NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Women with suspected breast cancer in low- and middle-income countries often face delayed diagnosis due to systemic barriers, leading to worse outcomes compared to developed countries. To fill this gap, we will determine whether a portable diagnostic kit for breast cancer that merges point-of-care technologies in both ultrasound imaging and molecular/cellular pathology can mitigate these barriers to timely diagnosis. The portable diagnostic kit will be deployed in clinical settings for women with breast cancer —first in U.S.-based settings, then in the intended population in Uganda— and evaluated against gold standard methods for the ability to visualize breast tumors and characterize their cellular/molecular pathology to guide treatment.

PI_NAMEs: NIYONZIMA, NIXON ;SCHEEL, JOHN R (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 3-Dimensional;Address;aged;anti-cancer research;Biological Markers;Breast;Breast Cancer Detection;Breast Cancer Patient;breast pathology;Businesses;cancer diagnosis;Cancer Diagnostics;care delivery;Caring;cellular pathology;Cellular Phone;Clinic;Clinical;Clinical effectiveness;clinical efficacy;clinically significant;Cluster randomized trial;Collaborations;community advisory board;compare effectiveness;Consultations;cost;Cost Analysis;cost effective;Cytology;Cytopathology;Death Rate;Decentralization;design verification;Detection;Developed Countries;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic Reagent Kits;diagnostic technologies;Diagnostic tests;Early Diagnosis;Education;Effectiveness;Engineering;ERBB2 gene;Estrogens;Evaluation;Face;Fatality rate;Feedback;Fine needle aspiration biopsy;geographic barrier;global health;Health;health care delivery;health empowerment;Health Personnel;Health Services Accessibility;Healthcare;Healthcare Systems;Hospitals;Image;Immunodiagnostics;improved;Infrastructure;innovation;Institution;Intervention;Lesion;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Ultrasonography;Mammography;Methods;Mission;Modernization;Molecular;molecular pathology;multidisciplinary;Neighborhood Health Center;novel;novel diagnostics;Oncologist;Outcome;Pathology;Patient-Focused Outcomes;Patients;Performance;point of care;Point of Care Technology;point-of-care diagnostics;Population;portability;Positioning Attribute;Preparation;primary care clinic;Process;Progesterone;Provider;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;receptor;Recommendation;Resource-limited setting;Resources;Rural;Sampling;Sensitivity and Specificity;Services;Stains;standard of care;Symptoms;System;systemic barrier;Target Populations;Technology;Testing;Time;Tissue Sample;Training;Travel;Tumor Markers;Uganda;Ultrasonography;ultrasound;urban area;usability;user-friendly;Validation;Visualization;Woman;women's diagnosis;Women's study

PROJECT_TITLE: Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-Q (M1)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Investigating predictors of smoking cessation and relapse in socioeconomically disadvantaged young adults (SDYA) who smoke is of critical public health importance due to the disproportionately higher rates of smoking and tobacco-related disease and illness among SDYA in the U.S. The goal of this MOSAIC K99/R00 application is to understand the impact of social-contextual stressors on psychopharmacological mechanisms of smoking cessation and relapse experienced in real-time among 100 SDYA who smoke and are willing to make a serious quit attempt in the next 30 days. Identifying event-level predictors that lead to smoking relapse in SDYA can inform the development of tailored smoking cessation interventions that address and ameliorate these barriers to cessation for SDYA, which may contribute to reducing tobacco-related health disparities in this high-risk group.

PI_NAMEs: BELLO, MARIEL SEANNE MERCADO (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adult;Affect;Age;Applications Grants;Area;Characteristics;Cigarette;cigarette smoke;community advisory board;community engaged research;Data;Data Analyses;Dependence;Development;Disease;Ecological momentary assessment;Environment;Etiology;Event;experience;Faculty;Financial Hardship;Future;Goals;health disparity;high risk population;informant;Intervention;Interview;Laboratories;Lead;Life;life span;Lived experience;marginalized population;Mentors;Methodology;Methods;Modeling;mortality;Motivation;National Institute of Drug Abuse;Nature;negative affect;Nicotine Withdrawal;Pattern;Persons;Phase;Pilot Projects;pilot test;prevent;programs;Protocols documentation;psychopharmacologic;Public Health;recruit;Reporting;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Risk;Sampling;skill acquisition;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;smoking relapse;Social Environment;social health determinants;socioeconomic disadvantage;Strategic Planning;stressor;Structure;Surveys;Testing;Time;Tobacco;Tobacco Dependence;Tobacco use;Training;Withdrawal;Withdrawal Symptom;Work;young adult

PROJECT_TITLE: The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Black individuals with chronic obstructive pulmonary disease (COPD) are at high cardiovascular (CVD) risk. We will engage stakeholders to design and pilot test the first intervention to reduce CVD risk and improve quality of life specifically among Black people with COPD. I will become an expert in implementation science, ready to test interventions to improve health equity in COPD outcomes.

PI_NAMEs: KRISHNAN, JAMUNA  (contact)

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Active Learning;Address;Adult;adverse outcome;American Heart Association;Attention;Award;Behavior;Behavior Therapy;black patient;Black Populations;Black race;Blood Glucose;Blood Pressure;Body Weight;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Caring;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinic;Clinic Visits;Clinical;Clinical Trials;Communication;Communities;comorbidity;Conduct Clinical Trials;Counseling;design;Diabetes Mellitus;Diet;Discrimination;Disease Outcome;Disparity;distrust;Dyspnea;Education;Effectiveness;effectiveness measure;effectiveness testing;Elements;Event;evidence base;Evidence based intervention;experience;Face;Feedback;Foundational Skills;Future;Goals;Guidelines;health disparity;health equity;Health system;Healthcare Systems;High Prevalence;Hospitalization;Hypertension;implementation framework;implementation science;improved;improved outcome;Individual;innovation;Intervention;K-Series Research Career Programs;Lead;Life;Life Style;Life Style Modification;Lipids;Lung;Measures;Medical;Mentors;Mentorship;Morbidity - disease rate;mortality;Motivation;novel;Outcome;Participant;patient-level barriers;Patients;persistent symptom;Physical activity;pilot test;Population;Prevalence;prevent;preventive intervention;prototype;Provider;Public Health;Qualitative Methods;Qualitative Research;Quality of life;Race;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Risk Factors;Risk Reduction;Scientist;skills;Sleep;Smoking;smoking cessation;social;Space Walks;Statistical Data Interpretation;Testing;therapy design;therapy development;Time;Training;uptake;user centered design

PROJECT_TITLE: COPDHeart: Improving Cardiovascular Health Among Black Adults with COPD

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (M3)]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Access to gender affirming medical care in adolescence is considered standard of care by all major national medical associations in the United States. Despite evidence of improved mental health outcomes and medical consensus that gender affirming care is medically necessary, many state level policies restrict or ban medical care for transgender youth. We propose to determine the feasibility of a longitudinal, mixed methods study that explores the psychosocial, mental health, and physical health outcomes of these policies for transgender and gender diverse youth in preparation for a future R01.

PI_NAMEs: HUTCHENS, KENDRA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Academy;Address;Adolescence;Adolescent;Adult;Advocacy;Age;Agreement;Alabama;American;American College of Obstetricians and Gynecologists;Association of American Medical Colleges;Caring;Characteristics;Childhood;Clinical;cognitive interview;Communities;community advisory board;Consensus;Data;Data Collection;data management;Databases;Discrimination;Enrollment;experience;Face;Feasibility Studies;Florida;Frequencies;Future;gender affirming care;gender affirming medical care;gender diverse;Gender Identity;Generations;geographic barrier;Geography;Goals;Gynecology;Health;health assessment;Health Personnel;Health Status;Healthcare Systems;improved;Individual;innovation;instrument;interest;Interview;Knowledge;Laws;Lawyers;Lead;Literature;Lived experience;Longitudinal Surveys;Measures;Medical;medically necessary care;Mental Depression;Mental Health;Methods;National Institute of Child Health and Human Development;Natural experiment;Oklahoma;Operative Surgical Procedures;Outcome;Outcome and Process Assessment;Outcome Assessment;Parents;Participant;participant enrollment;Patient Self-Report;Pediatrics;Pelvic Examination;Personal Satisfaction;physical conditioning;Play;Policies;Population;Preparation;Preventive healthcare;primary outcome;Procedures;prospective;Provider;psychosocial;Public Health;recruit;Reporting;Research;Role;Sample Size;Sampling;screening;Services;Sexual and Gender Minorities;Sexual Health;Sexually Transmitted Diseases;social media;Societies;standard of care;statistics;Statutes and Laws;Stigmatization;study population;suicidal;Surveys;Time;timeline;transgender;trend;United States;United States National Institutes of Health;willingness;Work;Youth

PROJECT_TITLE: Feasibility study for assessing processes and outcomes related to gender affirming care

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE There is a critical need to identify novel modifiable behavioral targets to improve treatment outcomes in obsessive-compulsive disorder (OCD), as only 40% of those treated with a first-line treatment remit, and 59% of those who remit subsequently relapse. Based on accumulating evidence implicating delayed circadian rhythms in OCD, the proposed project will test the efficacy of light therapy (including morning bright light and evening dim light) for OCD in adults with OCD+delayed bedtimes and examine photic sensitivity and habitual light exposure patterns in adults with OCD+delayed bedtimes compared to healthy controls. This project will provide me with training in the necessary clinical translational sleep and circadian medicine skills for a long- term research program in understanding the role of delayed circadian rhythms in OCD etiology and developing a novel, scalable treatment that can be easily incorporated into existing first-line treatments to improve treatment outcomes in OCD.

PI_NAMEs: COX, REBECCA C (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: active method;Adult;Aftercare;Age;anti-depressive agents;Area;Behavior Therapy;Behavioral;Brain region;circadian;Circadian Rhythms;clinical translation;Clinical Trials;comorbidity;comparative efficacy;compulsion;Cues;Data;Development;Disease;Disease remission;Distress;Ecological momentary assessment;economic cost;efficacy testing;Etiology;Exhibits;Exposure to;Functional impairment;Gilles de la Tourette syndrome;Glass;Height;Human;improved;Individual;Individual Differences;innovation;Intervention;K-Series Research Career Programs;Light;light effects;Link;Literature;Measurement;Measures;Medicine;Melatonin;Methods;Modality;Modeling;Monitor;novel;novel therapeutics;Obsession;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Participant;Patients;Pattern;Phase;phenomenological models;Photophobia;Phototherapy;pilot test;Placebos;Post-Traumatic Stress Disorders;power analysis;Prevalence;Prevention;primary outcome;programs;prospective;Psychopathology;Randomized;reduce symptoms;Relapse;repetitive behavior;Research;response;Role;Sample Size;Sampling;secondary outcome;Services;Severities;Single-Blind Study;skills;Sleep;symptomatic improvement;Symptoms;Testing;theories;Thinking;Time;Training;treatment duration;treatment group;Treatment outcome;wearable device;Work;Writing

PROJECT_TITLE: Light therapy for obsessive-compulsive disorder: A circadian medicine approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (03)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This career award develops Dr. Croff's expertise in three critical areas to develop her SHARP brain health program - reminiscence therapy, measures of cognition and social engagement, and dissemination and implementation science. Dr. Croff will lead the SHARP Learning Collaborative across three cites to understand and implement environmental and cultural adaptations to the SHARP approach, then subsequently test the approach with 36 older Black adults to develop feasibility and acceptability and finally, to assess fidelity across sites. Training and research experience culminates in the development of a comprehensive SHARP protocol and fidelity checklist for easier adoption and scalability.

PI_NAMEs: CROFF, RAINA L (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: acceptability and feasibility;Adoption;Adult;Aging;Alzheimer's Disease;Anxiety;Anxiety Disorders;Archives;Area;Award;Black American;Black race;brain health;career;Cities;Clinical Trials;Code;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Communities;community engagement;community organizations;Coupled;Data;depressive symptoms;design;Development;digital;dissemination science;efficacy testing;empowerment;environmental adaptation;Environmental Risk Factor;Evaluation;experience;Feedback;Focus Groups;Geography;geriatric depression;Goals;Health;Image;Imagery;Impaired cognition;implementation science;improved;Institution;interest;Intervention;intervention delivery;Learning;Life;Link;Location;Loneliness;Measures;meetings;member;Mental Depression;Mental Health;mental state;Mentors;Methods;mild cognitive impairment;mobile application;mood symptom;Moods;Neighborhoods;Oral;Oregon;Outcome;Participant;participant retention;patient engagement;Patient Self-Report;Personal Satisfaction;preference;Program Evaluation;programs;Protocols documentation;Recording of previous events;recruit;Research;retention rate;Route;Safety;satisfaction;service organization;Shapes;Site;Site Visit;social;social engagement;Standardization;Surveys;Testing;Time;Training;United States National Institutes of Health;Video Recording;Walking;Work

PROJECT_TITLE: The SHARP Study: Developing Acceptability, Feasibility, and Fidelity of a Reminiscence-based Cognitive Health Intervention Across Three Black American Communities

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Cerebrovascular;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because understanding the underlying physiological mechanisms of the non-invasive functional MRI signal is expected to advance how fMRI maps should be interpreted, which is essential for the proper understanding of human brain function. Thus, the proposed research is relevant to the NIH’s mission that seeks fundamental knowledge about the nature and behavior of humans. Such knowledge will enhance health and reduce illness and disability.

PI_NAMEs: FUKUDA, MITSUHIRO  (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Agreement;Animal Model;Animals;Area;awake;Behavior;Behavioral;blood oxygen level dependent;Brain;Calcium;Calcium Signaling;Cells;cerebral blood volume;Cerebrovascular Circulation;Cognition;Cognitive;cognitive task;contrast enhanced;Dependence;Detection;disability;Discrimination;discrimination task;Dissociation;Excision;excitatory neuron;experimental study;Exposure to;Fiber;Functional Magnetic Resonance Imaging;Goals;Health;hemodynamics;hippocampal pyramidal neuron;Human;Image;Imaging Device;innovation;Knowledge;Maps;Methods;Mission;Monkeys;Mus;Nature;neural;Neuromodulator;Neurons;neuroregulation;Neurosciences Research;neurovascular;neurovascular coupling;odor discrimination;Odors;olfactory bulb;Olfactory Pathways;optogenetics;Outcome;Output;Photometry;Physiological;piriform cortex;Play;Population;Public Health;Reporting;Research;Resources;response;Role;Sensory;sensory stimulus;Signal Transduction;Smell Perception;Stimulus;Training;United States National Institutes of Health;virtual;Visual;visual stimulus

PROJECT_TITLE: Neurovascular coupling during context-dependent sensory processing

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: ATLANTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Classically, the role that the homeostatic baroreflex plays in the development of cardiovascular disease has been questionable, due to the lack of tools that selectively target arterial baroreceptors. We have developed a novel approach to selectively target arterial baroreceptors that innervate the aortic arch. Our goal is to utilize this approach to revisit the role that the baroreflex plays in the development of hypertension.

PI_NAMEs: EL SAAFIEN, KHALID  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Ablation;Action Potentials;Afferent Neurons;Animal Model;Anti-Hypertensive Agents;aortic arch;Area;Atlases;Back;Baroreflex;Belief;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure regulation;Blood Vessels;Brain;Calcium;Cardiovascular Diseases;cardiovascular pharmacology;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;carotid sinus;Cause of Death;Chemoreceptors;Chronic;Development;Disease;Drug resistance;epithelial Na+ channel;Exhibits;experimental study;Failure;Fire - disasters;Functional disorder;Gene Combinations;Gene Expression;gene product;Gene Transfer;Genetic;Genetic Identity;Glean;Goals;Heart;hindbrain;Hypertension;Image;In Situ Hybridization;in vivo;in vivo calcium imaging;insight;Ion Channel;kidney vascular structure;Link;Low Cardiac Output;mechanotransduction;Mediating;Mentors;Mentorship;Messenger RNA;Methodology;Modeling;Molecular;molecular phenotype;Monitor;mortality;multi-photon;Mus;Nerve;neural;neuronal excitability;Neurons;Nociception;Nodose Ganglion;novel;novel strategies;Nucleotides;optogenetics;Outcome;Patients;Perfusion;Pharmaceutical Preparations;Phase;Piezo 1 ion channel;Play;Pressoreceptors;pressure;programs;receptor;Reflex action;Renovascular Hypertension;Research;Resistant Hypertension;Role;Scientist;Signal Transduction;Sodium;Stretching;Sympathetic Nervous System;Techniques;Testing;Therapeutic;Tissues;tool;Training;transcriptome sequencing;Vascular resistance;Viral;Visit

PROJECT_TITLE: Investigating Afferent Baroreflex Dysfunction in Hypertension


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative: Postpartum hemorrhage (PPH) is the leading global cause of maternal death, leading to more than 200 deaths per day. Uterine atony, weak and insufficient uterine contraction after delivery, causes about 80% of PPH. This project will provide important insights into how the uterus normally contracts after delivery and what goes wrong in cases of uterine atony, knowledge that may facilitate development of new treatments for uterine atony and PPH.

PI_NAMEs: ANSARI, JESSICA  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;Agonist;Animal Model;antagonist;Attenuated;Award;Basic Science;biobank;Biological Assay;Biology;Calcium;Calcium Signaling;career;Caring;Cations;Cell Culture Techniques;Cell membrane;Cell Nucleus;Cells;Cesarean section;Cessation of life;clinical care;Clinical Data;Clinical Research Protocols;cohort;Collagen;Contracts;Data;Development;differential expression;Discipline of obstetrics;experience;Fellowship Program;Freezing;Functional disorder;Future;Gel;Generations;Genes;Genetic Variation;Goals;Hemorrhage;Human;Image;In Vitro;in vivo;Infrastructure;innovation;insight;knock-down;Knowledge;Laboratory Research;Link;maternal morbidity;Maternal Mortality;Maternal-fetal medicine;Measures;Mediating;Medical;Membrane;Mentorship;Modernization;Molecular;Mus;Myography;Myometrial;new therapeutic target;novel;obstetric care;Obstetrical Anesthesia;overexpression;Oxytocin;Oxytocin Receptor;pharmacologic;Phosphorylation;Physicians;Physiological;Physiology;Placenta;Positioning Attribute;Postpartum Hemorrhage;pre-clinical;Pregnancy;Premature Labor;Prevalence;prevent;Prolonged Pregnancy;Prophylactic treatment;receptor;Research;response;Rodent Model;Role;Sampling;Science;Scientist;single nucleus RNA-sequencing;single-cell RNA sequencing;skills;Small Interfering RNA;Smooth Muscle;Smooth Muscle Myocytes;standard of care;targeted treatment;Testing;Tissue Sample;Tissues;Training;transcriptomics;Translating;translational medicine;Translational Research;treatment strategy;TRPV channel;uterine contractility;Uterine Contraction;Uterine Inertia;uterine smooth muscle cell;uterine smooth muscle contraction;Uterus;Vanilloid;Virginia

PROJECT_TITLE: Oxytocin-mediated calcium signaling in physiologic uterine contractility and uterine atony

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Pediatric brain MRI is essential to accurately diagnose, monitor, and treat pediatric brain tumors. However, the current practice carries risks, including a long-term detrimental risk to a child's cognitive development posed by repeated sedation and neurotoxic properties from gadolinium-based contrast agent (GBCA) injections. This proposal aims to develop a versatile motion-robust quantitative magnetic resonance imaging (qMRI) protocol, eliminate redundancies in MRI exams, generate full-dose post-contrast images from low-dose qMRI acquisition, evaluate the diagnostic equivalency and image quality of standardized contrast-weighted images generated from biophysical tissue parameter maps, and clinically deploy the developed technology for pediatric patients with brain tumors. The new qMRI protocol will reduce the scan time, mitigate the sensitivity to motion degradation, and allow us to establish the feasibility of mitigating long-term cognitive effects and gadolinium deposition in the brain and body by reducing the need for sedation and the amount of GBCAs, respectively.

PI_NAMEs: JAIMES COBOS, CAMILO ;JUN, YOHAN  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 10 year old;3-Dimensional;8 year old;accurate diagnosis;Acute;Address;Adoption;Adverse effects;Anesthetics;biophysical properties;Biophysics;Brain;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;cancer imaging;Child;Childhood;Childhood Brain Neoplasm;Clinical;clinical imaging;Cognitive;cognitive development;Computer software;contrast enhanced;contrast imaging;Contrast Media;cost;Data;Deposition;diagnosis standard;Diagnostic;Digital Imaging and Communications in Medicine;Disease;Dose;Ensure;Environment;Gadolinium;Goals;Guidelines;Healthcare Systems;Heavy Metals;high resolution imaging;Image;image reconstruction;Immobilization;Impaired cognition;improved;Injections;Institution;Lanthanoid Series Elements;Leptomeninges;Lesion;Life Expectancy;life span;Magnetic Resonance Imaging;Malignant Childhood Neoplasm;Maps;Measures;Metal exposure;Methods;Modeling;Monitor;Morphologic artifacts;Motion;motion sensitivity;neuro-oncology;Neuroanatomy;Neurocognitive;neurotoxic;Oncology;Parameter Estimation;Patients;Pediatric Neoplasm;Pediatric Oncology Group;pediatric patients;Physiologic pulse;Population;Preparation;Property;Protocols documentation;radiologist;Reading;Recommendation;Renal function;Reporting;Reproducibility;Research;Resolution;response;Risk;Running;Scanning;Sedation procedure;sedative;Speed;Staging;Standardization;System;Techniques;Technology;Testing;Therapeutic Equivalency;Time;Tissues;Translating;treatment response;United States;Vulnerable Populations;Wait Time

PROJECT_TITLE: Rapid, Motion-Robust, and Low-Gadolinium MRI for Pediatric Brain Tumors

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Prevention;Prostate Cancer;Rehabilitation;Urologic Diseases

ORG_DEPT: UROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Prostate cancer (PCa) is the most common non-cutaneous cancer in U.S. men and causes significant short- and long-term sexual side effects (i.e., sexual dysfunction) in up to 90% of patients. Although multiple evidence-based therapies for sexual dysfunction (e.g., psychotherapy, medications, surgery) exist, many PCa patients face significant barriers to communicating with their providers about sexual dysfunction, which impairs sexual recovery. We propose to rigorously adapt and pilot test an evidence-based sexual health communication skills training intervention for PCa patients to improve patient-provider communication about sexual health in PCa care and, thereby, facilitate improved sexual recovery and sexual health outcomes among PCa patients.

PI_NAMEs: GUPTA, NATASHA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Age;Behavior Therapy;Biopsy;Breast Cancer Patient;cancer care;Cancer Control;cancer diagnosis;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer type;Clinical;Clinical Trials;Communication;community advisory board;community engagement;Counseling;Data;Deformity;design;Development;Diagnostic;dissemination science;Distress;Educational Intervention;efficacious intervention;efficacy trial;Elements;Erectile dysfunction;evidence base;Face;Feedback;Female;Focus Groups;Functional disorder;Future;Gender;Goals;health communication;help-seeking behavior;Impairment;implementation outcomes;implementation science;improved;Individual;insight;Intervention;intervention refinement;Intervention Trial;Interview;lens;Libido;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Media Intervention;men;Menopause;Mental Health;Multimedia;Narration;novel;Operative Surgical Procedures;Outcome;Patient Representative;patient-clinician communication;patient-level barriers;Patients;penis;Pharmaceutical Preparations;pilot test;Prevalence;Prostate Cancer therapy;prototype;Provider;provider communication;Psychotherapy;Quality of life;Questionnaires;Randomized, Controlled Trials;Recovery;Research;Research Personnel;resource guides;satisfaction;Self Direction;Self Efficacy;Sex Behavior;Sexual Dysfunction;Sexual Health;side effect;skills training;Structure;Survivors;Symptoms;Taxonomy;Testing;tool;Treatment Side Effects;Urologic Cancer;usability

PROJECT_TITLE: Adaptation and Testing of an Evidence-Based Sexual Health Communication Skills Training Intervention for Patients with Prostate Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Body positivity, the promotion and acceptance of diverse body sizes and appearances, is one approach to mitigating weight stigma, which is associated with depression, anxiety, disordered eating, reduced physical activity, and weight gain. Latinx adolescents have higher rates obesity than their white counterparts and are at risk of experiencing multiple forms of stigmatization. This study will assess the impact of a social media campaign that promotes body positivity on weight stigma and mental health among Latinx youth, compared to a control campaign.

PI_NAMEs: ALBERT, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Adult women;Adverse effects;Anxiety;Appearance;Attention;Attitude;Baseline Surveys;Behavior;Body Image;Body Size;Body Weight;Body Weight decreased;career;Childhood;Collaborations;community engaged research;coping;design;Development;Eating Disorders;Educational process of instructing;Effectiveness;evidence base;experience;experimental study;Exposure to;Feedback;Feeling;follow-up;Future;Gender;Goals;Grant;Health;health communication;Hour;Image;improved;Individual;Instagram;Institution;Intervention;Interview;Latinx;Latinx population;longitudinal analysis;marginalization;marginalized population;Marketing;Media Campaign;Media Intervention;media use;Mental Depression;Mental Health;Mentored Research Scientist Development Award;Mentors;Mentorship;Obesity;Outcome;Overweight;Participant;peer;Persons;Physical activity;physical conditioning;pilot test;poor health outcome;programs;Qualitative Methods;Race;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Risk;Sampling;satisfaction;secondary outcome;self esteem;Sex Orientation;Shapes;Social Development;Social isolation;social media;social norm;Social Responsibility;social stigma;Stigmatization;substance use;Surveys;Symptoms;Teenagers;Testing;therapy design;Time;Training;Weight;Weight Gain;Youth

PROJECT_TITLE: Leveraging social media to promote body positivity among Latinx adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (M2)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Infectious Diseases;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Mutation of the ATP2C1 gene has been linked to Hailey-Hailey disease, an incurable dermatologic condition that causes recurrent, painful skin blisters but lacks any approved therapies. This disorder primarily affects keratinocytes, disrupting adhesion between these cells within the epidermis, which compromises skin tissue integrity and permits cutaneous infections. In this project, we leveraged gene editing to generate human keratinocytes having the ATP2C1 gene deleted to establish a laboratory model of Hailey-Hailey disease that we will use to identify new treatment strategies for this rare disorder.

PI_NAMEs: SIMPSON, CORY L (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Ablation;Abnormal Cell;Acantholysis;Actins;Adhesions;Adhesives;Affect;Antioxidants;Automobile Driving;Autophagocytosis;autosome;Biological;biological adaptation to stress;Biological Assay;Biopsy;Biosensor;Bulla;Ca(2+)-Transporting ATPase;Cadherins;Cell model;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Cellular Morphology;chronic pain;Clinical Trials;cohesion;Color;Confocal Microscopy;Coupling;CRISPR/Cas technology;Cutaneous;Cytoskeletal Proteins;Cytoskeleton;Data;Dermatologic;Desmosomes;Disease;disease model;Dissociation;drug candidate;drug development;Drug Targeting;Drug usage;druggable target;Environment;Epidermis;Epithelium;Exhibits;Familial benign pemphigus;FDA approved;fluorophore;Functional disorder;Future;gain of function;Gene Deletion;Gene Mutation;Genes;Genetic;Genetic Diseases;Goals;Golgi Apparatus;Guanosine Triphosphate Phosphohydrolases;Hereditary Disease;Heterozygote;Human;Hypersensitivity;Image;imaging modality;Impairment;improved;Infectious Skin Diseases;Inflammatory;Intercellular Junctions;keratinocyte;Knockout Mice;Laboratories;Lead;Link;live cell imaging;loss of function;Maps;Mechanics;mechanotransduction;Metabolism;Methods;Microscopy;Microtubules;misfolded protein;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mus;Mutation;novel;novel therapeutic intervention;Other Genetics;Oxidative Stress;Pain;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pemphigus;Persons;Pharmaceutical Preparations;pharmacologic;Process;Proteins;proteotoxicity;Quality of life;Rare Diseases;rational design;Reactive Oxygen Species;Recurrence;recurrent infection;Regulation;repaired;response;rho GTP-Binding Proteins;Role;Route;Shapes;Signal Transduction;Skin;skin disorder;Skin Tissue;Stress;superinfection;System;Testing;Therapeutic;Three-Dimensional Imaging;Tissue imaging;Tissue Model;Tissues;trafficking;transcriptome sequencing;Up-Regulation;Visualization;Work;wound

PROJECT_TITLE: Delineating pathogenic effects of ATP2C1 loss-of-function in human keratinocytes and organotypic epidermis to identify therapeutic strategies for Hailey-Hailey disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-8 (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE It remains unclear whether controlling blood glucose levels among individuals with gestational diabetes can mitigate the risk of obesity in their children and how the neighborhood environment may contribute to this relation. The proposed research applies a unique multilevel lens to understand the interrelationships between neighborhood- and individual-level factors and blood glucose levels during pregnancy and their role in childhood obesity development. This project will better inform clinical and public health recommendations and interventions with an ultimate goal to improve the health of pregnant individuals and their children.

PI_NAMEs: CHEHAB, RANA F. (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Affect;American;Behavioral;Biological;Black race;Blood Glucose;Blood Pressure;Body Composition;built environment;cardiometabolism;career;Child;Child Health;Childhood;Clinical;clinical development;clinical practice;cohort;Cohort Studies;Collaborations;Data;deprivation;diabetes management;Diabetes Mellitus;Diagnosis;Diet;disparity reduction;Environment;Epidemic;Epidemiology;Equity;ethnic disparity;Ethnic Origin;follow-up;food environment;Functional disorder;Future;Gestational Diabetes;glycemic control;Goals;Grant;Growth;Health;health disparity;Health Policy;High Prevalence;high risk;Hispanic;improved;in utero;indexing;Individual;Insulin Resistance;intergenerational;Intervention;Joints;Knowledge;lens;Life;Life Cycle Stages;Life Style;longitudinal analysis;Longitudinal Studies;Maternal and Child Health;Mediating;Mediation;Mentors;Mentorship;Modification;multi-component intervention;multi-racial;multidisciplinary;neighborhood association;Neighborhoods;nutrition;Obesity;obesity development;Obesity Epidemic;obesity in children;obesity risk;offspring;Outcome;Outcome Study;Pattern;Perinatal;perinatal complications;perinatal outcomes;Phase;Physical activity;population based;postnatal;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnant;prenatal;programs;Public Health;Race;racial disparity;Recommendation;Reduce health disparities;Research;Research Personnel;residential segregation;Risk;Risk Factors;risk mitigation;Role;skills;sociodemographics;Training;United States National Institutes of Health;walkability;Work

PROJECT_TITLE: Elucidating Neighborhood- and Individual-Level Factors Associated with Pregnancy Glycemia Levels and Childhood Obesity

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Depression;Genetics;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Serious Mental Illness;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHIATRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Co-morbid Major Depressive Disorder (MDD) increases risk for Alcohol Use Disorder (AUD) and unique genetic factors may contribute to AUD risk depending on MDD status. Furthermore, men and women display disparate patterns of temporal development of AUD with co-morbid MDD and their genetic liabilities for the disorders may be different. This project therefore proposes a plan of research considering innovative models to analyze sex-specific genetic and environmental effects on AUD at the item level to contribute to filling the current gap in scientific understanding of the mechanisms by which MDD and sex effects interact with common variants genetic signal to predispose to AUD.

PI_NAMEs: GENTRY, AMANDA ELSWICK (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Address;Age;alcohol comorbidity;Alcohol consumption;alcohol epidemiology;alcohol research;alcohol risk;alcohol use disorder;Alcohols;analytical method;biobank;Bioinformatics;Biological;biological sex;Biostatistical Methods;Cessation of life;Clinical;clinical predictors;clinically relevant;cohort;Collection;comorbidity;Complex;Complex Genetic Trait;Data;Data Collection;data resource;Data Set;Dedications;demographics;design;Development;Diagnostic;Dimensions;disability-adjusted life years;Disease;disease classification;disorder risk;Disparate;diverse data;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Etiology;Future;Genetic;genetic analysis;genetic architecture;genetic epidemiology;Genetic Predisposition to Disease;genetic variant;genome wide association study;Goals;Hereditary Disease;Heritability;Heterogeneity;improved;Individual;innovation;insight;instrument;Interdisciplinary Study;Investigation;K-Series Research Career Programs;Machine Learning;machine learning method;Major Depressive Disorder;Measures;Medicine;men;Mentors;Mentorship;method development;Methods;Modeling;Molecular Genetics;National Institute on Alcohol Abuse and Alcoholism;novel;Outcome;Pattern;Phenotype;Prevalence;programs;Property;Psychometrics;Research;Research Activity;Research Personnel;Research Support;Risk;Risk Factors;Sampling;Science;sex;Signal Transduction;socioeconomics;statistical and machine learning;Statistical Methods;Statistical Models;Strategic Planning;Structure;Substance Use Disorder;supervised learning;Surveys;Symptoms;Techniques;Time;Training;Training Activity;translational applications;Twin Multiple Birth;United States National Institutes of Health;Validation;Woman;Work

PROJECT_TITLE: Characterizing the sex-specific genetic architecture of alcohol use disorders with comorbid major depressive disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2 (AA)]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Immune-based therapies have transformed the treatment of many hematologic malignancies, but such approaches have had limited success for acute myeloid leukemia (AML), an aggressive hematologic malignancy that remains fatal in nearly half of diagnosed cases. However, there is great potential for T cell- based immunotherapeutic approaches for treating AML given (1) studies demonstrating impaired T cell immunity in AML patients, (2) clinical data illustrating correlation between the bone marrow immune landscape and treatment responses to both chemotherapy and immunotherapy, and (3) the curative potential of allogeneic hematopoietic cell transplantation for AML arising from the immune-mediated graft-versus-leukemia activity of donor T cells. The goal of this study is to perform deep analysis of T cells in parallel with surrounding populations in the bone marrow, the site where AML emerges, to elucidate key mechanisms driving T cell functional responses to AML longitudinally, and to identify immunologic targets for potential therapeutic intervention.

PI_NAMEs: DEWOLF, SUSAN E (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Advisory Committees;Affect;Allogenic;Anatomy;Antibodies;antileukemic activity;Autologous;Automobile Driving;Award;Bioinformatics;Biological Assay;Biology;Bone Marrow;cancer cell;candidate identification;career;career development;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Physiology;Cells;Cellular biology;Cellular Immunity;Cellular immunotherapy;chemotherapy;Clinical;Clinical Data;Clinical Investigator;Clone Cells;Color;Counseling;cytotoxic;Data;Dedications;Development Plans;Diagnosis;Disease;Disease remission;Doctor of Philosophy;dynamical evolution;effective therapy;Evolution;exhaustion;experience;Flow Cytometry;Future;Genes;Genetic Transcription;Genomics;Goals;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Heterogeneity;Human;Immune;Immune Targeting;Immunity;Immunologic Techniques;Immunologics;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;Impairment;in silico;In Vitro;International;Investigation;Knowledge;Laboratories;Learning;leukemia;leukemia treatment;Longitudinal cohort;Malignant - descriptor;Mediating;Mentors;Mentorship;Molecular;mouse model;Myeloproliferative disease;Nature;Non-Malignant;novel therapeutics;Pathology;Pathway interactions;Patients;peripheral blood;Pharmacology;Phenotype;Physicians;Population;Positioning Attribute;prevent;Program Development;programs;Property;Proteomics;Records;Regulatory T-Lymphocyte;Research;Research Personnel;response;Sampling;Scientist;senescence;Shapes;Site;skills;success;T cell anergy;T cell receptor repertoire sequencing;T memory cell;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Techniques;Testing;Therapeutic Intervention;Training;translational medicine;Translational Research;Treatment Efficacy;treatment response;treatment strategy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;United States

PROJECT_TITLE: Understanding mechanisms of impaired immunity in the AML bone marrow


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hematology;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Sickle Cell Disease;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative Recent meta-analyses have shown that women with sickle cell disease (SCD) are at 26x greater risk for maternal mortality than their healthy counterparts; a figure which, despite the adoption of improved care plans, has shown little to no significant improvement over the last two decades. It is our belief that hemolysis-induced overstimulation of the complement system is at the forefront of the placental insufficiency and poor pregnancy outcomes seen in SCD. We now aim to investigate this hypothesis using a well-established pre-clinical mouse model of SCD and various therapeutic interventions to improve outcomes.

PI_NAMEs: CHAMBLISS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: absorption;Adoption;Anemia;Area;Belief;biobank;Biological Markers;Blood flow;Blood specimen;Blood Vessels;Breeding;career;Caring;Cell Count;Cesarean section;Cessation of life;Characteristics;Chronic;Circulation;Complement;Complement Activation;complement system;Conceptions;Death Rate;Decidual Cell;Deep Vein Thrombosis;Dependovirus;early pregnancy loss;Embryo;Enzyme-Linked Immunosorbent Assay;Erythrocytes;experience;experimental study;fetal;Fetal Growth Retardation;Fetal Weight;Functional disorder;Future;Genetic Transcription;Goals;Haptoglobins;Health;Hematocrit procedure;Hematology;Heme;heme oxygenase-1;Hemoglobin;Hemolysis;Hemolysis Induction;Hemopexin;high risk;Histology;Homeostasis;Hypertension;Immune;Immunohistochemistry;Immunology procedure;Impairment;improved;improved outcome;Inflammation;Inflammatory;Inflammatory Response;innate immune pathways;Investigation;Knock-out;Length;Leukocytes;Lipid Peroxidation;Litter Size;Maintenance;Maternal Mortality;maternal risk;Measures;Meta-Analysis;mouse model;Mus;Nitric Oxide;Outcome;overexpression;Oxidative Stress;Pathology;Phase;Phenotype;Physiologic pulse;Physiological;Placenta;Placental Insufficiency;pre-clinical;pre-clinical assessment;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;Premature Birth;Process;recruit;Research;Risk;Role;Sampling;Scheme;Serum;Sickle Cell;Sickle Cell Anemia;Signal Pathway;specific biomarkers;Structure of umbilical artery;System;systemic inflammatory response;Therapeutic;Therapeutic Intervention;Tissues;trophoblast;ultrasound;Uterus;Vascular Diseases;Vascular Endothelium;White Blood Cell Count procedure;Woman

PROJECT_TITLE: Investigating the Role of Heme-Induced Complement Activation in SCD Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M2)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Less than 50% of adolescents with mental illness receive care after accounting for insurance/economic factors and data also suggests stigma is a significant additional barrier to care; challenges to care are particularly severe for race/ethnic minority and lower socioeconomic youth. As untreated mental illness has long-term negative consequences on health and well-being, a public health approach using efficacious education-based anti-stigma programs in school settings is a priority to address stigma head-on and promote help-seeking among youth; yet these proven interventions are rarely integrated in typical school mental health programs. To promote mental health help-seeking and reduce mental health disparities among youth, this project will identify real-world implementation targets and strategies for school principals and health educators to increase the use of proven anti-stigma programs.

PI_NAMEs: DUPONT, MELISSA JULIANA (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Accounting;Address;Adolescent;Adopted;Adoption;Age;archived data;Attitude;barrier to care;Behavior;behavior influence;career;Caring;Clinical;community academic partnership;Community Participation;Competence;COVID-19 pandemic;Data;Data Collection;Data Set;Decision Making;Depressed mood;design;Development;digital;digital technology;Discipline;Disparity;Economic Factors;Education;Educational Curriculum;effective therapy;efficacious intervention;efficacy trial;Employment;empowerment;ethnic minority;Ethnic Origin;Evaluation;Experimental Designs;Feeling hopeless;follow-up;Fostering;Foundations;Future;Gender;Glean;Goals;Grant;Head;Health;health disparity;Health education;Health Educators;health service use;help-seeking behavior;Hour;Hybrids;implementation barriers;implementation facilitators;implementation research;implementation science;implementation trial;improved;Individual;Information Dissemination;innovation;Insurance;interest;Intervention;Interview;Knowledge;Leadership;Link;Literature;Measures;Mediator;medically underserved;Mental Depression;Mental disorders;Mental Health;mental health education;Mental health promotion;Mental Health Services;Mentored Research Scientist Development Award;Methods;New York;optimism;Outcome;peer violence;Personal Satisfaction;Population;post intervention;Presbyterian Church;Prevention;programs;Public Health;public health priorities;Quasi-experiment;Race;racial minority;Randomized;Readiness;Reporting;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Review Literature;school based health center;school health;Schools;Scientist;Severities;skills;social culture;social inclusion;social stigma;socioeconomics;Symptoms;System;teacher;Testing;theories;Training;Voice;Work;Writing;Youth

PROJECT_TITLE: Implementation of mental illness anti-stigma research evidence in the school system to promote help-seeking using a pilot hybrid type III trial with adaptive randomization and digital dissemination

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_DEPT: GENETICS

PHR: Project Narrative Polycystic kidney disease, in which the kidney accumulates fluid-filled sacs, is the leading genetic cause of renal failure, yet the primary driver of this disease remains unknown. We used a unique mouse model as an entry point to dissect disease-driving mechanisms uncovering a protein, ARL13B, as a main driver of renal cysts. Expanding upon this foundational knowledge, we propose to further examine ARL13B interacting proteins and unravel the pathways leading to kidney cysts.

PI_NAMEs: VAN SCIVER, ROBERT E (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: ADP-Ribosylation Factors;Affect;American;Amino Acids;ARL3 gene;Automobile Driving;Biochemical;Biochemistry;CDC2 gene;Cilia;Coupled;Critical Pathways;Cyst;Cystic kidney;Data;Development;Disease;Engineering;Exclusion;experimental study;Faculty;Family;flexibility;Future;Genes;Genetic;genetic approach;Goals;Guanosine Triphosphate Phosphohydrolases;in vivo;Institution;Investigation;Kidney;Kidney Failure;Knowledge;lectures;Link;Liquid substance;Localized Disease;loss of function mutation;Mediating;member;Mentors;Mentorship;Microtubules;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;novel;Organelles;Outcome;Pathogenesis;Pathway interactions;Phenotype;Phosphoric Monoester Hydrolases;Physiology;Polycystic Kidney Diseases;Probability;programs;Property;Proprotein Convertase 1;Protein Analysis;protein complex;Protein Family;Proteins;Publishing;Reagent;Regulation;Research;research and development;Research Personnel;Research Training;Resolution;Role;success;SWI1;tenure track;Testing;Therapeutic;Tissues;Training

PROJECT_TITLE: Unraveling the Ciliary Driver of Polycystic Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Necrotizing enterocolitis (NEC) is a severe and often fatal intestinal disease of prematurity that culminates in irreversible intestinal epithelial cell injury. Effective treatments for this devastating disease are lacking due to an inadequate understanding of protective and pathogenic signaling pathways in the neonatal intestine. This K08 career development proposal investigates the mechanisms involved in attenuating intestinal epithelial cell injury in NEC, which is critical for designing new effective treatment strategies for this devastating disease.

PI_NAMEs: FRAZER, LAUREN CAROLE (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acceleration;Achievement;Adult;Affect;Agonist;Anti-Inflammatory Agents;Antioxidants;Aryl Hydrocarbon Receptor;Attenuated;attenuation;Bacteria;Biology;Body System;career development;cell injury;Cellular biology;Cessation of life;cytokine;Data;Death Rate;Dedications;design;Development;Development Plans;dietary;Disease;Down-Regulation;dysbiosis;effective therapy;Ensure;Epithelial Cells;epithelial injury;Excision;Failure;Fumarates;Functional disorder;Funding;Gastrointestinal Diseases;Gene Modified;Gnotobiotic;Goals;gut inflammation;gut microbes;Health;improved;Indole-3-Carbinol;Infant;Inflammation;Inflammatory;Injury;innovation;International;Intestinal Diseases;intestinal epithelium;intestinal injury;Intestines;Investigation;Knowledge;Laboratories;Laboratory Finding;Ligands;Literature;Mediating;Mentors;Mentorship;microbial;microbiome;Microfluidic Microchips;Microfluidics;Modeling;mouse model;Mouse Strains;murine colitis;Mus;Necrosis;Necrotizing Enterocolitis;Neonatal;neonatal human;neonatal mice;neonatal patient;neonate;new therapeutic target;novel therapeutics;nuclear factor-erythroid 2;Operative Surgical Procedures;Organ failure;Outcome;Oxidative Stress;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;postnatal;Pre-Clinical Model;premature;prenatal;preterm newborn;Production;Proteins;Publishing;Receptor Signaling;Regulation;Research;Research Personnel;Risk;Role;Scientist;Severities;Signal Pathway;Signal Transduction;success;Testing;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;Tight Junctions;Training;transcription factor;Transcriptional Activation;treatment strategy;United States;Up-Regulation

PROJECT_TITLE: Regulation of signaling pathways mediating epithelial cell injury in the neonatal intestine

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

PHR: PROJECT NARRATIVE Double strand breaks (DSBs) are a type of DNA damage that is relevant to congenital diseases such as Ataxia telangiectasia, Li Fraumeni syndrome, and Bloom syndrome, as well as cancer and infertility. Incorrect repair of DSBs result in a type of mutation called structural variants (SVs). I will study the impact of mutations in DSB repair genes on the types of SVs in human genomes, which will result in better understanding of mechanisms of DSB repair, and how defects in this repair shape the genome and affect human disease.

PI_NAMEs: DALIN, SIMONA  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Affect;Algorithms;Area;Ataxia Telangiectasia;base;Biological Models;Bloom Syndrome;career development;Cells;Cellular biology;Communication;Computing Methodologies;Data;Data Set;Databases;Defect;Development Plans;Disease;DNA Damage;Double Effect;Double Strand Break Repair;Drug Targeting;Dryness;Environment;Exhibits;Frequencies;gene repair;Genome;genome integrity;genomic signature;genomic tools;Genomics;Germ Lines;Health;Heart Diseases;High Prevalence;homologous recombination;Human;Human Cell Line;human disease;Human Genome;Individual;Infertility;Inherited;innovation;Institution;Length;Li-Fraumeni Syndrome;Light;loss of function mutation;Lung Diseases;Maintenance;Malignant Neoplasms;Measures;Mediating;Meiosis;Mentors;Methods;Mitosis;Mitotic;Mutate;Mutation;Neurodegenerative Disorders;Outcome;Pattern;Phase;Play;Prevalence;Process;repair function;repaired;Research;response;Role;Scientist;Sequence Homologs;Sequence Homology;Shapes;Site;software development;Structure;Technology;Testing;The Cancer Genome Atlas;tool;Training;tumor;Underrepresented Populations;Variant;Work;Writing;Yeasts

PROJECT_TITLE: Factors Shaping the Genomic Spectrum of Structural Variants

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The proposed research is relevant to public health because developing new quantitative methods to target and guide epilepsy surgery will improve patient outcomes and reduce surgery side effects and costs. This research also brings together 15 major epilepsy centers to develop methods to standardize epilepsy treatment.

PI_NAMEs: SINHA, NISHANT  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Ablation;Anatomy;Area;Atlases;Biometry;Biostatistical Methods;Brain;brain abnormalities;Characteristics;Classification;Clinical;Clinical Data;clinical practice;clinical translation;cloud based;Cloud Computing;Collaborations;cost;Data;Data Collection;data platform;Data Set;data sharing;Devices;Diffusion Magnetic Resonance Imaging;Electroencephalography;Engineering;Epilepsy;Evaluation;Excision;experience;Extratemporal Epilepsy;Goals;Hand;Image;implantable device;improved;improved outcome;individual patient;Informatics;Infrastructure;innovation;Institution;Intervention;Lasers;Lesion;Magnetic Resonance Imaging;Manuals;Maps;Measures;Medical;Metadata;Methods;Modality;Modeling;Multi-Institutional Clinical Trial;multimodal data;multimodality;network models;neuroimaging;Neurology;neurosurgery;novel;Operative Surgical Procedures;Outcome;outcome prediction;Patient Care;Patient-Focused Outcomes;Patients;Persons;Phase;Population;programs;prospective;Public Health;Records;Research;Running;Sampling;Seizures;side effect;skills;Standardization;Structural defect;structural imaging;surgery outcome;Techniques;Temporal Lobe Epilepsy;Testing;Time;Tonic-Clonic Epilepsy;tool;Training;Translating;translational barrier;treatment optimization;United States;Validation;Work

PROJECT_TITLE: Scalable methods to quantify epileptic network and guide epilepsy surgery

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol-related alterations to the microbiota are vastly under studied during adolescence yet may influence normative neural trajectories through the microbiome-brain axis leading to increased risk of alcohol use disorder. The proposed project responds to the need for a multi-modal, comprehensive understanding of the physiological effects of alcohol during adolescence by expanding research into the periphery (i.e., oral microbiome) and investing the connection between the oral microbiome and the brain (i.e., microbiome-brain axis). Findings from this study will help generate a more thorough understanding of the biological consequences of adolescent alcohol use, with the long-term goal of informing novel prevention and intervention efforts that target the microbiota.

PI_NAMEs: KIRKLAND, ANNA E (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent alcohol effect;Adult;Age;Alcohol consumption;alcohol effect;alcohol measurement;alcohol risk;alcohol sensitivity;alcohol use disorder;Alcohols;Anterior;Area;Biological;Brain;brain research;career;career development;Categories;Central Nervous System;cingulate cortex;Communication;Data Collection;Development;Diagnosis;Dorsal;Dose;experience;Fostering;Future;gamma-Aminobutyric Acid;Glutamates;Goals;Grant;gut microbiome;gut microbiota;Heavy Drinking;insight;interest;Intervention;Investments;Knowledge;Lactobacillus;Life;Literature;Magnetic Resonance Spectroscopy;Maintenance;Measures;Mentors;Mentorship;Methods;Microbe;microbial composition;microbiome;microbiota;multimodality;N-acetylaspartate;National Institute on Alcohol Abuse and Alcoholism;neural;Neurons;Neurotransmitters;novel;Oral;oral microbial community;oral microbiome;Phase;Physiological;Play;Pre-Clinical Model;prebiotics;Predisposition;Prevention;Probiotics;Protons;recruit;Research;Research Personnel;Research Project Summaries;responsible research conduct;saliva sample;Science;Shotgun Sequencing;skills;System;Time;Training;underage drinking;United States National Institutes of Health;Upper digestive tract structure;Writing;Youth

PROJECT_TITLE: The effects of adolescent alcohol use on oral microbiota and the brain

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Primary Health Care;Social Determinants of Health

ORG_CITY: DAVIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Persons with end stage kidney disease (ESKD) depend on reliable transportation to dialysis sessions. This Mentored Patient-Oriented Career Development Award will provide foundational data on the social risks faced by patients with ESKD treated with dialysis and how to best measure the transportation insecurity they face. It will lay the groundwork for future studies on screening and interventions to address health related social risks in the ESKD population with the goal of improving health and advancing equity.

PI_NAMEs: RAZON, NA'AMAH  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: access disparities;Accountability;Address;adverse outcome;Affect;Appointment;Area;Award;career;Caring;Catheters;Clinical;cohort;Color;Communities;community advisory board;Community Health;cost;Data;design;Dialysis procedure;Disease Outcome;disparity reduction;Doctor of Philosophy;Emergency department visit;End stage renal failure;Epidemiology;Equity;experience;Exposure to;Face;Failure;Family Physicians;Foundations;Future;future implementation;Goals;Health;health care availability;Health Care Sector;health care service;health equity;health inequalities;Health Policy;Health Services Research;Health system;Healthcare;Hemodialysis;Home;Hospitalization;Improve Access;improved;Incidence;indexing;Individual;innovation;instrument;Intervention;Interview;K-Series Research Career Programs;Kidney Diseases;Learning;Low income;Measures;Medical;Mentors;Mentorship;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Newly Diagnosed;novel;novel strategies;Outcome;patient oriented;Patients;Performance;Persons;Policy Analysis;Policy Developments;Policy Maker;Population;Premature Mortality;Prevalence;Primary Care Physician;Process;Prospective, cohort study;racial disparity;Reporting;Research;Research Personnel;Risk;Rural;screening;Screening procedure;Security;Services;skills;social;Social Environment;socioeconomic disparity;Structure;system-level barriers;Testing;therapy development;tool;Training;Transportation;Travel;United States;United States Centers for Medicare and Medicaid Services;uptake

PROJECT_TITLE: MOBILIZE: Mobility & Transportation Solutions to Improve Hemodialysis Access


ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Patients diagnosed with metastatic breast cancer have limited treatment options, are more prone to develop resistance and are associated with high mortality. Using state of the art spatial technologies we will profile the genes and proteins of responders and non-responders following chemotherapy with macrophage targeting therapy and newly approved T cell activating agents. In order to identify new vulnerabilities that may overcome resistance.

PI_NAMEs: PEDROZA, DIEGO A (contact)

PROJECT_TERMS: Adjuvant Chemotherapy;Affinity;African American Women;anti-PD-1;Antibodies;Antigen Presentation;Architecture;B-Lymphocytes;Bioinformatics;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;Bromodeoxyuridine;cancer cell;CD8-Positive T-Lymphocytes;Cells;chemotherapy;Clinic;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;Combined Modality Therapy;Complex;Coupled;CSF1R gene;Cyclophosphamide;Cytometry;Diagnosis;Disease;Epithelium;Evolution;exhaustion;experimental study;Flow Cytometry;Freezing;Gene Expression;gene function;Genes;genetic manipulation;genetic signature;Genetically Engineered Mouse;high dimensionality;Human;Image;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunocompetent;immunosuppressive macrophages;In complete remission;in silico;In Vitro;in vivo;Infiltration;Inflammatory;Injections;Interferons;Interleukin-15;Liver;Liver neoplasms;Lung;Lung Neoplasms;Macrophage;Malignant Neoplasms;Mesenchymal;Metastatic breast cancer;Metastatic Neoplasm to the Liver;Metastatic Neoplasm to the Lung;Methods;Modeling;Monoclonal Antibodies;mortality;MS4A1 gene;Mus;Mutate;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Outcome;Pathologic;Pathway interactions;Patients;Phenocopy;Phenotype;Play;Population;Portal vein structure;pre-clinical;Pre-Clinical Model;pressure;Primary Neoplasm;Process;Prognosis;programmed cell death ligand 1;protein profiling;Proteins;Proteomics;Randomized;RANTES;recruit;Recurrence;Resistance;Resistance development;resistance mechanism;responders and non-responders;response;RNA Interference;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;small hairpin RNA;Small Interfering RNA;small molecule inhibitor;standard of care;synergism;System;T cell infiltration;T-Cell Activation;T-Lymphocyte;Tail;targeted treatment;Techniques;Technology;Therapeutic;therapy resistant;Tissues;TP53 gene;transcriptome;transcriptomics;treatment duration;Treatment Failure;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;Tumor Immunity;Tumor Promotion;Tumor Suppressor Genes;Tumor-associated macrophages;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Veins;Vimentin;Western Blotting;Withholding Treatment;young woman

PROJECT_TITLE: Characterization of the metastatic TIME by subcellular spatial profiling


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Computer-aided detection (CAD), which uses artificial intelligence to analyze chest X-rays, is now WHO- recommended for tuberculosis (TB) screening and holds the potential to improve TB detection in high-burden, low-resource communities. This proposed research seeks to evaluate the adaptive application of CAD for community-based TB screening in sub-Saharan Africa, utilizing individualized and context-specific methods, as an alternative to the current standard of a "one-size-fits-all" approach. By assessing diagnostic accuracy, implementation barriers, and cost-effectiveness of each screening strategy, the insights gained from this study could be used to facilitate earlier detection of TB and reduce the high morbidity and mortality caused by tuberculosis.

PI_NAMEs: SUNG, JOOWHAN  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;Age;Algorithms;Artificial Intelligence;artificial intelligence model;Attention;Award;career;career development;Caring;case finding;Characteristics;Chest;Client;Clinical Investigator;Communities;community-centered;comparative;comparative effectiveness;Complex;computer aided detection;Computer software;convolutional neural network;cost;cost effective;cost effectiveness;Country;Data;Data Collection;Data Set;deep learning;deep learning model;design;Detection;detection platform;Diagnosis;diagnostic accuracy;Diagnostic tests;Digital X-Ray;Early Diagnosis;economic implication;Epidemiology;experience;falls;Foundations;Funding;future implementation;Goals;Health;health economics;high risk population;HIV;implementation barriers;implementation evaluation;implementation process;implementation science;implementation/effectiveness;improved;Individual;Individual Adjustment;Infrastructure;innovation;insight;Intervention;Knowledge;Lead;low and middle-income countries;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;Neural Network Simulation;novel;pandemic disease;Participant;patient oriented research;Patients;Persons;Pilot Projects;Population;Positioning Attribute;pre-trained model;predictive modeling;programs;prospective;Public Health;Qualifying;radiologist;Reader;Recommendation;Recording of previous events;Reporting;Research;research and development;Research Personnel;Resource-limited setting;Resources;Roentgen Rays;scale up;screening;sex;skills;South Africa;Sputum;statistics;Symptoms;System;Target Populations;Technology;Testing;Thoracic Radiography;tool;Training;Training Programs;transfer learning;Tuberculosis;Uganda;World Health Organization;X-Ray Medical Imaging

PROJECT_TITLE: Optimizing Implementation of Digital X-ray with Computer-Aided Detection for Community-Based Tuberculosis Screening

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mucopolysaccharidoses (MPS);Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE About 79% of mucopolysaccharidoses (MPS) patients develop spinal disorders that significantly impair physical functioning and whose early diagnosis may prevent irreversible neurological damage. The proposed research will examine cervical spinal cord morphology and microstructure in a large cohort of patients with MPS type I, II, and VI and identify structural measurements as candidates for markers of MPS severity and myelopathy risk. The study outcomes will guide the clinical decision process for spine surgery and impact the design of future clinical trials focusing on MPS patients’ overall and spinal cord health.

PI_NAMEs: LABOUNEK, RENE  (contact);NESTRASIL, IGOR

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adrenoleukodystrophy;Affect;Age;Analysis of Covariance;Area;Biological Markers;brain magnetic resonance imaging;Brain scan;candidate identification;candidate marker;Cervical;Cervical spinal cord structure;Cervical spine;Clinical;clinical predictors;Clinical Trials;cohort;comparison control;Data;Data Set;Databases;design;Diagnosis;Diameter;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Future;Goals;Health;Height;Image;improved;Inherited;innovation;Institution;Lysosomal Storage Diseases;Magnetic Resonance Imaging;Measurement;Measures;Methods;Modeling;Monitor;Morphology;MRI Scans;Mucopolysaccharidoses;Mucopolysaccharidosis I;Mucopolysaccharidosis II;Mucopolysaccharidosis III;Mucopolysaccharidosis VI;Nervous System Trauma;Neurologic;Neurological disability;Operative Surgical Procedures;Outcome;Outcome Study;Pathology;Patients;Phase;Physical Function;physical impairment;Population;pre-clinical;prevent;Process;prophylactic;public health relevance;Reading;Research;Research Proposals;Resolution;Risk;Sampling;Scanning;Severities;Severity of illness;sex;Signal Transduction;Spinal Cord;spinal cord compression;Spinal cord damage;Spinal Cord Diseases;spinal cord imaging;Spinal Diseases;Spine surgery;Stenosis;Structure;Symptoms;System;Testing;Validation;Visual;Weight

PROJECT_TITLE: Assessment of cervical spinal pathology in patients with MPS I, II and VI

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


PHR: PROJECT NARRATIVE Heart failure impacts more than 5 million Americans and is the leading cause of short term hospital readmissions. Current methods to detect cardiac failure decompensation at home rely on patient’s self-report and are lacking, motivating the need to develop non-invasive remote monitoring technology that could be widely disseminated to allow earlier intervention and reducing the rehospitalization rate. We propose to develop a wearable monitor that uses near-infrared light to detect excessive accumulation of water in tissue (edema) as well as impaired peripheral blood circulation and demonstrate its utility in pilot clinical study in patients with cardiac failure.

PI_NAMEs: CARP, STEFAN ALEXANDRU (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: absorption;Acute;Address;Adoption;Affect;American;analog;Ankle;Area;Blood;Blood Circulation;Body Weight decreased;Cardiac;Cardiac Output;Catheters;Chronic;Clinical;Clinical assessments;Clinical Research;Clinical Trials;common symptom;Compensation;Congestive Heart Failure;cost;Custom;Dedications;Detection;Development;Devices;Early Intervention;Edema;Etiology;Event;Fluid overload;Frequencies;Future;Health Expenditures;Health Personnel;healthy volunteer;Heart;Heart failure;hemodynamics;Hemoglobin;Home;hospital readmission;Hospitalization;Hospitals;Hydrogels;Impairment;improved;instrumentation;Intervention;Left;Leg;Life;Light;Lower Extremity;Measurement;Measures;Medical;Methods;Microcirculation;Monitor;monitoring device;Myocardium;Near-Infrared Spectroscopy;non-invasive monitor;Optics;Outcome;Oxygen;Patient Admission;Patient Self-Report;Patients;Perfusion;Peripheral;peripheral blood;Persons;Pharmaceutical Preparations;Physiological;Pilot Projects;pressure;Prevalence;Prevention;Preventive measure;Procedures;Property;pulmonary arterial pressure;Pulmonary artery structure;Pump;readmission rates;recruit;remote monitoring;Research;Resolution;Rest;Risk;secondary analysis;Severities;Shortness of Breath;Spectrum Analysis;Swelling;Symptoms;System;Technology;telehealth;Tissues;Titrations;Validation;Vascular Diseases;Water;wearable device;wearable monitor;Weight;Weight Gain;wireless

PROJECT_TITLE: Development of wearable monitor to detect decompensation in cardiac failure patients

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative The proposed research is relevant to public health because it will address quality of care issues associated with hearing loss in adults who have perceived mild-to-moderate hearing loss and who have no access to hearing healthcare. This project will identify a new care delivery model for adults living in rural communities of the Southern United States to mitigate the negative effects of hearing loss. This information is important to NIH’s mission because it will lead to options that will increase access and affordability of hearing healthcare for adults with mild-to-moderate hearing loss, a specific goal of NIDCD.

PI_NAMEs: BERENBROK, LUCAS ALLAN;HAY-MCCUTCHEON, MARCIA JEAN (contact);MORMER, ELAINE A

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Adult;Age;Alabama;Area;Caring;Censuses;Clinical;Clinical Services;Clinical Skills;Clinical Trials;Clinical Trials Design;Cognition;cohort;Collaborations;Communication;Communities;community partners;Community Pharmacy;Country;County;Data;Development;Devices;Diabetes Mellitus;Education;Educational Models;effectiveness study;Ensure;evidence base;experience;Goals;Guidelines;health care model;Healthcare;Hearing;Hearing Aids;hearing impairment;Household;Improve Access;Income;Inequity;innovation;interest;Medical;metropolitan;Mission;Mississippi;Modeling;multimodality;National Institute on Deafness and Other Communication Disorders;Nature;older adult;Older Population;Otolaryngologist;Outcome;Outcome Study;Patients;Performance;Pharmaceutical Services;Pharmacists;Pharmacy facility;point of care;Population;post intervention;programs;Public Health;Quality of Care;Quality of life;Reporting;Research;Resources;Rural;rural area;Rural Community;Rural Population;satisfaction;Service delivery model;Services;skills;socioeconomics;stem;Surveys;Technology;Testing;Training;Training and Education;Training Programs;United States;United States National Institutes of Health;Universities;urban area;Well in self;Work

PROJECT_TITLE: Increasing Access to Hearing Healthcare: An Assessment of Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Considering that many older adults from minoritized populations (e.g., Black/African American and Latinx/a/o, and socioeconomically disadvantaged adults) are disproportionally affected by Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD), it is critical to facilitate their representation in AD/ADRD research. The development and evaluation of efforts to increase the inclusion of minoritized populations in AD/ADRD research needs to be theory-based, informed by the respective community members, and consider intersecting social positions of populations. The training and research proposed by this K01 Mentored Research Scientist Career Development project will facilitate the development of evidence-based, community-engaged digital research inclusion efforts, which consider the intersection of ethnocultural identity and education in Black/African American and Latinx/a/o older adults, which is an important step in improving their representation in AD/ADRD research.

PI_NAMEs: ASHFORD, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;Adult;Advertisements;Affect;African American;Age;Alzheimer's Disease;Alzheimer's disease related dementia;behavior change;Behavior Control;Biological Markers;Black race;Blood;Brain Health Registry;career development;Characteristics;Chronic;Clinic;Clinical;Clinical Research;Cognitive;cognitive testing;cohort;Cohort Studies;Collaborations;Collection;communication behavior;Communities;community collaboration;community engaged approach;community engaged research;community science;Cross-Sectional Studies;Data;design;Development;digital;disadvantaged background;Education;Educational Background;Enrollment;Ensure;Equity;Ethics;Evaluation;evidence base;experience;Focus Groups;Generations;Goals;health assessment;health communication;health disparity;health equity;improved;Inequity;Infrastructure;innovation;Intention;interest;intersectionality;Intervention;Knowledge;Latina;Latino;Latinx;Measures;member;Mentors;Mentorship;Methods;Minority;Minority Groups;Modeling;multidisciplinary;neuroimaging;novel;older adult;online registry;optimism;outreach;Patient Self-Report;pilot test;Population;Psychosocial Factor;Public Health;Randomized;recruit;Reporting;Research;research and development;Research Design;Research Methodology;Research Personnel;research study;Respondent;Role;Safety;Sampling;Scientist;skills;social media;Social status;socioeconomic disadvantage;Surveys;theories;Theory of Change;Time;Training;Training Support;United States National Institutes of Health

PROJECT_TITLE: An intersectional community-engaged approach for improving the inclusion of minoritized older adults in Alzheimer’s disease research.

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biodefense and Related Countermeasures;Clinical Research;Dietary Supplements;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Nutrition;Rare Diseases;Rheumatoid Arthritis;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Antibiotic alteration of the gut microbiota can worsen the severity of inflammatory arthritis but how this occurs is not well understood. This proposal aims to extend our prior work to define how antibiotic-induced gut dysbiosis affects local responses in the gut epithelium and distal inflammation in the joint. This Mentored Clinical Scientist Research Career Development Award (K08) application proposes a research and career development plan over the next 5 years to allow the PI to study this important research question and develop the skills and training to become a successful, independent physician-scientist investigating the gut microbiome interface and the gut- joint axis.

PI_NAMEs: ZHAO, FANG  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;Alkaline Phosphatase;Alpha Virus;Antibiotic Therapy;Antibiotics;Arthritis;Arthritogenic;ATAC-seq;Attenuated;autoimmune arthritis;Autoimmune Diseases;Award;Bacteria;Bioinformatics;Biological Models;Biology;Brush Border;career;career development;cell type;chikungunya;Chikungunya virus;Chronic;Chronic Childhood Arthritis;Circulation;climate change;Clinical;Clinical Management;clinical training;Complex;cytokine;Data;Data Set;Development Plans;Distal;Doctor of Medicine;Doctor of Philosophy;Drug Metabolic Detoxication;dysbiosis;Enterocytes;Environment;Enzymes;epidemic virus;Epigenetic Process;Epithelial Cells;experience;fatty acid supplementation;Fellowship;Fibroblasts;Future;gastrointestinal epithelium;Gene Modified;Genetic Transcription;global health;Goals;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Heterogeneity;host microbiome;Immune;Immunology;imprint;improved;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Response;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;joint inflammation;Joints;K-Series Research Career Programs;Knowledge;Learning;Link;link protein;Lipopolysaccharides;Macrophage;Maintenance;Manuscripts;Mediating;medical schools;Mentors;Mentorship;Microbe;microbial;microbiome;microbiota;microbiota composition;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mucins;Mucous body substance;Mucous Membrane;Mus;next generation sequencing;novel therapeutic intervention;Oral;oral supplementation;pathogen;Pathway interactions;Patients;Pattern;Physicians;Population;Postdoctoral Fellow;Principal Investigator;Process;Production;programs;Publishing;Quality of life;Regulation;Relapse;Research;research and development;Research Personnel;Research Project Grants;Resolution;Resources;response;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Role;Scientist;Severities;Shapes;Signal Transduction;single-cell RNA sequencing;skills;Southeastern United States;Supplementation;Synovial Cell;Synovitis;T-Lymphocyte;Technology;tissue tropism;Tissues;TLR4 gene;Training;transcriptome;transcriptome sequencing;transcriptomics;Universities;vector mosquito;Viral Arthritis;Viral Load result;virtual;Volatile Fatty Acids;Washington;Work

PROJECT_TITLE: Role of the gut barrier in inflammatory arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Hematology;Lymphatic Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SPRINGFIELD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY SCH OF MED

ORG_STATE: IL

PHR: Project Narrative Lymph node metastasis strongly correlates with mortality of breast cancer patients. Metastasis depends on the density of lymphatic vessels determined by lymphatic endothelial progenitors. We will define the mechanisms generating these progenitors and regulating their unique ability to expand vessel network through fusion.

PI_NAMEs: RAN, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Adopted;Antibodies;Appearance;Blood;Bone Marrow;Breast Cancer Patient;Cancer Patient;Cell division;Cell fusion;cell injury;Cell Proliferation;Cells;Chimera organism;Clinical;clinically significant;Coculture Techniques;Color;Confocal Microscopy;cytokine;Data;density;Destinations;differentiation in vitro;Distant;endothelial stem cell;Endothelium;Event;Female;Generations;Genomics;High-Risk Cancer;Human;improved;In Vitro;in vivo;in vivo Model;Individual;Inflammatory;Interleukin-10;Interleukin-13;interleukin-13 receptor;Interleukin-4;Ligands;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;Lymphatic Metastasis;lymphatic vessel;Lymphatic Vessel Tumors;Macrophage;male;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic Neoplasm to Lymph Nodes;mortality;Mus;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nodal;novel;Nuclear;nuclear reprogramming;Organ;Outcome;overexpression;Pathway interactions;Patients;Phenotype;Play;prevent;progenitor;Property;Proteins;receptor;repaired;Role;stem;stem cell differentiation;Structure;Testing;TLR4 gene;trait;tumor;Tumor Cell Line;tumor microenvironment;tumor progression;Tumor Suppression;Tumor-associated macrophages;Vascular Endothelial Growth Factor Receptor-3;Wild Type Mouse;Y Chromosome

PROJECT_TITLE: Role of Th2 cytokines in progenitor-mediated formation of tumor lymphatics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Impaired extravillous trophoblast (EVT) cell development leads to early loss of pregnancy, a suboptimal fetal environment, and adverse pregnancy outcomes. Regulatory mechanisms underlying human trophoblast stem cell self-renewal and early events in the differentiation of EVT cells have largely remained elusive. The objective of this proposal is to elucidate the role of CCAAT/enhancer-binding protein beta in early events of EVT cell differentiation.

PI_NAMEs: MORENO, AYELEN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal placentation;Adult;adverse pregnancy outcome;Affect;Behavior;Binding;Biological Availability;CCAAT-Enhancer-Binding Protein-beta;Cell Differentiation process;Cell Lineage;Cells;ChIP-seq;Chromatin;cytotrophoblast;Data;Development;Disease;early detection biomarkers;early pregnancy loss;Endocrine;Environment;Event;fetal;Fetal Growth Retardation;Fetus;First Pregnancy Trimester;Foundations;gene regulatory network;Genome;Goals;Grant;Health;Human;Impairment;improved;In Vitro;Invaded;Kansas;Lead;lentiviral-mediated;Life;Medical center;Mentors;Morbidity - disease rate;mortality;Mothers;Pathology;Phase;Placenta;Placentation;Population;Post-Translational Protein Processing;postnatal;Pre-Eclampsia;Predisposition;Pregnancy;Pregnancy Complications;Premature Birth;Publications;Regulation;Research;Resources;response;Role;Series;single cell ATAC-seq;single-cell RNA sequencing;skill acquisition;skills;small hairpin RNA;Spiral Artery of the Endometrium;stem;stem cell population;stem cell self renewal;Supervision;Syncytiotrophoblast;Testing;Training;transcription factor;Transcriptional Regulation;trophoblast;trophoblast stem cell;Undifferentiated;Universities;Uterus;Vascular blood supply;Villous;virtual;Work;Writing

PROJECT_TITLE: Early Events in Extravillous Trophoblast Cell Differentiation

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Sex differences in mood disorders during cocaine abstinence may be influenced by the interplay between estrogen (E2) and L-type calcium channel (LTCC) interactions. The current study will conduct an extensive mechanistic analysis to investigate whether E2, in conjunction with LTCCs, significantly impacts drug-seeking and mood-related behaviors following cocaine abstinence. Understanding the impact of estrogen on potential L-type calcium channel mechanisms involved in comorbid substance use and mood disorders holds both innovative potential and the promise of reshaping our approach to these co-occurring conditions.

PI_NAMEs: ADDY, NII A (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;Anti-Anxiety Agents;anti-depressive agents;Anxiety;Anxiety Disorders;associated symptom;Attenuated;Behavior;behavioral pharmacology;Brain;Chronic;Chronic stress;Cocaine;Cocaine Dependence;cocaine exposure;comorbidity;Disease;Dopamine;drug abstinence;drug of abuse;drug seeking behavior;Electrochemistry;Estrogens;Exposure to;Female;Genes;High Prevalence;Human;improved;in vivo;Individual;innovation;Intravenous;Knowledge;L-Type Calcium Channels;Major Depressive Disorder;male;Mediating;Mental Depression;Mood Disorders;Moods;neuropsychiatric disorder;novel;novel therapeutic intervention;Nucleus Accumbens;Pathway interactions;Pharmaceutical Preparations;Phenotype;Rattus;Regulation;Research;Rewards;risk variant;Rodent Model;Self Administration;Sex Differences;Shapes;Signal Transduction;social deficits;Social Interaction;Stress;Substance abuse problem;substance use;Substance Use Disorder;Symptoms;therapeutic target;therapeutically effective;Ventral Tegmental Area

PROJECT_TITLE: L-Type Calcium Channel Mechanisms Mediating Comorbid Substance Use and Mood Disorders


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: KALAMAZOO

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

ORG_STATE: MI

PHR: Narrative B cells have been thought to be absent from the central nervous system, but recently B cells have been shown to be present in cerebral spinal fluid (that bathes the brain) of normal healthy human volunteers, which could be a problem because although B cell produce protective antibodies they can also generate autoreactive antibodies that have the capacity to damage normal tissues. We have shown that in young people B cells in the central nervous system do not overlap with, or come from, the bloodstream, meaning that B cells in the central nervous system are completely separate and distinct from circulating B cells-- work by another group similarly finds that circulating B cells do not enter the central nervous system in young mice; however, the situation in old mice is completely different in that peripheral B cells are, in fact, found within the central nervous system. We will determine whether migration/translocation of peripheral B cells to the central nervous system occurs in old people because, if so, B cells making autoantibodies that cross over to, and end up in, the central nervous system could participate in the pathogenesis and/or progression of age-associated neurodegenerative diseases that involve inflammation and this new understanding might lead to new approaches for disease prevention or treatment.

PI_NAMEs: ROTHSTEIN, THOMAS L (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;age related;age related neurodegeneration;Aging;Alzheimer's Disease;animal old age;Animals;Antibodies;Antibody Repertoire;Antigens;Apoptotic;arm;Autoantibodies;Autoimmune;autoimmune inflammation;autoreactive B cell;autoreactivity;B cell repertoire;B-Lymphocytes;Bathing;Blood - brain barrier anatomy;Blood Circulation;Brain;cell behavior;Central Nervous System;Cerebrospinal Fluid;Clinical;Cognitive aging;Communication;design;Disease;disorder prevention;Dysplasia;Elderly;Functional disorder;Future;Generations;Goals;healthy volunteer;Human;human old age (65+);Human Volunteers;Immune;Immune system;Immunoglobulins;Individual;Infection;Inflammation;Investigation;juvenile animal;Knowledge;Leukocytes;migration;Molecular;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;neuropathology;Normal tissue morphology;novel;novel strategies;old mice;Older Population;pathogen;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peripheral;peripheral blood;Peripheral Nervous System;Persons;Phenotype;Physiology;Play;Population;prevent;Process;Production;receptor;Reporting;Resolution;Risk;Role;Sampling;Self Perception;Sequence Analysis;Site;Sorting;Stains;Stochastic Processes;Testing;Time;Tissues;virtual;Work

PROJECT_TITLE: Intermingling of circulating B cells and cerebral spinal fluid B cells with advancing age

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]