NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Human Genome

PI_NAMEs: KOUSOULAS, KONSTANTIN G (contact)

PROJECT_TERMS: Adopted;animal imaging;animal tissue;anti-cancer research;bioimaging;Bioinformatics;Biological;Biological Assay;Biomedical Research;Biotechnology;Cell Culture Techniques;Cell Separation;Cells;Cellular biology;Centers of Research Excellence;Collaborations;Computer software;Computers and Advanced Instrumentation;Consult;Consultations;Contract Services;Core Facility;cost;course module;CRISPR/Cas technology;Data;Disease;disease model;Electron Microscopy;Ensure;Equipment;Experimental Designs;experimental study;Faculty;Faculty Recruitment;Funding;Gene Expression;Genomics;Genus Hippocampus;Goals;Human;Human Resources;Immunofluorescence Microscopy;Immunologics;Immunology;immunopathology;improved;in vivo;instrumentation;interest;Investigation;Laboratories;Leadership;Life;Louisiana;Maintenance;Malignant Neoplasms;Measurement;Measures;Methodology;Methods;Molecular;Molecular Biology;Molecular Medicine;Monoclonal Antibodies;nano-string;new technology;novel therapeutic intervention;Pathology;Patients;pre-clinical;preclinical evaluation;predictive modeling;Productivity;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Reagent;repaired;Research;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;Science;Services;single cell sequencing;spheroids;Students;Technical Expertise;Technology;Time;Tissue Sample;tissue/cell culture;Training;Training Activity;Training and Education;transcriptome sequencing;transcriptomics;Treatment outcome;United States National Institutes of Health;Universities;Update;Veterinary Medicine;Veterinary Schools;Viral Vector;Work

PROJECT_TITLE: Molecular Biology and Immunopathology Core


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The proposed research concerns mechanisms by which immature egg cells, or oocytes, develop the ability to mature into fertilizable eggs that can undergo successful embryonic development. This research will advance knowledge of crucial physiological processes, and establish a basis for future clinical developments, especially in treatment of infertility.

PI_NAMEs: MEHLMANN, LISA M (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acute;Antibodies;Appearance;Area;assisted reproduction;Biology;Cell membrane;Cells;clinical development;Competence;Cytoplasm;Cytoplasmic Granules;Cytoplasmic Protein;Development;Disease;early pregnancy loss;egg;Embryo;Embryonic Development;Endoplasmic Reticulum;Environmental Risk Factor;Event;Exocytosis;experimental study;extracellular;Family;Fertilization;Fluorescent Probes;Future;Growth;Human;improved;In Vitro;infertility treatment;Knowledge;Label;Meiosis;Meiotic Prophase I;Metaphase;Methods;Molecular;Movement;Mus;Nuclear;oocyte maturation;oocyte quality;Oocytes;Ovary;ovulation time;Physiological Processes;Pituitary Gland;Pituitary Hormones;poor egg quality;Prevention;Process;Production;Prophase;Protein Biosynthesis;protein degradation;protein transport;Proteins;Puberty;rapid technique;Regulation of Exocytosis;Reproductive Health;Research;response;RNA Interference;Role;Secretory Cell;Signal Transduction;Site;Small Interfering RNA;sperm cell;Structure;success;syntaxin;Testing;Time;translational applications;uptake;Visualization;Woman;zygote

PROJECT_TITLE: Cytoplasmic Maturation in Mouse Oocytes

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Chronic Pain;Genetics;Osteoarthritis;Pain Research;Precision Medicine;Prevention

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Osteoarthritis (OA) is a common disease causing degeneration of the joints. It is complex with patients presenting with variable clinical indications. However, treatment strategies are limited to helping of only some symptoms such as pain, but not changing the course of the underlying disease. We propose an analysis extracellular RNA signatures that contribute to OA clinical subtypes and progression pattern unique to an individual. Using clinical phenotype clustering and plasma extracellular RNA expression signatures, our study may suggest novel molecular contributors to the disease and options for targeted therapeutics. Such functional biomarker identification can then be widely applied across OA phenotypes and populations to bring precision diagnosis and potential therapies to a broad section of those suffering from this disease.

PI_NAMEs: BEST, THOMAS MICHAEL;GRISWOLD, ANTHONY JOHN (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Affect;Age;aging population;American;Architecture;arthropathies;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker identification;Body mass index;Categories;Chronic Disease;Classification;Clinical;Clinical Data;clinical data repository;clinical phenotype;clinical subtypes;cohort;Cohort Studies;Complex;Data;Degenerative polyarthritis;Development;Diagnosis;Diagnostic;Disease;disease heterogeneity;Disease Progression;disorder risk;disorder subtype;effusion;experimental study;extracellular;Failure;functional genomics;Gene Expression Profile;Genes;Genetic;Genetic Markers;Genetic Techniques;Genetic Transcription;genomic signature;Genomics;Heart Diseases;Heterogeneity;High-Throughput RNA Sequencing;Image;Incidence;Individual;insight;joint destruction;Knee Osteoarthritis;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Methodology;Methods;MicroRNAs;Molecular;Molecular Genetics;molecular marker;Molecular Profiling;Multiple Sclerosis;muscle strength;novel;Pain;pain symptom;Pathway interactions;Patients;Pattern;Phenotype;Physiological Processes;Plasma;Population;precision medicine;Prevalence;prevent;prognostic;progression marker;prospective;Public Health;Questionnaires;radiological imaging;Resources;Risk Factors;risk stratification;RNA;Roentgen Rays;Role;Sampling;sex;Signaling Molecule;specific biomarkers;Statistical Data Interpretation;Stress;Symptoms;targeted treatment;Therapeutic;Therapeutic Intervention;Time;Tissues;treatment strategy

PROJECT_TITLE: Extracellular RNA Expression Biomarkers in Osteoarthritis Disease and Progression

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Most diseases are due to inflammation that is maladaptive—damaging host tissues. The vast majority of the damage takes place after white blood cells cross blood vessels (transendothelial migration) to enter the inflamed tissues. We are studying how this process is regulated and how it contributes to disease progression and resolution, so that we can design better anti-inflammatory therapies to control it.

PI_NAMEs: MULLER, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: Acute;Adhesions;Affect;Anti-Inflammatory Agents;Biochemical;Blood Vessels;CD31 Antigens;Cell Line;Chronic;Circulation;Data;Dendritic Cells;design;Disease;Disease Progression;Endothelial Cells;Endothelium;Genetic;Health;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Knockout Mice;Lateral;Leukocytes;Lung;Membrane;Microtubules;migration;Modeling;monocyte;Movement;neutrophil;postcapillary venule;Process;Reagent;Recycling;Resolution;Reticulum;Role;Seminal;Signal Pathway;Signaling Molecule;Site;Study models;Surface;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;tool;vascular bed;Work

PROJECT_TITLE: Transendothelial Migration of Leukocytes:  Developing New Paradigms in Health and Disease


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: RELEVANCE Positron-emission tomography (PET) provides the best method to probe the dynamic status of receptors and other targets in the living brain to understand the brain in health, disease, and aging. Though many targets can already be imaged today, there is a continuous need to improve the performance of existing assays, to develop probes for newly discovered targets, or to label probes with new isotopes (e.g. F-18 instead of C-11). This project aims to develop new high-throughput tools that will dramatically accelerate these new probe development efforts.

PI_NAMEs: CHATZIIOANNOU, ARION XENOFON;VAN DAM, ROBERT MICHAEL (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Aging;Automation;base;Biodistribution;Biological;Biological Assay;Brain;Chemicals;Chemistry;Clinical;clinical imaging;clinically relevant;Collection;Consumption;cost;Creativeness;Decontamination;design;Development;Disease;Disease Progression;Dose;Ensure;Equipment;Exclusion;experimental study;Exposure to;Health;high throughput technology;human error;Image;imaging approach;imaging study;improved;In Situ;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Individual;Infrastructure;Injections;innovation;Investigation;Isotopes;Label;Lead;Liquid substance;Manuals;Measurement;Methods;Mole the mammal;new technology;novel;novel therapeutics;operation;Pathway interactions;Patients;Performance;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;Preparation;pressure;Process;Production;Property;prototype;radiation detector;Radiation exposure;Radio;Radioactive;Radioactivity;radiochemical;Radiochemistry;Radioisotopes;Rapid screening;rapid technique;Reaction;Reagent;receptor;Research;Research Personnel;Safety;Sampling;scale up;screening;Sensory Receptors;Site;Speed;Spottings;System;targeted imaging;Technology;Time;Tissues;tool;Tracer;Work

PROJECT_TITLE: Accelerating the discovery and development of neurotracers via high-throughput radiochemistry

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: AI

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Infectious Diseases;Orphan Drug;Primary Immunodeficiencies;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Significance of modulating neutrophil extracellular trap (NET) formation, a relative newly discovered aspect of neutrophil activation in respiratory and inflammatory disease conditions is now well recognized. Our proposed studies elucidate a novel autophagy-mediated, ROS independent NET formation pathway activated by Tamoxifen, a breast cancer drug, in ROS-deficient neutrophils and its implications in pulmonary infections in Chronic Granulomatous Disease (CGD). Validation of this drug and its target pathway will have significant impact on therapeutic measures to correct the neutrophil dysfunction in airway diseases.

PI_NAMEs: SHARMA, JYOTIKA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Acceleration;Acute;acute infection;Airway Disease;Anti-Bacterial Agents;Antiinflammatory Effect;antimicrobial;Antineoplastic Agents;Autoimmune Diseases;Autophagocytosis;Bacterial Infections;Blood specimen;Breast Cancer Treatment;Bypass;Chromatin;Chromatin Fibril;Chronic;Chronic Granulomatous Disease;chronic infection;clinical center;Clinical Trials;cohort;Colitis;Colon;combat;Communicable Diseases;Complex;Cysteine;Data;Defect;dextran sulfate sodium induced colitis;Disease;Estrogen Receptors;Exhibits;experimental study;extracellular;FDA approved;Functional disorder;Future;gastrointestinal;gene therapy;Generations;Genetic Transcription;Histones;Human;Immune response;Immunity;Impairment;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;insight;Lamin B1;Life;Link;Lung;Lung infections;Malignant Breast Neoplasm;Measures;Mediating;Molecular;Mus;Mutation;NADPH Oxidase;neutrophil;Neutrophil Activation;new therapeutic target;novel;Nuclear Lamina;pathogen;pathogenic bacteria;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Phagocytes;Phagocytosis;Pharmaceutical Preparations;pre-clinical;pre-clinical research;Preclinical Testing;Predisposition;Proteins;Publications;Publishing;ran-binding protein 1;Reactive Oxygen Species;recurrent infection;Reporting;Research;Respiratory Burst;Respiratory Disease;response;Role;Seminal;Signal Pathway;Stimulus;Tamoxifen;targeted treatment;Testing;Therapeutic;United States National Institutes of Health;Validation

PROJECT_TITLE: Neutrophil Extracellular Traps and Host Immunity

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: A national public health emergency has been declared to combat the current opioid crisis. We propose to use a rat model to identify genetic factors that predispose individuals to oxycodone abuse and aberrant stress response.

PI_NAMEs: CHEN, HAO  (contact);MULLIGAN, MEGAN KATHLEEN

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: abuse liability;addiction;Affect;Analgesics;Animal Model;Animals;Automobile Driving;Backcrossings;Behavioral;biological adaptation to stress;Brain region;Breeding;Candidate Disease Gene;candidate identification;causal variant;Cessation of life;Chromosome Mapping;Clinical;combat;comorbidity;Consumption;controlled release;Corticosterone;Data;depression model;design;Development;Dose;drug action;Drug Addiction;drug seeking behavior;Drug usage;Female;Future;Gene Expression;Genes;Genetic;genetic approach;Genetic Polymorphism;genetic risk factor;Genetic study;genetic variant;Genome;genome editing;genome sequencing;genome wide association study;Genotype;Glucocorticoid Receptor;Goals;Heritability;Hippocampus;Hormones;Human;Human Genetics;in vivo;Inbred Strains Rats;Inbred WKY Rats;Inbreeding;Individual;Intake;Knock-in;Location;male;Maps;Modeling;motivated behavior;multiple data types;Mutation;novel strategies;Nucleus Accumbens;offspring;Opiate Addiction;Opioid;opioid abuse;Opioid abuser;Opioid Analgesics;opioid epidemic;opioid misuse;opioid use disorder;opioid withdrawal;Oral;Overdose;Oxycodone;oxycodone seeking;oxycodone self-administration;Pattern;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Population;power analysis;Prefrontal Cortex;prescription opioid;Prescription opioid overdose;Prevalence;public health emergency;Quantitative Trait Loci;Rat Transgene;Rattus;receptor;Regulation;Research;response;Risk Factors;Rodent;segregation;Self Administration;Sex Differences;Site;spatiotemporal;Stress;study population;success;System;Tablets;Time;trait;transcriptome sequencing;Transgenes;Transgenic Organisms;Translating;Variant;Ventral Tegmental Area;Viral Vector;whole genome;Withdrawal

PROJECT_TITLE: Reduced complexity mapping of oxycodone self-administration and stress responsiveness in rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GHD-P(07)S]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Narrative The goal of this research effort is to develop novel and versatile computational methods for deriving quantitative understanding of the molecular basis of disordered proteins and dynamic interactions in biomedically important processes. Through strategic experimental collaborations, new insights will be generated for addressing fundamental and biomedical questions related to signaling, cancer, protein misfolding, protein aggregation and innate immunity. 2

PI_NAMEs: CHEN, JIANHAN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Antineoplastic Agents;Area;Biological;Biology;Biomedical Research;Cells;Collaborations;Complex;Computing Methodologies;coping;Decision Making;Diabetes Mellitus;Disease;Epigallocatechin Gallate;Family;Feedback;Flavivirus;Goals;Heart Diseases;Human;human disease;Immune;insight;Length;Malignant Neoplasms;Measurement;Mediating;method development;Methodology;Methods;models and simulation;Molecular;Molecular Chaperones;Molecular Conformation;molecular modeling;Mutation;Names;Natural Immunity;Neurodegenerative Disorders;novel;Peptide Hydrolases;Peroxidases;Pharmaceutical Preparations;Phosphorylation Site;Play;Prevalence;Process;Property;protein aggregation;Protein Dynamics;protein folding;protein function;protein misfolding;protein protein interaction;protein structure function;Proteins;Research;Role;Signal Transduction;simulation;Staphylococcus aureus;Structure;System;Testing;Therapeutic;Time;TP53 gene;Transactivation;virtual;Virulence

PROJECT_TITLE: Disordered Proteins and Dynamic Interactions in Biology and Diseases.

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The incidence of acute kidney injury (AKI) is increasing worldwide, and is associated with high mortality, morbidity, and risk of chronic kidney disease. As a consequence of gaps in our understanding of the pathophysiology of AKI, adverse effects of pharmacological agents, and a lack of data using good animal models, effective treatment for AKI remains elusive and no approved pharmacological agents exist for the prevention or treatment of AKI. This proposal aims to evaluate the effect of enhancing removal of dying cells on AKI and assess the therapeutic potential of targeting efferocytosis for kidney injuries.

PI_NAMEs: MORIOKA, SHO  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Adverse effects;Affect;Animal Model;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Area;Award;Bilateral;Biological Assay;Biological Models;Blood Urea Nitrogen;Bone Marrow;Bromodeoxyuridine;cadherin 5;career development;Cell Line;Cell Proliferation;cell regeneration;cell type;Cells;Cessation of life;Chimera organism;Chronic;Chronic Kidney Failure;Clinical;Creatinine;cytokine;Data;Defect;Dendritic Cells;design;Development Plans;Disease;disease model;Eating;effective therapy;Endothelial Cells;Epithelial Cells;Excision;Fibrosis;Foundations;Functional disorder;Funding;Glomerular Filtration Rate;Goals;Hematopoietic;Human;Human body;Immunology;In Vitro;in vivo;in vivo regeneration;Incidence;Individual;Induction of Apoptosis;Inflammation;Inflammatory;inflammatory milieu;Injections;Injury;Injury to Kidney;innovation;Ischemia;Kidney;Kidney Diseases;Knowledge;Laboratories;Lead;Link;Macrophage;Mentored Research Scientist Development Award;Mentors;Modeling;Monitor;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Nature;Necrosis;Nephrology;neutrophil;novel;Organ;Pathology;Patients;Phagocytes;Phagocytosis;pharmacologic;Physiology;Plasma;Population;Positioning Attribute;Pre-Clinical Model;preclinical study;Prevention;Process;receptor;Reperfusion Injury;Reperfusion Therapy;Research;research and development;Research Personnel;Resolution;Risk;Rodent;S100A8 gene;Sampling;skills;Source;System;Testing;Therapeutic;Time;tissue injury;Training;Training Programs;Transgenic Mice;Tubular formation;United States National Institutes of Health;Universities;Virginia;Work;wound

PROJECT_TITLE: Removal of apoptotic cells during acute kidney injury

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Cancer;Liver Disease;Nutrition;Obesity;Rare Diseases

ORG_CITY: BATON ROUGE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PI_NAMEs: JOHNSTON, ANDREA NOEL (contact)

PROJECT_TERMS: 3-Dimensional;Affect;anti-cancer research;Bioenergetics;Biogenesis;biomarker identification;bioprinting;Brown Fat;carcinogenesis;Cell Death;Cells;Cellular Spheroids;Colon Carcinoma;comparison control;Complex;Data;Defect;Development;diet-induced obesity;Doctor of Philosophy;fatty acid oxidation;Fatty Liver;Fluorouracil;Functional disorder;Gene Expression;Genetic Transcription;Genus Hippocampus;glucose tolerance;Glycolysis;Hepatic;Hepatic Stellate Cell;Hepatic Tissue;hepatocellular carcinoma cell line;Hepatocyte;HepG2;High Fat Diet;Homeostasis;Human;Hybrid Cells;In Vitro;in vivo;Inflammatory;Injury;insight;insulin sensitivity;interest;knock-down;Knock-out;Knockout Mice;Left;Link;lipid biosynthesis;lipid metabolism;Lipids;lipine;live cell imaging;Liver;Liver diseases;Liver Mitochondria;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;Mediator;Metabolic Pathway;metabolic phenotype;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Membrane Protein;mitochondrial metabolism;Modeling;molecular imaging;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nutrient;Obesity;Obesity Epidemic;Outcome;overexpression;Oxidants;Oxidation-Reduction;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Phosphoglycerate Mutase;Phosphoric Monoester Hydrolases;Population;pre-clinical;prevent;Primary carcinoma of the liver cells;Production;Proteins;Publications;Rattus;Reactive Oxygen Species;Regulation;Research;Respiration;respiratory;Risk Factors;Role;Serine;Serum;single cell sequencing;single-cell RNA sequencing;spheroids;survival outcome;Survival Rate;Testing;Therapeutic;therapeutic target;Thermogenesis;Threonine;transcriptomic profiling;Treatment outcome;Triglycerides;tumor growth;tumorigenesis

PROJECT_TITLE: Phosphoglycerate mutase 5 (PGAM5) in the regulation of hepatic lipid metabolism and carcinogenesis


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Mental Health;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative We propose to develop a research collaboration with individuals with craniofacial microsomia, their caregivers, craniofacial healthcare providers, and advocacy group leaders to evaluate the psychological health status and healthcare experiences of individuals with CFM and their caregivers. In a large international population affected by CFM, we will examine the extent to which current healthcare provision addresses the areas of health and psychological concern, identify of predictors of psychological distress, and identify opportunties for future interventions. The results of this study will enable further research on the healthcare outcomes and opportunties to perform targeted interventions to improve health in patients with craniofacial conditions.

PI_NAMEs: HEIKE, CARRIE LYN (contact);STOCK, NICOLA

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: Acceleration;Address;Adolescent;Advocacy;Advocate;Affect;Amendment;Area;Breathing;care burden;care outcomes;Caregivers;Cephalic;Child;cleft lip and palate;Clinical;Clinical Data;Clinical Research;Code;Collaborations;Communities;Complex;cost;Country;craniofacial;craniofacial microsomia;Data;Databases;design;Development;Diagnosis;distraction;Distress;Ear;Education;Evaluation;experience;Face;Foundations;Future;General Population;Goals;Growth;Health;health care model;Health Personnel;Health Professional;Health Status;Healthcare;healthcare burden;Hearing;Hearing Aids;Heart;Holistic Health;improved;Individual;informant;International;International Classification of Diseases;Intervention;Interview;Investigation;Jaw;Kidney;Knowledge;Live Birth;malformation;Mandible;Medical;Mental Health;Methodology;Methods;microtia;neurodevelopment;Nomenclature;nutrition;optimism;orofacial cleft;Outcome Measure;Participant;Pathway interactions;Patient Outcomes Assessments;Patients;Population;psychologic;psychological distress;Psychosocial Assessment and Care;reconstruction;Registries;Research;Research Project Grants;Screening procedure;social health determinants;Social support;Standardization;Structure;Survey Methodology;Techniques;Testing;Update;Variant;Vertebral column;Vulnerable Populations;young adult

PROJECT_TITLE: Craniofacial microsomia: Accelerating Research and Education (CARE)

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Precision Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Existing large data sets consisting of multi-platform genomic summaries of patient tumors contain rich information that may be useful for personalizing therapy to each individual's cancer, but there is a need for new analytical methods to fully extract the knowledge contained in these data. We will develop new integrative, network-based statistical methods that can uncover mechanistic biological information explaining the speci c characteristics of an individual patients cancer. We will apply these methods to four colorectal cancer data sets to deeply characterize four recently discovered subtypes of this cancer in order to identify new targeted therapeutic strategies that can lead to improved outcomes for colorectal cancer patients.

PI_NAMEs: BALADANDAYUTHAPANI, VEERABHADRAN ;MORRIS, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;active method;analytical method;Area;arm;Bayesian Network;Biological;Biological Factors;Biological Process;Cancer cell line;Cancer Patient;cancer subtypes;Cell Line;Characteristics;Clinical;Clinical Research;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;colon cancer patients;Colorectal Cancer;Communities;Complex;Computer software;Consensus;Data;data platform;Data Set;data sharing;Disease;DNA Sequence Alteration;Drug Targeting;Encyclopedias;Epigenetic Process;Follow-Up Studies;Formulation;Free Will;Genes;Genetic;Genetic Markers;genomic data;genomic platform;Genomics;Graph;Heterogeneity;Immune;improved outcome;Individual;individual patient;Knowledge;large datasets;Letters;Link;Literature;Malignant Neoplasms;Mediation;Mediator;Messenger RNA;Methods;Modeling;Modernization;Molecular;molecular subtypes;Mutation;network models;Network-based;new therapeutic target;novel;Oncogenic;Pathway interactions;Patient Selection;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;precision medicine;Precision therapeutics;preclinical study;Prediction of Response to Therapy;Process;rare cancer;Research;Research Personnel;Resource Sharing;response;Running;statistical learning;Statistical Methods;Structure;success;targeted treatment;Techniques;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;tool;Training;tumor;University of Texas M D Anderson Cancer Center;usability;Validation;web portal;Work

PROJECT_TITLE: Bayesian Network-Based Integrative Genomics Methods for Precision Medicine

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Neurosciences;Rare Diseases

ORG_CITY: BAYAMON

ORG_NAME: UNIVERSIDAD CENTRAL DEL CARIBE

ORG_STATE: PR

PHR: This project is aimed at improvement of glioblastoma (GBM) therapeutic strategies, taking into consideration the supporting role of tumor infiltrating myeloid cells on tumor progression and treatment resistance. The studies will elucidate the Pyk2-dependent machinery of cytokines release through the extracellular vesicles (EVs) mechanism in GBM cells, Pyk2 dependent populations of tumor-derived EVs and their effect on tumor infiltrating myeloid cells activation. The results of the study will help to identify molecular targets for managing tumor immune microenvironment and to enhance current GBM treatment protocols.

PI_NAMEs: KUCHERYAVYKH, LILIA  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Actins;Address;Affect;Biogenesis;brain tissue;C57BL/6 Mouse;Calpain;CCL2 gene;CCR5 gene;CD8-Positive T-Lymphocytes;CD81 gene;CD86 gene;Cell Culture Techniques;Cell Line;Cell membrane;Cell surface;Cells;Cellular biology;Cellular Structures;chemokine;Communication;Coupled;CRISPR/Cas technology;cytokine;Diagnosis;Diameter;Endosomes;Endothelial Growth Factors;Epidermal Growth Factor;Excision;extracellular vesicles;Flow Cytometry;Gene Expression Regulation;gene repression;Glioblastoma;Glioma;Goals;Golgi Apparatus;Growth Factor;Guanosine Triphosphate;Human;Immunofluorescence Immunologic;Immunologic Markers;implantation;improved;in vitro Model;Infiltration;Inflammatory;inhibitor;Integrins;Knock-out;Label;Laboratories;Life Extension;Malignant neoplasm of brain;MAPK8 gene;Mediating;Messenger RNA;Microglia;MMP14 gene;Modeling;Molecular Sieve Chromatography;Molecular Target;Monocyte Chemoattractant Proteins;mouse model;Mus;Myeloid Cell Activation;Myeloid Cells;myosin light chain 2;neoplastic cell;pharmacologic;polarized cell;Population;Prognostic Marker;PTK2 gene;PTK2B gene;RANTES;Regulation;Reverse Transcriptase Polymerase Chain Reaction;rho;Role;Signal Transduction;Specimen;STAT3 gene;temozolomide;Testing;Therapeutic;therapy resistant;TNF gene;Treatment Protocols;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor-Derived;tumor-immune system interactions;Up-Regulation;uptake;Vascular Endothelial Growth Factors;vesicular release;Western Blotting

PROJECT_TITLE: Pyk2 regulates extracellular vesicles release in GBM cells and modulates activation of tumor infiltrating myeloid cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-J (80)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention

ORG_CITY: BURLINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: This project will bring new understanding about how brain functioning in older adults is affected by a short term manipulation of the dietary ratio of the principal saturated fat and monounsaturated fatty acids (palmitic acid and oleic acid). The relationship among brain functioning and dietary fat composition will be studied. These data will have implications for understanding mechanisms underlying how diet influences brain functioning that is relevant to normal as well as pathological brain aging.

PI_NAMEs: DUMAS, JULIE A (contact);KIEN, CRAIG LAWRENCE

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Acute;Adult;Affect;age related cognitive change;aged;Aging;aging brain;Alzheimer's Disease;American diet;Behavior;Behavioral;Brain;Cognition;Cognitive;cognitive function;Cross-Over Studies;Data;Dementia;Diet;dietary;dietary control;Dietary Fats;Dietary Fatty Acid;dietary manipulation;Dietitian;drug action;Ensure;executive function;Fatty acid glycerol esters;Fatty Acids;Food;Functional Magnetic Resonance Imaging;Human;Impaired cognition;improved;improvement on sleep;Ingestion;insulin secretion;Intake;Investigation;Life;Lipids;Low-Density Lipoproteins;Measures;Mediterranean Diet;Memory;men;mild cognitive impairment;Monounsaturated Fatty Acids;Moods;Neurologic;novel;older adult;older men;older women;Oleic Acids;Outcome Measure;Palmitic Acids;Pathologic;Patients;Performance;Physical activity;Positioning Attribute;pre-clinical;pre-clinical research;primary outcome;Procedures;Quality of life;Recommendation;Rest;Safety;saturated fat;Saturated Fatty Acids;secondary outcome;Serum;Short-Term Memory;Sleep;Stress;Testing;Time;trend;Water;Woman;Work;young adult

PROJECT_TITLE: Fatty Acid Modulation of Brain Function in Older Adults

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Social Determinants of Health

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE: Emerging evidence demonstrates the importance of not just looking at genetics or the environment but rather, the interactions between genetic diversity and environmental exposures influencing human health and disease, including sensory processing disorders associated anxiety, autism, and schizophrenia. The etiology of sensory processing disorder remains equivocal; however, it is hypothesized that environmental factors including exposures to environmental contaminants can be important. This proposal uses a novel and powerful new model, the medaka fish, for determining gene- environment interactions that contribute to deficits in sensory processing behaviors observed with neuro-psychiatric conditions.

PI_NAMEs: KULLMAN, SETH WILLIAM (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acoustics;Affect;Alleles;Animals;Anxiety;autism spectrum disorder;Behavior;Behavioral;behavioral phenotyping;behavioral response;behavioral study;Biological;biological adaptation to stress;Biological Assay;Brothers;Chemicals;Chromosome Mapping;clinically relevant;Complex;Decision Making;Defect;developmental neurotoxicity;developmental toxicity;Disease;Dose;Environment;environmental change;Environmental Exposure;Environmental Pollutants;Environmental Risk Factor;Etiology;Exposure to;Fertility;Fishes;gene environment interaction;Generations;Genes;Genetic;Genetic Variation;Genome;genomic locus;Genomics;Goals;Health;Human;improved;Inbreeding;Incentives;Individual;insight;Joints;Life;Link;Linkage Disequilibrium;Maps;Methods;Modeling;Molecular;Motor;motor behavior;Mus;Nervous System Physiology;neuropsychiatry;neurotoxic;neurotoxicity;Neurotoxins;novel;Organism;Oryziinae;Outcome;Parents;Partner in relationship;Pathway interactions;Phenotype;Play;Population;Process;Research;Resources;response;Risk;Role;safety assessment;Schizophrenia;segregation;Sensory;Sensory Process;sensory processing disorder;Sister;Startle Reaction;Stress;teleost;Testing;trait;transcriptome;Variant;Vertebrates;visual motor;Zebrafish

PROJECT_TITLE: Gene by Environment Interactions in Sensory Processing Deficits

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-S (CP)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Listening effort and fatigue present major challenges for individuals with hearing loss, often leading to anxiety and social disengagement. This proposal focuses on how effort and fatigue are affected by factors relevant to real-world communication: the ability to see a talker’s face, the need to overcome cognitive and acoustic speech perception challenges, and the demands of participating in live conversation. Findings will inform the development of tools to diagnose and manage listening effort and fatigue that better reflect everyday communication experiences.

PI_NAMEs: FLEMING, JUSTIN TRACY (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Affect;Age;Anxiety;audiovisual speech;Behavior;Blindness;Bypass;Clinic;Clinical;Cochlear Implants;Cognitive;Communication;Cueing for speech;Cues;Data;Diagnosis;diagnostic development;Diagnostic tests;Equilibrium;experience;experimental study;Eye;Face;face mask;Fatigue;Future;gaze;Goals;Head;hearing impairment;improved;indexing;Individual;Individual Differences;Laboratory Study;Link;Literature;Masks;Measures;Methods;multisensory;Noise;normal hearing;ophthalmic examination;Oral cavity;Participant;Pattern;Perception;Persons;Physiological;preservation;pressure;Psyche structure;Pupil;Quality of life;Reaction Time;rehabilitation strategy;repaired;Research;Sampling;social;social communication;social engagement;Social Environment;Social Interaction;Speech;Speech Acoustics;speech in noise;Speech Intelligibility;Speech Perception;Stimulus;Testing;Time;tool development;Translating;Uncertainty;usability;video chat;Video Recording;Visual;visual speech;visual tracking;Work

PROJECT_TITLE: Listening Effort and Gaze Strategies During Audiovisual Speech Perception

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Gaining insight into the molecular basis for the opposing roles that the ERK2-DBP and D domains play in PDAC pathogenesis will enable us to exploit this information to develop new strategies for therapeutic intervention. Moreover, because the RAS/ERK cascade is a critical driver in human PDAC, these findings will have profound implications for the treatment including conceptually innovative ERK2 drug targeting strategies.

PI_NAMEs: ASTSATUROV, IGOR  (contact);WIEST, DAVID L.

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;attenuation;Automobile Driving;Binding;Biological;Blood;cancer therapy;carcinogenesis;cell growth;Cell Line;cell transformation;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;cost;Dependence;Development;Dose Limiting;Drug Targeting;Embryo;Engineering;Epithelial Cells;Exhibits;Fibroblasts;Future;Genes;Genetic Crosses;Genetic Engineering;Genetic Models;Genetic study;Human;in vitro Model;inhibitor;innovation;insight;Intervention;kinase inhibitor;Knock-in;Knock-in Mouse;Knowledge;KPC model;KRAS oncogenesis;KRAS2 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;MAPK1 gene;MAPK3 gene;Mediating;Mitogens;Modeling;Molecular;mouse model;Mus;mutant;mutant mouse model;Mutation;Myeloproliferative disease;novel therapeutic intervention;Oncogenes;Oncogenic;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic tumorigenesis;paralogous gene;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphotransferases;Play;Proliferating;Proteomics;RAS driven cancer;RNA Interference;Role;senescence;Signal Pathway;Signal Transduction;Solid;Substrate Interaction;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tool;Toxic effect;transcriptome;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Divergent Functions of ERK2 Substrate Binding Domains in Pathogenesis of KRAS-Driven Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This proposal will investigate 7 promising neurotrauma biomarkers to be practically adopted for use in multi- institutional clinical studies in acute and subacute TBI, with rapid, reliable results. The goal of this study is to develop reference materials which will allow laboratories the ability to report consistent biomarker results with age-specific reference intervals throughout the lifespan that will allow discrimination from normal values. Finally, we propose to develop preliminary information on how biomarker levels are affected by injury severity, whether they can be used to monitor incipient secondary injury, and whether they have promise as prognostic biomarkers of persistent post-concussive symptoms.

PI_NAMEs: DIAZ-ARRASTIA, RAMON ;HUTCHISON, JAMIE SANDERS;MONDELLO, STEFANIA ;PUCCIO, AVA M. (contact);WANG, KEVIN KA WANG;WELLINGTON, CHERYL LEA

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: Acute;Adopted;Adoption;Adult;Affect;Age;age related;analytical method;Antigens;Astrocytes;astrogliosis;axon injury;Biochemistry;Biological;Biological Assay;Biological Markers;biomarker development;biomarker selection;biomarker validation;Blood;Blood Proteins;Blood specimen;Brain;Calibration;candidate marker;Cause of Death;Child;Clinical;clinical practice;Clinical Research;Clinical Trials;Data;Development;Diagnosis;disability;Discrimination;Disease;drug development;early detection biomarkers;Emergency Care;Emergency Medicine;European;Evolution;experience;Future;Glial Fibrillary Acidic Protein;Goals;Home;Hospitalization;Hospitals;improved;improved outcome;Injury;Institution;Intensive Care Units;International;Intracranial Hypertension;Intracranial Pressure;Laboratories;life span;Light;Mass Spectrum Analysis;Measures;mild traumatic brain injury;Mission;Modeling;Monitor;Multi-Institutional Clinical Trial;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Nervous System Trauma;Neurobiology;neurofilament;neuronal cell body;neuroprotection;Normal Range;Observational Study;Outcome;Pathologic;Patient Admission;Patients;Performance;Persons;Plasma;point of care testing;Population;population based;Post-Concussion Syndrome;pre-clinical research;preclinical study;Procedures;Process;Prognostic Marker;prognostic value;program dissemination;prospective;protein biomarkers;Protein C;Protocols documentation;Qualifying;quality assurance;Quality Control;Recombinant Proteins;Reference Values;Reliability of Results;Reporting;Research;Research Personnel;risk stratification;Role;sample collection;Sample Size;Sampling;Serum;Severities;tau Proteins;tau-1;TBI Patients;TBI treatment;Testing;Time;Transference;Traumatic Brain Injury;ubiquitin C-terminal hydrolase;United States;United States Food and Drug Administration;Validation;Variant

PROJECT_TITLE: Analytical characterization and validation of blood-biomarkers for monitoring TBI evolution

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Rare Diseases

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Esophageal adenocarcinoma is a serious health problem in the United States, with a low survival rate and few treatment options. This proposal will examine how protein adduction by isoLGs affects the cellular and molecular mechanisms to promote cancer, which may lead to the development of novel therapeutic interventions.

PI_NAMEs: CASPA GOKULAN, RAVINDRAN  (contact)

PROJECT_TERMS: Address;adduct;Adult;Affect;Amines;Apoptosis;Atherosclerosis;Barrett Esophagus;Bile Acids and Salts;Bile fluid;Binding;Biological;Biological Models;Biology;Cell Physiology;Cells;Clinical;clinically significant;Data;Defense Mechanisms;Development;Diagnosis;Disease;Disease Progression;DNA Damage;DNA Repair;Duodenum;Epithelial Cells;Epithelium;Esophageal Adenocarcinoma;Esophageal Tissue;Esophagus;Exhibits;Exposure to;Free Radicals;Gastric Acid;Gastroesophageal reflux disease;gastrointestinal;Gene Expression Profile;Genes;Genetic Transcription;Health;Histologic;Human;Hypertension;improved;In Vitro;in vitro Model;in vivo;Inflammation;inhibitor;Injury;innovation;Link;Lipid Peroxidation;Lipids;Lysine;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;Mediating;Modification;Molecular;mouse model;neoplastic;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxidative Stress;Pathogenicity;Pathologic;Patients;pharmacologic;Play;Population;Post-Translational Protein Processing;Precancerous Conditions;Preneoplastic Conditions;prevent;Process;Proliferating;Prostaglandin-Endoperoxide Synthase;Proteins;Reactive Oxygen Species;Reflux;Regulation;Risk Factors;Role;senescence;Signal Pathway;Signal Transduction;stemness;Stomach;Stratified Epithelium;Survival Rate;System;Testing;Therapeutic;Time;tissue injury;Tissues;transcription factor;translational approach;tumor;tumorigenesis;tumorigenic;United States

PROJECT_TITLE: Regulation of esophageal tumorigenesis by protein adduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (O2)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Neurosciences;Pediatric;Rehabilitation

ORG_CITY: LINCOLN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative The proposed project aims to decrease the impact of disability and increase the well-being of children with severe speech and physical impairments (SSPI) for whom conventional forms of verbal communication and access to traditional augmentative and alternative communication (AAC) devices are challenging. Project findings will help mobilize and improve patient-oriented brain-computer interface development for AAC access (BCI-AAC) by pro- moting accelerated training times and supporting inclusive and multimodal AAC access across the lifespan by giving children with SSPI a method of communication, allowing individuals to better communicate with their health providers and more fully participate in medical decision-making. These progressive benefits will help de- crease the risk of preventable adverse medical events and promote children's participation in the worlds of edu- cation, play, and friendship.

PI_NAMEs: PITT, KEVIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Adolescent;Adult;aged;alternative communication;Assessment tool;Attention;Augmentative and Alternative Communication;Brain;brain based;brain computer interface;Caring;Child;Child Support;Child Welfare;Childhood;Clinical;clinical translation;Cognitive;cognitive function;Communication;communication device;Communication Methods;Communication Research;Complex;Decision Making;design;Development;Devices;disability;disability burden;disability impact;Disease;Education;Environment;EP300 gene;Equipment;Event;Event-Related Potentials;Fatigue;Foundations;Friendships;Future;Gestures;Goals;Guidelines;health care availability;Health Care Costs;Health Personnel;Health Professional;Healthcare;Healthcare Systems;Human;Image;implementation framework;improved;Individual;Investigation;Knowledge;Learning;life span;Measures;Medical;Methods;middle childhood;Motion;multidisciplinary;multimodality;National Institute on Deafness and Other Communication Disorders;novel;Outcome;Participant;patient oriented;Patients;Performance;Personal Satisfaction;personalized intervention;Pharmaceutical Preparations;physical impairment;Play;precision medicine;preference;Protocols documentation;Quality of life;Research;research and development;Risk;Scanning;Science;Signal Transduction;social;social engagement;Speech;spelling;success;System;Techniques;Technology;tool development;Training;Translating;usability;verbal;vocalization;Work

PROJECT_TITLE: Foundations of Patient-Oriented AAC Access for Children: Evaluating Picture-Based P300-Brain-Computer Interface Control and Design Preferences


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The National Plan to Address Alzheimer’s disease has identified education of dementia care providers as a top priority to address the need for quality care for the population of persons with dementia that will triple in the next 30 years. This study will adapt and test online interactive training for nursing home staff that improves staff communication and reduces behavioral symptoms of persons with dementia that they care for. This research will adapt and test communication training to meet the needs of nursing homes that serve high proportions of residents of diverse races and ethnicities, to improve care and overcome dementia care health disparities.

PI_NAMEs: WILLIAMS, KRISTINE N. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Administrator;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;Bathing;Behavioral;behavioral response;Behavioral Symptoms;Black American;Black race;care providers;Caring;Clinical Trials;Cluster randomized trial;Communication;Communities;Computerized Medical Record;Consultations;Control Groups;cultural competence;culturally appropriate intervention;Data;Data Set;Dementia;dementia care;Dependence;Diagnosis;Disparity;Education;Educational Intervention;Enrollment;Equity;Ethnic Origin;ethnoracial;Evaluation;evidence base;experience;feasibility testing;Focus Groups;Genetic Transcription;Goals;health care disparity;health disparity;Hispanic;Hispanic Americans;Home Nursing Care;Honey;improved;Incentives;Injury;Intention;interest;Intervention;intervention effect;Knowledge;Leadership;learning outcome;Learning Skill;Measures;meetings;Minority;Modeling;Modification;Nonpharmacologic Therapy;Not Hispanic or Latino;Nurse Administrator;Nursing Homes;nursing intervention;Nursing Staff;older adult;Outcome;Persons;Pharmaceutical Preparations;Population;psychological symptom;psychosocial;Quality of Care;racial diversity;Randomized;Reaction;recruit;Reduce health disparities;Research;Research Personnel;Resources;response;skills;Speech;Speech Sound;Stress;success;Tablets;Technology;Testing;Time;Training;Waiting Lists;Withdrawal Symptom

PROJECT_TITLE: Adapting the CHATO Communication Intervention for Diverse Nursing Home Communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-S (O1)]


ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Despite advances in stroke prevention and treatment, stroke continues is a public health priority as a leading cause of death and disability worldwide. Multicenter clinical trials are needed to test new discoveries that may reduce this burden in the treatment, prevention, and recovery arenas. The Ohio Valley RCC proposes continued partnership with the NIH Stroke NET to improve clinical trial efficiency, success, and quality, and thereby advance stroke care.

PI_NAMEs: DEMEL, STACIE ;MISTRY, EVA  (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, SEAN PATRICK

PROJECT_TERMS: Acute;Adult;Agreement;Applications Grants;Award;Brain hemorrhage;Budgets;career;career development;Caring;Cause of Death;Child;Childhood;Clinical;Clinical Research;Clinical Trials;Communication;community setting;comparative effectiveness study;data management;data quality;disability;Discipline of Nursing;Emergency Medicine;Enrollment;Environment;Epidemiology;experience;Faculty;Fellowship;Fibrinolytic Agents;Fostering;Foundations;Funding;Goals;Grant;Hospitals;improved;Industry;informal learning;innovation;Institution;International;Ischemic Stroke;Job Satisfaction;Leadership;Mission;Modeling;Multi-Institutional Clinical Trial;multidisciplinary;Names;National Institute of Neurological Disorders and Stroke;neuroimaging;Neurology;neurosurgery;next generation;novel;Observational Study;Ohio;operation;Participant;participant retention;patient population;Patients;Pediatric Hospitals;performance site;Pharmacy facility;phase II trial;Prevention;Privatization;Productivity;programs;public health priorities;racial minority;Recovery;recruit;Rehabilitation therapy;Research;Research Infrastructure;Research Personnel;Role;Satellite Hospitals;Scientist;Secondary Prevention;Secondary to;Site;Specialist;Stroke;stroke intervention;stroke neurology;Stroke prevention;stroke therapy;stroke trials;success;Testing;Time;Training;Training and Education;Training Programs;treatment trial;trial design;United States National Institutes of Health;Universities;Wages;Work;working group

PROJECT_TITLE: Ohio Valley Regional Coordinating Center for NINDS Stroke Trial Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (17)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lymphatic Research;Lymphoma;Patient Safety;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE It is not known whether it is feasible to perform circulating tumor DNA (ctDNA) sequencing in real-time to guide treatment decisions during therapy for newly diagnosed diffuse large B-cell lymphoma. Patients who achieve an excellent interim ctDNA-defined response during frontline treatment experience high cure rates and can likely receive an abbreviated chemotherapy course with decreased toxicity and without compromising outcomes. This response-adapted approach, if feasible, can subsequently evaluated in a larger randomized study, as well as applied to escalation strategies for patients with suboptimal interim ctDNA-defined response.

PI_NAMEs: CHERNG, HUA-JAY JEFFERY (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Abbreviations;Adopted;Adult;Adverse event;BCL2 gene;BCL6 gene;Biological Assay;Calibration;chemotherapy;Clinical;clinical practice;Cyclophosphamide;Decision Making;Detection;detection assay;detection limit;Detection of Minimal Residual Disease;Disease remission;DNA sequencing;Doxorubicin;Early treatment;Eligibility Determination;Enrollment;experience;Failure;flyer;follow-up;Future;high risk;Hybrids;improved;large cell Diffuse non-Hodgkin's lymphoma;Lead;Limited Stage;liquid biopsy;Malignant Neoplasms;Minority;Molecular;Mutation;Newly Diagnosed;next generation sequencing;novel;Outcome;overtreatment;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;peripheral blood;Phase;Pilot Projects;Prednisone;Progression-Free Survivals;prospective;Protocols documentation;Quality of life;Randomized;Regimen;Residual Neoplasm;response;Risk;Risk Assessment;rituximab;Safety;Sampling;Series;Somatic Mutation;Techniques;Technology;Testing;Time;Toxic effect;treatment risk;treatment strategy;tumor;tumor DNA;Variant;Vincristine

PROJECT_TITLE: Circulating tumor DNA guided de-escalation of frontline diffuse large B-cell lymphoma therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (O1)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Multispectral optoacoustic tomography (MSOT) is a non-invasive newly emerging imaging technology that potential for detecting inflammation. MSOT can identify areas of inflammation, but additional molecular information is often required, particularly in areas of chronic inflammation, which can be enhanced by probiotic bacterial-based contrast agent.

PI_NAMEs: GOMEZ-GUTIERREZ, JORGE G (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acidosis;Acids;Acute;Anesthesia procedures;Antibodies;Antigens;Area;Arthritis;Autoimmune Diseases;Automobile Driving;Bacteria;beta-Galactosidase;Biological;biomaterial compatibility;Biomedical Engineering;blood-based biomarker;chemical synthesis;Chronic;chronic inflammatory disease;Clinical;Colitis;Colon;Colonoscopy;Color;Contrast Media;cost;cytokine;Data;deoxyhemoglobin;Detection;Development;Disease;disease diagnosis;Dyes;Early identification;Engineering;Enzymes;Etiology;Exposure to;Flare;Functional disorder;Goals;Growth;gut bacteria;gut inflammation;Heat Stress;Hemoglobin;Hepatitis;Homing;Hyperthermia;Hypoxia;Image;imaging modality;Imaging technology;improved;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injections;innovation;Label;lactic acid bacteria;Lactococcus lactis;LCN2 gene;Methods;Modality;Modeling;Molecular;molecular imaging;Monitor;Motility;mouse model;Mucous Membrane;murine colitis;Mus;nanomaterials;non-invasive imaging;optoacoustic tomography;Organism;Pathology;Peptides;Perforation;preclinical trial;Probiotics;Procedures;Production;promoter;Radiation;Recombinant Proteins;Reporter;Resolution;Risk;Safety;Sedation procedure;Signal Transduction;spatiotemporal;Specificity;Stimulus;Surface;System;Technology;Testing;Tissues;Toxic effect;treatment response;tumor hypoxia;ultrasound;Zinc

PROJECT_TITLE: Bioengineering probiotic bacterium contrast agents for monitoring of inflammation using multispectral optoacoustic tomography

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-G (O1)]


NIH_SPENDING_CATS: Cancer;Lung;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE Osteosarcoma (OS) is the most common bone tumor in pediatric patients, and the survival rates for patients with lung metastatic OS (pOS) have remained poor for more than 3 decades despite encouraging progress in the management of non-metastatic primary OS. For this reason, novel and directed therapy approaches that target pOS are desperately needed. It has been shown that TGF-β production is increased in the sera of OS patients and this increase in TGF-β production is correlated with high grade OS and associated with the presence of lung metastases, suggesting that targeting TGF-β signaling may be a novel therapeutic approach for pOS. This proposal seeks to establish an orally available small molecule inhibitor of TGF-β Type 1 Receptor as a novel therapy for pOS.

PI_NAMEs: CHOI, SUNG HEE  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Adjuvant Chemotherapy;Adolescent and Young Adult;Adoptive Transfer;Advocate;Affect;Age;Asia;Authorization documentation;Bone neoplasms;c-myc Genes;Cancer Center;Cell Cycle Progression;Cell Line;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Clinical;clinical prognosis;clinical translation;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Diagnosis;Disease;Disease-Free Survival;Europe;Excision;Future;Goals;Growth;Human;humanized mouse;Immune;immune activation;Immune response;Impairment;improved;In Vitro;in vitro Model;in vivo;inhibitor;Kinetics;Literature;lung metastatic;Malignant - descriptor;Metabolism;Metastatic Neoplasm to the Lung;Metastatic Osteosarcoma;Mitotic Cell Cycle;mouse model;Multiple Myeloma;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;Neoplasm Metastasis;Nonmetastatic;novel;novel marker;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oral;Oral Administration;Orphan Drugs;Osteosarcoma;Outcome;overexpression;patient derived xenograft model;Patients;pediatric patients;Phase I Clinical Trials;Phase I/II Clinical Trial;Phosphotransferases;pre-clinical;primary bone cancer;Production;Proliferating;Proto-Oncogenes;receptor;recruit;Refractory;Regulation;Regulatory T-Lymphocyte;Research;response;Role;Scheme;side effect;Signal Transduction;Site;small molecule inhibitor;Solid Neoplasm;Survival Rate;Testing;TGF-beta type I receptor;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Transforming Growth Factor beta;translational potential;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue

PROJECT_TITLE: c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (O2)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Lung;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Middle-aged and older people with schizophrenia have high rates of cognitive impairment and associated disability, however there is a lack of effective interventions. Obstructive sleep apnea may be a potentially treatable contributor to cognitive problems in people with schizophrenia. This project proposes to lay the groundwork for future intervention trials by clarifying the impact of sleep apnea on cognition, examining the role of inflammation as a surrogate biomarker, and identifying key risk factors that contribute to cognition in this high-risk and understudied group.

PI_NAMEs: LEE, ELLEN EUN-OK (contact)

PROGRAM_OFFICER_NAME: ROWLAND, LAURA

PROJECT_TERMS: Address;Affect;Age;Aging;aging population;Antipsychotic Agents;Behavior;Bioinformatics;Biological;Biological Markers;Biometry;Brain;career;Case/Control Studies;Cells;Cognition;Cognitive;Cognitive deficits;cognitive disability;cognitive function;cognitive reserve;cognitive testing;comorbidity;comparison group;Complex;Data;Dementia;design;Deterioration;Development;Diagnosis;disability;Disease;Doctor of Philosophy;Ecological momentary assessment;effective intervention;effective therapy;Event;Executive Dysfunction;executive function;experience;Foundations;functional decline;Future;Gene Expression;General Population;Genomics;Goals;high risk;high risk population;human old age (65+);Hypoxia;Immune;Impaired cognition;improved;Inflammation;Inflammatory;innovation;Interferon Type II;Intervention;Intervention Trial;Investigation;lifestyle intervention;Link;male;middle age;modifiable risk;molecular marker;National Institute of Mental Health;Neurocognitive;Neuropsychology;novel;Obesity;Obstructive Sleep Apnea;Older Population;Onset of illness;Outcome;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Physiology;positive airway pressure;prevent;promoter;Psychoneuroimmunology;Questionnaires;Reporting;Research;Research Personnel;Restless Legs Syndrome;Risk;Risk Factors;Role;Schizophrenia;sedentary lifestyle;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;Sleeplessness;Smoking;stem;Strategic Planning;Surrogate Markers;Symptoms;targeted treatment;transcription factor;treatment trial;Vulnerable Populations;Work

PROJECT_TITLE: Cognitive Consequences of Obstructive Sleep Apnea in Schizophrenia: An Investigation of Inflammatory Mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (06)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MATHER

ORG_NAME: VA NORTHERN CALIFORNIA HEALTH CARE SYS

PHR: PARP inhibition (PARPi) including Olaparib is a novel strategy for the treatment of advanced prostate cancer approved in 2020. Despite this tremendous step forward, resistance to PARPi has already been clinically documented. Very little is known regarding the mechanisms of resistance development. This proposal will study novel models of PARPi resistance which will allow us to characterize mechanisms mediating PARPi sensitivity. This study will define the role of IGFBP3 as a key mediator of resistance, and explore novel therapeutic strategies which may be developed for clinical impact.

PI_NAMEs: GAO, ALLEN C. (contact)

PROJECT_TERMS: advanced prostate cancer;antitumor effect;Antitumor Response;Apoptosis;Cell Culture Techniques;Cell Death;Cell Fractionation;Cell Line;Cell Survival;Cells;Clinical;Complex;Data;Defect;Disease;DNA Damage;DNA Repair;DNA Repair Pathway;DNA-dependent protein kinase;DNA-PKcs;EGFR inhibition;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;experimental study;Gefitinib;IGFBP3 gene;In Vitro;in vivo;inducible gene expression;inhibitor;LNCaP;Measures;Mediating;Mediator;Modeling;Monitor;mortality;Nature;neoplastic cell;Nonhomologous DNA End Joining;novel;novel strategies;novel therapeutic intervention;Nuclear;Oral;overexpression;PARP inhibition;pharmacologic;Phosphorylation;pre-clinical;precision medicine;Proliferating;prostate cancer cell line;Prostate Cancer therapy;Publishing;Research;Resistance;Resistance development;resistance mechanism;RNA Interference;Role;senescence;Signal Pathway;Small Interfering RNA;small molecule inhibitor;Stress;System;Testing;TP53 gene;transcriptome sequencing;translational potential;treatment strategy;tumor;tumor growth;tumor xenograft;Work

PROJECT_TITLE: Novel roles of IGFBP3 in Olaparib resistance in advanced prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ONCA-S (01)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Endocrine Disruptors;Health Effects of Indoor Air Pollution;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

PHR: Project Narrative Anthropogenic chemicals are likely contributing to rising rates of neurodevelopmental disorders (NDDs) with socioemotional deficits, but the vast majority of work on NDDs to date has focused on genetic rather than environmental risk factors. Here we employ an animal model of social behavior, the prairie vole, to investigate how developmental exposure to a widespread environmental chemical contaminate impacts areas of the nervous system relevant to two behavioral traits common to many NDDs: anxiety and sociality. To achieve this goal, we focus on a widely-used flame retardant mixture implicated in human and animal studies known to contribute to a wide variety of sex-specific adverse effects on socioemotional related behaviors.

PI_NAMEs: MEITZEN, JOHN  (contact)

PROJECT_TERMS: Address;Adverse effects;Animal Model;Animals;anthropogenesis;Anxiety;Architecture;Area;Autoradiography;awake;Behavior;Behavioral;behavioral impairment;Brain;Brain region;Caring;Cells;Chemical Exposure;Chemicals;density;Development;Disease;disorder risk;Dopamine;Dose;Electronics;Electrophysiology (science);Emotional;environmental chemical;environmental chemical exposure;Environmental Pollutants;Environmental Risk Factor;exposed human population;Exposure to;Female;Flame Retardants;Furniture;Gene Expression;generalized anxiety;Genetic;Goals;Human;human model;Impaired cognition;Infant;innovation;insight;interdisciplinary approach;interest;Laboratories;Link;male;Maps;Measures;Microtus;Modeling;Motivation;Mus;National Institute of Mental Health;Nervous System;neural;neural network;neurochemistry;Neurodevelopmental Disorder;neurodevelopmental effect;neuromechanism;Neuromodulator;Neurons;Neurosecretory Systems;neurotoxicology;novel;Nucleus Accumbens;Oxytocin;Pair Bond;patch clamp;Periodicity;prairie vole;Rattus;receptor;receptor density;receptor expression;Receptor Gene;Research;Risk;Rodent;Role;Scanning;sex;Sex Differentiation;Signal Transduction;social;social anxiety;Social Anxiety Disorder;social attachment;Social Behavior;Social Interaction;Structure;System;Techniques;Testing;tool;Toxicology;trait;transcriptomics;Vasopressins;Weight;Woman;Work

PROJECT_TITLE: Neurodevelopmental effects of flame retardant exposure


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE TNBC is heavily reliant on the autophagy program for survival. We have discovered that ULK3, a key regulator of autophagy initiation, is highly expressed in TNBC and genetic or pharmacological inhibition of this kinase causes autophagy cessation and compromises TNBC viability. For the first time, we have generated a highly selective ULK3 inhibitor and in the proposed studies herein, we will evaluate the efficacy of the molecule in vitro and in vivo, in addition to performing deeper analyses on the expression of ULK3 in human specimens of the disease.

PI_NAMEs: TAURO, MARILENA  (contact)

PROJECT_TERMS: 4T1;Ablation;aggressive breast cancer;Amino Acids;Automobile Driving;Autophagocytosis;Biological Assay;Biological Markers;Bioluminescence;Biopsy;bone;Brain;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer care;cancer subtypes;capecitabine;CASP3 gene;cell immortalization;Cell Line;Cell Survival;Cells;Cellular Stress;Characteristics;chemotherapy;Chloroquine;Cisplatin;Clinical;Clinical Treatment;Clinical Trials;clinically significant;cohort;Data;Data Set;design;Diagnosis;Disease;Doxorubicin;Drug Exposure;effective therapy;efficacy evaluation;ERBB2 gene;ESR1 gene;Estrogen Receptor 2;Estrogen receptor positive;experimental study;Exposure to;Flow Cytometry;Funding Opportunities;Future;gemcitabine;Gene Expression;Genetic;genetic analysis;Goals;Growth;Hand;Hormonal;Human;Immunoblot Analysis;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vivo;in vivo evaluation;inhibition of autophagy;inhibitor;insight;Institutional Review Boards;Kidney;kinase inhibitor;Lead;Liver;Luciferases;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;MDA MB 231;Measures;Medicine;Metabolic;Metastatic Neoplasm to the Lung;Methodology;Modeling;Molecular;Mus;Neoplasm Metastasis;new therapeutic target;Normal tissue morphology;novel;Operative Surgical Procedures;patient biomarkers;patient population;Patient Selection;Patients;Peripheral;pharmacologic;Phosphotransferases;pre-clinical;Process;Prognosis;prognosis biomarker;programs;Protein Tyrosine Kinase;Proteins;Randomized;Reagent;receptor;Relapse;Research Project Grants;Resistance;response;Retrospective Studies;Sampling;Specimen;Spleen;standard of care;Starvation;SUM-159 Breast Cancer Cell Line;Supporting Cell;synergism;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Tissue Microarray;Tissues;Toxic effect;Translating;Treatment Effectiveness;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;Vesicle;Work

PROJECT_TITLE: Targeting ULK3 for the treatment of triple negative breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (O1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE In elderly people, an episode of psychosis characterized by the development of delusions or hallucinations increases the risk of subsequently developing dementia; the biologic mechanism(s) responsible for this increased risk are poorly understood. Tau proteins in the brain, known to increase the risk of Alzheimer’s disease psychosis, may be responsible for the increased risk of dementia in people who become psychotic. The current application will use novel brain imaging and peripheral blood tests to measure tau proteins in elderly people who have become psychotic to determine whether tau may be a risk factor.

PI_NAMEs: KOPPEL, JEREMY  (contact)

PROJECT_TERMS: Acoustics;Acute;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease risk;Antipsychotic Agents;Appearance;Autopsy;Biological;Biological Assay;Biological Markers;Blood Tests;Brain;Brain imaging;Cerebrospinal Fluid;Cognitive;cohort;Data;Delusional disorder;Delusions;Dementia;dementia risk;Detection;Development;Disease;early onset;Elderly;Etiology;experience;Funding;Hallucinations;Health;Immunoassay;Impaired cognition;Impairment;Intervention;Life;Ligands;Liquid substance;Measures;Medical;Mental disorders;mood symptom;mortality risk;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroimaging;non-affective psychoses;novel;Outcome;Outcome Assessment;Pathology;Patients;Peripheral;peripheral blood;Persons;Pharmaceutical Preparations;Pilot Projects;Plasma;Positron-Emission Tomography;Pre-Clinical Model;prepulse inhibition;Process;Psychoses;psychotic;Psychotic Disorders;psychotic symptoms;Risk;Risk Factors;Scanning;Schizophrenia;single molecule;tau Proteins;Testing;Time;Visualization

PROJECT_TITLE: Tau biomarkers in late-onset psychosis


NIH_SPENDING_CATS: Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rehabilitation;Stroke

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Auditory comprehension deficits are pervasive in stroke-induced aphasia, yet there are few tools that can be used to precisely identify the source of these deficits within the speech and language system. The proposed study has the potential to improve characterization of auditory comprehension in aphasia by examining the validity and test-retest reliability of an objective tool, temporal response function (TRF) modeling. Establishing the validity of TRF-derived measures will build confidence in their ability to assess auditory comprehension, whereas knowledge of normal variability across sessions for TRF-derived measures will help researchers to make informed inferences about treatment-related outcomes or spontaneous recovery so that test-retest variability is not mistakenly taken to reflect meaningful change.

PI_NAMEs: DIAL, HEATHER  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;Address;Age;Aphasia;auditory comprehension;chronic stroke;Clinical;Cognitive;Communication;comprehension deficit;Control Groups;Cues;Data;design;Development;Dimensions;Education;Electroencephalography;Frequencies;Hearing;improved;Individual;Intervention;Knowledge;Language;Language Disorders;lexical;Linguistics;Maps;Measures;Modeling;neural;neural correlate;older adult;Outcome;Participant;Performance;Population;Primary Progressive Aphasia;Principal Component Analysis;Process;Quality of life;Recovery;recruit;Research Personnel;Resources;response;Semantics;Source;Speech;Standardization;Stimulus;stroke-induced aphasia;syntax;System;Testing;tool;Validity and Reliability;Work;young adult

PROJECT_TITLE: Reliability and validity of temporal response function modeling in aphasia


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: MIDDLEBURY

ORG_NAME: MIDDLEBURY COLLEGE

PHR: PROJECT NARATIVE Testosterone levels decline steadily with increasing age in men, and this change has been implicated as a risk factor for age-related memory loss in general and for Alzheimer’s disease in particular among older men. The proposed experiments will test the potential cognitive benefits of testosterone treatments using castrated male rats to model the dose-dependent effects of testosterone on learning and memory. To determine the physiological mechanisms by which testosterone influences the aged brain, male rats from three age classes (young, middle-aged, and old) will be tested on specialized maze tasks, their brain protein levels will be assayed, and neural connections among brain regions will be assessed using electrophysiology.

PI_NAMEs: SPRITZER, MARK D. (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Affect;Age;age effect;age group;age related;age related decline;age-related disease;aged;Aging;aging brain;aging population;Alzheimer's Disease;Androgen Therapy;Androgens;Animal Model;antagonist;behavior change;Behavioral;Biological Assay;Brain;Brain region;Brain-Derived Neurotrophic Factor;Castration;Clinical Trials;cognitive ability;cognitive benefits;Complex;Corpus striatum structure;DLG4 gene;Dose;Electrophysiology (science);experimental study;Frequencies;Hippocampus;Human;human old age (65+);Hypogonadism;Impaired cognition;Impairment;improved;Incidence;Injections;Learning;Link;male;Male Castration;Mediating;Memory;Memory impairment;Memory Loss;men;middle age;Modeling;Molecular;neural;Neuronal Plasticity;Neurons;older men;Older Population;Phase;Physiological;Play;Process;Proteins;Rattus;Replacement Therapy;response;Risk Factors;Rodent;Role;Serum;Short-Term Memory;Signaling Molecule;spatial memory;System;Testing;Testosterone;Therapeutic;therapeutic evaluation;Tissues;Work

PROJECT_TITLE: Determining the roles of brain-derived neurotrophic factor (BDNF) and neuronal synchrony in the memory-enhancing effects of testosterone in the aging male brain.

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Endocrine Disruptors;Estrogen;Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Early puberty in girls is one of the strongest predictors of depression in early adulthood. These studies will examine how exposure to an endocrine disrupting compound, which accelerates the onset of puberty, can alter a brain system important for mood. These studies will directly inform the development of novel strategies to improve mental health outcomes in young women.

PI_NAMEs: JAMES, MORGAN H. (contact);ROEPKE, TROY ADAM

PROJECT_TERMS: Acceleration;Adolescence;Affect;Age;Anhedonia;Attention;Behavior;behavioral outcome;Binding;bisphenol A;Brain;Cells;child depression;conditioning;consumer product;Cues;Data;density;Development;Dose;Electrophysiology (science);emerging adult;Endocrine Disruptors;Endogenous Factors;environmental chemical exposure;Environmental Exposure;Environmental Impact;Estradiol;Estrogen Receptors;estrogenic;Estrogens;Estrus;Etiology;Exhibits;experimental study;Exposure to;Female;Fiber;Food;Genetic;genetic approach;girls;Goals;Hormonal;hypocretin;Hypothalamic structure;Impairment;improved;Label;Laboratories;Link;Major Depressive Disorder;Measures;Mediating;Mediator;Menarche;Mental Depression;Mental disorders;Mental Health;Messenger RNA;Modeling;Moods;motivated behavior;Motivation;National Institute of Environmental Health Sciences;Neurobiology;Neurons;Neuropeptides;novel;novel strategies;Outcome;Peptides;peripubertal period;Phenotype;Photometry;Pilot Projects;Proteins;pubertal timing;Puberty;Rat Transgene;Rattus;response;Rewards;Risk;Rodent;Role;sensor;Series;Signal Transduction;Site;Stimulus;Sucrose;Symptoms;System;targeted treatment;Testing;Translating;Ventral Tegmental Area;women's outcomes;young woman

PROJECT_TITLE: The orexin system as a novel mediator of depression-like outcomes in female rats exposed to an endocrine disrupting compound during the peripubertal period

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 VSM-S (PD)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Project Narrative Listeria monocytogenes is the causative agent of listeriosis, a potentially fatal foodborne infection that can affect humans and animals. To survive in host cells and establish infection, L. monocytogenes must be able to withstand oxidative damage caused by reactive oxygen species generated by host oxidative burst. This proposal investigates how L. monocytogenes adapts its metabolic pathways to combat oxidative stress to enable future development of better treatment options.

PI_NAMEs: ABDELHAMED, HOSSAM A (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Ampicillin;Animals;Antibiotic Therapy;antioxidant enzyme;Antioxidants;Attenuated;Bacteria;biological adaptation to stress;Carbon;Cells;combat;Death Rate;Development;DNA Repair;Drug Metabolic Detoxication;Electrophoretic Mobility Shift Assay;Environment;enzyme pathway;Enzymes;Equilibrium;Escherichia coli;Eukaryotic Cell;Exposure to;Family;foodborne infection;Future;Gene Expression;Genes;Genetic Transcription;Glucose;glutaredoxin;Glutathione;Glycolysis;Goals;Green Fluorescent Proteins;Homeostasis;Host Defense;Host Defense Mechanism;Human;human pathogen;Infection;innovation;inorganic phosphate;Knowledge;Label;Listeria monocytogenes;Listeriosis;Mammalian Cell;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mus;NADP;novel;novel therapeutics;Nutrient;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Penicillins;Pentosephosphate Pathway;peroxiredoxin;Phagocytes;Phagosomes;preservation;Production;promoter;Proteins;Reactive Oxygen Species;Regulation;Reporter;Reporting;Resistance;Respiratory Burst;response;Ribose;Role;Route;Stress;System;Systemic infection;Testing;Therapeutic Agents;Toxic effect;transcriptome sequencing;TXN gene;Up-Regulation;Virulence;Yeasts

PROJECT_TITLE: Metabolic changes that promote adaptation of Listeria monocytogenes to oxidative stress and preserving intracellular redox homeostasis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Public Health Relevance The aims of the project are to give us mechanistic, biological insights into how attention to object features and locations regulates the processing of incoming visual information. These new insights will aid in the development of a neuro-prothesis for blindness and will also help us develop new treatments for people suffering sensory and attentional impairments.

PI_NAMEs: DESIMONE, ROBERT  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Anatomy;Animals;Area;area V4;Attention;attentional control;attentional modulation;Biological;Blindness;Brain;Cells;Communities;Complex;connectome;Coupled;Data;design;Development;Dissociation;Dorsal;Electric Stimulation;electrical microstimulation;Etiology;extrastriate visual cortex;Eye;Eye Movements;Feedback;frontal eye fields;Functional Magnetic Resonance Imaging;gaze;Impairment;Inferior;Injections;innovation;insight;Lateral;lateral intraparietal area;Location;Maps;Mediating;Methods;Muscimol;neural;neural prosthesis;neuromechanism;Neurons;neurophysiology;Neurosciences;Occipital lobe;optogenetics;Persons;Play;Population;Positioning Attribute;Prefrontal Cortex;Primates;Process;Property;public health relevance;Publishing;Pulvinar structure;Resources;response;Role;Sensory;Site;Specificity;Structure;Structure of superior temporal sulcus;Surface;System;Techniques;Technology;Temporal Lobe;Testing;Visual attention;visual control;Visual Cortex;visual information;visual processing;visual search;Work

PROJECT_TITLE: Neural Mechanisms for Feature-Based Attention

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_DEPT: GENETICS

PHR: Colorectal cancer is the second most common cause of cancer deaths in the United States, with 150,000 new cases and 55,000 deaths per year. Our proposed studies will provide novel understanding to how cancer cells become dependent on an amino acid called glutamine. Most importantly, we will investigate whether deprivation of glutamine in cancer cells by a drug will starve cancer cells to death, thereby providing a novel therapy to treat colorectal cancer patients.

PI_NAMEs: WANG, ZHENGHE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Aftercare;Amino Acids;anti-cancer research;Apoptosis;Attenuated;Bacteria;Binding;Biopsy;cancer cell;Cancer Etiology;Cancer Model;capecitabine;Cathepsin G;Cell Surface Proteins;Cessation of life;chemokine;Chromatin;Clinical;Clinical Trials;colon cancer patients;Colon Carcinoma;Colorectal Cancer;Communication;Cytoplasmic Granules;Data;Deoxyribonuclease I;deprivation;Disease;Drug Combinations;drug efficacy;extracellular;Fluorouracil;Funding;fungus;Genetically Engineered Mouse;Glutaminase;Glutamine;Goals;Growth;Heterogeneity;Human;IL8 gene;Immune system;Immunocompetent;inhibitor;innovation;Internet;Journals;Knock-in;Malignant Neoplasms;Metabolic;metastatic colorectal;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Nature;Neoplasm Metastasis;neutrophil;novel;novel therapeutics;Nude Mice;Oncogenic;Oral;Outcome;Parasites;partial response;patient derived xenograft model;Patients;Peer Review;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase II Clinical Trials;PIK3CA gene;Prodrugs;Progression-Free Survivals;Proteins;Publications;Reactive Oxygen Species;recruit;Refractory;Reporting;Research;Research Personnel;Serine Protease;Stable Disease;Starvation;Structure;Testing;Translating;tumor;tumor xenograft;United States;Virus;Xenograft procedure

PROJECT_TITLE: Mechanisms of metabolic reprogramming by PIK3CA oncogenic mutations

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Brain Disorders;Dietary Supplements;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: HONOLULU

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Oxidative stress is a known contributing factor to the pathogenesis of mental illness. Mercury is a neurotoxin that promotes oxidative stress by binding to selenium moieties present in antioxidant selenoenzymes, thereby disrupting their function. The objective of this proposal is to better comprehend how interactions between mercury and selenium during adolescence influence redox signaling and subsequent risk of psychiatric disorders.

PI_NAMEs: PITTS, MATTHEW WILLIAM (contact)

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Affinity;Antioxidants;Behavior;Behavioral;behavioral phenotyping;Binding;Biological Assay;Biological Markers;Blood;Brain;brain tissue;cell type;Chemicals;Chronic;Clinical;Cognition;critical period;Development;Dietary Selenium;Dose;Electrodes;Electrophysiology (science);emerging adult;Equilibrium;experimental study;Exposure to;extracellular;glutathione peroxidase;Goals;gut microbiota;Homeostasis;Impairment;In Vitro;indexing;innovation;Interneurons;Joints;Knowledge;Long-Term Effects;Mediating;Mental disorders;Mercury;Metabolism;Methylmercury Compounds;Minamata Disease;mitochondrial dysfunction;modifiable risk;Molecular;Mus;neural circuit;Neurobiology;neurodevelopment;Neurons;Neurotoxins;neurotransmission;Outcome Study;Oxidation-Reduction;Oxidative Stress;Parvalbumins;Pathogenesis;postnatal;Process;Public Health;Reporter;Research;Risk;Risk Factors;risk minimization;Rodent;Role;Selenium;selenoenzyme;selenoprotein;Signal Transduction;Sulfur;Symptoms;Syndrome;System;Time;tool;Toxicant exposure;transcriptomics;Visualization;World Health Organization

PROJECT_TITLE: Assessment of the joint influence of methylmercury and selenium upon postnatal brain development and risk for psychiatric disorders


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE T-cell large granular lymphocytic leukemia (T-LGLL) is an incurable leukemia that results in frequent infections, transfusions, and death with no FDA-approved therapies and few marginally effective treatment options. T-LGLL is caused by an inflammatory growth factor, interleukin-15 (IL-15), that was recently targeted in a clinical trial with an IL-15 blocking drug (BNZ-1) with some efficacy, though laboratory studies demonstrated that leukemia cell populations became resistant to BNZ-1 by gene changes that disable anti-self-destruct (apoptotic) genes. This proposal seeks to use cutting-edge genomic techniques that enable the identification of gene changes in every single leukemia cell, to test the hypothesis that decrease in apoptotic gene pathways in populations of T- LGLL lead to resistance to treatment with BNZ-1; thereby providing targets for future novel drug trials for T-LGLL.

PI_NAMEs: BRAMMER, JONATHAN EDWARD (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Address;Adverse drug effect;Anemia;Antigens;Apoptosis;Apoptotic;Autoimmune Diseases;Blood;CD8B1 gene;Cell Death;Cell Death Induction;Cells;Cessation of life;Chronic;chronic T-cell leukemia;Clinical;clinical remission;Clinical Trials;Clonal Expansion;cohort;combinatorial;cytokine;cytopenia;cytotoxic CD8 T cells;Data;Dependence;deprivation;Development;Diagnosis;Disease;Dose;effective therapy;FDA approved;Flow Cytometry;follow-up;Future;Gene Expression;Gene Expression Profile;Gene Targeting;Genes;Genomics;Growth Factor;Hour;Immune;Immunosuppressive Agents;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammatory;Infusion procedures;insight;Interleukin-15;Intervention Trial;Investigation;Laboratories;Laboratory Study;Lead;leukemia;Leukemic Cell;leukemic transformation;Mediating;Multicenter Trials;Neutropenia;NF-kappa B;novel;novel therapeutics;Pathogenesis;Pathogenicity;Pathway Analysis;Pathway interactions;Patient Selection;Patients;Peptides;Pharmaceutical Preparations;Phase I/II Clinical Trial;PIK3CG gene;Population;Proliferating;recurrent infection;Reporting;Resistance;resistance mechanism;responders and non-responders;response;Risk;Sampling;Secondary to;Signal Pathway;single cell sequencing;single-cell RNA sequencing;Specimen;STAT3 gene;T cell receptor repertoire sequencing;T memory cell;T-Cell Large Granular Lymphocyte;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;therapeutic evaluation;therapeutic target;Time;Tissue-Specific Gene Expression;transcriptomics;Transfusion;translational impact;Tumor Necrosis Factor Ligand Superfamily Member 6;Up-Regulation;Validation

PROJECT_TITLE: Mechanisms of Resistance and Therapeutic Targets in T-LGL Leukemia


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Symptoms of idiopathic hypersomnia are debilitating and pose safety concerns and thus, there is a critical need to improve diagnostic accuracy. Using sleep neurophysiological biomarkers to diagnose this neurological disease is novel given most clinicians focus on measuring daytime sleepiness to establish diagnosis and treatment efficacy. The idiopathic hypersomnia nocturnal sleep traits we identify will also serve as the foundation for development and testing of therapies that improve sleep pathology and reduce disease burden.

PI_NAMEs: MASKI, KIRAN PRASAD (contact)

PROJECT_TERMS: accurate diagnosis;Adolescence;Adolescent;Beds;Biological Markers;biomarker development;biomarker discovery;biomarker signature;burden of illness;Central Nervous System Diseases;Chemosensitization;Chronic;circadian;Classification;Clinic;Clinical;clinical care;clinical heterogeneity;Clinical Research;clinical trial enrollment;cohort;Data;Data Correlations;Databases;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic criteria;Diagnostic tests;Disabling;Disease;Disorders of Excessive Somnolence;Drowsiness;drug development;effective therapy;Foundations;Functional disorder;Future;GABA Receptor;Grant;heart rate variability;Hour;Hypersomnias;Idiopathic Hypersomnolence;improved;improvement on sleep;International;Judgment;Knowledge;Measures;meetings;Methods;Modeling;multidisciplinary;multimodality;Muscle Tonus;Narcolepsy;Nervous System Disorder;neurophysiology;non rapid eye movement;novel;Obstructive Sleep Apnea;Occupational;Outcome;Pathology;Patients;Performance;Persons;Phase;Population;Process;Prospective Studies;Protocols documentation;Recommendation;Records;Reporting;Research;Resources;Risk;Safety;Sensitivity and Specificity;Severities;Signal Transduction;Site;Sleep;Sleep Disorders;Sleep Stages;Specific qualifier value;Specificity;statistics;success;supervised learning;Surveys;Symptoms;Testing;Therapeutic;Time;trait;Treatment Efficacy;Validation;Validity and Reliability;Work

PROJECT_TITLE: Development and Validation of a Nocturnal Sleep Signature for the Diagnosis of Idiopathic Hypersomnia


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative This project focuses on the fundamental question of how bacteria organize their DNA to maintain cellular health, consistent with the NIGMS mission to support basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. Understanding the sensitivity of the nucleoid dynamics to the number, size, and spatial distribution of chromosome interacting domains is a fundamental question that should also suggest approaches to disrupt that structure, which would have lethal effects on bacteria by impeding protein binding and DNA transcription.

PI_NAMEs: DORFMAN, KEVIN D (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Acceleration;Affect;Bacteria;Bacterial Genome;Basic Science;Behavior;Binding Proteins;Biological;Biological Phenomena;Biological Process;biological systems;Biology;Biophysics;Caulobacter crescentus;Cell division;Cell Line;Cells;Chromatin;Chromosomes;Circular DNA;Communities;Couples;Crowding;Data;Data Set;density;Diffusion;disease diagnosis;DNA;DNA-Binding Proteins;Environment;environmental change;Equilibrium;Escherichia coli;Eukaryota;experimental study;Feedback;Foundations;Frequencies;Frustration;Generations;genetic information;Genetic Transcription;Glass;Grain;gut microbiome;Health;improved;interest;laser tweezer;Laws;live cell imaging;Maintenance;Measures;Metabolic;Metabolism;Microbiology;Microfluidics;Mission;Modeling;Motion;National Institute of General Medical Sciences;Nature;Nuclear Envelope;optic tweezer;Outcome;particle;pathogen;physical model;Physics;Polymers;Prevention;Property;Publishing;response;Sampling;simulation;Solvents;Spatial Distribution;Structure;Superhelical DNA;System;theories;Time;Toy;Tracer;Vertebral column;Work

PROJECT_TITLE: Physical model of the bacteria nucleoid

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_NAME: RETINA FOUNDATION OF THE SOUTHWEST

PHR: Project Narrative Amblyopia, or “lazy eye,” is a neurodevelopmental condition that interferes with the normal development of vision in 2-3% of children. Available treatments are beneficial if the condition is detected during early childhood, but complete recovery of normal vision is achieved in less than 50% of children. Two new approaches to amblyopia treatment will be investigated and findings from these clinical trials will potentially open a new avenue for treatments that restore normal visual function.

PI_NAMEs: BIRCH, EILEEN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Adhesives;Affect;Age;aged;alternative treatment;Amblyopia;Anisometropia;Area;Automobile Driving;Binocular Vision;Child;Childhood;Clinical Trials;Collaborations;Compensation;Data;Development;Disease;Disparity;early childhood;Educational Materials;Effectiveness;Equilibrium;Exhibits;experience;Eye;eye hand coordination;Functional disorder;Glass;Goals;Hour;improved;Individual Differences;Investigation;Lazy Eyes;Life;Long-Term Potentiation;luminance;Modification;Monitor;monocular;Motor Skills;neurodevelopment;Neuronal Plasticity;Neurons;novel;novel strategies;Ophthalmologist;Outcome;Pathway interactions;personalized approach;Photic Stimulation;Physiological;postsynaptic;Psychophysics;Quality of life;randomized, clinical trials;Reading;Recovery;recruit;Research;Residual state;Resolution;response;Risk;Self Perception;Signal Transduction;skills;Speed;standard of care;Strabismus;Strategic Planning;Tablets;technological innovation;Technology;Time;treatment effect;Vision;vision development;Visual;Visual Acuity;visual motor;Visual System;Work

PROJECT_TITLE: Binocular Vision, Amblyopia, and Refractive Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]