ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative One of the major challenges in vaccine development is access to adjuvants that promote long lived pathogen specific CD4+ and CD8+ T cell responses and provide protective cell mediated immunity. Our previous studies identified a molecular adjuvant that uses CD40 and TLR agonists that induces protective long lived T cell populations in mice and primates but why this approach is so effective is unclear. Our preliminary data indicate that dendritic cell production of IL-27 activates metabolic changes in recently primed T cells that result in sustained cMyc activation required for this long-lived response. This project will will use intravital imaging of T– DC interactions and the manipulation of IL-27, DC functions and c-Myc pathways to understand the mechanistic determinants that determine the efficacy of combined CD40L/TLR adjuvant. These data sets will be integrated into a stochastic agent-based mathematical model to predict and validate the key events involved in long lived T cell memory formation.

PI_NAMEs: ADAMS, THOMAS A;HUNTER, CHRISTOPHER A;KEDL, ROSS M (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adjuvant;Agonist;antigen challenge;Antigen Presentation;Biological Models;Biomass;c-myc Genes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Survival;Cellular biology;Cellular Immunity;Clonal Expansion;Computer Models;cytokine;Cytokine Activation;Data;Data Set;Dendritic Cells;design;Development;efficacy evaluation;Elements;Evaluation;Event;fatty acid oxidation;gain of function;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;genetic approach;Genetic Transcription;Hexosamines;Histocompatibility Antigens Class I;Human Resources;imaging approach;Immune;Immunity;Immunologic Memory;Immunology;in vivo;Infection;innovation;Interleukin-15;intravital imaging;Laboratories;loss of function;mathematical model;Mathematics;Mediating;Memory;Metabolic;Methods;Mitochondria;Modeling;Molecular;multiphoton imaging;Mus;Natural Immunity;nonhuman primate;pathogen;Pathway interactions;Population;predictive modeling;Primates;Production;Productivity;programs;Publishing;rational design;Reporter;Research;response;Role;Signal Pathway;Signal Transduction;Subunit Vaccines;System;T cell response;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;TCR Activation;Testing;TNFRSF5 gene;TNFSF5 gene;transcription factor;Vaccination;Vaccine Design;vaccine development;vaccine trial;Vaccines;Validation

PROJECT_TITLE: Mechanisms of combined CD40/TLR adjuvant-elicited cellular immunity


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Opioids are commonly prescribed analgesics with high addictive potential, but we do not fully understand the signaling pathways that cause analgesia versus addiction. Here, I propose to (1) investigate the spatiotemporal dynamics of one opioid-induced intracellular signaling pathway and (2) define this pathway’s role in analgesia. By identifying key brain regions and cell types in which this signaling occurs and the direct functional consequence of this signaling, this work will extend our understanding of opioid modulation of pain circuitry.

PI_NAMEs: BAYLESS-EDWARDS, LANDON  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Absence of pain sensation;Acute;addiction;Adenylate Cyclase;Affect;Affective;Agonist;Analgesics;antagonist;Anterior;Behavior;Behavioral Assay;behavioral study;brain cell;Brain region;cell type;Cells;Chronic;cingulate cortex;Complex;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Dendrites;dermorphin;design;experimental study;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;Goals;GTP-Binding Proteins;hippocampal pyramidal neuron;Hour;Hyperalgesia;Image;In Vitro;in vivo;in vivo imaging;insight;interest;Interneurons;Label;Measures;Mediating;Membrane;Methodology;Modeling;Morphine;morphine administration;Motivation;mu opioid receptors;Mus;Nature;negative affect;neuronal cell body;Neurons;novel;Opioid;Opioid agonist;opioid exposure;Opioid Receptor;opioid use disorder;Pain;pain behavior;Pain Measurement;pain relief;Pathway interactions;Peptides;photoactivation;Play;Positioning Attribute;Production;Property;Protein Dynamics;Protein Kinase A Inhibitor;Public Health;receptor;Receptor Activation;receptor expression;regional difference;Regulation;Research;Resolution;response;Rewards;Role;sensor;Sensory;sensory integration;Signal Pathway;Signal Transduction;Site;spatiotemporal;Specificity;stem;Synapses;Testing;Thalamic structure;two-photon;Work

PROJECT_TITLE: Intracellular signaling mechanisms underlying opioid modulation of pain


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Interstitial Cystitis;Mental Health;Neurosciences;Pain Research;Physical Activity;Prevention;Social Determinants of Health;Urologic Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Experiencing early life stress or trauma increases the likelihood of developing chronic pain and mood disorders later in life. This is in part due to structural, neurochemical, and epigenetic changes within the brain that regulate the response to stress and the perception of pain. We will determine if increasing physical activity can attenuate these central changes and reduce stress-induced symptom exacerbation.

PI_NAMEs: CARLSTEN CHRISTIANSON, JULIE A (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acute;acute stress;Adult;Affective;allodynia;associated symptom;Attenuated;Automobile Driving;Behavior;Bilateral;biological adaptation to stress;Bladder;Brain;Brain-Derived Neurotrophic Factor;central pain;chronic painful condition;Clinical;comorbidity;Development;DNA;DNA Methylation;early experience;early life stress;effective therapy;Epigenetic Process;Exercise;Exhibits;Exposure to;Female;Gene Expression;Genes;Genitourinary system;gray matter;Hippocampus;Hypersensitivity;hypothalamic-pituitary-adrenal axis;Impairment;improved;in vivo;inflammatory marker;inhibitor;Life;Magnetic Resonance Imaging;Major Depressive Disorder;male;maternal separation;Measures;Mediating;Methylation;Modeling;Modification;Mood Disorders;Moods;mouse model;Mus;negative mood;Neonatal;neurochemistry;neurogenesis;neuroimaging;novel;Outcome;Output;Pain;Pain Disorder;pain perception;pain processing;Patients;Pelvic Pain;Phenotype;Physical activity;Population;Populations at Risk;Predisposition;prevent;Process;Prostate;Recording of previous events;Regulation;Reporting;response;Rewards;Running;sedentary;Severities;sex;Signal Transduction;Spectrum Analysis;Stress;stress reduction;Symptom Burden;symptomatic improvement;Symptoms;Testing;Therapeutic Intervention;Trauma;Urination;urologic chronic pelvic pain syndrome;Vagina;Water

PROJECT_TITLE: Effect of neonatal and adult stress on pelvic pain disorders and comorbidity


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Sexually receptive behavior in female rodents, lordosis, is a prototypical social behavior that is dependent on sex steroids. How neural circuitry that controls social behavior interacts with hypothalamic circuits will provide a circuit level understanding of the neural control of motivated behavior.

PI_NAMEs: MICEVYCH, PAUL E (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acute;Affect;Amygdaloid structure;Animal Model;Behavior;behavior test;beta-Endorphin;Cell Nucleus;Dependovirus;Dorsal;Estradiol;expectation;experimental study;Female;FOS gene;Glutamates;Goals;Gonadal Steroid Hormones;Halorhodopsins;Hormonal;Hypothalamic structure;immunoreactivity;Lasers;Light;Lordosis;male;Measures;Medial;medial preoptic nucleus;Mediating;Membrane;Methods;Morphology;motivated behavior;mu opioid receptors;Mus;neural circuit;Neurons;neuroregulation;Opioid;Opioid Receptor;optogenetics;Output;Ovariectomy;Pattern;preoptic nucleus;Progesterone;prototype;Regulation;Reproductive Behavior;response;Rodent;Role;Sensory;Signal Transduction;Site;social;Social Behavior;Social Controls;Social Interaction;Steroids;Stimulus;Structure of nucleus infundibularis hypothalami;Testing;Work

PROJECT_TITLE: Modulation of sex steroid-induced female social behaviors in an animal model

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Restoration of upper extremity function following damage to the central nervous system is a challenge faced by many people, particularly those who have survived a stroke. The proposed research will determine mechanisms controlling bimanual coordination and muscle activation patterns of goal-directed reaching while exoskeleton and virtual reality systems provide an environment that promotes paretic limb use in stroke survivors. The knowledge gained from this work will provide clinicians and researchers technological solutions to therapeutic challenges.

PI_NAMEs: BRUNFELDT, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 3D virtual reality;Activities of Daily Living;Acute;acute stroke;Adopted;American;arm;arm function;biceps brachii muscle;Bilateral;Biological Assay;Biomedical Engineering;career;Cause of Death;Central Nervous System;Chronic Phase;chronic stroke;Clinical;Collaborations;control theory;Couples;Coupling;Custom;Data;deltoid muscle;design;disability;efficacious treatment;Electromyography;Engineering;Environment;exoskeleton;experience;Feedback;Force of Gravity;Functional impairment;Future;Goals;Hand;hemiparesis;Hemiplegia;Hospitals;Impairment;improved;Individual;individual patient;innovation;Institution;kinematics;Knowledge;Learning;Limb structure;Manuals;Measures;Mentors;Mentorship;Monitor;motor control;Movement;Muscle;neural;Neurology;neuromuscular;Neurons;next generation;novel;novel strategies;Output;Paresis;Participant;Patients;Pattern;Persons;Phenotype;Process;Publications;Recovery of Function;recruit;Regulation;rehabilitation science;Rehabilitation therapy;Reporting;Research;Research Personnel;Resistance;restoration;Stroke;stroke patient;stroke rehabilitation;stroke survivor;Sum;Surface;System;Techniques;Technology;Testing;Therapeutic;Tissues;Training;Translating;United States;Universities;Upper Extremity;virtual;virtual reality;virtual reality environment;virtual reality system;Visual;Weight;Work

PROJECT_TITLE: Promoting paretic limb use in stroke survivors using exoskeleton and virtual reality technologies


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The ability to treat and prevent illness and improve human health requires not only a detailed understanding of the complex interplay of biological systems contributing to disease processes but also the mechanisms underlying the influence of social complexity on biological systems. The systems science approach provides methods uniquely suited to elucidate the mechanisms by which social systems influence health. The proposed research adopts this approach by modeling the short- and long-term effects of social interventions on the multiscale and multilayer networks and their effects on biomarkers of individual health in a well- established nonhuman primate model.

PI_NAMEs: MCCOWAN, BRENDA  (contact)

PROGRAM_OFFICER_NAME: MANN KOEPKE, KATHY M

PROJECT_TERMS: Address;Adopted;Affect;Biological Markers;biological systems;Cardiovascular Physiology;Communities;Complex;design;Desire for food;Development;Disease;disorder risk;efficacious intervention;Exhibits;experience;experimental study;Family;Future;Goals;Health;Human;Immune;improved;Individual;Intervention;Kidney;Life;Link;Liver;Long-Term Effects;Measures;Medical Research;Methods;Modeling;motherhood;nonhuman primate;Outcome;Pathway interactions;Physiological;Physiological Processes;Physiology;Play;Population;Positioning Attribute;prevent;Prevention;Primary Prevention;Process;Public Health;Research;Resources;Role;Science;Series;Shapes;social;Social Environment;social influence;Social Interaction;social interventions;Social Network;social relationships;Social support;Source;System;Testing;Time;Translations

PROJECT_TITLE: Effects of Altering Social Connectedness on  Health


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative  The average human genome contains ~100 active Long INterspersed Element-1 (LINE-1 or L1) sequences that can mobilize to new genomic locations by a process known as retrotransposition. L1 retrotransposition events in the germ line, during early development, or in somatic cells generate inter- and intra-individual genetic diversity and are implicated in a myriad of sporadic genetic diseases, including Hemophilia A, Duchenne muscular dystrophy, and certain cancers. The goal of this R01 proposal is to use a cultured cell retrotransposition assay in conjunction with an integrative strategy that involves genetic, molecular biological, biochemical, multi- omic, and computational approaches to: (i) elucidate how L1s move to new genomic locations; and (ii) determine how host factors act to restrict or facilitate L1 retrotransposition. This knowledge will provide insights into how L1 retrotransposition contributes to human disease, human genetic variation, and human genome evolution.

PI_NAMEs: MORAN, JOHN V. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 3' Untranslated Regions;5' Splice Site;5' Untranslated Regions;access restrictions;Address;Affect;Ataxia Telangiectasia;ataxia telangiectasia mutated protein;Binding Proteins;Biochemical;Biological;Biological Assay;Biology;Cells;Collaborations;Complex;Cultured Cells;Cytidine Deaminase;Data;Deoxyribonucleases;Development;DNA;DNA biosynthesis;DNA Damage;DNA Transposable Elements;Duchenne muscular dystrophy;endonuclease;Engineering;Epitopes;Event;Evolution;experience;Experimental Models;Family;Foundations;Genetic;genetic analysis;Genetic Diseases;Genetic Variation;Genomic DNA;genomic locus;Germ Lines;Goals;Hemophilia A;Hemophilia B;Human;human disease;Human Genetics;Human Genome;Immobilization;Immunoprecipitation;Individual;insight;Integration Host Factors;Knowledge;Laboratories;Laboratory Study;Length;Long Interspersed Elements;Malignant Neoplasms;Mass Spectrum Analysis;member;Messenger RNA;Michigan;Mobile Genetic Elements;Molecular;Molecular Analysis;multiple omics;Mutation;Open Reading Frames;Poly(A) Tail;Poly(ADP-ribose) Polymerases;Polymerase;prevent;Process;promoter;protein protein interaction;Proteins;Reading Frames;Reagent;recruit;replication factor A;Research;response;Retrotransposition;Retrotransposon;RNA Splicing;RNA-Directed DNA Polymerase;Site;Somatic Cell;Structure;success;Testing;Time;Transcript;Translating;Universities;Viral Proteins;X Chromosome;Zinc Fingers

PROJECT_TITLE: Genetic and Molecular Analyses of Human LINE-1 Retrotransposition

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Osteoporosis

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project will examine the fundamental basis by which intercellular communication by bone cells can affect the local skeletal tissue remodeling response, which contributes to bone mass, bone quality, and the effectiveness of bone anabolic therapies. These findings will have implications on skeletal fragility, osteoporosis, and methods to optimize bone health.

PI_NAMEs: STAINS, JOSEPH P. (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Achievement;Affect;Age;Aging;Anatomy;Area;Biological;Biological Models;Biology;Biophysics;bone;bone cell;bone health;bone mass;bone quality;Bone remodeling;Bone Resorption;Cells;Communication;Complex;conditional knockout;Connexin 43;Connexins;cortical bone;Coupled;Cues;Cyclic AMP;Data;Defect;Dinoprostone;Effectiveness;Effector Cell;Ensure;Event;experience;Exposure to;Failure;Femur;Funding;gap junction channel;Gap Junctions;Goals;Grant;Growth Factor;Homeostasis;Hormones;In Vitro;in vivo;Inositol Phosphates;insight;intercellular communication;Knowledge;Location;Maintenance;mechanical load;mechanical signal;Mechanics;mechanotransduction;Methods;Modeling;Molecular;molecular mass;Mus;Mutation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;osteoprogenitor cell;overexpression;Pathway interactions;Phenotype;Physiological;Play;Population;PTH gene;Publishing;receptor expression;Regulation;response;restraint;Role;Second Messenger Systems;segregation;Signal Transduction;skeletal;skeletal disorder;skeletal tissue;Source;Stimulus;Surface;Testing;Thick;Tissues;TNFSF11 gene;Translations;transmission process

PROJECT_TITLE: Spatial Control of Bone Remodeling by Gap Junction-Communicated cAMP

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: G protein-coupled receptors (GPCRs) modulate neuronal activity and synaptic transmission in response to a variety of neuromodulators that regulate learning and memory, cognition, mood, and many other neural processes. However, little is known about how GPCRs integrate different neuromodulatory signals to activate distinct downstream signaling patterns in vivo. Therefore, the proposed experiments will use genetically encoded Förster resonance energy transfer (FRET) -based sensors and optical imaging techniques to monitor cellular and subcellular signaling pathways during the induction of long-term synaptic plasticity and during learned behaviors in ex vivo and in vivo experiments, respectively.

PI_NAMEs: AUGUSTIN, SHANA M (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acceleration;Address;Adenylate Cyclase;adenylyl cyclase type V;Advisory Committees;Affect;Anatomy;Animals;Basal Ganglia;Behavior;Behavioral;behavioral response;Brain;brain tissue;career;Cell Culture Techniques;cell type;Cells;Cognition;Committee Members;Communication;Corpus striatum structure;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Decision Making;design;Development;Disease;Dissociation;Dorsal;Drug Targeting;Drug usage;Energy Transfer;Ensure;Equilibrium;Etiology;Experimental Designs;experimental study;Extramural Activities;Faculty;Fiber;Fiber Optics;fluorescence lifetime imaging;Fluorescence Resonance Energy Transfer;Fostering;G-Protein-Coupled Receptors;GTP-Binding Proteins;Hormones;Image;Imaging Techniques;Impairment;improved;in vivo;information processing;innovation;interest;Lateral;learned behavior;Learning;Learning Skill;Ligand Binding;Ligands;Link;Lipids;Location;Locomotion;Long-Term Depression;Measures;Mediating;Medicine;Memory;Mentors;Molecular Profiling;Molecular Target;Monitor;Moods;Motor;motor skill learning;Mus;Nervous System Disorder;neural;Neuromodulator;neuronal excitability;Neurons;neuroregulation;neurotransmission;optical imaging;Outcome;Parkinson Disease;Pathway interactions;Pattern;Performance;Periodicity;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Photometry;Photons;Physiological;Physiological Processes;Positioning Attribute;postsynaptic;Preparation;Process;Proteins;Publishing;receptor;recruit;Reporter;Research;Research Personnel;response;Running;Second Messenger Systems;sensor;Signal Pathway;Signal Transduction;Signaling Protein;skills;small hairpin RNA;Smell Perception;spatiotemporal;Specificity;Students;Synapses;Synaptic plasticity;Synaptic Transmission;System;tenure track;Testing;Time;Tissue imaging;tool;Training;Transgenic Mice;two-photon;Viral

PROJECT_TITLE: Deep brain live imaging of cAMP and protein kinase A activities underlying synaptic- and circuit-level mechanisms during learned behaviors

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE Distinct anatomical subregions of the striatum are known to make unique contributions to different aspects of sensor-motor learning, and region-specific striatum dysfunction has been attributed to a range of symptoms in neurological disorders. How cell-type specific striatum dynamics evolve during learning to support adaptive learning is poorly understood. This proposal will advance new optical approaches to determine how distinct output signals evolve across the entire striatum during learning and how they are shaped by ongoing neuromodulatory input, providing fundamental insight into circuit level mechanisms of normal behavior and potential targeted therapeutics for disease.

PI_NAMEs: HOWE, MARK W (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: 3-Dimensional;adaptive learning;addiction;Address;Anatomy;Association Learning;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavioral;behavioral study;Brain;Calcium;Cell Nucleus;cell type;Cells;Corpus striatum structure;Cues;density;Disease;Dopamine;Exhibits;Fiber;Functional disorder;Ganglia;Goals;Head;Image;In Vitro;in vivo;Individual;insight;Knowledge;Learning;Learning Disorders;Link;Location;Measurement;Measures;Mediating;Mediator;Midbrain structure;Modeling;Monitor;motivated behavior;Motivation;motor learning;Movement;Mus;Nervous System Disorder;neural;Neuromodulator;Neurons;neuroregulation;novel;Optics;Output;Parkinson Disease;Pathway interactions;Pattern;Performance;Phase;Population;Population Dynamics;Resolution;response;Rewards;Role;sensor;Shapes;Signal Transduction;Slice;spatiotemporal;Stimulus;Structure;Symptoms;Synaptic plasticity;targeted treatment;Testing;two-photon;Variant

PROJECT_TITLE: Striatum Wide Dynamics and Neuromodulation of Cell-Type Specific Striatum Populations during Learning

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative: While the tissue interactions that regulate development of the upper jaw are known, the regulation of gene expression remains elusive. Yet, this information is essential for understanding the structural dysmorphologies, such as cleft lip and palate, that occur in this region. In this work, we will utilize our knowledge of the tissue interactions that control morphogenesis to uncover the genetic regulatory landscape that is responsible for facial morphogenesis. !

PI_NAMEs: MARCUCIO, RALPH S (contact);SELLERI, LICIA

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: ATAC-seq;B-Cell Acute Lymphoblastic Leukemia;Binding;Biological Assay;Birds;Brain;Catalogs;cell motility;Cells;Chick;Chick Embryo;ChIP-seq;Chromatin;Cleft Lip;cleft lip and palate;Cleft Palate;Competence;Complex;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial complex;Data;Data Set;design;Development;Developmental Biology;Disease;Dysmorphology;Ectoderm;Ectoderm Cell;Embryo;Enhancers;Etiology;Excision;Exhibits;experimental study;Face;Fibroblast Growth Factor 8;Foundations;gain of function;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genetic variant;Genomic approach;global run on sequencing;Goals;Growth;Holoprosencephaly;Homeobox;Homeobox Genes;homeodomain;Human;innovation;Jaw;Kinetics;Knowledge;Laboratories;Limb structure;Location;loss of function;Maintenance;member;Molecular;Morphogenesis;Morphology;Mus;Neural Crest;Neural Crest Cell;neurotransmission;Nose;Organ;Outcome;Patients;Pattern;PBX3 gene;Process;Prosencephalon;Regulation;Regulator Genes;Regulatory Element;Repression;Research;response;risk variant;Role;Shapes;SHH gene;Signal Transduction;smoothened signaling pathway;Solid;Sonic Hedgehog Pathway;Surface Ectoderm;Testing;Time;Tissues;transcription factor;Work

PROJECT_TITLE: Transcriptional regulatory landscapes underlying FEZ Formation


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative This project will use our unique complement-related knock-out rats, mice, as well as contemporary in vitro techniques to study the mechanism by which complement facilitates paclitaxel-induced neuropathic pain and to develop novel complement-targeted therapies for this devastating side effect of chemotherapy.

PI_NAMEs: XU, JIJUN  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: activation product;Afferent Neurons;Alcohol consumption;Alcohols;Anaphylatoxins;Animals;antagonist;Antibodies;attenuation;behavior test;Bladder;Breast;C3AR1 gene;Calcium;Cancer Control;Cancer Patient;CCL2 gene;cell injury;Cells;chemokine;Chemotactic Factors;chemotherapy;Clinical;Collection;Complement;Complement 3a;Complement 5a;Complement Activation;Complement Inactivators;Complement Membrane Attack Complex;Complement Receptor;Deposition;Development;Diabetes Mellitus;Distal;Dose;effective therapy;Engineered Gene;FDA approved;Foundations;Future;HIV Infections;In Vitro;in vivo;Incubated;Infiltration;Inflammation;Ion Channel;Knock-out;Knockout Mice;Limb structure;Lung;Macrophage;mechanical allodynia;Mediating;Mus;Natural Immunity;Nerve Fibers;neuronal cell body;Neurons;novel;Ovarian;Paclitaxel;Pain;Pain Measurement;pain receptor;painful neuropathy;Pathogenesis;Patients;Peripheral;Peripheral Nervous System Diseases;Permeability;Pharmaceutical Preparations;Physicians;Pilot Projects;Plasma;Play;prevent;Production;Quality of life;Rattus;Reagent;receptor;Receptor Signaling;recruit;Reporting;Rodent;Role;Serum;side effect;Signal Transduction;Solid;Solid Neoplasm;Source;Spinal Cord;Spinal Ganglia;Surface;Syndrome;targeted treatment;Techniques;Testing;Therapeutic Effect;Time;transmission process;Up-Regulation;Vanilloid;Wild Type Mouse;Work

PROJECT_TITLE: Complement in Paclitaxel-induced peripheral neuropathy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Kidney Disease;Microbiome;Prevention

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: PROJECT NARRATIVE Recent advances in microbial DNA sequencing have identified highly diverse microbial communities in the systemic circulation (a.k.a. circulating microbiome) among patients with chronic inflammatory diseases even without overt infection; however, the characteristics and roles of circulating microbiome in patients with end- stage renal disease (ESRD) remains largely unknown. Our proposed studies aim to determine the levels, composition, and temporal changes of the circulating microbiome and their associations with clinical characteristics and outcomes in ESRD patients. This research will have the potential to discover novel pathophysiologic roles of the circulating microbiome in ESRD, leading to the development of new diagnostic and prognostic biomarkers and target-driven therapeutic strategies to reduce excess mortality risk in ESRD patients.

PI_NAMEs: SUMIDA, KEIICHI  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Age;Archaea;Bacteria;bacterial community;Bacterial DNA;Bacterial Translocation;Biological;Blood;Blood Circulation;Blood specimen;burden of illness;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular system;Catheters;Characteristics;Chronic;chronic inflammatory disease;Chronic Kidney Failure;Circulation;Clinical;Clinical Data;cohort;Data;Development;diagnostic biomarker;Dialysis procedure;DNA;DNA sequencing;effective therapy;End stage renal failure;Endotoxins;Excess Mortality;fungus;Future;Goals;Graph;Hemodialysis;high risk;Human;Impairment;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Intestinal Mucosa;Intestinal permeability;Intestines;Link;Liver Cirrhosis;longitudinal analysis;Mediating;Mediator;metagenomic sequencing;microbial;microbial community;microbiome;microorganism;modifiable risk;Morbidity - disease rate;mortality;mortality risk;Nature;novel;novel diagnostics;Outcome;participant enrollment;Patients;premature;Premature Mortality;Prevalence;Prognostic Marker;Property;Prospective cohort;Proteobacteria;Psychological Techniques;Public Health;Regression Analysis;Research;Resources;Risk;Risk Factors;Role;Route;Site;supercomputer;Taxonomy;Techniques;Testing;Therapeutic;therapeutic target;Work

PROJECT_TITLE: Circulating microbiome and premature mortality in hemodialysis patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: NARRATIVE We propose to evaluate a combination therapy to enhance the effectiveness of chimeric antigen receptor (CAR) T cells for malignant glioma (MG) by relieving tumor-induced immune suppression using the anti-PD-1 antibody nivolumab. We anticipate that CAR T cells will directly target antigen-positive glioma cells and that anti-PD1 will augment endogenous and CAR T cell responses. The proposed studies aim to improve our understanding of the glioma microenvironment and identify key drivers of response or resistance to combining CAR T and anti- PD-1 immunotherapies.

PI_NAMEs: BADIE, BEHNAM ;BROWN, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Animals;anti-cancer;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;Antigen Targeting;Antigens;Biology;cancer therapy;CAR T cell therapy;Cells;Cerebrospinal Fluid;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Cities;Clinical;clinical candidate;Clinical Trials;cohort;Combined Modality Therapy;CXCL10 gene;CXCR3 gene;design;Disease;Effectiveness;Environment;experience;experimental study;Generations;Glioblastoma;Glioma;Goals;Hematologic Neoplasms;IL13RA1 gene;Immune;immune checkpoint blockade;immune resistance;Immunocompetent;Immunologics;Immunophenotyping;Immunosuppression;Immunotherapy;improved;improved outcome;In complete remission;innovation;insight;interleukin-13 receptor;Intraventricular;Lead;Letters;Malignant Glioma;manufacture;Mediating;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;Nivolumab;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 blockade;PD-1/PD-L1;PDL1 pathway;Phase;Phase I Clinical Trials;phase I trial;Phenotype;Population;Positioning Attribute;pre-clinical;preclinical study;programmed cell death ligand 1;programmed cell death protein 1;programs;recruit;Recurrence;research clinical testing;Resistance;response;Role;Safety;safety and feasibility;Sampling;Solid Neoplasm;standard of care;success;synergism;T cell response;T cell therapy;T-cell inflamed;T-Cell Receptor Therapy;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;therapeutic development;therapy resistant;timeline;Translating;Treatment Efficacy;tumor;tumor microenvironment;Vertebral column

PROJECT_TITLE: Clinical evaluation of IL13Ra2-targeted CAR T cell therapy in combination with nivolumab in patients with recurrent malignant glioma

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The rate of aging of the breast shows high level of variability between women. This application focuses on the role of mitochondrial genetics in the regulation of the rate of aging of the breast and the increase susceptibility of aged breast to develop estrogen receptor alpha positive breast cancer.

PI_NAMEs: GERMAIN, DORIS A (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: Affect;African;Age;age related decline;aged;Aging;Agreement;Alveolar;Alveolar Cell;Automobile Driving;Basal Cell;Breast;Breast Cancer Model;cancer subtypes;Cells;Centenarian;Complex;Data;Endoplasmic Reticulum;ERBB2 gene;ESR1 gene;Estrogens;Etiology;European;Evolution;Female;gain of function;Genetic;Genetic Transcription;Genome;Genotype;Haplotypes;high risk;Hormonal;Hormones;Individual;Injections;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Duct;Mammary gland;Mammary Neoplasms;Mediating;Menopause;Mitochondria;Mitochondrial DNA;mitochondrial fitness;Monitor;Mouse Mammary Tumor Virus;mouse model;Mus;Nuclear;old mice;older women;Oncogenes;Oxidative Stress;Perimenopause;Population;Postmenopause;Predisposition;Premenopause;preservation;Progesterone;programs;promoter;Proteins;rate of aging;receptor;Regulation;response;Retroviridae;Risk Factors;Role;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Sirtuins;Stress;Testing;transcriptome;transcriptome sequencing;transgene expression;Transgenic Mice;Transgenic Organisms;Trees;tumor;Woman;young adult

PROJECT_TITLE: Understanding the influence of Mitochondrial DNA haplotypes on breast aging and cancer

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative This proposal, Identifying Metabolic and Psychosocial Antecedents and Characteristics of youth-onset Type 2 diabetes (IMPACT DM), will identify the key predictors of youth-onset type 2 diabetes (YOT2D), which is increasing in prevalence among youth, progressing rapidly to treatment failure and micro-and macrovascular complications. Identifying the key predictors will allow for pharmaceutical, physiologic, and psychosocial interventions aimed at preventing youth-onset type 2 diabetes and preserving the function of the β cells to reduce YOT2D associated complications.

PI_NAMEs: TRYGGESTAD, JEANIE BEATRICE (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;adipokines;Adolescent;adverse childhood events;Affect;Algorithms;Beta Cell;Biochemical;Biological Markers;Biological Specimen Banks;blood glucose regulation;Body Composition;C-Peptide;cardiometabolism;Cell Physiology;Central obesity;Characteristics;Child;Childhood;Chronic stress;circulating microRNA;clinical center;clinical predictors;cohort;Complications of Diabetes Mellitus;Continuous Glucose Monitor;cytokine;deprivation;design;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Progression;Early Intervention;Energy Metabolism;Environment;Ethnic Origin;Ethnic Population;exercise capacity;experience;Failure;fasting glucose;Fatty acid glycerol esters;Fructosamine;Glucose;Glycosylated hemoglobin A;Goals;gut microbiome;Health;Health Sciences;High Density Lipoprotein Cholesterol;high risk;Hispanic Americans;Hormones;Hour;Hydrocortisone;Hypertension;in utero;indexing;Insulin;Intervention;macrovascular disease;maternal obesity;Measurable;Measures;Mediating;Mental Depression;Metabolic;metabolomics;Methods;microbiome;MicroRNAs;Microvascular Dysfunction;minority children;Modeling;Morbidity - disease rate;mortality;Native American population;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;obesity in children;OGTT;Oklahoma;Pancreas;Participant;Patient Recruitments;patient retention;Pattern;Pharmacologic Substance;Phenotype;Physiological;Population;Prediabetes syndrome;predictive modeling;Predictive Value;Pregnancy;prenatal exposure;preservation;Prevalence;prevent;Prevention;Prevention strategy;Progressive Disease;Proinsulin;Proteins;psychosocial;Psychosocial Factor;Psychosocial Stress;psychosocial stressors;Puberty;racial minority;racial minority population;Records;recruit;Regression Analysis;Research;Rest;Risk;Risk Factors;Salivary;Serum;Site;socioeconomics;Testing;therapy development;Time;time use;Treatment Failure;treatment optimization;Universities;young adult;Youth


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: In the US, approximately 90,000 amputations are performed annually as a result of diabetic foot ulceration and the VA currently cares for more than half million Veterans at high risk for amputation. The current standard for prevention of plantar foot ulcers in those individuals is specialty diabetic shoes and custom insoles. The purpose of the custom insole is to cushion the feet, evenly distribute pressures, and to selectively offload areas of increased pressure. Advances in 3D printing, materials, and software have enabled new 3D printed metamaterials whose properties are derived not only from the base material but also from lattice microstructures within the metamaterial. We are proposing to redesign diabetic insoles to use 3D printing with patient specific stiffness and structural behavior. The purpose of this grant is to determine if the 3D printed insoles are better at reducing plantar pressures than the traditional insoles. The results of this study can help reduce annual rates of lower limb loss within our Veteran population.

PI_NAMEs: MUIR, BRITTNEY C (contact)

PROJECT_TERMS: 3-Dimensional;3D Print;Amputation;Area;base;Behavior;Caring;Characteristics;Clinic;Clinical;clinical practice;clinical translation;Computer software;cost;Custom;design;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;digital;Effectiveness;Elements;experience;fabrication;Feedback;Financial Hardship;Finite Element Analysis;Foam Cells;Focus Groups;foot;Foot Ulcer;Geometry;Grant;Hand;Head;Healthcare;Healthcare Systems;high risk;imprint;improved;improved outcome;Incidence;Individual;innovation;insight;Judgment;large scale production;Life;limb amputation;limb loss;Lower Extremity;manufacture;manufacturing process;manufacturing technology;Measurement;Measures;Mechanical Stress;medical specialties;Medicine;Metatarsal bone structure;Methods;military veteran;Mission;Morbidity - disease rate;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Patients;Pattern;Performance;Peripheral Nervous System Diseases;Plantar Ulcers;pressure;Prevention;programs;Property;Quality of life;recruit;Reporting;Research Personnel;Risk;Risk Reduction;Shapes;Shoes;simulation;soft tissue;Speed;standard of care;Structure;Surface;Survival Rate;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Translations;Ulcer;ultrasound;Veterans;Walking;Weight-Bearing state

PROJECT_TITLE: Patient Specific 3D Printed Diabetic Insoles to Reduce Plantar Pressure

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: SAINT LOUIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cutting-edge research in Vision Science is increasingly interdisciplinary, and traditional discipline-based Ph.D. programs strain to accommodate this development. The Interdisciplinary Training in Vision Science (ITVS) program at Washington University in Saint Louis provides an integrative model for training 21st century Vision Scientists with a unique set of basic science, translational, and professional skills that effectively position them to produce transformative breakthroughs to understand, preserve, and restore vision. This training grant will support six predoctoral trainees.

PI_NAMEs: CHEN, SHIMING ;KERSCHENSTEINER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training;vision science


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Organ Transplantation;Rural Health;Social Determinants of Health;Telehealth;Transplantation

ORG_CITY: BIRMINGHAM

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE Living kidney donors remain a critical source of organs for their loved ones; yet LDKT has decreased substantially since 2004 particularly in the southeastern US. Existing organ donation educational programs have focused primarily on addressing transplant-candidate factors by separating the advocacy role from the candidates; however, these programs have failed to address potential donor concerns regarding comfort with the evaluation process and have relied on resource intense education aides, which are often not readily available in many under resourced, often rural, areas of the southeastern US. It is critical to develop programs that will ensure sustainable increases in living donation independent of geography.

PI_NAMEs: LOCKE, JAYME ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: access disparities;Address;Adoption;Advocacy;Advocate;Area;Cellular Phone;Characteristics;compare effectiveness;Complex;Consumption;design;Donor Selection;Education;Ensure;Evaluation;Family;Frequencies;Friends;geographic disparity;Geography;Healthcare Systems;improved;improved outcome;Individual;Infrastructure;Internet;Intervention;Kidney;Kidney Transplantation;Knowledge;Living Donors;living kidney donor;loved ones;Maintenance;Methods;Modeling;Monitor;novel;Organ;Organ Donations;Participant;patient navigator;Persons;Physicians;Process;programs;radiological imaging;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Relationship-Building;Research;Resource-limited setting;Resources;Role;Rural;rural area;screening;Services;smartphone application;Source;Southeastern United States;Speed;standard of care;System;Techniques;telehealth;Testing;Time;tool;Training;Training Programs;transplant centers;Transplantation;United States;urban setting;Visit

PROJECT_TITLE: Promoting Increases in Living Organ Donation via Tele-navigation (PILOT)

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The benefit of multipurpose prophylaxis to women with high risk of HIV/STIs infection is significant. Ultra-long- acting injectable formulations providing steady release over several months of antiretroviral drugs in combination with a contraceptive drug can potentially increase compliance to STIs and unplanned pregnancy prophylactic regimen and transform the HIV prevention landscape. The overarching goal of this proposal is to develop and evaluate a first-in-line injectable multipurpose formulation that can contribute to curb the HIV epidemic.

PI_NAMEs: BENHABBOUR, SOUMYA RAHIMA (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Accelerated Phase;Acceleration;Address;Adverse event;Affinity;Africa;AIDS prevention;allergic response;Animal Model;Anti-Retroviral Agents;breakthrough infection;Cervical;Characteristics;chemical property;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;controlled release;Copper Intrauterine Devices;cost effective;Country;Data;design;Development;Drug Delivery Systems;Drug Kinetics;drug release kinetics;efficacy evaluation;efficacy study;Engineering;Epidemic;Etonogestrel;Evaluation;Event;Excipients;experience;Female;Formulation;Fostering;Goals;Grant;Health Benefit;high risk;HIV;HIV Infections;HIV risk;HIV/STD;Human;Implant;implant design;Implantable Infusion Pumps;In Situ;In Vitro;in vivo;Inbred BALB C Mice;Incidence;Infection;Injectable;Injections;innovation;Intramuscular;Lead;Liquid substance;Macaca;Macaca nemestrina;manufacture;Measures;Medroxyprogesterone 17-Acetate;men;Methods;Modeling;Mucous Membrane;Mus;nanoformulation;nanoparticle;nonhuman primate;novel;novel therapeutics;Oral;pathogen;Patients;Performance;Pharmaceutical Preparations;pharmacologic;pharmacometrics;Placebos;Plasma;Polymers;pre-clinical;pre-exposure prophylaxis;Pregnancy;pregnancy prevention;prevent;Prevention;Process;Progestins;Property;prophylactic;Prophylactic treatment;Public Health;Regimen;Research Personnel;Safety;safety assessment;sex;Sexual Transmission;simian human immunodeficiency virus;Subcutaneous Injections;Suspensions;System;Tail;Technology;Testing;Time;Tissues;tool;Toxic effect;transmission process;unintended pregnancy;User Compliance;Vagina;Viral;viral transmission;Woman

PROJECT_TITLE: Ultra-Long-Acting Polymeric Injectable Multi-Purpose Prevention Technology for Contraception and HIV Prevention


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Kidney Disease;Microbiome;Nutrition;Orphan Drug;Patient Safety;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Immunotherapy is a new standard-of-care option for the first-line treatment of intermediate-risk or poor-risk patients with advanced kidney cancer. However, the immunotherapy outcomes are mixed, with some patients achieving complete remissions, and others having no benefit at all. The purpose of this study is to identify and confirm microbiome profiles and bacterial functional pathways associated with cancer immunotherapy response, adverse events, and progression-free survival among patients with advanced kidney cancer.

PI_NAMEs: BILEN, MEHMET ASIM;FEDIRKO, VERONIKA  (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: 16S ribosomal RNA sequencing;Accounting;Adverse event;Aftercare;Biological Markers;Blood;Blood specimen;Butyrates;Cancer Center;cancer immunotherapy;Cancer Patient;cancer therapy;Clinical;Complex;Data;demographics;design;Development;Diagnosis;Diet;Diet Modification;Disease Progression;Disease remission;Ethnic Origin;Ethnic Population;experience;Freezing;Future;Genes;Goals;gut microbes;gut microbiome;High-Throughput Nucleotide Sequencing;Human Microbiome;Immune checkpoint inhibitor;Immunotherapy;improved;Individual;Inflammation;Integration Host Factors;Life Style;Malignant Neoplasms;Measurement;Mediating;men;metagenomic sequencing;microbial;microbiome;Neoplasm Metastasis;Nephrectomy;Outcome;Pathogenesis;Pathway interactions;Patient Recruitments;Patient risk;Patient Selection;Patients;Pharmaceutical Preparations;Phase;prebiotics;prevent;Prevention strategy;Production;Progression-Free Survivals;prospective;Questionnaires;Race;racial population;Recommendation;Recurrent disease;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Resolution;response;Risk;risk stratification;Role;sex;Shotguns;Specific qualifier value;standard of care;stool sample;Supplementation;T-Cell Activation;Time;Toxin;Treatment outcome;treatment response;Treatment-related toxicity;United States;Universities;Validation;Volatile Fatty Acids;whole genome;Woman

PROJECT_TITLE: Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Relevance There are no effective therapies for the emerging resistant fungal pathogens that are becoming an increasing threat to the public health. The goals of this project are to further develop a drug from a promising new antifungal class to address this unmet clinical need for growing immunocompromised patient populations.

PI_NAMEs: ANDES, DAVID R (contact);BUGNI, TIMOTHY S

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Address;analog;Animals;anti-fungal agents;Anti-Infective Agents;antimicrobial;Aspergillosis;Bacteria;Bacterial natural products;Candida auris;Candidiasis;Characteristics;Chemicals;Clinical;clinical development;clinically relevant;Column Chromatography;Crystallization;Data;Data Set;design;Dose;drug development;drug discovery;Drug Formulations;Drug Industry;drug production;Drug resistance;Drug Targeting;effective therapy;efficacy study;efficacy testing;Environment;Exhibits;Formulation;Fungal Drug Resistance;fungus;genomic tools;Goals;Harvest;High Pressure Liquid Chromatography;Human;Immunocompromised Host;improved;In Vitro;in vivo;indexing;industry partner;Infection;Investigation;Lead;lead optimization;Libraries;Marine Invertebrates;Measures;metabolomics;microbiome;Modeling;mouse model;Multiple Fungal Drug Resistance;Mus;Mycoses;Natural Products;Natural Products Chemistry;next generation;novel;pathogen;pathogenic fungus;Pathway interactions;patient population;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;pre-clinical;Predisposition;Production;Property;Public Health;Rattus;Regimen;Research;Resistance;Resources;Safety;safety study;screening;Series;Solubility;Source;symbiont;Technology;Therapeutic;Therapeutic Index;Toxic effect;trafficking;Wisconsin;Work

PROJECT_TITLE: Symbiotic-based discovery of turbinmicin, a safe and selective antifungal against resistant fungi

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Q(83)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: AMHERST

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE  Successful antigen delivery to effector cells of the immune system is crucial in eliciting a potent immunotherapeutic response. This proposal will utilize novel antigen delivery technology with the goal of developing new immunotherapies to be directed at cancer (the focus of this application) and more general future vaccine-related applications (across a range of disease types).

PI_NAMEs: MUHITCH, JASON B;PFEIFER, BLAINE A. (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Adjuvant;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Antitumor Response;Autologous;Biocompatible Materials;Biological;Biological Assay;Biomedical Engineering;cancer immunotherapy;Cancer Patient;CD80 gene;CD86 gene;Cell Communication;Cell Maturation;cell preparation;Cell Separation;Consensus;cytokine;Cytotoxic T-Lymphocytes;Data;delivery vehicle;Dendritic cell activation;dendritic cell vaccination;Dendritic Cells;design;Development;Disease;disease model;Disparate;Effectiveness;Effector Cell;Engineering;experimental study;flexibility;Flow Cytometry;Future;Gene Delivery;Genetic;glycosylation;Goals;Hand;Human;Hybrids;Immune;immune checkpoint blockade;Immune response;Immune system;Immunization;Immunologist;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Individual;interfacial;Interleukin-12;Intracellular Transport;Kinetics;Location;lymph nodes;macromolecule;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;meter;Methods;Modeling;Monitor;monocyte;mouse model;Mus;novel;Outcome;Patients;Peptides;Phase II Clinical Trials;phase III trial;Plasmids;Polymers;Positioning Attribute;Protocols documentation;Qualifying;rare cancer;Reporter;Research;response;Sampling;Science;Series;Signal Transduction;Site;Surface;System;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;trafficking;translational impact;tumor;Tumor Antigens;Tumor Expansion;Vaccination;vaccine platform;Vaccines;Variant;vector;Visualization

PROJECT_TITLE: Targeted Gene Delivery and Human Dendritic Cell Maturation Through a Novel Hybrid Biological-Biomaterial Vector System

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: Bone healing remains a challenge in orthopaedics. We have identified a new bone healing agent that may not only improve bone healing but may also decrease the associated pain. The latter, could replace the necessity of opioids for pain management and serve as an important step in fighting the current opioid crisis.

PI_NAMEs: KACENA, MELISSA A (contact)

PROJECT_TERMS: Abdomen;Acute Pain;addiction;Afferent Neurons;Age;Analgesics;Animals;Aspartic Acid;Autologous Transplantation;AVIL gene;Biological;Biosensor;BMP2 gene;bone;Bone callus;bone fracture repair;bone healing;bone loss;Bone Marrow;Bone Morphogenetic Proteins;Bone Pain;Bone Regeneration;bone repair;cancer risk;CASP1 gene;cell growth;Cell Lineage;Cells;Cervical;Chest;chronic pain;Conditioned Culture Media;cytokine;Data;Defect;disability;Drug usage;FDA approved;Femur;fighting;Forelimb;Fracture;Genes;Growth;Harvest;healing;Health;Healthcare Systems;Hindlimb;Hip region structure;Histone Deacetylase;Image;Impaired cognition;Impairment;Implant;improved;In Vitro;in vivo;in vivo imaging system;Inflammasome;Inflammation;Inflammatory;inflammatory marker;injured;Injury;Limb Bud;limb injury;Lower Extremity;Mechanics;Mediating;Mesenchymal;Mesenchyme;Messenger RNA;Monitor;Mus;Nerve Degeneration;Nervous System;Neurites;Neuropathy;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Opioid;opioid epidemic;Orthopedics;Pain;pain behavior;Pain management;Pain Measurement;pain reduction;paracrine;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Postoperative Pain;Postoperative Period;PPAR gamma;Prevention;Process;Proliferating;promoter;Property;Proteins;Recovery;side effect;SIRT1 gene;Site;skeletal;skeletal injury;spatiotemporal;Spinal Fusion;Spinal Ganglia;Stimulus;Stromal Cells;Surgeon;surgical pain;Techniques;Testing;Tissues;Titrations;TP53 gene;transcriptome sequencing;Transgenic Mice;Trauma;Veterans;Work

PROJECT_TITLE: "Novel therapeutic approaches to improve fracture healing while reducing pain behavior"

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: The United States Department of Veterans Affairs spends an estimated $1.5 billion a year on healthcare for patients with diabetes. The prevalence and complications of diabetes increase with age. Therefore, with the aging of the US and Veteran populations, there is an expectation of increased healthcare costs associated with treating diabetes and the associated complications of this disorder. One common complication is the diabetic foot ulcer. Diabetic foot ulcers are expensive to treat, can take a long time to heal and result in a decrease in patient quality of life. Patients remain susceptible to developing more foot ulcers over time. The goal of this project is to reduce the time it takes to heal a diabetic foot ulcer, increase the time between episodes of ulceration and improve the quality of life for diabetic foot ulcer patients.

PI_NAMEs: MURIUKI, MUTURI G (contact)

PROJECT_TERMS: Address;Adherence;Adult;Affect;Age;Aging;base;behavior change;Blood Glucose;Caring;Clinic Visits;Clinical;Clinical Data;Collaborations;comorbidity;Complication;Complications of Diabetes Mellitus;Computers;Consensus;Control Groups;cost;Counseling;Data;Development;Diabetes Mellitus;Diabetic Foot Ulcer;diabetic patient;Disease;Diurnal Rhythm;Education;Educational Materials;effectiveness measure;expectation;foot;Foot Ulcer;Fostering;global health;Goals;group intervention;healing;Health;Health Care Costs;Health Expenditures;Healthcare;Healthcare Systems;high risk;Holidays;Home;Hospitals;improved;improved outcome;indexing;Intervention;Knowledge;Link;Location;Measures;Medical;Medical Records;Mental Depression;Mental Health;Methods;military veteran;mortality risk;motivational enhancement therapy;Obesity;Orthotic Devices;Outcome;Patient Care;Patient Compliance;Patient Education;patient oriented;Patient Participation;Patient-Focused Outcomes;Patients;Pattern;Peripheral arterial disease;Play;Podiatry;Post-Traumatic Stress Disorders;Predisposition;Prevalence;Prevention;Provider;Quality of life;Randomized, Controlled Trials;Recommendation;Recovery;Regimen;Research;Resources;Role;Schedule;Services;standard of care;Techniques;Testing;Therapeutic;Time;treatment as usual;Treatment Cost;Treatment Effectiveness;Ulcer;United States Department of Veterans Affairs;Variant;Veterans;Visit;walker;Walking;Work;wound

PROJECT_TITLE: Orthotic Treatment of Diabetic Foot Ulcers: Patient Adherence to Prescribed Wear and Effectiveness of Treatment


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Young transgender women are at exceptionally high risk for HIV infection and need innovative HIV prevention interventions that to reduce HIV incidence within this group. LifeSkills Mobile is an mHealth intervention to promote biobehavioral HIV prevention strategies based on empowerment theory and was developed using a community-based participatory research approach. We previously demonstrated the efficacy of Project LifeSkills (the only “best evidence” HIV risk reduction intervention for YTW included among the CDC’s compendium of evidence-based interventions), a group based, face-to-face delivered HIV prevention interventions for YTW, and the adapted it to an online-delivered, mobile app platform (containing 4 online modules). We propose to test the efficacy of LifeSkills Mobile in the current application; given inherent limitations to widespread dissemination of face-to-face, group-based interventions, LifeSkills Mobile extends the potential reach of the intervention via the development of a mobile version, and provides content on, and access to, current biobehavioral prevention technologies (e.g., PrEP).

PI_NAMEs: BELZER, MARVIN E;KUHNS, LISA MARY;MIMIAGA, MATTHEW JAMES (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: acceptability and feasibility;Accounting;Address;Adherence;Adult;Affect;Age;AIDS prevention;Antibodies;Anus;Area;Award;Behavior;biobehavior;Birth;California;care systems;Caring;Cellular Phone;cohort;community advisory board;community based participatory research;condoms;cost;Data;Development;Diagnostic Reagent Kits;digital;Disparity;Economics;Educational Curriculum;efficacy evaluation;efficacy testing;efficacy trial;empowerment;Evidence based intervention;experience;Exposure to;Facebook;Feasibility Studies;Feminine;Funding;Gender;Gender Identity;gender minority;Geography;group intervention;handheld mobile device;Health Care Costs;Health Care Sector;health service use;Healthcare;high risk;HIV;HIV Infections;HIV risk;Home;Human immunodeficiency virus test;Incidence;incremental cost;innovation;Intervention;Interview;Knowledge;Laboratories;Letters;Life;Link;Location;Los Angeles;male;marginalization;Mediator;mhealth interventions;mobile application;Modeling;models and simulation;Motivation;National Institute of Mental Health;online delivery;Participant;participant enrollment;Pediatric Hospitals;Persons;pilot test;pilot trial;Population;Populations at Risk;pre-exposure prophylaxis;Prevalence;prevent;Prevention;Prevention strategy;preventive intervention;primary outcome;Procedures;Process;psychosocial;Randomized;Randomized, Controlled Trials;recruit;reproductive;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Risk;Risk Reduction;rural area;Sampling;San Francisco;satisfaction;Screening procedure;secondary outcome;Self Efficacy;self esteem;sex;Sexual Partners;Site;skills;social disparities;social stigma;sociodemographic variables;socioeconomics;standard of care;substance use;Surveys;Technology;Testing;theories;Time;transgender;transgender women;Treatment Efficacy;Universities;Update;uptake;usability;Vagina;web app;Work

PROJECT_TITLE: Digital, Limited Interaction Efficacy Trial of LifeSkills Mobile to Reduce HIV Incidence in Young Transgender Women


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: NEWARK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW JERSEY INSTITUTE OF TECHNOLOGY

ORG_STATE: NJ

PHR: Narrative  Cross-linking mass spectrometry (CLMS), a powerful technique for determining protein conformational structures, lacks capability for absolute quantitation of cross-links (i.e., cross- linked peptides). This proposal aims to develop a novel absolute quantitative cross-linking mass spectrometry (aqCLMS) based on the combination of CLMS with coulometric mass spectrometry (CMS). We also propose to apply aqCLMS, coupled with advanced molecular dynamics (MD) simulation, to study dynamic conformations of PROTAC-mediated ternary complexes for improved accuracy for their structural determination.

PI_NAMEs: CHEN, HAO  (contact);CHENG, XIAOLIN

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Combining Absolute Quantitative Cross-Linking Mass Spectrometry and Molecular Modeling for Probing PROTAC-Mediated Ternary Complex Structures

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Rare Diseases

ORG_CITY: TAMPA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Molecular and cellular mechamisms that regulate the formation and maintenance of vascular lumen, or tubulogenesis, are poorly understood. The proposed study will investigate the functional role of an evolutionarily conserved novel adaptor protein Src homology 2 domain containing E (She) and its interaction with Abelson (Abl) kinase signaling pathway in regulating vascular lumen size in zebrafish embryos and human vascular endothelial cells. We will further explore the potential application of SHE as a tool to normalize vascular lumen size in human venous malformation. The acquired knowledge will promote development of new strategies aimed at treating vascular malformations as well as bioengineering new vessels for regenerative therapies.

PI_NAMEs: SUMANAS, SAULIUS  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adaptor Signaling Protein;Adhesions;Aorta;Biochemical;Biological Assay;Biological Process;Biomedical Engineering;Blood Vessels;Cell Culture Techniques;cell motility;Cell Separation;cell type;Cells;Chemicals;Clinical;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Development;Diameter;Disease;Dorsal;E protein;Embryo;Endothelial Cells;Event;experimental study;Family;fluid flow;Genetic;Growth;Human;human disease;improved;inhibitor;Knowledge acquisition;Lesion;Maintenance;malformation;Modeling;Molecular;Morphogenesis;Mus;mutant;Natural regeneration;novel;novel strategies;novel therapeutic intervention;Organism;overexpression;Pathologic;Patients;Phosphotransferases;Play;Process;Protein Tyrosine Kinase;Proteins;regenerative therapy;repaired;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Testing;Therapeutic;three dimensional cell culture;tool;Tube;vascular bed;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelium;Venous Malformation;Xenograft Model;Xenograft procedure;Zebrafish

PROJECT_TITLE: Role of SHE and ABL signaling in vascular tubulogenesis

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Kidney Disease;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE Protein kinase inhibitors are prominent components in the treatment of cancer and inflammatory diseases. Using unbiased functional genomic screening and unique genetic mouse models, we have found that kinase inhibitor mediated off-target inhibition of heme biosynthesis enzyme ferrochelatase contributes to toxicity in normal tissues. Our proposed studies aim to elucidate the molecular mechanisms that drive kinase inhibitor linked toxicities and could result in identification of potential mitigating strategies, which has high translational significance.

PI_NAMEs: BAJWA, AMANDEEP ;PABLA, NAVJOT  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Albumins;Binding;Binding Sites;Biological Assay;Biology;cancer therapy;Cell Death;Cell Line;Cell Physiology;Cells;chemical genetics;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;conditional knockout;CRISPR screen;Data;Development;Disease;Drug toxicity;Endocytosis;enzyme biosynthesis;Enzymes;Epithelial Cells;FDA approved;Female;ferrochelatase;functional genomics;Gender;gender difference;Genes;Genetic;Genetic Transcription;genome-wide;Heme;heme biosynthesis;Human;human disease;In Vitro;in vivo;Inflammatory;Injury to Kidney;insight;interdisciplinary approach;intrinsic factor-cobalamin receptor;Kidney;kinase inhibitor;knock-down;Knock-in;Knock-out;knockout gene;Knockout Mice;Knowledge;Link;male;Malignant Neoplasms;Mediating;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Molecular;mouse model;Mus;Mutation;nephrotoxicity;Normal Cell;Normal tissue morphology;Oncology;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Actions;Phosphotransferases;Prevalence;Protein Kinase;protein kinase inhibitor;Proteins;Proteomics;Proto-Oncogene Proteins B-raf;Resistance;response;RNA Interference;RNA interference screen;Role;RUNX1 gene;screening;Signal Transduction;Signal Transduction Pathway;small molecule;small molecule therapeutics;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;Toxic effect;transcription factor;transport inhibitor;Tubular formation;tumorigenesis;Up-Regulation;uptake;women versus men;Work

PROJECT_TITLE: Off target mechanisms of kinase inhibitor toxicities

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Organisms adapted to extreme environmental conditions hold natural solutions to many human diseases. The long-term goal of this project is to understand the cellular adaptations sustaining life in the absence of oxygen. This work will lend insight into cellular manipulations that may extend human life during heart attack, stroke, and organ transplantation, as well as in the face of neurodegenerative diseases and diseases associated with mitochondrial mutations.

PI_NAMEs: RIGGS, CLAIRE L (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Anoxia;Automobile Driving;Biogenesis;biological adaptation to stress;Biological Assay;Biology;career development;Career Mobility;Cell model;Cell Physiology;Cell Survival;Cells;Cellular biology;Cellular Stress;Cytoplasm;Data;Disease;Embryo;Environment;Equilibrium;Female;Fishes;Fostering;G3BP1 gene;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;higher education;Hospitals;Human;Human Cell Line;human disease;innovation;insight;Killifishes;Life;medical schools;Membrane;Mentors;Messenger RNA;metabolic depression;MicroRNAs;Mitochondria;Mitochondrial Diseases;Modeling;Mutation;Myocardial Infarction;Neurodegenerative Disorders;novel;novel strategies;novel therapeutics;Nuclear;Organ Transplantation;Organelles;Organism;overexpression;Oxygen;Phase;prevent;programs;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;Regulator Genes;Research;Research Personnel;Resources;response;ribosome profiling;RNA;Scientist;selective expression;sodium arsenite;Stress;stress granule;stress tolerance;stressor;Stroke;Study models;success;Testing;Therapeutic;Training;Transfer RNA;Translational Regulation;Translational Repression;Translations;Untranslated RNA;Up-Regulation;Venezuela;Vertebrates;Woman;Work

PROJECT_TITLE: Stress tolerant annual killifish: a new model for the cellular stress response


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: Project Narrative: Overall Component This application would initiate a Center of Biomedical Research Excellence (COBRE) at Boys Town National Research Hospital in Omaha, Nebraska, with a focus on pediatric neuroscience, developmental neuroimaging, and brain health. The Center for Pediatric Brain Health would include an Administrative Core that oversees a series of integrated support programs, an advanced Neural Quantification & Imaging Core Facility, a Supervisory & Mentoring Committee, four COBRE research project leaders, and an established cohort of senior investigators. The Center would leverage major recent growth in staff and facilities through Boys Town’s pediatric neuroscience initiative, and continue the organization’s mission to change the way America cares for children and families.

PI_NAMEs: WILSON, TONY W (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Acceleration;Advisory Committees;Area;boys;Brain;brain health;career;career development;Centers of Research Excellence;Child;Child Care;Childhood;Cognitive;cohort;Collaborations;collaborative environment;Collection;Communities;Community Health;Community Outreach;Computers and Advanced Instrumentation;Core Facility;Development;Educational workshop;Ensure;Equipment;Evaluation;Event;experience;Extramural Activities;Faculty;Family;Fostering;Funding;Future Generations;Future Teacher;Goals;graduate student;Growth;Health;Home;Hospitals;Human;Image;Imaging technology;improved;Infrastructure;innovation;Institution;instrumentation;Internships;Lead;Magnetic Resonance Imaging;Magnetoencephalography;Mentors;Methods;Mission;Monitor;multidisciplinary;multimodal neuroimaging;National Institute of General Medical Sciences;Nebraska;neural;neuroimaging;neuroregulation;Neurosciences;Neurosciences Research;next generation;novel;outreach;Participant;Pilot Projects;Population;Postdoctoral Fellow;prisma;programs;Publications;Publishing;Registries;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Senior Scientist;Series;Site;square foot;Structure;System;Training;Training and Education;training opportunity;Training Programs;Voice;welfare;Work

PROJECT_TITLE: Center for Pediatric Brain Health


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Pediatric

PROJECT_TERMS: Administrator;Advisory Committees;analytical method;Area;Award;Awareness;behavior test;boys;Brain;brain health;career;career development;Centers of Research Excellence;Child;Childhood;cohesion;Communities;Community Health;Community Outreach;Dedications;Development;Development Plans;Educational workshop;Ensure;Equipment;Evaluation;Event;experience;Extramural Activities;Faculty;Fellowship;Financial Support;Funding;Future;Goals;graduate student;Hospitals;Human;human imaging;Human Resources;Image;Individual;Infrastructure;interest;International;Internships;Investments;Laboratories;Mentors;Mentorship;Monitor;National Institute of General Medical Sciences;neural;neuroimaging;neurophysiology;Neurosciences;Neurosciences Research;next generation;operation;outreach program;Participant;Periodicals;Pilot Projects;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Progress Reports;Publishing;recruit;Registries;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;scaffold;Science;Scientist;Series;Support System;System;Target Populations;Testing;tool;Training;training opportunity;Training Programs;undergraduate student;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Genetics;Neurosciences

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: Project Narrative Understanding human mental health disorders requires a basic understanding of the nervous system. It is critical to understand how neuronal connections are built during development and how neural circuits function in the adult. This study seeks to understand at a molecular-genetic level how the potential for behavior is built into the nervous system. These studies will proceed with analyses in a multi-cellular organism, so we can interrogate the role of genes, proteins and neural circuits in a functionally relevant context to gain insight in how a circuit for a complex behavior is built and functions.

PI_NAMEs: ARBEITMAN, MICHELLE N (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Adult;Behavior;Behavioral;Biological Models;Brain;Complex;Development;Disease;Drosophila genus;experience;Funding;gene function;gene regulatory network;Genes;Genomics;Health;Human;insight;Laboratories;Mental disorders;Mental Health;Microscopy;Modeling;Molecular;Molecular Genetics;Mutation;National Institute of General Medical Sciences;Nervous System;neural circuit;neuron development;Neurons;Organism;Physiology;Process;programs;Proteins;Proteomics;Reproductive Behavior;Research;Role;sex;Structure;System;tool;transcription factor;Work

PROJECT_TITLE: Genes underlying reproductive behavior physiology and neuronal development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PROJECT_TERMS: Adult;advanced system;analytical method;base;Biological;boys;Brain;brain health;brain research;Capital;Centers of Research Excellence;Cephalic;Child;Childhood;Collection;Communities;Community Health;Computer software;computerized data processing;connectome;Core Facility;Data;data acquisition;Data Analyses;Data Analytics;Dedications;Depreciation;Devices;Diffusion;Educational workshop;Engineering;Ensure;Environment;Equipment;experience;Experimental Designs;experimental study;Extramural Activities;Faculty;Fees;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Growth;Head;High Performance Computing;Home;Hospitals;Human;Image;improved;Infant;Infrastructure;Institution;instrument;instrumentation;International;Internships;Laboratories;laboratory experience;Loudness;Magnetic Resonance Imaging;Magnetoencephalography;Magnetometries;Measurement;Measures;Mentors;Methods;mid-career faculty;Mission;Modality;multimodal fusion;multimodal neuroimaging;multimodality;neural;neuroimaging;neurophysiology;neuroregulation;Neurosciences;Neurosciences Research;new technology;novel;Optics;Participant;Performance;Perfusion;Pilot Projects;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;prisma;programs;Protocols documentation;Publications;Publishing;Pump;Research;research and development;Research Infrastructure;Research Project Grants;Research Support;Resolution;Resources;Role;Scientist;Site;spectroscopic imaging;Spectrum Analysis;square foot;Stretching;Structure;success;System;Technical Expertise;Techniques;tool;Training;Training Programs;wearable device;Work

PROJECT_TITLE: Neural Quantification & Imaging Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative Enhancers are regulatory DNA sequences that underly a wide variety of human diseases when misregulated because they determine when and where a target gene will be expressed. Because these sequences are critical for driving proper spaciotemporal target gene expression during development and cellular transitions, they are maintained in an inaccessible and inactive state until the precise context for gene activation is reached. This study aims to characterize how enhancers are made accessible and active by DNA-binding proteins during embryonic development, which will provide mechanistic insight into how cells regulate enhancer activity to control their gene expression programs.

PI_NAMEs: BRENNAN, KAELAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Affect;ATAC-seq;Automobile Driving;base;Binding;Cell Reprogramming;cell type;Cells;Chemicals;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;convolutional neural network;Data;deep learning model;Development;developmental disease;Diabetes Mellitus;Disease;DNA;DNA Sequence;DNA-Binding Proteins;Dorsal;Drosophila genus;Drosophila melanogaster;Embryo;Embryonic Development;Engineering;Enhancers;Excision;experimental study;Exposure to;Face;Gene Activation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genome;genome-wide;genome-wide analysis;Genomic approach;Genomics;Histones;Human body;human disease;in vivo;insight;Malignant Neoplasms;Maps;Mediating;Modeling;mutant;Mutation;next generation sequencing;Nucleosomes;Obesity;Pattern;Pattern Formation;Positioning Attribute;predictive modeling;prevent;programs;Proteins;Regulation;Reporter Genes;Resolution;spatiotemporal;System;Techniques;temporal measurement;Testing;Time;Tissues;transcription factor;Transgenic Organisms;Variant;Work

PROJECT_TITLE: Investigating how transcription factors cooperate and overcome the enhancer nucleosome barrier during embryonic patterning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Effects of Indoor Air Pollution;Neurosciences;Pediatric;Social Determinants of Health

PI_NAMEs: TAYLOR, BRITTANY  (contact)

PROJECT_TERMS: Academic achievement;Address;Adolescent;Adolescent Development;Adult;Affect;Air;Air Pollution;Area;Attention;Awareness;behavior measurement;Brain;brain health;carcinogenesis;carcinogenicity;Cell Physiology;Cells;Child;Child Development;Childhood;Chronic;Cigarette;cigarette smoke;Cognition;Cognitive;cognitive development;cognitive function;cognitive performance;Communities;Country;County;Coupled;Dangerousness;Data;design;Development;dosage;Enrollment;Environment;Environmental Pollutants;Environmental Pollution;Exhibits;Exposure to;Foundations;Functional disorder;Future;Gases;Goals;gray matter;Health;Health Policy;high risk;Home;home test;Immunologics;Incidence;indexing;Industrialization;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;Inhalation;innovation;Investigation;Knowledge;Lead;Link;Magnetic Resonance Imaging;Magnetoencephalography;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Measures;Mediating;Mental Health;multimodal neuroimaging;multimodality;Nebraska;neural;Neurocognitive;neurodevelopment;neuroimaging;neurophysiology;Neuropsychology;Organ;Outcome Study;Pathology;Performance;Persons;Pesticides;Probability;Process;Public Health;Radiation;Radioactive;Radon;Recommendation;Research Priority;Research Project Grants;Risk;Rodent Model;Role;saliva sample;Sampling;Shapes;Smoking;Soil;Source;Stimulus;Structure;System;Techniques;Thick;Tissues;Toxic effect;Toxic Environmental Substances;United States;United States Environmental Protection Agency;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Cognitive, Immunological, and Neurophysiological Consequences of  Home Radon Exposure in Children and Adolescents


NIH_SPENDING_CATS: Cardiovascular;Genetics;Hypertension

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative Blood vessels play an important role in the regulation of arterial blood pressure and precise blood pressure regulation requires coordination between vasodilator and vasoconstrictor signals in the endothelium and smooth muscle. Our data support the concept that PPARγ acts as a sensor in endothelium to regulate redox state, and through this, bioavailability of nitric oxide, and regulates the responsiveness of the smooth muscle to nitric oxide by independently controlling a RhoA/Rho kinase (ROCK) activity that promotes constriction, and production and stability of cyclic GMP (cGMP), a critical mediator of vasodilation. This proposal will delineate a vision for the next seven years of research elucidating molecular and physiological mechanisms controlling vasomotor function, arterial stiffness and BP by PPARγ and Cullin-3.

PI_NAMEs: SIGMUND, CURT DANIEL (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Antioxidants;arterial stiffness;Binding;Biological Availability;Blood Pressure;blood pressure regulation;Blood Vessels;cell type;chromatin immunoprecipitation;cofactor;comorbidity;Complex;constriction;Contracts;cullin-3;Cyclic GMP;Data;Disease;disease model;Endothelium;Future;Genetic Transcription;genome-wide;Hypertension;Investigation;Mediating;Mediator;Modeling;Molecular;Molecular Target;Nitric Oxide;Nitric Oxide Pathway;novel;Nuclear Receptors;Oxidation-Reduction;Pathway interactions;Phenotype;phosphodiesterase V;Physiological;Play;Post-Translational Regulation;PPAR gamma;PPARG gene;pressure;Production;programs;protein degradation;Proteomics;Regulation;Research;response;Retinol Binding Proteins;Rho-associated kinase;Role;RXR;sensor;Signal Transduction;Smooth Muscle;Structure;Therapeutic;transcription factor;transcriptome;ubiquitin-protein ligase;Vascular Diseases;Vascular Smooth Muscle;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents;Vasomotor;Vision

PROJECT_TITLE: PPARG-dependent Mechanisms Control Endothelial-Smooth Muscle Coordination, Arterial Pressure, Vasomotor Function and Arterial Stiffness


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Home for exceptional science and of internationally renowned cancer experts and supported by a comprehensive clinical research infrastructure, the Robert H. Lurie Comprehensive Cancer Center of Northwestern University (LCC) is poised to continue leadership of and participation in Network Group trials as a high performing LAPS. The success of this application will enable expanded participation of LCC members in NCTN trials, scientific leadership of key network activities, increased inter-institutional collaborations, and access to unique scientific resources to advance cancer interventions.

PI_NAMEs: BENSON, AL B (contact);MATEI, DANIELA E

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adult;Advanced Malignant Neoplasm;Advisory Committees;American College of Radiology Imaging Network;Ancillary Study;Basic Science;bench-to-bedside translation;Cancer Center;Cancer Intervention;Cancer Patient;cancer therapy;career;Clinical;clinical care;clinical imaging;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Core Facility;Core Grant;data quality;data repository;design;Development;Discipline;Disease;Eastern Cooperative Oncology Group;Enrollment;Ensure;experience;Faculty;Financial Support;follow-up;Goals;Group Affiliation;Health;Home;Image;image archival system;imaging modality;improved;Infrastructure;Institution;inter-institutional;International;Intervention Studies;Intervention Trial;Investments;Laboratories;Lead;Leadership;Malignant Neoplasms;medical schools;member;Mentors;Mentorship;multimodality;Organization administrative structures;Outcome;Outcome Measure;Pathology;Patients;Phase;Population Sciences;Productivity;programs;Publications;quantitative imaging;Rare Diseases;Recording of previous events;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Resource Sharing;Resources;Role;Science;Scientific Advances and Accomplishments;senior faculty;Site;Southwest Oncology Group;Special Population;standard of care;Structure;success;Time;Tissue Banks;tissue resource;Tissues;Universities;Validation

PROJECT_TITLE: Northwestern University Lead Academic Participating Site


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Donor organ shortage in transplantation can be greatly mitigated by a clear mechanistic understanding of early allograft inflammation that restricts our ability to utilize donor kidneys with prolonged cold ischemia and our ability to effectively induce transplant tolerance. Our preliminary studies suggest that the donor kidney resident macrophage population is a critical mediator of this process. The overall goal of this proposal is to mechanistically define the role of donor kidney resident macrophages in this process, and to design clinically feasible therapies targeting this population for enhancing short-term kidney allograft function and long-term kidney allograft survival.

PI_NAMEs: LUO, XUNRONG  (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute;Alloantigen;Allogenic;Allografting;CCL8 gene;Cells;chemokine;Clinical;design;Effector Cell;efficacy testing;End stage renal failure;Equilibrium;experience;Fluorescence;Genes;Goals;Graft Rejection;imaging study;Immune;Immune Tolerance;Immunity;Immunobiology;Immunologics;Immunosuppression;Infiltration;Inflammation;Inflammatory Response;innovation;insight;Intervention;Intestines;intravital microscopy;Ischemia;isoimmunity;Kidney;kidney allograft;kidney imaging;Kidney Transplantation;Knowledge;Label;Lung;Macrophage;Mediating;Mediator;multi-photon;Mus;Myeloid-derived suppressor cells;Organ;Organ Donor;Play;Population;post-transplant;prevent;Process;Production;Proliferating;Reactive Oxygen Species;recruit;Regimen;Regulatory T-Lymphocyte;Reperfusion Injury;Research Personnel;Resistance;response;Role;serial imaging;Shapes;Signal Transduction;single-cell RNA sequencing;Solid;Suppressor-Effector T-Lymphocytes;T-Lymphocyte;Target Populations;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;Tissue imaging;Tissues;transcriptomics;transplant model;Transplant Recipients;Transplantation;Transplantation Tolerance

PROJECT_TITLE: Donor Kidney Resident Macrophages in Kidney Allograft Early Inflammation and Alloimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Mental Health;Neurosciences;Pediatric

PI_NAMEs: DOUCET, GAELLE EVE (contact)

PROJECT_TERMS: Adolescence;Adolescent;Adolescent and Young Adult;adolescent brain development;Adolescent Development;Adult;Age;age effect;age related changes;aged;Behavior;Behavior assessment;behavior measurement;Behavioral;Brain;brain health;Brain Mapping;Childhood;Chronology;Cognition;Cognitive;cognitive ability;cognitive task;cognitive testing;connectome;Control Groups;critical period;Data;Development;Diagnosis;early adolescence;Emotional;Exhibits;Family history of;Foundations;Functional Magnetic Resonance Imaging;high risk;Image;imaging study;improved;Incidence;Individual;Link;Literature;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Mental Health;multimodality;Multivariate Analysis;network architecture;neural;Outcome;Participant;Phase Transition;Play;prisma;Protocols documentation;Psychopathology;Puberty;Research Project Grants;Resolution;Rest;Risk;Role;Sampling;segregation;spatial integration;Structure;Testing;trait;transition to adulthood;Work;young adult

PROJECT_TITLE: Developmental changes in the reconfiguration of brain networks and their association with psychiatric traits during adolescence


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Hematology;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE Glioblastoma is the most common and aggressive primary brain tumor in adult which is defined by a hypoxic niche that drives resistance to therapies and promotes tumor growth. Our data indicates this niche is fueled by creatine delivered by infiltrating immune cells. In this proposal we seek to understand the role of creatine in promoting GBM growth and if creatine metabolic inhibition is a useful strategy by which we can hinder GBM growth and recurrence.

PI_NAMEs: MISKA, JASON  (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: Ablation;Adult;Anabolism;Antitumor Response;Biological;Blood - brain barrier anatomy;Blood coagulation;Blood Vessels;Brain Neoplasms;Cell Hypoxia;Cell Separation;Cell Survival;Cells;Cellular Structures;Central Nervous System;Chemicals;Chemoresistance;chemotherapy;Chemotherapy and/or radiation;clinical application;clinical development;clinically relevant;Communication;Creatine;creatine transporter;Data;Disease;Disease Progression;Environment;Enzymes;Event;Exhibits;experimental study;extracellular;fitness;Generations;Genes;Genetic;Genetic Models;Glioblastoma;Glioma;Glycine;Growth;Histologic;Histopathology;Human;human model;Hyperplasia;Hypoxia;immune cell infiltrate;Infiltration;inhibitor;Lesion;Maintenance;Malignant Neoplasms;Metabolic;metabolic phenotype;Metabolic stress;Metabolism;Modality;Modeling;mouse model;multiple omics;Mus;Myelogenous;Myeloid Cells;Necrosis;neoplastic cell;Pathogenesis;Pathologic;Pathway interactions;patient derived xenograft model;patient screening;Patients;pharmacologic;Phenotype;Primary Brain Neoplasms;Primary Neoplasm;Production;Pseudopalisading Necrosis;radiation resistance;Radiation therapy;Recurrence;Research;Resistance;Role;Sampling;single-cell RNA sequencing;Source;stem cell biology;stem cells;stemness;Stress;Structure;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Thrombosis;transcriptomics;treatment strategy;Tropism;tumor;tumor growth;tumor hypoxia;Tumor Markers;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;uptake;Work

PROJECT_TITLE: The hypoxic niche in glioblastoma is maintained by myeloid produced creatine

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Hearing Loss;Mental Health;Neurosciences;Pediatric;Rehabilitation

PI_NAMEs: HEINRICHS-GRAHAM, ELIZABETH  (contact)

PROJECT_TERMS: 14 year old;Affect;age related;Area;Attention;Auditory;Behavior;behavior test;Behavioral;behavioral outcome;Brain;brain health;Child;Childhood;Clinical;Cochlear Implants;Cognition;Cognitive;cognitive ability;cognitive control;Cognitive deficits;cognitive development;cognitive function;cognitive performance;cognitive skill;cognitive task;cognitive testing;cohort;comparison group;Complex;Data;Development;Dorsal;dosage;Dose;Enrollment;executive function;Exhibits;experience;falls;Goals;hard of hearing;Hearing;Hearing Aids;hearing impairment;Hearing Tests;Heterogeneity;imaging approach;Improve Access;indexing;Individual Differences;innovation;Intervention;Investigation;Language;Language Delays;Language Development;language processing;Language Tests;Learning;Link;Magnetic Resonance Imaging;Magnetoencephalography;Matched Group;Measures;Mediating;Memory;Methods;Multimodal Imaging;multimodality;neural;neurodevelopment;neuroimaging;neuromechanism;Neurons;neurophysiology;Neurophysiology - biologic function;Neuropsychological Tests;non-verbal;normal hearing;Outcome;Parietal;Pattern;peer;Performance;personalized therapeutic;Physiological;Physiology;Population;Research Project Grants;response;Risk;Severities;Short-Term Memory;Speech;Time;verbal;Work

PROJECT_TITLE: Characterizing the Impact of Auditory Experience on Language, Cognitive, and Neural Development in Children


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Clinical Research;Genetic Testing;Genetics;Human Genome;Prevention;Skin Cancer

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Keratinocyte carcinoma afflicts approximately 3 million Americans annually, and its treatment is among the costliest of all cancers. Keratinocyte carcinomas derive from epidermal keratinocytes, but diverge along two distinct oncogenic pathways, giving rise to two distinct phenotypic tumors, basal cell carcinoma and squamous cell carcinoma. This project will identify genetic loci that affect the risk of keratinocyte carcinoma, examine how environmental risk factors influence genetic risk, and determine whether these loci act to influence the risk of basal cell carcinoma, squamous cell carcinoma, or both.

PI_NAMEs: ASGARI, MARYAM MANDANA;CHOQUET, HELENE  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Actinic keratosis;Adult;Affect;Age;Aging;American;Basal cell carcinoma;Behavior Therapy;biobank;Biological Process;cell type;Cells;Chronic;Classification;Clinical;clinical effect;Clinical Markers;Code;cohort;cost;Data;Development;Diagnosis;Disease;Environmental Exposure;Environmental Risk Factor;Etiology;experience;Genetic;genetic association;genetic epidemiology;genetic resource;Genetic Risk;genetic risk factor;Genetic study;genetic variant;genome-wide;genomic locus;Health;Heritability;high risk;Histologic;Immunosuppression;improved;in silico;Individual;innovation;insight;Invaded;keratinocyte;Light;Malignant Epithelial Cell;Malignant Neoplasms;Modification;neoplasm registry;never smoker;non-genetic;Oncogenic;Participant;Pathogenesis;Pathway interactions;perineural;Phenotype;Physicians;Pigmentation physiologic function;predictive modeling;predictive tools;Predisposition;Prevention;Probability;Recording of previous events;Records;Recurrence;Registries;Risk;Risk Factors;risk prediction;risk prediction model;risk sharing;risk variant;Role;screening;Screening for cancer;sex;sex variable;Skin Carcinoma;Smoker;Smoking;Smoking Behavior;Squamous cell carcinoma;Subgroup;Sun Exposure;tool;tumor;Tumor Burden;Ultraviolet Rays;United States;UV Radiation Exposure;Work

PROJECT_TITLE: The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility