NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Pediatric

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Project narrative Although research has suggested a link between social media use and symptoms of “internalizing” disorders like depression or anxiety, in the United States almost all adolescents 13-20 years old use a social media platform and roughly half use social media “constantly.” Not all youth who use social media experience harmful effects so in order to develop interventions that promote adaptive social media use, it is important to understand what ways of using social media are harmful and who is most harmed by them. This study aims to collect longitudinal self-report of mental health along with text data from adolescents’ smartphones to study the relationship between the language adolescents use on social media use and their risk for internalizing symptoms.

PI_NAMEs: BOLLEN, JOHAN L.;LORENZO LUACES, LORENZO  (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 20 year old;21 year old;Adolescent;Adult;Affect;Age;Age Years;aged;Anxiety;associated symptom;Cellular Phone;Cognitive;Cognitive Therapy;cohort;comorbidity;contagion;Data;Data Reporting;Depressed mood;Diagnostic;Disease;Ecological momentary assessment;Equation;Exhibits;experience;Feedback;Future;Health;Health Status;Impairment;improved;Individual;Individual Differences;Internet;Intervention;Language;Lesbian Gay Bisexual Transgender Queer;lexical;life span;Link;Longitudinal Studies;media use;Mental Depression;Mental Health;Meta-Analysis;Metadata;minority children;Minority Groups;Modeling;Moods;natural language;Natural Language Processing;Nature;Participant;Patient Self-Report;Predisposition;psychiatric symptom;Psychopathology;Research;Risk;Sampling;Severities;Shapes;social;social media;social observations;sociodemographics;suicidal;Symptoms;systems research;Testing;Text;theories;Thinking;United States;Work;Youth

PROJECT_TITLE: #EverythingSucks: Understanding the bidirectional relations between vulnerability to internalizing symptoms in youth (13-20) and social mediacontent


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: CLEVELAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: RUSTBELT CFAR Developmental Core B Revision San Juan, the capital of Puerto Rico, is a Phase 1 Priority Jurisdiction identified in the Ending the HIV Epidemic (EHE). Greater diversity in the healthcare and research workforce is an  important strategy to address racial and ethnic healthcare disparities. The Rustbelt CFAR is has  developed education and training pathways for Puerto Rican students to become scientists or physician-scientists engaged in HIV/AIDS.

PI_NAMEs: HILLIER, SHARON L.;KARN, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acculturation;Acquired Immunodeficiency Syndrome;Address;Adult;Affect;AIDS prevention;apprenticeship;Automobile Driving;base;Basic Science;Bioinformatics;Biological Assay;Biostatistics Core;Brain Drains;Capital;career;Centers for Disease Control and Prevention (U.S.);Charge;Clinical;Clinical Research;Clinical Sciences;cohort;community engagement;Community Outreach;County;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Education;education research;Employment;Enrollment;Epidemic;Ethnic Origin;Evaluation;expectation;experience;Foundations;Funding;Gender;Goals;graduate school;graduate school preparation;graduate student;health care disparity;Healthcare;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;Individual;innovation;Institution;International;Island;Knowledge;Laboratories;Latinx;Latinx population;Leadership;lifetime risk;Medical;member;men who have sex with men;Mentors;Modeling;Monitor;multidisciplinary;novel strategies;Occupations;Pathway interactions;Persons;Phase;Physicians;Policies;Population;Positioning Attribute;Postbaccalaureate;pre-exposure prophylaxis;pressure;Prevalence;Prevention Research;Program Reviews;programs;Puerto Rican;Puerto Rico;Race;Recommendation;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Research Training;Science;Scientist;Services;sex;sexual minority men;skills;Specimen;Standardization;student participation;Students;Surveys;synergism;System;Systems Biology;Teacher Professional Development;Technology;Time;Tissue Microarray;Training and Education;Training Programs;Translational Research;Uganda;undergraduate student;United States;United States National Institutes of Health;Universities;University Hospitals;uptake;Viral Pathogenesis;working group

PROJECT_TITLE: Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SA-A (S1)]


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Social Determinants of Health

PI_NAMEs: LEVINE, ALAN DAVID (contact)

PROJECT_TERMS: Acculturation;Acquired Immunodeficiency Syndrome;Address;Adult;Affect;apprenticeship;Attitude;Automobile Driving;Brain Drains;Capital;career;career development;Centers for Disease Control and Prevention (U.S.);Charge;Core Facility;design;Development;Diagnosis;Doctor of Philosophy;doctoral student;Education;education research;Employment;Enrollment;Epidemic;equity, diversity, and inclusion;Ethnic Origin;Evaluation;expectation;experience;Faculty;Funding;Goals;graduate school;graduate school preparation;graduate student;health care disparity;Healthcare;Hispanic;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;Individual;innovation;Island;Knowledge;Laboratories;laboratory facility;Latinx;Latinx population;lifetime risk;Medical;men who have sex with men;Mentors;Modeling;Monitor;next generation;Occupations;Pathway interactions;Persons;Phase;Physicians;Policies;Population;Postbaccalaureate;pre-exposure prophylaxis;pressure;Prevalence;Program Reviews;programs;Puerto Rican;Puerto Rico;Race;Recommendation;recruit;Reporting;Research;Research Personnel;Research Training;response;Science;Scientist;sexual minority men;skills;Standardization;student participation;Student recruitment;Students;Surveys;System;Techniques;Time;Training;Training and Education;Training Programs;undergraduate student;United States;United States National Institutes of Health;Universities;university student;uptake

PROJECT_TITLE: Core B: Developmental


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project narrative This project focuses on understanding how the orbitofrontal cortex and caudate nucleus interact during decision- making, and how high-level cognitive processes might inhibit simpler automatic responses. Dysfunction of both these brain areas has been implicated in a wide variety of neuropsychiatric disorders, including obsessive- compulsive disorder and addiction. Understanding how this pathway works is important for the design of future therapeutic interventions.

PI_NAMEs: WALLIS, JONI D (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: addiction;Adopted;Affect;Alcoholism;Animals;Area;Artificial Arm;Association Learning;Behavior;Behavioral;Brain;brain machine interface;Brain region;caudate nucleus;Chronic;Clinical Trials;cognitive process;Communication;Complex;Compulsive Behavior;Computers;Corpus striatum structure;Data;Decision Making;Decision Theory;Deep Brain Stimulation;design;Devices;Disease;Eating Disorders;electrical microstimulation;Ensure;frontal lobe;Functional disorder;Future;Goals;Grant;Hippocampus;Human;Impairment;Intervention;Learning;Link;Maps;Mediating;Methods;microstimulation;Mood Disorders;Motor;Movement;Movement Disorders;Neurons;neurophysiology;neuropsychiatric disorder;neuropsychiatry;Neurosciences;novel;Obesity;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Outcome;Pathway interactions;Pattern;Pharmacologic Substance;Phase;Population;prevent;Primates;Process;Psychophysics;Research;Resolution;response;Rewards;Rodent;Rodent Model;Role;Saccades;Sampling;sensory cortex;Structure;success;Testing;Therapeutic Intervention;Time;Work

PROJECT_TITLE: Frontostriatal Dynamics During Decision-Making

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Columbus

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE: Cardiac fibrosis is associated with adverse cardiac outcomes, and is regulated by the activation of quiescent cardiac fibroblasts to myofibroblasts. The long-term objective of the study is to understand how the RNA- binding protein HuR regulates the function of cardiac fibroblasts. Specifically, this project will determine how HuR signaling and its downstream target Wisp1 affects cardiac function, morphology, and compliance; and whether we can manipulate HuR or Wisp1 signaling to reverse cardiac fibrosis in the diseased heart.

PI_NAMEs: KANISICAK, ONUR ;TRANTER, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Affect;Antigens;aorta constriction;Binding;Cardiac;Cardiac Myocytes;cell type;Cells;connective tissue growth factor;Consensus;coronary fibrosis;Data;Extracellular Matrix;Fibroblasts;Gene Expression;Genetic;Goals;Heart;Heart Diseases;Heart failure;heart function;heart preservation;Human;In Vitro;in vivo;Individual;knock-down;loss of function;mechanical properties;Mechanics;Mediating;Mediator;Morphology;mouse model;Mus;Myocardial;Myocardium;Myofibroblast;Outcome;overexpression;Paracrine Communication;Pathologic;Pathway interactions;periostin;pharmacologic;Phenotype;Play;Population;pressure;Proteomics;Recombinants;response to injury;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Therapeutic;translational impact;Untranslated RNA;Variant;Work

PROJECT_TITLE: Functional and mechanistic delineation of HuR-Wisp1 signaling on myofibroblast activity

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


PHR: PROJECT NARRATIVE: Obesity is a preventable chronic condition that affects nearly 1 in 3 Americans and can lead to other serious diseases such as type II diabetes, stroke, and cardiovascular disease. However, adipose tissue has many roles other than just to store excess lipids. In this project, we will study how the Human antigen R protein can affect the ability of adipose tissue to (1) increase energy expenditure through the generation of heat, and (2) directly impact the development of cardiovascular disease through remote signaling originating from adipose tissue.

PI_NAMEs: TRANTER, MICHAEL  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Agents;Affect;American;Antigens;Binding;Brown Fat;Calcium;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cell type;Chronic;Clinical;comorbidity;coronary fibrosis;Cytoplasm;Data;Development;Diabetes Mellitus;Disease;Dyslipidemias;Endocrine;Endocrine Glands;Endoplasmic Reticulum;Energy Metabolism;extracellular vesicles;Gene Expression;Generations;Genes;Genetic;Goals;heart function;Heart Hypertrophy;Homeostasis;Human;HuR protein;in vivo;inducible Cre;innovation;knock-down;Laboratories;Link;Lipids;Location;Mediating;Mediator;Messenger RNA;Metabolic;Metabolism;mouse model;Mus;Muscle Cells;Myocardial;Myocardium;Neonatal;Non-Insulin-Dependent Diabetes Mellitus;novel;Obese Mice;obese person;Obesity;overexpression;Pathology;Pathway interactions;pharmacologic;Physiology;Post-Transcriptional Regulation;Proteins;Publications;Publishing;Rattus;Regulation;RNA;RNA-Binding Proteins;Role;RyR2;Signal Transduction;Stroke;subcutaneous;Thermogenesis;Tissue Sample;Ventricular;vesicle transport;Visceral;Work

PROJECT_TITLE: Post-transcriptional control of adipose tissue gene expression as an endocrine mediator of cardiac pathology

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PI_NAMEs: CORTES CIRIANO, ISIDRO  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Africa;African;African ancestry;anti-cancer research;Benchmarking;biobank;Bioinformatics;Biological;Biological Factors;Biopsy Specimen;black patient;cancer genome;cancer health disparity;Characteristics;Chromosome Mapping;clinically relevant;cloud based;cohort;Collaborations;Complex;computer framework;Data;Data Element;data repository;Databases;Dedications;early onset;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;Equity;experimental study;Feedback;Genetic;Genetic study;Genetic Variation;Genome;genome analysis;genome sequencing;Genomics;Geography;Germ Lines;Germ-Line Mutation;human pangenome;human reference genome;Immune;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inequity;innovation;Intervention;Letters;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methodology;Methods;Molecular;nanopore;novel;outcome disparities;pan-genome;Participant;Patient advocacy;Patient Self-Report;Patients;Phenotype;Plasma;Policies;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;racism;recruit;reference genome;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;sequencing platform;Shotguns;single molecule;Site;social;social determinants;Somatic Mutation;study population;Surveys;sustainability framework;Technology;tool;transcriptome sequencing;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;United Kingdom;United States;Variant;Vertebral column;virtual;whole genome;Work;working group

PROJECT_TITLE: SAMBAI: SOCIETAL, ANCESTRY, MOLECULAR AND BIOLOGICAL ANALYSES OF INEQUALITIES (CGC)


PHR: Project Narrative The RUSTBELT Center for AIDS Research (CFAR) merges Case-Western University and the University of Pittsburgh to create a regional center focused on the full spectrum of HIV research with a funded research base of over . The “RUSTBELT CFAR Ugandan Faculty Development Program” will engage the infrastructure and outstanding laboratory facilities available through the RUSTBELT CFAR, to provide support and mentorship for Ugandan investigators returning to the country and enhance the diversity of the HIV research community.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa South of the Sahara;AIDS prevention;Anti-viral Agents;Applications Grants;Appointment;Area;Award;base;Biological Assay;Biostatistics Core;career;career development;Chronic;Clinical;Clinical Investigator;Clinical Research;Clinical Services;Clinical Trials;Clinical Virology;co-infection;Collaborations;Communities;Consequences of HIV;Country;Dedications;Development;Dimensions;DNA Methylation;Doctor of Medicine;Drug resistance;Emerging Technologies;Ensure;Epidemic;equipment acquisition;experience;Exposure to;Faculty;faculty mentor;faculty support;forging;Fostering;Funding;Funding Opportunities;Grant;HIV;HIV Infections;Human Resources;Immunology;Infrastructure;insight;Institution;interest;International;Investments;Joints;Laboratories;laboratory facility;Laboratory Research;low and middle-income countries;Maintenance;Marriage;Medical Education;Medical Research;Mentors;Mentorship;Midwestern United States;next generation;Participant;Pathogenesis;Persons;Positioning Attribute;Productivity;Program Development;programs;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;response;Running;Sampling;Scientist;Sex Differences;skills;Somatic Mutation;Specimen;Structure;Systems Biology;Talents;Teacher Professional Development;Technology Transfer;tool;Training;transcriptome;translational scientist;translational study;Uganda;United States National Institutes of Health;Universities;Viral Pathogenesis;virology;Visit;Wages


PI_NAMEs: NANKYA, IMMACULATE LILLIAN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Agreement;AIDS prevention;Applications Grants;Appointment;Award;Biostatistics Core;career development;Chronic;Clinical;clinical center;Clinical Investigator;Clinical Research;clinical research site;Clinical Services;Clinical Trials Unit;co-infection;Collaborations;comorbidity;Conduct Clinical Trials;Country;design;Dimensions;Doctor of Philosophy;doctoral student;Emerging Technologies;equipment acquisition;experience;Faculty;faculty mentor;faculty support;Fostering;Funding;Future;Grant;Health Professional;HIV;HIV drug resistance;Hospitals;Immunology;Infrastructure;insight;Institution;International;International AIDS;International Cooperation;Investments;Joints;Laboratories;laboratory facility;low and middle-income countries;Maintenance;Medical Education;Medical Research;meetings;member;Mentors;Mentorship;Microbiology;Modeling;Modernization;Monitor;next generation;operation;Participant;Pathogenesis;Positioning Attribute;Program Development;programs;recruit;Research;Research Personnel;Resources;Sampling;Scientist;Sex Differences;Specific qualifier value;Specimen;Structure;Students;Systems Biology;Talents;Teacher Professional Development;Technology;Technology Transfer;Training;transcriptome;translational scientist;translational study;Travel;Uganda;United States National Institutes of Health;Universities;Viral Pathogenesis;Visit;Wages;Writing

PROJECT_TITLE: Core C Uganda


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: GERMAN CANCER RESEARCH CENTER

PI_NAMEs: PFISTER, STEFAN  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Advocacy;age group;Alveolar Soft Part Sarcoma;Animals;Area;aspirate;Binding;Biological;Biological Models;Biology;biomarker development;Brain;Brain Neoplasms;Bromodomains and extra-terminal domain inhibitor;Cancer Center;Cell Line;Cells;Chemicals;Chemistry;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor T cells;Clinical;clinical implementation;Clinical Trials;Collaborations;Combined Modality Therapy;Communication;Communities;Coupled;CRISPR screen;CRISPR/Cas technology;Data;Data Set;Decision Making;Dedications;Dependence;Desmoplastic Small Round Cell Tumor;Development;Disease;Dose;drug development;drug discovery;Drug Targeting;drug testing;early phase clinical trial;efficacy study;Elements;Ependymoma;Equilibrium;Evaluation;Ewings sarcoma;experimental study;Genetic;Genetic Transcription;Glioma;Glues;Goals;head-to-head comparison;high risk;Immunocompetent;improved;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;innovation;insight;Intervention;Knowledge;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;Modeling;Molecular;mortality;mouse model;Mus;mutant;MYCN gene;Neuroblastoma;novel;novel strategies;Oncogenes;Oncogenic;Oncoproteins;Outcome;patient derived xenograft model;patient engagement;Patient Participation;Patient Representative;Patients;pediatric drug development;Pediatric Neoplasm;Pediatric Oncology;pediatric patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;pre-clinical;preclinical evaluation;Preclinical Testing;Process;Property;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;prototype;RELA gene;Reporter;Research;Research Personnel;Resistance;resistance mechanism;response biomarker;Risk;Running;Sarcoma;Scientist;screening;selective expression;small molecule;small molecule inhibitor;Solid Neoplasm;structural biology;success;Survival Rate;synovial sarcoma;System;Testing;Therapeutic;Time;Tissues;Toxic effect;trial design;tumor;Tumor Biology;ubiquitin-protein ligase;Validation;wasting;Work;Young driver

PROJECT_TITLE: PROTECT - Harnessing PROTEin Degradation for Advanced Childhood Tumours


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: TEAM SCIENCE – PROJECT NARRATIVE The ultimate purpose of the COBRE in Stroke Recovery is to improve the recovery of those who have suffered a stroke such that long-term quality of life is improved. Our COBRE is uniquely poised to address serious health deficits faced by SC and other IDeA states through a team science effort to develop novel tele-interventions designed to produce lasting functional improvements in the home setting – especially those in rural communities and for those without reliable access to rehabilitation care.

PI_NAMEs: KAUTZ, STEVEN A. (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acute;Address;Adherence;Administrative Supplement;Adult;Affect;African American population;Age;Aging;arm;Behavior Therapy;Behavioral;care seeking;Caring;Centers of Research Excellence;Charge;Chronic;Chronic Care;Clinic;Cognitive;Cognitive deficits;college;County;Data Scientist;Death Rate;Dedications;Development;Device or Instrument Development;disability;disability burden;Discipline;Disparity;Ecological momentary assessment;Effectiveness;Effectiveness of Interventions;Employment;Engineering;Ensure;Environment;Exercise;exercise program;exercise rehabilitation;feasibility testing;functional gain;functional improvement;Funding;Future;Goals;Health;Health Care Costs;Healthcare;Home;Home environment;home test;Hospitalization;Impairment;improved;Individual;Infrastructure;innovation;interdisciplinary approach;Interdisciplinary Study;Intervention;Investments;Learning;Measures;medically underserved;Medically Underserved Area;Methods;Minority Groups;Monitor;mortality;motor deficit;motor recovery;Movement;multidisciplinary;Nerve;Neuronal Plasticity;neuroregulation;novel;Occupational Therapist;Outcome;Performance;Persons;Population;post stroke;primary care provider;programs;Psychologist;psychosocial;Qualifying;Quality of life;Recovery;Recreation;Rehabilitation Outcome;Rehabilitation therapy;rehabilitative care;Research;Research Personnel;Research Project Grants;Resources;Rural;rural area;Rural Community;Rural Population;safety testing;Science;Scientist;Self Administration;Self Care;sensor;skills;South Carolina;Stroke;Stroke Belt;stroke incidence;stroke recovery;stroke rehabilitation;stroke survivor;synergism;System;Techniques;telerehabilitation;Testing;therapy design;tool;Transcend;Translating;Translations;underserved community;Underserved Population;Uninsured;United States Health Resources and Services Administration;Upper Extremity;US State;Vision;Work

PROJECT_TITLE: COBRE in Stroke Recovery Administrative Supplement - Team Science


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: MILWAUKEE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Narrative Transgender and nonbinary (TGNB) youth are at far greater risk for suicide than their cisgender peers, and past research suggested that social media use may increase this risk. This person-centered, longitudinal study will use an adapted digital Photovoice method to better understand the relationship between social media consumption and suicidality. TGNB adolescents (ages 15-20) will use an app to take screenshots of emotionally charged social media content and label them with specific emotions; we analyze the data to understand the the relationship between social media consumption and suicidality.

PI_NAMEs: NAMBISAN, PRIYA  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 20 year old;Address;Adolescent;Advertisements;Age;Area;Artificial Intelligence;bullying;Charge;cisgender;cloud platform;community based participatory research;Complex;Consumption;Data;design;digital;emerging adult;Emotional;emotional reaction;Emotions;experience;Feeds;Feeling suicidal;Fostering;Gender;gender minority;gender minority youth;Goals;harassment;Health Promotion;high risk;High School Student;Image;Individual;interest;Interview;Label;Link;Loneliness;Longitudinal Studies;Maps;marginalization;media use;Mental Depression;Mental Health;Methods;Minority Groups;National Institute of Mental Health;nonbinary;Parents;Participant;Patient Recruitments;Pattern;peer;person centered;Persons;Population;predictive modeling;prevent;Prevention Research;prospective;Public Health;Reaction;recruit;reducing suicide;Research;Research Methodology;Research Subjects;Resources;Risk;Secure;Self-Injurious Behavior;social;social group;social media;suicidal;suicidal risk;Suicide;Suicide prevention;suicide rate;Teenagers;Testing;Time;transgender;Underrepresented Populations;Vulnerable Populations;Youth

PROJECT_TITLE: Using digital photovoice to explore the relationships between social media content and suicidality among transgender adolescents

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (05)]


NIH_SPENDING_CATS: Digestive Diseases;Immunization;Immunotherapy;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE We previously reported that type I interferon signaling induced in response to the asymptomatic liver stages of malaria parasite infection compromise protective adaptive immunity by inducing dysfunctional hepatic memory CD8 T cells. Using infection of the liver by malaria parasites as a model for hepatotropic infection, this application seeks to characterize malaria-induced hepatic CD8 T cell dysfunction to determine how hepatocyte-intrinsic type I interferon signaling reshapes hepatocyte transcriptomes and metabolomes to impair hepatic T cell immunity. Observations from this work will guide the development of highly efficacious liver directed anti-malaria vaccines.

PI_NAMEs: MINKAH, NANA KWAKU (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: adaptive immunity;antagonist;Anti-malarials;Benign;Biological Assay;Biological Models;CD8-Positive T-Lymphocytes;Cells;Cessation of life;chronic infection;Clinical;Complex;Development;dietary;Equilibrium;Erythrocytes;exhaustion;Focal Infection;Functional disorder;Gene Expression Profiling;Hepatic;Hepatocyte;Human;Immune;immune activation;Immune response;Immunity;Immunologics;Impairment;improved;Infection;Innate Immune Response;Interferon Type I;Interferons;IRF3 gene;Liver;Liver diseases;liver function;liver infection;Maintenance;Malaria;Malaria Vaccines;Memory;metabolome;microorganism antigen;Modeling;multiple omics;Mus;Myeloid Cells;novel;Parasites;Parasitic infection;pathogen;Pathway interactions;Plasmodium;Plasmodium falciparum;Primary carcinoma of the liver cells;programs;Reporting;response;Rodent;Role;Shapes;Signal Induction;Signal Transduction;T cell response;T-Lymphocyte;Tissues;transcription factor;transcriptome;Transgenic Organisms;tumor;tumor-immune system interactions;Viral;Work

PROJECT_TITLE: Identifying roles for hepatic myeloid cells in the induction and maintenance of anti-Plasmodium liver-resident memory CD8 T cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: IMIELINSKI, MARCIN  (contact)

PROJECT_TERMS: Address;Africa;African;African ancestry;anti-cancer research;Benchmarking;biobank;Bioinformatics;Biological;Biological Factors;Biopsy Specimen;black patient;cancer genome;cancer health disparity;Characteristics;Chromosome Mapping;clinically relevant;cloud based;cohort;Collaborations;Complex;computer framework;Data;Data Element;data repository;Databases;Dedications;early onset;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;Equity;experimental study;Feedback;Genetic;Genetic study;Genetic Variation;Genome;genome analysis;genome sequencing;Genomics;Geography;Germ Lines;Germ-Line Mutation;human pangenome;human reference genome;Immune;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;Inequality;Inequity;innovation;Intervention;Letters;Link;Lived experience;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;marginalized population;Mass Spectrum Analysis;Measurement;Measures;medical schools;member;Methodology;Methods;Molecular;Molecular Biology;nanopore;novel;outcome disparities;pan-genome;Participant;Patient advocacy;Patient Self-Report;Patients;Phenotype;Plasma;Policies;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;racism;recruit;reference genome;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;sequencing platform;Shotguns;single molecule;Site;social;social determinants;Somatic Mutation;study population;Surveys;sustainability framework;Technology;tool;transcriptome sequencing;transcriptomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;United Kingdom;United States;Variant;Vertebral column;virtual;whole genome;Work;working group

PROJECT_TITLE: SAMBAI: Societal, Ancestry and Molecular Biology Analyses of Inequalities


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Hexanucleotide GGGGCC repeat expansion in the C9ORF72 gene is the most frequent cause of two neurodegenerative diseases, Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). Disease mechanisms include loss of C9orf72 function and gain of toxicity from the repeat containing RNAs. This project will determine cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALS.

PI_NAMEs: JIANG, JIE  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Ablation;Address;age related;Alzheimer's Disease;Antisense Oligonucleotides;Astrocytes;Autopsy;Bacterial Artificial Chromosomes;Behavioral;Biological Assay;C9ORF72;Cause of Death;cell type;Cells;Central Nervous System;Cervical lymph node group;Clinical;Coculture Techniques;Data;Dipeptides;Disease;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Funding;gain of function;Gene Modified;Genes;Genetic;Genetic Transcription;genome-wide;Grant;Human;Immune;Immune response;Immune system;Immunologic Stimulation;Introns;Knockout Mice;loss of function;LoxP-flanked allele;Macrophage;Mediating;Microglia;Modeling;Molecular;Mus;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neurotoxicity;Oligodendroglia;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Play;Production;protein function;Proteins;RNA;RNA-Binding Proteins;Role;Sampling;Signal Transduction;Site;Splenomegaly;Synapses;synergism;Testing;Therapeutic Intervention;tool;Toxic effect;transcriptome;transcriptome sequencing;Transgenic Mice;Translations;United States National Institutes of Health;Untranslated RNA;Vertebral column;Work

PROJECT_TITLE: Cell-type-specific toxicity of C9orf72 repeat expansions in FTD and ALS

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-R]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Obesity;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PI_NAMEs: YILMAZ, OMER  (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Acute;Address;adenoma;Adenomatous Polyps;Age;age effect;Aging;airway epithelium;Alcohols;Allergic;Amplifiers;Animal Model;anti-cancer research;Biological;Biological Factors;Biological Models;Birth;Body Weight decreased;cancer initiation;Cancer Model;Cells;cohort;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer risk;Computational Biology;CRISPR/Cas technology;Data;Development;Diet;diet-induced obesity;dietary;Dimensions;Discipline;early onset;early onset colorectal cancer;Ecosystem;Environment;Environmental Risk Factor;Epidemiologic Factors;Epidemiology;Epigenetic Process;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;Etiology;Exposure to;Fasting;fatty acid oxidation;feeding;fetal;Fetal Tissues;Fibroblasts;Generations;genome editing;Genomics;Goals;gut inflammation;gut microbiome;Health;High Fat Diet;high risk;Homeostasis;Human;Immune;Immunity;Immunology;imprint;in utero;in vivo;Incidence;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injury;innovation;Interleukin-6;intestinal epithelium;intestinal tumorigenesis;Intestines;Investigation;Ketone Bodies;Lesion;LGR5 gene;Life;Life Cycle Stages;life span;lifestyle intervention;Link;loss of function;Lymphatic;Lymphatic Endothelial Cells;Malignant Neoplasms;Mediating;Memory;MHC Class II Genes;microbiota;Mind;Modeling;mouse model;Mus;Natural regeneration;Nature;novel;Nutritional;Obesity;obesity in children;obesogenic;offspring;organoid transplantation;Organoids;pathogen;pharmacologic;Phase;Placenta;Polyamines;Population;Positioning Attribute;Predisposition;prenatal;Prevention;Process;progenitor;Protocols documentation;PubMed;Reporter;Reporting;Research;Resolution;Risk;Risk Assessment;Risk Factors;Role;Sampling;Science;Signal Transduction;Skin;small molecule;social determinants;Source;Specimen;stem;stem cell biology;stem cell function;stem cell homeostasis;stem cell model;stem cell niche;stem cells;stemness;Stromal Cells;stromal progenitor;Technology;tissue stem cells;Tissues;transcriptomics;Translating;tumor;Tumor Burden;tumor initiation;tumorigenesis;Tumorigenicity;Vision;Work

PROJECT_TITLE: PROSPECT - Stem cell models


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PI_NAMEs: MCCULLOUGH, LAUREN E (contact)

PROJECT_TERMS: Accounting;actigraphy;Address;Africa;African;African ancestry;Air;anti-cancer research;Area;biobank;Biological;Biological Markers;black patient;Black Populations;Cancer Biology;Cancer Center;cancer health disparity;cancer risk;cancer site;Cardiovascular Diseases;Characteristics;Climate;cloud based;cohort;Collaborations;Collection;Communicable Diseases;computer framework;Country;Data;Data Collection;Data Element;data repository;Databases;deprivation;design;Development;Diabetes Mellitus;Discrimination;early onset;Environment;Environmental Exposure;Epigenetic Process;Equipment;Equity;Etiology;formative assessment;Genetic;genome sequencing;Genomics;Geographic Locations;Geography;Germ Lines;Grant;Health;health care availability;Health Care Seeking Behavior;health seeking behavior;Heterogeneity;Immune response;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;indexing;Individual;insight;instrument;International;Intervention;Investigation;Leadership;Lived experience;Logistics;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Minority Groups;Monitor;Morbidity - disease rate;mortality;Natural Selections;Neighborhoods;Not Hispanic or Latino;novel;Outcome;outcome disparities;Pathogenicity;Patient advocacy;Patient Self-Report;Patients;Phenotype;Plasma;Political Factor;Politics;Population;precision oncology;Predisposition;pressure;Primary Neoplasm;profiles in patients;prospective;Protocols documentation;Questionnaires;Race;racism;recruit;Refractory;Reporting;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;Secure;Shapes;Site;Sleep;social;social determinants;social factors;social health determinants;social influence;social metrics;Standardization;structural determinants;structural health determinants;Surveys;sustainability framework;Target Populations;Technology;tool;Training;transcriptomics;treatment and outcome;trial design;tumor;Tumor Biology;Tumor Tissue;Underserved Population;Universities;Variant;virtual;whole genome;Work

PROJECT_TITLE: SAMBAI - Bridging Research Investigations of cancer Disparities and Global Equity (BRIDGE)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: NARRATIVE A quantitative understanding of viral dynamics and immunity in the lungs holds enormous promise for reducing the severity of respiratory viral infections. Computational models will be developed for predicting the multidimensional time and spatial characteristics of innate immune responses to influenza virus infection in the lung. Without such a mathematical framework, the design of therapies will be slowed, or worse, dangerous, and faulty.

PI_NAMEs: WICHMAN, HOLLY A (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Adaptive Immune System;Address;Animal Experimentation;Augmented Reality;Biology;Biomedical Research;Cell Culture Techniques;Cells;Characteristics;Communities;Complement;Complex;Computer Models;Dangerousness;Data;design;Development;digital twin;Dimensions;Disease;disorder control;Economics;Environment;Funding;Future;Genes;Goals;Host Defense;Idaho;Immune;Immune response;Immune system;Immunity;Immunology;Immunotherapeutic agent;improved;Infection;Inflammation;Influenza;influenza infection;Influenza Therapeutic;Innate Immune Response;Innate Immune System;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Interferon Type I;Interferons;Knowledge;Location;Lung;lung visualization;mathematical model;Mathematics;model development;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Outcome;Parameter Estimation;parent project;Pathogenesis;Pathogenicity;Pathology;programs;Pulmonary Pathology;Research;Research Activity;Research Project Grants;Resolution;respiratory;response;Role;Science;Scientist;Severities;Signal Transduction;Slice;spatiotemporal;Stains;Structure;Structure of parenchyma of lung;Technology;therapy design;Time;Tissue Sample;United States National Institutes of Health;Universities;Viral;Viral Antigens;Viral Respiratory Tract Infection;virology;virtual;virtual reality;virtual technology;Virus Diseases;Virus Replication;Visualization

PROJECT_TITLE: Center for Modeling Complex Interactons


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Hematology;Mental Health;Mental Illness;Neurosciences;Prevention;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE: Patients with hemophilia have significant bleeding events, but they also suffer from mental health disorders and demonstrate executive dysfunction more frequently than the general population. Our proposed studies aim to quantify volumetric brain differences, cerebral bleeds, and neuroinflammation to understand their impact on behavior outcomes. Understanding the neurophenotype in hemophilia may help in earlier screening, detection, and treatment of anxiety, depression, and neurocognitive deficits in hemophilia patients which would transform current patient care standards.

PI_NAMEs: STABER, JANICE MARIEROSE (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3 year old;Address;Adult;Affect;Age;Amygdaloid structure;Anatomy;Animal Model;Anxiety;anxiety treatment;arthropathies;Behavior;behavior measurement;behavior test;Behavioral;behavioral outcome;behavioral phenotyping;Brain;brain abnormalities;Brain Diseases;Brain Injuries;Brain region;brain volume;Caring;Cerebellum;cerebral microbleeds;Cerebrum;Child;Chronic Disease;Cognitive;cohort;comorbidity;conditioned fear;Darkness;Data;design;Detection;Development;disability;Early Diagnosis;early screening;Event;Executive Dysfunction;Exhibits;experimental study;Factor VIII;Frequencies;Functional disorder;Gene Transfer Techniques;General Population;glial activation;Goals;Health;Hemophilia A;Hemorrhage;Hippocampus;Histologic;human disease;Hypothalamic structure;imaging study;improved;Incidence;Infant;Injections;innovation;insight;Intracranial Hemorrhages;joint injury;Joints;Lead;Light;Link;Measures;Mental Depression;Mental disorders;Meta-Analysis;Modeling;Mononuclear;mouse model;Mus;Myopathy;neonatal period;Nervous System Disorder;Nervous System Physiology;Neuroanatomy;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neuroimaging;neuroinflammation;Neurologic;Neurological outcome;Neuropathogenesis;neuropsychiatric disorder;neuropsychiatry;Non-Viral Vector;novel therapeutics;Outcome;Pathway interactions;Patient Care;Patients;Persons;Phenotype;prevent;Prevention;Prevention strategy;Preventive;Process;prophylactic;Prophylactic treatment;Publishing;Quality of life;Reporting;Research;Review Literature;Risk;Role;Schedule;sex;Signs and Symptoms;standard of care;Stress;Structure;Testing;Time;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: Understanding of a neurophenotype in hemophilia A


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PHR: Delaware Center for Neuroscience Research Public Health Relevance Summary The foundation of Phase III proposal is Delaware’s expanding set of human and research resources in neuroscience, which has Delaware neuroscience research competitive on a national level. Our project supports research aimed at determining how thoughts, memories, feelings and actions emerge from dynamic activities in the brain and are changed over time; as well educational programs to develop a workforce that can participate in and benefit from advances in our understanding of brain function. An increased understanding of how the brain and nervous system functions will facilitate treatments for diseases and injuries and provide insights into human behavior, biases, and cognition.

PI_NAMEs: HARRINGTON, MELISSA A (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Animals;Applications Grants;Award;base;Basic Science;Behavior;biomedical imaging;Biomedical Research;Brain;Brain imaging;Caliber;career;Cells;Centers of Research Excellence;Cognition;Collaborations;Communities;Core Facility;Data;Delaware;Development;Disease;Education;Electrodes;Electrophysiology (science);Ensure;Environment;equity, diversity, and inclusion;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Faculty;Faculty Recruitment;Feeling;Fostering;Foundations;Funding;Genetic;Goals;Grant;Historically Black Colleges and Universities;Human;Human Resources;human subject;improved;Infrastructure;Injury;innovation;insight;Institution;inter-institutional;Invertebrates;Investments;life span;Magnetic Resonance Imaging;meetings;member;Memory;Mentored Research Scientist Development Award;Mentors;Minority;Modeling;Molecular;Nervous System;Nervous System Physiology;neuroimaging;Neurosciences;Neurosciences Research;non-invasive imaging;operation;patch clamp;Phase;Physiology;Pilot Projects;Productivity;Program Development;programs;public health relevance;Publications;Research;Research Activity;research data dissemination;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Rodent Model;Services;skills;Slice;Structure;Structure-Activity Relationship;Study Section;success;symposium;Thinking;Time;Tissues;Training;Training Activity;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Vocational Guidance

PROJECT_TITLE: COBRE Phase III: Delaware Center for Neuroscience Research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PI_NAMEs: STEGMAIER, KIMBERLY  (contact)

PROJECT_TERMS: age group;aspirate;Biochemistry;Biological;Biology;biomarker development;Brain;CAR T cell therapy;Chemicals;Chemistry;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Chromatin;Clinical;clinical application;clinical implementation;Clinical Trials;Collaborations;CRISPR/Cas technology;Cyclins;Dana-Farber Cancer Institute;Dependence;Development;Disease;drug development;Drug Targeting;drug testing;early phase clinical trial;engineered T cells;Ependymoma;Epigenetic Process;Equilibrium;Evaluation;Event;Ewings sarcoma;functional genomics;Future;Gastrointestinal Stromal Tumors;Genetic;Glioma;Glues;high risk;improved;inhibitor;innovation;insight;Intervention;Lead;lead optimization;Leadership;lenalidomide;Ligands;Malignant Childhood Neoplasm;Maps;member;Menin;Methods;Modality;Modeling;Molecular;mortality;multicatalytic endopeptidase complex;Neuroblastoma;next generation;novel;novel strategies;Nuclear RNA;Oncogenic;Oncoproteins;patient engagement;Patient Representative;Patients;Pediatric Neoplasm;Pediatric Oncology;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;pre-clinical;preclinical evaluation;preclinical study;Preclinical Testing;Property;protein degradation;Protein Inhibition;protein protein interaction;Proteins;Protocols documentation;prototype;RELA gene;Research;Research Personnel;Resistance;resistance mechanism;response;Risk;Risk Taking;RNA Transport;screening;small molecule;Solid Neoplasm;Source;structural biology;success;Survival Rate;synovial sarcoma;System;Technology;Thalidomide;Therapeutic;therapeutic target;Tumor Biology;Ubiquitin;ubiquitin ligase;Validation;Work

PROJECT_TITLE: PROTECT (Harnessing PROTEin degradation for Advanced Childhood Tumors)


NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Nutrition;Obesity

ORG_DEPT: CHEMISTRY

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Animal studies have demonstrated that the regulation of food intake requires articulation among endogenous cannabinoids (ECs), fatty acid-binding proteins (FABPs), and a peroxisome proliferator- activated nuclear receptor (PPARa), but the macromolecular basis for appetite, satiety, and obesity is poorly understood. This project will probe the solution-state macromolecular structure and function of EC- FABP, EC-PPAR, and FABP-EC-PPAR complexes in vitro at near-physiological concentrations, determining affinities, metabolic fates, molecular binding interfaces, and conformational changes to test proposed mechanisms of EC metabolic signaling. Working as a team with research trainees, our work will help to understand health risks and design future therapies for heart disease, autoimmune disorders, and type-2 diabetes.

PI_NAMEs: STARK, RUTH E. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Abbreviations;Address;Affinity;Amides;Animal Model;Animals;Appetite Regulation;Applications Grants;Articulation;Autoimmune Diseases;Binding;Binding Proteins;Binding Sites;Biological Assay;Biophysics;career;Cell Nucleus;Chemicals;Chimera organism;Complex;design;Desire for food;Diffusion;Dissociation;Drug Design;Drug Modulation;endocannabinoid signaling;Endocannabinoids;Enterocytes;Enzymes;Esters;Exhibits;experimental study;fatty acid amide hydrolase;fatty acid-binding proteins;Fatty Acids;Fluorescence;Food Intake Regulation;Future;Genetic Transcription;Glycerol;Health;heart disease risk;Heart Diseases;Human;Hydrophobicity;In Vitro;in vitro testing;Inflammation;Intestines;Knock-out;Knockout Mice;Ligand Binding;Ligand Binding Domain;Ligands;Lipase;Liver;Measures;Mediating;member;Metabolic;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;Molecular Structure;Monitor;Mus;neuroprotection;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear Receptors;Obesity;Outcome;Pain;Pattern;Peroxisome Proliferator-Activated Receptors;Peroxisome Proliferators;Phenotype;Physiological;preference;pressure;programs;Protein Binding Domain;protein complex;protein protein interaction;Proteins;receptor binding;recruit;Regulation;Relaxation;Research;Risk;Role;Satiation;Signal Transduction;Signaling Molecule;Site;Surface Plasmon Resonance;Testing;Thermodynamics;Thinness;thyroid hormone receptor associated protein 220;Titrations;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Research Supplement to Promote Diversity in Health-Related Research: Undergraduate Students


ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The proposed research aims to elucidate the role of the protein MOSMO in the Hedgehog signaling pathway, which is critical for embryonic development and tissue regeneration. The study focuses on how MOSMO interacts with other components of the MOSMO/MEGF8/MGRN1 complex to regulate the cell surface abundance of the Hedgehog effector Smoothened (SMO). Through systematic mutagenesis and functional assays, the research will investigate MOSMO's potential roles as a chaperone, activator, and localization factor to understand its influence on Hedgehog signaling.

PI_NAMEs: KONG, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Applications Grants;Biochemistry;Biological Assay;career development;Cell Culture Techniques;Cell surface;Cells;Cholesterol;Cilia;Complex;Cues;Data;embryo tissue;Embryonic Development;Erinaceidae;extracellular;Funding;graduate school;graduate school preparation;Integral Membrane Protein;Learning;meetings;Molecular;Molecular Chaperones;morphogens;Mutagenesis;parent grant;Postbaccalaureate;posters;predictive modeling;Process;Proteins;Protocols documentation;Research;Research Personnel;Research Training;Role;SHH gene;Signal Transduction;smoothened signaling pathway;success;Talents;Technical Expertise;tissue regeneration;Transducers;ubiquitin-protein ligase;undergraduate student;Universities;Washington;Work

PROJECT_TITLE: Molecular mechanisms that regulate target cell sensitivity to Hedgehog morphogens


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: SYRACUSE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SYRACUSE UNIVERSITY

PHR: Public Health Relevance Statement Despite its crucial role in the survival and growth of the fetus, our understanding of human placental development is quite limited due to the lack of practical experimental tools. The recent discovery of trophoblast differentiation potential of pluripotent stem cells offers great promise for filling this knowledge gap. In this R21 project, we will undertake an exploratory, high-risk but high-reward study to generate microfluidic placenta organoids using human induced pluripotent stem cells. This platform will facilitate the study of placental development and aid in the development of screening platforms for the diagnosis, prevention, and treatment of placenta dysfunction.

PI_NAMEs: MA, ZHEN ;ZHENG, YI  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abnormal placentation;Acceleration;Address;Adhesions;Animal Model;blastocyst;Carcinoma;Cell Differentiation process;Cell Line;Cell Lineage;cell motility;Cells;Characteristics;Chorionic villi;Circulation;Complex;Data Set;design;Development;Diagnosis;Dissociation;Early Diagnosis;Embryonic Development;Endometrial;endometrial stroma;Endometrium;Ensure;Epithelium;Ethics;Excision;experimental study;failure Implantation;Fetal Growth Retardation;Fetal Tissues;Fetus;First Pregnancy Trimester;Functional disorder;Goals;Growth;high reward;high risk;Hormone secretion;Human;human induced pluripotent stem cells;Image;In Vitro;in vivo;induced pluripotent stem cell;innovative technologies;Invaded;Investigation;Knowledge;Knowledge acquisition;life span;Location;Macaca;manufacture;Methodology;Microfluidic Microchips;Microfluidics;Modeling;Molecular;Morphogenesis;Morphology;natural Blastocyst Implantation;Neuregulin 1;nonhuman primate;Nutrient;Organoids;Oxygen;pathogen;pathogenic bacteria;Pathologic;Pharmaceutical Preparations;Phase;Physiological;Placenta;Placentation;Play;pluripotency;Pluripotent Stem Cells;Poison;Pre-Eclampsia;Pregnancy;Pregnancy Complications;prevent;Prevention;Process;Property;public health relevance;Publishing;Reproducibility;Reproduction;Research;Resolution;Role;Sampling;screening;Screening procedure;self organization;Signal Transduction;single-cell RNA sequencing;Source;Spontaneous abortion;stem cell derived tissues;stem cells;Syncytiotrophoblast;System;Time;Tissues;tool;transcriptome;transcriptomics;trophoblast;trophoblast stem cell;Uterus;Villous;Waste Products;wasting

PROJECT_TITLE: Stem Cell-Derived Microfluidic Placenta Organoids

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Digestive Diseases;Drug Abuse (NIDA only);Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Substance Misuse;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Hepatitis C virus infection has an increasing burden among pregnant and postpartum women, with the main risk group being women who use drugs. Recent clinical guideline changes recommended universal screening during each pregnancy, but we do not know if these guidelines have been widely implemented. We will apply rigorous econometric methods to national claims data to determine the extent to which the guideline update is related to increases in hepatitis C testing, treatment, and diagnosis of maternal to child transmission.

PI_NAMEs: KAPADIA, SHASHI  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Affect;Age;aged;American College of Obstetricians and Gynecologists;Birth;Caring;Cesarean section;Characteristics;Child;Cholestasis;Clinical;Complex;Data;design;Development;Diagnosis;Disease;Disparity;Drug usage;Drug user;econometrics;Enrollment;Equity;Ethnic Origin;Evaluation;experience;Failure;Guidelines;HCV screening;Health;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Heterogeneity;High Risk Woman;HIV;improved;Infant;Injecting drug user;injection drug use;Interruption;Intervention;intervention delivery;Laboratories;Link;Live Birth;Low Birth Weight Infant;maternal outcome;Measures;Mediating;Medicaid;Methods;Modification;Mothers;novel;opioid use disorder;Outcome;Patients;Perinatal;perinatal outcomes;perinatal period;Perinatal transmission;Pharmaceutical Preparations;Policies;Population;Positioning Attribute;Postpartum Period;Postpartum Women;Pregnancy;pregnancy hypertension;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal testing;Process;Professional Organizations;programs;Public Health;Public Policy;Race;Recommendation;Records;reproductive;Risk;Risk Factors;Sampling;screening;screening guidelines;Series;service delivery;Substance Use Disorder;Testing;testing uptake;Time;transmission process;Treatment outcome;trend;Update;uptake;Urbanicity;Variant;Vertical Transmission;virus testing;Woman

PROJECT_TITLE: Universal HCV screening in pregnancy: Examining testing uptake and HCV care

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (A1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PI_NAMEs: CARSON, TIFFANY LASHAUN (contact)

PROJECT_TERMS: Accounting;Address;Africa;African;African ancestry;anti-cancer research;Area;biobank;Biolectric Impedance;Biological;Biological Markers;black patient;Black Populations;Body Composition;Cancer Biology;Cancer Center;cancer health disparity;cancer risk;cancer site;Cardiovascular Diseases;Characteristics;Climate;cloud based;cohort;Collaborations;Collection;Communicable Diseases;computer framework;Country;Data;Data Collection;Data Element;data repository;Databases;deprivation;design;Diabetes Mellitus;Discrimination;early onset;Environment;Environmental Exposure;Epigenetic Process;Equipment;Equity;Etiology;formative assessment;Genetic;genome sequencing;Genomics;Geographic Locations;Geography;Germ Lines;Health;health care availability;Health Care Seeking Behavior;health seeking behavior;Heterogeneity;Immune response;Immunoassay;Immunologic Factors;Immunologics;improved;Incidence;indexing;Individual;Inequality;Inequity;insight;instrument;International;Intervention;Leadership;Lived experience;Logistics;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Minority Groups;Molecular;Monitor;Morbidity - disease rate;mortality;Muslim religion;Natural Selections;Neighborhoods;Not Hispanic or Latino;novel;Outcome;outcome disparities;Pathogenicity;Patient advocacy;Patient Self-Report;Patients;Phenotype;Plasma;Political Factor;Politics;Population;precision oncology;Predisposition;pressure;Primary Neoplasm;profiles in patients;prospective;Protocols documentation;Race;racism;recruit;Refractory;Reporting;Research;Research Personnel;Resources;response;Sampling;Science;Scientist;Secure;Shapes;Site;social;social determinants;social factors;social health determinants;social influence;Standardization;Stress;structural determinants;structural health determinants;Surveys;sustainability framework;Target Populations;Technology;tool;Training;transcriptomics;treatment and outcome;trial design;tumor;Tumor Biology;Tumor Tissue;Underserved Population;Universities;Variant;virtual;Vulnerable Populations;whole genome;Work

PROJECT_TITLE: SAMBAI - Establishing a comprehensive assessment of contributors to cancer inequities across the African diaspora


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

PHR: PROJECT NARRATIVE UPLIFT and PACES are two evidence-based epilepsy self-management programs whose adoption and impact is limited by the lack of sustainable funding models. We propose an economic evaluation of these programs that will utilize data from completed, ongoing and new MEW Network trials in both healthcare and community settings, as well as surveys of trained program implementers across the country. By generating data on implementation costs and cost-effectiveness of UPLIFT and PACES, we will provide critical evidence to inform strategies to enhance their adoption and sustainability, ultimately leading to improved health and quality of life among diverse PWE.

PI_NAMEs: FRIEDMAN, DANIEL ;GOLD, HEATHER TAFFET;ISLAM, NADIA S;SPRUILL, TANYA M (contact)

PROGRAM_OFFICER_NAME: DARLING, NATALIE

PROJECT_TITLE: Economic Evaluation of MEW Network Epilepsy Self-Management Programs

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (08)]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This application is being submitted for continued funding for Generation Tomorrow: Summer Health Disparity Scholars (GT:SHDS) as a part of the FY24 CFAR Diversity, Equity, and Inclusion Pathway Initiative (CDEIPI). GT:SHDS was launched under the leadership of Drs. Risha Irvin, Nathan Irvin, and Denis Antoine in 2019 and was designed to support and attract undergraduate students nationwide that are interested in HIV and/or hepatitis C virus (HCV) health disparities and their intersection with substance use, violence, mental health, and the social determinants of health. Through CDEIPI, the program has been expanded to include a graduate student training track.

PI_NAMEs: ANTOINE, DENIS GODWIN;CHAISSON, RICHARD E. (contact);IRVIN, NATHAN ALEX;IRVIN, RISHA

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;AIDS prevention;Area;Award;Baltimore;base;Belief;Bioinformatics;Biological Assay;career;Career Mobility;Clinical;Clinical Pharmacology;Clinical Research;Collaborations;combat;Communication;Communities;community based research;community building;community intervention;community organizations;Community Outreach;community partners;community partnership;Comprehensive Health Care;Consultations;Counseling;cultural competence;data sharing;design;Development;disadvantaged background;Discipline;Discipline of Nursing;Disparity population;Education;Electronic Mail;Epidemic;epidemic preparedness;equity, diversity, and inclusion;ethnic disparity;experience;Exposure to;Extramural Activities;Faculty;First Generation College Students;Foundations;Funding;Future;Generations;Goals;Government Agencies;graduate student;Grant;Harm Reduction;Health;health disparity;Health Professional;Hepatitis C;Hepatitis C virus;Historically Black Colleges and Universities;HIV;HIV Infections;HIV/AIDS;HIV/HCV;Immunology;Individual;Information Dissemination;innovation;instrument;interest;Interest Group;Investments;Laboratories;Leadership;Link;Lived experience;Medical;Medicine;meetings;Mental Health;Mentors;Mentorship;Methods;Mid-Atlantic Region;Minority Groups;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Newsletter;next generation;Overdose;Participant;Pathway interactions;Patients;Population;Positioning Attribute;Preparation;Prevention;Productivity;programs;Public Health;racial disparity;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk;Role;Science;Services;Sister;social health determinants;social interventions;Specimen;State Interests;Statistical Methods;student training;substance use;summer program;symposium;Testing;tool;Training;Treatment outcome;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;Update;Violence;virology;Vision;web site;working group

PROJECT_TITLE: The CFAR Diversity, Equity, and Inclusion Pathway Initiative to Support The Continued Development of Generation Tomorrow (JHU CFAR Supplement)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Mental Health;Social Determinants of Health

PI_NAMEs: IRVIN, RISHA  (contact)

PROJECT_TERMS: addiction;African American;Agriculture;Baltimore;Belief;Black race;career;Clinical;Collaborations;college;Communities;Community Health;community organizations;Community Outreach;community partners;Comprehensive Health Care;Continuity of Patient Care;Counseling;Country;County;cultural competence;Data;Development;disadvantaged background;disadvantaged student;Discipline of Nursing;Disparity population;economic disparity;Education;Education and Outreach;equity, diversity, and inclusion;Ethnic Origin;experience;Exposure to;First Generation College Students;Florida;Funding;Generations;graduate student;Harm Reduction;Health;Health Disparities Research;health disparity;Health Professional;Health Services;Hepatitis C;Hepatitis C virus;Historically Black Colleges and Universities;HIV;HIV/HCV;improved;improved outcome;Indigenous;Individual;Intervention;Latinx;Learning;lectures;Lived experience;Louisiana;Maryland;Mechanics;Medicine;Mental Health;Mentors;Mentorship;Minority Groups;Minority-Serving Institution;multidisciplinary;Nursing Students;outreach;Overdose;Participant;Pathway interactions;Patients;peer coaching;people of color;programs;Public Health;Race;racial population;Research;Science;Scientist;Series;Sister;social health determinants;State Interests;student training;Students;substance use;summer program;Testing;Training;undergraduate student;Underrepresented Students;United States;Universities;Violence;virus testing


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PI_NAMEs: DAVIS, MELISSA B (contact)

PROJECT_TERMS: Accountability;Address;Advocate;Africa;African;African ancestry;anti-cancer research;Area;biobank;Biochemistry;Biological;black patient;Cancer Center;cancer health disparity;catalyst;Clinical;Clinical Oncology;Clinical Research;cloud based;cohort;Collaborations;Communication;community engagement;computer framework;Data;Data Element;data integration;data management;data platform;data portal;data repository;Databases;deprivation;Development;Doctor of Philosophy;early onset;Ensure;Environment;Environmental Exposure;Epigenetic Process;Equity;Ethics;Ethics Committees;Evaluation;experience;Genetic;genome sequencing;Genomic medicine;Genomics;Geography;Germ Lines;Goals;Immunoassay;Immunologic Factors;Immunologics;Immunology;improved;Incidence;indexing;Inequality;Inequity;Infrastructure;Ingestion;Institute of Medicine (U.S.);Institution;International;Investigation;Leadership;Link;Lived experience;Logistics;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mass Spectrum Analysis;Measurement;Measures;member;Methods;Microbiology;Modeling;Molecular;Molecular Biology;Morehouse School of Medicine;novel;Office of Administrative Management;operation;outcome disparities;Participant;Patient advocacy;Patient Self-Report;Patients;Performance;Plasma;Population;precision oncology;Predisposition;Primary Neoplasm;profiles in patients;prognostic assays;programs;Progress Reports;Proteomics;Psychosocial Stress;racism;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;Risk;Rivers;Science;Scientist;Site;social;social determinants;Structure;success;Surveys;sustainability framework;Target Populations;Technology;technology development;Theoretical model;tool;transcriptomics;translational genomics;treatment and outcome;trial design;tumor;Tumor Tissue;Underserved Population;virtual;whole genome;Work

PROJECT_TITLE: CANCER GRAND CHALLENGES 2024 SOCIETAL, ANCESTRY, MOLECULAR AND BIOLOGICAL ANALYSES OF INEQUALITIES (SAMBAI) Morehouse School of Medicine


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Exposure to cues associated with opioid use can trigger relapse in recovering opioid users, even after long periods of abstinence. The proposed experiments focus on oxycodone, a widely prescribed opioid analgesic that is a significant contributor to the opioid crisis. Our rat studies will be the first to assess the role of synaptic plasticity in the nucleus accumbens, a critical brain region for motivation and reward, in the maintenance of oxycodone craving during protracted withdrawal from oxycodone self-administration.

PI_NAMEs: WOLF, MARINA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;abuse liability;Address;Adenosine;ADORA2A gene;AMPA Receptors;Amygdaloid structure;antagonist;Automobile Driving;Behavior;Brain region;cell type;Cells;Cocaine;cocaine self-administration;craving;Cue-induced relapse;Cues;Data;DRD2 gene;drug craving;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Epidemic;Ethanol;experimental study;Exposure to;Extinction;Female;Future;Genetic;Genetic study;Glutamates;Goals;Incubated;innovation;Interneurons;Learning;Link;Maintenance;male;Mediating;Methamphetamine;Modeling;Morphine;motivated behavior;Motivation;negative affect;Negative Reinforcements;Neuroglia;Neurons;Nicotine;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid use;opioid use disorder;opioid user;opioid withdrawal;Oxycodone;oxycodone seeking;oxycodone self-administration;Paper;patch clamp;Pathway interactions;Permeability;Pharmaceutical Preparations;Positive Reinforcements;prescription opioid;prescription opioid abuse;prevent;Process;Property;psychostimulant;Rat Transgene;Rattus;receptor;receptor expression;Relapse;response;Rewards;Rodent;Role;Saline;Self Administration;Specific qualifier value;Specificity;Stimulant;Structure of paraventricular nucleus of thalamus;Synapses;Synaptic plasticity;Synaptic Transmission;synthetic opioid;Testing;Time;transmission process;Up-Regulation;Withdrawal;Work

PROJECT_TITLE: Incubation of oxycodone craving and nucleus accumbens plasticity

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Stigma and depression are associated with increased HIV-related mortality and morbidity; as depression treatment is increasingly integrated into HIV care, addressing HIV stigma, mental illness stigma, and intersectional HIV-mental illness stigma is crucial. The proposed study will consolidate HIV and mental illness stigma reduction interventions within existing depression care for people living with HIV in Malawi and evaluate the HIV-mental illness stigma intervention’s implementation and impact on patient stigma, HIV and mental health outcomes using a hybrid design. The proposed research and training will provide me with the necessary skills to implement and evaluate high-impact multi-level stigma-reduction interventions that leverage existing mental health services, yield detailed insights into implementation barriers and facilitators, and ultimately support the wellbeing of people living with HIV in low-resource settings

PI_NAMEs: STOCKTON, MELISSA ANN (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;anti-depressive agents;career;Caring;Clinical;community advisory board;community based participatory research;comorbid depression;coping mechanism;Country;Data;Depressed mood;depressed patient;design;Educational workshop;effectiveness/implementation hybrid;effectiveness/implementation study;effectiveness/implementation trial;empowerment;Epidemic;Epidemiology;evidence base;Evidence based intervention;experience;Focus Groups;Foundations;Goals;Government;Health;Health Sciences;Health Services Accessibility;HIV;Hybrids;implementation barriers;implementation evaluation;implementation facilitators;implementation intervention;implementation outcomes;implementation process;implementation research;implementation science;improved;Individual;innovation;insight;intersectionality;Intervention;Interview;Investments;Knowledge;Level of Evidence;Malawi;Measures;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;Nature;Outcome;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Phase;pilot trial;Policies;programs;Provider;psychoeducation;Psychotherapy;Reporting;Research;Research Personnel;Resource-limited setting;scale up;Site;skills;social stigma;Stereotyping;Stigmatization;Strategic Planning;symposium;Testing;Training;treatment program;treatment services;Work

PROJECT_TITLE: Improving HIV and Depression Outcomes by Reducing HIV-Mental Illness Stigma in Malawi: a pilot effectiveness-implementation trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-T(04)]


PHR: Project Narrative The NYUGSOM-CUNY Prevention Research Center is responding the two-part call for Collaborating and Coordinating Centers in SIP-24-012 Advancing Research in Immunization Services Network. The enclosed proposal aims to (1) provide novel insight on how parents of young children who once held vaccine hesitant or skeptical attitudes come to vaccinate their children in accordance with CDC guidelines, (2) outline a step-by- step, managerial process for federally-qualified health centers to adopt an evidence-based, “opt-out” approach to childhood vaccinations and offers ethical considerations for prospective adopters and (3) builds a coordinating center that can not only facilitate and synthesize between CDC-funded projects but also network with an array of additional related partners.

PI_NAMEs: ISLAM, NADIA S;RATZAN, SCOTT C.;TAYLOR, LAUREN ANNE (contact)

PROJECT_TITLE: ARISe Coordinating and Collaborating Centers for the Study of Vaccine Hesitancy and Uptake (CDC SIP 12)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (09)]


PHR: NARRATIVE Despite the growing number of evidence-based cancer prevention and control interventions and strategies to reduce the burden of cancer, most are not well adopted in local clinical or community settings. The Emory CPCRN will increase the translation of cancer and lung cancer screening (LCS) evidence into local communities and heath systems. We will conduct a scoping study of lung cancer screening tools, a systematic review of LCS interventions in the U.S., and a stepped wedge, clustered RCT to assess differences in lung cancer risk assessment, referral, and screening between the intervention and control groups to reduce lung cancer morbidity and mortality.

PI_NAMEs: ESCOFFERY, NGOC-CAM  (contact);KEGLER, MICHELLE C

PROJECT_TITLE: SIP-24-003 Cancer Prevention and Control Research Network (CPCRN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 FMC (04)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative: The proposed study will rigorously measure and assess the consequences of state abortion restrictions on pregnancy loss management practices and outcomes, to understand the impact of abortion restrictions on other pregnancy care and to evaluate the effect on existing racial and socio-economic care disparities. This study will also provide new tools for improved surveillance of pregnancy loss and management practices. Findings from this study will fill knowledge gaps and provide critical insights that may guide future organizational and state policy.

PI_NAMEs: FLINK-BOCHACKI, RACHEL ;NEWTON-LEVINSON, ANNA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: 3-Dimensional;abortion;Affect;Attention;Attitude;black patient;Black race;Caring;Case Study;Characteristics;Clinical;Clinical Management;clinical practice;Computerized Medical Record;Confusion;Data;Data Aggregation;Data Collection;Data Set;Databases;Decision Making;design;Disparity;Distress;Emotional;Environment;Evaluation Research;evidence base;experience;First Pregnancy Trimester;Fright;Future;Goals;Health;health care disparity;health organization;Health Policy;Health Services;Health system;Healthcare;improved;Indigenous;Individual;Induced Abortion;Influentials;insight;Institution;Interview;Knowledge;Laws;Low income;maternal morbidity;Maternal Mortality;Measurement;Measures;Medical;Medical Records;Methods;Monitor;multidisciplinary;Outcome;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;Pattern;people of color;Persons;Policies;Policy Making;Politics;Practice Management;practice setting;Pregnancy loss;Prenatal care;preservation;Protocols documentation;Public Health;Qualitative Methods;Quality of Care;Quasi-experiment;Race;racial disparity;Records;recruit;Reproductive Health;Second Pregnancy Trimester;socioeconomics;Spontaneous abortion;stillbirth;success;Supportive care;Supreme Court Decisions;System;Testing;Time;tool;trend;United States;Variant;Women's Health

PROJECT_TITLE: An exploratory sequential mixed methods study on pregnancy loss care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-Z (57)]


PHR: PROJECT NARRATIVE This proposal aims is to expand the capacity of the AFRICURE program to recruit, mentor, and support early- and mid-career African investigators to address Africa-specific biologic, therapeutic, and implementation issues in HIV cure research. The AFRICURE program will be integrated into the JHU CFAR Development Core and coordinated through the Inter-CFAR Sub-Saharan Africa Working Group. The AFRICURE program addresses the critical need for inclusivity and diversity in HIV cure research by fostering a new generation of African HIV cure investigators.

PI_NAMEs: CHAISSON, RICHARD E. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Africa;Africa South of the Sahara;African;African Women;AIDS clinical trial group;antiretroviral therapy;Area;Award;Biologic Characteristic;Biological;career;career development;Clinical Trials Network;Collaborations;collaboratory;combat;Communities;community building;Country;Cultural Characteristics;design;Development;diversity and inclusion;Environment;Epidemic;Epidemiology;experience;Fostering;Funding;Generations;Geographic Locations;Goals;Grant;Health;HIV;HIV-1;HIV/AIDS;Income;Individual;Infrastructure;innovation;insight;Institution;institutional capacity;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Knowledge;Leadership;low and middle-income countries;male;Measures;Medicine;meetings;men;Mentors;Mentorship;Mind;multidisciplinary;neglect;next generation;novel;Outcome;parent grant;Pathway interactions;Persons;Population;Population Heterogeneity;Process;Productivity;programs;Publications;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Scientific Advances and Accomplishments;Scientist;Services;Shoulder;skill acquisition;Testing;Therapeutic;Underrepresented Populations;United States;Universities;viral rebound;Viral reservoir;working group

PROJECT_TITLE: The Johns Hopkins Center for AIDS Research (JHU CFAR) AFRICURE


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: SALEEM, HANEEFA TASLEEM (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Africa;Africa South of the Sahara;African;African Women;AIDS clinical trial group;Ally;antiretroviral therapy;Area;Award;Biologic Characteristic;Biological;career;career development;Clinical Trials Network;Collaborations;collaboratory;community building;Country;Cultural Characteristics;design;Development;diversity and inclusion;Environment;Epidemic;Epidemiology;experience;Fostering;Generations;Geographic Locations;Goals;Grant;HIV;HIV-1;Income;Individual;Infrastructure;innovation;insight;Institution;institutional capacity;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interruption;Knowledge;Leadership;low and middle-income countries;male;Measures;meetings;men;Mentors;Mentorship;Mind;neglect;novel;Outcome;Pathway interactions;Persons;Population;Population Heterogeneity;Process;programs;Publications;recruit;Research;research and development;Research Personnel;Research Project Grants;Resources;Role;Scientific Advances and Accomplishments;Scientist;Shoulder;skill acquisition;Testing;Therapeutic;United States;Universities;viral rebound;Viral reservoir;working group

PROJECT_TITLE: The Johns Hopkins Center for AIDS Research (JHU CFAR) - AFRICURE


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative The proposed team-science project between the University of Mississippi Medical Center and Mississippi State University in collaboration with Mississippi Center for Clinical and Translational Research and Mississippi Center of Excellence in Telehealth, seeks to validate virtual reality-based tools to enhance neurological assessment and treatment techniques. This will be accomplished through three co-projects, using novel wearable technology and lab-based assessments, providing comprehensive cognitive, biomechanical, neuromuscular, and subjective measures. This team-science project is in direct alignment with many new and ongoing strategic initiatives in Mississippi around the concept of innovation and wearable and/or medical device technologies for potential use with telehealth.

PI_NAMEs: GRANGER, JOEY P. (contact)

PROGRAM_OFFICER_NAME: BISSONETTE, GREG

PROJECT_TERMS: Address;Adherence;Adult;Ankle;Biomechanics;Brain;Brain region;Caring;cerebral autoregulation;Cerebrum;Clinic;Clinical;clinical center;clinical practice;Clinical Research;Cognitive;cognitive testing;Collaborations;cost;Custom;Data;Data Analyses;Data Collection;Diagnosis;Effectiveness;effectiveness evaluation;efficacy evaluation;efficacy testing;Environment;Equilibrium;experience;Exposure to;Fall prevention;fall risk;Financial Hardship;foot;Functional impairment;functional status;Future;Goals;hazard;Health;health disparity;Health Personnel;Health Services Accessibility;Healthcare Systems;Hemodynamic Processes;hemodynamics;Human;Impairment;improved;Individual;innovation;innovative technologies;intervention program;kinematics;Kinetics;Lower Extremity;Measures;Medical;Medical center;Medical Device;medical specialties;member;mild traumatic brain injury;Mississippi;Modeling;Monitor;Motion;Movement;Muscle;Musculoskeletal Equilibrium;Near-Infrared Spectroscopy;Nervous System Physiology;Neuroanatomy;Neurocognitive;neurocognitive test;Neurologic;neuromuscular;novel;novel strategies;oculomotor;older adult;Participant;Patient Care;Patients;Pattern;Performance;Persons;Population;Posture;pressure sensor;Process;Questionnaires;Reality Testing;Rehabilitation therapy;remote assessment;remote therapy;Research;research clinical testing;response;Rural;rural area;satisfaction;Science;Scientist;sensor;simulation;Smooth Pursuit;standard of care;Stimulus;Stretching;Symptoms;System;Techniques;Technology;technology validation;telehealth;teleneurology;Testing;Time;tool;Training;Training Programs;Translating;Translational Research;trauma centers;treadmill;Universities;virtual;virtual environment;virtual reality;virtual reality environment;virtual reality headset;Visual;wearable device


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Infectious Diseases;Prevention

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE: Overall As demonstrated by the COVID-19 pandemic, infectious diseases are continuously evolving threats that cause substantial morbidity and mortality in all populations. Toward the prevention and control of globally important infectious diseases, we propose continuation of the Translational Global Infectious Diseases Research (TGIR) Center. The TGIR Center supports the research and career development of the next generation of scientists in biomedical and quantitative/computational scientific fields and builds a strong collaborative research team to diminish the global health burden from infectious diseases.

PI_NAMEs: KIRKPATRICK, BETH DIANE (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: academic program;Advisory Committees;Applications Grants;Area;Award;biobank;career;career development;Centers of Research Excellence;Clinical;Collaborations;Communicable Diseases;Complement;Computer Models;Core Facility;COVID-19 pandemic;data management;Data Scientist;Dedications;design;Development;Discipline;Education;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;global health;Goals;Grant;Growth;Human;improved;Individual;Infectious Diseases Research;Institution;interest;Language;Leadership;Logistics;Mathematics;meetings;member;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel;Phase;Physicians;Pilot Projects;Population;Population Research;Positioning Attribute;predictive modeling;prevent;Prevention;Process;Program Development;programs;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Resource-limited setting;Role;Scholars Program;Science;Scientist;senior faculty;Services;Structure;success;Training and Education;training opportunity;Training Programs;Translational Research;Universities;Update;Vermont;visiting scholar

PROJECT_TITLE: Translational Research to Prevent and Control Global Infectious Diseases(Translational Global Infectious Diseases Research Center, TGIR)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: This project identified a potent and clinically-relevant target, Transient Receptor Potential – Canonical 6 (TRPC6), that is hyperactivated in Duchenne muscular dystrophy (DMD) and contributes to heart disease. The proposed research will test 1) the only known TRPC6-inhibiting drug in three mouse models of DMD and 2) newly-developed engineered heart tissue platform that can simultaneously assess mechanical stress responses in human engineered heart tissue from Duchenne muscular dystrophy stem cell lines

PI_NAMEs: LIN, BRIAN LEEI (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Acute;Address;Adult;Arrhythmia;Attenuated;biological adaptation to stress;Biological Assay;Biological Availability;Biomedical Engineering;Blinded;Blood Vessels;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;career;Cations;Cell Death;cell injury;Cell Line;Cell Separation;cell type;Cells;Chronic;Clinical;Clinical Trials;clinically relevant;Complementary therapies;coronary fibrosis;Custom;Data;Defect;Deformity;Disease;Duchenne muscular dystrophy;dystrophic cardiomyopathy;Dystrophin;efficacy testing;Fibroblasts;Fibrosis;Functional disorder;Future;Gene Deletion;gene therapy;Genetic;Goals;Heart Diseases;Heart failure;heart function;Histologic;Histopathology;Human;Human Engineering;human induced pluripotent stem cells;Hyperactivity;Immobilization;improved;in vivo;induced pluripotent stem cell;Inflammatory;inhibitor;Ion Channel;Kidney Diseases;Length;life span;Lung Diseases;mdx mouse;Measures;mechanical load;mechanical stimulus;Mechanical Stress;Mechanics;Mediating;Membrane;Methods;micro-dystrophin;Modeling;Molecular;mortality;mouse model;Mus;Muscle;Muscle Cells;Muscle function;Muscle Weakness;Muscular Dystrophies;muscular dystrophy mouse model;Myocardial dysfunction;Myocardium;Myopathy;novel;novel therapeutics;nuclear factors of activated T-cells;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;post-doctoral training;prevent;Profibrotic signal;randomized placebo controlled trial;receptor;Receptor, Angiotensin, Type 1;Reporting;Research;Residual state;response;Role;Sampling;Sarcolemma;sealant;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeletal Muscle;skills;small molecule inhibitor;Spinal;stem cells;Stress;Stress Tests;Stretching;Striated Muscles;System;Testing;Time;Tissue Model;Training;Treatment Efficacy;Utrophin

PROJECT_TITLE: TRPC6 inhibition therapy to rescue cardiac muscle dysfunction in muscular dystrophy

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Project Narrative For medical emergencies, every second matters, and despite attempts to train and standardize rural clinicians to employ best practices for high acuity, low occurrence (HALO) events, such as cardiac arrest, it is well-described that patients have worse outcomes in rural community hospitals than in urban hospitals. Using two different simulation technology modalities for neonatal resuscitation, a HALO event, our project will compare adherence to Newborn Resuscitation Program (NRP®) guidelines, teamwork, and communication and evaluate the psychometric properties of the modified NRP® adherence assessment tool when used in our rural telesimulation training program. This study will refine the HoloBabyTM, a mixed-reality simulation prototype, and provide validity data to an NRP® adherence assessment tool, which can be used for evaluation of performance to provide feedback in simulated and real resuscitation scenarios, improving care delivery in rural areas.

PI_NAMEs: SAWYER, DOUGLAS B (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: acute care;Address;Adherence;Algorithms;Applications Grants;Area;Assessment tool;care delivery;care systems;Caring;Centers of Research Excellence;Cessation of life;Childhood;Clinical;Clinical Research;Collaborations;Communication;Community Hospitals;Computer software;cost;Country;County;critical access hospital;Cross-Over Studies;Data;Delivery Rooms;design;Development;Devices;Economics;education research;Educational Models;Emergency Medicine;Emergency Situation;Environment;Evaluation;Event;experience;extended reality;Feedback;Goals;Guidelines;health care disparity;health inequalities;Health Personnel;Heart Arrest;hologram;Hospitals;improved;improved outcome;Infant;Infant Care;Infant Mortality;innovation;Intervention;Knowledge;life span;Maine;Manikins;Measures;Medical;Medical emergency;Methodology;mixed reality;Modality;Morbidity - disease rate;mortality;Neonatal;neonatal care;Neonatal Mortality;neonatal resuscitation;neonate;Neonatology;Newborn Infant;novel;Outcome;outcome disparities;parent grant;Patients;Performance;Pharmaceutical Preparations;Population;preservation;programs;Property;prototype;Psychometrics;Readiness;Reduce health disparities;Research;Research Personnel;Resources;response;Resuscitation;Rural;rural area;Rural Community;rural counties;rural disparities;Rural Hospitals;rural patients;rural setting;rurality;Safety;Scientific Advances and Accomplishments;Scientist;simulation;Site;skills;Standardization;standardized care;Teaching Hospitals;Technical Expertise;Technology;Time;tool;Training;training opportunity;Training Programs;Travel;United States;United States National Institutes of Health;Universities;Urban Hospitals;urban setting;Validity and Reliability;Video Recording

PROJECT_TITLE: Center of Biomedical Research Excellence in Acute Care Research and Rural Disparities


ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative This project brings together the complementary expertise of two laboratories to tackle the challenges of developing a wide variety of organo- and metal-catalyzed amination reactions to prepare structurally diverse chiral amines. Olefins will be directly converted to enantiomerically enriched NH- and N-alkylaziridines via catalytically-generated N-electrophilic oxaziridines, ketimines and ketiminoesters will furnish fully-substituted amines upon catalytic asymmetric allylation, while arenes will be converted to the corresponding chiral and sterically hindered N-alkylanilines via catalytic C-H amination and using novel electrophilic aminating agents with previously inaccessible structural complexity. The resulting unprotected amine products are highly prized by the synthetic/medicinal chemistry communities and the new environmentally friendly chemical transformations (i.e., green chemistry) that emerge will expedite synthetic access to and reduce the production cost of highly functionalized nitrogen-containing materials and ultimately will lead to the faster development of new medicines.

PI_NAMEs: KURTI, LASZLO  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New catalytic methods for the rapid synthesis of N-unprotected chiral aziridines and amines

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PI_NAMEs: SGOURAKIS, NIKOLAOS  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Address;algorithm development;algorithm training;Algorithms;Antigen Presentation;Antigen Targeting;Antigens;aqueous;Binding;Biochemical;Biological Assay;cancer therapy;cancer type;combinatorial;Complex;Computer Models;Computing Methodologies;cross reactivity;cytotoxicity;Data;Data Analyses;Data Set;design;Development;Engineering;Environment;Event;Exhibits;experimental study;extend lifespan;Face;Feedback;Generations;Goals;Grant;high throughput screening;Human;Immobilization;immune checkpoint blockade;Immune response;Immune system;Immunity;immunogenicity;Immunology;Immunotherapy;improved;In Vitro;insight;Institution;Laboratories;large scale data;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Melanoma;method development;Methods;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular recognition;mouse model;next generation;NMR Spectroscopy;novel drug class;Nuclear Magnetic Resonance;Peptide/MHC Complex;Peptides;personalized medicine;Pharmaceutical Preparations;Physiological;Play;prediction algorithm;Proteins;Proxy;quantum;Receptor Activation;Research Personnel;Resolution;response;Role;Sampling;Source;Specificity;structural biology;Structure;success;Surface;Surface Plasmon Resonance;System;T cell response;T cell therapy;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;TCR Activation;Testing;Therapeutic;therapy design;tool;Toxic effect;Training;training data;tumor;Tumor Antigens;Uncertainty;Viral;Vision;Work

PROJECT_TITLE: MATCHMAKERS - Solving TCR recognition and design via integrated high-throughput screening, structural, functional, and computational approaches