NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Radiation Oncology

PI_NAMEs: FEARON, ERIC R. (contact)

PROJECT_TERMS: Advertisements;anti-cancer research;Award;Basic Science;Biometry;Budgets;Cancer Center;career;Clinical;Collaborations;Communities;Data Reporting;data submission;Development;Early treatment;Elements;Ensure;Evaluation;Exclusion;expectation;Faculty;Feedback;Fostering;Funding;Future;Goals;Grant;high risk;Human;innovation;Institution;Laboratories;Locally Advanced Malignant Neoplasm;member;Mentors;Mentorship;Michigan;Molecular Target;Monitor;novel;operation;Outcome;peer;Population Research;pre-clinical;Process;Program Research Project Grants;programs;Protocols documentation;Radiation therapy;Radiosensitization;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Schedule;Seasons;translational impact;translational potential;Treatment-Related Cancer;United States National Institutes of Health;Universities;web site;Writing

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Schizophrenia

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project narrative: The proposed research aims to determine the health outcomes of different deprescribing strategies of antipsychotics used for behavioral and psychological symptoms of dementia in a skilled nursing facility. Our study will generate direct evidence that facilitates timely deprescribing of potentially inappropriate medications in people living with dementia. It will also yield a novel analytical framework specializing in comparative safety and effectiveness analyses of discontinuing psychotropic treatments with detailed subgroup analyses informative for individualized deprescribing decisions.

PI_NAMEs: LIN, JOSHUA K (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Address;Adopted;Adverse event;adverse outcome;Affect;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;Antipsychotic Agents;Arrhythmia;Behavior;Behavior Therapy;Behavioral;Behavioral Symptoms;Black Box;care delivery;Certification;Cessation of life;Characteristics;Chronic;Clinical;clinical phenotype;comorbidity;comparative;comparative effectiveness analysis;comparative safety;Complex;Confusion;Data;data mining;Data Set;Delirium;Dementia;Detection;Dimensions;Dose;Dose Rate;electronic health database;electronic health information;Electronic Health Record;evidence base;Exclusion;frailty;Goals;Guidelines;Health;health assessment;Heterogeneity;high dimensionality;Hospitalization;Hypotension;Impaired cognition;Individual;innovation;kidney dysfunction;Knowledge;Liver Dysfunction;Machine Learning;Measures;Medicare claim;medication safety;Methods;mortality;novel;older adult;Outcome;Pain management;participant retention;Patient Selection;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Phenotype;phenotyping algorithm;Pneumonia;Polypharmacy;Predictive Value;Procedures;Process;Provider;Proxy;psychological symptom;psychotic;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;routine care;Schedule;Scheme;Schizophrenia;Serious Adverse Event;Severities;Severity of illness;Signal Transduction;Skilled Nursing Facilities;Solid;Subgroup;Surveys;Symptoms;Time;tool;treatment effect;trial comparing;United States Food and Drug Administration;Ventilatory Depression;Weight

PROJECT_TITLE: Deprescribing antipsychotics in patients with Alzheimers disease and related dementias and behavioral disturbance in skilled nursing facilities

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative: In severe traumatic brain injury intracranial pressure (ICP) is monitored to treat raises in ICP with the goal of maintaining adequate cerebral blood flow (CBF) and critical closing pressure (CrCP) and prevent secondary brain injury. ICP alone cannot separate benign ICP elevations from flow-limiting pressure spikes. By combining superconducting nanowire single photon detectors (SNSPD) with diffuse correlation spectroscopy (DCS) operating at 1064 nm, we propose to develop a bedside CBF, CrCP and ICP monitor that offers a leap forward in performances when compared to existing DCS technology and demonstrate feasibility and utility in the ICU environment. If successful, this device will enable better guided management of a larger number of brain injury patients resulting in improved neurological outcomes.

PI_NAMEs: FRANCESCHINI, MARIA ANGELA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acoustics;Adult;Affect;Algorithms;Benign;Bilateral;Blood flow;Blood Pressure;Brain;Brain Injuries;brain parenchyma;brain surgery;Cardiac;Caring;Cerebral perfusion pressure;Cerebrovascular Circulation;Cerebrum;Clinical;clinical care;Clinical Investigator;clinical translation;commercialization;Computer software;cost;cranium;Critical Illness;Data;design;Detection;detector;Devices;Diameter;Diffuse;Environment;Erythrocytes;Fiber;General Hospitals;Goals;heterodyning;high risk;Hospitals;improved;improved outcome;indexing;Infection;instrument;Intervention;Intracranial Hemorrhages;Intracranial Hypertension;Intracranial Pressure;Lasers;Light;light weight;Lighting;Linear Regressions;machine learning algorithm;manufacturability;Massachusetts;Measures;Microcirculation;Mind;Monitor;Morphology;Motion;nanowire;Nerve Sheaths;Neurological outcome;Noise;non-invasive monitor;operation;Optic Nerve;Optics;Oxygen saturation measurement;Parameter Estimation;Patient-Focused Outcomes;Patients;Performance;Perfusion;personalized medicine;photon-counting detector;Physiologic pulse;Physiology;Pilot Projects;portability;pressure;prevent;prototype;quantum;response;Risk;Role;Scalp structure;sensor;Signal Transduction;software development;Source;Spectrum Analysis;standard of care;System;Technology;technology development;Time;tool;Training;Transcranial Doppler Ultrasonography;Traumatic Brain Injury;Tympanic membrane;Visualization;Woman;Work

PROJECT_TITLE: SNSPD-DCS at 1064 nm for non-invasive monitoring of cerebral perfusion and intracranial pressure in the ICU

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-D(81)S]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: LJUNGMAN, MATS  (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Articulation;Basic Science;Cancer Biology;Cancer Patient;career;career development;clinical practice;Clinical Trials;Clinical Trials Design;Conduct Clinical Trials;Correlative Study;Development;Early identification;Educational Curriculum;Ensure;Ethnic Population;Evidence based practice;expectation;experience;Faculty;Fostering;Funding Mechanisms;Goals;Grant;health equity;Health Sciences;Individual;interest;Laboratories;Leadership;leadership development;Life;Locally Advanced Malignant Neoplasm;Manuscripts;Measures;Mediation;member;Mentors;Mentorship;Michigan;Minority Groups;Minority-Serving Institution;Molecular Target;Monitor;novel;novel strategies;Participant;Patient Care;peer;Peer Review;preclinical study;Preclinical Testing;programs;Qualifying;racial population;Radiation;Radiobiology;Radiosensitization;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Scientist;senior faculty;skills;success;support network;Testing;Training;Training Support;Translating;translational potential;Translational Research;translational scientist;Translations;Universities;Woman;Work;Writing

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because defects in mitochondria are at the heart of many diseases including heart disease, neurodegeneration, and cancer. Therefore, the proposed research plan to elucidate the fundamental principles underlying mitochondrial network morphology and dynamics is relevant to the part of NIH's mission that seeks to mitigate the burden of human disease by developing fundamental knowledge of the processes driving disease. In addition, the proposed work seeks to develop methodologies that make mitochondria research more accessible to other researchers, thereby accelerating the advent of new therapies.

PI_NAMEs: SCHOENEBERG, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: 3-Dimensional;Acceleration;Adoption;Algorithms;Alzheimer's Disease;Automobile Driving;Biogenesis;Biology;Biophysics;Cardiomyopathies;Cell Volumes;Cells;Cellular biology;Cellular Metabolic Process;Communities;Computer software;computerized tools;Data;Data Analyses;data modeling;Data Set;deep learning;deep neural network;Defect;Development;Diffusion;Disease;Equilibrium;Event;Evolution;experimental analysis;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Four-dimensional;Goals;Grant;Graph;Heart;Heart Diseases;Homeostasis;human disease;Image;Image Analysis;image processing;Imaging technology;Impairment;Kidney Bean;Knowledge;Lead;Light;Link;Location;Malignant Neoplasms;Measures;Methodology;Methods;microscopic imaging;Microscopy;Mission;Mitochondria;Modeling;models and simulation;Modernization;Morphology;Motility;Nerve Degeneration;neural network architecture;Neurosciences;novel therapeutics;Organelles;particle;Polymers;Process;Public Health;Reading;Research;Research Personnel;Resolution;Role;segmentation algorithm;Seizures;Shapes;simulation;software development;spatiotemporal;Stress;Stroke;terabyte;Testing;Textbooks;Time;tool;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: Modeling and Analysis of the Spatio-Temporal Dynamics of the Mitochondrial Network

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurosciences;Nutrition;Pain Research;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH The financial and societal burden of gut disorders and visceral pain is a major problem in the US, especially for women. Irritable bowel syndrome is a highly prevalent functional disorder without clear pathology that degrades the quality of life. Our team seeks to understand the mechanistic underpinnings of the gut-brain axis in order to shed light on this prevalent intestinal disorder.

PI_NAMEs: INGRAHAM, HOLLY A. (contact);JULIUS, DAVID

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acute;Affect;afferent nerve;Afferent Neurons;alternative treatment;Anabolism;Anatomy;antagonist;Basic Science;biophysical analysis;biophysical properties;Brain Diseases;Cells;Chemicals;Chronic;Chronic pain syndrome;cohort;Colitis;Colon;Communication;Data;Data Set;design;designer receptors exclusively activated by designer drugs;Diet;Disease;Disproportionately impacts women;Endogenous Factors;Enterochromaffin Cells;Environmental Risk Factor;Enzymes;ESR1 gene;Esthesia;Estrogens;Exhibits;Female;Functional disorder;Genetic;Genetic Models;Genetic Transcription;gut microbes;gut microbiota;gut-brain axis;High Fat Diet;high reward;high risk;hormonal signals;Hormones;Human Characteristics;Hypersensitivity;Inflammatory;Ingestion;innovation;interest;Intestinal Diseases;intestinal epithelium;Intestines;intravital imaging;Irritable Bowel Syndrome;Irritants;Lipids;Maintenance;Mediating;Mediator;microbiome;Modeling;Molecular;Mucous Membrane;Mus;mutant;Nature;Nerve Fibers;Nervous System;neurophysiology;novel;Organoids;Ovariectomy;Pain;Pain Threshold;Pathology;Patients;Persistent pain;Pharmacology;Pharmacology Study;Phase;Physiological;Physiology;Population;potential biomarker;pre-clinical;Property;Proteomics;Public Health;Quality of life;receptor;Rectum;Reporting;response;Role;Science;Sensory;Serotonin;Sex Differences;sex disparity;Signal Transduction;Sorting;Stimulus;Testing;Time;tissue injury;Tissues;transcriptome sequencing;Visceral;Visceral pain;Woman;women versus men;Work

PROJECT_TITLE: Understanding Mechanisms and Sex-Differences in Visceral Pain

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Lung;Nutrition;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Tobacco;Tobacco Smoke and Health

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: The Hillock is a newly discovered cellular structure within the mammalian airway. While it is injury resistant and is able to regenerate the airway post-injury, it also has some similarities to squamous metaplasia, which is thought to be a precancerous lesion. This work will define the relationship of the hillock with squamous metaplasia as well as provide critical information on the molecular pathways that regulate hillocks’ differentiation and expansion.

PI_NAMEs: CHERNOFF, CHAIM ZEV (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Ablation;Adult;airway epithelium;airway regeneration;Alleles;Alveolus;Asthma;Atmosphere;Basal Cell;Biological Assay;Biology;cell type;Cells;Cellular Structures;Cervix Uteri;Chemicals;Chronic Obstructive Pulmonary Disease;cigarette smoke;Cystic Fibrosis;Cytokeratin;Data;Differentiation and Growth;Disease;Distal;Dominant-Negative Mutation;Environment;epithelial repair;epithelial stem cell;Epithelium;epithelium regeneration;Gases;Genetic;Gland;Homeostasis;Human;inhibitor;injured airway;Injury;injury and repair;Lesion;Lung;Maintenance;Malignant Squamous Cell Neoplasm;Mediating;Modeling;Molecular;Mus;Myoepithelial;Naphthalene;Natural regeneration;Nature;novel;Oxygen;Pathologic;Pathway interactions;Population;premalignant;Process;Proliferating;Pseudostratified Epithelium;re-epithelialization;Reagent;Renal pelvis;Reporting;Reproducibility;Reserve Stem Cell;Resistance;response;Retinoic Acid Receptor;Role;Signal Transduction;single-cell RNA sequencing;small molecule;Smoking;Source;Squamous Cell Lung Carcinoma;Squamous Epithelium;Squamous Metaplasia;stem cells;Structure;Sulfur Dioxide;Surface;Testing;Tissues;Tobacco smoke;Trachea;Tracheal Epithelium;Tretinoin;Vitamin A;Vitamin A Deficiency;Work

PROJECT_TITLE: The Hillock: A Newly Discovered Airway Epithelial Structure and its Relationship with Squamous Metaplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

ORG_STATE: MD

PHR: In response to severe respiratory infections like influenza and SARS-CoV-2, a mediator of inflammation called HMGB1 is released from dying cells and leads to the “cytokine storm” associated with disease progression. Our novel inducible platform produces an inhibitor of HMGB1 in response to inflammation that is expected to counteract disease and be broadly applicable against many different inflammatory agents.

PI_NAMEs: BLANCO, JORGE C (contact);VOGEL, STEFANIE N.

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adenovirus Vector;Adenoviruses;Agonist;Animal Model;antagonist;Bacterial Infections;Biological Markers;cell injury;Cells;Cessation of life;chemokine;clinically relevant;Cotton Rats;COVID-19 cytokine storm;COVID-19 pandemic;cytokine;cytokine release syndrome;Data;Dengue Virus;Development;Dimerization;Disease;Disease Progression;Ebola virus;efficacy testing;Engineering;Experimental Animal Model;Family;Gene Expression;Goals;HMGB1 gene;Homeostasis;Hospitalization;Human;human disease;human pathogen;Immune response;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;Inflammatory Response;Influenza;influenza infection;influenza virus strain;inhibitor;Injury;Innate Immune Response;innovation;insight;Intervention;Life;Ligands;Lipopolysaccharides;Lung;Mediating;Mediator;microorganism interaction;Molecular;mouse model;Multiple Organ Failure;Mus;novel;novel strategies;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Phase;pre-clinical;Predisposition;Process;Production;prototype;Publishing;Pulmonary Inflammation;receptor;Reporting;Research;Resolution;Respiratory Disease;Respiratory Tract Infections;respiratory virus;response;Rodent Model;SARS-CoV-2 exposure;SARS-CoV-2 infection;Sepsis;Severity of illness;Sigmodon;Signal Pathway;Signal Transduction;Small Business Technology Transfer Research;small molecule;Sterility;Structure;Symptoms;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;TLR4 gene;Toll-like receptors;tool;translational therapeutics;Treatment Efficacy;Viral;Virus;Work

PROJECT_TITLE: Inducible HMGB1 antagonist for viral-induced acute lung injury.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Clinical Research;Diabetes;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors can result in long-lasting clinical responses in a variety of advanced or metastatic malignancies, but approximately half of patients receiving these drugs develop autoimmune endocrinopathies. Our proposal brings together expertise in three complementary areas such as endocrinology, autoimmunity, and oncology. The outcome of this investigation will provide mechanistic insights into immunotherapy-related adverse events and may provide the groundwork for understanding how to limit the toxicity of immunotherapy as well as improving treatments of autoimmune endocrine diseases.

PI_NAMEs: LEE, HYUN-SUNG  (contact);REDONDO, MARIA JOSE

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Addison's disease;Adrenal Cortex;Adverse event;Affect;Antibodies;Area;Autoantibodies;Autoimmune;Autoimmune biomarker;Autoimmune Diabetes;Autoimmune Diseases;autoimmune thyroid disease;Autoimmunity;autoreactive T cell;B-Lymphocytes;Biological Markers;Blocking Antibodies;Body System;cancer immunotherapy;Case Study;CD8B1 gene;Cells;checkpoint receptors;checkpoint therapy;Circulation;Clinical;Clinical Trials;Clonal Expansion;college;common treatment;Complex;Coupled;COVID-19 pandemic;CTLA4 gene;Cytometry;Data;Development;Diabetes Mellitus;Diabetic Ketoacidosis;Disease;Disease remission;Early identification;Early treatment;Endocrine;Endocrine System Diseases;Endocrinology;Enzymes;Epitopes;Extracellular Domain;follow-up;Gene Expression;health care delivery;high dimensionality;Histocompatibility Antigens Class II;Human;Image;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immune-related adverse events;Immunity;Immunologic Factors;Immunologics;immunoregulation;Immunotherapy;immunotoxicity;improved;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;Investigation;Life;Ligands;Malignant Neoplasms;Malignant Pleural Mesothelioma;Mediating;Medicine;Memory;Molecular;Monoclonal Antibodies;Neoadjuvant Therapy;Neurosecretory Systems;novel;novel marker;Oncology;Outcome;Pancreatitis;Pathway interactions;Patients;Pattern;performance tests;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Population;prevent;Production;programmed cell death ligand 1;programmed cell death protein 1;randomized trial;remote health care;Reporting;Research;Resectable;response;risk stratification;Severity of illness;single-cell RNA sequencing;Solid Neoplasm;Steroid 21-Monooxygenase;success;Syndrome;T-Lymphocyte;tertiary lymphoid organ;Testing;Therapeutic Intervention;Thyroid Diseases;Time;Toxic effect;TP53 gene;tumor;tumor-immune system interactions;Variant;virtual;Visit;working group

PROJECT_TITLE: NOVEL HUMORAL AND CELLULAR BIOMARKERS OF AUTOIMMUNE DISEASES CAUSED BY IMMUNOTHERAPY

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE A low nicotine product standard could improve public health by reducing the prevalence of smoking. The current proposal aims to examine the real-world impact of a low nicotine product standard for smoked tobacco in New Zealand to inform the US nicotine reduction policy agenda recently announced by the Biden Administration. We propose to follow a cohort of New Zealanders who smoke daily or near daily, with an emphasis on enrolling priority smoking populations, before and after policy implementation to understand the impact of a low nicotine product standard on tobacco use behavior, health, and well-being.

PI_NAMEs: DENLINGER-APTE, RACHEL  (contact);DONNY, ERIC CHRISTIAN

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Address;Administrative Supplement;Adult;Age;Alcohol consumption;Area;authority;Behavior;behavioral outcome;behavioral pharmacology;Biochemical;Biological Markers;Biometry;Body mass index;Cardiovascular Physiology;Cigarette;cohort;Cohort Studies;Complex;Data;Dependence;economic disparity;Enrollment;Ensure;Epidemiology;Ethnic Population;Evaluation;Exposure to;Feeling;Gender;Goals;Government;Health;health assessment;health disparity;health equity;health inequalities;health related quality of life;Heavy Drinking;Heterogeneity;Home;improved;Indigenous;Individual;Individual Differences;International;Interview;Lead;low nicotine content cigarette;marijuana use;Medical Records;Medicine;Mental Depression;Mental Health;Methods;New Zealand;Nicotine;nicotine use;Outcome;Patient Self-Report;Perception;Personal Satisfaction;Persons;physical conditioning;Physiological;Policies;Population;primary outcome;Psyche structure;Public Health;pulmonary function;randomized, clinical trials;recruit;Regulation;Reporting;Research;Research Personnel;response;Sampling;self-reported anxiety;Smoke;Smoking;Smoking Behavior;smoking prevalence;social;socioeconomics;Subgroup;Surveys;Time;Tobacco;tobacco products;Tobacco smoke;Tobacco use;United States;Weight;young adult;Youth

PROJECT_TITLE: Assessing the real-world impact of a low nicotine product standard for smoked tobacco in New Zealand


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Over 60% of adolescents diagnosed with depression do not receive mental health care and treatment engagement is low among those who do access care. This mixed-methods study will build a fully functional Asynchronous Remote Communities (ARC) platform to supplement behavioral activation (BA+ARC) therapy for depressed adolescents and test its feasibility, usability, and effect on adolescent outcomes. BA+ARC is an innovative, scalable tool that utilizes a private online platform to provide peer and therapist coaching, chatbot supported therapy tools, and real-time mood and behavior tracking to improve access, engagement, and usability of adolescent depression treatments.

PI_NAMEs: JENNESS, JESSICA LYNNE (contact);KIENTZ, JULIE

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Address;Adolescent;adolescent health;adolescent mental health;adolescent patient;arm;Behavior;behavior change;Behavioral;behavioral outcome;Behavioral Sciences;Caring;chatbot;child depression;Chronic;Clinic;Clinical Treatment;Clinical Trials;Communities;COVID-19 pandemic;Data;Data Collection;Data Security;data visualization;depressive symptoms;design;Development;Diagnosis;digital;digital delivery;digital tool;disability;Ecological momentary assessment;Effectiveness;effectiveness trial;Elements;Engineering;Ethnic Origin;Evaluation;evidence base;feasibility testing;Feedback;Functional impairment;Funding;Future;Goals;Health Insurance Portability and Accountability Act;Health Services Accessibility;human centered design;Improve Access;improved;improved outcome;information gathering;innovation;Intervention;light weight;Mediating;Mental Depression;Mental Health;Mental Health Services;Methods;mobile computing;Modeling;Monitor;Moods;Motivation;National Institute of Mental Health;novel;Outcome;Outpatients;Participant;Patient-Focused Outcomes;Patients;peer;Pilot Projects;pilot test;Population;preventive intervention;Privatization;prototype;Psyche structure;Psychiatry;psychosocial;Race;Randomized, Controlled Trials;remote communities;Reporting;Research;Research Personnel;Resource-limited setting;Service delivery model;service intervention;Site;skills;social;Social Interaction;social media;Socioeconomic Status;Strategic Planning;Symptoms;synchronous therapy;Technology;technology platform;Teenagers;Testing;Time;tool;Universities;usability;Washington;Work

PROJECT_TITLE: Evaluation of an Asynchronous Remote Communities Approach to Behavioral Activation for Depressed Adolescents


ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: By integrating new technological and conceptual approaches; this proposed project will help discovering how cortical oxygenation, metabolic rate, and blood flow responses at the microvascular scales change during healthy aging and how they vary across different regions and depths of awake mouse brain. Moreover, this work will support better interpretation of the signal from oxygen-sensitive clinical neuroimaging methods, by quantifying these responses under common calibration procedures, including breathing challenges such as increased oxygen and/or carbon dioxide concentration, and intake of pharmaceuticals such as caffeine.

PI_NAMEs: SENCAN-EGILMEZ, IKBAL  (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: Affect;Age;Aging;Anesthesia procedures;Animal Model;Area;arterial spin labeling;arteriole;awake;biomedical imaging;biophysical model;Biophysics;Blood capillaries;Blood flow;blood oxygen level dependent;Blood Vessels;Brain;BRAIN initiative;Brain Mapping;Brain Pathology;Breathing;Caffeine;Calibration;Carbon Dioxide;career development;Catheters;Cerebrovascular Circulation;Cerebrum;Chronic;Clinical;Complex;Computer Models;Cortical vasculature;Coupled;Data;Development;Diameter;Environment;experimental study;Faculty;Functional Magnetic Resonance Imaging;Gases;General Hospitals;Goals;Health;healthy aging;hemodynamics;Human;Hypercapnia;Hyperoxia;Image;Imaging Device;imaging modality;improved;Injections;insight;Intake;interdisciplinary collaboration;Intraventricular;Ipsilateral;Link;Maps;Massachusetts;Measurement;medical schools;Mentors;metabolic rate;Metabolism;Methodology;Methods;microscopic imaging;middle age;Modeling;Morphology;Mus;Nature;neuroimaging;Neurons;Neurosciences;neurovascular coupling;new technology;next generation;Noise;novel;Optics;Oxygen;Partial Pressure;Pathologic;Pharmacologic Substance;Positioning Attribute;pressure;Procedures;Radiology Specialty;Research;Research Design;Research Methodology;Resolution;response;Rest;Shoulder;Signal Transduction;Technology;tenure track;Time;Tissues;tool;Training;training opportunity;two-photon;venule;Vibrissae;Visual;Work

PROJECT_TITLE: Effects of standard fMRI calibrations on the diverse microvascular blood flow and oxygenation responses in cortical layers

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Radiation Oncology;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Aberrant activation of the transcription factor NRF2, a key regulator of the cellular oxidative stress response, is frequently seen in HPV negative head and neck squamous cell carcinoma and is associated with a poor prognosis. Functionally validated somatic mutations of this pathway can only account for 30% of the observed activation. The objective of this proposal is to identify and characterize novel genomic and proteomic mechanisms of NRF2 activation in order to advance strategies for the diagnosis and targeted treatment of patients with NRF2 active tumors.

PI_NAMEs: SCHRANK, TRAVIS P. (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Address;autocrine;Binding;Biochemical;Biochemistry;Bioinformatics;biological adaptation to stress;Biology;Biophysics;cancer cell;cancer genomics;cancer type;career;CDKN2A gene;Cells;Classification;Clinical;Complex;CUL3 gene;Data;Development;Diagnosis;DNA Sequence Alteration;Doctor of Philosophy;Faculty;Gene Expression;Gene Expression Profiling;Genes;genetic signature;Genetic Transcription;genetic variant;Genomics;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV-negative head and neck cancer;improved;Institution;K-Series Research Career Programs;Knowledge;Label;Machine Learning;machine learning classification;MDM2 gene;Mediating;member;Mentorship;Methods;Molecular Biology;Mutation;Neurotensin;Neurotensin Receptors;North Carolina;novel;novel strategies;oral HPV-positive head and neck cancers;Otolaryngology;overexpression;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Prognosis;programs;prohormone;Proteins;Proteomics;Radiation;radiation resistance;radiation response;Radiation Tolerance;Radiosensitization;Reading Frames;Reporting;Repression;Research;Research Personnel;Resources;RNA;Role;Scientist;Signal Transduction;Site;Somatic Mutation;Surgeon;targeted treatment;Time;tool;TP53 gene;Training;training data;Transactivation;transcription factor;Transcriptional Activation;translational genomics;Treatment Failure;treatment risk;tumor;Universities;unsupervised clustering;Variant;Vocational Guidance;Work

PROJECT_TITLE: Mechanisms Determining Dysregulation of the NRF2 Oxidative Stress Response in Head and Neck Squamous Cell Carcinoma

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Hematology

PHR: PROJECT NARRATIVE This proposal seeks to elucidate the regulation of protein kinase C (PKC) theta () by phosphorylation and how this impacts function and biology. I have selected several critical phosphorylation residues (T538, S662, S676, S685, and S695) for further analysis with the goal of determining how each of these regulate PKC function and signaling. These fundamental studies will offer novel insights into the regulation of PKC in T cells and platelets, with application in immune and blood disorders.

PI_NAMEs: HODAPP, STEFANIE JILL (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Affect;Agonist;Autoimmune Diseases;Automobile Driving;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Response Modifiers;Biology;Biosensor;Blood Platelets;CD28 gene;Cells;Cellular Assay;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Diglycerides;Disease;Enzymes;Exhibits;experience;Experimental Designs;experimental study;Genes;Goals;Hematological Disease;Hematopoietic;Hematopoietic Neoplasms;Hemostatic function;Hydrolysis;Hydrophobicity;Immune signaling;Immune System Diseases;In Vitro;Inflammatory;insight;Investigation;Isoenzymes;Jurkat Cells;Knowledge;Laboratories;Location;Luciferases;Mass Spectrum Analysis;mimetics;Molecular;Mutation;novel;nuclear factors of activated T-cells;paralogous gene;pathogen;Pathology;Pathway interactions;pharmacologic;Phospholipids;phosphoproteomics;Phosphorylation;Phosphotransferases;Platelet Activation;Play;Positioning Attribute;Property;Protein Kinase C;protein kinase C-delta;receptor;Regulation;Reporter;Research;response;Role;selective expression;Signal Pathway;Signal Transduction;Site;T-Cell Receptor;T-Lymphocyte;Tail;Techniques;Thrombosis;tool;Training;transcription factor;Transcription Factor AP-1;Transcriptional Activation;Vision;Work

PROJECT_TITLE: Regulation of Protein Kinase C Theta by Phosphorylation


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Scientists have developed the ability to coax cells from human donors to grow into miniature pieces of neural tissue known as “brain organoids”. These organoids express genes and recapitulate aspects of neurodevelopment that are shared with their human donors, allowing insight into individual-specific disease processes and potential treatments. This project seeks to understand how human donors feel and think about brain organoids grown from their cells, with the ultimate goal to ensure that future brain organoid research is conducted in accordance with donor values.

PI_NAMEs: MACDUFFIE, KATE E. (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Alzheimer's Disease;Animal Model;Animals;Attitude;autism spectrum disorder;Award;Back;Basic Science;Behavior;Belief;Belief System;biobank;Bioethics;Biological;Brain;brain based;Brain Diseases;BRAIN initiative;career;Cell Line;Cell model;Cells;Child;Childhood;Clinical;clinical application;Clinical Data;Code;Communication;Consent Forms;Data;Data Collection;Development;Disease;DNA;Education;efficacy testing;Environment;Ethical Issues;Ethics;experience;Faculty;Family;Family member;Functional disorder;Future;Genes;Goals;Human;human model;human subject;Imaging Techniques;improved;In Vitro;in vitro Model;Individual;induced pluripotent stem cell;Informed Consent;innovation;insight;Interview;Joubert syndrome;Kidney;Knowledge;Laboratories;Learning;Link;Lung;Master of Science;Measures;Mentors;Modeling;Modification;Morals;multidisciplinary;Nerve Degeneration;Nervous System Disorder;neural;neural network;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;neuroethics;Neurosciences;Neurosciences Research;neurotechnology;non-invasive imaging;Organ;Organoids;Participant;Pathology;patient engagement;Patients;Pattern;Phase;pilot test;Play;Policies;Positioning Attribute;preference;Process;Protocols documentation;Registries;Research;Role;Sampling;Scientist;self organization;skills;sociodemographic factors;sociodemographics;Specimen;stakeholder perspectives;stem cells;Structure;surrogate decision maker;Surveys;Technology;three-dimensional modeling;Time;Tissues;Training;Universities;Washington;working group

PROJECT_TITLE: The experience of human subjects with brain organoid research


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Hematology;Immunotherapy;Mental Health;Physical Activity;Prevention;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: OMAHA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE The number of older adults who are 60 years and older undergoing hematopoietic cell transplantation as part of cancer treatment has more than doubled in the past decade. Older adults undergoing these transplants are at high risk of experiencing a decline in cognitive function afterwards that can affect day-to-day function and quality of life. Our project seeks to develop and test an exercise-based intervention to preserve cognitive function and improve quality of life among transplant recipients.

PI_NAMEs: KOLL, THUY  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;active control;Address;Adoption;Adult;Affect;Age;Age Years;aging related disease;Attention;Behavioral Sciences;Brain;Cancer Survivor;Cancer Survivorship;cancer therapy;cardiorespiratory fitness;Caring;chemotherapy;Chronic;Clinical;clinical practice;clinical trial implementation;Cognition;Cognition Disorders;Cognitive aging;cognitive benefits;cognitive change;cognitive function;Collaborations;collaborative approach;Communities;Community Health;Data;design;disability;Distress;Effectiveness;effectiveness evaluation;effectiveness research;effectiveness/implementation design;effectiveness/implementation hybrid;Elderly;Evaluation;evidence base;executive function;Exercise;exercise intervention;Exercise Test;exercise training;experience;Feedback;functional improvement;functional outcomes;Future;future implementation;Geriatrics;Guidelines;Health;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Immune system;Immunosuppression;Impaired cognition;implementation context;implementation determinants;implementation intervention;implementation research;implementation science;implementation strategy;improved;Individual;Inflammation;Infusion procedures;innovation;Institution;Intervention;intervention delivery;Interview;K-Series Research Career Programs;Knowledge;Leadership;Life;Light;Malignant Neoplasms;Measures;member;Memory;Mentors;Mentorship;Methods;Modeling;Neuropsychological Tests;novel;older adult;older patient;Oncology;Outcome;Pathway interactions;Patients;Perception;Performance;Phase;Physical activity;Physical Function;Population;Positioning Attribute;preservation;prevent;primary outcome;Process;programs;Quality of life;Radiation therapy;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Personnel;Risk;Role;secondary outcome;sedentary activity;Severities;skills;stem cells;Structure;Survivors;Target Populations;Testing;Toxic effect;Training;translational study;Translations;Transplant Recipients;Transplantation;trial design;Vulnerable Populations;Work

PROJECT_TITLE: Promoting Physical Activity to Improve Cognitive Function in Older Adults Undergoing Hematopoietic Cell Transplantation (HCT)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Epigenetic information carriers and their signaling consequences play critical roles in all aspects of eukaryotic genome management, but many of their mechanisms remain poorly understood. My research program spans a host of traditional disciplines (discovery biochemistry, technology development, quantitative genomics, chemical biology, biophysics, and cell biology) with the goal of developing fundamental mechanistic understanding of epigenetic information systems.

PI_NAMEs: RUTHENBURG, ALEXANDER JACKSON (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Area;Binding;Biochemical;Biochemistry;Biology;Biophysics;Cell Nucleus;Cellular biology;Chemicals;Chromatin;Chromatin Structure;Cognition;Complex;Development;Discipline;Disease;DNA;DNA Modification Process;DNA Sequence;environmental change;Epigenetic Process;Family;Funding;Future;Genetic Transcription;Genome;Genomics;Goals;Hepatocyte;histone modification;Histones;Information Systems;Length;Modification;Molecular;National Institute of General Medical Sciences;Neurons;Nuclear;Nucleosomes;Physiological;Play;programs;Proteins;Research;RNA;Role;Signal Pathway;Signal Transduction;success;technology development;tool;tool development;Transcription Coactivator;transcription factor;Transcriptional Activation;Untranslated RNA;Variant;Work

PROJECT_TITLE: Defining the mechanisms of epigenetic information flow

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: DURHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Overall Component Narrative This grant supports facility infrastructure that enhances the capability of individual laboratories at Duke University to address basic molecular mechanisms, pathophysiology, biomarkers and outcomes of multiple blinding diseases, including but not limited to: age-related macular degeneration, glaucoma, retinitis pigmentosa, uveitis and dry eye. This grant also provides a collaborative environment critical for productive interactions among basic and clinician scientists and for raising the next generation of researchers studying biology and pathology of the visual system.

PI_NAMEs: ARSHAVSKY, VADIM Y (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Achievement;Address;Age related macular degeneration;Animal Model;Area;Basic Science;Biological Markers;Biology;Cell Physiology;Center Core Grants;Clinical;collaborative environment;Communities;community building;Core Grant;Development;direct application;Disease;educational atmosphere;Equipment;Experimental Ophthalmology;Eye diseases;eye dryness;Flow Cytometry;Fostering;Functional disorder;Glaucoma;Grant;Human;image processing;Individual;Infrastructure;innovation;interest;Laboratories;Mass Spectrum Analysis;member;Molecular;Molecular Biology;Morphology;neuronal circuitry;next generation;novel diagnostics;novel therapeutics;Ophthalmologist;Outcome;Pathology;Play;Productivity;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Retinitis Pigmentosa;Role;Scientist;Services;success;Sum;synergism;Techniques;Training;Translations;Universities;Update;Uveitis;Vision;Vision research;Visual System

PROJECT_TITLE: Center Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

PROJECT_TERMS: Accounting;Advisory Committees;Budgets;Center Core Grants;Communication;Communities;Contract Services;Core Facility;Core Grant;Development;Electronic Mail;Ensure;Equipment;Equity;Funding;Future;Goals;Grant;Human Resources;Infrastructure;Intranet;Investments;meetings;member;Methodology;Modification;Monitor;new technology;operation;Performance;Periodicals;Policies;repaired;Reporting;Research Personnel;Resource Allocation;Resources;Rotation;Scientist;Services;skills;Supervision;Universities;Update;Vision;Vision research;vision science;Visual;web site

PROJECT_TITLE: Admin Module


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: KAY, JEREMY N (contact)

PROJECT_TERMS: Artificial Intelligence;Automatic Data Processing;Center Core Grants;Communities;Computer software;computerized data processing;Custom;Data;Data Analyses;Dedications;Disease;Equipment;experience;Faculty;Fostering;Goals;Health;Histology;Human Resources;Image;Image Analysis;image processing;Imaging Device;imaging modality;imaging Segmentation;Individual;Laboratories;Manuals;Methodology;Microscope;Microtome - medical device;Morphology;next generation;Research;Research Personnel;Resource Sharing;Resources;Scientist;skills;Structure;Technical Expertise;Techniques;Time;Tissue Microarray;tissue preparation;tool;Training;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Morphology & Image Processing Module


ORG_CITY: Aurora

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this project is to understand the molecular mechanism mediating membrane traffic, signaling and actin-dependent dynamics during cell migration in vitro and in vivo. This project will lay the foundation for the establishing and defining a novel pathway of regulating cell migration and localized cytoskeleton remodeling. Completion of this project will then allow us to start investigating the mechanisms regulating cell migration during cancer cell metastasis, as well as during normal development.

PI_NAMEs: PREKERIS, RYTIS  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actins;AGFG1 gene;Binding;Binding Proteins;Biochemical;Biological Assay;C-terminal;cancer cell;cancer therapy;cell motility;Cellular biology;CISH gene;Complex;Cullin Proteins;Cytoskeleton;Data;Defect;design;Development;Extracellular Matrix;Family;Focal Adhesions;Foundations;Glutathione;Goals;Guanosine Triphosphate Phosphohydrolases;imaging approach;Immunoprecipitation;In Vitro;in vitro Assay;in vivo;in vivo evaluation;in vivo Model;Intracellular Membranes;Invaded;Knowledge;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Matrix Metalloproteinases;Mediating;member;Membrane;Membrane Protein Traffic;Microscopy;migration;Migration Assay;Modeling;Molecular;monomer;multidisciplinary;Mutagenesis;Neoplasm Metastasis;Neural Crest Cell;novel;Organ;Pathway interactions;Phosphoric Monoester Hydrolases;Process;Property;protein phosphatase 6;Proteins;Pseudopodia;Publishing;rab GTP-Binding Proteins;ras Oncogene;Regulation;Research;Role;scaffold;Shapes;Signal Transduction;Site;Testing;Three-Dimensional Imaging;Time;Tissues;trafficking;Transmembrane Transport;ubiquitin-protein ligase;Vertebrates;Work;Zebrafish;zebrafish development

PROJECT_TITLE: The mechanisms regulating actin dynamics and polarized membrane transport during cell migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Public Health Relevance Heavy drinking, sexual assault, and psychological distress are significant, co-occurring problems for young adult bisexual women. Psychological distress is a common aftereffect of trauma and intersects with minority stress and drinking to cope with psychological distress can increase risk for sexual revictimization. This study will involve developing and piloting an integrated intervention that designed to reduce alcohol use, sexual revictimization, and psychological distress among a particularly high-risk group – young adult bisexual women with a history of sexual victimization and who report heavy episodic drinking.

PI_NAMEs: ORCHOWSKI, LINDSAY MARIE (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Age;Age Years;alcohol behavior;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol misuse prevention;Alcohols;Anxiety;Assertiveness;Behavior;binge drinking;Bisexual;Clinical Trials;college;Communities;Competence;Control Groups;coping;Development;drinking;Education;empowerment;Enrollment;evidence base;Evidence based intervention;Face;Feedback;Focus Groups;follow-up;Forcible intercourse;Fostering;Frequencies;Goals;Harm Reduction;Health;Heavy Drinking;Heterosexuals;high risk population;homonegativity;Individual;informant;information gathering;innovation;Intervention;intervention delivery;Interview;intimate partner violence;Lesbian;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender Queer;Manuals;marginalization;Measures;men;Mental Depression;Mental Health;Methods;microaggression;mindfulness;mindfulness-based stress reduction;minority stress;model development;Modification;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Patient Self-Report;peer;Personal Satisfaction;Phase;Pilot Projects;pilot trial;Prevention;Prevention approach;Prevention program;Procedures;programs;protective factors;psychological distress;Public Health;public health relevance;Randomized;randomized trial;Recording of previous events;recruit;reduced alcohol use;Reporting;Research;Research Design;Resistance;revictimization;Risk;Risk Factors;Risk Reduction;risk sharing;Sampling;sexual assault;sexual coercion;sexual health intervention;sexual minority women;sexual victimization;sexual violence;skills;skills training;Social support;Strategic Planning;stress reduction;stressor;Structure;Surveys;Target Populations;Testing;therapy design;therapy development;Training;Trauma;university student;Violence;Waiting Lists;Woman;Women's Group;young adult

PROJECT_TITLE: Integrated Alcohol and Sexual Assault Prevention for Bisexual Women

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PI_NAMEs: BOWES RICKMAN, CATHERINE  (contact)

PROJECT_TERMS: Area;Cellular biology;Center Core Grants;Communities;Computer software;Dedications;Disease;experience;fluorescence imaging;Fostering;Gel;Goals;Health;Human Resources;imaging system;Individual;instrumentation;Laboratories;Mass Spectrum Analysis;Modernization;Molecular;Molecular Biology;next generation;Protein Analysis;Proteomics;Reader;Research;Research Personnel;Resource Sharing;Resources;Reverse Transcriptase Polymerase Chain Reaction;Scientist;Services;skills;small molecule;Structure;Techniques;Technology;tissue culture;Training;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Mass Spectrometry and Molecular Biology Module


PI_NAMEs: MALEK, GOLDIS  (contact)

PROJECT_TERMS: Animal Disease Models;Animal Model;Animals;Behavioral;Center Core Grants;Communities;Environmental Risk Factor;experience;Eye;Fostering;Generations;Genetic;Goals;Human Resources;Individual;instrumentation;Laboratories;member;Morphology;Nature;next generation;Operative Surgical Procedures;Pathology;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Surgical Equipment;Techniques;tool;Training;Vision;Vision research;vision science;visual performance;Visual System

PROJECT_TITLE: Animal Models Module


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The human cerebral cortex is greatly expanded compared to other primates, which is ultimately caused by genetic changes that affect gene expression regulation and how the human cerebral cortex develops. My goal is to reveal how a specific region of human-specific genetic change and human innovations in gene regulation shape cortical development and evolution, by using novel mouse models. This knowledge of how uniquely human genetic and developmental change affect growth of the cerebral cortex, an important structure for higher-order cognition, is crucial for understanding the etiology of disorders affecting humans, such as neurodevelopmental disorders and cognitive impairment.

PI_NAMEs: BAUMGARTNER, MARY  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;autism spectrum disorder;Binding;Bioinformatics;Brain;cell behavior;Cell Count;Cell Culture Techniques;Cell Cycle;cell type;Cells;Cerebral cortex;Cerebrum;ChIP-seq;Chromatin;chromosome conformation capture;Clinical;Cognition;Comparative Study;Data;Development;Developmental Gene;Disease;Embryo;Enhancers;Epigenetic Process;epigenetic profiling;Etiology;Event;Evolution;Exhibits;Fellowship;fetal;Foundations;functional genomics;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;Genes;Genetic;Genetic Transcription;Genome;genome-wide;global developmental delay;Goals;Growth;Heterogeneity;Higher Order Chromatin Structure;Histologic;histone modification;Human;human fetal brain;Human Genetics;humanized mouse;Impaired cognition;in vivo;innovation;Kinetics;Knockout Mice;Knowledge;Length;Link;Mediating;Methods;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;nerve stem cell;neural;Neurobiology;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;novel;Organoids;Orthologous Gene;overexpression;Pan Genus;Phenotype;Primates;Production;programs;Proliferating;Quantitative Reverse Transcriptase PCR;Radial;recruit;Regulation;Regulatory Element;Reporting;Repression;Research;Resolution;risk variant;Role;Shapes;Speed;stem cell fate;stem cell proliferation;stem cells;success;transcription factor;transcriptomics;Variant;Work

PROJECT_TITLE: Modeling gene regulatory mechanisms contributing to the evolution of the human cerebral cortex


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Narrative Cellular state changes generally require the simultaneous action of a handful of master regulators, substantially limiting the robust, durable, stable engineering of cell state for therapeutic application that can be achieved with current methods for modulating the expression of individual genes. We plan to move beyond the standard one- perturbation-per-gene paradigm for linking genes to phenotypes by engineering a platform for highly combinatorial cell state perturbation. We anticipate this platform, which combines both novel wetlab approaches for engineering highly combinatorial libraries producing a high multiplicity of perturbation with computational approaches to deconvolve these signals and iteratively engineer maximally informative libraries, will provide a match between the inherent polygenic complexity of cellular systems and our ability to rationally perturb these systems to elicit ideal therapeutically-relevant phenotypes.

PI_NAMEs: GREENLEAF, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Biological;biological systems;Cell Differentiation process;Cell Therapy;cell type;Cells;cellular engineering;Collaborations;combinatorial;Complex;design;Dominant-Negative Mutation;Engineering;Epigenetic Process;Gene Expression;Generations;Genes;Genetic;Genetic Screening;genome wide screen;Human;Human Biology;improved;Individual;Language;Libraries;Link;Logic;Machine Learning;Mammalian Cell;Methods;Modeling;novel;Phenotype;programs;Property;Proteins;regenerative;Regulatory T-Lymphocyte;Research;Sea;Signal Transduction;Structure;System;T-Lymphocyte;Therapeutic;tool;Toy;transcription factor;transdifferentiation;Vocabulary

PROJECT_TITLE: Combinatorial Cell State Engineering


PI_NAMEs: SABAN, DANIEL RAPHAEL (contact)

PROJECT_TERMS: cell preparation;cell type;Cells;Center Core Grants;Communities;Computer software;Data;data acquisition;Data Analyses;Equipment;experience;Flow Cytometry;Fostering;Individual;Laboratories;next generation;Pathology;Phenotype;Research;Research Personnel;Resource Sharing;Resources;Scientist;Specialist;Techniques;Tissues;Training;Vision;Vision research;vision science;Visual System

PROJECT_TITLE: Flow Cytometry Module


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: AUGUSTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Ammonia solution (20%) (AMM) is highly toxic and of interest to the CCRP, and the cornea is a major target for acute ammonia exposure. Corneal ammonia exposure results in an alkali burn wound, which can lead to a host of potentially blinding pathologic features and often times loss of the eye. The long-term objectives of this project are several fold, with the overall goals being to gain a better understanding of the mechanisms behind injuries created by corneal AMM exposure, and to develop potential therapeutics to treat AMM-induced wounds.

PI_NAMEs: HAMMOCK, BRUCE D;WATSKY, MITCHELL A (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acids;Acute;Adverse effects;Alkalies;Ammonia;analog;Anti-Inflammatory Agents;Blindness;burn model;burn wound;Cell Culture Techniques;Cell Death Induction;Cells;chemical stability;Cicatrix;clinical translation;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;Data;Defect;design;Development;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;epithelial wound;Epithelium;Epoxide hydrolase;Epoxy Compounds;Exposure to;Eye;Fatty Acids;Fibrosis;Fluorescein;Flushing;Goals;healing;histopathological examination;Human;human tissue;Hydration status;Immune;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory;inhibitor;Injury;interest;liquid chromatography mass spectroscopy;Liquid substance;Location;Mass Spectrum Analysis;Measures;Mixed Function Oxygenases;model development;Modeling;Mus;neovascularization;novel;Pathologic;Pathology;Pathway interactions;Phase Ia Trial;Polyunsaturated Fatty Acids;Prevention;Proteins;Reporting;response;response to injury;Role;Signal Pathway;Stains;Testing;Therapeutic;Therapeutic Uses;Time;tissue culture;Topical application;Ulcer;wound;wound healing;Wound models

PROJECT_TITLE: Soluble epoxide hydrolase and epoxide fatty acid involvement in corneal injury after ammonia exposure: Mechanisms of injury and potential therapeutics using sEH inhibitors and biostable EpFA mimics.


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative In order to impact patients through personalized medicine, we need better technologies for measuring proteins in clinical research. The development of targeted mass spectrometry methods will provide tools to meet this need, ushering in new information for studying disease mechanisms, diagnosing disease, and predicting response to therapy.

PI_NAMEs: WHITEAKER, JEFF  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Address;Analytical Chemistry;arm;Biological;Biological Assay;Biomedical Research;Clinical;clinical care;Clinical Research;Communities;Development;Diagnostic;disease diagnosis;disease mechanisms study;experience;Goals;improved;insight;Laboratories;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Methods;novel;Pathway interactions;Patients;personalized medicine;Post-Translational Protein Processing;Prediction of Response to Therapy;programs;Proteins;Proteomics;Reproducibility;Research;Resources;Role;Sampling;Specialist;Standardization;success;Technology;tool;Translating;translational oncology;Translations

PROJECT_TITLE: A proteomics research specialist in developing targeted mass spectrometry methods for quantifying proteins important in cancer


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Hematology;Patient Safety;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Blood clots that form in the arms and legs and travel to the lungs, or venous thromboembolism (VTE), are serious yet preventable. Tools are available to help clinicians in the hospital decide together with their patients whether to initiate VTE prevention, but these tools are too burdensome and cumbersome to be used reliably in daily clinical practice, and their use has not been shown to improve patient outcomes. Therefore, we will refine, implement, and test a highly accurate real-time prognostic model for VTEs among hospitalized adults that helps clinicians to initiate appropriate and timely VTE prevention, thereby reducing rates of VTE.

PI_NAMEs: FRENCH, BENJAMIN  (contact);MIXON, AMANDA SALANITRO

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adult;arm;Automobile Driving;Blood coagulation;Blood Coagulation Disorders;Calibration;Cessation of life;Clinical;clinical decision support;Clinical Informatics;Clinical Management;clinical practice;Coagulation Process;Collection;Communities;Computer software;Conceptions;Data;Data Science;Development;Discrimination;Disease;Dissemination and Implementation;Effectiveness;Electronic Health Record;Embolism;Ensure;Equity;Evaluation;evidence base;Exhibits;Failure;Goals;Heart Diseases;Hematological Disease;Hemorrhage;Hospitalization;Hospitals;implementation evaluation;implementation research;implementation science;implementation strategy;implementation tool;improved;Informatics;Infrastructure;innovation;Inpatients;Institute of Medicine (U.S.);Interdisciplinary Study;interest;Intervention;Interview;Judgment;Knowledge;Leg;Limb structure;Lung;Lung Diseases;machine learning method;Manuals;Measures;Medical Errors;Medical History;member;Methodology;model development;Modeling;Morphologic artifacts;multidisciplinary;multiple data types;National Heart, Lung, and Blood Institute;Needs Assessment;open source;Outcome;Output;patient subsets;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized risk prediction;pragmatic randomized trial;Predictive Analytics;predictive modeling;predictive tools;preference;prevent;preventable death;Prevention;Probability;prognostic model;Prophylactic treatment;prospective;Provider;provider communication;Qualitative Methods;Randomized;Randomized, Controlled Trials;Recording of previous events;Reproducibility;Research;Resources;response;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction model;risk stratification;Sleep Disorders;Statistical Methods;support tools;System;Testing;Time;tool;Travel;treatment as usual;Update;uptake;user-friendly;venous thromboembolism;Visualization;Work;Workload

PROJECT_TITLE: Optimizing the implementation of personalized risk-prediction models for venous thromboembolism among hospitalized adults

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Cytochrome filaments with closely stacked hemes were just recently discovered by us to be responsible for long- range electron transfer. These novel conductive nanowires have great potential as biomedical materials, yet much is still unknown about their mechanism of action and biophysical properties. This proposal aims to identify novel cytochrome filaments in respiring prokaryotes, elucidating their conduction mechanism by biophysical approaches, and designing self-assembled nanowires for biomedical applications.

PI_NAMEs: WANG, FENGBIN  (contact)

PROJECT_TITLE: Understanding and using microbial conductive nanowires


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Emergency Care;Health Services;Heart Disease;Neurosciences;Prevention

PHR: Project Narrative In the United States, approximately 350,000 people suffer out-of-hospital cardiac arrest per year, and there is an urgent need to generate evidence on how to integrate effective treatments into a coordinated system of care at the community and state levels. Our study will test a customized strategic intervention program that focuses on community interventions to improve key process of care measures in the critical minutes after cardiac arrest. If successful, our intervention would provide a roadmap for communities throughout the United States to save lives and improve patient outcomes after cardiac arrest. 1

PI_NAMEs: GRANGER, CHRISTOPHER B. (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: American Heart Association;Cardiopulmonary Resuscitation;Cardiovascular Agents;cardiovascular emergency;care systems;Caring;Categories;Cerebrum;Clinical;Clinical Research;Clinical Trials;cluster randomized design;Cluster randomized trial;Collaborations;Communities;community intervention;comparison control;comparison intervention;Country;County;Data Collection;Data Coordinating Center;design;Devices;Doctor of Philosophy;effective intervention;effective therapy;Electric Countershock;Elements;Emergency Care;Emergency medical service;Emergency response;Enrollment;first responder;functional status;Goals;Heart Arrest;Heterogeneity;Hospitals;implementation intervention;implementation measures;implementation trial;improved;improved outcome;Infrastructure;Institute of Medicine (U.S.);Instruction;Intervention;intervention program;Investments;Link;Measures;Medical;Medical emergency;Medicine;Modernization;National Heart, Lung, and Blood Institute;Nervous System Physiology;Neurologic;Neurological outcome;North Carolina;Observational Study;out-of-hospital cardiac arrest;Outcome;Paramedical Personnel;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;Population Density;Principal Investigator;Process;Protocols documentation;Provider;Public Health;Quality of life;Race;Randomized;randomized trial;Refractory;Registries;Reporting;Research;Research Institute;Resources;response;Resuscitation;service intervention;Signal Transduction;Socioeconomic Status;standard care;statistics;Structure;Survival Rate;System;Telephone;telephone coaching;Testing;Training;Training Activity;treatment as usual;trial design;United States;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: RACE-CARS CCC 1/2

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Biotechnology;Kidney Disease

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE. I propose to evaluate the role of lipotoxic ceramides in the tubular epithelium as mediators of metabolic dysfunction driving kidney injury. Successful completion of this work will uncover novel kidney-specific mechanisms driving kidney injury pathogenesis and progression. Additionally, we intend for these studies to inform future investigations into novel therapeutic targets for acute kidney injury and disease in order to improve patient care, decrease risk of morbidity and mortality, and lessen the substantial economic burden of acute kidney injury.

PI_NAMEs: NICHOLSON, REBEKAH JOY (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Aerobic;Albumins;Anabolism;Animals;Apoptosis;Apoptotic;Automobile Driving;Bilateral;Binding;Bioenergetics;career;Cell Culture Techniques;cell type;Cells;Ceramides;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinical;combat;cytokine;Data;Data Correlations;Development;Diabetic Nephropathy;Disease;disease model;Disease Outcome;Disease Progression;Doxycycline;driving force;Economic Burden;Electron Transport;Enzymes;Epithelial Cells;Epithelium;Evaluation;Event;Exposure to;fatty acid oxidation;Fatty Acids;Fellowship;Filtration;Functional disorder;Future;Genes;Genetic;Glomerular Filtration Rate;Goals;Healthcare;Histopathology;Human;human model;impaired driving performance;Impairment;improved;In Vitro;Inflammatory;inhibitor;injured;Injury;Injury to Kidney;insight;Intervention;Investigation;Kidney;Kidney Diseases;kidney dysfunction;kidney fibrosis;kidney metabolism;Knowledge;lipid metabolism;Lipids;LoxP-flanked allele;Mass Spectrum Analysis;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;nephrogenesis;Nephrology;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;novel therapeutic intervention;overexpression;Oxidative Stress;Oxygen Consumption;Pathogenesis;Pathology;Pathway interactions;Patient Care;Patients;Play;Pre-Clinical Model;pre-doctoral;preclinical study;preference;prevent;Principal Investigator;Process;Production;Proximal Kidney Tubules;Reactive Oxygen Species;Renal function;renal ischemia;Renal Tissue;Renal tubule structure;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Respiration;Risk;Rodent;Role;Running;Scientist;serine palmitoyltransferase;single-cell RNA sequencing;solute;Sphingolipids;stable isotope;System;Technical Expertise;Testing;Therapeutic;therapeutic candidate;therapeutic target;Tissues;Training;Transgenic Animals;Transgenic Mice;Transgenic Organisms;Tubular formation;uptake;Ureteral obstruction;Work

PROJECT_TITLE: Ceramides as Novel Mediators of Tubular Metabolic Dysfunction Driving Kidney Injury


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Osteoporosis;Physical Activity;Prevention

ORG_DEPT: MISCELLANEOUS

ORG_NAME: WAKE FOREST UNIVERSITY

PHR: PROJECT NARRATIVE Identification of intervention strategies to minimize dietary weight loss associated bone loss among older adults is needed. This R01 will compare the independent and combined effects of progressive resistance training plus bone loading exercises and bisphosphonate use on measures of bone density, quality, and turnover in 392 older adults who are undergoing a dietary weight loss intervention. If confirmed to be effective, evidence has the potential to shift current geriatric obesity treatment guidelines and enhance scientific understanding of mechanisms governing treatment response.

PI_NAMEs: BEAVERS, DANIEL P;BEAVERS, KRISTEN MARIE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Acceleration;Acute;Address;Adjuvant;Adult;adult obesity;Aerobic Exercise;Affect;Alendronate;Biological Markers;bisphosphonate;Body mass index;Body Weight decreased;bone;Bone Density;bone loss;bone mass;bone metabolism;bone preservation;bone quality;Bone remodeling;Bone Resorption;bone turnover;capsule;Clinical;Clinical Research;Colorado;Combined Modality Therapy;Data;dietary;Distal;Effectiveness of Interventions;Elderly;Exercise;exercise prescription;FDA approved;Fracture;fracture risk;Hip region structure;insight;Intervention;Knowledge;Literature;Measures;mechanical load;Mediating;Medical;Metabolic;Metabolism;novel;Obesity;obesity treatment;older adult;Operative Surgical Procedures;Oral;Osteoclasts;Osteoporosis;osteoporosis with pathological fracture;osteoprotective;Outcome;Participant;Pathway interactions;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Placebos;Population;Porosity;post intervention;preservation;prevent;primary outcome;Radial;Randomized;Randomized, Controlled Trials;Recommendation;resistance exercise;Resolution;Risk;Roentgen Rays;Role;Safety;Secondary to;Signal Transduction;Site;skeletal;sobriety;substantia spongiosa;Testing;Thick;tibia;treatment effect;Treatment Efficacy;treatment guidelines;treatment response;Universities;Weight;weight loss intervention;X-Ray Computed Tomography

PROJECT_TITLE: Exercise and Bisphosphonate Use to Minimize Weight Loss Associated Bone Loss among Older Adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Lung;Mucopolysaccharidoses (MPS);Orphan Drug;Rare Diseases

PHR: PROJECT NARRATIVE  There are millions of people who suffer from different rare diseases worldwide, and many of those diseases lack treatment options that are safe, effective, and convenient for patients. The proposed research will explore a path towards a treatment that meets those requirements using adenovirus as a vessel to deliver gene therapy for a rare disease called mucopolysaccharidoses type I (MPS I). This work will therefore attempt to deliver the corrective gene to cells within the mouse model for MPS I and provide critical information on the feasibility and future possibilities of the use of adenovirus for treatment of rare diseases.

PI_NAMEs: HURT, SARAH  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Address;adenoviral mediated;Adenovirus Vector;Adenoviruses;Affect;Alternative Therapies;Antibodies;Binding;Biochemical;Biological Assay;Blood Circulation;Body System;Capsid;cell type;Cells;Cellular Morphology;Cessation of life;Clinical;Clinical Trials;Consumption;cost;CRISPR/Cas technology;design;Developmental Delay Disorders;Disease;Dose;Elements;Employment;Endothelial Cells;Endothelium;enzyme activity;enzyme replacement therapy;Enzymes;Face;Fiber;Financial cost;Future;gene editing technology;gene therapy;Gene Transduction Agent;gene transfer vector;gene-editing approach;Genes;Genetic Diseases;Genome;Glycosaminoglycans;Goals;Heart Diseases;Hepatotoxicity;Histologic;Immune response;Immune system;improved;in vivo;Individual;Infection;Inherited;interest;intravenous administration;L-Iduronidase;Life Expectancy;Liver;loss of function;Loss of Heterozygosity;Lung;Lysosomes;manufacture;Mendelian disorder;Methods;Modeling;Modification;Molecular;mouse model;Mucopolysaccharidosis I;Mucopolysaccharidosis I S;Mutation;Myelogenous;Newborn Infant;Oncogenic;Open Reading Frames;Outcome;Outcome Assessment;Patients;Peptides;Persons;Phenotype;physical symptom;Production;Pulmonary Heart Disease;Rare Diseases;Recovery;repaired;Research;Respiratory Tract Infections;Risk Reduction;Role;Serum;Severities;Source;Structure;Symptoms;System;Time;transgene expression;Tropism;Variant;Vascular Endothelium;vector;Viral Vector;Virus;Work;X-linked myotubular myopathy

PROJECT_TITLE: Pulmonary endothelium targeted adenoviral gene therapy for the correction of mucopolysaccharidosis type I


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Frailty is a syndrome of reduced physiologic reserve associated with higher postoperative death and complications. While there is global consensus on identifying frail or high-risk patients prior to surgery, less is known on how to intervene in their clinical care to improve outcomes while respecting their goals and expectations. The PAUSE trial is a cluster randomized clinical trial to explore the overall effectiveness (Aim 1), and effectiveness by specialty, frailty and risk status (Aim 2) of implementing a multidisciplinary care model (surgery, anesthesia, geriatrics, palliative care, case management, rehabilitation and nutrition) for surgical decision-making and optimization of postoperative outcomes. We will study the fidelity, adaptation, and implementation of the PAUSE intervention (Aim 3) to develop an implementation guide. Our overall goal is to disseminate the PAUSE intervention for future implementation in the VA as a new model for care of high-risk Veterans being evaluated for surgery.

PI_NAMEs: ARYA, SHIPRA  (contact)

PROJECT_TERMS: Adoption;adverse outcome;Affect;aged;Aging;Anesthesia procedures;Blood Vessels;budget impact;Caring;Case Management;Cessation of life;Clinic;Clinical;clinical care;Clinical effectiveness;Clinical Trials Design;cohort;Collection;Complex;Consensus;Consolidated Framework for Implementation Research;contextual factors;cost;Data;Data Analyses;Decision Making;Development;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;effectiveness/implementation study;Evaluation;expectation;experience;Factor Analysis;formative assessment;frailty;Funding Mechanisms;Future;future implementation;Geriatrics;Goals;health care service utilization;Healthcare;Heterogeneity;high risk;Home;Hospice Care;Hospice Programs;hospital readmission;Hospitalization;Hybrids;implementation framework;implementation intervention;improved;improved outcome;indexing;innovation;Institution;Institutionalization;Intervention;Intervention Trial;Interview;Knowledge;Life;Long-Term Care;Measures;medical specialties;Methodology;Methods;Minor Surgical Procedures;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Nature;Needs Assessment;neurosurgery;novel;nutrition;Office Surgery;Oncology;Operative Surgical Procedures;Orthopedics;Outcome;Palliative Care;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;perioperative mortality;Physiological;Plastics;Population;post intervention;Postoperative Period;Primary Care;Process;programs;Provider;Quality of life;randomized, clinical trials;Recommendation;Rehabilitation therapy;Research Design;Research Methodology;Research Personnel;Resources;Risk;risk mitigation;Schedule;screening;Severities;Site;Site Visit;Specialist;Structure;surgery outcome;Surgical Models;Syndrome;System;tertiary care;Testing;Time;treatment as usual;treatment effect;uptake;Urology;Use Effectiveness;Veterans;Work;wound care

PROJECT_TITLE: PAtient-centered mUltidiSciplinary care for vEterans undergoing surgery (PAUSE): a hybrid 1 clinical effectiveness-implementation intervention trial

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative The development of feasible, effective and scalable interventions to improve the safety of patients at risk for or with central line-related bloodstream infections, is urgently needed. The proposed Johns Hopkins Center for Immersive Learning and Digital Innovation (CILDI) will advance the science of patient safety through a sustainable infrastructure that will test innovative interprofessional interventions co-designed with individuals and families experiencing these conditions. CILDI will utilize a framework comprising a systems engineering initiative for patient safety model and the AHRQ systems engineering project life cycle, to measure patient safety and process efficiency in order to increase the relevance, uptake and sustainability of the interventions.

PI_NAMEs: PANDIAN, VINCIYA  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Center for Immersive Learning and Digital Innovation: A Patient Safety Learning Lab advancing patient safety through design, systems engineering, and health services research

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_NAME: VA SALT LAKE CITY HEALTHCARE SYSTEM

PHR: The growing prevalence of Alzheimer’s disease (AD) and its preliminary stage, mild cognitive impairment (MCI), among U.S. Veterans has stimulated efforts to identify therapeutic targets to modify the progression of these debilitating, neurodegenerative diseases. Recent evidence suggests that dysfunction of the vascular endothelium and decreased abundance of its product, nitric oxide (NO), may contribute to the production and accumulation of neurotoxins thought to cause AD, making endothelial NO bioavailability a potential therapeutic target for the treatment of AD. Therefore, the purpose of this study is to determine if endothelial function and cerebral NO bioavailability are related to the severity and longitudinal progression of AD. Ultimately, these findings will help determine if endothelial function may serve as a prognostic indicator, as well as a potential therapeutic target, in the fight against AD.

PI_NAMEs: RICHARDSON, RUSSELL S. (contact)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease patient;amnestic mild cognitive impairment;Amyloid beta-Protein;Animals;atherogenesis;Attenuated;Biological Availability;Blood flow;brachial artery;Cerebral endothelium;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Clinical;Cognitive;cognitive control;cognitive function;Core-Binding Factor;Diameter;Disease;disease phenotype;Disease Progression;Doppler Ultrasound;Economic Burden;endothelial dysfunction;Endothelium;Exhibits;experience;fighting;Goals;Hyperemia;Impaired cognition;in vivo;Intravenous infusion procedures;Leg;Link;Measurement;Measures;Mediating;Medical;Metabolic;middle cerebral artery;mild cognitive impairment;Movement;Neurodegenerative Disorders;neurotoxic;Neurotoxins;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthetase Inhibitor;omega-N-Methylarginine;Pathology;Patients;Peripheral;Play;Prevalence;Production;prognostic indicator;Protein Fragment;rate of change;Rest;Role;Severities;Severity of illness;sex;social;targeted treatment;therapeutic target;Time;vascular abnormality;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Veterans

PROJECT_TITLE: Vascular Endothelial Function: A Potential Therapeutic Target in Alzheimer's Disease

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE: OVERALL CORE To advance the field of child abuse and neglect, a diverse and transdisciplinary team comprised of researchers, staff, consultants, and National Advisory Board with leaders from the Universities of Rochester and Minnesota will partner with the NICHD to enhance and expand the TRANSFORM Center (Translational Research that Adapts New Science FOR Maltreatment Prevention). Building on current state-of-the-art research methodologies and clinical practices that address the personal and societal burden associated with child abuse and neglect, TRANSFORM will continue to leverage theoretically-grounded evidence-based research and interventions to optimize outcomes in children. A broad audience of investigators, child-serving professionals, parental, and governmental stakeholders will be the target audiences for community engagement, dissemination, and outreach activities.

PI_NAMEs: CICCHETTI, DANTE CICCHETTI;TOTH, SHEREE LYNN (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: acceptability and feasibility;Address;Adolescence;Adult;analytical method;Applied Research;Basic Science;Black race;career;career development;caregiving;Characteristics;Child;Child Abuse and Neglect;Child Welfare;Childhood;clinical practice;cohort;Communities;community engagement;Consensus;court;Development;Discipline;Education;emerging adulthood;Environment;Etiology;evidence base;Evidence based program;Evidence based treatment;experience;Experimental Designs;Family;Family health status;Fostering;Foundations;Genetic;Geography;Goals;graduate student;Grant;Gynecologic;Health;implementation science;improved;Individual;Informal Social Control;innovation;Interdisciplinary Study;intergenerational;International;Interpersonal Relations;Intervention;Intervention Studies;Investigation;investigator training;Laboratories;Leadership;Life Cycle Stages;Long-Term Effects;longitudinal database;maltreatment;Measurement;Mental Health;Methodology;Methods;Minnesota;minority investigator;Modeling;National Institute of Child Health and Human Development;Neurosciences;next generation;offspring;Outcome;outreach;physical conditioning;Pilot Projects;Policies;Policy Maker;Population;Postdoctoral Fellow;prevent;Prevention;Principal Investigator;Process;programs;prospective;Provider;Psychopathology;Quality Control;racial identity;Recording of previous events;Reproductive Health;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk;Science;Scientist;service providers;Severities;social;Societies;Solid;success;System;Testing;therapy design;Training;Translational Research;Underrepresented Minority;United States;Universities;Virginia;Work;Youth

PROJECT_TITLE: Translational Research that Adapts New Science FORMaltreatment prevention (TRANSFORM)


PI_NAMEs: TOTH, SHEREE LYNN (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Child Abuse and Neglect Research;Pediatric;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: HANDLEY, ELIZABETH DIPAOLA (contact)

PROJECT_TERMS: analytical method;Applications Grants;archived data;Archives;career;Child Abuse and Neglect;Clinic;cohesion;Collaborations;Communities;Consultations;cost;cost effectiveness;Data;Data Analyses;Data Analytics;data archive;data infrastructure;data integration;data management;data quality;Data Set;data sharing;Data Sources;Development;Developmental Process;experience;Faculty;Family;Family health status;Fostering;Goals;health service use;Individual;Infrastructure;Intervention;Lawyers;Lead;Leadership;Legal;Longitudinal cohort study;longitudinal design;Measurement;Mentors;Mentorship;Methodology;Methods;Mission;Modeling;Navigation System;next generation;non-compliance;outreach;participant retention;Pilot Projects;Police;Positioning Attribute;Prevention;Prevention Research;preventive intervention;Productivity;prospective;Psychopathology;Publishing;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;resilience;Resources;Risk;Role;Science;Services;Site;skills;Statistical Methods;synergism;System;Training;Translational Research;Youth

PROJECT_TITLE: Resource Core


NIH_SPENDING_CATS: Clinical Research

PROJECT_TITLE: Long-term and multigenerational impact of child abuse and neglect on health


ORG_CITY: PHOENIX

ORG_NAME: INTER TRIBAL COUNCIL OF ARIZONA, INC.

ORG_STATE: AZ

PHR: NARCH XI - American Indian Research Center for Health Overall Narrative The ITCA American Indian Research for Health (AIRCH) was established in 2000 to reduce health disparities among American Indians and Alaska Natives by engaging tribes in research that is scientifically sound. ITCA works to improve the capacity of tribes in Arizona, including areas related to health. With over 70 staff and 30 projects, ITCA provides on-going technical assistance and over 100 annual trainings to Tribes in program planning and development, research and data collection, and resource development. The AIRCH XII overall goal is to support health research projects that benefit Tribal communities of the ITCA Member Tribes, develop relationships to enhance tribal governance and partnerships in health research, conduct research that honors Tribal Sovereignty, and promote a cadre of AI/AN researchers in health disparities research. Along with the proposal, the AIRCH supports research capacity building and the development of research infrastructure to enhance the biomedical research capabilities of the 21 Member Tribes.

PI_NAMEs: DADGAR, MARIA  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Address;Alaska Native;American Indians;Area;Arizona;Biomedical Research;Collaborations;Communities;community based participatory research;community research;Credentialing;Data;Data Collection;Development;Education;Educational Curriculum;Ensure;Ethics;experience;Faculty;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;improved;Indigenous;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Leadership;Medical center;member;Methods;Mission;Native American Research Center for Health;outreach program;Pathway interactions;Policy Maker;Population;Procedures;Program Development;programs;Public Health;Reduce health disparities;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Development;Resources;Risk;Services;skill acquisition;social;sound;STEM field;Students;success;System;Technology;tool;Training;Translating;tribal community;tribal member;tribal Nation;Tribes;Trust;Universities;Work

PROJECT_TITLE: ITCA NARCH 12 Grant


NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Violence Research

PI_NAMEs: STURGE-APPLE, MELISSA L (contact)

PROJECT_TERMS: 12 year old;20 year old;Address;Adolescence;Adult;barrier to care;base;Black Populations;Black race;Characteristics;Child;Child Abuse and Neglect;Child Rearing;Child Welfare;Clinical;clinical practice;community violence;coping;Coping Skills;Data Collection;dehydroepiandrosterone;design;Development;Dimensions;Discrimination;early adolescence;emerging adulthood;experience;Family;Family Characteristics;Friends;health care availability;Heterogeneity;Individual;Individual Differences;Inequity;informant;interpartner violence;Interview;Knowledge;Latinx;Latinx population;Life Experience;Link;Literature;marginalization;Measurement;Measures;Mediating;Meta-Analysis;Methodology;Methods;Modeling;Nature;Neurobiology;Neurocognitive;Neurosecretory Systems;offspring;older adult;Parent-Child Relations;Parents;Participant;Pathway interactions;peer;perceived discrimination;Policies;Prevention;primary caregiver;Process;Professional counselor;prospective;psychologic;Psychopathology;Public Health;Public Policy;Q-Sort;Research;Risk Factors;Role;Sampling;Science;social;social skills;Social support;Solid;sound;Source;Structure;Surveys;Testing;Training;Translational Research;Translations

PROJECT_TITLE: Adult Relationship Sequelae of Child Abuse and Neglect: Multiple Developmental Cascades


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Substance Misuse

PHR: NARCH XII Administrative Core Narrative The Inter Tribal Council of Arizona, Inc. (ITCA), is a tribally controlled non-profit organization established in 1975. ITCA has the goal of promoting American Indian self-reliance through public policy development, and to provide Member Tribes with the means for action on matters that affect them collectively and individually. The Member Tribes of ITCA are 21 federally-recognized Tribes located in the State of Arizona. The highest elected official of each Member Tribe serves on the council. These leaders have a comprehensive view of the conditions and needs of the tribal communities they represent. ITCA provides an independent capacity to obtain, analyze, and disseminate information vital to tribal community self-development. To build upon the ethical approach of research among the tribal communities, and continue a long- standing relationship with The University of Arizona and Arizona State University in creating a space for developing AI/AN science focused students and faculty. ITCA proposes to provide the infrastructure for the Native American Research Centers for Health (NARCH) projects as the Administrative Core ensuring all rules and regulations of the award are delivered, along with efficient communication providing accountability of NARCH oversight.

PI_NAMEs: LANE, TRAVIS  (contact)

PROJECT_TERMS: Accident and Emergency department;Accountability;Address;Advocate;Affect;Agreement;Alaska Native;American Indian community;American Indians;Archives;Arizona;Arthropod Vectors;Award;career;catalyst;Collaborations;Communication;Communities;community based participatory research;community based research;community research;Data;Data Collection;Development;Education;Elements;Ensure;Environmental Health;Ethics;Evaluation;Faculty;Future;Goals;Grant;Guidelines;Health;health disparity;Health Sciences;Hospitals;human subject protection;improved;Indigenous;indigenous community;Individual;Infrastructure;innovation;Institution;interest;intertribal;Isotopes;Knowledge;manufacture;Mass Spectrum Analysis;Mentorship;Methods;Mission;Native American Research Center for Health;new technology;Nonprofit Organizations;outreach program;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pilot Projects;Policy Developments;Policy Maker;Process;programs;Psychiatric Diagnosis;Public Health;Public Policy;Recording of previous events;Regulation;Relationship-Building;Research;Research Ethics;Research Personnel;Research Project Grants;Resolution;Resource Development;Resources;Rights;risk perception;Role;Science;Self Determination;self reliance;Source;STEM field;Students;Substance Use Disorder;success;tool;Training;tribal community;Tribal Council;tribal member;tribal Nation;Tribes;United States;Universities;vector;Vector-transmitted infectious disease

PROJECT_TITLE: ITCA NARCH 12 Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Substance Misuse

PI_NAMEs: CARROLL, STEPHANIE RUSSO (contact)

PROJECT_TERMS: Address;Arizona;career;Case Study;cohort;Communities;community based research;Community of Practice;Consultations;Data;Data Science;Discipline;early-career faculty;Educational Curriculum;Equity;Ethics;Faculty;Fostering;Foundations;Future;Goals;Grant;Health;Indigenous;indigenous community;innovation;Institution;interest;International;intertribal;Knowledge;Laws;Learning;Link;meetings;Mentors;Modeling;Movement;Native American Research Center for Health;open data;pedagogy;Persons;Policies;programs;Protocols documentation;Public Sector;Publications;Recommendation;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;Rights;Science;Specimen;Students;synergism;tool;Training;tribal college;tribal community;Tribal Council;tribal leader;tribal Nation;Tribally Based Participatory Research;Tribes;United Nations;Universities;webinar;Work

PROJECT_TITLE: UA CE Project: Enhancing Early Career Research Ethics to Support Indigenous Research Governance


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Despite the initial responses to molecular-targeted therapies, many cancer patients experience disease recurrence, because cancer stem cells (CSCs) are refractory to these treatments with largely unknown mechanisms. This project will identify new genes/pathways (i.e., FTO-m6A-lncRNAs) regulating CSC persistence, and test novel strategies (i.e., inhibiting FTO-m6A-lncRNAs to restore drug sensitivity) to eliminate CSCs. The findings will propel the design of new treatment options to achieve treatment-free remission improving cure rates and survival.

PI_NAMEs: HUANG, GANG ;LIU, SHUJUN  (contact);TSE, WILLIAM W

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Address;advanced disease;Biological Markers;cancer drug resistance;Cancer Patient;cancer stem cell;CD44 gene;cell growth;Cell Survival;Cells;clinical biomarkers;clinical translation;Critical Pathways;demethylation;design;Development;differential expression;Disease;Disease Progression;Disease remission;drug maintenance;Drug resistance;drug sensitivity;Engraftment;epitranscriptomics;experience;fat mass and obesity-associated protein;gain of function;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;IL2RA gene;Impairment;improved;inhibitor;inhibitor therapy;innovation;knock-down;Knowledge;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;Link;loss of function;Malignant Neoplasms;Methylation;methylome;Modeling;Modification;Molecular;molecular targeted therapies;mouse model;Mus;new therapeutic target;novel;novel strategies;Outcome;Pathway interactions;patient response;Patients;pharmacologic;Positioning Attribute;pre-clinical;Process;Proliferating;Protein Tyrosine Kinase;Proto-Oncogene Protein c-kit;Recurrent disease;Refractory;refractory cancer;Regimen;Regulation;Research;Resistance;Resistance development;response;RNA;Role;self-renewal;Signal Transduction;Source;stem cell biomarkers;stem cell fate;stem cell function;stem cell self renewal;stemness;targeted treatment;Testing;Therapeutic;Translational Research;Treatment Efficacy;Treatment Failure;treatment strategy;tumor progression;Tyrosine Kinase Inhibitor;Untranslated RNA;Up-Regulation;Work

PROJECT_TITLE: Role of an Aberrant N6-Methyladenosine-LncRNA Axis in the Development and Maintenance of Drug Resistance through Regulating the Leukemia Stem Cell