NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BATON ROUGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: Project Narrative  Health disparities exist for children who live in the Deep South, and these include inequities in our understanding of Developmental Language Disorder (DLD) in children who speak various nonmainstream dialects of English and in the materials and methods used to identify and treat children within DLD within these dialects. Using an innovative Disorder within Dialects framework, the proposed studies seek to further test a sentence recall task targeting tense and agreement (T/A) for its diagnostic accuracy and theoretical basis by expanding the type of child profile studied, examining the T/A structures in various syntactic frames, testing the nature of the scoring, and conducting several across-dialect and dialect-specific analyses of the data. The findings will advance our understanding of DLD within various dialects of English and move us one step closer toward developing dialect-appropriate and diagnostically accurate assessments, which should help reduce health disparities in children who live in the Deep South and elsewhere.

PI_NAMEs: MCDONALD, JANET L;OETTING, JANNA B (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;African American;African American population;Agreement;Area;Assessment tool;Case/Control Studies;Child;Child Rearing;Childhood;Clinical;clinical practice;Communities;Data;Data Analyses;Deep South;Development;Diagnostic;diagnostic accuracy;Diagnostic tests;Disease;Disparity;disparity reduction;Exclusion;first grade;Fright;Funding;Grant;health disparity;health disparity populations;Heterogeneity;individualized medicine;Inequity;innovation;Intelligence;kindergarten;Language;Language Development Disorders;Language Disorders;Linguistics;Mainstreaming;Memory;Methods;National Institute on Deafness and Other Communication Disorders;Nature;non-verbal;novel;Outcome;phonology;Play;Population;Psycholinguistics;recruit;Reduce health disparities;Research;Rural;Sampling;Short-Term Memory;Strategic Planning;Structure;suburb;syntax;System;Testing;United States National Institutes of Health;Variant;Vocabulary;Work

PROJECT_TITLE: Disorder within Dialects: An Expanded Test of Tense and Agreement in Sentence Recall for Children with DLD


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cachexia;Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Muscle cachexia is a debilitating syndrome that has a dramatic impact on survival and quality of life of many cancer patients and remains a poorly explored area. We believe that achievement of this research program to validate the role of Transglutaminase 2 in cancer-driven muscle cachexia will lead to a paradigm shift, both in terms of understanding the etiology of muscle cachexia, and in terms of drug discovery to curb this life-threatening comorbidity.

PI_NAMEs: ATFI, AZEDDINE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Achievement;activin A;Advanced Malignant Neoplasm;Affect;Area;Cachexia;Cancer Cachexia;Cancer Patient;carcinogenesis;Cells;Cessation of life;clinically relevant;combat;combinatorial;comorbidity;Complex;Complication;Coupled;crosslink;Data;Defect;design;Development;Diagnosis;Disease;Dose;drug candidate;drug discovery;Drug Targeting;Drug toxicity;Ectopic Expression;effective therapy;Enzymes;Etiology;experimental study;FBXO32 gene;Functional disorder;Gene Expression;Genetic;genetic approach;Glutamine;Impairment;improved;in vivo;Incidence;Individual;inhibitor;innovation;Knowledge;Life;Lysine;Malignant Neoplasms;Mediating;Medical;Medicine;Metabolic;Modeling;Modification;mouse model;Muscle;muscle progenitor cell;Muscle Proteins;Muscle Weakness;Muscular Atrophy;novel;Organ;pancreatic cancer patients;pancreatic ductal adenocarcinoma model;Pathway interactions;Patients;pharmacologic;Play;Predisposition;Process;Prognostic Marker;programs;promoter;protective effect;protein degradation;Quality of life;Reporting;Research;Research Proposals;Resistance development;Respiratory Failure;Role;skeletal;Syndrome;Testing;Therapeutic;therapeutic evaluation;transcription factor;transglutaminase 2;Treatment-Related Cancer;tumor progression;Tumor-Derived;ubiquitin ligase;Wasting Syndrome;Weight

PROJECT_TITLE: Targeting Transglutaminase 2 in cancer cachexia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Auburn

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative: Uncovering the molecular mechanisms controlling cell motility will facilitate the development of new therapeutic strategies aimed at enhancing the efficiency of stem cell therapies, promoting wound healing, or preventing diseases, including cancer metastasis. Although migrating cells can adapt to physical signals imposed by the local microenvironment, the impact of these cues on the mechanisms of cell locomotion remains unclear. We will herein employ an interdisciplinary approach to elucidate how pressure forces influence migration mechanisms and cell behavior in physiological microenvironments.

PI_NAMEs: MISTRIOTIS, PANAGIOTIS  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Affect;Aging;Biochemical;Cardiovascular Pathology;cell behavior;Cell Death;cell motility;Cell Survival;Cells;Computer Simulation;Cues;Development;Disease;Disease Progression;Environment;Event;experience;Exposure to;Goals;in vivo;interdisciplinary approach;interstitial;Invaded;Malignant Neoplasms;mechanical signal;microdevice;migration;Molecular;Neoplasm Metastasis;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;optogenetics;organ growth;Physiological;Play;Postdoctoral Fellow;pressure;prevent;Regulation;Role;shear stress;Signal Transduction;stem cell therapy;tissue regeneration;tool;transcriptomics;viscoelasticity;Work;wound healing

PROJECT_TITLE: Cell mechanoresponses in physiologically relevant microenvironments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The goal of this project is to explore the usefulness of a new molecule, RP-115, to measure inflammation and changes to astrocyte cells in the brains of people with Alzheimer's disease (AD). EAAT2, the target of RP-115, expressed abundantly by brain astrocytes, declines sharply in regions of the brain affected by AD. We believe that the use of positron emission tomography (PET) scanning to map radioactive RP-115 binding in AD patient brains will provide insight into the role of inflammation in early AD.

PI_NAMEs: GERDES, JOHN M;VANBROCKLIN, HENRY F.;WILSON, DAVID M (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Animals;aquaporin 4;Astrocytes;Binding;Blood;Blood specimen;Brain;Brain Mapping;Brain region;Cells;Cerebrum;Clinic;Clinical;Clinical Protocols;Clinical Research;Cognitive;cohort;Coupled;Data;Data Analyses;Development;dimer;Disease Progression;Dose;dosimetry;Evaluation;Excitatory Amino Acid Transporter 2;Family;Female;first-in-human;fluorodeoxyglucose;Functional disorder;Funding;Glucose Transporter;Glutamate Transporter;Glutamates;Glycoproteins;Goals;Homeostasis;Human;hyperphosphorylated tau;Image;imaging biomarker;imaging modality;Impaired cognition;Inflammation;Inflammatory Response;insight;Institutional Review Boards;interest;Investigational Drugs;Investigational New Drug Application;Label;Literature;Location;Magnetic Resonance Imaging;male;Maps;Measures;Membrane;Membrane Proteins;Memory;Methods;Modeling;Monoamine Oxidase B;Neuroglia;neuroinflammation;neurotransmitter uptake;New Drug Approvals;novel;Onset of illness;Organ;Pathology;Patient Recruitments;Patients;Persons;Play;Positron-Emission Tomography;postsynaptic neurons;presynaptic neurons;Proteins;Protocols documentation;Public Health;Radioactive;radioligand;radiotracer;Reporting;Role;Safety;safety study;Scanning;Synapses;Synaptic Vesicles;Testing;Therapeutic Intervention;Time;Tracer

PROJECT_TITLE: First-in-Human evaluation of an astrocytic glutamate transporter (EAAT2) PET tracer in healthy and Alzheimer's diseased brain


ADMINISTERING_IC: NR

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Billions of dollars are spent annually on health care for children, yet little is known about how early life experience affects children’s cellular aging. The proposed study examines the influence of early life experience on cellular aging across the first years of life. Findings from this study will help inform and guide actions regarding children’s health outcomes.

PI_NAMEs: GARRETT-PETERS, PATRICIA  (contact);SHALEV, IDAN

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: Acceleration;Address;Adult;African American;Age;age acceleration;aging clocks;aging mechanism;aging related;Behavioral;Biological;Biological Aging;Biological Assay;Biological Markers;Biology;Brain;burden of illness;Cell Aging;Cells;Child;Child Health;Child Rearing;Chromosomes;Clinical;Code;Conflict (Psychology);cost effective;critical period;Development;Discrimination;Disease;disease model;disorder risk;DNA;DNA Methylation;early childhood;early experience;Early Intervention;early life adversity;early life stress;epidemiology study;epigenetic aging;experience;Exposure to;Funding;genome integrity;Goals;Health;health disparity;Health Resources;Healthcare;Heritability;Home visitation;improved;Informal Social Control;innovation;Intervention;Investments;late life;Length;Life;Life Cycle Stages;Link;Longitudinal cohort study;Longitudinal Studies;Low income;maternal stress;Measures;Mediating;Mediator;mortality;Mother-Child Relations;Mothers;National Institute of Child Health and Human Development;novel;nutrition;obstetrical complication;Onset of illness;Outcome;Parents;Participant;Paternal Age;Pathway interactions;poor health outcome;Population;postnatal;postnatal period;Poverty;Predisposition;Pregnancy;Premature Mortality;prenatal;preservation;Prevalence;prevent;Prevention;preventive intervention;prospective;protein structure;psychosocial;Public Health;public health relevance;Quality of life;Race;Reporting;Research;Risk;risk mitigation;Role;Saliva;sex;Shapes;Stress;success;telomere;Time;Videotape;Visit

PROJECT_TITLE: “Early Life Experience and Childhood Telomere Biology: A Longitudinal Study of Developmental Context and Behavioral Mediators.

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Large outbreaks of enterovirus D68 (EV-D68) infections are becoming more frequent and are associated with paralytic disease (acute flaccid myelitis). We will use in vivo, ex vivo, and in vitro models to identify specific EV-D68 sequences and pathogenic mechanisms that lead to the development of paralytic disease. An increased knowledge of mechanisms that are involved in EV-D68 AFM will inform the development of broad-spectrum antivirals.

PI_NAMEs: TYLER, KENNETH L. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 5' Untranslated Regions;acute flaccid myelitis;Acyclovir;Age;age related;age-related disease;Anti-viral Agents;antiviral drug development;Apoptosis;Brain;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Central Nervous System Viral Diseases;Cerebrospinal Fluid;Cerebrum;Cessation of life;Child;Clinical;Communities;Dependence;Development;disability;Disease;Disease Outbreaks;emerging pathogen;emerging virus;Enterovirus;Enterovirus 68;Epidemic;epidemiology study;experience;Experimental Models;experimental study;Genetic;Genomics;Herpes encephalitis;Human;human disease;Human poliovirus;Immune response;Immunodeficient Mouse;improved;In Vitro;in vitro Model;in vivo;Incidence;Induced pluripotent stem cell derived human neuron;Induction of Apoptosis;Infection;Innate Immune Response;innovation;Interferons;Intramuscular Injections;juvenile animal;Knowledge;Link;member;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Motor Neurons;mouse model;Mus;Mutation;Nature;neonatal infection;neonatal mice;Nervous System Disorder;Neurons;neurovirulence;novel;Paralysed;Pathogenesis;pathogenic virus;Pathogenicity;Patients;Pattern;Peripheral;Pharmacologic Substance;Poliomyelitis;prevent;previous outbreak;Proteins;Recovery;Research Personnel;respiratory;Respiratory Disease;response;retrograde transport;Role;Sensory;Signal Transduction;Slice;Spinal Cord;Spinal cord injury;Testing;Therapeutic;Therapeutic Intervention;Time;United States;Viral;Viral Pathogenesis;Viral Structural Proteins;Virulence Factors;Virus;Virus Diseases

PROJECT_TITLE: Genomic and molecular determinants of EV-D68 neuroinvasive disease

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Obesity and Type 2 diabetes have reached epidemic proportions. We will investigate the molecular mechanisms involved in the inflammatory link between obesity and diabetes, focusing on the crucial protein kinase TBK1, and its role as a master regulator of metabolism.

PI_NAMEs: SALTIEL, ALAN R. (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;amlexanox;Attenuated;attenuation;Binding;Biogenesis;Body Weight decreased;Brown Fat;Caloric Restriction;Catecholamines;combat;Data;Development;Diabetes Mellitus;dieting;Disease;Effectiveness;Energy Metabolism;Enzymes;Epidemic;Event;Expenditure;Famines;Fasting;Fatty Liver;Feedback;FOXO1A gene;Gene Expression;Genetic Transcription;High Fat Diet;Homeostasis;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;insight;Insulin;Insulin Resistance;interest;Knock-in Mouse;Knockout Mice;Link;lipid biosynthesis;Lipids;liver inflammation;Longitudinal Studies;Mediating;Messenger RNA;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;Mitochondria;Molecular;mouse model;Mus;Mutant Strains Mice;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;Obese Mice;obese patients;Obesity;Obesity Epidemic;oxidation;Pathway interactions;Patients;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;preservation;programs;promoter;Protein Kinase;Regulation;Repression;restoration;Role;Scaffolding Protein;Starvation;TBK1 gene;Time;Transcriptional Regulation;Uncertainty

PROJECT_TITLE: Regulating energy expenditure in adipose tissue

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Neurosciences;Pediatric

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed project is aimed at testing a novel hypothesis that the learning deficit in DLD is rooted in an ineffective management of the interaction between explicit and implicit learning, caused by an impaired executive function of shifting. The project proposes that children with DLD demonstrate overreliance on explicit learning, and are failing to initiate a shift to implicit learning during complex learning, because of their impaired executive function of shifting. Children will perform two artificial grammar learning tasks that require the extraction of regularities from a complex structure. Behavioral and electrophysiological measures of learning outcomes, learning strategies, and implicit knowledge will be assessed in relation to the executive function of shifting, and compared between children with DLD and age and gender matched controls. The two learning tasks will differ in the extent to which the use of explicit learning is suppressed. The suppression of explicit learning will allow the evaluation of implicit learning without the interference of explicit learning, and without reliance on shifting. The study will subsequently determine whether the suppression of explicit learning improves learning of complex structures in children with DLD.

PI_NAMEs: ARBEL, YAEL  (contact)

PROJECT_TERMS: Adult;Affect;Age;Awareness;behavior measurement;Behavioral;Child;Clinical;clinically relevant;Cognitive;Communication impairment;Complex;Conscious;Data;design;Development;Disease;Educational process of instructing;effective intervention;Electrophysiology (science);Evaluation;Event-Related Potentials;Executive Dysfunction;executive function;Exhibits;explicit bias;Gender;Goals;hearing impairment;Human;Impairment;improved;innovation;Intellectual functioning disability;Intervention;Knowledge;Language;Language Development;Language Development Disorders;language impairment;Learning;Learning Difficulty;learning outcome;learning strategy;life-long learning;Linguistics;Measures;Memory;mental set;Methodology;Neurologic Deficit;neurophysiology;novel;operation;Pathologist;Pattern;peer;Pilot Projects;Reaction Time;Reporting;response;School-Age Population;Speech;Structure;Subconscious;success;syntax;Techniques;Testing;theories;Training;verbal

PROJECT_TITLE: Examining the impaired learning mechanism in children with developmental language disorder


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative The HIV-1 pandemic remains an ongoing health crisis, with drug resistance and the elimination of the rapidly- established latent reservoir continuing to thwart efforts to eradicate the infection. This research project focuses on virus-cell interactions to investigate the interplay between the HIV-1 replication machinery and cellular factors that assemble to form biomolecular condensates. Our innovative project also considers the influence that substance use disorder may have on HIV-1 replication, with the ultimate goal of finding ways to disrupt infection.

PI_NAMEs: PARENT, LESLIE J (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antiretroviral therapy;Binding;Biochemical;Biogenesis;Biological;Biology;biophysical properties;Biophysics;Cell Nucleus;Cells;Cessation of life;Clinic;combat;Complex;Coupling;Data;Disease;Dissociation;drug of abuse;Drug resistance;drug resistant virus;Drug Targeting;follow-up;gag Gene Products;Gene Expression;Genetic;Genetic Determinism;Genetic Transcription;Genome;genomic RNA;Goals;Health;Hela Cells;HIV;HIV-1;HIV/AIDS;immunodeficiency;In Vitro;in vitro Assay;Incidence;Infection;innovation;Integration Host Factors;Intervention;knock-down;Knowledge;Liquid substance;live cell imaging;Methods;Molecular;new therapeutic target;novel;Nuclear;Nuclear Export;pandemic disease;Pathway interactions;Persons;pharmacologic;Pharmacology;Phase;Phase Transition;Physical condensation;Play;Positive Transcriptional Elongation Factor B;Process;Production;Property;Proteins;Proteomics;Proviruses;Publishing;reactivation from latency;Regulation;Research Project Grants;Retrovirology;Ribonucleoproteins;RNA;RNA chemical synthesis;RNA Processing;Role;Scientist;Site;Structure;Substance Use Disorder;T-Cell Activation;T-Lymphocyte;Testing;therapeutic development;transcription factor;treatment strategy;Viral;viral RNA;Virion;Virus;Virus Latency;Virus Replication;Virus-Cell Membrane Interaction;Work

PROJECT_TITLE: Role of biomolecular condensates in regulating HIV-1 viral ribonucleoprotein complex formation in the setting of substance use disorder


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Nutrient handling in the gastrointestinal tract is a complex process that involves digestive enzymes and nutrient transport. Nutrients that are non-digestible by us are broken down by microbes normally residing in the GI tract, which contribute energy and other benefits to the host. The regulation of these events requires endocrine cells that reside in the intestine. This project seeks to uncover how endocrine cells in the large intestine regulate microbial nutrient digestion and host metabolism, which has important implications to our understanding of how obesity occurs.

PI_NAMEs: BURSTEIN, EZRA  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Address;Affect;age related;Antibiotic Therapy;autocrine;bacterial metabolism;blood glucose regulation;Body Weight;Calories;Carbon;Cell Differentiation process;cell fate specification;Cells;Chemicals;Colitis;Colon;colon microbiota;Colonic inflammation;Complex;density;Desire for food;Digestion;Distal;Distant;dysbiosis;Electrolytes;Endocrine;Endowment;Energy Metabolism;Enteroendocrine Cell;Enzymes;Epithelium;Event;Feces;Fermentation;Food;gastrointestinal epithelium;gastrointestinal function;Gastrointestinal Physiology;Gastrointestinal tract structure;Generations;Genes;Goals;gut microbiome;gut microbiota;High Fat Diet;Homeostasis;Hormonal;Hormones;Human;Hyperphagia;Hypothalamic structure;Immune response;Impairment;insight;Intestinal Content;Intestines;Investments;Laboratories;Large Intestine;Lipids;Liver;Location;Malabsorption Syndromes;Metabolic;Metabolic Control;metabolic phenotype;Metabolism;Microbe;microbial;microbiota composition;mouse model;Mus;Mutation;Neurosecretory Systems;novel;Nutrient;nutrient absorption;nutrient metabolism;nutrition;Obesity;Organ;Organism;Pancreas;paracrine;Phenotype;Play;postnatal;Predisposition;prevent;Process;Regulation;response;Role;sensor;Small Intestines;small molecule;Source;Spatial Distribution;Stimulus;Stomach;Testing;Time;Tissues;Volatile Fatty Acids;Water;Weight maintenance regimen;Wild Type Mouse;Work

PROJECT_TITLE: Role of colonic enteroendocrine cells in metabolic control

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Protein replacement therapy is a cornerstone in the treatment of genetic diseases with loss/reduction of function of a particular protein, by using recombinant proteins or recombinant engineered proteins. Nevertheless, these conventional replacement therapies have formidable limitations such as the requirement of burdensome frequent dosing. This project aims to advance a transformative long-acting mRNA replacement therapy for patients with severe genetic disorders such as hemophilia.

PI_NAMEs: SHI, JINJUN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Address;Adverse event;Antibodies;Apoptosis;Benchmarking;biomaterial compatibility;Blood;Blood Chemical Analysis;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Cholesterol;Clinical;Clinical Trials;Coagulation Process;COVID-19 vaccine;Dependovirus;Disease;disease model;Dose;Eligibility Determination;enzyme replacement therapy;Erythropoietin;F8 gene;Factor IX;Factor VIII;FDA approved;Formulation;Galactose;gene therapy;Generations;Genes;Genetic;Genetic Diseases;Half-Life;head-to-head comparison;Heart;Hematocrit procedure;Hematology;Hemophilia A;Hemophilia B;Hepatocyte;Human;improved;In Vitro;in vivo;Injections;interest;interpatient variability;Intravenous infusion procedures;Ligands;lipid nanoparticle;Lipids;loss of function;Lung;Measures;Mediating;Medical;Messenger RNA;Modeling;Monitor;mRNA delivery;mRNA Expression;mRNA Translation;Mus;nanoparticle;Organ;Other Genetics;Patients;Play;Population;Production;Protein Engineering;protein expression;protein function;Proteins;Recombinant Proteins;Recombinants;Replacement Therapy;research clinical testing;restoration;RNA vaccine;Safety;safety study;Secondary to;Stains;success;Surface;Technology;Testing;Therapeutic;Time;Toxic effect;Validation;Work

PROJECT_TITLE: A New Lipid Nanoparticle Technology Enabling Long-acting mRNA Therapy


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative The precise assembly and operation of the release apparatus for neurotransmitters is critical for normal brain function and is affected in brain disease. In this project, we study the mechanisms through which the secretory apparatus of synapses is assembled. Our results will provide detailed molecular insights into mechanisms of neuronal communication and how such communication fails in brain disorders.

PI_NAMEs: KAESER, PASCAL SIMON (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Ablation;Acute;Affect;Affinity;Binding;Binding Proteins;Brain;Brain Diseases;Cell Line;Cell membrane;Cells;Collection;Communication;Complex;Docking;Electron Microscopy;Electrophysiology (science);experimental study;flexibility;Fluorescence Recovery After Photobleaching;Freezing;Gene Family;Genes;Goals;Hippocampus;Image;Individual;insight;Knock-out;knockout gene;Light;Link;Liquid substance;Mediating;Membrane;Methodology;Microscopy;Modeling;Molecular;mouse genetics;mutant;Mutant Strains Mice;Nerve;Neurons;neurotransmitter release;Neurotransmitters;novel strategies;operation;Phase;Phosphatidylinositol 4,5-Diphosphate;Physical condensation;postsynaptic;predictive modeling;pressure;presynaptic;presynaptic neurons;Process;Property;protein complex;Protein Dynamics;Proteins;reconstitution;recruit;resilience;Role;scaffold;Scaffolding Protein;Site;Slice;stoichiometry;Structure;Surface;Synapses;Synaptic Receptors;Synaptic Vesicles;Tertiary Protein Structure;Testing;Transfection;Vesicle;Work;Zinc Fingers

PROJECT_TITLE: Dissecting the assembly of neurotransmitter release sites


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hearing loss is largely irreversible because in most cases it involves the loss of cochlear hair cells, which in mammals are for the most part not generated past embryogenesis. Deafness may occur due to death of IHCs or, more commonly, OHCs, and thus the regeneration of these specific hair cell types would be necessary to restore hearing. The conversion of IHCs into OHCs that we have discovered in Tbx2 mutants provides unique and novel means for elucidating how these two complementary mechanosensory cell types are generated, knowledge that will guide and assist future therapeutic attempts via regeneration.

PI_NAMEs: GARCIA-ANOVEROS, JAIME  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Ablation;Affect;Age;age related;ATAC-seq;Automobile Driving;Binding;Binding Sites;Brain;Cell Differentiation process;cell type;Cells;Cessation of life;Chromatin;Cleavage Under Targets and Release Using Nuclease;Cochlea;critical period;deafness;Development;Ectopic Expression;Embryo;Embryonic Development;Endowment;Enhancers;Epigenetic Process;epigenome;epigenomics;Event;Future;Gene Expression;Gene Modified;gene repression;Genes;Genetic Enhancer Element;Genome;Genomics;Hair Cells;Hearing;hearing impairment;hearing restoration;In Situ Hybridization;Inner Hair Cells;Knowledge;Life;Maintenance;Mammals;Maps;Modeling;Molecular;mutant;Natural regeneration;Neurons;Noise;novel;Outer Hair Cells;Pattern;Play;postnatal;presynaptic;prevent;promoter;receptor;Regulation;Regulatory Element;Role;Site;sound;sound frequency discrimination;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Toxin;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptome;transcriptomics;transdifferentiation;transmission process

PROJECT_TITLE: Transdifferentiation in the Cochlea


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative In 2012 President Obama signed the National Alzheimer's Plan Act with a primary objective to decrease racial disparities of Alzheimer's disease and related dementias (ADRD). While it is known that some ethnoracial groups have higher rates of dementia, reasons for these disparities are unknown. We propose to continue our unprecedented lifecourse cohort study of disparities in late life ADRD and cognitive outcomes, the Kaiser Healthy Aging and Diverse Life Experiences Study (KHANDLE). KHANDLE Cycle 1 enrolled 1712 diverse elderly individuals with the goal of delineating lifecourse drivers of disparities in rates of ADRD and cerebropathology. In KHANDLE Cycle 2 we will enroll an additional 500 participants and extend our study outcomes to incidence of ADRD, cognitive decline and changes in neuroimaging based biomarkers of neurodegeneration and vascular brain injury.

PI_NAMEs: GILSANZ, PAOLA ;GLYMOUR, MEDELLENA MARIA;MAYEDA, ELIZABETH ROSE;WHITMER, RACHEL A (contact)

PROGRAM_OFFICER_NAME: PERCY-LAURRY, ANTOINETTE LOIS

PROJECT_TERMS: Acceleration;Acculturation;Address;Adult;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Asian population;Behavioral;Biological Markers;Black Populations;Black race;Blood Vessels;Brain;Brain imaging;cardiovascular risk factor;Cerebrovascular Trauma;Cerebrum;checkup examination;Childhood;childhood adversity;Clinical;clinical phenotype;Clinical Protocols;Cognitive;Cognitive aging;cognitive change;cohort;Cohort Studies;Community Health;comorbidity;Consent;COVID-19 pandemic;Data;Data Collection;Data Linkages;Dementia;Development;Discrimination;Disparity;disparity reduction;early onset;Education;Elderly;Enrollment;Epidemiologic Methods;ethnic disparity;Ethnic Origin;Ethnic Population;ethnoracial;experience;Exposure to;Face;Family member;Female;Future;Goals;Health;health disparity;healthy aging;Heterogeneity;high risk;high school;human old age (65+);Image;Impaired cognition;Incidence;Individual;Infrastructure;interest;Investigation;late life;Latino;Latino Population;Life;Life Cycle Stages;Life Experience;Life Style;lifetime risk;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical;Medical Records;men;middle age;mild cognitive impairment;mortality;Mothers;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;Outcome;Outcome Study;Participant;Pathology;Phase;Population Heterogeneity;Positioning Attribute;Positron-Emission Tomography;predictive marker;Prevalence;programs;prospective;Psychometrics;psychosocial;Public Health;racial disparity;racial diversity;racial population;Recording of previous events;recruit;Reporting;Research;Risk;Risk Reduction;Role;Security;Sex Differences;Stress;Time;United States;vascular injury;Visit;Woman;β-amyloid burden

PROJECT_TITLE: Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Exposure to cues associated with drug use can trigger relapse in persons suffering from cocaine use disorder. The proposed research is in line with NIH's mission of reducing the burden of neuropsychiatric disease as it characterizes the involvement of a unique neuronal population, cholinergic interneurons, that may contribute to the persistence of high levels of cue-induced cocaine craving, in both male and female rats. By focusing on a novel target in relation to persistent drug craving, this work has the potential to identify novel therapeutic interventions for preventing relapse and thus prolonging abstinence.

PI_NAMEs: KAWA, ALEXANDER BORG (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abstinence;addiction;Advisory Committees;Affect;Affinity Chromatography;Behavior;biological adaptation to stress;career development;cell type;Choline O-Acetyltransferase;cholinergic;Cocaine;cocaine craving;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Committee Members;Corpus striatum structure;craving;Cues;designer receptors exclusively activated by designer drugs;Disease;Dopamine D2 Receptor;drug abstinence;Drug Addiction;drug craving;Drug usage;Enterobacteria phage P1 Cre recombinase;Exhibits;expectation;experience;experimental study;Exposure to;Female;Fiber;Genetic;Goals;Homeostasis;Human;Immunohistochemistry;Immunoprecipitation;in vivo;Incentives;Incubated;Individual;Interneurons;Learning;Ligands;Link;male;Measures;Mediating;Memory;Mentors;Messenger RNA;Methods;Mission;Modeling;Molecular;Monitor;motivated behavior;Motivation;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;Nucleus Accumbens;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Photometry;Play;Population;Procedures;prolonged abstinence;Proteins;Proxy;Quantitative Reverse Transcriptase PCR;Rat Transgene;Rattus;receptor expression;receptor function;Receptor Signaling;Regulation;Relapse;relapse prevention;Research;response;Ribosomes;Role;Saline;selective expression;Self Administration;skills;Testing;Time;tool;Training;Translating;Translations;United States National Institutes of Health;Viral;Virus;Withdrawal;Work

PROJECT_TITLE: Nucleus accumbens cholinergic interneurons and cue-induced cocaine craving

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Diabetes;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PHR: Project Narrative Cardio-metabolic diseases including diabetes, obesity, cardiovascular diseases and fatty liver disease affect a large fraction of the adult population of the US. The identification of preventable risk factors is therefore a priority. This project aims to determine whether women who experience greater exposures to environmental chemicals during pregnancy may be at greater risk for developing cardio-metabolic disease later in life.

PI_NAMEs: DABELEA, DANA  (contact);STARLING, ANNE

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Address;Adult;Affect;Air;Air Pollutants;ambient air pollution;Attention;Behavior;Behavioral;Birth;Body Composition;Body mass index;Body Weight;Breast Feeding;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;Chemical Exposure;Child;Child Health;Chronic Disease;cohort;Cohort Studies;Collaborations;Data;Data Collection;Diabetes Mellitus;diabetes risk;Diet;disorder risk;Enrollment;Environment;environmental chemical;environmental chemical exposure;Environmental Exposure;Environmental Impact;ethnic diversity;Evaluation;Event;experience;Exposure to;Fatty acid glycerol esters;fatty liver disease;Flame Retardants;follow-up;Funding;Gestational Diabetes;gestational weight gain;Glucose;Health;Hepatic;improved;Infant Health;Joints;Life;Life Cycle Stages;life span;Link;lipid metabolism;Longitudinal Studies;Magnetic Resonance Imaging;Maternal Health;maternal outcome;Measurement;Medical Records;Metabolic;Metal exposure;Metals;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute of Environmental Health Sciences;novel;Obesity;obesity risk;offspring;OGTT;Organophosphates;Outcome;Parabens;Participant;Persons;Phenols;phenotypic data;phthalates;Plethysmography;pollutant;Poly-fluoroalkyl substances;Population;post pregnancy;Postpartum Period;postpartum weight;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy hypertension;Pregnancy Outcome;Pregnant Women;prevent;Productivity;public health intervention;Records;recruit;Research;Research Personnel;residence;Risk;Risk Factors;risk mitigation;Role;Serum;Statistical Methods;Sturnus vulgaris;Time;Unhealthy Diet;urinary;Visit;Weight;Weight Gain;Woman;Women's cohort;Women's Group;Women's Health

PROJECT_TITLE: Environmental chemical exposures during pregnancy and women's cardio-metabolic health


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne emerging pathogen that causes severe and often fatal hemorrhagic fever in humans across a broad geographic range that includes more than 30 countries. CCHFV is of particular importance to public health as there are no licensed vaccines or treatments available for use in humans and because of the concern that it could be used as an agent of biological terrorism. The recombinant vaccine proposed here offers a potential medical countermeasure that can provide coverage across all six genetically distinct clades of CCHFV.

PI_NAMEs: GEISBERT, THOMAS WILLIAM (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Advanced Development;Africa;Animal Model;Animals;Applications Grants;Arboviruses;Attenuated;Biological Assay;Biological Products;Biological Sciences;Biology;Bioterrorism;bioweapon;Category A pathogen;Clinical Treatment;Cluster randomized trial;Containment;Country;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;cross immunity;Cyclic GMP;Dengue Virus;design;Disease;Disease Outbreaks;Dose;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Effectiveness;emerging pathogen;Generations;Genomic Segment;Geography;Glycoproteins;Goals;GTP-Binding Proteins;Guinea;Head;Health Personnel;high risk;HIV vaccine;HIV Vaccine Trials Network;Human;Immunization;immunogenic;immunogenicity;Knockout Mice;Laboratories;Lassa virus;Lead;lead candidate;Licensing;Life;Macaca fascicularis;manufacture;Marburgvirus;Medical;medical countermeasure;Modeling;Mus;National Institute of Allergy and Infectious Disease;National Security;Nature;neurovirulence;next generation;nonhuman primate;open label;Pathogenicity;Pharmaceutical Preparations;Phase;pre-clinical;preclinical development;prevent;Preventive vaccine;protective efficacy;prototype;Public Health;Recombinant Vaccines;Recombinants;Reporter;Research;research and development;Research Personnel;Surface;tick-borne;tick-borne virus;Treatment Protocols;United States Food and Drug Administration;Vaccination;vaccine candidate;vaccine delivery;vaccine development;vaccine immunogenicity;vaccine trial;Vaccines;vector;vector vaccine;Vesicular stomatitis Indiana virus;Viral Hemorrhagic Fevers;Virulence;Virus;Virus Diseases;World Health Organization

PROJECT_TITLE: Preclinical Development of a Crimean-Congo Hemorrhagic Fever Virus Vaccine


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Atherosclerosis;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Lung infections are a worldwide public health crisis. They are the leading cause of acute respiratory distress syndrome (ARDS) and sepsis, and improvement in patient outcome has been virtually stagnant for decades. The goal of this proposal is to reveal the biological features of the immune receptor LOX-1 in response to respiratory infection, possibly revealing novel targets for clinical intervention in patients with or at risk for pneumonia and ARDS.

PI_NAMEs: QUINTON, LEE  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Alveolar;alveolar homeostasis;Alveolar Macrophages;Alveolitis;Anti-Inflammatory Agents;Atherosclerosis;Autopsy;Biological;Biological Process;Biology;Cardiovascular Diseases;Cells;Cessation of life;Circulation;Clinical;Clinical Pathways;Data;disorder risk;Emigrations;Endothelium;Feedback;Flow Cytometry;Fortification;Gene Expression Profile;Genes;Goals;granulocyte;Hematopoietic;Homeostasis;Human;Immune;Immunity;Immunologic Receptors;immunopathology;improved;in vivo;Infection;Inflammation;Inflammatory;Injury;Interruption;Intervention;Learning;Lectin;Lectin Receptors;Leukocytes;Ligands;Lipids;Low Density Lipoprotein Receptor;Lower Respiratory Tract Infection;Lung;Lung infections;lung injury;Macrophage;Membrane Proteins;Messenger RNA;Morbidity - disease rate;mortality;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;neutrophil;Neutrophil Infiltration;novel;Outcome;oxidized low density lipoprotein;Patient-Focused Outcomes;Patients;Pilot Projects;Pneumonia;Population;PPAR gamma;programs;protective effect;protein expression;Proteins;Public Health;Pulmonary Inflammation;receptor;recruit;repository;resilience;Respiratory Tract Infections;response;Risk;Role;RXR;scavenger receptor;selective expression;Sepsis;sepsis induced ARDS;Shapes;Signal Transduction;Site;Source;Specimen;System;Testing;tissue injury;Tissues;Vascular Endothelium;vascular injury;Viral;virtual

PROJECT_TITLE: LOX-1 as a protective countermeasure in response to lung infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-H(03)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE A lack of diversity among investigators is a strong impediment to resolving national and global challenges related to substance misuse. Certain early career investigators face multidimensional historical and social factors that hinder access to adequate mentorship, quality instruction, focused faculty attention, and the financial support necessary to become independent substance misuse and addition scientist. The proposed program, the Scientific Training in Addiction Research Techniques (START), is a trans-disciplinary drug abuse research education program for early career investigators dedicated to enhancing diversity in the next generation of substance misuse and addiction scientists.

PI_NAMEs: GARAVAN, HUGH P.;JOHNSON, MICAH  (contact);POTTER, ALEXANDRA S

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Academia;Achievement;addiction;Adolescence;Adolescent;Affect;Age;Attention;Award;Brain;Caliber;career;Child Health;Clinical;cognitive development;cohort;Collection;Communities;Data;data access;Data Analyses;Data Collection;data dissemination;Data Set;data structure;Dedications;Development;Dimensions;Disadvantaged;Disparity;diversity and inclusion;Drug abuse;drug misuse;education research;Elements;Employment;Enrollment;Environment;Evaluation;experience;Face;Faculty;Financial Support;Funding;Funding Opportunities;Future;Generations;Gifts;Goals;Grant;improved;Instruction;Life;Longitudinal Studies;matriculation;meetings;member;Mentors;Mentorship;Methods;minority communities;minority scientist;Monitor;National Institute of Drug Abuse;neighborhood disadvantage;next generation;Ontology;open data;Participant;pedagogy;peer;Persons;Postdoctoral Fellow;pre-doctoral;Professional Practice;professor;Program Evaluation;programs;Publications;Publishing;Qualifying;recruit;Research;research data dissemination;Research Design;Research Personnel;Research Project Grants;Research Technics;Resources;role model;Scientist;senior faculty;skills;social;social factors;Special Population;Students;Substance Addiction;substance misuse;substance use;Talents;Time;Time Management;Training;Training Programs;Training Technics;trend;undergraduate student;Underrepresented Minority;United States;Writing

PROJECT_TITLE: Scientific Training in Addiction Research Techniques (START) for gifted future investigators from historically underrepresented and underserved backgrounds.


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Hearing Loss;Human Genome;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This proposal explores epigenetic regulation of neurosensory cell development in the mouse inner ear. In humans, pathogenic variants in the chromatin remodeler gene CHD7 cause CHARGE syndrome, a congenital disorder affecting vision, hearing, cognition, and development of brain, craniofacial, skeletal, renal, and cardiac structures. Our aims assess roles for CHD7 in inner ear neurosensory cell development, to help establish a basis for the design of pharmacologic or gene-based therapies to treat hearing and vestibular disorders.

PI_NAMEs: KWAN, KELVIN Y.;MARTIN, DONNA M. (contact)

PROJECT_TERMS: 3' Untranslated Regions;Acetylation;Adult;Affect;American;ATAC-seq;Binding;Brain;Cardiac;cell type;Cells;CHARGE syndrome;CHD7 gene;Child;Choanal Atresia;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Cochlea;cochlear development;Cognition;Coloboma;Conductive hearing loss;Congenital Disorders;craniofacial;CRISPR interference;Delayed Puberty;design;Development;Diagnosis;Disease;DNA;DNA-Binding Proteins;Ear;ear development;Economic Burden;Enhancers;environmental change;Epigenetic Process;epigenetic regulation;Epithelium;equilibration disorder;Exhibits;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;Ganglia;Gene Expression Regulation;gene therapy;Genes;Genetic Transcription;Genitalia;Growth and Development function;Hair Cells;Hearing;hearing impairment;Hearing problem;heart defect;Heritability;Histones;Human;In Situ Hybridization;In Vitro;in vivo;inner ear development;Kidney;Knowledge;Labyrinth;Mesenchyme;Methylation;Microscopy;Mixed Conductive-Sensorineural Hearing Loss;Modification;mouse genetics;Mus;Mutation;Neuronal Differentiation;Neurons;neurosensory;Nucleic Acid Regulatory Sequences;Nucleosomes;Optics;Otic Vesicle;Pathogenicity;Pathway interactions;Patients;pharmacologic;Positioning Attribute;progenitor;promoter;Proteins;Quality of life;reconstruction;recruit;regenerative;Regulatory Element;Role;Sensorineural Hearing Loss;Sensory;Sensory Hair;single cell sequencing;single molecule;single-cell RNA sequencing;skeletal;socioeconomics;SOX11 gene;Specific qualifier value;Stem Cell Development;stem cells;Structure;superresolution microscopy;Testing;Tissues;Transcript;Untranslated RNA;Variant;Vestibular Diseases;Vestibular epithelia;Vision

PROJECT_TITLE: Epigenetics of inner ear neurosensory cell development

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Machine learning tools can help biomedical researchers to understand their data or to make predictions. Acquiring labeled examples from biomedical experts is a significant limitation in developing machine learning tools. These tools also often fail to generalize beyond the datasets used for tool development. Improving the efficiency of data labeling and generalization would increase the impact of these tools in biomedical research.

PI_NAMEs: COOPER, LEE  (contact);ENQUOBAHRIE, ANDINET ASMAMAW

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Active Learning;Address;algorithm training;Algorithms;base;Bayesian neural network;Biological;Biomedical Research;Classification;Clinical Informatics;Clinical Research;Clinical Trials;cloud platform;Code;cohort;Collaborations;Communities;Computer software;Computer Systems;computing resources;Data;Data Scientist;Data Set;Databases;Dedications;deep learning;deep learning algorithm;digital pathology;Environment;experience;Face;feature extraction;Fetal health;Funding;Growth;hands-on learning;High Performance Computing;Histologic;Human;human-in-the-loop;Image;improved;Institution;K-Series Research Career Programs;Knowledge;Label;large datasets;Learning;learning strategy;Machine Learning;machine learning algorithm;machine learning model;Malignant Breast Neoplasm;Maternal Health;Measurement;Methodology;Methods;multidimensional data;Natural Language Processing;novel strategies;open source;Pathologist;Pathology;pathology imaging;Pattern;Performance;Perinatal;Placenta;Process;public health relevance;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Resources;Sampling;Science;simulation;Site;software development;Software Framework;Software Tools;Source;Structure;Tissue imaging;tool;tool development;Training;United States National Library of Medicine;unsupervised learning;whole slide imaging;Work

PROJECT_TITLE: Guiding humans to create better labeled datasets for machine learning in biomedical research

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Activity;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: PROJECT NARRATIVE Women interpersonal violence (IV) survivors are at risk for experiencing stigma which can compound IV-related distress and “downstream” adverse health outcomes, and intersectionalities of vulnerable identities amplify health risk. The proposed community-engaged integrated trauma-informed yoga and adapted mindful self- compassion (I-YMSC) intervention offers a complementary and integrative approach (CIA) for reducing distress as a mechanism for improving psychological, behavioral, and physical health in ethno-racially diverse women. Short-term, this research will contribute to our understanding of the feasibility and acceptability of a novel, multicomponent CIA to reduce distress among diverse IV survivors; long-term, this research has potential to increase our knowledge of approaches to promote health equity in other marginalized groups.

PI_NAMEs: BRAUN, TOSCA  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;African American;African American Women;behavior test;behavioral health;Black race;Breathing;Chronic Disease;Clinical;Clinical Trials;Communities;community engaged approach;community engaged research;community setting;comparison intervention;Complementary Medicine;Cultural Sensitivity;Data;design;Development;diagnostic strategy;Disease;Distress;Educational process of instructing;efficacy trial;Ensure;Ethnic Origin;ethnoracial;experience;Focus Groups;Fostering;Fright;Funding;Future;Grant;hands-on learning;Health;Health education;health equity;health equity promotion;Health equity research;health inequalities;Health Promotion;Hispanic;improved;innovation;instructor;internalized stigma;Interpersonal Violence;intersectionality;Intervention;intervention effect;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;Latina;Latino;Latinx;Learning;Manuals;marginalized population;Meditation;Mental disorders;Mental Health;Mentors;Methods;Mind-Body Method;mind/body;mindfulness;mindfulness intervention;Minority Groups;National Center for Complementary and Integrative Health;Not Hispanic or Latino;novel;Outcome;Participant;Phase;physical conditioning;Physiological;pilot trial;Population;Posture;prevent;primary outcome;Program Evaluation;programs;Public Health;Race;racial diversity;Randomized;Regulation;Relaxation;Reporting;Research;Research Personnel;resilience;Resources;response;restoration;revictimization;Risk;Risk Behaviors;Risk Reduction Behavior;Safety;Scientist;secondary outcome;self-compassion;Series;Shame;skills;social stigma;Stigmatization;stress disorder;Subgroup;Survivors;Target Populations;teacher;Teacher Professional Development;Therapeutic Effect;Training;Training Programs;Trauma;Trust;United States National Institutes of Health;Variant;Violence;Vulnerable Populations;Weight;White Women;Woman;Work;Yoga

PROJECT_TITLE: Integrative Yoga and Mindful Self-Compassion to Reduce Distress in Women Survivors of Interpersonal Violence


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse;Telehealth

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: PROJECT NARRATIVE  People with a history of Opioid Use Disorder and criminal justice involvement are more likely to experience loneliness following release from jail/prison leading to negative outcomes such as treatment dropout and increased substance use. Providing peer recovery support, particularly through a highly accessible, digital health platform, is a potential way to decrease loneliness in this population. The current study seeks to test whether a mobile peer recovery support app, delivered to individuals with a recent history of taking medication for opioid use disorder while in jail/prison, will improve outcomes for this vulnerable population.

PI_NAMEs: LANGDON, KIRSTEN JOHNSON (contact);RAMSEY, SUSAN E

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adult;Ambulatory Care;Back;Cellular Phone;Communities;community reentry;COVID-19;Criminal Justice;Death Rate;Dedications;digital health;Dropout;Education;effectiveness/implementation study;Ethics;evidence base;Evidence based treatment;experience;Face;Facebook;Feeling;follow up assessment;formative assessment;future implementation;General Population;Geography;Goals;Health;high risk;HIV;Hybrids;illicit opioid;implementation barriers;implementation evaluation;implementation facilitators;Imprisonment;improved;improved outcome;Income;Individual;Interview;Jail;Justice;Knowledge;Loneliness;Manuals;medication for opioid use disorder;mobile application;Natural Language Processing;novel;opioid mortality;opioid use;opioid use disorder;Outcome;Outpatients;overdose death;Participant;peer;peer recovery;peer support;Persons;Pharmaceutical Preparations;Population;primary outcome;Prisons;programs;prospective;Public Health;Randomized, Controlled Trials;Recording of previous events;Recovery;Recovery Support;recruit;Research;Resources;Risk;Risk Factors;secondary outcome;Secure;Security;Self Efficacy;Self-Injurious Behavior;social;social group;social stigma;Social support;standard of care;Structure;substance use;Target Populations;Testing;Text;Time;transmission process;treatment as usual;uptake;violent crime;Vulnerable Populations;Work

PROJECT_TITLE: Improving social connectedness through digital health to enhance recovery from OUD among the justice involved population.


NIH_SPENDING_CATS: Genetics

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The differentiation of cells into functionally distinct types enables animals to build multicellular bodies and allows their closest-living relatives, choanoflagellates, to take advantage of different environments. Based on our working model that choanoflagellates and animals evolved cell differentiation programs from a common, ancestral genetic toolkit, this proposal advances molecular genetic tools in choanoflagellates to investigate the mechanisms that govern cellular differentiation in these aquatic microeukaryotes. This work will provide novel functional data to highlight the conservation or divergence or regulatory mechanisms in choanoflagellates and animals, thereby illuminating the core functions of genes that were foundational for the origin of animals and that remain integral for human biology.

PI_NAMEs: BOOTH, DAVID SCOTT (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;Biological Models;Biology;Cell Differentiation process;cell type;Characteristics;Cues;Cytology;Data;Development;Environment;Eukaryota;Evolution;functional genomics;Gene Delivery;gene function;Genes;Genetic;genome editing;genome wide screen;Germ Lines;Homologous Gene;Human Biology;Methods;Mission;Modeling;Molecular;Molecular Genetics;novel;Pathway interactions;Phenotype;pluripotency;Postdoctoral Fellow;programs;Regulatory Pathway;Research;RNA-Binding Proteins;Shapes;Surveys;tool;Work

PROJECT_TITLE: The ancestry of animal cell differentiation and pluripotency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Drug therapy is required to treat trypanosomatid parasite infections, yet existing drugs suffer from challenging treatment regimens, emerging drug resistance, and significant gaps in our understanding of their mechanisms of action and trypanocidal targets. The proposed research will use a state-of-the-art genetic screening tool to identify genes whose expression promotes resistance against the clinically relevant anti-trypanosomatid drugs currently in use. The phenotypes imparted by multi-resistance genes will then be evaluated to identify pathways that result in drug resistance and, conversely, cell death, the outcomes of which will be transformative for future drug development in trypanosomatid parasites.

PI_NAMEs: HOVEL-MINER, GALADRIEL ASTRA (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: African;African Trypanosomiasis;Antiparasitic Agents;Benznidazole;bioinformatics pipeline;Biological Process;Biosensor;Blood Circulation;Cell Cycle;Cell Death;cell killing;Cell Line;Cell Survival;Cells;Clinical;clinically relevant;Complex;conditional knockout;Cytology;Cytosol;cytotoxic;cytotoxicity;Data;Defect;Development;Disease;DNA biosynthesis;DNA Damage;Drug Design;drug development;drug mechanism;Drug resistance;Drug resistance pathway;Drug Targeting;Eflornithine;Encephalopathies;Ensure;fexinidazole;Future;gain of function;Gene Expression;Genes;Genetic;Genetic Screening;Genome Stability;Human;improved;Individual;Infection;insight;Intravenous;knock-down;Knowledge;Legal patent;Leishmania;Libraries;Link;Literature;Measurable;Measures;Melarsoprol;Membrane Potentials;Metabolism;Methods;Mitochondria;Mitochondrial Proteins;Molecular Target;Multi-Drug Resistance;new therapeutic target;next generation;Nifurtimox;novel;novel therapeutics;Oral;Outcome;overexpression;Oxidation-Reduction;Parasites;Parasitic infection;Pathway interactions;Pentamidine;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Poverty;Process;Proteins;Publishing;Quality of life;Research;Resistance;resistance gene;resistance mechanism;Resources;RNA Interference;screening;Screening procedure;Spliced Leader RNA;Stress;stress management;Structure;success;Suramin;Survivors;Testing;Therapeutic;therapeutic development;Time;tool;Toxic effect;Treatment Protocols;Trypanocidal Agents;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Validation

PROJECT_TITLE: Dissecting multidrug resistance pathways in Trypanosomatids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-F(83)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Diabetes;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative  Clostridium perfringens requires branched chain amino acids (BCAAs) for growth and we have shown that contact of this bacterium with a differentiated muscle cell line upregulates expression of the C. perfringens gene encoding the BCAA transporter BrnQ2, so we will use BCAA transporter or toxin null mutants to test if a BCAA transporter(s) is important for C. perfringens growth using BCAAs in blood or toxin-damaged muscle cells. Furthermore, diabetics have elevated blood BCAA levels, so we will use BCAA transporter mutants in normal and diabetic mice to test whether BCAA transporter(s) is/are important contributor(s) to the association of C. perfringens-mediated gas gangrene with diabetics.

PI_NAMEs: LI, JIHONG ;MC CLANE, BRUCE A (contact);UZAL, FRANCISCO A

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: alpha Toxin;Amino Acid Transporter;Amino Acids;Anaerobic Bacteria;Bacteria;bacteria classification;Biological Assay;Blood;Branched-Chain Amino Acids;Cell Line;Cells;Clinical Research;Clostridium perfringens;Clostridium perfringens theta-toxin;Coculture Techniques;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Enteritis;Enterotoxemia;Environment;Family;fascinate;Food Poisoning;Gas Gangrene;Gene Expression;Genes;Growth;Human;improved;In Vitro;in vivo;Individual;Infection;inhibitor;Insulin-Dependent Diabetes Mellitus;Integration Host Factors;Lead;limb amputation;lysin;Mediating;Modeling;mortality;mouse model;Mus;Muscle;Muscle Cells;mutant;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;pathogen;Pathology;Predisposition;Production;Protein Biosynthesis;Risk Factors;Role;Soft Tissue Infections;Testing;Time;Toxin;Up-Regulation;uptake;Virulence;wound;Wound Infection

PROJECT_TITLE: Evaluating the role of branched chain amino acid transporters in Clostridium perfringens-induced gas gangrene in diabetic and normal mouse models

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Lung;Microbiome;Nutrition;Obesity

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE The research plan is designed to test the beneficial metabolic and anti-inflammatory actions of an endogenously present class of modified fats, termed nitro-fatty acids. This project provides a novel precision pharmacology therapy, oral CXA-10, for the treatment of obese asthma, a disease that responds poorly to standard asthma medications and increases airway hyperreactivity. The study will leverage both clinical variables (lung function, asthma control questionnaire and bronchial hyperreactivity) as well as the use of gut, lung, nasal, plasma and urine samples as a translational research tool to better understand obesity-mediated changes in relation to how CXA-10 effects changes in gene expression and how –omics profiles are modified by CXA-10.

PI_NAMEs: GELHAUS, STACY LYNN;HOLGUIN, FERNANDO  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acids;adipokines;Adult;Airway Disease;airway hyperresponsiveness;allergic airway disease;Anti-Inflammatory Agents;Asthma;asthmatic;asthmatic patient;Basic Science;Biochemical;Biological;Biological Markers;Blinded;Body mass index;bronchial epithelium;Bronchial Hyperreactivity;Bronchoalveolar Lavage;Bronchodilator Agents;Cells;Chronic;Clinical;clinical phenotype;Clinical Research;Cross-Over Studies;Crossover Design;cytokine;Data;design;Disease;drug candidate;Drug Kinetics;dysbiosis;Enzymes;evaluation/testing;Fatty acid glycerol esters;Fatty Acids;Feces;Functional disorder;Gene Expression;Gene Expression Profiling;Generations;Genome;gut-lung axis;Homologous Gene;Human;Immune response;Impact evaluation;Impairment;improved;Incidence;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Institutional Review Boards;insulin sensitivity;lipid mediator;Lipids;Lung;Mediating;Mediator;Metabolic;metabolic profile;Metabolic syndrome;Metabolism;metabolomics;metatranscriptomics;methacholine;microbial;microbiome;microbiota;mouse model;Nasal Epithelium;nitration;nitroalkene;Nitrogen Dioxide;Nitrogen Oxides;Nose;novel;novel drug class;obese person;Obesity;obesity treatment;obesity-associated asthma;Oral;Oral Administration;Oxidation-Reduction;Oxygen;Pathogenicity;Patients;Pharmaceutical Preparations;Pharmacology;phase 2 designs;phase 2 testing;Phase II Clinical Trials;Phenotype;Placebo Control;Plasma;Population;Post-Translational Protein Processing;pre-clinical;primary outcome;Publishing;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Questionnaires;Reaction;receptor;Research;Research Design;Resistance;Resources;response;Risk;Rodent;Safety;Sampling;secondary outcome;Signal Induction;Signal Transduction;Study Subject;Symptoms;Testing;Therapeutic Effect;tool;Toxicology;transcription factor;transcriptome sequencing;Translational Research;Unsaturated Fatty Acids;Urine;volunteer;whole genome;Work

PROJECT_TITLE: LIMA: Lipid anti-Inflammatory Mediators in Asthma to reduce airway hyperresponsiveness in obese asthmatics

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(OA)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative The true benefit of biomedical research to public health depends upon swift and efficient translation of scientific discoveries into the healthcare domain. This translation is accomplished first and foremost by the cadre of “bilingual” clinician-scientists who are at home in both the world of science and the world of clinical medicine. Our program aims precisely to nurture the development of such clinician-scientists in the field of otolaryngology – head and neck surgery.

PI_NAMEs: JUNG, DAVID H (contact);SIMONYAN, KRISTINA

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Otolaryngology;Research Training

PROJECT_TITLE: Research Training in Otolaryngology


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: PISCATAWAY

ORG_DEPT: CHEMISTRY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Our proposed studies are relevant to public health, as developing an injectable, biocompatible, and biodegradable method to form therapeutic 3D spheroids to promote stem cell therapy will facilitate CNS repair and modulate neuroinhibitory microenvironments after CNS injury. Therefore, the proposed research is relevant to the part of NIH’s mission that relates to treating human illness and disability by investigating how innovative technology can safely translate to clinics.

PI_NAMEs: LEE, KIBUM  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Axon;axon growth;axon regeneration;axonal sprouting;Biocompatible Materials;biodegradable scaffold;Biological Process;biomaterial compatibility;cell assembly;Cell Differentiation process;Cell Therapy;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Characteristics;Cicatrix;Clinic;Clinical;clinical application;Complex;controlled release;Cues;Data;Development;Differentiation and Growth;differentiation in vitro;disability;Disease;Drug Delivery Systems;effective therapy;Environment;Extracellular Matrix;Functional disorder;Generations;Gliosis;Goals;Growth;Human;Hybrids;Impairment;Implant;implantation;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;inhibitor;Injectable;Injury;innovation;innovative technologies;Investigation;Laminin;Medicine;Methods;Microglia;Mission;Modeling;multidisciplinary;nano;nanomaterials;Nanotechnology;Natural regeneration;Nerve Regeneration;nerve stem cell;Nervous System Disorder;neural;neural circuit;Neurites;neurogenesis;Neurologic Deficit;Neuronal Differentiation;neuronal growth;Neuronal Plasticity;neuronal survival;Neurons;Neurosciences;Neurosphere;new technology;next generation;notch protein;novel;Organoids;patient - derived stem cells;Patients;permissiveness;Population;Proliferating;Property;Public Health;Recovery of Function;regeneration potential;repaired;Research;scaffold;Signal Transduction;Site;spatiotemporal;spheroids;Spinal cord injury;stem cell biology;stem cell differentiation;stem cell fate;stem cell growth;stem cell survival;stem cell therapy;Stem cell transplant;stem cells;success;Survival Rate;synergism;System;Techniques;technology platform;Therapeutic;Therapeutic Effect;Therapeutic Intervention;three dimensional cell culture;Tissues;tool;Translating;Treatment outcome;tumor-immune system interactions;United States National Institutes of Health

PROJECT_TITLE: Injectable Hybrid SMART spheroids to enhance stem cell therapy for CNS injuries

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE: Opioid overdose-related deaths have surged worldwide in recent years, largely due to a lack of effective interventions for the sustained cessation of opioid use. Experiencing stressful events is an important risk factor for the development of opioid use disorder (OUD) and a common trigger for relapse, but the neural mechanisms that mediate these effects are incompletely understood. This proposal aims to provide foundational knowledge for OUD prevention and treatment development by (1) determining how stress alters heroin intake and relapse and by (2) systematically examining stress-induced neuroadaptations in a stress- and opioid-responsive population of ventral pallidal glutamate neurons.

PI_NAMEs: MILLER, CARLEY N (contact)

PROJECT_TERMS: Acute;acute stress;Address;Adult;Affect;Automobile Driving;Behavior;Behavior Disorders;Behavioral;behavioral response;Binding;biological adaptation to stress;Brain region;Catheters;Cells;Cessation of life;Clinical;Clinical Data;clinically relevant;comparative;Cues;Data;Development;Disease;disorder prevention;drug relapse;drug seeking behavior;Drug usage;effective intervention;Electrophysiology (science);Evaluation;Event;experience;experimental study;Exposure to;Female;Globus Pallidus;Glutamates;Goals;Growth;Heroin;heroin use;Image;Implant;in vivo;induced pluripotent stem cell;insight;Intervention;Intravenous;Investigation;Knowledge;Label;Life;Literature;male;Mediating;Mediator;Membrane;Modeling;Monitor;Motivation;mu opioid receptors;Mus;nerve supply;neuroadaptation;neurobiological mechanism;neuromechanism;Neurons;neuropathology;Opioid;Opioid agonist;opioid overdose;opioid use;opioid use disorder;Outcome;patch clamp;Pathology;Patients;Pharmaceutical Preparations;Physicians;Population;Positioning Attribute;postsynaptic;pre-clinical;preclinical study;Predisposition;Property;psychostimulant;Public Health;Receptor Activation;Relapse;Reporter;Reporting;Research;response;restraint stress;reward processing;Rewards;Risk Factors;Rodent Model;Scientist;Self Administration;sex;sexual dimorphism;skills;Slice;Stress;stress reactivity;stress reduction;Stressful Event;Substance Use Disorder;Synapses;synaptic function;Synaptic Transmission;System;therapeutically effective;therapy development;Training;Transgenic Organisms;Work

PROJECT_TITLE: Impact of stress on heroin seeking and ventral pallidal synapse function


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on discovery of novel signaling pathways that drive castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NIH's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LIU, XIAOQI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: abiraterone;Affect;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;Apoptosis;Automobile Driving;Binding;Biochemical;Biological Markers;Breeding;Cancer Patient;cancer therapy;Castration;Catalytic Domain;Cell Nucleus;Cells;Clinic;Clinical Research;Clinical Trials;Complex;Creativeness;Cytokine-Inducible Kinase;Cytoplasmic Receptors;Data;design;Development;diagnostic biomarker;Disease;Disease Progression;Drug resistance;effective therapy;Enhancers;enzalutamide;Epigenetic Process;Event;Fostering;gene repression;genetic approach;Genetic Transcription;Genetically Engineered Mouse;Goals;Health;Homologous Gene;improved;inhibitor;innovation;Investigation;Knock-out;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Methodology;Methylation;Mission;Mitotic;mouse model;Mus;mutant;Neuroendocrine Prostate Cancer;novel;novel marker;novel strategies;Oncogenic;Operative Surgical Procedures;Outcome;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;pharmacologic;Phosphorylation;PLK1 gene;Polycomb;programs;Prostate;prostate cancer cell;prostate cancer model;prostate cancer progression;PTEN gene;Public Health;Receptor Signaling;Research;Resistance;Resources;Role;Signal Pathway;Signal Transduction;Specimen;success;System;Testing;Therapeutic;therapeutic target;Transcriptional Activation;tumor;United States National Institutes of Health;Withdrawal;Work;Xenograft Model

PROJECT_TITLE: Overcoming Drug Resistance of Castration-Resistant Prostate Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_CITY: Los Alamos

ORG_NAME: TRIAD NATIONAL SECURITY, LLC

ORG_STATE: NM

PHR: Narrative The HIV-1 pandemic has been a major challenge in global public health for decades, and we do not have a medically scalable cure for it. Our work will help to find a cure by providing a quantitative framework to identify the determinants of viral remission after ART as well as a tool for estimating the efficacy and predicting the outcome of intervention strategies aiming to cure HIV.

PI_NAMEs: KE, RUIAN  (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acceleration;acute infection;Address;Affinity;Aftercare;Agonist;Antibodies;antiretroviral therapy;Binding;Biological;Biological Markers;Bispecific Antibodies;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;Clinical;Clinical Data;Clinical Trials;Combined Modality Therapy;Complex;Coupled;Data;Data Set;design;detection limit;Development;Disease remission;effective intervention;effective therapy;Effectiveness;Effector Cell;Exhibits;experimental study;Favorable Clinical Outcome;Foundations;Future;Grant;HIV;HIV-1;Immune;Immune response;Immune system;Immunologic Markers;Immunotherapeutic agent;In Vitro;in vivo;Individual;Integration Host Factors;Interruption;Intervention;Knowledge;latent HIV reservoir;Macaca;Macaca mulatta;mathematical model;Measurement;Measures;Medical;Modeling;neutralizing antibody;next generation;Outcome;outcome prediction;pandemic disease;Parameter Estimation;patient population;Patients;Prediction of Response to Therapy;Public Health;rational design;Research;response;Role;System;Testing;therapeutic development;Therapeutic Intervention;therapeutic vaccine;therapeutically effective;TLR7 gene;tool;Treatment outcome;treatment strategy;Viral;Viral Load result;viral rebound;Withholding Treatment;Work

PROJECT_TITLE: Modeling the HIV latent reservoir, latency reversal and immunotherapeutics for HIV cure

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE This application will employ high-throughput primary screens, medicinal chemistry, and biological hit validation assays to discover novel small-molecule inhibitors of the synaptic Rac-guanosine nucleotide exchange factor (GEF) kalirin. Such molecules could be developed into probes to study GEF function, synaptic plasticity, and the neurobiological bases of mental illness.

PI_NAMEs: LUAN, CHI-HAO ;PENZES, PETER  (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Acute;assay development;Autopsy;Award;base;Behavior;Binding;Biological;Biological Assay;Biological Process;Biology;Brain;cell type;Cerebral cortex;Chemicals;Collaborations;Crystallography;Dendritic Spines;Development;Disease;Excitatory Synapse;Family;Fluorescence;Functional disorder;Funding;Genetic;Genetic Diseases;Goals;Guanine Nucleotide Exchange Factors;Guanosine;Guanosine Triphosphate Phosphohydrolases;high throughput screening;Hippocampus;Immunomodulators;inhibitor;knock-down;Knock-out;Knowledge;Learning;Libraries;Mediating;member;Memory;Mental disorders;Molecular;Monomeric GTP-Binding Proteins;Neurobiology;neuronal circuitry;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel;Nucleotides;Pathogenesis;Pathology;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphotransferases;Play;postsynaptic;Process;Property;Proteins;Rattus;receptor;Recombinants;Regulation;Research;Role;screening;Signal Transduction;Site;small molecule;small molecule inhibitor;Specificity;Synapses;Synaptic plasticity;Testing;Therapeutic Intervention;Tissues;tool;Toxic effect;Translating;Triage;United States National Institutes of Health;Validation;Vertebral column

PROJECT_TITLE: Targeting Postsynaptic Small G-protein Regulators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Physical Activity;Prevention;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: NARRATIVE Individuals with physical disabilities have a right to full participation and inclusion in their communities – a right upheld by national and international laws and regulations. This basic right is not currently experienced, particularly within the domain of parasport and, more recently, the rapidly growing sector of active eSports. The proposed research will seek to explore and understand the experiences of individuals with physical disabilities in active eSports, with the goal of creating a knowledge base that can be used by future researchers to promote full participation in the active eSport community.

PI_NAMEs: SHIRAZIPOUR, CELINA HOVE (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TITLE: Full participation of people with physical disabilities in active eSports

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Neurodegenerative diseases and trauma to the CNS are major public health issues that afflict more than 50 million Americans yearly. This research program will lay the foundation for broad based and preventative therapies that will reduce the physical, emotional and financial impacts of these diseases on the public.

PI_NAMEs: GRILL, BROCK  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;American;Autophagocytosis;Autophagosome;Axon;axonal degeneration;Binding;Binding Proteins;Biochemical;Biochemistry;Biology;Caenorhabditis elegans;candidate identification;CDK5 gene;Cells;Code;Complex;CRISPR/Cas technology;Darkness;design;Development;Disease;Emotional;Engineering;Event;experimental study;Foundations;Funding;Genetic;genetic approach;genetic testing;Goals;Growth;Health system;Human;in vivo;inhibition of autophagy;inhibitor;insight;Integrins;interest;knock-down;Knowledge;Ligase;Link;loss of function;Mass Spectrum Analysis;Mediating;member;Molecular;multicatalytic endopeptidase complex;mutant;Nature;Nematoda;Nervous System;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuron development;Neurons;novel;novel therapeutics;Organism;Orthologous Gene;Outcome;Phosphorylation;Phosphorylation Site;Phosphotransferases;Play;Preventive therapy;Process;programs;Protein Family;Proteins;Proteomics;Public Health;Receptor Signaling;Research;resilience;Role;Sampling;Signal Transduction;Signaling Protein;SKP Cullin F-Box Protein Ligases;Structure;Synapses;Synaptic plasticity;synaptogenesis;System;Technology;Testing;Trauma;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Mechanisms of synapse formation and axon termination in C. elegans


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE Correlations in neural dynamics across the brains of interacting individuals are an emergent and highly conserved property of social interactions, but the functional relevance of these correlations remains enigmatic. In this proposal we will use a comparative multi-species approach, combining state-of-the-art wireless technological advances and cellular/subcellular resolution imaging with pioneering molecular-genetic tools to decipher the biological mechanisms that enable neural synchrony and unequivocally define its function. By moving beyond a correlative understanding of this intriguing emergent neural property, we will determine its role in successful social interaction and attachment, a finding with transformative implications for the manipulation of these dynamics in a therapeutic context.

PI_NAMEs: DONALDSON, ZOE REBECCA;KOZOROVITSKIY, YEVGENIA  (contact);ROGERS, JOHN

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony


NIH_SPENDING_CATS: Hematology;Orphan Drug;Pain Research;Pediatric;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: There is an unmet medical need to develop new treatment approaches for patients with genetic disorders, and intrauterine transplantation (IUTX) of hematopoietic stem cells is one of the few therapeutic approaches that can promise the birth of a healthy infant who requires no further treatments. Thus far, for reasons that are not currently well understood, IUTX has only been successful for treating X-SCID patients; in these studies, we will identify obstacles to IUTX success, and test novel ways of overcoming them to enable successful application of IUTx to diseases such as sickle cell disease (SCD). In addition, we created and will validate overtime a large animal model of SCD, which will be a valuable and highly clinically relevant resource for the SCD community in general.

PI_NAMEs: ALMEIDA-PORADA, GRACA DUARTE (contact);PORADA, CHRISTOPHER D

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Achievement;Acute;acute chest syndrome;Acute Disease;Adult;ALCAM gene;Allogenic;Animal Model;Animals;antibody conjugate;B-Lymphocytes;beta Globin;Biological Models;Birth;Blood;CD34 gene;Cell Separation;Cells;Characteristics;Child;Chronic;Chronic Disease;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;conditioning;curative treatments;Development;Dipeptidyl-Peptidase IV;Disease;disease model;disease phenotype;economic implication;efficacy testing;Electrophoresis;Engraftment;Exhibits;fetal;Fetal Development;Fetal Hemoglobin;fetal immunity;Fetal Sheep;Fetus;Genes;Genetic Diseases;Goals;Head;Hematological Disease;Hematopoietic Cell Growth Factors;Hematopoietic Stem Cell subsets;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;Hemoglobinopathies;Homing;Human;human disease;IL2RG gene;Immune;in utero;in utero transplantation;Incidence;infancy;Infant;Infection;Inherited;Intervention;knock-down;Life;lung injury;Medical;Modeling;Monitor;Mus;Mutation;Natural Killer Cells;Nature;NCAM1 gene;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Other Genetics;Pain;Patient Compliance;Patients;Pattern;Peptide Hydrolases;Phenotype;Play;Population Study;prenatal;Procedures;Proto-Oncogene Protein c-kit;Resistance;Resources;Risk;Role;Sheep;Sheep Diseases;sheep model;Sickle Cell;Sickle Cell Anemia;sickle cell crisis;sickling;side effect;small hairpin RNA;Solubility;somatic cell nuclear transfer;statistics;stem cell engraftment;stressor;Stroke;Stromal Cell-Derived Factor 1;success;Symptoms;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Time;translational model;Treatment Efficacy;World Health Organization

PROJECT_TITLE: Targeted conditioning to maximize prenatal HSC engraftment for SCD

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: This proposal aims to understand the brain mechanism underlying a complex cognitive behavior,  goal-directed learning. This research will significantly advance knowledge across multiple fields, including  cellular, systems, and computational neuroscience. Investigating the circuit mechanisms that coordinate  learning across multiple brain regions will identify candidate cellular and network targets for future neural  circuit-based therapeutic interventions for memory disorders.

PI_NAMEs: MILSTEIN, AARON D (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: artificial neural network;awake;Behavior;behavioral outcome;Benchmarking;Biological;Biology;Brain;Brain region;Calcium Spikes;candidate identification;Cognitive;cognitive function;Complex;computational neuroscience;Computer Models;Cues;Dendrites;design;Discrimination;Discrimination Learning;Dopamine;entorhinal cortex;Environment;experimental study;Feedback;Future;Goals;Grain;hippocampal pyramidal neuron;Hippocampus;Image;improved;in vivo;innovation;insight;Interneurons;Knowledge;Learning;learning algorithm;Location;Machine Learning;Medial;Memory;Memory Disorders;Modeling;Mus;network models;Network-based;neural circuit;neuronal circuitry;Neurons;neuroregulation;Outcome;Output;Pattern;Performance;Physiology;Population;Process;Regulation;Research;Rewards;Role;Sensory;sensory input;Sensory Process;Shapes;shot learning;Signal Transduction;Special Event;Stimulus;supervised learning;Synapses;Synaptic plasticity;synergism;System;Techniques;Testing;theories;Therapeutic Intervention;Work

PROJECT_TITLE: CRCNS: Coordinating learning by top-down gating of plasticity in dendrites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: OMAHA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Acute retinal necrosis is a viral infection of the retina with devastating complications resulting in life-long visual impairment, a worse quality of life, reduction in productivity, and can be associated with central nervous system infection and death despite rapid treatment. This project aims to provide the necessary skills to understand how the viral-innate immune response interplay unfolds within nonregenerative retinal tissue and whether there are pathways that can be targeted to improve visual outcomes following viral infection of the retina.

PI_NAMEs: CONRADY, CHRISTOPHER DALE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute Disease;Acute Retinal Necrosis Syndrome;Acyclovir;Automobile Driving;Biopsy;Blindness;Brain;career development;Cell Culture Techniques;cell type;Cells;Central Nervous System Infections;Cessation of life;chemokine;Chimera organism;Chronic Disease;Clinical Treatment;clinically significant;Cornea;cytokine;Data;Development;Development Plans;Disease;Faculty;Family;Functional disorder;fundus imaging;Future;glial activation;Goals;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Histopathology;Host Defense;Human;human tissue;Image;Immune;Immune response;Immune signaling;Immunity;improved;in vivo;Infection;Inflammation;Inflammatory;Innate Immune Response;insight;Institution;Interferon Type I;Interferons;Investigation;Knockout Mice;laboratory facility;Leucocytic infiltrate;Medical center;Meningoencephalitis;Mentors;Mentorship;Microglia;Molecular;mouse model;Mus;Natural Immunity;Nebraska;Necrosis Induction;Neurocognitive;neuroimmunology;neuroinflammation;novel;novel therapeutics;Ophthalmology;Outcome;Pathologic;Pathology;Pathway interactions;Patients;preservation;Primary Infection;Production;Productivity;Prognosis;programs;Quality of life;Research;Research Personnel;Resources;response;Retina;retinal damage;Retinal Detachment;Retinal Diseases;Retinitis;Risk;Role;Sampling;Scientist;sensor;Signal Transduction;Simplexvirus;skills;Source;Specimen;Testing;Therapeutic;Tissues;TLR3 gene;Toll-like receptors;type I interferon receptor;Universities;vaginal mucosa;Viral;Virus;Virus Activation;Virus Diseases;Virus Replication;Vision;vision science;Visual;Visual impairment;Wild Type Mouse

PROJECT_TITLE: Innate Immunity to Viral Infection of the Retina


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Pediatric acute respiratory distress syndrome is a life-threatening and frequent problem experienced by thousands of children each year. In severe pediatric acute respiratory distress, little evidence substantiates current supportive practices. The overall objective of this study is to compare short and long-term patient outcomes in two groups of children: one group managed with a mechanical ventilation protocol that reserves the use of extracorporeal membrane oxygenation (ECMO) until protocol failure to another group supported on ECMO per usual care.

PI_NAMEs: BARBARO, RYAN PASQUALE (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Address;Age;Anticoagulation;artificial lung;Blood;blood pump;Body System;Brain;Breathing;Cannulas;Child;Child Support;Childhood;Clinical;Clinical Trials;Communication;comparative effectiveness study;conventional therapy;Critically ill children;Data;Data Collection;Data Element;Equipoise;Evaluation;experience;Extracorporeal Membrane Oxygenation;Failure;Family;Fatigue;Frequencies;functional outcomes;functional status;Funding;Guidelines;health related quality of life;Hemorrhage;Impairment;instrument;Intervention;Knowledge;Life;longitudinal, prospective study;Measures;Mechanical ventilation;Mechanical Ventilators;mental state;Morbidity - disease rate;mortality;Motor;National Heart, Lung, and Blood Institute;Nervous System Trauma;neurodevelopment;Nutritional Support;Organ failure;Outcome;Outcome Study;Oxygen;Patient-Focused Outcomes;Pediatric Acute Respiratory Distress Syndrome;Positioning Attribute;preservation;Prone Position;prospective;Protocols documentation;Pump lung;Quality of life;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Registries;respiratory;response;Sensory;Site;Stroke;Supination;Support Groups;systematic review;Techniques;Testing;treatment as usual;Uncertainty;ventilation;Ventilator;Ventilator-induced lung injury

PROJECT_TITLE: ASCEND (ARDS in Children and ECMO initiation strategies impact on Neuro-Development)

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE T cell immunotherapy focused on effector T cells has revolutionized cancer treatment. We and others have recently discovered that naïve T cells – the primordial substrate of T cell immunity – exist in distinct transcriptional states, which in turn dictates their capacity to become effector T cells. Here, we propose to test the transformative hypothesis that these naïve T cell archetypes can be modified (induced, expanded, contracted) by the type of microbial exposure (i.e.: bacteria, viruses, helmiths) and thus be programmed to become better at mounting anti- tumor immunity.

PI_NAMEs: GHOSH, SOURAV ;ROTHLIN, CARLA  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;adaptive immune response;adaptive immunity;Admixture;anti-PD-1;anti-tumor immune response;Antigens;Automobile Driving;Bacteria;Bacterial Infections;Calibration;cancer cell;cancer infiltrating T cells;Cancer Model;cancer therapy;Cataloging;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;cell killing;Cells;Cellular Immunity;Citrobacter rodentium;Complex;Contracts;effector T cell;Elements;engineered T cells;Environment;Equilibrium;exhaustion;experience;Frequencies;Future;Gene Expression;Genes;Genetic;genetic risk factor;Genetic Transcription;germ free condition;Growth;helminth infection;Helminths;Heterogeneity;Host Defense;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune response;Immune system;Immunity;Immunoglobulin Domain;immunoregulation;Immunotherapy;Implant;improved;Induced Mutation;Infection;Innate Immune Response;innovation;Interferon Type I;Interleukin-4;Lymphocytic choriomeningitis virus;Malignant neoplasm of liver;Melanoma;Memory;microbial;Modeling;Molds;mouse model;Mus;Nature;Nippostrongylus;novel;pathogen;pathogen exposure;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;Population;prevent;Proliferating;Regulatory T-Lymphocyte;repository;response;Role;Self-Injurious Behavior;Shapes;Signal Transduction;Simian virus 40;Source;Suppressor-Effector T-Lymphocytes;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Translating;Transplantation;tumor;Tumor Antigens;tumor growth;Tumor Immunity;Virus;Virus Diseases

PROJECT_TITLE: Naïve T cell archetypes and anti-tumor immunity

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]