FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: MADISON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARATIVE Despite a long history of groundbreaking discoveries, the number of funded surgeon-scientists continues to drop precipitously. Evidence supports a two-year research experience as part of general surgery residency to increase the likelihood that surgeons will pursue academic careers, and the integration of PhD-scientists into Departments of Surgery as a means of promoting surgical research productivity. Utilizing these two approaches, the University of Wisconsin Surgical Oncology Research Training (UW-SORT) Program aims to train post-doctoral fellows who will pursue multidisciplinary, translational surgical oncology research and ensure our continued advancement in the care of patients with cancer.

PI_NAMEs: NEUMAN, HEATHER B (contact);XU, WEI

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Research Training;Surgical Oncology;Training Programs

PROJECT_TITLE: UW Surgical Oncology Research Training Program (UW-SORT)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative: Improper drainage of extravasated protein-rich fluid from the thoracic tissues causes it to accumulate, resulting in chylothorax. It is the most common lymphatic anomaly and frequently involves defective lymphatic development in newborn children. Our exciting findings reveal a novel function of common oncogenic mutation during thoracic lymphatic development. The set of experiments outlined in this proposal will reveal critical molecular mechanisms underlying lymphatic development and disease.

PI_NAMEs: TRIVEDI, CHINMAY M (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Affect;Alveolus;arteriole;Automobile Driving;Basement membrane;Bilateral;Biology;Birth;Blood Vessels;Cells;Characteristics;Chest;Chromatin;Chyle;Chylothorax;Collagen;Connective Tissue;Consensus;crosslink;Cyanosis;Cytoplasm;Death Rate;Defect;Deposition;Development;Diagnosis;Drainage procedure;effective therapy;effusion;Embryo;Endothelium;epigenetic regulation;Etiology;Exhibits;experimental study;Extravasation;Fluid Balance;gain of function mutation;Gases;Genes;Genetic;Genetic Transcription;genome-wide;Homeostasis;Human;human model;Impairment;improved;KRAS2 gene;KRASG12D;Laminin;Link;Liquid substance;Lung;Lung Compliance;lung maturation;Lymphangiectasis;Lymphatic;lymphatic development;Lymphatic Diseases;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic function;lymphatic malformations;Lymphatic System;lymphatic vasculature;lymphatic vessel;MAP Kinase Gene;MAPK Signaling Pathway Pathway;MAPK1 gene;Mechanics;Membrane Proteins;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutation;Neonatal;Neonatal lung;neonatal mice;neonatal patient;Newborn Infant;Nidogen;novel;Nuclear;Oncogenic;organ growth;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Pleura;Pleural;Pleural effusion disorder;postnatal;prenatal;prevent;programs;Proteins;recruit;Regulation;Regulatory Element;Repression;Research;Respiratory distress;Respiratory Failure;Role;Signal Pathway;Signal Transduction;Somatic Mutation;Structure;Structure of respiratory bronchiole;Terminal Bronchiole;Testing;Tissue Sample;Tissues;transcription factor;Transcriptional Regulation;Vascular Diseases;venule

PROJECT_TITLE: Epigenetic regulation of lymphatic development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative High throughput sequencing of the rearranged T cell receptor genes (HTS) is an approach that profiles T cells in the tissue and has enhanced the ability to diagnose and manage patients with cutaneous T cell lymphoma (CTCL). However, the formalin used to preserve skin biopsy specimens damages DNA and affects readings in a way that could lead to errors in patient diagnosis and care. We seek to identify new fixatives and tissue handling procedures that enable multiple different analyses to be accurately carried out on small skin biopsies obtained in CTCL clinical trials, including HTS readings, histologic studies and measures of gene expression.

PI_NAMEs: CLARK, RACHAEL ANN (contact)

PROGRAM_OFFICER_NAME: RAO, ABHI

PROJECT_TERMS: Affect;Age;Biological Assay;Biological Markers;Biometry;Biopsy;Biopsy Specimen;Blood;cancer type;Caring;Cell Count;Clinical;Clinical effectiveness;Clinical Trials;Collection;Cutaneous Lymphoma;Cutaneous T-cell lymphoma;Data;Dermatology;Diagnosis;Disease;Disease Progression;disorder risk;DNA;DNA Damage;Epitopes;Fixatives;Formalin;Freezing;Future;Gel;Gene Expression;Genes;Goals;High-Throughput Nucleotide Sequencing;Histologic;histological studies;Histology;Human;Immunology;Immunotherapy;indexing;Industrialization;Industry;innovation;lymph nodes;Malignant - descriptor;Measurement;Measures;next generation;Non-Hodgkin's Lymphoma;Nucleic Acids;Oncology;Pathology;Patients;Performance;phase III trial;Placebo Control;preservation;Procedures;Proteins;Randomized;Reproducibility;resiquimod;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Sampling;Skin;skin biopsy;skin lesion;Specimen;T cell receptor repertoire sequencing;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Techniques;Temperature;Testing;Time;Tissue Banks;tissue processing;Tissues;treatment response;tumor

PROJECT_TITLE: Optimizing pre-analytic sample handling for high throughput TCR sequencing in cutaneous T cell lymphoma


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Transgender and gender diverse (TGD) people experience a range of mental health disparities largely understood in the context of gender minority stress. We propose to develop a culturally sensitive, multidimensional measure of TGD resilience, and to use our scale to investigate the role of resilience in buffering the effect of minority stressors in a longitudinal study. The proposed project is poised to broaden our conceptualization and measurement practices for TGD Resilience, reframe the overall approach to TGD health-disparities research to incorporate a strengths-based focus, and inform the development of targeted mental health interventions to bolster TGD resilience.

PI_NAMEs: GALUPO, PAZ ;MATSUNO, EM ;PUCKETT, JULIA  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Age;anxiety symptoms;Area;Attention;Birth;Buffers;Categories;Characteristics;cisgender;Clinical;Communities;community advisory board;community based participatory approach;Computers;Conscious;Data;Data Collection;depressive symptoms;Development;Dimensions;Discrimination;Disparity;Evaluation;expectation;experience;Exposure to;Factor Analysis;Feedback;Focus Groups;follow-up;Gender;gender diverse;Gender Identity;gender minority stress;harassment;healing;Health;Health Disparities Research;health disparity;improved;Individual;interest;Intervention;Israel;longitudinal design;Longitudinal Studies;Maps;Measurement;Measures;Mental Health;Methods;Minority Groups;minority health;minority health disparity;Minority Health Research;minority stress;minority stressor;Modeling;National Institute on Minority Health and Health Disparities;nonbinary;novel;Outcome;Participant;peer;people of color;Persons;promote resilience;prospective;protective factors;Psychometrics;Qualitative Research;Race;racial population;recruit;Reporting;Research;Research Design;research study;resilience;resilience factor;resilience research;resilience scale;response;Risk;Role;sex assigned;social culture;Stress;stressor;Structure;Suicide attempt;Surveys;Testing;Theoretical model;therapy development;Time;transgender;transgender men;transgender women;Validity and Reliability;Violence;Work

PROJECT_TITLE: Modeling Resilience as a Multidimensional Protective Factor for Transgender Health Disparities: Measure Development and Longitudinal Evaluation of Resilience

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PI_NAMEs: THOMAS, DANNY GEORGE (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TERMS: Academic Medical Centers;Behavior Therapy;biomedical scientist;career;Clinical;Clinical Research;Communication;Communities;Development;Development Plans;Doctor of Philosophy;doctoral student;Educational process of instructing;Educational workshop;Environment;experience;Goals;graduate student;Grant;Health;high school;Human;improved;Individual;Intervention;Leadership;Manuscripts;Mentors;National Research Service Awards;next generation;Outcome;Physicians;Population;population health;programs;Research;Research Project Grants;Science;Scientist;skill acquisition;skills;student participation;Students;symposium;Therapeutic;Training;Translational Research;translational research program;undergraduate student;Writing

PROJECT_TITLE: J. NRSA Training Core


ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative This proposal will examine the efficacy of novel bone-directed therapies blocking key interactions of cancer cells with the tumor microenvironment to decrease tumor growth, control dormant cancer cells, repair damaged bone, and circumvent unwanted systemic toxic effects in multiple myeloma. Successful completion of this project could provide new approaches to guide development of new therapies that prevent or delay disease relapse and improve bone health in myeloma patients.

PI_NAMEs: DELGADO-CALLE, JESUS  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;antagonist;Antibody Therapy;bone;Bone Diseases;bone health;Bone Marrow;Bone Pain;bone preservation;bone repair;Bone Resorption;Bone Resorption Inhibition;Bone Resorption Stimulation;Brain;cancer cell;Cells;chemotherapeutic agent;Clinic;Communication;Development;Disease;Dose;Drug Kinetics;efficacy evaluation;fracture risk;gamma secretase;Genetic;Goals;Growth;healing;Hematologic Neoplasms;Homeostasis;Immunocompetent;Immunosuppression;improved;In complete remission;In Vitro;in vivo;inhibitor;innovation;Intestines;Lytic Lesion;Lytic Metastatic Lesion;Malignant - descriptor;Mediating;Medical;Metastatic Neoplasm to the Bone;Minor;Morbidity - disease rate;mortality;mouse model;Multiple Myeloma;Mus;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;notch protein;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteolytic;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Plasma Cells;Play;pre-clinical;prevent;Prevention;Proliferating;Property;Recurrent disease;relapse prevention;repaired;Role;Safety;side effect;Signal Pathway;Signal Transduction;skeletal;targeted treatment;Testing;therapy resistant;Tissues;tool;Toxic effect;Toxicology;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;WNT Signaling Pathway;Work

PROJECT_TITLE: Bone-Targeted Therapies to Improve Bone Health and Prevent Relapse in Multiple Myeloma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Infectious Diseases;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE The objective of this research is to develop, validate, and implement advanced computational tumor phenotyping strategies to characterize treatment response of head and neck cancer and evaluate the role of the immune system in therapeutic resistance. Our approach involves the high-throughput analysis of quantitative features from both radiology images (i.e., radiomics) and digital pathology images (i.e., pathomics) to generate tumor- specific computational fingerprints of disease at the macroscopic-scale and microscopic-scale, respectively. We hypothesize that by leveraging innovative computing strategies, novel clinical trial data, and complementary mechanistic experiments, we can link radiopathomic expression patterns to biological processes driving treatment resistance, which may guide improved treatment approaches for this urgent and unmet clinical need.

PI_NAMEs: LAFATA, KYLE  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Alcohol consumption;Automobile Driving;Behavior;Biological;Biological Markers;Biological Process;Biology;biomarker discovery;biomarker identification;candidate marker;Carcinogens;Cell Communication;Cells;Cessation of life;Characteristics;chemoradiation;chemotherapy;Cisplatin;Clinical;Clinical Trials;clinically relevant;Combined Modality Therapy;computational platform;Data;data modeling;Development;digital pathology;Disease;disease prognosis;Dose;Enrollment;Evaluation;Exhibits;experimental study;External Beam Radiation Therapy;Fingerprint;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Gene Expression;Genes;Genetically Engineered Mouse;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Heterogeneity;high throughput analysis;HPV negative;HPV oropharyngeal cancer;HPV positive;human model;Human papilloma virus infection;Human Papillomavirus;Image;image guided;Immune;immune cell infiltrate;Immune response;Immune system;Immunotherapy;improved;Inflammation;innovation;insight;Intervention Studies;knockout gene;Knowledge;Link;Location;Lymphocyte;Malignant Neoplasms;mathematical model;Measurement;Measures;Metabolic;Microscopic;Modeling;Molecular;mouse model;Mus;neutrophil;novel;Oncology;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Outcome;participant enrollment;pathology imaging;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;personalized medicine;Phenotype;Play;Positron-Emission Tomography;potential biomarker;Precision therapeutics;Process;prognostic assays;prognostic value;Progression-Free Survivals;prospective;radiation resistance;Radiation therapy;radiological imaging;radiomics;Research;Resistance;response;Role;Science;success;Techniques;Testing;Therapeutic;therapy resistant;Time;time interval;Tissue Sample;Tobacco use;tool;transcriptomics;treatment response;treatment strategy;tumor;tumor immunology;tumor microenvironment;Tumor Volume;tumor-immune system interactions;uptake

PROJECT_TITLE: Computational tumor phenotyping to interrogate treatment resistance and immune dysregulation in head and neck cancer

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Postpartum depression (PPD) is a common and often devastating complication of childbirth that disproportionately affects black, indigenous, people of color (BIPOC) mothers. Expanding our existing MomGenes Fight PPD study will allow us to collect robust phenotypes and biological samples for a large number of BIPOC women to more completely understand PPD risk factors. Our examination of genetic, adverse life events, and discrimination burden can lead to actionable findings that aid all women suffering from PPD.

PI_NAMEs: GUINTIVANO, JERRY  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Affect;Agreement;Biological;Biomedical Research;Black, Indigenous, People of Color;Childbirth;cohort;Complex;Complication;critical developmental period;Data;depressive symptoms;Development;Discrimination;Disease;Disparity;DNA Methylation;Early Diagnosis;Environment;Environmental Risk Factor;Etiology;European ancestry;Event;experience;fighting;follow-up;functional genomics;Gender;Genetic;genetic analysis;Genetic Risk;genetic risk factor;genetic variant;Genome;genome wide association study;genomic data;genomic locus;Genomics;Genotype;health care availability;health disparity;Healthcare;Heritability;Hypothalamic structure;improved;Individual;Life;Maps;Medical;Medicine;Mendelian randomization;Mental disorders;Mental Health;Mental Health Services;Mentored Research Scientist Development Award;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;mortality;Mothers;National Institute of Mental Health;Natural Disasters;Neurons;offspring;Outcome;Participant;people of color;personalized medicine;Pharmaceutical Preparations;Phenotype;physical abuse;Postpartum Depression;predictive modeling;Prevalence;prevent;psychiatric comorbidity;Public Health;Race;Recontacts;recruit;Religion;Research;Risk;Risk Factors;Sample Size;Sampling;secondary analysis;Sex Orientation;Sexual abuse;social stigma;societal costs;success;suicidal behavior;Symptoms;Thalamic structure;Tissues;trait;transcriptome sequencing;United States;Variant;Weight;Woman;women of color;Women's study;Work

PROJECT_TITLE: MomGenes Fight PPD: Expanding to Increase Participation from Diverse Ancestries

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Throughout development, microRNAs are used to regulate gene expression, and cancers can form throughout the body when that control is lost. This project studies how loss of microRNAs causes pediatric brain tumors by dysregulating factors that control gene expression during brain development.

PI_NAMEs: CHEN, KENNETH SUNG-MAN (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Ablation;Adult;Affect;Automobile Driving;Binding;Binding Sites;Brain;Cancer Etiology;cancer type;CCND2 gene;CDK4 gene;Cell Line;Childhood Brain Neoplasm;Chromatin;Collaborations;Data;derepression;Development;DICER1 gene;Differentiated Gene;DNA Binding;Embryo;embryonic stem cell;Enzymes;Exhibits;Family;Future;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic;genetic approach;Genomic Segment;Growth;Human;human model;Impairment;In Vitro;in vivo;Kidney;Lung;Malignant Childhood Neoplasm;Malignant Neoplasms;member;MicroRNAs;Modeling;mouse model;Mus;mutant;Mutation;Neuroendocrine Tumors;Oncogenes;Oncogenic;Ovary;overexpression;Pathway interactions;Patients;Pineal gland;Pineal Gland Neoplasm;pineoblastoma;Play;progenitor;Proliferating;Prostate;prostate cancer cell line;Repression;restraint;Retina;RNASE3L gene;Role;small molecule;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;transcription factor;tumor;tumorigenesis;Undifferentiated;Up-Regulation;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Developmental transcription factors in Drosha-driven cancer

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Human spermatogonial stem cells (SSCs) are at the foundation of spermatogenesis and may have applications for treating certain groups of infertile patients. However, progress translating stem cell methods to the human fertility clinic are hampered by our limited knowledge of the regulatory mechanisms of SSC functions in the human testis and lack of tools to isolate, manipulate and expand stem cells for basic research or therapeutic applications. Our proposed work will provide much needed insights into the functional interplay between stem cells and their surrounding microenvironment, which will be crucial to the development of methods to maintain and expand human SSCs in long-term culture.

PI_NAMEs: CHEN, HAIQI  (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Basic Science;Cancer Patient;Catalogs;Cell Communication;cell type;Cells;Clinic;comparative;Comparative Study;Coupled;Data;Data Set;Dissection;Endothelin;Endothelin-1;Ephrin-A1;Ephrins;Etiology;Fertility;fertility preservation;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Flow Cytometry;Foundations;Gene Expression;Genetic Models;genome-wide;Germ Cells;glial cell-line derived neurotrophic factor;Goals;Healthcare;Human;human adult stem cell;In Vitro;in vivo;Individual;Infertility;insight;Knowledge;life span;Ligands;male;Male Infertility;Malignant Neoplasms;Maps;Mediating;method development;Methods;Modeling;Molecular;Molecular Analysis;mouse model;Mus;neurturin;novel;novel strategies;Patients;Process;Production;Proto-Oncogene Protein c-kit;receptor;Receptor Signaling;receptor-mediated signaling;Regulation;reproductive;Research;RNA;Rodent;Role;self-renewal;Series;Signal Pathway;Signal Transduction;Signaling Molecule;Somatic Cell;Spermatogenesis;stem cell expansion;stem cell function;stem cell niche;stem cell self renewal;stem cells;System;Testing;Testis;Therapeutic;Tissues;tool;transcriptomics;Translating;Work;Xenograft procedure

PROJECT_TITLE: Spatially Resolved, Functional Dissection of the Human Spermatogonial Stem Cell Niche

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative  The goal is to develop an integrated deep learning model to optimize 5'UTR, codon usage, and 3'UTR at same time that enables users to design the optimal mRNA sequence to enhance protein expression level, thus to improve the efficacy of mRNA medicines. mRNA based therapies hold great promise for the treatment of various types of diseases, but this therapeutic approach suffers from multiple challenges including the short half- life of exogenously administered mRNA and subsequent protein production. Our proposed studies will address the challenges in design of mRNA sequence to enhance mRNA stability and translation efficiency, and thus provide important information for the development and optimization of mRNA vaccines.

PI_NAMEs: ZHOU, XIAOBO  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;5' Untranslated Regions;Affect;Antigens;Atlases;Biology;cell type;Cells;Clinical;clinical application;Clinical Trials;Codon Nucleotides;Communicable Diseases;Communities;Computer software;COVID-19 vaccine;Data;Data Set;Databases;deep learning;deep learning model;design;Development;Disease;Effectiveness;egg;Encapsulated;Face;Future;Generations;Genes;Genetic Diseases;Genotype-Tissue Expression Project;Globin;Goals;Half-Life;Hemagglutinin;Hemoglobin;Human;Immunity;imprint;improved;in silico;In Vitro;in vivo;Individual;Influenza;Influenza A virus;Influenza B Virus;influenza virus strain;influenza virus vaccine;influenzavirus;Injections;Intramuscular Injections;lipid nanoparticle;Malignant Neoplasms;manufacture;Medicine;Messenger RNA;Methodology;MicroRNAs;model design;Modeling;Moderna COVID-19 vaccine;mRNA Stability;mRNA Translation;Muscle;Mutation;Nipah Virus;novel;Open Reading Frames;Organ;pandemic disease;Pathogenicity;Performance;Pfizer-BioNTech COVID-19 vaccine;Poly(A) Tail;pre-clinical;preservation;Preventive measure;Preventive vaccine;Production;protein expression;Proteins;Proteomics;prototype;Public Health;Recombinants;Research;Research Personnel;respiratory pathogen;Respiratory syncytial virus;RNA;RNA Stability;RNA vaccine;Role;Safety;screening;seasonal influenza;Speed;Structure;success;Techniques;Technology;Testing;Therapeutic;Time;Tissues;tool;Translations;Untranslated Regions;vaccine efficacy;Vaccinee;Vaccines;Viral Proteins;Virus;Visualization;web site;Zika Virus

PROJECT_TITLE: Developing mRNAdesigner tool package for optimization of mRNA sequence

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


PHR: Project Narrative This R01 application will focus on the development of tumor-activatable IL-2 superkine nanoparticles for cancer immunotherapy. Delivery of Rb-tropic, acidity-resistant IL-2 superkine by UPS nanoparticles will effectively mask the systemic toxicity in normal tissues while achieving robust activation of cytotoxic lymphocytes in tumors for efficacious therapy.

PI_NAMEs: GAO, JINMING  (contact);HUANG, GANG

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acidity;Acids;Adoption;Affinity;Albumins;Aldesleukin;Antitumor Response;Artificial nanoparticles;Binding;cancer immunotherapy;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Clinical;cytokine;cytokine therapy;cytotoxic;Data;design;Detection;Development;Dose Limiting;efficacious treatment;efficacy outcomes;FDA approved;Functional disorder;Goals;Half-Life;Immune;immune activation;Immune Tolerance;Immunotherapy;improved;Indocyanine Green;Interferons;Interleukin 2 Receptor;Interleukin Activation;Interleukin-2;invention;Libraries;Lymphocyte;Masks;Metabolic;Micelles;Mus;Mutation;mutein 2;nanoparticle;nanoprobe;Natural Killer Cells;neoplastic cell;NK Cell Activation;Normal tissue morphology;Outcome;Pharmaceutical Preparations;phase II trial;Phase Transition;Play;Protein Engineering;Proteins;receptor;Regulatory T-Lymphocyte;Rejuvenation;Renal Carcinoma;Research;Resistance;response;Role;Safety;Serum;Skin Cancer;Sodium Lactate;stem;synergism;systemic toxicity;T-Cell Proliferation;Testing;therapeutic nanoparticles;Toxic effect;Tropism;tumor;tumor eradication;Tumor Immunity;tumor microenvironment;Waste Products

PROJECT_TITLE: Tumor-activatable Interleukin-2 Superkine Nanoparticle Therapy

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Orphan Drug;Precision Medicine;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative The proposed research is relevant to public health because discovery of therapy for APOL1-associated kidney disease will reduce the incidence of end stage kidney disease and associated costs and mortality, and mitigate racial disparities in kidney health in the U.S., which is within the mission of NIDDK.

PI_NAMEs: OLABISI, OPEYEMI AYODEJI (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Address;African;African American;African American population;Albumins;American;Apolipoproteins;Caring;causal variant;Cells;Chronic Kidney Failure;Church;Clinical;clinical predictors;clinical trial in a dish;Clinical Trials;Code;Colorectal Cancer;Communities;community engaged approach;community engagement;cost;Creatinine;Creativeness;Data;Development;Diagnosis;Disease;Disparity;disparity reduction;effective therapy;efficacy study;efficacy testing;End stage renal failure;Enrollment;European;Failure;Financial cost;Focal and Segmental Glomerulosclerosis;Future;Genes;Genotype;glomerular filtration;Glomerular Filtration Rate;Goals;Health;health disparity;Hemoglobin;high risk;Human;Hypertension;in vivo;Incidence;Individual;individualized medicine;induced pluripotent stem cell;inhibitor;Injury;Injury to Kidney;innovation;Interferon Type II;JAK1 gene;JAK2 gene;Kidney;kidney biopsy;Kidney Diseases;Laboratories;Malaria;Malignant Breast Neoplasm;men;Mission;Modeling;mortality;Mutation;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Immunity;Nephrology;novel;Outcome;Participant;Pathway interactions;patient derived induced pluripotent stem cells;patient oriented research;Patients;personalized medicine;personalized therapeutic;Persons;Pharmaceutical Preparations;Phase;phase III trial;Phosphotransferases;Placebos;podocyte;Population;Potassium;Prediction of Response to Therapy;predictive tools;primary endpoint;programs;protective effect;Proteins;Proteinuria;Public Health;racial disparity;Randomized;randomized trial;randomized, clinical trials;Research;response;Risk;risk variant;Safety;safety assessment;screening;Sickle Hemoglobin;Signal Transduction;targeted treatment;Testing;theories;Therapeutic Trials;tool;Translational Research;treatment response;Trypanosoma;urinary;Validation;Variant;Woman;years of life lost

PROJECT_TITLE: JAK-STAT Inhibition to Reduce Racial Disparities in Kidney Disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: JACKSON

ORG_DEPT: BIOLOGY

ORG_NAME: JACKSON STATE UNIVERSITY

ORG_STATE: MS

PHR: PROJECT NARRATIVE (Overall Section) Jackson State University proposes to establish a RCMI Center for Health Disparities Research (RCHDR) to conduct innovative research to advance the science of health disparities through strategic investments in critical research infrastructure, community engagement, and training/building a critical mass of biomedical scientists to address important health disparities issues of concern to vulnerable and underserved communities. The Center is highly committed to implement innovative research to improve minority health and reduce health disparities in Mississippi.

PI_NAMEs: PAYTON, MARINELLE  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Affect;Area;Behavioral Research;Biomedical Research;biomedical scientist;career;career development;clinical center;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;community academic partnership;community engagement;community organizations;Community Participation;community research;cost;Data;design;Development;disease disparity;Ecosystem;Educational workshop;Environment;Equipment;Evaluation;Faculty;Fostering;Foundations;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;improve minority health;improved;Infrastructure;innovation;Institution;instrument;Investments;Knowledge;Laboratories;laboratory experience;Learning;Logic;Mainstreaming;Malignant Breast Neoplasm;Malignant Neoplasms;Mentors;minority communities;Mississippi;Modeling;Monitor;new technology;next generation;novel;operation;Pilot Projects;Procedures;Process;Productivity;programs;Pulmonary Fibrosis;Recovery;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;responsible research conduct;Science;Series;Services;skills;Social Behavior;Specialized Center;Strategic Planning;success;symposium;System;Technical Expertise;Techniques;Time;Training;translational potential;Translational Research;underserved community;United States National Institutes of Health;Universities;vulnerable community;web site;Writing


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE (Administrative Core)  The primary function of the Administrative Core (AC) of the RCHDR is to provide oversight of all RCMI  program activities including fiscal, budgetary, organizational, planning, evaluation, infrastructure development,  and technology transfer. The AC is responsible for the general administration and coordination of all  programmatic activities and the efficient operation of Research Infrastructure Core, Community Engagement  Core, and Investigator Development Core. The AC is also responsible for coordinating the activities of both  internal and external advisory committees, conducting regular assessments to evaluate the Center and identify  needs and opportunities, and creating an integrated work environment that fosters the development and  implementation of innovative research aimed at improving minority health and reducing health disparities.

PI_NAMEs: TCHOUNWOU, PAUL B. (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Basic Science;Behavioral Research;Biomedical Research;career;career development;Clinical Research;Collaborations;Communication;community engagement;cost effective;Data;Development;Ensure;Environment;Evaluation;Extramural Activities;Faculty;forging;formative assessment;Fostering;Funding;Goals;Health;Health Disparities Research;health disparity;implementation facilitation;improve minority health;improved;Infrastructure;infrastructure development;innovation;insight;Interdisciplinary Study;Leadership;Link;Logic;member;Mentors;minority investigator;Mission;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Occupational activity of managing finances;operation;Outcome;Output;Process;Productivity;professional atmosphere;programs;Recommendation;Reduce health disparities;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;skills;Specialized Center;Strategic Planning;Structure;Technology Transfer;Translational Research;underserved community;United States National Institutes of Health;Universities;vulnerable community;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE (Research Infrastructure Core)  In this U54 grant proposal, we propose the consolidation of existing multiuser core laboratories to create a  comprehensive Research Infrastructure Core (RIC) that will accelerate discoveries in basic, clinical and/or  translational sciences, in an effort to address important health disparity issues of concern to minorities and  underserved communities. The proposed RIC will provide RCHDR investigators and the scientific community  at JSU with a robust, collaborative, and standardized resource for the efficient implementation of their  biomedical research projects. This strategic plan fully supports the RCHDR vision of developing a state-of-the-  art biomedical infrastructure that enables JSU investigators to become more competitive in obtaining research  grants from NIH and/or other funding agencies.

PI_NAMEs: STEVENS, JACQUELINE JEANETTE (contact)

PROJECT_TERMS: Acceleration;Address;Animals;Applications Grants;Area;Basic Science;Behavior;Behavioral Research;Bioinformatics;Biomedical Research;Biometry;Cancer Biology;Career Mobility;catalyst;Clinical Research;Clinical Sciences;Collaborations;Communities;Core Facility;cost effective;cost effectiveness;Cost effectiveness research;Data Analyses;Data Collection;design;Development;Educational workshop;Environment;Equipment;Facility Accesses;Fostering;Funding;Funding Agency;Future;Goals;Health Disparities Research;health disparity;human disease;Human Resources;improve minority health;Incidence;Infrastructure;innovation;Institution;instrumentation;interdisciplinary collaboration;Interdisciplinary Study;knowledge base;Laboratories;Laboratory Research;Malignant Neoplasms;Mentors;Methodology;minority communities;Modernization;Molecular and Cellular Biology;new technology;novel;operation;Outcomes Research;Pilot Projects;Prevalence;prevent;Productivity;Professional Organizations;programs;Reduce health disparities;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;research vision;Resources;Services;skills;Standardization;Strategic Planning;Teacher Professional Development;Technical Expertise;Techniques;Technology;Therapeutic;Toxicogenomics;Training;Translational Research;underserved community;United States National Institutes of Health;Universities;vulnerable community

PROJECT_TITLE: Research Infrastructure Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE (IDC)  The major goal of RCMI-CHDR Investigator Development Core (IDC) is to provide early stage investigators  (ESI) with the necessary resources and support mechanisms to facilitate their transition to independent  researchers. The IDC will implement an effective Pilot Project Program (PPP) that will catalyze the scientific  growth and professional development of ESI by: (1) supplying pilot funding for the implementation of basic  science, behavioral and/or clinical research aimed at improving minority health and reducing environmental  health disparities; and (2) engaging ESI in a rigorous biomedical research-training program that fosters  mentoring and academic career development.

PI_NAMEs: TURNER, TIMOTHY  (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Applications Grants;Appropriateness Review;Award;Basic Science;Behavioral Research;Biomedical Research;biomedical scientist;career;Career Choice;career development;Clinical Research;Collaborations;Communities;Coupled;Data;design;Development;Development Plans;disease disparity;Educational workshop;Ensure;Environmental Health;environmental health disparity;Evaluation;Extramural Activities;Faculty;Financial Support;forging;Fostering;Funding;Funding Opportunities;Goals;Growth;Health Disparities Research;health disparity;improve minority health;infrastructure development;innovation;Institution;interest;Investments;Journals;Laboratories;Letters;Measures;meetings;member;Mentors;Mentorship;minority communities;Minority Groups;Modification;Monitor;novel;Outcome;Peer Review;Persons;Pilot Projects;Postdoctoral Fellow;Process;Productivity;professor;Program Development;Program Reviews;programs;Publications;Recommendation;Request for Applications;Research;Research Personnel;Research Project Grants;Research Proposals;Research Training;Resources;responsible research conduct;Review Committee;Series;Sorting;symposium;Training;Training Programs;underserved community;Underserved Population;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE (CEC)  The RCMI Center Health Disparities Research (RCHDR) Community Engagement Core (CEC) plays a critical  role in ensuring the bidirectional communication between investigators and the various advocacy groups and  community organizations in order to implement cost-effective strategies to address critical health disparities  issues in the tri-county area (Hinds, Madison and Rankin counties) surrounding the capital city of Jackson,  Mississippi. It is a community-university partnership designed to improve minority health and reduce health  disparities. The establishment of a Community Advisory Board (CAB) composed of community leaders,  scientists, government officials and state agencies, faith-based organizations, and several grassroots health  organizations creates a supportive framework to achieve this goal.

PI_NAMEs: ANTOINE-LAVIGNE, DONNA A (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Area;Awareness;Basic Science;Behavior;Behavioral Research;Biomedical Research;Capital;catalyst;Cities;Clinical Research;Collaborations;Communication;Communications Media;Communities;community academic partnership;community advisory board;community based participatory research;community based practice;community engaged research;community engagement;Community Health;community involvement;community organizations;Community Participation;community partners;cost effective;County;design;Disease;disease disparity;Education;Educational Materials;Educational workshop;Ensure;evidence base;Faith-based organization;Fostering;Goals;Government Officials;Health;Health Disparities Research;health disparity;Health education;health knowledge;health organization;Health Priorities;improve minority health;improved;Incidence;Journals;Knowledge;learning community;meetings;member;minority communities;minority health;Mississippi;novel;outreach;Participant;Pilot Projects;Play;Population;Prevalence;Prevention;Process;Productivity;programs;Publications;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Role;Scientist;Site;social media;symposium;Technology Transfer;tool;Training;Translational Research;Translations;underserved community;underserved minority;Vulnerable Populations;web site;Work

PROJECT_TITLE: Community Engagement Core


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Latinx adolescents are disproportionately at risk for poor depression and suicidality and are exposed to adversity, stress, and discrimination experiences. There remains a need for research understanding the effect of laws and policies on Latinx youth mental health to broaden the scope of prevention and intervention focused on upstream factors. The proposed study fills this gap by using rigorous methodology to examine the influence of macrolevel policies on Latinx youth mental health and to inform effective community-engaged strategies.

PI_NAMEs: VILLAMIL GREST, CAROLINA  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Academy;Adolescence;Adolescent;Affect;Alcohol consumption;Applications Grants;Area;Behavioral;behavioral health;Black race;career;career development;Childhood;cocaine use;Communities;community based participatory approach;community engaged approach;community engaged intervention;community engaged research;community engagement;critical developmental period;Data Set;depressive symptoms;design;Development;Development Plans;Dimensions;Discrimination;dissemination strategy;effective intervention;Environment;Epidemiology;experience;Exposure to;Family;Feeling suicidal;Goals;Health;Health behavior;health disparity;health equity;Health Promotion;Immigrant;Immigration;Individual;Inequity;Institution;interdisciplinary collaboration;Intervention;Latinx;Latinx population;Laws;Legal;Maps;marijuana use;Medicine;Mental Depression;Mental Health;Mental health promotion;Mentors;Methodology;Methods;Parents;Pathway interactions;peer;perceived discrimination;Personal Satisfaction;Persons;Policies;Population;Prejudice;Prevention;Prevention program;Prevention strategy;programs;protective factors;Public Health;Public Policy;Quasi-experiment;Recommendation;Reduce health disparities;Research;Research Personnel;Resources;Risk;Risk Behaviors;Role;Shapes;skills;social;social culture;Social Environment;social factors;social health determinants;Stress;structural determinants;Structure;substance use;success;suicidal;symposium;Testing;therapy design;Training;Translational Research;United States National Institutes of Health;Universities;Youth

PROJECT_TITLE: Policy as a Structural Barrier and Facilitator of Latinx Youth Mental Health


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Narrative  This study proposes a novel mechanism of how cancer cells fuse with other cells, an event that could explain  how cancer cells move from their original location to other sites in the body and form new tumors or  metastases. The results from this study might provide new insights for the development of drugs for cancer  treatment and/or preventing the spread of cancer cells.

PI_NAMEs: NOUBISSI, FELICITE K (contact)

PROJECT_TERMS: Acceleration;Actins;Adhesions;Antineoplastic Agents;Apoptosis;Apoptotic;Automobile Driving;BAI1 gene;black women;Bone Marrow;Breast;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Treatment;cancer cell;cancer health disparity;cancer heterogeneity;Cancer Model;Cancer Patient;cancer prevention;cancer therapy;Cause of Death;Cell fusion;Cell Separation;Cells;clinically relevant;Communities;defined contribution;Development;Disease Progression;Disparity;Distant Metastasis;drug development;Drug resistance;Event;Exhibits;Forensic Medicine;G-Protein-Coupled Receptors;Genes;Genetic;Genetic Polymorphism;Genomics;Goals;Health Disparities Research;Hematopoietic;Heterogeneity;Hypoxia;In Vitro;in vivo;Incidence;Induction of Apoptosis;insight;Invaded;Knock-out;Knockout Mice;Length;Lesion;Link;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mesenchymal;mesenchymal stromal cell;Metastatic Melanoma;Modification;Molecular;mouse model;Myoblasts;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;novel;novel drug class;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;phosphatidylserine receptor;Population;prevent;Primary Neoplasm;promoter;rac1 GTP-Binding Protein;receptor;Reporting;Research;Resistance;Role;Short Tandem Repeat;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;statistics;stem;Stress;Stromal Cells;Structure;survival disparity;Survival Rate;Time;transcriptomics;Transplantation;triple-negative invasive breast carcinoma;tumor;tumor heterogeneity;tumor microenvironment;United States;White Women;Xenograft procedure

PROJECT_TITLE: Cancer cell fusion; A mechanism driving breast tumor heterogeneity and metastasis


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Lung;Pulmonary Fibrosis;Social Determinants of Health

PHR: Project Narrative:  Pulmonary fibrosis (PF) is a progressive, deadly lung disease and without an effective treatment except lung  transplant. The proposed study aims to explore the molecular mechanisms underlying lung fibrosis associated  with microRNA. The ultimate goat of the study is to identify potentially a novel therapeutic approach for  effective treatment of PF.

PI_NAMEs: PACURARI, MARICICA  (contact)

PROJECT_TERMS: A549;alveolar epithelium;Binding;Bleomycin;cancer type;Carbon nanoparticle;Cell Line;Cells;Characteristics;Complex;Data;Deposition;Development;Diagnosis;Disease;DNA Polymerase II;double walled carbon nanotube;effective therapy;Epithelial Cells;Exposure to;Extracellular Matrix;Feedback;fibrogenesis;fibrotic lung;Fluorescence Resonance Energy Transfer;Genetic Transcription;Goals;Goat;Health;Health Disparities Research;Human;Hydrogen Peroxide;in vivo;indium-bleomycin;insight;Link;loss of function;Luciferases;Lung;Lung Diseases;lung injury;Lung Transplantation;Malignant neoplasm of lung;MAP Kinase Gene;MAPK3 gene;Measures;Mediating;Messenger RNA;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mRNA sequencing;Mus;novel therapeutic intervention;overexpression;Oxidative Stress Pathway;p65;Pathway interactions;Persons;pharmacologic;Plasmids;Play;Production;Progressive Disease;Pulmonary Fibrosis;Reactive Oxygen Species;Regulation;Reporting;response;Risk Factors;RNA;Role;Signal Pathway;Signal Transduction;Silicon Dioxide;Small Interfering RNA;Structure of parenchyma of lung;Testing;Therapeutic;therapeutic miRNA;Thrombospondin 1;toxicant;Transcriptional Regulation;transcriptome sequencing;Transfection;Transforming Growth Factor beta;Untranslated Regions

PROJECT_TITLE: Pulmonary Fibrosis Regulation by miR-1


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Violence Research

PHR: Narrative Involuntary commitment is a legal and health intervention used to mandate treatment for people with behavioral health problems who are thought to be at imminent risk for harming themselves or others. The process often relies upon law enforcement officers to apprehend the person of concern from the community, so that treatment can be initiated. Our proposal will examine the use and consequences of law enforcement mediated involuntary commitment and its possible role in exacerbating or mitigating racial disparities in overdose, self-harm, and justice-involvement.

PI_NAMEs: ROSEN, DAVID L (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;assault;Attitude;behavioral health;behavioral health intervention;Black Populations;Black race;care outcomes;Caring;Cessation of life;Characteristics;Coercion;Communities;County;court;Criminal Justice;Data;Emergency Department evaluation;Emergency department visit;Ethics;experience;Family member;Frequencies;Government;Health;health care availability;health care disparity;Health Personnel;high risk;Incidence;Individual;Injury;Inpatients;insight;interest;International Classification of Disease Codes;Intervention;Interview;Involuntary Commitment;Justice;Knowledge;Law Enforcement;Law Enforcement Officers;Laws;Legal;Length of Stay;Link;Mediating;Medical;Medical Records;men;Modernization;Motivation;Natural Language Processing;Nature;North Carolina;Outcome;Overdose;overdose death;overdose risk;Patients;Perception;Persons;Pharmaceutical Preparations;Police;Procedures;Process;Public Health;public health intervention;Race;racial difference;racial discrimination;racial disparity;racial health disparity;racial population;relative effectiveness;Research;response;Risk;Role;rurality;Safety;Sampling;Self-Injurious Behavior;severe mental illness;sociodemographics;substance use;Time;Training;trend;Trust;Use Effectiveness;Woman

PROJECT_TITLE: Examining racial disparities in fatal overdose, self-harm, and perpetrating assaults following law enforcement-mediated involuntary commitment

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth;Women's Health Research

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Cervical cancer is one of the most preventable cancers and when diagnosed early and appropriately treated, the likelihood of survival is close to 100%. Despite this, urban, underserved minority women in the US have lower rates of follow-up regimens after an abnormal test result compared to White women and this has been linked to the disparities in cervical cancer cases among this population. The proposed study will develop and evaluate a novel, theory-based mHealth intervention available in both English and Spanish consisting of patient- focused text-based barriers counseling and as-needed telephone health coaching thereby increasing long-term follow-up rates among urban, underserved minority women.

PI_NAMEs: HUDSON, SHAWNA V.;MILLER, SUZANNE M (contact);WEN, KUANG-YI

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Address;Adoption;Affect;Appointment;Appointments and Schedules;Attention;Behavior Therapy;Cancer Control;cancer health disparity;cancer risk;Cellular Phone;Cervical;cervical cancer prevention;Clinic;Cognitive;Colposcopy;Communication;contextual factors;Counseling;Databases;Death Rate;Dedications;Diagnosis;Diagnostic tests;disorder risk;Disparity;disparity gap;Dissemination and Implementation;Early Diagnosis;effectiveness evaluation;effectiveness/implementation study;effectiveness/implementation trial;efficacy evaluation;English Language;Ethnic Origin;evidence base;Evidence based intervention;Exploration, Preparation, Implementation, and Sustainment;Feedback;follow-up;Grain;Health;health assessment;Health behavior;health literacy;Health system;Healthcare;Healthcare Systems;Hybrids;implementation framework;implementation intervention;implementation outcomes;information processing;innovation;Intervention;intervention effect;Intervention Studies;Interview;Language;Link;Longterm Follow-up;low health literacy;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical Care Team;member;Methods;mhealth interventions;Minority Women;Modeling;Monitor;National Cancer Institute;novel;operation;Patient Monitoring;Patient Schedules;Patients;Physicians;Population;primary outcome;programs;Protocols documentation;Race;Randomized;Randomized, Controlled Trials;recruit;Regimen;Research;Research Design;Resource-limited setting;Resources;Schedule;screening;secondary outcome;Sequential Multiple Assignment Randomized Trial;Site;social;Spanish;Spanish/English;standard of care;Structure;Surveys;System;Target Populations;Telephone;telephone based;telephone coaching;Test Result;Testing;Text;Text Messaging;theories;Time;trial design;underserved minority;Underserved Population;United States National Institutes of Health;uptake;White Women;Woman

PROJECT_TITLE: Reducing Urban Cervical Cancer Disparities Using a Tailored mHealth Intervention to Enhance Colposcopy Attendance

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Nanotechnology;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: The incidence of lung cancer is disproportionately higher for African American  population. Long-term goal of the project is developing a novel nano-platform with  capability of early diagnosis of lung cancer. This research aligns with the NIMHD’s  vision of “eliminating health disparities”.

PI_NAMEs: RAY, PARESH CHANDRA (contact)

PROJECT_TERMS: Affect;African American population;American Cancer Society;Antibodies;Bacteria;Biological Assay;Blood;Blood Screening;Blood specimen;blood-based biomarker;cancer biomarkers;cancer cell;Cancer cell line;Cancer Detection;cancer diagnosis;Cancer Etiology;Cancer Patient;Carbon;CD81 gene;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;circulating biomarkers;Clinical;clinical application;clinically relevant;Color;CTAG1 gene;Death Rate;design;Detection;detection assay;Development;Devices;Diagnosis;Diagnostic;Disease;disease diagnosis;Disparity;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Epidermal Growth Factor Receptor;Epithelium;ethnic diversity;Ethnic Population;exosome;experimental study;Flow Cytometry;Fluorescence;Genes;Goals;graphene;Health Disparities Research;health disparity;healthy volunteer;Image;Imaging Techniques;improved;Incidence;lung cancer cell;Magnetism;Malignant neoplasm of lung;Malignant Neoplasms;Mediator;Medical center;Mesenchymal;Methods;Mississippi;nanoparticle;nanotechnology platform;National Cancer Institute;National Institute on Minority Health and Health Disparities;Neoplasm Circulating Cells;Neoplasm Metastasis;novel;Outcome;Pathologist;Patients;peripheral blood;Pharmaceutical Preparations;Population;Population Heterogeneity;Process;Proteins;racial diversity;racial population;Reporting;Research;Testing;Time;Tumor Markers;Tumor-Derived;United States;Universities;Viola;Vision;Whole Blood;Work

PROJECT_TITLE: Multifunctional Nanoplatforms-Based Capture and identification of Circulating Tumor Biomarkers for  Early Diagnosis of Lung Cancer


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Vaccine Related

PHR: NARRATIVE Glioblastoma (GBM) is uniformly lethal and is the most common malignant primary brain tumor; current therapy is incapacitating and produces a median overall survival (OS) of less than 2 years. We have published on an innovate method for preconditioning a vaccine site with recall antigens that boost the migration of dendritic cells carrying tumor-specific antigen to the lymph nodes, resulting in increased overall survival of patients with newly diagnosed GBM. Since this publication we have identified the primary driver of this enhanced immunity to be the chemokine CCL3, and we propose to mechanistically examine the role of CCL3 as a novel developmental therapeutic treating brain cancer.

PI_NAMEs: FECCI, PETER ;GUNN, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;anti-tumor immune response;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Blood;Bone Marrow;Brain Neoplasms;Cancer Etiology;CCL3 gene;Cell Count;cell motility;Cellularity;Cessation of life;chemokine;chemotherapy;childhood cancer mortality;Circulation;Clinical;Cytotoxic T-Lymphocytes;Data;dendritic cell vaccination;Dendritic Cell Vaccine;Dendritic Cells;Development;Developmental Therapeutics Program;Dose;Dose Limiting;draining lymph node;early phase clinical trial;efficacy evaluation;Glioblastoma;Glioma;Goals;Heterogeneity;Human;Immune response;Immunity;immunological diversity;Immunosuppression;Immunotherapy;improved;Individual;Inflammation;innovation;lymph nodes;Malignant - descriptor;Malignant neoplasm of brain;Mature T-Lymphocyte;Melanoma;Methods;migration;Modeling;mouse model;Mouse Strains;Mus;Nature;neoplastic cell;neuroimmunology;Newly Diagnosed;Normal tissue morphology;novel;novel anticancer drug;novel therapeutics;Operative Surgical Procedures;patient response;Patients;Peripheral;pre-clinical;preconditioning;Primary Brain Neoplasms;Publications;Publishing;Radiation;recruit;Regimen;Regulation;Renal Carcinoma;response;Role;secondary lymphoid organ;Site;Surveys;T-Cell Activation;T-Lymphocyte;Therapeutic;therapeutic vaccine;Toxic effect;tumor;Tumor Antigens;tumor eradication;Tumor Escape;tumor heterogeneity;tumor progression;Vaccines;young adult

PROJECT_TITLE: Clinical Neuroimmunology of CCL3 in Brain Tumors

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE The proposed research is relevant to public health because it develops novel treatments to overcome resistance in the highly lethal mesothelioma. We will target the mitochondria which both drives tumor grow and blocks tumor cell death which makes mesothelioma resistance to most treatment. This project is relevant to the NIH mission to discover new tumor targets, biomarkers of therapeutic responses, and agents that target the mitochondria.

PI_NAMEs: RIPLEY, ROBERT TAYLOR (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Adjuvant Study;Aftercare;Alternative Therapies;Apoptosis;Apoptotic;arm;Asbestos;BCL2 gene;Biological Markers;Biopsy;cancer cell;Cancer Etiology;Cell Death;Cell Line;Cells;Cessation of life;checkpoint inhibition;checkpoint therapy;chemotherapy;Chemotherapy-Oncologic Procedure;Chest;Cisplatin;Clinical;Clinical Trials;Data;Development;Diagnosis;Disease;effective therapy;efficacy evaluation;efficacy testing;Enzymes;Epigenetic Process;Excision;Exposure to;Family member;FBXW7 gene;FDA approved;feasibility trial;Fiber;fighting;genetic regulatory protein;Goals;Histones;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunocompromised Host;improved;in vivo;Inflammation;Inhalation;inhibitor;insight;ipilimumab;Life Expectancy;Lung;Malignant Neoplasms;Malignant Pleural Mesothelioma;MCL1 gene;Mediating;Mesothelial Cell;Mesothelioma;Metabolic Pathway;metabolomics;Methionine;Methyltransferase;Mission;Mitochondria;Modeling;mouse model;myeloid leukemia cell;Neoadjuvant Therapy;neoplastic cell;Neoplastic Cell Transformation;Nivolumab;novel;Operative Surgical Procedures;Outer Mitochondrial Membrane;Pathway interactions;patient derived xenograft model;patient subsets;Patient-Focused Outcomes;Patients;Pemetrexed;Pharmaceutical Preparations;Pharmacotherapy;Phase;Pleura;Pleural cavity;Predisposition;prevent;primary endpoint;Protein Methylation;protein protein interaction;Protein-Arginine N-Methyltransferase;Proteins;Proteomics;Public Health;Randomized;randomized trial;Recurrence;Research;Resistance;Resistance development;response;safety and feasibility;Sampling;Side;Survival Rate;targeted agent;Testing;Therapeutic;therapeutic target;therapy resistant;transcriptomics;Translating;translational potential;treatment response;treatment strategy;tumor;tumor microenvironment;Ubiquitination;United States National Institutes of Health;Unresectable;Up-Regulation;Work

PROJECT_TITLE: Targeting the Mitochondria to Overcome Resistance to Immune Checkpoint Inhibition in Malignant Pleural Mesothelioma

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Narrative: Urinary stone disease (USD) is on the rise and represents the second most costly urologic condition in the US, with a healthcare cost over $10 billion per year. Despite the growing clinical enthusiasm and rapid development of new technologies in laser lithotripsy (LL), which is the current treatment of choice for surgical management of USD, the fundamental theory about cavitations in LL has been lacking, hindering the efforts to reduce procedure time and improve clinical outcome. In this project, we propose to develop the 3D super- resolution passive cavitation mapping technology for real-time analysis of the cavitation activities during LL, which will provide valuable information on optimizing the LL treatment strategy for USD patients.

PI_NAMEs: LIPKIN, MICHAEL E;YAO, JUNJIE  (contact);ZHONG, PEI

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;Ablation;Acoustics;Address;Adverse effects;Characteristics;climate change;Clinical;clinically relevant;Correlation Studies;cost;Coupled;deep learning;Detection;Development;Disease;Dust;Environmental Risk Factor;Epidemic;experience;Family suidae;Feedback;Fiber;Fluoroscopy;Frequencies;Goals;Health Care Costs;Healthcare Fees;Holmium;Image;image guided;Imaging technology;Implant;improved;In Vitro;in vivo Model;Individual;Investigation;Kidney;Knowledge;Laser Lithotripsy;Lasers;Light;Lithotripsy;Magnetic Resonance Imaging;Maps;Metabolic syndrome;meter;Methods;new technology;Obesity;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Physics;Physiologic pulse;Pilot Projects;Play;porcine model;Prevalence;Procedures;Radiation;Radioactive;real time monitoring;Research;Resolution;Retrieval;Risk;Risk Factors;Role;Shock;Skin;Stress;Surgical Management;System;Technology;Testing;theories;Therapeutic;Three-dimensional analysis;Time;tool;transmission process;treatment choice;Treatment Effectiveness;treatment strategy;ultra high resolution;Ultrasonography;United States;Ureteroscopy;Urinary Calculi;urologic;Urologist;Work;X-Ray Computed Tomography

PROJECT_TITLE: 3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Obesity;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Our project aims to transform early detection and screening methods for Pancreatic Ductal Adenocarcinoma (PDAC) by developing a 'fair' fusion model, “PRECISE” (PancREas Cancer multImodal riSk prEdiction), which integrates imaging and non-imaging biomarkers from multisite cohorts. The model leverages deep learning and adversarial debiasing techniques to incorporate diverse clinical data, enabling more effective risk predictions, especially for minority subgroups. Through a scalable automated risk stratification, we aspire to provide opportunistic screening to patients undergoing routine abdominopelvic CT exams, aiming for an early and accurate prediction of future PDAC risk.

PI_NAMEs: BANERJEE, IMON  (contact);PENG, YIFAN

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: abdominal CT;Accounting;Age;Algorithms;Anxiety;Arizona;Assessment tool;automated segmentation;Biological Markers;Body Composition;Cancer Etiology;Cessation of life;chemoradiation;Clinic;clinical biomarkers;Clinical Data;clinical risk;cohort;Computerized Medical Record;cost;Data;deep learning;deep learning model;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Distress;Early Diagnosis;Early Intervention;early screening;Early treatment;Eligibility Determination;Encapsulated;Engineering;Ensure;Excision;federated learning;Florida;Future;Gender;General Population;geographic disparity;Geographic Locations;Goals;Graph;graph neural network;high risk population;Image;imaging biomarker;imaging Segmentation;improved;Incidence;Individual;Malignant neoplasm of abdomen;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic syndrome;Methods;Midwestern United States;Minority;Modeling;multimodal data;multimodal fusion;multimodality;Nature;Neoplasm Metastasis;Neural Network Simulation;novel;Obesity;Operative Surgical Procedures;Outcome;Pancreas;Pancreatic Ductal Adenocarcinoma;patient screening;patient subsets;Patient-Focused Outcomes;Patients;Performance;predictive tools;premalignant;prognostic;prognostic model;prognostic performance;prognostic value;prospective;Race;radiologist;radiomics;recruit;Resistance;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Scanning;screening;Screening procedure;Semantics;Site;Smoking;Smoking Status;social health determinants;Socioeconomic Factors;socioeconomics;Subgroup;Survival Rate;Techniques;Testing;Time;Training;tumor;Tumor Biology;United States;Universities;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Multimodal AI Fusion Model for Early Detection for Pancreatic Cancer

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: STANFORD

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative One in 26 people in the United States develops epilepsy, temporal lobe epilepsy is one of the most common types, and current treatments fail for approximately 1/3rd of patients. The proposed project would test whether the loss of a specific type of inhibitory brain cell causes seizures in patients. Knowledge of causes of seizures will lead to better treatments.

PI_NAMEs: BUCKMASTER, PAUL S. (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Animal Model;Axon;biocytin;Blocking Antibodies;Brain;brain cell;Cells;Characteristics;Compensation;Data;dentate gyrus;Dorsal;effective therapy;Electroencephalography;Epilepsy;Epileptogenesis;Frequencies;Goals;granule cell;Hippocampus;Human;immunocytochemistry;Infusion procedures;Injury;Interneurons;Knowledge;Label;Measures;Methods;Molecular;Monitor;mouse model;neuronal cell body;neuropathology;Nitric Oxide Synthase;Osmosis;Outcome;Output;Pathologic;Patients;Persons;Pilocarpine;postsynaptic;prevent;Pump;Rattus;Sea Lions;Seizures;Slice;Synapses;Telemetry;Temporal Lobe;Temporal Lobe Epilepsy;Testing;United States;Whole-Cell Recordings

PROJECT_TITLE: Temporal lobe epileptogenesis

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Nutrition;Prevention;Serious Mental Illness;Social Determinants of Health

ORG_CITY: HERSTON

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: QUEENSLAND INSTITUTE OF MEDICAL RESEARCH

PHR: PROJECT NARRATIVE / RELEVANCE The Eating Disorders Genetics Initiative 2 (EDGI2) unites existing and exceptionally productive and collaborative sites globally to advance genetic discovery across all eating disorders (anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder). We will apply both novel and established methods to optimize discovery in our diverse and severely ill sample, culminating in a clinical translation summit. Our goal is to identify biologically, clinically, culturally, and therapeutically meaningful and actionable insights and rapidly transition the field from discovery to clinical translation.

PI_NAMEs: JORDAN, JENNIFER ;KENNEDY, MARTIN ALEXANDER;MAGUIRE, SARAH ;MARTIN, NICHOLAS G (contact)

PROJECT_TERMS: Adipose tissue;Alleles;Anorexia Nervosa;Atlases;Australia;avoidant restrictive food intake disorder;Behavior;Binge eating disorder;Bioinformatics;Biology;Body mass index;Brain;brain cell;Bulimia;Businesses;cell type;Clinical;Clinical Research;clinical translation;cohort;Collection;Communities;community partners;comorbidity;Data;Denmark;Diagnosis;Diagnostic;Dimensions;Disease;disorder prevention;DNA;Eating Disorders;Enrollment;Environmental Exposure;Environmental Risk Factor;Etiology;evidence base;Gene Expression;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Risk;genome wide association study;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Grouping;Heritability;Heterogeneity;Human Resources;Individual;innovation;insight;Intervention;Knowledge;Liver;marginalization;marginalized community;Mendelian randomization;Mental Depression;Mental disorders;Meta-Analysis;Metabolic;Metabolic Diseases;Methods;Mexico;Minority;minority communities;Minority Enrollment;Modeling;Molecular;molecular subtypes;Muscle;Nervous System Disorder;Neurosciences;New Zealand;novel;Participant;Pathway interactions;patient stratification;patient subsets;Pattern;Phase;Phenotype;polygenic risk score;Production;Productivity;psychiatric genomics;Psychiatry;rare variant;recruit;Regional Anatomy;resilience factor;Resources;response;risk prediction;Role;Salivary;Sample Size;Sampling;Science;Severities;sex;single nucleus RNA-sequencing;Site;social media;Stress;Stressful Event;Subcellular Anatomy;Sweden;symposium;Symptoms;Taxonomy;Therapeutic;therapy development;Thinking;Tissues;trait;Underrepresented Populations;Variant;Weight Gain;working group

PROJECT_TITLE: 2/3 Eating Disorders Genetics Initiative 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-D (65)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Rehabilitation;Social Determinants of Health

ORG_DEPT: NUTRITION

PHR: PUBLIC HEALTH RELEVANCE The burden of cognitive dementias has rapidly increased, estimated to affect 152 million people by 2050. Despite this projection, there has been limited progress in understanding how best to prevent, treat, and manage dementias. The objective of the proposed study is to identify trajectories of key risk factors and their combinations that predict or protect against early and severe cognitive decline and to increase understanding of the modifiable social, behavioral and environmental factors that prevent or reduce the burden of age-related dementias.

PI_NAMEs: ADAIR, LINDA S;POPKIN, BARRY M (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Affect;Age;age related;Age Years;aged;Aging;aging population;aging process;Alcohol consumption;Alzheimer's Disease;Anthropometry;Attention;Behavior;Behavioral;Biological;Biological Factors;Biological Markers;Blood;Blood Pressure;cardiometabolism;China;Chinese;Cognitive;cognitive function;Collection;Communities;Complex;cost;cytokine;Data;Data Collection;Data Element;Data Files;data repository;Data Set;Dementia;dementia burden;dietary;Dietary intake;Disease;Early identification;Economics;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;evidence base;executive function;experience;Exposure to;Fasting;follow-up;Fostering;Funding;Generations;genome wide association study;Geography;Health;Health behavior;Health care facility;Health Surveys;healthy aging;Hearing;Household;Humidity;Impaired cognition;improved;Individual;inflammatory marker;insight;instrumental activity of daily living;Intergenerational transfer;Laboratories;Left;Life Cycle Stages;Life Expectancy;Life Style;Link;Location;Longitudinal Surveys;Longterm Follow-up;Measures;Memory;Mental Health;metabolome;microbiome;middle age;migration;Modernization;modifiable lifestyle factors;Monitor;novel;novel marker;nutrition;Nutrition Surveys;older adult;Older Population;Participant;pathogenic bacteria;pathogenic virus;Personal Satisfaction;Persons;Physical activity;physical conditioning;Physical Function;Pilot Projects;Population;Predisposition;preservation;prevent;Prevention;protective factors;public health relevance;Quality of life;Research;Research Institute;Risk Factors;Sampling;Schools;Series;Sleep;social;Social Change;social factors;sociodemographics;Statistical Models;stool sample;Stress;Structure of nail of toe;Supermarket;Surveys;Testing;Time;time use;Tobacco use;Tooth Loss;trend;United States National Institutes of Health;Urbanization;Viral Markers;Vision;web site;Work

PROJECT_TITLE: Monitoring Social Change: Dynamics Of Aging And Cognitive Function

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Behavioral, psychological, and social factors contribute to the development of cardiovascular diseases and their unequal distribution across populations. To address the public health burden of cardiovascular diseases, the Strategic Vision of the National Heart, Lung, and Blood Institute has underscored the need to train a diverse workforce of translational scientists who conduct rigorous, interdisciplinary research on the behavioral, psychological, and social factors in cardiovascular disease risk and resilience. Our T32 program has been dedicated to addressing this need for nearly 40 years by providing state-of-the-art training in cardiovascular behavioral medicine research.

PI_NAMEs: GIANAROS, PETER J;THURSTON, REBECCA C (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Behavioral Medicine;Cardiovascular system;Research Training

PROJECT_TITLE: Cardiovascular Behavioral Medicine Research Training

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The statistical and agent-based model tools developed through this project in urban Kenya will be widely applicable to studying multi-pathogen infectious disease transmission dynamics in low to middle income nations, and will address global needs for evidence to prioritize urban development interventions.

PI_NAMEs: BAKER, KELLY K;SEWELL, DANIEL  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Accounting;Affect;Animals;Area;attributable risk;Behavior;Behavioral;Biological Assay;burden of illness;Caregivers;Cattle;Characteristics;Child;Communicable Diseases;Communities;Complex;Computer Models;Computer software;Computing Methodologies;Country;Data;Defecation;Demographer;design;Detection;Developing Countries;Development;Diarrhea;Diffusion;Disease;Disease Pathway;disease transmission;Domestic Animals;dynamic system;Economic Development;Economics;Ecosystem;effective intervention;Enteral;enteric infection;enteric pathogen;Environment;Epidemiologist;Evolution;experimental study;exposure pathway;Exposure to;Failure;Feces;Floor;Frequencies;gastrointestinal;Geography;Household;Human;improved;Incidence;Income;Individual;Infant;Infection;infection risk;Ingestion;Intervention;Joints;Kenya;large datasets;Latrine;Lead;Long-Term Effects;Low income;Mathematics;Measures;Methods;microbial;microbial community;Microbiology;Milk;model design;Modeling;Morbidity - disease rate;mortality;Movement;multi-scale modeling;Neighborhoods;open source;pathogen;Pathogenicity;Pathway interactions;Pattern;pediatrician;Policies;Pollution;Population Attributable Risks;Positioning Attribute;predictive modeling;Prevalence;prevent;Process;Research;Research Personnel;Risk;Sanitation;Scientist;Seasons;simulation environment;Site;social;Social Development;sociologist;Source;spatiotemporal;Statistical Methods;Statistical Models;stool sample;Structure;Surveys;System;Taxonomy;Testing;therapy development;tool;Training;transmission process;urban area;Urban Community;Urban Developments;urban setting;Urbanization;Viral;virtual laboratory;wasting;Water;Work

PROJECT_TITLE: Statistical and agent-based modeling of complex microbial systems: a means for..

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(55)R]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Heart Disease;Nanotechnology;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This proposal will investigate injury to the brain during heart surgery using subcellular, cellular, and large animal models. Our laboratory has extensive experience with these mechanisms and models and has demonstrated some of the mechanistic pathways that underlie this brain injury. Additional pathways of injury remain unknown. By improving the knowledge of these mechanisms of injury and testing them in models that can be translated to human trials, this proposal has the potential to help hundreds of thousands of patients who suffer from cardiovascular disease.

PI_NAMEs: LAWTON, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: FENTON, KATHLEEN NELLE

PROJECT_TERMS: Adenosine Triphosphate;Animal Model;antagonist;Aorta;Apoptosis;arterial spin labeling;Attenuated;Biochemistry;Biological Markers;blood-brain barrier crossing;Brain;Brain imaging;Brain Injuries;Calcium;canine model;Cardiac;Cardiac Myocytes;Cardiac Surgery procedures;Cardiovascular Diseases;Cell Death;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;Clinical;clinical practice;Complex;Dendrimers;Diazoxide;Dose Limiting;Drug Delivery Systems;Effectiveness;effectiveness evaluation;excitotoxicity;experience;experimental study;Funding;glial activation;Glutamates;Goals;Grant;Heart;Hippocampus;Histopathology;Human;improved;improved outcome;Injury;Ischemia;Ischemic Brain Injury;ischemic injury;Ischemic Preconditioning;Ketamine;Knowledge;Laboratories;Magnetic Resonance Imaging;Mediator;men;Microglia;Mitochondria;mitochondrial dysfunction;MK801;Modality;Modeling;Molecular;multidisciplinary;Myocardial Ischemia;Myocardium;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;nanodevice;nanomedicine;nanoparticle;natural hypothermia;Necrosis;Nervous System Trauma;neurobehavioral;neurochemistry;neuroinflammation;Neurologist;neuron loss;Neuronal Injury;Neurons;neuroprotection;Neuroprotective Agents;Neurosurgeon;neurotransmitter release;novel;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Potassium Channel;Potassium Phosphate;pre-clinical;prevent;protective effect;randomized trial;Receptor Activation;Serum;side effect;Stress;Surgeon;targeted delivery;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Uses;Time;Tissues;Transesophageal Echocardiography;Translating;translational model;United States;Woman;Work

PROJECT_TITLE: Excitotoxicity and Mitochondrial Dysfunction in Circulatory Arrest- Brain Injury

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative This grant proposal is to understand genetic and epigenetic regulations of hemangiogenesis, blood and blood vessel formation, in the developing mouse embryo. Notably, we will investigate if expression levels of Etv2, an essential ETS transcription factor for hematopoietic and endothelial cell development, dictate hemangiogenic versus smooth muscle lineage outcome. We will also delineate ETV2 mediated enhancer switching mechanisms of Flk1 expression and the interplay between ETV2 and the BAF155, a subunit of the mammalian SWI/SNF chromatin-remodeling BAF (BRG1/BRM associated factor) complex, in chromatin remodeling of the ETV2 target gene loci. This study's outcome is highly relevant to basic research and regenerative medicine of the hematopoietic and cardiovascular systems.

PI_NAMEs: CHOI, KYUNGHEE  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acetylation;Address;Applications Grants;ATAC-seq;Bar Codes;Basic Science;Blood;Blood Cells;blood vessel development;Blood Vessels;Cardiac;Cardiovascular system;Cell Differentiation process;Cell Lineage;Cell Reprogramming;cell type;Cells;ChIP-seq;Chromatin;chromatin remodeling;cofactor;Complex;Data;Defect;demethylation;Development;differentiation in vitro;DNA;dosage;Embryo;embryo cell;Embryonic Development;embryonic stem cell;Endothelial Cells;Enhancers;Epigenetic Process;epigenetic regulation;Event;Feedback;GATA3 gene;Generations;Genes;Genetic;Genome Mappings;genome-wide;genomic locus;Goals;Growth;Hematopoietic;Hematopoietic System;Heterogeneity;Human;Impairment;in vivo;insight;Investigation;KDR gene;Knock-out;Knowledge;Maps;Mediating;Mesoderm;Modeling;Molecular;Mus;Outcome;Outcome Study;Output;overexpression;Pathologic Processes;Pathway interactions;Play;Pluripotent Stem Cells;Population;Process;programs;promoter;recruit;Regenerative Medicine;Regulation;Role;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;SMARCA4 gene;SMARCC1 gene;Smooth Muscle;Smooth Muscle Myocytes;Somatic Cell;Specific qualifier value;stem cells;System;Testing;transcription factor;transcriptome;Transgenic Organisms;translational potential;Vascular Endothelial Growth Factors;Vascular System;Yolk Sac;Zebrafish

PROJECT_TITLE: HEMANGIOBLAST DEVELOPMENT AND REGULATION

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Nanotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: CHEMISTRY

PHR: Project narrative: We will investigate how membrane curvature regulates biochemical signals that are transmitted through the cell-matrix interface by using nanotechnology-based precision engineering. The knowledge gained will help to guide the design of biomaterials and biodevices for better integration with cells. We will also develop nanoscale electrodes to accurately record intracellular action potentials, which impact our understanding of membrane resealing in heart cells, as well as impact biotechnology.

PI_NAMEs: CUI, BIANXIAO  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Action Potentials;Affect;Biochemical;Biocompatible Materials;Biological;biological systems;Biotechnology;Cardiac Myocytes;Cell Communication;Cell Physiology;Cells;Classification;design;Development;Electrodes;Electrophysiology (science);Engineering;Environment;Extracellular Matrix;Future;Generations;Goals;heart cell;In Vitro;Intervention;Knowledge;mechanical force;Mechanics;Membrane;Molecular;Monitor;nanoelectrodes;nanoscale;Nanotechnology;Nanotopography;parent grant;patch clamp;Process;Proteins;Role;Rupture;seal;sensor;Signal Transduction;stem cells;Surface;tool;transmission process

PROJECT_TITLE: Nanoscale probes for sensing molecular functions in live cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Senescent cells are growth arrested cells that are highly associated with aging and chronic diseases and could be targeted to slow the aging process. The transcriptomic signatures of senescent cells are not well defined which has implications for designing treatments to treat aging related diseases. This proposal will leverage single nucleus RNA-sequencing techniques in order to understand the molecular markers that define senescent cells and may lead to the development of more efficacious therapies to target senescent cells.

PI_NAMEs: COHN, RACHEL  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adipose tissue;Affect;age related changes;age-related disease;aged;Aging;aging mechanism;aging process;aging related disease;Biological Models;career;Cell Aging;cell growth;cell type;Cells;Chronic Disease;Clinical;Communication;Computer Analysis;cost;cytokine;Dasatinib;Data;Data Set;design;Development;Disease;Dissociation;Drug Design;efficacious treatment;Environment;Fatty acid glycerol esters;Fellowship;Funding;Future;Gene Expression Profiling;Genetic;Genetic Markers;Goals;Growth;Health;Heterogeneity;Human;human old age (65+);human tissue;improved;In Vitro;in vivo;Individual;Inflammatory;Institution;Intervention;Investigation;Knowledge;late life;Learning;life span;Mentorship;Methods;Modeling;molecular marker;mouse model;novel;novel marker;Nuclear;Nuclear RNA;old mice;oncoprotein p21;Outcome;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physicians;Population;pre-clinical;precision medicine;Protocols documentation;Quality of life;Quercetin;Reporting;Research;Risk Factors;RLK5-associated protein phosphatase;Scientist;senescence;senescent cell;senolytics;side effect;single nucleus RNA-sequencing;skills;Techniques;The Jackson Laboratory;therapy design;tissue mapping;Tissue-Specific Gene Expression;Tissues;Training;training opportunity;transcriptome;transcriptome sequencing;transcriptomics;Transgenic Mice;Validation;Work;Writing

PROJECT_TITLE: Investigating Cellular Senescence at the Single Cell Level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);HIV/AIDS;Mental Health;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE People living with HIV (PLWH) have a high burden of pain, and most commonly experience neuropathic pain, for which there are few treatments. Medical cannabis has emerged as a possible treatment even though there is a dearth of information about its mechanism of analgesia and potential adverse events. This proposal will shed light on these gaps in our knowledge by examining how medical cannabis affects pain, inflammation, and adverse events in PLWH with chronic pain.

PI_NAMEs: SLAWEK, DEEPIKA  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Absence of pain sensation;Adherence;Adverse event;Affect;Alternative Therapies;Anti-Inflammatory Agents;Anti-Retroviral Agents;Anxiety;arm;Blood specimen;Cannabidiol;Cannabis;capsule;Caring;Certification;chronic pain;chronic pain management;Complex;cytokine;Data;Data Sources;depressive symptoms;design;disability;Disease;Dose;Etiology;experience;Failure;federal policy;follow-up;Functional impairment;Gel;Goals;Growth;Health;high risk;HIV;HIV Infections;improved;Inflammation;Inflammatory;innovation;interest;Interleukin-10;Interleukin-4;Interleukin-6;Investigation;K-Series Research Career Programs;Knowledge;Legal;Link;marijuana use;Measurable;Mediation;Medical;medical examination;Medical Marijuana;Mental Depression;Mentors;Mentorship;Modality;multidisciplinary;New York;novel therapeutics;Oils;Opioid;Outcome;Pain;Pain management;pain reduction;painful neuropathy;Participant;patient oriented;Patient Self-Report;Persons;Pharmacy facility;Placebos;Policy Making;primary outcome;psychological symptom;Psychoses;psychotic symptoms;public health relevance;Qualifying;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Records;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Risk;secondary outcome;Severities;skills;systemic inflammatory response;Telephone;Testing;Tetrahydrocannabinol;Time;Titrations;Training;trial design;United States;Visit

PROJECT_TITLE: The impact of medical cannabis on pain and inflammation in people living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative  The research supported by this award will develop new computational methods and tools for drug discovery so that novel therapeutics can be discovered more quickly and with less expense. The de- veloped methods will be evaluated prospectively in drug discovery projects of high relevance to human health. The resources developed will be readily accessible through open-access web sites and open-source software.

PI_NAMEs: KOES, DAVID RYAN (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 3-Dimensional;Acceleration;Actins;Address;antiangiogenesis therapy;Autoimmune Diseases;Award;Binding;Biological Assay;candidate identification;Chemicals;Code;Computer software;computerized tools;Computing Methodologies;deep learning;deep neural network;Development;Diabetic Retinopathy;Disease;Docking;Drug Design;drug discovery;Evaluation;Generations;generative models;Goals;Health;Human;improved;inhibitor;lead candidate;lead optimization;Learning;Libraries;Ligands;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Structure;Molecular Target;Neural Network Simulation;novel;novel therapeutics;open source;open source tool;Pharmaceutical Preparations;Physiology;Process;Productivity;profilin;Property;prospective;Proteins;Pythons;Research;research clinical testing;Research Support;Resources;Sampling;screening;small molecule;Structure;tool;Training;Update;user-friendly;web app;web site;Work

PROJECT_TITLE: New Methods and Tools for Computational Drug Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative – Overall Defining genes and gene networks associated with abusive alcohol use can lead to better understanding of the disease and potentially provide new diagnostics or treatments. The VCU Alcohol Research Center provides a novel and highly significant cross-species genetic, behavioral and genomic approach that promises to contribute broadly to the alcohol research field and the public health.

PI_NAMEs: MILES, MICHAEL F (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Affect;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol research;alcohol response;alcohol use disorder;Alcoholism;Alcohols;analysis pipeline;Animal Model;Area;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Brain;Caenorhabditis elegans;Candidate Disease Gene;candidate validation;Communities;comorbidity;Consumption;Cre-LoxP;CRISPR/Cas technology;Data;data sharing;Dependence;design;Development;Disease;DNA Microarray Chip;Drosophila genus;Environmental Risk Factor;Ethanol;Ethanol Metabolism;Etiology;Event;exome sequencing;Expression Profiling;fly;Funding;gene discovery;Gene Expression;gene network;Genes;Genetic;genetic approach;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;Genetic Vectors;genome wide association study;genome-wide;genome-wide analysis;Genomic approach;genomic data;Genomics;Grant;Human;Human Genetics;human model;Individual;innovation;interest;Intervention;Invertebrates;Investigation;Lead;Measures;Meta-Analysis;model organism;Modernization;Molecular;Mus;next generation sequencing;novel;novel diagnostics;overexpression;Pattern;Phase;Phenotype;Pilot Projects;Positioning Attribute;Predisposition;Prevention;programs;Public Health;Rattus;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;Risk;risk variant;RNA Interference;Rodent;Role;Sampling;Sampling Studies;Scheme;Statistical Data Interpretation;Statistical Methods;Structure;Substance abuse problem;success;Sum;Testing;Therapeutic;trait;transcriptome sequencing;Validation;validation studies;Variant;Viral Vector;Work

PROJECT_TITLE: Cross-species investigation of gene networks for ethanol-related behaviors