ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Improving public health requires a broad range of scientists doing health related research. Physician-scientists are uniquely qualified to do high quality research leading to breakthroughs in diagnosis, prevention, and treatment of disease. Our MD/PhD training program equips our students with strong backgrounds in research and medicine, providing the best of the next generation of physician scientists.

PI_NAMEs: JACOBY, DAVID B (contact);LEWINSOHN, DAVID M.

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TITLE: Medical Scientist Training Program of Oregon Health & Science University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: HS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Lung cancer is the second most commonly diagnosed cancer in the United States, and it is the leading cause of cancer-related deaths among both men and women. A screening test known as low-dose computed tomography can detect lung cancer early and reduce lung cancer deaths among patients with a history of heavy smoking, but this test requires patients and their physicians to carefully consider potential benefits and harms that differ according to each patient’s individual risk profile, and less than 5% of eligible patients receive the screening every year. This project will address this urgent need by widely sharing patient-centered tools that analyze patients’ electronic health records and enable patients and their physicians to review individually- tailored information on the potential benefits and harms of lung cancer screening, so that patients and their physicians can make informed, patient-centered decisions regarding this potentially life-saving test.

PI_NAMEs: KAWAMOTO, KENSAKU  (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Engaging patients to enable interoperable lung cancer decision support at scale

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Genetics;Human Genome;Liver Disease;Microbiome;Natural Products;Nutrition;Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Compelling observational data indicate the benefit of coffee for improved survivorship of colorectal cancer. Coffee contains hundreds of bioactive compounds that are degraded and modified by the gut microbiota and endogenous enzymes to generate new metabolites that can reduce inflammation, modulate metabolism, improve fatty liver and liver fibrosis, and inhibit tumor growth and invasion, thereby reducing cancer recurrence and liver metastasis. Understanding the mechanistic effect of coffee on colorectal cancer survival through modulation of the gut microbiome and liver function will illuminate significant insights into the role of natural products in metabolic regulation and cancer progression and launch novel research into cancer prevention through diet- and gut microbiota-targeted therapeutics.

PI_NAMEs: SONG, MINGYANG  (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Address;Adjuvant;Adult;Aging;American;anti-cancer;Antioxidants;Bacteria;Beverages;Bile Acids;biobank;Biological Markers;Biological Products;Caffeine;cancer prevention;Cancer Prognosis;cancer recurrence;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Cessation of life;chemotherapy;Chlorogenic Acid;Choline;Clinical Data;Clinical Research;Coffee;cohort;colon cancer patients;Colorectal Cancer;colorectal cancer risk;Complex Mixtures;Consumption;Data;Development;Diet;Diet Modification;dietary;Dietary Intervention;Encapsulated;Enzymes;Epidemiology;Escherichia coli;Etiology;Eubacterium;experience;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;fecal metabolome;fecal microbiome;Fibrosis;Freeze Drying;Fusobacterium nucleatum;Genes;Goals;gut microbiome;gut microbiota;Hepatology;improved;indexing;Inflammation;insight;Intake;Intervention;Knowledge;Link;Liver;Liver Fibrosis;liver function;Magnetic Resonance Spectroscopy;Mediating;Metabolic;Metabolism;metabolome;metabolomics;Metastatic Neoplasm to the Liver;Microbe;microbial;microbial signature;microbiome;mortality;multidisciplinary;multiple omics;Natural Products;novel;novel therapeutics;nutrition;Nutritional Study;Oncology;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;Placebos;Plasma;polyphenol;precision nutrition;prognostic;prospective;Prospective cohort;Protons;randomized placebo controlled trial;Randomized, Controlled Trials;Recommendation;Recurrence;Regulation;Research;Research Personnel;Risk;Risk Reduction;Role;screening;secondary metabolite;stool sample;Strategic Planning;survivorship;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Tumor Cell Invasion;tumor DNA;tumor growth;tumor progression;ultrasound;United States National Institutes of Health;Volatile Fatty Acids;Work

PROJECT_TITLE: Coffee and metabolites modulating the gut microbiome for improved colorectal cancer survival

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to public health because the development of new synthetic methods for [2+2] cycloadditions is expected to ultimately enable efficient access to human medicines and biologically active natural products relying on catalytic transformations and inexpensive reagents. The project is relevant to the part of NIH’s mission that includes the development of fundamental knowledge which will help improve and ultimately protect human health.

PI_NAMEs: SCHINDLER, CORINNA STEFANIE (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acids;Alkenes;Alkynes;Area;azetidine;biological research;Catalysis;Characteristics;Chemicals;Chemistry;Complex;Cyclization;cycloaddition;Development;drug development;drug discovery;Drug Kinetics;Energy Transfer;Exhibits;functional group;Genomics;Health;high throughput screening;Human;Imines;improved;Investigation;Knowledge;Label;Lead;Libraries;Mediating;Medicine;member;Methods;Michigan;Mission;Modification;Molecular;Natural Products;novel strategies;novel therapeutics;nucleobase;oxetane;Pathway interactions;Pharmaceutical Chemistry;Pharmacologic Substance;programs;Property;Protocols documentation;Public Health;Reaction;Reagent;Research;RNA;scaffold;Structure;three dimensional structure;tool;Toxic effect;Triplet Multiple Birth;triplet state;Ultraviolet Rays;United States National Institutes of Health;Universities;Variant;Visible Radiation

PROJECT_TITLE: Visible Light-Enabled Synthesis of Heterocycles through Energy Transfer

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: SEELEY, WILLIAM W (contact)

PROJECT_TERMS: Autopsy;Binding;Biochemical;Biological Assay;Biological Markers;Biology;Blood;brain tissue;candidate marker;cerebral atrophy;Clinical;Clinical Trials;Data;derepression;Development;Diagnosis;Diagnostic;digital pathology;Disease;Disease Progression;DNA Transposable Elements;Drug Targeting;Emotions;Enrollment;Event;Exons;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Gene Expression;Genes;Genomic Instability;Goals;Histologic;Image;Immunoassay;insight;Knowledge;Laboratories;Lead;lead candidate;Light;Link;loss of function;Magnetic Resonance Imaging;Measures;Methods;Mobile Genetic Elements;Molecular;Molecular Diagnostic Testing;Molecular Disease;Monitor;Nerve Degeneration;neurofilament;neuroimaging;neuron loss;Neurons;novel;Nuclear;Participant;Pathologic;Pathology;Pathway interactions;Patients;Phase;Plasma;protein expression;protein TDP-43;Proteins;Proteomics;recruit;Repression;Resources;RNA Splicing;Running;Sampling;Severities;Signal Transduction;Stratification;tau Proteins;Testing;Tissues;tool;Toxic effect;transcriptomics;Validation;Work

PROJECT_TITLE: TDP-43 Loss-of-Function: Biology to Biomarkers


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE How layers of cells communicate with each other across hollow voids remains poorly understood, but is relevant to a wide variety of biological phenomena. To illuminate this 'fourth dimension' of tissue biology, we will generate a new type of microscope that allows us to bring sheets of cells closer together or farther apart and measure the strength of their physical connections. We will apply this new technology to determine the role of static electricity when cell sheets are brought into close range interactions, and the role of antenna-like projections called cilia in longer range interactions, as major examples of this nascent field.

PI_NAMEs: FU, HONGXIA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Ablation;Adhesives;Affect;Antibodies;Apical;Architecture;Area;Atomic Force Microscopy;Biological Phenomena;Biology;biophysical tools;Biophysics;Blood Vessels;Cell Adhesion;Cell Communication;cell dimension;Cell Line;Cell surface;Cells;Charge;Chemicals;Cilia;Data;design;Devices;Dimensions;Duct (organ) structure;Electrostatics;Exhibits;experience;Future;Gene Expression Profile;Genetic Engineering;Geometry;Goals;in vivo;innovation;Investigation;Knock-out;Literature;Measures;Membrane Glycoproteins;meter;Methodology;Methods;Microfluidics;Microscope;Modeling;Monitor;Mutation;new technology;novel;Organ;Organelles;Perfusion;Physiological;Physiology;podocalyxin;Positioning Attribute;Property;Resistance;response;Role;sensor;Sensory;sialomucins;Side;Signal Pathway;Signal Transduction;Speed;Static Electricity;Structure;Surface;Testing;therapeutic development;Tissue-Specific Gene Expression;Tissues;Trees;Tube

PROJECT_TITLE: Unveiling Functional Roles of Apical Surface Interactions Between Opposing Cell Layers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-L(55)R]


ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: In this study, we will adapt and implement a digital mental health intervention within the care coordination service of a large healthcare system. The intervention will improve access to and coordination of evidence- based mental health services for adults being served in care coordination. Data gathered throughout this project will be used to develop an implementation guide, capable of being used by other for healthcare systems as they expand their mental health service offerings to provide holistic support for patients.

PI_NAMEs: GRAHAM, ANDREA KASS (contact)

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

PROJECT_TITLE: Implementation of Digital Mental Health Tools in Ambulatory Care Coordination


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Palliative Care;Rare Diseases

PI_NAMEs: MERRILEES, JENNIFER  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Alzheimer's Disease;Attitude;Behavioral;Caregiver Burden;caregiver functioning;caregiver stress;Caregivers;Clinical Trials;Compensation;Complex;Data;Decision Making;Dementia;Dementia caregivers;Diagnosis;Disease;Disease Progression;Emotional;emotional functioning;Emotions;Ethnic Origin;Face;Family;Friends;Frontotemporal Dementia;functional decline;Future;Genes;Genetic;Health;Home;Image;improved;Individual;Individual Differences;informal caregiver;informant;Laboratories;Link;longitudinal design;Measures;Mediating;Mediator;Monitor;novel therapeutics;Outcome;Participant;Pattern;Personal Satisfaction;Persons;Physiological;Play;Quality of Care;recruit;Regulation;Research;resilience factor;Resources;Risk;Risk Assessment;Role;sex;Socioeconomic Status;Source;System;Testing;Therapeutic;therapy design;Time;treatment adherence;Treatment Efficacy;Work

PROJECT_TITLE: Caregiver Health and Attitudes in the Era of Therapeutic Discovery


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Current Cardiac MRI (CMR) is limited in many aspects, which prevent CMR from achieving its full potential. The current proposal builds on our recent success in developing a new paradigm of CMR for pediatric congenital heart disease, which has changed how CMR is practiced in pediatric congenital heart disease. We propose accelerated imaging techniques and patient surgical outcome prediction tools to boost the value of CMR in managing children with congenital heart disease.

PI_NAMEs: CHRISTODOULOU, ANTHONY G;FINN, JOHN PAUL (contact);NGUYEN, KIM-LIEN T

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3D Print;4D MRI;Acceleration;Achievement;Adopted;Adult;Affect;anatomic imaging;Anatomy;Anesthesia procedures;Angiography;Bayesian Modeling;Biological;Birth;Blood flow;Blood Vessels;Breathing;Cardiac;cardiac magnetic resonance imaging;Cardiovascular system;Catheterization;Child;Child health care;Childhood;Clinical;clinical translation;Collaborations;Common Ventricle;Compensation;Complement;Complex;computer framework;Computer Models;Congenital Abnormality;congenital heart abnormality;Contrast Media;Data;Data Pooling;Data Set;deep neural network;Defect;Development;Diagnostic;Diagnostic Imaging;diagnostic value;Echocardiography;Elements;Engineering;Evaluation;experience;Experimental Models;Feedback;ferumoxytol;Funding;Gadolinium;General Anesthesia;Goals;Heart;hemodynamics;Image;image reconstruction;imaging modality;Imaging Techniques;Imaging technology;improved;In Vitro;in vivo;indexing;Infrastructure;Institution;Intratracheal Intubation;Intubation;Ionizing radiation;Left;Liquid substance;Live Birth;Logistics;Longterm Follow-up;Magnetic Resonance Imaging;Mechanical ventilation;Methods;Modeling;mortality;Motion;multi-scale modeling;Natural History;next generation;novel;off-label use;Operative Surgical Procedures;Outcome;palliation;Patient Care;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Performance;Phase;Physicians;Physiologic pulse;Physiology;Population;Positioning Attribute;predictive tools;prevent;prospective;Public Health;reconstruction;Recording of previous events;Registries;Repair Complex;repaired;Resolution;respiratory;Risk;Safety;Scanning;Sedation procedure;Shapes;standard of care;Standardization;Structure-Activity Relationship;success;Surgeon;surgery outcome;Surgical Management;technique development;Techniques;Time;time use;Tissues;tool;Validation;Ventricular;virtual surgery;Work

PROJECT_TITLE: Expanding on a new paradigm for MRI in pediatric congenital heart disease

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The goal of this grant is to use and develop single-molecule technologies along with biochemical methods to examine the molecular mechanisms by which DNA mismatch repair proteins promote mutation avoidance, thereby reducing cancer risk, while also promoting trinucleotide repeat expansion, which causes several neurodegenerative diseases such as Huntington's. This research will both provide needed tools to the research community and further our understanding of the molecular mechanisms that underlie mismatch repair and trinucleotide-repeat expansion, which will be important for designing treatments for cancers and trinucleotide- repeat neurodegenerative diseases.

PI_NAMEs: ERIE, DOROTHY A (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Binding;Biochemical;cancer risk;cancer therapy;Communities;Complex;daughter strand;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;effective therapy;EXO1 gene;Fluorescence;Genetic Recombination;Genome;Genomics;Goals;Grant;Hereditary Malignant Neoplasm;Hereditary Nonpolyposis Colorectal Neoplasms;Huntington Disease;In Vitro;in vivo;innovation;insertion/deletion mutation;insight;Laboratories;Ligation;Malignant Neoplasms;Methods;Mismatch Repair;Molecular;Molecular Conformation;Mutation;Nature;Neurodegenerative Disorders;Organism;Play;prevent;Process;Proteins;recruit;Regulation;repaired;Replication Error;Research;Resistance;response;Role;single molecule;Techniques;Technology;technology development;therapy design;tool;Treatment-Related Cancer;Trinucleotide Repeat Expansion;Trinucleotide Repeats

PROJECT_TITLE: Integrative single molecule studies: DNA repair and technology development

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Palliative Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Project Narrative Despite an increase in telehealth for outpatient palliative care since the beginning of the COVID- 19 pandemic, little is known about the perspectives on modality of outpatient palliative care among historically underserved patients and how communication may be impacted by a virtual mode of delivery for these patients who already experience inequities in receipt of goal- concordant care. This prospective cohort study uses a mixed-methods approach to examine and compare care experiences for in-person versus tele-palliative care provided to historically underserved patients and their caregivers and to evaluate palliative care provider perspectives on the perceived effectiveness of tele-palliative care for this population. Findings will provide a roadmap for health systems to improve patient-provider communication and identify strategies to promote cultural competence to improve experience and overall quality of palliative care delivered both in person and via telehealth to seriously ill patients and their family caregivers who have been historically marginalized in health care.

PI_NAMEs: BANDINI, JULIA  (contact);HARRISON, JORDAN M

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Academic Medical Centers;Address;Adult;Advance Care Planning;Area;care providers;care systems;Caregivers;Caring;cohort;Communication;Communities;Consensus;COVID-19 pandemic;cultural competence;Effectiveness;end of life;end of life care;end-of-life communication;Enrollment;ethnic minority;Ethnic Origin;experience;Family;Family Caregiver;Feeling;Goals;health disparity;Health Personnel;Health system;Healthcare;Hearing;Human;Improve Access;improved;Inequity;Interview;Life;Limited English Proficiency;low socioeconomic status;marginalization;Measures;medical specialties;Methods;metropolitan;Modality;multidisciplinary;Outpatients;Pain intensity;Pain management;pain reduction;Palliative Care;Patient Care;patient-clinician communication;Patients;Persons;poor health outcome;Population;preference;Process;Prognosis;programs;Prospective, cohort study;Quality of Care;Quality of life;racial difference;racial minority;Recommendation;Reporting;Research;Risk;Rural;rural area;rural dwellers;rural setting;Sampling;Site;Socioeconomic Status;Spirituality;Surveys;symptom management;telehealth;Testing;time use;Trust;Underserved Population;virtual;Visit;Work

PROJECT_TITLE: Improving Serious Illness Care for Underserved Populations: Patient and Caregiver Experience with Tele-Palliative Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rare Diseases

PI_NAMEs: ROSEN, HOWARD J (contact)

PROJECT_TERMS: actigraphy;Address;Affect;Aging;Alleles;Atrophic;Attenuated;Behavior;Behavioral;Biological;Biological Factors;Biological Markers;Blood Vessels;Brain;brain volume;Cardiovascular Diseases;cardiovascular disorder risk;Caregivers;cerebral atrophy;Cerebrospinal Fluid;cerebrovascular health;Clinical;clinical heterogeneity;clinical predictors;Clinical Trials;Cognition;Cognitive;Cognitive aging;Data;Development;Disease;Emotions;Exercise;experience;Female;Frontotemporal Dementia;Genes;Genetic;genetic variant;glial activation;Goals;Health;healthy aging;Heterogeneity;Heterozygote;Image;immune activation;Impairment;indexing;Individual;Inflammatory;Inherited;Intervention;Language;Life Style;lifestyle factors;Light;Link;Magnetic Resonance Imaging;Maps;Measurable;Measures;Modeling;Modernization;modifiable behavior;modifiable risk;Molecular;molecular marker;motor symptom;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;novel;older adult;Other Genetics;Outcome;Outcome Measure;Participant;participant enrollment;Patients;Pattern;Persons;Physical activity;Physiology;predictive modeling;predictive tools;protein TDP-43;Proteins;Proteomics;Residual state;resilience;Risk Factors;risk stratification;sex;Signal Transduction;Sleep;Speed;Stratification;Stratification Factors;Structure;Surveys;Symptoms;Synapses;Syndrome;targeted treatment;tau Proteins;Techniques;Testing;Time;tool;Variant;white matter

PROJECT_TITLE: Heterogeneity in FTD Clinical Trials: New Mechanisms and Measures


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Prostate needle biopsies, often carried out under multiparametric MRI guidance, provide essential histopathological and gene transcript data for risk assessment. Major goals of the proposal are to improve needle biopsy targeting for procurement of tissue representative of highest grade group and expression of prostate transcripts of aggressiveness (PTAs), and to define and minimize effects from preanalytical tissue processing variables for analysis of PTAs. These steps will reduce the uncertainty in risk assessment and selection of men for active surveillance, single modality treatment, and multi-modality treatment.

PI_NAMEs: GASTON, SANDRA M;POLLACK, ALAN  (contact);STOYANOVA, RADKA

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Address;Affect;analytical method;Biological Assay;Biological Sciences;Biopsy;Biopsy Specimen;Categories;Characteristics;Classification;clinical imaging;clinical practice;Clinical Trials;Combined Modality Therapy;Core Biopsy;Data;Detection;Disease;Distant Metastasis;Early Detection Research Network;experience;Fixatives;Formalin;Freezing;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genomic signature;Gleason Grade for Prostate Cancer;Goals;Habitats;high risk;Human;Image;Image Analysis;imaging system;imprint;improved;large datasets;Lesion;Location;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Membrane;men;Methods;Modality;Modeling;Molecular;National Comprehensive Cancer Network;Needle biopsy procedure;Needles;Paraffin Embedding;Paraffin Tissue;participant enrollment;Pathologic;patient derived xenograft model;Patients;Pattern;portability;Positioning Attribute;predictive signature;preservation;Printing;Probability;Procedures;prognostic;prognostic signature;Prostate;prostate biopsy;prostate cancer model;prostate cancer risk;Prostatectomy;Prostatic Neoplasms;Protocols documentation;Pyroxylin;quantitative imaging;Quantitative Reverse Transcriptase PCR;radiomics;Reader;Recommendation;Regional Disease;Reporting;Reproducibility;Risk;Risk Assessment;risk selection;RNA;sample fixation;Sampling;Sampling Errors;Specimen Handling;standard of care;Standardization;Stratification;System;Techniques;Temperature;Testing;Time;Tissue Fixation;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Touch sensation;Transcript;transcriptome sequencing;transcriptomics;tumor heterogeneity;Tumor Volume;Uncertainty;Work

PROJECT_TITLE: Prostate Needle Biopsies: Impact of Preanalytical Procurement and Processing Variables on the Detection of Gene Expression Signatures of Prostate Cancer Aggressiveness


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Throughout the animal kingdom, social species establish social hierarchies and use social rank to guide the appropriate expression of dominance behaviors that are critical for survival. Our proposed mouse model research will characterize how orbitofrontal cortex neurons process social ranking information and evaluate how their interactions with serotonergic systems influence the expression of social dominance behaviors. Developing a better understanding of the neuronal mechanisms governing the appropriate expression of social behaviors will provide great value to clinicians and translational researchers wanting to treat impairments in control of social behaviors that are found in psychiatric disease.

PI_NAMEs: CAZARES, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: analytical tool;Animals;autistic;Behavior;Behavioral;Biological Assay;Biological Markers;biomarker identification;Brain;Calcium;Clinical;Code;Cognition;Cognition Disorders;cognitive ability;cognitive disability;Competitive Behavior;Complex;Computer Analysis;Data;data modalities;Decision Making;Detection;Development;Disease;Dissection;dorsal raphe nucleus;Electrophysiology (science);Emotions;Ensure;Environment;Event;evidence base;flexibility;Future;Gene Mutation;Genes;Genetic;Genetic Models;Goals;Health;Human;Hypothalamic structure;Image;Impaired cognition;Impairment;In Vitro;in vivo;Incidence;Individual;induced pluripotent stem cell;Knowledge;Lateral;Life;Link;Machine Learning;Medial;Mediating;Memory;Mental disorders;Mentorship;Methyl-CpG-Binding Protein 2;Modeling;molecular marker;mouse model;multimodality;Mus;Mutation;nerve supply;neural;neural circuit;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;neuroregulation;novel;optogenetics;Organoids;Outcome;Output;Participant;Patients;Periodicals;personalized medicine;Play;Population;Population Dynamics;post-doctoral training;Pre-Clinical Model;preclinical development;Prefrontal Cortex;Primates;Process;Property;Reporting;Research;Resources;response;Rett Syndrome;Rewards;Rodent;Role;Scalp structure;Serotonergic System;Serotonin;Severity of illness;social;Social Behavior;social competition;Social Controls;social deficits;Social Dominance;Social Environment;Social Hierarchy;Social Interaction;Sorting;Source;Structure;success;Symptoms;System;Techniques;Testing;Time;tissue culture;Training;transcriptome;translational scientist;Work

PROJECT_TITLE: Developing multimodal biomarkers of cognitive ability in a genetic model of neurodevelopment


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative This innovative study will establish a new oncogenic pathway as a therapeutic target for the treatment of lung, colon, and other tumor-types. 1

PI_NAMEs: GREGORY, RICHARD I. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: American;cancer cell;Cancer Model;Clinic;Colon;Colon Adenocarcinoma;Disease;DNA Methylation;DNA Modification Methylases;Drug Targeting;druggable target;effective therapy;Epigenetic Process;epitranscriptome;Gene Expression;Goals;Growth;high throughput screening;histone methyltransferase;histone modification;Human;innovation;Lung;Lung Adenocarcinoma;Malignant Neoplasms;Maps;Medicine;Messenger RNA;Methylation;Methyltransferase;Modification;Mus;new therapeutic target;Normal tissue morphology;Oncogenes;Oncogenic;Pathway interactions;posttranscriptional;RNA methylation;Role;small molecule;Testing;Therapeutic Intervention;therapeutic target;tumor;Work;Xenograft procedure

PROJECT_TITLE: Role of the Epitranscriptome in Cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative This study proposes to collect friendship data from two cohorts of students attending 14 schools in southern California. The friendship nominations will be used to determine if adolescents are influenced by their friends to initiate or continue e-cigarette and marijuana use. The longitudinal data will also be used to determine if adolescents make changes in their networks to be consistent with substance use behaviors and to determine if substance use patterns (trajectories) are associated with network changes.

PI_NAMEs: VALENTE, THOMAS W (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Adolescent;adolescent health;Affect;Behavior;Belief;Benefits and Risks;California;Cessation of life;Characteristics;Cigarette;cigarette smoking;Clinical;cohort;combustible cigarette;combustible tobacco;Complex;Consent;Consultations;Data;Data Collection;Development;Diffuse;Disease;Electronic cigarette;electronic cigarette use;electronic cigarette user;Electronic Nicotine Delivery Systems;Ethnic Origin;Friends;Friendships;Funding;Growth;Growth Factor;Health;high risk;high school;High School Student;human subject protection;Individual;Institutional Review Boards;Interview;Letters;Link;Marijuana;marijuana use;Measures;Modeling;Names;Nature;nicotine use;ninth grade;parental influence;Pathway Analysis;Pattern;peer influence;peer networks;Perception;Persons;Persuasive Communication;polytobacco;Population;preference;Prevalence;Prevention Research;Process;protective factors;Public Health;recruit;Reporting;Research;response;Risk;Risk Factors;risk perception;Role;Sampling;school district;Schools;Sex Orientation;Shapes;social;Social Change;Social Identification;Social Network;South Dakota;Students;Subgroup;substance use;Techniques;Testing;Time;tobacco products;Tobacco use;tobacco user;United States;uptake;vaping;Work;young adult;Youth

PROJECT_TITLE: Using Social Network Analysis to Understand Peer Influences on ENDS Use


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative An estimated 50% of women will experience Lower urinary tract symptoms – a source of illness, pain, and embarrassment, which can affect work, social interactions, and athletic and recreational activities from adolescence through old age. Through its transdisciplinary team science approach, the Prevention of Lower Urinary tract Symptoms Research Consortium has created new conceptual models and paradigms, developed innovative measures, established evidence, and lead and seeded research on bladder health and LUTS prevention. The objective of this program is to carry out epidemiologic studies, including the launch of a longitudinal cohort study, to identify risk and protective factors that can support prevention of lower urinary tract symptoms in girls and women across the lifecourse.

PI_NAMEs: MCGWIN, GERALD ;RUDSER, KYLE  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Address;Adolescence;Adopted;Advocate;Affect;aged;Athletic;Attitude;Award;bedwetting;Behavior;Belief;Biology;Biometry;biopsychosocial;biopsychosocial factor;Biostatistical Methods;Bladder;Classification;Clinical;clinical care;Collaborations;Communities;Community Developments;community engaged approach;Community Networks;Data;Data Analyses;Data Collection;Data Coordinating Center;data management;design;Development;Device or Instrument Development;Disease;empowerment;Enuresis;Environment;epidemiology study;Ethics;Evaluation;evidence base;experience;Feasibility Studies;Fostering;Future;girls;Goals;Grant;Health;health determinants;Health Status;Housing;human old age (65+);innovation;instrument;Intervention;Knowledge;Lead;Leadership;Learning;Life Cycle Stages;life span;Longitudinal cohort study;lower urinary tract symptoms;Measurement;Measures;meetings;member;men;micturition urgency;Modeling;modifiable risk;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Observational Study;Pain;Pathology;Perception;Persons;Phase;Pilot Projects;population based;Positioning Attribute;prevent;Prevention;Prevention strategy;Primary Prevention;Process;programs;prospective;protective factors;Psychometrics;Quality of life;Recreation;Research;Research Personnel;research study;Review Literature;Risk Factors;Role;Science;Secondary Prevention;Site;Social Interaction;Societies;Source;Stress Urinary Incontinence;Symptoms;Techniques;Testing;Treatment Efficacy;Update;Urethra;Urinary Incontinence;Urinary tract infection;Urination;urologic;web site;Woman;Work

PROJECT_TITLE: Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium Scientific and Data Coordinating Center


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Ribosomal RNA (rRNA), transfer RNA (tRNA), and messenger RNA (mRNA) are subjected to regulated and dynamic tissue-specific, signaling-specific, or disease-specific chemical modifications, many of which appear to regulate the fate and function of these RNAs. Although N6-methyladenosine (m6A) in mRNA comprises the major focus of the scientific community, other highly prevalent, and possibly similarly important, modifications in rRNA, tRNA and mRNA have not been studied in similar depth due to the lack the tools to quantify their precise stoichiometries in a site-specific and high-throughput manner. The Center for Quantitative and Site-Specific Analysis of RNA Modifications comprises an interdisciplinary and highly synergistic group of investigators who will develop a suite of enabling technologies that will provide the foundational tools, datasets, protocols, and concepts regarding modified nucleotide function, which will be needed to unravel the function of the still unresolved epitranscriptomic code in rRNA, tRNA, and mRNA.

PI_NAMEs: JAFFREY, SAMIE R (contact);MEYER, KATHRYN D

PROGRAM_OFFICER_NAME: NOVA, IAN CURTIS

PROJECT_TERMS: Acceleration;Address;Affect;Area;Biological Assay;Biology;Cell Physiology;cell type;Cells;Chemicals;Code;Communities;Complex;Coupled;Cryoelectron Microscopy;Data;Data Set;Disease;Education and Outreach;Ensure;epitranscriptome;epitranscriptomics;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Goals;human tissue;insight;Knowledge;Maps;Mass Spectrum Analysis;Mediator;Messenger RNA;Methods;minority trainee;Mission;Modification;Molecular Conformation;Multiprotein Complexes;new technology;novel;Nucleotides;online resource;Pathogenesis;Pattern;Peptide Synthesis;Post-Transcriptional Regulation;posttranscriptional;Protocols documentation;Pseudouridine;Regulation;Regulator Genes;Research;Research Personnel;Research Project Grants;Ribose;Ribosomal Interaction;Ribosomal RNA;Ribosomes;RNA;RNA analysis;RNA Caps;RNA Stability;RNA, Ribosomal, 28S;RNA-Binding Proteins;Role;Signal Transduction;single molecule;single-molecule FRET;Site;stoichiometry;Structure;sugar;symposium;Techniques;Technology;Time;Tissue atlas;Tissues;tool;Training;transcriptome;transcriptome sequencing;Transfer RNA;Translating;Translations;undergraduate research;Underrepresented Minority;virtual;Visit;web site;Work

PROJECT_TITLE: Center for Genomic Information Encoded by RNA Nucleotide Modifications


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Human Genome;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative: As a group, skin cancers are the most commonly diagnosed and treated malignancies in the United States. Increasing age and ultraviolet light exposure are the two most prominent epidemiologic risk factors for the development of skin cancer and are associated with epigenetic changes, like altered DNA methylation. The goal of this study is to define the importance of, and mechanisms responsible for, altered epigenetic states in the progression from normal to cancerous skin.

PI_NAMEs: CHEN, DAVID  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Academic Medical Centers;Academic support;Acute Myelocytic Leukemia;Affect;Age;age related;age related changes;aged;Aging;Award;Basal Cell;Biological Markers;bisulfite sequencing;Blood Cells;C57BL/6 Mouse;cancer genomics;Cancer Patient;Cancerous;Carcinoma;career;career development;cell age;Cell Aging;Cells;chemical carcinogenesis;Clinical;Clonal Expansion;Cytokeratin-14 Staining Method;Data;design;Development;Diagnosis;Disease;DNA;DNA Damage;DNA Methylation;DNA Modification Methylases;DNA Sequence Alteration;DNMT3a;DNMT3B gene;Elderly;Enterobacteria phage P1 Cre recombinase;Enzymes;Epidemiology;Epidermis;Epigenetic Process;epigenetic regulation;Event;Exhibits;Exposure to;Gene Expression;Gene Expression Profile;Genes;Genetic;Genomics;Goals;Growth;Human;improved;In Vitro;in vivo;Individual;Induced Mutation;insight;Island;keratinocyte;Keratinocyte cancer;KRAS2 gene;KRASG12D;loss of function mutation;LoxP-flanked allele;Lung Neoplasms;Malignant Neoplasms;Mediating;medical schools;Mentors;Mentorship;Methylation;Methyltransferase;Methyltransferase Gene;Modeling;mouse model;Mus;Mutagens;Mutate;Mutation;Names;Neoplastic Cell Transformation;next generation sequencing;normal aging;novel strategies;novel therapeutics;Oncogenic;pancreatic neoplasm;Pathogenesis;Pathway interactions;Patient Care;Patients;Persons;Phenotype;Physicians;Population;Predisposition;premalignant;Prevention;Process;Program Development;promoter;Property;Proto-Oncogenes;Recurrence;Research;Research Personnel;Research Project Grants;Resources;Risk;Risk Factors;Role;Scientist;single-cell RNA sequencing;Skin;Skin Aging;Skin Cancer;Skin Carcinogenesis;Skin Malignancy;skin organogenesis;Skin tumorigenesis;Somatic Mutation;Squamous cell carcinoma;Study models;Testing;Transgenic Model;tumor;tumor initiation;tumorigenesis;United States;Universities;Up-Regulation;UV Radiation Exposure;UVB induced;Washington;whole genome;Work

PROJECT_TITLE: Epigenetic Regulation of Cutaneous Tumorigenesis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SANTA CRUZ

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative In this proposal we will carry out the first unbiased screens and genetic interaction mapping of all lncRNAs and their associated protein partners in human and murine macrophage cells. We will generate genetic mouse models of candidate genes to show their critical role in contributing to sepsis in vivo. Our aim is to identify those functionally conserved lncRNAs involved in the regulation of critical biological processes in macrophages.

PI_NAMEs: CARPENTER, SUSAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Binding Proteins;Biological Process;Biology;Candidate Disease Gene;Cell Line;Cells;Complex;Data;deep sequencing;gene network;Genes;Genetic;Genetic Transcription;Genome;Goals;Human;Human Genome;Immune response;in vivo;Inflammatory;innovation;insight;Macrophage;Maps;mouse model;Mus;Names;novel;Pathway interactions;Proteins;Rapid screening;Regulation;Reporter;RNA;Role;Sepsis;Signal Transduction;Technology;Untranslated RNA

PROJECT_TITLE: High throughput functional characterization of lncRNAs in macrophage biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Although artificial intelligence (AI) has shown theoretical promise to mitigate pediatric sepsis, which is a leading cause of morbidity and motility pediatric care, in practice, AI-based interventions have had mixed results. These mixed results are difficult to interpret because current approaches to measure AI system performance are inadequate as they do not establish the causal mechanisms for what is a complex intervention. This study will establish feasibility of measuring mechanism of impact via human performance measures in real world acute care settings.

PI_NAMEs: KANDASWAMY, SWAMINATHAN  (contact)

PROGRAM_OFFICER_NAME: RODRICK, DAVID

PROJECT_TITLE: Human Factors and Implementation Evaluation of Pediatric AI Sepsis Model in the Pediatric Emergency Department


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative As one of four Centers of Excellence (COEs) of FDA's Center for Food Safety and Applied Nutrition, JIFSAN conducts various research and outreach activities in food safety and applied nutrition to help ensure that regulatory decisions have a sound science footing and that the best methods and tools are available to advance food and public health. The JIFSAN's programs support the Food Safety Modernization Act that emphasizes the concept of preventing food safety-related problems before they occur and enhance FDA's efforts to partner with other nations to improve U.S. and worldwide health.

PI_NAMEs: MENG, JIANGHONG  (contact)

PROGRAM_OFFICER_NAME: RANDOLPH, KELLY

PROJECT_TITLE: Cooperative Agreement to Support the Joint Institute for Food Safety and Applied Nutrition (JIFSAN)


NIH_SPENDING_CATS: Clinical Research;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: MAYWOOD

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Foundational work in bladder health research was completed during the first PLUS funding cycle, with significant transdisciplinary contributions and expertise of the Loyola Clinical Center (LCC) investigators who will work collaboratively in the next funding cycle toward the over-arching goal of advancing bladder health through the final design, conduct and analysis of a large, US population-based observational cohort of women across the life-span, using the Bladder Health Instrument which PLUS developed and validated. Our LCC trans-disciplinary team of researchers plan to conduct high-impact research that challenge existing paradigms and improve research approaches in bladder health, with a focus on musculoskeletal interventions and urobiome research. With the LCC as an integral component of the PLUS Research Consortium, we expect rapid improvements in scientific knowledge and LUTS prevention strategies that will benefit and support the broader research community with particular impact on the broader urology community and women’s health.

PI_NAMEs: BRUBAKER, LINDA ;FITZGERALD, COLLEEN MARIE (contact)

PROJECT_TERMS: adolescent woman;Adult women;Behavior;biobank;Biological;Biology;Biomass;Bladder;Characteristics;clinical center;cohort;Collaborations;Collection;Communities;community engaged research;community engagement;cost;Data;design;Development;Ecology;Evaluation;evidence base;Funding;Future;Goals;Health;Home;Human;improved;Individual;innovation;instrument;Intervention;Intervention Studies;Investigation;Knowledge;Life;Life Cycle Stages;life span;Longitudinal cohort study;Longitudinal Studies;Lower urinary tract;lower urinary tract symptoms;Measurable;microbial;Mission;multidisciplinary;Musculoskeletal;novel;Participant;Patients;Pelvic Floor Muscle;Persons;Physical Examination;Pilot Projects;population based;Positioning Attribute;prevent;Prevention;Prevention strategy;Process;promoter;protective factors;Proxy;recruit;repository;Research;Research Activity;Research Personnel;Research Priority;Resources;Risk;Risk Factors;Sampling;Shipping;Specimen;success;Surveys;Time;tool;Urinary Microbiome;Urine;Urology;validation studies;Visit;Women's cohort;Women's Health;Work

PROJECT_TITLE: PLUS Loyola Clinical Center


ORG_CITY: Taylorsville

ORG_NAME: UTAH DEPARTMENT OF AGRICULTURE/FOOD

PHR: PAR-21-174 Utah Project Narrative  The Utah Produce Safety Program will educate and enforce the safe production of fresh fruits and vegetables and promote understanding and compliance with the requirements of FDA’s Produce Safety Rule, 21 CFR 112, Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption. UDAF Regulatory Services, Plant Industry and Utah State University Cooperative Extension have been engaged in working together to implement the Utah Produce Safety Program. This program will cover these objectives:  • Self-Assessment and Strategic Planning  • Program Administration  • Education, Outreach and Technical Assistance  • Farm Inventory  • Inspection Program  • Compliance and Enforcement  • Produce Related Event Response Planning and Implementation We will conduct an annual self-assessment and set goals for each FOA objective in our Strategic Plan and Project Outline. The UDAF Produce Safety Program will continue to monitor our Program Administration as needed to be successful in each objective listed above and develop a plan of succession. We will continue to monitor and report on Project Outline goals for Outreach and Education, Farm Inventory, Inspection Program elements, Compliance and Enforcement and Produce Related Event Response Planning and Implementation.

PI_NAMEs: BASINGER, DAVID  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path C The State of Utah Cooperative Agreement to Implement and Enhance a Produce Safety Program


NIH_SPENDING_CATS: Genetics;Human Genome;Nutrition;Obesity

ORG_CITY: LITTLE ROCK

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Obesity-induced metabolic deregulation is linked to increased bone fragility. However, bone is also a crucial driver of energy metabolism, yet the impact of obesity on the bone’s metabolic function remains unclear. Here, we test the possibility that obesity disrupts osteocyte-intrinsic energy metabolism that in turn contributes to deregulation of systemic energy balance. Testing this hypothesis will advance our understanding of the cellular and molecular mechanisms that mediate the crosstalk between bone and metabolic tissues, which will improve the success of clinical efforts to reestablish energy balance while protecting musculoskeletal health in obesity. Project Narrative

PI_NAMEs: DOLE, NEHA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;age related decline;ATAC-seq;Behavior;Biochemical;bone;bone cell;bone fragility;Cell Reprogramming;Cells;ChIP-seq;Chromatin;Clinical;Cues;Data;Diet;diet-induced obesity;Disease;Dose;Eating;energy balance;Energy Metabolism;Epidemic;Epigenetic Process;epigenome;Equilibrium;Foundations;Functional disorder;Future;glucose metabolism;Glycolysis;Goals;Health;High Fat Diet;histone modification;Hormones;Hyperglycemia;Hyperlipidemia;improved;In Vitro;in vivo;insight;Intervention;Knowledge;Link;lipid metabolism;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Mitochondria;Modeling;Molecular;Monitor;multiple omics;Mus;Musculoskeletal;Neurosecretory Systems;novel;Nutrient;Nutritional;Obesity;Osteocytes;outcome prediction;Oxidative Phosphorylation;Pathway interactions;Pattern;pharmacologic;Phenotype;Physiological;Play;Prevalence;programs;Regulation;Research;response;Role;Serum;Shapes;Signal Transduction;SIRT1 gene;Skeleton;success;Testing;Therapeutic;Thinness;Time;Tissues;trait;transcriptome;transcriptome sequencing;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Weight Gain;Work

PROJECT_TITLE: Unraveling the role of osteocytes in metabolic dysfunction associated with obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative  The genome is spatially organized within the nucleus and the position of genes can impact gene expression. The proposed work will 1) define the molecular mechanisms that control the spatial organization of the genome in a simple model system and 2) determine how gene interactions with the nuclear pore complex impact gene expression.

PI_NAMEs: BRICKNER, JASON HAYS (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Aging;Animals;Biological Models;Cell Nucleus;Cells;Chromatin Structure;Chromosomes;Complex;Environment;Future;Gene Expression;gene interaction;Gene Order;Genes;Genetic Transcription;Genome;Goals;Human;Life Style;Mediating;Molecular;Nuclear Pore Complex;Physiology;response;Saccharomycetales;Signal Transduction;transcription factor;Transcriptional Regulation;Work;yeast genome

PROJECT_TITLE: The molecular mechanisms and functional significance of gene positioning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Abnormal development of the hemochorial placenta contributes to pregnancy complications and is a significant health issue for mother and fetus. The uterine-placental interface is a complex environment that represents the site of trophoblast cell-guided transformation of uterine cell populations. Identifying regulatory pathways controlling the uterine-placental interface will provide insights into the development of diagnostics and therapeutic interventions for pregnancy-related disorders.

PI_NAMEs: SIMON, MIKAELA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abate;Activins;Address;Affect;antagonist;Biological;Blood flow;candidate identification;Cell Communication;Cell Differentiation process;Cell Lineage;Cell Proliferation;Cells;Complex;CRISPR/Cas technology;Critical Thinking;Decidua;Development;diagnostic development;Disease;early pregnancy loss;Embryo;embryo cell;Environment;Exhibits;experimental study;female fertility;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetus;Follistatin;gain of function;genome editing;Genomics;Goals;Health;Hemochorial Placental Development;Human;In Vitro;in vivo;insight;Invaded;Kansas;Laboratories;Location;loss of function;Medical center;Medicine;Mentors;migration;Modeling;Molecular;Mothers;Mus;mutant;Nutrient;obstetrical complication;Pathogenesis;Pathology;Physiological;Physiology;Placenta;Placentation;Population;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Premature Birth;Process;Rattus;Regulation;Regulatory Pathway;reproductive;Research;restraint;Rodent;Role;Science;Scientist;shear stress;Signal Transduction;single-cell RNA sequencing;Site;skills;Spiral Artery of the Endometrium;stem;stem cell differentiation;Study models;Therapeutic Intervention;Training;Transcript;transcriptomics;trophoblast;trophoblast stem cell;Universities;Uterus;Villous

PROJECT_TITLE: Signaling at the Uterine Placental Interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alcohol is the third leading cause of preventable death worldwide yet; hepatic therapeutic interventions remain undiscovered. Preliminary data revealed that alcohol-mediated acetylation and redox signaling changes are dictated by the proximity of cysteine (thiol) residues to lysine residues. Understanding alcohol-induced proteome dysregulation will help identify potential therapeutic targets and pathways for combatting alcohol-induced liver damage.

PI_NAMEs: MCGINNIS, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acetaldehyde;Acetates;Acetylation;Advanced Development;Affect;Age;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;Amines;Amino Acids;Analytical Biochemistry;bench to bedside;Binding;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biophysics;Carbon;Cell Respiration;Cessation of life;Charge;Chemistry;Chronic;chronic alcohol ingestion;Classification;Clinical;clinically relevant;Consumption;Cysteine;Data;Data Set;detection method;Development;Drug Metabolic Detoxication;Early Diagnosis;enzyme activity;Enzymes;Equilibrium;Ethanol Metabolism;Ethanol toxicity;Evaluation;feeding;Fellowship;Goals;Grant;Hepatic;hepatoprotective;Homeostasis;improved;in vitro activity;in vivo;Individual;insight;interdisciplinary approach;Iron;Lead;Liver;Liver diseases;liver injury;Lysine;Mediating;Mentors;Mentorship;Metabolic;Metals;Mitochondria;Modeling;Modification;mouse model;Mus;National Center for Advancing Translational Sciences;National Institute on Alcohol Abuse and Alcoholism;National Research Service Awards;new therapeutic target;Nicotinamide adenine dinucleotide;novel;Outcome;oxidation;Oxidation-Reduction;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Post-Translational Protein Processing;prevent;preventable death;Preventive therapy;protein function;protein structure;Proteins;Proteome;proteomic signature;Proteomics;Reaction;Recombinants;regenerative therapy;Regulation;repaired;Research;Research Personnel;response;Role;Signal Transduction;Sirtuins;Site;Stress;Structure;success;Sulfhydryl Compounds;Supportive care;Therapeutic;Therapeutic Intervention;therapeutic target;Training;United States National Institutes of Health;Work;Zinc

PROJECT_TITLE: Regulation of hepatic lysine N-acetylation by cysteine proximity due to alcohol toxicity


NIH_SPENDING_CATS: Biotechnology;Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative Necrosis is a catastrophic lytic form of cell death that occurs in many diseases and injury contexts, and has significant consequences for human health. While other forms of cell death, such as apoptosis, are known to influence the ability of a tissue to recover and regenerate through defined signaling events, it is unknown whether these same events occur during necrosis, and whether they can be manipulated and augmented to improve healing outcomes. Our work will take advantage of the exceptionally powerful genetics of Drosophila, and a novel system we have developed to induce, manipulate and characterize necrosis, to understand the genetic factors and events necessary for necrosis-induced tissue repair.

PI_NAMEs: HARRIS, ROBIN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Ablation;Adult;Apoptosis;apoptosis inducing factor;Apoptotic;Behavior;Burn injury;Cell Death;Cell Separation;cell type;Cells;Cytoplasm;Dinoprostone;disc regeneration;Disease;Drosophila genus;Embryonic Development;Epigenetic Process;Erinaceidae;Event;experimental study;Frostbite;Generations;Genes;Genetic;genetic approach;genetic manipulation;genome sequencing;Growth;Growth and Development function;healing;Health;Hepatocyte;Homeostasis;Human;Human Development;imaginal disc;Impairment;improved;in vivo;Induction of Apoptosis;Infection;Injury;injury recovery;insight;ischemic injury;Liver;Liver Regeneration;Lytic;MAPK8 gene;Membrane;Modeling;Molecular;Mus;Myocardial Infarction;Natural regeneration;Necrosis;Necrosis Induction;next generation sequencing;novel;novel therapeutic intervention;Organ;Outcome;Pathway interactions;Pattern;Play;Process;programs;Proliferating;Recovery;regeneration following injury;regenerative;Regenerative capacity;release factor;repaired;response;Role;Signal Transduction;Signaling Molecule;stroke-like episode;System;tissue regeneration;tissue repair;Tissue Survival;Tissues;tool;transcriptomics;Traumatic injury;virtual;whole genome;Wing;Work;wound

PROJECT_TITLE: Understanding Necrosis-Induced Tissue Regeneration

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This grant is to train scientists to conduct genetic studies that will increase our understanding of the causation of - and specific brain abnormalities associated with - neurological and psychiatric diseases and traits related to them. These diseases affect millions of Americans. One of our best hopes of improving treatments or preventing these diseases is through rigorous investigations of genes and genetic variations in humans and model organisms.

PI_NAMEs: BEARDEN, CARRIE E;OPHOFF, ROEL A (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Genetic;Grant;neurobehavioral;Training

PROJECT_TITLE: Training Grant in Neurobehavioral Genetics


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative Neural Crest cells (NC) are critical for embryonic development and are associated with multiple pathologies including birth defects and cancer. Here we propose to study the contributions of messenger signaling molecules of the TGFb and WNT families during the earliest steps during the formation of NC. Our work combines a human model of NC development with chick embryos providing in vivo and in vitro advantages and perspectives.

PI_NAMEs: GARCIA-CASTRO, MARTIN I. (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Address;Amaze;Animal Model;Anterior;Area;Binding;Birds;Candidate Disease Gene;Cartilage;Cell Lineage;Cell model;cell type;Cells;Chick;Chick Embryo;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Congenital Abnormality;craniofacial bone;CRISPR/Cas technology;Development;Dorsal;Embryo;Embryology;Embryonic Development;Emigrations;Endothelin;Endowment;Epithelium;Erinaceidae;Event;experimental study;Face;Family;Female;Fibroblast Growth Factor;gain of function;Gene Expression Profile;Genetic;Genetic Transcription;Goals;Human;human model;improved;In Situ Hybridization;In Vitro;in vivo;innovation;knock-down;Knowledge;Ligands;loss of function;MADH2 gene;MADH3 gene;male;Malignant Neoplasms;Mediating;melanocyte;Melanoma;Mesenchymal;migration;Modeling;Molecular;Neural Crest;Neural Crest Cell;Neural Fold;neural plate;Neural tube;Neuroglia;Neurons;Nodal;notch protein;novel;orofacial cleft;Output;Pathology;Pathway interactions;Peripheral Nervous System;Play;Pluripotent Stem Cells;Population;Process;programs;rare condition;receptor;Research;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Small Interfering RNA;Stereotyping;Testing;Time;transcriptome sequencing;Tretinoin;vertebrate embryos;Vertebrates;WNT Signaling Pathway;Work

PROJECT_TITLE: Molecular Interactions during Neural Crest Formation

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF-M]


ORG_DEPT: PHYSICS

PHR: Project Narrative Public Health Relevance: In eukaryotes from single-celled fungi to mammals, metabolism takes place in the context of cells organized into spatial compartments known as organelles. In this proposal, we seek to illuminate the fundamental quantitative principles by which the cell coordinates the dynamic properties of its organelles, their regulation by gene expression, and the role coordinated organelle dynamics plays in cellular growth and metabolism. Knowledge of these principles can help uncover mechanisms underlying how cells develop normally into cell types and how in the context of disease, such as cancer and diabetes, they remodel their organelle composition to handle altered metabolic profiles and thus point toward potentially new targets for therapy.

PI_NAMEs: MUKHERJI, ARINDAM SHANKAR (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Biochemical;Biogenesis;Biological;Calibration;Categories;cell growth;Cell Proliferation;Cell Separation;cell type;Cells;Cellular biology;cellular development;Chemicals;Complex;Data;design;Diabetes Mellitus;Disease;Eukaryota;Eukaryotic Cell;flexibility;Foundations;fungus;Future;Gene Expression;Gene Expression Regulation;genetic manipulation;Goals;Growth;Health;imaging platform;Individual;insight;Investigation;Knowledge;Machine Learning;Malignant Neoplasms;Mammals;mathematical model;Measurement;Measures;Mediating;Metabolic;metabolic profile;Metabolism;metabolomics;Modeling;new therapeutic target;Organelles;Organism;Output;Pathology;Physiological;Play;Positioning Attribute;predictive modeling;programs;Proliferating;Property;public health relevance;Research;Role;Route;Shapes;Site;System;Testing;Visualization

PROJECT_TITLE: The design principles of the eukaryotic cell: uncovering the coordination of systems-level organelle dynamics, metabolism and growth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ORG_CITY: PORTLAND

ORG_DEPT: NEUROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Parkinson's disease (PD) is a neurodegenerative disease affecting millions of people globally and there are no therapeutic approaches that can stop or slow down disease progression. Recent research highlights the interaction of glia and neurons as a central mechanism contributing to neurodegeneration, and the advancement in genetic tools and microscopy techniques allows studying disease phenotypes with an exquisite level of detail. The proposed studies seek to examine how neurite defects lead to synaptic dysfunction, and assess the role of glia in PD pathogenesis, with the hope of discovering new therapeutic avenues to manage this devastating disease.

PI_NAMEs: PALLOS, JUDIT  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Address;Affect;Age;age related;aged;Aging;Apoptotic;Architecture;Astrocytes;autosome;Axon;calcium indicator;Cause of Death;Cell Death;Cells;Cessation of life;Defect;Development;Disease;disease model;disease phenotype;Disease Progression;Dopamine;dopaminergic neuron;Drosophila genus;Economic Burden;Elderly;Event;Exhibits;experimental study;fly;Foundations;Functional disorder;Functional Imaging;Future;Genetic;Goals;Homeostasis;Hypertrophy;Idiopathic Parkinson Disease;imaging approach;Impairment;improved;In Vitro;in vivo;insight;Intervention;Late-Onset Disorder;Lead;Length;life span;LRRK2 gene;Mediating;Membrane;Metabolic;Microscopy;Missense Mutation;Modeling;Monitor;Morphology;Motor;Movement Disorders;mutant;Mutation;Nerve Degeneration;Nervous System;Neurites;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Injury;Neurons;neurotransmission;novel;novel therapeutic intervention;novel therapeutics;Organism;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Persons;Phagocytes;Phagocytosis;Phenotype;Physiological;Play;Population;prevent;Quality of life;receptor;Reporter;Research;Risk;Role;Signal Transduction;Societies;Synapses;synaptic function;Techniques;Technology;Temperature;Testing;Therapeutic;Tissues;tool;Translating;United States

PROJECT_TITLE: Role of glia in LRRK2 mediated dopaminergic neuron degeneration


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: The long-term objective is to develop therapeutic approaches for mutation-specific TCRs to eradicate cancer in patients. The immediate objective is to utilize in vitro assays and animal models that mimic human cancers in order to maximize translational potential. Results obtained by experimentation in animals will suggest new approaches and provide a blueprint for making mutation-specific TCR treatment effective in humans with advanced tumors.

PI_NAMEs: SCHREIBER, HANS  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Transfer;Algorithms;Animal Model;Animals;antigen-specific T cells;Antigens;cancer cell;Cancer Relapse;cancer type;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell type;Cells;cellular transduction;chemotherapeutic agent;Clinic;Clinical;Clone Cells;Collaborations;Cross Presentation;Data;Diagnosis;Diameter;Elements;Epitopes;Equilibrium;Funding;Genes;Genetic;Growth;Heterogeneity;Human;Image;Immune checkpoint inhibitor;Immunity;Immunotherapy;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;Individual;ITGAM gene;Malignant - descriptor;Malignant Neoplasms;Mediating;Messenger RNA;MHC Class I Genes;MHC Class II Genes;Molecular;mRNA Expression;mutant;Mutation;Nature;neglect;neoantigens;Normal tissue morphology;novel;novel strategies;Outcome;Patients;peripheral blood;Phase;prevent;Prognosis;Relapse;relapse prevention;Research;Solid;Solid Neoplasm;Stromal Cells;Stromal Neoplasm;synergism;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;tandem mass spectrometry;Testing;Therapeutic;Time;Transfection;translational potential;tumor;tumor growth;tumor microenvironment;Tumor-associated macrophages;Tumor-Infiltrating Lymphocytes;Variant

PROJECT_TITLE: Manipulation of Tumor Specific Immunity

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Clinical Research;Hematology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: JACKSON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE This study is motivated by the observation that platelets are frequently dysfunctional immediately following severe injury, a phenomenon which is associated with worse outcomes but which remains poorly understood and therefore inadequately treated. Based on observational studies of injured patients and mechanistic studies in other disease states, there is evidence that mitochondrial DNA released in response to injury acts directly on platelets, leading to platelet dysfunction and impaired systemic fibrinolysis. This proposal aims to evaluate the effect of mitochondrial DNA on platelets by examining a core set of platelet and fibrinolytic functional assays, as applied to an observational human study to gain key clinical insights, a study of isolated platelets in which to probe mechanisms, and an animal study in which to replicate human findings and evaluate potential therapies.

PI_NAMEs: KUTCHER, MATTHEW E (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Advisory Committees;Agonist;Animal Model;Animals;Antifibrinolytic Agents;arm;Award;Bilateral;Biological Assay;Biological Markers;Biology;Blood Coagulation Disorders;Blood Platelets;career;Cause of Death;Cessation of life;Clinical;clinical practice;Clinical Research;Coagulation Process;Cohort Studies;Complex;Critical Illness;Cytoplasmic Granules;Data;Deoxyribonucleases;design;Development;Disease;Endothelial Cells;Exhibits;experience;Extramural Activities;Feedback;Fibrinolysis;Foundations;Functional disorder;Functional impairment;Funding;Goals;Hemorrhage;Hindlimb;Human;human study;Immune;Impairment;improved;improved outcome;In Vitro;Inflammation;Inflammatory;inhibitor;injured;Injury;insight;Institution;interest;Intervention;Intravenous;Knowledge;Length of Stay;Mediating;Mediator;Medical center;Mentored Clinical Scientist Development Award (K08);Mentors;Mentorship;Metformin;Mississippi;Mitochondria;Mitochondrial DNA;Modeling;Molecular;mortality;Multiple Organ Failure;new therapeutic target;novel;novel therapeutics;Observational Study;Operative Surgical Procedures;Organ failure;Orthopedics;Outcome;particle;Pathogenesis;Patients;Pattern;pharmacologic;Phenotype;Physiology;Plasma;Platelet Activation;platelet function;platelet phenotype;Play;pre-clinical;Prevalence;prospective;Refractory;Research;Research Personnel;response to injury;Rest;Resuscitation;Rodent;Rodent Model;Role;Scientist;severe injury;skill acquisition;Surgeon;targeted treatment;Testing;Thrombosis;Training;Transfusion;Translating;translational approach;translational pipeline;translational study;Trauma;trauma induced coagulopathy;Trauma patient;Trauma Research;Universities;Work

PROJECT_TITLE: Mitochondrial DNA in the pathogenesis of post-injury coagulopathy

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease

PHR: RELEVANCE TO PUBLIC HEALTH Chronic ischemic heart disease (IHD) continues to be the number one cause of morbidity and mortality in patients with kidney disease. Contrast-enhanced stress perfusion cardiac magnetic resonance imaging (MRI) for detection of IHD provides high quality images and lacks ionizing radiation, but has technical shortcomings. We propose to develop a new framework for steady state cardiac MRI stress testing that can potentially overcome many drawbacks of stress gadolinium perfusion MRI while heightening its impact across a broad spectrum of patients with renal dysfunction.

PI_NAMEs: NGUYEN, KIM-LIEN T (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Adenosine;Adult;Affect;Anatomy;Angiography;Autopsy;Beds;Biodistribution;Blood capillaries;Blood flow;Blood Vessels;Blood Volume;Bolus Infusion;Cardiac;cardiac magnetic resonance imaging;Cardiovascular system;Catheterization;Cause of Death;Chronic;Chronic Kidney Failure;Clinical;Clinical Management;clinical translation;contrast enhanced;Contrast Media;Coronary;cost effective;Darkness;Defect;density;Detection;detection method;Diagnosis;diagnostic accuracy;Diagnostic tests;Disease;Electric Capacitance;Event;experience;Family suidae;ferumoxytol;Future;Gadolinium;Goals;Health;high risk;Hyperemia;hypoperfusion;Image;imaging biomarker;imaging detection;Impairment;indexing;Infarction;Infrastructure;Intervention;Intravenous;Ionizing radiation;Iron;Iron deficiency anemia;Ischemia;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;Kidney Transplantation;Kinetics;Magnetic Resonance;Magnetic Resonance Imaging;Maps;Metabolic;Microvascular Dysfunction;Morbidity - disease rate;Morphologic artifacts;mortality;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardial perfusion;Myocardium;Nephrogenic Systemic Fibrosis;nephrotoxicity;Organ;Patients;Performance;Perfusion;Pharmaceutical Preparations;Population;Positron-Emission Tomography;pressure;Prevalence;Property;Protocols documentation;Public Health;Radiation;Recovery;recruit;Recurrence;Relaxation;Renal function;Resistance;Resolution;Rest;Risk;Safety;side effect;Signal Transduction;Stress;stress state;Stress Tests;Techniques;Testing;Time;Tissue Viability;Tissues;Vascular blood supply;Vasodilation;Work

PROJECT_TITLE: Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Hepatitis B virus is the world's leading cause of cirrhosis, liver cancer, and liver-related mortality. The proposed research project will address central questions of hepatitis B management in sub-Saharan Africa by using a novel simulation model to compare the clinical outcomes and cost-effectiveness of different strategies of hepatitis B treatment.

PI_NAMEs: MOHAREB, AMIR  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Address;Adult;Africa;Africa South of the Sahara;alternative treatment;Anti-viral Agents;Anti-viral Therapy;Applied Skills;Area;Award;Biometry;career;Caring;Cessation of life;Chronic Hepatitis B;chronic liver disease;Cirrhosis;Clinical;clinical epidemiology;Clinical Investigator;Clinical Practice Guideline;Collaborations;Communicable Diseases;Complex;Computer Simulation;cost;cost effectiveness;Cost Effectiveness Analysis;Country;Data;Derivation procedure;design;Diagnostic;Diagnostic tests;didactic education;Disease;Drug Side Effects;economic outcome;Economics;elastography;Eligibility Determination;Europe;evidence base;Far East;fighting;Flare;Foundations;Future;Goals;Guidelines;Health Benefit;Healthcare;Hepatitis;Hepatitis B;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Virus;HIV;Immunotherapy;improved;Incidence;International;Investigation;Ivory Coast;Laboratories;Liver;liver biopsy;Liver Fibrosis;Malaria;Malignant neoplasm of liver;Measures;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;model design;Modeling;models and simulation;Monitor;mortality;mortality risk;multidisciplinary;multiple data sources;North America;novel;Nucleic Acid Amplification Tests;Outcome;Patients;Persons;Physicians;Policy Maker;Positioning Attribute;prevent;Prevention;Primary carcinoma of the liver cells;Productivity;Public Health;Records;Research;Research Personnel;Research Project Grants;Resource-limited setting;Resources;Safety;scale up;skills;Solid;standard of care;Strategic Planning;success;tool;Training;treatment guidelines;treatment strategy;Tuberculosis;United States National Institutes of Health;Vaccination;Vaccines;Validation;Viral;viral DNA;Viral hepatitis;Virus;Withholding Treatment;World Health Organization;years of life lost

PROJECT_TITLE: Simulation Modeling of Hepatitis B Virus Elimination Strategies in Cote d'Ivoire

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ORG_CITY: CHARLESTON

ORG_NAME: WEST VIRGINIA STATE DEPT OF AGRICULTURE

ORG_STATE: WV

PHR: West Virginia Department of Agriculture  Laboratory Flexible Funding Model PAR-20-105  Narrative - Overall Increased surveillance sample analysis can prevent contaminated human and animal food from causing illnesses. The proposed project will increase the overall testing capabilities and capacities of food testing in West Virginia. This mitigation will directly decrease the risk of contaminated foods from reaching endpoint consumers.

PI_NAMEs: YOUNG, MEGAN SUSANNE (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Enhancing the Capability and Capacity of Human and Animal Food Testing Laboratories within West Virginia under the Laboratory Flexible Funding Model


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project narrative Leveraging the big data generated by large consortiums, e.g., ENCODE, Roadmap Epigenomics, GTEx, and Human Cell Atlas, we will perform a systematic survey of the usage of domesticated TEs-derived promoters in the human genome. We will identify the TEs that were domesticated as promoters of protein-coding genes and non-coding genes in the human genome, and further characterize the tissue-level expression pattern of domesticated TEs-derived transcripts, by using our established transcripts assemble pipeline to analyze the tissue bulk RNA-seq data generated by ENCODE and GTEx. We will investigate the cell-type-specific expression pattern of domesticated TEs-derived transcripts, by reconstructing the single-cell RNA-seq data analysis with novel bioinformatics analysis tool. We will apply comparative-genomics approaches to create the expression matrix of orthologous TEs-derived protein-coding genes across multi-species, and construct the phylogenetic trees to explore the expression pattern changes of TEs-derived protein-coding genes during evolution. Our study will significantly improve our understanding of the expression behaviors of domesticated TE- derived genes in human tissues and cell types, and reveal the contribution of domestication of TEs in gene transcription during human genome evolution.

PI_NAMEs: ZHANG, BO  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Atlases;Behavior;Big Data;Binding Sites;Bioinformatics;Biological Process;cell type;Cells;Code;comparative genomics;Data;Data Analyses;Development;DNA Transposable Elements;Elements;epigenetic silencing;epigenomics;Evolution;Genes;Genetic Transcription;Genome;Genomic approach;Genotype-Tissue Expression Project;Human;Human Genome;human tissue;improved;Mus;novel;Pattern;Phylogenetic Analysis;Play;promoter;Proteins;Rodent;Role;single-cell RNA sequencing;Surveys;Tissue Differentiation;Tissues;tool;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;Trees;Untranslated RNA

PROJECT_TITLE: Transcriptional regulation of domesticated transposable elements-derived promoters in human genome


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease

ORG_CITY: HARARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: COLLEGE OF HEALTH SCIS UNIV OF ZIMBABWE

PHR: Project Narrative The ENRCH program will be established at the University of Zimbabwe to initiate and intensify research in NCDs through training and mentoring of Masters, PhDs and Post-doctorals majoring in Cardiovascular Diseases, Pulmonary Diseases, Hematology, Stroke and Neurological Diseases, Aging and Dental and Craniofacial Diseases. The long-term goal is to generate evidence for interventions to improve care for people with NCDs in Zimbabwe and sub-Saharan Africa.

PI_NAMEs: MANASA, JUSTEN  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Africa South of the Sahara;Aging;Area;Cardiovascular Diseases;Caring;Collaborations;Colorado;craniofacial;Dedications;Dental;Disease;Doctor of Philosophy;Educational Status;experience;Faculty;Goals;Health Sciences;Hematology;improved;innovation;Institution;interest;International;Intervention;knowledge translation;Lead;life span;Lung Diseases;Medical center;Medical Research;Medicine;Mentors;Mentorship;Nervous System Disorder;Persons;Policies;Postdoctoral Fellow;programs;recruit;Research;research data dissemination;Research Personnel;Research Priority;Research Training;Selection Criteria;Short-Term Course;Stroke;Training;Training Activity;Universities;Zimbabwe

PROJECT_TITLE: Enhancing Non-communicable diseases Research and Innovation Capacity in Harare, Zimbabwe (ENRICH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Public Health Relevance Childhood cancer is the leading cause of death due to disease in children in the United States. Childhood cancer survivors, which number over 350,000, face lifelong increased morbidity and mortality. This training program equips researchers and physician-scientists with experience in classical epidemiology, genomic epidemiology, laboratory studies, and clinical investigations relevant to childhood cancer etiology, outcome, and survivorship.

PI_NAMEs: SPECTOR, LOGAN G. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: cancer epidemiology;Genomics;Grant;Malignant Childhood Neoplasm;Training

PROJECT_TITLE: Translational and Genomic Pediatric Cancer Epidemiology Training Grant

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Women's Health Research

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: AGA KHAN UNIVERSITY (KENYA)

PHR: PROJECT NARRATIVE – Overall Component Our proposed Research Hub, UZIMA-DS (UtiliZe health Information for Meaningful impact in East Africa through Data Science) will create a scalable and sustainable platform to apply novel approaches to data assimilation and advanced artificial intelligence/machine learning-based methods to serve as early warning systems to 1) improve health outcomes for at-risk mothers and children and 2) improve mental health outcomes for at-risk adolescents and young adults in Kenya. We will bring together method experts in statistics, computer science, and informatics, health domain experts and practitioners, and partnerships with key stakeholders to not only improve the quality, efficiency, and relevance of multidisciplinary data science in health research, but also its transparency, reproducibility, and dissemination for sustainable impact in Africa. Thus, helping ensure current and future generations of Africans can achieve uzima (health/well-being in Swahili).

PI_NAMEs: ALI, AMINA ABUBAKAR (contact);WALJEE, AKBAR K

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Africa;African;Age;antenatal;Artificial Intelligence;Biological;cardiovascular disorder risk;care delivery;career;Caring;Child;Child Health;clinically relevant;Cohort Studies;commercialization;Communication;Communities;computational platform;computer science;Country;Coupled;Data;Data Analyses;Data Analytics;data ecosystem;data hub;data interoperability;data management;Data Science;Data Set;data sharing;Data Sources;Development;Developmental Delay Disorders;Disease;early childhood;Ecosystem;empowerment;Ensure;Environment;Event;FAIR principles;Feeling suicidal;Female of child bearing age;Fostering;Funding;Future;Future Generations;Government;Grant;Guidelines;Health;Health Personnel;Health system;Healthcare;high risk;High Risk Woman;Hospitals;improved;Individual;Informatics;Infrastructure;Kenya;Life;Low Birth Weight Infant;machine learning method;machine learning prediction;Maternal and Child Health;Maternal Health;Medical Research;Mental Depression;Mental Health;Methods;mHealth;Michigan;mobile application;mobile computing;Modeling;Moods;Mothers;multidisciplinary;multimodal data;neonatal health;novel;novel strategies;open data;Outcome;Pathway interactions;Pattern;Personal Satisfaction;Pilot Projects;Policies;Population;population health;predictive modeling;pregnancy hypertension;Pregnancy Outcome;Private Sector;programs;psychosocial;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Research Training;Resource-limited setting;Resources;Risk;risk prediction model;statistics;surveillance data;synergism;System;Technology;Training Programs;translational pipeline;Trust;United States National Institutes of Health;Universities;university student;wearable device;Woman;Work;young adult;Youth

PROJECT_TITLE: UZIMA-DS: UtiliZing health Information for Meaningful impact in  East Africa through Data Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-S(70)R]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hematology;Liver Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Porphyrias are rare disorders caused by deficiencies in heme biosynthesis pathway enzymes, and there are few effective medical therapies available. In this proposal, we will assess the mechanism by which inhibition of the Wnt/b-catenin signaling pathway provides protection from liver injury in a chemically-induced mouse model of porphyria, and whether b-catenin inhibition can prevent progression or provide protection in genetic mouse models of erythropoietic and acute intermittent porphyria.

PI_NAMEs: NEJAK-BOWEN, KARI N (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute;Acute Intermittent Porphyria;Address;Affect;Aminolevulinic Acid;Appearance;Autophagocytosis;beta catenin;Cell Physiology;Chemicals;ChIP-seq;chromatin immunoprecipitation;Clinical;clinically relevant;comparison control;Defect;Deferoxamine;Deposition;Diet;Disease;Disease Progression;drug metabolism;efficacy evaluation;enzyme biosynthesis;enzyme pathway;Enzymes;Erythropoietic Protoporphyria;Event;Extrahepatic;ferrochelatase;FRAP1 gene;functional improvement;Gene Expression;Genes;Genetic;Genetic Models;Glutamate-Ammonia Ligase;Glutamine;Heme;heme biosynthesis;Hemin;Hepatic Porphyrias;Hepatobiliary;Hepatocyte;Heterozygote;Human;Hydroxymethylbilane Synthase;Immunohistochemistry;improved;in silico;In Vitro;in vitro Assay;inhibitor;Injury;Intervention;Knock-out;Knockout Mice;Ligase;liquid chromatography mass spectrometry;Liver;liver injury;Measures;Medical;Metabolic Diseases;Modeling;mouse model;Mus;Mutant Strains Mice;novel;novel therapeutic intervention;Oxygenases;Palliative Care;Pathology;Pathway interactions;patient subsets;Patients;Phenobarbital;Phenotype;Porphobilinogen Synthase;Porphyrias;Porphyrins;prevent;Process;Production;promoter;protein aggregation;Protoporphyrins;Rare Diseases;Regulation;Reporter;Role;Severities;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Source;standard of care;Testing;Tetrapyrroles;Therapeutic;therapeutic development;Therapeutic Intervention;Time;Treatment Efficacy;Validation;Visualization;WNT Signaling Pathway;Work

PROJECT_TITLE: Beta-catenin inhibition as a novel therapeutic strategy for porphyria

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Cancer Health Activism Network for Greater Equity (CHANGE) aims to increase Black and African American K-12 student motivation and interest in biosciences and health careers by developing and disseminating novel high school biology lessons that focus on cancer biology and cancer disparities with a social justice lens. High school biology teachers will participate in research internships to study cancer fundamentals and will work with a team of experts to develop lesson plans that connect biology standards with cancer biology and disparities research. We hypothesize that aligning cancer research with the Transformative Leadership framework will create equitable learning experiences for Black and African American students, motivating them to pursue bioscience careers.

PI_NAMEs: NICHOL, CAROLYN AITKEN (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Academy;Address;Advocacy;Advocate;African American;African American population;African American student;anti-cancer research;Area;Asian population;Award;Bachelor's Degree;Basic Science;Bioethics Consultants;Biological;biological research;Biological Sciences;Biology;Black American;Black race;Caliber;Cancer Biology;cancer health disparity;cancer prevention;cancer therapy;career;career preparation;Cities;Collaborations;college;College Preparation;Communities;comparison control;Complex;curriculum development;data repository;Death Rate;Development;Development Plans;Disparity;diversity and inclusion;Education;Educational Curriculum;Educational process of instructing;Educational workshop;Equity;Ethnic Population;Evaluation;experience;Fortification;Funding;Goals;Health;health care disparity;Health Disparities Research;health disparity;health equity;high school;Hispanic Populations;Human Resources;improved;Individual;Inequality;Inequity;innovation;Institution;interest;Internships;Justice;K-12 Faculty;K-12 student;Knowledge;Leadership;Learning;learning materials;lens;Link;Location;Malignant Neoplasms;marginalization;marginalized community;marginalized population;Measures;Medical;Medical center;method development;Motivation;Next Generation Science Standards;novel;Outcome;outreach;pedagogy;Persons;Physicians;Policies;Preparation;Primary Schools;Process;programs;racial disparity;racial population;Research;Research Institute;Research Personnel;resilience;Rice;Role;school district;Schools;science teacher;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;Series;skills;social;Social Justice;Social Sciences;sociologist;student participation;Students;teacher;Teacher Professional Development;Texas;theories;Training;Trust;underrepresented minority student;United States National Institutes of Health;Universities;virtual;virtual health;Voice;Work

PROJECT_TITLE: Evaluation of Cancer Health Activism Network for Greater Equity (CHANGE)


ORG_CITY: UNIVERSITY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

PHR: Narrative: This project involves a research program at the University of Mississippi on the quality and safety of botanical ingredients used in the United States. The study results will provide essential information to support the US Food and Drug Administration's regulatory decisions regarding these products. The investigators will obtain authentic plants and reference materials, develop measurement and identification techniques for the components of quality and safety concerns, and provide these scientific tools to the FDA, industry, trade associations, and other stakeholders.

PI_NAMEs: KHAN, IKHLAS AHMAD (contact)

PROGRAM_OFFICER_NAME: NOONAN, GREGORY

PROJECT_TITLE: Science based authentication, validation & safety of botanical ingredients


ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE DEPT OF AGRIC/CONSUM SRVCS

PHR: Project Narrative Overall  Florida Department of Agriculture and Consumer Services (FDACS) Maintenance AFRPS w/Optional Coordinated PC Regulatory Activities PAR-20-132 Division of Agricultural Environmental Services (AES) Proposal to FDA for Participation in Development and Maintenance of the Animal Feed Regulatory Program Standards with Optional Coordinated Preventive Control Regulatory Activities and Capacity Building (U18) Clinical Trial Not Allowed The Florida Department of Agriculture and Consumer Services (FDACS) is requesting funding to enhance the infrastructure and effectiveness of Florida’s Feed Safety monitoring and enforcement programs through participation in Implementation of the Maintenance AFRPS w/Optional Coordinated PC Regulatory Activities PAR-20-132.

PI_NAMEs: HAYSLIP, GEORGE  (contact)

PROGRAM_OFFICER_NAME: CLARK, JACOB

PROJECT_TITLE: FDACS-Maintenance AFRPS w/Optional Coordinated PC Regulatory Activities


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The development and efficacy-testing of a holistic, personalized, electronically integrated clinical decision support system for left-ventricular assist device (LVAD) candidates will help to ensure that heart failure (HF) patients receive tailored treatments that lead to optimal and values-based outcomes. Our study applies the most advanced personalized risk prediction technologies and decision support available to make sure that evidence about cardiac outcomes is used by both patients and clinicians in the service of shared decision making that leads to more informed and value-concordant health decisions. The impact of this personalized approach to clinical decision making addresses the urgent need to better identify and respond to the specific and dynamic nature of patient needs in seeking treatment for advanced HF.

PI_NAMEs: BLUMENTHAL-BARBY, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: A multi-site trial to test benefits of adding a personalized risk calculator to an online decision aid for left ventricular assist device

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Cognitive behavioral therapy involving exposure and ritual prevention (EX/RP) is a first-line treatment for obsessive compulsive disorder (OCD), yet EX/RP leads to more variable responses in women than in men. Studies show that the hormone estrogen affects the brain’s fear extinction network, and the functioning of this network predicts response to EX/RP. This study will examine whether delivering EX/RP to women during the time in their menstrual period when estrogen is high affects the fear extinction network and leads to better outcome, with the long-term goal of optimizing and personalizing treatments for individuals suffering from OCD.

PI_NAMEs: FOA, EDNA B (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Acceleration;Adult;Affect;Aftercare;Amygdaloid structure;Anterior;Anxiety;Biological Assay;Blood;blood oxygen level dependent;Brain;Brain region;cingulate cortex;Clinical;Cognitive Therapy;conditioned fear;Data;design;Dorsal;Elements;Ensure;Estrogens;Exhibits;Exposure to;Extinction;follow-up;Fright;Functional Magnetic Resonance Imaging;functional MRI scan;Goals;Gonadal Hormones;Hippocampus;Hormonal;Hormones;Human;Image;improved;indexing;Individual;Induced Neurons;Knowledge;Lead;Learning;learning extinction;Luteal Phase;Manuals;Measures;Mediating;memory retention;men;Menstrual cycle;Menstruation;neural;neuromechanism;New York;Obsessive-Compulsive Disorder;Outcome;outcome prediction;Participant;Patients;Pennsylvania;personalized medicine;Phase;predicting response;Prefrontal Cortex;Prevention;Prevention Protocols;Process;proliferative phase Menstrual cycle;Protocols documentation;Randomized;Recommendation;recruit;reduce symptoms;Research;response;Rest;Ritual compulsion;Rodent;Sample Size;Sampling;Scanning;severe mental illness;Severities;sex;sex as a biological variable;sex cycle;Sex Differences;Signal Transduction;Site;Structure;Symptoms;Testing;Time;tool;Treatment outcome;Treatment Protocols;Universities;Variant;Woman;women's outcomes

PROJECT_TITLE: 2/2 Harnessing Hormonal Variation to Probe Neural Mechanisms and Optimize CBT Outcomes for OCD

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative The brain first becomes active during development, before it can receive signals from any of our senses, and we do not fully understand how this activity affects the maturation of connections between nerve cells. We will use the fruit fly, which has a much simpler brain but offers much greater experimental control, to study how this activity during development comes about and how it controls the organization of nerve cell connections. Answering these fundamental questions about brain development in the fruit fly may lead to insights into the origins of neurodevelopmental diseases.

PI_NAMEs: AKIN, ORKUN  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Patterned, Stimulus-Independent Neuronal Activity In the Developing Drosophila Visual System: Origin and Contribution to Synaptic Maturation

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]