NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention

PHR: NARRATIVE In our state of Alabama, there is a need to encourage medical, dental and master-level graduate students to pursue careers that will facilitate an improved understanding of cancer biology, etiology, pathogenesis of primary and secondary cancers and outcomes, develop innovative interventions for early detection and modifiable risk factors, as well as develop novel therapeutics to promote the greatest impact in the state. The Enhancing Research in Cancer-related Health professions (ENRICH) Program is an innovative 10-week summer program that will provide structured and thoughtfully-crafted opportunities for 30 medical, dental, and master-level graduate students from a diverse spectrum of disciplines including public health, basic science, health professions, nursing, and pharmacy from UAB and Samford University. ENRICH alumni will be well- positioned to pursue additional training in their selected research-intensive pursuits leading to cancer-focused careers in academia, industry, government, non-profit organizations, or other health systems and meet the emerging needs of cancer research.

PI_NAMEs: BROWN, ELIZABETH E;SHEVDE, LALITA A. (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Academia;Academy;Alabama;anti-cancer research;Area;Basic Science;Cancer Biology;cancer care;Cancer Control;career;career development;Clinical;clinical center;Clinical Research;Clinical Sciences;Communication;Communities;Competence;Complement;Comprehensive Cancer Center;Creativeness;Curiosities;Dental;design;Development;Discipline;Discipline of Nursing;dissemination science;Early Diagnosis;Early Intervention;Educational workshop;Effectiveness;empowerment;Environment;Epidemiology;Etiology;Evaluation;experience;Exposure to;faculty mentor;Fostering;Generations;Goals;Government;graduate student;Health Occupations;Health system;implementation science;improved;Individual;Industry;Infrastructure;innovation;innovative technologies;interest;Investigational Therapies;Knowledge;Learning;Malignant Neoplasms;Medical;Mentors;Methods;modifiable risk;multidisciplinary;neuro-oncology;next generation;Nonprofit Organizations;novel strategies;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Persons;Pharmacy facility;Pharmacy Schools;Physicians;Population Sciences;Positioning Attribute;Process;programs;Public Health;public health research;Reproducibility;Research;Research Ethics;Research Personnel;Resources;Risk Factors;Science;Scientist;Second Primary Cancers;secondary outcome;skills;Standardization;Structure;Students;study population;summer program;summer research;Surveys;tool;Training;Training and Education;translational framework;Translational Research;tumor immunology;Universities

PROJECT_TITLE: The UAB-ENhancing Research In Cancer-related Health professions (ENRICH) Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: FD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: LANSING

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MICHIGAN STATE DEPT OF AGRICULTURE

ORG_STATE: MI

PHR: The Michigan Department of Agriculture and Rural Development (MDARD) intends use this funding opportunity to support activities to meet regulatory requirements, and improve the laboratory's overall efficacy, accuracy, and defensibility on a continuous basis and to maintain and enhance our current level of services with MDARD's federal, state, and local partners. It allows for the risk-based development of performance metrics to base MDARD's laboratory division future objectives upon, allowing MDARD to better forecast potential emerging issues and hazard. This funding will allow MDARD to work with our regulatory partners to develop plans and processes to facilitate the increase sample volumes across our human and animal food microbiology and chemistry sections to work with our regulatory partners in the process of increasing the types of analysis across the two section by allowing for new advanced technologies and methodologies to be explored such as Whole Genome Sequencing, allergens, food adulteration, toxic elements, and economic fraud. The lab will maintain its ISO 17025 accreditation providing confidence and defensibility in the labs results. MDARD will continue to work with the Emergency Rapids Response Team and the MDARD Food and Dairy Division and FDA to build a more robust and effective food defense program.

PI_NAMEs: POLASKEY, JORDAN  (contact)

PROGRAM_OFFICER_NAME: LI, MEI-YING

PROJECT_TITLE: Laboratory Flexible Funding Model (LFFM) (U19) Clinical Trials Not Allowed


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE This T32 predoctoral training program will create a cadre of scholars with commanding knowledge and experiences across the translational spectrum as well as a deep commitment to transdisciplinary team science. Scholars will receive a breadth of training as well as holistic and diverse mentoring. This will ensure that they have the knowledge and ability to communicate across boundaries and thereby increasing transdisciplinary cross-fertilization and accelerating healthcare advances.

PI_NAMEs: FAGERLIN, ANGELA ;FAIRFAX, KEKE CELESTE (contact)

PROGRAM_OFFICER_NAME: DIBELLO, ANTHONY THOMAS

PROJECT_TITLE: CTSA Predoctoral T32 at University of Utah: Spheres of Translation Across the Research Spectrum (STARS) Training Program


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Emergency Care;Nutrition;Obesity;Prevention;Sleep Research

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: NARRATIVE Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable. This project will examine whether avoiding food intake during the biological night can mitigate the impact of circadian misalignment on metabolic homeostasis in adults during simulated night shift work. Findings from this study could identify a translatable strategy to minimize metabolic diseases in populations that include anyone working nonstandard hours such as police, paramedics, firefighters, military personnel, pilots, doctors and nurses, truck drivers, and individuals with sleep disorders.

PI_NAMEs: BROUSSARD, JOSIANE  (contact)

PROGRAM_OFFICER_NAME: SILVA, CORINNE M

PROJECT_TERMS: Abdomen;Achievement;Acute;Adult;Attenuated;awake;Behavior;Behavioral;Biological;Biopsy;Blood specimen;Chronic Disease;circadian;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;clinically relevant;combat;Consumption;cost effective;Cross-Over Studies;Data;Development;Diabetes Mellitus;diabetes risk;Diet;Disease Management;disorder prevention;disorder risk;Eating;emergency service responder;Employee;Energy Intake;Environmental Risk Factor;experience;Fatty acid glycerol esters;fatty acid metabolism;fire fighter;Gene Expression;Genes;Glucose;Glucose Clamp;Glycolysis;Goals;Healthcare;Homeostasis;Hour;Hyperinsulinism;Impairment;improved;in vivo;Individual;Inpatients;Insulin Resistance;insulin sensitivity;Intervention;intrahepatic;Jet Lag Syndrome;Knowledge;Laboratories;Light;Link;Lipids;Medical;Medical Residency;men;Metabolic;Metabolic Diseases;Military Personnel;Modernization;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;novel;Nurses;obesity development;obesity risk;Paramedical Personnel;Persons;Physiology;Pilot Projects;Plasma;Police;Population;Populations at Risk;prevent;programs;Protocols documentation;Quantitative Reverse Transcriptase PCR;Randomized;Risk;Risk Factors;risk mitigation;Rotation;Sampling;Savings;Schedule;shift work;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Societies;System;Testing;Time;Time-restricted feeding;transcriptome sequencing;translatable strategy;Weight Gain;Woman;Work

PROJECT_TITLE: Time-restricted feeding to mitigate metabolic impairments during circadian misalignment

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: Nashville

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE SF3B1 is the most commonly mutated splicing factor in cancer, so identifying resultant therapeutic vulnerabilities can significantly impact the many cancers harboring these mutations (breast, melanoma, pancreatic, bladder, etc.). Development and use of novel genetic models of SF3B1 will allow us to delineate its mutation-specific roles in tumorigenesis and define potential therapeutic strategies. Additionally, key mechanistic insight will be gained from the observation that TP53 and SF3B1 mutations are mutually exclusive in cancer and therefore are likely to have overlapping roles in tumorigenesis.

PI_NAMEs: BERGMAN, RILEY  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acute Myelocytic Leukemia;Biological Models;Biological Process;Bladder;Breast;Breast Melanoma;Cancer Patient;cancer type;career;Cell Line;Cell model;Cell Reprogramming;Cell Respiration;cell type;Characteristics;Clinical;Core Facility;CRISPR/Cas technology;Cutaneous Melanoma;Data;Databases;Dependence;Development;Electron Transport Complex III;Ensure;Evaluation;Event;Foundations;Future;Generations;Genes;Genetic Models;genome editing;Genus Hippocampus;Glucose;Human;Impairment;improved;Incidence;Individual;innovation;insight;Invaded;Knock-in;Knock-out;Lead;leukemia;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;Melanoma;Melanoma Cell;Metabolic;Metabolic Pathway;metabolomics;migration;Mitochondria;Modeling;Molecular;Molecular Genetics;mutant;Mutate;Mutation;novel;Oncogenes;Oncogenic;Oncology;Outcome;Pancreas;Pathologic;Pathway interactions;personalized strategies;Phenotype;Production;Prognosis;Proliferating;Property;Proteins;Public Health;Publishing;Recording of previous events;Resources;Respiration;RNA;RNA Splicing;Role;Series;Site;Solid;Solid Neoplasm;Technical Expertise;Testing;Therapeutic;therapeutic target;Tissues;TP53 gene;Transcript;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;tumor;Tumor Cell Line;Tumor Subtype;tumorigenesis;tumorigenic;Tumorigenicity;Universities;Warburg Effect;Work

PROJECT_TITLE: Harnessing hotspot specific differences among SF3B1 mutations to define novel mechanisms of tumorigenicity and targetability in solid malignancies


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Drug Abuse (NIDA only);Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This mixed-methods project will analyze Medicaid and commercial insurance datasets, along with in-depth interviews of key stakeholders and pregnant women who use opioids, to identify how states’ prenatal-specific opioid policies (e.g., preferential access to opioid treatment for pregnant women), general opioid policies (e.g., naloxone, Good Samaritan Laws), and states’ overall opioid policy climates impact opioid-related outcomes among pregnant and postpartum women and their newborns. This project will be the first US-based study to systematically map the impact and implementation of separate state opioid policies and overall state opioid climates on pregnant women and their newborns. Data from this study will address a National Institute on Drug Abuse (NIDA) priority and identify critical intervention points and policy changes that will promote maternal and infant wellbeing.

PI_NAMEs: MARTINS, SILVIA SABOIA (contact);PHILBIN, MORGAN MARI

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Affect;Age;Categories;Charge;Child Abuse;Child Care;child neglect;Chronic;Climate;climate impact;cohort;Communities;Consolidated Framework for Implementation Research;Data;Data Set;Databases;design;Disproportionately impacts women;Ethnic Origin;Ethnography;Face;Factor Analysis;Female of child bearing age;Health;Health Promotion;Hospitals;Individual;Infant;Insurance;insurance claims;Intervention;Interview;Knowledge;Laws;Life;Maps;Maternal Health;maternal opioid use;Medicaid;Medical;medication for opioid use disorder;Methods;Modification;Morbidity - disease rate;mortality;Naloxone;National Institute of Drug Abuse;Neonatal Abstinence Syndrome;neonatal health;Newborn Infant;Opioid;opioid misuse;opioid policy;opioid use;opioid use disorder;opioid use in pregnancy;Outcome;Overdose;Pathway interactions;Pattern;Personal Satisfaction;Policies;Population;Postnatal Care;Postpartum Women;Pregnancy;Pregnant Women;prenatal;Prenatal care;prescription opioid;Privatization;Provider;Race;Reporting;Research;response;Risk;Services;social stigma;Strategic Planning;substance use;Surveys;System;Taxonomy;Testing;Time;United States;Variant;Woman

PROJECT_TITLE: State-level opioid policies and policies that regulate substance use duringpregnancy: a mixed methods exploration of their effects on maternal and infantoutcomes

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Lung;Lung Cancer

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Tumor recurrence after treatment is a major contributor to mortality from cancer. Recurrence is mediated by a distinct, treatment-resistant subpopulation of cells within a tumor that can regenerate the tumor after treatment. The proposed research aims understand the cellular mechanisms that promote formation and maintenance of these tumor-initiating cells, and develop a strategy to selectively target them.

PI_NAMEs: VIEIRA, HEIDI  (contact)

PROJECT_TERMS: Affect;Aftercare;Anchorage-Independent Growth;Binding;Biological Assay;cancer cell;Cancer cell line;Cancer Patient;cell growth;Cell Physiology;Cells;Characteristics;Clinical;clinical efficacy;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;Colorectal Neoplasms;combat;CRISPR/Cas technology;Data;Dependence;Development;Drug Efflux;Drug resistance;Engineering;Frequencies;Goals;Impairment;In Vitro;in vivo;inhibitor;Knock-out;KSR gene;lung cancer cell;Lung Neoplasms;Maintenance;Malignant Neoplasms;Mediating;MEK inhibition;MEKs;Metabolic;Modality;Modeling;Molecular;mortality;Mus;mutant;Mutate;Mutation;Natural regeneration;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Population;pre-clinical;Pre-Clinical Model;prevent;Process;Property;Protac;protein degradation;RAS driven cancer;RAS driven tumor;Recurrence;Recurrent tumor;Regulation;Research;Resistance;Resistance development;Role;RSU1 gene;scaffold;self-renewal;Signal Pathway;Signal Transduction;Solid Neoplasm;stemness;System;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapeutic target;Transgenes;tumor;tumor ablation;Tumor Cell Line;Tumor Expansion;tumor initiation;Tumor Promotion;tumorigenic

PROJECT_TITLE: Molecular control of tumor-initiating cells in Ras-driven cancers


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: The proposed research is relevant to public health because understanding of the basic biological function of heparan sulfate–cathepsin K interaction is ultimately expected to provide novel therapeutic solutions to treat many diseases associated with undesired bone resorption. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to reduce illness and enhance health.

PI_NAMEs: LIU, JIAN ;XU, DING  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Affect;Affinity;Binding;Binding Sites;Biochemical;Biological;Biological Process;Biology;Biophysics;bone;Bone Diseases;Bone Matrix;Bone remodeling;Bone Resorption;cardiovascular disorder risk;cathepsin K;Cell surface;Charge;Chondroitin Sulfates;Collagen Type I;collagenase;Complex;Crystallization;Data;design;Disease;drug development;Drug Targeting;Evaluation;Extracellular Matrix;Foundations;fracture risk;Future;Glycosaminoglycans;Goals;Health;Heparitin Sulfate;Heterozygote;In Vitro;in vivo;inhibitor;insight;Investigation;Knock-in Mouse;Knockout Mice;Knowledge;Lead;Mammalian Cell;Marketing;Methods;Mission;mouse model;Mouse Strains;Mus;Mutate;novel;novel therapeutics;Oligosaccharides;Osteoclasts;Osteoporosis;Osteoporotic;Outcome;Paget's Disease;Peptide Hydrolases;Peptides;Periodontitis;Pharmaceutical Preparations;Phase III Clinical Trials;Phenotype;Physiological;Pilot Projects;Play;Postmenopause;prevent;Property;Proteins;Public Health;Recombinants;Reporting;Research;Rheumatoid Arthritis;Roentgen Rays;Role;side effect;Site-Directed Mutagenesis;Solid;stoichiometry;Structure;Testing;Therapeutic;United States National Institutes of Health;Woman;X-Ray Crystallography;Yeasts

PROJECT_TITLE: The role of heparan sulfate in cathepsin K biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cancer;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: HONOLULU

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE This project will develop a “smart” needle for accurate and less invasive radioactive seed implantation in prostate brachytherapy. Analytical and computational models, with model parameter updates, will be developed based on realistic tissue properties to have a better understanding of needle-tissue interaction mechanism. The smart needle will be integrated with a teleoperated user control interface, with better understanding of the dynamics of the system and shape- and force- sensing, to improve needle guidance into a desire path towards the target, and thereby improved clinical outcomes.

PI_NAMEs: KONH, BARDIA  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;3D Print;Adoption;Algorithms;Biopsy;Bladder;Brachytherapy;Cadaver;Calibration;Cancer Intervention;Cancerous;Cells;Characteristics;Clinical;Collaborations;Compensation;Computer Models;cost;design;Development;Devices;Diagnosis;Dislocations;dosage;Dose;Drug Delivery Systems;dynamic system;Dysuria;Edema;Effectiveness;Electromagnetics;Endowment;Exclusion;experience;eye hand coordination;fabrication;Feedback;flexibility;gene therapy;Goals;Healthcare;Human;human error;Imaging Device;Implant;improved;in vivo evaluation;Incontinence;innovation;instrument;instrumentation;Intelligence;Intuition;kinematics;Location;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;manufacture;Mechanics;Methods;minimally invasive;Modality;Modeling;Modernization;Motion;Movement;Needles;novel;Operative Surgical Procedures;Organ;Outcome;Pain;Patients;Performance;Physicians;Positioning Attribute;predictive modeling;Procedures;Property;Prostate;PUVA Photochemotherapy;Radiation;Radioactive;Radioactive Seed Implantation;Raman Spectrum Analysis;Rectum;Reporting;Research;Resected;response;Robot;robot control;robotic system;Robotics;Seed Implantation;sensor;Shapes;side effect;skills;Source;Structure;success;Surgeon;System;Techniques;teleoperation;Therapeutic Intervention;Therapeutic procedure;Thermal Ablation Therapy;Tissue Model;Tissues;Toxic effect;Translating;Treatment Failure;trend;Ulcer;ultrasound;Uncertainty;Update;Urethra;urinary;Urination;Viral;Work

PROJECT_TITLE: Smart Needle with Intelligent Robotic Control for Prostate Brachytherapy


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Tobacco

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Prenatal exposure to nicotine causes an increased incidence of auditory processing disorders in children and an increased risk of hearing loss across lifespan, and the growing use of e-cigarettes over traditional cigarettes emphasizes the need for more research investigating the effect of nicotine alone on the brain development and function. The proposed study will evaluate the effect of perinatal nicotine exposure on the auditory brainstem, the first brain region to receive sound information from the cochlea. These findings will provide insight into synaptic signaling dysfunction via perinatal nicotine exposure on brainstem physiology and sensory function.

PI_NAMEs: WOLLET, MACKENNA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Acute;Adult;Affect;Animal Model;Auditory;Auditory area;Auditory Brainstem Responses;Auditory Perceptual Disorders;auditory processing;Auditory system;Binaural;Birth;Brain;Brain region;Brain Stem;Cell Nucleus;Central Auditory Processing Disorder;Child;cholinergic;Chronic;Cigarette;cigarette smoking;Cochlea;combustible cigarette;critical period;Detection;Development;Dyes;Electric Capacitance;Electronic cigarette;electronic cigarette use;Electrophysiology (science);Equilibrium;experience;exposure to cigarette smoke;Feedback;Fiber;Functional disorder;Future;Glutamate Receptor;glutamatergic signaling;Glutamates;Hearing;hearing loss risk;Hearing problem;Hearing Tests;Hippocampus;Human Development;Immunohistochemistry;Impairment;in vivo;Incidence;Individual;Infant;insight;life span;Location;Measures;Medial;Mediating;Modeling;Mus;neural;Neurons;Nicotine;nicotine exposure;Nicotinic Receptors;Noise;otoacoustic emission;patch clamp;Perinatal;Perinatal Exposure;Peripheral;Phenotype;Physiology;postnatal;postnatal development;postsynaptic;prenatal;prenatal exposure;prenatal nicotine exposure;presynaptic;Presynaptic Terminals;Process;Rattus;receptor expression;reconstruction;Reporting;Research;response;Risk;Rodent;Role;Sensory;Sensory impairment;Signal Transduction;Smoker;smoking during pregnancy;sound;Sound Localization;Structure;Sudden infant death syndrome;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;transmission process;trapezoid body;Up-Regulation;Visualization;Western Blotting;Whole-Cell Recordings;Work

PROJECT_TITLE: Consequences of Perinatal Nicotine Exposure on Functional Brainstem Development


ORG_NAME: HAWAII STATE DEPT OF AGRICULTURE

PHR: Hawaii Produce Safety Program PAR-21-174: The FDA's Cooperative Agreement Program for States and Territories to Implement a  National Produce Safety Program  Project Period: July 1, 2022 - June 30, 2026  Project Narrative This project is a continuation of our mission to educate growers about the Produce Safety Rule, and to prepare growers for our regulatory inspection activities intended to protect public health. In Project Years 1 and 2, our Program will continue along PATH A, to advance its Produce Safety Rule related education, outreach, and technical assistance activities for Hawaii covered produce growers. A transition into PATH B, will begin in Year 3, with a start date of July 1, 2024, where the Program will implement its plan to conduct produce safety inspections under FDA’s authority, and execute procedures that align with FDA’s Standardized Approach to Produce Farm Inspections.

PI_NAMEs: OBALDO, LEONARD G (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, ANDREA

PROJECT_TITLE: Implementation of FDA Produce Safety Rule in Hawaii


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Oncologists need better tools for assessing patient tumors on a case-by case basis during treatment planning. We propose to develop robust technology that will allow scientists to study cancer biology or perform drug testing on clinically-relevant samples. The technology will provide the urgently needed tools for cancer research and for personalized assessment of treatment response so that the most effective treatment can be applied to each patient.

PI_NAMEs: DUDA, DAN GABRIEL;MUNN, LANCE L. (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acceleration;Address;Adjuvant;Adjuvant Therapy;Anatomy;anti-cancer research;Apoptosis;Assessment tool;Biological;Biological Assay;Biology;Blood Vessels;Cancer Biology;Cancer Center;case-by-case basis;Cell Proliferation;Cells;Chemoresistance;chemotherapy;Clinical;clinically relevant;Coculture Techniques;Collagen;Combined Modality Therapy;Cultured Tumor Cells;cytotoxic;density;Diagnosis;Disease;Drug Screening;drug testing;Drug usage;effective therapy;Engineering;Excision;experimental study;Extracellular Matrix;Fibroblasts;Fibronectins;Fluorouracil;gemcitabine;Growth;Harvest;high throughput screening;Histologic;Human;Hyaluronan;Immunodeficient Mouse;Implant;improved;In Vitro;in vivo;Investigational Therapies;irinotecan;Leucovorin;Localized Disease;Maintenance;Malignant Neoplasms;Methodology;Mus;Neoplasm Metastasis;novel strategies;Oncologist;Operative Surgical Procedures;oxaliplatin;Oxygen;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Patients;Perioperative;personalized cancer therapy;Pharmaceutical Preparations;Population;Postoperative Period;predictive tools;preservation;prevent;Primary Neoplasm;Probability;Proliferating;prospective;Protocols documentation;Recurrence;Regimen;Resected;response;Rest;Sampling;Scientist;second harmonic generation imaging;self assembly;single-cell RNA sequencing;Specimen;spheroids;standard care;standard of care;Stromal Cells;success;System;Technology;Testing;Time;Tissue Sample;Tissues;tool;treatment duration;treatment planning;treatment response;tumor;Tumor Biology;tumor growth;tumor progression;Tumor Tissue;Tumor-associated macrophages;vascular bed;Vascularization;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Vascularized tumor explants for drug testing

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: MEMPHIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MEMPHIS

PHR: Project Narrative Expanding evidence suggests that pharmaceutically targeting the oxytocin system could provide a critical advancement in the treatment of substance use disorder. Oxytocin administration has been shown to decrease the reinforcing effects of drugs while increasing the salience of social stimuli. The proposed study aims to determine the effects of oxytocin receptor activation on reward-related neural circuitry, providing a crucial step for harnessing the full therapeutical potential of oxytocin for substance use disorder.

PI_NAMEs: LESTER, DERANDA B (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: addiction;Adult;Affect;Agonist;Anesthesia procedures;Attenuated;Autoreceptors;behavioral response;biological adaptation to stress;Brain region;Cell Nucleus;Cells;Clinical;Clinical Trials;Complex;Detection;Diagnosis;Dopamine;Dopamine D2 Receptor;Dopaminergic Cell;dopaminergic neuron;Dose;drug abstinence;drug reward;Drug usage;Electrodes;experience;FDA approved;Female;Fire - disasters;Future;Gender;improved;in vivo;Infusion procedures;Location;male;Mediating;meetings;mesolimbic system;Mus;neural;neural circuit;neurochemistry;Neuropeptides;novel;Nucleus Accumbens;Outcome;Oxytocin;Oxytocin Receptor;Pathway interactions;Patients;Pattern;Periodicity;Peripheral;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Process;programs;psychostimulant;Receptor Activation;Recovery;Relapse;Research;response;reward processing;Rewards;Scanning;sex;Site;social;Social Behavior;Socialization;stimulant use disorder;Stimulus;Structure;Substance Use Disorder;substance use treatment;System;Techniques;Therapeutic;Therapeutic Effect;Treatment outcome;Ventral Tegmental Area

PROJECT_TITLE: Oxytocin Mediates Phasic and Tonic Dopamine Release


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE No effective pharmacological or medical device interventions are available to treat heart failure with preserved ejection fraction (HFpEF), but exosomes from cardiosphere-derived cells (CDCEXO) are therapeutic. Here we seek to establish detailed molecular signatures of HFpEF; to use those molecular signatures as roadmaps to identify key, potentially causal pathways by dissecting the responses to CDCEXO; and to discover novel defined molecular entities within the CDCEXO that underlie disease-modifying bioactivity in HFpEF. This will allow us todefine specific RNA species or proteins that may be preferable to complex biologicals (cells, exosomes) in terms of mechanistic discreteness, ease of manufacturing, and therapeutic consistency.

PI_NAMEs: MARBAN, EDUARDO ;VAN EYK, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;Arrhythmia;Benchmarking;Biopsy;Biopsy Specimen;cardioprotection;Cell Therapy;Cells;Chemicals;Collagen;comorbidity;comparative efficacy;Complex;Control Groups;cost;Data;design;Disease;disease phenotype;EFRAC;exosome;Exposure to;extracellular vesicles;Family suidae;Fibrosis;FRAP1 gene;Genetic Transcription;Goals;Heart;Heart Abnormalities;Heart Diseases;Heart failure;Histologic;Human;improved;in vivo;Inflammation;Intervention;manufacture;mechanical properties;Mediating;Medical Device;Methods;MicroRNAs;Mining;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial;new chemical entity;novel;novel strategies;novel therapeutics;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;porcine model;Post-Translational Protein Processing;preservation;Proteins;Proteome;Proteomics;Rattus;Reporting;response;RNA;Rodent;single-cell RNA sequencing;Sorting;targeted treatment;Techniques;Testing;Therapeutic;therapeutic candidate;Tissues;transcriptome sequencing;transcriptomics;Translations;Treatment Efficacy;treatment response;Untranslated RNA;Ventricular

PROJECT_TITLE: Exosome Therapeutics to Dissect HFpEF Mechanisms

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: DENVER

ORG_NAME: COLORADO STATE DEPT/PUB HLTH & ENVIRONMT

PHR: LFFM Overall Narrative The CDPHE laboratory is eager to participate in the FDA Laboratory Flexible Funding Model program in order to support microbiological and chemical testing of food products in Colorado. Participation in the program will allow continued surveillance for contamination of food products as well as expand needed WGS testing to these commodity types and demonstrate capability to respond to contamination with high consequence pathogens.

PI_NAMEs: TRAVANTY, EMILY ANNE (contact)

PROJECT_TITLE: Laboratory Flexible Funding Model for Food Defense and Human Food Testing - Colorado


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE While significant research efforts have been devoted to determining the biological pathways of cognition and emotion, there is concern over the lack of reproducibility of findings. This proposal seeks to develop and apply a Network Level Analysis (NLA) toolbox which will be used to identify and characterize the brain networks underlying healthy and disordered development of executive and emotional processes. The NLA toolbox is a versatile analysis pipeline which leverages the structural and functional architecture of the brain and rigorous statistical testing and validation procedures to define brain-behavior relationships across species, across the lifespan, and in health and disease.

PI_NAMEs: WHEELOCK, MURIAH D (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Acceleration;Adolescent;Adult;Advisory Committees;Age;analysis pipeline;analytical method;analytical tool;Architecture;Area;Award;Behavior;Behavior assessment;behavior measurement;Behavioral;Biological;Biometry;Brain;brain behavior;BRAIN initiative;Brain Mapping;Brain region;Career Transition Award;Cloud Computing;Cognition;Cognitive;cognitive development;cognitive reappraisal;cohort;Complex;computer science;connectome;connectome data;Data;Data Analyses;Data Set;Development;Diffusion Magnetic Resonance Imaging;dimensional analysis;Discipline;Disease;Documentation;emotion regulation;Emotional;emotional functioning;Emotions;Endocrine;Ensure;executive function;Family;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;graphical user interface;Health;Human;Human Development;improved;in silico;in vivo;indexing;innovation;Intervention;Investigation;life span;Link;longitudinal dataset;longitudinal design;Machine Learning;Manuals;Maps;Measures;Mental Processes;Mentors;Mentorship;Methods;Modeling;network architecture;neuroimaging;Neurosciences;Pathway interactions;Perception;Performance;Phase;post intervention;Procedures;Process;Production;programs;Psychopathology;Publishing;Reaction Time;Reproducibility;Reproducibility of Results;Research;Research Personnel;ROC Curve;Scanning;Scientist;Sensitivity and Specificity;skills;software development;Software Engineering;Statistical Data Interpretation;Structure;success;Symptoms;Techniques;Testing;tool;tool development;Training;United States National Institutes of Health;Update;Validation;Writing;young adult

PROJECT_TITLE: Innovative biostatistical approaches to network level analyses of connectome-behavior relationships


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: EAST LANSING

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE (Population Health Statement) (3 sentences) This application proposes to create a pipeline of underrepresented and disadvantaged addiction researchers to increase the available workforce of practitioners who have research-based training in substance use disorders to bring a broader diversity to the clinician-science workforce. This program will provide education on the clinical, social, and basic sciences underlying substance use disorders and support student research with NIH-funded researchers. The program's goal is to develop a "pipeline" of underrepresented and disadvantaged doctorate prepared nurses and physicians equipped to work in multidisciplinary research teams to provide evidence-based care for substance use disorders and hasten the translation and development of substance use disorder research.

PI_NAMEs: GOLDSTEIN, DAWN M;POLAND, CARA  (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Admission activity;Advanced Practice Nurse;Affect;Basic Science;Behavioral;Behavioral Sciences;career;career development;Caring;Clinical;Clinical Nurse Specialists;Clinical Research;Clinical Sciences;Collaborations;Development;Disadvantaged;disadvantaged background;disadvantaged student;Discipline of Nursing;Disparity population;Education;Educational Curriculum;Educational Status;Enrollment;Equity;evidence base;experience;Exposure to;Faculty;Funding;Future;Goals;Health system;Healthcare;improved;Interdisciplinary Study;Literature;Medical;Medical Students;Medicine;member;Mentors;Michigan;Minority;Modeling;Nurses;Nursing Schools;Nursing Students;Opioid;outreach;outreach program;Paper;Patients;Performance;Physicians;Population;population health;Prevention;Principal Investigator;Process;programs;Provider;Publications;Qualifying;recruit;Recruitment Activity;Registered nurse;Research;Research Personnel;Research Project Grants;Research Training;Science;science education;Scientist;Self Efficacy;simulation;skills;Social Sciences;social stigma;student participation;Students;substance use;Substance Use Disorder;Training;Training and Education;Training Programs;Translations;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;University resources;virtual;Work

PROJECT_TITLE: Increasing Minority Physician and APRN Clinician-scientist Research Training To Equalize Addiction Medicine (IMPACT TEAM)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative In this project, we utilize cutting edge proteomics and custom-designed functional screens to identify novel RNA binding proteins important for hematopoietic stem cells (HSC) fate, and characterize their targets by enhanced CLIP-seq and other genomics methods. If successful, these insights will provide fundamental insights into regulation of hematopoiesis, supporting translational research in leukemia and other diseases of the hematopoietic system.

PI_NAMEs: HOPE, KRISTIN ;YEO, EUGENE WEI-MING (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Binding;Binding Sites;Biological Assay;Cell Count;Cells;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complement;Core Protein;CRISPR screen;crosslinking and immunoprecipitation sequencing;Custom;Cytoplasmic Structures;Death Rate;Dependence;design;Diagnosis;Disease;Dropout;druggable target;effective therapy;engineered stem cells;Engraftment;G3BP1 gene;Gene Expression;Genetic Screening;genome-wide;Genomics;Growth;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;Hematopoietic stem cells;Hematopoietic System;Image;In Vitro;in vivo;insight;Kinetics;Knock-out;leukemia;leukemia relapse;leukemic stem cell;Malignant - descriptor;Maps;Measures;Mediating;Membrane;Messenger RNA;Methodology;Methods;MLL-rearranged leukemia;Mutation;Nature;new therapeutic target;novel;Pathogenesis;Pathology;Phenotype;Play;Polyadenylation;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;preservation;programs;Proliferating;Property;protein function;Proteins;Proteomics;Refractory;Refractory Disease;Regulation;Regulatory Pathway;Relapse;Research;Resistance;response;RNA;RNA metabolism;RNA Splicing;RNA-Binding Proteins;Role;Sampling;screening;Series;Spliced Genes;standard of care;stem cell function;stem cells;Stress;stress granule;Subgroup;technological innovation;therapeutic target;Time;Translational Research;Translations;Validation;Work

PROJECT_TITLE: Dissecting stress granule dependencies in leukemia stem cells

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Improved understanding of the mechanisms of neuroblastoma metastasis will require studies in an experimental system that faithfully recapitulates all stages of tumor metastasis in vivo while accommodating neuroblastoma-relevant genetic alterations identified from integrative genomic analyses. By establishing the mechanisms that underlie cooperation between low levels of GAS7 expression and MYCN overexpression in neuroblastoma metastasis, our proposed studies will advance knowledge of the factors that contribute to early dissemination of MYCN-driven neuroblastoma, leading in turn to identification of novel molecular targets for improved treatment of this devastating childhood disease.

PI_NAMEs: ZHU, SHIZHEN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: 17p;17p13.1;Acceleration;Accounting;Adaptor Signaling Protein;Adhesions;age group;Age Months;Animal Model;Attenuated;Binding;Biochemical;Bioinformatics;Biological Assay;Biology;bone;Bone Marrow;Cell membrane;Cells;Cephalic;Cessation of life;chemotherapy;Childhood;Chromosomes;Clinical;Complex;Complication;Coupled;Data;Data Set;Development;Diagnosis;Disease;Dissociation;Distant;Doxycycline;effective therapy;Emerging Technologies;Family;Fishes;Frequencies;GAS7 gene;Gene Expression;Gene Modified;gene repression;Genes;Genetic Transcription;genome sequencing;Genomics;Goals;Growth;Hematogenous;Heterozygote;high risk;Human;Immunoprecipitation;improved;in vivo;innovation;insight;Invaded;Knock-out;Knowledge;Link;Liver;loss of function;Loss of Heterozygosity;Luciferases;lymph nodes;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;member;metastatic process;Methylation;migration;Modeling;Molecular;Molecular Target;Motility;mouse model;Mus;Mutation;MYCN gene;N-Myc Protein;Neoplasm Metastasis;neoplastic cell;neuroblast;Neuroblastoma;Neuronal Differentiation;Non-Malignant;novel;novel therapeutics;Ocular orbit;Oncogenes;Outcome;overexpression;Pathogenesis;patient subsets;Patients;Pediatric Neoplasm;Positioning Attribute;Primary Neoplasm;Process;promoter;Promoter Regions;protein expression;Reporter;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Site;Solid Neoplasm;Subgroup;success;System;Testing;Therapeutic;Tissues;tool;Transplantation;Treatment Failure;tumor;Tumor stage;Western Blotting;whole genome;Work;Zebrafish

PROJECT_TITLE: Interplay between low levels of GAS7 expression and MYCN overexpression and its impact on neuroblastoma metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Tyrosine phosphatases are important regulators of information transfer in cells and can play causal role in human diseases when mutated and/or dysregulated. The development of effective tyrosine phosphatase-targeted therapies requires a clearer picture of the distinct biological roles of the 100 human tyrosine phosphatases and a deeper understanding of how these proteins are regulated. The research proposed here entails the development of new approaches to study tyrosine phosphatase structure and function, and these methods will help clarify the mechanisms by which tyrosine phosphatase activity contributes to both normal and aberrant cellular processes.

PI_NAMEs: SHAH, NEEL H (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Animals;Area;Biochemical;biochemical tools;Biochemistry;Biological;Biological Process;Biology;Cell Physiology;cell type;Cells;Development;Disease;Disparity;Drug resistance;Drug Targeting;Enzymes;experimental study;Goals;Human;human disease;immune activation;interest;Knowledge;Label;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methods;Molecular;Mutate;Mutation;mutation screening;novel strategies;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;Point Mutation;Post-Translational Protein Processing;preference;Protein Dephosphorylation;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;PTPN11 gene;Regulation;Research;resistance mutation;Role;Signal Transduction;Structure;T-Lymphocyte;targeted cancer therapy;targeted treatment;Techniques;Therapeutic;tool;Tyrosine;Tyrosine Phosphorylation;Work

PROJECT_TITLE: Probing tyrosine phosphatase structure and function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Relevance to public health. We aim to elucidate whether and how B cell antigen receptor (BCR) signaling can induce activation-induced deaminase (AID) expression, genomic instability, and lymphomagenesis in B cells. Completion of our proposed studies will lay a scientific foundation for better understanding the etiology of B cell lymphomagenesis, elucidating the mechanistic connection between autoimmunity and B cell lymphoma, and developing novel therapies by modulating BCR signaling pathways.

PI_NAMEs: WANG, JING HONG (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acceleration;activation-induced cytidine deaminase;Address;Affect;Affinity;Antibodies;Antigens;Autoantibodies;Autoantigens;Autoimmunity;autoreactive B cell;B Cell Proliferation;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;BIRC3 gene;Cancerous;CD80 Antigens;Cell Survival;Cells;Chromosomal translocation;Chronic;Data;Diagnostic;DNA;DNA Double Strand Break;Etiology;Exhibits;Foundations;Genome;genome-wide;Genomic Instability;Genomics;Goals;Hen Egg Lysozyme;Human;humoral immunity deficiency;Immunity;Immunization;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;In Vitro;in vivo;Infection;Injections;Licensing;Link;lymph nodes;Lymphocyte;Lymphoma;Lymphomagenesis;Malignant Neoplasms;Mantle Cell Lymphoma;Mature B-Lymphocyte;Mediating;Modeling;Mus;Mutagenesis;mutant;Mutation;Non-Hodgkin's Lymphoma;novel;novel therapeutics;NR0B2 gene;pathogen;Pathogenesis;Pathologic;Point Mutation;Price;Probability;Process;Production;prognostic;Protein phosphatase;Public Health;Receptor Activation;Receptor Signaling;Regulation;response;Role;Signal Induction;Signal Pathway;Signal Transduction;Spleen;SYK gene;T-Lymphocyte;Techniques;Testing;TNF Receptor-Associated Factors;TRAF2 gene;tumorigenesis

PROJECT_TITLE: B cell antigen receptor (BCR)-driven mechanistic connection between B cell lymphomagenesis and autoimmunity

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biotechnology;Clinical Research;Genetics;Human Genome;Lung;Organ Transplantation;Rare Diseases;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Lung transplant recipients that develop severe lung injury within days of transplantation are at high risk of chronic rejection and death. We propose that injury in the donor lung which is present prior to transplantation drives poor clinical outcomes after lung transplantation through release of cell-free DNA. In this application, we will use single-cell RNA sequencing and mass cytometry to define how donor lung injury causes release of cell-free DNA to drive poor clinical outcomes after lung transplantation in humans and then will use a novel multi-hit mouse model of donor lung injury to delineate the signaling pathways through which cell-free DNA augments ischemia-reperfusion injury.

PI_NAMEs: SHAVER, CIARA M (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Affect;Allografting;Animal Model;Appearance;Area;aspirate;Biological Markers;Biopsy;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;cell free DNA;cell injury;Cells;Cessation of life;Chronic;Clinical;clinically relevant;Coupled;Cytometry;Data;Detection;Development;DNA;Event;Frequencies;Functional disorder;Gene Activation;Genetic Transcription;graft dysfunction;high risk;Human;Immune;Immunogenomics;improved;Infection;Inflammation;Inflammatory;Injury;Ischemia;Knowledge;Lead;Lung;lung allograft;lung injury;Lung Transplantation;Maps;Measures;Modeling;Molecular;mortality risk;mouse model;Mus;NF-kappa B;novel;Outcome;Pathway interactions;Patients;Physicians;Physiological;Plasma;post-transplant;Predisposition;pulmonary function;Pulmonary Inflammation;radiological imaging;Recording of previous events;Reperfusion Injury;Reperfusion Therapy;Research;Risk;Role;Sampling;Scientist;sensor;Severities;Signal Pathway;Signal Transduction;single cell genomics;single-cell RNA sequencing;Speed;Stimulator of Interferon Genes;Testing;Time;Transplant Recipients;Transplantation

PROJECT_TITLE: Immunogenomic analysis of donor lung injury and its impact on clinical outcomes after lung transplantation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_DEPT: PHYSICS

PHR: PROJECT NARRATIVE With recent advances in the understandings of ribonucleoprotein (RNP) granules, it is becoming increasingly clear that the viscoelastic states of these granules play crucial roles in both cellular physiology and pathology. Nevertheless, mechanistic understandings of the determinants and modulators of RNP granule viscoelastic phases remain incomplete due to the limitations of currently available techniques that can directly probe protein condensate viscoelastic states. This project aims to develop a multi-parametric experimental toolbox based on correlative single- molecule fluorescence microscopy, multi-trap optical tweezer, and microfluidics, and apply these tools to (1) physiologic and (2) pathologic liquid-to-solid transformations of distinct RNP granule systems that are relevant to human health and diseases.

PI_NAMEs: BANERJEE, PRIYA R. (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Atomic Force Microscopy;C9ORF72;Cell Physiology;cellular pathology;Color;Cytoplasmic Granules;Development;Disease;DNA;DNA Binding;Enhancers;Fluorescence;Fluorescence Microscopy;Fluorescence Recovery After Photobleaching;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic Transcription;Goals;Health;Human;insight;laser tweezer;Length;Ligand Binding;Ligands;Liquid substance;Maps;Measurement;Microfluidics;Molecular;Mutation;nanoscale;Neurodegenerative Disorders;novel;Nucleic Acids;optic trap;optic tweezer;Pathologic;Pathway interactions;Phase;Phase Transition;Physical condensation;Physiological;Play;Post-Translational Protein Processing;Process;programs;Property;Protein Dynamics;Proteins;Regulation;Reporting;Research;Ribonucleoproteins;RNA;RNA Binding;Role;single molecule;Site;Solid;Structure;System;Techniques;tool;viscoelasticity

PROJECT_TITLE: Quantifying Physiologic and Pathologic Viscoelastic Phases of Biomolecular Condensates by Correlative Force and Fluorescence Microscopy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ORG_CITY: BROOMFIELD

ORG_NAME: COLORADO STATE DEPARTMENT/AGRICULTURE

PHR: Colorado Department of Agriculture The FDA’s Cooperative Agreement Program for States and Territories to  Implement a National Produce Safety Program  Funding Opportunity Number - PAR-21-174  Project Period 2021-2026  Program Narrative Colorado’s Produce Safety Program, which operates as part of the Inspection and Consumer Services Division of the Colorado Department of Agriculture, aims to improve the produce safety culture by enhancing the existing produce safety program in the state. Colorado’s Path C Produce Safety Cooperative Agreement to Implement a National Produce Safety Program Plan, intends to achieve that goal with farms that grow, harvest, pack or hold produce in Colorado by expanding on what the program achieved in the previous five year period, addressing new considerations and concerns that have risen since the program began, and establish metrics to meet the seven objectives defined in this cooperative agreement. With the ultimate goal of reducing illnesses and potentially deaths related to foodborne illnesses the Program feels it is essential to meet the seven objectives and increase compliance with the Produce Safety Rule.

PI_NAMEs: GLENN, HOLLIS ;SINNING, DUANE  (contact)

PROGRAM_OFFICER_NAME: HOEHNA, SHANNON

PROJECT_TITLE: Path C Colorado Produce Safety Cooperative Agreement to Implement a National Produce Safety Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE In 2020, a record 71,000 opioid overdose deaths occurred in the U.S, highlighting the importance of mitigating insurance-related barriers to accessing medications for opioid use disorder (MOUD). In this proposal, we will provide actionable, policy-relevant information on the effect of cost-sharing for MOUD in privately insured patients and on the effect of removing prior authorization requirements for MOUD in Medicaid patients. Results will inform and spur efforts to optimize insurance benefit design for MOUD in private and Medicaid plans, potentially leading to the removal of insurance-related barriers that may be contributing to rising opioid-related morbidity and mortality.

PI_NAMEs: CHUA, KAO-PING  (contact);NGUYEN, THUY DIEU

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Accounting;Address;Affect;age group;aged;American;Buprenorphine;Cessation of life;Coinsurance;Cost Sharing;Data;Databases;Deductibles;design;Drops;Drug Costs;Excision;FDA approved;federal policy;Formularies;Goals;Health Care Costs;Hospitalization;improved;Insurance;Insurance Benefits;Insurance Carriers;Intervention;Literature;Low income;Medicaid;Medicare;medication for opioid use disorder;Methadone;Modeling;Morbidity - disease rate;mortality;mortality risk;Naltrexone;Opioid;opioid mortality;opioid overdose;opioid use disorder;overdose risk;patient subsets;Patients;Pharmaceutical Preparations;Pharmacy facility;Policies;Policy Maker;Prescription drug overdose;prior authorization;Privatization;programs;Quasi-experiment;Reporting;Risk;Subgroup;Uninsured;Uninsured Medical Expense

PROJECT_TITLE: Insurance-related barriers to medications for opioid use disorder in private and Medicaid plans

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Humans adults are adept at seeing their way through complex visual environments, relying on cortical regions that respond selectively to visual scenes, but surprisingly little is known about how these cortical regions develop, partic- ularly in the ﬁrst year of life. Here we propose to use neuroimaging in awake infants to test how innate factors and independent navigational experience interact to shape the development of cortical scene processing. This work will help characterize human visual cortical function during its early plastic developmental phase, and provide a critical benchmark for future work on how these systems are disrupted in developmental disorders.

PI_NAMEs: SAXE, REBECCA R (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Age Months;aged;Area;awake;Behavioral;Benchmarking;Birth;Brain;Brain Injuries;Brain region;Categories;Clinical;Complex;Data;Data Set;Dedications;Development;developmental disease;developmental plasticity;Developmental Process;Ecological momentary assessment;Environment;experience;Exposure to;extrastriate visual cortex;Face;Foundations;Frequencies;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;Goals;Head;Human;Individual;infancy;Infant;Inherited;innovation;insight;Intervention;Investigation;Knowledge;Learning;Life;Literature;Location;Magnetic Resonance Imaging;Measures;Motion;Motor;Nature;Nerve Degeneration;neural;Neurodegenerative Disorders;neurodevelopment;neuroimaging;Neurologist;Neurons;novel strategies;Operative Surgical Procedures;Parietal;Pattern;Perception;Peripheral;Phase;Photic Stimulation;Predisposition;preference;Productivity;rehabilitation strategy;Rehabilitation therapy;remediation;Research;resilience;response;Rest;Role;Shapes;skills;statistics;Stimulus;Stroke;Structure;System;Techniques;Testing;theories;Time;Visual;Visual Cortex;visual information;Visual System;Work

PROJECT_TITLE: How do Cortical regions selective for visual scenes develop in human infants?

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Aging;Clinical Research;Hematology

PHR: Project Narrative  Patients with von Willebrand disease (VWD) are at increased risk for bleeding. Age may mitigate this risk. Little evidence is currently available to guide treatment in VWD patients whose von Willebrand factor levels have normalized with age. An enhanced understanding of the bleeding risk in older patients is critical because if they no longer bleed, VWD-specific therapy is costly and may increase the risk of thrombosis. Alternatively, if they continue to bleed, VWD-specific therapy may still be indicated. This study will help provide important new insights into this problem and provide more evidence to guide treatment and improve patient care.

PI_NAMEs: SEAMAN, CRAIG D (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adult;Affect;Age;age effect;age related;Aging;aging related disease;Assessment tool;biobank;Bioinformatics;Biology;Blood;Blood Coagulation Disorders;Blood specimen;candidate identification;Cardiovascular Diseases;Caring;Clinic Visits;Clinical;Clinical Research;Clinical Trials;comorbidity;Correlation Studies;cost;Cross-Sectional Studies;Data;DDAVP;Diagnosis;DNA;Elderly;Enrollment;Ensure;Epidemiology;epidemiology study;Estrogen Therapy;Evidence based practice;experience;Factor VIII;Factor VIII-Related Antigen;Future;Genes;Genetic;genomic locus;Goals;Healthcare;Hematologist;Hematology;Hemophilia A;Hemorrhage;Hemostatic function;improved;Inherited;insight;Investigation;Knowledge;Laboratories;Longitudinal, observational study;Medical;Mentored Patient-Oriented Research Career Development Award;Mentorship;multiple chronic conditions;Mutation;mutational status;Normal Range;older patient;Older Population;participant enrollment;Pathogenicity;Patient Care;Patients;Phenotype;Physicians;Population;Predisposition;Principal Investigator;Procedures;Process;prophylactic;Randomized;Recording of previous events;Research;Research Activity;Research Infrastructure;research study;Risk;Risk Factors;risk mitigation;Role;safety outcomes;Sampling;Scientist;skills;Symptoms;Testing;Thrombosis;Training;treatment center;trial comparing;unnecessary treatment;von Willebrand Disease;von Willebrand Factor;wasting

PROJECT_TITLE: The Von Willebrand Disease Aging and Bleeding Correlation (VWD ABC) Study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Mutations in the spliceosome gene SF3B1 are frequent in myelodysplastic syndromes (MDS), but how SF3B1 mutations cause the biologic and clinical phenotypes of these lethal blood disorders is not known. The premise of our proposal is that a key to gaining this knowledge is to study the differences between distinct SF3B1 mutations. We propose to use isogenic human cell models, primary MDS samples, and primary patient data to determine how distinct SF3B1 mutations produce biologic and clinical features of MDS.

PI_NAMEs: DALTON, WILLIAM BRIAN (contact);DEZERN, AMY E

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Affect;Amino Acids;Anemia;Biological;Biology;Blood Cells;Bone Marrow;Bone marrow failure;Cell model;Cells;Cellular biology;Clinical;Clinical Data;Clinical Investigator;clinical phenotype;Clinical Research;Collection;Computer Analysis;Credentialing;cytopenia;dalton;Data;Differentiation and Growth;Disease;disease classification;Disease Management;disease model;disease phenotype;disease prognosis;Dysmyelopoietic Syndromes;Erythroid;Event;fitness;Genes;Genetic;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;Hemorrhage;Heterogeneity;Human;human model;Impairment;improved;In Vitro;in vivo;Individual;Indolent;Infection;insight;Institution;Introns;Knowledge;Learning;Maps;Marrow;Mediating;Metabolic;Metabolism;Molecular Abnormality;Multiple Organ Failure;Multivariate Analysis;Mus;mutant;Mutate;Mutation;Myelogenous;National Heart, Lung, and Blood Institute;novel;novel therapeutic intervention;Outcome;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physicians;Privatization;Process;Production;Prognosis;Prognostic Marker;Progressive Disease;Publications;Publishing;Resources;response;response biomarker;Risk;RNA;RNA Splicing;Role;Sampling;Scientist;Serine;Sideroblast;Sideroblastic Anemia;Spliced Genes;Spliceosomes;stem cells;Testing;Therapeutic;transcriptome sequencing;treatment response;Work

PROJECT_TITLE: Biologic and Therapeutic Consequences of Distinct Hotspot SF3B1 Mutations in MDS

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Microenvironment-regulated mechanotransduction has significant influences on cell function and behavior across diverse organisms and its mis-regulation is at the heart of various pathologies. Unfortunately, current understanding on how mechanical stimuli from microenvironments are transduced into cellular signaling and what the relationships are between microenvironmental mechanics, cell signaling, gene expression, and cell functions has been limited. Discoveries from this work will provide a framework in fundamental understanding of mechanotransduction through a new nexus: calcium signaling and bring new opportunities to develop therapeutic strategies.

PI_NAMEs: TANG, XIN  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: 3-Dimensional;Actomyosin;Algorithms;Biological Process;Calcium;Calcium Oscillations;Calcium Signaling;cell behavior;Cell Line;cell motility;Cell Physiology;Cells;Chemicals;CRISPR imaging;Dissection;Epithelial Cells;extracellular;Foundations;Gene Expression;Genetic;Grant;Heart;innovation;insight;Knowledge;Link;live cell imaging;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Molecular;novel;Organism;Pathology;Physiological;Process;programs;Proteins;Research;sensor;Signal Transduction;success;System;Therapeutic;transcriptome;Work

PROJECT_TITLE: Mechanisms and Functions of Unconventional Intercellular Calcium Waves in Electrically Non-excitable Cells

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Dissemination and Implementation Research;Esophageal Cancer;Health Services;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Iron deficiency anemia (IDA) is a marker of various clinical conditions, including serious diagnoses such as gastrointestinal (GI) tract cancers, but it is not always identified by clinicians. Clinical prediction models could help clinicians to improve the diagnosis of GI tract cancer sooner using electronic health record (EHR) data, but clinical prediction models are not routinely used. This proposal will refine a prediction model for GI tract cancers, identify barriers to using the model, and design a strategy to help encourage clinicians to use the model.

PI_NAMEs: READ, ANDREW J (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;Algorithms;Attention;Award;Biometry;Blood Vessels;cancer diagnosis;career;Characteristics;Chronic;Clinical;clinical care;clinical implementation;clinical practice;clinical predictive model;Clinical Trials;Colorectal;Complete Blood Count;Consolidated Framework for Implementation Research;Data;Data Science;Data Scientist;Data Set;design;Detection;Development;Diagnosis;Diagnostic;digital;digital data;Disease;Electronic Health Record;Electronics;Erythrocytes;Evaluation;Future;Gastroenterologist;Goals;Health Services;Healthcare Systems;Hemoglobin;Hemorrhage;implementation facilitators;implementation framework;implementation science;implementation strategy;improved;in silico;innovation;Integrated Health Care Systems;Interview;Investigation;Iron;Iron deficiency anemia;Laboratories;Learning;Logic;Logistic Regressions;Machine Learning;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Maps;Medical;Methods;Michigan;model development;Modeling;Nature;novel;Occult blood screen;Patients;Pattern;Performance;prediction algorithm;Predictive Cancer Model;predictive modeling;predictive test;prospective;Reminder Systems;Research;Research Personnel;Scientist;screening;skills;Small Intestines;Specific qualifier value;Statistical Algorithm;Stomach;Structure;Surveys;System;Techniques;Testing;Theoretical Domains framework;tool;Training;Translational Research;translational scientist;Translations;United States;Universities;Veterans Health Administration;Width;Work

PROJECT_TITLE: Improving Diagnosis in Gastrointestinal Cancer: Integrating Prediction Models into Routine Clinical Care

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: RICHARDSON

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Catheter-associated urinary tract infections are accounting for more than 30% of acute care hospital infections. We proposed a durable fluid-like surface to change the solid/bacterial interaction to quasi-liquid/bacterial interaction on catheter materials. Such an integrated mechanobiological and microbiological approach will inhibit biofilm for over 30 days that cannot be achieved by existing approaches.

PI_NAMEs: DAI, XIANMING  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;acute care;Adsorption;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Adhesion;bacterial community;bactericide;Biological;Bladder;catheter associated UTI;Catheter Management;Catheterization;Catheters;Cells;Charge;chemical bond;Clinical;Collection;combat;Communities;Development;Electrostatics;Enterococcus faecalis;Escherichia coli;ethylene glycol;flexibility;fluidity;Gram-Negative Bacteria;Hour;Human;Hydrogels;implantable device;innovation;interfacial;intermolecular interaction;Invaded;Liquid substance;Medical center;Microbial Biofilms;Microbiology;Microfluidics;Molecular;Nosocomial Infections;novel;Nucleic Acids;Outcomes Research;pathogen;pathogenic bacteria;Patients;Polymers;polymicrobial biofilm;prevent;Property;Proteins;Pseudomonas aeruginosa;Sampling;Silanes;Silicones;Silver;Sodium Chloride;Solid;Surface;surface coating;Testing;Time;Urinary tract;Urine;Uropathogen;Viscosity

PROJECT_TITLE: Durable fluid-like surface for sustainable biofilm inhibition


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: DEAN III, DOUGLAS CARL (contact);POEHLMANN-TYNAN, JULIE A

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 21/24 Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PI_NAMEs: LEVITT, PAT  (contact);SMITH, BETH A;WISNOWSKI, JESSICA L

PROJECT_TITLE: 2/24 Healthy Brain and Child Development National Consortium


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Radiation Oncology

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: As a result of unanticipated respiratory motion, patients undergoing radiotherapy for lung cancer can experience damage to normal lung tissue and organs, reducing their quality of life and, potentially, causing post-treatment complications. In this proposal, we aim to combine two advanced imaging techniques – four- dimensional computed tomography and four-dimensional magnetic resonance imaging and build a patient- specific motion model that can estimate the entire volume in real-time. We expect that by knowing the motion and location of the tumor and every organ in the chest cavity, throughout the delivery of radiation, clinicians can deliver radiotherapy with more confidence and fewer side effects.

PI_NAMEs: ERNST, THOMAS M;SAWANT, AMIT  (contact)

PROGRAM_OFFICER_NAME: GRODZINSKI, PIOTR

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adoption;Aftercare;Anatomy;base;Breathing;Cancer Patient;Chest;Clinical;Clinical Research;clinical translation;Collaborations;Combined Modality Therapy;Complex;cost;Data;Dose;Electromagnetics;electron density;Engineering;Evaluation;experience;Failure;Fluoroscopy;Four-dimensional;four-dimensional computed tomography;Guidelines;image guided;image guided radiation therapy;Imaging Techniques;Industrialization;industry partner;Institution;interest;Lead;Location;Lung;Magnetic Resonance Imaging;Malignant neoplasm of lung;Maryland;Medical;Modeling;Monitor;Motion;novel;Optics;Organ;Patients;Performance;Photogrammetry;Positioning Attribute;pre-clinical;prospective;Prospective Studies;prototype;quality assurance;Quality of life;Radiation;radiation delivery;Radiation therapy;real time monitoring;Research;Research Design;Respiration;respiratory;response;Risk;Robin bird;sensor;Shapes;side effect;simulation;soft tissue;spatiotemporal;standard of care;Structure of parenchyma of lung;Surface;System;Techniques;Technology;Testing;Time;Toxic effect;translational approach;tumor;Update;Variant

PROJECT_TITLE: Personalized Motion Management for Truly 4D Lung Radiotherapy


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PI_NAMEs: FOX, NATHAN A (contact);HARDEN, BRENDA J;RIGGINS, TRACY L.

PROJECT_TITLE: 16/24 Healthy Brain and Child Development National Consortium


ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The Interdisciplinary Immunology Training Program at Yale University supports the education and training of the next generation of scientists who will study the fundamental principles of the immune system, the system of the body responsible for combating infectious diseases. Graduates from this program go on to leading positions in universities and industry, where they contribute to a deeper understanding of how the immune system functions with implications for the development of new vaccines, new therapies to combat viruses and bacteria, and new treatments for cancer, autoimmune, hypersensitivity and inflammatory diseases.

PI_NAMEs: ROTHLIN, CARLA ;SCHATZ, DAVID G. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Training Programs

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because cardiovascular disease represents a major national cost measured by both patient suffering and economic burden. Despite significant advances in care, clinical trial data demonstrates patients are facing another major complication; the development of heart failure. This research will stimulate the opening of a new avenue in therapeutics directed at a subset of macrophages that function within the inflammatory milieu of the cardiovascular system.

PI_NAMEs: SHAH, PREDIMAN KRISHAN (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acute myocardial infarction;Affect;Agonist;Area;Arterial Fatty Streak;Arterial Injury;Atherosclerosis;Attenuated;Biological Markers;Bone Marrow Transplantation;Cardiac;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Caring;Cell Culture Techniques;cell type;Cells;Cholesterol;chronic inflammatory disease;Clinical;clinical practice;Clinical Trials;Complication;Cost Measures;Data;Developing Countries;Development;Disease;Disease Progression;Economic Burden;Environment;Event;experience;Experimental Models;Future;GATA3 gene;Genetic Transcription;Goals;healing;Heart;Heart Diseases;Heart failure;heart function;Homeostasis;Human;Human Activities;Human Pathology;Immune;Immunology;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injury;innovation;insight;Interleukin-4;Investigation;Investigational Therapies;Ischemic Stroke;Knock-out;Knowledge;Left Ventricular Remodeling;Leukocytes;Macrophage;Measures;Mediating;monocyte;mortality;mouse model;Mus;Myeloid Cells;Myocardial;Myocardial Infarction;myocardial injury;Myocarditis;Myocardium;Neutrophil Infiltration;novel;novel therapeutic intervention;novel therapeutics;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;Phenotype;Play;pre-clinical;prevent;Process;Public Health;Qualifying;recruit;Regulation;Reporting;Research;Role;Signal Pathway;Signal Transduction;single cell technology;Site;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Time;tool;Translations;Transplantation Immunology;vascular inflammation;viral myocarditis

PROJECT_TITLE: The role of GATA3-positive macrophages in cardiovascular pathologies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Around the world there is a growing need to develop early intervention services in local communities that support a better quality of life for all autistic people. Our South African study will test an approach where caregivers are coached by non-specialists in early intervention strategies. Caregivers can then use these strategies during everyday activities with their young autistic child.

PI_NAMEs: FRANZ, LAUREN  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Acceleration;Adaptive Behaviors;Address;Adopted;Advocate;Africa;African;Age;autism spectrum disorder;autistic;autistic children;Behavior;Behavior Therapy;care systems;career;caregiver interventions;Caregivers;Characteristics;Child;Communication;Communities;community academic partnership;community based service;Computer software;cost;Cost Analysis;cost effectiveness;Data;design;Development;digital assessment;Dimensions;Distal;early childhood;Early Intervention;Education;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Environment;Europe;evidence base;Evidence based intervention;experience;Face;Family;Future;Goals;Home;implementation barriers;implementation determinants;implementation framework;implementation strategy;improved;improved outcome;Income;Individual;individuals with autism spectrum disorder;innovation;insight;Intervention;Intervention Trial;Language;Learning;Linguistics;low and middle-income countries;Measures;Medical center;member;Methods;mindfulness;Modeling;neural;North America;Outcome;Participant;Pattern;phenomenological models;phenotypic data;Policy Maker;Population;programs;Quality of life;Randomized;Research;Research Personnel;Research Training;Resolution;response;scale up;service intervention;Services;skills;social;social engagement;social learning;South Africa;South African;Specialist;stakeholder perspectives;System;Tanzania;Testing;treatment as usual;Universities;Work;Workforce Development;World Health

PROJECT_TITLE: Autism Caregiver Coaching in Africa


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LEXINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: My research leverages the experimental tractability and remarkable regenerative abilities of planarian flatworms to uncover fundamental molecular mechanisms that link injury-induced signals to functional changes in gene expression. My lab uses custom techniques, innovative biochemical methods, and comparative species approaches to identify specific protein factors that regulate genome accessibility at essential gene targets. Preliminary data from my lab suggests that the chromatin modifying protein MLL1/2 maintains its conserved molecular and developmental role in planarians, yet by regulating novel genomic targets.

PI_NAMEs: DUNCAN, ELIZABETH MARIE (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Animal Model;Animals;Biochemical;Biological Process;cell type;Cells;Chromatin;Cilia;comparative;comparative genomics;Complex;Cues;Custom;Data;Development;Developmental Process;Dissociation;Embryonic Development;Enzymes;Epithelium;Essential Genes;Event;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Genetic Transcription;Genome;Genomic approach;Genomics;Heterogeneity;in vivo;Injury;innovation;interest;Laboratory Study;Link;Mediator;Methods;MLL gene;Molecular;Natural regeneration;novel;Organism;Pattern;Planarians;Platyhelminths;Pluripotent Stem Cells;Population Heterogeneity;Process;Proteins;regenerative;Regenerative capacity;Regulation;Research;response;RNA Interference;Role;Signal Induction;Signal Transduction;single cell analysis;stem cell function;stem cells;Structure;Techniques;Testing;Tissue Differentiation;tissue regeneration;Tissues;trait;transcription factor;Translating;Work

PROJECT_TITLE: Chromatin Regulation of Tissue Regeneration and Stem Cell Function


ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Mitochondria are the energy powerhouses of the cell, and energy metabolism plays a critical role in the etiology of cardiometabolic diseases. To understand the molecular basis underlying mitochondrial DNA (mtDNA) and cardiometabolic diseases, we will perform association analyses to identify mtDNA-associated DNA methylation sites and mtDNA-associated gene expression levels, and will perform mediation and integrative analyses as well as functional characterization to investigate pathway and gene networks linking mtDNA and cardiometabolic diseases. The body of knowledge generated by this research project will deepen our understanding of molecular mechanisms underlying mtDNA and cardiometabolic diseases, which will ultimately facilitate the development of new modalities for the diagnosis, prevention, and treatment of cardiometabolic diseases.

PI_NAMEs: LIU, CHUNYU  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Affect;Aging;Anabolism;Applications Grants;Blood;Blood Glucose;Body mass index;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;Cell Line;Cells;Cellular Metabolic Process;cohort;Communities;CRISPR/Cas technology;Databases;Development;Diagnosis;Disease;disorder risk;DNA Methylation;Elderly;Energy Metabolism;epigenome-wide association studies;Etiology;European;Event;factor A;Fasting;Gene Expression;Gene Expression Regulation;gene network;Gene Proteins;gene regulatory network;Genes;genetic epidemiology;Genome;genome sequencing;Genotype;Heart;heteroplasmy;human disease;Hybrids;Impairment;Knock-out;Knowledge;Link;low density lipoprotein triglyceride;Maintenance;Measures;Mediating;Mediation;Metabolic syndrome;Methylation;methylation pattern;Mitochondria;Mitochondrial DNA;Modality;Modeling;Modification;Molecular;mouse model;Mouse Strains;mtTF1 transcription factor;multiple omics;Mus;Mutation;National Heart, Lung, and Blood Institute;Nuclear;Obesity;open source;Participant;Pathway interactions;peripheral blood;Play;Polymerase;Prevention;Production;programs;protein protein interaction;Proteins;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Role;Site;System;Testing;Tissues;Titrations;trait;Trans-Omics for Precision Medicine;Transcript;transcription factor;Translations;Whole Blood;whole genome

PROJECT_TITLE: Mitochondrial DNA, Nuclear DNA Methylation, and Cardiometabolic Disease Traits

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: In this pragmatic clinical trial, we will study [214] older Veterans approaching surgery for gastrointestinal or genitourinary cancer [(Stage II-III)] who are at high risk for a marked decline in their physical function. We will test a multi-targeted nutrition regimen high in protein and other key nutrients and including [low- intensity] resistance exercise, administered 8 weeks prior to surgery and for 24 weeks after [discharge from surgery], with the goal of protecting [physical function] and improving [physiologic, metabolic], and patient- centered outcomes. The findings of this study will promote a better intervention to compensate for the high nutritional demands of cancer and its treatment and lead to stronger, more rapid physical recoveries and better quality of life for older adults with moderate to advanced cancer—a group that has rarely been included in long- term nutrition studies. In addition to providing direct benefits to Veterans, the study may also benefit the VA by decreasing demands on the health care system via hastening the recovery of physical function.

PI_NAMEs: BALES, CONNIE W (contact);STARR, KATHRYN N

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Advanced Malignant Neoplasm;age-related muscle loss;aged;Amino Acids;Anabolism;Anorexia;appetite loss;beta-hydroxyisovaleric acid;Biphasic Pattern;Cachexia;Cancer Cachexia;Cancer Etiology;cancer surgery;Cancer Survivor;cancer therapy;chemotherapy;Clinical;combat;Compensation;coping;Data;Deterioration;Dietary Intervention;Dimensions;Disease;effective intervention;efficacy evaluation;Eligibility Determination;Enrollment;exercise intensity;exercise intervention;experience;Face;Frail Elderly;frailty;functional decline;functional improvement;functional restoration;gastrointestinal;Gastrointestinal Surgical Procedures;Genitourinary system;Goals;Health;Healthcare Systems;high risk;high risk population;Impaired wound healing;improved;Inflammation;Intervention;Knowledge;Leucine;Link;lipid metabolism;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Malnutrition;Metabolic;Mission;Morbidity - disease rate;mortality;Multivitamin;Muscle;Muscle function;Muscular Atrophy;Musculoskeletal;neglect;novel;Nutrient;nutrition;nutrition related cancer;Nutritional;Nutritional Support;older adult;older patient;Operative Surgical Procedures;Ostomy;Outcome;Outcome Measure;Patient-Focused Outcomes;Patients;Perioperative;Personal Satisfaction;Phase;Physical Function;Physiological;Population;Postoperative Complications;Postoperative Period;Pragmatic clinical trial;preservation;prevent;protein metabolism;Protein-Energy Malnutrition;Proteins;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;reduce symptoms;Regimen;Research;research and development;resistance exercise;restoration;Risk;Risk Factors;secondary outcome;side effect;Surgical complication;Symptom Burden;symptomatic improvement;Symptoms;systemic inflammatory response;targeted treatment;Testing;treatment arm;treatment optimization;tumor progression;Urogenital Cancer;Veterans;Vitamin A;Vitamin D;Vomiting;Walking

PROJECT_TITLE: Preserving Physical Function in Older Adults with Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Limiting the emergence and spread of multidrug-resistant bacteria among patients requiring maintenance hemodialysis, by improving antimicrobial prescribing patterns, will decrease the morbidity and mortality of this patient population. Our previous antimicrobial stewardship program in out-patient dialysis facilities demonstrated statistically significant reductions in antimicrobial use. In this proposal, we will develop and implement an improved antimicrobial stewardship program, which will address the barriers identified in our previous successful program.

PI_NAMEs: D'AGATA, ERIKA M (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Optimizing Antimicrobial Use in Maintenance Dialysis Units (OPTIMUS)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_CITY: REYNOLDSBURG

ORG_NAME: OHIO STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: OH

PHR: Increasing the Capability and Capacity of Microbiological and Chemical Testing to Support an Integrated Food Defense and Food Safety System Overall Component Project Narrative Federal and state collaboration is essential to a secure national food supply, and the goals of increasing sampling numbers, contributing to the national genome and food safety databases and incorporating new or improved methods directly impact the effectiveness in fulfilling the mission of the Food Safety Modernization Act. Increased capability and capacity will improve state and federal incident response speed through faster testing turnaround times, improved interagency communications, more defensible data and provides for immediate regulatory action to prevent or reduce the scale of harm from any present or future event.

PI_NAMEs: KONG, JASON SIU (contact);PRARAT, MELANIE ;ROSA, YAMIR

PROGRAM_OFFICER_NAME: LI, MEI-YING


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative The overall objectives of this project are to identify the localization, the source, the characteristics and the mechanisms of action of Th17 cells in depressive-like behaviors and determine targeted strategy by which Th17 cell production following stress can be blocked in order to develop a new therapeutic strategy for depression, a prevalent, debilitating, and inadequately treated disease.

PI_NAMEs: BEUREL, ELEONORE  (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Affect;American;antagonist;anti-CD20;anti-depressive agents;Antibodies;antidepressant effect;Astrocytes;Autoimmune Diseases;B-Lymphocytes;Bacteria;Behavior;biomarker identification;Blood;BLR1 gene;Brain;brain parenchyma;Brain region;CCR6 gene;CD4 Positive T Lymphocytes;cell killing;Cells;Characteristics;Chronic;Clinical;Communication;connectome;cytokine;Cytolysis;Data;depression model;depressive symptoms;Development;Disease;Drug Delivery Systems;effective therapy;effector T cell;efficacious treatment;Engineering;Escherichia coli;Exhibits;Flow Cytometry;Grant;Hippocampus;IL17 gene;improved;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Knock-out;Label;Lead;Learned Helplessness;Link;Major Depressive Disorder;Maps;Measures;Mental Depression;Mental disorders;Microglia;Modeling;mouse model;Multiple Sclerosis;Mus;nanobodies;nanoparticle;Nature;Neurodegenerative Disorders;Neurons;new therapeutic target;novel therapeutic intervention;Outcome;Pathogenicity;Patients;Peripheral;Persons;Predisposition;Prefrontal Cortex;prevent;Production;Psoriasis;quorum sensing;Regulatory T-Lymphocyte;Research;restraint stress;Rheumatoid Arthritis;Rodent;Role;Scheme;side effect;Signal Transduction;Source;Sphingosine-1-Phosphate Receptor;Stress;T cell infiltration;T cell receptor repertoire sequencing;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Transgenic Mice;VAI-2;Visualization;Wild Type Mouse

PROJECT_TITLE: Th17 cells as a new therapeutic target for depression

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Hematology;Liver Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Erythropoietic protoporphyria (EPP) results from pathogenic variants of the last enzyme of heme biosynthesis causing life-long, painful cutaneous sensitivity to light. The objective of this study is to develop methods to quantitatively measure light sensitivity in EPP and to understand the genetic basis for differences in light sensitivity among patients. This project could lead to (1) methods to predict and prevent photosensitivity in EPP thus improving quality of life, (2) quantitative endpoints for clinical trials facilitating the approval of new therapies, and (3) a better understanding of the modulators of light sensitivity in EPP, which could lead to novel therapeutics.

PI_NAMEs: DICKEY, AMY KATHRYN (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: afamelanotide;Affect;Anemia;Biological Markers;career;CD34 gene;Cells;Characteristics;Chemicals;Cholelithiasis;Cholestasis;chronic liver disease;Clinical;Clinical Trials;Clinical Trials Design;Code;CRISPR/Cas technology;Cutaneous;Data;Data Collection;detector;Development;Devices;digital;Digital biomarker;Disease;Dose;Drug Targeting;Environmental Epidemiology;Enzymes;Epidemiology;Erythrocytes;Erythropoietic Protoporphyria;exome;exome sequencing;Family;Fluorescence;Fluorometry;General Hospitals;Genes;Genetic;genetic analysis;genetic epidemiology;Genotype;Goals;Grant;Heme;heme biosynthesis;improved;In Vitro;in vitro testing;Individual;instructor;iron metabolism;large datasets;Life;Light;light dosimetry;Liver;Liver Failure;liver transplantation;Massachusetts;Measurement;Measures;medical schools;Medicine;Melanins;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolism;Methodology;Methods;Molecular Target;Monitor;Narcotics;new therapeutic target;novel;novel therapeutics;Pain;Pathogenicity;patient oriented;patient population;Patient Selection;patient variability;Patients;Photophobia;Photosensitivity;Photosensitivity Disorders;Physicians;Pilot Projects;Plasma;polygenic risk score;Porphyrias;Porphyrins;Positioning Attribute;pre-clinical;prevent;Prevention;protoporphyrin IX;Quality of life;randomized, clinical trials;rare genetic disorder;Reaction;Research;Research Personnel;Resources;response;Risk;Scientist;Severities;Skin tanning;Standardization;statistics;Sunscreening Agents;Surveys;Symptoms;Testing;Text;therapeutic target;tool;Training;trait;treatment effect;treatment response;Ultraviolet Rays;United States Food and Drug Administration;Validation;Variant;wearable device

PROJECT_TITLE: Measuring and Understanding Light Sensitivity in Erythropoietic Protoporphyria

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Factors Associated with Response to Cardiac Resynchronization Therapy in Heart Failure Patients with Non-LBBB ECG Pattern Cardiac resynchronization therapy with a defibrillator (CRT-D) in heart failure (HF) patients without left bundle branch block (non-LBBB) has been less beneficial to improve outcomes despite being a guideline indicated therapy, posing a significant treatment challenge. However, non-LBBB patients with echocardiography response to CRT-D have better outcomes, and pre-implant variables could predict response, identifying patients who benefit the most. In this study, we plan to enroll 270 HF patients with non-LBBB and guideline- indicated CRT-D implantation to validate our prior echocardiography predictor score, and to identify novel ECG and echocardiography predictors using conventional statistics and machine learning analysis. We will also assess the applicability of such a score for clinical outcomes of HF, ventricular arrhythmias, or death.

PI_NAMEs: VALENTINA KUTYIFA, VALENTINA KUTYIFA VALENTINA KUTYIFA (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: arm;Arrhythmia;Attenuated;Biological;Bundle-Branch Block;cardiac implant;cardiac resynchronization therapy;Cessation of life;Clinical;clinical outcome assessment;clinical predictors;cohort;Congresses;cost;Data;Data Analyses;Defibrillators;Devices;Doctor of Philosophy;Echocardiography;EFRAC;Electrocardiogram;Enrollment;Event;follow-up;Guidelines;Health Care Costs;Heart;Heart failure;Heart Rate;Image;Implant;implantation;improved;improved outcome;innovation;kidney dysfunction;Left;Machine Learning;machine learning method;Mechanics;Medical center;Methods;Modeling;Morbidity - disease rate;mortality;Mosses;New York;novel;Outcome;patient population;Patient Selection;Patients;Pattern;predicting response;Predictive Factor;predictive modeling;Predictive Value;prospective;Prospective cohort;response;Risk;Statistical Methods;statistics;study population;Sum;Symptoms;Systolic heart failure;Testing;Treatment Cost;Universities;Ventricular;Ventricular Arrhythmia;Ventricular End-Systolic Volumes


ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA DEPT OF AGRICULTURE/FORESTRY

ORG_STATE: LA

PHR: Project Narrative Funding under this cooperative agreement will increase the capacity and capability of the Agricultural Chemistry Laboratory to test animal food products for both microbiological and chemical constituents in order to strengthen and improve FDA’s efforts to prevent foodborne illnesses and minimize foodborne exposures by adding to the integrated food safety system established by the FDA.

PI_NAMEs: CUROLE, DEEPIKA  (contact)

PROJECT_TITLE: LDAF/ LSU AgCenter Agricultural Chemistry Laboratory Enhancement of Capabilities to Support an Integrated Food Safety System Through Testing Activities in Areas of Microbiology & Chemistry