ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Dissemination and Implementation Research;Infectious Diseases;Prevention;Vector-Borne Diseases

ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: Project Narrative This D43 International Research Training Grant award will develop an Integrated Interdisciplinary VBD Research Training Program where researchers will work under close supervision of a Transdisciplinary Research Advisory Committee that will ensure learning by integration of multidisciplinary methods and concepts, and help researchers develop integrated research strategies. This program will foster the use of metagenomic, bioinformatics, mathematical modelling, implementation science and advanced immunologic techniques to examine relationships between pathogens, vectors, hosts, and their environments. This program will also develop a transdisciplinary VBD Professionals’ Learning Network in Pakistan that will bring frontline researchers across disciplines to engage and exchange VBD linked information using a One Health framework.

PI_NAMEs: KHAN, ERUM  (contact);VAN VOORHIS, WESLEY C

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Advisory Committees;Animals;Bioinformatics;Biology;Case Study;Central Asia;Certification;climate change;climate impact;Collaborations;Diagnostic;Discipline;Disease;Disease Surveillance;disorder control;disorder prevention;Doctor of Philosophy;Ensure;Environment;Epidemiology;experience;Faculty;Fogarty International Center;Fostering;global health;Health;high risk;Human;Immunologic Techniques;implementation intervention;implementation science;innovation;Interdisciplinary Study;International;Learning;learning network;mathematical model;Medicine;Mentors;Metagenomics;Methods;Middle East;multidisciplinary;Pakistan;pathogen;Pathology;Peer Review;Policies;Prevalence;programs;Publications;Recording of previous events;Research;Research Personnel;Research Support;Research Training;Series;skills;Supervision;Training;Training Programs;Universities;vector;Vector-transmitted infectious disease;virology;Washington;Work

PROJECT_TITLE: Integrated Research Training on Vector Borne Diseases in Pakistan: Vector Biology, Virology and Disease Epidemiology.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (55)]


ADMINISTERING_IC: ES

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Prevention

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Proposal Narrative As cyanobacterial harmful algal blooms (cyanoHABs) expand geographically and in their ability to produce more potent and deadly cyanotoxins, the globe is in need of a framework and highly resolved time series datasets to disentangle and model the complex biosynthetic dynamics by toxic cyanobacteria from varying genera. Standard techniques for assessing cyanoHAB risk towards public health have mainly consisted of monitoring for individual cyanotoxins, neglecting the wide breadth of toxic metabolites produced by cyanobacteria in freshwater. This proposal combines field and laboratory studies with multi-omic and bioassay techniques to curate big, accessible datasets on cyanoHABs in the Great Lakes region and identify the drivers and dangers of cyanoHAB toxins from a holistic perspective.

PI_NAMEs: HART, LAUREN  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acute;Address;aerosolized;Anabolism;Anatoxins;anthropogenesis;Automobile Driving;Biological Assay;Chemicals;Chronic;climate variability;cold temperature;Communities;Complex;cyanobacterial toxin;Cyanobacterium;Cyanotoxin;Data;Data Set;Development;DNA sequencing;drinking water;Economics;environmental change;Environmental Exposure;Environmental Health;Environmental Risk Factor;Eutrophication;Event;exposed human population;Exposure to;Family;field study;Fresh Water;Gene Cluster;Genetic;Genetic Transcription;Genomics;Geography;Goals;Great Lakes Region;Habitats;harmful algal blooms;Health;Hepatotoxicity;hepatotoxin;Heterogeneity;Human;Human Cell Line;improved;Individual;insight;Investigation;Laboratory Study;Link;metabolomics;Metagenomics;metatranscriptomics;Methods;microbial community;microcystin;Microcystis;microorganism;Mining;Modeling;Monitor;Multiomic Data;multiple omics;Natural Resources;neglect;Neurotoxins;Nitrogen;novel;Nutrient;Pattern;Persons;Prevention;Production;Proliferating;Property;Public Health;Research;Risk;Risk Assessment;Sampling;Saxitoxin;Seasons;Series;Shapes;Source;spatiotemporal;Statistical Models;success;Techniques;Temperature;Testing;Time;Toxic effect;Toxicology;Toxin;Water Supply;Work

PROJECT_TITLE: Disentangling the Drivers and Dangers of Toxic Cyanobacteria Biosynthetic Heterogeneity in Cyanobacterial Harmful Algal Blooms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The organization of the eukaryotic genomes in the form of chromatin, has fundamental implications for all processes that require access to the information encoded in DNA. The 2024 Chromatin Structure and Function GRC/GRS will bring together researchers with diverse backgrounds to discuss progress and breakthroughs in understanding how chromatin organization controls various genome functions, and how defects in chromatin- based regulation relate to human disease.

PI_NAMEs: NARLIKAR, GEETA J (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Acceleration;Access to Information;Address;Adoption;Area;Behavior;Biochemistry;Biology;career;Cell model;cell type;Chemicals;Chromatin;Chromatin Structure;Chromosomes;Classification;Collaborations;Defect;Development;Discipline;Disease;DNA;DNA Damage;Dosage Compensation (Genetics);Education;epigenome;experience;Fostering;Generations;Genome;genome-wide;Genomics;Heterochromatin;human disease;interdisciplinary approach;International;Knowledge;Learning;Maintenance;Malignant Neoplasms;meetings;member;Methodology;Modeling;Molecular;Molecular Conformation;new technology;novel;novel strategies;novel therapeutic intervention;Nucleosomes;Oral;Outcome;Participant;Pathology;Physiology;Play;posters;Process;Recording of previous events;Regulation;Request for Proposals;Research;Research Personnel;Rhode Island;Role;Schedule;Scientist;Series;Shapes;structural biology;symposium;synthetic biology;Technology;Testing;Thinking;Time;Tissues;Transcriptional Regulation;Underrepresented Populations;Universities;Visualization;Work

PROJECT_TITLE: 2024 Chromatin Structure and Function Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Huntington's Disease;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Protein aggregation is a hallmark of neurodegeneration and is the cause of the nine polyglutamine diseases. The goal of my proposed project is to use both genetic and biochemical approaches to discover factors that suppress polyglutamine aggregation in Dictyostelium discoideum, an amoeba that is uniquely resistant to this phenomenon. Once identified, these factors may be utilized to aid in the development of novel therapies for these incurable diseases.

PI_NAMEs: WILLIAMS, FELICIA NICOLE (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Address;Amoeba genus;amyloid formation;Awareness;Behavior;Biochemical;Biology;CAG repeat;career;Cell Physiology;Cells;Characteristics;Code;Complex;Data;Development;Dictyostelium;Dictyostelium discoideum;Disease;driving force;Exons;experimental study;Fellowship;Generations;Genes;Genetic;Genome;Glutamine;Goals;Heat Stress;Human;human disease;Huntington Disease;Huntington gene;In Vitro;insight;Investigation;Knowledge;Label;Laboratories;model organism;Modeling;mutant;Natural Resistance;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;novel;novel therapeutics;Organism;Orthologous Gene;Pathogenicity;polyglutamine;prion-like;Prions;Process;protein aggregation;Proteins;Proteome;proteostasis;PrP;Repression;Research;Resistance;Role;Series;social;Solubility;Spinocerebellar Ataxias;sup35;Techniques;Testing;therapy development;Toxic effect;trait;Translational Research;Yeast Model System;yeast prion;Yeasts

PROJECT_TITLE: Novel Insights into the Role of Prions in Polyglutamine Protein Homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NAIROBI CITY

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYA MEDICAL RESEARCH INSTITUTE (KEMRI)

PHR: Program Narrative Eastern Africa bears substantial burden of zoonotic diseases. The OHEART program targets Kenya and Ethiopia, fostering collaboration with institutions such as KEMRI, University of Nairobi, University of Gondar, AHRI, and The Ohio State University. The program aims to enhance research, leadership, cross-border cooperation, and interdisciplinary training to combat infectious diseases.

PI_NAMEs: GEBREYES, WONDWOSSEN A.;KARIUKI, SAMUEL M (contact);WANG, SHU-HUA

PROJECT_TERMS: Address;Africa South of the Sahara;Animals;Applied Research;Area;Avian Influenza;Birds;burden of illness;Camels;certificate program;Chiroptera;Collaborations;collaborative environment;Communicable Diseases;Competence;Country;COVID-19;Data;Data Analytics;Data Science;Discipline;Discipline of Nursing;disease transmission;Doctor of Philosophy;Eastern Africa;Ebola;Ensure;Environment;Environmental Science;Epidemic;Ethiopia;Face;Fellowship;Food;Fostering;Fruit;Future;global health;Health;Health Sciences;Home;Human;implementation science;Institution;Kenya;Laboratories;Leadership;Livestock;Medical Research;Medicine;Mentors;Middle East Respiratory Syndrome;Ohio;pandemic disease;pathogen;Pathogenicity;Persons;Phase;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Research;Research Institute;Research Personnel;Research Training;scale up;success;Training;Training Programs;Universities;Vector-transmitted infectious disease;Veterinary Medicine;Virus Diseases;Visit;waterborne;Zoonoses

PROJECT_TITLE: Sustainable One Health Research Training Capacity in Eastern Africa


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Female patients exhibit increased pain sensitivity and increased risk for developing chronic pain. This project will identify mechanisms underlying this sex difference by investigating pain signaling circuitry. Elucidating mechanistic sex-differences in pain is important for identifying potential sex-specific pain interventions.

PI_NAMEs: LORSUNG, REBECCA MARY (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: addiction;Address;Adverse reactions;Affective;antagonist;Automobile Driving;Back;Beds;Behavioral;Brain;Brain region;Brain Stem;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;career;Cell Nucleus;Cells;central pain;Chemosensitization;Chlorides;Chronic;chronic neuropathic pain;chronic pain;conditioned place preference;constriction;design;Development;Disinhibition;Electrophysiology (science);Emotional;Enhancers;Event;Exhibits;Face;Feedback;Female;gamma-Aminobutyric Acid;Glutamates;Goals;high risk;Infusion procedures;Intervention;Link;male;Measures;Mentors;Mentorship;Mus;Neurons;Neuropeptides;Opioid;Optics;optogenetics;Pain;pain behavior;Pain Disorder;Pain management;pain perception;pain processing;pain sensitivity;pain signal;painful neuropathy;parabrachial nucleus;Peptide Signal Sequences;Perception;Physicians;postsynaptic;Potassium;pre-clinical;Predisposition;response;Rewards;Risk;Role;Sensory;sex;Sex Differences;sexual dimorphism;Sexual Dysfunction;Signal Transduction;skills;Slice;Source;Strontium;Structure;Structure of terminal stria nuclei of preoptic region;Surgical Models;symporter;Synapses;Testing;Training;Trigeminal nerve structure;women patients;women versus men

PROJECT_TITLE: Sex Differences in the Bed Nucleus of the Stria Terminalis Guide Differential Pain Susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE  Social isolation and loneliness are associated with a greater risk of heart disease and cardiovascular risk factors across the lifespan; improving social connection can profoundly mitigate the effects of loneliness, but it is unclear what makes some people better than others at social-relational learning and forming interpersonal connections. The proposed research explores the individual behavioral, physiological, and neurocognitive mechanisms that underlie effective social-relational learning and models how social-relational learning impacts integration and well-being within a real-world, dynamic social network at the crucial period of early adulthood. This research will close theoretical and empirical gaps in understanding the factors that contribute to effective social-relational learning and may inform the development of strategies and interventions focused on improving social integration and reducing the risk of cardiovascular diseases.

PI_NAMEs: SCHMIDT, HELEN  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;aged;analytical method;Behavioral;Biological;Brain;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Career Choice;cohort;Community Integration;Data;Data Collection;Decision Making;Development;disorder risk;Early Intervention;emerging adult;Empirical Research;Enrollment;Evaluation;experience;experimental study;Failure;Feeling;Friends;Friendships;Functional Magnetic Resonance Imaging;Health;Heart;heart disease risk;Heart Rate;heart rate variability;Hypertension;improved;Individual;Individual Differences;interest;Intervention;Knowledge;Learning;Life;life span;Loneliness;Longitudinal Studies;Measures;member;Mental Health;Mentorship;Methods;Modeling;Multivariate Analysis;Names;neural;Neurocognitive;neuroimaging;novel;Obesity;Occupations;Outcome;Participant;Pattern;Performance at work;Personal Satisfaction;Persons;physical conditioning;Physiological;predicting response;Prefrontal Cortex;Premature Mortality;Prevention;Process;programs;protective effect;Psyche structure;psychologic;public health priorities;Questionnaires;recruit;Reporting;Research;response;Rest;Retirement;Risk;Risk Reduction;Scanning;Schools;Signal Transduction;social;Social Environment;social integration;Social isolation;social learning;Social Network;social structure;Social support;Stretching;Stroke;Structure;Students;success;Surveys;Survivors;Techniques;Television;Testing;Time;Training;undergraduate student;United States;Universities;Ventral Striatum;Work

PROJECT_TITLE: Friends are good for the heart: Investigating neurocognitive mechanisms underlying successful social learning that can reduce loneliness and associated cardiovascular diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative  The proposed work describes a light-driven deracemization method for compounds containing benzylic motifs commonly found in pharmaceuticals and mechanistic investigations of that system. Our approach employs a photocatalytic stereoablation process that generates a prochiral intermediate that undergoes asymmetric proton transfer by a chiral co- catalyst. Preliminary mechanistic data indicates that these types of deracemization reactions can occur with high enantioenrichment even when the elementary steps that comprise these processes have undesirable degrees of stereoselectivity.

PI_NAMEs: WANG, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TITLE: Photoredox-enabled deracemization: method development and mechanistic studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The emergence of SARS-CoV-2 has resulted in a global pandemic with variants that continue to spread via infection of the respiratory epithelium. Although viral entry is a critical step of infection, the full spectrum of proteins involved and how they are regulated is incompletely understood. This project aims to clarify the mechanisms of regulation of the ACE2 entry receptor by SARS-CoV-2 entry inhibitors to deepen our understanding of coronavirus infections and inform antiviral interventions.

PI_NAMEs: ACUNA, JORGE ALBERTO (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: 2019-nCoV;ACE2;airway epithelium;Bacterial Toxins;Binding;Biological Assay;Cathepsins;Cell Line;Cell membrane;Cell Physiology;cell type;Cells;Confocal Microscopy;Coronavirus;Coronavirus Infections;Data;desensitization;Disease Outbreaks;drug sensitivity;Epithelial Cells;experimental study;Flow Cytometry;Glycoproteins;human disease;Infection;inhibitor;insight;Integration Host Factors;Intervention;Isoenzymes;knock-down;Measures;Membrane;Membrane Fusion;Molecular;Morphology;novel;pandemic disease;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Process;Production;protein expression;Protein Isoforms;Protein Kinase C;Protein Kinase C Inhibitor;protein transport;Proteins;Public Health;receptor;Receptor Cell;receptor expression;Recombinants;Recycling;Regulation;respiratory;Respiratory Tract Infections;RNA Interference;Role;SARS-CoV-2 entry inhibitor;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;Serine Protease;Signal Pathway;Site;Small Interfering RNA;Staurosporine;Surface;targeted treatment;Testing;therapeutic development;Time;TMPRSS2 gene;trafficking;transmission process;uptake;Variant;Vesicular stomatitis Indiana virus;Viral;viral entry inhibitor;Viral Physiology;viral RNA;Virion;Virus;Virus Diseases;Western Blotting;Work;Zoonoses;zoonotic coronavirus

PROJECT_TITLE: Defining Mechanisms of SARS-CoV-2 Entry Inhibitors in the Respiratory Epithelium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orthopoxviruses;Rare Diseases;Tuberculosis

ORG_CITY: KINSHASA

ORG_COUNTRY: CONGO DEM REP

ORG_FIPS: CG

ORG_NAME: INSTITUT NATIONAL / RECHERCHE BIOMEDICAL

PHR: There is an urgent need to build a critical mass of well-trained research scientists, technicians, and logistics personnel who are prepared to confront endemic, emerging, and re-emerging infections in countries most affected by them, such as DRC. Given the EREP-RTP-DRC team’s scientific pedigree and extensive past and present experience in pandemic response, trainees will have unique opportunities to conduct mentored-research projects of local and global significance and high clinical and/or public health impacts while advancing their career paths. A broad range of expertise will be needed, to include genomics and bioinformatics, immunology/vaccinology, vector biology, epidemiology and biostatistics, clinical trials, implementation science, behavioral sciences, laboratory techniques, grant and scientific writing, and research grant administration.

PI_NAMEs: DE OLIVEIRA, TULIO DE PAIVA NAZARETH ANDRADE;MUYEMBE-TAMFUM, JEAN-JACQUES TAMFUM (contact);RIMOIN, ANNE WALSH;SULLIVAN, NANCY JEAN

PROJECT_TERMS: Address;Advisory Committees;Belgium;Biomedical Research;Boston;California;career development;Clinical;clinical practice;Collaborations;Consultations;COVID-19;Democratic Republic of the Congo;Development Plans;Doctor of Philosophy;Drug resistance in tuberculosis;Ebola;Ebola Hemorrhagic Fever;Educational workshop;Emerging infection;emerging pathogen;European;Evaluation;Fellowship;global health;Health Policy;innovation;Institution;Internships;Laboratories;Los Angeles;Mentors;Modeling;Monitor;Monkeypox;next generation;outbreak control;Outcome;Postdoctoral Fellow;Productivity;programs;Public Health;Readiness;recruit;Research;Research Ethics;Research Methodology;Research Project Grants;Research Training;Scientist;skill acquisition;skills;South Africa;Testing;Time;Training;Training Programs;Translating;Tropical Medicine;Universities;Writing

PROJECT_TITLE: Emerging and Re-Emerging Pathogens Research Training Program in DRC (EREP-RTP-DRC)


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE Cancer treatment-related adverse outcomes include premature/accelerated frailty and neuromuscular decline, the occurrence of which are increasing in the ever-growing pediatric cancer survivor population. Our proposal will use a murine model of multimodal pediatric cancer treatment to test the role of genotoxic stress regulated Growth Differentiation Factor 15, and the protooncogene receptor tyrosine kinase Ret in the regulation of intramuscular fibrosis and neuromuscular decline that burdens pediatric cancer survivors.

PI_NAMEs: CHAKKALAKAL, JOE  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Acceleration;Achievement;Acute;Address;Adolescent;Adverse effects;adverse outcome;Affect;Age;Animals;Attenuated;biological adaptation to stress;Biological Process;Body Weight;Body Weights and Measures;Brain Stem;cadherin 5;cancer cell;Cancer Patient;Cancer Survivorship;cancer therapy;Cell Count;Cells;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;childhood cancer survivor;Childhood Cancer Treatment;Chronic;Combined Modality Therapy;Data;Development;Diagnosis;Eating;Elderly;Endothelial Cells;Event;Feeding behaviors;Fibrosis;Flow Cytometry;fractionated radiation;frailty;GDF15 gene;Gene Expression;Gene Expression Profiling;Genes;Genotoxic Stress;Goals;Growth;Heterozygote;High Prevalence;Hindlimb;Hormones;Image;image guided;Impairment;Implant;improved;indexing;Individual;inducible Cre;inhibitor;insight;Intervention;Intramuscular;Knock-out;Knockout Mice;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medical;Mesenchymal Stem Cells;Microscopy;middle age;Morbidity - disease rate;mouse genetics;mouse model;multimodal modeling;multimodality;Mus;Muscle;Muscle Fibers;neuromuscular;neuromuscular function;Neuromuscular Junction;Neurons;Normal tissue morphology;novel;Pharmacological Treatment;Phenotype;Population;premature;Production;Proto-Oncogenes;Publishing;Radiation;radiation during childhood;radiation effect;Receptor Protein-Tyrosine Kinases;Regulation;Regulatory Element;Reporter;Research;response;Rhabdomyosarcoma;Roentgen Rays;Role;Science;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Stress;stressor;Survival Rate;Survivors;Tamoxifen;Testing;Therapeutic;TP53 gene;transcriptome sequencing;Transfection;Treatment-Related Cancer;tumor eradication;Vascular Endothelium;Vincristine;Weight Gain;x-ray irradiation;young adult

PROJECT_TITLE: Cellular basis for cancer treatment related GDF15 expression and the regulation of skeletal muscle fibrosis and neuromuscular integrity.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (05)]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Trauma is the leading cause of death in children. Severe traumatic brain injury (TBI) is the most important component of this mortality and associated morbidity. A specific therapy for TBI does not yet exist and standard treatment remains supportive in nature. This project will identify role of oxidized phospholipids in neuronal death after pediatric TBI using state of the art oxidative lipidomics approach. We will test novel therapeutic compounds in experiments to prevent neuronal death, improve outcome after pediatric TBI. The ability to selectively modulate this pathway could lead to targeted therapies for TBI and ultimately improve outcome for children.

PI_NAMEs: BAYIR, HÜLYA  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acids;Acute;Acyltransferase;adduct;Adult;Affinity;Anti-Inflammatory Agents;Antioxidants;Apoptotic;Arachidonate 15-Lipoxygenase;Arachidonic Acids;baicalein;Biochemical Reaction;Brain;Brain Injuries;Cardiolipins;catalyst;Cause of Death;Cessation of life;Child;Childhood Injury;Chronic;Clinical Trials;Coenzyme A Ligases;cognitive function;Collaborations;Complex;controlled cortical impact;cytochrome c;Data;design;drug discovery;Endoplasmic Reticulum;Enzymes;Esterification;Event;experimental study;Family member;Free Radical Scavengers;Free Radicals;Funding;Generations;Glutathione;glutathione peroxidase;Hospitalization;Hydrogen Peroxide;Hydrolysis;Hydroxides;Image;improved outcome;Induced Neurons;Induction of Apoptosis;Inflammatory Response;inhibitor;Injury;Innovative Therapy;Iron;Link;Lipid Peroxidation;lipidomics;Lipoxygenase Inhibitors;liquid chromatography mass spectrometry;Lysophosphatidylcholines;Mechanics;Membrane;Mitochondria;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;Nature;Neurological outcome;neuron apoptosis;neuron loss;Neurons;neuroprotection;new therapeutic target;novel therapeutics;oxidation;Oxidation-Reduction;Oxidative Stress;Pathogenicity;Pathway interactions;Pattern;pediatric traumatic brain injury;Peroxidases;peroxidation;Phosphatidylethanolamine;Phosphatidylethanolamine Binding Protein;Phospholipase;Phospholipids;postnatal;preference;preservation;prevent;protein complex;Proteins;Rattus;Reduced Glutathione;Role;Scaffolding Protein;Signal Transduction;small molecule;small molecule inhibitor;Source;standard care;Stretching;Substrate Specificity;Sulfhydryl Compounds;System;targeted treatment;TBI treatment;Technology;Testing;Therapeutic;Therapeutic Uses;Translations;Trauma;Traumatic Brain Injury;United States National Institutes of Health;Work

PROJECT_TITLE: Oxidative Lipidomics in Pediatric Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: Project Narrative Confirmation bias is a ubiquitous phenomenon that can lead to a variety of negative outcomes, including financial exploitation. Age-related differences in the function of the prefrontal cortex, coupled with deficits in cognitive processes like working memory and error detection, may leave older adults particularly susceptible to this bias and its harmful effects. Using computational modeling, noninvasive brain stimulation, and longitudinal methods, we aim to establish a clearer connection between confirmation bias and mild cognitive impairment that will provide insight into ways to mitigate its negative effects and protect older adults from fraud.

PI_NAMEs: WYNGAARDEN, JAMES  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Accounting;Address;age difference;age related;age related changes;age related cognitive change;age related deterioration;Age-associated memory impairment;Alzheimer's disease related dementia;Behavior;Behavioral;Belief;Brain;career;Cephalic;Cognitive;Cognitive deficits;cognitive function;cognitive process;Computer Models;Coupled;Detection;Deterioration;Diffusion;Educational workshop;Emotional;Exhibits;Feedback;financial exploitation;flexibility;follow-up;Fraud;Funding;Future;Goals;Grant;Impaired cognition;improved;Incidence;Individual;insight;Institution;Intervention;Investments;Judgment;Knowledge;Learning;Link;Literature;Measures;Mentorship;Methods;mild cognitive impairment;Modeling;Nature;neural;Neurobiology;Neurophysiology - biologic function;noninvasive brain stimulation;novel strategies;older adult;Outcome;Participant;Play;Population;Predisposition;Prefrontal Cortex;Process;Public Health;Questionnaires;Research Personnel;response;Risk;risk mitigation;Risk Reduction;Role;satisfaction;Shapes;Short-Term Memory;skills;social;Source;stem;Surveys;Techniques;Theta Rhythm;Time;tool;Training;transcranial direct current stimulation;Update;Visit;Work;young adult

PROJECT_TITLE: Characterizing the role of confirmation bias in financial exploitation of older adults


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Substance use disorders (SUDs) are debilitating and lack effective treatments. This proposal aims to explore the involvement of circadian rhythms in cholinergic interneurons and their potential link to addiction-like behaviors. By gaining a better understanding of the relationship between circadian rhythms and neural mechanisms underlying SUDs, we may improve current treatments or develop novel ones.

PI_NAMEs: STOWE, TAYLOR ASHLEY (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acetylcholine;Action Potentials;addiction;Address;Affect;Automobile Driving;Behavior;Body Temperature;Brain region;Cells;cholinergic;Chronic;circadian;Circadian Rhythms;Clinical Research;Cocaine;cocaine exposure;cocaine self-administration;Darkness;Data;Development;Diurnal Rhythm;Dopamine;Dose;DR1 gene;drug craving;Drug Exposure;effective therapy;Electrophysiology (science);Euthanasia;Exhibits;experience;Extinction;extracellular;Female;Frequencies;Hour;improved;Individual;insight;Intake;Interneurons;Learning;Light;Link;male;Measures;Mediating;Mediation;mesolimbic system;Molecular;molecular clock;motivated behavior;Motivation;Mus;Muscarinic Acetylcholine Receptor;Nature;neuromechanism;Neurons;Nicotinic Receptors;novel;Nucleus Accumbens;patch clamp;Pattern;Periodicity;personalized medicine;Persons;Pharmaceutical Preparations;Physiology;Play;Population;Predisposition;Prevalence;Process;Property;Public Health;Relapse;Research;response;Rewards;Risk Factors;Rodent Model;Role;Saline;Schedule;Self Administration;Sex Differences;Sleep disturbances;Slice;Source;Substance Use Disorder;Time;Training;Ventral Tegmental Area;Viral

PROJECT_TITLE: Rhythms in Cholinergic Interneuron Activity Mediate Drug-Taking  Behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE College drinking continues to be a major public health concern in the United States and a priority area within NIAAA. Research has examined how risky drinking is associated with alcohol-induced blackouts (AIBs), but not everyone who reports risky drinking will experience an AIB. The proposed research will measure risky drinking using transdermal alcohol concentration (TAC) sensors and will use a comprehensive theoretical model to examine predictors of AIBs.

PI_NAMEs: GLENN, SHANNON DELIA (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: absorption;Age;Alcohol consumption;alcohol exposure;alcohol risk;Alcoholic Intoxication;Alcohols;Area;Area Under Curve;Attitude;Behavior assessment;behavioral construct;binge drinking;Biological;Biometry;Biosensor;Birth;college drinking;Consumption;Data;Data Analyses;design;diaries;drinking;drinking behavior;Esthesia;Evaluation;Event;Expectancy;experience;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;falls;Female;Foundations;Frequencies;Future;Goals;Harm Reduction;high intensity drinking;high risk drinking;Individual;Informal Social Control;innovation;Intervention;Interview;Intoxication;male;Measures;Memory;Methods;Modeling;multimodality;National Institute on Alcohol Abuse and Alcoholism;novel;Participant;Patient Self-Report;peer;Persons;Pilot Projects;Predictive Value;protective behavior;Protocols documentation;prototype;psychosocial;Psychosocial Factor;Public Health;recruit;Reporting;Research;Risk;risk prediction;Sampling;Scientist;sensor;sex;skills;Speed;student drinker;student drinking;Students;Surveys;Theoretical model;Time;trait;United States;university student;willingness;Work;Wrist

PROJECT_TITLE: A daily diary study examining alcohol-induced blackouts among college students using alcohol sensors

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Tuberculosis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative Summary AIDS-related opportunistic neuro-infections of the brain are a common cause of death and disability in Sub-Saharan Africa as well as globally. This multidisciplinary training program focuses on research skills training for post-graduate physician-scientists from universities in Kampala and Mbarara in Uganda in collaboration with University of Minnesota faculty. This training program builds on a 17-year history of successful Ugandan and Minnesotan research partnerships which have impacted international HIV treatment guidelines related to diagnostics, treatment, and prevention of neuro-infectious diseases.

PI_NAMEs: BOULWARE, DAVID R (contact);MEYA, DAVID BISAGAYA

PROJECT_TERMS: Advisory Committees;Africa South of the Sahara;American;Appointment;Area;Biometry;career;Central Nervous System Infections;Clinical Research;Clinical Trials;Communication;Cryptococcal Meningitis;Data;Disease;Doctor of Philosophy;Educational workshop;Epidemiology;experience;Faculty;Fellowship;Funding;Future;HIV;Immunology;Interdisciplinary Study;Laboratories;Leadership;Manuscripts;Medical;Medical Residency;Medicine;Meningeal Tuberculosis;Meningitis;Mentors;Microbiology;Minnesota;Morbidity - disease rate;mortality;multidisciplinary;Neurology;Ophthalmology;Pharmacology;Physicians;Positioning Attribute;programs;Psychiatry;Publishing;randomized, clinical trials;Research;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Scientist;Secure;skills;Students;Teacher Professional Development;Training;Training Programs;Translational Research;Uganda;United States National Institutes of Health;Visit

PROJECT_TITLE: Minnesota-Makerere-Mbarara Neuro-Infectious Disease Research Training Consortium


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: PROJECT NARRATIVE The proposed conference is relevant to public health, since it will help advance metallodrug and metal-based radiopharmaceutical research for the development of more effective therapies and with fewer clinical problems than drugs currently used for the treatment of cancer, and infectious diseases. Thus, the findings are ultimately expected to be applicable to the health of human beings.

PI_NAMEs: ANDERSON, CAROLYN J. (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Academia;Address;Affect;Anti-Bacterial Agents;Anti-Infective Agents;Area;Basic Science;Binding;Biological;Biomedical Research;cancer therapy;career;Career Mobility;chelation;Chemoresistance;Clinical;clinical translation;Communicable Diseases;Companions;Complement;Complex;Cytoprotection;cytotoxic;Dedications;design;Detection;Developing Countries;Diagnosis;Diagnostic;disability;Discipline;Disease;disease model;Disparity population;diversity and inclusion;drug candidate;Drug Delivery Systems;effective therapy;empowerment;Ethnic Origin;Fertilization;Fostering;Funding;Future;graduate student;Growth;Health;health disparity;Hour;Human;human disease;Image;imaging agent;improved;Individual;Industrialization;innovation;Inorganic Chemistry;International;Ions;macromolecule;Medical;Medicine;meetings;Mental Health;Mentors;metal complex;Metals;Mission;next generation;novel;Oral;Participant;Pathologic;Pharmaceutical Preparations;Play;Postdoctoral Fellow;posters;Preparation;Process;Public Health;Race;Radiation Protection;Radioisotopes;Radiopharmaceuticals;recruit;Research;research and development;Research Personnel;Role;Science;Scientist;Stimulus;Students;symposium;targeted treatment;theranostics;Therapeutic;Tissues;Toxic effect;Treatment Efficacy;tumor;Underrepresented Populations;United States National Institutes of Health;Visit;Woman

PROJECT_TITLE: 2024 Metals in Medicine Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (J1)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Nutrition;Sleep Research

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE Disorders of sleep regulation frequently occur in individuals with disorders of metabolism such as diabetes mellitus, but the relationship between the two is not understood. Our research focuses on reactive oxygen species as a potential mechanism in the conserved salt-inducible kinase 3 pathway that link sleep regulation with metabolic regulation.

PI_NAMEs: MCINTIRE, PEARSON  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Amerindian;Animals;Antioxidants;Behavior;Behavioral;Biological Models;Caenorhabditis elegans;Communication;Communities;comorbidity;Cyclic AMP;Deacetylase;Diabetes Mellitus;Drug Metabolic Detoxication;Epidermal Growth Factor;Exhibits;Fatty acid glycerol esters;fatty acid oxidation;fly;Future;Generations;Genetic;Genetic Induction;Genetic study;genetic variant;genome wide association study;Glutamates;Goals;Histones;Homologous Gene;Human;Hypertriglyceridemia;in vivo;Individual;Insulin Resistance;Link;Lipase;lipid metabolism;loss of function;Mammals;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mexican;Mitochondria;model organism;Modeling;Molecular;Muscle;mutant;Nematoda;Neuroglia;Neurons;Neuropeptides;Obesity;optogenetics;Organism;overexpression;Paraquat;Pathway interactions;Peripheral;Phenotype;Phosphorylation;Phylogenetic Analysis;pressure;Production;Proteins;Proteomics;Reactive Oxygen Species;Regulation;Research;Resistance;Role;salt-inducible kinase;Signal Pathway;Signal Transduction;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep regulation;Sleeplessness;SOD2 gene;supernova;Superoxide Dismutase;Testing;Therapeutic;Tissues;tool;Triglycerides;Work

PROJECT_TITLE: ROS as a somnogenic signal in the metabolic regulation of sleep

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Myofibroblasts are a key regulator of tendon healing as they synthesize and remodel the new extracellular matrix. However, proper resolution of healing requires myofibroblast clearance via apoptosis or reversion to a basal fibroblast state. Here we will test the efficacy of small molecule activation of Gpr68 as a means to modulate myofibroblast differentiation and reversion and enhance the tendon healing process.

PI_NAMEs: KOTTMANN, ROBERT MATTHEW;LOISELLE, ALAYNA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Actins;Apoptosis;Apoptotic;Articular Range of Motion;Attenuated;Blood Vessels;cell type;Cells;Chronic;Cicatrix;Clinical;Complex;conditional knockout;Contracts;cost;Data;Down-Regulation;efficacy testing;Environment;Extracellular Matrix;Fibroblasts;Fibrosis;G-Protein-Coupled Receptors;Genetic;healing;high reward;high risk;Homeostasis;Human;idiopathic pulmonary fibrosis;Impairment;improved;in vivo;Incidence;Inferior;Injury;injury and repair;Knockout Mice;Knowledge;Lung;Macrophage;Mechanics;Mediating;mouse model;Mus;Myofibroblast;novel;Operative Surgical Procedures;Orthopedic Surgery;Outcome;Pathology;pharmacologic;Phenotype;Physiological;Population;prevent;Process;Production;programs;Protons;Recovery of Function;Regulation;repaired;Resolution;response;restoration;Role;Rupture;Signal Transduction;small molecule;Smooth Muscle;Tendon Injuries;Tendon structure;Testing;Therapeutic;therapeutic target;Time;Tissues;Transforming Growth Factor beta;Transgenic Mice;treatment duration;Work;wound healing

PROJECT_TITLE: Gpr68 modulation of myofibroblast dynamics during tendon healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (03)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Mental Health;Nutrition;Social Determinants of Health

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Type 1 diabetes is an exceptionally difficult disease to manage, requiring life-long adherence to a complex, daily disease management regimen in order to manually regulate one’s blood glucose. While psychosocial influences of blood glucose are widely known, research in this area is constrained by a focus on broad cross- sectional or between-person effects. The proposed research will investigate granular, within-day links of psychosocial factors to short-term blood glucose outcomes, thus furthering our understanding of how these processes unfold in real-time and paving the way for future just-in-time interventions to improve diabetes management.

PI_NAMEs: HORNER, FIONA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adherence;Adult;Affect;Area;Attention;barrier to care;Behavior;Behavioral;Blood Glucose;blood glucose regulation;Buffers;burden of illness;career;Caring;Collaborations;Complex;Continuous Glucose Monitor;cost;Data;design;Devices;diabetes distress;diabetes management;Diabetes Mellitus;Diagnosis;digital health;Disease;Disease Management;Disease Outcome;Disease Progression;Distress;Dose;Eating;Ecological momentary assessment;Emotional;emotional experience;Endocrine;Energy Metabolism;Environment;experience;Factor Analysis;Female;Future;Gender;gender difference;Glucose;Glycosylated hemoglobin A;Grain;Health;Hour;improved;innovation;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Investigation;Knowledge;Life Change Events;Link;Literature;male;Manuals;Maps;Measures;Mediating;Mediator;Mentorship;Methods;monitoring device;Moods;Morbidity - disease rate;mortality;negative affect;negative mood;Neurosecretory Systems;Outcome;Participant;Pathway interactions;Patients;Persons;Physiological;Play;positive mood;Principal Investigator;Process;programs;psychologic;psychosocial;Psychosocial Factor;Psychosocial Influences;Regimen;repetitive behavior;Reporting;Research;Research Personnel;Role;Self Care;social;Social Interaction;social relationships;Stress;Surveys;System;Technical Expertise;Time;Training;training opportunity;Variant;wearable device;Work

PROJECT_TITLE: Time-varying psychosocial influences of blood glucose among adults with type 1 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Engagement in cognitively effortful activities is thought to be important for the maintenance of cognitive function and resilience to age-related pathology, however, despite the potential importance of engaging in cognitively effortful activities, older adults actually report decreased participation in these types of activities in daily life. This project will provide critical and detailed information regarding the behavioral and neurobiological mechanisms of daily life activity participation in older adults and its relationship to Alzheimer’s disease pathology. Such information has clear relevance for public health, by improving understanding of how and why aging might lead to a motivational shift that contributes to changes in activity participation, and in developing appropriate interventions to address such changes.

PI_NAMEs: CRAWFORD, JENNIFER L. (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;age related;age related changes;Age related pathologies;Aging;Alzheimer's Disease;Alzheimer's disease pathology;amyloid pathology;Behavioral;Behavioral Mechanisms;behavioral study;Binding;Biological;Catecholamines;Cognitive;cognitive ability;cognitive enhancement;cognitive function;cognitive load;cognitive neuroscience;Corpus striatum structure;cost;Coupled;discounting;Dopamine;Ecological momentary assessment;Exertion;experience;Foundations;Health;human old age (65+);improved;in vivo;Incentives;indexing;Individual Differences;innovation;Intervention;Investigation;Life;Link;locus ceruleus structure;Maintenance;Measures;medial temporal lobe;Methods;middle age;mobile computing;Monitor;Motivation;motivational intervention;multimodality;neurobiological mechanism;Neurobiology;neuroeconomics;neuroimaging;neuroregulation;Norepinephrine;novel;older adult;Pathology;Physiological;Positron-Emission Tomography;Predisposition;preservation;Process;promote resilience;Protocols documentation;Psychophysiology;public health relevance;Reporting;Research;resilience;Risk;Role;Sampling;sensor technology;Structure;Support System;System;tau Proteins;Temporal Lobe;Testing;tool;Tyrosine;Work;young adult

PROJECT_TITLE: Neurobiological mechanisms of daily life activity participation in older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Human Genome;Organ Transplantation;Transplantation

PHR: Project Narrative Myxomatous valve disease and associated mitral valve prolapse affects 2-3% of the population, but the molecular and cellular mechanisms that underlie it remain unknown. Our preliminary studies reveal that blood flow and the flow-regulated transcription factors KLF2 and KLF4 in valve endothelial cells are required to maintain healthy heart valves and prevent myxomatous valve pathology in mice. This proposal will investigate the role of blood flow and KLF2/4 function in valve homeostasis and myxomatous valve pathogenesis.

PI_NAMEs: PACE, JESSE  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Abdomen;Adult;Affect;Age;Alleles;ATAC-seq;Blood flow;Cardiac;Cell Nucleus;Cell Separation;cell type;Cleavage Under Targets and Release Using Nuclease;Coronary artery;Data;Development;differential expression;Disease;Endothelial Cells;Endothelium;Environmental Risk Factor;Exhibits;Extracellular Matrix;Gene Mutation;Genes;Genetic;Heart;Heart Transplantation;Heart Valve Diseases;Heart Valves;hemodynamics;Hemorrhage;Homeostasis;Human;interstitial cell;Life;LoxP-flanked allele;MADH7 gene;Marfan Syndrome;Medical;Mitral Valve;Mitral Valve Prolapse;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;neutralizing antibody;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Perfusion;Persons;Phenotype;Population;preservation;Prevalence;prevent;Proliferating;Ptosis;Research;Role;role model;Signal Transduction;single-cell RNA sequencing;Syndrome;TGFBR1 gene;transcription factor;transcriptome sequencing;transplant model;Transplantation

PROJECT_TITLE: Hemodynamics and KLF2/4 regulate myxomatous valve pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Cerebral small vessel disease (CSVD) is a significant aspect of pathology in Vascular Contributions to Cognitive Impairment and Dementia (VCID) and Alzheimer's disease (AD), and changes in white matter structure and functional connectivity resulting from CSVD may be potential biomarkers in the preclinical stages of both diseases. As disease prevalence differs for men (higher for VCID) and women (higher for AD), sex as a biological factor needs to be considered. This project will examine CSVD-related neuroimaging biomarkers and cognitive data in women and men with mutations leading to preclinical VCID and AD, with the aim of identifying sex-specific patterns of neurodegeneration to enable tailored interventions, sex-specific preventative strategies, and improved diagnostic accuracy for both men and women.

PI_NAMEs: GIUDICESSI, AVERI JORDIN (contact)

PROJECT_TERMS: abeta accumulation;Accounting;Adult;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;amyloid formation;amyloid pathology;Anisotropy;Arterial Disorder;Automobile Driving;autosomal dominant mutation;autosome;Blood Vessels;Brain;cardiovascular risk factor;career;cerebral microbleeds;Cerebral small vessel disease;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Clinical;Cognitive;cognitive function;cognitive performance;cohort;Consensus;Data;Dementia;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic accuracy;Disease;Disease Outcome;Disproportionately impacts women;Early Diagnosis;early onset;Elderly;executive function;Exhibits;familial Alzheimer disease;Female;Functional Magnetic Resonance Imaging;Future;Gender;Genetic Models;Graph;human old age (65+);Hypertension;Impaired cognition;Impairment;improved;Individual;Inherited;Intervention;Knowledge;male;Measures;Medial;men;middle age;Modeling;Mutation;mutation carrier;Nerve Degeneration;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;neuroimaging;neuroimaging marker;Neurologic;older adult;Older Population;Outcome;pathological aging;Pathology;Pathway Analysis;Pattern;Performance;potential biomarker;pre-clinical;predictive marker;presenilin-1;Prevalence;prevent;Prevention strategy;Process;Reproductive History;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;segregation;Senile Plaques;sex;sex as a biological variable;Sex Differences;Structure;Subcortical Infarctions;Subcortical Leukoencephalopathy;success;tau Proteins;Testing;Therapeutic;Training;vascular cognitive impairment and dementia;Vascular Dementia;vascular factor;white matter;White Matter Disease;White Matter Hyperintensity;Woman

PROJECT_TITLE: Examining Sex-Specific Effects on White Matter Integrity and Brain Function in Familial Alzheimer's Disease and Vascular Dementia


ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: Project narrative Peroxisomes are essential organelles in multicellular organisms that house oxidative reactions, such as fatty acid β-oxidation, and antioxidative enzymes that detoxify reactive oxygen species. Despite the importance of peroxisomes, peroxisomal turnover (or pexophagy), a critical aspect of organelle proteostasis, remains poorly understood. The goal of this project is to identify and characterize environmental conditions and proteins involved in pexophagy.

PI_NAMEs: JACKSON, MAKAELA  (contact)

PROJECT_TERMS: Agriculture;Autophagocytosis;Autophagosome;Binding;Biogenesis;Cells;Cellular biology;Color;Confocal Microscopy;Cytosol;Darkness;design;Drug Metabolic Detoxication;Enzymes;Essential Fatty Acids;Fatty Acids;Fluorescence;Fluorescence Microscopy;Goals;Home;Human;Impairment;improved;Knowledge;Lipase;Literature;loss of function;Lytic;Mammals;Mechanics;Mediating;Membrane;Metabolic;metabolic engineering;Metabolism;Molecular Chaperones;Monitor;Mouse-ear Cress;mutant;Nitrogen;Nutrient;Organelles;Organism;oxidation;Oxidative Stress;Oxygen;Peptide Hydrolases;Peroxisomal Disorders;peroxisome;Physiological Processes;Plants;Process;Protein Import;Proteins;proteostasis;Reaction;Reactive Oxygen Species;receptor;receptor recycling;Recycling;Regulation;Reporter;Role;Seedling;Shapes;Starvation;Stimulus;Stress;Testing;tool;ubiquitin-protein ligase;Ubiquitination;Vacuole;Visualization;Western Blotting;Yeasts

PROJECT_TITLE: Investigating the role of autophagy inducers and peroxisomal proteins in pexophagy


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Not applicable

PI_NAMEs: WU, YALAN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Medical;programs;Scientist;Training;United States National Institutes of Health

PROJECT_TITLE: Medical Scientist Training in the NIH Partnership Program - Yalan Wu

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-U (22)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative: Tau abnormalities are causal for neurodegeneration in Alzheimer’s Disease (AD) and AD-related dementias (ADRDs), but how they arise is unclear. Here, we will test the hypothesis that the six-transmembrane GPI-anchor cleaving enzyme, GDE2, regulates GPI-anchored mediated pathways to regulate post-translational modifications of tau that are relevant to disease. Outcomes from this study could help elucidate pathways relevant to disease pathogenesis and could identify novel targets for therapeutic intervention.

PI_NAMEs: JIMENEZ-ORNELAS, CONSUELO  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Acetylation;Address;Affect;ALS patients;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloidosis;Animals;Antibodies;APP-PS1;Autophagocytosis;Autopsy;Biochemical;Brain;Cell Compartmentation;Cell surface;Cells;Cerebrospinal Fluid;Coupled;cysteine rich protein;Cytoskeleton;Disease;Enzymes;Exhibits;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;genome wide association study;glycerophosphodiester phosphodiesterase;Glypican;GPI Membrane Anchors;Hippocampus;Homeostasis;Human;hyperphosphorylated tau;Immunohistochemistry;Impairment;In Vitro;in vivo;Individual;Induced Neurons;insight;Integral Membrane Protein;Laboratories;Link;Measures;Mediating;Membrane;Microtubule-Associated Proteins;Mitochondria;mitochondrial dysfunction;Modeling;Modification;mouse model;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;Neuronal Dysfunction;Neurons;new therapeutic target;Outcome;Outcome Study;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phosphorylation;Physiological;protein distribution;protein function;Proteins;Proteomics;proteostasis;Publishing;Regulation;Role;Signal Pathway;Silver Staining;Structure;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic Intervention;Time;Tissues;Vertebrates;Virus

PROJECT_TITLE: Investigating physiological pathways modulating tau homeostasis: potential implications for Alzheimer's Disease and Related Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chronic stress in adolescence alters how the brain processes rewards later in life, biasing individuals towards addictive-like behaviors. However, the specific changes induced by stress remain unknown. This project will answer fundamental questions about how stress in adolescence alters a circuit projecting from the amygdala to midbrain dopamine neurons, suggesting a potential focus for treatment and prevention of addictive disorders.

PI_NAMEs: NADEL, JACOB ANDREW (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Adverse event;Affect;Amygdaloid structure;Animals;Attenuated;Behavior;Behavioral;Biological;Brain;Calcium;career;Cell Nucleus;Cells;Chronic;Chronic stress;cohort;Communication;compulsion;Compulsive Behavior;Corpus striatum structure;COVID-19 pandemic;critical period;Data;Development;Disease;Disinhibition;Dopamine;dopaminergic neuron;Drug abuse;Drug Addiction;Educational process of instructing;Electrophysiology (science);experience;experimental study;Exposure to;Extinction;Fellowship;Fiber;Foundations;gamma-Aminobutyric Acid;Genetic;Goals;Grant;heavy nuclei;Human;Hyperactivity;In Vitro;in vivo;Individual;Interneurons;Intervention;Knowledge;Lateral;Lead;Life;Link;Maintenance;Mediating;Mental disorders;Midbrain structure;Mus;National Institute of Drug Abuse;neural;neural circuit;neuroadaptation;neuromechanism;Neurons;nonhuman primate;Operant Conditioning;Optics;Organism;Outcome;patch clamp;Pathway interactions;Patient Self-Report;Pattern;Phase;Photometry;Physiological;Positioning Attribute;Precipitating Factors;Prevention;Process;Property;Punishment;Research Personnel;Resistance;response;Rewards;Risk Factors;Rodent;sensor;Stress;Substantia nigra structure;symposium;Synapses;Tail;Technical Expertise;Testing;Therapeutic Intervention;therapeutic target;Time;Training;training opportunity;translational therapeutics;Writing

PROJECT_TITLE: The impact of adolescent stress on neural circuits underlying punishment resistant reward seeking


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The factors affecting natural killer (NK) cells’ antibody-dependent responses to COVID-19 are not yet clear. This proposed work will investigate the impact COVID-19 vaccination and infection, immunosuppressant drugs, and contact with SARS-CoV-2-infected cells have on NK cells’ antibody-dependent responses using COVID-19 clinical samples and replication-competent SARS-CoV-2. These experiments will provide crucial insights into how vaccination and therapeutic strategies should seek to enhance NK cells’ antibody-dependent responses to COVID-19.

PI_NAMEs: CHAN, LESLIE  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Affect;Antibodies;antibody-dependent cell cytotoxicity;Antigens;antiviral immunity;Area;breakthrough infection;Cell Physiology;Cell Separation;Cell surface;Cells;Cellular Stress;Certification;Charge;Classification;Clinical;Coculture Techniques;Communicable Diseases;Confocal Microscopy;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 vaccination;Creativeness;cytokine;Cytomegalovirus;cytotoxic;Data;Disease;Disease Outcome;Drug Interactions;Effector Cell;engineered NK cell;experience;experimental study;Goals;Human;Immune;Immune response;Immunocompetent;Immunocompromised Host;Immunosuppression;Immunosuppressive Agents;Impairment;Incidence;Individual;Infection;insight;interest;Knowledge;Ligands;Mass Spectrum Analysis;Mediating;Memory;Mus;Natural Killer Cells;neoplastic cell;neutralizing antibody;novel;overexpression;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phosphorylation;Process;Proteins;Proteomics;Public Health;Qualifying;Research;response;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 variant;severe COVID-19;Shapes;Signal Transduction;Signaling Molecule;Surface;System;Testing;Therapeutic;tool;Training;Transfection;Vaccination;Vaccinee;Variant;Virus;Visualization;Work

PROJECT_TITLE: Defining factors affecting natural killer cells' antibody-dependent responses in COVID-19


ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: The proposed project addresses the physiological role of the astrocytic inwardly rectifying potassium channel Kir4.1 and how it modulates interneuron activity in the cerebral cortex. This channel has been implicated in a variety of neurological disorders including seizure susceptibility, epilepsy, and ALS; however, how it affects neuronal function is unknown. If successful this project will provide a better understanding of potassium homeostasis, interneuron activity, and astrocytic potassium buffering and how these contribute to pathology.

PI_NAMEs: ARMBRUSTER, MORITZ  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Action Potentials;Address;Affect;Area;Astrocytes;Automobile Driving;Biological Assay;Brain;Buffers;Cerebral cortex;Characteristics;Data;Dependence;Electrophysiology (science);Epilepsy;excitatory neuron;extracellular;fluorescence imaging;Frequencies;gamma-Aminobutyric Acid;hippocampal pyramidal neuron;Homeostasis;Hyperactivity;Image;imaging approach;In Vitro;in vitro Model;insight;Interneurons;Investigation;inward rectifier potassium channel;Measures;Mediating;Modeling;Mutation;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neuronal excitability;Neurons;neurotransmitter release;Neurotransmitters;novel;Output;overexpression;Parvalbumins;Pathologic;Pathology;Pathway interactions;Physiological;Play;Potassium;Predisposition;presynaptic;presynaptic neurons;restraint;Role;Runaway;Seizures;Signal Transduction;Site;Sleep Wake Cycle;Somatostatin;Source;spreading depression;Synapses;synaptic function;Testing;voltage

PROJECT_TITLE: Extracellular potassium and astrocytic Kir4.1 modulate interneuron activity in the cerebral cortex

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_DEPT: DENTISTRY

PHR: Project Narrative Amelogenin is the major protein in forming enamel and its mutations cause severe enamel disease – X-linked Amelogenesis Imperfecta (AI). Acid phosphate 4 (ACP4) which also plays essential roles in enamel formation and its mutations cause recessive AI. Using molecular biology and bioinformatic approaches we found that ACP4 expression in mice lacking phosphorylated amelogenin is increased, suggesting interactions between these proteins. This proposal focuses on studies of these interactions.

PI_NAMEs: VASQUEZ, BRENT PRESTON (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acid Phosphatase;Acids;Active Sites;Affect;Ameloblasts;Amelogenesis;Amelogenesis Imperfecta;amelogenin;Apatites;Bioinformatics;Biological Assay;Biology;calcification;calcium phosphate;Cell Line;Cell Lineage;Cells;Co-Immunoprecipitations;Confocal Microscopy;Crystal Formation;Data;Dental Enamel;Dental Enamel Hypoplasia;design;Development;Disease;Distal;Embryo;Enamel Formation;Enamel Organ;Environment;Enzymes;Exhibits;experimental study;Exposure to;extracellular;Extracellular Domain;Extracellular Matrix Proteins;Family suidae;Genotype;Golgi Apparatus;Human;Immunofluorescence Immunologic;Immunohistochemistry;In Situ;In Vitro;in vivo;Incisor;Individual;inorganic phosphate;insight;Integral Membrane Protein;kidney cell;Knock-in Mouse;Knowledge;Ligation;Link;Lysosomes;Membrane;Molecular Biology;mouse model;Mus;Mutation;Pathology;Pathway interactions;Patients;Phase;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Plasmids;Play;prevent;Process;protein protein interaction;Proteins;Publications;Publishing;Reporting;Resolution;Rod;Role;single-cell RNA sequencing;Stains;Structure;Testing;Tissue-Specific Gene Expression;Tissues;Tooth structure;Transfection;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Investigating Interactions Between Phosphorylated Amelogenin and Acid Phosphatase 4 Expression

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative  Increased mental health issues related to the COVID-19 pandemic, long wait times in emergency rooms for inpatient psychiatric services, a shortage of mental health providers, and increased calls to the new “988” number for the National Suicide Prevention Lifeline have combined to underscore the unmet need for mental health crisis services in United States. Mobile Crisis Units- teams that de-escalate and triage individuals in psychiatric crisis in the community- are a service that may help to meet this need, given a sufficient workforce. This project will determine how Illinois lawmakers can optimize the policies they have enacted to grow that workforce, first by gathering qualitative data from stakeholders and quantitative data from policy evaluation, and then by combining these data to simulate the effects of policy changes on the workforce.

PI_NAMEs: FINE, JEREMY DAVID (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Accident and Emergency department;Address;Adoption;Affect;burnout;Caring;Certification;Client;Clinical;Collaborations;Communities;Complex;Congresses;COVID-19 pandemic;Data;data sharing;design;dynamic system;Employment;Ensure;Ethics;Evaluation;evidence base;experience;Goals;Government Officials;Guidelines;health care settings;Health Personnel;Health Professional;Healthcare;Heart;hospital bed;Hospitalization;Human;Human Resources;Illinois;improved;Individual;Infrastructure;innovation;Inpatients;Laws;Lead;Lived experience;Maps;Medical;meetings;Mental disorders;Mental Health;Mental Health Services;Methods;model building;Modeling;models and simulation;National Institute of Mental Health;Outcome;Patient-Centered Care;Patients;peer;peer support;Persons;Policies;Policy Analysis;Policy Maker;policy recommendation;Population;Positioning Attribute;prevent;programs;Provider;psychiatric inpatient;Psychiatry;Qualifying;Quality of Care;Recommendation;Recovery Support;referral services;Regression Analysis;Research;Resources;response;Risk;Rotation;Service delivery model;Services;Specialist;stakeholder perspectives;State Government;Statutes and Laws;success;Suicide;Suicide prevention;System;Techniques;Telephone;Testing;Thinking;Training;Triage;United States;United States Substance Abuse and Mental Health Services Administration;Universities;Violence;Wait Time;Work;workforce needs;Workload

PROJECT_TITLE: Mobile Crisis Workforce Pipeline: Meeting the Needs of Illinois

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: OMAHA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative This population study is centered on advancing our knowledge of exclusive ENDS use (vs. no tobacco use) in youth brain structure (Aim 1) and cognitive performance (Aim 2) as well as relative effects of exclusive ENDS use and cigarette smoking on brain health (Aim 3). Identifying the health effects of ENDS use on brain maturation is critical to informing effective regulatory actions and policies including making decisions about the potential risks of ENDS to public health.

PI_NAMEs: BENOWITZ, NEAL L;DAI, HONGYING DAISY (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: 10 year old;18 year old;Adolescence;Adolescent;Adverse effects;Aerosols;Age;aged;Animal Model;Attention;behavior measurement;Behavioral;Brain;brain health;Chemicals;Child;Child Health;Childhood;Cigarette;cigarette smoking;Cognition;Cognitive;cognitive ability;cognitive development;cognitive function;cognitive performance;combustible cigarette;critical period;Data;Decision Making;Development;electronic cigarette use;Electronic Nicotine Delivery Systems;Electronics;emotion regulation;Epidemic;Etiology;executive function;follow-up;Formulation;Frequencies;Functional Magnetic Resonance Imaging;Generations;Goals;gray matter;Health;high school;Human;improved;Inferior;innovation;interest;Intervention;junior high school;Knowledge;Learning;Link;longitudinal analysis;longitudinal dataset;Magnetic Resonance Imaging;Marketing;Measures;Memory;Modernization;Neurocognition;Neurocognitive;neurotoxicity;Nicotine;nicotine exposure;novel;Outcome;Participant;Policies;Population;Population Study;Prefrontal Cortex;programs;prospective;Public Health;Public Policy;public policy on tobacco;Reporting;reward processing;Risk;Rodent;Sales;Site;Smoker;Smoking;Sodium Chloride;Statistical Models;Structural Models;Structure;Students;Testing;Thick;Time;Tobacco;Tobacco smoke;Tobacco smoking behavior;Tobacco use;tobacco user;Toxin;United States Food and Drug Administration;United States National Institutes of Health;vaping;Youth

PROJECT_TITLE: Health Effects of E-cigarette Use on Brain Functions and Cognitive Development among Adolescents: A US Population-Based Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (J1)]


NIH_SPENDING_CATS: Arthritis;Genetics;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Decades of post-traumatic osteoarthritis (PTOA) research have focused on the degeneration of musculoskeletal tissues such as the bone and cartilage but have not yet yielded effective treatments. Pathologic fibrosis of the synovia is increasingly recognized as a driver of pain and disease progression in PTOA, and our preliminary evidence supports the role of the mechanosensitive Piezo1 ion channel in mediating this fibrotic remodeling. This study aims to characterize the molecular pathway utilized by synovial fibroblasts through which Piezo1 transduces the fibrotic synovial microenvironment to drive disease progression.

PI_NAMEs: FARRELL, EASTON  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Ablation;Activities of Daily Living;Acute;Agonist;Automobile Driving;AXIN2 gene;beta catenin;Bioinformatics;Biological Process;bone;Bone remodeling;Bone Spur;Calcium;Calcium ion;Cartilage;Cell membrane;Cell Nucleus;Cells;Chronic;Clinical;combat;Data;Degenerative polyarthritis;Deposition;disability;Disease Progression;Doctor of Philosophy;doctoral student;effective therapy;Evaluation;Event;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Fibrosis;gain of function;Gel;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Histologic;Human;Image;Immune;In Vitro;in vivo;Incubated;Inflammation;Inflammatory;inhibitor;Ion Channel;joint injury;Joints;Knockout Mice;loss of function;Measures;Mechanical Stimulation;Mechanoreceptors;mechanotransduction;Mediating;Mediator;Membrane;Molecular;mouse model;Mus;Musculoskeletal;Myofibroblast;novel therapeutics;Nuclear Translocation;Pain;Pathogenesis;Pathologic;Pathway interactions;Pattern;Peptide Hydrolases;Periodicity;pharmacologic;Phenotype;Population;Pre-Clinical Model;Production;progenitor;Proliferating;protein expression;Proteins;Publishing;ratiometric;Regulation;Research;Research Personnel;Role;Severities;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;subchondral bone;Synovial Fluid;Synovial Membrane;Synovitis;Testing;therapeutic target;Time;Tissues;Transcript;transcription factor;transcriptome;transcriptome sequencing;Traumatic Arthropathy;Traumatic injury;Up-Regulation;uptake;wound healing

PROJECT_TITLE: Piezo1-driven Synovial Fibrosis in Post-Traumatic Osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Salmonella enterica serovar Typhimurium, one of the most common causes of bacterial gastroenteritis, has a repertoire of secreted protein effectors that promote virulence. The effector SarA hijacks host gene expression but how this impacts oral infection is unknown. Through integrating biochemical, cellular, and mouse infection models, this proposed research will elucidate the signaling mechanisms of SarA and reveal how this effector shapes disease in the gut.

PI_NAMEs: GAGGIOLI, MARGARET RYAN (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Acute;acute infection;Anti-Inflammatory Agents;Bacteria;Bacterial Gastroenteritis;Binding;Biochemical;Cell Physiology;Cells;Characteristics;Chronic;co-infection;Colitis;comparative genomics;Complex;cytokine;cytokine receptor gp130;Data;Disease;enteric infection;Environment;experimental study;fitness;foodborne illness;foodborne pathogen;Functional disorder;functional genomics;Gastroenteritis;gastrointestinal;Gene Expression;Genes;Genetic Transcription;genomic data;Glycogen Synthase Kinase 3;gut inflammation;Hepatitis D;Human;IL6ST gene;ileum;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;Interleukin-6;Intestines;intraperitoneal;Invaded;Kinetics;knock-down;Knock-out;Liver;Measures;Mediating;Modeling;Molecular;mouse model;Mucosal Immune Responses;murine colitis;Mus;Mutagens;Mutate;Oral;oral infection;Outcome;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Production;programs;Protein Secretion;Proteins;receptor;Recombinant Interleukin-10;recruit;Research;RNA Interference;Role;Route;Salmonella;Salmonella enterica;Salmonella infections;Salmonella typhi;Salmonella typhimurium;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;Spleen;STAT protein;STAT3 gene;Stat3 Signaling Pathway;Systemic disease;Testing;Time;Tissues;transcriptome sequencing;Typhoid Fever;Up-Regulation;Vacuole;Virulence;Virulence Factors

PROJECT_TITLE: The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative This project aims to illuminate the role of alternative polyadenylation (APA) as a key post-transcriptional regulatory mechanism propelling prostate cancer towards its lethal stages. By delving into APA, we will enrich the existing comprehension of the transcriptional processes fueling prostate cancer progression. The prospective clinical implications of this research could revolutionize our approach, providing a foundation for novel APA-focused therapeutic strategies for prostate cancer.

PI_NAMEs: LI, WEI ;WANG, QIANBEN  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: 3' Untranslated Regions;Algorithms;androgen sensitive;Automobile Driving;Benign;Binding Proteins;Binding Sites;Bioinformatics;Biological Process;Cancer Patient;cancer type;Castration;Cell model;Cells;Classification;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Comprehension;Computer Models;Data;Data Set;efficacy evaluation;Engineering;epigenetic regulation;Event;Foundations;Gene Expression;gene function;Genes;genome sequencing;genome-wide;Growth;Human;improved;In Vitro;in vivo;Length;Link;Literature;Location;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Messenger RNA;Modeling;Molecular;mRNA Expression;mRNA Stability;mRNA Translation;multiple omics;Neuroendocrine Prostate Cancer;novel;Oncogenes;Outcome;patient stratification;Patients;Phase;Polyadenylation;Post-Transcriptional Regulation;posttranscriptional;Pre-mRNA Polyadenylation Factor;prospective;Prostate;Prostate Adenocarcinoma;prostate cancer cell line;prostate cancer progression;Prostate Cancer therapy;protein protein interaction;Proteins;Quantitative Trait Loci;Regulation;Reporting;Research;Resistance;ribosome profiling;Ribosomes;RNA;RNA-Binding Proteins;Role;Sampling;Single Nucleotide Polymorphism;Skin Cancer;System;Systems Biology;Technology;The Cancer Genome Atlas;Therapeutic;Tissues;Transcript;Transcription Process;Transcriptional Regulation;transcriptome sequencing;Translations;tumor;tumor progression;Tumor Suppressor Genes;whole genome

PROJECT_TITLE: Elucidating alternative polyadenylation regulation during prostate cancer progression to castration-resistance

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Nearly 30% of breast cancers progress to incurable metastatic disease, and drugs that block the actions of ribonucleotide reductase (RNR) are used to treat metastatic breast cancer but often cause unacceptable toxicities. This proposal focuses on determining if TMU27a, a newly developed type of RNR inhibitor, suppresses aggressive breast cancer growth and is less toxic than a commonly used drug, gemcitabine. Completing this project will provide a foundation for building new molecules based on TMU27a that can block RNR and are highly effective in the treatment of breast cancer without causing the toxicities associated with currently available RNR drugs.

PI_NAMEs: BRZOZOWSKI, TAYLOR LYNN (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;advanced breast cancer;advanced disease;Affinity;aggressive breast cancer;analog;Apoptosis;Binding;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;Breast Cancer Treatment;Cancer Cell Growth;Cancer Etiology;Cardiotoxicity;Catalysis;Catalytic Domain;Cell Death;Cell Line;Cell Membrane Permeability;Chromosomal Instability;combat;Cryoelectron Microscopy;Data;design;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA polymerase beta2;Docking;Dose Limiting;Drug Design;drug efficacy;Drug Kinetics;Drug usage;efficacy evaluation;efflux pump;enzyme activity;Enzymes;Evaluation;FDA approved;Foundations;Free Radicals;Future;gemcitabine;Genome Stability;Genomic Instability;Genomics;Growth;Hepatotoxicity;Holoenzymes;Human;Human Cell Line;human model;Hydrazones;improved;in silico;inhibitor;Lead;Leukocytes;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Metabolic;Metastatic breast cancer;Mitosis;Molecular;molecular dynamics;Mouse Cell Line;mouse model;Mus;Myelosuppression;Neoplasm Metastasis;novel;nucleoside analog;Nucleotides;Patient Care;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Population;pre-clinical;predictive modeling;Production;Recurrence;replication stress;Repression;Resistance;Resistance development;Ribonucleotide Reductase;Ribonucleotide Reductase Inhibitor;Ribonucleotide Reductase Subunit;Rodent Model;RRM1 gene;RRM2 gene;Safety;screening;senescence;Side;side effect;Specificity;Structure;Surface Plasmon Resonance;Survival Rate;Techniques;therapeutic target;three dimensional structure;Toxic effect;Treatment Failure;tumor;tumor growth;Up-Regulation;uptake;Weight;Women's mortality;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Ribonucleotide Reductase as a Driver of Breast Cancer Aggressiveness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Although there exists an efficacious surgical intervention for primary prevention of stroke resulting from carotid artery stenosis (CAS), a critical barrier to progress is the inability to identify which patients with CAS are going to have a stroke and would benefit from early surgery. Given the genetic exploration of CAS has been limited, this project aims to identify genes responsible for CAS causing stroke, develop a genetic score to stratify high risk patients for surgery, and provide novel opportunities for prevention and treatment of atherosclerosis in general toward reducing the risk of stroke.

PI_NAMEs: BELLOMO, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Angiography;Arterial Fatty Streak;Atherosclerosis;biobank;Blood flow;Blood Vessels;Brain;Carotid Artery Diseases;Carotid Stenosis;causal variant;Cause of Death;Cervical;Characteristics;Clinical;clinically significant;Code;cohort;Coronary Arteriosclerosis;Data;design;Diagnosis;disability;Disease;Disease Progression;Ensure;Etiology;Event;experience;Functional disorder;Funding;Future;General Population;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic study;genetic variant;genome wide association study;genome-wide;Goals;Grant;high risk;Human Genetics;Image;improved;International;Investigation;Ischemia;Ischemic Stroke;Knowledge;Lead;Massachusetts;Measurement;Medical;Medicine;Mentors;new therapeutic target;novel;Operative Surgical Procedures;patient population;Patient Selection;patient stratification;Patients;Peripheral arterial disease;Pharmaceutical Preparations;Phenotype;polygenic risk score;Polygenic Traits;Population;Positioning Attribute;prevent;Prevention;Preventive therapy;Primary Prevention;programs;Public Health;Publishing;Reporting;Research;Research Personnel;Research Support;Resources;Risk Reduction;risk stratification;Rupture;Secondary to;Sensitivity and Specificity;skill acquisition;skills;standard of care;statistics;Stenosis;Stroke;Stroke prevention;stroke risk;Symptoms;Techniques;Testing;Text;Therapeutic Embolization;Therapeutic Intervention;tool;trait;Transient Ischemic Attack;ultrasound;United Kingdom;United States;vascular bed;Veterans;Work;X-Ray Computed Tomography

PROJECT_TITLE: Genetics of carotid artery disease progression among patients who have failed non-operative management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Conditions Affecting the Embryonic and Fetal Periods;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The proposed project will expand our understanding of the impacts of prenatal cannabis exposure during infancy, childhood, and adolescence. The ensuing studies will help inform early identification of individuals impacted by cannabis exposure during pregnancy as well as guidelines and interventions for mothers and their children.

PI_NAMEs: IKEDA, AMI SALA (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: 2 year old;9 year old;addiction;Address;Adolescence;Adolescent;adolescent substance use;Adult;Age;Age Years;alcohol research;alcohol use disorder;alcohol use initiation;Alcohols;Animals;Area;Behavior;behavioral disinhibition;Behavioral Genetics;Brain;brain tissue;Cannabis;Characteristics;Child;Childhood;Clinical Markers;cognitive development;cognitive function;computing resources;critical period;Data;data reduction;data resource;Data Set;Development;Developmental Delay Disorders;Disease;Disinhibition;Early identification;Endocannabinoids;endogenous cannabinoid system;Etiology;Evaluation;executive function;Exposure to;Failure;fetal;Fetal Alcohol Spectrum Disorder;fetal marijuana exposure;Funding;Goals;Guidelines;high risk;Impulsivity;Income;Individual;infancy;Intervention;Laboratories;Life;Link;Literature;marijuana use;Measures;Mediating;Mediator;Mentors;Modeling;Mothers;Motor;neurobehavioral;neurodevelopment;offspring;Outcome;Pathway interactions;Phenotype;Play;polysubstance use;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Principal Investigator;Race;receptor;Recording of previous events;Recreation;Reporting;response;Risk;Role;sex;Site;substance misuse;substance use;synaptogenesis;Testing;Tobacco;underage drinking;United States;Universities;Visual

PROJECT_TITLE: Prenatal Cannabis: Effects on Developmental Milestones, Disinhibition, and Substance Initiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Defensins are innate immune peptides that provide first-line defense against incoming infections. However, some pathogens, including non-enveloped viruses, have evolved methods to hijack defensins to promote their infectivity. By determining the molecular, cellular, and evolutionary mechanisms of non-enveloped viral defensin escape, we will provide insight into what drives the host/pathogen arms race between innate immune peptides and human viral pathogens and identify new strategies for antiviral development.

PI_NAMEs: HULCE, KAITLIN ROSE (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Adenoviruses;Alanine;alpha-Defensins;antimicrobial;antiviral drug development;arms race;Bacteria;beta pleated sheet;Binding;Biochemical;Biodiversity;Biological Assay;Biophysics;Bypass;Capsid;career development;Cell Culture Techniques;Cells;Cellular Assay;Cellular biology;Charge;collaborative environment;Communication;Core Facility;Defensins;design;Development Plans;dimer;disulfide bond;Education;Elements;Enteral;Enterovirus;Enterovirus 68;Enterovirus 71;Equipment;equity, diversity, and inclusion;Evolution;Exhibits;Exposure to;Faculty;Family;Family Picornaviridae;fungus;High Pressure Liquid Chromatography;HIV-1;Human;Human body;human neutrophil peptide 1;Human Papillomavirus;Immune;Infection;Infectious Diseases Research;Innate Immune System;insight;Libraries;Link;Mammals;member;Mentorship;Methods;Microbiology;Microscopy;Molecular;Myelogenous;neutrophil;Oral;Paneth Cells;pathogen;pathogenic virus;Peptide Synthesis;Peptides;Play;pressure;Property;Research Personnel;Resistance;Resources;respiratory;responsible research conduct;Rhesus;Role;Rotavirus;Route;Scanning;screening;Shigella;Site;Small Intestines;Structure;Surface;Techniques;Testing;Time;Training;transmission process;Universities;Viral;viral resistance;viral transmission;virology;Virus;Virus Diseases;Washington;Work

PROJECT_TITLE: Viruses Hijack Innate Immune Peptides to Enhance Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: OD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Cancer;Eye Disease and Disorders of Vision

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The overwhelming biological similarities between pigs and humans, and the recent development of efficient genome editing tools, such as the CRISPR/Cas9 platform, has increased the utility of pigs as translational models for the elucidation of human disease mechanisms and for the development and validation of clinically relevant therapies and medical devices. This application requests partial support for the Swine in Biomedical Research Conference 2024 (8th in the conference series) to be held at the University of Wisconsin Memorial Union, Madison, Wisconsin, June 14–18. The conference aims to engage human medical scientists/clinicians and veterinarian researchers/animal scientists to identify unmet clinical needs and existing gaps in research that require innovative swine models and to foster new interdisciplinary collaborations.

PI_NAMEs: SHANMUGANAYAGAM, DHANANSAYAN  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Acceleration;Address;Aging;Animals;Area;Biological;Biomedical Research;biomedical scientist;Clinical;clinically relevant;Cloning;Collaborations;college;Communities;CRISPR/Cas technology;demographics;Development;Ensure;Environment;equity, diversity, and inclusion;Event;Eye;Family suidae;Fostering;Future;Genetic;genetic information;genome editing;Goals;graduate student;Growth;Head;Human;human disease;improved;Industry;innovation;interdisciplinary collaboration;Interdisciplinary Study;interest;Journals;Location;Maryland;Medical;Medical Device;meetings;Minority;Mission;Modeling;multidisciplinary;National Center for Advancing Translational Sciences;Outcome;Outcome Assessment;Paper;Peer Review;porcine model;Postdoctoral Fellow;programs;Publishing;Reporting;reproductive;Request for Applications;Research;research facility;Research Personnel;Resources;Scientist;Series;Strategic Planning;success;Surveys;symposium;Techniques;Technology;tool;Translating;translational model;Translations;Underrepresented Populations;United States;Universities;Validation;Veterinarians;Wisconsin;Woman;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZOD1 MCST-F (90)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Anxiety disorders affect approximately 4% of the global population, including greater than 25% of adults in the U.S., and are characterized in part by symptoms of elevated physiological arousal and the avoidance of triggering situations to a degree that negatively impacts a person’s quality of life. Arousal levels and avoidance behaviors are both regulated by noradrenergic activity in the locus coeruleus, but it is unclear how this heterogeneous neuronal population coordinates avoidance behaviors in response to different stimuli. The goal of this proposal is to examine how the modulation of noradrenergic locus coeruleus activity by local inhibitory networks controls arousal levels and avoidance behaviors, which will identify potential new avenues for treatment of anxiety and stress disorders.

PI_NAMEs: MARTIN, MADISON MARGARET (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Academic support;Acute;acute stress;Address;Adult;Affect;Affective;Air;Anatomy;Anxiety;Anxiety Disorders;anxiety treatment;anxiety-like behavior;Arousal;Aversive Stimulus;avoidance behavior;Behavior;Behavioral;behavioral response;Biological;Blinking;Brain;Calcium;career;career development;Cell Nucleus;cell type;Cells;Central Nervous System;Communication;Complex;Computational Technique;Consumption;designer receptors exclusively activated by designer drugs;Development;Development Plans;Disease;Educational process of instructing;Exposure to;Fostering;Goals;Image;in vivo;Individual;innovation;insight;interdisciplinary approach;Investigation;Lasers;Learning;Linear Models;Link;locus ceruleus structure;Mediating;Mentors;Mentorship;Methods;Modality;Monitor;National Institute of Mental Health;neural;neural circuit;neuroimaging;Neurons;neuroregulation;Neurosciences;noradrenergic;Norepinephrine;Odors;Output;pain processing;Persons;Phase;Physiological;Play;Pontine structure;Population;Postdoctoral Fellow;Process;Quality of life;Reporting;Research Personnel;Resolution;response;Role;Science;skill acquisition;skills;Source;Statistical Data Interpretation;Stimulus;Strategic Planning;Stress;stress disorder;stress reactivity;stressor;Structure;Sucrose;Symptoms;Synapses;Testing;Training;training opportunity;Training Support;transmission process;treatment of anxiety disorders;two-photon;Use of New Techniques

PROJECT_TITLE: Characterizing the function of locus coeruleus and pericoerulear zone activity during avoidance behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The International Vasculitis Workshop is the premier academic meeting in the field of vasculitis, attracting the world’s leading clinical, translational, and basic science investigators studying this group of rare diseases. We propose through this grant to provide trainees and junior faculty with opportunities to attend and present their research at the 2024 Workshop where they would receive meaningful recognition and feedback, gain awareness of the broader advances in their areas of inquiry, and develop relationships with senior colleagues that lead to meaningful scientific partnerships. We will also provide trainees/junior faculty with an enrichment program to enhance their experiences at the conference.

PI_NAMEs: MERKEL, PETER A (contact)

PROGRAM_OFFICER_NAME: URV, TIINA K

PROJECT_TERMS: Address;Aging;Applications Grants;Area;Award;Awareness;Basic Science;Biological Markers;Biomedical Research;biomedical scientist;career;career development;Clinical;Clinical assessments;Clinical Data;Clinical Management;Clinical Sciences;Clinical Trials;Collaborations;Communities;Complex;cost;Dedications;Development;Discipline;Disease;diversity and inclusion;Doctor of Philosophy;Educational Curriculum;Educational workshop;Ensure;Environment;Event;experience;Faculty;fascinate;Feedback;Fostering;Functional disorder;Funding;Future;Genetic;Genomics;Geographic Locations;Goals;Grant;Growth;Institution;inter-institutional;interest;International;Investments;Knowledge;Life;Medical;medical specialties;meetings;Mentorship;multidisciplinary;novel therapeutics;Organ;Participant;Patients;peer;Persons;Physicians;posters;pressure;Process;programs;Rare Diseases;Research;Research Personnel;Rotation;Running;Science;Scientific Inquiry;Scientist;Site;Social Network;Spain;standard of care;Support Groups;symposium;Translational Research;Transportation;Travel;United States National Institutes of Health;Vasculitis;Work

PROJECT_TITLE: The 21st International Vasculitis Workshop

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CG-2 (02)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project narrative: We propose here to train, facilitate, and sustain current and future public health in western Africa by developing the in-country workforce to independently conduct pan-pathogen surveillance assays and to analyze and share the resulting data by (1) taking advantage of the transition of existing US/Columbia University-based GAPP Workforce Development training program for capture sequencing to the UCRC Mali Team for Western Africa regional network, (2) creating and implementing scientific writing courses at UCRC using both in-person and remote methods to West African partners focusing on using data generated to produce posters, reports, journal articles, and funding proposals, and (3) creating and Implementing the Masters in Science in Molecular Biology program at UCRC/USTTB. The success of this training program will increase the ability of Mali and other Western Africa countries to become more efficient and independent in their medical surveillance programs. It will also increase the capabilities of our young scientists to step into the global research community.

PI_NAMEs: DOUMBIA, SEYDOU ;WICKISER, JOHN KENNETH (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: academic program;Africa;African;Clinical Research;cohort;Collaborations;Communicable Diseases;Communication;Country;Data;Dedications;Development;Disease Outbreaks;Education;Ensure;experience;fighting;Funding;Genetic;Goals;Health;Healthcare;International;Leadership;Liberia;Mali;Master of Science;Medical;Molecular;Molecular Biology;New York;next generation;Paper;pathogen;Persons;posters;prevent pandemics;Productivity;Program Development;Public Health;Recording of previous events;Regulation;Reporting;retention rate;Scientist;Serology;skills;success;Talents;Training;Universities;Workforce Development;Writing

PROJECT_TITLE: Training West African Public Health and Clinical Research Professionals to Conduct Pan-Pathogen Surveillance Using Sustainable and Effective Genetic, Molecular, and Serological Approaches (TWA-PPPSA)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (55)]