NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative This project investigates the effects of minimum wage increases in the U.S. on maternal health outcomes. It explores potential intermediary pathways through which minimum wage policies may affect maternal health and health care costs associated with pregnancy, as well as disparities in these outcomes. Findings provide causal evidence on the potential for economic policies – such as raising the minimum wage – to address the current maternal health crisis in the U.S.

PI_NAMEs: MCGOVERN, MARK  (contact);ROKICKI, SLAWA

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse outcome;Affect;Age;black women;Canada;Charge;Child;Chronic Disease;Chronic stress;Color;Communities;Complex;Congresses;cost;Data Set;disadvantaged women;Discrimination;Disparity;disparity reduction;economic disparity;economic impact;Economic Policy;Economics;Employment;ethnic minority population;Ethnic Origin;Evaluation;Expenditure;experience;Exposure to;Family;family burden;federal poverty level;Financial Hardship;General Population;Gestational Diabetes;Health;Health behavior;Health Care Costs;health care delivery;health care service utilization;health disparity;Health Expenditures;health inequalities;health outcome disparity;Health Services Accessibility;Health Status;Healthcare;Heterogeneity;Hour;Household;improved;Income;Income Distributions;Infant;Intervention;Lead;lifetime risk;Lifting;Link;Literature;Low income;Marketing;Maternal Health;maternal morbidity;Maternal Mortality;member;Mental Depression;Mental Health Services;Methodology;Minority Women;Mothers;multidisciplinary;Netherlands;Not Hispanic or Latino;Obesity;Outcome;Pathway interactions;people of color;peripartum depression;Persons;Play;Policies;poor health outcome;Population;post pregnancy;postpartum care;Poverty;poverty reduction;Pre-Eclampsia;Pregnancy;pregnancy health;Pregnant Women;Prenatal care;prepregnancy;Preventive healthcare;Public Health;Quasi-experiment;Race;racial disparity;racial minority population;reproductive;Reproductive Health;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Role;Running;severe maternal morbidity;Smoke;Smoking;social determinants;social health determinants;societal costs;Societies;Source;structural determinants;Structural Racism;tool;Translating;Uninsured;Uninsured Medical Expense;United States;Wages;White Women;Woman;women's reproductive health

PROJECT_TITLE: Minimum wages and maternal health in the U.S.

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DURHAM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Relevance V(D)J recombination is essential for the development of a functional adaptive immune system. Failure of V(D)J recombination can cause immunodeficiency and dysregulated V(D)J recombination can result in autoimmunity or chromosomal translocations that contribute to tumorigenesis. These studies will elucidate basic mechanisms that contribute to normal immune system development as well as pathologies such as immunodeficiency, autoimmunity and cancer.

PI_NAMEs: KRANGEL, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Alleles;Antigen Receptors;Antigens;Autoimmunity;B-Lymphocytes;Characteristics;Chromatin;Chromatin Structure;Chromosomal translocation;combinatorial;Complex;Development;DNA;DNA Damage;Ensure;Event;Exclusion;Failure;Generations;Genes;genetic manipulation;Genetic Recombination;Genetic Transcription;genome integrity;genomic locus;Immune system;immunodeficiency;in vivo;insight;Instruction;Jaw;Knowledge;Lymphocyte;Lymphocyte Subset;Malignant Neoplasms;Maps;Modification;Molecular;Molecular Conformation;Mus;novel;Nuclear Lamina;Outcome;Pathology;Play;Production;programs;receptor;Receptor Gene;recombinase;Regulation;response;Role;Specificity;success;Systems Development;T cell regulation;T-Cell Development;T-Cell Receptor;T-Lymphocyte Subsets;thymocyte;Thymocyte Selection;tumorigenesis;V(D)J Recombination;Vertebrates;Work

PROJECT_TITLE: Chromatin regulation of TCR locus V(D)J recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE Despite significant advances in the development of nanobiomaterials for controlled drug delivery, substantial difficulties remain for the scalable nanofabrication and encapsulation of therapeutics. In particular, the encapsulation and intracellular delivery of water-soluble payloads, like proteins and nucleic acids, still present difficulties for reproducibility, especially when co-loading multiple drugs that each possess distinct physicochemical properties. To address these issues, we will model, optimize and validate a novel scalable means of supramolecular homopolymer self-assembly that achieves >90% encapsulation efficiency universally for multiple hydrophilic and hydrophobic small molecules and biologics simultaneously.

PI_NAMEs: SCOTT, EVAN ALEXANDER (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Adjuvant;amphiphilicity;Antigens;aqueous;Area;Bacteria;Biochemical;Biocompatible Materials;Biodistribution;Biological Assay;Biological Products;biomaterial compatibility;Biomimetics;Chemicals;Chemistry;chemotherapy;Circular Dichroism;clinical translation;Complex;Contrast Media;copolymer;Data Reporting;Development;Dimethyl Sulfoxide;DNA;Drug Delivery Systems;Drug Formulations;Employment;Encapsulated;Environment;Equilibrium;experience;experimental study;fabrication;Flow Cytometry;fluorophore;Gel;Grain;Histology;Hydration status;Hydrogels;hydrophilicity;Hydrophobicity;immunogenicity;Immunotherapy;In Vitro;in vivo;Individual;Inflammation;innovation;insight;Leucine Zippers;Maps;Methodology;Methods;Microscopy;Modeling;Molecular;molecular dynamics;Morphology;Mus;nanobiomaterial;nanofabrication;NanoGel;nanoscale;Nanostructures;Nature;novel;Nucleic Acids;Organ;Peptide Hydrolases;Pharmaceutical Preparations;Population Heterogeneity;Process;Property;propylene;Proteins;Proteomics;Publishing;Recording of previous events;Reporting;Reproducibility;research clinical testing;RNA;scale up;self assembly;Series;simulation;small molecule;Solvents;Spatial Distribution;Specific qualifier value;stem;Structure;Sulfones;System;Testing;Therapeutic;tool;Toxic effect;Tracer;vaccine efficacy;vaccine formulation;vaccine immunogenicity;vaccine platform;Vaccines;Vertebral column;Vesicle;Water

PROJECT_TITLE: A universal multi-drug encapsulation and delivery system employing supramolecular nanogels that self-assemble via dynamic sulfone bonding

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Lung;Neurosciences;Pediatric;Precision Medicine;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: MAYWOOD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE The muscarinic acetylcholine receptor 1 (CHRM1, M1) is critical for cholinergic neurotransmission and the subject of multiple drug discovery programs, as well as an ongoing clinical trial for cognition in Alzheimer’s disease. Using 44 temporal cortex samples, we have established that CHRM1 expression is significantly decreased in the brains of defined subpopulations of patients with the neurodevelopmental disorder Rett syndrome (RTT), and that positive allosteric modulation of the M1 receptor improves multiple symptom domains of RTT model mice. Here we propose to 1) test the effects of M1 potentiation against a battery of RTT phenotypes 2) establish a paradigm to use mutation type to drive precision medicine therapeutics in RTT and 3) define the mechanism of action of M1 PAMs on RTT respiratory phenotypes.

PI_NAMEs: GOGLIOTTI, ROCCO GEORGE (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;Agonist;Alleles;Alzheimer's Disease;Amygdaloid structure;Apnea;Autopsy;Brain;Brain Stem;Cell Nucleus;cell type;Cerebellar Cortex;Cessation of life;Chemosensitization;cholinergic;CHRM1 gene;CHRM4 gene;Chronic;Clinical;Clinical Trials;Cognition;Complement;Coupling;Data;Data Set;debilitating symptom;Desipramine;Development;Dose;drug discovery;druggable target;experimental study;Failure;Female;Frequencies;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic testing;Goals;Human;Hyperventilation;Hypoxia;Impairment;improved;in vivo;individual patient;interest;Intervention;Knock-in Mouse;Knockout Mice;Link;Location;locus ceruleus structure;male;Mediating;Methyl-CpG-Binding Protein 2;Missense Mutation;Modeling;Molecular;mosaic;Motor;Motor Cortex;mouse model;Mus;Muscarinic Acetylcholine Receptor;Mutation;Nature;Neurodevelopmental Disorder;Neurologic Dysfunctions;Neurons;neuropsychiatric disorder;neurotransmission;noradrenergic;Norepinephrine;novel;Outcome;Outcome Measure;Oxidative Stress;Pathogenicity;Pathway interactions;patient subsets;Patients;Pattern;Periodicity;pharmacologic;Pharmacology;Phase II Clinical Trials;Phenotype;Physiological;positive allosteric modulator;pre-clinical;precision medicine;preclinical development;premature;programs;Proteins;Proteomics;Reader;receptor;receptor expression;receptor function;Research;Respiration Disorders;respiratory;response;Rett Syndrome;Risk;Risk Factors;Role;Safety;Sampling;Scanning;Seizures;Seminal;Severities;Severity of illness;Signal Transduction;single nucleus RNA-sequencing;Site;small molecule;social;Symptoms;Synaptic plasticity;Syndrome;Temporal Lobe;Testing;Therapeutic;therapeutic target;timeline;Transcript;transcriptome;transcriptome sequencing;virtual;Whole Body Plethysmography

PROJECT_TITLE: A precision medicine approach to Rett Syndrome

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Human Genome;Microbiome;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Despite remarkable advances in the immunopathogenesis of autoimmune and immune mediated diseases (AIMDs), the environmental factors that orchestrate the initiation and perpetuation of these disorders or determine therapeutic responses remain to be fully elucidated. Chief among them is the human microbiome, which has long been shown to contribute to inflammatory diseases. Successful completion of our proposed studies will provide key insights into the pathogenesis of AIMDs by interrogating (a) if the gut, skin and oral microbiome contribute to the initial inflammatory events in AIMDs, and (b) whether the gut microbiome can serve as a modulator of therapeutic responses to currently available drugs, ultimately identifying patients that are more likely to experience clinical improvement prior to treatment initiation.

PI_NAMEs: CLEMENTE, JOSE C;HEGUY, ADRIANA ;SCHER, JOSE U. (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;Affect;Atopic Dermatitis;Autoimmune;autoimmune pathogenesis;Biological Assay;Biological Markers;Biological Response Modifier Therapy;Biopsy;Cell Communication;Cells;Clinical;clinical phenotype;cohort;Collaborations;Communities;Computer software;Cues;Custom;Data;Democracy;Dermatology;Development;Disease;disease heterogeneity;Disease Pathway;drug metabolism;drug response prediction;Drug toxicity;dysbiosis;early onset;Environmental Risk Factor;Event;experience;field study;Gene Expression Profiling;Genes;Genetic;Goals;Growth;gut microbiome;Heterogeneity;high dimensionality;High-Throughput Nucleotide Sequencing;Human;Human Microbiome;Immune;immune activation;immune modulating agents;Immunoglobulin A;improved;Individual Differences;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;interest;Intervention;Investigation;Knowledge Portal;Link;Lupus;Malignant Neoplasms;Mediating;medical schools;Metadata;metagenome;Metagenomics;metatranscriptomics;Methods;Methotrexate;Microbe;microbial;microbial composition;microbial disease;microbiome;microbiome analysis;microbiome research;microbiome therapeutics;microbiota;microorganism;Molecular;multidisciplinary;Mus;new technology;novel;Onset of illness;Oral cavity;oral microbiome;Oral mucous membrane structure;oral tissue;Outcome;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;precision medicine;Prediction of Response to Therapy;predictive modeling;predictive tools;programs;Psoriasis;Psoriatic Arthritis;Publications;Quality of life;reconstruction;Research Personnel;Resolution;Resources;responders and non-responders;response;Rheumatoid Arthritis;rheumatologist;Rheumatology;Ribosomal RNA;Role;Salivary Glands;Sampling;Shotguns;single-cell RNA sequencing;Site;Sjogren's Syndrome;Skin;skin microbiome;Skin Tissue;Surface;Systemic Lupus Erythematosus;Systems Biology;Technology;Therapeutic;Tissue Banks;Tissues;transcriptome;transcriptomics;treatment response;Variant;Work

PROJECT_TITLE: Micro-TeACH (Microbiome Technology and Analytic Center Hub)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE African Americans experience the highest levels of tobacco-related disease and death, despite smoking fewer cigarettes per day than Whites, and have relatively low quit rates when stopping smoking. Finding new approaches to enhancing treatment for African American smokers is a critical public health priority, and identifying methods of improving treatment outcomes from existing pharmacotherapy is central to this goal. This study will evaluate the efficacy of extended varenicline treatment to improve quit rates in African American daily smokers of all smoking levels, with the goal of reducing tobacco-related health disparities, and thereby reducing morbidity and mortality in this high-risk group.

PI_NAMEs: COX, LISA SANDERSON (contact)

PROGRAM_OFFICER_NAME: CICCOLO, JOSEPH THOMAS

PROJECT_TERMS: Abstinence;Adherence;African American;African American population;Age;arm;biobehavior;Biological Factors;Blood;Cessation of life;Cigarette;clinical practice;Clinical Trials;clinically relevant;Communities;Cotinine;Counseling;Country;craving;design;Disease;Disparity;effective therapy;efficacy evaluation;Evaluation;experience;FDA approved;Gender;Goals;Health;health disparity;high risk population;improved;Incidence;Individual;Light;long term abstinence;Longterm Follow-up;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Mediation;Mediator;medication compliance;Menthol;Metabolism;Methods;Morbidity - disease rate;mortality;multidisciplinary;negative affect;Nicotine;nicotine exposure;novel strategies;Outcome;Participant;Pattern;Pharmaceutical Preparations;Pharmacotherapy;pill;Predictive Factor;Premature Mortality;Prevalence;Psychological reinforcement;public health priorities;Randomized;Recovery;Relapse;relapse prevention;Relative Risks;response;Safety;Smoke;Smoker;Smoking;smoking abstinence;Smoking Behavior;smoking cessation;smoking prevalence;Socioeconomic Status;standard care;success;Time;Tobacco;tobacco abstinence;Tobacco smoking behavior;Tobacco use;treatment adherence;treatment comparison;treatment effect;Treatment Efficacy;treatment group;Treatment outcome;treatment response;United States;varenicline;Variant;Visit;Withdrawal;Work

PROJECT_TITLE: Improving smoking abstinence outcomes in the African American community through extended treatment

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Diabetes;Kidney Disease;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Diabetes is a disorder of high blood glucose, that tends to get worse; over time, patients need more and more drugs. This pattern is caused by overwork of the body's insulin-producing β-cells, because patients' glucose levels are typically above normal; if we kept glucose levels normal – reducing β-cell work – we might be able to keep the disease from getting worse. Our trial is aimed to show that adjusting the drugs to keep glucose levels normal, can help to preserve β-cell function compared to usual diabetes care, possibly reduce the tendency to develop the eye and kidney complications of diabetes, and might also be more cost-effective than usual care.

PI_NAMEs: PHILLIPS, LAWRENCE S (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Acceleration;Adherence;Adult;Apoptosis;Beta Cell;Blinded;Blood Glucose;Blood Glucose Self-Monitoring;Body Weight decreased;Caring;cell dedifferentiation;Cell Physiology;Clinical;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Control Groups;cost;cost effective;cost effectiveness;Diabetes Mellitus;diabetes prevention program;Disease;Disease remission;dosage;Dropout;Early Diagnosis;Ensure;Evaluation;excitotoxicity;Eye;FDA approved;Fundus;glargine;glucagon-like peptide 1;Glucose;Glycosylated hemoglobin A;Goals;Hour;Hyperglycemia;Hypoglycemia;improved;Insulin;Intervention;Intervention Studies;Kidney;Kidney Diseases;Life Style;lifestyle intervention;Maintenance;Mediating;Medical;Metformin;Methods;Microalbuminuria;Modeling;mortality;Natural History;Non-Insulin-Dependent Diabetes Mellitus;novel;OGTT;Outcome;Outcome Study;Patients;Pattern;Pharmaceutical Preparations;Pioglitazone;Prediabetes syndrome;preservation;prevent;Prevention;Primary Care;progression risk;Randomized;Retinal Diseases;Risk;Running;Testing;Time;Translating;treatment arm;treatment as usual;trend;Work

PROJECT_TITLE: CHANGING THE NATURAL HISTORY OF TYPE 2 DIABETES – “CHANGE” STUDY

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative  We propose to test Black Girls Move, a school-linked daughter/mother physical activity and dietary behavior program, with 9th and 10th grade students. This program is designed to prevent obesity in Black adolescent females and thus aligns with the NIH mission to enhance health, lengthen life, and reduce illness and disability. This project is relevant to public health because it holds the potential to reduce population health disparities impacted by structural racism.

PI_NAMEs: REED, MONIQUE A (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Address;Adolescence;Adolescent;Adopted;Adoption;Adult;Affect;aged;anti-racism;Area;Behavior;Black race;black women;Body mass index;Buffers;burden of illness;Cardiovascular system;Chicago;Child;Clinical Trials;Clinical Trials Design;Collaborations;comorbidity;comparative efficacy;Complex;Consumption;coping mechanism;Dairying;Data;Daughter;design;Development;Diet;dietary;Dietary Fiber;Dietary intake;disability;Disease;Disparity;disparity reduction;Educational process of instructing;efficacy trial;Environment;experience;Exposure to;Family;Female;Female Adolescents;Fruit;Future;Gender;girls;Goals;Group Meetings;Health;Health behavior;health disparity;health disparity populations;Health Food;Healthy Eating;healthy lifestyle;high school;improved;indexing;innovation;Intake;intersectionality;Intervention;Learning;Life;Life Style;Link;Literature;Measures;Metabolic;Methods;Mission;modifiable risk;Monitor;Morbid Obesity;Morbidity - disease rate;mortality;Mothers;National Institute of Diabetes and Digestive and Kidney Diseases;ninth grade;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Obesity;obesity management;obesity prevention;obesity risk;obesity treatment;obesogenic;Outcome;outcome disparities;Participant;Patient Self-Report;perceived discrimination;Phase;Physical activity;Pilot Projects;pilot trial;Play;Positioning Attribute;post intervention;Prevalence;prevent;Prevention;preventive intervention;primary outcome;Process;programs;Proteins;Public Health;Race;racial discrimination;racial identity;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reporting;Research;residential segregation;response;Risk Factors;Role;Sampling;satisfaction;Schools;secondary outcome;Self Assessment;Shapes;social cognition;social cognitive theory;Strenuous Exercise;Structural Racism;Students;sugar;sweetened beverage;Systems Theory;tenth grade;Testing;United States National Institutes of Health;Vegetables;walkability;White Women

PROJECT_TITLE: Black Girls Move: A Daughter/Mother Intervention to Prevent Obesity by Increasing Physical Activity and Improving Dietary Intake among Black Adolescent Daughters

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Aging;Cancer;Complementary and Integrative Health;Diabetes;Dietary Supplements;Natural Products;Nutrition;Obesity;Osteoporosis;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CHARLES R. DREW UNIVERSITY OF MED & SCI

ORG_STATE: CA

PHR: Project Narrative The proposed project is anticipated to advance our understanding of certain critical molecular events involved in disease pathogenesis, thereby enhancing the development of optimal strategies in disease prevention and treatment. This project will also characterize a novel promising natural compound, which has shown potential benefits against several disorders and diseases such as inflammation, cardiovascular diseases, neurological diseases, obesity, diabetes, and cancer.

PI_NAMEs: WANG, PIWEN  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Adipocytes;Anti-Inflammatory Agents;Antioxidants;arctigenin;Area;Atherosclerosis;Binding;Biological Availability;cancer cell;cancer type;Cardiovascular Diseases;CCL2 gene;cell motility;Cells;chemokine;chemokine receptor;Chronic Disease;Clinical Trials;Compensation;cytokine;Development;Diabetes Mellitus;Disease;disease model;disorder control;disorder prevention;Dose;Drug Kinetics;Endothelial Cells;Enzymes;Event;Family;Fibroblasts;G-Protein-Coupled Receptors;Goals;Greater Burdock;Herb;Human;Immune;improved;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;interest;Knowledge;Laboratories;Leukocytes;Ligands;Lignans;loss of function;Malignant Neoplasms;Mediator;Molecular;Molecular Target;monocyte chemoattractant protein 1 receptor;Natural Compound;Natural product discovery;neoplastic cell;Nervous System Disorder;novel;Obesity;Osteoporosis;Pathogenesis;Patients;Pharmaceutical Preparations;Phytochemical;pre-clinical;Prevention;Preventive;programs;prostate cancer model;Quality of life;Reaction;recruit;Research;Signal Pathway;Signal Transduction;Source;Therapeutic Agents;Viral;Vision

PROJECT_TITLE: Signaling mediators of CCL2/CCR2 and natural product discovery


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ELKINS PARK

ORG_NAME: SALUS UNIVERSITY

ORG_STATE: PA

PHR: PUBLIC HEALTH RELEVANCE Mutations in genes GUCY2D and GUCA1A cause retinal degeneration by deregulating cGMP production in photoreceptors. We propose to explore versatile molecular mechanisms capable of averting the adverse biochemical process causing death of photoreceptors and thus rescue them. This knowledge can become useful in developing treatment for the presently incurable GUCY2D and GUCA1A dominant retinopathies.

PI_NAMEs: DIZHOOR, ALEXANDER M (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acceleration;Address;Alleles;Animal Model;autosomal dominant mutation;Binding;Biochemical;Biochemical Pathway;Biochemical Process;Blindness;Cause of Death;Cessation of life;cGMP production;Code;Complex;cone-rod dystrophy;Cyclic GMP;Darkness;design;Development;Disease;Ectopic Expression;Engineering;Eye diseases;Foundations;Future;gain of function;gain of function mutation;gene therapy;Genes;Genetic Models;guanylate;Guanylate Cyclase;guanylate cyclase activating protein;Human;Hydrolysis;inhibitor;Isoenzymes;Knowledge;Light;Link;Mission;Molecular;mouse development;mouse model;Mus;mutant;Mutation;novel strategies;overexpression;phosphodiesterase V;phosphoric diester hydrolase;photoreceptor degeneration;Photoreceptors;Phototransduction;Physiological;Physiology;Point Mutation;preservation;prevent;Production;prospective;Protein Engineering;protein expression;Protein Isoforms;Proteins;public health relevance;Recombinants;Reporting;Research;Research Support;Retina;Retinal Degeneration;Retinal Diseases;RNA Interference;Rod;Rod Outer Segments;stem;Study models;targeted treatment;Testing;tool;transgene expression;Transgenic Animals;Transgenic Mice;Transgenic Model;Variant;Vertebrate Photoreceptors;Vision;Vision Disorders

PROJECT_TITLE: Mechanisms to Rescue Photoreceptors in GUCY2D and GUCA1A Retinopathies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE We propose to continue an impactful biomedical research center to foster investigations applying cutting-edge innovations to illuminate the causes of human disease occurrence and progression. As such, our Center has the potential to change policy and practice and to reduce disease burden throughout the life course. Our COBRE Center for Molecular Epidemiology provides a unique and critical resource from which to grow the next generation of scientists as well as advance more senior investigators within Dartmouth, with regional partners, and across molecular epidemiology more broadly.

PI_NAMEs: KARAGAS, MARGARET RITA (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Achievement;Address;Award;biobank;Biomedical Research;biomedical scientist;burden of illness;career;career development;Centers of Research Excellence;clinical practice;Collaborations;college;Communities;Consensus;Core Facility;Department chair;Disease;Disease Pathway;Early identification;Early Intervention;empowerment;Endowment;Ensure;Epidemiologist;Epidemiology;Etiology;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;forging;Fostering;Funding;Future;Grant;Health;health equity promotion;health inequalities;Health Personnel;Household;Human;human disease;indexing;Influentials;Infrastructure;innovation;Institution;interest;International;Investigation;Investments;Joints;Leadership;Life Cycle Stages;medical schools;member;Mentors;Mentorship;Methods;Molecular;molecular dynamics;Molecular Epidemiology;multidisciplinary;New England;next generation;Pathogenesis;Pediatric cohort;Peer Review;Phase;Pilot Projects;Policies;Population;Positioning Attribute;prevent;Prevention strategy;Principal Investigator;Productivity;programs;Public Health;Publications;recruit;Research;research and development;Research Infrastructure;Research Personnel;Resources;Schools;Science;Scientific Advances and Accomplishments;Scientist;Services;Strategic Planning;Strategic vision;Structure;success;Talents;Technology;tool;Training;Trustees;United States National Institutes of Health

PROJECT_TITLE: Center for Molecular Epidemiology


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PROJECT_TERMS: Acceleration;Achievement;Address;Adherence;Adoption;Advisory Committees;biobank;biomedical scientist;Cancer Center;career development;Centers of Research Excellence;Collaborations;commercialization;Communication;Communities;community advisory board;Decision Making;design;Disease;Disease Pathway;driving force;Early identification;Educational workshop;Ensure;Epidemiologist;equity, diversity, and inclusion;Etiology;Evaluation;Fostering;Funding;Future;Generations;Goals;Health;health care delivery;health inequalities;Health system;Human;human disease;Human Resources;human subject protection;improved;Infrastructure;Institution;International;Leadership;Measures;medical schools;member;Mentors;Mission;Molecular;Molecular Epidemiology;Monitor;operation;Pathogenesis;Performance;Pilot Projects;Policies;Procedures;Productivity;programs;Recommendation;recruit;Reporting;Research;research and development;Research Personnel;Research Priority;Resource Development;resource guides;Resource Sharing;Resources;Safety;Scientist;Services;Strategic Planning;Structure;symposium;synergism;Talents;Technology;Training;Translations;United States National Institutes of Health;Work

PROJECT_TITLE: Core A: Administrative, Career Development, and Research  Integration Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Project Narrative The vital single-cell lining (epithelium) of digestive organs is sustained by cells that lie beneath it (mesenchyme) and provide known and unknown signals. This proposal aims to provide new insights into the mesenchymal compartment’s role during fetal development and restoration of intestinal stem cells after lethal cell injury. The studies will improve understanding of how interactions between the epithelium and mesenchyme may be harnessed in the future to develop new treatment approaches toward inflammatory bowel disorders and cancers.

PI_NAMEs: MCCARTHY, NEIL  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Address;Adult;Agonist;Anatomy;antagonist;base;Biological Assay;Biology;Birth;Bone Morphogenetic Proteins;Cancer Etiology;CD81 gene;cell injury;Cell Line;Cell Separation;cell type;Cells;Cessation of life;Coculture Techniques;Colorectal Cancer;Constitution;crypt cell;Data;Development;Disease;Elements;Embryo;Environment;epithelial repair;Epithelium;Equilibrium;Exhibits;experimental study;fetal;Fetal Development;Fingers;Future;Gene Expression Profile;Genetic;Growth;Growth Factor;Homeostasis;improved;In Vitro;in vivo;Inflammatory Bowel Diseases;Injury;insight;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Knock-out;Ligands;Malignant Neoplasms;Mesenchymal;Mesenchyme;Methods;Microscopy;Molecular;Molecular Profiling;Mus;Natural regeneration;novel;novel therapeutic intervention;Organ;Organoids;Pathway interactions;PDGFRA gene;Population;Process;progenitor;Proliferating;protein function;Protein Inhibition;Reaction;Recombinants;regenerative;Regenerative response;Regulation;Resolution;response;Rest;restoration;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Small Intestines;Stem Cell Development;stem cell homeostasis;stem cell niche;stem cell proliferation;stem cell self renewal;stem cells;Structure;Testing;Tissues;transcriptome sequencing;Tube;United States;Villous;Villus

PROJECT_TITLE: Mesenchymal regulation of fetal intestinal development and adult regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: NEUROLOGY

PHR: Project Narrative It is well established that fasting glucose levels increase with aging, and that impaired glucose metabolism is a risk factor for Alzheimer’s Disease. Heat therapy has been independently shown to improve blood glucose regulation, insulin resistance, and inflammation. This project will provide a comprehensive understanding of the impact of heat therapy on glucose homeostasis and brain health.

PI_NAMEs: GEIGER, PAIGE C;MORRIS, JILL KATHLEEN (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Bioenergetics;Biological Markers;Blood;Blood Glucose;blood glucose regulation;Blood Pressure;Blood Vessels;Body mass index;Brain;brain health;Centers for Disease Control and Prevention (U.S.);Cerebrovascular Circulation;Cerebrum;Clinical;Clinical Trials;Cognitive;Continuous Glucose Monitor;Diabetes Mellitus;Diagnosis;Disease;Elderly;Endocytic Vesicle;Energy Metabolism;Etiology;experience;fasting glucose;Fibromyalgia;fluorodeoxyglucose;Glucose;glucose metabolism;glycemic control;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Heat shock proteins;Human;human old age (65+);Impairment;improved;indexing;Individual;Inflammation;Insulin Resistance;insulin sensitivity;Interleukin-10;Interleukin-6;Intervention;Link;Liquid substance;Magnetic Resonance Imaging;Maintenance;Measures;Metabolic;Metabolism;Mitochondria;Molecular Chaperones;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging marker;neuropathology;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;older adult;Organ;Outcome;Outcome Measure;Oxygen;Plasma;Populations at Risk;Positioning Attribute;post intervention;Prediabetes syndrome;prevent;primary outcome;proteostasis;Quality Control;response;Rest;Risk;Risk Marker;Senile Plaques;Standardization;System;tau Proteins;Testing;Therapeutic heat application;Time;Tissues;TNF gene;Translating;uptake;vascular risk factor

PROJECT_TITLE: Feasibility of Improving Glycemia to Prevent Alzheimer's Disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics

PI_NAMEs: CHRISTENSEN, BROCK CLARKE (contact)

PROJECT_TERMS: Administrative Supplement;Aliquot;Archives;base;biobank;Biocompatible Materials;Bioinformatics;Biological;Biological Assay;Businesses;Centers of Research Excellence;Chemicals;Clinical Laboratory Information Systems;Code;Collaborations;Collection;commercialization;Communities;Complex;Consultations;Core Facility;Data;design;Disease;DNA;Educational Materials;epidemiology study;Equipment;experience;Fees;flexibility;Funding;Future;genome-wide analysis;Human;human disease;improved;Information Management;Information Systems;Infrastructure;Institution;International;investigator training;Investments;Laboratories;Link;Marketing;Masks;Measures;member;metabolomics;Metagenomics;Mission;Modernization;Molecular;Molecular Epidemiology;Monitor;multidisciplinary;novel;Participant;Performance;Phase;Pilot Projects;Procedures;Process;programs;protocol development;Protocols documentation;Quality Control;Randomized;Research;Research Design;Research Personnel;Resources;Robotics;Sampling;Schools;Secure;Security;Services;single cell genomics;Site;Specimen;Strategic Planning;System;Technology;Training;Translational Research;Triage;United States National Institutes of Health;Update

PROJECT_TITLE: Core B: Biorepository and Biospecimen Resource Facility Core


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MINEOLA

ORG_NAME: NEW YORK UNIVERSITY D/B/A NYU LONG ISLAND SCHOOL OF MEDICINE

PHR: NARRATIVE – OVERALL: ApoB-containing atherogenic lipoproteins are the primary cause of atherosclerotic cardiovascular disease. We propose to understand the roles of liver, adipose tissue, and vascular endothelail cells in producing these atherogenic lipoproteins, a coordinated effort that will uncover novel targets, treatments, pathways, and mechanisms useful for future personalized therapies to reduce the risk of atherosclerosis.

PI_NAMEs: HUSSAIN, M MAHMOOD (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Adipocytes;Adipose tissue;Affect;Anabolism;Animals;Apolipoproteins B;Applications Grants;Arteries;atherogenesis;Atherosclerosis;atherosclerosis risk;Biogenesis;Bioinformatics;Biological Assay;Biology;Biometry;Blood;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Catabolism;Cause of Death;Cells;Cholesterol;Chylomicrons;Circulation;clinical application;Collaborations;Communication;Country;Data;data management;Development;dietary;Dietary Fats;Disease;Dissection;DNA Sequence Alteration;Endothelial Cells;Ensure;Evaluation;Event;experimental study;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;Future;Goals;Hepatic;Hepatocyte;Human;human data;Human Genetics;human tissue;Hypertriglyceridemia;Infiltration;Inflammation;innovation;insight;Intervention;Intestines;Intracellular Transport;Knockout Mice;Knowledge acquisition;Link;lipid metabolism;lipidomics;Lipids;Lipolysis;Lipoprotein (a);Lipoproteins;Liver;Low-Density Lipoproteins;Metabolism;modifiable risk;Morality;Morbidity - disease rate;mouse model;Mus;N-terminal;new therapeutic target;non-alcoholic fatty liver disease;novel;novel strategies;Outcome;Pathway interactions;Peripheral;personalized medicine;Persons;Pharmaceutical Preparations;prevent;Process;Production;Program Research Project Grants;programs;Proteins;Proteomics;receptor;Research Personnel;Residual state;Resistance;Resources;Risk;Risk Factors;Risk Reduction;Rodent Model;Role;Route;Sampling;synergism;therapeutic target;Tissues;tool;transcriptomics;transcytosis;Translating;Triglyceride Metabolism;Triglycerides;Underrepresented Minority;United States National Institutes of Health;uptake;Vascular Endothelial Cell;Very low density lipoprotein;Weight;Work

PROJECT_TITLE: Biogenesis and Catabolism of Atherogenic Lipoproteins

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Protein homeostasis is a central aspect of cellular regulation. Defects in pathways that mediate protein stability and degradation including the ubiquitin proteasome pathway contribute to many disease processes including cancers. This study will advance our understanding of the protein homeostasis in cell function.

PI_NAMEs: ESTELLE, MARK A (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Angiosperms;Arabidopsis;Architecture;Auxins;cell growth regulation;Cell Physiology;ChIP-seq;Chromatin;Collaborations;Complex;Defect;derepression;Developmental Process;Disease;Droughts;Exclusion;experimental study;F Box Domain;Family;gene regulatory network;Genes;Genetic;Genetic Transcription;Glucosinolates;Goals;Grant;Growth;Health;Human;interest;Investigation;Malignant Neoplasms;Mediating;member;Molecular;Mouse-ear Cress;multicatalytic endopeptidase complex;novel;Orthologous Gene;Pathway interactions;Physcomitrella;Physiological Processes;Plant Growth Regulators;plant growth/development;Plants;Process;Proteins;proteostasis;receptor;recruit;Regulation;response;Role;Signal Transduction;Specificity;System;transcription factor;Transcription Repressor;Ubiquitin;ubiquitin-protein ligase;virtual

PROJECT_TITLE: Novel auxin signaling components and pathways.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


PROJECT_TERMS: Adherence;Administrative Efficiency;animal care;Animals;Atherosclerosis;Authorization documentation;Award;Biogenesis;cardiovascular disorder risk;Catabolism;Charge;Conflict of Interest;Consultations;Contract Services;Ensure;Environment;Environmental Health;Equipment;follow-up;Funding;Goals;Guidelines;Human Resources;Immigration;innovation;Institution;invention;Lead;Lipoproteins;meetings;Metabolism;National Heart, Lung, and Blood Institute;next generation;novel therapeutics;operation;Persons;Preparation;Productivity;programs;Progress Reports;Protocols documentation;Publications;Regulation;repaired;Report (document);Reporting;Research;Research Personnel;Risk Reduction;Scientist;synergism;Time;Training;United States National Institutes of Health;Update;webinar

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative  Traumatic brain injury and comorbid alcohol use disorder cause heavy medical, economic, and social issues. This project aims to identify a novel N-acetyl-serotonin therapy for traumatic brain injury-induced alcohol consumption and advance the understanding of the protective mechanisms by which N-acetyl-serotonin targets the BDNF/TrkB/Akt pathway and inflammation.

PI_NAMEs: WANG, XIN  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Address;Adult;Affinity;Agonist;alcohol comorbidity;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcohol-Induced Disorders;Alcohol-Induced Neurotoxicity;Alcohols;American;Animal Model;Animals;anti-depressive agents;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Apoptotic;Astrocytes;Biological Assay;Brain;Brain-Derived Neurotrophic Factor;cell injury;Cell model;Cells;Cerebellum;Cerebral Ischemia;Circadian Rhythms;Clinical;Cognitive;Cognitive deficits;Corpus striatum structure;Cultured Cells;Data;Diagnosis;disability;drug development;drug discovery;Economics;Enzyme-Linked Immunosorbent Assay;Ethanol;experience;fluoro jade;Functional disorder;Glial Fibrillary Acidic Protein;Goals;Hepatocyte;Hippocampus;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Inflammation;Injury;Interleukin-1 beta;Interleukin-6;Intervention;Knockout Mice;liver ischemia;Mediating;Medical;Modeling;Molecular;multidisciplinary;Mus;Nerve Degeneration;neurobehavioral;Neurons;Neuroprotective Agents;neurotoxicity;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Performance;Pharmaceutical Preparations;Play;Post-Traumatic Stress Disorders;preference;prevent;protective effect;Publications;receptor;Receptor Protein-Tyrosine Kinases;Recording of previous events;Recovery;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;retinal ischemia;Risk Factors;Role;Serum;Silver Staining;social;Solid;success;TBI Patients;TBI treatment;Testing;tissue injury;Traumatic Brain Injury;Veterans;Western Blotting

PROJECT_TITLE: N-acetylserotonin alleviates neurotoxicity in alcohol misuse following TBI

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE HIV is a treatable and preventable disease but there are individuals who have not benefited from therapies to control the virus, improve health, and decrease transmission. We hope to understand why this happens to certain individuals, and develop tools to improve HIV treatment and prevention.

PI_NAMEs: KASSAYE, SEBLE G (contact);MERENSTEIN, DANIEL J

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;aged;Aging;Anti-Retroviral Agents;antiretroviral therapy;Area;Behavioral;Behavioral Research;behavioral study;Biological Factors;Biological Markers;Blood Vessels;Capital;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care providers;Categories;Chronic;cohort;Cohort Studies;Collaborations;community-level factor;comorbidity;Complex;Continuity of Patient Care;coping;data acquisition;Death Rate;Diagnosis;Disease;Disease Outcome;Disparity;disparity reduction;District of Columbia;Dyslipidemias;effective therapy;effectiveness evaluation;Enrollment;Ensure;Epidemic;equilibration disorder;Failure;Funding;Geographic Factor;Geography;glucose metabolism;Goals;Health;health seeking behavior;Healthcare Systems;healthy aging;Hearing problem;high risk;HIV;HIV Infections;HIV Seropositivity;immune activation;Immunologics;Impairment;improved;Individual;innovation;Intervention;Knowledge;Lead;Leadership;Life;male;Malignant Neoplasms;Maryland;Measures;Mediating;men;men's group;Mental disorders;Metabolic;metropolitan;microbiome;Morbidity - disease rate;mortality;Neurocognitive Deficit;Newly Diagnosed;novel;optimal treatments;Outcome;Participant;participant enrollment;Persons;Play;Population;Positioning Attribute;pre-clinical;Prevalence;prevent;Prevention;Prevention Guidelines;Preventive screening;Productivity;protocol development;Protocols documentation;psychosocial;racial difference;recruit;Research;Research Personnel;research study;resilience;resilience factor;Risk;Risk Factors;Role;Science;service delivery;side effect;Site;social;social determinants;Socioeconomic Status;success;Surveys;The Multicenter AIDS Cohort Study;Time;tool;Translating;transmission process;treatment adherence;treatment guidelines;Treatment Protocols;United States;uptake;Viral;Virus;Washington;Woman;Women's Interagency HIV Study

PROJECT_TITLE: Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ISLAM, SHAHIDUL  (contact)

PROJECT_TERMS: Biogenesis;Bioinformatics;Biometry;Catabolism;cluster computing;Collaborations;Competence;Consultations;Data;Data Analyses;Data Analytics;Data Collection;data curation;data management;data quality;Data Reporting;Data Set;data sharing;data standards;Dedications;Elements;Ensure;High Performance Computing;Human Resources;instrument;Lipoproteins;meetings;member;Methodology;Methods;Mus;novel;Outcome Study;Play;Policies;power analysis;Process;programs;Protocols documentation;Publications;Quality Control;Reporting;repository;Research Design;Role;Running;Sample Size;Sampling;sound;Source;Standardization;Statistical Data Interpretation;Statistical Methods;success;System;Techniques;Validation;Work

PROJECT_TITLE: Biostatistics and Bioinformatics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The objective of this research program is to invent catalytic synthetic protocols for the creation of new, high-value materials for application in biomedicine. We will use the powerful tools of medicinal chemistry (e.g. asymmetric catalysis and late-stage functionalization) to generate stereochemically and functionally diverse polymeric substrates that can be exploited in the pursuit of next-generation degradable or functional medical devices.

PI_NAMEs: LEIBFARTH, FRANK ALBERT (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Stereoselective Polymerization Methods for the Synthesis of Degradable Biomaterials

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


PI_NAMEs: PEACOCK, JANET L (contact)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Award;biobank;Bioinformatics;biological sex;career;career development;Centers of Research Excellence;clinical biomarkers;clinical epidemiology;Collaborations;Communication;Communities;Core Facility;Data;Discipline;Disease;Disease Pathway;disorder risk;Early identification;Eligibility Determination;Ensure;Environment;Epidemiologist;epidemiology study;equity, diversity, and inclusion;Etiology;experience;Extramural Activities;Feedback;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Grant;Growth;Health;health inequalities;high reward;high risk;Human;human disease;improved;Institution;Investigation;Investments;Leadership;Letters;Manuscripts;Measures;member;Mentors;Mentorship;metabolomics;Metagenomics;Methodology;Methods;Mission;Modification;Molecular;Molecular Epidemiology;multidisciplinary;New England;Pathogenesis;Peer Review;Phase;Pilot Projects;Population;Principal Investigator;Process;Productivity;programs;Publications;Publishing;Recommendation;Reduce health disparities;Research;research and development;Research Design;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Self Efficacy;sex as a biological variable;Study Section;success;Surveys;Talents;Techniques;Technology;Time;tool development;Training;Underrepresented Populations;United States National Institutes of Health;Vocational Guidance;Vulnerable Populations;Work;Writing

PROJECT_TITLE: Pilot Project Program


PI_NAMEs: ALEMAN, JOSE ORLANDO (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;analytical method;analytical tool;Apolipoproteins;Apolipoproteins B;Arterial Fatty Streak;Atherosclerosis;Basic Science;Biogenesis;Bioinformatics;bioinformatics tool;Biological Assay;Biology;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Catabolism;Centrifugation;Ceramides;Clinical;clinical application;clinical practice;clinical risk;clinically relevant;cohort;Communities;cost effectiveness;Data;Data Set;Diabetes Mellitus;extracellular vesicles;Family;Fasting;Gastrectomy;Goals;Health;Human;human tissue;Hypertriglyceridemia;Individual;Institution;instrumentation;interest;Laboratories;Lasers;lipidomics;Lipids;Lipoproteins;Liver;Macrophage;Mass Spectrum Analysis;Metabolism;metabolomics;Methods;Molecular;Molecular Sieve Chromatography;mouse model;Mus;novel;Obesity;Outcome;particle;phenotypic data;Plasma;pre-clinical;Procedures;Process;Protein Family;Proteins;Proteomics;Regulation;Research;Research Personnel;Risk;Risk Marker;Risk Reduction;Role;Sampling;Services;Standardization;Systems Biology;Technology;Tissues;Translating;Triglycerides;Ultracentrifugation

PROJECT_TITLE: Human Tissues, Lipidomics, and Proteomics Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_DEPT: PATHOLOGY

PHR: Prion diseases are rapidly progressive, fatal neurodegenerative disorders caused by aggregated prion protein. We have found that shortening extracellular glycosaminoglycans (GAGs) in the brain can enhance prion clearance and prolong survival. The proposed studies are expected to reveal mechanisms underlying how prions form plaques in the brain parenchyma and vasculature as well as test strategies to promote clearance, towards a goal of reducing plaque burden and slowing disease.

PI_NAMEs: ESKO, JEFFREY D;RAVITS, JOHN ;SIGURDSON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;Address;Affect;Affinity;alpha synuclein;Alzheimer's Disease;Alzheimer's disease patient;Amino Acid Sequence;Amino Acids;Amyloid;Amyloid beta-Protein;Antisense Oligonucleotides;Asparagine;Astrocytes;astrogliosis;Automobile Driving;Binding;Binding Proteins;Biological Assay;Biological Models;Blood;Blood Vessels;Brain;brain parenchyma;Cells;Central Nervous System;Cerebral Amyloid Angiopathy;Cerebrovascular system;Cessation of life;chemical property;cofactor;Collaborations;Creutzfeldt-Jakob Syndrome;Data;Deposition;Development;Disease;disease model;disease phenotype;Disease Progression;efficacy testing;Endothelium;Enzymes;extracellular;Funding;Gene Modified;genetic manipulation;Gliosis;Glutamine;Glycosaminoglycans;glycosylation;Goals;Heparan Sulfate Biosynthesis;Heparitin Sulfate;In Vitro;in vivo;in vivo Model;insight;Intercellular Fluid;Knock-in Mouse;Length;Link;Location;Messenger RNA;Modification;Molecular;Molecular Conformation;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Symptoms;neuron loss;Neurons;Pathologic;Pathology;Patients;polyanion;Polysaccharides;Post-Translational Protein Processing;Prion Diseases;Prions;protein expression;protein structure;Proteins;PrP;Radiolabeled;Role;scaffold;self assembly;Senile Plaques;Sialoglycoproteins;Structural Biologist;structural determinants;Sulfate;sulfurtransferase;Symptoms;Synapses;tau Proteins;Testing;Therapeutic;therapeutic target;Transgenic Organisms;transmission process;Tropism

PROJECT_TITLE: Mechanisms of Prion Aggregation

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


PI_NAMEs: FISHER, EDWARD A (contact)

PROJECT_TERMS: analytical tool;Aorta;Arterial Fatty Streak;Arteries;Atherosclerosis;Biogenesis;Bioinformatics;Biology;Biometry;Catabolism;Cell Compartmentation;cell type;Cells;Characteristics;Confocal Microscopy;cost effectiveness;Data;data management;Digestion;Endothelial Cells;Ensure;experimental study;Family;Gene Expression;Gene Expression Profiling;Genomics;Histologic;histological stains;Immunohistochemistry;instrumentation;Laboratories;laser capture microdissection;Lesion;Lesion by Morphology;Lipids;Lipoproteins;Macrophage;Metabolic;Molecular;Myeloid Cells;novel;Population;Procedures;Process;Program Research Project Grants;Reproducibility;Research Personnel;Sampling;Services;single-cell RNA sequencing;Stains;Standardization;Techniques;Technology;tissue preparation;Tissues;transcriptome sequencing;Valsalva sinus

PROJECT_TITLE: Atherosclerosis core


PROJECT_TERMS: Ablation;adipocyte biology;Adipocytes;Adipose tissue;Affect;Anti-Inflammatory Agents;Apolipoproteins B;Atherosclerosis;Binding;Binding Proteins;Biogenesis;Bioinformatics;biological adaptation to stress;Biology;Biometry;Blood;Blood Vessels;Body Weight decreased;Cardiovascular Diseases;cardiovascular risk factor;Catabolism;Cause of Death;Cells;Cholesterol;Collaborations;cytokine;Cytosol;Deposition;diet-induced obesity;druggable target;Endoplasmic Reticulum;Endothelial Cells;Energy Metabolism;Fatty acid glycerol esters;Fatty Liver;Genes;Heart Diseases;Hepatic;Human;Hydrolysis;Hypertriglyceridemia;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Integral Membrane Protein;Knock-out;Link;Lipase;lipid metabolism;lipidomics;Lipids;Lipolysis;Lipoproteins;Liver;Macrophage;Measures;Membrane;Metabolism;microsomal triglyceride transfer protein;Monitor;mouse model;Mus;novel;obese patients;Obesity;oxidation;Pathogenicity;Pathology;Phenotype;Plasma;Production;Protein Deficiency;protein function;Proteins;Proteomics;Regulation;Resistance;RNA analysis;Role;Route;Sampling;single-cell RNA sequencing;Site;Testing;tool;transcriptome sequencing;Translating;Triglycerides;uptake;Very low density lipoprotein;Weight Gain;Work

PROJECT_TITLE: Adipose MTP and FIT2 in the regulation of plasma lipids, obesity and atherosclerosis


NIH_SPENDING_CATS: Atherosclerosis;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

PROJECT_TERMS: Adipocytes;Adipose tissue;Apoprotein (B);atherogenesis;Atherosclerosis;bariatric surgery;Biogenesis;Biological Assay;Biology;Body Weight decreased;Catabolism;Cells;Cholesterol Esters;Chylomicrons;Circulation;Collaborations;Complement;Core Facility;Cytoplasm;Data;defined contribution;Degradation Pathway;Diglycerides;Encapsulated;Endoplasmic Reticulum;endoplasmic reticulum stress;Enterocytes;Event;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Gene Expression;Generations;Golgi Apparatus;Hepatic;Hepatocyte;Hypertriglyceridemia;In Vitro;in vivo;Kinetics;Knockout Mice;Link;Lipids;Lipolysis;Lipoproteins;Liver;Membrane;Membrane Lipids;Metabolic;microsomal triglyceride transfer protein;Molecular;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;Names;non-alcoholic fatty liver disease;novel;obese patients;Outcome;Output;particle;Pathogenicity;Pathway interactions;Peripheral;Play;Proteins;Publications;Quality Control;Regulation;Repression;Role;Site;Smooth Endoplasmic Reticulum;Source;Steatohepatitis;synergism;System;Testing;Tissues;trafficking;Transcript;Transferase;Translating;Triglycerides;Very low density lipoprotein;Vesicle;vesicle transport;Work

PROJECT_TITLE: Novel regulatory mechanisms controlling hepatic apoB-Lp lipid loading and secretion


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PHR: HIV-ME R01 Study Narrative Great strides have been made in the technology that allows us to use HIV genetic sequence information to analyze and track how HIV is transmitted within populations and between individuals. More accurate information about HIV transmission may help efforts to reduce the spread of HIV but may also increase the risk to participants involved in the research. This project will measure both the risks and benefits of using this technology for HIV prevention research and then gauge the acceptability of these approaches in key stakeholder groups living with HIV and at risk for HIV infection across the United States.

PI_NAMEs: LITTLE, SUSAN JANET (contact);SUGARMAN, JEREMY

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Affect;AIDS prevention;Area;Attenuated;Attitude;Belief;Benefits and Risks;Centers for Disease Control and Prevention (U.S.);Communicable Diseases;Communities;Criminal Law;Data;data sharing;deliberative democracy;design;Diagnosis;Disease Outbreaks;disease transmission;Emerging Technologies;Epidemic;epidemiologic data;Epidemiology;ethical, legal, and social implication;experience;Genetic;Geographic Locations;Goals;Healthcare Systems;HIV;HIV Infections;implementation barriers;improved;Individual;Injecting drug user;innovation;Investigation;Laboratories;Legal;Link;Measurable;Measures;Medical;men who have sex with men;Methods;Molecular;Molecular Epidemiology;Participant;pathogen;Persons;Policy Developments;Population;Populations at Risk;Prevention Research;Prevention strategy;preventive intervention;prospective;Public Health;Publications;Qualitative Methods;Reporting;Research;Research Personnel;Risk;Risk Estimate;risk stratification;simulation;social stigma;Spottings;stakeholder perspectives;standard of care;success;Surveillance Program;System;Technology;Time;transgender women;transmission process;United States;working group

PROJECT_TITLE: Risks, Benefits, and Stakeholder Perspectives of Molecular Epidemiology for HIV Prevention (HIV-ME)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Racial and ethnic minority young adults in the U.S. are at increased risk for premature discontinuation of treatment for serious mental illness. Despite the significant public health impact of untreated mental illness, there are no evidence-based treatment engagement interventions explicitly designed to be culturally- responsive to this population. The proposed study partners with racial and ethnic minority young adults with serious mental illness to adapt and test a brief intervention that incorporates their unique developmental and cultural preferences to improve their engagement in treatment and decrease mental health disparities.

PI_NAMEs: MOORE, KIARA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;aged;Area;Award;Behavioral;Belief;brief intervention;care systems;career;Clinical;Clinical Trials;Collaborations;Complex;Data;Decision Making;design;Development;Discrimination;disparity reduction;distrust;Economics;Educational Curriculum;emerging adult;Ensure;ethnic minority;Ethnic Population;evidence base;Evidence based intervention;Evidence based treatment;experience;Experimental Designs;experimental study;feasibility trial;Feeling;Formulation;Funding;Goals;Grant;health communication;health determinants;Health Disparities Research;health disparity;Health Personnel;health service use;Health Services Research;Healthcare;high risk;Imprisonment;improved;Inequity;Intake;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lead;Letters;Mental disorders;Mental Health;Mental Health Services;Mentors;Methods;minority children;Minority Groups;Modification;mortality;multi-component intervention;multiphase optimization strategy;National Institute of Mental Health;New York City;Not Hispanic or Latino;novel;Participant;patient oriented research;peer;person centered;personal narratives;personalized approach;Persons;pilot test;Population;Population Heterogeneity;post intervention;Poverty;preference;premature;Preparation;Process;programs;Provider;psychiatric rehabilitation;Public Health;racial minority;racial population;Recovery;Reporting;Research;Research Activity;Research Personnel;Risk;role model;Sampling;Self Efficacy;service engagement;service utilization;Services;severe mental illness;skills;social stigma;socioeconomic disadvantage;structural determinants;Testing;therapy development;Training;transition to adulthood;treatment disparity;Trust;Uncertainty;Underserved Population;Work;Writing;young adult;Youth

PROJECT_TITLE: Adapting and Testing A Mental Health Services Engagement Program for Racial and Ethnic Minority Young Adults

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE The proposed research study aims to use recent advances in causal machine learning methods to determine the influence of e-cigarettes (EC) use on subsequent combustible cigarette smoking in the overall US youth and adult populations and in vulnerable subgroups, and to evaluate methods for generalizable EC exposure effects. Study findings will inform tobacco product regulators whether and among whom EC use has an impact on cigarette smoking. This effort may lead to a better understanding of the causal processes underlying EC use, and ultimately, inform evidence-based regulation and policy making.

PI_NAMEs: XU, SHU  (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: Address;Adult;Age;American;Area;Award;Bayesian Network;Behavior;Behavioral Research;Characteristics;Cigarette;Cigarette Smoker;cigarette smoking;combustible cigarette;Complex;complex data;Data;Data Analyses;Electronic cigarette;electronic cigarette use;Entropy;Ethnic Origin;evidence base;experience;forest;Gender;Goals;Health;health disparity;Heterogeneity;high dimensionality;Institution;intersectionality;Knowledge;Learning Skill;Literature;longitudinal analysis;Longitudinal Studies;Machine Learning;machine learning method;Measures;Mentors;Methods;Modeling;multidimensional data;Observational Study;Performance;Pilot Projects;Policy Making;Population;Population Analysis;Population Assessment of Tobacco and Health;Poverty;Process;Race;Regression Analysis;regression trees;Regulation;Research;Research Design;Research Personnel;Research Priority;research study;response;Risk;Science;Scoring Method;secondary analysis;Selection Bias;Smoke;Smoker;Subgroup;Surgeon;theories;Time;Tobacco;tobacco prevention;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;Vulnerable Populations;Youth

PROJECT_TITLE: Using Causal Machine Learning Methods to Inform Tobacco Regulatory Science


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

PI_NAMEs: GOLDBERG, IRA J (contact)

PROJECT_TERMS: Acceleration;Activins;Adipocytes;Affect;Apolipoproteins B;Arteries;Atherosclerosis;bafilomycin A;Binding;Biogenesis;Biology;Blood;Blood Vessels;Cardiovascular Diseases;Catabolism;Cells;Cellular biology;Cellular Metabolic Process;Characteristics;Cholesterol;Chronic;Chylomicrons;Data;Development;endothelial cell scavenger receptor;Endothelial Cells;Endothelium;Enterocytes;Event;extracellular vesicles;Fasting;Fatty acid glycerol esters;feeding;Gene Expression;Genes;Goals;Hepatic;Hepatocyte;Human;impression;In Vitro;in vivo;Inflammation;Inflammatory;Intestines;Knock-out;Knockout Mice;Ligand Binding;Link;lipidomics;Lipids;Lipolysis;lipoprotein lipase;Lipoproteins;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Lysosomes;Macrophage;Mediating;microsomal triglyceride transfer protein;Movement;Mus;N-terminal;novel;novel strategies;Pathway interactions;Peptides;Phosphotransferases;Postprandial Period;Prevention;Process;Production;Protein Deficiency;Proteomics;receptor;Reporting;Research Personnel;RNA;Role;single cell analysis;Site;Source;SR-BI receptor;Testing;Tissues;transcytosis;Triglycerides;uptake;Vascular Diseases;vascular inflammation;Very low density lipoprotein;western diet

PROJECT_TITLE: Blood TG clearance and vascular biology


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Studies from the last several years have highlighted the importance of long noncoding RNAs in human development, health, and diseases such as cancer and atherosclerosis, but the mechanisms by which RNAs effect epigenetic change remain largely unknown. X-chromosome inactivation serves as an excellent model to study RNA regulation because this process is controlled by a series of RNA-based switches. Our proposed research will dissect mechanisms of RNA regulation by investigating its role in chromosome pairing, gene silencing, and imprinting.

PI_NAMEs: LEE, JEANNIE T (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alleles;Atherosclerosis;autosome;Biological Models;Biology;career;Cell model;Cells;Chromatin Loop;Chromosome Pairing;cohesin;Complex;Data;Daughter;decapping enzyme;Development;Disease;Elements;Embryo;Enhancers;Ensure;Epigenetic Process;epigenetic regulation;epigenomics;Funding;Future;gene repression;Gene Silencing;Genes;genome-wide;Germ Cells;Germ Lines;Grant;Health;Human Development;imprint;in vivo;Inherited;Knockout Mice;Learning;Link;male;Malignant Neoplasms;Measures;Meiosis;Modeling;Molecular;mRNA decapping;Mus;neuronal cell body;Paint;Pathway interactions;permissiveness;Placenta;Play;Postdoctoral Fellow;Process;promoter;Proteins;Pseudoautosomal Region;recruit;Regulation;release factor;Repression;Research;RNA;RNA Degradation;Role;Series;Sex Chromosomes;Site;stem cell model;Technology;Titrations;Training;Transgenic Organisms;trophoblast stem cell;United States National Institutes of Health;Untranslated RNA;Up-Regulation;Visit;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Regulation of X-chromosome inactivation and imprinting by non-coding elements

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Orphan Drug;Prostate Cancer;Radiation Oncology;Rare Diseases;Urologic Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE Currently, the most effective therapy for head and neck cancer and prostate cancer is X-ray (photon) or proton- based radiotherapy, given at conventional dose rates with or without systematic therapy, but this therapy comes at the cost of both acute and late toxicity that worsen quality of life and can contribute to mortality and high treatment cost. We propose that ultrahigh dose rate “FLASH” delivery of X-ray or proton irradiation (dose rate ≥40 Gy/s vs ~0.1 Gy/s) can deliver curative doses to tumors in milliseconds while mitigating normal tissue damage, and subsequently reducing the cost. Our long-term objective is to establish a foundation for the clinical use of FLASH radiation to improve tumor and normal tissue outcomes in head and neck and prostate cancer.

PI_NAMEs: FRANK, STEVEN JAY (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acute;Address;Affect;Animal Cancer Model;anti-cancer treatment;BALB/c Nude Mouse;Biological;Biological Models;C3H/HeJ Mouse;Cells;Clinical;clinical effect;Colitis;conventional dosing;cost;Cystitis;Dose;Dose Rate;effective therapy;Electrons;Ensure;experience;experimental study;External Beam Radiation Therapy;Fibrosis;Foundations;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;high reward;high risk;Histology;Human;Image;improved;improved outcome;In Vitro;in vivo;in vivo Model;individual patient;irradiation;Knowledge;Malignant Epithelial Cell;Malignant neoplasm of prostate;Malignant Neoplasms;millisecond;Modeling;Modernization;mortality;Motion;Movement;Mucositis;Mus;Normal tissue morphology;novel;novel therapeutic intervention;Operative Surgical Procedures;Organ;Outcome;Pathologist;Patient-Focused Outcomes;Patients;PC3 cell line;Pelvis;Photons;physical property;Physicians;Positioning Attribute;pre-clinical;preclinical study;preservation;Prostate;Prostate Adenocarcinoma;prostate cancer model;protective effect;Protons;Qualifying;Quality of life;Radiation;Radiation Dose Unit;Radiation therapy;Reproducibility;Research;Resources;response;Roentgen Rays;Scientist;Site;sound;Systemic Therapy;Taste Buds;Testing;Time;tissue repair;Tissues;Tongue;Toxic effect;Treatment Cost;treatment duration;Treatment Efficacy;Treatment outcome;Treatment Side Effects;Treatment-related toxicity;tumor;Tumor Tissue;tumor xenograft;Work;Xenograft procedure

PROJECT_TITLE: Investigating the Effect of FLASH-Radiotherapy on Tumor and Normal Tissue


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cocaine;Drug Abuse (NIDA only);Emergency Care;Fentanyl Misuse and Addiction;Health Services;Methamphetamine;Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prescription Drug Misuse;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE  While a large body of research has demonstrated high risk patterns of prescription opioid use predicts overdose, the role of prescription stimulants on the drug overdose epidemic is understudied. Using novel comprehensive state-wide datasets from Oregon and Massachusetts, the proposed research will fill a critical gap by assessing the impact of prescription stimulant use on drug overdoses. By identifying prescribing patterns with protective or harmful effects on rates of drug overdoses, evidence generated from these studies could lead to changes in policy, early intervention with patients at risk of overdose, and public health initiatives such as continuing medical education activities or updated clinical guidelines that promote safe prescribing of stimulants with goal of mitigating stimulant-related overdose.

PI_NAMEs: DE NADAI, ALESSANDRO STEVENS (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;Acceleration;Accident and Emergency department;Adherence;Adult;Adverse event;amphetamine use;Amphetamines;Benefits and Risks;Benzodiazepines;case control;Cessation of life;Characteristics;Clinical;Cocaine;Cocaine use disorder;Cohort Studies;Complement 3;Complex;continuing medical education;Control Groups;COVID-19 pandemic;Dangerousness;Data;Data Set;Data Sources;Databases;Death Certificates;design;Dose;Drug abuse;Early Intervention;Educational Activities;Emergency department visit;Emergency medical service;Epidemic;evidence base;Fentanyl;fentanyl contamination;follow-up;Future;Goals;Guidelines;Heroin;heroin use;Heterogeneity;high risk;Hospitals;Individual;innovation;Inpatients;Interdisciplinary Study;Internet;Knowledge;Link;Longterm Follow-up;Massachusetts;medication for opioid use disorder;Methamphetamine;Methamphetamine use disorder;Methods;Modeling;National Institute of Drug Abuse;NIH Program Announcements;novel;Observational Study;Opioid;opioid epidemic;opioid overdose;opioid use;opioid use disorder;Oregon;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;Patients;Pattern;Pharmaceutical Preparations;Pharmacy facility;Phase;pill;Policies;polysubstance use;prescription monitoring program;prescription opioid;prescription stimulants;prevent;protective effect;Provider;psychostimulant;Public Health;randomized placebo controlled trial;Recording of previous events;Records;Research;response;Risk;Risk Assessment;Role;Sample Size;Stimulant;Stimulant overdose;stimulant use;stimulant use disorder;substance abuse treatment;Substance Use Disorder;substance use treatment;telehealthcare;Therapeutic;Time;Toxicology;Translating;United States;Update;Work

PROJECT_TITLE: Impact of prescription stimulants on the drug overdose epidemic


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative (Public Health Relevance Statement) In spite of the essential role of NPR1 (NONEXPRESSOR OF PATHOGENSIS-RELATED GENES 1) as a master regulator of the salicylic acid (SA)-mediated immune response in plants, the molecular mechanism of its function has remained poorly understood. Genetically engineered crops through enhancement of the NPR1-mediated innate immunity display broad-spectrum disease resistance without compromising plant fitness, leading to a decreased usage of pesticides and reduction of the selective pressure for pesticide-resistant pathogens. As SA and derivatives, such as aspirin (acetylsalicylate), have numerous health benefits in humans, including fever reduction and pain relief, as well as decreased death tolls from cardiovascular diseases and cancers, a thorough understanding the SA-NPR1 signaling pathway in plants may also bear significant implications in understanding the medicinal consequence of these molecules against a variety of human diseases.

PI_NAMEs: ZHOU, PEI  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Achievement;Agriculture;analog;Ankyrin Repeat;Arabidopsis;Architecture;Aspirin;Binding;Biochemical;Biological Process;Biological Response Modifiers;Biology;Birds;BTB/POZ Domain;C-terminal;Cardiovascular Diseases;Cell Nucleus;Cell Survival;Cells;Cessation of life;circadian regulation;Circadian Rhythms;cofactor;Complex;Cryoelectron Microscopy;CUL3 gene;Cullin Proteins;cullin-3;Cytoplasm;dimer;Dimerization;Disease;Disease Resistance;Dissociation;disulfide bond;DNA Binding Domain;Endoplasmic Reticulum;Ensure;Event;Fever;fitness;Gene Activation;Gene Expression;Genes;Genetic;Genetic Engineering;Genetic Transcription;genome-wide;Goals;Health Benefit;Human;human disease;Immune response;Immunity;insight;Investigation;Knowledge;Length;Malignant Neoplasms;Masks;Mediating;Medicine;Molecular;Molecular Conformation;Mouse-ear Cress;mutant;N-terminal;Natural Immunity;Nature;Nuclear;Nuclear Translocation;Oxidation-Reduction;pain relief;particle;pathogen;Pathogenesis;Pathogenicity;pesticide resistance;Pesticides;Phase;Plant Diseases;Plants;Polyubiquitination;pressure;prevent;Process;Proteins;proteotoxicity;public health relevance;receptor;Recombinants;recruit;Regulation;Resistance;Resolution;response;Rest;Role;Salicylic Acids;Signal Pathway;Signal Transduction;Stress;Structure;success;Testing;Transcription Coactivator;transcription factor;Transcription Repressor;transcriptional reprogramming;ubiquitin-protein ligase;Visualization;Wing

PROJECT_TITLE: Mechanistic Insights into the Plant Disease Resistance Mediated by NPR1

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Rehabilitation

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The number of individuals with disabilities and the extent of the disabilities continue to increase with a clear impact on the need for developing better and more effective rehabilitation interventions. The proposed pre- and post-doctoral program will train rehabilitation scientists based on solid fundamental science principles combined with engineering methods to allow them to establish successful research programs that translate into effective rehabilitation interventions and more importantly, are transferred to the clinic.

PI_NAMEs: HECKMAN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TITLE: Research Training in Sensorimotor Neurorehabilitation


NIH_SPENDING_CATS: Lung;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative. The proposed research is relevant to public health because it the first preclinical model of Pulmonary Langerhans Cell Histiocytosis (PLCH). This project will address the function and significance of myelo-monocytic cells and their expression of both soluble and cell surface ligands responsible for the generation of inflammatory lesions in PLCH patients The successful completion of this project is expected to reveal novel insight into disease development and progression, identify new targets aimed at decreasing morbidity and mortality, and test the potential possibility of immune function inhibition as a possible treatment for PLCH patients.

PI_NAMEs: BORCHERS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Adoptive Transfer;Benign;Biological;Biological Assay;Biopsy;Blocking Antibodies;BRAF gene;CCL20 gene;CCL7 gene;Cell Aging;Cell Maturation;Cell surface;Cell Therapy;Cells;chemokine;Chronic;Cigarette Smoker;Clinical Trials;Communities;Cyst;Cystic Lesion;cytokine;Cytolysis;cytotoxic;cytotoxicity;Data;Dendritic Cells;Development;Diagnosis;Disease;effective therapy;Eosinophilic Granuloma;Event;evidence base;Exhibits;experimental study;Exposure to;exposure to cigarette smoke;Generations;Goals;histiocyte;Homeostasis;Human;Immune Evasion;immune function;In Vitro;Induced Mutation;Inflammation;Inflammatory;insight;Interstitial Lung Diseases;ITGAX gene;Knowledge;langerin;Lesion;Leukocytes;Life;Ligands;Link;Lung;Lung Diseases;lung lesion;Lymphocyte;Lymphokine-Activated Killer Cells;MAPK Signaling Pathway Pathway;Mediating;Modeling;Molecular;Molecular Target;monocyte;Morbidity - disease rate;mortality;Mus;mutant;Mutant Strains Mice;Mutation;Myelogenous;Nature;Neoplasms;Nodule;novel;novel therapeutics;Pathogenesis;Pathology;Pathway interactions;Patients;Phosphotransferases;Pre-Clinical Model;preclinical study;preservation;Process;Production;Public Health;receptor;recruit;Reporting;Research;Role;Source;Specificity;Testing;therapeutic target;therapy development;Time;Up-Regulation

PROJECT_TITLE: Molecular and Cellular Pathogenesis of Pulmonary Langerhans Cell Histiocytosis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This research directly addresses the current limitations of stem cell-based ocular surface therapies and the lack of viable inventions for restoring the limbal niche environment in patients with limbal stem cell deficiency. Results from this study will help drive new clinical applications for Descemet’s membrane on the ocular surface, as a novel limbal niche surrogate for supporting cultured limbal stem cell transplantation. Short-term, this will help improve therapeutic outcomes for patient’s blinded by limbal stem cell deficiency; long-term, this will help inform future research into alternative limbal niche surrogates for ocular surface reconstruction.

PI_NAMEs: HOU, JOSHUA H (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: ABCG2 gene;Address;Age related macular degeneration;Air;Animal Model;Anterior;Autoimmune Diseases;Basal Cell;Basement membrane;Biological;Biological Assay;Biological Markers;Blinded;Blindness;cell regeneration;Cell Transplantation;Cells;Characteristics;Chemical Burns;Chemical Injury;Clinic;clinical application;Collagen Type IV;collagenase;Communication;comparative;comparative efficacy;Competence;conjunctiva;Cornea;corneal epithelium;corneal regeneration;Defect;Descemet's membrane;Development;Digestion;Disease;Effectiveness;Engineering;Environment;Epithelial Cells;Extracellular Matrix;Extracellular Matrix Proteins;Eye diseases;fetal;Future;Goals;graft failure;Human;human induced pluripotent stem cells;immunodeficiency;Immunohistochemistry;improved;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;invention;Lifting;limbal;Mechanics;melting;Membrane;Membrane Proteins;Mentored Clinical Scientist Development Program;Mentors;Minnesota;Modeling;mouse model;Natural regeneration;novel;ocular surface;Operative Surgical Procedures;Optics;Oral;Organ Culture Techniques;Outcome;Pain;Patient-Focused Outcomes;Patients;personalized medicine;Phenotype;Physiologic pulse;Physiological;pluripotency;Population;programs;Proliferating;Proteins;Protocols documentation;Publishing;Quantitative Reverse Transcriptase PCR;Rattus;reconstruction;Recurrence;regenerative therapy;Rehabilitation therapy;Reporting;Research;Research Personnel;research study;Resistance;Resources;skills;stem cell biomarkers;stem cell function;Stem cell transplant;stem cells;stemness;success;Surface;Testing;Therapeutic Intervention;therapy outcome;Time;Tissue Donors;tissue processing;Training;Transplantation;Universities;Vitronectin;Work;Writing

PROJECT_TITLE: Ocular surface applications of Descemet's membrane


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Patient Safety;Prevention;Primary Health Care

ORG_CITY: BALTIMORE

ORG_DEPT: GENETICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While there are effective treatments for prediabetes including the intensive lifestyle program, Diabetes Prevention Program (DPP), enrollment and uptake of these programs are low. Research from our team and others has shown that patient barriers to addressing prediabetes include inadequate knowledge, difficulty with maintaining discipline and motivation, and psychosocial stressors, all of which lead to lower patient activation, a key driver of positive health outcomes. With this proposal, we will develop a prediabetes digital patient activation tool that aims to increase patient activation and thereby uptake of treatments like the DPP which have been shown to decrease the risk of progression to diabetes.

PI_NAMEs: TSENG, EVA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adult;Affect;Algorithms;Applications Grants;Assessment tool;Behavior;Behavioral;Blood Pressure;Body mass index;Body Weight decreased;Caring;Case Manager;Clinic;Clinical;Clinical Pathways;clinical practice;Data;Decision Aid;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;digital;Discipline;effective therapy;effectiveness testing;Electronic Health Record;Elements;Eligibility Determination;empowerment;Enrollment;evidence base;experience;Funding;Goals;Health;health service use;Health system;high risk;improved;Incidence;Individual;Interview;Investments;Knowledge;Lead;Life Style;lifestyle intervention;Measures;Methods;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Nurses;Nutritionist;Outcome;Outcome Measure;Participant;Patient Education;patient engagement;patient health information;Patient Outcomes Assessments;patient portal;Patient Preferences;Patient Self-Report;patient-level barriers;Patients;Persons;Physical activity;Pilot Projects;pilot test;Play;Prediabetes syndrome;prevent;primary care clinic;primary care clinician;Primary Care Physician;primary outcome;programs;progression risk;psychosocial stressors;Public Health;Questionnaires;Randomized, Controlled Trials;Readiness;Recommendation;Reporting;Research;Resources;response;Risk;Risk Reduction;Role;satisfaction;Self Efficacy;Self Management;shared decision making;Target Populations;Time;tool;Training;treatment as usual;uptake;Visit;Weight;Weight Gain;Work

PROJECT_TITLE: Design and Pilot Test of A Prediabetes Digital Patient Activation Tool

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Aging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Prevention

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

PHR: Project Narrative Nonalcoholic fatty liver disease (NAFLD) is the most prevalent form of liver disease worldwide and is estimated to affect nearly a third of the population. Although its underlying mechanisms remain incompletely understood, aging is known to play a major role in the development of NAFLD. The proposed research will investigate the mechanism of age-associated NAFLD using mouse models. 1

PI_NAMEs: KUROKAWA, MANABU  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: ADD-1 protein;Affect;Age;age related;Aging;Animal Model;Body Weight;Body Weight decreased;CD36 Antigens;Characteristics;Cholesterol;Chronic;Cirrhosis;Clinical;Coupled;Data;data modeling;Deposition;Development;Diet;diet and exercise;Disease;Etiology;Exercise;Fatty acid glycerol esters;Fatty Acids;Fatty Liver;FDA approved;Fibrosis;Goals;Heavy Drinking;Hepatic;Hepatocyte;hepatocyte injury;high risk;Homeostasis;human disease;in vivo;Individual;Inflammation;inhibitor;Knock-out;knockout gene;Knockout Mice;Label;lifestyle intervention;lipid biosynthesis;lipid metabolism;Lipids;Liver;Liver diseases;liver injury;MCL1 gene;Measures;Mediating;Mediator;Medical;Metabolic;Molecular;mouse model;Mus;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Normal tissue morphology;novel;Ohio;Outcome;Pathogenesis;Pathology;Pathway interactions;Physiological;Play;Population;prevent;Primary carcinoma of the liver cells;protein degradation;Proteins;Proteomics;Quality Control;Regulation;Research;Resistance;Risk;Risk Factors;Role;Signal Pathway;Signaling Molecule;Specialist;Tamoxifen;Techniques;Testing;Therapeutic;therapeutic target;Time;TP53 gene;transcription factor;transcriptome sequencing;Triglycerides;ubiquitin-protein ligase;Ubiquitination;Universities;uptake

PROJECT_TITLE: Role of the ubiquitin E3 ligase HUWE1 in age-associated nonalcoholic fatty liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: There is a critical shortage of physician-scientists to address the significant problems caused by child and adolescent mental health illness. This proposed research program will fill a critical gap in training and a national need. Our program will pair substantial dedicated research time with excellent clinical training in our child and adolescent psychiatry fellowship.

PI_NAMEs: BROWN, LARRY K (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Acceleration;Address;Adolescent;adolescent mental health;Adolescent Psychiatry;Advisory Committees;AIDS prevention;Area;Benchmarking;career;career development;Child;Child Development;Child Mental Health;Child Psychiatry;Childhood;Clinical;clinical training;Competence;Contracts;curriculum development;Dedications;didactic education;disability;Education Projects;education research;Educational Curriculum;effective therapy;Environment;Equilibrium;Evaluation;experience;Faculty;Family;Feedback;Fellowship;Fostering;Funding;Future;Genetic;Goals;Grant;hands on research;health disparity;Health Services Research;HIV;improved;Infant Development;interest;Intervention;Interview;Leadership;Learning;medical schools;Mental disorders;Mentors;Mentorship;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Mental Health;Needs Assessment;Neurosciences;next generation;novel;Pathway interactions;Physicians;Post Graduate Year;Prevention;Process;Productivity;programs;Psychiatry;Psychopathology;Psychophysiology;Qualifying;Recording of previous events;recruit;Research;Research Personnel;Research Training;Residencies;Scientist;skills;Sleep;Social Sciences;Student Loan;symposium;Time;Training;Training Programs;Translating;translational neuroscience;Wages;Writing

PROJECT_TITLE: Promoting Child and Adolescent Research During Training


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Alzheimer’s Disease and Related Dementias (ADRD) is a substantial and rapidly-growing public health burden, with no available disease-modifying treatments. Well-being is an understudied but important protective factor against ADRD risk and progression, given that it has been associated with ADRD risk and is amenable to intervention. The planned research will examine multiple types of well-being as predictors of cognitive resilience to ADRD neuropathology as well as bidirectional associations between well-being and cognitive decline.

PI_NAMEs: WILLROTH, EMILY C (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adult;Aging;Agreement;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;Area;Autopsy;Award;Blood Vessels;Brain Pathology;Buffers;career;causal model;Cognitive;cognitive function;Collaborations;comorbidity;Data;Data Analyses;data analysis pipeline;Data Collection;Dementia;dementia risk;demographics;design;Diagnosis;Disease;Education;end of life;Environment;Epidemiologist;Etiology;experience;Health;Health behavior;hedonic;hippocampal sclerosis;Impaired cognition;improved;Individual;Intervention;Knowledge;Lewy Bodies;Lewy Body Disease;Life;life span;Link;longitudinal dataset;Longitudinal Studies;Measures;Medical;medical schools;Memory;Mentors;Mentorship;Modeling;negative affect;Neurobehavioral Manifestations;Neurofibrillary Tangles;neuropathology;older adult;Pathology;Pathway interactions;Personal Satisfaction;Personality;physical conditioning;Physiological Processes;Predictive Factor;prospective;protective factors;protein TDP-43;Psychologist;psychosocial;Public Health;religious order study;Research;Residual state;resilience;Risk Factors;Sampling;satisfaction;Scientist;Severities;skills;Social Sciences;Stress;Symptoms;tau aggregation;tau Proteins;Techniques;Testing;Training;trait;Well in self;Work

PROJECT_TITLE: Well-being as a Protective Factor against Cognitive Decline and Dementia Risk


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BEAVERTON

ORG_NAME: CHILDREN'S CANCER THERAPY DEVELOP/INST

ORG_STATE: OR

PHR: PROJECT NARRATIVE Alveolar rhabdomyosarcoma (ARMS) is a cancer of the soft tissues. This disease often responds to chemotherapy, but in many patients the available treatments fail --a deadly outcome. We identified how a cancer- causing fused gene called PAX3:FOXO1 leads to treatment failure. We have recently published that, remarkably, PAX3:FOXO1 can be silenced by entinostat, a drug recently granted FDA breakthrough designation for breast cancer. We find entinostat dramatically improves response to frontline chemotherapy in human tumors implanted in mice – which has led directly to a Children's Oncology Group Phase I clinical safety trial (now complete) and a phase II clinical trial concept for rhabdomyosarcoma patients. In considering the more expansive Phase II clinical trial, we ask: can we get insight into sensitivity or resistance by knowing more precisely how entinostat works, and can a chemotherapy effectively be combined with entinostat? Answering these questions will pave the way for an evidence-based clinical trial that could save lives.

PI_NAMEs: KELLER, CHARLES  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Alveolar Rhabdomyosarcoma;ATP phosphohydrolase;Automobile Driving;biological adaptation to stress;Biology;Bromodomain;Catalytic Domain;Cell Maintenance;Cell Survival;Cellular Stress;chemotherapy;Chemotherapy and/or radiation;Childhood;Clinical;Clinical Trials;Clinical Trials Cooperative Group;comparative efficacy;Compensation;Complex;Curiosities;Cyclophosphamide;Disease;DNA;Dose;Down-Regulation;Doxorubicin;Drops;efficacy testing;Epigenetic Process;epigenetic regulation;evidence base;Evolution;FOXO1A gene;fusion gene;Gene Fusion;Genetic;Grant;HDAC3 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;Implant;improved;insight;knock-down;loss of function;Maintenance;Malignant Breast Neoplasm;malignant muscle neoplasm;Malignant Neoplasms;Mediating;Messenger RNA;MicroRNAs;Mitotic;Molecular;Mus;Mutation;neoplastic cell;novel;Oncogenes;Outcome;Patients;PAX3 gene;Pediatric Oncology Group;Pharmaceutical Preparations;pharmacologic;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Predisposition;Process;Proteins;Publishing;Qualifying;Recurrence;Relapse;Reporting;Repression;Resistance;response;Rhabdomyosarcoma;Role;Safety;Science;Signal Transduction;small hairpin RNA;SMARCA2 gene;SMARCA4 gene;soft tissue;SWI/SNF Family Complex;synergism;Testing;therapeutic target;therapy resistant;tool;Treatment Failure;treatment response;tumor;tumor initiation;Vincristine;Work

PROJECT_TITLE: Clinical & Mechanistic underpinnings to reducing PAX:FOXO1 for alveolar rhabdomyosarcoma

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]