NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: REYNOLDS, PEGGY  (contact)

PROJECT_TERMS: Affect;Air;Analytical Chemistry;Animal Model;Animals;animation;Area;Back;Basic Science;Bioinformatics;Biological;biological research;burden of chronic illness;Businesses;California;Censuses;Chemical Exposure;Chemicals;Child;Clinical;Clinical Medicine;Clinical Research;Clinical Sciences;Communication;community organizations;Commuting;Complex;Consult;Consultations;Core Facility;Data;Data Analyses;data integration;data resource;Databases;Development;Developmental Biology;Diabetes Mellitus;digital;Discipline;Discipline of obstetrics;Environment;environmental chemical;environmental chemical exposure;environmental chemistry;Environmental Exposure;Environmental Health;Environmental Science;environmental stressor;Epidemiology;epidemiology study;Evaluation;Experimental Models;exposure pathway;Exposure to;farmers markets;food environment;gene environment interaction;Geographic Information Systems;Geography;Goals;Green space;Gynecology;Health;health data;Health Professional;health science research;Health Sciences;Human;improved;indexing;insight;instrument;Integrative Medicine;interdisciplinary approach;Investigation;Leadership;Libraries;literacy;Malignant Neoplasms;manufacture;Maps;Measures;medical specialties;member;Meta-Analysis;Methodology;Methods;next generation;novel;Outcome;Participant;Pathway interactions;Patients;Pattern;Pesticides;Pollution;Population;population health;Population Research;programs;Psychosocial Stress;psychosocial stressors;Public Health;Questionnaires;Recreation;Reporting;Reproductive Biology;Reproductive Health;Reproductive Sciences;Research;Research Design;Research Personnel;Resources;Restaurants;Role;San Francisco;Science;Scientist;Services;social stressor;Societies;socioeconomics;Spanish;Specialist;statistics;stressor;Study models;systematic review;Testing;tool;Training;translational health science;Translational Research;Translations;Universities;Vulnerable Populations;Water

PROJECT_TITLE: Integrative Health Sciences Facility Core


ADMINISTERING_IC: ES

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: MEEKER, JOHN D. (contact)

PROJECT_TERMS: Address;Applications Grants;Area;Career Mobility;Clinical;Collaborations;Communities;community engagement;Conflict of Interest;Core Facility;Creativeness;Data;Data Scientist;Disease;Environmental Exposure;Environmental Health;Epidemiologist;faculty support;Funding;Funding Mechanisms;health determinants;improved;Individual;innovation;insight;Institution;Interdisciplinary Study;Knowledge;Life;medical schools;member;Michigan;Mission;National Institute of Environmental Health Sciences;Pilot Projects;Predisposition;programs;Public Health Schools;Publications;Request for Applications;Research;Research Personnel;Research Project Grants;Research Support;response;Review Committee;Scientist;System;Time;Translational Research;Work

PROJECT_TITLE: Pilot Project Program

STUDY_SECTION: EHS

STUDY_SECTION_NAME: Environmental Health Sciences Review Committee[EHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PI_NAMEs: FUNG, JENNIFER C (contact)

PROJECT_TERMS: Air;Area;Biological;Biological Assay;Biological Models;Biological Monitoring;Biological Process;California;Cells;Chemical Exposure;Chemical Models;Chemicals;Communities;community engagement;consumer product;Core Facility;cost;cost effective;Data Analyses;data integration;Dedications;Defect;Detection;Development;Disease;Ensure;Environment;Environmental Exposure;Environmental Health;Epidemiology;Equipment;Evaluation;Evolution;experimental study;Fostering;Funding;Goals;Growth;Hazardous Waste;Health;Health Professional;high throughput screening;Human;human tissue;in vivo;Individual;innovation;Institution;Investments;Ions;Laboratories;Link;Mass Spectrum Analysis;Measurement;Measures;media use;member;model organism;Monitor;Morphology;Mus;new technology;novel;Organism;Pathway interactions;Peptides;physiologic model;Planet Earth;Poison;Procedures;programs;Proliferating;Proteomics;Reaction;Reproducibility;reproductive;Research;Research Design;Research Personnel;Resources;Sampling;Scientist;screening;Services;Shotguns;skills;small molecule libraries;Soil;Specialist;Specimen;Standardization;Stream;Technical Expertise;Technology;tissue culture;Tissue Sample;tissue/cell culture;Tissues;tool;toxicant;Translations;Water;Xenograft procedure

PROJECT_TITLE: Bioassay Facility Core


PI_NAMEs: CHARLESWORTH, ANNEMARIE  (contact)

PROJECT_TERMS: Address;Advisory Committees;Award;Binding;California;career;Caring;Clinic;Clinical;clinical application;Collaborations;Communication;Communities;community engagement;Complex;Discipline of Nursing;Disease;Education;Education Gap;Educational Curriculum;Educational Materials;Ensure;Environment;Environmental Exposure;Environmental Health;Environmental Medicine;Etiology;Face;Feedback;Foundations;Funding;Future;Goals;Growth;Health;health disparity populations;Health education;health literacy;Health Professional;Health Resources;Healthcare;implementation evaluation;Knowledge;Leadership;Learning;Life;Location;Mainstreaming;Medical Education;medical schools;Medical Students;member;Mentors;Modeling;National Institute of Environmental Health Sciences;Neighborhood Health Center;Nursing Faculty;Patient Education;Patients;Pilot Projects;Positioning Attribute;preservation;prevent;Prevention;Professional Organizations;Professional Practice;programs;Public Health;Reproductive Health;Research;Research Personnel;Resources;Role;San Francisco;Scholars Program;Science;Scientist;skills;Source;Students;tool;Training;Translations;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Pediatric leukemia patients bearing Mixed-lineage leukemia (MLL) gene translocations are associated with dismal prognosis and poor response to standard treatments. This proposal aims to develop novel ENL small- molecule degraders as in vivo chemical probes to target ENL, a promising drug target we recently identified, and test our therapeutic hypothesis that pharmacological degradation of ENL will provide a novel and effective strategy for treating MLL-rearranged leukemias. The proposed research is directly relevant to public health.

PI_NAMEs: JIN, JIAN  (contact);WEN, HONG

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: absorption;Acetylation;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Apoptosis;Biochemical;Biological Assay;Biophysics;cell killing;Cell Membrane Permeability;Cell model;Cell Proliferation;Cells;Chemicals;Childhood Leukemia;Chromatin;Chromosomal translocation;Clinic;Complex;design;Development;Disease;driver mutation;drug candidate;Drug Kinetics;Drug Targeting;effective therapy;efficacy evaluation;ENL Protein;Evolution;Excretory function;Future;Gene Expression;Gene Rearrangement;gene translocation;Growth;Histone Acetylation;Histone H3;histone methyltransferase;Histones;Human;In Vitro;in vivo;Infant;inhibitor;innovation;Knock-out;Lead;leukemia;Leukemic Cell;Ligands;Link;Lysine;Metabolism;Methylation;Methyltransferase;Mixed-Lineage Leukemia;MLL gene;MLLT3 gene;Molecular;mouse model;Nature;novel;novel therapeutic intervention;Oncogenic;Pathogenesis;Pathway interactions;Patients;pharmacologic;Pharmacology;Phenocopy;Prognosis;Proliferating;Property;Protac;protein degradation;prototype;Public Health;Reader;Reporting;Research;response;small molecule;small molecule inhibitor;standard care;Technology;Testing;Therapeutic;therapeutic target;therapeutically effective;Toxic effect;transcriptome;Translating;ubiquitin-protein ligase

PROJECT_TITLE: Development of Novel PROTACs Targeting the ENL YEATS Domain for Treating MLL-rearranged Leukemias

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The molecular regulators of valvular delamination – a critical morphogenetic step of valvulogenesis whose dysfunction underlies a rare tricuspid valve malformation, Ebstein’s Anomaly – remain largely unknown. I will apply an innovative multi-omic approach to identify the intercellular interactions regulating this morphogenetic process and define the gene regulatory networks that drive valvular interstitial cell fate determination. This study will deepen our understanding of valvulogenesis and inform future efforts toward the development of novel regenerative medicine-based therapeutics for congenital and acquired valvulopathies.

PI_NAMEs: MERRIMAN, ALEXANDER FLAHERTY (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Adult;Anatomy;Apical;ATAC-seq;Automobile Driving;Bar Codes;Biological;Biological Assay;Biological Models;Biology;Blood flow;Cardiac;cardiac tissue engineering;career;Cell Communication;Cell Differentiation process;Cell Maturation;Cell Physiology;Cells;Childhood;Chromatin;Clinical;clinical training;Collaborations;Complex;Congenital Heart Defects;Data;Defect;Development;Disease;Dissection;Doctor of Philosophy;Dyes;Ebstein's Anomaly;Electrophysiology (science);Elements;Endothelium;epigenomics;epithelial to mesenchymal transition;Event;Failure;Fellowship;Fostering;Functional disorder;Future;Gene Expression Profile;gene regulatory network;genetic analysis;Genomics;Goals;Heart;Heart Atrium;Heart Transplantation;Heart Valves;high throughput screening;human disease;Human Genetics;human tissue;in vivo Model;Individual;information gathering;innovation;interstitial cell;Lateral;Location;Machine Learning;Maintenance;malformation;Maps;Mediating;Mentorship;Mesenchymal;Mesenchyme;Molecular;Morbidity - disease rate;Morphogenesis;Morphology;mortality;mouse model;mRNA Expression;multiple omics;Mus;Muscle;Myocardial;Myocardium;National Research Service Awards;novel;novel therapeutics;Operative Surgical Procedures;Pathogenesis;patient oriented;Patients;periostin;pharmacologic;Phenotype;Population;Preceptorship;Process;programs;prospective;Prosthesis;Regenerative Medicine;Regulation;Research;Resolution;Right ventricular structure;RNA;Scientist;Secondary to;Secure;Signal Pathway;Signal Transduction;single cell ATAC-seq;single cell genomics;single cell sequencing;single-cell RNA sequencing;Slide;Source;spatiotemporal;stem cell biology;Surgeon;System;Techniques;Testing;Therapeutic;Time;Tissue Sample;tool;Training;transcriptomics;Tricuspid valve structure;Variant;Ventricular

PROJECT_TITLE: Defining the molecular regulators of valvular delamination via multi-omic dissection of Ebstein’s Anomaly


ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The proposed studies will advance our understanding of the molecular mechanisms underlying sex differences as determined by the interaction of cytochrome P450 (CYP)1B1-generated metabolites of estrogen and testosterone and arachidonate-12/15lipoxygenase, and CYP4a generated prohypertensive metabolites in the brain in an experimental model of angiotensin II-induced hypertension and associated pathogenesis. Furthermore, these studies would identify these enzyme systems in the brain as a potential site of action of selective inhibitors for treating hypertension and associated neuroinflammation, vascular dysfunction, and kidney damage in both sexes.

PI_NAMEs: MALIK, KAFAIT U (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: 2-methoxyestradiol;Address;Adenoviruses;Adrenergic Agents;ALOX15 gene;Angiotensin II;Angiotensins;antagonist;Aorta;arachidonate;Arachidonate 15-Lipoxygenase;Arachidonic Acids;Area;Attenuated;Biochemical;Blood Pressure;blood pressure elevation;Blood Vessels;Brain;Clinical;CYP1B1 gene;Cytochrome P450;Data;DNA;Eicosanoids;Enzyme Inhibitor Drugs;Enzymes;Estradiol;Estrogens;Experimental Models;Female;Flow Cytometry;Fluorescence Microscopy;Gonadal Steroid Hormones;GPR31 receptor;GPR75 gene;Histologic;Hydroxyeicosatetraenoic Acids;Hypertension;hypertensive;immune cell infiltrate;inhibitor;Injections;insight;Kidney;LOX gene;male;Measures;Molecular;Mus;neuroinflammation;novel;Orchiectomy;Organ;Ovariectomy;overexpression;Oxidative Stress;paraventricular nucleus;Pathogenesis;Pathologic;Plasma;Production;Prostaglandins;receptor;reconstitution;renal damage;Renal function;sex;Sex Differences;Site;small hairpin RNA;Small Interfering RNA;System;Techniques;Testing;Testosterone;Urine;Vascular Diseases

PROJECT_TITLE: Angiotensins, Prostaglandins and Adrenergic Interactions

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


PI_NAMEs: LAIRD, DIANA J (contact)

PROJECT_TERMS: Address;Area;Award;base;Basic Science;Biomedical Research;California;career;career development;Clinical;Clinical Research;Collaborations;Communities;community engagement;Community Health;Conceptions;Core Facility;Dedications;Development;Ensure;Environmental Health;Epidemiology;epidemiology study;Evaluation;experience;Faculty;Feedback;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;Health;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;Link;member;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Environmental Health Sciences;next generation;novel;Outcome;Pilot Projects;Population;Process;Professional Practice;programs;Reporting;Reproduction;Request for Applications;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;San Francisco;Scientist;Site;skills;success;Time;Translational Research;Translations;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative  Our proposal fundamentally centers around the most critical clinical question in early prostate cancer that is the basis for clinical decision making; namely, can we identify proteomic, imaging, and/or microenvironment features that distinguish those aggressive cancers that will progress to cause harm from benign cancers that can be safely monitored by watchful waiting?

PI_NAMEs: MALLICK, PARAG KUMAR (contact)

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: adverse outcome;angiogenesis;Apoptosis;Benign;Biological;Biological Markers;Biopsy;cancer care;Cancer Etiology;Cancer Patient;candidate marker;CD4 Positive T Lymphocytes;Cell Cycle;cell type;Cells;Cessation of life;Characteristics;Classification;Clinical;clinical decision-making;cohort;convolutional neural network;cost;Data;deep learning;density;Diagnosis;Disease;DNA Sequence Alteration;Environment;Environmental Risk Factor;Epithelium;ethnic diversity;Event;Financial cost;follow-up;Formalin;Genomics;Gleason Grade for Prostate Cancer;Heterogeneity;Histologic;Hypoxia;Image;Imaging Device;Immune;immune cell infiltrate;Immune response;Immunofluorescence Immunologic;improved;In Situ;Indolent;Institution;Link;Lung;Machine Learning;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant neoplasm of prostate;Malignant Neoplasms;men;Methodology;Methods;Molecular;Molecular Analysis;Molecular Evolution;molecular pathology;molecular phenotype;molecular subtypes;Monitor;Morbidity - disease rate;Morphology;Neighborhoods;Neoplasm Metastasis;novel;Paraffin Embedding;Pathology;Pathway interactions;Patient observation;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Physicians;PI3K/AKT;Prevalence;Process;prognostic;prognostication;prostate cancer progression;Prostate-Specific Antigen;Prostatectomy;Prostatic Neoplasms;Proteins;Proteomics;PSA screening;Risk;Role;Screening for Prostate Cancer;Screening procedure;Sensitivity and Specificity;serum PSA;Signal Pathway;Stains;success;System;Techniques;Texture;Tissue Microarray;tool;tumor;tumor metabolism;tumor microenvironment;tumor progression;Uncertainty

PROJECT_TITLE: Pathomic Predictors of Prostate Cancer Progression


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Rare Diseases;Rehabilitation;Stroke

ORG_CITY: PHILADELPHIA

ORG_NAME: ALBERT EINSTEIN HEALTHCARE NETWORK

ORG_STATE: PA

PHR: PROJECT NARRATIVE Apraxia is a common, disabling, but poorly understood impairment observed in several neurological disorders, particularly following a left hemisphere stroke, that selectively affects the ability to perform daily activities such as imitation and tool-use (i.e., praxis). This project aims to identify how two distinct processing mechanisms, supported by different brain regions, both contribute to imitation and tool-use behaviors. This serves as an important step toward developing tailored neurorehabilitation programs that can identify and take advantage of those processes and brain regions that remain intact in patients after stroke.

PI_NAMEs: WONG, AARON L (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Activities of Daily Living;Affect;Apraxia;Area;arm;base;Behavior;Behavior assessment;behavior measurement;behavioral impairment;Behavioral Mechanisms;Brain region;Caregivers;Chronic;Clinical;Cognitive;Communication;Compensation;Complex;Cues;Data;Data Pooling;Dependence;Disabling;Discrimination;Disease;Disparate;Dissociation;Dorsal;Elbow;Environment;Exhibits;Goals;grasp;Hand;Human;Impairment;Individual;Inferior;injury recovery;Instruction;Job Description;kinematics;Learning;Left;Lesion;Letters;Limb structure;Link;Location;Maps;Measures;Modeling;Motion;Motor;motor behavior;Motor Cortex;Movement;Nervous System Disorder;Neuroanatomy;neurological rehabilitation;Neurosciences;novel;Parietal;Pathway interactions;Patients;Perception;Performance;Positioning Attribute;post stroke;Process;Production;programs;Rehabilitation therapy;Research;Rotation;Route;Scientific Inquiry;Sensory;Shoulder;skills;Specific qualifier value;Stroke;stroke patient;stroke recovery;Study models;Symptoms;Tennis;Testing;theories;tool;Training;Transcranial magnetic stimulation;Translating;Visual;Work;Wrist;Writing

PROJECT_TITLE: Investigating a dual-pathway framework for praxis

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This grant proposes several studies to address knowledge gaps and develop strategies to improve the safety of patients and healthcare workers by preventing transmission of pathogens and improving antibiotic use in diverse healthcare settings and patient populations.

PI_NAMEs: COSGROVE, SARA ELIZABETH (contact);ROCK, CLARE

PROJECT_TITLE: RFA-CK20-004: Johns Hopkins Prevention Epicenter: Transdisciplinary Research Approaches to Prevent Healthcare Associated Infections and Antibiotic Resistance (TRAP HAI & AR)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Lung;Pediatric;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to public health because severe lung disease (LD) is an emerging complication of systemic juvenile idiopathic arthritis (SJIA) and macrophage activation syndrome (MAS) has rapidly become the leading cause of death for children with this disorder. The proposed aims will mechanistically define the role of IFNγ as well as IL-1 blockade in an experimental model of lung disease in MAS as well as children with SJIA-LD, informing clinical care and leading to rapid translation of new therapeutic avenues. The project is relevant to NIH’s mission through seeking fundamental knowledge about the nature of systemic cytokine storms, and applying that knowledge to influence established treatment paradigms in SJIA, particularly with regards to the continued use of biologic therapy and risk of SJIA-LD.

PI_NAMEs: SCHULERT, GRANT SANFORD (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Affect;Alveolar Macrophages;Anti-Inflammatory Agents;Arthritis;Automobile Driving;Biological;Biological Assay;Biological Models;Biological Products;Biological Response Modifier Therapy;Biology;biomedical referral center;Bronchoalveolar Lavage Fluid;Cause of Death;Cells;chemokine;Child;Childhood;Chronic;Clinical;clinical care;cohort;Complication;cytokine;cytokine release syndrome;Data;Data Set;Development;Diagnosis;Disease;Etiology;Experimental Models;experimental study;Exposure to;Failure;Flow Cytometry;Functional disorder;Gene Expression;Gene Expression Profile;genetic signature;Goals;human disease;human model;Immune;Immunobiology;in vivo;Incidence;Inflammation;Inflammatory;insight;Interferon Type II;Interferons;Interleukin-1;International;interstitial;Interstitial Lung Diseases;Knowledge;Life;Link;Lung;lung development;Lung Diseases;Macrophage;Macrophage activation syndrome;Mediator;Mission;Modeling;Monoclonal Antibodies;mouse model;Mus;Nature;novel;novel therapeutics;Pathogenesis;Pathway interactions;Patients;Phagocytosis;Pharmaceutical Preparations;Phenotype;Population;prevent;programs;prospective;Public Health;Pulmonary Alveolar Proteinosis;pulmonary function;Pulmonary Inflammation;Pulmonology;Recurrence;Reporting;Research;Resolution;Rheumatology;Risk;Role;Signal Transduction;single-cell RNA sequencing;Structure of parenchyma of lung;synergism;System;systemic juvenile idiopathic arthritis;Systemic Therapy;targeted treatment;Testing;tool;Translations;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Pathogenesis of Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Public Health Relevance Section African Americans living in the inner city disproportionately experience one or more health-related social needs (HRSN) such as housing instability, food insecurity, transportation needs, utility needs, interpersonal safety, and financial strain, which impacts the complex self-management of type 2 diabetes and chronic kidney disease, also known as diabetic kidney disease. The goal of this K23 proposal is to use a convergent parallel mixed methods study design, which uniquely integrates the patients’ lived experiences, to inform the development of a culturally tailored intervention that addresses health-related social needs to improve clinical outcomes, quality of life, and self-care behaviors in African American adults with diabetic kidney disease living in the inner-city. Successful completion of this proposal will provide new evidence on potential targets and components of an intervention that addresses HRSN in general and particularly among African American adults with diabetic kidney disease.

PI_NAMEs: OZIEH, MUKOSO N (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Acceleration;Address;Adult;African American;African American population;barrier to care;Behavior;behavior change;Behavior Therapy;Blood Pressure;career;Chronic Kidney Failure;Clinical;Community Health Aides;Complex;Complications of Diabetes Mellitus;culturally appropriate intervention;Data;Development;Diabetic Nephropathy;dietary adherence;Dimensions;Disease Management;Disease Progression;Effectiveness;Employment;End stage renal failure;exercise adherence;experience;Financial Hardship;food insecurity;Glycosylated hemoglobin A;Goals;health disparity;high risk;housing instability;improved;Individual;inner city;innovation;Intervention;intervention mapping;Intervention Studies;Interview;Knowledge;Life Style;Lipids;Lived experience;Long-Term Effects;medication compliance;Mentored Patient-Oriented Research Career Development Award;Methods;Monitor;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patient Education;Patient-Focused Outcomes;Patients;peer support;Population;Quality of life;Randomized, Controlled Trials;Research Design;Review Literature;Risk;Role;Safety;Sampling;Self Care;Self Management;social adversity;Transportation

PROJECT_TITLE: Mixed-Methods Study of Multidimensional Adversity in Inner-City African American Adults with Chronic Kidney Disease and Type 2 Diabetes Mellitus


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There are marked disparities in type 2 diabetes prevalence among socioeconomically disadvantaged and socially vulnerable populations. Tackling disparities in diabetes incidence requires innovative strategies that address both clinical parameters and underlying social and environmental determinants of health. Incorporating social determinants of health data into risk prediction models to identify those at high risk utilizing data already available in the electronic medical record is a promising avenue to prioritize and tailor local diabetes prevention initiatives to socioeconomically disadvantaged, socially vulnerable individuals, with potential to improve diabetes outcomes and health equity at the population level.

PI_NAMEs: HOWELL, CARRIE R. (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Address;Adult;Affect;Area;Award;barrier to care;Blood Pressure;Body mass index;Cardiometabolic Disease;Characteristics;Cholesterol;Classification;Clinical;cohort;Computerized Medical Record;contextual factors;Coronary Artery Risk Development in Young Adults Study;Data;design;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;disorder prevention;Disparity;disparity reduction;Education;effectiveness evaluation;Enrollment;Environment;Ethnic Origin;Exercise;experience;Focus Groups;Food;Future;Glucose;Goals;Health;health data;health determinants;health disparity;health equity;Health Food;Health Personnel;Health system;high risk;high risk population;improved;Incidence;Income;Individual;individualized prevention;innovation;Insurance Coverage;intersectionality;Intervention;Interview;Investments;K-Series Research Career Programs;Life Style Modification;Longitudinal cohort;low socioeconomic status;Measurement;Mentors;Methods;Modeling;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcome Measure;Patients;Pharmaceutical Preparations;physical inactivity;Population;population based;Prediabetes syndrome;Prevalence;Prevention;Prevention approach;progression risk;Public Health;Qualitative Methods;Race;Reasons for Geographic And Racial Differences in Stroke;recruit;Research;Research Project Grants;Resources;Risk;risk prediction;risk prediction model;risk stratification;rurality;sex;skills;social;social factors;social health determinants;social vulnerability;Societies;socioeconomic disadvantage;Socioeconomic Status;Staging;statistics;Structure;Time;Training;Validation;Variant;Vulnerable Populations

PROJECT_TITLE: Harnessing social determinant of health data to identify and engage high risk, socially vulnerable populations for diabetes prevention


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: ENCINITAS

ORG_NAME: ANTLIA BIOSCIENCE INC

PHR: NARRATIVE  High blood pressure affects one-third of US adults, yet up to 20% of patients being treated for high blood pressure do not respond to any drugs. Antlia Biosciences is developing a long-acting analog of the human hormone brain natriuretic peptide, hBNP, to significantly lower blood pressure in this patient population via a 1x monthly (or longer) subcutaneous (SC) injection. If successful, this work will lead to clinical testing and ultimately commercialization of a drug for resistant hypertension and other chronic cardiovascular indications that patients can dose 1x monthly SC, with follow-up formulations that would be dosed at up to 3-month intervals.

PI_NAMEs: JOHNSON, BRIAN LAURENCE (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Adverse event;Affect;Aging;aging population;Agonist;Alanine;Amino Acids;analog;Angiotensins;Animals;Anti-Hypertensive Agents;assay development;Biological Assay;Biological Sciences;Blood;Blood Pressure;Blood Pressure Monitors;blood pressure reduction;Bolus Infusion;Brain natriuretic peptide;Canis familiaris;Cardiovascular system;Cells;Cessation of life;cGMP production;Chronic;Clinical;clinical candidate;commercialization;Congestive Heart Failure;Cyclic GMP;Data;design;dosage;Dose;Drug Kinetics;Drug resistance;effective therapy;Effectiveness;Electrocardiogram;Endothelium;Enzymes;Excretory function;extend lifespan;FDA approved;Female;first-in-human;follow-up;Formulation;Frequencies;Future;GMP lots;Goals;Half-Life;Healthcare;Heart;Heart failure;Heart Rate;Heart Ventricle;Hormones;hospital readmission;Hour;Human;Hypertension;hypertension treatment;hypertensive;Infusion procedures;Injections;innovation;Intravenous Bolus;Intravenous infusion procedures;Kidney;male;manufacture;Manufactured Materials;Manufacturer;manufacturing process development;manufacturing scale-up;Measures;Mediating;Methods;Monitor;Natrecor;No-Observed-Adverse-Effect Level;novel;patient population;Patients;peptide analog;Peptides;Permeability;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase Ib Trial;Plasma;Preparation;Prevalence;Production;Proline;Recovery;Renin;research clinical testing;Research Design;Resistance;Resistant Hypertension;response;Safety;safety study;safety testing;Sales;Schedule;Serine;sex;side effect;Sodium Chloride;subcutaneous;Subcutaneous Injections;Subgroup;System;Therapeutic;therapy resistant;Time;Toxic effect;Toxicokinetics;Toxicology;Transfection;Urine;Validation;Vasodilation;Water;Work

PROJECT_TITLE: A novel long-acting conjugate of the vasodilative hormone, human brain natriuretic peptide (hBNP), to treat resistant hypertension

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Diabetes;Wound Healing and Care

ORG_CITY: Tucson

ORG_NAME: CERIA THERAPEUTICS, INC.

ORG_STATE: AZ

PHR: NARRATIVE  Non-healing wounds in diabetic patients represent a significant clinical problem and effective treatments are lacking; only one therapy is currently approved by the FDA, but exhibits questionable efficacy and is less effective than our product, CTX-001. CTX-001 has been formulated as an injectable gel to target two critical events that are dysregulated in diabetic wounds: chronic inflammation and oxidative stress. Based on strong preliminary data and our pre-IND meeting with the FDA, the ultimate goal of this Direct to Phase II proposal by Ceria is to complete cGMP-grade manufacturing and characterization of CTX-001 drug product, confirm efficacy in two relevant models of diabetic mice and pigs, and perform GLP-compliant toxicity studies to fulfill IND requirements.

PI_NAMEs: JACKSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Acute;acute toxicity;American;Amputation;Animals;Anti-Inflammatory Agents;antioxidant therapy;Becaplermin;Biological Assay;Cavia;cerium oxide nanoparticle;Chromosome abnormality;Chronic;Clinical;Clinical Trials;Collaborations;Complications of Diabetes Mellitus;cost;Cyclophosphamide;Data;Debridement;Dermal;design;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Dose;Drug Kinetics;effective therapy;efficacy study;Etiology;Event;Exhibits;experimental study;Family suidae;FDA approved;first-in-human;Formulation;Frequencies;Funding;Gel;genotoxicity;Goals;Good Manufacturing Process;healing;Human;Impaired healing;Impaired wound healing;Impairment;improved;In Vitro;Inductively Coupled Plasma Mass Spectrometry;Infection;Infection Control;Inflammation;Inflammatory Response;Injectable;Intervention;intradermal injection;Intravenous;intravenous administration;irritation;Lead;Legal patent;limb amputation;Limb structure;Lower Extremity;manufacture;Measures;Methods;MicroRNAs;Miniature Swine;Modeling;Mus;mutation assay;non-diabetic;non-healing wounds;novel;novel therapeutics;Nuclear;Oxidative Stress;Particle Size;Pathogenesis;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacotherapy;Phase;Phase I Clinical Trials;Platelet-Derived Growth Factor;Population;porcine model;Positioning Attribute;pre-Investigational New Drug meeting;preclinical efficacy;Preparation;pressure;Property;Protocols documentation;Rattus;Reactive Oxygen Species;Recombinants;Recommendation;Role;Route;Running;safety study;scale up;Services;side effect;Small Business Innovation Research Grant;Sprague-Dawley Rats;Streptozocin;Testing;Therapeutic;Thick;Topical application;Toxic effect;Toxicokinetics;Toxicology;Ulcer;wound;wound care;wound environment;wound healing;Wound Infection

PROJECT_TITLE: A Novel Anti-inflammatoryand Anti-oxidant Therapy for Treating Non-healing Diabetic Foot Ulcers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Bethesda

ORG_NAME: INSILICA, LLC

PHR: The Phase I objective is to design, develop, and demonstrate feasibility of srvc-EHSR ("Sysrev version control - environmental and health systematic reviews"), a modular, cloud-based, remote-installation-capable, platform which allows researchers to build customizable literature review workflows for environmental and health- related risk assessments. While several established platforms for systematic literature review exist, they lack interoperability, are not fit-for-purpose for risk assessment, and their complex codebase makes it too unwieldy to integrate new features to adapt systematic review methodologies for specific use-cases. Therefore, srvc- EHSR will increase the efficiency of literature reviews, make literature reviews more applicable to risk assessments, produce standardized data for research consumption, inform new and more powerful in silico models, decrease the scientific community's reliance on animal testing, and promote safe chemical use in consumer and industrial products and formulations.

PI_NAMEs: LUECHTEFELD, THOMAS  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Academia;Adoption;Agriculture;Agrochemicals;Animal Testing;Architecture;base;Chemical Actions;Chemicals;cloud based;Code;commercialization;Communities;Complex;Computer software;consumer product;Consumption;Cosmetics;cost;Data;Data Aggregation;data curation;data standards;Data Store;design;Development;Ensure;Environmental Health;Evaluation;Expenditure;Food Additives;Formulation;Government;Health;health data;Home;Hour;in silico;Individual;Industrial Product;Industrialization;Industry;innovation;interoperability;Intervention;large language model;Link;Literature;Machine Learning;machine learning model;Manuals;Maps;Marketing;Medical Device;Methodology;Modeling;novel;Pharmacologic Substance;Phase;phase 1 study;Poison;Process;prototype;Reporting;Research;Research Personnel;Review Literature;Risk Assessment;Safety;Series;Site;Source;Standardization;success;systematic review;Testing;Time;tool;Toxicology;usability

PROJECT_TITLE: srvc-EHSR: Sysrev Version Control - Environmental and Health Related Systematic Reviews

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (14)]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE Duke will serve as a UH3 HEAL Research Site and conduct a “Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (SCI).” This project will provide strong evidence for an FDA-approved, non-opiate therapy to specifically improve pain associated with SCI as well as potentially also impact motor, sensory and bladder function. The overall goal of this intervention is to improve pain and quality of life of patients with SCI.

PI_NAMEs: LAD, SHIVANAND P (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Affect;American;Anatomy;Area;arm;Bladder;Bladder Control;Blinded;chronic neuropathic pain;chronic pain;Clinical;clinical application;Cognitive;Control Groups;conus medullaris;Credentialing;Data Analyses;Devices;Dimensions;Direct Costs;Distal;Double-Blind Method;Dropout;Early Intervention;Economics;Electric Stimulation;Elements;Emotional;Equipment and supply inventories;FDA approved;Goals;group intervention;Health;Health Care Costs;health related quality of life;Helping to End Addiction Long-term;Home;Impairment;impression;improved;Individual;Information Dissemination;Information Systems;innovation;Institutional Review Boards;Intervention;Lead;Lesion;life time cost;Limb structure;Longterm Follow-up;Lower Extremity;Measurement;Measures;Medical;Modeling;Motor;motor recovery;Muscle;neurorestoration;Neurostimulation procedures of spinal cord tissue;Numeric Rating Scale;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;Pain intensity;Pain management;pain outcome;pain relief;painful neuropathy;Patient Outcomes Assessments;Patient Recruitments;Patients;Perceived quality of life;Persistent pain;Persons;physical conditioning;Physical Function;Physical therapy;placebo group;Population;primary outcome;Procedures;prospective;Provider;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Reporting;Research;Sample Size;Sampling;secondary outcome;Secondary to;Sensory;severe injury;Severities;Site;Sleep;Societies;spasticity;Spinal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spinal Injuries;standard of care;Surveys;Testing;Therapeutic;Thoracic spinal cord structure;Training;United States;Upper Extremity;Urodynamics

PROJECT_TITLE: A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (SCI)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BLOOMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative: The maintenance of proteostasis is crucial for resistance to disease and healthy aging. One of the key elements of proteostasis is protein degradation. This project aims to improve our understanding of how ubiquitin, protein substrates and the proteasome interact so as to degrade proteins.

PI_NAMEs: CLEMMER, DAVID E. (contact);MATOUSCHEK, ANDREAS

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affinity;aging related disease;Analytical Chemistry;Attenuated;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Cell Physiology;Cells;Cellular biology;Chemicals;Collaborations;Complex;crosslink;Crosslinker;Data;data acquisition;Data Analyses;defined contribution;detection sensitivity;Development;Discipline;Disease Resistance;Elements;experience;experimental study;Genetic;genetic regulatory protein;Geometry;healthy aging;Hematologic Neoplasms;Immune response;improved;In Vitro;Indiana;instrumentation;Ions;Kinetics;Ligands;Maintenance;Mass Spectrum Analysis;Methodology;Methods;Modification;Molecular;Molecular Biology;multicatalytic endopeptidase complex;Mutagenesis;Neurodegenerative Disorders;novel;Peptides;Physiological;polypeptide;Polyubiquitin;Process;Proteasome Binding;Proteasome Inhibitor;protein degradation;Protein Engineering;Proteins;Proteome;Proteomics;proteostasis;purge;Quality Control;receptor;Reporting;Research;Research Personnel;Role;Signal Transduction;Site;Specificity;Structure;Substrate Interaction;System;Testing;Texas;therapeutic target;Ubiquitin;Ubiquitination;Universities;yeast genetics;Yeasts

PROJECT_TITLE: Characterizing proteasome-substrate interactions by mass spectrometry proteomics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE A novel combination therapy that targets common genetic alterations in ovarian cancer will be tested for efficacy in promoting tumor regression and preventing relapse in ovarian cancer. Proposed studies will use novel patient-derived xenograft models and tumor samples from patients in the first clinical trial in ovarian cancer testing this therapy.

PI_NAMEs: SIMPKINS, FIONA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;ATR gene;Behavior;Bioinformatics;biomarker identification;brca gene;cancer cell;cancer genetics;Cancer Patient;cancer therapy;Candidate Disease Gene;CCNE1 gene;Cell Cycle Checkpoint;Cessation of life;Characteristics;Chemoresistance;Clinic;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Combined Modality Therapy;CRISPR/Cas technology;Data;Defect;Dependence;DNA Double Strand Break;DNA replication fork;DNA sequencing;Double Strand Break Repair;Drug resistance;effectiveness testing;efficacy evaluation;efficacy testing;experimental study;Frequencies;Future;Genes;Genetic;Genome Stability;Genomics;genotoxicity;homologous recombination;homologous recombination deficiency;Human;improved;In Vitro;inhibitor;innovation;insight;knock-down;Lead;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Modeling;Monitor;Mus;Mutation;novel;novel therapeutics;overexpression;patient derived xenograft model;patient population;patient stratification;Patients;Phosphotransferases;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Positioning Attribute;pre-clinical;preclinical trial;predictive marker;prevent;Primary Neoplasm;Proteins;Proteomics;Recurrence;Relapse;relapse prevention;Reporting;Resistance;resistance mechanism;response;response biomarker;Role;Sampling;Serous;synergism;targeted treatment;Testing;Therapeutic;TP53 gene;transcriptome;transcriptome sequencing;transgene expression;treatment optimization;treatment strategy;tumor;Tumor Promotion;Tumor Suppression;Validation

PROJECT_TITLE: A novel more effective genotoxic therapy for ovarian cancer


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Genetics;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Marfan aortic root aneurysm leads to early dissection or rupture and reduced life expectancy, thus constituting a major health crisis. While prophylactic invasive aortic root surgical replacement can be performed, drug development has been absent since Marfan aneurysm pathophysiology remains unsolved. Our research aims to study molecular and cellular pathways leading to aneurysm formation so that mechanistic-based drug therapies can be discovered.

PI_NAMEs: FISCHBEIN, MICHAEL PETER (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Age;Androgens;Aneurysm;Aorta;Aortic Aneurysm;Automobile Driving;Basic Science;Biological Process;Biomechanics;Cause of Death;Cell Lineage;Cell model;Cells;Chemosensitization;Clinical;Collagen;Connective Tissue Diseases;Deposition;design;Development;Disease;Dissection;drug development;drug discovery;Embryo;experimental study;Extracellular Matrix;FBN1;Functional disorder;Funding;Future;Genes;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Health;Heart;Human;In Vitro;in vivo;induced pluripotent stem cell;Inherited;innovation;Learning;Life Expectancy;male;mannose receptor;Marfan Syndrome;Matrix Metalloproteinases;mechanical properties;Mediating;Medical;MicroRNAs;Modeling;Molecular;Motility;mouse model;Mus;Muscle Contraction;Mutation;NADP;Neural Crest;new therapeutic target;novel;Operative Surgical Procedures;paracrine;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Play;pluripotent stem cell differentiation;Population;Production;Property;prophylactic;Proteolysis;Proteomics;Reactive Oxygen Species;Regimen;Reporting;Research;response;Role;Rupture;scaffold;Severity of illness;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;stem cell model;targeted treatment;transcriptomics;Transforming Growth Factor beta;Transgenic Mice;Translating;Translations;treatment strategy;Vascular Smooth Muscle;Work

PROJECT_TITLE: Marfan Aortic Embryologic Origin Influences Aneurysm Formation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: TAMPA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Vascular inflammation plays a central role in a variety of cardiopulmonary diseases and organ injuries involving the brain, nerves, kidney, gut and placenta. Tremendous gaps of knowledge exist with regard to the cellular and molecular basis of inflammatory injury and its related organ-based pathophysiology, contributing to the hampered development of effective diagnostics and therapeutics. This program recruits a collaborative team of nationally recognized experts in inflammation research who will provide comprehensive training of our next generation of scientists in understanding and solving the complex problems beyond the scope of individual laboratories.

PI_NAMEs: YUAN, SARAH Y (contact)

PROJECT_TITLE: Training in Research on Vascular Inflammation and Injury

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative: Immune checkpoint blockade (ICB) has become an important therapeutic modality across a wide range of cancers, including breast cancer, that typically target inhibitory networks that cancerous cells use to negatively regulate a patient’s immune response. Here we will investigate an inhibitory network in the tumor microenvironment involving constitutively elevated phosphatidylserine (PS), engagement of Mertk receptors on infiltrating macrophages, and subversion of host anti-tumor immunity. We attempt to demonstrate that the PS- >Mertk->PD-L1 axis presents a vulnerability in cancer that can be mechanistically evaluated and therapeutically exploited.

PI_NAMEs: BIRGE, RAYMOND B. (contact);KOTENKO, SERGEI V

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Abbreviations;Address;Advanced Malignant Neoplasm;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-tumor immune response;Antigens;Apoptotic;Archives;AREG gene;Autoimmunity;Binding Proteins;Biology;Breast Cancer Model;cancer type;Cancerous;Caspase;Cells;Chronic;Clinical;Clinical Trials;Cross Presentation;experimental study;Family;FDA approved;Future;Gene Expression Profile;Genes;Growth;Human;human model;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune Tolerance;immunogenicity;Immunooncology;in vivo;Infiltration;Inflammation;Investigation;ipilimumab;Ligands;Lipids;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Modality;Modeling;Monoclonal Antibodies;mouse model;Mus;Myelogenous;Neoplasm Metastasis;neutralizing monoclonal antibodies;novel;Organism;Outcome;Pathway interactions;Patients;phosphatidylserine receptor;Phosphatidylserines;Physiological;pre-clinical;prevent;programmed cell death ligand 1;Proteins;PTGS2 gene;receptor;Receptor Protein-Tyrosine Kinases;Resolution;Role;Series;Signal Transduction;Solid;targeted treatment;Testing;Therapeutic;Tissues;triple-negative invasive breast carcinoma;Tumor Escape;Tumor Immunity;tumor microenvironment;tumor progression;Tumorigenicity;Validation;Vitamin K

PROJECT_TITLE: Targeting a phosphatidylserine/TAM receptor/PD-L1 axis as a vulnerability in cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: The purpose of NE-CAT is to provide the biomedical community with access to state-of-the- art facilities for macromolecular crystallography. NE-CAT will enhance our ability to visualize the three-dimensional structures of biological macromolecules. These structures allow us to better understand basic biological systems, often resulting in the identification of new pharmaceutical targets and aiding in the development of new pharmaceutical agents. 1

PI_NAMEs: ANDO, NOZOMI ;FROMME, J CHRISTOPHER ;MURPHY, FRANK V (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: 20 year old;Advisory Committees;Aging;Area;Automatic Data Processing;beamline;Biological;Biological Process;biological systems;Biomedical Research;Characteristics;Communities;Computer software;computerized data processing;Crystallography;Data Analyses;Data Collection;data structure;Dedications;design;detector;Development;Education and Outreach;Educational workshop;Ensure;experience;Funding;Goals;Grouping;Healthcare;improved;Individual;Infrastructure;Institution;Logistics;macromolecule;Mainstreaming;Maintenance;Manuscripts;meetings;member;Modification;operation;Optics;outreach;outreach program;Paper;Persons;Pharmacologic Substance;Photons;Productivity;Professional Organizations;programs;Publications;Publishing;Recruitment Activity;repaired;Research;Research Personnel;Research Project Grants;Resources;Robotics;Roentgen Rays;Running;Sampling;Schedule;Site;Source;Structure;Synchrotrons;System;Techniques;Technology;three dimensional structure;three-dimensional visualization;Time;Training;Training Activity;Training Programs;United States National Institutes of Health;Universities;web based interface;web site;Work

PROJECT_TITLE: NE-CAT: A Resource for Advanced Macromolecular Crystallography


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Loss of functional cardiomyocytes by apoptotic and/or necrotic cell death is an underlying cause of cardiac ischemic injury and pathological remodeling. This proposal investigates the novel role of the deubiquitinase CYLD as a key regulator of cardiac ischemic injury and remodeling by targeting multiple cell death pathways, aiming to develop new anti-cell death strategies for ischemic heart disease.

PI_NAMEs: LIU, QINGHANG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Antioxidants;Apoptosis;Apoptotic;Attenuated;autosome;Benign;Cardiac;Cardiac Myocytes;cardioprotection;Cell Death;Cell Death Process;Cell Death Signaling Process;Cell Physiology;Cessation of life;Complex;Data;Disease;functional loss;gain of function;Genetic;Goals;Heart;Heart Diseases;Heart failure;in vivo;Inhibition of Apoptosis;ischemic injury;Knock-out;Link;loss of function;Lysine;Mediating;Mitochondria;Molecular;Molecular Target;mouse model;Mus;Mutation;Myocardial;Myocardial Ischemia;Necrosis;Necrosis Induction;new therapeutic target;novel;overexpression;Oxidative Stress Induction;Pathogenesis;Pathologic;Pathway interactions;Phosphotransferases;Physiological;Pilot Projects;Play;Polyubiquitin;Polyubiquitination;prevent;Process;protein transport;Proto-Oncogene Proteins c-akt;receptor;Regulation;Role;Signal Transduction;Signaling Protein;Skin Neoplasms;small hairpin RNA;Testing;Therapeutic;therapeutic target;TNF receptor-associated factor 2;Transgenic Mice;Transgenic Model;Tumor Suppressor Proteins;ubiquitin isopeptidase;Ubiquitination;vector

PROJECT_TITLE: The Deubiquitinase CYLD Controls Multiple Cell Death Pathways in the Heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


PI_NAMEs: EALICK, STEVEN E (contact)

PROJECT_TERMS: 20 year old;Administrator;Advisory Committees;Arts;Automatic Data Processing;beamline;Biohazardous Substance;Biology;Chemicals;Chemistry;Collection;college;Computer software;Crystallography;Data;Data Analyses;Data Collection;data structure;Department of Energy;Deposition;Development;Ensure;experience;Funding Agency;Goals;Human Resources;improved;Individual;Infrastructure;Laboratories;Maintenance;Measures;meetings;Monitor;operation;outreach;payment;Persons;Photons;Procedures;Productivity;programs;Protocols documentation;Publications;recruit;Reporting;Resources;Roentgen Rays;Running;Safety;Schedule;Scheduling and Staffing;Science;Scientist;Services;Site;Source;Structure;Synchrotrons;Time;time use;Training;Travel;Universities;web site

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-P]


PI_NAMEs: MURPHY, FRANK V (contact)

PROJECT_TERMS: Adopted;Automatic Data Processing;base;beamline;Collaborations;Communication;Communities;Computer software;computerized data processing;Crystallography;Data;Data Analyses;Data Collection;design;Education and Outreach;Educational Status;Educational workshop;experience;Felis catus;Goals;Grant;Human Resources;Instruction;interest;Internet;Manuals;Methodology;Methods;Monitor;operation;outreach;Pathology;Persons;Postdoctoral Fellow;Preparation;Procedures;Process;Program Effectiveness;prospective;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;Site;Structure;System;Techniques;Technology;Time;tool;Training;Training Activity;Training Programs;Update;videoconference;Visit;web site;webinar;Work

PROJECT_TITLE: User Training and Outreach


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

PI_NAMEs: CAPEL, MALCOLM S. (contact)

PROJECT_TERMS: 20 year old;Aging;Area;Automatic Data Processing;beamline;Biological Assay;Cells;cluster computing;Communities;computer cluster;computer data analysis;Computer software;computerized data processing;Crystallography;Data;data acquisition;Data Analyses;Data Collection;data reduction;Data Storage and Retrieval;detector;Development;Education and Outreach;falls;flexibility;Funding;Goals;improved;Infrastructure;Institution;instrumentation;Maintenance;Methodology;Methods;Modification;Molecular;Motion;Network Infrastructure;operation;Optics;Pathologic;Performance;Phase;Positioning Attribute;programs;rapid technique;Resolution;Resource Development;Resources;Roentgen Rays;Running;Sampling;Scanning;Schedule;Scientist;screening;Site;Speed;Synchrotrons;System;Techniques;Temperature;Training;two-dimensional;United States National Institutes of Health;Vacuum;Vacuum Pumps

PROJECT_TITLE: MX Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Public Health Relevance/Project Narrative Understanding how blood cells are produced is fundamentally important to human health. We applied genetic studies in humans to identify a new cellular enzyme associated with increased platelet counts, and now propose to further characterize how metabolic function(s) involving the enzyme and its cellular pathway components affect human platelet production and erythrocyte development. This direction of research highlights its importance for blood cell development, most prominent in situations of aging or stress. During the grant period, we propose to complete more detailed biochemical and genetic studies to further study its mechanism of action. Animal models will be used for sophisticated mechanistic studies; comprehensive studies in mice will also provide novel insights into the mechanism(s) of stress hematopoiesis, relevant to human inflammatory conditions and/or patients receiving chemotherapy. Initial goals of characterizing novel chemical inhibitors based on our sophisticated structural models, are predicted to provide important pre-clinical data supporting more future drug development aimed at increasing human platelet counts. All the work proposed in this application builds on studies in humans with significant impact on translational studies designed to increase our understanding of metabolic regulation of blood cell development.

PI_NAMEs: BAHOU, WADIE F (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Address;Advanced Development;Affect;Aging;Anemia;Animal Model;Animals;Applications Grants;Applied Genetics;Basic Science;Bilirubin;Biliverdin reductase;Biliverdine;Biochemical;Biochemistry;Bioenergetics;Blood Cells;Blood Platelets;Buffers;Catabolism;Cell Aging;Cell Line;Cell model;Cells;Cellular Metabolic Process;cellular targeting;Chemicals;Chemistry;chemotherapy;Clinical;cohort;Collaborations;Computational Biology;computer studies;Coupling;Cues;Cytoprotection;Data;Defect;design;Detection;Development;Disease;drug development;Enzymes;Equilibrium;Erythrocytes;Erythroid;Erythropoiesis;Evaluation;experimental study;Funding;Future;Genetic;Genetic study;Goals;Grant;Health;Hematopathology;Hematopoiesis;Hematopoietic;Heme;Homologous Gene;Human;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Inflammatory;inhibitor;insight;Isomerism;Joints;Knock-out;Lead;Link;Lipid Peroxidation;Manuscripts;Megakaryocytes;Metabolic;Metabolic Pathway;Metabolism;Methodology;Modeling;Molecular;mouse model;Mus;Neonatal;novel;oxidant stress;Oxidation-Reduction;Oxidoreductase;Oxygenases;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Platelet Count measurement;Population;pre-clinical;Production;progenitor;Proteins;public health relevance;Reaction;Reactive Oxygen Species;Reagent;Regulation;Research;Research Design;Role;Signal Transduction;stem cells;Stress;structural biology;Structural Models;Tetrapyrroles;Thrombopoiesis;translational study;Validation;Work

PROJECT_TITLE: Molecular characterization of biliverdin IXbeta reductase

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: The objective of this research is to develop, user-test, and pilot a novel behavioral economics mobile health digital tool to improve adherence to non-pharmacologic strategies for behavioral and psychological symptoms of dementia. The intervention will target family care partners of people living with dementia, and results will inform longer-term strategies for reducing behavioral and psychological symptoms of dementia and limiting burden in primary care partners who reside with people living with dementia.

PI_NAMEs: BELLI, HAYLEY MICHELLE (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Alzheimer's Disease;Alzheimer's disease related dementia;American;Antipsychotic Agents;Applications Grants;Area;arm;behavior test;Behavioral;behavioral economics;Behavioral Symptoms;Caring;Chronic;Chronic Disease;Clinical;Collaborations;common symptom;communication device;Data;Degenerative Disorder;Dementia;dementia care;design;Development;diabetes management;digital;digital health;digital tool;Discipline;Disease Management;Drug Prescriptions;Economics;Educational workshop;Electronic Health Record;electronic patient reported outcomes;Emotional;evidence base;experience;Face;falls;Family;Funding;Geriatrics;Goals;Guidelines;Guilt;Health;health care settings;Health system;Health Technology;Healthcare;Human;human old age (65+);Impaired cognition;implementation science;improved;Influenza vaccination;innovation;insight;Intervention;Interview;Measures;Mental Depression;Mentors;Mentorship;mHealth;mhealth interventions;mortality;Nature;New York;Nonpharmacologic Therapy;novel;Outcome;Outcome Study;patient population;Peer Review;Persons;Pharmaceutical Preparations;Pilot Projects;pilot test;Pragmatic clinical trial;Primary Care;primary outcome;prototype;psychologic;psychological symptom;Psychology;Publications;Recording of previous events;recruit;Research;Research Methodology;Research Personnel;Resources;Review Literature;Risk;Role;Screening for cancer;secondary outcome;Sedation procedure;skills;Social Workers;Societies;sociodemographics;Stress;Stroke;Structure;symposium;Tablet Computer;Technology;Telephone;Telephone Interviews;Testing;Text Messaging;Thinking;tool;Training;Training Programs;United States National Institutes of Health;Universities;Visit;wearable device;Work

PROJECT_TITLE: Development and pilot testing of a behavioral economics mobile health digital tool to improve adherence to non-pharmacologic strategies for behavioral and psychological symptoms of dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative Inherited retinal degenerations are important causes of blindness. The goals of the proposed research are to investigate how mutations in a class of genes that encode RNA splicing factors cause retinal degeneration, and to work toward developing genetic therapies for these disorders.

PI_NAMEs: PIERCE, ERIC A (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Affect;Alternative Splicing;Amyotrophic Lateral Sclerosis;Atrophic;Biological Models;Blindness;Cells;Complex;CRISPR/Cas technology;Data;Data Analyses;Defect;differential expression;Disease;Down-Regulation;Event;Functional disorder;Funding;Gene Activation;Gene Expression;gene therapy;Genes;genetic risk factor;Genome;Goals;Human;human induced pluripotent stem cells;improved;in vivo;induced pluripotent stem cell;inherited retinal degeneration;Introns;knock-down;Lead;Messenger RNA;Methods;Molecular;molecular phenotype;Motor;mouse model;mRNA Precursor;Mus;mutant;Mutant Strains Mice;Mutation;Neurodegenerative Disorders;Nonsense-Mediated Decay;Pathogenesis;Phenotype;Progress Reports;Protein Isoforms;Proteins;Research;Retina;Retinal Degeneration;Ribonucleoproteins;RNA;RNA analysis;RNA Processing;RNA Splicing;Rodent;Sampling;screening;Small Nuclear Ribonucleoproteins;Spinal;Spliced Genes;Spliceosomes;Structure;Testing;Therapeutic Uses;therapy development;Tissue-Specific Gene Expression;Tissues;Transcript;Transcription Factor AP-1;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: The Pathogenesis of RNA Splicing Factor Associated Retinal Degeneration


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Xanthine oxidase (XO) activity is significantly increased in a number of vascular diseases including hypertension, sepsis, and sickle cell disease as well as a substantive contributor to poor outcomes allied to cardiovascular surgery and transplantation. Associated with an elevation in XO activity is circulating heme. This grant will test if XO has protective, rather than a deleterious, role in vascular protection through its ability to degrade heme from XO-derived reactive oxygen species. Completion of this study will fill a major gap in our understanding XO’s ability to regulate intravascular heme and may lead to therapeutic strategies to improve cardiovascular health.

PI_NAMEs: KELLEY, ERIC EUGENE;STRAUB, ADAM CARL (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acceleration;Acute;Address;Allopurinol;Ally;Binding;Biochemical;Biological;Biological Assay;Blood Vessels;Cardiopulmonary Bypass;cardiovascular health;Cardiovascular Surgical Procedures;cardiovascular transplantation;Cell Count;chelation;Circulation;Clinical;clinically significant;comparison control;coping;Data;Disease;Effectiveness;Endothelial Cells;Endothelium;Enzymes;Equilibrium;Erythrocytes;exhaust;febuxostat;gain of function;Generations;Globin;Glycosaminoglycans;Grant;Heme;heme oxygenase-1;Hemin;Hemoglobin;Hemolysis;Hemopexin;Hepatic;Hepatocyte;Human;Hydrogen Peroxide;Hypertension;Hypoxanthines;Iatrogenesis;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;Iron;Iron Chelating Agents;Iron Chelation;Kinetics;Knowledge;Link;Literature;Liver;Mediating;Modeling;mouse model;Mus;novel;Operative Surgical Procedures;Organ;Organ failure;Outcome;overexpression;Pathology;Pathway interactions;Patients;Peptide Hydrolases;Permeability;Pharmacology;Physiological;Pilot Projects;Plasma;Plasma Enhancement;Porphyrins;Probability;Process;Production;Proteins;Publishing;Reactive Oxygen Species;Regulation;Reporting;Role;Rupture;Sepsis;Sickle Cell Anemia;Source;Specific qualifier value;Sterility;Stress;Superoxides;Testing;Therapeutic;Uric Acid;valve replacement;Vascular Diseases;vascular injury;Vascular System;vaso-occlusive crisis;ventricular assist device;Xanthine Oxidase;xanthine oxidase inhibitor;Xanthines;XDH gene

PROJECT_TITLE: Role of Xanthine Oxidase in Heme-induced Vascular Dysfunction

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Sleep disorders are highly prevalent in veterans. A 6-fold increase in the diagnosis of sleep disorders was reported at the VA in recent years. Insomnia is associated with increased risk for suicide in veterans, an area of particular interest for VA. Furthermore, other severe neuropsychiatric disorders affecting veterans, such as schizophrenia or dementia, are associated with abnormalities of cortical electrical activity during wakefulness or specific sleep stages. Current attempts to develop treatments are hampered by a poor understanding of the brain circuitry controlling sleep, wakefulness and cortical activity. This research program in mice uses a novel strategy based on developmental biology to identify and characterize the neurons which control brain arousal and sleep in the basal forebrain, a brain area which degenerates in dementia. State-of-the-art genetic techniques will be used to manipulate the activity of these neurons, an essential first step towards correcting abnormalities of sleep-wake behavior and cortical activity in disorders affecting veterans.

PI_NAMEs: BROWN, RITCHIE EDWARD (contact)

PROJECT_TERMS: Ablation;adeno-associated viral vector;Adult;Affect;Area;Arousal;Attention;Auditory;Autopsy;basal forebrain;Behavior;Bilateral;biomarker validation;Brain;brain circuitry;brain control;Calibration;cell type;Cerebral cortex;cholinergic neuron;Clinical Trials;Clozapine;combat;Data;Dementia;density;design;Development;Developmental Biology;Diagnosis;Disease;Ectopic Expression;Electroencephalography;Electrophysiology (science);Embryo;Enterobacteria phage P1 Cre recombinase;Enzymes;experimental study;FOXP2 gene;Future;gamma-Aminobutyric Acid;Gene Modified;gene-editing approach;Genes;Genetic;genetic approach;Genetic Techniques;Glutamates;Goals;Guide RNA;Homeobox;Human;Immunohistochemistry;Injections;innovation;interest;Knock-in Mouse;Lateral;Lesion;Ligands;Link;Location;Maps;Medial;Methods;Military Personnel;Modeling;Motor Activity;Mouse Strains;Mus;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurotransmitters;new therapeutic target;novel;novel strategies;Outcome;Oxides;Parvalbumins;Phenotype;Population;Predisposition;Preoptic Areas;progenitor;programs;Prosencephalon;Proteins;receptor;Reporter;Reporting;Research;response;Rewards;Risk;risk variant;Role;Saline;Schizophrenia;selective expression;sensory stimulus;Sleep;sleep abnormalities;Sleep Disorders;Sleep disturbances;sleep regulation;sleep spindle;Sleep Stages;Sleep Wake Cycle;Sleeplessness;Specific qualifier value;Stains;Subgroup;suicidal risk;targeted treatment;Testing;Time;Toxin;transcription factor;Transcriptional Regulation;Transgenic Mice;translational approach;translational study;Veterans;Viral Vector;Vulnerable Populations;Wakefulness

PROJECT_TITLE: Specification of sleep-wake control neurons in the basal forebrain


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Pediatric

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The proposed studies are relevant to public health because they investigate the mechanisms underlying the biology of the lens, the development of age-related cortical cataracts, and the function of a critical proteins in lens fiber cell biology. Additionally the gene encoding the protein that is the focus of this study (Arvcf) is missing in the chromosomal disorder Velo-cardio-facial/DiGeorge Syndrome. Because this congenital disease includes multiple ocular and lens abnormalities of unknown cause, this study has the potential to elucidate at least part of its etiology. This proposal seeks to understand the function of Arvcf in the lens, how the generation and formation of lens fiber cell morphology contributes to and maintains lens function, and to determine how cellular processes may go awry to disrupt the structure and transparency of the lens, which is a leading cause of blindness world-wide.

PI_NAMEs: PLAGEMAN, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Address;Adherens Junction;Adhesions;Age Months;age related;Animal Model;anti-cancer research;Architecture;ARVCF gene;Attenuated;Bilateral;Binding;Biochemical;Biological Models;Biology;Biomechanics;biophysical properties;Blindness;brain research;Cadherin Domain;Cadherins;Cataract;Cell Adhesion;Cell Culture Techniques;Cell membrane;Cell Physiology;cell type;cell water;Cellular biology;Cellular Morphology;Chromosome Deletion;Complex;Congenital chromosomal disease;Cytoskeletal Modeling;Data;Defect;Development;DiGeorge Syndrome;Disease;Distal;Electron Microscopy;Ensure;Epithelial Cells;Etiology;Event;Excision;experimental study;F-Actin;Face;falls;fiber cell;Generations;Genes;Genetic;Genetic Diseases;genetic regulatory protein;Guanosine Triphosphate Phosphohydrolases;Histologic;Human;inhibitor;Intercellular Junctions;Investigation;Knowledge;Length;lens;Lens Fiber;lens transparency;life span;Link;Maintenance;Malignant Neoplasms;Maps;Measurement;Mediating;member;microscopic imaging;Microscopy;MIP gene;Molecular;Morphology;Mus;mutant;Mutation;N-Cadherin;nanocluster;Nature;Neoplasm Metastasis;Nervous System Disorder;novel;Pathway interactions;Penetrance;Periodicity;Phenotype;preservation;Property;protein complex;Protein Dynamics;Proteins;Proteomics;Public Health;recruit;Refractive Errors;Regulation;rho GTP-Binding Proteins;Schizophrenia;Shapes;Signal Transduction;Structure;superresolution microscopy;Techniques;Testing;translational impact;ultra high resolution;Vision Disorders;Visual impairment;Water

PROJECT_TITLE: Elucidation of Arvcf-dependent mechanisms required for lens function

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative. Proposed research will contribute to fundamental knowledge of how T-cell co-receptors regulate gene expression and T cell function through their influence on RNA maturation. Such knowledge will provide novel opportunities for targeting T-cell co-receptor downstream pathways in a manner that alters T cell responses. Therapeutic strategies to modulate T cell co-receptor downstream pathways have the potential to synergize with therapies targeting T cell co-receptors currently being used to treat cancer and autoimmune diseases.

PI_NAMEs: OLEJNICZAK, SCOTT HENRY (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Affect;Alternative Splicing;Applications Grants;Autoimmune Diseases;Autoimmunity;cancer cell;CD28 gene;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Proliferation;cell type;Cells;Code;Communicable Diseases;Data;Degradation Pathway;discrete time;Elements;engineered T cells;Enzymes;experimental study;functional gain;functional outcomes;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genetically Engineered Mouse;Glucose;Glycolysis;Goals;Human;Immunotherapy;In Vitro;in vivo;insight;Introns;Investigation;Knowledge;Link;Literature;Malignant Neoplasms;Messenger RNA;Metabolic;Modeling;Modernization;Molecular Immunology;mutant;Mutation;neoplastic cell;Normal tissue morphology;novel;Nuclear;Nuclear RNA;Nutrient;Pathway interactions;Patients;PD-1 blockade;Phase;Process;Production;programmed cell death protein 1;programs;Proliferating;Property;Protein Isoforms;Proteins;Pyruvate Kinase;receptor;Receptor Cross-Talk;receptor function;Receptor Signaling;recruit;Regulation;Reporting;Research;response;RNA;RNA Splicing;RNA-Binding Proteins;Role;Shapes;Signal Transduction;Sorting;Surface;synergism;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Transcript;transcriptome;tumor growth;Work

PROJECT_TITLE: Understanding mechanisms and consequences of T cell co-receptor regulated RNA maturation

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative The function of a large number of genes termed long non-coding RNA (lncRNA) is poorly understood. We identified a cardiac specific circadian lncRNA, which affects cardiac remodeling post myocardial infarction by regulating alternative splicing. Understanding the molecular mechanism of this lncRNA will uncover novel gene regulatory pathways in the heart.

PI_NAMEs: ZHANG, LILEI  (contact)

PROJECT_TERMS: Adult;Affect;Age;Alternative Splicing;Binding;biological adaptation to stress;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular Diseases;Categories;Cell Nucleus;Cell Physiology;Chemicals;Chromatin;Chromatin Structure;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Clinical;Data;design;Exhibits;Exons;experimental study;gain of function;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Heart;Heart Diseases;Heart failure;heart function;human induced pluripotent stem cells;In Vitro;in vivo;Incidence;Infarction;Intervention;ischemic cardiomyopathy;Knockout Mice;Mass Spectrum Analysis;Modeling;Molecular;mortality;mouse model;Mus;mutant;Myocardial;Myocardial Infarction;Myocardium;novel;novel strategies;Nuclear;Pathologic;Periodicity;Phase;Poly A;postnatal;promoter;Protein Isoforms;Proteins;Regulation;Regulatory Pathway;response;RNA;RNA Splicing;Role;Series;Site;Spliceosomes;Splicing Regulation Pathway;Stress;Structure;targeted treatment;Techniques;Testing;Therapeutic;Time;Transcript;transcriptome sequencing;Treatment Failure;Untranslated RNA;vector;Work

PROJECT_TITLE: Deciphering the role of a circadian lncRNA in cardiac remodeling

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The discovery of BRAFV600E oncogene in a wide range of human cancers, including >50% of melanomas, has provided opportunities for the development of BRAF and MAPK-targeted cancer therapies, but their benefit has been limited due to tumor-to-tumor and cell-to-cell heterogeneity in the state of BRAF/MAPK dependency. Heterogeneity is regulated by a mixture of genetic, epigenetic, and signaling mechanisms, whose interplay with one another determines the dynamic state of MAPK dependency in tumor cell populations. This study creates a platform to characterize the role of epigenetic factors associated with tumor differentiation state and tissue lineage, with the goal of developing predictive tools to modulate the epigenetic state of BRAF/MAPK dependency in tumor cells and ultimately improving the clinical benefit of MAPK-targeted therapies in patients with BRAF-mutated cancers.

PI_NAMEs: FALLAHI-SICHANI, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: BRAF gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;Cell Differentiation process;cell growth;Cell Line;Cell Survival;cell type;Cells;cellular imaging;Clinical;combinatorial;Computer Models;Data;Dependence;Development;Drug resistance;Drug Tolerance;Epigenetic Process;epigenetic variation;Experimental Genetics;Frequencies;Genetic;Goals;Heterogeneity;histone demethylase;Histones;Human;improved;In Vitro;in vivo;Individual;inhibitor;inhibitor therapy;KDM1A gene;kinase inhibitor;Link;Lysine;Malignant Neoplasms;MAP3K1 gene;Measurement;Measures;Mediating;MEKs;Melanoma;Melanoma Cell;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mutate;Mutation;neoplastic cell;Neural Crest;oncogene addiction;Oncogenes;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pharmaceutical Preparations;Pharmacology;Phenotype;Population;Population Heterogeneity;Post-Translational Protein Processing;predictive tools;prevent;Proteins;Proteomics;Proto-Oncogene Proteins B-raf;Reader;research clinical testing;Resistance;response;Role;Signal Transduction;single cell analysis;small molecule;small molecule inhibitor;Specificity;Statistical Models;System;targeted cancer therapy;targeted treatment;Testing;Tissues;tool;Treatment Efficacy;treatment response;treatment strategy;tumor;tumor xenograft;Undifferentiated;Variant;Work

PROJECT_TITLE: Linking Genetic, Epigenetic and Signaling Mechanisms of Oncogene Addiction

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Organ Transplantation;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Lung transplantation is a life-saving procedure for thousands of people annually, but survival is severely diminished by invasive fungal infections. Aspergillus fumigatus is a common mold that affects one-in-three lung transplant recipients. This proposal seeks to better understand the host-pathogen relationship in lung transplantation, in order to develop new therapeutic approaches for this common infection.

PI_NAMEs: HSU, JOE L (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Address;Affect;Alveolar Macrophages;Alzheimer's Disease;Animals;Aspergillosis;Aspergillus;Aspergillus fumigatus;Atherosclerosis;Biology;Bronchoalveolar Lavage;Cell Culture Techniques;Cell Death;Chronic Obstructive Pulmonary Disease;Clinical;clinically actionable;Cytometry;Defect;design;Discrimination;Effector Cell;emerging pathogen;experimental study;Exposure to;Flow Cytometry;Fluorescence;Fluorescence-Activated Cell Sorting;Genes;Graft Rejection;Granulocyte-Macrophage Colony-Stimulating Factor;Hemorrhage;Histopathologic Grade;Homeostasis;Homologous Transplantation;Host Defense;Human;Immune;Immunity;improved outcome;In Vitro;in vivo;Infection;Inflammatory;Ingestion;inhibitor;Innate Immune Response;Invaded;Iron;Iron Chelation;Iron Overload;Label;Laboratories;Life;Lipid Peroxides;Lipids;Lung Diseases;Lung Transplantation;Macrophage;Macrophage Colony-Stimulating Factor;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Microscopy;Molds;monocyte;Morbidity - disease rate;mortality;Mus;Mycoses;nanoparticle;neutrophil;novel;novel therapeutic intervention;Oranges;Oxidation-Reduction;Parkinson Disease;pathogen;Pathogenesis;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Phenotype;post-transplant;Procedures;Production;Protease Inhibitor;Reactive Oxygen Species;Reperfusion Injury;Reporter;Reproduction spores;response;Role;Statistical Methods;Techniques;Testing;Time;Tissues;Trachea;Transgenic Mice;transplant model;Transplant Recipients;Transplantation;Viral Pneumonia;Western Blotting

PROJECT_TITLE: A critical role for macrophage ferroptosis in promoting fungal invasion in lung transplant recipients

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE Rheumatoid arthritis (RA) and lupus are two diseases that affect the joints and the kidneys. In both diseases, the immune system goes awry and causes chronic inflammation that damages the tissues. We are determining what drives the abnormal cells and their interactions with one another in order to find new ways to target treatments for RA and lupus.

PI_NAMEs: BRENNER, MICHAEL B. (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Abnormal Cell;Acceleration;Affect;Age;Anatomy;Animal Model;Antibody Formation;Antigenic Specificity;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;B-Lymphocytes;Blood;Cell Communication;cell type;Cells;Chronic;Clinical;Complement;computational pipelines;Data;Development;Disease;Disease Clusterings;experimental study;Family;Fibroblasts;Frustration;Genetic Transcription;Goals;Helper-Inducer T-Lymphocyte;Heterogeneity;high dimensionality;Human;human disease;Image;Image Analysis;imaging approach;imaging platform;Immune;Immune system;Immunology;immunopathology;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Arthritis;insight;interest;Joints;Kidney;Laboratories;Lesion;Leukocytes;Lupus;Lupus Nephritis;Macrophage;Medicine;Methods;monocyte;Mus;Myeloid Cells;Nature;Nephritis;neutrophil;notch protein;NOTCH3 gene;novel;Organ;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Phenotype;Population;Production;programs;Reaction;recruit;Rheumatoid Arthritis;risk variant;Role;Signal Transduction;single cell analysis;single cell technology;single-cell RNA sequencing;Stromal Cells;Synovial Membrane;Synovitis;System;Systemic Lupus Erythematosus;T-Lymphocyte;targeted treatment;Therapeutic;Therapeutic Intervention;Tissues;TNF gene;transcription factor;transcriptome;transcriptome sequencing;Virulence Factors;Work

PROJECT_TITLE: Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

PROJECT_TERMS: Accountability;Achievement;Adherence;Agreement;Cells;Communication;Data;Disputes;Doctor of Philosophy;Ensure;Evaluation;Grant;Immune;Immunology;Institution;Lead;Leadership;meetings;Monitor;Office of Administrative Management;programs;Research;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;success;System;Systemic Lupus Erythematosus;timeline;Tissues


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Hematology;Orphan Drug;Rare Diseases;Sickle Cell Disease

ORG_CITY: PHILADELPHIA

PHR: PROJECT NARRATIVE  Although significant progress has been made in understanding the regulation of fetal hemoglobin (HbF) in the treatment of sickle cell disease, very few of these findings have been developed into approved medications that effectively increase HbF levels. I have recently identified a novel regulator of HbF, the protein phosphatase PP6C; this project proposes to study signaling pathways important for PP6C-mediated HbF regulation in healthy individuals and in those with sickle cell disease. Results from this study will uncover new therapeutic approaches for the treatment of sickle cell disease and other hemoglobinopathies.

PI_NAMEs: PESLAK, SCOTT ALAN (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: acute chest syndrome;Adult;Animal Model;Auxins;Avascular necrosis of bone;Award;beta Thalassemia;Bioinformatics;Blood;career;career development;Cell Culture Techniques;Cell Line;Cells;Cellular biology;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;CRISPR/Cas technology;Development;Dissection;Drug Targeting;Engineering;Erythrocytes;Erythroid;Erythroid Cells;experience;Fellowship;Fetal Hemoglobin;functional genomics;Funding;Future;GCN2 protein kinase;Gene Expression Regulation;genetic regulatory protein;genome editing;Global Change;Goals;Hematology;Heme;Hemoglobin;Hemoglobin concentration result;Hemoglobinopathies;Human;improved;in vivo;in vivo Model;Individual;inhibitor;insight;instructor;Internal Medicine;International;Kidney Diseases;Knowledge;Mass Spectrum Analysis;Mediating;Mentors;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncology;Outcome Study;Pathway interactions;Patients;Pediatric Hospitals;Pennsylvania;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Philadelphia;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physicians;Production;Protein Kinase;Protein Kinase Interaction;Protein phosphatase;Proteome;Regulation;Regulatory Pathway;Research;research and development;Research Personnel;Residencies;Resources;Role;Sampling;Scholars Program;Scientist;Sickle Cell;Sickle Cell Anemia;sickling;Signal Pathway;Signal Transduction;skills;small molecule;Stroke;Surveys;synergism;System;Techniques;Testing;Therapeutic;Training;transcriptome;transcriptome sequencing;Transplantation;Universities;Up-Regulation;Vocational Guidance;Xenograft procedure

PROJECT_TITLE: Cellular Signaling Pathways in the Regulation of Fetal Hemoglobin for Treatment of Sickle Cell Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Data Science;Genetics;Human Genome;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rheumatoid Arthritis

PI_NAMEs: RAYCHAUDHURI, SOUMYA  (contact)

PROJECT_TERMS: Acceleration;Algorithms;Architecture;Autoimmune Diseases;B-Lymphocytes;biomarker identification;Cell Communication;cell type;Cells;Clonal Expansion;Complex;Computational Biology;Data;Data Analytics;Data Science;Data Set;deep learning;Development;Discriminant Analysis;Disease;Event;experience;experimental study;Fibroblasts;Gene Expression;Genetic Transcription;Genomic approach;Goals;Grant;Heterogeneity;high dimensionality;Hospitals;Human Resources;Image;Image Analysis;image processing;imaging platform;Immune;Immunology;Individual;insight;Laboratories;large scale data;Lesion;machine learning classifier;Manuals;Medical;medical schools;Methods;monocyte;Morphologic artifacts;multidimensional data;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Physiological;Population;Positioning Attribute;Program Research Project Grants;programs;Protocols documentation;Research;Rheumatism;Rheumatoid Arthritis;Sampling;Series;single cell analysis;single cell genomics;single-cell RNA sequencing;Structure;success;System;Systemic Lupus Erythematosus;Systems Biology;T-Lymphocyte;technology/technique;Testing;Time;Tissue Stains;Tissues;Training;transcriptome sequencing;trend;Tuberculosis;Woman

PROJECT_TITLE: Computational systems immunology core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Social contact plays a critical role in brain health and disease, and loneliness is tightly linked with depression, psychosis, suicidal behavior, and many autonomic, immune, and metabolic disorders. It remains unclear how the brain regulates 'social homeostasis' to maintain the internal stability and balance of diverse social, emotional, and physical needs. This project will use a new conceptual model and state-of-the-art technology to establish social homeostasis as a biological neural control system, like those well established for other physiological conditions (e.g. hunger, thirst, sleep), which will provide insights for social processing that is disrupted among many disease states including autism spectrum disorder.

PI_NAMEs: MCHENRY, JENNA ANN (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;Adult;Aggressive behavior;Animals;autism spectrum disorder;autism symptoms;Autonomic nervous system disorders;awake;base;Behavior;Behavior Control;Behavioral;Biological;Body Temperature;Brain;Brain Diseases;brain health;Brain Mapping;Calcium;Caring;Cells;Cognitive;Communities;Complex;Confusion;control theory;Data;deep learning;Disease;drinking water;Eating;Elements;Emotional;Equilibrium;Event;experience;Experimental Models;Female;flexibility;Food;Genetic;Genetic Recombination;genetic technology;Head;Health;Heart Diseases;Homeostasis;Human;Hunger;Hypothalamic structure;Image;imaging study;Imaging technology;Immune;Immune System Diseases;Impairment;in vivo;Individual;Individual Differences;Insecta;insight;lens;Link;Literature;Location;Loneliness;male;Maps;Medial;Mediating;Medical;Mental Depression;Mental Health;Metabolic;Metabolic Diseases;Methodology;Microscope;millisecond;Modeling;Mood Disorders;motivated behavior;Mus;Nature;negative affect;neural;neural circuit;Neurons;neuroregulation;Neurosciences;novel;optogenetics;Organ;Partner in relationship;Pathologic;Phenotype;physical conditioning;Physiological;Play;Population;Population Dynamics;Positioning Attribute;Positive Valence;Predisposition;Premature Mortality;Preoptic Areas;Process;Psychoses;recruit;resilience;Resources;Role;Sensory;Series;Sleep;Sleep Disorders;social;Social Behavior;social contact;Social Controls;social engagement;Social Hierarchy;Social isolation;suicidal behavior;System;Techniques;Technology;Testing;Thirst;Time;two photon microscopy;Water

PROJECT_TITLE: Establishing Neural Control Systems for Social Homeostasis


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Lupus;Rheumatoid Arthritis

PI_NAMEs: DIAMOND, BETTY  (contact)

PROJECT_TERMS: Address;Age;Antibodies;Antigen-Presenting Cells;Antigenic Specificity;Antigens;Atypical lymphocyte;Autoantibodies;Autoimmune Diseases;Autoimmunity;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Blood;BLR1 gene;candidate identification;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Physiology;Cell Survival;Cells;chemokine;chemokine receptor;chronic autoimmune disease;Complement 3d Receptors;cytokine;Derivation procedure;design;Development;Disease;Exhibits;Family;Fibroblasts;Frequencies;Helper-Inducer T-Lymphocyte;Heterogeneity;Homing;Human;Immune;Immunologics;Immunology;In Situ;Infiltration;Inflammatory;interleukin-21;ITGAX gene;Kidney;Knowledge;Lupus;Lymphocyte;Lymphoid;Maps;Mediator;Memory B-Lymphocyte;Myeloid Cells;Natural Killer Cells;new therapeutic target;Pathogenicity;Pathway interactions;Patients;Peripheral;Phenotype;Plasma Cells;Plasmablast;Population;Process;Production;Resolution;Rheumatoid Arthritis;Stromal Cells;Syndrome;synergism;Synovial Fluid;Synovial Membrane;System;Systemic Lupus Erythematosus;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Tissues;transcriptome;transcriptomics;Work

PROJECT_TITLE: Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Orphan Drug;Physical Rehabilitation;Rare Diseases;Rehabilitation

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  Tongue cancer and its treatment affect tongue structure and function, yet little is known about how the changes in tongue structure due to varying degrees of resection and reconstruction affect the formation of functional units of tongue motion during speech. We propose to use novel integrated platform tools to identify functional units seamlessly with unprecedented resolution and precision. Upon success of this proposal, our integrated framework has the potential to aid in an increased understanding of speech motor control strategies in healthy controls and the patient group, thereby benefiting patients through improved diagnosis, treatment, and rehabilitative strategies.

PI_NAMEs: WOO, JONGHYE  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3-Dimensional;Acoustics;Address;Affect;Aftercare;Anatomy;Atlases;Behavior;biomechanical model;Biomechanics;Cessation of life;Clinical;clinical practice;Complex;Computing Methodologies;Data;Death Rate;deep learning;Deglutition;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Elements;Evaluation;Excision;Exhibits;Fiber;functional outcomes;Geometry;Glossectomy;Goals;Grouping;holistic approach;Impairment;improved;in vivo;Incidence;insight;Joints;Knowledge;Learning;Link;Magnetic Resonance Imaging;malignant mouth neoplasm;Malignant Neoplasms;malignant tongue neoplasm;Maps;Measurement;Measures;Methods;Modeling;Motion;motor control;multimodality;Muscle;Muscle Fibers;muscular structure;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathologic;Patients;Physiological;Postoperative Period;Predictive Value;Procedures;Production;Prognosis;Proxy;Publishing;Radiation therapy;reconstruction;rehabilitation strategy;Rehabilitation therapy;Research;Resolution;signal processing;spatiotemporal;Speech;Speech Intelligibility;Standardization;Structure;success;Surface;System;Techniques;Testing;Time;Tissue Grafts;Tissues;Tongue;tool;treatment planning;tumor;Work

PROJECT_TITLE: A holistic approach to identifying functional units of tongue motion during speech

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

PHR: Continuing support for our integrative pre-doctoral training program in the neuroscience of drug abuse will ensure a cohort of researchers who are well prepared to develop, study and evaluate new treatments for the multi-faceted, multi-dimensional problem of drug abuse. Trainees integrate experimental approaches from neuroscience, psychology, and population health in their coursework and research training to optimize their preparation for careers in drug abuse.

PI_NAMEs: HOHMANN, ANDREA GRACE;MACKIE, KENNETH  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TITLE: INTEGRATIVE PREDOCTORAL TRAINING IN DRUG ABUSE RESEARCH AT INDIANA UNIVERSITY