NIH_SPENDING_CATS: Aging

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Emerging findings show complex functions of p38 MAPK in development and aging. We are working to understand how these p38 MAPK functions work in a non-cell autonomous manner to promote lysosome regeneration during aging. The role of stress-responsive pathways supporting homeostatic physiological functions provides an opportunity to reveal key mechanisms underlying integrity of tissues during aging.

PI_NAMEs: WEAVER, BENJAMIN P. (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Acceleration;Adult;Aging;Auxins;Biochemical;Biogenesis;Caenorhabditis elegans;Cells;Cellular biology;cellular targeting;Communication;Communication Programs;Complex;Data;Debility;Defect;Development;Distal;Epidermis;Event;Exhibits;extend lifespan;FUS-1 Protein;Future;gain of function;Genetic Epistasis;Genetic Screening;Germ Lines;Goals;Heterogeneity;Homeostasis;in vitro Assay;intercellular communication;Interdisciplinary Study;Label;Life;Lysosomes;macromolecule;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;member;Metabolic;Molecular;mutant;Natural Immunity;Natural regeneration;Nature;Nerve;Nerve Degeneration;Neurons;novel;p38 Mitogen Activated Protein Kinase;Pathology;Pathway interactions;Physiological;programs;Proteomics;Reproducibility;RNA Interference;RNA interference screen;Role;scaffold;Signal Transduction;Stress;System;Testing;Tissues;tool;Translating;Work

PROJECT_TITLE: Unmasking p38 MAPK Functions in Lysosome Homeostasis during Development and Aging

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: TX

PHR: PROJECT NARRATIVE Early-onset CRC, which is especially prevalent among under-served individuals, is difficult to diagnose because routine screening tests are not recommended until age 45 and, even when younger patients report red-flag symptoms for CRC, the symptoms can be misattributed to benign causes and not followed up with CRC testing. No previous study has assessed follow-up with early onset CRC testing for patients reporting red-flag symptoms in a safety-net healthcare system. Our proposed work will expand data from a large NIH- funded safety-net cohort to study CRC test order, testing and cancer diagnoses among patients aged 18-49 who report a red-flag symptom, with the goal of better understanding healthcare delivery for this vulnerable group.

PI_NAMEs: HUGHES, AMY E (contact);NAIR, RASMI GIRIJAVALLABHAN

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Abdominal Pain;Address;Advanced Malignant Neoplasm;Age;Age of Onset;Age Years;aged;Algorithms;associated symptom;Benign;Body Weight decreased;cancer diagnosis;Case/Control Studies;clinically relevant;cohort;Cohort Studies;colon cancer patients;Colorectal;colorectal cancer screening;Constipation;County;Data;data management;Data Set;design;Development;Diagnosis;Diagnostic;Diarrhea;Disease;Early Diagnosis;early onset;early onset colorectal cancer;Electronic Health Record;Epidemiology;ethnic minority;experience;Failure;Family history of;follow up assessment;follow-up;Funding;Genetic;Goals;health care availability;health care delivery;Health system;Healthcare Systems;Hemorrhage;Incidence;Individual;Inflammatory;Inflammatory Bowel Diseases;Intestines;Iron deficiency anemia;Knowledge;Light;Malignant Neoplasms;minority patient;neglect;Outcome;patient subsets;Patients;Persons;Physicians;Polyps;Positioning Attribute;Precancerous Polyp;Prevalence;Primary Care;primary care patient;Process;Public Health;racial minority;Recommendation;Rectum;Reporting;response;routine screening;safety net;Sampling;screening;Screening for cancer;secondary analysis;Site;Stage at Diagnosis;Symptom Burden;Symptoms;Syndrome;Techniques;Testing;Time;timeline;Underserved Population;Uninsured;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: Early onset colorectal cancer: from symptoms to treatment in a large, safety-net cohort

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Plasmodium vivax is a major obstacle to malaria control and elimination due to its ability to form persistent liver stage forms known as hypnozoites. New therapies to eliminate hypnozoites are needed because these forms are responsible for up to 85% of P. vivax infections, and current therapies cannot be widely administered due to contraindications in large portions of at-risk populations. This project will address this public health problem by determining when and how P. vivax commits to dormancy, which is needed to develop new approaches to eliminate hypnozoites.

PI_NAMEs: JOYNER, CHESTER J. (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Address;Africa;Area;Asia;Biology;Blood;Brazil;comparative;Country;Culicidae;Data;Development;Disease;Economic Burden;Exhibits;experimental study;Future;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Transcription;Goals;Hepatocyte;Human;improved;In Vitro;Individual;Infection;innovation;Intervention;Invaded;Knowledge;Koreans;Liver;Malaria;Molecular;Molecular Evolution;Morbidity - disease rate;new therapeutic target;nonhuman primate;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Parasites;Pathway interactions;Phenotype;Plasmodium vivax;Population;Populations at Risk;Procedures;Process;programs;Property;Public Health;Publishing;Regulation;Relapse;Reproducibility;Research;RNA-Binding Proteins;Role;Salivary Glands;single cell genomics;single-cell RNA sequencing;socioeconomics;Sporozoites;Techniques;Testing;Transcript;transcriptome;transcriptomics;transmission process;virtual;Vivax Malaria;Work

PROJECT_TITLE: Comparative transcriptomics of Plasmodium vivax strains to understand hypnozoite formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-D (02)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative Despite the success of chimeric antigen receptor T (CAR T) cell therapies in treating lymphomas, it remains challenging to target solid tumors safely and effectively without impacting healthy tissues. However, targeting CAR T cells to metabolites that are enriched or depleted in the TME, in addition to tumor cell surface antigens, may improve the efficacy of this approach for solid tumors. In this project, we target combinations of tumor- specific antigens and TME metabolites by engineering modular CARs that link the extracellular detection of these ligands with the activation of T cell signaling pathways for tumor destruction.

PI_NAMEs: GLASGOW, ANUM AZAM (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Affinity;Agonist;Antigen Targeting;Antigens;Binding;Binding Sites;Biological Assay;Breast Cancer Cell;Breast Cancer Model;cancer therapy;CAR T cell therapy;Cell Adhesion Molecules;Cell Culture Techniques;cell killing;Cell Line;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Coculture Techniques;Collaborations;Complex;Couples;cytokine;Cytokine Signaling;Cytolysis;Data;design;Detection;efficacy evaluation;efficacy testing;Engineering;Environment;ERBB2 gene;exhaustion;extracellular;G-Protein-Coupled Receptors;Geometry;Homologous Gene;Homologous Protein;Human;humanized mouse;Immunoglobulin Fragments;improved;In Vitro;in vivo;innovation;Libraries;Ligand Binding;Ligands;Link;Logic;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;Membrane;Metabolic;Methods;Modality;Modeling;Molecular Conformation;molecular dynamics;Monitor;mouse model;nanobodies;Nature;neoplastic cell;nuclear factors of activated T-cells;Physiological;pre-clinical;preservation;Production;Protein Engineering;Protocols documentation;prototype;Proxy;receptor;Receptor Activation;receptor binding;Receptor Cell;Reporter;response;Safety;scaffold;screening;sensor;Signal Pathway;Signal Transduction;small molecule;Solid Neoplasm;Structure;success;Surface Antigens;T-Cell Activation;T-Lymphocyte;Technology;Testing;Therapeutic;Tissues;tumor;Tumor Antigens;tumor microenvironment;Universities;Work;Yeasts

PROJECT_TITLE: Computationally designed, small molecule-responsive cell receptors for treating solid tumors

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Mucormycosis incidence is on the rise, with the overall mortality rate of over 50%, and disseminated disease being nearly universally fatal, as currently available treatments are limited. Our goal is to elucidate the evolutionary history of symbiotic associations between the Mucoromycotina fungi and the endosymbiotic bacteria often found in clinical isolates, focusing on population-level processes, including fungal adaptation to mammalian hosts and contributions of 6-methyladenine (6mA) DNA epigenetic modifications shared by Mucoromycotina and bacteria as means of communication between the partners. Findings of this project will inform new mycosis therapies relying on inhibition of 6mA DNA methylation in both partners.

PI_NAMEs: PAWLOWSKA, TERESA E (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adenine;Affect;anti-microbial drug;Bacteria;Betaproteobacteria;Chemicals;Clinical;Communication;community science;COVID-19;Data;Death Rate;Disease;DNA;DNA Methylation;DNA Modification Methylases;DNA Modification Process;DNA Restriction-Modification Enzymes;Environment;Enzymes;Epigenetic Process;epigenome;epigenomics;Eukaryota;Foundations;Fungal Genes;fungus;Future;Gene Expression;genetic analysis;Genetic Transcription;Genome;genome-wide analysis;genomic data;Genomics;Goals;Health;Human;human pathogen;Immune;Incidence;Individual;Infection;inhibitor;insight;Joints;Maintenance;Mammals;Mediating;Medical;Metabolism;methylome;Modeling;Modification;Mucormycosis;Mycoses;novel;opportunistic pathogen;Organism;Outcome;pathogenic fungus;Patients;Pattern;pharmacologic;Population;Population Genetics;Population Process;Preparation;Process;Recording of previous events;Reproductive Biology;Resistance;response;Rhizopus;Role;Shapes;Source;Structure;Study models;Symbiosis;Testing;Therapeutic;tool;traumatic wound;treatment strategy;Virulence;Work;Wound Infection

PROJECT_TITLE: Uncovering the evolutionary history of bacterial endosymbiosis in opportunistic fungal pathogens of humans

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: Narrative Glioblastoma (GBM) is the most devastating primary brain tumor in adults, characterized by enhanced invasion and proliferation and therapy resistance. This project will evaluate the role and therapeutic implications of the SPAK and OSR1 kinases in GBM. Our long-term goal is to develop a research program focused on identifying druggable signaling pathways that regulate GBM cell invasion and proliferation.

PI_NAMEs: SCHIAPPARELLI, PAULA V (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Adult;Alanine;angiogenesis;Apoptosis;Apoptotic;Automobile Driving;Biology;Brain;Brain Neoplasms;brain parenchyma;brain tissue;cancer cell;cancer survival;Cell Death;cell motility;Cell Survival;Cell Volumes;Cells;Cellular Stress;chemoradiation;Chemoresistance;chemotherapeutic agent;chemotherapy;Collaborations;Combined Modality Therapy;Confined Spaces;Data;DNA Damage;effective therapy;efficacy testing;Environment;Foundations;gene network;Genetic;Glioblastoma;Glioma;Goals;Heterogeneity;Homeostasis;Human;improved;In Vitro;in vivo;Invaded;Ionic Strengths;Ions;Laboratories;Life Expectancy;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Mediating;migration;Mitogen-Activated Protein Kinase Kinases;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;neoplastic cell;novel;novel therapeutic intervention;Oncogenic;Operative Surgical Procedures;Osteosarcoma;Oxidative Stress;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;pharmacologic;phosphoproteomics;Phosphorylation;Phosphotransferases;Primary Brain Neoplasms;Primary carcinoma of the liver cells;programs;Proliferating;Proline;protein activation;Proteins;Proteomics;Public Health;Quality of life;Radiation;radiation resistance;Radiation therapy;Radiation Tolerance;Recurrent disease;Recurrent tumor;Regulation;Research;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;small molecule inhibitor;Sodium-Potassium-Chloride Symporters;Solid Neoplasm;standard of care;stemness;Stimulus;Stress;symporter;temozolomide;Testing;Therapeutic;therapy resistant;Tissues;TNFRSF1A gene;Treatment Efficacy;tumor;tumor growth;Tumor Promotion;tumor xenograft;Water;Work;Xenograft Model

PROJECT_TITLE: Evaluating the role of SPAK and OSR1 kinases in glioblastoma chemotherapy resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-Y (55)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Aphasia;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: This project seeks to enhance the value of the AphasiaBank database and tools for the study of spoken language and communication as used by people with aphasia. We will do this through the introduction of innovative methods for automatic speech recognition, discourse analysis, gesture analysis, corpus analysis, and a new system called collaborative commentary. We will apply these new methods to the analysis of the current database, as well as many new corpora. We will configure these new methods for widespread use by both researchers and clinicians.

PI_NAMEs: MACWHINNEY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Aphasia;automated speech recognition;Communication;Databases;Discourse analysis;Gestures;innovation;Language;Methods;Persons;Published Comment;Research Personnel;shared database;System;tool

PROJECT_TITLE: AphasiaBank: A Shared Database for the Study of Aphasic Communication

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Drug Abuse (NIDA only);Estrogen;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: PROJECT NARRATIVE Women experience greater nicotine use vulnerability in addition to higher rates of cancer, heart attacks, and mortality from smoking; hormonal contraceptives heighten this nicotine use vulnerability in addition to exacerbating women’s already greater risk for adverse smoking related health consequences. In turn, massive gains would result from a better understanding of mechanisms that underly this enhanced nicotine use vulnerability and its augmentation by hormonal contraceptives. The long-term objective of this research program is to provide a behavioral mechanistic understanding of how synthetic hormones contained in contraceptives influence nicotine intake, ultimately providing the preclinical basis for which researchers and practitioners can develop better cessation treatments and reduce health disparities caused by enhanced nicotine use vulnerability and comorbid contraceptive use in women.

PI_NAMEs: MCNEALY, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: KAUTZ, MARY A

PROJECT_TERMS: addiction;analog;Attenuated;Automobile Driving;Basic Science;Behavioral;Biology;Chronic;Cigarette;Clinical;comorbidity;Contraceptive Agents;Contraceptive Usage;design;Development;Disparity;Dose;Environmental Risk Factor;Estradiol;Estrogens;Ethinyl Estradiol;Exhibits;experience;Female;Formulation;Gonadal Steroid Hormones;Health;Hormonal;hormonal contraception;Hormones;Human;Infusion procedures;Injections;Intake;Intravenous;Levonorgestrel;Light;Link;Literature;Maintenance;Malignant Neoplasms;men;Menopause;mortality;Myocardial Infarction;Nicotine;Nicotine Dependence;nicotine reward;nicotine self-administration;nicotine use;Nicotine Use Disorder;Ovariectomy;Ovary;Pharmaceutical Preparations;Play;pre-clinical;Pre-Clinical Model;pre-clinical research;preclinical study;Premenopause;Progesterone;Progestins;programs;protective effect;Psychological reinforcement;Public Health;Publishing;Rattus;Reduce health disparities;reinforcer;Reproductive Health;Research;Research Personnel;Rewards;Risk;Rodent;Role;role model;Saline;Science;Scientific Advances and Accomplishments;Scientist;Self Administration;sex;Smell Perception;Smoke;Smoker;Smoking;smoking relapse;Stimulus;symposium;Taste Perception;Testing;vaping;Vision;visual stimulus;Woman;Women's Group;Work;xenoestrogen

PROJECT_TITLE: Contraceptive hormone impacts on the primary reinforcing and reward-enhancing effects of nicotine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Being able to map specific cell types affiliated with vulnerable brain regions and their network connections would be a critical advancement in our ability to predict age-related processes that lead to irreversible damage. We will develop a unique multi-scale reference dataset and network-based analysis strategy to investigate macroscale network architecture and cell-type specific microstructure in the macaque monkey. The macaque is uniquely positioned to provide a mechanistic understanding of processes related to age-related decline using both translational in vivo MRI and invasive histology markers.

PI_NAMEs: RAVEN, ERIKA PRATT (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;Age;age acceleration;age related;age related decline;age related deterioration;aged;aging brain;Anatomy;Animal Model;Area;Astrocytes;Autopsy;Biological;Biological Aging;Biological Markers;Brain;Brain Mapping;Brain region;Cell Death;Cell Density;Cell Physiology;cell type;Cells;Cellular Morphology;cerebral atrophy;clinically relevant;cohort;Collaborations;Communication;Communities;connectome;contrast imaging;Data;Data Set;density;design;Deterioration;Development;Disease;Disease Progression;Early Diagnosis;experience;FAIR principles;Future;Glial Fibrillary Acidic Protein;Grain;Health;healthy aging;Histologic;Histology;Histopathology;Human;human old age (65+);Image;in vivo;indexing;Individual;Intervention;Joints;late life;Length;life span;Link;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Maps;Metabolic;Microglia;microscopic imaging;Microscopy;Modeling;Molecular;Monkeys;Morphology;multimodality;multiscale data;myelination;network architecture;Network-based;neural;Neurodegenerative Disorders;neuroinflammation;neuron loss;neuronal cell body;non-invasive imaging;nonhuman primate;open data;open source;Pathway Analysis;Pathway interactions;Pattern;Population;Populations at Risk;Positioning Attribute;Process;receptor;repaired;Research;Resolution;Risk;sharing platform;Specificity;Structure;Swelling;Synapses;Techniques;Technology;Testing;Time;tool;Translating;Translations;Travel;Variant;Visualization;white matter;Work

PROJECT_TITLE: Connecting across Scales: Integration of Cell-Specific Microstructure within Long-Range Brain Networks in the Macaque Monkey

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: NARRATIVE Herpes Simplex Virus (HSV) is a ubiquitous human pathogen that can cause significant morbidity and mortality in humans and has been implicated in neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis. Here we propose to investigate the molecular mechanism of the antiviral response by the human stress response protein PML. We will focus on PML’s sumoylation activity and its ability to target and silence viral genes during the early stages of infection to provide a detailed understanding of the key events in the formation of anti- viral PML nuclear bodies which is currently missing.

PI_NAMEs: BEZSONOVA, IRINA  (contact);WELLER, SANDRA K

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: acute infection;Address;Affect;Afferent Neurons;Affinity;Alzheimer's Disease;Amino Acids;Anti-viral Response;arms race;Binding;biological adaptation to stress;Biological Assay;Biophysics;Blindness;Body Size;C-terminal;Cells;Cellular biology;congenital infection;Cornea;Defect;Disease;DNA;DNA Binding;DNA Binding Domain;DNA biosynthesis;DNA Damage;Encephalitis;Enzymes;Event;Evolution;Family member;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Gene Expression;Genes;Genetic;Genitalia;Genome;Growth;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Human;Human Herpesvirus 2;human pathogen;Immune response;In Vitro;in vitro activity;Infection;insight;Interferons;intermolecular interaction;Label;latent persistent infection;Lesion;Life;Life Cycle Stages;Ligase;Maintenance;Malignant Neoplasms;Mediating;Molecular;Morbidity - disease rate;mortality;Multiple Sclerosis;mutant;N-terminal;Neurodegenerative Disorders;NMR Spectroscopy;Nuclear;Nuclear Protein;nuclease;Oral;Oxidative Stress;Phase;Physical condensation;PicoGreen;Plaque Assay;Play;Population;Process;Property;Protein Isoforms;protein oligomer;Proteins;recruit;Recurrent disease;response;Role;scaffold;sensor;Series;Simplexvirus;Site;Small Ubiquitin-Related Modifier Proteins;Specificity;Stress;Structure;Sumoylation Pathway;Tertiary Protein Structure;Testing;transcription factor PML;Transfection;ubiquitin-protein ligase;Viral;viral DNA;Viral Genes;Viral Genome;Virus;Virus Diseases;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular mechanisms of sensing nuclear stress and launching antiviral defense by PML

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The protist pathogen Cryptosporidium is a water-borne pathogen that infects immune competent and immunocompromised humans and animals in all countries but is a major cause of diarrhea in infants under a year of age in developing countries. We have discovered polycistronic transcription in C. parvum. This is surprising, as it is not common in eukaryotes and has never been reported in the Apicomplexa. The proposed work seeks to validate these transcripts and begin studies of how they contribute to gene regulation in this important pathogen.

PI_NAMEs: KISSINGER, JESSICA C (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;Age Years;Animals;Anti-sense RNA;Apicomplexa;Appearance;asexual;ATAC-seq;Biology;Cell Culture Techniques;Cells;Chromatin;Cistrons;Code;Collaborations;Communities;Complex;Country;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Curiosities;Data;design;Developed Countries;Developing Countries;Development;Diarrhea;Dissection;DNA;Double-Stranded RNA;Etiology;Eukaryota;experimental study;Fractionation;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Green Algae;Hour;Human;Immunocompetent;Immunocompromised Host;In Vitro;Infant;Infection;Label;Learning;Life;Life Cycle Stages;Location;Methods;Modification;Molecular Genetics;Morphologic artifacts;novel;Nucleotides;Organism;Organoids;Outcome;pathogen;Pattern;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;Process;promoter;Proteins;Purines;Pyrimidines;Reporting;response;Reverse Transcriptase Polymerase Chain Reaction;ribosome profiling;RNA;single molecule;Sporozoites;telomere;Testing;Time;tool;Transcript;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transfection;Transgenes;Translating;Translations;Untranslated Regions;Untranslated RNA;waterborne pathogen;Work

PROJECT_TITLE: Gene regulation in Cryptosporidium

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The proposed project is relevant to the public because sarcoidosis is a common interstitial lung disease of unknown cause that often causes chronic disability and, in some cases, premature death, and for which effective and affordable treatments are not currently available. The successful completion of this project will provide novel insights into the pathogenesis of sarcoidosis to inform the development of more effective treatments, including repurposing existing therapeutic agents. Thus, the proposed research and future scientific and clinical implications are relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will reduce the burdens of illness and disability, and is responsive to the NHLBI strategic vision as relates to understanding human biology, reducing human disease, and advancing translational research.

PI_NAMEs: CROUSER, ELLIOTT D (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;Affect;Aldosterone;Antioxidants;aspirate;Attenuated;Automobile Driving;Biological Markers;burden of illness;Cells;Cessation of life;Characteristics;Chronic disability;Circulation;Clinical;Clinical Trials;Collagen;Crohn's disease;Data;Development;disability;Disease;Drug Modulation;effective therapy;experience;Fibrosis;Funding Mechanisms;Future;Goals;Granuloma;Granulomatous;Granulomatous disease;Heart;heme oxygenase-1;Hormones;Human;Human Biology;human disease;human tissue;Immune;Inflammasome;Inflammation;Inflammatory;inhibitor;innovation;insight;Interstitial Lung Diseases;Investigation;Knowledge;Laboratories;Link;Lung;Macrophage;Mediating;Mineralocorticoid Receptor;Mission;Mitochondria;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;National Heart, Lung, and Blood Institute;new therapeutic target;novel;Organ;Oxidants;Oxidation-Reduction;Pathogenesis;Pathologic;Pathway interactions;Patients;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Phosphorylation;Play;premature;Production;Receptor Activation;Regulation;Renin-Angiotensin-Aldosterone System;Research;response;Role;Sarcoidosis;Signal Pathway;Signal Transduction;STAT3 gene;Strategic vision;targeted treatment;Therapeutic Agents;Time;Tissues;Transforming Growth Factor beta;Translational Research;United States National Institutes of Health;virtual

PROJECT_TITLE: Redox Regulation of Sarcoidosis Granulomas and Fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Women's Health Research

ORG_CITY: NORTHRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

ORG_STATE: CA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT – PROJECT NARRATIVE Metastatic triple-negative breast cancer (TNBC) patients have poor clinical outcomes, in part, because there are no targeted therapies approved to treat this aggressive breast cancer subtype. By elucidating new post-translational mechanisms of eIF5A1/2-dependent TGFβ/fibronectin-induced heterogeneity and metastasis within primary and premetastatic niches, the proposed studies have the potential to identify new therapeutic strategies for abrogating TNBC progression. Additionally, this work has broad applicability across the field of oncology as many of the molecular regulators being investigated in this proposal have been reported to be altered or dysregulated in other solid tumor types where cancer metastasis is a primary cause of patient mortality.

PI_NAMEs: KELBER, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;Adhesions;Affect;aggressive breast cancer;Anti-Inflammatory Agents;Biochemistry;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Cancer Biology;cancer cell;Cancer Prognosis;cancer subtypes;cancer type;Cell Cycle Kinetics;Cells;Cellular biology;Chemotherapy-Oncologic Procedure;Clinical;Complex;Cytoplasm;Data;Eukaryotic Initiation Factors;Fibronectins;Flow Cytometry;Funding;genetic manipulation;Goals;Heterogeneity;Human;Immunofluorescence Immunologic;improved;in vivo;Inflammatory;innovation;Integrins;Intervention;Invaded;Knowledge;Laboratories;LCN2 gene;Mediating;Methods;Modeling;Molecular;mortality;mouse model;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;nucleocytoplasmic transport;Oncology;Outcome;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Periodicity;pharmacologic;Pharmacology;Phosphotransferases;pre-clinical;Pre-Clinical Model;Primary Neoplasm;programs;Proteins;public health relevance;Publishing;Reporting;Research;response;screening;Signal Transduction;Site;Solid Neoplasm;spatiotemporal;targeted treatment;Testing;Tissues;Transforming Growth Factor beta;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor progression;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Spatiotemporal mechanisms of eIF5A1/2-mediated metastasis in triple-negative breast cancer


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE This research will test the efficacy of enrichment interventions focused on parent-infant interactions via singing, music-listening, and book-reading, for improving parent and infant health. Primary outcomes of interest include improvements to infant and parent mood, infant sleep quality, infant ability to recover from distress, and parent well-being. The interventions are low-cost and low-effort for parents, so may have outsized impacts, especially in underprivileged families and first-time parents.

PI_NAMEs: MEHR, SAMUEL A (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Achievement;Adherence;Adoption;Age;aged;Attention;Behavior;Books;Caring;Cellular Phone;Child;Child Rearing;childhood adversity;contextual factors;cost;Data;Data Collection;demographics;design;Development;Distress;Drops;early childhood;early experience;Ecological momentary assessment;efficacy testing;Environment;experience;Face;falls;Family;Family Characteristics;feasibility testing;Frequencies;Funding;Future;group intervention;Health;Health Benefit;Health Status;Hearing;Hour;improved;Income;Inequality;Infant;Infant Care;Infant Health;infant outcome;infant temperament;interest;Intervention;intervention cost;Intervention Studies;Kangaroo-Mother Care;Lead;Learning;Life;Life Experience;Measurable;Measures;mental development;Mental Health;Middle Insomnia;Moods;Music;Music Therapy;National Institute of Child Health and Human Development;negative affect;Outcome;Parents;Personal Satisfaction;Phase;physical conditioning;premature;primary outcome;programs;Psychophysiology;Random Allocation;Randomized;randomized trial;Reading;Recording of previous events;Recovery;Reporting;Research;resilience factor;Resources;Risk;Risk Factors;Skin;Sleep;sleep quality;Social support;socioeconomic disadvantage;Speech;Surveys;Temperament;Testing;Text Messaging;Time;tool;United States National Institutes of Health;vocalization;Work

PROJECT_TITLE: Effects of enriched parent-infant interaction on health in early life

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Cervical insufficiency or incompetence (CI) describes the inability of the uterine cervix to retain a pregnancy in the absence of the signs and symptoms of clinical contractions, or labor, or both in the second trimester. Currently, there are no objective tests to evaluate cervical tissue strength as a means to confirm a diagnosis of CI and the diagnosis of CI cannot be made or excluded outside of pregnancy by any test. The objective of this study is to determine if the blood perfusion and/or microvascular pressure around the internal os of the uterine cervix can distinguish patients with a history of CI (presumably “weak” cervix) from normal controls in a non-pregnant state.

PI_NAMEs: NAM, KIBO  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: abortion;Area;Biological Markers;Biopsy;Biopsy Specimen;Blood flow;blood perfusion;Blood Vessels;Cervical;cervical remodeling;Cervix Incompetence;Cervix Uteri;Clinical;Collagen;comparison control;contrast enhanced;Contrast Media;Curettage procedure;Defect;Diagnosis;diagnostic criteria;Discipline of obstetrics;driving force;Estimation Techniques;Etiology;Exclusion;experience;Extracellular Matrix;Failure;Frequencies;Functional disorder;Gases;Genetic;Hepatic;Incidence;Injury;Intercellular Fluid;intracardiac pressure;intravenous administration;Length;Measurement;Mechanics;Methods;Microbubbles;Muscle function;novel;Operative Surgical Procedures;Organ;parous;Patients;Physical Examination;Pregnancy;premature;pressure;pressure sensor;Recording of previous events;Reporting;Second Labor Stage;Second Pregnancy Trimester;Severities;Signal Transduction;Signs and Symptoms;Smooth Muscle;Smooth Muscle Myocytes;Sphincter;Term Birth;Testing;Tissues;Transvaginal Ultrasound;Trauma;tumor;ultrasound;Uterus;Vascularization;Venous Pressure level;Woman

PROJECT_TITLE: Assessment of Uterine Cervical Insufficiency using 4D Contrast-Enhanced Ultrasound

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Herpes simplex viruses cause cold sores and sexually transmitted infections, and can also cause the more serious complications of neonatal infections, blindness, and fatal encephalitis. The purpose of this research is to determine how the herpesvirus initiates infection in humans by studying the entry of virus into host cells. Greater understanding of the virus entry processes will help to identify novel approaches to prevent herpes infections.

PI_NAMEs: NICOLA, ANTHONY V (contact)

PROJECT_TERMS: Acyclovir;Biochemical;Biochemistry;Biological Assay;Blindness;Caveolins;Cell Fractionation;Cell membrane;Cell Nucleus;cell type;Cells;Cellular biology;Centrifugation;Cholesterol;Clathrin;Complex;Confocal Microscopy;Data;Development;Disease;Drug resistance;Drug Targeting;Dynamin;Early Endosome;Electron Microscopy;Encephalitis;Endocytosis;Endocytosis Pathway;Epithelial Cells;Experimental Designs;Foundations;genital infection;Golgi Apparatus;Herpes Labialis;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;human pathogen;Immunocompromised Host;Impairment;in vivo;Infection;inhibitor;innovation;Integration Host Factors;Intervention;Intracellular Transport;keratinocyte;late endosome;latent infection;Lysosomes;Mediating;Membrane Fusion;Microscopic;Microscopy;Modeling;Molecular Virology;Monitor;Morbidity - disease rate;mortality;neonatal infection;novel;novel strategies;pathogen;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiological;Pilot Projects;prevent;Prevention;Primary Infection;Process;recurrent infection;Reporter;Research;resistant strain;retrograde transport;Role;Route;Sexually Transmitted Diseases;Shapes;Simplexvirus;Site;spatiotemporal;Specificity;Supporting Cell;Techniques;Therapeutic;Time;trans-Golgi Network;uptake;Vaccines;Vesicle;Viral;Virion;Virus;visual tracking

PROJECT_TITLE: The Golgi complex and HSV entry

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Contraception/Reproduction;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative: Uterine fibroids are common, contributing an annual estimated $34.4 billion financial burden. The risk of uterine fibroids is 2-3 times higher for Black women, and they are younger at diagnosis and have more symptoms than White women. Exposure to adversity during childhood may contribute to the development of uterine fibroids.

PI_NAMEs: VINES, ANISSA I (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Address;Adrenal Glands;Adult;adverse childhood events;African American;African American Women;Age;Age of Onset;aged;Attenuated;Behavioral;Biological;Black race;black women;boys;Buffers;C-reactive protein;Cessation of life;Child;Child Abuse;Child Health;Child Sexual Abuse;Childhood;children of color;Chronic;clinical diagnosis;contextual factors;coping;Coping Skills;cost;critical period;cytokine;Data;Deterioration;Development;Diagnosis;Disease susceptibility;disparities in morbidity;Down-Regulation;early childhood;early experience;early life adversity;early life stress;early onset;Economics;Emotional;emotional abuse;Enrollment;Environmental Risk Factor;experience;Exposure to;Family;Female;Fibroid Tumor;Financial Hardship;follow-up;Foundations;girls;Growth;Gynecologic;Health;Health behavior;health equity;Hemorrhage;Hormonal;hormone regulation;hypothalamic-pituitary-adrenal axis;Hysterectomy;improved;Incidence;Inflammation;Inflammatory;interest;Intervention;Knowledge;Lead;Life;Life Cycle Stages;Life Style;Link;Measures;Medical;Mental Health;Modeling;National Institute of Environmental Health Sciences;neglect;Operative Surgical Procedures;Outcome;Ovarian hormone;Pain;Participant;Pathway interactions;physical abuse;Physical activity;Prevalence;Prevention;Probability;Production;Progesterone;Prospective Studies;Psychosocial Factor;psychosocial resources;Public Health;Quality of life;racial disparity;Recording of previous events;Reporting;reproductive;reproductive hormone;Research;Research Personnel;research study;response;Risk;Risk Factors;Role;social factors;social relationships;Social support;socioeconomic disadvantage;Socioeconomic Status;Standardization;Stress;stressor;supportive environment;surgical disparities;Surveys;symptomatology;Symptoms;Time;Treatment/Psychosocial Effects;ultrasound;Up-Regulation;Uterine Fibroids;Victimization;Violence;Visit;Weight;White Women;Woman;Work

PROJECT_TITLE: Early Life Adversities and the Risk of Uterine Fibroids

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Bioengineering;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Cutaneous squamous cell carcinoma (cSCC) is a highly-prevalent form of skin cancer that causes an estimated 15,000 deaths with 1.8M new diagnoses each year in the United States alone. This high prevalence and mortality risk creates a tremendous need for effective treatment selection strategies, so that patients at risk for poor outcomes can benefit from more aggressive treatments while low-risk patients can be spared the corresponding side effects and costs. We propose to develop artificial intelligence algorithms to help stratify cSCC patients into low risk or high risk based on the histopathology images from their biopsy.

PI_NAMEs: LOTTER, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;aggressive therapy;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Automobile Driving;Biological Models;biomarker discovery;Biopsy;Black Box;Blood Vessels;Cancer Etiology;Cessation of life;chemotherapy;Clinical;clinical application;clinical practice;cost;Data Set;Detection;Disease;disease diagnosis;Educational Curriculum;effective therapy;Excision;feature detection;Frequencies;Guidelines;Heterogeneity;High Prevalence;high risk;Histologic;Histopathology;Hospitals;Human;Image;improved;Invaded;Label;Learning;learning strategy;Lesion;lymphatic Invasion;Malignant Neoplasms;Methods;Modeling;mortality;mortality risk;Nature;neural;Newly Diagnosed;novel;Oncology;Outcome;Pathology;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;Predictive Factor;preventable death;Prognosis;Prognostic Marker;prognostic model;Random Allocation;repository;Risk;Risk Factors;risk prediction;Sampling;Selection for Treatments;Series;side effect;simulation;Skin Cancer;skin squamous cell carcinoma;Slide;Structure;Techniques;Training;treatment optimization;treatment strategy;tumor;United States;Validation;Visualization;whole slide imaging;Woman

PROJECT_TITLE: Improving prognosis prediction and therapy selection for cutaneous squamous cell carcinomas using artificial intelligence

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: BINGHAMTON

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: Project Narrative The proposed research is relevant to public health because it focuses on interactions between two commonly co-occurring gastrointestinal bacteria pathogens, both of which are classified in the top antibiotic resistance threat levels in the United States by the Centers for Disease Control. Understanding how these two bacteria interact will be critical to developing therapeutics which do not inadvertently benefit one species. The proposed research is relevant to the part of NIAID’s mission devoted to understanding how antibiotic-resistant microbes cause disease.

PI_NAMEs: MCKENNEY, PETER T (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Affect;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Biological Assay;Calibration;Candidate Disease Gene;Cell surface;Cells;Centers for Disease Control and Prevention (U.S.);Classification;Clostridium difficile;Coculture Techniques;Collection;Data;Development;Disease;Enterococcus;Enterococcus faecalis;Equilibrium;experimental study;feeding;gastrointestinal;gastrointestinal bacteria;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;gut microbiota;Human;Infection;innovation;Knowledge;Laboratories;Libraries;Mediating;member;Membrane Proteins;Metabolic;Microbe;microbiota;Mission;Molecular;mouse model;Mus;mutant;National Institute of Allergy and Infectious Disease;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Patients;Population;Public Health;Reproduction spores;Research;Risk;Structure;Surface;System;Testing;Therapeutic;therapy design;therapy development;Toxin;Transcript;transcriptome;Vertebrates;Virulence

PROJECT_TITLE: Contact-dependent suppression of Clostridioides difficile sporulation by enterococci

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Data Science;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Orphan Drug;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Drug repurposing has emerged as an important therapeutic strategy in the context of rare genetic diseases. Due to the mostly inhibitory nature of existing drug molecules, they are most effective on genetic variants that are likely to increase a protein's function, but the identification of such variants remains an open challenge. The objective of the proposed research is to apply variant impact prediction methods and other computational approaches, on publicly available Common Fund data sets to: (1) identify disease-associated variants that increase the propensity for specific biochemical functions in proteins, and (2) identify candidate drug molecules that directly or indirectly inhibit these functions.

PI_NAMEs: PEJAVER, VIKAS RAO (contact)

PROGRAM_OFFICER_NAME: PAPANICOLAOU, GEORGE

PROJECT_TERMS: Address;Affect;Allosteric Site;Award;Base Sequence;Binding;Biochemical;Bioinformatics;biomedical data science;candidate identification;Catalytic Domain;Child;Code;computer infrastructure;Computing Methodologies;cost effective;Data;Data Set;Databases;Development;Disease;disease-causing mutation;drug candidate;drug development;drug repurposing;Drug Targeting;Environment;Enzymes;FDA approved;Foundations;Funding;Future;gain of function;gain of function mutation;Genetic Diseases;genetic variant;Genome;genomic data;Genomics;glycosylation;Government;Home;human disease;in silico;Incentives;inhibitor;innovation;knowledgebase;Lead;Libraries;Link;loss of function;Machine Learning;machine learning model;Measurable;Measures;medical schools;Mendelian disorder;Methodology;Methods;Mining;Molecular;Molecular Biology;Mutation;Nature;Network-based;novel;novel therapeutics;open source;Orphan Drugs;Outcome;Pathogenicity;Pharmaceutical Preparations;Pilot Projects;Positioning Attribute;Post-Translational Modification Alteration;Post-Translational Modification Site;Principal Investigator;programs;Property;protein function;protein structure;Proteins;Rare Diseases;rare genetic disorder;Research;Research Personnel;Resources;Role;Site;Source Code;Techniques;Testing;Therapeutic;tool;Training;Validation;validation studies;Variant;Work

PROJECT_TITLE: Variant impact prediction on Common Fund data sets towards drug repurposing for rare genetic diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (50)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Childhood Injury;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE This proposal hypothesizes that chronic hypoxia leads to metabolic and epigenetic disruption in the developing brain, which contributes to long-term functional dysfunction. Using advanced imaging and multi-omic studies, we propose two aims: to test if there is a correlation between placental metabolic dysfunction and brain metabolic dysfunction from chronic hypoxia and if cortical metabolic dysfunction from chronic hypoxia correlates with transcriptomic and epigenetic disruption in the developing cortex. The findings from this study could provide a framework for understanding the complex multi-system dynamics that impact the effect of prenatal insults on neurodevelopment.

PI_NAMEs: CRISTANCHO, ANA  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Affect;alcohol exposure;Animals;Bioenergetics;body volume;Brain;Brain Injuries;brain metabolism;brain volume;Categories;Cell Nucleus;cell type;Chromatin;Chronic;Clinical;Collaborations;Complex;Conceptions;congenital heart abnormality;Data;Diabetes Mellitus;disability;disease model;DNA Methylation;dynamic system;Embryo;Energy Metabolism;Energy Metabolism Pathway;Epigenetic Process;epigenetic regulation;epigenome;excitatory neuron;experimental study;Exposure to;fetal;Fetus;Functional disorder;Functional Imaging;Genetic Transcription;Gestational Diabetes;Growth;Harvest;Histone Acetylation;histone methylation;Hypertension;Hypoxia;Hypoxic Brain Damage;Image;improved;in utero;Individual;Injury;innovation;insight;irradiation;Joints;Laboratories;Learning Disabilities;Link;Magnetic Resonance Imaging;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;metabolic imaging;Metabolism;Mitochondria;Modeling;Modification;Molecular;molecular phenotype;Molecular Profiling;multiple omics;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neuroprotection;Neurosciences;non-invasive imaging;normoxia;novel;offspring;Outcome;Oxygen;Pathology;Pattern;Placenta;Placental Biology;Placental Insufficiency;Predisposition;Pregnancy;pregnancy hypertension;pregnant;prenatal;prenatal exposure;Prenatal Injuries;Qualifying;resilience;response;Risk;Rodent Model;Severities;Structural defect;Structure;Techniques;Technology;Testing;Time;tool;transcriptome;transcriptomics;Uterus

PROJECT_TITLE: Molecular and bioenergetic dynamics of in utero chronic hypoxia on placenta and brain

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Genetics;Neurosciences;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH STATEMENT  Chronic alcohol drinking is associated with development of alcohol dependence, but the specific molecular mechanisms by which alcohol-induced brain changes lead to alcohol use disorder have yet to be fully elucidated. We propose to develop a rodent preclinical model with which to advance our understanding of the molecular and cellular changes associated with alcohol exposure and test the feasibility of biomarker development for early detection of alcohol-induced neuropathology.

PI_NAMEs: KIM, YONG  (contact);SPIGELMAN, IGOR

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: addiction;Address;Adopted;Affect;Alcohol dependence;alcohol effect;alcohol exposure;alcohol research;alcohol testing;alcohol use disorder;Alcohols;Applications Grants;Astrocytes;Axon;Biogenesis;Biological Markers;Biological Process;biomarker development;Blood;Blood - brain barrier anatomy;Brain;brain cell;Brain Injuries;Brain Neoplasms;Brain region;Breeding;Cell Communication;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Chronic;chronic alcohol ingestion;Collection;Communication;Communities;Complex;Confocal Microscopy;Dependence;design;Detection;Development;diagnostic biomarker;diagnostic tool;Disease;Drug Addiction;drug of abuse;Early Diagnosis;Environmental Risk Factor;Ethanol;exosome;Exposure to;extracellular vesicles;feasibility testing;Functional disorder;Genetic;genetic information;Genetic Recombination;Goals;Health;Heavy Drinking;Immunohistochemistry;in vivo Model;insight;intercellular communication;Liver;Maintenance;Mediating;Mediator;microvesicles;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Nervous System Physiology;Neuroglia;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;neurotransmission;Oligodendroglia;Pathogenesis;Pathologic;Pathway interactions;Patients;Physiological;Plasma;Play;Pre-Clinical Model;preservation;Process;Public Health;Reporter;Research;RNA;Rodent;Role;Serum;sex;Substance Use Disorder;Synaptic Transmission;Techniques;Therapeutic;trafficking;transcriptome sequencing;transcriptomics;Transgenic Organisms;Validation;vapor

PROJECT_TITLE: Chronic alcohol effects on the biogenesis, distribution, and RNA content of astrocytic exosomes

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative This multi-project grant focuses on the causes of severe respiratory tract inflammation that leads to asthma and chronic rhinosinusitis, two closely related, common and debilitating conditions. The knowledge gained should lead to improved diagnostic and treatment options.

PI_NAMEs: BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Airway Disease;airway inflammation;airway remodeling;Allergic Disease;Animals;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Basal Cell;Cell Aging;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Cholesterol Homeostasis;chronic rhinosinusitis;Clinical;Clinical effectiveness;clinical efficacy;Clinical Trials;Collaborations;comparative efficacy;Controlled Clinical Trials;cysteinyl-leukotriene;Cytokine Signaling;Development;Diagnostic;Dinoprostone;Disease;Double-Blind Method;Dysplasia;Effector Cell;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Failure;FRAP1 gene;Functional disorder;Funding;Genetic Transcription;Genomics;Grant;Homeostasis;IL6ST gene;Immune;immunopathology;Impairment;imprint;improved;Individual;Inflammatory;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Interleukin-6;Interleukins;Knowledge;leukemia;LIF gene;Link;Maintenance;Maps;mast cell;mastocytosis;Mediator;Molecular;Nasal Polyps;Nose;notch protein;novel;Pathology;Pharmaceutical Preparations;Phenotype;Placebo Control;placebo controlled trial;polyposis;Population;pressure;Production;programs;Proliferating;Prostaglandin Production;recruit;Recurrence;Research;Research Personnel;respiratory;Respiratory System;restoration;restraint;Role;Signal Transduction;skills;stem cells;Stromal Cells;Syndrome;Testing;Therapeutic;Tissues

PROJECT_TITLE: Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease


NIH_SPENDING_CATS: Asthma;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: BARRETT, NORA AMANDA (contact)

PROGRAM_OFFICER_NAME: DAVIDSON, WENDY F

PROJECT_TERMS: Airway Disease;airway epithelium;airway inflammation;aspirin-exacerbated respiratory disease;Asthma;Automobile Driving;Basal Cell;beta-Galactosidase;Biological Assay;Bronchiectasis;Cell Adhesion Molecules;Cell Aging;Cell Differentiation process;Cell Physiology;Cellular Assay;Cellular Metabolic Process;Chromatin Structure;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Communities;cytokine;Data;Development;Dinoprostone;Disease;Dysplasia;Eczema;Eosinophilic Esophagitis;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Failure;FDA approved;Food Hypersensitivity;FRAP1 gene;Funding;Generations;Genes;genetic signature;Genetic Transcription;genome wide association study;Goals;Homeostasis;Human;Hypertrophy;Immune;immunopathology;imprint;Inflammatory;Interleukin 4 Receptor;Interleukin-13;Interleukin-4;Interleukins;Interruption;long-term sequelae;Maintenance;Mediator;Metabolic;Metabolic Pathway;Metabolism;Molecular;mouse model;Mus;Nasal Polyps;Nose;Pathogenesis;Pathway interactions;Patients;polyposis;Polyps;prevent;programs;Proliferating;Recurrent disease;Relapse;Reporting;Research;Resources;respiratory;response;restraint;Role;senescence;Signal Transduction;Site;stem;stem cell function;stem cell population;stem cells;Therapeutic;Tissues;Transcript;transcriptomics;TSLP gene;wound healing

PROJECT_TITLE: Project 2. Basal Cell Dysplasia in Type 2 Immunopathology


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Infectious Diseases;Pediatric;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on investigating differences in immune mechanisms of myocarditis development between pediatric and adult populations. Myocarditis caused by viral infections is a leading cause of sudden death in children and young adults, but it is understudied, especially in children. There is a critical need to understand better the mechanisms of myocarditis in order to improve diagnosis and prevent progression to chronic heart failure and death; thus, this project is related to the NIH mission of lengthening life and reducing illness, especially in vulnerable populations.

PI_NAMEs: BRUNO, KATELYN ANN (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acute Myocarditis;adaptive immune response;Adult;Affect;Age;age difference;age related;aged;Aging;Andropause;Animal Model;Antibody Response;Autoimmune Diseases;Autopsy;Blood specimen;Cardiac Myocytes;Cardiovascular system;Cause of Death;Cells;Cessation of life;Child;Childhood;Clinical;Clinical Data;Complement;Congestive Heart Failure;COVID-19 patient;Coxsackie Viruses;Data;Development;Diagnosis;Dilated Cardiomyopathy;Disease;Elderly;Enterovirus;Estrogens;Etiology;Female;Functional disorder;Goals;Gonadal Steroid Hormones;Heart;Heart failure;heart function;Heart Transplantation;Hormones;Immune;immune activation;Immune response;Immunologic Markers;improved;Incidence;Infant;Infection;Infectious Agent;Inflammasome;Inflammation;Inflammatory;Innate Immune Response;innovation;Knowledge;Laboratories;Life;life span;Literature;male;Menopause;Mission;Modeling;mouse model;Mus;Myocardial;Myocarditis;Myocardium;Necrosis;Newborn Infant;old mice;Outcome;ovarian failure;Pathway interactions;Patient Care;Patients;pediatric patients;personalized approach;Population;predictive marker;prevent;Puberty;Public Health;Reporting;Research;response;Role;Severities;Severity of illness;sex;Sex Differences;specific biomarkers;Sudden Death;Testing;Testosterone;Therapeutic;United States National Institutes of Health;vascular inflammation;viral myocarditis;Virus Diseases;Vulnerable Populations;young adult

PROJECT_TITLE: Elucidating the innate and adaptive immune mechanism differences during viral myocarditis between pediatric and adult populations: role of sex, age and hormone status

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Narrative Motor function is often compromised as part of the normal healthy aging process or due to acute neurological insult, such as stroke and spinal cord injury. This project is expected to demonstrate that when the sensory afferent vagus nerve is stimulated noninvasively during motor training, motor skill improvement is enhanced in healthy older adults. The expected findings will be the foundation for opening new research directions, tool development, and applications to rehabilitation for various populations with movement disorders.

PI_NAMEs: SHINOHARA, MINORU  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acetylcholine;Acute;Adopted;Adult;Age;age related decline;aged;Aging;aging process;Animal Experimentation;Animals;Biological Markers;Body part;Brain;Central Nervous System;Chest;Clinical;Clinical Research;clinically significant;cognitive neuroscience;Control Groups;Dance Therapy;Deterioration;Development;Devices;disabled;Dopamine;Dyskinetic syndrome;Ear;effective intervention;efficacy testing;Electrodes;Essential Tremor;exercise rehabilitation;Fingers;Foundations;Future;Grant;healthy aging;Human;Implantation procedure;improved;Individual;Intervention;Knowledge;Learning;Limb structure;Link;locus ceruleus structure;Measures;Motion;Motor;motor control;Motor Cortex;motor function improvement;motor learning;motor recovery;Motor Skills;Movement Disorders;Mus;Neck;Nervous System Trauma;Neurologic;neuromechanism;neuroregulation;neurotransmission;Neurotransmitters;Norepinephrine;older adult;Organ;Paper;Parkinson Disease;Participant;Patients;Performance;Population;Procedures;Psychological reinforcement;Publications;Publishing;Pupil;Quality of life;Randomized;Rattus;Rehabilitation therapy;Research;response;Rest;Rewards;Risk;Rodent;Sensory;Signal Transduction;skills;skills training;spasticity;Spinal cord injury;Spinocerebellar Ataxias;statistics;Stroke;success;Surface;System;Testing;Time;tool development;Tragus;Training;Translating;Tremor;Up-Regulation;vagus nerve stimulation;Vagus nerve structure;wearable sensor technology;young adult

PROJECT_TITLE: Pairing tVNS with motor skill training in older adults

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Impaired ability to respond to the earth’s gravitational field results in falls with adverse consequences to health, quality of life, and health care costs. This risk of falling is a particularly major issue for elderly individuals and those with neurodegenerative diseases. To understand the mechanism of gravity sensing at the molecular and neural circuit level and thus set the stage for the development of novel therapeutics to reduce falls, we propose using the simple yet experimentally powerful microscopic nematode Caenorhabditis elegans.

PI_NAMEs: BAU, HAIM H;RAIZEN, DAVID MENASSAH (contact)

PROJECT_TERMS: adverse outcome;Afferent Neurons;aging population;Animal Testing;Animals;Bathing;Behavior;Biological Assay;Caenorhabditis elegans;candidate identification;Carboxy-Lyases;Chloride Channels;Cilia;Data;density;Development;Dopamine;Dopamine Receptor;dopaminergic neuron;economic cost;Elderly;Elements;epithelial Na+ channel;equilibration disorder;Equilibrium;Experimental Genetics;experimental study;fall risk;falls;Family;Family member;fear of falling;Felis catus;Fluorescent Probes;Force of Gravity;Funding Mechanisms;Future;Genes;Genetic;genetic manipulation;Genetic Screening;Glutamate Decarboxylase;Glutamate Transporter;Glutamates;Goals;Gravity Perception;Health;Health Care Costs;high risk;Histamine;Human;Hydroxylation;Impairment;Individual;Ion Channel;Mechanoreceptors;Mediating;Medical Economics;member;Microscopic;Mobility decline;Molecular;Motility;mutant;Mutation;Nematoda;Nervous System;neural;neural circuit;neurochemistry;Neurodegenerative Disorders;Neurons;Neurotransmitters;novel;novel therapeutics;Octopamine;optogenetics;Parkinson Disease;Perception;Pharmacology;Phylogenetic Analysis;Piezo 2 ion channel;Planet Earth;promoter;Proteins;Quality of life;response;reverse genetics;Risk;Role;sensory mechanism;Serotonin;Societies;socioeconomics;Sorting;Structure;Swimming;Synaptic Transmission;System;Testing;tool;Touch sensation;Toxin;Tryptophan;Tyramine;Tyrosine 3-Monooxygenase;Vertebrates;Work

PROJECT_TITLE: Identifying molecular mechanisms of responding to gravity using the nematode C. elegans

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE We propose to examine multi-directional tuning of head orientation in navigating rats. This project will determine how the brain learns and encodes transitions between headings within a complex network of pathways. The findings will be relevant to understanding of learning and memory processes in the hippocampal and subicular systems and in neurological disorders.

PI_NAMEs: NITZ, DOUGLAS ARTHUR (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Behavioral and circuit manipulations of directional tuning in Subiculum

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: NARRATIVE  The present study explores the role of long non-coding RNAs (lncRNAs) in the ovulatory process. We have discovered a number of lncRNA transcripts that were highly regulated by hCG (LH-analog) prior to ovulation in mice, however, nothing is known about their function in the ovulatory process. Hence, the proposed studies will investigate the role of the most highly LH/hCG-regulated ovarian lncRNAs associated with the processes of follicular rupture and oocyte release, which will aid in the understanding of the regulation of human fertility.

PI_NAMEs: SHRESTHA, KETAN  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acetylation;Affect;Age;Anovulation;Apoptosis;Biological Assay;Candidate Disease Gene;Cell Cycle;Cell Physiology;Cells;Code;Collecting Cell;Collection;Complex;Contraceptive Agents;Contraceptive methods;Cyclin-Dependent Kinase Inhibitor 2A;Data;Defect;differential expression;DNA;experience;Female;female fertility;Female infertility;Fertility;Foundations;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;granulosa cell;hormone analog;Human;Human Chorionic Gonadotropin;improved;improved outcome;Infertility;infertility treatment;inhibitor;innovation;Junk DNA;knock-down;Knock-out;Liver;Luteinizing Hormone;Measures;Mediator;Methylation;mouse model;Mus;Noise;novel;Nucleotides;oligo ovulation;Oocytes;Ovarian;Ovary;Ovulation;Ovulation Inhibition;Pathway interactions;Personal Satisfaction;Phosphorylation;Play;Polycystic Ovary Syndrome;Post-Translational Protein Processing;Premature Ovarian Failure;Process;Proteins;Regulation;Reporting;reproductive;reproductive success;Research Technics;Residual state;RNA;RNA Sequences;Role;Rupture;Small Interfering RNA;Sterility;Structure;Techniques;Testing;Time;Tissues;Transcript;transcription factor;transcriptome sequencing;Ubiquitination;Untranslated RNA;Woman;women's diagnosis;women's reproductive health

PROJECT_TITLE: Role of Long Non-coding RNAs in the Ovulatory Process

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH NARRATIVE To address the significant yet often overlooked problem of HIV among cisgender women, we will adapt and test a multilingual technology-based strategy supporting informed decision-making for PrEP in primary care.

PI_NAMEs: PACK, ALLISON  (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adoption;Adult women;Affect;AIDS prevention;Algorithms;Area;arm;attentional control;Awareness;Bisexual;black women;Chicago;cis-female;Clinic;clinical decision support;Clinical Practice Guideline;community advisory board;community collaboration;condoms;cooking;Counseling;County;Data;Decision Making;Dedications;Diagnosis;Education;Educational Materials;efficacy testing;Electronic Health Record;empowerment;English Language;Epidemic;Equity;evidence base;experience;Feedback;Female;Foundations;Future;Gays;Health;health literacy;Healthcare;Hepatitis C;Heterosexuals;Hispanic Women;HIV;HIV Infections;HIV risk;improved;Individual;Infection;innovation;Intention;intimate partner violence;Intramuscular Injections;Knowledge;Language;low health literacy;Maintenance;marginalized population;Measures;Mediation;men;Methods;multi-site trial;Multilingualism;Multimedia;patient oriented;patient portal;Patient Preferences;Patients;Persons;pill;pilot test;Positioning Attribute;pre-exposure prophylaxis;preference;prevent;Primary Care;primary care clinic;primary care provider;Printing;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Resources;response;Risk Factors;Schedule;Secure;sex;sexually active;Sexually Transmitted Diseases;social stigma;Spanish;Standardization;substance use;Technology;telehealth;Testing;Time;tool;Training;Translations;transmission process;United States;United States Public Health Service;uptake;Visit;Woman;women of color;women's prevention;Work

PROJECT_TITLE: Encouraging Multiple PrEP Options for Women Engaged in PRimary Care (EMPOWER)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-H (50)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Digestive Diseases;Genetics;Liver Disease;Organ Transplantation;Patient Safety;Precision Medicine;Prevention;Transplantation

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE We will investigate whether expression data from serum-derived extracellular vesicles can be used to predict the in vivo pharmacokinetics of the CYP3A4/5 substrate tacrolimus. Using a multi- pronged strategy, we will integrate pharmacokinetics, liquid biopsy technology, genotyping, and activity data to propose individualized doses, based on the individual expression of hepatic and gut enzymes. Data will be integrated into model-informed Bayesian estimation tool to guide individual tacrolimus dosing in post-liver transplant patients.

PI_NAMEs: DE MORAES, NATALIA VALADARES (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: ABCB1 gene;Acceleration;Acute;Adrenal Glands;Adverse reactions;Affect;Biological Markers;Blood;Calcineurin inhibitor;Clinical;Clinical Research;CYP3A4 gene;CYP3A5 gene;cytokine;Data;design;Disease;Dose;dose individualization;Down-Regulation;drug development;Drug Kinetics;drug market;Drug Monitoring;Drug toxicity;Ensure;Enzymes;Exclusion;experimental study;extracellular vesicles;Genetic;Genetic Polymorphism;genetic signature;genetic variant;Genotype;Heart;Hepatic;Hepatocyte;Human;Immunosuppressive Agents;improved;in vitro activity;in vivo;Individual;Infection;Inflammation;Inflammatory;Injury;innovation;Intervention;Intestines;Kidney;Link;liquid biopsy;Liver;liver transplantation;Lung;Maps;mathematical model;Modeling;models and simulation;Organ;organ transplant recipient;organ transplant rejection;Organ Transplantation;Pancreas;Patients;Performance;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;pharmacokinetic model;phenotypic biomarker;Plasma;Population;precision medicine;prevent;prospective;Proteomics;public health intervention;Regimen;Research;Risk;Risk Reduction;Role;Sampling;Serum;side effect;Solid;Source;Spleen;Subgroup;Tacrolimus;Technology;Testing;Therapeutic;Therapeutic immunosuppression;Time;Tissue Sample;Tissues;tool;Traction;Transcriptional Regulation;transcriptomics;Translating;Transplant Recipients;Transplantation;Underrepresented Populations;Variant

PROJECT_TITLE: Liquid biopsy technology towards individualized immunosuppression therapy

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Primary Health Care;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This study will evaluate the impact of the OpenNotes policy on clinical documentation in two specialties: mental health and primary care in the United States using a computational analysis with natural language processing (NLP) tools. We will identify shifts in the medical record language pre and post the policy implementation with a focus on aspects related to the accessibility and readability of the note, how specific it is, any changes in the provider socio- emotional tone, and how sensitive topics and stigmatizing language shifted. Furthermore, we will study the impact of OpenNotes on health disparities and the use of stigmatizing language and how these aspects can lessen or inase the gap of disparities.

PI_NAMEs: ZIRIKLY, AYAH  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Accountability;Affect;Anxiety;Area;Behavioral Medicine;Caring;Clinical;Communication;Computer Analysis;Computerized Medical Record;computerized tools;cost;demographics;Disparity;disparity gap;Documentation;Domestic Violence;Emotional;experience;Future;health care disparity;health disparity;Healthcare;Improve Access;improved;Language;Measures;Medical;Medical Education;Medical Records;medical specialties;Mental Health;Mental Health Services;Minority Groups;Natural Language Processing;Nature;open source library;Patient Care;Patient Self-Report;patient subsets;Patients;Pattern;Perception;Policies;Population;Primary Care;programs;Provider;Reaction;Readability;Reading;Records;Report (document);Research;Stigmatization;Structure;Substance abuse problem;substance misuse;Surveys;System;Terminology;tool;Training;United States;Work

PROJECT_TITLE: How Do OpenNotes Policies Affect Healthcare Disparities? A Computational Approach


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Immunization;Infectious Diseases;Infertility;Prevention;Sexually Transmitted Infections;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Vaccine Related;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE Chlamydia trachomatis sexually transmitted infection poses critical threats to women’s reproductive health. Our proposed study aims to characterize the early immune responses to Chlamydia infection in the female reproductive tract, and identify major cellular components and their effector functions essential for protective immunity and development of immunopathology. These studies are important for fundamental understanding of host innate immunity to Chlamydia, and will aid the design of a protective Chlamydia vaccine.

PI_NAMEs: LI, LIN-XI  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: adaptive immunity;Age;Bacteria;BCG Live;BCG Vaccine;Bone Marrow;CD4 Positive T Lymphocytes;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;chlamydia vaccine;combat;Consensus;Data;Defense Mechanisms;design;Development;Disease;Ectopic Pregnancy;Epigenetic Process;female reproductive tract;female reproductive tract infection;Future;Gene Expression;Generations;Heterogeneity;Human;Immune;Immune response;Immunity;Immunologic Memory;Immunology;immunopathology;in vivo;Infection;Infection prevention;Infertility;Infiltration;Intravenous;intravenous injection;Kinetics;Licensing;Lymphocyte;Macrophage;Maps;Measures;Memory;Metabolic;monocyte;mouse model;Mucous Membrane;Multipotent Stem Cells;Mus;Myeloid Cells;Myeloid Progenitor Cells;Myelopoiesis;Natural Immunity;novel;Outcome;pathogen exposure;Pathologic;Pelvic Inflammatory Disease;permissiveness;Phase;Phase I Clinical Trials;Phenotype;Population;prevent;Preventive vaccine;Production;prophylactic;Rag1 Mouse;Reporter;Reporting;Research;response;Role;Safety;secondary infection;Serum;Sexually Transmitted Diseases;single-cell RNA sequencing;Source;Subunit Vaccines;success;synergism;Training;United States;vaccine access;vaccine candidate;vaccine development;vaccine strategy;Vaccines;virtual;women's outcomes;women's reproductive health;Work;young woman

PROJECT_TITLE: Exploring early protective immune responses to Chlamydia

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Phospholipase C (PLC) enzymes increase cytoplasmic calcium levels in response to diverse hormonal signals, but how they are regulated and how they interact with biological membranes where their substrate is located remains poorly understood. In this proposal, we will use single molecule studies, cryo-electron microscopy, and cell-based functional studies to investigate how heterotrimeric G proteins and the membrane coregulate PLCb. This work is expected to reveal novel regulatory features that could be exploited to develop new strategies for the treatment of cardiovascular disease, cancer, and opioid addiction.

PI_NAMEs: LYON, ANGELINE MARIE (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Active Sites;addiction;Address;alpha helix;Behavior;behavior change;Binding;Binding Proteins;Biological;Biological Assay;Bioluminescence;C-terminal;Calcium;cancer addiction;Cardiac;Cardiovascular Diseases;Catalytic Domain;Cell membrane;Cell Proliferation;Cell Survival;Cells;Chemicals;Chemotaxis;Complex;confocal imaging;Coupled;Cryoelectron Microscopy;Cytoplasm;Data;Development;Distal;Elements;Energy Transfer;Enzymes;extracellular;Family;Fluorescence Microscopy;Goals;GTP-Binding Proteins;Heart Diseases;Heart failure;Heart Hypertrophy;Heterotrimeric G Protein Subunit;Heterotrimeric GTP-Binding Proteins;hormonal signals;Hydrolysis;Hyperalgesia;Individual;insight;interfacial;Isoenzymes;Kinetics;Lipase;Lipid Bilayers;Liposomes;Location;Malignant Neoplasms;Measures;Membrane;membrane model;Microscopy;Modeling;Molecular;Molecular Conformation;Monitor;Muscle Contraction;novel;novel therapeutic intervention;Opiate Addiction;Opioid;particle;Phosphatidylinositol 4,5-Diphosphate;Phospholipase;Phospholipase C;phospholipase C beta;Play;Process;Proliferating;protein activation;Protein Isoforms;Protein Kinase C;receptor;reconstruction;recruit;Regulation;Regulatory Element;response;Roentgen Rays;Role;Second Messenger Systems;Signal Transduction;single molecule;Site;Structure;Surface;Testing;Therapeutic;Time;Vascular Smooth Muscle;Work

PROJECT_TITLE: Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteins

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative We propose to study the transcriptional control of the innate-like natural killer T cells (NKT cells). We will examine how the transcription factor, PLZF, which controls the functions of these cells is regulated by a co-factor protein. In this application, we will combine sophisticated cellular, molecular and biochemical approaches that will give insight into how these cells are controlled and how they contribute to a wide range of immune responses.

PI_NAMEs: SANT'ANGELO, DEREK B. (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Affinity Chromatography;Area;ATAC-seq;B-Lymphocytes;Binding;Binding Sites;Biochemical;Biological Process;biological systems;CD8-Positive T-Lymphocytes;Cell Lineage;Cell Physiology;cell type;Cells;Chromatin;Chromatin Loop;Chromatin Modeling;chromatin modification;cofactor;Complex;Cytotoxic T-Lymphocytes;Data;Development;DNA;DNA Binding;experimental study;Family;Family member;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Helper-Inducer T-Lymphocyte;Immune response;Immune system;immune system function;immunoregulation;innovation;insight;Interleukin-10;intestinal homeostasis;Knowledge;Learning;Lymphocyte;Lymphocyte Function;Lymphocyte Subset;Mass Spectrum Analysis;member;Molecular;Natural Killer Cells;Overlapping Genes;Phase;Phenotype;Play;Polycomb;protein complex;Protein Family;Proteins;Regulation;Regulatory T-Lymphocyte;response;Role;Structure of germinal center of lymph node;Systems Development;Testing;transcription factor;Transcriptional Regulation;Virus;YY1 Transcription Factor;ZNF145 gene

PROJECT_TITLE: The BTB-ZF transcription factor, PLZF, requires YY1 to function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HANOVER

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Evidence from this project will elucidate how experiencing housing instability over one’s lifetime can lead to worse health and disease later in life. Knowledge of how the negative consequences of housing instability for cognitive functioning, psychological distress, self-rated health, and functional limitations contribute to persistent racial/ethnic health disparities at older ages stresses to policymakers and health professionals the need for bridging housing policy with public health to meet the basic needs of disadvantaged, underserved individuals and communities.

PI_NAMEs: SHARP, GREGORY K (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adult;Black Populations;Black race;black/white disparity;Buffers;Chronic;cognitive function;cost;Coupled;COVID-19 pandemic;Data;design;Disadvantaged;Disease;disorder risk;Disparity;ethnic disparity;ethnic health disparity;Ethnic Origin;Ethnic Population;Etiology;expectation;experience;Exposure to;Extended Family;Family dynamics;Financial Hardship;Foreclosure;Health;health disparity;Health Professional;Home;Homelessness;Household;Housing;housing instability;human old age (65+);Impairment;Inequality;innovation;Intervention;Knowledge;late life;Latino;Life;life span;Long-Term Effects;Maps;Mediating;Mental Health;Modeling;novel;older adult;Outcome;Ownership;panel study of income dynamics;people of color;Personal Satisfaction;physical conditioning;Policies;Policy Maker;prevent;Probability;Process;psychological distress;Psychosocial Stress;Public Health;Race;racial disparity;racial health disparity;racial population;Research;residential tenure;Resources;response;Rest;Risk;Role;Selection Bias;Shock;social health determinants;socioeconomics;Source;spelling;Stress;Stressful Event;Structural Models;System;Techniques;Theoretical model;Time;underserved community;Underserved Population;Weight;Work

PROJECT_TITLE: Racial/Ethnic Disparities in Housing Instability, Extended Kin Resources, and Late-Life Health

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Hidradenitis suppurativa (HS) is chronic inflammatory skin disease characterized by painful lesions in areas of skin folds and affects approximately 1% of the population, predominantly women and African Americans. A better understanding of HS pathogenesis is needed to develop novel treatment strategies that will improve quality of life in those living with this devastating disease. Here we will study the role of antibodies in the disease pathogenesis so that knowledge gained from these studies could be used identify novel therapeutic strategies to reduce pain and suffering.

PI_NAMEs: JACOB, JOSHY  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Abscess;adalimumab;Affect;Affinity;African American population;Age;American;Anogenital region;Antibodies;Antibody Affinity;Antibody Specificity;Antigen Targeting;Antigens;Area;Atlases;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoreactivity;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Blocking Antibodies;Cells;Cellular biology;Chronic;chronic inflammatory skin;Cicatrix;Clinic;Clonality;cohort;completed suicide;Country;Cross Reactions;Data;Dermatologist;Deuterium;Disease;Enzyme-Linked Immunosorbent Assay;Epitopes;Epstein-Barr Virus Infections;Exhibits;FDA approved;Freezing;Future;gammaherpesvirus;General Population;Genes;Germ Lines;Grant;Hidradenitis Suppurativa;High-Income Populations;Human;Human Herpesvirus 4;human monoclonal antibodies;Hydrogen;Immune;Immunoglobulin Class Switching;Immunologist;Impairment;improved;In Situ;Individual;Inflammatory;Inguinal region;Knowledge;Lesion;Light;Link;Longitudinal Studies;Maps;Mass Spectrum Analysis;medical specialties;Molecular Mimicry;Monoclonal Antibodies;Multiple Sclerosis;Mutate;Mutation;new technology;novel;novel therapeutic intervention;Operative Surgical Procedures;opioid use;Pain;pain reduction;Pathogenesis;Pathology;Patients;Persistent pain;Phylogenetic Analysis;plasma cell differentiation;Plasma Cells;Play;Population;Proliferating;Protein Fragment;Protein Isoforms;Protein Microchips;Proteins;Proteome;Punch Biopsy;Quality of life;Race;recruit;Recurrence;response;Rheumatoid Arthritis;Risk;Role;Sampling;Screening procedure;Serum;Severities;Severity of illness;sex;Skin;skin disorder;skin lesion;Somatic Mutation;Specificity;Stains;success;suicidal risk;Systemic Lupus Erythematosus;Testing;Therapeutic;Time;treatment strategy;Trees;Variant;Viral;Viral Antigens;Viral Proteins;Virus;Virus Diseases;Woman;Work

PROJECT_TITLE: Antigen specificity of plasma cells in Hidradenitis suppurativa skin lesions

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative The current proposal asks how a specific aspect of infant’s experiences - speech from young children – shapes language development, using both in-lab tasks, naturalistic play sessions, and longitudinal assessments of vocabulary development. Using naturalistic observational data alongside experimental methods, the proposed research provides critical new insights into how speech from young children is attended to and processed by infants, and whether that speech differs systematically in content relative to speech produced by adult caregivers. The results of this multi-method approach will allow for a better understanding of why infants with older siblings have been found to have slower language development, which can readily be applied to educational or clinical settings.

PI_NAMEs: BULGARELLI, FEDERICA  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 5 year old;Accent;Acoustics;Adult;Arousal;Caregivers;caregiving;Categories;Censuses;Child;Child Care;Child Language;Clinical;Comprehension;cost;Data;Day Care;Development;Education;evidence base;experience;Exposure to;Frequencies;Genetic Transcription;Growth;Growth and Development function;Hearing;Home;Household;indexing;Individual;Infant;Infant Development;insight;Intervention;Language;language comprehension;Language Development;Learning;lexical;Linguistics;Link;low socioeconomic status;Measures;Methodology;Methods;Names;Only Child;Output;Parents;peer;Play;preference;Process;Production;Property;recruit;Research;Resources;Role;Shapes;Siblings;skills;Socioeconomic Status;Speech;Speech Perception;speech processing;speech recognition;Testing;theories;Time;Visit;Vocabulary;Work

PROJECT_TITLE: The Influence of Child-Produced Speech on Infant Language Development

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_DEPT: NEUROSCIENCES

ORG_STATE: FL

PHR: PROJECT NARRATIVE This study has the potential for significant public health impact due to the prevalence among older adults of balance and walking deficits, increased fatal and nonfatal falls, and impaired spinal cord neuronal structure and function that may affect spinal control of balance and walking. Transcutaneous spinal direct current stimulation (tsDCS) is one of the few available approaches for safe and feasible intervention of spinal circuitry that may improve spinal excitability and enhance practice-based rehabilitation of balance and walking. Successful completion of this study will provide an empirical basis for designing a novel tsDCS intervention in combination with balance exergaming, an approach that is feasible for translation into home- or community-based rehabilitation programs as a practical, cost-effective, and safe method for helping to preserve balance, walking, and independence among older adults.

PI_NAMEs: HWANG, JUNGYUN  (contact)

PROJECT_TERMS: Action Potentials;Activities of Daily Living;Acute;Address;Adjuvant;Adjuvant Therapy;adverse outcome;Affect;age effect;age related;Aging;Attenuated;Balance training;Behavior assessment;Behavioral;Brain;CD2 gene;Central Nervous System;Clinical;Combined Modality Therapy;Communities;Computer Models;cost effective;Data;design;Devices;Educational Intervention;Electric Stimulation;Electrodes;Enrollment;Equilibrium;executive function;exergame;experience;falls;Fire - disasters;Force of Gravity;functional decline;functional near infrared spectroscopy;Goals;H-Reflex;healthy aging;Home;human old age (65+);human subject protection;Impairment;improved;insight;Intervention;intervention effect;Investigation;Knowledge;Learning;Literature;Lower Extremity;Lumbar Regions;Measures;Membrane Potentials;Methods;Motor;motor deficit;motor learning;Movement;multi-component intervention;Musculoskeletal Equilibrium;neural;neuronal excitability;Neuronal Plasticity;Neurons;neuroregulation;Noise;novel;older adult;Participant;Pattern;Performance;placebo group;post intervention;Postural response;Posture;Prefrontal Cortex;preservation;Prevalence;Probability;programs;Protocols documentation;Public Health;public health priorities;Randomized;Rehabilitation therapy;Research;response;Risk;Risk Factors;Role;Sensory;Signal Transduction;skill acquisition;Skin;Soleus Muscle;Spinal;Spinal Cord;Structure;Techniques;Testing;Time;Translations;transmission process;Up-Regulation;Variant;Walking;walking performance;walking speed

PROJECT_TITLE: Upregulating spinal circuits to enhance balance and walking and to increase spinal excitability in older adults


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Overweight/obesity in children remains a leading public health concern and parents often gravitate towards using food parenting practices high in coercive control to manage their child’s obesity risk; however, these strategies are often counterproductive and lead to undesired eating and weight outcomes. Cross-sectionally, positive food parenting practices are associated with healthy child eating and weight outcomes, but less is known on whether we can successfully intervene to increase use of positive food parenting practices to help support healthy growth and diet quality in children at risk for obesity. The proposed study aims to examine the feasibility and acceptability of a positive food parenting intervention designed to prevent obesity and improve diet quality in children at risk for obesity.

PI_NAMEs: BALANTEKIN, KATHERINE NAIME (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 11 year old;Acceleration;acceptability and feasibility;Age;age group;Area;Behavior;Behavior assessment;behavior change;Body mass index;Calories;Child;Child Rearing;Competence;Consumption;cooking;coping;Data;design;Development;Diet;Disease;early childhood;Eating;Eating Behavior;Educational Curriculum;efficacy testing;efficacy trial;Enrollment;Environment;evidence base;Family;Feedback;feeding;Food;Future;Goals;Grant;Gravitation;Growth;Health;Health Food;Healthy Eating;healthy weight;improved;Individual;interest;Intervention;Laboratories;Lead;Literature;Measures;middle childhood;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obesity;obesity in children;obesity prevention;obesity risk;obesity treatment;obesogenic;Only Child;Outcome;Overweight;parenting intervention;Parents;Participant;prevent;preventive intervention;Process;programs;Public Health;Randomized, Controlled Trials;Reporting;Research;Risk Reduction;Signal Transduction;Strategic Planning;Structure;Surveys;Testing;therapy design;Time;tool;Training;Treatment Efficacy;virtual intervention;Waiting Lists;Weight;Work

PROJECT_TITLE: Positive food parenting intervention to promote healthy growth in children at risk for obesity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE This interdisciplinary project aims to unravel the mechanisms of protective mucosal innate immunity activated during respiratory virus infections. The question we address is how the inflammatory IL-6 response is poised for rapid activation by gene silencer and its noncoding RNAs when viruses invade the airway, and how this regulatory process is disrupted in the context of chronic airway remodeling observed in lung diseases like allergic asthma.

PI_NAMEs: YANG, JUN  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Abbreviations;Address;Adult;Affect;Affinity Chromatography;Age;age group;airway epithelium;airway remodeling;Anti-viral Response;antiviral immunity;Binding;Biological Assay;Cells;Characteristics;Chromatin;Chromatin Loop;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coronavirus;CRISPR interference;CRISPR/Cas technology;Data;design;Disease;DNA Polymerase II;Docking;Elderly;Enhancers;Epigenetic Process;Epithelial Cells;Epithelium;Extrinsic asthma;fighting;gain of function;Gene Activation;Genes;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;Histones;Host Defense;Human;IL6 gene;Immunoassay;Impairment;In Vitro;Inflammation;Inflammatory;Influenza A virus;insight;Interleukin-6;Invaded;Investigation;IRF1 gene;IRF3 gene;loss of function;Lung;Lung Diseases;Measures;Mediating;Mesenchymal;Methods;Mucous Membrane;Natural Immunity;negative elongation factor;next generation sequencing;NF-kappa B;novel;Nuclear;pathogen;Patients;Pattern;Play;Poly I-C;Positioning Attribute;Premature Infant;Process;Production;promoter;Proteins;Qualifying;recruit;Regulatory Element;Reporting;Research;Research Project Grants;respiratory infection virus;Respiratory syncytial virus;respiratory virus;response;Rhinovirus;Rhinovirus infection;RNA;Role;Running;Shapes;side effect;Signal Transduction;Site;skills;Structure of parenchyma of lung;Symptoms;Techniques;Testing;Therapeutic Effect;Transcription Elongation;transcription factor;Transcriptional Silencer Elements;Untranslated RNA;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Silencer-enhancer transition dysregulates interleukin-6 in mucosal epithelial cell plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-F (09)]