NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: WANG, TIAN  (contact)

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Animal Model;Animals;Behavior;Behavior assessment;behavior test;behavioral phenotyping;Biological;Body Composition;Brain;Breeding;Caring;Chronology;Clinical;Cytology;data integration;Disease;Drug or chemical Tissue Distribution;Electronics;Endocrine;Endocrinology;endophenotype;Evaluation;Female;Genotype;Goals;Health;HLA-DRB1;Human;human model;IACUC;Individual;Injury;insight;Intervention;Investigation;meetings;Midlife women;Mission;Modeling;Monitor;mouse model;Mus;mutant;National Institute on Aging;Neuroimmune system;Neurosecretory Systems;Outcome;Perimenopause;Phenotype;Physiological;prevent;Procedures;programs;Records;Regimen;Reporting;Research;Resources;risk prediction;Rodent Model;sample collection;Services;Testing;Tissue Banks;Tissue Sample;Tissues;Translating;Vagina;Weight;Woman

PROJECT_TITLE: Animal


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PORTLAND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Sex hormones are powerful regulators of gene expression, cell differentiation, and disease. We have discovered a critical role for T cell intrinsic androgen receptor activity in limiting the effectiveness of immunotherapy in prostate cancer. The goal of this proposal is to understand the mechanism(s) by which androgen receptor signaling in CD8 T cells orchestrates T cell dysfunction.

PI_NAMEs: MORAN, AMY E (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgen Response Element;androgen sensitive;Androgens;antagonist;anti-PD-L1 therapy;anti-PD1 therapy;antigen-specific T cells;ATAC-seq;Autoimmune Diseases;Binding;Biological Assay;Biopsy;Cancer Etiology;cancer immunotherapy;Cancer Model;Cancer Patient;Castration;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Chromatin;Chromatin Remodeling Factor;Chronic;Clinical Trials;Combined Modality Therapy;Complex;Disease;DNA Binding;DNA receptor;Effectiveness;effector T cell;enzalutamide;Epigenetic Process;exhaust;exhaustion;Experimental Models;experimental study;EZH2 gene;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Genomics;Goals;Gonadal Steroid Hormones;Grant;Health;histone methyltransferase;Hormones;Human;immune checkpoint blockade;Immunity;Immunosuppression;Immunotherapy;improved;In complete remission;in silico;inhibitor;Leukocytes;male;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Metastatic Prostate Cancer;mortality;mouse model;novel;novel therapeutic intervention;Oregon;Outcome;pathogen;Patients;PD-1 blockade;PD-L1 blockade;pharmacologic;Precipitation;Predisposition;programmed cell death ligand 1;programmed cell death protein 1;prostate cancer model;Prostate Sarcoma;receptor binding;Receptor Inhibition;Receptor Signaling;recruit;Regulator Genes;Repression;Resistance;response;Risk;Role;Sampling;Science;sex;Shapes;single-cell RNA sequencing;small molecule inhibitor;standard of care;synergism;T cell differentiation;T-Lymphocyte;Testing;Testosterone;Time;Transcriptional Regulation;treatment strategy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;United States;Universities;Viral;Virus;Woman

PROJECT_TITLE: Understanding how T cell intrinsic androgen receptor activity influences cell differentiation and dysfunction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth;Urologic Diseases;Women's Health Research

ORG_CITY: STANFORD

ORG_DEPT: UROLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Overactive bladder is a common, debilitating, chronic condition that affects over 33 million Americans. The impact on quality of life is significant, and access to management is often limited in vulnerable and underserved populations. Through a mixed-methods approach, the proposed research will provide a low-cost, scalable strategy to improve access and adherence to therapies, thereby improving OAB outcomes.

PI_NAMEs: ENEMCHUKWU, EKENE  (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Adherence;Affect;American;Award;barrier to care;Behavior Therapy;care seeking;Caring;Chronic;Clinical;cost;cost effective;Data;design;Development;Diagnosis;Disease;efficacy trial;empowerment;ethnic diversity;evidence base;Evidence based intervention;Evidence based treatment;expectation;Female;Funding;future implementation;Goals;Health;health care delivery;Health Personnel;Health Services Accessibility;Improve Access;improved;Increased frequency of micturition;innovation;International;Intervention;Interview;Knowledge;Lead;Low income;Methods;mHealth;mhealth interventions;micturition urgency;minimally invasive;Minority Groups;mobile application;mobile computing;multidisciplinary;Outcome;Overactive Bladder;Patient Education;patient engagement;patient expectation;patient oriented;Patients;Perception;Pharmacotherapy;Pilot Projects;pilot test;pilot trial;Population;Positioning Attribute;Procedures;Process;Provider;provider-level barriers;Publishing;Quality of life;racial diversity;Randomized;Research;Research Personnel;Risk;Role;satisfaction;side effect;social health determinants;Stigmatization;Structure;Symptoms;Syndrome;technology intervention;Testing;therapy adherence;therapy duration;therapy outcome;tool;treatment adherence;treatment as usual;Treatment Efficacy;treatment planning;Underserved Population;urinary;Urinary Incontinence;usability;Veterans;Vulnerable Populations;Woman;Women's Group

PROJECT_TITLE: Improving Overactive Bladder Treatment Access and Adherence Through Personalized Behavioral Modifications and Mobile Technology-Based Interventions

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: YIN, FEI  (contact)

PROJECT_TERMS: Address;Adipose tissue;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;American;Apolipoprotein E;apolipoprotein E-4;Bioenergetics;Biological;Brain;brain cell;cell type;Cells;Chronology;Communication;design;Endocrinology;endophenotype;Female;Genes;Genotype;Goals;Homeostasis;Immune;Immune response;In Vitro;Inflammasome;Inflammatory;Inflammatory Response;insight;Investigation;Liver;Macrophage;Mediating;meetings;Metabolic;Metabolism;metabolomics;Midlife women;Mission;mitochondrial dysfunction;Modification;National Institute on Aging;Neuroglia;Neuroimmune;Neuroimmune system;neuroinflammation;Neurons;Neurosecretory Systems;novel;Organ;Outcomes Research;Perimenopause;Peripheral;Phenotype;Plasma;prevent;programs;Regulation;Research;response;risk prediction;Role;Sampling;Shapes;Signal Transduction;single nucleus RNA-sequencing;Stress;synaptic function;T-Lymphocyte;Testing;therapeutic target;transcriptomics;Translating;Woman;Work

PROJECT_TITLE: Project 1: Metabolic Mechanisms of Perimenopausal Neuroimmune Transformation: Therapeutic Targets and Windows


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Prevention;Skin Cancer

ORG_CITY: SALT LAKE CITY

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Melanomas are pigmented skin cancers that can be difficult to distinguish from benign moles, even for trained primary physicians and dermatologists, and can be deadly if overlooked. Based upon the genes and regulatory molecules that distinguish moles from melanomas, the proposed project explores new methods for detecting and preventing the transformation of moles into melanomas.

PI_NAMEs: JUDSON-TORRES, ROBERT LAIRD (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Anatomy;Area;aurora B kinase;Automobile Driving;Benign;benign state;Biological Assay;Biological Models;Biology;Biopsy;BRAF gene;CDKN2A gene;Cell Cycle;Cells;Chemoprevention;Classification;Clinic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Cutaneous Melanoma;Data;Data Set;Dermatologist;Detection;detection method;Development;Diagnosis;diagnostic accuracy;differential expression;Disease;driver mutation;Drug Delivery Systems;Early Diagnosis;Early identification;early screening;Engineering;Environment;Event;G2/M Arrest;Genes;Genetic;Genetically Engineered Mouse;genomic profiling;Goals;Growth;high risk;high risk population;Histologic;Human;Human Engineering;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Incidence;inhibitor;innovation;Interruption;Knowledge;Lesion;Malignant - descriptor;MAP Kinase Gene;Measurement;Mediating;Mediator;melanocyte;Melanocytic nevus;Melanoma;melanoma biomarkers;melanomagenesis;Methods;MicroRNAs;miRNA expression profiling;Modeling;Mole the mammal;Molecular;Molecular Profiling;mRNA Expression;Mutation;Neoplasms;Nevi and Melanomas;Nevus;novel;novel strategies;Oncogenes;Pathologist;Patients;Physicians;Pilot Projects;Positioning Attribute;pre-clinical;prevent;Prevention;Prevention strategy;PTEN gene;Regulation;Reporting;Reproducibility;Role;Sampling;screening;senescence;Signal Transduction;Skin Cancer;skin lesion;Skin Pigmentation;Specificity;Survival Rate;System;Techniques;Testing;Training;Transcript;transcriptomic profiling;tumor;Tumor Suppressor Proteins;Validation

PROJECT_TITLE: Nevus associated microRNAs as mediators of BRAF-induced growth arrest and biomarkers of melanoma progression

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Contraception/Reproduction;Health Services;Infertility;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: ECHO (Enriching Communication skills for Health professionals in Oncofertility) provides training and skill building for Allied Health Professionals. TORCH (Trainers in Oncofertility Reproductive Communication and Health) will provide training of trainers for ECHO content.

PI_NAMEs: QUINN, GWENDOLYN P (contact);VADAPARAMPIL, SUSAN T

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;adolescent health;Adult;Area;assisted reproduction;Behavior;Bioethics;Body Image;Cancer Survivor;career networking;Caring;cohort;Communication;Contraceptive methods;Counseling;curriculum enhancement;Decision Making;Disease;E-learning;Education Projects;Educational Curriculum;Educational Status;Ethical Issues;ethnic diversity;Evaluation;Evidence based program;experience;Faculty;Fertility;fertility preservation;follow-up;Geography;hands-on learning;Health;health communication;Health education;Health Professional;improved;Individual;Infertility;Institution;interest;Knowledge;Learning;learning community;lectures;Malignant Neoplasms;Minor;Modification;Monitor;new technology;Nurses;older adult;oncofertility;Oncologist;Oncology;Online Systems;Outcome;Parents;Participant;Patients;Phase;Physician Assistants;Physicians;pilot test;Policies;Population;Positioning Attribute;practice setting;Process;Process Measure;profession allied to medicine;Professional Organizations;Prognosis;programs;Psychologist;psychosocial;Psychosocial Assessment and Care;Publications;Quality of life;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;reproductive;Reproductive Health;Reproductive Technology;Resources;Risk;Services;Sex Orientation;Sexual and Gender Minorities;sexual identity;Sexuality;skills;skills training;Social Workers;success;Surveys;Survivors;survivorship;symposium;Technology;Testing;Trainers Training;Training;Training Programs;virtual;Workplace

PROJECT_TITLE: Enriching Communication skills for Health professionals in Oncofertility and Trainers in Oncofertility Reproductive Communication and Health

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: PROJECT NARRATIVE To improve alcohol use disorder treatment, particularly through precision medicine approaches, it is imperative that alcohol use disorder etiologic mechanisms are identified and assessed in a way that is reliable and valid across diverse groups of individuals. The proposed study will use a multimethod approach to develop and validate a computerized adaptive test of alcohol use disorder etiologic mechanisms. Ultimately, the goal of this work is to establish an efficient and comprehensive assessment of mechanisms that can be used in service of determining the optimal treatment, whether behavioral, pharmacological, or both, for a given person with alcohol use disorder.

PI_NAMEs: BONESS, CASSANDRA LEE (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: addiction;Address;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol testing;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Articulation;Behavioral;Calibration;Clinical;clinical decision-making;clinical practice;cognitive control;cognitive interview;Communities;community based participatory research;community setting;comorbidity;computerized;Consultations;Data;Data Collection;Development;Diagnosis;Diagnostic;Dimensions;Discrimination;disease classification;DSM-V;Ecological momentary assessment;Emotional;Ensure;Etiology;Evaluation;evidence base;Factor Analysis;follow up assessment;follow-up;Gender;Goals;Heterogeneity;Hour;improved;improved outcome;indexing;Individual;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Interview;Laboratories;Literature;Lived experience;Manuals;Measurement;Measures;mental disorder prevention;Methods;Modeling;Modernization;Mood Disorders;multimodality;National Institute on Alcohol Abuse and Alcoholism;novel;optimal treatments;Participant;Pathology;patient population;Patient Self-Report;Persons;pharmacologic;Phenotype;Population Heterogeneity;practice setting;precision medicine;Prevention;Property;Psychometrics;Psychopathology;Public Health;Reduce health disparities;Research;Research Domain Criteria;response;Rewards;Sampling;Services;Severities;sex;Strategic Planning;Structure;substance use;Testing;theories;Time;uptake;Validation;Work;Writing

PROJECT_TITLE: Measurement and Multimethod Validation of Alcohol Use Disorder Etiologic Mechanisms

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Genetics;Immunotherapy;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Anti-Inflammatory Agents;Apolipoprotein E;apolipoprotein E-4;Autoimmune Diseases;Bioenergetics;Bioinformatics;Biological;Biology;Brain;Cells;Chronology;Complex;disease phenotype;efficacy evaluation;Endocrine;Endocrinology;endophenotype;Female;Foundations;gene network;Genetic;Genotype;Goals;Immune;Immune response;Immune system;immunomodulatory therapies;immunoregulation;Immunotherapeutic agent;insight;Maps;Medical;Medicine;meetings;Menopause;Metabolic;metabolomics;middle age;Midlife women;Mission;Mus;National Institute on Aging;neural;Neuroimmune;Neuroimmune system;Neurosecretory Systems;Outcome;Pathway interactions;Perimenopause;Pharmaceutical Preparations;Phenotype;Population;Postmenopause;pre-clinical;Precision therapeutics;Premenopause;prevent;programs;Research;response;risk prediction;Systems Biology;targeted treatment;Therapeutic;therapeutic candidate;therapeutic target;Time;transcriptome;transcriptomics;Translating;translational goal;Woman

PROJECT_TITLE: Project 2: Metabolic and Immune Systems of Biology Interactions as Initiators and Drivers of Alzheimer's Pathology in Brain: Therapeutic Targets and Windows


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Families of children with limited English proficiency (LEP) have been systematically excluded from autism spectrum disorder (ASD) research; yet they likely experience additional impediments to care compared to other minoritized families. The current application proposes the largest ever, diverse, multi-lingual national survey (n=2730) of children with ASD. The survey will validate ASD mechanistic and service use measures in 5 languages, and survey data will be used to understand language disparities in ASD service use. Qualitative and consensus methods will contextualize and give policy relevance to survey findings. Study results will inform current and future disparities reduction efforts.

PI_NAMEs: BRODER-FINGERT, SARABETH  (contact);ZUCKERMAN, KATHARINE ELIZABETH

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Acceleration;Address;adolescent with autism spectrum disorder;Advocate;Appointment;autism spectrum disorder;autistic;autistic children;barrier to care;care coordination;Caring;Child;Chinese;Collaborations;Communities;Consensus;Data;design;Diagnosis;Discrimination;Disparity;disparity reduction;Ensure;Ethnic Origin;Exclusion;experience;Face;Family;Funding;Future;Geography;Goals;Guidelines;Haitian;Health;health care disparity;Health Services Accessibility;Healthcare Systems;Hospitals;implementation science;improved;innovation;Intervention;Interview;Knowledge;Language;Limited English Proficiency;Linguistics;Measures;Mediator;Medication Errors;meetings;Methods;Minority;Multilingualism;National Institute of Mental Health;Outcome;Parents;Patients;Policies;Policy Maker;Population;Population Heterogeneity;Provider;provider factors;Qualitative Research;Race;randomized trial;Recommendation;Reporting;Research;research to practice;Resistance;School-Age Population;Series;service utilization;Services;Site;social health determinants;social stigma;Social support;Spanish;Strategic Planning;Stress;structural determinants;Surveys;System;Testing;theories;therapy development;tool;Translating;treatment disparity;treatment trial;Vietnamese

PROJECT_TITLE: Validating Measures and Unpacking Differences in Service Use for Diverse Children with Autism

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Narrative  Frontonasal dysplasia (FND), also known as median cleft face syndrome, is a large class of craniofacial birth defects that profoundly impact the form and function of the face, nose, and mouth. FND patients require multiple corrective surgeries and often suffer life-long impairment. Using novel mouse models and innovative research approaches, this project will uncover the underlying developmental and molecular mechanisms and lead to significant improvement in molecular diagnosis, genetic counseling, and treatment of patients with FND and related craniofacial disorders.

PI_NAMEs: JIANG, RULANG  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Animal Model;Anterior;Apoptosis;autosome;Bioinformatics;Biological Models;Biology;bone;Cardiac;Caring;Cartilage;Cell Differentiation process;cell fate specification;Cell Physiology;Cells;Cephalic;Cleavage Under Targets and Release Using Nuclease;Cleft Palate;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Congenital Abnormality;Connective Tissue;craniofacial;craniofacial bone;craniofacial development;craniofacial disorder;craniofacial structure;cranium;Data;Development;Developmental Biology;Ectoderm;Embryo;Etiology;Exhibits;Face;face bone structure;Family;First Pharyngeal Arch;Frontal bone structure;Frontonasal dysplasia;Frontonasal Prominence;Ganglia;Gene Expression;Gene Family;gene regulatory network;Genes;Genetic;Genetic Counseling;Genome;genome editing;homeodomain;Impairment;improved;innovation;Jaw;Lateral;loss of function mutation;malformation;Maxilla;Medial;Mediating;Microphthalmos;migration;Molecular;Molecular Diagnosis;Molecular Mechanisms of Action;Morphogenesis;mouse model;Multipotent Stem Cells;Mus;mutant;Mutant Strains Mice;Mutation;Neural Crest;Neural Crest Cell;Neuroglia;Neuronal Differentiation;Neurons;Nose;novel;Operative Surgical Procedures;Oral cavity;Orbital separation excessive;Pathogenicity;Patients;Pattern;Phenotype;Pigments;Process;Regulation;Research;Research Project Grants;Role;single-cell RNA sequencing;skeletal tissue;Specific qualifier value;stem cells;Syndrome;Tissues;transcription factor;transcriptome;TWIST1 gene;vertebrate embryos

PROJECT_TITLE: Regulation of Craniofacial Development by ALX Transcription Factors

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Health Services;Human Genome;Infectious Diseases;Kidney Disease;Machine Learning and Artificial Intelligence;Precision Medicine;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Acute kidney Injury (AKI) and chronic kidney disease (CKD) impose a significant health burden worldwide, yet there is limited understanding of the injury pathways leading to these disorders. This has hampered the development of targeted therapies. The Mount Sinai Kidney Precision Medicine Project proposal seeks to recruit a diverse cohort of 40 patients with CKD and 20 patients with AKI each year over a 5-year period into a longitudinal biorepository and database of clinical and phenotypic data.

PI_NAMEs: CAMPBELL, KIRK N;COCA, STEVEN G (contact);MELIAMBRO, KRISTIN ;NADKARNI, GIRISH NITIN

PROGRAM_OFFICER_NAME: GIPSON, DEBBIE SUE

PROJECT_TERMS: Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Aging;American;Apolipoproteins;biobank;Biological;Biological Assay;Biopsy;Blood Banks;Caring;Chronic Kidney Failure;Clinic;Clinical;Clinical Data;clinical database;Clinical Research;Coca;cohort;Communities;Community Outreach;comorbidity;Complication;Consent;Country;COVID-19;COVID-19 pandemic;COVID-19 patient;Data;Dedications;Development;Diabetes Mellitus;Diabetic Nephropathy;Dialysis procedure;Disease;Disease Marker;Disease Progression;disorder subtype;DNA;Documentation;Electronic Health Record;Enrollment;Ethicists;Ethics;ethnic diversity;ethnic minority;Ethnic Origin;exome sequencing;experience;Financial Hardship;follow-up;Future;genome sequencing;Health;Health system;Healthcare;Hemorrhage;high risk;high standard;Hospitalization;Human;human tissue;Hypertension;Image;Individual;Infrastructure;Injury;innovation;Institution;Kidney;kidney biopsy;Kidney Diseases;Kidney Transplantation;Link;machine learning algorithm;Measurement;metabolomics;minimal risk;Molecular;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;novel strategies;Obesity;Outcome;Participant;participant enrollment;Pathway interactions;patient oriented;patient population;patient retention;Patients;Phenotype;phenotypic data;Plasma;post SARS-CoV-2 infection;post-COVID-19;precision medicine;predictive tools;prognostication;programs;Proteomics;Public Health;Race;racial minority;Recontacts;recruit;Registries;Renal function;Research;Resources;response;Risk;risk prediction;risk stratification;Safety;Sampling;Services;Site;sociodemographics;Specimen;System;targeted treatment;therapeutic target;therapy development;Time;Tissues;tool;transcriptome sequencing;Urine;whole genome

PROJECT_TITLE: Mount Sinai Health System Kidney Precision Medicine Project


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Psychosis;Serious Mental Illness;Suicide;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because improved post-acute care for adults with serious mental illness has the potential to reduce rehospitalizations and wasted healthcare resources due to poor treatment engagement. Moreover, the proposed Hybrid Type 1 design aligns with NIMH’s Strategic Plan, Goal 4, as we will test the effectiveness of an innovative intervention while collecting data to support implementation.

PI_NAMEs: GAUDIANO, BRANDON A (contact);MOITRA, ETHAN

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Acute;acute care;Address;Administrator;Admission activity;Adopted;Adoption;Adult;Aftercare;Ambulatory Care;Appointment;Attitude;Behavior;Blinded;Caring;Case Manager;Chronic disability;Clinical;clinical practice;Cognitive;Communities;Continuity of Patient Care;coping;cost;Data;data dashboard;Diagnosis;Disease susceptibility;Drops;Effectiveness;effectiveness testing;effectiveness trial;effectiveness/implementation trial;Electronic Health Record;Ensure;Feeling suicidal;follow-up;Future;future implementation;Goals;Healthcare;Healthcare Systems;high risk;Hospital Moving;hospital readmission;Hospitalization;Hospitals;hybrid type 1 design;Hybrids;implementation barriers;implementation context;implementation strategy;improved;indexing;ineffective therapies;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Interview;Interviewer;Investigational Therapies;Measures;Mediating;Mediator;Mental Depression;Mental disorders;mHealth;mhealth interventions;mobile application;Modeling;Monitor;Mood Disorders;National Institute of Mental Health;novel;organizational readiness;Outcome;Outpatients;Overdose;Patient Care;patient engagement;Patient Self-Report;Patients;primary outcome;Procedures;process evaluation;programs;Promoting Action on Research Implementation in Health Services framework;psychiatric symptom;Psychopathology;psychotic;Psychotic Disorders;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Records;Recovery;Research;Resources;response;Risk;Safety;Sampling;secondary outcome;Services;severe mental illness;Severities;Speed;standard of care;Strategic Planning;Stress;Suicide;System;Target Populations;Testing;Time;Translations;treatment as usual;treatment effect;treatment risk;Update;uptake;wasting;Work

PROJECT_TITLE: Effectiveness of a multi-component mHealth intervention to improve post-hospital transitions of care for patients with SMI


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Aurora

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Saltational bursts of genomic instability represent a significant source of mutagenesis. Despite their implications for genome evolution and disease progression, the properties of these episodes, and the cellular mechanisms that contribute to their occurrence are not well understood. Our research will define critical qualities of these mutagenic events and provide a foundation for future avenues of investigation regarding how these mutagenic events contribute to the evolution of eukaryotic genomes and disease processes.

PI_NAMEs: HEASLEY, LYDIA RENE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Aneuploidy;Bioinformatics;Biological Assay;Biological Models;biological systems;Biology;cancer type;Cell Cycle;Cell division;Cell Physiology;Cells;Chromosomes;Data;Dedications;Defect;design;Detection;Development;Disease;Disease Progression;DNA Damage;DNA lesion;DNA Repair;Event;Evolution;Exhibits;experience;Failure;Foundations;Frequencies;Future;Generations;Genome;genome integrity;Genome Stability;Genomic Instability;Genomics;Heterogeneity;innovation;insight;Investigation;Kinetics;Learning;Loss of Heterozygosity;Maintenance;Malignant Neoplasms;Mammary Neoplasms;Melanoma Tumor;Methods;Microscopy;Modeling;Molecular;Mutagenesis;mutant;Mutation;National Institute of General Medical Sciences;Nature;neoplastic cell;Noise;Pathologic Mutagenesis;Pathway interactions;Phase;Predisposition;preservation;prevent;Process;programs;Property;protein function;Proteome;Research;response;Saccharomyces cerevisiae;Saccharomycetales;Scientist;single cell analysis;skills;Source;success;System;Techniques;Testing;Time;timeline;Training;Training Programs;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Properties and mechanisms of punctuated genome instability


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE The oncoprotein transcription factor MYC is overexpressed in the majority of cancers and contributes to an estimated 100,000 deaths in the USA each year. This proposal outlines a strategy to define how MYC works with its co-factor WDR5 to drive gene expression changes that establish and maintain the malignant state. Completion of this work will expose unappreciated aspects of the molecular processes that drive cancer and how these can be therapeutically blocked in tumor cells.

PI_NAMEs: TANSEY, WILLIAM PATRICK (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Attention;Automobile Driving;Avidity;Behavior;Binding;Binding Proteins;Biological;cancer cell;cancer therapy;cell growth;Cell Survival;Cells;Cessation of life;Characteristics;Chromatin;Clinic;Clinical;cofactor;Collection;CRISPR screen;Data;Development;dimer;Dimerization;Disabling;DNA;DNA Binding;DNA Sequence;drug discovery;Drug Targeting;drug-like compound;Exposure to;Family;Foundations;Frustration;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Transcription;Genome;genome integrity;genome-wide;Genomics;Goals;Grant;Heart;Human;in vivo;inhibitor;innovation;Maintenance;Malignant Neoplasms;malignant state;Metabolism;Modeling;Molecular;mouse model;MYC Family Protein;MYC gene;neoplastic cell;novel;novel therapeutics;Nuclear;Nuclear Protein;Oncogenic;Oncoproteins;overexpression;Pathway interactions;pharmacologic;Process;Proliferating;Protein Biosynthesis;Proteins;Proteomics;Proto-Oncogene Proteins c-myc;recruit;Regulatory Element;Resolution;response;Ribosomal Proteins;RNA;Role;Site;stem;Therapeutic;Time;transcription factor;transcriptomics;translation factor;tumor;Tumor Promotion;tumorigenesis;tumorigenic;United States;Work

PROJECT_TITLE: Facilitated recruitment of MYC to chromatin by interaction with WDR5


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences;Opioids;Sleep Research

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: NARRATIVE This program examines how stress changes the function of CREB and kappa-opioid receptor (KOR) systems in brain motivation circuits, and how these changes affect behavior. This line of work has provided a foundation for clinical trials of KOR antagonists to treat depression, an innovative approach which thus far shows great promise. Major goals include exploring whether alterations in CREB and KOR signaling are involved in the long- lasting pro-depressive effects that are caused by immune system activation during early brain development, a form of stress occurring widely during the COVID-19 pandemic, while examining factors that control stress susceptibility and resilience in animal models that are chosen because they use measurements and endpoints that are the same as used in humans.

PI_NAMEs: CARLEZON, WILLIAM A. (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Ablation;Address;Affect;Animal Model;Anti-Anxiety Agents;anti-depressive agents;Anxiety Disorders;Behavior;Behavioral;Biological;Body Temperature;Brain;cell type;Cells;Characteristics;Chronic stress;Clinical Trials;Cognition;Cognitive;cognitive control;Complex;COVID-19 impact;COVID-19 pandemic;CREB1 gene;Data;depressive behavior;depressive symptoms;Development;Diagnosis;Diurnal Rhythm;Dynorphins;early life stress;Electroencephalography;Equilibrium;Etiology;Event-Related Potentials;experience;Female;Foundations;Genetic Transcription;Goals;Grant;Human;human tissue;Immune;immune activation;immune function;Immune response;Immune system;improved;in vivo;Inflammation;innovation;insight;Intervention;kappa opioid receptors;Life;life span;Ligands;male;Measurement;Mediating;Mental Depression;Mental disorders;Microglia;Modeling;Molecular;Mood Disorders;Motivation;Mus;Neuroglia;Neurons;novel;Nucleus Accumbens;Opioid Antagonist;Performance;Phenotype;Play;Population;Predictive Value;Predisposition;Procedures;Process;programs;Psychiatry;Psychopathology;Rattus;receptor expression;receptor function;Receptor Signaling;Regimen;Regulation;Research;resilience;resilience factor;response;Rodent;Role;single nucleus RNA-sequencing;Sleep;Sleep Architecture;Sleep disturbances;sleep regulation;Stress;stress resilience;stressor;Symptoms;System;Task Performances;Testing;Therapeutic Effect;tool;transcription factor;Up-Regulation;virtual;Work

PROJECT_TITLE: Roles of nuleus accumbens CREB and Kappa function in depression

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: Columbus

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE Children born very premature (less than 32 weeks gestational age) have higher risks and vulnerabilities for developing behavioral problems. These behavior problems can occur as early as age 2 years and if untreated cause long term problems for the child and family. This study will test digital delivery of parent training plus coaching calls for parents of young children that were born very premature. Leveraging technology to deliver parent training and providing parents with brief, supportive coaching calls represent sustainable and feasible methods to deliver empirically supported parent training to improve social, emotional, and behavioral outcomes in these young children.

PI_NAMEs: BREITENSTEIN, SUSAN M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 2 year old;acceptability and feasibility;active control;Address;Adolescence;Adult;Age;aged;Aggressive behavior;Area;Attention;Behavior;Behavioral;behavioral health;behavioral outcome;Birth;Brain;Brain region;Caring;Chicago;Child;Child Behavior;Child Care;Child Rearing;Childhood;Clinic;COVID-19 pandemic;Data;Dedications;design;Development;Developmental Delay Disorders;digital;digital applications;digital delivery;digital mental health;Discipline;Dose;Early Intervention;Educational Intervention;Educational process of instructing;effective therapy;Effectiveness;Emotional;Environmental Risk Factor;evidence base;Exhibits;experience;extreme prematurity;Family;follow-up;Frequencies;functional improvement;Gestational Age;Goals;Health Promotion;high risk;Hybrids;Impairment;improved;Individual;Infant;Internet;Interruption;Intervention;Learning;Literature;Logistics;Medical;Mental Health;Methods;Midwestern United States;National Institute of Child Health and Human Development;Neonatal Intensive Care;non-compliance;novel;Outcome;parenting intervention;Parents;peer;personalized approach;Persons;Population;Prefrontal Cortex;Premature Birth;Premature Infant;Prevention;preventive intervention;Problem behavior;programs;psychologic;psychosocial adjustment;public health priorities;Randomized;recruit;Regulation;Reporting;Research;Research Design;Research Priority;Resources;response;Risk;Self Efficacy;service delivery;Services;skills;social;social factors;Social Functioning;socioeconomic adversity;Sum;System;Technology;telephone coaching;Testing;Time;Toddler;Training Programs;Transportation;Waiting Lists

PROJECT_TITLE: Parent training for parents of toddlers born very premature: A factorial design to test web delivery and telephone coaching

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Disease;Pediatric;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Childhood Hepatitis B (HBV) infection remains a significant cause of morbidity and mortality in sub-Saharan Africa, and this is driven in part by vertical transmission during childbirth. Few studies have characterized the immunogenicity and potential impacts of adding a birth dose of HBV vaccine to the current 3-dose vaccination schedule in sub-Saharan African settings. This proposal uses epidemiological and mathematical modeling approaches to determine the impact of an HBV birth dose vaccine in order to inform policy in the Democratic Republic of the Congo.

PI_NAMEs: TULENKO, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Adopted;Africa South of the Sahara;African;Age;Age Months;Asia;Birth;Blood;burden of illness;career;Categories;Cause of Death;Cessation of life;Child;Childbirth;Childhood;Chronic Hepatitis;cohort;Communicable Diseases;Communities;Data;Data Analyses;Democratic Republic of the Congo;Development;Disease;Doctor of Philosophy;Dose;Dryness;Effectiveness;Epidemiologic Methods;epidemiological model;Epidemiology;Fellowship;Future;global health;Government;Grant;Health;Hepatitis B;Hepatitis B Antibodies;Hepatitis B Incidence;Hepatitis B Infection;Hepatitis B Prevalence;Hepatitis B Transmission;Hepatitis B Vaccines;HIV;HIV/AIDS;Horizontal Disease Transmission;Hour;Household;Immunity;immunogenicity;Immunology;improved;Incidence;Infant;Infant Health;infant infection;Infection;Infectious Disease Epidemiology;interest;Intervention;intervention program;Intervention Studies;Knowledge;Malaria;markov model;mathematical model;Measures;member;Mentors;Modeling;Morbidity - disease rate;mortality;Mothers;Newborn Infant;North Carolina;Physicians;Policies;prevent;protective efficacy;Province;Randomized;Research;Schedule;Scientist;secondary analysis;Series;skills;Spottings;Training;translational study;Tuberculosis;Universities;Vaccinated;vaccination schedule;Vaccines;vaccinology;Vertical Transmission;Viral hepatitis

PROJECT_TITLE: The impact of a Hepatitis B birth dose vaccine on HBV immunogenicity and incidence in children in the DRC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Neurosciences;Recovery Support Services;Rehabilitation;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE The long-term goal of this project is to test a virtual reality experience designed to reduce relapse and drinking, increase future orientation, decrease impulsive choice, and ultimately elevate the quality of life for persons recovering from alcohol use disorder. Through increasing future orientation with a potent personalized experience, the intervention targets increased brain activation related to beneficial decision-making and positive future outcomes. The results of this study will provide vital information on the effectiveness and brain mechanisms of this recovery support intervention intended to facilitate recovery outcomes.

PI_NAMEs: OBERLIN, BRANDON  (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Abstinence;addiction;Address;Aftercare;Age;aged;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol use disorder;Alcohols;Attention;Behavior;Behavioral;behavioral economics;behavioral outcome;Biometry;Brain;cingulate cortex;Clinical Trials;comparative efficacy;comparison group;Costs and Benefits;craving;Data;Decision Making;design;Development;digital;discounting;Disease;Dose;drinking;Drug usage;early alcohol use;Effectiveness;effectiveness testing;Emotional;endophenotype;Event;experience;feasibility testing;follow-up;Functional Magnetic Resonance Imaging;Future;Goals;hedonic;Impairment;improved;Impulsivity;Individual;Intervention;intervention effect;Investments;Laboratories;long term recovery;Longitudinal Studies;male;Measures;men;Motivation;multidisciplinary;neurobehavioral;neuroimaging;neurotransmission;novel;novel therapeutics;open label;optimism;Outcome;Participant;Patients;Persons;Pharmacotherapy;pilot test;Placebos;predictive marker;preference;prolonged abstinence;Quality of life;Randomized;randomized placebo controlled trial;Recovery;Recovery Support;Relapse;relapse patients;relapse prevention;response;Rest;Rewards;safety and feasibility;Sampling;Self Efficacy;Signal Transduction;Substance Use Disorder;success;sustained recovery;Testing;theories;Thinking;Time;Travel;treatment as usual;treatment duration;Treatment Efficacy;Treatment outcome;Validation;virtual;virtual reality;virtual reality environment;virtual reality intervention;virtual world;Visualization;Work

PROJECT_TITLE: Enhancing Prospection with Virtual Reality in Alcohol Use Disorder Recovery


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

PHR: PROJECT NARRATIVE Abnormal heart rhythms are a major cause of death and strokes in the US. Our research focuses on how the heart acquires its normal heart rhythm during development, so we can apply this knowledge to better understand why abnormal heart rhythms form in the adult heart. Using this approach, we have identified a key protein ERBB4 that is essential to maintain normal heart rhythm.

PI_NAMEs: PARK, DAVID S (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: acquired factor;Address;Adult;Aging;Arrhythmia;Atrial Fibrillation;Biological Models;Calcium;calmodulin-dependent protein kinase II;Candidate Disease Gene;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cause of Death;Cell Line;Data;Defect;defined contribution;Dependence;Development;Disease;Down-Regulation;effective therapy;Electrophysiology (science);Environment;erbB-2 Receptor;ERBB2 gene;ErbB4 gene;ETV1 gene;Evaluation;Functional disorder;Gene Dosage;gene regulatory network;Genes;genetic risk factor;Genetic Transcription;genome wide association study;Heart;Heart Abnormalities;Heart Atrium;Heart Diseases;Heart failure;heart rhythm;Histologic;hospital utilization;Human;Hypertension;Ion Channel;Knockout Mice;Knowledge;Left;Left atrial structure;Link;Maintenance;MAPK3 gene;Maps;Medical;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Muscle Cells;Mutant Strains Mice;Myocardium;Neuregulin 1;Neuregulin Receptor;Nodal;Optics;Pathogenesis;Pathway interactions;Patients;Physiological;Physiology;postnatal;Predisposition;Prevalence;Process;programs;Proteins;Public Health;Receptor Protein-Tyrosine Kinases;Research;Risk;Role;side effect;Signal Pathway;Signal Transduction;Sodium;Stroke;stroke incidence;Structure;success;Susceptibility Gene;System;Tamoxifen;targeted treatment;Therapeutic;Therapeutically Targetable;transcription factor;Transcriptional Activation;transcriptome;transcriptomics;Transgenic Mice;Tretinoin

PROJECT_TITLE: The Role of ERBB4 in Atrial Electrophysiology and Atrial Fibrillation

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Innate lymphoid cells are relatively poorly understood immune cell populations that play important roles in host defense, inflammation, allergic responses, tissue remodeling and metabolic homeostasis. Our research goals are to understand the fundamental biology of innate lymphoid cells, including their immunological and nonimmunological functions, molecular mechanisms of their regulation and migration, and their interactions with both pathogenic and commensal bacteria. Knowledge gained from these studies is expected to lead to the significant development of new therapeutic strategies for infectious, allergic and metabolic diseases.

PI_NAMEs: HUANG, YUEFENG  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Allergens;Allergic Disease;allergic response;Antigen-Antibody Complex;Antigens;Asthma;asthmatic;Autoimmune Diseases;B-Lymphocytes;Biological;Biological Assay;Biology;Bone Marrow;Cells;Cellular biology;Clinic;Collaborations;commensal bacteria;Common Lymphoid Progenitor;Communicable Diseases;cytokine;Cytokine Signaling;Development;Disease;Distal;drug candidate;Drug Screening;Drug Targeting;Drug usage;Extrinsic asthma;Flow Cytometry;Genetic;Goals;gut microbiota;helminth infection;Homeostasis;Host Defense;Human;Immune;immune function;Immune system;Immunologics;Immunology;immunoreaction;Infection;Inflammation;Inflammatory;injured;interdisciplinary approach;Intestines;Knowledge;Lung;Lymphoid Cell;Mediating;Metabolic;Metabolic Diseases;microbiota;migration;Molecular;Molecular Biology;mouse model;Mus;novel therapeutic intervention;Organ;Parasitic infection;pathogen;pathogenic bacteria;Play;Population;Positioning Attribute;receptor;Regulation;Reporter Genes;Research;Resources;response;Role;screening;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Skin;Surface;System;T-Lymphocyte;Tissue imaging;Tissues;trafficking

PROJECT_TITLE: Elucidation of the regulation and function of innate lymphoid cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Obesity;Prevention

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project narrative Approximately 26% of Americans have obesity and prediabetes. These conditions greatly increase the risk for the development of type 2 diabetes. Innovative lifestyle strategies to treat obesity and prediabetes are critically needed. If the aims of this application are achieved, this study will be the first to show that time restricted feeding can be implemented as an alternative to traditional dieting (i.e. daily calorie restriction) for long-term weight management. This study will also show that time restricted feeding can be used as an effective non- pharmacological therapy to improve insulin sensitivity and decrease metabolic risk in this population group.

PI_NAMEs: VARADY, KRISTA AMY (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Adherence;adult obesity;American;arm;Blood Pressure;Body Weight;Body Weight decreased;Caloric Restriction;Calories;Clinical;clinically significant;Closure by clamp;Consumption;Control Groups;Desire for food;Development;Diet;dietary adherence;dieting;disorder risk;Eating;Energy Intake;experience;Fasting;Food;Frustration;ghrelin;glucagon-like peptide 1;Glucose Clamp;gut microbiome;gut microbiota;Hormonal;Hormones;Hour;Human;Hunger;Hyperinsulinism;improved;Individual;Inflammation;inflammatory marker;innovation;Insulin Resistance;insulin sensitivity;Intake;Intervention;Investigation;LDL Cholesterol Lipoproteins;Life Style;Lipids;Maintenance;Measures;Metabolic;Metabolic Diseases;Methods;microbiome;Monitor;Non-Insulin-Dependent Diabetes Mellitus;Nonpharmacologic Therapy;Obesity;Oxidative Stress;Participant;Peptides;Pilot Projects;Plasma;Population Group;Prediabetes syndrome;Randomized;Regimen;Risk;Specific qualifier value;Structure;Testing;Time;Time-restricted feeding;Triglycerides;Weight;weight loss intervention;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: Time restricted feeding versus daily calorie restriction: Effect on body weight, metabolic risk, and the gut microbiome

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOLOGY

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative/ Relevance to Public Health Nucleo-Cytoplasmic Large DNA Viruses (NCLDVs) include some of the deadliest human and vertebrate pathogens known. This work will provide important insights into the past and present evolutionary processes that shape these viruses, while also laying the foundation for a new model system that can be leveraged to examine molecular dynamics of NCLDV infection in more detail.

PI_NAMEs: AYLWARD, FRANK O'NEILL (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Algae;Animals;Asfarviridae;Back;Biological Models;Carbon;Chlamydomonas reinhardtii;Complement;Complex;Cytoskeleton;Data;DNA Virus Infections;DNA Viruses;Elements;Eukaryota;Evolution;experimental analysis;Family;Family Study;Foundations;Gene Exchanges;Genes;Genetic;Genome;Green Algae;Human;immunoregulation;Inhibition of Apoptosis;insight;Interdisciplinary Study;Iridoviridae;Metabolism;mimicry;Modeling;Molecular;molecular dynamics;Nature;Nutrient;pathogen;Phycodnaviridae;Plants;Play;Poxviridae;Process;programs;Public Health;Recording of previous events;Research;Role;Shapes;Structure;System;tool;Translations;Vertebrates;Viral;Viral Genome;Virus;virus host interaction;Work

PROJECT_TITLE: Coevolutionary Dynamics and Gene Exchange Between Nucleo-Cytoplasmic Large DNA Viruses and Eukaryotes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative Turning on the right gene at the right time is essential for development and requires the dynamic recruitment of dozens of regulatory factors to specific genomic loci; defects in this process cause human disease. Emerging evidence supports a role for weak multivalent interactions in organizing regulatory factors into multi-component clusters that assemble and disassemble dynamically, yet these types of interactions have been difficult to study as they are only stabilized under specific conditions which enable cluster formation. Investigation into the mechanisms and functions of these weak multivalent interactions in the context of cluster formation will provide novel insights into a fundamental biological process with implications for developmental processes and aberrant gene activation in disease.

PI_NAMEs: SABARI, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Amino Acid Substitution;Amino Acids;Architecture;Back;Binding;Biochemical Process;Biological Assay;Biological Process;Biotinylation;C-terminal;Cell Nucleus;Cells;Complement;Complex;crosslink;Data;Defect;Development;Developmental Process;Disease;DNA Binding;DNA Polymerase II;Doctor of Philosophy;epigenomics;Exclusion;experimental study;Fluorescence;functional outcomes;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genomic locus;Grant;human disease;insight;Investigation;Knock-out;Knowledge;Learning;Libraries;Link;lipid biosynthesis;Mass Spectrum Analysis;Mediating;Mediator;Methods;Microscopy;Modeling;Molecular;Nature;negative elongation factor;novel;Nuclear Extract;Nuclear Proteins;Process;Protein Fragment;protein protein interaction;Protein Region;Proteins;Proteomics;Publishing;reconstitution;recruit;Reporter;RNA;Role;Specificity;Techniques;Testing;Time;tool;transcription factor;Transcription Process;Transcriptional Activation;unpublished works;Work

PROJECT_TITLE: Organization of transcriptional machinery by weak multivalent interactions

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Services;Kidney Disease;Patient Safety;Prevention;Urologic Diseases

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Fluid intake is a cornerstone of prevention for patients with kidney stones yet few patients adhere to fluid intake guidelines. Patient adherence can be supported by technology that monitors drinking behavior and delivers just-in-time reminders when patients have not had a drink recently. This project evaluates the efficacy of a sipIT, a digital tool involving a smartphone, smartwatch, and connected water bottle, for increasing fluid intake in patients with urolithiasis.

PI_NAMEs: CONROY, DAVID E. (contact);STREEPER, NECOLE

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;adaptive intervention;Adherence;adherence rate;Adult;Affect;Age;Algorithms;American;application programming interface;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Sciences;Biologic Characteristic;Biological;Cellular Phone;Clinical;clinical practice;Clinical Trials;cognitive performance;Companions;Consumption;Control Groups;cost;cost effective intervention;Cues;Custom;data exchange;Dehydration;Detection;Diet;dietary;digital technology;digital tool;Disease;Dissemination and Implementation;drinking;drinking behavior;Education;efficacy evaluation;efficacy testing;Emergency department visit;evidence base;financial incentive;fitbit;Focus Groups;Frequencies;Funding;Gestures;Goals;group intervention;Guidelines;Habits;Health;Health behavior change;healthy lifestyle;Heat Stress;Heterogeneity;hospital readmission;Hour;Hydration status;imaging study;improved;innovation;Intake;interest;Intervention;intervention effect;Kidney Calculi;Learning;Life Style;Liquid substance;Manuals;Mediating;Medical Care Costs;meetings;Methods;mobile application;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Negative Reinforcements;Notification;novel;Output;Pain;Patient Compliance;patient engagement;Patient Monitoring;Patients;Physical activity;prevent;Prevention;Prevention Guidelines;Randomized;Recording of previous events;Recurrence;Reminder Systems;Research;Salts;secondary outcome;Secondary Prevention;sensor;Series;Services;sex;Shapes;smart watch;smartphone application;support tools;Surrogate Endpoint;Surveys;System;Techniques;Technology;Testing;theories;Time;tool;treatment adherence;treatment as usual;treatment effect;treatment response;Urinary Calculi;Urinary tract infection;Urine;urolithiasis;Urologic Diseases;Water;wearable device

PROJECT_TITLE: Efficacy of sipIT Intervention for Increasing Urine Output in Patients with Urolithiasis

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Acquired hearing loss is prevalent throughout the world and accounts for, not only a significant cost to the lives of those living with it, but it also accounts for a significant monetary cost to individuals and societies. Hearing deficits can result from the loss of cochlear hair cells, which do not naturally regenerate in humans and other mammals leading to permanent impairment. Therefore, strategies to reprogram neighboring cells into hair cells will provide therapeutic targets for hearing restoration.

PI_NAMEs: MCGOVERN, MELISSA  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acquired Deafness;Affect;aging process;Alleles;Cell Maturation;Cell Reprogramming;Cells;Cochlea;cochlear development;cost;Data;Development;Dose;Epithelium;Family;Family member;Financial cost;Future;Gene Expression;Gene Family;Gene Modified;gene network;Genes;Genetic;genetic manipulation;Genetic Recombination;GFI1 gene;Goals;Grant;hair cell regeneration;Hair Cells;hearing impairment;hearing restoration;Human;Impairment;improved;Individual;Inner Hair Cells;Knowledge;Link;Loudness;Mammals;Medial;Mediating;Modeling;mouse model;Natural regeneration;Noise;normal aging;Organ of Corti;ototoxicity;permanent hearing loss;Pharmaceutical Preparations;Phenotype;Population;Predisposition;prevent;Production;programs;Publishing;regeneration model;Regulation;Role;Severities;single-cell RNA sequencing;Societies;stem cells;Supporting Cell;Supporting Cell of Organ of Corti;Testing;therapeutic target;Time;transcription factor;Vertebrates;Work

PROJECT_TITLE: Enhancing hair cell regeneration in the mature cochlea: Modulating Sox gene control of supporting cell identity

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative We propose to develop a fully automated precision oncology decision support system that unifies mutation characterization by levels of evidence, provides links to targeted therapies and via a user frontend can be integrated in clinical decision making in academic institutions and community medical centers.

PI_NAMEs: ANAGNOSTOU, VALSAMO  (contact);BOTSIS, TAXIARCHIS

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;actionable mutation;Address;advanced analytics;analytical tool;Architecture;Cancer Biology;Cancer Patient;Caring;Characteristics;Clinical;Clinical Data;clinical decision-making;Clinical Research;clinical trial enrollment;Clinical Trials;Communities;community partners;community setting;Complex;Computational algorithm;Consumption;Coupled;Data;Data Analyses;Data Element;data modeling;data standards;Databases;Decision Support Systems;design;Development;drug development;Elements;Environment;Face;Foundations;Genes;genomic data;Genomics;Genotype;Goals;Health;health care disparity;health care settings;health disparity;Health system;Healthcare Systems;Immunotherapy;improved;improved outcome;Individual;individual patient;Informatics;Infrastructure;Ingestion;Institution;Intuition;Investigational Drugs;Knowledge;knowledgebase;Label;Level of Evidence;Link;Literature;Mainstreaming;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;Maps;Medical;Medical center;Modality;Molecular;Molecular Target;multiple data sources;Mutation;Natural Language Processing;next generation sequence data;next generation sequencing;Oncologist;operation;Outcome;Patient-Focused Outcomes;Patients;Performance;personalized medicine;Population;pragmatic implementation;precision medicine;precision oncology;Precision therapeutics;Process;Records;Registries;Reporting;Research;Resources;Sampling;Solid;Source;standard of care;Standardization;targeted treatment;Terminology;Testing;Therapeutic;Therapy trial;Time;treatment trial;tumor;tumor diagnostic;United States Food and Drug Administration;Variant;Vertebral column;women's clinical trial

PROJECT_TITLE: Matching genotypes with personalized therapies: Development of a decision support infrastructure to augment the value of precision medicine


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: RELEVANCE (See instructions): Tuberculosis (TB) is a global health crisis that has frustrated efforts to treat and contain, and, unlike other bacterial infections that can be treated with a week-long course of a single antibiotic, TB therapy requires several drugs in combination for at least 6 months and often even this regimen does not work. In this project we will: (1) develop a better detection method for active TB in patient sputum samples through collaboration with a group in South Africa that works with TB-infected and HIV/TB-coinfected patients; (2) develop a better method for quickly and cost-effectively screening potential new TB drugs; and (3) conduct fundamental studies to determine how the outer layer of the pathogen that causes TB allows infection to happen. Our new method for clinical TB diagnosis should make it easier to determine whether TB drugs are working in patients; additionally, if they are not working well, new insight gleaned from this work may help us to better understand why.

PI_NAMEs: BERTOZZI, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: active method;Adamantane;Address;Affinity;analog;Antibiotics;Antigens;Bacteria;Bacterial Infections;Biological;Biology;Cell Culture Techniques;Cell Survival;Cells;Chemicals;Chronic lung disease;Clinical;Clinical Treatment;Collaborations;Combined Modality Therapy;Complex;cost;Detection;detection method;Development;Diagnostic Reagent;Drug Screening;Dyes;ebselen;Fluorescence;Frustration;Funding;Generations;Genetic;Glean;global health;Grant;Growth;high-throughput drug screening;HIV/TB;Hour;Image;In Vitro;Infection;inhibitor;insight;Instruction;Investigation;Knock-out;Label;Libraries;Lipids;magnetic beads;Mass Spectrum Analysis;Membrane;Metabolic;Methods;Microscope;Microscopy;model organism;Modeling;Molecular;mycobacterial;Mycobacterium Infections;Mycobacterium marinum;Mycobacterium tuberculosis;Natural Immunity;next generation;nile red;Participant;pathogen;Patients;Performance;performance tests;Pharmaceutical Preparations;Pharmacotherapy;point of care;point-of-care diagnostics;Population;Protocols documentation;Proxy;Reagent;Regimen;Resistance;Resource-limited setting;Role;Sampling;screening;South Africa;Sputum;Structure;supply chain;System;Time;Trehalose;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;Virulence;Visualization;Work;Zebrafish

PROJECT_TITLE: Chemical Mycobateriology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative We propose to use the systems biology approach combining in vitro, in vivo, and in silico experimental procedures, as well as human vessel specimens, to elucidate the mechanisms of blood flow regulation of endothelium. The resultant regulatory networks will provide critical information on vascular wall in normal and pathophysiological conditions. The study will also provide novel knowledge for atherosclerosis prevention, treatments, and management.

PI_NAMEs: CHIEN, SHU ;SHYY, JOHN YJ (contact);SUBRAMANIAM, SHANKAR

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Ablation;Affect;Aorta;Arteries;atheroprotective;Atherosclerosis;Bioinformatics;Blood flow;Blood Vessels;cardiovascular risk factor;Cell Communication;cell type;Cells;Cellular biology;Coculture Techniques;cohort;Data;data integration;Development;Disease;Endothelial Cells;Endothelium;Enhancers;Epigenetic Process;epigenome;epitranscriptome;experience;experimental study;Exposure to;Functional disorder;Funding;Gene Expression;Genes;Health;hemodynamics;Heterogeneity;Homeostasis;Human;Hyperlipidemia;Hypertension;in silico;In Situ;In Vitro;in vivo;Innate Immune Response;Knowledge;Link;longitudinal analysis;Macrophage;MADH2 gene;Maps;mechanotransduction;Mediating;Mediator;Modeling;Molecular;monocyte;mouse model;Multiomic Data;multiple omics;Mus;Nature;novel;Pattern;Phenotype;Prevention;Procedures;promoter;Property;Regulation;Regulatory Pathway;Resolution;response;Role;Sampling;Series;shear stress;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smooth Muscle Myocytes;spatiotemporal;Specimen;synergism;System;Systems Biology;Technology;Testing;Time;Tissue Sample;Transcript;transcription factor;transcriptome;Validation;Variant;Vascular Diseases;Vascular Endothelial Cell;Vascular Smooth Muscle

PROJECT_TITLE: Systems Biology Analyses for Hemodynamic Regulation of Vascular Homeostasis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Ovarian Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative: Understanding the age-associated changes which occur in both the epithelial and stromal cells during ovarian cancer initiation is critical to enable the development of early detection or prevention strategies in ovarian cancer. Our data suggest age-related changes occur in the stromal cells even before cancer starts and these stromal changes may promote the formation of cancer initiating cells (CIC) and invasive ovarian cancer. The goal of this proposal is to define the impact of age on interactions between stromal cells and cancer initiating cells (CIC) that drive ovarian cancer formation

PI_NAMEs: BUCKANOVICH, RONALD J;COFFMAN, LAN  (contact);FINKEL, TOREN

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 5'-AMP-activated protein kinase;Adopted;Age;age effect;age group;age related;age related changes;aged;Aging;AMP-activated protein kinase kinase;anti aging;anti-tumor immune response;BMP4;cancer cell;Cancer Cell Growth;cancer initiation;cancer invasiveness;Cancer Model;Cell Aging;Cell secretion;Cells;chemokine;Chronic;Clinical Trials;Colon;Data;Development;Diagnosis;Disease;DNA Damage;DNA Methylation;Early Diagnosis;epigenetic aging;Epigenetic Process;epigenomics;Epithelial Cells;Genetically Engineered Mouse;Goals;Growth;high risk;Homeostasis;Human;improved;In Vitro;in vivo;Inflammation;Inflammatory;Label;life span;Liver;Lung;Maintenance;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Maps;Mediating;Mesenchymal Stem Cells;Metformin;Modeling;mRNA Expression;multipotent stromal progenitor;Mus;novel;Organoids;Ovarian;Ovulation;Patients;Pattern;Phenotype;premalignant;prevent;Prevention strategy;Prognostic Factor;Protein Secretion;Proteins;Request for Applications;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;Serous;Site;spatial relationship;stem cells;Stromal Cells;Stromal Change;stromal progenitor;Supporting Cell;Time;Tissues;transcription factor;Transgenic Mice;tumor progression;tumorigenic;Wild Type Mouse;Woman;Work;wound healing;WT1 gene

PROJECT_TITLE: Defining the impact of stromal aging on ovarian cancer initiation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Pediatric;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative This program will support the continuation of a nine-week summer research program designed to facilitate the entry of promising young scientists into the field of alcohol and addiction research. The program provides trainees with a week-long series of lectures, followed by an eight week “hands-on” research internship, combined with a range of other training experiences throughout the internship period. The program is intended to enhance the knowledge, skills and experience of undergraduate participants and to prepare them for graduate school and careers as research scientists in health-related disciplines.

PI_NAMEs: GIZER, IAN ROBERT;MCCARTHY, DENIS M (contact);SHER, KENNETH JAMES

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: addiction;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Area;Award;Bachelor's Degree;career;Clinical;Communities;Complement;Data;design;Development;Discipline;Doctor of Medicine;Doctor of Philosophy;economic disparity;Economics;Educational Curriculum;Educational workshop;Employment;Enrollment;Epidemiology;ethnic minority;experience;Faculty;faculty mentor;Film;First Generation College Students;Genetic;Goals;graduate school;Growth;hands on research;Health;Human;Human Resources;human subject;improved;Individual;Individual Differences;Instruction;interest;Internships;journal article;Knowledge;Laboratories;lectures;matriculation;member;Mentors;Mentorship;Methods;mHealth;Minority;Missouri;Motion Pictures;Motivation;movie;neuroimaging;Neuropharmacology;neurophysiology;Occupations;Outcome;Participant;Postdoctoral Fellow;posters;Preparation;Process;Program Description;program dissemination;Program Effectiveness;Program Evaluation;programs;Protocols documentation;psychologic;Publications;racial minority;Recording of previous events;recruit;Research;Research Activity;Research Ethics;research faculty;Research Project Grants;Research Subjects;Research Training;Resources;responsible research conduct;Role;satisfaction;Schools;Science;Science, Technology, Engineering and Mathematics;Scientist;Secondary Schools;Series;skills;Societies;statistics;STEM field;Structure;Student recruitment;Students;success;summer research;Supervision;symposium;System;Technology;Technology Assessment;Training;Training Activity;Training Programs;trend;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: MU Alcohol Research Training Summer School (MU-ARTSS)


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Prediabetes and obesity are major public health issues that disproportionately affect racial/ethnic minorities and low-income individuals in the United States. The goal of this project is to assess the impact and sustainability of a digitally-based diabetes prevention program in changes in percent weight and HbA1c in English or Spanish speaking adults with prediabetes and obesity over the 12-month period.

PI_NAMEs: FUKUOKA, YOSHIMI  (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Impact and sustainability of a digitally-based diabetes prevention program

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Mitochondria and endoplasmic/sarcoplasmic reticula are “organelles” (structures) in cells that regulate cell metabolism and cell death. We have devised molecules that regulate proteins called mitofusins to alter the physical and functional relationships among these organelles and, thereby, influence cell death and metabolism. We propose in this project to (a) delineate mechanisms by which mitofusin modulators impact heart muscle cell metabolism and cell death and (b) test whether mitofusin modulators provide new therapeutic strategies for myocardial infarction (“heart attack”) and heart failure, the two most common and lethal heart diseases.

PI_NAMEs: KITSIS, RICHARD N (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Apoptosis;Apoptotic;Attenuated;Binding;Brain Ischemia;Cardiac Myocytes;Cell Death;Cells;Cellular Metabolic Process;Cessation of life;Collaborations;Data;endoplasm;Event;experimental study;Family;genetic approach;Goals;Guanosine Triphosphate Phosphohydrolases;Heart Diseases;Heart failure;heart function;heart metabolism;improved;in vivo;Individual;Infarction;inhibitor;Ischemia;Knockout Mice;Mediating;Membrane;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular Conformation;mouse model;Mus;myocardial infarct sizing;Myocardial Infarction;Myocardial Ischemia;Necrosis;new therapeutic target;novel therapeutic intervention;Organelles;Outer Mitochondrial Membrane;overexpression;Peptides;Phenocopy;Play;programs;Proteins;Reperfusion Therapy;Reporting;Respiratory Chain;Role;Sarcoplasmic Reticulum;Shapes;small molecule;Structure;Testing;Therapeutic

PROJECT_TITLE: Modulation of Mitofusin Activity to Treat Heart Disease


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Diabetes;Digestive Diseases;Genetics;Human Genome;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Obesity-related cancers, type 2 diabetes mellitus, and cardiovascular diseases, and their co-occurrence, are the biggest killers in the United States, dramatically impacting quality of life and longevity. The proposed study will evaluate how the health of your metabolism, regardless of body weight, impacts aging in your cells, risk of cancer and cancer survival. Findings could support changes in clinical management of obesity-related cancers to focus on diabetes and accelerated aging prevention, and help to better identify those at risk for disease prevention.

PI_NAMEs: KARRA, PRASOONA  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Abdomen;Address;Age;age acceleration;Aging;aging process;Atlases;bariatric surgery;Biological Aging;Biological Markers;Biometry;Blood;Blood Pressure;Body mass index;Body Weight;Body Weight decreased;Cancer Control;cancer diagnosis;cancer genomics;Cancer Patient;Cancer Prevention Intervention;Cancer Prognosis;cancer risk;cancer survival;Cancer Survivor;cancer type;Cardiometabolic Disease;Cardiovascular Diseases;career;Categories;cell injury;Cells;Cessation of life;Characteristics;Chronic;Classification;Clinical;Clinical Management;cohort;Colorectal;Data;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;disorder prevention;disorder risk;DNA Methylation;Epidemiology;epidemiology study;Epigenetic Process;Esophagus;Etiology;fasting glucose;Fatty acid glycerol esters;Female;follow-up;Framingham Heart Study;Gallbladder;Goals;Health;Health and Retirement Study;High Density Lipoprotein Cholesterol;high risk;Homeostasis;Human;Huntsman Cancer Institute at the University of Utah;improved;improved outcome;Incidence;Individual;Intervention;Jackson Heart Study;Link;Liver;Longevity;male;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediation;medical schools;meningioma;Metabolic;Metabolic dysfunction;Metabolic syndrome;Metabolism;Modification;mortality;Multiple Myeloma;Non-Insulin-Dependent Diabetes Mellitus;normal aging;Obesity;Obesity associated cancer;obesity risk;Ovary;Overweight;Pancreas;Participant;Patients;Persons;Phase;Phenotype;Physical Function;Play;population based;Postdoctoral Fellow;pre-doctoral;Premature aging syndrome;Prevalence;prevent;Prevention;prospective;Public Health;Quality of life;Race;Renal Carcinoma;Research;Research Personnel;resilience;response;Risk;risk stratification;Role;sex;Stomach;subcutaneous;Testing;The Cancer Genome Atlas;Thinness;Thyroid Gland;Time;Training;Triglycerides;United States;Utah;Uterus;waist circumference;Women's Health

PROJECT_TITLE: Metabolic health phenotype, accelerated aging and obesity-related cancer risk and mortality


NIH_SPENDING_CATS: Aging;Cancer;Skin Cancer

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Aging causes detrimental changes in the dermal compartment in human skin. Skin cancer occurs most frequently in older persons. The goal of this proposal is to investigate the novel hypothesis that age-related changes in the dermal compartment drive skin cancer initiation.

PI_NAMEs: DLUGOSZ, ANDRZEJ A.;FISHER, GARY J (contact);QUAN, TAIHAO

PROJECT_TERMS: Acceleration;Accounting;Address;Age;age related;age related changes;aged;Aging;aging related;aging related disease;American;autocrine;cancer initiation;cancer prevention;cancer type;Carcinoma;Cell Culture Techniques;COL1A2 gene;Cutaneous;cytokine;Dermal;Dermis;Development;Diagnosis;driver mutation;Elderly;Epithelium;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Funding Opportunities;Gene Deletion;Gene Modified;Genetically Engineered Mouse;Goals;Growth Factor;hallmarks of aging;HGF gene;Human;Incidence;Individual;Inflammatory;Intervention;keratinocyte;Keratinocyte cancer;Malignant Neoplasms;Modeling;Molecular;mouse model;Mus;Mutation;Names;National Cancer Institute;National Institute on Aging;notch protein;novel;novel therapeutic intervention;Older Population;paracrine;Pathway interactions;Peptide Hydrolases;Persons;Phenotype;Physiological;Production;Proteins;Publishing;Repression;secretory protein;senescence;Skin;Skin Aging;Skin Cancer;Skin Carcinogenesis;Skin Neoplasms;Source;Testing;Tissues;tool;TP53 gene;tumor initiation;tumorigenesis

PROJECT_TITLE: The Aging Cutaneous Microenvironment and Cancer Initiation


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Maternal Health;Microbiome;Pediatric;Pediatric - AIDS;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

PHR: PROJECT NARRATIVE Bacterial vaginosis (BV), an alteration in the vaginal microbiome, nearly doubles the risk of preterm birth (PTB), delivery prior to 37 weeks, and affects one third of women of reproductive age. In the US, women with HIV experience a two-fold increased risk of PTB compared to women without HIV and have been excluded from studies investigating the association between vaginal dysbiosis and preterm birth, contributing to ongoing disparities in this population. The proposed research will explore the role of vaginal dysbiosis in PTB among women with HIV with the vision that vaginal dysbiosis will be associated with a pro-inflammatory milieu, with altered cytokine and short chain fatty acid profiles, thus increasing the risk for PTB.

PI_NAMEs: POWELL, ANNA MAYA (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Acetates;adverse pregnancy outcome;Affect;African American Women;African Women;Age;Anaerobic Bacteria;anti-microbial peptide;antileukoprotease;Bacteria;Bacterial Counts;Bacterial Vaginosis;beta diversity;beta-Defensins;Bioinformatics;Biological;Butyrates;career development;Career Mobility;cervicovaginal;chemokine;Clinical;Clinical Trials Design;cohort;Cohort Studies;Communities;cytokine;Data;Data Analyses;design;Discipline of obstetrics;Disparity;dysbiosis;Environment;Exclusion;experience;experimental study;Financial cost;Foundations;Genitalia;Goals;Gynecology;Health Care Costs;health care disparity;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Human;improved;indexing;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;Institution;Interdisciplinary Study;Interleukin-1 beta;Interleukin-6;Intervention;Lactic acid;Lactobacillus;Lactoferrin;Learning;Liquid substance;Measures;Mediating;medical schools;Mentors;metabolomics;Metagenomics;microbiome;microbiome research;Mucositis;Output;Pathway interactions;Patient Recruitments;perinatal HIV;Physicians;Population;Positioning Attribute;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;preventive intervention;professor;Program Development;Propionates;reproductive;Research;Research Design;Research Personnel;Resources;Risk;Role;rRNA Genes;Sampling;Scientist;skills;Structure;Succinates;Techniques;Term Birth;Time;Training;Translating;transmission process;Universities;Vagina;vaginal fluid;vaginal microbiome;vaginal microbiota;vaginal mucosa;Viral Load result;Virus Shedding;Vision;Volatile Fatty Acids;Woman;women's outcomes;Work

PROJECT_TITLE: Vaginal Microbiome and Metabolites in Preterm Birth

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Childhood Injury;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Liver Disease;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Suicide;Underage Drinking;Unintentional Childhood Injury

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

ORG_STATE: ON

PHR: PROJECT NARRATIVE The United States is currently experiencing a decline in life expectancy due to an increase in mortality from poisoning, suicide, motor vehicle-related injuries, chronic liver diseases and cirrhosis, pneumonia and diabetes mellitus– for all of which alcohol use is a causal risk factor. The proposed project will investigate the role of alcohol use in these developments, with a focus on socioeconomic status and race/ethnicity as modifying factors on the link between alcohol use and mortality. Through simulation of the effects of different alcohol control interventions, the proposed project will provide tangible approaches to reverse the current decrease in life expectancy in the United States, while focussing on preventing further increases in health inequalities.

PI_NAMEs: PROBST, CHARLOTTE  (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: 18 year old;Accidental Injury;Adult;Affect;Age;age group;Alaska Native;alcohol availability;Alcohol consumption;alcohol effect;alcohol screening and brief intervention;Alcohols;American Indians;attributable mortality;Behavioral Risk Factor Surveillance System;Birth;Brain hemorrhage;burden of illness;Cause of Death;Censuses;Cessation of life;Characteristics;chronic liver disease;cost effectiveness;Data;Death Rate;Demographic Factors;Demographic Survey;Development;Diabetes Mellitus;drinking;Epidemiology;Ethnic Origin;Ethnic Population;evidence base;experience;Future;General Population;health equity;health inequalities;hypertensive heart disease;improved;Individual;Inequality;Injury;insight;Intervention;intervention effect;Life;Life Expectancy;Link;Liver Cirrhosis;Liver diseases;low socioeconomic status;model design;Modeling;models and simulation;Modification;mortality;mortality risk;Motor Vehicles;Myocardial Ischemia;National Health Interview Survey;Not Hispanic or Latino;Outcome Measure;Pattern;Play;Pneumonia;Poisoning;Population;population survey;Poverty;Premature Mortality;prevent;Price;primary outcome;public policy on alcohol;Race;racial population;Regulation;Research;Risk;Risk Factors;Role;scale up;screening and brief intervention;Series;sex;simulation;Socioeconomic Status;socioeconomics;Specific qualifier value;Subgroup;Suicide;Surveys;System;Taxation;Time;trend;United States;Vital Statistics;Vulnerable Populations

PROJECT_TITLE: A microsimulation of alcohol control interventions to advance health equity and reverse the current decrease in life expectancy in the US

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC FOUNDATION

PHR: Project narrative Disease modifying treatments for multiple sclerosis (MS) have many known serious risks, and healthcare expenditures related to MS DMTs account for 40% of the $85 billion total annual cost of MS care in the United States. While there is biological evidence and clinical data supporting the discontinuation of DMT for certain patients, there are no biological markers or clinical support tools to aide with the complex decision to stop MS DMTs. We propose the development, validation, and implementation of a point of care decision support tool utilizing machine learning to address this significant unmet need in the field of MS care.

PI_NAMEs: MCGINLEY, MARISA  (contact)

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

PROJECT_TITLE: A Decision Support Tool for the Discontinuation of Disease Modifying Therapies in Multiple Sclerosis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative: Impairments in decision-making are one of the most prevalent features of an alcohol use disorder, but remain the most difficult to treat. To address this critical gap, cutting-edge experimental and computational techniques will be applied in rodent models. This work will determine how brain systems can be targeted to improve decision-making by increasing the ability to plan and decreasing impulsive behavior.

PI_NAMEs: CZACHOWSKI, CRISTINE L;LAPISH, CHRISTOPHER COURT (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Address;Affect;Alcohol abuse;alcohol consequences;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;Animal Model;Animals;awake;Behavior;Behavior Control;behavior measurement;Behavioral;behavioral impairment;behavioral phenotyping;Biological;Brain;Brain region;cell type;Chronic;chronic alcohol ingestion;Computational Technique;Computer Models;cortical catecholamine;Cues;Data;data modeling;Decision Making;design;designer receptors exclusively activated by designer drugs;Development;Diagnosis;disorder risk;drinking;Electrophysiology (science);Exhibits;experimental study;Family;Family history of;Functional disorder;functional restoration;Future;generative models;Genetic;genetic approach;genetic risk factor;Goals;Heavy Drinking;Heterogeneity;Human;human data;human model;human subject;Impairment;improved;Impulsive Behavior;Impulsivity;Individual;Measures;Meta-Analysis;Modeling;Myopia;neural;neural circuit;neural correlate;neural patterning;Neurons;Neurophysiology - biologic function;novel;novel strategies;Pathology;Pharmacotherapy;Play;pre-clinical;preclinical study;Predisposing Factor;Prefrontal Cortex;Prevalence;Procedures;Process;programs;psychologic;Quinine;Recording of previous events;remediation;Research;Rewards;Risk;Risk Factors;Rodent;Rodent Model;Role;Series;Sex Differences;System;Techniques;Testing;Work

PROJECT_TITLE: Targeting computation in prefrontal cortex to improve decision-making and reduce compulsive drinking in rodent models.

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE The Bridges to the Baccalaureate Research Training Program at EPCC-UTEP will allow The University of Texas at El Paso (UTEP) and El Paso Community College (EPCC) to continue their longstanding collaborative efforts to effectively train research-oriented minority (primarily Mexican-American) undergraduate students who bridge from the community college into the university and complete baccalaureate degrees in biomedical fields. The program aims to diversify the pool of well-trained biomedical researchers and scientists who possess the requisite skills necessary to significantly contribute to the biomedical research workforce through mentored research experiences, interactive training workshops, community-building activities, and professional development opportunities.

PI_NAMEs: ESCAMILLA, REBECCA ;MALDONADO, ROSA A (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Academic achievement;Address;aspirate;Associate Degree;Awareness;Bachelor's Degree;Biomedical Research;biomedical scientist;bridge program;bridge to the baccalaureate;career;cohort;college;Communities;community college;Degree Completion;Degree program;Education;Educational Models;Family;Goals;higher education;Hispanic;Institution;interest;Internships;Knowledge;learning community;meetings;Mission;Outcome;Positioning Attribute;recruit;Reporting;Research;Research Personnel;Research Training;Schools;Science;Scientist;skills;Structure;Students;success;Texas;Training;Training Programs;transfer student;undergraduate research;undergraduate student;Underrepresented Populations;Universities;university student;Work

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) afflicts 5.8 million in the USA, but there remains no disease-modifying therapy. Critical for symptom progression is the loss of synapses in the brain. We seek to define the molecular basis of this synapse loss, focusing on the role of metabotropic glutamate receptor 5 (mGluR5) activation. In AD mice rescued from synapse loss by a mGluR5 targeting compound, we will profile the expression of genes in hundreds of thousands of brain cells to understand the complex interactions underlying this improvement. Changes in the shape of mGluR5 protein caused by AD will be studied by cryo electron microscopy to define the initiating molecular steps in AD.

PI_NAMEs: STRITTMATTER, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta oligomer;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Autopsy;base;Binding;Biological Markers;Brain;brain cell;Brain region;Cell surface;cell type;Cells;Cellular Assay;Chemicals;Clinical;Co-Immunoprecipitations;Complement 1q;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Dementia;Dendritic Spines;differential expression;dimer;Disease;disease phenotype;Disease Progression;Electron Microscope;excitatory neuron;Fluorescence Resonance Energy Transfer;Functional disorder;Gene Expression;Genes;Genetic;histological studies;Human;Hydrogels;Image;improved;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;inhibitor;Knock-in;Knock-in Mouse;Ligands;loss of function;Maps;Mediator;Memory impairment;metabotropic glutamate receptor 5;Methods;Microglia;mild cognitive impairment;Modeling;Molecular;Molecular Conformation;mouse model;Mus;Mutagenesis;Mutation;nanomolar;Neuroglia;Neurons;Oral;particle;Pathology;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;Phase Transition;Physiological;positive allosteric modulator;Positron-Emission Tomography;preservation;Process;protein complex;Proteins;PrP;recruit;Regulation;RNA;Role;Safety;Sampling;Schedule;Shapes;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;Symptoms;Synapses;tau aggregation;tau Proteins;tau-1;Testing;Therapeutic;Tissues;Toxicology;transcriptomics;Transgenic Mice;Transgenic Model;Transgenic Organisms

PROJECT_TITLE: mGluR5 and Phase State Dependent Synaptic Loss in Alzheimer's Disease

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Inaccurate nutrient sensing can result in diseases including type II diabetes, obesity, and cancer. This project will use powerful genetic tools and systems biology in eukaryotic microbes to characterize genetic mechanisms of signal integration within nutrient sensing networks. These mechanisms may provide new therapeutic targets to treat human metabolic diseases.

PI_NAMEs: HUBERMAN, LORI B (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Carbon;Cells;Cessation of life;Complex;detection of nutrient;Diabetes Mellitus;Disease;Distant;Enzymes;Eukaryota;Eukaryotic Cell;functional genomics;Fungi Model;fungus;Future;gene conservation;Genes;Genetic;genomic tools;Human;innovation;inorganic phosphate;Knowledge;Lipids;Malignant Neoplasms;Measurable;Mediating;Metabolic Diseases;Metabolism;Microbe;model organism;Molds;multiple omics;Neurospora crassa;new therapeutic target;Nitrogen;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Nutrient availability;Obesity;Organism;Output;p38 Mitogen Activated Protein Kinase;Pathway interactions;Phenotype;Phosphotransferases;Play;rapid growth;Regulation;response;Role;Saccharomyces cerevisiae;Signal Pathway;Signal Transduction;Source;Stimulus;Stress;Systems Biology;Therapeutic;therapeutic target;tool;tumor growth;tumor progression;Work;Yeast Model System;Yeasts

PROJECT_TITLE: Genetic mechanisms of signal integration in the nutrient sensing network

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Organ Transplantation;Primary Health Care;Social Determinants of Health;Substance Misuse;Transplantation

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Early liver transplantation (eLT), defined as LT evaluation with <6 months of alcohol abstinence, is associated with acceptable outcomes for patients with severe alcohol-associated liver disease (ALD) in retrospective studies. However, prospective, multi-center data including biopsychosocial factors on eLT for all patients with ALD in racially, culturally, and socioeconomically diverse populations are lacking. The INTEGRATE collaborative is a highly diverse investigative team that seeks to: 1) define factors influencing referral and waitlisting for eLT in ALD (selection); 2) identify which biopsychosocial factors are causally related and predictive of outcomes most important to stakeholders (outcomes); and 3) determine how integrated care among the healthcare team influences stakeholder-relevant outcomes in eLT for ALD (management).

PI_NAMEs: VANWAGNER, LISA B (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Abstinence;access disparities;Address;alcohol abstinence;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Behavioral Research;Biological Factors;biopsychosocial;biopsychosocial factor;candidate selection;career;Caregivers;Caring;Cirrhosis;Clinical;cohort;Communication;County Hospitals;Data;data harmonization;design;ethnic diversity;Ethnic Origin;Evaluation;Family;Focus Groups;Funding;Geographic Locations;health care disparity;health disparity;Hepatitis;improved;innovation;integrated care;Interview;Knowledge;Liver diseases;liver transplantation;Longitudinal cohort;Measures;Medical;Medical Care Team;Medical center;Medicine;member;Mental Health;Methodology;Methods;Michigan;Modeling;multidisciplinary;National Institute on Alcohol Abuse and Alcoholism;novel;organ allocation;Organ Donor;Organ Procurements;Outcome;outcome prediction;Pathway interactions;Patient Care;patient population;Patient-Focused Outcomes;Patients;Perception;Population;Population Heterogeneity;Positioning Attribute;preference;Process;prospective;Protocols documentation;Provider;Psychological Factors;Qualitative Evaluations;Race;racial diversity;Recurrence;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Retrospective Studies;Risk;risk prediction model;sex;social health determinants;socioeconomics;Sodium Chloride;stakeholder perspectives;Standardization;substance use;Surveys;survival prediction;Techniques;Texas;Time;transplant centers;transplant model;Transplantation;Underinsured;United States National Institutes of Health;Universities;virtual;Waiting Lists;Work

PROJECT_TITLE: 1/4-The INTEGRATE  Study: Evaluating INTEGRATEd Care to Improve Biopsychosocial Outcomes of Early  Liver Transplantation for Alcohol-Associated Liver Disease