NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Our objective is to determine if angiotensin-receptor blockers (ARBs) can enhance T cell infiltration into breast tumors and if this enhancement, when combined with cancer immunotherapy, can effectively reduce breast cancer progression. To accomplish this, we will measure T cell infiltration and function directly in mouse breast cancer models and we will also evaluate human breast cancer tissue samples to explore the potential synergy between ARBs and cancer immunotherapy. This research is of critical importance, considering the alarming annual toll of over 40,000 American lives claimed by breast cancer.

PI_NAMEs: JONES, DENNIS  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;advanced breast cancer;American;Angiotensin II Receptor;Angiotensin Receptor;animal data;Anti-Hypertensive Agents;Bioinformatics;Biomechanics;black women;Blood;Blood Vessels;Breast Cancer Cell;Breast Cancer Epidemiology;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;Breast Oncology;cancer cell;Cancer Etiology;cancer immunotherapy;cancer infiltrating T cells;Cell Adhesion Molecules;cell motility;Cell Physiology;Cells;Characteristics;checkpoint inhibition;Clinical;Collagen;combinatorial;Combined Modality Therapy;Computational Biology;Data;density;Deposition;Diagnosis;Diameter;Disease;effector T cell;Enrollment;Exclusion;Exhibits;Experimental Designs;Extracellular Matrix;FDA approved;Flow Cytometry;Functional disorder;functional improvement;Gene Expression;Gene Expression Profile;Gene Expression Profiling;High Endothelial Venule;Human;human disease;Image;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunology;Immunotherapy;Impairment;improved;in vivo;in vivo imaging;Infiltration;innovation;Interdisciplinary Study;intravital imaging;Losartan;lymph nodes;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;mechanical properties;Metastatic breast cancer;Methodology;microscopic imaging;mouse model;multidisciplinary;multiphoton microscopy;Mus;Neoplasm Metastasis;novel;novel therapeutic intervention;Optical Coherence Tomography;Organ;orthotopic breast cancer;outcome prediction;Patients;PD-1 blockade;Pharmaceutical Preparations;Phenotype;polyacrylamide;Positioning Attribute;Primary Neoplasm;Production;Prognosis;Property;Proteins;Publishing;recruit;Research;resistance mechanism;Resources;response;RNA analysis;Sampling;single-cell RNA sequencing;Solid;Specimen;spectrograph;Stains;Stress;stress reduction;Structure;success;Survival Analysis;synergism;T cell infiltration;T cell regulation;T-Cell Depletion;T-Cell Transformation;T-Lymphocyte;Testing;Time;Tissue Sample;Tissues;trafficking;transcriptome sequencing;transcriptomics;tumor;Tumor Burden;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-Associated Vasculature;United States;Woman;Women's Health;Women's mortality

PROJECT_TITLE: Improving anti-tumor immunity in advanced breast cancer by targeting solid stress


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Fibromyalgia;Mental Health;Neurosciences;Pain Research

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed project will characterize the phenotypic nature of cognitive dysfunction in fibromyalgia (FM) using a combination of self-report and objective measures of cognition, complemented by neurophysiological (EEG) and functional magnetic resonance (fMRI) outcomes. Cognitive symptoms are one of the most debilitating aspects of FM, are poorly understood and thus poorly managed, and are present in a wide range of chronic pain conditions beyond FM. Therefore, this project addresses a critical practical challenge that has applications for the improved healthcare management of a broad range of patients suffering from chronic pain.

PI_NAMEs: KAIRYS, ANSON  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Address;Adult;Affect;Anxiety;associated symptom;Attention;Behavioral;Biological Markers;blood oxygen level dependent;Brain;Central Nervous System;central sensitization;Chronic;chronic pain;chronic painful condition;chronic widespread pain;Clinical;clinical biomarkers;Cognition;Cognitive;cognitive function;cognitive performance;cognitive task;cognitive testing;common symptom;Complement;Complex;Computers;cost;daily functioning;Data;design;Development;Diagnosis;Dimensions;Disabling;Distress;Economic Burden;effective intervention;Electroencephalography;Elements;Employment;Equipment and supply inventories;Evaluation;Event-Related Potentials;Fatigue;Fibromyalgia;fibromyalgia pain;Fogs;Fostering;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;health management;Impaired cognition;Impairment;improved;Individual;Intervention;Knowledge;Laboratories;Learning;Left;Literature;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Memory;memory retrieval;Mental Depression;Mentors;Methods;Michigan;National Center for Complementary and Integrative Health;Nature;Nervous System Physiology;neural;Neurobehavioral Manifestations;Neurobiology;Neurocognitive;neuroimaging;Neurologic;Neurons;neurophysiology;Neuropsychology;neuroregulation;Outcome;Pain;Pain Free;pain symptom;Participant;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;Persistent pain;Phenotype;pre-clinical;pressure;processing speed;Protocols documentation;Psyche structure;Psychological Factors;psychological symptom;Reaction Time;recruit;Reporting;Research;Research Design;Research Personnel;Resolution;response;Rest;Role;Sampling;Sampling Studies;sensory stimulus;Short-Term Memory;Standardization;statistics;Symptoms;Techniques;Training;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Clearing the Fog: Characterization of the Phenotypic and Neurophysiological Features of Cognitive Dysfunction in Fibromyalgia

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Psychosis;Serious Mental Illness;Suicide

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Our team proposes to collect data from a large sample of people who experience hallucinations using smartphone behavioral measurement tools. With the aid of innovative computational modelling strategies, these data will be used to develop “clinical signatures” that indicate which individuals are at heightened risk for severe outcomes such as hospitalization and suicide. If successful, these measures and models can be used to guide scalable clinical decision making, resource allocation, treatment, and impactful prevention efforts.

PI_NAMEs: BEN-ZEEV, DROR  (contact);COHEN, TREVOR

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Adopted;Age;Area;behavior measurement;Behavioral;Cellular Phone;Chronic Care;Clinic;Clinical;clinical decision-making;clinical outcome measures;clinically relevant;cohort;Communities;Complex;Computer Models;Computing Methodologies;Data;Data Collection;Data Coordinating Center;Data Set;density;Detection;Development;Diagnostic;diaries;Dictionary;digital data;Ecological momentary assessment;Electronic Health Record;Emergency medical service;Environment;epidemiologic data;Evaluation;experience;FAIR principles;feature extraction;Functional impairment;General Population;Genetic Transcription;Hallucinations;Hospitalization;improved;indexing;Individual;Individual Differences;innovation;Intensive Care;Interview;Language;lexical;Machine Learning;machine learning model;Measurement;Measures;Memory;Mental disorders;Mental Health Services;Metadata;Methodology;Methods;Modeling;multidisciplinary;Natural Language Processing;neural;novel;Outcome;Paint;Participant;patient engagement;Patient Self-Report;Pattern;Persons;phenomenological models;Prevention;Process;prospective;psychotic;Race;recruit;Reporting;Resource Allocation;Resources;response;Risk;Risk Factors;Sampling;Secure;sex;Speech;speech recognition;Structure;Subgroup;suicidal risk;Suicide;Suicide attempt;Symptoms;System;Techniques;Technology;Testing;Text;Time;tool;Training;Transcript;verbal

PROJECT_TITLE: Developing Data-Driven Clinical Signatures for People Who Experience Hallucinations

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-S (01)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The overall goal of this project is to investigate the ethical questions that arise during the return of individual research results to participants involved in housing exposure studies. It will result in Household Exposure Results Report-Back (HERRB) guidelines, informed by participants in prior research studies and by diverse stakeholders. These guidelines will build the ethical competency of housing exposure researchers as they work to responsibly return results to participants in ways that build trust and support action by individuals and communities.

PI_NAMEs: HERINGTON, JONATHAN ;KORFMACHER, KATRINA S (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Adopted;Affect;Asthma;Back;Behavior;Clinical Trials;collaborative approach;Communication;Communities;Community Actions;community partners;community partnership;Competence;design;Development;driving force;economic implication;Effectiveness;energy efficiency;Ensure;Environmental Health;environmental justice;Ethics;experience;Family member;Feedback;Genomics;Goals;Guidelines;Health;health equity;health equity promotion;health inequalities;Health Personnel;Health Professional;Home;Household;Housing;improved;Incidental Findings;Income;Individual;Institutional Review Boards;interest;Interview;iterative design;Lead;legal implication;Literature;Low income;Maps;member;Methods;Modeling;non-genomic;Participant;Patient Recruitments;Policies;pragmatic trial;preference;Privatization;prospective;Provider;Public Health;remediation;Reporting;Reproductive Health;Research;Research Design;Research Personnel;research study;Safety;Scientist;study characteristics;study population;support tools;Surveys;tool;Trust;Typology;usability;Work

PROJECT_TITLE: Collaborative Development of Ethical Report-Back Guidelines for HouseholdExposure Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Neuropathic pain is a debilitating chronic pain condition that affects 6-8% of adults, the majority of whom do not adequately respond to currently available treatment options. We aim to establish a multidisciplinary team of scientists with expertise in pain biology, medicinal and computational chemistry, structural biology, pharmacology, pharmacokinetics, and translational pain research, and create the appropriate infrastructure for the development of novel non-opioid, 5-HT3 receptor antagonists for the treatment of neuropathic pain.

PI_NAMEs: ELGENDY, BAHAA  (contact);HAROUTOUNIAN, SIMON ;HEGAZY, LAMEES

PROGRAM_OFFICER_NAME: BACHMAN, JULIA LYNN

PROJECT_TERMS: ABCB1 gene;abuse liability;addiction liability;Adult;Adverse effects;Affect;Analgesics;Animal Model;antagonist;antinociception;Binding;Biochemical;Biological Assay;Biology;Brain;Bypass;Cells;Cerebrospinal Fluid;Chronic;chronic painful condition;Clinical;comorbidity;computational chemistry;Computational Technique;Computers;Data;design;Development;Distress;drug candidate;Drug Design;drug development;Drug Interactions;Drug Kinetics;drug metabolism;efficacy evaluation;Functional impairment;Future;Goals;Grant;Hypersensitivity;improved;In Vitro;in vivo;infrastructure development;Intellectual Property;Lead;lead candidate;Ligands;Literature;Mechanics;Mediating;Modeling;molecular dynamics;multidisciplinary;nerve injury;new chemical entity;non-opioid analgesic;novel;Ondansetron;Opioid;overexpression;Pain;pain behavior;pain model;Pain Research;painful neuropathy;Patients;Penetration;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;pharmacophore;Pharmacotherapy;Population;Positioning Attribute;pre-clinical;preclinical efficacy;Property;Quality of life;Rattus;Receptor Inhibition;response;Risk;Rodent Model;Safety;Scientist;Serotonin Receptors 5-HT-3;spared nerve;Specificity;Spinal Cord;spontaneous pain;structural biology;Structure;Structure-Activity Relationship;Testing;Therapeutic;Therapeutic Effect;Toxic effect;virtual screening

PROJECT_TITLE: Development of CNS-Active 5-HT3R Antagonists for the Treatment of Neuropathic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (18)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Eczema / Atopic Dermatitis;Food Allergies;Genetics;Nutrition;Prevention

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative The Mary H. Weiser Food Allergy Center and the closely associated Allergy and Clinical Immunology Division in Internal Medicine are submitting this application for a CoFAR clinical research center. The application is in three parts: Part A describes the extensive clinical/clinical research capabilities of the Center. Part B outlines a consortium-wide study project that investigates a new and potentially safer way to diagnose food allergy. Part C describes a local study that seeks to evaluate the unique genetic basis for the closely related disorders of food allergy and atopic dermatitis.

PI_NAMEs: BAKER, JAMES R. (contact);GUDJONSSON, JOHANN ELI;SCHULER, CHARLES F

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adult;Affect;Allergic Reaction;American;Anaphylaxis;Atopic Dermatitis;Basic Science;Biochemical Markers;Blood;Blood Vessels;cell type;Chromatin Modeling;Clinical;Clinical Immunology;Clinical Research;clinical research site;Clinical Trials;cohort;Data;Data Set;Databases;Diagnosis;diagnostic strategy;Diagnostic tests;Disease;Endowment;Environmental Risk Factor;Epidermis;Epithelium;Extravasation;Faculty;Food;food allergen;food challenge;Food Hypersensitivity;Functional disorder;Funding;Genes;Genetic;Genetic Risk;genetic risk factor;genetic signature;Genetic Techniques;genome wide association study;genomic locus;Genomics;Health;Hypersensitivity;improved;Incidence;Individual;Internal Medicine;Laboratory Research;Legal patent;Liquid substance;Measures;Mediator;Medicine;Mendelian randomization;Meta-Analysis;Michigan;Monitor;Multi-Institutional Clinical Trial;novel;novel diagnostics;operation;Oral;Participant;Pathogenesis;Pathogenicity;Patients;Pediatrics;Permeability;permissiveness;Physiologic Monitoring;Physiological;Predisposition;preservation;programs;Proteins;Quantitative Trait Loci;Reaction;Research;risk variant;Sampling;Serum;Severities;Signal Transduction;Site;Skin;skin barrier;Testing;therapeutic development;Time;Translational Research;Universities;Variant;Water

PROJECT_TITLE: University of Michigan MHWFAC CoFar CMC Center Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (J2)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: Smoking cessation among Veterans with chronic medical illnesses substantially decreases morbidity and mortality; however, many patients (>50%) with chronic pain continue to smoke and experience more barriers to smoking cessation. In a recently completed comparative effectiveness trial (IIR15-092), we compared a standard smoking cessation protocol (including pharmacotherapy) to a cognitive behavioral intervention (CBI) integrating an evidence-based smoking cessation intervention with a pain self-management intervention among Veterans with chronic pain. Though this intervention was significant (and promising), high rates of depressive symptoms were observed that may have interfered with optimal effectiveness. This proposal combines the established effectiveness of a CBI with the use of an Interactive Voice Response (IVR) system to enhance the effectiveness of the intervention in those without depression by allowing patients to interact with a computer-operated phone system and receive feedback to reinforce CBI skills, motivation, and self-monitoring.

PI_NAMEs: BASTIAN, LORI A (contact);DRISCOLL, MARY ;JOHNSON, RUDOLPH C

PROJECT_TERMS: Abstinence;Address;Area;arm;Behavioral;biopsychosocial;Chronic;chronic back pain;chronic pain;chronic pain patient;Cigarette;cigarette smoking;Clinic;Clinical;Clinical Trials;Cognitive;Cognitive Therapy;comparative effectiveness trial;Computers;Coping Skills;Counseling;Depressed mood;depressive symptoms;design;Effectiveness;Effectiveness of Interventions;evidence base;experience;Feedback;follow-up;Future;group intervention;Health behavior change;Health Promotion;Home environment;Hybrids;implementation science;improved;innovation;insight;Intervention;Intervention Studies;Medical;Mental Depression;Mental Health;Methodology;military service;military veteran;Monitor;Morbidity - disease rate;mortality;Motivation;Opioid;Pain;Pain intensity;Pain interference;Pain management;pain model;pain outcome;pain self-management;Patients;Pharmacotherapy;Population;prescription opioid;Prevalence;preventable death;Primary Care;primary endpoint;Process;programs;prolonged abstinence;Protocols documentation;Psychological reinforcement;Qualitative Research;Randomized;randomized trial;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;response;Risk Factors;Safety;Sampling;skill acquisition;skills;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;System;Technology;teleconsultation;Telemedicine;Telephone;Time;Tobacco;treatment arm;treatment as usual;Veterans;Voice;Work

PROJECT_TITLE: Enhancing an Intervention for Smokers with Chronic Pain using IVR: A Randomized Clinical Trial of Smoking Cessation Counseling for Veterans

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_DEPT: BIOLOGY

PHR: Project Narrative Genome architecture deteriorates during aging contributing to age-related pathologies. In this proposal we outline research related to one gene, SIRT6, which has been implicated as a regulator of mammalian life and health-spans; here we will investigate the molecular mechanisms by which SIRT6 maintains genome architecture. We are optimistic that our research will generate novel insights into the aging process and lead to therapeutic strategies designed to attenuate age-related diseases.

PI_NAMEs: SELUANOV, ANDREI  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: ADP ribosylation;Affect;Age;age related decline;Age related pathologies;age-related disease;Aging;aging process;Amino Acids;Antibodies;Applications Grants;Architecture;ATAC-seq;Attenuated;Automobile Driving;Back;Biochemical;Biological Process;Cell Aging;Cell Culture Techniques;Cell Physiology;Cells;Centenarian;ChIP-seq;Chromatin;Data;Deacetylase;Deacetylation;design;Deterioration;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Transposable Elements;Double Strand Break Repair;Enzymes;epigenetic clock;Epigenetic Process;epigenome;epigenomics;experimental study;extend lifespan;Funding;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Glycolysis;Goals;Health;healthspan;Hi-C;Histone H1;Histones;Immunofluorescence Immunologic;In Situ;In Vitro;in vivo;Inflammation;insight;Knock-in Mouse;Knockout Mice;Laboratories;Life;life span;Link;Longevity;Maintenance;MAPK8 gene;Mass Spectrum Analysis;Mediating;Modification;Molecular;mouse model;Mus;mutant;Mutate;Mutation;novel;Nucleosomes;Organ;overexpression;Oxidative Stress;Pathway interactions;Pattern;Peptides;Phenotype;Phosphorylation;Positioning Attribute;Prevention;Process;promoter;Proteins;recruit;Regulation;Repression;Research;Resistance;response;Role;senescence;senescent cell;Sirtuins;Site;SMARCA4 gene;SMARCC2 gene;Stress;Structure;Telomere Maintenance;Testing;Therapeutic;tumorigenesis;Variant;Work

PROJECT_TITLE: Regulation of epigenome stability by SIRT6 during Aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Food Allergies;Nutrition;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative-Clinical Research Center The increasing number of Americans afflicted by food allergies has become a major public health problem and there remains inadequate preventative or therapeutic strategies. Mount Sinai’s Consortium for Food Allergy Research Clinical Research Center will perform site-specific projects, propose a Network-wide clinical trial to the Leadership Center, and participate in Network-wide studies selected by the Leadership Center and NIAID program officers to address this unmet health need. We will conduct novel and impactful clinical trials and studies and incorporate mechanistic studies to advance prevention and management strategies and to improve knowledge on the origins and immune basis of food allergy.

PI_NAMEs: SICHERER, SCOTT H (contact)

PROJECT_TERMS: Address;Adult;Affect;Allergens;Allergic Disease;American;Anaphylaxis;Area;base;Biological;Biological Markers;Birth;Black race;career development;Caring;Characteristics;Child;Clinical;Clinical Research;Clinical Trials;Cohort Studies;community engagement;cost;Data;desensitization;design;Diagnosis;dietary;Dietitian;Disease;Disease remission;Economic Burden;Enrollment;Eosinophilic Esophagitis;Epidemiology;Equity;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;flexibility;Food;food challenge;Food Hypersensitivity;Food Protein-Induced Enterocolitis Syndrome;Future;Goals;Grant;Health;Hypersensitivity;IgE;Immune;improved;Intervention;Intervention Trial;Investigation;Knowledge;Laboratories;Leadership;Life;Manuals;Mediating;Mentors;Metabolic;National Institute of Allergy and Infectious Disease;next generation;novel;nutrition;Observational Study;Oral;Oral mucous membrane structure;Participant;Pathogenesis;Performance;Persons;Prevalence;prevent;Prevention;Procedures;programs;Protocols documentation;Public Health;Publications;Publishing;Quality of life;Reaction;Recovery;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Role;Safety;Salivary;Sampling;Shapes;Site;success;Systems Biology;Therapeutic;Therapeutic Trials;Translating;Voice;Work

PROJECT_TITLE: Mount Sinai's CoFAR Clinical Research Center


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The clinical response to chemotherapy and targeted therapy is often limited in duration, and some cancers are immediately refractory. This application will use multidimensional data to develop and preclinically evaluate a strategy for identifying effective drug combinations. The proposed strategy is aimed at overcoming therapeutic resistance and improving disease stratification.

PI_NAMEs: BENEVOLENSKAYA, ELIZAVETA V (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: acquired drug resistance;Address;Affect;Biological;Biological Assay;cancer care;cancer cell;Cancer cell line;cancer clinical trial;Cancer Patient;cancer therapy;Cell Death Induction;cell growth;Cell Line;Cell Survival;Cells;chemotherapy;Clinic;Clinical;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;computational pipelines;computerized tools;Data;Databases;design;Disease stratification;Drug Combinations;Drug Prescriptions;drug repurposing;drug response prediction;Drug Targeting;Drug Tolerance;Drug usage;Epidermal Growth Factor Receptor;Exhibits;Experimental Models;Exposure to;Fluorescence;Gene Expression;Gene Expression Profile;Genetic Transcription;Goals;Growth;Heterogeneity;improved;in silico;In Situ Hybridization;in vivo;Individual;individual patient;inhibitor;innovation;insight;Knowledge;lung cancer cell;Malignant Neoplasms;Maps;Methods;Modeling;multidimensional data;mutant;non-genetic;Non-Small-Cell Lung Carcinoma;novel strategies;novel therapeutics;Oncologist;Oncoproteins;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;Phenotype;Population;pre-clinical;predictive marker;prevent;Process;Refractory;Research;Resistance;response;RNA;Route;Safety;single molecule;single-cell RNA sequencing;small molecule;small molecule inhibitor;standard of care;success;targeted treatment;Testing;Therapeutic;therapeutic development;therapy resistant;transcriptome sequencing;tumor;tumor xenograft;Validation;Xenograft procedure

PROJECT_TITLE: Developing inhibitor combinations through identification of drug tolerant cell populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J2)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Asian Alcohol Flushing Syndrome impacts over 500 million people and is caused by a genetic variant in the ALDH2 gene that also causes a range of serious health conditions. This study will engage the East Asian American community to investigate how to implement genetic testing in clinical care and the effect of genetic testing for ALDH2 variants on modifiable health behaviors using a pragmatic comparative effectiveness trial. Results obtained in this study can aid implementation of genetic and genomic testing for marginalized groups in an equitable and ethical manner.

PI_NAMEs: YOUNG, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: Address;Affect;Alcohol consumption;Alcohols;aldehyde dehydrogenases;Alzheimer's Disease;arm;Asian;Asian Americans;Asian population;Attitude;Cancer Etiology;Cardiology;career;Chinese American;Clinical;clinical care;clinical practice;Communities;community advisory board;community engaged research;Community Healthcare;comparative effectiveness study;comparative effectiveness trial;Consult;design;dissemination science;drinking;drinking behavior;East Asian;Education;effectiveness/implementation hybrid;enzyme deficiency;Enzymes;Equity;Ethanol Metabolism;ethical, legal, and social implication;Ethics;Ethnic Population;evidence base;experience;Feedback;Flushing;Focus Groups;Foundations;Future;Genes;Genetic;Genetic Diseases;Genetic Services;genetic testing;genetic variant;Genomics;Genotype;Goals;Health;Health behavior;health equity;Healthcare;Healthcare Systems;hybrid type 2 trial;implementation facilitators;implementation framework;implementation science;improved;Individual;Intervention;Interview;Japanese American;Knowledge;Korean American;Learning Module;Life Style;lifestyle intervention;Link;Malignant neoplasm of esophagus;malignant stomach neoplasm;marginalized population;Measures;Mediating;Medical;Medical Genetics;member;Mentors;multidisciplinary;Myocardial Infarction;Oncology;Other Genetics;Outcome;Patients;Perception;Persons;Pilot Projects;Pragmatic clinical trial;pragmatic trial;preference;Prevalence;Preventive treatment;Primary Care;primary care provider;primary care setting;primary outcome;programs;Public Health;Qualitative Research;Randomized;Recommendation;Research;Research Personnel;Risk;Risk Reduction;screening;secondary outcome;skills;Specialist;Stroke;Structure;Surveys;Syndrome;Technology;Test Result;Testing;Training;treatment arm;underserved community;United States;Universities;Variant;Work

PROJECT_TITLE: A Community-Based Approach for ALDH2 Genetic Testing in East Asian Americans

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE DMGs are a universally lethal group of malignant brain tumors which affect both children and adults. A pathological hallmark of this disease is dysregulated transcriptional silencing, though the mechanisms are poorly understood. This proposal will define these molecular mechanisms and determine their relevance across DMG subtypes, thereby laying the framework for a novel therapeutic approach which can improve upon the standard of care radiation therapy in DMGs.

PI_NAMEs: PHILLIPS, RICHARD E (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Adopted;Adult;Affect;Biochemical;CDKN2A gene;Cell Line;Cells;Child;Childhood;Chromatin;Chromatin Structure;Cleavage Under Targets and Release Using Nuclease;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Data;Dependence;Diagnosis;diffuse midline glioma;Disease;DNA;Dominant-Negative Mutation;epigenetic silencing;FDA approved;Future;gene repression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genomics;Glioma;glioma cell line;Goals;Growth;Histone H3;Immunoprecipitation;improved;In Vitro;in vivo;knock-down;Knowledge;Link;Malignant neoplasm of brain;Mass Spectrum Analysis;Mediating;Mediator;Modeling;Molecular;multidisciplinary;mutant;Mutation;new therapeutic target;novel;novel therapeutic intervention;nuclease;Organoids;Pathogenicity;Pathologic;Patient Selection;Patients;Pharmaceutical Preparations;PRC1 Protein;pre-clinical;Protein Subunits;Proteomics;Radiation;Radiation therapy;recruit;Role;Site;standard of care;Testing;Therapeutic;therapeutic target;transcriptome sequencing;tumor growth;Tumor Suppressor Genes;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Deciphering mechanisms of transcriptional repression which drive midline glioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J1)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Digestive Diseases;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention

PHR: Narrative Epidemiologic data published by our group estimate that 1 in 13 children and 1 in 10 adults have food allergies, which in turn impose substantial psychosocial and economic burden on affected patients and families. The NUCoFAR Clinical Research Center proposes to advance the prevention, management, treatment of food allergy by leveraging the complementary expertise of its MPIs and their experienced, multi-institutional research team. The proposed site-specific project aims to understand the basic mechanisms of food allergy and oral tolerance, while the proposed network-wide project will develop a CoFAR-wide data commons, which will harmonize and aggregate a wide variety of clinical and epidemiologic data for analysis and future network- wide collaboration.

PI_NAMEs: BERIN, CECILIA ;GUPTA, RUCHI S (contact)

PROJECT_TERMS: access disparities;adaptive immune response;Address;Adherence;Adult;Affect;Age Months;Allergens;Area;Asthma;B-Lymphocytes;Biological;biomedical ontology;Cell Communication;Characteristics;Chicago;Child;Clinical;Clinical Data;Clinical Research;Clinical Trials;Collaborations;Collection;Communities;Complex;Complex Genetic Trait;Data;data access;Data Aggregation;Data Analyses;Data Commons;data harmonization;Data Scientist;data sharing;Development;Diagnosis;Diet;dietary;Disease;Disparate;Economic Burden;Eczema;epidemiologic data;Epidemiology;Etiology;Exhibits;experience;Faculty;FAIR principles;Family;feeding;Food;food allergen;Food Hypersensitivity;Future;Guidelines;Health;Health Services Accessibility;Health Services Research;high risk;Human;Hypersensitivity;Immune;Immune response;Immunity;Immunologist;Immunology;improved;Infant;Informatics;Ingestion;innovation;Institution;Intervention Studies;Intervention Trial;large datasets;Life;Mediating;medical schools;Memory B-Lymphocyte;microbial composition;Multi-Institutional Clinical Trial;multidisciplinary;new therapeutic target;novel;novel therapeutics;Observational Study;Ontology;ontology development;oral tolerance;Pathway interactions;patient population;Patients;Pediatric Hospitals;Physicians;Population;Pregnant Women;Prevention;Procedures;Productivity;Prognosis;psychosocial;Publications;Publishing;Quality of life;Reaction;Recommendation;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Resolution;Resources;response;Role;Science;Severities;Site;Source;Standardization;Structure;structured data;T-Lymphocyte;targeted treatment;Testing;Th2 Cells;trait;Universities;Work

PROJECT_TITLE: Northwestern University CoFAR (NU-CoFAR) Clinical Research Center


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The goal is to engineer viral vectors that are tightly controlled by Cre recombinase, showing essentially no expression in the absence of Cre. These FLEX2plasmids and AAV will be directly distributed by Addgene to the research community.

PI_NAMEs: PEREZ-REYES, EDWARD  (contact)

PROGRAM_OFFICER_NAME: KIM, EUNYOUNG

PROJECT_TERMS: Ablation;Acceleration;Award;Biosensor;Black Box;Brain;C57BL/6 Mouse;Cloning;Code;Collaborations;Communities;Coupled;Data;design;designer receptors exclusively activated by designer drugs;detection assay;diphtheria toxin fragment A;Effectiveness;Engineering;Enterobacteria phage P1 Cre recombinase;Epilepsy;Feedback;Funding;Future;Genes;Genetic;Genetic Recombination;Goals;Grant;Hippocampus;improved;in vitro testing;in vivo;interest;Internal Ribosome Entry Site;Interneurons;Introns;Jaw;Light;Maps;Mus;mutant;National Institute of Mental Health;neural circuit;Neurons;Neurosciences;novel;Open Reading Frames;Optics;optogenetics;Paper;particle;Plasmids;Production;promoter;protein biomarkers;Recurrence;Research;Research Personnel;Residual state;RNA Splicing;routine screening;Seizures;Serotyping;Site;sound;Source;Split Genes;Synaptophysin;Terminal Repeat Sequences;Testing;tool;transcriptome sequencing;transgene expression;Transgenes;Viral Vector

PROJECT_TITLE: Novel Cre-Dependent AAVs with Minimal Off-Target Expression to Study Neural Circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (01)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Liver Disease

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The SWI/SNF complex is a critical regulator of gene expression and is frequently mutated in a wide range of human diseases. This complex is combinatorially assembled from approximately 30 genes, yet we don’t understand how these assemblies are regulated or what the consequences are of having different compositions. The goal of this project is to define new mechanisms that regulate chromatin remodeler composition and function.

PI_NAMEs: RAAB, JESSE R. (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Affect;ATAC-seq;Binding Proteins;Biochemical;Cells;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;combinatorial;Complex;CRISPR screen;Data;Development;Disease;Enhancers;Environment;experimental study;functional outcomes;Gene Expression;Gene Expression Regulation;Genes;Genomic approach;Goals;graduate student;Hepatic Stellate Cell;Histones;Human;human disease;Immunoprecipitation;insight;Link;Liver;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Methylation;Modeling;Molecular;Mus;mutant;Mutate;novel strategies;novel therapeutics;Outcome;parent project;Phenotype;Play;Positioning Attribute;Post-Translational Protein Processing;Regulation;Regulator Genes;response;RNA;RNA Processing;RNA Splicing;Role;SMARCC1 gene;Students;SWI/SNF Family Complex;Training;transcriptome sequencing;transdifferentiation;tumor;Variant;Work

PROJECT_TITLE: Mechanisms of SWI/SNF complex assembly and function

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Viral encephalitis is a major cause of epilepsy that can induce short term seizures and long term, recurrent seizures in infected patients. Despite this public health burden, the etiology between seizures occurring during acute infection and chronically, post-viral clearance is unknown. Elucidating hippocampal and network mechanisms in the TMEV mouse model of viral-induced epilepsy across different timepoints may provide critical clues for manipulating seizure-active circuits and eventually lead to novel patient therapies.

PI_NAMEs: PETRUCCI, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3-Dimensional;Acute;acute infection;Address;Affect;Animals;Brain Hypoxia-Ischemia;C57BL/6 Mouse;career;Cell Death;cell type;Cells;Chimeric Proteins;Chronic;Chronic Phase;cytokine;cytokine release syndrome;Development;Disease;Encephalitis;Encephalomyelitis;Epilepsy;Epileptogenesis;Etiology;Exhibits;expectation;experience;experimental study;Familiarity;FOS gene;Foundations;frontal lobe;Future;General Population;Genetic Recombination;glial activation;Gliosis;Goals;Hippocampus;Human;Image;In Vitro;in vivo;Incidence;Individual;Infection;Inflammation;Inflammatory;innovation;Investigation;Knowledge;Lesion;Maps;Methods;Modeling;mouse model;Mus;neuron loss;Neurons;Neurosciences;novel;Organ;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Population;Process;promoter;Public Health;Pyramidal Cells;Recurrence;Refractory;Research;Research Personnel;Research Technics;Risk;Seizures;Solvents;Specificity;Status Epilepticus;Tamoxifen;Target Populations;Temporal Lobe Epilepsy;Testing;TMEV;Training;Viral;Viral Encephalitis;Virus;Virus Diseases

PROJECT_TITLE: Lesion extent and seizure propagation pathways across acute infection and chronic epilepsy in an infection induced mouse model

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative The San Diego Digestive Diseases Research Center (SDDRC) provides resources and infrastructure that bring together basic and clinical investigators as a means to enhance communication, collaboration and effectiveness in support of their research related to gastrointestinal and liver diseases. It also facilitates new research and the development of early-career investigators focused on digestive diseases.

PI_NAMEs: ECKMANN, LARS ;SCHNABL, BERND G. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Affect;Area;Automobile Driving;base;Basic Science;Bioinformatics;Biological;Biomedical Research;Biometry;California;career;Clinical;Clinical Investigator;Clinical Research;Collaborations;Communication;Consultations;cost effective;Dedications;design;Development;Digestive System Disorders;Direct Costs;Disease;early-career faculty;Ecosystem;Educational workshop;Effectiveness;Environment;Event;experience;Faculty;Feedback;flexibility;Fostering;Foundations;functional genomics;Funding;Gastrointestinal Diseases;gastrointestinal system;Gastrointestinal tract structure;Gnotobiotic;Goals;Grant;Health;high risk;Histopathology;Human;Immunology;improved;Individual;Inflammation;Inflammatory;Infrastructure;innovation;Institution;Investments;Joints;Laboratory Research;Link;Liver diseases;medical schools;member;Mentors;microbiome research;Mission;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;Paper;Patient Care;Phenotype;Play;Policies;Positioning Attribute;Pre-Clinical Model;Prevention;Productivity;programs;Publications;Radial;Research;research and development;Research Personnel;Research Support;Resources;Role;Secure;Services;success;symposium;System;Technology;Training and Education;Translational Research;United States National Institutes of Health;Universities;web site;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J4)]


NIH_SPENDING_CATS: Digestive Diseases

PI_NAMEs: SCHNABL, BERND G. (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Advocacy;Applications Grants;Area;Awareness;base;Basic Science;Biological;Biomedical Research;California;career development;Center Core Grants;Clinical Research;Communication;Communities;Community Outreach;Core Facility;Counseling;Country;Dedications;Development;Digestive System Disorders;Disease;Disputes;Educational workshop;Electronic Mail;Ensure;Event;experience;Faculty;Fees;Fostering;Funding;General Population;Goals;Grant;Guidelines;Health;Human Resources;Immunology;improved;Inflammatory;Institution;Leadership;Letters;Liver diseases;Maintenance;meetings;member;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;operation;Patients;Play;Preparation;Prevention;programs;Qualifying;Recommendation;Records;Research;Research Personnel;Research Project Grants;Resolution;Resource Allocation;Role;Seasons;Services;success;Supervision;symposium;Translational Research;United States National Institutes of Health;Universities;Update;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease;Liver Disease

PI_NAMEs: LOOMBA, ROHIT  (contact)

PROJECT_TERMS: Archives;bench to bedside;biobank;Biometry;California;chronic liver disease;Clinical;Clinical Pathology;clinical phenotype;Clinical Research;cohort;Collection;Complement;Consultations;cost effective;Coupled;Data Analyses;Data Management Resources;Diagnosis;Digestive System Disorders;Disease;Endoscopic Biopsy;experience;Faculty;Feces;Foundations;functional genomics;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;Grant;Histology;Hour;Human;human disease;human study;human tissue;Inflammation;Inflammatory Bowel Diseases;innovation;Knowledge;Leadership;Link;Liver;liver biopsy;Liver diseases;Machine Learning;Medical center;member;Metadata;microbiome research;Needle biopsy procedure;non-alcoholic fatty liver disease;Online Systems;Pathogenesis;Pathologic;Pathologist;Pathology;Patients;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Plasma;Pre-Clinical Model;Process;Productivity;Publications;Research;Research Design;Research Institute;Research Personnel;Resources;Sample Size;Sampling;Secure;Serum;Services;success;System;Testing;Tissues;training opportunity;Translational Research;translational scientist;translational study;Universities

PROJECT_TITLE: Human Translational Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease;Microbiome;Prevention

PI_NAMEs: KISSELEVA, TATIANA  (contact)

PROJECT_TERMS: animal care;animal facility;animal imaging;Animal Model;Animals;Antibodies;automated image analysis;Biochemistry;Board Certification;California;cell preparation;Cell Separation;Cells;Clinical;Complex;Consultations;cost;cost effective;data acquisition;Diet;Digestive System Disorders;Disease;Doctor of Philosophy;Educational workshop;empowerment;enteric infection;Evaluation;experience;experimental study;Financial Support;Fluorescence;Fluorochrome;Gastroenterology;Gastrointestinal tract structure;Generations;Genetically Engineered Mouse;Gnotobiotic;gut inflammation;Hepatocyte;Histologic;histological specimens;Histology;Human;Human Resources;humanized mouse;Immunofluorescence Immunologic;Immunology;Individual;Infection;Inflammation;Injury;innovation;Intestines;intravital imaging;Investments;Label;Liver;Liver diseases;Machine Learning;member;Microbe;microbial community;Microbiology;microbiota;microscopic imaging;Microscopy;Modeling;Molecular;mouse model;Mus;Organ;Paraffin;Pathologist;Phenotype;Physicians;Pre-Clinical Model;Prevention;programs;Protocols documentation;Publications;Reporting;Research;Research Personnel;Resources;response;Scanning;Scientist;Services;single-cell RNA sequencing;skills;Slide;Stains;stool sample;Surgeon;System;Techniques;Technology;tissue processing;Tissues;Training;transcriptomics;Transplantation;Universities;Veterinarians

PROJECT_TITLE: Preclinical Models Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Microbiome

PI_NAMEs: PRIDE, DAVID TEVIS (contact)

PROJECT_TERMS: Achievement;Bioinformatics;Biological Assay;California;Cells;ChIP-seq;Computational Biology;Consultations;cost;cost effective;Data;Data Analyses;Data Set;data visualization;Digestive System Disorders;empowerment;Ensure;experience;functional genomics;Funding;genomic data;Genomic medicine;Genomics;Grant;Hour;Human Resources;Infrastructure;innovative technologies;Institution;International;Large-Scale Sequencing;Leadership;Libraries;Medical Research;member;Metagenomics;metatranscriptomics;microbial community;microbiome;microbiome research;miRNA expression profiling;Molecular Genetics;new technology;next generation sequencing;Preparation;Procedures;Process;Productivity;Protocols documentation;Publications;Quality Control;Research;Research Personnel;Resource Sharing;Resources;Ribosomal RNA;Sampling;Services;Shotgun Sequencing;Side;single cell ATAC-seq;success;Support System;Techniques;Technology;Time;tool;Training;transcriptome sequencing;transcriptomics;Universities;Validation

PROJECT_TITLE: Microbiomics and Functional Genomics Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

PI_NAMEs: ECKMANN, LARS  (contact)

PROJECT_TERMS: Academia;Address;Advisory Committees;Area;Award;Biological;Budgets;California;career;career development;Categories;Communities;Consultations;Data;Development;Digestive System Disorders;Direct Costs;experience;Faculty;follow-up;Funding;Gastrointestinal tract structure;Generations;graduate medical education;Grant;Health;high risk;Home;Immunology;improved;innovation;Institution;interest;Investments;Leadership;Liver;member;Mentors;microbial;Mission;Mucous Membrane;novel strategies;Outcome;Pathogenesis;Peer Review;Personal Satisfaction;Preparation;pressure;prevent;Principal Investigator;Process;Productivity;programs;Publications;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Seasons;success;Time;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot and Feasibility Program


PROJECT_TITLE: Enrichment Program


FUNDING_MECHANISM: OTHERS

ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Cancer and cognitive problems including Alzheimer’s disease are common diseases of aging that often occur together and impose heavy burdens on patients and caregivers. Cancer patients with cognitive problems have worse health outcomes and need personalized cancer care that often cannot be met by current oncology clinic workflows. Growing telehealth use within the VA has helped relieve some of the burdens on patients and caregivers, and telehealth is expected to be an integral part of future VA cancer care. However, there is limited guidance on its use for complex patients. There is a critical need for oncology clinics to proactively design care processes that can meet the unique needs of older cancer patients with cognitive problems. The goal of this project is to deeply understand the telehealth oncology experiences of patients, caregivers, and clinicians in order to design and test a patient-centered intervention to improve telehealth cancer care delivery, so telehealth cancer care can be equitable for all Veterans regardless of age and memory and thinking abilities.

PI_NAMEs: HUANG, LI-WEN  (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;active method;Address;Adherence;Adverse effects;Age;age-related disease;aged;aging population;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Award;behavior change;cancer care;cancer diagnosis;Cancer Patient;cancer therapy;Cardiovascular system;care delivery;career;Caregiver Burden;Caregivers;Caring;Chronic Disease;Clinic;Clinical;Cognitive;Cognitive deficits;cognitive function;cognitive testing;comorbidity;Complex;Consent;Consolidated Framework for Implementation Research;Data;Dementia;design;Diabetes Mellitus;Diagnosis;Dimensions;Distress;efficacy testing;efficacy trial;Elderly;eligible participant;Emergency Situation;Environment;Equity;Etiology;Exhibits;experience;Feasibility Studies;Foundations;functional status;Future;Goals;health care delivery;Health Expenditures;Health Services Accessibility;Health Services Research;Healthcare Systems;Home environment;Hospitalization;Hospitals;human old age (65+);Image;Impaired cognition;Improve Access;improved;inclusion criteria;Intervention;Interview;Knowledge;Malignant Neoplasms;Memory;Mentors;Methodology;Methods;mild cognitive impairment;Modeling;mortality;Motivation;Nerve Degeneration;older adult;older patient;Older Population;Oncologist;Oncology;Outcome;Patient Care;patient oriented;Patients;person centered;personalized cancer care;Persons;Pharmaceutical Preparations;Physicians;pilot test;poor health outcome;Populations at Risk;Positioning Attribute;primary endpoint;Process;Provider;Psychologist;Quality of life;recruit;Regimen;Research;research and development;Risk;Scientific Advances and Accomplishments;secondary endpoint;Severities;Site;skills;Surveys;System;telehealth;teleoncology;Telephone;Testing;Thinking;Time;Training;Travel;treatment adherence;treatment effect;Treatment Efficacy;Treatment-related toxicity;usability;Veterans;Visit;Work

PROJECT_TITLE: Improving the Telehealth Delivery of Care for Older Veterans with Cancer and Cognitive Impairment

STUDY_SECTION_NAME: Mentored Physician and Clinical Psychologist Scientist Award in Alzheimer’s Disease and Related Dementias [MRA1]


ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative To build a more diverse scientific community in synthetic chemistry and a fundamental understanding of reaction mechanisms, this diversity supplement will support the training and development of a Hispanic, U.S. permanent resident Ph.D. candidate who will be conducting research in the areas mentioned in the parent grant, with an emphasis on the development of improved synthetic methods for the creation of pharmaceutical candidates by the elucidation of the mechanistic pathways of widely practiced reactions that form aryl C-N bonds.

PI_NAMEs: HARTWIG, JOHN F (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Area;aryl halide;Binding;career;Catalysis;Communities;Complex;Copper;Coupling;design;Development;Doctor of Philosophy;Educational workshop;Financial Support;Generations;Grant;Hispanic;improved;Instruction;Ligands;Manuscripts;Mentors;Methods;Oral;Oxidation-Reduction;parent grant;Pathway interactions;Peruvian;Pharmaceutical Chemistry;Pharmacologic Substance;Postdoctoral Fellow;pre-doctoral;Problem Solving;Reaction;Research;Research Methodology;Students;Surveys;symposium;Synthesis Chemistry;System;Testing;Training;Training Support;Transition Elements;United States National Institutes of Health;Vertebral column;Writing

PROJECT_TITLE: Discovery and Development of Organic Reactions Catalyzed by Transition Metals Valuable for Medicinal Chemistry

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Dr. Myers’ research projects address areas related to functional restoration in persons with chronic disease. His studies largely focus on applications of exercise therapy and other lifestyle factors to improve physical function, reduce disability, and lower health care costs in Veterans. These areas include studying the physiologic effects of rehabilitation in chronic diseases including chronic heart failure, coronary artery disease, spinal cord injury (SCI), and chronic kidney disease. These are important areas of research among Veterans because heart disease is the leading cause of death and disability in Veterans, and SCI and chronic kidney disease are the two most costly health conditions in the VA system. Dr. Myers’ studies are designed to reduce the overall burden of heart disease and other chronic conditions by improving physical function, reducing disability, and thus reducing health care costs associated with them.

PI_NAMEs: MYERS, JONATHAN N. (contact)

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Address;Affect;Age;Angiography;Angioplasty;Area;Back;Basic Science;Cardiac rehabilitation;Cardiology;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;career;Cause of Death;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;clinical application;clinical center;clinical database;Clinical Services;clinically relevant;cohort;Congestive Heart Failure;Coronary Arteriosclerosis;Cost Savings;Data;Data Set;Databases;design;Diagnosis;Diagnostic;disability;Disease;Epidemiology;Evaluation;Exercise;exercise capacity;exercise intervention;Exercise Test;Exercise Therapy;fitness;Fostering;functional restoration;Funding;General Population;Goals;Graph;Growth;Guidelines;Habilitation;Health;health application;Health Care Costs;health organization;Heart Diseases;Heart failure;heart rhythm;High Prevalence;Home;hospitalization rates;Human;Hypertrophic Cardiomyopathy;improved;indexing;Interdisciplinary Study;Internal Medicine;Intervention Trial;Investigation;Journals;Kidney Diseases;Left;Life Style;lifestyle factors;lifestyle intervention;male;Medicine;mild cognitive impairment;Molecular;multidisciplinary;Myosin ATPase;National Heart, Lung, and Blood Institute;New England;novel;Obesity;Online Systems;Operative Surgical Procedures;Outcome;Pain in lower limb;Paper;Patients;Pattern;Peer Review;Peripheral;Peripheral arterial disease;Persons;Physical activity;Physical Fitness;Physical Function;Physiological;Population;Prevalence;Prevention;Productivity;prognostic;programs;prospective;Publications;Publishing;pulmonary rehabilitation;Quality of life;Randomized;Recommendation;Recording of previous events;Registries;Rehabilitation therapy;relational database;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Role;Rural Health;Schedule;Science;Scientist;Seminal;Services;Site;Source;Specialized Center;Spinal cord injury;Stents;System;telehealth;Test Result;Time trend;Transducers;Transplantation;United States National Institutes of Health;Veterans;Walking

PROJECT_TITLE: Senior Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The proposed Kentucky Occupational Safety and Health Surveillance (KOSHS) program will 1) identify industries, occupations, and worker populations at high risk for work-related injuries and illnesses; 2) identify risk factors, trends, and emerging issues; 3) identify gaps in, and improve, occupational injury and illness surveillance systems; and 4) develop interventions for the prevention of occupational injuries. When injury prevention knowledge is attained by the worker, injuries on the job and the economic costs of injuries will decrease because there will be fewer workers’ compensation claims. Fewer occupational fatalities will occur and the severity of occupational injuries will be reduced.

PI_NAMEs: POPE, CAITLIN NORTHCUTT (contact)

PROGRAM_OFFICER_NAME: O'NEILL, EDUARDO

PROJECT_TITLE: Kentucky Occupational Safety and Health Surveillance Program


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cigarette smoking has severe negative health consequences for women who smoke and their children. During pregnancy many women are able to quit smoking but relapse shortly after delivery. Second-hand smoke exposure to newborns and infants increases their risk of both acute and chronic illness. Safe and effective smoking relapse prevention strategies that target the postpartum period are lacking. Sex hormones (progesterone and estradiol) have been shown to influence tobacco use behaviors in women during the postpartum period. This study proposes an innovative intervention to examine the effect of modifying progesterone and estradiol to prevent postpartum smoking relapse which will improve health outcomes for mothers and their children.

PI_NAMEs: ALLEN, SHARON S (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Abstinence;Acute;Addictive Behavior;Address;Age;Asthma;Attentional deficit;Behavior;behavior influence;Biological Markers;Blood;Breast Feeding;Cessation of life;Child;Childbirth;Chronic;Chronic Disease;cigarette craving;cigarette smoking;Clinic Visits;clinical translation;Collection;Cotinine;craving;Data;demographics;design;Development;Double-Blind Method;Drug abuse;Dryness;ear infection;efficacy evaluation;Enrollment;environmental tobacco smoke;environmental tobacco smoke exposure;Estradiol;ethnic difference;Ethnic Population;experience;female sex hormone;Gonadal Steroid Hormones;Good Clinical Practice;Health;health care availability;High Prevalence;Home;Hormonal;hormonal contraception;Hormones;Housing;improved;Income;Infant;Infant Health;Injectable;innovation;Intervention;Intramuscular;Literature;maternal cigarette smoking;maternal outcome;Measures;Mediating;Medroxyprogesterone 17-Acetate;Menstrual cycle;Mental Health;Methods;Mothers;Motivation;Newborn Infant;novel;Outcome;Ovulation;Participant;Patient Self-Report;Pattern;perceived stress;Performance;Pharmaceutical Preparations;Physiological;Pilot Projects;Placebos;Postpartum Period;Pregnancy;Pregnant Women;Premenopause;Prevalence;prevent;Prevention strategy;preventive intervention;primary outcome;Problem behavior;Procedures;Productivity;Progesterone;protective effect;Public Health;racial difference;racial population;Randomized;randomized placebo-controlled clinical trial;Relapse;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;Sampling Studies;Science;Self Administration;Shapes;Site;Smoke;Smoking;smoking abstinence;smoking cessation;Smoking History;smoking intervention;smoking relapse;smoking relapse prevention;Social Problems;Social support;Source;Spottings;Sudden infant death syndrome;Surveys;Tobacco use;urinary;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Oral and oropharyngeal squamous cell carcinomas occur with high incidence rates and prevalence in low- and middle-income countries (LMICs), with poor survival rates due to late diagnosis and treatment. We propose a mobile-based intra-oral imaging system, powered with deep learning image classification and patient triage to address the urgent need for a low-cost, portable, easy to use, and reliable method for oral cancer screening in LMICs. We expect that the mobile-based image classification and triage approach will eventually improve detection rates, treatment outcomes and quality of life of patients in LMICs.

PI_NAMEs: CHATURVEDI, PANKAJ ;LIANG, RONGGUANG ;RAJADHYAKSHA, MILIND  (contact)

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: 3D Print;Address;Algorithm Design;Algorithms;Arizona;Benign;cancer care;cancer prevention;Caring;Cellular Phone;Classification;classification algorithm;Clinic;Clinical;cloud based;Color;Computer software;Computer Vision Systems;Computers;contrast imaging;cost;deep learning;deep learning algorithm;design;Detection;Devices;Diagnosis;Early Diagnosis;Engineering;Europe;first-in-human;follow-up;handheld mobile device;Head and neck structure;Health Personnel;high risk;Home;Hospitals;Image;Image Analysis;image guided;Imaging Device;imaging system;improved;Incidence;Infrastructure;innovation;Institution;Internet;Knowledge;Learning;Lesion;Light;low and middle-income countries;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Memorial Sloan-Kettering Cancer Center;Methods;New York;novel;Oncologist;optical imaging;Oral;Oral cavity;oral lesion;Oropharyngeal Squamous Cell Carcinoma;Participant;patient population;Patient Triage;Patients;Performance;portability;Prevalence;prospective test;Quality of life;Reading;research clinical testing;Resource-limited setting;Resources;Sampling;screening;Screening for Oral Cancer;Sensitivity and Specificity;skills;Specialist;Specificity;Speed;Students;Survival Rate;System;teacher;Techniques;Testing;Texture;Treatment outcome;Triage;underserved area;Universities;Visual;volunteer

PROJECT_TITLE: Mobile phone-based deep learning algorithm for oral lesion screening in low-resource settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(55)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance: In this proposal, we plan to conduct a novel adaptive phase 1b/2 clinical trial (ADAPT-BLADDER) to study the clinical safety and efficacy, genomic biomarker signatures predictive of patient benefit, and mechanisms underlying tumor antigen-specific adaptive immune responses of innovative combination immunotherapy regimens to treat BCG-relapsing non-muscle invasive bladder cancer patients. This research will improve the overall public health of bladder cancer patients by providing data crucial to optimizing patient selection in future phase 3 studies with the ultimate goal of establishing new durable bladder-sparing options for BCG-relapsing patients. Furthermore, this proposal has important relevance to all cancers since the need to optimize combination immunotherapy approaches is not restricted to bladder cancer patients.

PI_NAMEs: HAHN, NOAH M (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute;adaptive immune response;Aftercare;Alternative Therapies;antigen-specific T cells;Antigens;arm;Attenuated;Bacillus Calmette-Guerin Therapy;BCG Live;biomarker signature;Bladder;Bladder Neoplasm;bladder transitional cell carcinoma;Blood specimen;Cancer Patient;CD8-Positive T-Lymphocytes;Cell surface;Cells;checkpoint therapy;Clinical;clinical efficacy;clinical practice;Clinical Trials;Clonal Expansion;Clone Cells;Combination immunotherapy;Combined Modality Therapy;Credentialing;Cystectomy;Data;design;Diagnosis;Disease;Eligibility Determination;exome;External Beam Radiation Therapy;Future;Gene Expression Profile;genomic biomarker;genomic signature;Genomics;Goals;high risk;Immune checkpoint inhibitor;Immunotherapy;Impairment;improved;Individual;Innate Immune Response;innovation;interest;Intravesical Administration;Investigation;Life;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Methods;MHC Class II Genes;Modernization;Mutate;Mutation;mycobacterial;nano-string;Natural Killer Cells;neoantigens;neutrophil;non-muscle invasive bladder cancer;novel;novel therapeutic intervention;novel therapeutics;Outcome;participant enrollment;Pathway interactions;Patient Selection;Patients;Peptide Library;Peptides;Peripheral Blood Mononuclear Cell;Phase;phase 3 study;phase change;Phase Ib/II Clinical Trial;phase III trial;point of care;point-of-care diagnostics;Population;precision medicine;Prediction of Response to Therapy;predictive signature;programmed cell death ligand 1;programmed cell death protein 1;prospective;Public Health;Quality of life;Radiation;recruit;Recurrent tumor;Regimen;Relapse;relapse patients;Research;Resistance;response;Safety;safety assessment;Sampling;Site;Solid Neoplasm;standard care;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;therapy resistant;Tissue Sample;Toxic effect;transcriptome sequencing;Transitional Cell Carcinoma;Transurethral Resection;treatment response;tumor;Tumor Antigens;tumor DNA;tumor immunology;Tumor-associated macrophages;tumor-immune system interactions;Urothelium

PROJECT_TITLE: Phase 1/2 Study of Modern Immunotherapy in BCG-Relapsing Urothelial Carcinoma of the Bladder - (ADAPT-BLADDER)

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Changes in cell fate are frequently triggered by ubiquitin-mediated degradation of regulatory proteins. Dysregulation of degradation or transcription is frequently associated with human diseases like cancer. Structural and biochemical insights into the mechanism of dynamic, coordinated transcriptional control, especially in a readily-screenable synthetic context, might allow new breakthroughs in molecular medicine.

PI_NAMEs: NEMHAUSER, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Auxins;Biochemical;Biology;cell behavior;Cells;chromatin modification;Complex;design;Development;Engineering;Eukaryota;Excision;Future;gene repression;genetic corepressor;Genetic Transcription;Genome;Heart;human disease;in vivo;insight;Kinetics;Link;Logic;Malignant Neoplasms;Maps;Mediating;Mediator;Modeling;Molecular;Molecular Medicine;Morphogenesis;novel;Organogenesis;Outcome;Pathway interactions;Plants;Property;protein complex;protein degradation;Proteins;Reaction Time;Repression;Research Project Grants;Resolution;response;RNA Polymerase II;small molecule;spatiotemporal;Structure;System;Testing;Therapeutic;Transcription Initiation;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;Transgenic Plants;Translating;Ubiquitin;Variant;Work;Yeasts

PROJECT_TITLE: Control of protein degradation and transcriptional dynamics in the auxin response


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hearing Loss;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: NARRATIVE The proposed research is relevant to public health in that it will lead to greater understanding of, and creation of more effective, behavioral interventions for those with central auditory dysfunction. Of particular relevance are older adults for which midlife hearing loss has been shown to be one of the greatest predictors of late life development of Alzheimer’s Disease and Related Dementias (ADRD). This work strongly aligns with the mis- sions of the NIA, and NICHD, which funded an R03 upon which the current proposal builds, the proposed re- search cuts across the bounds of numerous other NIH agencies, including the NCI, NIMH, NIAAA, NIHCD, NI- DA, NINDS, in that all of these agencies work with populations who could gain direct benefits from successful approaches to utilizing behavioral methods to enhance human well-being and performance.

PI_NAMEs: KOERNER, TESS ;SEITZ, AARON R (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 3-Dimensional;Address;Age;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Assessment tool;Auditory;auditory processing;Basic Science;Behavior Therapy;Behavioral;Binding;Central Auditory Diseases;Characteristics;Cognition;Cognitive;cognitive ability;Collection;Communication;comparison group;Computer software;Cues;Data Set;Dementia;demographics;Detection;Development;Environment;experience;Face;Frustration;functional independence;Funding;Goals;Hearing;Hearing Aids;hearing impairment;Human;Impaired cognition;Individual;Individual Differences;interest;late life;Literature;Long-Term Effects;Measures;Mediator;Methods;middle age;Mission;Modeling;Music;National Institute of Child Health and Human Development;National Institute of Mental Health;National Institute of Neurological Disorders and Stroke;National Institute on Alcohol Abuse and Alcoholism;older adult;Outcome;Outcome Measure;Participant;Perceptual learning;Performance;Peripheral;Personal Satisfaction;Personality;Persons;Population;Procedures;Process;prodromal Alzheimer's disease;Psychophysics;Public Health;Publishing;Qualifying;Quality of life;recruit;Rehabilitation therapy;remediation;Reporting;Reproducibility;Research;Research Personnel;Risk;Risk Reduction;Sample Size;Sampling;skills;social;sound;Source;Speech;Stimulus;Structure;Tablets;Testing;tool;Training;translational potential;Translational Research;Translations;United States National Institutes of Health;verbal;Withdrawal;Work;young adult

PROJECT_TITLE: Mediators and Moderators of Auditory Training


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Vanderbilt University proposes a 5-year renewal of its Training Program in Biomedical Informatics and Data Science, requesting 17 full-time training positions (9 predoctoral and 6 postdoctoral positions funded by NLM, and 1 predoctoral and 1 postdoctoral position in HIV informatics supported by NIAIDS) and 4 short-term training positions per year. This renewal will allow Vanderbilt to continue its successful training program to prepare the next generation of researchers at the forefront of biomedical informatics and data science.

PI_NAMEs: ANCKER, JESSICA S. (contact);MALIN, BRADLEY A.;UNERTL, KIM M

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Area;Bioinformatics;biomedical data science;biomedical informatics;career;Clinical;Clinical Informatics;Clinical Research;clinical translation;Collaborations;Competence;computer science;Course Content;Data Science;Degree program;Discipline;Doctor of Philosophy;Environment;experience;Faculty;Fellowship;Funding;graduate student;Grant;Health;Healthcare;HIV;Informatics;informatics training;Information Sciences;Institution;medical schools;meetings;National Institute of Allergy and Infectious Disease;Outcome;Pathway interactions;Persons;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Problem Solving;Productivity;programs;Public Health Informatics;Recording of previous events;Research;Research Methodology;Research Personnel;Research Training;Role;Social Sciences;Structure;Students;summer research;System;Tennessee;Time;Training;Training Programs;Underrepresented Populations;United States National Library of Medicine;Universities

PROJECT_TITLE: Vanderbilt Biomedical Informatics Training Program


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Cancer is a significant cause of morbidity and mortality worldwide. Immune-based therapies are showing great success in treating cancer; however, a large fraction of patients still fails to respond to these therapies. The proposed studies will advance our knowledge of the immune cells that drive response to therapy and how their modification relates to successful outcome.

PI_NAMEs: ANDERSON, ANA C (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Affect;Antigen-Presenting Cells;Antitumor Response;Biology;Cancer Patient;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Physiology;Cells;checkpoint receptors;Clinical;Communication;CTLA4 gene;cytokine;cytotoxicity;Data;Dendritic Cells;exhaust;Exhibits;gain of function;Generations;Genes;genome editing;Genomics;Goals;Human;Immune;immune checkpoint;immune checkpoint blockade;Immunotherapy;improved;Inflammatory;intercellular communication;Knockout Mice;Knowledge;Licensing;loss of function;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediator;Melanoma;Melanoma patient;Memory;Modification;Morbidity - disease rate;mortality;Mus;neoplastic cell;novel;Outcome;Patients;Phenotype;Play;Population;Positioning Attribute;Production;Productivity;programmed cell death protein 1;receptor expression;Regulation;Renal Carcinoma;Reporter;Reporting;response;RNA;Role;Sampling;stem;stem cells;success;T cell response;T-Lymphocyte;TCF Transcription Factor;Technology;Testing;tool;transcriptomics;treatment response;tumor;Tumor Antigens;tumor microenvironment;Tumor Tissue;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Regulation of stem-like CD8+ T cells and their role in immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: The ovarian TME is characterized by large numbers of immunosuppressive myeloid cells that reduce the effectiveness of current immunotherapies. Our data suggest that EGFL6, a protein secreted by OvCa cells, drives an accumulation of immunosuppressive myeloids cells cells in the tumors and inhibits the activity immune checkpoint inhibitor therapies. In this study, we will determine the mechanisms of EGFL6 immunoregulatory activity and evaluate the efficacy of EGFL6 neutralization as an adjuvant to immunotherapy.

PI_NAMEs: CASCIO, SANDRA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Adenocarcinoma;Adjuvant;angiogenesis;anti-tumor immune response;Antibodies;Antibody Therapy;Biological Response Modifiers;Bone Marrow;cancer cell;Cancer Model;Cancer Patient;cancer type;Carcinoma;CD8-Positive T-Lymphocytes;CD8B1 gene;cell motility;Cell Physiology;Cells;checkpoint therapy;comparison control;CXCL2 gene;cytotoxic;cytotoxic CD8 T cells;Data;Death Rate;Development;Effectiveness;Effector Cell;efficacy evaluation;EGF-Like Domain;EGFL6 gene;Engraftment;Event;extracellular;Gene Expression;Goals;granulocyte;Growth Factor;Human;Imaging Techniques;Immune checkpoint inhibitor;immune function;Immune response;Immunity;Immunocompetent;immunoregulation;Immunosuppression;Immunotherapy;improved;inhibitor;Integrins;Interleukin-10;JUN gene;knock-down;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;monocyte;mouse model;multiplexed imaging;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Natural Killer Cells;neutralizing antibody;neutrophil;novel;novel therapeutic intervention;ovarian neoplasm;overexpression;Phenotype;Phosphorylation;prevent;Production;programmed cell death ligand 1;programs;Proliferating;protein expression;Protein Secretion;Proteins;Recombinant Proteins;recruit;Refractory;Resistance;response;Role;S100A9 gene;Sampling;Signal Transduction;Spleen;Testing;Therapeutic;therapeutic target;Time;transcriptome sequencing;Transgenic Mice;treatment response;tumor;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic;Work

PROJECT_TITLE: The Role of Egfl6 in Tumor Immunity


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Newark

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative  Mucosal surfaces line the respiratory, gastrointestinal, and urogenital tracts and serve as the first barrier to foreign invasions due to specialized immune cells that reside at this boundary. With this work, we aim to engineer therapeutics that are optimized for the complex organ and mucosal movement to deliver critical instructions to the underlying immune cells and correct the improper immune functions that occur in a wide range of human diseases.

PI_NAMEs: FROMEN, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Antigen-Presenting Cells;Area;arm;Biological Models;Biology;Bypass;Cell Communication;Cells;Chemicals;combat;commensal bacteria;Complex;Cues;Dedications;design;Drug Delivery Systems;Engineering;Environment;Equilibrium;Evaluation;Future;Gastrointestinal tract structure;Goals;Home;Human body;human disease;Immune;immune function;Immune response;immunoengineering;immunoregulation;Infection;Instruction;Invaded;life span;Lung;mimicry;Modeling;Motion;Movement;Mucosal Immune System;Mucous Membrane;nanoparticle;novel;Organ;particle;pathogen;Pathogenicity;Physiological;programs;Regulation;Research;respiratory;Respiratory System;response;Route;Surface;System;Therapeutic;Therapeutic Uses;tool;urogenital tract;Work

PROJECT_TITLE: Multiscale considerations for immune engineering at mucosal interfaces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-R(55)R]


ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Elucidating the molecular underpinnings of arthritic pain is of vital importance for future treatment strategies. This proposal will study the mechanisms of nociceptor endocytosis involved in inflammatory pain. Conclusions from these studies will further validate the central role nociceptor endocytosis plays in inflammatory pain and reveal novel analgesic targets.

PI_NAMEs: BHATTACHARJEE, ARINDAM  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: 14-3-3 Family;Absence of pain sensation;Acute;Adaptor Protein Complex 2;Adaptor Protein Complex Subunits;Adaptor Signaling Protein;Adrenal Cortex Hormones;adverse drug reaction;Adverse effects;Analgesics;animal pain;antagonist;Arthralgia;arthritic pain;Arthritis;arthritis therapy;Axon;Binding;Biochemical;Biological Assay;Cartilage;Cell Fractionation;Chronic;Chronic inflammatory pain;chronic pain;Clathrin;Clinical Treatment;Complex;coping;Cyclic AMP-Dependent Protein Kinases;Data;Dense Core Vesicle;Development;Drug Targeting;druggable target;Endocytosis;Endocytosis Inhibition;Fiber;Future;Genes;Genetic;Glucocorticoids;Goals;Histology;Human;Hyperthermia;Impairment;in vivo;Inflammation;Inflammatory;inflammatory pain;inhibitor;Injections;Injury;Intra-Articular Injections;Joints;knock-down;Maintenance;Mediating;member;Methods;microCT;Modeling;Molecular;Mus;Mutagenesis;Neurons;Nociception;Nociceptors;novel;opioid overuse;opioid use;osteoarthritis pain;Outcome;Pain;pain behavior;Pain Measurement;pain model;pain reduction;pain relief;pain signal;Patients;Peptides;Peripheral;Pharmaceutical Preparations;pharmacologic;Play;preservation;prevent;protein expression;Protein Family;Protein Kinase C;Proteins;Rattus;recruit;Regulation;residence;response;Role;Saline;side effect;Signal Transduction;Site;Spinal Ganglia;Steroid therapy;Stress;Structure;Substance P;Technology;Testing;Therapeutic;trafficking;treatment strategy;Triamcinolone;TRPV1 gene;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Role of the Nociceptor Endocytosis in Inflammatory Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative In this project, we are developing instrumentation and methods to study virus capsids, bacteria, and extracellular vesicles at the single-particle level with higher spatial and temporal resolution. Analysis of single particles provides unprecedented insight into biological processes that is often missed when a population is studied as an ensemble. A more thorough understanding of the physical and chemical properties of these systems is of fundamental interest and will lead to improved therapies.

PI_NAMEs: JACOBSON, STEPHEN C (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Single-Particle Analysis of Virus Capsids, Bacteria, and Extracellular Vesicles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE This T32 postdoctoral training program will create a cadre of scholars with commanding knowledge and experience across the translational spectrum as well as a deep commitment to transdisciplinary team science. Scholars will receive a breadth of training as well as holistic and diverse mentoring. This will ensure that they have the knowledge and ability to communicate across boundaries, thereby increasing transdisciplinary cross- fertilization and accelerating healthcare advances.

PI_NAMEs: FAGERLIN, ANGELA  (contact);FAIRFAX, KEKE CELESTE

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TITLE: CTSA Postdoctoral T32 at University of Utah: Spheres of Translation Across the Research Spectrum (STARS) Training Program


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative Hearing loss affects the quality of life and productivity of millions of citizens. The sensory hair cell bundle transduction machinery is a major site of dysfunction for genetically induced, age-related, and noise induced hearing loss. The success of this proposal will provide an unprecedented understanding of how the sensory hair bundle functions and, in doing so, will be foundational in developing preventative and therapeutic interventions for hearing loss.

PI_NAMEs: MCGRATH, JAMIS  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Investigating the role of mechanotransduction machinery and the rootlet in modulating stereocilia motion.


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: PROJECT NARRATIVE Cancer-associated fibroblasts (CAFs) are a heterogeneous stromal cell population that influence disease course and treatment responses in aggressive cancers. Anaplastic thyroid carcinoma has a substantial stromal component, yet the composition of the stroma and its role in promoting malignancy remain unclear. In this proposal, I will elucidate the subtypes of CAFs in thyroid carcinoma and investigate the tumor-promoting effects of CAF-driven Wnt signaling, providing a novel therapeutic target for a disease with an urgent need for new treatment options.

PI_NAMEs: LOBERG, MATTHEW A (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Actins;Aggressive behavior;anaplastic thyroid cancer;anti-cancer research;autocrine;Automobile Driving;biobank;cancer cell;cancer heterogeneity;cancer subtypes;cancer type;career;Cell surface;Cells;Coculture Techniques;cohort;Colorectal Cancer;Common Carcinoma;Communication;Development;differential expression;digital;Disease;Disease Progression;Distal;Distant;effective therapy;efficacious treatment;exome sequencing;Experimental Designs;experimental study;fibroblast activation protein alpha;Fibroblasts;Future;Genes;genetic signature;Goals;Growth;Head and neck structure;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunotherapy;improved;in vivo;Indolent;Inflammatory;inhibitor;insight;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Modeling;Molecular Target;Monitor;Morphology;mouse model;Mus;Myofibroblast;nano-string;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Organoids;overexpression;pancreatic cancer model;Papillary thyroid carcinoma;paracrine;Patients;pharmacologic;Phenotype;Population;Proliferating;Publishing;receptor;Resolution;response;Role;Shapes;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Smooth Muscle;Space Perception;spatial relationship;Specimen;spheroids;stem;Stromal Cells;System;Techniques;Testing;Therapeutic;therapeutic target;Thyroid carcinoma;Thyroid Gland;thyroid neoplasm;Time;Training;transcriptome sequencing;Translational Research;Transplantation;treatment response;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;WNT Signaling Pathway;WNT2 gene;Work;Xenograft procedure

PROJECT_TITLE: Cancer-associated fibroblasts promote thyroid cancer malignancy through Wnt signaling


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative: Gene regulation is controlled in part through the binding of different proteins to DNA, proteins which control how DNA is organized and how it can be transcribed to RNA and from there to protein. Specifically, sequencing of protein-DNA interactions is logistically difficult and limited with current 2nd generation technologies: only short-range interactions are studied, extensive chemical or enzymatic treatments are needed, and heterogeneity is hard to probe. In this funding period, we are seeking to add to our toolbox to explore the epigenetic state of the human genome via measurement of modifications and insertions to the DNA sequence, with a focus on protein-DNA interactions.

PI_NAMEs: TIMP, WINSTON GEORGE (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;analysis pipeline;Antibodies;Area;Azides;Bar Codes;base;Binding;Binding Proteins;Binding Sites;Biology;Cells;Chemicals;Chromatin;Classification;cofactor;Collaborations;Color;combinatorial;Complex;Country;Cytosine;Data;Detection;Development;DNA;DNA Modification Process;DNA Sequence;DNA Sequence Alteration;DNA sequencing;DNA-Binding Proteins;DNA-Protein Interaction;Educational process of instructing;Enhancers;Enzymes;Epigenetic Process;epigenetic profiling;epigenetic variation;epigenome;epigenomics;Funding;Gene Expression;Gene Expression Regulation;Generations;Genetic Transcription;Genome;glycosylation;Grant;Heterogeneity;histone modification;human disease;Human Genome;human reference genome;Individual;insight;Label;Length;Malignant Neoplasms;Maps;Measurement;Measures;Methodology;Methods;Methylation;Methyltransferase;Modification;Molecular;Mutation;nanopore;novel;Nuclear;Organic Chemistry;Organism;Peptide Sequence Determination;Phase;Phenotype;Population;promoter;Proteins;Repetitive Sequence;Resolution;response;RNA;Sampling;sequencing platform;Signal Transduction;single molecule;Site;Somatic Cell;stem cells;Stimulus;Technology;Time;Tissues;tool;Training;Translating;Variant;Work

PROJECT_TITLE: Nanopore based profiling of epigenetic state


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_DEPT: MISCELLANEOUS

ORG_STATE: NY

PHR: Narrative In the past five years we have grown our biomedical informatics training program to be one of the best in the nation (see Progress Report) while serving a deeply economically and socially needy area of the US, and while recruiting an extraordinarily diverse cohort of students to a program that reflects the highest aims of the NLM training program’s intent and focus. We are even more excited by, and committed to, training our current and forthcoming students to be the researchers needed in biomedical informatics and data science: an essential (if not the essential) key to improving healthcare’s efficacy, efficiency, safety and responsiveness. Review of our program described in this document demonstrates how we have succeeded and continue to serve our trainees, the discipline’s next generation of world class researchers, and, indeed, to serve US healthcare with a carefully crafted and innovative NLM T-15 program.

PI_NAMEs: ELKIN, PETER L. (contact)

PROJECT_TERMS: 5 year old;Area;Award;Big Data;Bioinformatics;biomedical informatics;Clinical;clinical care;Clinical Informatics;Clinical Research;Complex;Depressed mood;Discipline;Doctor of Philosophy;doctoral student;Education;Educational Curriculum;Educational Technology;Educational workshop;Ensure;Ethics;Evaluation;Exclusion;Faculty;faculty mentor;Fellowship;flexibility;Frustration;Funding;Future;Genomics;Goals;Grant;Health;Health Technology;Healthcare;Human;improved;Informatics;innovation;insight;Institutional Review Boards;Judgment;Knowledge;Laboratories;Link;Location;Manuscripts;Medical;Medical Informatics;Mentors;Paper;Patient Care;patient safety;Peer Review;Policies;Positioning Attribute;Postdoctoral Fellow;programs;Public Health;Publishing;recruit;Research;Research Personnel;Research Training;skills;student mentoring;Students;Technology;Training;Training Programs;United States National Institutes of Health;United States National Library of Medicine;Universities;usability

PROJECT_TITLE: Buffalo Research Innovation in Genomic and Healthcare Technology Education (BRIGHT Education)


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative  Understanding systems-level neural mechanisms underlying anesthetic-induced unconsciousness can have tremendous translational benefit because it can significantly impact the development and delivery of anesthetic agents. Achieving this goal requires a whole-brain perspective as AIU is believed to be a brain network phenomenon. In this grant, we will fill this gap by elucidating how whole-brain networks are dynamically reorganized to support different patterns of information exchange from the awake state to unconscious states induced by distinct anesthetic agents.

PI_NAMEs: ZHANG, NANYIN  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Altered Level of Consciousness;Anesthesia procedures;Anesthetics;Animal Behavior;Animal Model;Animals;awake;behavior test;Biological Markers;Brain;Characteristics;Claustral structure;Conscious;Data;Development;Dexmedetomidine;Dose;Electrophysiology (science);experimental study;flexibility;Functional Magnetic Resonance Imaging;Goals;Grant;Graph;Immobilization;Individual;Isoflurane;Ketamine;Light;Link;Measures;Molecular;neural;neural circuit;neural network;neuromechanism;Parietal;Pattern;Property;Propofol;Rattus;Recovery;Reflex action;Research;Rest;segregation;Signal Transduction;Site;study characteristics;System;Testing;Thalamic structure;tool;Unconscious State;Volatilization;Wakefulness

PROJECT_TITLE: Elucidating dynamic reorganization of whole-brain networks during anesthetic-induced unconsciousness

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Developmental ethanol exposure leads to Fetal Alcohol Spectrum Disorders (FASD), which are characterized by physical, behavioral, and cognitive impairments. Microglia, the innate immune cells of the central nervous system, may play a role in alcohol's effects on the brain. This proposal will examine the role of cerebellar microglial dynamics and microglial interactions with cerebellar neurons in FASD pathology, and investigate whether microglia can be a potential target for FASD therapies.

PI_NAMEs: CEALIE, MAKENNA  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acute;Adult;Affect;Age;Agonist;Alcohol consumption;alcohol effect;alcohol exposure;Animals;ARHGEF5 gene;Attenuated;Behavior;behavioral impairment;Birth;Brain;Cell Communication;Cells;Central Nervous System;Cerebellum;Chronic;Control Animal;Dendrites;Development;Disease;Electron Microscopy;emerging adult;Ethanol;Evolution;experimental study;Fetal Alcohol Spectrum Disorder;Human;Image;Immune;immune activation;Immunohistochemistry;Impaired cognition;in vivo;in vivo two-photon imaging;Inflammation;Inflammatory;Inflammatory Response;Intervention;Knowledge;Learning;Life;Link;Long-Term Effects;Mediating;Mental disability;Microglia;Morphology;morphometry;Motility;motor impairment;mouse model;Mus;Neuroimmune;neuronal cell body;neuronal circuitry;Neurons;Output;Pathologic;Pathology;Phagocytosis;Phenotype;physical impairment;Pioglitazone;postnatal;PPAR gamma;Process;Purkinje Cells;Reporting;response;Rodent;Role;Shapes;Structure;Synapses;Testing;therapeutic target;Third Pregnancy Trimester;Time;time use;two-photon

PROJECT_TITLE: Effects of Developmental Ethanol Exposure on Cerebellar Microglia and Purkinje Cells


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Breast Cancer;Cancer;Comparative Effectiveness Research;Data Science;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE: The primary objective of this study is to develop statistical models and methods for evaluating existing or new cancer treatments for precision cancer medicine when synthesizing data from multiple resources, including evidence from randomized controlled trials (RCT) and real world data (RWD). We will rigorously evaluate the agreement of findings from RCTs and RWD, as well as develop algorithms to select optimal therapies determined by patients’ tumor subtype and other clinical features. The clinical findings will improve cancer practice guidelines leading to enhanced patient outcomes; and the novel statistical tools will be applicable to a broad range of cancer research and to building evidence-based clinical practice.

PI_NAMEs: NING, JING  (contact);SHEN, YU

PROGRAM_OFFICER_NAME: MARIOTTO, ANGELA B

PROJECT_TERMS: Agreement;Algorithmic Analysis;Algorithms;anti-cancer research;Biological;Breast Cancer Patient;Calibration;cancer care;Cause of Death;Cessation of life;Characteristics;Clinical;clinical care;clinical decision-making;clinical practice;Clinical Sciences;clinical subtypes;cohort;comparative effectiveness;Comparative Effectiveness Research;Computer software;computerized tools;Consumption;Coupled;Cox Models;Data;Data Aggregation;data integration;data registry;Data Sources;Databases;Development;Disease;Early treatment;Eligibility Determination;Equation;Equilibrium;evidence base;Evidence based treatment;flexibility;hazard;Heterogeneity;improved;Individual;individual patient;insight;Interdisciplinary Study;Isotonic Exercise;Knowledge;Learning;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;method development;Methodology;Methods;Modeling;Modification;multidisciplinary;multiple data sources;Nature;neoplasm registry;novel;Oncology;optimal treatments;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Population;population based;Population Study;Population-Based Registry;Practice Guidelines;Precision cancer therapy;precision medicine;precision oncology;prediction algorithm;Prediction of Response to Therapy;Probability;public health relevance;Randomized, Controlled Trials;Rare Diseases;Recommendation;Reproducibility;Research;Resources;Selection Bias;Selection for Treatments;semiparametric;Source;standard care;Statistical Methods;Statistical Models;stem;Subgroup;survival outcome;systematic review;Testing;Time;tool;treatment arm;treatment effect;Treatment Efficacy;treatment guidelines;Treatment Protocols;trial enrollment;tumor;Tumor Subtype;user friendly software;Variant;Weight

PROJECT_TITLE: Statistical Methods for Integration of Multiple Data Sources toward Precision Cancer Medicine

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]