NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: Goleta

ORG_NAME: PRAEVIUM RESEARCH, INC.

PHR: This effort is expected to impact public health by advancing a new high-speed, high-resolution, low-cost imaging technology capable of real-time three-dimensional structural and angiographic imaging of periodontal tissue over large volumes using swept source optical coherence tomography (SS-OCT). The proposed technology will enable imaging at previously inaccessible wavelengths and at speeds several times faster than previous SS- OCT dental imaging, ultimately enabling real-time whole mouth imaging for assessment of periodontal attachment, alveolar bone quality and level, gingival inflammation, sub gingival calculus plaque and tissue biotype. Such a system can also provide an objective means to determine and evaluate the prognosis of periodontal, regenerative, and restorative therapies, improve computer aided design and machining (CAD/CAM) capability for dental restorative procedures and planning, and become a reliable tool for long term monitoring and maintenance in clinical practice for oral health.

PI_NAMEs: JAYARAMAN, VIJAYSEKHAR  (contact)

PROJECT_TITLE: Next generation MEMS-VCSEL technology for ultra-low-cost dental and periodontal swept source optical coherence tomography imaging


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: KEAP1/NRF2 pathway are commonly mutated in NSCLC, but targeted therapies for patients with these mutations are lacking. I have identified novel antioxidant vulnerabilities for NSCLC cells harboring KEAP1 and NRF2 mutations. The proposed studies will define the mechanisms of these vulnerabilities and how these vulnerabilities can be exploited in order to develop potent therapeutic strategies for patients with KEAP1/NRF2 mutations.

PI_NAMEs: JIANG, CHANG  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Affect;Anabolism;antioxidant enzyme;Antioxidants;Biology;Cancer Center;career development;Cell Death Induction;Chemotherapy and/or radiation;Chronic;Compensation;Complex;Critical Pathways;Cytosol;Data;Defect;Dependence;design;Development Plans;dietary manipulation;Disulfides;dithiol;Drug Metabolic Detoxication;effective therapy;Electron Transport;Environment;Enzymes;Equilibrium;Genes;Glutathione;glutathione peroxidase;Glutathione Reductase;Goals;Homeostasis;in vivo;Incentives;Journals;Knowledge;Laboratory Research;Lipid Peroxides;lung cancer cell;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Mentors;Mitochondria;mutant;Mutate;Mutation;Non-Small-Cell Lung Carcinoma;novel;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidoreductase;Pathogenicity;Pathway interactions;Patients;Peer Review;Play;Positioning Attribute;Production;programs;Proteins;Publishing;Reactive Oxygen Species;Research;Resistance;Role;Selenium;selenoprotein;Signal Transduction;skills;Somatic Mutation;Sulfhydryl Compounds;System;targeted treatment;Therapeutic;therapeutic target;thioredoxin reductase;Training;transcription factor;Transcriptional Regulation;Translations;TXN gene;Up-Regulation;uptake

PROJECT_TITLE: Targeting antioxidant vulnerabilities in KEAP1/NRF2 mutant NSCLC

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Evidence of a greater burden of Alzheimer's causing abnormal protein, pathological tau, and more rapid cognitive decline in women versus men on the Alzheimer's trajectory makes it critical to examine female- specific Alzheimer's risk factors and pathways. Because inflammation in the brain (neuroinflammation) and testosterone show ties to tau and demonstrate sex differences, we propose to examine their relationships to tau burden and memory performance over 2-years in older women and how the modifiable risk factors of physical activity and obstructive sleep apnea (OSA) might influence these relationships. Finding answers to these questions will contribute to the identification of both therapeutic targets and lifestyle interventions that are tailored specifically for the sex that bears the greatest burden of AD.

PI_NAMEs: BANKS, SARAH  (contact);SUNDERMANN, ERIN ELIZABETH

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acceleration;Address;Adverse effects;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anti-Inflammatory Agents;associated symptom;Autoimmune Diseases;Biological;Biological Assay;Biological Factors;Brain;Central Nervous System;Cerebrospinal Fluid;Cognition;Cognitive;Cognitive deficits;cognitive function;cytokine;Data;Data Collection;Dementia;diet and exercise;Disease;Disease Outcome;Endocrine;Enrollment;experience;Female;follow up assessment;Funding;Genetic;Genetic Risk;Gonadal Steroid Hormones;Health;High Risk Woman;Hormones;Immune;Immune response;Impaired cognition;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Interleukin-6;Investigation;Joints;Knowledge;late life;Life Style;Life Style Modification;lifestyle factors;lifestyle intervention;Link;Measures;Mediating;Memory;men;Menopause;mild cognitive impairment;Modeling;modifiable risk;neuroimaging;neuroinflammation;Nonpharmacologic Therapy;Observational Study;Obstructive Sleep Apnea;older women;Outcome;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Performance;pharmacologic;Physical activity;Physical assessment;Pilot Projects;Play;Positron-Emission Tomography;Predisposition;Proteins;receptor;Receptors, Tumor Necrosis Factor, Type II;recruit;Reporting;Reproductive History;Research Priority;Risk Factors;Risk Reduction;Role;Sample Size;Sampling;sedentary lifestyle;Severities;sex;Sex Differences;sex disparity;Sleep;Stress;Symptoms;tau aggregation;tau function;tau Proteins;tau-1;Testosterone;therapeutic target;Time;TNF gene;TNFRSF1B gene;Tumor Markers;United States National Institutes of Health;Woman;women versus men;Work

PROJECT_TITLE: Biological and lifestyle factors contributing to Tau in women at risk for Alzheimer's disease.

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: EXIMIUS DIAGNOSTICS CORP

PHR: Project Narrative Hepatocellular carcinoma (HCC) releases extracellular vesicles (EVs) into the bloodstream at relatively early disease stages, making them ideal liquid biopsy markers for early HCC detection. This Direct-to-Phase-II SBIR proposal aims to further develop, optimize, and automate the HCC EV Surface Protein (SP) Test, ultimately establishing an in vitro diagnostic (IVD) test based on HCC EVs. Successful development of the HCC EV SP Test will enable a sensitive, EV-based IVD test for detecting early-stage HCC.

PI_NAMEs: CHUANG, HAN-YU ;LIU, SEAN XIAO;TSENG, HSIAN-RONG  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Ablation;Adopted;Advanced Development;Affect;Alcoholic Liver Diseases;Algorithms;Antibodies;ANXA5 gene;arm;assay development;Automation;Bar Codes;Bioinformatics;Biological Markers;biomarker development;Biometry;Blood Circulation;Cancer Etiology;Case/Control Studies;CD81 gene;cell type;Cells;Cessation of life;Chemistry;Chronic Hepatitis B;circulating biomarkers;Circulation;Cirrhosis;Clinical;Clinical Practice Guideline;cohort;Detection;detection sensitivity;Development;Diagnosis;Diagnostic;Diagnostic tests;diagnostic value;Disease;DNA;early detection biomarkers;Early Diagnosis;Etiology;Excision;Exhibits;extracellular vesicles;Goals;GPC3 gene;Guidelines;Hepatitis B;Hepatitis C;hepatocellular carcinoma cell line;Hepatology;Hour;in-vitro diagnostics;Individual;innovation;Joints;lipid nanoparticle;liquid biopsy;Liver;Liver Cirrhosis;Liver diseases;liver transplantation;Mediating;Medical center;Membrane Proteins;Methods;Modality;molecular pathology;Motivation;nanoparticle;neoplastic cell;non-alcoholic fatty liver disease;novel marker;Oncology;Operative Surgical Procedures;Paper;Pathology;Patients;Performance;Phase;Phospholipids;Plasma;predictive modeling;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Process;product development;Prognosis;Protein Analysis;Quantitative Evaluations;Recommendation;Research;Risk;robotic system;Robotics;Sampling;Serum;Site;Small Business Innovation Research Grant;Specificity;Specimen;Surface;System;Systems Development;TACSTD1 gene;technology platform;Testing;Time;Training;tumor;tumor microenvironment;Tumor-Derived;Ultrasonography;ultrasound;Validation;Viral hepatitis;α-Fetoproteins

PROJECT_TITLE: Developing and Automating an Extracellular Vesicle-Based Test for Early Detection of Hepatocellular Carcinoma


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE This grant will support training of a new generation of graduate and undergraduate students in computational neuroscience. Computational neuroscience contributes to fundamental knowledge about brain function and behavior and to more precise characterization of brain disorders.

PI_NAMEs: MA, WEI JI  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: academic preparation;Behavior;Brain;career;Cognition;Collaborations;college;Communities;Compensation;computational neuroscience;Development;doctoral student;Educational Curriculum;Educational workshop;Exposure to;Faculty;Funding;Goals;Infrastructure;Journals;Laboratory Research;Mathematics;Measures;Mentors;neural;Neurosciences;New York;Perception;pre-doctoral;Productivity;programs;Psychology;Research;Role;Rotation;Running;Science;skills;Students;Traineeship;Training;Training Programs;undergraduate student;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Training program in computational approaches to brain and behavior


NIH_SPENDING_CATS: Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Summary Rationale: To understand the many disorders of the brain it is necessary to grapple with its complexity. Increasingly large and complicated data sets are being collected, but the tools for analyzing and modeling the data are not yet available. More researchers trained in computational neuroscience are desperately needed. This project supports interdisciplinary graduate training programs in computational neuroscience (TPCN) at both Carnegie Mellon University (CMU) and the University of Pittsburgh (Pitt), and a summer school in computational neuroscience for undergraduates, which are available to students coming from colleges and universities throughout the United States. Carnegie Mellon University (CMU) is a world leader and innovator in quantitative fields such as machine learning, computer science, and artificial intelligence, and recently, neuroscience has emerged as a field for strategic growth at the university. The University of Pittsburgh is renowned for the strength of its clinical and biomedical research programs. The TPCN is set within a highly collegial, cross-disciplinary environment of our Center for the Neural Basis of Cognition (CNBC), which is operated jointly by CMU and Pitt. The CNBC was established in 1994 to foster interdisciplinary research on the neural mechanisms of brain function, and now comprises 162 faculty having appointments in 32 departments. Goals: The goals of the TPCN are to: 1) Support computational training of PhD students across the neurosciences, 2) Broaden accessibility for students historically underrepresented in STEM by augmenting an existing MS-to-PhD training program that prepares them for advanced graduate training in computational neuroscience, 3) Expand computational training of undergraduate students through a formal academic minor in computational neuroscience, 4) Support an undergraduate summer program that combines a two-week “boot-camp” overview of computational neuroscience with an 8-week research experience, 5) Create online materials that not only serve our own students but are publicly available on the web, and 6) Enhance our recruitment through relationships we have developed with minority-serving institutions.

PI_NAMEs: CHASE, STEVEN M (contact);TORRES-OVIEDO, GELSY

PROJECT_TERMS: academic minor;Appointment;Artificial Intelligence;Biomedical Research;Brain;Brain Diseases;Clinical Research;Cognition;college;computational neuroscience;computer science;data modeling;Data Set;Doctor of Philosophy;doctoral student;Environment;experience;Faculty;Fostering;Goals;Growth;Interdisciplinary Study;Internet;Machine Learning;Minority-Serving Institution;neural;neuromechanism;Neurosciences;programs;recruit;Research;Research Personnel;Schools;Students;summer program;tool;Training;Training Programs;undergraduate student;United States;Universities

PROJECT_TITLE: Interdisciplinary Training in Computational Neuroscience


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The field of neuroscience is experiencing a renaissance in terms of the scale and complexity of the datasets that are now routinely collected. It is crucial that the next generation of neuroscientists are able to synthesize, organize, and model these datasets, with the goal of building new theories of the brain. The central goal of our training program will be to train the next generation of neuroscientists with the strong quantitative skills needed to advance the field.

PI_NAMEs: DOIRON, BRENT D. (contact);MACLEAN, JASON NEIL;PALMER, STEPHANIE E

PROJECT_TERMS: Appointment;Behavior;Biology;Brain;brain dysfunction;Chicago;Code;Communities;Competence;Complement;computational neuroscience;computer science;Computers;Data;Data Set;Discipline;Doctor of Philosophy;Dryness;Educational Status;Electronics;Engineering;Ensure;Environment;experience;experimental study;Exposure to;Faculty;Fostering;Funding;Genetic;graduate student;Human;Interdisciplinary Study;Journals;Laboratories;laboratory experiment;Mathematics;Microscopy;Minor;Minority Recruitment;Modeling;National Research Service Awards;neural;Neurobiology;neuromechanism;Neurons;Neurosciences;Neurosciences Research;next generation;programs;Psychology;Research;Research Personnel;Research Project Grants;responsible research conduct;Schools;Series;Statistical Methods;statistics;Students;summer program;System;Teacher Professional Development;Techniques;theories;Training;Training Programs;undergraduate research experience;undergraduate student;Universities;Work

PROJECT_TITLE: Training in Theory and Computation for Next Generation Neuroscientists


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative There is an urgent need for novel therapeutic approaches to treat chronic pain, however a major hurdle is the lack of detailed understanding of nociceptive circuitry. Our premise is that spinal cord nociceptive circuit outputs to the brain are attractive targets because pain-related signals emanating from a range of nociceptors and other sensory neuron types, descending modulatory inputs, and local interneurons, channel through only a limited number of ascending outputs pathways. Our plan is to use new mouse genetic tools and physiological and behavioral analyses to reveal the properties and functions of dorsal horn nociceptive circuit output pathways to generate a new predictive model of spinal cord nociceptive circuitry as a foundation for developing alternatives to opioids as analgesics.

PI_NAMEs: DRUGOWITSCH, JAN ;GINTY, DAVID D (contact);WOOLF, CLIFFORD J

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Acute;Address;Affective;Afferent Neurons;Analgesics;Anatomy;Animals;Anterolateral;awake;Behavior;Behavioral;behavioral response;Brain;Brain imaging;Brain region;Brain Stem;Chemicals;chronic pain;chronic pain management;Cutaneous;Disease;dorsal horn;Foundations;G-Protein-Coupled Receptors;Genetic;glucocorticoid-induced orphan receptor;Goals;Image;in vivo;inflammatory pain;Interneurons;Language;Lateral;Logic;Mechanics;midbrain central gray substance;Modeling;Morphology;mouse genetics;Mus;Neurons;Nociception;Nociceptors;novel;novel therapeutic intervention;novel therapeutics;Opioid;Output;Pain;pain behavior;pain chronification;pain perception;painful neuropathy;parabrachial nucleus;Pathway interactions;Physiological;Pilot Projects;Population;predictive modeling;prevent;Property;Pruritus;Reaction;response;Sensory;sensory input;Signal Transduction;Spinal Cord;Spinal cord posterior horn;Stimulus;superior colliculus Corpora quadrigemina;Synapses;TACR1 gene;Temperature;Testing;Thalamic structure;tool;Touch sensation;Work

PROJECT_TITLE: Spinal Cord Nociceptive Circuits that Deliver Outputs to the Brain to Initiate Pain


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Psychological distress and depression are common among young people living with HIV (Y-PLWH) and negatively impact medication adherence and disease control. In low- and middle-income countries, this problem is compounded by the lack of trained mental health professionals on the provider side and the requirement of frequent clinic-based visits imposing greater cost, inconvenience, and stigma for patients. In this proposal, we will 1) finalize the prototype of Change My Story, a narrative digital game with a choose-your- own-adventure format in which young players navigate difficult experiences based on drivers of psychological distress and depression and 2) integrate this game into a comprehensive, task-shifted PST intervention to optimize engagement in mental health care to improve treatment outcomes.

PI_NAMEs: AHONKHAI, AIMALOHI  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Adopted;Africa;Africa South of the Sahara;African;age group;antiretroviral therapy;Appointment;care providers;Caregivers;Caring;Cause of Death;Cellular Phone;Climate;Clinic;comorbidity;Consolidated Framework for Implementation Research;cost;Country;COVID-19;design;Development;Diagnosis;digital;Disease remission;disorder control;Distress;Effectiveness;effectiveness-implementation RCT;effectiveness/implementation hybrid;Emotional;epidemic response;Epidemiology;evidence base;experience;Exploratory/Developmental Grant;Friends;Funding Opportunities;Future;General Population;Goals;handheld mobile device;Health;Health Professional;Health Promotion;Health Services Accessibility;Health Technology;HIV;Home;implementation barriers;implementation science;improved;Individual;innovation;Interdisciplinary Study;interest;Intervention;intervention delivery;Knowledge;low and middle-income countries;medication compliance;Mental Depression;Mental disorders;Mental Health;Mental Health Services;mental training;mHealth;multidisciplinary;Nigeria;Nonprofit Organizations;novel;Outcome;Ownership;Patients;Persons;Play;Population;problem solving therapy;prototype;Provider;Psychiatric Social Work;psychologic;psychological distress;Psychotherapy;Public Health;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Role;satisfaction;screening;Side;social cognitive theory;Social Impacts;social stigma;stakeholder perspectives;Technology;telephone based;Testing;theories;Therapeutic Intervention;Training;Treatment outcome;Universities;usability;virtual environment;Visit;World Health Organization;Youth

PROJECT_TITLE: An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Leukemia;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Nutrition;Obesity;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Excessive weight gain leading to obesity is common during the early phases of pediatric acute lymphoblastic leukemia (ALL) treatment, and results in higher risk of relapse, lower event-free survival rates, and more adverse events during treatment. To address multiple calls from the NCI and other federal agencies for research targeting disparities in treatment outcomes among patients who experience obesity, this K08 research will adapt, refine, and pilot test family-based health promotion intervention that aims to curb excessive weight gain among youth with newly diagnosed ALL. The proposed research and career development plan will yield important patient- centered data regarding components of intervention adaptation, feasibility, acceptability, and participant engagement, enhancing the potential for the investigator to advance behavioral cancer control science and improve clinical outcomes for youth with ALL.

PI_NAMEs: BATES, CAROLYN R (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Acute Lymphocytic Leukemia;Address;Adverse event;arm;behavior change;Behavior Therapy;Behavioral;Behavioral Model;Cancer Control;cancer diagnosis;Cancer Survivor;career;career development;Child;Child Health;Childhood Acute Lymphocytic Leukemia;Childhood Cancer Treatment;Chronic;Clinical;clinical practice;Clinical Trials;Cognitive;Cognitive Therapy;Conduct Clinical Trials;coping;Coping Skills;Data;design;Development Plans;Diagnosis;Dietary intake;Disease-Free Survival;Disparity;Dose;Eating;Education;efficacy testing;efficacy trial;Eligibility Determination;Enrollment;Environment;evidence base;excessive weight gain;experience;Family;family structure;family support;Feedback;follow-up;Future;Glucocorticoids;Goals;Health;Health behavior;Health Promotion;healthy weight;high risk;improved;Intervention;intervention refinement;Interview;Knowledge;leukemia treatment;Malignant Childhood Neoplasm;Malignant Neoplasms;Mentorship;Modeling;multidisciplinary;Newly Diagnosed;Obesity;Outcome;Participant;patient engagement;patient oriented;Patients;Pharmaceutical Preparations;Phase;Physical activity;physical inactivity;pilot test;Play;Preparation;prevent;preventive intervention;Process;Prognosis;Protocols documentation;recruit;relapse risk;Research;research and development;Research Personnel;retention rate;Role;Scientist;sedentary;Sepsis;Shapes;skill acquisition;skills;Stress;Stress and Coping;stress management;stressor;Structure;Survival Rate;survivorship;System;Targeted Research;Testing;therapy development;Time;Toxic effect;Training;treatment disparity;Treatment outcome;Treatment Protocols;Unhealthy Diet;Weight;Weight Gain;weight gain prevention;Work;Youth

PROJECT_TITLE: A Healthy Weight Intervention for Family Stress during the Early Phases of ALL Treatment: NOURISH-ALL

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy;Lupus

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative:  Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by autoantibodies that continue to spread to new self-antigens over time resulting in increased pathogenesis and disease. We propose that this phenomena, referred to as epitope spreading, is promoted by a specialized subset of autoreactive B cells that originate from both spontaneous GC and non-GC lymphoid space. In the current proposal, we will characterize the developmental kinetics and dynamics of this subset and how their fates are determined by the two different environments.

PI_NAMEs: CARROLL, MICHAEL CRAIG (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Adoptive Transfer;Affinity;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive B cell;autoreactivity;B-Lymphocytes;CD11 Antigens;Cell surface;Cells;Chimera organism;Clone Cells;Complement 3d Receptors;Complement Receptor;CXCR3 gene;Development;Disease;Effector Cell;Environment;Epitope spreading;Epitopes;Event;Evolution;Genetic;Health;humoral immunity deficiency;Immunoglobulin-Secreting Cells;ITGAX gene;Kinetics;Longitudinal Studies;Lupus;Lymphoid;Malpighian corpuscles;Mediating;migration;Modeling;mouse model;Mus;mutant;novel;Nuclear Antigens;Pathogenesis;pathogenic autoantibodies;Pathology;Patients;Peptides;Phenotype;Population;Regulation;Reporting;response;Role;Site;Specificity;Structure of germinal center of lymph node;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Time;transcriptomics

PROJECT_TITLE: Evolution of autoreactive GC and epitope spreading in lupus

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses the unmet needs for tailored guidelines to manage genital infections, and for accessible sexual and reproductive health care, among Syrian refugee women, who constitute the world's largest and most vulnerable forcibly displaced female population. By quantifying and characterizing drivers of recurrent genital infections, we seek to develop contextualized prevention and management tools to be incorporated into an adapted and evidence-based sexual health intervention for rural-dwelling refugee women in Lebanon. The novel application of implementation science methodologies to improve refugee women's health in a humanitarian setting is directly responsive to the Fogarty International Center's goal to “catalyze timely, high-quality, ethical, and actionable research in crisis settings”, and may inform global responses to the growing refugee crisis with potential to improve the lives of millions of forcibly displaced women in resource-limited, humanitarian settings.

PI_NAMEs: FAHME, SASHA  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acute;Address;American;Appointment;Area;Bacterial Vaginosis;barrier to care;career;career development;Caring;Cervical Cancer Screening;Chlamydia trachomatis;chronic pain;Client;Clinic;Clinical;Cluster randomized trial;Cohort Studies;Communities;Consult;Continuity of Patient Care;Cross-Sectional Studies;Data;data integration;Diabetes Mellitus;Diagnostic tests;dissemination science;Education;Educational workshop;effectiveness study;Environment;Epidemiology;Ethics;Etiology;evidence base;Evidence based intervention;experience;Feasibility Studies;Female;Fogarty International Center;Fostering;Fright;Gender;Gender Identity;genital infection;Genitalia;Goals;Grant;Guidelines;Health;health disparity;health science research;Health Services Accessibility;Healthcare;HIV;Human immunodeficiency virus test;Hybrids;Hygiene;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;Infection;Infection prevention;Infertility;Internal Medicine;International;Internist;Intervention;intervention refinement;Interview;Leadership;Learning;Lebanon;low health literacy;maltreatment;Master of Science;Measures;Medical;medical schools;Medicine;Mentors;Mentorship;Methodology;Methods;Modeling;Neisseria gonorrhoeae;New York;novel;obstetrical complication;Outcome;Outcome Assessment;Participant;Pathogen detection;peer;Peru;Physicians;pilot test;Population;Positive Test Result;prevent;Prevention;Provider;Public Health;recruit;Recurrence;recurrent infection;Refugees;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;response;Retreatment;Risk;Risk Factors;Rural;rural area;rural residence;rural setting;Sampling;satisfaction;Scientist;Self Efficacy;Service provision;sex;sexual and reproductive health;Sexual Health;sexual health intervention;sexual risk behavior;Sexually Transmitted Diseases;skill acquisition;skills;symposium;Symptoms;systematic review;Testing;tool;Training;Translating;transmission process;Trichomonas vaginalis;Underserved Population;Universities;virtual;Vulvovaginal Candidiasis;Woman;Women's Health;Writing

PROJECT_TITLE: Genital Infection Symptoms Among Syrian Refugee Women in Lebanon: A Mixed-Methods Study to Adapt, Pilot Test, and Preliminarily Evaluate an Evidence-Based Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-P(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The Oncology-focused Postdoctoral Training In Care Delivery and Symptom Science (OPTICS) T32 program will train postdoctoral fellows (MDs and PhDs) to conduct innovative translational research to decrease cancer mortality by improving cancer care delivery. The program's cornerstone will be a 2-year mentored research experience in which trainees will I) execute an impactful research project aligned with one or more of four cancer-focused thematic areas: (1) Data Science, (2) Risk Mitigation, (3) Symptom Science, and (4) Care Delivery; II) train in core research methods through coursework, seminars, workshops, and reading groups; and III) acquire the professional skills prerequisite for success as independent investigators. OPTICS trainees will benefit from Memorial Sloan Kettering Cancer Center's large patient population, diverse faculty mentors, data assets, New York City location, and close partnership with Weill Cornell Medicine and Rockefeller University, as well as its vibrant culture dedicated to population health, training, and scientific discovery through collaborative multidisciplinary team science.

PI_NAMEs: BERNSTEIN, JONINE L.;MAO, JUN J;PANAGEAS, KATHERINE S (contact);SCHRAG, DEBORAH

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: care delivery;Oncology;post-doctoral training;symptom science

PROJECT_TITLE: Oncology-focused Postdoctoral Training in Care Delivery and Symptom Science (OPTICS)

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE The ability to precisely target individuals with cancer and at-risk populations with evidence-based tools to address individual, sociocultural, or environmental factors is likely to lead to the greatest improvements in cancer outcomes and reductions in cancer risk. Thus, this application for a new T32 postdoctoral training program at Fox Chase Cancer Center is designed to prepare PhD and MD postdoctoral fellows to lead innovative and scientifically rigorous research in precision cancer control with diverse populations.

PI_NAMEs: FANG, CAROLYN Y. (contact)

PROJECT_TERMS: Cancer Control;Grant;Training

PROJECT_TITLE: Training Grant in Precision Cancer Control


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE The proposed U01 consortium will expand long-standing work centered at the NIH Clinical Center focused on individuals with germline GATA2- or RUNX1-mutations who are at high-risk for developing bone marrow failure (BMF) and hematopoietic malignancies (HMs). Intramural and four extramural investigators will test the hypothesis that inflammation derived from intrinsic and extrinsic sources drives BMF in GATA2-mutant patients, plus clonal hematopoiesis that frequently evolves into HMs in both syndromes. The results of the planned work will identify new biomarkers and pathways associated with BMF and HMs and lead to novel strategies to lower systemic inflammation and slow or prevent clonal expansion that could be tested in a clinical trial.

PI_NAMEs: AGARWAL, ANUPRIYA ;BRESNICK, EMERY H;GODLEY, LUCY ANN (contact);SPECK, NANCY

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acceleration;acute infection;Acute T Cell Leukemia;Adolescent;Age;Automobile Driving;B lymphoid malignancy;B-Lymphocytes;Benchmarking;Benign;Biological Assay;biomarker identification;Blood Platelets;Bone marrow failure;Cell Differentiation process;cell growth;Cell Line;Cells;Characteristics;chemokine;Chicago;chronic infection;Classification;Clinic;Clinical assessments;clinical center;Clinical Trials;Clonal Expansion;Collection;Country;cytokine;Data;Defect;Dendritic Cells;derepression;design;Development;Differentiation and Growth;Disease;driver mutation;Drug usage;Dysmyelopoietic Syndromes;Extramural Activities;Family;GATA2 deficiency;Gene Mutation;General Population;Germ Lines;Growth;Health;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;Hematopoietic stem cells;high risk;Immune;immunodeficiency;improved;In Vitro;Individual;Infection;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Inherited;innovation;interest;Laboratories;leukemia;leukemogenesis;Ligands;Malignant Neoplasms;Mesenchymal Stem Cells;mesenchymal stromal cell;monocyte;Monosomy 7;mouse model;Mus;mutant;Mutation;mutation carrier;Mycoses;Myeloproliferative disease;Natural Killer Cells;non-tuberculosis mycobacteria;novel strategies;Oregon;Pathogenicity;Pathway interactions;Patients;Pennsylvania;Pre-Clinical Model;Predisposition;prevent;programs;research clinical testing;Research Personnel;response;Risk;Role;RUNX1 gene;Sampling;Science;Signal Transduction;Somatic Mutation;Source;stem cell growth;Syndrome;systemic inflammatory response;Testing;TLR4 gene;transcription factor;Translational Research;United States National Institutes of Health;Universities;Variant;variant of unknown significance;Viral;Wisconsin;Work;Xenograft procedure

PROJECT_TITLE: The role of inflammation in driving leukemogenesis in germline predisposition syndromes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PUBLIC RELEVANCE Ensuring adherence to cognitive training in unsupervised circumstances in older adults at risk for AD/ADRD may help promote the usage and benefit of cognitive training in slowing cognitive decline and AD/ADRD progression.

PI_NAMEs: ADELI, EHSAN ;LIN, FENG VANKEE (contact);TAPPARELLO, CRISTIANO

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;application programming interface;Attention;Behavioral;behavioral impairment;Boredom;Cognitive;cognitive benefits;cognitive change;cognitive training;computerized;Data Collection;deep neural network;dementia risk;design;Detection;efficacy study;Enrollment;Ensure;Equilibrium;Face;Facial Expression;Fatigue;follow-up;Frustration;Future;future implementation;Goals;Home;Impaired cognition;improved;Infrastructure;Intervention;Learning;Libraries;Measures;Mental Depression;Mental Fatigue;mild cognitive impairment;Monitor;novel;older adult;Participant;Pattern;Performance;Periodicals;Physiological;post intervention;processing speed;Randomized, Controlled Trials;Readiness;recruit;Resolution;response;Sampling;satisfaction;Self Administration;sensory input;Signal Transduction;sustained attention;Testing;Time;Training;Training Programs;Treatment Efficacy;Work

PROJECT_TITLE: A facial expression-based personalization engine (FPE) for monitoring and modulating real-time effective engagement in cognitive training in older adults at risk for AD/ADRD


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Wound Healing and Care

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This research is relevant to public health because understanding the prevalence, risk factors, knowledge, and harm reduction practices associated with xylazine use and the development of wounds will inform practice and raise awareness among the affected communities, health care and harm reduction service providers and the public regarding the health risks associated with xylazine. This mixed methods project is responsive to PAR- 22-027 as it will generate time-sensitive knowledge in response to a sudden and severe emerging drug issue. The results of this study will directly contribute to preventing the harmful consequences associated with xylazine emergence.

PI_NAMEs: GENBERG, BECKY LYNN;GERMAN, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Abscess;Affect;Animals;Awareness;Baltimore;Behavioral;Belief;Cessation of life;Characteristics;cohort;Collaborations;Communities;Country;Data;Dedications;Development;Discrimination;drug testing;Drug usage;Drug user;Enrollment;Ensure;Epidemiology;epidemiology study;experience;Fentanyl;Geographic Locations;Geography;Goals;Government Agencies;Harm Reduction;Health;Health Services Accessibility;Healthcare;Healthcare Systems;Heroin;HIV;HIV Infections;Illicit Drugs;improved;Infectious Skin Diseases;Injecting drug user;Injections;Intervention;Interview;Knowledge;Location;Maryland;medical attention;Medical Examiners;Methods;Mid-Atlantic Region;mortality;Naloxone;Necrosis;non-opioid analgesic;Opioid;opioid overdose;Outcome;Overdose;overdose death;overdose risk;peer;Persons;Pharmaceutical Preparations;Prevalence;prevent;Prevention strategy;Provider;Public Health;Puerto Rico;Qualitative Methods;Recording of previous events;recruit;Reporting;Research;Respondent;response;Risk;Risk Factors;Sampling;sedative;service providers;Services;Site;social stigma;Soft Tissue Infections;stem;surveillance study;Surveys;Time;Translating;treatment program;wound;wound care;Wound Infection;Xylazine

PROJECT_TITLE: Rapid Research for Xylazine Response


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Regenerative Medicine;Transplantation

ORG_CITY: HOUGHTON

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Although the bioengineered human corneal endothelial grafts have shown vision recovery in animal models, the current grafts do not provide native-like reconstruction of the cornea due to suboptimal degradation of the biomaterial in the eye, which has hindered further development of this technology for corneal patients. The proposed research is relevant to public health because it develops a new biomaterial that can be dissolved from the outside after transplantation, thereby enabling improving corneal reconstruction. Upon completion, this research will improve the current corneal endothelial grafts for corneal patients and is in line with NIH’s mission of improving the quality of life.

PI_NAMEs: RIZWAN, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Adhesions;Animal Model;Anterior;anterior chamber;Basement membrane;Biocompatible Materials;Biological Assay;biomaterial compatibility;Biomedical Engineering;Biomimetics;Cell Maturation;Cell Physiology;Cell Transplantation;Cell-Cell Adhesion;Cells;Cornea;Corneal Diseases;Corneal Endothelium;Cues;cyanine dye;Deposition;design;Development;Devices;disease model;Donor person;Endothelial Cells;Engineering;Engraftment;Evaluation;Exposure to;extracellular;Extracellular Matrix;Eye;Failure;Film;Gelatin;graft function;Growth;high throughput analysis;Histologic;Hour;Human;human stem cells;Hydrogels;Image;Image Analysis;improved;In Vitro;in vivo;innovation;K ATPase;Keratoplasty;Kinetics;Label;Light;lithography;Measurement;Mechanics;Metabolic;Methacrylates;Mission;Modeling;Modulus;monolayer;Morphology;nanopattern;Nanotopography;Organ Culture Techniques;Oryctolagus cuniculus;Patients;Persons;Physiologic Intraocular Pressure;Pilot Projects;Procedures;progenitor;Proliferating;Public Health;Quality of life;reconstruction;Recovery;Research;response;Surgeon;Technology;technology development;Tissue Engineering;Tissues;tool;Transplantation;two-photon;United States National Institutes of Health;Vision;Waiting Lists;Work;Yam - dietary

PROJECT_TITLE: Bioengineered corneal endothelial graft using photodegradable device to induce graft-host integration

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pain Research;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The proposed project is of public health importance because children with intellectual and developmental disabilities are at increased risk for having their pain missed or under-treated. Parents play an important role in judging when their children are in pain and when that pain needs to be treated, but little is understood about what factors influence these judgments among parent-child dyads affected by intellectual and developmental disabilities. The proposed study will identify the reciprocal parent and child factors that influence how children with intellectual and developmental disabilities express pain and how parents interpret and respond to these pain behaviors, with a long term goal of improving pain assessment and treatment.

PI_NAMEs: BYIERS, BREANNE J (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Adaptive Behaviors;Affect;Age;Anxiety;Behavior;Behavioral;behavioral response;Belief;Biological Factors;Blood;Categories;Child;Childhood;Clinical;clinically relevant;Cognition;Communication;Cues;Diagnosis;disability;Disparity;disparity reduction;Event;Exhibits;Expectancy;experience;Face;Facial Expression;Family;Foundations;General Population;global developmental delay;Goals;Guidelines;health goals;improved;Individual;Intellectual functioning disability;Judgment;Knowledge;Lead;Learning;Learning Disabilities;limb movement;Longitudinal Studies;Measures;Modeling;Morbidity - disease rate;mortality;Motor;motor deficit;negative affect;novel;Outcome;Pain;pain behavior;pain catastrophizing;Pain intensity;Pain management;Pain Measurement;pain model;pain score;pain sensitivity;Parent-Child Relations;parental influence;Parents;Patient Self-Report;peer;Perception;Play;Process;Proxy;Psychological Factors;psychosocial;Psychosocial Factor;Public Health;Recording of previous events;recruit;Reporter;Reporting;response;Risk;Role;Sampling;Shapes;social communication;social factors;social influence;Social Processes;Source;standard of care;Standardization;System;Testing;Variant;Venipunctures;verbal;Video Recording;vocalization;Work

PROJECT_TITLE: Dyadic parent-child influences on pain expression and proxy ratings in children with IDD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: LEE, DAEYEOL ;MURRAY, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: adaptive learning;Algorithms;Animals;Architecture;Artificial Intelligence;artificial neural network;autism spectrum disorder;base;Behavior;behavior prediction;Behavioral;Biological;Brain;Categories;Choice Behavior;Code;computational neuroscience;Computer Models;computer studies;Corpus striatum structure;Data;Data Set;design;Dorsal;Evolution;experience;experimental study;feedforward neural network;flexibility;Goals;Human;Impairment;insight;Intelligence;kernel methods;learned behavior;Learning;Light;Link;Machine Learning;Modeling;neural;neural network;Neural Network Simulation;Neurobiology;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;Neurosciences;nonhuman primate;novel;Population;Prefrontal Cortex;Primates;Process;Property;recurrent neural network;Research;Schizophrenia;Shapes;statistics;Stimulus;success;Task Performances;Testing;Training;translational applications

PROJECT_TITLE: CRCNS: Neural Basis of Inductive Bias


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative

ORG_NAME: UNIVERSITY CITY SCIENCE CENTER

PHR: National Institute on Aging (NIA) REDI Skill for ENtrepreneurs for Elder Solutions (SENES) fellowship program  Project Narrative SENES is a year-long educational experience that will provide a five-founder cohort (annually; 25 over five years) with six months of hands-on learning punctuated with an “elder solutions” capstone project in month six. The second six months of the fellowship will be an active and supported technology translation in one of two tracks, all supported by medical faculty and aging-focused advisors as well as the experienced commercialization team at UCSC. SENES will expose founders to the aging market for their solutions in a practical and material way; position founders for success in their commercialization efforts, resulting in more successful technology-based startups from NIH-funded and supported researchers; and leverage government investment by increasing the likelihood of success of private capital.

PI_NAMEs: NAQUIN, HEATH  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Applied Research;Area;Awareness;Basic Science;Capital;career;Career Choice;Cities;Cognitive;cohort;commercial application;commercialization;Doctor of Philosophy;Economics;Education;Elderly;Entrepreneurship;Environment;Evaluation;experience;Exposure to;Fellowship;Fellowship Program;Funding;Future;Government;hands-on learning;Incubated;innovation;Institution;interest;Investments;Knowledge;literacy;Marketing;Measures;Medical;Medical Faculty;Modeling;National Institute on Aging;Outcome;Participant;Positioning Attribute;Privatization;programs;research and development;Research Personnel;Research Project Grants;Science;skills;Small Business Innovation Research Grant;student participation;Students;success;Technology;Technology Transfer;Thinking;tool;Training;Translational Research;Translations;United States National Institutes of Health;Universities;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Despite the rapidly growing population of older Chinese Americans, their participation in clinical trials for Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) remains historically low due to a lack of culturally and linguistically appropriate study materials and assessment tools. The Memory Support System (MSS) from the Healthy Action to Benefit Independence & Thinking® (HABIT) Program is a promising non-pharmacological intervention for individuals with mild cognitive impairment, but the system was primarily developed and used on non-Hispanic White, English-speaking adults. Translation and adaptation of the MSS materials and assessment tools from English into Chinese, the third most spoken language in the US, will help create clinical trial opportunities for older Chinese Americans and collect the pilot data needed to conduct a larger non-pharmacological intervention targeting early symptoms of AD/ADRD.

PI_NAMEs: LI, CLARA  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Adherence;Adult;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;Asian Americans;Assessment tool;associated symptom;bilingualism;Calendar;Caregiver Burden;Caregivers;Chinese;Chinese American;Chronic;Clinical;Clinical Research;clinical translation;Clinical Trials;Cognition;Cognitive;cognitive testing;cohort;Collaborations;Communities;community based participatory research;Control Groups;daily functioning;Data;Dementia;design;Development;Early Intervention;Early treatment;Education;Effectiveness;efficacy evaluation;English Language;Enrollment;ethnic diversity;Ethnic Population;evidence base;Exclusion;experience;Feedback;Focus Groups;follow-up;functional decline;Functional impairment;Goals;Impaired cognition;improved;Independent Living;Individual;instrumental activity of daily living;Intervention;Language;Learning;Life;Limited English Proficiency;Linguistics;Measures;Memory;Mental Depression;mild cognitive impairment;Moods;Neurobehavioral Manifestations;neuropsychiatric symptom;non-demented;Nonpharmacologic Therapy;Not Hispanic or Latino;older adult;Older Population;Participant;Persons;Pharmacological Treatment;Population;preservation;Prevention;Prevention trial;primary outcome;programs;Quality of life;Race;randomized trial;Randomized, Controlled Trials;recruit;Registries;Reporting;Research;Research Methodology;retention rate;Risk;Sample Size;Sampling;satisfaction;Self Efficacy;Serious Adverse Event;Site;Spanish/English;success;Support System;symptom treatment;Symptoms;System;Testing;Thinking;Training;Translating;Translations;treatment adherence;Writing

PROJECT_TITLE: A Pilot of Memory Support System for Older Chinese Americans with Mild Cognitive Impairment

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Drug Abuse (NIDA only);Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The effects of recreational cannabis legalization (RCL) on use of cigarettes, cigars, and electronic nicotine delivery systems (ENDS)—the US’s three most popular tobacco/nicotine products—are unclear and understudied, despite potentially substantive public health implications due to tobacco’s longstanding role as the US’s leading cause of preventable morbidity and mortality. Collecting detailed information on state and local cannabis policies and retail environments and matching these to nationally representative survey data, this project will clarify how these regulations impact underage and adult use of cigarettes, cigars, ENDS, and blunts as well as cannabis use, assess how state policy details and local cannabis laws modify these effects, and simulate the impacts of alternative policy scenarios for tobacco product use by age-group. Findings will clarify RCL’s effects on tobacco/nicotine use and identify cannabis policy opportunities at the federal, state, and local level to ensure continued progress towards eliminating tobacco’s toll on society.

PI_NAMEs: FRIEDMAN, ABIGAIL S. (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: 20 year old;Acceleration;Accounting;Address;Adult;Affect;Age;age group;Attention;Behavior;Cannabis;Cannabis policy;Cannabis retail;Cigar;Cigarette;cigarette smoking;Communities;Community Health;Complement;cost;Costs and Benefits;Data;Databases;density;District of Columbia;Drug usage;Economics;Electronic Nicotine Delivery Systems;Elements;Ensure;Environment;Epidemic;expectation;Formulation;geographic difference;Goals;Health;health data;Heterogeneity;Home;improved;Laws;Legal;legal implication;Licensing;Link;Literature;marijuana legalization;marijuana use;marijuana use disorder;Methods;Modeling;Modification;Morbidity - disease rate;mortality;Nicotine;nicotine use;non-cigarette tobacco product;Patient Self-Report;Pattern;Peer Review;Persons;Policies;Policy Maker;Policy Research;preempt;Prevalence;preventable death;Prevention;Price;Proxy;Public Health;public policy on tobacco;Quasi-experiment;Randomized;Recreation;Regulation;Research;Role;Sales;simulation;Smoker;Smoking;Societies;sociodemographics;Structure;success;Surveys;Taxes;Testing;THC concentration;theories;Time;Tobacco;tobacco control;tobacco products;Tobacco use;tool;Variant;Work;young adult;Youth

PROJECT_TITLE: Cannabis Legalization's Effects on Youth and Adult Nicotine and Tobacco Use

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: PROJECT NARRATIVE The Mayo Advancing Research Equity in ADRD Study in Jacksonville (MAREAS-Jax; Spanish for tides) will support the development of infrastructure to recruit and engage Hispanic/Latino Americans and African Americans in a longitudinal research program designed to characterize the contributions of genetic, medical comorbidities, and lifespan influences of Structural/Social Determinants of Health (the “exposome”) to disparate burden of Alzheimer disease and related dementias. Real-time communication of brain health risk factors will empower participants to mitigate risks and improve overall brain health. Neuroimaging and blood-based biomarkers of amyloid, tau, neurodegeneration, and vascular burden together with multi-omics measures will inform the relationship between the exposome and Alzheimer disease and related dementia burden within and across individuals.

PI_NAMEs: CARRASQUILLO, MINERVA MARIA;LACHNER, CHRISTIAN  (contact);WHITE, RICHARD O

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Advisory Committees;African American;African American population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-42;bilingualism;Biological;Biological Factors;Biological Markers;biomarker identification;biomarker signature;Blood;Blood Vessels;blood-based biomarker;Brain;brain health;burden of illness;caucasian American;Censuses;cerebrovascular;Clinic;Clinical;Cognitive;cohort;Committee Members;Communication;Communities;Community Participation;comorbidity;Data;data analysis pipeline;Data Collection;data sharing;Dementia;dementia burden;dementia risk;design;Development;Disease;Disparate;disparity elimination;disparity reduction;DNA;Education;empowerment;Equity;Evaluation;Exposure to;FAIR principles;Feedback;Florida;Focus Groups;Genetic;Genomics;Glial Fibrillary Acidic Protein;Goals;Guidelines;Health;Health behavior;health determinants;health disparity;High Prevalence;Hispanic;Hispanic Populations;imaging biomarker;improved;Individual;individualized feedback;Infrastructure;infrastructure development;Institution;Investments;Knowledge;Latino;Latino Population;life span;Life Style;Light;Link;Measurable;Measures;Medical;modifiable risk;Modification;Molecular;Molecular Profiling;Molecular Target;Multiomic Data;multiple omics;Nerve Degeneration;neurofilament;neuroimaging;Not Hispanic or Latino;novel;Outcome;outreach;Participant;personalized strategies;Phase;Plasma;Policies;Population;Positron-Emission Tomography;pre-clinical;programs;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Risk Factors;risk mitigation;Risk Reduction;RNA;Sampling;social;Social Environment;social health determinants;Social Processes;Spanish;Spanish/English;Standardization;Systems Biology;tau Proteins;Time;United States;United States National Institutes of Health

PROJECT_TITLE: Mayo Advancing Research Equity in ADRD Study in Jacksonville(MAREAS-Jax)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Palliative Care;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors (ICIs) use body's own immune response to fight cancer. Because immune response is generally stronger in patients of African ancestry (AA) than European ancestry (EA), AA patients may have more negative side effects from ICIs but may also respond better to them. In this study, we will follow a large group of AA and EA patients on ICIs over time in order to understand these racial differences and to see what other patient factors may predict these differences. The long-term goal is to ensure that all patients can benefit from new treatments for their cancer through appropriate management of side effects.

PI_NAMEs: KAMEN, CHARLES STEWART;YAO, SONG  (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;African ancestry;Aftercare;anti-cancer research;anti-PD-1;anti-PD-1/PD-L1;B-Lymphocytes;Behavioral;Cancer Patient;cancer site;Cancer Survivor;cancer therapy;cancer type;Cessation of life;checkpoint therapy;Clinical Trials;cohort;Cohort Studies;Community Clinical Oncology Program;cost;Data;design;Diagnosis;Discrimination;Disease;disorder subtype;Disparity;Drops;Enrollment;European ancestry;exhaust;experience;fighting;financial toxicity;Frequencies;Funding;Goals;health care availability;health related quality of life;Healthcare;high risk;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunity;Immunotherapy;Incidence;Individual;Inflammatory;Inflammatory Response;innovation;Insurance;Interruption;Knowledge;Life Style;lifestyle factors;Link;Long-Term Effects;Malignant Neoplasms;minority patient;Modality;mortality;objective response rate;Outcome;Patient-Focused Outcomes;Patients;Population;programmed cell death protein 1;programs;Prospective cohort;Prospective, cohort study;psychological distress;Quality of life;racial difference;Recurrence;Research;response;Safety;Severities;Shapes;side effect;Site;social health determinants;standard of care;T-Lymphocyte;Time;Tissues;Toxic effect;Treatment outcome;treatment pattern;treatment response;tumor;tumor microenvironment;uptake

PROJECT_TITLE: Disparities in REsults of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated with anti-PD-1/anti-PD-L1 in a Community Oncology Setting


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal is to support a unique program of predoctoral training in Cancer Biology at Emory University. A suite of evidence-based learning approaches, experienced research mentors, and a unique ability to interact across clinical and laboratory disciplines will enable the development of our Ph.D. level workforce in academic, industry, and government-based research careers, as well as other biomedical research-related careers to enhance understanding the biology of cancer and ultimately reach a cancer-free world. This proposal will ensure appropriate training in rigor and reproducibility, methods to assessing student competencies, and a focus on inclusive excellence to train a diverse cadre of Ph.D. scientists capable of cross-disciplinary communication.

PI_NAMEs: KANG, SUMIN ;LESINSKI, GREGORY B. (contact)

PROJECT_TITLE: Graduate Program in Cancer Biology Training at Emory University


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: CONTRALINE, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE There are no effective, long-acting reversible male contraceptives commercially available. Contraline has developed a long-lasting, non-permanent, injectable hydrogel (ADAM) to occlude sperm transport in the vas deferens, which has demonstrated safety and efficacy in a First-in-Human clinical study. This SBIR proposal focuses on the development of a next-generation implantable male contraceptive (ADAM Air) that is simpler to implant and reverse than previous vas-occlusive contraceptives, and demonstration of its safety and efficacy via GLP studies to allow Contraline to pursue future clinical trials.

PI_NAMEs: TROPSHA, YELENA  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: absorption;Acne;Air;Animal Model;aqueous;biomaterial compatibility;birth control;Board Certification;Cadaver;Canis familiaris;Chemicals;Clinical;clinical development;Clinical Research;Clinical Trials;commercialization;condoms;Contraceptive Agents;Contraceptive Availability;Contraceptive Devices;Contraceptive methods;Contraceptive Usage;cost;Couples;cytotoxicity test;Dedications;Dehydration;Desiccation;design;Development;Devices;Diameter;Doctor of Philosophy;dosage;Ejaculatory duct structure;Ensure;Evaluation;experience;Family;Female;Female Condoms;Fertility;first-in-human;Formulation;Foundations;Future;Gel;Generations;Goals;Health;Health Care Costs;High Density Lipoprotein Cholesterol;Hormonal;Human;Hydrogels;Implant;implantation;In Vitro;in vivo;in vivo Model;Injectable;Injections;innovation;interest;Intramuscular Injections;Intrauterine Devices;Leadership;Length;life span;Lipids;Liquid substance;Male Condoms;Male Contraceptive Agents;male health;manufacture;Market Research;mechanical properties;Mechanics;Medical;Medical Device;men;Methods;Microsurgery;minimally invasive;Modeling;Modernization;Myalgia;next generation;Ointments;Oral;Oryctolagus cuniculus;Outcome;Pain;Patients;Performance;Phase;pill;point of care;Polycythemia;Pregnancy;Procedures;Property;Protocols documentation;prototype;psychologic;Reporting;Respondent;restoration;reversible contraceptive;Risk Assessment;Risk Reduction;Safety;side effect;Site;Small Business Innovation Research Grant;solid state;Specific qualifier value;sperm cell;Sperm Count Procedure;Sperm Transport;Study models;Surveys;Swelling;Technology;Testing;Testis;Therapeutic;Toxicology;Translations;Travel;unintended pregnancy;Urologist;Vas deferens structure;Vas Occlusions;Vasectomy;Weight Gain;Withdrawal;Work

PROJECT_TITLE: Development of ADAM Air: A Non-Hormonal Vas Occlusive Contraceptive Device

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Princeton

ORG_DEPT: PSYCHOLOGY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative (Parent Grant)  Gender diverse children often experience disparities in mental health and well-being. Further questions concern the stability of their gender as that has implications for medical transitions. The proposed work would examine the role of gender beliefs and self-categorization in predicting mental health and well-being, as well as provide better estimates of rates of stability and change across time in the identities of both cisgender and gender diverse youth.

PI_NAMEs: OLSON, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TITLE: Views of Gender in Adolescence


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Services

PHR: PROJECT NARRATIVE The mission of this Northwestern University Clinical and Translational Science (NUCATS) UM1 proposal is to transform clinical and translational science to improve health for all. NUCATS will continue to serve as a hub for clinical and translational research across Northwestern University and its clinical affiliates, Northwestern Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, and the Shirley Ryan AbilityLab. NUCATS will build upon its exceptional strengths in cross-disciplinary team science and boundary-crossing partnerships to address three Specific Aims: to advance inclusive excellence in our workforce, community partnerships, and research participants (INCLUDE); to harness innovation to enhance entrepreneurship as well as the rigor and reproducibility of research (INNOVATE); and to infuse implementation science into work across the translational continuum in our health system and with community partners (IMPLEMENT).

PI_NAMEs: BECKER, SARA ;D'AQUILA, RICHARD  (contact);YANCY, CLYDE W.

PROGRAM_OFFICER_NAME: RADMAN, THOMAS C

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Artificial Intelligence;career development;Career Mobility;Chicago;Clinical;clinical care;Clinical Research;Clinical Sciences;Collaborations;Communities;community engaged research;community engagement;community partners;community partnership;Complex;Consultations;Data;Data Collection;data quality;data reuse;Development;Discipline;Education;Ensure;Entrepreneurship;Equity;Ethics;Evaluation;Failure;FAIR principles;Funding;Health;Health Services;Health system;Human;implementation evaluation;implementation science;implementation strategy;improved;industry partner;Informatics;Infrastructure;innovation;Institution;Intervention;Laboratories;Leadership;Medicine;Mentors;Mentorship;Methods;Mission;Modeling;Neighborhoods;next generation;novel;open data;Participant;Patients;Pediatric Hospitals;Performance;Population Heterogeneity;Principal Investigator;Process;Productivity;programs;Public Health;recruit;Reporting;Reproducibility;Research;research and development;Research Personnel;Resources;routine practice;Science;Services;social health determinants;Software Framework;Specific qualifier value;Standardization;Structure;Talents;tool;translational impact;Translational Research;translational scientist;Translations;Universities;Work

PROJECT_TITLE: NUCATS CTSA UM1 at Northwestern University

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-9 (01)]


ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Overall Project Narrative The overarching goal of the Washington University Advancing Cancer Control Equity Research through Transformative Solutions Center (WashU-ACCERT) is to advance cancer control equity in the St. Louis region through community engaged multilevel research interventions that address the impact of social determinants of health on adverse cancer control outcomes. Our innovative strategies to promote community partnerships and implement responsive research will position WashU-ACCERT to meaningfully engage with the local communities and implement interventions that will build capacity among scholars and community partners, and benefit our communities, health systems, providers, and people at greater risk of cancer.

PI_NAMEs: COLDITZ, GRAHAM A.;DRAKE, BETTINA F. (contact);JAMES, AIMEE S;SCHMIDT, SPRING

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;Capital;career;Caring;Catchment Area;Characteristics;Communities;community academic partnership;Community Developments;community engaged approach;community engaged research;community engagement;community partners;community partnership;County;Creativeness;data management;Discipline;Dissemination and Implementation;Equity;Ethnic Origin;Funding;Geography;Goals;Grant;Health;health equity;Health equity research;Health system;Healthcare;high school degree;improved;innovation;Institution;intersectionality;Intervention;Investments;Malignant Neoplasms;Measurement;Measures;Medicine;member;Monitor;neoplasm resource;Outcome;Persons;Positioning Attribute;Poverty;practice setting;Process;programs;Provider;Race;Research;Research Methodology;Research Personnel;Resource Sharing;rural counties;rural healthcare;Science;Scientist;social;social health determinants;sociodemographics;synergism;System;therapy design;Thinking;Trust;United States;Universities;Urban Health;Vision;Washington

PROJECT_TITLE: Washington University ACCERT center

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-F (M1)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: DRAKE, BETTINA F. (contact)

PROJECT_TERMS: Accountability;Address;Advanced Malignant Neoplasm;Cancer Control;Cancer Control Research;cancer health disparity;career;Clinical;Collaborations;Communication;Communities;community based participatory research;community engagement;community partners;Creativeness;Discipline;Effectiveness;Elements;Environment;Equity;Evaluation;Feedback;Foundations;Funding;Future;Goals;Guidelines;health equity;Health Services Accessibility;Illinois;Improve Access;Infrastructure;innovation;Intervention;Leadership;Logic;Maintenance;Malignant Neoplasms;meetings;member;Mission;Missouri;Modeling;Monitor;operation;Outcome;Positioning Attribute;Process;Productivity;programs;Public Health;Recording of previous events;Research;Research Personnel;Research Project Grants;response;Scholarship;Science;Scientific Evaluation;Series;Services;social health determinants;Structure;synergism;Time;timeline;Training;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: COLDITZ, GRAHAM A. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Back;Biometry;Cancer Center;Cancer Control;Collaborations;Common Data Element;Communities;community building;community engaged research;community engagement;community partners;Conceptions;Data;Data Analyses;Data Collection;data management;data sharing;design;Development;Ensure;Equity;Ethics;Evaluation;Faculty;Funding;Future;Goals;health equity;Health equity research;Individual;Information Dissemination;innovation;Institution;Institutional Review Boards;Intervention;Journals;Lead;Leadership;Measures;meetings;member;method development;Methods;Monitor;Outcome;Police;Positioning Attribute;Process;Program Research Project Grants;programs;Publications;Qualitative Research;Recording of previous events;Reporting;Research;Research Design;Research Methodology;Research Project Summaries;Resource Sharing;Resources;Schools;skills;social determinants;social health determinants;Surveys;System;tool;Trust;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Research Measures, Methods and Data Management Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: HOUSTEN, ASHLEY  (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Affect;Area;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Patient;cancer surgery;Cancer Survivor;cancer therapy;care burden;care costs;Caring;Clinic;Clinical;Colorectal Cancer;common treatment;Communication;Communities;community collaboration;community engagement;community partners;Control Groups;cost;Cost Sharing;Data;Deductibles;design;Direct Costs;Education;Eligibility Determination;Equity;Ethnic Origin;Evaluation;experience;Facilities and Administrative Costs;Family;Financial Hardship;Financial Support;financial toxicity;Foundations;Geography;Government;Health;health economics;Health Insurance;Health Services Accessibility;Healthcare;implementation science;improved;insight;Insurance;Interdisciplinary Study;intersectionality;Intervention;Intervention Studies;Intervention Trial;Interview;Knowledge;literacy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Mastectomy;Measures;Medicaid eligibility;Medicare;member;Methods;Missouri;Modeling;older patient;Online Systems;Operative Surgical Procedures;organizational readiness;Outcome;Patient Care;patient oriented;patient-level barriers;Patients;Personal Satisfaction;Persons;prevent;primary outcome;Privatization;Probability;programs;prostate cancer survivors;Provider;Quality of life;Race;racial diversity;Randomized;randomized trial;Recommendation;recruit;Reporting;Research;Research Project Grants;Resources;routine care;Rural;secondary outcome;Self Efficacy;Services;Site;social health determinants;socioeconomics;Structure;Survivors;survivorship;System;tool;Training;Treatment Cost;Uninsured Medical Expense;Universities;Update;Washington;web-based tool;Work

PROJECT_TITLE: Social Determinants of Health Research Project


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: JAMES, AIMEE S (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Area;Back;Cancer Center;Cancer Control;Cancer Control Research;cancer health disparity;cancer prevention;Caring;Collaborations;Communities;community advisory board;community center;community collaboration;community engagement;community engagement process;Community Health;community partners;County;cultural competence;data management;data sharing;Development;early-career faculty;Economics;Elements;Equity;Ethnic Origin;experience;Faculty;Funding;Future;Geography;Goals;Health;health equity;health inequalities;Health Services Accessibility;Healthcare;Illinois;Individual;Inequity;innovation;interest;intersectionality;Intervention Trial;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;member;Methods;Missouri;Monitor;Multiple Myeloma;novel;Outcome;Outcomes Research;Phase;preference;Process;programs;Race;racial diversity;Recurrence;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Resources;response;Rural;Series;social determinants;social health determinants;structural determinants;Surveys;Testing;Time;Trust;Universities;Washington;Work

PROJECT_TITLE: Community Responsive Research Program


ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: NARRATIVE The Massachusetts Partnership for Community-Engaged Cancer Control Equity (Mass PCECCE) will focus on advancing cancer control equity by strengthening community health center's (CHC) capacity to deliver evidence-based cancer screening and tobacco treatment and by promoting social and digital connection among patients and their communities.

PI_NAMEs: CLARK, CHERYL RENEE;EMMONS, KAREN M. (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;Affect;Breast Cancer Detection;cancer care;Cancer Center;Cancer Control;Cancer Control Research;Cancer health equity;cancer prevention;Caring;Cervical Cancer Screening;Collection;colon cancer screening;colorectal cancer screening;Common Data Element;Communication;Communities;community academic partnership;community advisory board;community building;community clinical linkage;community engaged approach;community engagement;community intervention;community organizations;community partners;community partnership;Consultations;Data;Data Collection;data ecosystem;data management;design;Development;digital;Economics;effectiveness evaluation;Ensure;Equity;Evaluation;evidence base;Generations;Goals;Health;health care availability;health equity;health inequalities;implementation research;implementation science;improved;Inequity;innovation;interest;Intervention;Justice;Link;Malignant Neoplasms;Massachusetts;Measurement;Measures;Methodology;Methods;Modeling;Monitor;Neighborhood Health Center;Outcome;Pathway interactions;Patients;peace;Persons;Pilot Projects;Process;programs;Public Health Schools;Randomized;Recording of previous events;Research;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;screening;Screening for cancer;skills;social;social capital;System;Technology;Tobacco;tobacco cessation intervention;Tobacco Use Cessation;Training;Work

PROJECT_TITLE: The Mass Partnership for Community-Engaged Cancer Control Equity


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: EMMONS, KAREN M. (contact)

PROJECT_TERMS: Address;Affect;Articulation;Budgets;Cancer Control;cancer prevention;Collaborations;collaborative approach;Communities;community academic partnership;community engaged approach;community engaged research;community engagement process;Community Health;community organizations;community partners;community partnership;data management;design;Ecosystem;Ensure;Equity;Ethics;Evaluation;evidence base;Foundations;Goals;graduate student;Health;health care service;health inequalities;improved;Inequity;innovation;interdisciplinary collaboration;Intervention;Intervention Studies;Leadership;Learning;Massachusetts;Measures;member;Monitor;Outcome;Pathway Analysis;Play;Process;Productivity;programs;Public Health;Research;Research Methodology;Resource Sharing;Resources;Role;Science;social capital;social health determinants;Social Network;Structure;System;Training;Vision;Voice;Work

PROJECT_TITLE: Admin-Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health

PI_NAMEs: HANEUSE, SEBASTIEN  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Cancer Control;Clinical;Collaborations;Collection;Common Data Element;Communities;community advisory board;community center;community engagement;community engagement process;Community Participation;community partners;community partnership;Consultations;Data;Data Analyses;Data Collection;data de-identification;data ecosystem;data integration;data management;Data Reporting;data resource;data sharing;design;digital;Equity;Evaluation;evidence base;Goals;health equity;Health equity research;Individual;Infrastructure;Learning;Massachusetts;Measures;Methodology;Methods;multiple data sources;Neighborhood Health Center;Outcome;Patients;Performance;Policies;Positioning Attribute;Process;Productivity;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Screening for cancer;skills;social;social health determinants;social stigma;Standardization;Surveys;Tobacco;tool;Work

PROJECT_TITLE: Research Measures Method and Data Management Core


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cervical Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: LEE, REBEKKA MAIRGHREAD (contact)

PROJECT_TERMS: Adoption;Advanced Malignant Neoplasm;Affect;American;Breast Cancer Detection;Cancer Control;cancer prevention;Capital;Caring;Cervical Cancer Screening;Cities;Collaborations;colorectal cancer screening;Communities;community building;community collaboration;community engagement;community intervention;community partners;community partnership;design;digital;Dreams;Employment;Ensure;Equity;Ethnic Origin;evidence base;experience;Face;Gender;Geographic Locations;health care delivery;health economics;health equity;health inequalities;Health Insurance;Health system;Healthcare Systems;Home;improved;Incidence;Income;Industrialization;Inequality;Inequity;Infrastructure;innovation;Institution;Intervention;Investments;Language;Laws;Link;Local Government;Low income;Malignant Neoplasms;marginalized population;Massachusetts;Measures;Mediating;Methods;Minor;Neighborhood Health Center;neoplasm resource;Occupations;Outcome;Pathway interactions;Patients;point of care;Policies;Population;Race;Randomized;Research Design;Research Personnel;Research Project Grants;Resolution;Resources;Sales;scale up;screening;Screening for cancer;Site;skills;Smoking;social;social capital;social determinants;social health determinants;socioeconomics;Source;structural determinants;Structural Racism;Structure;successful intervention;System;Technology;therapy design;Tobacco;tobacco products;Tobacco use;Tobacco Use Cessation;tool;Voice;Wages


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Social Determinants of Health

PROJECT_TERMS: Academic support;Address;Breast Cancer Detection;Cancer Center;Cancer Control;Cancer Control Research;cancer prevention;Caring;Cervical Cancer Screening;Collaborations;colon cancer screening;Communities;community academic partnership;community advisory board;community building;community center;community clinical linkage;community engagement;community intervention;Community Outreach;Community Participation;community partners;community partnership;data management;Decision Making;design;digital;Ensure;Equity;evidence base;Funding;Goals;Governing Board;health equity;Health equity research;health inequalities;improved;Inequity;Intervention;Lived experience;Massachusetts;Measures;member;Neighborhood Health Center;Outcome;Pathway interactions;Patients;Preventive care;Process;programs;Research;Research Design;Research Methodology;Research Personnel;screening;Screening for cancer;Site;skills;social capital;social determinants;social health determinants;synergism;System;Testing;Textiles;tobacco cessation intervention;Voice;Work

PROJECT_TITLE: Community Responsive Project


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative: In this proposal, Baylor College of Medicine (BCM) and the University of Houston (UH) are coming together to form the Consortium for Translational and Precision Health. Our goal is to build on the strengths of BCM in basic and genomic science with the strengths of UH in the science of spreading information, entrepreneurship, pharmaceutical science, and community engagement. We will form a highly impactful organization that promotes the development of new ways to work on local and national health needs and reduces the time it takes for research discoveries to reach the doctor’s office, so it can help the right person at the right time.

PI_NAMEs: BEECH, BETTINA M.;KANWAL, FASIHA  (contact)

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: Acceleration;Address;Adopted;Affect;American;Area;authority;Basic Science;Behavior;Biomedical Research;career;career development;Catalogs;Clinical;clinical care;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;college;Communities;community engaged research;community engagement;Community Health Aides;Community Participation;community partners;Competence;Country;Data;data access;data integration;Data Sources;data tools;Decentralization;Development;digital;Disparity;disparity reduction;dissemination science;effective intervention;Effectiveness;Ensure;Entrepreneurship;Environment;Environmental Risk Factor;Equity;experience;Fostering;Funding;genome sciences;Genomics;Goals;Health;health disparity;health equity;Health Resources;Healthcare Systems;Home;improved;Infrastructure;innovation;Institution;Institutional Review Boards;inter-institutional;Intervention;Investments;Joints;Knowledge;Leadership;life span;Location;Medicine;Mentored Clinical Scientist Development Program;Methods;metropolitan;Mission;Modeling;Monitor;monitoring device;multidisciplinary;new technology;next generation;novel;Outcome;outreach;Participant;patient population;Patients;Persons;Pharmacologic Substance;Pharmacology;Phenotype;Population;population health;Population Heterogeneity;Precision Health;preservation;prevent;Process;Program Development;programs;Public Health Informatics;Recording of previous events;Research;research data dissemination;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Support;Resource Sharing;Resources;Science;screening;Services;smart device;social factors;Special Population;Structure;synergism;System;Texas;Time;tool;Training;translational pipeline;Translational Research;translational scientist;Translations;Underserved Population;Universities;Work;Workforce Development


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative Musculoskeletal health conditions lead to disuse, bone and muscle loss, and increased risk of bone fractures. Racial minorities have worse health outcomes during the recovery from musculoskeletal health conditions, suggesting specialized care is needed for genetically diverse patients. We will use the Diversity Outbred mouse population, an innovative animal model that incorporates the same genetic diversity found in humans, to perform a comprehensive analysis of how genetics and disuse influence the musculoskeletal system.

PI_NAMEs: MOELLER, FREDERICK GERARD (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Address;Animal Model;Award;bone loss;career;career development;Caring;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Sciences;Collaborations;Communities;community engaged research;community engagement;Data;data interoperability;Development Plans;Endowment;Fracture;genetic analysis;Genetic Variation;Goals;Health;health difference;health equity;Historically Black Colleges and Universities;Housing;Human;improved;Informatics;Infrastructure;innovation;Institution;Intervention;Lead;Low income;Machine Learning;medical schools;Mentors;Methods;Mus;Muscular Atrophy;Musculoskeletal;musculoskeletal injury;Musculoskeletal System;National Center for Advancing Translational Sciences;North Carolina;novel;Outcome;parent project;patient population;Patients;poor health outcome;Population;Population Heterogeneity;Pre-Clinical Model;prevent;Process;programs;Protocols documentation;racial minority;Recovery;recruit;Research;Research Personnel;Risk;Rural;rural patients;Techniques;telehealth;timeline;tool;Training;Training Programs;Translating;Translational Research;Underrepresented Minority;Universities;Virginia;Work;Workforce Development

PROJECT_TITLE: Wright Regional Center for Clinical and Translational Science


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hematology;Liver Disease

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Portal hypertension is a common final pathway of chronic liver disease and is responsible for significant morbidity and mortality among patients with liver disease. The goal of this research is to elucidate the role of neutrophil-platelet interactions in driving microvascular thrombosis which we previously identified as critical in the pathogenesis of portal hypertension. This proposal is expected to identify clinically-relevant mechanisms to inhibit the neutrophil-platelet interactions which drive portal hypertension.

PI_NAMEs: HILSCHER, MOIRA B (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adhesions;Attenuated;Automobile Driving;Binding;Biological;Blood Platelets;Blood Vessels;Calcium Signaling;Cells;chemokine;Chemotactic Factors;Chemotaxis;chronic liver disease;clinically relevant;Complex;congenital heart abnormality;Congestive;CXCL1 gene;Cytoplasmic Granules;Data;Development;Discontinuous Capillary;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;extracellular;extracellular vesicles;Fluorescence Microscopy;Functional disorder;Generations;Genetic;Goals;Hemostatic Agents;In Vitro;in vivo;in vivo Model;Inferior vena cava structure;Inflammatory;innovation;Integrins;Investigation;ITGAM gene;ITGB2 gene;Knock-out;Liver;Liver diseases;Liver Dysfunction;liver transplantation;mechanical force;Methods;Microfluidic Analytical Techniques;Microfluidics;Modeling;Morbidity - disease rate;mortality;mouse model;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;Organelles;Paracrine Communication;Pathogenesis;Pathway interactions;Patients;Periodicity;pharmacologic;Piezo 1 ion channel;Piezo ion channels;Platelet Glycoproteins;Portal Hypertension;Portal Pressure;prevent;Proteins;receptor;recruit;Regulation;Research;Role;Signal Pathway;Signal Transduction;Stretching;Testing;Therapeutic;therapy design;Thrombosis;Weibel-Palade Bodies

PROJECT_TITLE: Regulation of portal hypertension through neutrophil-platelet interactions in liver sinusoids

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Lupus;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: Gaithersburg

ORG_NAME: CARTESIAN THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE Cell therapy is a new technology that involves collecting a patient’s own immune cells, engineering them to fight a specific disease, then re-injecting the cells to the patient. In a recent clinical trial, we tested a new RNA-based approach for cell therapy that helped patients with the autoimmune disease myasthenia gravis. In this proposal will test if this exciting technology can also be used to safely and effectively treat patients with a different autoimmune disease, lupus.

PI_NAMEs: JEWELL, CHRISTOPHER M (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Admission activity;Advanced Malignant Neoplasm;Adverse event;Agreement;Ambulatory Care Facilities;Antibodies;antigen binding;Antigens;Arthralgia;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Binding;Blood;Body Weight;CAR antigen;CAR T cell therapy;Cell division;Cell Maturation;Cell secretion;Cell Therapy;Cells;cellular engineering;Characteristics;chemotherapy;chimeric antigen receptor T cells;Clinical;Clinical Data;clinical efficacy;Clinical Protocols;Clinical Research;Clinical Trials;Complement;cost;cytokine;cytokine release syndrome;Data;Data Management Resources;design;Disease;DNA;Dose;Drug Kinetics;ds-DNA;Elements;Eligibility Determination;Engineering;Enrollment;fighting;Genome;Goals;Great Britain;high risk;Hospitals;Hypersensitivity;Immune;immune function;Immunoglobulins;Immunology;Immunophenotyping;Impairment;improved;indexing;Inflammation;Inflammatory;Infusion procedures;Inpatients;Intensive Care;Letters;Lupus;Lymphocyte;Malignant Neoplasms;Measures;meetings;Messenger RNA;Monitor;Myasthenia Gravis;National Institute of Allergy and Infectious Disease;Neurology;Neuromuscular Junction;Neurotoxicity Syndromes;new technology;novel strategies;Nuclear;Nuclear Antigens;open label;Organ;pathogenic autoantibodies;Pathogenicity;Patients;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Placebo Control;Placebos;Plasma Cells;preconditioning;prevent;primary endpoint;Procedures;Production;Proliferating;Protocols documentation;Quality of life;Randomized;randomized placebo controlled trial;refractory cancer;response;RNA;Safety;safety assessment;Schedule;secondary endpoint;Serious Adverse Event;Serum;side effect;Site Visit;Small Business Innovation Research Grant;Source;Specific qualifier value;Systemic Lupus Erythematosus;T-Lymphocyte;Technology;Testing;Therapeutic;Toxic effect;Transfection;Transplantation;trial design;Vaccines;Work

PROJECT_TITLE: Targeting BCMA+ Cells with RNA-engineered CAR T cells to treat Lupus: A Phase 2 clinical study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 PT-I (M2)]


ORG_DEPT: FAMILY MEDICINE

PHR: OVERALL: PROJECT NARRATIVE The Virginia Advancing Cancer Control Equity Research Through Transformative Solutions (VA-ACCERT) Center fortifies a community-academic partnership between the Virginia Commonwealth University, the Eastern Virginia Medical School, and Virginia’s federally supported, income-based housing communities with the infrastructure to design and conduct multi-level, health promotion and cancer prevention interventions that address the complex social drivers of health that impede cancer health equity in these communities. The VA- ACCERT Center also strives to engage early-career investigators from groups underrepresented in behavioral and biomedical sciences to advance future cancer prevention research among income-based housing populations. Ultimately, the Center will disseminate and promote the adoption of its findings and best practices so they can be adapted to similar income-based housing communities across the United States.

PI_NAMEs: FUEMMELER, BERNARD F (contact);LAROSE, JESSICA GOKEE;SHEEHAN, BRYNN

PROJECT_TERMS: active lifestyle;Address;Adoption;Advanced Malignant Neoplasm;authority;Behavioral;Cancer Burden;Cancer Control;Cancer Control Research;Cancer health equity;cancer prevention;Cancer Prevention Intervention;cancer risk;career;Collaborations;Communication;Communities;community academic partnership;community advisory board;community building;community empowerment;community engagement;community partnership;Complex;Country;data management;data sharing;design;Development;Dietary Practices;digital;Dissemination and Implementation;Diverse Workforce;Education;Elements;Equity;Ethics;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;experience;Family;Fortification;Funding;Future;Goals;Health;health equity;health equity promotion;Health equity research;health information technology;Health Promotion;Health Sciences;Healthy Eating;Housing;implementation intervention;implementation outcomes;implementation process;improved;Income;Individual;Inequity;Infrastructure;Insurance;Lead;Leadership;Malignant Neoplasms;marginalization;marginalized population;Measures;Medical;medical schools;member;Methods;Modeling;moderate-to-vigorous physical activity;National Cancer Institute;Neighborhoods;Outcome;outreach;Participant;peer;Persons;Policies;Population;prevention practice;Prevention Research;prevention service;preventive intervention;Preventive service;Principal Investigator;public health insurance;Public Housing;Race;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk Reduction;Schools;Science;Screening for cancer;Section 8;sedentary lifestyle;service delivery;service uptake;Services;Shapes;skills;social;social capital;social cognitive theory;social interventions;System;Testing;Theoretical model;Training;U.S. Department of Housing and Urban Development;Underrepresented Populations;United States;Universities;Virginia;Work