NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Prevention

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE The proposed research addresses the pressing public health concern of microplastics exposure, particularly its impact on colorectal cancer, a disease with significant health implications and limited treatment options. By investigating the effects of microplastics exposure on human colons across the lifespan, this research aims to provide crucial insights that can inform preventive and therapeutic strategies, aligning with the NIH's goal of advancing research for disease prevention and treatment. Overall, this study holds promise for developing innovative approaches to mitigate the adverse effects of environmental microplastics on human health.

PI_NAMEs: SANCHEZ, YOLANDA  (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;Administrative Supplement;Adverse effects;Age;American Indians;Archives;Cadaver;Cancer Center Support Grant;Cancer Control;Cell Physiology;Cellular Structures;Characteristics;Chronic;Clinical;Colon;colon cancer patients;colon growth;Colonic Neoplasms;Colorectal;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;Colorectal Neoplasms;Communities;Comprehension;Consumption;Data;Development;Disease;disorder prevention;dysbiosis;Ecosystem;Elements;Environment;Epithelial Cells;exposed human population;Exposure to;Face;Food;Food Contamination;Functional disorder;Goals;Growth;gut inflammation;Health;high risk;Hispanic;Human;human tissue;improved;in vivo;Inflammation;Ingestion;Inhalation;innovation;insight;interest;Intestines;Investigation;Life Cycle Stages;life span;Link;Molecular;multiple omics;Mus;Neoplasm Metastasis;New Mexico;Organ;Oxidative Stress;particle;Patients;Persons;Plastics;pollutant;Pollution;Polyethylenes;Polystyrenes;Population;Pre-Clinical Model;prevent;Preventive;Production;Public Health;Quality of life;Reporting;Research;response;Risk;Sampling;Skin;STEM research;Survival Rate;Therapeutic;three dimensional cell culture;Time;tissue culture;Tissues;Toxic effect;Toxicant exposure;trend;tumor;tumor growth;Tumor Tissue;United States National Institutes of Health;Universities;uptake;Validation;Water;Weight;Western Blotting

PROJECT_TITLE: The impact of microplastics exposure across lifespan on human colons


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Prevention

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Microplastics, tiny plastic particles that are a source of widespread environmental contamination, may contribute to adverse health conditions in humans, including colorectal cancer. In this project, we will measure the presence and level of microplastics in human stool and colorectal tumor tissue samples to compare the burden of microplastic contamination by colorectal cancer history and by age at colorectal cancer diagnosis. We will also assess how chemical additives that leach out of microplastics, impact different cancer pathways.

PI_NAMEs: LYNCH, THOMAS JAMES (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: absorption;Address;Administrative Supplement;Adult;Age;aged;Air;Anatomy;Apoptosis;Beverages;bioaccumulation;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer diagnosis;Carcinogens;Chemicals;cohort;Cohort Studies;colon cancer patients;colon carcinogenesis;Colonic Diseases;Colorectal Cancer;Colorectal Neoplasms;Development;DNA Damage;drinking water;early onset;Environment;Environmental Pollutants;Environmental Pollution;epidemiology study;experience;Exposure to;Feces;Food;Food Supply;gastrointestinal epithelium;Gene Expression;Generations;gut microbiome;Health;Human;Human body;human tissue;Immune response;In Vitro;Incidence;Incubated;Individual;Industrialization;Inflammatory Bowel Diseases;Inflammatory Response;Ingestion;Inhalation;Intestines;Knowledge;Large Intestine;Late-Onset Disorder;Life;Link;Literature;Lung;Malignant Neoplasms;Measurable;Measures;Metabolism;Methods;microbial;Mucous body substance;multi-ethnic;Nature;Oceans;Organoids;Participant;particle;pathogenic bacteria;Pathway interactions;Patients;Placenta;Plastics;Pollution;Polymers;Polyvinyl Chloride;Population;Pre-Clinical Model;Probability;Production;Proliferating;Raman Spectrum Analysis;Reactive Oxygen Species;Recording of previous events;Rectal Diseases;Reporting;Resources;response;Role;Sampling;Seminal fluid;sound;Source;System;Thinness;timeline;Tissue Sample;Tissues;Tumor Tissue;wasting;Water Supply;Work

PROJECT_TITLE: CCSG Administrative Supplement for Contemporary Modifiable Exposures and Cancer Across the Cancer Control Continuum


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WASHINGTON

ORG_NAME: DC DEPARTMENT OF HEALTH

ORG_STATE: DC

PHR: Attachment 1 Project Narrative Introduction th Regulation Licensing Administration (HRLA), Food Safety and Hygiene Inspection Services Division (FSHISD) seeks funding of $25,000 from the United States Food and Drug Administration, as part of the Food Protection Task Force (FPTF) and Integrated Project Grant Program (R19)

PI_NAMEs: MOORE, JOYCE A (contact)

PROGRAM_OFFICER_NAME: HEAD, DANIELLE

PROJECT_TITLE: The Annual Food Safety and Defense Conference, held in the District of Columbia, is an educational conference and collaborative effort with stakeholders in the District.

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (06)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE Pain is a common and disabling problem for many people and there is a desperate need to develop non- addictive, safe and effective treatments as quickly as possible. The Early Phase Pain Investigation Clinical Network (EPPIC-Net) is being developed so that when new, potentially promising treatments are discovered they can be rapidly tested. This application proposes that the Icahn School of Medicine at Mount Sinai (ISMMS) and the Mount Sinai Health System, which are a major research institution and provider of healthcare in New York City, should be included as an EPPIC-Net site.

PI_NAMEs: ROBINSON-PAPP, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BARNES, JENNIFER HAMILTON

PROJECT_TERMS: addiction;African American population;Agreement;Anesthesiology;biomarker validation;Caring;Chronic low back pain;Clinical;clinical center;clinical investigation;clinical pain;clinical phenotype;clinical practice;Clinical Trials;Clinical Trials Design;Collaborations;Communities;Connecticut;Data Collection;data quality;design;Development;Disabling;Discipline of Nursing;Discipline of obstetrics;effective therapy;Emergency Medicine;Ensure;experience;Faculty;flexibility;Future;Gastroenterology;Geriatrics;Gynecology;Health Personnel;Health Sciences;Health system;Hematology;Hispanic Populations;Hospitals;improved;Infrastructure;innovation;Institution;Institutional Review Boards;Internal Medicine;Knowledge;Leadership;medical schools;medical specialties;Medicine;member;Minority Groups;Mission;Modeling;multidisciplinary;National Institute of Neurological Disorders and Stroke;Neurology;neurosurgery;New York City;Oncology;operation;Ophthalmology;Orthopedics;Pain;Pain Disorder;Pain management;Pain Research;Palliative Care;Participant;patient population;Patients;Pediatrics;Persons;Phase;Phase II Clinical Trials;Phenotype;Physical Medicine;Physical Rehabilitation;Placebo Effect;Podiatry;Population Heterogeneity;Positioning Attribute;protocol violation;Protocols documentation;Psychiatry;Psychology;recruit;Reporting;Research;Research Personnel;Rheumatology;Services;Site;Structure;success;Syndrome;Tennessee;Testing;Training;Underinsured;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;validation studies;Work

PROJECT_TITLE: The Icahn School of Medicine at Mount Sinai (ISMMS) EPPIC-Net Specialized Clinical Center


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: BALTIMORE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Post-surgical pain is a major clinical problem requiring new treatment strategies that do not rely on opioids. This project proposes to validate ASCT2 as an endogenous mechanism that aids in the resolution of postoperative pain. Moreover, innovative RNA-based strategy that enhances the translation of ASCT2 and alleviates postoperative pain will be validated.

PI_NAMEs: MELEMEDJIAN, OHANNES KEVORK (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: abuse liability;Acute Pain;Adopted;Affect;Afferent Neurons;Attenuated;Biochemical;Biochemical Process;Biological Assay;Catabolism;Cell Physiology;Cells;Chronic;chronic pain;chronic pain patient;chronic painful condition;Citric Acid Cycle;Clinical;Data;Dependence;Development;Event;experience;flexibility;fluorescence imaging;Genes;Genetic Polymorphism;Glutamine;Goals;healing;Health;imaging modality;immunogenicity;in vivo;Incidence;Injections;Injury;innovation;knock-down;Knowledge;Link;Measures;Mediating;Metabolic;Metabolism;Methods;Mitochondria;Modeling;Molecular;Molecular Target;molecular targeted therapies;Mus;Neurons;novel;novel therapeutic intervention;novel therapeutics;Nutrient availability;Operative Surgical Procedures;Opioid;overexpression;oxidation;Pain;pain chronification;Pathology;Patients;Persistent pain;Postoperative Pain;prevent;Process;Public Health;Pyruvate;Recovery;Research;Resolution;Risk;RNA;Role;Safety;sensor;side effect;Site;Supplementation;Surgical incisions;Therapeutic;therapy development;Translations;Trauma;treatment strategy;Validation;Viral

PROJECT_TITLE: Validating ASCT2 for the Treatment of Chronic Postsurgical Pain


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative The short-term goal of this K23 award is the development of the PI as an independent investigator skilled in the assessment and behavioral intervention, most especially focused on underrepresented and vulnerable aging populations, in rural regions who are disproportionately impacted by dementia. The proposed research will use a non-pharmacological, environmental approach to develop assessments and tailored interventions that can be delivered via telehealth to improve behaviors and activity engagement for people with dementia in their home. The long-term goal is to empower older adults with dementia to age in place within their home with minimal behavior disruption and maximum activity participation.

PI_NAMEs: RHODUS, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Active Learning;Address;Adoption;Adult;Advisory Committees;Aggressive behavior;Aging;aging in place;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Analysis of Covariance;Anxiety Disorders;arm;Behavior;Behavior assessment;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;Behavioral Model;behavioral response;Behavioral Symptoms;career;career development;Career Mobility;Caregiver Burden;caregiver education;caregiver quality of life;Caregivers;Caring;Client satisfaction;Clinic;Clinical;Clinical assessments;Clinical Trials Design;college;Communities;community based research;Country;Cues;Data;Death Rate;Dementia;dementia care;Development;Development Plans;Diagnosis;dimension reduction;empowerment;Environment;environmental intervention;evidence base;experience;Extramural Activities;Faculty;feasibility trial;Fellowship;follow-up;Fostering;Foundations;Funding;Future;Goals;Grant;health disparity;health equity;Health equity research;Health Services Accessibility;Home;Home environment;improved;in-home care;Individual;innovation;Institution;Institutionalization;Intervention;Interview;Kentucky;knowledge base;Letters;Measurement;Measures;Medicine;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Morbidity - disease rate;mortality;Neurology;Neurosciences;Nonpharmacologic Therapy;novel strategies;older adult;Pamphlets;patient home care;Performance;Persons;Physiological;Population;Positioning Attribute;Postdoctoral Fellow;programs;Protocols documentation;Proxy;psychiatric symptom;Psychiatrist;Psychophysiology;Quality of life;Randomized, Controlled Trials;Reporting;Research;Research Activity;research and development;Research Personnel;Residencies;response;Rural;Rural Appalachia;rural area;Rural Community;Safety;satisfaction;Scholarship;Science;Scientist;Single-Blind Study;skills;Sleep Disorders;social;standard of care;Stimulus;supportive environment;Surveys;Teacher Professional Development;telehealth;tenure track;Testing;therapy development;tool;Training;Underrepresented Populations;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Improving Person-Environment Fit of Community-Residing Older Adults with Dementia Through Assessment and Individualized Intervention

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study will examine midlife women's relationships and support exchanges with their late adolescent and adult children, as well as with other kin and non-kin, and the implications of these relationships and exchanges for women's psychosocial well-being. The experienced bi-national team will collect and analyze survey and in-depth interview data building upon an existing longitudinal panel of women in rural Mozambique, a setting that in many respects is typical of sub-Saharan Africa. The results of this study will fill important gaps in our understanding of intergenerational and community relationship dynamics and their consequences for women's welfare in rapidly changing resource-limited patriarchal contexts and will inform policies aimed at improving health and well-being of rural women and at optimizing health and social services for that vulnerable population segment.

PI_NAMEs: AGADJANIAN, VICTOR  (contact);HAYFORD, SARAH R

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adolescent;Adult Children;Affect;Africa South of the Sahara;Aging;Anxiety;Characteristics;Child;child bearing;Child Rearing;Collaborations;Collection;Communities;Community Surveys;Coping Skills;Data;Data Collection;Databases;Decision Making;Economic Conditions;Economics;Education;Emotional;Employment;experience;Exposure to;Family;Gender;Generations;Happiness;Health;Health Services;Household;human old age (65+);Husband;improved;Income;interest;intergenerational;Interview;Investments;labor force participation;Labor Migrations;Laws;Life;Link;Low income;Marriage;Measures;member;men;Mental Depression;Mental Health;middle age;Midlife women;migration;Mozambique;multidisciplinary;Nutritional;Outcome;Parent-Child Relations;Parents;Participant;Pattern;Personal Satisfaction;physical conditioning;Physical shape;Policies;Process;Productivity;psychosocial outcome;psychosocial wellbeing;Recording of previous events;Reproduction;reproductive;Research;residence;Residential Mobility;Resources;Rural;Rural Community;rural families;rural setting;safety net;satisfaction;Scholarship;Security;Self Efficacy;Shapes;Site;skills;social;Social Change;Social Functioning;Social Interaction;social relationships;Social support;Social Work;socioeconomics;Standardization;stressor;Structure;Surveys;Time;transition to adulthood;Uncertainty;Variant;Vulnerable Populations;welfare;Woman;Women's Health

PROJECT_TITLE: Women’s Social Ties and Psychosocial Well-Being in a Resource-Limited Patriarchal Setting: A Longitudinal Perspective

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Family health history (FHH), a critical component of genomic medicine that is essential for both identifying individuals at risk for hereditary conditions and for contextualizing results of genetic testing, continues to be broadly underutilized and underappreciated in clinical care. Barriers to adequate data collection and synthesis are numerous and cross all clinical stakeholders: patients, providers, and health systems. Significantly, they include the pervasive view that FHH is unimportant except in select cases and that it rarely contributes to clinical decision making. With this perspective, few providers have been willing to allocate precious time to collect detailed FHHs or to learn the complex algorithms required to synthesize FHH data into actionable care plans. However, in studies of systematic FHH-based risk assessments in unselected populations, 25% of patients meet risk criteria for (actionable) hereditary conditions. FHH-based risk assessment programs have emerged to address these barriers, but as designed do not meet the needs of low literacy, low resource populations. The goal of this proposal is to develop a scalable end-to-end solution for risk assessment and management that meets the needs of low resource settings. Our central hypothesis is that combining FHH- driven risk assessment, a literacy-enhanced interface using voice-to-text response capture (like ‘Siri’), family engagement (through social networking platforms for data gather and risk sharing), and a genetic testing delivery system, will create a solution that engages and increases the proportion of diverse patients who are identified as at increased risk, who undergo testing, and, when appropriate, who initiate cascade screening among relatives. In this proposal we will define and deploy this new care delivery model as the “Genomic medicine Risk Assessment Care for Everyone” (GRACE). To this end we will 1) develop and deploy the model using pre-implementation assessments at clinical sites with highly diverse patient populations to select the most appropriate integration options and pathways for both patients and providers; and 2) perform a randomized implementation-effectiveness pragmatic hybrid trial to assess implementation and effectiveness outcomes relevant to these diverse populations. Outcomes will include reach, uptake, clinical utility, accessibility, genetic testing frequency, genetic testing results, and cost-effectiveness. In addition we will convene an advisory panel of stakeholders from industry (laboratories, insurers), providers, patients, and health system to understand sustainability and address knowledge gaps that will promote access when the trial is over.

PI_NAMEs: ORLANDO, LORI ANN (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Address;Adoption;Agreement;Algorithms;Beds;Caring;cascade genetic testing;Clinical;clinical care;clinical decision-making;clinical research site;cohort;Complex;cost;cost effectiveness;Counseling;COVID-19 pandemic;Data;Data Collection;data platform;design;Development;effectiveness outcome;effectiveness/implementation trial;Enrollment;evidence base;Family;Family health status;Family member;Frequencies;genetic testing;Genomic medicine;Goals;Guidelines;health disparity;Health system;hereditary risk;Hybrids;implementation evaluation;implementation framework;implementation outcomes;implementation science;implementation/effectiveness;improved;Individual;Industry;Inherited;Insurance Carriers;Intervention;Knowledge;Laboratories;Learning;Length;literacy;Measures;Modeling;multi-ethnic;National Human Genome Research Institute;Outcome;Paper;Pathway interactions;patient population;Patients;Population;Population Heterogeneity;power analysis;pragmatic implementation;Primary Care;Process;programs;Protocols documentation;Provider;Randomized;Recording of previous events;recruit;Resource-limited setting;Resources;response;Risk;Risk Assessment;Risk Management;risk sharing;secondary analysis;Service delivery model;Site;Social Network;System;Test Result;Testing;Text;Time;uptake;Voice

PROJECT_TITLE: IGNITE Cost Extension- Year 7


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative In all life forms on earth, DNA carries the hereditary genetic information. Transcription copies DNA into RNA, a key process that permits gene expression. On occasion, the nascent RNA can become entangled with the DNA, resulting in an alternative three-stranded nucleic acid structure called an R-loop. R-loops form universally under normal conditions and are thought to play physiological roles in cells, including human cells. Studies have suggested, however, that under conditions where transcription is perturbed, harmful R-loops are created, leading to DNA breaks and chromosome anomalies. What distinguishes “good” from “harmful” R-loops remains unknown. Similarly, how harmful R-loops arise as a result of perturbed transcription is unclear. Using innovative technologies developed by my group, we will characterize the formation of so-called harmful R- loops under conditions of perturbed transcription in human cells. We will also determine whether harmful R- loops, or perturbed transcription itself, are the cause of the DNA breaks. Finally, we will determine if an enzyme known to relieve the DNA break problem is acting by resolving harmful R-loops or remediating the altered transcription. This work will benefit our understanding of fundamental cellular processes acting in our genome and will provide insights into a range of human disorders linked to perturbed transcription.

PI_NAMEs: CHEDIN, FREDERIC LOUIS (contact)

PROGRAM_OFFICER_NAME: KRASNEWICH, DONNA M

PROJECT_TERMS: Address;Attention;Biochemical;Biogenesis;Cell model;Cell Physiology;Cells;Chromosome abnormality;Data;Defect;Disease;DNA;DNA Damage;DNA Structure;DNA-Directed RNA Polymerase;Enzymes;Functional disorder;Gene Expression;genetic information;Genetic Transcription;Genome;Genomic Instability;Genomics;Human;Inherited;innovative technologies;insight;Knowledge;Life;Light;Link;Maintenance;Mammalian Cell;Mammals;Measures;Metabolism;Monitor;Nuclear;nucleic acid structure;overexpression;Pathway interactions;Pattern;Phenotype;Physiological;Planet Earth;Play;Process;remediation;Resolution;ribonuclease H1;RNA;RNA Processing;RNA Splicing;Role;Structure;Time;Work;Yeasts

PROJECT_TITLE: Understanding the mechanisms underlying R-loop biogenesis and resolution in mammals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The membrane-interacting domains of class I viral fusion proteins, such as HIV-1 Env, appear to play much greater roles in its stability, function and antigenicity than what has been appreciated previously. This proposal aims to determine atomic structures of these domains in a physiologically relevant environment, to assess their functional roles in viral infection and to facilitate development of intervention strategies.

PI_NAMEs: CHEN, BING  (contact);HARRISON, STEPHEN COPLAN

PROGRAM_OFFICER_NAME: CHAKRABARTI, BIMAL KUMAR

PROJECT_TERMS: Adopted;Biological Assay;Chimeric Proteins;Coupled;Cryoelectron Microscopy;Cytoplasmic Tail;Elements;env Gene Products;Environment;fascinate;HIV;HIV-1;Intervention;Length;Lipid Bilayers;Lipids;Membrane;Membrane Fusion;Molecular Conformation;Mutagenesis;nanodisk;Peptides;Physiological;Play;Process;protein folding;protein reconstitution;Proteins;Role;SARS-CoV-2 spike protein;SIV;Structure;Technology;therapeutic target;therapy development;Vaccines;Viral Fusion Proteins;Virus Diseases

PROJECT_TITLE: Structure-function studies of the membrane-interacting domains of HIV-1 Env spike

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Cost Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Maternal Health;Maternal Morbidity and Mortality;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Women's Health Research

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE As opioid use disorder (OUD) and hepatitis C virus (HCV) infection prevalence continue to rise in the United States, particularly among young women, new strategies are needed to identify high-impact venues to address both epidemics together. Pregnancy is a motivating time for women to engage in care for both their own health and that of their families. This project will utilize programmatic and public health data and simulation modeling to project the clinical and cost-effectiveness of employing interventions in the perinatal care venue to reduce opioid-related mortality and HCV transmission.

PI_NAMEs: EPSTEIN, RACHEL LEE (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Adult;Age;Age Reporting;Award;Calibration;care costs;care delivery;care seeking;career;career development;Caring;Child;Childhood;Clinic;Clinical;clinical effect;Clinical effectiveness;Communicable Diseases;comparative cost effectiveness;cost;Cost Analysis;cost effective;cost effectiveness;Cost effectiveness research;Data;Death Rate;Decision Modeling;design;Diagnosis;Discipline of obstetrics;disease transmission;economic evaluation;efficacy evaluation;Epidemic;epidemic virus;experience;Family;Future;Goals;Health;health care service utilization;health data;health economics;health service use;Healthcare;Hepatitis C;Hepatitis C Incidence;Hepatitis C Therapy;Hepatitis C Transmission;Hepatitis C virus;HIV;Hospitalization;Human;improved;Infant;Infection;injection drug use;innovation;Inpatients;Intervention;K-Series Research Career Programs;Learning;Link;Maternal Mortality;Measures;medication for opioid use disorder;Medicine;Mentors;Methods;microcosting;Modeling;models and simulation;mortality;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid misuse;opioid mortality;opioid overdose;opioid use disorder;Outcome;Overdose;overdose death;Overdose reduction;Perinatal;Perinatal Care;perinatal health;perinatal period;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;Population Decreases;post pregnancy;Postpartum Period;Predisposition;Pregnancy;pregnancy related death;Pregnant Women;prenatal;Prevalence;prevent;programs;Public Health;Publishing;Quality-Adjusted Life Years;Recovery;reproductive;Research;Research Personnel;Resource Allocation;Resources;retention rate;Risk Factors;Role;Sampling;Science;Seroprevalences;Services;skills;substance use;Techniques;Testing;Time;Training;transmission process;United States;United States National Institutes of Health;virus testing;Visit;Woman;Women's mortality;Work;young woman;Youth

PROJECT_TITLE: Perinatal care as a venue to reduce opioid overdoses and hepatitis C virus incidence (PreVenT OD HCV)

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative: Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Unfortunately, patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD. The existing resources of the NIAAA-funded AlcHepNet are used for patient studies, biospecimen collection and site-specific translational studies.

PI_NAMEs: DASARATHY, SRINIVASAN  (contact);STREEM, DAVID

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinic;Clinical;clinical center;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collection;Combined Modality Therapy;Compensation;Computers;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hospitals;improved;Individual;Informatics;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resource Allocation;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;translational study;Transplantation;treatment strategy;Zinc

PROJECT_TITLE: Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD)- Cleveland Clinic Clinical Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (05)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Back Pain;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pain Research;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Chronic low back pain (cLBP) affects over 10% of adults in the US, contributing to the burden of disability and health care costs, and putting those suffering from cLBP at risk of opioid addiction or even overdose. The National Institutes of Health is funding a patient-centric research program to discover new low back pain mechanisms and develop improved diagnostic and treatment algorithms through extensive patient phenotyping and use of precision medicine approaches. Our proposal is to provide network leadership and operations support, state-of-the-art data integration and analytics infrastructure, and bioinformatics and statistical expertise to support the research goals of the BACPAC.

PI_NAMEs: ANSTROM, KEVIN J (contact);IVANOVA, ANASTASIA ;MAUCK, MATTHEW CHRISTOPHER

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Adoption;Adult;Affect;algorithm development;Algorithms;Back Pain;Bioinformatics;Biological;Biological Markers;biomarker signature;Chronic;Chronic low back pain;clinical application;Clinical Medicine;clinical pain;Clinical Treatment;Clinical Trials;cohesion;Collaborations;collaborative trial;Communication;computerized data processing;Conduct Clinical Trials;Consensus;Data;Data Analyses;Data Analytics;data cleaning;data ecosystem;data integration;data management;data portal;Data Set;data sharing;data sharing networks;Data Storage and Retrieval;design;Development;Diagnostic;disability burden;Disease;Elements;Enrollment;Ensure;Evaluation;experience;Foundations;Funding;Gills;Goals;Health Care Costs;Helping to End Addiction Long-term;improved;individual patient;Infrastructure;innovation;Intervention;Investigation;Knowledge;Lead;Leadership;Learning;Low Back Pain;Machine Learning;Manuscripts;meetings;Methodology;Methods;Modeling;Monitor;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;neural network;North Carolina;novel;Online Systems;operation;Operations Research;Opiate Addiction;organizational structure;Outcome;Overdose;Pain Research;Participant;patient oriented;patient population;patient stratification;Patients;Performance;personalized intervention;personalized medicine;Phase;Phase II Clinical Trials;Phenotype;phenotypic data;precision medicine;prediction algorithm;Prediction of Response to Therapy;Preparation;Principal Investigator;Privatization;Productivity;programs;Public Health;Publications;Quality Control;Reporting;repository;Reproducibility;Research;Research Personnel;Research Support;Resources;Risk;risk mitigation;Schools;Secure;Site;social media;Solid;sound;Statistical Data Interpretation;Strategic Planning;Structure;success;Surveys;Systems Integration;Technology;Technology Assessment;Therapeutic Intervention;timeline;tool;translational medicine;treatment trial;trial design;United States National Institutes of Health;Universities;user-friendly;Vertebral column;Vision;web site;Work;Writing

PROJECT_TITLE: Back Pain Consortium (BACPAC) Research Program Data Integration, Algorithm Development and Operations Management Center


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Psoriasis, a prevalent chronic inflammatory skin disease, is associated with an increased risk of type 2 diabetes (T2D); however, the molecular mechanisms that predispose patients with psoriasis to develop T2D are unknown. We have identified that keratinocyte overexpression of interferon kappa (IFNκ), a type I IFN upregulated in psoriatic skin, is associated with impaired metabolic function and promotes increased inflammatory macrophages (MΦs) in skin and adipose tissue. This proposal will seek to elucidate how overexpression of IFNκ in psoriatic keratinocytes is regulated and how increased IFNκ produced by keratinocytes drives increased inflammatory MΦs in the skin and adipose tissue that leads to impaired adipocyte-mediated glycemic control.

PI_NAMEs: WOLF-FORTUNE, SONYA J (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Adipocytes;Adipose tissue;Anti-Inflammatory Agents;Automobile Driving;Award;Cardiovascular system;Cells;Chronic;chronic inflammatory skin;cost;cytokine;Data;Development;Diabetes Mellitus;Disease;Enzymes;Epigenetic Process;experimental study;Faculty;Functional disorder;Gene Expression;Genetic;Genetic Models;glucose metabolism;GLUT 4 protein;glycemic control;Healthcare Systems;histone demethylase;histone methyltransferase;Homeostasis;Human;Hyperglycemia;Imiquimod;Impairment;improved;Inflammation;Inflammatory;Interferon Type I;Interferons;JAK1 gene;keratinocyte;Laboratories;Lead;Link;Literature;Macrophage;Mediating;Metabolic;Metabolic dysfunction;Methods;MLL gene;Molecular;Morbidity - disease rate;mortality;Mus;Myeloid Cells;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;overexpression;Patients;peripheral blood;pharmacologic;Phase;Phenotype;PPAR gamma;Process;Production;programs;Psoriasis;Publishing;Regulation;Research;Research Personnel;Research Training;Risk;Risk Factors;Role;Running;Sequence Analysis;Signal Transduction;skills;Skin;skin disorder;skin lesion;Skin Tissue;STAT1 gene;STAT3 gene;systemic inflammatory response;targeted treatment;Techniques;Testing;Time;Tissue Sample;Tissues;TNF gene;Training

PROJECT_TITLE: Role of IFN kappa in psoriasis-mediated diabetes development

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Unfortunately, patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD. The existing resources of the NIAAA-funded consortium are used for patient studies, biospecimen collection and site-specific translational studies.

PI_NAMEs: KARPYAK, VICTOR M.;SHAH, VIJAY H. (contact)

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinic;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collection;Combined Modality Therapy;Compensation;Computers;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hospitals;improved;Individual;Informatics;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resource Allocation;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;translational study;Transplantation;treatment strategy;Zinc

PROJECT_TITLE: Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) – Mayo Clinic


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE Alternative approaches to inhibit/suppress/cure HIV-1 infection are needed. The proposed collaborative research program will provide structural details about HIV-1 protein and nucleic acid interactions, with the expectation that strategies for developing improved or new HIV-1 inhibitors will emerge.

PI_NAMEs: GRONENBORN, ANGELA M. (contact);POLENOVA, TATYANA

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Area;Capsid;career development;Chromatin;Chronic Disease;Collaborations;Communication;comorbidity;Complex;Cryoelectron Microscopy;design;Development;Drug resistance;Ensure;expectation;fundamental research;HIV;HIV-1;HIV/AIDS;improved;In Situ;Infection;inhibitor;Integrase Inhibitors;Knowledge;Mentors;Mission;NMR Spectroscopy;Nuclear;Nucleic Acids;Positioning Attribute;Productivity;Program Development;programs;protein complex;Proteins;Research;Research Personnel;Resistance development;Resolution;RNA;single molecule;Structure;tool;trafficking;Variant;virology;Work

PROJECT_TITLE: Pittsburgh Center for HIV Protein Interactions (PCHPI)


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: REMGSAMAI-NHE, CARINA  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;Asia;Caribbean region;Clinical Research;clinical research site;Cognitive;comorbidity;Contracts;Country;Databases;design;Equipment and supply inventories;Europe;expiration;Good Manufacturing Process;HIV/AIDS;International;Label;manufacturing facility;Monitor;National Institute of Allergy and Infectious Disease;operation;Pharmaceutical Services;Pharmacists;Pharmacy facility;Process;Protocols documentation;Qualifying;Regulation;Reporting;Research;Shipping;Site;South America;Technical Expertise;United States;Validation;Work

PROJECT_TITLE: Clinical Research Products Management Center (CRPMC)


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE: The swallowing muscles are prone to decreased strength and function as part of the natural aging process which can lead to difficulty swallowing, malnutrition, and frailty. Exercise and nutrition are powerful stimulators of muscular change. The proposed research will investigate the effectiveness of a proactive regimen of swallowing exercises (with or without daily protein supplement drinks) to improve the composition, force, and physiology of the swallowing muscles and explore the relationship to overall health and physical function in community-dwelling older adults.

PI_NAMEs: MOLFENTER, SONJA M (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Age;age related;age related decline;age-related muscle loss;Aging;aging process;Aspiration Pneumonia;Biochemical Markers;Biomechanics;Biometry;Blood specimen;Body Composition;care outcomes;Clinical;Communities;comorbidity;constriction;Consumption;Data;Deglutition;Deglutition Disorders;Dehydration;demographics;design;Dose;effective intervention;Effectiveness;Empirical Research;Exercise;exercise regimen;experience;Fatty acid glycerol esters;Food;Frail Elderly;frailty;Frequencies;Funding;Goals;Hand Strength;Health;healthy aging;Human;Image;Impairment;improved;Individual;Inferior;instrumentation;Intervention;Investigation;Limb structure;Liquid substance;Literature;Magnetic Resonance Imaging;Malnutrition;Manometry;Measures;Mechanics;Mental Depression;Methods;multidisciplinary;Muscle;muscle form;Muscle function;muscle physiology;muscle strength;Muscular Atrophy;normal aging;nursing skill;nutrition;Nutritional status;older adult;Outcome;Outcome Measure;Participant;Patients;Periodicity;Persons;Pharyngeal structure;pharynx muscle;Phase;Physical Function;Physical Performance;Physiological;Physiology;Pneumonia;Population;Positioning Attribute;Prealbumin;Prediction of Response to Therapy;prevent;Process;Proteins;Protocols documentation;Quality of life;Radiology Specialty;Randomized;Regimen;Research;Research Design;Resistance;Resolution;Risk;Role;sarcopenia;Science;sex;Social isolation;study population;success;Supplementation;Testing;United States National Institutes of Health

PROJECT_TITLE: Proactive pharyngeal swallowing exercises: Building muscular reserve in pre-frail older adults

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE OF FUNDED PARENT AWARD (1R01DC020229)  (NO CHANGE)  There are over 200,000 individuals with Down syndrome in the United States, and most rely on hearing to communicate. The proposed research is relevant to public health because it is focused on understanding how speech perception and auditory skills mature for infants, children, and young adults with Down syndrome. The results generated from this project are expected to provide new information about the factors that support communication outcomes for individuals with Down syndrome, and support the development of interventions to maximize listening, learning, and communication in noisy listening environments, such as classrooms.

PI_NAMEs: LEIBOLD, LORI J. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Achievement;Acoustics;adopted child;Adult;Attention;Audiology;Auditory;Behavior;Child;Childhood;clinical practice;Cognitive;Communication;Communications Media;Complex;course development;Data;Detection;Development;Discrimination;Down's Syndrome;Education;Environment;Evaluation;executive function;experience;experimental study;Exposure to;Foundations;Funding;Goals;Hearing;hearing impairment;Heterogeneity;High Prevalence;improved;Individual;Individual Differences;infancy;Infant;Intervention;Knowledge;Language;Language Development;language outcome;Learning;Life;life span;Linguistics;Masks;non-Native;Outcome;Outcomes Research;parent project;peer;Perception;Persons;Population;Predisposition;Production;Public Health;Research;resilience;resilience factor;Risk Factors;School-Age Population;selective attention;Short-Term Memory;skills;sound;Source;Specific qualifier value;Speech;Speech Development;Speech Discrimination;speech in noise;Speech Perception;speech recognition;Speech Sound;Testing;Theoretical model;theories;therapy development;Time;Toddler;United States;United States National Institutes of Health;Vocation;Work;young adult

PROJECT_TITLE: SPEECH PERCEPTION AND AUDITORY ABILITIES IN INFANTS, CHILDREN, AND ADULTS WITH DOWN SYNDROME


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Extensive expansion of unconventional oil and gas development (UOGD) has been an emerging environmental health issue due to it proliferation and potential harmful health influence on nearby residents. Critical gaps in exposure assessments have prevented previous UOGD-related epidemiological studies from achieving credible and actionable evidence regarding the specific UOGD construction stage(s) or UOGD-related pollutant(s). I plan to enhance exposure assessment with remote sensing methods and evaluate the acute effects of UOGD construction stages on the risk of cause-specific hospitalization in Medicare beneficiaries based on the improved exposure metrics.

PI_NAMEs: LI, LONGXIANG  (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acceleration;Acute;Air Pollutants;Award;beneficiary;career;Chronic;cohort;Columbidae;Communities;Computer software;Crude Extracts;Data;Data Analyses;Decentralization;Development;Environment;Environmental Health;epidemiology study;exposure pathway;Exposure to;Funding;Gases;Generations;Health;Health Status;high resolution imaging;Hospitalization;Image;Image Analysis;Imagery;improved;Investigation;Measures;Mediating;Mediator;Medicare;Methods;Modeling;Monitor;Natural Gas;novel;Observational Study;Oils;open source;Outcome;Participant;Petroleum;Phase;pollutant;predictive modeling;prevent;Procedures;Process;Production;Proliferating;Proxy;Records;Refuse Disposal;remote sensing;Research Personnel;Resolution;Risk;Rural;rural area;Sentinel;Site;skill acquisition;skills;Source;spatiotemporal;temporal measurement;timeline;Training;Transportation

PROJECT_TITLE: Estimating acute impacts of unconventional oil and gas development on cause-specific hospitalization via satellite-based exposure assessment


NIH_SPENDING_CATS: Clinical Research;Eczema / Atopic Dermatitis;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative This study will investigate the expression, localization, and polymorphisms of the newly discovered Mas-related G protein-coupled receptor X3 (MrpgrX3) and IL-22 in the pathogenesis of itch in atopic dermatitis and prurigo nodularis in human patients. The results will be correlated with race, as these itch-associated skin diseases disproportionately affect African Americans. The results will provide new pathogenic insights and biomarkers for itch in distinct patient populations.

PI_NAMEs: KWATRA, SHAWN GAURAV (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;African American;African American population;Area;Atopic Dermatitis;Bilirubin;Biological Markers;Black Populations;Blood;burden of illness;Categories;Caucasians;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Chloroquine;Cholestasis;chronic itch;Clinical;cohort;Cutaneous;cytokine;Data;Dermatologist;Development;Disabling condition;Disease;Extensor;FDA approved;filaggrin;Flow Cytometry;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Expression;Gene Frequency;Genes;Genetic Polymorphism;Human;Immune system;Inflammatory;insight;interleukin-22;keratinocyte;Knowledge;loss of function mutation;Measures;Mediating;Mediator;nano-string;neural;new therapeutic target;novel;Pathogenesis;Pathogenicity;Pathway interactions;patient population;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Prurigo;Pruritus;Quality of life;Race;racial difference;Reaction;receptor;Reporting;Research;Role;Sampling;Severities;Single Nucleotide Polymorphism;Skin;skin biopsy;skin disorder;Sleep;Symptoms;T-Cell Activation;Testing;Therapeutic;therapeutic target;tissue biomarkers;transcriptome sequencing;translational study;United States;Up-Regulation;Variant;Visit;World Health Organization

PROJECT_TITLE: Racial Differences in Biomarkers and Therapeutic Targets for Chronic Itch

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative This proposal examines a means of providing potent anticoagulation within extracorporeal membrane oxygenation (ECMO) circuits without limiting normal coagulation in a patient’s tissues. To accomplish this, we propose combining polycarboxybetaine surface coatings with a highly selective bicyclic peptide Factor XIIa inhibitor. Together, these should improve survival during ECMO and enable long-term respiratory support outside the intensive care unit.

PI_NAMEs: COOK, KEITH E (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Adsorption;Affect;Albumins;Anticoagulants;Anticoagulation;artificial lung;Binding;Biocompatible Materials;biomaterial interface;Bleeding time procedure;Blood;Blood Platelets;Bolus Infusion;Cessation of life;Chronic lung disease;Clinical;clinical application;clinically relevant;Coagulation Process;Consumption;Custom;Cyclic Peptides;Data;Death Rate;Destinations;Dose;Drops;Effectiveness;efficacy evaluation;Emergency department visit;Engineering;Extracorporeal Membrane Oxygenation;Factor XIIa;Fibrinogen;Formulation;Gases;Goals;Half-Life;Hemorrhage;Heparin;Hour;Human;improved;In Vitro;in vivo;Inflammation;inhibitor;Intensive Care Units;Intravenous;intravenous drip;Life;Mechanical ventilation;Modeling;mortality;nanomolar;Normal tissue morphology;Oryctolagus cuniculus;Outcome;Oxygenators;Patients;Persons;Plasma Proteins;Plasmin;Plasminogen;Polyethylene Glycols;Proteins;Prothrombin time assay;Protocols documentation;Recovery;respiratory;restraint;Safety;sheep extracorporeal membrane oxygenation;Surface;surface coating;System;Technology;Thromboplastin;thrombotic complications;Time;Tissues;Transplantation;Venous

PROJECT_TITLE: Combined Use of Polycarboxybetaine Coatings with a Selective FXIIa Inhibitor to Create Potent Biomaterial Anticoagulation Without Bleeding During Extracorporeal Life Support

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: HIV testing remains the critical first step in achieving the 95-95-95 goals for HIV/AIDS treatment and prevention, yet testing rates are plateauing and more cost-effective strategies are needed to test higher-risk populations. We propose to leverage the ubiquity of mobile phones and the reach of social networks, to evaluate the efficacy and cost-effectiveness of a novel mHealth intervention, Confidential Social Network Referrals for HIV Testing (CONSORT), for ‘nudging’ high-risk populations to test for HIV. The autonomous, open-source, SMS-based approach can be scaled at minimal cost, is readily extensible to smartphone technologies and social media contexts, and holds significant potential to improve uptake of HIV testing and broadly shift paradigms for engaging social networks to change health-related behaviors.

PI_NAMEs: NJAU, BERNARD ;OSTERMANN, JAN  (contact);THIELMAN, NATHAN M

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Adherence;Adult;Algorithms;antiretroviral therapy;Appointment;Architecture;Area;arm;Awareness;Caring;Cellular Phone;Characteristics;Client;Clinic;Code;Collaborations;Communication;Contact Tracing;Continuity of Patient Care;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Counseling;Country;Data;Development;Diagnosis;digital;digital health;Disclosure;Eastern Africa;efficacy evaluation;Funding;Goals;Health behavior;Health system;Health Technology;high risk population;HIV;HIV diagnosis;HIV/AIDS;Human immunodeficiency virus test;improved;Incentives;incremental cost-effectiveness;indexing;Individual;Intervention;intervention cost;Legal;Link;low and middle-income countries;Methods;mHealth;mhealth interventions;Mobile Health Application;novel;novel strategies;open source;Participant;Partner Notification;patient oriented;Patients;Performance;Persons;Phase;pilot test;Play;Population;Prevalence;Prevention;primary outcome;Privacy;Provider;Randomized, Controlled Trials;Research;Resource-limited setting;Risk;Role;secondary outcome;Secure;Side;Site;social;social engagement;social media;Social Network;social stigma;Southern Africa;Specific qualifier value;System;Tanzania;Technology;Telephone;Testing;testing uptake;tool;transmission process;treatment center;United States National Institutes of Health;uptake;Viral;Work

PROJECT_TITLE: Confidential social network referrals for HIV testing (CONSORT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(56)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Despite global advances in technologies to prevent cervical cancer, roughly 90% of the burden of this preventable disease persists in LMICs. Along with the WHO’s call for elimination of cervical cancer within 100 years comes the need for effective innovations for expanding screening and completing follow-up triage and treatment. mHealth interventions integrated into existing HPV-based cervical cancer control programs may significantly impact patient health outcomes and provider engagement.

PI_NAMEs: ALMENDAREZ PERALTA, JUAN RAMON;INGERSOLL, KAREN S;MITCHELL, EMMA MCKIM (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;Acetic Acids;Adopted;Age;Awareness;Cancer Control;Cancer Etiology;cancer health disparity;Cancerous;Caribbean region;Cells;Cervical Cancer Screening;cervicovaginal;Clinic;Communities;community based participatory approach;community based participatory research;cost;cost effectiveness;Country;COVID-19;Cytology;design;Development;Disease;Early Diagnosis;Eligibility Determination;encryption;Enrollment;evidence base;Feasibility Studies;follow-up;Fright;Geographic Locations;Geography;girls;Health;health care availability;Health Insurance Portability and Accountability Act;health literacy;Health Personnel;high risk;human centered design;Human Papillomavirus;implementation/effectiveness;improved;innovation;International;Intervention;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Methods;mHealth;mhealth interventions;mobile application;Mobile Health Application;Modality;Modeling;Nicaragua;Nongovernmental Organizations;novel;Outcome;patient oriented;Patients;Phase;Pilot Projects;pilot test;Play;premalignant;prevent;primary outcome;Process;programs;Provider;provider portal;Public Health;Recommendation;Reporting;Research;research and development;Research Personnel;resilience;risk variant;Role;Rural;Scientist;screening;screening program;screening services;Self Efficacy;Surveys;survivorship;System;tailored health care;Technology;Testing;Time;tool;Triage;Universities;usability;Vaccination;Virginia;Visual;Woman;Women's mortality;World Health Organization

PROJECT_TITLE: Remote Resilience: Novel Applications of mHealth in Nicaragua's Cancer Control Program


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases;Telehealth;Vector-Borne Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE School-age school children in sub-Saharan Africa are most commonly infected with malaria parasites among other age groups, but their infections are often undiagnosed because of a lack of malarial testing commodities. Because malaria screening among school-age children is important to reduce malaria transmission and to improve school performance, our research focuses on developing a mobile health (mHealth) technology to reliably identify school-age children who will need malaria tests and receive treatment. The proposed mHealth technology will support community health workers and local health facilities by maximizing the currently available resources for malaria diagnosis and management, while improving children’s health and public health response, in particular in the developing world and resource-limited settings.

PI_NAMEs: KIM, YOUNG L (contact)

PROJECT_TERMS: 15 year old;Acute;Africa;Africa South of the Sahara;age group;Algorithms;Android;Anemia;Artemisinins;associated symptom;Biomedical Engineering;Blood;Cause of Death;Cellular Phone;Chemoprevention;Child;Child Health;clinically relevant;cognitive enhancement;cognitive function;Collection;Color;Combined Modality Therapy;community empowerment;Community Health Aides;Computational algorithm;cost effective;Country;Data;Data Collection;deep learning;Diagnosis;Diagnostic tests;digital;Doctor of Philosophy;Education;eHealth;Electronic Health Record;electronic health record system;Exclusion;Eyelid structure;Fever;Goals;Health;Health care facility;Health Technology;Healthcare Systems;Hemoglobin;Hemoglobin concentration result;human capital;imaging Segmentation;improved;Infection;Intervention;Investments;Learning;Machine Learning;Malaria;Malaria Diagnosis;Malaria Diagnostic;malaria infection;malaria transmission;Mass Screening;Measurement;Measures;Methods;mHealth;mobile application;Mobile Health Application;Modeling;Molecular;Paper;Parasites;Patients;Performance;Phase;Plasmodium falciparum;Play;Public Health;Rapid diagnostics;Reporting;Research;Resource-limited setting;Resources;response;Risk;risk stratification;Role;Rwanda;scale up;School-Age Population;Schools;screening;Spectrum Analysis;standard of care;statistical learning;Structure of palpebral conjunctiva;Technology;Telemedicine;Test Result;Testing;transmission process;ultra high resolution;Undifferentiated;Universities

PROJECT_TITLE: Risk stratification of malaria among school-age children with mHealth spectroscopy of blood analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(55)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: DUKE UNIVERSITY

PHR: A goal remains to develop a safe and effective preventative vaccine that protects people worldwide from acquiring HIV. GMP production of immunogens is important provide to HVTN for iterative phase 1 clinical trials to further vaccine development. One major target on the HIV Env for bnAbs is the V2 apex site

PI_NAMEs: HAYNES, BARTON F. (contact)

PROGRAM_OFFICER_NAME: SHAPIRO, STUART Z

PROJECT_TERMS: Antigens;Apical;B-Lymphocytes;Binding;Cell Lineage;Clinical Research;design;Development;Ferritin;Goals;HIV;HIV envelope protein;HIV Vaccine Trials Network;HIV-1;manufacture;Messenger RNA;Monkeys;nanoparticle;neutralizing antibody;Persons;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Preventive vaccine;Production;Proteins;research clinical testing;Research Personnel;Site;Testing;Toxicology;vaccine development

PROJECT_TITLE: Manufacture an mRNA/LNP encoding an HIV envelope designed to bind and stimulate multiple V2 Apex broadly neutralizing antibody B cell lineages


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: A goal remains to develop a safe and effective preventative vaccine that protects people worldwide from acquiring HIV. Down selection of immunogens in nonhuman primates allows us to advance vaccines to manufacturing for clinical testing.

PROJECT_TERMS: Antibodies;Antigens;B-Lymphocytes;Binding Sites;Cell Lineage;design;Development;Distal;Doctor of Philosophy;Epitopes;Genes;Germ Lines;Goals;HIV;HIV vaccine;HIV Vaccine Trials Network;Human;Immunization;Learning;Liposomes;Macaca;Macaca mulatta;manufacture;Messenger RNA;Monkeys;neutralizing antibody;nonhuman primate;Orthologous Gene;Peptides;Persons;Polysaccharides;Preventive vaccine;prototype;Recycling;Regimen;research clinical testing;Research Personnel;Rhesus;Specificity;Structure;UGT1A1 gene;vaccine trial;Vaccines

PROJECT_TITLE: Nonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodies


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative: Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity; yet there is no FDA-approved therapy for any stage of ALD and patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD. The existing resources of the NIAAA-funded AlcHepNet are used for patient studies, biospecimen collection and site-specific translational studies.

PI_NAMEs: MCCLAIN, CRAIG J. (contact);SINGAL, ASHWANI K;STEWART, CHRISTOPHER M

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinical;clinical center;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collection;Combined Modality Therapy;Compensation;Computers;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hospitals;improved;Individual;Informatics;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resource Allocation;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;translational study;Transplantation;treatment strategy;Zinc

PROJECT_TITLE: Integrated therapies for alcohol use and ALD (ITAALD) Network -UofL Clinical Center


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: Development of single immunogens capable of binding to multiple UCAs targeting both single Env bnAb epitopes and as well targeting multiple different bnAb epitopes is critical for ultimate design of a practical sequential protective HIV-1 vaccine.

PROJECT_TERMS: Antibodies;Antigenic Diversity;Antigens;Apical;B cell repertoire;B-Lymphocytes;Binding;Binding Sites;Cell Lineage;design;Development;Distal;Epitopes;Frequencies;Germ Lines;Goals;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immune system;improved;Individual;Infection;Membrane;neutralizing antibody;Peptides;Polysaccharides;Probability;Proliferating;Regimen;response;Site;transmission process;Vaccination;vaccination strategy;Vaccine Design;vaccine development;Virus

PROJECT_TITLE: HIV-1 Env immunogens that target unmutated common ancestor antibodies (UCAs)  of broadly neutralizing antibodies (bnAbs) reactive with multiple HIV-1 envelope epitopes


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PHR: A goal remains to develop a safe and effective preventative vaccine that protects people worldwide from acquiring HIV. Doing rapid iterative phase 1 clinical trials with our GMP production of immunogens is to further vaccine development.

PROJECT_TERMS: Antigens;B-Lymphocytes;Blood;Cell Lineage;Cells;Clinical Trials;design;efficacy evaluation;Evaluation;Frequencies;Genomics;Germ Lines;Goals;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Immunization;Immunologics;Leukapheresis;Medicine;Memory B-Lymphocyte;Persons;Phase I Clinical Trials;phase I trial;Population;Preventive vaccine;Production;Technology;Vaccination;Vaccine Clinical Trial;vaccine development

PROJECT_TITLE: Immunologic evaluation of HIV-1 HVTN experimental medicine trials HVTN 307, HVTN 309 and HVTN312


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: 2019-nCoV;Affinity;Antibodies;Antigens;Apical;Cell Line;cGMP production;Chimeric Proteins;Complex;Consumption;Cyclic GMP;design;Development;Evaluation;Ferritin;Genes;Goals;HIV;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;human pathogen;immunogenicity;Immunology;innovation;iterative design;Link;manufacture;Methods;nanoparticle;Nature;neutralizing antibody;Persons;Phase I Clinical Trials;preservation;Preventive vaccine;Process;Production;Proteins;Regimen;Reproducibility;Series;Site;sortase;Specificity;Surface;Technology;Time;vaccine development;Vaccines;Work

PROJECT_TITLE: Manufacture a protein encoding CAP256.wk34.c80 OPT4 envelope for induction of V2 Apex bnAbs


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_NAME: HAIMA THERAPEUTICS, LLC

PHR: Project Narrative Thrombocytopenia is a condition characterized by low platelet counts; patients with thrombocytopenia are at risk of excessive, uncontrollable bleeding. The current standard of care is transfusion with donor platelet products to mitigate bleeding risks. However, donor platelets are expensive, carry significant risk of infections, have variable hemostatic efficacy, and have very short shelf life (3-5 days). Our innovative SynthoPlateTM technology can mimic platelet’s hemostatic functions while providing advantages of large-scale production and sterilizability to reduce contamination risk and ensure long shelf life.

PI_NAMEs: BRUCKMAN, MICHAEL ARTHUR (contact)

PROJECT_TERMS: Affect;Age;Autoimmune Diseases;Biological Assay;Blood;Blood Platelets;Blood specimen;chemotherapy;Clinical;clinical application;clinical biomarkers;Clinical Protocols;Consumption;design;dosage;Dose;Drug Kinetics;Ensure;experimental study;Funding;Guidelines;Hemorrhage;Hemostatic Agents;Hemostatic function;high risk;Human;Idiopathic Thrombocytopenic Purpura;In Vitro;in vivo;infection risk;Injury;innovation;Intravenous;large scale production;Life;manufacture;mimetics;Minor;Modeling;Monitor;mouse model;Nanotechnology;Operative Surgical Procedures;Oryctolagus cuniculus;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacologic Substance;Phase;phase 2 study;Platelet Activation;Platelet Count measurement;Platelet Transfusion;Prevalence;product development;Production;prophylactic;Radiation therapy;research clinical testing;Risk;Site;Small Business Innovation Research Grant;Source;standard of care;success;Technology;Therapeutic;Therapeutic Agents;Thrombocytopenia;Transfusion

PROJECT_TITLE: SynthoPlate: Intravenous Hemostatic Nanotechnology to Mitigate Bleeding in Thrombocytopenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative: Alcohol-associated liver disease (ALD) is a leading cause of mortality/morbidity, and there is no FDA-approved therapy for any stage of ALD. Unfortunately, patients with ALD rarely have their underlying alcohol use disorder (AUD) concomitantly addressed. This consortium links health care providers with expertise in AUD and ALD in a unified treatment strategy to evaluate novel combined treatments for AUD/ALD in patients with advanced ALD. The existing resources of the NIAAA-funded AlcHepNet are used for patient studies, biospecimen collection and site-specific ancillary studies.

PI_NAMEs: MOELLER, FREDERICK GERARD;SANYAL, ARUN J (contact)

PROJECT_TERMS: acamprosate;Address;Adrenal Cortex Hormones;Affect;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;anakinra;Ancillary Study;antagonist;Antimicrobial Effect;Antioxidants;Apoptotic;Behavior Therapy;Behavioral;behavioral study;Biological Markers;Biological Specimen Banks;care outcomes;Caregivers;catalyst;Chimeric Proteins;Cirrhosis;Clinical;Clinical Data;Clinical Treatment;Clinical Trials;cohort;Collaborations;Collagen;Collection;Combined Modality Therapy;Compensation;Computers;Cyclophosphamide;Data;data repository;Databases;Diagnosis;Double-Blind Method;drinking;Early Intervention;Eligibility Determination;Enrollment;Evaluation;evidence base;FDA approved;Funding;Glucocorticoids;group counseling;Guidelines;Health Personnel;healthy volunteer;Heavy Drinking;Hepatitis;Hospitals;improved;Individual;Informatics;Infrastructure;Interleukin-1 Receptors;interleukin-22;Knowledge;Lactobacillus casei rhamnosus;Link;Liver;Liver diseases;longitudinal database;Masks;Measures;meetings;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;novel;novel therapeutics;Observational Study;open label;optimal treatments;Outcome;outcome prediction;patient population;Patient Preferences;patient registry;Patient-Focused Outcomes;Patients;Pattern;Pharmacotherapy;Phase;Phosphatidylethanolamine;Physicians;placebo controlled trial;Placebos;Prednisone;primary endpoint;prospective;Quality of Care;Quality of life;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Regression Analysis;Reporting;Research Design;Research Personnel;Resources;Safety;Site;social stigma;standard of care;Steroids;Systems Biology;Testing;Thinking;Translational Research;Transplantation;treatment strategy;Underserved Population;Universities;Virginia;Zinc

PROJECT_TITLE: Integrated Therapies for Alcohol use in Alcohol-associated Liver Disease (ITAALD) - Virginia Commonwealth University


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Lipoproteins are essential particles that transport fats to different cells in the brain. In individuals with Alzheimer's disease (AD), lipoproteins are not taken up by cells properly and instead bind to other factors outside the cell such as amyloid, leading to amyloid plaque formation, and damage to brain tissue and function. In this proposal, we aim to enhance the activity of the enzyme lipoprotein lipase (LPL), which can help specialized cells called microglia remove excess lipoproteins, prevent amyloid accumulation, and protect against the development of AD.

PI_NAMEs: BRUCE, KIMBERLEY D (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Abeta clearance;Acceleration;age related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer's neuropathogenesis;Amyloid;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Automobile Driving;Binding;Biology;Brain;brain tissue;Cells;Clinical;Data;design;Development;Disease;Disease Outcome;Disease Progression;Disease susceptibility;effective therapy;Endocytosis;enzyme activity;Enzymes;epidemiology study;Fatty acid glycerol esters;Functional disorder;gain of function;Gatekeeping;Genetic;genetic risk factor;Human;Hydrolysis;immune function;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Intervention;knock-down;Laboratories;Left;lipid metabolism;lipid transport;lipidomics;Lipids;lipoprotein lipase;lipoprotein lipase activators;Lipoproteins;loss of function;Love;Macrophage;Mediating;Metabolic;metabolic imaging;Metabolism;Microglia;Mus;Myeloid Cells;Neurodegenerative Disorders;neuroinflammation;novel;Onset of illness;particle;Phagocytes;Phagocytosis;pharmacologic;Play;Positioning Attribute;Prevalence;prevent;Process;Protein Isoforms;Publishing;Reporting;Research;Resolution;Role;Scaffolding Protein;Senile Plaques;small molecule;Structure;Supplementation;Testing;Therapeutic;therapeutic target;transcriptomics;uptake;Variant

PROJECT_TITLE: Targeting Microglial Lipoprotein Lipase in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

PHR: Project Narrative Understanding how the molecular components, inherited lineage, and spatial milieu of single cells dictate function in health and disease remains a key outstanding challenge in genomics. The overarching goal of our Center for Integrated Cellular Analysis is to develop methods to simultaneously assess these multimodal cellular properties, develop tools to harmonize them to allow inferential assessment of cell identity based on partial phenotyping, and share these developments with the broad scientific community while encouraging community engagement through education and outreach. Success in our strategy will facilitate deep, multi-omic phenotyping of single cells for basic research and clinical applications.

PI_NAMEs: LANDAU, DAN ;SATIJA, RAHUL  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Academic Training;Address;analytical method;Basic Science;Biological Assay;biological systems;cell behavior;Cell Lineage;Cells;clinical application;Communities;community engagement;Complex;Computer software;Data;data integration;Development;Disease;Education;Education and Outreach;Environmental Risk Factor;Genomics;Goals;gustin;Health;Human body;Inherited;Measurement;Measures;Methods;Mission;Modality;Molecular;multimodality;multiple omics;New York City;Phenotype;Population;Property;Protocols documentation;Resource Sharing;Role;Series;single-cell RNA sequencing;success;Systems Biology;Taxonomy;Technology;tool;Underrepresented Students

PROJECT_TITLE: Center for Integrated Cellular Analysis - Sophie Gustin


PROJECT_TERMS: Academic Training;Address;analytical method;Basic Science;Biological Assay;biological systems;cell behavior;Cell Lineage;Cells;clinical application;Communities;community engagement;Complex;Computer software;Data;data integration;Development;Disease;Education;Education and Outreach;Environmental Risk Factor;Genomics;Goals;Health;Human body;Inherited;Measurement;Measures;Methods;Mission;Modality;Molecular;multimodality;multiple omics;New York City;Phenotype;Population;Property;Protocols documentation;Resource Sharing;Role;Series;single-cell RNA sequencing;success;Systems Biology;Taxonomy;Technology;tool;Underrepresented Students

PROJECT_TITLE: Center for Integrated Cellular Analysis - Christopher Zavala


PROJECT_TITLE: Center for Integrated Cellular Analysis - Olivia Taylor


PROJECT_TITLE: Center for Integrated Cellular Analysis - Alisha Aristel


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Comparative Effectiveness Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

PHR: PUBLIC HEALTH NARRATIVE Congenital cardiac anomalies represent the most common birth defect, affecting nearly 1% of all live births and despite significant advances in their surgical and medical management, these conditions remain a leading cause of death and disability in the newborn period. One significant source of morbidity and mortality arises from complications associated with the use of currently available prosthetic vascular grafts, cardiovascular patches, and replacement heart valves that are frequently required to perform reconstructive procedures. Tissue engineering offers a potential strategy for creating improved biomaterials for use in congenital heart surgery.

PI_NAMEs: BREUER, CHRISTOPHER KANE (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;4D MRI;Acetylcholine;Adolescent;Affect;Age;Angiography;Animal Model;Animals;Autologous;Biocompatible Materials;Blood flow;Blood Vessel Prosthesis;Blood Vessels;calcification;Cardiac;Cardiovascular system;Caring;Cause of Death;Characteristics;Child;Cine Magnetic Resonance Imaging;Clinic;Clinical;Clinical Trials;cohort;Common Ventricle;comparative efficacy;Congenital Abnormality;congenital heart abnormality;Congenital Heart Surgery;Coupled;Data;design;Development;Devices;disability;Disease;Dobutamine;Dose;Electric Capacitance;Fontan Procedure;Functional Regeneration;Geometry;Goals;Grant;Growth;heart valve replacement;Heart Ventricle;hemodynamics;Image;Implant;implantation;improved;improved outcome;in vivo;Inferior vena cava structure;Investigation;life span;Liquid substance;Live Birth;Measures;Medical;Modeling;Monitor;Morbidity - disease rate;morphometry;mortality;Natural regeneration;Newborn Infant;Nitroglycerin;Norepinephrine;operation;Operative Surgical Procedures;Orphan;Performance;pharmacologic;Physiological;Polytetrafluoroethylene;Postoperative Complications;pre-clinical;preclinical study;pressure;prevent;Procedures;Property;Prosthesis;Public Health;Pulmonary artery structure;Reagent;Regulatory Pathway;repaired;Resistance;respiratory;response;Rest;Risk;Safety;scaffold;sex;Sheep;sheep model;Source;standard of care;Stress;Stress Tests;Technology;Testing;Time;Tissue Engineering;Tissues;Translating;ultrasound;Vascular Graft;vascular tissue engineering;vasoconstriction;Vasodilation;Ventricular Function;Work;X-Ray Computed Tomography

PROJECT_TITLE: A Preclinical Study Evaluating and Comparing the Efficacy of Tissue Engineered Vascular Grafts to Polytetrafluoroethylene Grafts


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE While it is now accepted that cell-to-cell variability affects viral infection outcome, we currently lack mechanistic understanding as to the host factors and transcriptional programs that control it. To gain such mechanistic insights requires the development of new approaches that are able to connect the cell’s initial state with infection outcome. This project will develop and apply state-of-the-art single cell approaches to decipher the molecular mechanisms that control viral infection outcomes at the single cell level.

PI_NAMEs: DRAYMAN, NIR  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Affect;Anti-viral Response;Anti-viral Therapy;Award;Biological Models;Biology;Cell Fraction;Cells;Cellular biology;cellular imaging;Collaborations;Custom;Data;design;Development;doctoral student;Gene Expression;Genetic Transcription;Germ Cells;Goals;Herpesvirus 1;high reward;high risk;improved;Infection;Infection Control;innovation;insight;Integration Host Factors;Investments;Life Cycle Stages;Literature;live cell imaging;Machine Learning;machine learning algorithm;Measurement;Methodology;Microfluidic Microchips;Microfluidics;Modality;Modeling;Molecular;Monitor;National Institute of Allergy and Infectious Disease;NF-kappa B;novel;novel strategies;Outcome;pathogen;pathogenic virus;Pathway interactions;Phenotype;Positioning Attribute;Probability;Process;Production;Productivity;programs;rational design;Research;Research Personnel;Resources;Science;secondary infection;Shapes;single-cell RNA sequencing;Supervision;System;Systems Biology;Technology;Testing;Therapeutic;Time;Titrations;TNF gene;tool;transcription factor;Validation;Viral;Viral Genes;virology;Virus;Virus Diseases;virus genetics;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Harnessing cell-to-cell variability to understand viral infection outcomes


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: This project investigates the effects of Neuropeptide Y (NPY), a peptide made by inhibitory neurons in the brain, on the function of the hippocampus, a part of the brain important for learning, memory, and mood regulation. NPY is known to have anti-anxiety properties and to be protective against stress, although our knowledge about the mechanisms underlying its effects is incomplete. The proposed studies will enhance our understanding of the underlying synaptic and circuit mechanisms by which NPY in hippocampus alters stress- related behavior and affects how the brain responds to traumatic stress, and may lead to new therapeutic targets for complex brain disorders such as anxiety disorders and post-traumatic stress disorder.

PI_NAMEs: DOBRUNZ, LYNN E (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Affect;Amygdaloid structure;Animals;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;anxiety symptoms;Attenuated;avoidance behavior;Axon;Bathing;Behavior;behavior test;Behavioral;Behavioral Symptoms;Brain;Brain Diseases;Cells;Clinical Research;Complex;Data;Dense Core Vesicle;depressive symptoms;designer receptors exclusively activated by designer drugs;Electrophysiology (science);entorhinal cortex;experimental study;Exposure to;Fright;Functional disorder;Funding;Genetic;genetic approach;Goals;Grant;Hippocampus;Human;Impairment;improved;inhibitory neuron;Injections;Knowledge;Learning;Location;Measures;Mediating;Memory;memory consolidation;Mental Depression;Methods;Modeling;mood regulation;Mus;neuropeptide Y;Neuropeptide Y Receptor;neuroregulation;new therapeutic target;novel strategies;novel therapeutic intervention;optogenetics;Pathway interactions;Patients;Peptides;pharmacologic;Pharmacology;Physiological;Post-Traumatic Stress Disorders;postsynaptic;preclinical study;preservation;prevent;Property;receptor;recruit;resilience factor;response;Rodent;Rodent Model;Sensory;Signal Transduction;Slice;spatiotemporal;Stress;stress reduction;stress resilience;Study models;Synapses;synaptic function;Testing;Training;traumatic stress;treatment of anxiety disorders

PROJECT_TITLE: Effects of NPY on Hippocampal Circuit Function


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Survival rates for many childhood and adolescent cancers have improved at a remarkable pace over the past five decades. The Childhood Cancer Survivor Study (CCSS; U24 CA055727; PI: Armstrong) cohort has been the source of some of the most significant publications to date addressing the long-term mortality, morbidity and quality of life of survivors of childhood cancer. Understanding the risk for late effects of childhood cancer and its therapy provides the basis for health screening recommendations and interventions that can mitigate long-term health problems in this high-risk population.

PI_NAMEs: ARMSTRONG, GREGORY  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Adolescent;biobank;Blood specimen;Cancer Survivor;Child;Childhood;childhood cancer survivor;Childhood Cancer Survivor Study;cohort;deep sequencing;Diagnosis;Disease susceptibility;DNA sequencing;Eligibility Determination;follow-up;Genetic Predisposition to Disease;Genotype;Health;health related quality of life;Hematopoiesis;high risk population;improved;Institution;Intervention;Investigation;Late Effects;Malignant Childhood Neoplasm;Malignant Neoplasms;Morbidity - disease rate;mortality;multidisciplinary;Mutation;Outcome;Participant;Publications;Quality of life;recruit;Research;Research Personnel;Resources;Risk;screening guidelines;SNP array;Source;Survival Rate;Survivors;survivorship

PROJECT_TITLE: Enhance the CCSS biospecimen resource through characterization of clonal hematopoiesis among survivors of childhood cancer


ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Naïve T cell numbers are dramatically decreased with age, leading to impaired immune responses in the elderly. Naïve T cells rely on signals from the lymph node tissue environment to survive, yet it is unknown whether this support is reduced with age. This project will determine how age-related changes to the structural organization of the lymph nodes contributes to reduced naïve T cell survival.

PI_NAMEs: LANCASTER, JESSICA N (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Age;age effect;age related changes;age related decline;aged;Aging;Architecture;Automobile Driving;CCL21 gene;Cell Count;Cell Differentiation process;Cell Survival;cell type;Cells;chemokine;Communicable Diseases;cytokine;Data;Elderly;Environment;Frequencies;Goals;Homeostasis;Human;Immune;Immune response;Impairment;In Situ;Infection;Link;lymph node microenvironment;Lymph Node Tissue;lymph nodes;lymphotoxin beta;lymphotoxin beta receptor;migration;Motility;Mus;pathogen;Population Decreases;Process;recruit;Reticular Cell;Role;Signal Transduction;Stromal Cells;Structure;T-Lymphocyte;therapeutic development;Time;Tissues;two photon microscopy;Visualization;Work

PROJECT_TITLE: Diversity Supplement:  The role of lymph node structural organization in naive T cell decline with age

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Understanding how skin commensal bacteria shape pathogenic MAIT cell responses is essential to elucidating the pathogenic mechanisms in lupus skin, characterized by disbyosis and notable T cell presence. This application directly addresses the NIH Stephen Katz funding opportunity as it proposes an innovative project that represents a change in research direction, while also supporting the programmatic objectives of the NIAMS Skin Biology and Diseases program. In addition to advancing the understanding of the immune cell – microbiome interactions in lupus skin, these studies will define targetable pathways to prevent lupus skin disease, thus addressing the NIH’s mission to enhance health and reduce the burden of illness.

PI_NAMEs: SKOPELJA-GARDNER, SLADJANA  (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Address;Affect;Area;Autoimmune Diseases;Bacteria;Biology;Blood;burden of illness;Cause of Death;CD8B1 gene;Cell Physiology;Cells;Cellular biology;Circulation;Clonal Expansion;commensal bacteria;Coupled;Cutaneous;cytokine;cytotoxic;Data;Dermal;Development;direct application;Disease;experience;Frequencies;Funding Opportunities;Gene Expression;Genus staphylococcus;Goals;Health;Heterogeneity;Human;IL17 gene;Immune;immune activation;Immune response;Immunologics;in vivo;Inbred MRL lpr Mice;Inflammatory;inhibitor;innovation;Investigation;Kidney;Knowledge;Ligands;Lupus;lupus cutaneous;Lymphocyte;Mediating;microbial community;microbiome;microbiome alteration;migration;Mission;mortality;mouse model;Mucous Membrane;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Organ;Outcome;Participant;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Photosensitivity;Population;prevent;programs;Property;Proteomics;Reaction;recruit;Reporting;Research;Research Personnel;Resources;response;Riboflavin;Role;Sampling;Shapes;Signal Transduction;single-cell RNA sequencing;Skin;Skin colonization;skin disorder;Skin injury;skin lesion;skin microbiome;skin microbiota;skin organogenesis;Staphylococcaceae;stem;Sunlight;Systemic Lupus Erythematosus;T-Lymphocyte;Testing;Therapeutic;tissue injury;Tissues;transcriptomics;Translational Research;ultraviolet;Ultraviolet Rays;United States;United States National Institutes of Health;young woman

PROJECT_TITLE: MAIT cells in lupus skin disease and photosensitivity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Wound Healing and Care

ORG_DEPT: PHYSICS

PHR: Project Narrative  The effective treatment of bacterial infections of skin, deep soft tissues and wounds continues to be a major unmet healthcare challenge, especially in patients whose antimicrobial responses are compromised by underlying diabetes. The proposed work seeks to establish a new class of antimicrobials, inspired by immune cells, that are synergistic through the combination of histones with agents that target the outer surface of bacteria. The successful outcome of this work would provide fundamental insight into a novel antimicrobial mechanism and produce important pre-clinical data for the development of new therapeutics that treat skin, soft tissue, and wound infections.

PI_NAMEs: SIRYAPORN, ALBERT  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;anti-microbial peptide;Antibiotic Resistance;Antibiotics;antimicrobial;antimicrobial peptide LL-37;Attention;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bactericide;Bacteriology;Biology;Biophysics;cathelicidin;cathelicidin antimicrobial peptide;Cell Wall;Cells;Cellular biology;Cessation of life;Chemicals;Chronic;chronic wound;combat;Communities;Cryoelectron Microscopy;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;DNA;effective therapy;Engineering;experimental study;extracellular;Fiber;Foundations;Gene Expression;Goals;health care settings;Healthcare;Histone H2A;histone modification;Histones;Human;human pathogen;Immobilization;Immune;Immunology;In Vitro;in vivo;Infection;Infectious Skin Diseases;inhibitor;innovation;insight;Interdisciplinary Study;Malignant Neoplasms;Measures;Membrane;methicillin resistant Staphylococcus aureus;microbial;microbial community;Modeling;Modernization;Modification;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;neutrophil;next generation;non-diabetic;non-healing wounds;novel;novel strategies;novel therapeutics;Outcome;pathogen;pathogenic bacteria;Pathway interactions;Patients;Peptidoglycan;pre-clinical;Proliferating;Pseudomonas aeruginosa;ramoplanin;Reporting;Resistance;resistant strain;response;scaffold;Shapes;Skin;skin wound;soft tissue;Soft Tissue Infections;Standardization;Staphylococcus aureus;Surface;synergism;targeted agent;Testing;Therapeutic;uptake;Work;wound;Wound Infection

PROJECT_TITLE: Synergistic killing of bacterial pathogens by histones

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]