NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Chronic uncontrolled hypertension (HTN) impacts millions in the United States, with disproportionate deaths and morbidity affecting racially/ethnically minoritized populations, particularly Black and Latinx patients. Though the COVID-19 pandemic has prompted adoption of telehealth for chronic disease care, many racially/ethnically minoritized patients have inequitable access to health IT (patient portals, telemedicine video visits, and remote patient monitoring) due to structural, clinical, and individual barriers; addressing equitable telehealth access could reduce the “digital divide,” improve chronic disease self-management, and enhance health outcomes. Our team is located in a large, racially and ethnically diverse public health network, where we propose to implement a multilevel randomized controlled trial including clinic-level practice facilitation (learning collaborative, community advisory boards, and telehealth data dashboard), and patient-level health coaching and digital navigation, to enhance patient digital literacy, medication adherence, self-efficacy for HTN care and increase patient and clinician engagement with health IT, thereby improving hypertension control and reducing health disparities in care for Black and Latinx patients.

PI_NAMEs: TUOT, DELPHINE  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adoption;Adult;Affect;American;Appointment;arm;Asian;Black Populations;Black race;Blood Pressure;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;care delivery;Caring;Cessation of life;Child Care;Chronic;Chronic Care;Chronic Disease;Chronic Kidney Failure;Clinic;Clinical;clinical care;Communication;community advisory board;Community Health Aides;Competence;COVID-19 pandemic;dashboard;Data;data dashboard;Development;Devices;Diabetes Mellitus;digital;digital divide;digital health;digital technology;Disease Management;Disease Outcome;Disparity;Ecosystem;Effectiveness;Electronics;Equity;ethnic disparity;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;experience;Face;Federally Qualified Health Center;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health;health care delivery;health care disparity;health data;health disparity;health equity;Health Technology;Healthcare;Hypertension;hypertension control;implementation determinants;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation strategy;improved;Individual;Inequity;interest;Internet;Intervention;Interview;Latinx;Latinx population;Learning;Linguistics;literacy;Low income;low socioeconomic status;marginalization;medication compliance;Methods;Microalbuminuria;Minority Groups;minority patient;Modality;Morbidity - disease rate;mortality;multidisciplinary;operation;Outcome;outcome disparities;pandemic disease;patient engagement;patient level intervention;patient oriented;patient portal;Patient Preferences;patient-level barriers;Patients;Persons;preference;primary outcome;Process;Process Measure;programs;Provider;Public Health;Race;racial disparity;racial diversity;racial minority;racial minority population;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;remote patient monitoring;Risk Factors;Role;safety net;San Francisco;Self Efficacy;Self Management;shared decision making;skills;skills training;socioeconomic disparity;Spanish/English;Stroke;System;Technology;telehealth;Telemedicine;Telephone;tool;Training Support;Transportation;treatment as usual;United States;video visit;Visit;Voice;Work

PROJECT_TITLE: ACCTiVATE: Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-F(90)S]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This research will increase knowledge about the regulation of gene expression, which underlies virtually every aspect of human health. By improving understanding of RNA polymerase, which is an established target for effective antibiotics, the work will aid in the quest for new antibiotics that can keep humankind a step ahead of microbial pathogens. The research also will elucidate complex connections between RNA synthesis by RNA polymerase, chromatin structure, RNA maturation, and RNA translation that are key to understanding the function of microbial communities in promoting both human health and disease.

PI_NAMEs: LANDICK, ROBERT  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Abbreviations;Actinobacteria class;Affect;Amino Acids;Anti-sense RNA;Antibiotics;antimicrobial;Bacillus subtilis;Bacteria;Bacterial Chromosomes;Bacterial RNA;Bacteroides fragilis;Behavior;Biochemical;Biogenesis;Biological Assay;Biotechnology;C-terminal;Catalysis;Chromatin;Chromatin Structure;Chromosome Structures;Clostridium difficile;Closure by clamp;Complement;Complex;Consensus;Coupled;Coupling;Cryoelectron Microscopy;Disease;DNA;DNA Insertion Elements;DNA-Directed RNA Polymerase;ds-DNA;Elements;Escherichia coli;Eukaryota;Family;Filament;Firmicutes;Gene Expression Regulation;Gene Silencing;gene therapy;genetic approach;Genetic Transcription;genome-wide;Goals;Growth;Health;Hi-C;Human;improved;In Vitro;in vivo;insight;Interferometry;Knowledge;Link;Mediating;Medicine;Methods;Microbe;microbial community;Modeling;Molecular;Molecular Biology;Molecular Chaperones;Molecular Conformation;Molecular Structure;mycobacterial;Mycobacterium tuberculosis;N-terminal;Nucleoproteins;Nucleotides;paralogous gene;pathogenic microbe;Positioning Attribute;premature;Prokaryotic Cells;Proteobacteria;recruit;Regulation;Reporter;Research;Ribosomes;RNA;RNA chemical synthesis;RNA Folding;Role;Rotation;Signal Transduction;single molecule;Spectrum Analysis;Structure;System;Transcription Elongation;transcription factor;Transcriptional Regulation;Translations;Triplet Multiple Birth;virtual;Work;Y protein

PROJECT_TITLE: Structure/Function of Transcription Complex Regulation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: RAYENS, MARY KAY (contact)

PROJECT_TERMS: analytical method;analytical tool;Appalachian Region;Area;Authorization documentation;Biometry;Biostatistics Core;Cancer Center;career;Characteristics;Cities;cohort;Collaborations;community collaboration;Community Outreach;County;dashboard;Data;data access;Data Collection;data dictionary;Data Files;data format;data infrastructure;data integration;Data Mart;Data Security;data sharing;data standards;data warehouse;Development;Documentation;Education;Ensure;experience;Future;Goals;Informatics;Information Centers;Information Dissemination;Information Sciences;instrument;Kentucky;Measures;Participant;participant enrollment;patient engagement;Patient Recruitments;peri-urban;PhenX Toolkit;Pilot Projects;Probability;Probability Samples;query tools;recruit;Reporting;Research;Research Design;Resource Informatics;Resources;response;Rural;Rural Community;rural counties;Sampling;Science;Secure;Security;socioeconomic disadvantage;Staging;Standardization;Statistical Data Interpretation;Structure;structured data;Surveys;synergism;Technology;timeline;tobacco products;tobacco regulatory science;tool;unstructured data;web site;Weight;Work

PROJECT_TITLE: AppalTRuST Biostatistics and Informatics Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-R]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: GOLDEN, SHELLEY  (contact)

PROJECT_TERMS: Affect;Award;Behavioral Sciences;Biostatistical Methods;Black Populations;career;career development;Centers for Disease Control and Prevention (U.S.);Clinical Medicine;Collaborations;Communication;Competence;Development;Development Plans;Disparity;doctoral student;Electronic cigarette;Eligibility Determination;Environment;evidence base;experience;Faculty;faculty mentor;Feedback;Funding;Goals;Grant;Health;health communication;Health Disparities Research;health disparity;health equity;Health equity research;Health Policy;improved;Income;innovation;investigator training;Journals;K-Series Research Career Programs;Lead;Lesbian Gay Bisexual;Measures;meetings;member;Mentors;Mentorship;microaggression;National Cancer Institute;Nicotine;North Carolina;Occupations;Outcome;Persons;Pilot Projects;Population;Positioning Attribute;Postdoctoral Fellow;Poverty;pre-doctoral;Process;Program Research Project Grants;programs;Psychology;Publications;recruit;Reduce health disparities;Regulation;Research;research faculty;Research Methodology;Research Personnel;Research Project Grants;satisfaction;Science;senior faculty;Services;skill acquisition;skills;Societies;student mentoring;Supervision;symposium;System;Tobacco;tobacco control;tobacco flavor;tobacco products;tobacco regulatory science;Tobacco use;Training;training opportunity;Training Programs;United States National Institutes of Health;Universities;Writing;young adult;Youth

PROJECT_TITLE: Career Enhancement Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE One influential theory of how Alzheimer’s disease spreads in the brain is that toxic tau is transported through the brain’s white matter, along the axons of neurons; however, evidence for this model is incomplete. If axonal transport is a common mechanism of tau spread, it should leave behind a signature of tau accumulation and degeneration affecting the white matter networks that correspond to a patient’s primary cognitive symptoms. We will combine longitudinal imaging of tau progression and white matter change with postmortem histopathology to assess evidence for the axonal transport model in amnestic and non-amnestic variants of Alzheimer’s disease that are known to affect distinct cognitive networks.

PI_NAMEs: PHILLIPS, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adult;Affect;Age;age related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amnestic Disorder;Amyloid beta-Protein;Anatomy;Anisotropy;Antibodies;Area;Atrophic;Attention;Attenuated;Autopsy;Award;Axon;Axonal Transport;Biology;biomarker identification;Brain;burden of illness;cerebral atrophy;Cerebrovascular Disorders;Characteristics;Clinical;clinical diagnosis;clinical heterogeneity;clinical phenotype;Cognition Disorders;Cognitive;Complex;corticobasal syndrome;Data;Data Set;Deposition;Diffusion Magnetic Resonance Imaging;digital;Disease;Disease Progression;disorder risk;Episodic memory;Exhibits;Fast Blue;follow-up;gray matter;Hemorrhage;Heterogeneity;Histopathology;Human;Image;image guided;imaging biomarker;Impaired cognition;Impairment;improved;in vivo;Individual;Influentials;Investigation;Language;Link;Liquid substance;longitudinal positron emission tomography;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Memory;Methods;Microvascular Dysfunction;mild cognitive impairment;Modeling;Molecular;Molecular Conformation;mouse model;MRI Scans;multimodality;Mus;Myelin;neocortical;Nerve Degeneration;Neurobehavioral Manifestations;Neurofibrillary Tangles;Neurons;Nodal;Pathologic;Pathologic Processes;Pathology;Patients;Pattern;Phenotype;Positron-Emission Tomography;predictive modeling;Predisposition;Primary Progressive Aphasia;prognostic model;Radial;Recovery;Research;Resolution;Risk Factors;serial imaging;sex;Source;Stress;support network;Syndrome;tau aggregation;tau Proteins;Testing;theories;Time;Tissue Sample;Validation;Variant;Vascular Diseases;Visuospatial;white matter;white matter change;White Matter Hyperintensity

PROJECT_TITLE: Spreading Tau Pathology in Non-Amnestic Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation;Telehealth

ORG_CITY: MAPLE GROVE

ORG_NAME: MOAI TECHNOLOGIES, LLC

ORG_STATE: MN

PHR: Project Narrative Preventing Alzheimer’s disease (AD) is arguably the most important approach to address the dementia epidemic worldwide because 99.6% of drug trials failed and no drugs can yet prevent, cure, or even slow AD. Growing evidence suggests that aerobic exercise and cognitive training, particularly in combination, are two such promising interventions to target cognitive decline in persons at risk for AD, however compliance to such therapies in the real world setting is poor due to travel and time barriers. This proposed project will implement and test a unique Virtual Reality Cognitive Training (VRCT) combined with concurrent cycling (Exergame) that seamlessly integrates specific cognitive tasks into a virtual environment and is synchronized with cycling to promote cognitive gains, in a home-based (asynchronous) telerehabilitation model in a 2:2 factorial design clinical trial in persons at risk for AD.

PI_NAMEs: OLOFINBOBA, OLU  (contact);SALISBURY, DERECK L

PROGRAM_OFFICER_NAME: HETTINGER, JANE CECELIA

PROJECT_TERMS: Address;Adherence;Aerobic;Aerobic Exercise;Affect;Alzheimer's Disease;Alzheimer's disease risk;American;arm;Attention;Behavior Therapy;Biological Markers;Blood;Businesses;Clinical Trials;Clinical Trials Design;Cognition;Cognitive;cognitive task;cognitive training;combat;Combined Modality Therapy;commercialization;Communities;community setting;cost;cost effective treatment;COVID-19 pandemic;Dementia;design;Disease;Dose;Double-Blind Method;efficacy evaluation;Environment;Epidemic;Exercise;exercise training;exergame;experience;flexibility;Habilitation;Home;Impaired cognition;improved;Individual;innovation;Intervention;intervention delivery;Laboratories;Liquid substance;Measures;Minnesota;Modeling;neuroprotection;Nonpharmacologic Therapy;novel;older adult;Outcome;Participant;Performance;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Populations at Risk;preference;preservation;prevent;Prevention strategy;Preventive Medicine;primary outcome;processing speed;programs;Psyche structure;Randomized;Rehabilitation therapy;Reporting;Research Project Grants;Risk;satisfaction;Science;secondary outcome;Small Business Innovation Research Grant;Technology;telerehabilitation;Testing;Therapeutic;therapy design;Time;Travel;Universities;Update;usability;user-friendly;virtual environment;virtual reality;Work

PROJECT_TITLE: Concurrent Aerobic Exercise and Cognitive Training to Prevent Alzheimer's in at-risk Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PI_NAMEs: SPRATT, THOMAS E (contact)

PROJECT_TERMS: Acute;addiction;Address;Aerosols;Affect;animal data;Animal Model;Animals;Biological;Biological Markers;biomarker development;biomarker validation;Blood;Characteristics;Chemicals;Cigarette;Cigarette Smoker;cold temperature;combustible cigarette;Crossover Design;Data;design;Development;Devices;e-cigarette aerosols;Electronic cigarette;electronic cigarette user;electronic liquid;Epithelium;Exhalation;Exposure to;Flavoring;Free Radicals;Future;Health;Health Personnel;High temperature of physical object;Home;Human;In Vitro;in vivo;Individual;Inflammation;Inhalation;Inhalation Exposure;innovation;Link;lipidomics;Liquid substance;Lung;Mainstreaming;Marketing;Measures;mouse model;Mus;Nicotine;Normal Range;Nose;novel;novel marker;oxidant stress;Oxidants;Oxidative Stress;Participant;Perception;Physical condensation;Policy Maker;Population Study;Production;Propylene Glycols;Pulmonary Inflammation;Randomized;Recommendation;recruit;Research;Research Personnel;Risk;Safety;Sampling;Site;Smoker;Solvents;specific biomarkers;Temperature;Testing;tobacco exposure;tobacco products;Tobacco smoke;Toxic effect;Toxicant exposure;Translating;translational approach;translational study;Urine;Variant;Visit

PROJECT_TITLE: Project 1: Translational Studies on Temperature and Solvent Effects on Electronic Cigarette-Derived Oxidants


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: ADDY, NII A (contact)

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adult;Affect;Age;age difference;Behavior;Biological Assay;Biological Markers;Brain;Calcium;Chemicals;Cigar;Cigarette;cigarillos;conditioning;Data;Dependence;Dopamine;drinking;Electronic cigarette;electronic liquid;enantiomer;Exposure to;Foundations;genetic approach;Glycerol;Human Cloning;Ice;Intake;Irritants;irritation;Life;Link;Maintenance;Measures;Menthol;Mission;Modeling;Mus;neurochemistry;Nicotine;nicotine reward;nicotine seeking behavior;nicotine use;nicotine vapor;Odors;Oral;oral sensory;Outcome;Perception;Plethysmography;preconditioning;preference;Prevalence Study;Property;Propylene Glycols;Psychological reinforcement;Public Health;Rattus;receptor;respiratory;response;Rewards;Rodent;Role;Self Administration;Sensory;sex;Smokeless Tobacco;Solvents;Stereoisomer;sugar;sweet taste perception;Sweetening Agents;System;Taste Buds;Taste Perception;Testing;Tobacco;tobacco flavor;tobacco products;Tobacco use;vanillin;vapor;Withdrawal;Youth

PROJECT_TITLE: Beyond characterizing flavors: Effects of odorless constituents (sensory additives, solvents, and synthetic nicotine) on tobacco product use behaviors from adolescence to adulthood


PI_NAMEs: MUSCAT, JOSHUA E (contact)

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Acetaldehyde;Acetates;Acrolein;addiction;Address;Affect;Aromatic Polycyclic Hydrocarbons;authority;behavior measurement;Biological;Biological Markers;C-reactive protein;Carcinogens;Cellulose;Centers for Disease Control and Prevention (U.S.);Characteristics;Chemicals;Cigar;Cigarette;Cigarette Smoker;combustible cigarette;Cross-Over Studies;Data;density;design;Development;e-cigarette aerosols;Electronic cigarette;environmental tobacco smoke exposure;Exhalation;exposed human population;Free Radicals;Gases;Goals;Health;Hispanic;Human;Hydrogen Peroxide;Inflammation;inflammatory marker;Intercellular adhesion molecule 1;Interleukin-6;Isoprostanes;Knowledge;Laboratories;Length;Linear Models;low socioeconomic status;Mainstreaming;Measures;men;Methods;Mission;Modeling;Nicotine;Nitrates;Nitrosamines;Output;Oxidants;Oxidative Stress;Particulate;Persons;Phase;Physical condensation;Population;Price;Production;Protocols documentation;Randomized;Regulation;Research Design;Rod;Sampling;secondary outcome;Shapes;Smoke;Smoker;Smoking;Testing;Tobacco;Tobacco Dependence;tobacco exposure;tobacco products;Tobacco smoke;Toxic effect;toxicant;Variant;ventilation;Weight

PROJECT_TITLE: Project 2: Oxidative Stress and Harmful Constituent Levels Associated with Little Cigars


PI_NAMEs: SOFUOGLU, MEHMET  (contact)

PROJECT_TERMS: abuse liability;addiction;addiction liability;Address;Behavior;behavioral pharmacology;behavioral study;Benchmarking;Characteristics;Chemicals;Cigarette;Cigarette Smoker;cigarette smoking;Clinical Research;Clinical Trials;Dependence;Detection;Development;Discrimination;Dose;drug discrimination;Drug Kinetics;Electronic cigarette;electronic liquid;Female;Human;Individual;Infusion procedures;Inhalation;interest;Intravenous;Intravenous infusion procedures;Knowledge;male;Metabolism;Methods;Modeling;Nicotine;nicotine inhalation;nicotine self-administration;novel;Outcome;Participant;Physiologic pulse;Pilot Projects;placebo controlled study;Population;Potassium;pre-clinical research;preclinical study;prevent;Procedures;prototype;Psychological reinforcement;recruit;response;Rewards;Risk;Route;Saline;Sampling;Science;Self Administration;Sensory;Series;sex;Smoker;Smoking;Stimulus;Sucrose;Sweetening Agents;Testing;Tobacco;Tobacco Dependence;tobacco products;Tobacco use;Work;young adult;Youth

PROJECT_TITLE: Addictive Threshold of Nicotine and the Impact of Sweeteners


PI_NAMEs: FOULDS, JONATHAN  (contact)

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;addiction;Address;Adverse event;authority;Behavior;Behavioral;Benefits and Risks;benzo(a)pyrene-DNA adduct;Biological Markers;Blood Pressure;Carbon Monoxide;carcinogenicity;Categories;Characteristics;Cigarette;cigarette addiction;cigarette smoking;Clinical Trials;cohort;Collaborations;Consumption;Cotinine;Data;design;Development;diaries;disorder risk;DNA Adducts;DNA Damage;Doctor of Medicine;Dose;Double-Blind Method;double-blind placebo controlled trial;Electronic cigarette;Exhalation;Exposure to;Fiber;follow-up;Future;Genus Mentha;Health;Heart Rate;Infrastructure;innovation;Intention;interest;Isoprostanes;Marketing;Measures;Methodology;Methods;Modeling;Monitor;Nicotine;Nicotine Dependence;nicotine use;Nitrosamines;novel;Oral;Oral cavity;Oral health;oral irritation;Oxidative Stress;Participant;Phase;Placebo Control;Powder dose form;product development;Public Health;pulmonary symptom;Randomized;randomized placebo controlled trial;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research Personnel;Research Priority;response;Risk;Sales;Sampling;Services;Severities;Site;Smokeless Tobacco;Smoker;Smoking;smoking cessation;standard measure;Standardization;Telephone;Texas;Therapeutic;Tobacco;tobacco advertising;Tobacco Dependence;tobacco products;Tobacco use;tobacco user;tobacco-free;Toxic effect;Toxicant exposure;Universities;Urine;Virginia;Woman;Work

PROJECT_TITLE: Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers


PI_NAMEs: KRISHNAN-SARIN, SUCHITRA  (contact)

PROJECT_TERMS: addiction;addiction liability;Adult;Age;authority;Behavior;combustible tobacco;Conflict (Psychology);Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Equilibrium;Esthesia;Event;experience;experimental study;Exposure to;Flavoring;Harm Reduction;Human;improved;Inhalation;innovation;irritation;Isomerism;Knowledge;manufacture;Marketing;Menthol;Modeling;Mus;Nicotine;Nicotine Dependence;Nicotine Withdrawal;novel;Odors;Oral;Outcome;Perception;Physiological;Pilot Projects;pilot test;Plants;Public Health;Regulation;reinforcer;Reporting;Sarin;Sensory;sex;Sodium Chloride;Stereoisomer;Taste Perception;Tobacco;tobacco control;Tobacco Industry;Tobacco use;tobacco-free;Withdrawal

PROJECT_TITLE: Examining Appeal and Addiction Potential of Novel e-Cigarette Constituents


PROJECT_TERMS: addiction;Adverse event;Advertising;Animal Experimentation;authority;career;career development;Clinical Trials Data Monitoring Committees;Collaborations;college;Communication;Communities;community partners;data management;Development;Doctor of Philosophy;Electronics;Ensure;Environment;Ethics;expectation;experience;Faculty;Feedback;Funding;Funding Opportunities;Future;Goals;good laboratory practice;Government;Grant;Health;Health Sciences;Human Resources;human subject;Infrastructure;Institution;Laboratories;Laws;Leadership;Legal;Medicine;meetings;member;Mission;Monitor;Muscat;next generation;operation;Parents;Peer Review;Pharmacology;Pilot Projects;Policies;Positioning Attribute;Printing;Procedures;Productivity;professor;Psychiatry;Public Health;Quality Control;Recommendation;recruit;Reporting;Research;Research Personnel;Resource Allocation;Resources;response;Science;Scientist;Secure;Structure;success;symposium;timeline;Tobacco;tobacco control;tobacco products;tobacco regulatory science;Toxic effect;Training;Training Programs;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center;webinar;Work;working group

PROJECT_TITLE: Administrative Core


PI_NAMEs: FUCITO, LISA M (contact)

PROJECT_TERMS: addiction;Address;Adult;Area;authority;Behavior;Biological Markers;Carbon Monoxide;Cessation of life;Characteristics;Cigarette;cigarette addiction;cigarette smoke;cigarette smoking;Clinical Trials;combustible tobacco;Data;Dependence;design;Disease;Electronic cigarette;electronic cigarette use;Ethnic Origin;Formulation;Harm Reduction;improved;Individual;Intention;Interview;Lead;Marketing;Measures;Menthol;Mission;Modeling;Morbidity - disease rate;mortality;Nicotine;Nicotine Dependence;nicotine exposure;Oral;Participant;Patient Self-Report;Policies;population based;preference;primary outcome;Public Health;public health priorities;Race;Randomized;Randomized, Controlled Trials;Regulation;secondary outcome;sex;Sex Differences;Signal Transduction;Smoke;Smoking;smoking addiction;Smoking Behavior;smoking cessation;Sodium Chloride;Testing;Tobacco;tobacco advertising;tobacco control;tobacco flavor;tobacco products;tobacco regulatory science;Tobacco use;United States Food and Drug Administration;willingness

PROJECT_TITLE: Evaluationg the effects of e-cigarettes vs. oral nicotine pouches and product constituents (menthol flavor, nicotine concentration) on adult cigarette smoking and addiction


PI_NAMEs: HOBKIRK, ANDREA  (contact)

PROJECT_TERMS: addiction;Advisory Committees;Analytical Chemistry;Biological Markers;career;Collaborations;college;Complement;Disease;Education;Educational Curriculum;experience;Faculty;Fostering;Funding;Goals;Health;Individual;Infrastructure;innovation;Institution;Knowledge;Laboratories;Leadership;Legal;manufacture;Medical Students;Medicine;Mentors;Mentorship;Methods;multidisciplinary;next generation;peer coaching;Pilot Projects;Policies;Postdoctoral Fellow;pre-doctoral;programs;recruit;Regulation;Research;Research Personnel;Research Training;Resources;Scholars Program;Science;Site;skills;Students;Talents;Tobacco;tobacco advertising;Tobacco Dependence;tobacco products;tobacco regulatory science;Toxic effect;Training;Training and Education;training opportunity;Training Programs;Training Support;translational impact;undergraduate student;United States National Institutes of Health


PI_NAMEs: SUN, DONGXIAO  (contact)

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;8-hydroxy-2'-deoxyguanosine;Acetylcysteine;addiction;Aerosols;Analytical Chemistry;analytical method;Animals;Archives;Benzo(a)pyrene;Biological;Biological Markers;biological specimen archives;Blood;carcinogenicity;career;Cells;Characteristics;chemical property;Chemicals;Clinical;Clinical Chemistry;clinical investigation;Clinical Research;Collaborations;Collection;Communities;Data Analyses;design;Development;Disease;DNA Adducts;Educational Activities;Educational process of instructing;Electronic cigarette;electronic liquid;Emerging Tobacco Products;Exhalation;Glutathione;High Pressure Liquid Chromatography;Human;Human Resources;IL6 gene;Inflammation;instrumentation;investigator training;Isoprostanes;Laboratories;Laboratory Animal Models;Length;Maintenance;Mass Fragmentography;Measurement;Measures;Mentorship;method development;Methodology;Methods;Mission;Modeling;Nicotine;novel;Oral mucous membrane structure;Organic Chemistry;Oxidation-Reduction;Pattern;Phospholipids;Physical assessment;Physical condensation;physical property;Pilot Projects;Play;Postdoctoral Fellow;Preparation;Protocols documentation;Research;Research Design;Research Personnel;Research Support;Resources;Role;Saliva;Sampling;Science;Smoke;Smoking;Stable Isotope Labeling;Standardization;Techniques;Time;TNF gene;Tobacco;tobacco products;tobacco regulatory science;Tobacco smoke;Tobacco use;tobacco user;Toxic effect;Training;Urine;vaping;ventilation;Weight;Work

PROJECT_TITLE: Biomarker and Analytical Chemistry Core


PROJECT_TERMS: addiction;Address;Adherence;Advertising;Age;Annual Reports;Budgets;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community advisory board;Consultations;Data;Data Analyses;Data Collection;data integrity;data management;Data Set;data sharing;design;Eligibility Determination;Ensure;Ethnic Origin;IACUC;innovation;Institutional Review Boards;Interdisciplinary Study;Medical;member;Monitor;National Institute of Drug Abuse;Nicotine;Organizational Affiliation;Participant;participant retention;Patient Recruitments;Population;Press Releases;Productivity;Protocols documentation;Public Health;Publications;Quality Control;Race;recruit;Regulation;Reporting;Research;Research Personnel;Research Training;Resolution;Resources;Role;Running;Safety;Sarin;Schools;Science;screening;Services;sex;Source;Structure;success;syntax;Tobacco;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;United States National Institutes of Health


PI_NAMEs: LIAO, JIANGANG  (contact)

PROJECT_TERMS: Accreditation;addiction;Adopted;base;Bioinformatics;Biological Markers;Biometry;Biostatistics Core;career;career development;Characteristics;Clinical;Clinical Sciences;clinical translation;Clinical Trials;Collaborations;Communication;Communities;complex data;Computer software;course development;Data;Data Analyses;Data Collection;Data Coordinating Center;data integrity;data management;Data Reporting;data sharing;database design;Database Management Systems;Databases;design;electronic data;Enrollment;Ensure;Environment;experience;Experimental Designs;Funding;Future;Goals;Health;Health Sciences;Human;Human Resources;improved;Individual;Infrastructure;innovation;Institution;Instruction;instructor;Laboratories;lectures;Manuscripts;Measurement;meetings;member;Methodology;Monitor;Monitoring Clinical Trials;operation;Pilot Projects;Policies;population based;Preparation;Progress Reports;Public Health;Publications;Reporting;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Resources;Running;Safety;Science;Security;Services;skills;Statistical Data Interpretation;Statistical Methods;student mentoring;symposium;System;Techniques;Technology;Testing;Tobacco;tobacco products;tobacco regulation;Toxic effect;Training;Training Programs;United States National Institutes of Health;Update;Walking;web app;Work

PROJECT_TITLE: Biostatistics and Data Management Core


PI_NAMEs: O'MALLEY, STEPHANIE S (contact)

PROJECT_TERMS: addiction;Address;Area;authority;Awareness;career;Career Mobility;Collaborations;Core Grant;Dedications;Development;Ensure;Evaluation;evidence base;experience;Faculty;Fostering;Funding;Goals;Grant;innovation;interdisciplinary collaboration;Knowledge;Laboratories;Learning;Measurement;meetings;Mentors;Methods;multidisciplinary;next generation;Nicotine;novel;Pilot Projects;Postdoctoral Fellow;programs;Public Health;Publications;Regulation;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;skills;symposium;Time;tobacco control;tobacco products;tobacco regulation;tobacco regulatory science;Tobacco use;Training;training opportunity;Training Programs;Travel;Visit;Wages


PI_NAMEs: EID, TORE  (contact)

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol;Acetals;addiction;Animals;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;Chemicals;Collaborations;Consultations;cost;Cotinine;Custom;Data;data sharing;Databases;design;Dose;electronic liquid;enantiomer;Equipment;experience;Experimental Designs;Exposure to;Feedback;Flavoring;flexibility;Goals;Human Resources;interest;Knowledge;Laboratories;Marketing;Measures;Menthol;menthol glucuronide;Methodology;Nicotine;Nicotine Dependence;novel;Outcome;Outcome Study;Participant;Pilot Projects;Productivity;Publications;Quality Control;Reaction;reduce tobacco use;repository;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Rest;Risk;Sampling;Sampling Studies;Services;Site;Source;success;Sweetening Agents;Technology;Time;Tobacco Dependence;tobacco products;Tobacco use;Toxic effect;Toxicology;vapor

PROJECT_TITLE: Laboratory Core


PI_NAMEs: MOREAN, MEGHAN E (contact)

PROJECT_TERMS: addiction;Address;Adopted;Behavior;career;Clinical Trials;Collaborations;Complex;complex data;Consultations;Data;Data Analyses;data quality;Data Set;data visualization;Dependence;Development;Electronic cigarette;Electronic Nicotine Delivery Systems;Ensure;Eugenia;experimental study;Faculty;Failure;Foundations;Generations;Human;improved;innovation;Knowledge;laboratory experiment;Legal;Link;Measurement;Measures;member;Methodology;Methods;Modeling;Nicotine;Nicotine Dependence;novel;Observational Study;Patient Self-Report;Pattern;PhenX Toolkit;Pilot Projects;Population Assessment of Tobacco and Health;Procedures;Productivity;Psychometrics;Public Health;Publications;Qualitative Research;Reproducibility;Research;Research Design;Research Methodology;Science;Scientific Inquiry;Scientist;Self-Examination;Severities;skills;sound;Source;Statistical Data Interpretation;Statistical Methods;Statistical Models;statistics;success;Survey Methodology;Surveys;Testing;Tobacco;Tobacco Industry;tobacco products;tobacco regulatory science;Tobacco use;tool;Training;training opportunity;Translating;United States National Institutes of Health;Validation;Visualization;weapons;web site;webinar;Withdrawal

PROJECT_TITLE: Measurement and Analytics Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Lung cancer is the leading cause of cancer death and results from interplay of environmental and genetic risk factors. This project seeks to use very large data sources to interrogate joint effects of environment and genetics that increase cancer risks for individuals to inform risk reduction and recruitment to and management of low dose spiral CT screening.

PI_NAMEs: AMOS, CHRISTOPHER I. (contact)

PROJECT_TERMS: Adopted;African ancestry;Asian ancestry;behavior change;Behavior Therapy;Behavioral;Bioinformatics;Biological Markers;Biology;Biometry;Cancer Etiology;Cancer Patient;cancer prevention;cancer risk;causal variant;Cessation of life;Characteristics;Child;Clinical;cohort;Collection;Communities;computed tomography screening;Data;Data Sources;Development;Disease;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;ethnic minority;Ethnic Origin;Etiology;European;evidence base;Feedback;Foundations;Genes;Genetic;genetic analysis;genetic approach;genetic architecture;Genetic Polymorphism;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Germ Lines;Goals;Health Personnel;high risk;Hispanic ancestry;Human;improved;Individual;innovation;instrument;interest;Joints;low-dose spiral CT;lung cancer screening;Malignant neoplasm of lung;member;Mendelian randomization;Methodology;Methods;minority communities;Minority Groups;Modeling;Molecular;motivated behavior;multi-ethnic;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;never smoker;novel;Patients;Play;polygenic risk score;Polygenic Traits;Population;Population Heterogeneity;posters;Predisposition;programs;protein biomarkers;racial minority;recruit;Research;Resources;Risk;Risk Estimate;Risk Management;risk prediction;Risk Reduction;Role;Scoring Method;screening;screening program;Serum Proteins;Smoking;Smoking Behavior;social culture;Susceptibility Gene;Testing;therapy development;Time;tool;Trans-Omics for Precision Medicine;Translating;translational applications;Translations;uptake;whole genome

PROJECT_TITLE: Project 1: Smoking, environmental and genomic factors in lung cancer and managing risk


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Genetics;Neurosciences;Nutrition

ORG_CITY: HONOLULU

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Stereotypic repetitive behaviors that are generally believed to be nonfunctional, are seen in a wide range of vertebrate species in blood glucose-inducing, stress-associated environments, and are reduced under ketosis-related nutritional conditions. Accordingly, this research program has two goals: the short-term goal is to address the genes and their gene co-expression networks associated with repetitive behaviors in an experimental fish model implementing naturalistic heterogeneity in the genome and behaviors. The long- term goal is to reveal the genetic and neural mechanisms of how repetitive behavior is chosen among other voluntary behavior types, particularly in terms of stress-associated and nutritional conditions.

PI_NAMEs: IWASHITA, MOTOKO ;YOSHIZAWA, MASATO  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Algorithmic Analysis;Algorithms;Animal Genetics;Animal Model;Animals;Behavior;behavior prediction;Behavioral;Biological Models;Blood Glucose;Brain;Carbohydrates;Chronic stress;Complex;Corpus striatum structure;CRISPR/Cas technology;Data;Data Analyses;Data Set;Development;Dietary Intervention;dimension reduction;Disease;disease model;distraction;effective therapy;Environment;Environmental Impact;Exhibits;Experimental Models;Exposure to;Fishes;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Variation;Genome;Genomics;Goals;Heterogeneity;Human;Immediate-Early Genes;Inbred Mouse;individual variation;innovation;insight;Involuntary Movements;ketogenic diet;Ketone Bodies;Ketosis;Knowledge;Mammals;Maps;mating behavior;Mental disorders;Metabolic;metabolomics;Methods;Mexican;model organism;Modeling;Modernization;Molecular;Morphology;multidimensional data;Mus;Nervous System Physiology;neural;Neural Pathways;neuromechanism;Neurons;null mutation;nutrition;Nutritional;open data;Output;Pathway interactions;Patients;Periodicity;Physiological;Population;Population Heterogeneity;programs;Property;Quantitative Trait Loci;Recording of previous events;Reducing diet;repetitive behavior;Research;response;Sensory;Serum;Signal Transduction;Social Behavior;social learning;Standard Model;Stereotyping;Stress;success;Surface;System;Techniques;Technology;teleost fish;Testing;transcriptome;transcriptomics;Variant;Visualization;Wild Animals

PROJECT_TITLE: Gene Coexpression Network Regulating Repetitive Behavior under Nutritional Change.

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Precision Medicine;Prevention

PHR: Project 2: Integrating Biomarkers into Lung Cancer Risk Profiling Narrative Many lung cancers occur in individuals who are not eligible for screening with low-dose computed tomography (LDCT). The INTEGRAL-AT Project 2 will improve LDCT screening eligibility criteria by incorporating biomarkers in risk assessment and evaluating the user acceptability in a community-based screening program. We will also identify novel biomarkers for lung cancer in never smokers.

PI_NAMEs: JOHANSSON, MATTIAS ALEXANDER (contact)

PROJECT_TERMS: Address;Age;Bioinformatics;Biological Markers;biomarker panel;biomarker performance;Biometry;Blood specimen;blood-based biomarker;cancer biomarkers;Cancer Detection;Cancer Etiology;cancer genetics;cancer risk;case control;Cessation of life;clinical implementation;cohort;Communities;computed tomography screening;curative treatments;Data;Diagnosis;Diagnostic;early detection biomarkers;Early Diagnosis;Eligibility Determination;Etiology;Exclusion;Family history of;General Population;Genotype;Harm Reduction;Healthcare Systems;high risk;improved;Individual;innovation;Kentucky;low dose computed tomography;Lung;lung basal segment;lung cancer screening;Malignant neoplasm of lung;Measurement;Measures;Modality;Modeling;mortality;never smoker;never smoking;novel;novel marker;Occupational Exposure;Participant;Patients;Performance;Persons;polygenic risk score;predictive modeling;predictive tools;prevent;programs;Prospective cohort;protein biomarkers;Proteins;Proteomics;psychosocial;Public Health;Recording of previous events;recruit;Research;Risk;Risk Assessment;Risk Factors;Risk Marker;risk prediction model;Sampling;screening;screening program;Smoke;Smoking;smoking exposure;Smoking History;Smoking Status;Symptoms;Technology;Test Result;Testing;Time;Training;Translating;Translational Research;United States Preventative Services Task Force;Update;Validation;Work


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Nutrition

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE This project seeks to understand the role of serum advanced glycation end-products in the high frequency of tendon injury and impaired function in millions of Americans with diabetes. This critical project will use genetic mouse models and the study of people with diabetes to delineate the role of serum advanced glycation end- products in tendon injury and impaired function. With a long-term goal of developing new prevention and treatment strategies, this research will identify novel serum factors that drive tendon injury and impaired tendon function in the growing number of individuals with diabetes.

PI_NAMEs: CARROLL, CHAD CLAYTON (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;Advanced Glycosylation End Products;Affect;American;Automobile Driving;Biomechanics;Blood Glucose;Bovine Serum Albumin;Cell Culture Techniques;Cell Survival;Cells;Chronic;Clinical;Collagen;Collagen Fiber;Collagen Fibril;Complications of Diabetes Mellitus;Critical Pathways;crosslink;Data;db/db mouse;Deterioration;Development;Diabetes Mellitus;diabetic;Diabetic mouse;dimer;Economic Burden;Economic Conditions;Environment;Etiology;Extracellular Matrix;Extracellular Matrix Degradation;Food;Frequencies;Genes;Genetic;glycolaldehyde;Glycosylated hemoglobin A;Goals;Health;Homeostasis;Human;human subject;Hyperglycemia;imaging modality;Impairment;improved;in vivo;Individual;Inflammation;inhibitor;Injury;Intake;Interdisciplinary Study;Kidney;Knock-out;Knowledge;loss of function;Magnetic Resonance Imaging;Maintenance;Mechanics;Mediating;Mediator;Methodology;Mission;Mobility decline;Modeling;Modification;Modulus;Morphology;mouse model;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Diabetes and Digestive and Kidney Diseases;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Oxidative Stress;Pathology;Patients;Persons;Phenotype;Play;prevent;Prevention strategy;Process;Property;Quality of life;Receptor Activation;receptor for advanced glycation endproducts;Research;Risk;Rodent;Role;Serum;Shapes;Signal Transduction;social;Societies;Study of serum;tendon development;Tendon Injuries;Tendon structure;Testing;Therapeutic;treatment strategy;ultrasound;western diet;Work

PROJECT_TITLE: Role of serum advanced glycation end-products in altering tendon properties with diabetes

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PHR: Project Narrative Lung cancer continues to be the most common cancer and the leading cause of cancer death worldwide, and the reduction of lung cancer death remains to be a global priority. While low- dose computed tomography (LDCT) can reduce lung cancer mortality by 20-30%, there are emerging challenges including how to optimize screening intervals, address issues of racial disparity, and possible overdiagnosis. To maximize the benefit-harm ratio, our project aims to optimize biomarker-informed screening pathway while focusing on under-represented populations such as African Americans and Asian never smokers.

PI_NAMEs: HUNG, RAYJEAN J. (contact)

PROJECT_TERMS: Academic Medical Centers;Accounting;Address;Adherence;African American population;Asia;Asian;Asian population;Benign;Biological Assay;Biological Markers;biomarker panel;biomarker validation;Calibration;Canada;cancer diagnosis;Cancer Etiology;cancer risk;case control;Cessation of life;circulating biomarkers;Classification;Clinical Data;cohort;Collaborations;Communities;community engagement;computed tomography screening;Data;Data Element;data resource;design;Diagnosis;Diagnostic;Early Diagnosis;epidemiologic data;Epidemiology;ethnic diversity;Europe;feature selection;Focus Groups;Frequencies;Genetic;Genomics;Goals;high risk;Image;improved;Individual;International;Lead;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Machine Learning;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Minority Groups;model building;Modeling;Molecular;mortality;multiple omics;never smoker;Nodule;North America;Ontario;Participant;Pathway interactions;Patients;Population Heterogeneity;Positioning Attribute;predictive marker;Probability;prognostic value;programs;prospective;protein biomarkers;Proteins;public health priorities;Race;racial disparity;radiomics;Research;Research Personnel;Resources;Risk;Risk Management;Risk Reduction Behavior;Role;Sampling;screening;screening program;sex;Site;smoking exposure;Smoking Status;Spirometry;Taiwan;Translating;Translations;Underrepresented Populations;United Kingdom;United States Preventative Services Task Force;Universities;uptake;Validation;Visit;Washington;Work

PROJECT_TITLE: Translating Molecular and Clinical Data to Biomarker-Informed Screening Pathway


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: DALLAS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative The proposed project will provide empirical data that directly speaks to the factors impacting the long-term psychosocial functioning of transgender and gender diverse (TGD) youth receiving gender-affirming hormone therapy (GAHT; puberty suppression, testosterone, estrogen), which is urgently needed to guide sweeping international shifts already occurring in youth’s ability to access this treatment. The proposed project will also help illuminate the bidirectional relationships between youth and parent functioning and as well as the impact of the escalating sociopolitical stress faced by TGD youth and their parents. In addition to providing policy level guidance, this information will strengthen healthcare providers’ ability to anticipate the needs of diverse TGD youth and families and individualize the care they provide.

PI_NAMEs: KUPER, LAURA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescence;Adult;Age;Automobile Driving;barrier to care;Caring;Characteristics;Child;Climate;cohort;Collaborations;community based participatory approach;Critiques;Data;demographics;Development;Distress;Enrollment;Estrogens;experience;Family;follow-up;Gender;gender affirming care;gender affirming hormone therapy;gender diverse;gender dysphoria;gender minority stress;Growth;Health Personnel;Health Services Accessibility;improved;Individual;International;Knowledge;Literature;Location;Long-Term Effects;Longitudinal Studies;Measurement;Measures;Mental Health;Methods;Minor;minority stress;Movement;multidisciplinary;neglect;Outcome;parental influence;parental role;Parents;Pattern;personalized approach;personalized care;Persons;Play;Policies;policy recommendation;Politics;Process;programs;protective factors;Provider;psychosocial;psychosocial outcome;Puberty;puberty blocker;Quality of life;Regrets;Reporting;Research;resilience;resilience factor;Risk;Running;Sample Size;Social support;Statutes and Laws;Stress;stress state;stressor;Subgroup;Testosterone;Time;transgender;trend;United States;Victimization;Youth

PROJECT_TITLE: Long-term trajectories of psychosocial functioning among transgender youth and their parents.

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dissemination and Implementation Research;Genetics;Human Genome;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

PHR: Project Narrative The administrative core ensures that data and processes needed to support all needs for the Integrative Analysis of Lung Cancer Risk and Etiology – Application and Translation program project are met. The administrative core also supports early stages of implementation science to translate findings from discovery science to communities at risk for lung cancer development.

PROJECT_TERMS: Academic Medical Centers;Acceleration;Advisory Committees;African American population;Area;authority;Basic Science;Biological Markers;Cancer Etiology;Cancer Patient;cancer risk;cohort;Communication;Communities;Consultations;Data;data exchange;data harmonization;database of Genotypes and Phenotypes;Databases;Development;Discipline;Dissemination and Implementation;Documentation;Ensure;Environmental Risk Factor;Epidemiology;epidemiology study;Evaluation;financial relationship;Focus Groups;Foundations;future implementation;Genetic;Genetic study;Genetic Variation;genome wide association study;Genomics;Goals;Guidelines;implementation science;improved;Individual;interdisciplinary approach;International;Leadership;lung carcinogenesis;Maintenance;Malignant neoplasm of lung;meetings;Minority Groups;multidisciplinary;Nicotine Dependence;novel;novel strategies;Occupational activity of managing finances;Play;Population Heterogeneity;Predisposition;Procedures;Process;programs;protocol development;Qualitative Research;Regulation;Research;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;Role;Science;screening;screening program;Series;Site;Smoking;Smoking Behavior;Teleconferences;Time Management;tobacco carcinogenesis;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;Washington;web site;webinar


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE This project aims to work with patients and clinical care team members to co-design and implement strategies to increase use of home blood pressure monitoring in culturally diverse and low-income patient populations. We will conduct a trial of patient-focused and clinical-focused implementation strategies and assess the impact on blood pressure control. We will assess the costs of these strategies and how effective they were at safely and equitably increasing home blood pressure monitoring.

PI_NAMEs: KHOONG, ELAINE  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Implementation Strategies for Self-Measured Blood Pressure Monitoring in Racially and Ethnically Diverse Populations (InS2PiRED).


ADMINISTERING_IC: MD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative A pharmacogenomics-guided drug policy includes the genomic profile of an individual’s drug response with other clinical characteristics and may improve the safety and effectiveness of drug therapy. In some instances, however, pharmacogenomics-guided drug policy may improve the health for some patients, while leaving out patients from demographics that already suffer from health inequalities. This project will elucidate clinical value with a racial fairness lens without yet implementing a new pharmacogenomics-guided drug policy.

PI_NAMEs: TAYLOR, CASEY OVERBY (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: 3-Dimensional;Adoption;Age;All of Us Research Program;Blood Platelets;Body Weight;Case Study;Characteristics;Clinical;comorbidity;CYP2C19 gene;Data;data access;Decision Making;demographics;Detection;Dose;Effectiveness;Electronic Health Record;Eligibility Determination;European ancestry;Future;Genetic Markers;Genetic Variation;genome sequencing;genomic profiles;Genotype;Guidelines;Health;health disparity;health inequalities;Healthcare Systems;improved;Individual;insight;interest;lens;Measures;Medical center;Modeling;observational cohort study;Outcome;outcome disparities;parity;Participant;Patients;Performance;Persons;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Pharmacy and Therapeutics Committee;Phenotype;Policies;Population;Process;Publishing;Race;racial bias;racial diversity;racial population;Regimen;Research;response;risk mitigation;Safety;Selective Serotonin Reuptake Inhibitor;Services;structural determinants;Structure;Testing;thiopurine;Time;TPMT gene;Translating;United States;whole genome;Work

PROJECT_TITLE: Real-World Data Estimates of Racial Fairness with Pharmacogenomics-Guided Drug Policy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention

PI_NAMEs: AMOS, CHRISTOPHER I. (contact);HUNG, RAYJEAN J.;JOHANSSON, MATTIAS ALEXANDER;LIN, XIHONG

PROJECT_TERMS: Address;Bioinformatics;Biometry;Cancer Etiology;cancer risk;Collaborations;college;Computer software;Computing Methodologies;Data;Data Analyses;Data Collection;data management;Data Science;data sharing;design;Ensure;Environment;Epidemiology;epidemiology study;experience;Faculty;Genetic;genome sequencing;genome wide association study;Genomics;Goals;Informatics;interest;Leadership;machine learning method;Malignant neoplasm of lung;Mediation;Medicine;member;Mendelian randomization;Methodology;Methods;Mission;multi-ethnic;novel;Play;polygenic risk score;Population;Population Sciences;Postdoctoral Fellow;programs;Public Health Schools;rare variant;Research;Research Design;Research Methodology;Research Personnel;Resources;risk prediction;statistical and machine learning;Statistical Methods;student training;Students;tool;Training Programs;Variant;whole genome;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PORTLAND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Smoking is associated with increased wound healing time, wound infections, and cardiovascular complications among surgery patients, leading to the implementation of policies requiring smoking cessation prior to elective surgery. These policies provide an opportunity for health care providers to assist patients in achieving both short-and long-term smoking cessation; however, the impact of these policies on socioeconomically disadvantaged patients, a population that experiences significant smoking-related disparities, has not been evaluated. Our mixed methods study fills this important gap by examining the impact of a policy implemented in Oregon in 2017 that requires Medicaid-insured patients to quit smoking prior to elective surgery on smoking (smoking cessation assistance and cessation) and surgery-related (receipt of surgery, surgical complications) among patients seen in community health centers.

PI_NAMEs: BAILEY, STEFFANI R (contact);HUGUET, NATHALIE

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Abstinence;Address;Adoption;Adult;Arthroscopy;Cardiovascular system;care coordination;Cigarette;Data;design;Development;Disparity;Economically Deprived Population;Effectiveness;Electronic Health Record;Evaluation;experience;Goals;Guidelines;Health;Health Personnel;Healthcare;Healthcare Systems;Hospitals;improved;innovation;Insurance;interest;Interview;Knee;Knowledge;Lead;Link;low socioeconomic status;Medicaid;medically necessary care;Methods;National Institute on Minority Health and Health Disparities;Neighborhood Health Center;non-smoker;Operative Surgical Procedures;Oregon;Orthopedic Surgery;Orthopedics;Outcome;Patients;payment;Perception;Perioperative;Policies;Policy Maker;Population;Postoperative Period;primary care clinician;Privatization;programs;Protocols documentation;Quasi-experiment;Reduce health disparities;repaired;Reporting;Rotator Cuff;Smoking;smoking cessation;smoking prevalence;socioeconomic disadvantage;Structure;Surgeon;surgery outcome;Surgical complication;surgical disparities;Surveys;Time;United States;Visit;wound healing;Wound Infection

PROJECT_TITLE: ASSIST: Assessment of Medicaid policy on Smoking Cessation Assistance and Surgical Outcomes

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Arlington

ORG_NAME: ISA ASSOCIATES, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project aims to develop a mobile stress management program for hypertensive African American men to reduce racial and non-racial stress and improve blood pressure. Because most Black men have smartphones, this program can be easily distributed at a lower cost. For African American men, the skills contained in this program will help them reduce stress and the negative impact that stress has on blood pressure.

PI_NAMEs: LEAF, SAMANTHA L. (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Accounting;Address;Adherence;Affective;African American;African American population;Alcohol consumption;allostatic load;Anti-Hypertensive Agents;Attention;Behavior;Behavioral;Benchmarking;Biological;Black American;black men;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;Cardiovascular Diseases;cardiovascular risk factor;Cellular Phone;Chronic stress;Cognition;Cognitive;coping;Coping Behavior;Coping Skills;cost;cost effective;Counseling;design;Development;Diabetes Mellitus;Diagnosis;Diastolic blood pressure;Discrimination;Disparity;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Emotions;Ethnic Origin;Etiology;experience;Family;follow-up;Gender;Goals;group intervention;Guidelines;Health Benefit;health care settings;health disparity;HIV;Homicide;Hyperphagia;Hypertension;hypertension control;hypertensive;improved;Intervention;Knowledge;Learning;Libraries;Life Expectancy;life span;Life Style;Link;male;Marketing;Measures;Medical;medication compliance;men;Mental Health;mHealth;mindfulness;mindfulness meditation;modifiable risk;mortality;Motivation;Outcome;Participant;peer;Personal Satisfaction;Pharmaceutical Preparations;Phase;Physical activity;physical conditioning;Physiological;Positioning Attribute;programs;prototype;psychologic;Public Health;Race;racial discrimination;racial disparity;racial identity;Randomized;Reduce health disparities;Relaxation Techniques;remediation;Reporting;Research;Resources;response;Services;skills;Smoking;Source;Stress;stress management;stress reduction;stressor;Stroke;substance use;System;Techniques;Text Messaging;text messaging intervention;therapy design;Thinking;Training;Underserved Population;United States;Work

PROJECT_TITLE: Reducing Hypertension among African American Men: A Mobile Stress Management Intervention to Address Health Disparities


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DREXEL UNIVERSITY

PHR: NARRATIVE – OVERALL Climate change is a fundamental threat to health and health equity in cities. The Drexel Climate Change and Urban Health Research Center (CCUH) will support the research needed to understand what cities can do to protect the growing urban populations of the world from the adverse effects of climate change in ways that promote health and equity among the rapidly increasing number of urban residents.

PI_NAMEs: DIEZ ROUX, ANA VICTORIA (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Adverse effects;Americas;Brazil;California;Cities;climate adaptation;climate change;climate impact;climate-related health;Collaborations;Communities;community engaged research;community engagement;comparative;Country;data infrastructure;Development;Educational workshop;Environment;Equity;Funding;Future;Generations;Goals;Grant;Growth;Guatemala;Health;health equity;health inequalities;Health Policy;Health Promotion;Heterogeneity;Home;Income;Inequity;Infrastructure;innovation;Institution;institutional capacity;Intervention;Latin America;Latina;low and middle-income countries;migration;mortality;organizational structure;Policies;Policy Maker;Population;population health;Productivity;programs;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Site;social;Structure;Training Activity;Translating;Translations;Universities;urban area;Urban Community;Urban Health;Urban Population;urban setting;Urbanization;Work

PROJECT_TITLE: Drexel Climate Change and Urban Health Research Center (Drexel CCUH)


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Americas;Brazil;California;Central America;Cities;climate change;climate impact;climate-related health;Code;Collaborations;Communication;Community Actions;community engagement;Community of Practice;Country;Data;data infrastructure;data management;data repository;data warehouse;Development;diversity and inclusion;Ensure;Equity;Evaluation;experience;FAIR principles;Funding;Funding Opportunities;Future;Growth;Guatemala;Health;health equity;Infrastructure;Latina;Lead;member;Metadata;Methodology;Monitor;Natural experiment;nutrition;online repository;organizational structure;Output;Panama;Participant;Policies;Readability;Reporting;Research;Research Activity;Research Project Grants;Resources;Secure;Site;Structure;Translations;Universities;urban area;Urban Health;Work


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Networking and Information Technology R&D (NITRD);Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Telehealth

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Adolescents and young adults (AYAs) with sickle cell disease (SCD) are at high risk for disease complications, emergency room visits, and early mortality. These primarily Black AYA also face social determinants of health (SDOH)-related barriers which impede their disease self-management. We propose to evaluate an innovative self-management intervention (SCThrive) that combines telemedicine, peer support, and a mobile app to target individual and SDOH-related barriers to improve patient activation, self-management, and health outcomes.

PI_NAMEs: CROSBY, LORI E (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Acute;Acute Pain;Address;Adherence;Adolescence;Adolescent;Adolescent and Young Adult;Affect;Aftercare;Age;Behavior;Behavior Therapy;Black race;Caregivers;Caring;Childhood;chronic pain;Clinical;clinically significant;Collaborations;community advisory board;Community Healthcare;comorbidity;Companions;Complex;culturally appropriate intervention;Discrimination;Disease;Disease Management;Disease Progression;disorder risk;Eating;Education;efficacy evaluation;eHealth;Emergency department visit;Exercise;experience;Face;Family;Financial Hardship;follow-up;Foundations;functional disability;Genetic Diseases;good diet;Health;Health Care Costs;health care service utilization;health equity;health literacy;health related quality of life;Health Services Accessibility;Healthcare Systems;high risk;Hydration status;improved;Individual;infancy;innovation;Intervention;Intervention Studies;Knowledge;Life;Link;Magnetic Resonance Imaging;Methods;mHealth;mobile application;Modeling;Moods;mortality;multidisciplinary;Neurologic;novel;Organ;Outcome;Pain;Participant;Patients;peer support;Pharmaceutical Preparations;prevent;Prevention;Preventive screening;primary outcome;Race;Randomized;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;Reporting;Research;Retinal Diseases;Risk;secondary outcome;Self Efficacy;Self Management;Sickle Cell Anemia;Site;skills;social;social health determinants;social stigma;Social support;standard care;standard of care;Statistical Data Interpretation;Strategic Planning;stress management;Symptoms;Telemedicine;Time;Transportation;treatment comparison;treatment group;treatment response;United States;virtual group;Work;young adult;Youth

PROJECT_TITLE: A socio-ecological approach for improving self-management in adolescents with SCD

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Bioengineering;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHESHIRE

ORG_NAME: RECOMBINANT TECHNOLOGIES, LLC

PHR: Alzheimer’s Disease (AD) is a common disease leading to dementia affecting millions of people worldwide. Amyloid has been implicated as one of the initiating factors in Alzheimer’s. Therefore, it is a target in the treatment of AD. Unfortunately, treatment options to date are limited or have limited effects. Recombinant Technologies (RT) owns a patent on an active pharmacological ingredient (API) with demonstrated proof of concept in a clinically relevant mouse model for AD. Incorporating the same API, RT has designed and developed an extra-corporeal device, namely, Amytrapper catheter to capture circulating amyloid. The device works similar to hemodialysis equipment that removes urea in patients with kidney failure. RT now plans to perform additional research and development to optimize and fine- tune the device, demonstrate proof of concept in blood samples from AD patients, obtain an investigative device exemption (IDE) classification from FDA and get ready for a first in human pilot study. The proposed innovative device may lead to achieving a novel treatment strategy that improves the lives of patients with AD.

PI_NAMEs: SUNDARAM, PAZHANI  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: abeta accumulation;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Animals;Antibodies;Award;Behavioral;Binding;Biotechnology;Biotinylation;Blood;Blood Component Removal;Blood specimen;Brain;Breakthrough device;Canis familiaris;Capital;Catheters;Cause of Death;Characteristics;Chicago;Circulation;Classification;Clinical;clinically relevant;Cognition;Cognitive;commercialization;Complement;Connecticut;Coupled;Dementia;design;Devices;Dialysis procedure;Disease;Equilibrium;Equipment;ethylene glycol;Evaluation;Excision;experience;extracellular;FDA approved;Feedback;first-in-human;Funding;Generations;Goals;Hemodialysis;Human;human study;Immunologics;improved;In Vitro;in vivo;in vivo evaluation;Incidence;Injections;innovation;Investments;Kidney Failure;Knowledge;Legal patent;Liquid substance;Market Research;Marketing;Medical;Medical Device;Memory;Modeling;Monoclonal Antibodies;mouse model;Mus;Names;novel;Patients;Peptide Initiation Factors;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Physiological;Pilot Projects;Plasma;Play;pre-clinical;prevent;Privatization;programs;prototype;Rattus;Recombinants;Regimen;Regulation;Reporting;Research;research and development;Retro-Inverso Peptide;Role;Safety;Saline;Sampling;scale up;side effect;skills;Small Business Innovation Research Grant;success;Technology;Testing;Tg2576;Therapeutic;Time;timeline;Toxicology;treatment strategy;Urea;Whole Blood;Work

PROJECT_TITLE: Novel Extracorporeal Device 'Amytrapper' To Remove Beta Amyloid In Alzheimer'sDisease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BILAL, USAMA  (contact)

PROJECT_TERMS: Age;aging population;Americas;Area;Automobile Driving;Biometry;Brazil;built environment;Cessation of life;Characteristics;Child;Cities;climate adaptation;climate change;climate impact;climate-related health;Collaborations;community engagement;comparative;Country;Crowding;Data;data infrastructure;Development;Disease;Disparity;Economics;Education;Environment;Equity;ethnic minority;Ethnic Origin;Etiology;Event;Exposure to;extreme heat;extreme temperature;Frequencies;Future;Gender;Goals;Green space;Guatemala;Health;Health Disparities Research;health disparity;health equity;health inequalities;heat island;Heterogeneity;high risk;high risk population;Household;improved;Individual;Inequality;Inequity;interest;Latin America;Latina;low socioeconomic status;Measurement;method development;Modification;mortality;neighborhood association;Neighborhoods;novel strategies;older adult;outcome disparities;Panama;Pattern;Philadelphia;Policies;Policy Maker;Population Density;Predisposition;Race;racial minority;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Project Summaries;residential segregation;Resources;segregation;social;Social Environment;statistics;Subgroup;Temperature;Training;Translations;Universities;Urban Developments;Urban Health;urban planning;Urban Population;Urbanization;Variant;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Research Project Core


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Intersectional stigmas due to black race, same-sex attraction/behavior, and presumed HIV-positive status threaten the HIV prevention uptake and well-being of Black men who have sex with men (BMSM). Building resilience to intersectional stigmas is critical for BMSM to mitigate psychological distress and enhance engagement in the HIV prevention continuum. The proposed project seeks to (1) define the nuanced resiliency mechanisms in countering intersectional stigmas at multiple socioecological levels; (2) develop and validate the first multidimensional stigma-resilience measure tailored for research conducted with BMSM.

PI_NAMEs: LIU, YU  (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adult;AIDS prevention;Anxiety;Area;Behavior;black men who have sex with men;Black race;cognitive interview;Collaborations;Communities;community engagement process;Community Healthcare;County;design;Dimensions;Discrimination;Disparity;Environment;experience;Face;Funding;Future;Gays;Goals;health disparity;health disparity populations;Health Personnel;Healthcare;Hispanic;HIV;HIV diagnosis;HIV Seronegativity;HIV Seropositivity;Homophobia;Homosexuality;Human immunodeficiency virus test;improved;Individual;insight;Institution;intersectionality;Intervention;Interview;Latino;Maps;marginalized population;Measurement;Measures;Mediator;medical schools;men who have sex with men;Mental Depression;Methodology;Minority;Modeling;National Institute on Minority Health and Health Disparities;Neighborhoods;novel;Outcome;peer;Personal Satisfaction;Population;pre-exposure prophylaxis;Prevention strategy;Process;programs;promote resilience;psychologic;psychological distress;Psychometrics;Race;racism;Research;resilience;resilience factor;resilience scale;response;Same-sex;Sexuality;social stigma;Stigmatization;Strategic Planning;Stress;Subgroup;Tennessee;Testing;testing uptake;theories;transgender women;United States National Institutes of Health;Universities;uptake;Variant;Violence;women of color;Work

PROJECT_TITLE: Developing and Testing a Novel Multidimensional Stigma-Resilience Measure for Stigma Reduction Research with Black Men Who Have Sex with Men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Public Relevance Statement The proposed research tests the effectiveness of an adapted evidence-based intervention for Black girls and male caregivers. Using a framework that speaks to the development of Black girls acknowledging structural violence (stereotype messaging and lack of protection), the PI will test whether an adapted family-based intervention, IMARA for Black Male caregivers and Girls Empowerment (IMAGE), will improve the sexual and reproductive health of Black girls by engaging Black men in their protection. We will simultaneously identify the degree of implementation success and factors associated with success across five community-based organizations serving Black families and youth.

PI_NAMEs: CROOKS, NATASHA KAELLA (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: 18 year old;19 year old;2 arm randomized control trial;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adolescence;Adoption;AIDS prevention;arm;Attention;Attitude;Awareness;Belief;Black AIDS;black men;Black race;black women;Caregivers;Chicago;Communication;community organizations;comparison control;condoms;Consent;consistent condom use;Control Groups;Data;design;Development;Discrimination;Disparity;Educational Curriculum;Effectiveness;effectiveness testing;efficacy trial;emotion regulation;empowerment;Evidence based intervention;Evidence based program;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Family;Family Relationship;Female;Focus Groups;follow-up;future implementation;Gender;girls;Health Disparities Research;health outcome disparity;Health Promotion;HIV;HIV diagnosis;HIV/AIDS;Human Resources;implementation determinants;implementation efforts;implementation process;improved;Incidence;Individual;Infection;infection rate;infection risk;Infertility;innovation;Intervention;intervention delivery;intervention effect;Interview;Knowledge;Link;male;Mediation;men;Monitor;neglect;Outcome;Pelvic Inflammatory Disease;Phase;pilot test;prevent;Prevention program;primary outcome;Process;programs;protective effect;Public Health;Race;racial disparity;racial population;Randomized;Randomized, Controlled Trials;Reporting;Research;resilience;Resources;Risk;risk mitigation;Role;secondary outcome;sex;Sex Behavior;sexual and reproductive health;sexual debut;Sexual Health;Sexual Partners;sexual risk behavior;sexual violence;Sexually Transmitted Diseases;social culture;Socialization;Stereotyping;STI prevention;success;Surveys;Testing;theories;Time;United States;Violence;Woman;Youth

PROJECT_TITLE: A Family-Based HIV Prevention Program for Black Men to Protect Black Girls

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: The project describes a new mathematical data analysis approach, rooted on transport and related phenomena, which is aimed at greatly enhance our ability to extract meaning from diverse biomedical datasets, while augmenting the accuracy of predictions as compared to existing modeling tools such as deep learning. This period of the project focuses on generalizing our previous approach to virtually all data types in biomedical data sciences. We will explore proof of concept applications in cytometry, pathology, and radiomics.

PI_NAMEs: ROHDE, GUSTAVO KUNDE (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: absorption;Address;Biological;biomedical data science;Black Box;Brain imaging;breast cancer diagnosis;cancer risk;Cells;chemical reaction;Classification;Clinical Sciences;Collaborations;Communities;Complement;Complex;Computer Models;Computer software;COVID-19 patient;Cytometry;Data;Data Analyses;data mining;data modeling;Data Set;data space;deep learning;deep learning model;Development;Discipline;Documentation;electric impedance;Electronic Health Record;Energy consumption;Engineering;Ensure;experimental study;Funding;Future;Gene Expression;generative models;Genome;Goals;high dimensionality;Image;imaging Segmentation;Imaging technology;improved;innovation;Knee Osteoarthritis;Learning;lectures;Letters;machine learning model;Magnetic Resonance;Magnetic Resonance Imaging;mathematical model;Mathematics;Measurement;Measures;Methodology;Methods;microscopic imaging;Modeling;Molecular;morphometry;multidimensional data;neural network;Optics;Organ;Outcome;Pathology;Pattern;Pattern Recognition;Phase;predictive modeling;Problem Solving;radiological imaging;radiomics;reconstruction;Risk;Sampling;Scientist;Series;Signal Transduction;software development;Specific qualifier value;Speed;System;Techniques;Technology;technology research and development;tool;training data;tumor progression;virtual;Visualization;voltage

PROJECT_TITLE: Transport transforms for biomedical data modeling, estimation, and classification

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SANCHEZ, BRISA N (contact)

PROJECT_TERMS: Acceleration;Address;Anthropology;Applications Grants;Award;Biometry;Catalogs;Cities;climate change;climate impact;climate-related health;Collaborations;community engagement;Data;design;Development;Dimensions;Discipline;Economic Conditions;Educational Status;Educational workshop;Engineering;Environmental Health;epidemiology study;Equity;ethnic disparity;Ethnic Origin;Evaluation;experience;Feasibility Studies;Funding Opportunities;Future;Geography;Goals;Grant;Growth;Health;health equity;Health equity research;health inequalities;Health Sciences;Human Resources;Inequity;Infrastructure;innovation;institutional capacity;Journals;Knowledge;Latin American;Location;low and middle-income countries;Methodology;Methods;Natural experiment;novel;Pilot Projects;Policies;Postdoctoral Fellow;programs;promote resilience;Race;racial disparity;Recording of previous events;Research;research data dissemination;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Training;Role;Site;skills;social epidemiology;social health determinants;Social Sciences;socioeconomics;Structure;Students;System;tool;Training Activity;Translating;Translations;Underrepresented Populations;United States National Institutes of Health;urban area;Urban Health;urban planning;Variant;webinar;Work;working group

PROJECT_TITLE: Research Capacity Building Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: LAZO ELIZONDO, MARIANA  (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;Americas;Automobile Driving;Central America;Cities;Climate;climate adaptation;climate change;climate data;climate impact;Collaborations;Communities;Community Actions;community center;community engaged research;community engagement;Community Networks;community organizations;community setting;Country;Data;Decision Making;design;Development;digital;dissemination strategy;diversity and inclusion;Elements;Ensure;Equity;Ethnic Origin;expectation;experience;Faculty;Foundations;Funding;Future;Generations;Guatemala;Health;health data;health equity;health inequalities;Health Promotion;Home;Inequality;Institution;institutional capacity;interactive visualization;International;Interview;Latin America;Leadership;Learning;Measures;member;Monitor;multidisciplinary;nutrition;Outcome;Output;Panama;Performance;Persons;Play;Policies;Policy Developments;Policy Maker;Policy Making;population health;Race;Recommendation;Research;Research Personnel;Research Priority;Research Project Grants;scale up;Site;Socioeconomic Factors;Specialist;Strategic Planning;Surveys;System;timeline;translational engagement;Translations;Universities;urban area;Urban Health;Urbanization;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: We seek to determine how myosin V motors choose the correct organelle cargoes, and deposit them at their new destinations. Mutations in myosin V underlie diseases in the brain, skin pigmentation and the digestive tract. Thus, insights into myosin V regulation, may provide insights into how to treat some of these diseases.

PI_NAMEs: WEISMAN, LOIS S (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adopted;Animals;Architecture;Binding;Biochemical;Biochemistry;Brain;Cell Physiology;cell type;Cells;Complex;Cryoelectron Microscopy;Data;Dedications;Defect;Deposition;Destinations;Disease;Elements;Eukaryota;Exhibits;experimental study;Gastrointestinal tract structure;Genetic;genetic analysis;Genetic Screening;Human;insight;Kinesin;Knowledge;Label;Link;Lysosomes;Mass Spectrum Analysis;Messenger RNA;Microscopy;Microtubules;Molecular Conformation;Molecular Motors;Mothers;Motor;Movement;multicatalytic endopeptidase complex;mutant;Mutation;Myosin Type V;Neck;Organelles;Organism;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Play;Property;protein complex;protein degradation;Proteins;recruit;Regulation;Role;Saccharomyces cerevisiae;Scaffolding Protein;Site;Skin Pigmentation;System;Tail;Testing;Time;Tissues;ubiquitin-protein ligase;Vacuole;yeast genetics;Yeasts

PROJECT_TITLE: Regulation of myosin V interaction with cargo

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Nanotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE STATEMENT Our innovative experimental approach using nanopore sequencing provides an unparalleled opportunity to study complex epigenetics events at stem cell biology and germ cell biology. In addition, our sophisticated bioinformatics platform will provide a set of robust and handy tools to fully analyze nanopore sequencing epigenome data, such that this cutting-edge technology can be feasible in biomedical research laboratories of all sizes. The analysis of nanopore sequencing epigenome data can identify epigenetic events at each single long DNA molecules, providing a solid foundation for precision medicine.

PI_NAMEs: AU, KIN FAI  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Acceleration;Address;Affect;Alleles;analysis pipeline;base;Binding;Biochemical Reaction;Bioinformatics;Biological;Biological Process;Biomedical Research;bisulfite;Cell Proliferation;Cell Reprogramming;Cellular biology;Chromatin;chromatin immunoprecipitation;Collaborations;Complex;crosslink;Data;Data Analyses;data format;demethylation;Development;DNA;DNA biosynthesis;DNA Methylation;DNA Repair;DNA Transposable Elements;Embryonic Development;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;Event;experience;experimental study;Foundations;Genes;Genome;genome integrity;Genomic Imprinting;Genomic Segment;Germ Cells;Human;human embryonic stem cell;Human Genome;imprint;improved;Individual;innovation;Investigation;Laboratory Research;Length;Methodology;Methods;Methylation;Modification;Mus;Names;nanopore;next generation sequencing;Nucleosomes;Nucleotides;Pattern;Phase;precision medicine;Protocols documentation;prototype;public health relevance;Publications;Regulation;Repetitive Sequence;Research;Resolution;Role;Sampling;Scientist;Series;Signal Transduction;single molecule;Solid;stem cell biology;stem cells;Structure of primordial sex cell;technique development;Techniques;Technology;tool;transcription factor;Transcription Process;transcriptome;Universities;Work

PROJECT_TITLE: Experimental and bioinformatics platform for epigenome analysis using nanopore sequencing

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Services;Networking and Information Technology R&D (NITRD);Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SUFFOLK

ORG_NAME: NASONI LLC

PHR: The Phase II SBIR goal is to enhance, validate, and commercialize Access-H2O, a sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury. Spinal cord injury (SCI) severely impacts functional independence & ability to perform activities of daily living (ADLs) with those impacted above C8 having limited use of arms and hands for drinking, washing, and grooming. Therefore, commercialization of smart fountain faucets, to automatically deliver water in target temperature, force, & nozzle setting for a specific ADL have potential to empower individuals with SCI for greater independence & improved quality of life.

PI_NAMEs: JENG, HUEIWANG ANNA COOK;WADDELL, JOHN STEVEN (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: Activities of Daily Living;Adherence;Algorithms;Architecture;arm;Bathing;Calibration;Caregiver Burden;case control;Cervical spinal cord injury;Clinic;Clinical;Clinical Trials;commercialization;Computer software;cost;Data;data infrastructure;design;Devices;diagnostic algorithm;digital ecosystem;drinking;drinking water;Eating;Effectiveness;Employment;empowerment;Ensure;Environment;Eye;Face;field study;Foundations;Freedom;Functional impairment;functional independence;functional status;gaze;Goals;Grooming;Hand;Health care facility;Home;Household;Hydration status;Impairment;improved;Incidence;Individual;Injury;innovation;intelligent algorithm;Intuition;Learning;Life;Location;manufacture;manufacturing process;Maps;Marketing;Mental Health;Methods;mobile application;Morbidity - disease rate;mortality;novel;novel diagnostics;Performance;Persons;Phase;preference;Procedures;Production;prototype;Quadriplegia;Quality of life;reconstruction;Reporting;self esteem;sensor;Services;severe injury;Small Business Innovation Research Grant;Software Validation;Spinal cord injury;Sterile coverings;Stream;success;System;Systems Integration;Target Populations;Technology;Temperature;Testing;time use;Update;Upper Extremity;usability;Voice;Water

PROJECT_TITLE: Access-H20: Sensor driven smart faucet to enable and empower independent drinking and grooming for individuals impacted by spinal cord injury


ORG_CITY: SEATTLE

ORG_NAME: PHASE GENOMICS, INC.

ORG_STATE: WA

PHR: NARRATIVE For decades chromosomal aberrations have been useful biomarkers for mechanistic investigations of, diagnosis, and treatment decision making for liquid tumors. The utility of chromosomal aberration in diagnosis and stratification of solid tumor treatment options is limited by the fact that virtually all solid tumor samples are stored as formalin-fixed paraffin embedded (FFPE) tissue. In this proposal we describe a scalable proximity ligation sequencing method and analysis platform that can overcome limitations presented by the highly fragmented DNA found in FFPE tissue to identify chromosomal aberrations in solid tumors in FFPE blocks, enabling research and diagnostic applications.

PI_NAMEs: EACKER, STEPHEN MATTHEW (contact)

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: Address;Biological Markers;biomarker discovery;Biopsy;blood neoplasm;Cell Line;Cell Survival;Characteristics;Chromatin;Chromosome abnormality;chromosome conformation capture;Chromosomes;Clinical;clinically relevant;cohort;Commercial grade;Complex;computational platform;cost;Cytogenetic Analysis;Data;Data Set;Decision Making;design;Detection;Development;Diagnosis;Diagnostic;diagnostic biomarker;DNA;Formaldehyde;Formalin;Freezing;Funding;Future;genome analysis;Genomic DNA;Genomic Segment;Genomics;Goals;Grant;Hi-C;Hydration status;improved;Industrialization;informatics tool;insertion/deletion mutation;Investigation;Karyotype determination procedure;Letters;Libraries;Ligation;Liquid substance;Malignant Neoplasms;Maps;Methods;Modernization;Molecular Weight;Nature;next generation sequencing;novel strategies;Online Systems;Optics;Organic solvent product;Paraffin Embedding;Performance;Phase;pre-clinical;preservation;Process;prognostic;Prognostic Marker;Protocols documentation;Recovery;Reporting;Reproducibility;Research;Research Personnel;Resolution;Resources;Sampling;Services;Signal Transduction;Single Nucleotide Polymorphism;Small Business Innovation Research Grant;Solid Neoplasm;Specimen;Stratification;success;System;Technology;Testing;Time;Tissue Embedding;tumor;Validation;virtual

PROJECT_TITLE: Chromosomal aberration detection in FFPE tissue using proximity ligation sequencing


ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Project Narrative Membrane proteins are embedded in the complex lipid environment of the biological membrane. Membrane protein function is often regulated by specific lipid interactions and, therefore, the identification and characterization of protein-lipid interactions is of paramount biological importance. This proposal seeks to apply highly innovative and integrative approaches, combining numerous biophysical techniques, to identify and characterize protein-lipid interactions at the molecular level.

PI_NAMEs: BAKER, ERIN S;LAGANOWSKY, ARTHUR D (contact);MARTY, MICHAEL T;ZHOU, MING

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Affect;Affinity;Binding;Binding Sites;Biological;Biology;biophysical properties;biophysical techniques;Biophysics;Brain;Cardiolipins;Carrier Proteins;Cellular Membrane;Chemicals;cofactor;Complex;Complex Mixtures;Cryoelectron Microscopy;Data;density;Detergents;Development;Discipline;Environment;Event;Exhibits;Experimental Designs;Glean;Heart;Immobilization;Impairment;Individual;innovation;insight;Integral Membrane Protein;Ion Channel;Knowledge;Length;Lipid Binding;Lipid Chemistry;lipidomics;Lipids;Liposomes;Mass Spectrum Analysis;Measurement;medical specialties;member;Membrane;Membrane Lipids;Membrane Proteins;Membrane Structure and Function;method development;Methods;Molecular;Mutation;nanodisk;Natural Extract;novel;novel strategies;Outcome;Physiological;Physiology;pi bond;Positioning Attribute;preference;Protein Biochemistry;protein function;protein reconstitution;protein structure;Proteins;Protocols documentation;reconstitution;Research;Role;stereochemistry;stoichiometry;structural biology;Structure;Tail;Technology;Testing;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Understanding the role of lipids in structure and function of membrane proteins


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: Project Narrative Youth are increasingly living their lives filtered through social media account participation—a setting where marketers are constantly innovating to gain youth attention and influence. Effective e-cigarette control strategies for adolescents require a more comprehensive understanding of the potential impact of social media marketing on their attitudes and use. The current project will use state-of-the-art techniques to examine these questions and thereby increase the ability of public health officials and policymakers to develop appropriate countermeasures.

PI_NAMEs: HARRELL, PAUL TRUMAN (contact)

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: addiction;Adolescence;Adolescent;Algorithms;Attention;Attitude;Awareness;Behavior;Belief;cigarette smoking;Data;Data Analyses;Data Set;Development;development policy;Education;Electronic cigarette;Electronic Nicotine Delivery Systems;examination questions;Feedback;Future;Health;health care delivery;health data;improved;Individual;innovation;Learning;Marketing;Measures;Mediating;Mediation;Mediator;Methodology;Methods;Modeling;Nicotine;nicotine use;Pattern;Perception;Persons;Policies;Policy Maker;Population;Population Assessment of Tobacco and Health;Public Health;Research;Research Support;response;Risk;risk perception;secondary analysis;semiparametric;social influence;social media;Source;substance use;Surveys;Techniques;Time;Tobacco;tobacco advertising;tobacco control;tobacco products;Tobacco use;United States;Update;Youth

PROJECT_TITLE: Does Tobacco Social Media Marketing Alter Adolescent Risk Perceptions and Use? Longitudinal Data-Adaptive Estimators and Causal Inference to Enhance Understanding


ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PI_NAMEs: LEVY, PHILLIP DAVID (contact)

PROJECT_TITLE: ACHIEVE GreatER: Addressing Cardiometabolic Health Inequities by Early PreVEntion in the Great LakEs Region


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PHR: Hepatocellular carcinoma (HCC) is a feared complication of liver cirrhosis and has unacceptably high mortality. Prevention of HCC is a major need but a great challenge because it needs large, long trials. We will use a promising HCC risk marker as a surrogate to define the efficacy of statins for HCC chemoprevention.

PI_NAMEs: CHUNG, RAYMOND T;DIEHL, ANNA MAE ELIZABETH;HOSHIDA, YUJIN  (contact);MOYLAN, CYNTHIA A

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: arm;atorvastatin;Biological Markers;cancer chemoprevention;case control;Case/Control Studies;Characteristics;Chemoprevention;Cirrhosis;Clinical;clinical translation;Clinical Trials;cohort;Complication;Epigallocatechin Gallate;Erinaceidae;Erlotinib;Fright;Funding;Future;Goals;Guide prevention;Health;hydrophilicity;improved;Incidence;lipophilicity;Liver;Liver Cirrhosis;Longitudinal cohort study;Medical;mortality;Nature;novel strategies;Operative Surgical Procedures;Patients;Placebos;preclinical study;Prevention;Prevention therapy;Prevention trial;Primary carcinoma of the liver cells;Prognosis;prognostic;prospective;Prospective cohort;Proteomics;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;Recurrence;Refractory;Research Personnel;Retrospective Studies;Risk;Risk Marker;risk prediction;rosuvastatin;Sampling;Series;Serum;Signal Pathway;Signal Transduction;Surrogate Endpoint;Testing;Therapeutic;Validation

PROJECT_TITLE: Therapeutic modulation of a proteomic HCC risk signature with statins in patients with liver cirrhosis