ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE For persons living with dementia (PLWD), and particularly for those with serious illness, an Emergency Department (ED) visit is a critical event and an opportunity to address the unmet needs that preceded this visit. Our multiple PI (mPI) team, who have together conducted cluster-randomized, multi-site trials in >50 EDs as well as multiple hospice and home health agencies, is uniquely poised to address previous shortcomings in the development of scalable models of care for PLWD. The overarching goal of EDs LEading the Transformation of Alzheimer’s and Dementia Care (ED-LEAD) is to turn an ED visit from a crisis into an opportunity to improve the health and well-being of PLWD and their care partners.

PI_NAMEs: BRODY, ABRAHAM AIZER;CHODOSH, JOSHUA  (contact);GRUDZEN, CORITA R;SHAH, MANISH N

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Address;Advance Care Planning;Alzheimer's Disease;Alzheimer's disease related dementia;Behavioral Symptoms;Bioinformatics;Biometry;care recipients;Caring;Case Management;Characteristics;clinical decision support;Collaborations;Communication;Communities;comorbidity;contextual factors;data management;Dementia;dementia care;design;Development;digital;Effectiveness;effectiveness study;effectiveness testing;Emergency Care;Emergency department visit;Emergency Situation;Emotional;Engineering;Ensure;ethnic diversity;Event;Family;Friends;Funding;Goals;Health;Health system;high risk;Home;Home Health Agency;hospice environment;Hospitalization;improved;indexing;Individual;Intervention;intervention delivery;Logistics;Medicine;Mental Depression;Methods;Modeling;Monitor;mortality;multi-site trial;multidisciplinary;novel;Nurses;older adult;Paramedical Personnel;Participant;Pathway interactions;Patients;Personal Satisfaction;Persons;Policies;Population;Population Heterogeneity;primary outcome;Process;programs;Provider;psychological symptom;Quality of life;racial diversity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Research Personnel;Resources;Running;Services;Site;Statistical Data Interpretation;Stress;Structure;Surrogate Endpoint;Telephone;Testing;therapy design;Time;United States National Academy of Sciences;usability;Variant;Visit;Vulnerable Populations;Work

PROJECT_TITLE: ED-LEAD: Emergency Departments LEading the transformation of Alzheimer's and Dementia care


ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Emergency Care;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: NY

PI_NAMEs: CHODOSH, JOSHUA  (contact)

PROJECT_TERMS: Accident and Emergency department;Alzheimer's Disease;Caring;Case Management;Catalogs;Classification;clinical decision support;Collaborations;college;Communication;Communities;community setting;Complex;Dementia;dementia care;design;Discipline;Discipline of Nursing;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Medicine;Ensure;experience;Funding;Future;Goals;Grant;Health system;Home;Hospitalization;Human Resources;human subject;improved;Infrastructure;insight;Institutional Review Boards;interoperability;Intervention;Knowledge;Lead;Leadership;Lived experience;medical schools;meetings;member;Memorial Sloan-Kettering Cancer Center;Methodology;Nurses;Occupational activity of managing finances;older adult;Paramedical Personnel;Peer Review;Persons;pragmatic trial;preservation;Procedures;Process;Protocols documentation;Public Health;Publications;recruit;Research;Research Infrastructure;Research Personnel;Resources;Role;Rural;Scientist;Seasons;Site;Structure;success;Telephone;Training;Universities;web site;Wisconsin;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Immunotherapy;Orphan Drug;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project 2 - Narrative Radiation-Induced Lymphopenia: Understanding, Predictive Modeling and Developing Photon and  Proton-Based Mitigation Strategies Radiation therapy (RT), a key pillar of cancer management, causes a common, yet often ignored, side effect – immune system suppression (i. e., radiation-induced lymphopenia [RIL]). Severe RIL has been linked to poor cancer treatment outcomes, presumably due to the reduced tumor surveillance by the immune system, thereby increasing disease recurrence and distant metastasis after RT. We propose approaches to identify clinical and dosimetric factors that predict the risk and severity of RIL and understand the impact of RIL on the immune diversity and profile as it affects clinical outcomes; to develop models that can accurately predict the risk of RIL individualized to a patient’s baseline clinical factors; and to use such models in the optimization of radiation dose distributions to mitigate RIL and its impact on outcomes.

PI_NAMEs: LIN, STEVEN HSESHENG (contact)

PROJECT_TERMS: Adaptive Immune System;Affect;Biological Factors;Cancer Patient;cancer therapy;cancer type;CD8-Positive T-Lymphocytes;Cells;Characteristics;Clinical;clinical practice;clinical prognostic;clinical translation;clinically relevant;clinically significant;Computer Simulation;Cytometry;cytotoxic;cytotoxicity;Data;Databases;Development;Disease;Disease Outcome;Distant Metastasis;DNA Damage;Dose;evidence base;experimental study;Fractionation;functional status;Future;Goals;Heterogeneity;high risk;Immune;Immune system;Immunity;Immunologic Surveillance;immunological diversity;immunological status;Immunosuppression;Immunotherapy;improved;improved outcome;Incidence;individual patient;Intensity-Modulated Radiotherapy;Ionizing radiation;Link;Location;Lymphocyte;Lymphocyte Count;Lymphocyte Depletion;Lymphocyte Subset;Lymphopenia;Machine Learning;Malignant neoplasm of brain;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mediating;Mediator;Modality;Modeling;optimal treatments;Outcome;Patient risk;patient subsets;Patients;Pattern;personalized approach;personalized care;personalized predictions;personalized strategies;Phenotype;Photons;population based;Pre-Clinical Model;Predictive Factor;predictive modeling;Predisposition;preservation;Process;Prognostic Factor;prospective;proton therapy;Protons;Radiation;Radiation Dose Unit;radiation mitigation;radiation risk;Radiation therapy;Radiation Tolerance;Radiation-Induced Cancer;Recurrent disease;Regimen;Research;Risk;risk mitigation;risk prediction;risk prediction model;Roentgen Rays;Role;Selection for Treatments;Severities;side effect;Site;Solid Neoplasm;Structure;T cell clonality;T-cell diversity;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;therapy outcome;Time;treatment optimization;Treatment outcome;treatment planning;tumor;Tumor Immunity;Tumor Volume;Vaccination;Work

PROJECT_TITLE: Project 2: Radiation-Induced Lymphopenia: Understanding, Predictive Modeling and Developing Photon and Proton-Based Mitigation Strategies.


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Challenging physical or social experiences in early life can have long-lasting effects on individual health. The proposed work will leverage two well-established, unique human cohorts as well as new lab-based, experimental assays to investigate the gene regulatory mechanisms that underlie this relationship as well as the genetic factors that predict individual susceptibility versus resilience. In doing so, this work will improve our understanding how early life experiences become “embedded” into lifelong physiology, our appreciation of the role genotype x environment interactions play in this process, and our insight into intervention strategies that are likely to be effective and that appropriately target individuals at high risk of poor outcomes.

PI_NAMEs: LEA, AMANDA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adult;African;Amerindian;Biological Assay;Bolivia;cohort;Complement;Complex;Data;Data Set;Development;DNA Methylation;early life exposure;effective intervention;Environment;experience;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Variation;genome-wide;Genotype;Health;high risk;Human;improved;Individual;insight;inter-individual variation;Intervention;Kenya;Knowledge;late life;Life;Life Experience;Life Style;Link;Marketing;Mediating;Methods;Molecular;Outcome;Pattern;Physically Challenged;Physiology;Play;Population;Predictive Factor;Predisposition;Process;programs;Regulatory Element;Research;resilience;Resources;Role;social;Stimulus;Testing;trait;Underserved Population;Urbanization;Variant;Work

PROJECT_TITLE: Early life environmental effects: molecular mechanisms and inter-individual variation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Emergency Care;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: GRUDZEN, CORITA R (contact)

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Alzheimer's Disease;Caring;clinical decision support;Collaborations;college;Communication;Communities;community setting;Complex;contextual factors;Data;Dementia;dementia care;design;Discipline of Nursing;Documentation;Dose;Electronic Health Record;Emergency Care;Emergency department visit;Ensure;experience;Frequencies;Goals;Health;Health system;Human Resources;implementation barriers;implementation science;implementation strategy;improved;Informatics;Intervention;Lead;Leadership;learning network;Lived experience;Measures;medical schools;member;Methods;Monitor;Needs Assessment;Nurses;older adult;Outcome;Paramedical Personnel;peer;peer learning;Persons;Physicians;pilot test;pragmatic trial;Procedures;Process;Provider;Readiness;Report (document);Research Infrastructure;Research Personnel;Role;Rural;Scientist;Seasons;Site;Social Work;Specific qualifier value;Statistical Data Interpretation;success;support tools;Telephone;Testing;Time;tool;Training;Universities;usability;Wisconsin;Work

PROJECT_TITLE: Implementation Core


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Diabetes;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

ORG_CITY: NEWTON

ORG_NAME: THINK THERAPEUTICS, INC.

PHR: Project Narrative Autoimmune diseases are caused by immune system cells that have escaped normal controls and inappropriately seek out our normal cells for destruction. These bad killer cells recognize specific normal protein sequences on a cell’s surface as a signal to kill it. We will develop an assay to discover what sequences these bad killer cells recognize, and use the assay to discover normal sequences relevant to Type 1 Diabetes. Once we know what normal sequences these killer cells recognize we can use the sequences to design a vaccine that regulates their killing.

PI_NAMEs: GIFFORD, DAVID K (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Admission activity;Alleles;Amino Acid Sequence;antigen test;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;Biological Assay;Businesses;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell surface;Cells;Code;Collaborations;Computing Methodologies;cross reactivity;Cytotoxic T-Lymphocytes;Data;Databases;Derivation procedure;design;Diabetes Mellitus;Epitopes;Foundations;FOXP3 gene;Frequencies;Haplotypes;high throughput screening;HLA-A gene;Human;Immune;Immune system;immunogenicity;Immunologic Surveillance;improved;Individual;Insulin-Dependent Diabetes Mellitus;Killer Cells;Legal patent;Letters;Literature;Lymphocyte;Machine Learning;machine learning framework;machine learning method;Mass Spectrum Analysis;Massachusetts;medical schools;Methods;MHC Class I Genes;MHC Class II Genes;mRNA lipid nano particle vaccine;Normal Cell;novel;Peptide/MHC Complex;Peptides;Peripheral Blood Mononuclear Cell;Persons;Population;preproinsulin;prevent;Proteins;receptor;receptor binding;Recovery;Regulatory T-Lymphocyte;Research;response;Sampling;Signal Transduction;Symptoms;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Universities;vaccination outcome;Vaccine Design;vaccine evaluation;Vaccines;Work

PROJECT_TITLE: Machine learning optimized autoimmune therapeutics with a focus on Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Home-Based Primary Care (HBPC) is a distinctive home care program for Veterans with complex chronic disease at high risk of long-term institutionalization and HBPC enrollment is associated with lower hospitalization risk and reduced costs. Expansion of HBPC by 75 sites is planned by fiscal year 2026. However, there is substantial variation in individual HBPC sites in program structure, patients served, and clinical outcomes. It is unknown if this variation represents variable fidelity to the HBPC clinical model or appropriate flexibility and adaptation to local context. In this mixed-methods study, we will perform a detailed exploration of variation in HBPC program, identify configurations of HBPC site features associated with high performance in patient home time, a novel patient-centered outcome, and elucidate mechanisms of success using configurational analysis, an emerging mixed-methods approach.

PI_NAMEs: EDWARDS, SAMUEL T (contact)

PROJECT_TERMS: Address;Adopted;aging in place;analytical method;Behavioral;Binding Sites;care delivery;Caregiver support;Caregivers;Caring;Case Study;Characteristics;Chronic;Chronic Disease;Client satisfaction;Clinical;clinical care;Cluster Analysis;community based service;comorbidity;Complex;contextual factors;cost;Data;demographics;Development;Effectiveness;effectiveness/implementation trial;Emergency Care;end of life care;Enrollment;flexibility;Future;Geriatrics;Goals;Health;Health Care Costs;high risk;holistic approach;Home;Home visitation;Hospice Care;Hospitalization;Hospitals;improved;Individual;innovation;Institution;Institutionalization;Intervention;Interview;Long-Term Care;Mathematics;Measures;Medical;Medicare;meetings;member;Methodology;Methods;Mission;Modeling;novel;Nurses;Nursing Homes;Outcome;Outcome Measure;palliative;patient home care;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Patterns of Care;Performance;Population;Primary Care;primary care clinician;primary care patient;primary care team;Process;programs;Quality of life;Recurrence;Regression Analysis;Research;Risk;Services;Site;social;Structure;success;Testing;theories;Time;Urbanicity;Variant;Veterans;Visualization;Work

PROJECT_TITLE: Defining Successful Program Configurations in Home-Based Primary Care

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Radiation Oncology

PHR: PROJECT 3 - NARRATIVE The proposed research is relevant to public health in that the discovery of novel biological effects of proton therapy as well as biomarkers predictive of response, is expected to transform our understanding of DNA damage response following particle irradiation and identify patients who will have favorable responses to proton therapy. Thus, the proposed studies are relevant to the National Cancer Institute and its mission to support research to improve cancer treatment and rehabilitation.

PI_NAMEs: GROSSHANS, DAVID R (contact)

PROJECT_TERMS: Area;Back;Bioinformatics;Biological;Biological Assay;Biological Factors;Biological Markers;biomarker identification;biomarker validation;biophysical model;Brain;Breast;cancer cell;Cancer cell line;Cancer Patient;cancer rehabilitation;cancer therapy;cancer type;candidate identification;candidate marker;Cell Line;Cells;Characteristics;Clinical;Clinical Trials;clinically relevant;Collection;Computational Technique;Data;Defect;Deposition;Derivation procedure;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA mapping;DNA Repair;DNA Repair Pathway;Dose;Double Strand Break Repair;Esophagus;Excision;Funding;Future;Gene Expression Profile;Gene Mutation;genomic biomarker;genomic locus;genomic profiles;Genomics;Goals;improved;in vivo;Individual;individual patient;innovation;Institution;Interdisciplinary Study;irradiation;Knowledge;Linear Energy Transfer;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mission;Modeling;molecular marker;Mus;National Cancer Institute;Normal tissue morphology;novel;Nucleosomes;Organoids;Pancreas;particle;Pathway interactions;Patient Selection;Patients;Photons;pre-clinical;predicting response;predictive marker;Predisposition;Property;proton beam;proton therapy;Protons;Public Health;Radiation;Radiation therapy;Reaction;Relative Biological Effectiveness;repaired;Research;Research Support;Resolution;response;Site;small molecule inhibitor;Specimen;Stratification;Stratification Factors;Study models;synergism;Techniques;Testing;Therapeutic;therapeutic DNA;tool;Toxic effect;tumor;Tumor Cell Biology;University of Texas M D Anderson Cancer Center;Validation;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Emergency Care;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: GOLDFELD, KEITH  (contact)

PROJECT_TERMS: Accident and Emergency department;Alzheimer's Disease;analytical method;arm;Attention;Bayesian Modeling;Biometry;Caring;Characteristics;Cluster randomized trial;Collaborations;Collection;Communities;Complex;Computing Methodologies;Consult;Consultations;Data;Data Analyses;data exploration;data management;Databases;Dementia;dementia care;design;Elements;Emergency Care;Ensure;Equilibrium;experimental study;Foundations;Goals;Graph;Health;Health Personnel;Health Policy;Health system;Healthcare Systems;implementation evaluation;implementation fidelity;implementation outcomes;improved;Individual;Intervention;Joints;Lead;Link;Location;Manuscripts;Measures;Medical Care Team;Methodology;Modeling;Monitor;Nurses;Outcome;Outcome Measure;Paramedical Personnel;Patients;Persons;Policy Maker;Pragmatic clinical trial;Process;Randomized;Reporting;Research;Research Personnel;Sample Size;Scheme;Site;Statistical Data Interpretation;Statistical Methods;statistics;Structure;System;Telephone;tool;Training;trial design;Validity and Reliability;Vulnerable Populations;Work

PROJECT_TITLE: Statistics Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: ALBUQUERQUE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE There is a critical underrepresentation of cancers from American Indian patients in national cancer genome databases. Additionally, American Indians have the poorest cancer survival rates of all ethnicities in the United States. The goal of this proposal is to engage with American Indian communities and individuals in order to increase their understanding and participation in precision medicine, molecular characterization of tumors and cancer research with the long-term goal of reducing their cancer burden.

PI_NAMEs: TRENT, JEFFREY M.;WILLMAN, CHERYL LYNN (contact)

PROGRAM_OFFICER_NAME: MECHANIC, LEAH E

PROJECT_TERMS: Address;Agreement;Alaska Native;Alcohols;American Indian community;American Indian Tribe;American Indians;anti-cancer research;Behavior;Belief;biliary tract;Biological;Biological Markers;Breast;Cancer Burden;Cancer Etiology;cancer genome;cancer health disparity;Cancer Patient;cancer survival;Cancer Survivor;cancer type;Characteristics;Colorectal;Communication;Communities;community engagement;Data Commons;data sharing;Development;Diagnosis;Diet;differences in access;Disease;Disparity;DNA;Environmental Exposure;Ethnic Origin;Ethnic Population;Frequencies;Gallbladder;Genes;Genetic;Genome;genome database;genome sequencing;genome-wide;Genomics;Germ-Line Mutation;Goals;health care availability;Hepatitis;hepatobiliary cancer;Hormones;Human Papillomavirus;improved;Incidence;Indigenous;Individual;individualized prevention;Intervention;intravenous drug use;Kidney;Knowledge;Language;Liver;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Metabolism;Molecular;mortality;Mutation;Native Hawaiian or Other Pacific Islander;novel;novel diagnostics;Obesity;Outcome;Pancreas;Participant;patient engagement;Patients;personalized intervention;Policies;precision medicine;preventive intervention;Public Health;Publications;racial population;Religious Belief;Research;research study;Risk Behaviors;screening;Screening for cancer;Somatic Mutation;Stomach;Survival Rate;The Cancer Genome Atlas;Therapeutic Intervention;therapeutically effective;Tobacco;Translating;Translations;tribal community;Tribal Council;tribal Nation;Tribes;Trust;tumor;United States;United States National Institutes of Health;Urogenital Cancer;Vaccination;virtual;Virus;Visual

PROJECT_TITLE: Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHAMPAIGN

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Project Narrative: AMPA- and NMDA-type glutamate receptors are neurotransmitter receptors that regulate learning, memory and numerous neurodevelopmental and neurodegenerative diseases. We will develop new microscopy tools, probes, and methods to visualize their trafficking into and out of synapses at the nanometer level to help understand these processes.

PI_NAMEs: CHUNG, HEE JUNG ;SELVIN, PAUL R (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: 3-Dimensional;Alzheimer's Disease;Avidin;Binding;Biological Sciences;Cell membrane;Cells;Chemicals;Clinical;Color;Communication;Cross-Linking Reagents;crosslink;density;Diameter;Diffusion;dimer;Disadvantaged;Dissociation;DNA;DNA Probes;Dyes;Event;Evolution;experimental study;facsimile;Fluorescence;Fluorescence Microscopy;fluorophore;Future;Glutamate Receptor;Grant;Hippocampus;Homer 1;Image;imager;Imaging Device;improved;Individual;innovation;Label;Lateral;Learning;Length;Ligands;Long-Term Potentiation;Maintenance;Measurement;Measures;Memory;Methods;Microscopy;Molecular;monomer;N-Methylaspartate;nano;nanobodies;nanometer;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Neurosciences;Neurotransmitter Receptor;NMDA receptor A1;Parkinson Disease;Phase;Physiological;Positioning Attribute;postsynaptic;postsynaptic density protein;presynaptic;presynaptic density protein 95;Process;Proteins;Quantum Dots;receptor;Resolution;response;single molecule;Site;Speed;stoichiometry;Structure;Sulfhydryl Compounds;superresolution microscopy;Surface;Synapses;Synaptic Cleft;System;Techniques;Technology;temporal measurement;Testing;Thinness;Time;tool;trafficking;ultra high resolution;Visualization

PROJECT_TITLE: Super-Resolution Microscopy of Neuronal Synapses with Advanced Imaging Tools


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Emergency Care;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PROJECT_TERMS: Accident and Emergency department;acute care;Address;Adoption;Advance Care Planning;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease test;Area;care fragmentation;care providers;Caring;Characteristics;clinical decision support;Collaborations;Communication;Communities;Complex;Consultations;data acquisition;Delirium;Dementia;dementia care;deprivation;design;digital;Drug Prescriptions;Education;effective intervention;effectiveness study;effectiveness testing;Electronic Health Record;Emergency Care;Emergency Department Physician;Emergency department visit;Emergency Nursing;Emergency Situation;Engineering;Ensure;Environment;Ethnic Origin;evidence base;Face;Feedback;Goals;Health;Health Care Sector;health inequalities;Health system;Healthcare Systems;Home;Hospitalization;Iatrogenesis;implementation fidelity;improved;indexing;Informatics;Institutionalization;Instruction;Intervention;Knowledge;Lead;Managed Care Programs;Medicine;Mental Depression;Modeling;multidisciplinary;Needs Assessment;Nonpharmacologic Therapy;Notification;Nurse Practitioners;Nurses;Outcome;Paramedical Personnel;Pathway interactions;Patients;Persons;Physician Assistants;Physicians;Population;pragmatic intervention;pressure;primary outcome;Procedures;Process;programs;Provider;Psychological reinforcement;psychosocial;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Resources;response;Schedule;Site;skills;Social Work;Social Workers;Specific qualifier value;Structure;Symptoms;team-based care;Telephone;Testing;therapy design;Time;Training;United States;United States National Academy of Sciences;Variant;Visit;Work

PROJECT_TITLE: Emergency Care Redesign (ECR)


ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: Tens of millions of Americans suffer from chronic pain, and the epidemic of overdose deaths related to opioids makes it clear that safer treatments are needed. To help develop new, safer treatments, scientists must learn much more about the genes and cells that contribute to pain in humans. This application proposes a new center that will map the genes and cells associated with various types of pain, focusing on the peripheral nerves and spinal cord, to provide important new information to help with the development of new therapies.

PI_NAMEs: GEREAU, ROBERT W (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: addiction;Address;American;Anatomy;Animal Model;Atlases;axon regeneration;axonal degeneration;Catalogs;Cell Nucleus;cell type;Cells;Central Nervous System;Chromatin;Chromosome Mapping;chronic pain;chronic painful condition;Collaborations;Cytometry;Data;Data Collection;data ecosystem;Development;Doctor of Philosophy;Electrophysiology (science);Epidemic;evidence base;experience;Failure;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;Helping to End Addiction Long-term;Human;Human Biology;human tissue;Image;improved;Inherited;insight;Institute of Medicine (U.S.);Institution;International;Knowledge;Leadership;Learning;Location;Maps;molecular phenotype;Morphology;multiple omics;Neurobiology;Neuroma;Neurons;novel therapeutics;Opioid;opioid epidemic;opioid mortality;opioid use;overdose death;Pain;Pain Clinics;Pain Map;pain model;painful neuropathy;patch sequencing;Patient Care;Peripheral Nerves;Peripheral Nervous System Diseases;Physiological;Posterior Horn Cells;pre-clinical;Preparation;Price;programs;Property;Proteomics;Protocols documentation;Recording of previous events;Reporting;Research;Research Personnel;Resolution;Risk;Scientist;searchable database;single nucleus RNA-sequencing;Site;species difference;Spinal Cord;Spinal cord posterior horn;Spinal Ganglia;success;Testing;tissue processing;Tissue Procurements;Tissues;tool;transcriptome sequencing;transcriptomics;Translating;transmission process;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: INTERCEPT: Integrated Research Center for human Pain Tissues


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The current ROBIN proposal addresses a knowledge gap on how standard radiotherapy affects the patient’s immune system. By inviting patients newly diagnosed with rectal cancer to donate for research small tumor, stool and blood samples, collected during standard colonoscopy procedure (before and after standard treatment), we will create a bio-repository (a bank of tissues) to study the characteristics of the tumors that respond to radiation and those that don’t: this insight may help avoiding additional treatments in future patients and select others for more effective treatments. We have converged a team of outstanding scientists, physicists, clinicians and patient advocates to carry out this task.

PI_NAMEs: DEASY, JOSEPH O;FORMENTI, SILVIA C. (contact);WEICHSELBAUM, RALPH R

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;Address;Advocate;Affect;Age;Artificial Intelligence;biobank;bioinformatics tool;Biological;biological effect of radiation;Biology;Biopsy;Blood;Blood specimen;Cells;Cementation;Clinic;Clinical;Clinical Investigator;Clinical Trials;Collaborations;Colonoscopy;Colorectal;Communities;Complex;computer scientist;Consent;Data;data acquisition;data harmonization;data sharing;Dedications;Descriptor;design;Discipline;effective therapy;Environment;Europe;experience;Feces;Fertilization;Foundations;Future;Gender;Generations;Grant;Harvest;Human;Image;Imaging Techniques;Immune;Immune response;Immune system;Immunity;Immunologist;Immunology;Immunophenotyping;insight;Institution;International;international center;Investigation;Ionizing radiation;Irradiated tumor;Knowledge;longitudinal analysis;lymph nodes;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;meetings;microbiome;Modeling;Molecular;multiple omics;Neoadjuvant Therapy;Newly Diagnosed;next generation;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Oxidative Stress Induction;Patients;Peripheral Blood Mononuclear Cell;Physics;Preparation;Procedures;Process;prospective;Publications;Radiation;radiation effect;Radiation Oncology;Radiation therapy;Radiobiology;Radiometry;radiomics;Rectal Cancer;Regulation;Research;Resource Sharing;response;Sampling;Scientist;simulation;Sorting;Specimen;standard care;Standardization;stool sample;Structure;study characteristics;Survivors;synergism;System;Technology;Testing;Tissue Banks;Tissues;Training;Translations;tumor;Tumor stage;Tumor Tissue

PROJECT_TITLE: Dynamics of Immune Response in Irradiated Rectal Cancer


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE In African Americans, prostate cancer is characterized by higher aggressiveness, more extensive metastases, early- onset, and increased mortality rates than those in Caucasian Americans. We hypothesize that the racial disparity in prostate cancer diagnosis can be reduced by using racially associated magnetic resonance imaging (MRI) analysis. The proposed MRI-based analysis model will be evaluated for men of different racial/ethnic characteristics at the University of California Los Angeles (UCLA) and the University of Alabama at Birmingham (UAB).

PI_NAMEs: KIM, HARRISON ;SUNG, KYUNG HYUN  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3D Print;Address;African American;African American population;Age;Alabama;algorithm development;Anatomy;Biopsy;Blood Vessels;California;cancer diagnosis;Cancerous;caucasian American;Characteristics;Clinical;clinical research site;clinically significant;Computer software;contrast enhanced;Data;Data Set;Death Rate;deep learning algorithm;deep learning model;density;Detection;Diagnostic;digital;early onset;Ethnic Origin;Ethnic Population;Extracellular Space;Image;Imaging Techniques;improved;Incidence;Information Systems;Institution;Lesion;Link;Los Angeles;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Measurement;Measures;men;Modeling;Molds;Names;Neoplasm Metastasis;non-invasive imaging;Pathologic;Pathology;Patients;Performance;Perfusion;Peripheral;point of care;portability;predictive modeling;Prospective cohort;Prostate;Prostate-Specific Antigen;Prostatic Neoplasms;Race;racial disparity;Radical Prostatectomy;Radiology Specialty;recruit;Reporting;Reproducibility;Risk;Schedule;Scheme;Screening for Prostate Cancer;self-attention;Specific qualifier value;Specificity;Standardization;Testing;Tissues;tumor;tumor microenvironment;United States;Universities

PROJECT_TITLE: Racially-associated MRI analysis and modeling for predicting aggressive prostate cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is a highly lethal disease and is characterized by extensive hypoxic fibroinflammatory stroma which contributes to the ineffectiveness of immunotherapies. Interactions between tumor cells and surrounding stromal cells substantially influence immune suppression and tumor progression, and the goal of this proposal is to elucidate how hypoxia regulates the recruitment and function of macrophages in pancreatic cancer. My studies will expand our understanding of how hypoxia drives an immunosuppressive tumor microenvironment, and provide insight into the development of effective immunotherapeutic strategies against pancreatic cancer.

PI_NAMEs: HANNIFIN, SEAN MATTHEW (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Area;Blood Vessels;Cancer Etiology;CCL2 gene;cell type;Cells;Cessation of life;chemokine;Coculture Techniques;Communication;cytokine;Data;density;Development;Disease;Disease Progression;effective therapy;Environment;Exclusion;experience;Fibrinogen;Fibroblasts;Gene Expression;Goals;HIF1A gene;Human;Hypoxia;Hypoxia Inducible Factor;Immune;Immune System Diseases;Immunosuppression;immunosuppressive macrophages;Immunotherapeutic agent;Immunotherapy;Infiltration;Inflammatory;insight;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;migration;Modeling;monocyte;Mus;Myelogenous;neoplastic cell;neutralizing antibody;normoxia;Outcome;Oxygen;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;pancreatic tumorigenesis;Patients;Phenotype;Play;Population;recruit;Regulation;Resistance;response;Role;Signal Transduction;Stress;Stromal Cells;Survival Rate;T-Lymphocyte;Testing;therapy resistant;transcription factor;tumor;tumor hypoxia;tumor progression;tumor-immune system interactions;United States

PROJECT_TITLE: Hypoxic regulation of macrophage migration and function via fibroblast reprogramming in pancreatic cancer


NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Stem cells hold great potential for advancing public health, given their critical role in the growth and maintenance of tissues. In addition, many therapies in regenerative medicine are focused on the use of stem cells to replace damaged or missing tissues. Hydractinia represents a new and powerful animal research organism for identifying the molecular and cellular mechanisms that regulate and guide stem cells during homeostasis and regeneration, and the understanding of these mechanisms gained from this project will significantly inform the field of regenerative medicine.

PI_NAMEs: SCHNITZLER, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Animal Experimentation;Animals;Cell Cycle;Cell Maintenance;Cells;Characteristics;Cnidaria;Development;Embryo;Event;Experimental Genetics;gain of function;Gene Expression Profiling;Generations;Genes;Genome;genome resource;Goals;Growth;Homeostasis;Human;in vivo;Invertebrates;Life;loss of function;Maintenance;marine;Mediating;model organism;Molecular;Natural regeneration;Nature;Normal tissue morphology;Organism;Population;Proliferating;Public Health;regenerative;regenerative biology;Regenerative capacity;Regenerative Medicine;Regenerative research;Research;Role;single-cell RNA sequencing;stem cell function;stem cell population;stem cells;System;tissue regeneration;Tissues;tool;trait;Transgenic Organisms;Vision;Work

PROJECT_TITLE: Characterizing the molecular regulators of stem cell populations during homeostasis and regeneration in Hydractinia, an emerging cnidarian research organism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Cancer;Radiation Oncology

PHR: ADMINISTRATIVE CORE - NARRATIVE The purpose of Administrative Core is to provide centralized scientific and administrative management, financial control services, and clerical and materials management support to all projects and cores. The Administrative Core will coordinate research among projects and cores, monitor progress and resolve issues as they arise. It will provide necessary support for the organization and conduct of the Steering Committee /Internal Advisory Board meetings, the annual Investigator Meeting and Retreat with the External Advisory Board, and monthly or as-needed telephone, video, and web conferences.

PI_NAMEs: HONG, THEODORE S (contact)

PROJECT_TERMS: Biological;Biological Factors;biological research;Cancer Center;Clinical;Clinical Research;Collaborations;college;Communication;Complex;Data;Ensure;Feedback;Funding;General Hospitals;Goals;Health Sciences;Individual;Institution;Internet;Massachusetts;Medicine;meetings;Modeling;Monitor;Occupational activity of managing finances;Office of Administrative Management;Online Systems;Participant;Patients;Personnel Management;Photons;Physics;Policies;Program Research Project Grants;programs;Progress Reports;Protons;Qualifying;Radiation therapy;Recommendation;Research;Research Personnel;Research Priority;Resources;Rice;Sampling;Schedule;Scientist;senior faculty;Services;Site;symposium;Telephone;Texas;Universities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Many neurological and neuropsychiatric disorders are associated with characteristic motor abnormalities; e.g., patients with Tourette syndrome, dystonia, autism spectrum, and obsessive compulsive disorders typically show repetitive motor behaviors. In rodent disease models, compulsive repetitive behaviors often manifest as excessive grooming and the striatum plays critical roles in patterning and execution of this stereotyped motor output. A better understanding of how striatal circuits mediate grooming behavior may shed light on neurobiological control of repetitive behaviors in normal and pathological conditions.

PI_NAMEs: FUCCILLO, MARC V;MA, MINGHONG  (contact);WESSON, DANIEL W

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Ablation;Animals;Arousal;autism spectrum disorder;Behavior;Behavior Control;behavioral phenotyping;Brain;brain control;Brain region;Calcium Signaling;Characteristics;Classification;Cognitive;Corpus striatum structure;Disease;disease model;Dopamine;dopamine D3 receptor;Dopamine Receptor;dopaminergic neuron;Dystonia;Electrophysiology (science);Fiber;Functional disorder;Genetic;Gilles de la Tourette syndrome;granule cell;Grooming;Human;Hygiene;in vivo;Individual;Induced Neurons;insight;Interneurons;Islands of Calleja;Lead;Lesion;Maintenance;Mammals;Measures;Mediating;Midbrain structure;Modernization;Monitor;Motor;motor behavior;motor control;Motor output;nerve supply;Nervous System Disorder;neural;neural circuit;Neurobiology;Neurological Models;Neurons;neuropsychiatric disorder;neuroregulation;Neurosciences;Neurotransmitters;novel;Obsessive-Compulsive Disorder;Olfactory tubercle;optogenetics;Output;Pathologic;Patients;Pattern;Photometry;Physiologic Thermoregulation;Play;Population;Regulation;repetitive behavior;response;Rodent Diseases;Role;Self Direction;sensor;Signal Transduction;social communication;Stereotyping;stress reduction;Structure;Synapses;Testing;Ventral Striatum;virtual;Work

PROJECT_TITLE: Novel Role of a Ventral Striatal Circuit in Motor Control


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Rheumatoid arthritis (RA) is a chronic autoimmune disease that is common in the veteran population. The current and newer therapies are fairly effective at decreasing the morbidity of RA but still have unintended consequences. One commonality of all of the disease-modifying antirheumatic drugs (DMARD) therapies is that they are immunosuppressive in a variety of ways. Analysis of response to the new recombinant zoster vaccine (RZV) in RA patients proposed in this study has direct clinical relevance and translational potential. It may influence the choices of therapies to be utilized as there are many options for treating RA. It could provide data that supports a clinical trial using drug windowing where the immunemodulatory drug is withheld transiently after vaccination to improve the response. It has been shown recently in RA patients that windowing methotrexate after influenza vaccination was beneficial to the anti-influenza response elicited.

PI_NAMEs: CANADAY, DAVID H (contact)

PROJECT_TERMS: Acute;Adjuvant;Adult;Adverse event;adverse event monitoring;Age;Aged, 80 and over;anti-influenza;Antibodies;Antimetabolites;Attenuated Vaccines;Autoimmune;Biological;Blinded;CD4 Positive T Lymphocytes;Cellular Immunity;Chickenpox;chronic autoimmune disease;Chronic pain syndrome;Clinical;clinical efficacy;clinical translation;Clinical Trials;clinically relevant;Communicable Diseases;Complication;Data;Dermatologic;Disease;Disease-Modifying Second-Line Drugs;Drug usage;effective therapy;Event;FDA approved;Flare;Future;gastrointestinal;General Population;Glycoproteins;Herpes zoster disease;Humoral Immunities;Immune;Immunity;immunogenicity;Immunologics;immunosuppressed;Immunosuppression;improved;Individual;Infection;Inflammatory Arthritis;Influenza vaccination;innovation;Laboratories;lifetime risk;Measures;Mediating;Methotrexate;military veteran;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;Names;novel therapeutics;Observational Study;Opportunistic Infections;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Postherpetic neuralgia;Prevalence;Primates;Recombinants;Regimen;responders and non-responders;response;Rheumatoid Arthritis;Rheumatology;Risk;Stroke;Subunit Vaccines;Systems Biology;Therapeutic immunosuppression;thrombotic;translational potential;tumor necrosis factor-alpha inhibitor;Vaccination;vaccine efficacy;vaccine immunogenicity;Vaccines;Virus;Work;Zoster Vaccine

PROJECT_TITLE: Immunogenicity of recombinant zoster vaccine in Rheumatoid arthritis patients


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lead Poisoning;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative East Trenton is an environmental justice community that bears a disproportionate burden of lead exposure in addition to low income, high population of less than high school education, and large minority population. This project’s goal is to identify lead exposure pathways within this community using citizen science, providing risk reduction strategies, and testing their efficacy. This project is a potential model for mitigating exposure risk in other lead burdened communities.

PI_NAMEs: STRATTON, SEAN  (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: 6 year old;Abate;Affect;Behavioral;Biological;Blood;blood lead;Blood specimen;Body System;Brain;Central Nervous System;Ceramics;Child;Child Health;China;Cities;citizen science;Cognitive;Collaborations;Communities;community based research;community burden;community clinic;community organizations;community partners;Complex;Data;design;Development;drinking water;Dust;Education;efficacy testing;Elements;Environment;Environmental Health;environmental justice;exposed human population;exposure pathway;Exposure to;Fellowship;Fingerprint;follow-up;Future;Goals;Guidelines;hazard;Health;Heavy Metals;high school;Home;Home environment;home test;Home visitation;House Dust;Household;improved;indexing;Individual;Inductively Coupled Plasma Mass Spectrometry;Industry;Information Dissemination;Ingestion;Inhalation;interest;Intervention;Isotopes;Knowledge;Lead;lead exposure;Lead levels;lead paint;Low income;Measures;Metals;Minority Groups;Modeling;Municipalities;Neighborhoods;Nervous System;neurodevelopmental effect;New Jersey;Paint;particle;people of color;Population;Poverty;Property;Public Health;racial disparity;Recommendation;Reporting;Research;Risk;Risk Factors;risk mitigation;Risk Reduction;Sampling;Screening procedure;Soil;soil lead;soil sampling;Source;stable isotope;System;Techniques;Testing;Toxic effect;Toxic Environmental Substances;Tracer;Training;United States Environmental Protection Agency;Urbanization;Visit;volunteer;ward;Writing

PROJECT_TITLE: Creating Pb Risk Mitigation Using Source Apportionment in an EJ Community

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Physical Rehabilitation;Preterm, Low Birth Weight and Health of the Newborn;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE Cerebral palsy (CP) is one of the most prevalent and costly developmental disabilities in the United States. Current research and therapeutic interventions related to mobility for transition aged persons with CP is lacking. This project will use clinical mobility outcomes and neurophysiological assessments to probe if a novel robotic exoskeleton gait training protocol will drive beneficial neuroplasticity in transition aged persons with CP.

PI_NAMEs: BUSBOOM, MORGAN  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Adolescence;Adult;aging population;Area;Attention;Biomechanics;Body Weight;Brain;Brain imaging;Cerebral Palsy;Clinical;Clinical Trials;clinically relevant;cohort;Compensation;cost;Data;Deterioration;Developmental Disabilities;Devices;Direct Costs;disparity elimination;Economic Burden;Employment;empowerment;Exhibits;exoskeleton;Experimental Designs;Funding;Gait;gait rehabilitation;H-Reflex;Health;Hoffman's Reflex;improved;improved mobility;innovation;interest;Interneurons;Investigation;Joints;kinematics;Learned Helplessness;Leg;Link;Literature;Locomotion;Lower Extremity;Magnetoencephalography;Measures;Mediation;member;Metabolic;meter;Mobility decline;Motor;motor learning;Muscle;Nervous System;neuromuscular activity;Neuronal Plasticity;neurophysiology;novel;Outcome;Participant;patient population;Patients;Perinatal Brain Injury;Persons;Physical therapy;Preparation;primary outcome;Protocols documentation;Research;robot exoskeleton;Societies;spatiotemporal;Spinal Cord;success;Surface;Testing;Therapeutic;Therapeutic community technique;Therapeutic Intervention;Time;tool;Training;treatment strategy;United States;United States National Institutes of Health;Walking;walking speed;Well in self;Withdrawal

PROJECT_TITLE: Robotic Exoskeleton Gait Training in Transition Aged Persons with Cerebral Palsy


NIH_SPENDING_CATS: Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Radiation Oncology

PHR: CORE 1: COMPUTATIONAL - NARRATIVE The significance of Core 1 lies in the accumulation and maintenance of detailed clinical and physical data necessary to enable studies correlating outcomes with the physical and or biological doses radiation delivered. In doing so, we will gain new knowledge into the true biological effectiveness of protons vs. photons in relation to the underlying physical factors. Our gained knowledge and integrated data collection will be introduced into clinical treatment planning systems in order to improve decision-making and outcomes for all patients treated with protons vs. photons.

PI_NAMEs: TITT, UWE  (contact)

PROJECT_TERMS: access restrictions;Address;Biological;Biological Factors;Biostatistics Core;Clinical;Clinical Treatment;Collaborations;Collection;Computer software;Correlation Studies;Correlative Study;Data;Data Collection;data exchange;data integration;data integrity;data management;Data Security;Data Set;data sharing;Data Storage and Retrieval;Database Management Systems;Databases;Decision Making;Dependence;design;Digital Imaging and Communications in Medicine;Dose;dosimetry;Effectiveness;Elements;Enrollment;Ensure;Excision;Experimental Designs;experimental study;Extramural Activities;follow-up;Funding;Goals;Grant;Image;immunoregulation;improved;In Vitro;in vivo;Individual;Infrastructure;insight;Institution;inter-institutional;interest;Intervention;Intuition;irradiation;Knowledge;Laboratory Study;Legal;Linear Energy Transfer;Link;Maintenance;Manuals;Monte Carlo Method;Names;Nomenclature;novel;Organ;Outcome;Patients;Performance;Photons;pre-clinical research;Process;Program Research Project Grants;prospective;Protons;quality assurance;Radiation Dose Unit;Radiation exposure;Radiation therapy;radiomics;Randomized;Relative Biological Effectiveness;repository;Research;research and development;Research Personnel;Risk;Safety;Scheme;Services;simulation;Standardization;Structure;structured data;System;Techniques;Testing;Time;tool;treatment planning;United States National Institutes of Health;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Core 1: Data Management and Computational Support Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PI_NAMEs: BRODY, ABRAHAM AIZER (contact)

PROJECT_TERMS: Academy;access disparities;Accident and Emergency department;Acute;Address;Advance Care Planning;Alzheimer's Disease;Alzheimer's disease related dementia;Ambulatory Care;Area;arm;Behavioral Symptoms;care coordination;care fragmentation;care systems;Caring;Case Management;Cessation of life;Characteristics;Chronic;Cluster randomized trial;Communities;comorbidity;cost effective;Data;Delirium;Dementia;dementia care;deprivation;design;Drug Prescriptions;Effectiveness;effectiveness study;effectiveness trial;Emergency Care;Emergency department visit;Ensure;Ethnic Origin;evidence base;Exclusion;Health;health care service utilization;health equity;health inequalities;health plan;Health system;Healthcare Systems;Home;Hospitalization;Iatrogenesis;implementation fidelity;improved;indexing;Individual;Inequity;Institutionalization;Intervention;Intervention Trial;Lead;Medicare claim;Medicine;Modality;novel;Nurses;Outcome;Outpatients;pain symptom;palliative;Palliative Care;Paramedical Personnel;patient oriented;Patients;Persons;Population;Population Heterogeneity;Pragmatic clinical trial;pragmatic trial;primary outcome;Procedures;Process;programs;Provider;psychological symptom;Quality of Care;Quality of life;Race;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Site;social;social health determinants;success;Surrogate Endpoint;symptom management;Telephone;Testing;Time;United States Agency for Healthcare Research and Quality;user centered design;Variant;Visit;Work

PROJECT_TITLE: Nurse Led Telephonic Care


ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: Project Narrative RNAs perform important regulatory functions that make them attractive as disease biomarkers, therapeutics, or therapeutic targets. This project is aimed at developing user-friendly new technologies for the detection and analysis of various RNAs. Ultimately, these simple and inexpensive techniques will accelerate the pace of discovery in RNA research to the benefit of human health.

PI_NAMEs: HALVORSEN, KEN A (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acceleration;Adopted;Area;Binding;Biological Assay;Biological Markers;Biology;Biosensing Techniques;Catalytic RNA;centrifuge force microscope;Chemicals;Collaborations;Communities;Complex;cost;Detection;Development;Development Plans;Disease;DNA;Drug Delivery Systems;Environment;FarGo;Health;Human;Individual;innovation;interest;Investments;Knowledge;Methods;Modification;Molecular;Molecular Conformation;nanoscale;Nanostructures;nanoswitch;Nanotechnology;new technology;Nucleic Acids;pandemic disease;Performance;Play;pre-clinical;Productivity;programs;Reagent;Reporting;Research;research and development;RNA;RNA Probes;RNA purification;RNA vaccine;RNA Viruses;Role;Science;single molecule;Structure;Structure-Activity Relationship;success;Techniques;Technology;technology development;Therapeutic;therapeutic target;Thermodynamics;tool;user-friendly;Vision;Work

PROJECT_TITLE: Manipulating nucleic acids: applications in RNA biosensing, single-molecule analysis, and DNA nanotechnology

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Project Narrative Most of the vertebrate genome finds its ultimate origin in transposable elements (TEs), and the thorough annotation of TEs is a critical aspect of genome annotation pipelines. We have developed an innovative open access database (Dfam) that yields substantial gains in TE annotation quality and provides numerous novel features in support of community TE curation. Here, we describe the necessary next steps for the expansion and improvement of the Dfam resource, capable of meeting the demands of large-scale genome reference projects and a broader research community.

PI_NAMEs: HUBLEY, ROBERT MACDONALD (contact);SMIT, ARIAN FREDERICUS ANTHONIUS;WHEELER, TRAVIS JOHN

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Biological databases;Classification;Collection;Common Data Element;Communities;community engagement;Complex;Computer software;Consensus Sequence;Data;Data Commons;Data Set;Databases;Detection;detection platform;Development;DNA;DNA Transposable Elements;Educational workshop;Elements;Evolution;Excision;experience;Family;Feedback;Fostering;Foundations;genetic information;Genome;genome annotation;genome-wide;Grant;Growth;Human Genome;Hybrids;improved;innovation;interest;Knowledge;Libraries;Licensing;Life;markov model;Medical;meetings;Metadata;method development;Methods;Modeling;Morphologic artifacts;mosaic;Mutation;novel;Polishes;pressure;Proteins;prototype;Publications;reconstruction;reference genome;Repetitive Sequence;Research;Research Institute;Resources;response;Scientist;Sequence Alignment;Sequence Analysis;Source;success;Training;trustworthiness;vertebrate genome;Work

PROJECT_TITLE: Dfam: sustainable growth, curation support, and improved quality for mobile element annotation


NIH_SPENDING_CATS: Natural Products

ORG_CITY: SAN ANTONIO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Narrative This project will investigate the chemistries of a group of enzymes involved in the biosynthesis of crucial building blocks of natural products with antibiotic and anticancer properties. The biochemistry of secondary metabolism learned from this study will deepen the understanding of synthetic pathways and regulation toward bioactive molecules. The knowledge procured will also help design and expand the repertoire of chemical compounds with desired biological activities beneficial for human health.

PI_NAMEs: LIU, AIMIN  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TITLE: Heme-Dependent Chemistry in Aromatic Oxidation


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Precision Medicine;Radiation Oncology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: CORE 2: TRANSLATIONAL BIOSPECIMEN AND IMAGING BIOMARKER - NARRATIVE The Translational Biospecimen and Imaging Biomarker Core Component (Core 2) is building a unique centralized resource to support biospecimen and imaging data collection from radiation-treated patients, will support sample processing and sharing using standardized protocols. Such activities will be carried out for patients enrolled on the NIH-funded clinical trials as well as from other clinical studies of radiotherapy relevant to the hypotheses tested in this grant. Core 2 will establish a database repository with the goals of: (i) creating a standardized patient consent and enrollment process to create efficiencies of scale; (ii) streamlining logistics and processes, reducing redundancy and maximizing the use of human and laboratory resources; (iii) diminishing data loss due to inconsistencies between protocols; and (iv) creating a central resource for translational research and molecular studies at the MD Anderson and MGH Cancer Centers.

PI_NAMEs: SHAITELMAN, SIMONA  (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;automated segmentation;Basic Science;Biological;Biological Factors;Biological Markers;Biopsy Specimen;Blood;Brain;cancer care;Cancer Center;Cancer Patient;Cardiology;Cardiopulmonary;Catalogs;cell culture collection;Cell Line;Central Nervous System;Characteristics;circulating biomarkers;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;Collection;Consent;Data;Data Collection;data de-identification;data exchange;Data Set;Databases;Dedications;Development;Dose;Enrollment;experience;Functional Imaging;Funding;General Hospitals;Goals;Grant;Hepatic;Human;human tissue;Image;Image Analysis;imaging biomarker;imaging modality;Immune system;Immunologics;Immunophenotyping;Immunosuppression;improved;In Vitro;in vivo;individualized medicine;Informed Consent;innovation;Institution;interest;Laboratories;liver imaging;Logistics;Lung;Lymphocyte;Magnetic Resonance Imaging;Massachusetts;Medical;Mission;Molecular;Normal tissue morphology;novel;Oncology;participant enrollment;particle therapy;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;personalized medicine;Photons;Physicians;pre-clinical research;precision medicine;Procedures;Process;Program Research Project Grants;prospective;Protein Analysis;Protocols documentation;proton therapy;Protons;Provider;Publications;Radiation;radiation adverse effect;Radiation Oncologist;Radiation therapy;Recommendation;repository;Research;Research Personnel;Resources;sample collection;Sampling;Scientist;Secure;Site;Specimen;Standardization;Technical Expertise;Testing;tissue culture;Tissues;Toxic effect;Translational Research;Treatment-related toxicity;Tumor Biology;Tumor Subtype;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Core 2: Translational Biospecimens and Imaging Biomarkers


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Liver Disease;Prevention;Rehabilitation;Substance Misuse

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Possible treatments for alcohol use disorder (AUD) include psychosocial therapies, Alcoholics Anonymous or similar 12-step programs, and pharmacotherapy, but only 20% of persons with lifetime AUD seek treatment of any kind. We propose to develop, validate, and apply a computer simulation model to estimate and compare the lifetime benefits of various AUD treatments and to augment an existing decision aid with such information to support shared decision-making. Results from this project will help to close the treatment gap by increasing their use, hence improving the medical care and quality of life for millions of Americans suffering from AUD.

PI_NAMEs: LE, PHUC  (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;acamprosate;Accounting;Acute;Adult;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol measurement;alcohol use disorder;Alcoholic Liver Diseases;Alcoholics Anonymous;Alcohols;American;American Psychiatric Association;Baclofen;Behavior Therapy;behavioral study;brief intervention;Calibration;Caring;Cessation of life;Chronic Disease;Cognitive Therapy;comparative effectiveness;compare effectiveness;Computer Simulation;cost;COVID-19 pandemic;Data;Decision Aid;Decision Modeling;design;Development;disease model;Disulfiram;drinking;drinking behavior;Effectiveness;Feedback;follow-up;gabapentin;Head;Health;Health Benefit;Heavy Drinking;improved;Injectable;innovation;Intervention;Interview;Life;Literature;Liver diseases;liver transplantation;Mathematical Model Simulation;Medical;Mission;Modeling;models and simulation;motivational enhancement therapy;Naltrexone;National Institute on Alcohol Abuse and Alcoholism;Natural History;optimal treatments;Oral;Organ;Outcome;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Policy Maker;Prevalence;prevent;programs;Provider;psychosocial;Public Health;Quality of life;Randomized, Controlled Trials;Recommendation;Recovery;Reporting;Research;Selection for Treatments;Severities;shared decision making;Structure;success;Support Groups;System;Time;tool;topiramate;treatment comparison;Treatment Effectiveness;trial comparing;United States Food and Drug Administration

PROJECT_TITLE: Using patient-level decision modeling to improve use of treatments for alcohol use disorder

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: SHAH, MANISH N (contact)

PROJECT_TERMS: Accident and Emergency department;Address;advanced dementia;Adverse event;Alzheimer's Disease;Applied Research;Area;Caring;Characteristics;Communication;Communities;Community Health;community intervention;community setting;Community Trial;cost;Dementia;dementia care;deprivation;design;Education;Effectiveness;Effectiveness of Interventions;effectiveness testing;Elderly;Emergency Care;Emergency Department patient;Emergency department visit;Emergency response;experience;Foundations;Funding;future implementation;Health;health care model;Health Planning Organizations;Health Services;Health system;Healthcare;Home;Home visitation;hospice environment;Hospitalization;Hospitals;Impaired cognition;implementation fidelity;implementation intervention;improved;indexing;innovation;Intervention;Intervention Studies;Lead;Managed Care Programs;Measures;Medical;member;Mental Depression;mortality;Nurses;older adult;Outcome;Paramedical Personnel;Patient Discharge;Patients;Persons;Population;Positioning Attribute;Pragmatic clinical trial;primary outcome;Provider;provider adoption;Publishing;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Resources;Risk;Role;screening;secondary outcome;Site;skills;social disparities;Structure;Symptoms;Telephone;Testing;United States;United States Centers for Medicare and Medicaid Services;Vaccination;Variant;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Community Paramedicine


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: TAMPA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative We propose a novel MD data analysis framework that can signiﬁcantly improve throughput and latency of data analysis tasks. It will also beneﬁt computer simulations as a high throughput means for researchers to study the structure, dynamics, and thermodynamics of biomolecules. This will greatly impact many ﬁelds of medical research such as discovery of new medicines, biomimetic material design, and pathology/diagnosis of genetic diseases.

PI_NAMEs: TU, YICHENG  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: ACE2;active control;Algorithms;analytical tool;big data management;Biological;Biological Models;Biological Process;Biomimetic Materials;cloud based;Collaborations;Communities;Computer Simulation;Computer software;computerized data processing;computing resources;cost;Data;Data Analyses;Data Analytics;data management;Data Management Resources;Data Set;Databases;design;Development;distributed data;Distributed Systems;Docking;drug-like compound;Genetic Diseases;genetic disorder diagnosis;glycosylation;Human;improved;Individual;Knowledge Discovery;large datasets;Letters;Location;Medical Research;Medicine;Methodology;Methods;Modeling;Modernization;Molecular;Molecular Analysis;molecular dynamics;molecular scale;Motion;Names;nano;novel;Online Systems;Outcome;Output;parallel computer;Pathology;Performance;Play;Process;programs;Proteins;Publishing;receptor;Research;Research Personnel;Resources;Role;Running;Sampling;SARS-CoV-2 infection;SARS-CoV-2 spike protein;simulation;simulation software;software systems;Stream;Structure;Structure-Activity Relationship;Supercomputing;System;Systems Analysis;task analysis;Techniques;Testing;Thermodynamics;Time;tool;tool development;Validation;wide area network;Work

PROJECT_TITLE: Data Management for Molecule Simulation : A Throughput-Oriented Approach

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


PHR: CORE 3 - NARRATIVE The Biostatistics Core is critical to the objectives of the P01 in order to ensure the proposed studies meet rigorous scientific standards. Successful translational of the pre-clinical models and human studies to patient care can be accomplished only if the results were statistically valid in terms of experimental design, data analysis and overall interpretation.

PI_NAMEs: YEAP, BEOW YONG  (contact)

PROJECT_TERMS: Biological Factors;Biological Markers;Biostatistics Core;Calibration;Cell Line;circulating biomarkers;Clinical;Code;Collaborations;Comparative Study;Consult;Consultations;cost;Data Analyses;data management;Data Set;Databases;Dedications;design;Development;Diagnosis;Discrimination;DNA Damage;dosimetry;Ensure;Experimental Designs;experimental study;Funding;Human;imaging biomarker;Lymphopenia;Measures;Mediation;Methodology;Modality;Modeling;novel;Output;Patient Care;Patient-Focused Outcomes;Patients;Performance;Photons;Pre-Clinical Model;predictive modeling;Process;Prognosis;Protons;Quality Control;Radiation;radiation effect;Radiation therapy;Reporting;Research;Research Design;Research Personnel;response;risk prediction model;Role;Sample Size;Specific qualifier value;Speed;symposium;tissue biomarkers;tool;translational cancer research;Validation

PROJECT_TITLE: Core 3: Biostatistics Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE  Key steps in vision include: (1) the absorption of light by the visual pigments of retinal rod and cone cells, which initiates a phototransduction cascade, and (2) the regeneration of these pigments by both enzymatic and light- dependent mechanisms. Although much has been learned about the chemistry and biology of these two pathways, fundamental questions remain unanswered. A more comprehensive understanding of these processes is essential to further delineate the etiology of human blinding diseases and consequently, to develop innovative therapeutic interventions that advance the practice of medicine.

PI_NAMEs: PALCZEWSKI, KRZYSZTOF  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 11 cis Retinal;absorption;Address;All-Trans-Retinol;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biology;Brain;Cattle;cell type;Cells;Cellular biology;Chemistry;chromophore;Cone;Coupled;Detection;Development;disabled;Disease;Electrophysiology (science);Elements;Enterobacteria phage P1 Cre recombinase;Environment;Enzymes;Etiology;Event;Excision;experimental study;G protein-coupled receptor RGR;G-Protein-Coupled Receptors;Generations;Genes;Genetic;Goals;GTP-Binding Proteins;Human;Hydrolysis;improved;In Vitro;in vivo;inhibitor;innovation;insight;Intervention;Isomerism;Knockout Mice;Learning;Lecithin;Light;light intensity;Link;Medicine;Metabolic;Methods;Microsomes;molecular modeling;mouse model;Muller's cell;Mus;mutant;Mutation;Natural regeneration;novel;novel therapeutic intervention;Opsin;Pathway interactions;Perception;pharmacologic;Photons;Photoreceptors;Phototransduction;Physiological;Physiology;Pigments;preservation;Process;Production;promoter;Proteins;quantum;Reaction;receptor expression;Receptor Signaling;Recombinants;Recovery;Regulation;Research;restoration;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal isomerase;Retinal Pigments;retinal rods;Retinaldehyde;Retinoids;Retinol dehydrogenase;retinol isomerase;Role;RPE65 protein;Signal Transduction;Signaling Molecule;Site;Source;Structure;Structure of retinal pigment epithelium;Terminator Codon;Testing;Therapeutic Intervention;Transferase;transmission process;Vertebrate Photoreceptors;Vision;Visual;visual cycle;visual information

PROJECT_TITLE: Retinoids in Vision

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative (Relevance) Cancer is a complex disease involving various molecular, cellular and immunological processes. In this project, we will perform advanced development and validation of composite gene delivery and CAR engineering systems. Our systems will enable broad applications in engineering of diverse cancer and immune cell types to accelerate cancer research and advance engineering of cellular immunotherapy against cancer.

PI_NAMEs: CHEN, SIDI  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;adeno-associated viral vector;Adopted;Adoptive Cell Transfers;Advanced Development;anti-cancer research;Benchmarking;Biomedical Engineering;CAR T cell therapy;Cell Physiology;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Chromosomal translocation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;CTLA4 gene;cytokine;Cytoplasmic Tail;design;Disease;Dissection;DNA;DNA Transposons;Electroporation;Elements;Engineering;exhaustion;Face;Functional disorder;Gene Delivery;gene delivery system;Gene Transduction Agent;Generations;genome editing;genomic aberrations;Genomics;genotoxicity;Hematopoietic Neoplasms;Immune;Immunologic Receptors;Immunologics;Immunology;Immunotherapeutic agent;improved;in vivo;Joints;knockout gene;Laboratory Research;Lentivirus Vector;Ligands;Malignant Neoplasms;Measures;Memory;Messenger RNA;Metabolic;Molecular;monomer;Nature;neoplastic cell;new technology;novel;Output;Pathway interactions;Patients;Performance;Process;programs;promoter;prototype;receptor;research and development;Retroviral Vector;Risk;Signal Transduction;Sleeping Beauty;Solid Neoplasm;success;System;T-Lymphocyte;Tail;Technology;technology development;technology validation;Therapeutic;therapeutic development;tool;Toxic effect;TP53 gene;transgene expression;Transposase;tumor;Tumor Antigens;Validation

PROJECT_TITLE: Advanced development of composite gene delivery and CAR engineering systems


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Human-centered design (HCD) is a paradigm for problem-solving that is gaining attention in the development of explainable artificial intelligence for clinical decision support, but implementation is hindered because it requires a multidisciplinary team of sociotechnical and clinical experts. Building on my unique background of over 10 years in clinical pediatric neuro-oncology and my previously published work and preliminary data in developing clinical artificial intelligence (AI), my proposal applies HCD methods to make usable clinical AI to improve clinical experts' ability to non-invasively diagnose pediatric suprasellar tumors. Upon completing this work, I will have the necessary multidisciplinary skill set to become an independent scientist focused on applying HCD to develop AI in pediatric neuro-oncology.

PI_NAMEs: PRINCE, ERIC W (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Academia;Adamantinomatous craniopharyngioma;Address;Adoption;Artificial Intelligence;artificial intelligence method;Attention;Bayesian Method;Brain Neoplasms;career;Childhood;Classification;Clinical;clinical application;clinical decision support;clinical decision-making;Clinical effectiveness;Clinical Medicine;Complex;complex data;computer science;Computer software;Consumption;cost;Data;Data Set;Decision Making;deep learning;deep learning model;design;Development;Diagnosis;Diagnostic;Diagnostic Errors;Empathy;experience;explainable artificial intelligence;Eye;Factor Analysis;Faculty;fictional works;Goals;Health Care Costs;Human;human centered design;Human Resources;improved;Industry;information seeking behavior;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Learning;Magnetic Resonance Imaging;Malignant Neoplasms;mathematical ability;Measures;Medical;Medicine;Mentors;Methods;Modeling;multidisciplinary;neuro-oncology;neurosurgery;noninvasive diagnosis;Oncology;open source;Operative Surgical Procedures;Outcome;Patient Care;Patients;pediatric suprasellar tumor;Performance;Persons;Positioning Attribute;pressure;Problem Solving;Process;prototype;Provider;Publishing;radiological imaging;Reporting;Research;Research Personnel;Resource Sharing;Role;satisfaction;Scientist;Self-Help Devices;Services;skills;Social Sciences;Stress;success;Surgical Pathology;Surveys;System;Technology;Testing;Therapeutic Intervention;Time;tool;Training;Translating;Translations;tumor;tumor diagnosis;Uncertainty;usability;Variant;Visualization;Work

PROJECT_TITLE: Human-centered design of clinical AI to support the diagnosis of pediatric suprasellar tumors


PHR: PROJECT NARRATIVE Aberrant transcriptional hub formation, defined by high local concentrations of proteins, has been associated with disease, including cancers and human expansion repeat disease, yet the exact functional consequence of hub formation remains unknown. Oncogenic mutations in the chromatin reader protein, ENL, are linked to transcriptional hub formation and are required for hyper-transcriptional activation of target genes. These mutations are a powerful system in which to understand hub-mediated transcription and the effect of hub formation the molecular kinetics of incorporated proteins, genome organization and alter transcriptional dynamics.

PI_NAMEs: MATHIAS, KAELI MARIE (contact)

PROJECT_TERMS: Acetylation;Affect;Behavior;Binding;Biological Assay;Biological Models;Cell Line;Cell Nucleus;Cells;cellular imaging;Chromatin;Complex;Defect;Development;Disease;DNA;DNA Polymerase II;Elements;Embryo;Engineering;Ensure;gain of function;GAS41 gene;Gene Activation;gene correction;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genome;Genomics;Goals;Health;Histone Acetylation;Human;human disease;Image;Imaging Techniques;in vivo;in vivo imaging;insight;interest;kidney cell;Kinetics;leukemia;Link;Malignant Neoplasms;Measurable;Mediating;Messenger RNA;Methods;MLLT3 gene;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular imaging;molecular scale;Monitor;Mutagenesis;mutant;Mutation;Nature;Nephroblastoma;novel;novel therapeutic intervention;Oncogenic;Organism;Outcome;Output;Pathogenicity;Pathologic;Pattern;Phosphorylation;Physical condensation;Positioning Attribute;Process;Production;Property;Protein Overexpression;Proteins;Proteomics;Reader;recruit;Regulation;residence;Resolution;RNA;Role;Series;single molecule;Site;Specificity;System;Techniques;Technology;Testing;Time;Transcription Elongation;Transcription Regulatory Protein;Transcriptional Activation;Transcriptional Regulation;Variant;virulence gene;Visualization;Work

PROJECT_TITLE: Mechanisms of pathogenic gene activation by aberrant transcriptional hubs formed by mutant ENL

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Sacrococcygeal teratomas arise from primordial germ cells (PGCs) and are the most common tumors in newborns and fetuses, causing significant perinatal morbidity and mortality and having a 35% rate of recurrence. This study aims to characterize, at the molecular level, the transition of PGCs to teratomas, understand the potential that apoptosis-resistance has on this transition, and to model this in vivo. These studies will identify the important developmental trajectories that occur with reversion from PGCs to pluripotency to tumor, improve insight to aid development of biomarkers for teratoma recurrences, and provide potential targetable pathways to treat the most aggressive tumors.

PI_NAMEs: ROJAS, ERNESTO JAVIER (contact)

PROJECT_TERMS: Apoptosis;Apoptotic;BAK1 gene;BAX gene;Bioinformatics;Biological Markers;Biological Process;Biology;biomarker development;Carcinogenicity Tests;Career Mobility;Cell Line;Cell model;Cell Transplantation;cell type;Cells;Cellular Assay;Chromatin;Clinical;clinical training;collaborative environment;Common Neoplasm;Complex;Development;Developmental Cell Biology;Doctor of Philosophy;Embryo;Environment;Ethics;experimental study;Exposure to;Failure;Fellowship;fetal;Fetus;Future;Gene Expression;Genetic Transcription;Germ cell tumor;Germ Cells;Germ Layers;Germ Lines;Goals;Gonadal structure;Growth Factor;Histology;Human;human induced pluripotent stem cells;human model;improved;in utero;In Vitro;in vitro Model;in vivo;in vivo Model;Infrastructure;Inhibition of Apoptosis;Injections;innovation;insight;Knowledge;Lead;Maintenance;Mediating;migration;Modeling;Molecular;molecular targeted therapies;Morbidity - disease rate;mortality;multiple omics;Mus;Names;Newborn Infant;Outcome;Pathway interactions;Patients;perinatal health;perinatal morbidity;Perinatal mortality demographics;perinatal period;pluripotency;Pluripotent Stem Cells;potential biomarker;Process;Proliferating;Recurrence;Research Training;Resistance;Risk;Role;sacrum;Sampling;Scientist;Signal Transduction;single-cell RNA sequencing;skills;stem cell biology;stem cells;Structure of primordial sex cell;Surgeon;Techniques;Technology;Teratoma;Testing;theories;therapy development;Tissues;Training;transcriptomics;transplant model;Transposase;tumor;tumor heterogeneity;tumorigenic;Tumorigenicity;Work

PROJECT_TITLE: Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Prevention

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Diseases of the colon are widespread, with colorectal cancer the 2nd leading cause of cancer death in the US and inflammatory bowel disease highly prevalent and rising in incidence across the globe. These pathologies have distinct presentations and outcomes across the length of the colon, but the genetic etiologies of these differences are poorly understood and limit precision treatment. By understanding how somatic mosaicism differs throughout the colon and disease development, we will be better equipped to treat these pathologies, better prepared to identify at-risk individuals, and better able to study tissue-specific disease progression in other organ systems.

PI_NAMEs: HIATT, LAUREL  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Adenocarcinoma;adenoma;Affect;Aging;Anatomy;Architecture;Benign;biobank;Biological;Biopsy;Body System;Cadaver;Cancer Etiology;causal variant;Cell Proliferation;Cells;Cessation of life;Clinical;cohort;Colon;colonic crypt;Colonic Diseases;Colonoscopy;Colorectal;Colorectal Cancer;Consensus;Detection;Development;Disease;Disease Management;Disease Progression;disorder risk;Dissection;early onset colorectal cancer;European ancestry;Event;fitness;Frequencies;gastrointestinal;Genetic Predisposition to Disease;genome sequencing;Germ Lines;Hindgut;human disease;human tissue;improved;Incidence;Individual;Inflammatory Bowel Diseases;innovation;insight;Institutional Review Boards;Investigation;Lasers;Left;Length;Link;Location;Malignant Neoplasms;Maps;Metadata;Methodology;microbiome;Midgut;Monitor;Morbidity - disease rate;mortality;mosaic;Mosaicism;Mutagenesis;Mutation;Mutation Analysis;Normal tissue morphology;Organ;Organism;Outcome;Pathogenesis;Pathologic Mutagenesis;Pathology;Patients;Pattern;Play;Polyps;Precision therapeutics;Predisposition;Reporting;Research;Resolution;Risk;Role;Sampling;screening;Somatic Mutation;Space Perception;spatiotemporal;Standardization;Structure;Syndrome;Testing;Tissues;Universities;Utah;Variant;whole genome

PROJECT_TITLE: SEMIColon: Somatic Exploration of Mosaicism in Colon


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

PI_NAMEs: WILLMAN, CHERYL LYNN (contact)

PROJECT_TERMS: Address;Agreement;American Indian community;American Indians;Arizona;Biometry;cancer genome;cancer survival;City of Hope Comprehensive Cancer Center;Clinical Research;Communication;Communities;community engagement;Complex;Comprehensive Cancer Center;computerized data processing;Data;Data Collection;data sharing;Development;Doctor of Philosophy;Epidemiology;Fostering;Genome;genome sequencing;Genomics;Goals;Grant;Guidelines;health disparity;Human Resources;Individual;Institution;Investments;Joints;Lead;Leadership;Medical Research;meetings;New Mexico;Participant;Pathology;patient engagement;Persons;Progress Reports;Reporting;Research;Research Institute;Role;Standardization;Strategic Planning;Strategic vision;Survival Rate;synergism;Tissue Sample;translational genomics;tribal community;tribal Nation;Tribes;Trust;United States;Universities;videoconference

PROJECT_TITLE: Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing - Administrative Core


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project could impact public health because it investigates B7-H3, a therapeutic target for neuroblastoma, for which immunotherapies have been developed and are in current or future clinical trials. This proposal aims to understand the mechanism by which B7-H3 is regulated, in addition to its functions as an oncoprotein. This research will help to meet the unmet need for the development of novel immunotherapeutic approaches in neuroblastoma while simultaneously furthering the translational research skills in an early career scientist.

PI_NAMEs: WINGROVE, CATHERINE LEONA-GRACE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 3-Dimensional;Adrenergic Agents;Adult;Antibody-drug conjugates;antigen-specific T cells;Antigens;Automobile Driving;Binding;Biological Assay;Biological Process;C57BL/6 Mouse;career;CD276 gene;CD3 Antigens;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cell secretion;Cell Surface Proteins;Characteristics;chemoradiation;Chemotherapy-Oncologic Procedure;Childhood;Childhood Extracranial Solid Tumor;chimeric antigen receptor T cells;ChIP-seq;Clinical Trials;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;comorbidity;Credentialing;CRISPR/Cas technology;cytokine;Cytolysis;cytotoxicity;Data;Dependence;Development;Diagnosis;differential expression;disorder risk;Effector Cell;Event;evidence base;Family;FDA approved;Fiber;Future;Genes;Genetic;Genetic Transcription;Growth;high risk;Human;Human Cell Line;Immune;Immune Evasion;Immunocompetent;immunodeficiency;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In Vitro;in vivo;Inflammatory;inhibitor;Integral Membrane Protein;Interferons;Interleukin-2;International;Invaded;knock-down;Life;Ligands;Luciferases;Malignant Childhood Neoplasm;Malignant Neoplasms;MART-1 Tumor Antigen;Mediating;Mediator;Mesenchymal;migration;Migration Assay;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;mouse model;Mutate;Mutation;MYCN gene;National Research Service Awards;Natural Killer Cell Immunotherapy;Natural Killer Cells;Neoplasm Metastasis;Neuroblastoma;neuroblastoma cell;new therapeutic target;novel;novel therapeutics;Oncogenes;Oncogenic;Oncoproteins;Operative Surgical Procedures;overexpression;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;pre-clinical;Proliferating;promoter;Proteins;Proto-Oncogene Proteins c-myc;Public Health;Radiation;Recombinants;Research;research clinical testing;Resistance;response;Role;Scientist;Seminal;side effect;skills;Solid;Solid Neoplasm;spheroids;success;Survival Rate;Survivors;Sympathetic Nervous System;System;T cell response;T-Cell Activation;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;Testing;therapeutic target;TNF gene;Toxic effect;transcription factor;Transforming Growth Factor beta;Transgenic Organisms;Translational Research;Treatment Protocols;treatment strategy;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Work;wound;Xenograft procedure

PROJECT_TITLE: Defining the mechanisms of B7-H3 overexpression and role in neuroblastoma metastasis and immune evasion


ORG_CITY: DAVIS

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Imbalanced protein homeostasis (proteostasis) disrupts protein clearance and increases abnormal deposition of protein aggregates which facilitates cancer cell survival and progression. Ubiquitin mediated proteolysis pathway and proteasome activity are suppressed in next generation anti-androgen resistant prostate cancer cells which results in stabilized androgen receptor variant protein in these resistant cells through Hsp70/Stub1 machinery. This proposal will provide new insights into the role of chaperone- ubiquitin-proteasome alteration in advanced prostate cancer and devise the strategies to overcome the therapeutic resistance.

PI_NAMEs: LIU, CHENGFEI  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: abiraterone;Acetates;advanced prostate cancer;Androgen Antagonists;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Anti-androgen Therapy;Antibodies;Automobile Driving;Binding Sites;Biochemical;Biological Assay;Bone marrow biopsy;Calorimetry;cancer cell;cancer drug resistance;Cancer Etiology;Cancer Patient;cancer recurrence;Cell Culture Techniques;Cell Survival;Cells;Cessation of life;Chronic;clinically relevant;Co-Immunoprecipitations;Complex;Data;Deposition;Diagnosis;Disease;Drug resistance;Drug Sensitization;effective therapy;effectiveness testing;efficacy testing;enzalutamide;Evolution;Flow Cytometry;Genes;Gleason Grade for Prostate Cancer;Glucocorticoid Receptor;Goals;Human;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;inhibitor;insight;Label;Length;Ligation;Longevity;Lysine;Malignant neoplasm of prostate;Mass Spectrum Analysis;Mediating;men;Molecular Chaperones;multicatalytic endopeptidase complex;Neoadjuvant Therapy;next generation;novel;novel strategies;Oncogenic;Outcome;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Play;Population;Precipitation;Primary Neoplasm;programs;prostate cancer cell;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;protein aggregation;Proteins;proteostasis;proteostasis loss;Radiation;Radical Prostatectomy;receptor expression;Reporting;Resistance;Resistance development;resistance mechanism;Role;small molecule;small molecule inhibitor;Specimen;Stains;success;System;targeted treatment;Technology;Testing;Therapeutic;therapy resistant;Time;Tissue Microarray;Titrations;Treatment outcome;tumor;tumor growth;tumor progression;tumorigenesis;Ubiquitin;Ubiquitin-mediated Proteolysis Pathway;ubiquitin-protein ligase;Ubiquitination;United States;Variant

PROJECT_TITLE: Dissecting the Role of Proteostasis in Anti-Androgen Resistant Prostate Cancer

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PI_NAMEs: GEREAU, ROBERT W (contact)

PROJECT_TERMS: Agreement;Area;Automobile Driving;axon regeneration;axonal degeneration;Biological Assay;Cells;Collaborations;Collection;Communication;Compensation;Continuing Education;Core Facility;Data;Data Collection;data harmonization;Dedications;Development;Education;experience;Faculty;Feedback;Genetic;Genetic Transcription;Genome;Genomics;Human;Human Resources;human tissue;improved;Institution;Internships;Knowledge;lecturer;lectures;Manuscripts;Mediation;Medical Students;Medicine;meetings;member;Metadata;Neurobiology;Outcome;Pain;Pain Research;Patients;Positioning Attribute;Preparation;Program Reviews;programs;Progress Reports;Property;Protocols documentation;Published Comment;Quality Control;recruit;Reporting;Reproducibility;Research;Research Personnel;Resource Allocation;Science;Senior Scientist;Series;Specimen;Standardization;Students;summer research;summer student;symposium;synergism;Time;tissue processing;Tissue Procurements;Tissues;transmission process;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Update;Validation;Visit;Washington;Work

PROJECT_TITLE: Core A: Administration


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: RENO

ORG_NAME: STRYKAGEN CORPORATION

ORG_STATE: NV

PHR: Project Narrative Duchenne Muscular Dystrophy (DMD) is a fatal muscle disease with a predicted incidence of 1 in 5000 males. In this Phase 2B SBIR proposal, StrykaGen in collaboration with the Nghiem lab at the Texas A&M University, propose to perform critical preclinical and GRMD dog efficacy studies using our lead α7 integrin enhancing small molecule called Stryka969. Results from this study will move Stryka969 towards IND and clinical trials as a therapeutic option for patients with DMD.

PI_NAMEs: WUEBBLES, RYAN DAVID (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Actins;Adrenal Cortex Hormones;Adult;Adverse event;Affect;Animal Model;Animals;Becker Muscular Dystrophy;Binding;Birth;canine model;Canis familiaris;Cardiac;Clinical Trials;Collaborations;Compensation;Complex;Cyclic GMP;Cytoskeleton;Development;Disease Progression;Dose;Drug Industry;Drug Kinetics;Drug Targeting;Duchenne muscular dystrophy;Dystrophin;Effectiveness;efficacy evaluation;efficacy study;Evaluation;exon skipping;exon skipping therapy;Extracellular Matrix;FDA approved;Future;Gene Mutation;gene therapy;Genes;Glycoproteins;Heart Diseases;heart function;heart imaging;Histologic;Homologous Gene;Human;Human Engineering;improved;Incidence;Integrins;Investments;ITGA7 gene;Laminin;Lead;Link;Macaca fascicularis;male;manufacture;mdx mouse;Measurement;Mechanics;Mediating;Medical;meetings;Membrane;micro-dystrophin;Molecular;mouse model;Mus;Muscle;muscle degeneration;Muscle Fibers;Muscle function;muscle regeneration;muscle strength;Muscular Atrophy;Muscular Dystrophies;Mutation;Myocardium;Myopathy;neuromuscular;nonhuman primate;Organ;Outcome Measure;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Physiological;pre-clinical;pre-clinical assessment;Pre-Clinical Model;pre-Investigational New Drug meeting;Preclinical Drug Development;protein complex;Proteins;Regenerative capacity;Research Design;Safety;Sarcolemma;Scaffolding Protein;Serum;Signal Transduction;skeletal disorder;Skeletal Muscle;Small Business Innovation Research Grant;Small Business Technology Transfer Research;small molecule;SSPN gene;Symptoms;System;Technology;Texas;Therapeutic;Tissues;Toxic effect;Transgenic Organisms;Treatment Efficacy;Universities;Utrophin;Viral;Wasting Syndrome;X Chromosome

PROJECT_TITLE: Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Clinical Research;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Precision Medicine

PI_NAMEs: MILBRANDT, JEFFREY D (contact)

PROJECT_TERMS: abuse liability;Address;afferent nerve;American;Atlases;Axon;axonal sprouting;Candidate Disease Gene;candidate validation;Cell Nucleus;cell type;Cells;Chromatin;chronic pain;chronic painful condition;Clinical;cohort;Communities;Cutaneous;Data;data integration;Data Set;Disease;experimental study;Failure;Femur;Foundations;Functional disorder;Gene Combinations;gene discovery;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genetic variant;Genome;genome analysis;genome sequencing;Genomic approach;Genomics;Genotype;Goals;Grain;Human;Immune;insight;Knowledge;Lateral;Macrophage;Maps;Medical;Methods;Molecular;molecular phenotype;Motor;multiple omics;Mus;Mutation;Nerve;Neuroglia;Neurologic;Neuroma;neuron component;Neurons;Nociceptors;novel;novel therapeutics;Ontology;Operative Surgical Procedures;opioid overuse;Organ Donor;Pain;Pain Map;pain model;painful neuropathy;Pathway Analysis;Pathway interactions;patient stratification;Patients;Pattern;Peripheral Nerves;Peripheral Nervous System;peripheral pain;Phenotype;pre-clinical;Pre-Clinical Model;Proteomics;Research;Resected;Resolution;Resources;response;risk variant;RNA;Rodent;Sampling;Schwann Cells;Sensory;Series;single nucleus RNA-sequencing;Statistical Data Interpretation;Syndrome;Technology;Therapeutic;Tissue Donors;Tissue Procurements;Tissues;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Traumatic injury;Variant;whole genome;XCL1 gene

PROJECT_TITLE: Multi-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypes