ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE This study is highly relevant for public health because it will improve the available disease models used for drug discovery and biological research by improving cell models' capabilities made with Induced Pluripotent Stem Cells. The new technology will leverage CRISPR technology to modify these cells to add multiple color proteins genetically, which will allow live-cell visualization of the effects of novel drugs or pathological processes on affected cell structures.

PI_NAMEs: PEREZ, OSCAR  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Affect;biological research;cancer cell;Cancer cell line;Cell Differentiation Induction;Cell Differentiation process;cell fixing;Cell Line;Cell membrane;Cell model;Cell Nucleus;Cells;Cellular biology;Cellular Structures;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Color;Confocal Microscopy;CRISPR/Cas technology;Cytoskeleton;Data;Development;Disease;disease model;DNA;drug candidate;drug discovery;Drug Screening;Drug Targeting;Drug usage;Endoplasmic Reticulum;Failure;Gene Modified;Generations;Genes;Genetic;Genetic Transcription;genetically modified cells;Genome;genome editing;Genomics;Hela Cells;improved;induced pluripotent stem cell;interest;Investigational Drugs;Label;Legal patent;Libraries;Mammalian Cell;Methodology;Methods;Microscopic;Mitochondria;Modeling;Modification;mutation correction;new technology;novel;novel therapeutics;Organelles;Pathologic Processes;patient derived induced pluripotent stem cells;Plasmid Cloning Vector;Plasmids;pre-clinical;prevent;Process;Proteins;Public Health;Reagent;Reporter;Research Personnel;Scientist;Stains;stem cells;success;System;Techniques;Technology;Testing;Therapeutic;Time;tool;Validation;vector;Vertebral column;Visualization;Work

PROJECT_TITLE: CRISPR-based genome tagging of iPS Cells for stain-free multicolor live cell analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(54)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Mental Health;Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative  Aggression, in most cases, is an adaptive behavior but in humans some forms of aggression are considered pathological when they threaten lives and/or increase the risk of psychiatric impairment in victims. Past research suggests that highly aggressive individuals have a perceptual bias which impairs their ability to act appropriately in social contexts. This project will examine how the posterior cortical amygdala affects social perception and aggression in an outbred strain of mice.

PI_NAMEs: AUBRY, ANTONIO V (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Adaptive Behaviors;Affect;Aggressive behavior;Amygdaloid structure;Anger;Animals;Anogenital region;Axon;Behavior;Behavior Control;Behavioral;behavioral response;Brain region;cell type;Cells;Child Rearing;Complex;Corpus striatum structure;Cues;Data;diencephalon;Economic Burden;Ensure;ESR1 gene;Exhibits;Face;Female;Fiber;Fire - disasters;Food;Globus Pallidus;Home;Human;Hypothalamic structure;Image;Impairment;in vivo;Individual;Individual Differences;Investigation;Lateral;Learning;Link;male;Mediating;Mental disorders;Modeling;Motivation;motivational processes;Mouse Strains;Mus;neuromechanism;nonhuman primate;Odors;olfactory bulb;olfactory stimulus;optogenetics;Partner in relationship;Pathologic;Perception;Perforation;Phase;Photometry;Play;Population;prevent;Process;programs;Research;Research Personnel;Resources;response;Risk;Rodent;Role;Self Administration;Sensory;sensory input;Signal Transduction;Slice;Smell Perception;social;Social Behavior;Social Environment;Social Hierarchy;Social Perception;Social Protection;Societies;Stimulus;Structure;System;Testing;Training;Ventral Striatum;Vision;Visual System;Whole-Cell Recordings;Work

PROJECT_TITLE: Functions of the Cortical Amygdala in social behavior


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Nutrition;Obesity

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The changing food environment, with increasingly abundant ultra-processed food (UPF) options, may directly contribute to rising rates of obesity, though it is unknown which ingredients in UPF elevate their reinforcing nature in a way that may lead to overconsumption. The proposed study is the first to systematically examine differences in the rewarding characteristics of and physiological and metabolic responses to UPFs that are high in fat, refined carbohydrates (like sugar), or both. Understanding the biobehavioral underpinnings that enhance the reinforcing potential of ingredients in UPF (e.g., fat vs. refined carbohydrates) can inform novel intervention targets for the treatment of overeating and obesity.

PI_NAMEs: LAFATA, ERICA M (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TITLE: Biobehavioral Reward Responses Associated with Consumption of Nutritionally Diverse Ultra-Processed Foods

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK(M1)-1-C]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Genetics;Hearing Loss;Neurosciences;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative  There is growing awareness of the importance of sex differences in the auditory system, particularly susceptibility to otological disorders. The proposed study will determine molecular mechanisms for female hearing loss. This study is relevant to public health because the knowledge gained from the studies will guide future clinical efforts to develop diagnostic tools for defining underlying causes of female hearing loss.

PI_NAMEs: HU, BO HUA  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;age related;Alleles;Auditory;Auditory system;Autoimmune Diseases;Awareness;beta-galactoside;Binding Proteins;Biological;Biological Markers;Biological Process;Cells;Clinical;clinical application;Clinical Research;clinical translation;clinically relevant;Cochlea;Code;Congenic Mice;Data;Development;diagnostic development;diagnostic tool;Disease;Ear;experience;experimental study;Female;Foundations;Frequencies;Future;Galectin 3;Gene Expression;Genes;Genetic;Goals;Gonadal Steroid Hormones;Hearing;hearing impairment;hearing loss treatment;Hearing problem;High Prevalence;Homeostasis;hormone regulation;Hormones;Human;Immune;immune activation;immune function;Immunocompetent;immunoregulation;Inflammatory;Inflammatory Response;inner ear diseases;Knock-out;Knowledge;Lectin;Link;Macrophage;male;Mediating;middle age;Molecular;Mouse Strains;Mutation;Noise-Induced Hearing Loss;novel;Otology;Pathogenesis;Pilot Projects;Postmenopause;Predisposition;Presbycusis;Prevalence;prevent;Production;Protein Family;Proteins;Public Health;Research;response;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;sex linked trait;Speech;Stress;Supporting Cell;Testing;Therapeutic;tool;Woman

PROJECT_TITLE: Novel mechanism for sex differences in hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: PROJECT NARRATIVE In the U.S., the childhood obesity epidemic disproportionally impacts minority communities, particularly Hispanic children. Minority populations face multiple psychosocial stressors at the individual, household and community level that are associated with increased obesity risk. This research will establish the biological embedment of early-life adversity at the individual, household and community level on epigenetic marks, with the goal of developing early-life biomarkers of risk.

PI_NAMEs: CARDENAS, ANDRES ;DEARDORFF, JULIANNA  (contact)

PROGRAM_OFFICER_NAME: MUNIZ ORTIZ, JORGE GERARDO

PROJECT_TERMS: 14 year old;18 year old;accelerated epigenetic aging;Acceleration;Address;Adolescence;Affect;Age;Aging;aging biomarker;aging clocks;Biological;biological adaptation to stress;Biological Markers;Biological Testing;Birth;Blood;California;Candidate Disease Gene;Cell Differentiation process;Cell Lineage;Cellular Structures;Child;Childhood;Chronic;cohort;Communities;Cues;Data;Development;Disease;DNA Markers;DNA Methylation;early childhood;early detection biomarkers;early life adversity;Embryonic Development;Environment;Epidemic;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;epigenomics;Exposure to;Face;fetal;Fetal Development;Future;Gene Expression;Genes;Genetic;Genotype;Goals;Health;health assessment;health disparity;Hispanic;Household;Immune system;Individual;Inflammatory;Latinx;Life;Longitudinal Studies;Low income;machine learning method;Measurement;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Metabolic;Methods;Methylation;methylation biomarker;methylation pattern;methylome;Mexican Americans;Minority;minority communities;Minority Groups;Modeling;Morbidity - disease rate;Mothers;Not Hispanic or Latino;novel;Obesity;Obesity Epidemic;obesity in children;obesity risk;offspring;Overweight;Pathway interactions;Pattern;Phase;Physiological;postnatal;postnatal period;Predisposition;prenatal;prenatal influence;prenatal testing;Prevalence;programs;prospective;Psychosocial Factor;psychosocial stressors;Public Health;racial disparity;rate of aging;Reporting;Research;response;Risk;Risk Factors;Role;Salinas Valley;Sampling;social;social adversity;Social Environment;Statistical Methods;stressor;Testing;Tissues;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Variant;Writing

PROJECT_TITLE: Common and Distinct Influences of Prenatal and Postnatal Early-Life Adversity on Epigenomic Trajectories in Mexican American Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE SARS-CoV-2 infection of human cells requires a number of activated human cellular pathways for successful replication. Inhibition of the human mitogen-activated protein kinase (MAPK) pathway blocks SARS-CoV-2 replication, suggesting that MAPK pathway activation is required for viral replication. This project aims to understand how additional MAPK pathways benefit SARS-CoV-2 replication to identify novel drug targets that may be developed for COVID-19 treatment.

PI_NAMEs: JOHNSON, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Affect;Animals;Anti-viral Therapy;Area;base editing;Bioinformatics;Cells;Cessation of life;Chemicals;Combined Modality Therapy;COVID-19 pandemic;COVID-19 treatment;CRISPR/Cas technology;cytokine;Dependence;Disease;Disease Outcome;Drug Targeting;Effectiveness;Family;Generations;Genetic;Genetic Screening;Genome;Human;human stem cell-derived;Immune;Immune response;in vivo;Infection;Infiltration;Inflammation;Inflammatory;interdisciplinary approach;Interleukin-6;Lung;Measures;Mediating;Methods;Mitogen-Activated Protein Kinase Inhibitor;Mitogen-Activated Protein Kinases;Modeling;Modification;Molecular;mouse model;Multiple Organ Failure;Mutate;Mutation;new therapeutic target;Nucleoproteins;nucleoside analog;Organoids;p38 Mitogen Activated Protein Kinase;Pathogenicity;Pathway interactions;Paxlovid;Phenotype;phosphoproteomics;Phosphorylation Site;Phosphotransferases;Play;Predisposition;prevent;Production;Protease Inhibitor;Proteins;Proteome;Proteomics;recombinant virus;Recombinants;Regulation;remdesivir;Research;Respiratory Failure;respiratory infection virus;response;Role;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;severe COVID-19;Signal Transduction;Small Interfering RNA;small molecule;stem cell organoids;Technology;Testing;tool;Vaccines;Viral;Viral Proteins;Virus Replication;Work

PROJECT_TITLE: Function interactions between mitogen-activated protein kinases (MAPKs) and SARS-CoV-2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-S(90)]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Racial and Ethnic Minority Health Research;Rehabilitation;Serious Mental Illness;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Latinx adolescents experience a higher prevalence of depressive symptoms and are less likely to receive treatment for depression than their non-Latinx White peers. Evidence-based treatments for adolescent depression exist, but Latinx adolescents face both universal and culture-specific barriers to receiving these treatments. The proposed study seeks to develop and test culturally-sensitive patient- and family-focused implementation strategies that will improve initiation of and retention in evidence-based psychotherapy for depression among Latinx adolescents.

PI_NAMEs: STAFFORD, ALLISON MCCORD (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Adolescent;Adoption;anti-depressive agents;arm;Award;Behavior;behavioral health;Belief;care seeking;career;Caregivers;Caring;child depression;Clinical;Clinical Trials;Clinical Trials Design;Cognitive Therapy;community advisory board;Data;Depressive disorder;depressive symptoms;design;Development;Diagnosis;Disparity;Drops;Educational workshop;Electronic Health Record;ethnic minority population;evidence base;Evidence based intervention;Evidence based treatment;experience;Face;Family;Feedback;Female;Focus Groups;follow-up;Foundations;Fright;Gender;Goals;Growth;Health;health disparity;health equity;Health Personnel;Health Professional;High Prevalence;Hispanic;Immigrant;Immigrant family;implementation evaluation;implementation outcomes;implementation process;implementation science;implementation strategy;improved;innovation;interpersonal therapy;Interview;Judgment;Latina;Latino;Latinx;Latinx population;Linguistics;Major Depressive Disorder;male;Male Adolescents;Measurement;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;Methods;Modeling;North Carolina;Outcome;Parents;patient oriented;Patient Self-Report;Patients;peer;peer support;Perception;Pharmaceutical Preparations;pilot trial;preference;premature;prevent;primary care clinic;programs;Psychotherapy;Qualitative Research;Randomized;Randomized, Controlled Trials;recruit;Research;Research Personnel;Sampling;Schedule;Series;Services;substance use;suicidal;Surveys;Teenagers;Testing;Thinking;Time;Training;treatment as usual;Treatment Efficacy;treatment trial;Visit;Youth

PROJECT_TITLE: Refinement and Testing of Implementation Strategies to Promote Psychotherapy Attendance for Depression among Latinx Teens


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: NARRATIVE Corticogeniculate circuits are in a unique position to regulate the feedforward flow of visual signals traveling from the retina to the cortex, however little is known about how corticogeniculate circuits contribute to vision. In the last grant period, we provided groundbreaking new evidence showing that corticogeniculate feedback to the visual thalamus controls the timing and precision of thalamic responses to incoming visual inputs. Building upon these findings, we apply intersecting and emerging technologies such as functional ultrasound imaging, optogenetics, chemogenetics, and neurophysiological recordings to understand the connectivity and function of corticogeniculate circuits in vision. Results of this study will further our understanding of how the brain prioritizes sensory signals arriving from the environment and could contribute to better understanding of disruptions in sensory perception observed in neurological disorders such as Autism Spectrum Disorder.

PI_NAMEs: SNYDER, ADAM CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Anesthesia procedures;Animals;area striata;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;Brain;color processing;corticogeniculate;density;design;Diffuse;Dorsal;Emerging Technologies;Environment;experimental study;Feedback;Ferrets;Gene Delivery;Genetic;Goals;Grant;improved;Individual;Infection;insight;Knowledge;koniocellular;Lateral Geniculate Body;Link;Macaca;magnocellular;Mammals;Maps;Measures;Mediating;Modality;Monkeys;Morphology;Motion;Motivation;multi-electrode arrays;Nervous System Disorder;Neurons;neurophysiology;Neurosciences;novel;novel virus;optogenetics;parallel processing;parvocellular;Pathway interactions;Perception;Peripheral;Phase;Physiological;Population;Positioning Attribute;preference;Primates;Property;Proteins;receptive field;response;Response Latencies;Retina;retinal axon;Role;Sensory;sensory cortex;sensory system;Signal Transduction;Stimulus;Stream;Synapses;Testing;Thalamic structure;transmission process;Travel;Ultrasonography;ultrasound;Vision;Visual;Visual Cortex;visual discrimination;visual information;Visual Perception;visual stimulus;Visual System;Work

PROJECT_TITLE: The functional role of corticogeniculate feedback in vision

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: We have preliminarily found a profound inhibitory effect of systemic L-serine supplementation on retinal neovascularization in mouse OIR modeling ROP. We will further examine the role of L-serine in retinal neovascularization in OIR, and whether retinal glia contribute to this process. Little work has been done in this area.

PI_NAMEs: FU, ZHONGJIE  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adverse effects;Affect;Amino Acids;Angiogenic Factor;Angiopoietin-2;Area;Attenuated;Birth;Blindness;Blood Vessels;Bronchopulmonary Dysplasia;Cells;Child;Citric Acid Cycle;Development;Disease;Dose;early satiety;Enzymes;extreme prematurity;Fertilization in Vitro;Food;Genetic Transcription;Gestational Age;GLAST Protein;Glial Fibrillary Acidic Protein;Growth;high risk;Hypoxia Inducible Factor;improved;in utero;In Vitro;in vivo;Incidence;Intervention;intraventricular hemorrhage;Knock-out;Knowledge;laser photocoagulation;Life;LoxP-flanked allele;Mediating;Metabolic;Mitochondria;Modeling;mouse model;Mus;Mutation;neovascular;neovascularization;Neuroglia;neurosensory;Nutrient;Oral;Organ;Oxygen;Pathogenesis;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phase;Phosphoglycerate dehydrogenase;postnatal;Premature Birth;Premature Infant;prevent;Prevention;Process;Rattus;Regulatory Pathway;response;Retina;retina blood vessel structure;Retinal Diseases;Retinal Neovascularization;Retinopathy of Prematurity;Risk;Role;Serine;Serum;Source;supplemental oxygen;Supplementation;Tamoxifen;TNF gene;transcriptomics;Vascular Endothelial Growth Factors;Viral Vector;Weight Gain;Western Blotting;Work

PROJECT_TITLE: Serine control of retinal neovascularization in retinopathy

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Rural Health;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Rural residents experience substantial barriers in accessing healthy foods, but may also be exposed to other hazards of their local food environment through chemical contaminants ingested from dietary sources. This study will perform geographically detailed surveillance in rural Sullivan County, New York to identify how diet quality and dietary contaminants may interact to increase diabetes risk in rural communities. Findings will inform strategies to improve dietary behavior, reduce dietary chemical exposures, and prevent diabetes among rural residents.

PI_NAMEs: LEE, DAVID C (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Accounting;Address;Affect;Area;Behavior;bisphenol A;Canned Foods;Carbohydrates;Cessation of life;Characteristics;Chemical Exposure;Chemicals;clinically significant;Collaborations;cost;County;Cross-Sectional Studies;Data;Diabetes Mellitus;diabetes risk;diabetic;Diagnosis;Diet;dietary;Disparity;Eating;Economics;Endocrine Disruptors;Environmental Exposure;Ethnic Origin;experience;Exposure to;Face;fast food;Fatty acid glycerol esters;Food;Food Access;Food Analysis;food consumption;food environment;Food Packaging;Food Supply;Foundations;Frequencies;geographic barrier;geographic difference;geographic disparity;Geographic Locations;Geography;glycemic control;Glycosylated hemoglobin A;Goals;hazard;Health;Health Food;Healthy Eating;high risk;Household;improved;Income;indexing;Ingestion;Insulin Resistance;Intake;Intervention;Joints;Label;Life;Macronutrients Nutrition;Measures;Modeling;mortality;New York;Outcome;Pattern;phthalates;point of care;Population;population based;Poverty;premature;Prevalence;prevent;Process;Public Health;Questionnaires;Race;Research;response;Risk;Risk Factors;Rural;rural area;Rural Community;rural counties;rural dwellers;Rural Population;rural setting;Sampling;Socioeconomic Factors;Source;Surveys;Testing;Unhealthy Diet;urban area;urinary

PROJECT_TITLE: The Impact of the Food Environment and Other Environmental Exposures on the Risk of Diabetes in Rural Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Narrative A growing body of evidence indicates that environmental information can be inherited, which suggests that changes in the mammalian germline can act as a trans-generational carrier of environmental information. Here, we describe a rat model developed in order to delineate heritable behavioral characteristics resulting from paternal self-administration of the psychostimulants cocaine and methamphetamine. The experiments described in this application will use state-of-the-art molecular and behavioral methodologies to examine epigenetic mechanisms whereby psychostimulant-associated information can be transmitted from sires to offspring and grand-offspring.

PI_NAMEs: PIERCE, ROBERT CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Adult;Animal Model;Anxiety;ATAC-seq;Behavior;behavior influence;Behavioral;bisulfite sequencing;Brain;Brain region;Breeding;Cell Nucleus;Characteristics;Chromatin;Cocaine;cocaine exposure;cocaine self-administration;Coupling;Data;design;DNA Methylation;Epigenetic Process;epigenome;experimental study;Female;Funding;Gene Expression;Gene Expression Profile;Generations;Genes;genome-wide;Germ Lines;Grant;Health;Heritability;Hippocampus;Human;Impairment;Inherited;interest;knock-down;Learning;Maintenance;male;Measurement;Mediating;Messenger RNA;Methamphetamine;methamphetamine exposure;Methodology;Methylation;MicroRNAs;Modeling;Molecular;Motivation;N-Methyl-D-Aspartate Receptors;Neurons;new therapeutic target;novel;novel strategies;Nucleus Accumbens;offspring;overexpression;Partner in relationship;Paternal Exposure;Pharmaceutical Preparations;Phenotype;Physiology;Play;programs;protective factors;Proteins;psychostimulant;Rattus;Receptor Signaling;Reinforcement Schedule;reinforcer;Research;Resistance;Risk Factors;RNA methylation;Role;Saline;Self Administration;Serine;sex;single nucleus RNA-sequencing;Specificity;sperm cell;stimulant dependence;Sucrose;Synaptic plasticity;targeted treatment;therapeutic development;Transcript;transcriptome sequencing;Transfer RNA;transgenerational epigenetic inheritance;transmission process;United States National Institutes of Health;Untranslated RNA;Viral;Work

PROJECT_TITLE: Transgenerational Inheritance of a Cocaine Resistance Phenotype

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Blood-brain barrier disruption is a critical component in the pathology of stroke and contributes significantly to the poor clinical outcome. The proposed study will investigate the epigenetic mechanisms that contribute to an intact BBB and target these mechanisms to repair leaky BBB after stroke. If successful this therapeutic strategy targeting the BBB repair would be clinically relevant for patients suffering from several common neurological conditions.

PI_NAMEs: THANKAMANI PANDIT, PEEYUSH KUMAR (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Adult;Agonist;angiogenesis;beta catenin;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;brain endothelial cell;Cellular biology;Central Nervous System;Central Nervous System Diseases;Cerebral endothelium;cerebrovascular;Cerebrum;Classification;Clinical;Clinical Trials;clinically relevant;Complex;Data;Development;Disease;effective intervention;Embryo;Endothelial Cells;Enzymes;Epigenetic Process;epigenetic silencing;Evaluation;experimental study;functional loss;functional outcomes;Gene Expression;Gene Expression Profile;gene repression;Gene Silencing;Genes;Genetic Transcription;Genome;Goals;histone deacetylase 2;Histone Deacetylation;Impairment;improved;improved outcome;inhibitor;Injury;insight;Interdisciplinary Study;Knowledge;Ligands;Measures;Mediating;Modeling;Natural regeneration;Neurologic;Neuronal Injury;neuroprotection;new therapeutic target;novel;novel therapeutics;Outcome;Pathology;Pathway interactions;Patients;Pattern;pharmacologic;Phenotype;Polycomb;post stroke;prevent;programs;Recovery;Rejuvenation;repaired;reparative capacity;Repression;Research;Role;Signal Pathway;Stroke;stroke model;stroke patient;stroke therapy;targeted treatment;Testing;Therapeutic;Time;Tracer;transcription factor;transcriptome;transcriptome sequencing;translational potential;vascular factor;Vascular regeneration

PROJECT_TITLE: Endothelial Cell Epigenetics and Blood-Brain Barrier.


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Acetaminophen (APAP) exposures are ubiquitous use during pregnancy and early life during lung development. Alarmingly, clinical data support the hypothesis that the developing lung may be adversely affected by APAP exposure due to the developmental ontogeny of pulmonary CYP2E1 expression. These pre- clinical studies will be the first to interrogate the mechanisms underlying the unique susceptibility of the developing lung to APAP exposure and help determine its safety profile in this understudied population.

PI_NAMEs: WRIGHT, CLYDE JASON (contact)

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Acetaminophen;Acute;Adult;Adverse effects;Affect;Alveolar;Analgesics;Attenuated;Biology;Bronchopulmonary Dysplasia;Cell Death;cell type;Cells;Childhood;Clinical;Clinical Data;clinically relevant;CYP2E1 gene;Data;Development;drug action;Enzymes;experimental study;Exposure to;fetal;Fetal Lung;Funding Opportunities;gain of function;genetic approach;Growth;Hepatic;hepatocellular injury;Hepatocyte;Hepatotoxicity;Human Development;Hyperoxia;Imines;immune activation;Immune signaling;Immunology;improved;in utero;in vivo;Injury;Knowledge;Life;Link;Liver;loss of function;Lung;lung development;lung injury;maternal safety;Mediating;medication safety;Metabolic stress;Metabolism;Mitochondria;Mitochondrial DNA;Mus;Myofibroblast;Neonatal;neonatal exposure;Neonatal Intensive Care Units;Neonatal lung;neonatal lung injury;Newborn Infant;novel;opioid exposure;Outcome;Oxidative Stress;para-benzoquinone;Patent Ductus Arteriosus;Pathway interactions;Perception;Perinatal;Perinatal Exposure;pharmacologic;Physiology;Placenta;Population;Positioning Attribute;postnatal;pre-clinical;preclinical development;preclinical study;Predisposition;Pregnancy;pregnant;prenatal;preterm newborn;receptor;Reporting;respiratory morbidity;response;Risk;Safety;Signal Transduction;Slice;Stress;stressor;Structural defect;Structure;Testing;therapeutic target;Toxic effect;Toxin;Xenobiotics

PROJECT_TITLE: Pulmonary implications of perinatal acetaminophen exposure


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The blueprint of embryonic development is encoded in an organism's genome, and access to these instructions is regulated by epigenetic systems. While much of the research on embryonic development has focused on the nature of the instructions themselves, less is understood about the epigenetic mechanisms that determine where and when such instructions are carried out. The project is relevant to NIH's mission to seek fundamental knowledge about living systems because it seeks to determine how epigenetic mechanisms influence the se- quence of events of early development and impact the formation of the embryo.

PI_NAMEs: BLYTHE, SHELBY ALEXANDER (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;Affinity Chromatography;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biochemical;Biological;biological systems;Cell Differentiation process;Cell Reprogramming;Cells;ChIP-seq;Chromatin;Chromatin Remodeling Factor;Competence;Complex;Development;Disease;domain mapping;Drosophila genus;Embryo;Embryonic Development;Enhancers;Ensure;Epigenetic Process;epigenetic regulation;Event;Gene Expression Regulation;gene regulatory network;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Goals;Grant;Human;Individual;innovation;Instruction;Knowledge;Learning;Logic;loss of function;Maps;Mass Spectrum Analysis;Measurement;Measures;Mission;Modeling;Modification;Molecular;mutant;Nature;novel;NuRD complex;operation;Organism;Output;Pattern;Play;prevent;Process;programs;recruit;regenerative biology;regenerative therapy;Regulatory Element;Research;Resources;Role;Shapes;Site;stem;stem cell biology;stem cell therapy;System;Testing;Therapeutic;Time;time use;transcription factor;United States National Institutes of Health

PROJECT_TITLE: Defining epigenetic mechanisms for embryonic patterning

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative The proposed research is highly relevant to public health because the identification of efficacious interventions that integrate mental health-exercise training to improve insulin resistance in adolescents with obesity and depression offers the prospect of mitigating type 2 diabetes (T2D) risk. Adolescent females from historically disadvantaged racial/ethnic and socioeconomic backgrounds disproportionately experience elevated depression symptoms, physical inactivity, poor cardiorespiratory fitness, obesity, insulin resistance, and youth-onset T2D. By rigorously studying the efficacy of cognitive-behavioral therapy (CBT), exercise training, and their combinations to increase physical activity/fitness and ameliorate insulin resistance in adolescent females at-risk for T2D with elevated depression symptoms, the proposed research is poised to contribute to the NIDDK's mission to combat T2D and improve people's health and quality of life.

PI_NAMEs: SHOMAKER, LAUREN BERGER (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accounting;Address;Adherence;Adolescence;Adolescent;Adult;Aftercare;arm;attentional control;Behavior Therapy;Body mass index;cardiorespiratory fitness;center for epidemiological studies depression scale;child depression;Chronic Disease;Cognitive Therapy;combat;Communities;comorbidity;comparative efficacy;Control Groups;cost;cost effective;cost effective intervention;Data;Depressed mood;depressive symptoms;Diabetes prevention;diabetes risk;Disadvantaged;Disease;Disproportionately impacts women;effective therapy;Effectiveness;efficacious intervention;efficacy study;Ethnic Origin;Ethnic Population;Exercise;exercise training;experience;Fasting;Female;Female Adolescents;fitness;follow-up;Frequencies;Goals;Health;Health education;Healthcare;High Risk Woman;Hour;improved;Individual;Insulin;Insulin Resistance;insulin sensitivity;Intervention;Interview;Life Expectancy;Mediating;Mediator;Mental Depression;Mental Health;Metabolic;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Pathway interactions;Persons;Phenotype;Physical activity;Physical Fitness;physical inactivity;Physiological;post intervention;Prevention;Prevention strategy;process evaluation;programs;Public Health;Quality of life;Race;racial population;Randomized;Randomized, Controlled Trials;Research;Risk;sedentary;socioeconomics;standard of care;Stress;Teenagers;Time;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DE

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE This project will discover new DNA methylation targets that can be used as biomarkers to predict the risk of low-grade oral premalignant lesions (OPLs) in becoming oral cancers. It is relevant to public health because the obtained information will allow the implementation of evidence-based personalized strategies for OPL treatment and oral cancer prevention, as well as advancing our knowledge on the epigenetic mechanisms driving the malignant progression of OPLs.

PI_NAMEs: TSAI, ROBERT Y (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Address;Appearance;Automobile Driving;Biological Markers;Biopsy;bisulfite sequencing;cancer prevention;cancer risk;carcinogenicity;Data;Dental;Disease;Disease Progression;DNA Methylation;Epigenetic Process;Event;evidence base;gene environment interaction;gene function;Gene Targeting;Genomic Segment;Genomics;Goals;Head and Neck Squamous Cell Carcinoma;Health;High grade dysplasia;high risk;Human;improved;Incidence;Intervention;Knowledge;learning algorithm;Left;Lesion;Logistic Regressions;Longitudinal Studies;Longterm Follow-up;machine learning algorithm;Malignant - descriptor;malignant mouth neoplasm;Malignant Neoplasms;Medical;Methods;Methylation;methylome;Minority;Modeling;Modification;Morphology;mouth squamous cell carcinoma;Mucous Membrane;Mutation;novel;Nucleotides;Oral;oral cancer prevention;oral carcinogenesis;oral cavity epithelium;oral dysplasia;Outcome;Output;Patients;personalized strategies;predictive marker;predictive modeling;premalignant;preservation;Prevention strategy;programs;Proteins;Public Health;random forest;Reporting;Research;Resolution;Risk;Risk Assessment;risk prediction;risk prediction model;Sampling;screening;sequencing platform;side effect;Site;Testing;Tobacco;Training;Treatment Side Effects;Validation;Visit;whole genome;Width

PROJECT_TITLE: Discovery of New DNA Methylation Biomarkers for Predicting the Malignant Outcome of Low-Grade Oral Dysplasia

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Palliative Care;Patient Safety

PHR: PROJECT NARRATIVE Renewal of this K24 Mid-Career Award in Patient-Oriented Research would enable the Principal Investigator, Dr. Supriya Mohile, to expand her research skills and mentoring activities to further the growth of a patient- oriented research program in geriatric oncology. Her multi-site cluster randomized studies have demonstrated that a geriatric assessment and management (GAM) intervention improves patient-centered and clinical outcomes of older patients with advanced cancer and their caregivers. The overarching research goals of this proposal are to: 1) develop and evaluate implementation strategies for GAM in oncology practices and 2) examine treatment tolerability in older patients with advanced cancer and aging-related conditions starting a new high-risk cancer treatment regimen.

PI_NAMEs: MOHILE, SUPRIYA G. (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Advanced Malignant Neoplasm;adverse outcome;Advocate;Affect;Aging;aging related;American Society of Clinical Oncology;Award;cancer clinical trial;cancer therapy;career;career development;Caregivers;Caring;chemotherapy;Clinic;Clinical;clinical care;Clinical Oncology;clinical practice;Clinical Trials;Cluster randomized trial;Communication;Communication Research;Community Clinical Oncology Program;comorbidity;Contracts;Data;Data Analyses;Data Set;Decision Making;Dose;editorial;Effectiveness;Elderly;Endowment;Exclusion;falls;Fostering;functional improvement;Funding;Geriatric Assessment;Goals;Grant;Growth;Guidelines;Health;health assessment;Health Status;High-Risk Cancer;Hospitalization;implementation evaluation;implementation science;implementation strategy;improved;improved outcome;interest;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Lead;Leadership;Learning;Low Prevalence;Malignant Neoplasms;Manuscripts;Medicine;Mentors;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Modification;older adult;older patient;Oncologist;Oncology;oncology program;Outcome;Outcomes Research;patient oriented;patient oriented research;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Polypharmacy;Principal Investigator;Procedures;Prognosis;programs;provider factors;Publishing;Randomized;randomized, clinical trials;Recommendation;Relative Risks;Reporting;Research;Research Personnel;Resources;Risk;satisfaction;Scientist;secondary analysis;Site;skills;standard of care;success;Symptom Burden;Testing;Time;Toxic effect;Training Support;Treatment Protocols;treatment risk;Treatment-related toxicity;United States National Institutes of Health;Universities;uptake;Woman

PROJECT_TITLE: A Patient-Oriented Research Program in Geriatric Oncology

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Although molecular targeted therapy has dramatically changed how we treat cancer, the treatment for non Hodgkin’s lymphomas remains an unmet need for new therapeutic strategies. Our studies have uncovered that the MUSASHI2 (MSI2) contributes to B-cell lymphoma cell growth and drives resistance to a protein Arginine methyltransferase (PRMT) inhibitor. This proposal studies the PRMT-MSI2 axis in both mouse models and in human B-cell lymphoma to develop a new therapeutic strategy for this disease.

PI_NAMEs: KHARAS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adult;Advanced Malignant Neoplasm;Antibodies;Arginine;Automobile Driving;B-Cell Lymphomas;B-Lymphocytes;BCL-2 Protein;BCL2 gene;Binding;Binding Proteins;Biology;cell growth;Cell Line;Cell Physiology;Cells;Clinic;Clinical;Communication;CRISPR screen;Data;Dependence;Disease;Enzymes;Epigenetic Process;Failure;Family;Genes;Genetic;genome-wide;Growth;Hematologic Neoplasms;Histones;Human;Impairment;improved;in vivo;inhibitor;inhibitor therapy;Laboratories;large cell Diffuse non-Hodgkin's lymphoma;leukemia;loss of function;Lymphoma;Lymphoma cell;Lymphomagenesis;Lysine;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Methylation;Modality;Modification;molecular targeted therapies;mouse model;Mus;mutant;Mutation;MYC Family Protein;Nature;new therapeutic target;non-histone protein;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;Oncogenic;Oncoproteins;Outcome;overexpression;Pathogenesis;Patients;Play;Post-Translational Protein Processing;programs;Proliferating;protein expression;Protein Family;Protein-Arginine N-Methyltransferase;Proteins;Publishing;Recurrence;relapse patients;Resistance;resistance mechanism;response;RNA Recognition Motif;RNA-Binding Proteins;Role;Sampling;Site;small hairpin RNA;Solid Neoplasm;stem;stem cells;System;targeted treatment;technological innovation;Therapeutic;transcriptome;Translations;translatome;tumor;tumor eradication;Up-Regulation

PROJECT_TITLE: Understanding resistance mechanisms to protein arginine methyltransransferase Inhibitors in Lymphoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Suicide;Suicide Prevention;Women's Health Research

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: Given that suicide is the second leading cause of death of children and adolescents, this study addresses the National Institute of Mental Health's call for greater understanding of the brain/behavior mechanisms underlying youth suicide. Specifically, we will use functional magnetic resonance imaging (fMRI) and real- world ecological momentary assessment (EMA) to advance what is known about the brain/behavior mechanisms underlying self-critical rumination (defined as persistent negative self-evaluation) and self- reassurance (providing compassion to self) in the context of youth suicide risk. Ultimately, greater understanding of these two constructs will facilitate the development of novel interventions targeting these symptom/circuit mechanisms related to youth suicide.

PI_NAMEs: KUDINOVA, ANASTACIA Y. (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 15 year old;Address;Adolescence;Adolescent;Adult;Age;age group;Anterior;Area;Behavior;Behavior assessment;Behavior Disorders;Behavioral Mechanisms;biobehavior;Biological;Brain;career development;Cause of Death;Child;cingulate cortex;Collaborations;Communities;Compassion;Complex;critical developmental period;critical period;Data;Development;Diagnostic;Dimensions;Dorsal;Ecological momentary assessment;Environment;environmental change;experience;Feeling suicidal;Female;Female Adolescents;Frequencies;Functional Magnetic Resonance Imaging;Future;girls;Goals;Human;Image;imaging approach;Impairment;in vivo;Individual;Inflammatory Response;innovation;Insula of Reil;interest;Intervention;Investigation;K-Series Research Career Programs;Laboratories;Length;Life;Link;male;Mental disorders;Mentors;Mentorship;Methodology;Mood Disorders;National Institute of Mental Health;neural;neural circuit;Neurobiology;neuroimaging;neuromechanism;novel;peer;Play;Prefrontal Cortex;Prevalence;Prevention Research;preventive intervention;Price;Process;programs;promote resilience;prospective;Psychiatry;Psychopathology;Psychophysiology;psychosocial;Psychotherapy;Published Comment;recruit;Research;Research Personnel;Rest;Role;rumination;Sampling;Self Assessment;self-compassion;Self-Examination;Series;Severities;Sex Differences;skills;Stress;suicidal behavior;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptoms;Techniques;Technology Assessment;Teenagers;Testing;Thinking;Time;Training;Universities;women versus men;Work;young adult;Youth

PROJECT_TITLE: Neural Mechanisms Underlying Self-Critical Rumination and Self-Reassurance and Suicidal Thoughts and Behavior in Youth

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Human Genome;Nanotechnology;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Usher Syndrome

ORG_CITY: SEATTLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Usher Syndrome type II (USH2) is inherited in an autosomal recessive manner; however, in approximately 20% of patients with clinical features typical for USH2, only one mutation of USH2A has been identified by whole exome sequencing, thereby precluding a definitive diagnosis. Genomic assembly of the USH2A loci that combines the base-level accuracy of Illumina short-read sequencing with the longer read lengths obtained from Nanopore based amplification-free targeted sequencing will provide a more accurate detection of pathogenic variants in monoallelic USH2A patients. Candidate variants will be further interrogated using CRISPR-Cas9 editing technology in patient-derived retinal organoids to validate the pathogenicity of these novel non-coding variants and establish their sufficiency and necessity in causing disease in USH2A monoallelic subjects.

PI_NAMEs: MUSTAFI, DEBARSHI  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Accounting;Adult;Alleles;autosome;base;Biological Assay;Biological Models;Blindness;Brain;Catalogs;Cell Culture System;Cell Culture Techniques;Cells;Childhood;Cilia;ciliopathy;Classification;Clinical;clinically relevant;Code;cohort;Complex;congenital hearing loss;CRISPR/Cas technology;Data Set;deafness;Detection;Diagnosis;differentiation in vitro;Disease;disease phenotype;Electrophysiology (science);Engineering;epigenomics;exome sequencing;Exons;Family member;gene editing technology;gene product;Gene Targeting;Genes;Genetic Variation;genome sequencing;Genomics;Genotype;Haplotypes;Health;Human;human disease;Inherited;Integral Membrane Protein;Kidney;Knock-in;Length;Light;Liver;Luciferases;Mammalian Cell;Maps;Mendelian disorder;Microscopy;Modeling;Mutation;nanopore;novel;Nucleic Acid Regulatory Sequences;Organ;Organoids;Pathogenicity;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;Pattern;Phase;Phenotype;Photoreceptors;pluripotent stem cell differentiation;Population;Proteins;rare variant;reconstruction;Reporter;Retina;Retinal Degeneration;Retinal Diseases;Role;Sensorineural Hearing Loss;sensory neuropathy;targeted sequencing;Technology;Therapeutic;Tissues;Transport Process;Untranslated RNA;USH2A gene;Usher Syndrome;Usher Syndrome Type 2;Variant;variant detection;Vision;Visual impairment

PROJECT_TITLE: The role of non-coding variants in Usher disease


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Hyperprolactinemia due to prolactin-secreting pituitary tumors frequently affects both the central and peripheral reproductive system, leading to hypogonadism and subfertility. Translational research has been limited by lack of pituitary tumor models. We have developed a unique 3-dimensional (3D) pituitary tumoroid culture system that can maintain differentiated prolactin-secreting pituitary tumor cells as a preclinical model for drug discovery.

PI_NAMEs: HEANEY, ANTHONY P (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agonist;angiogenesis;biobank;Biological Assay;Biomedical Engineering;Catabolism;Cell Adhesion;Cell model;Cells;Collagen;CRISPR library;Custom;Data;Development;Digit structure;Disease remission;Dopamine Agonists;Dose;drug discovery;Drug Targeting;drug use screening;Event;Excision;Exclusion;Exhibits;experience;Extracellular Matrix;follow-up;high throughput screening;high-throughput drug screening;Hormone secretion;Human;human disease;Hyperprolactinemia;Hypogonadism;Immune response;In Vitro;individual patient;inhibitor;innovation;interest;Lead;Libraries;Literature;matrigel;Medical;Methodology;Modeling;Molecular;Morphology;multidisciplinary;Mus;neoplastic cell;Neuroendocrine Tumors;novel;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Pituitary Gland;Pituitary Neoplasms;Poison;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Prolactin;Prolactin Secreting Pituitary Gland Neoplasm;Prolactinoma;Proliferating;Rattus;Refractory;Reproductive system;research and development;Research Personnel;response;RNA library;Rotation;segregation;side effect;Signal Transduction;Silicon Dioxide;small hairpin RNA;small molecule inhibitor;Specificity;STAT3 gene;statistics;subfertility;success;System;Testing;therapy development;Time;Toxic effect;Transcript;transcriptome;transcriptome sequencing;transcriptomic profiling;Translational Research;tumor;Tumor Subtype;Validation;Work

PROJECT_TITLE: Development of a patient-derived tumoroid culture system to explore novel medical treatments for refractory prolactinomas


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: ORTHOPEDICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Osteosarcoma (OS) is an aggressive primary bone cancer that mainly affects children and young adults, yet the survival rate has not changed in over three decades. The lack of effective therapies for OS is largely due to our limited understanding of OS biology, heterogeneity and drug resistance. This project will pioneer the application of tissue engineered 3D in vitro models to fill in the above gaps of knowledge and accelerate discovery of novel therapeutics to improve the treatment outcomes of this devastating disease.

PI_NAMEs: SWEET-CORDERO, ERIC ALEJANDRO;YANG, FAN  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Adherent Culture;Adopted;Adoption;Affect;angiogenesis;anti-cancer research;ATAC-seq;Automobile Driving;Bar Codes;Biocompatible Materials;Biology;bone;Bone Tissue;cancer cell;Cancer Model;Cell Line;Cell model;Cell Proliferation;Cells;Cellular Morphology;chemotherapy;Child;Combination Drug Therapy;Combined Modality Therapy;Communities;cost;Cues;Data;design;Development;Disease;disease heterogeneity;DNA;drug candidate;drug discovery;Drug resistance;drug response prediction;effective therapy;Engineering;established cell line;Evaluation;Exhibits;Experimental Models;Extracellular Matrix;Gelatin;Gene Amplification;Genomics;Goals;Heterogeneity;high dimensionality;high throughput screening;high-throughput drug screening;Hydroxyapatites;improved;in vitro Model;in vivo;invention;Knowledge;Lead;Legal patent;Malignant Bone Neoplasm;Mediating;Mind;mineralization;Minerals;Modeling;mouse model;Mus;Nanoporous;new therapeutic target;novel;novel therapeutics;Oncogenes;Osteogenesis;Osteosarcoma;Outcome;Pathology;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phenotype;Physiological;porous hydrogel;Positioning Attribute;pre-clinical;primary bone cancer;Receptor Protein-Tyrosine Kinases;Regulatory Pathway;Reporting;Research;Resistance;resistance mechanism;Resources;response;Role;scaffold;Scientist;screening;Signal Transduction;single-cell RNA sequencing;soft tissue;spheroids;stemness;Survival Rate;targeted treatment;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Tissue Engineering;tool;transcriptome sequencing;Treatment outcome;tumor;Work;Xenograft Model;young adult

PROJECT_TITLE: Engineering 3D Osteosarcoma Models to Elucidate Biology and Inform Drug Discovery


NIH_SPENDING_CATS: Batten Disease;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE The neuronal ceroid lipofuscinoses (NCLs) are among a number of lysosomal storage diseases that are characterized by progressive loss of vision culminating in blindness due to degeneration of both the retina and the central nervous system (CNS) visual pathways. Lysosomal storage diseases resulting from lack of specific soluble lysosomal enzymes, including the CLN2 form of NCL, can be treated by delivery of the missing enzyme to the affected tissues. Using a canine model for CLN2 disease, the proposed research will test the hypothesis that combined AAV- mediated gene therapy of the retina and CNS will prevent degeneration of both the retina and central visual pathways in this disease.

PI_NAMEs: KATZ, MARTIN L (contact)

PROJECT_TERMS: adduct;Affect;Age Months;base;Binding Proteins;Blindness;Blood;Brain;canine model;Canis familiaris;Cell Fraction;Cell membrane;Cell surface;Cells;cellular transduction;Central Nervous System;Cerebrospinal Fluid;Child;Clinic;Clinical;CLN2 gene;CNS degeneration;County;Development;Disease;disease model;Distant;DNA;Dog Diseases;early childhood;efficacy testing;end stage disease;Endocytosis;Endoplasmic Reticulum;Endosomes;enzyme replacement therapy;Enzymes;Extracellular Space;Eye;follow-up;gene therapy;Gene Transduction Agent;gene-targeted therapy;Genes;Goals;Golgi Apparatus;Human;IGF Type 2 Receptor;in vivo;Infusion procedures;Injections;intravitreal injection;Life;life span;lysosomal proteins;Lysosomal Storage Diseases;Lysosomes;mannose 6 phosphate;Mediating;Meditation;Methods;Modeling;Mutation;Nervous System Physiology;Neurologic;Neurologic Signs;Neuronal Ceroid-Lipofuscinosis;null mutation;Organ;Pathology;Pathway interactions;Patients;Periodicals;preclinical study;preservation;prevent;Protein Secretion;Proteins;receptor;Recombinant Proteins;Recombinants;Research;Retina;Retinal Degeneration;Retinal gene therapy;Safety;Site;Structure;System;targeted delivery;Testing;Time;Tissues;tripeptidyl aminopeptidase;uptake;Variant;Vision;Visual;Visual Pathways;Visual System;Vitreous humor

PROJECT_TITLE: Gene therapy for preserving the visual system in lysosomal storage diseases


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Microbiome;Natural Products

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative. A large fraction of our current medical arsenal operates through G protein-coupled receptors (GPCRs). This interdisciplinary team proposal investigates three underlying molecular mechanisms of GPCR engagement at the host-microbiota interface – gut microbiota-derived GPCR ligands (Aim 1a), candidate endogenous GPCR ligands from human tissues (Aim 1b), and bacterial metabolism of and responses to GPCR drugs (Aim 2). The proposed studies will represent a heretofore unprecedented structure-function-based exploration of the “dark matter” of the metabolome at the host-bacteria interface and how it is “sensed” by the host, which could broadly illuminate new GPCR- and microbiome-targeted therapeutic strategies.

PI_NAMEs: CRAWFORD, JASON MICHAEL (contact);JOHNSON, CAROLINE HELEN;PALM, NOAH WOLCOTT

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Animals;Area;Bacteria;bacterial metabolism;Bacterial Transformation;Biological;Biological Process;Biology;candidate identification;Cells;Chemicals;Collection;Communication;dark matter;Data;Data Set;Disease;drug discovery;drug metabolism;Drug Receptors;Drug Targeting;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;guided inquiry;gut bacteria;gut microbes;gut microbiota;Health;high throughput screening;host microbiota;Human;human disease;Human Microbiome;human model;human tissue;Immune response;Intestines;Lead;Ligands;Measurement;Mediating;Medical;member;Metabolic Biotransformation;Metabolic Pathway;Metabolism;metabolome;metabolomics;Microbe;microbial;microbiome;microbiota;Modernization;Molecular;Natural product discovery;Natural Products;novel;Organism;Orphan;Pathway interactions;Pharmaceutical Preparations;Phylogenetic Analysis;Physiology;Production;programs;receptor-mediated signaling;Reporting;Research;response;Sampling;screening;secondary metabolite;Serum;Signal Transduction;Signaling Molecule;small molecule;Source;stressor;Structure;Structure-Activity Relationship;System;targeted treatment;Technology;Therapeutic

PROJECT_TITLE: Microbial Chemical Sensing and Host Responses


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

ORG_STATE: FL

PHR: Project Narrative We will employ cutting-edge imaging techniques to investigate the dynamic interplay that takes place in the adult brain between cortical elements over the course of learning. The results from the proposed experiments will provide a higher level of understanding regarding the circuit and synaptic mechanisms that underlie perceptual learning. Our findings will provide a comprehensive framework under which to probe the progression of learning- related changes in the cortex and may lead to a deeper understanding of learning disabilities as well as uncovering novel avenues that promote plasticity in the mature brain after injury, stroke or prolonged sensory loss.

PI_NAMEs: RODRIGUEZ, GABRIELA DEL MAR (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Acetylcholine;Address;Adult;Architecture;area striata;area V1;Attention;Award;Behavioral;Brain;Calcium;cholinergic;Chronic;collaborative environment;Data;Dendritic Spines;Development;Discrimination;Discrimination Learning;discrimination task;Elements;Endowment;Enhancers;excitatory neuron;Exhibits;experience;experimental study;flexibility;Florida;Foundations;Functional Imaging;Future;Genetic;Head;Image;Imaging Techniques;in vivo calcium imaging;Individual;individual response;inhibitory neuron;Injury;innovation;Learning;Learning Disabilities;learning progression;Mammals;Maps;Modeling;Molecular;Monitor;Nature;neural;neural circuit;Neurons;Neurosciences;novel;novel strategies;Optics;orientation selectivity;Perception;Perceptual learning;Performance;Phase;Population;Positioning Attribute;Primates;Process;programs;Property;Psychological reinforcement;Recovery;recruit;Research;response;Rewards;sensor;Sensory;sensory cortex;Shapes;Signal Transduction;skills;spatiotemporal;Specificity;Stimulus;Stroke;Structure;Synapses;Synaptic plasticity;Task Performances;Technical Expertise;Techniques;Technology;Training;training opportunity;Tupaia;Tupaiidae;two-photon;V1 neuron;Visual;Visual Cortex;visual discrimination;visual stimulus

PROJECT_TITLE: Circuit dynamics underlying perceptual learning in the functionally organized visual cortex


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: This research will advance our understanding of how cholesterol is handled in the retina and may facilitate the development of pharmacologic treatments for such eye diseases as age-related macular degeneration.

PI_NAMEs: PIKULEVA, IRINA A (contact)

PROJECT_TERMS: Ablation;Affect;Age related macular degeneration;Aging;Anabolism;Animal Model;apolipoprotein D;Apolipoprotein E;Apolipoproteins;Blindness;Bruch's basal membrane structure;Cell membrane;Cellular Membrane;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;cholesterol trafficking;Circulation;Clinical Trials;combat;Cytochrome P450;Data;density;Deposition;Development;Disease;Dose;Drug Delivery Systems;Drug Prescriptions;Drug vehicle;Drusen;Elderly;Endocytosis;Enzymes;Esterification;Evaluation;Eye diseases;FDA approved;Genes;Genetic;Genetic study;Grant;Hamsters;High Density Lipoproteins;Human;hydroxypropyl-beta-cyclodextrin;In Situ;Industrialization;insight;Knowledge;Link;Lipids;Lipoproteins;Location;Low-Density Lipoproteins;Maintenance;Measures;Mediating;Membrane;Mesocricetus auratus;Metabolism;Modeling;mouse model;Mus;novel therapeutics;older adult;Output;particle;Pathogenesis;Pathway interactions;patient population;Phagocytosis;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Photoreceptors;Plasma;Process;progression risk;prospective;Proteins;Research;Retina;Risk Factors;Rodent;Role;Side;Simvastatin;Source;Structure of retinal pigment epithelium;Study models;subcutaneous;sulfated glycoprotein 2;Testing;Transgenic Mice;uptake

PROJECT_TITLE: Cholesterol Homeostasis in the Retina


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This research addresses the genetic underpinnings of adaptive trait evolution and reproductive isolation, and the determinants of genomic diversity. Understanding of the genetic architecture of human disease will benefit from this work’s emphases on detecting local adaptation (which is relevant to immune performance and the risk of diabetes and heart disease) and on interactions among genetic variants (which may contribute to the variable penetrance of many diseases). This research will benefit the study of insect disease vector evolution, and its focus on genetic incompatibilities may inform the causes of miscarriage and couple infertility and the disease risk of Neanderthal genetic variants.

PI_NAMEs: POOL, JOHN E (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;African;Architecture;computer studies;cost effective;diabetes risk;Disease;disorder risk;Drosophila genus;European;Evolution;experimental study;Future;Generations;Genes;Genetic;genetic architecture;Genetic Drift;Genetic Epistasis;genetic resource;Genetic study;genetic variant;Genetic Variation;Genome;genome annotation;genomic data;Genomics;Heart Diseases;human disease;Immune;Individual;Infertility;insect disease vector;Maps;Medical;Natural Selections;novel strategies;Penetrance;Performance;Population;Portraits;Process;programs;Reproduction;reproductive;Research;Role;scale up;Shapes;Signal Transduction;Spontaneous abortion;System;tool;trait;Transgenic Organisms;Variant;Work

PROJECT_TITLE: Genomic Diversity and the Architectures of Adaptation and Incompatibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Nanotechnology;Radiation Oncology;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The goal of this proposal is to combine photodynamic therapy and magnetophoresis to improve the treatment of triple negative breast cancer. A photosensitizer-loaded magnetic nanoparticle will be used that exhibits minimal self-quenching of reactive oxygen species generation. Moreover, a novel magnetic device will be used to enhance the penetration of photosensitizer-loaded magnetic nanoparticles into tumors.

PI_NAMEs: TSOURKAS, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Abscopal effect;Adjuvant Therapy;amphiphilicity;Binding;Biomedical Engineering;Blood Vessels;Breast Cancer Treatment;Breast-Conserving Surgery;Cancer Cluster;Cell Line;chemical property;chlorin;Circulation;Contralateral;Custom;cytotoxicity;density;design;Diameter;Diffuse;Disease;Drug Kinetics;effective therapy;efficacy evaluation;Encapsulated;Excision;Exhibits;Extravasation;Faculty;Formulation;Generations;Goals;Hematology;Histopathology;imaging properties;Immune response;Immunohistochemistry;improved;innovative technologies;intravenous administration;iron oxide nanoparticle;irradiation;Lasers;lipophilicity;Location;magnetic devices;magnetic field;Magnetic nanoparticles;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mastectomy;member;mesothelin;Modeling;Monitor;mouse model;nanocluster;nanoformulation;nanoparticle;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;novel;Operative Surgical Procedures;Optics;Patients;Penetration;Pennsylvania;Photosensitizing Agents;Phototoxicity;Primary Neoplasm;Production;PUVA Photochemotherapy;Radial;Radiation;Radiation Oncology;Radiation therapy;Radiology Specialty;Reactive Oxygen Species;Recombinant Antibody;Singlet Oxygen;Site;Solid Neoplasm;Solubility;Specificity;standard of care;superparamagnetism;Surface;Testing;Time;Tissues;Toxic effect;Toxicology;Treatment Efficacy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;Universities;uptake;Water;Work

PROJECT_TITLE: Combined magnetophoresis and photodynamic therapy for the treatment of TNBC

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Complementary and Integrative Health;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: CARNEGIE INSTITUTION OF WASHINGTON, D.C.

ORG_STATE: DC

PHR: Project Narrative Lactobacilli bacteria are probiotic benefactors of human health that associate with mucosal tissues where they prevent infections, lower cancer risk, and improve metabolism, but the evolutionary pressures selecting for genes that confer their association with host mucosae are understudied. The goal of this proposal is to improve our understanding of how Lactobacillus plantarum surface proteins that recognize host-specific ligands favor competition between bacterial strains at the host mucosal surface. The work will reveal fundamental mechanisms that can be applied to engineer better probiotics for human health.

PI_NAMEs: LUDINGTON, WILLIAM BASIL (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: activation-induced cytidine deaminase;Adhesions;Animals;Bacteria;Bacterial Adhesins;Binding;Bioinformatics;Biological Assay;Biological Models;cancer risk;Cell Adhesion Molecules;Cell surface;Cell Wall;Cells;Colon Carcinoma;combat;commensal microbes;Communities;Competitive Binding;cost;Data;Digestion;Digestive System Disorders;Drosophila genus;Drosophila melanogaster;Engineering;Enzymes;Evolution;Fermentation;fitness;fly;Food;Future;Gastrointestinal tract structure;gene discovery;Gene Proteins;Genes;Genetic;genetic resource;Genus staphylococcus;glycosylation;Goals;Grant;Growth;gut colonization;gut microbiome;gut microbiota;Health;Homologous Gene;host microbiome;Human;Image;immunoregulation;improved;In Vitro;in vivo;Incidence;Infection prevention;Island;Knock-out;Knowledge;Lactobacillaceae;Lactobacillus;Lactobacillus plantarum;Lead;Ligand Binding;Ligands;Malignant neoplasm of gastrointestinal tract;Measures;Membrane Proteins;Metabolic syndrome;Metabolism;Microbe;microbial;Microbial Biofilms;microbiome;microbiome composition;Modeling;Molecular;Mucous body substance;Mucous Membrane;mutant;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Obesity;pathogen;physical property;Polysaccharides;Population;Postdoctoral Fellow;pressure;Probiotics;Property;Proteins;receptor;recruit;Resolution;Resources;Risk;Role;Serine;Site;spatiotemporal;Specificity;Streptococcus;Structure;success;sugar;Surface;Testing;Therapeutic;Time;Tissues;Training;unpublished works;Visualization;Work

PROJECT_TITLE: Serine-rich repeat proteins in evolution of Lactobacillus-host specificity

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Spatial misperception is a common cause of injuries in elderly that are highly morbid and costly. Here we apply a rigorous framework to (i) parse out sensory contributions to spatial orientation in aging, (ii) and (ii) examine whether they correspond with age-related vestibular physiologic changes and fall risk. These are crucial steps to identify distinct age-related changes in spatial orientation and devise bi- omarkers to track aging effect on balance function.

PI_NAMEs: KHERADMAND, AMIR  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Affect;age effect;age related;age related biomarkers;age related changes;Aging;Bayesian Modeling;Biological Markers;body position;Brain;Cerebrum;Clinical;comorbidity;Compensation;cost;Cues;Dependence;Development;diagnostic tool;disabling symptom;Disorientation;Dizziness;effective therapy;Elderly;Equilibrium;experience;Eye;fall risk;falls;Feeling;Force of Gravity;haptics;Head;high risk;Human;human old age (65+);Individual;Injury;Link;mathematical model;Measurement;Measures;Methods;Modality;Motion;multisensory;Musculoskeletal Equilibrium;Natural Source;neural;neurophysiology;Noise;novel;novel strategies;older adult;Older Population;otoconia;Patients;Perception;personalized medicine;Physiological;Physiology;Population;Positioning Attribute;Posture;posture instability;potential biomarker;Process;Process Measure;Psychophysics;Recording of previous events;rehabilitation strategy;Rehabilitation therapy;Research;research clinical testing;response;Risk Factors;Sensory;sensory input;sensory integration;sensory mechanism;Sensory Process;Signal Transduction;Space Perception;spatial integration;Testing;treatment program;treatment strategy;Uncertainty;Vestibular Diseases;Vestibular function;Vestibular loss;vestibular system;Visual;visual tracking;Visuospatial;Work

PROJECT_TITLE: Aging and sensory contributions to spatial orientation

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Human Genome;Prevention;Rare Diseases;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE We will adapt and assess the feasibility of an interactive, online version of an intervention, Let's Talk, to improve cascade screening for Lynch syndrome. The expected outcomes of this project will move the field forward in tackling challenges associated with cascade screening. These data can inform future work to increase cascade screening uptake and identification of individuals with Lynch syndrome across diverse care settings and with other genetic conditions.

PI_NAMEs: ROBERTS, MEGAN C. (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Affect;Blood Tests;cancer prevention;cancer risk;Caring;cascade genetic testing;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical;Colorectal Cancer;Complex;Consultations;coping;COVID-19;COVID-19 pandemic;Data;design;Development;Diagnosis;disorder control;disorder prevention;education resources;Educational Materials;effective therapy;Effectiveness;effectiveness outcome;effectiveness testing;Electronic Mail;Ethnic Origin;evidence based guidelines;Familial Hypercholesterolemia;Family;Family dynamics;Family member;Feedback;First Degree Relative;follow-up;Frequencies;Future;Genetic Counseling;genetic counselor;Genetic Diseases;Genetic Services;genetic testing;Genomics;Goals;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;Home;human centered design;implementation measures;implementation outcomes;improved;Incidence;Individual;Inherited;Intervention;intervention mapping;Knowledge;Language;Letters;Life;lifetime risk;Medical center;Methodology;Methods;Needs Assessment;novel;online intervention;online version;Other Genetics;Outcome;Outcome Study;Paper;Patient Preferences;Patients;Persons;pilot test;preference;Process;Provider;Public Health;Race;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reporting;Research;Resources;response;Risk;Sampling;screening;screening guidelines;Self Efficacy;service delivery;skills;Spanish;Spanish/English;Surveys;Telephone;Testing;Text;theories;tool;uptake;usability;Visit;web site;Work

PROJECT_TITLE: Let's Talk: Overcoming barriers to the uptake of cascade screening through a stakeholder-informed online intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (O1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE  Invasive pulmonary aspergillosis, a common fungal infection among immunocompromised patients, has poor outcomes including a high mortality rate. The increasing number of susceptible patients and the threat of antifungal-resistant strains makes the development of host-centric interventions a high priority for public health. This project will use mathematical modeling and experimental data to determine new potential treatments in this infection.

PI_NAMEs: SORDO VIEIRA, LUIS ALFONSO (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acute Lung Injury;Advisory Committees;Air;Allergic Bronchopulmonary Aspergillosis;Alveolar;Animal Experimentation;antagonist;Aspergillosis;Aspergillus;Biology;C5AR2 gene;career;Characteristics;chemotherapy;Complement;Complement 5a;Complement Activation;Complement component C5;Complement Inactivators;complement pathway;complement system;Complex;Computer Models;Coupled;Data;Death Rate;design;Development;Disease;Doctor of Philosophy;effective therapy;Endothelium;Environment;Epithelium;experimental study;extracellular;FDA approved;Filament;Florida;Fungal Drug Resistance;Genetic;Germination;Grant;Growth;Heme;Hemorrhage;Host Defense;Human;Hyphae;Immunity;Immunocompromised Host;Immunologics;Immunology;Impairment;improved outcome;in silico;in vivo;in vivo evaluation;in vivo Model;Infection;inflammatory marker;Inhalation;inhibitor;Injury;Innate Immune System;Intervention;Link;Literature;Lung;lung injury;mathematical model;Mediating;Medicine;Mentors;Microbiology;Modeling;Molds;mortality;mouse model;multi-scale modeling;Mus;Mycoses;Natural Immunity;novel therapeutic intervention;Outcome;pathogen;Pathogenesis;patient population;Patients;Penetration;Phase;Physicians;Predisposition;Process;public health priorities;Pulmonary Inflammation;receptor;Reproduction spores;Research;Research Personnel;resistant strain;Role;Scientist;Series;Signal Transduction;Site;System;Testing;The science of Mycology;Therapeutic immunosuppression;Thinking;Time;tissue injury;tool;Training;Transplantation;treatment optimization;Universities;Writing

PROJECT_TITLE: Tuning complement-mediated immunity in aspergillosis: a systems medicine approach

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: HOUGHTON

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Alterations in sugar uptake and activity of facilitative sugar transporters – GLUTs - arise as a biomarker of metabolic diseases, such as obesity, diabetes, and cancer. Understanding the differences, the composition, and activity of GLUTs between cells provides the grounds for distinguishing cell types and subtypes and for more accurate detection of metabolically compromised cells. The current research established GLUT-specific fluorescently-labeled molecular probes for application in biochemical and biomedical research and cancer detection.

PI_NAMEs: TANASOVA, MARINA  (contact)

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Address;Advanced Development;analog;Animals;Biochemical;Biochemistry;Biological Assay;Biological Markers;Biology;Biomedical Engineering;Biomedical Research;Breast Cancer cell line;cancer cell;Cancer Detection;cancer diagnosis;cancer type;Cell Culture Techniques;Cell Line;cell type;Cells;cellular imaging;Cellular Metabolic Process;Characteristics;Chemicals;Chemistry;Collaborations;Color;Creativeness;Cyclotrons;Dependence;design;Detection;Development;Diabetes Mellitus;Diagnostic;Dietary Sugars;Discrimination;Disease;disease diagnosis;Disease Progression;Early Diagnosis;Education;educational atmosphere;Engineering;Environment;experience;Fingerprint;Flow Cytometry;Fluorescence;Fostering;Foundations;Fructose;Glucose;Glucose Transporter;GLUT-2 protein;Goals;Growth;hands on research;Health;Image;imaging agent;imaging probe;Imaging Techniques;improved;in vivo;in vivo imaging;innovation;interest;Knowledge;Label;Link;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Mammalian Cell;Measures;Metabolic;Metabolic Diseases;Metabolism;Methods;Michigan;Mission;Modeling;Molecular;molecular modeling;Molecular Probes;Molecular Target;Monitor;multidisciplinary;next generation;non-invasive imaging;Normal Cell;novel;Nutritional;Obesity;Onset of illness;Organic Chemistry;Organic Synthesis;Outcomes Research;Oxidative Stress;Patients;Positron-Emission Tomography;programs;pyranose;Radiolabeled;radiotracer;real time monitoring;Research;Research Personnel;Research Project Grants;response;Scientist;screening;SLC2A1 gene;SLC2A12 gene;Stimulus;Strategic Planning;Structure;Students;sugar;Supervision;targeted agent;Testing;Therapeutic;therapeutic target;treatment response;undergraduate student;United States National Institutes of Health;Universities;uptake;Validation;Visualization;Work;Yeasts

PROJECT_TITLE: Molecular probes for targeting facilitative fructose transporters (GLUTs) in biochemical and biomedical applications

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE: Cholestatic liver diseases, including biliary atresia, are the leading indication for pediatric liver transplantation. Evidence suggests that the unfolded protein response (UPR) is important in the progression of several adult liver diseases, yet the UPR is understudied in pediatric cholestatic liver diseases. We aim to define the role of the liver XBP1 pathway of the UPR postnatally and in models of cholestatic liver diseases in mice and human patients with biliary atresia in order to develop UPR specific therapeutic interventions for pediatric patients with cholestatic liver diseases.

PI_NAMEs: KRIEGERMEIER, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adult;Affect;age related changes;Agonist;Apoptosis;Award;bile acid metabolism;Bile Acids;Biliary Atresia;Binding Proteins;career;career development;Cells;Cellular Stress;Chemicals;Childhood;Childhood Injury;ChIP-seq;Cholestasis;Cholic Acids;Chronic;comparison control;Complex;Data;Data Analyses;Degradation Pathway;design;Development;Development Plans;Disease;disease model;Disease Progression;disorder control;DNA Binding;DNA-Binding Proteins;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Experimental Designs;Extramural Activities;feeding;Funding;Future;Gene Expression Regulation;Gene Transfer;Genes;Genetic;Goals;Hepatic;Hepatocyte;Hepatology;Human;human disease;Hydrophobicity;Impairment;Injections;Injury;Inositol;Intervention;Investigation;Knock-out;Knockout Mice;Knowledge;Laboratories;laboratory experience;lectures;Liver;Liver diseases;liver injury;liver transplantation;Mediating;Medical;Mentors;misfolded protein;Modeling;Molecular;mouse model;Mus;neonatal mice;neonate;new therapeutic target;novel;Outcome;Pathway Analysis;Pathway interactions;Patients;Pattern;pediatric patients;pharmacologic;Phenotype;Physicians;postnatal;postnatal development;protein degradation;Proteins;proteostasis;Publishing;Reaction;Regulation;Research;Research Training;response;restoration;Role;Scientist;Severities;Signal Pathway;Signal Transduction;skills;Techniques;Therapeutic;Therapeutic Intervention;Time;Tissues;Training;transcription factor;transcriptome sequencing;transcriptomics;Translational Research;Transplantation;treatment response;Tunicamycin;Universities;Western Blotting

PROJECT_TITLE: The Unfolded Protein Response in Murine and Pediatric Cholestatic Liver Diseases

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Women's Health Research

PHR: PROJECT NARRATIVE Women living in low- and middle-income countries (LMICs) suffer extremely high mortality if they are diagnosed with breast cancer, in part because women in these regions are more likely to be diagnosed with late-stage cancer. Programs using clinical breast examination (CBE) to screen for breast cancer have been shown to decrease late-stage diagnoses and improve cancer mortality but are difficult to implement in the resource-constrained healthcare systems of LMICs. This research aims to work with primary care providers and patients to develop strategies for implementing CBE screening programs in South Africa, which is a necessary first step to reducing mortality for South African women diagnosed with breast cancer.

PI_NAMEs: O'NEIL, DANIEL S (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adherence;Adoption;Africa;Africa South of the Sahara;barrier to care;behavior change;behavior change wheel;Behavioral;black women;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;breast cancer survival;breast exam;cancer care;Cancer Control;cancer health disparity;career;career development;Caring;Case Fatality Rates;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;collaborative approach;Country;Data;Data Analyses;design;detection method;Diagnosis;Early Diagnosis;Early identification;Educational Curriculum;Effectiveness;effectiveness measure;Eligibility Determination;Environment;Evaluation;Excess Mortality;experience;Exposure to;Face;Foundations;Generations;global health;Goals;Growth;Guidelines;Health;health goals;Healthcare Systems;HIV;Hybrids;implementation design;implementation determinants;implementation evaluation;implementation outcomes;implementation protocol;implementation research;implementation science;implementation strategy;Improve Access;improved;Incidence;Instruction;Interview;K-Series Research Career Programs;low and middle-income countries;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Maps;Mentors;Methods;mortality;Needs Assessment;Nurses;Nursing Education;Oncology;Outcome;Outcome Study;Patients;Pilot Projects;Positioning Attribute;Preparation;primary care clinic;primary care provider;primary health center;primary outcome;Process;Productivity;programs;Provider;Public Health;Qualifying;Quality of Care;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Methodology;Research Personnel;Research Proposals;Research Technics;Resources;routine care;Rwanda;scale up;Scientist;screening;screening guidelines;screening program;skills;South Africa;South African;Stage at Diagnosis;Structure;success;Surveys;survival disparity;Techniques;theories;Training;Universities;Woman;women's diagnosis;Work;World Health Organization

PROJECT_TITLE: Designing implementation strategies for introducing screening clinical breast examination to primary health centers in Johannesburg, South Africa

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Fundamental and translational studies have found that dysregulated immune responses are causally associated with intestinal infectious and inflammatory disorders. However, how the immune responses are regulated within the gut to promote intestinal health and prevent infection or inflammation remains elusive. A mechanistic understanding of the immune regulation in the gut is necessary for the development of novel preventative, therapeutic and curative strategies treating intestinal disorders and diseases.

PI_NAMEs: ZHOU, WENQING  (contact)

PROJECT_TERMS: Ablation;Acute;Address;Advisory Committees;Antigens;Area;Award;beneficial microorganism;Biological Assay;career;CCR6 gene;cell type;Cells;Chronic;Cleavage Under Targets and Release Using Nuclease;Coculture Techniques;Colon;Colorectal Cancer;Communicable Diseases;Communication;Data;Dendritic Cells;Development;dextran sulfate sodium induced colitis;dietary;Disease;Endothelial Cells;enteric infection;Exhibits;experience;Exposure to;fitness;fundamental research;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genetic;Genetic Risk;Genetic Transcription;Gnotobiotic;Goals;gut inflammation;Health;Health Promotion;Heterogeneity;Homeostasis;Human;Human Genome;Immune;Immune response;Immune system;Immunity;Immunomodulators;immunoregulation;in vivo;Infection;Infection prevention;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interleukin-10;Intestinal Diseases;Intestines;Knockout Mice;Knowledge;Laboratories;Link;Lymphocyte;Lymphoid Cell;Lymphoid Tissue;Mediating;Mediator;Mentors;Metabolic Diseases;microbiota;microbiota composition;Molecular;Mucosal Immunity;multidisciplinary;Mus;Nature;novel;novel therapeutic intervention;overexpression;pathogen;Pathogenesis;Pathway interactions;Patients;Permeability;Phase;Physiological;Property;Publishing;Regulation;Reporting;Research;Research Personnel;restraint;risk variant;Role;Scientific Advances and Accomplishments;Scientist;Shapes;Signal Transduction;single-cell RNA sequencing;Site;skills;Stimulus;Stromal Cells;Techniques;Testing;Therapeutic;Tissues;training opportunity;transcription factor;translational study;Work;Writing

PROJECT_TITLE: Defining a novel transcriptional regulator of intestinal health and inflammation


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: Project Narrative: A deeper understanding of mechanisms underlying periodontitis, a condition that affects 42% of the US adult population, will enhance management of a significant public health problem. This proposal is structured to test the hypothesis that periodontitis is the result of loss of host/microbiome homeostasis induced by excess inflammation that has direct actions on the composition and function of periodontal bacteria. By investigating host-microbiome interactions, we will identify specific targets and potential molecules for treating periodontal disease and breaking the inflammatory disease cycle. 1

PI_NAMEs: YU, NING  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acute;Adult;Advisory Committees;Affect;Air;Animal Model;animal tissue;Animals;Area;Automobile Driving;Back;Bacteria;Bacterial Genes;Binding;Bioinformatics;Biometry;bone loss;career;career development;Characteristics;Communities;Complex;Data;Dedications;Development;Discipline;Disease;Doctor of Philosophy;Dorsal;driving force;dysbiosis;Eicosanoids;Eicosapentaenoic Acid;Epithelium;Equilibrium;experience;Faculty;Family;Fluorescent in Situ Hybridization;Funding;Future;gain of function;Gene Expression;Genes;Geography;Goals;Histologic;Homeostasis;host microbiome;host-microbe interactions;Immune;immune activation;Immune response;Immune System Diseases;Immunology;improved;In Situ;In Vitro;Individual;Infection;Infection Control;Inflammation;Inflammatory;Inflammatory Response;Investigation;knockout animal;Knockout Mice;Knowledge;Lesion;Ligature;Link;lipid mediator;Liquid substance;Mediating;Mediator;medical schools;Mentors;Metabolic Pathway;metatranscriptomics;Methods;Microbe;microbial;Microbial Biofilms;microbial host;Microbiology;microbiome;microbiome analysis;microorganism interaction;Modeling;mouse model;Mus;Natural regeneration;neutrophil;novel;novel strategies;Omega-3 Fatty Acids;oral bacteria;Oral Characters;Oral health;oral microbiome;Organizational Change;overexpression;Pathogenesis;Pathway interactions;Periodontal Diseases;Periodontitis;Phase;Phenotype;Population;Positioning Attribute;prevent;programs;Public Health;receptor;Receptor Cell;Research;Research Design;Resistance;Resolution;restoration;Role;Sampling;Series;spectrograph;statistics;Structure;Subcutaneous Tissue;Symbiosis;System;tenure track;Testing;Time;Tissues;tool;Training;transcriptome;transcriptomics;Transgenic Animals;Transgenic Mice;Universities;Washington;Work

PROJECT_TITLE: From Symbiosis to Dysbiosis and Back: The Impact of Pro-Inflammation and Pro-Resolution

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The presence of high potency synthetic opioids (HPSO) in illicit opioid and other drug supplies presents a grave public health crisis and appears to be compromising the use of available treatments for those with opioid use disorder (OUD). Despite the ubiquity and persistence of HPSO, systematic evaluations of treatment in the HPSO era remain sparse and HPSO physiological dependence and withdrawal remain poorly characterized. Based on this gap in the literature, the primary goals of this mentored research development proposal are to compare buprenorphine formulations among those with OUD who use HPSO and to better characterize factors influencing successful initiation of and retention in treatment with an emphasis on quantitative HPSO levels and biomarkers (body weight, body fat percentage, and plasma buprenorphine/norbuprenorphine levels).

PI_NAMEs: LUBA, RACHEL R (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Abstinence;Admission activity;Adoption;Adult;Applications Grants;Automobile Driving;Back;Biological Factors;Biological Markers;Body fat;Body Weight;Buprenorphine;career;career development;Clinical;Clinical Trials;Conduct Clinical Trials;craving;Data;Data Analyses;Dedications;Dependence;design;Development;Dose;Dropout;Drug Kinetics;Evaluation;experience;follow-up;Formulation;Funding;Goals;Hour;Illicit Drugs;illicit opioid;improved;Individual;Individual Differences;Injectable;Injections;Inpatients;Laboratory Study;Life;liquid chromatography mass spectrometry;Literature;Measures;Medical center;medication for opioid use disorder;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Morphine;mu opioid receptors;naloxone dosing;New York;New York City;Opioid;Opioid agonist;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Outcome;Overdose;Participant;Pharmaceutical Preparations;Pharmacodynamics;Pharmacology;Pharmacotherapy;Physiological;Placebos;Plasma;Population;post-doctoral training;potential biomarker;Proliferating;Psychologist;Public Health;Publishing;Randomized;Randomized, Controlled Trials;Relapse;Research;research and development;Research Personnel;response;Sampling;Schedule;secondary analysis;Severities;sex;Suboxone;Substance Use Disorder;substance use treatment;synthetic opioid;Time;timeline;Titrations;Toxicology;Training;treatment adherence;Treatment outcome;treatment response;Universities;Urine;Visit;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: A Randomized Controlled Trial Examining Extended-Injectable Buprenorphine in those who use High Potency Synthetic Opioids

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Social Determinants of Health

PHR: PROJECT NARRATIVE Preterm infants are at risk for impaired language development due to physiologic insults, white matter injury, and the atypical auditory environment of the Neonatal Intensive Care Unit. The purpose of the proposed work is to investigate the influence of the auditory environment on attention to and auditory recognition memory for maternal voice as well as auditory cortex development in premature infants and fetuses subsequently born at term while accounting for variables known to impact language development. The ultimate goal of this work is to apply these findings to the design and implementation of interventions in the Neonatal Intensive Care Unit, which promote experience-dependent plasticity and improve the long-term outcomes of premature infants.

PI_NAMEs: HAMMOND, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: 37 weeks gestation;Acceleration;Address;Adolescence;Affect;Age;Attention;Auditory;Auditory area;auditory processing;auditory stimulus;Award;Birth;Brain;brain behavior;Brain region;Characteristics;Clinical;critical period;Data;Deceleration;design;Development;Electroencephalography;Ensure;Environment;Etiology;Event-Related Potentials;experience;Exposure to;fetal;Fetus;Foundations;Functional Magnetic Resonance Imaging;Gestational Age;Goals;Heart Rate;Hippocampus;Home;Human;Impairment;implementation intervention;improved;improved outcome;in utero;indexing;Infant;Institution;interest;Intervention;Knowledge;Language;Language Development;language impairment;language outcome;Longitudinal Studies;maternal depression;maternal stress;Measures;Medical;Memory;memory recognition;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Neonatal Intensive Care Units;neonatal morbidity;Neonatology;neurobehavior;neurobehavioral;neurodevelopment;neuroimaging;neurophysiology;Neurosciences;neurosensory;Outcome;Physicians;Physiological;Prefrontal Cortex;Pregnancy;Pregnant Women;premature;Premature Infant;Prematurity of fetus;Prospective Studies;recruit;Research;response;Rest;Risk;Scientist;Sensory;sex;Socioeconomic Status;sound;sound frequency;Speech;Speech Sound;Stimulus;Survival Rate;sustained attention;Systems Analysis;Thalamic structure;therapy design;Training;United States;Voice;white matter injury;Work

PROJECT_TITLE: The Impact of the Auditory Environment on Auditory Processing of Maternal Voice and Auditory Cortex Maturation in Preterm and Term Infants

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]