NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Rare Diseases;Vaccine Related

PROJECT_TERMS: African Green Monkey;Amendment;Antibodies;Antibody Response;B-Lymphocytes;Binding;Biological Assay;candidate identification;Cessation of life;Chimeric Proteins;Coma;Development;Disease;Dose;Enzyme-Linked Immunosorbent Assay;experimental study;Follow-Up Studies;Frequencies;Glycoproteins;Immune;Immune response;Immunologic Tests;International;Licensing;Link;Messenger RNA;monomer;Nipah Virus;Phase I Clinical Trials;Phenotype;Pilot Projects;programs;Reporting;RNA vaccine;Specificity;T cell response;Testing;Time;vaccine candidate;vaccine-induced antibodies;Vaccines;Virus;Virus Diseases;World Health Organization

PROJECT_TITLE: Development of Nipah virus mRNA vaccine


ACTIVITY: ZIA

ADMINISTERING_IC: TR

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Endocrine Disruptors

PI_NAMEs: XIA, MENGHANG  (contact)

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Acrylates;Active Sites;Adult;Advocate;Affinity;Aftercare;Agonist;All-Trans-Retinol;Androgen Receptor;Animal Testing;antagonist;Binding;Biochemical;Biochemical Pathway;Biological;biological adaptation to stress;Biological Assay;Biological Process;biological systems;Biomedical Engineering;Biotechnology;Brain;Carbachol;Cell Differentiation process;cell dimension;Cell Survival;Cells;Chemicals;Cholinergic Agonists;Collaborations;computational toxicology;consumer product;Consumption;Cosmetics;counterscreen;CYP26B1 gene;CYP2C9 gene;Cysteine;Cytochrome P450;cytokine;Data;design;Docking;Dose;drug metabolism;Elements;Endocrinology;Environment;environmental chemical;environmental toxicology;Enzyme Inhibitor Drugs;Enzymes;Epithelium;ESR1 gene;Evaluation;Exhibits;Exposure to;Family;Fatty Acids;Fetal Development;Follow-Up Studies;FOS gene;frontier;Genes;Genomics;GNRH1 gene;Goals;Hazardous Substances;Health;High Pressure Liquid Chromatography;high throughput screening;Homeostasis;Human;Human Cell Line;Hypothalamic structure;IL8 gene;In Vitro;in vitro Assay;in vivo;induced pluripotent stem cell;inhibitor;irritation;Isomerism;Journals;JUN gene;KISS1 gene;Larva;Leadership;Libraries;Ligands;Lysine;Manuscripts;Mass Spectrum Analysis;Measures;Mediating;Metabolism;meter;methacholine;Methods;Microsomes;miniaturize;Mission;Mitotic Cell Cycle;Modeling;Molecular;Monitor;monolayer;Mus;nanomolar;National Center for Advancing Translational Sciences;National Health and Nutrition Examination Survey;National Institute of Environmental Health Sciences;Neurons;Non-Steroidal Anti-Inflammatory Agents;novel;Nuclear Receptors;Occupations;orphan nuclear receptor ROR-gamma;Outcome;Pathway interactions;Peptides;Persons;Pharmaceutical Preparations;Pituitary Gland;Play;Poly-fluoroalkyl substances;PPAR alpha;predictive modeling;programs;Protein Isoforms;Publishing;receptor;Receptors, Adrenergic, beta-1;Reporting;Reproduction;Research Personnel;response;retinoic acid 4-hydroxylase;Retinoic Acid Receptor;Retinoids;robotic system;Role;Safety;screening;screening program;Serum;Signal Transduction;Skin;Specificity;steroid hormone;substance use;System;Testing;Thick;Tight Junctions;Time;Topical application;Toxic effect;Toxicology;Tretinoin;United States Environmental Protection Agency;United States Food and Drug Administration;United States National Institutes of Health;Validation;Vitamin A;Vitamin K;Work;Zebrafish

PROJECT_TITLE: Toxicology in the 21st Century Program (Tox21) - Systems Toxicology


ORG_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PI_NAMEs: GERHOLD, DAVID  (contact)

PROJECT_TERMS: 3-Dimensional;Adverse effects;Affect;anakinra;Animal Testing;Anti-Inflammatory Agents;Atherosclerosis;base;Biochemical Pathway;biochip;Biological;biological adaptation to stress;Biological Assay;biological systems;Blood Platelets;Blood Vessels;Canis familiaris;cardiovascular health;Cardiovascular system;Cell Culture Techniques;Cell Line;Cell model;Cells;Chemicals;Coagulation Process;Coculture Techniques;Collaborations;computational toxicology;Consumption;CYP1A1 gene;CYP1B1 gene;cytokine;design;Development;Drug Combinations;drug development;Drug resistance;Drug Targeting;Endothelial Cells;Environment;environmental chemical;Ephedra;Etanercept;Evaluation;Failure;fluid flow;Gene Expression;Genomics;Goals;Health;Heart;Human;human disease;improved;In Vitro;in vivo;Inflammation;Inflammatory;innovation;Libraries;Luciferases;Measures;Metals;Methods;Mission;Modeling;Myocardial Infarction;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;National Toxicology Program;Neoplasm Metastasis;Neurodegenerative Disorders;Neurons;neurotoxicity;new technology;Oxidative Stress;Parkinson Disease;Pathway interactions;Patients;Pharmaceutical Preparations;Poison;predictive modeling;programs;Reporter;resistance mechanism;response;screening;stem cell differentiation;System;Technology;Testing;Therapeutics for Rare and Neglected Diseases;Time;Tissue Model;Toxic effect;Toxic Environmental Substances;toxicant;Toxicology;transcriptomics;translation to humans;Tumor necrosis factor receptor 11b;tumorigenesis;United States Environmental Protection Agency;United States Food and Drug Administration;Vascular Endothelial Cell;Work

PROJECT_TITLE: Toxicology in the 21st Century Program (Tox21) - Genomic Toxicology


PI_NAMEs: HUANG, RUILI  (contact)

PROJECT_TERMS: 2019-nCoV;Adverse drug effect;Affect;Algorithmic Software;Algorithms;Analytical Chemistry;Animal Testing;Animals;Anti-viral Agents;Area;Auranofin;Biochemical Pathway;Biological;Biological Assay;biological systems;Biology;Cardiotoxicity;Cells;Charge;Chemical Exposure;Chemical Structure;Chemicals;Classification;Clinical Trials;Collaborations;Communication;computational toxicology;Computer Models;computerized data processing;Consumption;curve fitting;Data;Data Analyses;data pipeline;Data Set;design;Development;drug induced liver injury;drug repurposing;Eligibility Determination;environmental chemical;Evaluation;Exposure to;Follow-Up Studies;Food;Gene Expression;Genes;genetic linkage analysis;genome-wide linkage;Genomics;Goals;Health;high throughput screening;Household;Human;improved;In Vitro;in vivo;in vivo Model;Informatics;Leadership;Libraries;Machine Learning;Malaria;Manuscripts;Maryland;Measures;medical schools;medical specialties;Medicine;Methods;Mission;Modeling;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;National Institute of Environmental Health Sciences;National Toxicology Program;Nature;neurotoxicity;novel;olfactory receptor;Online Systems;Paper;Parasitic infection;Pathway interactions;Performance;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;preclinical study;predictive modeling;Preparation;programs;Proteomics;PubChem;Public Health;Publications;Publishing;Rare Diseases;Reproducibility;Research;Research Personnel;response;Safety;Scientist;screening;Software Tools;Structure-Activity Relationship;System;Testing;Time;tool;Toxic effect;Toxicology;United States Environmental Protection Agency;United States Food and Drug Administration;United States National Institutes of Health;United States National Library of Medicine;Universities;Update;Viral;Visualization;Water;web site;Work

PROJECT_TITLE: Toxicology in the 21st Century Program (Tox21) - Computational Toxicology


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eating Disorders;Mental Health;Nutrition;Substance Misuse

PI_NAMEs: MARUGAN, JUAN  (contact)

PROJECT_TERMS: absorption;addiction;Addictive Behavior;analog;Animal Model;Behavioral;Behavioral Assay;beta-arrestin;Binding;Biochemical;Biological Assay;biophysical techniques;Characteristics;Clinical;clinical candidate;Collaborations;Cryoelectron Microscopy;Development;Docking;Drug Addiction;drug discovery;Drug or Chemical;drug testing;Eating;Eating Disorders;Endosomes;Evaluation;Excretory function;G-Protein-Coupled Receptors;Gene Modified;ghrelin;ghrelin receptor;GHS-R1a;Goals;GTP-Binding Proteins;humanized mouse;improved;in silico;in vivo;Laboratories;Lead;lead optimization;lead series;Ligands;Measures;Metabolic;Metabolism;Modeling;molecular modeling;Mus;Mutagenesis;novel therapeutic intervention;Outcome;pharmacologic;Pharmacology;Physiological;pre-clinical;Production;Property;protein activation;Proteins;receptor;recruit;Signal Transduction;small molecule;Structure-Activity Relationship;tool;trafficking;Validation

PROJECT_TITLE: Identification of small molecule that selectively modulate Ghrelin receptor (GHSR1a) b-arrestin signaling as a new therapeutic approach for the treatment of addiction


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Diabetes;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: TRISTAN, CARLOS  (contact)

PROJECT_TERMS: Absence of pain sensation;Address;Adult;Afferent Neurons;Alexander Disease;Amyotrophic Lateral Sclerosis;Area;Astrocytes;Baltimore;Basic Science;bean;Biomanufacturing;Cell Aggregation;cell community;Cell Differentiation process;Cell Line;Cell Survival;Cell Therapy;cell type;Cells;Chemotherapy-induced peripheral neuropathy;Clinical;clinical application;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Communities;County;Cryopreserved Cell;Cultured Cells;diabetic;differentiation protocol;Disease;disease model;dopaminergic neuron;drug development;Educational workshop;Electrophysiology (science);Embryoid bodies;fitness;Funding;gene-editing approach;Genetic;Genetic Screening;genome editing;Goals;Hepatocyte;human induced pluripotent stem cells;Hypothalamic structure;improved;induced pluripotent stem cell;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Laboratories;Laboratory Scientists;Liver Failure;Manuscripts;Maryland;Medicine;meetings;Metabolic Diseases;Methods;Modeling;Motor Neurons;multiple omics;National Center for Advancing Translational Sciences;National Human Genome Research Institute;Nervous System Disorder;Neuroglia;Neuronal Differentiation;Neurons;Nociceptors;Non-Insulin-Dependent Diabetes Mellitus;novel;Opioid;Oranges;Organoids;Paper;Paris, France;Parkinson Disease;patient derived induced pluripotent stem cells;Pediatric Hospitals;Peripheral;Peripheral Nervous System Diseases;Phase;Placentation;pluripotency;pluripotent stem cell differentiation;Pluripotent Stem Cells;preclinical development;programs;Publishing;Quality Control;Reagent;Recombinant Proteins;Regenerative Medicine;reproductive system disorder;Research;Robotics;Sialic Acids;small molecule;stem cell biology;Stem Cell Research;stem cell therapy;stem cells;Stress;symposium;Testing;Therapeutic;therapeutic genome editing;transcriptomics;translational applications;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;Variant;virtual;Visit;webinar

PROJECT_TITLE: Stem Cell Translation Laboratory (SCTL)


ACTIVITY: ZIB

ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vaccine Related - AIDS;Vector-Borne Diseases

PI_NAMEs: GALL, JASON  (contact)

PROJECT_TERMS: Adjuvant;Area;Biological Products;Buffers;Clinic;Clinical;clinical material;Clinical Trials;Conjugate Vaccines;Dedications;Development;Ebola Vaccines;Equipment;Facility Designs;Good Manufacturing Process;HIV;HIV vaccine;Human;Influenza;Influenza A Virus, H5N1 Subtype;influenza virus vaccine;Laboratories;large scale production;Malaria;manufacture;manufacturing facility;manufacturing process;Marburgvirus;Monoclonal Antibodies;nanoparticle;National Institute of Allergy and Infectious Disease;next generation;operation;pandemic influenza;Peptides;Phase I/II Clinical Trial;Placebos;Plants;Process;programs;Proteins;Quality Control;Respiratory Syncytial Virus Vaccines;Techniques;Testing;United States Food and Drug Administration;universal influenza vaccine;vaccine evaluation;Vaccine Production;vaccine-induced antibodies;Vaccines;Vial device;Work;Zika virus vaccine

PROJECT_TITLE: Establishment and operation of a Vaccine Pilot Plant


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Nanotechnology;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Clinic;clinical material;Clinical Research;Clinical Trials;Dedications;Development;Effectiveness;Evaluation;Future;Good Manufacturing Process;Human;Human Volunteers;Immunity;influenza virus strain;influenza virus vaccine;Laboratories;large scale production;manufacture;manufacturing facility;manufacturing process;Monitor;nanoparticle;National Institute of Allergy and Infectious Disease;Phase;Phase I/II Clinical Trial;Placebos;Production;programs;Safety;Seasons;Techniques;Testing;universal influenza vaccine;vaccine immunogenicity;Vaccine Production;Vaccines;Virus

PROJECT_TITLE: Development/production of universal influenza vaccines


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: analytical method;assay development;Biological Products;Biological Response Modifier Therapy;Biotechnology;cell bank;cGMP production;Clinical;clinical application;clinical material;Clinical Trials;Contracts;Democratic Republic of the Congo;Development;Disease Outbreaks;Documentation;Ebola;Formulation;HIV Antibodies;HIV-1;improved;Industry;interest;Laboratories;Licensing;lot production;manufacture;manufacturing process;manufacturing test;Methods;Monoclonal Antibodies;neutralizing antibody;neutralizing monoclonal antibodies;Pathway interactions;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Plants;Process;Production;programs;Protocols documentation;Public Health;Randomized, Controlled Trials;Research;Services;stability testing;Therapeutic;Therapeutic antibodies;Toxicology;vaccine development;Vaccine Production;Vaccines

PROJECT_TITLE: Production of a Broadly Neutralizing HIV Antibodies


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Immunization;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: analytical method;Anti-malarials;Antibodies;assay development;Biotechnology;Buffers;cell bank;cGMP production;Clinical;clinical application;clinical material;Clinical Trials;Contracts;COVID-19 pandemic;Development;Documentation;Dose;Enrollment;Formulation;Human;improved;Industry;Infection prevention;Investigational New Drug Application;Kenya;Laboratories;Malaria;malaria infection;Malaria prevention;Mali;manufacture;manufacturing process;manufacturing test;Methods;Monoclonal Antibodies;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Phase I Clinical Trials;Phase II Clinical Trials;Plants;Process;Production;Productivity;programs;Research;Route;stability testing;Therapeutic Monoclonal Antibodies;Toxicology;vaccine development;Vaccine Production;Vaccines

PROJECT_TITLE: Development and Production of Anti-Malarial Biologicals


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adjuvant;aluminum sulfate;Antibodies;Carbopol;Clinic;clinical material;Clinical Trials;Dedications;Development;Evaluation;Good Manufacturing Process;HIV;HIV vaccine;HIV-1;Human;Human Volunteers;Immunity;immunogenicity;improved;Joints;Laboratories;large scale production;Lecithin;manufacture;manufacturing facility;manufacturing process;National Institute of Allergy and Infectious Disease;Peptides;Phase;Phase I/II Clinical Trial;Placebos;Process;Production;programs;Protein Subunits;Recombinants;Safety;Sterilization;Subunit Vaccines;Techniques;Technology Transfer;Testing;Tetanus Toxoid;Vaccine Design;vaccine immunogenicity;Vaccine Production;Vaccines

PROJECT_TITLE: Development and Production of HIV Vaccines and Adjuvants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;betacoronavirus;Biological Products;Clinic;clinical material;Clinical Trials;Collaborations;coronavirus vaccine;Dedications;Development;Evaluation;Good Manufacturing Process;Human;Human Volunteers;Immunity;influenza virus vaccine;Laboratories;large scale production;manufacture;manufacturing facility;manufacturing process;National Institute of Allergy and Infectious Disease;Phase;Phase I/II Clinical Trial;Placebos;Production;programs;Proteins;Reagent;Research;RNA vaccine;Safety;Techniques;Testing;vaccine immunogenicity;Vaccine Production;Vaccines;Variant

PROJECT_TITLE: Development and Production of SARS-CoV2 Biologicals and Vaccines


ACTIVITY: ZIC

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: CHENG, CHENG  (contact)

PROJECT_TERMS: Adjuvant;Affinity;aluminum sulfate;Animal Model;Animals;Antibodies;Antibody Response;Antigens;Autologous;base;Binding Sites;Biological Assay;biophysical properties;Biotechnology;Carrier Proteins;Categories;Cavia;Cells;Chimeric Proteins;Clinical;clinical development;clinical predictors;Clinical Trials;Collaborations;Data;design;Development;Dose;Drug Kinetics;env Gene Products;Evaluation;flexibility;Generations;glycosylation;Half-Life;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;human monoclonal antibodies;Immune;Immune response;Immunize;immunogenicity;Immunoglobulin G;improved;in vivo;Infection;Link;manufacturability;Methods;Monkeys;mouse model;Mus;Mutation;nanoparticle;neoantigens;neonatal Fc receptor;neutralizing antibody;next generation;nonhuman primate;novel;novel vaccines;Outcome;Pathway interactions;Patients;Peptide antibodies;Peptide Vaccines;Peptides;Peripheral Blood Mononuclear Cell;Phase I Clinical Trials;Polysaccharides;Population;preclinical study;predictive tools;Prevention;Preventive;Proteins;rational design;Regimen;Research;Resistance;response;RNA vaccine;Route;safety testing;Serum;simian human immunodeficiency virus;Site;Specificity;structural biology;Structure;Surface;T-Lymphocyte;Testing;Therapeutic;Transgenic Mice;Transmembrane Domain;Treatment Efficacy;Vaccination;vaccine candidate;vaccine evaluation;vaccine strategy;Vaccines;Variant;Viral;viral resistance;Virus;Virus Diseases;Work

PROJECT_TITLE: HIV/AIDS Vaccine and Antibody Development


PI_NAMEs: DORIA-ROSE, NICOLE  (contact)

PROJECT_TERMS: Animals;Antibodies;antibody engineering;antibody test;Biological Assay;candidate selection;clinical candidate;Clinical Trials;Data;Data Analyses;Genes;HIV;HIV Antibodies;HIV vaccine;HIV-1;Immune response;Immunology procedure;improved;Individual;Industry Collaboration;Infection;Infrastructure;Liquid substance;manufacturability;mutant;National Institute of Allergy and Infectious Disease;neutralizing antibody;Persons;Protocols documentation;Reagent;Robotics;Role;Running;Sampling;Serum;Services;Standardization;Vaccinated;Vaccine Research;Vaccines;Variant;Virus;Work

PROJECT_TITLE: Quantitative Immunological Assays to Assess HIV Antibodies and Vaccines


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: PERFETTO, STEPHEN  (contact)

PROJECT_TERMS: antibody conjugate;Basic Science;Cell Separation;Cells;Clinical;Clinical Trials;Collaborations;Color;Communities;Complex;Computers and Advanced Instrumentation;Core Facility;COVID-19 pandemic;Data Analyses;Data Collection;design;Detection;detector;Development;Dimensions;Dyes;Emerging Communicable Diseases;Ensure;Environment;experimental study;Flow Cytometry;Fluorochrome;Immunology;instrument;instrumentation;Laboratories;Lasers;Maintenance;Manufacturer;Measures;multidimensional data;nanocrystal;National Institute of Allergy and Infectious Disease;novel;operation;Optics;Performance;Procedures;programs;quality assurance;Quality Control;Reagent;Research;Research Personnel;Robotics;Role;Running;Sampling;Schedule;Services;Software Tools;Specimen;Speed;Techniques;Technology;tool;Training;vaccine development;Vaccine Research;Validation;Viola;Work

PROJECT_TITLE: Flow Cytometry Core


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: FOULDS, KATHRYN  (contact)

PROJECT_TERMS: Adjuvant;Animal Care and Use Committees;Animals;Basic Science;Biological Assay;Cell Separation;Clinical;Collaborations;Contracts;Cryopreserved Cell;Data;Data Analyses;design;Ensure;Evaluation;experimental study;Flow Cytometry;Generations;good laboratory practice;Human;IACUC;immune function;immunogenicity;Immunologics;International;Laboratories;Laboratory Animal Medicine;Laboratory Research;Lymphocyte;lymphocyte trafficking;Maintenance;Memory;Methods;Modeling;mucosal site;Mucous Membrane;nonhuman primate;operation;Oral;Pathogenesis;Practice Guidelines;preclinical study;Preclinical Testing;Procedures;Protocols documentation;Qualifying;Reproducibility;Research Personnel;research study;Research Support;response;sample collection;Schedule;Site;SIV;Specimen;Specimen Handling;Technology;Testing;Tissues;Training;Translational Research;translational study;Translations;Vaccination;vaccine evaluation;Vaccine Research;vector;Virus Diseases;Writing

PROJECT_TITLE: Non-Human Primate Core


NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: SHEN, CHEN-HSIANG  (contact)

PROJECT_TERMS: 2019-nCoV;Adsorption;Antibodies;Antibody Response;Antigens;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Computational Biology;computerized tools;design;Development;Elements;Epitopes;Evaluation;experimental study;flexibility;General Population;genomic locus;Glycoproteins;Goals;Hepatitis B Virus;HIV-1;Immune system;improved;Individual;Infection;insight;Macaca;Membrane;neutralizing antibody;next generation sequencing;novel;pathogen;pathogenic virus;Pathway interactions;Patients;Peptides;physical property;Play;Process;Proteins;response;Role;SARS-CoV-2 spike protein;Serology;Serum;Specificity;structural biology;Structure;Surface;Techniques;Therapeutic;tool;Vaccinated;Vaccination;Vaccinee;Vaccines;Variant;Viral;Virus;virus core

PROJECT_TITLE: Design of Antigenically-Specific Probes for Sera Analysis and MAb Isolation


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: RAWI, REDA  (contact)

PROJECT_TERMS: Architecture;Bioinformatics;Biological;Characteristics;Comprehension;computerized tools;Computing Methodologies;Cryoelectron Microscopy;Crystallization;Data;disulfide bond;Epitopes;flexibility;glycosylation;Homology Modeling;Hydrophobicity;Investigation;Link;Membrane Proteins;Methods;Modeling;Molecular;molecular dynamics;Play;Process;Protein Engineering;protein structure;Proteins;Research;Role;Sequence Analysis;Site;Solvents;Structure;Techniques;Vaccine Design;Viral;Viral Antigens;Viral Proteins

PROJECT_TITLE: Computational Tools for Structural Analysis


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Antibodies;Antibody Response;Antigens;Binding;Cholesterol;Computing Methodologies;design;Development;Engineering;Ensure;Epitopes;Half-Life;Human;human pathogen;Immune response;Immunization;Immunize;immunogenicity;in silico;inhibiting antibody;iterative design;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Macaca fascicularis;Membrane Proteins;Methodology;Methods;Molecular Conformation;mouse model;Myocardial Infarction;Plasma Proteins;Positioning Attribute;Prevention;Proprotein Convertases;Proteins;Regulation;Research;Resistance;scaffold;Serum;Site;Structure;Subtilisins;tool;Vaccination;vaccine efficacy;vaccine response;vaccine strategy;Vaccines;Variant;Viral

PROJECT_TITLE: Rational Immunogen Design Using Computational Methods


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: DOUEK, DANIEL CESAR (contact)

PROJECT_TERMS: Antibodies;antibody conjugate;Antigens;B-Lymphocytes;Cavia;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chromium;Clinical Research;Custom;design;Evolution;Genes;genome analysis;Genomics;Goals;HIV;Human;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulins;Immunology;Infectious Agent;influenza virus vaccine;Libraries;Macaca fascicularis;Macaca mulatta;Malaria Vaccines;Methodology;microbiome sequencing;Molecular;Monitor;mRNA sequencing;Mus;neutralizing antibody;next generation sequencing;passive antibodies;Persons;programs;Proteomics;Protocols documentation;Research Project Grants;Respiratory Syncytial Virus Vaccines;Sampling;Series;Specialist;T cell receptor repertoire sequencing;targeted sequencing;Techniques;Testing;transcriptome sequencing;Tuberculosis Vaccines;vaccine candidate;vaccine effectiveness;vaccine evaluation;Vaccine Research;Variant

PROJECT_TITLE: The Genome Analysis Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS

PROJECT_TERMS: Accounting;Address;Algorithms;Antibodies;Antibody Binding Sites;antigen binding;Antigens;Binding;Bioinformatics;Characteristics;combinatorial;Complex;Computational algorithm;Computational Biology;Computer Assisted;Data;design;Development;Effectiveness;Evaluation;flexibility;HIV-1;Immune;improved;Investigation;Ligands;machine learning classifier;Methodology;Methods;Modeling;novel;Post-Translational Protein Processing;Process;Property;Protein Engineering;Protein Glycosylation;protein structure;Proteins;Protocols documentation;Quaternary Protein Structure;Scaffolding Protein;structural biology;success;Techniques;Technology;tool;Transplantation;Virus

PROJECT_TITLE: Computational Algorithms, Methods, and Tools for Antibody Design


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

PI_NAMEs: KONG, WING PUI  (contact)

PROJECT_TERMS: 2019-nCoV;aged;Antibodies;Antibody Response;Collaborations;combat;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 vaccine;Development;DNA;FDA Emergency Use Authorization;future outbreak;Genetic;Hepatitis B Surface Antigens;Human;Immunization;Laboratories;Length;Mus;nanoparticle;National Institute of Allergy and Infectious Disease;neutralizing antibody;pandemic disease;pre-clinical;prevent;Proline;RNA vaccine;Sarbecovirus;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Vaccinee;Vaccines;virology

PROJECT_TITLE: Pre-clinical Vaccine and Antibody Development for Coronavirus Disease 2019 (COVID-19)


NIH_SPENDING_CATS: Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

PROJECT_TERMS: Adjuvant;Animal Care and Use Committees;Animals;Basic Science;Biological Assay;Cell Separation;Clinical;Collaborations;Contracts;COVID-19;Cryopreserved Cell;Data;Data Analyses;design;Ensure;Evaluation;experimental study;Flow Cytometry;Generations;good laboratory practice;Human;IACUC;immune function;immunogenicity;Immunologics;International;Laboratories;Laboratory Animal Medicine;Laboratory Research;Lymphocyte;lymphocyte trafficking;Maintenance;Memory;Methods;Modeling;mucosal site;Mucous Membrane;nonhuman primate;operation;Oral;Pathogenesis;Practice Guidelines;preclinical study;Preclinical Testing;Procedures;Protocols documentation;Qualifying;Reproducibility;Research Personnel;research study;Research Support;response;sample collection;Schedule;Site;Specimen;Specimen Handling;Technology;Testing;Tissues;Training;Translational Research;translational study;Translations;Vaccination;vaccine evaluation;Vaccine Research;vector;Virus Diseases;Writing

PROJECT_TITLE: Non-Human Primate Core for COVID Effort


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Rare Diseases

PI_NAMEs: CHENG, KEN  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Adaptive Immune System;Address;Adverse effects;Algorithmic Analysis;Area;assay development;Automation;Awareness;Bacteria;Bacteriophages;Binding;Biological Assay;Biological Process;Biology;Biotechnology;Cells;Cellular biology;cellular imaging;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communicable Diseases;Complex;computerized tools;CRISPR interference;CRISPR library;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Analyses;Databases;Development;Devices;Diabetes Mellitus;Disease;DNA;DNA biosynthesis;DNA Double Strand Break;DNA Sequence;Drug Targeting;Ebola virus;Education and Outreach;Effectiveness;Enhancers;experimental study;Fragile X Syndrome;functional genomics;Gene Expression;gene function;Genes;genetic corepressor;genetic element;Genetic Recombination;Genetic Screening;Genetic Transcription;Genome;genome editing;genome-wide;genomic locus;Goals;Health;Hepatitis C virus;HIV;Human;Incidence;Informatics;inhibitor;innovation;interest;Intramural Research Program;knock-down;Knock-in;knockout gene;Laboratories;Libraries;Life;loss of function;Malignant Neoplasms;Methodology;Methods;MicroRNAs;Mission;Molecular Target;Mutation;National Center for Advancing Translational Sciences;Nematoda;Neoplasm Metastasis;new technology;nuclease;Parkinson Disease;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;pre-clinical;Private Sector;Process;Prokaryotic Cells;PubChem;public database;Reading;recruit;repaired;Research Personnel;Resistance;Resource Sharing;reverse genetics;RNA;RNA Interference;RNA interference screen;RNA Sequences;Robotics;Role;Science;Scientist;screening;small hairpin RNA;Small Interfering RNA;small molecule;System;Techniques;Technology;Testing;Time;tool;United States National Institutes of Health;United States National Library of Medicine;Validation;Virus Diseases;Virus Replication;Work;Zika Virus

PROJECT_TITLE: Functional Genomics Laboratory (FGL)


ACTIVITY: ZID

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: ANDREWS, SARAH  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Accreditation;assay development;B-Lymphocytes;Binding;Biological Assay;Clinical;clinical investigation;Collaborations;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 vaccine;data exchange;Development;Documentation;efficacy trial;Emerging Communicable Diseases;emerging pathogen;Enzyme-Linked Immunosorbent Assay;Equipment;Generations;Goals;Human Resources;Immune;Immunobiology;Immunocompromised Host;immunogenicity;Immunology;improved;Individual;Industry;instrumentation;interest;Investigation;Laboratories;Licensure;Maintenance;Manuscripts;mucosal vaccine;National Institute of Allergy and Infectious Disease;operation;Pharmaceutical Preparations;Phase;phase 1 testing;Phase III Clinical Trials;phase III trial;Pre-Clinical Model;programs;Proteins;Protocols documentation;Public Health;Publishing;Qualifying;Readiness;Regimen;Reporting;Research;response;Sampling;SARS-CoV-2 transmission;screening;Serology;Speed;Standardization;T-Lymphocyte;Technology Transfer;Testing;Therapeutic;Vaccine Clinical Trial;vaccine development;vaccine distribution;vaccine efficacy;vaccine evaluation;Vaccines;Validation;Variant;variants of concern

PROJECT_TITLE: COVID-19 Clinical Support and Research


ACTIVITY: ZIG

PI_NAMEs: ROEDERER, MARIO  (contact)

PROJECT_TERMS: animal care;Animal Care and Use Committees;animal resource;Animals;Caring;Development;Infrastructure;Laboratory Animals;Medicine;Monitor;operation;Policies;Principal Investigator;programs;Regulation;Research;Research Support;translational research program;Vaccine Research

PROJECT_TITLE: Animal Medicine Infrastructure Support - Animal Care


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: Accreditation;Agreement;Alpha Virus;Analgesics;Anesthesia procedures;animal care;Animal Care and Use Committees;animal facility;Animal Husbandry;Animal Model;animal model development;Animals;biodefense;Blood;Breeding;Caring;Clinical Trials;Collaborations;Collection;Consultations;Contracts;COVID-19;Development;Disease;Educational process of instructing;Electroporation;Emerging Communicable Diseases;Ensure;good laboratory practice;Guidelines;Human;in vivo;Influenza;Injections;Institution;Laboratory Animals;Medicine;Methods;model development;Modeling;Monitor;Mus;novel;novel vaccines;operation;Operative Surgical Procedures;Oral Administration;Policies;pre-clinical;preclinical safety;Preparation;Preventive medical care;Principal Investigator;Procedures;product development;programs;quality assurance;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Safety;Serum;Services;Tissues;Toxicology;Training;Translational Research;translational research program;vaccine delivery;vaccine efficacy;Vaccine Research;Vaccines;Vendor

PROJECT_TITLE: Animal Medicine COVID Support


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: VEAZEY, RONALD  (contact)

PROJECT_TERMS: AIDS prevention;AIDS Vaccines;Breeding;clinical efficacy;cross reactivity;Development;Evaluation;evaluation/testing;flexibility;HIV;HIV Envelope Protein gp120;HIV vaccine;Housing;Immune response;immunogenicity;Maintenance;Modality;Modeling;Mucosal Immune Responses;National Institute of Allergy and Infectious Disease;neutralizing antibody;nonhuman primate;Peptides;preclinical evaluation;preclinical study;prevent;Prevention Research;Prevention strategy;programs;Regimen;research clinical testing;Research Personnel;Resources;Risk;Site;Testing;United States National Institutes of Health;vaccine efficacy;vaccine evaluation;vaccine platform;Vaccine Research;Vaccines;Virus;Virus Diseases

PROJECT_TITLE: Assessment of Heterologous Prime-boost HIV Vaccine Regimen to Elicit Cross-reactive Neutralizing Antibodies Targeting HIV Fusion Peptide


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Allogenic;Animal Model;Autologous;Biological Assay;cancer therapy;Cell Therapy;cell type;Cells;Cellular immunotherapy;Chemotherapy and/or radiation;chimeric antigen receptor T cells;Clinical;clinical application;clinical efficacy;clinical research site;Clinical Trials;Collaborations;Complex;Credentialing;Cyclic GMP;Dendritic Cells;Discipline;engineered T cells;Engineering;fitness;Fostering;Funding;Hematologic Agents;Hematologic Neoplasms;Hematopoietic stem cells;high standard;Human;Immune;Immunotherapy;induced pluripotent stem cell;innovation;Institution;leukemia;Lymphocyte;Lymphoma;Macrophage;Malignant Neoplasms;manufacture;manufacturing process;member;Mesenchymal;Mesenchymal Stem Cells;Multi-site clinical study;Multiple Myeloma;Normal tissue morphology;novel;paracrine;Patients;Pharmaceutical Preparations;pilot trial;preservation;Radiation induced damage;rare cancer;Research;Research Personnel;Resources;Safety;Science;Site;Solid Neoplasm;Standardization;stem cell therapy;Study models;success;T-Cell Receptor;T-Lymphocyte;Therapeutic;tissue stem cells;Tissues;tumor;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Work

PROJECT_TITLE: CORE SUPPORT FOR THE IMMUNE CELL NETWORK


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

PI_NAMEs: MANDACI, OGUZ  (contact)

PROJECT_TERMS: Architecture;archived data;Archives;Biological Specimen Banks;Communication;Data;data archive;Data Collection;data de-identification;data dissemination;data sharing;design;diverse data;Ensure;Equipment and supply inventories;FAIR principles;flexibility;Funding;Human;National Institute of Child Health and Human Development;Participant;Process;repository;Research;Research Personnel;research study;Residual state;Resources;secondary analysis;Services;Site;Specimen

PROJECT_TITLE: REPOSITORY SERVICES FOR THE NICHD DATA AND SPECIMEN HUB (DASH)


NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

PROJECT_TERMS: adverse pregnancy outcome;Aliquot;Arteries;Bar Codes;California;clinical research site;Collection;Data Coordinating Center;demographics;DNA;Enrollment;Ensure;Equipment and supply inventories;Etiology;Evaluation;Family;Fetal Growth;Fetal Growth Retardation;First Pregnancy Trimester;Indiana;International;Intervention;Label;maternal serum;Measurement;Measures;Medical History;Monitor;Mothers;National Institute of Child Health and Human Development;Nulliparity;nutrition;Observational Study;Ohio;Online Systems;Outcome Study;Participant;Pennsylvania;Perinatology;Placenta;Plasma;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prospective;Psychosocial Assessment and Care;Psychosocial Factor;Recording of previous events;repository;Research;Risk;Sampling;Services;Shipping;Specimen;System;Temperature;Tube;ultrasound;United States;Universities;Update;Urine;Utah;Uterus;Woman;Women's study

PROJECT_TITLE: STORAGE OF NUMOM2B SPECIMENS FOR THE PREGNANCY AND PERINATOLOGY BRANCH OF NICHD


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: SANDLER, DALE  (contact)

PROJECT_TERMS: abstracting;Anniversary;Area;Biological;Blood;Chronic Disease;Collection;Complement;computerized data processing;Contractor;Contracts;Data;Data Analyses;data management;Data Security;detection limit;Development;Equipment;experience;Funding;Funding Agency;Government;Government Agencies;Human;Human Resources;Medical Records;Methods;Participant;Pathologic;Phase;Physicians;Preparation;Qualifying;Quality Control;Questionnaires;Recommendation;Recurrence;Research;Sampling;Services;Sister;Statistical Data Interpretation;stool sample;Update;Urine;Validation;Work

PROJECT_TITLE: Sister Study TASK ORDER 02: CHRONIC DISEASE VALIDATION & ANALYSES IN THE SISTER STUDY


ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PI_NAMEs: BURNIN, DEBRA  (contact)

PROJECT_TERMS: absorption;Acute;analytical method;Animals;authority;Binding Proteins;Biological;Biological Assay;Biological Availability;Biological Products;Biological Testing;Blood;Canis familiaris;Cervical;Chemicals;Chronic;Clinical;clinical lot;Clinical Trials;Contraceptive Agents;Contraceptive Devices;Contraceptive methods;Contractor;Contracts;Country;cytotoxicity;Data;data sharing;design;Development;Device or Instrument Development;Devices;Documentation;Drug Exposure;Drug Formulations;Drug Kinetics;Drug Stability;drug testing;egg;Endocrine;Evaluation;Excretory function;Female Contraceptive Agents;Fertility;Formulation;Generations;Genetic;good laboratory practice;Good Manufacturing Process;Implant;In Vitro;in vivo;in vivo Model;Injectable;Intramuscular;Intravenous;Investigational Drugs;lot production;Male Contraceptive Agents;manufacture;Measures;Medical Device;men;Metabolism;Microsomes;Mission;Mus;National Institute of Child Health and Human Development;nonhuman primate;novel;novel therapeutics;Oogenesis;Oral;Oryctolagus cuniculus;Ovary;Ovulation;penis;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;Phase;Placebos;Plasma;Plasma Proteins;Play;pre-clinical;preclinical development;preclinical study;Preparation;Prevention;Process;product development;Program Development;Progress Reports;Property;Protocols documentation;Rattus;Reporting;reproductive;reproductive organ;Research;research clinical testing;Research Support;Role;Route;Safety;Seminal fluid;Services;Sheep;sperm cell;sperm function;Sperm Maturation;Spermatogenesis;subcutaneous;System;Teleconferences;Testing;timeline;Tissues;Toxic effect;Toxicokinetics;Toxicology;United States Food and Drug Administration;Uterus;Vagina;vaginal fluid;vaginal microbiome;Woman;Work

PROJECT_TITLE: BIOLOGICAL TESTING FACILITY (BTF) - PRECLINICAL DEVELOPMENT OF CONTRACEPTIVE PRODUCTS


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Precision Medicine;Radiation Oncology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: CORE 2: TRANSLATIONAL BIOSPECIMEN AND IMAGING BIOMARKER - NARRATIVE The Translational Biospecimen and Imaging Biomarker Core Component (Core 2) is building a unique centralized resource to support biospecimen and imaging data collection from radiation-treated patients, will support sample processing and sharing using standardized protocols. Such activities will be carried out for patients enrolled on the NIH-funded clinical trials as well as from other clinical studies of radiotherapy relevant to the hypotheses tested in this grant. Core 2 will establish a database repository with the goals of: (i) creating a standardized patient consent and enrollment process to create efficiencies of scale; (ii) streamlining logistics and processes, reducing redundancy and maximizing the use of human and laboratory resources; (iii) diminishing data loss due to inconsistencies between protocols; and (iv) creating a central resource for translational research and molecular studies at the MD Anderson and MGH Cancer Centers.

PI_NAMEs: SHAITELMAN, SIMONA  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Algorithms;analysis pipeline;automated segmentation;Basic Science;Biological;Biological Markers;Biopsy Specimen;Blood;Brain;cancer care;Cancer Center;Cancer Patient;Cardiology;Cardiopulmonary;Catalogs;cell culture collection;Cell Line;Central Nervous System;Characteristics;circulating biomarkers;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Trials;clinically relevant;Collection;Consent;Data;Data Collection;data de-identification;data exchange;Data Set;Databases;Dedications;Development;digital twin;Dose;Enrollment;experience;Functional Imaging;Funding;General Hospitals;Goals;Grant;Hepatic;Human;human tissue;Image;Image Analysis;imaging biomarker;imaging modality;Immune system;Immunologics;Immunophenotyping;Immunosuppression;improved;In Vitro;in vivo;individualized medicine;Informed Consent;innovation;Institution;interest;Laboratories;liver imaging;Logistics;Lung;Lymphocyte;Magnetic Resonance Imaging;Massachusetts;Medical;Mission;Molecular;Normal tissue morphology;novel;Oncology;participant enrollment;particle therapy;patient derived xenograft model;patient population;Patient-Focused Outcomes;Patients;personalized medicine;Photons;Physicians;pre-clinical research;precision medicine;Procedures;Process;Program Research Project Grants;prospective;Protein Analysis;Protocols documentation;proton therapy;Protons;Provider;Publications;Radiation;radiation adverse effect;Radiation Oncologist;Radiation therapy;Recommendation;repository;Research;Research Personnel;Resources;sample collection;Sampling;Scientist;Secure;Site;Specimen;Standardization;Technical Expertise;Testing;tissue culture;Tissues;Toxic effect;Translational Research;Treatment-related toxicity;Tumor Biology;Tumor Subtype;United States National Institutes of Health;Universities;University of Texas M D Anderson Cancer Center

PROJECT_TITLE: Core 2: Translational Biospecimens and Imaging Biomarkers


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Machine Learning and Artificial Intelligence;Radiation Oncology;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PI_NAMEs: DEASY, JOSEPH O (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Anatomy;anti-cancer research;Bioinformatics;Biological;Biology;Blood;Characteristics;Clinical Data;Collaborations;Data;Data Commons;data ecosystem;data exchange;data quality;Data Set;data sharing;Diagnostic;digital data;Digital Imaging and Communications in Medicine;digital twin;Dose;Ensure;Factor Analysis;Goals;Human;Image;Immune;Immunologic Markers;Infrastructure;innovation;insight;Learning;Link;Machine Learning;Magnetic Resonance Imaging;Maps;Methods;microbiome;Mission;Modeling;Molecular;Molecular Profiling;multimodality;Multivariate Analysis;novel;Operative Surgical Procedures;Patients;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Privatization;Publications;Radiation;Radiation therapy;radiomics;Reaction Time;Rectal Cancer;Research;Resources;Specimen;tool;Training;transcriptomics;treatment planning;tumor;X-Ray Computed Tomography

PROJECT_TITLE: Data Sharing and Integrative Analysis Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PI_NAMEs: MICHOR, FRANZISKA  (contact)

PROJECT_TERMS: access restrictions;Address;Age;analysis pipeline;Anatomy;Artificial Intelligence;Biological;Biological Assay;Blood flow;cancer genomics;Cells;Childhood;Clinical;clinically significant;Clonal Evolution;Collaborations;Communities;Complex;Computer Models;Computing Methodologies;Data;Data Collection;data exchange;data hub;data integrity;data management;data repository;Data Science;Data Science Core;Data Security;Data Set;Data Storage and Retrieval;Databases;design;diffuse midline glioma;digital twin;DNA Repair;Dose;dosimetry;Ensure;Epigenetic Process;Evolution;exome;experience;Face;Funding;genomic data;Genomics;Goals;Grant;Image;Immunofluorescence Immunologic;improved;individual patient;Infrastructure;interest;Link;Malignant Neoplasms;member;metaiodobenzylguanidine;Methodology;Methods;miRNA expression profiling;Modeling;Molecular;Natural Language Processing;neoplastic cell;Neuroblastoma;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;novel;Outcome;Patients;Pediatric Neoplasm;Peripheral Blood Involvement;Population;profiles in patients;Publishing;radiation effect;Radiation Oncology;radiation resistance;radiation response;Radiation therapy;radiomics;Radionuclide therapy;repository;Research Personnel;Resistance;Resource Sharing;Resources;single cell ATAC-seq;single-cell RNA sequencing;Specimen;Structure;structured data;System;The Cancer Genome Atlas;Training;transcriptome sequencing;transcriptomics;treatment planning;tumor;tumor heterogeneity;tumor microenvironment;Tumor Tissue;Weight;whole genome;Work

PROJECT_TITLE: Shared Resource Core 1: Molecular Data Science and Advanced Dosimetry


ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PI_NAMEs: ESCALERA, LIYA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TITLE: Research Education Core


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Invasive fungal infections are a major cause of complications and death in people living with weakened immune systems, and there are limited treatment options and emergence of resistance to available antifungal drugs. A well-vetted target for antimicrobial drugs is the ribosome, and though the fundamental core of the ribosome is conserved between humans and fungi, we have identified unique proteins that associate with the ribosome under stresses encountered by a particular fungal pathogen, Cryptococcus neoformans, when it enters the host. This proposal will explore these novel ribosome-associated factors for roles in stress adaptation, pathogenesis, and translation regulation, and will identify those with development potential for targeting the ribosome with specificity in fungal pathogens.

PI_NAMEs: PANEPINTO, JOHN C (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 5' Untranslated Regions;Affect;anti-fungal agents;anti-microbial drug;Antifungal Therapy;antimicrobial;Basidiomycota;Binding;biological adaptation to stress;Biology;Catalytic Domain;Cellular Stress;Cessation of life;comorbidity;Complex;Cryptococcus;Cryptococcus neoformans;Data;Defect;Development;Drug Targeting;Eukaryota;Exhibits;experimental study;Fungal Drug Resistance;fungus;Future;Goals;Growth;Heterogeneity;Homologous Gene;Human;human pathogen;Hypoxia;Immune system;immunodeficiency;Impairment;In Vitro;Intervention;Investigation;knock-down;Lung;Maps;Messenger RNA;Molecular Chaperones;mortality;mRNA capping;mRNA Decay;mutant;Mycoses;Names;novel;Oxidative Stress;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Patients;Peptide Initiation Factors;Persons;Pharmacologic Substance;Phenotype;Phosphorylation;Process;Prokaryotic Cells;Protein Biosynthesis;Protein Isoforms;Proteins;Proteomics;recruit;Regulon;Resistance;Ribosomes;RNA;RNA Recognition Motif;RNA-Binding Proteins;RNA-Protein Interaction;Role;scaffold;Sedimentation process;Signal Pathway;Specificity;Stress;stress tolerance;Structure;Techniques;Temperature;Testing;Therapeutic;Translating;translation factor;Translation Initiation;Translational Regulation;Translations;translatome;Transplantation;Virulence;Work

PROJECT_TITLE: Ribosome Heterogeneity in Cryptococcus neoformans


NIH_SPENDING_CATS: Cancer

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PI_NAMEs: KUSHI, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Disability Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: REIS, STEVEN E (contact);VISWESWARAN, SHYAM

PROGRAM_OFFICER_NAME: MCNEIL FORD, NICOLE

PROJECT_TERMS: Acceleration;Address;Adult;All of Us Research Program;Area;Biomedical Research;Black church;Black Populations;Black race;career;Caring;Child;Cities;Clinical Management;Clinical Sciences;cohort;Communication;Communities;community advisory board;community engaged research;community engagement;Community Health;community organizations;community partnership;Community Pharmacy;community research;Community Services;County;Data;Data Analytics;data exchange;Dedications;design;disability;Disabled Persons;Empathy;empowerment;Enrollment;Environment;Epidemic;Equity;ethnic diversity;ethnic minority;Evaluation;Event;experience;Faith;Fostering;Friends;Goals;health care availability;health care delivery;Health Personnel;Healthcare;Helping to End Addiction Long-term;Hispanic;hispanic community;Hospitals;Human;human centered design;Human Engineering;Immigrant;improved;Independent Living;Individual;Informatics;Infrastructure;Institutional Review Boards;interest;Laboratory Research;Latino;Leadership;Learning;Lived experience;Location;Maps;marginalized population;Marketing;Media Campaign;meetings;member;Methods;Minority;Mission;Modeling;Multimedia;neighborhood disadvantage;Neighborhoods;operation;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid use disorder;Outpatients;outreach;Parents;Participant;participant enrollment;participant retention;patient engagement;Pennsylvania;Pharmacists;Pharmacy facility;Philadelphia;physically handicapped;Population;Process;programs;Protocols documentation;prototype;Public Health;racial diversity;racial minority;Ramp;Registries;Research;research and development;Research Ethics;Research Support;Research Training;Resources;Rural;rural area;Rural Community;Self-Help Devices;service organization;Services;Site;skills;Speed;Spinal;stimulant use disorder;success;Time;Training;Training Activity;Translational Research;trustworthiness;United States;United States National Institutes of Health;Universities;virtual;Work

PROJECT_TITLE: All of Us Pennsylvania (AOU PA) Research Program


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative: The FDA Vet-LIRN Veterinary Diagnostic Laboratory Program enables, nationwide, the analyses of animal diagnostic samples and animal food/drug products. The Program fills a gap for the FDA Office of Regulatory Affairs (ORA) regarding veterinary diagnostic samples that greatly facilitates early detection of and response to animal food/drug adulteration and contamination events. Through the Vet- LIRN program, FDA leverages the expertise of a national system of university, state and federal veterinary diagnostic laboratories to provide additional capacity and capability, obtain veterinary diagnostic information critical to ORA response, and strengthen the overall national food safety system.

PI_NAMEs: SNEKVIK, KEVIN ROY (contact)

PROGRAM_OFFICER_NAME: CERIC, OLGICA

PROJECT_TITLE: FDA Veterinary Laboratory Investigation and Response Network Cooperative Agreement Program-WA


NIH_SPENDING_CATS: Cancer;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: This study will support the national goals of the AOURP study, which aims to build and maintain the largest US-based population cohort, complete with EHR records and genomics. Our specific contributions will focus on enrollment participants as part of the HEAL study engaging individuals that suffer from opioid user disorder. We will further keep engaging our existing cohort of nearly 20,000 AOURP participants and continue to educate them on the benefit and changes of AOURP.

PI_NAMEs: MCCAULEY, JACOB L;ZUCHNER, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: RAHMAN, MD MIZANUR

PROJECT_TERMS: Academic Medical Centers;Address;Adoption;Advanced Malignant Neoplasm;Age;Agriculture;All of Us Research Program;Ally;Artificial Intelligence;Asian;Attention;Authorization documentation;Awareness;Baptist Church;big-data science;biobank;Biomedical Research;Black American;Black race;Calendar;cancer genetics;cancer therapy;catalyst;Categories;Child;Child health care;Childhood;Climate;Clinic;cohort;Collaborations;Collection;Communication;Communities;Community Networks;community organizations;community partners;community-centered;Comprehensive Cancer Center;Computers;Consent;Contracts;County;dashboard;Data;Data Set;data streams;Development;Devices;digital;digital measure;disability;Education;Education and Outreach;Elements;Enrollment;Ensure;Environment;Epidemic;Equipment and supply inventories;Equity;ethnic minority population;Ethnic Origin;Evaluation;experience;Eye diseases;Face;Faculty;Family;Feedback;Florida;follow-up;Food;Fostering;Foundations;Funding;Future;Gastrointestinal Diseases;gene therapy;Genetic;Genetic study;Geographic Locations;Geography;Goals;Greek;Health;health data;Health Personnel;Health Status;Height;Helping to End Addiction Long-term;Hispanic;Historically Black Colleges and Universities;Home;Hospitals;human old age (65+);Human Resources;improved;Independent Living;Individual;information gathering;Informed Consent;Infrastructure;innovation;insight;Institution;interest;Internet;Island;Joints;Language;Lead;Learning;Letters;Libraries;life span;Location;Maintenance;Marketing;Measurement;Measures;Medical;Medical center;Medical Records;Medical Research;Methodology;Modeling;Morehouse School of Medicine;novel;Nurses;Opiate Addiction;Opioid;opioid epidemic;opioid misuse;opioid overdose;opioid use disorder;outreach;outreach program;Participant;participant enrollment;participant retention;patient engagement;patient registry;Patients;Pediatric Hospitals;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Population;population health;Population Heterogeneity;Private Hospitals;Procedures;Process;programs;Progress Reports;Protocols documentation;Public Health;Public Hospitals;Puerto Rico;Race;racial minority population;Rare Diseases;Recording of previous events;Records;recruit;Regulation;Research;Research Personnel;research study;Research Support;Resources;retention rate;Role;Rotation;Rural;rural area;Saliva;Science;segregation;Self Direction;Site;Slide;social media;Speed;stimulant use disorder;success;Surveys;symposium;synergism;System;telehealth;Telephone;Testing;tool;Touch sensation;Training;Transportation;Travel;Trust;trustworthiness;United States;United States National Institutes of Health;United States National Library of Medicine;Universities;Update;Vision;volunteer;Weight;Work

PROJECT_TITLE: Southeast Enrollment Center Consortium 2 (SEEC-2)


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: North Bethesda

ORG_NAME: FOUNDATION FOR THE NIH

PI_NAMEs: ADAM, STACEY  (contact)

PROGRAM_OFFICER_NAME: SHEELEY, DOUGLAS

PROJECT_TERMS: Acceleration;Address;Architecture;cloud based;complex data;Computer Security;Contractor;cost;Data;data access;Data Analyses;Data Collection;data exchange;data infrastructure;data ingestion;data modeling;data standards;design;Developed Countries;Development;Electronic Health Record;empowerment;experience;Foundations;Future;Goals;Health;health data;Health Sciences;Healthcare Systems;improved;Industry;interoperability;meetings;Modeling;Modernization;novel;novel strategies;Outcome;patient engagement;Patients;Performance;Phase;Process;programs;public-private partnership;Research Personnel;Risk;Science;Secure;Security;Speed;Strategic Planning;System;Time;transmission process;Treatment Factor;Treatment outcome;Trust;United States;United States National Institutes of Health

PROJECT_TITLE: Creation of a Trusted Data Broker, Development of a Data Access Platform and Design of a Public Private Partnership to Implement the NIH's Data COUNTS Program for Access to Quality Data.


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PI_NAMEs: JONES, RICHARD J (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TITLE: Targeting Cancer Stem Cells


PI_NAMEs: LUZNIK, LEO  (contact)

PROJECT_TITLE: Marrow-Infiltrating Lymphocytes


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS

PI_NAMEs: BOLLARD, CATHERINE M. (contact)

PROJECT_TITLE: Antigen Specific T Cells


PI_NAMEs: COOKE, KENNETH R (contact)

PROJECT_TITLE: BMT in Solid Tumors


PROJECT_TITLE: Administrative Core


PI_NAMEs: VARADHAN, RAVI  (contact)

PROJECT_TITLE: Biostatistics Core


PROJECT_TITLE: Immune Monitoring Core


PI_NAMEs: LEMAS, VICTOR M (contact)

PROJECT_TITLE: Cell Therapy Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAINT CHARLES

ORG_NAME: EUROFINS PANLABS, INC.

ORG_STATE: MO

PI_NAMEs: BODE, JACOB  (contact)

PROJECT_TERMS: Antibiotic Resistance;Antimicrobial Resistance;Biological;Chemistry;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Development;Development Plans;Drug Design;Drug Kinetics;Evaluation;In Vitro;in vivo;Interventional Agent Development;Lead;manufacture;pathogen;pre-clinical;product development;programs;Safety;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task B31: Bulk Intermediate Scaleup for Antibiotic-Resistant Drug Design


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Precision Medicine;Social Determinants of Health;Substance Misuse

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The AoURP at Mount Sinai contributes data from participants to a dataset that researchers could use to advance precision medicine, study diseases, and determine effective treatments. In the long term, data and insights from the AoURP may be used to determine new approaches for preventing disease.

PI_NAMEs: HOROWITZ, CAROL R;KRAFT, MONICA  (contact);NADKARNI, GIRISH NITIN;SHROFF, NANDINI ;SHUMAN, SASKIA

PROGRAM_OFFICER_NAME: LOPEZ-CLASS, MARIA

PROJECT_TERMS: Academic Medical Centers;Adult;Advocate;All of Us Research Program;Area;Arizona;Asian population;biobank;Biomedical Research;Child;Childhood;Cities;Clinical;clinical infrastructure;Clinical Trials Network;Collaborations;Communities;community collaboration;community consultation;community engagement;Community Health Aides;Community Networks;community organizations;Country;COVID-19;dashboard;Data Set;data tools;Databases;Enrollment;Ensure;Equity;ethnic minority population;experience;Family health status;Federally Qualified Health Center;Funding;Genomics;Geography;Goals;Grant;Health;health care delivery;Health equity research;Health system;Healthcare;Helping to End Addiction Long-term;Hospitals;improved;Infrastructure;Inpatients;insight;Institution;interest;Lead;Learning;Link;Marketing;Medicine;meetings;metropolitan;Municipalities;Neighborhoods;New York;New York City;non-genomic;Opiate Addiction;Opioid;opioid misuse;Outpatients;outreach;Participant;Patient Recruitments;Patient-Focused Outcomes;Patients;Population Heterogeneity;programs;Provider;Public Health;Qualifying;racial minority population;Recording of previous events;Recovery;recruit;Research;Research Institute;Research Personnel;Researching COVID to Enhance Recovery;retention rate;Services;Site;Speed;success;System;Training Programs;Trust;Underrepresented Populations;United States;United States Health Resources and Services Administration;United States National Institutes of Health;Universities

PROJECT_TITLE: All of Us Research Program New York Consortium


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: LAGOS

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: NIGERIAN INSTITUTE OF MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Persistent low-level viremia (LLV) in persons with HIV who are on antiretroviral therapy (ART) is a barrier to achieving the goal of zero transmission and eradication of HIV, but not much is known about the impact of LLV on attaining the ART goal of viral suppression in West Africa. The proposed research will use pharmacoepidemiologic methods to assess the prevalence of LLV and impact on ART outcomes. The study will also use mathematical modeling to predict future LLV with adherence to ART measured by innovative pharmacological techniques.

PI_NAMEs: HERBERTSON, EBIERE CLARA (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;adolescent health;Adult;advanced analytics;Africa;Africa South of the Sahara;African;Anti-Retroviral Agents;Anti-retroviral drug resistance;antiretroviral therapy;Appointment;Award;biological sex;Blood;career;career development;Caring;Cells;Cessation of life;Chronic;Clinical;clinical care;Clinical Pharmacology;clinical prognosis;cohort;Collection;Communicable Diseases;comorbidity;comparative;Country;Data;Data Analyses;Databases;Development Plans;Diphosphates;Drug Exposure;Drug resistance;Dryness;Epidemic;Epidemiologist;Epidemiology;Event;evidence base;experience;Failure;follow-up;Funding;Future;Goals;Guidelines;Hair;HIV;HIV-1;HIV-2;improved;Individual;innovation;insight;Intake;International;Intervention;K-Series Research Career Programs;Knowledge;Learning;Literature;longitudinal, prospective study;mathematical model;Measurement;Measures;Mentors;Methods;Monitor;Names;Nigeria;Outcome;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Pharmacology;Pharmacy facility;pill;point of care;point of care testing;Policies;Policy Maker;population health;Predictive Value;Prevalence;prognostic value;Prospective cohort;Public Health;Records;Regimen;Reproductive Health;Research;Research Design;Research Personnel;Resistance;Resistance development;Resource-limited setting;Retrospective cohort;scale up;Scientist;Site;skills;socioeconomics;Source;Specialist;Spottings;statistics;study population;Techniques;Tenofovir;Testing;therapy outcome;Training;translational physician;translational scientist;transmission process;treatment guidelines;Treatment outcome;Urine;Viral;Viral load measurement;Viral Load result;Viral reservoir;Viremia;Virus Activation;Women's Health

PROJECT_TITLE: Use of Pharmacoepidemiology to Understand Predictors and Impact of Low-level Viremia in Persons with HIV in West Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-J(55)R]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Osteoporosis is a prevalent disease characterized by low bone mineral density, bone fragility, and fractures. Mice lacking the potassium ion channel Girk3 have elevated bone mass and reduced circulating cytokines in adulthood, making Girk3 a novel target for bone remodeling. This research will determine the physiological and cellular mechanisms by which Girk3 regulates cytokine production and bone mass and test whether Girk3 deletion prevents ovariectomy-induced osteoporosis in a cytokine-dependent manner.

PI_NAMEs: WEAVER, SAMANTHA R (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adult;Affect;Age;aged;aging process;Applied Skills;Award;Bioinformatics;Biological Assay;Biological Markers;Biology;Blood;bone;bone cell;Bone Density;Bone Development;Bone Diseases;bone fragility;bone loss;Bone Marrow;Bone Marrow Cells;bone mass;Bone remodeling;Bone Resorption;Calvaria;career;career development;Cell Lineage;Cells;Cellularity;Clinic;Continuous Infusion;cytokine;Cytometry;Data;Development;Development Plans;Disease;Educational workshop;Endocrinology;Enzyme-Linked Immunosorbent Assay;experimental study;Female;Foundations;Fracture;Goals;GTP-Binding Proteins;Harvest;Hematopoietic;IL3 Gene;improved;In Vitro;Inflammation Process;Inflammatory;innovation;Interleukin-1;Interleukin-1 beta;inward rectifier potassium channel;Ion Channel;Ion Channel Gating;Ions;Knowledge;Laboratories;Lead;Learning;Macrophage;male;Measures;Mechanics;meetings;Membrane;men;Mentors;Mentorship;Messenger RNA;Methods;microCT;Modeling;Molecular;monocyte;mouse model;Mus;Musculoskeletal;novel;old mice;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Ovariectomy;Phase;Physiological;Physiological Processes;Population;Positioning Attribute;Postdoctoral Fellow;Postmenopausal Osteoporosis;Potassium;Potassium Channel;pre-doctoral;prevent;Production;programs;Publications;Publishing;Research;research and development;Research Personnel;Role;Safety;Serum;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skeletal;Skeleton;skills;success;symposium;synergism;Testing;Time;tool;Training;transcriptome;transcriptomics;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Girk3 in bone biology and disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Nutrition;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: VILAR SANCHEZ, EDUARDO  (contact)

PROJECT_TERMS: Biological Markers;biomarker identification;cancer prevention;Development;Diet;efficacy evaluation;Fasting;Goals;immune cell infiltrate;Intervention;Malignant neoplasm of pancreas;microbiome composition;mouse model;Mus;pancreatic cancer model;Pancreatic Intraepithelial Neoplasia;Prevention;Regimen;Time-restricted feeding;Treatment Efficacy;tumor growth

PROJECT_TITLE: TIME-RESTRICTED FEEDING FOR PANCREATIC CANCER PREVENTION


NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PI_NAMEs: ANDERSON, ALEXANDER ROBERTSON ALLAN (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adherence;Award;Budgets;Cancer Center;Collaborations;Communication;dashboard;Development;Ecology;Education;Education and Outreach;Educational workshop;Ensure;equity, diversity, and inclusion;Evaluation;Fostering;Funding;Funding Opportunities;high school;Information Distribution;innovation;Institution;interest;Internships;Investigation;Letters;Malignant Neoplasms;meetings;member;Mission;Non-Small-Cell Lung Carcinoma;Organization and Administration;outreach;Pilot Projects;Play;Preparation;Process;programs;Progress Reports;Reporting;Research;Research Personnel;Resources;Role;social media;symposium;Systems Biology;Travel;web site


ORG_NAME: ROCKEFELLER UNIVERSITY

PI_NAMEs: MUCIDA, DANIEL S (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TITLE: Project-2:Defining the role of compartmentalized neuro-lymphatic networks on CRC and metastatic progression


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: MAMMEN, ANDREW  (contact)

PROJECT_TERMS: Adolescent;Adult;Antibodies;Autoantibodies;Autoantigens;Autoimmune;Biopsy;Cell Nucleus;Clinical;cohort;Dermatomyositis;Diagnosis;Disease;Family;Gene Expression;Goals;Idiopathic Inflammatory Myopathies;Immune;Immunogenetics;improved;Inclusion Body Myositis;Laboratories;Ligase;Mediating;Messenger RNA;MicroRNAs;multi-ethnic;Muscle;Muscle Cells;Myopathy;Myositis;novel;Pathogenesis;Patient Care;Patients;Phenotype;Proteins;Publishing;Raynaud Disease;Risk Factors;Syndrome;therapeutic target;transcriptional intermediary factor 1;transcriptomics

PROJECT_TITLE: Muscle Disease Unit


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: SHEEHAN, FRANCES T (contact)

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Adolescent;Adult;Agreement;Anatomy;Animals;Ankle;anterior cruciate ligament injury;Architecture;Area;Athletic Injuries;automated segmentation;Award;Biological Markers;bone;Cadaver;Cartilage;Categories;Cerebral Palsy;Child;Clinical;Clinical Data;clinical diagnosis;clinical diagnostics;Clinical Treatment;cohort;Collaborations;Computer Models;Connective Tissue;Data;Data Analyses;Databases;design;Development;Diagnosis;Diagnostic;Diagnostic radiologic examination;diagnostic tool;digital imaging;disability;Discipline;Disease;Dislocations;Dystonia;Ehlers-Danlos Syndrome;Engineering;Evaluation;experimental study;Femur;France;functional loss;functional restoration;Future;Goals;hamstring;Image;Impairment;improved;in vivo;Individual;Injury;International;Intervention;joint function;Joints;Journals;kinematics;Kinetics;Knee;Knowledge;Ligaments;Magnetic Resonance Imaging;Manuscripts;Matched Group;Measurement;Measures;Medical;Methodology;Methods;millimeter;Modeling;motor impairment;Movement;Muscle;muscle degeneration;Muscular Dystrophies;Musculoskeletal;musculoskeletal injury;Musculoskeletal System;National Human Genome Research Institute;Natural History;Neurodegenerative Disorders;Neurologic;neuromuscular;neuromusculoskeletal;Pain;Paper;Patellar Dislocation;Pathology;Patients;Pattern;physically handicapped;Population;Positioning Attribute;Preparation;Process;Property;Protocols documentation;Publishing;Recording of previous events;Recovery of Function;Recurrence;Research;Research Personnel;Resolution;Role;segmentation algorithm;Shapes;Shoulder;skeletal;soft tissue;Spinal;Stress;Structure;Surface;Syndrome;System;Tendon structure;three-dimensional visualization;Tissues;tool;two-dimensional;ultrasound;United States National Institutes of Health;Validation;virtual;Work;Wrist

PROJECT_TITLE: Virtual Functional Anatomy


PROJECT_TITLE: Vasti Control of Patellofemoral Kinematics in Asymptomatic Volunteers


PROJECT_TERMS: 3-Dimensional;Address;Analysis of Variance;Anterior;Bupivacaine;Chronic;Complex;Confounding Factors (Epidemiology);Data;Data Collection;Degenerative polyarthritis;Enrollment;Equilibrium;Event;Exercise;Extensor;Freedom;Goals;Iatrogenesis;Individual;Injections;Isometric Exercise;Joints;kinematics;Knee;Knee bone;Knee joint;knee pain;Kolmogorov-Smirnov Test;Lateral;Lead;Leg;Lidocaine;Linear Regressions;Link;Local Anesthetics;loss of function;Magnetic Resonance Imaging;Measurement;Measures;Medial;Modeling;Motion;Movement;Muscle;Nerve Block;Normalcy;Operative Surgical Procedures;Pain;pain reduction;pain relief;Patellofemoral Pain Syndrome;Patients;Peripheral Nerves;Phase;Protocols documentation;quadriceps muscle;Recording of previous events;Rotation;Running;skeletal;Source;statistics;Stress;Structure;Techniques;Testing;theories;tool;Translations;Trauma;vastus lateralis;vastus medialis;Visit;volunteer;Work

PROJECT_TITLE: Vasti Control of Patellofemoral Kinematics in Patients with chronic Patellofemoral pain


PROJECT_TERMS: Address;Adolescent;Affect;Agreement;Architecture;arm;arthropathies;automated segmentation;Biomechanics;Career Choice;Childhood;computerized data processing;Data;data sharing;Databases;deep learning model;Development;Dimensions;Disease;education pathway;effective intervention;Human;Image;in vivo;Individual;Intervention;joint destruction;Knee bone;knee pain;Lateral;Manuscripts;Measures;Mental Health;Modeling;Muscle;Musculoskeletal;Musculoskeletal Pain;Musculoskeletal System;Nervous System control;Pain;Paper;Patellofemoral Pain Syndrome;Pathology;Physiology;Population;prevent;quadriceps muscle;Queensland;rectus femoris;Recurrent pain;Reporting;Research;Resolution;Rest;Role;Social Interaction;Sports;Techniques;tool;Torque;Universities;vastus lateralis;vastus medialis;Work

PROJECT_TITLE: Balancing Muscle Force in Patellofemoral Pain


PI_NAMEs: ZELAZNY, ADRIAN MARCELO (contact)

PROJECT_TERMS: accurate diagnostics;Antimicrobial Resistance;Award;Bacteria;Biochemical;Biological Assay;cell free DNA;Clinical;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Databases;Detection;detection assay;detection method;Development;Diagnostic;fungus;genome sequencing;Genomics;Genus Mycobacterium;Goals;Hydrolysis;improved;Laboratories;Lung;lung injury;Mass Spectrum Analysis;Methodology;Methods;Microbe;microbial;Microbiology;microorganism;Microscopy;Molds;Molecular;Morphology;mycobacterial;novel;Organism;Pathogen detection;Peptides;Phenotype;point of care;Process;Property;Proteins;Proteomics;respiratory;Sampling;Serum;targeted sequencing;Techniques;Testing;United States National Institutes of Health;whole genome;Yeasts

PROJECT_TITLE: Identification of Clinically Important Microbes by Genomic and Proteomic Methods


PROJECT_TERMS: Address;Affect;Amikacin;anti-microbial drug;antimicrobial;Antimicrobial Resistance;Bacteria;beta-Lactam Resistance;Cell Communication;chemotherapy;chronic infection;Clarithromycin;Clinical Data;Development;Disease Outbreaks;drug repurposing;Epidemiology;epidemiology study;Evolution;fungus;Genes;Goals;indexing;Individual;individual patient;Investigation;Laboratories;Microbe;microbial;Microbiology;microorganism;Molecular;Multi-Drug Resistance;Mycobacterium abscessus;Nitric Oxide;novel;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic microbe;Pathogenicity;patient population;Patients;Pharmacotherapy;Phenotype;Population;Process;Reporting;Resistance;Respiratory Tract Infections;synthetic peptide;trait;Virulence

PROJECT_TITLE: Molecular and Virulence Traits of Bacteria & Fungi Causing Persistent Infections


PI_NAMEs: CALVO, KATHERINE  (contact)

PROJECT_TERMS: Abnormal megakaryocyte;Age;Algorithms;Aplastic Anemia;Apoptosis;Autoimmune;autoinflammatory;autosome;Benign;Binding;Biological Assay;Biology;Blood Platelets;Bone Marrow;Bone Marrow Cells;Bone Marrow Diseases;Bone marrow failure;cancer predisposition;candidate selection;Cell Line;Cell Physiology;Clinical;Clonal Evolution;Core Biopsy;CTLA4 gene;Custom;Cytogenetics;cytokine;cytopenia;Data;Data Analyses;Data Correlations;Development;Diagnosis;diagnostic accuracy;diagnostic criteria;differential expression;digital;Disease;Disease Progression;Dysmorphology;Dysmyelopoietic Syndromes;Dysplasia;Dysplastic Megakaryocyte;Ensure;Erythroid;Evaluation;Failure;Familial Platelet Disorder;Flow Cytometry;GATA2 deficiency;Gene Expression Profile;Genes;Genetic;Genome Mappings;Genotype;Germ Lines;Germ-Line Mutation;Goals;Hematologic Neoplasms;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic Neoplasms;Immunophenotyping;Impairment;Individual;Inherited;insight;ITGB3 gene;lifetime risk;Malignant Neoplasms;Marrow;meetings;Megakaryocytes;Messenger RNA;Methylation;MicroRNAs;Molecular;Monoclonal gammopathy of uncertain significance;Morphology;Mutation;Mutation Analysis;Myelogenous;Myeloid Cells;Myeloproliferative disease;Neoplasms;Neoplastic Processes;next generation sequencing;novel;Optics;Outcome;Pathologic;Pathologist;Pathology;patient subsets;Patients;Pattern;peripheral blood;Phenotype;Plasma Cells;Population;Post-Transcriptional Regulation;Predisposition;Production;Proliferating;Publications;Regulation;RUNX1 gene;Somatic Mutation;Specimen;Syndrome;Technology;Time;Transcript;transcriptomics;Translational Repression;treatment response;tumorigenesis;validation studies;Work

PROJECT_TITLE: microRNA, immunophenotypic, and somatic alterations in hematologic malignancies


PI_NAMEs: DAS, SANCHITA  (contact)

PROJECT_TERMS: 2019-nCoV;Address;adenovirus penton protein;Adenoviruses;Affect;Algorithms;Allogenic;Amino Acids;Archives;Area;B-Lymphocytes;Bioinformatics;Biological Assay;Capsid;Capsid Proteins;chronic infection;Clinical;Code;cohort;Communicable Diseases;Complex;COVID-19 detection;COVID-19 pandemic;Defect;DNA;emerging virus;Environment;Epidemiology;Evolution;gastrointestinal;Genes;Genetic Drift;Genetic Recombination;Genetic Variation;Genotype;Goals;Hematological Disease;Hematopoietic Stem Cell Transplantation;Homologous Transplantation;Immunocompromised Host;immunosuppressed;Infection;insight;Journals;Length;Libraries;Life;Lymphocyte;metagenomic sequencing;Metagenomics;Methods;microbiome;mortality;Mutation;novel;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;patient population;Patients;Phylogenetic Analysis;Phylogeny;Plasma;Preparation;pressure;Publications;Reporting;Research;respiratory;SARS-CoV-2 infection;SARS-CoV-2 variant;Satellite Viruses;Shotgun Sequencing;Shotguns;Source;Specimen;T-Cell Depletion;Time;Transplant Recipients;Urinary system;Variant;variant detection;Viral;Viral Epidemiology;Viral Load result;Viremia;virome;Virus;Virus Activation;Virus Diseases;Virus Replication;Wit

PROJECT_TITLE: Understanding the Epidemiology of Adenovirus and its Evolution in Patients with Viremia


PI_NAMEs: SEYEDMOUSAVI, AMIR  (contact)

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affect;Animals;anti-fungal agents;Behavior;biological research;Biology;Chronic;Clinical Trials;comparative genomics;congenital immunodeficiency;Disease;Epidemiology;Evaluation;functional genomics;Fungal Drug Resistance;fungus;Genes;genome sequencing;Goals;Health;Hospitalization;Human;Hypersensitivity;Immunity;Immunocompetent;Immunocompromised Host;immunodeficiency;Individual;Infection;interest;Life;Location;Malignant Neoplasms;Medical;Molecular;Molecular Epidemiology;mouse model;Mycoses;Organ Transplantation;participant enrollment;pathogenic fungus;Pathogenicity;Patients;Pattern;Persons;Phylogenetic Analysis;pre-clinical research;Predisposition;Proteomics;Risk;screening;Taxonomy;Translational Research;Trauma;United States National Institutes of Health;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Comparative Genomics and Pathogenicity of Agents of Human and Animal Fungal Infections


PROJECT_TERMS: Acute Myelocytic Leukemia;Algorithms;Animals;anti-fungal agents;Antibodies;Antifungal Therapy;antigen test;antimicrobial;Area;Biological;Biological Markers;Clinical;Complex;Detection;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic technologies;diagnostic tool;Disease;Evolution;Fungal Drug Resistance;fungus;Genetic;genome-wide;Hospitalization;Human;Immunocompromised Host;improved;In Vitro;in vivo;Intensive Care Units;interest;Laboratories;Laboratory Research;Life;Molds;Molecular;mortality;Mycoses;next generation sequencing;novel;novel diagnostics;Nucleic Acid Amplification Tests;Operative Surgical Procedures;pathogenic fungus;Patients;pharmacokinetics and pharmacodynamics;point of care;Prevalence Study;Research;Sampling;Sensitivity and Specificity;Serology test;Specimen;Technology;Testing;The science of Mycology;Therapeutic;Trauma;United States National Institutes of Health;Yeasts

PROJECT_TITLE: Antifungal Resistance and Novel Mycology Diagnostics


PROJECT_TERMS: Achromobacter;Achromobacter xylosoxidans;Alcaligenes;American;anti-microbial drug;Anti-microbial susceptibility;Antimicrobial Resistance;Ceftazidime;Clinical;efflux pump;genome sequencing;genomic data;Genomics;Laboratories;Lactamase;Literature;Mediating;meetings;Methods;Microbe;Microbiology;Minimum Inhibitory Concentration measurement;Molecular;Nature;Organism;pathogen;patient population;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Resistance;resistance mechanism;Resistance profile;Rod;Societies;Testing;Time;trait;whole genome;Work

PROJECT_TITLE: Antimicrobial Susceptibility of Achromobacter spp. vs ASA spp


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: BEWLEY, CAROLE  (contact)

PROJECT_TERMS: Binding;Biological Assay;Chemistry;Data Analyses;Development;Educational process of instructing;Goals;Laboratories;Methodology;Mission;molecular dynamics;NMR Spectroscopy;Research;Research Personnel;Research Project Grants;Scientist;Services;Structure;Techniques;United States National Institutes of Health

PROJECT_TITLE: NMR Facility Management and Application of NMR Spectroscopy


ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: STAR, ROBERT A (contact)

PROJECT_TERMS: Ablation;Acute;Acute Kidney Failure;Acute Renal Failure with Renal Papillary Necrosis;Age;Anemia;Angiotensin II;Angiotensin Receptor;Animal Model;Animals;Antibiotics;Biological Markers;biomarker discovery;Blood Pressure;Body Temperature;CD36 gene;cecal ligation puncture;Chronic;Chronic Kidney Failure;clinically relevant;Collaborations;Combined Modality Therapy;comorbidity;Complex;Conscious;coronary fibrosis;Death Rate;Disease;disease model;Dissociation;Drug Screening;effective therapy;effectiveness testing;epidemiologic data;epidemiological model;Fibrosis;Functional disorder;glomerulosclerosis;Heart Rate;Hospitals;Hypertension;in vivo;Incidence;Injury;Injury to Kidney;interstitial;Kidney;Kidney Diseases;kidney dysfunction;Knock-out;Liquid substance;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Nephrectomy;Nephrology;non-invasive monitor;novel;novel therapeutic intervention;old mice;olmesartan;Operative Surgical Procedures;Organ;Outcome;Pathway interactions;patient subsets;Patients;Peritonitis;Phenotype;Predisposition;Procedures;Process;Proteinuria;Rattus;renal ischemia;Reperfusion Therapy;resistant strain;Sampling;Sepsis;Syndrome;systemic inflammatory response;Telemetry;Testing;Tubular formation;Work

PROJECT_TITLE: Inhibition Of Renal Injury


NIH_SPENDING_CATS: Cancer;Clinical Research;Rare Diseases

PI_NAMEs: NIEMAN, LYNNETTE  (contact)

PROJECT_TERMS: adenoma;Adrenal Gland Hyperfunction;Classification;Clinical Trials;Consensus;Corticotropin;Cushing Syndrome;Disease;Disease remission;Frequencies;GNRH1 gene;Gonadotropins;Hydrocortisone;Hypogonadism;Hypothalamic structure;improved;insight;Intervention;Logistic Regressions;Malignant Neoplasms;Measurement;Mediating;men;Neuroendocrine Tumors;Operative Surgical Procedures;Outcome Measure;Patients;Physiologic pulse;Physiology;Pituitary-dependent Cushing's disease;Plasma;Postoperative Period;reproductive axis;response;restoration;SHBG gene;symposium;Testosterone;Thyroid Hormones;Time;trend;tumor

PROJECT_TITLE: The Physiology Of Hypercortisolism


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Obesity;Pediatric

PI_NAMEs: CHUNG, STEPHANIE THERESE (contact)

PROJECT_TERMS: Abdomen;acceptability and feasibility;Address;Adult;Adverse effects;Age;Bacteria;Chronic;Clinical;clinical center;clinical practice;clinically significant;COVID-19 pandemic;Cross-Over Trials;Data;Data Analyses;design;Diabetes Mellitus;Diarrhea;Diet;Double-Blind Method;Eating;Enrollment;falls;FDA approved;Feces;Fiber;Food;gastrointestinal;gastrointestinal symptom;Glucose;Hormones;improved;Individual;Insulin;Intervention;Manuscripts;Marketing;medication compliance;Metformin;microbial;microbiome;microbiome therapeutics;Muscle Cramp;Nature;Non-Insulin-Dependent Diabetes Mellitus;Notification;Obesity;open label;Oral;Outpatients;Participant;Pharmaceutical Preparations;Phase;Pilot Projects;Placebos;Plasma;polyphenol;prebiotics;Procedures;Protocols documentation;Publishing;Randomized;recruit;Schedule;screening;side effect;Standardization;Testing;Time;trial planning;United States National Institutes of Health;Visit;Volatile Fatty Acids;young adult;Youth

PROJECT_TITLE: Prebiotics and Metformin Influences Gut and Hormones in Type 2 Diabetes Youth (MIGHTY-Fiber)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurosciences;Nutrition;Obesity;Prevention;Sleep Research

PROJECT_TERMS: actigraphy;Adult;adult obesity;aged;Biological;Biological Clocks;Body Temperature;circadian;cohort;Cross-Over Studies;Dietary Fats;Eating;Fatty acid glycerol esters;Glucose;Hour;Individual;Insulin;Light;Link;Melatonin;men;Metabolic;Nutritional;Obesity;Oral;Outcome;oxidation;Palmitates;Participant;Persons;Phase;Phenotype;Prediabetes syndrome;Protocols documentation;Randomized;recruit;Schedule;sex;Sleep;Time;United States National Institutes of Health;Universities;Visit;volunteer;Weight;Woman;Wrist

PROJECT_TITLE: Dinner Time for Obesity and Prediabetes (DTOP)


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity;Women's Health Research

PROJECT_TERMS: Antiinflammatory Effect;beta-Hydroxybutyrate;biological sex;Biology;cardiometabolism;CD4 Positive T Lymphocytes;Cells;Classification;clinical translation;design;Desire for food;dietary;Dietary Intervention;Enrollment;Fasting;gastrointestinal symptom;Guidelines;Hormonal;Immune;immunoregulation;in vivo;Individual;Inflammation;Inflammatory;Institutional Review Boards;interest;Intermittent fasting;Interruption;Isotopes;ketogenesis;Ketone Bodies;Ketones;Mediating;men;Metabolic;Metabolism;Obesity;Outcome;Participant;Pathway interactions;Phenotype;Pilot Projects;Process;Protocols documentation;recruit;Regimen;Research;response;Role;sex;Signal Transduction;stability testing;stable isotope;stress symptom;supply chain;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;Thinness;Time;Time-restricted feeding;translational study;United States National Institutes of Health;Woman;women versus men

PROJECT_TITLE: Pilot Study of Isocaloric Time Restricted Eating on Ketone Metabolism andImmunoregulation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rheumatoid Arthritis;Scleroderma

PI_NAMEs: KASTNER, DANIEL  (contact)

PROJECT_TERMS: 2019-nCoV;Adenitis;admixture mapping;Adult;Affect;African American;African American population;African ancestry;Alleles;American;Amino Acids;angiogenesis;Anticoagulation;Antigens;Aphthous Stomatitis;Area;Arthritis;Attenuated;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;autoinflammation;autoinflammatory;autoinflammatory diseases;Behcet Syndrome;Binding Sites;Blood;Calcinosis;Calcium;Cardiac;Cell Line;Cells;Centromere;Cervical;Child;Childhood;Chronic;CHS1 gene;Clinical;Clinical Investigator;Clone Cells;cohort;Collaborations;Complex;Coronavirus;cross reactivity;cytokine;Data;Deposition;Dermis;Diffuse;Disease;DNA;Endothelial Cells;Endothelium;Enzymes;exome;Extramural Activities;Faculty;Family;FDA approved;Fever;fibrillarin;Fibrosis;follow-up;Frequencies;Functional disorder;GDF9 gene;Gene Expression;Gene Mutation;Gene Proteins;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;Genetic study;genetic testing;genome-wide;Genomics;Genotype;Glucocorticoid Receptor;Goals;Haplotypes;high risk;Human;Incidence;Inflammation;Inflammatory;inhibitor therapy;inorganic phosphate;interest;Interleukin-1;interleukin-1 receptor accessory protein;Interleukin-1 Receptors;Interleukin-13;Investigation;Journals;Kidney;Ligands;Link;Logistic Regressions;loss of function;Lung;lymphoblastoid cell line;Manuscripts;Mediating;Medicine;Mesenchymal;Metabolism;Molecular Mimicry;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;multi-ethnic;Myelogenous;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Nature;New England;New York;NOTCH4 gene;novel;Organ;Outcome;overexpression;Paper;pathogen;Pathway interactions;Patients;Periodicals;Pharyngitis;Play;Population;Positioning Attribute;Predisposition;promoter;protein expression;Publishing;pulmonary arterial hypertension;Pulmonary Embolism;Quality of life;Race;racial difference;rare variant;receptor;Recurrence;Reporting;Research Personnel;Rheumatism;Rheumatoid Arthritis;Rheumatology;Risk;Risk Factors;risk variant;Role;Sampling;Scleroderma;Sequence Analysis;Sequence Homology;Signal Transduction;single-cell RNA sequencing;Skin;skin fibrosis;Somatic Mutation;Subcutaneous Tissue;Susceptibility Gene;Symptoms;Syndrome;System;systemic juvenile idiopathic arthritis;T cell receptor repertoire sequencing;T-Lymphocyte;tenure track;Testing;Thrombosis;Time;Tonsillar Tissue;Topoisomerase;Transcript;Tube;Ubiquitin-Activating Enzymes;Underserved Population;United States National Institutes of Health;Universities;Vacuole;Variant;Vascular Diseases;Venous;venous thromboembolism

PROJECT_TITLE: Genetic Analysis of Complex Inflammatory Disorders


NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

ORG_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PROJECT_TERMS: Adenoidectomy;Alleles;Animal Model;Animals;Apoptosis;Arthritis;Autoimmune;autoinflammation;autoinflammatory;autoinflammatory diseases;Axillary lymph node group;B-Cell Development;B-Lymphocytes;Biochemical;Biology;Case Study;CASP3 gene;CASP8 gene;Cell Death;Cell Line;checkup examination;Chronic;Clinical;clinical center;Colitis;Complex;cytokine;Data;Dermatitis;Development;Diagnosis;Disease;Ear;Enzymes;Exhibits;experimental study;Fibroblasts;Frameshift Mutation;France;Functional disorder;Genes;Genetic;Goals;Helper-Inducer T-Lymphocyte;Hereditary Disease;high dimensionality;Histologic;Homologous Gene;Homozygote;Human;Human Herpesvirus 4;immunodeficiency;Immunology;Impairment;improved;India;Inflammatory;Inherited;inhibitor;Knock-out;knockin animal;Laboratories;Lead;Link;loss of function mutation;Loss of Heterozygosity;Lymphoid Follicle;Lymphoid Tissue;Manuscripts;Marriage;member;monocyte;Mus;Mutation;Nature;NF-kappa B;Nose;Organ;Otitis Media;Paper;Parotitis;Patients;Pharyngeal structure;Phenotype;Post-Translational Protein Processing;Proteins;Publishing;Recommendation;Reporting;Resistance;RIPK1 gene;Sampling;secondary analysis;Series;sharpin;Signal Induction;Signal Transduction;skin disorder;Son;Structural Protein;Structure of germinal center of lymph node;Syndrome;Tissues;TNF gene;TNFSF5 gene;TRADD gene;TRAF2 gene;Transcend;Ubiquitin;United States National Institutes of Health;Visit

PROJECT_TITLE: Genetics, Pathophysiology, and Treatment of Recessive Autoinflammatory Diseases


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Cancer;Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PROJECT_TERMS: Acne;Acute suppurative arthritis due to bacteria;Affinity;anakinra;Animal Model;Animals;Antigen Receptors;Arthritis;Attenuated;autoinflammation;autoinflammatory diseases;B-Lymphocytes;Binding;Binding Proteins;Biology;Blood;Bone Marrow;Carcinoma;Cell Line;Clinical;Clostridium botulinum;Colitis;de novo mutation;Dermis;Development;Disease;disease model;early onset;Edema;Exanthema;exome sequencing;experimental study;Familial Mediterranean Fever;Feedback;Foundations;Functional disorder;Future;gain of function;Gene Expression Profile;Genes;Genetic;Goals;healing;Hereditary Disease;Heterozygote;Human;humoral immunity deficiency;hypogammaglobulinemia;IL18 gene;Immune;improved;In Vitro;Inflammasome;Inflammation;Inflammatory;Inherited;inhibitor;inhibitor therapy;Interferon Type I;Interferon Type II;Interleukin-1;Interleukin-1 alpha;Janus kinase;kinase inhibitor;Knock-in;Knock-in Mouse;Knock-out;knockin animal;Laboratories;Lead;Leukocytes;loss of function mutation;Loss of Heterozygosity;Lymphocyte;Lymphoma;Macrophage;marenostrin;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;mutant;Mutate;Mutation;Myeloid Cells;myeloid leukemia cell;new technology;NF-kappa B;novel;PAPA syndrome;Paper;Pathway interactions;Patients;Phenotype;PLCG2 gene;Production;Protein Dephosphorylation;Proteins;Publishing;Pyoderma Gangrenosum;Recurrence;Refractory;Reporting;Respiratory Tract Infections;retroviral transduction;Rheumatism;Safety;Sampling Studies;Serine;Sinusitis;success;T-Cell Lymphoma;T-Lymphocyte;targeted treatment;Time;TNF gene;Toxin;Variant

PROJECT_TITLE: Genetics, Pathophysiology, and Treatment of Dominant Autoinflammatory Diseases


ACTIVITY: ZIE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Rare Diseases

PI_NAMEs: KLUBO-GWIEZDZINSKA, JOANNA  (contact)

PROJECT_TERMS: accurate diagnosis;Autoimmune Diseases;autoimmune thyroid disease;Biological;Blood;Blood Tests;Board Certification;Body Composition;Cell Differentiation process;cell growth;Clinical;Clinical Data;Collaborations;Data;data exchange;Databases;Development;Diagnosis;Diagnostic Procedure;Discipline of Nuclear Medicine;Disease;Dose;Endocrine;Endocrinology;Energy Metabolism;Enrollment;Family history of;Functional disorder;Genetic;Germany;Health;HLA Antigens;human leukocyte antigen testing;Hyperthyroidism;Hypothyroidism;imaging study;Laboratory Study;Magnetic Resonance Imaging;mathematical model;Measurement;Metabolism;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;participant enrollment;patient screening;Patients;Pattern;Physical Examination;Pituitary Gland Adenoma;Protocols documentation;Public Health;Radioactive Iodine;Rare Diseases;Recording of previous events;Research Personnel;research study;Scanning;Symptoms;Technetium;Testing;Thyroid Diseases;Thyroid Function Tests;Thyroid Gland;Thyroid Hormone Resistance Syndrome;Thyroid Hormones;Thyrotropin;Thyroxine;Training;Training Programs;Transfer Agreement;treatment optimization;United States National Institutes of Health;Update;uptake;Urine;X-Ray Computed Tomography

PROJECT_TITLE: Studies of Thyroid Function in Health and Disease


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Prostate Cancer;Urologic Diseases

ORG_CITY: BATON ROUGE

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

PI_NAMEs: SU, SHANG  (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Agonist;anti-cancer research;bone;Breast Cancer Model;cancer cell;Cancer Patient;Cells;Clinical;Data;Development;Epigenetic Process;Genes;Genetic Transcription;Goals;Head and Neck Squamous Cell Carcinoma;in vivo Model;Knock-out;Malignant neoplasm of prostate;Malignant Neoplasms;Malignant Squamous Cell Neoplasm;Metastatic Neoplasm to the Bone;Neoplasm Metastasis;neoplastic cell;novel;Nuclear Receptors;overexpression;pre-clinical;prevent;prognostic;programs;Proliferating;Prostate;prostate cancer cell;Proteins;Proteomics;Relapse;response;Signal Induction;targeted treatment;Testing;therapeutic development;transcriptome sequencing;Tretinoin;tumor

PROJECT_TITLE: Deciphering Prostate Cancer Cell Dormancy Drivers