ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

PHR: The Center for Mental Healthcare & Outcomes Research (CeMHOR) is an HSR&D Center of Innovation whose mission is to optimize health and well-being of Veterans through innovative research to improve access to and engagement in evidence-based care for mental health and substance use disorders and prevent suicide. CeMHOR accomplishes its mission by partnering directly with Veterans, clinical leaders, and front-line providers to develop feasible and effective interventions to address top VA and national priorities. CeMHOR expertise in implementation science leads to widespread uptake of these interventions. CeMHOR investigators are also experts in rural health and community engagement. CeMHOR research will apply this expertise to include Veterans who are not receiving VA care, as well as those who use VA services but do not fully engage in needed care. In addition to two focus areas, mental health care access/engagement and suicide prevention, investigators conduct research to address opioid misuse and abuse and advance implementation science.

PI_NAMEs: OWEN, RICHARD R. (contact)

PROJECT_TERMS: Address;Ambulatory Care Facilities;American;Area;Arkansas;Awareness;behavioral health;career development;Caring;clay;Clergy;Clinical;Collaborations;Communities;community college;community engagement;Community Outreach;community setting;Demographer;design;Development;effective intervention;Effectiveness;Epidemiologist;Evaluation;evidence base;Federally Qualified Health Center;gaps in access;Goals;Health;health care availability;Health Services;Health Services Research;Healthcare Systems;implementation intervention;implementation science;Improve Access;improved;innovation;Intervention;Knowledge;Location;Managed Care;Medical;Mental disorders;Mental Health;mental health center;Mental Health Services;Mentors;Methods;Mind;Mission;Modeling;opioid abuse;opioid misuse;opioid use disorder;Outcomes Research;peer support;Personal Satisfaction;Pharmacists;Prevention;Prevention strategy;Primary Care;Professional counselor;programs;Provider;Psychiatrist;Psychologist;Research;Research Personnel;Resources;Risk;Rural;rural area;Rural Community;Rural Health;Science;Services;Social Workers;sociologist;Substance Use Disorder;Suicide prevention;Testing;Training;Translating;Universities;uptake;Veterans;virtual healthcare;Work


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care has had outstanding productivity and impact on Veteran healthcare and well-being through the application of the National Academy of Medicine's learning health system. In the past 3 years, our 47 investigators generated ~$47 million in operating revenue, published 583 manuscripts, and led 113 projects across our research, implementation science, operational projects/program evaluations and training programs. Our dual-site Center will continue to address our two focus areas: 1) promote Veteran-centered care to improve patient experiences across VA healthcare and community settings and 2) advanced value-driven care by providing Veterans the highest quality care at the lowest financial burden. Building on our prior success, we will continue to partner with operational leaders and our Veteran Engagement Board to innovate new research, implementation science, and operational programs as well as train the next generation of outstanding research leaders.

PI_NAMEs: AU, DAVID H (contact);HO, P. MICHAEL

PROJECT_TERMS: Academy;Address;Area;Award;care delivery;career development;Caring;clinical care;Colorado;Communities;community setting;Complex;Congresses;Deimplementation;disparity elimination;Evaluation;experience;Faculty;Financial Hardship;Funding;geographic disparity;health care service;health care settings;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;improved outcome;innovation;Intervention;Knowledge;Lead;Learning;Manuscripts;Medical center;medical specialties;Medicine;Mental Health Services;Methods;Mission;next generation;novel strategies;Paper;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Policies;Postdoctoral Fellow;Primary Care;primary health service;Productivity;Program Evaluation;programs;Provider;Psyche structure;Publishing;Quality of Care;Research;research clinical testing;Research Personnel;Rural Health;Safety;satisfaction;Self Management;Site;socioeconomic disparity;sound;Statutes and Laws;success;Suicide prevention;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Veterans;Washington;Women's Health;Work;Workforce Development

PROJECT_TITLE: Seattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care

STUDY_SECTION_NAME: HCN1 COIN REVIEW[HCN1]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of the Durham Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT) is to enhance the Veterans Health Administration's (VHA) ability to continually improve health care and optimize Veteran wellbeing and independence. ADAPT will lead innovative research on promoting and sustaining healthy lifestyles, improving access through virtual care, and optimizing Veteran function and independence. Working closely with VA and non-VA partners, ADAPT investigators will apply and advance state-of-the-art methods, translate research findings into meaningful practice change, and train the next generation of VA researchers. ADAPT will play a vital role in helping VHA meet the challenges of providing timely, coordinated, consistently high-quality care to more than 9 million Veterans each year.

PI_NAMEs: HASTINGS, SUSAN NICOLE (contact)

PROJECT_TERMS: Acceleration;Address;Area;Behavior;burden of illness;care systems;career development;Caring;Clinical;clinical care;Collaborations;Communities;Data Sources;design;Development;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;Ensure;experience;Face;Family;Fostering;Funding;Goals;Grant;Health behavior;health care availability;health care service organization;Health Services;Health Services Research;Health system;Healthcare;Healthcare Systems;healthy lifestyle;implementation research;Improve Access;improved;Individual;innovation;Lead;Leadership;Life;Long-Term Care;Mentorship;Methods;Modeling;Names;next generation;novel;Observational Study;Personal Satisfaction;Phase;Physicians;Pilot Projects;Play;Policies;Postdoctoral Fellow;Pragmatic clinical trial;Process;Quality of Care;Recording of previous events;Research;research and development;Research Infrastructure;Research Personnel;research study;resilience;Resources;Role;routine practice;Science;social factors;Time;Training;Translating;Translations;Veterans;Veterans Health Administration;virtual healthcare;Work;World Health Organization


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Not applicable.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Area;career development;Caring;Collaborations;Decision Making;Dissemination and Implementation;empowerment;Ensure;experience;Faculty;falls;Family;Feedback;Fellowship;Goals;Health;Health Services Research;Healthcare;Healthcare Systems;improved;innovation;Malignant neoplasm of lung;member;Mental Health;Methodology;Mission;non-opioid analgesic;operation;Opioid;Oregon;Pain;Pain management;Patient-Centered Care;Personal Satisfaction;prescription opioid;Process;Research;Research Methodology;Research Personnel;Safety;Science;Self Care;Site;Substance Use Disorder;Suicide prevention;Support System;Technology;Universities;Veterans;whole health

PROJECT_TITLE: Center to Improve Veteran Involvement in Care (CIVIC)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PI_NAMEs: ORELLANA VINUEZA, ESTEBAN ANDRES (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Antisense Oligonucleotides;Arginine Specific tRNA;Awareness;cancer therapy;Catalytic Domain;Characteristics;Codon Nucleotides;Complex;Deposition;Excision;Failure;Goals;Growth;Homeostasis;Human;human disease;insight;Knock-out;Malignant - descriptor;Malignant Neoplasms;malignant phenotype;Measures;Mediator;Modeling;Modification;Monitor;mRNA Translation;neuron development;novel;Oncogenes;Oncogenic;Pathologic Processes;Pathway interactions;Physiology;Protein Biosynthesis;Protein Isoforms;Proteins;Quality Control;Reaction;Regulation;Reporter;RNA;RNA Decay;RNA Degradation;RNA Folding;RNA metabolism;RNA methylation;RNA Stability;Role;Sarcoma;Shapes;System;Testing;Therapeutic;Transfer RNA;Translations;tRNA Methyltransferases;tumorigenesis;whole genome;Work;Yeasts

PROJECT_TITLE: Dysregulation of tRNA: a new paradigm for cancer therapies


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Myocardial infarction (MI) can lead to heart failure (HF), which negatively impacts the quality of life of millions of Americans. This study will use a novel computational stability analysis to investigate the mechanisms that lead to post-MI HF by examining how biomechanical stimuli can impair cardiac function through growth and remodeling. Results will identify HF risk factors and promote the development of diagnostics and therapeutics to detect and ultimately prevent HF.

PI_NAMEs: PFALLER, MARTIN R (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: American;biobank;Biology;Biomechanics;Calibration;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Models;Cardiovascular system;career;career development;Cell model;Cells;Clinical;Clinical Data;clinical decision-making;clinical predictors;clinical translation;Collagen;Compensation;Computer Models;Confidence Intervals;Data;Data Set;Development Plans;Diagnostic;diagnostic development;Dimensions;Elastin;Engineering;Environment;Equilibrium;extracellular;Family suidae;Feedback;Fibrosis;Foundations;Funding;Genetic;Goals;Growth;Heart;Heart Diseases;Heart failure;heart function;hemodynamics;Homeostasis;Human;human subject;Impairment;improved;in vivo;Infarction;insight;kinematics;Knowledge;Left ventricular structure;Link;Location;Measurement;Mechanics;Medical Device Designs;Medical Imaging;Mentors;Modeling;multi-scale modeling;Muscle Cells;Myocardial Infarction;Myocardial tissue;Myocardium;neglect;novel;Organ;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized diagnostics;personalized medicine;Phase;Physiologic intraventricular pressure;Prediction of Response to Therapy;predictive modeling;pressure;prevent;Process;Productivity;Property;Publications;Publishing;Quality of life;Records;Research;Resources;Risk;Risk Factors;Sarcomeres;Scientist;Shapes;skills;Stimulus;Structure;targeted treatment;Testing;theories;Therapeutic;Time;Tissues;Training;Universities;Validation;Ventricular;virtual environment

PROJECT_TITLE: Computational Stability Analysis to Predict Heart Failure after Myocardial Infarction

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Defective hematopoiesis is a hallmark of blood diseases, many of which are enriched with Dnmt3a mutations and are associated with an enhanced inflammatory milieu. This project will generate an improved understanding of the mechanism(s) by which Dnmt3a mutations endow a fitness advantage to hematopoietic stem cells (HSCs) during chronic inflammation, which remodels bone marrow composition and reinforces further selections of the mutant HSCs for disease progression. Results generated from this study will likely lead to therapeutic opportunities that allow early interventions of DNMT3A-mutant clonal hematopoiesis-associated blood diseases.

PI_NAMEs: ZHANG, CHRISTINE R (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Accounting;Address;Age;age related;Aging;aging population;Anemia;Aplastic Anemia;Architecture;Autoimmune;Award;biochemical tools;biological adaptation to stress;Blood;Blood Platelets;Bone Marrow;Bone Marrow Cells;Bone remodeling;cardiovascular disorder risk;career;career development;Cell Compartmentation;Cells;Chromatin;Chronic;Clinical;Clonal Expansion;Clonal Hematopoietic Stem Cell;Data;Development;Development Plans;Disease;disease phenotype;Disease Progression;DNA Modification Methylases;DNMT3a;DNMT3a mutation;Dysmyelopoietic Syndromes;Early Intervention;Elderly;Endowment;Ensure;Epigenetic Process;Erythrocytes;Erythroid;Erythroid Progenitor Cells;Evolution;experience;Exposure to;fitness;Genes;Genetic;genetic manipulation;Goals;Grant;Hematological Disease;Hematology;Hematopoiesis;hematopoietic stem cell quiescence;Hematopoietic stem cells;Imaging Device;improved;Indolent;Infection;Inflammation;inflammatory milieu;innovation;Interferon Type II;Knowledge;Laboratories;Lead;Lesion;Link;medical schools;Megakaryocytes;Mentors;microbial;Modeling;Molecular;multiple omics;multiplexed imaging;Multipotent Stem Cells;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutate;Mutation;myelodysplastic anemia;Obesity;Outcome Study;overexpression;Pathology;Pathway interactions;Persons;Phenotype;Postdoctoral Fellow;pressure;Prevalence;Property;reconstitution;Recurrence;Research Personnel;response;Risk;Risk Reduction;Running;Serum;Shapes;Signal Transduction;skills;Somatic Mutation;stem cell biology;stem cell population;stem cells;Stress;success;Symptoms;T-Lymphocyte;Technical Expertise;Techniques;Testing;Therapeutic;TP53 gene;Training;transcriptome;Transplantation;trend;Universities;Up-Regulation;Variant;Washington

PROJECT_TITLE: Integration of HSC Stress Responses and Disease Progression by DNMT3A Mutations


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Sleep Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Public Health Statement: Obesity and Alzheimer’s disease (AD) devastate millions of Americans and place a tremendous burden on our healthcare system. Necessities of modern society put immense pressure on human physiology by forcing incongruity between endogenous circadian rhythms and environmental cycles, which worsens a range of health issues including obesity associated maladies and AD. This project aims to identify the neuronal circuits and the molecular players that control circadian rhythms and therefore identify therapeutic targets to circumvent these pathologies.

PI_NAMEs: GULER, ALI  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;adverse outcome;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;Astronomy;Behavior;behavioral response;Biological Process;circadian;Circadian desynchrony;circadian pacemaker;Circadian Rhythms;Cues;Diet;Dopamine Receptor;Dopaminergic Cell;dopaminergic neuron;Event;Exercise;Food;Food Access;food consumption;food restriction;Genetic Transcription;Goals;Health;Healthcare Systems;high risk;Hour;Human;Hypothalamic structure;insight;Laboratories;Light;Lighting;Metabolic;Metabolic Diseases;Metabolic dysfunction;Midbrain structure;Modernization;Molecular;mouse model;neural circuit;Neurodegenerative Disorders;neuronal circuitry;Neurons;novel;Obesity;Pathology;Pathway interactions;Periodicity;Persons;Physiological;Physiology;pressure;Prevalence;Public Health;Recurrence;reduce symptoms;response;Rewards;Signal Transduction;Social Interaction;Societies;Stress;suprachiasmatic nucleus;Target Populations;therapeutic target;Time;Weight Gain;Work

PROJECT_TITLE: Interplay between circadian and reward pathways in homeostatic response and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Atherosclerosis;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Pneumonia is the leading cause of infection-related deaths worldwide, necessitating a greater understanding of the mechanisms that regulate immune defense and tissue recovery in the lung post-infection. Lectin-like oxidized low-density receptor-1 (LOX-1) is a C-type lectin scavenger receptor that has a unique function in the lung, whereby it is protective against edematous lung injury and inflammation through alterations in leukocyte response that suggests a more pro-resolving phenotype. Whether and how LOX-1 promotes resolution of infection in the lung via resident and recruited leukocytes is not known and is the subject of the proposed studies, where effects of LOX-1 signaling will be investigated at the transcriptional (K99), metabolic (R00) and phenotypic level (K99/R00).

PI_NAMEs: KORKMAZ, FILIZ  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Alveolar Macrophages;Anticholesteremic Agents;Atherosclerosis;Bacteria;Binding;Biological;Biology;Blood;Bronchoalveolar Lavage Fluid;C-Type Lectins;career;Cell Respiration;cell type;Cells;Cessation of life;Chimera organism;cholesterol biosynthesis;Cholesterol Homeostasis;COVID-19 pandemic;Curiosities;Data;Diabetes Mellitus;Diagnosis;Ensure;Escherichia coli;Exhibits;fatty acid oxidation;Gene Expression Regulation;Genes;Genetic Transcription;Glycolysis;Health;Hematopoietic;Homeostasis;Immune;immune function;Immune response;Immune signaling;immunoregulation;in vivo;Infection;Inflammation;Inflammatory;Injury;insight;Investigation;Knockout Mice;Knowledge;Lectin;Leukocytes;Life;Ligands;Link;lipid metabolism;Low Density Lipoprotein Receptor;LOX gene;Lung;lung injury;Macrophage;Mediating;Metabolic;Metabolic Pathway;Metabolism;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;neutrophil;Neutrophil Infiltration;Obesity;oxidized low density lipoprotein;pathogen;Patients;Phenotype;Pilot Projects;Pneumonia;Predisposition;prevent;Process;programs;protective effect;PTPRC gene;pulmonary function;Pulmonary Inflammation;receptor density;Recovery;recruit;repaired;Research;Resistance;Resolution;response;Role;scavenger receptor;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Source;Streptococcus pneumoniae;Testing;tissue injury;Tissues;tool;Training;vascular inflammation

PROJECT_TITLE: Establishing Mechanisms of LOX-1-Dependent Immune Regulation During Pneumonia


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Type 2 diabetes mellitus (T2DM) is an independent risk factor for future cardiovascular events, often preceded by microvascular endothelial dysfunction. Endothelial function has been demonstrated to be regulated by autophagy, but there is little understanding of the mechanistic role of autophagy within the T2DM microvasculature. The overall goal of this application is to determine the fundamental mechanisms contributing to microvascular dysfunction in T2DM, we hypothesize that impaired autophagic flux mechanistically contributes to microvascular dysfunction through alterations in Transcription Factor EB in T2DM.

PI_NAMEs: HUGHES, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Adult;Agonist;Animal Model;Arteries;arteriole;Autophagocytosis;Basic Science;Biogenesis;Blood Vessels;Cardiomyopathies;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;career;career development;Chloroquine;Clinical;Clinical Sciences;Clinical Trials;Collaborations;Complement;Coupled;Cutaneous;Data;Defect;Development Plans;Diabetes Mellitus;Dilator;Disease;Disease Progression;Education;endothelial dysfunction;Endothelium;Ensure;Environment;Event;experience;Exposure to;Faculty;Functional disorder;Future;gene repression;Genetic;Glucose;Goals;Health;Human;Human Subject Research;Hydrogen Peroxide;Hyperemia;Hyperglycemia;Impairment;in vivo;inhibition of autophagy;Investigation;Knowledge;Laboratories;Laser-Doppler Flowmetry;Lasers;Learning;Lysosomes;Maintenance;Mediating;Mediator;Mentors;Mentorship;Microcirculation;Microdialysis;Microvascular Dysfunction;microvascular pathology;Mitochondria;Molecular;mortality;multidisciplinary;Nature;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;overexpression;Oxidation-Reduction;Oxidative Stress Induction;Pathologic;pharmacologic;Phase;Physiological;Physiology;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;preservation;Production;programs;Reactive Oxygen Species;Repression;Research;Research Personnel;Resistance;response;Retinal Diseases;Risk Factors;Role;sabbatical;Science;Scientist;Senior Scientist;Series;shear stress;skills;Technical Expertise;Techniques;Training;transcription factor;Translating;translational model;translational study;Trehalose;Vascular Diseases;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Viral

PROJECT_TITLE: Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction


ADMINISTERING_IC: CA

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NORFOLK

ORG_NAME: OLD DOMINION UNIVERSITY

PHR: Project Narrative Smoke-free public housing policies have been mandated by the U.S. Department of Housing and Urban Development (HUD). However, our work suggests these policies are considered to be so unfair by residents that compliance is severely undermined, with potentially negative unintended consequences. Our goal is to verify how these policies can be harmful and propose adaptations to increase their effectiveness.

PI_NAMEs: ENGLAND, KELLI ;SHEEHAN, BRYNN  (contact)

PROGRAM_OFFICER_NAME: LAND, STEPHANIE R

PROJECT_TERMS: Affect;Air;Area;Attitude;authority;Biological Markers;Communities;community advisory board;community based participatory approach;community based participatory research;Disease;Effectiveness;Environment;environmental tobacco smoke;environmental tobacco smoke exposure;Exhalation;Exhibits;experience;fine particles;Focus Groups;Fright;Goals;Group Interviews;Health;health disparity populations;Housing;implementation framework;implementation strategy;improved;Individual;Institution;Intervention;Interview;Justice;Laws;Left;Legitimacy;Low income;Measures;Mediating;member;Methods;metropolitan;Modeling;Monitor;Nicotine;Outcome;Perception;Persons;Policies;prevent;Process;Property;Proxy;Public Housing;Punishment;Recommendation;Reporting;response;Rights;Risk;Sampling;Smoke;Smoke-free home;Smoker;Smoking;soda tax;Surveys;Testing;theories;Tobacco;Trust;U.S. Department of Housing and Urban Development;Walking;willingness;Work

PROJECT_TITLE: Using Differences in Perceived Legitimacy and Resident Compliance to Promote Fair and Effective Implementation of Smoke Free Housing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DIRH-N(09)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: AUSTIN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE  Exposure to elevated manganese (Mn) induces incurable neurotoxicity in humans that manifests as parkinsonism in adults, and motor and executive function deficits in children. This study will determine the role of Mn excretion in regulating the risks and outcomes of Mn neurotoxicity. Proposed work will also determine whether increasing Mn excretion is a therapeutically-viable strategy for the management of Mn-induced neurological disease.

PI_NAMEs: MUKHOPADHYAY, SOMSHUVRA  (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Address;Adult;Affect;Bile fluid;Biological Assay;Blood;Body Burden;Brain;brain control;Child;Clinical;Clinical Trials;Development;Disease;Dose;drinking water;epidemiology study;Excretory function;Executive Dysfunction;Exhibits;exposed human population;Exposure to;Feces;Future;gastrointestinal system;General Population;Genetic Polymorphism;Genetic Transcription;Genetic Variation;Hepatic;HIF1A gene;High Prevalence;Human;human model;Individual;Inherited;insight;Intestines;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Life;Liver;Liver diseases;loss of function;loss of function mutation;Manganese;Mediating;Metals;Microscopy;Modeling;Molecular;Motor;motor disorder;National Institute of Environmental Health Sciences;Nervous System Disorder;neurobehavioral;neurotoxic;neurotoxicity;Neurotransmitters;novel;novel therapeutic intervention;Occupational Exposure;Oral;Organ;Organism;Outcome;Parkinsonian Disorders;Pathway interactions;Patients;Phase;Play;Population;prevent;protective effect;Regimen;Reporting;Research;response;Risk;Role;Single Nucleotide Polymorphism;Source;Testing;Therapeutic;therapeutically effective;Tissues;Toxic effect;Up-Regulation;Variant;Work

PROJECT_TITLE: Role and mechanisms of excretion in manganese neurotoxicity

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE  Markey Cancer Center is the only NCI-designated Comprehensive Cancer Center in the state of Kentucky, and its catchment area includes all 120 counties in Kentucky. The mission of Markey Cancer Center is to reduce cancer burden, which necessitates translating scientific discoveries into innovative, personalized care and providing the highest quality care to cancer survivors. This administrative supplement aims to assess alignment between survivorship care at Markey Cancer Center and the National Standards for Cancer Survivorship Care, identify determinants of survivorship care access for survivors and their caregivers, and identify implementation strategies to improve quality, effectiveness, adoption, and reach of survivorship care at Markey.

PI_NAMEs: EVERS, BERNARD MARK (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Administrative Supplement;Administrator;Adoption;Award;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer site;Cancer Survivor;cancer survivorship care;Caregivers;Caring;Catchment Area;community engagement;Comprehensive Cancer Center;County;Data;Disease;Education;Effectiveness;expectation;Geography;Goals;Health Services Accessibility;implementation strategy;improved;Incidence;innovation;interest;Kentucky;member;Methods;Mission;mortality;National Cancer Institute;Outcome;Participant;patient oriented;personalized care;personalized diagnostics;personalized medicine;Phase;Practical Robust Implementation and Sustainability Model;Prevention;Provider;Quality of Care;Reporting;Research;residence;response;Survivors;survivorship;Translating;Universities;Vulnerable Populations

PROJECT_TITLE: Assessing Markey Cancer Center's Alignment with National Standards for Survivorship Care


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Health Services;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

ORG_STATE: CA

PHR: This project is directly relevant to public health concerns related to the effects of prenatal alcohol exposure on child health and development. This study aims to improve the screening of FASD by deploying web-based tools that aid in clinical evaluation. Two main tools will be used, the FASD-Tree and the Brief Assessment of Individual Neurobehavior – online version (BRAIN-online). Both tools use web-based technology for collecting data and provide the clinician with information about the individual’s physical, behavioral, and cognitive attributes. Data from these novel tools will be combined with traditional and advanced physical measurements collected through other CIFASD projects and will enhance clinical decision-making.

PI_NAMEs: MATTSON WELLER, SARAH N (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Affect;Age;Alaska;Alcohol-Related Neurodevelopmental Disorder;Alcohols;Attention;Behavior;Behavioral;brief screening;Canada;Child;Child Development;Child Health;Classification;classification trees;Clinic;Clinical;clinical decision-making;clinical diagnosis;Cognitive;cognitive testing;Collaborations;Computers;cost;cost effective;Data;demographics;Detection;Diagnostic;diagnostic tool;Dysmorphology;Electronic Mail;Evaluation;Face;Feedback;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;high risk;Home;Image;Imaging Device;improved;Impulsivity;Individual;interest;Intervention;Link;Measurement;Measures;medical specialties;Memory;Minnesota;Motor;neurobehavior;Neuropsychological Tests;Neuropsychology;novel;Online Systems;online version;Outcome;Output;Parents;Patients;Performance;Persons;Phase;Physical Examination;prenatal testing;Problem Solving;Process;processing speed;Public Health;Questionnaires;Reaction Time;Records;recruit;Research;research clinical testing;Research Personnel;Resources;response;Risk;Sample Size;Sampling;screening;Screening procedure;Short-Term Memory;social media;special interest group;Specificity;Speed;Standardization;System;Technology;Telemedicine;Test Result;Testing;tool;Training;transcranial direct current stimulation;Trees;Visit;Wait Time;web-based assessment;web-based tool;Youth

PROJECT_TITLE: Assessment of Fetal Alcohol Spectrum Disorders (FASD) Using Novel Web-Based Tools


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Even after completing cancer treatment, cancer survivors have increased health risks compared with the general population, necessitating ongoing care through survivorship programs. This project will assess Dartmouth Cancer Center’s survivorship services against a new set of national standards for survivorship programs to identify areas where Dartmouth Cancer Center’s program can be enhanced to meet rural survivors’ needs and engage them in care through digital tools and other innovative solutions. The project will produce a set of recommendations for quality improvement initiatives to support lasting impacts on survivorship care delivery and outcomes for survivors in rural areas.

PI_NAMEs: LEACH, STEVEN D (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Activities of Daily Living;Age;Area;Cancer Center;Cancer Center Support Grant;cancer recurrence;cancer risk;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;care delivery;care outcomes;Caring;Catchment Area;Characteristics;Clinical;Comprehensive Cancer Center;Consensus;digital delivery;digital health;digital tool;Ensure;Equipment and supply inventories;follow-up;Gender;General Population;Health;Health Services Accessibility;improved;improved outcome;Incidence;innovation;interest;Intervention;Interview;Malignant Neoplasms;Mental Health;Outcome;Patients;Personal Satisfaction;Persons;Population;programs;Quality of life;Recommendation;response;Risk;Rural;rural area;rurality;Scanning;Services;Surveys;Survivors;survivorship;telehealth;Time;tool;Translations;Transportation;Travel;treatment effect

PROJECT_TITLE: Cancer Center Support Grant - Gunn Supplement


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: EXPOSURE: Project Narrative Although engagement in long-term follow-up survivor care is critical to the lifelong health of the growing childhood cancer survivor (CCS) population, >25% of CCS are not accessing survivor care nationally. Understanding the factors impacting the landscape of pediatric survivor care (e.g., institutional uptake of standards, population reach, patient engagement) may reduce gaps in care delivery for CCS. The objectives of this supplement to the Winship Cancer Institute's NCI-designated P30 Cancer Center grant are to examine: 1) the alignment of the care offered to pediatric CCS with the National Standards for Survivorship Care, 2) the long-term utilization of pediatric survivor services, and 3) patient- and family-level factors related to long-term engagement in survivor care.

PI_NAMEs: RAMALINGAM, SURESH S (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Address;Administrative Supplement;Adult;Age;aged;Area;Cancer Center;Cancer Intervention;Cancer Survivor;cancer survivorship care;care delivery;care providers;care systems;Caregivers;Caring;Characteristics;Child health care;Childhood;childhood cancer survivor;Chronic;Clinic Visits;cohort;Data;Dedications;deprivation;design;Development;Diagnosis;Early Diagnosis;Early treatment;Eligibility Determination;Ethnic Origin;Evaluation;Evidence based intervention;experience;Family;Future;Gender;Geographic Locations;Grant;Health;health belief;Health Personnel;Health system;Healthcare;Hematological Disease;improved;indexing;Institution;Insurance Coverage;interest;Interview;Jordan;Knowledge;Language;Late Effects;Leadership;Long-Term Care;Longterm Follow-up;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical Records;Mental Health;Methods;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;Oncology;patient engagement;Patient Outcomes Assessments;Patients;Pediatric cohort;Pediatric Oncology;Pediatric Oncology Group;pediatrician;physical conditioning;Policies;Population;Process;Program Development;programs;psychosocial;quality of life for cancer survivors;Race;Recommendation;Reporting;response;Risk;secondary analysis;Services;Site;Survivors;survivorship;therapy design;Time;uptake;Visit;Work;young cancer survivor

PROJECT_TITLE: Administrative Supplement: Assessing and Enhancing Survivorship Care


NIH_SPENDING_CATS: Cancer;Clinical Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The Atrium Health Wake Forest Baptist Comprehensive Cancer Center (AHWFBCCC) catchment area includes 4.8 million residents, about one-third racial/ethnic minority, and a significant rural footprint. The proposed work will evaluate the extent to which survivorship care programs in this multidimensional health care system align with recently developed National Standards for Survivorship Care through a mixed-methods action planning process that considers different contexts in depth and will inform future implementation of optimized survivorship care. Establishing a systematic process for assessing and improving accessible survivorship care with a balance of common unified services and variations tailored to local demands will position AHWFBCCC to contribute to a broader understanding of what survivorship care models are optimally effective in diverse populations.

PI_NAMEs: MESA, RUBEN A. (contact)

PROJECT_TERMS: Administrative Supplement;American;Area;Award;Baptist Church;Cancer Center;Cancer Center Support Grant;Cancer Survivorship;cancer survivorship care;Caring;Catchment Area;Clinic;clinical care;Communities;community advisory board;community engagement;Community Outreach;Comprehensive Cancer Center;contextual factors;County;Data;design;Dimensions;Electronics;Equilibrium;ethnic minority;Ethnic Origin;Future;future implementation;Geographic Locations;Goals;Health;Healthcare Systems;Heart Atrium;improved;improved outcome;insight;interest;Interview;Malignant Neoplasms;Methods;Modeling;National Cancer Institute;North Carolina;Patients;Phase;Population Heterogeneity;Positioning Attribute;Process;Process Assessment;programs;Race;racial minority;response;Rural;Science;Services;Site;South Carolina;Structure;Surveys;survivorship;systematic review;Variant;Work

PROJECT_TITLE: Administrative Supplement for Assessing and Enhancing Survivorship Care


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE This study will comprehensively evaluate and refine a tool, named the Suspected Potential Overdose Tracker (SPOT), that uses data routinely collected during death investigations to identify accidental drug overdose as the cause and manner of death in near real-time. Near real-time data on overdose deaths will allow for data- driven decision making, the identification of gaps in public health and public safety overdose response preparedness, and opportunities to evaluate overdose prevention interventions, programs, and policies.

PI_NAMEs: HOCHSTATTER, KARLI RAE (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Accidents;Address;Adopted;Affect;Age;Algorithms;Benchmarking;Certification;Cessation of life;Collaborations;Color;Communities;Coroners and Medical Examiners;County;dashboard;Data;Data Element;data visualization;Death Certificates;Death Rate;Decision Making;Detection;Epidemic;Epidemiology;Ethnic Origin;Evaluation;Family;Foundations;Friends;Funding;Geographic Locations;Goals;healing;Health;high risk;Hour;improved;Information Systems;Interview;Investigation;Measures;Medical;Medical Examiners;Methodology;Methods;mortality;Names;National Institute of Drug Abuse;Natural Language Processing;New York;New York City;opioid epidemic;outreach;Overdose;overdose death;overdose prevention;overdose risk;Pattern;Performance;Persons;Pharmaceutical Preparations;Play;Policies;Predictive Value;Preparation;prevent;preventive intervention;programs;prospective;Public Health;Race;Readiness;real time monitoring;Reporting;Reproducibility;Research Personnel;Research Priority;response;Role;Safety;Science;sex;Social Network;Structure;substance use;surveillance data;Techniques;Time;tool;Translating;trend;usability;user centered design

PROJECT_TITLE: Addressing substance use among the social networks of suspected drug overdose decedents: rapidly translating epidemiology into prevention intervention science


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Physical Injury - Accidents and Adverse Effects

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Public exposure to radiation due to large-scale radiation incidents is a rising global concern, but there are no FDA-approved therapeutics for radiation injury. Therefore, we propose to conduct studies to uncover the cellular and molecular mechanisms involved in radiation-induced innate immunity dysfunction. The outcome of these studies will identify a new medical countermeasure to treat radiation injury by targeting innate immune dysfunction.

PI_NAMEs: RAO, RADHAKRISHNA  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: alpha-Defensins;Anti-Bacterial Agents;anti-microbial peptide;Attenuated;Bacteria;base;Biology;Bone Marrow;Cell Physiology;Cell secretion;Clinical;Colitis;cryptdin;Data;Defensins;Diet;Dose;Down-Regulation;dysbiosis;Effectiveness;Endotoxemia;Enterobacteriaceae;Epithelial Cells;Epithelium;Exposure to;FDA approved;fecal transplantation;Fibroblasts;Functional disorder;gastrointestinal;gastrointestinal epithelium;Goals;Growth;gut dysbiosis;gut microbiota;Homeostasis;Human;Immune;Immune System Diseases;Impairment;Inflammatory Response;insect defensin A;intestinal crypt;intestinal epithelium;Intestinal Mucosa;Intestines;Ionizing radiation;irradiation;Knockout Mice;Mediating;medical countermeasure;Messenger RNA;metatranscriptome;microbiota;microbiota composition;Molecular;Morbidity - disease rate;mortality;mouse model;Mucosal Immune System;Mucosal Immunity;Mucositis;Mucous Membrane;multiorgan injury;Mus;Natural Immunity;novel;Outcome Study;Paneth Cells;pathobiont;pathogen;Pathogenesis;Pathway interactions;Peptides;Predisposition;Production;Protein Isoforms;Qualifying;Radiation;Radiation Accidents;Radiation Dose Unit;radiation effect;Radiation exposure;Radiation Injuries;radiation mitigation;Radiation Toxicity;Research;response;RNA;Rodent;Role;Salmonella typhimurium;Small Intestines;subcutaneous;Supplementation;Survival Rate;systemic inflammatory response;TCF7L2 gene;Testing;Therapeutic;Time;transcription factor;WNT Signaling Pathway

PROJECT_TITLE: Radiation-Induced Paneth Cell Dysfunction


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVES LMNA-related dilated cardiomyopathy (LMNA-DCM) is one of the most prevalent forms of inherited heart disease. This study will investigate the molecular mechanisms of DCM by examining how crosstalk signaling among cardiomyocytes, endothelial cells, and cardiac fibroblasts via secreted proteins may contribute to the pathogenesis of LMNA-DCM. The proposed studies will provide insight into disease mechanisms and inform the development of new therapies that target intercellular signaling pathways in DCM.

PI_NAMEs: WONG, WING H.;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: 3-Dimensional;Affinity;Algorithms;aptamer;Base Pairing;Biological Assay;Calcium;candidate selection;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cell Communication;Cell Differentiation process;cell type;Cells;cellular targeting;Chemicals;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complement;coronary fibrosis;Defect;Development;Dilated Cardiomyopathy;Disease;drug candidate;druggable target;Electrophysiology (science);Endothelial Cells;endothelial dysfunction;Fibroblasts;Fibrosis;Fluorescence;Functional disorder;Funding;gain of function;Gel;Genes;Genome;genome editing;Heart;heart cell;Heart Diseases;Heart failure;high throughput screening;Human;human induced pluripotent stem cells;imaging system;improved;in vitro Model;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;intercellular communication;Investigation;Journals;Libraries;Ligands;loss of function;Maps;Medicine;Methods;Modality;Modeling;Molecular;Morphology;mutant;Mutation;Nature;new therapeutic target;novel therapeutic intervention;optical imaging;Organoids;Paper;Pathogenesis;Pathology;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Protein Secretion;Proteomics;Protocols documentation;Publications;Publishing;Qi;receptor;Reporter;Reporting;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cells;Technology;Tube;Variant;Ventricular;virtual;Wing

PROJECT_TITLE: Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: WAYNE

ORG_NAME: PALVELLA THERAPEUTICS, INC.

ORG_STATE: PA

PHR: FOA Number: RFA-FD-23-001 FOA Title: Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) Clinical Trials Required Proposal Title: SELVA: A Multicenter, Phase 3 Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX- 022 in the Treatment of Microcystic Lymphatic Malformations Institute: FDA Office of Orphan Products Development Study Section: N/A Project Narrative This application proposes to develop a novel pathologically targeted therapy for a rare genetic disease called microcystic lymphatic malformations (microcystic LM). Microcystic LM is caused by mutations in the PI3K/mTOR signaling pathway, resulting in abnormal lymphatic vessel formations that result in cutaneous lesions. Palvella Therapeutics plans to treat microcystic LM with PTX-022, a topical gel that targets the root cause of microcystic LMs, by downregulating excessive mTOR signaling at the site of disease.

PI_NAMEs: MARTINI, JEFF  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, LLOYD

PROJECT_TITLE: SELVA: A Multicenter, Phase 3 Baseline-Controlled Study Evaluating the Safety and Efficacy of PTX-022 in the Treatment of Microcystic Lymphatic Malformations

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-S (01)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE This proposal aims to investigate the level of alignment between the survivorship services provided by a comprehensive cancer center and the National Standards for Survivorship Care. Additionally, it will analyze the utilization rates of the Survivorship Clinic among a sample of adolescent and young adult cancer survivors who were initially eligible to take part in a randomized trial involving a mobile app and website designed to reduce distress and enhance adherence to healthcare in the parent grant. Lastly, qualitative interviews will be conducted with a subset of AYA participants to explore their experiences and the barriers and facilitators they encountered in accessing survivorship-focused care.

PI_NAMEs: BAKER, KEVIN S (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Adherence;Administrative Supplement;Adolescent;Adolescent and Young Adult;Age;Agreement;Cancer Center;Cancer Survivor;cancer survivorship care;care delivery;care systems;Caring;Clinic;Comprehensive Cancer Center;Comprehensive Health Care;Data;design;Diagnosis;Distress;Eligibility Determination;Emotional;experience;Goals;Healthcare;improved;interest;Interview;Leadership;Malignant Neoplasms;meetings;Methods;mobile application;parent grant;Participant;patient oriented;programs;randomized trial;response;Sampling;Services;social;Structure;Supportive care;Survivors;survivorship;telehealthcare;Testing;Underserved Population;web site;young adult

PROJECT_TITLE: Improving Survivorship Care for Adolescents and Young Adults: a Mixed Methods Study of Alignment with the National Standards for Survivorship Care


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: [No Change Proposed by Supplement Activities]  PROJECT NARRATIVE The proposed project maps out the developmental trajectories of spatial hearing abilities in complex reverberant environments for school-age children with normal hearing. Findings of this work will provide intervention benchmarks to guide the fitting of bilateral hearing devices (e.g., cochlear implants and hearing aids) for children with hearing loss.

PI_NAMEs: PENG, ZHAO ELLEN (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 12 year old;18 year old;5 year old;9 year old;Address;Adult;Affect;Age;Area;Auditory;Auditory Perception;auditory processing;Benchmarking;Bilateral;Binaural;Child;Cochlear Implants;Communication;Complex;Cueing for speech;Cues;Data;Development;Devices;educational atmosphere;Environment;Foundations;Goals;Hearing;Hearing Aids;hearing impairment;Hearing Tests;Image;Impairment;improved;innovation;Intervention;Knowledge;Learning;Life;Maps;Measures;National Institute on Deafness and Other Communication Disorders;noise perception;normal hearing;novel;object perception;Outcome;Outcome Measure;Pattern;Perception;Performance;precedence effect;prevent;Process;Psychophysics;Role;school environment;School-Age Population;Severities;Signal Transduction;Size Perception;skills;Social Interaction;sound;Source;Speech;speech in noise;Speech Perception;Surface;Testing;Time;virtual;virtual reality;Width;Work

PROJECT_TITLE: ADMIN SUPPLEMENT: DEVELOPMENT OF FUNCTIONAL SPATIAL HEARING IN REVERBERATION

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Sulfur mustard (mustard gas) and arsenicals such as lewisite still represent major threats as vesicant agents in chemical warfare and terrorism. We plan to test a new antioxidant as a countermeasure and to investigate the initiation of vesicant skin injury at a subcellular and single cell level to help develop better treatment for vesicant exposures.

PI_NAMEs: ANDERSEN, BOGI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Abbreviations;Acetylcysteine;Animal Model;Antioxidants;Arsenicals;Basal lamina;Biochemical;Bulla;cell injury;Cells;Chemical Structure;Chemical Warfare;Chromatin;cobinamide;Collagen;Cyclic GMP-Dependent Protein Kinases;Dermal;effectiveness testing;efficacy testing;Epidermis;experimental study;fluorescence lifetime imaging;Foundations;Genes;Genetic Transcription;Genomics;Goals;Histologic;Human;Image;Imiquimod;in vivo;in vivo evaluation;in vivo fluorescence;Injury;innovation;insight;Interferons;keratinocyte;Knowledge;Langerhans cell;Late Effects;Lead;lewisite;Mechlorethamine;Metabolic;Metabolism;Methods;Modeling;Monitor;mouse model;Mus;Mustard;Mustard Compounds;Mustard Gas;Nature;Nitric Oxide;Nitrogen;novel therapeutic intervention;novel therapeutics;Nuclear;Oxidants;oxidative damage;Oxidative Stress;Oxides;Oxygen;Pathogenesis;Pathogenicity;Peroxonitrite;Phase;Publishing;Reactive Nitrogen Species;Reactive Oxygen Species;Research;response;Role;single-cell RNA sequencing;Skin;skin damage;Skin injury;Skin repair;Structure;Sulfides;Superoxide Dismutase;Technology;Terrorism;Testing;Time;tool;Toxic effect;Transplantation;Vesicants;Work;wound healing

PROJECT_TITLE: The Initiation of Vesicant Skin Injury at a Single Cell Level


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Narrative This project investigates how the gut microbiota communicates with the bone marrow to alter gut inflammation and protect from infection with enteric pathogens. Understanding the mechanisms of this process will inform future studies in the development of treatments for both infectious and inflammatory diseases.

PI_NAMEs: BURGESS, STACEY L (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Adoptive Transfer;Amebiasis;Amebic colitis;Amoeba genus;Antigens;Antiparasitic Agents;Bacteria;Bile Acids;bile salts;Bioinformatics;Biological Assay;Biology;Bone Marrow;Chemicals;Child;Cholates;chromatin immunoprecipitation;Clostridium;Colitis;Communicable Diseases;Communication;Data;Dedications;dehydroxylation;deoxycholate;Deoxycholic Acid;Development;Diarrhea;Disease;Educational process of instructing;Entamoeba;Entamoeba histolytica;enteric pathogen;Epigenetic Process;Exposure to;Future;Gene Expression;granulocyte;granulocyte-monocyte progenitors;Granulopoiesis;gut colonization;gut inflammation;gut microbiome;gut microbiota;Hematopoiesis;host microbiota;Immune system;Immunity;Immunologic Memory;In Vitro;Infant;Infection;Infectious colitis;Inflammation;Inflammatory;innovation;Intestines;Knockout Mice;Letters;low income country;Marrow;Measures;Mediating;Mediator;Metabolic;microbial;microbiome;microbiome research;microbiota;Modeling;Monoclonal Antibodies;monocyte;Mucous Membrane;Mus;Natural Immunity;neutrophil;next generation;next generation sequencing;novel;novel strategies;pathogen;Pathogenesis;Pathway interactions;Phenotype;Population;Predisposition;prevent;Process;Production;professional atmosphere;progenitor;receptor;Research;response;Serum;Severities;Signal Transduction;stem cell expansion;stem cell population;Testing;therapy development;trafficking;Training;transcriptome sequencing;translational medicine;Vaccines;whole genome;Work

PROJECT_TITLE: Gut microbiome communication with the bone marrow regulates intestinal inflammation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-M(02)M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative RADOR-KY (Rapid Actionable Data for Opioid Response in Kentucky) is a statewide population-based surveillance system with a key feature of forecasting opioid-related overdose mortality and morbidity, so that public health resources can be deployed timely to the areas and populations that need them most to save lives. The system currently integrates 11 sources of data, but these do not include social media. This supplement proposes to investigate the value of two sources of (in principle, real-time) social media data (Reddit, Twitter/X) to improve the performance of forecasting algorithms, potentially providing a model for real-time opioid overdose epidemic surveillance.

PI_NAMEs: SLAVOVA, SVETLA STEFANOVA (contact);TALBERT, JEFFERY C

PROJECT_TERMS: addiction;Address;Administrative Supplement;Affect;Algorithms;Anxiety;Area;Artificial Intelligence;Communities;computerized data processing;Country;County;COVID-19 pandemic;Data;data ingestion;Data Linkages;Data Sources;data streams;Disease;Distress;Emotions;Epidemic;experience;Funding;Future;Grant;Happiness;Health Resources;Healthcare Systems;high risk;Household;Illicit Drugs;improved;Informatics;Information Systems;insight;Intervention;Kentucky;Language;large language model;Link;Machine Learning;machine learning model;Measures;meetings;Mental Depression;Methods;mobile application;model design;Morbidity - disease rate;mortality;mortality statistics;National Institute of Drug Abuse;Natural Language Processing;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Overdose;overdose death;overdose prevention;overdose risk;parent grant;Parents;Performance;Pharmaceutical Preparations;pharmacovigilance;Policies;Population;population based;Predictive Analytics;predictive modeling;Predictive Value;Productivity;psychologic;Public Health;public health priorities;real time model;Recovery;Reporting;Research;Resolution;Resource Allocation;Resources;response;Risk;Signal Transduction;social;social media;Social Values;Source;Statistical Models;surveillance strategy;Surveys;System;Testing;Time;trend;Twitter;United States;Universities;Visual;Visualization software;web app;Work

PROJECT_TITLE: Enhancing opioid surveillance in RADOR-KY using social media


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The research proposed in this application will investigate and target the aberrant TLR4-MyD88 signaling pathways that regulate disease promoting macrophages (immune cells) associated with laryngotracheal stenosis. Secondarily, we will investigate the utility of the S100A8/A9 protein as a predictor for the development of laryngotracheal stenosis in patients who require prolonged endotracheal intubation for critical illness.

PI_NAMEs: MOTZ, KEVIN  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Administrative Supplement;Attenuated;Award;Back;Biological Response Modifiers;biomarker development;candidate marker;career development;CD4 Positive T Lymphocytes;Cells;Critical Illness;Daughter;Development;Development Plans;Disease;Dysphonia;Dyspnea;Fibrosis;genetic regulatory protein;Immune;Immune response;improved;Inflammation;Injury;Intratracheal Intubation;Intubation;Investigation;Larynx;Macrophage;Macrophage Activation;Mediating;Medical;Mentored Patient-Oriented Research Career Development Award;Modeling;Molecular;Mus;operation;Operative Surgical Procedures;Parents;pathogen;Pathogenesis;Pathologic;Patients;Pattern;Phenotype;Population;Productivity;Proteins;receptor;Research;Role;S100A8 gene;Secondary to;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Son;Source;Specialist;Stenosis;Subglottis structure;Time;Tissues;TLR4 gene;Toll-like receptors;Trachea

PROJECT_TITLE: Targeting pathologic macrophage activation through inhibition of MyD88 to attenuate laryngotracheal stenosis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Racial and Ethnic Minority Health Research

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: NeuroTech Harbor (NTH) led by Johns Hopkins and Howard Universities will gather innovators, expert mentors, and resource providers to accelerate the development of highly promising solutions to improve neurological health for all. To address the lack of women and under-represented minority innovators, it will create the nation's first incubator ecosystem with an Equitech philosophy - the belief that diversity of teams, leadership, and perspectives is a force multiplier to fuel innovation producing solutions accessible to all communities.

PI_NAMEs: ETIENNE-CUMMINGS, RALPH ;MANAYE, KEBRETEN F;NWULIA, EVARISTUS A;SARMA, SRIDEVI V. (contact);THAKOR, NITISH VYOMESH;YAZDI, YOUSEPH

PROGRAM_OFFICER_NAME: WOLFSON, MICHAEL

PROJECT_TITLE: NeuroTech Harbor: Our nation's first equitech ecosystem for neuromedical technologies


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Project Narrative Pediatric acquired aplastic anemia is a life-threatening condition with frequently unknown origin caused by autoreactive T cell destruction of hematopoietic stem cells and inability to produce red blood cells, white blood cells and platelets. Treatment for aplastic anemia can be with immune suppression therapy or intensified with upfront bone marrow transplant. This proposal aims to provide algorithms to identify pediatric patients with newly diagnosed aplastic anemia that will respond favorably to IST, thereby improving cures while minimizing toxicity for this potentially fatal disease.

PI_NAMEs: OVED, JOSEPH H (contact)

PROGRAM_OFFICER_NAME: XU, LEI

PROJECT_TITLE: Phase 2a/2b Study Emapalumab: A Window of Opportunity in Pediatric Aplastic Anemia


PHR: Project Narrative The long term-goal of the proposed study is to develop effective strategies to ensure that cancer survivors have access to guideline concordant care and timely referrals to supportive services at Stanford Medicine. The project will evaluate Stanford’s alignment with recently issued National Standards for Cancer Survivorship Care, identify gaps and barriers to effective care delivery, and provide data and insights to inform survivorship care implementation, resource allocation, and training of professionals to deliver quality survivorship care.

PI_NAMEs: ARTANDI, STEVEN E (contact)

PROJECT_TERMS: Address;Administrator;Advocacy;Aftercare;Area;barrier to care;Basic Science;Biomedical Engineering;Biometry;California;cancer care;Cancer Center;Cancer Etiology;Cancer Patient;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer therapy;Cardiology;care delivery;care systems;Caring;Catchment Area;Cities;clinical care;Clinical Research;Collaborations;Communities;community partners;community setting;Complex;Comprehensive Cancer Center;Computerized Medical Record;County;Data;Data Analyses;Data Collection;data integration;Dermatology;design;Detection;Diagnosis;Dietitian;Disease;Early Diagnosis;Early treatment;Education;Effectiveness;Emotional;Ensure;Equity;Evaluation;Face;Fostering;Future;Goals;Guidelines;Gynecology;Health;Health Personnel;Health Professional;health record;Health system;Healthcare;Healthcare Systems;improved;Incidence;informant;innovation;insight;Institution;Institutional Policy;interest;Intervention;Interview;Life;Malignant Neoplasms;Medical Care Team;Medical Records;medical specialties;Medicine;Mental Health;Methods;Mission;Modeling;Nephrology;Oncologist;Outcome;Patient Care;Patients;Personal Satisfaction;Persons;physical therapist;Policies;Population Heterogeneity;Population Sciences;Prevention;Preventive care;Primary Care Physician;Problem Solving;Process;Professional Organizations;programs;Qualitative Research;Recommendation;Recurrence;Redwood;Registries;Reporting;Research;Research Methodology;Resource Allocation;Resources;response;Rheumatology;Role;Salinas Valley;Second Primary Cancers;Service delivery model;Services;side effect;Site;Social Workers;Standardization;Structure;Surveys;Survivors;survivorship;technology development;Testing;tool;Training;Translations;tumor registry;United States;Universities;Work

PROJECT_TITLE: Stanford Cancer Institute


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE This project aims to utilize group model building with clinicians, patients, and families to develop the first qualitative model of childhood cancer survivorship care. The model will identify and analyze barriers within the care process to improve accessibility and adherence to guidelines in non-specialized clinics. The outcomes will identify optimal targets for improving survivorship care, thereby enhancing health equity and improving care delivery for the growing survivor population.

PI_NAMEs: ROBERTS, CHARLES  (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Administrative Supplement;Cancer Center;Cancer Control;Cancer Family;Cancer Patient;Cancer Survivorship;cancer survivorship care;cancer type;Cardiomyopathies;care delivery;care systems;Caring;Chest;Child Care;childhood cancer survivor;Chronic;Clinic;Clinical;Clinical Practice Guideline;Collaborations;Communities;Community Practice;community setting;Complex;Comprehensive Cancer Center;design;Development;dynamic system;Educational workshop;Ensure;Equity;evidence base;experience;Face;Family;Feedback;Focus Groups;follow-up;Future;Genetic Predisposition to Disease;Geography;Goals;Guidelines;Health;health care delivery;health equity;Health Personnel;health related quality of life;Health Sciences;Healthcare Systems;Home;improved;Individual;innovation;insight;interdisciplinary approach;interest;Intervention;Interview;Knowledge;lens;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical;medical vulnerability;Methods;Mission;model building;Modeling;Morbidity - disease rate;multidisciplinary;multiple chronic conditions;Multiple Partners;novel;Oncology;Outcome;Participant;Pathway interactions;Patients;Population;Preventive service;Primary Care;primary care provider;Procedures;Process;process optimization;programs;Provider;psychosocial;Quality of Care;Quality of life;Radiation;Recommendation;Recording of previous events;recruit;Research;Resources;response;Risk Factors;Saint Jude Children's Research Hospital;Science;Series;Site;Survivors;survivorship;System;treatment risk;treatment services;Uncertainty;Vulnerable Populations;Work

PROJECT_TITLE: P30 Administrative Supplement for Assessing and Enhancing Survivorship Care


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Child malnutrition has numerous devastating consequences, including impaired synthesis of bile acids (BAs), which help absorb dietary nutrients and regulate metabolism. The goal of this proposal is to understand how malnutrition suppresses BA synthesis. Results from these studies will help us develop new therapies to restore BA levels, improve outcomes of therapeutic feeding to treat malnutrition, and increase survival among children suffering from malnutrition.

PI_NAMEs: PREIDIS, GEOFFREY A (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Adipocytes;Adipose tissue;Albumins;Amino Acids;Anabolism;Anesthesia procedures;Attention;Award;Bile Acid Biosynthesis Pathway;Bile Acids;Biogenesis;Biological Assay;Blood Coagulation Disorders;Blood Coagulation Factor;Butyrates;career;career development;Carnitine Palmitoyltransferase I;Cell Culture Techniques;Cell Fraction;Cell Fractionation;Cell Line;Cells;Centrifugation;Cessation of life;Child;Child Malnutrition;Child Mortality;Citric Acid Cycle;cofactor;collagenase;Complement;Control Groups;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;CYP7A1 gene;Cytosol;Data;Defect;density;Dependovirus;Development Plans;Diet;dietary;Dietary Proteins;Digestion;Dose;Endoplasmic Reticulum;Enzymes;Esterified Fatty Acids;Exhibits;expectation;experience;experimental study;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;Female;Foundations;Freezing;Functional disorder;Funding;Genes;Glucose;Goals;Growth;Harvest;Heme;heme biosynthesis;Hepatic;Hepatocyte;Homeostasis;Hour;Impairment;improved outcome;In Vitro;insight;Integral Membrane Protein;interest;Label;Laboratories;Learning;Link;Lipase;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Liver;Liver Dysfunction;male;Malnutrition;Measures;Mediating;Membrane;Metabolic;Metabolism;microbial;Mitochondria;Modeling;mouse model;Mus;non-alcoholic fatty liver disease;novel;novel therapeutics;Nuclear Receptors;Nutrient;nutrient absorption;Nutritional;Oils;Operative Surgical Procedures;Organelles;Outcome;oxidation;Pathway interactions;Perfusion;perilipin;Phospholipase;Phosphorylation;Physiological;postnatal;Process;Production;protein expression;Protein Kinase A Inhibitor;Protein-Restricted Diet;Proteins;Protocols documentation;Publishing;receptor;Receptor Activation;Reporting;Research;response;Role;Sampling;screening;Signal Transduction;Small Interfering RNA;Sodium;Sodium Chloride;Sterility;sterol esterase;Stimulus;Sucrose;Surface;System;Techniques;Testing;Therapeutic;therapy outcome;Tissue Culture Techniques;tool;Training;Western Blotting

PROJECT_TITLE: The metabolic basis for impaired bile acid synthesis in malnutrition


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Complementary and Integrative Health;Genetics;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE  Neuropathic pain is a serious and long-term neurotoxic side effect of chemotherapy affecting more than 68% of cancer patients, and is currently without treatment. Our studies on sensory neuronal maintenance have found NMNAT proteins to be among the most robust and versatile neuroprotective factors known and have the potential to mitigate sensory dysfunction. The proposed studies will discover ways to enhance sensory neurons' self-protection abilities by efficiently regulating NMNAT expression via microRNA and neutral compounds, thus aid in the design of therapeutic treatments for neuropathic pain.

PI_NAMEs: ZHAI, RONG GRACE (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Affect;Afferent Neurons;Behavior;Bioinformatics;bioinformatics tool;Biological Models;Cancer Patient;candidate identification;candidate selection;Cell Culture Techniques;chemotherapy;Chemotherapy-induced peripheral neuropathy;chronic neuropathic pain;chronic pain;Computers;Data Science;design;Development;Dietary Supplementation;Dose;Dose Limiting;Drosophila genus;Drosophila inturned protein;effective therapy;efficacy evaluation;Enhancers;Environment;Enzymes;Equilibrium;Essential Genes;experience;experimental study;Functional disorder;Genetic;Genetic Models;Genetic Transcription;Glutamate-ammonia-ligase adenylyltransferase;Goals;high throughput screening;Homeostasis;Hypersensitivity;in vivo;in vivo Model;innovation;Larva;Maintenance;Mammals;Mediating;Messenger RNA;Metabolism;MicroRNAs;Modeling;Molecular;Morphology;mRNA Precursor;mRNA Stability;Natural Compound;Neurons;Neuropathy;neuroprotection;neurotoxic;Nicotinamide Mononucleotide;Nociception;novel therapeutics;opioid use;Outcome;Paclitaxel;Pain;painful neuropathy;Pathway interactions;Patients;Peripheral;Peripheral Nervous System Diseases;pharmacologic;Pharmacology;Phase;Population;Prevention;Protein Isoforms;Proteins;proteostasis;recreational drug use;Regulation;Reporter;Research;resilience;Resort;RNA;RNA Splicing;Role;Sensory;side effect;Site;symptom treatment;Symptoms;System;Therapeutic;Therapeutic Agents;Tissues;tool;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: microRNA regulation of NMNAT-mediated Neuroprotection against Peripheral Neuropathy and Chronic Pain


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

PHR: Project Narrative: The proposed project examines the extent to which the Buffet Cancer Center Survivorship Program aligns with recently developed National Standards for Survivorship Care by evaluating the organizational policies and processes for delivering survivorship care. Document reviews and interviews will be conducted to assess the alignment of current policies and procedures with the National Standards, as well as EHR analyses to determine survivorship program utilization and examine referral rates and the number of survivors lost to follow-up across cancer types. Using the National Standards for Survivorship Care as a guiding framework, this study seeks to inform policy, practice, and future research efforts aimed at improving the long- term care and outcomes of cancer survivors in the United States.

PI_NAMEs: SWEASY, JOANN B. (contact)

PROJECT_TERMS: Address;Administrative Supplement;Administrator;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;Cancer Patient;Cancer Survivor;cancer survivorship care;cancer type;care delivery;Caring;Catchment Area;Characteristics;Clinical;Collaborations;demographics;Development;Diagnosis;Disparity;Effectiveness;Electronic Health Record;Ensure;Evaluation;follow-up;Frequencies;Glean;Grant;Health;Health Personnel;Healthcare Systems;improved;improved outcome;innovation;insight;Institutional Policy;integrated care;interest;Interview;Long-Term Care;Measures;medical specialties;Methods;Modality;Modeling;National Cancer Institute;Nebraska;Organizational Policy;Outcome;parent grant;Parents;Pathway interactions;patient navigation;patient oriented;Patient Outcomes Assessments;Patients;Personal Satisfaction;Policies;Procedures;Process;programs;Provider;Publications;Publishing;Quality of Care;Recommendation;Research;Resources;response;rurality;Services;social;sociodemographic factors;Stage at Diagnosis;Support Groups;Survivors;survivorship;Training and Education;translational cancer research;United States;United States Department of Veterans Affairs;Variant;Visit

PROJECT_TITLE: Applying National Standards to Evaluate Cancer Survivorship Care Quality: A Mixed Methods Study

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE This project is relevant to public health by identifying opportunities to tailor cancer survivorship care programs' policies, processes, and evaluation/assessment metrics to meet the needs of patients with head and neck cancer living in urban and rural settings. Thus, this project aligns with the National Cancer Institute's mission by advancing scientific knowledge in cancer survivorship and helping all people live longer, healthier lives.

PI_NAMEs: VAN CLEAVE, JANET H (contact)

PROGRAM_OFFICER_NAME: D'ANGELO, HEATHER

PROJECT_TERMS: Address;Administrator;Adverse event;Aftercare;aggressive therapy;cancer care;Cancer Science;Cancer Survivor;Cancer Survivorship;cancer survivorship care;care delivery;Caring;Cessation of life;chemotherapy;Clinic;Combined Modality Therapy;cost;County;Data;Deglutition Disorders;Development;Diagnosis;digital;Disparity;Effectiveness;Electronic Health Record;electronic health record system;Electronics;Evaluation;evidence base;experience;Future;Head and Neck Cancer;Health Sciences;Health system;Healthcare Systems;Hospitalization;Human;Immobilization;Immunotherapy;implementation strategy;improved;interest;Intervention;Interview;Knowledge;Lead;Location;Mission;Monitor;Multi-Institutional Clinical Trial;multidisciplinary;National Cancer Institute;Neck;nutrition;Operative Surgical Procedures;Outcome;pain symptom;Parents;Patient Care;Patients;Persons;Policies;Population;Population Heterogeneity;premature;prevent;Process;programs;Provider;Public Health;Qualitative Research;Quality of Care;Quality of life;quality of life for cancer survivors;Radiation therapy;Rehabilitation therapy;Reporting;Research;response;Rural;rural area;rural patients;Rural Population;rural setting;Scientific Advances and Accomplishments;Services;Site;Support Groups;Surveys;Survival Rate;Survivors;survivorship;Symptom Burden;Symptoms;System;Texas;theories;Time;United States;Universities;urban area;Urban Population;urban setting;Visit;Work

PROJECT_TITLE: Assessing and Enhancing Survivorship Care In Rural and Urban Patients with Head and Neck Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)-S]


ORG_CITY: ARLINGTON

PHR: PROJECT NARRATIVE The National Association of State Departments of Agriculture (NASDA) project entitled A Coordinated National Approach to Supporting, Promoting, and Implementing FDA's Produce Safety Rule and the Produce Regulatory Program Standards will continue building on three important objectives established under previous cooperative agreements:   Supporting the efforts of federal, state, and territorial government agencies in building a  Produce Safety Integrated Food Safety System;   Supporting and expanding established systems for sharing, promoting, and collaborating  on best practices, operating documents, procedures, and other tools to foster a consistent  national produce safety program; and   Supporting the maintenance and advancement of the Produce Regulatory Program  Standards (PRPS). These three objectives will support FDA's goal of developing, implementing, and improving a nationally consistent support system which facilitates the implementation of state and territorial produce safety regulatory programs that are modernized and aligned with the standards set forth in the FDA's rule: Standards for the Growing, Harvesting, Packing, and Holding of Produce for Human Consumption (commonly referred to as the Produce Safety Rule).

PI_NAMEs: REARDON, JOE  (contact)

PROGRAM_OFFICER_NAME: HEAD, DANIELLE

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-T (08)]


ORG_CITY: SOMERSET

ORG_NAME: TARGETED THERAPY TECHNOLOGIES, LLC

ORG_STATE: NJ

PHR: Project Narrative: This application requests funds to support the efforts of Targeted Therapy Technologies, LLC (3T) to build on the strong preliminary results of Episcleral Topotecan (Chemoplaque) Phase I studies treating eyes with refractory retinoblastoma, indicating 89% sustained Complete Response (all CRs out > 2 years) with the RP2D (1.2 mg) with the only toxicity being ocular inflammation (scleritis) that resolves after removal. Further, there was no systemic toxicity or detectable exposure in blood. In the refractory setting, as a single treatment (no cycles or multiple treatments) the Chemoplaque treated refractory solid tumor, vitreous and subretinal seeds. We are unaware of other interventions that can robustly treat all three lesions—let alone as a single treatment in a refractory setting. We propose a Phase I-II study to expand toxicity and effectiveness data of Episcleral Topotecan (Chemoplaque). In this study, EUAs will be at 0, 4, 8, and 12 weeks (see protocol in appendix) reducing the frequency to standard of care as efficacy and safety have been established. Assessment of retinoblastoma tumor burden is problematic. Unlike other cancers, both eyes of the child may have multiple tumors, with multiple primary treatment options and multiple subsequent treatments, challenging the difficulties of Response Evaluation Criteria In Solid Tumors (RECIST).1 Rather than tumor size, retinoblastoma cancer activity is best evaluated by experts using many tools. We built for the first Topotecan Chemoplaque study, the SWIMMERRB display of all therapies to a study eye before and after the Topotecan Chemoplaque intervention, which visually shows Progression-free Survival and details the multiple treatments before the intervention and after for recurrences. We consider any cancer therapy to the study eye after removal of Topotecan Chemoplaque to be evidence of recurrence. Through consensus building conferences primarily with patients and those with lived experience in retinoblastoma, we will seek numerical values to represent invasiveness/lifelong impact of each therapy. Application of the values to the various Topotecan Chemoplaque study long term outcomes, may validate the SWIMMERRB as a unique RECIST tool1. Such a SWIMMERRB tool may enable retinoblastoma clinical trials to have a standardized, validated output and assist families in treatment choices. The Chemoplaque in refractory settings required single (one) placement with sustained 6-week treatment (without need for multiple cycles or multiple treatments) treating refractory solid tumor, subretinal, and vitreous seeds with potential to significantly reduce patient burden in this micro-orphan childhood retinoblastoma cancer. With its simple placement and absence of any systemic toxicity (or detectable exposure in blood), this may be especially relevant in developing countries. 1. Berry JL, Munier FL, Gallie BL, et al. Response criteria for intraocular retinoblastoma: RB-RECIST. Pediatr  Blood Cancer. May 2021;68(5):e28964. doi:10.1002/pbc.28964 Project Narrat

PI_NAMEs: CARVALHO, RICARDO A (contact)

PROJECT_TITLE: Retinoblastoma Phase II Expanded Access Clinical Trial


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Hematology;Rare Diseases

ORG_CITY: MONROVIA

ORG_NAME: CHROMOLOGIC, LLC

PI_NAMEs: NGUYEN, THERESA  (contact)

PROJECT_TERMS: biodosimetry;Blinded;Cancer Center;circulating microRNA;Cities;Clinic;Clinical;Contractor;Development;Devices;Documentation;Evaluation;experience;Fibrosis;Gene Expression;Goals;Head and Neck Cancer;head and neck cancer patient;Laboratories;Late Effects;Malignant Neoplasms;Marketing;medical countermeasure;meetings;microRNA biomarkers;MicroRNAs;Neutropenia;Nuclear;Oncology;Patients;Phase;predictive test;Radiation;Radiation Fibrosis;Radiation Injuries;recruit;sample collection;Sampling;Sarcoma;Sensitivity and Specificity;Testing;Translating;Universities;Validation

PROJECT_TITLE: Development of Radiation/Nuclear Medical Countermeasures (MCMs) and Biodosimetry Devices


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PI_NAMEs: ATRIO, JESSICA  (contact)

PROJECT_TERMS: Clinical;Clinical Trials Network;Communication;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Contractor;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;Performance;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;Time;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - ALBERT EINSTEIN


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Haifa

ORG_COUNTRY: ISRAEL

ORG_FIPS: IS

ORG_NAME: PLURISTEM, LTD

PI_NAMEs: FRANCO-YEHUDA, CHEN  (contact)

PROJECT_TERMS: Animal Model;animal rule;B-Lymphocytes;Biological Assay;Biotechnology;C57BL/6 Mouse;Cell Therapy;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Contractor;Controlled Study;cytokine;design;Development;Dose;efficacy evaluation;efficacy study;Failure;Future;Goals;Hematopoietic;Hour;Human;In Vitro;in vivo;Licensure;manufacture;migration;novel;Patients;Placenta;Prevention;Production;Radiation;Radiation exposure;Radiation Toxicity;Radiobiology;Research Institute;response;Rodent;Sampling;single cell analysis;Stromal Cells;transcriptome sequencing;Treatment Protocols;Whole-Body Irradiation

PROJECT_TITLE: DEVELOPMENT OF PLX-R18 CELL THERAPY AS A COUNTERMEASURE FOR HEMATOPOIETIC ACUTE RADIATION SYNDROME


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy are a leading cause of maternal mortality and morbidity in the United States. The highest prevalence and most severe cases are in Black women, who also have the highest pregnancy-related mortality at 41/100,000 compared to 16.7/ 100,000 births in the general population. This study will examine whether the association between maternal race/ethnicity and hypertensive disorders of pregnancy is partially mediated by psychosocial stress in pregnancy, contributing to the knowledge of preventable causes of hypertensive disorders of pregnancy and informing the development of interventions by elucidating possible causal pathways to reduce racial/ethnic pregnancy health disparities.

PI_NAMEs: CLEMONS, AUTUMN M (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Adolescent;Affect;age group;allostatic load;Amalgam;Attenuated;Biological;Birth;Black race;black women;case control;Child;Child Health;cohort;coping mechanism;critical period;Data;depressive symptoms;design;Discipline of obstetrics;Discrimination;Disparity;Economics;Educational Status;Employment;Environment;ethnic difference;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;Face;Fetus;General Population;Genetic;Health;health care availability;health disparity;health inequalities;High Prevalence;Human Development;Hypertension;improved;Income;Individual;Institutionalization;Knowledge;Life course epidemiology;Life Cycle Stages;Literature;Lived experience;Maternal Health;maternal morbidity;Maternal Mortality;Measures;Mediating;Mediation;Mediator;Mission;Modeling;mortality;Mothers;National Institute of Child Health and Human Development;Nulliparity;Outcome;Pathway interactions;Patient Self-Report;perceived stress;perinatal health;Persons;Physiological;Politics;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy health;pregnancy hypertension;Pregnancy Rate;pregnancy related death;pregnant;Prejudice;Proxy;psychosocial;Psychosocial Stress;Public Health;Race;racial difference;racial disparity;racial diversity;racial population;racism;Reporting;Reproductive Health;Risk;social;social culture;social stigma;Social support;stem;Stress;therapy development;Time;United States;White Women;Woman

PROJECT_TITLE: Does self-reported psychosocial stress in pregnancy mediate the association between maternal race/ethnicity and hypertensive disorders of pregnancy?

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-L(20)L]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Data Science;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: AGA KHAN UNIVERSITY (KENYA)

PHR: NARRATIVE To overcome existing barriers to histopathology services critical for cancer care in Africa, this project aims to leverage an existing artificial intelligence (AI)/machine learning-based computational pipeline to develop and validate image analysis algorithms for colorectal cancer (CRC) diagnosis and prognosis in an existing Kenyan cohort. This project will lay the groundwork for an AI-enabled decision support tool for pathologists, or other clinicians involved in cancer care (i.e., radiation oncologist, oncologist), to facilitate prompt and accurate diagnosis, prognosis, risk stratification, and thus therapeutic selection for CRC. Because the computational pipeline leverages open-source software and can be implemented as a turn-key solution intended for web- based cloud deployment, it is well-suited for clinical delivery, capacity building and integration into educational programs, and for future expansion to other emergent or prevalent cancers (i.e., breast, cervical, prostate) in Africa as part of the DS-I Africa Consortium.

PI_NAMEs: BALIS, ULYSSES GREGORY JOHN;RAO, ARVIND ;SALEH, MANSOOR N (contact);SAYED, SHAHIN ;WALJEE, AKBAR K

PROGRAM_OFFICER_NAME: PEARLMAN, PAUL C

PROJECT_TERMS: accurate diagnosis;Address;Adjuvant;Africa;African;Algorithmic Analysis;Algorithms;Architecture;Area;Artificial Intelligence;Biological;Breast;cancer care;Cancer Detection;cancer diagnosis;Cancer Etiology;Cancer Prognosis;Cells;Cellular Morphology;Cervical;Cessation of life;Classification;Clinical;clinical care;clinically relevant;cohort;Collaborations;Colorectal Cancer;Communities;computational pipelines;Computer software;Computer Vision Systems;Computers;cost;Country;Data;Data Science;deep learning;Diagnosis;Diagnostic;diagnostic algorithm;digital;digital imaging;Disease;E-learning;Early Diagnosis;Education;Eye;Funding;Future;Goals;Hematoxylin and Eosin Staining Method;Histologic;Histology;Histopathology;Hospitals;Human;Image;Image Analysis;imaging Segmentation;Incidence;Income;Individual;Infrastructure;innovation;Intervention;Kenya;Machine Learning;machine learning method;machine vision;Malignant Neoplasms;Measurement;Methods;Michigan;morphological criteria;mortality;Oncologist;Online Systems;open source;Outcome;Pathologist;Pathology;Pattern;Performance;Population;Prognosis;prognostic;prognostication;programs;Prostate;Public Hospitals;Radiation Oncologist;Reagent;Recommendation;Reproducibility;Research;Research Project Grants;Resources;Retrospective cohort;Risk Assessment;risk stratification;routine imaging;Rural;screening;Services;Site;Slide;Stains;supervised learning;support tools;Surgeon;survivorship;System;Techniques;Technology;tertiary care;Texture;Therapeutic;Tissue Sample;tool;Training;Treatment Effectiveness;treatment planning;tumor;Universities;University Hospitals;unsupervised learning;vector;Work

PROJECT_TITLE: Leveraging artificial intelligence/machine learning-based technology to overcome specialized training and technology barriers for the diagnosis and prognostication of colorectal cancer in Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: The Houston Health Services Research & Development (HSR&D) Center for Innovations in Quality, Effectiveness and Safety (IQuESt) has been continuously funded by HSR&D since 1990, providing strong scientific leadership and institutional infrastructure dedicated to a model of embedded health system research. We have a nearly 20-year tradition of conducting research in partnership with the health care delivery system and responding to its needs, making us pioneers in the execution of the learning health care system model in VHA. The IQuESt mission, “Improving health and well-being through innovations in health care delivery”, conveys our commitment to transformative and innovative research that is aligned with VHA national priorities. IQuESt is ideally poised to contribute to making care more accessible, safer, and more patient-centered with innovative research, rapid implementation of evidence, novel methodologies, solid partnerships, stakeholder engagement, career development of scientists, and infrastructure to promote the learning health care system in VHA.

PI_NAMEs: PETERSEN, LAURA A (contact)

PROJECT_TERMS: Biological Models;career development;Caring;Dedications;Effectiveness;Funding;Health;health care delivery;Health Services Research;Health system;Healthcare Systems;improved;Infrastructure;innovation;Institution;Leadership;Learning;Methodology;Mission;Modeling;novel;patient oriented;Personal Satisfaction;Research;research and development;Safety;Scientist;Solid;System;systems research

PROJECT_TITLE: Center for Innovations in Quality, Effectiveness, and Safety (IQuESt)


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Not applicable.

PI_NAMEs: DOBSCHA, STEVEN K (contact)

PROJECT_TERMS: Area;career development;Caring;Collaborations;Decision Making;Dissemination and Implementation;empowerment;Ensure;experience;Faculty;falls;Family;Feedback;Fellowship;Goals;Health;Health Services Research;Healthcare;Healthcare Systems;improved;innovation;Malignant neoplasm of lung;member;Mental Health;Methodology;Mission;non-opioid analgesic;operation;Opioid;Oregon;Pain;Pain management;Patient-Centered Care;Personal Satisfaction;prescription opioid;Process;Research;Research Methodology;Research Personnel;Safety;Science;Self Care;Site;Substance Use Disorder;Suicide prevention;Support System;Technology;Universities;Veterans;whole health

PROJECT_TITLE: Center to Improve Veteran Involvement in Care (CIVIC)


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: The Center of Innovation for Complex Chronic Healthcare (CINCCH) is a HSR&D COIN based at Hines VA Hospital. CINCCH's mission is to conduct research to optimize coordination and contextualization of healthcare delivery and improve outcomes for Veterans with high priority neurologic conditions, disseminate and implement best evidence, and train future researchers. We utilize innovative direct observation methods to collect data that compliments other forms of data to assess quality and patient experiences. CINCCH collaborates with several VA Operations Partners and is affiliated with three universities in the Chicago area. In addition, we have established a Veterans Engagement Panel that provides feedback on grant proposals and dissemination activities. Our COIN's vision is to create the evidence and implement the findings to support and guide VA in providing the best care in the right place at the right time.

PI_NAMEs: WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Address;Antibiotics;Applications Grants;Appointment;Area;Award;bone health;Books;care coordination;career;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic;Chronic Care;Collaborations;Complex;Data;decubitus ulcer;Disease;Doctor of Medicine;Doctor of Philosophy;experience;Faculty;Feedback;Funding;Future;health care delivery;Health Care Research;Health Services;Healthcare;Homelessness;Homogeneously Staining Region;Hospitals;Illinois;improved;improved outcome;innovation;Institution;instrument;Kidney Diseases;Leadership;Life;Medicare;Mentors;Methods;Mission;Modeling;Modernization;Neurologic;operation;Paper;Patient-Centered Care;Patients;Persons;pharmacy benefit;Physical Medicine;Physical Rehabilitation;programs;Renal dialysis;Research;Research Personnel;Respiratory Tract Infections;Scientist;Services;Source;Spinal cord injury;telehealth;Time;Training;Universities;Veterans;Vision;Weight Gain;Weight maintenance regimen;Work


ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: The Center of Innovation (COIN) for Veteran-Centered and Value-Driven Care has had outstanding productivity and impact on Veteran healthcare and well-being through the application of the National Academy of Medicine's learning health system. In the past 3 years, our 47 investigators generated ~$47 million in operating revenue, published 583 manuscripts, and led 113 projects across our research, implementation science, operational projects/program evaluations and training programs. Our dual-site Center will continue to address our two focus areas: 1) promote Veteran-centered care to improve patient experiences across VA healthcare and community settings and 2) advanced value-driven care by providing Veterans the highest quality care at the lowest financial burden. Building on our prior success, we will continue to partner with operational leaders and our Veteran Engagement Board to innovate new research, implementation science, and operational programs as well as train the next generation of outstanding research leaders.

PI_NAMEs: AU, DAVID H (contact);HO, P. MICHAEL

PROJECT_TERMS: Academy;Address;Area;Award;care delivery;career development;Caring;clinical care;Colorado;Communities;community setting;Complex;Congresses;Deimplementation;disparity elimination;Evaluation;experience;Faculty;Financial Hardship;Funding;geographic disparity;health care service;health care settings;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Healthcare Systems;implementation science;improved;improved outcome;innovation;Intervention;Knowledge;Lead;Learning;Manuscripts;Medical center;medical specialties;Medicine;Mental Health Services;Methods;Mission;next generation;novel strategies;Paper;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;Policies;Postdoctoral Fellow;Primary Care;primary health service;Productivity;Program Evaluation;programs;Provider;Psyche structure;Publishing;Quality of Care;Research;research clinical testing;Research Personnel;Rural Health;Safety;satisfaction;Self Management;Site;socioeconomic disparity;sound;Statutes and Laws;success;Suicide prevention;Training;Training Programs;Translating;United States National Institutes of Health;Universities;Veterans;Washington;Women's Health;Work;Workforce Development

PROJECT_TITLE: Seattle-Denver Center of Innovation for Veteran-Centered and Value-Driven Care


ORG_CITY: WEST HAVEN

ORG_NAME: VA CONNECTICUT HEALTHCARE SYSTEM

ORG_STATE: CT

PHR: This application proposes the continuation of a Center of Innovation (COIN), called the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center. The COIN builds on the successes of our existing PRIME Center at VA Connecticut Healthcare System. The goals of the PRIME Center are to conduct research to improve care for all Veterans with a specific focus on pain management and women's health. The Center also fosters innovative research in emerging areas like suicide prevention and CHOICE care. Through a Veteran Engagement Group, the Center strives to be Veteran-centric. Investigators provide research mentoring to train the next generation of VA health services researchers. To achieve its goals, the PRIME Center is supported by partnerships with VHA Patient Care Services and Operations leaders, especially the Pain Management Program and Women's Health Services, as well as a large number of cross-COIN and other VHA medical center collaborations.

PI_NAMEs: BASTIAN, LORI A (contact)

PROJECT_TERMS: Area;Award;behavioral health;Behavioral Sciences;care systems;career;career development;Caring;Chronic;Clinical;Collaborations;Complementary Medicine;Connecticut;Disparity;Eating Disorders;Education;Electronic Health Record;Fostering;gender difference;Goals;Health;health data;Health Services;Health Services Research;Healthcare;Healthcare Systems;High Prevalence;implementation research;implementation science;improved;Informatics;Infrastructure;innovation;Institution;Integrative Medicine;Intervention;Leadership;Medical;Medical center;Medical Informatics;medical schools;medical specialties;Mental Health Services;Mentors;Minority;Mission;multimodality;Neurology;New England;next generation;operation;Opioid;Pain;Pain management;Pain Research;Patient Care;Patient-Centered Care;Primary Care;programs;Reproductive Health;Research;Research Methodology;Research Personnel;sex;Strategic Planning;success;Suicide;Suicide prevention;System;Technology;Training;Veterans;Woman;Women's Health;Women's Health Services

PROJECT_TITLE: Pain, Research, Informatics, Multimorbidities, Education