NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Precision Medicine;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  When treatments intended to prevent and treat disease are approved by regulatory bodies, little is known about their potential harms; particularly concerning is the lack of information on the effects of such treatments in many patients who will ultimately receive them (for example, older adults with multiple chronic conditions taking multiple medications). While post-approval real-world evidence can fill this knowledge gap and support optimal treatment decisions, such studies must be designed and analyzed appropriately to avoid bias and erroneous conclusions. Here we propose to develop and evaluate novel methods to increase the validity of nonexperimental studies applying propensity score methods by using data from Medicare beneficiaries linked with a variety of sources including electronic health records and surveys evaluating trends in health and aging.

PI_NAMEs: STURMER, TIL  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;Affect;Aging;beneficiary;Calibration;Caring;Characteristics;Chronic Disease;Classification;Clinical Treatment;clinically relevant;Communicable Diseases;comorbidity;comparative effectiveness;Complex;cost;COVID-19;Data;Data Linkages;Data Sources;Decision Making;design;Development;Diabetes Mellitus;Dimensions;Disease;Drug usage;Educational workshop;Elderly;Electronic Health Record;Enrollment;Epidemiology;Ethics;Event;evidence base;Exclusion;experimental study;Failure;frailty;Funding;Health;Health Surveys;Healthcare;Heterogeneity;improved;Individual;individual patient;innovation;insurance claims;interest;Journals;Knowledge;Link;marginalization;marginalized population;Measures;Medical;Medicare;Methodology;Methods;Modeling;mortality;multiple chronic conditions;novel;older adult;Operative Surgical Procedures;optimal treatments;Oral;patient subsets;Patients;Pattern;Peer Review;Performance;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacotherapy;Phenotype;Play;Polypharmacy;Population;population health;Population Heterogeneity;posters;Prediction of Response to Therapy;preference;prevent;Prevention;Preventive;Probability;Proliferating;Public Health;Publications;Race;Randomized, Controlled Trials;Recording of previous events;Reproducibility;Research;Research Personnel;Role;Sampling;Scoring Method;simulation;Source;Specific qualifier value;Standardization;Subgroup;symposium;Target Populations;Techniques;tool;treatment choice;treatment effect;trend;Vaccination;Work

PROJECT_TITLE: Propensity scores and preventive drug use in the elderly

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE People with an Inborn Error of Immunity live with uncertainly related to the correct diagnosis, their future, and best management for their condition. The purpose of this study is to provide resources to help physicians and patients make critical decisions regarding care. We will build a database of patient health information and use this as a nexus of efforts to improve patient outcomes by serving as a resource for gene-variant-phenotype in Inborn Errors of Immunity.

PI_NAMEs: SULLIVAN, KATHLEEN E (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Autoimmunity;career;Caring;Cell Line;Clinical;clinical decision-making;clinical phenotype;ClinVar;Collection;Committee Members;Communities;Community Outreach;comorbidity;Complex;congenital immunodeficiency;dashboard;Data;Data Aggregation;Data Analytics;Data Collection;data dissemination;data interoperability;data modeling;data registry;data standards;Databases;Decision Making;demographics;Development;Diagnosis;Diagnostic;Disadvantaged;discrete data;dissemination strategy;Education;Evolution;experience;Faculty;Foundations;Funding;Funding Mechanisms;Future;gene discovery;Genes;Genetic;Genetic Databases;Genetic Diseases;genetic information;genetic variant;Genotype;Goals;Hereditary Disease;human disease;immunodeficiency;Immunologist;Immunology;improved;improved outcome;Infection;Inflammation;innovation;Institution;Institutional Review Boards;Knowledge;Laboratories;Literature;Logical Observation Identifiers Names and Codes;Medical center;medical specialties;Mentors;Modernization;Natural History;new technology;Newsletter;next generation;next generation sequencing;Online Mendelian Inheritance In Man;optimal treatments;Outcome;Outcome Study;Outcomes Research;Participant;Patient Care;patient health information;patient registry;Patient-Focused Outcomes;Patients;Persons;Phenotype;phenotypic data;Physicians;Positioning Attribute;programs;Protocols documentation;Publications;Publishing;Quality of life;R24;Rare Diseases;rare genetic disorder;Registries;Research;Research Design;Research Personnel;Resources;Services;Site;skills;Standardization;Structure;success;Surveys;Systematized Nomenclature of Medicine;Time;treatment strategy;United States;Update;Validation;Variant;Vocational Guidance;web site;Work

PROJECT_TITLE: USIDNET: A resource for clinical immunologists


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Gene Therapy;Genetics;Human Genome;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE It is now possible to design and deliver treatments that work for as few as a single patient, i.e., as truly personalized “n-of-1” medicines. This project will examine the individual and societal challenges and the ethical implications posed by this disruptive new technology through the perspectives of socio/geo-demographically diverse stakeholders (i.e., clinician-scientists, bioethicists, social issues experts, and parents) and provide ethical guidance. We will develop a set of recommendations and points to consider that can guide the fair and just implementation of individualized genomic medicine as it evolves.

PI_NAMEs: BUSH, LYNN ;HOLM, INGRID ADELE;YU, TIMOTHY WEI-WEN (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Address;American;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Authorization documentation;Bioethics Consultants;case-based;Catalogs;Child;Complex;Consensus;Consent;cost;design;Development;Disease;Disease Progression;editorial;Eligibility Determination;Equity;ethical, legal, and social implication;Ethics;experience;Family;Foundations;Future;Gene Targeting;gene-targeted therapy;Genetic Diseases;genetic variant;genome editing;Genomic medicine;girls;Goals;Health;Incentives;Individual;individualized medicine;Informed Consent;innovation;Institution;Institutional Review Boards;interest;Intervention;Interview;Investigational Therapies;Investments;Journals;Justice;Malignant Neoplasms;manufacture;Medicine;meetings;Methods;Morbidity - disease rate;mortality;multidisciplinary;Neurodegenerative Disorders;Neurologist;new technology;novel;Nurses;optimism;Outcome;Parents;Pathogenicity;Patient advocacy;Patients;Peer Review;Pharmaceutical Preparations;Policies;Process;Rare Diseases;Recommendation;Reporting;Research Personnel;Resources;Safety;Science;Scientist;Seizures;Sickle Cell Anemia;Site;social;Social Responsibility;sociologist;Source;Spielmeyer-Vogt Disease;Surveys;symposium;targeted treatment;technology platform;Testing;Therapeutic;therapeutic development;therapeutic misconception;Time;underserved community;United States Food and Drug Administration;Work

PROJECT_TITLE: Providing ethical guidance for the development of individualized genomic medicine as rare as n-of-1


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Boulder

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative As the availability of whole-genome sequencing data has grown, so has our appreciation for the role that structural variants (SVs) play in cancers and Mendelian disorders, yet it is still a struggle to determine if an SV observed in a patient is somatic or pathogenic. We propose a new strategy for SV interpretation that dynamically searches tens of thousands of whole genomes to recover any evidence supporting a candidate SV. Searches that return little to no evidence indicate a high-priority variant since SVs that drive cancers and rare diseases should be vanishingly rare in these samples.

PI_NAMEs: LAYER, RYAN M (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Address;Adoption;Algorithms;Benign;Biological Process;cancer genetics;Cancer Patient;Catalogs;Classification;Clinical;clinical application;cohort;Computer Analysis;Computer software;Data;data integration;Data Set;data sharing;Databases;Detection;Diagnostic;Disease;driver mutation;Environment;Frequencies;Funding;Gene Frequency;General Population;Genetic;Genetic Diseases;genetic variant;Genome;genome sequencing;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Human;improved;Label;Level of Evidence;Malignant Neoplasms;Medical Genetics;Mendelian disorder;Methods;Mining;Modeling;National Human Genome Research Institute;Noise;Normal tissue morphology;Other Genetics;Pathogenicity;Patients;Performance;Phenotype;Play;Pollution;Population;Prevalence;Privacy;Publishing;Rare Diseases;Research Personnel;Resource Sharing;Resources;Role;Sampling;search engine;Sequence Alignment;sharing platform;Signal Transduction;Single Nucleotide Polymorphism;Somatic Mutation;statistics;Techniques;Technology;tumor;Tumor Tissue;Variant;variant detection;Visualization;web interface;whole genome

PROJECT_TITLE: Mining Thousands of Genomes to Classify Somatic and Pathogenic Structural Variants

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Facioscapulohumeral Muscular Dystrophy;Genetics;Muscular Dystrophy;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative The progressive muscular dystrophy, facioscapulohumeral muscular dystrophy (FSHD), is a caused by inappropriate expression of the DUX4 gene, but the disease typically does not progress in a smooth fashion, rather in episodes or stages that are thought to be associated with transient bursts of DUX4 expression, because direct evidence of DUX4 protein in muscle specimens has not yet been demonstrated. This project aims to understand whether transient DUX4 expression is sufficient to trigger degenerative processes or to set up a pro- degenerative state that together with injury will lead to a muscle dystrophic phenotype seen in FSHD patients. This research will advance our understanding of the molecular and cellular mechanisms of disease as well as contribute to our understanding of the external factors that participate in FSHD pathology.

PI_NAMEs: BOSNAKOVSKI, DARKO  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Acetylation;Address;Adolescent;Adult;advanced disease;Affect;Animal Model;Animal Muscular Dystrophy;Biological;Biopsy;Cell Compartmentation;Cell Line;Cells;Characteristics;Chromatin;Chromosome 4;Chronic;Clinical Trials;Cytology;D4Z4;defined contribution;Deposition;Development;Disease;Disease Management;Disease Progression;early experience;Embryo;Endothelium;Epigenetic Process;epigenome;experience;experimental study;Extracellular Matrix;Facioscapulohumeral Muscular Dystrophy;Fatty acid glycerol esters;Fiber;Fibrosis;Frequencies;Genes;Genetic;Genetic Diseases;Genetic Transcription;Genome;Grant;Histology;Histone H3;Histones;Homeostasis;Human;In Situ;Individual;infancy;Infiltration;Inflammatory;Inflammatory Infiltrate;Injury;insight;interest;Kinetics;Life;Long-Term Effects;Magnetic Resonance Imaging;middle age;Modeling;Molecular;Mononuclear;mouse model;Mus;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;Muscle function;muscle physiology;Muscular Dystrophies;muscular dystrophy mouse model;muscular structure;Myoblasts;Nature;neuromuscular;Pathologic;Pathology;Patients;Phase;Phenotype;postnatal;prenatal;Process;progenitor;Property;Proteins;Repression;Research;restraint;Role;senescence;Skeletal Muscle;Specimen;System;Testing;transcription factor;Uncertainty

PROJECT_TITLE: To explore the molecular and cellular effects of transient DUX4 expression in skeletal muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative The initiation stage of standard buprenorphine treatment for opioid use disorder (OUD) involves risks of experiencing withdrawal, which acts as a major barrier to treatment uptake for many people with OUD. Microdosing initiation of buprenorphine has emerged as a method to avoid withdrawal, however there have been no clinical trials testing its efficacy in minimizing withdrawal or increasing treatment uptake. In a 4-week randomized controlled trial (RCT), we propose to pilot test a buprenorphine microdosing protocol versus standard treatment initiation at home, investigating efficacy, feasibility, withdrawal, stakeholder experiences, and mediators of initiation success.

PI_NAMEs: HAYES, BENJAMIN T (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Abstinence;Agonist;Anxiety;anxiety symptoms;Area;arm;barrier to care;Buprenorphine;buprenorphine treatment;career;career development;Case Study;Cellular Phone;Clinical;clinical care;Clinical Investigator;Clinical Trials;craving;Data;Death Rate;design;Development;Development Plans;Dose;Dropout;drug testing;Drug user;Ecological momentary assessment;Effectiveness;efficacy testing;Electronics;eligible participant;Enrollment;Event;experience;feasibility trial;Focus Groups;Frequencies;Fright;Future;Goals;Health;Home;Hour;illicit opioid;Impairment;improved;innovation;Intervention;Interview;Investigation;Lesion;Literature;Measures;Mediating;Mediator;Mentors;Mentorship;Methods;mortality;mu opioid receptors;Opioid;Opioid agonist;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Outcome;overdose death;Participant;participant enrollment;Patients;Persons;Pharmacology;Physicians;pilot test;Prevalence;primary outcome;Process;Process Measure;Protocols documentation;Provider;Qualitative Methods;Randomized;Randomized, Controlled Trials;recruit;Relapse;Research;Research Design;Research Personnel;Research Project Grants;Risk;Risk Reduction;Safety;safety and feasibility;secondary outcome;Site;skills;standard care;substance use;success;Symptoms;Technology Assessment;Testing;Therapeutic;Time;Training;treatment as usual;trial design;uptake;Urine;Visit;Withdrawal;Withdrawal Symptom;Writing

PROJECT_TITLE: Microdosing initiation of buprenorphine for people seeking treatment for opioid use disorder

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Despite impressive advancements in treatment, cancer continues to be devastating. Prominent among changes that cause cancer are alterations to metabolic and epigenetic pathways, and there is surprising evidence that these pathways directly communicate to regulate gene expression. Tackling these interconnected pathways for new insights will guide future novel treatments and will benefit patient populations.

PI_NAMEs: BERGER, SHELLEY L (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Area;Biology;Cancer Biology;Cancer cell line;Cancer Etiology;cancer immunotherapy;Cancer Model;Chromatin;Clinic;cofactor;Communication;Development;Disease;DNA;Enhancers;Enzymes;Epigenetic Process;epigenetic regulation;fascinate;Funding Mechanisms;Future;Gene Expression;Gene Targeting;Genes;Genomics;Histones;individual variation;infancy;inhibitor;insight;Link;Malignant Neoplasms;Membrane;Metabolic;Metabolic Pathway;Metabolism;mouse model;multidisciplinary;mutant;Normal Cell;novel;Nuclear;Oncogenes;Oncogenic;Pathway interactions;patient population;patient response;pharmacologic;Production;programs;Proteomics;Publishing;Recording of previous events;refractory cancer;Regulatory Element;Research;Role;small molecule therapeutics;targeted treatment;TP53 gene;transcription factor;tumor;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Interaction between nuclear epigenetic and metabolic pathways in cancer


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Services;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: The proposed undergraduate training program in communication sciences and disorders is relevant to public health, including NIDCD and NIH’s mission to develop a robust biomedical, clinical, and health-services research workforce by increasing its ethnic, racial, and socioeconomical diversity.

PI_NAMEs: GOUPELL, MATTHEW J.;NEWMAN, ROCHELLE S (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Address;American Speech-Language-Hearing Association;Area;Award;Awareness;Basic Science;Biomedical Research;Black, Indigenous, People of Color;career;Career Choice;Clinical Services;Collaborations;college;Communication;Communication impairment;Communities;Data;Development;Development Plans;disability;Disease;Diverse Workforce;Doctor of Philosophy;Education;education research;Engineering;Equity;ethnic minority;Ethnic Origin;evidence base;experience;falls;Fellowship;Financial Support;Freedom;Funding;Funding Opportunities;Future;Goals;hands on research;Health Services Research;Hearing;improved;Individual;innovation;Institution;Knowledge;Laboratories;Laboratory Research;Latinx;Maryland;Mentors;Mentorship;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;next generation;Occupations;peer;peer coaching;Population;Population Heterogeneity;Postdoctoral Fellow;Productivity;programs;Public Health;Publications;Race;racial minority;recruit;Reporting;Research;Research Personnel;Research Support;Research Training;Resources;Science;Scientist;skills;socioeconomic diversity;socioeconomics;Speech;statistics;Structure;student participation;Students;success;symposium;Talents;Time;Training;Training Programs;Translational Research;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: UMD-REACH (Research Equity and Access in Communication and Hearing)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: CINCINNATI

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE This proposal will create breakthrough stability for the blocking-layers used in aptamer-based biosensors, and use that improved stability to: (1) achieve at least 5-day operating longevity for the biosensors; (2) create new fundamental knowledge of biofouling kinetics and other sensor degradation mechanisms. With improved operating longevity, aptamer biosensors are then well-positioned to mirror the historical achievement for 10-14 day continuous glucose meters, but instead applied to new applications such as cardiac health and drug metabolism monitoring.

PI_NAMEs: HEIKENFELD, JASON  (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Achievement;Acute;Adoption;aptamer;bioelectronics;Biosensor;Body Temperature;Cardiac;Cardiac health;Chemistry;Clinical;clinical application;Clinical Research;clinically relevant;Complex;Continuous Glucose Monitor;Data;Defect;density;Dermal;Devices;diabetes management;Diagnostic;Disease Management;Dose;drug metabolism;Electrodes;Electron Transport;Enzymes;fabrication;Fertility;Film;Glucose;glucose monitor;glucose sensor;Gold;Growth;Hour;human disease;improved;in vivo;Industry;insight;Intercellular Fluid;Kinetics;Knowledge;Letters;Longevity;Measures;Modernization;Molecular;Monitor;monolayer;nanomolar;nuclease;operation;Outcome;Oxidation-Reduction;Pharmaceutical Preparations;Positioning Attribute;prevent;Property;real time monitoring;Research;Research Personnel;Resistance;self assembly;sensor;Serum;Signal Transduction;Silanes;success;Sulfhydryl Compounds;Surface;System;Techniques;Technology;Thick;Time;United States National Institutes of Health

PROJECT_TITLE: Breakthrough Blocking-Layer Stability for Broader Clinical Utility of Continuous Aptamer Biosensors


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SYRACUSE

ORG_DEPT: BIOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE  The goal of the proposed research is to elucidate fundamental genetic mechanisms of species diversiﬁcation and to identify molecular pathways that underlie genetic incompatibilities. We will identify basic cellular processes that are impacted by mismatches in genome composition, and thus will identify general mechanisms of genetic defects that can be important in human disease.

PI_NAMEs: AHMED-BRAIMAH, YASIR  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Biological Models;Biology;Cell Physiology;Complex;Coupled;Creativeness;Data;Drosophila genus;F Factor;Functional disorder;Genes;Genetic;Genetic Drift;Genetic Techniques;Genetic Variation;Genome;Genomics;Goals;human disease;Hybrids;improved;innovation;male fertility;Male Sterility;member;Molecular;Molecular Genetics;Mutation;Partner in relationship;Pathway interactions;Population;Process;Proteomics;reproductive;Research;Sterility;Subgroup;tool;trait;transcriptomics;X Chromosome;Y Chromosome

PROJECT_TITLE: The Genomic Basis and Molecular Mechanisms of Speciation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: NEW ORLEANS

ORG_DEPT: PATHOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Nearly 38 million individuals worldwide live with HIV, a chronic viral infection associated with neuroinflammation. Chronic infection and neuroinflammation heighten the risk of neurodegenerative disorders linked to genetic mutations such as those in the Parkinson’s disease gene, LRRK2, which modulates the body’s response to bacterial infection. The proposed research will determine the role LRRK2 plays in the immune response to viral infection and contribute to our understanding of the biological consequences of LRRK2 blockade during early stages of HIV.

PI_NAMEs: VAIL, KRYSTAL  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Address;Agonist;antiretroviral therapy;antiviral immunity;ANXA5 gene;Attenuated;Bacterial Infections;Basal Ganglia;Biological;Biological Assay;Biological Response Modifiers;Biomedical Research;Blood;Bone Marrow;Brain;career;career development;Cell Death;Cells;chemokine;Chronic;Chronic Disease;chronic infection;Clinical;Corpus striatum structure;cytokine;Data;Dedications;Development Plans;Disease;disease model;DNA Sequence Alteration;Encephalitis;Enrollment;Environment;Enzyme-Linked Immunosorbent Assay;Euthanasia;Exhibits;experience;Flow Cytometry;Fresh Tissue;frontal lobe;Future;Gastrointestinal tract structure;Gene Expression;Gene Proteins;Genes;Goals;Grant;Gut Mucosa;Health;Hippocampus;HIV;HIV Infections;HIV-1;Homeostasis;Human;Immune;immune activation;Immune response;Immunity;Immunohistochemistry;immunoregulation;improved;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Infiltrate;inhibitor;Interferon Type I;Intestines;K-Series Research Career Programs;Knowledge;Leukocytes;Life Expectancy;Link;LRRK2 gene;Lymphocyte;Macaca;Macaca mulatta;Macrophage;Mentors;Mentorship;Messenger RNA;Microglia;Mitochondria;mitochondrial metabolism;Modeling;Modernization;Monitor;Morphology;Mucosal Immunity;Mus;Mutate;Mutation;Mycobacterium Infections;Nerve Degeneration;Neurocognitive Deficit;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neurotoxic;nonhuman primate;Outcome;oxidative damage;Parkinson Disease;pathogen;Pathogenesis;pathogenic microbe;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;pharmacologic;Phosphorylation;Phosphotransferases;Play;Poly I-C;Population;Predisposition;Primates;Production;Propidium Diiodide;Proteins;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Resources;response;Rest;Risk;RNA;Role;seroconversion;seropositive;Severities;SIV;tat Protein;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;Training;Tuberculosis;Viral;Viral Load result;Viral Pathogenesis;Virus Diseases;Western Blotting

PROJECT_TITLE: Role of LRRK2 in immunity in a nonhuman primate model of SIV

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative (Relevance) Human suffering due to infectious diseases is widespread, both due to the constant endemic diseases and emerging infectious diseases that can reach epidemic proportions. This program is designed to train biomedical and physician biomedical scientists in the most recent advances in basic and epidemiological sciences, in order to prepare them for productive career in all aspects of Infectious Diseases research.

PI_NAMEs: STAPLETON, JACK T. (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Communicable Diseases;Research Training

PROJECT_TITLE: Research Training in Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative - Public Health Relevance  To speed the development of therapies for inherited or acquired disorders of hearing and balance, we need to better understand the patterns of cellular damage and molecular disorder associated with each different etiology. Because the ear cannot be biopsied, and non-invasive imaging cannot yet provide cellular or molecular level resolution, all of our insights into the pathologies underlying deafness and balance disorders derive from the study of post-mortem specimens of the human temporal bone, which houses the structures of the external, middle and inner ears. This proposal, to join a national network of laboratories devoted to the study of the human temporal bone, seeks to increase the relevant knowledge base by continued accrual and study of new autopsy specimens, distribution of these specimens to other collaborating laboratories, development of new state-of-the-art techniques to extract cellular and molecular information about temporal bone pathology, and train the next generation of researchers and technicians in the art and science of temporal bone study.

PI_NAMEs: LIBERMAN, M. CHARLES;QUESNEL, ALICIA M (contact);SANTOS, FELIPE

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acceleration;Adopted;algorithm development;Archives;Autopsy;Biological;Biopsy;bone;cell injury;Cell Survival;Celloidin;Chemicals;Cochlea;Collaborations;Collection;Complex;Coupling;Data;data de-identification;Databases;deafness;Decalcification;Development;digital;Disease;DNA;DNA Fragmentation;Documentation;Ear;Education and Outreach;Educational Curriculum;Educational process of instructing;Educational workshop;equilibration disorder;Equilibrium;Etiology;ex vivo imaging;Excision;exome sequencing;experience;External Ear;Eye;Fellowship;Fellowship Program;gene therapy;Genetic;genetic analysis;genetic information;Genetic study;Genomics;Hearing problem;Heavy Metals;Hematoxylin and Eosin Staining Method;Hereditary Disease;hereditary hearing loss;Histopathology;Human;Hybrids;Image;Impairment;Improve Access;improved;In Situ Hybridization;Inherited;insight;Institution;Instruction;International;knowledge base;Laboratories;Labyrinth;Lasers;Libraries;Life;light microscopy;Machine Learning;Manuals;Massachusetts;Medical;Medical Records;meetings;Mentors;Methods;Methylmethacrylate;Microtomy;middle ear;Modification;Molecular;Molecular Analysis;Morphology;Muscle;National Institute on Deafness and Other Communication Disorders;new technology;next generation;non-invasive imaging;novel;novel strategies;Online Systems;online tutorial;Osmium;otoconia;outreach;Pathogenicity;Pathologic;Pathology;Pattern;Plastic Embedding;Preparation;preservation;Process;programs;Proteins;Protocols documentation;public health relevance;reconstruction;Recording of previous events;Registries;Research;Research Personnel;Residencies;Resolution;Resources;RNA;sample fixation;Sampling;Scanning;Science;Scientist;searchable database;skills;Slide;software development;Specimen;Speed;Stains;Structure;success;Surveys;symposium;Techniques;Temporal bone structure;therapy development;Three-Dimensional Image;Tissue Donors;Tissue Sample;Tissues;tool;Training;translational study;Underrepresented Minority;United States;Variant;Vestibular Diseases;virtual;web portal;Work;X-Ray Tomography

PROJECT_TITLE: Massachusetts Eye and Ear/ Harvard Initiative for the NIDCD National Human Ear Resource Network


NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Urologic Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The overall goal for our course is to deliver an intensive cutting edge hands-on training workshop on modeling human cancer in the laboratory mouse to a small group of select early career scientists/trainees (graduate students, postdoctoral fellows and new investigators). Participants completing the course will acquire a working knowledge of how to characterize and analyze mouse models of human cancer including brain, breast, lung, colon, prostate and blood. Additionally, the course will cover organoid culture, surgical techniques, imaging, immunology, ectopic and ortotopic xenografting including PDX, necropsy, pathology and histology.

PI_NAMEs: THREADGILL, DAVID W. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: anti-cancer research;Autopsy;Award;Basic Cancer Research;Biomedical Research;biomedical scientist;Blood;Body System;Bone Marrow;Brain;Breast;Cancer Model;career;Characteristics;Collaborations;Collection;Colon;Colon Carcinoma;Communities;Development;Diné Nation;Dissection;Education;Educational workshop;Endoscopy;Environment;Exhibits;experience;Faculty;Faculty Workshop;faculty-student interactions;Fatty acid glycerol esters;Feedback;Gastrointestinal tract structure;Genetic;Genetic Engineering;Genomics;Goals;graduate student;Grant;Histology;Home;human cancer mouse model;human model;Image;Imaging Techniques;Immersion;Immunology;implantation;Infrastructure;Injections;Institution;Instruction;Intubation;Knowledge;knowledge base;Laboratories;laboratory experience;Laboratory mice;Learning;lectures;Lung;lymph nodes;Maine;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;mammary;Medical;meetings;member;Minority Groups;Modernization;Mouse Mammary Tumor Virus;mouse model;Mus;mutant mouse model;NCI Center for Cancer Research;Operative Surgical Procedures;Orchiectomy;Organ;Organoids;Participant;Pathologist;Pathology;peer;Perfusion;Phenotype;Positioning Attribute;Postdoctoral Fellow;Preparation;programs;Prostate;Recording of previous events;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Resources;Schedule;Scholarship;Scientist;Site;skills;Slide;Spleen;Splenocyte;Students;symposium;Techniques;The Jackson Laboratory;tissue fixing;Tissues;tool;Training;tumor;Underrepresented Minority;ventilation;Work;Xenograft procedure

PROJECT_TITLE: Workshop on Techniques in Modeling Human Cancer in Mice

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: BROOMFIELD

ORG_NAME: COLORADO STATE DEPARTMENT/AGRICULTURE

PHR: Colorado AFRPS Maintenance Grant Project Narrative This application is for the funding of maintaining AFRPS implementation for the Colorado Feed Inspection Program.

PI_NAMEs: ZIEHR, SCOTT  (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, SOMA

PROJECT_TITLE: Maintenance of the Colorado Animal Feed Regulatory Program Standards  (U18)


ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Narrative The extensive use of antibiotics has led to the evolution of “super bugs” resistant to all current treatments despite medicine's best efforts to identify new antibiotics and, perhaps more importantly, new targets for drug development. One of nature's most successful strategies has been to inhibit enzymes in bacterial peptidoglycan biosynthesis and targeting this pathway has been historically quite successful in treating bacterial infections. The program proposed here aims to gain a detailed understanding of a critical membrane embedded players in the pathway providing new routes for designing novel broad-spectrum antibacterial agents.

PI_NAMEs: CLEMONS, WILLIAM M. (contact);KUROSU, MICHIO

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Anabolism;analog;Anti-Bacterial Agents;anti-cancer therapeutic;Antibiotic Resistance;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;Binding;Biochemical;Biochemistry;Biological Assay;Cell Wall;Clinic;Complex;Data;Dedications;design;Development;Drug Design;drug development;drug discovery;drug resistant pathogen;Drug Targeting;Effectiveness;Encapsulated;Environment;enzyme biosynthesis;Enzyme Inhibition;Enzymes;Evolution;Funding;Goals;Grant;Health;Homologous Gene;Homologous Protein;Human;Hydrophobic Interactions;improved;inhibitor;innovation;insight;interest;Investigation;Knowledge;Lead;Libraries;Life;Lipid Bilayers;Lipids;Medical;Medicine;Membrane;Modernization;Molecular Target;multi-drug resistant pathogen;nanobodies;nanodisk;Natural Products;Nature;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;pathogenic bacteria;Pathway interactions;Peptidoglycan;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phosphotransferases;Play;programs;Property;Proteins;Reagent;reconstitution;Resistance;resistant strain;Resources;Role;Route;Scheme;Series;small molecule;small molecule inhibitor;Source;Structural Biologist;structural biology;Structure;success;Synthesis Chemistry;Therapeutic;therapeutic target;tool;translocase;Tunicamycin;Viral Proteins;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanistic details of key integral membrane enzymes for antimicrobial discovery


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Microbes require unique biochemical strategies to adapt to changing environmental conditions, such as oxygen limitation. We will define the chemical and biological functions of a new class of metalloenzymes abundant in commensal and pathogenic bacteria that inhabit oxygen-depleted niches in the human body. This work will achieve a fundamental understanding of anaerobic biochemistry in microbial pathogenesis to reveal novel targets for antibacterial therapeutics.

PI_NAMEs: RAJAKOVICH, LAUREN JULIA (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Aerobic;Anabolism;Anti-Bacterial Agents;Antibiotic Resistance;Biochemical;Biochemical Reaction;Biochemistry;Bioinformatics;Biological;Biological Process;Catalysis;Cell Physiology;chemical function;Chemistry;cofactor;commensal bacteria;Drug resistance;Environment;environmental change;Enzymes;Family;Gastrointestinal tract structure;Genomics;Goals;gut microbes;host-microbe interactions;Human;Human body;Hydroxylation;Knowledge;Lung;member;metalloenzyme;Microbe;microbial;Modification;Molecular;Mucous Membrane;novel;novel therapeutics;Oxidases;Oxidation-Reduction;Oxygen;Pathogenesis;pathogenic bacteria;Play;programs;Proteins;Reaction;Reactive Oxygen Species;Research;response;RNA;Role;Source;Therapeutic;Work;wound

PROJECT_TITLE: Deciphering microbial metalloenzyme functions in microaerobic host environments


ADMINISTERING_IC: DK

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative (Overall)  The kidney is a vital organ that maintains minute-to-minute regulation of blood composition, a process that occurs through a complex organization of cells and structures into functioning units. The goal of this project is to create a comprehensive spatial map of the various types of molecules using state of the art technologies that will provide a readable and integrated output spanning regulation of genes, gene expression, proteins, metabolites, lipid and extracellular mass at a single cell resolution. Through studying kidney tissue from a representative diverse population, this work will provide key understanding of the functions of the kidney and the changes that occur with aging and disease.

PI_NAMEs: ASHKAR, TAREK MAURICE;JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;absorption;Acids;Acute;Adult;Affect;Age;Aging;Anatomy;ATAC-seq;Atlases;base;biobank;Biodiversity;Biological Assay;biological heterogeneity;Biology;Biomedical Engineering;Biopsy;Blood;blood filtration;blood pressure regulation;career;Cell Nucleus;cell type;Cells;Cellular biology;Chromatin;Chronic;Clinical;cohort;Collaborations;Communities;Complex;Data;Data Analyses;data integration;data pipeline;Data Set;design;Dimensions;disadvantaged student;Disease;Disease Outcome;Drug Targeting;Educational Activities;Electrolyte Balance;empowerment;End stage renal failure;environmental enrichment for laboratory animals;Epigenetic Process;epigenome;Equilibrium;Erythropoiesis;Ethnic Origin;extracellular;Extracellular Matrix Proteins;Fluorescence Microscopy;Fostering;gain of function;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;genome-wide;Goals;Health;Human;Human BioMolecular Atlas Program;Image;Immune;Immunofluorescence Immunologic;innovation;insight;Institution;Internships;Kidney;Kidney Diseases;Knowledge;Label;Life;Light;Link;Lipids;Maps;men;Metadata;Microscopic;Microscopy;Molecular;Molecular Biology;Molecular Structure;multimodal data;multimodality;multiple omics;Nebraska;Neighborhoods;Nephrons;Nerve;neurovascular;Organ;Output;Oxidation-Reduction;Pathology;Pathway interactions;Patients;Persons;Phase;Physicians;Physiology;Population Heterogeneity;precision medicine;Process;Productivity;Proteins;Race;Raman Spectrum Analysis;Readability;Regulation;Renal function;Research Personnel;Resolution;Resources;RNA;Sampling;Scientist;sex;single cell technology;Small Nuclear RNA;Sodium Chloride;solute;Source;Structure;Students;Technology;Textbooks;Tissues;tool;Transcript;transcriptome;transcriptomics;Underrepresented Students;Vision;Water;water conservation;Woman;Work

PROJECT_TITLE: Kidney single cell and spatial molecular atlas project - KIDSSMAP


NIH_SPENDING_CATS: Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: JAIN, SANJAY  (contact)

PROJECT_TERMS: 3-Dimensional;Age;analysis pipeline;Anatomy;Atlases;Biological Assay;cell type;Cells;Characteristics;Chromatin;Communities;Complex;computer infrastructure;computerized tools;Data;Data Analyses;data integration;data modalities;Data Set;data sharing;data submission;Dimensions;Disease;Dissociation;Ensure;experience;Generations;Genetic Transcription;Goals;Human;Human BioMolecular Atlas Program;Individual;Infrastructure;Kidney;Kidney Diseases;Life Cycle Stages;Light;Lipids;Location;Machine Learning;machine learning method;Measurement;member;Metadata;Microanatomy;Microscopy;Modality;Modeling;Modernization;Molecular;Molecular Target;Names;Outcome;Production;Proteins;Quality Control;Race;Reporting;Resolution;RNA;Sampling;sex;single nucleus RNA-sequencing;Site;Slice;Statistical Models;Structure;Subcellular Anatomy;supervised learning;Suspensions;System;Techniques;Tissue atlas;Tissues;tool;transcriptome;Visualization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


PROJECT_TERMS: 3-Dimensional;absorption;Adult;Anatomy;ATAC-seq;Atlases;Biological Assay;Biopsy;blood pressure regulation;Blood Vessels;Cell Nucleus;cell type;Cells;Chromatin;Clinical;Communities;Complex;Data;Data Analyses;Data Set;Detection;Dimensions;Disease;Drug or chemical Tissue Distribution;Emerging Technologies;Ethics;Extracellular Matrix;Feedback;Filtration;Fluorescence Microscopy;Gene Expression;Genetic Transcription;genome-wide;genomic data;Goals;Heterogeneity;Homeostasis;Human;Human BioMolecular Atlas Program;Immune;Immunofluorescence Immunologic;Immunologic Surveillance;improved;In Situ;Infrastructure;interest;interoperability;Kidney;Label;Life Cycle Stages;life span;Light;Link;Lipids;Lobe;Lobule;Maps;Methods;Microscopy;Modality;Molecular;multimodality;Neighborhoods;Nephrons;Nerve;neurovascular;new technology;Organ;Output;Patients;Phase;Physiological;preservation;Process;Proteins;Protocols documentation;Quality Control;Race;Raman Spectrum Analysis;Resolution;Resources;RNA;Role;Sampling;sex;single nucleus RNA-sequencing;Site;Small Nuclear RNA;solute;Source;Specimen;Technology;tissue processing;Tissues;tool;Transcript;transcriptomics;usability;Water;Work


ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE There are no approved treatments to slow or stop the progression of knee osteoarthritis. Identifying individuals with a high risk of rapidly worsening disease who would most benefit from treatments is an important question to address. In this study, we will identify features on knee x-rays that predict individuals at high risk of rapid deterioration of their knee osteoarthritis.

PI_NAMEs: DURYEA, JEFFREY W;KWOH, C KENT (contact);NELSON, AMANDA E;NEOGI, TUHINA

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;Adult;Affect;Anterior;Clinical;Clinical Research;Clinical Trials;cohort;Computer software;County;Data;Degenerative polyarthritis;demographics;Deterioration;Development;Disease;Disease Progression;Enrollment;Evaluation;experience;FDA approved;Goals;high risk;improved;indexing;Individual;innovation;insight;Intervention;Joints;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Location;Longitudinal, observational study;Magnetic Resonance Imaging;Measures;Medical;Methods;Morbidity - disease rate;novel;Pain;Premature Mortality;prevent;Prevention strategy;Preventive Clinical Trial;Probability;progression risk;Progressive Disease;prospective;Protocols documentation;Public Health;racial difference;racial diversity;radiological imaging;Reproducibility;Research;Research Personnel;Risk;Risk Factors;Roentgen Rays;screening;Sex Differences;Software Tools;Structural defect;structural determinants;substantia spongiosa;Testing;Texture;Time;Visit;Weight-Bearing state;Western Ontario and McMaster Universities Arthritis Index;Width;Work

PROJECT_TITLE: Identifying determinants of rapid structural and/or clinical progression in knee osteoarthritis by quantitative assessment of structural features on radiographs

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endocrine Disruptors;Fibroid Tumors (Uterine);Genetics;Women's Health Research

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: Narrative: The goal of this project is to determine how aberrant metabolism of tryptophan by fibroid tumors contributes to their growth and test novel therapies aimed at normalizing tryptophan metabolism for treatment of fibroids

PI_NAMEs: KHORRAM, OMID A. (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: African American population;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Binding;Catabolism;Caucasians;Cell Cycle Proteins;cell growth;Cell Proliferation;Collagen;CYP1B1 gene;Data;design;Development;Diet;Dietary Factors;Endocrine Disruptors;Environmental Risk Factor;enzyme activity;Enzymes;Epigenetic Process;Exposure to;Extracellular Matrix;Fibroid Tumor;Gene Expression;Genes;Goals;Gonadal Steroid Hormones;Growth;Hispanic Populations;Hormonal;Hydrocortisone;In Vitro;in vivo;Inflammation;inhibitor;innovation;knock-down;Kynurenine;Leiomyoma;Lentivirus;Link;Messenger RNA;Metabolic;Metabolic Pathway;mouse model;mRNA Expression;Mutation;myometrium;NF-kappa B;novel;novel therapeutics;overexpression;Pathogenesis;pharmacologic;Proliferating;protein expression;Quantitative Reverse Transcriptase PCR;Race;Reaction;Receptor Signaling;Reporting;Response Elements;Risk Factors;Role;Sampling;small hairpin RNA;Smooth Muscle Myocytes;Specimen;spheroids;Stress;Testing;Tetrachlorodibenzodioxin;Tissues;transcription factor;transforming growth factor beta3;translational potential;trend;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;tumor;Untranslated RNA;Western Blotting;Xenobiotics

PROJECT_TITLE: Tryptophan metabolism and its role in fibroid pathogenesis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Mutations in Complement Factor H (CFH) that interfere with heparan sulfate (HS) binding are major risk factors for age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Although, the roles of CFH and HS in AMD are not understood, preliminary data demonstrate that interactions between HS and a CFH homolog are required for cilia compartment organization in C. elegans sensory neurons and this function appears to be conserved in human photoreceptors. The molecular genetic dissection of these novel CFH and HS functions proposed here will provide substantial insight into a previously unappreciated mechanism for AMD pathogenesis.

PI_NAMEs: VOGEL, BRUCE E (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Adult;Affect;Afferent Neurons;Age;Age related macular degeneration;Alternative Complement Pathway;Autopsy;Binding;Binding Sites;Biological Assay;Blindness;Caenorhabditis elegans;Cell Physiology;Cell surface;Cessation of life;Cilia;Complement Factor H;complement pathway;Data;Defect;Deposition;design;Disease;Dissection;Drusen;Enzymes;Epithelial Cells;follow-up;Functional disorder;gene product;Genes;Genetic;Genetic Screening;Genetic Techniques;genome wide screen;Genotype;Goals;Health Care Costs;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Heparitin sulfotransferase;Homeostasis;Homologous Gene;Human;Individual;induced pluripotent stem cell;Inflammation;inflammatory milieu;insight;Lipids;Location;loss of function mutation;Maps;Membrane;Missense Mutation;Modeling;Molecular;Molecular Genetics;mutant;Mutation;Nephronophthisis;Neurons;next generation sequencing;novel;Organoids;Pathogenesis;Pathogenicity;Patients;Phenotype;Photoreceptors;Proteoglycan;Retina;Risk Factors;Role;screening;Structural defect;Structure;Structure of retinal pigment epithelium;sulfotransferase;syndecan;Testing;Time;Tissues;United States;Universities;Variant;Work

PROJECT_TITLE: Molecular Genetics of a Complement Factor H homolog

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Lung;Organ Transplantation;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative: Median survival after lung transplant is less than six years, largely due to a high incidence of chronic rejection affecting up to 50% of survivors by five years after transplantation. Donor tissue resident memory T cells (TRM) persist within the allograft after transplantation, and recipient TRM are generated; the ratio of these two populations is associated with short-term clinical outcomes. This proposal will test the relationship between donor TRM persistence and recipient TRM generation on the risk of premature chronic rejection after lung transplantation, with the goal of discovering new therapeutic targets in the pathogenesis of rejection.

PI_NAMEs: SNYDER, MARK EUGENE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acute;Acute Lung Injury;adaptive immunity;Affect;airway obstruction;Allografting;analytical tool;Biological Assay;Biological Response Modifiers;Bronchiolitis Obliterans;Bronchoalveolar Lavage;CD28 gene;CD3 Antigens;Cell Survival;Cells;Chronic;Clinical;Clinical Trials;Clonal Expansion;Clonality;cohort;Consent;Cox Proportional Hazards Models;Critical Care;cross reactivity;Cytomegalovirus;cytotoxic;cytotoxicity;Data;Data Analyses;design;Development;early onset;Flow Cytometry;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genomics;Goals;graft dysfunction;Heart Transplantation;HLA Antigens;Human;Hypersensitivity;immunogenic;Immunology;improved;Incidence;Individual;Infection;Infiltration;Inflammatory;inflammatory milieu;Influenza;knowledge base;Laboratories;leadership development;Life Expectancy;Lung;lung allograft;Lung Diseases;Lung infections;Lung Transplantation;Lymphocyte;Lymphoid Tissue;Mediating;Medicine;member;Mentored Patient-Oriented Research Career Development Award;Methodology;Methods;Mixed Lymphocyte Culture Test;Morbidity - disease rate;mortality;Mucous Membrane;Natural Immunity;new therapeutic target;Organ;Organ Donor;Outcome;Participant;pathogen;Pathogenesis;Patients;Peptide Library;Phenotype;Population;premature;Process;Productivity;professor;Proliferating;Publishing;Research;Research Personnel;Research Proposals;Respiratory syncytial virus;Risk;Running;Science;single-cell RNA sequencing;skills;Solid;Specificity;Stains;Survivors;Syndrome;T cell clonality;T cell receptor repertoire sequencing;T memory cell;T-Cell Immunologic Specificity;T-Cell Receptor;T-Cell Receptor Genes;T-Lymphocyte;Testing;Therapeutic;therapeutic target;Tissue Donors;tissue resident memory T cell;translational immunology;Transplant Recipients;transplant survivor;Transplantation;trend;Universities;Viral;Virus;Work

PROJECT_TITLE: Impact of tissue resident memory T cells on chronic rejection after lung transplantation


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: BATON ROUGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

PHR: Project Narrative The repeated administration of Gd(III)-based MRI contrast agents raises significant concerns due to the potential for in vivo deposition, hypersensitivity, and lethal systemic fibrosis. We propose to develop discrete (Đ = 1.0) brush polymer-based 19F-MRI contrast agents to overcome the longstanding challenges of dispersity, size, rapid renal clearance, and low signal-to-noise ratio of synthetic contrast agents. If the proposed study is successful, it will provide metal-free MRI contrast agents that are safer, selective, more reliable, and chemically versatile for the diagnosis and monitoring of damaged blood vessels, small tumors, and abnormal tissues.

PI_NAMEs: LAWRENCE, JIMMY  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Architecture;biomaterial compatibility;blood damage;Blood Vessels;Chemicals;Clinical;clinical application;Contrast Media;Deposition;Development;Diagnosis;Equilibrium;Fibrosis;hydrophilicity;Hypersensitivity;in vivo;lipophilicity;Magnetic Resonance Imaging;Metals;Molecular Weight;Monitor;Noise;Phospholipids;Phosphorylcholine;Polymers;rational design;Renal clearance function;Signal Transduction;System;targeted imaging;Tissues;tumor;Water;water solubility

PROJECT_TITLE: Discrete Polymer-based, Metal-free MRI Contrast Agents


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Substance Misuse

ORG_CITY: BOZEMAN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: Project Narrative This project addresses a critical gap in knowledge regarding the relationship between historical and childhood trauma and health risk in an American Indian (AI) community. Using a community based participatory approach, gold-standard physiological reactivity methods, and comprehensive assessments of behavioral and biological risk for cardiometabolic disease and mental health, the findings will provide important knowledge on the relationship between trauma and disease risk in AIs. The study will provide the basis for future longitudinal work to track the impact of trauma on long-term trajectories in cardiometabolic and mental health risk and will provide foundational knowledge that can be applied to future health interventions aimed at reducing AI health disparities.

PI_NAMEs: GINTY, ANNIE T;JOHN-HENDERSON, NEHA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accounting;Acute;acute stress;Address;Adult;Age;Alcohol consumption;alcohol measurement;American Indian community;American Indian Population;American Indians;Anxiety;arterial stiffness;Behavior assessment;Biological;Biological Markers;biological sex;Blackfeet;Blood Pressure;Blood specimen;Buffers;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Childhood;Collaborations;Communities;community advisory board;community based participatory approach;community based participatory research;County;Cross-Sectional Studies;Data;depressive symptoms;design;disorder risk;Emotional;Ensure;Equation;Ethnic Population;experience;Exposure to;Female;Future;Generations;Glucose;Goals;Health;Health behavior;health disparity;health disparity populations;Immune system;Incidence;Individual Differences;Inflammation;Inflammatory;Inflammatory Response;Intervention;Knowledge;Laboratories;Language;Life Expectancy;life span;Link;Longitudinal cohort;Measures;member;Mental Health;Methods;Modeling;Montana;mortality;Neurosecretory Systems;Not Hispanic or Latino;Obesity;Outcome;Participant;Pathway interactions;pediatric trauma;Persons;physical conditioning;Physiological;Premature Mortality;Prevalence;Protocols documentation;psychologic;Psychological Stress;Race;racial population;Reaction;Reporting;Research;research study;Reservations;resilience factor;response;Rest;Risk;Risk Factors;Risk Marker;Role;Sampling;social;Standardization;Stress;stressor;substance use;System;Testing;Training;transmission process;Trauma;Visit;waist circumference;Work;wound;young adult

PROJECT_TITLE: Trauma and Cardiometabolic Health in an American Indian Community

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_NAME: ALTIUS INSTITUTE FOR BIOMEDICAL SCIENCES

PHR: PROJECT NARRATIVE The human regulatory genome plays a crucial role in the coordination of gene expression in health and disease but remains poorly understood. This application proposes a general framework for elucidating the organizing principles of the regulatory genome through large-scale data integration, from a common coordinate system for regulatory elements to their universal annotation and in-depth characterization. This work will generate insights and testable hypotheses for the study of basic gene regulatory processes, interpretation of genetic variation and synthetic biology efforts, which are all key areas contributing to the understanding and treatment of human disease.

PI_NAMEs: MEULEMAN, WOUTER  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Area;cell type;Cells;Chromatin;Communities;Data;Data Analyses;data integration;Data Set;design;Disease;Elements;functional genomics;Gene Expression;Genes;Genetic Variation;Genome;genome annotation;genome wide association study;genome-wide analysis;Genomics;Health;Human;human disease;Human Genome;Individual;insight;Instruction;large scale data;lens;Methods;Open Reading Frames;Pattern;Play;Process;Regulatory Element;Research;Resources;Role;synthetic biology;System;Systems Biology;tool;trait;Untranslated RNA;Variant;Work

PROJECT_TITLE: Elucidation of the organizing principles of the regulatory genome through large-scale data integration


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: MALVERN

ORG_NAME: LIFESENSORS, INC.

PHR: PROTACs, bifunctional small molecules that bind to a ubiquitin E3 ligase at one end and a target protein at the other, degrading the bound target protein, are a promising new drug class. We describe methods for rapid development of tau PROTACs drugs. We have proposed strategies to discover novel PROTACs that will remove pathogenic (monomeric) tau proteins as well as aggregates through autophagic mechanism. Development of the technology that degrades tau aggregates can be directly applied to Parkinson’s disease, Huntingdon disease, and Amyotrophic Lateral Scleroses.

PI_NAMEs: BUTT, TAUSEEF R. (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: abeta accumulation;Academia;Acceleration;Affect;Alzheimer's Disease;Alzheimer's disease therapy;Amyotrophic Lateral Sclerosis;analog;Antibody Therapy;Antineoplastic Agents;Autophagocytosis;Autophagosome;Binding;Brain region;Cell Death;Cell model;Cells;chimera drug;Chromatin;Clinic;Complex;Consumption;Cullin Proteins;Data;design;Development;Disease;drug discovery;Family;Frontotemporal Dementia;G-Protein-Coupled Receptors;Gel;Goals;Grant;Histones;Human;hyperphosphorylated tau;induced pluripotent stem cell;Industry;infancy;Ligands;Ligase;Lysosomes;MDM2 gene;Mediating;member;Membrane Proteins;Methods;misfolded protein;Mitochondria;Modality;Modeling;Monitor;monomer;Monoubiquitination;Morphologic artifacts;multicatalytic endopeptidase complex;mutant;nerve stem cell;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;novel;novel drug class;novel strategies;novel therapeutics;Nucleosomes;overexpression;paired helical filament;Parkinson Disease;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Play;Polyubiquitin;Polyubiquitination;pre-clinical;Progress Reports;Progressive Supranuclear Palsy;Protac;protein aggregation;protein degradation;protein transport;Proteins;Proteome;rapid technique;Recycling;Reporter Genes;Research;Research Personnel;Resistance;Revlimid;Role;screening;Signal Transduction;small molecule;Specificity;success;System;tau aggregation;tau mutation;tau Proteins;Tauopathies;Technology;technology development;Testing;Thalidomide;Time;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Western Blotting

PROJECT_TITLE: Novel Approaches for Tau PROTAC Drug Discovery


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: STILLWATER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE Tuberculosis remains one of the deadliest infectious diseases in humans. The findings from this project will provide potential targets for developing novel host-directed therapies for tuberculosis.

PI_NAMEs: CHENG, YONG  (contact);LIU, LIN

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: adenoviral mediated;Bacterial Infections;Binding;Binding Proteins;Biology;CCAAT-Enhancer-Binding Protein-beta;Cell Culture Techniques;Cells;Cessation of life;Communicable Diseases;Data;Development;Enhancers;fetal;Gene Transfer;Genetic Transcription;Goals;Growth;Homeostasis;Homologous Gene;Host Defense;Human;In Vitro;in vivo;Infection;IRE-Binding Protein;Iron;knock-down;Knockout Mice;Lung;Macrophage;Mammalian Cell;Mediating;microbial;MicroRNAs;Modeling;mouse model;Mus;Mycobacterium tuberculosis;novel;Nucleotides;overexpression;p38 Mitogen Activated Protein Kinase;pathogen;pathogenic bacteria;Pathway interactions;Predisposition;promoter;Proteins;Public Health;Regulation;Reporting;response;RNA;Role;Testing;TLR2 gene;Transcript;transcription factor;Tuberculosis;tuberculosis treatment;Untranslated RNA;Up-Regulation

PROJECT_TITLE: The role of FENDRR in host defense against Mycobacterium tuberculosis infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Humans can show tremendous flexibility in every day life, rapidly recognizing and responding to contextual cues with appropriate behavioral changes, even in unfamiliar situations where the appropriate behaviors could not have been learned through direct experience. Here we examine the neural basis of this flexibility, with a particular focus on how arousal signals elicited by perceived context changes might coordinate neural representations in the brain to facilitate appropriate behaviors in changing and unfamiliar situations. This work will provide an understanding of how the brain generates flexible behavior, and why it does so differently in different individuals, thereby serving as a foothold for future work seeking to understand what goes wrong in conditions characterized by failure to cope with uncertain and changing environments.

PI_NAMEs: NASSAR, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Accidents;Adopted;Affect;Algorithms;Anxiety Disorders;Arousal;Attention deficit hyperactivity disorder;Attentional deficit;automobile accident;Basic Science;Behavior;behavior influence;behavior prediction;Behavioral;Brain;Cognitive;Complex;computational neuroscience;computer framework;Computer Models;coping;COVID-19;Cues;Data;Dependence;design;Diameter;Effectiveness;Electroencephalography;Environment;EP300 gene;Etiology;experience;experimental study;Failure;flexibility;Functional Magnetic Resonance Imaging;Future;Goals;Human;Impairment;Individual;Individual Differences;Instruction;inter-individual variation;Learning;learning algorithm;Life;Link;locus ceruleus structure;Masks;Measures;Mediating;Mental disorders;Mental Health;Modeling;Nature;neural;neuromechanism;Norepinephrine;norepinephrine system;novel;Participant;Pattern;Peripheral;personalized predictions;Persons;Pharmaceutical Preparations;pharmacologic;Play;Policies;post-COVID-19;predictive modeling;Process;Proxy;Pupil;research study;response;Reversal Learning;Rodent;Role;Signal Transduction;Structure;Testing;theories;therapeutic target;Time;tool;Update;validation studies;Work

PROJECT_TITLE: Representational dynamics for flexible learning in complex environments

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The overarching goal of the Indiana Core Center for Clinical Research (ICCCR) – the Indiana Center for Musculoskeletal Health Clinical Research Center (ICMH-CRC) is to provide the needed training and resources for investigators to enhance clinical research in musculoskeletal disorders across a broad range of diseases and populations.

PI_NAMEs: MOE, SHARON M (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Accounting;Affect;Age;aging population;Area;Autocrine Communication;Big Data;biobank;bone;Caring;Chronic Disease;Classification;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Communities;community engagement;Community Health;Complex;Computers;cost;COVID-19;Data;Data Analyses;Data Collection;Data Mart;data standards;Databases;Diabetes Mellitus;Diagnosis;dietary;disability;Discipline;Disease;Disparity population;DNA;Dual-Energy X-Ray Absorptiometry;Electronic Health Record;Endocrine;Environmental Risk Factor;ethnic diversity;Ethnic Origin;Exercise;exome sequencing;falls;Food;Fostering;Fracture;Functional disorder;Funding;Genetic;genomic data;Genomics;Goals;Government;Growth;Health;Health Care Visit;Image;improved;Indiana;Individual;Informatics;Injury;innovation;International;Interruption;Joints;Kidney Diseases;life span;Link;Liver diseases;Malignant neoplasm of liver;Manuscripts;Measures;Mechanics;member;Metabolic;Methodology;Minority Groups;Mission;Morphology;Motivation;multiple data sources;Muscle;Musculoskeletal;Musculoskeletal Diseases;Neighborhood Health Center;next generation;novel;nutrition;Obesity;Participant;Patient Education;Patients;Pattern;Phenotype;Physical Function;physical impairment;Population;Population Heterogeneity;Prevention;Process Assessment;programs;prospective;Publishing;Quality of life;Questionnaires;Race;racial diversity;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Sampling;sarcopenia;Screening procedure;Secure;Services;sex;Site;social determinants;Standardization;structural health determinants;Surveys;Techniques;Testing;tissue resource;Tissues;Training;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Indiana Core Center for Clinical Research in Musculoskeletal Health


PROJECT_TERMS: Algorithms;Award;Awareness;Budgets;Chronic Disease;Clinical;clinical center;Clinical Research;clinical translation;Cohort Studies;Collaborations;collaborative environment;Communication;Communities;community engagement;Community Health;Consultations;COVID-19 pandemic;Data;Data Mart;Development;Diagnosis;Dietary Practices;Discipline;doctoral student;Educational workshop;Electronic Health Record;Enrollment;Ensure;equity, diversity, and inclusion;ethnic diversity;Evaluation;Exposure to;Feedback;Funding;genomic data;Goals;Government;Grant;Health;Health Professional;health training;Image;Indiana;Individual;Industry Collaboration;Informatics;innovation;Interest Group;Lead;Leadership;Learning;lectures;Location;Manuscripts;meetings;Methodology;Mission;Morphology;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;Online Systems;outreach;outreach program;participant enrollment;performance tests;Periodicals;Phenotype;Physical Function;Physical Performance;Physicians;Pilot Projects;Population Heterogeneity;Prevention;programs;prospective;Publications;Publishing;racial diversity;Research;Research Personnel;Resources;Rotation;Sampling;Services;Site;social;social determinants;Source;Standardization;structural health determinants;Students;success;Surveys;symposium;Technology;Testing;tissue resource;Tissues;Training and Infrastructure;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PI_NAMEs: IMEL, ERIK ALLEN (contact)

PROJECT_TERMS: artificial intelligence method;Back;bench to bedside;Big Data;biobank;Biology;Blood specimen;bone;bone imaging;Characteristics;Clinical;clinical center;clinical phenotype;Clinical Research;Clinical Trials Design;Code;cohort;collaborative approach;Communities;Complex;computable phenotypes;Consultations;Data;data integration;Data Mart;data quality;Data Science;Data Set;Data Sources;data standards;design;Development;Diagnosis;disability;Disease;Disparate;diverse data;electronic health information;Electronic Health Record;electronic health record system;Environmental Risk Factor;epidemiology study;exome sequencing;falls;Foundations;Fracture;Functional disorder;Funding;genomic data;Genomics;Genotype;Goals;Grant;Health;Human;Image;image processing;improved;Indiana;Individual;Informatics;Information Systems;innovation;Interdisciplinary Study;Laboratories;life span;Link;machine learning method;machine learning model;Measurement;Measures;Mediating;metabolomics;Metastatic Neoplasm to the Bone;Methodology;Methods;Molecular;Morphology;multidisciplinary;multiple data sources;Muscle;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal injury;Natural Language Processing;new technology;novel;Osteoporosis;Outcome;Participant;Patient Care;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Population;predict clinical outcome;Prospective Studies;Proteomics;Public Health Informatics;public health intervention;query tools;real world application;Research;Research Design;Research Personnel;Resource Informatics;Resources;Retrospective Studies;Risk Factors;sarcopenia;Science;Secure;Services;social;social determinants;social factors;social health determinants;Source;Specimen;Standardization;Statistical Data Interpretation;structural health determinants;success;Systems Biology;Technology;Text;Tissue Sample;tool;Training;Translating;Translational Research;World Health

PROJECT_TITLE: Method Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Inflammatory Bowel Disease;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE According to the Center for Disease Control and Prevention, an estimated 1.4 million Americans suffer from Inflammatory Bowel Disease (IBD), a chronic debilitating disorder that includes Crohn’s disease and ulcerative colitis. IBD ranks in the top 5 in prevalence for gastrointestinal disorders and represents a significant financial burden to society requiring a lifetime of medical care as there is no cure for this disease. This proposed research aims to determine the genetic variations that cause IBD which will aid in developing preventive measures, improving the quality of care with better treatment plans and educating patients through genetic counseling.

PI_NAMEs: BRANT, STEVEN R (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Admixture;African;African American;African American population;African ancestry;Alleles;American;ATAC-seq;Caring;Cell Separation;Cells;Centers for Disease Control and Prevention (U.S.);Chromatin;Chromosome Mapping;Chronic;Clinical;Complex;Crohn's disease;Data;Data Coordinating Center;Diagnosis;diagnostic algorithm;Digestive System Disorders;Disease;disease phenotype;disease-causing mutation;East Asian;Epigenetic Process;European;Evaluation;Financial Hardship;Funding Mechanisms;Gastrointestinal Diseases;Gene Expression;Gene Targeting;Genes;Genetic;genetic association;Genetic Counseling;Genetic Diseases;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genome-wide;Genotype;Goals;Health;Hispanic;Immune;Immune System Diseases;improved;Inflammatory Bowel Diseases;insight;International;Investigation;Knowledge;Latinx population;Leadership;Linkage Disequilibrium;Literature;Maps;Mediating;Medical;Meta-Analysis;Molecular Genetics;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;Outcome;Participant;Patient Recruitments;Patient-Focused Outcomes;Patients;Phenotype;Play;pleiotropism;Population;Positioning Attribute;Postoperative Period;Prevalence;Prevention strategy;Preventive measure;Probability;Quality of Care;rare variant;receptor;recruit;Recurrent disease;Research;Resources;Risk;Risk Factors;risk variant;Role;Sensitivity and Specificity;sex;Societies;Specialist;Structure;targeted treatment;TNFSF15 gene;trait;transcriptome;transcriptome sequencing;treatment disparity;treatment planning;Ulcerative Colitis;Untranslated RNA;Variant;whole genome;X Chromosome

PROJECT_TITLE: IBD Gene Mapping by Clinical and Population Subset


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: WARDEN, STUART J (contact)

PROJECT_TERMS: Address;adverse outcome;biobank;Biological;Biopsy;Body Composition;bone;bone mass;Cataloging;Catalogs;Center Core Grants;Chronic;Chronic Disease;Clinical;clinical center;Clinical Data;Clinical Research;Collaborations;Communities;computable phenotypes;Computed Tomography Scanners;Consent;cost;Data;Data Set;data sharing;Databases;Dietary Practices;disability;Disease;DNA;Dual-Energy X-Ray Absorptiometry;Electronic Health Record;Ensure;ethnic diversity;Ethnic Origin;exome sequencing;Feedback;field study;Fostering;Fracture;Funding;genomic data;Genomics;Goals;Growth;Health;Image;Impairment;improved;Indiana;Individual;Informatics;innovation;Institution;Institutional Review Boards;Investigation;investigator training;Link;member;Methodology;Morbidity - disease rate;Morphology;mortality;Muscle;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;Musculoskeletal System;Neighborhood Health Center;novel;Organ;Outcome;Participant;Patient-Focused Outcomes;Performance;Peripheral;Phenotype;Physical assessment;Physical Function;Physical Performance;Population;Property;Protocols documentation;Race;racial difference;racial diversity;Research;Research Personnel;Resolution;Resources;Retrieval;sample collection;Sampling;Scanning;social health determinants;Source;Specimen;Standardization;Techniques;Testing;Thinness;Time;tissue resource;Tissues;Training;United States National Institutes of Health;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: Resource Core


NIH_SPENDING_CATS: Genetics;Microbiome

PHR: The goal of this project is to develop novel activity-targeted approaches to catapult the human gut microbiome field into an era of single cell ecophysiology investigations. Specifically, mucosal biopsy samples will be analyzed by a combination of substrate analog probing, stable isotope probing, Raman microspectroscopy, and correlative microscopy approaches, which together will reveal the identity, activity, and function of gut microorganisms at individual cell resolution under close-to in situ conditions.

PI_NAMEs: HATZENPICHLER, ROLAND  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Amendment;analog;Biochemistry;Biopsy Specimen;Cell Separation;Cells;Chemicals;Complex;DNA;Ecology;Ecosystem;Electron Microscopy;Fluorescence Microscopy;Fluorescence-Activated Cell Sorting;Fluorescent in Situ Hybridization;Gastrointestinal tract structure;Gene Expression;Genotype;Goals;Growth;gut microbiome;Human;Image;In Situ;Individual;Investigation;Label;Link;Lipids;member;Metabolic;Metagenomics;Methods;Microbe;microbial;microbiome research;microorganism;Microscopy;Microtomy;Mucous Membrane;next generation;novel;Peptidoglycan;Phenotype;Physiology;Proteins;Resolution;response;Sampling;Shotguns;Source;Spectrum Analysis;stable isotope;Structure;Taxonomy;Techniques;Technology;Testing;Visualization;X ray spectroscopy

PROJECT_TITLE: Developing Next-Generation Physiology approaches for human gut microbiome research


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: Project Narrative The proposed studies will utilize our newly developed state-of-the-art tools to block or modify the C activation products to investigate the role of C in endothelial cell damage, platelet activation, and thrombosis formation seen in severe COVID-19, including therapeutic paradigms. The significance of our proposed research lies in the fact that it will help us better understand the role of C activation and the MAC in pathogenesis of severe COVID-19, open a new avenue to prevent and treat COVID-19, and foster the development of new therapeutic strategies involving modulation of the C system

PI_NAMEs: QIN, XUEBIN  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;activation product;Acute Respiratory Distress Syndrome;Address;Alveolar;Aneurysm;Animal Model;Atherosclerosis;Attenuated;Biological Availability;Blood Platelets;Body Weight decreased;cell injury;Cell membrane;Cells;Clinical Trials;clinically relevant;Coagulation Process;Communicable Diseases;Complement;Complement 3 Convertase;Complement 5a;Complement Activation;Complement Membrane Attack Complex;complement system;COVID-19;COVID-19 prevention;COVID-19 severity;COVID-19 treatment;Deposition;Development;Endothelial Cells;Endothelium;Erythrocytes;Fostering;Functional disorder;Hemolysis;Human;immune activation;Immunology;Infection;Inflammation;inhibitor;interest;interstitial;Investigation;K-18 conjugate;Knock-in;Knock-out;Lung;Macrophage;Mannose Binding Lectin;Mediating;membrane assembly;Modeling;Monoclonal Antibodies;mortality;Mus;Myeloid Cell Activation;Myeloid Cells;novel therapeutic intervention;Organ;overexpression;Pathogenesis;Pathologic;Pathway interactions;Platelet Activation;Predisposition;Rationalization;Research;response;Risk;Role;Safety;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;SARS-CoV-2 variant;secondary infection;severe COVID-19;single-cell RNA sequencing;Site;System;Testing;Therapeutic;therapeutic evaluation;Thrombosis;tool;Transgenic Mice;Vascular Diseases;vascular inflammation;Vascular Permeabilities

PROJECT_TITLE: Role of Complement Activation in Severe COVID-19

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal malignancy and immune-based therapies have been largely unsuccessful to date. This proposal utilizes advances in single-cell transcriptomics and highly multiplexed imaging, paired with recently developed preclinical models of neoantigen-expressing pancreatic cancer and co-clinical profiling of patient samples, to elucidate the molecular and cellular mechanisms of immune evasion in pancreatic cancer. I anticipate that this work will nominate additional targets for immune-based therapy in pancreatic cancer and other cancers.

PI_NAMEs: FREED-PASTOR, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Acceleration;Adaptive Immune System;Adopted;Animals;anti-cancer research;anti-tumor immune response;Award;Cancer Biology;cancer cell;cancer immunotherapy;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Compartmentation;Cell Physiology;Cells;Clinical;Clinical Trials;combat;Combination immunotherapy;Cytotoxic T-Lymphocytes;Dana-Farber Cancer Institute;Development;Digit structure;Disease;Effectiveness;Evaluation;exhaustion;experience;Flow Cytometry;Functional disorder;Goals;granulocyte;Heterogeneity;Histopathology;Human;imaging modality;Immune;immune clearance;Immune Evasion;Immune response;Immune system;Immune Targeting;Immunofluorescence Immunologic;Immunologic Surveillance;Immunotherapy;improved;improved outcome;insight;interest;International;Lead;Malignant neoplasm of pancreas;Malignant Neoplasms;Mentors;Mentorship;Modeling;Molecular;multiplexed imaging;Mus;Myelogenous;Myeloid-derived suppressor cells;neoantigens;Pancreatic Adenocarcinoma;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Patients;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Prognosis;programmed cell death protein 1;Proteome;Public Health;Research;Research Personnel;Resected;Resistance;resistance mechanism;Resolution;Resources;response;Sampling;single-cell RNA sequencing;spatiotemporal;Specificity;Survival Rate;T cell infiltration;T cell response;T-Lymphocyte;Techniques;Technology;Therapeutic;therapeutically effective;Time;TNFRSF5 gene;Training Programs;transcriptomics;tumor;tumor immunology;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;tumorigenesis;Work

PROJECT_TITLE: Elucidating the molecular and cellular mechanisms of immune evasion in pancreatic cancer

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Zn2+ has emerged as an essential neuromodulator, and dysregulation of synaptic Zn2+ has been linked to numerous neurological disorders, such as stroke/ischemia, epilepsy, depression, Alzheimer’s disease, and hearing disorders. This project aims to develop new technology for imaging synaptic Zn2+ secretion in awake behaving animals and study the roles of Zn2+ in cortical sound processing. This project will pave the way toward elucidating connections between Zn2+ signaling, information processing, and neurological disorders.

PI_NAMEs: AI, HUIWANG  (contact);TZOUNOPOULOS, THANOS

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Address;Affinity;Alzheimer's Disease;Animals;Auditory area;auditory processing;awake;Binding;Brain;cell type;Cells;Cellular Membrane;Chelating Agents;Color;Cytosol;Development;Directed Molecular Evolution;Engineering;Epilepsy;extracellular;fluorescence imaging;Frequencies;Generations;Genes;Hearing problem;Image;imaging capabilities;Imaging Device;Imaging technology;improved;In Vitro;in vivo;information processing;innovation;Ischemia;knockout gene;Knockout Mice;Link;Location;Membrane;Mental Depression;Mus;Nervous System Disorder;Neurobiology;Neuromodulator;Neurons;neurotransmission;Neurotransmitters;new technology;novel;Oranges;Organelles;Outcome;presynaptic;Productivity;Property;protein transport;Proteins;public health relevance;Research Personnel;response;Role;Sensory;sensory cortex;sensory stimulus;Shapes;Signal Transduction;SLC30A3 gene;sound;sound frequency;spatiotemporal;Specificity;Stimulus;Stroke;Synapses;Synaptic Vesicles;synergism;Testing;Time;trafficking;Transgenic Mice;two-photon;Variant;Vesicle;Viral Vector;Zinc

PROJECT_TITLE: Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound Processing


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Complementary and Integrative Health;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Cerebral ischemia in the form of cardiopulmonary arrest remains one of the leading causes of death and disability in the USA. A major pathological consequence of cardiac arrest is cognitive deficits. This proposal examines the molecular mechanisms by which physical exercise and its potential downstream pathways can ameliorate cognitive deficits following cardiac arrest. The goal is to find novel therapeutic agents that act synergistically with physical exercise that may benefit patients that undergo acute myocardial infarction.

PI_NAMEs: PEREZ-PINZON, MIGUEL A (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acetylation;Acute;Acute myocardial infarction;Affect;aged;Aging;aging population;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Animal Model;animal old age;Animals;Area;Asphyxia;Autopsy;Blood Vessels;Brain;Brain region;Cardiopulmonary Arrest;Cause of Death;Cerebral Ischemia;Chronic;Cognitive;Cognitive deficits;cognitive enhancement;cognitive recovery;Data;Dementia;Development;differential expression;disability;DNA Methylation;Elderly;epidemiology study;Epigenetic Process;exercise intervention;exercise regimen;Exercise Therapy;Exhibits;Female;Functional impairment;Funding;Genes;Genetic Transcription;Goals;Guidelines;Heart Arrest;Heart failure;Hippocampus;Histone H3;Histopathology;Human;Impaired cognition;improved;Induced Heart Arrest;Ischemia;Lead;Light;male;Mediating;Memory;mild cognitive impairment;mode of exercise;Modeling;Modification;Molecular;Morbidity - disease rate;multimodality;neuroprotection;novel;novel therapeutics;Outcome;Pathologic;Pathology;Pathway interactions;Patients;pharmacologic;Physical Exercise;Physical therapy exercises;preservation;Rattus;Recovery;Recovery of Function;Resistance;response;Resveratrol;Risk Factors;Risk Reduction;Septal Nuclei;sex;Stimulus;Survivors;Synapses;synaptic function;Synaptic plasticity;Testing;Thalamic Nuclei;Therapeutic;Therapeutic Agents;Transcription Alteration

PROJECT_TITLE: MECHANISMS OF NEUROPROTECTION AGAINST CARDIAC ARREST

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(02)]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE People with diabetes have a higher risk of developing heart disease, even when they take medications to control their blood sugar and cholesterol levels. A metabolite called alpha-aminoadipic acid is higher in people who experience higher disease risk. We will measure alpha-aminoadipic acid in blood to learn whether it predicts heart disease in people with diabetes, and whether it can be controlled using medication.

PI_NAMEs: FERGUSON, JANE F (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Acids;Address;Affect;Aftercare;Animal Model;Atherosclerosis;Attenuated;Biological Markers;Blood;Blood Glucose;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell model;Cholesterol;Data;data resource;Development;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;Disease Progression;disorder risk;effective therapy;Event;experience;Fenofibrate;follow-up;Functional disorder;Future;Glucose;Heart Diseases;High Density Lipoprotein Cholesterol;High Density Lipoproteins;high risk;Hyperinsulinism;Hypertriglyceridemia;Hypoglycemia;improved;Individual;Insulin;insulin secretion;Kidney Diseases;Knowledge;Learning;Lipids;Measures;Mediator;mitochondrial metabolism;Modeling;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nature;Neuropathy;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;optimal treatments;Outcome;Participant;Persons;Pharmaceutical Preparations;Plasma;Population;Residual state;response;Retinal Diseases;Risk;Risk Factors;Role;Sampling;secondary outcome;Simvastatin;Stroke;targeted treatment;treatment arm;Triglycerides

PROJECT_TITLE: The role of alpha-aminoadipic acid (2-AAA) in residual CVD risk in T2D


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_STATE: PA

PHR: Project Narrative Young adults involved in the criminal justice system are at an increased risk of substance use disorders and HIV-acquisition. Given the disproportionate number of racial/ethnic minority young adults, criminal justice settings provide an opportunity to reduce racial/ethnic disparities in HIV and substance use treatment engagement by linking these young adults with innovative biomedical HIV prevention strategies (e.g., pre- exposure prophylaxis) and substance use treatment services. We propose to examine the feasibility, acceptability, and impact of an eHealth enhanced, adapted navigator program designed to refer and link justice involved young adults (18 to 29 years) to substance use treatment and HIV-prevention services.

PI_NAMEs: DAURIA, EMILY F (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;aged;AIDS prevention;alcohol abuse prevention;Awareness;behavioral health;behavioral health intervention;Case Management;Characteristics;Communities;Community of Practice;Consolidated Framework for Implementation Research;Continuity of Patient Care;coronavirus pandemic;Criminal Justice;design;Development;disorder prevention;Drug abuse;Drug Compounding;effective intervention;Effectiveness;efficacy testing;eHealth;Enhancement Technology;ethnic disparity;ethnic minority;evidence base;Feasibility Studies;feasibility testing;Feedback;Focus Groups;follow-up;Future;Goals;health care availability;Health Technology;Healthcare;high risk;HIV;HIV Seropositivity;implementation process;Imprisonment;Improve Access;improved;Individual;innovation;interest;Intervention;intervention delivery;Interview;Justice;Lead;Learning;Link;Mental Health;Modeling;Movement;multidisciplinary;navigator intervention;parole;Participant;Persons;Phase;Pilot Projects;pilot trial;Population;population health;pre-exposure prophylaxis;prevention service;Prevention strategy;Prevention trial;preventive intervention;primary outcome;probation;Process;programs;Provider;Publishing;racial disparity;racial minority;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Risk;Risk Behaviors;San Francisco;satisfaction;service intervention;Services;standard of care;study population;substance use;Substance Use Disorder;substance use treatment;Supervision;System;Technology;Testing;Time;tool;Translations;treatment services;trial comparing;Underserved Population;United States;uptake;Woman;Work;young adult

PROJECT_TITLE: Technology Enhanced Substance Use and HIV Service Navigation for Justice-Involved Young Adults

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: 8. PROJECT NARRATIVE Because there are no clear biomarkers for a cure for HIV – unlike CD4+ count and viral load as markers of the efficacy of antiretroviral therapy – people living with HIV in research are asked to pause their treatment to test the efficacy of potential HIV cure strategies. Moving forward, research teams will need to ensure that participants remain adequately informed and accepting of the clinical and psychosocial risks of pausing their treatment as part of HIV cure trials. We plan to investigate the quality of informed consent of participants in these trials, capture the psychosocial experiences of participants in these trials, and build and refine ethical considerations to help accelerate and expand promising HIV cure discoveries to populations carrying the greatest burden of HIV.

PI_NAMEs: DUBE, KARINE ;SAUCEDA, JOHN ANDREW (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Acceleration;Address;Affect;AIDS clinical trial group;antiretroviral therapy;Anxiety;anxiety states;Attention;Bioethics Consultants;Biological Markers;California;Caring;CD4 Lymphocyte Count;Clinical;Clinical Research;Color;Communication difficulty;Communities;community partners;Complex;Consensus;Consent;COVID-19 pandemic;Data;Decision Making;demographics;Development;early phase trial;efficacy evaluation;efficacy testing;Ensure;Ethical Analysis;Ethics;ethnic difference;Evaluation;expectation;experience;Expert Opinion;gender difference;Goals;HIV;HIV Infections;Hybrids;Informed Consent;International;Interruption;Interview;Knowledge;Measures;Medical;meetings;member;Monitor;novel;Outcome;Participant;patient safety;Persons;Population;Procedures;Process;prospective;psychologic;psychosocial;Psychosocial Factor;racial difference;Recommendation;Regrets;Reporting;Research;Research Personnel;resilience;Risk;risk mitigation;San Francisco;Sex Differences;Sexual Partners;social stigma;Stress;Surveys;Symptoms;Techniques;Testing;Therapeutic;therapeutic misconception;therapy resistant;Time;trait;transgender;transmission process;Treatment Efficacy;United States National Institutes of Health;Universities;Viral;Viral Load result;Viremia;Virus;Woman

PROJECT_TITLE: Investigating Psychosocial Experiences of HIV Cure Trial Participants Undergoing Extended HIV Treatment Interruptions: Implications for Ethical Conduct

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE This single-arm interventional trial seeks to evaluate the preliminary efficacy of menstrual cups on non-optimal vaginal microbiome (VMB), BV, and STIs of economically vulnerable women at high risk for STIs and HIV, assess safety profile, and understand implementation needs. Assessing preliminary efficacy signal in conjunction with implementation characteristics and adverse events, will generate a comprehensive and necessary foundation for definitive assessment of effectiveness of menstrual cups as a multipurpose intervention for MHM, and to reduce BV and STIs. This proposal advances global health and women’s reproductive health, as the knowledge gained will support future policy and guidelines on menstrual hygiene education and management, and integration with sexual and reproductive health care.

PI_NAMEs: MEHTA, SUPRIYA DINESH (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: 16 year old;Acceleration;Address;Adverse event;Age;aged;arm;Bacterial Vaginosis;Behavioral;biobehavior;Biological;Characteristics;Chlamydia;contextual factors;cost;cost effective;cost effective intervention;Counseling;COVID-19;Data;Decision Making;design;Detection;Discrimination;diverse data;Dryness;Education;effectiveness evaluation;Eligibility Determination;Epidemic;Extravasation;Financial Support;Focus Groups;Foundations;Future;General Population;girls;global health;Gonorrhea;Gossypium;Guidelines;Healthcare;High Risk Woman;HIV;HIV/STD;Hygiene;implementation context;implementation determinants;implementation evaluation;implementation framework;improved;Individual;Intervention;Intervention Trial;Interview;Investigation;Kenya;Knowledge;Lactobacillus;Life;Location;low and middle-income countries;Medical;Menstruation;microbiome composition;Odors;pandemic disease;Participant;pharmacovigilance;Phase;Policies;Porifera;Poverty;Practice Management;Prevalence;prevent;primary outcome;Privacy;programs;Randomized;Reporting;Reproductive Health;Research Personnel;Risk;Rural;Safety;safety assessment;Sanitation;scale up;Secondary Schools;Secrecy;sex;Sex Behavior;sexual and reproductive health;Sexual Partners;Signal Transduction;Soaps;social;social stigma;stem;Surveys;Taboo;Technology;Time;Training;treatment arm;trial design;Trichomonas Infections;UNESCO;Vagina;vaginal dryness;vaginal microbiome;Water;Woman;women's reproductive health;Wool;Work

PROJECT_TITLE: Single arm trial of menstrual cups among economically vulnerable women to reduce Bacterial vaginosis and STIs through reduced harmful sexual and menstrual practices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-E(02)]