NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

PHR: Project Narrative The 2024 Gordon Research Conference (GRC) and Seminar (GRS) on Immunometabolism in Health and Disease have highly interdisciplinary programs that bring together international experts, early-stage investigators, and trainees to discuss emerging concepts, approaches, and opportunities at the interface of cellular metabolism and innate and adaptive immunity. The research topics have been carefully selected to address both mechanistic roles for cellular metabolism in myeloid and lymphoid cells, and therapeutic implications of these functions in a wide variety of immune-mediated diseases (e.g., infectious disease, allergy, autoimmunity, cancer, atherosclerosis, obesity, and diabetes). Moreover, the Immunometabolism in Health and Disease GRC and GRS aims to foster interactions between academia and industry, and to help seed and cultivate the next generation of diverse scientists in this critical cross-disciplinary field.

PI_NAMEs: HEDRICK, CATHERINE C;RATHMELL, JEFFREY C. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Academia;Acceleration;adaptive immunity;Address;Aging;Allergic;Area;Atherosclerosis;Atmosphere;Autoimmunity;Bioenergetics;Cardiovascular Diseases;career;career development;catalyst;Cells;Cellular biology;Clinical;Collaborations;Communicable Diseases;Country;Development;Diabetes Mellitus;Disabled Persons;Discipline;Disease;Ensure;Equilibrium;Fostering;Goals;Health;Human;Hypersensitivity;Immune;immune function;Immune response;Immune System Diseases;Immunity;Immunology;immunoregulation;improved;Industrialization;Industry;Infection;Inflammation;Inflammatory Response;innovation;insight;interest;International;Intervention;Investigation;Learning;Lymphoid;Lymphoid Cell;Malignant Neoplasms;Mediating;meetings;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Pathway;Metabolism;Methods;microbiome;Minority;Minority Groups;Modeling;Myelogenous;Myeloid Cells;Natural Immunity;Nature;new therapeutic target;next generation;Obesity;Oral;Pharmacologic Substance;Productivity;programs;Research;Research Personnel;Resolution;Rhode Island;Role;Science;Scientist;sensor;Surveys;symposium;T-Lymphocyte;Technology;Therapeutic;therapeutic target;Time;Translating;translational potential;Translations;Travel;tumor immunology;tumor microenvironment;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: 2024 Immunometabolism in Health and Disease Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: RALEIGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: VETERINARY SCIENCES

ORG_FIPS: US

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the current management protocols for disseminated intravascular coagulation (DIC) focus on the underlying disease, rather than addressing coagulopathy, and result in staggeringly high mortality rates for both humans and animals. We have developed fibrin-specific nanogels (FSNs) that site-specifically deliver anti-clotting drugs while also enhancing fibrin cross-linking and formation, providing a solution for both the prothrombotic and hemorrhagic DIC phenotypes. Loading FSNs with both a fibrinolytic and an anticoagulant has the potential to provide an enhanced effect on improving DIC outcomes, with the potential of overcoming the limitations of current therapies and saving lives.

PI_NAMEs: LUTZ, HALLE  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute;Address;Adjuvant Therapy;Affect;Alteplase;Animal Disease Models;Animal Model;Animals;Antibodies;Anticoagulants;Biodistribution;Blood Coagulation Disorders;Blood Coagulation Factor;Blood Platelets;Bone Marrow;Bone Marrow Examination;Canis familiaris;Cardiovascular Diseases;Cell Communication;Cell model;Circulation;Clinical;Clinical Trials;Coagulation Process;Consumption;crosslink;Data;Death Rate;Deposition;Development;Disease;Disseminated Intravascular Coagulation;dosage;Dose;Drug Delivery Systems;effective therapy;emerging antimicrobial resistance;Endothelium;Environment;extracellular;Fibrin;Fibrin fragment D;Fibrinogen;Fibrinolysis;Fibrinolytic Agents;Freeze Drying;Functional disorder;Goals;Healthcare;Hemorrhage;Hemostatic function;Human;human disease;improved;In Vitro;in vivo;in vivo Model;Individual;Injury;Laboratories;Learning;Life Expectancy;Lipopolysaccharides;Malignant Neoplasms;Maximum Tolerated Dose;Mentorship;migration;Modeling;Morphology;mortality;N-isopropylacrylamide;NanoGel;Nature;neutrophil;North Carolina;novel;Organ;organ injury;Outcome;Pathologic Processes;Pathology;Pharmaceutical Preparations;Phenotype;Plasma;Platelet Count measurement;Pregnancy;Protocols documentation;Public Health;Rattus;Research;Resources;response;response to injury;Risk;Rodent Model;Role;Safety;Scientist;Sepsis;side effect;Site;skills;Spleen;Structure;Students;targeted delivery;targeted treatment;Testing;Thrombin;Thrombocytopenia;Thrombus;Training;Translational Research;translational scientist;Trauma;Treatment Protocols;Universities;Work

PROJECT_TITLE: Loaded Fibrin-Specific Nanogels for Sepsis-Induced DIC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Hearing loss, often resulting from cochlear sensory hair cell dysfunction, greatly impacts the quality of life for millions of people. We aim to understand the mechanisms that regulate the processing and localization of specialized auditory protein complexes in hair cells, and explore the impact of hearing-loss-related mutations on these processes. Our research is expected to reveal novel molecules and mechanistic checkpoints in hair cell protein processing, potentially offering new targets for therapeutic interventions to address hearing loss.

PI_NAMEs: CUNNINGHAM, CHRISTOPHER L (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Address;Affect;Auditory;Binding;Biochemistry;Biogenesis;Cells;Cochlea;Complex;Data;deaf;deafness;Defect;Disease;DNA Sequence Alteration;Endoplasmic Reticulum;Exclusion;Functional disorder;gene function;Genetic;Goals;Hair Cells;Hearing;hearing impairment;Hearing Tests;hereditary hearing loss;In Vitro;in vivo;Individual;innovation;insight;Integral Membrane Protein;Knowledge;Labyrinth;Life;Link;link protein;Mechanics;mechanotransduction;Mediating;Membrane;Methyltransferase;Molecular;Molecular Chaperones;mutant;Mutation;new therapeutic target;novel;Pattern;peroxisome;Persons;PHEX protein;Process;programs;protein complex;Proteins;Quality of life;Research;Role;Sensory;Sensory Hair;Signal Transduction;sound;Sound Localization;targeted treatment;Technology;Testing;Therapeutic Intervention;therapeutic target;trafficking;Work

PROJECT_TITLE: Processing and localization of the mechanotransduction channel subunit TMC1

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (47)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Neural tracking of natural speech provides an exciting new window into human communication abilities. However, many basic questions about what the neural tracking reflects, and how it could be utilized in the diagnosis and treatment of hearing disorders, remain unanswered. This project will characterize the cochlear, neural, and cognitive contributions to age- and hearing-loss-related changes in the perception and neural responses to speech.

PI_NAMEs: WOJTCZAK, MAGDALENA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Adult;Affect;Age;age difference;age effect;age related;age related decline;Auditory;Auditory Perception;auditory processing;behavioral study;Clinical;Cochlea;Cochlear Hearing Loss;Cognitive;cognitive function;Communication;Complex;Comprehension;Data;Data Analyses;Detection;Development;Diagnosis;diagnostic tool;Discrimination;Dissociation;Electroencephalography;Electrophysiology (science);experience;Future;Goals;Growth;Hearing;hearing impairment;Hearing problem;Human;improved;Individual;Individual Differences;Intervention;life span;Linguistics;Link;Masks;Measurement;Measures;Methods;neural;neural correlate;Neural Inhibition;Neurons;neurophysiology;noise perception;noninvasive diagnosis;normal hearing;older adult;Older Population;Outcome;Participant;Perception;Performance;Peripheral;Population;Presbycusis;public health relevance;rate of change;response;Role;Sampling Studies;Semantics;Signal Transduction;sound;Speech;speech in noise;Speech Intelligibility;Speech Perception;speech processing;speech recognition;Stimulus;successful intervention;Techniques;Testing;Validation

PROJECT_TITLE: Effects of age and hearing loss on auditory temporal processing: Perceptual and electrophysiological measures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed studies will provide novel insight into the biomechanical forces and regulatory processes that drive ovulation while simultaneously providing me with scientific and leadership skills to be a successful clinician- scientist. I propose that during ovulation, progesterone decreases expression of a calcium channel, TRPV4, which promotes fluid accumulation in the ovarian follicle and leads to a disproportionate increase in pressure on the region of the follicle wall that will rupture to release the cumulus oocyte complex. Quantifying the biomechanical forces and regulators that drive follicle rupture during ovulation will lead to improved understanding of anovulatory infertility and to the development of novel non-hormonal contraceptives.

PI_NAMEs: ZANIKER, EMILY  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;aging related;Alginates;Anovulation;anovulatory infertility;antagonist;Antral;Apical;Attention;Automobile Driving;Bioinformatics;Biology;Biomechanics;Calcium;Calcium Channel;career;Cations;Cells;Complex;Computer Models;Contraceptive Agents;Controlled Study;Cyst;Data;Development;Dimensions;Discipline;Down-Regulation;Encapsulated;Fertility;fluid flow;folliculogenesis;Goals;granulosa cell;Growth;Hour;Human;Human Chorionic Gonadotropin;Hydrogels;hypothalamic pituitary gonadal axis;Image;Immune;Impairment;improved;in vivo;Individual;Infertility;Infrastructure;inhibitor;insight;Ion Channel;Leadership;Lentivirus Vector;Liquid substance;Mammalian Oviducts;Mathematics;Measurement;Measures;member;Mentors;Messenger RNA;Microscopy;Mifepristone;Modeling;Molecular;Molecular Profiling;Mus;Nature;new technology;novel;Oocytes;Osmosis;Ovarian;Ovarian aging;Ovarian Follicle;Ovary;overexpression;Ovulation;Ovulation Induction;Pathology;Play;Polycystic Kidney Diseases;pressure;pressure sensor;Process;Progesterone;Progesterone Receptors;Proteins;receptor;receptor expression;reproductive;Reproductive Medicine;Reproductive Sciences;Research;Resolution;response;Role;Rupture;Scientist;Side;Site;skills;Smooth Muscle;Study models;Surface;Swelling;System;Testing;Thinness;Tissues;transcriptome;Translating;treatment strategy;TRP channel;Visualization;Work

PROJECT_TITLE: Follicle-Inherent Biomechanical Mechanisms Underlying Ovulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: Public Health Relevance Crimean-Congo hemorrhagic fever (CCHF), Thunderclap headaches, and Nairobi sheep disease, are dangerous emerging human and animal diseases caused by nairoviruses that can potentially cause widespread health and economic devastation. Recently, nairoviruses have been shown to share a conserved evasion mechanism that hinders the human innate immune response. This proposal serves to investigate and leverage that mechanism through synergetic molecular, cell based and in vivo means in order to will provide information for the development of selective and broad-based anti- viral treatments.

PI_NAMEs: PEGAN, SCOTT DUSAN (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Advanced Development;Africa;Animal Diseases;Anti-viral Response;Asia;Biochemical;Catalytic Domain;Cells;Central Asia;Chiroptera;Complex;Congo;Crimean Hemorrhagic Fever;Crimean-Congo Hemorrhagic Fever Virus;Dangerousness;Data;Death Rate;Development;Disease;Distress;Economics;efficacy evaluation;Elements;emerging human pathogen;Europe;Family;Fatality rate;FDA approved;Fever;Foundations;gene product;Genes;Genome;Glycoproteins;Goals;Health;Hemorrhage;Homologous Gene;Human;human disease;human pathogen;Immune Evasion;Immune system;Immunity;immunogenicity;Immunosuppression;improved;In Vitro;in vitro activity;in vivo;innate immune pathways;Innate Immune Response;insight;Interferons;Knowledge;Measures;Methods;Molecular;Mus;Nairobi Sheep Disease;Nairobi sheep disease virus;Nairovirus;Natural Immunity;ovarian neoplasm;particle;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Phylogenetic Analysis;Play;Post-Translational Protein Processing;preference;pressure;prophylactic;prostration;Protease Domain;Proteins;Proteomics;public health relevance;recruit;Replicon;Reporting;response;reverse genetics;Risk;RNA Viruses;RNA-Directed RNA Polymerase;Role;Route;Russia;Severities;Sheep;Source;Species Specificity;Specificity;Structure;System;Therapeutic;Thunderclap Headaches;tick-borne virus;Time;transmission process;Ubiquitin;ubiquitin isopeptidase;Ubiquitination;United States;vaccine candidate;Vaccines;Variant;vector tick;Vertebrates;Viral;Viral Hemorrhagic Fevers;Viral Proteins;Virulence;Virulence Factors;Virus;Virus Inactivation;Virus Replication;X-Ray Crystallography;Zoonoses

PROJECT_TITLE: Origin of the innate immunity suppression caused by nairovirus' protease activity

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE: Human cytomegalovirus is among the most common congenital infections and can cause severe, lifelong symptoms for a developing fetus. In this proposal, I aim to elucidate how placental trophoblast cells defend against HCMV infection and how these defenses could in turn drive placental dysfunction. Studies such as this are critical to understand how viruses and other pathogens can cross the placenta, gain access to the fetus, and ultimately cause congenital disease.

PI_NAMEs: HATTERSCHIDE, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Adult;Area;Biological Models;Bypass;Cell Physiology;cell type;Cells;Cellular biology;Circulation;congenital infection;CRISPR/Cas technology;Cytomegalovirus;Cytomegalovirus Infections;Data;Decidua;Development;Disease;Embryo;Facioscapulohumeral Muscular Dystrophy;Fellowship;fetal;Fetal Development;Fetal Growth Retardation;Fetus;Foundations;Functional disorder;Gene Expression;Genes;Genetic Engineering;Genetic Transcription;Goals;Herpesviridae;Hormone secretion;Human;human data;human model;Immunologics;Impairment;in utero;Infection;Intrinsic factor;Invaded;Kinetics;Knock-out;lytic replication;Maps;Maternal-Fetal Exchange;Mentors;Methods;Microbiology;Microcephaly;Modeling;Muscle Cells;Nature;Neurodevelopmental Impairment;novel;Organoids;overexpression;pathogen;Pathology;Pathway interactions;Physiology;Placenta;placental trophoblasts;postnatal;Pregnancy;Primary Cell Cultures;Refractory;Reporting;Research;Research Personnel;Resistance;response;RNA analysis;Scientist;Sensorineural Hearing Loss;single-cell RNA sequencing;skills;Species Specificity;Symptoms;Teratogens;Testing;Tissues;Training;transcription factor;transcriptome sequencing;trophoblast;Viral;Virus;Virus Diseases

PROJECT_TITLE: Defining cell-intrinsic trophoblast defenses to HCMV infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Despite effective antiretroviral therapy (ART), HIV resides in infected cells as integrated proviruses and persists lifelong. The source of HIV-induced immune activation remains obscure. We will use cutting-edge, state-of-the-art single-cell multi-omic profiling methods to examine HIV-induced chronic immune activation in people living with HIV under suppressive antiretroviral therapy.

PI_NAMEs: HO, YA-CHI  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: age acceleration;Anatomy;antiretroviral therapy;Blood;cancer risk;Cardiovascular Diseases;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Chronic;Clinical;Coupled;cytokine;DNA;Effector Cell;Enzymes;Epigenetic Process;exhaustion;Fire - disasters;Gene Expression;Genes;Genetic Transcription;genome-wide;Goals;Heterogeneity;HIV;HIV Infections;HIV-1;Immune;immune activation;immune clearance;Immune response;Immunity;in vivo;Individual;Inflammation;Measures;Membrane Proteins;Memory;Methods;multiple omics;Myeloid Cells;Natural Killer Cells;peripheral blood;Persons;Plasma;premature;programs;Proliferating;promoter;protein expression;Provirus Integration;Proviruses;Regulatory T-Lymphocyte;Research;Resolution;response;Risk;RNA;Source;T cell differentiation;T-Cell Activation;Testing;therapeutic target;Time;Tissues;transcriptome;transcriptomics;Validation;Viral;Viral Cytopathogenic Effect;Viral Genes;Viral Load result;Viral Proteins

PROJECT_TITLE: Understanding HIV-1 persistence and HIV-1-induced inflammation in tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunization;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative: The impact of limited drug delivery and immune evasion have rendered the aggressive and invasive brain cancer, glioblastoma (GBM), virtually uncurable with current therapeutic approaches. Therapeutic focused ultrasound (FUS) can safely deliver energy to the brain to reach a therapeutic threshold that results in a variety of bioeffects, including temporary blood brain barrier opening (BBBO) and activation of a local immune response. The goal of this proposal is to utilize advanced imaging approaches like PET-CT to study how FUS can be applied to improve the brain delivery and antitumor effects of anti-CD47 immunotherapy.

PI_NAMEs: MALLA, ADARSHA PRAKASH (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acoustics;Address;Adjuvant;angiogenesis;Animal Model;Animals;Anti-CD47;Antigen-Presenting Cells;antigen-specific T cells;Antigens;antitumor effect;Area;Biodistribution;Biological Products;Blood - brain barrier anatomy;Bone Marrow;Brain;Brain Neoplasms;Brain region;brain tissue;cancer cell;career development;Caring;CD47 gene;Cells;Cerebrum;chemotherapy;Clinical;clinical infrastructure;Clinical Trials;Clinical Trials Design;clinically relevant;contrast enhanced;Contrast Media;Cross Presentation;Cross-Priming;Data;Development;Development Plans;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Eating;Emerging Technologies;Evaluation;Excision;Exclusion;Extravasation;Focused Ultrasound;Focused Ultrasound Therapy;Future;Gases;Genetic Engineering;Glioblastoma;Goals;Human;Image;image guided;image guided intervention;imaging approach;Immune Evasion;Immune response;Immunocompetent;Immunologic Surveillance;ImmunoPET;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Infiltration;Infrastructure;insight;Intervention;intravenous administration;Invaded;Investigational Therapies;Lipids;Malignant neoplasm of brain;Maryland;Mediating;Methods;Microbubbles;Microglia;Modeling;Monoclonal Antibodies;multimodality;Mus;Nature;neoplastic cell;neuro-oncology;Neurologic;neurosurgery;novel;Operative Surgical Procedures;Patients;PET/CT scan;Phagocytes;Phagocytosis;Pharmaceutical Preparations;Physiological;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Primary Brain Neoplasms;Primary Neoplasm;Publishing;radiotracer;rational design;Recurrence;Reporting;Research;Research Project Grants;Residual Neoplasm;Residual state;safety and feasibility;Signal Transduction;Solid Neoplasm;standard of care;Surgically-Created Resection Cavity;temozolomide;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;Translating;tumor;tumor heterogeneity;Tumor Immunity;tumor-immune system interactions;ultrasound;uptake;virtual;Work

PROJECT_TITLE: ImmunoPET Evaluation of Focused Ultrasound-mediated Delivery and Immunomodulation by anti-CD47 Immunotherapy in the Setting of Current Standard-of-Care Treatment for Glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Rare Diseases

PHR: Project Narra�ve Infec�ons by the bacteria Vibrio cholerae cause the diarrheal disease cholera responsible for millions of cases annually. This proposal will address how the cells lining the intes�ne react to collapse of the cell architecture caused by a toxin produced by the bacterium. Understanding how cells of the intes�ne respond to structural collapse will provide key health insights into Vibrio cholerae infec�on and a greater understanding of general cellular regula�on.

PI_NAMEs: MILLS, JORI  (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Actins;Address;Adult;Architecture;Area;Automobile Driving;Award;Bacteria;Bacterial Toxins;Bacteriology;Binding;career;career preparation;Caspase;Cell Line;Cell membrane;Cells;Cellular Structures;chemokine;Cholera;Communicable Diseases;Communication;Core Facility;crosslink;Cytoplasm;Cytoskeleton;Darkness;Data;density;depolymerization;Detection;Development;diarrheal disease;Disease;Dissociation;Endoplasmic Reticulum;endoplasmic reticulum stress;Engineering;Environment;Enzymes;Epithelial Cells;Epithelium;Eukaryotic Cell;F-Actin;filamin;G Actin;Generations;Genes;Genetic;Goals;Grant;Health;Hydrolase;IL8 gene;Image;Immune Evasion;Immune response;in vivo;Infection;Inflammation;Inflammatory;inhibitor;Inositol;insight;Interleukins;JNK-activating protein kinase;Journals;JUN gene;knock-down;Link;Literature;Luciferases;Manuscripts;MAPK3 gene;MAPK8 gene;Mass Spectrum Analysis;medical schools;Mentorship;misfolded protein;Mission;Mitogen-Activated Protein Kinases;Mitogens;Modeling;Molecular;Monitor;monomer;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myosin Type II;National Institute of Allergy and Infectious Disease;Neutrophil Infiltration;non-muscle myosin;Nonmuscle Myosin Type IIA;Oranges;p38 Mitogen Activated Protein Kinase;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pattern;Phosphorylation;Phosphotransferases;Poverty;programs;Protease Domain;Proteins;Proteomics;Publishing;Reaction;Reporter;Research;response;rho GTP-Binding Proteins;Role;Science;sensor;Signal Transduction;Site;skills;small hairpin RNA;Small Interfering RNA;Small Intestines;Techniques;Testing;Toxin;trafficking;Training;transcription factor;Transcription Factor AP-1;Transfection;Universities;Vibrio cholerae;Vibrio cholerae infection;Viola;Vulnerable Populations;waterborne;Western Blotting;Work;Writing

PROJECT_TITLE: Host detection of Vibrio cholerae-induced actin damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Rare Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Cholestatic liver disease, such as primary sclerosing cholangitis (PSC), is a critical clinical problem associated with high morbidity and mortality but no available FDA-approved treatment due to the limited understanding of the pathogenic mechanisms. Noncoding RNAs, such as long noncoding RNAs (lncRNAs), circular RNA (circRNAs), and microRNA (miRNAs), are important regulators of various physiological and pathological processes. The focus of this application is to examine the role of lncRNAh19-mediated dysregulation of circRNAs (CircEdil3 &CircAff3) in cholestatic liver injury and further identify the underlying cellular/molecular mechanisms for developing potential diagnostic and therapeutic strategies for PSC.

PI_NAMEs: ZHOU, HUIPING ROSE (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Algorithms;Animal Model;Antigens;Bile Acids;bile duct;bile formation;Bioinformatics;Biological Process;Ceramides;Characteristics;cholangiocyte;Cholestasis;circular RNA;Clinical;clinical application;Code;Data;Diagnostic;Disease;Epidermal Growth Factor;Family member;FDA approved;Fibrosis;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;H19 gene;Hepatic;Hepatic Stellate Cell;High-Throughput RNA Sequencing;HMGB1 gene;Human;human disease;Human Genome;Impairment;Inflammation;Inflammatory;Injury;innovation;Kupffer Cells;Ligation;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Macrophage;mammalian genome;Mediating;Metabolism;MicroRNAs;MLLT2 gene;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel diagnostics;overexpression;Pathogenicity;Pathologic Processes;Pathway interactions;Patients;Pattern;Physiological Processes;Play;Porifera;primary sclerosing cholangitis;Proliferating;promoter;Proteins;Publishing;Reporting;RNA analysis;RNA-Binding Proteins;Role;Sampling;senescence;Sequence Analysis;Serum;Severities;Signal Pathway;single nucleus RNA-sequencing;Sphingolipids;Sphingosine;Sphingosine-1-Phosphate Receptor;stellate cell;Taurocholic Acid;Testing;Therapeutic;Tissues;transcriptome;transcriptome sequencing;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Circular RNAs in Cholestatic Liver Diseases

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Peripheral nerve injuries are common and debilitating conditions affecting more than one hundred thousand people annually in the US. Prognosis for recovery of severe nerve injuries is poor, as high-grade axonotmetic and neurotmetic injuries usually do not spontaneously recover. The overall goal of this study is to develop a new optical imaging approach to understand the processes associated with nerve degeneration in live animals.

PI_NAMEs: BEREZIN, MIKHAIL Y. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animals;Architecture;Axon;axon regeneration;axonal degeneration;Biology;Cell Culture Techniques;Characteristics;Clinical;Complex;confocal imaging;cyanine;Data;Development;Distal;Emotional Stress;Esthesia;Event;experimental study;Failure;flexibility;Fluorescence;fluorescence lifetime imaging;Future;Gatekeeping;Genetic;Goals;Growth;high resolution imaging;Hour;Human;Image;imaging approach;Imaging Device;imaging modality;imaging probe;imaging system;Implant;improved;improved outcome;In Vitro;in vivo;in vivo imaging;in vivo Model;Injury;intravital imaging;Investigation;Length;Libraries;Limb structure;Link;Maintenance;Measurement;Measures;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;Methods;Microscopy;migration;minimally invasive;Modality;Modeling;Molecular;Molecular Probes;Monitor;Morphology;Mus;Muscle;NAD+ Nucleosidase;Nerve;Nerve Degeneration;nerve injury;Nerve Regeneration;nerve repair;Nerve Tissue;nerve transection;neural;neuromuscular;Neuromuscular Junction;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;optical imaging;Optical reporter;Optics;Organ;Outcome;Pathway interactions;Patients;Peripheral nerve injury;Peripheral Nervous System;Peripheral Nervous System Diseases;Persistent pain;Persons;pharmacologic;physically handicapped;Positioning Attribute;Process;Prognosis;Recovery;Regenerative capacity;repaired;Reporter;Reporter Genes;Reporting;Resolution;Rodent;Role;sciatic nerve;sciatic nerve injury;senescence;Sensory;serial imaging;Site;Skin;small molecule;Sterility;System;temporal measurement;Therapeutic;Thinking;Time;time interval;Tissues;tool;Transgenic Mice;Transgenic Organisms;Traumatic Nerve Injury;Travel;two-photon;United States;Validation;virtual;Visualization;Wallerian Degeneration;Work

PROJECT_TITLE: In vivo Visualization of Delayed Wallerian Degeneration in Peripheral Nerve Injury

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The vertebrate retina comprises many microcircuits working together to process information necessary for us to navigate the visual world. Although we have a good understanding of some key circuits, many others remain elusive. This is because there has not been an opportunity to map all cells and their detailed connectivity within a retina. This project will enable labs to work collaboratively to generate a complete connectome of an adult mouse retina, a key model system for studying visual processing and for understanding how cellular and circuit perturbation, such as loss of photoreceptors and their connections, contribute to vision loss.

PI_NAMEs: WONG, RACHEL O (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acceleration;Adult;Biological Models;Blindness;cell type;Cells;Communities;connectome;Development;Face;Goals;image registration;intercellular communication;Maps;Mus;nanometer resolution;Nerve Fibers;Photoreceptors;Process;Retina;Scanning Electron Microscopy;Services;Synapses;Visual;visual processing;Work

PROJECT_TITLE: Intercellular Communication in Retinal Development


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Arrestins underlie critical neurobiological signaling cascades of clinical relevance like nociception and addiction. This project will examine the validity of utilizing the cannabinoid 2 receptor as a means of creating a tractable research platform for the structural characterization of molecular interactions required for arrestin recruitment. This will enable continuing development of arrestin biased, GPCR-targeted pharmaceuticals designed using nuclear magnetic resonance-based approaches to enable more efficacious pharmacological profiles.

PI_NAMEs: SHRIVER, THOMAS  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Affect;Anxiety;Arr2;arrestin 2;arrestin3;Arrestins;Aspartate;Behavior;Binding;Biochemical;Bioinformatics;Biological Assay;biophysical analysis;C-terminal;Cell Line;Cell Physiology;Clathrin;Clinical;clinically relevant;CNR2 gene;combinatorial;Communication;Communities;Complex;Coupling;Crystallography;Data;Dependence;design;Development;Disease;Drug Targeting;Electron Spin Resonance Spectroscopy;Endocytosis;Environment;Excision;experimental study;extracellular;Family;FDA approved;Fluorescence Polarization;Foundations;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Glass;Glutamates;graph theory;GTP-Binding Proteins;Human;Human body;human data;In Vitro;in vivo;Individual;insight;Kinetics;knock-down;Length;Ligands;Mediating;Membrane;Mental Depression;Methodology;mimetics;Molecular;Molecular Conformation;molecular dynamics;mood regulation;mutant;Mutation;Nature;Neurobiology;Nociception;novel;Nuclear Magnetic Resonance;Pathway interactions;Pattern;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phosphopeptides;Phosphorylated Peptide;Phosphorylation;Phosphotransferases;Phylogeny;Process;Proteins;receptor;receptor binding;recruit;Regulation;Relaxation;Research;Resolution;response;Role;Signal Pathway;Signal Transduction;Specificity;Structural Biologist;Structure;Study models;System;Tail;targeted treatment;Techniques;temporal measurement;Testing;Therapeutic;therapeutic development;Traction;Transducers;Translations;Transmembrane Domain;transmission process

PROJECT_TITLE: Entropic Redistribution Drives the GRK-Independent Binding of Arrestin 2 to the Cannabinoid 2 Receptor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (90)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Fundamental aging processes appear to be root-cause contributors to most of the disorders and diseases across the lifespan that account for the bulk of ill health, disability, and health costs. The goal of the nation-wide Translational Geroscience Network (TGN) is to rapidly accelerate translation of geroscience-guided lifestyle, nutritional, and drug interventions that target these fundamental aging processes from biological discovery and pre-clinical validation to testing in human subjects. Through its efforts in planning, facilitating, and coordinating these studies, the TGN has enormous potential to impact public health through delaying, preventing, alleviating, and treating multiple disorders and promoting healthspan, the period of life free of disability.

PI_NAMEs: KRITCHEVSKY, STEPHEN B.;KUCHEL, GEORGE A;PIGNOLO, ROBERT JOHN (contact);TCHKONIA, TAMARA

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Acceleration;Adult;age-related disease;aging mechanism;aging process;Anti-Inflammatory Agents;Aqueous Humor;Archives;Award;biobank;Biological Assay;Biological Process;Biometry;Biopsy;Blood;Body Fluids;Cancer Hospital;Cancer Survivor;Carpal Tunnel Syndrome;Child;Chronic;Clinic;Clinical;Clinical Research;Clip;cognitive function;Colorado;Connecticut;COVID-19 long hauler;Data;data management;Delirium;design;Development;diabetic;Diagnosis;Dietary Intervention;disability;Disease;Down's Syndrome;early-career faculty;Education;Electrocardiogram;Enrollment;Ensure;equity, diversity, and inclusion;Funding;Future;Geroscience;gerotherapeutic;Glioblastoma;Goals;Grant;Hair;Health;Health Care Costs;healthspan;HIV;Human;human subject;Image;Immune System Diseases;Infrastructure;innovation;Institution;Insulin Resistance;Intervention;Intervention Studies;Life;life span;Life Style;lifestyle intervention;Link;Macular degeneration;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical Records;meetings;Metformin;Methods;Michigan;microbiome;minimally invasive;Minnesota;mortality;Multiple Myeloma;Nail plate;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Nutritional;Observational Study;Organ;Organ Transplantation;Orthopedics;Outcome Measure;Peripheral Blood Mononuclear Cell;personalized approach;Pharmaceutical Preparations;Phase;Phenotype;Physical Function;Plasma;Population Heterogeneity;pre-clinical;prevent;primary sclerosing cholangitis;Public Health;Quality Control;Questionnaires;Recording of previous events;repository;Research;Research Design;Research Personnel;Resources;response;Saint Jude Children's Research Hospital;Saliva;Sample Size;Sampling;Sampling Studies;Science;Scientist;senolytics;senomorphic;Septicemia;Serum;Site;Skilled Nursing Facilities;skin ulcer;space travel;success;Swab;Synovial Fluid;targeted agent;Testing;Time;Training;Translating;translational study;Translations;Urine;vaccine response;Validation;Wisconsin;Work

PROJECT_TITLE: Translational Geroscience Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (J1)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Parental participation in the care of hospitalized children has many positive outcomes, including helping parents to develop confidence in caring for their children, but there are many barriers to parents’ participation. This study will help us to understand how social determinants of health unique to each family influence parental participation and parenting confidence among parents of children diagnosed with congenital heart defects. The study findings will provide important information that can be used to develop new ways to improve the health of children with congenital heart defects and their families.

PI_NAMEs: HARLOW, ASHLEIGH  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Address;Affect;Authorization documentation;barrier to care;base;Black race;care delivery;caregiving;Caring;Categories;Cessation of life;Characteristics;Child;Child Care;Child Development;Child Health;Child Rearing;Clinical;clinical practice;Communication;Communities;Complex;Congenital Abnormality;Congenital Heart Defects;Cross-Sectional Studies;Data;data integration;data modeling;Decision Making;Development;Diagnosis;Discrimination;disorder risk;Elements;Employment;empowerment;Environment;Equation;Equity;ethnic diversity;ethnic minority;Ethnic Origin;experience;Family;Family Characteristics;Family Demographies;family influence;family structure;family support;Future;Health;health belief;health care availability;health disparity;health inequalities;Health Personnel;Health Resources;Healthcare;Healthcare Activity;high risk;Home;hospital care;Hospitalized Child;Hospitals;improved;Incidence;Income;Individual;Inequity;Insurance;Intervention;Interview;Knowledge;Latinx;Length of Stay;Life;life span;Linguistics;Link;Medical;Medical Care Team;medication administration;Mental Health;Methods;minority children;Modeling;Morbidity - disease rate;mortality;mortality risk;Nature;neurodevelopment;Operative Surgical Procedures;Outcome;outcome disparities;Pain management;parental influence;parental role;Parents;Patients;Pediatric Hospitals;Perception;poor health outcome;Population;Population Heterogeneity;premature;preservation;Prevention;Process;Race;racial diversity;racial minority;Recommendation;Research;Resources;Role;Safety;social health determinants;social influence;Social Processes;Source;surgical risk;Transportation;transportation access;Trust;Weight Gain

PROJECT_TITLE: Influences Of Social Determinants Of Health And Parental Participation In Hospital Care On Development Of Parenting Confidence Among Parents Of Children With A Congenital Heart Defect

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GREENVILLE

ORG_NAME: EAST CAROLINA UNIVERSITY

PHR: Project Narrative: Spirochetes cause several serious diseases in humans and periplasmic flagellar motility is crucial for virulence by all pathogenic spirochetes. The novel studies outlined in this proposal are to delineate periplasmic flagellar assembly, orientation, bacterial morphology, and motility that are distinctive in the spirochetes. The virulence-associated flagellar structural proteins can lead to the development of a structure-based pharmacological agent to treat or prevent diseases caused by the spirochetes.

PI_NAMEs: LIU, JUN ;MOTALEB, MD A (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Architecture;Bacteria;base;Biochemical;Bioinformatics;Biological;Biology;Bite;Borrelia;Borrelia burgdorferi;Borrelia burgdorferi Group;Brain;Cardiac;cell assembly;Cells;Collagen;Complex;Cryo-electron tomography;Data;Dermal;Development;Disease;Distant;Drug Design;Escherichia coli;Flagella;Genetic;genetic manipulation;Goals;Grant;Heart;Homologous Gene;Human;Hypothetical Protein;Image;In Situ;insight;Ixodes;Joints;Knowledge;Leptospira;Leptospirosis;Lyme Arthritis;Lyme Disease;Mastigophora;migration;Modality;model organism;Molecular;Morphology;Motility;Motor;mutant;Nervous System Disorder;novel;novel therapeutic intervention;Order Spirochaetales;Organelles;pathogen;Pathogenesis;Pathogenicity;Patients;Penetration;Periodontal Diseases;periplasm;pharmacologic;Phenotype;Play;prevent;Prevention strategy;protein structure prediction;Proteins;Public Health;recruit;Reporting;Research;Resolution;Rest;Role;Rotation;Salmonella enterica;Solid;Structural Protein;Structure;Syphilis;Technology;Time;Tissues;Torque;transmission process;United States;Vector-transmitted infectious disease;Virulence

PROJECT_TITLE: Delineation of unique flagellar proteins in spirochetes

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Clinical Research;Disability Research;Hearing Loss;Infectious Diseases;Neurosciences;Otitis Media;Pediatric

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Otitis media with effusion (OME) is a common childhood condition that can have serious negative immediate and long-term consequences. Many of these consequences are likely related to the resulting hearing loss that OME can cause but characterizing that hearing loss is limited by challenges associated with behavioral audiometric testing in young children. The goal of this work is to improve the diagnosis and understanding of OME and its associated hearing loss, including the development of an objective and non-invasive automated estimate of that hearing loss, as well as determine how variations in OME and its related hearing loss impact binaural processing.

PI_NAMEs: MERCHANT, GABRIELLE RYAN (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Acoustics;Address;Affect;Age;Audiology;auditory deprivation;auditory processing;Auditory Threshold;behavior test;Behavioral;Binaural;Child;Childhood;childhood hearing loss;Clinic Visits;Clinical;clinical decision-making;Clinical Practice Guideline;Clinical Research;Complex;Computer Models;Conductive hearing loss;Contralateral;Data;Development;Diagnosis;diagnostic tool;Disease;Disparity;Drops;Ear;effusion;Environment;Equipoise;experience;Goals;Hearing;hearing impairment;Hearing Tests;Impairment;improved;Incidence;Individual Differences;individual variation;Knowledge;knowledge base;language processing;Length;long-term sequelae;Measures;Mechanics;middle ear;normal hearing;Operative Surgical Procedures;Otitis Media;Otitis Media with Effusion;Outcome;Population;Prognosis;prognostic value;Proxy;Recommendation;Research;Resolution;Risk;Risk Factors;sound;Speech;speech processing;Testing;Time;tool;Tube;underserved community;United States;Variant;Visit;Work

PROJECT_TITLE: Hearing Loss, Prognosis, and Long-Term Impact of Otitis Media with Effusion in Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (45)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Deficits in sensory processing are common in brain disorders, but the neural substrates of these deficits are poorly understood, and the treatments for them are limited. Evidence suggests that higher-order auditory processing is subject to modulation by dopamine signaling in the striatum—a process that may go awry in diseases like schizophrenia. The current study will combine genetic circuit manipulations with in vivo imaging and behavior to link activity in specific dopamine projections and the modulation of specific striatal neuron types to auditory perception deficits that may be relevant to psychiatric disease.

PI_NAMEs: ANAIR, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Agonist;Antipsychotic Agents;Area;Attenuated;Auditory;Auditory area;auditory discrimination;Auditory Hallucination;Auditory Perception;auditory processing;auditory stimulus;auditory thalamus;autism spectrum disorder;Automobile Driving;Basal Ganglia;base;Behavior;Biological Assay;Brain Diseases;Brain region;Capsaicin;Cations;cell type;Chicago;Code;Communication;Corpus striatum structure;Data Analyses;Decision Making;designer receptors exclusively activated by designer drugs;Disease;Dopamine;Dopamine D1 Receptor;Dopamine D2 Receptor;dopamine system;dopaminergic neuron;Educational process of instructing;Ensure;Environment;experimental study;Fellowship;field study;Frequencies;Genetic;genetic approach;genetic manipulation;Goals;Hyperactivity;Hypersensitivity;Image;Impairment;in vivo;in vivo imaging;Induced Neurons;Knockout Mice;Knowledge;Laboratories;Link;Literature;Locomotion;Measures;Mediating;Mental disorders;Mentorship;Microscope;Modeling;Monitor;Mus;Nervous System Disorder;neural;neural circuit;Neurons;novel therapeutic intervention;Output;outreach;Pathologic;Pathway interactions;Perception;Performance;Pharmacotherapy;Process;Psychoses;Reporting;Research;response;Rodent;Role;Schizophrenia;selective expression;Sensory;sensory neuroscience;Signal Transduction;sound;Structure;Substantia nigra structure;Symptoms;Synapses;Tail;targeted treatment;Techniques;Testing;tool;Training;translational neuroscience;transmission process;TRPV1 gene;undergraduate student;Universities;virus genetics;Work

PROJECT_TITLE: Determining the nigrostriatal circuit basis of false auditory perceptions.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative: HPV causes 5% of cancers worldwide including 30% of head and neck cancers. While the majority of HPV infections are cleared by the innate immune system, long-term infections, occurring when the virus evades the innate immune system, can result in the formation of cancer. Completion of the proposed studies will enhance our understanding of how and why HPV attenuates the cGAS/STING pathway, a key innate immune pathway in the detection of viral infections and DNA damage, specifically in head and neck cancers.

PI_NAMEs: TOBEY, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: anti-cancer research;Attenuated;attenuation;Automobile Driving;Binding;Cancerous;career;Cells;Chemicals;Clinical;Cytosol;Data;DNA;DNA copy number;DNA Damage;DNA Repair;ds-DNA;Enzymes;Exposure to;extracellular;Genome;Genomic DNA;Genomics;Golgi Apparatus;graduate school;Guanosine Triphosphate;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;HPV negative;HPV positive;HPV-High Risk;HPV-negative head and neck cancer;Human papilloma virus infection;human papilloma virus oncogene;Human Papillomavirus;immune clearance;Immunology;Infection;inhibitor;innate immune pathways;Innate Immune System;Interferon Type I;Interferons;keratinocyte;Knock-out;Length;Location;Malignant Neoplasms;Measures;Mitochondria;Mitochondrial DNA;Molecular;Nucleic Acid Binding;Nucleic Acids;Oncogenic Viruses;Oncoproteins;oral HPV-positive head and neck cancers;Papillomavirus Transforming Protein E6;Pathway interactions;Patients;Pattern;Phosphorylation;Production;Property;Protein Degradation Inhibition;Proteins;Recombinants;response;Role;Second Messenger Systems;Sexually Transmitted Diseases;Source;Stimulator of Interferon Genes;Testing;Tonsil;tool;Training;Training and Education;tumor;UBE3A gene;ubiquitin-protein ligase;Uncertainty;Viral;viral detection;viral DNA;virology;Virus;Virus Diseases;Work

PROJECT_TITLE: HPV Attenuation of the cGAS/STING Pathway

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Muscular Dystrophy;Orphan Drug;Palliative Care;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: CURI BIO INC

PHR: PROJECT NARRATIVE Gene therapies for the disease of contractile muscle are extraordinarily difficult to develop and have a track record of significant adverse effects during clinical trials, including patient death. We will develop an in vitro model of contractility using both human and murine cells that can be used to pre-clinically test these therapies in a way that can translate results from animal to human studies. We will also use the platform to assess the viability of a revolutionary novel genetic medicine for Duchenne muscular dystrophy.

PI_NAMEs: GEISSE, NICHOLAS ANDREW (contact)

PROGRAM_OFFICER_NAME: PITTENGER, STEVEN THEODORE

PROJECT_TERMS: Address;Adverse effects;Affect;animal data;Animal Model;Animal Testing;Animals;Biological;Biological Assay;biological systems;Biology;Calcium;canine model;Cell Line;Cells;Cessation of life;Clinic;Clinical;clinical trial in a dish;Clinical Trials;comparative efficacy;Complex;cost;CRISPR correction;Data;Dependovirus;design;Development;Disease;disease model;disease phenotype;Disease Progression;Dose;drug development;Duchenne muscular dystrophy;Dystrophin;Engineering;Enzyme-Linked Immunosorbent Assay;Ethical Issues;Exhibits;exon skipping;experience;Failure;Functional disorder;Gene Expression;gene therapy;Genes;Genetic Medicine;Heart failure;Human;Human Biology;human data;human disease;human induced pluripotent stem cells;human tissue;improved;In Vitro;in vitro Assay;in vitro Model;in vitro testing;Individual;induced pluripotent stem cell;Life;Link;male;Marketing;mdx mouse;Measurable;Measures;Medicine;Metabolism;Modeling;Morphology;mosaic;mouse model;Movement;Mus;Muscle;Muscle Contraction;Mutation;Myocardial dysfunction;Neuromuscular Diseases;Newborn Infant;novel;novel therapeutic intervention;novel therapeutics;organ on a chip;Palliative Care;Pathology;patient population;Patients;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Populations at Risk;pre-clinical;Pre-Clinical Model;Preclinical Testing;premature;prevent;Proteins;Recovery;Recovery of Function;Respiratory Failure;response;Safety;Scheme;screening;sildenafil;single molecule;Skeletal Muscle;skeletal muscle wasting;Small Business Innovation Research Grant;social;Source;Speed;stem cells;success;System;Testing;Therapeutic;Therapeutic Effect;Time;Tissue constructs;Tissue Model;transcriptome sequencing;Translating;translational study;Translations;Variant;Western Blotting;Work

PROJECT_TITLE: A cross-species preclinical platform to enhance the translation of new medicines


NIH_SPENDING_CATS: Complementary and Integrative Health;Genetics;Infectious Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Staphylococcus aureus can cause infections within nearly all tissues in a host and treatment of disease is complicated by antimicrobial resistance. Energy balance and metabolism are critical to S. aureus viability; yet we know little about how S. aureus adapts its metabolism to persist in diverse infection sites. This proposal will investigate the role of a lipoic acid transfer protein in promoting S. aureus metabolism and virulence, which has the potential to expand our knowledge of host-microbe interactions and open avenues for therapeutic intervention.

PI_NAMEs: WOODS, REGINALD A (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;acetyl phosphate;Affect;Antimicrobial Resistance;attenuation;Bacteremia;Bacteria;Base Pairing;Biological Assay;Blood;bone;Carbon;Cell division;Cessation of life;Citric Acid Cycle;cofactor;combat;comparative;Complement;Complex;Coupled;Coupling;Data;Disease;energy balance;Energy Metabolism;Enzymes;Generations;Genes;genetic approach;Glycolysis;Heart;Host Defense;host-microbe interactions;Human;In Vitro;Infection;Infectious Skin Diseases;insight;Ketoglutarate Dehydrogenase Complex;Knowledge;Laboratory Finding;Link;Lung;Measurement;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methods;Multienzyme Complexes;Mus;mutant;non-Native;Nutrient availability;Nutritional;Nutritional Requirements;Osteomyelitis;Oxygen;pathogen;Pathway interactions;Phenotype;Phosphate Acetyltransferase;Phosphotransferases;Pneumonia;Population;Positioning Attribute;Production;programs;promoter;Proteins;Proxy;Pyruvate;pyruvate dehydrogenase;Pyruvate Oxidase;Reverse Transcriptase Polymerase Chain Reaction;Role;Signal Transduction;Site;Skin;Staphylococcus aureus;Systemic infection;Therapeutic Intervention;Thioctic Acid;Tissues;Virulence;yeast two hybrid system

PROJECT_TITLE: Evaluating the role of a lipoic acid transfer protein in Staphylococcus aureus metabolism and virulence


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE It is estimated that more than 10 million people fall ill with tuberculosis (TB) ever year, but less than 7 million were diagnosed and linked to care in 2021. We will assess the overall effectiveness and implementation of a novel TB case finding intervention implemented in India during the post-treatment period and will develop a model to help target the intervention among high-risk households. Optimizing this intervention and bringing it to scale could result in substantial reductions in time to TB diagnosis and treatment, thereby improving patient outcomes and reducing transmission.

PI_NAMEs: COX, SAMYRA RODER (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Adoption;Adult;Aftercare;Calibration;career;Caring;case finding;Characteristics;Clinic;Clinical;cohort;comorbidity;comparison control;comparison intervention;cost effectiveness;Country;Data;Data Analyses;data portal;Data Reporting;Dedications;design;Development;Diagnosis;Discrimination;disorder control;Doctor of Philosophy;Effectiveness;effectiveness outcome;Eligibility Determination;Enrollment;Epidemiology;epidemiology study;Evaluation;falls;Fellowship;Goals;Government;high risk;high risk population;Home;Household;implementation evaluation;implementation outcomes;implementation research;implementation strategy;improved;Incidence;indexing;India;Individual;Infectious Disease Epidemiology;Infectious Diseases Research;Interruption;Intervention;intervention effect;Interview;Investigation;Link;Literature;Maintenance;Mentorship;Methods;model building;Modeling;novel;Parents;Participant;Patient-Focused Outcomes;Patients;Persons;Policies;predictive modeling;Preventive treatment;Public Health Schools;Qualitative Research;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recurrence;Regression Analysis;Reporting;Research Methodology;screening;screening guidelines;Series;Site;skills;standard of care;statistics;Structure;Symptoms;telephone delivery;Testing;Time;Training;Translating;transmission process;treatment duration;trend;Tuberculosis;Tuberculosis diagnosis;tuberculosis treatment;Validation;World Health Organization

PROJECT_TITLE: Optimizing Post-treatment Household Contact Investigation for Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Biotechnology;Kidney Disease

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Nephrotoxic drug-induced kidney injury effects millions globally each year, leading to massive individual patient and widely national socio-economic burden. In this injury setting, endothelial cells have been hypothesized to transdifferentiate to a fibrotic phenotype through a mechanism known as endothelial to mesenchymal transition (EndMT). This proposal aims to understand the maturity of endothelial cells within a novel in vitro kidney model, while also further understanding the molecular and cellular mechanism of EndMT.

PI_NAMEs: MAGGIORE, JOSEPH COLE (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 3-Dimensional;Actins;Acute Renal Failure with Renal Papillary Necrosis;Address;Adherent Culture;Adopted;Animals;Career Choice;CD31 Antigens;Cell Communication;cell injury;Cell Line;Cell Maturation;cell type;Cells;Chronic;Chronic Kidney Failure;Cicatrix;Clinical;clinically relevant;Coculture Techniques;Complex;Data;Data Set;Development;Disease;Disease Pathway;Doxorubicin;drug discovery;Drug Exposure;Drug usage;Economic Burden;Electron Microscopy;Endothelial Cells;Endothelium;Engineering;Epithelial Cells;Epithelium;Event;Fibroblasts;Fibrosis;Flow Cytometry;Future;Glycocalyx;Goals;Hospitals;Human;Image;Immunofluorescence Immunologic;In Vitro;in vitro Model;in vivo;Individual;individual patient;induced pluripotent stem cell;inhibitor;injured;Injury;Injury to Kidney;innovation;Kidney;Kidney Diseases;Knowledge;Literature;Mesenchymal;Methods;migration;Modeling;Molecular;monolayer;Morphology;Myofibroblast;Nephrons;nephrotoxicity;novel;Nuclear RNA;Organ;Organoids;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phenotype;Play;podocyte;Population;Predisposition;Process;Publishing;Reproducibility;Research;Role;Sampling;Scanning Electron Microscopy;Scientist;Signal Transduction;single nucleus RNA-sequencing;Smooth Muscle;socioeconomics;spatiotemporal;Specificity;Study models;System;targeted treatment;therapeutic development;Tissue Engineering;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;transdifferentiation;Transgenic Organisms;Transmission Electron Microscopy;Tubular formation;Vascularization;Vasculogenic;Western Blotting;Work

PROJECT_TITLE: Understanding Kidney Endothelial Maturity and Mesenchymal Transition in Vascularized Human Kidney Organoids

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Kidney, Urology, and Hematology[DDK-G]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: NARRATIVE Neuroendocrine prostate cancer (NEPC) is an aggressive, androgen-independent subtype that most commonly manifests in the later phase of castrate-resistant prostate cancer and is associated with treatment resistance. The goal of this proposal is to develop a novel theranostic CAR-T cell paradigm that will allow for the successful targeting of antigen-heterogeneous NEPC under image guidance.

PI_NAMEs: PONOMAREV, VLADIMIR  (contact);SCHODER, HEIKO

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;Adenocarcinoma;advanced prostate cancer;androgen independent prostate cancer;Androgens;Animal Experiments;animal tissue;Antigen Targeting;Antigens;Apoptosis;bioluminescence imaging;Biopsy;cancer cell;Cancer Patient;CAR T cell therapy;Castration;Cell surface;chemotherapy;chimeric antigen receptor T cells;Clinic;Clinical;clinical application;clinical imaging;clinical translation;Clinical Trials Design;Data;design;Disease;Disease Progression;Disease Resistance;efficacy evaluation;engineered T cells;Exhibits;experimental study;FOLH1 gene;Future;Gene Modified;Genetic Engineering;Goals;Hematologic Neoplasms;Heterogeneity;hormone therapy;Image;image guided;imaging probe;Immunoconjugates;Immunotherapeutic agent;Immunotherapy;Institution;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;Mesothelioma;Monitor;Monoclonal Antibodies;Motivation;Neoplasm Metastasis;neoplastic cell;Neuroendocrine Prostate Cancer;Neurosecretory Systems;new therapeutic target;non-invasive imaging;non-invasive monitor;novel;Outcome;Patients;Pharmaceutical Preparations;Phase;pilot trial;Platinum;Positron-Emission Tomography;preclinical study;Prevention;Prostate;prostate cancer model;Prostate Cancer therapy;Protocols documentation;radiotracer;Reporter;Research;Resistance;response;Series;Site;Small Cell Carcinoma;Solid Neoplasm;success;Surface Antigens;T cell therapy;T-Cell Development;T-Lymphocyte;targeted treatment;Techniques;Technology;Testing;theranostics;Therapeutic;Therapeutic Effect;therapy development;therapy resistant;Time;Tissues;Tracer;trafficking;Translating;translational approach;Translations;Treatment Efficacy;tumor;tumor eradication;Tumor Escape;Tumor Tissue

PROJECT_TITLE: Theranostic DLL3/PSMA-bi-specific CAR-T cells for prostate cancer therapy

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Genetics

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Macrophages’ precise regulation of inflammation is vital in maintaining homeostasis and preventing excessive or insufficient inflammation observed in critical illnesses like sepsis, affecting 1.7 million US adults annually. One method of control is endotoxin tolerance, which is the ability for a secondary innate immune response to be diminished to prevent a hyperinflammatory or persistent response upon repeated exposure to endotoxins. This project aims to investigate the role of dynamic macrophage metabolism reprogramming in modulating the inflammatory response during endotoxin tolerance, potentially uncovering novel metabolic targets for managing critical illnesses such as sepsis and promoting human health.

PI_NAMEs: ARP, NICHOLAS LAWRENCE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetylation;Adult;Affect;Body Temperature;career;Cell Line;Cell Physiology;Cells;ChIP-seq;Chronic;Clinical;clinical phenotype;Coenzyme A Ligases;Communication;Critical Illness;cytokine;Data;Data Set;Endotoxins;Enzyme-Linked Immunosorbent Assay;Epigenetic Process;epigenome;Exposure to;Family member;fighting;Foundations;Gene Expression;Genetic;genome-wide;Global Change;Goals;Health;Histone Acetylation;histone modification;Histones;Homeostasis;Human;Immune;Immunology;Immunosuppression;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Innate Immune Response;insight;Interferon Type II;Intraperitoneal Injections;Knock-out;Knowledge;Lipopolysaccharides;Literature;Lysine;Macrophage;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methods;Modeling;Monitor;mouse model;Mus;Myelogenous;new therapeutic target;Nitric Oxide;Nitric Oxide Synthase;non-histone protein;novel;Phase;Physicians;Play;Post-Translational Protein Processing;prevent;Primary Cell Cultures;Process;Production;programs;Protein Acetylation;Proteins;Proteome;Pyruvate;pyruvate carrier;Pyruvate Dehydrogenase Complex;Regulation;Research;Research Institute;response;Role;Scientist;Sepsis;Serum;Severities;Site;skills;Supplementation;Testing;therapeutic target;Time;Training;Universities;Western Blotting;Wisconsin;Work

PROJECT_TITLE: Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Polycystic kidney disease (PKD) is the most common inheritable form of renal disease and affects 1 in 1000 individuals. Mutations in polycystin genes cause the formation of kidney cysts for which there is no cure, resulting in renal failure and the need for transplantation. This proposal will apply a novel scientific approach to understand polycystin dysregulation by relevant disease-causing mutations reported in patients.

PI_NAMEs: ESARTE PALOMERO, ORHI  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Asparagine;Autosomal Dominant Polycystic Kidney;Biochemical;biochemical tools;Biological Assay;Biophysics;Calnexin;career;career development;Cells;Cilia;ciliopathy;Classification;Complex;Consumption;Cryoelectron Microscopy;Cyst;Cystic kidney;design;Development;Dialysis procedure;Disease;disease-causing mutation;Doctor of Philosophy;Electrophysiology (science);Embryonic Development;empowerment;experience;Fellowship;Fertilization;Fluorescence;Functional disorder;Funding;Gene Mutation;Genes;Glutamine;glycosylation;Goals;Human;In Situ;Individual;Inherited;innovation;insight;Ion Channel;Ion Channel Gating;Kidney;kidney cell;Kidney Diseases;Kidney Failure;Kidney Transplantation;Kinetics;Leadership;Ligands;light scattering;Lighting;Lipid Bilayers;Lipids;Liposomes;Membrane;Membrane Proteins;Mentors;Methodology;Methods;microscopic imaging;Microscopy;middle age;Molecular;Molecular Sieve Chromatography;Monitor;mutant;Mutation;Nomenclature;novel;Optics;Organelles;Outcome;particle;Patients;Pharmaceutical Preparations;PKD1 gene;PKD2 gene;Play;Polycystic Kidney Diseases;Positioning Attribute;programs;Proline;Property;Protein Biochemistry;Protein Biosynthesis;Proteins;reconstitution;Regulation;Reporter;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Training;Resolution;Role;Scientist;sensor;skills;Stimulus;structural biology;Structure;superresolution imaging;superresolution microscopy;synthetic biology;System;Techniques;Time;trafficking;Training;Transplantation;ultra high resolution;Variant;Vesicle;voltage

PROJECT_TITLE: Polycystin glycosylation regulation and dysregulation in ADPKD


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: PROJECT NARRATIVE Though accelerated aging is robustly correlated with health and well-being during adulthood, little research has examined it’s predictive and functional relevance during early childhood. This study seeks to examine accelerated aging as a predictive pathway to explain how early life stress impacts children’s behavioral and cognitive functioning. This project will additionally elucidate the association between accelerated aging and children’s observed behavioral regulation and cognition during the first few years of life.

PI_NAMEs: SPERBER, JESSICA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Academic skills;Adult;Adverse event;adverse outcome;Age;age acceleration;Age Months;Behavior;behavior prediction;Behavioral;Biological;biological adaptation to stress;biological age;Biological Aging;Biological Markers;biological systems;biomarker identification;Birth;Brain;Child;Child Behavior;Child Development;Childhood;Chronic Disease;Chronic stress;Chronology;Cognition;Cognitive;cognitive development;cognitive function;cohort;college;COVID-19 pandemic;COVID-19 pandemic effects;Development;developmental psychology;DNA Methylation;early childhood;early experience;early life stress;Education;Enrollment;Epigenetic age;epigenetic aging;Epigenetic Process;executive function;experience;Experimental Designs;Exposure to;Family;Funding;Gene Expression;Gene Silencing;Genetic Transcription;genome-wide;Goals;Hair;Health;Hydrocortisone;improved;indexing;Individual;Infant;Inflammation;innovation;Institution;Interdisciplinary Study;interest;Language;Life;life span;Link;Literature;maternal stress;Measures;Mediating;Memory;Mental Health;Methodology;Methods;Modeling;Modification;mortality risk;Mothers;multimodality;National Institute of Child Health and Human Development;National Research Service Awards;Natural experiment;Neurosciences;New York City;novel;offspring;Outcome;pandemic disease;Parents;Pathway interactions;Pattern;perceived stress;Performance;Personal Satisfaction;physical conditioning;Physiological;postnatal period;Pregnancy;prenatal;prenatal exposure;Prevention;Problem behavior;Protocols documentation;psychological distress;Psychology;Psychopathology;Publishing;Recovery;recruit;Regulation;Reporting;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;saliva sample;Sampling;SARS-CoV-2 exposure;Science;Shapes;Skin;socioeconomics;Stress;Surveys;System;teacher;Testing;Texas;Therapeutic;Third Pregnancy Trimester;Training;Universities;Work

PROJECT_TITLE: Associations among maternal stress, infant epigenetics, and behavioral and cognitive development across the first few years of life

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Infertility;Pain Research;Prevention;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE This proposal aims to compare structural and functional features of the uterotubal junction in women with and without endometriosis, and to develop a miniature minimally invasive endoscope for endometriosis diagnosis. This work could profoundly advance our current understanding of an important yet critically understudied segment of female anatomy and identify microstructural features that can be used towards endometriosis diagnosis. The endoscope has potential to reduce the burden of undiagnosed endometriosis, enabling early and accurate diagnosis of endometriosis, timely treatment, and improved health outcomes.

PI_NAMEs: LONG, DILARA  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;accurate diagnostics;Address;Affect;aged;Algorithms;Anatomy;Animals;Architecture;Area;Biological Markers;Cannulations;Characteristics;Chronic;chronic pain;chronic pelvic pain;Cilia;Clinical;Collaborations;Collagen;Comparative Study;cost;Data;design;design,build,test;Detection;Devices;Diagnosis;Diagnostic Procedure;diagnostic value;Diameter;Disease;Disease Progression;Dysmenorrhea;Dyspareunia;Early Diagnosis;endometriosis;Endoscopes;Endoscopy;experience;feasibility testing;Female;female reproductive tract;flexibility;Frequencies;Functional impairment;functional status;Goals;Health;high resolution imaging;Histology;Human;Image;image processing;imaging modality;Imaging Techniques;Impairment;improved;in vivo;Individual;Infertility;interest;Laparoscopic Surgical Procedures;Letters;Malignant Neoplasms;Mammalian Oviducts;Maps;Measures;Methods;minimally invasive;Monitor;Morphology;Movement;Mus;Muscle;Muscle Contraction;non-invasive imaging;Normal tissue morphology;novel;novel strategies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Organ;Outcome;Pathogenesis;Patients;personalized medicine;Predisposition;Prognostic Marker;reproductive;Research;Resolution;Retrograde Menstruation;Risk;Role;Scanning;Smooth Muscle;Staging;Structure;subfertility;Surface;Symptoms;System;Systemic disease;Technology;Testing;Texture;Tissues;Uterus;Visualization;Woman;Work

PROJECT_TITLE: Imaging the Uterotubal Junction for Endometriosis Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Emergency Care;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There are more than 130 million emergency department visits in the U.S. each year, and many emergencies involve injuries and illnesses related to the brain, including stroke, seizures, traumatic brain injury, spinal cord injury, pain, addiction, and neurodegenerative diseases. To help advance research in these areas, this national Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS) aims to increase the number of emergency medicine clinician-scientists conducting successful and transformative research on neurologic (i.e., brain) disorders. To achieve this, we will identify, recruit, and support promising emergency medicine researchers at the beginning of their careers and ensure they have the time, mentorship, and training needed to effectively perform research that can improve the care of patients with neurologic disorders in the emergency department.

PI_NAMEs: ADEOYE, OPEOLU M;CALLAWAY, CLIFTON W.;D'ONOFRIO, GAIL ;NEUMAR, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Accident and Emergency department;Advisory Committees;Award;Basic Science;career;career development;clinical practice;Clinical Services;cohort;Country;Dedications;Doctor of Philosophy;Emergency Medicine;Ensure;experience;Faculty;Fellowship;Financial Support;Funding;Goals;Health Services;Home;Hospital Departments;Individual;Institution;medical specialties;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Michigan;Nervous System Disorder;Neurologic;next generation;Patients;Persons;Phase;Physicians;Program Development;programs;Qualifying;Records;recruit;Research;research and development;Research Personnel;Research Training;Residencies;Science;Scientist;Site Visit;Time;Training;United States National Institutes of Health;Universities;virtual;Washington;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-B (03)]


NIH_SPENDING_CATS: Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Neurodevelopmental disorders can be driven by primary defects in neurons or as secondary effects from al- tered formation of neighboring tissue such as the meninges or skull. Neurodevelopmental disorders can cause lifelong cognitive and motor impairments and uncovering their underlying mechanisms is important for develop- ing therapeutics. This proposal investigates development of the meninges, a protective covering for the CNS, to better understand why alterations in its formation impacts brain development.

PI_NAMEs: SIEGENTHALER, JULIE  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Arachnoid mater;Blood;Blood Vessels;bone;Bone Development;Bone Growth;Brain;brain abnormalities;brain overgrowth;Calvaria;cell motility;Cell secretion;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Cephalic;Cerebrospinal Fluid;cerebrovascular;Cerebrum;Cleavage Under Targets and Release Using Nuclease;clinically relevant;conditional mutant;Craniosynostosis;cranium;Data;Defect;Development;developmental disease;Disease;DNA Binding;Dorsal;Dura Mater;Dysplasia;Endothelial Cells;Etiology;Excision;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;fetal;Fetal Development;Fibroblasts;FOXC1 gene;FOXC2 gene;Genes;Genetic Transcription;Goals;Growth;Histologic;Homologous Gene;Human;Immune;Immunologic Surveillance;Impaired cognition;Impairment;Infection;insight;Intellectual functioning disability;Knowledge;Life;Ligands;Link;Lymphatic;Lymphatic System;Macrophage;Macrophage Colony-Stimulating Factor;Maintenance;Mediating;Meningeal;Meninges;migration;Modeling;Molecular;motor impairment;mouse model;multiple omics;Mus;mutant;Mutant Strains Mice;Mutation;Myofibroblast;nervous system development;Neurodevelopmental Disorder;neurogenesis;Neuroimmune;neuroinflammation;Neurons;Osteoblasts;osteogenic;paracrine;Paracrine Communication;pathogen;Pathway interactions;Peripheral;prenatal;Primordium;Production;Prosencephalon;Publishing;Regulation;response;Risk;Role;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Site;Source;Specific qualifier value;Structure;Surgical sutures;Testing;Therapeutic;Tissues;transcription factor;Viral;wasting

PROJECT_TITLE: CNS Fibroblast Formation and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (02)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Neurosciences

PHR: Project Narrative The objective of this project is to identify and model networks involved in processing tactile information in the ventral nerve cord of the fly, Drosophila melanogaster. This research will shed light on how different types of neurons support the fly’s ability to respond to tactile stimulation from different areas on the leg. Insights from this project will expand our understanding of how the nervous system organizes sensory information and may direct future research on how deficits in this tactile circuit may impact behavior.

PI_NAMEs: ELABBADY, LEILA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: 3-Dimensional;Affect;Afferent Neurons;Anatomy;Animals;Ankle;Ants;Architecture;Area;Axon;Behavior;behavior prediction;Behavioral;Biological Models;Caenorhabditis elegans;cell type;Cells;Chest;Computer software;connectome;Data;Development;Drosophila genus;Drosophila melanogaster;Electron Microscopy;Electrophysiology (science);Exhibits;experimental study;Fire - disasters;flexibility;fly;foot;Genetic;genetic approach;Grooming;Hand;imaginal disc;Individual;information processing;insight;Interneurons;Invertebrates;Knee;Label;Larva;Leeches;Leg;Limb structure;Maps;Mediating;microscopic imaging;Modeling;Morphology;Motor;Motor output;Movement;Nerve;Nervous System;network models;neural;neural circuit;Neurons;optogenetics;Outcome Study;Output;Pathway interactions;Pattern;Perception;Physiological;Poaceae;Proprioception;receptive field;Research;Resolution;response;Sampling;Sensory;sensory input;Shapes;Signal Transduction;Site;somatosensory;spatial integration;Stimulus;Structure;Synapses;System;Tactile;tactile stimulation;Techniques;Testing;Theoretical model;tool;Touch sensation;Variant;Walking

PROJECT_TITLE: Mapping and Modeling the Spatial Topography of Tactile Neural Circuits in Drosophila


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PUBLIC HEALTH NARRATIVE People living with HIV on antiretroviral therapy (ART) retain low levels of virus within cells and are not fully cured of HIV, remaining at higher risk for pulmonary infections such as pneumonia and tuberculosis than those without HIV. We propose to understand how the lung compartment of those with HIV contributes to both the persistence of HIV and dysfunctional immune responses in order to provide new insights towards better therapies for people with HIV.

PI_NAMEs: KIM, BAEK ;RENGARAJAN, JYOTHI  (contact);STAITIEH, BASHAR SAMIH

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Alveolar Macrophages;antiretroviral therapy;Automobile Driving;Bacterial Pneumonia;Bioenergetics;Biological Assay;Brain;Bronchoalveolar Lavage;Bronchoscopy;CD4 Lymphocyte Count;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Clinical;clinically relevant;co-infection;Data;Dendritic Cells;DNA;eosinophil;experience;Flow Cytometry;Genetic Transcription;Health;Health system;high risk;HIV;HIV Infections;Human;human tissue;Immune;immune activation;Immune response;Immune System Diseases;Immunologics;Immunology;Impairment;in vitro Model;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;insight;Interferons;latent HIV reservoir;life span;Lung;Lung infections;Macrophage;Male Genital Organs;Mediating;memory CD4 T lymphocyte;Metabolism;Mitochondria;monocyte;multidisciplinary;Mycobacterium tuberculosis;Natural Killer Cells;neutrophil;new therapeutic target;Oxidative Stress;pathogen;pathogenic bacteria;Pathway interactions;Persons;Phenotype;Pneumonia;Predisposition;Proteins;Proviruses;Public Health;Publishing;Pulmonology;reconstitution;recruit;Reporting;reproductive tract;Research;Residual state;respiratory pathogen;Respiratory Tract Infections;responders and non-responders;response;RNA;Role;Signal Pathway;Signal Transduction;Streptococcus pneumoniae;T cell response;T-Lymphocyte;Technology;Testing;TNF gene;transcriptome;transcriptomics;treatment responders;Tuberculosis;Viral Proteins;viral rebound;virology;Virus

PROJECT_TITLE: Investigating alveolar macrophages in PLWH as targets for HIV persistence, residual inflammation and immune activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (J1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases;Vaccine Related

PHR: PROJECT NARRATIVE Pancreatic ductal adenocarcinoma is a highly deadly cancer with the potential for improved outcomes in patient survival using combination immunotherapies. This research seeks to investigate the mechanisms of how these therapies alter the communication between immune cells to recognize and fight this cancer. Understanding these mechanisms will result in better treatments that utilize the immune system to eradicate cancer and lead to fewer deaths from this disease.

PI_NAMEs: MITCHELL, JACOB THOMAS (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adjuvant Study;Algorithms;Allogenic;anti-PD1 antibodies;anti-tumor immune response;Antibodies;Atlases;cancer cell;cancer infiltrating T cells;Cancer Vaccines;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Line;Cell Physiology;Cells;Cessation of life;Characteristics;checkpoint therapy;Clinical Data;Clinical Treatment;Clinical Trials;Combination immunotherapy;Communication;Communities;comparative;Complex;Computer software;computerized tools;Computing Methodologies;Cyclophosphamide;cytotoxic;cytotoxic CD8 T cells;cytotoxicity;Data;Development;Disease;Drug Targeting;exhaust;exhaustion;experimental study;fighting;Flow Cytometry;Future;Generations;Goals;Grant;GVAX Cancer Vaccine;Human;human disease;Hybrids;Immune;Immune checkpoint inhibitor;Immune response;Immune system;Immunosuppression;Immunotherapy;immunotherapy clinical trials;improved;improved outcome;Inflammatory;Intervention;Invaded;Investigation;Knowledge;Ligands;Macrophage;Maintenance;Malignant Neoplasms;member;Metastatic Neoplasm to the Liver;Methods;Modality;Modeling;Molecular;mouse model;Mutation;Myeloid Cells;Neoadjuvant Therapy;neoantigen vaccine;neoantigens;Neoplasm Metastasis;Nivolumab;novel;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathway Analysis;Patients;Pharmaceutical Preparations;Phenotype;Primary Neoplasm;Process;receptor;Research;response;Sampling;Signal Transduction;single-cell RNA sequencing;Statistical Methods;subcutaneous;success;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic vaccine;tool;treatment arm;treatment group;tumor;Tumor Cell Invasion;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;United States;vaccine response;Vaccines;Validation;Work

PROJECT_TITLE: Investigation of Immunotherapy-induced Alterations to Cellular Communication Networks in Pancreatic Ductal Adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Fetal Alcohol Spectrum Disorders (FASD);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Social Determinants of Health;Substance Misuse

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE Fetal alcohol spectrum disorders (FASD) affect 2-5% of the school-aged population, with up to 90% of individuals meeting criteria for a co-occurring mental health disorder. Yet, not a single mental health intervention has been developed for this population. The current project will adapt Dialectical Behavior Therapy for Adolescents (DBT-A) for individuals with FASD and conduct a feasibility trial of these adaptations in a community mental health clinic utilizing an implementation science framework.

PI_NAMEs: ROCKHOLD, MADELINE NICOLLE (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Administrator;Adolescent;Affect;Area;Attention;Award;Awareness;behavior change;Biological;care systems;career;Caregivers;Certification;Clinic;Cognitive Therapy;cohort;Communities;community advisory board;Competence;Country;Development;Dialectical behavior therapy;Dissemination and Implementation;dual diagnosis;emotion dysregulation;emotion regulation;Environment;Evaluation;evidence base;Evidence based treatment;executive function;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Feasibility Studies;feasibility testing;feasibility trial;Feedback;Feeling suicidal;Fetal Alcohol Spectrum Disorder;Future;Health Personnel;Home;implementation determinants;implementation facilitators;implementation framework;implementation science;improved;Individual;Intervention;Link;meetings;member;Memory;Mental disorders;Mental Health;Mental Health Services;mental training;Mentors;Methodology;Modality;Needs Assessment;Neurodevelopmental Disability;New York;Outcome;Persons;Population;post intervention;Predisposition;primary caregiver;Process;programs;Protocols documentation;Psychology;Randomized, Controlled Trials;Research;Research Design;Research Personnel;School-Age Population;skills;social health determinants;social stigma;Suicide attempt;Surveys;Symptoms;System;telephone coaching;Testing;therapy development;tool;Training;trauma symptom;treatment program;Underserved Population;Work

PROJECT_TITLE: Improving Mental Health Outcomes for Fetal Alcohol Spectrum Disorder: Tailoring Dialectical Behavior Therapy for Adolescents in a Community Mental Health Clinic

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Kidney Disease;Mental Health;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Relevance: Our long-term goal is to develop community-based, behavioral interventions to prevent age-related cognitive decline and ADRD in at risk populations across the lifespan. This study addresses a critical gap in our understanding of the use of exercise in the prevention and treatment of accelerated age-related cognitive decline in older adults with CKD and mild cognitive impairment. By combining cognitive function assessment with MR-imaging, we will be able to evaluate the brain-behavior response to exercise and discern the relationships at a level previously not conducted in this population and thus, the potential clinical impact is high and readily translatable.

PI_NAMEs: BRONAS, ULF G (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adherence;adherence rate;Affect;Age;age acceleration;Age-associated memory impairment;Alzheimer's disease related dementia;Alzheimer's disease risk;Anisotropy;arterial spin labeling;Atrophic;Attention;attentional control;Attenuated;Behavior Therapy;behavioral response;blood perfusion;Blood Vessels;Brain;brain behavior;Brain region;Caring;cerebral atrophy;cerebral hypoperfusion;Cerebrovascular Circulation;Chronic Kidney Failure;Clinical;Code;Cognition;Cognitive;cognitive function;cohort;Communities;comorbidity;comparison control;Control Groups;Data;Dementia;Diffusion;Digit structure;Disease;Dose;effective therapy;Ethnic Origin;executive function;Exercise;exercise adherence;exercise program;exercise training;functional decline;Functional Magnetic Resonance Imaging;Goals;Health;Hippocampus;Home;illness length;Impaired cognition;improved;information processing;Institutionalization;Learning;life span;Magnetic Resonance Imaging;Measures;Mediation;Medical;Memory;mild cognitive impairment;Moderate Exercise;morphometry;Nerve Degeneration;Neuronal Plasticity;Nonpharmacologic Therapy;older adult;Oxidative Stress;Participant;Patients;Perfusion;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pilot Projects;placebo group;poor health outcome;Population;Populations at Risk;premature;preservation;Prevalence;prevent;Prevention;primary outcome;Process;Randomized;Renal function;Rest;retention rate;Risk;Severities;Severity of illness;sex;side effect;Structure;systemic inflammatory response;Testing;Treatment Protocols;Walking;walking program;white matter;Work

PROJECT_TITLE: Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity (EXEC-study)


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: To advance the national “Ending the HIV Epidemic” (EHE) initiative and NIH Office of AIDS research priorities as well as to help close our regional gaps, the proposed Midwest Developmental Centers for AIDS Research (D-CFAR) seeks to advance transdisciplinary research, foster multi-sector collaboration and nurture emerging investigators addressing HIV/AIDS. These objectives will fill a geographical niche, leverage rich existing institutional resources, supply critical additional resources and thereby advance a transformative research agenda. At a moment when the EHE initiative has re-energized the response, an investment in research infrastructure for HIV can help create and deliver timely scientific insights to optimize momentum against the HIV pandemic in our region and beyond.

PI_NAMEs: GENG, ELVIN H. (contact);IWELUNMOR, JULIET

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS clinical trial group;Area;authority;base;Basic Science;Biological Assay;care delivery;Categories;CD4 Positive T Lymphocytes;Cessation of life;Clinical;Clinical Treatment;Collaborations;Communication;Communities;community engagement;Community Health;community partners;Complex;Consultations;Data;Dedications;Development;Diagnosis;dissemination science;economic impact;Effectiveness;Ensure;Environment;Epidemic;Equity;Evaluation;falls;Fostering;Funding;Future;Geography;Goals;Grant;Growth;Health Personnel;High Prevalence;Historically Black Colleges and Universities;HIV;HIV/AIDS;Hospitalization;implementation science;improved;Incidence;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Investments;Lead;Leadership;Long-Term Effects;Mentorship;Methods;Midwestern United States;Mission;Missouri;Modeling;multidisciplinary;Newly Diagnosed;next generation;NIH Office of AIDS Research;novel;pandemic disease;person centered;Persons;Pharmaceutical Preparations;Positioning Attribute;Process;process evaluation;programs;Public Health;racial disparity;racial minority;recruit;Research;Research Infrastructure;Research Personnel;Research Priority;Resources;response;Science;sexual minority;Sexually Transmitted Diseases;Social Impacts;Strategic vision;Structure;success;synergism;Testing;Time;Translational Research;United States National Institutes of Health;Universities;Viral Load result;Vision;Washington;Work

PROJECT_TITLE: Midwest Developmental Center for AIDS Research (D-CFAR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KSW-A (J2)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: GENG, ELVIN H. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Anti-Retroviral Agents;Attention;base;Cessation of life;co-infection;cohort;Collaborations;combat;Communication;Communities;community advisory board;community involvement;community organizations;Data;Dedications;Development;Diagnosis;Drug usage;Ensure;Environment;Epidemic;Epidemiology;Ethics;Evaluation;experience;Face;Funding;Future;Health;HIV;HIV diagnosis;HIV/AIDS;Housing;improved;Individual;Inflammation;Infrastructure;Injectable;injection drug use;Institution;Intervention;Investments;Lead;Leadership;Methods;Midwestern United States;Missouri;Modeling;Monitor;Nerve;Newly Diagnosed;novel;operation;Outcome;Persons;Pharmaceutical Preparations;Play;Positioning Attribute;Poverty;pre-exposure prophylaxis;Process;process improvement;Public Health;Reporting;Research;Research Activity;Research Personnel;Resources;response;Role;Science;Scientific Advances and Accomplishments;Secure;Sexual Transmission;Shapes;social determinants;Strategic Planning;Structure;tool;Training;translational impact;Translational Research;trend;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SSEWAMALA, FRED M (contact)

PROJECT_TERMS: Academia;Acquired Immunodeficiency Syndrome;Address;Applications Grants;Architecture;Attention;Award;California;career;career development;Clinical and Translational Science Awards;Communities;community academic partnership;community organizations;community partners;Complement;Consultations;design;Development;Diabetes Mellitus;Ecosystem;Educational workshop;Environment;Epidemic;Equity;Faculty;Feedback;Fostering;Funding;Funding Mechanisms;Goals;Growth;Historically Black Colleges and Universities;HIV;improved;Individual;Institution;Interdisciplinary Study;Internships;K-Series Research Career Programs;Leadership;leadership development;Long-Term Effects;medical schools;meetings;Mentors;Mentorship;Midwestern United States;Missouri;Monitor;Motivation;peer;peer learning;Play;Population Heterogeneity;programs;Public Health;Research;research faculty;Research Personnel;Resources;response;Role;San Francisco;satisfaction;Schools;Science;Scientific Advances and Accomplishments;Series;Social Work;Sociology;Source;Strategic Planning;Structure;Students;Study Section;success;symposium;System;Training;Training Programs;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PI_NAMEs: SHAN, LIANG  (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Applications Grants;Area;assay development;base;Basic Science;Biochemistry;Biological Assay;Cardiovascular Diseases;career;Cellular biology;Clinical;Clinical Sciences;Clinical Trials;co-infection;Collaborations;Communities;comorbidity;Consultations;cost effective;CRISPR/Cas technology;Data;design;Development;Discipline;Disease;drug discovery;Eligibility Determination;Ensure;Environment;Epidemic;experience;Fostering;Funding;Generations;Growth;Health;HIV;HIV/AIDS;Human;Human Resources;Image;Immunologics;Immunology;Immunophenotyping;improved;Inflammatory;Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Investigation;Investments;Laboratories;Leadership;Link;Measures;Mentorship;Metabolic Diseases;microbial;Midwestern United States;Mission;Motivation;multidisciplinary;multiple omics;National Center for Advancing Translational Sciences;Neurosciences;next generation;novel;Pathogenesis;Pathologic;Persons;pre-clinical;Pre-Clinical Model;Quality Control;Reagent;Research;Research Design;Research Personnel;research study;Resources;response;Science;Scientific Advances and Accomplishments;Secure;Services;single cell analysis;Structure;synergism;Technical Expertise;Technology;therapeutic development;Time;Training;Translating;translational potential;Translational Research;translational scientist;Translations;United States National Institutes of Health;Universities;vaccine development;vaccine discovery;virology;Washington;Work

PROJECT_TITLE: Advanced Technology-Core