ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: HONOLULU

ORG_NAME: QUEEN'S MEDICAL CENTER

ORG_STATE: HI

PHR: Project Narrative Our project will create a “Hawai‘i Health Equity Research and Outreach Network (HAWAI‘I HERON)” that will provide resources to support efforts to improve health equity for Asian American, Native Hawaiian and other Pacific Islander (AA-NHPI) populations. This work will be in collaboration with the Food and Drug Administration and other minority-serving institutions and will include a pilot study examining AA-NHPI patient preferences for diabetes medications. HAWAI‘I HERON has the potential to strengthen health equity focused research, outreach and communications, and training and mentoring of diverse students and junior researchers.

PI_NAMEs: SETO, TODD B (contact);TAIRA, DEBORAH ANN

PROGRAM_OFFICER_NAME: LEE, CHRISTINE


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Immunotherapy

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: INTEGRAL MOLECULAR

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal will contribute to public health and the cure of human disease by resulting in an FDA compliant tool for testing biotherapeutic cross-reactivity, enabling the development of therapeutic candidates with markedly improved likelihoods of succeeding in preclinical and clinical trials. The MPA will significantly decrease the number of unsafe therapeutics that enter preclinical and clinical trials and ultimately fail due to safety risks.

PI_NAMEs: DORANZ, BENJAMIN J (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Abbreviations;Adverse event;Antibodies;Automation;Avidity;Binding;Biological Assay;Biological Response Modifier Therapy;biopharmaceutical industry;CAR T cell therapy;Categories;Cells;Clinical;Clinical Trials;commercialization;cross reactivity;Data;Data Analyses;data integrity;data quality;Development;DNA;Documentation;drug development;Drug Screening;Ensure;Event;extracellular;Failure;Fc Receptor;FDA approved;Feedback;Funding;Goals;Head;head-to-head comparison;Human;human disease;Human Resources;Immunofluorescence Immunologic;improved;Industry;innovation;interest;Investigational Drugs;Laboratory Study;lead candidate;Lectin;Libraries;light scattering;Location;Measures;medication safety;Membrane;Membrane Proteins;Methods;Molecular;Molecular Conformation;Monoclonal Antibodies;Nature;new technology;novel strategies;novel therapeutics;Pharmaceutical Preparations;Plasmids;pre-clinical;preclinical trial;Process;Production;programs;Protein Array;Protein Secretion;Proteome;Public Health;Qualifying;quality assurance;Quality Control;Regulation;Reporting;Reproducibility;Research;Risk;Safety;safety study;Science;Services;Small Business Innovation Research Grant;Specificity;Spottings;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic development;timeline;Tissues;tool;tool development;Training;Validation

PROJECT_TITLE: Specificity Screening Drug Development Tool for Biotherapeutic Safety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Estrogen;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE____________________________________________________________________ Transgender women (TGW) are an understudied and underserved population, with an estimated global HIV prevalence of 19.9%; recently, long-acting intramuscular cabotegravir (CAB-LA) demonstrated efficacy for HIV prevention across populations, including TGW. However, knowledge gaps still exist, including a comprehensive understanding of the pharmacokinetic/pharmacodynamic (PK/PD) relationship of CAB-LA in HIV prevention, the potential influence of estrogen-based gender affirming hormone therapy (GAHT) on systemic and multi-compartment CAB pharmacology, and understanding pharmacologic risk windows in TGW and gender diverse persons assigned male at birth accessing estrogen-based GAHT. Additional work is required to address these gaps, which may provide future rationale for sex and gender-specific CAB-LA dosing with current or future CAB-LA formulations to optimize protection efficacy.

PI_NAMEs: MARZINKE, MARK A (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: absorption;Address;AIDS prevention;Antigens;assigned male at birth;Biological Assay;Biopsy;Birth;Blood;Body Composition;Body fat;Body mass index;Caring;Cervical;cervicovaginal;cis-female;cis-male;cisgender;Clinical Research;Clinical Trials;Colorectal;Communities;Complex;Data;Development;Disproportionately impacts women;Dose;Drug Interactions;Drug Kinetics;emtricitabine;Estradiol;Estrogens;Evaluation;falls;Fatty acid glycerol esters;Formulation;Frequencies;Fumarates;Future;Gender;gender affirming care;gender affirming hormone therapy;gender diverse;General Population;Generations;Goals;Health;High Prevalence;HIV;HIV Infections;HIV prevention trials network;HIV-1;Hormones;improved;inhibitor;Injections;insight;Integrase;inter-individual variation;Intramuscular;Intramuscular Injections;Knowledge;Length;Liquid substance;Measures;Medical;Modeling;Needles;Oral;Participant;Persons;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetic model;pharmacologic;Pharmacology;Plasma;Population;Populations at Risk;pre-exposure prophylaxis;Predisposition;Prevalence;prevent;Production;public health priorities;Quality of life;Rectum;Regimen;Reporting;Research;Risk;sex;sex assigned;simulation;Site;Tenofovir;Testing;Tissues;transgender;transgender women;transgender women who have sex with men;Underserved Population;Viral;Virus;Virus Replication;Woman;Work

PROJECT_TITLE: CHIPP-PrEP: Cabotegravir-Hormone Interrogation of Pharmacokinetics/Pharmacodynamics for HIV Prevention in Cisgender and Transgender Persons

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  The proposed study is directed at increasing the fundamental understanding of the causes, mechanisms, and prevention strategies of chronic kidney disease of unknown origin (CKDu) in Latin America. The study’s inclusion of examining sugarcane worker occupational exposure to particulate matter and its nephrotoxic constituents (silica, glyphosate, and heavy metals), renal biomarkers of effect, including early biological change, will advance our ability to identify factors that put individuals at risk for the development of CKDu and also detect illness at preclinical stages. Findings will lead to future interventions designed to reduce morbidity and mortality from CKDu in vulnerable populations around the world.

PI_NAMEs: ADGATE, JOHN L. (contact);NEWMAN, LEE S;SCHAEFFER, JOSHUA WILLIAM

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Address;Administrative Supplement;Adverse effects;Affect;agricultural community;Agricultural Workers;Agriculture;Air;air contaminant;Air Pollutants;Air Pollution;air sampling;amorphous silicate;Biological;Biological Markers;Blood;Blood Urea Nitrogen;Burn injury;Chronic;Chronic Kidney Failure;Clinical;cohort;Collaborations;Creatinine;cytokine;Data;Dehydration;Development;Diameter;Disease;Disease Progression;Environmental Pollutants;Epidemic;experience;exposure pathway;Exposure to;fine particles;Functional disorder;Future;General Population;glyphosate;Goals;Guatemala;Guatemalan;Harvest;Health;Heat Stress;Heavy Metals;Herbicides;High Prevalence;Hour;Humidity;Hydration status;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;Inhalation Exposure;Injury;Injury to Kidney;International;Intervention Trial;Investigation;Kidney;Kidney Diseases;kidney dysfunction;Latin America;LCN2 gene;Lead;Life;longitudinal design;Manuals;Measurable;Measurement;Measures;Mediating;Metals;Meteorological Factors;meter;Monitor;Morbidity - disease rate;mortality;nephrotoxicity;Occupational;Occupational Exposure;Osmolalities;Participant;Particulate;Particulate Matter;Pathogenesis;Pathway interactions;Pollution;poor health outcome;Population;post gamma-globulins;pre-clinical;prevent;Prevention strategy;prospective;Questionnaires;Recommendation;Recurrence;renal damage;Renal function;Research;Risk;Risk Factors;Role;Saccharum;Sampling;Seasons;Serum;shift work;Silicon Dioxide;Soil;Therapeutic;therapy design;Thick;Time;Urine;Vasopressins;Vulnerable Populations;Weight

PROJECT_TITLE: Particulate exposure and kidney health

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Midbrain dopamine (DA) neurons were classically thought to homogeneously encode reward prediction errors, but recent evidence has demonstrated that they also encode other behavioral variables, including value-neutral sensory prediction errors. Reconciling foundational concepts and these recent findings, as well as with what is known about the cellular properties and circuit connectivity of DA neurons, is currently one of the key challenges in the field. This project combines a validated odor-guided choice task with a new DA imaging approach developed by the candidate, as well as drug self-administration, chemogenetic, and gene editing methods, to test the hypothesis that spatiotemporal patterns of DA release encode a multi-factorial prediction-error teaching signal, and that the informational components of this signal are vulnerable to pathophysiological challenges, depend on the contribution of upstream cortical circuits, and are shaped by specific biophysical properties of DA neurons.

PI_NAMEs: COSTA, KAUE MACHADO (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Ablation;Affect;Agonist;Area;behavior measurement;Behavioral;biophysical properties;brain tissue;Chronic;Cocaine;cocaine self-administration;cocaine use;Cognitive;Collaborations;Corpus striatum structure;CRISPR/Cas technology;Data;designer receptors exclusively activated by designer drugs;Dimensions;Dopamine;dopaminergic neuron;Drug Modelings;Drug usage;Educational process of instructing;Event;experience;gene editing technology;gene-editing approach;Genetic;Goals;high dimensionality;Image;imaging approach;Implant;Influentials;Kv4 channel;Laboratories;Learning;lens;machine learning algorithm;Maps;meetings;Mentors;Methodology;Methods;Midbrain structure;Molecular;neural;neural circuit;Neurons;Neurophysiology - biologic function;new technology;Odors;Outcome;Pathologic;Pattern;Pharmaceutical Preparations;Phase;Postdoctoral Fellow;Procedures;programs;Property;Psychological reinforcement;Rattus;Resolution;Rewards;Rodent;Role;Saline;Self Administration;Sensory;Shapes;Signal Transduction;spatiotemporal;success;Sucrose;Testing;Training;Training Programs;transmission process;Virus

PROJECT_TITLE: Information encoding by spatiotemporal patterns of dopamine release


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The proposed research is directly relevant to public health and NIH’s mission, because our program will result in new functional and mechanistic understanding of immune suppressive mechanisms within tumor microenvironment. This new insight will directly translate into novel immunotherapies for the treatment of cancers.

PI_NAMEs: ZANG, XINGXING  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Ants;Award;Biology;Bladder;cancer immunotherapy;Cancer Patient;cancer therapy;CAR T cell therapy;CD276 gene;CD28 gene;CD80 gene;Cell Physiology;Cells;Clinical;Clinical Research;clinically significant;Colon;Combined Modality Therapy;Copy Number Polymorphism;CTLA4 gene;cytokine;Data;design;Esophagus;Family;Family member;Foundations;Funding;Gene Dosage;Goals;Grant;Homologous Gene;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immunosuppression;Immunotherapy;improved;innovation;insight;Islet Cell;Kidney;Legal patent;Liver;Lung Transplantation;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of thyroid;Malignant Neoplasms;Melanoma;member;Mission;Molecular;Monoclonal Antibodies;mouse model;neoplastic cell;new therapeutic target;novel;Outcome;Ovary;overexpression;Pancreas;Pathway interactions;PD-1/PD-L1;Phylogenetic Analysis;programmed cell death ligand 1;programmed cell death protein 1;programs;Prostate;Proteins;Public Health;Publications;receptor;Renal Carcinoma;Research;Skin;Structure;T-Lymphocyte;targeted treatment;Testing;Therapeutic;tool;Transgenic Mice;Translating;Treatment Efficacy;Trees;tumor;Tumor Immunity;tumor microenvironment;tumorigenesis;United States National Institutes of Health;VTCN1 gene

PROJECT_TITLE: The B7x pathways in the tumor microenvironment

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_DEPT: BIOLOGY

ORG_NAME: MORGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE – Overall During the current grant cycle, research conducted by RCMI@Morgan has significantly contributed to improving the health of minority and underrepresented communities in Baltimore and Maryland. Over the next 5 years, the Center will develop a more robust biomedical research ecosystem to foster innovative biomedical, socio- behavioral and clinical research aimed at improving minority health and reducing health disparities. The Center will empower MSU investigators to conduct innovative research on the underlying mechanisms that lead to health disparities, and to translate new knowledge into interventions to reduce or eliminate adverse health outcomes.

PI_NAMEs: TCHOUNWOU, PAUL B. (contact)

PROGRAM_OFFICER_NAME: JOSEPH, SUSAN KALAPURA

PROJECT_TERMS: academic program;Address;Advocacy;Affect;Area;Award;Bachelor's Degree;Baltimore;Basic Science;Behavioral Research;Behavioral Sciences;Biomedical Research;biomedical scientist;Cardiovascular Diseases;career;career development;Classification;Clinical Research;Clinical Sciences;Collaborations;collaborative environment;Communicable Diseases;Communication;Communities;community academic partnership;community based participatory research;community engagement;community organizations;Community Outreach;Community Participation;Data;design;Development;Diabetes Mellitus;Discipline;disease disparity;Drug Addiction;early-career faculty;Ecosystem;Educational process of instructing;Educational workshop;empowerment;Environment;Equity;Evaluation;expectation;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;Health equity research;improve minority health;improved;infancy;innovation;Institution;instrumentation;Interdisciplinary Study;Intervention;Investments;Joints;Knowledge;Learning;Logic;Mainstreaming;Malignant Neoplasms;Maryland;minority communities;minority health;minority health disparity;Modeling;Outcome;Pilot Projects;Play;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Publications;Recording of previous events;Reduce health disparities;Research;Research Activity;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Secure;service engagement;Social Behavior;Strategic Planning;Stress;Students;Substance abuse problem;success;supportive environment;symposium;synergism;tool;Training;Translating;translational potential;Translational Research;Underrepresented Minority;underrepresented minority student;underserved community;United States National Institutes of Health;Universities;Urban Community;Urban Health;urban health disparities;Vision;web site

PROJECT_TITLE: RCMI@Morgan: Center for Urban Health Disparities Research and Innovation

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 KNL (M1)]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Accounting;Address;Advisory Committees;Area;Baltimore;Basic Science;Behavioral Research;Biomedical Research;career development;catalyst;Cities;Clinical Research;Collaborations;Common Data Element;Communication;community engagement;Data;Development;disease disparity;Ensure;Evaluation;Extramural Activities;Faculty;formative assessment;Fostering;Funding;Goals;Grant;Health Disparities Research;health disparity;Health Promotion;implementation facilitation;improve minority health;improved;Infrastructure;infrastructure development;innovation;insight;Interdisciplinary Study;Leadership;Link;Logic;Maryland;Mentors;minority communities;minority scientist;Mission;Modeling;Modernization;Monitor;multidisciplinary;National Institute on Minority Health and Health Disparities;Occupational activity of managing finances;Outcome;Output;Performance;Productivity;professional atmosphere;programs;Recommendation;Reduce health disparities;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Structure;Technical Expertise;Technology Transfer;Training;Translational Research;Travel;underserved community;Universities;urban health disparities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WACHIRA, JAMES M (contact)

PROJECT_TERMS: 2019-nCoV;animal care;Animal Model;archive data;Archives;Area;Award;Baltimore;Basic Science;Behavioral Research;Behavioral Sciences;Biocompatible Materials;Bioinformatics;Biology;Biomedical Research;Biometry;Cancer Biology;Cardiovascular system;catalyst;Cell Physiology;Cells;Cellular biology;Clinical;Clinical and Translational Science Awards;Clinical Research;Collaborations;Communicable Diseases;Communities;community engagement;Computer software;Computers;Consult;Consultations;Core Facility;cost;cost effectiveness;Data;data access;Data Analyses;data archive;Data Collection;data management;Development;digital;Discipline;Education;Ensure;Environmental Health;epigenetic regulation;Equipment;Evaluation;Faculty;Feedback;Flow Cytometry;fluorophore;Funding;genetic analysis;Genomics;Goals;Grant;Health Disparities Research;Health Insurance Portability and Accountability Act;Human;human data;Immune;immunoregulation;improve minority health;improved;Informatics;innovation;Institution;Institutionalization;instrument;instrumentation;Laboratories;Laboratory Animal Production and Facilities;Laboratory Research;Maintenance;Malignant Neoplasms;Manuscripts;Maryland;Measurement;Measures;Memory;Microscopy;Molecular;Molecular and Cellular Biology;nanomaterials;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Neurosciences;nutrition;open source;Output;Patients;Performance;Pilot Projects;Practice Management;Process;Productivity;programs;Publications;Recovery;Reduce health disparities;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Schedule;Science;Scientific Advances and Accomplishments;Secure;Services;Stress;Structure;student training;success;synergism;System;Technical Expertise;Technology;The Jackson Laboratory;Training;United States National Institutes of Health;Universities;Urban Community;urban health disparities

PROJECT_TITLE: Research Capacity Core


PI_NAMEs: HOHMANN, CHRISTINE F (contact)

PROJECT_TERMS: Accountability;Applications Grants;Area;Award;Behavioral;behavioral health;Biomedical Research;career;career development;Clinical Investigator;Collaborations;Communities;community building;design;Development;Disease;Educational process of instructing;Educational workshop;Environment;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Growth;Health Disparities Research;health disparity;improve minority health;improved;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;Journals;learning community;learning network;Legal patent;Literature;Manuscripts;Mentors;Mind;Minority Groups;minority health;minority health disparity;multidisciplinary;NIH Program Announcements;Peer Review;Pilot Projects;Population;Postdoctoral Fellow;Procedures;Process;Productivity;programs;Protocols documentation;Publishing;Reduce health disparities;Research;research in practice;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resources;Science;Scientist;Series;social;Social Behavior;Specialized Center;STEM field;Structure;summer research;symposium;Technology Transfer;tool;Training;translational engagement;translational scientist;Underrepresented Populations;United States National Institutes of Health;urban health disparities;Writing

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SHEIKHATTARI, PAYAM  (contact)

PROJECT_TERMS: Academia;Address;Adopted;Affect;African American;Baltimore;Behavioral Research;career networking;Clinical;Clinical Research;Collaborations;Communication;Communications Media;Communities;community based participatory research;community based practice;community engagement;community partners;Computers;design;disease disparity;Dissemination and Implementation;Education;Educational Materials;Educational workshop;Equipment;equity, diversity, and inclusion;Event;evidence base;Faculty;Feedback;Fostering;Funding Opportunities;Future;Goals;Grant;Health Disparities Research;health disparity;Health education;health equity promotion;improve minority health;improved;Infrastructure;innovation;Institution;interest;International;Intervention;Journals;Knowledge;Latino;learning community;Location;meetings;member;Mentors;Mission;Modeling;Neighborhoods;outreach;patient oriented;Patients;Process;Productivity;program dissemination;programs;Provider;Public Health Schools;Publications;recruit;Reduce health disparities;Research;Research Personnel;Research Project Grants;Research Training;Resources;Services;Site Visit;Social Behavior;social media;Strategic Planning;Students;tool;Training;Translating;Translational Research;Universities;Urban Community;urban health disparities;Voice;Washington;web site;Work;Youth

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

PI_NAMEs: SHERCHAN, SAMENDRA P (contact)

PROJECT_TERMS: 2019-nCoV;Address;Aerosols;Affect;African American population;Area;artificial intelligence model;Black race;Cessation of life;Cities;cohort;Communities;community engagement;community transmission;coronavirus disease;Coupled;COVID-19;COVID-19 detection;COVID-19 diagnosis;COVID-19 pandemic;COVID-19 prevalence;COVID-19 vaccine;Cross-Sectional Studies;Data;Death Rate;deep neural network;Dependence;Detection;Diffusion;disease transmission;Disparity population;Effectiveness;effectiveness evaluation;emerging pathogen;enteric pathogen;environmental health disparity;Epidemiologic Monitoring;experimental study;exposure route;Feces;field survey;Fostering;Future;Goals;Health Disparities Research;health disparity;high risk;Hispanic;Hispanic Populations;Human;Individual;Inequity;Influenza;innovation;Laboratories;laboratory experiment;Latino;Latino Population;Light;Massachusetts;mathematical model;Mathematics;Measures;Methods;Minority Groups;Modeling;Molecular;Monitor;Monkeypox;Neighborhoods;Network-based;neural network architecture;Neural Network Simulation;New York;novel strategies;Oral;outbreak control;pandemic disease;Persons;Plants;Population;post-COVID-19;predictive modeling;Public Health;Publications;Pump;Race;racial disparity;recurrent neural network;Reporting;Research;respiratory;respiratory pathogen;Respiratory Signs and Symptoms;RNA;Route;Sampling;SARS-CoV-2 infection;Societies;socioeconomic disparity;Solid;System;tool;transmission process;United States;urban health disparities;Vaccination;Vaccines;Variant;viral outbreak;viral RNA;Virus;wastewater epidemiology;wastewater surveillance;World Health Organization

PROJECT_TITLE: Wastewater surveillance for addressing environmental health disparities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TULLOCH, INGRID K (contact)

PROJECT_TERMS: Affect;Baltimore;Behavioral;Biological;biopsychosocial;Black race;black women;Blood;Blood specimen;breast cancer metastasis;CD14 gene;Cell Physiology;cell type;Cells;chemokine;cytokine;Cytokine Gene;Data;Demographic Factors;Demographic Survey;design;differential expression;dimensional analysis;Dimensions;Discrimination;Disease;Disease susceptibility;DNA methylation profiling;Epigenetic Process;epigenetic regulation;Equation;ethnic identity;Ethnic Origin;experience;Flow Cytometry;Genetic Transcription;Genome;genome sciences;Genomics;Geography;Health;Health Disparities Research;Immune;Immune signaling;Immune system;Immunologics;immunoregulation;Individual;Infection;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;insight;Institution;interest;Interleukins;Intervention;Knowledge;Laboratories;Lipopolysaccharides;Macrophage;Maryland;Measures;Mediating;Methylation;methylation pattern;Mid-Atlantic Region;Modeling;Molecular;monocyte;Mononuclear;Nature;next generation;Organ;Outcome;Participant;Patient Self-Report;perceived discrimination;peripheral blood;Peripheral Blood Mononuclear Cell;Population;Population Group;Population Heterogeneity;Predisposition;Production;Psychometrics;psychosocial;Psychosocial Factor;Race;racial bias;racial discrimination;racial diversity;racial identity;Randomized;recruit;Regulation;Reporting;Research Personnel;response;Role;Signaling Protein;social;social exclusion;social inclusion;Statistical Data Interpretation;Techniques;Testing;Toxin;transcriptome sequencing;transcriptomics;trend;United States;Universities;urban health disparities;Urbanization;Variant;virtual;whole genome

PROJECT_TITLE: Perceived Discrimination, Geography, and Demographic Effects on Immune Cell Function and Regulation


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MEEKER, TIMOTHY J (contact)

PROJECT_TERMS: Address;Affect;Analgesics;Antineoplastic Agents;Applications Grants;Baltimore;Biological Markers;black patient;Black Populations;Black race;blind;Brain;Cancer Patient;Capsaicin;career;central pain;chemotherapy;chemotherapy induced neuropathy;Chemotherapy-induced peripheral neuropathy;cingulate cortex;Cities;Clinical Research;Clinical Trials;clinically relevant;combat;comparison intervention;Data;Dose;Double-Blind Method;duloxetine;effective intervention;effective therapy;endogenous opioids;Event;experience;experimental study;Functional Magnetic Resonance Imaging;Future;Goals;gray matter;Health Disparities Research;Home;Hospitals;Human;Hyperalgesia;Immune;Immunotherapy;Individual;Inflammation Mediators;Inflammatory;innovation;Intervention;Investigation;Magnetic Resonance Imaging;Malignant Neoplasms;Mechanics;Mediating;Mission;Motor Cortex;neural;neuroinflammation;Neuropathy;neurophysiology;noninvasive brain stimulation;Not Hispanic or Latino;novel;Odds Ratio;Opioid;Opioid Receptor Binding;Pain;pain processing;pain sensitivity;painful neuropathy;patient population;patient tolerability;Patients;Placebos;Platinum;Population;Positron-Emission Tomography;prevent;Principal Investigator;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Reporting;Research;research study;response;Risk;Self Administration;self supervised learning;Severities;Stimulus;Structure;Symptoms;taxane;Telemedicine;Therapeutic Effect;transcranial direct current stimulation;Treatment Efficacy;urban health disparities;Ventral Striatum;Visit

PROJECT_TITLE: Neural and Immune Correlates of Painful Chemotherapy-Induced Neuropathy, Feasibility and Preliminary Efficacy of a Motor Cortex Non-Invasive Brain Stimulation Intervention


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: TURING MEDICAL TECHNOLOGIES INC

ORG_STATE: MO

PHR: Project Narrative Magnetic resonance imaging (MRI) has unrivaled clinical and research utility, is non-invasive, and provides extremely high spatial resolution; however, MRIs have an Achilles heel: subject motion during scanning greatly diminishes the quality of the resulting images. Our software solution Framewise Integrated Real-Time MRI Monitoring (FIRMM) received FDA 510(k) clearance on August 26, 2020 and is currently being used in >75 research institutions; however, to ensure the commercial success of FIRMM, we need to expand the customer base to clinical institutions. The goal of this Commercialization Readiness Program (CRP) grant is to complete late-stage development and integrate with the Access-I technology to boost clinical marketing and sales support from Siemens Healthineers, required to translate FIRMM benefits from research to clinical care.

PI_NAMEs: KING, KEVIN  (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TITLE: Framewise Integrated Real-Time MRI Monitoring (FIRMM) software commercialization readiness for clinical care


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PI_NAMEs: GUILLOT-WRIGHT, SHANNON PAIGE (contact)

PROGRAM_OFFICER_NAME: CHIOU, SHARON

PROJECT_TITLE: K01 Mentored Research Scientist Development Award

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Hematology;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In preterm infant brain injury, disruption of the blood-brain barrier (BBB) allows the blood clotting protein fibrinogen to leak into the nervous system. We hypothesize that fibrinogen stops stem cells from transforming into mature neurons and myelin-producing oligodendrocytes in the developing brain. The goal of this project is to determine the cellular and molecular mechanisms that underlie fibrinogen's inhibitory effects in the injured newborn brain to identify new therapeutic targets and strategies to promote normal brain development.

PI_NAMEs: PETERSEN, MARK A (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: activin A;Alzheimer's Disease;Area;Binding;Biological Assay;Blood - brain barrier anatomy;Blood coagulation;Blood Proteins;Blood Vessels;blood-brain barrier disruption;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;Brain;brain dysfunction;Cell Maturation;cell transformation;Cells;Cellular Assay;Central Nervous System;central nervous system injury;Chronic;Cicatrix;Co-Immunoprecipitations;Cytoplasmic Granules;Data;defined contribution;Deposition;design;Development;Developmental Disabilities;Environment;Event;experience;Failure;Fibrinogen;Fibrinogen Receptors;Funding;Gene Expression Profile;Goals;Growth;Hemorrhage;Hypoxia;Impairment;In Vitro;in vivo;infant brain injury;inhibitor;injured;Integrins;intraventricular hemorrhage;Intraventricular Injections;Knockout Mice;Knowledge;Label;Ligands;Link;Mediating;Modeling;Molecular;Multiple Sclerosis;Mutant Strains Mice;Myelin;myelination;neonatal brain;Neonatal Brain Injury;neonatal mice;Nerve Degeneration;nerve stem cell;Nervous System;Nervous System Disorder;neurodevelopment;neurogenesis;neuroinflammation;Neurons;neurovascular;new therapeutic target;newborn brain injury;novel;novel therapeutic intervention;oligodendrocyte progenitor;Oligodendroglia;Pathologic;Pathology;Pathway interactions;pharmacologic;Physicians;Premature Birth;Premature Infant;Preterm brain injury;prevent;Production;progenitor;Proteins;receptor;repaired;Reporter;Research;response;Risk;Role;Scientist;Signal Transduction;Signaling Protein;Site;skills;Slice;stem cell niche;stem cells;Testing;Therapeutic;therapeutic target;thrombotic;Time;transcriptome;transcriptome sequencing;Traumatic injury;two photon microscopy;Work

PROJECT_TITLE: Fibrinogen-mediated mechanisms of preterm infant brain injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Cells rely on numerous feedback mechanisms to detect and respond to membrane protein misfolding, yet the mechanistic details of this feedback remain unclear. In the following, we outline new findings linking cotranslational misfolding to ribosomal frameshifting and outline a series of investigations to gain insights into the structural basis of this crosstalk as well as its role in the molecular basis of disease. The results will provide insights into a fundamentally new manner of translational regulation that appears to be operative within a wide array of disease-linked human membrane proteins.

PI_NAMEs: SCHLEBACH, JONATHAN PATRICK (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Alpha Virus;Base Sequence;Binding;Biochemical;Biochemistry;Cells;Chloride Channels;Code;Complex;conformational conversion;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;Delta F508 mutation;Development;Disease;Elements;Equilibrium;experimental study;Face;FDA approved;Feedback;Genetic;Human;Hydrophobicity;improved;insight;Integral Membrane Protein;Investigation;Knowledge;Link;Lipid Binding;Maintenance;Maps;Measures;mechanical force;Mechanics;Mediating;Membrane;Membrane Proteins;Molecular;Molecular Chaperones;Molecular Conformation;molecular modeling;Mutation;mutation screening;novel;Pathogenicity;Pharmaceutical Preparations;Play;polypeptide;Polyproteins;Potential Energy;premature;prevent;Property;Protein Analysis;Protein Biosynthesis;protein degradation;protein folding;protein misfolding;Proteins;Proteome;proteostasis;proteotoxicity;Quality Control;Reaction;response;Ribosomal Frameshifting;Ribosomes;RNA;Role;Series;Sindbis Virus;Site;small molecule;Stimulus;Stress;Structural Models;Structure;Testing;Therapeutic;transcriptome;Translational Regulation;Translations;Transmembrane Domain;virology;Work

PROJECT_TITLE: Stimulation of Ribosomal Frameshifting by Cotranslational Membrane Protein Folding and Misfolding

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Orphan Drug;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cytochrome P450 (CYP) 11B1 and 11B2 synthesize cortisol and aldosterone respectively, with excesses resulting in Cushing’s disease and primary aldosteronism. Drug treatments for each disease are limited due to poor drug selectivity resulting from the high similarity between these enzymes. This proposal aims to define differences between CYP11B1 and CYP11B2 active sites and interactions with common redox partner adrenodoxin, advances that may facilitate more effective drug design.

PI_NAMEs: LOOMIS, CARA LORENE (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Active Sites;Adrenodoxin;Affinity;Aldosterone;Binding;Biochemical;Biological Assay;Cardiovascular system;Catalysis;Clinical;Complex;Cortodoxone;CYP11A1 gene;CYP11B1 gene;Cytochrome P450;Data;design;Development;Disease;Distant;Drug Design;Enzyme Interaction;Enzymes;FDA approved;Future;Goals;Human;Hydrocortisone;Hyperaldosteronism;Hypertension;Immunosuppression;improved;inhibitor;insight;Investigation;Kinetics;Ligand Binding;Ligands;Literature;Membrane;Metabolic;Mutagenesis;novel strategies;Outcome;Oxidation-Reduction;Pharmaceutical Preparations;Pharmacotherapy;Pituitary-dependent Cushing's disease;prevent;Proteins;Research;Roentgen Rays;Role;Sequence Homology;Structure;Structure-Activity Relationship;Surface;System;therapy design;Weight Gain

PROJECT_TITLE: Defining Structural and Functional Differences Between Cytochrome P450 11B1 and 11B2 Interactions with Redox Partner Adrenodoxin for Developing Cushing's Disease and Primary Aldosteronism Treatments


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Palliative Care;Patient Safety;Prevention;Radiation Oncology

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Radiotherapy is routinely employed in the treatment of cancer and can cause a myriad of toxicities that may significantly affect quality of life during and after treatment. Through rigorous clinical research, I aim to optimize the therapeutic index of cancer treatment by maximizing the effectiveness of treatment, minimizing the toxic effects of radiotherapy, understanding treatment toxicity and its effect on short- and long-term quality of life, and developing cancer control and symptom-directed risk mitigation strategies. The proposed research and career development activities outlined in this application will propel me on the path of becoming an independent clinical investigator and ensure that I am successful in advancing cancer clinical research at my institution and within multiple NCI-supported research groups.

PI_NAMEs: MESA, RUBEN A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Administrative Supplement;Advanced Malignant Neoplasm;Affect;Aftercare;anti-cancer research;Baptist Church;base;Biometry;Cancer Control;cancer therapy;career;career development;Center Core Grants;Clinical;Clinical Investigator;Clinical Investigator Award;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Community Clinical Oncology Program;Comprehensive Cancer Center;Conduct Clinical Trials;Dedications;design;Educational Activities;Educational workshop;Ensure;experience;Funding;Goals;Head and Neck Cancer;Head and neck structure;Health;Heart Atrium;Hematologic Neoplasms;improved;Industry;Institution;interest;investigator-initiated trial;Leadership;Malignant Neoplasms;medical schools;member;Mentors;Metastatic/Recurrent;Mission;National Cancer Institute;Oncology;Outcome;Outcomes Research;participant enrollment;Patient Outcomes Assessments;Patients;Pilot Projects;professor;programs;Prospective Studies;Quality of life;Radiation Oncologist;Radiation Oncology;Radiation therapy;Reporting;Research;research and development;Research Personnel;Research Support;risk mitigation;Role;Schools;survivorship;symptom management;Symptoms;Therapeutic Index;Time;Toxic effect;Training;Treatment Effectiveness;Treatment-related toxicity;Universities;Work;working group

PROJECT_TITLE: National Cancer Institute (NCI) Early Career Cancer Clinical Investigator Award (ECIA) P30 Administrative Supplement

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Precision Medicine;Stimulant Use and Misuse;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Converging lines of research support the utilization of deep transcranial magnetic stimulation (dTMS) as a novel, non-pharmacologic approach to improving treatment outcomes for those with methamphetamine use disorder (MUD) by modulating neural circuits related to relapse. The results of this study will be used to determine whether the proposed dTMS protocol has an effect on neural target engagement and subsequent use behaviors (% days abstinent). These data will set the foundation for increasing the clinical indications of dTMS to be used as an innovative, new treatment option for individuals with MUD.

PI_NAMEs: MADORE, MICHELLE ROSEANN;PADULA, CLAUDIA B. (contact)

PROGRAM_OFFICER_NAME: FOSTER, KATRINA L

PROJECT_TERMS: Acceleration;addiction;Adult;Affect;Affective;Aftercare;arm;Behavior;behavior change;Behavioral;Bilateral;Biological Assay;Biological Markers;Brain;Clinical;Clinical Research;Clinical Trials;Cocaine use disorder;cohesion;Controlled Clinical Trials;Data;design;Development;Devices;diagnostic criteria;Disease;Dose;Double-Blind Method;Drug usage;DSM-V;Enrollment;evidence base;FDA approved;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Impairment;improved;Individual;innovation;Insula of Reil;Intervention;Measures;Mediating;methamphetamine use;Methamphetamine use disorder;Methods;Multi-Institutional Clinical Trial;neural;neural circuit;neural network;neuroimaging;Neurons;neuroregulation;Nonpharmacologic Therapy;novel;novel therapeutic intervention;Nucleus Accumbens;open label;outcome prediction;Participant;Patient Self-Report;Patients;Phase;Physiologic pulse;pre-clinical research;preclinical study;Prediction of Response to Therapy;Prefrontal Cortex;Protocols documentation;Randomized;Relapse;relapse prediction;relapse risk;repetitive transcranial magnetic stimulation;Research;Research Support;Residential Treatment;Rewards;Role;Sample Size;Scanning;smoking cessation;stimulant use disorder;Substance Use Disorder;Techniques;Testing;Time;Transcranial magnetic stimulation;treatment as usual;Treatment outcome;Treatment Protocols;treatment response;treatment site;white matter

PROJECT_TITLE: Deep TMS Neuromodulation of Neural Circuits Associated with Stimulant Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 TXT-M (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chronic liver injury leads to fibrotic liver injury and cirrhosis, a condition without current therapy. Yap/Taz/Cyr61 activity during liver regeneration triggers fibrotic programs through common and divergent mechanisms, some of which could be modified to improve liver regeneration and overall health.

PI_NAMEs: YIMLAMAI, DEAN  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acute;Address;Affect;arm;Behavior;Biochemical;Biochemical Pathway;Biochemistry;candidate validation;Cell Communication;Cell Proliferation;Cells;Characteristics;Chemicals;chemokine;chromatin immunoprecipitation;Chronic;chronic liver injury;Cirrhosis;Compensation;Complex;Data;Decision Making;Development;differential expression;Disparity;Endothelial Cells;Enterobacteria phage P1 Cre recombinase;Environment;Epithelial Cells;Epithelium;extracellular;Fibroblasts;Fibrosis;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;genetic approach;Genetic Transcription;genomic profiling;Genomics;Goals;Health;Hepatic Stellate Cell;Hepatocyte;high dimensionality;imaging approach;Immune;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;Liver;Liver Cirrhosis;Liver Fibrosis;liver inflammation;liver injury;Liver parenchyma;Liver Regeneration;Macrophage;Mediating;Medical;Modeling;monocyte;Myofibroblast;Natural regeneration;next generation sequencing;nonalcoholic steatohepatitis;Nonpenetrating Wounds;novel;Organ;Outcome;overexpression;paralogous gene;Pathway interactions;Phenotype;Play;programs;Publishing;receptor;recruit;Regenerative response;Reporting;Research Personnel;response;response to injury;Role;Signal Pathway;Signal Transduction;Structure;Therapeutic;tissue regeneration;Work

PROJECT_TITLE: Deciphering Epithelial Signals in the Liver to Drive Inflammation and Fibrosis

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Cancer is a deadly disease for which there is no panacea but requires a multi-pronged approach to improve the outcomes of our patients. To that end, the Herbert Irving Comprehensive Cancer Center at Columbia University Irving Medical Center/New York Presbyterian Hospital is dedicated to the vision and mission of reducing the cancer burden in our catchment area. The HICCC spans basic, translational, clinical and population research that is supported by shared resources, community outreach and engagement, training and education, and strategic investments, all converging on cancer screening, surveillance, early detection, prognosis, therapy, survivorship and palliation.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROJECT_TERMS: Administrative Supplement;anti-cancer research;authority;Basic Science;Cancer Burden;Cancer Care Facilities;Cancer Center;Cancer Center Support Grant;cancer education;cancer genomics;cancer research center director;career;Catchment Area;Center Core Grants;Clinical;Clinical Investigator Award;Clinical Research;Clinical Sciences;Clinical Trials;community engagement;Community Outreach;Dedications;Disease;Dryness;Early Diagnosis;Education and Outreach;epigenomics;Faculty Recruitment;Family;Funding;Gifts;Herbert Irving Comprehensive Cancer Center;Hospitals;improved outcome;innovation;Investments;laboratory facility;Laboratory Research;Malignant Neoplasms;Medical center;member;Mission;National Cancer Institute;New York;Oncology;palliation;panacea;Patient Care;Patients;Population Research;Population Sciences;precision oncology;Presbyterian Church;Prognosis;programs;Publications;recruit;Research;Resource Sharing;Resources;response;Role;Schools;Science;Screening for cancer;Services;survivorship;Systems Biology;Training and Education;Translational Research;Trust;Tumor Biology;tumor microenvironment;Universities;Vision

PROJECT_TITLE: Cancer Center Support Grant - Early Career Cancer Clinical Investigator Award (ECIA)


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: WELLESLEY

ORG_NAME: BABSON COLLEGE

ORG_STATE: MA

PHR: Project Narrative The ability to coordinate or match drug addiction scientists with business, regulatory, and financing experts (referred to as ‘entrepreneurial leaders’) is key to establishing societal and commercial solutions in this subject area. Having a database to search for specific characteristics or knowledge, and a platform to identify and introduce potential partners in is expected to lead to longer associations and startup success. We will also generate and track possible measures regarding networking success between scientists and entrepreneurial leaders and regarding SUD startup successes and publish findings forthwith.

PI_NAMEs: GLOVER, WILJEANA  (contact);ONYEMAH, VINCENT ;RANDOLPH, ANGELA

PROGRAM_OFFICER_NAME: LUKACS, JESSICA MICHELLE

PROJECT_TERMS: Adoption;Applications Grants;Area;Artificial Intelligence platform;Biological Sciences;Businesses;Characteristics;cohort;commercialization;Communication;Data;Databases;Drug Addiction;Educational Curriculum;Educational Status;Eko;Employee;Event;experience;Feedback;follow-up;Fostering;Government Financing;Grant;Growth;Health financing;Immersion;interest;Knowledge;Knowledge acquisition;Legal;Link;Magic;Measurement;Measures;Medical;meetings;Mentors;National Institute of Drug Abuse;new technology;Outcome;Participant;Patient Recruitments;Persons;Process;product development;Program Effectiveness;programs;Public Health;Publishing;Research Personnel;Scientist;searchable database;skill acquisition;skills;Small Business Innovation Research Grant;social health determinants;success;Surveys;U-Series Cooperative Agreements;virtual

PROJECT_TITLE: Babson Life Sciences Entrepreneurial Product Development Immersion for New Technologies and Solutions (Babson L-SPRINT) Program


ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: PROJECT NARRATIVE The practical translation of new knowledge, mechanisms, and techniques generated by advances in basic biomedical science research into new approaches for preventing, diagnosing, and treating diseases is essential to addressing health disparities of our diverse community. At the NYCenter for Minority Health Equity and Social Justice, we intend to continuously seek community input at all stages of research, adding an additional dimension to the traditional bench -> bedside paradigm, and in doing so, create a national model to solve health disparities.

PI_NAMEs: GREEN, CARMEN RENEE;LIMA, MARIA F (contact)

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Address;Administrator;Adolescent;Affect;African American population;Artificial Intelligence;Award;Basic Science;Behavioral;behavioral and social science;Behavioral Sciences;bench to bedside;Biological Sciences;Biomedical Research;Biometry;Charge;Cities;Clinical;Clinical Research;Clinical Trials;Collaborations;college;Communication;Communication Methods;Communities;community engagement;community involvement;community partners;community partnership;Computational Science;COVID-19;Critiques;dashboard;Data Science;design;Development;Diagnosis;Dimensions;Discipline;Disease;Disparity;Doctor of Philosophy;Elements;End stage renal failure;Engineering;Epidemiology;Equity;Evaluation;experience;Extramural Activities;Faculty;Faculty Recruitment;Funding;Genomics;Goals;Grant;Health;Health Disparities Research;health disparity;health disparity populations;health equity;Health Services;Health Services Research;Hispanic Populations;Human Resources;improved;Individual;innovation;Institution;Knowledge;Latino;Lead;Leadership;Location;Measures;Mental Health;Mentors;Minority;Minority Groups;minority health;minority health disparity;Minority-Serving Institution;Mission;Modeling;Molecular Biology;multi-ethnic;multi-racial;multidisciplinary;Multilingualism;New York;novel;novel strategies;Parkinson Disease;Persons;Pilot Projects;population health;Preparation;prevent;Process;programs;Published Comment;Qualifying;Recording of previous events;Records;recruit;Research;Research Design;research facility;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Schools;Science;Scientific Advances and Accomplishments;Seasons;Social Justice;Social Mobility;social stigma;Social Work;Solid;synergism;Techniques;Technology;Time;timeline;Training;Training Activity;Translations;Underrepresented Minority;Universities

PROJECT_TITLE: NYCenter for Minority Health, Equity and Social Justice


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Per Funding Opportunity Announcement (FOA) Number RFA-MD-24-001 Project Narrative: Do not complete. Note: ASSIST screens will show an asterisk for this attachment indicating it is required. However, eRA systems only enforce this requirement in the Overall component and applications will not receive an error if omitted in other components.

PI_NAMEs: LIMA, MARIA F (contact)

PROJECT_TERMS: Address;Aging;Articulation;Budgets;career;career development;Cities;college;Common Data Element;Communication;Communities;community engagement;Community Health;Dedications;Development;Discipline;Doctor of Philosophy;Effectiveness;empowerment;Ensure;Equity;Ethnic Origin;Evaluation;Faculty;follow-up;Fostering;Funding;Funding Opportunities;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;improve minority health;improved;innovation;Institution;Leadership;Learning;Linguistics;Location;Logistics;medical schools;member;Mentors;minority health;minority health disparity;Minority Health Research;minority student;Mission;Monitor;Mosses;multi-racial;National Institute on Minority Health and Health Disparities;New York;Performance;Policies;Principal Investigator;Program Evaluation;programs;Progress Reports;Recommendation;recruit;Reduce health disparities;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scientist;Seasons;Shapes;Social Justice;Societies;success;Suggestion;System;timeline;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: UNDIEH, ASHIWEL S (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;Affect;algorithmic bias;Algorithms;analytical tool;Artificial Intelligence;Awareness;Behavioral;Behavioral Research;Biomedical Research;Biopsy Specimen;ChatGPT;Cities;Clinical;Clinical Research;cognitive skill;college;Communication;Communication Tools;Communities;community engaged research;community engagement;Community Participation;Consultations;County;CRISPR/Cas technology;Data;Data Analytics;Data Collection;Data Reporting;Data Security;data tools;data warehouse;design;Devices;Diagnostic;Discipline;Disparity;economic disparity;Educational workshop;empowerment;Epigenetic Process;Equipment;Equity;experience;Expert Systems;Faculty;falls;Familiarity;frontier;Funding Opportunities;Genomics;Goals;Health;health care availability;Health Disparities Research;health disparity;Health Service Area;Household;ideation;imaging study;Improve Access;improved;Income;Inequity;innovation;instrumentation;Laboratories;Language;learning algorithm;member;Mentors;Microscopy;minority communities;minority health;Network Infrastructure;New York;New York City;operation;Participant;Personal Satisfaction;Pilot Projects;Principal Investigator;Productivity;Professional counselor;recruit;Recurrence;Reduce health disparities;Reproducibility;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resources;Risk;Science;Services;Social Justice;Structure;success;System;Talents;Techniques;Technology;Thinness;tool;Training;underserved community;United States National Institutes of Health;whole animal imaging;Work

PROJECT_TITLE: Research Capacity Core


PI_NAMEs: VILLALTA, FERNANDO  (contact)

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Applications Grants;Area;Award;Basic Science;Behavioral Research;Bioinformatics;biomedical profession;Biomedical Research;Biometry;career;career development;Clinical Research;Communities;community engagement;Community Health;community partners;Consultations;Coupled;Creativeness;Data;data submission;Development;Development Plans;Disease;Disparity population;Ensure;Equity;Extramural Activities;Faculty;Fostering;Foundations;Funding;Funding Opportunities;Goals;Grant;Health;Health Disparities Research;health disparity;innovation;Institution;Leadership;Link;Location;Low income;Mentors;Minority;Minority Groups;minority health;minority healthcare;Mission;Modeling;new technology;novel;Outcome;Outcomes Research;Participant;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Productivity;professor;programs;Publications;Recording of previous events;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Schools;Scientist;Social Justice;Social Medicine;student participation;success;System;Teacher Professional Development;timeline;Training;training opportunity;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;underserved community;United States National Institutes of Health

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PASHA-RAZZAK, OMRANA  (contact)

PROJECT_TERMS: Address;Adolescent;Affect;African American population;Applications Grants;Area;Catchment Area;Chinese American;Collaborations;Communication;Communities;community academic partnership;community advisory board;community based participatory research;community engaged research;community engagement;community engagement process;community involvement;community organizations;Community Participation;community partners;community partnership;Data;Databases;design;Development;Discipline;Disease;Disparity;Effectiveness;End stage renal failure;Ensure;Environment;Equity;ethnic minority;ethnic minority population;Ethnic Origin;Face;Family;Fostering;Funding Opportunities;Generations;Geography;Goals;Grant;Health;health care availability;health care service;Health Disparities Research;health disparity;health disparity populations;Health Personnel;health professional shortage areas;Hispanic Populations;improve minority health;improved;Individual;Inequality;interest;Intervention;Investigation;Knowledge;Linguistics;Low income;marginalization;Medical;member;Mentors;Methods;Minority;minority communities;Minority Groups;minority health;Morbidity - disease rate;mortality;multi-racial;New York City;Outcome;Outcomes Research;outreach;Parkinson Disease;Persons;Pilot Projects;Play;Population;population health;Process;Public Health;Quality of life;racial minority;racial minority population;Reduce health disparities;Relationship-Building;Research;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;Role;Science;Scientific Advances and Accomplishments;Scientist;Series;skills;Social Justice;Societies;System;Technology;tool;Training;Trust;underserved community;Work

PROJECT_TITLE: Community Engagement Core


PI_NAMEs: MARTIN, JOHN H (contact)

PROJECT_TERMS: Address;Affect;Appointment;Attention;Basic Science;Behavioral;Behavioral Research;Behavioral Sciences;Bioinformatics;Caliber;career;Cities;City Planning;Clinical;Collaborations;college;community engagement;cultural health;Development;Development Plans;Discipline;Educational process of instructing;Engineering;Ensure;Environment;Equity;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Goals;Health;Health Disparities Research;health disparity;health equity;Health Services;Health Services Research;Individual;Institution;interest;Joints;Leadership;Letters;Logistics;medical schools;member;Mentors;Mentorship;Minority Groups;minority health;minority health disparity;Mission;multidisciplinary;New York;New York City;Pilot Projects;Postdoctoral Fellow;Productivity;programs;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Support;research vision;Resources;Role;Scholarship;Schools;Science;Scientist;senior faculty;Senior Scientist;Social Justice;Strategic Planning;success;System;Teacher Professional Development;Time;Underrepresented Minority;Universities;Vision;Wages;Work;Writing

PROJECT_TITLE: Recruitment Core


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nanotechnology;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WILLIAMS, RYAN MARTIN (contact)

PROJECT_TERMS: absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;African American population;American;Amiloride;analog;Animals;Award;biocompatible polymer;Biological Assay;Biological Products;Biomedical Engineering;caucasian American;Cells;Cellular biology;Chronic;Chronic Kidney Failure;Clinic;Clinical;clinical translation;Clinical Trials;Collaborations;cost estimate;Data;Diabetes Mellitus;Diagnosis;Dialysis procedure;Disease;Disparity;Diuretics;Drug Kinetics;efficacy testing;Encapsulated;End stage renal failure;Enzymes;Epigenetic Process;Epithelium;Equity;Etiology;Excretory function;Exhibits;Exposure to;FDA approved;Financial Hardship;Focal Adhesions;Formulation;Funding;Funding Opportunities;Future;Genetic;glomerular filtration;Goals;Grant;Health;health disparity;Hypertension;Impairment;improved;In Vitro;in vivo;Individual;inhibitor;Injury;innovation;Joints;Kidney;Kidney Diseases;Kidney Transplantation;Lead;medical schools;member;Memorial Sloan-Kettering Cancer Center;Mentors;Messenger RNA;Metabolism;minority health;Modeling;Morbidity - disease rate;mortality;mouse model;nanomedicine;nanoparticle;Nephrology;novel;Organ;particle;Pathogenesis;Patients;Peptides;Pharmaceutical Preparations;Pharmacology;Pharmacology Study;Plasminogen;Plasminogen Activator;podocyte;Population;porcine model;pre-clinical;Production;protective effect;Publications;Publishing;Reduce health disparities;Renal glomerular disease;Risk Factors;Rodent;Rodent Model;Role;Small Interfering RNA;small molecule;Social Justice;socioeconomics;System;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic target;Toxicology;Translating;Treatment Efficacy;Tubular formation;United States National Institutes of Health;Work

PROJECT_TITLE: Nanoparticle-targeted therapeutic development for glomerular diseases


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: LU, WENHUA  (contact)

PROJECT_TERMS: Address;Adolescent;adolescent mental health;Age;American;Anxiety;Asian Americans;Attitude;Belief;Black Populations;Budgets;Caring;Cause of Death;Child Mental Health;child neglect;Chinese;Chinese American;Clinical;Clinical Research;Communities;comparison control;Complex;Consolidated Framework for Implementation Research;Control Groups;culturally appropriate intervention;Data;Diagnosis;empowerment;Ensure;Equity;Ethnic Population;evidence base;Evidence based practice;expectation;experience;Failure;Family;follow up assessment;Funding;Funding Opportunities;Generations;group intervention;health service use;Health Services Research;help-seeking behavior;high risk;High School Student;Immigrant;Immigrant family;implementation framework;implementation intervention;improved;Individual;innovation;intergenerational;Internet;Interpersonal Relations;Intervention;intervention mapping;Knowledge;Latino Population;lens;Linguistics;Low income;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Middle School Student;Mind;Minority;Minority Groups;minority health;minority stress;minority stressor;Modeling;Mood Disorders;New York City;online intervention;Pacific Islander;pandemic disease;parental influence;Parents;pilot test;Population;prevent;Professional counselor;Protocols documentation;psychological distress;racial discrimination;racial population;Randomized;Randomized, Controlled Trials;recruit;referral services;Research;retention rate;Risk;Schools;Science;Self Efficacy;Social Justice;social stigma;Stereotyping;Students;Subgroup;success;Suicide;System;systematic review;Testing;therapy development;United States National Institutes of Health;Work

PROJECT_TITLE: Empowering Chinese American Adolescents and Parents for Mental Health Help-Seeking


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Parkinson's Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: GHILARDI, M. FELICE MARINA (contact)

PROJECT_TERMS: Address;Adherence;Aftercare;Aging;Area;Awareness;Caregivers;Caring;Central American;clinical care;Clinical Research;Clinical Trials;cognitive performance;cohort;Communities;Community Health Education;community organizations;Community Outreach;Community Participation;Complex;Data;Disease;Disease Management;Education;effectiveness testing;Enrollment;Equity;Ethnic Population;Exercise;experience;Family;Feasibility Studies;Feedback;Fostering;Foundations;Funding Opportunities;Future;Goals;Growth;Health;health care availability;health care disparity;health care service;Health Educators;Health Promotion;Healthcare;Hispanic;hispanic community;Hispanic Populations;Hospitals;improved;Incentives;Incidence;Income;Inequality;Infrastructure;Inpatients;instrument;Intervention;Knowledge;Language;Latino;Marital Status;Measures;Minority;Minority Enrollment;minority health;Modeling;Monitor;Motor;motor symptom;multidisciplinary;Neurodegenerative Disorders;New York City;Newsletter;non-motor symptom;Not Hispanic or Latino;novel;outpatient programs;Outpatients;outreach;Parkinson Disease;Participant;participant enrollment;Patient Compliance;Patient Monitoring;Patient Participation;Patients;Perception;Performance;Personal Satisfaction;Persons;Play;Population;programs;Prospective Studies;Quality of life;racial population;recruit;Reduce health disparities;Rehabilitation therapy;Research;Research Design;research study;Resources;safety and feasibility;Social Justice;social media;social stigma;socioeconomic disadvantage;socioeconomics;South American;Spanish;success;Symptoms;System;Testing;Time;tool;Training;Translating;underserved community;web site;Work

PROJECT_TITLE: Creating tools to enhance PD care and research participation of Hispanic-Latino community


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: SURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Summary/Abstract Not required for submission to Administrative Supplement to Cancer Center Support Grants (P30 CCSGs).

PI_NAMEs: LIBUTTI, STEVEN K. (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Administrative Supplement;anti-cancer research;biomarker driven;Cancer Center Support Grant;career;Clinical Investigator;Clinical Investigator Award;Clinical Trials;Early Therapeutic-Clinical Trials Network;Goals;Institution;Investigation;Malignant Breast Neoplasm;Malignant Neoplasms;National Cancer Institute;novel;Patients;Scientist;Therapeutic

PROJECT_TITLE: National Cancer Institute Early Career Cancer Clinical Investigator Award


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative A new mouse model recently commercialized by GenOway will be used to perform key experiments testing the potential therapeutic effects of anti-human CD3 Fab fragments derived from the monoclonal antibody OKT3 specific for the ectodomain of human CD3. The goal is to determine the potential therapeutic effects of Mono- OKT3-Fab against cancer when targeting functional T cells in tumor hosts that are immunocompetent and tolerant to the tumor. Positive results in the GenOway model, in conjunction with our current data in immunocompromised mice, would make a solid case to pursue further steps towards clinical translation of Mono-OKT3-Fab as a novel T cell targeted immunotherapy against cancer.

PI_NAMEs: GIL PAGES, DIANA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: anti-tumor immune response;Antibodies;antitumor effect;Autologous;Award;B-Cell Neoplasm;Binding;CD3 Antigens;Chemosensitization;chimeric gene;clinical translation;commercialization;crosslink;Cytoplasmic Tail;Data;design;Development;Epitopes;experimental study;Fab Immunoglobulins;Genes;Goals;Human;Immune Tolerance;Immunocompetent;Immunocompromised Host;Immunoglobulin G;Immunotherapy;Knock-in;Knock-in Mouse;Malignant Neoplasms;Mature T-Lymphocyte;Membrane;Modeling;Monoclonal Antibodies;mouse model;Muromonab-CD3;Mus;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;patient derived xenograft model;Reagent;Solid;Specificity;T-Lymphocyte;Testing;Therapeutic Effect;tumor

PROJECT_TITLE: Human CD3epsilon co-potentiation to boost immunotherapy


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: Project Narrative Confluent vascular endothelial cells respond to fluid shear stress from blood flow by activating three distinct signaling pathways at cell-cell contacts, but our molecular understanding of these events is limited. This project will test the role of adhesion GPCRs of the latrophilin family in these events, and will use a new DNA origami nanodevice to visualize effects of mechanical tension on conformation of potential mechanosensing proteins. Together, this work will provide a molecular foundation for understanding at unprecedented depth the mechanotransduction processes that are critical in vascular physiology and disease.

PI_NAMEs: LIN, CHENXIANG ;SCHWARTZ, MARTIN A (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adhesions;Adult;alpha-latrotoxin receptor;Area;Arterial Fatty Streak;Arteries;Atherosclerosis;Biochemical;Biology;Blood flow;Blood Vessels;bone morphogenetic protein receptors;cadherin 5;Cardiac;Cell Line;Cells;Collaborations;conformational conversion;Cryoelectron Microscopy;Cytoskeleton;Data;Development;Devices;Diameter;Disease;DNA;Elements;Embryonic Development;Endoglin;Endothelial Cells;Endothelium;Event;experimental study;Extracellular Domain;Family;Foundations;G-Protein-Coupled Receptors;Genes;Heart Valves;In Vitro;in vivo;Inflammation;Intercellular Junctions;KDR gene;Knock-out;Lead;Learning;Liquid substance;lymphatic valve;malformation;Mammals;mechanical force;mechanical load;Mechanics;Mechanoreceptors;mechanotransduction;Mediating;Mediator;Medicine;member;Modeling;Molecular;Molecular Conformation;Mus;Myosin ATPase;nanodevice;Nanotechnology;notch protein;novel;Pathway interactions;Pattern;PECAM1 gene;Physiological;Physiology;Play;postnatal;Predisposition;Process;protein complex;Protein Conformation;Proteins;Publishing;response;Role;shear stress;Signal Pathway;Signal Transduction;Specific qualifier value;Testing;Trees;Vascular Endothelial Cell;Visualization;Work

PROJECT_TITLE: Fluid shear stress mechanotransduction at endothelial cell-cell junctions

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Lung;Lung Cancer;Patient Safety

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The work described in this application has the fundamental goal of supporting cancer clinical research in a broad patient population and is thus of direct relevance to the National Cancer Institute’s goal of advancing scientific knowledge and helping all people to live longer, healthier lives. Dr. Doroshow’s work as EDDOP PI and LUNG MAP substudy co-chair will increase Mount Sinai participation in ETCTN and NCTN early phase clinical trials and offer more patients the opportunity to receive potentially effective novel therapies for advanced cancers. Her leadership in these areas will also be of benefit to trainees and junior investigators, helping them to develop patient-centered, innovative clinical trial portfolios.

PI_NAMEs: DOROSHOW, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Administrative Supplement;Advanced Malignant Neoplasm;Area;Cancer Therapy Evaluation Program;career;Center Core Grants;Characteristics;Clinical Investigator;Clinical Investigator Award;Clinical Research;clinical trial participant;Clinical Trials;Collaborations;Data;Doctor of Philosophy;drug development;early phase clinical trial;Early Therapeutic-Clinical Trials Network;Educational workshop;ERBB2 gene;Faculty;Genomics;Goals;Grant;Hematology;Histology;improved;Incubators;Individual;innovation;Institution;investigator-initiated trial;Knowledge;Leadership;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncologist;Medical Oncology;medical schools;member;Monitor;National Cancer Institute;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncology;oncology trial;Participant;patient oriented;patient population;Patients;Persons;Phase;Principal Investigator;Research;Research Personnel;Review Committee;Role;Safety;Scientific Advances and Accomplishments;Southwest Oncology Group;Thoracic Oncology;Trastuzumab;Work

PROJECT_TITLE: TCI Early Career Cancer Clinical Investigator Award


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Breast cancer is the most common cancer worldwide and is the leading cause of cancer death in women. The goal of this project is to support Dr. Nusayba Bagegni's goal to design and lead NCI-funded breast cancer therapeutic trials and facilitate clinical research education and training in clinical drug development. Her mission is to contribute to lessening the burden of breast cancer, with a focus on aggressive breast cancer subtypes, by designing and leading therapeutic clinical trials.

PI_NAMEs: EBERLEIN, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Address;advanced breast cancer;aggressive breast cancer;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Etiology;cancer subtypes;career;Clinical;Clinical Drug Development;Clinical Investigator;Clinical Research;Clinical Trials;design;Developmental Therapeutics Program;Funding;Goals;improved;interest;Intervention;investigator-initiated trial;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mission;Monitor;novel therapeutic intervention;Outcome;Phase;predictive marker;Research Activity;Research Training;Resistance;response biomarker;Site;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;Therapy trial;Training and Education;Treatment Efficacy;Underrepresented Minority;Universities;Washington;Women's mortality

PROJECT_TITLE: Cancer Center Support Grant


ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: This is a supplement application for Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP) funding for the following SWOG Cancer Research Network studies: S1608, S1803, S1827, S2114, S2212, S2306 and S2312 (NEW) . Additionally, this request contains the progress reports for the following additional studies: S1418, S1602, S1612, and S1826.

PI_NAMEs: BLANKE, CHARLES D. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Biological Markers;Cancer Research Network;Funding;Image;programs;Progress Reports;Quality of life;Southwest Oncology Group

PROJECT_TITLE: SWOG NCTN BIQSFP Supplement for GY11


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: OVERALL - Project Narrative Individuals who identify as Latino/Hispanic, LGBTQ+, of low socio-economic status, who live in rural communities, youth, and immigrants and refugees, are among those who suffer more from a variety of health conditions. Minority-serving institutions are uniquely positioned to foster innovative and impactful minority health and health disparities research given their commitment to the communities they serve. Given its scientific expertise, SDSU and SDSU Imperial Valley, and by extension, the SDSU HealthLINK Center for Transdisciplinary Health Disparities Research, are ideally suited to expand efforts to build institutional, investigator, and partner capacity to engage in innovative basic biomedical, behavioral/population, and clinical/health services research and reduce health disparities.

PI_NAMEs: AYALA, GUADALUPE X;WELLS, KRISTEN JENNIFER (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Area;Behavioral;Biology;Biomedical Research;California;career;career development;Clinical;Collaborations;Communities;community engaged research;community engagement;community partners;Consent;Consultations;cost;County;Coupled;Data;Data Science;Development;Discipline;Doctor's Degree;Educational workshop;Environment;Ethics;evidence base;Evidence based practice;Extramural Activities;Faculty;Fostering;Foundations;Funding;Goals;Grant;Growth;Health;health determinants;Health Disparities Research;health equity promotion;health inequalities;Health Promotion;health science research;Health Services;Health Services Research;Hispanic;Human Subject Research;Immigrant;implementation science;improved;Individual;Industry;Infrastructure;innovation;Institution;institutional capacity;Intervention;Investments;Knowledge;Latino;Lesbian Gay Bisexual Transgender Queer;Letters;low socioeconomic status;member;Methods;Mexico;minority health;minority health disparity;Minority-Serving Institution;National Institute on Minority Health and Health Disparities;Participant;Pilot Projects;Policies;Population;Population Research;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;Progress Reports;Psychology;Public Health;recovery services;recruit;Reduce health disparities;Refugees;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;response;Rural;Rural Community;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Services;skills;Specialized Center;STEM research;Strategic Planning;success;System;tool;Training;Training Programs;Transcend;Translating;Translational Research;Translations;United States National Institutes of Health;Universities;uptake;Writing;Youth


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: AYALA, GUADALUPE X (contact)

PROJECT_TERMS: Address;Advisory Committees;Area;Behavioral;career;Clinical;Clinical Research;Collaborations;Communication;Communities;community engaged research;community engagement;community partners;Complement;cost;County;Data;Development;Environment;environmental change;Equipment;ethnic identity;Evaluation;evidence base;Evidence based intervention;Evidence based practice;experience;Extramural Activities;Faculty;Fostering;Funding;Gender Identity;Geography;Goals;Guidelines;Health;Health Disparities Research;health disparity;Health Services;Health Services Research;Human Resources;improve minority health;improved;Individual;Infrastructure;innovation;Institution;institutional capacity;Knowledge;Leadership;Measures;meetings;member;Mentors;Methods;minority health;minority health disparity;Modeling;Organizational Efficiency;Outcome;Peer Review;Persons;Play;Policies;policy implication;Population;programs;Publications;racial identity;recovery services;recruit;Reduce health disparities;Research;Research Personnel;Research Support;research to practice;Resources;response;Role;rural dwellers;satisfaction;scale up;Science;Services;sexual identity;Socioeconomic Status;Specialized Center;Structure;success;System;Teacher Professional Development;tool;Training Programs;Translations;U-Series Cooperative Agreements;United States National Institutes of Health;uptake

PROJECT_TITLE: The Administrative Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WELLS, KRISTEN JENNIFER (contact)

PROJECT_TERMS: analytical method;Area;Behavioral;biobehavior;career;Clinical;Collaborations;Collection;Common Data Element;Communication;Communities;community collaboration;community engaged research;community engagement;community partners;Consultations;cost;Data;Data Analytics;data collection evaluation;Data Science;data sharing;design;Development;dissemination science;Ecological momentary assessment;Educational workshop;Ethics;Event;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;Health;Health Disparities Research;health science research;Health Services Research;Human;Human Resources;implementation evaluation;implementation science;improve minority health;improved;Individual;Infrastructure;innovation;institutional capacity;Intervention;Lead;Linguistics;Measurement;Measures;member;Methods;minority health;minority health disparity;Needs Assessment;novel strategies;Participant;patient engagement;Performance;PhenX Toolkit;Pilot Projects;Population;Procedures;Productivity;programs;Protocols documentation;Readiness;recovery services;recruit;Reduce health disparities;Research;Research Activity;research and development;Research Ethics;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;response;sensor;Services;skills;Specialized Center;Strategic Planning;Surveys;Technology;theories;tool;Training;Training Programs;Translations;Universities;wireless sensor;Work;Writing;Youth

PROJECT_TITLE: The Research Capacity Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities Research


PROJECT_TERMS: Award;Behavioral;career;career development;Career Mobility;Clinical;Collaborations;Communities;community partners;Coupled;Data;Data Set;design;Development;dissemination strategy;Educational workshop;Endowment;Environment;Evaluation;Faculty;Feedback;Fostering;Funding;Goals;Grant;Growth;Health;Health Disparities Research;health science research;Health Services;Health Services Research;implementation measures;implementation science;improved;Individual;Infrastructure;innovation;Institution;institutional capacity;Journals;Knowledge;Measures;member;Mentors;Methods;minority health;minority health disparity;Modeling;National Institute on Minority Health and Health Disparities;Newsletter;Outcome;outreach;Peer Review;Persons;Pilot Projects;Population;Postdoctoral Fellow;Process;programs;Qualifying;recruit;Request for Proposals;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;satisfaction;Science;Scientist;Services;skills;social media;Specialized Center;tool;Training;Training Programs;web site;Work;Writing

PROJECT_TITLE: The Investigator Development Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: GOMBATTO, SARA P (contact)

PROJECT_TERMS: Achievement;Address;Agreement;Border Community;Budgets;California;career;Collaborations;Communities;community academic partnership;community center;community collaboration;community engaged approach;community engaged research;community engagement;community involvement;community partners;County;data sharing;Development;Disparity;Educational workshop;Ensure;Evaluation;Evidence based practice;Faculty;Family health status;Feedback;Fostering;Funding;Goals;Grant;Guidelines;Health;Health Disparities Research;health disparity;health equity promotion;Health Promotion;Human;Immigrant;Individual;innovation;institutional capacity;Knowledge;Latino Population;Lead;Lesbian Gay Bisexual Transgender Queer;Logic;low socioeconomic status;marginalized population;member;Mentorship;Methods;Mexico;minority health;minority health disparity;Modeling;Organizational Policy;Participant;Persons;Pilot Projects;Policies;Preparation;Procedures;Process;Readiness;recruit;Refugees;Research;Research Ethics;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resources;response;Rural;Rural Community;rural setting;Services;Specialized Center;success;tool;Training;Training Programs;Translating;Translations;Trust;United States National Institutes of Health;uptake;urban setting;Work;Writing;Youth

PROJECT_TITLE: The Community Engagement Core of SDSU HealthLINK Center for Transdisciplinary Health Disparities Research


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PI_NAMEs: RIESTRA, ANGELICA M (contact)

PROJECT_TERMS: Affect;Anti-Bacterial Agents;Atopobium vaginae;Automobile Driving;Bacteria;Bacterial Vaginosis;Black race;black women;catalyst;Cell Death;cell injury;Cell membrane;Cells;cervicovaginal;Classification;Clathrin Light Chains;Clinical;Communities;comorbidity;Confocal Microscopy;Country;cytokine;Data;Development;disease disparity;Electron Microscopy;Epithelial Cells;Epithelium;ethnic minority;extracellular;FDA approved;Female;female reproductive tract;Future;Generations;Health;Health Disparities Research;health disparity;health inequalities;Human;immunoregulation;Indirect Fluorescent Antibody Technique;Infection;infection risk;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;insight;Knock-out;Knowledge;Lactobacillus;Latina;live cell imaging;Malignant neoplasm of cervix uteri;Mediating;Microbe;microbial community;Modeling;Molecular;Morbidity - disease rate;N-terminal;neglect;Not Hispanic or Latino;novel;Parasites;Parasitic infection;Pathogenesis;Phagocytosis;pharmacologic;Pilot Projects;Predisposition;Pregnancy Outcome;Prevalence;Process;Production;Proteins;Public Health;racial minority;Recombinants;Research;Research Project Grants;restoration;Risk;Role;Sexual Transmission;Sexually Transmitted Diseases;Signal Transduction;socioeconomics;Stains;targeted treatment;Testing;Therapeutic;Trichomonas Infections;Trichomonas vaginalis;Vagina;White Women;Woman;Work

PROJECT_TITLE: RP-Riestra/Sussman: Investigating the Antibacterial and Immune Modulating Effects of Trichomonas Vaginalis Infection and Pyroptosis


NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SANT, KARILYN ELIZABETH (contact)

PROJECT_TERMS: Air;Air Pollution;air sampling;Antibiotic Resistance;Automobile Driving;Border Community;California;Caregivers;chemical association;Chemicals;Child;Child Care;Child Health;Collection;Communication;Communities;community organizations;community-centered;Complex;contaminated water;Data;Detection;Development;Diffuse;Distant;Economics;Environmental Exposure;environmental justice;Environmental Monitoring;Environmental Risk Factor;Environmental Science;Event;experience;Exposure to;field survey;Focus Groups;Fright;Funding;Hand;Health;Health Disparities Research;hispanic community;Home;Home environment;House Dust;Household;Human;Hurricane;Impairment;implementation barriers;Industrial Waste;Industrialization;Infrastructure;innovation;Intervention;intervention mapping;Interview;Laboratories;Latino;Legal;lens;Low income;Measurement;Measures;member;Metagenomics;Methodology;Methods;Mexico;Microbe;microbial;microbial signature;microbiome;Monitor;Municipalities;Oceans;Odors;Oral;Organism;Pacific Ocean;pathogen;Pathogenicity;Pilot Projects;Poison;pollutant;Pollution;Population Surveillance;Prevention;Public Health;Rain;Recording of previous events;recruit;Reduce health disparities;remediation;Reporting;Research Methodology;Research Project Grants;resistance gene;Risk;risk mitigation;Sampling;Sanitation;Schools;Series;Sewage;Side;Site;social;Source;spatiotemporal;Swab;therapy design;therapy development;Urbanization;wasting;Water;water flow;Work

PROJECT_TITLE: RP-Sant/Quintana: Assessment of Exposure to Microbial and Chemical Pollution in US Community Air from the Binational Tijuana River Watershed


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: VILLODAS, MIGUEL T (contact)

PROJECT_TERMS: access disparities;Address;Administrator;Affect;Attention deficit hyperactivity disorder;Behavior;Behavior Therapy;Behavioral;Calendar;Caregivers;Child;Child Care;Clinical Trials;Cluster randomized trial;Communication;community advisory board;Consultations;County;Data;Data Collection;design;Development;disparity reduction;Ethnic Origin;evidence base;Evidence based intervention;Family;feasibility trial;Feedback;fifth grade;Focus Groups;Future;Goals;Graph;Health Disparities Research;Health Personnel;Health Technology;Home;Hybrids;Impairment;implementation intervention;implementation outcomes;improved;Individual;interest;Intervention;intervention mapping;Interview;Lead;Learning;Life;Link;low socioeconomic status;Mediating;meetings;Mental Health;mHealth;minority children;mobile application;Mobile Health Application;Modeling;Monitor;Online Systems;Outcome;parenting intervention;Parents;Perception;Performance;Persons;Pilot Projects;Population;Practice Management;Process;Program Effectiveness;programs;Protocols documentation;prototype;Provider;racial minority;racial minority population;recruit;Reporting;Research;Research Project Grants;Research Project Summaries;Resources;Role;Rural;rural setting;Schedule;school district;School-Age Population;Schools;Series;Services;skills;skills training;social;social stigma;Socioeconomic Status;Symptoms;Target Populations;teacher;Technology;technology validation;Testing;Time;tool;Training;Transportation;treatment as usual;treatment planning;urban school;usability;Videoconferencing;web app;Work

PROJECT_TITLE: RP-Villodas: Reducing Disparities in Access to Evidence-based Services for ADHD Through Technology


NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The peripheral nervous system (PNS) is highly sensitive to disruption in activity of the proteasome, a protein complex important for degradation and a range of neuronal regulatory activities, but the role of the newly- discovered neuronal membrane proteasome (NMP) in the PNS is uncharacterized. The proposed experiments seek to investigate: (1) the molecular structure of the PNS NMP and its distribution across neuronal plasma membranes; and (2) PNS NMP regulatory activity in sensory neuron subpopulations and pain sensation. This work will provide critical insight into the poorly-understood role of the proteasome in PNS pain signaling and may reveal therapeutic targets for pain reduction or prevention of peripheral neuropathies.

PI_NAMEs: CHURCH, TAYLOR RENNE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acute;Address;Affect;Afferent Neurons;Attenuated;Axon;Axonal Transport;Behavioral Assay;Binding;Biochemical;Biological Assay;Bortezomib;Calcium Signaling;Cell Cycle Arrest;Cell membrane;Cells;Central Nervous System;Characteristics;chemotherapy;Collaborations;Communication;Complex;Confocal Microscopy;Cryoelectron Microscopy;Data;Defect;Dendrites;Detection;Development;Disease;Dose;Electron Microscopy;Electrophysiology (science);experimental study;extracellular;Extracellular Space;Fiber;Foundations;Freezing;Future;Glycoproteins;Goals;Grant;Health;Image;Immunofluorescence Immunologic;in vivo calcium imaging;Individual;Induced Neurons;inflammatory pain;inhibitor;insight;Investigation;Knock-out;Label;Laboratories;Length;light microscopy;Limb structure;Long-Term Potentiation;Macromolecular Complexes;mechanical allodynia;Mechanics;Membrane;MG132;Modality;Modeling;Molecular;Molecular Structure;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;myelination;Nervous System;neuronal cell body;neuronal patterning;Neurons;Neuropathy;neurotoxicity;Nociception;Nociceptors;novel;Numbness;Outcome;Pain;pain reduction;pain sensation;pain sensitivity;pain signal;painful neuropathy;Paracrine Communication;Pathway interactions;Patients;Pattern;Peptide Signal Sequences;Peptides;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Physiological;Play;Prevention;Production;Property;Proprioception;Proteasome Binding;Proteasome Inhibition;Proteasome Inhibitor;protein complex;protein degradation;Proteins;Regulation;Reporter;Research;Role;Sensory;Series;side effect;Signal Transduction;Skin Tissue;somatosensory;Spinal Ganglia;Structure;Synapses;Techniques;Testing;Therapeutic;therapeutic target;Thinness;ultra high resolution;Work

PROJECT_TITLE: The Role of the Neuronal Membrane Proteasome in the Peripheral Nervous System and Pain Sensation


NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: The endothelial surface lines all blood vessels, serving as the nexus between blood and the body, and forming a membrane that directs coagulation and innate immune responses to injury. This project will elucidate mechanisms by which the endothelium detects histones and will test therapeutic strategies to protect the endothelial cells from maladaptive coagulation responses after severe trauma.

PI_NAMEs: FREEMAN, KALEV  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Biology;Blood;Blood flow;Blood Vessels;burden of illness;Clinical;Coagulation Process;Diagnosis;Disease;Endothelial Cells;endothelial dysfunction;Endothelium;Health;Health Care Costs;Histones;Impairment;improved;improved outcome;Inflammation;Injury;Innate Immune Response;Intervention;Membrane;Molecular;molecular modeling;novel strategies;programs;Research;response;response to injury;Role;Signal Transduction;Surface;Syndrome;Testing;therapeutic evaluation;Translating;Trauma;Trauma patient;Vascular Endothelium

PROJECT_TITLE: Molecular Mechanisms of Histone-Induced Endotheliopathy in Trauma

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]