ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Millions of girls are married annually before the age of 18, and despite the lifelong negative consequences for health and the social determinants of health, little is known about how to reduce the prevalence of child marriage. Our study leverages a prior randomized control trial of the uniquely effective Pathways program, which reduced child marriage by 60 percentage point in treatment communities in northern Nigeria. We will conduct a six-year follow up survey with study participants to evaluate the medium-run effects of a successful program to combat child marriage, aiming to contribute important evidence on the health benefits of delaying marriage and inform future interventions.

PI_NAMEs: COHEN-GIDON, ISABELLE  (contact)

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Address;Affect;Age;attenuation;Behavior;boys;Child;Child Health;Childhood;combat;Communities;community-centered;Complex;cost;Cost Effectiveness Analysis;Cost-Benefit Analysis;Data;Data Set;Decision Making;design;Development;early childbearing;Economics;Education;effectiveness evaluation;Effectiveness of Interventions;Evaluation;experimental study;Female Adolescents;Fertility;First Births;follow-up;Future;girls;Health;health assessment;Health Benefit;health determinants;health disparity;improved;Incidence;Intervention;intervention effect;intimate partner violence;knowledge base;Laws;Learning;Life Cycle Stages;low and middle-income countries;Marriage;Marriage Ages;maternal morbidity;Maternal Mortality;Measures;men;Mental Depression;multi-component intervention;National Institute of Child Health and Human Development;Nigeria;novel;Outcome;Participant;Pathway interactions;Policies;poor health outcome;post intervention;Pregnancy;pregnancy health;prepregnancy;Prevalence;prevent;Program Effectiveness;programs;Randomized;Randomized, Controlled Trials;recruit;Reproduction;Resource-limited setting;Respondent;Risk;Running;Self Assessment;sexual debut;Sexually Transmitted Diseases;social;social health determinants;Social support;Strategic Planning;Structure;successful intervention;Surveys;transition to adulthood;Translating;Update;Vocation;Vocational Education;women's outcomes;young woman

PROJECT_TITLE: Evaluating the effects of an intervention against child marriage: Six year follow-up

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: TEMPE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Falls represent an enormous burden for people with PD, leading to injury, isolation, and death. Physical therapy is incompletely effective at reducing falls, due in part to a lack of knowledge regarding which aspects of balance clinicians should target during therapy to reduce falls and the brain regions that underlie these deficits. This project will fill these knowledge gaps by identifying the specific aspects of reactive balance and standing sway that are related to prospective falls and their neural signatures, thus improving clinicians’ ability to treat people with PD at risk for falls.

PI_NAMEs: PETERSON, DANIEL SOREN (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Area;Attention;Awareness;base;Brain;Brain region;Brain Stem;Cessation of life;Clinical;Clinical Trials;cohort;Complement;Data;design;Diffusion Magnetic Resonance Imaging;Effectiveness;Equilibrium;experience;Fall prevention;fall risk;falls;follow-up;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Goals;improved;Individual;Injury;Intervention;Knowledge;Length;Logistic Regressions;Measures;Mediating;Modeling;Monitor;neural;neural correlate;neuroimaging;neuromechanism;No Evidence of Disease;novel;Outcome;outcome prediction;Parkinson Disease;Patients;Persons;Physical therapy;Posture;Prevention therapy;preventive intervention;prospective;Protocols documentation;Quality of life;Regression Analysis;Rehabilitation therapy;Research;response;Speed;Testing;Thinness;Time;Weight;Work

PROJECT_TITLE: Identifying Targets for Fall-prevention Rehabilitation in People with Parkinson’s Disease

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: OH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: ATHENS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative Interdisciplinary graduate training in Occupational Safety (OS) and Occupational Health Psychology (OHP) are critical to meet NIOSH goals to advance Total Worker Health® research and practice. Researchers and practitioners with broad content knowledge, state-of-the-art research skills, and interdisciplinary teamwork experience are needed to protect the health and safety of workers while advancing their wellbeing. The proposed expansions to the existing successful OS training program will produce researchers and practitioners to meet these goals.

PI_NAMEs: YUAN, TAO  (contact)

PROJECT_TITLE: Ohio University Training Project Grant in Occupational Safety


ORG_CITY: SITKA

ORG_NAME: ALASKA MARINE SAFETY EDUCATION ASSN

ORG_STATE: AK

PHR: PROJECT NARRATIVE J. DZUGAN This project has critical relevance to one of the nation’s highest risk occupations the nation: Alaska commercial fishing. This project will continue to support Coast Guard required safety training in the prevention and effective response to both commercial fishing vessel disasters and falls overboard, as well as develop a distance education methodology to reduce musculoskeletal disorders (MSDs) to upper extremities due to repetitive motion, the most common cause of injuries in this occupation. This work will be accomplished by maintaining and supporting an Alaska port based marine safety instructor network to deliver training statewide and develop a web based ergonomics training platform specific to commercial fishing MSDs.

PI_NAMEs: CYR, LEANN FAY (contact)

PROJECT_TITLE: Commercial Fishing Safety Training


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: WALTHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Public Health Relevance Numerous therapeutic molecules and small-molecule biological probes are synthetic agents and many of them contain at least one nitrogen atom; therefore, the subject of this proposaldiscovery of novel synthetic methods for efficient synthesis of these nitrogen- containing molecules will advance drug discoveries as well as the basic biomedical and clinical research.

PI_NAMEs: XU, HAO  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Alkenes;Amination;Biological;Biology;Biomedical Research;Carbohydrates;Catalysis;Chemicals;Clinical Research;Complex;drug discovery;functional group;glycosylation;Goals;Ions;Iron;Label;Metals;Methods;Molecular;Nitrogen;novel;Organic Synthesis;Pharmaceutical Chemistry;programs;public health relevance;Reaction;Research;Science;Series;small molecule;Synthesis Chemistry;Temperature;Therapeutic;tool

PROJECT_TITLE: Selective Nitrogen Atom Transfer for Applications in Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Hematopoietic stem cells (HSCs) are an extremely valuable therapeutic cell type due to their capacity to reconstitute the entire blood system upon transplantation or injury. Recent research has identified transcription factor combinations that reprogram endothelial cells to HSCs, but the mechanisms underlying this process remain unknown. Here, we propose to elucidate the molecular and cellular mechanisms by which reprogramming factors promote cell fate changes, laying the groundwork for more selective and efficient generation of clinically relevant HSCs.

PI_NAMEs: CHRONIS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: ATAC-seq;Autoimmune Diseases;Binding;Blood;Blood Cells;Blood Vessels;Cell Reprogramming;cell type;Cells;Characteristics;Chromatin;Clinical;clinically relevant;comparative;curative treatments;Data;Development;Disease;DNA Sequence;Endothelial Cells;endothelial stem cell;Endothelium;Enhancers;Epigenetic Process;Event;experimental study;FOSB gene;Frequencies;Gene Expression Profile;gene regulatory network;Generations;Genes;Genetic;GFI1 gene;Goals;Graft Rejection;graft vs host disease;Growth;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell expansion;hematopoietic stem cell fate;Hematopoietic Stem Cell heterogeneity;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;hemogenic endothelium;Homeostasis;Homologous Transplantation;In Vitro;in vivo;Individual;Injury;insight;intercellular communication;Link;Maintenance;Mammalian Cell;Measurement;Mediating;Molecular;mouse model;multiple omics;novel;novel strategies;Patients;Persons;Physiological;pluripotency;Population;Process;Production;programs;reconstitution;Research;Risk;RUNX1 gene;Seminal;Signal Pathway;Signal Transduction;Site;Somatic Cell;Source;SPI1 gene;stem cell genes;stem cell population;stem cell therapy;System;Therapeutic;Tissues;transcription factor;Transgenic Mice;Transplantation;Umbilical Cord Blood;Validation

PROJECT_TITLE: Reprogramming Gene Regulatory Networks to a Hematopoietic Stem Cell State

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Enzymes using metal centers and/or organic radicals play many crucial roles in the fundamental biochemistry of human health, with deficiencies in their bioassembly or enzymatic functions associated with various diseases. The R. David Britt laboratory is using advanced spectroscopic techniques to understand the assembly and catalytic mechanism of a number of such metal and radical centers. The ultimate goal is to bring this enhanced knowledge of fundamental metallobiochemistry to the treatment of diseases and the enhancement of human health.

PI_NAMEs: BRITT, R DAVID (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Spectroscopic Investigations of Metalloenzyme Mechanisms


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative  Neurotropic flaviviruses, including Zika virus, are a growing threat to global health. Despite the increasing burden of neurologic injury and cognitive impairment associated with flavivirus encephalitis, no disease-specific therapies for these infections exist. Here, we aim to identify new molecular mechanisms that promote protective neuroimmune function during Zika virus infection of the brain. These findings would uncover much-needed new molecular targets for the development of therapeutic and intervention strategies.

PI_NAMEs: DANIELS, BRIAN  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Apoptosis;Astrocytes;Biological;Blood Vessels;Brain;Brain region;Cell Death;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Central Nervous System Viral Diseases;Chemotactic Factors;Complex;Data;Disease;Elements;Encephalitis;experimental study;Flavivirus;Gene Expression;Genetic;Genetic Transcription;global health;Immune;immune function;Immune signaling;immunopathology;Impaired cognition;in vivo;Infection;Infiltration;Inflammation;Inflammatory;Intervention;Kinetics;Leukocytes;Metabolic;migration;Molecular;Molecular Biology;Molecular Target;mouse genetics;Necrosis;Nerve Degeneration;Nervous System Trauma;neural;Neuroglia;Neuroimmune;neuroinflammation;neurotoxic;neurotropic;novel;Output;overexpression;pathogen;Pathogenicity;Pathologic;Pathway interactions;Process;programs;Protein Kinase Interaction;Proteomics;Publishing;Receptor Activation;Receptor-Interacting Protein;recruit;RIPK3 gene;Role;Signal Transduction;Signaling Molecule;System;Testing;therapeutic development;Time;tool;Transcript;transcriptomics;Viral;Viral Encephalitis;Viral Load result;Viral Physiology;Virus Diseases;Virus Replication;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Investigating astrocytic RIPK3 as a driver of protective neuroinflammation during viral encephalitis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Immunology is the study of the body’s immune system and how it responds in states of health and disease. Many human conditions involve alterations of the normal function of the immune system including cancer, autoimmune diseases, infectious diseases, and transplantation. The purpose of this training grant is to instruct the next generation of scientists in the critical thinking and technical skills necessary to provide mechanistic insights into how the immune system functions, and how to manipulate the host immune response to the benefit of human health.

PI_NAMEs: MOORE, BETHANY B. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Research Training

PROJECT_TITLE: Research Training in Experimental Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PHILADELPHIA

ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

ORG_STATE: PA

PHR: Cardiovascular disease (CVD) is the leading causal of morbidity and mortality in the United States. Veterans are at higher risk than the general population and CVD is the number one cause of hospitalizations in the VA. Atherosclerosis, narrowing of arteries due to plaque, causes CVD. It affects the coronary arteries of the heart causing heart attack, the peripheral arteries of the leg causing debilitating leg pain and gangrene, and the carotid arteries leading to the brain causing stroke. Current approaches to prevent and treat CVD treat all forms of atherosclerosis the same. Genetic studies of coronary and peripheral artery disease have identified important differences, suggesting a tailored approach will work better. Similar studies for carotid artery disease are lacking, which prevents the full implementation of precision medicine approaches. The proposed study will use data from the VA Million Veteran Program to identify genes associated with carotid stenosis and quantify the impact of known and novel risk factors. It will help establish tailored therapy to treat carotid stenosis and prevent stroke.

PI_NAMEs: DAMRAUER, SCOTT MICHAEL (contact)

PROJECT_TERMS: Address;Affect;Algorithms;Arteries;Atherosclerosis;Biological Markers;Biology;blood lipid;Blood Pressure;Blood Vessels;Brain;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Arteries;Carotid Artery Diseases;Carotid Artery Plaques;Carotid Atherosclerotic Disease;Carotid Stenosis;Cerebrovascular Disorders;clinically significant;Coronary Arteriosclerosis;Coronary artery;Coronary heart disease;Data;Data Scientist;Development;Diabetes Mellitus;Disease;Disease Progression;Disease susceptibility;disorder subtype;Drug Targeting;Electronic Health Record;end stage disease;Epidemiologist;Equation;experimental study;Gangrene;General Population;Genes;Genetic;genetic architecture;Genetic Risk;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Guidelines;Health;health data;Heart;high risk;Hospitalization;Image;improved;individualized medicine;Intervention;Ischemic Stroke;Knowledge;Leg;Life Style;Link;Measures;Mediation;Mendelian randomization;Military Personnel;Modeling;modifiable risk;Modification;Morbidity - disease rate;mortality;Myocardial Infarction;Natural Language Processing;new therapeutic target;novel;Obesity;Outcome;Pain in lower limb;Pathway interactions;Peripheral;Peripheral arterial disease;personalized approach;Pharmaceutical Preparations;precision medicine;Predisposition;prevent;Prevention;Prevention approach;Prevention Guidelines;Primary Prevention;programs;Reporting;Risk;Risk Factors;risk prediction;risk variant;Role;Sample Size;Secondary Prevention;Severities;Smoking;statistics;Stenosis;Stroke;Stroke prevention;System;Therapeutic;Therapeutic Intervention;therapeutic target;Thick;Time;trait;United States;Veterans;Work

PROJECT_TITLE: Leveraging  the Genetics of carotid stenosis for identifying novel risk factors and therapeutic opportunities


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

ORG_CITY: CHARLESTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE South Carolina Biomedical Data Science and Informatics for Health Equity Research (SC BIDS4HEALTH) training program combines rigorous curriculum in biomedical informatics, data science, population, health systems and policy, and domain biology based on existing joint PhD degree in Biomedical Data Science and Informatics with coursework and practical experiences in understanding diversity and career readiness skills. The training program includes predoctoral and postdoctoral components. The faculty mentors in the program are nationally and internationally recognized leaders in biomedical informatics, public health, computer science and engineering and multiple biomedical and health domains.

PI_NAMEs: ALEKSEYENKO, ALEXANDER V (contact);DEAN, BRIAN

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Affect;biomedical data science;biomedical informatics;career;Caring;Chronic Care;Chronic Disease;Communities;computer science;critical access hospital;Data Science;Data Scientist;Development;didactic education;Disparity;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;eHealth;Engineering;experience;Faculty;Foundations;Health;health care quality;health disparity;Health equity research;Health Services;Health system;Healthcare;Historically Black Colleges and Universities;Improve Access;improved;Individual;Informatics;informatics tool;innovation;International;interoperability;Joints;Length;Measurable;Medical;medically underserved;Modeling;novel;Outcomes Research;Pathway interactions;Patients;population health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Public Health;Public Health Informatics;Research;Research Training;Resources;Risk;Rural;Rural Population;South Carolina;Students;telehealth;Training;Training Programs;Underserved Population;Universities

PROJECT_TITLE: SC Biomedical Informatics & Data Science For Health Equity Research Training (SC BIDS4HEALTH)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: MADISON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE – New treatments for anxiety disorders are critically needed and a more complete understanding of pathological anxiety at the molecular, cellular and circuit levels will provide a foundation for new treatment development. Using our non-human primate model of extreme anxiety, the proposed studies will use neuroimaging, molecular sequencing techniques and chemogenetics to understand the extent to which neurons in the dorsolateral prefrontal cortex are involved in the expression of early-life pathological anxiety and could serve as treatment targets for anxiety disorders. Additionally, these studies will serve as a proof-of-concept to understand the feasibility of developing chemogenetic approaches for the modulation of prefrontal cortical function in the treatment of severe and refractory psychiatric disorders.

PI_NAMEs: KALIN, NED H (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;anxious temperament;Behavior assessment;behavioral phenotyping;Brain;Cell Nucleus;cell type;Child;Childhood;Chronic;cognitive control;Cognitive Therapy;Confocal Microscopy;Control Animal;Coupling;Data;designer receptors exclusively activated by designer drugs;Development;Down-Regulation;effective therapy;Electron Microscopy;emotion regulation;Equilibrium;experimental study;Foundations;Gene Delivery;Gene Expression;Gene Expression Profile;Gene Mutation;Genes;Genetic;genetic approach;Genetic Risk;Glucocorticoids;Glutamates;Human;improved;insight;Investigation;Laboratories;Lasers;Life;Mediating;Mediator;Mental Depression;Mental disorders;Metabolic;Metabolism;Methods;Modeling;Molecular;Multimodal Imaging;multimodal neuroimaging;neural circuit;neuroimaging;Neuronal Plasticity;Neurons;neuroregulation;nonhuman primate;Nuclear RNA;Pathological anxiety;Pathway interactions;Phenotype;Prefrontal Cortex;Primates;Psychopathology;Refractory;repetitive transcranial magnetic stimulation;Research;Risk;Risk Factors;Role;Short-Term Memory;Stress;System;Techniques;Testing;therapy development;Tissues;transcriptome sequencing;treatment of anxiety disorders;Viral Vector

PROJECT_TITLE: Brain Mechanisms Mediating Genetic Risk for Anxiety and Depression

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: LA JOLLA

ORG_NAME: CELLARCUS BIOSCIENCES INC

PHR: Narrative To meet the needs of cancer researchers investigating the role of extracellular vesicles in cancer we will develop and validate assay kits that enable the high-resolution measurement of EV number, size, and surface cargo. These assays will enable researchers to study the roles of EVs in the pathology and response to cancer. Such studies may lead to the development of new biomarkers to assess cancer type and target and monitor treatment.

PI_NAMEs: NOLAN, JOHN P (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Antibodies;Antibody Affinity;Antibody Specificity;Automation;Biogenesis;Biological Assay;Biological Markers;Biological Process;Biological Sciences;biomarker panel;Biotechnology;Blood;Brain;cancer type;Cancerous;Cell Line;Cells;Cerebrospinal Fluid;Client;Collaborations;Color;Complex;Controlled Environment;Cryoelectron Microscopy;Data;design;detection limit;Development;Diagnosis;diagnostic biomarker;Distant;Engineering;extracellular vesicles;Feedback;Flow Cytometry;Fluorescent Antibody Technique;Heterogeneity;Immunoassay;improved;interest;Laboratories;liquid biopsy;Malignant Neoplasms;Measurement;Measures;Medical center;Membrane Proteins;Methods;Monitor;Monoclonal Antibodies;Neoplasm Metastasis;neoplastic cell;Optics;Organ;Pathology;Performance;Phase;Plasma;potential biomarker;Preparation;Production;Reagent;Recurrence;Reporting;Reproducibility;Research;Research Personnel;Resolution;response;Role;Sampling;Services;Site;Standardization;Surface;Technology;Test Result;Testing;therapeutic biomarker;Time;Tissues;tool;Tumor Markers;tumor progression;Urine;Validation;Vesicle;vesicular release;Work

PROJECT_TITLE: Quantitative Analysis of Cancer-associated EVs


ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: More than 200,000 veterans have moderate to severe chronic kidney disease (CKD). People CKD will die prematurely from cardiovascular disease (CVD) or progress to end stage renal disease (ESRD). The two most common causes of CKD are hypertension and diabetes. However, great variability exists in both the severity of risk factors and the response to therapies, limiting the full potential benefit of therapy on individual and population levels. In this proposal we apply what we have learned from the genetics of CKD, hypertension and resistant hypertension in the MVP and apply it to inform risk stratification equations and stratification base on clinical response to treatments. Finally we study the genetic determinants of phosphorus and vitamin D important risk factors for progression of disease, something that our patients struggle with. We hope to be able to improve the health and care provided to our patients.

PI_NAMEs: HUNG, ADRIANA  (contact)

PROJECT_TERMS: adenoma;Adrenal Glands;Adult;Affect;African American population;Age;Albumins;Albuminuria;Aldosterone;base;Bicarbonates;Blood Pressure;blood pressure control;Calcium;Candidate Disease Gene;Cardiovascular Diseases;Caring;Cessation of life;Chronic Kidney Failure;Clinical;clinical predictive model;clinical risk;cohort;Computerized Medical Record;Creatinine;Data;Development;Diabetes Mellitus;Disease Progression;disorder risk;DNA Repository;Early Diagnosis;Early Intervention;Early treatment;End stage renal failure;Equation;Ethnic Origin;Event;fibrillin-2;Future;Gene Expression;Genes;Genetic;Genetic Determinism;genetic information;Genetic Polymorphism;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genome wide association study;genome-wide;Glomerular Filtration Rate;Goals;Health;Hydrochlorothiazide;Hypertension;Hypokalemia;improved;Individual;inorganic phosphate;Kidney Diseases;Knowledge;Learning;Link;Metabolic Diseases;Metabolism;Minerals;Mission;Modeling;multidisciplinary;Mutation;new therapeutic target;novel;Participant;Pathway interactions;Patients;Performance;personalized care;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacogenomics;Pharmacotherapy;Phenotype;Phosphorus;polygenic risk score;Population;Populations at Risk;Potassium;precision medicine;predictive modeling;predictive tools;premature;Prevalence;prevent;Prevention;Primary Hyperaldosteronism;programs;Publishing;Relaxin;Resistant Hypertension;response;Risk;Risk Factors;risk prediction;risk prediction model;risk stratification;RXFP2 gene;Series;Serum;Severities;Severity of illness;sex;Stratification;Testing;thiazide;trait;Translating;treatment response;Uric Acid;Variant;Veterans;Vitamin D;Work

PROJECT_TITLE: Genetics of CKD and Hypertension-Risk Prediction and Drug Response in the MVP


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: PROJECT NARRATIVE  Lung cancer is the leading cause of cancer-related death amongst U.S. Veterans. Despite recent advances in cancer immunotherapy, many patients with NSCLC do not respond to immune checkpoint inhibitors (ICI). Therefore, there is a critical need for the development of novel strategies that enhance the efficacy of immunotherapy. One approach is to utilize in situ vaccination (ISV) with rationally engineered cytokine-secreting dendritic cells (DCs) to generate broad tumor-specific T cell responses. In preclinical studies, we have shown that ISV with FLT3L-secreting conventional type 1 DCs (FLT3L-cDC1) synergize with ICI to eradicate highly aggressive immune-resistant NSCLC. This proposal seeks to elucidate the molecular mechanisms of ISV and DC immunobiology in murine NSCLC models to facilitate the development of novel vaccine therapies for Veterans with lung cancer.

PI_NAMEs: SALEHI-RAD, RAMIN  (contact)

PROJECT_TERMS: Address;Adverse event;Affect;Age;anti-PD-1;Antibodies;Antigen Presentation;antigen-specific T cells;Antigens;Apoptotic;authority;Autologous;Automobile Driving;beta Chain Antigen T Cell Receptor;Bioinformatics;Cancer Etiology;cancer immunotherapy;cancer infiltrating T cells;Cancer Model;career development;CCL21 gene;CD8-Positive T-Lymphocytes;Cell secretion;Cell Survival;Cells;Cellular immunotherapy;Cessation of life;checkpoint inhibition;chemokine;Clinical;Clinical Sciences;clinical translation;Clinical Trials;clinically relevant;Combined Modality Therapy;congenic;Cross Presentation;CXCR6 gene;cytokine;Cytokine Gene;Data;Data Scientist;Dendritic Cell Vaccine;Dendritic Cells;Dependence;Development;Disease;Doctor of Philosophy;draining lymph node;Engineering;Ethics;Evaluation;Evolution;exome sequencing;experience;Flow Cytometry;FLT3 gene;FLT3 ligand;Funding;Gene Expression Profiling;Gene Modified;Goals;Grant;Health system;Healthcare Systems;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immunobiology;Immunofluorescence Immunologic;Immunologic Memory;Immunologic Sensitization;Immunology;Immunophenotyping;Immunosuppression;Immunotherapy;improved;In complete remission;in situ vaccination;In Vitro;in vivo;Incidence;Injections;innovation;Institution;interest;International;K-Series Research Career Programs;Ligands;Los Angeles;Malignant neoplasm of lung;Manuscripts;Mediating;Mediator;Mentors;military veteran;Molecular;mouse model;Mus;Mutation;Natural Killer Cells;Nature;neoantigens;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel vaccines;partial response;Pathway interactions;patient subsets;Patients;pembrolizumab;phase I trial;Phenotype;Physicians;Population;preclinical study;Preparation;programmed cell death ligand 1;Proteins;PTPRC gene;rational design;Refractory;Research;resistance mechanism;response;restoration;Role;Scientist;single-cell RNA sequencing;Spleen;Stable Disease;stem;STK11 gene;Survival Rate;synergism;T cell clonality;T cell response;T-Cell Activation;T-cell receptor repertoire;T-Lymphocyte;tertiary lymphoid organ;Therapeutic;trafficking;Training;transcriptome sequencing;Translational Research;translational research program;tumor;Tumor Antigens;Tumor Immunity;tumor immunology;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes;vaccine evaluation;Vaccine Therapy;Vaccines;Veterans;Writing

PROJECT_TITLE: Flt3l gene-modified cDC1 in situ vaccination in NSCLC: mechanisms and therapeutic application


NIH_SPENDING_CATS: Aging;Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Eating disorders affect 14.4 million women and 6.6 million men in the US, costing the US economy $64.7 billion annually. The long-term objectives of this project are to evaluate whether we are making progress in reducing the public health burden associated with eating disorders, determine the course of eating pathology over adult development, and identify predictors of course that can be translated into targets for intervention, including what to modify, in whom, and when. Findings will establish a benchmark against which to measure progress and advance efforts to eliminate these serious mental disorders.

PI_NAMEs: KEEL, PAMELA K. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adolescence;Adult;Affect;Age;age difference;age effect;age group;Alcohols;Anorexia Nervosa;baby boomer;Behavior Disorders;Benchmarking;Binge eating disorder;Birth;Body Image;Body mass index;Bulimia;Childbirth;cohort;college;comorbidity;cost;Data;Data Collection;design;Development;Developmental Course;Diagnosis;Diagnostic;diagnostic criteria;dieting;Dimensions;distrust;DSM-IV;DSM-V;Eating Disorders;eating pathology;Economic Burden;economic evaluation;Ensure;Epidemiology;epidemiology study;Equipment and supply inventories;ethnic minority population;Ethnic Origin;Exercise;experience;follow-up;Fright;Funding;Gender;gender difference;Generations;Height;Incentives;insight;Intervention;Interview;Investigation;Life;Link;longitudinal course;Longitudinal Studies;Measures;meetings;men;Menopause;Methods;middle age;National Institute of Mental Health;Participant;Patient Self-Report;Persons;Phase;Population;Prevalence;psychosocial;Public Health;purging disorder;Race;racial minority population;Random Allocation;Recording of previous events;recruit;Reporting;reproductive;Role;Running;Sampling;severe mental illness;sex;Standardization;Structure;suicidal;Surveys;Symptoms;Thinness;Translating;Trust;undergraduate student;Universities;university student;Variant;Weight;Woman

PROJECT_TITLE: Eating Disorders Across Genders, Generations, and Adult Developmental Stages

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Mental Health

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This program will provide innovative and comprehensive predoctoral research training at the intersection of clinical translational science and the Research Domain Criteria using a dual mentorship model. Six NIH and two institutionally-funded psychological and brain science trainees per year will receive structured applied experiences, didactics, seminars, and workshops from both core and “stretch” faculty with a specific focus on the development of a clinical translational program of research, grant writing, and professional development.

PI_NAMEs: HETRICK, WILLIAM P (contact)

PROJECT_TERMS: clinical translation;Public Health;Training;Translational Research

PROJECT_TITLE: Training in Clinical Translational Science: Maximizing the Public Health Impact


NIH_SPENDING_CATS: Aging

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: While the rapid increase of our elderly population has led to a burden of disease and disability that threatens our society, new research is identifying universal mechanisms that determine and even regulate the aging of all organisms and impact all organ systems. Our aim is to train the next generation of scientists to engage in interdisciplinary research aimed at discovering and implementing therapies that alleviate the suffering caused by age-associated degenerative processes. The collaboration of scientists from diverse backgrounds enhances creativity and innovation by bringing together a wide range of perspectives, and our goal is to provide rigorous training to our students and postdocs to become leaders in the broad area of aging biology, and to increase the diversity and quality of the national work force in this area.

PI_NAMEs: NERETTI, NICOLA ;SEDIVY, JOHN M (contact);TATAR, MARC

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Biology of Aging;Molecular Biology;Training Programs;Universities

PROJECT_TITLE: Brown University Training Program in the Molecular Biology of Aging


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The process of sex determination has significant consequences on animal development and results in distinct differences in organ systems, behavior, and even responses to diseases. Animals like humans and flies use conserved mechanisms, such as the Doublesex/Mab3 Related Transcription Factors (DMRTs) and steroid hormone signaling, to regulate sexual development in the gonad. Elucidating these mechanisms is critical for understanding how sexual development occurs and can further treatment of human syndromes leading to Differences of Sexual Development and infertility.

PI_NAMEs: GOETTING, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Adult;Affect;Animals;Antibody Formation;Appearance;Behavior;Binding;Bioinformatics;Biological Assay;Birds;Body System;Cell Differentiation process;cell type;Cells;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Confocal Microscopy;Data;Development;differential expression;Disease;Drosophila genus;Ecdysone;ecdysone receptor;Environmental Risk Factor;Exhibits;experimental study;Family;Female;Fishes;fly;gain of function;Genes;Genetic;Germ Cells;Goals;gonad development;Gonadal structure;hormonal signals;Human;Infertility;Knowledge;loss of function;male;Mammals;member;Molecular;molecular marker;Mus;mutant;Nature;Ovarian;Ovary;Phenotype;Physiologic pulse;Process;Processed Genes;programs;Property;protein protein interaction;Proteins;Rana;receptor expression;Repression;Reproductive Health;Research;response;RNA Interference;Role;sex;Sex Chromosomes;sex determination;Sex Differences;Sexual Development;sexual dimorphism;sexual identity;Signal Transduction;Somatic Cell;Stains;steroid hormone;Structure;Supporting Cell;Syndrome;Tertiary Protein Structure;Testis;transcription factor;Visualization;Work

PROJECT_TITLE: Determining how Doublesex and sex-specific steroid hormone signaling control gonad development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: While previous research primarily focused on the properties of the cancer cell, in recent years, there has been an increasing interest in understanding the role of the tumor stroma in supporting cancer growth. It has become clear that to develop effective strategies against pancreatic cancer, tumor stroma needs to be addressed. In this regard, our preliminary data suggest that NFκB signaling in pancreatic cancer stroma is pro-tumorigenic and promotes tumor growth by creating an immunosuppressive environment. In the current grant application, we will decipher how stromal NFκB modulates pancreatic cancer growth. Successful completion of these studies will lead to discovery of novel strategies to modulate tumor microenvironment for therapeutic purposes.

PI_NAMEs: DUDEJA, VIKAS  (contact)

PROJECT_TERMS: Address;Affect;anti-cancer;Antibodies;Applications Grants;Biological Assay;cancer cell;CD8B1 gene;Cell Death;Cell Physiology;checkpoint therapy;chemokine;Consensus;cytokine;Cytotoxic T-Lymphocytes;Data;Dependence;Desmoplastic;Development;Disease;Environment;Evaluation;Extracellular Matrix;Fibroblasts;General Population;Genetic Engineering;Genetically Engineered Mouse;Grant;Growth;Human;Immune;immune cell infiltrate;In Vitro;in vivo;Inflammation;Inflammatory;insight;interest;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;military veteran;mouse model;Mutation;Neoplasm Metastasis;novel;novel strategies;novel therapeutic intervention;Nude Mice;Outcome;overexpression;Pancreas;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;Pathway interactions;Patient-Focused Outcomes;Play;Property;RANTES;Records;Research;Role;Signal Transduction;Site;Specimen;statistics;success;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;The Cancer Genome Atlas;Therapeutic;Transcript;transcriptomics;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;tumorigenic;Veterans

PROJECT_TITLE: Impact of Inflammatory Pathway in Tumor Stroma on Pancreatic Cancer Growth


NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Protein-coding genes must generate functional RNAs at the appropriate levels, and this process is controlled by many different molecular machines, including the Integrator complex and the spliceosome. The proposed studies will characterize in detail how Integrator controls the amount of RNA that is produced as well as why abundant circular RNAs are generated from many protein-coding genes by the spliceosome. This will allow us to better understand how gene outputs are controlled, thereby providing important new insights into how gene misregulation can lead to disease.

PI_NAMEs: WILUSZ, JEREMY E (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Attenuated;Binding;Biochemical;Biogenesis;Cell Physiology;circular RNA;Code;Complex;Coupled;crosslink;Data;Disease;Endoribonucleases;gene function;Genes;Genome;genomic locus;high throughput screening;innovation;insight;Laboratories;Length;Link;Mass Spectrum Analysis;Messenger RNA;Modality;Molecular;Molecular Machines;novel;Output;paralogous gene;Pathway interactions;Physiological;Poly(A) Tail;posttranscriptional;premature;Process;Production;Proteins;recruit;RNA;RNA Polymerase II;RNA Processing;Role;Small Nuclear RNA;Spliceosomes;Tertiary Protein Structure;Therapeutic;Transcript;transcription termination;Untranslated RNA;Work

PROJECT_TITLE: Regulatory roles for the Integrator complex and circular RNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Services;Human Genome;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The discovery and clinical use of polygenic risk scores (PRS) for complex traits promises to dramatically change the practice of medicine. Our eMERGE IV grant will leverage a large Biobank and a rich electronic medical record to define the clinical impact of PRS derived from diverse populations and the clinical impact of returning these results along with family history and clinical risk information to participants and their healthcare providers.

PI_NAMEs: KARLSON, ELIZABETH W (contact);MURPHY, SHAWN N;SMOLLER, JORDAN W

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Algorithms;All of Us Research Program;Asian;Atrial Fibrillation;behavioral outcome;Benchmarking;biobank;Bioinformatics;Black race;Clinical;clinical care;clinical center;Clinical Data;clinical decision support;clinical implementation;clinical practice;clinical research site;clinical risk;Colorectal Cancer;Communication;Complex;Computerized Medical Record;Consent;Coronary Arteriosclerosis;Data;Data Set;design;Development;Disclosure;Disease;Disease Outcome;economic outcome;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;ethical, legal, and social implication;Ethnic Origin;evidence based guidelines;exome;experience;Family;Fast Healthcare Interoperability Resources;genetic analysis;Genetic Risk;genome resource;genome wide association study;Genomics;Genotype;Glycosylated hemoglobin A;Goals;Grant;Harm Reduction;health care service utilization;Health Personnel;Healthcare;high risk;high risk population;Hispanic;Individual;Information Technology;insight;Intervention;Japan;Laboratories;Leadership;Life Style;Link;Low-Density Lipoproteins;machine learning algorithm;Major Depressive Disorder;Medical;Medicine;Mental Depression;Methods;multi-ethnic;New England;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Outcome and Process Assessment;Participant;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phase;Phenotype;Physical activity;Physicians;polygenic risk score;Population Heterogeneity;portability;Predictive Value;Preventive;Preventive therapy;primary outcome;Process;programs;psychiatric genomics;Random Allocation;Recommendation;Recording of previous events;recruit;Reporting;Risk;Risk Assessment;Risk Factors;Risk Reduction Behavior;risk stratification;screening;Statistical Methods;support tools;Surveys;Testing;training data;trait;Trans-Omics for Precision Medicine;Veterans;Visit

PROJECT_TITLE: eMERGE Phase IV Clinical Center at Mass General Brigham


NIH_SPENDING_CATS: Cardiovascular

ORG_NAME: RHODE ISLAND HOSPITAL

PHR: Project Narrative Cardiovascular diseases are the major causes of morbidity and mortality in the United States. This Cardiovascular Surgery Research Training Program aims to prepare next-generation scientists and clinician- scientists in state-of-the-art cardiovascular research by training surgery residents and postdoctoral fellows through outstanding mentored research experiences. This Program will help advance basic and translational research to develop novel therapeutic modalities by a group of well-trained cardiovascular academic researchers.

PI_NAMEs: SELLKE, FRANK W (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiovascular Surgical Procedures;Research Training


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Babies experience dramatic changes in their metabolism after heart surgery that may lead to heart failure, organ damage, or even death. Currently little is known about the specific metabolism changes that are most dangerous or how to fix them. In our project we will use blood tests from our patients to better understand these metabolism changes and then test metabolism in important organs in an animal model of heart surgery.

PI_NAMEs: DAVIDSON, JESSE  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Animal Model;arm;Blood Tests;Cardiac Surgery procedures;Cardiopulmonary Bypass;cardiovascular collapse;Cardiovascular system;Cell Physiology;Cerebrum;Cessation of life;Child;Childhood;Clinical;Complex;Congenital Abnormality;congenital heart abnormality;cost;Dangerousness;Data;Development;enzyme pathway;Evolution;experience;Failure;Family;Genome;Goals;Healthcare Systems;Heart Arrest;Heart failure;high risk;Homeostasis;Hospital Costs;Hospitalization;Individual;Infant;Injury to Kidney;innovation;Intensive Care Units;Intervention;Kynurenine;Length of Stay;Life;Live Birth;Maintenance;Maps;Measures;mechanical circulatory support;Metabolic;Metabolic Pathway;metabolic profile;Metabolism;metabolome;metabolomics;mortality;natural hypothermia;new therapeutic target;Niacinamide;novel;novel diagnostics;Operative Surgical Procedures;Organ;organ injury;Outcome;palliation;Pathologic;Pathway interactions;Patients;Perfusion;perioperative mortality;Physiological;Physiology;porcine model;Postoperative Period;Production;Prospective, cohort study;Proteome;Renal Tissue;Respiratory Failure;response;Risk;Sex Differences;Single ventricle congenital heart disease;small molecule;Stress;surgical risk;Systems Biology;Techniques;Testing;Therapeutic;Tissues;translational approach;Tryptophan;Tryptophan 2,3 Dioxygenase

PROJECT_TITLE: Metabolic profiling and comprehensive metabolic pathway mapping: a systems biology approach to cardiovascular failure and organ injury following infant congenital heart disease surgery

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Myelination is essential for the transmission of electrical signals along axons in the central nervous system (CNS) and the mechanisms underlying its formation and plasticity are still not fully understood. This study aims to test the hypothesis that subunits of voltage-gated calcium channels positively control CNS myelin development and remyelination after trauma or disease. If successful, this study will further our understanding of the cellular and molecular mechanisms controlling myelination and provide molecular targets that can be manipulated for therapeutic gain to promote remyelination after CNS injury and disease.

PI_NAMEs: SUN, WENJING  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Action Potentials;Adult;Affinity;Anatomy;Axon;Behavior assessment;Behavioral;Binding;Biochemical;biophysical properties;Calcium Channel;cell behavior;Cell Differentiation process;Cell membrane;Cell Proliferation;Cells;Central Nervous System;Central Nervous System Diseases;central nervous system injury;Cervical;Coculture Techniques;conditional knockout;Data;Demyelinating Diseases;Demyelinations;design;Development;Disease;dorsal column;Electrophysiology (science);Ensure;Exhibits;experimental study;Failure;gabapentin;gain of function;Genes;genetic approach;Histologic;imaging approach;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;Injury;interdisciplinary approach;Knockout Mice;Length;loss of function;Lysophosphatidylcholines;Mammals;Mediating;Mediator;Modeling;Molecular;Molecular Target;Motor;Multiple Sclerosis;Mus;Myelin;Myelin Proteins;Myelin Sheath;myelination;nervous system development;Nervous System Physiology;neural network;Neurologic;Neurons;neurotransmission;neurotransmitter release;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;overexpression;Pathway interactions;Pattern;pharmacologic;precursor cell;presynaptic;Presynaptic Terminals;Process;Proliferating;promoter;Proteins;Publishing;Recovery of Function;remyelination;repaired;Role;Sensory;Series;Signal Transduction;spatiotemporal;Speed;Spinal Cord;Synapses;Synaptic Transmission;Synaptic Vesicles;Tamoxifen;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Thick;transcriptomics;Transgenic Mice;Translational Research;transmission process;Trauma;Traumatic CNS injury;Travel;vesicular release;viral gene delivery;voltage

PROJECT_TITLE: Novel molecular mediators for activity-dependent myelination


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Proliferative diabetic retinopathy (PDR) represents advanced diabetic eye disease and can result in permanent vision loss. The electronic health record (EHR) can be a powerful tool for studying real-world outcomes of conditions like PDR to help prevent disease occurrence and improve outcomes. We will develop and validate EHR-based methods and tools to improve outcomes in PDR, which can also be applied to other eye conditions to facilitate future EHR-based clinical studies in ophthalmology.

PI_NAMEs: SUN, CATHERINE QING (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;aged;Algorithms;Anatomy;Background Diabetic Retinopathy;biomedical informatics;Biometry;Blindness;California;Caring;Classification;Clinical;clinical data warehouse;Clinical effectiveness;Clinical Research;Clinical Trials Design;Code;comparison intervention;cost effectiveness;Data;Data Analytics;Data Set;Databases;design;Development;diabetic;Diabetic Retinopathy;Diagnosis;Disease;Effectiveness;Electronic Health Record;electronic health record system;Eligibility Determination;Environment;Ethnic Origin;Eye;Eye diseases;follow-up;Foundational Skills;Foundations;Funding;Future;future implementation;General Hospitals;Goals;health disparity;Health Insurance;Healthcare;high risk;Hospitals;ICD-9;Image;improved;improved outcome;Infrastructure;Injections;innovation;Intervention;Knowledge;Light Coagulation;low socioeconomic status;Manuals;Measures;medication compliance;Mentors;Mentorship;Methods;Modeling;Natural Language Processing;novel;Observational Study;ophthalmic examination;Ophthalmologist;Ophthalmology;Outcome;Outcome Study;Outpatients;Participant;Patient Recruitments;Patients;Performance;Pharmaceutical Preparations;Physicians' Offices;Pragmatic clinical trial;predictive modeling;prevent;primary outcome;proliferative diabetic retinopathy;Prospective Studies;Provider;Publishing;Race;Randomized, Controlled Trials;Registries;Reporting;Research;Research Personnel;Retina;Retrospective Studies;Risk Factors;risk stratification;routine care;San Francisco;Structure;structured data;Techniques;Testing;Text;Time;tool;Training;treatment as usual;Treatment Effectiveness;United States;Universities;unstructured data;Vascular Endothelial Growth Factors;Vision;Visual

PROJECT_TITLE: Real-world outcomes of proliferative diabetic retinopathy


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: The Boston University Rheumatology Research Training (BURRT) T32 Program will provide a comprehensive two-year multidisciplinary training program in rheumatic and musculoskeletal diseases for postdoctoral MD and PhD scholars to pursue academic and scientific clinical research careers. The program will train 3 postdoctoral scholars every 2 years in a core curriculum and several specialized tracks under the guidance of experienced and funded mentors, and supported by a broad curriculum with coursework, seminars, roundtables, team research meetings, and hands-on experiences. Ultimately, the program aims to have T32 scholars successfully transition to independent clinical research careers as the next general of leaders in rheumatic and musculoskeletal disease research.

PI_NAMEs: NEOGI, TUHINA  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Public Health Statement Alzheimer's disease (AD) is the leading cause of dementia and imposes tremendous burdens on families, communities, and the health care system. Tragically, the population of Americans suffering from AD is expected to grow to 16 million by 2050. There is no cure, but insights into the pathophysiology of AD promises more effective treatments to ease symptoms, slow progression, and prevent disease. This is an application for the training of pre-doctoral and post-doctoral fellows in the area of Alzheimer's Disease (AD) related to neurodegenerative disorders pathophysiology.

PI_NAMEs: KAYED, RAKEZ  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Alzheimer's Disease;Functional disorder;post-doctoral training;pre-doctoral

PROJECT_TITLE: Predoctoral and Postdoctoral Training in Alzheimer's Pathophysiology

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Basic Neuroscience of Aging Study Section[NIA-N]


NIH_SPENDING_CATS: Dystonia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative Fundamental features of the nervous system development and function are regulated by the extra cellular matrix (ECM), a complex three-dimensional milieu surrounding the cells. This proposal will study a newly described cellular pathway that has a critical role in brain development, motor function and regulating the composition of the brain ECM. This pathway is regulated by the protein THAP1, whose loss of function leads to the neurodevelopmental movement disorder, dystonia.

PI_NAMEs: DAUER, WILLIAM T.;YELLAJOSHYULA, DHANANJAY  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: 3-Dimensional;Adult;Astrocytes;autocrine;Automobile Driving;Brain;Cell Lineage;Cell Maturation;cell type;Cells;Childhood;ChIP-seq;chondroitin sulfate glycosaminoglycan;Chondroitin Sulfates;Complex;Cre driver;Data;Defect;defined contribution;Development;Dystonia;Dystonic Disorder;Enzymes;Extracellular Matrix;GAG Gene;Generations;Genes;Genetic;Genetic Transcription;Goals;Homeostasis;Human;Impairment;In Situ;In Vitro;in vivo;inducible Cre;loss of function;loss of function mutation;mature animal;Mediating;Metabolic Pathway;Metabolism;Molecular;Motor;motor disorder;motor learning;Motor Skills;Movement Disorders;Mutate;myelination;nervous system development;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;Neuronal Plasticity;Neurons;novel;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;paracrine;Pathogenesis;Pathway interactions;Play;Polysaccharides;Process;programs;Proteins;Publishing;Regulation;Research;Role;scaffold;Signal Transduction;skills;stem cells;Synaptic plasticity;Testing;transcription factor;Transcriptional Regulation;transcriptomics;Work;YY1 Transcription Factor

PROJECT_TITLE: Role of DYT6 Dystonia Protein THAP1 in Oligodendroglial Mediated ECM Homeostasis During CNS Development


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The Predoctoral Program in Cellular, Molecular and Quantitative Biology at Yale University will develop rigorously trained early-career scientists prepared to operate ethically as future leaders in biological and biomedical research-related careers.

PI_NAMEs: BASERGA, SUSAN J (contact);LUSK, CHARLES PATRICK

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biology;Molecular;pre-doctoral;programs

PROJECT_TITLE: Predoctoral Program in Cellular, Molecular and Quantitative Biology (CMQBTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Pediatric

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Project Narrative In this renewal application, we will investigate a novel tool of benefit-risk analysis for the presurgical evaluation of pediatric drug-resistant focal epilepsy which utilizes the state-of-the-art deep convolutional neural network (DCNN)-based tract classification to provide an optimal resection boundary of the epileptogenic area resulting in the maximized benefit (seizure freedom) and minimized risk (functional deficit including motor, language, hearing, and vision). We will also study if the integration of DCNN and DWI connectome helps decide timely surgery by providing preoperative imaging markers underlying a high likelihood of postoperative neurocognitive improvements and mechanistic insight in structural brain reorganization associated with postoperative verbal IQ improvement. The results of this project will translate deep learning-based diffusion MRI techniques to optimize the surgical margin, predict the postoperative neurocognitive outcome, and determine the specific mechanism of postoperative brain reorganization, which will be validated for optimizing clinical benefit-risk analysis before surgical intervention.

PI_NAMEs: JEONG, JEONG-WON  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Age;Area;Benefits and Risks;Biological Markers;Brain;brain tissue;Childhood;childhood epilepsy;Classification;Clinical;Clinical Management;cognitive regression;cohort;connectome;Contralateral;convolutional neural network;Crowding;Data;deep learning;Detection;Development;Diffusion Magnetic Resonance Imaging;Drug Evaluation;Drug resistance;Electric Stimulation;Epilepsy;Equilibrium;Evaluation;Excision;Family;Freedom;functional improvement;Funding;Goals;Hearing;Image;imaging biomarker;Imaging Device;improved;individual patient;insight;Language;language impairment;Left;Maps;Methods;Motor;Network-based;neural;Neurocognitive;non-verbal;novel;Operative Surgical Procedures;Outcome;Partial Epilepsies;Pathway interactions;Patients;Pharmaceutical Preparations;Postoperative Period;preservation;Probability;prospective;Protocols documentation;Provider;quantitative imaging;Risk;risk minimization;risk/benefit ratio;Sampling;Seizures;Severities;side effect;Speech;Structure;Surgical margins;Techniques;Therapeutic;tool;tractography;Translating;Treatment/Psychosocial Effects;United States National Institutes of Health;verbal;Vision;Visual;white matter

PROJECT_TITLE: Novel DWI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery.

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Pediatric

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Project Narrative Clinicians trained in the discipline of pediatric clinical pharmacology remain instrumental to the acquisition, adoption, and implementation of knowledge that guides the safe and effective use of medicines in children. Formal training in clinical pharmacology arms individuals with the skills necessary to 1) integrate the basic and clinical sciences, 2) design and analyze clinical trials, 3) characterize therapeutic outcomes and/or relevant surrogate biomarkers, and 4) define dose-exposure-response relationships. The program at Children’s Mercy, which accepted their first fellow in 1998, provides an exemplary environment in which to train the next generation of pediatric clinical pharmacologists and remedy the shortage of clinician scientists who have formal training in this discipline.

PI_NAMEs: RAMSEY, LAURA B;WAGNER, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TITLE: Children's Mercy Hospital Collaborative Fellowship Program in Pediatric Pharmacology


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Narrative Impaired mitochondrial calcium homeostasis has been linked to both common and rare neurological disorders. Recent evidence indicates that genetic loss of the gatekeepers of mitochondrial calcium uptake, MICU1/2, causes progressive neurological disease in both human and mouse but the underlying mechanism remains elusive. The proposed work will help to understand the dynamic and complex physiological involvements of the MICU proteins, and the neurological pathogenesis caused by their inherited as well as acquired acute loss.

PI_NAMEs: HAJNOCZKY, GYORGY  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 3-Dimensional;Acute;Adult;Affect;Animals;Antioxidants;Architecture;Area;behavior test;Behavioral;Biochemistry;Birth;Brain;Brain Hypoxia;Brain Injuries;Calcium;Calcium Signaling;calcium uniporter;Cell Death;cell injury;Cells;Chemicals;Complex;Corpus striatum structure;Cytoplasm;Data;Dendritic Spines;Dependence;Development;dimer;Disease;Down-Regulation;Electron Microscopy;Etiology;Exposure to;falls;Fibroblasts;Fluorescence;fluorescence imaging;Fluorescent Dyes;Functional Imaging;Gatekeeping;Genetic;Genetic Models;Glutathione Disulfide;Health;Health system;Hepatocyte;Hippocampus;Homeostasis;Human;Hydrogen Peroxide;Hypoxia;Image;Impaired cognition;Impairment;in vivo;Inherited;inhibitor;Injury;Ischemia;Knockout Mice;Learning;Life;Link;loss of function;Mammals;Measures;Mediating;Membrane;Microscopy;Mitochondria;Molecular;Morphology;Motor;Motor Cortex;motor disorder;motor impairment;mouse model;multi-photon;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;Nervous System Physiology;Neuroanatomy;Neurologic;Neuronal Injury;Neurons;neuropathology;Neurosecretion;new therapeutic target;Outcome;Outer Mitochondrial Membrane;Oxidants;paralogous gene;Pathogenesis;Pathogenicity;Patients;Peptide Hydrolases;Permeability;Phenotype;Physiological;Physiology;Positioning Attribute;Presynaptic Terminals;prevent;Process;Production;protective effect;Protein Isoforms;Proteins;recruit;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporter;Reporting;Resolution;Role;scaffold;sensor;Shapes;Signal Transduction;Spinal Cord;Stains;Stress;Stroke;Structure;Synapses;Synaptic Vesicles;targeted treatment;Testing;ultra high resolution;uptake;vesicular release;Work

PROJECT_TITLE: Mitochondrial Calcium and Neuronal Health

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: PROJECT NARRATIVE Trauma is a leading cause of death worldwide. A large proportion of trauma-related deaths that occur in the days to weeks following injury are caused by multi-organ failure that is driven by loss of microvascular barrier function. The proposed studies will support innovative programmatic areas of research to advance our understanding of the pathophysiologic mechanisms of trauma-induced endothelial damage that will guide the identification of novel therapeutic targets after injury.

PI_NAMEs: RICHTER, JILLIAN ROUSE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Area;Attenuated;Basic Science;Blood Vessels;Body System;Cause of Death;Cell surface;Cessation of life;Endothelial Cells;Endothelium;Functional disorder;Glycocalyx;Glycosaminoglycans;Goals;Hemorrhage;Hemorrhagic Shock;heparanase;Heparitin Sulfate;Hyaluronic Acid;Inflammation;Injury;innovation;Intestines;Kidney;Lung;Mediating;Microvascular Dysfunction;Microvascular Permeability;mortality;Multiple Organ Failure;new therapeutic target;Organ;organ injury;Patients;Permeability;Predisposition;prevent;programs;repaired;Research;response;Resuscitation;Role;Secondary to;Signal Pathway;translational research program;translational study;Trauma;Traumatic injury

PROJECT_TITLE: Endothelial Glycocalyx Disintegrity: Repairing the Damage caused by Trauma-Hemorrhage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The overall aim of Dr. Jae Sevelius' K24 application is to develop and implement intersectional approaches to mentoring and patient-oriented research focused on HIV prevention and treatment interventions with transgender and gender diverse people who use substances. The specific aims of the research strategy are as follows: (1) to characterize the relationships between experiences of transgender-related discrimination, substance use, and engagement in HIV care among transgender women living with HIV, (2) to assess how implementation of an existing intervention for transgender women living with HIV is impacted by substance use among participants, and (3) to develop a contextually grounded understanding of multi-level intersectional stigma, including substance use stigma, among transgender women in Brazil to inform measurement refinement and future intervention strategies. Dr. Sevelius' specific focus on developing an intersectional approach to mentoring in patient-oriented research on substance use and HIV has the potential to directly contribute to increasing the pipeline of diverse researchers entering the field who have the capacity to develop and advance innovative approaches to major challenges in HIV prevention and substance use research.

PI_NAMEs: SEVELIUS, JAE M. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Address;Adherence;AIDS prevention;Alcohols;Area;Behavior;Behavioral;Brazil;California;career;career development;Caring;Categories;Clinical Investigator;cohort;Collaborations;Communities;community organizations;Data;Data Analyses;Dedications;design;Development Plans;Discrimination;Economics;efficacy testing;Enrollment;Evaluation;experience;Focus Groups;Funding;Future;Gender;gender affirmation;gender diverse;Health;Health behavior;health disparity;Health Personnel;Health Promotion;Healthcare;HIV;HIV disparities;HIV prevention trial;HIV risk;implementation evaluation;implementation science;implementation study;improved;Individual;Inequality;informant;Infrastructure;innovation;insight;Institution;International;intersectionality;Intervention;Intervention Studies;Interview;Investigation;Knowledge;Link;marginalization;Measurement;Medicine;Mentors;Mentorship;mid-career faculty;Modeling;multidisciplinary;novel;Outcome;Participant;patient oriented research;Pattern;Persons;Pharmaceutical Preparations;Policy Maker;Population;preventive intervention;programs;Property;protective factors;Race;Randomized, Controlled Trials;Research;Research Activity;Research Personnel;Research Proposals;research study;Research Support;residence;Resources;Risk;Risk Factors;San Francisco;Scholarship;secondary analysis;sex;Sex Orientation;Sexual and Gender Minorities;skills;social;Social Environment;Social Identification;Social Processes;Social status;social stigma;substance use;Testing;theories;Training;training opportunity;transgender;transgender women;transmission process;United States;Universities;Unsafe Sex;Woman;Work;Writing

PROJECT_TITLE: Mentoring clinical investigators in patient-oriented research on substance use and HIV

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Dissemination and Implementation Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE To address the widely recognized decline in the physician-scientist workforce, we propose to establish the University of Southern California Stimulating Access to Research in Residency (USC-StARR) Program to foster the development of surgeon-scientists in the field of cardiovascular and pulmonary disease. We have designed an intensive, 24-month, contiguous StARR program for select clinical residents in the General Surgery, Integrated Vascular Surgery, and Integrated Cardiothoracic Surgery Residency Programs. Through the development of an Independent Career Development Plan (ICDP), composed of research, education, and mentorship components, we will establish a program that will lead to both clinical and research competency and increase the ability of these surgeon-scientists to transition to other forms of research and career development support.

PI_NAMEs: HONG, YOUNG-KWON ;ITO, FUMITO  (contact);PATEL, SANJEET

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Basic Science;Blood Vessels;California;Cardiovascular Diseases;Cardiovascular system;career;career development;Clinical;clinical investigation;Clinical Research;clinically relevant;community engagement;Competence;Coupled;Credentialing;Dedications;design;Development;Development Plans;Dissemination and Implementation;dissemination research;diversity and inclusion;Education;Educational Status;epidemiology study;Evaluation;Fostering;Funding;Future;Goals;graduate medical education;Health;implementation research;Individual;Influentials;innovation;interest;Leadership;Lung;Lung Diseases;Medical;Mentors;Mentorship;Methodology;Mission;National Heart, Lung, and Blood Institute;novel strategies;Operative Surgical Procedures;Outcome;Philosophy;Physicians;population based;programs;Records;recruit;Research;research and development;Research Personnel;Research Project Grants;Research Support;Residencies;Science;Scientist;Senior Scientist;skills;Structure;Surgeon;Talents;Training;Training Programs;Translating;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: USC Stimulating Access to Research in Residency (USC-StARR) Program


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Epilepsy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE The goal of this project is to develop and validate a novel technology for noninvasive localization and imaging of the epileptogenic brain in drug resistant focal epilepsy patients. The successful development of the proposed technology promises to significantly improve the clinical management of drug resistive epilepsy, which is currently limited, benefiting numerous patients and the healthcare system.

PI_NAMEs: HE, BIN  (contact)

PROJECT_TERMS: Affect;American;Biological Markers;biophysical properties;Biophysics;Brain;Brain imaging;Brain region;Chronic;Clinical;Clinical Management;clinical practice;Computer Simulation;Computer software;computerized tools;Data;deep neural network;density;Development;Drug resistance;Electrodes;Electroencephalography;Electrophysiology (science);Epilepsy;epileptiform;Formulation;Goals;Healthcare Systems;Image;imaging approach;imaging capabilities;Imaging technology;implantation;Implanted Electrodes;improved;infection risk;innovation;Intractable Epilepsy;Machine Learning;Magnetoencephalography;Modeling;Monitor;neural;neural network;Neural Network Simulation;new technology;Non-linear Models;Nonpharmacologic Therapy;novel;open source;Operative Surgical Procedures;Outcome;Partial Epilepsies;Patients;Performance;Persons;Pharmaceutical Preparations;Procedures;Research;Scalp structure;Seizures;Source;spatiotemporal;surgery outcome;synthetic data;Techniques;technological innovation;Technology;Time;Tissues;tool;Training;training data

PROJECT_TITLE: Imaging Epilepsy Sources with Biophysically Constrained Deep Neural Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(91)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_NAME: TOGETHER SENIOR HEALTH, INC.

PHR: The primary goals of this Small Business Innovation Research (SBIR) Direct Phase II project are to test, refine, and bring to market a novel algorithm that uses electronic health data (including electronic health records [EHR] and insurance claims) to improve detection and diagnosis of Alzheimer’s disease and related dementia (ADRD). More than half of the 6.5 million Americans currently living with ADRD are undiagnosed. Lack of a diagnosis can result in delayed access to treatment, poor care management, unnecessary hospitalizations and emergency department (ED) visits, difficulty managing other chronic conditions, inability to participate in planning for future care, risky behaviors such as driving, and delayed access to caregiver support. Studies also have shown that healthcare costs for people with ADRD are three times higher than those without ADRD. For this reason, health plans are reimbursed by Medicare at a higher rate for patients diagnosed with ADRD. Multiple principal investigator (PI) Dr. Deborah Barnes and colleagues have developed and validated a novel algorithm called eRADAR (electronic health record [EHR] Risk of Alzheimer’s and Dementia Assessment Rule) that uses EHR data to identify patients at risk of having undiagnosed dementia with high accuracy. They have externally validated eRADAR in two healthcare systems, including confirming that the algorithm works well over time and in different race and ethnic groups. A limitation of eRADAR, however, is that it was designed as a static tool, and it does not learn from or adapt to new data streams. Many organizations that are interested in improving dementia detection, such as Medicare Advantage plans, have access to insurance claims data rather than EHR data. As part of Phase I proof-of-concept work for this grant, we created RADAR (Risk of Alzheimer’s and Dementia AlgoRithm), which uses Medicare claims data rather than EHR data to calculate a risk score for undiagnosed dementia that is similar to eRADAR. The primary goals of this SBIR Direct Phase II are to: 1) Retrospectively assess the accuracy of RADAR to detect undiagnosed dementia using historical Medicare claims data; 2) Develop an adaptive process using machine learning techniques to identify optimal RADAR predictor sets based on data inputs; and 3) Determine the optimal strategy for sharing RADAR’s output with clients interested in improving dementia detection and diagnosis. Together Senior Health’s mission is to serve people living with memory loss, cognitive decline and ADRD by providing evidence-based, online programming. Our current products include Moving TogetherTM–a mind-body group movement program for people with mild ADRD and care partners—and Brain Health Together, which combines Moving Together with brain health coaching to address modifiable risk factors. Our current clients include Medicare Advantage plans, home health agencies, and ADRD care centers. Adding RADAR to our product line will enable us to better support our business clients while also expanding access to our services and improving quality of life for people living with ADRD and those who care for them.

PI_NAMEs: BARNES, DEBORAH E.;BENJAMIN, CYNTHIA LOUISE (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: absorption;Address;Algorithms;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Appointment;Area Under Curve;Automobile Driving;brain health;Businesses;care costs;Caregiver support;Caring;Chronic;Client;cohort;commercialization;comorbidity;cost;Data;Data Set;Data Sources;data streams;Dementia;dementia care;dementia risk;design;Detection;Diagnosis;Disease;Early identification;eHealth;electronic health data;Electronic Health Record;Emergency department visit;Ethnic Population;evidence base;Face;flexibility;follow-up;Future;Goals;Grant;Health;Health Care Costs;Health Insurance;health plan;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;Home Health Agency;Hospitalization;human centered design;Impaired cognition;improved;insurance claims;interest;Learning;Machine Learning;Managed Care;Marketing;Medicare;Medicare claim;member;Memory Loss;Methods;mind/body;Mission;Modeling;modifiable risk;Movement;novel;Output;Patient Care;Patient risk;patient stratification;Patients;Persons;Phase;prediction algorithm;Predictive Value;Preparation;primary care patient;Principal Investigator;Process;prognostic algorithm;programs;prototype;Provider;Publishing;Quality of Care;Quality of life;racial population;Research Technics;response;Risk;Risk Behaviors;Risk Factors;risk sharing;risk stratification;Sampling;Services;Small Business Innovation Research Grant;Specificity;Techniques;Testing;Time;tool;Update;Work

PROJECT_TITLE: A Novel Algorithm to Identify People with Undiagnosed Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(10)B]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: Temperatures are rising due to climate change and, in parallel, psychopathology among U.S. adolescents has risen in the past decade; these concerns require a robust and innovative public health response. The role of the natural and built environments in affecting psychopathology remains largely unstudied, and this project aims to create high-resolution estimates of annual neighborhood surface temperatures, tree canopy cover, and other built environment sources of shade and green space to evaluate how these features impact psychopathology across time among adolescents. We will estimate typologies of neighborhood risk that can be utilized by public health and policy stakeholders to identify high-risk neighborhoods for which place-based interventions may be of the greatest public health relevance.

PI_NAMEs: KEYES, KATHERINE M. (contact);RUNDLE, ANDREW G

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Adolescent;Adverse effects;Affect;Air;Area;Biological;built environment;Cities;City Planning;climate change;climate-related health;cohort;Cohort Studies;Collaborations;Communities;County;Coupled;Crime;Data;Decision Making;design;Diagnostic;Dimensions;Economic Conditions;Economics;Environment;Environmental Epidemiology;experience;follow-up;Future;Genetic Code;Geography;Green space;Health;Health Policy;Health Promotion;high risk;High School Student;High temperature of physical object;Home;Human;improved;Incidence;Income;Inequity;Infrastructure;innovation;Intervention;Intervention Studies;Investigation;Investments;land use;life span;Link;Location;Los Angeles;Measurement;Measures;Mediating;Mental Health;metropolitan;Modeling;Modernization;mortality;Natural Source;Nature;Neighborhoods;neurobiological mechanism;ninth grade;novel;Outcome;Participant;Pathology;Personal Satisfaction;Physical environment;Plants;Policies;policy implication;Policy Maker;Politics;Population;population based;population health;protective factors;Psychiatric epidemiology;Psychopathology;Public Health;public health intervention;public health relevance;Public Policy;Race;Recording of previous events;recruit;remote sensing;Research;resilience;Resolution;response;Risk;Risk Factors;Role;Schools;Science;Shapes;social;Social Environment;social epidemiology;socioeconomic disparity;Socioeconomic Status;socioeconomics;Source;spatial epidemiology;Surface;Symptoms;Techniques;Temperature;Testing;Time;trait;Translating;Trees;trend;twelfth grade;Typology;urban area;urban planning;Variant;Work

PROJECT_TITLE: Temperature, shade, and adolescent psychopathology: understanding how place shapes health

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


PHR: Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to mitochondrial deficits and early onset PD. In this study, we will determine if dopaminergic neuronal growth and repair are dependent on changes to mitochondria that improve ATP synthase efficiency and rate of protein synthesis.

PI_NAMEs: JONAS, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Aging;Animals;ascorbate;ATP Synthesis Pathway;Axon;Behavior;Binding;Biogenesis;Biological Assay;Cells;Complex;Corpus striatum structure;Coupling;Crista ampullaris;Cues;Distal;Dominant-Negative Mutation;Dopamine;Dopaminergic Cell;dopaminergic neuron;early onset;Fibroblasts;Fluorescent in Situ Hybridization;Growth;Growth Factor;improved;in vivo;induced pluripotent stem cell;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Label;Length;Ligation;Link;Measures;Membrane;Messenger RNA;Metabolic;Mitochondria;Morphology;motor behavior;motor disorder;Movement;mRNA Translation;Mus;mutant;Mutation;Neuronal Dysfunction;neuronal growth;neuronal metabolism;Neurons;neurotransmission;Outer Mitochondrial Membrane;overexpression;Oxidative Phosphorylation;PARK7 gene;Parkinson Disease;Patients;Peroxidases;preservation;prevent;Prevention;Process;Production;protein activation;Protein Biosynthesis;Protein Deficiency;Protein Subunits;Proteins;Readiness;repaired;Reporting;response;Ribosomes;RNA;Role;Site;stoichiometry;Techniques;therapy development;Viral

PROJECT_TITLE: Role of DJ1 in mitochondrial biogenergetics and neuronal metabolism


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: Narrative Myopia, also known as nearsightedness, is a common visual impairment that can lead to serious diseases that cause permanent vision loss in some cases. The proposed project uses novel optical and psychophysical approaches to evaluate the optical and neural characteristics in the human peripheral visual system, revealing mechanisms underlying myopia development.

PI_NAMEs: YOON, GEUNYOUNG  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: adaptive optics;Affect;Age of Onset;Anisotropy;Astigmatism;Blindness;Bypass;Characteristics;Child;Clinic;Coma;Contact Lenses;Contrast Sensitivity;Data;design;Development;Disease;effective intervention;Environment;experimental study;Exposure to;Eye;Eye diseases;Genetic;Goals;Human;Hyperopia;Image;improved;Individual;innovation;insight;Intervention;Investigation;lens;Life;Link;Long-Term Effects;Longitudinal Studies;Measurement;Measures;Methods;Myopia;neural;Neurophysiology - biologic function;novel;Optics;Peripheral;Play;Population;portability;Prevalence;prevent;Process;Psychophysics;Radial;Refractive Errors;response;Retina;retinal imaging;Risk Factors;Role;sample fixation;Scanning;Schools;sensor;Shapes;Space Perception;success;Testing;Thick;Time;tool;Validation;Vision;Visual;Visual impairment;Visual System

PROJECT_TITLE: Peripheral optical and neural contributions to myopia development


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: The future of biomedical research in the U.S. will depend on the rigorous training of PhD scientists who can think critically and independently, and who use cutting edge Molecular Biophysical approaches to solve important biomedical problems. The Molecular Biophysics Training Program at the University of California, San Diego fosters the development of dedicated Molecular Biophysics researchers who can apply rigorous research approaches across disciplinary boundaries, choose research problems with important human health implications, and communicate their results effectively. The Program serves as the campus “home” for Molecular Biophysics, and provides rigorous training, high-quality individual mentorship, and career guidance for graduate students from different graduate programs pursuing research projects in the area of Molecular Biophysics.

PI_NAMEs: KOMIVES, ELIZABETH A. (contact);ZHANG, JIN

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Biophysics;Grant;Molecular;Training

PROJECT_TITLE: Molecular Biophysics Training Grant at UC San Diego


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Sleep Research;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE We know that rural residents in the Appalachian region of the Southeastern United States have the nation’s highest rates of insufficient sleep (habitual sleep duration ≤6 hours), but the reasons for this are unclear. This issue is particularly concerning, as these same rural residents also face substantially higher than average rates of negative health outcomes including heart disease, cancer, diabetes, obesity, depression, and substance use disorders. We will follow a group of Appalachian adults over the course of two years to track their sleep, physical and mental well-being, and health behavior (e.g., substance use, smoking, diet, exercise), in order to better understand the culturally relevant factors that predict difficulties with both sleep and health in this unique and underserved, rural population.

PI_NAMEs: MOGA, DANIELA CLAUDIA;MOLONEY, MAIREAD  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Adult;Age;Alcohols;Anxiety;Appalachian Region;Attitude;Automobile Driving;Behavioral;Belief;Biological;Birds;C-reactive protein;Cardiovascular Diseases;Cardiovascular system;Caring;Child Sexual Abuse;Cirrhosis;Cognitive;cognitive task;cohort;Communities;cost;County;Data Collection;Demographic Factors;demographics;design;Diabetes Mellitus;Diet;Disease;Disparity;Distress;economic impact;Economics;Emotional;Equity;ethnic minority;Ethnic Origin;Exercise;Eye;Face;Family;Financial Hardship;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Health;Health behavior;health determinants;Health Disparities Research;health disparity;health disparity populations;health inequalities;Health Status Indicators;Heart Diseases;Heart Rate;holistic approach;Hour;Immunologics;Individual;Individual Differences;innovation;insight;interest;Interview;Kentucky;Knowledge;Lead;Link;longitudinal design;low socioeconomic status;Malignant Neoplasms;Measurement;Measures;Mediating;Memory;Mental Depression;Mental disorders;Metabolic;Methods;Modeling;Morbidity - disease rate;mortality;Neurocognitive Deficit;Obesity;Outcome;Overdose;Participant;Perception;Physical activity;Predictive Factor;Premature Mortality;Process;Productivity;protective factors;Public Health;Race;racial minority;Recording of previous events;recruit;Reporting;Research;Risk;Rural;Rural Appalachia;Rural Community;rural dwellers;rural health disparities;Rural Population;rurality;Scientific Advances and Accomplishments;self reliance;Series;sex;Sex Differences;Sleep;Sleep Deprivation;sleep health;Smoking;social;social determinants;social factors;Social support;Societal Factors;Southeastern United States;Stress;Substance abuse problem;substance use;Substance Use Disorder;Suicide;Surveys;System;Task Performances;Testing;Time;Trauma;United States;United States National Institutes of Health;Violence;Well in self;Work

PROJECT_TITLE: Researching Equitable Sleep Time (REST) in Appalachia

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: SALT LAKE CITY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The University of Utah has over a four-decade long history of training exceptional biomedical informatics students who go on to have a profound and lasting impact on health discovery and delivery. This current application describes our adaption to the evolving scientific milieu, with a strong and integrated curriculum, a proactive diversity-centric recruitment strategy, an unparalleled research environment for trainees, and a collaborative and energetic mentor pool. The program is supported by robust evaluation procedures that enable growth and continuous learning.

PI_NAMEs: EILBECK, KAREN LOUISE (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Area;Bioinformatics;biomedical informatics;career;Clinic;Clinical Informatics;Clinical Research;Creativeness;Dedications;Development;Education;Educational Curriculum;Ensure;Environment;Evolution;Exercise;Faculty;Foundations;Funding;Grant;Health;health practice;Health Sciences;Healthcare;Industry;Informatics;informatics training;innovation;Instruction;International;knowledge base;learning strategy;Medical center;Mentors;Methodology;Mission;next generation;Postdoctoral Fellow;Productivity;Program Evaluation;programs;Public Health Informatics;recruit;Reproducibility;Research;Research Methodology;Resources;responsible research conduct;Science;skills;Solid;Students;theories;Training Programs;Underrepresented Minority;underserved community;United States Department of Veterans Affairs;United States National Library of Medicine;Universities;Utah;Woman

PROJECT_TITLE: University of Utah Biomedical Informatics Training Grant


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Rectal cancer patients have significantly improved quality of life when surgery can be avoided. Carbon monoxide, which has been shown to have beneficial properties at low concentrations with roles in modulation of diverse physiological and pathological processes such as inflammation and cancer, may improve anti-tumor response to chemoradiotherapy and paradoxically protect surrounding normal rectum. To improve neoadjuvant therapy and reduce the likelihood of requiring surgery, I propose the evaluation of novel CO biofoams as an adjunctive strategy to chemoradiotherapy and will evaluate the mechanism of protection in tumors and normal tissue.

PI_NAMEs: BYRNE, JAMES DONALD (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acute;Adjuvant Therapy;anti-cancer;antioxidant enzyme;Antioxidants;antitumor effect;Antitumor Response;Biochemical;Biocompatible Materials;biological adaptation to stress;Biology;biomaterial development;Cancer Biology;cancer cell;Cancer Patient;Carbon Monoxide;Catabolism;cell killing;Cell Respiration;Cell Survival;Cells;Cellular biology;chemoradiation;Chronic;Colorectal Cancer;Combination Drug Therapy;Cytoprotection;Diagnosis;Dose;Doxycycline;Environment;enzyme pathway;Epithelial Cells;Evaluation;Excision;Exposure to;Formulation;Free Radicals;gastrointestinal;Gastrointestinal tract structure;Genes;Genetic;Goals;Heme;heme oxygenase-1;Hydrogen Peroxide;improved;improved outcome;In Vitro;in vivo;Incidence;Individual;Inflammation;Inhalation;International;intestinal epithelium;Intestines;Iowa;Knockout Mice;Lead;Malignant Neoplasms;Mentors;Metabolic;Methodology;Methods;mimetics;Mitochondria;Modeling;Molecular;Molecular Biology;mouse model;Mus;Neoadjuvant Therapy;neoplastic cell;Normal Cell;Normal tissue morphology;novel;novel therapeutics;Operative Surgical Procedures;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathologic Processes;Pathway interactions;pharmacologic;Physicians;Physiological Processes;Positioning Attribute;preservation;Proctitis;Production;Property;Quality of life;Quantitative Evaluations;Radiation;radiation response;Radiation Tolerance;Radiosensitization;Rectal Cancer;Rectum;Regimen;Research;response;Role;Scientist;Severity of illness;Signal Transduction;skills;Stress;Superoxides;Testing;Therapeutic;tissue injury;Tissues;tool;Training;transcription factor;Translating;translational therapeutics;Translations;Tumor Burden;Tumor Tissue;United States;Universities;Work

PROJECT_TITLE: Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal Bowel

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Precision Medicine;Prevention;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to identify protein biomarkers for cardiovascular disease (CVD) in patients with rheumatoid arthritis (RA), leveraging the structure of a randomized controlled trial and rigorous methods for deriving and validating a risk score. The aims will translate clinical and basic science to impact the care of patients with RA and to further explain the relationship between RA and CVD through proteomics, transcriptomics, and cellular immunology.

PI_NAMEs: SOLOMON, DANIEL HAL (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Aftercare;arthritis registry;Atherosclerosis;Basic Science;biobank;Biological Markers;biomarker discovery;biomarker panel;biomarker selection;biomarker validation;Blood Coagulation Factor;Blood Vessels;Calibration;Cardiovascular Diseases;cardiovascular disorder risk;cell type;Cells;Cellular Immunology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Clinical;Clinical Sciences;cohort;Cohort Studies;Complement;Cross-Sectional Studies;cytokine;Data;Data Set;Discrimination;Disease;Epidemiology;Equation;Event;experience;fluorodeoxyglucose positron emission tomography;Funding;Gene Expression;General Population;Goals;high dimensionality;Image;Immune;improved;Individual;Inflammation;Inflammatory;insight;life span;Ligands;Link;Lipids;Literature;longitudinal analysis;Measurable;Measures;Methods;Modeling;Morbidity - disease rate;Myocardial Infarction;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Outcome;Pathway interactions;Patient Care;patient subsets;Patients;Performance;Peripheral Blood Mononuclear Cell;PET/CT scan;Phenotype;Population;programs;prospective;protein biomarkers;Proteins;Proteomics;randomized, clinical trials;Randomized, Controlled Trials;receptor;Reporting;Research Personnel;responders and non-responders;Rheumatoid Arthritis;Risk;risk prediction;risk stratification;Running;Sampling;single-cell RNA sequencing;Source;Stroke;Structure;Surface;Testing;tool;transcriptomics;Translating;treatment arm;United States National Institutes of Health;uptake;vascular inflammation;Visit

PROJECT_TITLE: Rheumatoid Arthritis and the Risk of Cardiovascular Disease: Biomarkers Risk Prediction and Underlying Mechanisms

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]