ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PHR: PROJECT NARRATIVE Allosteric regulation of enzymes, which underpins many metabolic processes, can be perturbed by genetic mutations, contributing to metabolic re-programming in cancer and other diseases. The broadly evolutionarily conserved enzyme phosphofructokinase-1 (PFK-1) is allosterically regulated by many small molecules to control glycolytic flux in the cell, but the evolution and molecular mechanism of this regulation is poorly understood. We propose to characterize the complex combinatorial allosteric mechanism of PFK-1 towards the rational design of powerful therapeutics to target this essential enzyme in metabolic diseases and cancer.

PI_NAMEs: SUNDBERG, BELEN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: 6-Phosphofructokinase;Active Sites;Adenosine Diphosphate;Adenosine Triphosphate;Allosteric Regulation;Binding;Binding Sites;Biochemical;Biochemistry;Bioinformatics;Biological Process;biophysical techniques;Biophysics;Blood Platelets;C-terminal;cancer type;Cells;Citrates;combinatorial;Complex;Cyclic Peptides;Data;design;Deuterium;dimer;Dimerization;Disease;disease phenotype;Distal;DNA Sequence Alteration;Enzymes;Equilibrium;Escherichia coli;Escherichia coli drug resistance;Eukaryota;Evolution;Future;Gene Duplication;Genetic Drift;Glycolysis;Human;Hydrogen;Infection;inhibitor;insight;interdisciplinary approach;kinase inhibitor;Lead;Length;Ligands;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Metabolic;Metabolic Diseases;Metabolism;Methods;Molecular;Molecular Conformation;molecular dynamics;Multi-Drug Resistance;multidisciplinary;Multidrug Resistance Inhibition process;Mutate;Mutation;Orthologous Gene;Peptide Antibiotics;Peptides;phenomenological models;Phosphoenolpyruvate;Phosphotransferases;Population;Positioning Attribute;Post-Translational Protein Processing;predictive modeling;Process;Prokaryotic Cells;Protein Conformation;Protein Engineering;protein function;Proteins;rational design;Regulation;Role;Signal Transduction;Site;small molecule;Somatic Mutation;Specificity;Structure;Tail;Techniques;Testing;Therapeutic;therapeutic target;Toxic effect;Training;transmission process;Work

PROJECT_TITLE: Elucidating the complex allosteric regulation of PFK-1, a broadly evolutionarily conserved glycolytic enzyme

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Mental Health;Neurosciences;Pediatric;Social Determinants of Health;Violence Research

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Child maltreatment is a prevalent and costly public health issue associated with many negative outcomes, though the pathway through which these negative outcomes occur is not well understood. This application will examine the effects of child maltreatment on brain development as a potential pathway to negative outcomes. Results will guide future intervention and treatment efforts for individuals with a history of child maltreatment.

PI_NAMEs: CORSO, CASEY BURTON (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adolescent;adolescent health;adolescent mental health;Adult;adverse outcome;Affect;Age;Alcohol abuse;Anxiety;Area;Attention;Behavior;Brain;Brain imaging;Brain region;career;Child;Child Abuse and Neglect;Child Health;Cognition;Cognitive;cognitive development;cognitive neuroscience;Complex;Control Groups;cost;Data;Data Analyses;density;design;Development;Diabetes Mellitus;diagnostic strategy;Dimensions;Drug abuse;Economic Burden;emotional abuse;Etiology;Exhibits;experience;Exposure to;follow-up;Funding;Future;global health;Goals;gray matter;Health Care Costs;Heart Diseases;Heterogeneity;Hippocampus;improved;Incidence;Individual;innovation;Interdisciplinary Study;Interpersonal Violence;Intervention;Investigation;Knowledge;life span;Linear Models;Link;longitudinal dataset;Maps;Mediating;Mental Depression;Mental disorders;Mental Health;Morphology;National Institute of Child Health and Human Development;National Institute of Mental Health;neglect;Neurobiology;Neurocognitive;Outcome;Pathway interactions;Pattern;physical abuse;Prevention strategy;Process;psychologic;Psychopathology;Public Health;Recording of previous events;Research;Research Personnel;Research Support;Risk;Risk Factors;Role;Sampling;Scientist;sex;Sexual abuse;sexual risk taking;Site;skills;Strategic Planning;Stress;Structure;substance use;Surface;Time;transition to adulthood;Trauma;treatment strategy;United States;Work;Youth

PROJECT_TITLE: Neurodevelopmental Trajectories as an Explanatory Mechanism for Adverse Mental Health Outcomes following Child Maltreatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Natural Products;Nutrition

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Ulcerative colitis (UC), a chronic disease that is characterized by diffuse inflammation of the colonic and rectal mucosa, is rising globally. Current medications for UC include antibiotics, corticosteroids, and biological drugs, which can have deleterious off-target effects, contributing to increased susceptibility to severe infections and chronic immunosuppression. Building from our recent work documenting that dietary panaxynol, a bioactive component of American Ginseng, can mitigate colitis, I am proposing to examine immune, microbial and metabolite signatures to establish the potential mechanisms mediating panaxynol’s benefits in colitis.

PI_NAMEs: BULLARD, BROOKE  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Ablation;Adrenal Cortex Hormones;American;Anaerobic Bacteria;Animal Model;Antibiotics;Autoimmune;Bacteria;Bacteroidetes;Biological;Biological Assay;Body Weight decreased;Cells;Chronic;Chronic Disease;Clinical;Colitis;Colon Carcinoma;Colonic inflammation;Country;Data;Development;Diarrhea;dietary;Dietary Factors;Diffuse;Disease;Disparity;Dose;Environment;experience;Feces;Female;Firmicutes;Flow Cytometry;Fractionation;Genetic;Ginseng Preparation;Gnotobiotic;Goblet Cells;Grant;gut health;gut inflammation;gut microbes;gut microbiome;gut microbiota;Herb;Immune;Immune response;Immune system;Immune Targeting;Immunosuppression;Impairment;improved;indexing;Infection;Inflammation;Inflammatory Bowel Diseases;insight;intestinal barrier;Intestines;Large Intestine;male;Mediating;Mediator;Mentors;metabolic profile;metabolomics;microbial;microbiome;microbiota;microbiota profiles;Modeling;Mucosal Immunity;Mucous body substance;Mucous Membrane;multiple omics;murine colitis;Mus;Natural Products;North America;Outcome;Pathogenesis;Patients;Pharmaceutical Preparations;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Predisposition;Proctitis;Publishing;Quality of life;Recording of previous events;Regulatory T-Lymphocyte;Reporting;Research;resilience;Resources;response;Severity of illness;side effect;Source;Symptoms;Techniques;Testing;Training;trend;Ulcerative Colitis;Work

PROJECT_TITLE: Benefits of panaxynol on gut resilience in colitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed studies will elucidate the molecular mechanisms behind the development of varicose veins by leveraging the recent advances in single-cell sequencing technologies and induced pluripotent stem cells (iPSCs). Transcriptomic changes at the single cell level in varicose veins will allow us to identify key regulators effecting the different components of the varicose vein and their effects on EC-SMC crosstalk. Similarly, utilizing iPSCs to recapitulate the disease phenotype of varicose veins in vitro to screen for drugs will likely provide new insight into the pathogenesis of VV and benefit the development of therapies.

PI_NAMEs: NOISHIKI, CHIKAGE  (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Adult;Affect;bioinformatics pipeline;Biological Assay;Biology;Biomedical Research;Blood;Blood Vessels;Candidate Disease Gene;candidate validation;Cardiac Surgery procedures;cell type;Cells;Clinic;Complex;compression therapy;constriction;Data;debilitating symptom;Development;Digestion;Disease;disease model;disease phenotype;disease-in-a-dish;Drug Screening;Early treatment;Endothelium;Epigenetic Process;epigenomic profiling;Etiology;Extracellular Matrix Degradation;Extracellular Matrix Proteins;gain of function;Gene Expression Regulation;Genetic;genetic variant;Genome;genome wide association study;hemodynamics;Hypertension;Impairment;improved;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell technology;Inflammation;insight;intercellular communication;Matrix Metalloproteinases;Methods;Modeling;Molecular;Myography;novel;novel therapeutics;Operative Surgical Procedures;overexpression;Paracrine Communication;Pathogenesis;Pathology;patient derived induced pluripotent stem cells;Patients;Phenotype;Physiological;Play;pressure;Prevention;Proteins;Quality of life;recruit;Reflux;Regulation;Research Personnel;Resolution;Role;Sample Size;single cell genomics;single cell sequencing;single-cell RNA sequencing;Smooth Muscle Myocytes;Somatic Cell;stem cell model;Structural defect;Technology;therapy development;Tissues;trait;transcriptomic profiling;transcriptomics;Untranslated RNA;Validation;Varicosity;Vascular Diseases;Vein graft;Veins;Venous;Venous Pressure level

PROJECT_TITLE: Stem Cell Model of Varicose Veins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Cognitive and neuropsychiatric disorders have been linked to aberrant alternative splicing of various ion channels. Defects in ion channel splicing can dysregulate ion channel contributions to neuroplasticity. A mechanistic understanding of the activity-dependence of alternative splicing of ion channels would therefore advance our knowledge of the underlying causes of abnormal physiology and brain disorders.

PI_NAMEs: SUN, YU-CHI  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Action Potentials;Affect;Alternative Splicing;Animals;autism spectrum disorder;Biological Assay;Brain Diseases;cell type;Cells;channel blockers;Chemosensitization;Chronic;Cognition Disorders;Data;Defect;Dendrites;Dendritic Spines;Dependence;Engineering;Environment;Epilepsy;Exons;Family;Feedback;flexibility;Genes;Genetic Markers;Heterogeneity;Homer 1;Impairment;in situ sequencing;In Vitro;in vivo;Individual;Investigation;Ion Channel;Knowledge;large-conductance calcium-activated potassium channels;Learning;Left;Link;Measures;Mental disorders;Methods;Modification;Mus;neural circuit;Neuroanatomy;neuronal cell body;neuronal excitability;Neuronal Plasticity;Neurons;neuropsychiatric disorder;Pattern;Permeability;pharmacologic;Physiology;Potassium;Prevalence;Process;Property;Protein Isoforms;Reading;Regulation;Resources;RNA Splicing;SCN2A protein;screening;Seizures;Signal Pathway;Signal Transduction;Slice;Specificity;Synapses;Techniques;Testing;Tetrodotoxin;Transcript;transcriptome sequencing;Validation;visual deprivation;voltage

PROJECT_TITLE: Diverse Patterns of Activity-Dependent Alternative Splicing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SYRACUSE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: PROJECT NARRATIVE The androgen receptor (AR) plays a major role in transcriptional regulation and cell signaling in normal prostate cells, and is often dysregulated in most prostate cancers (PCa’s), thus AR is targeted for therapeutic treatment in PCa. Recent and emerging experimental data from the Bah-Kotula lab research collaboration has unveiled that Abl kinase-Interactor 1 (ABI1), a multi-isoform and scaffolding cytoskeletal adaptor protein, binds to AR and to chromatin in order to regular gene expression. However, the molecular underpinnings of this critical ternary interaction remain unknown; thus, I will elucidate the biophysical and structural basis governing the AR-ABI1- DNA axis, setting the stage for the development of novel therapeutics against PCa.

PI_NAMEs: KEMRAJ, ALLYSA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Affect;Affinity;Androgen Receptor;Apoptosis;Binding;Bioinformatics;Biological Process;Biology;biophysical techniques;Biophysics;C-terminal;Cell Nucleus;Cell Physiology;Cells;Chromatin;Collaborations;Complex;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;DNA;DNA Binding;DNA receptor;DNA Sequence;DNA-Binding Proteins;Estrogen Receptors;experimental study;Future;Gene Expression;Genetic Transcription;Goals;Growth;Homeobox;In Vitro;inhibitor;insight;intermolecular interaction;Investigation;Knowledge;Length;Ligand Binding Domain;Liquid substance;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;member;migration;Modality;Modeling;Molecular;Molecular Conformation;Mutagenesis;N-terminal;Neoplasm Metastasis;NMR Spectroscopy;novel;novel therapeutics;Nuclear;Nuclear Hormone Receptors;Outcome;Paper;Pathologic;Phase;Phosphotransferases;Physical condensation;Play;Proliferating;Proline-Rich Domain;Property;Prostate;prostate cancer progression;Prostate Cancer therapy;Prostatic Neoplasms;Protein Isoforms;Proteins;PXXP Motif;receptor binding;Regulation;Research;Role;scaffold;Scaffolding Protein;SH3 Domains;Signal Transduction;Specificity;spectrin SH3 domain binding protein 1;Spectrum Analysis;Structure;targeted treatment;Testing;Therapeutic Intervention;therapeutically effective;three dimensional structure;Transcriptional Regulation;tumor;tumor progression;Tumor Suppressor Proteins;Work

PROJECT_TITLE: A New Phase in ABI1 Biology: AR We Abl to Characterize the Intractable AR-DNA-ABI1 Axis?


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is a pervasive and increasingly common form of dementia with no current effective treatment options and thus, a critical need exists to understand how various cell types and genetic variants are implicated in the disease. Microglia have been associated with altered, pro-inflammatory phenotypes in AD, and defects in the fractalkine receptor, which is the primary axis for communication with neurons to attenuate the inflammatory response, have been associated with AD onset and progression. In this proposal, my goal is to utilize a human cellular model to elucidate the effects upon microglia with an AD-associated fractalkine receptor gene variant, both alone and in co-culture with neurons, to determine whether this variant may mediate neurodegenerative phenotypes and serve as a target for future AD intervention.

PI_NAMEs: TUTROW, KAYLEE  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;abeta accumulation;abeta oligomer;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein;Animal Model;Attenuated;Biological Assay;Brain;brain cell;Cell Communication;Cell Line;Cell model;cell type;Cells;Central Nervous System;clinically relevant;Coculture Techniques;Communication;CRISPR/Cas technology;CX3CL1 gene;cytokine;Data;Defect;Dementia;Development;Disease;disease model;disease phenotype;Disease Progression;effective therapy;Environment;Enzyme-Linked Immunosorbent Assay;Evaluation;Fractalkine;fractalkine receptor;Functional disorder;Future;Gene Expression Profile;Genes;Genetic Polymorphism;Genetic Transcription;genetic variant;Genome;Goals;Heterozygote;Homeostasis;Human;human induced pluripotent stem cells;hyperphosphorylated tau;Immune;immunocytochemistry;Impairment;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;innovation;insight;Interruption;Intervention;Late Onset Alzheimer Disease;Lead;Ligand Binding;Lipopolysaccharides;Macrophage;Maintenance;media use;Mediating;Microelectrodes;Microglia;migration;Migration Assay;Modeling;Morphology;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neuronal Differentiation;neuronal excitability;Neurons;novel;Onset of illness;Organoids;Outcome;Pathogenesis;Pathology;Pathway interactions;Phagocytosis;Pharmacologic Substance;Phenotype;receptor;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Surface;System;Tissues;transcriptome sequencing;TREM2 gene;Variant;Western Blotting;Work

PROJECT_TITLE: Investigating the role of the fractalkine axis in Alzheimer's Disease pathology using human induced pluripotent stem cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Contact PD/PI: Juliet King 1 PROJECT NARRATIVE Cleft lip and cleft palate (CL/P) are among the most prevalent birth defects globally, and especially threaten the wellbeing of families in countries with limited access to care. CL/P occurs when the oral and nasal passages fail to separate during fetal development, and our lab has found that cell adhesion plays a critical role in this process. This proposal will determine the molecular players and tissue layer-specific signaling that guides this process with the goal to improve future gene therapy techniques.

PI_NAMEs: KING, JULIET STANTON (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Actins;Address;Adherens Junction;adhesion receptor;Adhesives;afadin;Affect;Affinity;Award;Basal Cell;Binding;Biochemical;Biological;career;causal variant;Cell Adhesion;cell type;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Cellular biology;Cleft Lip;cleft lip and palate;Cleft Palate;Compensation;Complex;Congenital Abnormality;Country;craniofacial;Cytoskeleton;Data;Development;Developmental Biology;Developmental Process;Digit structure;Economics;Education;Embryonic Development;Epithelium;experimental study;Failure;Family;Fellowship;Fetal Development;Future;gain of function;Gene Deletion;Gene Expression;Gene Silencing;gene therapy;Genes;Genetic;genetic approach;Goals;Health Services Accessibility;Human;improved;Incidence;Individual;insight;interest;keratinocyte;knock-down;Knowledge;Laboratories;Live Birth;loss of function;Medical;Mentorship;Mesenchymal;Microscopy;migration;Modeling;Molecular;Morphogenesis;Mus;Mutate;Nasal cavity;National Research Service Awards;nectin;Nose;novel;Oral;oral biology;Oral cavity;oral cavity epithelium;palatal fusion;palatal shelves;Palate;palatogenesis;Pathology;Penetrance;Periderm;Personal Satisfaction;Physiological;Play;pre-doctoral;prevent;Process;programs;PVRL1;receptor;Receptor Signaling;Research Personnel;Role;Scientist;Shapes;Signal Transduction;skills;spatiotemporal;Stratum Basale;Techniques;Testing;Tissues;tool;Training;ultrasound;Work

PROJECT_TITLE: Determining the role of cell-cell adhesions in palate closure

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This research project aims to better understand how lymphatic flow is affected in patients with lymphedema and how surgical interventions like lymphaticovenous anastomoses (LVA) can improve their condition. By studying the mechanics of lymphatic vessels and how they adapt to different treatments, we hope to find more effective ways to treat lymphedema and improve the lives of millions of people worldwide who suffer from this condition. Ultimately, our research has the potential to contribute to better healthcare outcomes and enhance the quality of life for those affected by lymphedema.

PI_NAMEs: RYU, YOUNG JAE  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Acute;Address;Affect;Anastomosis - action;Attention;Automobile Driving;Back;Base Ratios;Biomechanics;Biomedical Engineering;cancer diagnosis;cancer therapy;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;care outcomes;Chronic Disease;Clinical;Clinical Data;clinical translation;clinically relevant;Collaborations;computer framework;Computer Models;Data;data modeling;Development;Drug Delivery Systems;Drug Targeting;effective therapy;Effectiveness;efficacious treatment;Ensure;Failure;Fluid Balance;Foundations;frontier;Geometry;Growth;Health;Hospitals;Human;Imaging Techniques;Immune;Immune response;improved;in vivo;in vivo imaging;Individual;Inflammation;innovation;insight;Intercellular Fluid;interdisciplinary approach;interstitial cell;Intervention;Investigation;Knowledge;Laws;Length;Limb structure;Lipids;Lower Extremity;Lymph;lymph flow;Lymph Node Dissections;Lymphatic;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic function;lymphatic pump;Lymphatic System;lymphatic vasculature;lymphatic vessel;Lymphedema;mechanical behavior;mechanical load;Mechanics;Mediating;Metabolic;Microsurgery;Modeling;Muscle;Neoplasm Metastasis;Nerve Degeneration;network models;non-invasive imaging;novel;Operative Surgical Procedures;optimal treatments;Outcome;outcome prediction;Pathologic;Patients;Persons;Physiological;Physiology;Plastic Surgical Procedures;Play;Population;pressure;Prevalence;Process;Proteins;proteostasis;Quality of life;Radiation therapy;Regulation;Research;Research Project Grants;response;Role;secondary lymphedema;shear stress;Site;Stress;Swelling;Therapeutic;Therapeutic Intervention;Time;Tissues;translational potential;Treatment outcome;treatment strategy;tumor

PROJECT_TITLE: Investigating the Effectiveness and Mechanisms of Lymphaticovenous Anastomoses (LVA) for Lymphedema Treatment: Integrating Computational Modeling with Clinical LVA Insights


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Physical Activity;Prevention

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE  The current proposal seeks to understand why metformin inhibits adaptations to aerobic exercise training in healthy, aged individuals. The project proposes that metformin negatively impacts calcium handling in skeletal muscle, which contributes to the inhibition of adaptations to aerobic exercise. Understanding these mechanisms could help determine strategies to maintain the positive effects of aerobic exercise training in healthy aging subjects, who may benefit from metformin treatment and, more importantly, who may not.

PI_NAMEs: O'REILLY, COLLEEN LOUISE (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Adverse effects;Aerobic;Aerobic Exercise;Affect;age effect;Aging;aging population;aging related;Agonist;Animals;Bioenergetics;Calcium;Calcium Signaling;calcium uniporter;Cardiac;Cell membrane;Cells;Chronic;Clinical Trials;Complex;Consensus;Coupled;Coupling;Data;Development;Drug Prescriptions;Endoplasmic Reticulum;Endothelium;Exercise;exercise intervention;exercise training;fibrosarcoma;Fluorescence Microscopy;Functional disorder;Generations;genetic selection;Health;healthspan;healthy aging;human subject;improved;in vivo;Individual;insulin sensitivity;interest;Intervention;Kinetics;Knowledge;Laboratories;life span;Light;Location;Measures;Membrane;Membrane Potentials;Metformin;Microscopy;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;mitochondrial permeability transition pore;Modeling;Muscle;muscle aging;Muscle Contraction;muscle form;Muscle function;Muscle Mitochondria;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Optics;Outcome;Oxidation-Reduction;Pathology;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Play;Production;Proteins;Proteome;Proteomics;Rattus;release of sequestered calcium ion into cytoplasm;Research;Research Personnel;Respiration;Respiratory physiology;response;Role;Skeletal Muscle;Specificity;Stress;Structure;Techniques;Testing;Tissues;Training;two-photon;uptake;Work

PROJECT_TITLE: Determining the influence of metformin treatment on mitochondrial calcium flux during aerobic exercise training of healthy, aging rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The scope of cocaine use disorder in the United States has escalated since the pandemic began in 2020. Currently, there are no pharmacotherapies for this disorder and public health concern. Understanding the role of phagocytic microglia in cocaine-seeking behaviors can reveal a possible underpinning of cocaine use disorder, thus advancing pharmacotherapy development opportunities.

PI_NAMEs: BELLINGER, TANIA JAZMINE (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 3-Dimensional;Abstinence;Acceleration;Address;Adult women;Animal Model;Anti-Inflammatory Agents;Area;Astrocytes;Behavior;Behavior Therapy;Brain;Cd68;Cell Enlargement;Cells;Central Nervous System;Cocaine;Cocaine Dependence;cocaine receptor;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;cohort;Complement;Coronavirus;COVID-19 pandemic;Data;Dependence;Development;Disease;Disease associated microglia;Disease Marker;Dopamine Agonists;Drug Addiction;drug of abuse;drug relapse;drug seeking behavior;Drug usage;Eating;Excision;experience;experimental study;Exposure to;FDA approved;Female;Fluorescence Microscopy;Foundations;Genes;Genetic;Glutamates;Goals;Home;Homeostasis;Immunohistochemistry;Impairment;in vivo;Individual;Inflammatory;insight;Laboratories;Lead;Macrophage;magnetic beads;Maintenance;male;Mediating;Membrane;Microglia;Molecular;Morphology;Mutation;Neuroglia;Neuroimmune;Neurons;neurotransmission;neutrophil;Nucleus Accumbens;overdose death;pandemic disease;Peptides;Phagocytes;Phagocytosis;Phagocytosis Inhibition;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Play;prevent;Process;Production;prospective;Proteins;Public Health;Publishing;Rattus;receptor;Relapse;relapse prevention;relapse risk;Research;Resolution;response;reward circuitry;Role;Self Administration;Signal Transduction;Sorting;Source;Structure;Synapses;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;United States;women subjects

PROJECT_TITLE: Structural and functional responses of nucleus accumbens microglia following long-access cocaine self-administration


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Narrative This proposal aims to elucidate the timeline of dopaminergic neuron specification and maturation during homeostasis and injury. Additionally, the research in this proposal will reveal genes that promote the creation of neurons that produce dopamine, a key signal in the nervous system. Uncovering and characterizing genes important for dopaminergic neuron regeneration using planarian flatworms could lead to a better understanding of successful brain regeneration and could lead to improvements in creating dopamine-producing neurons from stem cells for human therapies.

PI_NAMEs: CLAY, KENDALL BLEU (contact)

PROJECT_TERMS: Adult;Amputation;Amyloid beta-Protein Precursor;Animals;BHLH Protein;Binding;Birth;Birth Order;Body Size;Brain;Brain Injuries;brain repair;brain tissue;Cell Death;Cell Differentiation process;cell type;Cells;Central Nervous System;Cessation of life;Collaborations;Complex;Data;Development;Dopamine;dopaminergic neuron;Enzymes;Event;experience;fascinate;Future;Gene Expression;Genes;Genetic;Glean;Goals;Head;homeodomain;Homeostasis;Human;human stem cells;improved;in vivo;Individual;Injury;insight;knock-down;Knowledge;life span;Literature;Modeling;Molecular;Molecular Target;Natural regeneration;Nature;Nerve;Nerve Regeneration;nerve stem cell;Nervous System;neural;Neurodegenerative Disorders;neurogenesis;Neuroglia;neuron regeneration;Neurons;Organ;Organism;Outcome;Pathway interactions;Patients;Peripheral Nervous System;Planarians;Platyhelminths;Pluripotent Stem Cells;pre-clinical;Proliferating;protein protein interaction;Proteins;Protocols documentation;regenerative;regenerative therapy;repaired;Research;response;Role;Signal Transduction;Specific qualifier value;stem cell differentiation;stem cells;Stereotyping;Stroke;Structure;Time;timeline;Tissues;transcription factor;translational approach;Traumatic injury;Tyrosine 3-Monooxygenase;Work

PROJECT_TITLE: Characterizing genes that regulate dopaminergic neuron regeneration in the planarian brain


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Inflammatory Bowel Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The goal of this project is to characterize the transcriptional, epigenetic and functional changes that intestinal epithelial stem cells undergo during and after exposure to inflammatory granulomas that are generated during parasitic helminth infection. In the short term, the data generated in this study will reveal whether intestinal stem cells maintain an epigenetic memory of inflammation and will enable the identification of the signaling pathways and molecular regulators implicated in this process. In the long term, this work will improve our understanding of how inflammation impacts intestinal stem cells’ function and enhance our knowledge of their role in inflammation- driven diseases such as Crohn’s disease and ulcerative colitis.

PI_NAMEs: VIRAGOVA, SARA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;Acceleration;Acute;Adult;adult stem cell;Affect;airway epithelium;Allergic inflammation;Animal Model;Animals;ATAC-seq;Bacteria;base;Bioinformatics;Biological Assay;Biology;Celiac Disease;Cell Physiology;Cell Separation;Cell Surface Proteins;Cells;Chromatin;collaborative environment;Columnar Cell;CRISPR/Cas technology;Crohn's disease;cytotoxic;Data;Data Set;Digestion;Disease;Enabling Factors;Enteral;epigenetic memory;Epigenetic Process;epigenomics;Epithelial Cells;epithelial stem cell;Epithelium;epithelium regeneration;Exposure to;Fellowship;fetal;fitness;Fluorouracil;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genomic Segment;Genomics;Goals;Granuloma;gut inflammation;helminth infection;Helminths;Homeostasis;Human body;Immune;Immune response;Immunity;Immunology;improved;In Vitro;in vitro testing;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;insight;Institution;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Kinetics;Knowledge;Laboratories;LGR5 gene;Malignant Neoplasms;member;Memory;memory encoding;Mentorship;Molecular;Morphology;multidisciplinary;multiple omics;Mus;Natural regeneration;Nematospiroides dubius;nutrient absorption;Organ;Organism;Organoids;overexpression;pathogen;Pathology;Phenotype;Poison;Positioning Attribute;Process;Professional Competence;programs;Proliferating;Radiation;Recovery;Regenerative capacity;Research;Research Personnel;Resolution;response;Role;Signal Pathway;single-cell RNA sequencing;Skin;Small Intestines;spheroids;stem;stem cell biology;stem cell function;stem cells;Stimulus;Testing;tissue regeneration;Tissues;Training;transcription factor;transcriptome sequencing;Transgenic Animals;Ulcerative Colitis;Virus;Work;wound healing;XCL1 gene

PROJECT_TITLE: Examining the role of epigenetic memory in intestinal regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Both mitochondrial and blood brain barrier (BBB) dysfunction have been independently associated with neuropsychiatric illness. Based on our recent publications and compelling preliminary data, we propose that in a relatively common genetic cause of neuropsychiatric illness, mitochondrial dysfunction contributes to BBB dysfunction and presents a novel therapeutic target. If our hypothesis is correct, this finding can shift paradigms for inflammatory influences on brain development and function based on the synergistic influences of relatively subtle structural and energetic weaknesses in the BBB.

PI_NAMEs: ALVAREZ, JORGE IVAN (contact);ANDERSON, STEWART A

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 22q11.2;3' Untranslated Regions;Agonist;Animals;Area;autism spectrum disorder;Behavioral;behavioral phenotyping;Bezafibrate;Biogenesis;Birth;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Cells;blood-brain barrier function;Brain;brain health;Cell Line;cell type;Cells;Central Nervous System;clinically relevant;Complex;Data;Defect;Development;DiGeorge Syndrome;Disease;Endothelium;Exhibits;experimental study;FDA approved;functional restoration;Gene Deletion;Genes;Genetic;Heterozygote;Hippocampus;Immune;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Inflammatory;Intellectual functioning disability;Intervention;knock-down;Knockout Mice;lymphoblastoid cell line;Measures;Memory impairment;Mental disorders;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mouse model;Mus;Mutation;nervous system development;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuroinflammation;neuropsychiatric disorder;neuropsychiatry;neurovascular;new therapeutic target;Nicotinamide Mononucleotide;novel;novel therapeutics;Oxidative Phosphorylation;Peripheral;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phenotype;Process;Production;Property;Proteins;Publications;Publishing;Risk;Schizophrenia;schizophrenia risk;social;synergism;System;Testing;Therapeutic;therapeutic target;Therapeutically Targetable;Tight Junctions;Variant;Work

PROJECT_TITLE: Mitochondrial influences on blood brain barrier function and neuropsychiatric illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-M (91)]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Mitochondrial dysfunction and neuroinflammation are major hallmarks of brain aging and age-related neurodegenerative diseases, such as Alzheimer’s disease, and although abnormal mitochondrial function appears to precede inflammation, it remains unclear if or how mitochondrial dysfunction initiates inflammation in brain aging and Alzheimer's disease. This project will explore the potential role of mitochondria-derived double-stranded RNA, which may be released due to mitochondrial dysfunction, in activating inflammatory signaling as an early driver of age/Alzheimer’s disease-related neuroinflammation. The results may provide insight into the biology of brain aging and the development of Alzheimer’s disease.

PI_NAMEs: DOSER, RACHEL  (contact)

PROJECT_TERMS: Affect;Age;age related;age related neurodegeneration;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;anti aging drug;Autoimmune Diseases;Autoimmunity;BAX gene;Binding;Bioinformatics;Biology;Brain;Brain Pathology;Caenorhabditis elegans;career;Cell Culture Techniques;Cell Death;Cell Reprogramming;Central Nervous System;Chromosomes;Chronic;Clinical;Clinical Data;cognitive function;Colorado;cytokine;Cytoplasm;Data;Data Science;Data Set;design;Development;Disease Progression;DNA Damage;Double-Stranded RNA;drug preservation;Event;experience;experimental study;Fellowship;Fibroblasts;Functional disorder;Gene Expression Profile;Genetic;Genetic Transcription;Genus Hippocampus;hallmarks of aging;Health;healthspan;Human;human disease;human old age (65+);Immune;immune activation;Immune response;immune RNA;Immunologic Markers;Impaired cognition;In Vitro;in vivo;Inflammation;Inflammatory;Innate Immune Response;insight;Interdisciplinary Study;Intervention;Learning;Link;Longevity;Malignant Neoplasms;Measurement;Measures;Mentors;Metabolic;mimetics;Mitochondria;mitochondrial dysfunction;mitochondrial genome;Mitochondrial RNA;Modeling;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;Outcome;Patients;pharmacologic;Postdoctoral Fellow;prevent;Production;Proteins;Research;Research Personnel;Research Training;response;RNA;RNA Editing;RNA immunoprecipitation sequencing;Role;Scientist;sensor;Signal Transduction;Site;skill acquisition;skills;Source;Spirometry;Stress;tau Proteins;Techniques;Testing;Training;Transcript;transcriptome;Translational Research;Universities

PROJECT_TITLE: Mitochondria-derived dsRNA in brain aging and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Machine Learning and Artificial Intelligence;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: This research project examines the role of ECM-mediated inter-tissue adhesion in early spinal column development. The project seeks to understand how the neural tube adheres to the flanking mesoderm with a medial-lateral stress gradient while simultaneously sliding posteriorly relative to the mesoderm. The proposed research utilizes a unique combination of live imaging, spatially and temporally controlled genetic manipulation and a new in vivo single molecule spectroscopy and machine learning protocol to elucidate the molecular, cellular and tissue level mechanisms that orchestrate early development of the spinal column.

PI_NAMEs: HOLLEY, SCOTT A (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: 3-Dimensional;4D Imaging;Actomyosin;Address;Adhesions;Adhesives;Affinity;Animals;Behavior;Bilateral;Biological Assay;Biology;Biomechanics;Biophysics;Cell Adhesion;Cell Surface Receptors;Cells;Chemicals;Computer Models;Congenital Abnormality;Congenital Scoliosis;Couples;Cytoskeleton;data analysis pipeline;Development;Diffusion;ECM receptor;Embryo;Engineering;Ensure;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Failure;Fibronectin Receptors;Fibronectins;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;gastrulation;Genetic;genetic manipulation;Glues;glycoproteomics;glycosylation;Growth;Heat-Shock Response;Image;in vivo;indexing;Integrins;Joints;Laboratory Finding;Lateral;Left;Link;Liquid substance;Machine Learning;Mammalian Cell;Measurement;Measures;Mechanics;Medial;Mediating;Mesoderm;Modeling;Molecular;Molecular Conformation;molecular dynamics;Morphogenesis;Motility;Motion;Movement;mutant;neural;Neural tube;novel;Paraxial Mesoderm;Pattern;Phenotype;prevent;Process;progenitor;Proteins;Proteomics;Protocols documentation;Research;Research Project Grants;Role;scoliosis;Shapes;single molecule;single-molecule FRET;Site;Slide;Somites;Spectrum Analysis;Spinal Dysraphism;Stress;System;Techniques;Testing;Time;Tissues;Transgenes;Transgenic Organisms;Vertebral column;vertebrate embryos;Viscosity;Zebrafish;zebrafish development

PROJECT_TITLE: A Cross-scale analysis of cell-ECM adhesion in early spinal column development

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Precision Medicine;Rare Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: SURGERY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: Project Narrative Hepatocellular carcinoma (HCC) remains a disease with a dismal prognosis and limited therapeutic options. The proposed study aims to establish the novel FAK-CTGF axis in the promotion of HCC and the use of CTGF as a biomarker marker for FAK expression. Success of this study will elucidate the pathogenesis of FAK-driven HCC and could have direct clinical applications.

PI_NAMEs: KEATING, CLAUDIA ROSE (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Aftercare;angiogenesis;anti-cancer research;beta catenin;Biological Markers;biomarker discovery;biomarker identification;Biopsy;cancer type;candidate marker;Cell Differentiation process;cell growth;Cell secretion;Clinic;Clinical;clinical application;Clinical Trials;cohort;connective tissue growth factor;Data;Death Rate;Development;Diagnosis;Disease;Dose;Focal Adhesion Kinase 1;Growth;Growth Factor;Growth Factor Overexpression;Hemorrhage;hepatocellular carcinoma cell line;HIF1A gene;High Prevalence;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo;in vivo Model;innovation;knock-down;liver cancer model;liver imaging;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Messenger RNA;Molecular;mouse model;Mus;Needles;new therapeutic target;novel;Oncogenic;overexpression;Pathogenesis;Pathway interactions;Patient Selection;Patients;personalized medicine;pharmacologic;Phosphorylation;predictive marker;Primary carcinoma of the liver cells;Prognosis;Proliferating;Protac;Protein Kinase;Proteins;PTK2 gene;Regulation;Research;Risk;Role;Sampling;Serum;small hairpin RNA;STAT3 gene;success;Surrogate Markers;targeted agent;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapy outcome;Time;Tissues;transcriptome sequencing;tumor;tumor growth;Tumor Promoters;Tumor Promotion;Work;α-Fetoproteins

PROJECT_TITLE: Define the molecular mechanisms in and identify biomarkers for FAK-driven hepatocellular carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Substance use disorder affects 8.5% of the United States population and stressful life experiences can promote relapse, resulting in re-initiation of drug taking in abstinent individuals. This proposal seeks to expand our understanding of the mechanism by which the stress hormone, corticosterone, activates the endocannabinoid signaling system and promotes drug seeking. Moreover, this study will advance an understanding of the mechanisms through which stress guides behavior under healthy and pathological conditions.

PI_NAMEs: LASKOWSKI, LAUREN J (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Abstinence;Affect;antagonist;Axon;Behavior;Behavioral;Bilateral;Biosensor;Brain;cannabinoid receptor;CNR1 gene;Cocaine;cocaine seeking;Collaborations;Corticosterone;Coupled;Couples;Data;design;Development;Disease;Disease remission;Doctor of Philosophy;drug relapse;drug seeking behavior;endocannabinoid signaling;Endocannabinoids;Environment;Experimental Designs;Faculty;Fellowship;Fiber;Frequencies;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Gene Expression;Glucocorticoid Receptor;Glucocorticoids;Goals;Heterotrimeric GTP-Binding Proteins;hippocampal pyramidal neuron;Hormones;Human;Hydrocortisone;Image;in vivo;Individual;inhibitor;Injections;insight;instrumentation;Interneurons;intraperitoneal;Knowledge;Laboratories;Learning;Lipase;lipoprotein lipase;Measures;Medial;Mediating;medical schools;Membrane Proteins;Mentorship;meter;Mifepristone;Mineralocorticoid Receptor;Modeling;Motivation;neural circuit;neuronal excitability;Neurons;neurotransmission;non-genomic;Nucleus Accumbens;Output;Pathologic;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phospholipase C;Photometry;Population;postsynaptic;Prefrontal Cortex;Pyramidal Cells;Rattus;receptor;recruit;Regulation;Relapse;Research;Research Personnel;Research Project Grants;response;Rodent;Scientist;Self Administration;Signal Pathway;Signal Transduction;Slice;Stress;Stressful Event;Substance Use Disorder;Synapses;Synaptic Transmission;System;Technical Expertise;Testing;Therapeutic Intervention;Time;Training;United States;Whole-Cell Recordings;Wisconsin;Work

PROJECT_TITLE: Involvement of Gq Signaling in the Mobilization of 2-Arachidonoylglycerol by Corticosterone in the Prefrontal Cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Orphan Drug;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE OI patients experience brittle bone and recurrent fractures due to mutations impacting type I collagen production, modification, or trafficking. Recent work has identified that misfolded type I collagen accumulates in the ER and causes ER stress in certain individuals with OI -- it is not known if this phenomenon is common to all forms of OI or if the process interferes with bone active therapeutics used to treat OI. This proposal will establish that ER stress as a clinically important, genotype dependent feature of OI and establish preclinical data for a new precision strategy to treat OI.

PI_NAMEs: KOT, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Acids;Affect;alternative treatment;American;Apoptosis;arm;ATF6 gene;autosomal dominant mutation;Biological Assay;Birth;bisphosphonate;bone;Bone Density;bone mass;bone strength;Calcium;Calvaria;Cells;cellular targeting;Clinical;Clinical Research;COL1A1 gene;COL1A2 gene;Collagen;Collagen Type I;Collection;Complex;Connective Tissue Diseases;Cytomegalovirus;Data;Disease;dominant genetic mutation;ECM receptor;Endoplasmic Reticulum;endoplasmic reticulum stress;Endosteum;Etiology;Exhibits;experience;experimental study;Extracellular Matrix;Female;Femur;Fracture;fracture risk;Functional disorder;Genes;Genetic;Genetic Determinism;Genetic Transcription;Genotype;Glycine;Goals;Human;Impairment;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;International;Knowledge;Label;Lead;Ligands;Membrane;Modeling;Modification;Molecular Chaperones;Morbidity - disease rate;mouse model;Mus;Mutation;novel therapeutic intervention;novel therapeutics;Osteoblasts;Osteocalcin;Osteochondrodysplasias;Osteoclasts;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;osteoprogenitor cell;Parathyroid Hormone Receptor;pathologic bone resorption;Patient Care;patient subsets;Patients;Perinatal mortality demographics;Periosteum;Phenotype;pre-clinical;Process;Procollagen;Production;protein folding;Proteins;PTH gene;receptor;Receptor Cell;receptor function;Recurrence;Registries;Reporting;response;RNA Splicing;Signal Transduction;skeletal dysplasia;Stress;stress reduction;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Therapeutic Uses;trafficking;transcriptome sequencing;Transforming Growth Factor beta;Transmission Electron Microscopy;treatment response;treatment strategy;Type I Procollagen;Uncertainty;United States;Visualization;Vitamin D;Western Blotting;Work

PROJECT_TITLE: Genetic determinants of endoplasmic reticulum stress in OI and its consequences on cellular receptors


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Positive childhood experiences prevent and mitigate the effects of adverse childhood experiences and lead to improved adult health outcomes. The HOPE framework is a relationship-based approach which transforms interactions between providers and parents, opening up dialogue to focus on a family’s assets and strengths, bringing in family agency and ultimately leading to an alignment of the agency’s goals and family’s priorities. The goal of the HOPE Regional Satellite Meetings is to catalyze and support organizational transformation and adoption of HOPE.

PI_NAMEs: SEGE, ROBERT D (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adopted;Adoption;Adult;adverse childhood events;Affect;anti-racism;Australia;Award;Awareness;Behavioral Risk Factor Surveillance System;Biological;California;Caring;Certification;Child;Childhood;Climate;Clinical;Communities;Data Analyses;Decision Making;Development;Diffusion of Innovation;Educational workshop;Emotional;Environment;Equity;Evaluation;experience;Family;family support;Feedback;Fostering;Goals;Growth;Health;implementation barriers;implementation facilitators;implementation science;improved;indexing;Individual;innovation;interest;Knowledge;Learning;learning progression;Link;Longitudinal Studies;Massachusetts;Measures;meetings;Mental Health;Modeling;National Institute of Child Health and Human Development;Outcome;Parents;Persons;physical conditioning;Play;Policies;poor health outcome;prevent;Process;programs;promote resilience;Provider;Reporting;Research;resilience;Resources;Services;SET Domain;social;Stress;Surveys;symposium;Tennessee;Training;Translational Research;United States;uptake;Wisconsin;Work;Youth

PROJECT_TITLE: 2024 HOPE Summit

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Prevention

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: PROJECT NARRATIVE Increased mental health problems are present in developmental language disorder (OLD) and emotion regulation difficulties are one potential contributor to their development. This project will investigate the emotion regulation of children with OLD in comparison to children with typical development during both linguistically demanding and domain-general tasks using self-report, behavioral, and physiological indicators. The project will contribute to fundamental knowledge about the ER functioning of children with OLD, inform the multimethod assessment of ER in populations with language deficits, support early identification of emotional problems in children with OLD, and possibly allow for earlier targeted interventions to prevent and mitigate future mental health problems and/or disorders.

PI_NAMEs: BERRIER, TAYLOR BRYANT (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Anxiety;Area;Behavior;Behavioral;behavioral response;career development;Child;Clinical;clinically relevant;Code;Cognitive;Communication;Data Set;Development;Diagnostic;Disease;Distress;Early identification;emotion regulation;Emotional;Emotions;Environment;Exhibits;experience;Fellowship;Frustration;Future;Goals;Heart;indexing;Individual;Informal Social Control;informant;innovation;insight;Intervention;Knowledge;Label;Language;Language Development Disorders;Language Disorders;Leadership;Linguistics;Literature;Measurement;Measures;Mediating;Mental Depression;mental development;Mental disorders;Mental Health;Mentorship;Methodology;Methods;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;neurobiological mechanism;parent grant;Parents;Patient Self-Report;peer;Physiological;Physiological Processes;Physiology;Population;Positioning Attribute;Postdoctoral Fellow;prevent;Prevention;Process;Psychological Theory;Recovery;Reporting;Research;Research Personnel;Resources;response;responsible research conduct;Rest;Risk;Risk Factors;Science;skills;Specific qualifier value;Statistical Data Interpretation;Strategic Planning;Taxes;theories;Training;training opportunity;United States National Institutes of Health;Well in self;Work

PROJECT_TITLE: Emotion Regulation in Children with Developmental Language Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Disorder-containing protein domains inherently have a dynamic nature and play important roles in numerous physiological processes as well as pathological states. In this work, I propose an innovative workflow for the high-throughput identification and optimization of modulators for two distinct, dynamic transcriptional coactivator domains, KIX and HEAT, the results of which will directly contribute the cancer therapeutics. This workflow will be pivotal for the successful targeting of conformationally dynamic proteins, a class of proteins that is known to contribute to numerous diseases but is largely considered to be ‘undruggable’.

PI_NAMEs: CROSKEY, AYZA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acids;Allosteric Site;Binding;Binding Sites;Biological Assay;biophysical techniques;c-myc Genes;Chemicals;Cholesterol;Communication;Computer Analysis;Coupled;Data;Disease;Disease Pathway;drug discovery;drug standard;Drug Targeting;EP300 gene;experimental study;Fluorescence Polarization;follow-up;Genetic Screening;Genetic Structures;Genetic Transcription;Goals;high throughput screening;Homeostasis;Human;innovation;lead optimization;Letters;Libraries;Ligand Binding;Ligands;Link;Lipids;Malignant Neoplasms;Measures;Mediating;member;Metabolic Diseases;Methods;Molecular Conformation;Nature;novel;Pathologic;Pattern;Physiological Processes;Play;Procedures;Protein Dynamics;protein function;Protein NMR Spectroscopy;protein protein interaction;Proteins;Proteome;Reporting;Research;Role;Scanning;screening;Site;small molecule;small molecule inhibitor;Structural Models;Structure;System;Tertiary Protein Structure;Therapeutic;therapeutic candidate;therapeutic development;thermostability;three dimensional structure;tool;Transcription Coactivator;transcription factor;Transcription Process;Transcriptional Regulation;Translating;TRRAP gene;Work

PROJECT_TITLE: Advancing drug discovery for protein domains containing intrinsically disordered regions


NIH_SPENDING_CATS: Aging;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Nashville

ORG_DEPT: CHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project aims to predict the impact of oxidative stress on human proteins via a novel deep learning methodology. The deep learning approach involves encoding atomic protein geometry using a graph transformer-based autoencoder, enabling the biochemical information contained within known protein structures to be applied to tasks with limited training examples. Through this project, we will uncover functional insights into aging-related ailments, identify potential drug targets, and validate the computational findings through collaboration with an experimental lab.

PI_NAMEs: BELL, ERIC WILLIAM (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acetylation;Age;Aging;aging mechanism;aging related;aging related disease;Alzheimer's Disease;Amino Acids;Architecture;Artificial Intelligence;artificial intelligence method;Attention;autoencoder;Benchmarking;Binding Sites;Biochemical;Biochemical Phenomena;Bioinformatics;Carbohydrates;Case Study;Cells;cohort;Collaborations;Communities;Complement;Complex;cost;Cysteine;Data;Data Set;Databases;deep learning;design;detection method;Development;Disease;Drug Targeting;Ensure;Environment;Exposure to;Face;Future;Geometry;Graph;hallmarks of aging;Human;Individual;insight;interest;laboratory experiment;Length;Ligand Binding;Ligands;Lipids;Mass Spectrum Analysis;method development;Methodology;Methods;Modeling;Modification;Molecular;neural network;novel;Nucleotides;Oxidants;oxidation;oxidative damage;Oxidative Stress;Pathway interactions;Persons;Pharmaceutical Preparations;Phosphorylation;Post Translational Modification Analysis;Post-Translational Protein Processing;Procedures;Protein Biochemistry;protein function;protein structure;Proteins;Proteome;Research;Resolution;Scanning;Scheme;Scientist;Site;Source;Specific qualifier value;Structure;Surveys;therapeutic development;therapeutic target;tool;Training;vector;Work

PROJECT_TITLE: Analysis of oxidative stress through deep atomic embeddings


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a progressive neurodegenerative disease primarily affecting individuals over the age of 65. In this proposal, we aim to understand drivers of AD pathology seeding to improve upon and increase accessibility of current model systems AD.

PI_NAMEs: KASEN, ALYSA MARIE (contact)

PROJECT_TERMS: Abeta synthesis;Adult;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Animal Model;Astrocytes;Binding;Biological Models;Biotechnology;Brain;cell type;Cells;cofactor;Collaborations;Cryoelectron Microscopy;Data;Deposition;Development;Diagnosis;Diagnostic;Disease;DNA Sequence Alteration;Environment;Fellowship;Frontotemporal Dementia;Future;Generations;Goals;Heparin;Human;human disease;human old age (65+);Image Analysis;Impaired cognition;improved;In Vitro;in vivo;Individual;Injections;innovation;Insecta;Knock-in Mouse;Maps;Methods;Microtubules;Modeling;Modification;Molecular Conformation;Mus;Negative Staining;Nerve Degeneration;Neurites;Neuroanatomy;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurons;next generation;Oligodendroglia;Oral;Pathogenicity;Pathologic;Pathology;Patients;Pattern;permissiveness;Persons;Phosphoric Monoester Hydrolases;Play;Post-Translational Protein Processing;posters;Proteins;Proteomics;Protocols documentation;rare variant;Recombinants;Research;Research Institute;Role;Running;Senile Plaques;Shapes;Source;structural biology;Structure;tau aggregation;tau conformation;tau mutation;tau Proteins;tau-1;Tauopathies;Technical Expertise;therapeutic development;Training;Transgenic Mice;United States;Wild Type Mouse;Work

PROJECT_TITLE: Identifying Determinants of Tau Pathology Seeding


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Craniofacial birth defects commonly arise due to altered patterning of the cranial neural crest-derived cells that form the jaw skeleton and connective tissues. This project investigates two novel jaw-specific mechanisms that regulate the proportion of skeletal and connective tissue cell types in the developing face. Findings from these studies will inform how altered Hedgehog signaling and chromatin accessibility contribute to a variety of birth defects affecting the jaw.

PI_NAMEs: PAULISSEN, ERIC  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;antagonist;Antibodies;ATAC-seq;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Binding;bone;California;Cartilage;cartilage development;Cell membrane;cell type;Cells;Cephalic;ChIP-seq;Cholesterol;Cholesterol Homeostasis;Chromatin;cofactor;Communities;Congenital Abnormality;Connective Tissue;Connective Tissue Cells;craniofacial;craniofacial development;Data;Defect;design;Development;DNA Binding Domain;Enhancers;Ensure;Enzymes;Equilibrium;Erinaceidae;experimental study;Face;Family;Fellowship;FOXC1 gene;FOXP2 gene;gene function;Generations;Genes;Genetic;Gland;Goals;Health Sciences;Human;Institution;Jaw;Jaw Abnormalities;Ligaments;Liver;Measures;Mediating;Mentorship;Modification;Mus;Musculoskeletal;mutant;Nervous System;Neural Crest;novel;NR5A2 gene;Nuclear Hormone Receptors;Nuclear Orphan Receptor;Oral;oral ectoderm;Pattern;Phenotype;Positioning Attribute;professor;Proteins;receptor;Regulation;Repression;Research;Research Project Grants;Research Training;RNA;Role;Salivary Glands;Scientist;Shapes;single cell sequencing;single-cell RNA sequencing;skeletal;skeletal tissue;Skeleton;smoothened signaling pathway;spatiotemporal;stem cells;System;Tendon structure;tenure track;Testing;Tissues;transcription factor;Universities;XCL1 gene;Zebrafish

PROJECT_TITLE: The roles of Hsd3b7 and Foxp2 in Lower Jaw Development


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative Frontotemporal dementia is the second most common presenile dementia but the underlying pathogenic mechanisms remain largely unknown. We will use fruitfly Drosophila as a model organism to investigate molecular mechanisms underlying the roles of innate immunity in poly(GR)-induced neurodegeneration. If successful, these studies will provide novel mechanistic insights into C9ORF72-FTD and suggest potential targets for therapeutic intervention.

PI_NAMEs: GAO, FEN-BIAO  (contact);SILVERMAN, NEAL

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Address;Affect;Age;Alzheimer's Disease;American;Amyotrophic Lateral Sclerosis;Animal Model;Anterior;anti-microbial peptide;Applications Grants;Atrophic;Attention;Biological Models;Brain;C9ORF72;Cell model;Cells;Clinical;Collaborations;cooking;Dementia;Dipeptides;Disease;DNA Sequence Alteration;Drosophila genus;Empathy;Exhibits;experimental study;Eye;fly;Foundations;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genes;Genetic;genetic approach;Homologous Gene;Human;Impaired cognition;Induced Neurons;induced pluripotent stem cell;insight;Introns;Investigation;knock-down;Language;model organism;Modeling;Molecular;Motor Neurons;Muscular Atrophy;Natural Immunity;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Differentiation;Neurons;neurotoxicity;new therapeutic target;novel;Paralysed;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Personality;Persons;PGRN gene;Play;Presenile Dementia;Production;Proteins;Recording of previous events;RNA;Role;Social Behavior;Solid;System;targeted treatment;Temporal Lobe;Testing;Therapeutic Intervention;Toxic effect;Translating

PROJECT_TITLE: Mechanistic Investigation of Innate Immunity in a Drosophila Model of Frontotemporal Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-B (02)]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Despite mounting genomic and transcriptomic evidence linking alternative splicing to autism spectrum disorder (ASD), the underlying molecular mechanisms remain elusive. This project employs single nucleus long-read sequencing to identify, quantify, and localize full-length isoforms into cell populations of the postnatal prefrontal cortex, in individuals with and without a diagnosis of idiopathic ASD. Gaining insight into how brain-expressed isoforms contribute to cell types, interact in biological pathways, and are dysregulated in the context of ASD, will further our mechanistic understanding of brain function.

PI_NAMEs: MARGOLIS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Age;Alternative Splicing;Architecture;Astrocytes;Autism Diagnosis;autism spectrum disorder;Autopsy;bioinformatics tool;Biological;biological age;Biological Process;biological sex;Brain;Brain region;brain tissue;Brodmann's area;career;case control;Categories;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chromatin;Complex;Consensus;Data;Data Set;Development;Diagnosis;differential expression;dimension reduction;Disease;disease phenotype;DNA Sequence Alteration;doctoral student;excitatory neuron;Exons;Foundations;frontal lobe;Functional disorder;functional genomics;Future;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;genetic risk factor;Genetic Transcription;genome wide association study;Genomics;Heritability;high risk;Human;Human Genetics;human genomics;human tissue;Individual;individuals with autism spectrum disorder;Inflammatory;insight;Introns;Length;Link;Logistic Regressions;Maps;Mentors;Mentorship;Messenger RNA;Microglia;Mission;Molecular;National Institute of Mental Health;neurobehavioral;Neurobiology;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Physicians;Physiology;Population;postnatal;postnatal human;Prefrontal Cortex;Process;Protein Isoforms;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Scientist;Signal Transduction;single cell sequencing;Solid;Structure;System;Technology;Testing;Tissues;Training;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Mapping cell type specific isoform diversity in the human brain: dissecting mechanisms of alternative splicing in ASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Bone metastasis is an incurable condition, and current standard of care disrupts estrogen signaling in the bone microenvironment leading to bone-related morbidity, which if left untreated may accelerate metastasis. This proposal aims to investigate the use of a novel endocrine therapy called Elacestrant which may lessen destruction of the bone microenvironment while still eliminating metastatic cells, due to context-dependent selective ER agonist/antagonist activity. The proposed study will expand the knowledge of new-generation endocrine therapies in the context of cancer and the cancer microenvironment, as well as yield clinically actionable data which may be rapidly translated to patient care.

PI_NAMEs: ZBORIL, EMILY KATE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Acceleration;Affect;Agonist;antagonist;Aromatase Inhibitors;Binding;Biology;bone;bone cell;Bone Matrix;Bone Resorption;Breast;cancer cell;carcinogenesis;CDK4 gene;Cell Culture Techniques;Cell Cycle;Cell Cycle Arrest;cell type;Cells;ChIP-seq;Chromatin Remodeling Factor;Clinical;clinically actionable;Combined Modality Therapy;cytotoxic;Data;Dependence;Diagnosis;Disease;Disease Progression;DNA;Doctor of Philosophy;efficacy evaluation;Endocrine;Equilibrium;ESR1 gene;Estrogen Antagonists;estrogen disruption;Estrogen receptor positive;Estrogen Receptors;Estrogen Therapy;Estrogens;Evaluation;Exhibits;experience;FDA approved;Frequencies;Fulvestrant;Generations;Genes;Genetic Transcription;Genomics;high throughput screening;Homeostasis;hormone receptor-positive;hormone therapy;iliac artery;Immunoprecipitation;improved;In Vitro;in vivo;inhibitor;Injections;insight;Knowledge;Lead;Left;Lytic Metastatic Lesion;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metastatic breast cancer;Metastatic Neoplasm to the Bone;Modeling;Morbidity - disease rate;mouse model;multidisciplinary;Mus;mutant;Mutation;nano-string;Neoplasm Metastasis;non-genomic;novel;novel therapeutics;Osteoblasts;Osteoclasts;Patient Care;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pre-clinical;Pre-Clinical Model;Prognosis;Progression-Free Survivals;Proliferating;Proteins;Receptor Signaling;recruit;Recurrence;Refractory;Response Elements;Rodent Model;Signal Transduction;standard care;standard of care;Survival Rate;targeted treatment;therapy design;Training;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translating;tumor microenvironment;tumorigenesis;Universities;Virginia;Work

PROJECT_TITLE: Elacestrant in breast cancer bone metastases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Autoimmune Disease;Crohn's Disease;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease

ORG_CITY: CHARLESTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative Crohn’s disease is a chronic and deadly gastrointestinal inflammatory disorder with no cure, and it continues to impose substantial burdens on patients and healthcare systems globally. Through this research proposal, we aim to define the intricate role of Myosin 5b in governing microvilli assembly and its potential implications on intestinal epithelial susceptibility to Crohn’s disease associated pathobionts. The findings from this study have the potential to provide a new understanding of Crohn's disease, potentially identifying novel biomarkers to enable early diagnosis and targeted therapeutic interventions.

PI_NAMEs: DOOLEY, SARAH A (contact)

PROJECT_TERMS: Acinetobacter;Actins;Activities of Daily Living;Adhesions;Adult;Affect;Animal Model;Ankyrin Repeat;Apical;apical membrane;Area;Bacterial Adhesion;Bacterial Infections;Brush Border;Cells;cellular microvillus;Chronic;Complex;Crohn's disease;Cytoplasm;Data;Disease;disorder subtype;Early Diagnosis;Economic Burden;Enterocytes;Epithelial Cells;Epithelium;Escherichia coli;Etiology;Exhibits;gastrointestinal;Genetic;gut bacteria;Health;healthcare burden;Healthcare Systems;Host Defense;Human;Immunologics;in vitro Model;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;intestinal epithelium;Intestines;Klebsiella pneumoniae;Length;Link;Mediating;microbial;Molecular Motors;mouse model;Movement;Mucins;Mus;Myosin ATPase;novel;novel marker;nutrient absorption;Organoids;pathobiont;Pathogenesis;pathogenic bacteria;Pathogenicity;Patients;Physiological;Predisposition;Prevalence;protein complex;Proteins;Publications;Regulation;Research Proposals;Role;Signal Transduction;Stimulus;Surface;targeted treatment;Tertiary Protein Structure;Testing;Therapeutic Intervention;Tissues;trafficking;Ulcerative Colitis;United States;USH1C gene;Water

PROJECT_TITLE: Elucidating the role of Myosin 5b in microvilli assembly and in the setting of inflammation


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE GCN2 control nonderepressible 2 (GCN2) is a highly conserved amino acid sensor that enables cells to respond to nutrient stress by modulating mRNA translation. While the GCN2-eIF2 pathway is known to play a critical role in human developmental disorders and endothelial cell dysfunction, the importance of mRNA translation in the pathogenesis of GCN2-related disorders is unknown. Therefore, I will combine human induced pluripotent stem cell technology with high throughput translatome analysis to uncover novel GCN2 targets that will provide insight into new candidates for treating endothelial-related diseases.

PI_NAMEs: TOBOZ, PHOENIX  (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: acetyl-LDL;acid stress;Amino Acids;Binding;Biochemical;Biological Assay;Blood Vessels;cadherin 5;candidate identification;Cell Differentiation process;Cell Maintenance;cell motility;Cell Physiology;Cell Survival;Cells;Cellular Stress;Cellular Structures;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;Data;deprivation;Development;developmental disease;Disease;EIF-2alpha;Embryo;Embryonic Development;embryonic stem cell;Endothelial Cells;endothelial stem cell;Endothelium;Engineering;Epiblast;experimental study;F-Actin;Functional disorder;Genes;Genetic Markers;Human;human induced pluripotent stem cells;Immunofluorescence Immunologic;induced pluripotent stem cell;induced pluripotent stem cell technology;insight;Intercellular Junctions;Knock-out;Mediating;Mesoderm;Messenger RNA;Morphology;mRNA Translation;Mus;novel;Nutrient;Pathogenesis;Pathway interactions;PECAM1 gene;Phosphorylation;Play;pluripotency;pluripotency factor;preimplantation;Proliferating;Protein Biosynthesis;Protein-Serine-Threonine Kinases;Proteins;Proteome;Research;response;Ribosomes;Role;Self Assessment;self-renewal;sensor;Stains;Starvation;stem cell self renewal;stem cells;Stimulus;Stress;Techniques;Testing;Time;Transcriptional Regulation;Translating;Translational Regulation;translatome;Tube;Undifferentiated;uptake;Visualization;Western Blotting

PROJECT_TITLE: The role of GCN2 in human induced pluripotent stem cell maintenance, differentiation and endothelial cell function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE Cellular replication requires exquisite spatial control of cell contents, especially genetic information. This project examines new ideas about how certain protein sequences can result in concentration of key cellular components together as a necessary step for successful cell replication. Better understanding of the physical mechanisms of cellular replication will help develop treatments for disorders caused by mutations in these proteins.

PI_NAMEs: RAMIREZ, DOMINIQUE  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: alpha helix;Amino Acid Sequence;Attention;Automobile Driving;Binding;Biogenesis;Bioinformatics;Biological;Biophysical Process;biophysical techniques;Biophysics;career;Cell division;Cells;Centrosome;Characteristics;Chemicals;Chromosome Segregation;ciliopathy;Circular Dichroism;Coiled-Coil Domain;Complex;Computing Methodologies;Cytosol;Data;design verification;Development;Disease;Down's Syndrome;Dwarfism;Ensure;experimental study;Fellowship;Functional disorder;genetic information;Human;Human Genome;improved;In Vitro;Inosine Diphosphate;Knowledge;Length;Liquid substance;macromolecule;Maintenance;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;membrane biogenesis;Membrane Lipids;Mentors;Modeling;molecular modeling;Monitor;Mutate;Mutation;Nerve Degeneration;Organelles;Outcome;overexpression;pericentrin;Phase;Positioning Attribute;Process;Protein Family;Protein Fragment;protein protein interaction;Protein Region;Protein Truncation;Proteins;recruit;Research;Role;Scientist;screening;segregation;self assembly;simulation;Source;Structure;synthetic protein;System;Techniques;Testing;tool;trafficking;Training;Visualization;Vocational Guidance;Work

PROJECT_TITLE: Understanding the role of coiled-coil domains in regulating liquid-liquid phase separation of protein assemblies in cell division

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) Cachexia involves the involuntary loss of weight due to the combination of reduced food intake and hyperactive catabolism in skeletal muscle and adipose tissue and is highly prevalent in solid malignancies. Despite almost 50% of cancer patients experiencing features of cachexia and its association with increased morbidities and mortality, there are currently no approved treatments for cancer-associated cachexia. This proposal will identify how tumor genetics, an intact immune system, and diet promote cachexia, providing key insight into the mechanisms that drive cachexia to be exploited by future therapeutics.

PI_NAMEs: CROSS, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 5'-AMP-activated protein kinase;Ablation;Adipose tissue;Animal Feed;Animal Model;Anorexia;anorexic;Antibodies;Area;Automobile Driving;base editing;Binding;biological adaptation to stress;biomarker identification;Body mass index;Body System;Body Weight decreased;Brain Stem;Cachexia;Cancer Cachexia;Cancer Patient;carcinogenesis;Catabolism;cell behavior;Characteristics;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus;Consumption;CRISPR/Cas technology;cytokine;Data;Development;Diagnosis;Diet;Dietary Factors;Dietary Fats;Dietary Intervention;Disease;disease heterogeneity;Drug Targeting;Eating;effective intervention;effective therapy;energy balance;experience;Fatty acid glycerol esters;feeding;Functional disorder;Functional impairment;Future;GDF15 gene;gene therapy;Genetic;Genetic Heterogeneity;Genetically Engineered Mouse;High Fat Diet;Homeostasis;Human Cell Line;human disease;Hyperactivity;Immune system;in vivo Model;Inflammation;Inflammation Mediators;Inflammatory;innovation;insight;Intake;Intervention;ketogenic diet;Lead;Lipids;Liver;loss of function;loss of function mutation;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolism;Metabolite Interaction;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Mouse Cell Line;Mus;Muscle;muscle form;mutant;Mutation;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;Nonesterified Fatty Acids;novel;novel therapeutic intervention;Nutritional;Nutritional Support;Obesity;Organ;Patients;Phosphotransferases;Physiological;Physiology;Play;Pre-Clinical Model;prevent;Process;Production;public health relevance;Quality of life;receptor;reduced food intake;Resolution;response;Role;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Sodium Chloride;Solid;Stimulus;STK11 gene;Symptoms;Syndrome;Systemic disease;Testing;Therapeutic;Thinness;Treatment-Related Cancer;tumor;Tumor Burden;tumor microenvironment;Tumor-Derived;Weight;Work

PROJECT_TITLE: Investigating cancer-associated cachexia in genetic subtypes of lung cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Endocannabinoid System Research;Mental Health;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Therapeutic Cannabinoid Research

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative To advance research on non-opioid analgesic therapeutics, this project will investigate the non-intoxicating, FDA-approved cannabis terpene, myrcene, and its effects on pain hypersensitivity and negative affective states associated with a mouse model of chronic neuropathic pain. This proposal will determine the extent myrcene engages the endocannabinoid system in areas of the brain implicated in the descending modulation of pain. The information gained from this study will clarify the relationship between terpenes and endocannabinoids and their role in chronic pain.

PI_NAMEs: RICE, MYRA JANE (contact)

PROGRAM_OFFICER_NAME: BELFER, INNA

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Adult;Adverse event;Affect;Affective;Analgesics;Animals;antagonist;Anti-Inflammatory Agents;antinociception;Applications Grants;Area;Attenuated;awake;Award;Behavior;Behavior assessment;behavior test;Behavioral;Binding;Brain;Brain region;cannabinoid receptor;Cannabinoids;Cannabis;career;CB2 receptor antagonist;Chemicals;Chemistry;chronic constriction injury;chronic neuropathic pain;chronic pain;chronic pain patient;Clinical;CNR1 gene;collaborative environment;Complex;conditioned place preference;constriction;Coupled;Data;Data Analyses;Detection;disadvantaged background;Endocannabinoids;endogenous cannabinoid system;Environment;experience;extracellular;fatty acid amide hydrolase;FDA approved;Fiber;Gene Modified;genetic approach;Goals;Human;Human Resources;Hyperalgesia;Hypersensitivity;Immunohistochemistry;in vivo;inhibitor;Injections;Injury;Institution;International;knock-down;Laboratories;Laboratory Research;Life;MAGL inhibitor;Manuscripts;marijuana use;Measures;mechanical stimulus;Mechanics;Medical Marijuana;meetings;Mental disorders;Mentors;midbrain central gray substance;Modeling;Monoacylglycerol Lipases;Motivation;mouse model;Mus;Natural Increases;negative affect;Negative Reinforcements;Nociception;non-opioid analgesic;novel;novel therapeutics;Odors;Operative Surgical Procedures;Opioid;Opioid Analgesics;opioid misuse;Oral;Outcome;Pain;pain model;pain patient;pain relief;pain symptom;Patients;Performance at work;Peripheral nerve injury;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Photometry;physical conditioning;phytocannabinoid;Plants;Population;posters;pre-clinical;prescription opioid;Productivity;Property;Psyche structure;receptor;Reporting;Research;Research Personnel;Resources;Rodent;Role;Scientist;sensor;Sensory;side effect;Signal Transduction;skills;supportive environment;Sushi Domain;Techniques;Terpenes;Testing;Tetrahydrocannabinol;Therapeutic;therapeutically effective;Training;transmission process;Viral;Viral Packaging;Withdrawal;Work;Writing

PROJECT_TITLE: Modulation of pain hypersensitivity by terpenes via endocannabinoid release in descending circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (04)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it investigates prevalence of, root causes of, and an intervention to address an under-studied medical barrier to family planning use: when providers deny a preferred method of family planning with an illegitimate or inappropriate medical rationale. Preventing the application of inappropriate medical contraindications would improve person-centeredness of family planning services and has the potential to reduce contraceptive discontinuation due to dissatisfaction with a non- preferred family planning method. This project leverages innovative and rigorous data from an NIH-funded parent study - including mystery client observations and a cluster randomized design - and implements a mixed-methods approach to address a challenging, impactful, and understudied barrier to contraceptive access in the Global South.

PI_NAMEs: CHUNG, STEPHANIE ROSLYN-ISABELLE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accountability;Address;African;Age;Area;arm;Caring;Child Mortality;Client;cluster randomized design;Communities;community empowerment;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;Country;Cross-Sectional Studies;Data;Data Collection;Data Sources;data standards;Decision Making;Demographic and Health Surveys;demographics;Development;effective intervention;Eligibility Determination;evidence base;experience;experimental study;Family Planning;Foundations;Frequencies;Funding;Goals;High Prevalence;improved;innovation;Intervention;Interview;Kenya;Knowledge;Marital Status;Maternal Mortality;Measures;Medical;Methodology;Methods;Modeling;Monitor;National Institute of Child Health and Human Development;Nature;neglect;Parents;parity;Patient-Centered Care;patient-clinician communication;Patients;Performance;person centered;Population;post intervention;preference;Pregnancy;Prevalence;prevent;Process;Provider;provider communication;Public Facilities;Public Health;Public Sector;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reporting;reproductive;Reproductive Health;Research;Research Personnel;Resource-limited setting;response;Risk;Sampling;satisfaction;service delivery;skills;Social Accountability;Standardization;Structure;Survey Methodology;Surveys;Testing;Time;Training;unintended pregnancy;United States National Institutes of Health;Unwanted pregnancy;Visit;Weight;Woman

PROJECT_TITLE: Non-Preferred Contraceptive Method Use in Low-Resourced Settings: Exploring Inappropriate Medical Contraindications and Person-Centered Care

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The Binding Problem asks how the diverse contents of awareness are unified, a cortical process that is fundamental to understanding healthy and disrupted cognition in humans. This study will test if bursts of high- frequency cortical oscillations (i.e., ‘ripples’) possess the properties crucial to a possible role in binding. If successful, this work will lay the foundation to study neural binding in the human cortex, thereby facilitating the investigation of how information processing is disrupted in many form of neuropsychiatric disease.

PI_NAMEs: VERZHBINSKY, ILYA ALEXEY (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Accounting;Anatomy;Area;Awareness;Behavior;Behavioral;Binding;Brain;Cervical spinal cord injury;Cognition;cognitive function;cognitive performance;Collection;Color;Communication;Data;Data Set;Dependence;design;Detection;Disparate;Electrophysiology (science);Elements;Epilepsy;executive function;experience;finger movement;Fingers;Fire - disasters;Foundations;Frequencies;Functional disorder;Hand;High Frequency Oscillation;Hippocampus;Hour;Human;Impaired cognition;indexing;information processing;Instruction;Interneurons;Intractable Epilepsy;Investigation;Left;Linear Models;Location;Measures;memory consolidation;memory recall;Microelectrodes;Modeling;Motion;Movement;multimodality;neural;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;non rapid eye movement;novel;Patients;Pattern;Perception;Performance;Phase;Population;Process;Property;Role;Schizophrenia;Shapes;Site;Sleep;Stereotyping;Stimulus;Superior temporal gyrus;Technology;Testing;Texture;Thumb structure;Utah;Visual;Work

PROJECT_TITLE: Human Cortical Ripples as a Mechanism for Neural Binding

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Nutrition;Prevention

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Retinoids, the active forms of vitamin A, have significant impacts on human health, influencing vision, immunity, metabolism, embryonic development, reproduction, and cell differentiation. They also serve as crucial therapeutics for cancers, skin and visual diseases, and are promising therapeutic approaches for treating neurological, and metabolic disorders. The primary aim of the 7th International Conference on Retinoids FASEB SRC is to facilitate scientific exchange and collaborations in fundamental research and clinical applications of retinoids for disease prevention and treatment, while offering training opportunities for newcomers and early- stage investigators in the field.

PI_NAMEs: NAGY, LASZLO  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Affect;American;analytical method;analytical tool;Animal Model;anti-cancer research;Area;Award;Back;base;Basic Science;bench to bedside;Biochemical;Biochemistry;Biological;Biological Assay;Biology;cancer therapy;Cardiovascular Diseases;career;Career Choice;career development;Carotenoids;Cell Differentiation process;Chemistry;Child Health;Clinical;clinical application;Collaborations;Development;dietary;Dietary Intervention;Discipline;Disease;disorder prevention;Embryonic Development;Ensure;Environmental Risk Factor;Enzymes;equity, diversity, and inclusion;Eye;fundamental research;Funding;gastrointestinal;Genetic;Genomic approach;Goals;Health;Human;Image;Immunity;Immunology;Individual;individual response;Infection;International;Investigation;kinetic model;Knowledge;Learning;Malignant Neoplasms;Mass Spectrum Analysis;meetings;Mentors;Metabolic;Metabolic Diseases;Metabolism;Mission;Modeling;Molecular;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuronal Plasticity;novel;Nutritional;Nutritional Science;Oral;pharmacologic;Physiological;Postdoctoral Fellow;posters;prediction algorithm;Prevention;Process;Provitamin A Carotenoid;Regenerative pathway;Regulation;Reporter;Reproduction;Request for Applications;Research;Research Methodology;Research Personnel;response;Retinoids;Role;Schedule;Science;Scientist;Signal Transduction;Skin;skin disorder;Societies;stem cell biology;structural biology;symposium;Therapeutic;tool;Training;training opportunity;Travel;Underrepresented Populations;United States National Institutes of Health;uptake;Vision;Vision Disorders;Vision research;Visual;Visual System;Vitamin A;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

PHR: Project Narrative This proposal seeks to illuminate the cardiogenic cellular hierarchy and the gene regulatory networks that determine the origins and fates of Juxta-Cardiac Field (JCF) cardiovascular progenitor cells during heart development. Results from these studies will yield new insights into how disrupted cardiovascular regulatory networks lead to congenital heart disease and how they may be modified to develop treatments to improve patient outcome.

PI_NAMEs: CHI, NEIL C (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Address;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cell Lineage;cell type;Cells;Chromatin;Circulation;congenital heart abnormality;Data Analyses;Development;Embryo;Embryoid bodies;Endothelium;Epicardium;Etiology;Fibroblasts;Fluorescence;gastrulation;gene conservation;Gene Expression Profile;gene regulatory network;Genetic;Genetic Transcription;Heart;heart function;Human;human pluripotent stem cell;improved;In Situ;insight;Label;Lateral;Lead;Left ventricular structure;Maps;Mesothelium;mouse model;multidisciplinary;multiple omics;Mus;Patient-Focused Outcomes;progenitor;programs;Protocols documentation;RNA;Smooth Muscle Myocytes;Source;spatiotemporal;stem cell differentiation;stem cell population;stem cells;Structure;System;Systems Biology;Tamoxifen;transcription factor;transcriptomics;Transgenic Organisms

PROJECT_TITLE: Mechanisms of Juxta-Cardiac Field Progenitors

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: LINCOLN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PHR: Project Narrative Sexual violence (SV), trauma symptoms, alcohol use, and intimate partner violence (IPV) are all major public health issues that disproportionately affect bisexual women (BiW). This project tests a model in which receipt of intimate partners’ negative reactions in response to SV disclosure is associated with increased trauma symptoms, which exacerbate alcohol use that, in turn, heightens risk for IPV victimization. The role of minority stress in exacerbating trauma symptoms, alcohol use, and, ultimately, IPV victimization is examined.

PI_NAMEs: BOGEN, KATHERINE WELA (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Adult;Adverse effects;Affect;Alcohol abuse;Alcohol consumption;Alcohols;assault;Attitude;Belief;Bisexual;career;Clinical;Cognition;Communities;Complex;coping;Couples;Development;Disclosure;Discrimination;Distress;drinking;Educational Curriculum;effective intervention;Emotional;emotional abuse;experience;Functional disorder;Gays;hazardous drinking;Health;help-seeking behavior;Heterosexuals;Intervention;intimate partner violence;Lesbian;Light;Link;Literature;London;Longitudinal Surveys;Mediating;Mediation;Mental Health;minority stress;Modeling;Moods;Negative Reinforcements;Outcome;Patient Self-Report;peer;physical abuse;physical conditioning;Play;Positioning Attribute;post-traumatic stress;post-traumatic symptoms;Process;Proliferating;psychologic;Public Health;Questionnaires;Reaction;Recovery;Reporting;Research;Resources;response;revictimization;Risk;Risk Factors;Role;Sampling;Scientist;Sexual abuse;Sexual Health;sexual minority;sexual violence;Sexuality;social;Stereotyping;Survivors;Symptoms;Taxes;Testing;Time;Training;Trauma recovery;trauma symptom;Validation;Violence;violence exposure;violence victimization;Woman;Work

PROJECT_TITLE: Post-Traumatic Stress and Alcohol Use as Mechanisms Explaining IPV Among Bisexual Women Who Disclose Sexual Violence to Partners: Examining Minority Stress as a Moderator

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Metabolic dysfunction-associated steatotic liver disease (MASLD) is a rapidly growing epidemic with no FDA approved treatments and is a significant global health and economic burden. Mitochondria play an essential role in restricting progression of steatotic liver disease to steatohepatitis (MASH) by acting as a relief valve for excess lipid. In this proposal, I will identify the role and regulation of SLC25a25, a mitochondrial solute carrier, in the onset and progression of MASH with the goal of identifying a novel therapeutic target.

PI_NAMEs: HEINTZ, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: acute liver injury;Adenine Nucleotides;Adenosine Monophosphate;Adenosine Triphosphate;adenylate;Adult;Affect;analog;Animal Model;Bioenergetics;Biological Process;burden of illness;Calcium;Cell Respiration;chronic liver disease;Cirrhosis;clinical care;Coupled;Cross-Sectional Studies;Cytoplasm;Data;Deposition;Development;Disease;Disease Progression;Economic Burden;effective therapy;Enzymes;Epidemic;Family;fatty acid oxidation;FDA approved;Fibrosis;first-in-human;flexibility;Functional impairment;Future;global health;Goals;Health;Hepatic;Hepatocyte;Homeostasis;Hour;Human;Impairment;improved;Individual;Inflammation;Injury;Inner mitochondrial membrane;innovation;inorganic phosphate;Insulin Resistance;intrahepatic;Investigation;Ions;Lipids;Liver;Liver diseases;liver function;liver injury;Liver Mitochondria;loss of function;Maintenance;Malignant neoplasm of liver;Mediating;Mediator;member;Metabolic;Metabolic dysfunction;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nuclear;obese patients;Obesity Epidemic;Organ Transplantation;Organelles;oxidation;Oxidative Stress;Patient-Focused Outcomes;Patients;Pharmacotherapy;Physiological;Play;Population;Prevalence;prevent;Process;Production;Provider;Regulation;respiratory;Role;Sampling;Severities;simple steatosis;solute;Steatohepatitis;Stress;Structure;targeted treatment;Testing;therapy development;Toxic effect;Transgenic Organisms

PROJECT_TITLE: Hepatic SLC25a25 in Steatotic Liver Disease Progression

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]