NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Over 1 million Americans have Familial Hypercholesterolemia (FH) and 90% of them are undiagnosed and untreated, with substantial disparities in Black and African American people, Asian people, and women. Cascade screening is an evidence-based practice that includes contacting and screening biological relatives of index cases that is cost-effective and has the potential to save lives. The proposed work has the potential to radically impact public health by testing which patient-facing implementation strategies, designed with key stakeholders, are most effective in increasing cascade screening in partnership with the FH Foundation. This clinical trial will take place in Penn Medicine and will use principles from behavioral economics to increase cascade screening while also gathering information about effectiveness and mechanisms in order to inform large-scale equitable implementation efforts nationally to save the lives of all Americans with FH.

PI_NAMEs: BEIDAS, RINAD SARY (contact);RADER, DANIEL JAMES;VOLPP, KEVIN G

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;advocacy organizations;African American;African American population;American;arm;Asian population;Atherosclerosis;Authorization documentation;automated text message;behavioral economics;Biological;Black American;Black race;Cardiac;cardiovascular risk factor;cascade genetic testing;Cessation of life;Clinical Trials;Consolidated Framework for Implementation Research;cost;cost effective;Country;design;Diabetes Mellitus;Diagnosis;Disparity;Early identification;Effectiveness;effectiveness-implementation RCT;Equity;ethnic minority;Ethnic Origin;Event;evidence based guidelines;Evidence based practice;experience;Familial Hypercholesterolemia;Family member;follow-up;Foundations;Future;Gender;Genetic Diseases;Genomics;health equity;Health system;Hybrids;Hypertension;implementation barriers;implementation efforts;implementation science;implementation strategy;improved;Incidence;Income;indexing;Individual;information gathering;Inherited;International;Interview;LDL Cholesterol Lipoproteins;Lipids;Low income;Measures;Mediating;Medical;Medicine;men;Methods;Morbidity - disease rate;National Heart, Lung, and Blood Institute;Notification;Other Genetics;outreach;Patients;Persons;Phase;Pilot Projects;Play;Population;Populations at Risk;premature;proband;Public Health;Race;racial minority;Randomized, Controlled Trials;Recommendation;Research;Risk;Sampling;screening;screening program;secondary endpoint;Testing;treatment as usual;Trust;uptake;willingness;Woman;women's treatment;Work

PROJECT_TITLE: Leveraging behavioral economics to equitably implement cascade screening in individuals with familial hypercholesterolemia in partnership with the FH Foundation


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Veterans with leg amputations have limited footwear options because their artificial feet do not change shapes for different shoes. Studies have shown that women with amputations receive more frequent prosthetics care than men, but are less satisfied with the fit, comfort, and appearance of their prostheses. Our previous research indicates that women Veterans would like to be able to wear a broader variety of footwear, and those who perceive more footwear limitations tend to have poorer body image and community participation. A new prosthesis designed by our group allows Veterans with amputations to use their footwear of choice using 3D-printed artificial feet with a single ankle. Our novel prosthesis will be tested in this project with women Veterans with amputations to determine the impact of improving footwear options on body image and community participation.

PI_NAMEs: HANSEN, ANDREW H. (contact)

PROJECT_TITLE: Impact of Improving Footwear Options for Women Veterans with Amputations

STUDY_SECTION: RRDE

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRDE]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: SIMPSON, CHRISTOPHER D (contact)

PROJECT_TERMS: analytical method;Assessment tool;Automation;Biological;Biological Assay;Biological Markers;Chemical Agents;Chemicals;Collection;Communities;Complex Mixtures;Consultations;Core Facility;cost;Data;Data Analyses;data management;Development;Disease;Environment;Environmental Health;Epigenetic Process;Exposure to;Genomics;Geographic Information Systems;Goals;Health;Health Policy;health science research;improved;innovation;instrumentation;Intervention;Leadership;Mass Spectrum Analysis;Measurement;Measures;metabolomics;Methods;Monitor;novel;particle;personal exposure monitor;population based;Proteomics;Public Health;Research;Research Personnel;Sampling;Science;sensor;Services;System;Technology;tool;Universities;Visualization software;volatile organic compound;Washington

PROJECT_TITLE: Exposure Assessment, Biomarkers, and Environmental Sensing Facility Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Although the nasal mucosa is arguably the most frequently infected tissue in mammals, the cellular immune landscape that pathogens encounter upon entry into the nasal mucosa remains largely unexplored. Preliminary results for this project suggest that the nasal mucosa at steady state harbors a large population of extravascular neutrophils that are composed of three subsets which each display unique phenotypic and molecular characteristics. Based on extensive preliminary data, this project will test the hypothesis that beyond phenotypic diversity, each nasal neutrophil subset has a distinct origin, accesses the NM by discrete mechanisms, and exerts specialized functions in host defense and tissue homeostasis.

PI_NAMEs: VON ANDRIAN, ULRICH H (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: adaptive immune response;Address;Adhesions;Adoptive Transfer;Affect;Air;Anatomy;Antigen-Presenting Cells;Antigens;Bacterial Infections;Behavior;Blood;Blood Vessels;Bone Marrow;Brain;Candida albicans;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;Cephalic;Characteristics;Chlamydia muridarum;Clinical;Complex;conditioning;Data;Disease;Environment;experimental study;Exposure to;extracellular;Flow Cytometry;Gene Expression Profile;Germ-Free;Goals;Health;Homeostasis;Homing;Host Defense;Human;Hypersensitivity;Immune;Immune response;Immunobiology;Immunologic Surveillance;Immunologics;improved;Infection;Inhalation;Innate Immune Response;intravital microscopy;ITGAX gene;Leukocytes;Mammals;microbial;microbiome;Microcirculation;microorganism interaction;Microscopy;Modeling;Molecular;Morphology;Mucous Membrane;Mus;Mycoses;Nasal cavity;neutrophil;Neutrophil Infiltration;Nose;novel;opportunistic pathogen;Organ;Parabiosis;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Pathologic;Phenotype;Physiological;Play;Population;Property;recruit;respiratory pathogen;Respiratory Tract Infections;Role;Sensory;single-cell RNA sequencing;source localization;stem cell migration;Stimulus;Streptococcus pneumoniae;Structure of mucous membrane of nose;Submucosa;Surface;Surveys;T cell response;Testing;Tissues;transcriptome sequencing;transcriptomics;Upper respiratory tract;Vaccines;Vertebrates;Work

PROJECT_TITLE: Neutrophil Dynamics in Nasal Mucosa

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative (PUBLIC HEALTH RELEVANCE) Acute intestinal injury is a major limiting factor in the recovery of radiation victims and some cancer patients. There is currently no FDA-approved treatment. The proposed work will provide novel insights on epithelium- immune interactions critical for intestinal recovery, and help establish temporal STING/Type 1 interferons as novel and normal tissue selective therapeutic targets to treat radiation-induced acute intestinal injury.

PI_NAMEs: YU, JIAN  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: 3-Dimensional;Abdomen;Acute;Adult;ATAC-seq;Bone Marrow;Cancer Patient;Cell Death;cell injury;Cells;Cessation of life;chemokine;Chemotherapy and/or radiation;Chronic;Coupled;Data;Dissection;DNA Damage;Dose;Dose Limiting;dysbiosis;efficacy evaluation;Enteritis;epigenomics;Epithelium;Excision;FDA approved;FRAP1 gene;Functional disorder;Gastrointestinal Injury;Genetically Engineered Mouse;Health;Hour;Human;Image;Immune;Immune signaling;Immune Targeting;Impairment;improved;in vivo;Inflammation;injury recovery;insight;Interferons;interleukin-22;intestinal barrier;intestinal epithelium;intestinal injury;Intestines;irradiation;Knowledge;LGR5 gene;Longevity;Marrow;Mediating;Mitotic;Modeling;Molecular Analysis;mouse model;Mucosal Immunity;Mus;Mutagens;Natural regeneration;Normal tissue morphology;novel;Organoids;Paneth Cells;Pathway interactions;PIK3CG gene;Play;preservation;Prevention;Production;Proliferating;public health relevance;Quality of life;Radiation;Radiation Injuries;radiation recovery;receptor;Recovery;repaired;response;Role;Signal Transduction;stem cell division;stem cell niche;stem cell self renewal;stem cells;Stimulator of Interferon Genes;Survivors;systemic inflammatory response;Testing;Therapeutic;therapeutic target;Tissues;tool;TP53 gene;transcriptome sequencing;transcriptomics;Whole-Body Irradiation;Work

PROJECT_TITLE: STING-dependent Intestinal Regeneration upon Radiation Injury

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Lung;Patient Safety;Sleep Research

ORG_CITY: CINCINNATI

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE Continuous Positive Airway Pressure (CPAP) is broadly considered first-line therapy for Obstructive Sleep Apnea. Non-compliance with the therapy is often due to the discomfort associated with tight-fitting masks. The current project will develop new technology, VortexPAP, which doesn't require a tightly sealed interface between the mask and the patient's face.

PI_NAMEs: OREN, LIRAN  (contact)

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TERMS: adverse outcome;Aerospace Engineering;Affect;Air Movements;airway obstruction;base;Breathing;Cannulas;Cardiovascular Diseases;Chronic;Clinical effectiveness;clinical efficacy;Collaborations;commercialization;Computers;Continuous Positive Airway Pressure;Data;data acquisition;design;Development;Devices;Dimensions;Ensure;Equipment;Evaluation;Face;Feedback;Goals;Habits;Human;Image;Individual;Industry;laptop;manufacture;Marketing;Masks;Muscle relaxation phase;new technology;non-compliance;Nose;Obstruction;Obstructive Sleep Apnea;Patient Compliance;Patients;Penetration;Pharyngeal structure;pharynx muscle;Phenotype;Physiologic pulse;Physiological;Population;Positioning Attribute;positive airway pressure;preference;pressure;prevent;product development;Production;programs;Property;prototype;pulmonary function;Reapplication;Recommendation;Risk;seal;Security;Sleep;Sleep Apnea Syndromes;soft tissue;stem;Structure;System;Technology;Testing;therapy adherence;Treatment Failure;Universities;Work

PROJECT_TITLE: Using vortical airflow to pressurize the upper airway without a tight seal during CPAP therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: ERRETT, NICOLE ANN (contact)

PROJECT_TERMS: Affect;Air;air monitoring;Applications Grants;Area;behavior change;Collaborations;Communication;Communication Tools;Communities;community collaboration;Community Developments;community engaged research;community engagement;Community Health;community involvement;Community of Practice;community organizations;community partners;community science;Consultations;design;digital;Disasters;Disease;Effectiveness;Environment;Environmental Exposure;Environmental Health;Environmental Impact;Event;experience;Face;follow-up;Fostering;Genomics;Goals;Grant;Health;health literacy;Health Professional;Health Promotion;health science research;improved;Individual;Inhalation;Inhalation Exposure;innovation;Intervention;Lead;Leadership;Low income;Measures;meetings;member;Mission;Outcome;Pilot Projects;podcast;Policies;Policy Maker;programs;Public Health;Public Health Practice;Research;Research Personnel;Research Proposals;Resource Development;Resources;response;Rural Community;Science;skills;Smoke;teacher;tool;Training;Translating;translational engagement;Translational Research;Tribes;Universities;Urban Community;vaping;Vision;Washington;Wildfire;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Defects in gametogenesis represent a major cause of human birth defects, miscarriage and  infertility. Because ethical and technical issues limit the mechanistic depth of data obtained from  human studies, model systems are invaluable. This application will delineate essential conserved  mechanisms by which intercellular signaling and translational regulation regulate developmental   programs needed for reproduction in the nematode Caenorhabditis elegans.

PI_NAMEs: GREENSTEIN, DAVID IRWIN (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Affect;Area;Biological Models;Caenorhabditis elegans;cell behavior;Cell Cycle;Cell Nucleus;Cells;Cellular biology;Complex;Congenital Abnormality;Data;Defect;Development;Developmental Biology;Disease;Embryo;Ensure;Ethics;Event;Fertilization;fundamental research;Gametogenesis;Gap Junctions;Genetic;Genetic Models;Genetic Transcription;Germ Cells;Germ Lines;germline stem cells;Goals;Health;Heart;Human;human disease;Infertility;insight;intercellular communication;Investigation;Knowledge;Laboratory Organism;mechanical force;mechanotransduction;Mediating;Meiosis;Modernization;Molecular;Nature;Nematoda;neuronal cell body;novel therapeutic intervention;Nuclear;Nuclear Envelope;Nutritional;Oocytes;Oogenesis;posttranscriptional;Process;programs;Proteins;Regulation;Reproduction;reproductive function;Research;Research Proposals;Role;Series;Signal Transduction;Spontaneous abortion;System;Technology;Testing;Translational Regulation;Translations;Tube;Vision;Work

PROJECT_TITLE: The C. elegans Germline: A Test Tube for Cell and Developmental Biology

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


PI_NAMEs: SATHYANARAYANA, SHEELA  (contact)

PROJECT_TERMS: Applications Grants;Area;Biological Models;career;career development;Cells;Clinical Investigator;community engagement;Community Outreach;Creativeness;Data;design;Disasters;Disease;Environment;Environmental Exposure;Environmental Health;Epigenetic Process;epigenetic variation;Faculty;Fostering;Funding;Future;gene environment interaction;Genetic Variation;Genomics;Goals;Grant;health science research;Human Genetics;Incentives;innovation;Interdisciplinary Study;Investigation;Investments;member;microphysiology system;Mission;molecular phenotype;multidisciplinary;National Institute of Environmental Health Sciences;novel;Pilot Projects;programs;Publications;Research;Research Activity;Research Personnel;Research Project Grants;response;Rewards;Role;Scientist;success;tool;Toxicology;transcriptomics;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Pilot Project Program


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Proteins are long chains that must fold into specific three-dimensional structures to carry out their functions, which include digesting nutrients, making muscles contract, and enabling communication of neurons in the brain, among many others. Like long strands of yarn quickly become entangled if not organized into balls, proteins that fail to fold into their functional structures promptly tend to clump together into aggregates, which can be detrimental to cellular and organismal function and is associated with neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Our mechanistic studies will clarify how proteins fold into their functional structures and avoid aggregation, providing fundamental insights into disease mechanisms.

PI_NAMEs: HILSER, VINCENT J. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: aging related disease;Alzheimer's Disease;attenuation;Bacteria;Binding;Biological;Biology;Biophysics;Brain;Cell Physiology;Cells;Codon Nucleotides;Communication;Complex;Contracts;Coupled;Cultured Cells;Cytosol;cytotoxic;defined contribution;Detection;detection method;Disease;Ensure;Eukaryota;Event;experimental study;Future;Geometry;Goals;In Vitro;in vivo;Individual;insight;laser tweezer;Length;Link;Malignant Neoplasms;Measurement;Measures;mechanical force;Mechanics;Molecular;Molecular Chaperones;Muscle;Neurodegenerative Disorders;Neurons;novel therapeutic intervention;Nutrient;optic tweezer;Outcome;overexpression;Parkinson Disease;Pathway interactions;Peptides;Peptidyltransferase;polypeptide;Process;Productivity;Property;protein aggregation;Protein Biosynthesis;protein folding;protein misfolding;Proteins;Proteome;proteostasis;reconstitution;Regulation;Resolution;ribosome profiling;Ribosomes;Role;Shapes;single molecule;Structure;Tertiary Protein Structure;three dimensional structure;Translations;Variant;Work;Yeasts

PROJECT_TITLE: Folding and Chaperone Interactions of Multi-domain Proteins

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative  This proposal investigates the therapeutic potential of using hypothermia to restore activity of temperature-sensitive p53 mutants in mouse tumor models. The p53 tumor suppressor is frequently inactivated by mutations in cancer. Currently no approved drugs are available for restoring the activity of mutant p53. Although p53 missense mutants are inactive at 37°C, ~14% are temperature-sensitive (ts) that regain activity at 32°C. The p53 ts mutants represent a unique class that may be activated by mild hypothermia, which is currently standard of care for post- cardiac arrest patients. We have established conditions for inducing controlled hypothermia in mice. Preliminary experiments demonstrated the ability of hypothermia to induce regression and stable remission of tumors expressing ts mutant p53. We will use this system to further investigate conditions that can improve the efficacy of ts p53 targeting and achieving long-term remission. We will also test the effect the hypothermia against clinically-relevant patient-derived xenograft models (PDX) expressing ts mutant p53, and against spontaneous tumors developed in a mutant mouse with germline ts p53 mutation.

PI_NAMEs: CHEN, JIANDONG  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Apoptosis;Binding;Biological Assay;Brain;Bypass;Cancer Patient;cancer therapy;Categories;Cell Cycle;Cell Cycle Arrest;Cell Death Induction;chemotherapy;Clinical;clinical translation;clinically relevant;CRISPR/Cas technology;Databases;deep sequencing;Disease remission;DNA Binding;DNA Binding Domain;DNA Sequence;Drug Targeting;Energy Metabolism;experimental study;Frequencies;functional status;Genes;Genetic Transcription;Genetically Engineered Mouse;Germ Lines;Heart Arrest;Human;Immunocompetent;improved;in vivo;Individual;induced hypothermia;Induction of Apoptosis;Libraries;Lung Neoplasms;Lymphoma;Malignant Neoplasms;MDM2 gene;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;natural hypothermia;neglect;neoplastic cell;novel strategies;pancreatic neoplasm;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;pharmacologic;Point Mutation;prevent;Procedures;Refractory;Relapse;response;senescence;Solid Neoplasm;standard of care;Structural defect;Surface;System;targeted treatment;Temperature;temperature sensitive mutant;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;Thermogenesis;TP53 gene;translational potential;Treatment Efficacy;tumor;Tumor Suppressor Proteins;tumor xenograft;Variant;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Anti-tumor potential of temperature-sensitive p53 mutants

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Nutrition;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project narrative The goal of this project is to carry out large scale multi-omics experiments and live imaging of cellular metabolic state to characterize the role of metabolism in the regulation of gene expression, cell fate and patterning during paraxial mesoderm development. This knowledge is expected to impact our understanding of cancer and congenital malformations of the spine.

PI_NAMEs: POURQUIE, OLIVIER  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Acetylation;Adipose tissue;aerobic glycolysis;beta catenin;cancer cell;Cell Differentiation process;cell fate specification;Cells;Characteristics;Chick Embryo;Chickens;Complex;Congenital Abnormality;Congenital Scoliosis;Connective Tissue;Defect;Development;differentiation in vitro;differentiation protocol;directed differentiation;Embryo;embryo cell;embryonic stem cell;Energy Metabolism;Enzymes;epigenomics;Exhibits;experimental study;extracellular;Funding;Gene Expression Regulation;Global Change;Glycolysis;Goals;Human;Human Development;human induced pluripotent stem cells;Image;In Vitro;in vivo;induced pluripotent stem cell;Knowledge;Lead;Link;live cell imaging;Longevity;malformation;Malignant Neoplasms;Mammals;Mediating;Mesoderm;Mesoderm Cell;Metabolic;Metabolic Pathway;Metabolism;metabolomics;method development;Mitochondria;Molecular;mouse development;Mouse Embryonic Stem Cells;multiple omics;Mus;Musculoskeletal;Paraxial Mesoderm;Pattern;pH gradient;Physiological;Play;Post-Translational Protein Processing;Primitive Streaks;Process;Production;progenitor;Property;Protein Acetylation;protein function;Proteomics;Proxy;Regulation;Reporter;Respiration;Role;Segmentation Clock Pathway;Signal Transduction;single-cell RNA sequencing;Skeletal Muscle;Skeleton;Somites;Species Specificity;Specific qualifier value;Spinal Dysraphism;spine bone structure;stem cell population;stem cells;Structure;System;Tail;Time;Tissues;Transcriptional Regulation;transcriptomics;Vertebral column;Visualization;Warburg Effect;WNT Signaling Pathway;Work

PROJECT_TITLE: Role of Energy Metabolism in Patterning the Vertebrate Musculo-Skeletal Axis

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: NARRATIVE The synthetic sphingolipid SH-BC-893 (893) activates an evolutionarily-conserved growth control pathway that kills cancer cells while sparing normal proliferative cells. This project will establish whether 893’s unique, pleiotropic mechanism of action makes it more robust, and therefore less susceptible to the development of drug resistance, than existing therapies. Whether 893 overcomes resistance to FDA-approved cancer therapies will also be assessed.

PI_NAMEs: EDINGER, AIMEE L (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: access restrictions;Address;analog;androgen deprivation therapy;Androgen Receptor;anti-cancer;anti-PD-1;anti-tumor immune response;Antineoplastic Agents;Binding;Biochemical;Biological Assay;Bone Marrow;cancer cell;Cancer Control;Cancer Patient;cancer therapy;Cell Proliferation;Cell Survival;Cells;Cessation of life;chemoproteomics;chemotherapy;Complex;Cytotoxic Chemotherapy;Data;Dependence;docetaxel;Dose;driver mutation;drug development;Drug Kinetics;Drug resistance;drug resistance development;Drug Sensitization;Epigenetic Process;evidence base;Exhibits;FDA approved;Genetic Heterogeneity;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;immune checkpoint blockade;Immunooncology;Importins;improved;Individual;inhibitor;innovation;intestinal crypt;Isogenic transplantation;Label;Laboratories;Ligands;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Modeling;Mus;Mutation;Natural Compound;neoplastic cell;Normal Cell;novel;novel strategies;novel therapeutic intervention;Nuclear Import;Nuclear Pore;Nutrient;Oncology;Organ;Organoids;Outcome;Pathway interactions;patient subsets;Patients;Performance;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Pore Proteins;Predisposition;pressure;prevent;Proliferating;Property;prostate cancer cell;Prostatic Neoplasms;Protein Isoforms;Protein phosphatase;Publishing;Research;Resistance;Resistance development;response;RNA Splicing;Safety;Signal Pathway;Signal Transduction;Signaling Molecule;single cell sequencing;Solid Neoplasm;Sphingolipids;standard of care;Starvation;Stress;subcutaneous;System;targeted treatment;Testing;Therapeutic;Thinking;Time;Toxic effect;trafficking;transcription factor;tumor;tumor growth;tumor heterogeneity;Tumor Suppressor Proteins;Work

PROJECT_TITLE: A novel strategy to overcome drug resistance in cancer


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The Cancer Biology Training Program provides training in translational cancer research for predoctoral and postdoctoral PhD trainees who will become leaders in cancer investigation leading to major improvements in cancer therapy. The program capitalizes on the depth and quality of cancer research and clinical efforts at Yale, including a significant commitment to therapeutic translation. Seasoned PhD trainers working in close collaboration with clinical mentors will provide rigorous training in fundamental biological principles combined with a focus on cancer scientific and clinical challenges.

PI_NAMEs: GLAZER, PETER M;STERN, DAVID F (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Cancer Biology;Grant;Training

PROJECT_TITLE: Yale Cancer Biology Training Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE The overarching goal is to develop an innovative, end-user informed Delivery of Antiretrovirals via Implantable System for Young children (DAISY). The DAISY platform addresses challenges for antiretroviral treatment regimens in young children (ages 2-5) in the Republic of South Africa by offering long-term delivery of multiple antiretrovirals (for at least 6 months), retrievability during drug delivery, biodegradation, and discretion of use.

PI_NAMEs: COTTRELL, MACKENZIE ;JOHNSON, LEAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 5 year old;Achievement;Address;Adherence;Adolescent;Adverse reactions;Age;analog;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;biodegradable polymer;Biodegradation;Caregivers;Characteristics;Child;Childhood;Clinic Visits;clinical practice;clinical translation;Collaborations;Data;Deoxycytidine;design;Development;Devices;Disease Progression;Dose;drug action;Drug Delivery Systems;Drug Kinetics;drug release kinetics;drug release profile;Effectiveness;emtricitabine;Engineering;Excision;fabrication;Female;Formulation;Future;future implementation;Goals;Health Personnel;Healthcare Systems;HIV;HIV anti-retroviral;HIV Seropositivity;HIV-1;Implant;implant design;improved;In Vitro;in vivo;indicated prevention;industry partner;inhibitor;innovation;Integrase;International;Intervention;Kinetics;Lamivudine;Link;Macaca mulatta;male;manufacturing process;Measures;multidisciplinary;New Zealand;nonhuman primate;North Carolina;Nucleosides;Oral;Oryctolagus cuniculus;Pattern;pediatric human immunodeficiency virus;Pediatrics;Pharmaceutical Preparations;Phase;Population;pre-clinical;preclinical study;preference;Principal Investigator;product development;programs;Property;prototype;Qualitative Methods;Regimen;Research;Research Personnel;RNA-Directed DNA Polymerase;Role;Safety;safety testing;Science;Social Behavior;social stigma;South Africa;Specific qualifier value;subcutaneous;System;Tail;Technology;technology development;Tenofovir;Testing;Time;Treatment Protocols;United States National Institutes of Health;Universities;Viral;Work

PROJECT_TITLE: LA HIV Treatment in Pediatrics


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Pregnancy;Prevention;Stroke;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Acute neurological complications, including intracerebral hemorrhage, cerebral edema, cerebral vasospasm, and ischemic stroke, are a leading cause of postpartum severe maternal morbidity and mortality in individuals with preeclampsia. We propose to apply a novel, non-invasive neuromonitoring approach to the management of BP in postpartum preeclampsia in a single-center, Phase II clinical trial, PROMIS (PROtecting Maternal brains from Injury and Stroke). We will use near-infrared spectroscopy monitoring to calculate personalized limits of cerebral autoregulation in 20 individuals with postpartum preeclampsia with severe features (Aim 1); and pilot the use of autoregulation-guided BP goals for treatment of postpartum preeclampsia with severe features in an additional 20 individuals with (Aim 2).

PI_NAMEs: MILLER, ELIZA C (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accounting;Acute;Acute Brain Injuries;Address;Admission activity;adverse maternal outcomes;adverse pregnancy outcome;Affect;Algorithms;antenatal;Anti-Hypertensive Agents;arteriole;Blood Pressure;blood pressure control;Blurred vision;Brain;Brain Injuries;brain tissue;Caliber;cerebral autoregulation;Cerebral Edema;Cerebral hemisphere hemorrhage;cerebral hypoperfusion;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Spasm;Cerebrum;Clinical;clinical care;Clinical Research;Data;disability;Discipline of obstetrics;Ensure;experience;Feasibility Studies;Functional disorder;Funding;Goals;Guidelines;Headache;Hemorrhage;high reward;high risk;Homeostasis;Hospitalization;Hour;Hypertension;Impairment;improved;indexing;Individual;Injury;Intensive Care Units;Intervention;Intracranial Hypertension;Intravenous;Ischemia;Ischemic Stroke;Life;Magnesium;Maternal Mortality;Measures;Methods;Modality;Monitor;Near-Infrared Spectroscopy;Nervous System Trauma;Neurologic;Neurologic Symptoms;novel;novel strategies;Outcome;Pain;Patients;people of color;Perfusion;personalized approach;Phase;Phase II Clinical Trials;portability;postpartum complications;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnant;pressure;prevent;Proxy;randomized, clinical trials;Recommendation;response;Risk;Risk Reduction;severe maternal morbidity;Stroke;System;TBI Patients;Testing;Time;tissue oxygenation;United States National Institutes of Health;Women's Health

PROJECT_TITLE: PROtecting Maternal brains from Injury and Stroke (PROMIS): a Single-center Phase 2 Clinical Trial

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Cancer;Hematology;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This program is designed to train the next generation of leaders in pediatric hematology-oncology biomedical science. The focus is on providing a strong guidance and mentoring around investigations pertaining to areas of clinical and basic research at the forefront of pediatric hematology-oncology including, but not limited to, genomics, epigenomics, developmental biology, cellular therapies, clinical trial design, and survivorship. Qualified trainees, both MD’s and MD/PhD’s, will be selected for their potential to assume academic positions in pediatric departments at major medical schools. The training program compliments multiple other existing training programs in the Department of Pediatrics and the Washington University School of Medicine.

PI_NAMEs: DI PAOLA, JORGE A;RUBIN, JOSHUA B (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Pediatric Training Program Hematology and Oncology


ADMINISTERING_IC: LM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE New biological and biomedical data are now collected in unprecedented pace and analyzing such complex data has become a research bottleneck. Graphical causal models have recently emerged as attractive methods to model complex systems because of their flexibility, efficiency and interpretability, but they have limitations on the types of data and size of datasets they can process. In this project, we are proposing to develop new causal learning methods for a variety of datasets; and test them on synthetic and real-life data.

PI_NAMEs: LOVELACE, TYLER  (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Address;Algorithms;analytical method;Automobile Driving;Biological;Black Box;cancer care;causal model;cell type;Cells;Clinical;clinically relevant;cohort;Complex;complex data;coping;Data;Data Analytics;Data Set;Development;dimension reduction;Dimensions;Event;experimental study;Explosion;flexibility;gene regulatory network;Generations;Genes;Graph;graph learning;Heterogeneity;high dimensionality;Immunologics;improved;Individual;Intensive Care Units;Intervention;Intubation;Investigation;Learning;learning algorithm;learning strategy;Life;machine learning method;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;Medicine;method development;Methodology;Methods;Mining;model design;Modeling;mortality;Mortality Determinants;Motivation;multidimensional data;multiple omics;novel;Outcome;Patients;Performance;Periodicity;Phenotype;predictive modeling;Process;prognostic model;Property;Research;Research Personnel;Resolution;RNA;single-cell RNA sequencing;Skeleton;Structure;synthetic data;System;Testing;The Cancer Genome Atlas;Time;tool;Validation;vector;Ventilator;Work

PROJECT_TITLE: Causal graphical methods for high-dimensional heterogeneous biomedical data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Lung;Lung Cancer;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: Inflammation in the lungs can contribute to lung cancer development and progression, and men are at greater risk of dying from lung cancer. This project studies the role of the estrogen receptor signaling on tumor promoting inflammation and thereby cancer development. The results will create a framework for tailored treatment based on a patient’s sex to treat their cancer more effectively.

PI_NAMEs: CLOWERS, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Ablation;Bone Marrow Transplantation;cancer clinical trial;Cancer Etiology;cancer type;carcinogenesis;cell type;Cells;Cessation of life;cigarette smoke;Clinical Trials;comparison control;Development;DNA Sequence Alteration;driver mutation;druggable target;Epithelium;ESR1 gene;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Female;female sex hormone;Genes;Genetic;Genotype;Goals;Gonadal Steroid Hormones;Immune;Immunotherapy;individualized medicine;Infiltration;Inflammation;Inflammatory;inhibitor;interest;Interleukin-6;Knock-out;Lung;Lung Neoplasms;male;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;men;Modality;Modeling;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myelogenous;Myeloid Cells;neoplastic cell;novel therapeutics;Nuclear Hormone Receptors;Outcome;Pathway interactions;Patients;personalized medicine;Phenotype;Play;Production;Proliferating;promoter;Protein Isoforms;Rattus;receptor binding;Receptor Gene;Receptor Signaling;recruit;resistance mechanism;resistance mutation;Risk;Role;Sarcoma;sex;sex disparity;Signal Transduction;single-cell RNA sequencing;Smoker;STAT3 gene;Structure of parenchyma of lung;System;targeted treatment;Testing;transcription factor;tumor;Tumor Burden;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor-infiltrating immune cells;tumorigenesis;United States;Viral Oncogene

PROJECT_TITLE: Estrogen receptors restrict tumor-promoting inflammation in K-ras mutant lung cancer


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Addictive opiate drugs such as morphine and heroin activate the same cellular receptors as endogenous opioid neuropeptides, yet produce pathological effects after prolonged or repeated administration. We seek to understand the underlying cell biology and biochemistry of these drug effects that yield new insights to pathology or new therapeutic targets for the treatment of opiate tolerance, dependence and addictive disorders. Beyond specific relevant to opioid receptors, the proposed studies address mechanistic aspects of GPCR signaling and regulation with broad biomedical relevance.

PI_NAMEs: VONZASTROW, MARK E (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acceleration;Adaptor Signaling Protein;addiction;Address;Adenylate Cyclase;ADRBK1 gene;Agonist;Animals;Arrestins;Bar Codes;Behavior;beta-arrestin;Binding;Biochemical;Biochemistry;Biological Assay;Catalytic Domain;Catecholamine Receptors;Cell membrane;Cell model;Cell Physiology;Cells;Cellular biology;coated pit;Cyclic AMP;Cytoplasm;Cytoplasmic Receptors;Cytoplasmic Tail;Dependence;Diffuse;Disparate;Dissociation;drug action;drug discovery;drug discrimination;drug of abuse;Drug Regulations;Drug Targeting;Endocytosis;endogenous opioids;Endosomes;Equilibrium;flexibility;Foundations;fundamental research;Funding;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Goals;GTP-Binding Proteins;Heroin;Individual;insight;Intracellular Membranes;Knowledge;Ligands;Location;Maps;Mass Spectrum Analysis;Mediating;Methods;Molecular;Morphine;Mutation;neural circuit;Neuromodulator Receptors;Neurons;Neuropeptides;neurophysiology;new therapeutic target;operation;opiate tolerance;Opioid;Opioid Receptor;Pathologic;Pathology;Pattern;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Physiological;Process;Production;programs;protein activation;Protein Engineering;Protein Isoforms;Proteins;receptor;Receptor Activation;Receptor Signaling;receptor-mediated signaling;recruit;Regulation;Research;Role;Signal Transduction;spatiotemporal;structural determinants;Structural Protein;Tail;targeted treatment;Testing;Therapeutic;trafficking

PROJECT_TITLE: Mechanisms and Cellular Function of Opioid Receptor Endocytosis

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Keeping heart failure patients at home with a low symptom burden after hospital discharge is challenging. This project aims to adapt a computer-interface telephonic interactive voice response system that monitors symptoms and provides real-time, self-management coaching messages based on heart failure patient- reported outcomes. This system has the strong potential to be widely disseminated into clinical practice leading to improved patient outcomes through better self-management behaviors.

PI_NAMEs: KANG, YOUJEONG  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: acceptability and feasibility;acute care;Algorithms;Area;Attention;Behavior;care systems;career;career development;Caring;Chemotherapy-Oncologic Procedure;clinical practice;Clinical Trials;Clinical Trials Design;Collaborations;Computer Interface;Data;Development;Disease;Emergency department visit;Ensure;evidence base;experience;Feedback;Future;Goals;Guidelines;Health;health care settings;Health Care Visit;Health system;Heart failure;Home;Home Care Services;hospital readmission;Hospitals;improved;innovation;Inpatients;Instruction;International;Intervention;Leadership;Malignant Neoplasms;Measures;Medical;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Monitor;Oncology;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Phase;Pilot Projects;Positioning Attribute;prevent;Quality of life;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;response;Review Literature;Self Management;Severities;skills;Stable Disease;Statistical Data Interpretation;successful intervention;Symptom Burden;symptom management;Symptoms;System;Technology;telemonitoring;Telephone;Testing;Time;treatment as usual;Treatment Failure;Universities;Utah;Voice;Weight;Work

PROJECT_TITLE: Symptom Care at Home-Heart Failure: Developing and piloting a symptom monitoring and self-management coaching system for patients with heart failure

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative To address the critical need for empirically supported non-pharmacological interventions for attention-deficit/ hyperactivity disorder (ADHD), we will test Trigeminal Nerve Stimulation (TNS), a novel, minimal risk, non- invasive neuromodulation treatment, within a large independent sample of children aged 7-12 years old at two independent research sites (UCLA, Seattle Children’s Research Institute). In addition, we will test the underlying neural mechanism of TNS treatment as a mediator of ADHD symptom change. Finally, we will identify baseline behavioral and cognitive predictors of positive treatment response to TNS in order to inform a personalized treatment approach.

PI_NAMEs: LOO, SANDRA K (contact);MCGOUGH, JAMES JOHN;WEBB, SARA JANE

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: 12 year old;Address;Age;aged;Attention deficit hyperactivity disorder;attentional control;Behavior;behavior prediction;Behavioral;Biological Markers;Brain;burden of illness;Caring;Characteristics;Child;Clinical;clinical heterogeneity;Cognitive;cognitive function;Communities;confirmatory trial;Consumption;cost;cost effective;Data;Development;Devices;Double-Blind Method;Effectiveness;efficacious intervention;efficacious treatment;efficacy testing;Electroencephalography;Ensure;Exhibits;Family;follow-up;Frequencies;Functional disorder;High Prevalence;Home;impression;improved;indexing;Individual;informant;innovation;Intervention;Literature;Measurement;Mediating;Mediator;metacognition;Methods;minimal risk;Minority;National Institute of Mental Health;neuromechanism;neuroregulation;non-compliance;Nonpharmacologic Therapy;novel;Outcome;Parents;Patients;personalized medicine;Pharmaceutical Preparations;Pilot Projects;placebo group;predicting response;Prediction of Response to Therapy;primary outcome;prospective;Psychiatry;psychostimulant;Quality of life;Randomized;randomized, clinical trials;reduce symptoms;Research;Research Institute;Research Priority;Research Support;response;Rest;Sample Size;Sampling;secondary outcome;Short-Term Memory;side effect;Site;Sleep;societal costs;standard care;Symptoms;Targeted Research;teacher;Testing;Time;treatment arm;treatment effect;treatment response;treatment strategy;Trigeminal nerve structure;Validation;Youth

PROJECT_TITLE: Efficacy of External Trigeminal Nerve Stimulation for Treatment of ADHD


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: NARRATIVE The proposed research is relevant to human health because it addresses a longstanding need to understand why some cancers respond to treatment and others do not. We anticipate our studies to initiate an innovative new approach to cancer research, with the ability to predict which of many possible pathways are disrupted in any given cancer solely from DNA sequence, thereby suggest treatments for otherwise intractable cancers.

PI_NAMEs: GILBERT, DAVID M (contact);KEREM, BATSHEVA

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Affect;anti-cancer research;Aphidicolin;Appearance;Architecture;Biological Assay;Cancer Biology;cancer diagnosis;cancer therapy;cancer type;CCNE1 gene;Cell Culture Techniques;Cells;Chemicals;Chimeric Proteins;Chromosomal Breaks;Chromosome Fragile Sites;Chromosomes;clinically relevant;Complex;Cultured Cells;Data;Development;DNA Sequence;druggable target;Evolution;experience;Frequencies;Genetic Transcription;Genomic Instability;Genomics;Goals;Health;Heterogeneity;Hot Spot;Human;improved;In Vitro;in vivo;innovation;Link;Location;Malignant Neoplasms;Maps;Metaphase;Methods;Minority;Mitosis;molecular sequence database;Monitor;new technology;novel strategies;Oncogenes;Oncogenic;overexpression;Pathway interactions;Pattern;Pharmaceutical Preparations;precision oncology;prediction algorithm;Prognosis;prospective;Rejuvenation;Replication Initiation;replication stress;Research;Resolution;response;Role;S phase;Sequence Analysis;Site;Specific qualifier value;Specificity;Stress;stressor;Structure;System;Testing;tumor;tumor progression;Variant;whole genome

PROJECT_TITLE: Oncogenic pathway-induced fragile sites: a new paradigm for understanding genome instability in cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Colorectal Cancer;Digestive Diseases;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE The burden of cancer in Nigeria, Africa's most populous country, is large and growing, and there is a need for increased research capacity to generate evidence to inform effective treatments, cancer control programs, and policies. To meet this need, we will leverage a highly successful research partnership between Memorial Sloan Kettering Cancer Center (US), Obafemi Awolowo University (Nigeria), and the College of Medicine at the University of Lagos (Nigeria) to establish an international research training program aimed at creating a cohort of highly skilled Nigerian investigators able to lead independent oncology research programs, fostering team science, bolstering research administration capacity in Nigeria, and creating long-term research partnerships between Nigerian and US cancer researchers.

PI_NAMEs: ALATISE, OLUSEGUN ISAAC;KINGHAM, T PETER (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: anti-cancer research;Area;Behavioral Sciences;Biometry;cancer epidemiology;Cancer Patient;cancer therapy;Caring;Clinical;clinical practice;Collaborations;college;Colorectal Cancer;Country;design;Development;Discipline;Discipline of Nursing;Doctor of Philosophy;E-learning;Evidence based intervention;Foundations;Goals;hands on research;Health;Health Policy;Incidence;Individual;Infrastructure;Institution;Malignant Breast Neoplasm;Malignant Neoplasms;medical specialties;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;multidisciplinary;Nigeria;Nigerian;Nurses;Nursing Faculty;Oncology;Outcome;Physicians;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Training;Science;Solid;Teaching Hospitals;Training;Training Programs;Universities

PROJECT_TITLE: Expanding cancer research capacity in Nigeria with team science


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Creating an effective and scalable weight loss intervention is fundamental to treating obesity on a population level. This proposal seeks to optimize a standalone digital intervention for weight loss by identifying which self- monitoring components (tracking diet, physical activity, or body weight), alone or in combination, maximize success while minimizing burden. This line of work has potential for important public health impact by enhancing weight loss in digital treatments that can reach broad populations of adults with overweight/obesity.

PI_NAMEs: PATEL, MICHELE LANPHER (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Accelerometer;Address;Adult;behavior change;Behavior monitoring;Behavior Therapy;Behavioral;Body Weight;Body Weight Changes;Body Weight decreased;career;Cellular Phone;Chronic Disease;Clinical;Clinical Trials;clinically significant;collaborative environment;combat;cost;Coupled;Data;Dedications;Demographic Factors;design;Diet;Dietary intake;digital;digital health;digital intervention;digital tool;digital treatment;Eating;Energy Intake;Enrollment;ethnic minority;Evaluation;Feedback;Goals;Grant;innovation;insight;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Measures;Mentors;Mentorship;Methodology;Methods;mobile application;Monitor;multiphase optimization strategy;novel;Obesity;obesity treatment;Outcome;Overweight;Paper;Participant;Patients;Persons;Phase;Physical activity;Population;portability;Positioning Attribute;post intervention;Preparation;Process;programs;Psychosocial Factor;Public Health;Qualifying;racial minority;Randomized;randomized trial;recruit;remote delivery;Research;Research Methodology;Research Personnel;Resources;retention rate;Risk;secondary outcome;skills training;Structure;success;Testing;theories;Training;Universities;wearable device;Weight;weight loss intervention;wireless electronic;Work

PROJECT_TITLE: Optimizing self-monitoring in a digital health intervention for weight loss

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Pain Research;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative Oral cancer patients suffer from severe, chronic pain, which is induced by release of mediators from the cancer that act on nearby sensory nerves. Sensitized nerves, in turn, secrete factors that potentially modulate growth and metastasis of the cancer. Whilst nerves and epithelial cells normally interact in healthy tissues, a better understanding of the disturbed interactions that occur in cancer can lead to new ways to both treat cancer and alleviate cancer pain.

PI_NAMEs: ALBERTSON, DONNA G (contact);SCHMIDT, BRIAN L

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: afferent nerve;Afferent Neurons;Agonist;angiogenesis;Attention;Attenuated;attenuation;Behavior;Behavioral;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;cancer cell;cancer pain;Cancer Patient;cancer therapy;Capsaicin;carcinogenesis;Cell Line;Cells;Chemicals;chronic pain;Clinical Trials;cohort;Data;density;Disseminated Malignant Neoplasm;Enrollment;Epithelial Cells;experience;extracellular vesicles;FDA approved;Foundations;Ganglia;Genes;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Hyperalgesia;immunoreactivity;improved;Incidence;innovation;Invaded;malignant mouth neoplasm;Malignant Neoplasms;Measurable;Measures;mechanical allodynia;Mediator;member;MicroRNAs;Migraine;Modeling;mouse model;Mus;Neoplasm Metastasis;Nerve;nerve supply;Neurons;Neuropeptides;neuroregulation;Nociception;Nociceptive Stimulus;Nociceptors;Nodal;Nonmetastatic;novel strategies;Opioid;oral carcinogenesis;oral pain;overexpression;Pain;Pain Measurement;Painless;Patients;Peptide Signal Sequences;perineural;Phenotype;prevent;Proliferating;prospective;Proteins;Reporting;Research;response;Rodent Model;Sampling;Sensory;Signal Transduction;Spinal Ganglia;spinal nerve posterior root;Stains;Stimulus;Stromal Cells;Structure of trigeminal ganglion;targeted treatment;Testing;Tissues;Trigeminal System;TRPV channel;TRPV1 gene;tumor microenvironment

PROJECT_TITLE: TRPV1 nociceptors in oral carcinogenesis and pain


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Currently, 1.5 million older adults live in Long Term Care (LTC) facilities in the United States and that number is increasing. Their need for dental care is also growing since almost 70% of older adults are now dentate. This project will utilize the WHO health systems thinking framework and the companion Health service co-design tool kit to co-create with stakeholders a systems level intervention to prevent caries and periodontal disease in this vulnerable population.

PI_NAMEs: HENSHAW, MICHELLE M (contact);TURTON, BATHSHEBA

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Acceleration;Address;Adopted;Adult;Alveolar Bone Loss;care systems;Caring;Child;Clinical;Clinical Data;Clinical Research;Clinical Trials;Cohort Studies;Communities;comorbidity;Companions;Complex;Computer software;Coupled;Data;Dental;Dental Care;Dental Care Delivery;Dental caries;Dental Hygiene;Dental Plaque;Dentists;Dependence;design;Diagnosis;Disease;Disease Management;Disease Progression;disorder prevention;Elderly;Emergency Situation;evidence base;experience;Feedback;Fluoride Varnishes;Focus Groups;frailty;Grant;Health;health care delivery;Health care facility;health inequalities;Health Services;Health Services Accessibility;Health Status;Health system;Healthcare;human old age (65+);improved;Incidence;Infrastructure;Intervention;intervention effect;Investigation;Lesion;Logic;Long-Term Care;Maps;Medicaid;Medical;Methods;Modeling;models and simulation;Mouth Diseases;Obesity;older adult;Oral;Oral health;Pathway interactions;Patients;Pattern;Patterns of Care;pediatrician;Periodontal Diseases;Polypharmacy;population health;Prevalence;prevent;Prevention;Preventive;Preventive care;Process;Protocols documentation;Public Health;Public Policy;Quality of life;Research;Research Personnel;response;restorative treatment;Risk;Series;Severities;social;Structure;Support System;System;Testing;therapy design;Thinking;Time;tool;Tooth Tissue;Training;Treatment Efficacy;treatment group;trial planning;United States;Vulnerable Populations;Work;World Health Organization

PROJECT_TITLE: Oral Disease Prevention Model in Long Term Care: WHO Systems Thinking Framework

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Nonalcoholic fatty liver disease is a common and serious metabolic disease with no effective therapies. Our understandings of the factors that drive disease progression and resolution remain very limited. We propose to use a combination of genetic and disease models and state-of-the-art genomic tools to investigate a new signaling pathway in fatty liver disease and explore its potential for therapeutic development.

PI_NAMEs: LIN, JIANDIE D (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: Ablation;Address;Automobile Driving;Binding;Biology;Brain-Derived Neurotrophic Factor;Cell Death;cell type;Cells;Chimeric Proteins;Data;design;Diet;Disease;disease model;Disease Progression;effective therapy;efficacy evaluation;Fatty Liver;fatty liver disease;feeding;Fibrosis;Functional disorder;Future;Genetic Models;genomic tools;Hepatic;Hepatocyte;hepatocyte injury;Heterogeneity;Human;improved;Inflammation;Injury;insight;intrahepatic;Knockout Mice;Knowledge;Length;Ligands;Link;Liver;Liver diseases;liver injury;Mediating;Metabolic;Metabolic Diseases;Metabolic stress;Modeling;Molecular;Mus;Nature;NF-kappa B;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutics;overexpression;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phosphotransferases;pre-clinical;protective effect;Protein Isoforms;Proteins;receptor;Recombinants;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Stress;Testing;Therapeutic;therapeutic development;tool;transcriptomics;Translational Research;Treatment Efficacy;Tropomyosin;Work

PROJECT_TITLE: Hepatic TrkB-T1 signaling in NASH pathogenesis and resolution

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Emergency Care;Health Services;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Violence Research

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: Project narrative  The recent Russian invasion of Ukraine exposed millions to severe stress/trauma, and the  mental health sequela is tremendous while the resource and knowledge to implement  evaluate and provide necessary care are extremely limited. In partnership with the premier  academic institution in Ukraine, and Ukraine Government initiative focused on trauma  research, this project will build research capacity to (a) incorporate trauma-based  knowledge and treatment (b) build translational interventions that would utilize it trauma  care (c) implement research to evaluate effectiveness. Capacity building would take place  through in-country workshops, continuous learning, and research fellowship, with later-  stage work aimed at changing policy at the national level about how to address this critical need

PI_NAMEs: LIBERZON, ISRAEL  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Academy;Anxiety;Area;base;Caring;Chronic;Clinical;Collaborations;combat;Conflict (Psychology);Country;Data;design;Education;Educational workshop;Epidemiology;evidence base;experience;Exposure to;Faculty;Functional disorder;Funding;Goals;Health Care Reform;Health Professional;Healthcare;implementation intervention;implementation outcomes;Individual;interest;Invaded;Knowledge;Mental Depression;Mental Health;Mental Health Services;Mentors;Michigan;Military Personnel;Outcomes Research;Persons;Physicians;pilot test;Post-Traumatic Stress Disorders;Postdoctoral Fellow;programs;psychological distress;Psychologist;Reading;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Schools;Scientist;Stress;Supervision;Time;Training;Trauma;trauma care;Trauma Research;Treatment Efficacy;Ukraine;Universities;Violence;War;Work

PROJECT_TITLE: Building Research Capacity for Implementation of Outcomes Research and Evidence-Based trauma care after Mass Violence, in Ukraine.


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PHR: RELEVANCE TO PUBLIC HEALTH, PROJECT NARRATIVE Saccharomyces cerevisiae is a model for understanding eukaryotic genetics, genome maintenance and regulation, and cellular processes. S. cerevisiae informs genetic medicine via annotation of human disease-related phenotypes and gene function through functional complementation between yeast and human homologs. SGD provides a comprehensive online resource that facilitates experimentation and computational analysis to understand fundamental biological processes.

PI_NAMEs: SHERLOCK, GAVIN J (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adopted;Attention;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Process;biological systems;Biology;Biomedical Research;Cell Physiology;Cells;citizen science;cloud storage;Collaborations;Communities;Complement;Computer Analysis;Computer software;Controlled Vocabulary;Data;data integration;data standards;Databases;design;Development;Documentation;Education and Outreach;Elements;Eukaryota;experimental analysis;gene function;gene product;Genes;Genetic;genetic information;Genetic Medicine;Genome;genome annotation;genome database;genome resource;Genomic medicine;Genomics;Goals;heterogenous data;Homologous Gene;Human;Human Biology;human disease;improved;Internet;Knowledge;Learning;Learning Module;Lighting;Literature;Maintenance;Maps;member;Metadata;Modeling;Molecular;new technology;novel;online resource;Ontology;Paper;pedagogy;Phenotype;Public Health;Regulation;Research;Resources;Saccharomyces;Saccharomyces cerevisiae;Saccharomycetales;Scientist;service organization;Services;synergism;text searching;tool;tool development;Update;Variant;Work;Yeasts

PROJECT_TITLE: Genomic Resource for the Yeast Saccharomyces


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Narrative Diseases caused by mixtures of bacteria are often more serious and harder to treat that those caused by a single organism. Periodontal (gum) diseases are caused by mixtures of microbes that communicate with each other to regulate the level of disease-causing potential of the microbial community. In this proposal we shall study the communication mechanisms that allow periodontal bacteria to increase production of toxic products, become more metabolically active, and resist killing by the host.

PI_NAMEs: LAMONT, RICHARD J (contact);POTEMPA, JAN S;URIARTE, SILVIA M

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Abscess;Alveolar Bone Loss;Amino Acids;Bacteria;Benzoic Acids;Binding;C-terminal;Calibration;Carbon;Communication;Communities;community partners;Complex;Cues;Data;design;Development;Dimensions;Disease;disease model;dysbiosis;Environment;Enzymes;Equilibrium;Event;Excision;extracellular;Feedback;Folic Acid;Functional disorder;Fusobacterium nucleatum;gingipain;Goals;Human;Immune response;in vivo;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Measures;Mediating;Metabolic;Metabolism;Microbe;microbial community;Modeling;Molecular;Mus;N-terminal;neutrophil;Neutrophil Activation;Neutrophil Infiltration;novel;oral infection;oral plaque;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptide Hydrolases;Peptides;Periodontal Diseases;Phosphorylation;Physiological;Physiology;polymicrobial disease;Polysaccharides;Porphyromonas gingivalis;prevent;Process;Production;Property;Protein Tyrosine Kinase;Proteins;Regulation;response;Role;Shapes;Signal Transduction;Signaling Molecule;Streptococcus;Streptococcus gordonii;System;Testing;Therapeutic;Tissues;Translating;Tyrosine Phosphorylation;Virulence;Virulence Factors;Work

PROJECT_TITLE: Molecular Aspects of Oral Plaque Formation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Persistent Jak2 signaling in myeloproliferative neoplasm (MPNs) defined as Philadelphia chromosome negative (Ph-) myeloproliferative disorders (MPDs) provided rationale for the targeted anti-Jak2 tyrosine kinase inhibitor (TKI). However, unlike the efficacy of ABL inhibitors in eliminating the leukemic cells in Ph+ MPN, Jak2 mutant clones are resistant to JAK2 inhibitor treatment. Here we provide molecular insight how MAPK feed-back regulation by DUSP1 protect the Ph- cells from TKI induced cell death and demonstrate that blocking DUSP1 activity leads to effective elimination of MPN cells. While the project focuses on MPN (the paradigm for TKI therapy), the findings should be readily translatable to kinase-addicted diseases.

PI_NAMEs: AZAM, MOHAMMAD  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: abl Genes;Ablation;Acceleration;Acute;Acute Myelocytic Leukemia;analog;Anemia;anti-cancer treatment;Apoptotic;BCR gene;bcr-abl Fusion Proteins;Bone Marrow;cancer cell;Cell Death;Cell Death Induction;Cell Physiology;Cells;Chemicals;Chromosome 22;Chromosome 9;Chromosomes;Chronic Neutrophilic Leukemia;Classification;Clinic;Clinical;clinical application;Clinical Trials;Constitutional Symptom;curative treatments;cytokine;cytotoxicity;Data;Defect;Dendritic Cells;Dependence;Development;Disease;Disease remission;DNA Sequence Alteration;DUSP1 gene;efficacy testing;Embryo;experimental study;Failure;Feedback;FOS gene;Generations;Genetic;Genetic Models;Granulocyte Colony-Stimulating Factor Receptors;Growth Factor;Growth Factor Receptors;Hematological Disease;Hematology;Hematopoietic;hematopoietic tissue;Hemorrhagic Thrombocythemia;Immunosuppression;improved;In Vitro;infection rate;Inflammatory;inhibitor;inhibitor therapy;insight;JAK2 gene;kinase inhibitor;leukemia;leukemia initiating cell;Leukemic Cell;leukemic stem cell;Malignant - descriptor;Malignant Neoplasms;MAP Kinase Gene;MAPK phosphatase;Mediating;Mediator;Medicine;Modeling;Molecular;Molecular Target;mouse model;Mus;mutant;Mutation;Myeloid Cells;Myeloproliferative disease;Nature;Normal Cell;oncogene addiction;Organ;overexpression;Patients;peripheral blood;pharmacokinetics and pharmacodynamics;pharmacologic;Philadelphia;Philadelphia Chromosome;Phosphotransferases;Polycythemia Vera;Population;pre-clinical;prevent;Primary Myelofibrosis;Production;Proliferating;Publishing;Reciprocal Translocation;Refractory;Regulation;Relapse;Research;research clinical testing;Residual Neoplasm;Resistance;response;Role;Signal Transduction;small molecule;small molecule inhibitor;Solid;Specificity;Specimen;Structure;Structure-Activity Relationship;Symptoms;Testing;therapeutic target;Thrombocytopenia;Toxic effect;Treatment Efficacy;treatment response;tumor;Tyrosine Kinase Inhibitor;Tyrosine-Kinase Oncogenes

PROJECT_TITLE: Target the Dusp1 in Jak2 dependent myeloproliferative neoplasm (MPN) for curative treatment


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Neurosciences;Pediatric;Stroke

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Rupturing of arteriovenous malformation (AVM) in the brain is a serious medical problem that can cause significant morbidity and mortality, and often requires urgent embolization to stop bleeding. Currently used FDA approved liquid embolic agents for brain AVMs are associated with significant limitations, including toxicity from organic solvents, difficulty in delivery, danger of being washed away, lack of universality to block wide range of vasculature sizes, no intrinsic radiopacity for visualization on X-ray, and lack of therapeutic treatment. To address the aforementioned issues, we propose to develop biocompatible injectable gel embolic agents that are visible on various imaging modalities, offer flexibility to penetrate varying AVM vasculature geometry and serve as therapeutic carrier for the minimally invasive treatment of brain AVMs.

PI_NAMEs: HU, JINGJIE  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acute;Address;Adhesives;Alcohols;Alginates;Aneurysm;angiogenesis;Animal Model;Animals;Anti-Bacterial Agents;Anti-Inflammatory Agents;Arteries;Arteriovenous malformation;Biocompatible Materials;Biological;biomaterial compatibility;Biomedical Engineering;Blood;Blood capillaries;Blood Vessels;Brain;brain arteriovenous malformations;Brain hemorrhage;Bypass;Cardiovascular system;Catheters;Cell Line;Cerebral hemisphere hemorrhage;Characteristics;Circulation;Clinical;clinically relevant;Coagulation Process;Contrast Media;cost;Crosslinker;curative treatments;Cyanoacrylates;Death Rate;Defect;design;Development;Dimethyl Sulfoxide;disability;Distal;Drug Carriers;Drug Delivery Systems;Engineering;Ensure;Ethylenes;Evaluation;Exhibits;experience;Failure;Family suidae;FDA approved;feeding;Fibrinolysis;flexibility;Fluoroscopy;Formulation;Gel;genipin;Geometry;Growth;Headache;Hemorrhage;Hemostatic Agents;Hypertension;imaging agent;imaging modality;In Vitro;in vivo evaluation;Inflammation;Inflammatory Response;Injectable;Injections;Intracranial Hemorrhages;Iohexol;Liquid substance;Magnetic Resonance Imaging;malformation;mechanical properties;Mechanics;Medical;microCT;Microsurgery;migration;minimally invasive;Modeling;Morbidity - disease rate;mortality;Nature;Neurofibrillary Tangles;Neurologic Deficit;Organic solvent product;Penetration;Performance;Pharmacotherapy;Pilot Projects;Plasma;polymerization;Polymers;prevent;Property;Radiosurgery;Recurrence;regenerative;Research Support;Resistance;Risk Reduction;Roentgen Rays;Rupture;Safety;Seizures;Shunt Device;Site;Solid;Solvents;stem;Stress;Survivors;System;Testing;Therapeutic;Therapeutic Embolization;Thinness;thrombogenesis;Thrombus;Time;Tissues;Toxic effect;Travel;tumor;Veins;Venous;Venous Pressure level;Visualization;Work;X ray visualization

PROJECT_TITLE: Developing Therapeutic Gel Embolic Agents for Arteriovenous Malformation Embolization


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Contraception/Reproduction;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Women's Health Research

PHR: Project Narrative: Toxoplasma gondii infects a third of the global population and, when contracted by a pregnant woman, can cause severe disease in the developing fetus. In order to reach the fetus, T. gondii must surmount the placenta, an organ that has evolved specifically to restrict pathogens. This proposal investigates how T. gondii manipulates the development and function of placental cells to facilitate its own transmission.

PI_NAMEs: CABO, LEAH FRANCES (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Arteries;Automobile Driving;Biological Markers;Biology;Blood Circulation;blood perfusion;Cell Differentiation process;Cell Line;Cell Physiology;cell type;Cells;Congenital Abnormality;congenital infection;Congenital Toxoplasmosis;Contracts;cost;Cytomegalovirus;cytotrophoblast;Data;Development;Developmental Biology;Diffuse;Disease;Elements;embryo cell;Endometrium;Eye diseases;fetal;Fetal Development;fetal infection;Fetus;Future;Gene Expression Profile;Human;Immunofluorescence Immunologic;In Vitro;in vivo;Infection;insight;Invaded;knock-down;Lifelong disability;Live Birth;Maps;Mediating;member;Mesenchymal;Metabolic;Modeling;Molecular;Mothers;mRNA sequencing;Multipotent Stem Cells;neglect;Nervous System Trauma;Nutrient;Organ;Organoids;Oxygen;Parasites;Parasitic infection;Parasitology;pathogen;Perinatal Infection;permissiveness;Physiology;Placenta;placental trophoblasts;Placentation;Population;Predisposition;Pregnancy;Pregnant Women;Process;progenitor;Proliferating;Resistance;Rubella;secondary infection;Signal Transduction;stem cell fate;stem cell function;stem cell model;stem cell population;stem cells;success;Syncytiotrophoblast;System;Testing;Time;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcription factor;transcriptome;transmission process;trophoblast;trophoblast stem cell;Villous;Work;wound healing;ZIKA

PROJECT_TITLE: Developmental disruption in the transplacental transmission strategy of Toxoplasma gondii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-A(20)L]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Physical Rehabilitation;Rehabilitation

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative The proposed 2023-2028 Johns Hopkins University, Tanzania Red Cross Society and Muhimbili University School of Public Health and Social Sciences Education and Mentoring Program On Surgical Work and Rehabilitation in Tanzania (EMPOWER-TZ) will strengthen research capacity to address surgery, rehabilitation, and humanitarian health in Tanzania, a middle-income country in east Africa where the burden of surgical problems among refugees are twice that of non-refugee settings in low- and middle-income countries. The program will utilize long-, medium-, and short-term training opportunities to build capacity for implementation science research of surgery, rehabilitation, and humanitarian health, while simultaneously advancing leadership skills, a national dialogue on these key themes, and sustainable research capacity.

PI_NAMEs: BACHANI, ABDULGAFOOR M. (contact);STEVENS, KENT A

PROJECT_TERMS: Address;Affect;Africa;Ally;Area;burden of illness;Caring;Collaborations;Disease;displaced person;Education;empowerment;Ethics;evidence base;experience;Face;Failure;Goals;Grant;Health;Health Sciences;Health system;implementation science;Individual;Institution;Lived experience;low and middle-income countries;Mentors;Modeling;Operative Surgical Procedures;Outcome;Policies;Population;programs;Public Health Schools;Red Cross;Refugees;rehabilitation science;Rehabilitation therapy;Research;Science;science education;Social Sciences;Societies;surgery outcome;Tanzania;training opportunity;Training Programs;Universities;Work

PROJECT_TITLE: Johns Hopkins, Tanzania Red Cross, and Muhimbili University Education and Mentoring Program On Surgical Work, Research, and Rehabilitation in Tanzania (EMPOWER-TZ)


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Mineralocorticoid receptor (MR) antagonists are a promising class of drugs currently under investigation for heart failure with preserved ejection fraction (HFpEF), a growing cause of illness and mortality, but it remains unclear how these medicines work in HFpEF and which patients they benefit most. Primary aldosteronism (PA) is typically considered a rare cause of severe hypertension and heart disease that can be effectively treated with MR antagonists; however, milder forms of PA are common but underrecognized in all stages of high blood pressure, raising the possibility that PA might also be an unrecognized cause of HFpEF. Our proposed research aims to understand the mechanisms of how PA might lead to HFpEF, using cardiac imaging tools to examine changes in the heart's structure, function, and blood supply, in order to help guide the use of MR antagonists as a targeted treatment for heart failure.

PI_NAMEs: BROWN, JENIFER MICHELLE (contact)

PROJECT_TERMS: Adrenal Glands;Adult;Advisory Committees;Aldosterone;Ammonia;antagonist;atherosclerosis risk;Atherosclerosis Risk in Communities;Award;Biological;Biology;Biostatistical Methods;Blood capillaries;Blood Pressure;Blood Vessels;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;career;career development;Characteristics;Chronic;Chronic Kidney Failure;Clinical;clinical epidemiology;Clinical Research;clinical translation;Clinical Trials;cohort;comorbidity;Coronary Arteriosclerosis;Cross-Sectional Studies;Data;Dedications;design;Development;Development Plans;Diabetes Mellitus;Disease Outcome;Echocardiography;EEF2 gene;EFRAC;endothelial dysfunction;Endothelium;Epidemic;Epidemiologic Methods;Epidemiology;epidemiology study;eplerenone;Essential Hypertension;Exclusion;Extracellular Matrix;Fibrosis;Functional disorder;Functional Imaging;Funding;General Population;Goals;Heart;Heart Diseases;Heart failure;heart imaging;Heterogeneity;High Prevalence;Hormonal;Hospitalization;Hyperaldosteronism;Hypertension;imaging biomarker;Imaging Device;Imaging Techniques;improved;improved outcome;Industry;Inflammation;insight;Intervention;Investigation;Ischemia;Kidney;Left Ventricular Remodeling;longitudinal analysis;Measures;Mediating;Medicine;Mentors;Microvascular Dysfunction;Mineralocorticoid Receptor;modifiable risk;mortality;Myocardial;Myocardial perfusion;National Heart, Lung, and Blood Institute;novel;Obesity;Outcome;Oxidative Stress;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;patient population;patient response;patient subsets;Patients;Perfusion;Pharmaceutical Preparations;Phenotype;Physicians;Positron-Emission Tomography;Precision therapeutics;preservation;Prevalence;Prevention;Production;prognostic;Receptor Activation;Registries;Renin;Research;Risk;Risk Factors;Role;Scientist;Severities;Site;skills;Smooth Muscle;Smooth Muscle Myocytes;Spironolactone;Structure;Symptoms;Syndrome;targeted treatment;Techniques;translational scientist;treatment response;United States National Institutes of Health;Vascular blood supply;Vascular Diseases;Vascular Endothelium;Ventricular Dysfunction;Ventricular Remodeling;Work

PROJECT_TITLE: Cardiac Perfusion, Structure, and Function across the Primary Aldosteronism Spectrum


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative This project will evaluate the genetic etiology of both rare and common forms of infertility and delayed puberty. During the K99 phase, the proposal will apply cutting edge genomic analysis techniques to discover novel risk genomic loci in congenital hypogonadism and perform functional analyses in disease relevant cell lines to elucidate the underlying biological mechanisms. Building upon these analyses, in the R00 phase I will explore the genomes of constitutional delayed puberty to identify risk genes and build novel statistical models to associate genomic variation with puberty timing.

PI_NAMEs: ZHAO, XUEFANG  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Age;aggregation database;Anxiety;Area;Award;Bayesian Modeling;biobank;Biological;career;career development;case control;Categories;causal variant;Cell Line;Cell model;Child;Clinical;Code;cohort;collaborative environment;Collection;Committee Members;Constitution;Data;Data Set;de novo mutation;Delayed Puberty;differential expression;Disease;disease phenotype;Endocrine;Endocrinologist;Engineering;Ensure;Etiology;exome sequencing;Failure;Feedback;Foundations;functional genomics;gene discovery;Gene Expression;Gene Frequency;gene network;General Hospitals;Genes;Genetic;Genetic Diseases;genetic pedigree;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genome;genome sequencing;genomic data;genomic locus;Genomic medicine;genomic variation;Genomics;Gonadotropin Hormone Releasing Hormone;Hormone secretion;Human Genome;Hypogonadism;Idiopathic Hypogonadotropic Hypogonadism;Individual;Infertility;innovation;insertion/deletion mutation;insight;Joints;Kallmann Syndrome;Knowledge acquisition;Lead;Leadership;Learning;loss of function mutation;machine learning model;Massachusetts;medical schools;Medicine;Mental Depression;Mentors;Methods;Mutation;Neurons;novel;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Phase;Phenotype;phenotypic data;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;prevent;proband;Process;professor;programs;psychologic;pubertal timing;Puberty;rare condition;Refractory;Regulation;Regulatory Element;Repetitive Sequence;reproductive;Reproductive Biology;Reproductive Endocrinology;reproductive system disorder;Research;research faculty;Research Personnel;Resources;Risk;Risk Factors;risk variant;RNA Sequences;Sampling;Single Nucleotide Polymorphism;skills;Social isolation;Solid;Statistical Methods;Statistical Models;success;Techniques;tool;Training;training opportunity;transcriptome;transcriptome sequencing;transmission process;Untranslated RNA;Variant;whole genome

PROJECT_TITLE: Characterizing the genetic etiology of delayed puberty with integrative genomic techniques

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Microelectrodes implanted in the brain are critical tools for recording and stimulation in neuromodulation approaches to treat a variety of neurological conditions, however, poor long-term stability and functional performance limit their clinical application. The objective of this proposal is to develop iron chelation as a therapeutic approach in intracortical implants, understand the effects of iron accumulation at electrode sites on microglia and neuron degeneration and its impact on electrophysiological signals. Further, the proposal will determine an optimum iron chelator and develop a microelectrode array platform for local delivery of iron chelators at the electrode tissue interface to improve long-term functionality of implanted electrodes.

PI_NAMEs: PRASAD, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acute;Blood Vessels;blood-brain barrier crossing;blood-brain barrier disruption;Brain;brain computer interface;Brain Injuries;brain parenchyma;brain tissue;Catalysis;cell injury;Cell Survival;Cells;Cerebral hemisphere hemorrhage;Chelating Agents;chelation;Chelation Therapy;Chemicals;Chemistry;Chronic;Clinical;clinical application;Data Set;Deep Brain Stimulation;DNA biosynthesis;dosage;drug release profile;Electric Stimulation;Electrodes;Electrophysiology (science);Epilepsy;Erythrocytes;Event;Failure;Foreign Bodies;Free Radicals;functional restoration;Future;Gene Expression;Gilles de la Tourette syndrome;glial activation;Goals;Heme;Hemoglobin;Human;Hydrogels;immune activation;immune modulating agents;Immunohistochemistry;immunoregulation;Implant;implantation;Implanted Electrodes;improved;in vivo;Inflammation;Inflammatory;Injury;Ions;Iron;Iron Chelating Agents;Iron Chelation;iron chelation therapy;Iron Overload;Knowledge;limb movement;Literature;materials science;Mediating;Metabolism;metal chelator;Metals;Methods;Microelectrodes;Microglia;Modeling;Molecular Target;Motor disability;Nerve Degeneration;Nervous System;neural;neural implant;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurological disability;neuron apoptosis;neuron loss;Neurons;neurophysiology;neuroprosthesis;neuroregulation;neurotransmission;non-healing wounds;Outcome;Oxidative Stress;oxygen transport;Paralysed;Parkinson Disease;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;Physiological;Play;Process;protein expression;Proteomics;Publishing;Quantitative Reverse Transcriptase PCR;Reaction;repaired;Reporting;Research;Resolution;response;Role;Route;Secondary to;Series;side effect;Signal Transduction;Site;Slice;Stroke;Surface;Techniques;Therapeutic;Thick;Tissues;tool;transcriptomics;Trauma;Traumatic Brain Injury;Wallerian Degeneration;Work

PROJECT_TITLE: Effects of Iron Accumulation in Intracortical Implants and Protection by Iron Chelation

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Prevention;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Polygenic risk scores (PRS) are set to play a key role in advancing our understanding of the etiology and treatment of disease. While the application of genome-wide PRS is burgeoning across biomedical research, we propose that pathway-specific PRS have even greater potential to provide etiological insights and will help pave the way to precision medicine. Here we introduce a new generation of pathway-specific polygenic risk scores, informed by biological function, and deliver a comprehensive computational tool for their analysis, applying it to perform patient stratification in schizophrenia and bipolar disorders.

PI_NAMEs: O'REILLY, PAUL FRANCIS (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adverse effects;Basic Science;Biochemical;Biochemical Pathway;Biological Process;Biomedical Research;Bipolar Disorder;Body mass index;Clinical;Clinical Research;Clinical Trials;Complex;Computer software;computerized tools;Custom;Data;Diagnostic;Disease;Disease susceptibility;disorder risk;Environment;Epigenetic Process;epigenome;Etiology;Failure;Formulation;functional genomics;Future;Generations;Genetic;Genetic Diseases;Genetic Predisposition to Disease;Genetic Risk;genome wide association study;genome-wide;Genomics;Genotype-Tissue Expression Project;Goals;high risk population;Human;In Vitro;Individual;individualized prevention;innovation;insight;Intuition;Link;Location;Mental disorders;Modeling;Multiomic Data;multiple omics;new therapeutic target;next generation;novel strategies;Pathway interactions;patient stratification;patient subsets;personalized medicine;personalized therapeutic;Phenotype;Play;polygenic risk score;Population;portability;precision medicine;Prevention;Production;prototype;Proxy;rare variant;Research;Research Personnel;Resources;Risk;risk variant;Role;Route;Running;Sampling;Schizophrenia;statistical and machine learning;Stratification;Subgroup;success;Symptoms;Testing;Time;tool;trait;transcriptome;treatment response;user-friendly;Variant

PROJECT_TITLE: Next-generation, pathway-specific, polygenic risk scores

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: Project Narrative:  A cardinal trait of the tumor microenvironment is that it is immuno-suppressive, and converting it to one that is immuno-supportive is the key to developing effective immunotherapies that can combat cancer. This proposal focuses on a largely unexplored area of tumor immunology— the metabolic control of T cell function and survival in tumors— and seeks to determine if the deregulated metabolic states of tumor cells directly contribute to the development of an immunosuppressive tumor microenvironment by altering the function, phenotype and metabolic states of tumor infiltrating T cells. This work has the potential to open up a new dimension of immunoregulation in tumors and determine if T cell metabolic reprogramming offers new opportunities for cancer immunotherapy.

PI_NAMEs: KAECH, SUSAN M (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Adopted;aerobic glycolysis;Affect;anti-tumor immune response;Antigen Presentation;Arachidonic Acids;Area;Cancer Biology;cancer cell;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;CD36 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;cell growth;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Characteristics;Clinical;combat;Combined Modality Therapy;Complement;cost;Development;Dimensions;Dinoprostone;Disease;eicosanoid metabolism;Environment;Equilibrium;exhaust;exhaustion;Fatty Acids;flexibility;Frequencies;Functional disorder;Glucose;Glutamine;Goals;Heterogeneity;Homeostasis;Hyperlipidemia;Hypoxia;Immune;immune cell infiltrate;immune checkpoint;Immunity;immunogenicity;Immunologic Surveillance;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;Infiltration;Influentials;Intervention;Learning;lipid biosynthesis;Lipids;Lipolysis;Lipoproteins;Lymphocyte Function;Lymphocytic Infiltrate;Malignant Neoplasms;Melanoma;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;MHC antigen;Modeling;Nature;neoplastic cell;novel;Nutrient;Nutrient availability;nutrient deprivation;oxidized low density lipoprotein;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;Phenotype;Production;programmed cell death ligand 1;programmed cell death protein 1;programs;Proliferating;Prostaglandin D2;Proteins;Resistance;Resources;response;Seminal;Signal Transduction;Source;stem;Stress;T cell infiltration;T cell response;T-Lymphocyte;Testing;Therapeutic;Time;trait;tumor;Tumor Immunity;tumor immunology;tumor metabolism;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Up-Regulation;Work

PROJECT_TITLE: Understanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-Y(55)R]


NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Diabetes;Nutrition;Obesity;Women's Health Research

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Breastfeeding is beneficial for both mother and child; however, mothers with obesity and type 2 diabetes often have insufficient milk production. We hypothesize that adipocytes in the breast tissue interact with the mammary epithelial cells to undergo dramatic remodeling, with play critical roles in establishing breastfeeding, as well as post-weaning lactation suppression and cessation. Our findings will provide fundamental knowledge to the fields of both adipose and mammary gland biology, provide novel insights into lactation and involution complications in women with metabolic disorders.

PI_NAMEs: WANG, QIONG ANNABEL (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Alveolar;alveolar epithelium;Alveolus;Apoptosis;Back;Biology;Breast;Breast Epithelial Cells;Breast Feeding;Cell Communication;Cell Cycle;cell dedifferentiation;Cell Proliferation;Cells;Child;Connective Tissue;Data;Defect;design;Disease;Duct (organ) structure;Ensure;Epithelial Cells;epithelium regeneration;Exhibits;Fatty acid glycerol esters;feeding;Fibrosis;Functional disorder;Health;High Fat Diet;Hormonal;Human;Impairment;In Vitro;in vivo;insight;Insulin Resistance;Knowledge;Lactation;lactogenesis;mammary;mammary epithelium;Mammary gland;Mammary Gland Parenchyma;Metabolic Diseases;Metabolism;Milk;milk production;Modeling;Morphogenesis;Mothers;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;obesity in children;obesity treatment;paracrine;Performance;Phenotype;Play;Pregnancy;Process;Proliferating;Publishing;Risk;Role;self-renewal;Series;Structure;Testing;Time;Tissues;Weaning;WNT Signaling Pathway;Woman;Work

PROJECT_TITLE: Mammary Adipocyte Remodeling in Health and Disease

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: Project Narrative The goal of this pre-clinical proposed study is to identify the role of corticotrophin releasing factor (CRF)-expressing neurons within the lateral habenula (LHb) in regulation of LHb activity and related behavioral anxiety in male and female mice.

PI_NAMEs: NUGENT, FERESHTEH S (contact)

PROGRAM_OFFICER_NAME: TONELLI, LEONARDO HERALDO

PROJECT_TERMS: Anti-Anxiety Agents;Anxiety;anxiety-related behavior;anxiety-related disorders;Applications Grants;Atlases;Axon;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;brain reward regions;Calcium;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRH gene;Cyclic AMP-Dependent Protein Kinases;Darkness;Data;depressive symptoms;Drug Addiction;Electrophysiology (science);Exhibits;experimental study;Female;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;Genetic;genetic approach;Glutamate Receptor;Glutamates;Goals;Habenula;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Image;Immunohistochemistry;In Vitro;innovation;Interneurons;Knowledge;Label;Lateral;Light;LoxP-flanked allele;male;Mediating;Mediator;Mental Depression;Mental disorders;Messenger RNA;motivated behavior;Motivation;mouse genetics;Mus;Negative Reinforcements;neural circuit;neurochemistry;neuronal excitability;Neurons;Neuropeptides;neuroregulation;Neurosecretory Systems;neurotransmission;novel;optogenetics;Phenotype;Play;Population;Positive Reinforcements;postsynaptic;pre-clinical;Predisposition;presynaptic;Proxy;Psychopathology;Publishing;Rattus;receptor;Regulation;release factor;Reporter;Research;response;reward processing;Role;sex;Sex Bias;sexual dimorphism;Signal Transduction;Source;source localization;Stress;stress related disorder;stressor;Synapses;System;Testing;Viral;virus genetics

PROJECT_TITLE: Intrinsic CRF signaling within the lateral habenula

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Chronic Liver Disease and Cirrhosis;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Liver Disease;Nanotechnology;Substance Misuse;Vaccine Related

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative The ongoing intertwined pandemics of viral infections of HIV/AIDS and SARS-CoV-2/COVID-19 and substance use disorders (AUD), unexpectedly bring antiviral drugs and substance abuse disorders together, which severely damage the liver. This project will identify specific off-target(s) of commonly used anti-HIV and anti-COVID-19 drugs, investigate pathogenic mechanisms, and seek therapeutic solutions to mitigate the devastating side effects of antivirals on the liver.

PI_NAMEs: JI, CHENG  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: 2019-nCoV;Acetals;Acquired Immunodeficiency Syndrome;Acute;Address;Affect;AGFG1 gene;Alcohol consumption;alcohol oxidase;alcohol use disorder;Alcohols;Animal Model;Anti-HIV Agents;Anti-viral Agents;antiretroviral therapy;biological adaptation to stress;Blood alcohol level measurement;Buprenorphine;Butyric Acids;Caring;catalase;Cause of Death;Cell Death;Cells;Cellular Stress;chronic alcohol ingestion;comorbidity;Compensation;Coronavirus;COVID-19;COVID-19 patient;COVID-19 vaccine;Development;Dexamethasone;Digestion;Disease;Dose;drug induced liver injury;Drug usage;Drug Use Disorder;efavirenz;Endopeptidases;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Event;Excision;Experimental Models;Family;Fatty Liver;FDA approved;Functional disorder;Genetic;Golgi Apparatus;Hepatic;Hepatocyte;Hepatotoxicity;HIV;HIV Infections;HIV vaccine;HIV/AIDS;Home;Homeostasis;Hospitalization;Human;Immune response;improved;In Vitro;in vivo;Individual;Injury;Life;Link;Liver;Liver diseases;liver injury;Lopinavir;Malignant Neoplasms;Measures;Molecular;Molecular Chaperones;molecular marker;molnupiravir;Monomeric GTP-Binding Proteins;Mus;nanoparticle;next generation;nirmatrelvir;novel;Organelles;Oxidoreductase;pandemic disease;Pathogenicity;Pathway interactions;Patients;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacological Treatment;prophylactic;Proteins;Quality of life;Quarantine;rab GTP-Binding Proteins;Recovery;Regimen;remdesivir;Reporting;response;Risk;Ritonavir;Role;side effect;Signal Transduction;Steatohepatitis;Stress;stress reduction;Substance abuse problem;substance use;Substance Use Disorder;tauroursodeoxycholic acid;Tenofovir;Testing;Therapeutic;Time;trafficking;Transaminases;transcriptome sequencing;vaccine development;Viral;viral pandemic;Virus Diseases;Virus Replication

PROJECT_TITLE: Hepatotoxic mechanisms of anti-HIV- and anti-COVID-19 drugs and substance use disorders