NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: Core D - Project Narrative Myeloproliferative Neoplasms, which include myelofibrosis, are clonal hematopoietic stem cell disorders with limited therapeutic options currently; there is thus a need to develop innovate therapeutic approaches requiring efforts using rational, targeted therapies in order to maximize therapeutic efficacy. The MPN-RC seeks to develop novel therapeutic strategies and understand the disease biology of myelofibrosis. Core D will carry out dynamic analyses of mechanism-based biomarkers, including genomic studies, which pertain to each of the biologic and clinical studies proposed by the MPN-RC, allowing these studies to assess the mechanistic impact of specific therapeutic interventions.

PI_NAMEs: RAMPAL, RAAJIT  (contact)

PROJECT_TERMS: Bioinformatics;Biological;Biological Assay;Biological Markers;Biology;Cells;Clinical;Clinical Research;Clinical Trials;Clonal Hematopoietic Stem Cell;Computer software;Correlative Study;Credentialing;Cytogenetics;cytokine;Data;data integrity;data management;Dependence;Disease;DNA Sequence Alteration;DNA sequencing;experimental study;Gene Expression;Gene Expression Profiling;Genetic;genomic profiling;Genomics;Goals;Histopathology;Infrastructure;innovation;insight;Maintenance;Myelofibrosis;Myeloproliferative disease;new therapeutic target;novel marker;novel therapeutic intervention;Pathogenesis;Pathway interactions;Patients;preclinical study;prospective;Reaction Time;repository;Reproducibility;Research;resistance mechanism;responders and non-responders;Sampling;Serum;Somatic Mutation;Specimen;stem;stem cells;targeted treatment;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Therapeutic Trials;Tissue Banks;tool;transcriptome sequencing;Treatment Efficacy;treatment responders;Work

PROJECT_TITLE: Core D: Biomarker and Bio-Informatics Core


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: Parkinson’s disease (PD) is the fastest growing disorder of the nervous system and affects about 110,000 Veterans. Genetic studies have provided vast quantities of data that will be used to better diagnose and treat PD, but most of them have been done in people of European ancestry. The problem is that some of the results cannot be generalized to people of other ancestries who might not be able to benefit as much from the advances in treatment this information will provide. This project will address that disparity by examining the genetics of PD in African American and Latino Veterans in the Million Veteran Program (MVP) and the Veterans Parkinson’s Disease Genetics Initiative (Vet-PD). We suspect that some genes have a larger influence on the risk of developing PD in these two groups than in people of European origin. Finding these genes will provide researchers with even more opportunities to learn about the causes of PD and ultimately allow clinicians to make better decisions about treatment based on a person’s genetic profile.

PI_NAMEs: ZABETIAN, CYRUS P (contact)

PROJECT_TERMS: Address;admixture mapping;Affect;African;African American;African American population;African ancestry;American;analysis pipeline;Area;Bioinformatics;Caregivers;case control;causal variant;Chromatin;Chromosome Mapping;Clinical;clinical care;clinical decision-making;clinical movement disorder;cohort;Collaborations;Custom;Data;Data Set;design;detection method;Diagnosis;Disease;disorder risk;Disparity;Distress;Equilibrium;Equity;European;European ancestry;Event;Exclusion;Exhibits;experience;Family;Functional disorder;Future;gene discovery;Gene Frequency;Genes;Genetic;genetic architecture;Genetic Diseases;genetic information;Genetic Research;genetic risk factor;Genetic study;Genome;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genomics;Genotype;Goals;human data;Human Genetics;Human Genome Diversity Project;improved;Individual;Inherited;Intervention;Knowledge;Label;Latin American;Latino;Latino Population;Learning;Maps;Methods;Minor;Minority Groups;minority health disparity;Modeling;Molecular;Molecular Genetics;mortality;Movement Disorders;Nervous System Disorder;Neurodegenerative Disorders;Neuronal Injury;novel;Nursing Homes;pandemic disease;Parkinson Disease;Participant;Pattern;Performance;Persons;Phase;Phenotype;polygenic risk score;Population;Population Genetics;Positioning Attribute;precision medicine;Prevalence;Process;programs;Publishing;Quality of life;Quantitative Trait Loci;rare variant;Research;Research Personnel;Resolution;Resources;Risk;risk stratification;Role;Sampling;Signal Transduction;skills;Subgroup;Susceptibility Gene;symptom treatment;targeted treatment;Techniques;Testing;Therapeutic Intervention;trait;Trans-Omics for Precision Medicine;trend;Variant;Veterans;whole genome;Work

PROJECT_TITLE: Genetic Architecture of Parkinson's Disease in African-American and Latino Veterans


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Acute Interstitial Nephritis (AIN) is an important cause of kidney dysfunction, and can lead to chronic kidney disease in many patients. We know that AIN occurs as an immune response in the kidney to certain drugs or infections, but do not have a clear understanding of the cell sources of the inflammation or the tubular and vascular responses. This proposal is designed to define these immune events in human kidney biopsy samples left over after clinical diagnosis has been completed, and to determine how they relate to the development of chronic kidney disease.

PI_NAMEs: CANTLEY, LLOYD G (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3-Dimensional;Acute;Acute Renal Failure with Renal Papillary Necrosis;adjudication;Adrenal Cortex Hormones;Adult;adverse event risk;Affect;Animal Model;Antibiotics;Antibodies;Antigens;Autoimmune Diseases;biobank;Biopsy;Biopsy Specimen;Blood;Blood Vessels;CD4 Positive T Lymphocytes;Cell Communication;cell type;Cells;Characteristics;Chronic Kidney Failure;Clinical;Clinical Data;clinical diagnosis;cohort;Cohort Studies;cytokine;Cytometry;Data;Delayed Hypersensitivity;design;Development;Diagnosis;Drug Exposure;eosinophil;Evaluation;Event;exhaust;Exhibits;Fibrosis;Formalin;Health;Helper-Inducer T-Lymphocyte;Histologic;Human;Image;Imaging Techniques;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunity;improved;Infection;Infiltration;Inflammation;Inflammation Mediators;injured;Injury;Interleukin-5;Interleukin-9;Interstitial Nephritis;Intervention;Kidney;kidney biopsy;kidney dysfunction;Lead;Left;Libraries;Location;Lung;Machine Learning;Malignant Neoplasms;mast cell;Mediating;multiphoton imaging;Neighborhoods;new therapeutic target;novel;Optics;Organ;Paraffin Embedding;Participant;Pathogenesis;Pathogenicity;Pathologic;Patients;Pharmaceutical Preparations;Play;preservation;prevent;Prognosis;Protocols documentation;Proton Pump Inhibitors;Quantitative Evaluations;Reaction;Recovery;Recovery of Function;renal damage;Renal function;response;Role;Sampling;single-cell RNA sequencing;Site;Skin;Source;Steroids;targeted treatment;Techniques;Testing;Tissue Preservation;Tissues;Toxic effect;Tubular formation;Universities;Urine;Validation;vascular injury;Virus Diseases;Withdrawal

PROJECT_TITLE: Defining the Pathogenesis and Prognosis of Human Acute Interstitial Nephritis

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: GAINESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Natural products are the best source of drugs and drug leads and terpenoids, the largest family of natural products, have a wide range of clinically important activities including antibiotic, anticancer, antimalarial, and immunosuppressant properties. The proposed studies will lead to the discovery of new natural products with important biological activities, facilitate future discovery efforts by the development of systems dedicated to facile identification of terpenoids in bacteria, and result in the characterization of natural product biosynthetic enzymes. A greater understanding of terpenoid biosynthesis will also provide insights into how nature constructs medicinally relevant compounds and how these enzymes may be used as tools for future discoveries in biochemistry, bioengineering, and drug development.

PI_NAMEs: RUDOLF, JEFFREY DANIEL (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Actinobacteria class;Address;Anabolism;anti-cancer;Anti-malarials;Antibiotics;Bacteria;Bacterial natural products;Biochemistry;Bioinformatics;Biological;Biomedical Engineering;Biotechnology;Chemicals;Clinical;Collaborations;combinatorial;Complex;Cyclization;Cytochrome P450;Dedications;Development;drug development;drug discovery;Engineering;Enzymatic Biochemistry;Enzymes;experience;Family;Future;Gene Cluster;Genome;Genomics;Immunosuppressive Agents;In Vitro;in vivo;innovation;insight;interdisciplinary approach;Libraries;Medicine;metabolomics;Methodology;Mining;Natural Product Drug;Natural Products;Nature;novel;novel therapeutics;Outcomes Research;Pathway interactions;Pharmaceutical Preparations;programs;Property;Proteins;Research;small molecule;Source;Structure-Activity Relationship;success;synthetic biology;Systems Development;terpene synthase;Terpenes;Terpenoid Biosynthesis Pathway;tool;Up-Regulation;X-Ray Crystallography

PROJECT_TITLE: Discovery and Biosynthesis of Bacterial Terpenoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Networking and Information Technology R&D (NITRD);Women's Health Research

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There remains an important need for the development of effective and safe methods for accurate diagnosis of breast cancer and its subsequent management. Optoacoustic tomography (OAT) has great potential to circumvent the limitations of existing breast imaging modalities but, currently, there is no validated OAT method that is sufficiently accurate for widespread clinical imaging. The proposed research will establish computational tools for performing virtual imaging trials that can inform and accelerate the development of clinically viable and effective 3D breast OAT technologies.

PI_NAMEs: ANASTASIO, MARK A (contact)

PROGRAM_OFFICER_NAME: SHABESTARI, BEHROUZ

PROJECT_TERMS: 3-Dimensional;Acceleration;accurate diagnosis;Acoustics;Anatomy;angiogenesis;Blood;Breast;breast cancer diagnosis;breast imaging;Breast Magnetic Resonance Imaging;cancer imaging;Clinic;Clinical;clinical development;clinical imaging;Clinical Trials;Communities;computer framework;Computer Models;computerized tools;Computing Methodologies;Consumption;cost;cost efficient;Coupled;Data;data acquisition;density;design;Detection;Development;diffuse optical tomography;Ethics;experimental study;Future;Generations;Goals;Hemoglobin;Human;Hypoxia;Image;image reconstruction;imager;imaging modality;imaging study;in silico;interest;Ionizing radiation;Knowledge;Lesion;Light;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Ultrasonography;Mammography;Measurement;Measures;Metabolic;Metabolism;Methods;Modality;Modeling;non-invasive imaging;novel;open source;Optics;optoacoustic tomography;Oxygen;Pathologic;Physics;Physiological;Play;Probability;Process;Property;public health relevance;quantitative imaging;reconstruction;Research;Research Personnel;Resolution;Roentgen Rays;Role;simulation;System;Techniques;Technology;Time;Tissue imaging;Tissues;tool;Translating;Translations;tumor;tumor growth;tumor progression;virtual imaging;X-Ray Computed Tomography

PROJECT_TITLE: A Computational Framework Enabling Virtual Imaging Trials of 3D Quantitative Optoacoustic Tomography Breast Imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Neck Pain;Pain Research;Physical Activity

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Chronic neck pain ranks in the top five causes for years lived with disability. To inform the feasibility and design of a future definitive trial, the goal of this application is to perform a pilot study of chiropractic care and Tai Chi mind-body exercise for adults with chronic non-specific neck pain.

PI_NAMEs: WAYNE, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Activities of Daily Living;Address;Adult;Area;arm;Awareness;Biological Factors;Biomechanics;biopsychosocial;Boston;Caring;Chiropractor;chiropracty;Chronic;Chronic neck pain;chronic pain management;chronic painful condition;Clinical;Clinical Management;cognitive process;cognitive skill;Communities;Complement;Complementary Health;Complex;Data Collection;design;Diagnosis;disability;Disease Management;Educational Materials;Educational process of instructing;effectiveness evaluation;Etiology;evidence base;Exercise;exercise prescription;flexibility;functional disability;Functional disorder;Funding;Future;Goals;Health Care Costs;Health Personnel;improved;Individual;instructor;Integrative Medicine;Interoception;Intervention;Interview;Kinesthesis;Learning;Lifting;Low Back Pain;Manuals;Mediating;Methods;Migraine;mind/body;mindfulness;Modality;Monitor;Movement;multi-component intervention;multimodality;Musculoskeletal;National Center for Complementary and Integrative Health;Neck;Neck Pain;Nonpharmacologic Therapy;Outcome;Pain;Pain management;pain reduction;Participant;Pathology;Patients;Pattern;Persons;pharmacologic;Pilot Projects;Posture;Prevalence;Procedures;productivity loss;Protocols documentation;Provider;psychologic;Psychological Factors;Public Health;Quality of life;Randomized;recruit;Reporting;Research;rumination;Safety;Self Efficacy;Self Management;Severities;Site;skills training;social factors;Spinal Manipulation;Strategic Planning;Structure;study population;systematic review;Tai Ji;Techniques;Therapeutic;three-arm trial;Training;treatment as usual;trial comparing;Visit;Waiting Lists;Walking;Work;years lived with disability;years of life lost to disability

PROJECT_TITLE: Combined Chiropractic Care and Tai Chi for Chronic Non-Specific Neck Pain


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Recovery Support Services;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it seeks to reduce opioid-related health inequities experienced by American Indians and Alaska Natives. It would do this by characterizing opioid use disorder systems of care and barriers and facilitators to care. This project is relevant to NIH’s mission because it would generate knowledge to reduce opioid-related morbidity and mortality (e.g., overdose deaths) by developing optimal opioid use disorder treatment implementation strategies in the context of Tribal Nations.

PI_NAMEs: GREENFIELD, BRENNA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Address;Advocacy;Affect;Alaska Native;American Indian community;American Indians;Buprenorphine;Capital;care systems;Caring;Clinic;Clinical;Communities;community based participatory research;Complement;Consolidated Framework for Implementation Research;Consultations;County;Data;Data Collection;Death Rate;Dissemination and Implementation;Drug Addiction;Drug Prescriptions;evidence base;experience;Family;Funding;Goals;Grant;health inequalities;Heroin;implementation strategy;improved;Individual;innovation;Intake;Interview;Joints;Knowledge;lens;long term recovery;Measures;medical schools;medication-assisted treatment;Minnesota;Mission;Morbidity - disease rate;mortality;natives;Opiate Addiction;Opioid;opioid epidemic;opioid mortality;opioid use disorder;Outcome;Outcomes Research;Outpatients;overdose death;Personal Satisfaction;Pharmaceutical Preparations;Phase;Pilot Projects;prospective;Protocols documentation;Public Health;public health emergency;Recovery;Recovery Support;reduced substance use;relapse prevention;Research;Research Methodology;reservation-based;response;Rural;Services;social;Source;standard of care;State Government;substance use;tool;treatment optimization;treatment program;tribal community;tribal Nation;Tribes;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;Universities;uptake;White Earth;Work

PROJECT_TITLE: Changing our paths: Well-being and recovery among American Indians with opioid use disorder


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: NARRATIVE In the first cycle of this grant, we found that a protein belonging to a novel and currently untapped class of drug targets is present at high levels in cells lining the joints of rheumatoid arthritis patients, where it promotes the aggressive behavior of these cells in joint inflammation and destruction. The objective of this renewal application is to better understand the role and regulation of this protein in rheumatoid arthritis. The long-term goal is to design novel therapeutics against this protein to help control rheumatoid arthritis in patients non-responsive to current therapies.

PI_NAMEs: BOTTINI, NUNZIO  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Aggressive behavior;Anti-Rheumatic Agents;Arthritis;arthritis therapy;Binding;Biochemical;Biological Assay;Biology;cell behavior;Cell Line;cell motility;Cells;Cellular biology;Clinic;Coculture Techniques;Cytoskeletal Proteins;Cytoskeleton;Data;Degenerative polyarthritis;design;Development;Dimerization;Disease;Disease remission;disorder control;Drug Targeting;Electrons;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;extracellular;Extracellular Domain;ezrin;Fibroblasts;Funding;Genes;Genetic Transcription;Glycosaminoglycans;Goals;Grant;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Human;Immune;Immunoglobulin Domain;immunoregulation;Immunosuppressive Agents;imprint;In Vitro;in vivo;Incubated;Inflammation;innovation;interest;Invaded;joint destruction;joint inflammation;joint injury;Joints;Knowledge;Lead;Mediating;Membrane;Microscopy;migration;Molecular;Morbidity - disease rate;mouse model;Mus;Nature;neutrophil;novel;novel therapeutics;overexpression;Pathway interactions;Patients;Pattern;Permeability;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Play;polysulfated glycosaminoglycan;Protein Dephosphorylation;protein expression;Protein Family;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Proteoglycan;Publishing;recruit;Regulation;Reporting;Rheumatoid Arthritis;Role;Series;Side;Signal Transduction Inhibition;structural biology;Surface;Swelling;syndecan-4;Synovial Membrane;Therapeutic;Therapeutic Agents;therapeutic target;TNF gene;Translating;Validation;Work

PROJECT_TITLE: Role of PTPRS in Rheumatoid Arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Health Services;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse;Telehealth

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The primary goal of the CIFASD Consortium Diagnostic-Telemedicine Resource is to ensure consistent and accurate diagnoses of children and adults with fetal alcohol spectrum disorders (FASD) at study sites throughout the world. Because there is a critical shortage of health care practitioners who have the expertise to make this diagnosis, the Diagnostic-Telemedicine Resource will train new practitioners using telemedicine, aided by novel eHealth tools to perform these examinations. Finally, we will test these methods in delivering diagnostic services for FASD to remote areas of Alaska.

PI_NAMEs: DEL CAMPO CASANELLES, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;Address;Adult;Alaska;Alcohols;Algorithms;Area;Brain;Characteristics;Child;Clinic;Clinical;Collaborations;Communities;Complement;Computers;cost;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Diagnostic Services;disease classification;Dysmorphology;Early Intervention;effectiveness evaluation;eHealth;Ensure;Evaluation;Face;Failure;feature detection;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal diagnosis;Funding;Genes;geographic barrier;Goals;Health Personnel;health training;Healthcare;Image;Improve Access;improved;Individual;Intervention;Life;Live Birth;Measurement;Methods;Modality;Monitor;novel;Patient Recruitments;Persons;Physical assessment;prenatal;Probability;Provider;Public Health;Research;Research Personnel;Resources;Sampling;screening;Services;Site;smartphone application;Standardization;Syndrome;Telemedicine;Testing;tool;Training;Trees;Work

PROJECT_TITLE: FASD Diagnostic Telemedicine Resource


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Pediatric

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Hormonal systems regulate key physiologic processes in virtually all organ systems, and are especially important for growth and development, reproduction, and carbohydrate homeostasis; these are areas addressed by Pediatric Endocrinology. Well-trained Pediatric Endocrine investigators in basic, translational, and clinical research are needed to advance this complex and rapidly developing field, to better understand normal physiology and associated disorders. This proposal seeks continued funding for one of the oldest and most successful Pediatric Endocrine Fellowship Training Programs, with the aim of continuing to produce the next generation of academic leaders and mentors in this field.

PI_NAMEs: GITELMAN, STEPHEN E (contact);WONG, JENISE C

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Training Program in Pediatric Endocrinology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE & PUBLIC HEALTH RELEVENCE This proposal aims to elucidate how peripheral sensory systems alter nicotine aversion neurocircuitry and ultimately regulate nicotine intake using mouse models and various genetic approaches. The existence of this ‘bottom-up’ regulation of nicotine intake by the nodose ganglia could prove extremely useful for the development of novel addiction therapies for two reasons: first, direct electrical stimulation of this ganglia has already been validated as a treatment for other neurological disorders, and second, nodose activity can be altered by non- invasive means either via systemic drug administration that targets the organ systems that it innervates or lifestyle changes such as diet and exercise.

PI_NAMEs: BRAUNSCHEIDEL, KEVIN  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Ablation;addiction;Afferent Neurons;Agonist;Applications Grants;Behavior;Bioinformatics;Biological Process;blood-brain barrier crossing;Body System;Brain;Brain region;Breeding;C57BL/6 Mouse;Cardiovascular Diseases;career;Catheters;Cessation of life;Cholecystokinin;Cholecystokinin Receptor;Cigarette Smoker;cigarette smoking;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;computer program;Consummatory Behavior;cost;CRISPR/Cas technology;Data;Development;diet and exercise;differential expression;Disabled Persons;Dissection;Dose;Electric Stimulation;Emerging Technologies;Esthesia;experience;Fiber;Food;Ganglia;ganglion cell;Gastrointestinal Diseases;Genes;Genetic;genetic approach;Genetic Transcription;genome editing;Genomics;Habenula;Habits;Healthcare;Heart;hindbrain;Human;Immune System Diseases;Implant;in vivo;Infusion procedures;Inhalation;Injections;innovation;Intake;interpeduncular nucleus;Intravenous;intravenous administration;Investigation;knock-down;Laboratories;Learning;Lesion;Life Style;Literature;Lung;Maintenance;Mastication;Medial;Mediating;Mentors;mind body interaction;Morbidity - disease rate;mortality;Motivation;mouse genetics;mouse model;multidisciplinary;Mus;Nervous System Disorder;neural;neural circuit;Neurons;neuropsychiatric disorder;Nicotine;Nicotine Dependence;nicotine self-administration;nicotine use;Nicotinic Agonists;Nicotinic Receptors;Nodose Ganglion;novel;Nucleus solitarius;Operative Surgical Procedures;Organ;Pattern;Peptides;Peripheral;Pharmaceutical Preparations;Pharmacologic Actions;Plasma;Play;Population;Positioning Attribute;premature;Property;Public Health;rapid growth;receptor;Recording of previous events;Relapse;Research;Research Personnel;Respiration Disorders;response;Rewards;Risk;Rodent;Role;Satiation;Self Administration;Self Assessment;Sensory;sensory input;sensory system;Signal Pathway;Signal Transduction;Sincalide;single cell sequencing;single-cell RNA sequencing;Site;Smoker;System;Technical Expertise;Technology;Testing;Tobacco;tobacco control;Tobacco Dependence;Tobacco smoke;tobacco smokers;Tobacco use;tool;Training;transmission process;United States;Up-Regulation;Vagus nerve structure;Virus

PROJECT_TITLE: Nicotine & Nodose: A Neural Basis for Peripheral Control over Nicotine Intake


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_DEPT: SURGERY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Controversies about the contributions of epithelial to mesenchymal transition (EMT) mechanism in tumor metastasis and chemoresistance have been discussed for decades. Given the transient, reversible and dynamic natures of the EMT process, we propose to employ multiple lineage-tracing models to study the roles of EMT in metastasis and chemoresistance. Resolving the controversies in the field will not only improve our mechanistic understanding of tumor metastasis but also provide novel targets/opportunities in combatting the deadly disease.

PI_NAMEs: GAO, DINGCHENG  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Apoptosis;Bar Codes;Blood;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;BT 474;CCL7 gene;Cell Line;Cells;Chemoresistance;chemotherapy;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;CRISPR/Cas technology;Development;Disease;E-Cadherin;Embryonic Development;epithelial to mesenchymal transition;Epithelium;Event;Exhibits;Fluorescence;Genetic;Genetic Markers;Homing;Human;improved;in vivo;Individual;Invaded;Knock-in;Lung;MDA MB 231;Mediating;Mesenchymal;Mesenchymal Cell Neoplasm;Metastatic Neoplasm to the Lung;migration;Modeling;Mouse Mammary Tumor Virus;Mus;Nature;Neoplasm Metastasis;neoplastic cell;novel;Phenotype;polyoma middle tumor antigen;Primary Neoplasm;Process;programs;Property;Recurrence;Reporter;Reporting;Resistance;Role;Site;Snails;stemness;transcription factor;transdifferentiation;Transgenic Mice;tumor;tumor progression;Vimentin

PROJECT_TITLE: To study the EMT contributions in tumor metastasis and chemoresistance by using lineage tracing models

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Pediatric oncology lags behind adult cancers with respect to the availability of targeted therapies. Expanding and accelerating treatment options for pediatric cancers to improve outcomes and to satisfy the requirements of the Research to Accelerate Cures and Equity (RACE) for Children Act is a central goal for NCI's Pediatric In Vivo Testing Program (Ped-In Vivo-TP). We will establish the Pediatric In Vivo Testing Coordinating Center (PIVOT CC) to manage a comprehensive and cohesive testing program to advance precision medicine in pediatric oncology through effective public-private partnerships among pharmaceutical companies, regulatory agencies, funders, and research organizations.

PI_NAMEs: BULT, CAROL J (contact);CHUANG, JEFFREY HSU-MIN

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Address;Adult;Antineoplastic Agents;Bioinformatics;Biological Models;cancer genomics;Cancer Model;Cancer Patient;cancer therapy;Child;Childhood;Clinical;Clinical Trials;cloud based;Collaborations;Communication;Communities;Data;Data Analyses;data integrity;data management;data portal;Data Security;data sharing;Database Management Systems;Databases;Decision Making;Development;efficacy evaluation;Engineering;Ensure;Equity;experience;FDA approved;Foundations;Generations;Genomics;genomics cloud;Goals;human cancer mouse model;improved outcome;in vivo;in vivo evaluation;in vivo Model;Institution;International;Laboratories;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;member;metadata standards;Methods;model development;Molecular Target;New Agents;new therapeutic target;novel therapeutics;Online Systems;patient derived xenograft model;Pediatric Oncology;pediatric patients;Performance;Pharmacologic Substance;Pharmacology;precision medicine;preclinical study;Preclinical Testing;Process;Productivity;Program Evaluation;programs;Property;Protocols documentation;public-private partnership;Publications;Recording of previous events;Research;Research Personnel;Resource Development;Resource Informatics;Resources;Secure;Site;software systems;Standardization;Statutes and Laws;success;System;Systems Analysis;targeted cancer therapy;targeted treatment;technical report;Testing;The Jackson Laboratory;Therapeutic Agents;Time;user-friendly;Vision;web page

PROJECT_TITLE: Pediatric Oncology In Vivo Testing Program Coordinating Center


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Diabetes;Genetics;Nutrition;Prevention;Women's Health Research

PHR: Project Narrative Metastasis is the main cause of fatality from breast cancer which is further aggravated by diabetes and understanding the molecular basis of this process and targeting key players that promote it is likely to lead to better therapeutic options. To achieve this goal, we developed a potent inhibitor of ARK5 and CDK4 (proteins that drive breast tumor growth) (ON123300), which was very effective in inhibiting tumor cell growth in diabetic models. Here, we propose to examine the mechanism of action and utility of ON123300 as a therapeutic agent for high-risk breast cancers using a diabetic mouse model and in mouse models of high-risk breast cancer generated from patient tumor tissues (PDX models).

PI_NAMEs: REDDY, E PREMKUMAR (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Affinity;Affinity Chromatography;Apoptotic;Binding;Biological Models;blood glucose regulation;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer therapy;Cancer Cell Growth;Cancer Etiology;CDK4 gene;Cell Cycle;Cell Death;cell growth;Cell Proliferation;Cells;Cellular Metabolic Process;Chemoresistance;Clinical Trials;comparison control;Cyclin-Dependent Kinase Inhibitor 2A;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diet;Disseminated Malignant Neoplasm;Drosophila genus;effective therapy;epidemiology study;ERBB2 gene;Exhibits;Family;fasting blood glucose level;Female;gain of function;Gene Family;Genes;glucose metabolism;glucose tolerance;Glycogen;Goals;Growth;High Fat Diet;high risk;Hyperglycemia;Hyperinsulinism;Incubated;inhibitor;insulin regulation;Insulin Resistance;insulin sensitivity;insulin signaling;kinase inhibitor;knock-down;Knockout Mice;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mass Spectrum Analysis;Metabolic Pathway;Metabolism;Methods;Modeling;Molecular;mortality;Mouse Mammary Tumor Virus;mouse model;Mus;Muscle;Nature;Neoplasm Metastasis;neoplastic cell;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;NUAK1 gene;Oncogenes;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phenotype;Phosphotransferases;Physiological;Play;Prediabetes syndrome;Predisposition;Process;Prognosis;Proliferating;Property;Proteins;ras Oncogene;Recurrent tumor;Relapse;Resistance;Resistance development;resistance mechanism;Risk;Role;Signal Pathway;small molecule;small molecule inhibitor;sugar;targeted treatment;Technology;Testing;theories;Therapeutic;Therapeutic Agents;therapeutically effective;Translating;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Tumor Tissue;tumor xenograft;Whole Organism;Woman;Women's mortality;Wood material;Work

PROJECT_TITLE: Targeting cell cycle and metabolic pathways of high risk breast cancers using mouse models of hyperinsulinemia

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Few people realize that environmental pollution and some behaviors like physical activity and tobacco smoking can affect their health by “turning on” or “turning off” certain genes through a process called “epigenetic modification.” This study will develop and test strategies for communicating about epigenetics that are understandable to people from different social and demographic groups, and that do not promote stigma, discrimination, or other harmful beliefs.

PI_NAMEs: WATERS, ERIKA A (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Affect;American Indians;Asian;Basic Science;Behavior;Belief;Biomedical Research;Black race;Cell division;Chemicals;Clinical;clinical application;clinical practice;clinical translation;Clinical Trials;college;Communication;design;Development;disadvantaged background;Discrimination;Disease;DNA;Education;Environmental Exposure;Environmental Pollutants;Environmental Pollution;Environmental Risk Factor;Epigenetic Process;epigenomics;Equity;essentialism;ethical, legal, and social implication;Ethnic Origin;Ethnic Population;experience;experimental study;Exposure to;Focus Groups;Fostering;Foundations;Gene Expression;General Population;Generations;Genes;Genetic;genetic approach;Genetic Code;Genetic Determinism;Genomics;grandchild;Health;health care availability;health care disparity;health disparity;health inequalities;Hispanic;Inequity;Inherited;Knowledge;Life Style;Link;marginalization;marginalized population;Mass Media;member;Methods;Misinformation;Modification;Molecular;Native Hawaiian or Other Pacific Islander;news;Not Hispanic or Latino;novel therapeutics;Participant;perceived discrimination;Perception;Persons;Phase;Physical activity;Population;population based;practical application;prevent;Process;Public Health Practice;Race;racial population;racism;Research;Research Personnel;Risk;Sampling;Shapes;social;social media;social stigma;social stress;sociodemographics;Stigmatization;Surveys;Technology;Testing;Therapeutic;therapeutic target;Time;Tobacco smoking behavior;Translating;Translation Process;Translations;Underrepresented Populations;Underserved Population;uptake

PROJECT_TITLE: Investigating ELSI issues that may facilitate or impede clinical translation of epigenomic research


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Human intestinal organoids (HIOs) represent an excellent in vitro model of the human intestine and a promising source for intestinal tissue repair therapies. However, the HIO in vitro differentiation process is limited by low yield of organoids, while the therapeutic translatability is hampered by a lack of clinically-relevant delivery materials. This project will result in a well-defined engineered synthetic matrix to guide the HIO in vitro differentiation process and in vivo delivery, increasing the clinical relevance of the HIO transformative therapeutic potential.

PI_NAMEs: MULERO-RUSSE, ADRIANA  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: 3-Dimensional;Address;Adhesives;Adult;Affect;American;Architecture;Area;arm;Basement membrane;Biochemical;Biocompatible Materials;Biological Products;Biophysics;Cell Therapy;cell type;Cells;Cellular Structures;Chemical Injury;clinical translation;clinically relevant;Confocal Microscopy;Cues;delivery vehicle;density;Dependence;Development;Diameter;differentiation in vitro;directed differentiation;disease model;Drug Screening;Elasticity;Encapsulated;Endoderm;Engineering;Engraftment;Epithelial Cells;epithelial repair;epithelial wound;Epithelium;ethylene glycol;experience;Extracellular Matrix;Fiber Optics;Formulation;Foundations;Gene Expression Profile;Generations;Growth;Growth Factor;healing;Hindgut;Human;human pluripotent stem cell;human stem cells;Hydrogels;immunodeficiency;In Situ;In Vitro;in vitro Model;in vivo;Inflammation;Inflammatory Bowel Diseases;inflammatory milieu;injured;innovation;insight;intestinal crypt;intestinal epithelium;intestinal injury;Intestinal permeability;Intestines;Knowledge;Length;Ligands;Maleimides;matrigel;Measures;Mechanics;Membrane;Mesenchymal;microbiota;monolayer;Mus;nutrient absorption;Organoids;Patients;polarized cell;Polymers;Process;process repeatability;programs;Proliferating;Property;Rattus;Recovery;repaired;Reproducibility;Research;Resolution;self organization;Small Intestines;Source;Specific qualifier value;spheroids;stem cells;Structure;Technology;Therapeutic;Time;tissue repair;Tissues;tool;translational potential;Tube;Tumor-Derived;Ultraviolet Rays;Work;wound;wound healing

PROJECT_TITLE: F31 Mulero Russe


PHR: Project Narrative Obesity is a major public health concern as it increases the risk for a number of common diseases such as type 2 diabetes, heart disease, stroke and certain forms of cancer. Obesity results from the interaction of the environment with a genetic predisposition and large-scale efforts have recently pointed at regions in the human genome in which genetic variations predispose humans to obesity. Our studies are aimed at determining how these genetic variations are involved in obesity and how this knowledge could be harvested for new obesity treatments.

PI_NAMEs: AHITUV, NADAV ;VAISSE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Address;Affect;Anatomy;ATAC-seq;Biological Assay;Body Weight;cancer type;candidate identification;Cause of Death;Central Nervous System;ChIP-seq;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;CRISPR-mediated transcriptional activation;differential expression;Disease;Eating;Elements;Environment;Family Study;Food Intake Regulation;Gene Expression;Genes;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genome;genome wide association study;Genomics;Harvest;Heart Diseases;Heritability;High Fat Diet;Homeostasis;Human;Human Genome;Hypertension;Hypothalamic structure;in vivo;indexing;Injections;Knowledge;Laboratories;Link;Malignant Neoplasms;Maps;Metabolic;Modeling;Mus;Myocardial Infarction;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acid Regulatory Sequences;Obesity;obesity treatment;Phenotype;Population;Protocols documentation;Public Health;Recombinant adeno-associated virus (rAAV);Regulation;Regulatory Element;Resources;Risk;Role;Single Nucleotide Polymorphism;Stroke;Technology;Testing;Therapeutic;therapeutic evaluation;therapeutic target;transcriptome;transcriptome sequencing;Twin Studies;Untranslated RNA;Variant;Weight;Weight Gain;Work

PROJECT_TITLE: From Obesity GWAS to therapeutic targets

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ORG_CITY: SANTA BARBARA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative: Peroxisomes are ubiquitous, membrane-bound organelles that cells use to compartmentalize specialized metabolic reactions. Loss of peroxisome function causes Peroxisome Biogenesis Disorders, characterized by hearing and vision loss, neurodegeneration, and liver, kidney, and bone disease. This research seeks to understand the molecular mechanisms underlying the formation of maintenance of peroxisomes and the consequence to the cell when these mechanisms go awry.

PI_NAMEs: GARDNER, BROOKE MEGHAN (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: Investigating the mechanisms of peroxisome homeostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: OVERALL: PROJECT NARRATIVE The Alvin J. Siteman Cancer Center (SCC) at Washington University and Barnes-Jewish Hospital is a NCI designated Comprehensive Cancer Center whose mission is to prevent cancer in the community and transform cancer patient care through scientific discovery. SCC accomplishes this mission through strong research programs, shared resource support, education and training, pilot funding programs, and community outreach. The translational research and scientific discovery facilitated by our seven multidisciplinary research programs and 10 shared resources (11th requested in this application) is driven by the needs of patients in our 82-county catchment area throughout Missouri and southern lllinois.

PI_NAMEs: EBERLEIN, TIMOTHY J (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: anti-cancer research;Area;bench to bedside;burden of illness;Cancer Biology;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer imaging;Cancer Patient;cancer therapy;Catchment Area;clinical care;Clinical Trials;Collaborations;Communities;Community Outreach;community partnership;Comprehensive Cancer Center;County;Data;Development;disparity reduction;Diverse Workforce;Exclusion;follower of religion Jewish;Funding;Genomics;Grant;Health Services Accessibility;Hematopoietic;Hospitals;Illinois;imaging science;Imaging technology;Immunology;Immunotherapy;implementation science;Incidence;innovation;Institution;Interdisciplinary Study;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;member;Methods;Mission;Missouri;Molecular;mortality;multidisciplinary;Neoplasm Metastasis;novel;Pathway interactions;Patient Care;patient population;Patients;personalized medicine;prevent;Prevention;Prevention strategy;programs;Publications;Regional Cancer;Research;Research Personnel;Resource Sharing;Risk Factors;Risk Reduction;Schools;Science;Screening for cancer;Solid Neoplasm;Speed;Strategic Planning;success;Talents;Therapeutic;Time;Tissues;Training and Education;Translating;Translational Research;tumor immunology;tumor progression;Underserved Population;Universities;Washington

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Accounting;anti-cancer research;Area;Award;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;community engagement;Community Outreach;Contracts;Counseling;Development;Endowment;Ensure;expectation;experience;Faculty;follower of religion Jewish;Funding;Funding Opportunities;Goals;Grant;Hospitals;Individual;Informatics;Infrastructure;Institution;Institutional Review Boards;Investments;Knowledge;Leadership;Marketing;medical schools;member;NCI Center for Cancer Research;Oncology;oncology service;operation;outreach;Parents;Problem Solving;Process;programs;recruit;Reporting;Research;research and development;Research Personnel;Resource Sharing;Resources;Services;Strategic Planning;Talents;Technology;Training and Education;Universities;Vision;Washington;working group

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

PHR: There is urgent need to reach justice-involved women for life-saving, evidence-based PrEP and medications for opioid use disorder, using innovative healthcare delivery models that surmount existing social and structural barriers to engagement. We will randomize justice-involved, PrEP- eligible women with opioid use disorder across two sites (Connecticut and Alabama) to receive a PrEP decision aid + eHealth delivery of integrated PrEP/medications for opioid use disorder vs. the decision aid-only. We will evaluate clinical and implementation outcomes important for scalability and sustainability across diverse contexts.

PI_NAMEs: MEYER, JAIMIE  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;AIDS prevention;Alabama;Behavioral;Caring;Clinical;Collaborations;Communities;community collaboration;comorbidity;Connecticut;Continuity of Patient Care;court;COVID-19;Criminal Justice;Decision Aid;design;Diagnosis;Diversion Program;Effectiveness;eHealth;Elements;Eligibility Determination;Enrollment;Epidemic;Epidemiology;evidence base;Focus Groups;Follow-Up Studies;Geography;health care delivery;health disparity;Hepatitis C Therapy;Hepatitis C Transmission;HIV;HIV Infections;HIV risk;implementation barriers;implementation context;implementation determinants;implementation evaluation;implementation outcomes;implementation science;improved;Individual;innovation;Intervention;Interview;Jail;Justice;Life;Measures;medication for opioid use disorder;member;Methods;Modeling;NIH Office of AIDS Research;Opioid;opioid use disorder;Outcome;Output;parole;Patients;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;preference;Prisons;probation;Provider;Public Health;Publishing;Quality-Adjusted Life Years;Randomized;recruit;remote delivery;Research;Research Infrastructure;Resources;Risk;Sampling;scale up;secondary outcome;Service delivery model;Sexually Transmitted Diseases;Site;social;social stigma;Standardization;Stigmatization;Stimulant;stimulant use;Structure;Substance Use Disorder;Supervision;support tools;Surveys;System;Techniques;telehealth;Testing;Time;tool;treatment arm;treatment as usual;unethical;uptake;Woman;Work

PROJECT_TITLE: Integrated eHealth for HIV and Substance Use Disorders in Justice-involved Women


PROJECT_TERMS: Advertising;anti-cancer research;Area;Award;Basic Science;Biomedical Research;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Patient;Cancer Research Project;career;Career Choice;career development;Clinical Research;Communities;community research;Critical Thinking;Data;design;diversity and inclusion;Doctor of Philosophy;Education;education planning;education research;Educational Activities;Educational Status;Educational workshop;Eligibility Determination;Ensure;Environment;Evaluation;experience;Faculty;Foundations;Funding;Funding Agency;Future;Goals;Grant;high school;improved;Individual;Infrastructure;Institution;interest;Knowledge;Leadership;Learning;Malignant Neoplasms;medical schools;medical specialties;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Minority Recruitment;minority trainee;minority undergraduate;Monitor;NCI Center for Cancer Research;Participant;Patient-Focused Outcomes;Patients;Physicians;programs;quality assurance;Recommendation;Recording of previous events;Reporting;Research;research and development;Research Personnel;Research Training;resilience;Resources;Safety;Science;Scientist;skills;Structure;Students;success;symposium;Teacher Professional Development;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;Travel;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Vocational Guidance;Washington;working group;Writing

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Contraception/Reproduction;Dementia;Estrogen;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The brain changes that accompany normal aging and Alzheimer’s disease do not occur at the same time or to the same degree in every part of the brain; instead they show a characteristic pattern in which some regions are affected to a much greater degree than are others. It is not known the extent to which these spatial patterns reflect differences in the local vulnerability between areas, nor the extent that they might reveal a mechanism by which pathology spreads. By measuring - across the entire cortex and cerebellum of aged individuals - the extent of pathological change, the patterns of brain inter connectivity, and local protein expression and metabolism we will test hypotheses about vulnerability and spread of Alzheimer’s pathology, opening the door to protective intervention.

PI_NAMEs: DISNEY, ANITA A (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Age;age related;Age related pathologies;aged;Aging;aging brain;aging population;Aldehydes;Alleles;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;analytical tool;Animal Model;animal old age;Animals;Apolipoproteins;Area;Arginine;Atlases;Biochemical;Biochemical Pathway;Bioinformatics;Biological;Biological Markers;biomarker identification;Blood - brain barrier anatomy;Brain;Brain Diseases;Brain Mapping;Brain region;burden of illness;Cerebellum;Characteristics;Code;Complex;Data;Diagnosis;dimension reduction;Dimensions;Disease;Disease Progression;Early Diagnosis;early screening;Female;Freezing;frontal lobe;Functional Magnetic Resonance Imaging;Genes;Genome;high risk;Histologic;Histology;Human;human model;Individual;Inflammatory;innovation;insight;Intervention;Joints;Late Onset Alzheimer Disease;Link;Liquid Chromatography;Literature;Location;Macaca;Macaca mulatta;male;Maps;mass spectrometric imaging;Measures;Memory impairment;Menopause;metabolome;metabolomics;Methionine;Methods;mild cognitive impairment;Modeling;Monkeys;multidimensional data;neurochemistry;neuropathology;normal aging;novel;novel strategies;Organ;Outcome;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Pattern;Perimenopause;Phase;Positioning Attribute;Postmenopause;pre-clinical;Pre-Clinical Model;preclinical study;Primates;Principal Component Analysis;Process;promote resilience;protein expression;Protein Isoforms;protein metabolism;Proteins;Proteome;Proteomics;Publishing;Purines;Randomized;Research;resilience;Resolution;Risk;Risk Factors;Sampling;Site;small molecule;Statistical Methods;Synapses;tandem mass spectrometry;tau aggregation;tau Proteins;tau-1;Testing;Time;tool;Transgenic Animals;Transgenic Model;Visual Cortex;Visualization

PROJECT_TITLE: A spatially resolved joint cortical metabolome and proteome in aging and menopause for the rhesus macaque


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is one of the most common and serious diseases of childhood, afflicting one in 300 people in North America by 18 years of age and burdening them with a lifelong medical problem. T1D is a complex genetic disease, and to date, most of the mutations that cause or influence it remain unknown. Using new and powerful genetic methodology, we will find scores of mutations that either augment or suppress T1D in mice, yielding new insight into the causes of T1D in human patients and opening the way to specific therapies.

PI_NAMEs: BEUTLER, BRUCE A (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 18 year old;Acceleration;Affect;Alleles;Animals;animation;Apoptotic;Archives;Autoantigens;Autoimmune Diabetes;Autoimmune Diseases;autoreactivity;B-Lymphocytes;Beta Cell;Biological Assay;Blood;Breeding;Cell Count;cell type;Cells;Child;Childhood;Code;Collaborations;Complex;conditional knockout;CRISPR/Cas technology;Cryopreservation;CTLA4 gene;Data;data dissemination;Databases;Date of birth;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;Disease;Disease remission;DNA;DNase-I Footprinting;Documentation;epigenetic regulation;Epitopes;Ethylnitrosourea;Etiology;Exhibits;exome sequencing;Expenditure;Female;forward genetics;Frequencies;Funding;Genes;Genetic;Genetic Diseases;genetic pedigree;Genome;Genomic DNA;Genotype;Germ Lines;Guidelines;Hematopoietic stem cells;Human;Immune;Immune system;Immunologics;Inbred NOD Mice;Inbreeding;Individual;Induced Mutation;Influentials;insight;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;insulitis;Intellectual Property;Ions;Islet Cell;Islets of Langerhans;Knock-out;Laboratories;Light;male;Maps;Measures;Medical;meetings;Meiosis;member;Metabolic;Methodology;Methods;Missense Mutation;Modification;Molecular;molecular sequence database;Monitor;mouse genome;Mus;Mutagenesis;Mutagens;mutant;Mutant Strains Mice;Mutation;N-terminal;Non obese;North America;novel;Nucleotides;Orthologous Gene;Paris, France;Pathogenesis;Pathogenicity;Patients;Penetrance;Peptides;Persons;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Pilot Projects;Point Mutation;Predisposition;prevent;Progress Reports;Protein Overexpression;protein protein interaction;Proteins;Proteomics;Publications;Recovery;Regulatory T-Lymphocyte;Research Design;Resolution;Resource Sharing;response;RNA Splicing;Sampling;screening;Signal Transduction;Site;sperm cryopreservation;Splice-Site Mutation;Stress;success;Sum;T cell receptor repertoire sequencing;T cell response;T-cell receptor repertoire;T-Lymphocyte;Technology;technology platform;Testing;Therapeutic;Thymus Gland;Tissues;transcriptome;transcriptomics;Tumor Necrosis Factor Receptor;United States National Institutes of Health;Untranslated RNA;Work;Writing

PROJECT_TITLE: Modulation of NOD Strain Diabetes by ENU-Induced Mutations


NIH_SPENDING_CATS: Cancer;Immunotherapy;Patient Safety

PROJECT_TERMS: anti-cancer research;Applications Grants;Area;Award;Behavioral;Biological Markers;biomarker discovery;Biometry;Biostatistics Shared Resource;Biotechnology;Cancer Center;Cancer Center Support Grant;cancer immunotherapeutics;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Communities;Comparative Effectiveness Research;Computer software;Computer Systems;Consultations;Data;Data Analyses;Data Collection;data management;Databases;design;Development;Disease;Doctor of Philosophy;early phase clinical trial;Electronic Health Record;Ensure;Evaluation Studies;Faculty;Funding;Futility;genomic data;Goals;Growth;health record;high dimensionality;Immunotherapeutic agent;Infrastructure;innovation;Institution;instructor;Intervention;Investments;Journals;Life Cycle Stages;Malignant Neoplasms;Manuscripts;member;Methodology;Methods;Monitor;Multi-Institutional Clinical Trial;National Cancer Institute;NCI Center for Cancer Research;novel;outreach;patient safety;Peer Review;Persons;Phase;pre-clinical;Precision Medicine Initiative;Preventive;Procedures;Productivity;programs;protocol development;Protocols documentation;Publications;quality assurance;Randomized;recruit;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resource Sharing;Resources;risk prediction;risk stratification;Role;Safety;Sample Size;Science;Services;sound;spatiotemporal;Statistical Data Interpretation;Statistical Methods;student mentoring;Study Section;tool;Toxic effect;Training;Translational Research;Validation

PROJECT_TITLE: Biostatistics Shared Resource


NIH_SPENDING_CATS: Diabetes

PROJECT_TITLE: Core A - Administrative Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Alleles;Animal Model;Area;Automation;base editor;Blood coagulation;Cancer Biology;Cancer cell line;Cancer Center;Cancer Center Support Grant;Cancer Model;CD34 gene;Cell Count;Cell Differentiation process;cell growth;Cell Line;Cell model;cell type;Cells;Characteristics;Chromosomes;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consultations;Cost Savings;CRISPR screen;CRISPR/Cas technology;Data Analyses;Deposition;design;Development;differentiation protocol;Disease;disease model;DNA;Electroporation;Embryo;Engineering;Ensure;Epigenetic Process;ethnic diversity;Ethnic Origin;experience;flexibility;functional genomics;Gene Activation;Gene Silencing;Generations;Genes;Genetic;genetic manipulation;genetic variant;Genome;Genome engineering;genome sequencing;Genomics;Goals;Guide RNA;Hematopoietic stem cells;human embryonic stem cell;improved;induced pluripotent stem cell;interest;Kidney;Libraries;LoxP-flanked allele;Macrophage;Malignant Neoplasms;Mediating;member;Methods;Microinjections;mouse model;Mus;Neoplasm Metastasis;nerve stem cell;Neurons;next generation sequencing;nuclease;Oligonucleotides;Organism;patient derived induced pluripotent stem cells;Patients;Peripheral;Pharmaceutical Preparations;Phase;Physiological;process improvement;programs;Proliferating;Protocols documentation;Publishing;Reagent;repository;Reproducibility;Research Personnel;Resource Sharing;Ribonucleoproteins;Sampling;screening;Services;Short Tandem Repeat;Site;Specificity;Speed;success;Surveys;System;Technology;Testing;Time;timeline;Tissue Expansion;Tissues;tool;treatment response;tumor;tumor growth;Universities;Variant;Washington;Whole Blood;whole genome

PROJECT_TITLE: Genome Engineering and iPSC Center


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE Delivering antiretroviral pre-exposure prophylaxis (PrEP) to people who inject drugs (PWID) through syringe services programs (SSPs), a trusted and well-utilized institution, is acceptable and feasible, yet interventions are needed to support and scale-up the implementation of these services. This randomized controlled trial will assess the effectiveness and cost-effectiveness of an organization-level intervention designed to help SSPs optimize the delivery of PrEP services for PWID.

PI_NAMEs: BAZZI, ANGELA ROBERTSON (contact);LAMBDIN, BARROT HOPKINS;ROTH, ALEXIS MARIE

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Address;AIDS prevention;Anti-Retroviral Agents;Area;Client;Clinical;Consensus;cost;Cost Analysis;cost effectiveness;cost estimate;Country;County;Data;Data Collection;data portal;design;Disease Outbreaks;drug market;Education;Effectiveness;effectiveness evaluation;effectiveness testing;electronic data;Eligibility Determination;Epidemic;Equity;Ethnic Origin;evidence base;Evidence based intervention;Fentanyl;follow-up;Goals;Harm Reduction;health care service utilization;HIV;HIV Seronegativity;Human immunodeficiency virus test;implementation strategy;Improve Access;improved;Incidence;Injecting drug user;Injections;innovation;Institution;Interruption;Intervention;manufacture;Maps;marginalization;Medical;member;Methamphetamine;Modification;Monitor;Naloxone;naloxone dispensing;Needle-Exchange Programs;novel;Outcome;overdose education;Population;Populations at Risk;Positioning Attribute;Poverty;pre-exposure prophylaxis;prevent;prevention service;Prevention strategy;Process;psychostimulant;Race;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Running;scale up;Series;service delivery;Services;sex;Site;social;social stigma;Specialist;System;Systems Analysis;Testing;therapy design;Time;Training;Translating;transmission process;treatment as usual;Trust;uptake;Vulnerable Populations

PROJECT_TITLE: SAIA-PrEP: a systems analysis and improvement approach to optimize PrEP implementation in syringe service programs


NIH_SPENDING_CATS: Diabetes;Genetics

PROJECT_TERMS: Age;Alleles;arm;Attention;Bar Codes;Biological Assay;Blood;Blood capillaries;Breeding;carrier status;causal variant;Cells;Chemistry;Code;Computer software;Computers;Custom;Data;Databases;Detection;Development;Diabetes Mellitus;DNA;electronic data;Ethylnitrosourea;exome sequencing;experience;Failure;Female;Genes;genetic pedigree;Genomic DNA;Genotype;Germ Lines;Glycosuria;Heterozygote;Homozygote;Immune system;Immunologic Tests;Immunologics;Individual;Induced Mutation;Insulin-Dependent Diabetes Mellitus;Ions;Laboratory Personnel;Light;Machine Learning;Maps;Meiosis;Mission;Mus;Mutagenesis;mutant;Mutant Strains Mice;Mutation;Mutation Detection;Nucleotides;paragon;Phenotype;phenotypic data;Process;programs;RNA Splicing;screening;sequencing platform;Site;Software Tools;Splice-Site Mutation;Targeted Resequencing;Technology;Terminology;Training;transmission process;Weaning;Writing

PROJECT_TITLE: Core B - Sequencing, Genotyping and Automated Mapping


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Prevention

PROJECT_TERMS: Acceleration;Accreditation;analytical tool;Area;Artificial Intelligence platform;Basic Science;Bioinformatics;Biological Assay;Biological Markers;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer genomics;Cancer Patient;CLIA certified;Clinical;Clinical and Translational Science Awards;clinical care;clinical sequencing;Collaborations;computational platform;cost effective;Data Analyses;data management;Dedications;design;Development;Diagnostic;disorder prevention;Environment;exome;Experimental Designs;Faculty;Fee-for-Service Plans;fighting;Floor;forest;Genome;Genomics;Goals;Informatics;Infrastructure;innovative technologies;invention;Laboratories;Machine Learning;Malignant Neoplasms;member;Memory;Microarray Analysis;Modeling;Nature;neoantigens;next generation;next generation sequencing;novel;Oncology;operation;Polymerase Chain Reaction;Positioning Attribute;Preparation;Procedures;Program Research Project Grants;Publications;Quality Control;Research;Research Personnel;Resource Sharing;Sampling;Scientist;service providers;Services;Specimen;square foot;structural genomics;Technology;tool;Translations;Universities;vaccine trial;Validation;Vision;Washington;Work

PROJECT_TITLE: Genome Technology Access Center


PROJECT_TERMS: 3-Dimensional;anatomic imaging;anti-cancer research;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Clinical;Clinical Research;Clinical Trials;data exchange;Dedications;Development;Discipline of Nuclear Medicine;Ensure;Evaluation;Functional Imaging;Goals;Image;imaging biomarker;Imaging Device;imaging modality;imaging science;imaging study;improved;Industry;Institution;Laboratories;Magnetic Resonance Imaging;Measurement;Medical center;medical schools;member;Metabolic;molecular imaging;Monitor;National Clinical Trials Network;novel;novel strategies;participant enrollment;Phase;Physicians;Play;Positron-Emission Tomography;Protocol Compliance;protocol development;Qualifying;Quality Control;quantitative imaging;radiologist;Radiology Specialty;Reproducibility;Research;Research Personnel;Resource Sharing;response;Services;Site;Software Tools;Specific qualifier value;success;Therapeutic Intervention;Therapeutic Trials;treatment response;tumor;Tumor Biology;Tumor Markers;Tumor Volume;Universities;Washington;X-Ray Computed Tomography

PROJECT_TITLE: Imaging and Response Assessment Core


PROJECT_TERMS: Alleles;Animal Cancer Model;Antibodies;antibody libraries;Antigens;archive data;Bar Codes;Basic Science;bench to bedside;Biological Assay;Biological Markers;Blood specimen;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;Cancer Vaccines;Categories;CD4 Positive T Lymphocytes;Cells;Clinical;Clinical Investigator;Clinical Trials;Complex;Computers and Advanced Instrumentation;Custom;cytokine;Cytometry;Data;data acquisition;Data Analyses;data archive;data sharing;design;Development;Disease;DNA;Doctor of Philosophy;enzyme linked immunospot assay;Equipment and supply inventories;experience;Experimental Designs;flexibility;Flow Cytometry;fluorophore;follower of religion Jewish;Freezing;Generations;Health Services Accessibility;Heavy Metals;HLA-A gene;Hospitals;Human;Image;Imaging technology;Immune;Immune response;Immunity;Immunoassay;Immunologic Monitoring;Immunologics;Immunology;Immunooncology;Immunophenotyping;Immunotherapy;Institution;instrumentation;International;Investigation;Label;Laboratories;laboratory experience;Laboratory Personnel;Leukapheresis;light microscopy;Malignant Neoplasms;Metals;MHC Class I Genes;MHC Class II Genes;Molecular;Monitor;Monoclonal Antibodies;Mus;neoantigens;new technology;novel;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Outcome;Pathway interactions;Patients;Population;Preparation;Process;programs;Proliferating;Proteins;Protocols documentation;Recovery;Research;Research Personnel;Resolution;Resource Sharing;response;Role;Sampling;scaffold;Scientist;Services;Signal Pathway;Site;Space Perception;Stains;Structure;synergism;System;targeted cancer therapy;targeted treatment;Technology;Testing;tissue biomarkers;tissue processing;Tissue Sample;tool;Training;Training Programs;translational research program;translational study;Treatment outcome;Treatment Protocols;treatment strategy;tumor;tumor immunology;Universities;Validation;Vendor;Visualization;Washington;Work

PROJECT_TITLE: Immunomonitoring Laboratory


PI_NAMEs: CHATENOUD, LUCIENNE  (contact)

PROJECT_TERMS: 5 year old;Affect;Age;Alleles;animation;Antigens;Attention;Autoantibodies;Autoimmune Diabetes;Autoimmune Diseases;Base Pairing;Beta Cell;Breeding;causal variant;Cells;Child;Clinic;Code;Complex;congenic;Congenic Mice;CRISPR/Cas technology;Cryopreservation;cytokine;Data;data dissemination;Databases;Date of birth;Detection;Developed Countries;Development;Diabetes Mellitus;Disease;DNA;Ear;Elements;Embryo;Environmental Risk Factor;Ethylnitrosourea;Etiology;Exhibits;experience;Female;forward genetics;Genes;Genetic;Genetic Drift;genetic pedigree;genetic technology;Genome;Genomic DNA;Genotype;germ free condition;Germ Lines;Harvest;Health;Hemorrhage;Heritability;high risk;Housing;Human;human disease;Human Resources;Hygiene;Hyperglycemia;Inbred NOD Mice;Inbreeding;Incidence;Induced Mutation;Infiltration;insulin secretion;Insulin-Dependent Diabetes Mellitus;Ions;Islets of Langerhans;Joints;Knock-out;Link;male;Maps;Mediating;Meiosis;Modification;Monitor;Mononuclear;mouse development;Mouse Strains;Mus;Mutagenesis;Mutagens;Mutation;Nitrosourea Compounds;novel;Pathogenesis;Periodicals;Phenotype;phenotypic data;Pre-Clinical Model;Predisposition;prevent;Prevention;programs;pup;Quantitative Trait Loci;receptor;Recovery;Research Personnel;reverse genetics;RNA Splicing;Role;screening;Siblings;sperm cell;sperm cryopreservation;Susceptibility Gene;T-Lymphocyte;Tail;Technology;Therapeutic;Time;Transgenic Organisms;Variant;web site

PROJECT_TITLE: Core C - Mutagenesis, Screening and Cryopreservation


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Artificial Intelligence;Big Data;biomedical informatics;Biostatistics Shared Resource;Cancer Center;Cancer Center Support Grant;Clinical;Clinical Research;Clinical Sciences;Collection;community center;Complex;Computer software;Consultations;Custom;Data;Data Analytics;Data Collection;Data Commons;Data Discovery;data integration;data management;Data Mart;data modeling;data resource;Data Set;data submission;data tools;data warehouse;deep learning;design;Development;electronic data;Electronic Health Record;electronic health record system;Faculty;Grant;Health care facility;Healthcare;Informatics;Information Management;Information Systems;Institution;instrument;Knowledge Management;Machine Learning;Malignant Neoplasms;medical schools;member;Mentored Clinical Scientist Development Program;Methodology;Methods;multiscale data;Natural Language Processing;Online Systems;operation;Patients;Performance;Persons;Phenotype;Physicians;Population;Preparation;programs;Public Health;Publications;Reporting;Research;Research Activity;Research Personnel;Resource Sharing;Resources;Services;Site;software development;Support System;synthetic data;Techniques;Technology;technology platform;Testing;Text;theories;Tissue Procurements;tool;Training;Translational Research;Triage;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Informatics Core Services


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Rare Diseases

PROJECT_TERMS: Acceleration;Acute Myelocytic Leukemia;Aftercare;Agreement;Algorithmic Analysis;analysis pipeline;Area;automated analysis;Basic Science;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological Assay;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer type;Cells;Clinical;clinical practice;Clinical Trials;cohort;Collaborations;Complex;Comprehensive Cancer Center;computer cluster;Computer software;computerized tools;Critiques;Data;data acquisition;Data Analyses;Data Discovery;density;design;Development;Enzymes;Equipment;experience;Experimental Designs;Faculty;Funding;Future;Generations;Genes;Genome;genome resource;Genomics;Goals;Guidelines;Human;improved;instrumentation;Label;Laboratories;large scale data;Leadership;Libraries;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;medical schools;member;Metabolic;Methods;migration;multiplex assay;National Cancer Institute;NCI Center for Cancer Research;new technology;next generation;North Carolina;Outcome;Peptide Sequence Determination;Peptides;Pharmaceutical Preparations;phosphoproteomics;Phosphorylation Site;Phosphotransferases;Post-Translational Protein Processing;programs;Protein Kinase;protein protein interaction;Proteins;proteogenomics;Proteome;Proteomics;Proteomics Shared Resource;Protocols documentation;Publications;recruit;repository;Reproducibility;Research;Resource Sharing;response;Sampling;Science;Services;Site;software development;Specificity;Specimen;Stable Isotope Labeling;Standardization;Technology;tool;Translational Research;tumor;United States National Institutes of Health;Universities;Validation;Washington;Work

PROJECT_TITLE: Proteomics Shared Resource


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adoptive Transfer;Affect;Agreement;Antigen Presentation;Attention;Autoantigens;Beta Cell;Bone Marrow Transplantation;Breeding;Cell Count;cell type;Cells;Cellular Immunology;Chromogranin A;Collaborations;conditional knockout;CRISPR/Cas technology;Data;Development;Diabetes Mellitus;diabetogenic;Disease;DNA Sequence Alteration;dominant genetic mutation;Ethylnitrosourea;Event;experimental study;FOXP3 gene;Gene Targeting;Genes;Genetic;Genome;Goals;Health;Hematopoietic stem cells;Human;Immune;Immune system;Immunologics;improved;in vivo;Inbred NOD Mice;Incidence;Induced Mutation;Infiltration;innovation;Insulin;Insulin Resistance;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;insulitis;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Knockout Mice;Laboratories;lymphoid organ;Maps;Measurement;Mediating;Metabolic;Missense Mutation;Molecular;molecular sequence database;Mus;Mutagens;Mutation;neonate;new therapeutic target;novel;Organoids;Orthologous Gene;Pathogenesis;Pathogenicity;Pathologic;Patients;Peptides;Phenotype;Phosphoric Monoester Hydrolases;Predisposition;prevent;Process;Proteins;Regulatory T-Lymphocyte;Research;success;synergism;T cell therapy;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic Intervention;Time;Tissues;tool;transcriptome;Transgenic Organisms;Work

PROJECT_TITLE: Project 1 - Immunologic and Cellular Mechanisms of T1D Modifier Mutations


PROJECT_TERMS: anti-cancer research;Basic Science;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Clinical Trials;Color;Competence;Complex;Computer software;Confusion;Contract Services;cost;craving;Cytometry;Data;Data Analyses;data management;Development;Discipline;Education;Ensure;Experimental Designs;experimental study;Failure;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;Genetic;Health Services Accessibility;Hour;Industry;Instruction;instrumentation;Lasers;Learning;Maintenance;Manufacturer;Marketing;member;Mission;new technology;Nomenclature;operation;Patient Schedules;Price;Process;Reagent;Recovery;repaired;Research Personnel;response;Science;Services;Sorting;Standardization;success;synergism;Target Populations;Techniques;Technology;Time;tool;Training;Training and Education;Vendor;Visualization;Work

PROJECT_TITLE: Siteman Flow Cytometry


PROJECT_TERMS: Address;Animal Cancer Model;animal imaging;Animal Model;Animals;anti-cancer research;Biological Models;bioluminescence imaging;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer health disparity;cancer imaging;Cancer Model;Clinic;Collaborations;Communities;Computer software;Consult;Consultations;Data Analyses;Data Set;Development;Diagnostic;Discipline;Discipline of Nuclear Medicine;disease model;Drug Kinetics;Education;Educational workshop;Ensure;experience;fluorescence imaging;frontier;Funding;Goals;Grant;Hamsters;Image;Image Analysis;image translation;imaging biomarker;Imaging Device;imaging facilities;imaging program;Imaging Techniques;Imaging technology;Infrastructure;Institution;instrument;interest;journal article;Laboratory Animal Models;Laboratory Animals;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Malignant Neoplasms;Manuscripts;member;metabolic abnormality assessment;Mission;Modality;Molecular;Molecular Biology;Mus;NCI Center for Cancer Research;optical imaging;Optical Tomography;Optics;Pathology;Peer Review;Population;Positron-Emission Tomography;pre-clinical;preclinical imaging;Preparation;Procedures;Productivity;programs;protocol development;Protocols documentation;quantitative imaging;Radio;Radiology Specialty;radiotracer;Rattus;Research;research and development;Research Design;Research Personnel;Research Support;Resource Sharing;Resources;Sampling;Scientist;single photon emission computed tomography;Small Animal Imaging Resource Programs;symposium;Technology;Textiles;Therapeutic;Therapeutic Agents;Therapeutic Clinical Trial;Time;tomography;Training;Transgenic Animals;Translating;translational potential;Translations;Treatment Efficacy;X-Ray Computed Tomography

PROJECT_TITLE: Small Animal Cancer Imaging


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Human Genome

PROJECT_TERMS: Accreditation;American;anti-cancer research;Archives;Basic Science;biobank;Biological Markers;biological specimen archives;Blood Cells;cancer biomarkers;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer genomics;cancer initiation;Cancer Patient;cell free DNA;Cells;Clinical;clinical translation;Clinical Trials;Clinical Trials Cooperative Group;Clinical Trials Network;clinically relevant;Collection;college;Computer software;Consensus;Consent;Consultations;cost effective;Cryopreservation;design;Dissociation;DNA;exosome;Fostering;Freezing;Future;Histologic;Histology;Human;human tissue;Immunologic Monitoring;improved;Informatics;informatics tool;Infrastructure;Institution;interest;Investigational Therapies;Journals;Laboratories;Lead;Leadership;Liquid substance;Malignant Neoplasms;member;Metagenomics;Methodology;Methods;Molecular Biology;National Cancer Institute;National Clinical Trials Network;next generation;Non-Malignant;novel;Nucleic Acids;Operative Surgical Procedures;Pathologist;Pathology;Patients;Peer Review;Plasma;Procedures;Process;programs;prospective;Proteomics;Publications;Publishing;quality assurance;Research;Research Personnel;research study;Resected;Resource Sharing;Resources;RNA;Role;sample collection;Sampling;Scientist;Serum;Services;single cell analysis;Solid;Solid Neoplasm;Specialized Program of Research Excellence;Specimen;Standardization;System;The Cancer Genome Atlas;Therapeutic Clinical Trial;tissue processing;Tissue Procurements;Tissues;Training;Translating;translational cancer research;Translational Research;translational study;tumor;Universities;Washington;Work

PROJECT_TITLE: Tissue Procurement Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: 3-Dimensional;ABCG2 gene;Acceleration;analysis pipeline;Animals;anti-cancer research;Area;Artificial Intelligence;Basic Science;Biological Assay;Biological Process;bone;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cell behavior;Cell Physiology;Cells;cellular imaging;Cellular Structures;Consultations;Consumption;Contrast Media;cost;Custom;data acquisition;Data Analyses;Data Set;Dedications;design;Detection;Development;Dimensions;Education;Educational workshop;Electron Microscopy;Electrons;Ensure;Equipment;Experimental Designs;Face;Fluorescence;fluorescence microscope;Funding;Future;Gastric Tissue;Generations;Goals;Human Resources;Image;Image Analysis;Imaging Techniques;Imaging technology;improved;Individual;Informatics;innovation;Institution;instrumentation;intravital microscopy;Investments;Ions;Journals;Laboratories;Laboratory Research;Learning;lectures;Light;light microscopy;long bone;loss of function;Malignant Neoplasms;member;Methodology;Microscope;Microscopic;microscopic imaging;Microscopy;molecular imaging;Morphology;mouse model;Mus;nanoscale;Neoplasm Metastasis;neoplastic cell;novel;operation;Optics;Organism;Organoids;Physiological;Preparation;programs;Property;quantitative imaging;Research;Research Personnel;research study;Resolution;Resource Sharing;Roentgen Rays;Sampling;Scanning Electron Microscopy;Services;single molecule;Specialist;Specimen;Speed;Structure;superresolution imaging;superresolution microscopy;System;Technical Expertise;Techniques;Technology;technology platform;Time;Tissue imaging;Tissue Microarray;Tissues;tool;Training;Translational Research;translational study;treatment strategy;tumor progression;two-dimensional;two-photon;United States National Institutes of Health;Universities;Visualization;Washington;Work;X ray microscopy

PROJECT_TITLE: Washington University Center for Cellular Imaging


PROJECT_TERMS: Acceleration;Actins;Affect;Alleles;Animals;Apoproteins;Apoptotic;Attention;autoreactivity;B-Lymphocytes;Beta Cell;Binding;Biological Assay;Candidate Disease Gene;cell motility;Cell Physiology;Cell Separation;Cell Survival;cell type;Cells;Communication;Communities;Complex;conditional knockout;CRISPR/Cas technology;Crystallization;CTLA4 gene;Data;Development;Diabetes Mellitus;Disease;Disease remission;DNase-I Footprinting;Educational process of instructing;Engineering;epigenetic regulation;Epitopes;Ethylnitrosourea;Etiology;Exclusion;Funding;Genes;Genetic;genetic pedigree;Germ Lines;Human;Immune;In Vitro;Induced Mutation;Insulin-Dependent Diabetes Mellitus;interest;Investigation;Islets of Langerhans;Knock-out;knockout gene;Knowledge;Lead;Location;Maps;Mass Spectrum Analysis;Measures;Meiosis;Methodology;Methods;Microfilaments;Missense Mutation;Molecular;Molecular Sieve Chromatography;Mus;Mutagens;mutant;Mutant Strains Mice;Mutation;N-terminal;novel;Pathogenesis;Patients;Peptides;Phase;Phenotype;phosphoproteomics;Post-Translational Protein Processing;Prevention;Protein Analysis;protein complex;protein function;Protein Isoforms;Protein Overexpression;protein protein interaction;protein purification;Proteins;Proteomics;Recovery;Recreation;response;Signal Pathway;Signal Transduction;Splice-Site Mutation;Suppressor Mutations;synergism;T cell receptor repertoire sequencing;T cell response;T-Cell Depletion;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;Time;Tissues;transcriptomics;Tumor Necrosis Factor Receptor;Untranslated RNA;Work

PROJECT_TITLE: Project 2 - Verification and Molecular Mechanisms of T1D Modifier Mutations


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Addressing the complex challenges facing the nation’s health care system requires diverse perspectives and disciplines. This post-doctoral training program is designed for both clinicians seeking to become clinician-researchers by acquiring health services research skills, as well as PhD-trained economists seeking to apply their methodological expertise to the field of health services research. We aim to train future leaders in health services research who will address our health care delivery system’s most pressing problems and make health care organization and delivery higher quality, safer, more efficient, and equitable.

PI_NAMEs: GROENEVELD, PETER W. (contact);WERNER, RACHEL M

PROGRAM_OFFICER_NAME: CHANLONGBUTRA, AMORNRAT

PROJECT_TITLE: Postdoctoral Training in Health Services Research


NIH_SPENDING_CATS: Cancer;Immunotherapy

PROJECT_TERMS: ABCG2 gene;anti-tumor immune response;Basic Science;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;cancer initiation;Cancer Patient;Cells;clinical translation;Clinical Trials;clinically relevant;Collaborations;collaborative environment;Communities;Comprehensive Cancer Center;Disease;Effectiveness;Environment;Experimental Models;Funding;Future;Goals;Immune;Immune system;Immunologics;Immunology;Immunotherapy;immunotherapy clinical trials;Infrastructure;Intervention;Intervention Trial;Laboratories;Malignant Neoplasms;Manuscripts;medical schools;member;Mission;Modeling;Nature;NCI Center for Cancer Research;novel;novel therapeutics;Peer Review;Physicians;programs;Publishing;Research;Research Personnel;Resource Sharing;Resources;Role;Scientist;Testing;Translating;Translational Research;Translations;tumor;tumor immunology;tumor microenvironment;Universities;Washington

PROJECT_TITLE: 03 Tumor Immunology Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Acute Myelocytic Leukemia;Acute T Cell Leukemia;African American;Area;Award;Basic Science;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer genome;cancer genomics;Cellular biology;Cellular immunotherapy;chemotherapy;Clinical;Clinical Trials;Clonal Evolution;Collaborations;community engagement;Community Outreach;CXCR4 gene;Data;Development;Direct Costs;Disease;Dysmyelopoietic Syndromes;Epigenetic Process;experience;Fellowship;Female;Fostering;Foundations;fundamental research;Funding;Genes;Genetic;Genomics;Goals;Grant;Grant Review;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Heterogeneity;Hispanic;Immunology;Immunotherapy;improved;indexing;inhibitor therapy;innovation;Institution;International;Intervention;Intervention Trial;Investments;Journals;K-Series Research Career Programs;Latino;Leadership;leukemia;leukemia/lymphoma;Leukemic Cell;Lymphoma;Malignant - descriptor;Malignant Neoplasms;medical schools;medically underserved population;meetings;member;Minority;Minority Participation;Multiple Myeloma;Mutate;Myelodysplastic/Myeloproliferative Disease;Myeloproliferative disease;nanotherapy;Newly Diagnosed;next generation sequencing;NF-kappa B;novel;novel strategies;novel therapeutics;Paper;Pathway interactions;Patients;Peer Review;prevent;Program Research Project Grants;Program Reviews;programs;Publishing;Recurrence;Reporting;Research;research and development;Research Personnel;Role;senior faculty;Signal Transduction;Societies;Stem cell transplant;success;Support Groups;Therapeutic Intervention;therapy resistant;Training;Translating;translational goal;translational potential;Translational Research;treatment response;treatment strategy;tumor immunology;United States National Institutes of Health;Universities;Washington;working group

PROJECT_TITLE: 04 Hematopoietic Development and Malignancy Program


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PROJECT_TERMS: Acceleration;Achievement;Address;Administrator;anti-cancer research;Area;Basic Science;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;career;Catchment Area;Cells;Chemoprevention;Cigarette;cigarette smoking;Cities;Clinical;Clinical Medicine;clinical practice;Clinical Research;Collaborations;Colon Carcinoma;Communities;community intervention;community setting;Comprehensive Cancer Center;County;Data Analytics;Detection;Diagnosis;Discipline;Disparity;Dissemination and Implementation;dissemination science;Early Diagnosis;Economics;Enrollment;Environment;Epidemiology;Equity;ethnic minority;Ethnic Origin;Evidence based intervention;Evidence based practice;Exhibits;Family;Federally Qualified Health Center;Funding;Genetic study;Geography;Goals;Health;Health Benefit;Health Disparities Research;Health system;Illinois;implementation design;implementation research;implementation science;improved;Incidence;Individual;innovation;Intervention;Intervention Studies;Lead;Leadership;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medicaid;member;Methods;Missouri;mortality;Nicotine Dependence;Outcome;Participant;patient oriented;Peer Review;Policies;Policy Maker;Policy Research;Population;population health;prevent;Prevention;Preventive service;programs;Provider;Psychology;Public Health;Public Health Practice;Publishing;Race;racial minority;Religion;Research;Research Activity;Research Personnel;Research Priority;Resource Sharing;Rest;Risk;Risk Factors;Rural;Rural Health;Schools;Scientist;Screening for cancer;smoking cessation;Societies;socioeconomic diversity;Statistical Data Interpretation;survivorship;Taxes;Tobacco use;Tobacco-Related Carcinoma;Training;translational impact;Translational Research;Translations;Universities;Washington

PROJECT_TITLE: 06 Prevention and Control Program


ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE This research addresses a central challenge in current global health research, the burden of stunting among infants in low- and middle-income countries facing a high burden of enteric infection. With this award, I will build an independent, interdisciplinary research program that bridges community-based enteric disease research and advanced computational modeling methods for systems epidemiology. This research will inform interventions to reduce the burden of infectious diseases on infants and children living in low- and middle-income countries.

PI_NAMEs: LEE, GWENYTH O'NEILL (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Address;Adult;Affect;Age;Age Months;antagonist;Area;Award;Behavior;Biological;Biological Models;Birth;bridge program;Calibration;Campylobacter;career;Child;Childhood;Chronic;cognitive development;cohort;Communicable Diseases;Communities;community based research;Complex;Computer Models;Data;Data Set;deprivation;design;Development;Diet;dietary;Dietary Factors;Disease;dynamic system;early childhood;Ecuadorian;Elements;energy balance;Ensure;Enteral;enteric infection;enteric pathogen;Epidemiology;epidemiology study;experience;Exposure to;Fatty acid glycerol esters;Feedback;feeding;Funding;Giardia;girls;global health;Goals;Growth;Height;Human;Immunity;improved;In Situ;Income;indexing;Individual;infancy;Infant;Infant Development;Infant Health;Infection;infection risk;innovation;Intake;Interdisciplinary Study;interest;Intervention;Knowledge;Leadership;Life;low and middle-income countries;Malnutrition;maternal outcome;mathematical model;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolism;Methodology;Methods;Michigan;Modeling;National Institute of Allergy and Infectious Disease;Nutrient;Nutritional;nutritional epidemiology;Nutritional status;Outcome;Output;pathogen;Pattern;Positioning Attribute;Poverty;prevent;Process;programs;Proteins;Regulation;Reporting;Research;Research Personnel;Resources;Rotavirus;Rural;Sampling;Social Conditions;System;Testing;Time;tool;Training;training project;Universities;Update;Vitamin A;Work;Zinc

PROJECT_TITLE: Dynamic modeling of antagonism between enteric infection and undernutritionin infancy

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

PROJECT_TERMS: Academia;Acceleration;Address;Animal Model;Animals;Area;Artificial Intelligence;Automobile Driving;Award;Basic Cancer Research;Basic Science;Behavior;Binding;Biological;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer imaging;cancer therapy;Chemotherapy and/or radiation;Clinic;Clinical;clinical decision-making;clinical translation;Collaborations;Creativeness;Data;data mining;deep learning;Detection;detector;Development;Diagnosis;Diagnostic Procedure;Educational workshop;Engineering;Environment;Event;Extramural Activities;Faculty;Financial Support;fluorescence molecular tomography;Fostering;Funding;Funding Opportunities;Goals;Grant;Human;Hybrids;Image;image guided;Image-Guided Surgery;imaging agent;imaging biomarker;Imaging Device;imaging facilities;imaging informatics;imaging modality;imaging probe;imaging program;imaging system;Imaging technology;improved;in vivo Cellular and Molecular Imaging Centers;Industry;industry partner;Informatics;Information Retrieval;innovation;insight;Institution;instrument;instrumentation;Investments;Knowledge;Lasers;Leadership;lectures;machine learning algorithm;Magnetic Resonance Imaging;Malignant Neoplasms;member;Mentors;Methodology;Methods;microPET;Molecular;molecular imaging;Monitor;multidisciplinary;Multimodal Imaging;Multiple Myeloma;nanotherapy;Nature;next generation;NMR Spectroscopy;novel;Optics;optoacoustic tomography;patient response;Patient-Focused Outcomes;Patients;Peer Review;PET/CT scan;Phenotype;photoacoustic imaging;physical science;Pilot Projects;Positron-Emission Tomography;pre-clinical;Prediction of Response to Therapy;Process;Productivity;programs;Property;proton beam;Publications;quantitative imaging;radiation response;Radioisotopes;radiomics;Recording of previous events;Research;Research Activity;Research Infrastructure;Research Personnel;Resolution;Resource Sharing;Resources;response;Scholarship;Schools;Science;Signal Transduction;skills;student mentoring;student training;Students;System;targeted treatment;Testing;theranostics;Therapeutic;tool;Training;Translating;translational pipeline;Translational Research;Translations;Treatment outcome;Treatment Protocols;treatment response;tumor;tumor progression;ultrasound;United States National Institutes of Health;Vision

PROJECT_TITLE: 08 Oncologic Imaging Program


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

PROJECT_TERMS: Achievement;Area;Basic Science;Benign;Biological Assay;Body Weight decreased;breast cancer progression;Breast Cancer Risk Factor;Breast Cancer survivor;Breast Cancer therapy;Breast Cancer Treatment;Cancer Center Support Grant;cancer clinical trial;cancer genomics;Cancer Research Project;Cells;Child;Childhood;CLIA certified;Clinical;clinical application;clinical investigation;Clinical Oncology;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials;clinically relevant;Cohort Studies;Collaborations;Communication;design;Development;Diagnosis;Diet;Disease;Disparity;disparity reduction;DNA Vaccines;drug-sensitive;Etiology;Funding;Future;Genetic;Genome;Genomic approach;genomic predictors;Genomics;Genotype;Goals;Growth;Height;Human;Human Subject Research;Image;Immunobiology;immunogenic;implementation strategy;improved;Incidence;Individual;Institution;International;Investments;Journal of the National Cancer Institute;Journals;Leadership;Lesion;Life Style;Malignant Breast Neoplasm;Malignant Neoplasms;member;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;Nature;Neoplasm Metastasis;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Paper;Pathology;patient derived xenograft model;Patient-Focused Outcomes;Patients;Peer Review;personalized strategies;personalized therapeutic;Population Sciences;Positioning Attribute;pre-clinical;predictive marker;Predisposition;premalignant;Prevention program;Prevention strategy;Productivity;programs;prospective;Proteomics;Publications;Publishing;Reporting;Research;Research Personnel;Risk;Risk Factors;risk variant;Role;Schools;Signal Transduction Pathway;Somatic Mutation;successful intervention;Therapeutic;therapeutic target;Tissue Banks;Translating;Translational Research;tumor microenvironment;Universities;vaccine development;Validation;Washington;Woman;working group

PROJECT_TITLE: 09 Breast Cancer Research Program