ORG_CITY: ALBUQUERQUE

ORG_NAME: ALBUQUERQUE VA MEDICAL CENTER

ORG_STATE: NM

PHR: Project Narrative Tuberous sclerosis complex (TSC) is a genetic disease caused by mutations in either the TSC1 (Hamartin) or TSC2 (Tuberin) gene and affects over two million people world-wide. Over 80% of patients with TSC develop renal disease, in the form of tumors and cysts, which can eventually lead to kidney failure. The factors that promote cyst generation and progression remain unknown. In this application, we report a novel mechanism for cyst formation and expansion which indicates that TSC cysts are driven by the creation of an imbalance in the population of cells lining the cyst. In this model, genotypically normal intercalated cells become the dominant cell type and the targeted principal cells gradually disappear. These results are new paradigms that will greatly advance our understanding of the pathophysiology of TSC renal disease and can be leveraged in the development of new therapeutic approaches for the treatment of this devastating disease.

PI_NAMEs: SOLEIMANI, MANOOCHER  (contact)

PROJECT_TERMS: Acetazolamide;Acids;Affect;Animal Experiments;Animal Model;antagonist;Antibodies;Antigens;Apical;apical membrane;autosome;base;Biological Factors;Biological Process;Blood Pressure;Carbonic Anhydrase II;Carbonic Anhydrase Inhibitors;Cell Line;Cell Proliferation;cell type;Cells;Chlorides;CLC Gene;Cyst;Cystic Fibrosis Transmembrane Conductance Regulator;Cystic kidney;Cystic Kidney Diseases;Cytoplasm;Data;Development;Disease;Dominant Genetic Conditions;Electrolytes;Epithelial cyst;Event;Fluids and Secretions;FRAP1 gene;Functional disorder;Gene Deletion;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Diseases;Genotype;Growth;Histology;Human;Image;Immunofluorescence Microscopy;inhibitor;Intercalated Cell;Kidney;Kidney Diseases;Kidney Failure;Knockout Mice;Label;late endosome;Lead;Life Expectancy;Lung;Lysosomes;Magnetic Resonance Imaging;Membrane;Modeling;Mus;Mutant Strains Mice;Mutation;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Organ;Outcome;Pathway interactions;Patients;Peptides;Pericytes;Persons;pharmacologic;Play;Population;Proliferating;Property;prorenin receptor;Proton-Translocating ATPases;Publishing;Regulation;Renal function;Reporting;Resistance;Role;SDZ RAD;Systemic blood pressure;Testing;transcription factor;transcriptome sequencing;TSC1 gene;TSC2 gene;Tuberous Sclerosis;tumor;V2 Receptors;WNT Signaling Pathway

PROJECT_TITLE: The Role of Intercalated Cells and Their Acid Base and Electrolyte Transport Machinery in Kidney Cystogenesis by Tuberous Sclerosis


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Project Narrative  Chronic kidney disease (CKD) affects 26–30 million U.S. adults including Veterans. Renal fibrosis is the inevitable consequence of almost every type of CKD regardless of underlying etiology. Unilateral ureteral obstruction (UUO) is a common and well-validated renal fibrosis experimental model. Big potassium (BK) channel is one of the two major potassium (K) channels responsible for renal K excretion. We have compelling preliminary evidence that shows for the first time that BKα plays a critical role in renal fibrosis. While BKα knockout mice were prone to developing more severe fibrosis after UUO, pre-treatment with the BK channel activator protected mice from developing renal fibrosis in wild-type UUO mice. Elucidation of the molecular mechanisms underlying the BK-mediated development of renal fibrosis will provide novel insights into whether BK channels can be utilized as a potential therapeutic target for treating CKD patients.

PI_NAMEs: CAI, HUI  (contact)

PROJECT_TERMS: Adult;Affect;Biopsy Specimen;Blood Vessels;Cell Aging;Cell Cycle Arrest;Cell Line;Cell Separation;Cells;Chronic Kidney Failure;Clinical;Clinical Trials;cytokine;Data;Development;Diabetic Nephropathy;disease model;End stage renal failure;Etiology;Excretory function;Experimental Models;Fatty acid glycerol esters;Fibroblasts;Fibrosis;Focal and Segmental Glomerulosclerosis;Folic Acid;Human;insight;interstitial;Kidney;kidney biopsy;Kidney Diseases;kidney fibrosis;Knock-out;Knockout Mice;large-conductance calcium-activated potassium channels;Literature;Mediating;Membrane Microdomains;Modeling;Molecular;mouse model;Mus;novel;Obese Mice;Pathogenesis;Pathway interactions;Patients;Phase;Play;Potassium;Potassium Channel;prevent;Profibrotic signal;Protein Isoforms;Public Health;Rattus;renal epithelium;Reporting;Role;Severities;Signal Pathway;Testing;therapeutic target;Time;Transforming Growth Factor beta;Translating;Tubular formation;Ureteral obstruction;Veterans;Wild Type Mouse

PROJECT_TITLE: Role of BK Channel in Chronic Kidney Disease


ORG_CITY: SAN FRANCISCO

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

ORG_STATE: CA

PHR: Neurodegenerative diseases represent a major challenge in the health care for the civilian and Veterans populations. In particular, there are concerns that exposure to chemicals or injury during combat may increase the propensity of neurodegeneration in Veterans. ALS is a fatal neurodegenerative disease characterized by rapidly progressive loss of motor neurons in brain and spinal cord. By analyzing ALS mouse models and a large number of tissue samples from FALS and SALS patients, we show that misfolded proteins activate a highly conserved protein kinase, called HIPK2, which serves as a molecular switch to promote neuronal cell death, leading to hypothesize that HIPK2 is a feasible therapeutic target for ALS. To test this, we will (1) characterize HIPK2 interacting partner HSPA9 (Mortalin) and their roles in regulating neuronal survival in preclinical models of ALS, and (2) characterize the broader role of HIPK2 in astroglial pathology in ALS.

PI_NAMEs: HUANG, ERIC J (contact)

PROJECT_TERMS: Adult;Affect;Aggressive Clinical Course;ALS patients;Amyotrophic Lateral Sclerosis;Astrocytes;Axonal Transport;Biochemical;Bioenergetics;Biological Assay;blood-brain barrier crossing;Brain;burden of illness;C9ALS;C9ORF72;Cell Death;Cell Death Induction;Cell model;Cell Physiology;Cells;Chemicals;combat;Development;Disease;Disease Progression;endoplasmic reticulum stress;Equilibrium;Exposure to;familial amyotrophic lateral sclerosis;Freezing;Funding;Gene Expression;Gene Expression Regulation;General Population;Genes;glucose-regulated proteins;Goals;GRP75;Healthcare;Heat shock proteins;homeodomain;Injury;insight;kinase inhibitor;Mediating;member;Microglia;military veteran;misfolded protein;Mitochondria;Modeling;Molecular;Morphology;mortalin;Motor Neurons;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Mutation;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;neuronal survival;Neurons;Parkin;Pathogenesis;Pathology;Pathway interactions;Patients;Phosphotransferases;Pre-Clinical Model;Protein Family;Protein Kinase;Protein Kinase Interaction;protein misfolding;protein TDP-43;Proteins;Proteomics;proteostasis;RNA metabolism;Role;Signal Pathway;single-cell RNA sequencing;Spinal;Spinal Cord;sporadic amyotrophic lateral sclerosis;statistics;Stress;superoxide dismutase 1;Synapses;Testing;therapeutic target;Tissue Sample;Tissues;Toxic effect;Toxin;trafficking;Transcriptional Regulation;transcriptomics;Ubiquitin;unpublished works;Veterans

PROJECT_TITLE: Mechanisms of ER Stress and Neurodegeneration in Amyotrophic Lateral Sclerosis


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Normal brain function depends on the orderly development of circuits in the cerebral cortex and on their intact function. Knowledge of the normal circuitry provides a foundation for understanding the causes of impaired brain function and developing corrective measures. Our studies of the normal circuitry involving inhibitory neurons in early visual cortical areas will provide greater insight into the causes and effects of central vision defects when these circuits are damaged by stroke or other neurological or developmental cause. Moreover, our studies of inhibitory neuron function will provide a foundation for understanding the consequences of their dysfunction in neurological and psychiatric disorders, such as seizure disorders (Zhang et al., 2009; Halabisky et al., 2010; Peng et al., 2013) and schizophrenia (Hashimoto et al., 2003; Volk et al., 2012), which have been associated with alterations in gene expression, abnormal function or anatomy of distinct types of inhibitory neurons, including PV and SOM neurons.

PI_NAMEs: ANGELUCCI, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Anatomy;Animal Model;Anxiety;Area;area striata;autism spectrum disorder;Autopsy;Axon;Behavioral;Biological Models;Brain;brain dysfunction;Calcium;calcium indicator;Callithrix;Cell Nucleus;cell type;Cells;Cerebral cortex;Chemicals;Computer Models;Contrast Sensitivity;D Cells;Data;Defect;Dendrites;Development;Disease;Electrodes;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Epilepsy;Equilibrium;Explosion;Feedback;Foundations;Functional disorder;Gene Expression;genetic manipulation;Geometry;Glutamates;Goals;Human;Image;Immunohistochemistry;in vivo;inhibitory neuron;insight;Knowledge;Lateral;Literature;Location;Maps;Measures;Mediating;Mental disorders;molecular marker;Morphology;Mus;Myoepithelial cell;Neocortex;Nervous System Disorder;neural circuit;Neurologic;neuronal cell body;Neuronal Dysfunction;Neurons;Opsin;optogenetics;Parvalbumins;Pattern;Physiological;Population;Primates;Property;Publishing;rabies viral tracing;Rabies virus;receptive field;Recurrence;response;Rodent;Role;Schizophrenia;selective expression;Sensory;sensory cortex;Somatostatin;Source;Stimulus;Stress;Stroke;Technology;Testing;tool;Transgenes;transmission process;two-photon;V1 neuron;Vasoactive Intestinal Peptide;Viral;Vision;Visual;Visual Cortex;visual processing;visual stimulus;Work

PROJECT_TITLE: Connectivity and function of inhibitory neurons in the primate visual cortex


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: The goal of the proposed research is to identify the circuit-level mechanisms in the auditory cortex and anterior cingulate cortex that underlie auditory prediction and to test the way these mechanisms contribute to behavioral detection of regularity in sounds and its violation. This is achieved by using a combination of electrophysiological, optogenetic and behavioral approaches in the mouse system. Patients with hearing deficits, age-related hearing loss and communication deficits, exhibit disproportionate difficulty hearing when several sound sources are present. Identifying the function of specific neuronal circuits in the auditory pathway and their relation to predictive coding, which has been implicated in auditory source segregation, is a prerequisite for development of new and improvement of existing therapies for these large groups of patients.

PI_NAMEs: GEFFEN, MARIA NEIMARK (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Circuit Mechanisms of Sound Processing and Detection in the Auditory Pathway


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Although supervised exercise is first line therapy for people disabled by lower extremity peripheral artery disease (PAD), 45% of people with PAD do not meaningfully improve after exercise. This clinical trial of supervised exercise in PAD will test the hypothesis that changes in plasma nitrite levels during exercise activity mediate response to exercise and that people who do not respond to exercise fail to increase plasma nitrite levels during walking exercise activity. Results will be used to identify therapeutic targets for future interventions, to improve walking performance in people disabled by PAD.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: 4 hydroxynonenal;Biological;Biological Availability;Biopsy;Blood capillaries;brachial artery;Cardiovascular Diseases;Cardiovascular system;Clinical Trials;comparison control;consumption measures;Control Groups;Cyclic GMP;Data;density;Disabled Persons;Disease;Exercise;exercise intervention;Exercise Test;follow-up;Future;Gait abnormality;Gastrocnemius Muscle;Half-Life;improved;Intervention;Juice;Leg;Lower Extremity;Measures;Mediating;Mediator;Medical;Mitochondria;Muscle;Muscle Mitochondria;Muscle satellite cell;Nitrates;Nitric Oxide;Nitric Oxide Synthase;Nitrites;Outcome;Oxidative Stress;Participant;Pathway interactions;Patients;Perfusion;Peripheral arterial disease;Persons;Placebos;Plasma;Production;Randomized;randomized trial;Reporting;Research Personnel;response;shear stress;Skeletal Muscle;Spirometry;Testing;tetrahydrobiopterin;therapeutic target;Time;treadmill;Walking;walking performance

PROJECT_TITLE: Response to Exercise and Nitric Oxide in PAD: the RESIST PAD Trial

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Lymphatic Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Our studies will uncover a novel target for inhibiting pathological lymphatic vessel formation, which may benefit cancer treatment and organ transplantation. Thus, the proposed research is relevant to public health and supports the NIH mission of seeking fundamental knowledge that will help lengthen life and reduce illness.

PI_NAMEs: YU, PENGCHUN  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Ablation;absorption;Address;advanced analytics;allograft rejection;analytical tool;Blood Vessels;cancer therapy;cancer transplantation;Cell model;cell motility;Cell Proliferation;cell type;Chemicals;Complex;Cornea;Couples;Data;Development;Dietary Fats;Disease;Drainage procedure;Environment;Equilibrium;Exhibits;FRAP1 gene;Generations;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Glucose;Glucose-6-Phosphate;Glycolysis;Goals;Health;Hexokinase 2;Impairment;implantation;innovation;Knowledge;lactate dehydrogenase A;Life;Link;Liquid substance;Lymphangiogenesis;Lymphatic;lymphatic development;lymphatic dysfunction;Lymphatic Endothelial Cells;lymphatic vasculature;lymphatic vessel;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mission;Modeling;Molecular;mouse model;Mus;MYC gene;NADH;Natural regeneration;Neoplasm Metastasis;Neoplasm Transplantation;Nicotinamide adenine dinucleotide;novel;Nucleotide Biosynthesis;nucleotide metabolism;Organ;Organ Transplantation;Oxidation-Reduction;Oxygen;Pathologic;Pentosephosphate Pathway;Pentoses;pharmacologic;Physiological;Physiological Processes;Play;Process;Production;programs;Proliferating;Proto-Oncogene Proteins c-myc;Public Health;Pyruvate;Radioisotopes;Research;reverse cholesterol transport;Role;Signal Induction;Signal Transduction;Testing;Tissues;tumor;United States National Institutes of Health;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factors;Warburg Effect;Work

PROJECT_TITLE: Metabolic mechanisms controlling lymphatic vessel formation

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: LEMBA

ORG_COUNTRY: CONGO DEM REP

ORG_FIPS: CG

ORG_NAME: CENTRE DE GENETIQUE HUMAINE

PHR: PROJECT NARRATIVE About 1 in 20 individuals in the world could be affected by a rare disease. A good care starts with a good diagnostics. Unfortunately, people from Low and Middle-Income Countries (LMICs) do not have access to good diagnostics. The situation of rare diseases in those countries is globally unknown. Genomic medicine consists in using genomic information to make health decisions. The fact that little is known from some parts of the world prevents those parts of the world from having access to good genomic medicine. By helping rare diseases patients in the Democratic Republic of Congo (DRC), we will also help patients in other regions of the world as well. The DRC is a genomically rich country, where experienced clinical geneticists trained oversee are now available and mobile internet has become available. We are a group of Congolese researchers who have come together to build a network that will generate good quality information and will improve the diagnosis in Congolese rare diseases patients, while also helping non-African patients across the world. We will also develop a model and tools applicable to other LMICs willing to embrace genomic medicine.

PI_NAMEs: LUMAKA ZOLA, AIME  (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Advocacy;Affect;Africa;Africa South of the Sahara;African;Atlases;Awareness;Bioinformatics;bioinformatics tool;Biological;Caring;Clinical;clinical training;ClinVar;Collaborations;college;Communities;community engagement;Community Medicine;computer infrastructure;computerized data processing;computing resources;Consultations;Counseling;Country;Data;Data Analyses;Data Collection;data mining;data sharing;Databases;Democratic Republic of the Congo;design;Development;Diagnosis;Diagnostic;Disease;electronic registry;Epidemiology;Ethics;Evaluation;experience;Family;Feedback;Frequencies;Genetic;Genetic Counseling;genome analysis;genomic data;Genomic medicine;Genomics;Government;Health;health record;Human;Human Genetics;improved;Individual;Infrastructure;innovation;Institution;International;Internet;Knowledge;Link;low and middle-income countries;malformation;Medical Records;Medicine;meetings;mobile application;Modeling;Nomenclature;Paper;Patients;pediatrician;Pediatrics;Persons;Phenotype;Physicians;Policies;Population;Population Heterogeneity;prevent;Prevention;Procedures;Production;Protocols documentation;Public Domains;Publications;quality assurance;Rare Diseases;rare genetic disorder;Registries;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;Running;sample collection;Sampling;Scientist;screening;skills;Societies;Source;Students;Syndrome;Technology;tool;Training;Translating;Translations;Transportation;trend;United States National Institutes of Health;Universities;Variant;Visit

PROJECT_TITLE: African Rare Diseases Initiative (ARDI): Advancing Genomic Medicine through rare diseases research in Africa


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Diabetes;Emerging Infectious Diseases;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Beta cell dysfunction and death are significant pathologies underlying the development of Type 2 diabetes. The goal of this application is to understand the acute and long-term effects of SARS-CoV2 infection on beta cell survival, metabolism, and function. These experiments will provide critical molecular mechanistic insight into the reported post-acute sequelae of hyperglycemia, diabetic ketoacidosis, and potentially lifelong diabetes that may afflict a significant number of patients who have recovered from COVID19.

PI_NAMEs: GEORGIA, SENTA K (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: 2019-nCoV;Accident and Emergency department;Acute;acute infection;Address;Adult;Affect;Animal Model;Animals;Atrophic;Autopsy;Beta Cell;Biological Assay;Biological Models;blood glucose regulation;Cadaver;capsule;cell free DNA;cell injury;Cell Physiology;Cell Respiration;Cell Survival;Cellular Metabolic Process;Cessation of life;Clinical;clinical phenotype;clinically relevant;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 patient;COVID-19 survivors;Data;design;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic Ketoacidosis;Disease;DNA;DNA Methylation;experimental study;Face;Functional disorder;Future;Glucose;Goals;Health;Human;Hyperglycemia;improved;In Vitro;in vivo;in vivo Model;Infection;Injury;innovation;insight;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans Transplantation;Kidney;Literature;Long COVID;long term consequences of COVID-19;long term recovery;Long-Term Effects;Macaca mulatta;Measures;Mediating;Metabolic;Metabolism;methylation pattern;Mitochondria;Modeling;Molecular;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;observational cohort study;Odds Ratio;Outcome;Pancreas;Paper;Pathogenesis;Pathology;Patients;Physiological;Plasma;Post-Acute Sequelae of SARS-CoV-2 Infection;post-transplant;Predisposition;Prevalence;prevent;Primates;programs;Registries;Reporting;Reproducibility;Resolution;Respiratory System;Sampling;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Secondary to;Serum;severe COVID-19;small molecule;Stress;Structure of beta Cell of islet;Study models;Symptoms;Techniques;Testing;Therapeutic Intervention;Transplantation;Viral Pathogenesis

PROJECT_TITLE: Beta cell dysfunction as an acute and a post acute sequelae of COVID19

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Project Narrative Diseases of the dopamine system such as substance use disorder, schizophrenia, Parkinson's disease, and other movement disorders including chorea and dystonia, have a tremendous personal and societal cost. The causes of the diseases are often unknown, but dopamine D2 receptors have been implicated in the pathophysiology or treatment of each of them. This work is expected to identify novel mechanisms by which dopamine D2 receptor mutations cause extrapyramidal motor system dysfunction.

PI_NAMEs: NEVE, KIM ARTHUR (contact)

PROJECT_TERMS: Adolescence;Affect;Agonist;Arrestins;autosome;Benign;Binding;Biological;Brain;Cells;Cervical Dystonia;Characteristics;Chorea;Clinical;clinical phenotype;Cognitive deficits;Cyclic AMP;Cytoplasm;Data;de novo mutation;Dependence;Disease;Dopamine D2 Receptor;Dopamine Receptor;dopamine system;dopaminergic neuron;DRD2 gene;Dystonia;early onset;Electrophysiology (science);Exhibits;Exons;Face;Family;Functional disorder;G-Protein-Coupled Receptors;Gait abnormality;Generations;Genetic Polymorphism;genetic variant;Goals;GTP-Binding Proteins;Heterozygote;Human;Impairment;in silico;in vivo;inward rectifier potassium channel;Kinetics;Knock-in Mouse;Lead;Learning;Link;Location;Mediating;member;Mental disorders;Midbrain structure;Modeling;molecular dynamics;Motor;motor impairment;mouse model;Movement;Movement Disorders;Mus;mutant;Mutation;Neostriatum;Nervous System Disorder;Neurologic Dysfunctions;Neurologic Symptoms;neuroprotection;neuropsychiatric symptom;neuropsychiatry;novel;Outcome;Parkinson Disease;Pathogenicity;Phosphorylation;Phosphotransferases;Positioning Attribute;Potassium Channel;Property;protein activation;receptor;Receptor Activation;receptor expression;receptor function;recruit;Regulation;RNA Splicing;Role;Schizophrenia;Severities;Signal Transduction;Single Nucleotide Polymorphism;Slice;societal costs;Spasm;Substance Use Disorder;System;therapeutic target;Transmembrane Domain;Variant;Viral;Work

PROJECT_TITLE: Dopamine D2 Receptor Mutations and Hyperkinetic Movement Disorders


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: FLAGSTAFF

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: Microbiome research is expanding horizons across the cancer research continuum, and we are currently developing an understanding of how our microbiota may impact carcinogenesis, how microbiota may impact the efficacy of cancer treatment, how cancer treatment may impact the microbiota, and associations between the microbiome and cancer prognosis. Our team proposes to advance cancer microbiome research by improving access to cancer microbiome bioinformatics methods and data, developing a microbiome multi- omics bioinformatics platform driven by the needs of the cancer research community, and ensuring reproducibility of microbiome bioinformatics methods. This will be achieved in the context of the popular QIIME 2 microbiome bioinformatics platform and the Qiita public microbiome data repository and pooled analysis system, in collaboration with ITCR and NCI Cloud Resources project teams.

PI_NAMEs: CAPORASO, JAMES GREGORY (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Advanced Development;Advanced Malignant Neoplasm;anti-cancer research;Architecture;Area;Bioinformatics;bioinformatics tool;Cancer Detection;Cancer Prognosis;cancer therapy;carcinogenesis;Clinical Trials;Collaborations;Colon Carcinoma;Communities;community engagement;Computer software;Data;data access;data integrity;Data Pooling;Data Provenance;data repository;data submission;Decentralization;Deposition;Development;Diet;driving force;Ecosystem;Educational process of instructing;Educational workshop;Ensure;Environment;Environmental Exposure;epigenomic profiling;Etiology;Galaxy;Genes;Genetic Markers;Genotype;graphical user interface;Health;Human;Human body;Human Microbiome;Immune;Immune system;Improve Access;improved;Individual;Informatics;insight;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant stomach neoplasm;Metabolic;metabolome;metabolomics;Metadata;metagenome;Metagenomics;metaproteomics;metatranscriptome;metatranscriptomics;Methods;microbial;microbiome;microbiome research;microbiota;microorganism;Modeling;Multiomic Data;multiple omics;neoplasm resource;Online Systems;pathogenic microbe;pathogenic virus;Plug-in;preference;Prognosis;Publications;R programming language;repository;Reproducibility;Research;Research Personnel;Resources;Ribosomal RNA;Role;Running;Sampling;Series;skills;Smoking Status;success;symposium;Systems Analysis;Taxonomy;Technology;The Cancer Genome Atlas;tool;Translating;Treatment Efficacy;Work

PROJECT_TITLE: Advanced Development of Informatics Technologies for Cancer Research and Management (U24 Clinical Trial Optional)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Genetics;Health Services;Patient Safety;Precision Medicine;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Smoking is a leading cause of premature death, causing more than half of all cancer deaths. However, tobacco treatment is often not provided and not highly effective in primary care. New evidence suggests that a precision treatment approach to motivate and guide treatment based on personal genetic and metabolic markers could improve treatment uptake and quit success. This study will test the impact of a multilevel precision treatment intervention on improving tobacco treatment and health outcomes in primary care.

PI_NAMEs: CHEN, LI-SHIUN  (contact);RAMSEY, ALEX TAYLOR

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Adoption;arm;Behavior;behavior change;Behavioral Mechanisms;Benefits and Risks;Biochemical;Biological;Biological Markers;Cessation of life;Clinic;clinical practice;Communication;cost;Data;Drug Prescriptions;Effectiveness;Electronic Health Record;evidence base;Evidence based treatment;Expectancy;Feedback;Future;Genes;Genetic;Genetic Markers;Genetic Risk;Genomic medicine;Genomics;Genotype;Health;Healthcare Systems;implementation efforts;implementation evaluation;implementation outcomes;improved;Individual;innovation;interest;Intervention;Link;Malignant Neoplasms;Measures;Metabolic;Metabolic Marker;Metabolism;Modeling;Motivation;Nicotine;nicotine replacement;Nicotinic Receptors;novel strategies;Outcome;Patient Compliance;Patients;personalized intervention;Pharmaceutical Preparations;Physicians;Population;Practice Guidelines;precision medicine;Precision therapeutics;premature;Primary Care;Provider;Public Health Informatics;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;receptor function;Recommendation;Research;Risk;Safety;secondary outcome;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;standard care;success;Testing;Theoretical Domains framework;Theory of Change;Tobacco;tool;Translating;treatment as usual;Treatment Effectiveness;treatment optimization;treatment response;uptake;varenicline;Variant;Withdrawal;Work

PROJECT_TITLE: A multilevel intervention to personalize and improve tobacco treatment in primary care

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative  The present collaborative studies will evaluate and optimize a novel prodrug-based delivery strategy for tumor-specific pharmacotherapy of neuroendocrine cancers. We will focus on the prodrug design as a tool for achieving high selectivity and potency of the anticancer therapy, while protecting normal tissues from exposure to toxic drug levels. The results of this project will facilitate the development, translation and clinical implementation of prodrugs targeted to tissue-specific cell uptake mechanisms as delivery systems for treating high-risk neuroblastoma and other aggressive solid tumors currently lacking effective treatment options.

PI_NAMEs: BRODEUR, GARRETT M;CHORNY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acute;Address;Adverse effects;Affinity;analog;Antineoplastic Agents;antitumor effect;Automobile Driving;Biodistribution;cancer cell;cancer therapy;Catecholamines;Cell Cycle;cell injury;cell killing;Cell Line;Cells;Chemistry;Chemoresistance;Chemosensitization;Child;Childhood Extracranial Solid Tumor;Clinical;clinical implementation;clinical translation;clinically relevant;combat;comparative;deiodination;design;Development;Disease;disease model;disorder risk;Dose;drug action;Drug Delivery Systems;Drug usage;effective therapy;effectiveness evaluation;Evaluation;Exhibits;experimental study;Exposure to;Genetically Engineered Mouse;Goals;Growth;high risk;Histone Deacetylase Inhibitor;improved;irinotecan;Life;Ligands;Link;Maximum Tolerated Dose;Mediating;metaiodobenzylguanidine;Metastatic Pheochromocytoma;mimetics;Modeling;Molecular;Molecular Target;Multi-Drug Resistance;MYCN gene;Neoplasm Metastasis;Neoplasms;neoplastic cell;Neural Crest;Neuroblastoma;neuroblastoma cell;neuroendocrine cancer;Neuroendocrine Cell;Neuroendocrine Tumors;noradrenaline transporter;Norepinephrine;Normal tissue morphology;novel;novel strategies;Organ;Outcome;pediatric patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;Polymers;precursor cell;Primary Neoplasm;Process;Prodrugs;programs;Radiation therapy;Radioactive;Radiopharmaceuticals;Refractory;refractory cancer;Refractory Disease;Relapse;Research;response;Retinoids;reuptake;Role;Safety;Second Primary Cancers;Series;small molecule;SN-38;Solid Neoplasm;Structure;Structure-Activity Relationship;System;targeted delivery;Targeted Radiotherapy;Testing;Therapeutic;therapeutic effectiveness;Time;Tissues;tool;Topoisomerase-I Inhibitor;Toxic effect;Translating;Translations;Treatment outcome;treatment strategy;tumor;Tumor Tissue;Type I DNA Topoisomerases;uptake;Validation;Water;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Prodrugs targeting norepinephrine transporter for dual-selective therapy of refractory neuroblastoma

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Genetics

ORG_CITY: SAN JOSE

ORG_DEPT: BIOLOGY

ORG_NAME: SAN JOSE STATE UNIVERSITY

PHR: PROJECT NARRATIVE A fundamental question in evolutionary biology is how the genetic basis of adaptation changes depending on the rate of environmental change. This study proposes to examine patterns of mutation fixation and mutational effects in viral populations that experienced a sudden or gradual increase in temperature, and to compare these patterns to expectations from existing theoretical models. The work is important for refining the theoretical models, and for identifying selective pressures and constraints that could be used to predict or control future viral evolution.

PI_NAMEs: SINGHAL, SONIA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Effects of The Rate of Environmental Change on Mutational Patterns and Evolutionary Constraints


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: NEUROLOGY

PHR: While the development of many new neural recording technologies has led to much excitement, it has created a huge gap between our ability to collect data and our ability to deeply understand it. More interpretable machine learning tools are necessary for understanding neural function in health and neurological disease, to one day develop curative interventions. The goal of this research is to develop interpretable machine learning models and apply them to understand how brain areas interact with each other and how they control muscle activity during a wide range of movements.

PI_NAMEs: GLASER, JOSHUA I (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Area;Award;Behavior;Biology;Brain;brain computer interface;Brain region;Collaborations;Communication;Communities;Complex;complex data;Computational Technique;Computing Methodologies;cortex mapping;curative treatments;Data;Data Set;data structure;Development;experience;experimental study;explainable machine learning;flexibility;Goals;Health;improved;insight;Intramuscular;Knowledge;laboratory experiment;Lead;Link;Macaca;Machine Learning;machine learning method;machine learning model;Maps;Methods;Modeling;Modernization;Motor;Motor Activity;motor control;Motor Cortex;motor impairment;Motor Neurons;Motor output;Movement;Muscle;Nervous System Disorder;neural;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences;novel;Output;Performance;Phase;Population;Posture;Research;Research Personnel;Rest;Side;simulation;Spinal;Spinal Cord;Structure;Technology;Testing;Time;tool;Training;Work

PROJECT_TITLE: Interpretable machine learning for understanding the neural control of movement

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Children with mild bilateral hearing loss (MBHL) do not receive hearing aids as often as peers with greater degrees of hearing loss due to a lack of clinical tools to assess their listening difficulties. This research proposal would address this critical need by developing clinical novel clinical assessment and outcome measures for children with MBHL. The result will be improved communication, academic, and social outcomes for this underserved population.

PI_NAMEs: MCCREERY, RYAN W. (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 8 year old;Acoustics;Address;Area;Audiology;Auditory;Bilateral Hearing Loss;Calibration;Child;Childhood;childhood hearing loss;Clinical;Clinical assessments;clinical outcome measures;Clinical Protocols;Collaborations;Communication;Cueing for speech;Cues;Data;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Distant;Ear;Early identification;Effectiveness;evidence base;experience;External auditory canal;Failure;Goals;Hearing;Hearing Aids;hearing impairment;Hearing Tests;improved;Individual Differences;Intervention;Knowledge;Language;Learning;Masks;Measurement;Measures;Methods;Monitor;Noise;normal hearing;novel;Outcome;Outcome Measure;peer;Population;recruit;Research;Research Personnel;Research Proposals;Risk;Science;segregation;service delivery;skills;social;Social outcome;sound;Source;Speech;speech in noise;speech recognition;Techniques;Testing;tool;Uncertainty;Underserved Population;Validation;Validity and Reliability;Work

PROJECT_TITLE: DEVELOPING EVIDENCE-BASED CLINICAL TOOLS FOR MANAGING MILD HEARING LOSS IN CHILDREN


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE Inflammation precedes neurodegeneration in glaucoma and may continue to drive it even in the presence of adequate pressure control yet no treatments exist to protect the retina from pressure-induced inflammation. To overcome this challenge, we propose to identify the glial mechanotransducers, define their role in the inflammation and neurodegeneration and mitigate their pathological roles through selective gene ablation. This work is hoped to pave the way for targeted interventions based on early diagnosis and treatment of pressure induced pathologies within the retina.

PI_NAMEs: KRIZAJ, DAVID  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Astrocytes;Automobile Driving;axon injury;Biological Assay;Biomechanics;Blindness;Calcium;calcium indicator;Calcium Signaling;cell injury;Cell model;Cell Physiology;Cell Survival;cell water;Cells;Cellular Stress;Central Nervous System;chemokine;Chronic;Closure by clamp;conditional knockout;cytokine;Dendrites;diagnostic strategy;Early Diagnosis;Early treatment;Electrophysiology (science);experimental study;Family;ganglion cell;gene gun;Generations;Genes;Genetic;Glaucoma;Gliosis;Goals;Homeostasis;hypertensive;Hypertrophy;Image;Immunophenotyping;In Vitro;Induced Neurons;Inflammation;Inflammatory;inhibitor;Injury;innovation;Intervention;Ion Channel;Ions;knock-down;Knockout Mice;Knowledge;Lead;Link;Luciferases;luciferin;macroglia;mechanical drive;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Membrane;Methods;Microglia;Molecular;Molecular Target;mouse model;Muller's cell;multidisciplinary;Nerve Degeneration;Neuroglia;neuroinflammation;neuronal circuitry;Neuronal Injury;Neurons;Neuropathy;neuroprotection;neurotransmission;normotensive;novel diagnostics;Pathologic;Pathology;Pathway interactions;Peripheral Nervous System;Permeability;pharmacologic;Pharmacology;Physiologic Intraocular Pressure;Piezo 1 ion channel;Piezo ion channels;pressure;prevent;Process;Property;receptor;Regulation;Research;response;Retina;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;RNA;Role;Signal Transduction;skeletal disorder;small hairpin RNA;Speed;Stress;stressor;Stretching;Swelling;Synapses;Testing;Tissues;Transcript;Transfection;Transgenic Organisms;Traumatic Brain Injury;treatment strategy;TRP channel;two photon microscopy;Vanilloid;Work

PROJECT_TITLE: Cellular and Molecular Mechanisms that Contribute to Pressure-Induced Retinal Inflammation and Pathology

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE We will comprehensively investigate the mechanisms underlying the contribution of the functional SNPs and regulatory elements on the CDKN2A/B locus to the pathogenesis and susceptibility of atherosclerosis using our newly developed high throughput techniques. We will reveal the mechanisms that control cellular senescence via regulating CDKN2A/B genes. Our goal is to identify unifying biochemical pathways linked to age-related conditions for drug targeting.

PI_NAMEs: FINKEL, TOREN ;LI, GANG  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: 9p21.3;Address;Age;age related;age-related disease;Aging;Allelic Imbalance;Atherosclerosis;Binding;Binding Proteins;Biochemical Pathway;Biological;Biological Assay;Biological Process;Cardiovascular Diseases;CDKN2A gene;Cell Aging;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;cell type;chromatin immunoprecipitation;Chromosomes;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor 2A;Disease;Disease Progression;Disease susceptibility;DNA;Drug Targeting;Electrophoretic Mobility Shift Assay;Elements;Endothelial Cells;functional genomics;Genes;Genetic;genetic regulatory protein;Genome;genome wide association study;genomic locus;Genomic Segment;Genomics;Goals;Guillain Barré Syndrome;Human;In Vitro;Incidence;Lead;Left;life span;Link;Linkage Disequilibrium;Luciferases;Macrophage;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Methods;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Extract;Pathogenesis;Predisposition;pro-aging;Proteins;Qualifying;Regulatory Element;Reporter;risk variant;RNA Interference;Role;Single Nucleotide Polymorphism;Smooth Muscle Myocytes;Specific qualifier value;Techniques;Untranslated RNA;Western Blotting

PROJECT_TITLE: Comprehensive functional genomic analysis of the multi-disease associated CDKN2A/B locus

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Radiation Oncology

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This proposal will develop methods to quantify the interaction of radiation with the immune system, particularly the blood (i.e., circulating lymphocytes). We envision that future treatment planning in radiation oncology will treat lymphatic nodes and the blood as organs at risk and include them in the treatment optimization process so as to influence the level at which the radiation treatment impacts the immune system of the patient. Clinical trials can be properly designed only if the dose to circulating lymphocytes can be accurately quantified. Our tools will ultimately allow this for both pre-clinical and clinical research.

PI_NAMEs: BOLCH, WESLEY E;PAGANETTI, HARALD  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Adolescent;Adult;Adult women;Angiography;biomathematics;Blood;Blood Circulation;Blood flow;Blood Vessels;Blood Volume;cell killing;Clinical Research;Clinical Trials;Clinical Trials Design;Combination immunotherapy;Communities;Corrosion Casting;cortical bone;design;Dose;dosimetry;ex vivo imaging;Female;Four-dimensional;Fractionation;Future;Goals;Immune response;Immune system;in vivo imaging;innovation;irradiation;Laboratory mice;Libraries;lymph nodes;Lymphocyte;lymphoid organ;male;Male Adolescents;Marrow;Measures;Methodology;Methods;microCT;Modality;Modeling;mouse model;Mus;Nature;novel;Organ;Patient Representative;Patients;Population;pre-clinical research;preclinical study;process optimization;Radiation;Radiation Dose Unit;Radiation Interaction;Radiation Oncology;Radiation therapy;Research;Risk;Rodent;simulation;Site;skeletal;Structure;Time;tool;treatment optimization;treatment planning;Treatment Protocols

PROJECT_TITLE: Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune system

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Primary Health Care;Substance Misuse

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Stagewise Implementation-To-Target – Medications for Addiction Treatment (SITT-MAT) is an adaptive implementation strategy trial with 72 community health care organizations within a state public health system. This is a revised application featuring an innovative approach to examining outcomes of a stepped approach to implementation and sustainment of medications for opioid use disorder. The impact, both for implementation science and for the public health benefit, can be substantial.

PI_NAMEs: FORD, JAMES H;MCGOVERN, MARK P (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Academy;Acceleration;Accident and Emergency department;addiction;Address;Adherence;Adoption;arm;authority;Binding;Biometry;Black Box;Budgets;Buprenorphine;care systems;Caring;Characteristics;combat;Communities;Community Healthcare;contextual factors;coping;cost;COVID-19 pandemic;Decision Making;Dedications;design;Diagnosis;Discipline;Disparity;Dissemination and Implementation;economic evaluation;Educational workshop;Effectiveness;Engineering;Ensure;Epidemic;evidence base;Evidence based intervention;Evidence based practice;Evidence based treatment;FDA approved;Feedback;Funding;global health;Goals;Growth;Health;Health Benefit;health care service organization;Health Services Research;Health system;Healthcare;Hospitals;Hour;implementation research;implementation science;implementation strategy;implementation trial;Improve Access;improved;innovation;Intervention;Investments;Lead;Maintenance;Measurement;Measures;Mediator;Medical;medical specialties;medication for opioid use disorder;Medication Management;Methods;Modeling;Modification;Monitor;Naltrexone;National Institute of Drug Abuse;Nature;Neighborhood Health Center;Normalcy;novel therapeutics;opioid epidemic;opioid use disorder;Outcome;overdose death;Overdose reduction;pandemic disease;patient engagement;Patients;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Policies;prescription opioid;Prevention;Primary Care;Procedures;process improvement;programs;Protocols documentation;Provider;Public Health;Quarantine;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;Reporting;Research;Research Personnel;research study;response;scale up;Site;standardize measure;Strategic Planning;Substance Use Disorder;substance use treatment;System;Translations;treatment organization;treatment program;treatment services;trial design;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;videoconference;Washington;Work

PROJECT_TITLE: Stagewise Implementation-To-Target- Medications for Addiction Treatment (SITT-MAT)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Although Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) affect a large and growing number of Americans, the social determinants of AD/ADRD are not well understood. The proposed research leverages data from the Health and Retirement Study, a nationally representative panel survey of older U.S. adults, to investigate the consequences of patterns and trends in education for sex/gender disparities in AD/ADRD. Results will clarify whether gender inequality in education contributes to women’s greater burden of AD/ADRD, with significant implications for social, economic, and health policy and practice.

PI_NAMEs: ZACHER, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Adult;Affect;Aging;aging demography;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Automobile Driving;Behavior;Behavioral;Biological;Biology;Brain Pathology;career;Characteristics;Cognitive;cognitive reserve;college;comparative;Delayed Memory;Disparity;Disproportionately impacts women;Economic Policy;Economics;Education;Educational Status;Fostering;Future;Gender;gender disparity;Gene Expression;Gerontology;Goals;Grant;Health;Health and Retirement Study;health data;Health Policy;Health Services;High Prevalence;high school;higher education;Hormones;Human;Impaired cognition;Inequality;Knowledge;Learning;Life Cycle Stages;Link;Longevity;Mediating;medical schools;Medicine;Memory Loss;men;Mentored Research Scientist Development Award;Mentors;Methods;mid-career faculty;Neurologic;Neurology;Occupational;Occupations;Pattern;Policies;Population;population health;Population Study;Prevalence;Prevention;professor;Psyche structure;Psychiatry;Recording of previous events;Research;Research Personnel;Resources;Respondent;Risk Reduction;Role;Schools;segregation;sex;Sex Characteristics;sex disparity;Sex Education;sex variable;Shapes;skills;social;social determinants;social factors;social implication;Social Policies;Social Sciences;Sociology;Structure;Surveys;Time;Time trend;Training;trend;Universities;Variant;Woman;Work

PROJECT_TITLE: The Contributions of Education to Sex/Gender Disparities in Alzheimer's Disease and Alzheimer's Disease-Related Dementias

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Microbiome;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE While the resident microbiota has been extensively characterized in many parts of the human body, such as the gut, the ocular surface microbiome is relatively understudied. This is in part due to the unique challenges of characterizing a broad range of organisms in specimens that have low microbial biomass, such as those collected from the ocular surface. Here, we describe the systematic optimization of sample processing methods, validation of computational tools, and longitudinal characterization of the composition and viability of organisms comprising the healthy ocular surface microbiome.

PI_NAMEs: ENSIGN, LAURA  (contact);KARAKUS, SEZEN ;SALZBERG, STEVEN L.

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Address;Air;analytical method;analytical tool;Anesthetics;Biomass;Biopsy;Body Surface;Brain;Cell Culture Techniques;Cerebrospinal Fluid;Clinic;Clinical;Clinical assessments;cohort;Collection;Communities;Computer software;computerized tools;Computing Methodologies;Data Set;Dedications;Detection;Development;Diagnosis;Diagnostic tests;Disease;DNA;DNA analysis;DNA Sequence;Drops;Enrollment;Environment;Epithelium;ethnic diversity;experience;Exposure to;Eye;Eye diseases;face mask;female reproductive tract;Fluorescent in Situ Hybridization;functional genomics;Geography;Glean;Guidelines;Health;Homeostasis;Hospitals;Human body;Human Resources;Infection;Inferior;Inflammation;Laboratories;Left;metagenome;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microbiome composition;microbiota;microorganism;Mucous Membrane;multidisciplinary;next generation sequencing;Noise;novel;Nucleic Acids;ocular microbiome;ocular surface;open source;Organism;Paraffin Embedding;Participant;pathogen;Pathogenicity;patient population;Polymerase Chain Reaction;Procedures;Process;protocol development;Protocols documentation;Resources;RNA Sequences;Saline;sample collection;Sampling;Signal Transduction;Site;Skin;socioeconomics;Software Tools;Source;Specimen;Specimen Handling;standard of care;Standardization;Sterility;Surface;Swab;Techniques;Tissues;tool;Validation;Visit;Work

PROJECT_TITLE: Development of standardized resources for characterization of the resident ocular surface microbiome.


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences;Rehabilitation

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of this research is to better understand the efferent auditory system’s role in speech-in-noise perception by: 1) improving methods used to study it and 2) evaluating its function in normal-hearing adults with and without speech-in-noise deficits. The outcomes of this research can be used to: 1) create clinical assessments and targeted treatments for individuals with severe difficulties understanding speech-in-noise and 2) create biologically-inspired noise reduction algorithms for hearing aids and cochlear implants that are based on neural processing strategies in the normal auditory system.

PI_NAMEs: SMITH, SPENCER  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Academic achievement;Acoustic Nerve;Active Listening;Adult;Algorithms;Amplifiers;Animals;Attention;attentional modulation;Auditory;auditory pathway;Auditory system;base;Biological Assay;Biophysics;Brain;brain computer interface;Brain Stem;Clinical;Clinical assessments;Cochlea;Cochlear Implants;Cognitive;Communication impairment;Contralateral;Development;experimental study;Frequencies;Glean;Goals;Hearing Aids;Hearing Tests;Human;Impairment;improved;Individual;Labyrinth;Lesion;Light;Measurement;Measures;Mechanics;Medial;Methods;Modeling;Nervous System;neural;neural circuit;Neurobiology;neurophysiology;Noise;noise perception;normal hearing;otoacoustic emission;outcome disparities;Outcomes Research;Outer Hair Cells;Patients;Perception;Performance;personalized diagnostics;Physiological;Play;predictive test;Proxy;Reflex action;Research;Research Project Grants;response;Role;Signal Transduction;Site;social;Speech;speech in noise;Speech Perception;speech processing;standard measure;Statistical Models;Stimulus;Structure of tractus olivocochlearis;System;targeted treatment;Time;treatment strategy;Vocation;Withdrawal;Work

PROJECT_TITLE: Efferent Auditory Measurements during Continuous Attended Speech in Normal Hearing Listeners With and Without Speech-in-Noise Deficits

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative We do not understand how chromosome folding inside the nucleus influences gene transcription. We propose to manipulate DNA loop extrusion by cohesin protein using new genetic tools in embryonic stem cells. We will provide novel insight into the fundamental principles that link chromosome structure to genetic activity.

PI_NAMEs: NORA, ELPHEGE-PIERRE JULIEN (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Architecture;Binding Sites;Biochemical;Biological Assay;Cell Differentiation process;Cell Nucleus;Chromatin;Chromatin Fiber;Chromatin Loop;Chromosome Structures;Chromosomes;cofactor;cohesin;Communication;Complex;Coupled;developmental disease;Disease;DNA;embryonic stem cell;Engineering;Enhancers;epigenome;epigenomics;Etiology;Future;Gene Combinations;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Goals;human disease;insight;interest;Investigation;Link;Malignant Neoplasms;Modality;Molecular;Mouse Embryonic Stem Cells;Mutation;novel;novel strategies;Pathway interactions;Process;promoter;Proteins;Reporter;Research;Role;tool;transcription factor;Transcriptional Regulation

PROJECT_TITLE: Investigating the role of genome folding in transcriptional regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative This work will bolster our understanding of epicardial-myocardial signaling and the role of the extracellular matrix in modulating cell behavior in the developing heart. The clinical relevance of this work lies in the application of epicardial cells to enhance the pump function of a perfusable, chambered, human cardiac tissue model that will be ideal to study the impact of cardiac disease and therapeutics on pressure-volume dynamics, stroke work, and ejection fraction. In the future, this living, human muscle pump generated in a dish might be used to restore cardiac function in patients with heart disease.

PI_NAMEs: OGLE, BRENDA M (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;3D Print;Automobile Driving;Behavior;Biochemical;Bioreactors;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;Cardiovascular system;Catheters;cell behavior;Cell Density;Cell secretion;cell type;Cells;Clinical;clinically relevant;Complex;Coronary;Coupling;Cues;Deposition;design;Development;Developmental Process;Devices;Disease;disease model;drug testing;Drug usage;EFRAC;Electric Stimulation;Embryo;Environment;Epicardium;epithelial to mesenchymal transition;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblast Growth Factor;Fibroblasts;Future;Generations;Genes;Growth Factor;Heart;heart cell;Heart Diseases;heart function;Human;human induced pluripotent stem cells;human model;human tissue;implantation;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;Insulin-Like Growth Factor II;Integrins;interest;Interleukin-2;Knowledge;Link;Mass Spectrum Analysis;Mechanical Stimulation;Medicine;migration;millimeter;Modeling;Morphogenesis;Morphology;Mus;Muscle;Myocardial;Myocardium;next generation;novel;Organoids;Output;Paracrine Communication;Patients;Phenotype;Play;Pluripotent Stem Cells;pressure;Pressure Transducers;Process;Proliferating;Protein Secretion;Proteins;Proteomics;Pump;Regulation;Role;Sarcomeres;Signal Transduction;Smooth Muscle Myocytes;stem cells;Stroke;Structure;Supporting Cell;Testing;Therapeutic;Thick;Time;Tissue Engineering;Tissue Model;Tissues;Vascular Smooth Muscle;Ventricular;Work

PROJECT_TITLE: Epicardial regulation of cardiomyocyte function via modulation of extracellular signals: toward a model of human muscle pump function

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE: Opioid use disorder causes persistent epigenomic changes in brain reward regions that contribute to drug seeking behavior, but we currently do not have a way to access these epigenomically altered cells selectively. The proposed work develops a novel viral approach that leverages the unique epigenomic environment in animal models of opioid use disorder to gain selective access to and control of the cells that drive drug seeking behavior.

PI_NAMEs: RENTHAL, WILLIAM RUSSELL (contact)

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: addiction;Affect;Animal Model;Bar Codes;Behavior;brain reward regions;Cells;Cessation of life;Chromatin;Chronic;chronic pain patient;Development;drug abstinence;Drug abuse;Drug Prescriptions;drug seeking behavior;Elements;Enhancers;Environment;epigenomics;Exposure to;gene conservation;Gene Expression;Genes;Genetic;Genomic Segment;improved;in vivo;innovation;Knowledge;Label;Libraries;Life;Maps;Medical Care Costs;Modeling;Morphine;Mus;Nature;Neurons;novel;novel strategies;novel therapeutic intervention;Nucleus Accumbens;Opioid;opioid use;opioid use disorder;pain relief;Patients;Population;Rapid screening;Refractory;Regulatory Element;Relapse;Resolution;Respiratory Failure;Self Administration;side effect;single nucleus RNA-sequencing;Stimulus;Technology;Transgenic Mice;Translating;United States;Viral;Work

PROJECT_TITLE: Epigenomic labeling of cells that drive drug abuse behavior


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: NARRATIVE The cones in the fovea face extremely high photon fluxes throughout our lives and it is not clear how they escape a complete depletion of the visual pigments in bright sun light. The experiments in this proposal will elucidate the contribution of recently discovered pigment regeneration pathways in the mouse neural retina to dark adaptation and maintenance of light sensitivity in the human macular cones. A long-term goal of these studies is to generate new knowledge about the function of the photoreceptors and their interactions with Müller glia and retinal pigment epithelium in the human macula in healthy eyes as well those affected by macular dystrophies such as Age- Related Macular Degeneration.

PI_NAMEs: VINBERG, FRANS  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Affect;Age;Age related macular degeneration;Aging;Animal Model;Animals;Automobile Driving;Autopsy;Biochemical Reaction;Biological Models;Biology;Blindness;Cells;Collaborations;Color Visions;Cone;Critical Pathways;Dark Adaptation;Darkness;Disease;disorder of macula of retina;Dryness;effective therapy;Elderly;Electrodes;Electrophysiology (science);Electroretinography;Environment;experience;experimental study;Eye;Eye Banks;Face;fovea centralis;Geographic Locations;Goals;Health;Hour;Human;human disease;improved;Individual;insight;Isomerism;Kinetics;Knowledge;Light;Light Adaptations;Lighting;macula;macular dystrophy;Maintenance;Measures;Mediating;Methods;Molecular;Muller's cell;Mus;National Eye Institute;Natural regeneration;Neural Retina;nonhuman primate;Organ;Organ Donor;Panthera leo;Pathogenesis;Pathway interactions;Peripheral;Photons;Photophobia;Photoreceptors;Pigment Epithelium;Pigments;prevent;Primates;Process;Protocols documentation;Reading;Regenerative pathway;Research;response;Retina;Retinal Cone;Retinal Pigments;Rod;Rodent;Role;Salamander;Sampling;Strategic Planning;Structure of retinal pigment epithelium;Suction;Sunlight;Techniques;Testing;Time;Tissue Donors;tissue preparation;Tissues;Transportation;Utah;Vertebrate Photoreceptors;Vision;Vision research;visual cycle;Work

PROJECT_TITLE: Pigment Regeneration Mechanisms in the Human Retina

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Biotechnology;Precision Medicine

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE The proposed research will be focused on technology development for ultra-high sensitivity deep proteomic analysis of limited biological and clinical samples. Comprehensive proteome characterization of such samples at the level of digests, intact proteoforms, native non-covalent protein complexes, and protein interactions is presently an insurmountable challenge in bioanalytical research. The proposed technology offers an unprecedented opportunity for expanding our knowledge of molecular mechanisms of disease processes and identifying new paths toward the discovery of diagnostic and prognostic biomarkers using minuscule sample amounts. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page

PI_NAMEs: IVANOV, ALEXANDER R. (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Biological;Biological Models;Biological Process;Biomedical Research;Biopsy;Cancer cell line;Cell Differentiation process;Cells;Characteristics;Clinical;clinically relevant;Complex;data acquisition;Data Analyses;Development;Diagnostic;diagnostic biomarker;Diagnostics Research;Disease;Hematopoietic stem cells;Immune;Individual;innovation;insight;Knowledge;Ligands;liquid biopsy;Liquid substance;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Methods;Microscopic;Molecular;Neoplasm Circulating Cells;new therapeutic target;novel;novel strategies;Peptides;personalized medicine;Pharmaceutical Preparations;Phase;Play;Population;Post-Translational Protein Processing;Preparation;Process;prognostic;Prognostic Marker;protein complex;Proteins;Proteome;Proteomics;public health relevance;Research;research and development;response biomarker;Role;Sampling;screening;Specimen;STAT3 gene;Techniques;Technology;technology development;therapeutic biomarker;Therapeutic Studies;therapeutic target;transcription factor;X-Ray Crystallography;yeast two hybrid system;Yeasts

PROJECT_TITLE: Robust ultra-high sensitivity proteomic technologies for limited samples

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: TEMPE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

PHR: RELEVANCE (See instructions): Integration of different sensory modalities is a common cognitive capability and a foundation of  communication processes. Inability to properly process simultaneous channels of sensory inputs may lead  to symptoms expressed by patients of autism disorder spectrum (ASD). Better understanding of the  mechanisms and brain dynamics underlying multisensory integration will facilitate understanding  communication processes in healthy subjects as well as the underpinnings of communication disorders.

PI_NAMEs: BAZHENOV, MAKSIM V;LEI, HONG  (contact);PATEL, MAINAK JIGNESH

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Affect;Anatomy;Animal Behavior;Animals;Architecture;Arithmetic;ASD patient;Auditory;Bees;Behavior;Behavioral;Benchmarking;Biological Models;Brain;Capuchin Monkey;Chemicals;Classification;Code;Cognitive;Collaborations;Color;Communication;Communication impairment;Complex;computational neuroscience;Computer Models;coping;Data;Data Analyses;Defect;Dependence;design;Diagnosis;Electrophysiology (science);Environment;Environmental Wind;experience;experimental study;Flying body movement;Food;Foundations;Fruit;Future;in vivo;Insecta;Instruction;Intrinsic drive;Lobe;Machine Learning;machine learning algorithm;Measures;mechanical signal;Mechanics;Modality;Modeling;multimodality;multisensory;Nervous System;network models;neural;Neurons;novel;nutrition;Nutritional;odor discrimination;Odors;olfactory bulb;Pathology;Physiologic pulse;Process;Reporting;Research;response;Role;Scheme;Sensory;sensory input;sensory integration;Services;Signal Transduction;Smell Perception;Source;Speed;Stimulus;Stream;Study models;success;Symptoms;System;Tactile;Testing;Time;Urticaria;Visual;Work

PROJECT_TITLE: CRCNS: Switching antennal lobe dynamic regime via olfactory and mechanical signal


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Syphilis is a bacterial infection that can lead to devastating birth outcomes in pregnant women. The Syphilis in Pregnancy Study (SIPS) was designed to improve syphilis diagnostic testing in women and infants so fewer infections are missed. The study will also measure the immune response to syphilis in women and infants before and after penicillin treatment to identify markers of protection to help guide future vaccine studies.

PI_NAMEs: DIONNE, JODIE ANN (contact);GIACANI, LORENZO ;MUBIANA-MBEWE, MWANGELWA

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Acceleration;adaptive immune response;Address;adverse birth outcomes;adverse outcome;Africa;Aftercare;Age;Animals;Antibodies;antibody diagnostic;antigen-specific T cells;Antigens;Area;Bacterial Infections;Binding;Biological Assay;biomarker identification;Birth;Blood specimen;Cameroon;case finding;CD4 Positive T Lymphocytes;Childhood;Clinical;co-infection;cohort;Communicable Diseases;Complement;Congenital Syphilis;Data;Decidua Basalis;design;Detection;Development;Diagnosis;Diagnostic;diagnostic algorithm;Diagnostic tests;Disease;Enrollment;fetal;Fetus;Flow Cytometry;follow-up;Future;Generations;Genome;genome sequencing;genomic data;Gestational Age;Goals;High Prevalence;HIV;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunoglobulin G;Immunoglobulin M;Immunology procedure;improved;Income;Infant;Infection;infection rate;insight;Integration Host Factors;International;Kinetics;Knowledge;Laboratories;Lesion;Live Birth;Low Birth Weight Infant;Maternal antibody;Maternally-Acquired Immunity;Measures;Mediating;Medical;Modeling;Molecular;Molecular Biology;Molecular Diagnostic Testing;molecular diagnostics;Molecular Immunology;multidisciplinary;Natural History;Neonatal Mortality;neonate;novel;Oral;Outcome;parity;Participant;Pathogenesis;Penicillins;Performance;Perinatal;Peripheral Blood Mononuclear Cell;Placenta;placental transfer;Pregnancy;pregnant;Pregnant Women;Premature Birth;Prevalence;prevent;Prospective, cohort study;Proteomics;Public Health;Reaction;Recording of previous events;reproductive;response;Role;sample collection;Sampling;Sampling Studies;screening;Serology;Serum;Specificity;Spontaneous abortion;stillbirth;success;Swab;Syphilis;syphilis vaccine;T cell response;T-Lymphocyte;Testing;Time;transmission process;treatment response;Treponema pallidum;Umbilical Cord Blood;United States;vaccine candidate;vaccine development;vaccine trial;Vertical Transmission;Virulence Factors;whole genome;Woman;Zambia

PROJECT_TITLE: Syphilis in Pregnancy Study (SIPS): Molecular Diagnostics and Maternal and Infant Immune Response to Infection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The research program is relevant to public health because its overarching aim is to determine the developmental impact of mild to severe hearing loss on reading comprehension. More specifically, we will study how individual differences in early auditory access and oral language skills are associated with variability in growth trajectories for reading comprehension. This research program fulfills the mission of the NIH to improve health through research because it will provide evidence on the effect of auditory-linguistic experience on reading development and provide empirical support for clinical recommendations for intervention for children with permanent hearing loss.

PI_NAMEs: WALKER, ELIZABETH A. (contact)

PROJECT_TERMS: Adolescent;Age;Auditory;Bilateral;Child;Childhood;Clinical;Cognitive;cohort;comprehension skill;Data;deaf;Development;early childhood;Early Intervention;education planning;elementary school;Equation;Evidence based intervention;experience;Foundations;fourth grade;Future;Goals;Growth;hard of hearing;Health;Hearing;Hearing Aids;hearing impairment;Heterogeneity;high school;human old age (65+);improved;Individual Differences;infancy;Instruction;Intervention;Intervention Studies;Investigation;junior high school;kindergarten;Knowledge;Language;language comprehension;Language Delays;Language Development;language outcome;Lead;Learning;Linguistics;listening comprehension;longitudinal design;Longitudinal Studies;Mediating;Mediation;meetings;Mission;Modeling;Modernization;Morphology;Motivation;normal hearing;Nursery Schools;Oral;Outcome;permanent hearing loss;Play;Poverty;Process;programs;prospective;prospective test;psychosocial;Psychosocial Factor;Public Health;Qualifying;Reader;Reading;reading ability;reading comprehension;reading difficulties;Recommendation;Research;Research Design;Residual state;Risk;Role;Route;Secondary Schools;Sensory;service delivery;Signal Transduction;skills;Source;Specific qualifier value;Speech;Testing;Text;Theoretical model;Time;twelfth grade;United States National Institutes of Health;Variant;Vocabulary;Work

PROJECT_TITLE: Factors associated with reading comprehension in adolescents who are hard of hearing

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NORTHRIDGE

ORG_NAME: CALIFORNIA STATE UNIVERSITY NORTHRIDGE

PHR: Adolescents impacted by household incarceration and associated stressors are at increased risk for compromised school and mental and behavioral health outcomes. SHARE evaluates a primary prevention program for youth that embeds SEL competencies in novel artistic self- expression and community engagement activities to strengthen protective factors known to promote healthy adolescent development and resilience. SHARE will advance scientific understanding of adolescent risk and resilience processes and expand the evidence-base of effective prevention programming for vulnerable youth.

PI_NAMEs: FORSTER, MYRIAM  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Academic achievement;ACE2;Achievement;Adolescent;Adolescent Development;Adult;adverse childhood events;Affect;Alaska;Anxiety;anxiety symptoms;Behavior;behavioral health;California;Caring;Child;children of color;Communities;community engagement;comparison group;Competence;coping;Creativeness;Criminal Justice;Data;Decision Making;depressive symptoms;design;Development;Disadvantaged;Divorce;Dose;Educational Curriculum;emerging adult;Emotional;Employment;ethnic identity;Ethnic Origin;Etiology;Evaluation;Evaluation Research;Event;evidence base;experience;Exposure to;Family;Family member;Fostering;Funding;Gender;General Population;Goals;Growth;Health;high school;Household;Impairment;Imprisonment;Intercept;intimate partner violence;Joints;Justice;Learning;learning ability;longitudinal design;Low income;meetings;Mental Depression;Mental disorders;Mental Health;Methods;novel;Outcome;Pain;Parents;Participant;Pathogenicity;peer;perceived discrimination;physical abuse;Play;Poetry;Population;Prevalence;prevent;Prevention;Prevention program;Prevention strategy;Primary Prevention;Prisons;Problem behavior;Process;process evaluation;programs;promote resilience;protective factors;psychosocial;public health priorities;Quasi-experiment;randomized effectiveness trial;Reporting;research study;resilience;response;Risk;Risk Behaviors;Role;school health;Schools;Scientific Advances and Accomplishments;Self Management;Siblings;social;social emotional learning;social relationships;sociocultural determinant;socioeconomics;Standardization;stressor;student participation;Students;substance use;Suicide;supportive environment;Symptoms;System;teacher;Teacher Professional Development;Teenagers;Testing;Time;trend;urban setting;verbal;Withdrawal;Youth

PROJECT_TITLE: Supporting Student Health and Resiience


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Rural Health;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Some patients who undergo interhospital transfer who do not experience a time sensitive emergency, such as trauma or heart attack, experience worse outcomes—particularly for rural patients who experience the highest levels of mortality and are the most likely to be transferred. Identifying the factors that contribute to worse outcomes is challenging due to a lack of integrated datasets that contain all of the data necessary to conduct in-depth analyses to identify which factors contribute to poorer outcomes. Our study will create a comprehensive data management platform that will use geographic information systems and other spatial analytics to combine patient electronic health record data, medical transport data, social determinants of health data, and other location data to identify significant factors that contribute to the transfer of rural patients and their associated clinical outcomes.

PI_NAMEs: REIMER, ANDREW PAUL (contact)

PROGRAM_OFFICER_NAME: PICHARDO, CATHERINE MELISSA

PROJECT_TERMS: Academic Medical Centers;access disparities;Address;Ambulances;American;analytical tool;Area;billing data;Cardiac Catheterization Procedures;Caring;Categories;Censuses;Classification;Clinic;Clinical;clinical decision support;Communities;comorbidity;comparative;Complex;cost;Country;County;critical access hospital;Data;Data Analyses;data exploration;data integration;data management;Data Management Resources;data repository;data resource;Data Set;database design;Database Management Systems;Databases;Decision Making;digital data;Dimensions;disparity reduction;Electronic Health Record;Emergency Situation;experience;Geographic Distribution;Geographic Information Systems;Geography;Guidelines;Health;health care availability;health care service;health data;health disparity;Health Services;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Helicopter;Hospitals;Improve Access;Individual;Infrastructure;innovation;Insurance;Intervention;Investigation;Life;Location;Medical;medical specialties;Monitor;mortality;Myocardial Infarction;National Institute on Minority Health and Health Disparities;Nature;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome disparities;Patient Transfer;Patients;Policies;Population Density;Poverty;Primary Care;Production;Protocols documentation;Provider;Research;Resources;Role;Rural;rural America;rural area;rural dwellers;rural patients;Rural Population;rural setting;rurality;Services;social health determinants;social inclusion;Source;Stroke;Structure;System;Thrombectomy;Time;tool;Transportation;Trauma;underserved area;United States Agency for Healthcare Research and Quality;Update;usability;Work

PROJECT_TITLE: Using spatial analytics and social determinants of health to redefine critical access to medical transport services for rural populations

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Although it has previously been established that there is a lack of racial and ethnic diversity in the oncology physician workforce, the impact of this lack of diversity on cancer care and outcomes for patients with cancer remains unknown. This proposal is relevant to public health because we will identify whether physician team diversity may serve as a previously unidentified mechanism of improving clinical care and reducing racial and ethnic disparities in cancer outcomes.

PI_NAMEs: BOATRIGHT, DOWIN ;GROSS, CARY P. (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Affect;American Medical Association;Area;Association of American Medical Colleges;Black race;Businesses;cancer care;cancer diagnosis;cancer health disparity;cancer therapy;Caring;Characteristics;clinical care;Clinical Data;Colorectal Cancer;contextual factors;Data;Data Linkages;Data Sources;Diagnosis;Disparity;Early Diagnosis;end of life;end of life care;Equity;ethnic disparity;ethnic diversity;Ethnic Origin;General Population;geographic difference;Geographic Locations;Geography;Goals;Guidelines;Health system;Healthcare Market;Hematology;improved;indexing;Individual;individual patient;Knowledge;Latinx;Latinx population;Literature;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical specialties;Medicare;Medicine;Methods;neoplasm registry;novel;novel strategies;Oncologist;Oncology;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Patterns of Care;Performance;Physicians;Play;Population;population based;Provider;Public Health;Quality of Care;Race;racial disparity;racial diversity;Research;Retrospective Studies;Role;Science;Screening for cancer;SEER Program;sociodemographics;Stage at Diagnosis;Structural Racism;Training Programs;Variant;Work

PROJECT_TITLE: Diversity in the Cancer Care Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Pelvic Floor Disorders Network Cycle V Renewal – UT Southwestern NARRATIVE This application describes the qualifications and experience of the Female Pelvic Medicine and Reconstructive Surgery faculty and research teams at the University of Texas Southwestern Medical Center and Parkland Hospital and the facilities and patient population available to carry out clinical protocols sponsored by the Pelvic Floor Disorders Network (PFDN). With a growing, diverse clinical patient population, a committed and seasoned research team with a pedigree of successful internal and external collaborations, and the resources and expertise to champion additional translational PFD research, UT Southwestern is committed and energized to continue its partnership in the PFDN as a clinical site.

PI_NAMEs: RAHN, DAVID DWIGHT (contact)

PROGRAM_OFFICER_NAME: TEPEDE, ABISOLA KAFAYAT

PROJECT_TERMS: Address;aged;American;Basic Science;Behavioral;biobank;Biological Markers;Caring;Clinic;Clinical;clinical center;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Clinics and Hospitals;Collaborations;Colorectal Surgery;comparative effectiveness study;Core Facility;Data;Dedications;Devices;Disease;Enrollment;Epigenetic Process;epigenetic regulation;Estrogens;ethnic diversity;Etiology;evidence base;experience;Faculty;Fecal Incontinence;Female;follow-up;Functional disorder;Funding;Gastrointestinal tract structure;Gene Expression Regulation;genetic association;genetic pedigree;Genomics;Goals;Hospitals;Human;human tissue;Infrastructure;innovation;Institution;Investigation;Knowledge;Latina;Latina Population;Lead;Longterm Follow-up;Lower urinary tract;Manuscripts;Medical center;Medical Indigency;Medicine;member;Mission;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;National Health and Nutrition Examination Survey;National Institute of Diabetes and Digestive and Kidney Diseases;Operative Surgical Procedures;optimal treatments;Overactive Bladder;Participant;patient population;Patient Recruitments;Patients;Pelvic Examination;Pelvic Floor Disorders;pelvic organ prolapse;Pelvis;pharmacologic;Physical Medicine;Physical Rehabilitation;Physicians;Population;population based;Postoperative Period;Preparation;Prevention;Prevention strategy;Primary Prevention;Principal Investigator;Privatization;programs;Proteomics;Ptosis;Public Health;Publications;Qualifying;racial diversity;Radiology Specialty;Reconstructive Surgical Procedures;Recording of previous events;recruit;Recurrence;Research;Research Activity;Research Personnel;Research Proposals;Resources;Role;Science;Seasons;Secure;Sensory;Site;socioeconomics;Specimen;Stress Urinary Incontinence;study population;System;Texas;Translational Research;translational scientist;translational study;Underinsured;Uninsured;United States National Institutes of Health;Universities;Urinary Incontinence;Urology;Vagina;Woman;Women's Health;Writing

PROJECT_TITLE: Pelvic Floor Disorders Network 2021


ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: Most US service members are within the late adolescent period (18 –25 years-old), which is characterized by the immaturity of the prefrontal cortex. We propose to develop an animal model that can be used to test whether alcohol abuse during late adolescence can increase the vulnerability of US Veterans to a wide range of neurological and mental health conditions. Development and characterization of this model will put us in a position to test new mechanisms and interventions to ameliorate conditions observed in our Veterans.

PI_NAMEs: MEDINA, ALEXANDRE ESTEVES (contact)

PROJECT_TERMS: addiction;Address;Adolescence;Adolescent;Adolescent Behavior;adolescent brain development;Adult;Affect;Age;age group;Age Years;Alcohol abuse;alcohol and other drug;Alcohol consumption;alcohol exposure;alcohol measurement;alcohol testing;Alcohols;Animal Model;Animals;Behavior;Behavioral;biological adaptation to stress;Blood;Blood alcohol level measurement;Brain;Canis familiaris;Centers for Disease Control and Prevention (U.S.);Chronic;chronic alcohol ingestion;combat;combat veteran;Complex;Consumption;cost;cost comparison;Data;Dependence;Development;Dopamine;dopaminergic neuron;drinking;Drug Exposure;drug of abuse;Electrophysiology (science);Emotional;Ethanol Metabolism;Event;experimental study;Exploratory Behavior;Exposure to;Family suidae;Felis catus;Ferrets;Goals;Heavy Drinking;hippocampal pyramidal neuron;Housing;Human;Impulsivity;Intervention;Length;Light;Link;Literature;Long-Term Effects;mature animal;Measures;Mental Depression;Mental disorders;Mental Health;Modeling;Molecular;Moods;Motivation;Neurologic;Neurons;neurotransmission;nonhuman primate;novel;Opiate Addiction;Opioid;Parvalbumins;Pharmaceutical Preparations;Phase;Positioning Attribute;Post-Traumatic Stress Disorders;postnatal;Predisposition;Prefrontal Cortex;Process;RBL2 gene;Reporting;Research;Rewards;Risk Taking;Rodent;Role;service member;Social Behavior;Soldier;Stress;Structure;Study models;Substance abuse problem;Suicide;Synapses;Synaptophysin;Testing;Tetrahydrocannabinol;Therapeutic Intervention;Time;transmission process;Traumatic Brain Injury;Traumatic Brain Injury recovery;underage drinking;Veterans

PROJECT_TITLE: A novel animal model to study the association between alcohol abuse during late adolescence with common conditions observed in combat Veterans


NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: RELEVANCE (See instructions): Deterioration and loss of hearing has a major negative impact on quality of life for millions of Americans. Learning induced circuit changes interact with hearing loss at multiple levels from  learning induced changes ameliorating perception despite hearing loss through the effect of hearing loss in  children during times of substantial learning plasticity, to learning following use of devices such as cochlear  implants. Understanding how learning affects auditory representations is crucial in treating hearing loss and  ameliorating quality of life.

PI_NAMEs: DRUCKMANN, SHAUL  (contact)

PROJECT_TITLE: CRCNS: US-Israeli Research Proposal: Deciphering reorganization of multi-regional activity following category learning


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: Overall Program Narrative This Center is focused on developing better, faster, more informative research tools and computational models that aid during response to and recovery from environmental emergencies. Climate change, human economic activity, and long-standing socioeconomic disparities together increase vulnerability to disasters that may involve exposure to hazardous chemicals. We bring together a team of scientists from biomedical, geosciences, data science and engineering disciplines to propose solutions for characterization and management of both existing and environmental emergency-created hazardous waste sites in both coastal and in-land regions.

PI_NAMEs: RUSYN, IVAN  (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Academia;Acute;Address;adverse outcome;Air Pollutants;air sampling;Analytical Chemistry;anthropogenesis;Area;Attention;Basic Science;Benchmarking;Big Data;biomedical scientist;Chemical Exposure;Chemicals;Chemistry;Childhood;climate change;Communities;community engagement;community organizations;Complex;Complex Mixtures;Computer Models;cost;Coupled;Data;Data Analyses;data analysis pipeline;Data Engineering;data management;Data Science;Decision Making;Development;disaster resilience;Disasters;Discipline;Dose;Economics;Education;Emergency response;Emergency Situation;Engineering;Environmental Health;Environmental Impact;Evaluation;Event;experience;Experimental Models;Exposure to;Faculty;First Aid;first responder;Funding;Geographic Distribution;Geoscience;Goals;Government Agencies;hazard;Hazardous Chemicals;Hazardous Substances;Hazardous Waste Sites;Health;Health Hazards;Human;In Vitro;Individual;Industry;Infrastructure;inter-individual variation;interdisciplinary approach;International;Intervention;land use;Lead;Life;Methods;Modeling;Modernization;multidisciplinary;National Institute of Environmental Health Sciences;neighborhood disadvantage;next generation;Nongovernmental Organizations;North Carolina;novel;novel strategies;outreach;Pathway interactions;Population;Population Growth;Postdoctoral Fellow;Predisposition;Pregnancy;Premature Birth;Prevention;Program Description;programs;promote resilience;Public Health;Quantitative Evaluations;rapid detection;rapid technique;Readiness;Recovery;remediation;Reproducibility;Research;Resources;respiratory health;response;Risk;Risk Assessment;Sampling;Science;Scientist;Services;Site;skills;socioeconomic disparity;Soil;student training;Students;Superfund;support tools;Techniques;Technology Transfer;Testing;Texas;Time;Tissue Microarray;tool;Toxic effect;Training;Translating;Translational Research;Universities;University adminstration;volatile organic compound;Vulnerable Populations;wasting;Water;Weather;Work

PROJECT_TITLE: Comprehensive tools and models for addressing exposure to mixtures during environmental emergency-related contamination events


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

PHR: Project 1 Narrative Measurements of hazardous substances in environmental samples have traditionally focused on a small subset of target compounds largely selected from toxicology studies. However, these small targeted studies create a huge gap in our understanding of the entire potential exposures, because thousands of new chemicals are introduced into commerce each year. In this proposal, we will employ untargeted analyses combining ion mobility spectrometry (IMS) structural assessments, mass spectrometry (MS) m/z measurements and computational capabilities for the comprehensive assessment of novel chemical features detected in complex environmental samples obtained before, during and after environmental emergencies. The untargeted measurements will then be used to populate new targeted list with thousands of hazardous substances of potential interest for their rapid characterization and quantitation.

PI_NAMEs: BAKER, ERIN S (contact)

PROJECT_TERMS: Address;Algorithms;analytical method;Big Data;Characteristics;Chemical Exposure;chemical spill;Chemicals;cheminformatics;Classification;cloud based;Collaborations;Commerce;community engagement;Complex;computerized data processing;Computing Methodologies;Coupled;Data;Data Analyses;data dissemination;data management;Databases;Defect;detection method;Development;dimensional analysis;Dimensions;Disasters;Emergency Situation;environmental chemical;Environmental Engineering technology;Environmental Impact;Environmental Monitoring;Environmental Risk Factor;Environmental Science;Evaluation;Event;experience;Exposure to;feature detection;Funding;Grouping;hands-on learning;Hazardous Chemicals;Hazardous Substances;Health;Human;In Vitro;in vivo;instrument;instrumentation;interest;Investigation;ion mobility;Libraries;Liquid Chromatography;liquid chromatography mass spectrometry;Location;Machine Learning;machine learning algorithm;Mass Spectrum Analysis;Measurement;Measures;Modeling;Molecular;novel;organ on a chip;Parents;Phase;Process;Property;public database;remediation;Research;Resolution;response;Risk;Sampling;Sampling Studies;Science;screening;soil sampling;Solid;Specific qualifier value;Spectrometry;Statistical Data Interpretation;stem;Structure;Superfund;Testing;Time;tool;Toxicology;Training;Translations;trend;volatile organic compound;Water;Work;Xenobiotics

PROJECT_TITLE: Project 1


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Infectious Diseases;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The proposed research is relevant to public health because the study of gene expression and growth rate of uropathogenic E. coli during urinary tract in postmenopausal women will lead to a better understanding of how these agents of urinary tract infection cause the second most frequent infection in humans. This work is consistent with the NIH/NIAID mission, which is to conduct and support basic and applied research to better understand, treat, and ultimately prevent infectious diseases.

PI_NAMEs: ANDERSON, MARK T. (contact);PEARSON, MELANIE M.

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: 21 year old;acute infection;Age;Animal Model;Applied Research;ascending urinary tract infection;Bacteria;Bacterial Genes;Basic Science;Behavior;Bladder;Classification;Clinical;cohort;Communicable Diseases;cost;Development;Disease;disorder prevention;Elderly woman;Environment;Escherichia coli;fitness;follow-up;Funding;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;Goals;Growth;Hospitalization;Human;human old age (65+);Immune response;Infection;Infective cystitis;insight;Intervention;Intestines;Life Style;Measures;Mission;Modeling;Molecular;Monitor;mouse model;Mus;National Institute of Allergy and Infectious Disease;novel;Older Population;Outcome;pathogen;Pathogenesis;pathogenic Escherichia coli;Patients;Pattern;Population;Postmenopause;Predisposition;prevent;Prevention;programs;Proxy;Public Health;rapid growth;Recurrence;Research;response;Testing;Therapeutic;Time;time use;transcriptome;United States National Institutes of Health;Urinary tract;Urinary tract infection;Urine;Uropathogenic E. coli;Virulence;Virulence Factors;virulence gene;Woman;Women's mortality;Work;young woman

PROJECT_TITLE: E. coli virulence gene expression during clinical UTIs in women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-N(80)]