NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Contraception/Reproduction;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Women's Health Research

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE: Due to the lack of access to human embryonic and post-natal tissue, we know very little about how our gonads (testes and ovaries) develop and function. Within our proposal, we describe novel methods to develop human male and female gonad organoids “in a dish” that mimic testis and ovary developmental patterns and functions. These gonad organoids can be used for many applications including toxicology analysis, preclinical drug side- effect assessment, patient-specific diagnosis, disease modeling, and development of new reproductive and contraception technologies.

PI_NAMEs: JORDAN, PHILIP W (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;assisted reproduction;Biological Models;Bioreactors;Brain;Cell Death;cell motility;Cells;Chicken Model;Chickens;Circulation;Coculture Techniques;congenital anomaly;Contraceptive methods;CRISPR/Cas technology;Data;Development;Diagnosis;Diagnostic;diagnostic assay;Diameter;Diffusion;Disease;disease model;disease phenotype;DNA Sequence Alteration;Drug Screening;Drug Side Effects;Embryo;Embryonic Development;embryonic stem cell;Engineered Gene;Engineering;Enhancers;Environment;epigenome;Evaluation;experimental study;Female;Fertilization;fetal;Foundations;FOXL2 gene;Gametogenesis;Generations;Genes;Germ Cells;gonad development;Gonadal structure;Human;human female;human male;human model;human pluripotent stem cell;Immunodeficient Mouse;In Vitro;Incidence;Infertility;Investigation;Knowledge;male;Mammals;Maps;Meiosis;Methods;Microscopy;model organism;Modeling;Molecular;Monkeys;mouse model;Mus;mutant;Mutation;novel;Nutrient;offspring;organ growth;Organ Model;Organoids;Ovary;Oxygen;Patients;Pattern;Pluripotent Stem Cells;Positioning Attribute;postnatal;pre-clinical;Procedures;Production;Protocols documentation;Publishing;Quantitative Reverse Transcriptase PCR;Regenerative Medicine;reproductive;reproductive development;Reproductive system;Research;Resolution;sex;sex chromosome aneuploidy;sex determination;sex development disorder;Sexual Development;SF1;Slice;Somatic Cell;Specific qualifier value;Standardization;stem cell organoids;stem cells;Structure of primordial sex cell;success;System;Techniques;Technology;Testing;Testis;Tissues;tool;Toxic effect;Toxicology;transcription factor;transcriptome;transcriptomics;Turner's Syndrome;Western Blotting;WT1 gene;Xenograft procedure

PROJECT_TITLE: Pluripotent stem cell-derived organoid model of human gonad development, functions, and disorders


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE: In this proposal, we will assess the therapeutic efficacy of human MSC expressing bi- functional therapeutics and safety kill switch in humanized breast to brain metastatic tumor models. The developed agents and strategies will be designed to be clinically translatable and should have a major impact in translating cell based therapies for metastatic breast to brain tumors.

PI_NAMEs: SHAH, KHALID A (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Adult;advanced breast cancer;Agonist;Allogenic;anti-PD-1;anti-PD-L1 antibodies;anti-PD1 antibodies;Apoptosis;Arteries;Belgium;Biological Assay;Boston;Brain;Brain Neoplasms;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Cancer Patient;carcinogenicity;Caspase;CD8-Positive T-Lymphocytes;Cell Death;cell killing;Cell Therapy;Cells;cellular engineering;Clinic;Clinical;Clinical Research;clinical translation;clinically relevant;Collaborations;Communication;Cytotoxic agent;Cytotoxic Chemotherapy;Data;Dendritic Cells;design;efficacy evaluation;Engineering;Ensure;Epidermal Growth Factor Receptor;Estrogen Receptors;Flow Cytometry;FOXP3 gene;genotoxicity;Goals;Home;home test;Human;Human Engineering;humanized mouse;IL2RA gene;imaging agent;Immune;immune cell infiltrate;immune checkpoint blockade;immune modulating agents;Immune response;Immunohistochemistry;immunoregulation;Immunotherapy;improved;Incidence;Induction of Apoptosis;Inhibition of Cell Proliferation;Injections;Intracarotid;Intracranial Neoplasms;Laboratories;Lead;Leptomeningeal Neoplasms;Leptomeninges;Ligands;Mammary Neoplasms;Mediating;Mesenchymal Stem Cells;Metastatic breast cancer;Metastatic malignant neoplasm to brain;Modality;Modeling;Molecular;mouse model;Mus;Myeloid-derived suppressor cells;nanobodies;Neoplasm Metastasis;neoplastic cell;next generation;Non-Small-Cell Lung Carcinoma;novel;Paclitaxel;Pathway interactions;Patients;Pattern;Phase;Phase I Clinical Trials;Phase I/II Trial;Positron-Emission Tomography;preclinical study;Predisposition;Primary Brain Neoplasms;Progesterone Receptors;programmed cell death protein 1;Proteins;Publishing;receptor;Recombinants;recruit;Regulatory T-Lymphocyte;Reporter;Resistance;response;Safety;safety assessment;Science;Signal Pathway;Simplexvirus;systemic toxicity;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Thymidine Kinase;TNFRSF10A gene;TNFSF10 gene;Toxic effect;transcriptome sequencing;Translating;Translations;Treatment Efficacy;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor growth;tumor microenvironment

PROJECT_TITLE: Targeting metastatic tumors with engineered cellular therapies

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Multi-omics integration analysis is needed to better understand the underlying biological mechanisms, and hetero- geneity in complex diseases. We will develop and apply integrative and nonlinear Bayesian methods that leverage the rich information in data from multiple omics types to identify biological predictive pathways, important driver biomarkers and clinically molecular disease subtypes. The application of our methods to diverse complex disease datasets will likely provide new data that enable assessment of diagnosis and personalized treatment strategies.

PI_NAMEs: CHEKOUO TEKOUGANG, THIERRY  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Bayesian Method;Biological;Biological Markers;Cardiovascular Diseases;Charge;Clinical;Complex;Data;data integration;Data Set;database of Genotypes and Phenotypes;Diagnosis;Disease;disorder subtype;epigenomics;Genomics;Genotype;Heterogeneity;improved;Joints;learning strategy;Malignant Neoplasms;Medicine;Methods;Modeling;Molecular;Molecular Disease;Multiomic Data;multiple omics;Neurodegenerative Disorders;novel;Pathway interactions;personalized medicine;predict clinical outcome;predictive marker;Production;Prognostic Marker;Proteomics;statistical learning;Technology;The Cancer Genome Atlas;Time;Tissues;transcriptomics;treatment strategy;user friendly software

PROJECT_TITLE: Interpretable Bayesian Non-linear statistical learning models for multi-omics data integration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: HUNTER COLLEGE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Overall The underserved vulnerable African American, Asian-Pacific American and Hispanic American populations in the PA-NJ-NYC region experience significant cancer-related health disparities across the cancer continuum, from a higher prevalence of cancer risk factors to delayed screening and diagnoses, experiencing more advanced disease, and poorer outcomes. SPEECH has made significant strides toward transforming cancer health disparities research and education; research infrastructure and platforms that enabled investigators to advance cancer health equity in these underrepresented and underserved populations. In the next five years, our Partnership aims to advance cancer health disparities research, training/workforce development, and community-informed interventions by breaking structural, systemic barriers and promoting inclusive excellence across disciplines among basic, clinical and population science researchers, trainees and diverse underserved communities

PI_NAMEs: ERBLICH, JOEL  (contact);FORD, JENNIFER S;MA, GRACE X.;RAGIN, CAMILLE C.

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Address;advanced disease;Advanced Malignant Neoplasm;African American;anti-cancer research;Area;Asian Americans;Asian Pacific American;aspirate;Basic Science;bench to bedside;Bioinformatics;Biometry;Black race;cancer education;cancer health disparity;Cancer health equity;Cancer Intervention;cancer prevention;cancer risk;career development;Career Mobility;Clinical Sciences;Collaborations;college;Communities;community based participatory research;community engaged approach;community engaged intervention;community engagement;Community Health Aides;community organizations;Community Outreach;Competence;Comprehensive Cancer Center;County;COVID-19 pandemic;Data;Death Rate;Diagnosis;Discipline;Doctor of Philosophy;Education;education research;Equity;ethnic minority;Evaluation;evidence base;experience;Faculty;Feedback;Fostering;Foundations;Fox Chase Cancer Center;Funding;Grant;Health;Health Disparities Research;Health equity research;High Prevalence;Hispanic Americans;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Malignant Neoplasms;member;Mentors;Mentorship;Methods;Minority;Modeling;Monitor;mortality;multidisciplinary;Needs Assessment;Neighborhoods;next generation;Outcome;outreach;outreach program;Pilot Projects;Population;Population Sciences;Positioning Attribute;Poverty;programs;Publications;racial minority;Recommendation;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Schools;Science;Scientist;screening;skills;social determinants;Societies;Strategic Planning;structural determinants;Students;success;systemic barrier;Target Populations;Training;translational approach;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Vision;Workforce Development

PROJECT_TITLE: (2/2) TUFCCC/HC Regional Comprehensive Cancer Health Disparities Partnership


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ERBLICH, JOEL  (contact)

PROJECT_TERMS: Accountability;Address;Advanced Malignant Neoplasm;Advisory Committees;African;African American;American;anti-cancer research;Asian;Asian Pacific American;Black race;cancer health disparity;cancer prevention;Cancer Research Project;career;Collaborations;college;Communication;Communities;community advisory board;community organizations;Community Outreach;Decision Making;design;Doctor of Philosophy;Education;Education and Outreach;Ensure;Equity;equity, diversity, and inclusion;ethnic minority population;Evaluation;experience;Faculty;Fostering;Foundations;Fox Chase Cancer Center;Goals;Grant;Health Disparities Research;Health Sciences;Health system;Hispanic Americans;implementation outcomes;improved;Infrastructure;Institution;inter-institutional;Joints;Latinx;Leadership;Letters;Localized Malignant Neoplasm;medical schools;meetings;member;Mentors;Mission;multidisciplinary;New Jersey;New York City;operation;Organization administrative structures;organizational structure;Outcome Measure;Performance;Philadelphia;population health;Productivity;programs;racial minority population;Regional Cancer;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Science;Services;Structure;systemic barrier;Underserved Population;Universities;Vision;Work

PROJECT_TITLE: TUFCCC/HC Regional Comprehensive Cancer Health Disparities Partnership


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Primary muscle tension dysphonia (pMTD) is a functional voice disorder that impacts communication, occupation, and quality of life. Although muscle tension and hyperfunction in the laryngeal system is the prevalent theory underlying patient symptoms of vocal effort, fatigue, and discomfort, previous studies comparing well-vetted physiological laryngeal muscle metrics and self-reported symptoms from our lab suggests pMTD may have more to do with an altered sensory system than aberrant motor patterns. The goal of this proposal is to elucidate the role of sensory mechanisms in pMTD and their relationship to pMTD symptomology.

PI_NAMEs: SHEMBEL, ADRIANNA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Absenteeism;Acoustics;Address;Awareness;Biological Assay;bodily sensation;central sensitization;Clinical;Communication;comparison control;Control Groups;cost;Diagnostic;diagnostic strategy;Dysphonia;elastography;Emotional;Equipment and supply inventories;Esthesia;Exclusion;experience;Fatigue;Functional disorder;Goals;Hand;improved;Investigation;Laryngeal muscle structure;Laryngoscopy;Larynx;Leg;Literature;Location;Measures;mechanical pressure;mechanical stimulus;Motion;Motor;Motor output;Muscle;Muscle Tension;Musculoskeletal;National Institute on Deafness and Other Communication Disorders;Neurologic;Neurologic Voice Disorder;Nociception;Occupational;Occupations;Optics;Outcome;Output;Patient Self-Report;Patients;Pattern;Persons;Physiological;Play;Productivity;Protocols documentation;Quality of life;Recording of previous events;Reporting;response;Role;Sensory;sensory mechanism;sensory system;Severities;Signs and Symptoms;social;Somatoform Disorders;somatosensory;stem;Stimulus;Symptoms;Syndrome;System;Tactile;tactile stimulation;Technology;Test Result;Testing;theories;United States;vocal cord;Voice;Voice Disorders;Work

PROJECT_TITLE: Sensory Mechanisms in Primary Muscle Tension Dysphonia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-H(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KRAMPIS, KONSTANTINOS  (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;African;Algorithms;American;Applications Grants;Artificial Intelligence;artificial intelligence algorithm;Asian;Bioinformatics;biological systems;Biometry;Biostatistics Core;Cancer Biology;cancer genetics;cancer health disparity;cancer prevention;career;Cell division;ChIP-seq;Clinical;clinical application;Clinical Informatics;Clinical Trials;Collaborations;Collection;Communities;computer infrastructure;Consultations;cost effective;Data;Data Analyses;Data Protection;data resource;Data Set;Database Management Systems;Development;Diverse Workforce;DNA sequencing;Doctor of Philosophy;Education;Environment;Epigenetic Process;epigenomics;Equity;ethnic minority population;experience;Experimental Designs;Fostering;Funding;Future;Genetic;Genomics;Goals;Grant;graph neural network;Health Disparities Research;High Performance Computing;Informatics;Infrastructure;innovation;Institution;instrument;interest;Investigation;Knowledge Extraction;Laboratories;Latinx;Leadership;Link;Machine Learning;Malignant Neoplasms;Manuscripts;Medical Genetics;member;Methods;minority investigator;minority trainee;Mission;Molecular;Multiomic Data;New Jersey;New York City;novel;Phase;Philadelphia;Pilot Projects;Play;Population Sciences;preclinical study;Productivity;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Qualitative Research;racial minority population;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Resource Sharing;Retrieval;Ribosomal RNA;Role;Science;Secure;Services;single-cell RNA sequencing;skills;software development;statistics;Students;Surface;System;systemic barrier;Technology;tool;Training;transcriptome sequencing;Underrepresented Minority;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Core (BBC)


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Health Services;Liver Cancer;Liver Disease;Precision Medicine;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: NARRATIVE We propose to leverage our successful network and proven operational expertise to develop an optimized, evidence-based approach to early HCC detection in patients with indeterminate liver nodules (ILNs) – a commonly encountered, high-risk group in need of accurate risk stratification and surveillance strategies. Our Translation Research Cancer will leverage our Clinical Validation Center for HCC to efficiently recruit patients with ILNs to (1) validate the effectiveness of our novel biomarker-based risk stratification model, (2) evaluate the effectiveness of surveillance abbreviated MRI and contrast enhanced ultrasound for detecting early-stage HCC, and (3) compare the cost effectiveness, using micro-simulation modeling, of surveillance strategies including a precision screening model for patients with ILNs. Overall, our proposal will transform our approach to early HCC detection in patients with ILNs by validating evidence-based and cost-effective strategies to optimize HCC risk stratification and HCC surveillance.

PI_NAMEs: HOSHIDA, YUJIN ;SINGAL, AMIT  (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Abbreviations;Abdomen;Absenteeism at work;Address;American;Anxiety;Benign;Biological Markers;biomarker panel;biomarker validation;Biopsy;Blood;blood-based biomarker;Cancer Etiology;Center for Translational Science Activities;Cessation of life;Cirrhosis;Classification;Clinical;clinical practice;cohort;Cohort Studies;comparative cost effectiveness;Complement;contrast enhanced;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Detection;Diagnosis;Diagnostic;Early Detection Research Network;Early Diagnosis;effectiveness evaluation;effectiveness validation;Evaluation;evidence base;experience;Facilities and Administrative Costs;Funding;Goals;Harm Reduction;high risk;high risk population;Image;imaging biomarker;improved;individual patient;Infrastructure;Lead;Literature;Liver;liver cancer model;Liver diseases;Magnetic Resonance Imaging;Malignant neoplasm of liver;Meta-Analysis;Methodology;Modeling;models and simulation;National Cancer Institute;NCI Center for Cancer Research;Nodule;novel;novel marker;Outcome;patient oriented;Patient Recruitments;Patients;performance tests;personalized care;personalized screening;Phase;precision medicine;Primary carcinoma of the liver cells;programs;psychologic;Radiation exposure;Recommendation;recruit;Risk;risk stratification;screening;Series;Serum;Site;Specific qualifier value;Standardization;Study models;surveillance strategy;System;Testing;translational cancer research;tumor;ultrasound;Validation;Variant;Work;α-Fetoproteins

PROJECT_TITLE: Precision Risk Stratification and Screening for HCC among Patients with Indeterminate Liver Nodules


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: REVENSON, TRACEY A (contact)

PROJECT_TERMS: 3-Dimensional;Acculturation;Address;Affect;African American;American Society of Clinical Oncology;arm;Bass;Biostatistics Core;Black race;Cancer Center;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;Cervical;Communication;Communities;Community Outreach;Comparison arm;Conflict (Psychology);Country;cultural values;Data;Decision Aid;Decision Making;Devices;Dimensions;Doctor of Philosophy;education research;Educational Materials;Effectiveness;efficacy evaluation;efficacy testing;eHealth;ethnic diversity;Family;Funding;Gallbladder;Gender;Genes;Genetic;Genetic Counseling;genetic information;Genetic Risk;Genetic study;genetic testing;genomic profiling;Genomics;Germ Lines;Goals;Grant;Health;Health behavior change;health equity;Health Promotion;hereditary risk;High-Risk Cancer;Hispanic Americans;improved;Information Management;innovation;Intervention;intervention participants;Knowledge;Language;Latinx;Latinx population;Link;Liver;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Marketing;Medical;Medical Genetics;Methods;Modeling;mortality;Mutation;New York City;Not Hispanic or Latino;Oncologist;Oncology;Patient Preferences;Patient Recruitments;Patients;Perception;Philadelphia;Policies;Population;Population Heterogeneity;precision oncology;preference;primary outcome;Provider;provider communication;Public Health;racial diversity;randomized trial;Readiness;recruit;Reporting;Research Personnel;Research Project Grants;Risk;Risk Assessment;secondary outcome;Site;Spanish;Stomach;support tools;systemic barrier;Tablets;Test Result;Testing;tool;treatment arm;tumor;Underserved Population;vector;Vision;Work;Writing

PROJECT_TITLE: Full Research Project 1: Testing the Efficacy of an eHealth Decision Support Tool to Help Latinx Cancer Patients Make Informed Decisions About Tumor Genomic Testing


ORG_DEPT: PATHOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Lineage plasticity is a developmental process of cell reprogramming employed by cancer cells as a mechanism of therapy resistance. Dr. Linares’s application for the R50 Research Specialist Award will support Dr. Diaz-Meco’s research program focused on elucidating the molecular mechanisms that regulate lineage plasticity in prostate tumors. Unveiling the mechanisms that control this process is crucial to find new targets for castration-resistant prostate cancer.

PI_NAMEs: LINARES RODRIGUEZ, JUAN FRANCISCO  (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: androgen independent prostate cancer;Area;Automobile Driving;Award;Bioinformatics;bioinformatics tool;Cancer Biology;cancer cell;cancer cell differentiation;Cell Reprogramming;Dedications;design;Developmental Process;effective therapy;Epigenetic Process;Funding;Grant;human disease;in vivo;Inflammation;Knowledge;Laboratories;Malignant neoplasm of prostate;Malignant Neoplasms;Medicine;Mesenchymal;Metabolism;Molecular;Molecular Biology;mouse model;Neurosecretory Systems;novel;Pathology;pressure;Process;programs;prostate cancer cell;Prostatic Neoplasms;Research;Resistance;Scientist;Seminal;Signal Transduction;Solid;Specialist;success;Technical Expertise;Therapeutic;Time;Training;tumor metabolism;Variant;Wages

PROJECT_TITLE: Molecular mechanisms driving therapy-induced lineage plasticity


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE A major challenge in thwarting the alarming increase in methamphetamine use, especially in men who have sex with other men (MSM), is the high relapse rate, which is often precipitated due to the enhanced emotional reactivity to drug-related cues, a comprehensive examination of which is non-existent in MSM with methamphetamine use disorder. This study aims to objectively quantify reactivity to methamphetamine cues in MSM and test the effectiveness of cognitive reappraisal, a neuroscientifically well-characterized self-regulation technique, in decreasing such reactivity and evaluate its clinical outcomes. Successful completion of this project will advance mechanistic research into the psychophysiological assessment of reactivity to methamphetamine cues in an understudied population, which will aid in the development of evidence-based interventions for relapse prevention in methamphetamine use disorders.

PI_NAMEs: PARVAZ, MUHAMMAD ADEEL (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Abstinence;addiction;adverse outcome;Arousal;Attenuated;Behavior Therapy;Behavioral;Clinical;cocaine cue;Cocaine use disorder;cognitive control;cognitive reappraisal;cohort;comparison control;Control Groups;craving;cue reactivity;Cues;design;Development;drug seeking behavior;Drug usage;effectiveness testing;Electroencephalography;Emotional;Evidence based intervention;executive function;experience;FDA approved;follow-up;Foundations;HIV;improved;Incubated;Individual;Informal Social Control;Intervention;Knowledge;Light;Measures;Mediating;men who have sex with men;Methamphetamine;Methamphetamine overdose;methamphetamine use;Methamphetamine use disorder;methamphetamine user;neurophysiology;opioid epidemic;Outcome;Outcome Measure;overdose death;Participant;Patient Self-Report;Patients;Pharmaceutical Preparations;Phase;Population;Prefrontal Cortex;Prevalence;Psychophysiology;Randomized;Regulation;Relapse;relapse prediction;relapse prevention;remediation;Research;Role;Sampling;secondary outcome;Severities;Severity of illness;sexual minority;substance use;Substance Use Disorder;success;Techniques;Testing;Time;Training;treatment adherence;Treatment outcome;treatment response;Visit;Work

PROJECT_TITLE: Cue Reactivity Modulation in MSM with Methamphetamine Use Disorder

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KLEIMAN, FRIDA E (contact)

PROJECT_TERMS: Address;adenoma;Affect;African;African American;African American population;African ancestry;biobank;Biological;Biological Markers;biomarker identification;Black race;Blood specimen;Cancer Detection;Cancer Etiology;cancer health disparity;cancer risk;caucasian American;Caucasians;Cessation of life;Characteristics;college;Colon;colon cancer patients;Colon Carcinoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Community Outreach;Consent;Data;Death Rate;Development;Diet;disparity elimination;disparity reduction;DNA Markers;DNA Methylation;Doctor of Philosophy;early detection biomarkers;Early identification;Endoscopy;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;Exhibits;experience;Fecal occult blood;Frequencies;Gene Expression;Genes;Genetic;genetic variant;high risk;high risk population;improved outcome;in vitro Model;Incidence;Individual;Intervention;Malignant Neoplasms;Measures;men;Methylation;methylation pattern;Modeling;Molecular;mortality risk;Mucous Membrane;Neighborhoods;Organoids;Outcome;patient population;patient subsets;Patients;peripheral blood;Phenotype;Pilot Projects;Polyps;Population;Positioning Attribute;pre-clinical;predictive marker;Prevalence;Prevention;Preventive treatment;Procedures;Quantitative Trait Loci;Questionnaires;racial disparity;randomized trial;Recording of previous events;Research Project Grants;research study;Risk;Saliva;saliva sample;Scientist;screening;Screening for cancer;Screening procedure;social determinants;socioeconomics;Subgroup;systemic barrier;Testing;Time;tool;tumorigenesis;United States;University Hospitals;uptake;Variant;Woman

PROJECT_TITLE: Full Research Project 2: Changes in DNA methylation phenotype in CRC


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE To address the challenge of how to effectively target neomorphic driver aberrations, where the functional consequences of the gene on tumor cell-intrinsic or tumor microenvironment processes are altered through changes in regulatory processes, binding partners, or cellular location, we propose a CTD2 Center that will employ characterize,  state-of-the-art, high-throughput computational and experimental approaches to identify,  validate, and target novel neomorphic drivers. Focusing on glioma, sarcoma, and endometrial cancers that represent high unmet need where we have identified multiple candidate neomorphic drivers, our application pathways few markers, specific immune  will address three key areas listed in PAR-21-274: (i) improve understanding of gene functions in and cellular wiring important in cancer initiation, progression, and metastasis within the context of a  human tumors; ( ii) identify and confirm biological candidate targets, and possibly associated predictive involved in ancer etiolog y which are amenable to modulation; and (iii) determine how these context-  neomorphic pathways can be harnessed in combination with established strategies that target the  system, and identify mechanisms of resistance. Our collaborative, interdisciplinary team, comprising c Drs. Mills (tumor biology/clinical trials), Deneen (molecular genetics/electroporation tumor models), Liang (computational biology), and Chen (innovative algorithms) will address this challenge through three Specific Aims: (i) to develop computational algorithms for predicting neomorphic driver aberrations; (ii) to identify and elucidate mechanisms underlying potential neomorphic driver aberrations; and (iii) to elucidate therapeutic liabilities engendered by neomorphic driver aberrations.

PI_NAMEs: DENEEN, BENJAMIN ;LIANG, HAN ;MILLS, GORDON B. (contact)

PROGRAM_OFFICER_NAME: MCCARTHY, CLAIRE ELLEN

PROJECT_TERMS: Address;Affect;Algorithm Design;Algorithms;Alleles;Area;Bar Codes;Binding;Biological;Biological Markers;Brain;Cancer Etiology;cancer initiation;cancer type;Cell Line;Cells;Clinical Trials;Code;Communities;Complement;Computational algorithm;Computational Biology;Connective Tissue;CRISPR/Cas technology;Data;Data Set;Development;DNA;DNA Binding;driver mutation;drug sensitivity;Electroporation;Endometrial Carcinoma;Ensure;Event;Failure;Funding;fusion gene;gene cloning;gene function;Gene Fusion;Genes;Genetic;genomic aberrations;Glioma;Goals;Grant;Heterogeneity;Human;Immune;Immune system;Immune Targeting;improved;innovation;Isogenic transplantation;Location;loss of function;Malignant Neoplasms;Mesoderm;Modeling;Molecular;Molecular Genetics;Mutation;Neoplasm Metastasis;neoplastic cell;novel;Outcome;Pathway interactions;patient derived xenograft model;patient screening;Patient-Focused Outcomes;Patients;personalized cancer therapy;Point Mutation;Population;Population Dynamics;Post-Translational Protein Processing;prediction algorithm;predictive marker;Process;Productivity;protein protein interaction;Proteins;Proteomics;resistance mechanism;response;RNA Interference;Sampling;Sarcoma;screening;screening program;Series;Somatic Mutation;Spatial Distribution;success;System;Systems Biology;targeted agent;targeted treatment;Testing;Therapeutic;therapy resistant;three dimensional structure;Tissues;transcriptome;transcriptome sequencing;Translating;transplant model;tumor;Tumor Biology;tumor microenvironment;tumor-immune system interactions;Validation;vector

PROJECT_TITLE: Systematic Characterization and Targeting of Neomorphic Drivers in Cancer


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: BARGONETTI, JILL E. (contact)

PROJECT_TERMS: Address;Affect;African American;African American population;African ancestry;aggressive breast cancer;American;animal imaging;Animals;Basic Research Breast Cancer;Bioinformatics;Biological;Biological Markers;biological research;Biological Specimen Banks;Biology;Biometry;Black American;Black race;BRCA mutations;BRCA1 gene;Breast Cancer Cell;Breast Cancer Patient;Cancer Biology;cancer biomarkers;cancer health disparity;Cancer health equity;cancer subtypes;Cell Culture Techniques;Cell Line;Cells;Chromosomes;Clinical;cohort;Collaborations;college;Communities;community engagement;Community Outreach;Complex;data acquisition;Data Analyses;Detection;Diagnosis;Disparity;DNA biosynthesis;DNA Damage;DNA Repair Pathway;Doctor of Philosophy;education research;Educational workshop;Eligibility Determination;empowerment;Ethics;Ethnic Origin;European;Exposure to;follower of religion Jewish;Fox Chase Cancer Center;Gene Amplification;Genetic Engineering;Genetic Screening;Goals;health disparity;Health Fairs;Human;Imaging technology;Immunohistochemistry;improved;Informed Consent;inhibitor therapy;insight;Institution;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;MDM2 gene;Mentors;Microarray Analysis;minority engagement;minority trainee;Molecular Biology;Morbidity - disease rate;mortality;mouse model;mutant;Mutation;mutation carrier;Neoplasm Circulating Cells;next generation;novel;Outcome;Participant;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pilot Projects;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Population;Probability;Proliferating;protein expression;Proteins;Race;replication stress;Research;Research Personnel;Research Project Grants;Resources;reverse genetics;Risk;Role;Sampling;Scientist;screening;Signal Transduction;Specimen;Stains;Students;systemic barrier;targeted treatment;temozolomide;Testing;therapeutic target;Tissue Microarray;Tissues;TP53 gene;Training;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Underrepresented Minority;Underrepresented Students;Universities;university student;Woman;Work;Xenograft procedure

PROJECT_TITLE: Pilot Research Project: Evaluating Black and African American Breast Cancer Populations for Therapeutic Targeting of Aberrant p53, MDM2, MDMX, and PARP signaling


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: DODD, SARAH JANE  (contact)

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;Area;Benchmarking;cancer care;cancer health disparity;Cancer health equity;Clinical;Collaborations;college;Communication;Communities;community based research;community engagement;Community Outreach;Consensus;Consensus Development;cost;Data;Data Collection;design;Development;Doctor of Philosophy;Education and Outreach;Ensure;Equity;Evaluation;experience;Feedback;formative assessment;Foundations;Fox Chase Cancer Center;functional independence;Funding;Goals;Grant;Grant Review;Health Disparities Research;health equity;Health Policy;Health system;Impact evaluation;improved;Individual;Information Dissemination;Infrastructure;innovation;Institution;Leadership;Logic;Measures;member;Mentors;Mentorship;Methods;Minority Groups;Modeling;Monitor;Online Systems;Outcome;Peer Review;Phase;Play;Policies;population health;Positioning Attribute;preservation;Procedures;Process;Productivity;programs;Publications;Recommendation;Reporting;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;senior faculty;sharing platform;social;success;System;systemic barrier;Technology;Training;underserved minority;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Planning and Evaluation Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Esophageal Cancer;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Stomach Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative We propose to enhance the effectiveness of adoptive cellular therapy in three ways: 1) increasing the memory properties of T cells, 2) engineering T cells to resist TGF-β , a T cell suppressive factor found in many cancers, and 3) identifying T cell targets for solid tumors. We will plan to treat patients with stomach and esophageal cancers whose tumors have high levels of TGF-β in a clinical trial using T cells that target a novel antigen found among stomach and esophageal cancers. We believe that this approach, if successful, can be applied to T cells targeting other solid tumors so that we may treat greater numbers of patients who have an unmet need in advanced stages of their disease.

PI_NAMEs: MORELLI, MARIA PIA;RAI, KUNAL ;YEE, CASSIAN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Advanced Malignant Neoplasm;Affinity;Algorithms;Alleles;antigen-specific T cells;Antigens;arm;ATAC-seq;Blood Cells;Blood specimen;cancer/testis antigen;CD8-Positive T-Lymphocytes;Cell Cycle Proteins;Cell Therapy;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;CTAG1 gene;cytokine;cytotoxicity;Disease;DNA Repair Gene;Dominant-Negative Mutation;Dose;Effectiveness;Effector Cell;Endowment;engineered T cells;Engineering;epigenetic memory;Epigenetic Process;epigenetic profiling;epigenomics;Epitope spreading;Epitopes;Esophagus;exhaustion;EZH2 gene;Family;first-in-human;flexibility;Functional disorder;gastroesophageal cancer;Gene Expression Profiling;Generations;Genes;gp100 Antigen;HLA-A11;HLA-A2 Antigen;immune resistance;immunogenic;immunogenicity;Immunologic Suppressor Factors;Immunology;Immunosuppression;in silico;In Vitro;in vivo;Infusion procedures;inhibitor;interleukin-21;Lung;Malignant neoplasm of esophagus;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;manufacture;Mediating;melanocyte;Memory;Modality;mortality;novel;Outcome;Ovarian;Patients;Peptides;peripheral blood;pharmacologic;Phase;Phase Ib Clinical Trial;Phenotype;Population;preferentially expressed antigen in melanoma;Prevalence;Production;programs;Proliferating;Property;Proteins;protocol development;Protocols documentation;rational design;Regulatory T-Lymphocyte;Resistance;response;retroviral transduction;Safety;Sampling;self-renewal;single-cell RNA sequencing;Solid Neoplasm;Source;Specificity;Stomach;success;Surface;T cell differentiation;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Testis;TGFBR2 gene;Tissues;Toxic effect;transcriptomics;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;tumor;Tumor Antigens;tumor microenvironment;Tumor Suppression

PROJECT_TITLE: HORMAD-specific TGF-beta resistant memory T cells for treatment of patients with Gastro-esophageal Cancer


ADMINISTERING_IC: HD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Activity;Rehabilitation

ORG_CITY: HOLLISTON

ORG_NAME: LIBERATING TECHNOLOGIES, INC.

PHR: NARRATIVE The goal of this project is to develop a highly advanced, commercially viable, bimodal walking-running prosthetic foot that is optimized in two modes (a walking mode and a running mode) and can be reimbursed under the existing L-code reimbursement structure. This novel device would provide individuals with lower limb loss who don’t currently have access to running feet due to the lack of insurance coverage, the opportunity to participate in running, sports, and other social activities with a foot optimized for high-impact activities and the practicality of not having to switch sockets. Since it is optimized for walking and running, the unique design of the Caesar foot provides a substantial increase in functional benefit over the currently available hybrid feet, which although allow for walking and running do so by compromising the foot characteristics for each.

PI_NAMEs: JOHANSSON, JENNIFER LYNNE (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Achievement;Address;Amputees;Biomechanics;Characteristics;Clinic;Code;cost;Data;design;Development;Devices;Ensure;Evaluation;Exercise;Failure;feasibility testing;Feedback;Focus Groups;foot;General Population;Goals;Government;Health;Health Benefit;Heel;Height;Home;Hybrids;improved;Individual;Industry;innovation;Insurance;Insurance Coverage;Jogging;Laboratories;Learning;limb amputation;limb loss;Limb Prosthesis;Limb structure;Lower Extremity;Manufactured basketball;Marketing;Measures;Mental Health;Modality;novel;Outcome;Patient Self-Report;Persons;Phase;Physical activity;physical conditioning;Physical Fitness;Pilot Projects;Preparation;prevent;primary outcome;Prosthesis;Prosthesis Design;prosthetic foot;prototype;psychologic;Respondent;Running;social;social engagement;Specific qualifier value;Sports;Structure;Surveys;System;Technology;Testing;Toes;Validation;verification and validation;Walking;Weight

PROJECT_TITLE: The Development of a Bimodal Walking-Running Prosthetic Foot


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Loud or extended noise can permanently damage the connections between hair cells—the sensory receptors of hearing—and auditory nerves. The goal of this proposal is to understand how damaged connections between hair cells and auditory nerves are repaired following noise. The results of these studies will identify strategies to stimulate repair in noise exposed ears to prevent subsequent nerve degeneration and hearing loss.

PI_NAMEs: SHEETS, LAVINIA  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Address;Afferent Neurons;Aging;AMPA Receptors;Automobile Driving;Biological Assay;Biological Models;Calcium;Cell Physiology;cholinergic;Cochlea;Data;defined contribution;Development;Ear;excitotoxicity;Exocytosis;Exposure to;Fishes;Functional Imaging;Funding;gain of function;genetic manipulation;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Hair Cells;Hearing;hearing impairment;Hour;Human;Image;Immunofluorescence Immunologic;Impairment;Inflammation;Inflammatory Response;injured;Injury;Innate Immune System;Inner Hair Cells;Knock-out;lateral line;Loudness;Macrophage;Maintenance;Mammals;mechanotransduction;Membrane Potentials;Metabolic stress;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Morphology;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Nerve Degeneration;nerve repair;nerve supply;Noise;noise exposure;Organ;organ repair;Pathology;Permeability;Phagocytes;pharmacologic;Pharmacology;Play;postsynaptic;presynaptic;prevent;Recovery;Recovery of Function;recruit;reinnervation;repaired;Research;ribbon synapse;Role;Sensory Receptors;Signal Pathway;Site;Stimulus;Study models;Synapses;synaptic inhibition;Synaptic Vesicles;synaptogenesis;Testing;therapeutic target;Time;Trauma;Visualization;Work;Zebrafish

PROJECT_TITLE: Roles of the Synapse in Hair-Cell Pathology

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


PROJECT_TERMS: Address;Admission activity;anti-cancer research;Award;Basic Science;Biomedical Research;cancer education;cancer health disparity;career;career development;Career Mobility;CCL7 gene;Clinical;Clinical Sciences;cohort;Collaborations;college;Communication;Communities;community academic partnership;community collaboration;community engaged research;Community Networks;Community Outreach;community partners;community research;Complement;Comprehensive Cancer Center;Core Facility;Data;design;Development;Diverse Workforce;Doctor of Philosophy;Education Projects;education research;Educational Activities;Educational process of instructing;Enrollment;Environment;Ethnic Origin;experience;Faculty;Feedback;Fellowship;First Generation College Students;Fostering;Fox Chase Cancer Center;Funding;Goals;graduate student;Grant;Growth;Health;Health Disparities Research;health disparity;Health Promotion and Education;Inequity;innovation;Institution;inter-institutional;Interdisciplinary Study;Malignant Neoplasms;Measurable;Medical;medical schools;Mentors;Mentorship;minority communities;Minority Groups;Minority Health Research;Minority-Serving Institution;multidisciplinary;novel;Pathway interactions;Pilot Projects;Population;population based;Population Sciences;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;professional students;programs;Qualifying;racial minority;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Research Training;Rotation;Science;skills;Special Population;student mentoring;Students;systemic barrier;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved community;underserved minority;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Lung;Orphan Drug;Pulmonary Hypertension;Rare Diseases

ORG_CITY: Juno Beach

ORG_NAME: AQUALUNG THERAPEUTICS CORP.

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE - NARRATIVE Pulmonary Arterial Hypertension is a debilitating often fatal disease without a cure, a serious unmet need. The inflammatory protein, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), is a key driver of unchecked inflammation and a highly novel therapeutic target and candidate gene in PAH. Our Phase I/II goals are to validate and optimize the eNAMPT- neutralizing humanized mAb, ALT-100, as a therapeutic strategy for PAH, and to complete IND-enabling studies that will facilitate ALT-100 development in human PAH trials.

PI_NAMEs: GARCIA, JOE G. N. (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Arizona;Biological Products;Bioreactors;Biotechnology;Blood Vessels;Candidate Disease Gene;Cardiac;cell bank;Characteristics;Chronic;Clinical;Clinical Trials;Collaborations;cost;curative treatments;Cyclic GMP;Data;design;Deterioration;Development;Disease;Dose;Drug Kinetics;druggable target;Exhibits;extracellular;Failure;Gene Expression Profiling;Genetic Polymorphism;Genetic Transcription;genome wide association study;genomic data;Genomics;Goals;Growth Factor;Half-Life;Human;hypertension treatment;Hypoxia;immunogenicity;improved;In Vitro;in vivo;indexing;Inflammation;Inflammatory;Intramuscular;Ligation;Link;Lung;Lung Diseases;Magnetic Resonance Imaging;Manufacturer;Marketing;Miniature Swine;Modality;Modeling;Molecular;Monoclonal Antibodies;Monocrotaline;mortality;Movement;murine monoclonal antibody;Natural Immunity;neutralizing monoclonal antibodies;new therapeutic target;NF-kappa B;nicotinamide phosphoribosyltransferase;novel;novel strategies;Parents;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phase;phase 1 study;phase 2 study;Physicians;Plasma;pre-clinical;preclinical development;Preclinical Testing;Price;Process;Property;protein expression;Proteins;public health relevance;Publishing;pulmonary arterial hypertension;Pulmonary Hypertension;Pulmonary vessels;Rattus;Reporting;Research;Right Ventricular Dysfunction;right ventricular failure;right ventricular remodeling;Risk;Role;Route;Running;scale up;Scientist;Severities;Signal Transduction;Single Nucleotide Polymorphism;Small Business Technology Transfer Research;Sprague-Dawley Rats;stable cell line;Stimulus;Structure of parenchyma of lung;Talents;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;therapeutically effective;TLR4 gene;Toxic effect;Toxicokinetics;Toxicology;transcription factor;Universities;Vascular remodeling

PROJECT_TITLE: Preclinical Development of a Novel eNAMPT-Neutralizing mAb for Pulmonary Hypertension


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: YEH, MING-CHIN  (contact)

PROJECT_TERMS: Acculturation;Achievement;Address;African American;African American population;anti-cancer research;Asian Pacific American;Awareness;Black race;Breast Cancer Detection;Cancer Burden;cancer health disparity;cancer risk;Clinical;Collaborations;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community advisory board;community based participatory research;community engaged approach;community engagement;community organizations;Community Outreach;Community Participation;community partners;community research;Competence;COVID-19 pandemic;Diagnosis;Disparity;Doctor of Philosophy;Education;education research;Educational Curriculum;Equity;ethnic minority;ethnic minority population;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Faith-based organization;Fostering;Fright;Funding;Genetic;Genetic Enhancement;genetic testing;Genetic testing for cancer risk;Genomics;Geographic Locations;Goals;Hispanic Americans;Impact evaluation;improved;Infrastructure;Inherited;Institutionalization;Intervention;Knowledge;Language;Logic;low health literacy;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Methods;Modeling;Monitor;New York City;Outcome;outreach;Outreach Research;Population;Process;Program Evaluation;programs;Race;racial minority;racial minority population;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Risk Assessment;Scientist;screening;Screening for cancer;screening program;service providers;service utilization;social health determinants;success;systemic barrier;Test Result;Testing;testing services;tool;training opportunity;Woman;Yin

PROJECT_TITLE: Community Outreach Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunization;Immunotherapy;Pancreatic Cancer;Rare Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Irreversible electroporation (IRE) is a surgical ablation technique that is currently being used clinically to treat locally advanced pancreatic cancer. CD40 is an immune receptor that helps to stimulate anti-tumor immune responses. We hypothesize that combining IRE with local delivery of an antibody that stimulates CD40 will enhance the immune effects of IRE. We propose a phase I study to evaluate the safety and preliminary efficacy of this approach. In parallel, we will perform correlative studies to demonstrate that this combination generates specific anti-tumor immune responses.

PI_NAMEs: SCHOENBERGER, STEPHEN PHILIP;WHITE, REBEKAH  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Ablation;adaptive immune response;Adaptive Immune System;Adjuvant;Advanced Malignant Neoplasm;advanced pancreatic cancer;Aftercare;Agonist;Alligators;analysis pipeline;anti-tumor immune response;Antibodies;Antigen-Presenting Cells;antitumor effect;Attention;Bioinformatics;Biological Sciences;Biopsy;Blood specimen;burden of illness;California;cancer clinical trial;Clinical;Clinical Trials;Coculture Techniques;Correlative Study;cytokine;cytokine release syndrome;Data;design;Disease;disorder control;Distant;Dose;efficacy study;Electroporation;enzyme linked immunospot assay;experience;first-in-human;Future;Hand;Human;human study;Immune;Immune response;Immunocompetent;Immunologic Adjuvants;Immunologic Markers;Immunologic Receptors;Immunology;Immunooncology;Implant;improved;in situ vaccine;Inflammation;Inflammatory;Injections;Innate Immune System;KPC model;Laboratories;Laparotomy;Liver;Localized Disease;Malignant neoplasm of pancreas;Marketing;Measurement;Measures;Medical Oncologist;Metastatic Neoplasm to the Liver;Methods;Modeling;mouse model;multidisciplinary;Mus;neoantigens;Nonmetastatic;novel strategies;Nucleic Acids;Operative Surgical Procedures;Organoids;Pancreas;pancreatic cancer model;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Patient Recruitments;Patient Selection;patient subsets;Patients;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;Phase;phase 1 study;Plasma;Positioning Attribute;pre-clinical;preclinical study;primary endpoint;Progression-Free Survivals;Qualifying;receptor;Recommendation;recruit;Recurrence;Registries;Reporting;Research;response;Safety;Sampling;scale up;secondary endpoint;side effect;Subgroup;Surgical Oncologist;Systemic Therapy;T cell response;T-Lymphocyte;Techniques;Technology;Time;TNFRSF5 gene;Toxic effect;treatment response;tumor;tumor ablation;Tumor-Derived;ultrasound;Universities;Unresectable;Vaccine Therapy

PROJECT_TITLE: Irreversible Electroporation (IRE) Combined with CD40 Agonism as In Situ Vaccine Therapy for Pancreatic Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Human Genome;Patient Safety;Precision Medicine;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Randomized controlled trials have shown that screening reduces the incidence of and mortality from colorectal cancer (CRC), the second leading cause of cancer deaths in the United States. However, screening has resulted in a growing cohort of patients with precancerous polyps and little is known about effectively managing their post-polypectomy surveillance. Thus in this proposal, we will develop and validate a comprehensive risk prediction model using polyp characteristics, and clinical and genetic risk factors to tailor surveillance; and determine the optimal strategy for CRC surveillance given an individual’s risk.

PI_NAMEs: LEE, JEFFREY KUANG ZOU (contact)

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Address;Adoption;Advanced Development;Age;Attitude;Benefits and Risks;Cancer Detection;Cancer Etiology;Caring;Categories;Cessation of life;Characteristics;Clinical;Clinical Data;clinical risk;cohort;Collaborations;Colon;Colonoscopy;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;colorectal cancer screening;Communities;comorbidity;cost;Cost Analysis;cost effective;cost-effectiveness evaluation;Coupled;Data;Diagnosis;Early identification;Eligibility Determination;ethnic diversity;Evaluation;Excision;experience;Family;follow-up;Future;Genetic;Genetic Databases;Genetic Risk;genetic risk factor;Genetic Services;genome-wide;Genomics;Genotype;Goals;Guidelines;Health Services Research;high risk;high risk population;implementation barriers;implementation facilitators;improved;Incidence;indexing;Individual;interest;International;Knowledge;life time cost;Link;Lung;Managed Care;Methods;models and simulation;mortality;Neoplasms;novel;Outcome;Pathologic;patient oriented;Patients;Performance;personalized approach;Play;Policies;polygenic risk score;Polypectomy;Polyps;population based;pragmatic trial;Precancerous Polyp;predictive modeling;predictive tools;Productivity;Prostate;racial diversity;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Resources;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;risk variant;Role;Scheme;screening;Screening for cancer;Screening for Ovarian Cancer;screening guidelines;Sensitivity and Specificity;service providers;sex;surveillance strategy;Techniques;Technology;Testing;time interval;United States;United States Preventative Services Task Force;Unnecessary Procedures;Validation;Work

PROJECT_TITLE: Personalizing Post-Polypectomy Surveillance for Colorectal Cancer Prevention

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Digestive Diseases;Liver Disease;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: LEWES

ORG_NAME: AMINO COMPANY LLC, THE

ORG_STATE: DE

PHR: 8. Project Narrative We will perform a double-blind placebo randomized clinical trial (RCT) in male and female youths 13 to 17 years of age with biopsy-documented hepatic steatosis and clinically diagnosed NAFLD. Eight weeks of treatment with AMS2392 will be compared to placebo. The primary endpoint will be liver fat content as measured by magnetic resonance imaging (MRI) at the outset and after the eight-week intervention.

PI_NAMEs: WOLFE, ROBERT R (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 17 year old;18 year old;Adherence;Adolescent;Adolescent obesity;Adverse event;Age;Aging;Alanine Transaminase;alcohol use disorder;Amino Acids;Base Composition;Behavior Therapy;Benefits and Risks;Biopsy;Blinded;Body Composition;Body Weight decreased;Caloric Restriction;Cardiovascular Diseases;cardiovascular health;Child;Childhood;Chronic;Cirrhosis;clinical diagnosis;Clinical Trials;Consumption;Creatinine;Cross-Over Studies;density;dietary supplements;Documentation;dosage;Double-Blind Method;Dual-Energy X-Ray Absorptiometry;emerging adult;Essential Amino Acids;Exercise;exercise program;Experimental Designs;Fatty acid glycerol esters;Fatty Liver;Female;Female Adolescents;Food;Formulation;Glutathione;improved;inclusion criteria;Individual;Inflammation;insulin sensitivity;Intervention;Liver;Liver diseases;liver stiffness;Magnetic Resonance Elastography;Magnetic Resonance Imaging;male;Marketing;Measures;Medical;Medical Societies;Metabolic;New Drug Approvals;non-alcoholic;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;North America;nutrition;obesity in children;Pharmaceutical Preparations;Pharmacotherapy;Placebos;Plasma;Polycystic Ovary Syndrome;Positioning Attribute;Premature Mortality;primary endpoint;Protocols documentation;Protons;Puberty;Public Health;Publishing;randomized, clinical trials;Recommendation;Safety;secondary endpoint;sex;Subgroup;success;treatment effect;treatment guidelines;Triglycerides;very low density lipoprotein triglyceride;Vitamin E;weight loss program;Youth

PROJECT_TITLE: Amino Acids and Pediatric Hepatic Steatosis


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Services;Prevention;Women's Health Research

ORG_CITY: BURLINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE Many women undergoing breast cancer screening and diagnostic imaging are diagnosed with high-risk benign breast lesions, but there is clinical uncertainty as to how aggressively to manage these cases with surgical excision, chemoprevention, and surveillance imaging. We will develop and validate new risk models for short- and long-term breast cancer risk among women with high-risk lesions, which will inform clinical practice and national guidelines for identifying cases that require aggressive interventions while sparing others from unnecessary side effects.

PI_NAMEs: SPRAGUE, BRIAN L (contact);WEAVER, DONALD LEE

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: Address;Affect;Age;Benign;Biopsy;Breast;Breast biopsy;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast density;Breast Diseases;breast imaging;breast lesion;breast pathology;calcification;cancer diagnosis;cancer risk;Caring;Case Management;Characteristics;Chemoprevention;Clinical;Clinical Management;clinical practice;cohort;Core Biopsy;cost;Data;Databases;Decision Analysis;Descriptor;Detection;Development;Diagnosis;Diagnostic Imaging;disease diagnosis;Ensure;evidence based guidelines;Excision;Future;Geography;Goals;Guidelines;Harm Reduction;Health care facility;Health Personnel;Healthcare Systems;high risk;improved;Incidence;Infrastructure;insight;Institution;interest;Intervention;Learning;learning strategy;Lesion;Literature;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;mammography registry;Medical Records;model development;Modeling;Multicenter Studies;multidisciplinary;Needles;neoplasm registry;Non-Malignant;Noninfiltrating Intraductal Carcinoma;Normal Range;Operative Surgical Procedures;Outcome;Palpable;Pathologic;Pathology Report;Patients;Policy Maker;Population;predictive modeling;Prevention;Qualitative Methods;Radiologic Finding;Radiology Specialty;Recommendation;Records;Regional Cancer;Registries;Reporting;Reproducibility;Risk;risk prediction model;Sample Size;Sampling;side effect;Specific qualifier value;stakeholder perspectives;Statistical Models;surveillance imaging;Symptoms;Time;Uncertainty;Vacuum;Validation;Woman;women's diagnosis;Work

PROJECT_TITLE: Clinical breast cancer risk prediction models for women with a high-risk benign breast diagnosis

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: KENT

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Chronic sleep disruption causes metabolic changes including increases in polyamines that promote sleep, suggesting that these polyamines act as a homeostatic `equalizer' attempting to fulfill the drive to sleep. This project seeks to improve our understanding of how and why sleep loss and polyamines are linked, which may give long-term insight into regulating sleep need and treating sleep disorders in humans. In many ways the polyamine phenomenon I have noted also reflects changes seen in Alzheimer's disease, which has long been known to occur more often in people with sleep disorders; my study also aims to determine whether polyamine increases are the mechanism that couple sleep disorders to Alzheimer's, which has implications for both prevention and treatment in the long run.

PI_NAMEs: BEDONT, JOSEPH L (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Acetylation;Acute;Age;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Ammonia;Amyloid beta-Protein;Animals;antagonist;arginase;Avena sativa;Back;Behavior;Behavioral;Binding;Biochemical;Biological Assay;Brain;career;Cell Death;Chronic;Coupled;Data;Defect;Disease;Dose;Drosophila genus;Electroencephalography;environmental enrichment for laboratory animals;enzyme activity;Enzymes;Exhibits;experimental study;Fatigue;fly;gamma-Aminobutyric Acid;Genetic Engineering;Homeostasis;Human;human model;improved;Individual;insight;Institution;Isotope Labeling;knock-down;Knowledge;Life;Link;Mass Spectrum Analysis;Measures;Mediating;Memory;Mentors;Mentorship;Metabolic;metabolome;metabolomics;Motion;Mus;mutant;Nerve Degeneration;neural;neural circuit;Neurons;neurotoxicity;Nitric Oxide Synthase;Nitrogen;nitrogen metabolism;Ornithine;Pathologic;Pathology;Pathway interactions;Persons;pharmacologic;Phase;Phenocopy;Phenotype;Physiological;Polyamines;Population;Prevention;Production;Proteins;Protocols documentation;Putrescine;Recovery;Regulation;Research;Research Personnel;Research Project Grants;response;RNA Interference;Rodent Model;Role;Running;sensor;Shapes;skills;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Stress;Supplementation;tau Proteins;Testing;Training;Urea;urea cycle;Urea Nitrogen;Wild Type Mouse

PROJECT_TITLE: Nitrogen metabolism in sleep homeostasis and pathology

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: Aggregation of the RNA binding protein TDP-43 has been reported in Alzheimer’s disease (AD) and AD-like dementia in the oldest of the elderly named LATE. We seek to identify how TDP-43 prion-like aggregation regulates the P-body function in neurons, which could provide a mechanism of TDP-43 aggregation-induced neurotoxicity. We will also determine whether P-body components can serve as new neuropathological markers for AD-related dementia.

PI_NAMEs: SHAHMORADIAN, SARAH H (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Affect;age related changes;age related neurodegeneration;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Architecture;Autopsy;Brain;Cell membrane;Cells;Complex;Core Assembly;Cytoplasm;Cytoplasmic Granules;Dementia;Disease;Elderly;Electron Microscopy;Frontotemporal Dementia;Functional disorder;Half-Life;Hippocampus;Image;Immediate-Early Genes;Immunohistochemistry;Impairment;in vivo;induced pluripotent stem cell;innovation;light microscopy;limbic-predominant age-related TDP-43 encephalopathy;Liquid substance;Membrane;Messenger RNA;Morphology;Motor Neurons;mRNA Decay;mRNA Transcript Degradation;Mus;Mutation;Names;neuronal cell body;Neurons;neuropathology;neurotoxicity;Nonsense-Mediated Decay;Organelles;Pathologic;Pathology;Patients;Phase;Phase Transition;Physical condensation;Post-Translational Protein Processing;prion-like;Process;protein aggregation;protein complex;protein TDP-43;Proteins;Proteomics;Reporting;response;Ribonucleoproteins;RNA;RNA metabolism;RNA Processing;RNA-Binding Proteins;Sampling;Spinal Cord;Stress;Syndrome;TDP-43 aggregation;Testing;Tissues;Toxic effect;Translational Repression

PROJECT_TITLE: Determine the neurotoxicity of RNA metabolism dysfunction caused by cytoplasmic TDP-43 aggregates

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative The Gene Targeting and Transgenic Shared Resource is an integral part of the Roswell Park Comprehensive Cancer Center (Roswell Park) Cancer Center Support Grant (CCSG) program (P30CA016056, PI Johnson). As the Director of the Gene Targeting and Transgenic Shared Resource with over 25 years of relevant experience, Dr. Stablewski's efforts are solely dedicated to supporting all 4 CCSG research programs with regards to keeping abreast of current genome editing technologies for the creation of genetically modified tools (animal models and cell lines). Funding of Dr. Stablewski as NCI Core-based Research Specialist will ensure the stability of an essential resource to Roswell Park's CCSG program.

PI_NAMEs: STABLEWSKI, AIMEE B (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Animal Model;Applications Grants;Area;base;Biology;Cancer Center;Cancer Center Support Grant;cancer research center director;career;Cell Line;Cells;Collaborations;Comprehensive Cancer Center;Consult;Consultations;Dedications;Development;Developmental Therapeutics Program;Doctor of Philosophy;Ensure;experience;Funding;Gene Modified;Gene Targeting;Genetic;Genetically Modified Animals;Genome;genome editing;Grant;Infrastructure;Investments;Laboratories;Malignant Neoplasms;member;Modification;neoplasm immunotherapy;new technology;Positioning Attribute;Principal Investigator;Privatization;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Scientist;Specialist;Stress;Technology;tool;Transgenic Organisms;tumor immunology;United States National Institutes of Health;Wages

PROJECT_TITLE: Development of New Technologies at Roswell Park to Further Cancer-Based Research and Treatment Through Genome Modification


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE : We are developing implantable, miniature, packaged accelerometers designed to sense incoming sound by transducing the motion of the middle ear bones. An implantable sensor is a necessary component of totally implantable auditory prostheses (e.g., hearing aids and cochlear implants), and these assistive hearing devices hold significant promise over existing systems including providing safety-enhancing continuous use, improving usability and cosmetic appearance, and allowing for a more naturalistic sound input using external ear directional cues and gain. We seek to create devices that are on the critical path to a fully implantable auditory prosthesis system, meeting the stringent performance requirements for hearing as well as enabling less invasive surgical approaches.

PI_NAMEs: GROSH, KARL  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Accelerometer;Acoustic Stimulation;Acoustics;Adoption;Affect;Age;analog;Appearance;Auditory Prosthesis;Auditory system;battery recharging;Behavior;Bilateral Hearing Loss;bone;Cadaver;Calibration;Cochlea;Cochlear Implants;Communication;conditioning;Cosmetics;Critical Pathways;Cues;Deposition;design;Devices;Dimensions;Ear;effectiveness evaluation;Electronics;Elements;Engineering;Environmental Wind;European;Exhibits;experience;External Ear;external ear auricle;Face;Female;Film;Floor;force sensor;Goals;Hearing;Hearing Aids;hearing impairment;hearing restoration;Human;Implant;implantation;implanted sensor;improved;Individual;Inherited;integrated circuit;Intervention;Language Development;Letters;life span;Location;male;Mechanics;meetings;microphone;middle ear;middle ear fluid;Middle Ear Implant;milligram;minimally invasive;Motion;Noise;novel;Operative Surgical Procedures;Output;Patients;Performance;performance tests;Pharmacologic Substance;Population;Preparation;pressure;printed circuit board;Procedures;Process;Prosthesis;prosthesis wearer;Quality of life;Research;Research Personnel;Rotation;Safety;Sampling;seal;sensor;Sensorineural Hearing Loss;Signal Transduction;sound;Speech Perception;Sports;subcutaneous;Surgical Disarticulation;System;Temporal bone structure;Testing;Theoretical model;Thinness;Tissues;Transducers;Translations;Tympanic membrane;Unilateral Hearing Loss;United States;usability;Use Effectiveness;vibration;Weight;wireless;Work

PROJECT_TITLE: Implantable Transducer Systems for Auditory Prostheses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-A(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Obesity;Clinical Research;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: PRINCETON

ORG_NAME: VIOCARE, INC.

ORG_STATE: NJ

PHR: Current dietary assessment tools available for self-administration in children are limited and rely mostly on caregiver-report for children younger than 14 years. The proposed project will address the outstanding need for a technologically advanced dietary assessment tool specific to the U.S. pediatric population by creating the Pediatric Food Intake System (P-FITS). P-FITS will integrate Viocare’s VioScreen technology with targeted 24- hour food group screeners to improve estimation of usual dietary intakes in U.S. children ages 8-13 years.

PI_NAMEs: WEISS, RICK  (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: 9 year old;Address;Adolescence;Adolescent;Adult;Age;Assessment tool;Behavior Therapy;Belgium;Beverages;Brazil;Canada;Cardiovascular Diseases;Caregivers;Cellular Phone;Child;Child Health;Childhood;Chronic;Chronic Disease;Clinic;Clinical;cognitive function;commercialization;community setting;Computer software;Computers;Counseling;critical period;Data;Denmark;design;Development;Diet;dietary;Dietary Assessment;Dietary intake;Dietitian;Eating;electronic medical record system;elementary school;Emotional;Evaluation;expectation;experience;Feedback;Food;Food Processing;Frequencies;fruits and vegetables;Grant;Growth;Health;Health Professional;Healthy Eating;Hour;improved;indexing;innovation;Instruction;instrument;Intake;interest;Internet;Italy;junior high school;Malignant Neoplasms;Marketing;Measures;Methods;mobile application;Modification;Narration;Non-Insulin-Dependent Diabetes Mellitus;Norway;Nutrient;Nutritional status;Obesity;Online Systems;Osteoporosis;Output;Paper;Phase;Play;Population;Population Study;prototype;Puberty;Questionnaires;Recommendation;Records;Reporting;Research;Research Personnel;research study;Risk;Risk Factors;Role;Sampling;School-Age Population;Self Administration;Small Business Innovation Research Grant;Structure;System;Tablets;Technology;technology platform;Testing;Time;tool;Unhealthy Diet;United States;usability;Validity and Reliability;Visual;Well in self;Writing;Youth

PROJECT_TITLE: P-FITS: The Pediatric Food Intake Technology System


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Successful credentialing and therapeutic development of the NC GEM will provide the global scientific community with a much-needed animal model that recapitulates the human disease in all important aspects, thus greatly accelerating NC translational and basic research, ultimately towards a cure.

PI_NAMEs: FRENCH, CHRISTOPHER A (contact);KESKIN, DERIN B;SHAPIRO, GEOFFREY I

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;Address;Affect;Age;Animal Model;Basic Science;Binding;Biology;Bromodomain;Bromodomains and extra-terminal domain inhibitor;burden of illness;CD4 Positive T Lymphocytes;CD8B1 gene;CDKN2A gene;Cells;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Color;Communities;Credentialing;defined contribution;design;Disease;effective therapy;Enhancers;EP300 gene;Epigenetic Process;Ewings sarcoma;Excision;experimental study;EZH2 gene;Fusion Oncogene Proteins;Gene Activation;Gene Expression;Gene set enrichment analysis;Genetic;Genetically Engineered Mouse;Goals;Growth;histone acetyltransferase;Histones;Histopathology;Human;human disease;human imaging;Immune;immune checkpoint blockade;Immune Evasion;Immune system;Immunocompetent;Immunofluorescence Immunologic;Immunologics;immunomodulatory therapies;Immunophenotyping;Immunotherapy;improved;Knock-in;Luciferases;Maintenance;Malignant Epithelial Cell;Malignant Neoplasms;Measures;Minority;Modeling;Mus;No Evidence of Disease;novel;Nut carcinoma;Oncogenic;Operative Surgical Procedures;Outcome;Pathogenicity;Pathway interactions;Patients;Population;pre-clinical;Pre-Clinical Model;protein complex;Protein Family;Proteomics;rapid growth;recruit;relapse prevention;Repression;response;Role;small molecule;Solid Neoplasm;Squamous cell carcinoma;T-Cell Depletion;T-Cell Receptor;Tamoxifen;therapeutic development;therapeutic evaluation;therapeutic target;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;tumor;Tumor Antigens;tumor growth;tumor microenvironment;Tumor Suppressor Genes;tumor-immune system interactions;Vaccination

PROJECT_TITLE: Genetically engineered mouse model to improve therapy of NUT carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-E(55)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: There is an urgent unmet need for imaging techniques that provide improved tumor contrast enhancement in preclinical and clinical oncologic applications. We will validate the feasibility and accuracy of a novel approach, based on detecting the sub-nanosecond decay times of cancerous tissue stained with fluorescent dyes, for tumor margin assessment in patients undergoing head and neck cancer surgery.

PI_NAMEs: KUMAR, ANAND T.N. (contact)

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Aerodigestive Tract;Affect;Algorithms;antibody conjugate;attenuation;Beds;Binding;bone;Brain;cancer cell;cancer surgery;cancer type;Cancerous;Cell Culture Techniques;Classification;Clinical;clinical optical imaging;Clinical Research;contrast enhanced;Custom;Cutaneous;Detection;Development;Diagnostic;Diagnostic Neoplasm Staging;disease diagnosis;dosage;Dyes;Environment;Excision;Exhibits;experience;FDA approved;Fluorescence;fluorescence imaging;Fluorescent Dyes;Fluorescent Probes;Future;Goals;Head and Neck Cancer;Head and Neck Neoplasms;Head and neck structure;Head and Neck Surgery;Histology;Image;Image-Guided Surgery;imaging agent;imaging biomarker;Imaging Device;imaging modality;imaging platform;imaging system;Imaging Techniques;improved;Indocyanine Green;Injections;Institutional Review Boards;Label;Light;light intensity;Liver;malignant mouth neoplasm;Malignant Neoplasms;Maps;Measurement;Methods;Microscopy;Modeling;Mohs Surgery;Molecular Target;nanosecond;Normal tissue morphology;novel;novel strategies;Oncology;Operative Surgical Procedures;optical imaging;Optics;Palpation;Pathology;Patient Schedules;Patients;Penetration;phantom model;portability;pre-clinical;Pre-Clinical Model;preclinical study;receptor;Recurrent disease;Sensitivity and Specificity;soft tissue;Solid;Specimen;Standardization;Survival Rate;System;targeted imaging;Time;Tissue Stains;Tissues;tool;Translating;tumor;tumor specificity;Tumor Tissue;uptake;Validation;Visual;Visualization;Width

PROJECT_TITLE: Fluorescence lifetime-based tumor contrast enhancement using exogenous probes

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Microbiome;Neurosciences;Pain Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Irritable bowel syndrome (IBS) affects ~11% of the population worldwide, significantly impacts patients’ quality of life and imposes a tremendous economic burden due to loss of productivity and high healthcare costs due ot its relapsing-remitting nature. Abdominal (visceral) pain is the defining IBS symptom and is also the hardest to treat. Changes in small intestinal bacteria are associated with abdominal pain, but the mechanism by which they cause visceral pain remains unclear; this is a significant roadblock for developing effective treatments. Our proposal will uncover how specific small intestinal bacterial products can cause abdominal pain and allow development of effective probiotic and other therapies to treat abdominal pain in patients with IBS.

PI_NAMEs: BEYDER, ARTHUR ;KASHYAP, PURNA C (contact);SMITH-EDWARDS, KRISTEN MICHELLE

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: 16S ribosomal RNA sequencing;Abdomen;Abdominal Pain;Acetates;Acute;Address;Affect;Afferent Neurons;Animal Model;Bacteria;Cell model;Central Nervous System;Chemicals;Chest;Chronic;Colon;colon bacteria;Data;Dedications;Dependovirus;design;Development;Diagnostic;Diffuse;Disease;Disease remission;Economic Burden;effective therapy;Electrophysiology (science);Enterobacter;Enterobacteriaceae;Enterochromaffin Cells;Epithelial Cells;Exposure to;Feces;Frequencies;Functional disorder;ganglion cell;gastrointestinal symptom;genome sequencing;Germ-Free;Growth;gut microbes;gut microbiome;gut microbiota;Health Care Costs;Human;Hypersensitivity;Image;Individual;Irritable Bowel Syndrome;Klebsiella pneumoniae;Knowledge;mechanical stimulus;Mechanics;microbial;microbial composition;microbial products;microbiome;Modeling;Molecular;Mus;Nature;nerve supply;neural;Neuroepithelial;Neurons;neurotransmitter release;Neurotransmitters;new therapeutic target;novel;novel strategies;optogenetics;Organoids;Outcome;Pain;Pathology;Pathway interactions;Patients;Physiological;Population;Preparation;Probiotics;productivity loss;Quality of life;Relapse;response;Role;Sampling;Sensory;sensory input;Serotonin;Signal Transduction;Site;Small Intestines;Spinal Cord;Spinal Ganglia;Stimulus;Structure;Symptoms;Testing;testing access;Therapeutic;tool;Transducers;Transgenic Mice;transmission process;Tyrosine;Visceral;Visceral pain;whole genome

PROJECT_TITLE: MECHANISMS OF VISCERAL PAIN DRIVEN BY SMALL INTESTINAL MICROBIOTA


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Myelodysplastic syndrome (MDS) is a lethal disease with relatively limited therapeutic options, leading to high patient mortality. The overall goal of this project is to identify novel therapeutic regimens that more effectively target heterogeneous malignant stem cell populations that give rise to MDS. These studies stand to substantially improve the efficacy and safety of current therapeutic regimens targeting MDS stem cells, and overall improve outcomes for patients with MDS.

PI_NAMEs: PIETRAS, ERIC M (contact);STEVENS, BRETT M

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Address;Aftercare;Automobile Driving;Azacitidine;Behavior;Biological;Biological Assay;cancer stem cell;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Trials;Clone Cells;cohort;Coupled;Data;design;Disease;Disease Progression;Dose Limiting;Dysmyelopoietic Syndromes;Foundations;genetic approach;Genotype;Goals;Hematopoietic stem cells;Heterogeneity;high risk;Hydrogenase;improved;improved outcome;In complete remission;in vivo;Individual;inhibitor;Laboratories;Laboratory Study;Link;Metabolic;Modality;Modeling;Molecular;Molecular Genetics;mortality;Myelogenous;next generation;Niacinamide;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Proliferating;Property;Protein Biosynthesis;Protein Synthesis Inhibition;Protein Synthesis Inhibitors;Proteins;rational design;Recurrent disease;Regimen;Research Personnel;Residual Neoplasm;Resistance;Resolution;response;Safety;Signal Pathway;Specimen;standard of care;STAT3 gene;stem cell population;stem cells;Therapeutic;Toxic effect;Translational Repression;Translations;treatment response;Vertebral column;Work

PROJECT_TITLE: Metabolic targeting of heterogenous myelodysplastic syndrome stem cells

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


NIH_SPENDING_CATS: Clinical Research;Cocaine;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Cocaine use is an important topic and is one of the most commonly used drugs in the US, especially in the south, and promotes both initiation and elongation phase of HIV-1 transcription and may affect HIV reservoir activation. Cocaine use is associated with increased inflammation and mortality in antiretroviral treated HIV. This proposal will investigate the mechanisms of host gene isoform expression on functional cure of HIV in cocaine users, which may reveal a novel mechanism on controlling of HIV persistence and help the development of therapeutic strategy for ART-free HIV cure in cocaine users and non-drug users.

PI_NAMEs: JIANG, WEI ;ZHU, JIAN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Affect;Alternative Splicing;Anti-Retroviral Agents;antiretroviral therapy;Binding;Biological Assay;brain tissue;CD4 Positive T Lymphocytes;Cells;Chemicals;Chronic;chronic infection;clinically significant;Cocaine;cocaine use;Cocaine Users;CREB1 gene;CREM protein;Cyclic AMP;digital;Dinoprostone;Disease Progression;DNA Markers;Dose;Drug abuse;Drug usage;Drug user;Exons;Frequencies;Gene Expression Profile;Generations;Genes;Genetic Transcription;HIV;HIV Infections;HIV resistance;HIV-1;HIV/AIDS;Immune;improved;In Vitro;Individual;Infection;Inflammation;inflammatory marker;Inflammatory Response;Integration Host Factors;Investigation;IRF3 gene;knock-down;Knock-out;Length;Measures;Mediating;Methods;Microglia;monocyte;mortality;NF-kappa B;non-drug;novel;nuclear factors of activated T-cells;overexpression;Pathogenesis;Patient Recruitments;Phase;Population;potential biomarker;prevent;prospective;Protein Isoforms;Residual state;resistance mechanism;RNA Splicing;Role;Signal Transduction;Testing;therapeutic development;Tissue Sample;Tissue-Specific Gene Expression;transcription factor;transcriptome sequencing;Validation;Variant;Viral;Viral Load result;Viral reservoir;Virus;Virus Replication;Withdrawal

PROJECT_TITLE: Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine Users


ADMINISTERING_IC: AA

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Digestive Diseases;Nutrition;Obesity;Prevention;Substance Misuse

ORG_CITY: CHAMPAIGN

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: Although bariatric surgery procedures provide the most successful long-term treatments for obesity and are associated with numerous health benefits, there is increasing concern about the development of alcohol problems with the two most-used procedures (i.e., sleeve gastrectomy and gastric bypass). The results from our study will lay the foundation for understanding how sleeve gastrectomy, the most performed bariatric surgery, affects how alcohol is processed by the body and how alcohol affects mood and blood sugar in both men and women. These evidence-based data will support patient counseling and monitoring and may help prevent alcohol misuse after bariatric surgery.

PI_NAMEs: PEPINO DE GRUEV, MARTA YANINA (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol misuse prevention;alcohol response;alcohol risk;alcohol testing;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;American;bariatric surgery;Bariatrics;Biological Availability;Blood alcohol level measurement;Blood Circulation;Blood Glucose;Body mass index;Clinical Practice Guideline;Closure by clamp;comparison control;Consumption;Control Groups;Counseling;Cross-Sectional Studies;Data;Development;Disease;disorder risk;Dose;drinking;Drug Kinetics;Ethanol Metabolism;Ethnic Origin;evidence base;evidence based guidelines;Exclusion;Fasting;Fatty acid glycerol esters;feeding;Food;Foundations;Funding;Gas Chromatography;Gastrectomy;Gastric Bypass;Gastric Emptying;Gluconeogenesis Inhibition;Glucose;Goals;Grant;Health Benefit;Hormonal;Hour;Human;Hypoglycemia;Ingestion;innovation;Insulin;Intoxication;Intravenous;Kinetics;knowledge base;Liver;Measures;men;Metabolism;Modeling;Monitor;Moods;nutrient absorption;Obesity Epidemic;obesity treatment;Operative Surgical Procedures;Oral;Oral Administration;Participant;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Procedures;Process;Questionnaires;Race;Radioimmunoassay;Randomized;Reactive hypoglycemia;Research;response;Risk;sedative;sex;Sex Differences;Site;Stomach;Subgroup;Testing;Time;Toxic effect;United States;United States National Institutes of Health;Venous blood sampling;Woman;Women's study

PROJECT_TITLE: Pharmacokinetics and Responses to Alcohol After Bariatric Surgery

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: LUNA LABS USA, LLC

ORG_STATE: VA

PHR: PROJECT NARRATIVE A two component sprayable hydrogel barrier that has been previously demonstrated to reduce abdominal adhesion formation will be investigated for the prevention of uterine adhesions following cesarean delivery. The implications of this study are significant as the rate of cesarean delivery now accounts for more than one third of live births, with a particularly high rate observed within minority communities. This Direct Phase II effort will target the demonstration of product safety and efficacy to support uterine healing while mitigating adverse scar or adhesion formation, improving postoperative outcomes for women at higher risk of maternal morbidity or mortality.

PI_NAMEs: COSTELLA, LAUREN  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Abdomen;Address;Adhesions;Adopted;African American;Age;Alginates;biomaterial compatibility;Biotechnology;Birth;Black race;black women;Cattle;Cesarean section;Chitosan;Cicatrix;Clinical;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Confined Spaces;Contracts;Development;Diabetes Mellitus;Disparity;disparity reduction;Education;Evaluation;experience;Film;first-in-human;Formulation;Funding;Goals;Government;Gynecologic;healing;High Risk Woman;Histopathology;Human;Hydrogels;Hypertension;improved;Incidence;Individual;Infertility;injured;Insurance;interest;Investments;Legal patent;Live Birth;Maintenance;Marketing;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Measurable;Medicaid;meetings;minority communities;Minority Groups;Modeling;Mothers;mouse model;Mus;Myometrial;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Pain;Patients;payment;Pelvis;Phase;Polymers;Population;Postoperative Complications;Postoperative Period;preclinical efficacy;Pregnancy;pregnant;prevent;Prevention;Procedures;programs;Quality of Care;Rattus;Reporting;Research Contracts;Risk;Safety;Severities;Shapes;Sodium;Solid;Source;Strategic Planning;Surface;Surgical complication;Surgical incisions;Target Populations;Technology;Testing;Time;Tissues;treatment group;Uterine Rupture;uterine smooth muscle cell;Uterus;Validation;Water;White Women;Woman;women's outcomes;Work;wound healing

PROJECT_TITLE: Improving Maternal Outcomes of Cesarean Delivery with the Prevention of Postoperative Adhesions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: AUGUSTA

ORG_DEPT: PEDIATRICS

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: The goal of this project is to characterize the mechanism by which excess heme exposure alters the tricarboxylic acid (TCA) cycle activity to affect the ferroptosis stress, while Nrf2 renders protective effects against this heme-induced metabolic stress to regulate the pathophysiology of sickle cell disease. We will determine the hemin/Nrf2 mediated metabolic, epigenetic and ferroptotic stress response in controlling the cellular fate of erythroid cells under hypoxia and the findings will implicate Nrf2 activation and metabolic regulation as novel treatment options for sickle cell disease.

PI_NAMEs: ZHU, XINGGUO  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Ablation;Affect;alpha ketoglutarate;Anemia;Animal Disease Models;Apoptosis;biological adaptation to stress;Catabolism;CD34 gene;Chromatin Structure;Chronic;Citric Acid Cycle;Complex;Dioxygenases;Disease;Disease Progression;Drug Metabolic Detoxication;Epigenetic Process;epigenetic regulation;Erythroblasts;Erythrocytes;Erythroid Cells;Erythropoiesis;Fumarates;Functional disorder;Gene Expression;Generations;Genes;genomic locus;Glutathione Metabolism Pathway;Glycolysis;Goals;Hematopoietic stem cells;Heme;heme oxygenase-1;Hemin;Hemolysis;histone demethylase;histone methylation;histone modification;Histones;Hypermethylation;Hypoxia;Impairment;Individual;Inflammation;Iron;iron metabolism;Ketoglutarate Dehydrogenase Complex;Lysine;Mediating;Metabolic;Metabolic stress;Metabolism;metabolome;Modification;mouse model;Mus;novel;nuclear factor-erythroid 2;Nucleotides;Outcome;Oxidative Stress;Patients;Persons;Play;pre-clinical;programs;protective effect;Regulation;Regulatory Pathway;response;Role;Route;Severities;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Signal Pathway;Signal Transduction;Stress;Testing;Therapeutic;transcriptome

PROJECT_TITLE: Heme-induced metabolic stress drives ferroptosis in sickle cell disease

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ORG_CITY: NEW HAVEN

ORG_NAME: ATLASXOMICS INC.

ORG_STATE: CT

PHR: Project Narrative  Disease often involves cells of multiple types and is accompanied by changes in the composition, structure, and organization of tissues. AtlasXomics is developing a research tool to help researchers understand the spatial modulation of gene expression in tissue, and the epigenetic dysregulation common in cancer and cardiovascular disease.

PI_NAMEs: SABINA, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Address;Adoption;Anatomy;Area;ATAC-seq;Bar Codes;Binding;Bioinformatics;bioinformatics tool;Biological;Biological Assay;Biology;Biomedical Research;Biotechnology;Brain;brain tissue;Cancer Biology;cancer therapy;Capital;Cardiac;Cardiovascular Diseases;cardiovascular disorder therapy;Cause of Death;Cell Communication;Cells;Chromatin;Closure by clamp;Collaborations;commercial application;commercialization;Complex;computational pipelines;Computer software;computerized data processing;cost;Custom;Cutaneous Lymphoma;Data;Data Analyses;data analysis pipeline;data exploration;data integration;Data Set;Democracy;design;Development;Dimensions;Disease;Disease Progression;DNA;DNA sequencing;effective therapy;Elements;Embryo;Epigenetic Process;epigenome;epigenomics;Equipment;Feedback;Gene Expression;Genetic;Genetic Transcription;Genome;genome-wide;Germinoma;Goals;Grant;healthcare burden;Human;Immune;immune cell infiltrate;improved;Industry Standard;innovation;insight;interest;Location;Malignant Neoplasms;Manuals;Manuscripts;Maps;Marketing;Melanoma;Methods;Microfluidic Microchips;Microfluidics;Mus;next generation;next generation sequencing;novel;novel strategies;Pathology;patient response;Performance;Phase;Phenotype;Play;Population;Positioning Attribute;Price;prognostic tool;Proteomics;Protocols documentation;Publications;Reproducibility;Research;Research Personnel;Resistance;Resolution;RNA;Role;Running;Sampling;Scientist;Site;Small Business Innovation Research Grant;Spottings;Standardization;Structure;Technology;therapeutic effectiveness;therapy resistant;Time;Tissues;tool;Training;transcription factor;transcriptome sequencing;transcriptomics;Transposase;treatment response;tumor;tumor microenvironment;Universities;Untranslated RNA;user-friendly;XCL1 gene

PROJECT_TITLE: A democratized platform for mapping the spatial epigenome in tissue