NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebral Palsy;Childhood Injury;Clinical Research;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rehabilitation;Unintentional Childhood Injury

PHR: Project Narrative Intrauterine growth restriction (IUGR) results in an increased risk of mortality and cardiopulmonary and neurologic morbidities including cerebral palsy (CP) in neonates. Currently the relationship between perinatal brain injury, neuromuscular deficits, and functional motor abnormalities in CP is poorly understood. In this project, we will utilize a mouse model of IUGR with/without postnatal hyperoxia exposure to investigate cell specific changes to the oligodendrocyte transcriptome leading to pathologic changes to the corticospinal tract and motor deficits similar to those seen in CP

PI_NAMEs: CHANG, JILL  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 2',3'-Cyclic-Nucleotide Phosphodiesterases;3-Dimensional;Acceleration;Adult;Affect;Anatomy;Biochemical;Bioinformatics;Biomedical Engineering;Biometry;Birth Weight;Brain;Brain Injuries;Brain region;Brain Stem;Cardiopulmonary;Cell Death;Cells;Cerebral Palsy;Cerebrum;Corticospinal Tracts;Demyelinations;Development;differential expression;Diffusion;Diffusion Magnetic Resonance Imaging;Distal;Down-Regulation;Dyskinetic syndrome;Electromyography;Environment;Exposure to;Extensor;Faculty;Fetal Growth;Fetal Growth Retardation;Fiber;Flexor;Foundations;Future;Gait abnormality;Genes;Genetic;Genetic Transcription;Gestational Age;Human;Hyperoxia;Hyperreflexia;Image;imaging modality;Imaging Techniques;in vivo;in vivo imaging;Infant;Injury;innovation;insight;Investigation;Joints;kinematics;Knowledge;Learning;Lesion;limb movement;Limb structure;Locomotion;Magnetic Resonance Imaging;Manuscripts;Mentors;Mentorship;Messenger RNA;Methods;Modeling;Modification;Morbidity - disease rate;mortality risk;Motor;motor deficit;motor disorder;motor impairment;mouse model;Movement;Mus;Muscle;Myelin;myelination;neonatal patient;neonate;Nervous System Trauma;Neurologic;neuromuscular;neuromuscular function;next generation sequencing;novel;novel therapeutic intervention;Oligodendroglia;Ontology;Pathologic;Pathway interactions;Perinatal;Perinatal Brain Injury;Phenotype;Physical therapy;Positioning Attribute;postnatal;Predisposition;Pregnancy;Preparation;Recording of previous events;Research;Research Personnel;response;Ribosomes;RiboTag;Risk;RNA;Spasm;Spastic Cerebral Palsy;Spinal Cord;Technical Expertise;Techniques;Testing;Therapeutic Intervention;Thromboxane A2;Time;Transcript;transcriptome;transcriptomics;white matter;white matter injury

PROJECT_TITLE: Corticospinal Tract Development in Intrauterine Growth Restriction

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE CD4+Foxp3+ regulatory T cells (Tregs) residing in the visceral adipose tissue (VAT) safeguard tissue homeostasis and promote insulin sensitivity but are sensitive to obesity-induced toxicity. This proposal seeks to uncover novel metabolic and cytokine-mediated mechanisms that control the homeostasis of VAT Tregs and determine how these pathways might be dysregulated during obesity. A better understanding of these mechanisms should aid us to devise efficient and long-lasting VAT-Treg-targeted strategies to ameliorate obesity-associated metabolic diseases, including type-2 diabetes, fatty-liver disease, and cardiovascular disorders.

PI_NAMEs: LI, CHAORAN  (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Ablation;Address;Adipose tissue;Adoptive Transfer;Adult;Affect;Antigen Receptors;biochemical tools;Body mass index;Cardiovascular Diseases;Cells;Characteristics;Child;Cholesterol;Cholesterol Homeostasis;Chronic;Chronic Disease;Clone Cells;Couples;cytokine;Data;Development;Diet;diet-induced obesity;Environment;Estrogen deficiency;estrogen disruption;Estrogens;experimental study;fasting glucose;fatty liver disease;feeding;Female;FOXP3 gene;Gene Expression Profile;Genes;Genetic;Goals;Gonadal Steroid Hormones;Health;High Fat Diet;Homeostasis;Human;IFNAR1 gene;Immune;in vivo;Inflammation;Insulin Resistance;insulin sensitivity;Interferon alpha;Interferon Type I;Knowledge;Learning;Lymphoid Tissue;male;Mediating;men;Metabolic;Metabolic Diseases;Metabolic hormone;Metabolic syndrome;mevalonate;Modeling;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Obesity;Omentum;Outcome;Ovarian;Pathway interactions;Phenotype;Population;Postmenopause;Prevalence;Regulation;Regulatory T-Lymphocyte;response;Risk;Role;sex;Signal Transduction;Supplementation;System;systemic inflammatory response;T cell therapy;T-Cell Receptor;Thinness;Tissues;tool;Toxic effect;Transcript;transcriptome;transcriptomics;Transgenic Mice;uptake;Visceral;Woman

PROJECT_TITLE: Cytokine and Metabolic Regulation of Adipose-tissue Tregs

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT 2 NARRATIVE There is an urgent need to develop novel, low-cost and technologically feasible approaches for cervical screening, diagnosis, and treatment for women living with HIV (WLWH) in low- and middle-income countries (LMICs). The goal of Project 2 is to evaluate a novel optical microscope with a deep depth of field (DeepDOF) which can provide histologic-quality images at the point-of-care and prevent delays in diagnosis and initiation of treatment. The study will be performed in Mozambique and Brazil where the prevalence of cervical cancer in WLWH is high.

PI_NAMEs: LORENZONI, CESALTINA FERREIRA (contact)

PROJECT_TERMS: Ablation;Acetic Acids;Address;Advanced Development;AIDS related cancer;Behavioral Sciences;Biomedical Engineering;Biopsy;Brazil;Cancer Etiology;cancer invasiveness;career;Caring;Categories;cervical biopsy;Cervical Cancer Screening;Cervical dysplasia;Characteristics;Clinical;co-infection;Cold Therapy;Collaborations;comorbidity;cost;Country;Development;Diagnosis;Diagnostic;diagnostic technologies;digital;digital healthcare;Disease;DNA;Epidemiology;Equipment;Evaluation;Excision;Face;follow-up;Fresh Tissue;Funding;Goals;Gynecologic Oncologist;Gynecologist;Hematoxylin and Eosin Staining Method;Histologic;Histopathology;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Human Papillomavirus;Human Resources;Image;Infrastructure;Institution;Lesion;loop electrosurgical excision procedure;low and middle-income countries;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mentors;Methods;Microscope;Mozambique;multidisciplinary;new technology;novel;Nurses;Operative Surgical Procedures;Optics;Pathologist;Pathology;Performance;Pilot Projects;point of care;point-of-care diagnostics;premalignant;Prevalence;prevent;Prevention;Prevention approach;programs;prospective;psychosocial;Reagent;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Resource Sharing;Resource-limited setting;Risk;Risk Factors;screening program;Slide;social stigma;Specialist;standard of care;Surgical margins;Technology;Testing;Texas;Thermal Ablation Therapy;Time;tissue processing;treatment planning;United States National Institutes of Health;Vision;Visit;Visual;Woman;Women's cohort;women's treatment

PROJECT_TITLE: Project 2


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Sleep Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Despite the efficacy of electroconvulsive therapy (ECT) in alleviating symptoms in patients with Treatment- Resistant Depression (TRD), memory impairment remains a common side effect. The goal of this study is to assess the impact of ECT on sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal. A thorough understanding of the underlying circuit mechanisms by which ECT works will allow enhancement of its utility through improvement of clinical outcomes and reduction of cognitive impairments following this critical treatment.

PI_NAMEs: KAFASHAN, MOHAMMADMEHDI  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Accounting;Adult;Age;anti-depressive agents;antidepressant effect;Arousal;awake;Biological Markers;Bipolar Depression;Brain;career;Clinic;Clinical;Cognition;Cognitive;cognitive function;density;depressive symptoms;Development;disability;Dryness;economic cost;effective intervention;Electroconvulsive Therapy;Electrodes;Electroencephalography;Episodic memory;Eye;Frequencies;functional plasticity;General Anesthesia;Generalized seizures;Goals;Graph;Homeostasis;Impaired cognition;improved;indexing;Individual;information processing;innovation;insight;Intervention;inventory of depressive symptomatology;Investigation;Length;Longitudinal Studies;Major Depressive Disorder;Measures;Memory;Memory impairment;Mental Depression;Mental disorders;Modeling;neural;Neuronal Plasticity;neuropsychiatry;non rapid eye movement;Outcome;Outpatients;Pathology;Pathway Analysis;Patient-Focused Outcomes;Patients;Performance;pharmacologic;Play;Procedures;prognostic;Property;psychiatric symptom;Psychiatry;Public Health;recruit;reduce symptoms;Regulation;Research;response;Rest;Role;Seizures;Severities;sex;Short-Term Memory;side effect;Signal Transduction;Sleep;sleep abnormalities;Sleep disturbances;Sleep Stages;Slow-Wave Sleep;Sorting;stem;Structure;Synapses;Synaptic plasticity;Technology;therapeutic target;treatment-resistant depression;United States National Institutes of Health;Wakefulness;wearable device;wireless;Work

PROJECT_TITLE: Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

PHR: NARRATIVE: The Shared Resource Core (SRC) will support the Research Projects of the AVANÇO Research Consortium as well as the Pilot Projects of the associated Developmental Core. The SRC will provide uniform and high-quality methods for the acquisition, storage and analysis of biospecimens and study data, including cervical and pathology images. Centralizing oversight of these operational procedures and processes through the SRC will allow for high-quality and secure data, efficient use of both laboratory and human resources, as well as the creation of a central data repository for AVANÇO Research Consortium investigators across Mozambique, Brazil and the US.

PROJECT_TERMS: Address;Advanced Development;AIDS related cancer;Algorithms;Behavioral Sciences;Biomedical Engineering;Biopsy Specimen;Blood specimen;Brazil;Cancer Center;career;Categories;Cervical;cervical biopsy;Cervical Cancer Screening;Cervical dysplasia;Characteristics;Clinic;Clinical;Clinical Data;co-infection;Collaborations;Collection;college;Colposcopes;comorbidity;Complex;Computers;Consensus;cost;Country;Data;data repository;data sharing;Databases;Development;Diagnosis;Doctor of Philosophy;electronic data;Engineering;Epidemiology;Funding;Goals;Health Sciences;Histologic;Histopathology;HIV;HIV Infections;HIV/AIDS;Hospitals;Human Resources;Image;Image Analysis;Infrastructure;Institution;Laboratories;Leadership;Link;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicine;Mentors;Methods;Microscope;Mozambique;multidisciplinary;multimodality;new technology;novel;novel imaging technology;Optics;overtreatment;Pathologist;Pathology;pathology imaging;Performance;Pilot Projects;point of care;prevent;Prevention;Prevention approach;Procedures;Process;programs;quality assurance;Radiation Oncologist;Research;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resource Sharing;Rice;Risk;Risk Factors;Secure;Site;Standardization;stool sample;Swab;Technology;Testing;Texas;Tissue imaging;Training;Triage;United States National Institutes of Health;Universities;Vision;Woman;women's treatment

PROJECT_TITLE: Shared Resources Core


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

PHR: The overall goal of the AVANÇO Research Consortium Developmental Core is to identify, recruit, and mentor junior investigators from Mozambique, Brazil and the US to conduct research in HIV-associated malignancies in low- and middle-income countries (LMICs). We will provide pilot project funding to support career development as well as twice annual Research Training Courses, one in Mozambique and one in Brazil, to build research capacity. We will support and mentor junior investigators through implementation of a Project ECHO® program for research capacity building.

PI_NAMEs: CHIAO, ELIZABETH Y. (contact)

PROJECT_TERMS: Address;Advanced Development;AIDS related cancer;Area;Award;Behavioral;Behavioral Sciences;Biomedical Engineering;Brazil;Cancer Center;cancer therapy;career;career development;Categories;cervical cancer prevention;Cervical Cancer Screening;Cervical dysplasia;Clinical;clinical care;Clinical Research;co-infection;Collaborations;college;Communities;comorbidity;cost;Country;Data Analyses;Development;Diagnosis;Discipline;Discipline of obstetrics;Education;Eligibility Determination;Epidemiology;Ethics;experience;Faculty;Feedback;Fellowship;flexibility;Fostering;Funding;Goals;Grant;Gynecologic Oncology;Gynecologic Pathology;Gynecology;HIV;HIV Infections;HIV/AIDS;Hospitals;Hour;human subject protection;Image;Image Analysis;implementation science;improved;Infrastructure;innovation;Institution;interest;Laboratories;Laboratory Research;Language;lectures;Life;low and middle-income countries;Low income;Machine Learning;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medicine;member;Mentors;Mentorship;Methods;Mozambique;multidisciplinary;novel;Oncology;Participant;Pathology;Persons;Physicians;Pilot Projects;Portuguese;Prevention;Prevention approach;programs;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Research Training;Residencies;Resource Sharing;Rice;Risk;Risk Factors;Scientist;skills;survivorship;Technology;Texas;Time;Training;training opportunity;Translational Research;United States National Institutes of Health;Universities;videoconference;virtual;Vision;Woman;women's treatment;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Palliative Care;Patient Safety;Prevention

ORG_CITY: CHICAGO

ORG_NAME: ALLIANCE NCTN FOUNDATION

ORG_STATE: IL

PHR: Alliance NCORP Research Base Project Narrative The Alliance NCI Community Oncology Research Program (NCORP) Research Base conducts research in cancer prevention, cancer symptom control, and cancer care delivery with a special emphasis on minority, underserved, and older patients and with a strong commitment to building collegial relationships with NCORP Community sites and Minority/Underserved Community sites. The Alliance NCORP seeks to continue its mission into the next grant cycle of generating practice-changing research that directly and favorably impacts the lives of cancer patients and those at risk for cancer.

PI_NAMEs: GALANIS, EVANTHIA ;HAHN, OLWEN ;PASKETT, ELECTRA D. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Academic Medical Centers;Address;Advocate;Aging;Area;Attention;base;Behavior;Blood;Cancer Burden;cancer care;cancer clinical trial;cancer health disparity;Cancer Patient;cancer prevention;Cancer Research Project;cancer risk;cancer therapy;care delivery;Caregivers;chemotherapy;Clinical;Clinical Oncology;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Collaborations;Collection;Committee Membership;Communities;Community Clinical Oncology Program;community engagement;Companions;curative treatments;Data;Data Reporting;data sharing;Databases;Development;Diagnosis;Disease;Disparity;disparity elimination;disparity reduction;Early Diagnosis;Education;experience;financial toxicity;forging;Functional disorder;Funding;Funding Opportunities;Grant;Health;health disparity;high risk;Human;improved;Incidence;innovation;Intervention;Maintenance;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Minority;Minority Groups;Mission;Monitor;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;National Clinical Trials Network;Natural History;Nausea and Vomiting;next generation;novel;older adult;older patient;Oncologist;Oncology;Outcome;Outcome Assessment;Outcomes Research;Parents;Patient Outcomes Assessments;Patients;Pharmacologic Substance;Population;premalignant;Prevalence;prevent;Prevention;programs;Publishing;Quality of life;reduce symptoms;repository;Research;Research Methodology;Research Personnel;Research Priority;Risk;Site;skeletal-related events;Source;survivorship;Symptoms;Technology;Tissue Sample;Toxic effect;Training;translational oncology;Translational Research;treatment trial;Tumor Tissue;underserved community;Underserved Population;United States;Work

PROJECT_TITLE: Alliance NCORP Research Base


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Heart Disease;Palliative Care;Patient Safety;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE High medication burden among older adults with multiple chronic conditions including those with heart failure is a growing problem in the United States that can negatively impact the health and wellbeing of older adults. Deprescribing (or medication discontinuation) has emerged as a strategy to improve outcomes in older adults with multiple chronic conditions and high medication burden, but is underutilized. With this proposed project, we will develop an innovative pragmatic patient-centered approach (N-of-1 trials) to medication optimization in older adults, thereby improving the health and wellbeing of older adults with multiple chronic conditions.

PI_NAMEs: GOYAL, PARAG  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adrenergic beta-Antagonists;Adverse event;Affect;Aging;aging population;American;Area;Attention;Belief;Benefits and Risks;Biological;Biometry;Cardiac Output;Cardiology;career;career development;Caring;clinical practice;Clinical Trials;college;Communication;Complex;Crossover Design;Data;Death Rate;Decision Making;Development;Drug Prescriptions;drug withdrawal;Effectiveness;effectiveness-implementation RCT;effectiveness/implementation hybrid;effectiveness/implementation trial;EFRAC;Elderly;Ensure;Environment;Event;experience;Experimental Designs;Foundations;Funding;Future;Geriatrics;Goals;Grant;Health;Health Priorities;Heart;Heart failure;hospitalization rates;Impairment;implementation science;improved;improved outcome;Individual;individual patient;innovation;Intervention;iterative design;Knowledge;Knowledge acquisition;Lead;Left;Life Expectancy;Manuscripts;Medication Management;Medicine;Mentors;Mentorship;multiple chronic conditions;novel;Office Visits;older adult;Outcome;Participant;patient oriented;Patient Outcomes Assessments;Patients;Personal Satisfaction;Pharmaceutical Preparations;Polypharmacy;Population;Population Study;Positioning Attribute;Precision therapeutics;preference;preservation;prevent;Principal Investigator;Process;programs;Protocols documentation;prototype;Randomized, Controlled Trials;Research Personnel;Research Project Grants;Role;shared decision making;Signal Transduction;skills;success;supportive environment;Syndrome;Testing;theories;Time;Training;Uncertainty;United States;Variant;Ventricular;working group

PROJECT_TITLE: A Novel Deprescribing Intervention for Heart Failure with Preserved Ejection Fraction (HFpEF): A Prototype for Older Adults with Multimorbidity and Polypharmacy


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE There are now hundreds of thousands of people enrolled in biobank studies, presenting unprecedented opportunities for understanding the genetic basis of vulnerability to disease and other complex traits. Novel computational methods from population genetics allow these vast genetic datasets to be expressed in terms of genealogical relationships among segments of DNA scattered across people, which naturally encodes all historical information available in a set of contemporary genomes, as well as all correlations among genetic variants. We will use these new resources to understand the evolution of complex biomedical traits and better identify genetic variants associated with disease.

PI_NAMEs: EDGE, MICHAEL DONALD (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: biobank;Biomedical Research;causal variant;Complex;computerized tools;Computing Methodologies;Data;Data Set;Disease;Disease susceptibility;Distant;DNA;Enrollment;Ensure;Etiology;Evolution;Genealogy;Genetic;Genetic Databases;genetic evolution;Genetic Recombination;Genetic Research;genetic variant;Genome;genome wide association study;genome-wide;genomic locus;Genomic Segment;Genomics;Genotype;Goals;Graph;Heritability;Human Genetics;Learning;Leg;Maps;Methods;novel;Participant;Partner in relationship;Persons;Phenotype;phenotypic data;Population;Population Genetics;population stratification;Privacy;privacy protection;programs;public trust;Research;Resources;Sampling;Statistical Methods;theories;Time;tool;trait;Trees;Variant

PROJECT_TITLE: Traits on trees: Population genomics for understanding complex phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Effective management of patients on antiretroviral therapy (ART) is essential to improve patient outcomes and prevent HIV transmission, but monitoring life-long ART for over 13 million HIV-infected people has become a challenge, particularly in low- and middle-income countries (LMICs). In this study, we will evaluate a combined implementation of clinic-based point-of-care HIV viral load testing and task shifting among healthcare workers as a novel and effective strategy for managing chronic HIV care in LMICs. Our intervention will allow the most highly-trained professionals and laboratories to focus on people with new HIV diagnoses, those starting ART, and those with complication of HIV or ART, which will facilitate the expansion of ART to reach the estimated millions people who are eligible.

PI_NAMEs: DRAIN, PAUL K (contact);GARRETT, NIGEL JOEL

PROGRAM_OFFICER_NAME: OJUMU, AKINLOLU O

PROJECT_TERMS: Adherence;antiretroviral therapy;arm;Behavior Therapy;Biological Assay;Caring;Chronic;Clinic;Clinical;clinical efficacy;clinical research site;Clinical Trials;Collaborations;Complement;Complication;cost;cost effective;cost effectiveness;cost estimate;Data;Development;Diagnostic;disability-adjusted life years;economic impact;efavirenz;Effectiveness;Eligibility Determination;Ensure;Evaluation;experience;Focus Groups;Goals;Health;Health Personnel;HIV;HIV diagnosis;implementation science;implementation trial;improved;Intervention;intervention cost;Laboratories;low and middle-income countries;Methods;microcosting;Modeling;Monitor;novel;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Persons;Pilot Projects;point of care;point of care testing;Policies;prevent;Principal Investigator;process evaluation;Provider;Qualifying;Questionnaires;Randomized;Regimen;Research;Services;Social Behavior;South Africa;South African;standard of care;Structure;Tenofovir;Testing;therapy adherence;Time;Training;transmission process;treatment as usual;Treatment outcome;Urine;Validation;Viral;Viral Load result;Viremia

PROJECT_TITLE: Simplifying HIV Treatment and Monitoring (STREAM2):  Point-of-Care Urine Tenofovir Adherence and Viral Load Testing to Improve HIV Outcomes in South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Heart Disease;Prevention;Stroke

ORG_CITY: CLEVELAND

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Atrial fibrillation, with prevalence in the United States predicted to increase to 12.1 million patients by 2030, is a powerful risk factor for blood clots and stroke, independently increasing stroke risk 4- to 5-fold. This project aims to improve the stroke prevention treatment for atrial fibrillation by transforming Left Atrial Appendage Occlusion procedures into a first line therapy for a larger segment of patient populations, including, younger patients with 20+ year of life expectancy. The proposed research study aims to achieve this goal by combining novel medical imaging, robotic catheter, and advanced visualization technologies to improve the safety, cost, and workflow of Left Atrial Appendage Occlusion procedures.

PI_NAMEs: BEZERRA, HIRAM ;CAVUSOGLU, M. CENK  (contact);GRISWOLD, MARK ;SEIBERLICH, NICOLE

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Age;Algorithms;anatomic imaging;Anatomy;Animals;Anticoagulation;Area;Arrhythmia;Atrial Fibrillation;auricular appendage;Blood coagulation;Cardiac;cardiac magnetic resonance imaging;Cardiology;Catheters;Cessation of life;Chronic;Clinical;Clinical Research;comparative efficacy;cost;cost effective;Data;Data Collection;design and construction;Detection;Development;Devices;efficacy study;experience;experimental study;Exposure to;flexibility;Fluoroscopy;Goals;heart imaging;Hemorrhage;Hospitalization;Human;Human Resources;human subject;Image;image guided;Implant;Implantation procedure;improved;in vivo;Intervention;Intracranial Hemorrhages;Ionizing radiation;Left;Life Expectancy;Location;magnetic field;Magnetic Resonance Imaging;Mechanics;Medical Imaging;Methods;minimally invasive;new technology;novel;novel strategies;Operative Surgical Procedures;Oral;patient population;Patients;Performance;Pharmaceutical Preparations;Physicians;Positioning Attribute;pre-clinical;Prevalence;prevent;Prevention therapy;Probability;Procedures;prototype;Puncture procedure;reconstruction;Research;Research Personnel;research study;Resolution;Risk;Risk Factors;Risk Reduction;robot control;Robotics;Safety;Schedule;Scheme;screening;seal;soft tissue;Speed;Stroke;Stroke prevention;stroke risk;Study Subject;success;System;Technology;technology development;therapy development;three-dimensional visualization;Thrombus;Time;Transesophageal Echocardiography;Transfusion;Ultrasonography;United States;User-Computer Interface;Validation;Vertebrates;Visualization;Work

PROJECT_TITLE: Magnetic Resonance Imaging Guided Robotic Catheter System for Left Atrial Appendage Occlusion Procedures


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Heart Disease;Hypertension;Infectious Diseases;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARATIVE Hypertension is a major contributor to cardiovascular morbidity and mortality for PWH. There is a critical need to understand drivers of nonadherence to antihypertensive medications to rigorously design, implement, and evaluate interventions to reduce the burden of hypertension in PWH.

PI_NAMEs: MUIRURI, CHARLES  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: acceptability and feasibility;Achievement;Acute myocardial infarction;Address;Adherence;Anti-Hypertensive Agents;antiretroviral therapy;Award;behavior change wheel;Behavioral;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;career development;Caring;Clinic;comorbidity;cost;Data;Decision Making;design;Development Plans;dosage;Dyslipidemias;econometrics;Enrollment;evidence base;Evidence based intervention;Evidence based treatment;experience;Frequencies;Funding;General Population;global health;Goals;Health Sciences;Health Services;Health Services Research;Health system;Healthcare Systems;high risk;HIV;HIV/AIDS;Home Blood Pressure Monitoring;human centered design;Hypertension;hypertension treatment;implementation evaluation;implementation framework;implementation intervention;implementation science;improved;insight;instructor;Intervention;Interview;Medical;medication compliance;medication nonadherence;meetings;Mentored Research Scientist Development Award;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;multi-component intervention;Myocardial Infarction;Nurses;Outcome;patient-level barriers;Patients;Perception;Persons;Pharmaceutical Preparations;Physicians;population health;preference;prevent;primary care provider;Program Development;programs;Provider;provider-level barriers;Qualitative Methods;Research;Research Personnel;Risk;Science;side effect;skills;Structure;Surveys;theories;therapy adherence;therapy design;Time;Training;United States;Universities;Viral;Work;working group

PROJECT_TITLE: Addressing barriers to anti-hypertensive medication adherence among persons living who have achieved viral suppression


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: MADISON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Stem cells maintain the function of many of our organs and are also highly influenced by our metabolism and physiology, and these processes are often altered in obese individuals. We propose to take advantage of powerful research tools in fruitflies to investigate how stem cells and their descendants alter their preference for different types of nutrients, including sugars, fats and amino acids, and how this process is regulated during normal physiology or under obesity conditions. Because of the high degree of evolutionary conservation of molecules and biological processes between fruitflies and humans, this work will likely provide valuable insights into diseases resulting from metabolic abnormalities.

PI_NAMEs: DRUMMOND-BARBOSA, DANIELA  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adipocytes;Affect;Amino Acids;Biological Process;Brain;Carbohydrates;Cell Differentiation process;Cell Lineage;Complex;daughter cell;Development;Diet;dietary;Disease;Drosophila genus;Drosophila melanogaster;Ecdysone;experience;Fatty acid glycerol esters;Fatty Acids;germline stem cells;Hormones;Human;in vivo;insight;insulin-like peptide;Ketone Bodies;Knowledge;Link;lipid transport;Lipids;lipophorin;macromolecule;Malignant Neoplasms;Mediating;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;Metabolism;Modeling;Nutrient;Nutritional Support;obese person;Obesity;Oocytes;Oogenesis;Organ;Organism;Ovary;Pathway interactions;Phosphotransferases;Physiological;Physiology;preference;Process;Research;response;Signal Transduction;Sirolimus;stem cells;steroid hormone;sugar;System;tissue stem cells;tool;Unhealthy Diet;uptake;Work

PROJECT_TITLE: Nutrient fuel preference, obesity, and stem cell lineage physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAMPAIGN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE The actin cytoskeleton is the structural scaffold that gives cells their shape, and actin remodeling is essential to cell function and tissue building. We are interested in the genetic and molecular mechanisms that regulate actin remodeling in both normal and stressful environments (e.g. in the presence of fever or drugs). Our studies will identify vulnerabilities that precipitate failed actin remodeling, providing clues as to the genes and conditions that underlie birth defects and disease.

PI_NAMEs: SOKAC, ANNA  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actin-Binding Protein;Actins;Actomyosin;Back;biological adaptation to stress;Cell Nucleus;Cell Physiology;Cell Shape;Cells;Congenital Abnormality;Contracts;Cytoplasm;Cytoskeleton;Disease;Drosophila genus;Educational process of instructing;Embryo;Embryology;Environment;Event;Failure;Fever;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic Transcription;Goals;Health;Homeostasis;interest;Kinetics;live cell imaging;mechanical properties;Mediator;Messenger RNA;Methods;Microfilaments;Molecular;Morphogenesis;Myosin S-2;Organism;Outcome;Pharmaceutical Preparations;Phase;Phenotype;Process;Proteins;Resolution;Risk;Role;scaffold;Shapes;Signal Transduction;single molecule;stem;Stress;System;Testing;Textbooks;Tissues;Work

PROJECT_TITLE: Actin cytoskeleton from nucleus to organism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Rural Health;Social Determinants of Health

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Findings from observational studies and randomized controlled trials suggest that weight loss, physical activity, and a healthy diet potentially attenuate the negative effects of obesity and reduce cancer risk and mortality. Evidence-based weight loss interventions in clinical settings showed health benefits, but not generalizable to rural and Appalachian populations due to their unique characteristics. This application carefully designed series of specific aims to provide insight on health behaviors and lifestyle interventions in rural and Appalachian populations, and to design and deliver an efficacious weight loss intervention to reduce cancer risk and disparities for this population.

PI_NAMEs: ZHANG, XIAOCHEN  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Adult;Appalachian Region;Area;Attenuated;Behavior Therapy;Behavioral Risk Factor Surveillance System;Biological;Biological Markers;Body Composition;Body Weight;Body Weight decreased;Breast;cancer health disparity;cancer prevention;cancer risk;Characteristics;Cholesterol;Clinical;Colorectal;comorbidity;Control Groups;Counseling;County;Data;design;Diabetes Mellitus;Diet;Dietary intake;disorder risk;Disparity;Disparity population;Dose;Endometrial;evidence base;Evidence based intervention;experience;Faith;Family;Goals;good diet;Health;Health behavior;Health Benefit;health disparity;Health Food;Health Promotion;Healthcare;Heart Diseases;Height;Hypertension;Incidence;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Insulin;Intake;interest;Intervention;intervention effect;Learning;Life Style;Life Style Modification;lifestyle intervention;Liver;Malignant Neoplasms;Mediating;Mediation;Metabolic;Modification;mortality;multidisciplinary;obese person;Obesity;Obesity associated cancer;obesity treatment;Observational Study;Ohio;Outcome;Overweight;Pancreas;Patient Self-Report;Phase;Physical activity;Physiological;Pilot Projects;Population;Population Heterogeneity;Postdoctoral Fellow;Prediabetes syndrome;Premature Mortality;Preventable cancer cause;programs;Randomized;randomized trial;Randomized, Controlled Trials;Recreation;Research;Research Personnel;Research Project Grants;Residencies;Resources;response;Risk;Risk Factors;Role;Rural;Rural Appalachia;rural disparities;Rural Population;rural setting;Self Efficacy;Series;Social support;Techniques;telephone based;Text Messaging;therapy design;therapy development;Training;Translating;Translational Research;Translations;Travel;Underserved Population;urban area;Urban Population;Walking;Weight;weight loss intervention;weight loss program

PROJECT_TITLE: Addressing Obesity to Reduce Cancer Risk and Health Disparities in Underserved Populations


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Sphingolipids from Porphyromonas gingivalis, a key organism in chronic periodontitis which affects up to 42% of adults in the US over the age of 30, are known to limit host inflammation. The proposed work outlined in the training plan for this NRSA Individual Predoctoral Fellowships to Promote Diversity in Health-Related Research (F31) Award will support pre-doctoral candidate Zavier Eure throughout his graduate program at University of Florida. Mr. Eure will investigate the role of microbial sphingolipids on Porphyromonas gingivalis by defining OMV uptake mechanisms and SL-mediated immunomodulation.

PI_NAMEs: EURE, ZAVIER G (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Adult;Affect;Age;Amino Alcohols;Anabolism;Award;Bacteria;base;Biological;Biomedical Research;bone loss;Career Mobility;Cell Line;Cell model;Cells;Chemicals;Chemistry;chronic inflammatory disease;Clinical;Clinical Data;Complex;Data;defined contribution;Deposition;Development;dihydroceramide;Disease;dysbiosis;Elements;experimental study;Fellowship;Florida;Future;Gingiva;Goals;Grant;Head;Health;Homeostasis;Human;Human Cell Line;Immune;immunoregulation;improved;Individual;Infection;Inflammation;inflammatory milieu;Inflammatory Response;inhibitor;innate immune sensing;insight;Investigation;Knowledge;Label;Learning;Link;Lipids;Macrophage;matriculation;Measures;Mediating;Membrane;Methods;Microbe;microbial;microorganism;Microscopy;Monitor;morphogens;Mouth Diseases;Mus;mutant;Myelogenous;National Research Service Awards;Natural Immunity;novel;Oral;oral bacteria;oral biology;Oral cavity;Organism;Outcomes Research;Parents;pathobiont;pathogen;Pathway interactions;Periodontal Diseases;Periodontitis;Phosphorylation;Play;polymicrobial disease;Porphyromonas gingivalis;pre-doctoral;Predisposition;Prevention approach;Process;programs;Prokaryotic Cells;protein degradation;Proteins;Reporter;Research;response;Role;Route;Science;Secondary to;Signal Transduction;skills;Sphingolipids;Stimulus;subgingival microbiota;Techniques;Testing;Tissues;TLR2 gene;Toll-like receptors;Tooth Loss;Tooth structure;Training;Universities;uptake;Vesicle;Western Blotting;Work

PROJECT_TITLE: Defining the role of sphingolipids on Porphyromonas gingivalis outer membrane vesicle uptake and elicited inflammation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cell migration is a ubiquitous process that is critical for human development, wound healing, the immune response, and even pathological conditions such as cancer metastasis. Cell migration is influenced by expression of aquaporins, or water channels, on the cell surface, though the mechanisms by which AQPs regulate cell migration are not well understood. This MIRA proposal’s goal of understanding how AQPs regulate these cell behaviors is especially relevant and fascinating because of AQPs’ location on the cell surface as transmembrane proteins, with potential to regulate many intracellular activities, such as cell volume regulation, intracellular signaling, and cell polarization.

PI_NAMEs: STROKA, KIMBERLY  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;Area;biological systems;Biomechanics;Biomedical Engineering;Blood - brain barrier anatomy;Cell Adhesion;cell behavior;Cell Communication;Cell membrane;Cell model;cell motility;Cell surface;Cell Volumes;Cells;cellular engineering;Computer software;Coupled;Custom;Disease;Drug Delivery Systems;Engineering;fascinate;Funding;Goals;Health;Human Development;image processing;Immune response;in vitro Model;Integral Membrane Protein;Link;live cell imaging;Location;mechanical force;Mechanics;Mediating;microdevice;Microfabrication;migration;Molecular Biology;Molecular Biology Techniques;multi-scale modeling;National Institute of General Medical Sciences;Neoplasm Metastasis;novel;Pathologic;Phenotype;Physiological;polarized cell;Positioning Attribute;Process;programs;Property;quantitative imaging;Regulation;Research;response;Role;Signal Transduction;System;Techniques;tool;Vascular Endothelium;water channel;Work;wound healing

PROJECT_TITLE: Exploring mechanisms of aquaporin-mediated cell migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This training program is dedicated toward increasing the number of well-trained physicians who also perform basic science studies (do research) in head and neck cancer. We seek to reach this goal through providing training in laboratory techniques, research methodology and preparing the trainees for academic careers in head and neck cancer.

PI_NAMEs: ZEVALLOS, JOSE P. (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Head and neck structure;Oncology;post-doctoral training

PROJECT_TITLE: Postdoctoral Training in Head and Neck Oncology

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The interior of many organs, such as the lungs and intestines, is line with an extracellular matrix critical to their function. Issues with this matrix contribute to many human diseases, including chronic obstructive pulmonary disease (COPD), ulcerative colitis, and many forms of cancer. This study will provide insight into how the components of this matrix are produced and coat the proper surfaces.

PI_NAMEs: SCHMIDT, HELEN FRANCES (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Apical;Binding;Biological;Biological Assay;Biology;Biomedical Research;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;career;Cell Nucleus;cell type;Cells;Cellular biology;Chronic Obstructive Pulmonary Disease;Classification;Collagen;Communities;Complex;Confocal Microscopy;Data;design;Destinations;Development;differential expression;Educational process of instructing;EGF gene;Environment;Epithelium;experimental study;extracellular;Extracellular Matrix;Fibronectins;fluorescence imaging;Fluorescent in Situ Hybridization;Future;gene product;gene regulatory network;Gene Structure;Genes;Genetic;Genetic Transcription;genomic platform;Genomics;Glycocalyx;Goals;human disease;inner ear diseases;insight;Institution;Intestines;knock-down;Laboratories;Labyrinth;Lobular Neoplasia;Lung;Malignant Neoplasms;Membrane Proteins;Microscopy;Modeling;Monitor;Mucins;mutant;Nature;notch protein;Organ;Organism;Pattern;Pennsylvania;Peptide Hydrolases;Process;promoter;Protein Family;Proteins;Proteolysis;recruit;Research;Resolution;Resources;RNA Interference;Role;Running;sample fixation;Shapes;Signal Pathway;single cell technology;single nucleus RNA-sequencing;Site;Sorting;Specific qualifier value;Structure;Surface;System;Techniques;Tertiary Protein Structure;Testing;Training;transcription factor;transcriptome;transcriptomics;Tube;Tubular formation;Ulcerative Colitis;undergraduate student;Universities;Vulva;Work;Zona Pellucida

PROJECT_TITLE: Cell-type specific assembly of apical extracellular matrices

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Positron emission tomography (PET) imaging with radiotracers is used in hospitals around the world for several applications, including cancer staging and response to treatment assessment, and also is an important tool in biomedical research for investigating a wide range of health and disorders. The raw data collected by a PET scanner does not immediately produce an image and is instead reconstructed from a series of angular views using a tomographic reconstruction algorithm, but theoretically, the physics does allow for directly producing an image provided the detectors are sufficiently fast to determine the detection time difference of the photons with resolution of less than 25 picoseconds. In this proposal we aim to develop ultra-fast instrumentation and supporting computational algorithms leading to the first demonstration of a reconstruction-free imaging system for cross-sectional imaging of radiotracers.

PI_NAMEs: KWON, SUN IL (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: 3-Dimensional;Algorithms;Anodes;Area;Biomedical Research;breast imaging;Cherenkov Radiation;Clinical;clinical application;clinical imaging;clinical translation;Complement;Computational algorithm;convolutional neural network;Data;Data Collection;deep learning;design;Detection;detection sensitivity;detector;Development;Diagnostic Neoplasm Staging;Discrimination;Disease;Event;Excision;Eye;flexibility;Foundations;Future;Generations;Geometry;Glass;Goals;Health;heart imaging;Hospitals;human imaging;Image;image reconstruction;Imaging Device;imaging platform;imaging system;improved;innovation;instrumentation;Lead;Light;Location;Machine Learning;machine learning algorithm;Measures;Monte Carlo Method;Nature;Noise;novel;Optics;Outcome;Patients;Performance;personalized care;photomultiplier;Photons;Physics;portability;Positioning Attribute;Positron;Positron-Emission Tomography;preservation;process improvement;Property;prototype;Radiation Dose Unit;Radioisotopes;radiotracer;Reaction Time;real-time images;reconstruction;Refractive Indices;Resolution;response;Sampling;scale up;Scanning;Series;signal processing;Signal Transduction;simulation;System;Techniques;Technology;Three-Dimensional Image;Three-Dimensional Imaging;Time;tomography;tool;Translations;treatment response;Tube;Vision;Work

PROJECT_TITLE: Reconstruction-free three dimensional positron emission imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE  Several strategies or contexts help patients with Parkinson’s disease to move more quickly or normally, however the brain mechanisms underlying these phenomena are poorly understood. The proposed studies employ multiple complimentary electrophysiology and neuroimaging techniques to understand the brain mechanisms supporting improved movements. The identified biomarkers may provide targets for future neuromodulation therapies to improve symptoms that are refractory to current treatments, such as freezing of gait.

PI_NAMEs: CROSS, KATHRYN AMY (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Affect;Age;Auditory;auditory stimulus;Basal Ganglia;behavior measurement;behavior prediction;Behavioral;Biological Markers;biomarker identification;Brain;career development;clinical movement disorder;cognitive neuroscience;Communities;Complication;Cues;Data;Deep Brain Stimulation;deep brain stimulator;density;Development;Development Plans;Diffusion;Disabling;Disease;Dissociation;Dorsal;Electrocorticogram;Electroencephalography;Electrophysiology (science);Environment;Failure;falls;forging;Freezing;Functional Magnetic Resonance Imaging;Future;Gait;Globus Pallidus;Goals;Heterogeneity;Image;implantation;improved;Incentives;Independent Living;Individual Differences;Injury;insight;kinematics;Kinesis;Magnetic Resonance Imaging;Maps;Measures;Mediating;Mentorship;Methods;Modality;Motivation;Motor;motor deficit;motor disorder;Motor output;motor symptom;Movement;neural network;Neuroanatomy;neuroimaging;neuromechanism;neurophysiology;neuroregulation;neurotransmission;novel;novel therapeutics;Operative Surgical Procedures;Parietal;Parkinson Disease;Participant;Pathologic;Patients;Periodicity;Physicians;Physiology;Quality of life;Refractory;rehabilitation strategy;Research;response;Rest;Rewards;Scientist;Sensory;Severity of illness;Signal Transduction;skills;statistics;Stimulus;STN stimulation;symptomatic improvement;Symptoms;System;Techniques;Testing;therapy development;time interval;tractography;Training;Transcranial magnetic stimulation;Ventral Striatum;Visual;visual motor;Work

PROJECT_TITLE: Neurophysiological Biomarkers of Movement Facilitation in Parkinson’s Disease

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: Narrative (Overall)  This is an Ovarian Cancer SPORE resubmission (A1) application, submitted by a team of investigators from the Dana-Farber/Harvard Cancer Center (DF/HCC). The SPORE contains three projects and four cores, which are highly interactive. It also contains a Developmental Research Program (DRP) and a Career Enhancement Program (CEP). The program is focused on the broadest and most urgent questions in ovarian cancer therapy, including novel drug combinations, and immunotherapy.

PI_NAMEs: CASTRO, CESAR M;D'ANDREA, ALAN D. (contact);MATULONIS, URSULA ANNE

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Address;Advocate;anti-cancer research;Antigen Targeting;Area;Basic Science;BCL1 Oncogene;Biological;Biological Markers;Biological Models;Biometry;Cancer Center;Cancer Patient;cancer therapy;Cancer Vaccines;career;Clinical;clinical development;Clinical Trials;Clinical Trials Design;Collaborations;Companions;Correlative Study;Dana-Farber Cancer Institute;Decision Making;Dedications;design;Development;DNA Repair;Drug Combinations;drug development;drug sensitivity;efficacy evaluation;experience;extracellular;Funding;General Hospitals;Generations;Goals;Grant;Gynecologic Oncology;Hospitals;Human;immune checkpoint blockade;Immunotherapy;improved;improved outcome;In Vitro;inhibitor;innovation;Institution;International;Investigation;Israel;Laboratories;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Massachusetts;Mediating;medical schools;MEKs;member;Mucinous;Mutation;neoantigens;Newly Diagnosed;novel;novel drug combination;novel vaccines;Occupational activity of managing finances;oncology program;Organoids;Ovarian Carcinoma;Pathology;Patient-Focused Outcomes;Patients;Poly(ADP-ribose) Polymerase Inhibitor;predictive marker;Principal Investigator;programs;Recurrence;Refractory Disease;Relapse;Research;Research Personnel;Resistance;resistance mechanism;response;Role;Scientist;senior faculty;Serous;Solid Neoplasm;Specialized Program of Research Excellence;Structure;Technology;Therapeutic;translational progress;tumor;tumor progression;vaccine trial;women's outcomes;Writing

PROJECT_TITLE: Dana Farber/Harvard Cancer Center Ovarian Cancer SPORE grant


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE – Administrative Core The overarching goals of the Administrative Core of this Dana-Farber/Harvard Cancer Center (DF/HCC) Ovarian Cancer SPORE application are to provide leadership and administrative oversight of the overall SPORE grant, integration of the SPORE components and the overall Ovarian Cancer SPORE within the Dana- Farber/Harvard Cancer Center (DF/HCC), and promote and engage activities that allow the success of the Ovarian Cancer SPORE Projects, Cores, the Developmental Research Program (DRP) and the Career Enhancement Program (CEP).

PI_NAMEs: D'ANDREA, ALAN D. (contact)

PROJECT_TITLE: Core A: Administrative Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cardiovascular;Congenital Heart Disease;Heart Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases

ORG_CITY: BROOKLYN

ORG_NAME: NARROWS INSTITUTE FOR BIOMEDICAL RES INC

PHR: PROJECT NARRATIVE Patients with autoimmune diseases or even healthy individuals can present with pathogenic antibodies called anti-Ro antibodies, and these antibodies can increase the risk for cardiac abnormal heart rhythm and may cause sudden cardiac death. In this research, we propose to develop decoy molecules that will distract and neutralize these pathogenic antibodies and prevent cardiac arrhythmia. We will use an animal model for autoimmune disease to test our decoy peptides and study the mechanism of anti-Ro elicited cardiac arrhythmia, anticipating that we can translate our findings to preclinical and hopefully clinical testing in the near future.

PI_NAMEs: BOUTJDIR, MOHAMED  (contact);CARDOZO, TIMOTHY J

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acceleration;Action Potentials;Affinity;Amino Acid Sequence;Animal Model;Antibodies;Antigens;Arrhythmia;Attention;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmunity;B-Lymphocyte Epitopes;Binding Sites;Biological;Cardiac;Cardiac Myocytes;Cavia;Classification;Clinical;Cross Reactions;cross reactivity;Data;design;Developed Countries;Development;Diagnosis;Disease;drug candidate;Electrocardiogram;Electrophysiology (science);Enhancers;Enzyme-Linked Immunosorbent Assay;Epitopes;Ethers;Event;extracellular;Future;General Population;Genes;Genetic;Heart Abnormalities;heart rhythm;High Prevalence;Human;Immunization;Immunize;Immunoglobulin G;in vivo;Incidence;Individual;inhibiting antibody;innovation;Ion Channel;Ions;Licensing;Life;Long QT Syndrome;Mediating;Membrane Proteins;Molecular;molecular modeling;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;mutation screening;novel;novel strategies;novel therapeutics;Nuclear;Pathogenesis;Pathogenicity;Patients;peptide drug;Peptides;peptidomimetics;Pharmaceutical Preparations;Population;Positioning Attribute;Potassium Channel;pre-clinical;prevent;Public Health;rational design;Recording of previous events;Research;research clinical testing;Risk;Risk Factors;SS-A antibodies;SS-A antigen;sudden cardiac death;Surface;Technology;Testing;Therapeutic;three dimensional structure;three-dimensional visualization;time interval;tool;Torsades de Pointes;Translating;Translations;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Rescue of Autoimmune-Associated Long QT Syndrome by Decoy Peptides

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Despite dramatic improvements in breast cancer (BC) prognosis over the past two decades, major survival differences after diagnosis persist, even within similar stage and molecular BC subtypes. This proposal aims to use what we know about risk of developing breast cancer, including genetics and clinical factors, to improve prediction of outcomes following a BC diagnosis and improve BC survivorship.

PI_NAMEs: ZEINOMAR, NUR  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Accounting;Address;Advisory Committees;Affect;African ancestry;African Women;Australia;Black race;black women;Breast;breast cancer diagnosis;breast cancer family registry;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer survivor;Breast Cancer survivorship;Canada;cancer diagnosis;Cancer Prognosis;cancer recurrence;cancer subtypes;cancer therapy;career development;Characteristics;Clinical;clinical care;clinical implementation;Clinical Markers;clinical translation;cohort;Contralateral Breast;Data;Death Rate;Development;Development Plans;Diagnosis;Educational workshop;Enrollment;Epidemiology;Estrogen receptor negative;Ethnic Population;European ancestry;Event;experience;Family;Family history of;follow-up;Follow-Up Studies;Future;Gene Expression Profiling;Genetic;genetic association;genetic pedigree;Genetic Variation;genome-wide;Genomics;Genotype;Germ Lines;Goals;Health;health disparity;Heritability;high risk;high risk population;Hormone Receptor;improved;improved outcome;individualized prevention;Inherited;International;Intervention;Interview;K22 Award;Knowledge;knowledge translation;Learning Skill;Linkage Disequilibrium;Longitudinal Studies;Lymph Node Involvement;lymph nodes;Malignant Breast Neoplasm;meetings;Modeling;Molecular;mortality;mortality risk;neoplasm registry;New Jersey;novel;novel strategies;oncotype;Outcome;outcome prediction;Performance;Persons;polygenic risk score;population based;precision medicine;predictive modeling;Prognosis;prognostic index;prognostic tool;Public Health;Race;racial population;Recommendation;recruit;Research;Research Personnel;Resources;Risk;Risk Assessment;risk prediction;Risk Reduction;risk stratification;RNA;screening guidelines;skills;Socioeconomic Status;Subgroup;survival prediction;symposium;tertiary prevention;Training;Translating;Translations;tumor;United States;Variant;Woman

PROJECT_TITLE: Leveraging high-risk populations for precision prevention: A novel approach for improving risk prediction for outcomes after a breast cancer diagnosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE  The research proposed in this ovarian cancer SPORE application requires various forms of fresh human tumor  and normal tissue that has been properly collected and uniformly processed. This centralized pathology core  will work with each project and other core to ensure that appropriate human tumor tissue is collected and  allocated for all proposed research and also deposited in the appropriate tissue banks for later research. In  addition, core pathologists will work with each project to provide expert pathologic interpretation of all human  tissue studies, overall allowing for generation of the most accurate data and experimental interpretation and  maximizing the research that is done from these valuable human samples.

PI_NAMEs: KOLIN, DAVID  (contact)

PROJECT_TERMS: Address;Antibodies;Archives;Attention;Award;Biological Markers;Biological Models;Biostatistics Core;Blood;Cancer Center;Case Study;Clinical Research;Clinical Trials;Collaborations;Consent;Dana-Farber Cancer Institute;Data;Data Analyses;Deposition;design;Destinations;Eligibility Determination;Ensure;experience;Experimental Designs;experimental study;Freezing;Fresh Tissue;Frozen Sections;Generations;Glean;Goals;Grant;Guidelines;Human;Human Resources;human tissue;Immune response;Immunofluorescence Immunologic;Immunophenotyping;Individual;innovation;insight;Institution;Institutional Review Boards;Laboratories;Life;Malignant neoplasm of ovary;Mission;model organism;Monitor;Morphology;Normal tissue morphology;novel therapeutics;operation;Organoids;Outcome;Ovarian;Ovarian Serous Adenocarcinoma;Paraffin Embedding;Participant;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patient-Focused Outcomes;Patients;Procedures;Process;Protocols documentation;quality assurance;Quality Control;repository;Reproduction spores;Research;Research Activity;Research Personnel;Retrieval;Sampling;Schedule;Services;Site;Standardization;Strategic vision;Tissue Banks;tissue fixing;Tissue Sample;Tissue Stains;Tissues;treatment response;Triage;Tumor Tissue;Update;vaccine trial;Vaccines;Visual;Woman;Work

PROJECT_TITLE: Pathology Core


PHR: Project Narrative The Biostatistics Core will provide statistical and computational consultation and in depth collaboration to the ovarian cancer SPORE research program in the areas of planning, design, conduct, analysis, and reporting of laboratory experiments, and clinical trials. In addition, the biostatistics core will help train SPORE personnel in data forms design, data management, and data quality control.

PI_NAMEs: SKATES, STEVEN J (contact)

PROJECT_TERMS: Address;Animals;anti-cancer research;Area;Biological Markers;Biological Models;Biometry;Biostatistics Core;Cancer Center;career;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Computer software;Consultations;Correlative Study;Dana-Farber Cancer Institute;Data;Data Analyses;Data Collection;data management;data quality;Data Science;Databases;design;Development;Ensure;Evaluation;Experimental Designs;General Hospitals;Grant;Human Resources;interest;Laboratories;laboratory experiment;Malignant neoplasm of ovary;Malignant Neoplasms;Massachusetts;member;Methodology;Methods;mid-career faculty;Mission;Monitor;Organoids;Outcome;Ovarian;Pathology;preclinical study;Process;programs;quality assurance;Quality Control;Reporting;Research;Research Personnel;Role;Skates;Statistical Methods;statistics;Training;Translational Research;Work

PROJECT_TITLE: Biostatistics Core


PHR: Narrative This is a competing continuation to support six post-doctoral positions to provide rigorous research training for pulmonary physicians at the fellowship level and Ph.D. recipients with interests in lung disease. The ultimate goal is to develop pulmonary scientists in either basic or clinical research who can successfully continue their careers in academics or the biomedical industry. Trainees can focus on basic or translational training.

PI_NAMEs: MEYER, NUALA JENNINGS (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Immunology;Lung;Training

PROJECT_TITLE: TRAINING IN PULMONARY IMMUNOLOGY

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: NARRATIVE - Core 3: Organoid, Model Systems, and Biomarkers Core  The overarching goals of the Organoids, Model Systems, and Biomarkers Core are to provide tissue collection infrastructure, murine PDX models, and HGSC organoid models for combination drug testing and biomarker analysis. The core will be utilized by all three projects of the Dana-Farber/Harvard Cancer Center Ovarian Cancer SPORE program.

PROJECT_TERMS: Apoptosis;Architecture;Biological Assay;Biological Markers;Biological Models;Biopsy;Cancer cell line;Cancer Center;cancer therapy;Cell Culture Techniques;Cell Line;Cells;chemotherapy;Clinical;Clinical Trials;Collection;design;Development;DNA Repair;Drug Combinations;Drug Evaluation;Drug resistance;drug sensitivity;drug testing;Environment;functional loss;functional status;Generations;Genes;Goals;Grant;Guidelines;Gynecologic Oncology Group;In Vitro;in vivo;Infrastructure;infrastructure development;inhibitor;insight;Investigation;ITGB2 gene;Laboratories;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;Modeling;mouse model;Mus;Mutation;neoplastic cell;Newly Diagnosed Disease;novel strategies;Organoids;Ovarian;Paracentesis;Participant;patient derived xenograft model;Patients;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Primary Cell Cultures;programs;Protocols documentation;Publications;Recurrent disease;repository;Reproducibility;Research;Research Personnel;Residual Neoplasm;Resistance;Resistance development;response;restoration;sample collection;Sampling;Serous;Services;Therapeutic procedure;therapeutic target;therapy resistant;Thoracentesis;Tissue Banks;treatment response;tumor;tumorigenic;Validation;Work;Xenograft Model

PROJECT_TITLE: Organoid, Mouse Model, and Biomarker


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Women's Health Research

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative: The only effective means of breast cancer prevention in women with inherited BRCA mutations is prophylactic mastectomy, which, while effective, raises issues relating to quality of life and other psychological and physical consequences. The overarching objective of this application is to develop strategies to detect and eliminate pre-malignant cells in breast tissues from high-risk women. To accomplish this goal, we have used state-of- the-art single-cell technologies to detect and isolate subpopulations of breast cells that accumulate in BRCA1 and BRCA2 mutation carriers and propose studies to determine how these subpopulations contribute to tumor development and what causes their accumulation in order to develop strategies to interfere with cancer development in high-risk women.

PI_NAMEs: BRUGGE, JOAN SIEFERT (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: brca gene;BRCA mutations;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast;Breast Cancer Prevention;Breast Cancer Risk Factor;Cell Lineage;Cell Proliferation;Cells;Cytometry;Development;diagnostic strategy;DNA Damage;Evolution;Goals;high risk;high risk population;High Risk Woman;High-Risk Cancer;Histology;Human;Image;Immunocompromised Host;Immunofluorescence Immunologic;In Situ;Inherited;Intervention;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Masks;Mus;mutant;Mutation;mutation carrier;novel diagnostics;Organoids;Periodicity;Population;Population Analysis;premalignant;Premalignant Cell;Premalignant Change;prevent;programs;Proliferation Marker;prophylactic;prophylactic mastectomy;psychologic;Quality of life;reconstitution;RNA;single cell analysis;single cell technology;single-cell RNA sequencing;Structure;Surface;Susceptibility Gene;Technology;Tissues;tool;tumor;tumor progression;tumorigenesis;Woman;women's prevention

PROJECT_TITLE: Tracking the evolution of breast cancer through single cell analyses of premalignant breast tissues from women at high risk for cancer development


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE PARP inhibitors comprise the most important new drug class introduced into ovarian cancer practice in the last 25 years. This project will investigate ATR inhibition in preclinical models and in clinical trials as a strategy to reverse mechanisms of acquired resistance and to address those cancers under replication stress that are intrinsically PARP inhibitor-resistant. The work should provide new drug-based approaches designed to improve ovarian cancer outcomes.

PI_NAMEs: SHAPIRO, GEOFFREY I (contact)

PROJECT_TERMS: Address;ATR gene;Biological Assay;Biological Markers;Biology;biomarker development;biomarker signature;Biopsy;Biopsy Specimen;BRCA mutations;BRCA1 gene;BRCA2 gene;cancer cell;Cancer cell line;Cancer Center;Cancer Patient;candidate marker;CCNE1 gene;Cell Line;CHEK1 gene;Clinical;Clinical Data;Clinical Trials;cohort;course introduction;Cytology;Cytotoxic Chemotherapy;Data;Defect;design;Development;Disease;DNA fiber assay;DNA Repair Pathway;DNA replication fork;gemcitabine;Gene Expression Profile;Grant;homologous recombination;homologous recombination deficiency;improved;In Vitro;in vivo;inhibitor;insight;liquid biopsy;Maintenance;Malignant neoplasm of ovary;Malignant Neoplasms;Maximum Tolerated Dose;Mediating;Modeling;Mutate;novel;novel drug class;novel therapeutics;Nuclear;nucleoside analog;Organoids;Outcome;Ovarian;p53-binding protein 1;Pathway interactions;patient derived xenograft model;Patients;Pharmacodynamics;Phase I Clinical Trials;Phosphorylation;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Population;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Prognosis;randomized trial;recombinational repair;Refractory;replication stress;Resistance;response biomarker;restoration;Role;Schedule;Serous;Stress;Testing;Translating;Translations;Treatment Protocols;tumor;tumor progression;Work

PROJECT_TITLE: ATR inhibitor-mediated reversal of PARP inhibitor resistance in high-grade serous ovarian cancer (HGSOS)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Behavioral experiments in humans and primates show that novel visual objects motivate behavior by capturing attention and gaze, and promoting the formation of new memories. Abnormalities in novelty seeking are associated with anxiety, depression, anhedonia and autism, but despite the importance of novel objects in our daily life, and the clinical relevance of novelty seeking, we lack an understanding of how primate brain circuits control novelty related behaviors. Our experiments will reveal the neuronal mechanisms of novelty seeking in non-human primates – a fundamental form of motivation that is uniquely dysregulated in many disorders of cognition and mood.

PI_NAMEs: MONOSOV, ILYA E. (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TITLE: Neuronal mechanisms of novelty seeking

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Data Science;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Understanding the interaction between the foods we eat, metabolism by our microbiome, and the downstream effect on our bodies is key to deepening our understanding of nutrition. However, the scientific community lacks a centralized resource to collectively aggregate discoveries, hindering the ability to build on others' works. By building a knowledge base together with the needs of the community, we aim to aggregate, propagate, and apply this community knowledge that will serve to accelerate new discoveries.

PI_NAMEs: DORRESTEIN, PIETER C (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: absorption;Acceleration;Address;Archaea;Bacteria;Bacteriophages;Beverages;Biological;Biological Assay;Characteristics;Collaborations;Communication;Communities;Community Outreach;Data;data ecosystem;data repository;data sharing;data submission;data visualization;Deposition;Development;Diet;Digestion;Documentation;Eating;Ecosystem;Educational workshop;Ensure;experience;FAIR principles;Food;fungus;Gene Cluster;genetic element;Goals;Health;Hour;Human;human microbiota;improved;Individual;Information Resources;Infrastructure;Inhalation;innovation;Internet;interoperability;Knowledge;knowledge base;knowledge hub;Knowledge Management Center;knowledgebase;Link;Mass Spectrum Analysis;meetings;Metabolism;metabolomics;Metadata;Microbe;microbial;microbiome;microbiome analysis;Molecular;Molecular Structure;National Institute of Diabetes and Digestive and Kidney Diseases;Natural Products;nutrition;Organ;Participant;Pharmaceutical Preparations;Phenotype;Plasticizers;pollutant;precision medicine;Process;Proteins;Research;Research Personnel;resilience;Resources;Skin;small molecule;social;Source;Structure;tool;tool development;Training;training opportunity;web interface;web portal;Work;Xenobiotics

PROJECT_TITLE: Collaborative Microbial Metabolite Center


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunization;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Vaccine Related;Women's Health Research

PHR: Project Narrative Checkpoint blockade monotherapy exhibits only modest activity against ovarian cancer. Building on our ability to identify cancer determinants that can be recognized by the immune system (so-called ‘antigens’) from patient tumors, including from ovarian cancer, that are optimal because they are expressed only on tumor cells (and not normal cells) and are highly immunostimulatory, and based on promising data supporting new cancer vaccination efforts to target these personal tumor antigens that may synergize effectively with checkpoint blockade therapy, this proposal aims to investigate the therapeutic potential and biologic activity of this novel immunotherapy strategy for ovarian cancer.

PI_NAMEs: KONSTANTINOPOULOS, PANAGIOTIS  (contact)

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Agonist;anti-PD1 therapy;Antigen Targeting;antigen-specific T cells;Antigens;Autoimmune;Autologous;Autologous Tumor Cell;Binding;Biological;Biological Markers;Biological Models;Biological Testing;Biometry;Biopsy;Blood;Blood specimen;Cancer Center;cancer therapy;cancer vaccination;Cancer Vaccines;Cells;central tolerance;chemotherapy;Clinical;Clinical Trials;Combined Vaccines;computerized tools;Data;design;Development;Disease;Disease Progression;Disease remission;Effectiveness;Epithelial ovarian cancer;Epitopes;Event;Evolution;Exhibits;exome sequencing;Feasibility Studies;Funding;Genetic;genetic evolution;Genomics;Glioblastoma;Grant;Human;Immune;immune cell infiltrate;immune checkpoint blockade;Immune response;Immune system;Immunity;Immunize;immunogenic;Immunoglobulins;Immunologic Adjuvants;Immunologics;Immunotherapy;improved;In complete remission;In Situ;insight;Institutional Review Boards;Malignant neoplasm of ovary;Malignant Neoplasms;Melanoma;Monoclonal Antibodies;mouse model;Mutate;Mutation;Nature;Neoadjuvant Therapy;neoantigen vaccine;neoantigens;neoplastic cell;Newly Diagnosed;Nivolumab;novel;Organoids;ovarian neoplasm;Pathology;Pathway interactions;Patients;Peptides;phase 1 study;Platinum;Poly ICLC;prediction algorithm;pressure;programmed cell death protein 1;prospective test;Proteins;Protocols documentation;Recurrence;Residual Neoplasm;Residual state;Residual volume;response;Safety;safety and feasibility;side effect;Site;Somatic Mutation;Specimen;standard of care;synergism;T cell response;T-Cell Immunologic Specificity;T-Lymphocyte;Testing;Therapeutic;Time;TLR3 gene;Toxic effect;transcriptome;transcriptome sequencing;tumor;Tumor Antigens;Tumor Immunity;Tumor-infiltrating immune cells;vaccine evaluation;Vaccines

PROJECT_TITLE: Project 2: Combined personal neoantigen-targeting cancer vaccines with immune checkpoint blockade for ovarian cancer


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Thrombosis is the leading cause of mortality among patients with JAKV617F+ myeloproliferative neoplasms (MPNs). Although JAKV617F+ endothelial cells are activated in MPN, treatments do not target the vasculature. Using endothelialized microfluidics models to assess endothelial function, we will determine whether reducing JAKV617F+-mediated signaling using JAK-STAT and Gas6-Axl-MERTK inhibitors decreases thrombosis in MPN and thereby establish a mechanistic rationale for novel antithrombotic therapies in MPN.

PI_NAMEs: BECKMAN, JOAN DENISE (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Adhesions;Adhesives;Aftercare;Animal Model;Aspirin;Autocrine Communication;Automobile Driving;Binding;Biological Assay;Blood;Blood Cells;Blood Platelets;Cardiac;Cell Separation;Cells;Cessation of life;Data;Devices;Disease;E-Selectin;Endothelial Cells;Endothelium;Engineering;Environment;Erythrocytes;Event;Exhibits;experience;Family;Flow Cytometry;Future;Genes;Genetic Transcription;Goals;Growth;Hematopoietic;Hematopoietic stem cells;Hemorrhage;Hemostatic function;high risk;Homologous Protein;hydroxyurea;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;Inflammatory;inhibitor;Intercellular adhesion molecule 1;Interferon alpha;JAK1 gene;Janus kinase;Lead;Leukocyte Rolling;Leukocytes;Mediating;MERTK gene;Microfluidic Microchips;Microfluidics;microsystems;Modeling;monocyte;Mononuclear;mortality;mouse model;Mus;Mutation;Myeloproliferative disease;novel;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Physiological;Plasma;Platelet Activation;prevent;Prevention strategy;Production;Protein S;Proteins;receptor;Research;response;Risk;Role;Secondary to;shear stress;Signal Pathway;Signal Transduction;Spleen;STAT3 gene;Stretching;targeted treatment;Techniques;Testing;Therapeutic;Thromboplastin;Thrombosis;thrombotic;TNF gene;Training;Transcription Coactivator;transcriptome sequencing;Vascular Cell Adhesion Molecule-1;Vascular Endothelial Cell;Vascular Endothelium;Venous;Venous blood sampling;venous thromboembolism;von Willebrand Factor;Western Blotting;Whole Blood;Work

PROJECT_TITLE: Engineered microsystems to assess endothelial contribution to myeloproliferative neoplasm thrombosis

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project 3 Project Narrative: Based on evidence that the RAS-ERK pathway is activated in a large percentage of ovarian cancers and evidence of efficacy of combined MEK- BCL-2/XL inhibition in (1) preclinical PDX models of chemoresistant high grade serous ovarian cancer (HGSC), (2) preclinical studies showing efficacy of combined MEK and BCL- 2/XL inhibition in Ras mutant tumors, and (3) a Phase 1 clinical trial showing safety and tolerability of combined treatment with trametinib (MEK inhibitor) and navitoclax (BCL-2/XL inhibitor), we hypothesize that combination MEK and BCL- 2/XL inhibition will have activity in refractory/relapsed ovarian cancer. To test this hypothesis, we will carry out a phase II clinical trial to test the efficacy of combined treatment with trametinib and navitoclax in recurrent platinum-resistant and refractory ovarian cancers harboring alterations in Ras and Raf pathway genes along with HGSC and low grade serous RAS wild type cancers . An active and ongoing study, Dana- Farber/Harvard Cancer Center (DF/HCC) Protocol 13-505 (CTEP 9525 supported by U01CA062490, NCT02079740) is a phase 1 study that has tested the combination of the oral MEK inhibitor trametinib with the oral BCL-2 XL inhibitor navitoclax. The public health impact of this project includes the development of new therapeutic options for patients with hard to treat recurrent ovarian cancer.

PI_NAMEs: MATULONIS, URSULA ANNE (contact)

PROJECT_TERMS: Aftercare;Apoptotic;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;BCL2L11 gene;BIM Bcl-2-binding protein;Biopsy;Cancer Center;cancer subtypes;Cancer Therapy Evaluation Program;cancer type;Carcinoma;Cells;Chemoresistance;chemotherapy;Clinical;clinical efficacy;Clinical Trials;Combined Modality Therapy;Data;Development;Diagnosis;DNA Damage;DNA Sequence Alteration;Dose;Drug Combinations;efficacy evaluation;efficacy testing;enzyme activity;Epithelial ovarian cancer;Exposure to;Fibroblasts;Genes;Genetic;Genomics;Grant;Histologic;Histology;Human;imaging approach;Immune;in situ imaging;inhibitor;Knowledge;Malignant neoplasm of ovary;Malignant Neoplasms;MAP3K1 gene;Measures;MEK inhibition;MEKs;Metabolic;Modeling;Molecular;Mucinous;mutant;Mutate;Mutation Analysis;novel therapeutic intervention;novel therapeutics;Oral;Organoids;Ovarian Carcinoma;ovarian neoplasm;participant enrollment;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;Phase I Clinical Trials;Phase II Clinical Trials;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Polymerase;pre-clinical;Pre-Clinical Model;preclinical study;Progression-Free Survivals;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Protocols documentation;Public Health;Ras/Raf;Recommendation;Recurrence;Refractory;refractory cancer;Relapse;Research;Resistance;response;Safety;Sampling;Schedule;Serine;Serous;Signal Pathway;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;treatment duration;treatment response;tumor;Tumor Cell Line;tumor microenvironment

PROJECT_TITLE: Evaluation of the Efficacy of Trametinib + Navitoclax in recurrent ovarian carcinoma


PHR: PROJECT NARRATIVE – DEVELOPMENTAL RESEARCH PROGRAM The goals of the Developmental Research Program (DRP) are to successfully identify, fund, monitor, and support high risk/high potential pilot projects that take maximum advantage of new research opportunities within the Dana-Farber/Harvard Cancer Center Ovarian Cancer SPORE and to maintain this Program throughout the entire grant term. The success of this Ovarian Cancer SPORE DRP will be dependent upon our ability to engage researchers within and outside of the DF/HCC community who can contribute novel ideas to the diagnosis and treatment of ovarian cancer. Priority will be based upon the novelty of the proposals, evidence to support that the project can be completed within specified timelines and budget proposal, and a proven track record of accomplishment and productivity by the investigator; those projects that have demonstrated great progress and translational research potential will have the potential to become full SPORE Projects but only with the approval of the DF/HCC Ovarian Cancer DRP Executive Committee.

PROJECT_TERMS: Advocate;Attention;Award;Budgets;Cancer Center;community center;Complement;Decision Making;Development;Diagnosis;Early Diagnosis;Ensure;Equilibrium;Evaluation;Faculty;Fostering;Funding;Goals;Grant;high risk;innovation;Institution;Malignant neoplasm of ovary;Mentors;Mentorship;Methods;Minority;Mission;Monitor;novel;Pilot Projects;Prevention;Process;Productivity;Program Research Project Grants;programs;Progress Reports;Reproduction spores;Request for Applications;Research;Research Activity;research and development;Research Personnel;Resistance;Resources;sound;Specific qualifier value;success;synergism;timeline;translational potential;Translational Research;Woman

PROJECT_TITLE: Developmental Research Program (DRP)


NIH_SPENDING_CATS: Genetics

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE The proposed research program will utilize genetic and biophysical approaches to elucidate the organelle- specific roles of membrane lipid components relevant to human health. In the first thrust, the ability of unsaturated lipids to act as viscous and mechanical regulators of mitochondrial respiration will be tested. In the second, the mechanisms by which non-canonical sphingolipids dysregulate endomembrane structure and function will be determined.

PI_NAMEs: BUDIN, ITAY  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Adult;Applied Genetics;biophysical model;biophysical techniques;Blindness;cell behavior;Cell Line;Cell membrane;Cell Physiology;Cells;Chemicals;Development;Diffusion;Disease;Electron Transport;Engineering;Genetic;genetic approach;Genetic Diseases;Goals;Health;Human;Image;imaging approach;Inner mitochondrial membrane;Knowledge;Laboratories;Link;Lipids;Mammalian Cell;Mechanics;Membrane;Membrane Biology;Membrane Lipids;membrane model;Metabolic Diseases;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;Organelles;Phospholipids;programs;Research;Respiration;respiratory;Role;saturated fat;serine palmitoyltransferase;Sphingolipids;Structure;Structure of retinal pigment epithelium;System;Testing;Tissues;tool;Unsaturated Fats;Viscosity;Yeasts

PROJECT_TITLE: Lipidic drivers of organelle function and dysregulation


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Project Narrative  CAREER ENHANCEMENT PROGRAM  The overall goal of the Career Enhancement program (CEP) will be to increase the breadth and  depth of the ovarian cancer translational investigator pool at the DF/HCC and across the US.  We expect to train individuals who will become 2025’s National / International leaders in the  pathobiology, diagnosis, treatment and control of Ovarian Cancers.  The CEP will enhance the impact of the SPORE on the public health of the US population in  four principal ways: 1) The CEP will select and train new ovarian cancer investigators for  translational research; 2) Every candidate selected will be prioritized to require clear  translational impact of their work which can be translated to patients within ovarian cancer within  a 5 year period; 3) the CEP will prioritize gender and ethnic diversity during the selection  process to enhance the breadth of investigators serving the US population in all its diversity; 4)  the CEP is commented to long term mentoring and career development to deliver new faculty  through the early faculty stage and allow them to establish themselves as mature, independent  investigators.

PI_NAMEs: CASTRO, CESAR M (contact)

PROJECT_TERMS: Achievement;American Association of Cancer Research;anti-cancer research;Attention;Cancer Center;cancer therapy;candidate selection;career;career development;Career Mobility;Clinical;Collaborations;Consultations;Dana-Farber Cancer Institute;Dedications;Diagnosis;drug development;Educational process of instructing;Environment;ethnic diversity;Extramural Activities;Faculty;faculty support;Fostering;Funding;Gender;gender diversity;Goals;Grant;Gynecologic Oncology;Hospitals;Individual;Institution;instructor;International;Israel;Leadership;Malignant neoplasm of ovary;Measures;Medical center;medical schools;member;Mentors;Minority Recruitment;Monitor;New England;novel therapeutics;Oncology;Outcome;Outcome Measure;Paper;Patients;Peer Review;Persons;Population;Process;professor;programs;Public Health;Publications;Published Comment;rapid growth;recruit;Research Personnel;Resources;Secure;senior faculty;Societies;Source;success;Supervision;Talents;Training;Training Programs;Translating;translational cancer research;translational impact;Translational Research;translational scientist;Work

PROJECT_TITLE: Career Enhancement Program (CEP)


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE The immune system protects lungs during infections but sometimes an excessive and unchecked immune response can destroy the lungs, resulting in acute lung injury (ALI) or its more severe form referred to as acute respiratory distress syndrome (ARDS). Macrophages are immune cells which can either enhance inflammation or instead dampen inflammation and bring about the repair the lung, depending on the type of macrophage. The proposed research program is focused on harnessing the plasticity of macrophages to increase their repair function and thereby set the foundations for future treatments to prevent lung damage during infections.

PI_NAMEs: MEHTA, DOLLY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: acute care;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Admission activity;Alveolar;Anti-Inflammatory Agents;Automobile Driving;beta catenin;Biology;Bone Marrow;Cell Line;Cells;Characteristics;Clinical;Collaborations;COVID-19 pandemic;CREB1 gene;Critical Illness;cytokine;Death Rate;Development;Disease;Endothelial Cells;Endothelium;Environment;Epithelium;Equilibrium;Face;Foundations;Functional disorder;Future;Generations;Genetic;Genetic Transcription;Genomics;Homeostasis;Host Defense;Image;Immune;Immune response;Immune system;Infection;Inflammation;Inflammatory;Injury;innovation;insight;Instruction;Intensive Care Units;interstitial;Intervention;intravital imaging;Ion Channel;Lung;lung injury;lung repair;Macrophage;Maps;Measures;Mediating;Microbe;migration;monocyte;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;optogenetics;pathogen;Patients;Phagocytosis;Phenotype;Population;postnatal;Potassium;prevent;Process;programs;Pulmonary Inflammation;Purinoceptor;recruit;repair function;repaired;Reporter;Research;Resolution;Role;Sampling;Sentinel;Signal Pathway;Signal Transduction;Structure of parenchyma of lung;success;Supportive care;synthetic biology;Testing;Therapeutic;tissue repair;Tissues;tool;transcription factor;transcriptomics;ultra high resolution;WNT Signaling Pathway

PROJECT_TITLE: Macrophage Plasticity in Inflammatory Lung Injury

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease

ORG_CITY: LAWRENCE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative The cycle of repeated composite-restoration replacements is a pernicious problem―each replacement risks pulpal injury, increased tooth weakness, and eventually, tooth loss. The problem is pervasive—nearly 70% of all composite restorations are replacements for failures. High-risk patients, such as the 4 million U.S. children and more than 100 million adults who do not receive regular dental care, are particularly vulnerable. The leading cause of failure is decay at the interface between the composite and tooth. This interface is initially sealed by an adhesive but the adhesive seal is weak and readily degraded. The proposed project will result in the following patient benefits: 1) substantial reduction in bacteria that infect the tooth margin; 2) ability to repair tooth structure damaged by bacteria, acids, and enzymes; 3) a self-strengthening adhesive that resists degradation; and 4) ~90% reduction in unreacted adhesive that could leach into the tissues of the mouth.

PI_NAMEs: SPENCER, PAULETTE  (contact);TAMERLER-BEHAR, CANDAN

PROGRAM_OFFICER_NAME: LOPEZ, ORLANDO

PROJECT_TERMS: Acids;Address;Adhesives;Adult;Amalgam;Anti-Bacterial Agents;antimicrobial;Bacteria;Biodegradation;cariogenic bacteria;Characteristics;chemical property;Child;Clinical;Composite Resins;composite restoration;Data;demineralization;Dental Care;Dentin;design;Deterioration;Engineering;Environment;Enzymes;Failure;Feedback;Fracture;high risk;Hydrolysis;improved;In Situ;in vivo;Infiltration;Injury;interfacial;life span;Liquid substance;Measurement;mechanical properties;Mechanics;Mediating;meetings;Microbial Biofilms;Modeling;monomer;novel;Oral;Oral cavity;Patients;Peptides;Performance;Plant Resins;Polymer Chemistry;Polymers;predictive modeling;Process;Proliferating;Property;Psychological reinforcement;Recurrence;remineralization;repaired;Resistance;restoration;restorative material;Risk;seal;Secondary to;Streptococcus mutans;Structure;System;Tissues;Tooth Loss;Tooth structure;Virulence;Viscosity

PROJECT_TITLE: Peptide-Polymer Engineering Dentin/Adhesive Interfacial Bond Integrity

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

PHR: Not applicable to the Administrative Core.

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Genetics;Lung;Neurosciences;Rare Diseases

PHR: Not applicable to Scientific Core.

PI_NAMEs: KARGINOV, ANDREI V (contact)

PROJECT_TERMS: analog;Animal Model;Avena sativa;Biology;calmodulin-dependent protein kinase II;Cell model;Chemicals;Chimera organism;Complex;CREB1 gene;Cyclic AMP-Dependent Protein Kinases;Development;dimer;Engineering;Enterobacteria phage P1 Cre recombinase;Enzymes;extracellular;G-Protein-Coupled Receptors;Genetic;Goals;Heterodimerization;improved;in vivo;Individual;Inflammatory;interest;JAK1 gene;Ligands;Light;Location;Lung;lung injury;Macrophage;Mediating;Methods;Molecular;mouse model;Neurospora crassa;novel;Nuclear;optogenetics;Participant;Pathway interactions;Phosphorylation;Phosphotransferases;Photoreceptors;phototropin;Process;Productivity;programs;protein activation;Protein Engineering;Protein Kinase;protein kinase A kinase;Proteins;Protocols documentation;Pulmonary Inflammation;Pyruvate Dehydrogenase Complex;Reagent;receptor;reconstruction;Regulation;Reporting;Resolution;Rhodopsin;Role;Signal Pathway;Signal Transduction;Sirolimus;STAT1 gene;STAT6 gene;synthetic biology;System;Technology;tool;transcription factor;Transcriptional Activation;wireless implant

PROJECT_TITLE: Synthetic Biology and Optogenetics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The emerging field of comparative oncology may provide a novel solution to rare human cancer studies, as genomic resources, reference genomes and non-human model cancer sequencing data are proliferating rapidly. We propose to, for the first time, develop and apply new machine learning methods to jointly analyze and integrate information from hundreds of mammalian genomes to identify pan-mammalian mechanisms of cancer resistance and susceptibility, and apply those insights in human cancers. To disseminate this date to the wider community and catalyze further research we will develop a tumor compendium, portal, and toolkit that will allow other researchers to leverage pan-mammalian comparative genomics.

PI_NAMEs: GRAIM, KILEY  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Adult;Affect;Algorithms;anti-cancer research;Atlases;Automobile Driving;Biological;biomedical scientist;cancer gene expression;cancer initiation;Cancer Model;Cancer Patient;cancer risk;cancer therapy;Clinical;cohort;Communities;comorbidity;comparative;comparative genomics;Comparative Study;Complement;Data;Databases;deep learning algorithm;Development;Early Diagnosis;Effectiveness;Epigenetic Process;Evolution;experience;Frequencies;Genes;Genetic;genetic resource;genetic signature;Genome;genome resource;genomic data;Genomics;Goals;Graph;high throughput analysis;Human;human data;human model;Immune system;improved;improved outcome;In Vitro;Incidence;Individual;insight;Joints;large scale data;Link;Machine Learning;machine learning method;machine learning model;machine learning prediction;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammalian Genetics;mammalian genome;Maps;Methods;Modeling;Neoplasm Metastasis;new therapeutic target;novel;Oncogenes;Oncology;open source library;Pan Genus;Pathway interactions;Patients;Pattern;Platinum;pre-clinical;precision medicine;Predisposition;Process;Proliferating;rare cancer;recruit;reference genome;Reporting;Research;Research Personnel;Resistance;Resources;Risk;Role;Sampling;Scientist;skills;success;Surveys;Time;tool;Training;Translating;tumor;tumor microenvironment;tumor progression;user-friendly;Variant;Work;Zoo Animals

PROJECT_TITLE: Leveraging Mammalian Cancers, Platinum-Quality Genome Assemblies, and Large-Scale Data to Identify Mechanisms of Rare Human Cancers

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]