NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Kidney Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: 8. PROJECT NARRATIVE Despite guidelines recommending dialysis initiation via an arteriovenous vascular access (fistula or graft), 80% of US patients start hemodialysis with a catheter, leading to significant morbidity, mortality, and healthcare system expense. In other chronic illnesses, strengthening patient preparedness through education and support has been shown to improve adoption of evidence-based health recommendations and associated patient outcomes. In this randomized controlled trial among people with advanced kidney disease planning for hemodialysis, we will compare the effectiveness of three education strategies for increasing pre-dialysis arteriovenous vascular access creation and evaluate the implementation of the education strategies to inform equitable and effective translation to the non-trial setting.

PI_NAMEs: CREWS, DEIDRA CANDICE;DEMBER, LAURA M;FLYTHE, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Acceleration;Address;Adherence;Adoption;arm;black patient;Black race;Blood Vessels;Caring;Catheters;Cessation of life;Characteristics;Chronic Disease;Chronic Kidney Failure;Clinic;Cohort Studies;combat;comorbidity;compare effectiveness;Complex;Consensus;coping;Counseling;Data;Data Coordinating Center;Dedications;design;Dialysis procedure;dietary;Disparity;Education;education access;Effectiveness;effectiveness/implementation study;Elements;Emotional;Emotions;Enrollment;Equity;Evaluation;evidence base;evidence based guidelines;experience;Fistula;Fright;Funding;General Population;Guidelines;Health;Health behavior;health disparity;Health Services Accessibility;Health system;Healthcare Systems;Hemodialysis;Hospitalization;Hybrids;implementation evaluation;implementation strategy;improved;Intervention;intrinsic motivation;Kidney Diseases;Kidney Failure;Knowledge;Methods;Mission;Morbidity - disease rate;mortality;motivational enhancement therapy;National Institute of Diabetes and Digestive and Kidney Diseases;Needles;North Carolina;Operative Surgical Procedures;Outcome;Pain;Patient Education;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pennsylvania;Persons;Population;Population Heterogeneity;primary outcome;Process;programs;Provider;Race;racial disparity;racial minority population;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Reporting;Research;Screening for cancer;secondary outcome;Self Efficacy;sociodemographics;System;Testing;Translations;treatment as usual;Uncertainty;uptake;Vaccines;Venous

PROJECT_TITLE: A Hybrid Type 1 Effectiveness-Implementation Study of Education Strategies for Vascular Access Creation in Advanced Kidney Disease

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE Obesity is primarily caused by an aberrant increase in feeding motivation that leads to the overeating of calorie- dense food. In this application, we propose to study zona incerta dopamine neurons for their role in the control of feeding motivation and food consumption. The expected outcome from this project will shed light on the mechanism by which central dopamine signaling regulate feeding and reveal a novel neural target for developing treatments in eating disorders and obesity.

PI_NAMEs: ZHANG, XIAOBING  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: adeno-associated viral vector;Affect;Aminobutyric Acids;Amygdaloid structure;Area;Behavioral;Behavioral Mechanisms;behavioral study;Brain;brain control;Brain region;Calcium Signaling;Calories;Consummatory Behavior;Consumption;Cues;Data;Development;Devices;Dopamine;Dopamine Antagonists;Dopamine D2 Receptor;dopaminergic neuron;Eating;Eating Disorders;Electrophysiology (science);Emotions;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Fiber;Food;food consumption;Food deprivation (experimental);Food Intake Regulation;frontal lobe;Genetic;Glucose;Goals;hedonic;Hunger;Hyperphagia;Hypothalamic structure;in vivo;inducible Cre;innovation;Limbic System;Mediating;Metabolic;Monitor;Motivation;Mus;neural;Neural Pathways;Neurons;novel;Nucleus Accumbens;Nutrient;Obesity;obesity risk;optogenetics;Outcome;patch clamp;Pathway interactions;Pattern;Peripheral;Photometry;Physiological;Pilot Projects;Play;postsynaptic;Prefrontal Cortex;Public Health;Regulation;Reinforcement Schedule;Reporting;response;Rewards;Role;Schedule;Signal Transduction;Site;Slice;Source;Subthalamic structure;System;Testing;Thalamic structure;Time;transmission process;Ventral Tegmental Area;Work;zona incerta

PROJECT_TITLE: Dopamine neurons in the zona incerta regulate feeding motivation

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Data Science;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative In this proposal we will identify genetic variants causing childhood-onset mitochondrial disease through the multi-omic approach of genome-wide sequencing, transcriptomics and metabolomics combined with mitochondrial functional studies in cell-based models of disease. This work will significantly advance the diagnosis and treatment of mitochondrial disease, as well as provide new insights into the mechanisms underlying the pathology of mitochondrial disorders and commonly occurring conditions associated with mitochondrial dysfunction such as neurological and neurodegenerative disorders.

PI_NAMEs: BONNEN, PENELOPE E (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;analysis pipeline;analytical method;analytical tool;Area;Ataxia;Automobile Driving;biobank;Bioinformatics;Biological;Biological Assay;Biological Markers;Body System;Cell model;Cells;Child;Childhood;Chronic;Chronic progressive external ophthalmoplegia;Clinical;clinical phenotype;Communities;Complement;Complementary DNA;Complex;computational reasoning;Consensus;Coupled;Data;Data Analyses;data integration;data mining;Data Security;Data Set;Databases;Defect;Development;Diagnosis;Diagnostic;Disease;disease model;disease-causing mutation;DNA;DNA sequencing;effective therapy;Electron Transport;empowerment;Encephalopathies;Etiology;Evaluation;Exhibits;exome;experience;Experimental Models;Functional disorder;functional genomics;gene discovery;Genes;Genetic;genetic variant;Genome;genome sequencing;genome-wide;Genomic approach;global health;Guidelines;heterogenous data;human disease;Huntington Disease;improved;Incidence;Individual;Inherited;innovation;insight;International;knock-down;Knock-in;knowledge base;Laboratories;Lentivirus Vector;Measures;Membrane Potentials;metabolome;metabolomics;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Molecular;Molecular Diagnosis;molecular diagnostics;Multiomic Data;multiple omics;Muscle hypotonia;Mutagenesis;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuromuscular;novel;Nuclear;Ontology;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Public Domains;Reactive Oxygen Species;Resources;RNA;Seizures;Series;Software Validation;Study Subject;System;Technology;Testing;Therapeutic;transcriptome sequencing;transcriptomics;Validation;Variant;variant of unknown significance;virulence gene;Visualization;whole genome;Work

PROJECT_TITLE: Personalized Functional Genomics for Mitochondrial Encephalopathy Gene Discovery

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SEATTLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Asymmetric cell division is an evolutionary conserved mechanism to create sister cells with different fates. This proposal investigates mechanisms involved in cellular and subcellular asymmetry, biased segregation of molecules and organelles and its contribution to binary cell fate decisions. Incorrectly regulated asymmetric cell division can result in tumor formation and neurodevelopmental disorders.

PI_NAMEs: CLEMENS C. CABERNARD, CLEMENS C (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acute;Affect;Behavior;Cell division;Cell Size;Cells;Central Nervous System;Centrosome;Chromatin;Cues;Cytoskeleton;Defect;Development;Drosophila genus;fly;Generations;Immunohistochemistry;in vivo;in vivo imaging;innovation;interest;Interphase;Kinesin;live cell imaging;Maintenance;Malignant Neoplasms;mechanical signal;Medical;Microtubule-Organizing Center;Mitosis;Molecular;Myosin Type II;nanobodies;nerve stem cell;neuroblast;Neurodevelopmental Disorder;non-muscle myosin;novel;optogenetics;Organ;Organelles;Organism;Pathway interactions;Process;programs;protein kinase N;Proteins;public health relevance;Reproducibility;Research;rho GTP-Binding Proteins;RNA;segregation;Siblings;Sister;Sister Chromatid;spatiotemporal;stem cells;Stereotyping;superresolution microscopy;System;Tissues;tool;Transcriptional Regulation;transcriptome sequencing;tumor

PROJECT_TITLE: Cell and mechanobiology of Asymmetric Cell Division

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Approximately 2-3% of trauma cases involve peripheral nerve damage. The treatment options for these injuries are limited, and clinical outcomes following surgical reconstructions can yield incomplete recovery, where estimates of adequate recovery are only achieved in 52% of cases. This project advances scientific knowledge on principles of nerve regeneration and functional recovery, where there is significant potential that the outcome of the research could lead to new therapies to improve the treatment of nerve injuries.

PI_NAMEs: WOOD, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: ACTL6B gene;Adaptive Immune System;Address;Affect;Allografting;Antibodies;Axon;B-Lymphocytes;CD19 gene;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Clinical;clinically relevant;cytokine;Data;Defect;Disadvantaged;eosinophil;Genes;Goals;Human;humoral immunity deficiency;Immune;Immune system;immunoregulation;Impairment;improved;Injury;Innate Immune System;innovation;Interleukin-4;Interleukin-5;Knockout Mice;Knowledge;Length;LoxP-flanked allele;Mediating;Modeling;Motor;Mus;Natural regeneration;Nerve;nerve autograft;nerve injury;Nerve Regeneration;nerve repair;Nervous System;Neurons;novel therapeutics;Outcome;Outcomes Research;Patient Care;peripheral nerve damage;Play;receptor;Reconstructive Surgical Procedures;Recovery;Recovery of Function;Regulation;repaired;restoration;Rodent Model;Role;Scientific Advances and Accomplishments;Signal Transduction;T-Cell Depletion;T-Lymphocyte;Trauma;Wild Type Mouse;Work

PROJECT_TITLE: T cell roles in regeneration across nerve graft alternatives

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Organ Transplantation;Prevention;Rare Diseases;Transplantation

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRITIVE Groundbreaking discoveries resulting in the “immuno-revolution” have established the importance of immunology across medical disciplines. However, the potential of targeting the immune system in the context of heart failure remains to be realized. The overarching goal of the proposed research program is to 1) dissect biological mechanisms governing cardiac macrophage diversity and function, and 2) translate our findings into new diagnostic and therapeutic approaches to abrogate heart failure pathogenesis, potentiate functional recovery of the failing heart, and prevent heart transplant rejection.

PI_NAMEs: LAVINE, KORY J. (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Adrenal Cortex Hormones;Anti-Inflammatory Agents;Biological;Cardiac;Cardiovascular Diseases;cell type;Clinical Research;Congestive Heart Failure;cytokine;Discipline;Disease;drug development;Etiology;experience;Goals;Graft Rejection;Heart;Heart Diseases;Heart failure;Heart Transplantation;Immune;Immune system;Immune Targeting;Immunology;improved outcome;Individual;Inflammation;Inflammation Mediators;Inflammatory;interest;Ischemia;Laboratories;Left Ventricular Remodeling;Macrophage;mechanotransduction;Medical;monocyte;Myocardial Infarction;novel diagnostics;novel therapeutic intervention;Pathogenesis;Patient-Focused Outcomes;Patients;prevent;programs;Recovery;Recovery of Function;recruit;Reporting;Research;Role;Serum;Signal Transduction;Specific qualifier value;Time;tissue repair;Tissues;TNF gene;Translating

PROJECT_TITLE: Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart Failure


ADMINISTERING_IC: EY

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEW HAMPSHIRE

ORG_STATE: NH

PHR: Salamanders can regenerate injured ocular tissues by relying on the cellular reprogramming ability of their  pigmented epithelium. Understanding this mechanism will provide a natural, safe and effective way to coax  human cells to regenerate lost or diseased eye tissues and improve vision.

PI_NAMEs: SOUSOUNIS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adolescent;Affect;Age;Age related macular degeneration;Aging;Ambystoma;American;Birds;Blindness;Cell Cycle;Cell Cycle Progression;Cell Reprogramming;Cell Separation;Cell Survival;Cells;comparative;Coupled;Couples;Cre-LoxP;Data;Diabetic Retinopathy;Disease;DNA Damage;Dorsal;Epithelial Cells;Event;Excision;Experimental Designs;experimental study;Eye;Eye diseases;Eye Injuries;Flow Cytometry;Future;Gene Expression;Gene Transfer Techniques;Genes;Genetic;genetic manipulation;Genotoxic Stress;Glaucoma;Goals;hallmarks of aging;Human;Immunohistochemistry;improved;in vivo;injured;Injury;insight;Iris;lens;lens regeneration;Life;Location;Mammals;Mentors;Methodology;Methods;Modeling;Molecular;Natural regeneration;Newts;novel;Pathway interactions;Patients;pharmacologic;Phase;Pigment Epithelium;Population;Predisposition;Process;progenitor;programs;Proliferating;promoter;protein protein interaction;Quantitative Reverse Transcriptase PCR;regeneration potential;regenerative;Regenerative Medicine;Regenerative response;Regulation;Rejuvenation;repaired;Research;response;Retina;Retroviridae;Risk Factors;Role;Salamander;single-cell RNA sequencing;Sorting;Source;spatiotemporal;stem;stem cell proliferation;stem cells;System;Testing;Therapeutic;Time;tissue regeneration;Tissues;transcription factor;transcriptomics;Transgenes;Transgenic Organisms;Translating;Tva receptor;vector;Virus;Vision;Western Blotting

PROJECT_TITLE: Elucidation of cellular reprogramming processes that drive lens regeneration in axolotl as a basis for future therapeutic approaches

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_DEPT: PHARMACOLOGY

ORG_STATE: NC

PHR: Narrative The University of North Carolina Alcohol Research Center will conduct, promote, support, and mentor research on the molecular and circuit pathogenesis of alcohol use disorders and educate broad groups of the public, including health professionals, families, college students and youth in North Carolina, on the causes and prevention of these disorders.

PI_NAMEs: KASH, THOMAS L. (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: addiction;Address;Adolescent;Alcohol abuse;alcohol abuse therapy;Alcohol dependence;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Animal Model;Behavior;Brain;brain dysfunction;Brain region;cell type;cellular pathology;Chronic;Collaborations;Dedications;design;Disease;disorder prevention;drinking;Education;Educational Curriculum;effective therapy;Elements;endophenotype;Equilibrium;Faculty;Family;Female;Fostering;Foundations;Functional Magnetic Resonance Imaging;Funding;Goals;Grant;Growth and Development function;Health;Health Professional;Human;improved;Information Centers;Information Dissemination;Investigation;Lead;Leadership;male;medical schools;member;Mentors;Modeling;Molecular;molecular pathology;National Institute on Alcohol Abuse and Alcoholism;neural circuit;Neurobiology;Neurosciences;North Carolina;Pathogenesis;Pathologic;Pathology;Pre-Clinical Model;Principal Investigator;problem drinker;professional students;Research;Research Personnel;Resources;Rest;Rodent;Role;Signal Transduction;synergism;System;Testing;Training;Translating;Universities;university student;Youth

PROJECT_TITLE: Molecular and Circuit Pathogenesis of Alcohol Use Disorders


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE We propose that EGFR functions as a switch in glioblastoma (GBM). Constitutive EGFR signaling leads to increased GBM invasion, while ligand-induced EGFR inhibition induces proliferation and inhibits invasion. We identify mechanisms involved in EGFR driven invasion and test a new treatment for GBM in a mouse model.

PI_NAMEs: HABIB, AMYN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Animal Model;Atlases;Automobile Driving;Biological;blood-brain barrier permeabilization;Cell Proliferation;Cells;Clinical;Cytoskeleton;Data;Dimerization;efficacy evaluation;EGFR Gene Amplification;EGFR inhibition;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;FDA approved;Glioblastoma;Glioma;Human;improved;Invaded;Ligands;Malignant neoplasm of brain;Malignant Neoplasms;malignant phenotype;MAP3K7 gene;MAP3K7IP1 gene;Mediating;Membrane;Modality;Modeling;mouse model;mutant;Mutation;novel;Oncogenes;Oncogenic;overexpression;Pathway interactions;Pattern;Pharmaceutical Preparations;PIK3CG gene;Prognosis;Proliferating;Proteins;Regulation;Reporting;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Tertiary Protein Structure;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;Transactivation;tumor;Tumor Expansion;tumor progression;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Bimodal EGFR signaling in glioblastoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Pediatric;Substance Misuse;Underage Drinking

PROJECT_TERMS: Advisory Committees;alcohol abuse therapy;Alcohol dependence;alcohol research;alcohol use disorder;alcoholism therapy;Alcohols;Appointment;Awareness;Brain;Brain region;Breathing;career;Collaborations;Communities;Community Outreach;community research;cost;Creativeness;Data;design;Development;Disease;drinking;editorial;Education;Educational workshop;Ethanol;Ethanol dependence;Event;Faculty;Family;Feedback;Fertilization;Fostering;Funding;Goals;Government;Health;Health Professional;improved;Information Dissemination;innovation;Institution;Investments;Knowledge;Lead;Leadership;Mediating;medical schools;meetings;Mentorship;minority scientist;Mission;Modeling;Molecular;Monitor;multidisciplinary;Museums;National Institute on Alcohol Abuse and Alcoholism;neural circuit;North Carolina;Parents;Pathogenesis;Pathology;Personnel Management;Pilot Projects;planetarium;post-doctoral training;Preparation;Prevention;Procedures;Process;Productivity;programs;Progress Reports;Reproducibility;Research;Research Activity;research data dissemination;research faculty;Research Methodology;Resource Sharing;Resources;Science;Scientist;Services;sex;Signal Pathway;Spanish/English;Study Section;Sum;symposium;synergism;Training;treatment program;underage drinking;Underrepresented Minority;Universities;university student;Update;web site;Work;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Neurosciences;Substance Misuse

PI_NAMEs: HODGE, CLYDE W (contact)

PROJECT_TERMS: Alcohol consumption;Alcohol dependence;alcohol measurement;alcohol research;alcohol use disorder;Alcohols;Archives;Behavioral;Biomedical Research;Brain;Brain region;Calcium;Collaborations;Computer software;Cost Savings;Data;Data Collection;data integration;data sharing;digital imaging;Electrophysiology (science);Environment;Equilibrium;Equipment;Evaluation;excitatory neuron;Fiber;Fluorescence;Fostering;Gene Expression;Goals;Human Resources;Image;imaging facilities;Imaging technology;Immunohistochemistry;Individual;inhibitory neuron;innovation;insight;instrumentation;interest;Lasers;Light;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;Measures;meetings;Methodology;Methods;Microscope;Modeling;Modernization;Molecular;neural circuit;neural network;new technology;novel;optogenetics;Pathogenesis;Pathologic;Pathology;Photometry;Play;Process;programs;protein expression;Quality Control;Rattus;Research;Research Design;Research Personnel;Research Project Grants;Resource Sharing;Resources;Reverse Transcriptase Polymerase Chain Reaction;Rodent;Role;Scanning;Services;Signal Transduction;Standardization;Synapses;Technical Expertise;Technology;transmission process;Western Blotting;Work

PROJECT_TITLE: Scientific Resource Core


ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE This project will reveal the critical roles of astrocyte-endothelial cell communication in the normal brain and in ischemic stroke by determining how the dynamics of astrocyte anatomy, physiology, and paracrine signaling regulate blood-brain barrier function through molecular, cellular, and physiological mechanisms.

PI_NAMEs: LEE, HYUN KYOUNG  (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Ablation;Address;Adult;Anatomy;Area;Arginine;Astrocytes;awake;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;blood-brain barrier function;Brain;Brain Injuries;Brain region;Cause of Death;CCL2 gene;Cell Communication;Cell Physiology;cell type;Cells;central nervous system injury;Cerebral Ischemia;chemokine;Conditioned Culture Media;Coupled;cytokine;Data;Degenerative Disorder;Disease;Endothelial Cells;Endothelium;Exhibits;extracellular;Extravasation;gain of function;Genetic;Gliosis;Goals;Health;Homeostasis;Impairment;In Vitro;in vivo;Infarction;Intercellular Junctions;Ischemic Stroke;Knowledge;loss of function;Maintenance;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Molecular;Morphology;motor disorder;mouse model;multiple omics;Mus;Nervous System Disorder;Neurodevelopmental Disorder;Neuroglia;novel;Oxides;Paracrine Communication;Pathogenesis;Pathologic;Pathway interactions;Patients;pH Homeostasis;Physiological;Physiology;Play;post stroke;prevent;Production;Property;response;Role;Signal Pathway;Signal Transduction;Sodium-Bicarbonate Symporters;Stroke;stroke patient;stroke risk;Testing;Time;Transgenic Mice;Variant

PROJECT_TITLE: Deciphering Mechanisms of Astrocyte-BBB Interaction in Normal and Ischemic Stroke


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

PI_NAMEs: ROBINSON, DONITA L (contact)

PROJECT_TERMS: addiction;Adolescence;adolescent binge drinking;Adult;Alcohol consumption;alcohol pharmacology;alcohol research;alcohol risk;alcohol use disorder;Alcohols;ARHGEF5 gene;binge drinking;Biological Sciences;Brain;Businesses;Charge;Child;Clinical;Collaborations;Communities;Community Health Education;Community Outreach;Development;Education;Educational Curriculum;Effectiveness;Evaluation;Event;Exhibits;Faculty;Family;Feedback;Fellowship;follow-up;Goals;hands-on learning;Health;High School Student;improved;Information Dissemination;insight;K-12 Education;Knowledge;Law Enforcement;Learning;Learning Module;lectures;life span;Measures;Medical;medical schools;Medicine;member;Mission;Molecular;Museums;National Institute on Alcohol Abuse and Alcoholism;Neurobiology;Neurosciences;Neurosciences Research;news;Nonprofit Organizations;North Carolina;offender;Oranges;outreach;Parents;Participant;Pathogenesis;Pathology;Pharmaceutical Preparations;planetarium;Policy Maker;Postdoctoral Fellow;Prevention;programs;Provider;Psychiatry;Publications;Research;research study;Research Support;Resources;Review Literature;Schools;Science;science museum;scientific literacy;Scientist;Services;Students;success;Surveys;synergism;Time;tool;Training;Translational Research;underage drinking;underage drinking reduction;Universities;university student;web site;working group;Youth

PROJECT_TITLE: Information Dissemination Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Metastatic cancer cells are able to colonize distant organs, resist therapy and cause cancer death because of their ability to dynamically change their gene expression programs to adapt to diverse stresses. The molecular mechanisms of such metastatic plasticity are not understood. Leveraging patient samples, organoids, and insights we have generated, we will define critical mechanisms of dynamic transcriptional reprogramming in metastasis, with the potential to impact therapeutic outcomes for patients with metastatic cancer.

PI_NAMEs: GANESH, KARUNA  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: 3' Untranslated Regions;Acceleration;Adherens Junction;Advanced Malignant Neoplasm;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Models;cancer cell;Cancer Etiology;cancer initiation;cancer stem cell;Cell Cycle;Cells;Cessation of life;Chromatin;Clinical;Colitis;Colon;Colorectal Cancer;colorectal cancer metastasis;Complex;crosslink;Cytoplasmic Granules;Data;derepression;Development;Disseminated Malignant Neoplasm;Distant;E-Cadherin;Elements;Engineering;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Family;Fluorescence;Gene Expression;Genes;Genetic;Genetic Transcription;Homeostasis;Immunofluorescence Immunologic;Immunoprecipitation;Impairment;in vivo;Injections;insight;intestinal epithelium;Intestinal Neoplasms;Intestines;Invaded;knock-down;Knock-in;LGR5 gene;Maintenance;Malignant Neoplasms;Mediating;Mediator;member;Messenger RNA;Modeling;Molecular;mouse model;mRNA Transcript Degradation;Mutation;Natural regeneration;Neoplasm Metastasis;neoplastic;Neural Cell Adhesion Molecule L1;neuroendocrine differentiation;Neurons;Neurosecretory Systems;novel;Oncogenes;Organ;Organoids;Outcome;Output;overexpression;Patient-Focused Outcomes;Patients;Phase;Phenotype;Physiologic pulse;Physiological;posttranscriptional;Primary Neoplasm;programs;Proliferating;protein complex;Proteins;Rectum;Recurrence;regenerative;regenerative cell;Regulation;repaired;Reporter;Resistance;response;restoration;RNA;RNA-Binding Proteins;Role;Sampling;self-renewal;single cell mRNA sequencing;stem cell organoids;stem cell self renewal;stem cells;stemness;Stress;Structure;Structure of splenic vein;therapeutic target;therapy outcome;Time;tissue regeneration;Tissues;transcriptional reprogramming;transcriptome sequencing;transcriptomics;tumor;tumor initiation;tumor progression;Tumor Suppressor Proteins;Untranslated Regions;whole genome;Work;wound healing;Xenograft procedure

PROJECT_TITLE: Mechanisms of Dynamic Transcriptional Reprogramming in Metastasis Stem Cells

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PROJECT_TERMS: Address;alcohol and other drug;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol use disorder;Alcohols;AMPA Receptors;Amygdaloid structure;Behavioral;behavioral study;Brain;Brain region;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcium;Calcium Signaling;calmodulin-dependent protein kinase II;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Data;Dependence;Development;DLG4 gene;drinking;Electrophysiology (science);Equilibrium;Ethanol;Ethanol dependence;excitatory neuron;Female;Fiber;Functional disorder;gamma-Aminobutyric Acid;Gene Deletion;Gene Expression;gephyrin;Glutamates;Goals;inhibitory neuron;innovation;Knowledge;Link;loss of function;male;Measures;Mediating;Membrane;men;Methods;Modeling;Molecular;Mus;neural;neural circuit;neuromechanism;Neuronal Plasticity;Neurons;neuropsychiatry;neurotransmission;novel;novel therapeutics;Nucleus Accumbens;Pathogenesis;Pathologic;Pathology;Pathway interactions;Permeability;Pharmaceutical Preparations;pharmacologic;Phase;Photometry;Physiological;postsynaptic;preclinical study;Prevalence;Property;receptor expression;Regulation;Research;Research Design;Resources;Rewards;Role;Self Administration;Signal Transduction;Site;Synapses;Synaptic Receptors;Testing;trafficking;vapor;Woman;Work

PROJECT_TITLE: Limbic glutamatergic circuits in ethanol dependence and escalated operant self-administration


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE: Overexposure to the essential metal manganese (Mn) results in  basal ganglia neurotoxicity and the development of incurable motor deficits. Proposed experiments aim  to determine whether Mn-induced dysfunction of GABAergic or catecholaminergic neurons in the basal  ganglia is associated with motor deficits. Proposed experiments also aim to further elucidate the role of  the primary Mn efflux transporter SLC30A10 in regulating brain Mn homeostasis.

PI_NAMEs: TAYLOR, CHERISH A (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Academia;Address;Adult;alpha synuclein;Basal Ganglia;Biological Assay;Brain;career;Child;Cognitive deficits;collaborative environment;Development;Endoderm;Environmental Health;Exhibits;experimental study;Exposure to;Functional disorder;gastrointestinal system;Gene Expression;Genetic;glycosylation;Goals;Homeostasis;human disease;interdisciplinary approach;Knock-out;Knockout Mice;Liver;Manganese;Manganism;Mentorship;Metals;Methods;Motor;motor deficit;Mutation;Nerve Degeneration;neurodevelopment;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosciences Research;neurotoxic;neurotoxicity;neurotransmission;novel;Occupational;Oral;Parkinson Disease;Phenotype;public health relevance;Risk;Role;schizophrenia risk;Source;Supervision;System;Testing;Texas;Toxicology;Training;Universities;Work

PROJECT_TITLE: Role of glycosylation in environmental and genetic schizophrenia risk


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative The Zika virus (ZIKV) is of major health concern due to its link to devastating pathologies such as microcephaly in newborn infants and the Guillan-Barré syndrome in adults. We have succeeded in identifying a novel “lead- like” compound (MS2045) for the inhibition of ZIKV’s RNA capping activity and for blocking its replication. We will design, synthesize, and characterize analogs of MS2045 that can be potentially developed into even more potent inhibitors of ZIKV replication.

PI_NAMEs: AGGARWAL, ANEEL K. (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 2019-nCoV;Adenine;Adult;Affinity;Americas;Amino Acids;analog;Anti-viral Agents;antiviral drug development;arthropod-borne;Attenuated;base;Binding;Binding Sites;Biological Assay;Biophysics;Cells;chemical synthesis;Chemistry;cofactor;Crystallization;Defect;Dengue Virus;design;Development;efficacy evaluation;Flavivirus;future outbreak;Goals;Health;Hepatitis C;HIV;Human;human pathogen;In Vitro;inhibitor;Lead;Life Cycle Stages;Link;Measures;member;Methylation;Methyltransferase;Microcephaly;Mutation;Newborn Infant;Nonstructural Protein;novel;pathogen;Pathogenicity;Pathology;Patients;Pharmaceutical Chemistry;Process;RNA;RNA Caps;RNA methylation;scaffold;structural biology;Structure;Structure-Activity Relationship;Syndrome;Testing;Uganda;vaccine development;Vaccines;Vero Cells;Viral;viral RNA;virology;Virus;Virus Replication;West Nile virus;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Development of MS2045 for inhibition of Zika methyltransferase

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Lung;Neurosciences

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Breathing is controlled automatically to preserve homeostasis but must also be conditionally regulated to adjust breathing to changes in behavior and emotion that typify the awake state. This project characterizes a novel neural circuit in the pons important for the state-dependent control of breathing at frequencies not achievable by known mechanisms of respiratory rhythm generation. Insights gained from these studies will significantly expand our basic scientific understanding of respiratory control with potential implications for pathologies that involve links between breathing and emotions such as panic disorders.

PI_NAMEs: BAERTSCH, NATHAN ANDREW (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TITLE: Unraveling a parabrachial circuit for the state-dependent  control of rapid breathing

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Neurosciences;Substance Misuse

PI_NAMEs: BESHEER, JOYCE  (contact)

PROJECT_TERMS: Agonist;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Anterior;Behavioral;Brain;Brain region;Cells;Chronic;Collaborations;Corpus striatum structure;cytokine;DLG4 gene;Dose;drinking;Electrophysiology (science);Equilibrium;Ethanol;excitatory neuron;experimental study;Female;functional loss;Functional Magnetic Resonance Imaging;Funding;Gene Activation;Gene Expression Profiling;Genes;Genetic;glial activation;Goals;Immunohistochemistry;Induced Neurons;Inflammatory;Interferon Type I;Interferons;ITGAM gene;knock-down;Label;Lifestyle-related condition;Ligands;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;male;Measures;Mediator;Microglia;Modeling;Molecular;Neuroimmune;neuroinflammation;Neurons;neurotransmission;Nucleus Accumbens;Pathogenesis;Pathologic;Pathology;prevent;Proteins;Rattus;Receptor Signaling;Research;Resources;Rest;Role;Self Administration;Signal Transduction;Synapses;System;Testing;therapeutic development;Tissues;TLR3 gene;TLR7 gene;TNF gene;Toll-like receptors;Training;transcription factor;vapor;Work

PROJECT_TITLE: The contribution of neuronal and microglia proinflammatory signaling in insular cortex on escalated ethanol self-administration


ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: REN, XUEFANG SOPHIE  (contact)

PROJECT_TERMS: Acute;Affect;aged;aging brain;Autopsy;Bioenergetics;Blood - brain barrier anatomy;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Brain Injuries;brain tissue;cell age;Cell Survival;cerebrovascular;Cognitive deficits;cognitive testing;comparison control;Complex;Data;Databases;deprivation;Development;Disease;EF Hand Motifs;effective therapy;Elderly;Electron Transport;Endothelial Cells;Endothelium;experimental study;Filament;Functional disorder;functional outcomes;Genes;Glucose;Goals;Hemorrhage;Human;human old age (65+);Impairment;improved;improved outcome;In Vitro;in vitro Model;in vivo;in vivo Model;Infarction;inhibitor;Integral Membrane Protein;Ischemia;Ischemic Stroke;Knock-out;Knockout Mice;Leucine Zippers;Magnetic Resonance Imaging;Maintenance;Measures;Mediating;Membrane Potentials;Messenger RNA;MicroRNAs;Middle Cerebral Artery Occlusion;Mitochondria;mitochondrial membrane;Mitochondrial Membrane Protein;Modeling;Molecular;Motor;motor function improvement;Mouse Strains;Mus;nanoparticle;nanoparticle delivery;novel;novel therapeutics;old mice;overexpression;Oxidative Phosphorylation;Oxygen;Persons;Plasma;Play;pre-clinical;Production;Proteins;Recovery of Function;Research;Role;Sampling;sex;Stroke;stroke model;stroke outcome;stroke patient;Structure;Testing;Therapeutic;therapeutic target;Transfection;Translational Repression;Vascular Cell Adhesion Molecule-1

PROJECT_TITLE: MicroRNAs, Mitochondria and the Blood-Brain Barrier - Therapeutic Targets for Stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Gain-of-function (GOF) p53 mutations are very frequent in all types of chemo- and radio-resistant intractable lung cancers with poor prognosis, and are required for their tumorigenic phenotype. The proposed project is designed to identify and validate small molecule inhibitors that specifically inactivate the oncogenic function of GOF p53 in tumors, sparing normal cells. Thus, the identified inhibitors should have a cancer cell-specific efficient therapeutic property for lung cancers with p53 mutation.

PI_NAMEs: DEB, SWATI P. (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Alleles;American Cancer Society;Animal Model;Apoptotic;cancer cell;Cancer cell line;Cancer Patient;cancer therapy;carcinogenesis;Cell Death;Cell Death Induction;cell growth;Cell model;Cell Proliferation;Cell Separation;Cells;Cessation of life;Data;Dependence;design;detection platform;experimental study;gain of function;Genes;Genetic;Genetic Transcription;genome-wide analysis;Goals;Growth;Human;Immunocompromised Host;Implant;inhibitor;Lung;lung cancer cell;Lung Neoplasms;lung xenograft;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;mouse model;Mus;mutant;Mutation;neoplastic cell;new therapeutic target;Normal Cell;novel;Oncogenic;patient derived xenograft model;Patients;Phenotype;Prognosis;Proliferating;Property;Publishing;radioresistant;Reporting;Sampling;small molecule inhibitor;Specificity;Squamous Cell;subcutaneous;Testing;Therapeutic;TP53 gene;Transactivation;Transcriptional Activation;Translating;tumor;tumor growth;tumor xenograft;tumorigenesis;tumorigenic

PROJECT_TITLE: Novel inhibitors of oncogenic p53 mutants for lung cancer therapy.


NIH_SPENDING_CATS: Regenerative Medicine

PHR: PROJECT NARRATIVE Why are some animals able to fully regrow lost appendages when humans cannot? In this proposal, we will identify features of the metabolic landscape that favor regenerative healing and growth using Xenopus tropicalis, a vertebrate that is able to regrow appendages under some conditions but not others.

PI_NAMEs: WILLS, ANDREA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: aerobic glycolysis;Anabolism;Animal Model;Animals;appendage;Articulation;Biological Metamorphosis;Carbon;cell growth;Cell Proliferation;cell type;Cells;Cellular Structures;Complex;Consumption;Coupled;Data;Data Set;Development;embryonic stem cell;Enzymes;experimental study;feeding;Fostering;Future;Gene Expression;Genetic Transcription;Glucose;glucose uptake;Glucose-6-Phosphate;Glycolysis;Goals;Growth;healing;Human;human tissue;Injury;inorganic phosphate;insight;Knowledge;limb regeneration;Limb structure;Link;Metabolic;metabolic profile;Metabolism;Modeling;Natural regeneration;Nucleotides;Nutrient;Organism;Outcome;Oxidative Phosphorylation;Pathway interactions;Pattern;Pentosephosphate Pathway;Phospholipids;Population;Process;Production;programs;Proliferating;Rana;regeneration model;regenerative;regenerative growth;regenerative healing;Regenerative Medicine;single cell analysis;Solid Neoplasm;Source;Specificity;stem cell population;Structure;success;Tadpoles;Tail;Testing;Time;tissue regeneration;Tissues;transcription factor;Warburg Effect;Work;Xenopus

PROJECT_TITLE: Decoding the metabolic requirements for vertebrate appendage regeneration

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

PI_NAMEs: BOETTIGER, CHARLOTTE A. (contact)

PROJECT_TERMS: Adolescence;Adolescent;adolescent alcohol exposure;adolescent binge drinking;Adult;Age;alcohol effect;alcohol exposure;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;analog;Animal Model;Anterior;ARHGEF5 gene;Basic Science;Behavior;Behavior assessment;behavior measurement;Behavioral;Bilateral;binge drinking;Brain;Cephalic;Chronic;clinical application;Collaborations;cost;Data;density;drinking;Electroencephalography;Electrophysiology (science);Encapsulated;environmental change;Equilibrium;Ethanol;Exposure to;flexibility;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Genetic;genetic approach;Glutamates;Glutamine;high risk;high risk drinking;hippocampal pyramidal neuron;Human;human subject;Image;improved;indexing;Individual;Insula of Reil;Interneurons;Light;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Mediating;Mediator;Molecular;neural;neurochemistry;Neurocognitive;Neurons;Output;Parvalbumins;Pathogenesis;Persons;Population;Prefrontal Cortex;Rattus;Recording of previous events;recruit;Reporting;Resources;response;Rest;Reversal Learning;Risk;Rodent;Signal Transduction;Slice;stem;Techniques;Testing;therapeutic target;tool;translational approach;Translations;Treatment Efficacy;Work;World Health Organization

PROJECT_TITLE: Frontolimbic circuitry, behavioral flexibility, and adolescent alcohol history


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse;Women's Health Research

PI_NAMEs: HERMAN, MELISSA A (contact)

PROJECT_TERMS: Acute;Alcohol dependence;alcohol effect;alcohol exposure;alcohol sensitivity;alcohol use disorder;alcohol use initiation;Alcohol withdrawal syndrome;Alcohols;Allopregnanolone;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;anxiety-like behavior;Aversive Stimulus;Brain;Brain region;Calcium;cell type;Chronic;Clinical;Complex;cortico-limbic circuits;Data;Electrophysiology (science);Equilibrium;Ethanol;experience;Female;Fiber;Functional disorder;imaging approach;imaging study;Immediate-Early Genes;Impairment;improved;in vivo;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;male;Measures;Mediating;men;Mental Depression;Molecular;neurobiological mechanism;Neurons;neurosteroids;optogenetics;Oral;Pathogenesis;Pathology;pharmacologic;Phenotype;Photometry;pre-clinical;Predisposition;Prefrontal Cortex;Prevalence;Rattus;receptor;Relapse;Research;response;Rest;Role;sex;Sex Differences;Slice;Specificity;Stress;Synapses;Synaptic Transmission;Testing;Therapeutic;Time;treatment strategy;Water;whole animal imaging;Withdrawal;Woman;Work;young woman

PROJECT_TITLE: Sex specificity of corticolimbic circuit activity and anxiety-like behavior after alcohol exposure


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE (Public Health Relevance) Attention Deficit Hyperactivity Disorder (ADHD) is a condition that affects tens of millions of adults and is often associated with increased susceptibility to interference by irrelevant external stimulation which can adversely affect home and work life. In this project, we propose to (1) use a new method to study susceptibility to interference from irrelevant external information, (2) model the results from this method to uncover the underlying processing difficulties faced by those with ADHD, and (3) apply this method to three different tasks both of which feature the need to control interference.

PI_NAMEs: JONIDES, JOHN  (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;Adolescent;Adopted;Adult;Advisory Committees;Affect;Age;Attention deficit hyperactivity disorder;Attentional deficit;Behavioral;Child;Clinical;clinical diagnosis;computer framework;Computer Models;Conflict (Psychology);Control Groups;critical period;Data;design;Diagnosis;Diagnostic;Disease;Education;executive function;experimental study;Failure;Functional disorder;Gender;General Population;Goals;Home;Impairment;Individual;Individual Differences;individual response;Life;Literature;Methodology;Methods;Modeling;Neurodevelopmental Disorder;novel;novel strategies;parallel processing;Participant;Patient Self-Report;Patients;Persons;Predisposition;prevent;Process;processing speed;Production;psychologic;public health relevance;recruit;Research;Resources;response;Rest;Sampling;screening;Source;Stimulus;Stream;Symptoms;Testing;Time;Work

PROJECT_TITLE: Investigating interference-control in ADHD using a novel forced-response method

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Lupus;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative This R21 proposal aims to analyze the potential of tissue kallikreins (klk), an important set of molecules in the kallikrein-kinin system (KKS), in lupus-prone mouse models (MRL/lpr and Sle1,2,3). Experiments in vitro will analyze the effects of klk1(one of the tissue klks) on brain cells (microglia, astrocytes and microvessels [that form the blood-brain-barrier]), and klk1 administration in MRL/lpr mice will assess the disease outcome (clinical, immunological, and behavioral). There is currently no specific treatment for neuropsychiatric (NPSLE) lupus; the results of this study will provide a rationale to use tissue klks for systemic and NPSLE treatment.

PI_NAMEs: SRIRAM, UMA  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Age;Alzheimer's Disease;angiogenesis;Angiotensin-Converting Enzyme Inhibitors;Anxiety;anxiety-like behavior;Applications Grants;Astrocytes;Attenuated;attenuation;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;Behavior;Behavioral;Biological Markers;Blocking Antibodies;Blood;Blood - brain barrier anatomy;blood pressure control;Blood specimen;blood-brain barrier crossing;Bradykinin;Brain;brain cell;Captopril;Central Nervous System;Chronic;Clinic;Clinical;Clinical Trials;Coagulation Process;Complex;Congenic Mice;Data;Dendritic Cells;depressive symptoms;Development;Diagnosis;Disease;disease heterogeneity;Disease Outcome;experimental study;Failure;Family;Funding;Gene Expression;Genes;Goals;Human;Immunologics;immunoregulation;Impaired cognition;improved;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Interferon alpha;Interferons;Ischemia;Kallikrein-Kinin System;Kidney;Kininogenase;Kininogens;Lupus;Lupus Nephritis;lupus prone mice;Malignant Neoplasms;Mental Depression;Microglia;Modeling;mouse model;Multiple Sclerosis;Mus;Nervous System Disorder;neuroinflammation;neuropsychiatric symptom;Neuropsychiatric Systemic Lupus Erythematosus;Onset of illness;Oral Administration;Outcome;Outcome Study;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;Plasma;Pre-Clinical Model;Process;Production;Psychoses;Publications;receptor;Regulation;Renin-Angiotensin System;Research;response;Role;Serine Protease;SLEB1 gene;Spleen;Study models;Susceptibility Gene;Symptoms;Systemic Lupus Erythematosus;Testing;Therapeutic;therapeutic candidate;Therapeutic Intervention;therapeutic target;Therapeutic Uses;Time;Tissue Kallikrein;Tissues;Virus Diseases

PROJECT_TITLE: Potential of tissue kallikreins as therapeutic targets for neuropsychiatric lupus

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Neurochemicals in the brain, such as serotonin, transmit information between neurons to process input and produce normal behavior, but that occasionally when their levels are disrupted lead to neurologic and psychiatric disorders. We are proposing to develop a novel neurochemical recording method called N-shaped Multiple Cyclic Square Wave Voltammetry that for the first time measures tonic serotonin concentrations in real-time in the brain with single-second time resolution and unprecedented chemical selectivity. Furthermore, we propose to standardize this novel technique for use in neuroscience research directed to understanding the neurochemical basis of neuropsychiatric diseases by demonstrating its capability to quantify tonic levels in both acute and chronic animals.

PI_NAMEs: LEE, KENDALL H. (contact);OH, YOONBAE ;SHIN, HOJIN

PROJECT_TITLE: Development of an innovative in vivo voltammetric technique for measurements of tonic serotonin concentrations in the mammalian brain.

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

PI_NAMEs: KASH, THOMAS L. (contact)

PROJECT_TERMS: Address;adolescent alcohol exposure;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;Amygdaloid structure;Anterior;Attention;Behavioral Assay;Brain;Chronic;Collaborations;Data;Dependence;Development;Electrophysiology (science);Elements;Equilibrium;Ethanol;experimental study;Fiber;Genetic;genetic approach;Goals;Health;hippocampal pyramidal neuron;Insula of Reil;Intake;Interneuron function;Interneurons;Learning;Link;Lithium Chloride;Maps;Measures;Mediating;Molecular;Motivation;Mus;neural;neural circuit;neural network;neuromechanism;Neurons;novel;novel therapeutic intervention;Nucleus Accumbens;Output;Parvalbumins;Pathogenesis;Pathway interactions;Photometry;Physiology;Play;pre-clinical;Process;Property;Public Health;Regulation;Research;Resources;Retrieval;Rewards;Rodent;Role;Site;Slice;Structure;Symptoms;Taste aversion;Taste Perception;Testing;tool;transmission process;Up-Regulation;Work

PROJECT_TITLE: Role of insula circuitry in the regulation of the aversive properties of ethanol


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Endocrine Disruptors;Microbiome;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research will demonstrate that the gut microbiome acts in concert with the direct effects of envi- ronmental toxicants, such as polychlorinated biphenyls (PCBs), on the brain and the influence of these interac- tions on neurotoxic outcomes, such as Alzheimer’s Disease and Related Dementias (ADRD). This outcome is relevant to public health because it will provide critical insights regarding the plausibility of microbiome-based approaches to diagnose and treat neurodevelopmental and neurodegenerative disorders induced by exposure to PCBs and, potentially, other neurotoxicants. Therefore, the proposed research is pertinent to the part of NIH’s mission that seeks to develop fundamental knowledge about living systems to enhance health and reduce the burden of human disease.

PI_NAMEs: LEHMLER, HANS-JOACHIM  (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;APP-PS1;Attenuated;bile acid metabolism;Bile Acids;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier function;Brain;Cause of Death;Cognition Disorders;comparison control;Complex;Control Animal;Data;data reuse;Dementia;Development;Diagnosis;Disease;Dose;Elderly;Ensure;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiology study;Etiology;Experimental Models;Exposure to;FAIR principles;Family member;Female;Functional disorder;genetic risk factor;Goals;gut bacteria;gut microbiome;Health;Healthcare;Homeostasis;Human;human disease;in vivo;Inflammatory Response;insight;intestinal barrier;Intestines;Iowa;Knowledge;Lead;life span;male;Measures;Mediating;Mediation;Memory Loss;Metabolism;microbiome;microbiome composition;Mission;Modeling;mouse model;Mus;Neurodegenerative Disorders;Neurodevelopmental Disorder;neurotoxic;Neurotoxins;object recognition;Organism;Outcome;Pathologic;Pathology;Persons;Phenotype;Polychlorinated Biphenyls;pre-clinical;premature;prevent;programs;Proteins;Public Health;Quality of life;Research;Ribosomal RNA;Role;Senile Plaques;Serum;Severities;Systems Biology;tau-1;Testing;Tight Junctions;Time;Tissues;Toxic effect;Toxic Environmental Substances;translational study;United States;United States National Institutes of Health;Universities;Vascular Diseases

PROJECT_TITLE: Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction


NIH_SPENDING_CATS: Biotechnology;Cancer;Coronaviruses;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We are studying how viruses that cause lymphomas or sarcomas in humans or monkeys use RNA molecules to manipulate their host cells to the advantage of the virus. These RNAs are not templates for making proteins but act to alter how other genes function after infection. Understanding these viral noncoding RNAs will provide novel targets for the design of therapeutics to combat these cancer-causing viruses, as well as many insights into host-cell processes.

PI_NAMEs: STEITZ, JOAN A. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;Adopted;B-Lymphocytes;Binding;Biogenesis;Biological;Callithrix;Cancer Patient;Cebidae;cell growth;cell growth regulation;Cell Nucleus;Cell Physiology;cell transformation;Cells;Collaborations;combat;Coronavirus;crosslink;Cytoplasm;Databases;design;Diagnostic;differential expression;DNA biosynthesis;Elements;Epstein-Barr virus encoded RNA 2;Evolution;expectation;Gene Expression;gene function;Genome;Goals;Herpesviridae;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune response;Immune signaling;Immunocompromised Host;In Vitro;Individual;Infection;Infectious Agent;Infectious Mononucleosis;insight;Investigation;leukemia/lymphoma;Lymphoid Cell;Lymphoma;Lytic;Lytic Phase;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;messenger ribonucleoprotein;Messenger RNA;MicroRNAs;Molecular;Monkeys;mRNA Export;Mutagenesis;mutant;novel;Nuclear;Nuclear Export;Oncogenic;Poly A;Population;Primates;Process;Production;Protein Biosynthesis;Protein Engineering;Proteins;Proteome;Resolution;Ribonucleoproteins;RNA;RNA Databases;RNA Sequences;RNA Stability;RNA-Binding Proteins;Roentgen Rays;Role;Saimiriine Herpesvirus 2;Sarcoma;SARS-CoV-2 genome;SARS-CoV-2 infection;Shapes;Signal Transduction;Small RNA;Structure;System;T-Lymphocyte;Tail;Testing;Therapeutic;Transcript;transcriptome;transforming virus;triple helix;Untranslated RNA;Viral;viral DNA;Viral Proteins;viral rescue;Virion;Virus

PROJECT_TITLE: Viral Noncoding RNAs and Cell Transformation

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: MURDOCH CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The global burden of disease due to Group A Streptococcus (GAS) is a major unmet public health challenge. After more than 100 years of vaccine development efforts, resurgent momentum flowing from investment in discovery and design of next generation GAS vaccines remains threatened by the absence of a human correlate of protection and the limitations of currently available in vitro assays and preclinical models. Our cross- disciplinary collaborative research aims to strengthen the development pathway for novel GAS vaccine candidates by applying cutting edge human immunology tools and techniques to diverse human specimens to discover broadly applicable potential correlates of systemic and mucosal protection that will inform design of scalable, high-throughput, practical immunoassays.

PI_NAMEs: NORRBY-TEGLUND, ANNA ;STEER, ANDREW  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Animal Model;Antigens;Bacteria;Biological Assay;Blood specimen;burden of illness;Cells;Cellular Immunology;Characteristics;Child;Clinical;Clinical Trials;cytokine;design;Development;Disease;experience;Failure;functional group;Funding;Future;Gene Expression;Goals;Human;human model;Immune;Immune response;Immunoassay;Immunocompetent;immunogenicity;Immunology;in vitro Assay;in vivo;Infection prevention;Inflammatory Response;insight;International;Investments;Knowledge;Liquid substance;Modeling;Mucosal Immune Responses;Mucous Membrane;next generation;novel;Oral;Outcome;Outcomes Research;pathogen;pathogenic bacteria;Pathway interactions;Peripheral Blood Mononuclear Cell;Pharyngitis;Phase;pre-clinical;Pre-Clinical Model;programs;Public Health;Publishing;Research;research and development;response;sample collection;Sampling;Scourge;Signal Transduction;Source;Specimen;Standardization;Streptococcal Infections;Streptococcal Vaccines;Streptococcus pyogenes;Syndrome;System;systemic inflammatory response;Techniques;Testing;Tissue Model;Tissues;Tonsil;tool;transcriptomics;Tube;Vaccinated;Vaccine Antigen;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine development;vaccine discovery;vaccine evaluation;vaccine-induced immunity;Vaccines;Whole Blood

PROJECT_TITLE: Assays for acceleration: from fit-for-purpose models to scalable assays of broad systemic and mucosal protection against all strains of Group A Streptococcus


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The biomedical community lacks a complete description of the effects, frequencies, and molecular nature of causative variants underlying complex genetic diseases and other quantitative traits. The multiparental population we pioneered, and continue to develop here, enables powerful genetic dissection of trait variation in the premier fruit fly model system, and allows a community of users a smooth transition from mapped genomic regions to sequence variants. Our resource is complementary to GWAS (genomewide association study) methods, and under several likely genetic models has distinct advantages over this approach for the identification of causative variation.

PI_NAMEs: LONG, ANTHONY DOUGLAS;MACDONALD, STUART JOHN (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Alleles;analytical method;Animals;Architecture;Biological Models;Biology;causal variant;Cell Differentiation process;Cell Physiology;cohort;Collection;Communities;Complex;Computer software;Consensus;Control Animal;Data;Data Set;data visualization;design;Diagnostic;Disease;Dissection;DNA Transposable Elements;Drosophila genus;empowerment;Equilibrium;Event;Experimental Designs;experimental study;Fat Body;flexibility;fly;Frequencies;Future;Gene Expression;Gene Frequency;Generations;Genes;Genetic;Genetic Diseases;Genetic Models;genetic resource;genetic variant;Genome;genome resource;genome sequencing;genome wide association study;Genomic Segment;Genotype;Goals;Haplotypes;Health;Heterogeneity;Human;human disease;Immune response;Immunologics;improved;Inbreeding;Individual;Infection;insight;Learning;life history;Link;Maps;Mediating;Memory;Mendelian disorder;Mental Depression;Methods;model organism;Modeling;Molecular;mosaic;Movement;multidimensional data;Mutation;Nature;novel;novel strategies;pathogen;Pharmaceutical Preparations;Phenotype;Population;predictive modeling;Process;Quantitative Trait Loci;rare variant;Reaction;Recombinants;Recurrence;Regulation;Research;Research Personnel;Resolution;Resources;response;Sampling;segregation;Site;Structure;System;Techniques;Testing;Therapeutic;Time;Tissues;tool;Toxic effect;trait;transcriptome sequencing;Update;usability;user-friendly;Validation;Variant;Vial device;whole genome;Xenobiotics

PROJECT_TITLE: A Resource for the Genetic Dissection of Complex Traits

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Immunoglobulin heavy chain germline gene IGHV6-1 encodes a multi-donor class of broadly neutralizing antibodies (bnAbs) to the highly conserved stem region of hemagglutinin (HA). This proposed study aims to characterize the sequence features and affinity maturation pathways of IGHV6-1 HA stem bnAbs. The results will provide important mechanistic insight into the development of universal influenza vaccines.

PI_NAMEs: WU, NICHOLAS C. (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Affinity;Antibodies;Antibody Repertoire;Antibody Response;antigen binding;Antigens;Avian Influenza A Virus;Binding;biophysical analysis;Biophysical Process;complementarity-determining region 3;Cross Reactions;design;Development;Epidemic;Epitopes;Evolution;experimental study;Frequencies;Genes;Genetic;Germ Lines;global health;Head;Heavy-Chain Immunoglobulins;Hemagglutinin;Human;Immunoglobulin Somatic Hypermutation;Individual;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N9 Subtype;Influenza A Virus, H9N2 Subtype;Influenza Hemagglutinin;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;innovation;insight;interdisciplinary approach;interest;Light;Membrane Glycoproteins;Molecular;neutralizing antibody;pandemic disease;pandemic potential;Pathogenicity;Pathway interactions;Point Mutation;Public Health;Reporting;SARS-CoV-2 antibody;seasonal influenza;Somatic Mutation;Spanish flu;Specificity;stem;structural biology;System;transmission process;universal influenza vaccine;Update;V(D)J Recombination;vaccine effectiveness;Variant;Virus;Yeasts;Zoonoses

PROJECT_TITLE: Sequence-function relationship of influenza broadly neutralizing antibodies

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome;Prevention

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Human gut microbiome composition has recently been associated with a wide array of diseases, including inflammatory bowel disease (IBD) and colorectal cancer. We propose to study the structure and function of the gut microbiota in the development of IBD associated colorectal cancer. Our proposed study may lead to better understanding of the interplay between gut microbiota and colon mucosa and could shed light to novel diagnostic and therapeutic approaches to IBD and associated colorectal cancer.

PI_NAMEs: CHEN, RU  (contact);PAN, SHENG

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Affect;Animal Model;Apoptosis;Bacteria;Bacterial Genes;Bioinformatics;Biological;Biological Models;Biopsy;Cancer Detection;cancer prevention;cancer risk;cancer therapy;carcinogenesis;Chronic;Clinical;Clinical Research;colitis associated cancer;Colitis associated colorectal cancer;Colon;Colorectal Cancer;design;Development;dextran sulfate sodium induced colitis;Disease;DNA Damage;dysbiosis;Enzymes;Epithelium;Event;fecal microbiota;Genes;Genomic Instability;gut microbes;gut microbiome;gut microbiota;Gut Mucosa;Human;human microbiota;Immune response;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Integration Host Factors;interest;Intestinal Cancer;Investigation;Knowledge;Laboratories;Light;Longitudinal Studies;Malignant Neoplasms;Metabolism;metaproteomics;microbial;microbial community;microbiome;microbiome composition;microbiota;microbiota composition;microbiota profiles;Modeling;Molecular;mouse model;mucosal microbiota;Mucous Membrane;Mus;new technology;novel diagnostics;novel strategies;novel therapeutic intervention;Organoids;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;phosphoproteomics;Proliferating;protein expression;Proteome;Proteomics;Rectum;Research;Resources;response;Risk;Role;Sampling;Signal Pathway;Specimen;statistics;Structure;Study models;Surface;System;Systems Biology;Taxonomy;Techniques;Technology;tool;translational potential;tumor progression;tumorigenic;Ulcerative Colitis;Work

PROJECT_TITLE: Elucidating the role of gut microbiota in colitis-associated colorectal cancer

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Polycomb group (PcG) genes encode a group of proteins that can maintain gene repression by modifying chromatin. This proposal seeks to study the mechanisms and functions of PcG proteins in mouse preimplantation development. This study will reveal key insights on chromatin reprogramming in mouse early development and facilitate our understanding the human developmental processes to reduce early pregnancy loss.

PI_NAMEs: CHEN, ZHIYUAN  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affinity;Alleles;Auxins;Award;Biochemical;Bioinformatics;Biological Assay;blastocyst;Boston;Cells;Chromatin;chromatin modification;Chromatin Structure;Classification;Cleavage Under Targets and Release Using Nuclease;Complex;computational pipelines;computer framework;Cultured Cells;Data;Deposition;Development;Developmental Biology;Developmental Gene;Developmental Process;DNA Methylation;DNA-Binding Proteins;early pregnancy loss;Embryo;Environment;epigenetic memory;epigenomic profiling;epigenomics;Event;Exhibits;Feedback;Fertilization;gene repression;Gene Silencing;Genes;Genetic Transcription;Genome;genome-wide;Genomic Imprinting;Genomics;Germ Cells;Germ Lines;Histone H2A;Histone H3;Human;human disease;insight;interest;Lysine;Malignant Neoplasms;Maps;Mediating;medical schools;Mentors;Methylation;Michigan;Molecular;Mus;Oocytes;overexpression;Pathway interactions;Pediatric Hospitals;Phase;Phenotype;Physiological;Play;Polycomb;PRC1 Protein;Pre-implantation Embryo Development;preimplantation;premature;Process;protein degradation;protein function;Proteins;recruit;Regulation;Research;Research Personnel;Role;stem cell biology;System;Techniques;tool;Totipotency;Training;transcriptome sequencing;ubiquitin isopeptidase;United States National Institutes of Health;Universities;Variant;Work;zygote

PROJECT_TITLE: Genomic and functional analyses of Polycomb group proteins in mouse preimplantation development


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The proposed research is relevant to NEI mission because it investigates the fundamental principles of pathological mechanisms contributing to retinal degeneration. Our work will provide novel mechanisms leading to the progression of eye diseases and illuminate therapeutic interventions aimed at reversing vision loss.

PI_NAMEs: POLEG-POLSKY, ALON  (contact)

PROGRAM_OFFICER_NAME: HENLE, STEVEN JOHN

PROJECT_TERMS: Address;advanced disease;Affect;Age;American;Animal Model;Area;Automobile Driving;Axon;axon injury;axonopathy;Biophysics;blind;Blindness;Brain Diseases;Brain region;Calcium;Cell Death;cell injury;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;demographics;design;Development;Disease;Disease Management;Disease Progression;Early Diagnosis;Early treatment;Electrophysiology (science);Equilibrium;excitotoxicity;experimental study;Exposure to;Eye;Eye diseases;Feedback;Functional disorder;Glaucoma;Glutamates;Goals;Healthcare;Human;Image;Impairment;improved;In Vitro;Individual;Injury;innovation;insight;interest;Intervention;Intrinsic factor;Knowledge;Light;Link;Mediator;Metabolic;Metabolic stress;Mission;Modality;Modeling;Monitor;Morphology;mouse model;Mus;N-Methyl-D-Aspartate Receptors;Nerve Crush;nerve damage;Nerve Degeneration;Nervous System Disorder;neural circuit;Neuronal Injury;Neurons;neuropathology;neuroprotection;Neurotransmitters;novel;Optic Nerve;optic nerve disorder;optimal treatments;Output;Pathologic;Pathology;Pathway interactions;Physiologic Intraocular Pressure;Physiological;Population;Predisposition;Preparation;preservation;pressure;Prognosis;Property;repaired;Research;response;Retina;retinal axon;retinal damage;Retinal Degeneration;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Role;simulation;Structure;Surface;Survival Rate;Synapses;Testing;Therapeutic Intervention;tool;Trauma;Traumatic Brain Injury;Traumatic injury;Vision;Visual;visual information;visual processing;Work

PROJECT_TITLE: Mechanisms of NMDAR contribution to traumatic injury in retinal ganglion cells

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Food Allergies

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: NARRATIVE: Mast cells play a critical role in the induction of immune responses, promoting both IgE-dependent allergic responses such as food allergy and non-IgE-mediated inflammatory diseases such as rheumatoid arthritis. Our studies provide a unique opportunity to dissect the mechanisms by which IL-10 modulates mast cell function in the context of both IgE-mediated activation as well as IgE- independent signals such as IL-33 stimulation. These investigations will not only provide key mechanistic insight into the proinflammatory effects of IL-10 on activated mast cells, but also further enhance our understanding of how mast cells promote the development of allergic responses towards better therapeutic approaches.

PI_NAMEs: MATHIAS, CLINTON B (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adoptive Transfer;Allergens;Allergic;Allergic inflammation;allergic response;Anaphylaxis;Antiinflammatory Effect;Antiparasitic Agents;Attenuated;autocrine;Automobile Driving;Bone Marrow;CD4 Positive T Lymphocytes;cell behavior;Cell Culture Techniques;Cell Line;Cell Lineage;cell mediated immune response;Cell Physiology;cell type;Cells;Cellular Immunity;Chymase;conditioning;Connective Tissue;cytokine;Data;Development;Disease;egg;Enhancers;Event;Exhibits;food allergen;food antigen;Food Hypersensitivity;Goals;Heterogeneity;Homeostasis;Human;Hypersensitivity;IgE;Immune;Immune response;Immunodeficient Mouse;immunoregulation;Inflammation;Inflammatory;Inflammatory Response;Ingestion;insight;Interleukin-10;Interleukin-13;Interleukin-4;Interleukin-6;Interleukin-9;Intestines;Investigation;Light;Maps;mast cell;mastocytosis;Mediating;Mission;Modeling;Mucous Membrane;Mus;National Institute of Allergy and Infectious Disease;Nature;novel;Outcome;paracrine;Pathologic;Pathway interactions;Peritoneal;Pharmaceutical Preparations;Phenotype;Physiological;Play;Population;Production;Proliferating;prototype;Reaction;receptor;Regulation;Regulatory T-Lymphocyte;Reporting;response;Rheumatoid Arthritis;Role;Shapes;Signal Pathway;Signal Transduction;Skin Tissue;Source;Stem Cell Factor;Stimulus;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th2 Cells;Therapeutic;Therapeutic Intervention;Tissues;transcriptomics;Transforming Growth Factor beta;tumor-immune system interactions

PROJECT_TITLE: Differential regulation of mast cell-mediated allergic responses by IL-10

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative The future of medicine depends on biomedical research and the new discoveries that research brings to disease mechanisms. However, disparities exist, not only in healthcare and disease but also in researchers who push biomedicine forward. The VCU IMSD program is intended to address this disparity by increasing the number of underrepresented minorities who pursue PhD level training in biomedical research.

PI_NAMEs: AKBARALI, HAMID I (contact);ESCALANTE, CARLOS R

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Program Development;Students

PROJECT_TITLE: VCU Initiative for Maximizing Student Development Program (IMSD)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE We hypothesize that mutant p53 drives the pathogenesis of myelodysplastic syndromes (MDS) through altering pre-mRNA splicing in hematopoietic stem and progenitor cells (HSPCs) during aging. We will determine the mechanisms by which mutant p53 alters pre-mRNA splicing in HSPCs. We will determine the sensitivity of human MDS cells with TP53 mutations to spliceosome inhibitor treatment and develop novel therapeutic strategies for MDS patients with TP53 mutations.

PI_NAMEs: BARAJAS, SERGIO  (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute Myelocytic Leukemia;aged;Aging;aging population;aging related;Alleles;Apoptosis;Biochemical;Biological;Biological Assay;Cells;Clonal Expansion;cytokine;Disease;Dysmyelopoietic Syndromes;Elderly;Epigenetic Process;Exhibits;EZH2 gene;Gene Expression;Gene Mutation;Genes;Genetic;Health Benefit;Hematologic Neoplasms;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;Histones;Human;in vivo;Inflammation;Inflammatory Response;inhibitor;Interleukin-1 beta;Interleukin-6;Knowledge;Life;Literature;Malignant Neoplasms;Messenger RNA;Modeling;Molecular;mRNA Precursor;mutant;Mutant Strains Mice;Mutate;Mutation;novel;novel therapeutic intervention;Outcome;Pathogenesis;Patients;pharmacologic;prevent;Prognosis;progression risk;Proliferating;Protein Isoforms;Publishing;Research;Risk;RNA Splicing;Role;Somatic Mutation;Spliceosomes;SRSF2 gene;stem cell aging;stem cell expansion;stem cells;TP53 gene;transcriptome sequencing;Tumor Suppressor Genes

PROJECT_TITLE: Mutant p53 in pathogenesis of Myelodysplastic Syndromes


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Narrative We will determine the mechanisms that chromosome segregation and determine how these are dysregulated in tumors. We focus on the regulation of Aurora B kinase, which is an important target for new cancer therapies. In addition, we will determine how the complex containing Aurora B generates important structures on the mitotic spindle that segregates chromosomes and resolves R- loops during mitosis, which are structures that can generate genomic instability when they are not properly regulated.

PI_NAMEs: STUKENBERG, P. TODD  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;aurora B kinase;cancer cell;cancer therapy;Cellular Assay;Centromere;Centrosome;Chromosome Segregation;Chromosomes;cohesion;Complex;Defect;Ensure;Event;Generations;Genetic Transcription;Genomic Instability;Human;in silico;In Vitro;in vivo;inhibitor;insight;Investigation;Kinetochores;Liquid substance;Malignant Neoplasms;Mammary Neoplasms;member;Microtubule Bundle;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Mitotic spindle;Modeling;mutant;novel;Phase;Phosphorylation;Phosphotransferases;Physical condensation;Physiological;Prophase;Proteins;Reaction;reconstitution;Regulation;Signal Transduction;Sister Chromatid;Structure;tool;Transcript;tumor

PROJECT_TITLE: Mechanisms of mitotic regulation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MILWAUKEE

ORG_NAME: VERSITI WISCONSIN, INC.

ORG_STATE: WI

PHR: PROJECT NARRATIVE Most patients with chronic myeloid leukemia (CML) require life-long therapy with BCR-ABL1 tyrosine kinase inhibitors (TKIs) to avoid relapse. CML cells minimize expression of membrane-spanning four A (MS4A3) to escape TKIs. We will identify the underlying mechanism, and whether re-expression of MS4A3 can be harnessed to increase response to TKIs.

PI_NAMEs: DEININGER, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: ABL1 gene;Acute;Acute leukemia;Affect;Aggressive-Phase Myeloid Leukemia;Apoptosis;Attenuated;biological adaptation to stress;Blast Phase;Blood;Bone Marrow Transplantation;CD34 gene;Cell Cycle;Cell Differentiation Induction;Cells;Chronic Myeloid Leukemia;chronic myeloid leukemia cell;Chronic-Phase Myeloid Leukemia;Clinical;cofactor;Constitution;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Dependence;differentiation in vitro;drug sensitivity;Endocytosis;Family;Fluorouracil;Granulocyte-Macrophage Colony-Stimulating Factor;Hematopoiesis;Hematopoietic;Hematopoietic System;Human;IL3 Gene;Image;improved;In Vitro;in vivo;inhibitor;inhibitor therapy;knock-down;Knock-out;leukemia;Leukemic Cell;leukemic stem cell;leukemogenesis;live cell imaging;Malignant - descriptor;Maps;Mass Spectrum Analysis;Mediating;member;Membrane;Messenger RNA;Mouse Strains;Mus;Myelogenous;Myeloid Cells;nanoparticle;Normal Cell;novel;Outcome;overexpression;Pathway interactions;Patients;Phase;Phenotype;Philadelphia Chromosome;Phosphotransferases;Physiological;Prevalence;prevent;Printing;Protein Array;Protein Tyrosine Kinase;Proto-Oncogene Proteins c-abl;Publishing;receptor;Recurrence;Relapse;Reporting;Residual state;Resistance;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Stress;Testing;Therapeutic Agents;therapy resistant;transcriptome;Tumor Suppressor Proteins;Tyrosine Kinase Inhibitor;Undifferentiated;Work;Xenograft procedure

PROJECT_TITLE: The function of MS4A3 in normal and malignant hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(02)M]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: COLLEGE STATION

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: PROJECT RELEVANCE  The orphan nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in colon cancer patients and this receptor not only regulates genes associated with tumor cell growth, survival and invasion but also plays a pivotal role in immune suppression and T-cell exhaustion. Bis-indole derived agents (CDIMs) developed in our laboratories are high affinity ligands (and antagonists) of NR4A1 and their dual role as chemotherapeutic and immunotherapeutic agents will be investigated in cell culture and mouse colon tumor models.

PI_NAMEs: ABDELRAHIM, MAEN ;CAI, JAMES JING;SAFE, STEPHEN H. (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Affinity;Age;Alcohol consumption;angiogenesis;antagonist;Antibodies;Binding;cancer cell;cancer diagnosis;capecitabine;Cell Culture Techniques;cell growth;Cells;Cessation of life;Chemopreventive Agent;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;clinical application;Colon;colon cancer patients;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer treatment;Complement 2;Complex;Coupled;Cytotoxic agent;Death Rate;Developed Countries;Developing Countries;Development;dietary;Disease;disorder risk;Distal;DNA Sequence Alteration;Drug Combinations;Drug Targeting;Drug usage;Early Diagnosis;early screening;Epidermal Growth Factor Receptor;ERBB2 gene;exhaustion;Exhibits;Family history of;Fluorouracil;Generations;Genes;Genetic;genetic risk factor;Growth;high risk;high-fat/low-fiber diet;Histologic;Human;Immune checkpoint inhibitor;Immune system;Immunologic Surveillance;Immunologics;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;Incidence;Income;Individual;Indoles;Infection;Inherited;Intake;Intestines;Invaded;KDR gene;Knockout Mice;Laboratories;Leucovorin;lifestyle factors;Ligands;Link;Location;Malignant Neoplasms;Meat;men;Modeling;Molecular;mouse model;Mus;Neoadjuvant Therapy;neoplastic cell;NR4A1 gene;NR4A2 gene;Nuclear Orphan Receptor;Obesity;Oncogenic;Operative Surgical Procedures;overexpression;oxaliplatin;Pathologic;Pathway interactions;Patients;Pharmacotherapy;Phosphotransferases;Play;precision medicine;programmed cell death ligand 1;Radiation;receptor;Rectal Cancer;Recurrent disease;Regulation;Research;Risk Factors;Role;Sampling;sedentary lifestyle;sex;single cell analysis;Smoking;stem cells;T-Lymphocyte;Therapeutic;therapeutic effectiveness;Time;tumor;tumor growth;tumor microenvironment;Tumor stage;Tumor-Infiltrating Lymphocytes;United States;Vascular Endothelial Growth Factors;Woman;women versus men;Xenograft procedure;young adult

PROJECT_TITLE: NR4A1 Antagonists Inhibit Colorectal Cancer Growth and Enhance Immune Surveillance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Genetics;Microbiome

ORG_CITY: SEATTLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The focus of this fundamental mechanistic project is to determine the microbial and host factors underlying variations in gingival inflammatory responses across the human population. Ultimately this basic information may provide the basis to guide treatments based on host response type.

PI_NAMEs: DARVEAU, RICHARD PETERS;MCLEAN, JEFFREY SCOTT (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Bacteria;Cell Count;chronic inflammatory disease;Clinical;clinical phenotype;Communities;Coupled;Custom;cytokine;Data Set;Dental Plaque;design;Development;Disease;DNA;Educational workshop;Foundations;Gingiva;Gingival Crevicular Fluid;Gingivitis;Goals;Growth;Health;Homeostasis;host-microbe interactions;Human;Immune;Immune response;Immunoassay;In Vitro;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Integration Host Factors;Intervention;Investigation;Knowledge;Measurement;Measures;Mediator;metabolomics;Metagenomics;microbial;microbial community;microbiome;Modeling;Multiomic Data;multiple omics;novel;oral microbiome;Participant;Pattern;Periodontic specialty;Periodontitis;personalized medicine;Phase;Phenotype;Population;Predisposition;preservation;Preventive;Primary Prevention;Process;Public Health;Regulation;Research;resilience;Resistance;Resolution;response;Ribosomal DNA;Ribosomal RNA;RNA;Sampling;subgingival microbiome;subgingival microbiota;success;Testing;Therapeutic;Time;Tissues;Translating;Treatment Protocols;treatment strategy;Variant;Work

PROJECT_TITLE: Mechanisms underlying the variation in rate and levels of gingival inflammatory responses among the human population


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE  Stuttering negatively impacts communication and reduces the overall quality of life and well-being of individuals who stutter. The proposed research program is directly relevant to the NIH’s mission because the project’s findings will form a strong foundation for developing neural and behavioral interventions for stuttering. In addition, this project’s findings will inform theories of speech by describing the contributions of predictive processes to fluent speech production.

PI_NAMEs: DALIRI, AYOUB  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Adult Stuttering;Auditory;auditory feedback;Auditory system;Behavior Therapy;Behavioral;Brain;Characteristics;Child;Clinical;Communication;cost;Detection;Development;Etiology;Evaluation;Exposure to;Feedback;Foundations;Goals;improved;Individual;individual variation;Intervention;Left;life span;Methods;Mission;Monitor;Motor;Motor Cortex;Movement;neural;neurobehavioral;neurophysiology;Occupational;Outcome;Output;Personal Satisfaction;Population;Predisposition;Process;Production;programs;Protocols documentation;Quality of life;Relapse;Research;Research Project Grants;response;Role;sensory system;Signal Transduction;social;socioeconomics;Speech;speech accuracy;Speech Delay;speech fluency disorder;Stuttering;Techniques;Testing;theories;transcranial direct current stimulation;Transcranial magnetic stimulation;United States National Institutes of Health;Well in self

PROJECT_TITLE: Auditory prediction and error evaluation in the speech of individuals who stutter

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The immune system is capable of slowing or preventing cancer progression; however, the immune tolerance of cancer significantly hinders protective anti-tumor immune responses, and leads to treatment failures and poor patient survival. We uncovered that melanoma-associated Schwann cells inhibit the formation of the tertiary lymphoid structures in tumors and promote immunosuppression, favoring immune tolerance and cancer progression. We will determine the molecular mechanism of tumor immunity regulation by the Schwann cells, and target them genetically and pharmacologically as a novel therapeutic strategy aimed at breaking the immune tolerance and synergizing with anti-PD-1 and anti-CTLA4 immune checkpoint inhibitors.

PI_NAMEs: BUNIMOVICH, YURI  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Acceleration;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-1;anti-tumor immune response;Area;Autoimmune;Autonomic nervous system;cancer cell;Cancer Model;cancer therapy;cancer type;Cell Therapy;Cells;Cellular biology;Clinical;clinically relevant;Communication;Elements;Endothelial Cells;evidence base;Exclusion;expectation;Extracellular Matrix;Fibroblasts;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune system;Immune Tolerance;Immunocompetent;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;Inflammatory;Invaded;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Melanoma;Melanoma Tumor;Molecular;mouse model;Multiple Sclerosis;Natural regeneration;Neoplasm Metastasis;Nerve;nerve repair;nerve supply;Neurodegenerative Disorders;Neuroglia;Neurons;Neuropathy;Neuropeptides;Neurotransmitters;NGFR Protein;novel;novel strategies;novel therapeutic intervention;Pain;Patients;perineural;Peripheral;Peripheral Nervous System;pharmacologic;Play;prevent;Process;promoter;Property;Publishing;Regulation;repaired;Reporting;Research;response;Role;Schwann Cells;Signal Transduction;Spinal cord injury;Syndrome;synergism;targeted treatment;tertiary lymphoid organ;Testing;tissue repair;Tissues;Transgenic Organisms;translational oncology;Treatment Failure;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-Associated Vasculature;Tumor-infiltrating immune cells;Wallerian Degeneration;Work

PROJECT_TITLE: The Role of Schwann Cells in the Progression of Melanoma

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Our network of study sites initiated Regional Prospective Observational Research in TB (RePORT)-Brazil in 2013 in Rio de Janeiro, Salvador, and Manaus, Brazil, with the data coordinating center at Vanderbilt. Clinical data and stored biorepository specimens have facilitated studies of TB and TB/HIV treatment outcomes, predictors of M. tuberculosis (Mtb) infection and progression to TB disease and incipient TB, TB-diabetes, drug-resistant TB, TB diagnostics, and Mtb transmission. Phase 2 of RePORT-Brazil will build upon this strong foundation through three Specific Aims: 1) Gain insights that improve TB diagnosis, treatment, and outcomes; 2) Improve our understanding of Mtb transmission and infection, including latent, incipient, and sub-clinical disease; predictors of progression to TB, and protection against TB; and 3) Support and develop the next generation of TB scientists, and enhance the scope and collaboration of RePORT-Brazil.

PI_NAMEs: ANDRADE, BRUNO DE BEZERRIL;STERLING, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: ESPY, NICOLE JOY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;biobank;Biological Assay;Biological Markers;Blood;Brazil;C-reactive protein;career development;Caribbean region;Categories;Cellular Phone;Central America;Characteristics;China;Clinical;Clinical Data;cohort;Collaborations;Collection;Country;Data;Data Coordinating Center;Databases;Dedications;Demographic Factors;design;Diabetes Mellitus;Diagnosis;Diagnostic tests;Disease;Disease Notification;DNA;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;Enrollment;Epidemiology;Ethambutol;experience;Fellowship;fluoroquinolone resistance;Fluoroquinolones;follow-up;Fostering;Foundations;Funding;Future;Genomics;Global Positioning System;Grant;Growth;Hemoglobin;HIV;HIV/TB;Immunology;improved;Incidence;Incubators;India;Individual;Indonesia;Infection;inflammatory marker;insight;Interferon Type II;International;Intervention;isoniazid;Molecular Epidemiology;Morbidity - disease rate;mortality;Mycobacterium tuberculosis;neutrophil;next generation;novel;novel diagnostics;Observation in research;Outcome;outcome prediction;Participant;participant enrollment;Pathogenesis;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacogenomics;Phase;Philippines;Pilot Projects;Plasma;point of care;Population;Postdoctoral Fellow;Prediabetes syndrome;predictive modeling;Predisposition;Prevention;progression risk;prospective;Publications;Pulmonary Tuberculosis;Pyrazinamide;Registries;Research;Research Personnel;Resource-limited setting;Rifampicin resistance;Rifampin;Risk;Risk Factors;RNA;Role;Science;Scientific Advances and Accomplishments;Scientist;Sentinel;Site;South Africa;South America;Specimen;Sputum;Statistical Methods;System;transcriptomics;transmission process;Treatment outcome;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;tuberculosis treatment;United States;Urine;Validation;Weight Gain;Whole Blood;Work;World Health Organization

PROJECT_TITLE: Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Complementary and Integrative Health;Hearing Loss;Neurosciences;Prevention;Rehabilitation

PHR: PROJECT NARRATIVE This study employs a novel approach to investigate the effects of channel interaction and a strategy that promotes channel independence to improve cochlear implant (CI) outcomes that require high-fidelity spectral encoding, such as music perception. Study results could provide the first evidence-based recommendations for programming CIs for music, which is of immediate interest to clinicians for counseling patients and programming devices, CI candidates for increasing utilization of CIs, and CI recipients for improving their performance and quality of life. More broadly, this study is of interest to CI researchers and manufacturers by providing a foundational model and preliminary data to inform future work striving to improve performance on other spectral tasks, such as speech understanding in background noise and musical sound quality and appraisal.

PI_NAMEs: BERG, KATELYN  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Action Potentials;Address;Adult;Affect;Apical;Auditory;Awareness;Behavioral;Cochlear Implants;Communication;Counseling;Cueing for speech;Cues;Data;design;Development;Devices;Discrimination;Effectiveness;Electric Stimulation;Electrodes;evidence based guidelines;experimental study;Faculty;Frequencies;Funding;Future;Goals;Image;implantation;Implanted Electrodes;improved;instrument;interest;Knowledge;Liquid substance;Manufacturer;Measures;Mediating;member;Methods;Mirza;Modeling;Music;neural;Neurobiology;Noise;noise perception;novel strategies;open data;Outcome;Outcomes Research;Participant;Patients;Pattern;Perception;Performance;Pitch Discrimination;Pitch Perception;Psychophysics;Quality of life;Research;Research Personnel;Rest;Sensorineural Hearing Loss;signal processing;simulation;skills;sound;Speech;Speech Acoustics;speech in noise;speech recognition;standard care;Statistical Data Interpretation;Stimulus;Techniques;tenure track;Testing;Training Programs;United States National Institutes of Health;Universities;Width;Work

PROJECT_TITLE: Optimizing cochlear implants for music perception