NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: Stress is a major risk factor for physical and psychological health problems, and has been strongly linked with anhedonic symptoms in major depressive disorder (i.e., “Stress-induced anhedonia”). The goals of the current proposal are to characterize the brain networks associated with a recently identified glutamatergic stress- response profile in medial prefrontal cortex that has been found to be impaired in patients with major depressive disorder, and determine whether it can be restored using the glutamate receptor antagonist ketamine. By establishing the glutamate stress response as a mechanism for anhedonic effects of chronic stress and its reversal by ketamine, these data will be able to serve as a drug discovery platform for other pharmacologic agents targeting the glutamate system that may be useful in treating stress-induced anhedonia

PI_NAMEs: TREADWAY, MICHAEL TILGHMAN (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: 3-Dimensional;Acute;acute stress;Anhedonia;Animals;Anterior;Area;Attenuated;Behavior assessment;Behavioral;Behavioral inhibition;biological adaptation to stress;Brain;Brain imaging;Brain-Derived Neurotrophic Factor;Chronic;Chronic stress;Clinical Research;Collection;Corpus striatum structure;Data;Decision Making;disability;disability risk;Dorsal;Dose;Double-Blind Method;drug discovery;Event;Excitatory Amino Acid Antagonists;expectation;Exposure to;Failure;Female;follow-up;Functional Magnetic Resonance Imaging;Future;Glutamates;Goals;Hippocampus;Hour;Human;Impairment;improved;Individual;Infusion procedures;Intervention;Intravenous;Ketamine;Laboratories;Link;Machine Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Medial;Mediating;Mental Health;Modeling;Motivation;multimodality;neural;Neurocognitive;neuroimaging;neuroprotection;NMDA receptor antagonist;novel;Pathway interactions;Patients;perceived stress;Peripheral;pharmacologic;Pharmacological Treatment;physical conditioning;Placebos;Plasma;Positive Valence;preclinical study;Prefrontal Cortex;psychosocial;Randomized;Regulation;Research Domain Criteria;Resolution;response;Rewards;Risk Factors;Role;Sampling;Scanning;Series;Stress;stressor;suicidal risk;Symptoms;System;targeted agent;Translating;treatment response;ultra high resolution;Ventral Striatum

PROJECT_TITLE: Glutamatergic adaptation to stress as a mechanism for anhedonia and treatment response with ketamine

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative: Recent experimental discoveries demonstrate that Irg-1/itaconate might be a novel therapeutic targeting molecule for preventing secondary brain damage after traumatic brain injury (TBI). This project will pursue three specific aims to test our central hypothesis: Irg-1/itaconate modulates multiple bioenergetics and neurovascular inflammatory signaling pathways of microglia and cerebrovascular endothelium, including preserving mitochondria oxidative phosphorylation (OXPHOS), while suppressing hyperglycolysis/NFκB activation, but activating Nrf2 signaling pathway, which results in inhibition of microglia activation-associated neuroinflammation (Aim-1), and BBB integrity disruption (Aim-2). These actions interactively prevent secondary brain damage and ultimately improve long-term neurological outcomes of TBI (Aim-3).

PI_NAMEs: WANG, XIAOYING  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Acute;Biochemical;Bioenergetics;Biological Assay;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;brain tissue;Caprylates;Cell Separation;Cells;Central Nervous System Diseases;Cerebral endothelium;cerebrovascular;Cerebrum;Citric Acid Cycle;Clinical;Data;Development;effective intervention;Endothelial Cells;Endothelium;Energy Metabolism;Enzymes;Extravasation;fatty acid metabolism;Genes;Genus Hippocampus;glial activation;Glucose;Glutamine;High-Throughput RNA Sequencing;Homeostasis;Immune;immunoregulation;improved;Inflammatory;Inflammatory Response;Injury;insight;Knowledge;Mediating;Metabolic;Metabolism;metabolomics;Microglia;Mitochondria;mitochondrial permeability transition pore;Molecular;molecular pathology;Mus;Nerve Degeneration;neuroinflammation;Neurologic Deficit;Neurological outcome;neurovascular;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Outcome Assessment;oxidation;Oxidative Phosphorylation;Pathologic;Pathway interactions;pharmacologic;Phase;Phenotype;Play;preservation;prevent;Protein Overexpression;Proteins;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;Sodium;stable isotope;Stress;Supplementation;Testing;transcription factor;Transcriptional Activation;transcriptomics;Transducers;Transgenic Organisms;Traumatic Brain Injury;Vascular Endothelium

PROJECT_TITLE: Role of Irg-1/itaconate in modulating secondary brain damage after traumatic brain injury in mice

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This application proposes the first ever in-human test of a neurosurgical treatment called high intensity focused ultrasound to see if it is safe and tolerated, and if it can reduce anxiety and brain response to threat in patients with partial epilepsy that is resistant to medications. Current treatments for anxiety disorders, the most prevalent mental illness, are limited by modest efficacy and require strict adherence and continuation to work. By studying this new treatment comprehensively, this study will examine if and how focused ultrasound works and provide insights that will guide best practices and reduce risk for future clinical trials in anxiety and other psychiatric disorders.

PI_NAMEs: LUCAS, TIMOTHY H;PHAN, K. LUAN  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Ablation;Acute;Adherence;Aftercare;Amygdaloid structure;Anatomy;Anterior;Anterior Nuclear Group;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;Attenuated;Behavior;Biological Assay;Brain;brain based;Clinical;clinical anxiety;Clinical Trials;Cognitive Therapy;cohort;Collaborations;conventional therapy;Data;Deep Brain Stimulation;Devices;Disease remission;Dose;Epilepsy;Essential Tremor;experience;experimental study;FDA approved;first-in-human;Focused Ultrasound;Focused Ultrasound Therapy;Fright;Functional Magnetic Resonance Imaging;Future;Human;Human Anti-Mouse Antibody;image guided;innovation;insight;Intervention;Intractable Epilepsy;Laboratories;Lesion;Localized Lesion;Location;Magnetic Resonance;Magnetic Resonance Imaging;Major Depressive Disorder;Measures;Medial;Mediating;Medical;Mental disorders;Meta-Analysis;neural;Neurologic;Neuropsychology;neuroregulation;Neurosurgeon;neurosurgery;novel;Obsessive-Compulsive Disorder;Partial Epilepsies;Participant;Pathologic;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacotherapy;phase I trial;Phenotype;Physical environment;Postoperative Period;Prefrontal Cortex;psychiatric comorbidity;Psychotherapy;Refractory;Relapse;Reporting;Resistance;response;Rest;Risk;Risk Reduction;safety assessment;Sampling;Selective Serotonin Reuptake Inhibitor;Site;Sonication;Structure;Substance Addiction;Suicide;Symptoms;Techniques;Temporal Lobe;Testing;Thalamic structure;Therapeutic Effect;Thermal Ablation Therapy;Time;Transcranial magnetic stimulation;treatment of anxiety disorders;ultrasound ablation;United States Food and Drug Administration;Ventral Nuclear Group;Work

PROJECT_TITLE: Magnetic Resonance-guided Focused Ultrasound Ablation of the Anterior Thalamus as a Novel Treatment Paradigm for Anxiety


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Usher Syndrome

ORG_DEPT: NEUROSCIENCES

ORG_NAME: LSU HEALTH SCIENCES CENTER

PHR: Project Narrative There are no treatments to prevent or slow progression of disease in patients with Usher syndrome, the leading cause of combined deafness, imbalance, and retinitis pigmentosa. Studies proposed in this application will use multidisplinary approaches to define the progression of vestibular dysfunction in an Usher syndrome type 1C mouse model and in patients, and continue to assess the efficacy of two novel treatments (antisense and gene replacement) that restore balance in the mouse model. Results from this project will provide the foundation for translation of the treatments in the mouse into clinical trials in patients with Usher syndrome.

PI_NAMEs: GELEOC, GWENAELLE S;LENTZ, JENNIFER JEAN (contact);ZHOU, WU

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 1 year old;Address;adeno-associated viral vector;Adult;Affect;Age;Age Months;age related decline;Aging;Antisense Oligonucleotide Therapy;Behavioral;Biological Markers;Blindness;Canada;Childhood;Clinic;Clinical;clinical outcome measures;Clinical Trials;cohort;Communication;deafness;Disease;Disease Progression;Dose;drug candidate;Ear Diseases;effective therapy;Effectiveness;efficacy evaluation;equilibration disorder;Equilibrium;Evoked Potentials;Exhibits;first-in-human;Foundations;Frequencies;Future;gene replacement;gene replacement therapy;gene therapy;Genes;Genetic;Goals;Hair Cells;Head;Health;Hearing;hearing impairment;Human;human study;interest;Knock-in Mouse;Knowledge;Lead;Length;Life;Longevity;Louisiana;Measurable;Measures;Medical;Messenger RNA;Molecular;Morphology;mouse model;multisensory;Mus;Mutation;National Institute on Deafness and Other Communication Disorders;Natural History;Neonatal;neurophysiology;novel;optimal treatments;Organ;otoconia;Outcome;Patients;Pediatric cohort;Persons;Population;prevent;prospective;Proteins;Rare Diseases;Research Support;Retinitis Pigmentosa;RNA Splicing;Rotation;Saccule structure;Sensory;Sensory impairment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapy development;Time;Tissues;transcriptome sequencing;Translations;Treatment Efficacy;Treatment Protocols;treatment strategy;USH1C gene;Usher Syndrome;Usher Syndrome Type 1;Usher Syndrome Type 1C;Variant;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;vestibular system;vestibulo-ocular reflex;Vision;young adult

PROJECT_TITLE: Vestibular dysfunction and the development of therapies for Usher syndrome

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This project aims to examine the effects of the new Home Care Rule (HCR) by the Department of Labor which allowed certain types of home care services to be protected by federal minimum wage and overtime rules in 2015, using advanced empirical methods and two large, nationally representative data sets. This new HCR could substantially change the utilization of and the spending on home care service for older adults with and without Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD). Findings from this study will have significant policy implications, as the size and the life expectancy of the older adult population, especially the population with AD/ADRD, and the costs of health care continue to rise, putting unprecedented pressure on the health care system.

PI_NAMEs: WANG, YANG  (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;care providers;care recipients;Caregivers;Caring;Complex;cost;Cost Analysis;Costs and Benefits;County;Data;Data Set;design;Diagnosis;Dimensions;Education;Educational Status;Ethnic Origin;Event;Exclusion;experience;Family;Friends;Future;Gender;geographic difference;Health;Health and Retirement Study;Health Care Costs;Health Insurance;Health Personnel;Healthcare Systems;Home;Home Care Services;Household;human old age (65+);improved;Individual;informal care;innovation;insight;Institution;institutional care facility;Insurance Coverage;interest;Life;Life Expectancy;Literature;Long-Term Care;Low income;Marital Status;Marketing;Measures;Medicaid;Methods;Natural experiment;Nursing Homes;Occupations;older adult;Outcome;patient home care;Patient Self-Report;Persons;Play;Policies;policy implication;Policy Maker;Population;Positioning Attribute;pressure;Prevention;programs;Quasi-experiment;Race;Regulation;Research;Role;Services;System;Testing;Time;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;Variant;Wages

PROJECT_TITLE: Federal Minimum Wage Expansion and Home Care Utilization and Costs for Older Adults

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: MD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Triple-negative breast cancer disproportionately affects Black/African American women, is difficult to treat and is the deadliest type of breast cancer. We have identified a protein that is required for the growth of some triple-negative breast cancer cells. This study will identify the factors that make a triple-negative breast cancer cell dependent on this protein and identify a small molecule inhibitor of the protein.

PI_NAMEs: COTTRELL, KYLE  (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Address;Adenosine;Affect;African American;African American Women;African Women;bench to bedside;Biological;Biological Assay;Black race;BRCA mutations;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;career development;Cell Line;Cell Proliferation;Cells;chemotherapy;Classification;Clinical Data;Data;Data Correlations;Deaminase;Deamination;Death Rate;Dependence;Development;Disease;Disparity;disparity reduction;DNA;Double-Stranded RNA;dsRNA adenosine deaminase;Enzymes;Exhibits;experience;Gene Expression;Genes;Genetic Transcription;genomic data;Grant;Growth;high throughput screening;immunogenic;implantation;inhibitor;Inosine;Interferons;knock-down;Lead;Left;Malignant Breast Neoplasm;Mammary Neoplasms;Modeling;Monitor;mouse model;Mutation;new therapeutic target;Nucleotides;Oranges;outcome disparities;Pathogenicity;Pathway interactions;patient derived xenograft model;patient population;Patient-derived xenograft models of breast cancer;Patients;performance tests;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Process;Proliferating;Proteins;racial disparity;research and development;Research Personnel;RNA;RNA Folding;side effect;Signal Transduction;small molecule;small molecule inhibitor;small molecule libraries;Structure;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumorigenesis;White Women;Work

PROJECT_TITLE: Identifying determinants of ADAR-dependency in triple-negative breast cancer


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative A central goal of toxicology is to predict the clinical effects that can result from specific toxic exposures, especially for chemicals with incomplete or insufficient experimental data. The proposed research provides tools, methods, and real-world applications for predicting these effects computationally by adapting and extending techniques from translational bioinformatics and artificial intelligence, while addressing specific issues that have limited the success of computational toxicology in the past.

PI_NAMEs: ROMANO, JOSEPH DANIEL (contact)

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Adoption;adverse outcome;aggregation database;Algorithms;Architecture;Artificial Intelligence;Basic Science;Benchmarking;Bioinformatics;Biological;Biological Assay;biomedical data science;Cataloging;Chemicals;Clinical;clinical effect;clinical predictors;Communities;Complex;Computational Technique;computational toxicology;Computer software;Computing Methodologies;computing resources;cost;Data;Data Analyses;data infrastructure;data resource;Data Scientist;data standards;Databases;design;Development;diverse data;Ecosystem;Emerging Technologies;Ensure;environmental toxicology;Evaluation;Expert Systems;Explosion;Exposure to;Genes;Genetic Programming;Goals;Graph;graph database;hands-on learning;Human body;improved;Informatics;informatics tool;innovation;Institution;interest;Kinesiology;Knowledge;knowledge graph;knowledge translation;Learning;learning strategy;Libraries;Link;Machine Learning;Mentors;method development;Methodology;Methods;Modeling;Modernization;multimodal data;multiple omics;Names;network architecture;neural network architecture;new technology;Ontology;open data;Outcome;Outcomes Research;Output;Paper;Pathway interactions;Pattern;Phase;Process;Productivity;Protocols documentation;Quantitative Structure-Activity Relationship;real world application;Reporting;Research;Research Personnel;Resources;response;Risk;Risk Assessment;Semantics;side effect;Signal Transduction;small molecule;Source;Statistical Models;Structure;success;Techniques;Technology;tool;Toxic effect;toxicant;Toxicant exposure;Toxicology;Translation Process;Translational Research;trend analysis;Validation;Work;Xenobiotics

PROJECT_TITLE: Discovering clinical endpoints of toxicity via graph machine learning and semantic data analysis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Allorecognition and altruism are important abilities in biomedicine and social evolution, and the intersection between them has been described as a greenbeard system. Dictyostelium discoideum is one of the best model systems for studies in this field and our recent findings show that it employs a bona fide greenbeard mechanism that confers the ability to display and recognize a kinship signal and to act altruistically toward related individuals. We will study how altruism is executed, how cheaters and falsebeards are avoided, and how these processes can change the way we think about interactions between social organisms, cells within multicellular organisms, and some of the microbial parasites that infect and harm humans.

PI_NAMEs: SHAULSKY, GAD  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Mechanistic analysis of a pathway that integrates allorecognition and altruism in Dictyostelium

STUDY_SECTION: MRAD

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - D Study Section[MRAD]


ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Selective autophagy pathways use receptors to fragment and load membrane domains into autophagosomes that are targeted for degradation. Our studies are focused on understanding how endoplasmic reticulum (ER)- Golgi trafficking machinery and lipid droplets mediate these events during ER autophagy. This work is likely to advance our understanding of quality control in the ER and will have significant medical implications for the study of diabetes and other metabolic disorders.

PI_NAMEs: FERRO-NOVICK, SUSAN  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Autophagocytosis;Autophagosome;Binding;Biochemical;Biogenesis;Biological Assay;Cells;Complex;Cytoplasm;Defect;Diabetes Mellitus;Endoplasmic Reticulum;Event;Family member;Genetic;Goals;Golgi Apparatus;Guanosine Triphosphate Phosphohydrolases;Human;In Vitro;in vitro Assay;Lipids;Lysosomes;Mammals;Mediating;Medical;Membrane;Membrane Proteins;Metabolic Diseases;misfolded protein;monolayer;multicatalytic endopeptidase complex;novel;Obesity;Organelles;Pathway interactions;Phenotype;Phospholipids;Proteins;Quality Control;receptor;Role;seal;Sorting;sterol ester;trafficking;Vacuole;Variant;Vesicle;Work;Yeasts

PROJECT_TITLE: The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality control

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Integrating cryo-EM techniques into the P450 field will open new horizons in understanding molecular dynamics and evolution (with the prospect of rational reprogramming) of this catalyst, including its interactions with the electron donor partner proteins and biological membranes. For CYP51 in particular, such knowledge is essential in developing new therapeutics that benefit human health, in addressing the escalating problem of drug resistance in the clinic and will help validate the proximal P450 surface as a new target for inhibition.

PI_NAMEs: LEPESHEVA, GALINA I (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Address;Allosteric Regulation;Amoeba genus;Bacteria;Biochemistry;Biological;Catalysis;catalyst;Chimeric Proteins;Clinic;comparative;Cryoelectron Microscopy;Crystallography;Cytochrome P450;Cytoplasmic Protein;Drug Design;Drug Kinetics;Drug resistance;electron donor;Electron Transport;emerging pathogen;Endoplasmic Reticulum;Enzymes;Eukaryota;Family;Ferredoxin;fungus;Genes;Goals;Health;Human;Hydroxylation;inhibitor;insight;Knowledge;Leishmania;Life;Mediating;Membrane;Molecular;Molecular Biology;Molecular Conformation;molecular dynamics;Molecular Evolution;molecular recognition;Mycoses;NADPH-Ferrihemoprotein Reductase;novel therapeutics;Organism;Orthologous Gene;Pharmaceutical Preparations;Phylogeny;Physiological;Planet Earth;Plants;pollutant;preference;progenitor;programs;Proteins;Protozoa;Reaction;Research;Roentgen Rays;Role;Set protein;small molecule libraries;Specificity;Steroids;Sterol Biosynthesis Pathway;Sterols;structural biology;Structure;Surface;System;targeted treatment;Techniques;Trypanosoma;Variant;Vertebrates;Vitamins;Work;Xenobiotics

PROJECT_TITLE: Structural requirements for sterol 14α-demethylases

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Networking and Information Technology R&D (NITRD);Physical Activity;Physical Rehabilitation;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Patients with a condition called ischemia with no obstructive coronary artery disease (INOCA) have symptoms including chest pain, fatigue, and depression, and there are currently few effective treatment options. Cardiac rehabilitation, which is an organized way to deliver exercise and lifestyle counseling, has the potential to work for these patients but there are many factors that can make participation difficult (for example, if there are no facilities nearby). Our study will test whether a new platform for cardiac rehabilitation, delivered by an electronic tablet device paired with weekly remote counseling (known as mobile health cardiac rehabilitation), will improve how INOCA patients feel after 3, 6, and 12 months.

PI_NAMEs: DODSON, JOHN A;REYNOLDS, HARMONY R. (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Atherosclerosis;Birth;Cardiac rehabilitation;Cardiovascular Diseases;caregiving;Caring;Chest Pain;Clinical;cohort;Coronary;Coronary Arteriosclerosis;Coronary heart disease;cost;Counseling;debilitating symptom;depressive symptoms;design;Deterioration;Disease;Disparity;Documentation;Dyspnea;Education;effective therapy;efficacy evaluation;Electronics;Emotional;Enrollment;EuroQOL;Evaluation;Exercise;experience;Face;Fatigue;Feeling;Female;Gender;Goals;Health;Health Status;Healthcare;Heart Diseases;Heart failure;High Prevalence;Home;Image;Impaired health;improved;improved outcome;Individual;Intervention;intervention effect;Ischemia;Life Style;male;Measures;Mediating;men;Mental Depression;mHealth;mhealth interventions;Modification;novel;Outcome;Participant;Patient Participation;Patients;persistent symptom;Persons;Pharmaceutical Preparations;Phase;Physical activity;physical conditioning;Physicians;portability;pragmatic randomized trial;Prevalence;primary endpoint;programs;Proliferating;prospective;Provider;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;remote monitoring;Reporting;revascularization;routine practice;Scientist;secondary endpoint;sex;sex as a biological variable;Sex Differences;Site;social culture;Social support;Stress Tests;Symptom Burden;symptomatic improvement;Symptoms;Tablet Computer;Technology;telecoaching;Testing;Transportation;treatment as usual;Uninsured Medical Expense;uptake;Woman;Women's Health;Women's prevalence;Work

PROJECT_TITLE: mHealth-CArdiac REhabilitation for INOCA (INOCA-CARE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (52)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Complex neurodevelopmental disorders (NDDs) are characterized by cognitive impairment, maladaptive behaviors, and disrupted sensory processing, though it remains unclear how these distinct manifestations are mechanistically (neurobiologically) related. Using animal models of causal NDD genetic risk, this project will define how cortical circuitry required for sensory processing causes cognitive impairment that leads to maladaptive behaviors.

PI_NAMEs: MILLER, COURTNEY A;RUMBAUGH, GAVIN R (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adaptive Behaviors;Animal Model;Area;Arousal;Attention deficit hyperactivity disorder;autism spectrum disorder;Basic Science;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Brain;brain cell;Budgets;Cell Physiology;Cells;Clinical;Cognitive;cognitive function;Complex;Consensus;Data;Decision Making;design;Detection;Etiology;excitatory neuron;experience;Functional disorder;gene discovery;Genes;Genetic Risk;genetic risk factor;genome sequencing;hindbrain;Impaired cognition;Impairment;insight;Learning;Link;locus ceruleus structure;maladaptive behavior;Measurement;Measures;Mediating;Mental disorders;Modeling;Molecular;mouse model;Mus;neural;Neurobiology;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel;patient population;Patients;Perception;Process;Property;Prosencephalon;Psychological reinforcement;Publishing;Research;Rest;risk variant;Schizophrenia;Sensory;sensory cortex;Sensory Process;Signal Transduction;social;Somatosensory Cortex;spatiotemporal;Surface;Synapses;Synaptic plasticity;SYNGAP1;System;Tactile;Testing;Touch sensation;Translating;Vibrissae

PROJECT_TITLE: Intersection of causal neurodevelopmental disorder risk genes, cortical circuit function, and cognitive processing required for behavioral adaptions


ADMINISTERING_IC: CA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: Project Narrative Liver cancer is a deadly form of malignancy with limited treatment options. This project seeks to understand how different mutations in Wnt/β-Catenin pathway contribute to liver cancer development. The results will elucidate the distinct signaling pathways induced by β-catenin activation due to distinct mechanisms; and will pave a way for precision medicine for liver cancer treatment.

PI_NAMEs: CHEN, XIN  (contact);MONGA, SATDARSHAN SINGH

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Adverse effects;AXIN1 gene;AXIN1 protein;beta catenin;Biological;cancer therapy;Cells;Classification;Collaborations;CTNNB1 gene;Development;Disease;Disparate;Enterobacteria phage P1 Cre recombinase;Event;Exons;FDA approved;gain of function;gain of function mutation;Gene Expression;Genes;Genetic Variation;Glucose;Glutamate-Ammonia Ligase;Glutamine;Hepatocarcinogenesis;hepatocellular carcinoma cell line;Human;Immune checkpoint inhibitor;Impairment;In Vitro;inhibitor;Injections;Isotope Labeling;Lead;Ligands;Liver;liver cancer model;loss of function;loss of function mutation;LoxP-flanked allele;Malignant neoplasm of liver;Malignant Neoplasms;Metabolic;Metabolism;Minor;Modeling;Molecular;molecular subtypes;molecular targeted therapies;mouse model;Mus;mutant;Mutation;Oncogenic;overexpression;Pathogenesis;Pathway interactions;Placebos;Play;Porcupines;Pre-Clinical Model;precision medicine;Primary carcinoma of the liver cells;Productivity;receptor;response;Role;Sampling;Scaffolding Protein;Signal Pathway;Signal Transduction;Sleeping Beauty;Tail;Tankyrase;Testing;Therapeutic;Transposase;tumor;Universities;Unresectable;Veins

PROJECT_TITLE: Investigating multifactorial beta-catenin activation in hepatocellular cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-J(05)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Functional genomic technologies have been developed primary in cultured cells making it difficult to address the complex phenotypes, such as spatial-temporal, and tissue/cell type specificity and interactions that occur in organisms. In this proposal, I will combine zygote manipulation methods and functional genomics technologies to develop novel high-throughput assays in mice, including MPRA and large-scale CRISPR saturation mutagenesis. The novel in vivo high-throughput technologies that I will develop in my training phase will enable to study in mice regulatory elements and disease-associated variants at developmental time points and tissues in my independent stage.

PI_NAMEs: USHIKI, AKI  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Address;ATAC-seq;base editor;Biological Assay;Brain;career;Catalogs;cell type;Cells;ChIP-seq;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Color;Complex;CRISPR screen;Cultured Cells;Data;Dependovirus;Development;Disease;DNA;DNA Sequence;DNA Transposable Elements;ds-DNA;Ectoderm;Electroporation;Elements;Embryo;Endoderm;Enhancers;Ensure;extracellular;Female;functional genomics;Future;gain of function;gastrulation;gene function;Genes;Genetic Enhancer Element;Genome;genome wide association study;genome-wide;genomic data;genomic tools;Genomics;Germ Layers;Glycoproteins;Goals;Guide RNA;Heart;Heterozygote;high throughput screening;high throughput technology;human disease;Human Genome;In Vitro;in vivo;Individual;Knock-out;Lead;Libraries;Liver;loss of function;Mammalian Oviducts;Measures;Mentors;Mesoderm;Methods;Mus;Mutagenesis;Mutation;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Organism;Penetration;Phase;Phenotype;pregnant;prevent;prime editor;promoter;Publications;Regulatory Element;Reporter;Reporting;Research;Research Personnel;Satellite Viruses;screening;Serotyping;Single Nucleotide Polymorphism;Specificity;System;Techniques;Technology;Testing;Thick;Time;Tissues;tool;Training;Transgenic Mice;Transposase;Untranslated RNA;Variant;Zona Pellucida;zygote

PROJECT_TITLE: Development of functional genomic technologies in mice

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Clinical Research;Lung;Prevention;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Acute respiratory distress syndrome is an acute onset respiratory failure that affects more than 200,000 people a year United States and is treated with mechanical ventilation which, in turn, causes ventilator-induced lung injury (VILI) that is one of the primary drivers of the 40% ARDS mortality rate. However, determining the mechanical ventilation settings that minimize VILI, and improve ARDS outcomes, for each patient is difficult because individual lung physiology and ventilation requirements are different. To overcome this challenge, we will develop a mechanical ventilation system that uses mathematical models to predict and apply the optimal ventilation pattern to minimizes VILI for each patient and improve ARDS survival.

PI_NAMEs: SMITH, BRADFORD J (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Affect;Algorithms;Alveolar;Alveolus;Animal Model;atelectrauma;Biochemical;Biological Markers;Blood capillaries;Caring;Clinical;Complex;Computer Models;Conflict (Psychology);cost;COVID-19;Data;Death Rate;experience;Feedback;Functional disorder;Future;Gases;Heterogeneity;Hospital Mortality;Hospitals;Human Resources;improved;in silico;Individual;Inflammation;Inflammatory;Injury;innovation;Lung;Lung Compliance;lung injury;Manuals;mathematical model;Measurement;Measures;mechanical force;Mechanical ventilation;Mechanics;Modeling;Monitor;mortality;Mus;Outcome;pandemic disease;Pathogenesis;patient population;patient variability;Patients;Pattern;Periodicity;personalized approach;Persons;pharmacologic;Phenotype;Physiology;Pneumonia;prediction algorithm;predictive modeling;pressure;prevent;Process;prospective;Protocols documentation;Provider;Pulmonary Edema;pulmonary function;real time model;research clinical testing;Resources;respiratory;Respiratory Failure;response;Risk;Risk Factors;Rodent;Safety;Sepsis;simulation;skills;Stretching;Structure;surfactant;System;temporal measurement;Testing;Thinness;Time;Tissues;tool;Training;Trauma;United States;ventilation;Ventilator;Ventilator-induced lung injury;Volutrauma;Workload

PROJECT_TITLE: Predicting and Preventing Ventilator-Induced Lung Injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Data Science;Digestive Diseases;Food Allergies;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE  As a debilitating disease, eosinophilic esophagitis (EoE) affects 1 in 2000 individuals in the United States. We will use Raman spectroscopy and machine learning to define esophageal biochemical composition in EoE. This would add to our understanding of the pathobiology of EoE and promote personalized care of EoE patients.

PI_NAMEs: HIREMATH, GIRISH  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Affect;Allergens;Allergic inflammation;Award;Biochemical;Bioinformatics;Biometry;Biophotonics;Biopsy;career;Career Choice;career development;Characteristics;chemical fingerprinting;Child;Childhood;Chronic;Clinical;clinical care;clinical translation;Clinical Trials;clinically relevant;comparison control;Data;Data Analytics;Data Science;Deglutition;Development;Development Plans;Dimensions;Disease;disease phenotype;Endoscopy;eosinophil;Eosinophilic Esophagitis;Eosinophilic Gastrointestinal Disease;Epithelium;Esophageal Tissue;Esophagus;experience;feeding;Food;Future;Gastroenterologist;gastrointestinal;Glycogen;Goals;Grant;healing;Histologic;Histology;indexing;Individual;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;inhibitor therapy;insight;Knowledge;Lasers;Lead;Leadership;Libraries;Lipids;Machine Learning;machine learning algorithm;Mediating;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Pathogenesis;Pathology;patient oriented research;Patients;personalized approach;personalized care;Positioning Attribute;precision medicine;predicting response;Prediction of Response to Therapy;Program Development;programs;Prospective Studies;Proteins;Proton Pump Inhibitors;Publications;Publishing;Pump;Raman Spectrum Analysis;Research;Research Personnel;Role;Severities;skill acquisition;skills;success;supportive environment;System;Techniques;Testing;Therapeutic;Time;tissue injury;Tissues;Topical Corticosteroids;Translational Research;treatment response;United States;Universities;Variant;Work;Writing

PROJECT_TITLE: Precision Medicine Approaches for Eosinophilic Esophagitis Using Raman Spectroscopy and Machine Learning

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Project Narrative This research will test the potential to repurpose a small molecule BRAF kinase inhibitor, dabrafenib, an FDA- approved drug for several cancers, for new use in preventing cisplatin- induced hearing loss. Significant protection against cisplatin-induced hearing loss has been achieved with oral delivery of dabrafenib in mouse models in doses approved in humans. The successful completion of this study will provide the crucial data needed for rapidly advancing dabrafenib to clinical studies in humans for prevention of hearing loss.

PI_NAMEs: TEITZ, TAL  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Affect;Aging;Anti-Inflammatory Agents;Antibiotic Therapy;Antioxidants;Auditory;Benchmarking;Biological;Biological Assay;Biological Availability;Biological Markers;BRAF gene;Cancer Patient;cancer therapy;Cell Death;Cell Death Induction;Cell Line;Cell Physiology;Cells;Cessation of life;chemotherapy;Cisplatin;cisplatin induced hearing loss;Clinic;Clinical;Clinical Research;Clinical Trials;Cochlea;conditional knockout;Data;Dexamethasone;Dose;drug repurposing;ebselen;effectiveness testing;experimental study;FDA approved;Genetic;Goals;Hair Cells;hearing impairment;high throughput screening;Human;in vivo;inhibitor;Inner Supporting Cell;kinase inhibitor;Knockout Mice;Labyrinth;lateral line;Lethal Dose 50;Malignant neoplasm of lung;Malignant Neoplasms;MAP2K1 gene;MAPK3 gene;Medical;Melanoma;Methionine;Modeling;Molecular;Molecular Target;Morphology;mouse model;Mus;Neuroblastoma;neuromast;Noise;noise exposure;Noise-Induced Hearing Loss;Non-Small-Cell Lung Carcinoma;Oral;otoprotectant;ototoxicity;Outer Hair Cells;Pathway interactions;Patients;Performance;Persons;Phalanx;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phosphorylation;postnatal;pre-clinical;prevent;prevent hearing loss;Prevention;Property;Protein Kinase;Proto-Oncogene Proteins B-raf;Protocols documentation;Publishing;Raf Kinase Inhibitor;Regimen;Research;Resistance;Role;Route;Signal Transduction;small cell lung carcinoma;small molecule;small molecule inhibitor;sodium thiosulfate;standard care;standard of care;Stress;Supporting Cell;Testing;Therapeutic;Therapeutic Index;therapeutic target;Time;Toxic effect;Translations;tumor;Tumor Cell Line;Up-Regulation;Work;Zebrafish

PROJECT_TITLE: Repurposing an FDA approved Drug, B-Raf Kinase Inhibitor Dabrafenib for Protection from Cisplatin- and Noise- induced Hearing Loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Obesity and diabetes are predisposing factors for vascular dysfunction that precedes the development of cardiovascular disease. The mechanisms behind vascular dysfunction in obese, diabetic individuals are not entirely understood. Thus, in the current study, we are investigating the crosstalk between the adipose tissue and endothelial cells as an underlying mechanism for vascular dysfunction and also as a target for non- pharmacological therapeutic interventions such as aerobic exercise and weight loss.

PI_NAMEs: MOHAMED, ABEER M (contact)

PROGRAM_OFFICER_NAME: SCHUM, PAULA

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Aerobic Exercise;Affect;angiogenesis;arteriole;atherogenesis;bariatric surgery;Biological;Biopsy;Blood Vessels;Body Weight decreased;Cardiovascular Diseases;cardiovascular risk factor;Caveolae;Cell membrane;Cell surface;Cells;Ceramides;Characteristics;Chemicals;Communication;comorbidity;Cytoprotection;Data;Development;Diabetes Mellitus;diabetic;effectiveness testing;Endothelial Cells;endothelial dysfunction;Endothelium;Event;Exercise;exercise training;extracellular vesicles;Glucose;Glycosphingolipids;glycosylation;Goals;Homeostasis;Human;Hyperglycemia;Hypoxia;improved;In Vitro;Individual;Inflammation;Insulin Resistance;intercellular communication;lipid metabolism;Lipids;Measures;Mediating;Mediator;Membrane;Metabolic;MicroRNAs;mimetics;Molecular;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;Obesity;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;Permeability;Phosphorylation;Physical activity;preconditioning;Predisposing Factor;prevent;Process;Production;Property;Proteins;Randomized;Research;Risk;Role;Sampling;sensor;shear stress;Signal Transduction;social;src-Family Kinases;Structure;subcutaneous;Surface;synergism;Testing;Therapeutic;Therapeutic Intervention;Thinness;Tissues;transcytosis;uptake;Vascular Diseases;vascular endothelial dysfunction;Visceral;weight loss intervention

PROJECT_TITLE: Role of Adiposomes in Diabetes-Associated Endothelial Dysfunction and Restorative Effects of Exercise and Metabolic Surgery

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE The long-term objective of the ongoing research proposal is to understand the functional consequences of the myosin binding protein-C closely-related family of proteins on heart function in health and heart failure. In particular, the proposed studies will determine the specific role(s) of the fast myosin binding protein-C protein, a member of the family recently shown to be increased expression in the heart failure. More specifically, we will investigate the impact of fast myosin binding protein-C on sarcomere structure and function and heart contractility in the setting of heart failure.

PI_NAMEs: SADAYAPPAN, SAKTHIVEL  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Ablation;Actomyosin;Adrenergic Agents;Adult;Age;Age Months;aorta constriction;Aortic coarctation;Attenuated;Biochemical;Biophysics;Body Weight;C2 Domain;Cardiac;Cardiac Myocytes;Cardiac Myosins;Chimera organism;citrate carrier;Clinical;clinical care;comparison control;Complex;Defect;Development;Ensure;Etiology;Exhibits;experimental study;Familial Hypertrophic Cardiomyopathy;Family member;Filament;Fluorescence;Foundations;Functional disorder;Generations;Genes;genetic regulatory protein;Goals;Grant;Health;Heart;Heart Contractilities;Heart failure;heart function;Heart Hypertrophy;Impairment;improved;In Vitro;Knock-in Mouse;Knock-out;Knockout Mice;Maps;Mediating;Microfilaments;Molecular;mortality;mouse model;Mus;Muscle function;Mutation;Myocardial dysfunction;Myocardium;Myopathy;Myosin ATPase;myosin-binding protein C;new therapeutic target;novel;Organ;paralogous gene;Pathway interactions;Pilot Projects;pre-clinical;pressure;prevent;Protein Family;Protein Isoforms;Proteins;recombinant adenovirus;Recombinant Proteins;Regulation;Relaxation;Reporter;Research Proposals;Role;Sarcomeres;sex;Skeletal Muscle;Structure;Syndrome;Testing;therapeutic target;Thick Filament;Thin Filament;Tissues;Transgenic Mice;Transgenic Organisms;Up-Regulation;Weight;Work

PROJECT_TITLE: Fast myosin binding protein-C and cardiac contractility in heart failure

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Pain Research;Patient Safety;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: SURGERY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Recovery from thoracic surgery (used to treat common chronic lung conditions) is associated with serious complications which may be prevented if more effective early detection and management strategies existed. Based on evidence from improved outcomes in oncology, electronic systems for monitoring patient-reported outcomes (ePROs), which are symptoms reported directly from the patient, are one potential solution. This application proposes to bridge the gap in knowledge on the optimal ePRO system design, how to use ePROs in surgery, and the benefits of ePROs in surgery using rigorous implementation science approaches.

PI_NAMEs: MODY, GITA NATWAR (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Address;Adoption;Area;Award;Awareness;Biometry;Cancer Patient;career;Caring;Cessation of life;Chest;Chronic;Clinic;Clinic Visits;Clinical;clinical center;Clinical effectiveness;Clinical Trials;Colorectal Surgery;Complex;Complication;Computer software;Consolidated Framework for Implementation Research;Coupled;COVID-19;Data;Data Analyses;Data Sources;Death Rate;Dedications;design;Dyspnea;Early Diagnosis;Effectiveness;effectiveness outcome;electronic patient reported outcomes;Electronics;Eligibility Determination;Emergency department visit;Enrollment;Ensure;Environment;Excision;Feedback;Frequencies;Future;Goals;health care service utilization;health data;health information technology;Health Services Research;high risk;Home;hospital readmission;implementation barriers;implementation evaluation;implementation fidelity;implementation framework;implementation outcomes;implementation science;implementation/effectiveness;improved;improved outcome;Individual;International;Intervention;Interview;K-Series Research Career Programs;Knowledge;Lung;Lung Diseases;Measurement;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;Monitor;mortality;National Heart, Lung, and Blood Institute;North Carolina;novel;Nurse Practitioners;Oncology;Operative Surgical Procedures;Outcome Measure;Outcomes Research;Pain;participant enrollment;Patient Monitoring System;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Population;Positioning Attribute;Postoperative Care;Postoperative Period;practice factors;prevent;Prospective Studies;Protocols documentation;Provider;Qualitative Research;Quality of life;randomized trial;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;real world application;Recovery;remote monitoring;Repeat Surgery;Reporting;Research;Research Infrastructure;Research Methodology;Resources;respiratory;response;Risk;Role;routine care;Schedule;Scientist;skills;Structure;success;Surgeon;surgery outcome;surgical risk;Surveys;symptom management;Symptoms;System;Testing;Thoracic Surgeon;Thoracic Surgical Procedures;Time;Training;Universities;Use Effectiveness;virtual healthcare;Work

PROJECT_TITLE: Improving Thoracic Surgical Care using electronic Patient-Reported Outcomes (ePROs)

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Diabetes;Genetics

PHR: PROJECT NARRATIVE. Insulin-producing pancreatic β cells play a central role in maintenance of whole-body glucose homeostasis. The proposed studies will examine the role of the key islet-enriched transcription factor NKX2.2 as a regulator of adult human β cell function and provide insight into molecular mechanisms mediating its impact on insulin secretion. To that end, these studies will further our understanding of human β cell biology, with broader implications for new therapeutic strategies for diabetes.

PI_NAMEs: PETTWAY, YASMINYE D (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adult;Alpha Cell;anterior chamber;ATAC-seq;base;Beta Cell;Biology;blood glucose regulation;career;career development;Cell Nucleus;Cell Physiology;Cell Separation;Cellular biology;Chromatin;Chronic;Collaborations;Communication;Communities;CRISPR/Cas technology;D Cells;Development;Diabetes Mellitus;diabetes pathogenesis;differential expression;DNA Binding;endocrine pancreas development;endoplasmic reticulum stress;Environment;Event;eye chamber;Fellowship;Foundations;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profiling;gene function;gene repression;Genes;Genetic;Genetic Transcription;Harvest;homeodomain;Homeodomain Proteins;Hormones;Human;human tissue;Immunodeficient Mouse;improved;In Vitro;in vivo;innovation;insight;Insulin;insulin regulation;insulin secretion;interest;islet;Islet Cell;Islets of Langerhans;knock-down;Knock-out;Leadership;live cell imaging;loss of function;Maintenance;Mediating;Microfluidics;Molecular;mouse model;multiple omics;Mus;Mutation;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Paracrine Communication;Pathway interactions;Patients;Phenotype;Physicians;Play;Proteins;Research;Research Personnel;Role;Scientist;Signal Transduction;single nucleus RNA-sequencing;skills;Structure of beta Cell of islet;Testing;Tissue-Specific Gene Expression;Training;Transcript;Transcription Coactivator;transcription factor;Transcription Repressor;Transcriptional Regulation;transcriptome;Transplantation;United States National Institutes of Health

PROJECT_TITLE: Molecular mechanisms of NKX2.2 function in adult human beta cells


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Infectious Diseases;Lung;Rare Diseases;Regenerative Medicine;Sepsis

PHR: NARRATIVE A major complication of a bacterial infection in the bloodstream is the excessive activation of the immune system, which then attacks the body’s own tissues and organs, which can result in a patient’s death even if am infection is treated with antibiotics. We believe that one important reason for this severe immune response is the injury of blood vessel cells which immune cells. The research in this proposal will help us reduce the death of blood vessel cells to prevent the excessive immune response and hopefully lead to treatments for patients suffering from severe infections.

PI_NAMEs: REHMAN, JALEES  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Address;Amplifiers;Anti-Inflammatory Agents;Antibiotics;Bacteria;Bacterial DNA;Bacterial Infections;Binding;Blood Circulation;Blood Vessels;Caspase;Cell Death;Cell membrane;cell regeneration;Cell Survival;Cells;Cessation of life;Complication;cytokine;Cytosol;Data;Disease Progression;DNA;DNA Damage;Electrophysiology (science);Endothelial Cells;endothelial regeneration;Endothelium;Endotoxemia;fighting;Genetic;Host Defense;Hypoxemia;Image;Immune;immune activation;Immune response;Immune system;improved;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injury;Interferon Type I;Interleukin-1 beta;Intervention;intravital imaging;Ion Channel;Ions;Knock-out;Lead;Lipopolysaccharides;LoxP-flanked allele;Lung;Lung Capacity;lung failure;lung imaging;lung injury;lung vascular injury;Macrophage;Mediating;microvesicles;Mitochondria;Mitochondrial DNA;mitochondrial membrane;Modeling;Molecular;mortality;mouse model;Multiple Organ Failure;N-terminal;Natural regeneration;neutrophil;novel;novel therapeutic intervention;Organ;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;perforin;Physiological;polymicrobial sepsis;prevent;programs;Proteins;Regenerative capacity;reparative capacity;Research;response;Role;Sepsis;Severities;Signal Pathway;Signal Transduction;Stimulator of Interferon Genes;System;Testing;Tissues;two-photon;Vascular Endothelium;viral DNA

PROJECT_TITLE: Amplification Mechanisms of Lung Endothelial Inflammation During Acute Lung Injury


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project narrative In this project we will develop predictive fitness model that accurately accounts for immune recognition of influenza antigens and for the epidemiological factors that create the environment for the evolution of the virus, to quantify fitness effects that are imposed on the virus. Using machine learning approaches we will leverage large sequence and phenotypic datasets to propose objective criteria for the influenza vaccine strain selection.

PI_NAMEs: LUKSZA, MARTA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: acquired immunity;Algorithms;Antigenic Diversity;Antigens;B-Lymphocytes;Biological Assay;biophysical model;Biophysics;Cancer Patient;CD8-Positive T-Lymphocytes;cohort;Collaborations;Computer Models;Data;Data Set;Databases;Environment;epidemiologic data;Epidemiologic Factors;Epitopes;Evolution;Ferrets;fitness;Flu virus;Future;Genetic;Genetic Variation;geographic population;Goals;Herd Immunity;Human;Immune;Immune response;Immune system;Immunity;Immunodominant Antigens;immunogenicity;Immunological Models;Infection;Influenza;influenza surveillance;influenza virus vaccine;influenzavirus;Ions;Joints;Machine Learning;machine learning prediction;Maps;Modeling;multiple datasets;Mutation;Nature;New York City;novel;Pattern;phenotypic data;Phylogeny;Population;Population Dynamics;predictive modeling;pressure;Process;Proteins;Publishing;reconstruction;Research Personnel;response;seasonal influenza;Seasons;Serology;Serology test;Shapes;Source;ST14 gene;Statistical Models;Structure;System;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;transmission process;Vaccination;vaccine efficacy;vaccine-induced immunity;Vaccines;Viral;Virus;virus genetics;whole genome;Work

PROJECT_TITLE: Predictive fitness models for influenza vaccine strain selection


NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Lizards and salamanders both regenerate their tails, but the regenerated lizard tail lacks a skeleton with the segmentation and ossification characteristics of the salamander regenerate. This proposal employs an integrated approach to identify the regulatory networks underlying these differences, which will be used to guide manipulations of the regenerated lizard tail to phenocopy the more complex salamander tails. The knowledge gained here should provide important insights into approaches to improve vertebrate regenerative outcomes.

PI_NAMEs: LOZITO, THOMAS PETER (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;Amaze;Ambystoma;Ambystoma mexicanum;Anatomy;Apoptosis;asexual;blastema;bone cell;Cartilage;cartilage development;cartilage regeneration;cartilaginous;Cell Lineage;Cell Survival;Cells;cellular engineering;Characteristics;Chemotaxis;Chondrocytes;comparative;Complex;CXCR4 gene;CXCR4 Receptors;design;Development;Disparity;Elements;Embryo;Environment;Epiphysial cartilage;Exhibits;Funding;Generations;Goals;healing;Homologous Transplantation;Human;Hypertrophy;Immunosuppression;improved;in vivo;innovation;insight;Interruption;Intervention;knock-down;Knowledge;Ligands;Lizards;Mammals;Medicine;Meningeal;Meninges;migration;model organism;Molecular;Natural regeneration;notochord;novel;Operative Surgical Procedures;Organism;Osteoblasts;Outcome;parathyroid hormone-related protein;Pattern;Periosteum;Phenocopy;Physiologic Ossification;Population;Process;recruit;regenerative;Regenerative capacity;Regenerative Medicine;Research Project Grants;Role;Salamander;Signal Induction;Signal Transduction;skeletal;Skeletal Development;skeletal maturation;skeletal regeneration;skeletal tissue;Skeleton;Source;spatiotemporal;Spinal Cord;Tail;Testing;Thyroid Hormones;Tissue Engineering;tissue regeneration;Tissues;Translating;Tube;ubiquitin-protein ligase;Vertebral column;wound environment;wound healing

PROJECT_TITLE: Why don’t lizards regenerate perfect tails like salamanders?

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE In psychiatric disorders characterized by severe stress and anxiety, memories of safety are more difficult to learn and remember than memories of threat, perhaps explaining relapse after therapy. The proposed research uses multivariate pattern analysis of neuroimaging data to localize the neural representation of threat and safety memories in the human brain. This research could lay the theoretical groundwork for more effective clinical treatments for anxiety and stress-related disorders.

PI_NAMEs: DUNSMOOR, JOSEPH EDWARD (contact)

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Adult;Affect;American;Amygdaloid structure;Animal Experimentation;Animal Model;Animals;Anxiety;Anxiety Disorders;anxiety treatment;Arousal;Association Learning;Award;Behavior;Behavioral;Brain;Brain region;Categories;Clinical;Clinical Research;Clinical Treatment;Code;conditioned fear;conditioning;Data;Deterioration;diagnostic criteria;Dorsal;Emotional;endophenotype;Episodic memory;Event;Exposure to;Extinction;Failure;fear memory;Feeling;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Hippocampus;Hour;Human;human model;Hybrids;Image;improved;Individual;Information Retrieval;innovation;insight;Knowledge;Learning;learning extinction;Link;Measurable;member;Memory;memory encoding;memory recognition;memory retrieval;Mental disorders;Mental Health;Modeling;Motivation;neural;neuroimaging;neurophysiology;Neurosciences;novel;Outcome;Pathogenesis;Pathological anxiety;Pathology;Patients;Pattern;Phase;Physiological;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Prevalence;Psychiatric therapeutic procedure;Recovery;Relapse;Research;resilience factor;response;Retrieval;Risk Factors;Rodent;Safety;Semantics;Series;Site;standard care;Stress;stress disorder;stress related disorder;Symptoms;Techniques;Testing;Time;Training;Translating;Visual;Work

PROJECT_TITLE: Localizing and modulating competing memories of fear and safety in the human brain

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Transcranial Magnetic Stimulation (TMS) is a widely used technology for non-invasive modulation of human brain activity with demonstrated efficacy in treatment of major depressive disorder. Accurate quantitative targeting and dosing of TMS requires anatomically detailed models for estimating the induced intracranial electric fields (E-fields) but currently no technique exists that has the computational efficiency to enable “online” neuronavigation applications while at the same time incorporating high level of anatomical detail with the necessary numerical accuracy. To remove this efficiency vs. accuracy dilemma that is currently posing a critical barrier for development of more quantitative TMS approaches, we propose to utilize our recently developed Boundary Element Method (BEM) based computational strategy accelerated by the Fast Multipole Method (FMM) to develop a near-real time high-resolution computational TMS neuronavigation system.

PI_NAMEs: NUMMENMAA, AAPO  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: 3-Dimensional;Acceleration;Anatomy;Applications Grants;Area;automated segmentation;Benchmarking;Boundary Elements;Brain;Clinical;clinical application;clinical effect;Clinical Research;commercial application;Computing Methodologies;cortex mapping;cranium;Data;Development;Dose;electric field;Electromagnetics;Electromyography;Functional Magnetic Resonance Imaging;Generations;Geometry;Goals;gray matter;Head;healthy volunteer;Hot Spot;Human;Human Volunteers;improved;Individual;Individual Differences;innovation;Location;magnetic field;Magnetic Resonance Imaging;Major Depressive Disorder;Manufacturer;Maps;Measures;Memory;Methods;Modeling;Motor;National Institute of Mental Health;Neuronavigation;Neurosciences Research;neurosurgery;novel;operation;Optics;Patient Schedules;Patients;Performance;Peripheral;physical model;Physiologic pulse;Positioning Attribute;Prefrontal Cortex;prototype;Publishing;Real-Time Systems;repetitive transcranial magnetic stimulation;Research;Resolution;response;Scalp structure;Skin;Source;Specific qualifier value;Speed;Surface;System;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Transcranial magnetic stimulation;translational potential;treatment-resistant depression;volunteer;white matter

PROJECT_TITLE: Near real-time system for high-resolution computationalTMS navigation


ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: A population of Phox2b-expressing excitatory neurons in the retrotrapezoid nucleus (RTN) of the ventral medulla oblongata provide a CO2/H+-chemosensory and integrative role in regulating breathing; dysfunction of this neuronal system is implicated in potentially fatal syndromes (e.g., sudden infant death, congenital central hypoventilation) and re-setting of CO2 threshold/sensitivity can accompany and exacerbate various chronic disorders of breathing (e.g., chronic obstructive pulmonary disease). The cellular and molecular mechanisms that regulate pH sensitivity, and developmental or adaptive changes in those neurons have not been determined. Using mouse genetic models or viral transduction, the proposed work will incorporate single cell electrophysiological and molecular characterization of RTN neurons to uncover receptor and channel mechanisms of pH sensitivity, and to provide a transcriptome-wide examination of phenotypic features that support breathing in the vulnerable perinatal period or sustain function throughout life in the face of environmental or pathological challenge.

PI_NAMEs: BAYLISS, DOUGLAS A. (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Ablation;Acids;Acute;Address;Air;Apnea;Arousal;base;behavioral study;Birth;Blood gas;Brain Stem;Breathing;Candidate Disease Gene;Carbon Dioxide;Cell Nucleus;Cells;Central Sleep Apnea;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;congenital central hypoventilation syndrome;Control Locus;CRISPR/Cas technology;critical period;Data;Detection;Development;Electrophysiology (science);Epitopes;excitatory neuron;experimental study;Functional disorder;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic analysis;genetic manipulation;Genetic Models;GPR4 gene;Hypoventilation;In Vitro;in vivo;Knock-in Mouse;Legal patent;Life;Measures;Mediating;Medulla Oblongata;Molecular;Molecular Profiling;mouse genetics;Mus;mutant;Mutate;neonatal period;Neuroanatomy;neuronal cell body;Neuronal Dysfunction;neuronal excitability;Neurons;Neuropeptides;new therapeutic target;novel;Pathologic;Pattern;perinatal period;Phenotype;Physiological;pituitary adenylate cyclase activating polypeptide;Pontine structure;Population;postnatal;Potassium Channel;premature;Process;protein expression;Protons;Proxy;receptor;Regulation;Respiration;Respiration Disorders;respiratory;response;restoration;Role;sensor;Sensory;sensory mechanism;single-cell RNA sequencing;Site;Sudden infant death syndrome;Syndrome;System;Techniques;Testing;Time;Tissues;transcription factor;transcriptome;transcriptomics;Viral;Work

PROJECT_TITLE: Cellular/Molecular Mechanisms of Respiratory Neuronal Chemosensitivity

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Hearing disorders such as tinnitus, presbycusis, and noise-induced hearing loss are incredibly common and have long been recognized as public health epidemics. This project employs novel strategies to identify how feedback loops between high and low-level auditory centers contribute to hearing, which could eventually inspire new treatments for hearing disorders. More broadly, similar feedback loops occur across all sensory systems; these studies thus lay the conceptual groundwork to understand a general principle of mammalian sensory perception and higher-order brain function.

PI_NAMEs: APOSTOLIDES, PIERRE F (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Active Listening;Address;Anatomy;Anesthesia procedures;Animals;Apical;Auditory;Auditory area;auditory discrimination;auditory pathway;auditory processing;Auditory system;awake;Behavioral;Behavioral Assay;Biophysical Process;Brain;Brain Stem;Cognition;Cognitive;Complex;Data;Dendrites;Detection;Discrimination;discrimination task;Epidemic;Event;experience;experimental study;Feedback;Frequencies;Generations;Glutamates;Goals;Head;Hearing;hearing impairment;Hearing problem;Image;improved;In Vitro;Inferior Colliculus;Knowledge;Learning;Light;Linguistics;Link;Mediating;Midbrain structure;Mus;neuronal cell body;Neurons;Noise-Induced Hearing Loss;novel strategies;operation;optogenetics;Outcome;Output;Pathway interactions;Perception;Perceptual learning;physical property;Play;Presbycusis;prevent;Public Health;Quality of life;Rewards;Role;segregation;Sensory;sensory system;Shapes;Signal Transduction;sound;Speech;Stimulus;Stream;Synapses;Testing;Time;Tinnitus;transmission process;two-photon;Work

PROJECT_TITLE: Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway


PHR: Project Narrative The proposed studies address an important and under-investigated area of childhood developmental stuttering pertaining to neural oscillatory synchrony underlying auditory-motor integration that supports speech perception and production. Using a multimodal imaging approach that combines both EEG and MRI data, the results of the proposed studies are expected to clarify for the first time the temporal dynamics of neural connectivity that are affected in children with persistent stuttering. These studies are expected to guide future intervention development that targets enhancing auditory-motor integration through manipulation of neural synchrony.

PI_NAMEs: CHANG, SOO-EUN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Adult;Affect;Area;Auditory;Auditory Perception;Auditory system;Bilateral;Brain;Brain region;Cephalic;Characteristics;Child;Child Development;Childhood;Childhood Stuttering;clinical diagnosis;Clinical Treatment;Communication;Complex;Corpus striatum structure;Data;Data Collection;Development;Developmental Stuttering;Disease;early childhood;Early Intervention;Exhibits;Foundations;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;imaging approach;innovation;Intervention;magnetic resonance imaging/electroencephalography;Mental Health;Motor;Motor Activity;Motor Cortex;Movement;Multimodal Imaging;neural;Neurobiology;neuromechanism;Neurons;Neurosciences;noninvasive brain stimulation;novel;Occupational Health;Outcome;Participant;Pattern;peer;Periodicity;Persons;Phase;Physiological;Production;Research Design;response;Role;Sensory;sensory stimulus;Series;Speech;Speech Perception;speech processing;Structure;Stuttering;System;Techniques;Testing;therapy development;therapy outcome;Time;verbal;Work

PROJECT_TITLE: Neural oscillations underlying speech perception and production in childhood stuttering

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ROYAL OAK

ORG_NAME: WILLIAM BEAUMONT HOSPITAL RESEARCH INST

PHR: Project Narrative Glioblastoma continues to be a uniformly fatal malignancy despite aggressive therapy. The proposed studies are designed to understand how altered lipid metabolism discovered in glioblastoma contributes towards its aggressive phenotype in an effort to identify novel treatment combinations for this aggressive form of cancer.

PI_NAMEs: CHINNAIYAN, PRAKASH  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acylation;aggressive therapy;Automobile Driving;beta-Hydroxybutyrate;cancer therapy;Cell Death;Cell Proliferation;Cells;Chemicals;Clinical;clinically relevant;combinatorial;Combined Modality Therapy;Complex;Coupling;Cues;Data;deprivation;design;Development;DNA Sequence Alteration;Ecology;Energy-Generating Resources;Enzymes;Event;fatty acid metabolism;fatty acid-transport protein;Fatty Acids;Genetic Transcription;Genomics;Glioblastoma;Gliomagenesis;Glucose;Glycolysis;Heterogeneity;Histone Deacetylase Inhibitor;in vivo;Investigation;Laboratory Study;Link;lipid metabolism;Malignant Neoplasms;Mediator;Mesenchymal;Mesenchymal Differentiation;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;Methods;Modeling;Molecular;Mutation;new therapeutic target;novel;novel therapeutics;Nutrient;Nutrient availability;Patients;Phenotype;Play;Pre-Clinical Model;Process;programs;Proliferating;PTEN gene;Receptor Protein-Tyrosine Kinases;Research Design;Resistance;Role;Secondary to;Series;Source;Stress;Testing;Therapeutic;Toxic effect;translational potential;treatment strategy;tumor;tumor metabolism;tumor microenvironment;uptake

PROJECT_TITLE: Developing therapeutic strategies to elicit metabolic synthetic lethality in glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE Influenza A virus (IAV) is a major respiratory pathogen causing both annual epidemics and sporadic pandemics in the human population that result in significant morbidity and mortality across people of all ages. Tethered mucin 1 (MUC1) is expressed on multiple cell types that influence IAV infection (e.g. airway epithelial cells; macrophages) and has the potential to impact pathogenesis through physical interactions and/or signaling activity. Our interrogation of IAV infection in novel in vitro and in vivo models with altered MUC1 expression will advance our understanding of mucin biology, reveal how IAV negotiates MUC1 to efficiently infect the respiratory tract, and thereby evaluate MUC1 as a potential therapeutic target during infection.

PI_NAMEs: SCULL, MARGARET ADELE (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: acute infection;Address;Affect;Age;airway epithelium;Amino Acids;Apical;Atlases;Bacterial Infections;Binding;Biological Assay;Biological Models;Biology;Bone Marrow;Cell Compartmentation;Cell Culture Techniques;Cell surface;cell type;Cells;Cellular Structures;Clinical;Consensus;Cytoplasmic Tail;Data;defined contribution;Disease;Epidemic;Epithelial Cells;Flow Cytometry;Gel;Glycoproteins;glycosylation;Goals;Hematopoietic;Human;Immune response;Immunohistochemistry;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;Influenza A virus;influenzavirus;innovation;insight;Interferons;Investigation;Kinetics;Knockout Mice;Laboratories;Lung;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediation;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucin 1 protein;Mucins;Mucous body substance;Mus;Nature;novel;Outcome;pandemic disease;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Penetration;Persons;Phosphorylation;Physiological;Population;posttranscriptional;preference;Proteins;Public Health;Reporting;Research;respiratory pathogen;Respiratory System;Role;Sialic Acids;Signal Transduction;Signaling Molecule;Stable Isotope Labeling;Surface;System;Technology;Testing;therapeutic target;Time;Tracheal Epithelium;tumor progression;Tumor Promotion;Up-Regulation;uptake;Viral;Viral Pathogenesis;Virus Diseases;Virus Replication

PROJECT_TITLE: Molecular Mechanisms and In Vivo Impact of Tethered Mucin 1-Influenza Virus Interactions

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Infectious Diseases;Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE COVID-19 has been associated with high in-hospital morbidity and mortality, although longer-term outcomes in patients surviving to hospital discharge remain unclear. This study aims to investigate the prevalence of albuminuria and other markers of kidney injury and inflammation at 3 months following hospital discharge, and to evaluate kidney function decline in patients with COVID-19 post-discharge up to 24 months.

PI_NAMEs: MENEZ, STEVEN  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;adjudication;Admission activity;Albuminuria;analytical method;APOL1 gene;Award;Biological Markers;Blood;career;CCL2 gene;Clinical;cohort;Complication;Computerized Medical Record;Country;COVID-19;COVID-19 diagnosis;COVID-19 disparity;COVID-19 impact;COVID-19 patient;COVID-19 survivors;Creatinine;Data;Diagnosis;Doctor of Philosophy;epidemiology study;Evaluation;Event;experience;Five-Year Plans;follow-up;Foundations;functional decline;Funding;Goals;Health;Health system;High Prevalence;high risk;Hospital Mortality;Hospitalization;Hospitals;IL18 gene;IL8 gene;Incidence;Inflammation;Inflammatory;Injury;Injury to Kidney;insight;Institution;instructor;Interleukin-1 beta;Interleukin-10;Interleukin-2;Interleukin-4;Interleukin-6;Investigation;Kidney;Knowledge;LCN2 gene;Letters;Measurement;Measures;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;multiplex assay;Natural History;Nature;Nephrology;novel coronavirus;Outcome;pandemic disease;Patients;Pattern;Persons;Phenotype;Physicians;Premature Mortality;Prevalence;prevent;Process;professor;Prognosis;Protocols documentation;Public Health Schools;Race;Recording of previous events;recruit;Registries;Renal function;Research;Research Design;Research Personnel;Research Project Grants;research study;risk variant;Sampling;SARS-CoV-2 infection;Scientist;Serum;sex;Survivors;Time;TNF gene;Training;Training and Education;Translational Research;Tubular formation;UMOD gene;Universities;Urine;Viral;Work

PROJECT_TITLE: Epidemiologic and Translational Investigation of Long-Term Kidney Outcomes After COVID-19

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: PROJECT NARRATIVE Aberrant behaviors of neural stem and progenitor cells (NSPC) during brain development can lead to cortical malformations, such as microcephaly and macrocephaly, as well as various neurodevelopmental disorders. Knowledge about precise control of NSPC behaviors is essential to dissecting the underlying pathogenic mechanisms. Our proposed studies will provide novel insights to how a selective RNA decay mechanism can influence NSPC behaviors and to the etiology of microcephaly.

PI_NAMEs: ZHENG, SIKA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Ablation;Affect;Behavior;Biochemical;Biology;Brain;cell behavior;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell determination;Cell Lineage;cell type;Cells;Characteristics;Collaborations;Computational Biology;conditional knockout;Cortical Malformation;Data;daughter cell;Defect;Development;developmental neurobiology;Ensure;Equilibrium;Etiology;Genes;Genetic;Genetic Transcription;In Vitro;in vivo;insight;Knock-out;Knockout Mice;Knowledge;Length;Link;Macrocephaly;Measures;Mediating;Messenger RNA;Methods;Microcephaly;Molecular;Mothers;mouse genetics;mRNA Decay;mRNA Stability;Mutation;Neocortex;nerve stem cell;nestin protein;neural;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroglia;Neurons;neuroregulation;Neurosciences;Nonsense Codon;Normal Cell;novel;Output;Pathogenicity;Pathway interactions;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;postmitotic;posttranscriptional;Process;progenitor;Proliferating;Radial;Recording of previous events;Regulation;Regulatory Pathway;Reporting;RNA;RNA chemical synthesis;RNA Decay;RNA Degradation;RNA Processing;Role;Shapes;spatiotemporal;stem;stem cell differentiation;stem cells;Testing;Time;tool;TP53 gene;Transcript;transcription factor;transcriptomics

PROJECT_TITLE: The Role of NMD in Cortical Neural Progenitor Cells

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Migraine;Neurosciences;Pain Research;Racial and Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: MOORE, CARLENE D (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Address;Affect;Afferent Neurons;African American;African American population;Amplifiers;Animal Behavior;Animal Model;Applications Grants;Area;Attenuated;Basic Science;Biological;Biological Assay;career;career development;Caucasians;Cell Degranulation;Cell Line;Cell Lineage;Cells;Cholic Acids;Coculture Techniques;Collaborations;Communication;Complex;Dermatology;Development;Development Plans;Dinoprostone;Discipline;Dose;Environment;experience;experimental study;Exposure to;face skin;Functional disorder;Future;Gene Targeting;Genes;Goals;Head;Headache;Human;IL6 gene;Immunology;in vivo;Inflammation;Inflammatory;inflammatory pain;inhibitor;interdisciplinary approach;Ion Channel;keratinocyte;Laboratories;Leadership;loss of function;Lysophosphatidylcholines;Maps;mast cell;Measures;Mediator;Medicine;Melanins;Meningeal;Meninges;Mentors;Migraine;Molecular;Mus;Nervous System Disorder;Neuroglia;Neurology;neuronal excitability;Neurons;Nociception;Nociceptors;Pain;pain signal;paracrine;Pathologic;Pathway interactions;peer networks;Permeability;personalized medicine;Phosphotransferases;Physiological Processes;Pigmentation physiologic function;Play;Positioning Attribute;precursor cell;Principal Investigator;Process;Race;racial difference;Racial Segregation;receptor;Regulation;Research;Research Personnel;response;Role;Severities;Signal Transduction;skills;Skin;Skin Pigmentation;spelling;Statistical Data Interpretation;supportive environment;Techniques;Testing;Time;tissue injury;TNF gene;Topical application;Training;Translational Research;Trigeminal Pain;Trigeminal System;Ultraviolet B Radiation;Universities;UVB induced;Writing

PROJECT_TITLE: Molecular and Cellular signaling mechanisms of TRPV4 in non-neuronal cells: a pathophysiological relevance for migraine pain.


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Narrative Plasmodium vivax is the major cause of non-African malaria and a significant problem for global health, with an estimated burden $1.4 - $4 billion per year. There is a critical need for a vaccine against P. vivax because of its relapsing nature and limited treatment options to clear dormant liver stages. The goal of this project is to develop a multivalent vaccine to prevent infection from mosquito transmission.

PI_NAMEs: ADAMS, JOHN H (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Africa;Aliquot;Animals;Antibodies;Antibody Response;Antibody titer measurement;Antigen Targeting;Antigen-Presenting Cells;Antigens;Binding;Binding Proteins;Biological Assay;Blood;breakthrough infection;candidate validation;cell type;Cells;Clinical;Collaborations;cost estimate;Country;Cryopreservation;Culicidae;design;Development;Ensure;Epitope Mapping;Epitopes;Erythrocytes;experimental study;Formulation;Future;Geographic Locations;global health;Goals;Growth;Healthcare;Hepatocyte;Human;Immune;Immune response;Immune Sera;Immunity;Immunization;Immunize;Immunoassay;immunogenicity;Immunologics;immunoreactivity;In Vitro;in vitro Assay;Individual;Infection;Infection prevention;Laboratories;Laboratory Animals;Limited Stage;Liver;Malaria;Malaria Vaccines;Maps;Methods;migration;Modeling;Monoclonal Antibodies;Mus;Myanmar;nanoparticle;Nature;Parasites;Parasitic infection;Persons;Peru;Plasmodium falciparum;Plasmodium vivax;prevent;Process;Productivity;Property;protective efficacy;Recombinants;Relapse;Risk;RNA;RNA vaccine;Seasons;Source;Sporozoites;Subunit Vaccines;Thailand;Transgenic Organisms;transmission process;transmission-blocking vaccine;uptake;Vaccination;Vaccine Antigen;vaccine candidate;vaccine delivery;Vaccine Design;vaccine development;vaccine strategy;Vaccines;vaccinology;Validation;Vivax Malaria;Work

PROJECT_TITLE: Accelerating discovery of an efficacious Plasmodium vivax multivalent multi-stage vaccine


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Ovarian Cancer;Patient Safety;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: We have developed a new transvaginal imaging device that uses a co-registered photoacoustic and ultrasound technique for more accurate ovarian cancer diagnosis. In this project, the new imaging device will be optimized and prospectively evaluated by a team of radiologists to determine if the device can improve the current clinical practice by more accurately diagnosing ovarian cancers and reducing unnecessary benign surgeries. The new imaging device will also be used to screen a small group of women who have increased risk of ovarian cancer to determine its effectiveness on early ovarian cancer detection.

PI_NAMEs: POWELL, MATTHEW A;SIEGEL, CARY L;ZHU, QUING  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: absorption;accurate diagnosis;Acoustics;advanced disease;Algorithms;angiogenesis;Benign;Biological Markers;CA-125 Antigen;Cancer Detection;cancer diagnosis;cancer risk;Cessation of life;chemotherapy;Classification;clinical practice;Compensation;cost;Data;Development;Devices;Diagnosis;Disease;Doppler Ultrasound;Early Diagnosis;Effectiveness;Emerging Technologies;Epithelial ovarian cancer;Fatality rate;Functional Imaging;Growth;Hemoglobin;high risk population;High Risk Woman;Image;imaging biomarker;Imaging Device;imaging modality;Imaging technology;improved;Incidence;interest;Lasers;Lesion;Light;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Measures;Modality;Modeling;Monitor;Morbidity - disease rate;non-invasive imaging;noninvasive diagnosis;Operative Surgical Procedures;Optics;optoacoustic tomography;Ovarian;Ovarian Mass;Ovarian Tissue;Ovariectomy;Ovary;Oxygen;Patients;Pelvic Examination;Penetration;photoacoustic imaging;Physiologic pulse;Positron-Emission Tomography;predictive modeling;Predictive Value;Process;prospective;radiologist;Resolution;Risk;Risk Management;Role;screening;Screening for Ovarian Cancer;Screening procedure;Serum;standard of care;Stromal Neoplasm;Survival Rate;System;Techniques;Testing;Time;Tissue Sample;Tracer;Transvaginal Ultrasound;treatment response;tumor;Tumor Angiogenesis;tumor hypoxia;tumor metabolism;Tumor Oxygenation;Ultrasonic Transducer;Ultrasonography;ultrasound;uncertain malignant potential neoplasm;Unnecessary Surgery;Vagina;vascular factor;Woman;Women's Group;Work;X-Ray Computed Tomography

PROJECT_TITLE: Coregistered Photoacoustic and Ultrasound Imaging for Ovarian Cancer Diagnosis and Risk Management

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative This proposal focuses on the underlying causes of aspirin exacerbated respiratory disease (AERD), a severe form of asthma and sinus disease. The results of these studies will aid in understanding the underlying causes of AERD and should point the way to new therapies.

PI_NAMEs: BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Affinity;Agonist;airway inflammation;Alveolar;antagonist;Antibodies;Arachidonate 5-Lipoxygenase;Arachidonic Acids;Aspirin;aspirin-exacerbated respiratory disease;Asthma;asthma exacerbation;autocrine;base;Binding;Biology;Blood Platelets;Blood Vessels;Bronchoconstriction;cell type;Cells;cellular targeting;chronic rhinosinusitis;Clinical;cysteinyl leukotriene receptor;cysteinyl leukotriene receptor 2;cysteinyl-leukotriene;desensitization;Dinoprostone;Disease;DNA-Binding Proteins;Drug Targeting;Eicosanoids;Event;Extravasation;Functional disorder;G-Protein-Coupled Receptors;Genetic;HMGB1 gene;Human;human subject;Hypersensitivity;Immunologics;immunopathology;in vivo;Inflammation;innovation;insight;Interleukins;Leukotriene C4;Leukotriene D4;leukotriene-C4 synthase;Ligand Binding;lipid mediator;Lung;Lymphoid Cell;mast cell;Mediating;Mediator;Microsomes;Modeling;Molecular;Mus;Myeloid Cells;Nose;novel;novel therapeutics;Parents;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Physiological;Physiology;Platelet Activation;Play;polyposis;preference;prevent;programs;Property;Prostaglandins;Reaction;receptor;receptor expression;receptor for advanced glycation endproducts;Receptor Signaling;recruit;Refractory;Regulation;respiratory;respiratory smooth muscle;Respiratory System;response;Role;Signal Transduction;Sinus;Site;Syndrome;Testing;Therapeutic;therapeutic development;therapeutic target;Tissues;tool;Transgenic Mice;translational potential

PROJECT_TITLE: Eicosanoid Networks in Aspirin Hypersensitivity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(57)]


ORG_CITY: ALBANY

ORG_NAME: ALBANY MEDICAL COLLEGE

PHR: We are proposing a to study how mechanical stimuli can stimulate myelination and improve peripheral nerve regeneration after injury. If our working model is validated, this proposal will define the importance of mechanobiology in peripheral nerves and may reveal novel therapeutic targets for myelin diseases and for peripheral nerve regeneration.

PI_NAMEs: POITELON, YANNICK  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Affect;Agonist;Axon;axon injury;Cations;Cell Differentiation process;Cell Physiology;Cells;Chemicals;Clinical Treatment;Cytoskeleton;Data;design;Development;Disease;DNA-Binding Proteins;Economic Burden;Elasticity;Extracellular Matrix;Fiber;Funding;Gene Expression;Gene Expression Regulation;Genes;Genets;Growth;Health;Impairment;improved;In Vitro;in vivo;Injury;Ion Channel;knock-down;Knock-out;Knockout Mice;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Modeling;Molecular;mouse model;Myelin;myelination;nervous system development;Neuroglia;Neuropathy;new therapeutic target;novel;Pathway interactions;Peripheral nerve injury;peripheral nerve regeneration;peripheral nerve repair;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Physiologic pulse;Piezo 1 ion channel;Public Health;Radial;regeneration potential;Regulation;remyelination;Research;response;Role;Schwann Cells;sensor;Signal Transduction;small hairpin RNA;social;Stimulus;Structure;Symptoms;Testing;Therapeutic;Therapeutic Effect;Tissues;transcription factor;Transducers;Trauma;Ultrasonic wave;ultrasound;Variant

PROJECT_TITLE: Transduction of Mechanical Stimuli in Myelination and Peripheral Nerve Repair


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Physical activity is a key protective factor for reducing risk for chronic diseases and all-cause mortality, yet only 35% of African American women meet national physical activity guidelines. Community settings hold tremendous promise as an important context for reaching African American women, but we argue that previous community- based interventions have focused on a relatively narrow scope of social-environmental variables. Addressing social affiliation needs is a critical next step for improving the impact of community-based physical activity interventions for inactive African American women and reducing existing health inequities.

PI_NAMEs: SWEENEY, ALLISON MARIE (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Address;Adult;African American;African American Women;Belief;Blood Pressure;Body mass index;Cardiovascular Diseases;Cessation of life;Chronic Disease;cohesion;cohort;Communities;community center;community intervention;community setting;cultural values;Data;design;Disparity;effective intervention;efficacy evaluation;Elements;exercise intervention;experience;Feeling;follow-up;Goals;Guidelines;Health behavior change;health inequalities;Health Promotion;improved;Individual;innovation;Intervention;intervention effect;Intervention Studies;Interview;life span;Light;Maintenance;Mediating;Mediator;meetings;member;moderate-to-vigorous physical activity;mortality;Motivation;novel;Outcome;Participant;peer;Physical activity;Play;post intervention;premature;Process;process evaluation;programs;protective factors;Randomized;Recommendation;Research;Risk Reduction;Role;secondary outcome;sedentary lifestyle;Self Determination;Self Efficacy;social;social cognitive theory;social culture;social learning;South Carolina;theories;therapy design;White Women

PROJECT_TITLE: The Together Everyone Achieves More Physical Activity Trial (TEAM-PA)

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative  Gene therapies for genetic disorders of the central nervous system have rapidly advanced to the clinic with promising outcomes, and in several instances adeno-associated virus (AAV) serotype 9 has been used given its ability to transduce large numbers of neurons throughout the CNS. We recently discovered that the AAV9 capsid interacts with constitutive promoters to dramatically alter the pattern of CNS cellular gene expression. Determining the basis for this AAV9 capsid-promoter interaction will prove highly important to the design of future studies for CNS gene therapy.

PI_NAMEs: MCCOWN, THOMAS J. (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: adeno-associated viral vector;Alanine;Amino Acids;Back;Capsid;Cell Nucleus;Cells;cellular transduction;Cellular Tropism;Central Nervous System Diseases;Chimera organism;Clinic;Clinical;clinical translation;Clinical Trials;Complement;Confocal Microscopy;Corpus striatum structure;Dependovirus;design;Elements;Enhancers;Exhibits;Future;Gene Expression;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;giant axonal neuropathy;Glutamates;Immunohistochemistry;In Vitro;in vivo;Introns;Length;Location;Manuscripts;Minor;Modification;Molecular Conformation;Mutagenesis;mutant;Nature;Neurons;nonhuman primate;novel;Oligodendroglia;Outcome;Pattern;promoter;Property;Publishing;Rattus;receptor binding;RNA Splicing;Role;Serotyping;Site;Spinal Muscular Atrophy;success;Techniques;Therapeutic;trafficking;Transgenes;Translating;Tropism;vector;Virus Diseases

PROJECT_TITLE: AAV capsid-promoter interactions determines CNS cell selective gene expression in vivo

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative SRGAP2C is a human-specific gene that regulates neuronal circuit architecture, but it remains unknown how it impacts the functional properties of neuronal circuits. Using a multimodal in vivo imaging approach, this proposal aims to uncover how SRGAP2C controls neuronal circuit function, and consequently affects cognition and behavior. Results obtained in this study will provide novel insights into the role human-specific genes such as SRGAP2C modify the functional properties of cortical circuits, and ultimately provide insight into how these genes may contribute to the pathophysiology of neuropsychiatric and neurodevelopmental disorders in humans.

PI_NAMEs: SCHMIDT, EWOUD  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Architecture;Behavior;Behavioral;Behavioral Paradigm;Brain;brain behavior;Brain region;career;career development;Cellular Neurobiology;Cognition;cognitive function;Communities;Data;density;Development;Development Plans;discrimination task;Doctor of Philosophy;Environment;Equipment;Evolution;Feedback;Functional disorder;Gene Expression;Genes;Genetic;Goals;GTPase-Activating Proteins;Human;Image;imaging approach;Imaging Techniques;in vivo;in vivo imaging;insight;interest;International;Laboratories;Learning;Maps;Mediating;Mentors;Microscopy;Mind;Molecular;Molecular Neurobiology;multimodality;Mus;Mutation;Neocortex;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;neuronal patterning;Neurons;neuropsychiatric disorder;Neurosciences;novel;Optics;optogenetics;paralogous gene;Pathology;Pattern;Perceptual learning;Performance;Play;Property;Research;Research Project Grants;Resources;response;Rest;Role;Sensory;sensory discrimination;sensory stimulus;Shapes;Structure;success;Synapses;Techniques;Testing;Time;Training;trait;two photon microscopy;Universities;unpublished works;Work

PROJECT_TITLE: The Role of Human SRGAP2C in Regulating Neuronal Circuit Function and Behavior

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]