NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infectious Diseases;Infertility;Maternal Health;Pediatric;Pregnancy;Women's Health Research

PHR: PROJECT NARRATIVE Spontaneous pregnancy loss is a devastating and serious public health problem affecting 1 in 4 women worldwide. While uterine infection is associated with pregnancy loss, how infectious triggers impact endometrial function is unknown. The proposed research will determine the mechanisms by which bacterial and viral components impact endometrial inflammation, decidualization, and communication with placental trophoblasts, contributing to our current understanding of the pathophysiology of early pregnancy loss in women who have been exposed to infection.

PI_NAMEs: TONG, MANCY  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acceleration;adverse pregnancy outcome;Advisory Committees;Affect;Bacterial Infections;Bioinformatics;Biology;Cell Aging;Cell Communication;Cell Differentiation process;Cell Physiology;chemokine;Coculture Techniques;Communication;cytokine;Data;Decidual Cell Reactions;desensitization;Double-Stranded RNA;early pregnancy loss;Endometrial;Endometrial Stromal Cell;Endometrium;Escherichia coli;experience;Exposure to;extracellular vesicles;failure Implantation;Family;fetal;First Pregnancy Trimester;Functional disorder;Growth;healthy pregnancy;IL8 gene;immune function;Immunology;immunoregulation;Impairment;implantation;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interferon Type I;Invaded;Knowledge;Learning Skill;Link;Lipopolysaccharides;Maternal-Fetal Exchange;Mediating;medical schools;Mentors;Mentorship;Microbe;migration;mouse model;novel;obstetrical complication;Phase;Placenta;Placental Biology;placental trophoblasts;Placentation;Play;Poly I-C;post-doctoral training;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy loss;Pregnancy Outcome;premature;Premature Birth;Process;Production;Progesterone;Public Health;Receptor Signaling;Regulatory Pathway;Research;response;Risk;senescence;Series;Signal Pathway;Signal Transduction;Simplexvirus;success;Testing;Therapeutic;three-dimensional modeling;Toll-like receptors;Training;transcriptome sequencing;trophoblast;Uterus;Viral;Virus Diseases;Woman;Work

PROJECT_TITLE: Mechanisms of Endometrial Innate Immune Responses to Infection and Impact on Placental Interactions


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Infant Mortality;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The public health relevance of this study relates to the persistent problem of undernutrition among very preterm infants (those born <32 weeks of gestation) receiving neonatal intensive care. By creating a new fetal reference for body composition and identifying targets for fat-free mass accretion based on neurodevelopmental outcomes, this project will inform new and more effective strategies for assessing and monitoring the nutritional status of very preterm infants. The overall goal is for pragmatic nutrition-based interventions within neonatal intensive care that support optimal long-term health and neurodevelopmental outcomes for the ~63,000 very preterm infants born each year in the U.S. and many more worldwide.

PI_NAMEs: BELFORT, MANDY BROWN (contact);RAMEL, SARA E

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Address;Affect;Age;Air;Auditory;behavior measurement;Biolectric Impedance;Biometry;Birth;Body Composition;Body measure procedure;Brain;brain health;Brain Injuries;brain magnetic resonance imaging;brain size;Clinical;clinical application;clinical care;clinical practice;cohort;Cohort Studies;Collaborations;critical period;Data;Development;Diet;Dietary intake;Dietary Intervention;early detection biomarkers;Electroencephalography;Epidemiology;Equation;Equipment;Event-Related Potentials;evidence base;extreme prematurity;Fatty acid glycerol esters;fetal;Foundations;Gestational Age;Goals;Growth;Health;Hospitalization;Impairment;improved;improved outcome;Individual;Infant;innovation;Intervention;Knowledge;Length;magnetic resonance imaging/electroencephalography;Malnutrition;Measurement;Measures;Micronutrients;Monitor;Morbidity - disease rate;Neonatal Intensive Care;Neonatal Intensive Care Units;Neonatology;neurodevelopment;Neurodevelopmental Impairment;Neurosciences;Nutrient;nutrition;Nutrition Assessment;Nutritional;Nutritional status;Nutritional Study;Nutritional Support;Organ;Outcome;Participant;Performance;Plethysmography;Population;Pregnancy;Premature Infant;Proteins;public health relevance;Publishing;randomized trial;Recovery;recruit;Research Infrastructure;Research Personnel;Resources;respiratory;response;Rest;Sampling;Site;Specificity;Structure;Techniques;Time;Tissues;Translating;virtual;Vulnerable Populations;Weight Gain;Work

PROJECT_TITLE: Development of a brain-specific nutritional status indicator for very preterm infants


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Narrative This is a multidisciplinary, highly collaborative consortium that combines next- generation sequencing with state- of- the- art behavioral screening in a unique, genetically diverse, nonhuman animal model. The goals of this consortium are to identify gene variants that are associated with compulsive-like cocaine intake and behavioral endophenotypes using genome- wide association studies (GWAS) in behaviorally characterized heterogeneous stock rats, and to strengthen the infrastructure of a newly created data/tissue repository (Cocaine Biobank) accessible to all researchers to study the cellular and molecular mechanisms related to cocaine use disorder. Results from these studies have the potential to have a sustained and powerful impact on the field of addiction because they will identify novel druggable targets, provide a comprehensive analysis of cocaine addiction-like behaviors in males and females, and increase the impact of a unique data/tissue repository that will facilitate follow- up and replication studies.

PI_NAMEs: GEORGE, OLIVIER  (contact);PALMER, ABRAHAM A

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Alcohol abuse;Animal Genetics;Animal Model;Animals;Behavior;Behavioral;behavioral phenotyping;biobank;Biological;Brain;Brain region;Chronic;Cocaine;Cocaine Dependence;cocaine exposure;cocaine self-administration;cocaine use;Cocaine use disorder;Code;Collaborations;Communities;comorbidity;Complex;Computer software;Computerized Medical Record;Data;data integration;deep neural network;Documentation;endophenotype;Environment;Epigenetic Process;Female;follow-up;Foundations;Gene Expression;Genetic;genetic analysis;genetic variant;genome sequencing;genome wide association study;genomic locus;Genomics;Genotype;Goals;Heritability;Human;Human Genome;improved;Incidence;Individual;Infrastructure;Intake;Intravenous;Investigation;Lead;longitudinal analysis;Machine Learning;male;Maps;Methodology;Modeling;Molecular;multidisciplinary;multiple omics;National Institute of Drug Abuse;new therapeutic target;next generation;next generation sequencing;nicotine abuse;novel;novel strategies;Nucleotides;Outcome;Phenotype;Physiology;Population;pre-clinical;Procedures;programs;Quantitative Trait Loci;Rattus;Research;Research Personnel;Resistance;Resources;Sample Size;Sampling;screening;screening program;Self Administration;Standardization;Substance abuse problem;Substance Addiction;substance use;Substance Use Disorder;Tandem Repeat Sequences;Technology;Tissue Banks;Tissues;trait;transfer learning;United States National Institutes of Health;Variant;Video Recording

PROJECT_TITLE: Identification of Genetic Variants that Contribute to Compulsive Cocaine Intakein Rats


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PI_NAMEs: LAFLEUR, BONNIE  (contact)

PROJECT_TERMS: Aging;analytical method;Area;biobank;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;Biometry;brain health;Classification;Code;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collaborations;collaboratory;community engagement;computer infrastructure;computer program;Custom;dashboard;Data;Data Aggregation;Data Analyses;Data Collection;data integration;data management;data reduction;Data Science Core;Data Set;data sharing;Data Storage and Retrieval;data visualization;Databases;design;Ensure;experience;Formulation;Foundations;Funding;Genomics;Goals;Good Clinical Practice;healthspan;Heterogeneity;Human;Image;Individual;Informatics;Knowledge;large scale data;life span;Link;Literature;Machine Learning;machine learning method;Manuscripts;member;Methods;Modality;Modeling;Molecular Profiling;Monitor;multimodality;neuroimaging;novel;open data;Participant;precision medicine;predictive modeling;Procedures;Public Domains;Publications;Publishing;PubMed;recruit;Reporting;repository;Reproducibility;Research;Research Project Grants;Risk;Sample Size;Science;Scientist;Secure;Site;statistical and machine learning;Statistical Data Interpretation;System;Technology;terabyte;Testing;text searching;Theoretical model;Time;tool;Update;Visual;Work

PROJECT_TITLE: Data Science (DS) Core B


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Biotechnology;Brain Disorders;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative ARHI, a complex trait, is the most common cause of hearing loss and is one of the most prevalent conditions affecting the elderly globally. Estimates suggest approximately two-thirds of people over the age of 70 in the United States experience ARHL,1 and that by 2020, over half of all people in the United States with hearing loss will be over 70 years of age. We are proposing to identify candidate genes by performing the first genome- wide association study (GWAS) of ARHI in mice and examining gene expression in the inner ear for sceQTL and network studies.

PI_NAMEs: FRIEDMAN, RICK A (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: 1 year old;Affect;Age;Age Years;Aging;Auditory;Auditory Brainstem Responses;Auditory system;Biological Models;Candidate Disease Gene;candidate identification;Chromatin;Chromosome Mapping;Cochlea;Cochlear Implants;cohort;Complex;cost;Data;deafness;Dementia;differential expression;drug development;Economic Burden;Elderly;Epithelial Cells;Epithelium;experience;Family Study;Farm;Female;Follow-Up Studies;forward genetics;functional genomics;Gene Expression;Gene Expression Profiling;Genes;Genetic;genetic analysis;genetic approach;Genetic Recombination;genetic risk factor;Genetic Variation;Genome;genome wide association study;Genotype;Goals;Health Expenditures;Hearing;Hearing Aids;hearing impairment;hereditary hearing loss;Heredity;Heritability;Homologous Gene;Housing;Human;Human Genome;human subject;Impaired cognition;improved;Inbred Strains Mice;interest;Investments;Labyrinth;Loneliness;male;Maps;Measures;Mental Depression;model organism;Molecular;mouse model;Mus;Mutation;Nature;new therapeutic target;novel;Organism;otoacoustic emission;Pathway interactions;Patients;Persons;Phenotype;phenotypic data;Physiology;Polygenic Traits;Population;Presbycusis;prevent;Prevention;progressive hearing loss;Quantitative Trait Loci;Random Allocation;Research;Resolution;Resources;Risk;risk variant;Severities;Single Nucleotide Polymorphism;Standardization;Structure;targeted treatment;therapeutic development;Therapeutic Intervention;Tissues;trait;transcriptome sequencing;Twin Studies;Ultrafine;United States;Variant;XCL1 gene

PROJECT_TITLE: The genetic basis for age-related hearing loss in outbred mice

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CLEVELAND

ORG_DEPT: CHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Synthetic DNA-based nanoparticles possess the potential to develop advanced delivery tools for targeted therapies, but their behavior in the cytosolic environment remains poorly understood. Herein, we seek to address critical issues about the accessibility and breakdown of these nanoparticles within the mammalian cell cytosol and identify mechanisms of stabilization. Outcomes of the proposed project will enable the realization of more- biocompatible delivery systems.

PI_NAMEs: MATHUR, DIVITA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Address;Animal Model;Architecture;Award;Behavior;Biological Models;Biological Sciences;biomaterial compatibility;Biomedical Engineering;Buffers;Calcium;Cancerous;Cell Culture Techniques;Cell Nucleus;cell type;Cells;Confocal Microscopy;CRISPR/Cas technology;Cytosol;cytotoxic;delivery vehicle;Dictyoptera;DNA;Dose;Drug Carriers;Endocytosis;Endosomes;Engineering;Environment;Family suidae;Fibroblasts;Fluorescence Resonance Energy Transfer;Gene Silencing;gene therapy;Genes;Goals;Grant;Hypoxia;Immune;improved;In Vitro;in vitro Model;in vivo Model;innovative technologies;Kinetics;Learning;Ligands;Lysosomes;Mammalian Cell;Maps;Measures;Mentorship;Messenger RNA;Microinjections;Mus;nanoparticle;Nanotubes;National Institute of Biomedical Imaging and Bioengineering;neoplastic cell;nuclease;nucleic acid-based therapeutics;Nucleic Acids;Outcome;particle;pharmacologic;physical science;Physiology;Process;programs;Property;Protein Biosynthesis;protein expression;Proteins;receptor mediated endocytosis;recruit;Regulation;Reporter;Research;Resolution;Role;Science;self assembly;Series;Site;Small Interfering RNA;Spectrum Analysis;Structure;System;targeted treatment;Technical Expertise;Testing;Therapeutic;Therapeutic Agents;therapeutic nanoparticles;therapeutic RNA;tool;Training;Training Programs;Transfection;Transformed Cell Line;Translations;tumor;Untranslated RNA;uptake;Vesicle;Work;Writing

PROJECT_TITLE: Cytosolic Access and Instability of DNA nanoparticles

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative

PI_NAMEs: BRINTON, ROBERTA EILEEN (contact)

PROJECT_TERMS: Address;Adherence;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Cognitive;Consent Forms;Data;data acquisition;Data Collection;data quality;Data Science Core;data sharing;Development;Documentation;Ensure;Ethics;ethnic diversity;experience;experimental study;Financial Disclosures;Goals;Good Clinical Practice;good laboratory practice;Good Manufacturing Process;Guidelines;Health;Health Insurance Portability and Accountability Act;healthspan;Human;Human Resources;human study;human subject;improved;Independent Living;Institutional Review Boards;International;life span;material transfer agreement;Mission;Monitor;operation;Participant;prevent;Procedures;Process;Productivity;programs;Protocol Compliance;Protocols documentation;Quality Control;real time monitoring;Regulation;Reproducibility;Research;Risk;Safety;sample collection;Services;sex;Site;socioeconomics;Specimen;symposium;System;Training;Training Programs;Translational Research;Update;virtual;Work

PROJECT_TITLE: Regulatory and Human Study Operations (RHSO) Core C


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The proposed research will identify the genomic variants, chromatin structures, and genes that control chondrocyte response to cartilage matrix degradation, a critical process in the development of knee osteo- arthritis. Our work will break down existing barriers by using 3D chromatin structures and a cellular model of the chondrocyte OA phenotype to interpret the mechanisms driving knee osteoarthritis.

PI_NAMEs: LOESER, RICHARD F;PHANSTIEL, DOUGLAS H. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: 3-Dimensional;Acetylation;Address;Affect;Alleles;Automobile Driving;Base Pairing;Binding;Bioinformatics;Biology;Cartilage;cartilage degradation;Cartilage Matrix;causal variant;Cell model;cell type;Chondrocytes;Chromatin;Chromatin Structure;Computer Models;Data;Data Element;Degenerative polyarthritis;Development;disorder risk;Dissection;Engineering;Enhancers;Fibronectins;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome editing;genome wide association study;Genomics;Goals;Histones;Human;human disease;Human Genome;improved;Individual;Joints;Knee;Knee Osteoarthritis;Knock-out;Linkage Disequilibrium;Maps;Measurement;Measures;Modeling;Nature;novel;Nucleic Acid Regulatory Sequences;Pathogenesis;Phenotype;Prevalence;Process;Protocols documentation;Regulatory Element;Replacement Arthroplasty;Research;Resolution;response;Rest;Risk;risk variant;RNA;Structure;symptom management;System;Techniques;therapeutic development;Time;Tissues;transcription factor;transcription regulatory network;Transcriptional Regulation;Translating;Untranslated RNA;Variant;Work

PROJECT_TITLE: Identifying novel osteoarthritis risk genes using GWAS, chondrocyte genomics, and genome editing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHEN, ZHAO  (contact)

PROJECT_TERMS: Address;Adult;Age;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Arizona;Awareness;Baltimore;Biometry;Black race;Chairperson;Clinical Trials;Cognitive;Cognitive aging;cognitive performance;Cognitive Science;cognitive testing;cohort;Cohort Studies;Collection;college;Communities;community advisory board;community engaged approach;community engagement;Dementia;Department chair;design;Discipline of Nursing;distinguished professor;Doctor of Philosophy;Education;Electronics;Enrollment;Ensure;Epidemiology;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;experience;Faculty;Funding;Geographic Locations;Geography;Goals;Health;healthspan;healthy aging;Hispanic;Human;Individual;innovation;interest;Internet;Latino;Lead;life span;Life Style;Longitudinal cohort;Methods;Monitor;multi-ethnic;National Institute on Aging;neurogenomics;neuroimaging;Neurology;Neuropsychological Tests;next generation;Not Hispanic or Latino;novel strategies;Online Systems;Outcome;outreach;Participant;participant retention;Persons;Poaceae;Population;Population Sizes;Printing;professor;Public Health;Public Health Practice;Race;racial minority;racial population;recruit;Research;Research Personnel;Rosales;sex;Site;social;social culture;Social Marketing;social media;socioeconomics;Strategic Planning;Students;Surveys;Testing;Translational Research;Underrepresented Populations;United States;Universities;virtual;Work

PROJECT_TITLE: Community Engagement, Recruitment and Retention (CERR) Core D


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: This project aims to develop a new nanoplasmonic system capable of robust, multiplexed analysis of extracellular vesicles, emerging circulating biomarkers that can be harnessed by a non-invasive liquid biopsy. Successful completion of the project will produce a robust tool that will facilitate both basic research of extracellular vesicles and their clinical research use.

PI_NAMEs: IM, HYUNGSOON  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Basic Science;Binding;Biological;Biological Assay;Biological Markers;Biological Models;Biosensing Techniques;Blood;Body Fluids;cancer biomarkers;Cancer cell line;cancer diagnosis;Cardiovascular Diseases;Cardiovascular system;cell type;Cells;Cerebrospinal Fluid;circulating biomarkers;Clinical;clinical application;Clinical Research;clinically relevant;Color;Communicable Diseases;Cytolysis;design;Detection;detection assay;detection platform;detection sensitivity;Development;Disease;Emerging Technologies;exosome;experimental study;extracellular vesicles;Fluorescence;Generations;Genetic Materials;Goals;Heterogeneity;Human;improved;Individual;innovation;insight;Integral Membrane Protein;Label;Lipids;liquid biopsy;Liquid substance;Malignant neoplasm of ovary;Malignant Neoplasms;Membrane;Methods;minimally invasive;Modeling;Molecular;molecular diagnostics;molecular marker;Molecular Probes;Monitor;Names;nano;nanoGold;nanoplasmonic;nanopore;nanoscale;Nerve Degeneration;Neurodegenerative Disorders;new technology;next generation;noninvasive diagnosis;Performance;Periodicals;Phospholipids;Plasma;pre-clinical;Procedures;Process;Production;protein biomarkers;Proteins;prototype;Reproducibility;RNA;RNA marker;Saliva;Sampling;sensor;sensor technology;Signal Transduction;Structure;Surface Plasmon Resonance;System;Technology;Technology Assessment;Testing;tool;transmission process;treatment response;tumor;Tumor-Derived;Urine;Variant;Vesicle

PROJECT_TITLE: Development of plasmon-enhanced biosensing for multiplexed profiling of extracellular vesicles

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Approximately 54% of adolescents report experiencing one or more adverse childhood experiences, making them over 1.5 times more likely to use substances; however, many adolescents with adverse childhood experiences deny substance use engagement. Using an innovative integrative model of ecological and laboratory approaches, the current study examines the role of affect in the link between childhood adversity and adolescent substance use. This research will advance NIDA’s strategic plan (Objective 1) by improving our understanding of factors that influence substance use behaviors and informing future interventions that aim to improve outcomes and reduce the health and economic costs of adolescent substance use.

PI_NAMEs: BROWN, SHAQUANNA A. (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Adolescence;Adolescent;adolescent substance use;advanced analytics;adverse childhood events;Affect;Affective;Age;Alcohols;Attention;Behavior;Behavioral;biobehavior;Cannabis;career development;Child;Child Traumatic Stress;childhood adversity;Clinical;Collection;Data;Data Analytics;Data Reporting;design;Development;Dimensions;Distress;distress tolerance;early life stress;Ecological momentary assessment;economic cost;Educational workshop;Eligibility Determination;emerging adult;Emotional;Emotions;Environment;Equilibrium;Exhibits;experience;Exposure to;Face;follow-up;Fostering;Funding;Future;Galvanic Skin Response;Genetic Complementation Test;Goals;Health Care Costs;Heart Rate;Hospitals;improved;improved outcome;indexing;Individual;innovation;Institution;Intervention;K-Series Research Career Programs;Laboratories;Link;longitudinal design;Longitudinal Studies;Measurement;Mediating;medical schools;Mentors;Mentorship;Methodology;Methods;Modeling;modifiable risk;Morbidity - disease rate;mortality;Mydriasis;National Institute of Drug Abuse;negative affect;Neurobiology;Nicotine;Participant;Pathway interactions;Patient Self-Report;Pattern;Persons;Physiological;Play;Process;programs;psychologic;Psychologist;Psychophysiology;Public Health;Questionnaires;Recording of previous events;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Research Support;resilience;response;Risk;Risk Factors;Role;screening;Severities;social;Standardization;Stimulus;Strategic Planning;Substance abuse problem;substance use;Substance Use Disorder;symposium;Task Performances;Techniques;Testing;Time;Training;Training Support;twelfth grade;United States;Universities;Visit;visual tracking

PROJECT_TITLE: Childhood adversity and substance use:  Integrating laboratory and ecological approaches to understand the role of affect

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

PI_NAMEs: CHEN, NAN-KUEI  (contact)

PROJECT_TERMS: Address;Adult;age group;Age-associated memory impairment;Aging;Algorithms;annotation  system;automated segmentation;Baltimore;Blood flow;Blood Flow Velocity;Brain;brain magnetic resonance imaging;Brain Mapping;brain morphology;carotid intima-media thickness;Clinical;clinical research site;Cloud Service;Cognitive;Cognitive aging;cognitive function;cognitive testing;Collaborations;Computer software;Computers;Data;Data Analyses;Data Collection;data harmonization;data management;data pipeline;Data Science Core;Decentralization;Dementia;design;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Echo-Planar Imaging;Engineering;Ensure;executive function;Goals;healthspan;Hemorrhage;Hippocampus;Image;image processing;Individual Differences;Intervention;large scale data;Learning Module;life span;Literature;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Manuals;Measures;meetings;Memory;Metadata;Methods;Mining;Morphologic artifacts;Morphology;multimodality;neural;neuroimaging;Neurologic;Neurologist;Neuropsychological Tests;older adult;Participant;Performance;Perfusion;Persons;Physiologic pulse;Procedures;Process;processing speed;Property;Protocols documentation;Psychometrics;Public Domains;Quality Control;repository;Reproducibility;Research;Research Personnel;Series;Site;Spanish;Spanish/English;Standardization;Structure;Support System;System;Testing;Time;tool;Training;Translating;Ultrasonography;ultrasound;Validation;White Matter Hyperintensity

PROJECT_TITLE: Cognitive Assessment and Neuroimaging (CAN) Core E


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: CLEVELAND CLINIC FOUNDATION

PHR: NARRATIVE Overall Our Center for Neurodegeneration and Translational Neuroscience (CNTN) is transforming the translational neuroscience research environment in Southern Nevada. In Phase 1, the CNTN has developed robust research infrastructure that was leveraged by local investigators to carry out innovative biomedical research projects focused on neurodegenerative disorders (NDD). In Phase 2, we ambition to develop the resources and processes necessary to reach sustainability by utilizing the evaluation reports produced by our talented Assessment Unit to elaborate our strategy, monitor progress, and make eventual adjustments to our strategy.

PI_NAMEs: KINNEY, JEFFERSON ;KIRKLAND CALDWELL, JESSICA  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Affect;age related neurodegeneration;Applications Grants;Award;biomarker discovery;Biomedical Research;brain health;Brain imaging;Caliber;career;career development;Centers of Research Excellence;Clinic;Clinical Research;cohort;Coin;Collaborations;community advisory board;Community Outreach;Data;data management;Dedications;Development;Diagnostic Procedure;Enrollment;Environment;Equipment;Evaluation Reports;Faculty;Financial Support;Fostering;Funding;Future;Goals;Grant;Healthcare;Individual;Industry;industry partner;Infrastructure;infrastructure development;innovation;Institution;Knowledge;Leadership;Lifting;Manuscripts;Mentors;Methods;Monitor;multidisciplinary;National Institute of General Medical Sciences;Nerve Degeneration;Neurodegenerative Disorders;Neurosciences;Neurosciences Research;Nevada;novel;Performance;Phase;Phenotype;Pilot Projects;Population;Population Heterogeneity;Preparation;Privatization;Process;Productivity;programs;Proteomics;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;responsible research conduct;retiree;Science;Scientist;skills;southern nevada;statistics;synergism;Talents;Testing;Therapeutic Intervention;Training;translational neuroscience;United States National Institutes of Health;Universities;volunteer;Writing

PROJECT_TITLE: Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurodegenerative;Neurosciences

PI_NAMEs: KIRKLAND CALDWELL, JESSICA  (contact)

PROJECT_TERMS: Academic support;Achievement;Administrative Personnel;Administrator;Advisory Committees;Animals;Annual Reports;Applications Grants;Basic Science;Biological Markers;brain health;Brain imaging;career;career development;Career Mobility;Centers of Research Excellence;Charge;Clinic;Clinical;Clinical Research;cohort;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Cultural Diversity;Data;data management;Data Set;Decision Making;design;Diagnostic Procedure;Ecosystem;Educational Curriculum;Environment;Evaluation;Evolution;experience;Fortification;Fostering;fundamental research;Funding;Future;Genetic;Goals;Grant;Growth;Human Resources;improved;Individual;Industry;Infrastructure;innovation;Institution;Investments;Leadership;Longitudinal cohort;Mentors;Methods;Mission;Monitor;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;Neurosciences;Neurosciences Research;Nevada;operation;Outcome;pandemic disease;Pathway Analysis;Patients;Performance;Phase;Phenotype;Pilot Projects;Population Heterogeneity;Positioning Attribute;Process;Process Assessment;Program Development;programs;rapid growth;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Science;Scientific Advances and Accomplishments;Secure;Service delivery model;southern nevada;Statistical Data Interpretation;statistics;Strategic Planning;success;Supervision;Surveys;Testing;Therapeutic Intervention;Training;translational neuroscience;Translational Research;Universities;Vision;Work

PROJECT_TITLE: CORE A: Administrative Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Physical Activity

PI_NAMEs: STERNBERG, ESTHER M. (contact)

PROJECT_TERMS: Age-associated memory impairment;Aging;arm;Autonomic nervous system;Behavioral;biobehavior;Biochemical;biosignature;Cardiac;Cognition;Cognitive;cognitive change;cohort;Collection;computerized data processing;Computers;cost;Data;Data Collection;Data Science Core;data streams;Dimensions;Emotions;empowerment;exhaustion;frailty;Frequencies;Genetic Transcription;Glass;Goals;Hand;healthspan;Heart Rate;heart rate variability;Hormones;Human;Immune;Impaired cognition;innovation;Investigation;lexical;life span;Linguistics;Mass Spectrum Analysis;Measures;Modeling;Molecular;Monitor;Motion;Motor;neural;novel;Online Systems;Participant;Pathologic;Pattern;Performance;personalized predictions;Persons;Phenotype;Physical activity;Physiological;Positioning Attribute;Process;response;Rest;sedentary lifestyle;Short-Term Memory;Sleep;sleep quality;social;Speech;speech processing;Stress;systematic review;Technology;Time;video module;Voice;wearable device;web site;Work

PROJECT_TITLE: Non-Invasive Technology (NIT) Core F


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Disability Research;Kidney Disease;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: The over 44 million persons worldwide living with dementia are primarily older adults with Alzheimer’s Disease (AD) or related dementias (ADRD). The consequences of physical disability and death from AD combined with unclear clinical benefit of AD treatment motivate the search for targets of preventive intervention. We hypothesize that declining kidney health, which is a model of premature aging that relates to cognitive and physical decline long before onset of dementia and physical disability, is the source of modifiable biological mechanisms; thus, we propose to leverage data from over 22,000 older adults to identify kidney-related biomarkers that can inform prevention and prediction of age-related ADRD and physical disability.

PI_NAMEs: SHARDELL, MICHELLE DENISE (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 25-hydroxyvitamin D;Address;Adult;Affect;age related;aged;Aging;aging biomarker;aging mechanism;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Biological;Biological Aging;Biological Markers;Biology;biomarker identification;Blood Tests;Body System;bone;Brain;candidate marker;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Treatment;Code;cofactor;Cognition;Cognitive;cognitive performance;cohort;Cohort Studies;Communities;Computer software;Data;data harmonization;Dementia;Development;disability;Disease;Early identification;epidemiology study;Event;Excretory function;fibroblast growth factor 23;Future;GDF15 gene;Geroscience;Goals;hallmarks of aging;Health;Homeostasis;Hormones;Human;human old age (65+);Impaired cognition;Impairment;improved;Individuals with physical disabilities;innovation;Intervention;Joints;Kidney;Kidney Diseases;Life Expectancy;Link;Longitudinal Studies;Measures;metabolomics;Methods;Minerals;Modeling;Molecular;multidimensional data;Muscle;Musculoskeletal;Nerve Degeneration;Nervous System;Neurologic;Neuronal Injury;novel;novel marker;older adult;Outcome;Pathology;Persons;Physical Performance;physically handicapped;post gamma-globulins;predictive modeling;Premature aging syndrome;prevent;Prevention;preventive intervention;Property;Proteins;Proteomics;Public Health;Renal function;Renal tubule structure;Research;Risk;Risk Factors;Skeletal Muscle;Source;Statistical Methods;Structural Models;Testing;therapeutic target;Time;tool;Uremia;Vitamin D

PROJECT_TITLE: Statistical Methods for Kidney Markers as Shared Determinants of Dementia and Physical Disability in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE Exhaustion of CD8+T cells is a major barrier to successful immunotherapy for cancer. In this proposal, we aim to investigate the molecular mechanism by which Znf740, a novel transcription factor, regulates effector function vs. exhaustion of CD8+T cells. Our studies could lead to new clinical trials to overcome the current limitations of immunotherapy for cancer.

PI_NAMEs: POOJARY, VENUPRASAD K (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Antitumor Response;Binding;cancer immunotherapy;Cancer Model;cancer therapy;CAR T cell therapy;Carcinoembryonic Antigen;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cell Physiology;Cells;chimeric antigen receptor T cells;Clinical Trials;colon cancer patients;Colon Carcinoma;Complex;Data;Down-Regulation;effector T cell;Equilibrium;exhaust;exhaustion;Exhibits;Family;Gene Expression Profile;Growth;improved outcome;Interferons;Knock-in Mouse;MC38;Mediating;member;Molecular;neoplastic cell;novel;overexpression;Pathway interactions;patient derived xenograft model;Patients;prevent;Production;programmed cell death protein 1;promoter;receptor;reconstitution;Regulation;Resistance;response;Solid Neoplasm;Sumoylation Pathway;T-bet protein;T-Lymphocyte;Testing;Therapeutic;therapeutic target;TNF gene;transcription factor;transgene expression;Transgenic Mice;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Infiltrating Lymphocytes;Zinc Fingers

PROJECT_TITLE: Znf740 in the regulation of CD8+T cell exhaustion

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences

ORG_CITY: PISCATAWAY

ORG_DEPT: PSYCHOLOGY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  Approaching a comprehensive account of behavioral, neural and genetic mechanisms for the precision and lastingness of learning-induced auditory system reorganization will lead the future of hearing-related medical practices to achieve effects of auditory training that are acoustically rich as well as long-lasting. Use of a small- molecule epigenetic approach is a tool for gene discovery that will also aid precision medicine to its full potential for therapeutics that can coordinate complex effects that likely involve families of interacting genes. HDAC- inhibitors may further succeed in producing robust auditory remediation on an individual-person basis, especially when sound exposure therapies alone fail to induce relief, as in cases of long-standing hearing problems, in the aged brain where cholinergic signaling is known to be disrupted, or in rehabilitation following extreme auditory disturbances including cochlear implants.

PI_NAMEs: BIESZCZAD, KASIA  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acceleration;Acoustics;adenovirus mediated delivery;Adult;aging brain;Anesthesia procedures;Animals;Association Learning;Auditory;Auditory area;auditory discrimination;Auditory system;Behavior;Behavioral;Behavioral Assay;Behavioral Model;Brain;Candidate Disease Gene;Categories;cholinergic;Cholinergic Receptors;Chromatin;Chronic;Cochlear Implants;Communication;Complex;Coupled;Cues;Data;Deacetylase;designer receptors exclusively activated by designer drugs;Desire for food;Discrimination;Discrimination Learning;Electrophysiology (science);Ensure;Enzymes;Epigenetic Process;Event;experience;Family;Food;Future;gene discovery;Gene Expression;gene interaction;Gene Targeting;Genes;Genetic;genetic approach;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Hearing;Hearing problem;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;Hour;Human;Individual;inhibitor;learned behavior;Learning;Life;Link;Maintenance;Mediating;Medical;member;Memory;Molecular;Molecular Conformation;mutant;neural;neuromechanism;Neuronal Plasticity;Neurosciences;Outcome;Persons;pharmacologic;Physiological;Physiology;precision medicine;Process;Quantitative Reverse Transcriptase PCR;Rattus;Recording of previous events;Regulation;Rehabilitation therapy;remediation;Research;response;Rewards;Rodent;Role;Sensory;sensory cortex;Signal Transduction;Site;Sleep;small molecule;sound;Specificity;stem;synergism;System;Techniques;Testing;Therapeutic;tool;Training;transcriptome sequencing;Transgenic Organisms;Viral

PROJECT_TITLE: Molecular epigenetic mechanisms that transform the auditory system for learning and memory

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: HUENTELMAN, MATT  (contact)

PROJECT_TERMS: Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Area;B cell repertoire;B-Cell Antigen Receptor;Bar Codes;biobank;Biological Assay;Biological Markers;biomarker development;biomarker discovery;Blood;blood fractionation;Brain;Cells;Cognitive;Cognitive aging;cognitive performance;cohort;Communities;Consultations;Country;Data;Data Analyses;data repository;Data Science Core;Data Set;data submission;data warehouse;database of Genotypes and Phenotypes;Deposition;Development;Diabetes Mellitus;DNA;Dryness;Ensure;epigenetic clock;exosome;experience;genetic risk factor;genome sequencing;genome-wide;genomic data;Genotype;Goals;healthspan;human subject;Hypertension;Immune;Immunologic Markers;Immunologist;Individual;Inflammatory;interest;Letters;life span;Measurement;Measures;Mediating;member;memory consolidation;Molecular;Molecular Analysis;Molecular Profiling;Neurodegenerative Disorders;next generation sequencing;novel;Participant;Pathway interactions;Peptides;Plasma;Play;polygenic risk score;Process;protein biomarkers;public database;repository;Research;Research Personnel;Resources;Risk Factors;RNA;Role;Sampling;Scientist;Serum;Signal Pathway;Sleep;Specimen;Spottings;success;T-Lymphocyte;tau Proteins;Testing;transcriptome sequencing;Universities;Viral;Whole Blood;whole genome;Work

PROJECT_TITLE: Molecular Profiling (MP) Core G


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: NARRATIVE  Clinical and Translational Research Core (CTRC)  The complex cascade of biochemical and neurophysiological changes occurring in Alzheimer’s disease (AD)  and Parkinson’s disease (PD)—the two most common neurodegenerative diseases of the elderly—requires new  research approaches that integrate information from multiple distinct but parallel sources including molecular  profiling, multi-modal brain imaging, and clinical assessments. The Cleveland Clinic Lou Ruvo Center for Brain  Health (LRCBH) and the University of Nevada-Las Vegas (UNLV) have been collaborating on the study of a  group of individuals with early stage AD and PD for the past 5 years, collecting a variety of clinical, biological,  and imaging data on these individuals each year. This research has been studied in a variety of innovative  projects and funding for the study has been used to develop the research infrastructure of southern Nevada. For  Phase 2 we plan to extend the study up to 10 years and look more specifically at the role of inflammation in  these two diseases.

PI_NAMEs: BERNICK, CHARLES  (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Age;Aliquot;Alzheimer's Disease;biobank;Biochemical;Biological;Biological Assay;Biological Markers;Biomedical Research;blood-based biomarker;brain health;Brain imaging;Centers of Research Excellence;Clinic;Clinical;Clinical assessments;clinical diagnosis;Clinical Research;Cognitive;cognitive testing;cohort;Collaborations;Collection;Communities;community advisory board;Community Outreach;comparison group;Complex;COVID-19;Data;Databases;Dedications;Diagnostic;Disease;Education;Education and Outreach;Elderly;Elements;Enrollment;Ensure;equity, diversity, and inclusion;Ethnic Origin;Evaluation;experience;follow-up;Funding;Genetic;Goals;high risk population;human old age (65+);Image;Impaired cognition;Individual;Inflammation;Infrastructure;innovation;Instruction;longitudinal analysis;meetings;mild cognitive impairment;minority communities;minority engagement;Molecular Profiling;multimodality;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuroinflammation;neurophysiology;Neuropsychology;Nevada;outreach;outreach program;pandemic disease;Parkinson Disease;Participant;participant safety;patient population;performance tests;Phase;Phenotype;Population;Procedures;Productivity;programs;Psychometrics;Race;recruit;Recurrence;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Review Committee;Role;Sampling;Science;Services;socioeconomic diversity;Source;southern nevada;Specimen;Standardization;success;translational neuroscience;Translational Research;Universities;Vision;web site

PROJECT_TITLE: CTRC Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Precision Medicine;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Address;Adult;Age;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;bilingualism;biomarker discovery;Black race;Blood;Clinical;clinical research site;Cognitive;Cognitive aging;cognitive function;cognitive task;cognitive testing;cohort;Cohort Studies;Collaborations;Collection;Communities;Consent;Country;dashboard;Data;Demographic Factors;demographics;design;Development;Dryness;Electronics;empowerment;Enrollment;executive function;Frequencies;Funding;Future;Generations;Genotype;Goals;Grant;Health;healthspan;Hispanic;Hour;Human;Individual;interest;Internet;Latino;life span;Life Style;longitudinal dataset;Medical;Memory;model development;Molecular;Molecular Genetics;neuroimaging;normal aging;Not Hispanic or Latino;novel marker;Online Systems;operation;Paired-Associate Learning;Participant;Patient Self-Report;Performance;performance tests;personalized approach;Persons;Phase;Play;Population;Population Heterogeneity;precision medicine;Predictive Factor;predictive modeling;Predisposition;Printing;processing speed;Quality of life;Reaction Time;Recontacts;recruit;Research;Research Personnel;Resistance;Risk;Role;Sampling;Site;SNP array;social;Spanish/English;Spottings;Statistical Data Interpretation;Surveys;Testing;Time;Visual;Work

PROJECT_TITLE: Project 1: MindCrowd: Precision Aging Cognitive Assessment Through a Web-based Network


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Microbiome;Pediatric;Pediatric - AIDS;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Enteric microbiomes contribute to immune development yet very little is known about the viral component. We will test the hypotheses that the infant enteric virome is vertically transferred, and the expanded enteric virome of infants born to mothers who are HIV-infected leads to accelerated immune ontogeny and activation. Understanding the factors that shape the infant gut virome and its consequent impact on immune ontogeny could facilitate the development of interventions to reduce infant morbidity and mortality, particularly for those that are exposed to HIV.

PI_NAMEs: JASPAN, HEATHER BERYL (contact);VARSANI, ARVIND

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Adjuvant;Adult;Anti-viral Therapy;Antibiotic Prophylaxis;Bacteria;bacterial community;bacteriome;Bacteriophages;Biological Assay;Birth;Cell Maturation;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Data;Development;Disease;Enteral;Exposure to;Feces;feeding;Germ-Free;Growth;Growth and Development function;gut inflammation;gut microbiome;Health;HIV;HIV Infections;Human;Human Microbiome;Immune;immune activation;Immunity;immunological diversity;Immunologics;immunoregulation;infancy;Infant;Infant Health;infant morbidity;infant morbidity/mortality;Inherited;intestinal barrier;Intestines;Life;Linear Regressions;Link;Maternal Health;maternal microbiota;Measures;metagenome;metagenomic sequencing;microbial;microbiome;microbiota;MicroRNAs;Modeling;Mothers;Mus;Natural Killer Cells;Neonatal;novel virus;Nucleic acid sequencing;Nucleic Acids;Outcome;Parents;particle;Phenotype;Plasma;Play;Population;Postpartum Period;Probiotics;Role;Sampling;Shapes;success;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;therapy development;Time;transmission process;Vagina;vector vaccine;Vertical Transmission;Viral;virome;Virus;virus identification;Work

PROJECT_TITLE: Influence of maternal virome and HIV status on infant gut virome, growth and immunity


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PHR: NARRATIVE Data Management and Statistics Core (DMSC) Derivation of novel insights and new knowledge is predicated on sound data management practices that allow for reliable validation and replication of results, thereby permitting new and innovative research to be built on existing information and providing a basis for training early investigators in practical data analysis and management. Consistent with the primary aims of the Center for Neurodegeneration and Translational Neuroscience (CNTN), the Data Management and Statistical Core seeks to advance the scientific process and the goals of the CNTN by providing content expertise in data science, informatics, and statistics, as well as, low- friction information technology solutions for managing, analyzing, extracting knowledge, and sharing research data. These functions are essential in order for the full value of public investment in research to be realized.

PI_NAMEs: MILLER, JUSTIN BENJAMIN (contact)

PROJECT_TERMS: Adopted;advanced analytics;Alzheimer's Disease;Alzheimer's disease therapeutic;Animal Model;Architecture;Archives;Award;Biological Markers;biomedical informatics;Biometry;Brain;brain health;Brain imaging;California;Career Mobility;Centers of Research Excellence;Characteristics;Clinic;Clinical Research;cloud based;Cognitive;cohort;Collaborations;Communities;Complex;Computer software;Consultations;Data;Data Analyses;Data Element;data framework;data infrastructure;data integration;data management;Data Science;Data Set;data streams;Databases;Dedications;Derivation procedure;Development;digital;Disease;Doctor of Philosophy;electronic data;Ensure;Faculty;flexibility;Formulation;Fostering;Friction;Funding;Future;Genetic;Goals;Growth;high standard;Human;Image;Individual;industry partner;Inflammation;Informatics;informatics infrastructure;Information Technology;Infrastructure;innovation;insight;interest;Investments;Knowledge;Leadership;Liquid substance;member;Mentorship;Modernization;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;Neurology;Neuropsychology;Neurosciences;Nevada;novel;novel strategies;older adult;open source;Parkinson Disease;Participant;Patients;Phase;Positioning Attribute;Practice Management;Process;protocol development;Publications;quantitative imaging;Research;research and development;Research Infrastructure;Research Institute;Research Personnel;Resources;Sample Size;Scientific Advances and Accomplishments;Secure;Security;Services;sound;Source;statistics;Structure;System;Technology;Testing;tool;Training;Translating;translational neuroscience;Translational Research;Universities;Validation;Work;Writing

PROJECT_TITLE: CORE C: DMSC Core


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Genetics;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This study builds on an existing cohort of high-risk births to examine how characteristics of maternal lifetime trauma history, and maternal caregiving sensitivity are associated with their 4-year old children’s behavioral health problems and salivary DNA methylation.

PI_NAMEs: BASU, ARCHANA  (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: 4 year old;Accounting;Address;Adolescent;Adult;Adverse event;Affect;Automobile Driving;Behavior;behavioral health;behavioral outcome;biobehavior;biological systems;Birth;caregiving;Characteristics;Child;Child Abuse and Neglect;Child Behavior;Child Health;Childbirth;Childhood;Chronic;cohort;Data;design;Development;DNA Methylation;early childhood;Epigenetic Process;experience;externalizing behavior;First Pregnancy Trimester;follow-up;Funding;Gene Expression Regulation;generalized anxiety;Generations;Genes;Gestational Age;Goals;Grant;Health;High Prevalence;high risk;Infant;intergenerational;Intervention;intimate partner violence;Life Cycle Stages;Link;Literature;Live Birth;Longitudinal cohort;maltreated children;maternal caregiving;Mediating;Mental Depression;Methodology;Modeling;modifiable risk;Mothers;National Institute of Child Health and Human Development;offspring;Outcome;Peruvian;Policies;Post-Traumatic Stress Disorders;postnatal;Pregnancy;Pregnant Women;prepregnancy;preventive intervention;Problem behavior;prospective;protective effect;protective factors;Psychopathology;Public Health;Recording of previous events;recruit;Regulation;Reporting;Research;Research Design;Risk;Role;Salivary;Sample Size;Sampling;Shapes;Skin;Stress;System;Testing;theories;Time;transmission process;Trauma;Violence;Woman;Work

PROJECT_TITLE: Intergenerational impact of maternal trauma history on preschoolers' behavioral health outcomes: Assessing links with caregiving sensitivity and DNA methylation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: BERKELEY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed program will train new cohorts of demographers to study contemporary issues in population health and wellbeing. Demography is the study of population size, structure, and change. Most contemporary social problems have demographic components, as for example differential fertility rates, rising mortality rates, or changes in migration. By understanding dynamics of mortality, fertility, migration, marriage and divorce, we are better able to develop social policy that promotes child health and family wellbeing.

PI_NAMEs: FEEHAN, DENNIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Demography;Training

PROJECT_TITLE: Interdisciplinary Training in Demography


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: RYAN, LEE  (contact)

PROJECT_TERMS: Age;age related;Age-associated memory impairment;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Arizona;Baltimore;Biological Markers;Biometry;Black race;Blood;Brain;brain health;brain magnetic resonance imaging;cardiovascular insufficiency;Categories;Characteristics;Chronic Disease;Classification;clinical research site;Cognition;Cognitive;cognitive change;cognitive function;Collaborations;Data;Dementia;Demographic Factors;Diabetes Mellitus;Diagnostic;Diet;Diffusion Magnetic Resonance Imaging;Education;Ethnic Origin;Ethnic Population;executive function;Genetic Risk;genetic variant;Genomics;Glucose;Goals;Health;healthspan;healthy lifestyle;Heart Diseases;Hippocampus;Hispanic;Hispanic Populations;Human;Hypertension;Immune System Diseases;Impaired cognition;improved;Independent Living;indexing;Individual;Individual Differences;Inflammation;Inflammatory;Intervention;Latino;Life;life span;Life Style;lifestyle factors;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Memory;Mental Depression;Metabolic Diseases;Methods;neuroimaging;Not Hispanic or Latino;novel;novel diagnostics;Occupational;older adult;Participant;Pattern;Perfusion;personalized approach;Physical activity;Population;Population Heterogeneity;precision medicine;predictive modeling;processing speed;Productivity;prognostic;psychosocial;Quality of life;Race;racial population;Recording of previous events;recruit;resilience;resilience factor;Rest;Risk;Risk Factors;risk mitigation;sex;Social Behavior;Social Interaction;Social isolation;Stress;stressor;Stroke;Structure;System;Therapeutic;ultrasound;Universities;Vascular Diseases

PROJECT_TITLE: Project 2: Aging Healthy Together: Precision Profiles of Resilience and Risk


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;Immunization;Infectious Diseases;Malaria;Neurosciences;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The proposed research is relevant to public health because the pathogenesis of malaria is T cell-driven and we have an incomplete understanding of the T cell response in malaria, a disease that kills approximately 0.5 million people every year. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to developing fundamental knowledge that will help to reduce the burdens of human disease and disability.

PI_NAMEs: EVAVOLD, BRIAN D;LAMB, TRACEY JANE (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute Lung Injury;adaptive immunity;Adhesions;Affect;Affinity;Anti-malarials;Antibody Formation;antigen-specific T cells;Antigens;Biological Assay;Blood;Blood - brain barrier anatomy;Brain;brain endothelial cell;CD8-Positive T-Lymphocytes;Cells;Cellular biology;Central Nervous System;Central Nervous System Viral Diseases;Cerebral Malaria;Cessation of life;Coupled;Cross Presentation;cytokine;Data;design;Development;disability;Disease;Disease Outcome;Event;Experimental Models;Frequencies;Future;Goals;human disease;Immune;Immune response;Immunodominant Epitopes;immunopathology;Impaired cognition;improved;Individual;Infection;Infection Control;insight;Interferon Type II;Interleukin-10;Intervention;Knowledge;Laboratories;Life Cycle Stages;Link;Liver;Liver Fibrosis;Malaria;Malaria Vaccines;Measures;Mediating;Mission;Modeling;Molecular;Nervous System Trauma;novel;novel marker;Organ;Outcome;Parasitemia;Parasites;Pathogenesis;Pathogenicity;Pathology;Peptides;Persons;Phagocytosis;Plasmodium;Plasmodium berghei;Population;Public Health;Reaction;Research;response;Shapes;skills;Stains;Survivors;synergism;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Therapeutic Intervention;trafficking;two-dimensional;United States National Institutes of Health;Vaccine Design;Vaccines;Work

PROJECT_TITLE: Pathogenic low affinity CD8 T cells in malaria


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Skin Cancer

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE A portion of patients with metastatic melanoma, and aggressive form of skin cancer, have durable responses to immunotherapies, but most do not. In this proposal we elucidate the role of an understudied axis with important roles in anti-tumor immunity and resistance to immunotherapies. We will use novel models, methodologies and a large cohort of patient biopsies to elucidate the molecular underpinnings of a specific mechanism of resistance to immunotherapies, test different therapeutic strategies to overcome this mechanism, and provide comprehensive high-resolution landscape of immunotherapy resistance in melanoma.

PI_NAMEs: IZAR, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Adoptive Cell Transfers;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antibodies;Autologous;Binding Proteins;Biochemical;Biological Assay;Biopsy;cancer cell;cancer immunotherapy;cancer infiltrating T cells;CD28 gene;CD58 Antigens;CD58 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;cell killing;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clonal Expansion;Co-Immunoprecipitations;Coculture Techniques;cohort;Collection;CRISPR screen;cytokine;Cytolysis;Data Analyses;data tools;Defect;Down-Regulation;drug development;Ecosystem;Engineering;Exclusion;Flow Cytometry;Genes;Genetic;genome-wide;Genotype;Goals;Homologous Gene;humanized mouse;Immune;Immune checkpoint inhibitor;Immune Evasion;immune resistance;Immunofluorescence Immunologic;immunological synapse;Immunotherapy;Impairment;Implant;In Vitro;in vivo;in vivo Model;Infiltration;innovation;Lymphocyte Activation;Lymphocytic Infiltrate;Machine Learning;Macrophage;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Mediating;Melanoma;Melanoma Cell;Melanoma patient;Metastatic Melanoma;Methodology;Methods;Modeling;Molecular;Monoclonal Antibodies;mouse model;multimodality;Mus;neoplasm resource;neoplastic cell;novel;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;preservation;Production;programmed cell death ligand 1;Proliferating;protein expression;Proteins;reconstitution;Recycling;Resistance;resistance mechanism;Resolution;responders and non-responders;response;RNA;Role;Sampling;Scientist;Signal Transduction;single cell genomics;single-cell RNA sequencing;Skin Cancer;stem cell function;Survivors;T cell infiltration;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapeutic development;Tissues;tool;tumor;Tumor Escape;Tumor Immunity;Up-Regulation;virtual;Western Blotting;Work;Yin

PROJECT_TITLE: The role of the CD58:CD2 axis in cancer immune evasion and resistance to immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PHR: NARRATIVE Brain Imaging Core The Center for Neurodegeneration and Translational Neuroscience (CNTN) COBRE Phase 2 Brain Imaging Core (BIC) will provide advanced neuroimaging technologies and data analysis methods to current and future COBRE projects and other interested researchers. The BIC will be committed to the training of junior investigators in advanced imaging methods and analyses, as well as advancing the sustainability of the Core and the CNTN. The proposed BIC is highly relevant to public health because it promotes training, access and usage of advanced neuroimaging technologies, and data analysis methods leading to better characterization of human brain function and thus will promote advancing understanding of neurodegenerative diseases.

PI_NAMEs: CORDES, DIETMAR  (contact)

PROJECT_TERMS: Alzheimer's Disease;Amyloid;Amyloid deposition;analytical method;artificial neural network;Award;Brain;Brain imaging;career;Centers of Research Excellence;cerebral atrophy;Classification;Clinical;Clinical Research;Clinical Trials;Cognitive;cohort;Collaborations;Communities;Computer software;convolutional neural network;Data;Data Analyses;Data Analytics;data fusion;data management;data sharing;deep neural network;denoising;Deposition;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Disease Progression;Early Diagnosis;Echo-Planar Imaging;Encephalitis;Fiber;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Human;Image;Image Analysis;imaging biomarker;imaging facilities;imaging modality;improved;Infrastructure;Institution;interest;Knowledge;Machine Learning;machine learning method;Magnetic Resonance Imaging;Measurement;Metabolism;Methods;mild cognitive impairment;Modality;Motion;multimodal fusion;Multivariate Analysis;Nerve Degeneration;Network-based;Neurodegenerative Disorders;neuroimaging;Neurosciences;Nevada;Noise;novel;novel imaging technique;novel therapeutics;Parkinson Disease;Patients;Pattern;Phase;Pilot Projects;Positron-Emission Tomography;Public Health;Quality Control;Research;Research Personnel;Research Support;Rest;Role;Sampling;Services;Signal Transduction;Slice;statistics;success;System;tau Proteins;Techniques;Technology;Testing;therapy development;tool;Training;training opportunity;translational neuroscience;Translational Research;Universities;user friendly software;Water;white matter

PROJECT_TITLE: CORE D: BIC Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE The intersection of smoking and HIV/AIDS poses a serious public health threat in Vietnam. Vietnam is dealing with these two challenges with parallel rather than integrated plans. Using a computer-tailored texting intervention, in a sustainable manner, we seek to promote use of an underused, available, government-funded resource (quitline) and nicotine replacement therapy (NRT) that the quitline provides, thus, promoting cessation among PLWH.

PI_NAMEs: NGUYEN, HOA ;SADASIVAM, RAJANI  (contact)

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Address;Ambulatory Care Facilities;antiretroviral therapy;Carbon Monoxide;Cessation of life;Clinic;Clinical;Collaborations;Community Health Aides;Complex;Computers;contextual factors;Counseling;COVID-19;Data;Development;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;Expert Systems;Feedback;follow-up;Funding;Government;Health;Health Resources;HIV;HIV/AIDS;Human immunodeficiency virus test;improved;Infection;Infrastructure;innovation;Institution;Intervention;Interview;learning progression;Letters;Machine Learning;Mediating;Medical;men;mHealth;Minority;Modeling;Motivation;National Heart, Lung, and Blood Institute;nicotine replacement;Outcome;Patients;peer;Persons;population health;Practical Robust Implementation and Sustainability Model;Prevalence;Process;Process Measure;programs;Protocols documentation;Provider;Province;Public Health;public health insurance;quitline;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research Personnel;Resources;Self Efficacy;Smoker;Smoking;Smoking Behavior;smoking cessation;Smoking Cessation Intervention;social stigma;socioeconomic disadvantage;Specialist;substance use;System;tailored messaging;Technology;Telephone;Testing;Text;Text Messaging;text messaging intervention;Tobacco;Tobacco use;Training;United States National Institutes of Health;Universities;Vietnam;Vietnamese;willingness;Woman;Work;Writing

PROJECT_TITLE: mHealth Messaging to Motivate Quitline use and Quitting among Persons Living With HIV in Vietnam (M2Q2-HIV)


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE COVID-19 disease has killed over half a million Americans but our present understanding of its pathogenesis remains based on observational studies that have not reached a clear consensus mechanism. To address this gap in knowledge we have engineered mice that become infected by SARS-CoV-2 virus in a manner that faithfully reflects the human disease, including lethal lung disease and hypoxemia, and in which we can prevent or confer infection of specific cell types to define their roles. We will use these new mouse models and infection of human and mouse lung slices to functionally determine the cellular mechanisms that underlie COVID-19 lung disease, an important step in designing new therapies and halting future outbreaks.

PI_NAMEs: KAHN, MARK L (contact);MORRISEY, EDWARD E

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;acute COVID-19;acute infection;Acute Respiratory Distress Syndrome;Address;AGTR2 gene;Alveolar;American;Animal Model;Autopsy;betacoronavirus;Binding;Biological Assay;Blood;Blood Vessels;Cause of Death;Cell Lineage;Cell Surface Proteins;cell type;Cells;Cessation of life;Chronic;Chronic lung disease;Consensus;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 pathogenesis;COVID-19 severity;COVID-19 test;Cultured Cells;cytokine;Defect;defined contribution;design;Development;Disease;disease model;disease phenotype;Engineering;Epithelial Cells;Epithelium;Etiology;Event;experience;Extracorporeal Membrane Oxygenation;Foundations;Functional disorder;future outbreak;Gene Expression;Genetic;genetic approach;Genetic Models;Human;human disease;human model;Hypoxemia;Hypoxia;Infection;Inflammatory;Influenza;influenza infection;insight;Investigation;K-18 conjugate;Knock-in;Knock-in Mouse;knockin animal;Knowledge;Long COVID;Lung;Lung Diseases;lung injury;Maps;Mechanical ventilation;Mediating;Modeling;Molecular;mouse genetics;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;Observational Study;Organ;Oxygen;Pathogenesis;Pathogenicity;Pathology;Patients;Phenotype;post SARS-CoV-2 infection;prevent;Primary Infection;protein expression;pulmonary vascular cells;Reporting;Respiratory distress;Respiratory Failure;Respiratory System;Respiratory Tract Infections;response;Role;Sampling;SARS-CoV-2 infection;Secondary to;Slice;Solid;Specificity;supplemental oxygen;Testing;Thrombosis;thrombotic;Tissues;Transgenes;Transgenic Organisms;vascular contributions;Vascular Diseases;Viral;Virus

PROJECT_TITLE: Genetic Investigation of Covid 19 in Lung Disease

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: WORLEY, PAUL F (contact)

PROJECT_TERMS: Adult;Age;age related biomarkers;age related changes;Age-associated memory impairment;aged;Aging;aging process;Alzheimer's Disease;Alzheimer's disease brain;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;asymptomatic Alzheimer's disease;autism spectrum disorder;Biochemical;Biological Assay;Biological Markers;Black Populations;Blood;Brain;brain health;brain pathway;candidate marker;cardiovascular insufficiency;Categories;Cell membrane;Clinical Data;Cognition;Cognition Disorders;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive performance;cohort;Collaborations;Companions;Complex;Coupled;Cross-Sectional Studies;Databases;Dementia;Disease Progression;extracellular;Extracellular Protein;FRAP1 gene;Functional Magnetic Resonance Imaging;Gene Expression;Glucose;glycerophosphodiester phosphodiesterase;Glycosylphosphatidylinositol Linkage;GPI Membrane Anchors;Growth Factor;Health;healthspan;hippocampal pyramidal neuron;Hippocampus;Hispanic;Homeostasis;Human;Immune System Diseases;Impaired cognition;Individual;Inflammation;inhibition of autophagy;insight;Integral Membrane Protein;Interneuron function;Interneurons;Latino;life span;Link;link protein;Longevity;Mass Spectrum Analysis;Measures;Mediating;Mental Depression;Metabolic;Metabolism;mild cognitive impairment;molecular marker;Molecular Profiling;Monitor;Motor Neurons;Mus;Neocortex;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuronal pentraxin;neuronal survival;Neurons;neuropathology;Neurosciences Research;non-demented;normal aging;Not Hispanic or Latino;novel;Oxidation-Reduction;Oxidative Stress;Parvalbumins;Pathway interactions;Peptide Hydrolases;Peripheral;peroxiredoxin;peroxiredoxin I;Pharmacology;Play;precision medicine;predictive marker;protein biomarkers;Protein-Serine-Threonine Kinases;Proteins;Proteomics;Publishing;Reaction;Research Personnel;resilience;response;Risk;Risk Factors;Role;Sampling;secretase;sensor;Serine;Signal Transduction;Social isolation;Stress;Structure;success;tau Proteins;Technology;Testing;Therapeutic;tool;translational study;Translations

PROJECT_TITLE: Project 3: Precision biomarkers of Brain Health, Age-related Cognitive Impairment and AD


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Palliative Care;Primary Health Care;Telehealth

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Older adults with serious illness and their caregivers have high rates of anxiety and limited access to effective, non-pharmacological treatments. A recent National Academy of Medicine report recommended increased emphasis on disseminating and implementing evidence-based psychotherapies in order to have maximal public health impact. Through this work, I will identify a sustainable and potentially scalable dyadic intervention and delivery model to manage symptoms of anxiety in older adults with serious illness and their caregivers in primary care.

PI_NAMEs: KOZLOV, ELISSA K (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Adult;Aging;Anxiety;anxiety management;anxiety reduction;anxiety symptoms;Appointment;Area;Award;Behavior Therapy;Behavioral;Benchmarking;burnout;career;career development;Caregivers;caregiving;Clinical;Clinical Trials;coping;Coping Skills;Data;Data Analyses;Dedications;Development Plans;dissemination science;Distress;Dose;Dyspnea;efficacy evaluation;Elderly;evidence base;experience;Face;Family;Family Caregiver;Fatigue;Future;geriatric mental health;Geriatrics;Goals;group intervention;Health;Health Personnel;Health Policy;Health Resources;Healthcare Systems;high risk;Hospitals;implementation science;improved;Individual;innovation;Intervention;Interview;Israel;Lead;Leadership;Licensing;Manuscripts;Medicine;Meditation;member;Mental Depression;Mental Health;Mental Health Services;Mentors;Mentorship;Methodology;mHealth;mhealth interventions;mindfulness;Mindfulness Training;Modeling;mortality;New Jersey;Nonpharmacologic Therapy;novel;older adult;Outcome;Pain;Palliative Care;Participant;Patients;Pattern;Peer Review;Persons;Polypharmacy;Population;Positioning Attribute;Post-Traumatic Stress Disorders;Primary Care;primary care clinic;Protocols documentation;Provider;Psychiatrist;psychoeducation;psychologic;Psychologist;Psychotherapy;Public Health;Public Health Schools;Quality of life;Randomized;Recommendation;recruit;reduce symptoms;Reporting;Research;Research Personnel;response;Risk;Sampling;satisfaction;Schedule;skills;Stress;stress management;Symptom Burden;symptom management;Symptoms;Targeted Research;Testing;Therapeutic Intervention;Time;Training;Transportation;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;usability;Wood material;Work

PROJECT_TITLE: Piloting an mHealth-delivered Mindfulness Therapy with Patients with Serious Illness and their Caregivers to Alleviate Symptoms of Anxiety


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Prevention

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Narrative: Typical development of both the optical and neural visual systems is dependent on the quality and alignment of images formed by the eyes. The goal of the proposed research is to understand how infants and young children are able to focus and align their eyes despite the immaturities in their vision, and how clinical conditions can disrupt this coordination. These studies are designed to understand typical and atypical development with the goal of improving clinical care and the prevention of strabismus and amblyopia.

PI_NAMEs: CANDY, T ROWAN (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;3D world;Age;Amblyopia;Anisometropia;Automobile Driving;Brain;central visual field;Characteristics;Child;Childhood;Clinical;clinical care;Clinical Pathways;Clinical Trials;Computer Simulation;Databases;design;Development;Disease;Disparity;early childhood;Environment;evidence base;evidence based guidelines;experience;Eye;Eye Movements;Eyeglasses;Goals;Human;Human Development;Hyperopia;Image;image registration;improved;infancy;Infant;insight;Left;Literature;Location;model building;Motor;motor control;Movement;neural;novel strategies;oculomotor;Optics;Patients;Performance;Peripheral;postnatal development;postnatal human;Prevention;Prevention Guidelines;Process;Property;Refractive Errors;Research;Residual state;response;Retina;retinal imaging;Risk;Role;Sensorimotor functions;simulation;statistics;Stimulus;Strabismus;Structure;success;Systems Development;Testing;Texture;tool;Vision;vision development;Visual;Visual Cortex;Visual Fields;Visual System

PROJECT_TITLE: Accommodation and Defocus in the Infant Visual System

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


PHR: Project Narrative The renewal of the IRACDA at Rutgers – INSPIRE Postdoctoral Training Program - will support the training opportunities for INSPIRE Fellows, postdoctoral fellows who will be prepared to excel as the next generation of scientist-educators. INSPIRE postdoctoral training in research and education will be provided at Rutgers University, a public institution that trains over 700 postdoctoral fellows each year. Finally and most importantly, this Training Program will support the education and research environment at three public institutions, Medgar Evers College – CUNY, New Jersey City University, NJ, and William Paterson University, NJ, that have a demonstrated commitment to educating undergraduate students from groups underrepresented in biomedical research careers.

PI_NAMEs: BOISON, DETLEV ;BREWER, GARY A.;SOTO, MARTHA C. (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Awareness;Biomedical Research;career;career development;Cities;Collaborations;college;course development;curriculum development;Education;Educational process of instructing;Faculty;Funding;Goals;improved;innovation;Institution;Laboratories;Measures;medical schools;Mentors;Modeling;New Jersey;next generation;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Program Development;Program Evaluation;programs;recruit;Research;research faculty;Research Training;Schools;Science;Scientist;STEM field;Structure;student participation;Students;success;summer research;Training;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Students;Universities;Wood material;Writing

PROJECT_TITLE: IRACDA at Rutgers: INSPIRE Postdoctoral Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF ARIZONA

PI_NAMEs: SCHORK, NICHOLAS JOSEPH (contact)

PROJECT_TERMS: Address;age related;Age-associated memory impairment;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Assessment tool;Behavior Therapy;Biological Assay;Biological Markers;Biometry;brain health;care providers;causal model;Cellular Phone;Classification;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;Collection;combat;Data;Data Analyses;data integration;Data Science Core;Data Set;Decision Trees;design;Development;Dietary Intervention;drug development;Drug Targeting;Early Diagnosis;Environmental Risk Factor;Exhibits;functional decline;Future;Gene Expression Profile;Genetic;genome wide association study;Genotype-Tissue Expression Project;Goals;handheld mobile device;Health;healthspan;Heterogeneity;Human;human old age (65+);Impaired cognition;improved;Individual;individual variation;Informatics;insight;Internet;Intervention;Intervention Studies;Intervention Trial;life span;lifestyle factors;Light;Maintenance;Measures;Mediation;member;Mendelian randomization;Meta-Analysis;Methodology;Methods;model building;Modeling;Molecular;Molecular Profiling;Monitor;multimodality;Nature;Network Infrastructure;neuroimaging;Nomograms;novel;Older Population;Pathway interactions;Patients;Performance;Personal Satisfaction;personalized intervention;pharmacologic;Physical Function;Physiological;Physiology;predictive modeling;preservation;prevent;Preventive;prognostic model;Protocols documentation;prototype;Psychometrics;Public Domains;Public Health;Research;Research Design;Research Personnel;Risk;Risk Assessment;risk prediction model;Sampling;Services;smartphone application;social factors;Sorting;Source;Subgroup;Systems Biology;Techniques;Technology;technology intervention;Testing;Theoretical model;Therapeutic;therapeutic target;therapy development;Tissues;Treatment Efficacy;trial design;web-based intervention;Work

PROJECT_TITLE: Project 4:  Precision Methods for Assessing Brain Health and Age-related Cognitive Impairment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research

PI_NAMEs: JOHN, SAMANTHA E. (contact)

PROJECT_TERMS: African American;African American population;Alzheimer's Disease;Applications Grants;Behavioral Symptoms;Biological Markers;Caregiver Burden;Caregivers;Caucasians;Centers of Research Excellence;clinical outcome measures;Clinical Trials;Cognition;Communities;comorbidity;daily functioning;Data;design;Development;Diagnosis;Disadvantaged;Discrimination;Disease;Doctor of Philosophy;Equity;ethnic diversity;ethnoracial;ethnoracial minority;Exposure to;Focus Groups;Funding;Future;Goals;Health Personnel;Health Status;Healthcare;Hispanic;Hispanic Americans;Hispanic Populations;improved;Individual;Intervention;lifestyle factors;Measurement;Measures;Methods;minority patient;Monitor;Nerve Degeneration;Neurodegenerative Disorders;older adult;Outcome;Outcome Measure;Participant;Pathology;patient engagement;Patient Outcomes Assessments;patient retention;patient safety;Patient-Focused Outcomes;Patients;Pattern;Perception;Pharmaceutical Preparations;Phase;Population Heterogeneity;preference;Property;Psychometrics;public health priorities;Quality of life;racial diversity;reduce symptoms;Reporting;Research;research study;response;Risk;Sampling;social;social disparities;Source;Surveys;Symptoms;Systematic Bias;translational neuroscience;treatment adherence;Treatment Efficacy

PROJECT_TITLE: Project 2


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Machine Learning and Artificial Intelligence;Neurosciences;Prevention;Rehabilitation

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: NARRATIVE Hearing loss is one of the leading causes of disability in America. Many profoundly deaf adults significantly benefit from cochlear implantation, but the hearing outcomes following this procedure are highly variable. The proposed study aims to investigate audiovisual integration and cortical plasticity in cochlear implant users to better understand and predict cochlear implant outcomes.

PI_NAMEs: KUNNATH, ANSLEY  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adult;Affect;Age;American;audiovisual speech;Auditory;Auditory area;Behavioral;Brain;Brain region;Clinical;Clinical Data;Cochlear implant procedure;Cochlear Implants;Comprehension;Cueing for speech;Cues;Data;deaf;deafness;Devices;disability;Electrodes;Electroencephalography;Environment;Exhibits;expectation;experimental study;Fellowship;functional near infrared spectroscopy;Future;Hearing;hearing impairment;hearing restoration;implantation;improved;Individual;innovation;insight;interest;Intervention;Laboratory Finding;Machine Learning;machine learning model;machine learning prediction algorithm;Magnetic Resonance Imaging;Measures;Modality;Modeling;Morphologic artifacts;multisensory;neural correlate;neuroimaging;neuroprosthesis;Neurosciences;normal hearing;novel;Operative Surgical Procedures;Otolaryngology;Outcome;Patients;Pattern;Perception;Performance;Persons;Phonetics;Physicians;Play;Positioning Attribute;Predictive Factor;predictive modeling;predictive tools;preimplantation;Procedures;prognostic value;random forest;regression algorithm;Research;response;Role;Scientist;Sensorineural Hearing Loss;Sensory;sensory cortex;sensory integration;Sensory Process;Speech;Speech Perception;speech recognition;speech synthesis;Standardization;Stimulus;success;Superior temporal gyrus;support vector machine;surgery outcome;theories;Time;Visual;Visual Cortex;visual performance;visual processing;visual speech

PROJECT_TITLE: Multisensory Integration and Cortical Plasticity in Cochlear Implant Users


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

ORG_CITY: MANHATTAN

ORG_DEPT: NUTRITION

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: Project Narrative Kansas State University will partner with three community colleges in southwest Kansas to continue a highly successful Bridges to the Future Baccalaureate program under the new T34 funding mechanism. The overall purpose of K-State's Bridges program is to increase the number of underrepresented students with baccalaureate degrees in biomedical, clinical, behavioral and social sciences, and to set into motion pathways designed to increase the number of PhDs, MDs, and other professional doctorates in those fields. Our proposal will provide authentic research experiences within biomedical science labs, additional research training and mentoring, and professional skills development in an inclusive and supportive environment in order to assist the National Institutes of Health in recruiting talented individuals with unique perspectives and experiences to the biomedical workforce.

PI_NAMEs: BEHNKE, BRAD J (contact);JORDAN, SHAWNA

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;Agriculture;Associate Degree;Bachelor's Degree;behavioral and social science;Biomedical Research;biomedical scientist;bridge program;bridge to the baccalaureate;career;Cities;Clinical;college;community college;Complex;cost;Country;County;Education Projects;Educational workshop;Enrollment;Ensure;experience;Family;First Generation College Students;Funding;Funding Mechanisms;Future;Goals;Grant;Health;health disparity;Hour;Immigrant family;Individual;Industry;Internships;Kansas;laboratory experience;Language;matriculation;Meat;Mentors;migration;Pathway interactions;Plants;programs;public trust;recruit;Research;Research Training;Scholars Program;Scholarship;Solid;Spanish;STEM field;Students;Talents;Training;Training Programs;undergraduate research experience;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at Kansas State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The interaction between kelch-like ECH-associating protein 1 (Keap1) and nuclear factor (erythroid-derived 2)- like 2 (Nrf2), a key regulator of cellular redox homeostasis, has been studied as a potential drug target for neurodegenerative diseases, such as Alzheimer’s Disease, in which aging and oxidative stress play a central role. Current developments are limited by specificity, bioactivity, and pharmacokinetic properties, creating a need for clinically translatable Keap1-inhibiting/Nrf2-inducing therapeutics. This proposal seeks to address these challenges by utilizing a novel peptide delivery system that allows for the protected delivery of Nrf2 inducing peptides either alone or with the addition of other functional motifs through the protein-like polymer platform.

PI_NAMEs: CARROW, KENDAL PAIGE (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Address;Affinity;Age;Age related pathologies;Aging;aging population;Alzheimer's Disease;Antioxidants;Attention;Automobile Driving;Autophagocytosis;Binding;Binding Sites;Biogenesis;Biological;Biological Assay;biomaterial compatibility;Biomimetics;career;Cells;Central Nervous System;Central Nervous System Diseases;Chemicals;Chemistry;Chimera organism;Clinical;Clinical Skills;clinical translation;copolymer;density;design;Development;dimer;Drug Kinetics;Drug Targeting;Equipment;Erythroid;Evaluation;Excision;Exhibits;Flow Cytometry;Fostering;Half-Life;hemocompatibility;HepG2;Homeostasis;Hydrophobicity;immunogenicity;improved;in silico;In Vitro;in vivo;in vivo evaluation;Inflammation;inhibitor;insight;interest;Length;materials science;mimetics;Mitochondria;Modeling;Molecular Weight;Morbidity - disease rate;Morphology;mortality;Mus;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;neuroprotection;novel;novel therapeutics;Nuclear;Outcome;Oxidation-Reduction;Oxidative Stress;Pathologic;Pathway interactions;Penetration;peptide drug;Peptides;Performance;Permeability;Pharmaceutical Preparations;Physicians;Play;polymerization;Polymers;Preparation;Property;protein aminoacid sequence;protein degradation;protein protein interaction;Proteins;Proteolysis;Reporter;Reporter Genes;Research;Research Personnel;Resistance;response;Response Elements;Role;Scientist;sensor;small molecule;Specificity;Stress;Structure;System;targeted treatment;Technical Expertise;Therapeutic;therapeutic target;tool;Toxic effect;Training;transcription factor;Transgenic Organisms;translational therapeutics;Universities;uptake;Western Blotting;Wisconsin;Work

PROJECT_TITLE: Development of Protein Like Polymer Therapeutics for Modulating the Nrf2/Keap1 Protein Protein Interaction in Neurodegenerative Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Robust data are required to investigate the impact of technology and digital media (TDM) use on preschool children’s health and development outcomes. Novel, passive, objective assessments of young children’s TDM use will be combined with state-of-the art measurements of children’s sleep and executive function tasks, to identify the influence of TDM use on children’s weight status, sleep, and development over the short- and long-term (12 months). Findings will provide stronger evidence to inform future guidelines for children’s TDM use.

PI_NAMEs: O'CONNOR, TERESIA MARGARETA (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 4 year old;5 year old;8 year old;Academy;Address;Adverse effects;American;Assessment tool;Behavioral;Biometry;Child;Child Development;Child Health;Child Rearing;Childhood;Circadian Rhythms;Cognitive;cohort;Collaborations;Communication;computer game;computerized data processing;Computers;cost effective;Data;data harmonization;data integration;data management;Database Management Systems;Databases;Development;digital;digital assessment;digital media;Education;Environmental Risk Factor;Ethnic Origin;executive function;Experimental Designs;experimental study;Exposure to;Face;Family;Funding;Future;gaze;Guidelines;handheld mobile device;Health;Health behavior;Home;Home environment;Hour;improved;Interdisciplinary Study;Internet;Label;Link;Longitudinal cohort;machine learning algorithm;Measurement;Measures;media use;Mediating;Methodology;Methods;new technology;novel;novel strategies;Nursery Schools;Obesity;obesity risk;Outcome;parent project;Parent-Child Relations;parental role;Parents;Pediatrics;Play;Positioning Attribute;Preschool Child;Process;programs;Race;Recommendation;recruit;Reporting;Research;Risk Factors;Role;Sampling;scaffold;School-Age Population;Science;sex variable;Sleep;Sleep Disorders;Structure;synergism;System;systematic review;Technology;Technology Assessment;Testing;Time;tool;tv watching;Video Games;Weight

PROJECT_TITLE: Leveraging passive objective assessment methods of preschooler's media use to examine multiple paths of influence on sleep, executive function and weight status


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Childhood Obesity;Clinical Research;Obesity;Pediatric;Prevention;Sleep Research

PROJECT_TERMS: 4 year old;8 year old;Accounting;Address;adequate sleep;Affect;Android;Behavior Therapy;Biometry;Body mass index;cardiovascular risk factor;Child;Child Rearing;Code;cohort;computer game;cost effectiveness;Cross-Sectional Studies;Data;Database Management Systems;Databases;Development;Devices;Dietary intake;digital;digital assessment;digital media;Disease;Ensure;Environment;Equipment and supply inventories;executive function;expectation;Exposure to;Face;Family;Funding;Future;gaze;Grant;Guidelines;handheld mobile device;Health;Health behavior;healthy weight;Height;high risk;Home;Home environment;Hour;improved;Intervention;Investigation;Left;Link;Longitudinal Studies;Longitudinal, observational study;machine learning algorithm;Measures;media use;Mediating;Mediator;Methodology;Methods;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;neighborhood safety;Neighborhoods;new technology;novel;novel strategies;Nursery Schools;Obesity;obesity risk;Outcome;Overweight;Parents;Pathway interactions;Physical activity;Play;poor sleep;Positioning Attribute;Preschool Child;Process;programs;Recommendation;Reporting;Research Design;Risk;Sampling;School-Age Population;sedentary lifestyle;Services;Sleep;Sleep Disorders;sleep health;sleep quality;Social Environment;Stream;synergism;System;systematic review;Technology;Technology Assessment;technology platform;Time;time use;Video Games;Weight;Wrist

PROJECT_TITLE: Technology and digital media's influence on preschool children's sleep and weight status


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Genomic instability is a hallmark of many disease conditions, including cancers, and is often caused by replication defects. Our work aims understand in greater detail the varied mechanisms by which cells respond to replication stress by studying the interplay between RNA dependent processes and DNA replication integrity. Adequately understanding these processes will improve our understanding of the molecular underpinnings of genome maintenance and provide critical novel insights that can be exploited in novel therapeutic approaches.

PI_NAMEs: ADEYEMI, RICHARD  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: assault;biochemical tools;biological adaptation to stress;cancer therapy;Cell Line;Cells;Characteristics;Chromatin;Complex;Data Set;Defect;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;DNA-Directed DNA Polymerase;Dose;Enzymes;Exposure to;Genes;Genetic;Genome;Genome Stability;Genomic Instability;Grant;improved;insight;Link;Maintenance;Malignant Neoplasms;Molecular;Mutation;novel;novel therapeutic intervention;Nucleotide Biosynthesis;Organism;Pathogenesis;Pathway interactions;Postdoctoral Fellow;Process;Regulation;repaired;replication stress;Research Project Grants;Resources;response;restoration;RNA;RNA Binding;RNA Helicase;Role;Single-Stranded DNA;Source;SS DNA BP;Untranslated RNA;whole genome;Work

PROJECT_TITLE: Mechanistic Characterization of the Replication Stress Response

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC FOUNDATION

PI_NAMEs: KINNEY, JEFFERSON  (contact)

PROJECT_TITLE: Core E - Translational Biomarker Core