ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative The goal of this project is to provide biostatistical leadership and data management infrastructure for the BLOODSAFE initiative, an NHLBI initiative which seeks to increase the supply of safe blood available for transfusion in Sub-Saharan Africa. This leadership includes coordination of activities across multiple projects, collaboration with scientists at NHLBI on program oversight and provision of expertise regarding all aspects of study design and implementation. This expertise includes but is not limited to coordination with local experts, provision of training to local experts, assistance with study design, harmonization of data elements across multiple studies, assistance with implementation of interventions, data management, data quality assurance, data analysis and study finding dissemination to ensure that discoveries are communicated to the scientific community and translated into local best practices in a timely manner.

PI_NAMEs: REILLY, CAVAN S. (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acute;Africa;Africa South of the Sahara;Anemia;Biometry;Blood;blood product;Blood Transfusion;Child;clinical investigation;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communication;Communities;Conflict (Psychology);Data;Data Analyses;data centers;Data Collection;Data Coordinating Center;Data Element;data harmonization;data management;data quality;data standards;Democratic Republic of the Congo;design;Development;Discipline of obstetrics;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Ensure;Epidemic;experience;Fire - disasters;genome wide association study;Goals;Hemorrhage;implementation intervention;Improve Access;improved;Information Dissemination;Infrastructure;instrument;International;Laboratories;Leadership;Liberia;Liberian;Malaria;Medicine;Minnesota;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Observational Study;Outcome;Participant;Pathology;Policies;Principal Investigator;programs;protocol development;public health emergency;quality assurance;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;research study;Resistance;response;Science;Scientist;Sickle Cell Anemia;Specimen;System;Therapeutic;Training;training opportunity;Transfusion;Translating;United States;Universities;Vulnerable Populations;Woman;Work;World Health Organization

PROJECT_TITLE: The BLOODSAFE Data Coordinating Center: A Data Center for More SafeTransfusions in Sub-Saharan Africa


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Telehealth

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE HIV incidence remains high among men who have sex with men (MSM) in Perú, and has not significantly changed despite the scale-up of antiretroviral treatment access over the last decade. New strategies are needed to increase access to HIV testing and promote timely linkage to treatment and prevention services in this population. In this project, we will develop, refine, and conduct feasibility testing of a multi-component intervention to support HIV testing and linkage to services among MSM in Perú.

PI_NAMEs: LANKOWSKI, ALEXANDER JULIAN (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;AIDS prevention;Alcohol consumption;antiretroviral therapy;Area;Attitude;Automation;Automobile Driving;barrier to care;career;career development;Caring;Clinic;Clinical Research;Communities;comparative;Complement;Consolidated Framework for Implementation Research;Continuity of Patient Care;cost;Development;Development Plans;Diagnosis;digital;Elements;evidence base;experience;Exposure to;feasibility testing;feasibility trial;field study;Focus Groups;Goals;Health Personnel;Health Services Accessibility;HIV;HIV diagnosis;HIV Infections;HIV Seronegativity;Home;Hour;Human immunodeficiency virus test;implementation barriers;implementation facilitators;implementation science;improved;Incidence;Individual;Institution;International;Intervention;Intervention Trial;Interview;Language;Link;Logistics;men who have sex with men;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mHealth;multi-component intervention;multidisciplinary;Multimedia;Nature;Newly Diagnosed;novel;Outcome;Output;outreach;Participant;Peru;point of care testing;Population;Positioning Attribute;pre-exposure prophylaxis;preference;Prevention;prevention service;primary outcome;Privacy;Provider;Quantitative Evaluations;Random Allocation;recruit;Research;Research Personnel;Resources;Risk;Sauna;scale up;Scheme;secondary outcome;Security;self testing;service intervention;Services;sex;sexual risk behavior;Site;social;Spanish;Standardization;Structure;Target Populations;Technology;Testing;Text;theories;therapy development;Training;transmission process;treatment services;two way texting;uptake;usability;Vulnerable Populations;web portal;Work

PROJECT_TITLE: Development and Feasibility Testing of a Multi-Component Intervention to Increase HIV Testing and Linkage to Services among MSM in Peru

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PI_NAMEs: CHEN, YIDONG  (contact)

PROJECT_TERMS: Acceleration;Accountability;Adopted;Adoption;analytical method;analytical tool;anti-cancer research;Area;Basic Science;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical data science;Biometry;Cancer Center;Cancer Etiology;cancer health disparity;Catchment Area;Cells;Child;Clinical;clinical application;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Database;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Collection;Complex;computing resources;Conduct Clinical Trials;cost efficient;Data;Data Analyses;Data Collection;data de-identification;data integration;data management;data resource;Data Science;data sharing;Data Sources;Data Storage and Retrieval;design;Development;Doctor of Medicine;Doctor of Philosophy;Education;Ensure;Evaluation;experience;Experimental Designs;Faculty;faculty support;flexibility;Fostering;Funding;Genetic;genomic data;genomic tools;Genomics;Goals;Health;High Performance Computing;High-Throughput Nucleotide Sequencing;improved;Individual;Information Services;Information Systems;Infrastructure;innovation;instrument;Investigation;Location;Malignant Neoplasms;Manuscripts;medical schools;member;Mentorship;Methods;molecular diagnostics;Monitor;next generation sequencing;novel;novel therapeutics;Online Systems;operation;Outcome;Peer Review;Performance;Phenotype;Pilot Projects;Population Research;Population Study;Preparation;Procedures;Process;Production;Productivity;programs;Proteomics;protocol development;Protocols documentation;Publications;Quality Control;Reporting;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Safety;screening;Services;square foot;Statistical Data Interpretation;survival outcome;System;Techniques;Testing;Texas;tool;tool development;Training;Training and Education;translational applications;translational genomics;Translational Research;Treatment outcome;treatment trial;Universities;Work

PROJECT_TITLE: Mays Cancer Center at UT Health SA

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: HEALTH RELEVANCE STATEMENT Cocaine Use Disorder (CUD) is a significant public health and socioeconomic concern, but genetic factors that contribute to development of CUD remain poorly understood. Genetic studies of CUD are difficult to perform in humans due to inability to control environmental factors; the haplotype structure of the human genome limiting mapping precision; and small sample sizes as a result of difficulty recruiting participants due to the criminalization of cocaine use. I will take advantage of the fruit fly Drosophila melanogaster, a powerful genetic model organism, to identify genetic variants associated with development of cocaine preference and construct genetic networks that can serve as a gene discovery template for candidate genes associated with human CUD.

PI_NAMEs: HATFIELD, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Acute;advanced system;Affect;Alleles;Animal Model;Animals;behavior test;Behavioral;Behavioral Assay;Binding;Biological Assay;Blood capillaries;Brain;Candidate Disease Gene;candidate validation;career;Chromosome Mapping;Cocaine;cocaine exposure;cocaine overdose;cocaine self-administration;cocaine use;Cocaine use disorder;Collection;Consumption;cost;cost effective;Data;Development;dopamine transporter;Drosophila genus;Drosophila melanogaster;Emergency department visit;Environment;Environmental Risk Factor;Exhibits;follow-up;gene discovery;Genes;Genetic;genetic analysis;genetic approach;Genetic Models;Genetic study;Genetic Techniques;genetic variant;genome wide association study;Goals;Grooming;Haplotypes;Health;health economics;Heritability;Human;Human Genome;Hyperactivity;Inbreeding;knock-down;Libraries;Locomotion;Maps;Measures;Mediating;Methods;model organism;novel;Ontology;Pathway interactions;Patient Recruitments;Pharmaceutical Preparations;Phenotype;Population;preference;Public Health;RNA;RNA Interference;Sample Size;Sampling;screening;Seizures;Self Administration;sexual dimorphism;socioeconomics;Structure;Substance Use Disorder;System;Testing;Training;trait;transcriptome sequencing;transcriptomics;translational potential;Twin Studies;United States;validation studies;Variant;whole genome

PROJECT_TITLE: Systems Genetics of Cocaine Preference in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Vaccines are necessary to protect against harmful pathogens; however, their development has typically been empiric and their approval based on clinical, not immunological outcomes. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) mRNA vaccines demonstrate varied efficacy across age and time post-vaccination, highlighting our lack of understanding of how, where, and in what quantity vaccine-specific immunity is induced. This proposed work will fill these gaps in knowledge so that more effective prevention strategies can be developed to manage the current pandemic and any future health crises.

PI_NAMEs: DAVIS-PORADA, JULIA MEGHAN (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adult;Affect;Age;age difference;Antibody Formation;Antibody titer measurement;Attenuated;Authorization documentation;B-Lymphocytes;Blood;Blood specimen;Cell Physiology;Cells;Child;Clinical;Collaborations;Communities;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;current pandemic;cytokine;Data;Development;Enzyme-Linked Immunosorbent Assay;Event;Exhibits;Flow Cytometry;Frequencies;frontier;Future;Goals;Health;high dimensionality;Human;human tissue;Humoral Immunities;Immune;Immune system;Immunity;Immunologic Memory;improved;Individual;Infection;Inflammatory;Integration Host Factors;Interferons;Investigation;Knowledge;Laboratories;Life;Lung;lymph nodes;Lymphocyte;Lymphoid;lymphoid organ;Lymphoid Tissue;Macrophage;Maintenance;manufacture;Measures;Mediating;Medical;Memory;Memory B-Lymphocyte;Modeling;Moderna COVID-19 vaccine;Monitor;Mononuclear;Morbidity - disease rate;mortality;Mucous Membrane;Natural Immunity;neutralizing antibody;novel;novel vaccines;Organ Donor;Organ Procurements;Outcome;pandemic disease;pathogen;Persons;Phenotype;Population;prevent;Prevention strategy;Production;Property;Proteins;quantitative imaging;Residencies;Resources;respiratory virus;response;RNA vaccine;Role;Serology;severe COVID-19;Site;Spatial Distribution;T memory cell;T-Lymphocyte;Time;Tissue Donors;tissue resource;Tissues;unvaccinated;Vaccinated;Vaccination;Vaccine Design;vaccine development;vaccine distribution;vaccine efficacy;vaccine formulation;vaccine immunogenicity;vaccine response;vaccine strategy;vaccine trial;vaccine-induced immunity;Vaccinee;Vaccines;vaccinology;Variant;Viral;Virus;Virus Diseases;Work

PROJECT_TITLE: Induction and maintenance of SARS-CoV-2 mRNA vaccine-specific memory across tissues


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Acute allograft rejection is a T cell mediated immune response that continues to undermine heart transplant outcomes. Endogenous (pre-existing) memory T cells infiltrate cardiac allografts early after graft reperfusion and the proposed experiments will test the mechanisms by which these memory T cells are activated to mediate increased graft tissue injury and rejection of allografts subjected to prolonged cold ischemic storage. Findings from these studies should reveal new therapeutic targets to dampen early post-transplant inflammation and inhibit endogenous memory CD8 T cell-mediated acute graft injury and rejection of high-risk allografts in unsensitized recipients.

PI_NAMEs: KORITZINSKY, ERIK HARRISON (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;Adoption;Allogenic;allograft rejection;Allografting;Antigens;Blood Transfusion;Calcineurin inhibitor;Cardiovascular system;CD8-Positive T-Lymphocytes;cell free DNA;cell mediated immune response;Cells;Chronic;Circulation;Clinic;Clinical;Clinical Trials;clinically relevant;cohort;Complex;cross reactivity;CTLA4-Ig;cytokine;Data;Disease;early detection biomarkers;effective therapy;Endothelial Cells;Environment;Epidermal Growth Factor Receptor;Event;experimental study;Exposure to;Generations;Goals;graft function;Graft Survival;heart allograft;Heart Transplantation;high risk;Immune;immune activation;Immunity;Immunosuppression;improved;improved outcome;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;injured;Injury;insight;interest;Interferon alpha;Interferon Type I;Interferons;Interleukin-1 beta;Interleukin-6;Ischemia;Kidney;Kidney Transplantation;Length;Leukocytes;Link;Maintenance;Mediating;Memory;Mitochondrial DNA;Modeling;Molecular;Mus;Myeloid Cell Activation;new therapeutic target;novel;novel strategies;Organ;Organ Transplantation;Outcome;pathogen;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;pharmacologic;Phase;post-transplant;Pregnancy;Process;Production;Proliferating;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Resistance;response;Risk;Risk Factors;sensor;Series;side effect;Signal Transduction;Solid;T cell infiltration;T memory cell;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Time;Tissue Grafts;tissue injury;Tissues;TNF gene;Toxic effect;transplant model;Transplant Recipients;Transplantation;type I interferon receptor;Vascularization;Work

PROJECT_TITLE: Endogenous memory T cell mediated rejection of high-risk cardiac allografts


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BERTON, MICHAEL T (contact)

PROJECT_TERMS: Adoption;Advisory Committees;Applications Grants;Area;Award;Budgets;Cancer Center;Caspase;Cell Cycle;Cell Separation;Cells;Certification;Clone Cells;Computer Analysis;Computer software;Computer Workstations;Consultations;cost effective;Cytometry;Data;Data Analyses;dimensional analysis;Doctor of Philosophy;Dyes;Equipment;equipment acquisition;Experimental Designs;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Genomics;Grant;Group Meetings;Health;high standard;Immunology;improved;Institution;instrument;Laboratories;Malignant Neoplasms;Manuscripts;Measurement;member;Methods;Microbiology;mid-career faculty;Mission;Mitochondria;Molecular Genetics;Molecular Medicine;new technology;Nitrogen;operation;Oxygen;Peer Review;Preparation;Production;Productivity;programs;Publications;Reporting;Research;Research Personnel;Resource Sharing;Series;Services;Sorting;square foot;Technical Expertise;Technology;Texas;Training;Training and Education;Training Programs;transcriptomics;Universities;Writing


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: WEINTRAUB, SUSAN T (contact)

PROJECT_TERMS: American;anti-cancer research;Applications Grants;Cancer Center;Cells;Complex;Computer software;Consult;Consultations;Data;Data Analyses;detection limit;Doctor of Philosophy;Drug Binding Site;Educational workshop;Equipment;Evaluation;experience;Experimental Designs;experimental group;Funding;Grant;Health;innovation;instrument;instrumentation;interest;Investigation;Laboratories;Leadership;Malignant Neoplasms;mass spectrometer;mass spectrometry shared resource;Mass Spectrum Analysis;member;Mission;Modification;molecular mass;new technology;Peer Review;Peptides;Post-Translational Protein Processing;Preparation;protein expression;Proteins;Proteomics;Recombinant Proteins;Research;Research Personnel;Resource Sharing;Role;Sampling;Services;Signal Pathway;Site;small molecule;Societies;square foot;System;Texas;Tissue Sample;Training;United States National Institutes of Health;Universities


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Effort-cost decision-making (ECDM) deficits are core to schizophrenia (SZ) and associated with poor functional outcomes. The proposed project seeks to integrate lab-based behavioral and neuroimaging paradigms with real- world measures of social motivation to investigate whether and how social influence may enhance ECDM in SZ. This project, which would provide the candidate with valuable training opportunities towards her goals as an independent researcher, could elucidate mechanisms at the intersection of social and motivational processes in SZ and pave the way for targeted interventions for these debilitating impairments.

PI_NAMEs: MERCHANT, JAISAL TAARA (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Agreement;Anhedonia;Anterior;base;Behavioral;cingulate cortex;Clinical assessments;Collection;contextual factors;cost;Decision Making;design;Development;Disease;Ecological momentary assessment;Expenditure;Frequencies;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;Goals;high reward;Impairment;Individual;Individual Differences;Influentials;interest;Intervention;Laboratories;Life;Link;Literature;Measures;Methods;motivated behavior;Motivation;motivational processes;multimodality;Nature;neural;neural circuit;neural correlate;neuroimaging;Occupational;Participant;peer;peer influence;Performance;pleasure;Population;Prefrontal Cortex;Principal Investigator;Probability;Reporting;Reproducibility;Research;Research Methodology;Research Personnel;Resources;response;Rewards;Role;Schizophrenia;social;Social Environment;social factors;social influence;Social Interaction;Social Processes;social relationships;Suggestion;Symptoms;System;Techniques;Time;tool;Training;training opportunity;Ventral Striatum;Work

PROJECT_TITLE: The Effect of Social Influence on Effort-Cost Decision-Making in Schizophrenia: From Mechanisms to Real-World Associations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major public health burden, with no therapy that reliably prevents or treats it. Abundant data from animal models and humans suggest that hepcidin and other heme/iron regulatory proteins play a key role in CSA-AKI. We will investigate circulating levels and cellular expression of heme/iron regulatory proteins to assess whether they are risk factors and early markers of CSA-AKI, and could serve as therapeutic targets for CSA-AKI prevention in future trials.

PI_NAMEs: LEAF, DAVID EVAN (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Affect;Agonist;animal data;Animal Model;Attenuated;biobank;Boston;Cardiac Surgery procedures;Cardiac Volume;Cardiopulmonary Bypass;Case/Control Studies;cell type;Circulation;Clinical Data;Clinical Trials;Complex;Critical Illness;Data;design;Development;Enrollment;experience;Ferritin;Flow Cytometry;Future;genetic regulatory protein;Genomics;Haptoglobins;Heme;Hemoglobin;Hemolysis;Hemopexin;Hepatocyte;hepcidin;high risk;Homeostasis;Hormones;Hospitals;Human;human data;Incidence;Inflammation;Infrastructure;injury prevention;innovation;Interleukin-6;Investigation;Iron;Iron Metabolism Disorders;Iron-Regulatory Proteins;Measures;metal transporting protein 1;Modeling;monocyte;mortality;North America;novel;oxidative damage;participant enrollment;Pathogenesis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;Plasma;Play;Postoperative Period;prevent;prophylactic;Prospective, cohort study;protein expression;Proteins;Public Health;research study;Risk;Risk Factors;Role;Sampling;Serum;Site;SLC11A2 gene;success;Testing;Therapeutic;therapeutic target;Time;Transferrin;translational immunology;uptake;Variant

PROJECT_TITLE: Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


PI_NAMEs: HART, MATTHEW JOHN (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Antineoplastic Agents;Area;Biological Assay;Cancer Center;Cancer Etiology;cancer therapy;Cells;Clinical;Communication;Complex;Consultations;Core Facility;cost;Crystallization;Data;data acquisition;Data Analyses;data visualization;design;Doctor of Philosophy;drug candidate;drug discovery;drug resource;Drug Screening;Educational workshop;Evaluation;experience;Experimental Designs;Fluorescent Probes;Funding;Future;Generations;Goals;Health;high throughput screening;Image;Individual;Institution;instrumentation;Isotope Labeling;Kinetics;Knowledge;Lead;lead optimization;Ligands;Logistics;macromolecule;Magnetism;Maintenance;Malignant Neoplasms;member;Mission;Molecular;molecular phenotype;Molecular Structure;Monitor;novel;novel therapeutics;Nuclear;Nuclear Magnetic Resonance;operation;Performance;Phase;Phenotype;pre-clinical;Process;Production;Protein Analysis;Proteins;Publications;Recommendation;Reporting;Research;Research Design;Research Personnel;Resource Sharing;Roentgen Rays;screening;Services;small molecule;small molecule libraries;stoichiometry;structural biology;Structure;Surface Plasmon Resonance;symposium;Techniques;Technology;Testing;Therapeutic;Thermodynamics;Time;timeline;tool;Training;Training and Education;Translating;Translations;Work;X ray spectroscopy;X-Ray Crystallography


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Rickettsia species are intracellular bacterial pathogens that cause mild to deadly vascular diseases in humans. Our overall goal in this project is to determine how a secretion system and secreted bacterial proteins hijack host cell function to promote pathogenesis. This work will improve our understanding of Rickettsia pathogenesis, provide insights into host cell biology, and may lead to improved diagnostics or treatments for infection.

PI_NAMEs: LAMASON, REBECCA L (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Ankyrin Repeat;Bacterial Infections;Bacterial Proteins;Biochemical;Biological;Biological Assay;Biology;Cell Adhesion Molecules;cell fixing;Cell Physiology;Cell-Cell Adhesion;Cells;Cellular biology;Cessation of life;combat;Complement;Complex;Cytosol;design;Development;Diagnostic;Ectopic Expression;Exanthema;forward genetics;Future;Genes;Genetic;genetic approach;genetic manipulation;Genetic study;Genetic Variation;Goals;Human;Impairment;improved;Infection;insight;Integration Host Factors;Intercellular Junctions;interest;Invaded;Label;Laboratories;Life;Life Cycle Stages;Location;Mediating;member;Metabolic;Microscopy;Modeling;Modernization;Molecular;Mutagenesis;mutant;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Phase;Plasmids;prevent;programs;Property;Protein Secretion;Proteins;Proteomics;Research;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Site;spotted fever;Structure;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;tick-borne;Tick-Borne Diseases;Tick-Borne Infections;Time;tool;Type IV Secretion System Pathway;United States National Institutes of Health;Vascular Diseases;Vinculin;Widespread Disease;Work

PROJECT_TITLE: Mechanisms of SFG Rickettsia-Host Interactions

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative The medial prefrontal cortex governs many aspects of cognitive control and is hypothesized to play a major role in individual differences in cognitive function both before and after alcohol exposure that drive maladaptive behaviors that characterize alcohol use disorder (AUD). The focus of this proposal is to gain insight into the contribution of a population of prefrontal cortical neurons that project to the midbrain in preexisting and alcohol induced cognitive dysfunction in order to understand more about this specific pathway in the vulnerability of AUD development. This research addresses a critical gap in knowledge regarding the cognitive factors that predispose certain individuals over others to AUD development.

PI_NAMEs: KANDOV, EVELYN  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: addiction;Address;Affect;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol exposure;alcohol use disorder;Alcohols;American;Area;Behavior;Behavioral;Behavioral Assay;Behavioral Paradigm;binge drinking;brain circuitry;Calcium;Caring;Cells;Cognitive;cognitive change;cognitive control;Cognitive deficits;cognitive function;cognitive performance;Complex;Corpus striatum structure;design;Development;discrimination task;Disease;disease model;Endoscopy;Event;Exhibits;Exposure to;flexibility;Functional Magnetic Resonance Imaging;Future;Glutamates;Goals;Head;Health;Human;human data;Image;Impaired cognition;Impairment;Implant;in vivo;in vivo calcium imaging;Individual;Individual Differences;insight;interest;Internet;Investigation;Knowledge;Learning;Maintenance;maladaptive behavior;Measures;Medial;Mediating;microendoscope;Microscope;Midbrain structure;Morbidity - disease rate;mortality;Mus;Neural Pathways;neuroimaging;Neurons;Pathway interactions;Pattern;Performance;Persons;Phase;Play;Population;Positive Reinforcements;Predisposing Factor;Predisposition;Prefrontal Cortex;Preventive measure;Quality of life;Research;Research Personnel;Resolution;response;Reversal Learning;reward processing;Risk Factors;Role;Running;Signal Transduction;Source;Stimulus;Structure;Techniques;Testing;Time;Training;United States;Variant;Ventral Tegmental Area;Viral

PROJECT_TITLE: Role of Prefrontal Cortical Projections to the Midbrain in Alcohol-Induced Cognitive Deficits in Mice


PI_NAMEs: LAI, ZHAO  (contact)

PROJECT_TERMS: Advisory Committees;anti-cancer research;Applications Grants;Area;Base Sequence;Bioinformatics;Bioinformatics Shared Resource;Biological Assay;Biometry;cancer cell;Cancer Center;Cancer Center Support Grant;cancer heterogeneity;cancer initiation;Catchment Area;Cells;Child;ChIP-seq;chromatin modification;Chromosome Structures;Chromosomes;Collaborations;Complement;Consultations;Copy Number Polymorphism;cost effective;CRISPR screen;Data;data pipeline;Diagnosis;DNA copy number;DNA Damage;DNA sequencing;Doctor of Philosophy;Educational workshop;Environment;Equipment;Experimental Designs;Faculty;Funding;Funding Agency;Future;Gene Expression;Gene Expression Regulation;Generations;genomic data;Genomics;Goals;Group Meetings;Health;improved;Journals;Knowledge;Libraries;Link;liquid biopsy;Malignant Neoplasms;Manuscripts;member;Metagenomics;MicroRNAs;Mission;Nature;next generation sequencing;novel;Pathway interactions;Peer Review;Phenotype;Population;Preparation;Price;Prognosis;programs;Protocols documentation;Publications;rare variant;Reagent;Research;Research Institute;Research Personnel;Resource Sharing;Sampling;Screening for cancer;Services;single cell analysis;Small RNA;square foot;Statistical Data Interpretation;Strategic Planning;Students;Technology;tool;Training;Training and Education;transcriptome sequencing;tumor heterogeneity;Tumor Subtype;Tumor Suppressor Proteins;Variant;Work


PI_NAMEs: LECHLEITER, JAMES D (contact)

PROJECT_TERMS: Animals;anti-cancer research;Applications Grants;Award;cancer cell;Cancer Center;cancer imaging;cell fixing;Collection;Consult;Consultations;Cultured Cells;Custom;Dental Schools;design;digital;digital imaging;Doctor of Philosophy;Equipment;Event;experience;Experimental Designs;Feasibility Studies;Fluorescence;fluorescence lifetime imaging;Funding;Goals;Health;high resolution imaging;Human Resources;Image;Image Analysis;imaging capabilities;imaging system;Imaging Techniques;Imaging technology;improved;in situ imaging;In Vitro;in vivo;Individual;instrument;instrumentation;Isoflurane;Laboratories;Lasers;Letters;Light;live cell imaging;Location;Measures;member;Methodology;Microscope;Microscopic;microscopic imaging;Microscopy;Mission;Modernization;multiphoton microscopy;operation;optical imaging;Optics;Peer Review;Physiology;Preparation;Recommendation;reconstruction;Research;research facility;Research Personnel;Reservations;Resolution;Resource Sharing;Rodent;Sampling;Scanning;Services;Side;single molecule;Site;South Texas;Specimen;spectrograph;square foot;Stress;superresolution imaging;superresolution microscopy;System;temporal measurement;Texas;Time;Tissues;Training;ultra high resolution;Universities;Ventilator;whole animal imaging


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Disability Research;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE The proposed pipeline program—Summer Health Academic Research Experience in Communication Sciences and Disorders (SHARE-CSD)—is a 6-week summer research experience for undergraduate students from backgrounds typically underrepresented in STEM and health fields. The proposal includes both an intensive, mentored summer research experience along with academic and career development training, and it also includes long-term continued peer and faculty mentoring, as research indicates that having a supportive network is an important component of success for students from underrepresented groups.

PI_NAMEs: ARUNACHALAM, SUDHA ;LEVI, SUSANNAH  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Academia;Academic achievement;academic preparation;Academic skills;Address;Area;Award;career;career development;career networking;career preparation;Censuses;Clinical;clinical practice;cohort;Collaborations;combat;Communication;Data;demographics;Development;disability;Disability status;Disease;Disparity;Diverse Workforce;economic disparity;Economics;education research;Educational Curriculum;Educational workshop;ethnic minority;Ethnic Origin;Evaluation;experience;Exposure to;Faculty;faculty mentor;Financial Hardship;follow-up;Foundations;Funding;Graduate Education;graduate school;hands on research;Health;health disparity;higher education;Individual;journal article;Journals;Learning;member;mentoring community;Mentors;Methodology;Minority;Minority Groups;minority student;Multicultural Education;Participant;peer;peer coaching;Personal Growth;Play;Population;Positioning Attribute;Program Evaluation;programs;Race;racial identity;racial minority;Readiness;Research;Research Personnel;Research Project Grants;Role;Scholarship;Science;Self-reflection;skills;social;Social Network;Students;success;summer program;summer research;Surveys;symposium;Training;undergraduate research experience;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Work

PROJECT_TITLE: SHARE CSD: An undergraduate summer experience to increase diversity in the CSD research pipeline


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Orphan Drug;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: VADLAMUDI, RATNA K (contact)

PROJECT_TERMS: Address;Adipose tissue;Affect;Agonist;anti-cancer research;Antibody Therapy;Area;Basic Science;Bioinformatics;Biology;Biometry;bone cell;Breast;Breast Cancer Cell;cancer cell;Cancer Center;Cancer Control;Cancer Etiology;cancer prevention;cancer therapy;Catchment Area;Cell Communication;Cells;Chemicals;chromatin modification;Chromosomes;Clinic;Clinical;clinical translation;Clinical Trials;Collaborations;Communication;Defense Mechanisms;Development;Developmental Therapeutics Program;Diagnosis;Direct Costs;Disease Progression;DNA crosslink;DNA Damage;DNA Repair;Doctor of Philosophy;driving force;drug discovery;Endocrine;Endometrial;Environment;Epigenetic Process;equol;ERCC1 gene;Estrogen Receptor 2;Estrogens;EWS-FLI1 fusion protein;Faculty Recruitment;Fanconi's Anemia;Flow Cytometry;Funding;Future;Genes;Genetic;Genome;Genomics;Glioblastoma;Goals;Grant;Health;Hispanic Populations;hormonal signals;hormone therapy;Hormones;host neoplasm interaction;Imipramine;Immune;Immune signaling;Immunity;Inflammatory;inhibitor;insight;Institution;Invaded;Investigational Therapies;Journals;Laboratories;Lead;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;medical schools;member;Metabolism;Metastatic breast cancer;Modeling;Molecular;Nature;NCI-Designated Cancer Center;Neoplasm Metastasis;neoplastic cell;Neoplastic Processes;new therapeutic target;next generation sequencing;novel;Obesity;Obesity associated cancer;Oncogenic;Paper;paracrine;Paracrine Communication;Pathogenicity;Pathway interactions;Peer Review;Pheochromocytoma;Population Sciences;preclinical study;Prevention program;Production;programs;Proteins;Publications;Publishing;Reader;recruit;Regimen;Regulation;Regulatory T-Lymphocyte;repaired;Reporting;Research;Research Personnel;Resistance;Resources;response;Role;Scientific Advances and Accomplishments;Seminal;small molecule inhibitor;Somatic Mutation;South Texas;steroid hormone;Strategic Planning;Stromal Cells;structural biology;success;Technical Expertise;Testing;Texas;therapy development;therapy resistant;tool;Translating;translational potential;Translational Research;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppression;Universities;Work


ORG_DEPT: PATHOLOGY

ORG_STATE: MN

PHR: RELEVANCE NARRATIVE Neurotoxicity is the major adverse side effect limiting the efficacy of CAR T-cells, a type of cancer immunotherapy. Neurotoxicity cannot be prevented or treated adequately because our understanding of how it occurs is poor. This project employs a unique mouse model of CAR T-cell-induced neurotoxicity to test hypotheses about its etiology and strategies to prevent or blunt its effects.

PI_NAMEs: PENNELL, CHRISTOPHER A (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adverse effects;Adverse event;Affect;Area;Astrocytosis;Autologous;B lymphoid malignancy;B-Cell Leukemia;B-Cell Neoplasm;B-Lymphocytes;Basic Science;Behavior;Blood brain barrier dysfunction;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier function;Brain;brain parenchyma;C57BL/6 Mouse;cancer immunotherapy;cancer type;CAR T cell therapy;CD19 Antigens;CD19 gene;Cell surface;Cells;Central Nervous System;cerebral mural cells;Cerebrovascular system;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;cost;cytokine;Differentiation Antigens;Disorientation;Elements;engineered T cells;Engineering;Etiology;experience;experimental study;Extravasation;Functional disorder;Gene Expression;Genetic;Genetic Engineering;Gliosis;Hospitalization;Human;humanized mouse;Immunocompetent;Immunologics;Immunotherapy;improved;In complete remission;In Situ;Infiltration;Inflammatory;Infusion procedures;Learning;leukemia/lymphoma;Leukocytes;Liquid substance;Methods;Microglia;Modeling;Morbidity - disease rate;mouse model;Mus;Myeloid Cells;neoplastic cell;neuroinflammation;Neurologic;neuropathology;neurotoxicity;novel;Patients;Peripheral;pharmacologic;prevent;programs;protein expression;Refractory;Reporting;retroviral transduction;Sampling;side effect;Specificity;Symptoms;T-Lymphocyte;Testing;Toxic effect;Transgenes;Transgenic Mice;Translational Research;tumor;Tumor Burden

PROJECT_TITLE: Unraveling the Pathophysiology of Neurotoxicity Induced by CAR T-cells

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: BRENNER, ANDREW JACOB (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Agonist;anti-depressive agents;aptamer;Area;Basic Science;Bioinformatics;Biology;Biometry;Bladder Urothelium;Breast;Cancer Center;cancer clinical trial;Cancer Etiology;Cancer Survivor;cancer therapy;Catchment Area;Child;Childhood Malignant Brain Tumor;Clinical;clinical development;Clinical Research;Clinical Trials;Collaborations;Conduct Clinical Trials;Dental;Development;Developmental Therapeutics Program;Doctor of Medicine;Doctor of Philosophy;Drug Combinations;drug development;drug discovery;drug repurposing;early phase clinical trial;Estrogen Receptor 2;FDA approved;Funding;genome-wide;Glioblastoma;Goals;Grant;Growth;Health;high throughput screening;Hypoxia;Immune response;Immunologic Markers;Immunooncology;immunoregulation;Immunotherapy;Impaired cognition;improved;Institution;Intervention;Intervention Trial;Investigational Drugs;Investigational Therapies;Journals;Lead;lead candidate;Libraries;malignant mouth neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Medical;Medulloblastoma;member;MicroRNAs;Modeling;Mus;Mutation;Natural Products;NCI-Designated Cancer Center;neuro-oncology;new therapeutic target;non-muscle invasive bladder cancer;novel;novel therapeutics;Obesity associated cancer;Patients;Peer Review;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Physicians;Physiological;Play;Preclinical Testing;Prediction of Response to Therapy;Prodrugs;programs;Prostate;Publications;Reporting;Research;Resource Sharing;RNA;RNA methylation;RNA-Binding Proteins;Role;safety testing;Schools;Scientist;Seminal;Signal Pathway;Sirolimus;small hairpin RNA;small molecule;Strategic Planning;structural biology;T-Lymphocyte;targeted treatment;Testing;Texas;Therapeutic;Therapeutic Agents;therapeutic RNA;therapeutic target;therapy resistant;Tissues;translational pipeline;translational potential;Translational Research;translational scientist;triple-negative invasive breast carcinoma;tumor;tumor immunology;Universities;Untranslated RNA;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative: The prevalence of heart failure continues to rise, and for approximately half of all heart failure cases there are no approved therapies proven to modify the course of disease. This research will determine whether novel small molecule or genetic therapies that target a modification of the microtubule cytoskeleton can improve both the systolic and diastolic function of the heart in the setting of heart failure.

PI_NAMEs: PROSSER, BENJAMIN LEARS (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Affinity;Age;Animal Model;Animals;aorta constriction;Binding;Biotechnology;Calcium;Cardiac;Cardiac Myocytes;Cardiology;Cardiomyopathies;Cells;Circulation;Clinical;clinical translation;Clinical Trials;cohort;Complement;Contracts;Cytoskeleton;Disease;Drug Kinetics;EFRAC;Enzyme Stability;Enzymes;Equilibrium;Euthanasia;Evaluation;Exhibits;experimental study;Family Felidae;Felis catus;Functional disorder;Future;Gender;gene therapy;Genetic;genetic approach;Goals;Heart;heart cell;Heart failure;heart failure with reduced ejection fraction;heart function;Heart Hypertrophy;Human;Hypertrophic Cardiomyopathy;Impairment;improved;in vivo;Industry;inhibitor;insight;Mechanics;Microtubules;Modality;Modeling;Modification;mortality;Motion;mouse model;Mus;Muscle Cells;mutant;Myocardial;Myocardial tissue;Myocardium;new therapeutic target;Noise;novel;novel therapeutics;Organ Donations;overexpression;Patients;pharmacologic;Phenotype;Pilot Projects;Population;Post-Translational Protein Processing;preservation;pressure;Prevalence;programs;Proliferating;Recording of previous events;Relaxation;Research;Rodent;Science;Scientist;small molecule;small molecule inhibitor;Specialist;Speed;Surgical Models;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;Work

PROJECT_TITLE: Detyrosinated microtubules in cardiomyocyte mechanics

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Childhood Obesity;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Lung;Lung Cancer;Nutrition;Obesity;Pediatric;Physical Activity;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Tobacco;Tobacco Smoke and Health;Urologic Diseases;Women's Health Research

PI_NAMEs: TOMLINSON, GAIL ELIZABETH (contact)

PROJECT_TERMS: Achievement;Address;Adolescent;Adult;Age;Assessment tool;Behavior Therapy;Behavioral;Bioinformatics;Biological Markers;biomarker signature;Biometry;Biopsy;Breast Cancer Patient;breast cancer survival;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer prevention;Cancer Prognosis;cancer risk;cancer subtypes;Cancer Survivorship;Catchment Area;Cells;Chemoprevention;Chemopreventive Agent;Child;Clinical;Clinical Research;Collaborations;Communities;community engagement;Community Outreach;Core Facility;cost effective;County;cytokine;Detection;detection method;Development;Developmental Therapeutics Program;Diet;Dietary Intervention;Direct Costs;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;early onset;Educational Models;Endometrial Carcinoma;epigenetic marker;Epigenetic Process;evidence base;Evidence based intervention;Exercise;exercise intervention;Exposure to;Faculty;Faculty Recruitment;Formulation;Funding;Genetic;genetic epidemiology;Genetic Markers;genetic risk assessment;geographic barrier;Geographic Locations;Goals;Grant;HCV and Aflatoxin;Health;Health Services Accessibility;Hepatitis C;Hispanic;Hispanic Populations;Human Papilloma Virus Vaccine;Improve Access;improved;improved outcome;Incidence;Individual;Infection;Inflammatory;Institution;Intervention;Intervention Studies;Intervention Trial;Investigational Therapies;Journals;Leadership;Legal patent;Life Style Modification;liquid biopsy;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Methods;Mexican;Molecular;multidisciplinary;Natural Products;NCI-Designated Cancer Center;novel;Nutritional;Obesity;Outcome;Patients;Peer Review;Physical activity;Population;Population Sciences;Populations at Risk;predictive marker;predictive signature;predictive tools;prevent;Prevention;Prevention program;Prevention strategy;Primary carcinoma of the liver cells;Primary Prevention;programs;prostate cancer risk;Publications;quality of life for cancer survivors;recruit;Recurrence;Reporting;Research;Research Personnel;research study;Resources;Risk;Risk Factors;Risk Marker;Rural;Schools;screening;Screening for cancer;Secondary Prevention;Seminal;Services;Sirolimus;skills;smoking cessation;South Texas;survivorship;tertiary prevention;Testing;Texas;Text Messaging;Therapeutic;Tobacco Use Cessation;Translating;Translations;tumor progression;underserved minority;Underserved Population;Uninsured;Universities;Update;Woman;Work;working group;Yoga;young adult


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Mental Illness;Pain Research;Pediatric;Prescription Drug Misuse;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Millions of our youth suffer from pain and psychological symptoms that, when poorly managed, put youth at risk for poor health outcomes. Many teens try to self-manage symptoms by using and misusing prescribed drugs or other substances on their own without supervision. Our research will help explain how complex symptoms and other influences (family and environment) contribute to risky self-treatment behaviors and will evaluate the potential impact of interventions meant to protect against risky behavior.

PI_NAMEs: VOEPEL-LEWIS, TERRI DIANE (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: 10 year old;13 year old;Address;Adolescence;Adolescent;Adolescent Development;Adult;Age;Age Factors;Alcohols;Anti-Anxiety Agents;Anxiety;associated symptom;Behavior;Behavior Therapy;Behavioral;Brain;Cannabis;Characteristics;Child;Child Health;Childhood;Chronic;Cognition;cognitive development;Cognitive Therapy;comorbidity;Complex;cost;critical developmental period;Data;Diagnosis;Drowsiness;Drug Exposure;Drug Prescriptions;early adolescence;Early Intervention;early onset;Education;Enrollment;Environment;Environmental Risk Factor;Epidemiology;Evolution;Exhibits;Family;Family health status;Fatigue;Future;Gender Identity;Goals;grandparent;Health;health care availability;hypnotic;improved;in silico;Individual;innovation;intergenerational;Intervention;Knowledge;longitudinal analysis;Medical;Mental Depression;Mental Health;misuse of prescription only drugs;Modeling;models and simulation;Motivation;multidisciplinary;Opioid;Pain;Pain management;pain model;pain symptom;Parents;Pathway interactions;Pattern;peer;Perception;Persistent pain;persistent symptom;person centered;Pharmaceutical Preparations;Pharmacological Treatment;poor health outcome;Post-Traumatic Stress Disorders;preadolescence;predictive signature;prescription opioid misuse;prevent;preventive intervention;psychologic;psychological symptom;Puberty;Recurrent pain;reduce symptoms;Reporting;Research;resilience;response;Risk;Risk Behaviors;Risk Factors;risk perception;risk prediction model;Risk Reduction;Self Management;Self Medication;sex;Sleep Disorders;social;substance misuse;substance use;Substance Use Disorder;Supervision;symptom cluster;symptom self management;Symptoms;Teenagers;Testing;Time;Tobacco;Trauma;trauma exposure;Youth

PROJECT_TITLE: The Symptom-Associated Pathway to Substance Use and Misuse during Adolescence

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Breast Cancer;Burden of Illness;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health;Tobacco;Women's Health Research

PI_NAMEs: RAMIREZ, AMELIE G (contact)

PROJECT_TERMS: Address;Adult;adult obesity;Affect;anti-cancer research;Area;Area Health Education Centers;bilingualism;Bioinformatics Shared Resource;Biometry;Cancer Burden;cancer care;Cancer Center;Cancer Intervention;Catchment Area;Colorectal Cancer;Communities;community advisory board;community engagement;Community Health Aides;Community Health Education;Community Outreach;Comprehensive Cancer Center;Continuity of Patient Care;County;Doctor of Public Health;Education;Ensure;Ethnic Population;Funding;Goals;Health;health disparity;Health Policy;Health Services Accessibility;High Prevalence;high school degree;Hispanic Populations;Home;Incidence;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mammography;member;metropolitan;Mexico;Mission;modifiable risk;Monitor;mortality;NCI Center for Cancer Research;Obesity;patient oriented;Persons;Population;Population Sciences;Poverty;Prevention program;programs;racial population;Research;Research Support;Risk Factors;screening;Smoker;South Texas;Stretching;Testing;Texas;Tobacco;Tobacco smoking behavior;Translating;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_DEPT: EMERGENCY MEDICINE

PHR: Narrative Cardiovascular disease is the leading cause of morbidity in the United States and many Americans struggle with modifying health behaviors which could improve their overall health and life-expectancy. This K24 proposal focuses on using new and emerging digital data sources and methodologies (e.g. big data analytics, machine learning, natural language processing) to better phenotype health behaviors which can be modified to improve cardiovascular health. Through this K24, Dr. Merchant will develop and implement 1) a successful and high-impact research program focused on advancing CV health and digital data science and 2) a successful and enduring mentorship program focused on training and supporting the next generation of patient-oriented researchers who can advance this field to improve the CV health of individuals and communities.

PI_NAMEs: MERCHANT, RAINA  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;Affect;Age;American;Area;Attitude;Behavior;Big Data Methods;Blood Pressure;burden of illness;Caliber;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career;career development;Cellular Phone;Cholesterol;Clinical;clinical application;clinical practice;Clinical Trials;Communication;Communities;Competence;Complement;Complex;Computer Models;computer science;computer scientist;Coupled;Data;Data Science;Data Set;Data Sources;data streams;demographics;Development;Devices;Diet;digital;digital applications;digital communication;digital data;digital health;digital intervention;digital media;digital phenotyping;digital platform;Disease;disorder risk;Engineering;Environment;Ethics;Event;experience;Faculty;Foundations;frontier;Funding;Future;Gender;Geography;Glucose;Grant;Growth;Health;Health behavior;health data;Human;human capital;implementation barriers;improved;improved outcome;Income;Individual;insight;Institution;Internet;Intervention;Investigation;Knowledge;Leadership;Life Expectancy;Link;Machine Learning;Measures;Medicine;Mentors;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Mining;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Natural Language Processing;next generation;novel;Observational Study;Outcome;Patient Education;patient oriented;patient oriented research;Patient Preferences;Patients;Pennsylvania;Phenotype;phenotypic data;Physical activity;Population;precision medicine;Privacy;Process;programs;Race;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Support;Resources;response;risk prediction;Safety;Scientist;Security;sensor;Smoking;social media;Source;Structure;System;Time;tool;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Minority;United States;United States National Institutes of Health;Universities;uptake;Weight;Work

PROJECT_TITLE: Mentoring and Patient Oriented Research in Cardiovascular Health and Digital Data Science

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


PI_NAMEs: MESA, RUBEN A. (contact)

PROJECT_TERMS: Area;Award;base;Basic Science;biobank;Cancer Center;Cancer Center Support Grant;cancer research center director;Catchment Area;Clinical;Clinical Research;community engagement;Community Outreach;Consultations;Development;Doctor of Medicine;Faculty;Faculty Recruitment;faculty support;Funding;Funding Category;Grant;Health;Individual;Institution;Investments;Leadership;member;NCI Center for Cancer Research;Pilot Projects;programs;recruit;Reporting;Research;Resource Development;Resource Sharing;Science;Source;Strategic Planning;survivorship


PROJECT_TERMS: Advisory Committees;anti-cancer research;Area;authority;Award;base;Basic Science;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;career;Catchment Area;Clinical;clinical infrastructure;Clinical Research;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Consensus;Core Grant;Counseling;Development;Doctor of Medicine;Doctor of Philosophy;Doctor of Public Health;Education;educational atmosphere;Elements;Ensure;Evaluation;Faculty Recruitment;Feedback;Fostering;Funding;Goals;Grant;Growth;Health;higher education;Hispanic Populations;improved;Individual;Institution;Leadership;Malignant Neoplasms;member;Mission;NCI Center for Cancer Research;outreach;Process;Productivity;programs;Recommendation;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resource Allocation;Resource Sharing;Resources;Robin bird;Role;Science;Services;Source;Strategic Planning;Structure;Texas;Universities;Update;Virginia;Vision;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The overarching goal of this project is to provide an explanatory analysis of coding by neural populations in midbrain and forebrain regions underlying sound localization functions. [This goal will be addressed by population recordings within and across midbrain and forebrain areas of the sound localization pathway of both awake and anesthetized barn owls supporting spatial discriminability and stimulus selection, and testing sound localizing behaviors.] The mechanistic hypotheses mediating these functions that will be specifically tested are a built-in representation of sensory statistics optimizing spatial discriminability and co-modulation of temporal spiking patterns by sound-identity features as well as brain oscillations underlying stimulus selection across space. Finally, simultaneous population recordings across brain regions involved in sound localization will provide a wide-ranging perspective of how populations interact across brain regions involved in sound localization. This research will contribute to explain population coding underlying implementation and optimization of relevant sound localization functions and elucidate the routing of activity along the central auditory system.

PI_NAMEs: PENA, JOSE L (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Achievement;Acoustics;Address;Adolescent;Anesthesia procedures;Animals;Area;Auditory;Auditory Perception;auditory processing;Auditory system;Automobile Driving;awake;Barn Owls;base;Behavior;Behavioral;Behavioral Assay;behavioral study;Binaural;Biological Assay;Birds;Brain;Brain region;Cells;Code;Cues;Data;Dependence;design;detection platform;deviant;early experience;Frequencies;Goals;Head;Hearing problem;Human;improved;in vivo;indexing;Life;Location;Mammals;Maps;Mediating;Midbrain structure;multi-electrode arrays;neural;Neurons;novel strategies;Pathway interactions;Pattern;Population;Property;Prosencephalon;Reporting;Research;response;Role;Route;Scheme;segregation;Sensory;Signal Transduction;sound;Sound Localization;Source;Space Perception;statistics;Stimulus;Strigiformes;Structure;Testing;Time;trend;Work

PROJECT_TITLE: Coding of auditory space in the avian brain


NIH_SPENDING_CATS: Cancer;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: KAKLAMANI, VIRGINIA GEORGIA (contact)

PROJECT_TERMS: Amendment;authority;Cancer Center;Catchment Area;Charge;Child;Clinical Cancer Center;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Conduct Clinical Trials;Data;data integrity;data management;data quality;Decentralization;demographics;Development;Disease;Doctor of Medicine;Doctor of Philosophy;Enrollment;Ensure;Goals;Guidelines;Health;Hispanic;Industry;Infrastructure;Institution;Institutional Review Boards;Intervention;Investigational Therapies;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;member;men;Minority;Monitor;NCI Center for Cancer Research;Newly Diagnosed;Occupations;operation;participant safety;patient safety;Patients;Pediatric Oncology;Pediatric Oncology Group;Peer Review;Policies;Procedures;Protocol Compliance;Protocols documentation;quality assurance;Quality Control;Recommendation;Regulation;Reporting;Research;Research Personnel;research study;Research Support;Safety;safety study;Site;System;Time;Training;Training Activity;Training and Education;Virginia;Woman;Work


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: HA, CHUL SOO (contact)

PROJECT_TERMS: Area;authority;Budgets;Cancer Center;Charge;Clinical;Clinical Protocols;Clinical Research;Clinical Research Protocols;Clinical Trials;clinically relevant;Collaborations;Committee Membership;Data;Discipline of Nursing;Disease;Doctor of Medicine;Doctor of Philosophy;dosage;Drug Kinetics;Ensure;Evaluation;expectation;Focus Groups;Health;innovation;Institutional Review Boards;interest;Logistics;Malignant Neoplasms;Monitor;operation;Peer Review;Pharmaceutical Preparations;Pharmacy facility;Physicians;Population;pre-clinical;Process;Protocols documentation;Recommendation;Research;Resources;Review Committee;Risk Assessment;Safety;Site;Structure;System;Work


ORG_DEPT: GENETICS

PHR: Public Health Relevance/Narrative Emerging evidence indicates that epigenetic mechanisms are centrally linked to the development of the mammalian central nervous system and go awry in neurological disorders. Here, we unravel the functional link between long-range 3D genome folding patterns and synaptic plasticity during the encoding of long-term memory in the mammalian brain. Because many key neurological disorders are thought to be diseases of the synapse, successful completion of this work will provide a foundation for future studies unraveling the role for misfolded genome topology on the onset and progression of neurodevelopmental and neurodegenerative disorders.

PI_NAMEs: PHILLIPS-CREMINS, JENNIFER ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Brain;Cell Reprogramming;cell type;Central Nervous System;Chromatin;connectome;CRISPR screen;Data Set;Defect;Development;Disease;Engineering;Epigenetic Process;Exhibits;Foundations;Fragile X Syndrome;Functional disorder;Future;Gene Expression;Genetic;Genetic Transcription;Genome;genome-wide;Goals;Imaging technology;In Vitro;in vivo;in vivo Model;Individual;insight;Knowledge;Length;Link;long term memory;Maps;Memory;memory consolidation;memory encoding;Modification;Molecular;Nervous System Disorder;neural;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Neurosciences;Pathologic;Pattern;Phenotype;Physiological;Proteins;public health relevance;RNA;Role;single cell genomics;Somatic Cell;Structure-Activity Relationship;Synapses;Synaptic plasticity;Technology;transcription factor;Work;Writing

PROJECT_TITLE: From 3D genomes to neural connectomes: Higher-order chromatin mechanisms encoding long-term memory


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE The goal of the MIT Roybal Center is to develop and evaluate translational behavioral interventions to improve health and healthcare delivery for older people. The Management and Administrative Core and the Pilot Core will support the development of promising interventions and evaluations, provide support to pilot projects selected through a peer review process, and leverage lessons learned to create publicly-available resources.

PI_NAMEs: FINKELSTEIN, AMY N. (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute pain management;Address;Advance Care Planning;advanced directive;Affect;Aging;aging population;behavior test;Behavior Therapy;Behavioral Model;Behavioral trial;care coordination;Caring;Center for Translational Science Activities;Collaborations;community setting;Complex;cost;Data;Decision Making;Development;Dose;end of life;end of life care;Epidemic;Evaluation;experience;Foundations;Funding;Goals;Health;health care delivery;Healthcare;Healthcare Systems;Height;improved;Individual;innovation;International;Intervention;Leadership;Massachusetts;Medical;middle age;Mission;Modeling;North America;novel;older adult;Older Population;opiate tolerance;Opioid;opioid epidemic;Outcome;Overdose;Pain management;Pathway interactions;Patient Preferences;patient tolerability;Patients;Peer Review;Personal Satisfaction;Persons;Pilot Projects;pilot test;Policies;Population;Poverty;Principal Investigator;Process;professor;Program Development;public health emergency;Randomized;Randomized, Controlled Trials;Research;Research Project Grants;Resources;Risk;Role;Specialist;Technology;Testing;therapy development;Time;treatment as usual;United States;Universities;vehicular accident

PROJECT_TITLE: MIT Roybal Center for Translational Research to Improve Healthcare for the Aging


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: academic review;Advisory Committees;Aging;aging population;Agreement;Area;Award;Awareness;Behavior Therapy;Center for Translational Science Activities;Collaborations;Communication;Contracts;cost;Cost Analysis;Data;Databases;design;Development;Ensure;Evaluation;Feedback;Funding;Goals;Growth;Health;Health Policy;Healthcare;improved;Infrastructure;innovation;interest;Knowledge;Leadership;Mediation;meetings;member;Monitor;National Institute on Aging;North America;Office of Administrative Management;older adult;Outcome;outreach;Persons;Pilot Projects;Policies;Policy Maker;Poverty;Process;Progress Reports;prospective;Publications;Randomized;Reporting;Request for Proposals;Research;Research Personnel;Research Project Grants;Resources;therapy development;Translating;Travel;web site;Work

PROJECT_TITLE: Management and Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Advisory Committees;Aging;aging population;Area;Award;Behavior Therapy;behavioral economics;Behavioral Mechanisms;Behavioral Sciences;Behavioral trial;Center for Translational Science Activities;Collaborations;Complement;Conflict of Interest;cost;Data;Data Collection;design;Development;Discipline;Economics;Evaluation;Event;evidence base;experimental study;Feedback;Funding;Government Agencies;Grant;Health;health care delivery;health plan;Healthcare;Hospitals;improved;improved outcome;Infrastructure;innovation;insight;interest;Intervention;Mentorship;middle age;North America;older adult;Older Population;Outcome;peer;Peer Review;Pilot Projects;Policies;Policy Maker;Poverty;Process;professor;Program Development;Publications;Randomized;Randomized, Controlled Trials;Request for Proposals;Research;Research Assistant;Research Design;Research Personnel;Research Project Grants;Resources;service providers;Suggestion;symposium;Testing;therapy design;Training;Universities;Work

PROJECT_TITLE: Pilot Core


NIH_SPENDING_CATS: Cancer

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: The Nomura Research Group is focused on reimagining druggability by advancing and applying chemoproteomic platforms to tackle the undruggable proteome, towards developing next- generation therapies and therapeutic modalities for cancer.

PI_NAMEs: NOMURA, DANIEL  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Antineoplastic Agents;Binding;chemoproteomics;Development;drug discovery;innovative technologies;Ligands;Malignant Neoplasms;Modality;next generation;novel therapeutics;pharmacologic;Proteins;Proteome;Research;targeted treatment;Therapeutic

PROJECT_TITLE: Tackling Undruggable Cancer Targets using Chemoproteomic Platforms


NIH_SPENDING_CATS: Diabetes;Nutrition

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Obesity and Type 2 diabetes have reached epidemic proportions, and most diabetics die from cardiovascular disease. We will investigate the molecular mechanisms involved in regulation of lipoprotein metabolism by insulin, with a focus on the regulation of LDL receptor trafficking in liver cells.

PI_NAMEs: SALTIEL, ALAN R. (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acceleration;Actins;Acute;Adipocytes;Attention;Binding;Biology;blood glucose regulation;Cardiovascular Diseases;Catalytic Domain;Cell membrane;Cells;Cholesterol;Cholesterol Homeostasis;Complex;CRISPR/Cas technology;Cytoskeleton;Data;diabetic;Diabetic mouse;Disease;Dyslipidemias;Elements;Endocytosis;Epidemic;Event;Exocytosis;Fasting;feeding;gain of function;gene product;Genes;glucose uptake;GTP-Binding Proteins;GTPase TC10;GTPase-Activating Proteins;Health;Hepatic;Hepatocyte;High Fat Diet;Hormonal;hormone regulation;In Vitro;in vivo;insight;Insulin;Insulin Receptor;insulin regulation;Insulin Resistance;Investigation;Knock-out;Knockout Mice;Ligand Binding;Ligands;lipid metabolism;Lipoproteins;Liver;loss of function;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;LoxP-flanked allele;Mediating;Membrane;Membrane Fusion;Metabolism;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mus;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Nutritional status;Obesity;Pathway interactions;Phosphorylation;Physiological;Play;polarized cell;Process;Proteins;RALA Protein;receptor;receptor internalization;receptor recycling;recruit;Recycling;Regulation;Role;Signal Pathway;Signal Transduction;Site;Specificity;Structure;superresolution microscopy;Testing;Therapeutic Intervention;trafficking;Transcriptional Regulation;uptake;Vesicle;whole genome

PROJECT_TITLE: Hormonal regulation of LDL receptor trafficking

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Anorexia;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Eating Disorders;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Nutrition;Precision Medicine;Serious Mental Illness

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Anorexia nervosa (AN) has the highest mortality rate of any psychiatric illness, yet we have a poor understanding of the biological causes of this disorder. In this proposal we examine the basic question of whether individuals with AN have poorer “gut sensations” which enable them to fast and lose weight despite severe medical consequences. In this project, we use a novel probe, which may eventually be useful as a marker for diagnosis, prognosis, and treatment success in AN.

PI_NAMEs: KHALSA, SAHIB  (contact);PAULUS, MARTIN P.

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Affective;Age;Anorexia Nervosa;Anxiety;anxious;Arbitration;Arousal;Attention;Attenuated;attenuation;Automobile Driving;Awareness;Behavior;Binge eating disorder;Biological;Biological Assay;Body mass index;Body Weight decreased;Brain;brain abnormalities;Bulimia;Calibration;capsule;Case/Control Studies;Characteristics;classifier algorithm;Clinical;clinically relevant;Cognitive;Computer Models;cost;Cues;Data;Death Rate;Desire for food;Development;Diagnosis;Diagnostic;diagnostic biomarker;Disease;Disease remission;Eating;Eating Behavior;Eating Disorders;effective therapy;Electroencephalography;Esthesia;Exhibits;expectation;Female;Food;food restriction;Functional disorder;Future;gastrointestinal;gastrointestinal system;Goals;Hunger;improved;Individual;Individual Differences;individual patient;Ingestion;Inpatients;insight;Interoception;Intervention;Knowledge;Lead;Learning;Machine Learning;machine learning method;Measurement;Measures;Medical;Medicine;Mental disorders;mind body interaction;minimally invasive;Modeling;Motivation;Nervous System;neural;neural circuit;Neurobiology;neurophysiology;new technology;novel;Outcome;Pattern;Physiological;Physiology;predict clinical outcome;prediction algorithm;predictive marker;Process;Prognosis;Prognostic Marker;Psychiatry;Recovery;Relapse;relapse risk;Research;response;risk prediction;Role;Sampling;Sensory;Severities;Severity of illness;sex;Signal Transduction;Stomach;success;Symptoms;Testing;Time;tool;Training;vibration;Weight

PROJECT_TITLE: A neurocomputational assay of gastrointestinal interoception in anorexia nervosa

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Sexually Transmitted Infections

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative TDP-43 protein is dysfunctional in various neurodegenerative diseases. Recent findings suggest that TDP-43 dysfunction alters innate antiviral responses in the brain, which may contribute to Alzheimer’s disease (AD) and other dementias. The exact causal relationship between TDP-43 and antiviral pathways will be examined in order to uncover potential therapeutic targets for AD and related neurodegenerative diseases.

PI_NAMEs: JACKVONY, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: adeno-associated viral vector;Affect;Alternative Splicing;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Anti-viral Response;antimicrobial;Astrocytes;Binding;Brain;case control;cell type;Cells;Cytoplasm;Data;Dementia;differential expression;Disease;Disease Progression;DNA Transposable Elements;DNA-Binding Proteins;effective therapy;Exposure to;Frontotemporal Dementia;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Herpes Simplex Infections;Herpesvirus 1;Hippocampus;Human;Immune;Immune response;Impairment;In Vitro;in vivo;in vivo Model;Injections;interest;Interferons;knock-down;Laboratory Finding;Link;Molecular;Monitor;mouse model;Mus;mutant;Natural Immunity;Nerve Degeneration;neural;Neurodegenerative Disorders;Neuroimmune;Neurologic;Neurons;new therapeutic target;non-demented;novel;Nuclear;Onset of illness;Outcome;overexpression;pathogen;pathogenic virus;Pathogenicity;Pathologic;Pathology;Pathway interactions;pharmacologic;Physiological;Plaque Assay;Poly I-C;Predisposition;prevent;Process;protein TDP-43;Proteins;response;risk variant;RNA;RNA Binding;RNA Processing;RNA Recognition Motif;RNA Splicing;RNA Transport;RNA-Binding Proteins;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Techniques;Testing;therapeutic target;Transcriptional Regulation;transcriptome sequencing;Variant;Viral;Virus Diseases;Western Blotting

PROJECT_TITLE: Effects of TDP-43 Pathology on Innate Antiviral Mechanisms in Neurodegenerative Disease


NIH_SPENDING_CATS: Aging;Data Science;Social Determinants of Health

PHR: Project Narrative The goal of this R25 program is to increase the participation of underrepresented minority groups in the fields of Biostatistics and quantitative Public Health, with a collaborative focus on the diseases and processes of aging. The program includes an intensive six-week summer program for 12 students, with formal and informal instruction, mentored research, and extensive professional development activities, with a culminating symposium. For lasting impact, follow-up mentoring, continuing research and professional development will occur on a regular basis, both via webcast platforms and return, in-person visits.

PI_NAMEs: BETENSKY, REBECCA A. (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academia;Address;Advisory Committees;Aging;aging population;aging process;aging related;Alzheimer's disease model;Attention;Autopsy;Big Data;biomarker selection;Biometry;career;Career Choice;cohort;community building;Country;Data Analyses;Data Science;design;Development;Disease;Disparity;Diverse Workforce;Education;Education Projects;Epidemiology;epidemiology study;ethnic disparity;ethnic minority;experience;Faculty;faculty mentor;follow-up;Funding Opportunities;Goals;graduate school;graduate student;GRE Preparation;Health Personnel;improved;Individual;informal learning;Instruction;interest;Joints;Journals;Learning;lectures;Life;Machine Learning;Medicine;meetings;Mentors;Methods;Minority Groups;minority investigator;minority undergraduate;Oral;Outcome;Participant;Persons;Population;posters;programs;Public Health;racial disparity;racial minority;Research;Research Project Grants;response;responsible research conduct;Science;Series;Site Visit;social;Statistical Computing;student mentoring;Students;summer program;symposium;Talents;Time;Training;undergraduate education;undergraduate student;Underrepresented Minority;underrepresented minority student;Visit

PROJECT_TITLE: Pipelines into Quantitative Aging Research


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH NARRATIVE  Osteoporosis is a common bone disease, especially in elderly men and women, and it leads to thin bones that are more prone to fracture. We are studying the actions of important proteins in the bone cells that may be able to slow down bone loss while also rebuilding bone. Our long term goal is to develop new drugs that will make bones stronger so that we can prevent osteoporosis in men and women.

PI_NAMEs: BRUZZANITI, ANGELA  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Acceleration;Actins;Address;Adverse event;age related decline;Aging;Alzheimer's Disease;antagonist;Architecture;Arm Bones;Biological Markers;bone;bone cell;Bone Diseases;bone loss;bone mass;bone quality;Bone remodeling;bone strength;Bone Tissue;C57BL/6 Mouse;Cardiovascular Diseases;Categories;cathepsin K;Chemicals;Clinical;clinical effect;clinical translation;Clinical Trials;clinically relevant;Collagen;Data;Deposition;Deterioration;Dimerization;Dual-Energy X-Ray Absorptiometry;Effectiveness;Elderly man;Elderly woman;Enzyme-Linked Immunosorbent Assay;ESR1 gene;Estradiol;Estrogen Receptor 2;Estrogen Receptors;Exhibits;Female;Femur;Focal Adhesion Kinase 1;Focal Adhesions;Fracture;Functional disorder;Genetic;Genotype;Goals;Gonadal Steroid Hormones;Hindlimb Suspension;human female;improved;In Vitro;in vitro activity;in vivo;inhibitor;Investigation;kinase inhibitor;Knowledge;LoxP-flanked allele;male;mechanical properties;Mechanical Stimulation;men;Menopause;middle age;mineralization;Minerals;Modeling;multicatalytic endopeptidase complex;Mus;novel strategies;novel therapeutics;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;Osteoporosis prevention;Osteoporotic;Ovariectomy;Phenotype;preservation;prevent;Property;Protein Tyrosine Kinase;Proteins;Public Health;Raloxifene;Raman Spectrum Analysis;Reporting;Repression;response;Role;seal;Selective Estrogen Receptor Modulators;Serum;sex;Sex Differences;Signal Transduction;skeletal;substantia spongiosa;Testing;Thick;Thinness;Tissues;translational impact;translational potential;Ubiquitin;ubiquitin mediated proteasome degradation;Woman

PROJECT_TITLE: Uncovering the dual anabolic and anti-catabolic effects of Pyk2 inhibition on bone mass

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Diabetes;Infectious Diseases;Networking and Information Technology R&D (NITRD);Nutrition;Regenerative Medicine;Rehabilitation;Wound Healing and Care

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Telemetric Regenerative Bandage for Accelerating Wound Healing Narrative This project describes the development of a shape-conforming antioxidant dressing that upon exposure to body temperature transforms into a vasculoinductive, dermoconductive and dermoinductive scaffold that promotes new tissue formation in diabetic wounds. It also involves developing a wireless wound feedback system that involves tissue conforming temperature and pH microsensors to monitor potential bacterial infection and/or lack of healing to improve patient outcome.

PI_NAMEs: AMEER, GUILLERMO ANTONIO (contact);ROGERS, JOHN

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Acrylamides;Address;Adhesions;Amputation;angiogenesis;Animal Model;Animals;Antioxidants;Bacterial Infections;Bandage;Biocompatible Materials;biomaterial compatibility;Blood Circulation;blood perfusion;Body Temperature;Caring;Cells;Chronic;Citrates;Clinic;Clinical;clinically relevant;Complications of Diabetes Mellitus;Copper;db/db mouse;Dermal;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;Digit structure;Disease;effective therapy;electronic sensor;Endothelial Cells;Engineering;Exposure to;Family suidae;Feedback;Fibroblasts;flexibility;Free Radicals;Gel;Goals;healing;Health;health care delivery;health care disparity;Healthcare;High Prevalence;Hospitals;Human;human disease;Immobilization;Impaired healing;Impaired wound healing;Impairment;Implant;improved;In Vitro;Incidence;Infection;Inflammation;innovation;keratinocyte;Laminin;Left;limb amputation;Limb structure;Location;Lower Extremity;macromolecule;Managed Care;Measures;Medical Device;Metabolic syndrome;Metals;microsensor;migration;Miniature Swine;Monitor;mouse model;nanoparticle;nanoparticle delivery;neovascularization;non-healing wounds;novel;Operative Surgical Procedures;outcome prediction;Oxidative Stress;Patient-Focused Outcomes;Patients;Peptides;Personal Satisfaction;Physicians;Polyethylene Glycols;Population;porcine model;Positioning Attribute;Prevalence;prevent;Process;Proliferating;Property;regenerative;Research;research clinical testing;Research Personnel;Safety;scaffold;sensor;Sepsis;Shapes;Skin;skin wound;Skin wound healing;Societies;Specific qualifier value;Sterile coverings;System;Telemetry;Temperature;Testing;therapy outcome;Thick;Time;tissue regeneration;Tissues;tool;Vascularization;wireless;wireless sensor;Work;wound;wound bed;wound care;wound closure;wound dressing;wound healing;Wound Infection

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Children orphaned in low-to-middle income countries experience high levels of food insecurity, economic adversity, and other social risk factors that impact their ability to engage in and benefit from mental health treatments. This project privileges the voice of Kenyan community members in co-creating strategies to address social risk factors that can be integrated into mental health treatment. Lay mental health counselors will learn to implement the strategies during treatment, and we will examine counselor perspectives on the strategies’ potential promise for addressing social risk factors and improving mental health care.

PI_NAMEs: JOHNSON, CLARA  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Address;Age;Attitude;Caring;Cessation of life;Child;Child Support;Client;Cognitive Therapy;Collaborations;Colonialism;Communities;community academic partnership;Community Health;Country;Decision Making;design;Development;Economics;Educational workshop;Effectiveness;Enrollment;Ensure;Europe;evidence base;experience;Face;Family;Feeling;Fees;fighting;food insecurity;Funding;Goals;Impairment;Improve Access;improved;improved outcome;Income;Individual;Intervention;Interview;Kenya;Learning;meetings;member;Mental Health;Mental Health Services;Methodology;National Institute of Mental Health;Orphan;Outcome;Persons;Policy Maker;Politics;Population;Poverty;Prevalence;Professional counselor;Provider;psychologic;Psychotherapy;Recommendation;Reporting;Research;Research Activity;Research Personnel;Resource-limited setting;Resources;response;Risk Factors;Schools;Self Efficacy;Self-control as a personality trait;social;social disparities;social exclusion;social stigma;Strategic Planning;Supervision;Support System;teacher;Terminology;Testing;Training;Trauma;Voice;volunteer;Work;Youth

PROJECT_TITLE: Attending to the “whole” child in mental health care: Utilizing a partnership approach to address social risk factors alongside an evidence-based psychotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)]


NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_DEPT: ORTHOPEDICS

PHR: Project Relevance  Osteoarthritis is the most common joint disease characterized by wear and tear of joint articular cartilage with no disease modifying drug available yet. This project will determine the novel role of epidermal growth factor receptor (EGFR) signaling in controlling the structure and function of knee articular cartilage during osteoarthritis progression. Information garnered from these studies will be important for advancing our current knowledge of cartilage biology and designing novel therapeutic strategies to treat osteoarthritis.

PI_NAMEs: QIN, LING  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Adult;Age Years;age-related disease;aggrecan;Aging;Animal Model;Animals;Arthralgia;arthropathies;articular cartilage;Attenuated;behavior test;Biology;Bovine Cartilage;Cartilage;cartilage degradation;Cells;Chondrocytes;clinically relevant;CREB1 gene;Data;Degenerative polyarthritis;design;Development;disability;Disease;DTR gene;Elderly;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;experimental study;gain of function;Gefitinib;Gene Modified;General Population;Genes;genetic approach;genetic manipulation;Growth Factor;Health;Histology;Homeostasis;Hypertrophy;improved;Joints;Knee;Knee Osteoarthritis;knock-down;Knowledge;Life;Ligands;loss of function;Lubrication;mechanical properties;Mechanics;Mediating;Modeling;Molecular;mouse model;Mus;nanoparticle;novel;novel therapeutic intervention;Operative Surgical Procedures;overexpression;Pain;Pathogenesis;Pathway interactions;Penetration;Personal Satisfaction;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Prevalence;prevent;Proteoglycan;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;repaired;Resolution;response;Role;Sclerosis;Series;Signal Pathway;Somatotropin;Structure;subchondral bone;Surface;Testing;Therapeutic Effect;Transforming Growth Factor alpha;Translating

PROJECT_TITLE: EGFR signaling in osteoarthritis and treatment

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health

ORG_CITY: BUEA

ORG_COUNTRY: CAMEROON

ORG_FIPS: CM

ORG_NAME: UNIVERSITY OF BUEA

PHR: PROJECT NARRATIVE Injuries and other surgically treated diseases comprise a significant burden of disease in Cameroon and other sub-Saharan African (SSA) countries with deep inequities that are particularly unmasked in acute care settings. D-SINE Africa Hub will focus on the intersection between injury and equity, leveraging data science to decrease the impact of trauma, surgical disease, and disparities on the population of Cameroon and SSA by promoting collaborative research, networking, and capacity building with an emphasis on equity.

PI_NAMEs: CHICHOM, ALAIN MEFIRE (contact);HUBBARD, ALAN E;JUILLARD, CATHERINE ;NGUEFACK , TSAGUE

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: acute care;Address;advanced analytics;Africa;Africa South of the Sahara;African;Algorithms;analytical method;Area;Big Data;burden of illness;California;Cameroon;Caring;Cellular Phone;clinical care;Collaborations;Communities;community building;community engagement;Congo;Country;Data;Data Analyses;Data Collection;data management;data quality;data reduction;Data Science;Data Set;Data Sources;Demographic and Health Surveys;Development;Disease;Disease Surveillance;disorder prevention;Disparity;Emergency Situation;epidemiology study;Equity;Evidence based intervention;follow-up;Funding;Goals;Grant;Health;health disparity;health equity;Health Services Accessibility;high risk;HIV;Hospital Referrals;Hospitals;Housing;implementation science;Improve Access;improved;Inequity;Infrastructure;Injury;injury burden;innovation;Institution;Joints;Los Angeles;low and middle-income countries;Machine Learning;mathematical sciences;meetings;member;Mentors;Methods;Mission;multidisciplinary;novel;Office of Administrative Management;Operative Surgical Procedures;Outcome;Participant;Pilot Projects;Policy Maker;Population;Prevention;prevention service;Prevention strategy;programs;Provider;Public Health;Registries;Research;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Resources;Risk Factors;Science;Scientist;screening;Secure;Socioeconomic Status;socioeconomics;South Africa;Speed;Statistical Methods;Strategic Planning;Surveys;Training;Trauma;Trauma patient;treatment services;Trust;Uganda;Universities;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Harnessing Data Science to Promote Equity in Injury and Surgery for Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-S(70)R]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE A national challenge in the biomedical sciences is recruiting, training, and retaining the most diverse scientific talent pool possible. At the University of Utah, we are poised to tackle this challenge by leveraging our recent successes in recruiting underrepresented students to our graduate programs and redoubling our efforts to develop targeted training and pipeline programs for underrepresented students to strengthen our applicant pool for graduate programs. We will expand the Biomedical Research Inclusion & Diversity to Grow Excellence in Science – Undergraduate program in Pathology for HBCUs and solidify key relationships with our local community and Historically Black Colleges and Universities in order to foster an inclusive, research-intensive environment where underrepresented scientists can flourish and attain their goal of admission to top-notch PhD training programs.

PI_NAMEs: FAIRFAX, KEKE CELESTE (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;Admission activity;African American student;Biomedical Research;Black Populations;Black race;career;Career Choice;career networking;college;Communication;Communities;Critical Thinking;cultural competence;Data;Dedications;design;Development;Disadvantaged;Discipline;Discrimination;diversity and inclusion;Doctor of Philosophy;Early Intervention;Educational workshop;empowerment;Environment;equity, diversity, and inclusion;expectation;experience;Faculty;faculty research;Family;Fortification;Fostering;Foundations;Goals;Graduate Education;graduate school;Growth;High School Student;Hispanic;Historically Black Colleges and Universities;Home;improved;Infrastructure;Institution;Knowledge;Leadership;Learning;Life;Malignant Neoplasms;matriculation;Mentors;Minority-Serving Institution;Mission;Modeling;notch protein;Oral;Outcome;Pathology;peer;peer coaching;Physicians;Population;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Privatization;programs;recruit;Research;Research Project Grants;Research Training;resilience;Role;role model;Science;Scientist;skill acquisition;skills;social;STEM career;Student recruitment;Students;success;summer program;Syndrome;Talents;Technical Expertise;tool;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Students;Universities;Utah;Workplace;Writing

PROJECT_TITLE: Biomedical Research Inclusion & Diversity to Grow Excellence in Science - Undergraduate Program in Pathology for HBCUs (BRIDGE-UP HBCU)


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Public health Relevance Polycystic Kidney Disease (PKD) is the most common inherited cause of renal failure worldwide. Despite significant progress in the field there is still no therapy that can reverse or cure PKD. That National Institutes of Health has established a PKD Research Consortium to accelerate research in PKD with the hope of identifying novel therapies. The goal of this proposal is to establish a National Coordinating Center that will provide administrative support to the PKD Research consortium with the goal of advancing translational science that will benefit patients with PKD.

PI_NAMEs: WATNICK, TERRY J (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acceleration;Address;Autosomal Dominant Polycystic Kidney;Belief;Biological Models;cohesion;cohort;Collaborations;collaborative environment;Communication;Communities;Creativeness;Critical Thinking;Cyst;Cystic Kidney Diseases;Data;Development;Disease;Education;Educational Activities;effective therapy;Evaluation;Event;experience;Fostering;Functional disorder;Funding;Funding Opportunities;Genes;Genomics;Goals;Human;improved;Information Dissemination;Inherited;innovation;insight;Intervention;Joints;Kidney Failure;Leadership;material transfer agreement;Mission;new therapeutic target;novel therapeutics;Patients;Polycystic Kidney Diseases;Positioning Attribute;programs;public health relevance;Reagent;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Science;Structure;success;symposium;Talents;tool;Translational Research;Translations;United States National Institutes of Health;web site

PROJECT_TITLE: National Coordinating Center (NCC) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Direct Targeting “loss-of-function” tumor suppressor is challenging and intuitively considered as “mission impossible”. In this proposal, using SMAD4 tumor suppressor as a case study, we propose to address the challenge in part through direct targeting a subgroup of “loss-of-interaction” SMAD4 mutations using small molecule mutant SMAD4-protein-protein-interaction inducers (MuSMADid). The small molecule MuSMADid discovery will provide a proof-of-concept for developing other small molecule PPI inducers for targeting the vast neglected tumor suppressor space.

PI_NAMEs: MO, XIULEI  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Amino Acid Substitution;Amino Acids;analog;anti-cancer;anticancer activity;assay development;Biochemical;Biological;Biological Assay;Cancer Biology;cancer cell;Case Study;Cell Cycle Arrest;cell growth;Cell Nucleus;Cell Proliferation;Cell Survival;Cells;Chemicals;cheminformatics;Collection;colon cancer cell line;Colon Carcinoma;Complex;Data;Development;Dose;druggable target;experience;extracellular;Fluorescence Resonance Energy Transfer;Future;gastrointestinal;Genetic Transcription;Genomic Library;genomic profiling;Glues;Goals;high throughput screening;Impairment;Intuition;Lead;lead optimization;loss of function;MADH3 gene;MADH4 gene;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediator;Missense Mutation;Mission;Monitor;mutant;Mutate;Mutation;neglect;novel;Oncogenic;Oncology;Pathway interactions;Performance;Pharmaceutical Chemistry;Phase;precision drugs;precision oncology;Proliferating;protein protein interaction;Recurrence;Research;Resolution;response;scaffold;Scientist;screening;Series;Signal Pathway;Signal Transduction;small molecule;small molecule libraries;small molecule therapeutics;Specificity;Subgroup;success;Suppressor Mutations;Testing;Therapeutic;Therapeutic Intervention;Time;Transforming Growth Factor beta;Triage;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Validation;Work

PROJECT_TITLE: Discovery of small molecule mutant SMAD4-PPI inducers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Glial-neuronal interactions underlie a broad range of aging-associated disease phenotypes in the nervous system and beyond. Activation of the heat shock response (HSR) has been shown to extend lifespan and promote healthy aging, but until this proposal, glial signaling of the HSR has never been examined. This proposal studies the mechanism by which glial stress response induction can extend lifespan, and further proposes extending this work using microglia/neuronal interaction in tauopathies to interrogate the ways in which microglia signal aging-related stress responses to protect neurons.

PI_NAMEs: GILDEA, HOLLY KATHERINE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acute;Address;Age;age related changes;aged;Aging;aging related;aging related disease;Alzheimer's Disease;biological adaptation to stress;Brain;brain cell;Caenorhabditis elegans;Cell Communication;Cell Compartmentation;Cell Culture Techniques;Cell Death;cell injury;Cells;Cessation of life;Chronic;Coculture Techniques;connectome;Cytosol;Data;Data Set;Dementia;Development;Disease;disease model;disease phenotype;Distal;Event;experience;extend lifespan;Failure;Functional disorder;Gene Expression Profile;Genes;Genetic;Health;healthspan;healthy aging;Heat shock proteins;heat shock transcription factor;Heat Stress;heat-shock factor 1;Heat-Shock Response;Homeostasis;Human;Image;Immune response;improved;in vivo;Inflammation;insight;Interneurons;Laboratories;life span;Link;Longevity;Maps;Measures;Mediating;Metabolic;Methods;Microglia;misfolded protein;model organism;Modeling;Molecular Chaperones;Monitor;mouse model;Mus;Mutagenesis;mutant;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuronal circuitry;neuronal survival;Neurons;neuroprotection;neurotoxic;neurotransmission;normal aging;novel;Organism;overexpression;Oxidative Stress Pathway;Pathology;Pathway interactions;Peripheral;Phenotype;programs;protein aggregation;protein folding;protein function;protein misfolding;Proteins;proteostasis;proteotoxicity;Receptor Signaling;Reporter;response;Role;Sampling;Signal Pathway;Signal Transduction;Stains;Stress;Synapses;System;tau aggregation;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Tissues;Toxic effect;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: The role of glia in monitoring neuronal proteostasis in aging