ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative. Insulin-degrading enzyme (IDE) is involved in cellular proteostasis and its dysregulation is implicated in several metabolic and neurodegenerative disorders. Our studies will characterize the structural and mechanistic basis of various proteolytic and nonproteolytic roles of IDE, thereby providing a molecular understanding of its multifunctionality, which will be beneficial for designing new therapeutic strategies to halt the progression of IDE- associated pathologies, including Alzheimer's disease.

PI_NAMEs: DESHMUKH, LALIT  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;abeta oligomer;Abeta synthesis;Acceleration;age related;Aging;Allosteric Regulation;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Antibodies;beta-Endorphin;biophysical analysis;biophysical techniques;Brain;Catabolism;Cerebrum;Characteristics;chemical kinetics;Chemicals;Clinical Research;Cognition Disorders;Complex;conformational conversion;Cryoelectron Microscopy;design;Deterioration;Development;dimer;Dissection;Endopeptidases;Environment;enzyme activity;Enzyme Inhibition;enzyme structure;Enzymes;Exhibits;Exocytosis;Fluorescence Spectroscopy;Foundations;Functional disorder;Genetic Polymorphism;Glucagon;Glucose Intolerance;Heat shock proteins;HIV;HIV-1;Human;Human Activities;In Vitro;innovation;insight;Insulin;insulin dimers;Insulinase;intermolecular interaction;islet amyloid polypeptide;Kinetics;Knockout Mice;Label;Late Onset Alzheimer Disease;Laws;Ligands;mathematical model;Mediating;Medical;Metabolic Diseases;Metalloproteases;Methods;methyl group;Microscopic;milligram;Molecular;Molecular Chaperones;Molecular Conformation;monomer;Neurodegenerative Disorders;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nucleotides;overexpression;Pathogenesis;Pathologic Processes;Pathology;Pathway interactions;Peptides;Persons;Physiological Processes;Play;Polyphosphates;prevent;Prevention;Production;Property;Proteins;Proteome;proteostasis;Relaxation;Research;Risk;Roentgen Rays;Role;Senile Plaques;Site;structural biology;Structure;System;Therapeutic;Variant;Zinc

PROJECT_TITLE: Mechanistic dissection of allosteric modulation and nonproteolytic chaperone activity of human insulin-degrading enzyme

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_CITY: AUSTIN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative Behavioral performance in perceptual tasks involves a complex and dynamic interplay between external inputs and internal states such as alertness, motivation and attention, which are regulated by several neuromodulatory systems. The overarching goal of the current proposal is to develop and test an optical- genetic toolbox for monitoring and controlling multiple interacting brain regions in awake, behaving non- human primates, focusing on neuromodulatory circuits that exert a powerful, yet poorly understood, impact on the cortical circuits that mediate perceptual decision-making. This toolbox will open the door for advanced studies that would lead to a deeper understanding of the neuromodulatory circuits which play an important role in many complex behaviors and are implicated in many human neuropathologies.

PI_NAMEs: DEISSEROTH, KARL A.;SEIDEMANN, EYAL J (contact)

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TITLE: An optical-genetic toolbox for monitoring and controlling diverse neuromodulatory circuits governing complex behaviors in primates


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: KANSAS CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Alcohol-associated liver disease is a major health problem accounts for approximately 40,000 deaths per year in the US. This project will examine the role that liver cells called Kupffer cells play in supporting and maintaining liver function during alcohol exposure. Understanding how alcohol specific Kupffer cells are able to protect the liver will allow development of therapies to reverse liver failure and accelerate recovery in patients who cease alcohol consumption.

PI_NAMEs: WEINMAN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Ablation;Abstinence;Acceleration;Acute;Acute Liver Failure;alcohol abstinence;Alcohol consumption;alcohol exposure;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Appearance;Biochemical;Cause of Death;Cell Communication;Cell Count;Cell Physiology;Cell secretion;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chronic;Collagen;Development;diphtheria toxin receptor;Disease;disease phenotype;drinking;effective therapy;Event;exosome;extracellular;extracellular vesicles;Family;Family member;fatty liver disease;feeding;Fibrosis;Gene Expression;Genetic Transcription;Goals;Grant;Growth Factor;Health;hepatic necrosis;Hepatitis;Hepatocyte;Histologic;Homeostasis;Human;IGF1 gene;immune cell infiltrate;Immunologics;improved;In Vitro;in vivo;Infiltration;Inflammation;Kupffer Cells;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver function;Liver Regeneration;liver transplantation;Macrophage;Matrix Metalloproteinases;member;Metabolic;MicroRNAs;Modeling;mortality;mouse model;Mus;nanocarrier;Outcome;Pathogenicity;Patients;Persons;Phenotype;Play;Population;Process;progenitor;Proliferating;Property;Protocols documentation;Recovery;Resolution;restoration;RNA-Binding Proteins;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Steatohepatitis;stem cells;stemness;Techniques;Technology;Testing;Therapeutic Intervention;therapy development;Time;Tissues;western diet;Work

PROJECT_TITLE: Role of alcohol adapted Kupffer cells in the progression and resolution of ALD

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Disrupted primary cilia signaling and the resultant changes in neuronal circuit formation and function lead to brain malformations and neurodevelopmental disorders, including autism, schizophrenia, and epilepsy. We plan to precisely and comprehensively delineate primary cilia driven signaling mechanisms animating neuronal function and malfunction in the cerebral cortex. Understanding the molecular logic of primary cilia's role in neuronal functional dynamics and the relevance of this paradigm for neural circuit malfunction will enable us to use primary cilia signaling as a tool to mend neural circuit disorders.

PI_NAMEs: ANTON, EVA S (contact);LICHTMAN, JEFF W;YASUDA, RYOHEI

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Animals;animation;Anosmia;Apraxia;Ataxia;autism spectrum disorder;Axon;Brain;brain malformation;Bronchiectasis;Cell Nucleus;Cerebral cortex;Cilia;ciliopathy;Collaborations;Congenital Heart Defects;connectome;Cystic kidney;Defect;Dendrites;design;Development;Developmental Delay Disorders;Disease;Epilepsy;experimental study;Face;gene network;Genetic;genetic approach;Genetic Transcription;Goals;Health;hearing impairment;Hepatic Cyst;Human;human model;Image;Infertility;innovation;insight;Intellectual functioning disability;Knowledge;Lead;Live Birth;Logic;Maintenance;Maps;Microtubules;Modeling;Molecular;Monitor;Mood Disorders;multimodality;Nervous System Disorder;neural circuit;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Neurophysiology - biologic function;neurotransmission;novel;novel therapeutics;Obesity;optical imaging;optogenetics;Organ;Organelles;Organoids;Outcome;Pancreatic Cyst;Pathway interactions;Physiological;Polydactyly;programs;real-time images;reconstruction;Recovery of Function;repaired;Research;response;Retinal Degeneration;Role;Schizophrenia;Sensory;Services;Shapes;Signal Transduction;Situs Inversus;Technology;Testing;Therapeutic;Time;tool;transcriptomics;transmission process;Work

PROJECT_TITLE: Primary Cilia: A Novel Signaling Gateway To Neural Circuit Modulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_STATE: CA

PHR: PROJECT NARRATIVE Blood-forming stem cells in the bone marrow regenerate blood and immune cells throughout life. Defects in stem cell maintenance that occur during aging lead to anemia, impaired immunity and leukemia, but the underlying cause of these defects is largely unknown. This proposal will examine if blood-forming stem cell maintenance and fitness is disrupted by the accumulation of aggregated protein, and will identify unique pathways used by stem cells to limit protein aggregation and enhance longevity.

PI_NAMEs: SIGNER, ROBERT A.J. (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;age related;age related decline;Age related pathologies;age-related disease;Aging;Anemia;Autophagocytosis;BAG3 gene;Biogenesis;biological adaptation to stress;Blood;Blood Cells;Bone Marrow;Bone marrow failure;Cell Differentiation process;Cell Maintenance;Cells;Data;Defect;Degradation Pathway;Disabling;Disease;Exhibits;fitness;fluorescence imaging;Functional disorder;Gene Expression;Genetic;Goals;healthspan;Hematological Disease;Hematopoiesis;Hematopoietic Neoplasms;hematopoietic stem cell aging;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Human;Immune;Immunity;Impairment;in vivo;Inclusion Bodies;Injury;Knockout Mice;Lead;leukemia;Life;Longevity;Malignant - descriptor;Malignant Neoplasms;misfolded protein;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;Natural regeneration;Non-Malignant;older adult;Outcomes Research;Pathway interactions;preservation;prevent;progenitor;programs;Proliferating;protein aggregation;Protein Biosynthesis;protein degradation;proteostasis;proteostasis loss;proteotoxicity;regenerative;Resources;response;self-renewal;sensor;stem cell function;stem cells;Stress;System;TAL1 gene;Testing;Tissues;Ubiquitin

PROJECT_TITLE: Protein homeostasis in hematopoietic stem cells

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE (Overall) The Stanford Alzheimer's Disease Research Center supports the National Alzheimer's Project Act by serving as a shared resource to promote research on Alzheimer's disease, cognitive impairment linked to Lewy body changes in the brain, and cognitive aging.

PI_NAMEs: HENDERSON, VICTOR  (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Adult;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Artificial Intelligence;Big Data;Bioinformatics;Biological Markers;Biometry;Blood;Brain;Brain imaging;brain tissue;Cell Line;Cells;Clinical;Clinical Management;Cognitive aging;community engagement;community partners;Consent;Consultations;Data;data management;Data Set;Dementia with Lewy Bodies;Development;Diagnosis;Disease;disparity reduction;Early Diagnosis;Education;ethnic minority population;Family;Feces;Fibroblasts;Foundations;Funding;Future;Goals;high risk;Hispanic;Human Resources;Image;Immune;Impaired cognition;improved;innovation;insight;investigator training;Latino;Lewy Bodies;Lewy body pathology;Lewy neurites;Link;Liquid substance;Meninges;microbiome;Mission;Molecular;motor impairment;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging marker;neuropathology;older adult;outreach;Parkinson Disease;Participant;Pathogenesis;Pathologic;pathological aging;Persons;Phenotype;Plasma;Population;pre-clinical;prevent;Proteomics;racial minority population;recruit;repository;Research;Research Personnel;Research Support;Research Training;resilience;Resistance;Resource Sharing;Resources;Risk;Skin;Solid;statistics;stool sample;Structure;Therapeutic;tool;Training;Training Support;whole genome


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Adopted;age related;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Biological;Brain;Caregivers;Caring;Clinical;Cognition;Collaborations;Communities;Data;data exchange;data storage site;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;disparity reduction;Early Diagnosis;Education;Ensure;ethnic minority population;Evaluation;Genetic;Goals;Guidelines;Health Professional;high risk;Hispanic;Impaired cognition;improved;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;Latino Population;Leadership;Lewy Bodies;Lewy body pathology;Lewy neurites;Link;Microscopic;mild cognitive impairment;Mission;Monitor;National Institute on Aging;Nerve Degeneration;Neurofibrillary Tangles;next generation;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic;Pathology;Persons;Phenotype;Policies;pre-clinical;prevent;Procedures;Process;racial minority population;Reporting;repository;Research;Research Personnel;Resource Sharing;Resources;Risk;Specimen;Structure;Time;Training;United States National Institutes of Health;Universities;Update

PROJECT_TITLE: Administrative Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE The University of California, San Francisco Training in Reproducible Research on Aging for Social Science and Epidemiology (UCSF-TRASE) program will develop, launch, evaluate, refine, and disseminate, intensive short courses on reproducible research perspectives and skills. The short course modules will address core concepts for reproducible research; reproducible research at the data analysis stage; reproducibility considerations for data collection; and meta-science for triangulation to enhance reproducibility.

PI_NAMEs: CHAN, JUNE ML (contact);JIANG, FEI

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Active Learning;Address;Administrator;Aging;aging population;Applications Grants;Attitude;Behavioral;behavioral and social science;Behavioral Research;Benchmarking;Big Data;Biometry;Black Box;California;career;Code;Cognition;Communities;Complex;complex data;computing resources;course module;Critiques;Data;Data Analyses;Data Collection;data quality;Data Set;Data Sources;disability;Discipline;dissemination strategy;Documentation;Ecosystem;Educational Curriculum;Elements;Epidemiology;Evaluation;Face;Fostering;Foundations;hands-on learning;Health;health disparity;healthy aging;Hybrids;Hygiene;Interdisciplinary Study;journal article;Learning;Learning Module;learning strategy;Measures;Mental Depression;Methodology;Nature;older adult;Participant;Persons;Physicians;population health;Postdoctoral Fellow;Preparation;Professional Role;programs;Proliferating;Protocols documentation;Publications;Publishing;Quality Control;racism;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Training;response;San Francisco;satisfaction;Science;Scientific Advances and Accomplishments;Scientist;Sea;self-directed learning;Series;skills;social;social epidemiology;social integration;social science research;Social Sciences;symposium;Technical Expertise;Techniques;tool;Trainers Training;Training;Training Activity;Training Programs;Universities;Work

PROJECT_TITLE: Short Courses on the Conduct of Reproducible Aging Research with Big Data


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

PROJECT_TERMS: Acceleration;Adherence;Adopted;Adult;Age;Aging;Agreement;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Amyloid beta-Protein;amyloid imaging;Behavior assessment;Behavioral;Biological Markers;Brain;Catchment Area;Categories;Clinical;Clinical assessments;Clinical Trials;Cognitive;Cognitive aging;cognitive testing;cohort;Consensus;Consent;Data;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;Disease;education research;Enrollment;Environment;Ethnic Population;Faculty;Family history of;First Degree Relative;follow-up;Funding;Genetic;Goals;graduate student;Grant;Hispanic;Image;Immune System Diseases;Impaired cognition;Individual;insight;Latino;Lewy Bodies;Magnetic Resonance Imaging;Measures;Medical Research;Medical Students;mild cognitive impairment;Minority Enrollment;motor impairment;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neurologic;neuropathology;older adult;outreach;Parkinson Disease;Parkinson's Dementia;Participant;participant enrollment;participant retention;Pathogenesis;Patients;Phenotype;Population;Population Control;Populations at Risk;Positron-Emission Tomography;pre-clinical;protein misfolding;Protocols documentation;Qualifying;recruit;Research;Research Personnel;Research Support;resilience;Resistance;Resources;Risk;tau Proteins;Therapeutic;Time;Training;Work

PROJECT_TITLE: Clinical Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: TOLEDO

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: Insulin, a hormone that rises in response to food intake and accumulating body fat stores, is known to promote early puberty and fertility by acting in the brain, but extensive research has not determined the neurons involved. New, exciting data from our lab indicates that non-neuronal cells called astrocytes sense insulin to permit normal reproductive hormone release. These studies will determine the underlying mechanisms so that novel therapies can be developed to treat infertility related to diabetes mellitus, obesity, and other metabolic disorders.

PI_NAMEs: HILL, JENNIFER WOOTTON (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Adult;Age;Anabolism;Antral;Astrocytes;Biological;Blood - brain barrier anatomy;Body fat;Brain;Breeding;Calories;Cell Line;Cells;Communication;Coupling;cyclooxygenase 2;Data;Defect;Delayed Puberty;Diabetes Mellitus;diabetic;Dinoprostone;Drops;Eating;Enzymes;Female;Fertility;Food deprivation (experimental);Genes;Genetic;Genetic Transcription;girls;Glial Fibrillary Acidic Protein;glucose uptake;Goals;Gonadotropin Hormone Releasing Hormone;Homeostasis;Hormones;Idiopathic Hypogonadotropic Hypogonadism;Impairment;Improve Access;in vivo;Individual;Infertility;Insulin;Insulin Receptor;Insulin Resistance;insulin signaling;Insulin Signaling Pathway;Insulin-Like Growth Factor I;Intermediate Filament Proteins;KISS1 gene;Klinefelter's Syndrome;Leptin;male;Measurement;Measures;men;Menarche;Metabolic;Metabolic Diseases;Metabolic hormone;Molecular;Mus;nerve stem cell;nestin protein;neurochemistry;Neuroglia;Neurons;Neurosecretory Systems;novel therapeutics;Nutrient;Obesity;obesity in children;Pathway interactions;Patients;peripubertal period;Phosphorylation;Play;Population;postsynaptic;Preoptic Areas;presynaptic;Presynaptic Terminals;Production;promoter;Prostaglandin-Endoperoxide Synthase;pubertal timing;Puberty;Radial;regenerative;Reproduction;reproductive;reproductive axis;reproductive function;reproductive hormone;Research;response;Role;sensor;sex;Signal Pathway;Signal Transduction;spatiotemporal;Sperm Count Procedure;Strenuous Exercise;Structure of nucleus infundibularis hypothalami;success;Synapses;System;Testing;Therapeutic;Time;transcription factor;Viral;Western Blotting;Woman;Work

PROJECT_TITLE: Astrocyte insulin resistance-induced neuroendocrine defects in pubertal delay and hypogonadotropic hypogonadism


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ATLANTA

ORG_NAME: LENA BIOSCIENCES, INC.

ORG_STATE: GA

PHR: This project will lay out foundation for new, alternative, animal-relevant test systems for sensitive, reliable and predictive in vitro testing of environmental toxicants, such as organophosphate and carbamate pesticides, to ethically and humanely identify potential hazards to human health and the environment.

PI_NAMEs: VUKASINOVIC, JELENA  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 3-Dimensional;Acetaminophen;acetaminophen overdose;Acetylcholine;Acetylcholinesterase;Ache;Acute;Agrochemicals;Analgesics;Animal Experiments;Animal Testing;animal tissue;Animals;Benchmarking;Biochemical;Biological;Biological Assay;Biological Sciences;Biology;Black Box;Blood Substitutes;Boronic Acids;Brain;Breathing;Carbamates;carboxylesterase;Cell Culture Techniques;Cell Respiration;Cells;Cessation of life;Chemicals;commercialization;Competence;Complex;cost;Data;Development;Dose;drug induced liver injury;Drug Interactions;Drug Metabolic Detoxication;drug metabolism;drug testing;Ensure;Environment;Environmental Health;Enzyme Inhibition;Enzymes;esterase;Ethics;Evaluation;Exposure to;Foundations;Free Radicals;Galactose;Generations;Glycolysis;Goals;hazard;Health;Hemoglobin;Hepatocyte;HepG2;high throughput screening;Human;In Situ;In Vitro;in vitro Model;in vitro testing;in vivo;in vivo Model;inhibitor;Insecta;Insecticides;interstitial;invention;Kansas;Lactate Dehydrogenase;Liquid substance;Liver;malaoxon;Malathion;Medical center;Metabolic;Metabolism;Methods;microphysiology system;Mitochondria;mitochondrial metabolism;Modeling;multiplex assay;Mus;N-acetyl-4-benzoquinoneimine;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;Natural Immunity;Neuromuscular Junction;Neuropathy;neuropathy target esterase;neurotoxic;neurotoxicity;Normal Cell;Organ;Organ Culture Techniques;organ on a chip;Organophosphates;organophosphorus insecticide;Outcome;Overdose;oxidation;Oxidative Phosphorylation;Oxidative Stress;Oxygen;Paralysed;Parents;Perfusion;Pesticides;Pharmaceutical Preparations;Pharmacology;Phase;Physiological;Plasma;Predisposition;Process;Production;programs;Protein Isoforms;Publishing;Pyruvate;Qualifying;Reporting;Research;Resistance;respiratory;response;Risk;Rodent;Rotenone;screening;Sensitivity and Specificity;Small Business Innovation Research Grant;success;System;Technology;Testing;three-dimensional modeling;Tissue Model;Toxic effect;Toxic Environmental Substances;toxicant;Toxicity Tests;Toxicology;United States Environmental Protection Agency;Universities;Validation;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Perfused organ panel as an animal surrogate for chemical toxicity testing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: TIAN, LU  (contact)

PROJECT_TERMS: Alzheimer's Disease;analytical method;analytical tool;Authorization documentation;Bioinformatics;Biometry;Clinical Research;cohort;Collaborations;Collection;Consultations;Data;Data Analyses;data integration;data management;Data Management Resources;Data Set;Data Storage and Retrieval;Database Management Systems;Databases;Development;Disease;Education;education research;electronic data;Enrollment;follow-up;Grant Review;improved;innovation;Manuscripts;Methodology;Mission;multiple data sources;multiple datasets;Paper;Participant;Phenotype;Postdoctoral Fellow;Quality Control;Reaction Time;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;screening;statistics;Summary Reports;tool;Training and Education;web portal;Work;Writing

PROJECT_TITLE: Data Management and Statistics Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOPHYSICS

PHR: PUBLIC HEALTH RELEVANCE: Ultrasonic neuromodulation is a promising new technology that has the potential to provide revolutionary new therapies for neurological disorders including Parkinson's disease, dystonia, epilepsy, Alzheimer's, anxiety, schizophrenia, and stroke. However, use of this technology is impeded by the limited understanding of the mechanism by which ultrasound stimulates brain activity. The proposed research will provide a mechanistic understanding necessary to catalyze development of ultrasonic neuromodulation therapies.

PI_NAMEs: BACCUS, STEPHEN A;BUTTS-PAULY, KIM ;KHURI-YAKUB, BUTRUS T;MADUKE, MERRITT C (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Acoustics;Action Potentials;Acute;Address;Alzheimer's Disease;Animals;Anxiety;Behavior;Behavioral;Biological;Biological Models;biological systems;Biophysical Process;Biophysics;Brain;Brain Diseases;cell type;Cells;Clinical;Complex;Data;Development;Dystonia;Epilepsy;experimental study;Goals;Grant;Health Care Costs;hippocampal pyramidal neuron;Hippocampus;Implanted Electrodes;In Vitro;in vitro activity;in vivo;individual response;insight;Interdisciplinary Study;Ion Channel;Lead;Measurable;Measurement;Measures;Mechanics;Mediating;Mental disorders;millimeter;Modality;Modeling;Molecular;Motor Cortex;mouse model;Mus;Nervous System Disorder;neural;neural circuit;neural network;Neural Retina;Neurobiology;neuromechanism;Neurons;neuroregulation;Neurosciences;new technology;novel therapeutics;Outcome;Output;Parkinson Disease;Penetration;physical process;Physiologic pulse;predicting response;predictive modeling;Preparation;Process;Prosthesis;Public Health;public health relevance;Pyramidal Cells;Radiation;Rattus;Reporting;Research;Research Project Grants;Resolution;response;Retina;Retinal Ganglion Cells;retinal stimulation;Salamander;Schizophrenia;sight restoration;Slice;spatial integration;spatiotemporal;Stroke;Structure;Synaptic Transmission;System;Techniques;Technology;Temperature;Testing;Tissues;tool;Transcranial magnetic stimulation;Translating;Ultrasonics;ultrasound;Vision

PROJECT_TITLE: Neurostimulation by Ultrasound: Physical Biophysical and Neural Mechanisms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: COBOS, INMA  (contact)

PROJECT_TERMS: aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Autopsy;Award;biobank;Biological Assay;Biological Markers;Brain;Brain region;brain research;brain tissue;Clinical;Cognitive;Consensus;Country;Data;data management;data quality;Dementia;Development;Diagnostic;diagnostic criteria;Discipline;Disease;education research;Educational process of instructing;empowerment;Environment;Evaluation;Faculty;Formalin;Fostering;Freezing;Future;graduate student;Guidelines;Image;imaging approach;Impaired cognition;Individual;innovation;innovative technologies;insight;Interdisciplinary Study;International;Leadership;Medical Students;Methods;Mission;Molecular;molecular pathology;multidisciplinary;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Outreach Research;Paraffin Embedding;Pathologic;Pathologic Processes;Patients;Physicians;Positioning Attribute;Process;Reporting;repository;Research;Research Personnel;research study;Resource Sharing;Scientist;Specimen;statistics;Structure;Techniques;Technology;Tissue Embedding;Tissues;Training;Translational Research;Vision

PROJECT_TITLE: Neuropathology Core


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: RELEVANCE STATEMENT The way different kinds of cells express various genes at various times and in various amounts is determined largely during early organism development and often relies on proteins known as transcription factors. However, this control of gene expression can also be driven by dynamic interactions between the structures of the nucleus and the structures around the genes – particularly chromatin. Here we will study how nuclear proteins called nucleoporins purposefully link chromatin organization and remodeling to control of gene expression in certain cell types so that we can understand how they function in both health and disease.

PI_NAMEs: WEST, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Architecture;Auxins;Binding;Biological Assay;Catalytic Domain;CCCTC-binding factor;Cell division;Cell Nucleus;cell type;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosome Structures;cohesin;Coupling;CRISPR/Cas technology;Defect;Development;Disease;DNA Polymerase II;Electron Microscopy;embryonic stem cell;Euchromatin;Exhibits;Gene Activation;Gene Expression;Gene Expression Regulation;Gene Order;Gene Structure;Genes;genetic regulatory protein;Genetic Transcription;Genome;Genome Stability;genome-wide;Genomics;Goals;HCT116 Cells;Health;histone modification;Human;Image;imaging study;insight;Knowledge;Link;Mammalian Cell;Maps;Mediating;Microscopy;Molecular;Mouse Embryonic Stem Cells;Nuclear;Nuclear Envelope;Nuclear Lamina;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Proteins;Nuclear Structure;Nucleoplasm;Organism;Pattern;Peripheral;Positioning Attribute;Precision Run-On Sequencing;Process;programs;protein complex;Proteins;Publishing;Reaction;Regulation;Regulatory Element;Role;Signal Transduction;Site;SMARCA4 gene;Structure;SWI/SNF Family Complex;System;Testing;transcription factor;Transcriptional Activation;Transcriptional Regulation;Work

PROJECT_TITLE: MECHANISMS OF CHROMATIN STRUCTURE AND TRANSCRIPTION REGULATION BY THE NUCLEAR PORE COMPLEX

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ROSAS, LISA GOLDMAN (contact)

PROJECT_TERMS: Address;Advance Care Planning;Advocacy;advocacy organizations;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Awareness;bench to bedside;bilingualism;burden of illness;Caring;caucasian American;Caucasians;Characteristics;Clinic;Clinical;Clinical Research;cohort;Collaborations;Communities;community advisory board;Community Health;Community Health Aides;Community Healthcare;community organizations;Community Outreach;community partners;comparative;Country;County;Dementia;dementia burden;dementia risk;design;Diabetes Mellitus;Diagnosis;Disease;Documentation;Education;education research;Educational workshop;empowerment;Enrollment;Ethnic Population;Event;Faith-based organization;Federally Qualified Health Center;Feeling;Female;First Degree Relative;forging;Friends;Funding;Goals;Government;Government Agencies;Health;health care service organization;health disparity;health organization;Health Personnel;Healthcare Systems;healthy aging;high risk population;Hispanic;Hospitals;Impairment;innovation;insight;instrumental activity of daily living;Juglans;Knowledge;Latino;Latino Population;learning materials;Lewy Bodies;literacy;low health literacy;male;Medicine;Memory;Mexican;Mexican Americans;Mexico;mild cognitive impairment;Minority;Neighborhood Health Center;Neurobehavioral Manifestations;news;Newsletter;next generation;novel;older adult;outreach;Pain;palliative;Participant;participant retention;Patient Recruitments;Patients;Persons;Population;Population Heterogeneity;Preventive;Preventive measure;Printing;Public Health;racial population;Radio;recruit;Registries;Research;Research Personnel;Research Project Grants;Resources;retention rate;Risk Factors;screening;sex;Sister;social media;sociocultural determinant;sociodemographics;Spanish/English;Supportive care;synergism;Television;Time;Training;unconscious bias;Vulnerable Populations;Walking;web site;Work

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Microbiome;Neurodegenerative;Neurosciences

PI_NAMEs: WYSS-CORAY, TONY  (contact)

PROJECT_TERMS: Algorithmic Analysis;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;analysis pipeline;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;Biology;biomarker performance;Blood;Blood Cells;Cardiovascular Diseases;Cells;Clinical;Clinical Management;Collaborations;Collection;Cytometry;Data;Data Analyses;data management;Data Set;data sharing;Databases;Dedications;Dementia;Detection;Development;Diabetes Mellitus;Disease;DNA;Equipment and supply inventories;experience;Feces;Fibroblasts;Gene Expression Profile;Genetic;genetic variant;Glial Fibrillary Acidic Protein;Goals;gut microbiome;Human;Image;imaging modality;Immune;Individual;Information Dissemination;Light;Liquid substance;Measurement;Measures;member;Methods;microbiome;Mission;Molecular;molecular marker;multiple omics;Nerve Degeneration;Neurodegenerative Disorders;neurofilament;neuropathology;next generation;novel;novel marker;novel therapeutics;Parkinson Disease;Parkinson's Dementia;Participant;Pathologic Processes;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Populations at Risk;Process;Proteome;Proteomics;public database;Publishing;Quality Control;receptor expression;Reproducibility;Research;Research Personnel;research study;RNA;Sampling;Sensitivity and Specificity;Serum;Signal Transduction;Skin;skin microbiome;Source;Standardization;stool sample;T-Cell Receptor;tau Proteins;tau-1;Technology;Tissues;tool;Training Support;transcriptome;transcriptome sequencing;transcriptomics;web portal;whole genome;Work

PROJECT_TITLE: Biomarker Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Dietary Supplements;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Precision Medicine;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Approximately 10% of U.S. adults aged 65+ has Alzheimer's disease and related dementias. This project seeks to identify taxonomic and function features of the gut microbiome and fecal metabolites of microbial origin that explain inter-individual differences in the associations of healthy dietary patterns with cognitive function and risk of Alzheimer’s dementia in three studies of ~1,5000 participants. Based on the unique resources, the proposed research will provide foundational knowledge for maximizing the benefits of dietary approaches, discovering novel biomarkers, and ultimately contributing to precision dietary prevention of Alzheimer's dementia.

PI_NAMEs: WANG, DONG  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta accumulation;Acids;Address;Adherence;adjudication;Adult;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amines;Amyloid;Amyloid beta-42;Animal Model;Bifidobacterium;Bile Acids;Bioinformatics;Biological Markers;Biometry;blood-brain barrier permeabilization;brain magnetic resonance imaging;Brain-Derived Neurotrophic Factor;Branched-Chain Amino Acids;Butyrates;Cognition;Cognitive;cognitive function;Cohort Studies;cost efficient;Data;Dementia;Deoxycholic Acid;design;Diet;dietary;dietary approach;Dietary Assessment;Dietary Intervention;Dietary Practices;Enzymes;Epidemiology;Flavonoids;follow-up;gamma-Aminobutyric Acid;Genetic Transcription;Glial Fibrillary Acidic Protein;gut microbiome;gut microbiota;Health;high risk;Human;Human Microbiome;human old age (65+);Impaired cognition;improved;indexing;Individual;Individual Differences;individual variation;individualized prevention;insight;Intervention;Knowledge;Kynurenine;Lactobacillus;Light;Link;Magnetic Resonance Imaging;Measures;Mediating;Mediterranean Diet;Metabolic;Metabolism;metabolomics;Metagenomics;metatranscriptomics;microbial;microbial composition;Microbial Taxonomy;microbiome;mild cognitive impairment;Molecular;molecular phenotype;Nerve Degeneration;neurofilament;neuroinflammation;Neurology;Neurotransmitters;novel;novel marker;Nurses' Health Study;nutrition;Outcome Assessment;Oxides;Participant;Peptides;personalized approach;Plasma;Population;Positioning Attribute;precision medicine;precision nutrition;predictive marker;Prevention;Production;Prospective Studies;Randomized;randomized trial;Reporting;Reproducibility;Research;Research Design;Research Priority;Resolution;Resources;response;Risk;Role;Shotguns;stool sample;systemic inflammatory response;Taxonomy;Technology;Time;Volatile Fatty Acids

PROJECT_TITLE: Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive Function

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MORMINO, ELIZABETH  (contact)

PROJECT_TERMS: accurate diagnosis;Alzheimer's Disease;Amyloid;Behavioral;Binding;Biological Markers;Brain;Brain imaging;Caliber;Categories;Cerebrospinal Fluid;Classification;Clinical;clinical phenotype;Clinical Research;Collaborations;Consult;Consultations;cranium;Data;data management;Databases;demographics;Diagnosis;Diagnostic;diagnostic accuracy;Discipline;Discipline of Nuclear Medicine;Educational workshop;Eligibility Determination;Enrollment;Ensure;flexibility;Functional Imaging;Functional Magnetic Resonance Imaging;Generations;Genetic;glial activation;Goals;gray matter;Hippocampus;Human Resources;Image;Image Analysis;Immunohistochemistry;improved;in vivo;Infrastructure;innovation;Ligands;Link;Magnetic Resonance Imaging;Measures;Mentors;Modeling;molecular imaging;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;Neurites;Neurodegenerative Disorders;neuropathology;Neuropsychology;novel;Nuclear Radiology;Participant;Pathogenesis;Persons;Plasma;Positron-Emission Tomography;pre-clinical;Process;Proteins;Proteomics;Radiochemistry;Radiology Specialty;Reading;Research;Research Personnel;Resolution;Rest;Scanning;Schools;skills;Source;statistics;structural imaging;tau Proteins;Testing;Thick;tool;Training;training opportunity;Treatment Efficacy;willingness;Work;β-amyloid burden

PROJECT_TITLE: Imaging Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ALBANY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Narrative We propose to develop a class of potent, selective and chemically modified RNA aptamers that inhibit AMPA receptors, and test their efficacy and safety in the AR2 mouse that models sporadic ALS, where motor neurons undergo selective neurodegeneration triggered by excessive activity of AMPA receptors. If successful, our research will produce a novel RNA-based drug candidate for a potential ALS therapy.

PI_NAMEs: NIU, LI  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Acids;ALS patients;AMPA Receptors;Amyotrophic Lateral Sclerosis;amyotrophic lateral sclerosis therapy;Animal Model;Animal Testing;antagonist;aptamer;Behavior;Biological;Biological Assay;Blood - brain barrier anatomy;Blood capillaries;blood-brain barrier penetration;Body Weight;Brain;Brain Stem;Bypass;Cell Death;Cell Nucleus;Central Nervous System;Cessation of life;Chemicals;Circulation;Cytoplasm;design;Diffuse;Disease;DNA-Binding Proteins;Dose;Down-Regulation;drug candidate;drug development;drug discovery;Drug or chemical Tissue Distribution;dsRNA adenosine deaminase;early detection biomarkers;efficacy evaluation;efficacy testing;Enzymes;Epilepsy;Evolution;Failure;FDA approved;Functional disorder;Glutamates;Goals;Half-Life;Immunohistochemistry;In Vitro;in vivo;Individual;Infusion procedures;inhibitor;Injections;Intestinal Absorption;Ion Channel;Knockout Mice;Label;Ligands;lipophilicity;Liquid substance;Mediating;Metabolic Clearance Rate;Modeling;Monitor;motor disorder;Motor Neurons;mouse model;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurosciences Research;novel;Onset of illness;Outcomes Research;Pathology;Patients;Permeability;Pharmaceutical Preparations;prevent;Property;Protein Isoforms;protein TDP-43;receptor;receptor function;Research;research clinical testing;Resistance;response;Rest;Ribonucleases;Riluzole;RNA;RNA Editing;Safety;side effect;Site;small molecule;small molecule inhibitor;Spinal Cord;sporadic amyotrophic lateral sclerosis;Stroke;Survival Rate;Synaptic Transmission;Testing;Therapeutic;therapy development;Toxic effect;Transgenic Mice;Treatment Efficacy;Water;water solubility;Whole-Cell Recordings;Work

PROJECT_TITLE: Animal testing of RNA aptamers as ALS drug candidate

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative My academic research career in the field of neurodegenerative disease spans 30 years, beginning with my discovery of the first CAG – polyglutamine repeat expansion as the cause of an inherited neurological disorder, extending to 22 years as an independent investigator who has worked primarily on three polyglutamine repeat diseases (X-linked spinal & bulbar muscular atrophy [SBMA]; spinocerebellar ataxia type 7 [SCA7]; and Huntington’s disease [HD]), and including 20 years of continuous R01 funding from NINDS, with two currently active R01 grants. I have recently published a number of significant papers that advanced our understanding of these disorders, demonstrating skeletal muscle expression of mutant androgen receptor as a primary driver of SBMA motor neuron disease in a series of independent studies, documenting PPARd dysfunction in HD pathogenesis, confirming a role for PPARd in normal CNS function, and establishing PPARd agonist therapy as a potential HD treatment. I now request funding through the Outstanding Investigator Award mechanism to continue my dynamic and wide-ranging investigations into the cellular and molecular basis of polyglutamine neurodegeneration, as I seek to define the molecular basis of SBMA skeletal muscle-driven motor neuron degeneration, delineate how PPARd activation achieves neuroprotection, determine if processes of NMJ dysfunction or overexuberant activity-dependent gene expression may be relevant to more common neurodegenerative diseases, including ALS and AD, and seek to develop novel therapies that will restore homeostasis pathways that decline in function with aging and are markedly diminished in neurodegeneration.

PI_NAMEs: LA SPADA, ALBERT R (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Aging;Agonist;Androgen Receptor;AR gene;Area;Award;Bacterial Artificial Chromosomes;CAG repeat;career;Cerebral cortex;Communication;Corpus striatum structure;Development;Disease;disease phenotype;Excision;flexibility;follow-up;functional decline;Functional disorder;Funding;Gene Expression;Genetic Transcription;graduate student;Grant;Homeostasis;Huntington Disease;Huntington gene;Inherited;Investigation;Link;Lower Motor Neuron Disease;Metabolic;Microglia;mitochondrial dysfunction;Molecular;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse model;Mus;Muscular Atrophy;mutant;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuromuscular;Neuromuscular Junction;Neurons;neuroprotection;neurotoxicity;novel;novel therapeutics;Paper;Pathogenesis;Pathway interactions;Patients;Phenotype;polyglutamine;PPAR delta;prevent;Process;programs;Publishing;Regulation;Repression;Research;research and development;Research Personnel;response;Role;Series;Skeletal Muscle;skeletal muscle wasting;spinal and bulbar muscular atrophy;stem cell model;stem cells;Testing;therapy development;Time;Transcription Coactivator;transcriptome;Transgenes;Transgenic Mice;Translational Research;Type 7 Spinocerebellar Ataxia;Work

PROJECT_TITLE: La Spada Outstanding Investigator Award


PI_NAMEs: POSTON, KATHLEEN LOMBARD (contact)

PROJECT_TERMS: Affect;Age;Age Years;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Basic Science;Clinical;clinical center;Clinical Research;Cognitive aging;Collaborations;Communities;Competence;Complement;Complex;Creativeness;Dedications;Dementia;Development;Discipline;Diverse Workforce;Education;education research;Enrollment;Ensure;experience;Faculty;Fellowship;Foundations;frontier;Future;Geriatric Psychiatry;Gerontology;Goals;Image;Individual;innovation;interdisciplinary approach;Interdisciplinary Study;K-Series Research Career Programs;Knowledge;Leadership;Lewy Bodies;Manuscripts;Mental disorders;Mentors;Mentorship;Methodology;Mission;Movement Disorders;multidisciplinary;Neurology;neuropsychiatry;Neurosciences;next generation;Participant;Population;Postdoctoral Fellow;programs;Psychiatry;Psychology;Public Health;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Scientist;statistics;Stress;Structure;Students;success;Training;training opportunity;Training Programs;Translational Research;Underrepresented Minority;Universities;Vision;Work

PROJECT_TITLE: Research Education Component (RL5)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The proposed research examines how multi-level factors contribute to disparities in health-related quality of life and survivorship care in diverse populations of young adult cancer survivors. During my dissertation research (F99 phase), I focus on the collaborative management of cancer among ethnically diverse survivor-caregivers. During the K00 phase, I will extend this research and training by developing expertise in understanding healthcare system and policy-level factors that contribute to disparities in cancer survivorship.

PI_NAMEs: OCHOA-DOMINGUEZ, CAROL  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acculturation;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;adverse outcome;Affect;Aftercare;Applied Skills;Area;Award;cancer care;Cancer Control;cancer health disparity;cancer prevention;Cancer Survivor;Cancer Survivorship;care giving burden;Caregivers;caregiving;Caring;Child;Child Mental Health;Childhood;childhood cancer survivor;Chronic;Communication;Communities;comorbidity;Data Analyses;Decision Making;depressive symptoms;Disparity;Emotional;ethnic diversity;ethnic minority;ethnic minority population;experience;Family;family influence;follow-up;Funding;Goals;Health;health disparity;health equity;health management;health related quality of life;Healthcare Systems;high risk;High-Risk Cancer;Hispanic;Immigration;Impaired health;Impairment;improved;improved outcome;Individual;interest;Intervention Studies;Interview;Knowledge;Late Effects;Latino;Latino Population;Learning Skill;Linguistics;Literature;Long Term Survivorship;Long-Term Care;Long-Term Effects;Los Angeles;Malignant Childhood Neoplasm;Malignant Neoplasms;Managed Care;marginalized population;Medical;Medical Care Team;Mental Health;Mentors;Minority;mortality;Not Hispanic or Latino;older adult;Outcome;parental role;Parents;Phase;Pilot Projects;Play;Policies;Population;population based;population health;Population Heterogeneity;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;primary caregiver;Process;Provider;Psyche structure;psychological distress;psychosocial;psychosocial adjustment;Qualitative Research;Quality of life;racial minority;Recommendation;recruit;Registries;Religiosity;Research;Research Design;Risk;rural dwellers;Sampling;skills;social;Social support;socioeconomics;Spirituality;Spouse Caregiver;Stress;Surveillance Program;Survivors;survivorship;Time;Training;training opportunity;Underserved Population;Uninsured;United States;Universities;Well in self;Work;young adult

PROJECT_TITLE: Assessment of social needs and survivorship care experiences among adolescent and young adult (AYA) cancer survivors, families, and the healthcare team


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The COVID-19 pandemic has disrupted multiple aspects of youth's life and poses major risk for their mental health. Data is needed on factors that contribute to risk and resilience mental health trajectories during and following the pandemic. We will investigate a large US youth cohort followed before and during the pandemic to better understand what drives variability of mental health trajectories in US adolescents living through the COVID-19 pandemic.

PI_NAMEs: BARZILAY, RAN  (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: 13 year old;Address;Adolescence;Adolescent;Age;Anxiety;Back;Black race;Brain;child depression;childhood anxiety;Chronic;Chronic stress;Clinical;clinical phenotype;cognitive development;cohort;comparison group;County;COVID-19;COVID-19 pandemic;COVID-19 sequelae;Data;Data Analyses;deprivation;Development;Dimensions;Early Intervention;emotion regulation;Emotional;Environment;Environmental Exposure;Environmental Risk Factor;experience;Exposure to;Financial Hardship;Fostering;Future;Genes;Genetic;genetic information;Genotype;Global Warming;Goals;Growth;Health;Height;Household;improved;Individual;inter-individual variation;Intervention;Life;Longitudinal Studies;male;Measures;Mental Depression;Mental disorders;Mental Health;Modeling;Neighborhoods;Neurocognitive;Outcome;pandemic disease;pandemic stress;pandemic stressor;Participant;Pattern;peer;Persons;Phenotype;Post-Traumatic Stress Disorders;pre-pandemic;preventive intervention;Preventive measure;Process;promote resilience;prospective;Psychiatry;psychologic;Psychopathology;recruit;Research;resilience;resilience factor;response;Risk;Risk Factors;Risk Marker;risk stratification;Sampling Studies;SARS-CoV-2 infection;Schools;sex;Social Interaction;Source;Stress;stress related disorder;stressor;structural determinants;substance use;suicidal behavior;Symptom Burden;Symptoms;System;Teenagers;Time;trait;Trauma;young adult;Youth

PROJECT_TITLE: Prospective predictors of risk and resilience trajectories of mental health in US youth during COVID-19

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Patient Safety

ORG_CITY: NEW YORK

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Coronary artery disease is a leading cause of morbidity and mortality often treated by coronary artery bypass grafting surgery (CABG). CABG surgery is commonly performed via either single arterial graft or multiple arterial grafting strategies - while arterial grafts have better long-term patency than venous grafts, patients receiving multiple arterial grafts may experience higher perioperative risk. This re-submission K23 proposal aims to understand the effect of the two different revascularization strategies (single arterial grafting vs. multiple arterial grafting) on cardiac function immediately after CABG and subsequent clinical outcomes, with the goal of physiologically guided perioperative decision-making and improved clinical outcomes for patients undergoing CABG.

PI_NAMEs: RONG, LISA QIA (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Anesthesia procedures;Anesthetics;Biometry;Blood flow;Cardiac;cardiovascular imaging;career;Clinical;Clinical Research;contrast enhanced;Coronary;Coronary Arteriosclerosis;Coronary Artery Bypass;coronary perfusion;Data;data acquisition;Decision Making;design;Echocardiography;evidence base;experience;Face;Flowmeters;follow-up;Fostering;Funding;Goals;Grant;heart function;heart imaging;hemodynamics;Hour;Image;imaging modality;improved;indexing;insight;International;Intervention;Left;Left Ventricular Ejection Fraction;Left Ventricular Function;Legal patent;Length of Stay;Link;Low Cardiac Output Syndrome;Measurement;Mentorship;Methodology;Methods;Monitor;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardial perfusion;Myocardial Revascularization;New York City;novel imaging technique;operation;Operative Surgical Procedures;Outcome;Outcomes Research;Parents;Patient-Focused Outcomes;Patients;Performance;Perfusion;Perioperative;Pharmaceutical Preparations;pharmacologic;Physiological;Physiology;Postoperative Period;predict clinical outcome;Prognosis;prospective;Randomized;randomized, clinical trials;Recovery;Representational Oligonucleotide Microarray Analysis;Research;Research Personnel;Resistance;response;revascularization;revascularization surgery;Risk;Saphenous Vein;Site;skills;stem;Stress;Surgeon;surgery outcome;Technical Expertise;Techniques;Testing;Training;Transesophageal Echocardiography;Translating;Translational Research;United States;Vasoconstrictor Agents;Vasodilator Agents;Vein graft;Venous;Ventricular;Writing

PROJECT_TITLE: Impact of surgical revascularization strategy on left ventricular function, myocardial perfusion and clinical outcomes

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_DEPT: PEDIATRICS

PHR: This proposal is relevant to public health as it addresses nutritional gaps in one of our most vulnerable populations, preterm infants. The proposal is aligned with the recently released NIH strategic plan to accelerate nutrition research over the next decade and responds to the Notice of Special Interest: Nutrigenetics and Nutrigenomics Approaches for Nutrition Research. Specifically, our research team will conduct a randomized clinical trial of a nutritional fatty acid supplement to inform mechanisms of action and strategies to adequately provide these bioactive nutrients that are critical for fetal and neonatal development..

PI_NAMEs: MARTIN, CAMILIA R (contact);TAYLOR, SARAH N

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acceleration;Address;Age;animal data;Arachidonic Acids;Bioinformatics;Biological;Biological Markers;Biological Process;Biology;Biometry;Birth;Brain;Bronchopulmonary Dysplasia;circulating biomarkers;Clinical;clinical translation;Critical Illness;Data;Derivation procedure;Development;Diet;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;efficacy clinical trial;Enteral;evidence base;Evidence based practice;extreme prematurity;Extremely low gestational age newborn;Eye Development;Failure;fatty acid metabolism;fatty acid supplementation;Fatty Acids;Fatty Change;fetal;Fetal Development;Future;Genes;Growth;Health;Health Benefit;human data;Incidence;Infant;Inflammatory;inflammatory marker;interest;Intravenous;lipid metabolism;lipidomics;Lipids;long chain fatty acid;Lung Diseases;lung injury;Mediator;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Molecular;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Neonatology;Neurocognitive;Nutrient;nutrition;nutrition related genetics;Nutritional;nutritional genomics;Nutritional status;Nutritional Study;Organ;organ growth;Outcome;Pathway interactions;perinatal medicine;pleiotropism;Polyunsaturated Fatty Acids;Population;postnatal;postnatal period;pre-clinical;Pregnancy;Premature Birth;Premature Infant;prevent;Prevention;Printing;Production;Public Health;randomized, clinical trials;Recommendation;Reporting;Research;response;Role;Specificity;Steroids;Strategic Planning;Supplementation;System;Translating;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Metabolic mechanisms induced by enteral DHA and ARA supplementation in preterm infants

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: The education and training of young MD and PhD researchers is the lifeblood of continued progress in medical care. This training grant fills a critical need by preparing these individuals to work at the cutting edge of translational biomedical research in gastrointestinal and liver diseases. The training program focuses on mentoring, career development and advanced degrees in the methods of epidemiology and health services research applied to digestive disorders.

PI_NAMEs: EL-SERAG, HASHEM B;KANWAL, FASIHA  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Research Training

PROJECT_TITLE: Research Training in Gastroenterology


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research will provide important insights into broader population trends in ADRD prevalence and racial disparities in ADRD by considering how education operates differently to reduce risk for cognitive impairment and dementia under more (or less) advantaged educational contexts. The proposed research is relevant to several NIA priorities in the area of Alzheimer’s Disease and related dementias (ADRD), including identifying early life risk and protective factors for ADRD and the linkage of administrative data to existing longitudinal cohort studies.

PI_NAMEs: WALSEMANN, KATRINA  (contact)

PROJECT_TERMS: Address;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Attention;Behavior;Behavioral;Birth;Black race;Brain Injuries;cognitive reserve;cohort;Communities;court;Data;data resource;Degree Completion;Dementia;demographics;Desegregation;Development;Early identification;Education;Educational Assessment;Educational Status;Event;experience;Funding;Goals;Health;Health and Retirement Study;human capital;human old age (65+);Impaired cognition;Incidence;Individual;Inequity;insight;Length;Life;Life Cycle Stages;Link;Local Government;Longitudinal cohort study;Longitudinal Studies;Marriage;Measures;neglect;Occupational;Occupations;older adult;Outcome Study;Pathway interactions;Population trends;Prevalence;protective factors;Public Health;Pupil;Race;racial disparity;Research;Risk;Risk Factors;Risk Reduction;Schools;Scientific Advances and Accomplishments;segregation;Shapes;social determinants;State Government;Students;Subgroup;teacher;Time;trend;user-friendly;Variant;Wages

PROJECT_TITLE: State and Local Educational Contexts of Older U.S. Adults and Their Association with Cognitive Impairment and Dementia

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Genetics

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE These studies will lead to fundamental new insights into the mechanism by which AIF regulates OXPHOS assembly in muscles. In addition, these studies have the potential to identify novel regulators of OXPHOS assembly that interact with AIF to regulate muscle bioenergetics. This may open up therapeutic opportunities for muscle diseases linked to mutations in AIF.

PI_NAMEs: MARKS, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Accounting;Address;Adhesions;Animals;apoptosis inducing factor;Apoptosis Regulation Gene;Apoptotic;Behavioral;Bioenergetics;Biogenesis;Biological Assay;Body Weight;Cell Death;Cellular biology;Chest;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Crista ampullaris;Defect;Down-Regulation;Drosophila genus;Drosophila inturned protein;Drug Metabolic Detoxication;Electrons;experimental study;Functional disorder;Gel;Generations;Genes;Genetic;genetic analysis;Human;Immunoblot Analysis;Inhibition of Apoptosis;Insecta;insight;knock-down;Leg;life span;Link;Measurement;Mediating;Mitochondria;Mitochondrial Diseases;Mitochondrial Proteins;model organism;Molecular Chaperones;Muscle;Muscle Contraction;Muscular Atrophy;Mutation;myogenesis;Myopathy;Nature;novel;novel therapeutics;Nuclear;Organ;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Regulation;Oxidative Stress Induction;Oxidoreductase;Pathogenicity;Pathologic;Peptide Hydrolases;Phenotype;Physiology;Polyacrylamide Gel Electrophoresis;Process;Property;Proteins;Proteomics;proteostasis;Reactive Oxygen Species;Reiterated Genes;Research;Resolution;respiratory;response;RNA Interference;Role;Signal Transduction;Site;skeletal;Skeletal Muscle;Sorting;System;Testing;Therapeutic;therapeutic development;Time;tool;transcriptome sequencing;Transgenic Organisms;Transmission Electron Microscopy;transmission process;Variant;Western Blotting

PROJECT_TITLE: Regulation of OXPHOS Assembly in Skeletal Muscles

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Innate Lymphoid Cells (ILC) are recently described immune effector cells that play key roles in protective immune responses against nearly all classes of pathogens and in tissue homeostasis; but at the same time, their dysregulation contributes to the development of prevalent pathologies such as cancer, asthma, colitis, and obesity. While the transcription factor networks that control ILC development and functions have been extensively studied, how the epigenetic landscape and the 3-dimensional (3D) genome architecture regulate these processes remains largely unknown. In this proposal, we aim to establish how the 3D genomic and epigenetic architecture regulate the development and functions of ILC2 and ILC3 and how specific features of the 3D and epigenetic landscape in ILC2 contribute to allergic airway inflammation.

PI_NAMEs: HENAO-MEJIA, JORGE  (contact);VAHEDI, GOLNAZ

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 3-Dimensional;Ablation;Address;Allergens;Allergic;allergic airway inflammation;Allergic inflammation;allergic response;Architecture;Asthma;Atlases;Binding;Bone Marrow;CD4 Positive T Lymphocytes;Cell Lineage;Cell Maintenance;Chromatin;chromosome conformation capture;Colitis;Data;Data Set;Defect;Development;Disease;Distal;DNA;Effector Cell;Enhancers;Epigenetic Process;Fetal Liver;Genetic;Genetic Transcription;Genome;Genomic Segment;Genomics;Goals;histone modification;Homeostasis;Host Defense;Human;Immune;Immune response;Immune system;Inflammatory;Innate Immune System;Lung;Lymphoid Cell;Malignant Neoplasms;Metabolic;mouse genetics;mouse model;Mouse Strains;Mus;Names;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Obesity;pathogen;Pathology;Play;Population;Process;promoter;Regulation;Regulatory Element;Role;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Specificity;stem cells;Technology;Testing;Time;tissue repair;Tissues;tool;transcription factor;Transcription Repressor;Untranslated RNA

PROJECT_TITLE: 3-Dimensional genomic architecture in innate lymphoid cells and allergic inflammation

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative The microtubule cytoskeleton comprises the tracks for long-range transport in neurons and is essential for long-term health of these cells. Recent in vivo imaging experiments have generated understanding of the biophysical mechanisms that drive microtubule network development, but as of yet, there is no comprehensive theory that can explain microtubule reorganization that occurs in response to injury. This proposal combines novel mathematical modeling with theory-driven experiments in order to synthesize a deeper understanding of neuronal microtubule organization in healthy and injured cells.

PI_NAMEs: CIOCANEL, MARIA-VERONICA ;MCKINLEY, SCOTT A;ROLLS, MELISSA  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Address;Architecture;Axon;axon injury;axon regeneration;Behavior;Biological Assay;Biophysical Process;cell injury;Cells;Coupling;Cytoskeletal Modeling;Cytoskeleton;Dendrites;Development;Differential Equation;discrete time;Drosophila genus;Equilibrium;Excision;experimental study;Filament;flexibility;Foundations;Generations;Genetic;Geometry;Growth;Health;Image;in silico;in vivo;in vivo evaluation;in vivo imaging;in vivo Model;Individual;Injury;insight;Markov Chains;mathematical methods;mathematical model;Mathematics;Measurable;Measurement;Measures;Microtubules;Modeling;Natural regeneration;Neuronal Injury;Neurons;novel;Outcome;Pattern;predictive modeling;Regulation;resilience;response;response to injury;Role;Selection Bias;Shapes;Stereotyping;System;Testing;theories;Time;Validation;Work

PROJECT_TITLE: Pairing Modeling and Experiment to Understand Microtubule Behavior in Healthy and Injured Neurons

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE The proposed study seeks to examine upstream indicators of structural racism as contributors to inequities in receipt of guideline-concordant cervical cancer treatment and survival in a diverse population-based study. Guided by the NIMHD research framework and socio-structural models, this mixed-methods study will leverage two NCI population-based Surveillance, Epidemiology, and End Results Program registries (New Jersey State Cancer Registry and Los Angeles Cancer Surveillance Program), to prospectively examine the impact of micro- mezzo-, and macro-level factors, with an emphasis on health system-level factors, on receipt of guideline concordant treatment for and survival from cervical cancer. Successful accomplishment of the proposed aims will result in high impact findings on the multilevel causes of suboptimal cervical cancer treatment and poorer survival outcomes among marginalized groups to develop actionable system-level practice and policy change to address the persistent cervical cancer inequities.

PI_NAMEs: LLANOS, ADANA A. M. (contact);TSUI, JENNIFER

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: access disparities;Accreditation;Address;Advocate;Age;Area;cancer care;cancer survival;cancer therapy;care delivery;Caring;Cervical Cancer Screening;Characteristics;Clinic;cohort;Communities;Continuity of Patient Care;cultural competence;Data;Data Collection;Data Set;deprivation;Development;Diagnosis;Discrimination;Disease;Early Diagnosis;Economics;Equity;ethnic minority;Ethnic Origin;follow-up;food insecurity;Guidelines;Gynecologic Oncology;health care delivery;health care disparity;Health care facility;Health Disparities Research;health illiteracy;health literacy;Health system;Healthcare Systems;Housing;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immigrant;implementation research;improved outcome;Incidence;Individual;Inequity;Insurance Coverage;Intervention;Interview;Knowledge;Linguistics;Logic;Los Angeles;Low income;low socioeconomic status;Malignant neoplasm of cervix uteri;Malignant Neoplasms;marginalization;marginalized population;Measures;Medical Records;Methods;Modeling;mortality;multi-ethnic;multimodal data;National Cancer Institute;National Institute on Minority Health and Health Disparities;neoplasm registry;New Jersey;optimal treatments;Outcome;Patient Self-Report;Patients;Police;Policies;population based;Population Heterogeneity;Population Study;Poverty;Predictive Factor;prospective;Provider;Quality of Care;Questionnaires;Race;racial minority;Records;recruit;Registries;Research;residence;residential segregation;Risk;Sampling Studies;screening;Screening Result;SEER Program;social;social factors;social structure;Socioeconomic Status;Specialist;structural determinants;Structural Models;Structural Racism;Surveillance Program;survival outcome;survivorship;System;Testing;Translating;Underinsured;Uninsured;United States;Violence;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Assessing Cervical Cancer Healthcare Inequities in Diverse Populations: The ACHIEVE Study

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cardiovascular;Genetics;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: PROJECT NARRATIVE The underlying mechanisms of tyrosine kinase inhibitor-induced vascular toxicity (TKI-VT), an increasingly reported adverse cardiovascular outcome in cancer survivors, are elusive, and preventative or protective treatments are not currently available. Combining patient-specific pluripotent stem cell technology, CRISPR- based high throughput drug screens, physiologically-relevant engineered vascular tissues, and animal models, this proposal seeks to investigate the underlying mechanisms of TKI-VT, which will set the foundation for a more precise search for novel personalized therapeutics for patients manifesting TKI-VT. This proposal will also advance basic and translational research in cardio-oncology by providing a humanized disease modeling and drug discovery platform to study cancer therapy-induced vascular dysfunction in general.

PI_NAMEs: SHEN, MENGCHENG  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: 3-Dimensional;Address;Advisory Committees;Agonist;Angiogenesis Inhibitors;Animal Model;antagonist;Apoptosis;Basic Science;Biological Markers;Biological Models;Biology;Biomedical Engineering;blood perfusion;Blood Vessels;Cancer Patient;Cancer Survivor;cancer therapy;Candidate Disease Gene;Cardiac;Cardiovascular Diseases;Cardiovascular system;career;career development;Cell Communication;Cell Death Induction;Cell Survival;cell type;Clinic;clinical translation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;comparison group;Coronary;Coronary Vessel Anomalies;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;CXCL10 gene;cytotoxicity;Databases;Development;differential expression;Disease;disease model;drug discovery;druggable target;efficacy evaluation;efficacy validation;Endothelial Cells;endothelial stem cell;Endothelium;engineered stem cells;experience;FDA approved;FLT4 gene;Foundations;Functional disorder;Genes;Goals;Harvest;Heart Diseases;Heart failure;high-throughput drug screening;Human;human disease;improved;Individual;induced pluripotent stem cell;Inflammation;inhibitor;innovation;insight;K-Series Research Career Programs;knock-down;Knowledge;Lead;Libraries;Life;Malignant Neoplasms;Measures;Mentors;Mentorship;Molecular;mouse model;multidisciplinary;Myocardial dysfunction;novel;novel therapeutics;Oncology;Outcome;overexpression;Oxidative Stress;Pathogenicity;Patients;Pericytes;Permeability;personalized cancer therapy;personalized therapeutic;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Plasma;Pluripotent Stem Cells;Positioning Attribute;Predisposition;prevent;Proteins;Proteome;Puromycin;Receptor Protein-Tyrosine Kinases;Reporting;Research;research and development;Research Personnel;skills;STAT3 gene;stem cell biology;stem cell technology;Structure;System;Testing;therapeutic candidate;thrombogenesis;Time;Tissue Model;Tissues;Toxic effect;TP53 gene;Training;transcriptome;Translational Research;Triage;Trypsin Inhibitors;tumor;Tyrosine Kinase Inhibitor;Validation;Vascular Diseases;vascular tissue engineering;virtual;Whole Blood

PROJECT_TITLE: Elucidating anti-angiogenic tyrosine kinase inhibitor-induced vascular dysfunction

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: The work described in this proposal seeks to identify molecular mechanisms in the vertebrate retina that the govern the inflammatory response to the injury and death of photoreceptors. This work utilizes zebrafish as an animal model. This project is relevant to the NEI’s mission, because it will create fundamental knowledge regarding mechanisms that govern the regeneration of photoreceptors from cells that are intrinsic to the retina.

PI_NAMEs: HITCHCOCK, PETER F (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;age-related disease;Animal Model;Bioinformatics;Blindness;Cause of Death;Cell Cycle Kinetics;Cell Death;Cell Physiology;cell type;Cells;Cessation of life;cold blooded vertebrate;Data;design;differential expression;Disease;driving force;Foundations;Future;Genes;Genetic Transcription;Goals;Human;Inflammation;Inflammatory;inflammatory milieu;Inflammatory Response;Injury;insight;Knowledge;Mediating;Mediator;Microglia;migration;Mission;Modeling;Molecular;Motivation;Muller's cell;Mutation;Natural Immunity;Natural regeneration;nerve stem cell;Nervous System;neural circuit;neuron regeneration;Neurons;novel;Outcome;Pathway interactions;Photoreceptors;Physiology;Play;Population;progenitor;programs;Proliferating;regenerative biology;repaired;Research;response;response to injury;Retina;Retinal Cone;retinal neuron;Retinal Photoreceptors;retinal regeneration;Role;Site;Source;stem;stem cells;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Vision;Work;Zebrafish

PROJECT_TITLE: Cells and genes that govern inflammation in the subretinal space

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Neuropeptides and, importantly, the enzymes that modify their actions, are involved in an impressively large number of brain functions from healing following stroke, to the perception of pain, learning and memory, and mood. The proposed microfluidic device and its method of use will provide quantitative understanding of neuropeptide action in chosen brain regions. The fundamental and quantitative knowledge gained in the proposed research will aid in approaches, such as drug design, to lessen the harm and promote the good that specific peptides in particular brain regions do.

PI_NAMEs: WEBER, STEPHEN G. (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Address;Affective;Amino Acids;Animals;Anoxia;Anterior;awake;Binding;Brain;Brain Chemistry;brain control;Brain region;brain tissue;Cell surface;Cell Surface Proteins;chronic pain;cingulate cortex;Communication;comparison control;Data;Data Analyses;design;Devices;Diabetes Mellitus;Diffusion;Dimensions;Disease;Drug Design;endogenous opioids;Enkephalins;Enzymes;experience;experimental study;extracellular;Extracellular Space;fabrication;flexibility;Goals;Head;healing;Health;Hydrolysis;Image;implantable device;improved;In Vitro;in vivo;inhibitor;Injury;Kidney Diseases;Kinetics;Knowledge;Lasers;Learning;Liquid substance;lithography;Measurement;Measures;Membrane;Memory;Methods;Michigan;Microdialysis;Microfluidic Microchips;Microfluidics;Modeling;Moods;Natural Substance;Neuropeptides;neuropsychiatric disorder;novel;Opioid Receptor;Pain;Pain Disorder;pain perception;peptide analog;Peptides;Perfusion;photopolymerization;Preparation;Process;Publishing;Rattus;Reaction;Reaction Time;receptor;Reproduction;Research;Sampling;Sensory;Signal Transduction;simulation;Source;Stroke;System;Technology;Testing;Tissues;Trauma;two-photon;Writing

PROJECT_TITLE: A novel microfluidic system for studying brain chemistry and application to study of enkephalin-degrading enzymes in pain perception

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed research is relevant to public health because it supports the NIA mission to translate treatments that can extend healthy longevity in model systems to humans. This project seeks to determine dosing regimens of rapamycin and rapamycin analogs that selectively inhibit mTORC1 and safely modify the fundamental biology of aging in humans.

PI_NAMEs: KONOPKA, ADAM R (contact);LAMMING, DUDLEY WILLIAM

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Address;Adverse effects;Adverse event;Affect;Age;age effect;age-related disease;Aging;aging related;Biological Assay;Biological Models;Biology of Aging;Blood;Blood Chemical Analysis;CCI-779;cellular targeting;Clinic;Clinical Research;Complex;Data;Diet;dosage;Dose;Dose Limiting;Elderly;extend lifespan;FRAP1 gene;Gene Expression;Genetic Transcription;geroprotection;glucose tolerance;Goals;healthspan;healthy aging;Hematology;Human;Immunoprecipitation;Immunosuppression;influenza virus vaccine;inhibitor;insight;Knowledge;Label;life span;lipidomics;Lipids;Longevity;Measures;member;Metabolic;metabolomics;Methodology;Methods;Mission;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;mTOR inhibition;mTOR Inhibitor;mTOR protein;Mus;Muscle;novel;novel strategies;Observational Study;older adult;older men;older women;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacodynamic model;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;phase II trial;Physicians;Physiological;Placebos;Population;prevent;prophylactic;Protein Kinase;Public Health;randomized placebo controlled trial;randomized, clinical trials;Recommendation;Regimen;Research;Risk;Safety;Schedule;Scheme;SDZ RAD;sex;side effect;Signal Transduction;Sirolimus;Specific qualifier value;Specificity;Study Subject;Supervision;Techniques;Testing;Therapeutic;Tissues;Toxic effect;transcriptomics;Translating;United States;vaccine efficacy;Viral Genes;Western Blotting

PROJECT_TITLE: Safer mTOR inhibition for human geroprotection


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Through this multi-center AIP project, we will develop a robust deep learning-based software solution and integrate into the clinical PACS system to convert any clinical PET image into a high-quality counterpart with much lower image noise levels that can only be obtained with >90min long scan or extremely long field-of-view scanners. The translation into PACS servers with “one-button” convenient workflow will lead to fast clinical adoption and substantially benefit clinical practice to improve diagnostic accuracy and increase decision confidence.

PI_NAMEs: BADAWI, RAMSEY D.;EL FAKHRI, GEORGES ;LIN, MINGDE ;LIU, CHI  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Adoption;artificial intelligence algorithm;Bilateral;California;Clinic;Clinical;Clinical Data;clinical decision-making;clinical imaging;Clinical Investigator;clinical practice;Computer software;Data;Data Set;deep learning;deep learning model;Diagnosis;Diagnostic;diagnostic accuracy;Dose;Environment;Evaluation;experience;Feedback;Generations;Healthcare;Human;Hybrids;Image;imaging modality;improved;industry partner;Injections;Investigation;Label;learning network;Lesion;Liver;Mathematics;Modeling;Noise;Organ;Patients;Performance;Physicians;Positron-Emission Tomography;Procedures;Production;Provider;real world application;reconstruction;Research;Research Personnel;Scanning;Services;Site;Structure;System;Techniques;Testing;Time;Training;training data;Translating;Translations;University Hospitals;Validation;Vendor;virtual;virtual model;Visual;X-Ray Computed Tomography

PROJECT_TITLE: Multi-Center Academic-Industrial Partnership for Personalized Al-Enabled High Count PET

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Services;Nutrition;Obesity;Patient Safety;Prevention;Primary Health Care

ORG_CITY: Bloomington

ORG_NAME: HEALTHPARTNERS INSTITUTE

ORG_STATE: MN

PHR: Project Narrative Despite steady increases in obesity prevalence, the more than 12 million obese U.S. adults with type 2 diabetes (T2DM) and severe obesity encounter a number of barriers to adopting effective surgical and pharmaceutical treatments, including: (a) both patients and primary care clinicians frequently underestimate the effectiveness and potential benefits of obesity treatments; and (b) both patients and clinicians typically lack access to evidence-based estimates of the patient-specific potential benefits and risks of appropriate obesity treatment options. This project addresses these important obstacles to evidence-based obesity care by providing accurate, patient-specific estimates of benefits and risks of various obesity treatment options to inform shared decision making about obesity treatment. In this project we implement a scalable, web-based point-of-care decision-support intervention in primary care that provides patient-specific estimates of obesity treatment benefits and risks in a randomized trial in 40 primary care clinics with 15,814 eligible patients, and assess intervention impact on (i) appropriate active management of obesity in eligible patients, (ii) weight trajectories, and (iii) patient and clinician satisfaction with the decision support intervention.

PI_NAMEs: O'CONNOR, PATRICK J (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Adopted;Adult;adult obesity;Affect;Age;American;Arthritis;bariatric surgery;Behavior Therapy;Benefits and Risks;blood glucose regulation;Body mass index;Body Weight decreased;care delivery;Caring;Clinic;Clinical;clinical care;clinical decision support;Clinical Decision Support Systems;clinical encounter;Cluster randomized trial;Communication;Data Reporting;Decision Support Model;design;diabetes management;Diabetes Mellitus;Disease;effective therapy;Effectiveness;Electronic Health Record;electronic medical record system;Eligibility Determination;Equation;Evaluation;evidence base;FDA approved;Health;Health Information System;high risk;Hypertension;improved;indexing;innovation;Intervention;Investments;Life Style;lifestyle intervention;Link;Metabolic;Morbid Obesity;Myocardial Infarction;neglect;Non-Insulin-Dependent Diabetes Mellitus;obese patients;Obesity;obesity management;obesity treatment;Online Systems;Operative Surgical Procedures;Outcome;Outpatients;Patient Care;patient oriented;Patients;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacotherapy;point of care;predictive modeling;Prevalence;Primary Care;primary care clinic;primary care clinician;primary outcome;Privatization;Randomized;randomized trial;Regimen;Reporting;Sampling;satisfaction;sex;shared decision making;Sleep Apnea Syndromes;Stroke;Suggestion;Surveys;Time;Translating;treatment as usual;Update;Visit;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Reducing Clinical Inertia in Obesity Management of Diabetes in Primary Care: Cluster-Randomized Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative: Substance use disorders (SUDs) remain a significant public health problem that requires more effective treatment interventions. A cadre of clinical researchers is needed to develop novel treatment interventions for SUDs, often through translational research, to better understand who best responds to these interventions, and ways to best promote the implementation of these interventions. Our long- standing program has been at the forefront of training early career investigators and through continued support, our program hopes to continue to train the next generation of clinical investigators who will eventually become leaders in the substance use disorder field.

PI_NAMEs: LEVIN, FRANCES RUDNICK (contact);MARTINEZ, DIANA M

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Clinical Research;clinical translation;Fellowship;Substance Use Disorder

PROJECT_TITLE: Translational Clinical Research Fellowship on Substance Use Disorders

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-S-K]


PHR: PROJECT NARRATIVE Obesity and asthma are common health conditions in the United States, and obesity-associated asthma tends to be more severe and difficult to control compared to other phenotypes of asthma. Understanding why this may be is important in reducing symptoms and disability associated with this common phenotype of asthma. This proposal examines if insulin resistance, pre-diabetes, and diabetes are associated with asthma outcomes, and if this association is stronger in obesity, in the hopes of identifying a new treatment target for obesity- associated asthma.

PI_NAMEs: WU, TIANSHI DAVID (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Asthma;asthma exacerbation;bariatric surgery;Big Data;Biometry;Blood Glucose;Body mass index;career;career development;Clinical;Clinical Data;clinical phenotype;Clinical Research;cohort;Cohort Analysis;Cohort Studies;comparison control;Critical Care;Data;Data Collection;design;Development;Development Plans;Diabetes Mellitus;disability;Disease;disorder control;Electronic Health Record;Enrollment;Environment;Epidemiologist;Epidemiology;epidemiology study;evidence base;Experimental Designs;Faculty;Fasting;Fellowship;General Population;glucose metabolism;glycemic control;Glycosylated hemoglobin A;Goals;Health;Health system;high body mass index;Human;Human Subject Research;improved;Individual;innovation;insight;Insulin Resistance;Investigation;Knowledge;Level of Evidence;Literature;Longitudinal Studies;Lung;lung health;Measurement;Measures;Medicine;Mentors;Mentorship;Metformin;Methodology;modifiable risk;Modification;Morbidity - disease rate;Natural experiment;novel;obese person;Obesity;obesity risk;obesity-associated asthma;Observational Study;Outcome;Participant;Pathologic;Pathway interactions;patient oriented;patient oriented research;Patients;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;Phenotype;Physicians;Pliability;Population;Postoperative Period;Prediabetes syndrome;Productivity;prospective;Prospective cohort;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Questionnaires;Recording of previous events;reduce symptoms;Reporting;Research;Research Activity;Research Proposals;research study;Respiratory Signs and Symptoms;Risk;Risk Factors;Role;Scientist;Severities;Severity of illness;skills;Spirometry;Sulfonylurea Compounds;Techniques;Testing;Time;Training;Translating;United States;Universities

PROJECT_TITLE: Insulin Resistance, Pre-Diabetes, and Diabetes in Obesity-Associated Asthma

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: LOUISVILLE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE Humans have developed mechanisms to restrict bacterial access to metals during infection, and thus, pathogens in turn have evolved high-affinity metal acquisition systems to overcome this restriction. This project will identify the mechanisms used by Yersinia pestis to acquire zinc in order to cause the human disease plague. As metal acquisition is essential for virulence, defining these mechanisms will reveal novel targets for the development of new anti-plague therapeutics.

PI_NAMEs: LAWRENZ, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: 3-Dimensional;Affinity;Attenuated;Bacteria;Binding;Bubonic Plague;Cells;Characteristics;Chemicals;combat;Crystallography;Data;Defect;Development;Drug Targeting;efflux pump;fitness;Foundations;Goals;Gram-Negative Bacteria;Hemochromatosis;Human;human disease;Immune response;improved;In Vitro;Infection;inhibitor;innovation;Iron;Kinetics;Lead;Leukocyte L1 Antigen Complex;Leukocytes;Mammals;Mediating;Membrane;Metals;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;neutrophil;novel;novel therapeutic intervention;novel therapeutics;Nutritional Immunity;pathogen;pathogenic bacteria;permease;Plague;Pneumonic Plague;Predisposition;Prevention;Proteins;Pump;rational design;receptor;Research Personnel;response;Role;Siderophores;Solid;Specificity;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;Time;transposon sequencing;Virulence;Virulence Factors;Work;Yersinia pestis;yersiniabactin;Zinc

PROJECT_TITLE: Iron independent role for yersiniabactin in Yersinia pestis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE This application aims to establish a new universal serum biomarker for germ cell tumors, the most common solid tumor of adolescents and young adults. The proposed serum miRNA panel will be used to more accurately predict and diagnose relapse.

PI_NAMEs: FRAZIER, ANNE LINDSAY (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Adjuvant Chemotherapy;Adolescent and Young Adult;Adult;Age;Biological Assay;Biological Markers;Canada;cancer imaging;Categories;chemotherapy;Childhood;circulating microRNA;Clinical;clinical care;Clinical Sensitivity;Clinical Trials;Data;Decision Making;Diagnosis;Disease;Early Diagnosis;Eligibility Determination;Enrollment;Excision;experimental study;Gender;Germ Cell Cancers;Germ cell tumor;Goals;Grant;hazard;Health Care Costs;Histology;Human Chorionic Gonadotropin;Image;Individual;Institution;Laboratories;Malignant - descriptor;Malignant Neoplasms;Medical;Methodology;microRNA biomarkers;MicroRNAs;Monitor;Normal Range;Operative Surgical Procedures;Outcome;Patient Selection;Patients;Pediatric Oncology Group;Phase;Postoperative Period;Predictive Value;Predictive Value of Tests;Prevalence;Primary Neoplasm;Procedures;Process;prospective;quality assurance;Radiation exposure;Rationalization;Recommendation;Recurrence;Reference Values;Relapse;relapse patients;Research;Resected;Reverse Transcription;Sensitivity and Specificity;Serum;sex;Site;Solid Neoplasm;Specificity;Staging;standard of care;surveillance imaging;Technology;Testing;Time;Tumor Markers;United Kingdom;United States;Validation;X-Ray Computed Tomography;α-Fetoproteins

PROJECT_TITLE: Assay Validation of a Circulating miRNA Test for Diagnosis and Monitoring of Malignant Germ Cell Tumors