ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Childhood Injury;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: Newborn brain injury is one of the most significant causes of impaired outcomes in American children, but the impacts of both excessively high and low blood sugar is surprisingly poorly understood. Using an innovative method to monitor blood glucose levels continuously, it has been discovered that more than half of newborns with encephalopathy have high blood sugar, which independently is associated with abnormalities in immediate brain function and brain injury. Understanding how specific levels of low and high glucose in the early neonatal period impact on long-term outcomes by school age will not only help with early identification of babies at greatest risk, but also tailor appropriate treatments to improve long-term outcomes in these vulnerable newborns.

PI_NAMEs: TAM, EMILY WING YUN (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 5 year old;Acute;Adult;adverse outcome;Age;Altered Level of Consciousness;American;Behavioral;Blood Glucose;Brain;brain circuitry;brain dysfunction;Brain Hypoxia-Ischemia;Brain Injuries;Breathing;cerebral visual impairment;Child;Clinical;Cognitive;cognitive function;cohort;Continuous Glucose Monitor;Data;Death Rate;design;Diagnosis;disability;Early Diagnosis;Early identification;effective therapy;Encephalopathies;Enrollment;feeding;follow-up;Glucose;Hyperglycemia;Hypoglycemia;Impairment;improved;improved outcome;Incidence;innovation;Intervention;Intervention Trial;Investigation;Knowledge;Language;Link;Literature;Live Birth;Magnetic Resonance Imaging;Magnetoencephalography;Methods;Monitor;Motor;natural hypothermia;neonatal encephalopathy;Neonatal Hypoglycemia;neonatal hypoxic-ischemic brain injury;neonatal period;neonate;Neurodevelopmental Impairment;Neurodevelopmental Problem;Neurologic;Neurological outcome;neuroprotection;Neuropsychological Tests;Neuropsychology;new technology;newborn brain injury;Newborn Infant;Outcome;outcome prediction;Parents;Prospective, cohort study;Questionnaires;Reflex action;Research;Rest;Risk;School-Age Population;Seizures;Severities;social;Standardization;Syndrome;Testing;Therapeutic;Translating;Vision;Visual;Visual Cortex;visual processing

PROJECT_TITLE: Neurological Outcome of Glycemia in Neonatal Encephalopathy

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: BLOOMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Horizontal gene transfer by natural transformation contributes to the rapid spread of antibiotic resistance and virulence factors. Using the cholera pathogen Vibrio cholerae as a model system, we propose to characterize the basic biology and mechanisms of natural transformation in a physiologically relevant environmental context. These studies may inform novel strategies to combat clinically relevant infections and stem the spread of antibiotic resistance and virulence in diverse bacterial pathogens.

PI_NAMEs: DALIA, ANKUR  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Antibiotic Resistance;appendage;Area;ATP phosphohydrolase;Bacteria;Basic Science;Binding;Biological;Biological Models;Biology;Cells;Chitin;Cholera;clinically relevant;combat;Crustacea;Cues;diarrheal disease;DNA;DNA Binding;Environment;Fimbriae Proteins;Genes;Genetic;genetic approach;Horizontal Gene Transfer;Infection;Label;Membrane;membrane activity;microbial;Microbial Biofilms;Minor;Motor;novel strategies;Nutritional;pathogen;Pathogenesis;pathogenic bacteria;Physiological;Pilum;Play;Predatory Behavior;Process;Regulation;Regulon;resistance factors;Role;Signal Transduction;spatiotemporal;stem;Surface;Testing;tool;transcription factor;transmission process;uptake;Vibrio;Vibrio cholerae;Virulence;Virulence Factors;waterborne;Work;Zooplankton

PROJECT_TITLE: Mechanisms and regulation of horizontal gene transfer by natural transformation in Vibrio cholerae

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative The proposed mixed method study leverages the unique strengths of secondary data analyses and qualitative interviews to lay the foundation for a more culturally-competent and clinically useful approach to understand risk and resilience for alcohol use in transgender and gender diverse (TGD) adults. Findings from our study will highlight the dynamic risks, strengths, and needs related to alcohol use that comprehensive clinical protocols should target when working with diverse TGD populations.

PI_NAMEs: COHEN, JOSEPH R;SHOREY, RYAN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Adult;Age;Alcohol abuse;alcohol abuse therapy;alcohol availability;Alcohol consumption;alcohol intervention;alcohol related problem;alcohol risk;alcohol use disorder;Alcohols;Algorithms;Assessment tool;Attention;Child Abuse;cisgender;Classification;Clinical;Clinical Protocols;Communities;cultural competence;Data;Data Analyses;Discrimination;Disparity;drinking;Drug usage;effective intervention;Ensure;ethnic minority;Ethnic Origin;Event;Evidence Based Medicine;experience;Face;Family;Foundations;Future;Gender;gender diverse;Gender Identity;gender minority;gender minority group;General Population;harassment;Health Personnel;Health Services Accessibility;Heavy Drinking;indexing;Individual;innovation;interest;intersectionality;Intervention;Interview;Knowledge;lens;Life;life history;Literature;marginalization;Mental Health;Methodology;Methods;Minority;Minority Health Research;minority stress;minority stressor;Modeling;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;nonbinary;novel;Persons;Phase;Policy Maker;Population;Population Heterogeneity;Poverty;prevent;Prevention Research;Process;Provider;Public Health;Race;racial diversity;racial minority;Recording of previous events;Research;Research Methodology;resilience;resilience factor;response;Risk;Risk Factors;risk prediction;Sampling;Screening procedure;Sex Orientation;sexual minority group;sexual minority health;Shapes;Social status;stressor;Surveys;Testing;theories;timeline;transgender;transgender men;transgender women;Translating;Translations;transphobia;Violence;Vulnerable Populations

PROJECT_TITLE: A Mixed-Method Study on Transgender and Gender Diverse Adults’ Alcohol Use

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Opioid-alcohol polysubstance use is common and is accompanied by worsened health outcomes. There is little to no research characterizing the temporal patterns of such polysubstance use or the neuro-biobehavioral outcomes of polysubstance use. The proposed project will assess temporal patterns of opioid-alcohol polysubstance use in humans and use these data to develop rat models of polysubstance use in order to characterize its biological and cognitive consequences and thus guide development of therapies to ameliorate pathological outcomes.

PI_NAMEs: COTTLER, LINDA B.;KNACKSTEDT, LORI A (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acute;Address;Adopted;Adverse effects;adverse outcome;Affect;alcohol comorbidity;Alcohol consumption;alcohol involvement;Alcohols;Animal Model;Back;Base Sequence;Behavior;Behavioral;biobehavior;Biological;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;community engagement;Consumption;Data;Decision Making;Diagnosis;Disease;Drug Kinetics;drug metabolism;Drug usage;DSM-V;Episodic memory;flexibility;Focus Groups;follow-up;Frequencies;Goals;Health;Hour;Human;human data;Impaired cognition;Impairment;Impulsivity;Individual;Intake;interest;Interview;Knowledge;Long-Term Effects;Longitudinal Studies;meetings;Modeling;Motivation;multidisciplinary;neural circuit;neuroadaptation;neurobehavioral;Neurobiology;Neurocognitive;novel;Opioid;opioid injection;opioid overdose;opioid use;opioid use disorder;opioid user;Oral Administration;Outcome;Oxycodone;Participant;Pathologic;Patient Recruitments;Pattern;Pharmaceutical Preparations;Phase;phase 2 study;polysubstance abuse;polysubstance use;Positioning Attribute;Pre-Clinical Model;programs;Publishing;Rattus;Relapse;Reporting;Research;Research Design;response;Rodent;Rodent Model;Role;Self Administration;Sequence Analysis;Severities;Short-Term Memory;Substance abuse problem;substance use;Testing;Therapeutic;therapy development;Time;Translating;Treatment outcome;trend;Typology;Withdrawal

PROJECT_TITLE: Patterns and neurocognitive consequences of opioid-alcohol polysubstance use

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Biotechnology;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Nutrition;Obesity;Pediatric;Pregnancy;Prevention

ORG_CITY: IRVINE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: The overall goal of this application is to provide Dr. Lauren Gyllenhammer support and protected time for an intensive,  supervised career development experience in the biomedical, and developmental sciences, leading to research independence. Based on a rigorous research question and methodology she has developed, Dr. Gyllenhammer will conduct  trans-disciplinary research to investigate the potential for maternal prenatal stress to potentiate the effects of maternal  insulin resistance on the development of offspring adiposity and mitochondrial health. This application describes her  academic background, training activities, research strategy and career development plan.

PI_NAMEs: GYLLENHAMMER, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abdomen;acute stress;Address;Adipose tissue;Advisory Committees;Age;Animals;Area Under Curve;Behavior Therapy;Bioinformatics;Biological;Biological Products;Birth;Body Composition;Body fat;Body mass index;career;career development;Cell Culture Techniques;Cells;Cellular biology;Child;Childhood;Citrate (si)-Synthase;Clinical;cohort;Cross-Over Studies;Crossover Design;Data;design;Development;Development Plans;Developmental Biology;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;Enrollment;Ensure;experience;Exposure to;Fasting;fasting glucose;Fatty acid glycerol esters;fetal;fetal programming;Funding;Gestational Age;Glucose;Goals;Health;Hepatic;Homeostasis;Hormones;Human;Hydrocortisone;Image;improved;in utero;in vivo;indexing;Individual Differences;infancy;Infant;infant adiposity;Instruction;Insulin;Insulin Resistance;Intra-abdominal;Investigation;Knowledge;Late pregnancy;Magnetic Resonance;Magnetic Resonance Imaging;Maternal Age;maternal stress;Measures;Mediating;Mediator;Mentors;Metabolic;Metabolic dysfunction;Metabolic stress;Methodology;Methods;Mitochondria;Mitochondrial DNA;Modeling;Mothers;Newborn Infant;novel;Nuclear;Obesity;obesity in children;obesity risk;Observational Study;offspring;OGTT;Outcome;Pathogenesis;Peripheral Blood Mononuclear Cell;Phase;Physiological;Physiology;population based;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;prenatal stress;prepregnancy;Prevention;Production;prospective;Psychological Stress;Public Health;Randomized;Research;Research Design;Research Personnel;Respiratory Chain;response;Risk Factors;Role;Salivary;Science;sex;Shapes;Standardization;Statistical Models;Stratification;Stress;stress reduction;subcutaneous;symposium;Techniques;Testing;Time;Training;Training Activity;Treatment Efficacy;Trier Social Stress Test;Umbilical Cord Blood;United States National Institutes of Health;Weight

PROJECT_TITLE: Synergistic effect of maternal insulin-resistance and cortisol in pregnancy on fetal programming of child mitochondrial function and obesity risk


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Allergic diseases afflict 40% of the United States population, but it is unknown how allergens activate dendritic cells which are required for the initiation of allergic immune responses. A research program will be undertaken to study the neuroimmune interactions that endow sensory neurons with the ability to detect allergens, and how sensory neurons and dendritic cells interact to promote the activation of the allergic immune response. These studies will provide fundamental basic immunological insights into how allergic disease is initiated and will lay the foundation to develop novel therapeutic strategies to prevent and treat allergic diseases.

PI_NAMEs: SOKOL, CAROLINE LAUREN (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: adaptive immune response;Afferent Neurons;Allergens;Allergic;Allergic Disease;Antigens;B-Lymphocytes;Bacteria;Basophils;CCR8 gene;Cell Communication;Cell Maturation;cell motility;Cell Physiology;Cells;Cellular Immunology;Cellular Neurobiology;chronic itch;Cutaneous;Data;Dendritic cell activation;Dendritic Cells;Dermal;Dermis;Detection;Development;Disease;draining lymph node;Endowment;environmental allergen;experience;Foundations;fungus;Gene Modified;Goals;Health;IgE;Immune;immune activation;Immune response;Immune system;Immunity;Immunization;Immunologics;improved;In Vitro;in vivo;Innate Immune Response;Innate Immune System;insight;Interleukin-4;Laboratories;Licensing;Lymphoid Cell;mast cell;migration;Mus;Nervous System;Neuroimmune;Neurons;Neuropeptides;neurotransmitter release;novel;novel therapeutic intervention;novel therapeutics;pain sensation;Papain;Papaya;Pathway interactions;Patients;Peptide Hydrolases;Play;Population;Prevalence;prevent;Production;programs;Pruritus;release factor;Research;response;Role;sensor;Sensory;Signal Transduction;Skin;Substance P;T-Lymphocyte;Testing;Th2 Cells;therapeutic development;tool;TRPV1 gene;United States;Venoms

PROJECT_TITLE: Neuroimmune Control of Allergic Immunity

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

ORG_CITY: OXFORD

ORG_NAME: MIAMI UNIVERSITY OXFORD

ORG_STATE: OH

PHR: Project Narrative A longstanding goal of retinal restoration therapies is to devise methods that enable the replacement of retinal neurons from endogenous cell sources. Embryonic retinal pigment epithelium (RPE) cells have a transitory ability to regenerate retinal neurons, but as RPE cells mature they lose their neural competence. The proposed study will leverage multi-modal data analysis to interrogate the molecular foundations of RPE cell identity, with the intention of recovering the regenerative potential of RPE cells at advanced stages of differentiation.

PI_NAMEs: DEL RIO-TSONIS, KATIA  (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Acute;Address;adult neurogenesis;ATAC-seq;Atlases;Behavior;Binding;Binding Sites;Biological Assay;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chick Embryo;Chicken Cells;Chickens;Chromatin;Chromosome Mapping;Cleavage Under Targets and Release Using Nuclease;Competence;CRISPR/Cas technology;Data Analyses;Data Set;Development;DNA;DNA Binding;DNA mapping;DNA Methylation;DNA Modification Process;Embryo;embryo cell;Epigenetic Process;epithelial stem cell;Event;Eye;FGF2 gene;Foundations;Gene Expression Regulation;Genes;Genetic Markers;Genetic Transcription;Genome Mappings;genome-wide;genome-wide analysis;Goals;histone modification;innovation;insight;Intention;loss of function;Maps;Methodology;Methods;Molecular;Molecular Probes;multimodal data;multimodality;Natural regeneration;Nerve Regeneration;neural;Neural Retina;neuronal replacement;novel;Pattern;permissiveness;Phenotype;programs;Public Health;regeneration potential;Replacement Therapy;Repression;Resolution;response;restoration;Retina;Retinal Degeneration;retinal neuron;retinal regeneration;Role;Series;single nucleus RNA-sequencing;Source;Structure of retinal pigment epithelium;Time;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;Vision

PROJECT_TITLE: A Roadmap to Uncover RPE Plasticity

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_DEPT: SURGERY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This application seeks ongoing funding for our T32 training program, currently in its 24th year of continuous funding. The program provides sophisticated basic/translational, clinical and biomedical engineering training to highly selected Johns Hopkins Surgery Residents pursuing advanced GI surgery.

PI_NAMEs: HACKAM, DAVID J (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Clinical Research;gastrointestinal;Laboratory Research;Research Training;Surgeon

PROJECT_TITLE: Clinical and Laboratory Research Training for Gastrointestinal Surgeons


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Neurosciences;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative As recreational and medical cannabis use becomes more prevalent and the strength of legal market cannabis increases, users and policy makers need timely information on the impact of current strains on cognitive function and if there are forms or potencies that minimize cognitive harm. Our global hypothesis is that the effects of cannabis on memory vary as a function of the ratio of CBD to THC (the two major cannabinoids in cannabis), with THC having adverse effects that can be counteracted by CBD. To that end, we will test the effects of cannabis strains with differing THC and CBD levels on recognition memory performance as well as event-related brain potentials (ERPs) that have previously been found to be related to different underlying memory processes.

PI_NAMEs: BIDWELL, L. CINNAMON;CURRAN, TIMOTHY E (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Acute;Adverse effects;Blood;Brain;Cannabidiol;Cannabinoids;Cannabis;Cannabis retail;Climate;Cognitive;cognitive function;Collection;Data;design;Dissociation;endogenous cannabinoid system;Episodic memory;Event;experimental study;Familiarity;Goals;Harm Reduction;high risk;Impairment;indexing;Intoxication;knowledge base;Learning;Legal;marijuana use;marijuana user;Marketing;Measures;Medical;Medical Marijuana;Medicine;Memory;memory encoding;memory process;memory recognition;memory retrieval;Monitor;Participant;Performance;Pharmacology;Phase;Policies;Policy Maker;Process;Property;Randomized;Recreation;Relative Risks;Research;Retrieval;Risk Assessment;Role;Self Administration;Stimulus;Testing;Tetrahydrocannabinol;Variant;verbal;Work

PROJECT_TITLE: ERP studies of acute influences of THC and CBD on memory encoding and retrieval processes

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Rehabilitation;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Millions of Americans suffer from chronic pain, opioid misuse, and opioid use disorder. New intervention strategies that integrate mindfulness, physical therapy, and/or medications for opioid use disorder (MOUD) are needed to improve health outcomes in these vulnerable patients. To accomplish this aim, we propose the Opioid and Pain Effectiveness research Network for Mindfulness and Integrative Health Intervention Development (OPEN-MIIND), a multidisciplinary research center dedicated to addressing the opioid crisis.

PI_NAMEs: GARLAND, ERIC LEE (contact);ZEIDAN, FADEL

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Address;Adjuvant;Affect;Affective;Aftercare;American;Analgesics;Analysis of Variance;arterial spin labeling;Back;Behavior;Behavioral;behavioral response;Belief;biobehavior;Brain;Breathing;Brief Pain Inventory;central pain;Characteristics;Chronic;Chronic disabling pain;Chronic low back pain;chronic pain;chronic pain management;chronic pain patient;chronic painful condition;Clinical;clinical pain;Clinical Trials;cost effective treatment;Data;Dedications;Distress;Dose;Economic Burden;effective therapy;effectiveness research;Electroencephalography;Evidence based intervention;Expectancy;expectation;follow-up;Functional Magnetic Resonance Imaging;Future;Goals;Group Psychotherapy;Health;improved;Individual;Individual Differences;Informal Social Control;innovation;insight;Integrative Medicine;Interdisciplinary Study;Intervention;Literature;Mediating;medication for opioid use disorder;Meditation;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness meditation;Mindfulness Training;Modeling;Morbidity - disease rate;mortality;negative affect;neural;neuroimaging;neuromechanism;neuropsychopharmacology;Nociception;Nonpharmacologic Therapy;novel;Opioid;Opioid Analgesics;opioid epidemic;opioid misuse;opioid sparing;opioid therapy;opioid use;opioid use disorder;Outcome;Pain;pain patient;pain processing;pain relief;pain symptom;Patients;Persons;Physical therapy;placebo controlled study;Placebo Effect;Placebos;prescription opioid;Process;Psychophysics;Psychotherapy;Public Health;Publishing;randomized, clinical trials;Recovery;Regulation;Research;response;Rest;reward processing;Rewards;Science;Severities;skills;Social support;Techniques;Testing;Thalamic structure;Therapeutic;Therapeutic Effect;therapy development;timeline;Training;Translational Research;treatment as usual;Treatment Efficacy;Work

PROJECT_TITLE: Analgesic and Opioid Sparing Brain Mechanisms of Mindfulness-Oriented Recovery Enhancement for Chronic Low Back Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BATON ROUGE

ORG_DEPT: PATHOLOGY

ORG_NAME: LOUISIANA STATE UNIV A&M COL BATON ROUGE

ORG_STATE: LA

PHR: OVERALL Project Narrative The overall goal of this INBRE renewal application is the facilitation of quality biomedical research activities throughout the State of Louisiana with an emphasis on building research capacity and workforce development. Starting with 2016, overall operations have been re-organized to maximize effectiveness and impact by increased involvement of the PUI Steering Committee members via bi annual retreats written reports, appointment of Core Liaison Officers (CLO) representing each Core, and creation of a “Core Bucks” funding mechanism to support access to Cores for all PUI faculty. In this application, additional major changes are proposed to further improve the currently successful LBRN program, such as: expansion of the number of PUIs from seven to eight by adding the University of New Orleans (UNO) campus; expansion of undergraduate research experiences to include entire academic year, as well as summer experiences in both academic and industrial settings by soliciting additional financial support for the LBRN program from not-for-profit-institutions, as well as from for-profit institutions.

PI_NAMEs: KOUSOULAS, KONSTANTIN G (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: American Association for the Advancement of Science;Appointment;Area;Bioinformatics;Biomedical Research;Biometry;career;Cellular biology;Centers of Research Excellence;Collaborations;Committee Members;Communication;Computational Biology;cyber infrastructure;Development;Disease;Educational workshop;Effectiveness;Ensure;Evaluation;Event;experience;Faculty;Financial Support;Funding;Funding Mechanisms;Goals;Growth;Human Resources Development;improved;Individual;Industrialization;Infrastructure;Institution;interest;Link;Louisiana;Mentors;Mission;Molecular;Monitor;operation;Patient Self-Report;Pilot Projects;Preventive Medicine;Process;Productivity;programs;Publications;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Scientist;structural biology;summer research;support network;symposium;Technology;Therapeutic;Time;Training;training opportunity;undergraduate research experience;undergraduate student;Universities;Veterinary Medicine;Veterinary Schools;Work;Workforce Development;Writing

PROJECT_TITLE: Louisiana Biomedical Research Network (LBRN)


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: Project narrative  The Administrative Core (AC) is central to the leadership and administration of the Louisiana Biomedical  Research network (LBRN). It communicates directly with NIH program staff and is responsible for the overall  organization, management, and assessment of the Developmental Research Project Program (DRPP) and  Undergraduate Research Opportunities. The AC will oversee the cores and their interactions. The AC is led by  the Principal Investigator PI in close collaboration with the Program Coordinator (PC) and is supported by the  Directors of the two Cores Molecular and Cellular Biology Research Core (MCBRC) and the Bioinformatics  Biostatistics and Computational Biology, Core (BBCC), Steering Committee (SC) members from the primarily  undergraduate institutions (PUIs) and three other eminent scientists will assist the PI and PC with the tasks  and decisions necessary to maintain and grow the LBRN. The External Advisory Committee (EAC) will  evaluate all of the component parts of the LBRN and provide a detailed critique, to be discussed with and  acted upon by the AC. Additional assessment of the LBRN will be provided annually by the internal evaluation  team and in year 2 and 4 by an external evaluations team.

PROJECT_TERMS: Advisory Committees;Affect;American Association for the Advancement of Science;Benchmarking;Bioinformatics;Biomedical Research;Biometry;Collaborations;Committee Members;Communication;Communities;Computational Biology;Critiques;Development;Electronic Mail;Enrollment;Evaluation;Evaluation Methodology;Faculty;Funding;Goals;graduate student;Grant;Institution;Leadership;Louisiana;meetings;member;Mentorship;Molecular and Cellular Biology;Monitor;Outcome;Policies;Principal Investigator;Procedures;Program Research Project Grants;programs;Public Relations;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Scientist;Senior Scientist;Students;summer program;summer research;undergraduate research experience;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE People not only form social relationships themselves, but they also form an understanding of the relationships among other people. A lack of such understanding, or inaccuracies in perception, can contribute to social isolation in the elderly or reduce a person’s ability to influence the social world around them. Understanding all this gives us new insights not only into how the human mind works, not only into certain kinds of social isolation, but also into why some people are better able to foster the diffusion of innovative public health ideas and behaviors among their social connections.

PI_NAMEs: CHRISTAKIS, NICHOLAS A (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: 3-Dimensional;Affect;Age;aged;Aging;Behavior;Characteristics;Cognitive;cognitive load;cohort;Data;Data Collection;Data Set;Dementia;Diffusion;Disclosure;Educational Intervention;Elderly;Elements;experience;experimental study;Fostering;Friends;Health;Honduras;Human;Impaired cognition;Individual;innovation;insight;interest;Life Cycle Stages;Longitudinal cohort;male;Maps;Measures;member;mental representation;Methods;Mind;novel;Older Population;Participant;Pattern;peer;Perception;Personal Satisfaction;Persons;Population;Positioning Attribute;Psyche structure;Public Health;Randomized;Reporting;Rural;Schools;sex;social;social cognition;social influence;Social intelligence;Social isolation;Social Network;social neuroscience;Social Perception;social relationships;Social support;Structure;Time;Work

PROJECT_TITLE: Characterizing Individuals' Cognitive Maps of their Village Social Networks

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative BIOINFORMATICS, BIOSTATISTICS, AND COMPUTATIONAL BIOLOGY CORE (BBCC) The LBRN Bioinformatics, Biostatistics and Computational Biology Core (BBCC) is an interdisciplinary core of biostatisticians, modelers, biocomputing scientists, software tool developers and bioinformaticians with expertise in various biomedical related research areas. This core provides training through seminars, workshops, hands-on lab specific training, and direct one-one consultation. Headquartered at the LSU Center for Computation & Technology (CCT), BBCC serves to educate, train and support project investigators and their teams across Louisiana, and to lead and support translational research activities at the frontiers of biomedical science.

PI_NAMEs: TAYLOR, CHRISTOPHER MICHAEL (contact)

PROJECT_TERMS: Applications Grants;Area;biocomputing;Bioinformatics;bioinformatics network;Biomedical Research;Biometry;Categories;Collaborations;Computational Biology;Computer Analysis;Computer software;Computer Systems;computing resources;Consultations;cyber infrastructure;Data Storage and Retrieval;Dedications;Economic Development;Educational workshop;Experimental Designs;Faculty;frontier;Funding;Goals;High Performance Computing;Human Resources;Lead;Leadership;Louisiana;Manuscripts;novel;Preparation;Reporting;Research;Research Activity;research and development;Research Design;Research Personnel;Science;Scientist;Services;Software Tools;Statistical Methods;Students;Technology;tool;Training;Training and Education;Translational Research

PROJECT_TITLE: Bioinformatics, Biostatistics, and Computational Biology Core (BBCC)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative: This proposal is relevant to public health because our goal is to create a viable drug candidate that can improve the treatment of metastatic colorectal cancer, which is currently associated with very high rates of morbidity and mortality. The proposed project has the potential to provide a clinical candidate for enhanced immunotherapy of metastatic colorectal cancer, and this could make the difference in many lives.

PI_NAMEs: LIN, WENBIN ;WEICHSELBAUM, RALPH R (contact)

PROGRAM_OFFICER_NAME: CHRISTEN, JAYNE

PROJECT_TERMS: absorption;Affect;Agonist;anti-cancer;anti-PD-L1;anti-PD-L1 antibodies;anti-PD1 antibodies;anti-tumor immune response;Antigen Presentation;Antigens;Biodistribution;Bioinformatics;biomaterial compatibility;Cancer Etiology;Cancer Model;Cancer Patient;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cells;Cessation of life;checkpoint therapy;Chemicals;Clinical;clinical application;clinical candidate;clinical development;Clinical Research;colon cancer patients;Colorectal Cancer;Combined Modality Therapy;Cross-Priming;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Development;Diagnosis;Dinucleoside Phosphates;Disease;Disseminated Malignant Neoplasm;Distant;DNA;drug candidate;Drug Kinetics;effective therapy;Epithelial Cells;Formulation;Gene Activation;genome sequencing;Goals;Human;Hybrids;hydrophilicity;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune system;immunogenic;Immunologics;Immunomodulators;Immunotherapy;improved;in vivo;individual patient;Injections;insight;Interferon Type I;Interferon-beta;intravenous injection;Ions;Ligands;MC38;Mediating;Melanoma;Memory;Metals;metastatic colorectal;Metastatic Neoplasm to the Liver;Methods;Microsatellite Instability;Microsatellite Repeats;Mismatch Repair;Mismatch Repair Deficiency;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;nanocarrier;nanoparticle;nanoscale;nanotherapeutic;neoantigens;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutics;Organ;particle;patient response;patient subsets;Patients;PD-1/PD-L1;PD-L1 blockade;Peptides;Periodicity;Permeability;Phagocytes;phosphoric diester hydrolase;Plasma Proteins;Polymers;preclinical development;Progression-Free Survivals;Proliferating;Proteins;Public Health;Renal clearance function;Research;Resistance;response;Second Messenger Systems;self assembly;Signal Transduction;Stable Disease;Stimulator of Interferon Genes;subcutaneous;success;Survival Rate;synergism;System;T cell infiltration;T cell response;T-Cell Activation;Techniques;Testing;therapeutic vaccine;Time;tool;treatment effect;Treatment Efficacy;tumor;Tumor Antigens;Tumor Expansion;tumor growth;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;whole genome

PROJECT_TITLE: Nanoscale Coordination Polymers of Cyclic-di-nucleotides and Peptide Antigens for Effective Therapy of Metastatic Colorectal Cancer

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding

PHR: MCBRC Project Narrative MOLECULAR AND CELL BIOLOGY RESOURCES CORE (MCBRC) The Molecular and Cell Biology Resources Core (MCBRC) will provide, development and training functions based on the variety of needs for advanced molecular/cell biology support by Louisiana Biomedical Research Network (LBRN) junior investigators. The main goals of the MCBRC are to: 1) Provide access to the sophisticated equipment and expertise of the biomedical research intensive (BRI) institutions throughout Louisiana, with the LSU flagship campus in Baton Rouge being the primary site (LSU School of Veterinary Medicine, LSU College of Science, Pennington Biomedical Research Center) 2) Train and support all LRBN investigators by helping them develop or adapt technological assays and methodologies needed for their projects.

PI_NAMEs: LEE, YONG-HWAN  (contact)

PROJECT_TERMS: Animal Experiments;Binding;Bioinformatics;Biological;Biological Assay;Biology;Biomedical Research;Biotechnology;Cancer Biology;Caring;Cellular biology;Centers of Research Excellence;Collaborations;college;Communicable Diseases;Communication;Consultations;Core Facility;Data;Databases;Development;Developmental Biology;Disease;Educational workshop;Electron Microscopy;Equipment;experience;Faculty;Fluorescence-Activated Cell Sorting;Funding;Gene Expression;Generations;Genetic;Genome;Goals;Health Sciences;Housing;Human Resources;Immunology;immunopathology;improved;in vivo imaging;Institution;interest;Internet;Laboratories;Lasers;Leadership;Louisiana;Lung;Medical center;Mentors;Methodology;Methods;Microscopy;Molecular;Molecular and Cellular Biology;Molecular Biology;Molecular Medicine;Monoclonal Antibodies;National Institute of General Medical Sciences;Neurobiology;new technology;next generation sequencing;operation;Pathology;Production;Proteins;Proteomics;Reagent;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schedule;Science;Scientist;Services;Site;structural biology;Students;Technical Expertise;Technology;Teleconferences;tool;Training;transcriptome;Translational Research;undergraduate student;United States National Institutes of Health;Universities;Veterinary Medicine;Veterinary Pathology;Veterinary Schools;Visit;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Relevance Supplementing vitamin B3 derivatives to increase nicotinamide adenine dinucleotide (NAD+) has recently shown promise in preclinical studies as a potential treatment for heart failure. However, this promise is based on a dosing strategy that may not be feasible in humans and much remains to be learned about the metabolism, mechanisms of action, and therapeutic potential of these molecules at doses that can be tolerated. The grant explores each of these questions using innovative surgical models, genetics, and state of the art mass spectrometry techniques.

PI_NAMEs: BAUR, JOSEPH A. (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Ablation;Activities of Daily Living;Address;Affect;American;aorta constriction;Arrhythmia;Biological Markers;Blood Pressure;Cardiac;Cardiac Myocytes;Caring;Cells;Cessation of life;Circulation;Citric Acid Cycle;cofactor;Data;dietary;Dose;Enzymes;experimental study;falls;Fatty Acids;Future;Generations;Genetic;Glucose;Grant;Health;Heart;Heart failure;heart function;heart rhythm;Human;Hydroxybutyrates;Hypertrophy;Impairment;improved;in vivo;innovation;Intervention Studies;Intestines;intraperitoneal;Intravenous;Ketones;Knockout Mice;Label;Learning;Liver;liver metabolism;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Myopathies;Modeling;Morbidity - disease rate;mortality;Mus;Myocardial Infarction;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;nicotinamide-beta-riboside;Nicotinic Acids;novel therapeutic intervention;Oral;Organ;oxidation;Oxidation-Reduction;Patients;Phenotype;Physiology;Pre-Clinical Model;preclinical study;Predisposition;Prevention;Proteins;Publishing;Regimen;Research;restoration;Rodent;Rodent Model;Role;Route;stable isotope;Stable Isotope Labeling;subcutaneous;sudden cardiac death;Supplementation;Surgical Models;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Time;Tissues;Titrations;tool;Tracer;Translations;Transplantation;Tryptophan;uptake

PROJECT_TITLE: Understanding the roles of cardiac NAD pools and therapeutic effects of precursor supplements in heart failure

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


PHR: DRPP Project Narrative  DEVELOPMENTAL RESEARCH PROJECT PROGRAM  The goal of the Developmental Research Project Program (DRPP) is to strengthen and expand  the research programs of the participating primarily undergraduate institutions (PUIs) through  funding and mentoring peer-reviewed research projects. These activities will increase the  research training of students, as well as the experiences of PUI faculty. The program will have  positive impacts on filling the pipeline of biomedical scientists within the state and expanding the  workforce.

PI_NAMEs: STANFIELD, BRENT A (contact)

PROJECT_TERMS: Advisory Committees;American Association for the Advancement of Science;Biomedical Research;biomedical scientist;Center for Translational Science Activities;Clinical Sciences;Collaborations;Development;Evaluation;experience;Faculty;faculty mentor;Funding;Goals;Grant;Infrastructure;Institution;instrumentation;Laboratories;Laboratory Research;Logic;Louisiana;Mentors;Modeling;peer coaching;Peer Review;Pilot Projects;Process;Program Research Project Grants;programs;Research;research and development;Research Infrastructure;Research Peer Review;Research Personnel;Research Project Grants;Research Training;student training;Students;success;Translational Research;undergraduate student


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Clinical Research;Osteoarthritis;Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Fractures due to osteoporosis remain a major health concern that drastically hinders the quality of life, especially among the elderly, and incurs large medical costs. To facilitate the development of new clinical tools that assess the contribution of bone matrix quality to fracture risk and the identification of new mechanisms involved in bone fragility, this project will ascertain whether non-enzymatic post-translational modifications (NE-PTMs) of collagen are predictors of poor fracture resistance of human bone and whether their levels are specifically greater in those with osteoporosis than individuals without the disease. Furthermore, by employing matrix manipulation studies and molecular modeling, we will assess the effect of non-crosslinking vs. crosslinking NE-PTMs on fracture resistance and identify a mechanism by which NE-PTMs affect collagen structure and hydration, respectively.

PI_NAMEs: NYMAN, JEFFRY STEPHEN (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Affect;Age;age related;Age Years;Aging;Amino Acids;aminoguanidine;Binding;Biophysical Process;bone;Bone Density;Bone Diseases;bone fragility;bone health;bone mass;Bone Matrix;Bone Resorption;Bone Tissue;Cadaver;Characteristics;Charge;Clinical Assessment Tool;Clinical assessments;Clinical Management;clinically relevant;Collagen;Collagen Fibril;cortical bone;cost;crosslink;Data;deamidation;Degenerative polyarthritis;Deterioration;Development;Differential Scanning Calorimetry;Disease;Elderly;Electrostatics;experience;Extracellular Matrix;Extracellular Matrix Proteins;Fatigue;Female;Femoral Neck Fractures;Femur;Fracture;fracture risk;fragility fracture;Funding;Glucose;Glutamine;Goals;Growth;Health;Hip Fractures;Hip Osteoarthritis;hip replacement arthroplasty;Human;humerus;Hydration status;Hydrogen Bonding;Impairment;Individual;inhibitor;Isometric Exercise;Knowledge;Link;male;Mass Spectrum Analysis;mechanical properties;Mechanics;Medical Care Costs;Modeling;models and simulation;Modification;molecular dynamics;molecular modeling;mouse model;N(6)-carboxymethyllysine;Operative Surgical Procedures;Orthopedic Surgery;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Pathogenicity;Patients;Pattern;Pentetic Acid;pentosidine;Positioning Attribute;Post-Translational Protein Processing;preservation;prevent;Proteins;Pyruvaldehyde;Quality of life;Resistance;Role;Sampling;Site;Specimen;Spinal Fractures;Statistical Models;Structure;Study models;substantia spongiosa;Techniques;Testing;Time;triple helix;Vertebral column;Water

PROJECT_TITLE: Roles of Collagen and Water in the Fracture Resistance of Bone

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Diseases of the bile ducts are an important cause of liver failure in the adult and pediatric populations. We have discovered differences in the way bile duct cells respond to environmental stress and will examine the underlying causes and their relevance to human biliary diseases.

PI_NAMEs: PACK, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Adult;Affect;analog;Antioxidants;Award;bile duct;Bile Duct Diseases;Bile Duct Epithelium;Bile fluid;bile salts;Biliary;Biliary Atresia;biliary tract;biological adaptation to stress;Biology;Body Fluids;Caustics;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;cellular targeting;Characteristics;Child;Childhood;cholangiocyte;Client;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Congenital atresia of extrahepatic bile duct;Consumption;CRISPR screen;Cyclic GMP;Data Correlations;Detergents;Development;Disease;Disease Outbreaks;disorder risk;DNA-Directed DNA Polymerase;Duct (organ) structure;Ductal Epithelial Cell;Epidemic;Epigenetic Process;Epithelial Cells;experimental study;Exposure to;Extrahepatic;Genes;genome-wide;Glutathione Disulfide;Glutathione Metabolism Pathway;Goals;Heat-Shock Response;Heterogeneity;Human;human disease;In Vitro;in vivo;Incidence;Injury;intrahepatic;Knowledge;Laboratories;Link;Liver Failure;liver transplantation;Livestock;macromolecule;Mass Spectrum Analysis;Mediating;Mediator;Metabolism;Mitochondria;Modeling;Molecular;Molecular Chaperones;mouse model;multicatalytic endopeptidase complex;Mus;Mutate;Mutation;novel;novel therapeutics;Organelles;Outcome;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathogenesis;Physiological;Plants;Play;Population;Predisposition;prevent;Property;Proteome;Proteomics;proteostasis;proteotoxicity;Publishing;Reactive Oxygen Species;Reduced Glutathione;Regional Anatomy;regional difference;Research;response;Risk;Risk Factors;Role;Signal Transduction;Stress;System;Toxic effect;Toxin;Variant;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Redox and Proteomic Stress Responses in Biliary Disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: STRASBOURG

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INSERM STRASBOURG

PHR: Narrative In opioid use disorders (OUDs), withdrawal from chronic opioids is characterized by a negative affective state that enhances the risk of relapse and overdose, however underlying circuit mechanisms remain elusive. Here we focus on the habenula, a known brain aversion center. We hypothesize that neurons of the habenula, which express the mu opioid receptor (MOR), are key to aversive emotional states of morphine withdrawal. We combine opto/chemogenetics in a novel MOR-Cre line with behavioral paradigms of short- & long-term morphine withdrawal and cutting-edge animal MRI to investigate a novel circuit hypothesis, which we think relevant to OUDs 1

PI_NAMEs: KIEFFER, BRIGITTE L. (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Animals;Automobile Driving;Behavior;Behavioral;Behavioral Model;Behavioral Paradigm;Brain;Chronic;Clinical;Complement;Data;depressive symptoms;Development;Emotional;emotional experience;Exposure to;Face;fighting;Functional Magnetic Resonance Imaging;Genetic;Habenula;Human;innovation;Laboratories;Magnetic Resonance Imaging;Medial;Mediating;Medicine;Mental Depression;Modeling;Moods;Morphine;mu opioid receptors;Mus;Naloxone;naloxone dosing;negative affect;neural circuit;Neural Pathways;neuroimaging;neuromechanism;Neurons;North America;novel;Opioid;opioid abuse;opioid epidemic;opioid use;opioid use disorder;opioid withdrawal;optogenetics;Outcome;Overdose;overdose death;Pain;pain relief;Pattern;Play;Property;Publications;raphe nuclei;receptor;receptor function;Recovery;relapse prevention;relapse risk;Research;response;Rewards;Role;social deficits;Social Interaction;Testing;Time;Transgenic Organisms;translational potential;Universities;Withdrawal

PROJECT_TITLE: Morphine-responsive neurons of the medial habenula : a role in aversive states of morphine withdrawal ?

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Understanding the role of social media platforms and their underlying algorithms in surfacing common mispercep- tions surrounding medication assisted treatment (MAT) for opioid use disorder (OUD) is key towards sustained recovery. By leveraging robust audit methodologies to investigate algorithmic pathways of MAT misinformation (MATM), coupled with machine learning techniques to detect the prevalence of MATM on Twitter, this project will conduct mixed methods evaluations of the developed computational artifacts relating to an hitherto unexplored- but-significant phenomenon in the OUD medication and treatment domain. The research will shine new light on the relation between an individual’s online information environment and risky OUD behavior, and offer formative insights to initiate evidence-based interventions to reduce such risks.

PI_NAMEs: MITRA, TANU  (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: addiction;Address;Affect;Age;Algorithm Design;Algorithms;Automobile Driving;Awareness;Behavior;Behavior Disorders;Behavior Therapy;behavioral health;Black Box;Cause of Death;Characteristics;Clinical;Clinical Treatment;computer scientist;cost effective;Counseling;Coupled;COVID-19 pandemic;Dangerousness;Data;design;detection method;Diagnosis;disorder risk;Early Diagnosis;empowerment;Environment;Epidemic;Evaluation;Evidence based intervention;experimental study;explainable machine learning;Exposure to;Facebook;Foundations;Future;Gender;Goals;Health;health literacy;Improve Access;improved;Individual;Infrastructure;innovation;insight;Intelligence;interest;Internet;Intervention;Interview;Investigation;Knowledge;Letters;Light;Location;Machine Learning;machine learning method;Measures;media use;medication for opioid use disorder;medication-assisted treatment;Methodology;Methods;Misinformation;Morphologic artifacts;multidisciplinary;National Institute of Drug Abuse;Natural Language Processing;new technology;novel;online resource;opioid misuse;opioid overdose;opioid use disorder;Outcome;overdose risk;Participant;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Policies;Prevalence;prevent;Psychologist;Public Health;Qualitative Evaluations;Reaction;Recommendation;Recovery;recruit;Rehabilitation therapy;Research;Research Design;Resources;response;Risk;Risk Behaviors;Risk Reduction;Role;sharing platform;Site;social media;social stigma;Sorting;standard care;Statistical Data Interpretation;Strategic Planning;substance misuse;Substance Use Disorder;Surface;sustained recovery;Symbiosis;System;Techniques;Technology;Time;tool;Treatment outcome;Twitter;United States;Work

PROJECT_TITLE: Auditing Social Media Algorithmic Pathways to Measure Prevalence of Online Misinformation Related to Opioid Misuse

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-J(90)S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: NARRATIVE Chikungunya is an emerging vector-borne virus that is becoming endemic in the Americas. Using experimental evolution and functional genetic approaches, we will explore the relative importance of genetic diversity for virus transmission and the evolution of resistance to viruses in mosquitoes. Our project will inform strategies for developing broad-spectrum, virus-resistant mosquitoes via genetic modification, and for developing epidemiological risk maps for chikungunya globally.

PI_NAMEs: MCGRAW, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Aedes;Affect;African;Americas;Arboviruses;Area;Arthritis;Asian;Candidate Disease Gene;candidate identification;Caribbean region;Cells;chikungunya;chikungunya infection;Chikungunya virus;Chronic;Cost of Illness;Country;CRISPR/Cas technology;Culicidae;Dengue Virus;Development;Disease;Disease Outbreaks;Distant;E protein;env Gene Products;Epidemiology;Evolution;experience;Family;fitness;Future;Gene Proteins;General Practitioners;Genes;Genetic;genetic approach;genetic architecture;genetic resistance;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Genomics;Heritability;Immune response;improved;In Vitro;Indian Ocean;Individual;Infection;invention;Island;Knowledge;Latin America;Link;Maps;Measures;Mediating;Methods;Modification;Morbidity - disease rate;Mutagenesis;Mutation;novel;Outcome;Pathway interactions;Pharmacotherapy;Phenotype;Population;Predisposition;Public Health;Refractory;Reporter;Reporting;Resistance;Risk;RNA Interference;Role;Salivary Glands;Shapes;Site-Directed Mutagenesis;South African;stem;System;Techniques;Testing;Time;Tissues;tool;transmission process;Vaccines;Variant;vector;vector competence;vector control;vector mosquito;vector-borne;Viral;Viral Genome;viral resistance;viral transmission;Viral Vector;Virus;Work

PROJECT_TITLE: Exploring the coevolutionary potential of chikungunya virus and its Aedes mosquito vectors

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Alzheimer’s Disease (AD) poses an increasingly large public health burden. By providing new insights into the role of neuroinflammation in AD, this study will provide the foundation for future advances in prognostication and targeted anti-inflammatory therapies for this devastating disease.

PI_NAMEs: GUPTA, AJAY  (contact);RAJ, ASHISH

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Address;Affinity;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;animal data;Anti-Inflammatory Agents;Atrophic;Biological;Biological Markers;Biological Models;Brain;brain magnetic resonance imaging;Cerebrospinal Fluid;Clinical;clinical application;clinical heterogeneity;Cognition;Cognitive;Computer Models;Dementia;density;Diagnosis;Diagnostic;Diffusion;Disease;disease model;disease phenotype;Disease Progression;Education;Etiology;follow-up;Foundations;Functional disorder;Future;Generations;genetic risk factor;glial activation;Glucose;Goals;Human;Image;imaging study;in vivo;Inflammation;Inflammatory;inflammatory marker;insight;Investigation;Kinetics;Laboratories;Ligands;Linear Models;Longitudinal cohort;longitudinal, prospective study;Machine Learning;Magnetic Resonance Imaging;mathematical model;Measures;Mediating;Mediation;Microglia;model design;Modeling;Modernization;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;neurotransmission;novel;older adult;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Positron-Emission Tomography;predictive modeling;predictive test;prognostication;Property;Protocols documentation;Public Health;Race;Research;Role;Science;Senile Plaques;Series;Serum;sex;Signal Transduction;spatiotemporal;Specificity;Speed;Statistical Models;systemic inflammatory response;tau aggregation;tau interaction;tau mutation;tau Proteins;Testing;Time;tractography;transmission process;TREM2 gene;Visit

PROJECT_TITLE: Understanding the dynamic interactions between tau pathology and microgliamediated inflammation in Alzheimer's Disease


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Cell therapies have the potential to revolutionize disease treatment, but require more complex, variable and costly production methods. The main goal of this project is develop aptamer-based technologies for traceless cell selection in manufacturing of cell therapies. We anticipate that the proposed research will lead to next generation technologies relevant for scalable and more affordable production of CAR T cell immunotherapy, monocyte-based cell therapies and stem cell treatments.

PI_NAMEs: PUN, SUZIE H. (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Adoption;Antibodies;aptamer;Autologous;Binding;Biological;Biomanufacturing;CAR T cell therapy;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cell Survival;Cell Therapy;cell transformation;Cells;Cellular immunotherapy;chimeric antigen receptor T cells;Clinic;Clinical;Clinical Treatment;Clinical Trials;Collection;Complex;cost;Data;Dendritic Cells;Development;Diabetes Mellitus;Disease;DNA;Engineering;Ensure;Ethics;Gene Expression Profiling;gene product;Generations;glycosylation;Goals;Harvest;Heart Diseases;Hematologic Neoplasms;Human;Immune Targeting;Immunotherapy;improved;innovation;Logistics;Macrophage;Magnetism;manufacture;Membrane Proteins;Methods;monocyte;next generation;novel;Outcome;peripheral blood;Pharmaceutical Preparations;Phenotype;Population;Production;proteoliposomes;receptor;Recombinants;regenerative;Regenerative Medicine;Reporting;Reproducibility;Research;response;Sampling;SELL gene;small molecule;Source;Speed;Spinal cord injury;stem cell therapy;stem cells;success;T cell therapy;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Technology;technology platform;Therapeutic;Time;TNFRSF6 gene;Translations;Urine

PROJECT_TITLE: Traceless, aptamer-based cell isolation for cell therapy applications

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Relevance to Public Health This proposal will study novel compounds against glioblastoma to induce neuron-like forced differentiation in response to radiation. The overall goal is to improve the efficacy of radiation treatment for glioblastoma patients.

PI_NAMEs: PAJONK, FRANK  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Affect;Animal Model;Area;Blood - brain barrier anatomy;blood-brain barrier crossing;cancer cell;cancer therapy;Cell Differentiation process;Cell Line;Cells;chemotherapy;Chemotherapy and/or radiation;Chromatin;Clonal Evolution;Data;Development;differentiation protocol;Disease;Exhibits;Generations;Genotoxic Stress;Glioblastoma;Glioma;Goals;Heterogeneity;Hypoxia;improved;in vivo;Induced Neurons;inhibitor;Malignant Neoplasms;mouse model;neuronal circuitry;novel;novel strategies;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Population;prevent;Process;programs;Promoter Regions;Public Health;Radiation;radiation response;Radiation therapy;radioresistant;Recurrence;Research;Resistance;Role;Solid;standard of care;stem cells;stemness;success;Testing;therapy outcome;transcription factor;Treatment Failure;tumor;Xenograft procedure

PROJECT_TITLE: Utilizing Radiation-Induced Multi-potency to Increase the Efficacy of Radiotherapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHAMPAIGN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Molecular chirality is at the heart of biological function, disease and development. While vibrational circular dichroism (VCD) can precisely measure molecular chirality and, consequently, molecular structure, available instrumentation can only record data from bulk samples. This instrument development project seeks to develop a prototype, termed VCD imaging microscope or VIM, to record chirality from microscopically heterogeneous biomedical samples.

PI_NAMEs: BHARGAVA, ROHIT  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Algorithms;Amyloid;analytical method;Basic Science;Biogenesis;Biological;Biological Process;biological research;Biomedical Research;Chemicals;Circular Dichroism Spectroscopy;clinical diagnostics;Complex;Computer software;Custom;Data;Data Analyses;data management;data visualization;Dependence;Deposition;design;Development;Device or Instrument Development;Disease;DNA;Drug Design;Electronics;enantiomer;experience;Feasibility Studies;Fingerprint;Fourier Transform;Frequencies;Goals;Handedness;Health;Heart;Hour;Human;Image;Imaging Device;Imaging technology;instrument;instrumentation;Intervention;Knowledge;Lasers;Life;Light;Maps;Measurable;Measurement;Measures;Medical;Microscope;Microscopic;microscopic imaging;Microscopy;Modeling;Modernization;Molecular;Molecular Profiling;Molecular Structure;Morphologic artifacts;new technology;Noise;novel;Nucleic Acids;Optics;Peptides;Performance;Pharmaceutical Preparations;Process;prototype;Publishing;quantum;Reporting;Research;Sampling;Scanning;Science;Signal Transduction;Site;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Speed;sugar;System;Techniques;Technology;technology development;technology research and development;temporal measurement;Testing;Theoretical model;theories;Time;timeline;Tissue Sample;tool;transmission process;Validation;Vibrational Circular Dichroism;Work

PROJECT_TITLE: Instrument development for vibrational circular dichroism imaging

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE. Adolescent alcohol abuse causes progressive neurodegeneration that parallels Alzheimer’s disease-related pathology, including chronic neuroinflammation, persistent degeneration of basal forebrain cholinergic neurons, hippocampal neurodegeneration, and lasting cognitive deficits. The proposed studies will investigate adolescent alcohol abuse as a novel etiological factor priming and accelerating progression of basal forebrain and hippocampal neurodegeneration with age to Alzheimer’s disease. Prevention studies will link adolescent neuroinflammation and cholinergic degeneration to age-related neurodegeneration and cognitive deficits observed in human Alzheimer’s disease and provide new therapeutic targets.

PI_NAMEs: VETRENO, RYAN PETER (contact)

PROJECT_TERMS: abeta accumulation;Acceleration;Acetylcholine;Adolescence;Adolescent;adolescent alcohol abuse;adolescent alcohol exposure;adolescent binge drinking;Adult;Age;age related neurodegeneration;Aging;aging brain;Agonist;Alcohols;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;amyloid induced neuroinflammation;antagonist;Anti-Inflammatory Agents;Autopsy;basal forebrain;basal forebrain cholinergic neurons;Brain;cholinergic;cholinergic neuron;Cholinesterase Inhibitors;Chronic;Cognition;Cognitive deficits;cognitive function;Crossbreeding;Data;DDX6 gene;Dementia;dentate gyrus;Development;drinking onset;Electrophysiology (science);Ethanol;Etiology;Female;Fiber;FPS-FES Oncogene;Functional disorder;Genes;Genetic;Genetic Diseases;glial activation;Hippocampus;Human;Impaired cognition;Impairment;in vivo;Individual;innovation;Intervention;Laboratories;Life;Link;male;Male Adolescents;mouse model;Mus;Nerve Degeneration;neurogenesis;Neuroimmune;neuroinflammation;neuron loss;neuropathology;new therapeutic target;novel;novel therapeutics;optogenetics;Pathology;Photometry;prevent;Prevention;progressive neurodegeneration;Proto-Oncogene Proteins c-abl;receptor for advanced glycation endproducts;Receptor Inhibition;response;Reverse Transcriptase Polymerase Chain Reaction;Rodent;Role;Sampling;Signal Transduction;Slice;Source;Tauopathies;Testing;Therapeutic;transmission process;Western Blotting

PROJECT_TITLE: Adolescent Alcohol in 5xFAD Mouse Model Accelerates Neuroinflammation and Alzheimer's Disease Pathology Across Aging


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed work aims to understand how the adolescent brain encodes behavioral states. These studies are critical for advancing our understanding of how the seemingly natural adolescent development may predispose them to cognitive and affective dysfunction.

PI_NAMEs: MOGHADDAM, BITA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Adolescent;Adolescent Development;Adult;Affective;Age;Association Learning;Behavior;Behavioral;Brain;Brain Diseases;Characteristics;Cognitive;Corpus striatum structure;Cues;Data;Detection;Development;Dopamine;dopaminergic neuron;Dorsal;Electrophysiology (science);Event;expectation;Functional disorder;Funding;Genetic;Lateral;Learning;learning outcome;mature animal;Medial;Mediating;Methods;Midbrain structure;Modeling;Mood Disorders;motivated behavior;neural;Neurons;Nucleus Accumbens;optogenetics;Oranges;Outcome;Pathway interactions;Pattern;Phenotype;Prevention;Process;Rattus;response;Rewards;Rodent;Schizophrenia;Signal Transduction;Substantia nigra structure;Suicide attempt;Testing;tool;Ventral Tegmental Area;Work

PROJECT_TITLE: Neural basis of learning and response inhibition in adolescents


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_DEPT: NUTRITION

PHR: NARRATIVE Ceramides are products of fat and protein metabolism that accumulate in individuals with obesity or dyslipidemia. Herein we investigate their contribution to cancers in the gastrointestinal tract by dissecting their impact on the ability of intestinal stem cells to use nutrients and proliferate. The work could uncover new therapeutic approaches for combating gastrointestinal cancers associated with obesity.

PI_NAMEs: EDGAR, BRUCE ALEXANDER;SUMMERS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;Adenocarcinoma;Amino Acids;Anabolism;Architecture;Automobile Driving;base;cancer therapy;Cancerous;Carbohydrates;cell behavior;Cell Survival;Cells;Cellular Metabolic Process;Ceramides;Chronic;conditional knockout;CRISPR interference;CRISPR-mediated transcriptional activation;crypt cell;Cues;Data;deprivation;detection of nutrient;Detergents;Diet;dietary;Dietary Fats;Drosophila genus;Dyslipidemias;Enzymes;Epithelium;epithelium regeneration;FABP1 gene;fatty acid oxidation;Fatty Acid-Binding Protein 1;Fatty Acids;fly;gastrointestinal;Gastrointestinal Neoplasms;Gastrointestinal tract structure;Genes;Genetic;Genetic Transcription;Glucose;glucose metabolism;Growth;gut health;High Fat Diet;Human;Hyperplasia;improved;Individual;Inflammation;intestinal epithelium;intestinal villi;Intestines;Knockout Mice;Lesion;Link;lipid metabolism;Lipids;Macronutrients Nutrition;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Midgut;mouse model;Mus;Natural regeneration;novel;novel therapeutic intervention;Nutrient;Nutritional;Obesity;obesogenic;Organoids;oxidation;Palmitates;Palmitoyl Coenzyme A;Permeability;pharmacologic;Physical condensation;Play;PPAR alpha;programs;Proliferating;protein metabolism;response;Risk;Role;scaffold;Science;Serine;serine palmitoyltransferase;Signal Transduction;Sphingolipids;stem cell proliferation;stem cells;stemness;Structure;Testing;tissue regeneration;Tissues;Transgenic Mice;tumor;Tumor Burden;tumorigenesis;Tumorigenicity;uptake;Work

PROJECT_TITLE: The Role of Ceramides in the Intestinal Stem Cell

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative We focus on studying non-canonical forms of coding (temporal coding and “analog” coding) to delineate the molecular, biophysical, and circuit mechanisms that underlie neural coding and behavior. We have identified 2 neural circuits in Drosophila that allow for exquisite experimental control and where the impact of temporal pattern codes or analog codes on both target neuron physiology and animal behavior can be rigorously investigated. This study will contribute to the understanding of the fundamental principles that underlie how neural codes generate neurophysiological signals and behavior.

PI_NAMEs: TABUCHI, MASASHI  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;analog;Animal Behavior;Axon;Behavior;Biochemical;Biological Models;Biophysics;circadian regulation;Code;deprivation;digital;Drosophila genus;Elements;Event;Exhibits;feeding;Feeding behaviors;Genetic;Genetic Models;Hippocampus;Hunger;Hybrids;information processing;Mammals;Mediating;Membrane Potentials;Modeling;Molecular;Molecular Mechanisms of Action;neural;neural circuit;Neurobiology;Neuronal Plasticity;Neurons;neurophysiology;novel;Pathway interactions;Pattern;Physiology;presynaptic;Process;Proteins;response;Retina;Role;Scheme;Signal Transduction;sleep quality;sleep regulation;Structure;sugar;Synapses;Synaptic plasticity;Work

PROJECT_TITLE: The role of non-canonical neural codes in behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Infectious pneumonia remains an urgent public health threat, causing millions of worldwide deaths each year and leading to chronic pulmonary and extrapulmonary complications in many survivors. The discovery that therapeutic manipulation of lung epithelial antimicrobial responses can robustly protect hosts against an expansive array of bacterial, viral and fungal pathogens despite impairment of leukocyte function offers a novel opportunity to protect vulnerable populations against these outcomes. This proposal supports a program investigating the mechanisms underlying the unique synergistic signaling events that drive protection, the effector molecules that yield staggeringly broad protection, and the regulatory events that promote durable protection, so that this protective phenomenon can be translated to maximally protect susceptible patients.

PI_NAMEs: EVANS, SCOTT E. (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Pneumonia;Address;Agonist;Alveolar Cell;Amplifiers;anti-microbial peptide;antimicrobial;Area;Asthma;Cessation of life;Chronic;Chronic lung disease;Clinic;Data;design;Detection;Development;efficacious intervention;Environment;Epithelial Cells;Epithelium;Event;Generations;Health;Immunocompromised Host;immunopathology;immunoregulation;Impairment;Infection;Inhalation Therapy;Investigation;Leukocytes;Lung;Mediator;Mucous Membrane;Mus;novel;Outcome;pathogen;pathogenic bacteria;pathogenic fungus;pathogenic virus;Patients;Pattern recognition receptor;Pneumonia;Population;Predisposition;prevent;Production;programs;Public Health;Reactive Oxygen Species;Resistance;response;Scientific Advances and Accomplishments;sensor;Signal Transduction;Source;Specific qualifier value;Surface;Survivors;Technology;Therapeutic;Time;Training;Translating;Translations;Volatilization;Vulnerable Populations

PROJECT_TITLE: Inducible epithelial resistance: a program investigating mechanisms to protect against acute and chronic complications of pneumonia


ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: Project Narrative Energy failure, or insufficient energy to support normal function, can lead to a wide range of diseases of aging including neurodegenerative and heart diseases, but we do not know how to treat it. In this proposal, we will define the most robust mechanisms by which cells regulate their energy levels, and determine if targeting these boosts the function and survival of human cells that are susceptible to diseases of energy failure. These studies will determine how to most effectively increase cellular energy levels, and begin to assess the therapeutic potential of increasing energy in diseases of energy failure.

PI_NAMEs: NAKAMURA, KEN  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Aging;aging related disease;anti aging;Bioenergetics;Biological Assay;Biosensor;Cardiac Myocytes;Cell Line;Cell Physiology;cell type;Cells;Cessation of life;Consumption;CRISPR interference;CRISPR-mediated transcriptional activation;deprivation;Disease;Energy consumption;Energy Metabolism;experimental study;Failure;Fluorescence Resonance Energy Transfer;Fluorescence-Activated Cell Sorting;Functional disorder;Gene Expression;Genes;Genetic;Genetic Epistasis;Genetic Transcription;Glycolysis;Goals;Heart Diseases;Heart failure;high throughput screening;Human;hypoxia inducible factor 1;improved;Individual;innovation;Ischemia;K562 Cells;Leukemic Cell;Libraries;Malignant Neoplasms;Measures;Mediating;Mediator;Metabolic;metabolomics;Mitochondria;Neurodegenerative Disorders;Neurons;Oxygen;Pathway interactions;Predisposition;preservation;Production;protective effect;Respiration;respiratory;Respiratory physiology;Role;sensor;Synapses;Testing;Therapeutic;transcriptomics;whole genome

PROJECT_TITLE: Defining Strategies to Target Energy Failure in Metabolically Vulnerable Human Cells

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

PHR: Narrative Immunoglobulin A (IgA) antibodies are prominently secreted in the intestines and coat a fraction of the intestinal bacterial microbiota. Nothing is currently known about the potential involvement of IgA antibody responses in control of and immunity to intestinal fungal microbiota (mycobiota) coexisting with bacteria at this body site. Here we will study the role of IgA antibodies in immunity against specific intestinal fungi and virulence factors by these organisms to determine if these antibodies can protect the intestines against fungi-fueled inflammation.

PI_NAMEs: ILIEV, ILIYAN DIMITROV (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Affect;anti-fungal agents;Antibodies;Antibody Repertoire;Antibody Response;B-Lymphocytes;Bacteria;Binding;Biological;Biological Models;Candida;Candida albicans;Catalogs;cell type;Collection;commensal bacteria;computational platform;conditional knockout;crosslink;CX3CR1 gene;Data;dectin 1;deep sequencing;Defect;Development;Disease;dysbiosis;Epitopes;Equilibrium;Event;fractalkine receptor;Fungal Components;fungal microbiota;fungus;gastrointestinal;Gastrointestinal tract structure;Gene Modified;Genes;Genetic;Genetic Polymorphism;Germ-Free;Growth;gut colonization;gut inflammation;gut microbiota;Health;Homeostasis;Human;Hyphae;IgA Deficiency;Immune response;Immunity;immunogenic;Immunoglobulin A;In Vitro;in vivo Model;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal barrier;Intestinal Diseases;intestinal epithelium;Intestines;Invaded;Knock-out;Knockout Mice;Lead;Link;Lymphoid Tissue;Measures;member;Metabolic;Microbe;microbial;microbiota;microbiota composition;mouse model;Mouse Strains;Mucosal Immunity;Mucous Membrane;Mus;Mycoses;novel;Organism;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phagocytes;Play;Population;prevent;Process;Property;Regulation;Reporter;response;Role;Scanning;Secondary to;Secretory Immunoglobulin A;sequencing platform;Site;Specificity;Surface;SYK gene;Techniques;Testing;Toxin;treatment response;Virulence Factors;Virus;Work;Yeasts

PROJECT_TITLE: Regulation and function of mucosal IgA immune responses to mycobiota in the gut.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-E(57)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Anxiety Disorders;Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Rare Diseases;Tuberous Sclerosis

ORG_CITY: GREENSBORO

ORG_NAME: NORTH CAROLINA AGRI & TECH ST UNIV

PHR: PROJECT NARRATIVE While individuals with epilepsy are often diagnosed with autism spectrum disorder (ASD) and anxiety disorders, the underlying neurobiological reasons for this co-occurrence are poorly defined. The current studies in preclinical models of TSC, which exhibit seizures, ASD and anxiety-like behaviors, seek to build a framework that can define the molecular mechanisms linking these disorders. Insights into the underlying mechanisms will enhance the development of rational therapeutics for comorbid neurological and neuropsychiatric diseases.

PI_NAMEs: NIERE, FARR  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Affect;Anatomy;Anxiety;Anxiety Disorders;anxiety-like behavior;associated symptom;autism spectrum disorder;Behavioral;Behavioral Assay;Biological;Biological Models;Brain Diseases;Calcium Channel;Calcium Channel Agonists;Cell membrane;Central Nervous System;Chronic;Communication;comorbidity;Complex;Data;Dendrites;Development;Diagnosis;Disease;efficacy evaluation;Environment;Epilepsy;Exhibits;FRAP1 gene;Frequencies;Functional disorder;General Population;Genetic;Genetic Diseases;graduate student;Historically Black Colleges and Universities;Hyperactivity;improved;Individual;Injections;insight;Institution;Investigation;Knockout Mice;L-Type Calcium Channels;Link;link protein;Literature;loss of function mutation;Mediating;Medical;Mental disorders;Messenger RNA;Molecular;mouse model;mRNA Translation;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurobiology;Neurons;neuropsychiatric disorder;Neurosciences Research;Newborn Infant;North Carolina;novel;overexpression;PARK7 gene;Pathologic;Pathway interactions;Patients;Peripheral;pharmacologic;Pharmacotherapy;Phosphotransferases;Pre-Clinical Model;programs;Protein Biosynthesis;protein expression;Protein Synthesis Inhibition;Proteins;Regulation;Repression;Research;Research Personnel;RNA-Binding Proteins;Rodent Model;Science;Seizures;Signal Pathway;Signal Transduction;Social Phobia;Students;Subcellular structure;Symptoms;Synapses;synaptic function;synaptic inhibition;Testing;Therapeutic;tool;trafficking;Translational Repression;Translations;TSC1 gene;TSC2 gene;Tuberous Sclerosis;undergraduate student;Universities;Work

PROJECT_TITLE: Evaluating dendritic DJ-1 targets as a framework for identifying pharmacotherapies for TSC-related neurological disorders


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Macrophages and fibroblast-like synoviocytes (FLS) are cells present in inflamed joints that have been implicated in the pathogenesis of rheumatoid arthritis (RA). The long-term goals of this project are to understand how cytokines and inflammatory factors expressed in RA joints (synovium) activate these cells to drive inflammation and the disease process. This project will investigate how signaling pathways activated in RA synovium regulate macrophage inflammatory responses to gain knowledge that can be used to increase anti-inflammatory signaling and more effectively treat patients with rheumatoid arthritis.

PI_NAMEs: IVASHKIV, LIONEL B (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acidosis;Adenosine;Anti-Inflammatory Agents;Antigen-Antibody Complex;autocrine;Behavior;Biopsy;cell type;Cells;chemokine;Chromatin;Chromatin Modeling;Coculture Techniques;CSF3 gene;Cyclic AMP;Cyclic AMP Receptors;cytokine;Dinoprostone;Disease;DTR gene;effective therapy;Epigenetic Process;Equilibrium;Exhibits;Fibroblasts;G-Protein-Coupled Receptors;Gene Expression;Genes;genetic signature;Genetic Transcription;Goals;Growth Factor;Human;Immune;In Vitro;in vivo Model;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Response;Interferons;Interleukin-1;Interleukin-6;Invaded;joint inflammation;Joints;Knowledge;Lymphocyte;Macrophage;Macrophage Activation;Matrix Metalloproteinases;Mediating;molecular modeling;Neuropeptides;novel therapeutics;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Process;Production;programs;Property;Prostaglandins;recruit;Regulation;Regulatory Element;response;Rheumatoid Arthritis;Role;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;STAT4 gene;synergism;Synovial Cell;Synovial Membrane;Synovitis;System;targeted treatment;Testing;Therapeutic;Tissues;TNF gene;Treatment Efficacy;WFDC2 gene

PROJECT_TITLE: Cytokine regulation of RA synoviocyte phenotype

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE The goal of this project is to dissect the mechanisms of protection against Shigella dysentery by studying the evolution of naturally acquired immunity in a longitudinal mother-infant cohort from Malawi; we will interrogate the biophysical and functional properties of maternal antibodies in sera and breast milk and immunity in infants from birth to 2 years of age. Naturally acquired antibodies will also be monitored longitudinally in a cohort of Malawian children 2-5 years of age. The research proposed is novel and has the potential to identify immune components associated with protective immunity in children, which can inform the development of vaccines and therapeutics for the most vulnerable.

PI_NAMEs: PASETTI, MARCELA F (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 2 year old;3 year old;5 year old;acquired immunity;adaptive immunity;Adult;Affect;Age;Age Months;Antibiotic Resistance;Antibiotics;Antibodies;antibody transfer;Antigens;antimicrobial;Antimicrobial Resistance;B-Lymphocytes;Biological Assay;Biophysics;Birth;Blood Cells;Cells;Cellular Immunity;Cessation of life;Child;Child Care;Childhood;Clinical;Clinical Data;clinically relevant;cohort;Data;design;Developed Countries;Development;Diarrhea;diarrheal disease;Disease;Disease Outbreaks;Drug resistance;Dysentery;efficacy testing;Elements;Engineering;enteric infection;epidemiology study;Evolution;Exhibits;experience;Exposure to;field study;Goals;Growth;Human;Human Engineering;Human Milk;human monoclonal antibodies;Immune;Immune response;Immunity;Immunoglobulin A;Immunologic Markers;Immunologics;Immunotherapeutic agent;Immunotherapy;Impaired cognition;in vitro Assay;in vivo;Incidence;Infant;Infection;Infection prevention;infection risk;innovation;Invaded;Knowledge;Knowledge acquisition;Life;Lifelong disability;longitudinal analysis;Longitudinal cohort;low and middle-income countries;Malawi;Maps;Maryland;Maternal antibody;Maternally-Acquired Immunity;Mediating;Monitor;Monoclonal Antibodies;monocyte;mortality;Mothers;Multi-Drug Resistance;Mus;neutrophil;novel;novel therapeutics;Organism;pathogen;Pediatric cohort;Perinatal Infection;Phagocytes;Phagocytosis;Placenta;Plasmids;Polysaccharides;Predisposition;prevent;Property;protective efficacy;Protein Engineering;Proteins;Recombinants;Research;resistant strain;Resources;response;Risk Reduction;Rotavirus;Serology;Serum;Shigella;Shigella Infections;Specificity;Specimen;success;System;T-Lymphocyte;Technology;Testing;Therapeutic;Time;Toddler;tool;trend;Umbilical Cord Blood;Universities;vaccine development;Vaccine Therapy;Vaccines;Virulent;Vulnerable Populations;Work

PROJECT_TITLE: Mechanisms of protection against shigellosis in children

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biotechnology;Breastfeeding, Lactation and Breast Milk;Gene Therapy;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Because antiretroviral therapy alone is unlikely to end the morbidity and mortality associated with mother- to-child transmission of HIV, there is considerable interest in developing immune-based interventions to combat perinatal HIV infection. Here we will use the pediatric rhesus macaque model of HIV/AIDS to assess whether gene therapy with the antibody-like entry inhibitor eCD4-Ig can protect infants from immunodeficiency virus acquisition and treat an established infection. If successful, the proposed research will establish the pre-clinical foundation for using gene therapy as prophylaxis and therapy for perinatal HIV infection.

PI_NAMEs: MARTINS, MAURICIO DE AGUIAR (contact)

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: 2 year old;Address;adeno-associated viral vector;adenovirus mediated delivery;Adherence;Adult;Animals;antenatal;Antibodies;antibody detection;antiretroviral therapy;Binding;Birth;Blood Chemical Analysis;Breastfed infant;Caring;CCR5 gene;Cell Count;Cells;Child;Childhood;Chronic Phase;Circulation;combat;CXCR4 gene;Data;Dependovirus;Early treatment;env Gene Products;experience;experimental study;Foundations;gene product;gene therapy;Gene Transfer;Healthcare;HIV;HIV Entry Inhibitors;HIV Infections;HIV-1;HIV-2;HIV/AIDS;Human;Human Milk;Immune;Immunity;immunodeficiency;immunogenicity;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulins;immunological intervention;in vivo;Infant;Infant Health;infant infection;Infection;Infrastructure;Ingestion;inhibitor;interest;Interphase Cell;Intervention;Kinetics;Licensing;low income country;Macaca mulatta;mature animal;Mediating;Modeling;Monitor;Monkeys;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Mothers;Neonatal;neonatal period;neonate;Newborn Infant;Oral;Pathogenicity;pediatric human immunodeficiency virus infection;peptidomimetics;perinatal HIV;Pharmaceutical Preparations;placebo group;Placebos;postnatal;Postpartum Period;pre-clinical;Predisposition;prenatal;prevent;Prevention;Primate Lentiviruses;programs;Property;prophylactic;Prophylactic treatment;receptor;Reporting;Reproducibility;Research;Resource-limited setting;Safety;Serum;simian human immunodeficiency virus;SIV;Skeletal Muscle;Testing;therapy resistant;transgene expression;Transgenes;transmission process;Treatment-related toxicity;Vaccines;Vertical Disease Transmission;Viral;Viremia;virtual;Virus;Virus Diseases;Virus Replication;Weight Gain

PROJECT_TITLE: AAV-mediated delivery of eCD4-Ig for prevention and treatment of perinatal HIV infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative – OVERALL We propose the first Center for Perioperative Mental Health. We will focus on improving the mental healthcare of older adults undergoing surgery and other invasive procedures. The integration of mental healthcare into perioperative care could improve depression, anxiety, and quality of life. This Center has the potential for substantial public health impact by revolutionizing the approach to perioperative care, based on firm evidence and clinical translation.

PI_NAMEs: AVIDAN, MICHAEL SIMON;LENZE, ERIC J (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Acceleration;Address;anti-depressive agents;Anxiety;anxiety symptoms;Area;Behavior Therapy;Behavioral;Benzodiazepines;brain health;Cardiac Surgery procedures;Caring;Clinical;clinical translation;Cognitive;Cognitive Therapy;Collaborations;Communication;Complex;Delirium;depressive symptoms;Dose;Effectiveness;effectiveness testing;effectiveness/implementation trial;Electronic Health Record;Emotional;evidence base;experience;falls;flexibility;follower of religion Jewish;Health;Health Personnel;Healthcare;Heterogeneity;hospital readmission;Hospitalization;Hospitals;Hybrids;Impairment;implementation evaluation;implementation outcomes;implementation science;implementation strategy;improved;Individual;individual patient;Informatics;Infrastructure;innovation;Intensive Care;interest;International;Intervention;Leadership;Length of Stay;long term recovery;medical complication;Medicine;Mental Depression;Mental Health;Mental Health Services;Mentors;Methodology;Methods;Modeling;multidisciplinary;Needs Assessment;older adult;operation;Operative Surgical Procedures;opioid misuse;Orthopedic Surgery;Outcome;Patients;Perioperative;Perioperative Care;personalized medicine;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phase;physical conditioning;Population;Postoperative Period;postoperative recovery;pragmatic intervention;pragmatic trial;preference;prevent;Procedures;provider communication;Psyche structure;Public Health;Quality of life;Randomized;Readiness;Recovery;Recovery of Function;Rehabilitation therapy;Research;Research Design;Research Personnel;resilience;Resources;Risk;Science;Scientist;Social outcome;Social Well-Being;Speed;Statistical Data Interpretation;Structure;success;Surgical Oncology;Telephone;Testing;Training;treatment as usual;Treatment Effectiveness;treatment planning;Universities;Vision;Washington;World Health Organization

PROJECT_TITLE: Center for Perioperative Mental Health


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Stomach Cancer

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative These studies will define mechanisms and identify people who are at greatest risk for gastric cancer, which will greatly improve the diagnosis and management of this disease.

PI_NAMEs: FOX, JAMES G;PEEK, RICHARD M. (contact)

PROGRAM_OFFICER_NAME: GEORGE, CHRISTINA DAWN

PROJECT_TERMS: Acceleration;Address;Adenocarcinoma;Affect;Antibiotic Therapy;Antibiotics;Atrophic Gastritis;Attenuated;Bacteria;Biological Models;Cancer Etiology;cancer risk;carcinogenesis;Carcinogenesis Mechanism;carcinogenicity;Cells;Cessation of life;Chromosomal Instability;Chronic;Clinical;Clinical Data;clinical investigation;co-infection;cohort;Colombia;Colombian;Complement;Complex;Data;Death Rate;Development;Diagnosis;Disease;Disease Management;Disease Progression;disorder risk;DNA;dysbiosis;Dysplasia;Etiology;Female;follow-up;Freezing;Gases;Gastric Adenocarcinoma;gastric carcinogenesis;Gastric Intestinal Type Adenocarcinoma;Gastric Intraepithelial Neoplasia;gastric microbiota;gastric organoids;Gastric Tissue;Gastritis;Germ-Free;Helicobacter Infections;Helicobacter pylori;high risk;high risk population;High-Risk Cancer;Hispanic;Histologic;Histology;Human;Immune response;immunoregulation;improved;in vivo;Incidence;Individual;Inflammatory Response;Injury;innovation;Intestinal Metaplasia;Intestines;Laboratories;Lesion;Link;Macrophage;male;Malignant - descriptor;Malignant Neoplasms;malignant stomach neoplasm;Mediating;member;metabolomics;metagenome;microbial;microbial community;microbiota;Modeling;Mus;Neoplasms;novel;Oncogenic;pathogen;Patients;Persons;Population;premalignant;prospective;Publishing;Resources;response;Risk;Rodent Model;Seasons;Section 8;Shotgun Sequencing;Shotguns;Signal Transduction;Stomach;Structure;synergism;System;T-Lymphocyte;targeted treatment;Testing;Time;Transplantation;United States;Virulence

PROJECT_TITLE: Interactions Between the Microbiota and Helicobacter pylori in Gastric Carcinogenesis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Mental Health

PHR: Project Narrative – ADMINISTRATIVE CORE The Administrative Core for the Center of Perioperative Mental Health will develop strategies and tactics to inform both the overarching directions of the Center as well as specific important decisions. The Administrative Core will coordinate the various components of the Center to ensure progress and impact. This Core will provide intellectual and logistical support to the investigators and to the extended members of the research team. The Core’s leaders will ensure that all the projects are complementary and synergize with each other and with the cores of the Center.

PI_NAMEs: LENZE, ERIC J (contact)

PROJECT_TERMS: Acceleration;Anesthesiology;Area;brain health;care systems;Clinical Sciences;Collaborations;Communication;Communities;Country;Development;Discipline of Nursing;Disease remission;Dissemination and Implementation;Elderly;Ensure;Environment;experience;Feedback;follower of religion Jewish;Future;Goals;Health Sciences;Healthcare Systems;Hepatobiliary;Hospitals;implementation research;implementation science;Informatics;Infrastructure;Institution;Intervention;investigator training;Investments;Knowledge;Lead;Leadership;medical schools;meetings;member;Mental Health;Mentorship;Methodology;Mind;Mission;multidisciplinary;Needs Assessment;Nutritionist;Oncologist;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Otolaryngology;Pain;Patient Care;Patients;Perioperative;Perioperative Care;Pharmacists;physical therapist;Pilot Projects;Play;population health;post-doctoral training;Principal Investigator;Process;professor;programs;Psychiatry;Records;Research;Research Institute;Research Methodology;Research Personnel;Resources;Role;School Nursing;Scientist;shared decision making;skills;Social Workers;Strategic Planning;success;Surgeon;synergism;Technology;Testing;Thoracic Surgeon;Training;Training Programs;Training Support;Translational Research;Universities;Vision;Washington;Work

PROJECT_TITLE: Administrative Core