NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Methamphetamine;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHOLOGY

PHR: Project Narrative Polysubstance use of fentanyl and methamphetamine is increasingly common and associated with substantial morbidity and mortality, yet vastly understudied. The proposed research will use animal models of polysubstance use that mimic patterns of drug use in humans to examine the striatal neural mechanisms that underlie addiction- related behaviors. This work is significant as it will let us identify what neural cells and adaptations may be particularly relevant targets for therapies aimed at addressing polysubstance use and addiction.

PI_NAMEs: FERGUSON, SUSAN MARIE (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: addiction;Address;Animal Model;Behavior;Behavioral;behavioral economics;Biosensor;Brain;Calcium;cell type;Cells;Consumption;Corpus striatum structure;Cues;design;designer receptors exclusively activated by designer drugs;Development;Dopamine;drug seeking behavior;Drug usage;Electrophysiology (science);Extinction;Fentanyl;fentanyl self-administration;fentanyl use;Fiber;Foundations;Ganglia;Genetic;genetic manipulation;glutamatergic signaling;Glutamates;Health;Heroin;HIV Infections;Human;Image;in vivo;Maps;Methamphetamine;methamphetamine use;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;neural;neural circuit;neuroadaptation;neuromechanism;Neurons;neurotransmission;Nucleus Accumbens;Opioid;Outcome;Overdose;Pattern;Pharmaceutical Preparations;Photometry;polysubstance use;Population;Prefrontal Cortex;Rattus;Research;Risk;Role;Self Administration;Slice;Stimulant;substance use;Synapses;Synaptic Transmission;targeted treatment;Testing;Thalamic structure;Therapeutic Intervention;Time;time use;Treatment outcome;Ventral Tegmental Area;Withdrawal;Work

PROJECT_TITLE: Assessing the role of corticostriatal circuitry in polysubstance use of fentanyl and methamphetamine using rat self-administration models


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE PUBLIC HEALTH RELEVANCE: Basic and clinical research can be expected to have a dramatic and constructive impact on visual disabilities. The Vision Training Grant at the University of Washington supports research and education of young scientists who will make the next generation of advances to conquer biomedical problems in vision and ophthalmology. The opportunities for vision training at the University of Washington are multidisciplinary and cover a broad spectrum of disciplines from cellular and molecular biology to systems biology, visual perception and computational neuroscience and we welcome the opportunity to contribute new solutions to help decrease blindness and morbidity in the world.

PI_NAMEs: BAIR, WYETH DANIEL;PASUPATHY, ANITHA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Grant;Training;Vision

PROJECT_TITLE: Vision Training Grant


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We propose a novel 3D cine MR Fingerprinting exam for comprehensive characterization of cardiomyopathy phenotypes, with prospective validation in patients. This research will streamline MRI exams, reduce operator dependence, and provide reproducible quantitative tools for rapid and objective diagnosis of cardiomyopathies.

PI_NAMEs: HAMILTON, JESSE IAN;RASHID, IMRAN  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TITLE: 3D Cine Magnetic Resonance Fingerprinting for Rapid Phenotyping of Cardiomyopathy

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: MD

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NASHVILLE

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: The RCMI Program in Health Disparities Research is designed to address health disparities through research in diseases that affect the community it serves, engagement of this community in its solutions, and creating technologies and research infrastructure to serve the institutional scientific community and its academic and community partners. This collaborative approach is of vital importance because finding the right answers to address disparities in health equity involves all of us.

PI_NAMEs: ADUNYAH, SAMUEL EVANS (contact);HILDRETH, JAMES E

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Address;Affect;African American Women;Area;Basic Science;Behavioral;Behavioral Research;Bioinformatics;Biological;Biometry;black women;career;Caring;Clinical Research;Collaborations;collaborative approach;Communities;community engagement;community organizations;community partners;CRISPR/Cas technology;Data Science;Dental;design;Development;Disease;Disparity;Environment;environmental enrichment for laboratory animals;Extramural Activities;Funding;Genomics;Goals;Health Disparities Research;health disparity;health disparity populations;health equity;HIV-1 integrase;Human;improved;innovation;Institution;Integrase Inhibitors;interdisciplinary approach;medical schools;Mentorship;Minority;minority health;neuropsychiatry;outcome disparities;Perception;perinatal outcomes;Pilot Projects;Population;population based;programs;Proteins;Provider;Public Health Informatics;racial disparity;Reduce health disparities;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Risk Factors;Scientist;Services;success;Survivors;Technology;tissue culture;Training Support;Trauma;Violence

PROJECT_TITLE: The RCMI Program in Health Disparities Research at Meharry Medical College


ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Atherosclerosis is an inflammatory disease, occurring preferentially in arterial branch points exposed to pro- atherogenic unstable blood flow while the straight parts of arteries exposed to uni-directional athero-protective stable blood flow are spared. Here, we propose a novel hypothesis that atheroprotective stable flow stimulates expression of HEG1 in endothelial cells, which in turn inhibits endothelial inflammation and protects endothelial barrier function, preventing atherosclerosis development. Our study purports that HEG1 is a novel flow sensor (mechanosensor), which plays a key role in atherosclerosis development and is a novel therapeutic target in prevention and treatment of atherosclerosis.

PI_NAMEs: JO, HANJOONG  (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Acute;Antibodies;Aorta;Arteries;ATAC-seq;atheroprotective;Atherosclerosis;Biology;Blood flow;Blood Vessels;Calcium;cardiogenesis;Cardiomegaly;Cardiovascular system;Carotid Arteries;Cause of Death;CCM1 gene;Cell Physiology;Cells;Chromatin;Chronic;chronic inflammatory disease;clinically significant;Coronary artery;Cytoplasm;Data;Dependence;Development;Disease;EGF gene;EGF-Like Domain;Endothelial Cells;endothelial dysfunction;Endothelium;Exposure to;Extracellular Structure;Functional disorder;Genes;Glass;Glycocalyx;glycosylation;Heart;Hour;Human;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Integral Membrane Protein;Intercellular Junctions;knock-down;Knock-out;Knockout Mice;Ligation;magnetic beads;Mediating;Mesenchymal;Modeling;Modification;Monoclonal Antibodies;Mus;Mutagenesis;mutant;Myocardial Infarction;N-terminal;new therapeutic target;novel;novel therapeutic intervention;overexpression;Oxidation-Reduction;Permeability;Phenotype;Play;prevent;Prevention;Process;Proteins;Regulation;release of sequestered calcium ion into cytoplasm;response;Role;sensor;shear stress;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Small Interfering RNA;Stains;Stroke;Structure;Testing;transcriptome sequencing;Transfection;Transmembrane Domain;ultrasound;Untranslated RNA;Validation;validation studies;vector;western diet;Zebrafish

PROJECT_TITLE: HEG1 in endothelial function and atherosclerosis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: ADUNYAH, SAMUEL EVANS (contact)

PROJECT_TERMS: Achievement;Administrative Efficiency;Advisory Committees;Biomedical Research;Budgets;career;career development;Collaborations;Communication;Ensure;Evaluation;experience;Faculty;follow-up;Funding;Goals;Grant;Health Disparities Research;health disparity;improved;innovation;Institution;Leadership;Logistics;medical schools;meetings;Monitor;National Institute on Minority Health and Health Disparities;Office Management;Outcome;Output;Police;Postdoctoral Fellow;Productivity;programs;Qualifying;Recommendation;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Schedule;Schools;Scientist;Secure;Self-Examination;Services;Time;United States National Institutes of Health;Work

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Immunization;Immunotherapy;Prevention;Radiation Oncology;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: Narrative It is very difficult to make drugs to intracellular, cancer specific targets. We propose to create new antibody-based immunotherapies that recognize the antigen targets from intracellular, tumor specific and oncogenic proteins. We will combine these with potent cellular therapies that are emerging as effective therapies for cancer, but are still toxic and not tumor specific.

PI_NAMEs: SCHEINBERG, DAVID A (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acute leukemia;Address;Affect;Alpha Particles;Antibodies;Antibody Therapy;Antigen Presentation;Antigen Targeting;Biochemical;Biology;Biophysics;Bite;cancer cell;cancer therapy;Cell Therapy;Cells;Clinical Trials;design;effective therapy;Epitopes;experimental study;Generations;Genetic;Goals;Human;Immune system;Immunologics;Immunology;Immunotherapy;in vivo;innovation;Isotopes;Learning;Legal patent;Light;Malignant Neoplasms;Molecular;Monoclonal Antibodies;Mus;Mutate;Oncogenic;particle therapy;peptide structure;Pharmaceutical Preparations;predictive tools;Proteins;Proteomics;Research;resistance mechanism;Specificity;System;T-Lymphocyte;Technology;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutically effective;tool;Toxic effect;tumor;Vaccines;Viral;Work;WT1 gene

PROJECT_TITLE: Understanding and Mimicking TCR Recognition with Therapeutic Monoclonal Antibodies.


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Comparative Effectiveness Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

PHR: One in four women experience sexual, physical violence and/or stalking by an intimate partner. Black women are disproportionately affected by intimate partner violence (IPV) and the debilitating symptoms of trauma associated with IPV. In this IPV-focused proposal we seek to adapt, implement, and test an IPV intervention using trauma-informed care practices for Black women in central Tennessee.

PI_NAMEs: SANDERSON, MAUREEN  (contact)

PROJECT_TERMS: Address;Adopted;Affect;American;Attention;Attitude;Black race;black women;care providers;care systems;Caring;Cessation of life;Climate;Clinic;college;community engaged research;community engagement;Coupled;debilitating symptom;Development;Discipline of obstetrics;Disproportionately impacts women;Early Diagnosis;Effectiveness;effectiveness evaluation;efficacy evaluation;Emergency Situation;Ensure;Environment;Evaluation;evidence base;Evidence based practice;experience;Gender;gender disparity;Goals;Gynecology;Health;health care settings;Health Disparities Research;health equity;Health Personnel;Health Services;High Risk Woman;Historically Black Colleges and Universities;HIV;Home;Homicide;implementation science;improved;income disparities;Injury;innovation;intersectionality;Intervention;intimate partner violence;Irregular Menstruation;Knowledge;Learning;Life;male;Measures;Medical;Medical Care Costs;medical schools;Mental Health;Mental Health Associations;Mental Health Services;Methods;Minority;Mission;Modeling;multi-racial;Murder;novel;Outcome;Patient-Focused Outcomes;Patients;Perception;physical conditioning;Play;Positioning Attribute;pragmatic trial;Prevalence;prevention service;primary care clinic;primary outcome;programs;prospective;Provider;psychologic;psychological trauma;Race;racial disparity;racial minority;Recommendation;Reporting;Research;resilience;Resources;Risk;Role;routine screening;screening;screening, brief intervention, referral, and treatment;secondary outcome;Self Efficacy;Services;Stigmatization;Survivors;System;Tennessee;Testing;therapy design;Time;Training;Trauma;trauma symptom;treatment as usual;trial design;Trust;Violence;White Women;Woman;women patients;Women's Health

PROJECT_TITLE: Assessment of Survivor and Provider Perception of Trauma and Violence Informed Care Among Black Women (ASAP-TVIC in Black Women)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: A major goal of modern science is to translate laboratory findings into improved diagnosis and treatment of human diseases. The Training Program in Molecular Medicine is designed to train young scientists to accomplish this task with a specifically designed curriculum, training in outstanding laboratories, and including direct interactions with practicing clinicians.

PI_NAMEs: SMITH, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: Molecular Medicine Training Program at Cleveland Clinic/Case Western Reserve University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Diabetes;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Substance Misuse;Women's Health Research

PHR: RELEVANCE NARRATIVE Our observational study will monitor and evaluate a cohort of pregnant African American women to better understand the correlation between environmental stressors (i.e., demographics, socioeconomic, and psychosocial factors) and poor sleep quality that we postulate portends adverse pregnancy outcomes (APO) more prevalent in African American women compared to Caucasian women. We expect to uncover new risk factors predisposing African American women to APO. This information will help guide the development of preventive and management strategies for curtailment of racial disparities in APO.

PI_NAMEs: CHIRWA, SANIKA SAMUEL (contact)

PROJECT_TERMS: actigraphy;adverse pregnancy outcome;Affect;African American;African American population;African American Women;Age;American;Amino Acids;Attention;Biochemical;biological adaptation to stress;Biological Assay;Biological Markers;Blood specimen;C-reactive protein;Carrier Proteins;Caucasians;Chronic stress;clinical biomarkers;cohort;coping;corticotropin releasing factor-binding protein;Corticotropin-Releasing Hormone;cortisol binding globulin;Coupled;Death Rate;demographics;Development;Disparity;Early Diagnosis;Education;Enrollment;Environmental Impact;environmental stressor;Evaluation;evidence base;Fetal Growth Retardation;Gestational Diabetes;Glucose;Glucose Intolerance;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Health Disparities Research;health equity;Health Policy;Health Services;Health Status;Hemorrhage;hormone binding protein;Hormones;Hour;Hydrocortisone;Hyperglycemia;impaired glucose tolerance;Incidence;Infant;innovation;insight;Institution;Insulin;Insulin Resistance;Knowledge;Leadership;Link;Lipids;Low Birth Weight Infant;low socioeconomic status;Maternal Mortality;Measures;Medical;medical schools;Metabolic;Metabolic Diseases;Metabolism;Mission;Monitor;Neonatal Mortality;non-drug;novel;Nutrient;nutrition;Obesity;Observational Study;OGTT;Participant;perinatal outcomes;physical inactivity;Physiological;Pilot Projects;poor sleep;Pre-Eclampsia;Predisposing Factor;Pregnancy;pregnant;Pregnant Women;Premature Birth;Preventive;programs;psychosocial;Psychosocial Factor;Psychosocial Stress;racial disparity;Regulation;Research;response;Risk;Risk Factors;saliva sample;screening;Sleep;Sleep Fragmentations;sleep onset;sleep quality;Societies;Socioeconomic Factors;Socioeconomic Status;socioeconomics;stillbirth;Stress;stress reduction;stressor;Test Result;Testing;unconscious bias;Validation;White Women;Woman

PROJECT_TITLE: RISK FACTORS FOR RACIAL DISPARITIES IN ADVERSE PERINATAL OUTCOMES AFFECTING AFRICAN AMERICAN WOMEN


NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Patient Safety;Social Determinants of Health;Substance Misuse

PHR: PROJECT NARRATIVE  HIV-1 integrase strand transfer inhibitors (INSTIs) are among the most widely prescribed antiretrovirals. The goal of this application is to dissect the mechanism of INSTI--associated neuropsychiatric adverse effects. Our studies will generate new knowledge to promote novel strategies to prevent and/or manage INSTI- associated neuropsychiatric complications among people living with HIV.

PI_NAMEs: PANDHARE, JUI  (contact)

PROJECT_TERMS: Adverse effects;Adverse event;Affect;African American population;Anti-Retroviral Agents;antiretroviral therapy;Biochemical;Biochemical Pathway;Brain;Brain region;Calcium;Calcium Channel;Calcium Signaling;Chromosomes;Clinical;Clinical Research;clinically relevant;Cognitive deficits;Communication;Data;Disease;DNA Integration;Drug usage;effective therapy;Electrophysiology (science);Equilibrium;excitotoxicity;Exposure to;extracellular;Functional disorder;Genetic;Genetic study;Genome;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Health Disparities Research;HIV;HIV Infections;HIV-1;HIV-1 integrase;HIV/AIDS;Homeostasis;in vivo;Individual;Induced Neurons;Infection;inhibitor;Integrase;Integrase Inhibitors;interdisciplinary approach;Knowledge;Length;Measures;Mediating;medical schools;Metabolic;Minority;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurites;Neuronal Dysfunction;Neurons;Neuropathogenesis;neuropsychiatric disorder;neuropsychiatry;Neurosciences;neurotransmission;novel;novel strategies;Nucleus Accumbens;Pathway interactions;Persons;Pharmacology Study;Play;postsynaptic;presynaptic;prevent;Production;programs;Recommendation;Regimen;Reporting;Research;response;reward circuitry;Role;side effect;Signal Transduction;success;Synapses;synaptic function;Testing;Up-Regulation;viral DNA;Virus;voltage

PROJECT_TITLE: Examining the neuropsychiatric effects of HIV-1 integrase inhibitors


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Dissemination and Implementation Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Breastfeeding and skin-to-skin care are known to improve outcomes of opioid-exposed infants; however, these maternal-delivered care practices are not broadly implemented. This study will develop an implementation strategy, tailored to the characteristics and needs of opioid-exposed mothers and infants, to improve implementation of breastfeeding and skin-to-skin care and inform practice and policy.

PI_NAMEs: SHUMAN, CLAYTON JOHN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Adoption;Affect;Agreement;Award;Breast Feeding;care delivery;care outcomes;career development;Caring;Characteristics;Clinical Treatment;Clinical Trials;Collection;Complement;Complex;complex data;Conduct Clinical Trials;Consolidated Framework for Implementation Research;contextual factors;cost;cost estimate;COVID-19 pandemic;dalton;Data;Data Collection;Data Set;demographics;design;Diagnosis;drug withdrawal;Eating;Effectiveness;Eligibility Determination;evidence base;Evidence based intervention;Expenditure;experience;Exposure to;Future;Goals;Health;Health Services Research;Helping to End Addiction Long-term;high risk infant;Hospital Costs;Hospital Units;Hospitalization;Hospitals;implementation determinants;implementation efforts;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Infant;innovation;Interview;Investments;Knowledge;Leadership;Length;Length of Stay;Link;long-term sequelae;Maps;Maternal Exposure;Medical Records;Medicine;Mentors;Mentorship;Methodology;Methods;Mothers;National Institute of Child Health and Human Development;Neonatal;Neonatal Abstinence Syndrome;neonatal care;Neonatal Intensive Care Units;neonatal outcome;Newborn Infant;Nonpharmacologic Therapy;novel;Nurse's Role;opioid epidemic;opioid exposure;opioid overdose;opioid use;opioid withdrawal;Outcome;Perinatal;perinatal health;Pharmaceutical Preparations;Pharmacological Treatment;Pilot Projects;Policies;Postpartum Period;programs;Public Health;Randomized, Controlled Trials;Recovery;recruit;Reporting;Research;research and development;Research Personnel;Research Proposals;Role;routine care;Scientist;Severities;skills;Skin;Skin Care;Sleep;Structure;substance use;success;Surveys;Techniques;Testing;theories;Training;United States National Institutes of Health;Weaning;Withdrawal Symptom;Woman

PROJECT_TITLE: Mom is medicine: Implementing maternal-delivered nonpharmacologic care for neonatal opioid withdrawal

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: MILLER-HUGHES, STEPHANIA T. (contact)

PROJECT_TERMS: Acceleration;Address;African American population;Cessation of life;Chronic Disease;Collaborations;Communities;community academic partnership;community advisory board;community collaboration;community engaged research;community engagement;Community Health;community organizations;Community Participation;community partners;Consensus;COVID-19;COVID-19 burden;COVID-19 complications;COVID-19 intervention;COVID-19 pandemic;COVID-19 prevention;Databases;Development;Disparity;Employment;Enrollment;ethnic health disparity;ethnic minority;Evaluation;experience;Feedback;Fostering;Goals;Grant;Health;Health Disparities Research;health disparity;Hispanic Populations;improved;Information Dissemination;Infrastructure;Institution;interest;Intervention Studies;Measures;medical schools;member;Morbidity - disease rate;mortality;Nature;Newsletter;Organization administrative structures;Outcome;Participant;Phase;Pilot Projects;Prevention;Procedures;Process;programs;racial disparity;racial health disparity;racial minority;Ramp;recruit;Registries;Research;research data dissemination;Research Personnel;Research Priority;Resources;Rights;Role;service delivery;sharing platform;Site;Social Marketing;Students;System;Testing;Time;Training;Training Activity;Translating;Translational Research;Translations;trend;Vaccine Clinical Trial;Work;working group

PROJECT_TITLE: Community Engagement Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: MISCELLANEOUS

PHR: NARRATIVE Hematopoietic stem cells (HSCs) execute fate decisions to produce different blood cell lineages, a process which is perturbed in myelodysplastic syndromes (MDS). We propose to study how lamin B1 organizes the genome in 3-dimensions inside the nucleus in order to regulate HSC fate decisions, and how deletions of the lamin B1 gene contribute to MDS pathogenesis.

PI_NAMEs: DOULATOV, SERGEI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3-Dimensional;Abnormal Neutrophil;Aging;Architecture;Bar Codes;Binding;Biology;Blood;Blood Cells;Body System;cell fate specification;Cell Lineage;Cell Nucleus;Cells;Chromatin;Chromatin Loop;chromosome 5q loss;Chromosomes;Clonal Expansion;Collaborations;Computer Analysis;Development;Disease;disease model;Distal;Dysmyelopoietic Syndromes;Elements;Enhancers;Equilibrium;Euchromatin;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genome;Health;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic stem cells;high risk;Human;Impairment;in vivo;induced pluripotent stem cell;Inherited;lamin B receptor;Lamin B1;Lamins;Lymphoid;Lymphopoiesis;Molecular;Morphology;Mutation;Myelogenous;Myeloid Cells;Nuclear;Nuclear Lamin;Pathogenesis;Pelger-Huet Anomaly;pharmacologic;Phenocopy;Play;premalignant;Process;Production;programs;promoter;Proteins;Recurrence;Regulation;Role;self-renewal;Somatic Mutation;Specific qualifier value;stem;stem cell fate specification;stem cell function;stem cell model;stem cells;Structural Protein;Testing;Therapeutic;Three-dimensional analysis;transcription factor;Tumor Suppressor Proteins;Work

PROJECT_TITLE: The role of lamin B1 in normal and myelodysplastic hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


PI_NAMEs: VILLALTA, FERNANDO  (contact)

PROJECT_TERMS: Address;Applications Grants;Award;Basic Science;Behavioral Research;Biomedical Research;career;career development;Clinical Research;Communities;Data Science;data submission;Development;Disease;Disparity population;Extramural Activities;Faculty;Funding;Goals;Grant;Health Disparities Research;health disparity;innovation;Leadership;Link;medical schools;Mentors;Minority;next generation;Outcome;Outcomes Research;Participant;Pilot Projects;Postdoctoral Fellow;programs;Publications;Research;Research Personnel;Resource Development;success;Technology;timeline;United States National Institutes of Health

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Aging is a universal and potent risk factor for heart disease. Blood vessels stiffen with age in both men and women with women’s arteries stiffening later in life, faster, and with significantly worse outcomes than men. We discovered that the receptor for estrogen, located on the blood vessel, plays a role in aging-associated blood vessel stiffness. This proposal will determine how blood vessel stiffening differs between men and women with age and how the female sex hormone estrogen and its receptor may contribute to this process. These studies will identify sex-specific therapies to improve cardiovascular outcomes with aging.

PI_NAMEs: DUPONT, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Age;aged;Aging;aging population;aging related;Agonist;Aorta;arm;arterial stiffness;Atomic Force Microscopy;Attenuated;Bilateral;Binding;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;chromatin immunoprecipitation;Chronic;Clinical;clinically significant;Data;Development;Disease Outcome;EFRAC;Elderly;ESR1 gene;Estrogen decline;Estrogens;experience;Female;female sex hormone;Fibrosis;gene repression;Goals;Health;Heart Diseases;Heart failure;Hormone replacement therapy;Human;human female;Hypertension;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;Isolated systolic hypertension;Knockout Mice;Knowledge;Life;Ligands;male;Measures;Mediating;Medical;men;middle age;Midlife women;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;new therapeutic target;novel;Organ;Outcome;Ovariectomy;Pathway interactions;Pattern;Pharmaceutical Preparations;Physiologic pulse;Play;Poly(ADP-ribose) Polymerases;Population;Postmenopause;Premenopause;preservation;prevent;Procedures;Process;promoter;Public Health;receptor;Receptor Activation;receptor expression;receptor function;Receptor Signaling;Regulation;Renin-Angiotensin-Aldosterone System;Risk;Risk Factors;Role;sex;Sex Differences;sexual dimorphism;Small Interfering RNA;Smooth Muscle Myocytes;Stroke;Testing;therapeutic evaluation;therapeutic target;Tissues;treatment group;Type 2 Angiotensin II Receptor;Vascular Smooth Muscle;Woman;women versus men

PROJECT_TITLE: The sexually dimorphic role of smooth muscle cell estrogen receptor alpha in vascular aging


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);HIV/AIDS;Social Determinants of Health;Substance Misuse

PHR: Meharry RCMI Research Capacity Core has one overarching goal and that is to increase the number of investigator-initiated research grants from extramural sources. To achieve this goal, we will introduce new cores, purchase more equipment with institutional funds, recruit two more staff scientists, and enhance our cost recovery efforts to sustain the core.

PI_NAMEs: OCHIENG, JOSIAH  (contact)

PROJECT_TERMS: Affect;Applications Grants;Award;Basic Science;Biomedical Research;Budgets;Businesses;Cardiovascular system;Cells;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Communities;Computational Science;Consultations;cost;CRISPR/Cas technology;Data;data access;Data Analyses;data mining;Databases;design;Development;Diabetes Mellitus;Disease;Doctor of Philosophy;Electron Microscope;Equipment;Experimental Designs;Extramural Activities;foot;Fostering;Funding;Genes;genomic data;Genomics;Genus Hippocampus;Goals;Grant;Health Disparities Research;HIV/AIDS;Image;improved;Income;Individual;Infection;Information Technology;Infrastructure;Institution;instrumentation;Investigator-Initiated Research;Journals;Laboratories;Letters;Malignant Neoplasms;Manuscripts;medical schools;metabolomics;next generation sequencing;operation;Outcome;people of color;programs;protein protein interaction;Protocols documentation;Publishing;Recovery;recruit;Research;Research Personnel;Research Project Grants;Resources;Schools;Scientist;service delivery;Services;Source;success;Surveys;System;Talents;Time;Training;Transfection;Translational Research;Universities;Visualization

PROJECT_TITLE: Research Capacity Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The overall goals of this longitudinal study are to identify diagnostic neural biomarkers of anxiety in adolescence; determine the effects of environmental exposures, including COVID-19 pandemic-related stressors, on anxiety-relevant neural biomarkers; characterize pre-pandemic neural, physiological, behavioral, and environmental factors that increase risk for adolescent anxiety in response to pandemic-related stressors; and develop composite profiles of neural, physiological, behavioral, physiological, and environmental characteristics from infancy through adolescence that robustly predict anxiety across development. The findings will enhance our understanding of the etiology of anxiety in youth, with a focus on adolescence, a core risk period for the development or exacerbation of anxiety. This knowledge is expected to inform the development of novel strategies to identify and treat youth at risk for anxiety difficulties prior to the emergence of clinical pathology and to characterize new targets for intervention for youth experiencing symptoms.

PI_NAMEs: BOSQUET ENLOW, MICHELLE A (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 13 year old;7 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;Anger;Anxiety;Anxiety Disorders;attentional bias;Autonomic nervous system;Behavior;Behavioral;Biological Assay;Biological Markers;brain based;Brain region;bullying;caregiving;Characteristics;Child;Childhood;childhood anxiety;Chronic;Clinical Pathology;cohort;Communities;cost;Coupling;COVID-19;COVID-19 pandemic;Data;Data Set;design;Development;Diagnosis;Diagnostic;early adolescence;early childhood;Economics;Electroencephalography;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;Event;executive function;experience;Exposure to;Face;Family;Family Relationship;Follow-Up Studies;Fright;functional near infrared spectroscopy;Funding;generalized anxiety;Goals;Heterogeneity;Hormonal Change;Human;improved;Individual;infancy;innovation;Intervention;Knowledge;Life;Longitudinal cohort;longitudinal design;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Maintenance;Measures;Mental disorders;middle childhood;Modeling;multimodality;neural;neural circuit;Neurobiology;neurodevelopment;neurophysiology;novel;novel strategies;pandemic stressor;Participant;peer;peer support;person centered;Phase;Phenotype;Phobias;Physiological;Positioning Attribute;pre-pandemic;Predictive Value;Predisposition;prevent;Prevention strategy;Process;Progress Reports;Prospective Studies;Protocols documentation;Psychopathology;Puberty;Research;resilience;Resistance;response;Rest;Risk;Risk Factors;Risk Marker;risk prediction;SARS-CoV-2 exposure;school disruption;Schools;Separation Anxiety;Severities;sex;Sex Differences;social;social anxiety;Social isolation;social media;stress reactivity;stressor;Structure;symptomatology;Symptoms;Temperament;Testing;tool;Youth

PROJECT_TITLE: Neural, Physiological, Behavioral, and Environmental Risk Markers of Anxiety from Infancy to Adolescence

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pregnancy;Social Determinants of Health

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: NARRATIVE (Public Health Relevance) In the United States, children’s development differs markedly as a function of their family’s socioeconomic status (SES). Although risk factors contributing to these disparities have been broadly studied, we have only a superficial understanding of how these factors “get under the skin” to influence biological processes that shape key developmental outcomes like language and cognition. The goal of this proposal is to integrate approaches from the biological and psychological sciences to understand SES disparities in language and cognitive development. Using state-of-the-art methods from across the social and biological sciences, we investigate the contributions of adverse gestational environments and postnatal caregiving environments to SES disparities in language and cognition in the infant-toddler period and at age 5. This research will answer key questions about the origins of SES disparities in developmental outcomes that have important implications for theory, policy, and practice.

PI_NAMEs: PELLERITE, MATTHEW  (contact);WEISLEDER, ADRIANA

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 2 year old;5 year old;Adopted;Age;Animals;autism spectrum disorder;Behavioral Sciences;Biological;Biological Process;Biological Sciences;Blood Vessels;Brain;caregiving;Cerebral Palsy;Characteristics;Child;Child Development;Child Language;Clinical;Cognition;Cognitive;cognitive development;contextual factors;Development;Disadvantaged;Disparity;economic implication;Education;Environment;environmental enrichment for laboratory animals;Exposure to;Family;fetal;Funding;Gene Activation;Gene Expression Profile;Genes;Goals;Growth;Histologic;Histology;Human;immune activation;Immune response;Impaired cognition;Impairment;Individual;Infant;Inflammation;Inflammatory;kindergarten;Language;Language Development;language impairment;Learning;Lesion;Linguistics;Link;Low income;maternal stress;Measures;Mediating;Methods;Micronutrients;Neuronal Injury;Nursery Schools;Outcome;Pathology;perinatal outcomes;Placenta;Policies;postnatal;Poverty;Pregnancy;pregnant;Premature Birth;psychologic;Psychological Factors;Psychological Stress;public health relevance;Research;Risk Factors;Science;Shapes;Skin;social;social implication;Social Sciences;Societies;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Status;Stress;structural determinants;theories;Toddler;Toxic Environmental Substances;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Identifying the contributions of gestational and caregiving environments to socioeconomic disparities in child language and cognitive development.

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: PROJECT NARRATIVE This project seeks to develop a multiplex real time test that can detect both HIV and Hepatitis B infection with a single test. The test will be able to detect types of HIV and Hepatitis B viruses that are unique to Mali and West Africa. The test will also be adapted to the low resources, limited equipment, supplies, and technicians in a low- and middle-income country (LMIC), such as Mali. I want to become a leader in the development of tests to diagnose and monitor infections but are adapted for use in LMICs.

PI_NAMEs: FOFANA, DJENEBA BOCAR (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Adult;Affect;Africa;Africa South of the Sahara;African;American;animation;anti-viral efficacy;Anti-viral resistance;Anti-viral Therapy;antiretroviral therapy;Award;Biological Assay;Biological Testing;Biostatistical Methods;Blood;Blood donor;Budgets;Burkina Faso;career development;Caring;Cessation of life;Child;Chronic Hepatitis B;Cirrhosis;Clinical;Clinical Trials;co-infection;Collaborations;Combined Modality Therapy;Coronavirus;cost;Counseling;Country;course development;Data;design;Development;Diagnosis;Diagnostic tests;Disease;Doctor of Pharmacy;Doctor of Philosophy;Drug resistance;Early Diagnosis;Early treatment;Educational process of instructing;Electricity;emtricitabine;Enterovirus;Environment;Equipment;Evaluation;Face;Fumarates;General Population;genetic variant;Genetic Variation;Genotype;Goals;Health Sciences;Healthcare;Hepatitis B;Hepatitis B Infection;Hepatitis B Surface Antigens;Hepatitis B Virus;Hepatitis C virus;high risk;HIV;HIV anti-retroviral;HIV Infections;HIV-1;HIV/AIDS;Human immunodeficiency virus test;Human Papillomavirus;immunosuppressed;implementation strategy;Individual;Infection;injection drug use;Knowledge;Laboratories;Laboratory Technicians;Lamivudine;Lead;Leadership;Link;Liver;Liver Cirrhosis;Liver diseases;low and middle-income countries;Mali;Measurement;Measures;Medical;Medical Students;Mentors;Methods;Microbiology;mid-career faculty;Molecular;Molecular Biology;Monitor;mortality;novel diagnostics;nucleic acid detection;Nucleic Acids;Paris, France;Patient Monitoring;patient screening;Patients;Performance;Persons;Phase;Play;Population;population based;Population Group;Pregnant Women;Prevalence;Primary carcinoma of the liver cells;Professional Competence;programs;Protocols documentation;Public Health;Reagent;Recommendation;Refrigeration;Regimen;Research;research clinical testing;Resources;Risk;RNA;Role;Science;screening;Serum;skill acquisition;skills;source localization;Students;System;Techniques;Technology;Tenofovir;Testing;Time;tool;tool development;Training;transmission process;Universities;Viral;viral DNA;Viral Load result;virology;Virus Diseases;Virus Replication;World Health Organization

PROJECT_TITLE: Development of a Multiplex Quantitative PCR Assay for HIV and Hepatitis B Virus, for Low- and middle Income Countries

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed study is aimed to test the efficacy and feasibility of using air filtration to ameliorate atherothrombosis progression. This project may have international impact on identifying effective and affordable methods to reduce personal air pollution exposure and prevent cardiovascular disease morbidity and mortality.

PI_NAMEs: CHEN, ZHANGHUA  (contact);ZHANG, JUNFENG

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Adult;Adverse effects;Age;age acceleration;Air;air cleaner;air filtration;air monitoring;Air Pollution;Area;arterial stiffness;Atherosclerosis;atherothrombosis;Biological Markers;Blood coagulation;Blood Glucose;Blood Pressure;burden of illness;C-reactive protein;Calendar;Calibration;California;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cause of Death;Censuses;China;Clinical;Computerized Medical Record;cost;Cross-Over Studies;Cross-Over Trials;Crossover Design;Data;design;Devices;Diabetes Mellitus;Double-Blind Method;efficacy evaluation;efficacy testing;Enrollment;Environmental Risk Factor;epidemiology study;ethnic diversity;Ethnic Origin;Event;experience;Exposure to;feasibility trial;Female;Filtration;fine particles;Future;Goals;Health;Heart failure;high efficiency particulate air filter;Hispanic;Hispanic Populations;Home visitation;improved;In Vitro;in vivo;Incidence;indexing;indoor air;indoor particulate matter;Inflammatory;interest;Interleukin-6;International;Intervention;Intervention Trial;Life;Life Style;Link;Los Angeles;male;Measures;men;meteorological data;Methods;Minority Groups;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;Myocardial Infarction;Myocardial Ischemia;non-smoker;Not Hispanic or Latino;novel;older adult;Older Population;Outcome;P-Selectin;Participant;Particulate;Patients;Persons;Physiologic pulse;Plasma;pollutant;Pollution;Population Heterogeneity;Populations at Risk;portability;Predisposition;prevent;primary outcome;Process;Proteomics;Questionnaires;Randomized;Recording of previous events;Research Design;Research Personnel;residence;response;Risk;Risk Factors;Sampling;secondary outcome;sex;Specific qualifier value;Statistical Data Interpretation;Stroke;Subgroup;Sudden Death;systemic inflammatory response;Teenagers;Thrombosis;Time;treatment arm;trial comparing;United States;United States National Institutes of Health;Universities;University resources;Variant;von Willebrand Factor;Vulnerable Populations;Wildfire;Woman

PROJECT_TITLE: Slowing Atherothrombosis Progression through Indoor Air Filtration: A Crossover Trial in Hispanic and non-Hispanic Adults with Ischemic Heart Disease History

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(91)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Neurosciences;Pediatric

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Vein of Galen aneurysmal malformations (VOGMs) are among the most common and severe congenital anomalies of the human cerebral vasculature, causing sudden catastrophic intracranial hemorrhages that are often lethal despite neurosurgical intervention. We propose to use a multidisciplinary approach that combines cutting-edge, next-generation DNA sequencing and bioinformatics with biochemistry and structural biology to elucidate the genetic architecture and molecular mechanisms of VOGMs. Resulting advances will illuminate critical aspects of human cerebrovascular development and disease pathogenesis; improve clinical prognostication and decision-making; and provide a mechanistic foundation for the rationale use of repurposed drugs and/or design of targeted therapeutics relevant for VOGM and potentially other cerebrovascular lesions.

PI_NAMEs: BOGGON, TITUS JONATHON;KAHLE, KRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: ACVR1 gene;ACVRL1 gene;Address;Antibodies;Arteriovenous malformation;Autopsy;Biochemical;Biochemistry;Bioinformatics;bioinformatics pipeline;Biological;Biological Assay;Biophysics;Blood capillaries;Blood Vessels;brain arteriovenous malformations;Brain Diseases;candidate validation;Cells;Cellular biology;cerebrovascular;cerebrovascular lesion;Cerebrovascular system;Childhood;Clinical;cohort;Complex;congenital anomaly;Cutaneous;Data;de novo mutation;Decision Making;deep sequencing;design;Development;Diagnostic;Disease;Disease Management;DNA Resequencing;DNA sequencing;drug repurposing;Ephrin-B2;Ephrins;exome sequencing;experience;experimental study;Foundations;FRAP1 gene;Functional disorder;functional genomics;Galen Vein;gene discovery;gene function;Gene Mutation;Genes;genetic architecture;Genetic Counseling;genetic pedigree;Genetic study;genome-wide;Genomic approach;Germ Lines;Germ-Line Mutation;Heterogeneity;Human;Human Genetics;improved;in silico;In Vitro;Inherited;insight;interdisciplinary approach;interest;Intervention;Intracranial Aneurysm;Intracranial Hemorrhages;Knowledge;Lesion;Ligands;malformation;Mass Spectrum Analysis;Measures;Molecular;mosaic;mosaic variant;Mosaicism;Mutate;Mutation;Nature;Neurons;neurosurgery;next generation;novel;Ontology;Parents;Pathogenesis;Pathway interactions;Patients;Phenotype;Phosphotransferases;prognostication;protein complex;protein structure;Proteomics;ras GTPase-Activating Proteins;recruit;Resolution;Role;Scheme;segregation;Signal Pathway;Signal Transduction;skin biopsy;Somatic Mutation;spatiotemporal;Specific qualifier value;structural biology;Structure;Syndrome;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;transmission process;Validation;Variant

PROJECT_TITLE: Human Genetics and Molecular Mechanisms of Vein of Galen Aneurysmal Malformation

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE  Alzheimer’s disease (AD) is an irreversible, progressive brain disorder that currently has no cure. We will develop a novel anti-inflammation therapy to treat AD. We expect that successful completion of this project will make a significant impact on the treatments of AD.

PI_NAMEs: WANG, JIN  (contact);ZHENG, HUI

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Acids;Acute;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease therapy;Amides;Amyloid beta-Protein;Animals;Anti-Inflammatory Agents;Arachidonic Acids;Astrocytes;Attenuated;Behavioral;benzimidazole;Binding;Binding Proteins;Biochemical;Biological Assay;Biological Availability;Blood - brain barrier anatomy;Brain;Brain Diseases;Canis familiaris;Cause of Death;Cell Communication;cell type;Cells;Central Nervous System;Central Nervous System Agents;Cerebral Ischemia;chemoproteomics;Clinical;Collaborations;Cytochrome P450;Cytoprotection;Data;Dementia;design;Disease;Disease Progression;Docking;Dose;drug development;drug discovery;Drug Kinetics;efficacy evaluation;Ensure;Enzymes;Epoxide hydrolase;Equilibrium;experience;Functional disorder;Gene Deletion;Half-Life;Impaired cognition;improved;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory Response;inhibitor;Innate Immune Response;Knowledge;Lead;Learning;Legal patent;Maximum Tolerated Dose;Memory impairment;Microglia;Modeling;Molecular;mouse model;Mus;Neuroglia;neuroinflammation;neuroprotection;neurovascular unit;novel;Oral;Parkinsonian Disorders;Pathogenesis;Pathology;Pattern recognition receptor;Penetration;Permeability;Pharmaceutical Chemistry;Pharmacodynamics;pharmacologic;Pharmacology;pharmacophore;Plasma;Play;pre-clinical;Pre-Clinical Model;prevent;Property;protein aggregation;Rattus;Reporting;response;Risk;Roentgen Rays;Role;Safety;scale up;Seizures;Severity of illness;Signal Transduction;small molecule;Structure;success;tau Proteins;Testing;Toxic effect;Toxicology;Traumatic Brain Injury;United States;Urea;virtual screening;Work;X-Ray Crystallography

PROJECT_TITLE: Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: PHARMACOLOGY

PHR: NARRATIVE Immunoglobulin µ (IgM), is a type of antibody integral to the mammalian immune system and is especially critical in the early stages of development. The complexity of IgM has historically made them difficult to study and our current understanding of how IgM functions on a molecular level remains limited. We will apply new techniques to elucidate study the activation of IgM, which will be critical for development of future biotherapies for treatment of cancers, infectious diseases, and autoimmune disorders.

PI_NAMEs: GUTTMAN, MIKLOS  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Antibodies;Antibody Response;Antibody-mediated protection;antigen binding;Antigen Presentation;Antigens;Architecture;arm;Autoimmune Diseases;Binding;Biological Response Modifier Therapy;biophysical tools;cancer therapy;Communicable Diseases;Complement;Complement 1q;Complement Activation;Complement component C1;Complement component C1r;Complement component C1s;complement system;Complex;Cryoelectron Microscopy;density;design;Deuterium;Development;Disease;Electron Microscopy;flexibility;foot;Foundations;Future;glycosylation;Heterogeneity;Hydrogen;Immobilization;Immune system;Immunity;Immunoglobulin G;immunoglobulin structure;Immunoglobulins;immunoregulation;Infection;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Molecular;Molecular Conformation;Monitor;natural antibodies;Outcome;pathogen;Pharmaceutical Preparations;Phase I Clinical Trials;Polymers;Printing;Process;Recombinants;recruit;Refractory;Resolution;response;Roentgen Rays;Scaffolding Protein;Structure;Surface;Techniques;Testing;Therapeutic;timeline;tool;transmission process;tumor;Visualization

PROJECT_TITLE: Mechanisms of IgM mediated activation of the complement system

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Networking and Information Technology R&D (NITRD);Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative High-risk polypharmacy is common among older adults in the United States, is particularly dangerous for individuals with dementia or cognitive impairment, and is associated with harms such as adverse drug reactions, falls, and higher costs of care. This project aims to test in a pragmatic clinic-randomized controlled trial two electronic health record-based behavioral economic nudges to help clinicians reduce high-risk polypharmacy among their older adult patients and in the subgroup with dementia or cognitive impairment. If these nudges prove effective, they could be deployed in other health systems throughout the county to lower the risk for medication-induced harm to older adults.

PI_NAMEs: PERSELL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Academic Detailing;Adult;Adverse drug event;adverse drug reaction;adverse outcome;Affect;Antibiotics;behavioral economics;beneficiary;care costs;Caring;Clinic;Clinical;Clinical Pharmacists;Cognitive;Combination Medication;cost;Country;County;Dangerousness;Data;Decision Making;Dementia;design;discount;Drug Interactions;Education;Effectiveness;Elderly;Electronic Health Record;Environment;Event;experience;falls;Feeling;Funding;Future;health plan;Health system;high risk;human old age (65+);Impaired cognition;improved;Individual;Intervention;Interview;Logic;Measures;Medical;Medicare;medication nonadherence;medication safety;Methods;mild cognitive impairment;Modeling;mortality;multidisciplinary;older adult;Older Population;overtreatment;Paper;Patients;Perception;Persons;Pharmaceutical Preparations;Physicians;pilot test;Polypharmacy;Positioning Attribute;Pragmatic clinical trial;Predisposition;prescription opioid;Prevalence;Prevention;Primary Care;primary care clinic;Primary Care Physician;primary care practice;provider behavior;Public Health Informatics;Randomized;Randomized, Controlled Trials;Reporting;Research;Risk;Running;Rural;Screening procedure;Site;Social Accountability;Specific qualifier value;Structure;Subgroup;suburb;Surveys;System;Techniques;Testing;Thinking;tool;United States;United States National Institutes of Health;uptake;Weight

PROJECT_TITLE: Reducing High Risk Polypharmacy Using Behavioral Economics through Electronic Health Records

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HEIDELBERG

ORG_COUNTRY: GERMANY

ORG_FIPS: GM

ORG_NAME: EUROPEAN MOLECULAR BIOLOGY LABORATORY

PHR: PROJECT NARRATIVE Proteins shape our cells, tissues, and organs in response to the complex interplay of genomics with environmental and developmental cues, and thereby hold the key to understanding how individual genomic variation affects our phenotype, disease susceptibility, and drug responses. UniProt provides a reference resource that efficiently standardizes and organizes knowledge of proteins and their functions in forms that both humans and machines can understand and interpret. The UniProt knowledge framework enables biomedical researchers to rapidly understand what is already known, enabling them to design insightful experiments to understand human disease at a molecular level.

PI_NAMEs: BATEMAN, ALEX  (contact);BRIDGE, ALAN JAMES;WU, CATHY H.

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Acceleration;Affect;Amino Acid Sequence;Artificial Intelligence;biomedical data science;Biomedical Research;biomedical resource;Catalogs;Cells;Collaborations;Communities;Complex;computable knowledge;crowdsourcing;Cues;Data;data access;data reuse;Data Set;deep learning;deep learning model;design;Development;Disease;Disease susceptibility;Distance Learning;Ensure;Environment;experience;experimental study;FAIR principles;formycin triphosphate;genetic architecture;genomic variation;Genomics;Genotype;Glean;Growth;hackathon;Health;Hereditary Disease;Human;human disease;Human Genetics;Human Microbiome;improved;Individual;innovation;International;Internet;Knowledge;knowledge curation;Knowledge Extraction;knowledgebase;learning engagement;Literature;Machine Learning;machine learning method;macromolecular assembly;meetings;Methods;Modernization;Molecular;Molecular Biology;Molecular Sequence Data;Molecular Structure;new technology;Ontology;Organ;Orthologous Gene;Outcome;Paper;pathogen;Pathway interactions;Pattern;personalized diagnostics;Pharmaceutical Preparations;Phenotype;Play;Process;Production;prognostic;Protein Array;protein function;Proteins;Publications;Readability;Readiness;Research;Research Personnel;Resources;response;Role;Science;Shapes;Site;social media;Standardization;Structure;symposium;System;Technology;text searching;Tissues;Training;training data;Triage;Variant;web site;webinar;Work

PROJECT_TITLE: UniProt: A Protein Sequence and Function Resource for Biomedical Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Clonal hematopoiesis (CH), i.e. the presence of clonally expanded hematopoietic cells in the bone marrow and blood of healthy individuals, is now recognized as a near-universal phenomenon that predisposes to myeloid malignancies and offers an opportunity to understand the initiating processes of oncogenesis. This proposal harnesses unique genetic models developed in the Papapetrou lab to characterize the cell-intrinsic and extrinsic effects of CH mutations and investigate the mechanisms that govern the initiation and progression of leukemogenesis.

PI_NAMEs: PAPAPETROU, EIRINI  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Advanced Malignant Neoplasm;Affect;Age;Alleles;Blood;Blood Tests;Bone Marrow;Cancer Model;Cardiovascular Diseases;cell immortalization;Cell Line;Cell Survival;cell transformation;Cells;Chromatin;Clinic;Clonal Evolution;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Counseling;cytokine;cytotoxic;Dependence;Disadvantaged;DNA Methylation;DNMT3a mutation;Dysmyelopoietic Syndromes;Engineering;Event;fitness;Gene Mutation;Genetic Models;Genetic Recombination;genetic testing;Genome;Genus Mentha;Goals;Guidelines;Hematopoiesis;Hematopoietic;hematopoietic stem cell expansion;Human;human induced pluripotent stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inflammatory;insight;Large-Scale Sequencing;leukemia;leukemogenesis;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;Molecular;Monitor;Morbidity - disease rate;Mus;mutant;Mutation;Myeloproliferative disease;Non-Hematologic Malignancy;Non-Malignant;Oncogenic;Organism;Pathology;patient derived xenograft model;Physiological;Precancerous Conditions;premalignant;Prevalence;Process;Risk;Risk Estimate;Role;SRSF2 gene;stressor;Techniques;Testing;Therapeutic;therapy outcome;Time;Tissues;transcriptome;tumorigenesis;Work;Xenograft procedure

PROJECT_TITLE: Mechanisms and therapeutic implications of human clonal hematopoiesis (CH) mutations


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Calcification that develops in leg arteries of patients with diabetes, chronic kidney disease, and peripheral artery disease is strongly associated with increased cardiovascular morbidity and mortality. This proposal seeks to demonstrate that a specific enzyme, the phosphodiesterase 10A (PDE10A), plays a crucial role in vascular calcification by regulating p38-MAPK-MMP-3 signaling. Our goal is to target PDE10A as a novel therapeutic strategy to reduce medial artery calcification and prevent amputation in our patients.

PI_NAMEs: CAI, YUJUN  (contact);GUZMAN, RAUL J.

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: Address;Amputation;Arterial Medias;Arteries;Attenuated;Bioinformatics;Blood Vessels;calcification;Cardiovascular system;Cell Physiology;Cells;Chronic Kidney Failure;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;Data;Deposition;Diabetes Mellitus;Drug Targeting;Durapatite;Enzymes;Event;experimental study;Extracellular Matrix;Family;Family member;Genes;Goals;Human;human disease;improved outcome;In Vitro;in vivo;inhibitor;inorganic phosphate;insight;Ischemia;Isoenzymes;knock-down;Knockout Mice;Leg;loss of function;Lower Extremity;MAP Kinase Gene;Matrix Metalloproteinases;Medial;Mediating;Metalloproteases;Modeling;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;novel;novel therapeutic intervention;osteogenic;overexpression;p38 Mitogen Activated Protein Kinase;Pathologic;Patients;Peripheral arterial disease;Pharmaceutical Preparations;phosphoric diester hydrolase;Physiological;Play;prevent;Process;Protein Isoforms;Rattus;Regulation;Risk;Rodent;Rodent Model;Role;Second Messenger Systems;Series;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Stromelysin 1;targeted treatment;Therapeutic;therapy development;Tibial Arteries;Time;Up-Regulation;Vascular calcification;Vascular Smooth Muscle

PROJECT_TITLE: Cyclic nucleotide phosphodiesterase regulation in vascular calcification


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Services;Pediatric;Prevention;Primary Health Care

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Despite many advances, many children with type 1 diabetes (T1D) and their families continue to struggle with diabetes management, placing them at risk for short- and long-term complications. Strong partnerships between T1D medical centers, families, and school health staff through a collaborative care model may better support these children to manage their chronic condition. In this proposal, we will adapt and test a school- partnered collaborative care model for T1D, with special attention to factors affecting implementation, acceptability, and sustainability.

PI_NAMEs: MARCH, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: Address;Administrator;Affect;aged;Area;arm;Attention;Behavior;behavioral health;care delivery;career development;Caregivers;Caring;Case Study;Child;Child health care;Child Support;Childhood;Chronic;Clinical Trials;Clinical Trials Design;Collaborations;collaborative care;Communities;community engaged approach;community engaged intervention;community organizations;community partners;community setting;Competence;contextual factors;Control Groups;cost;Data;Data Collection;data integration;design;diabetes management;Diabetes Mellitus;diabetes self-management;Effectiveness;effectiveness/implementation study;effectiveness/implementation trial;Ensure;Environment;Evaluation;Evidence based practice;Evidence based treatment;experience;Family;Family health status;feasibility testing;Feedback;Focus Groups;Fostering;Foundations;Funding Mechanisms;Future;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care delivery;Health Services Accessibility;Hospitals;Hour;implementation determinants;implementation measures;implementation research;implementation science;improved;Individual;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;Intervention;Interview;Lead;Leadership;Letters;Measures;Medical;Medical center;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Mission;Modeling;Modernization;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nursing Faculty;nutrition;Outcome;Outcome Measure;Parents;Patient Outcomes Assessments;Patient-Focused Outcomes;Physicians;pilot test;Policies;Preparation;Primary Care;primary outcome;Primary Schools;Process;programs;prototype;Provider;provider communication;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Design;Risk;Role;Sampling;school district;school health;School Nursing;Schools;Scientist;secondary outcome;skills;Social Workers;Specialist;success;Surveys;System;Testing;therapy design;Time;Training;Training Activity;treatment arm;usability;user centered design;Visit;Work;Youth

PROJECT_TITLE: School-Partnered Collaborative Care (SPACE) for Pediatric Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

PHR: PROJECT NARRATIVE Results from this study could help address the current mental health crisis among adolescent girls by leverag- ing real-time data to identify near-term risk factors that more optimally predict when girls will experience esca- lations in suicidality, as well as common earlier precursors to suicide such as nonsuicidal self-injury and de- pressive symptoms, and leveraging neuroimaging data to identify which girls may be at highest risk. This infor- mation is critical for improving real-time risk detection, designing just-in-time suicide prevention and inter- vention approaches, and accelerating the discovery of potential neural markers of risk and/or protection from these serious emotional health problems. Additionally, the study will provide rigorous empirical data on the real-time positive and negative links between social media use and adolescent emotional health that can inform public perceptions and policies surrounding social media use among adolescents.

PI_NAMEs: LADOUCEUR, CECILE D.;SILK, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Acceleration;Address;Adolescent;Affect;Affective;Age;Amygdaloid structure;Anterior;Behavior;Brain;Buffers;cingulate cortex;Clinical assessments;Collection;contextual factors;Data;data modeling;depressive symptoms;design;Detection;Diagnostic;digital;Dorsal;Ecological momentary assessment;Emotional;Evaluation;Exclusion;experience;Exposure to;Feeling suicidal;Female Adolescents;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Future;girls;Goals;Health;high risk;ideation;improved;Insula of Reil;Link;Machine Learning;Measures;media use;Mental Depression;Mental Health;Modeling;multilevel analysis;neural;neuroimaging;non-suicidal self injury;Nucleus Accumbens;Outcome;Outcome Assessment;Participant;peer;Perception;Personal Satisfaction;Persons;Play;Policies;Population;Predisposition;Prevention approach;Puberty;Published Comment;Reporting;Research;response;Rewards;Risk;Risk Factors;Risk Marker;Sampling;Self-Injurious Behavior;social;Social Environment;Social Interaction;social media;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Techniques;Technology;Testing;Text;Text Messaging;theories;Thinking;Time;tv watching;video chat;virtual assessment;Youth

PROJECT_TITLE: Neural sensitivity to social evaluation and daily online and in-person social experience with peers: Predicting fluctuations in suicidality, self-harm, and depressive symptoms in adolescent girls

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Chronic heart failure with reduced ejection fraction (CHF) affects millions of people and weakness of the diaphragm muscle that is used to breathe. Diaphragm weakness is a significant problem in patients because it contributes to morbidity and mortality. Our goal is to discover the cause and novel targets for prevention and treatment of diaphragm weakness in CHF.

PI_NAMEs: FERREIRA, LEONARDO  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Actins;activating transcription factor 3;adenovirus mediated delivery;Affect;alpha Actin;Amino Acids;Arrhythmia;ATP phosphohydrolase;Biological;Biological Process;Biology;Breathing;Characteristics;clinically relevant;Congestive Heart Failure;Coupled;Data;Dependovirus;Disease;Down-Regulation;Electron Microscopy;Enzymes;Equilibrium;Event;Excision;Exercise;experimental study;Fatigue;Female;Fiber;Filament;Functional disorder;Funding;Gel;Gene Expression Profile;Genes;Goals;Health;Heart failure;heart failure with reduced ejection fraction;Homeostasis;Human;Hydrophobicity;Impairment;injured airway;Intervention;Intramuscular Injections;Isometric Exercise;Isotonic Exercise;knock-down;Knowledge;Leucine;Limb structure;Literature;male;Mediating;Metabolism;Methionine;methionine sulfoxide reductase;Methods;Microfilaments;Modeling;Modification;Molecular;Morbidity - disease rate;Morphology;mortality;Muscle;Muscle Fatigue;Muscle function;Muscle Weakness;muscular structure;Mutation;Myosin ATPase;Nemaline Myopathies;novel;novel strategies;overexpression;oxidation;Oxidation-Reduction;Patients;Peripheral;Permeability;Persons;Phenotype;Plasmids;Pneumonia;polymerization;Polymers;Predisposition;prevent;Prevention;Process;Production;Property;protective effect;protein degradation;protein function;protein structure;Proteins;Proteomics;Publishing;Rattus;Reactive Oxygen Species;Regulation;Resistance;Respiratory Diaphragm;Respiratory Muscles;Role;Side;skeletal;Structure;Sulfhydryl Compounds;Testing;transcription factor;transcriptome sequencing;Tropomyosin;Troponin;vasoconstriction;ventilation;Viral

PROJECT_TITLE: Reactive Oxygen Species and Respiratory Muscle Dysfunction in Heart Failure

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Severe maternal morbidities are life-threatening conditions that can occur during delivery or postpartum, thereby causing short and long-term consequences for a woman and her family. Cardiovascular complications are the leading cause of postpartum maternal morbidity and are more common among Black and Hispanic women compared to White women. The proposed project will evaluate an innovative postpartum blood pressure monitoring program aimed at improving blood pressure management, decreasing health emergencies, and reducing population rates of cardiovascular related severe maternal morbidity among women of color.

PI_NAMEs: KELLEHER, SAMANTHA PARKER (contact);YARRINGTON, CHRISTINA DECK

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Accounting;Affect;Automobile Driving;barrier to care;Black race;black women;Blood Pressure;blood pressure control;Blood Pressure Monitors;Boston;Bypass;cardiovascular health;Cardiovascular system;Caring;Cellular Phone;Characteristics;cohort;Complex;Computing Methodologies;Data;data resource;Detection;digital divide;Discipline of obstetrics;Disparity;disparity reduction;Emergency Care;Emergency Situation;Emergent care;ethnic disparity;Event;experience;Family;Feedback;Goals;Health;health care availability;health care service utilization;Health Care Visit;health disparity;Heart failure;high risk;High Risk Woman;Hispanic;Hispanic Women;Home;Home Blood Pressure Monitoring;hospital readmission;Hospitals;Household;Hypertension;hypertension control;hypertensive;improved;Incidence;Individual;innovation;interest;Internet;Intervention;Interview;Latina;Life;Low income;maternal morbidity;Maternal Mortality;Measurement;Measures;Medical center;Modeling;Monitor;National Heart, Lung, and Blood Institute;New England;Not Hispanic or Latino;patient population;Patients;Pharmaceutical Preparations;Population;Postpartum Hypertension;Postpartum Period;Postpartum Programs;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;prepregnancy;programs;Provider;racial disparity;Records;Regimen;Research;Risk;Risk Factors;safety net;satisfaction;Schedule;Science;Self Management;Services;severe maternal morbidity;Special Population;Stroke;structural determinants;Structure;System;Translating;Triage;United States;United States National Institutes of Health;urgent care;Visit;web portal;White Women;wireless;Woman;women of color;women's morbidity

PROJECT_TITLE: Postpartum Remote Blood Pressure Monitoring Program: Study of Reducing Severe Maternal Morbidity among Black and Latina Women by Incorporating Patient Experiences and Systems Science

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Nutrition;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The collagen-rich desmoplastic stroma of pancreatic cancer has a big impact on its progression, aggressiveness, metastatic spread, and response to therapy, but the underlying mechanisms remain unknown. We found that cleaved collagen fragments stimulate pancreatic cancer growth and metabolism, whereas intact collagen fibers inhibit tumor growth. In this proposal, we will study the molecular mechanisms by which collagen fragments and fibers antagonistically control pancreatic cancer metabolism and growth through the receptor DDR1 and transcription factor NRF2.

PI_NAMEs: KARIN, MICHAEL  (contact);LEE, JUN HEE

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Ablation;AKT inhibition;Aldolase B;Antioxidants;Autocrine Communication;Binding;Biochemical;Biological;Cancer Etiology;Carbohydrates;Cells;Child;Chronic;chronic liver injury;Collagen;Collagen Fiber;DDR1 gene;Defect;defense response;Dependence;Desmoplastic;Development;Down-Regulation;EGF gene;Energy Metabolism;Enzymes;Erythroid;Exhibits;Fasting;Fatty Liver;Fiber;Fructose;gene induction;Generations;Genes;Genetic Transcription;Gluconeogenesis;Glucose;glucose metabolism;glycogen metabolism;Glycogen Storage Disease;Growth;Hepatic;Hepatocyte;Hepatomegaly;Homeostasis;Human;Hypertriglyceridemia;Hypoglycemia;hypoxia inducible factor 1;Individual;Inflammation;inhibitor;innovation;Insulin;Isoenzymes;Knockout Mice;lipid biosynthesis;lipid metabolism;Liver;Liver diseases;liver injury;liver metabolism;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;MAPK1 gene;MAPK3 gene;Mediating;Messenger RNA;Metabolic;metabolic phenotype;Metabolic stress;Metabolism;Molecular;mouse model;Mus;nonalcoholic steatohepatitis;novel;Nuclear;Nuclear Translocation;Oncogenes;Oncogenic;Oncoproteins;Overdose;overexpression;Pathology;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Physiology;Platelet-Derived Growth Factor;Post-Translational Protein Processing;Predisposition;Primary carcinoma of the liver cells;Protein Isoforms;Proteins;Proteolysis;Proteomics;Proto-Oncogene Proteins c-akt;receptor;recruit;Resistance;response;Role;Serine;Signal Transduction;Sorting;Stress;Technology;Testing;transcription factor;transcriptomics;treatment response;tumor growth;tumor metabolism;Tumor Suppressor Proteins;tumorigenesis;Ubiquitin;Ubiquitination;Up-Regulation

PROJECT_TITLE: The NRF2-FBP1 crossregulatory loop and the control of healthy and diseased liver metabolism

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE We seek to understand the neural basis of somatosensation – touch and proprioception – during manual interactions with objects. To this end, we measure time-varying limb postures, forces exerted on sensorized objects, and neuronal responses across the entire somatosensory neuraxis, as monkeys grasp objects whose size, shape, and location is under experimenter control. We then leverage what we have learned about somatosensory coding under active conditions to develop ever more intuitive ways to convey sensory feedback to bionic hands via electrical interfaces with somatosensory cortex.

PI_NAMEs: HATSOPOULOS, NICHOLAS G (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Sensory mechanisms of manual dexterity and their application to neuroprosthetics


NIH_SPENDING_CATS: Biotechnology

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE A network of signaling proteins convey and interpret information provided by T cell receptors to prevent human disease. The emergence of T cell-based therapies provides impetus to define the regulatory mechanisms used by the T cell signaling machinery to process information. The proposed research will use new approaches to interrogate the relationship between the regulation of signaling proteins and how a T cell perceives a potential antigenic agonist.

PI_NAMEs: COURTNEY, ADAM  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;antigen-specific T cells;Cells;Chemicals;Complex;Coupled;Data Set;desensitization;Discrimination;Disease;Ensure;extracellular;Feedback;Genetic Transcription;Genomics;Goals;Human;human disease;Immunologics;Label;Ligand Binding;Ligands;Mass Spectrum Analysis;medical schools;Michigan;novel strategies;Outcome;Phosphotransferases;prevent;Process;Property;protein complex;Proteomics;receptor;Receptor Signaling;Regulation;Research;Resources;response;Scanning;Signal Transduction;Signaling Protein;Surface;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapeutic;tool;transcriptome sequencing;Universities

PROJECT_TITLE: Mechanisms of ligand discrimination by the T cell signaling machinery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Data Science;Dementia;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: The abnormal atrial substrate (atrial cardiomyopathy) is associated with elevated risks of ischemic stroke dementia, and other cardiovascular outcomes, such as heart failure. Progress in preventing these adverse outcomes has been hampered by unresolved heterogeneity underlying atrial cardiomyopathy; hence, this K24 grant will support a project that will use machine learning and dense phenotypic data to identify clinically relevant subtypes of atrial cardiomyopathy. Additionally, this K24 grant will foster a supportive environment for the mentoring of junior investigators involved in patient-oriented research and facilitate acquisition of new cutting-edge skills by the PI and his mentees.

PI_NAMEs: CHEN, LIN YEE (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Acceleration;Address;adjudication;adverse outcome;aging population;Ancillary Study;Anticoagulants;Anticoagulation;aptamer;Area;arterial stiffness;Atherosclerosis Risk in Communities;Atrial Fibrillation;Automobile Driving;Biochemical;Biological;Biometry;Cardiology;Cardiomyopathies;cardiovascular health;Cardiovascular system;career;career development;Cessation of life;Classification;Classification Scheme;Clinical;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Cluster Analysis;cohort;Cohort Studies;Communities;Data;Data Analytics;data integration;Data Science;Dementia;design;Development;Doctor of Philosophy;Education;Electrocardiogram;Ensure;Epidemiologic Methods;Epidemiology;exome;Fostering;Functional disorder;Funding;Future;genome wide association study;Genomics;Grant;Heart Atrium;Heart failure;heart rate variability;heart rhythm;Heterogeneity;high risk population;improved;insight;Ischemic Stroke;Knowledge;Learning;Left;Left Atrial Function;Machine Learning;Measures;Medicine;Mentors;Methods;Minnesota;Molecular Epidemiology;Monitor;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;Myocardial Infarction;National Heart, Lung, and Blood Institute;next generation;Oral;Outcome;Pathogenesis;patient oriented research;Patient-Focused Outcomes;Patients;Pattern;Phenotype;phenotypic data;physician-scientist training program;Precision Medicine Initiative;Prevalence;prevent;Prevention;primary outcome;Procedures;programs;Proteomics;Public Health;Public Health Schools;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Risk Factors;Role;Science;skills;statistical learning;Stroke prevention;stroke risk;Structure;supportive environment;Techniques;Testing;Time;TNFSF15 gene;tool;Training;Training Programs;Two-Dimensional Echocardiography;United States National Institutes of Health;Universities;unsupervised learning;Visit;Work

PROJECT_TITLE: Mentoring and Research to ClassifyAtrial Cardiomyopathy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Bioengineering;Breast Cancer;Cancer;Clinical Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project narrative We propose a path to commercialize an affordable, automated breast cancer detection (GeneXpert® BCD) assay that analyzes our published, hypermethylated gene panel in fine needle aspirates of palpable breast lesions to rapidly detect malignancy, for use in low- and middle-income countries. In collaboration with our industrial partner, Cepheid, and our clinical team in South Africa, we will analytically and clinically validate the assay for future commercialization. Innovative approaches to increase early detection and decrease treatment delays of breast cancer can save thousands of lives in the many resource-poor areas of the world.

PI_NAMEs: SUKUMAR, SARASWATI  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: 2019-nCoV;advanced disease;Affect;Africa;Africa South of the Sahara;Age;Asia;Benign;Biological Assay;biomarker panel;Biopsy;bisulfite;Body mass index;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Early Detection;breast lesion;Cancer Detection;Cessation of life;Characteristics;Clinic;Clinical;clinical practice;Clinical Research;Collaborations;commercialization;Communicable Diseases;Communities;Core Biopsy;cost;Death Rate;detection assay;Developing Countries;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;Disparity;DNA;DNA Methylation;DNA Modification Process;Early Diagnosis;Engineering;Ensure;Equilibrium;Female Breast Carcinoma;Fine needle aspiration biopsy;Future;gene panel;Generations;Genes;Goals;high risk;HIV-1;Hour;Hypermethylation;imaging facilities;improved;Industrialization;industry partner;innovation;Intervention;Laboratories;Legal patent;Lesion;low and middle-income countries;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Manuals;Mass in breast;Measures;Mediating;Methods;Methylation;methylation biomarker;Modification;Molecular;Molecular Diagnosis;mortality;operation;Palpable;Pathologist;Pathology;Patient Selection;patient subsets;Patients;Performance;Persons;Population;Predictive Value;Prospective Studies;prototype;Publishing;Race;rapid detection;rapid test;Reproducibility;Resource-limited setting;sample collection;Sampling;screening;Sensitivity and Specificity;Slide;South Africa;Specificity;Techniques;Technology;Testing;Time;Tissues;Training;tumor;tumor DNA;Tumor Subtype;underserved area;Underserved Population;United States;Validation;Woman;Women's study

PROJECT_TITLE: DEVELOPMENT OF AN AUTOMATED CARTRIDGE-BASED BREAST CANCER DETECTION ASSAY- AN ACADEMIC-INDUSTRIAL PARTNERSHIP


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Understanding the complex web of brain regions that control feeding behavior is critical for understanding and treating obesity. Although typically considered in relation to motor control, converging lines of evidence suggest that the cerebellum--an ancient brain region containing >1/2 of all neurons in the human brain and possessing powerful mechanisms for learning--also plays an important role in cognition and motivated behavior. The goal of this proposal is to identify a potentially vital role for the cerebellum in the adaptive regulation of feeding behaviors related to obesity.

PI_NAMEs: LEIBEL, RUDOLPH L;SAWTELL, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Anterior;Attention;Behavior;Behavioral;Body Weight;Brain;brain behavior;Brain region;cell type;Cells;Cerebellar Cortex;Cerebellum;Cerebral cortex;Cognition;Cognitive;Complex;Consumption;Data;Desire for food;Disease;Eating;Electrophysiology (science);Environment;experience;experimental study;Fatty acid glycerol esters;feeding;Feeding behaviors;Foundations;genetic manipulation;Goals;granule cell;hedonic;Human;Internet;Learning;Link;Maps;Mediating;Metabolic;Methods;microstimulation;Modeling;Monitor;motivated behavior;Motor;motor control;Movement;Mus;neural circuit;Neural Pathways;Neuroanatomy;Neurons;novel;Obesity;obesity treatment;optogenetics;pharmacologic;Physiological;Physiology;Play;Prevention;Regulation;Resolution;Role;Silicon;Site;Spinal Cord;Synaptic plasticity;Viral

PROJECT_TITLE: Neuroanatomic and Functional Characterization of Cerebellar Circuits Mediating Ingestive Behaviors

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: LM

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: MADISON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The University of Wisconsin’s Computation and Informatics in Biology and Medicine (CIBM) program is training the next generation of scientists with deep and broad expertise in biomedical informatics and data science. The predoctoral trainees in the program will develop and apply state-of-the art methods to advance our understanding of human biology and promote human health, in focus areas such as Alzheimer’s disease, breast cancer, hyperparathyroidism, pathogenic viruses, pharmacogenomics, and regenerative medicine.

PI_NAMEs: CRAVEN, MARK W. (contact);DEWEY, COLIN NOEL

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Address;Algorithms;Biology;biomedical informatics;career;Clinical Research;Collaborations;computer science;Country;Data Science;Development;Discipline;Ecosystem;Ensure;Ethics;experience;Faculty;Foundations;Funding;graduate student;Grant;Health;HIV Infections;Human;improved;Informatics;insight;Interdisciplinary Study;Medicine;meetings;Mentorship;Methods;Minority Recruitment;National Institute of Allergy and Infectious Disease;next generation;patient population;Positioning Attribute;pre-doctoral;programs;recruit;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;responsible research conduct;Scientist;Series;Solid;statistics;success;Training;Training Programs;Underrepresented Minority;Universities;Wisconsin


NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Infectious Diseases;Prevention;Topical Microbicides;Women's Health Research

ORG_CITY: MONROVIA

ORG_NAME: OAK CREST INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE Current HIV prevention strategies that require daily oral dosing are burdensome to the user and, consequently, are often not followed. We will use state-of-the-art chemistry and pharmacology research to build on our successes and continue the development of a long-acting, one-year implant for sexual HIV prophylaxis. The proposed research is relevant to public health because it will lead to a rigorous, mechanistic understanding of the innovative devices' mode of action, protect all the relevant anatomic sites, and significantly improve clinical practice for HIV prevention and, possibly, treatment.

PI_NAMEs: BAUM, MARC MICHAEL (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Academia;Address;Adherence;Adverse reactions;AIDS prevention;Anatomy;Animals;Anti-Retroviral Agents;Automobile Driving;Canis familiaris;Characteristics;Chemistry;Clinical;clinical practice;Clinical Trials;Complement;Contracts;controlled release;Data;Dermal;design;Development;Devices;Diffusion;Dimensions;Diphosphates;Dose;drug candidate;Drug Controls;Drug Delivery Systems;Drug Exposure;Drug Kinetics;Drug or chemical Tissue Distribution;Effectiveness;efficacy study;Epidemic;Evaluation;Excipients;experience;Feedback;Female;flexibility;Foreign Bodies;Formulation;Frequencies;Future;global health;Goals;health organization;HIV;HIV Infections;HIV-1;Hour;Human;Image;imaging modality;Immune response;Implant;implant design;implant material;implantation;improved;In Vitro;in vivo;Individual;Industry;Infection;infection rate;Injectable;Injections;innovation;Investigation;Knowledge;Lead;lead candidate;Macaca;Macaca mulatta;male;manufacturability;mass spectrometric imaging;meetings;Membrane;metabolomics;Methods;Modeling;Monitor;multidisciplinary;Mus;next generation;non-invasive imaging;nonhuman primate;Nucleosides;Oral;particle;penis;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Population Heterogeneity;Porosity;pre-clinical;pre-exposure prophylaxis;pre-Investigational New Drug meeting;preclinical development;preclinical study;Predisposition;Preparation;prevent;Prevention;Prevention strategy;Process;Prodrugs;Property;prophylactic;Prophylactic treatment;Proteomics;prototype;Public Health;Published Comment;Rattus;Rectum;Regimen;Research;research clinical testing;response;Reverse Transcriptase Inhibitors;Risk;Safety;safety assessment;safety study;Science;Sheep;simian human immunodeficiency virus;simulation;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;subcutaneous;success;Tenofovir;Testing;Ultrasonography;United States National Institutes of Health;Vagina;Writing

PROJECT_TITLE: Systemic Sustained Release Delivery of Antiretroviral Agents for HIV Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-M(02)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: RICHMOND

ORG_NAME: VA VETERANS ADMINISTRATION HOSPITAL

ORG_STATE: VA

PHR: Many Veterans suffer chronic pain from deployment-related injuries or other causes, resulting in poor quality of life. The amount of disability a Veteran suffers is a combination of injury (biological or neurological processes) and mental interpretation of the pain signals. In many cases, no physical problem is detected in an X-ray or other scan. Patients whose pain disability is amplified by psychological factors can benefit from receiving cognitive behavioral therapy and other mental health (MH) care in addition to medical procedures. However, many refuse this MH care. To help motivate these Veterans, this study will explore whether subconscious bias toward pain revealed in special computer tasks may be a useful marker to identify Veterans who could benefit from MH care. The study will explore how feasible it is to test for this bias with computer tasks, and whether subconscious bias is greater in pain patients compared to other kinds of Veteran patients, and whether bias relates to other measures of psychological distress. These data will help develop a mobile app that could motivate MH care.

PI_NAMEs: BJORK, JAMES M (contact)

PROJECT_TERMS: Adopted;Affect;Affective;Afghanistan;Aggressive behavior;Algorithms;Anxiety;Appointment;arm;assessment application;Attention;attentional bias;Attitude;Award;Back;Belief;Biological Markers;Biological Process;biopsychosocial;Brain Concussion;Caring;Central Nervous System;central sensitization;Chronic;chronic pain;Clinic;Clinical Trials;Cognitive Therapy;comorbidity;computerized;Computerized Medical Record;Computers;cost;Data;disability;Disability treatment;Disease;Distress;Economics;Employment;Endocrine;environmental stressor;follow-up;Frustration;functional improvement;functional outcomes;Goals;Headache;Health Personnel;Home;Image;Immune response;implicit bias;impression;improved;Impulsivity;Individual;Individual Differences;Injury;instrument;Intake;interdisciplinary approach;Interview;Iraq;Laboratories;laptop;Lifting;Light;Low Back Pain;Measurement;Measures;Medical;Medical center;Mental Depression;Mental disorders;mental function;Mental Health;Mental Health Services;Military Personnel;mobile application;Modeling;Moods;motivational enhancement therapy;musculoskeletal injury;neurobehavioral;Neurocognitive;Neurologic Process;neuropathology;Non-Malignant;Observational Study;Occupational;opioid use;Outcome;Pain;Pain Clinics;Pain management;pain patient;pain perception;pain rehabilitation;pain signal;pain symptom;Participant;Patient Self-Report;Patients;Performance;Peripheral Nervous System;Persons;Physical therapy;portability;Post-Traumatic Stress Disorders;Primary Care;Probability;Procedures;Provider;Psyche structure;psychologic;psychological distress;Psychological Factors;Quality of life;Quality of Life Assessment;Reaction Time;Recommendation;Recording of previous events;recruit;Rehabilitation Outcome;rehabilitation research;Rehabilitation therapy;Reporting;Research Design;Risk;Risk Factors;Roentgen Rays;routine practice;Scanning;Semantics;Services;smartphone based assessment;stem;Stimulus;Subconscious;Substance abuse problem;suicidal;Suicide;Suicide attempt;symptomatology;Symptoms;Tablets;Telephone Interviews;Temperament;Testing;Time;tool;touchscreen;Training;Traumatic Brain Injury;Treatment outcome;treatment planning;United States;Veterans

PROJECT_TITLE: Mental Function And Quality Of Life With Chronic Pain

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]