NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Pediatric

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Chronic exposure to diabetogenic environments such as inflammation can alter β-cell to β-cell communication which can impact the overall function and survival of these cells during Type 1 diabetes (T1D) pathogenesis. Emerging evidence has implicated circulating membrane-derived nanovesicles termed extracellular vesicles (EVs) as mediators of T1D pathogenesis through the delivery of harmful β-cell EV cargoes to recipient β-cells to induce dysfunction. The overall goal of this project is to understand how alterations in β-cell EV cargo can change the physiological state of the β-cell and the mechanisms behind this process, which will help to afford novel biomarker and therapeutic strategies to improve β-cell health in T1D.

PI_NAMEs: JAVEED, NAUREEN  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: adaptive immunity;Address;Animal Model;Antigen Presentation;Antigen Presentation Pathway;Apoptosis;Apoptotic;Autocrine Communication;autoimmune pathogenesis;Autoimmunity;Beta Cell;Binding;blood glucose regulation;Cell Communication;Cell Line;Cell Physiology;Cell Proliferation;Cell surface;Cell Survival;cell type;Cells;chemokine;Chronic;Clinic;Complex;CXC chemokine receptor 3;CXCL10 gene;CXCR3 gene;cytokine;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Diabetes Mellitus;diabetes pathogenesis;diabetogenic;Disease;Disease Outcome;DNA;effector T cell;Endoplasmic Reticulum;endoplasmic reticulum stress;Environment;exosome;Exposure to;extracellular vesicles;Failure;Functional disorder;Funding;gene network;Genes;Genetic;Genetic Transcription;Glucose;Goals;Health;Homeostasis;Human;Hyperglycemia;immune cell infiltrate;immune modulating agents;Immune Tolerance;immunogenic;immunoregulation;Impairment;improved;in vivo;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;intercellular communication;Intervention;islet;Knowledge;Laboratories;life span;Link;Lipids;loss of function;Lymphocyte;Macrophage;Major Histocompatibility Complex;Mediating;Mediator;Membrane;Mentors;MicroRNAs;microvesicles;migration;mouse model;nanovesicle;Natural Immunity;Natural regeneration;Nature;new therapeutic target;novel;novel marker;novel strategies;novel therapeutic intervention;Onset of illness;Paracrine Communication;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Physiological;Play;Population;Predisposition;preservation;Preventive treatment;Process;Proteins;Receptor Inhibition;recruit;Regenerative Medicine;Reporting;Research;Research Personnel;response;RNA;Role;Signal Transduction;STAT1 gene;Stress;stressor;Structure of beta Cell of islet;success;Susceptibility Gene;T-Lymphocyte;Testing;Therapeutic Intervention;therapeutic target;tool;Transcript;transcription factor;treatment strategy;United States National Institutes of Health;Vesicle;Work

PROJECT_TITLE: Role of Small Extracellular Vesicles in Beta Cell Failure and Autoimmunity in Type 1 Diabetes Mellitus

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE The proposed research will apply novel and established techniques and approaches towards understanding the molecular mechanism of function of a physiologically important class of ion channels, the cyclic nucleotide gated channels, that are responsible for visual and olfactory signal transduction and the pacemaking activity of the heart and brain. Understanding the fundamental mechanisms of channel workings is a prerequisite to understanding the critical physiological processes they control. The insight we gain into the basic mechanism of this important class of channels will enable the design and discovery of novel therapeutics that specifically target the channels responsible for particular disease conditions.

PI_NAMEs: NIMIGEAN, CRINA M (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Agonist;antagonist;Arrhythmia;Atomic Force Microscopy;Behavior;Binding;Biological Assay;Brain;Cell Physiology;Cells;cis trans isomerization;Color blindness;combinatorial;Cryoelectron Microscopy;Cyclic AMP;Cyclic GMP;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;Defect;design;Disease;Electrophysiology (science);Enzymes;Epilepsy;Equilibrium;experimental study;Goals;Grant;HCN1 gene;Heart;Heterogeneity;Image;improved;insight;Investigation;Isomerism;Kinetics;Lead;Length;Ligands;Lipid Bilayers;Lipids;Liposomes;Mass Spectrum Analysis;Measures;Modality;Modeling;Molecular;Molecular Conformation;Monitor;mutant;Mutate;Mutation;Nervous System;novel;novel therapeutics;Output;particle;patch clamp;Peptidylprolyl Isomerase;Phase;Physiological;Physiological Processes;Play;Population;Probability;Process;Proline;Property;Proteins;reconstitution;Regulation;Reporting;Research;Resolution;response;Role;S phase;Sampling;sensor;Signal Transduction;single molecule;Spectrum Analysis;stopped-flow fluorescence;Structure;Surface;Techniques;Testing;Time;Visual;Visual Signal Transduction Pathway;voltage

PROJECT_TITLE: Structural dynamics in cyclic nucleotide-modulated channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health

ORG_CITY: MORGANTOWN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: The overall goal of this project is to increase numbers of clinical trials and observational cohort studies in Institutional Development Award (IDeA) states that currently have less than 10% of active NIH supported trials. Strategies to accomplish this goal include communicating to trial sponsors the expertise, quality, and capacity of IDeA state institutions to conduct clinical trials and to IDeA investigators available clinical trial opportunities. We will also train a cadre of skilled research coordinators across IDeA states to provide the necessary workforce capacity to conduct increased numbers of trials.

PI_NAMEs: HODDER, SALLY LYNN (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Academy;Address;Adult;American;Area;Award;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Skills;clinical trial participant;Clinical Trials;clinically relevant;Cohort Studies;Collaborations;Communication;Conduct Clinical Trials;Data;Databases;Decision Making;Development;Eligibility Determination;eligible participant;Enrollment;Ensure;Expenditure;experience;Funding;Goals;Human Resources;Individual;Industry;Institution;institutional capacity;interest;Journals;Leadership;Long COVID;Marketing;Mentorship;Methods;Minority Groups;Minority Participation;Monitor;National Institute of General Medical Sciences;observational cohort study;Observational Study;online delivery;Participant;patient population;Patient Recruitments;Pharmacists;Phase;Principal Investigator;Program Development;Program Evaluation;programs;Puerto Rico;repository;Research;Research Personnel;Resources;rural America;rural Americans;Rural Population;Series;Services;Site;skills;Structure;success;Time;Training;Translational Research;Underrepresented Minority;Underserved Population;United States;United States National Institutes of Health;web site;West Virginia

PROJECT_TITLE: The IDeA State Consortium for a Clinical Research Resource Center: Increasing Clinical Trials in IDeA States through Communication of Opportunities, Effective Marketing, and WorkforceDevelopment


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Relevance: The brain shows marked plasticity across a variety of learning and memory tasks as well as during recovery after injury. This proposal aims to investigate targeted stimulation of cortex to drive cortical plasticity and induce functional recovery via state-of-the-art electrophysiology and optogenetics to simultaneously record and manipulate activity of sensorimotor neurons in awake behaving macaques. Understanding the role of these basic physiological phenomena will shed light on underlying mechanisms of brain plasticity that leads to functional reorganization in the brain and can provide us with vital insight to develop stimulation-based therapies for a broad range of neurological disorders such as stroke.

PI_NAMEs: YAZDAN SHAHMORAD, AZADEH  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Area;awake;behavior measurement;Behavioral;Brain;brain machine interface;cell type;density;design;Disease;Effectiveness;Electrophysiology (science);Engineering;experimental study;Foundations;Future;Goals;Human;injured;Injury;injury recovery;insight;Ion Channel;Ischemia;ischemic lesion;Learning;Lesion;Light;Location;Macaca;Maps;Measures;Memory;Morphologic artifacts;Motor Cortex;Nervous System Disorder;neural;neural patterning;neurological rehabilitation;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;novel;novel strategies;optogenetics;Pattern;Physiologic pulse;Physiological;Recovery of Function;Rehabilitation therapy;Reporting;Research;Role;sensorimotor system;Solid;Somatosensory Cortex;Specificity;Stroke;System;Techniques;Testing;Therapeutic Intervention;Time;tool;Transfection;Viral

PROJECT_TITLE: Engineering neuroplasticity using volitional control of activity-dependent optogenetic stimulation in macaque sensorimotor cortex

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The Greater Boston MSTAR Program at Harvard Medical School was developed to address the increasing need for medical students to pursue careers in aging research and geriatrics. By exposing students to this field early in their careers, this proposal addresses these needs by providing aging research training for 11 students per year for the next 5 years.

PI_NAMEs: DRIVER, JANE A (contact);MCLAUGHLIN-GAVIN, CARA

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academic Medical Centers;Aging;American;Boston;career;Clinical;Country;Direct Costs;Educational process of instructing;experience;Funding;Future;Geriatrics;Grant;Heart;human subject protection;interest;Jackson Heart Study;Massachusetts;matriculation;Medical;medical schools;Medical Students;meetings;Mentors;Minority Recruitment;Mississippi;Oral;Paper;programs;Publishing;Reporting;Research;Research Methodology;Research Project Grants;Research Training;Role;Societies;Student Selections;student training;Students;success;Training;Universities;Work

PROJECT_TITLE: Greater Boston Medical Student Training in Aging Research


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BERKELEY

ORG_NAME: SCIENCE COMMUNICATION LAB, INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many qualified students, especially students from historically underrepresented groups (i.e., women and racial minorities), are choosing not to pursue graduate education in the biomedical sciences, or are leaving biomedical science graduate training programs early, creating a critical deficit in  the unique perspectives necessary to perform the innovative research that will benefit the health of our increasingly diverse population . Good mentoring relationships are critical for recruiting and retaining students with diverse backgrounds in science because they provide encouragement, guidance, and social support that enhance student personal and professional development, as well as their integration into the scientific profession. To promote good mentoring relationships, we will build online courses that will empower students with the ability to establish and maintain positive mentoring and collegial relationships shown to be associated with successful biomedical research careers.

PI_NAMEs: BRANCHAW, JANET L;GOODWIN, SARAH S (contact);KOSHLAND, DOUGLAS E

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Awareness;Biomedical Research;career;Career Choice;career development;Career Mobility;career preparation;Collaborations;Communication;Communities;community building;Competence;Course Content;Data;Development;E-learning;Education;Educational Curriculum;Educational process of instructing;empowerment;Ensure;Environment;Equity;Evaluation;evaluation/testing;evidence base;Face;Feedback;Graduate Education;graduate school;graduate student;Health Benefit;innovation;Institution;Instruction;Learning;learning community;Mentors;Modeling;online community;online course;Outcome;outreach;Participant;pilot test;Population Heterogeneity;programs;Publications;Qualifying;racial minority;recruit;Reporting;Reproducibility;Research;Research Training;Resources;responsible research conduct;Science;Scientist;Site;skill acquisition;skills;Social support;student participation;student retention;student training;Students;Surveys;Testing;Time;Training;Training Programs;undergraduate student;Underrepresented Populations;Universities;Update;Wisconsin;Woman;Work

PROJECT_TITLE: Online Courses for Navigating Research Mentoring Relationships


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research program is relevant to public health because it advances imaging science and technology to transform biomedical research. The results will open up novel methodological pathways and illuminate both fundamental and translational discoveries. The proposed research is relevant to the part of NIGMS’s mission that it advances basic biomedical research by supporting the development of biomedical technologies to enable studies that underlie health and disease.

PI_NAMEs: JIA, SHU  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Address;Biological;Biological Sciences;biological systems;Biology;Biomedical Research;Biomedical Technology;Biophotonics;Cells;Development;Disease;Engineering;Foundations;Goals;Health;Heterogeneity;high dimensionality;Image;Image Enhancement;Imaging Device;imaging platform;imaging science;Imaging technology;in vivo imaging;Infrastructure;innovation;Instruction;Investigation;Laboratories;Leadership;Light;Medical;Methodology;Methods;Microscopy;Mission;Modality;nanoscale;National Institute of General Medical Sciences;novel;Organelles;Pathway interactions;Physics;Population;programs;Public Health;Research;Research Support;Resolution;restraint;Role;Science;superresolution microscopy;System;Technology;Therapeutic;Time;Tissues;Translations;ultra high resolution;Variant

PROJECT_TITLE: Toward Systems Biophotonics: Imaging Biology across High Dimensions and Scales

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The number of adolescents living with HIV (ALHIV) in Uganda is over 170,000 and growing, yet less than 50% of ALHIV in Uganda are ART-adherent, leading to low rates of viral suppression due to social and structural inequities. Informed by the multi-phase optimization strategy (MOST), we propose to conduct a factorial experiment (optimization trial) to identify the most cost-effective combination of four-intervention components for viral suppression and ART adherence, as well as mental health and several psychosocial outcomes among ALHIV in Uganda. The proposal will unpack a multi-component combination intervention named Suubi that uses economic empowerment and psychosocial intervention components to address social and structural inequities, with the goal of optimizing the Suubi intervention to enhance scale up in health systems and advance intervention science for HIV care globally.

PI_NAMEs: SAUCEDA, JOHN ANDREW;SSEWAMALA, FRED M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Achievement;Address;Adherence;Adolescent;aged;AIDS prevention;antiretroviral therapy;care outcomes;Caring;Cartoons;Clinic;cohesion;comparative cost effectiveness;cost;Cost Analysis;cost comparison;cost effective;Data;Economics;Effectiveness;empowerment;Engineering;Enrollment;Equilibrium;evidence base;experience;experimental study;Family;financial literacy;follow up assessment;Foundations;Funding;geographically distant;Goals;Health;Health Status;Health system;HIV;HIV Infections;HIV-infected adolescents;improved;Incentives;Income;Inequity;Infrastructure;innovation;Intervention;Intervention Studies;Kenya;Knowledge;Lived experience;Manuals;Mediation;Mediator;meetings;Mental Health;Methods;Modernization;multiphase optimization strategy;Names;Outcome;Performance;Positioning Attribute;prevent;primary outcome;psychosocial;psychosocial outcome;Randomized;Resources;response;Risk;role model;Savings;scale up;Science;social;social stigma;Specific qualifier value;success;Techniques;Testing;theories;therapy adherence;Training;Uganda;United States National Institutes of Health;Viral;Viral Load result;Work;Youth

PROJECT_TITLE: Suubi+Adherence4Youth: Optimizing the Suubi Intervention for Adherence to HIV Treatment for Youth Living with HIV in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-M(53)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE In this grant cycle, we test whether right and left hemisphere temporal regions have different roles in processing the sounds of speech, examining neuroimaging and TMS data from typical controls and behavioral data from individuals with left and right temporal lobe lesions. Understanding the roles of right and left hemisphere regions is key to developing appropriate rehabilitation strategies for people with aphasia.

PI_NAMEs: MYERS, EMILY B (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TITLE: The Role of Frontal and Temporal Brain Areas in the Perception of Phonetic Category Structure


NIH_SPENDING_CATS: Cancer

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Cellular membranes not only compartmentalize intracellular processes, but also serve as the dynamic hubs for the assembly of many multi-protein signaling complexes, oncoproteins, and tumor suppressors. This proposal will investigate the role played by membrane anchored substrate degradation via the ubiquitin proteasome system, modulating communication networks for cell survival and proliferation. The results of this application are expected to impact cancer and cardiac biology.

PI_NAMEs: KUCHAY, SHAFI M. (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Biological;Biology;C-terminal;Calibration;Cardiac;Cell Proliferation;Cell Survival;Cellular Membrane;Communication;Complement;Complex;Cues;Degradation Pathway;Dimethylallyltranstransferase;Disease;F-Box Proteins;FBXL2 gene;genetic regulatory protein;Heart Diseases;Human;interdisciplinary approach;Investigation;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;membrane model;Membrane Proteins;Molecular;multicatalytic endopeptidase complex;Nervous System Disorder;novel;Oncoproteins;Pharmaceutical Preparations;pharmacologic;Physiological;Play;prenylation;Process;protein degradation;Proteolysis;Proteome;proteostasis;Regulation;response;Role;Signaling Protein;SKP Cullin F-Box Protein Ligases;System;Therapeutic;Tumor Suppressor Proteins;Ubiquitin;ubiquitin ligase;Work

PROJECT_TITLE: Proteostasis at cellular membranes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Social Determinants of Health

PHR: NARRATIVE The goal of this training program is to strengthen research that will ultimately improve cardiovascular disease (CVD)-related health outcomes in Haiti and the world. We will address the knowledge gaps in understanding and intervening in the CVD epidemic in Haiti by providing mentored CVD research training to Haitian investigators, training research staff in technical CVD skills, and establishing a CVD Implementation Network to accelerate the uptake of CVD interventions across the country. This would be the first CVD-specific research training program in Haiti and is urgently needed to expand locally driven CVD research.

PI_NAMEs: MCNAIRY, MARGARET LEIGHTON (contact);PAPE, JEAN WILLIAM

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Adult;Black American;Cardiovascular Diseases;cardiovascular disorder risk;career development;Clinic;Clinical;Collaborations;Communicable Diseases;Country;Disease;Educational process of instructing;Educational workshop;Environmental Pollutants;Epidemic;Evaluation;Faculty;food insecurity;Foundations;Goals;Grant;Haiti;Haitian;Health;high salt diet;HIV;Hypertension;improved;Infection;innovation;International;Intervention;Knowledge;lead exposure;leadership development;Medicine;Mentors;Morbidity - disease rate;mortality;next generation;Outcome;Persons;Poverty;Prevalence;programs;Psychological Stress;Recording of previous events;Research;Research Personnel;Research Training;Risk Factors;Scientist;skills;social determinants;symposium;Training;Training Programs;United States National Institutes of Health;Universities;uptake

PROJECT_TITLE: Cardiovascular Disease Research Training Program in Haiti

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Drug formulations are key to enable the safe and effective delivery of therapeutics but are currently costly to produce or insufficiently optimized for specific drugs and specific patients. We will here develop novel platforms that tightly integrate machine learning and experiments to more rapidly and effectively design (1) functional excipients, (2) targeted nanoparticles, and (3) prodrugs. Our research will pioneer and prototype innovative approaches in the nascent field of computational drug delivery and will also produce targeted drug formulations that provide safer and more effective therapies for every patient.

PI_NAMEs: REKER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Complex;cost;Data;design;Development;Drug Delivery Systems;Drug Design;Drug Formulations;Drug Targeting;effective therapy;Ensure;Equity;Excipients;experimental study;Formulation;Goals;In Vitro;in vivo;innovation;Life;Machine Learning;machine learning method;machine learning model;manufacture;Medicine;Metabolism;microbiome;nanoparticle;novel;novel therapeutics;Patients;Pharmaceutical Preparations;Pharmacologic Substance;physical property;Positioning Attribute;pre-clinical;prevent;Prodrugs;prototype;Research;Safety;self assembly;System;Therapeutic;Tissues;Translations;Validation;Work

PROJECT_TITLE: Designing Personalized Formulations with Machine Learning


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Clinical Research;Disability Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE The aim of this project is to bring together engineers and a group of multi-disciplinary clinicians to develop the Comprehensive Augmented Reality Testing (CART) platform to enhance the understanding and treatment of Parkinson’s disease (PD). The CART platform will utilize augmented reality technology to systematically evaluate motor and cognitive function and the performance of instrumental activities of daily living on a single technology platform. Following completion of software development, a series of validation and reliability experiments will be competed in 140 individuals with PD, evenly dispersed among Hoehn & Yahr stages, and 35 age-matched controls to ensure the CART platform provides accurate and actionable information about PD symptoms to ultimately advance PD treatment strategies and discovery.

PI_NAMEs: ALBERTS, JAY L. (contact);KOOP, MANDY MILLER

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Activities of Daily Living;Advisory Committees;Age;Alzheimer's Disease;Area;Attention;Augmented Reality;Biological Markers;Biomechanics;Biomedical Engineering;Bradykinesia;Caring;Clinical;Clinical assessments;clinical care;clinical decision-making;clinical diagnosis;cognitive function;cognitive task;cohort;Cohort Studies;Collaborations;computer generated;Coupled;Data;Deep Brain Stimulation;Development;Devices;digital;digital imaging;Disease;Disease Progression;effective therapy;Electronics;Engineering;Ensure;Environment;Exhibits;experimental study;falls;Fingers;food preparation;Future;Gait;Gait abnormality;Goals;Human;Image;Independent Living;Individual;Individual Differences;innovation;instrumental activity of daily living;Letters;Life;Link;Measurement;Measures;Medical;Military Personnel;Modeling;Monitor;Motion;Motor;Movement;Movement Disorder Society Unified Parkinson's Disease Rating Scale;multidisciplinary;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurology;Neuropsychology;neurosurgery;novel;Outcome;Outcome Measure;Parkinson Disease;patient oriented;Patients;Pattern;Performance;Pharmaceutical Preparations;Physical therapy;population based;Psychometrics;Reality Testing;sensor;Series;software development;Software Engineering;Soldier;Standardization;statistics;success;symposium;symptom treatment;Symptoms;System;Task Performances;Technology;technology platform;Testing;Time;treatment strategy;Tremor;Validation;Validity and Reliability

PROJECT_TITLE: Comprehensive Augmented Reality Testing (CART) Platform for Parkinson’s disease

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Our PCDC-RU proposal aims to address the critical clinical unmet needs of pancreatic ductal adenocarcinoma (PDAC). We plan to develop in vitro diagnostic multivariate index assays (IVDMIA) that combine a panel of biomarkers into a single-valued numerical index for the early detection of PDAC and high-risk lesions. The discovery, verification, validation and translation of pancreatic cancer biomarkers into clinical diagnostics, as well as the development of clinical-grade assays will be accomplished through partnerships with other PCDC-RUs, the MDCU, and the diagnostics industry.

PI_NAMEs: BRAND, RANDALL ;CHAN, DANIEL WANYUI (contact);ZHANG, HUI ;ZHANG, ZHEN

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;algorithm development;assay development;Benign;biobank;Biological Assay;Biological Markers;biomarker development;biomarker panel;biomarker selection;cancer biomarkers;candidate marker;candidate selection;Clinic;Clinical;Clinical Chemistry;clinical development;clinical diagnostics;Complex;Cyst Fluid;Cystic Neoplasm;Data;Data Science;design;Development;Diagnostic;Diagnostic Procedure;direct patient care;Disease;Distant;Distant Metastasis;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Endoscopic Ultrasonography;Evaluation;General Population;Goals;high risk;high risk population;Image;in-vitro diagnostics;indexing;Individual;Industry;innovation;laser capture microdissection;Lesion;Localized Malignant Neoplasm;Low Prevalence;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;member;Methods;Molecular;Morbidity - disease rate;mortality;Mucinous;Mucinous Neoplasm;multidisciplinary;multimodality;Nature;novel strategies;Numerical value;Operative Surgical Procedures;Pancreas;pancreas development;Pancreatic Ductal Adenocarcinoma;Papillary;Pathology;Pathway interactions;Patients;Phase;Post-Translational Protein Processing;premalignant;Prevalence;Primary Neoplasm;Process;Prognosis;Proteins;proteogenomics;Proteomics;Recommendation;Recording of previous events;Regional Disease;Research;research clinical testing;Research Personnel;Resected;Resources;Risk;Sampling;Science;screening;Serum;Specimen;statistical and machine learning;success;surveillance imaging;Survival Rate;System;Technology;Testing;Tissue Banks;Tissue Sample;Tissues;Translations;tumor;Unresectable;Validation

PROJECT_TITLE: Development of a panel of multiplex biomarkers for the early detection of pancreatic ductal adenocarcinoma and high-risk lesions


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Irradiations with extreme dose rates (FLASH) has been shown to greatly spare healthy tissue while not affecting tumor control, promising to significantly improve radiation therapy (RT). However, the underlying mechanisms are not yet understood, preventing optimal clinical use of FLASH-RT. This proposal combines chemistry, in vitro and in vivo experiments with a multi-scale modeling approach from the DNA scale up, to determine the mechanisms of FLASH-RT.

PI_NAMEs: SCHUEMANN, JAN PATRICK OSCAR (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: Animal Model;Biological Assay;Brain;Brain Glioblastoma;Breathing;Cells;chemical kinetics;Chemical Models;chemical reaction;Chemicals;Chemistry;Clinic;Clinical;Clinical Trials;Collaborations;Complex;conventional dosing;Cranial Irradiation;Cutaneous Lymphoma;Data;Daughter;DNA;DNA Damage;DNA Repair;Dose;Dose Rate;dosimetry;Electrons;Ensure;experimental study;Fractionation;Human;Hydrogen Peroxide;improved;In Vitro;in vivo;Intestines;Iron;irradiation;Kinetics;Lesion;Measures;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Bone;Modeling;multi-scale modeling;Mus;Normal tissue morphology;Outcome;Oxygen;Pathway interactions;Patient Recruitments;Patients;Phase;Physiologic pulse;Positron-Emission Tomography;pre-clinical;prevent;Process;Production;Protons;Pulse Rates;Radiation induced damage;Radiation therapy;Radiochemistry;Reaction;Safety;scale up;Schedule;side effect;simulation;Skin;stem;Structure;Sulfhydryl Compounds;Testing;Time;Tissue Therapy;Tissues;Translating;Translations;tumor;Tumor Tissue;Work

PROJECT_TITLE: Using experimentally-guided multi-scale modeling to determining the mechanism of FLASH tissue sparing


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This project aims to establish whether the mechanisms of alpha-range (8-12Hz) neural oscillations, robustly observed in human visual cortex, are strictly attentional or whether they reflect other mechanisms, such as local visual dynamics or system-wide alertness. We will record EEG and fMRI concurrently in human participants, and employ causal models, to identify functional connectivity of visual cortex during alpha modulations across different task contexts. The results will drive interpretation of alpha oscillations as a biomarker of attention-system efficacy in ADHD and related conditions, refining a model that can be targeted in treatment monitoring.

PI_NAMEs: LENARTOWICZ, AGATHA  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Accounting;Address;alertness;Architecture;Attention;Attention deficit hyperactivity disorder;Attentional deficit;Biological Markers;Brain;candidate marker;causal model;Cytology;Data;Disease;electrical potential;Electroencephalography;Experimental Models;experimental study;functional magnetic resonance imaging/electroencephalography;Goals;Human;innovation;Measures;memory process;Methods;Modality;Modeling;Monitor;neural;Neurocognitive;neurotransmission;Occipital lobe;Participant;Perception;Reporting;Research;Role;Scanning;selective attention;Short-Term Memory;Signal Transduction;Sleep;System;Technology;Testing;Visual;Visual Cortex;visual processing;Work

PROJECT_TITLE: Understanding the neurocognitive mechanisms of alpha-band brain oscillations using concurrent EEG-fMRI recordings

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE - Overall The vision of the UC Davis ADRC is to strive for a lifetime of brain health for all and our mission is to advance the science of healthy brain aging among diverse populations while caring for those affected by dementia. This vision and mission reflects the evolving needs of an increasingly older and more diverse US population. Moreover, while AD continues to be the major pathological cause of dementia, more recent studies find that dementia pathology is multifactorial and highly heterogeneous, due in part to the co-occurrence of AD and vascular disease, which varies by ethnoracial characteristics, is emphasized as part of dementia prediction and which can be modified by treatment even in later life.

PI_NAMEs: DECARLI, CHARLES  (contact);WHITMER, RACHEL A

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: Acceleration;Address;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Area;Autopsy;Awareness;Biological Markers;Blood;brain health;career;Caregiver research;caregiving;Caring;Characteristics;Charge;Clinical;Cognition;Cognitive;cohort;collaborative environment;Communities;Data;Database Management Systems;Databases;Dementia;dementia risk;design;Development;Diagnosis;Disease;Disparity;disparity reduction;Early Diagnosis;education research;Educational Status;effective therapy;Environment;epidemiology study;ethnic minority population;ethnoracial;Fostering;Funding;Future;Goals;Health Professional;Heterogeneity;high risk;Image;imaging biomarker;Impaired cognition;improved;Individual;innovation;insight;interdisciplinary collaboration;interest;International;Intervention;Investigation;late life;Measures;Mentors;Methods;Mission;neuropathology;next generation;novel;Outcome;Participant;Pathologic;Pathology;Persons;Phenotype;Population;Population Heterogeneity;prevent;Prevention;Prevention strategy;Qualifying;racial minority population;recruit;Research;Research Activity;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resources;Risk Factors;risk mitigation;Risk Reduction;Scanning;Science;Secure;Services;stem;Technology;therapy development;tool;Training and Education;training opportunity;Translational Research;Vascular Diseases;Vision;Walking

PROJECT_TITLE: UC Davis Alzheimer's Disease Research Center


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Caregiving Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: DECARLI, CHARLES  (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Advisory Committees;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Welfare;Annual Reports;Award;Basic Science;Behavioral Research;Biological Markers;Biomedical Research;Caregiver research;caregiving;caregiving research;Caring;Clinical Research;Cognitive;Cognitive aging;Collaborations;collaborative environment;Communication;community advisory board;community based research;complement resource;Data;data exchange;Data Set;Dementia;Development;Diagnosis;Disparity;Early Diagnosis;education research;Ensure;Environment;epidemiology study;ethnic minority population;Faculty;flexibility;Funding;Funding Agency;Future;Geography;Goals;Grant;Growth;Heterogeneity;high risk;human subject;Image;improved;Infrastructure;innovation;International;Leadership;Longevity;Mission;next generation;novel;Outcome;outreach;Participant;Pathology;Policies;Population Heterogeneity;prevent;Process;programs;racial minority population;recruit;Research;Research Personnel;Research Training;Resources;Risk Factors;risk mitigation;Sampling;Science;Scientist;Serum;Strategic Planning;study population;success;therapy development;Training;Training Programs;Translational Research;treatment strategy;undergraduate student;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This project will define biochemical and cellular mechanisms by which the innate immune kinase TBK1 promotes activation of the anabolic kinase mTOR. Through study of genetically modified mice, it will also advance our knowledge of how the TBK1-mTOR axis integrates innate immune and metabolic signals to attenuate obesity-linked insulin resistance and hyperglycemia, potentially revealing therapeutic opportunities to treat type II diabetes.

PI_NAMEs: FINGAR, DIANE C. (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Adipocytes;Adipose tissue;Agonist;Alleles;Amino Acids;Anti-Inflammatory Agents;Attenuated;Biochemical;blood glucose regulation;Catalytic Domain;Cell Physiology;Cells;Communication;Complex;Cues;Cultured Cells;cytokine;defense response;diet-induced obesity;Dimerization;Disease;Double-Stranded RNA;EGF gene;energy balance;FRAP1 gene;Gene Modified;Genes;glycemic control;Goals;Growth Factor;Homeostasis;Hormones;Host Defense;Hyperglycemia;IL10 gene;Immune;immune function;Immune response;Immune System Diseases;improved;in vivo;Infection;Inflammation;Inflammatory;Insulin;Insulin Resistance;insulin sensitivity;Interferon Type I;Interferon-beta;Interferons;Interleukin-10;Knock-in;Knock-out;Knowledge;Lead;Link;Macrophage;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;microbial;mimetics;Molecular;Mus;Myelogenous;Myeloid Cells;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Obese Mice;Obesity;pathogenic bacteria;pathogenic virus;Pathologic;Phagocytes;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;Poly I-C;Prevalence;Process;Production;Proteins;Regulation;Resistance;response;Role;Signal Transduction;Site;Stimulus;System;TANK-binding kinase 1;Testing;Therapeutic;Thinness;tumorigenesis;Viral;Work

PROJECT_TITLE: Regulation and function of TBK1-mTOR crosstalk

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This proposal explores the basic mechanisms whereby members of the Bacillus cereus sensu lato group cause gastrointestinal anthrax, a lethal disease that affects all mammals. Host-pathogen interactions are studied in the context of the unusual lifestyle of these spore-forming bacteria and their unique envelope. Results from these studies are expected to be broadly informative for the appreciation of gastrointestinal infections by invasive pathogens.

PI_NAMEs: MISSIAKAS, DOMINIQUE M. (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Adhesions;Affect;Alveolar Macrophages;Animals;Anthrax disease;Anti-Bacterial Agents;Attenuated Vaccines;Bacillus;Bacillus anthracis;Bacillus anthracis spore;Bacillus cereus;Bacteria;Bacterial Adhesins;base;Binding;Biochemical;bioweapon;Candidate Disease Gene;Carbohydrates;Cavia;Cell Communication;Cell Cycle;cell growth;Cell membrane;Cell Wall;Cells;Collection;Communicable Diseases;Complex;Consumption;Cultured Cells;Cutaneous;Data;Dendritic Cells;Disease;Edema;Enabling Factors;Environment;Enzymes;Epithelium;Food Contamination;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Genes;Germination;glycosyltransferase;Goals;Gram-Positive Bacteria;Growth;guinea pig model;Host Defense;Human;Hydrolase;Immunocompetent;Infection;Infectious Diseases Research;Ingestion;Inhalation;Insecta;Integrins;Intercellular Junctions;intestinal epithelium;Intestinal Mucosa;Intestines;Invaded;Kinetics;knockout animal;Length;lethal factor;Libraries;Life Style;Ligation;Link;Lung;Lymphatic System;Lymphoid Tissue;M cell;Mammals;Mediating;member;Membrane Proteins;Modeling;Molecular;monocyte;monolayer;mucinase;Mucins;Mus;mutant;Mutation;novel;Organism;Organoids;pathogen;Pathogenesis;Pathway interactions;Penetration;Peptidoglycan;Pharmaceutical Preparations;Physically Challenged;Plasmids;Polymerase;Polymers;Polysaccharides;Process;Proteins;Reproduction spores;Research;Resistance;respiratory;Route;Shapes;Site;Structure;Surface;Testing;Thick;transcytosis;Transferase;uptake;Virulence;Virulent;Viscosity

PROJECT_TITLE: Surface Proteins of Bacillus anthracis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Although intersectional stigma and discrimination are critical barriers to HIV care engagement among women living with HIV who use drugs (WLHIV-WUD) in the United States (US), there is a notable lack of interventions that draw upon intersectionality to optimize HIV care in this population. This study will examine how stigma and discrimination lead to intersectional inequalities in antiretroviral therapy adherence and viral suppression and explore how resilience promotes HIV care, to inform the systematic adaptation of an HIV-related evidence- based intervention to facilitate engagement in care among racially diverse WLHIV-WUD in the US. Findings from this research will advance HIV treatment and intervention science by applying an intersectional framework and approach to improve HIV treatment outcomes and promote intersectional equity among WLHIV-WUD through the delivery of specialized intervention strategies.

PI_NAMEs: JAIN, JENNIFER PAYAAL (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Anti-Retroviral Agents;antiretroviral therapy;Applied Research;arm;Award;Black race;career;career development;Caring;Cohort Studies;Data;Death Rate;Development Plans;Discrimination;Drug usage;Epidemic;Epidemiologic Methods;Equity;ethnoracial;Evidence based intervention;experience;Failure;Feedback;Focus Groups;Goals;Health;Health Personnel;Health Status;High Prevalence;HIV;HIV/AIDS;improved;Inequality;intersectionality;Intervention;Interview;knowledge base;Lead;Learning;Link;Manuscripts;Mediator;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Modeling;Monitor;Outcome;Persons;Pilot Projects;Population;post intervention;Process;promote resilience;prospective;Protocols documentation;Race;racial diversity;recruit;Reporting;Research;Research Support;resilience;Resources;response;San Francisco;satisfaction;Science;Scientific Advances and Accomplishments;skills;social stigma;Stigmatization;Structure;substance use;success;Surveys;System;Techniques;Testing;theories;therapy adherence;therapy design;Training;Training Activity;treatment as prevention;treatment optimization;Treatment outcome;United States;United States National Institutes of Health;Viral;Woman;women's prevention;Work;Writing

PROJECT_TITLE: Women, Intersectionality, Substance Use and HIV ( WISH)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: TOMASZEWSKI-FARIAS, SARAH E (contact)

PROJECT_TERMS: Acceleration;Affect;African American population;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Asian;Assessment tool;Autopsy;Awareness;Behavioral;Biological;Biological Markers;biomarker development;Black race;Blood;Brain;brain health;Brain imaging;brain magnetic resonance imaging;brain research;Caring;Cessation of life;Classification;Clinical;Clinical Data;clinical diagnosis;clinical diagnostics;Cognition;Cognitive;Cognitive aging;cohort;Collaborations;Collection;Communities;Complex;Consent;daily functioning;Data;Data Collection;Databases;Dementia;dementia risk;Development;Diagnosis;Diagnostic;Disease;DNA;Education;effective therapy;Enrollment;Epidemiology;epidemiology study;ethnic disparity;Ethnic Origin;experience;Exposure to;Family;follow-up;Goals;Heterogeneity;Hispanic Populations;Image;Immigration;Impaired cognition;Impairment;Individual;innovation;Interdisciplinary Study;Intervention Trial;Language;Latinx;Leadership;Life Cycle Stages;Longitudinal cohort;Measurement;Methods;Mission;modifiable risk;multidisciplinary;multiple data sources;neuroimaging;neuropathology;novel;older adult;Outcome;Pathology;patient engagement;Phenotype;Plasma;Population;Population Heterogeneity;Population Study;Positron-Emission Tomography;Prevalence;Prevention;protective factors;Protocols documentation;Psychometrics;Public Health;racial disparity;recruit;Research;Research Methodology;Research Personnel;Resources;Retrieval;Risk Factors;RNA;Sampling;Science;social;social culture;socioeconomics;Spanish/English;Specimen;Standardization;success;Training;Translating;Translational Research;Underrepresented Populations;underserved community;vascular contributions;Vascular Diseases;vascular risk factor;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Precision Medicine

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative NEUFIN (Neuroscience in First Nations) is a unique advanced research training and mentoring program focused on the indigenous minorities of South America, one of the most underserved populations in the globe. Over the past five years we completed two cycles of advanced training -in the context of an international master of science degree - and capacity development, for scholars and faculty of First Nations from Bolivia, Peru and Argentina. We will continue to build capacity and train Quechua neuroscientists on clinical research applications of neuroimaging, genetics, epidemiology, neuropsychology and neuromodulation. We will also create personalized training environments and an innovation ecosystem online to support capacity and career development for Quechua neuroscientists after completion of their initial degree.

PI_NAMEs: DE ERAUSQUIN, GABRIEL ALEJANDRO (contact)

PROJECT_TERMS: Andean;Argentina;Behavior Disorders;Bolivia;Brain Diseases;career development;Chronic;Clinical;Clinical Research;Collaborations;Communities;Country;Development;Doctor of Philosophy;Ecology;Ecosystem;Educational Curriculum;Electronic Mail;Enrollment;Ensure;Environment;Epidemiology;experience;Faculty;falls;Funding;Genetic;Genetic Research;Grant;Health;Home;Image;Incentives;Indigenous;innovation;Institution;Interdisciplinary Study;International;Learning;Master of Science;medical schools;Mentors;Mentorship;Minority;model building;multidisciplinary;Multiple Partners;Neurodegenerative Disorders;neuroimaging;neuropsychiatric disorder;neuropsychiatry;Neuropsychology;neuroregulation;Neurosciences;online resource;Online Systems;personalized learning;personalized medicine;Peru;Pilot Projects;precision medicine;programs;Quechua;recruit;Research;Research Institute;Research Personnel;research study;Research Training;Rotation;Scholarship;Scientist;Series;South America;South American;System;Texas;tool;Training;Training Programs;translational medicine;translational neuroscience;Translational Research;Underserved Population;Universities;Washington;Work

PROJECT_TITLE: Multidisciplinary Training Program on Neuropsychiatry and Behavioral Disorders in First Nations (NEUFIN)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: HARVEY, DANIELLE  (contact)

PROJECT_TERMS: Alzheimer's Disease;analytical method;Architecture;Area;Biological Markers;biomarker development;Biostatistical Methods;Blood;Characteristics;Clinical;Clinical Data;clinical diagnosis;Clinical Research;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Collaborations;Communities;Complex;Computer Systems;computerized data processing;Data;data access;Data Collection;data framework;data integration;data management;Data Management Resources;data portal;data quality;Data Security;Data Set;data sharing;Databases;Dementia;design;Development;Disease;Disease Progression;dynamic system;Education;education research;electronic data;electronic data capture system;endophenotype;Enrollment;epidemiology study;Faculty;follow-up;Goals;graduate student;healthy aging;Heterogeneity;high dimensionality;Histology;Image;Impaired cognition;Impairment;improved;Individual;Infrastructure;innovation;International;Internet;Java;Lead;Leadership;Life Cycle Stages;longitudinal analysis;Longitudinal cohort;Measures;meetings;Mentors;Methodology;Modeling;Monitor;multi-ethnic;neuroimaging;neuropathology;next generation;Non-linear Models;novel;Online Systems;Onset of illness;operation;outreach;Pathogenesis;Pathology;Physiological;Population Heterogeneity;Postdoctoral Fellow;Procedures;Process;Qualifying;Quality Control;recruit;Reporting;Reproducibility;Research;Research Design;research faculty;Research Personnel;resilience;Resources;Risk Factors;Sampling;Science;Secure;Source;Statistical Methods;statistics;Summary Reports;System;Techniques;Time;tool;Training;undergraduate student;user-friendly;web app;web based interface

PROJECT_TITLE: Data Management and Statistical Core


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Substance Misuse

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE Pain is a common, highly distressing symptom for patients hospitalized in comprehensive rehabilitation that may disrupt recovery and rehabilitative efforts (e.g., avoidance of physical therapy). Narcotic treatment is an option for severe pain, but side effects and risk of addiction prevent its long-term use. Using quantitative and qualitative methods, this project will assess the feasibility and acceptability of a pharmaco-behavioral intervention for pain by applying principles of classical conditioning and open-label placebo among hospitalized patients and will inform the science of managing pain and their clinical consequences amongst medical populations more broadly.

PI_NAMEs: MORALES-QUEZADA, JORGE LEON (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Absence of pain sensation;acceptability and feasibility;addiction;Adverse effects;Analgesics;Association Learning;Attitude;Behavior Therapy;Behavioral;Behavioral Paradigm;behavioral pharmacology;Belief;Biological Markers;Burn injury;career;career development;Clinical;clinical effect;clinical pain;clinical training;Clinical Trials;Clinical Trials Design;Conditioned Stimulus;conditioning;Coupled;Data;Data Analyses;Data Collection;debilitating pain;design;Development;Distress;dosage;Dose;Electroencephalography;Enrollment;Environment;Ethics;Evaluation;evidence base;expectation;functional near infrared spectroscopy;Funding;Goals;health care service utilization;Healthcare;Hospitalization;Injury;innovation;Inpatients;Institution;Intervention;Interview;Investigation;Irritable Bowel Syndrome;Journals;K-Series Research Career Programs;Learning;Link;longitudinal analysis;Low Back Pain;Measurement;Medical;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic Activation;Methods;multimodality;Multiple Trauma;Narcotics;neurophysiology;novel;open label;Opioid;opioid use;Outcome;Pain;pain behavior;Pain management;pain outcome;pain relief;Patients;Pattern;Peer Review;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;Physical Medicine;Physical therapy;pill;Pilot Projects;Placebo Effect;Placebos;Population;Positioning Attribute;Prevalence;prevent;Procedures;Publishing;Qualitative Methods;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Research Training;Resources;response;Risk;Science;side effect;Signal Transduction;Spinal cord injury;standard care;Stimulus;symposium;symptom management;Symptoms;Techniques;Testing;Training

PROJECT_TITLE: Opioid Dose Reduction in Comprehensive Inpatient Rehabilitation: A pharmaco-behavioral approach

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: DUGGER, BRITTANY NICOLE (contact)

PROJECT_TERMS: African American;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Applications Grants;Asian;Autopsy;Basic Science;biobank;Biological;biological heterogeneity;Biological Markers;Brain;Brain Diseases;Brain imaging;Brain Injuries;brain tissue;career;cerebrovascular;Clinic;Clinical;clinical heterogeneity;Clinical Pathology;Cognitive;cognitive ability;cognitive testing;cohort;Collaborations;Complex;Consensus;Data;data integration;Data Set;Dementia;dementia risk;Detection;Diagnosis;diagnostic value;digital pathology;Disease;Education;Education and Outreach;Educational Activities;experience;Faculty;Fostering;Funding;Future;General Population;Goals;Grant;Heterogeneity;Hispanic;Image;Impaired cognition;Individual;Infrastructure;Injury;Interdisciplinary Study;Intervention;Journals;Knowledge;Latino;Leadership;Link;Longitudinal cohort;Machine Learning;Medical Staff;meetings;member;Methods;Minority;Mission;Modernization;Molecular;multi-ethnic;neuropathology;novel;older adult;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Play;Predictive Value;Prevention;Process;Prognosis;Publications;Qualifying;Race;Reporting;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Risk Factors;Role;Sampling;Scientist;Services;Societies;Specimen;Standardization;Students;Study Subject;symposium;System;Techniques;Technology;Tissue Banks;Tissue Sample;Tissues;tool;Training;Translating;Translational Research

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSON, DAVID K (contact)

PROJECT_TERMS: Advocacy;Affect;African American;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Awareness;Back;Biological Markers;Black Populations;Black race;California;Caring;Catalogs;Clinical;Clinical Research;Cognitive;cohort;Collaborations;Color;Communities;Community Actions;community advisory board;community based participatory research;community based research;community engagement;community partners;Complex;Consent;coping;Cultural Backgrounds;Dementia;demographics;design;Detection;Diagnosis;digital;digital media;digital platform;disability;Disease;disease classification;disease phenotype;Disparity;Economics;Education;Educational Background;efficacious treatment;Elderly;Environment;Equity;ethnoracial;Event;experience;Facebook;Family;Gender;Goals;Health education;Healthcare;Heterogeneity;Hispanic;hispanic community;Hispanic Populations;Impaired cognition;Incentives;indexing;Individual;innovation;interest;Knowledge;Life Experience;Loneliness;Marketing;minority communities;Minority Recruitment;Nature;Newsletter;Not Hispanic or Latino;novel;older adult;Older Population;outreach;Participant;patient engagement;Persons;Phenotype;Population;Population Heterogeneity;Prevalence;Prevention strategy;Process;programs;Proxy;Public Health;Race;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Services;Severity of illness;social;social determinants;social media;socioeconomics;tailored messaging;Time;tool;treatment strategy;trend;Underrepresented Populations;urban setting;Variant;Vision

PROJECT_TITLE: Outreach, Recruitment and Engagement Core


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE CRISPR-Cas systems have been developed into genome editing technologies that are revolutionizing biomedical research and clinical applications. Our proposed studies aim to understand the structure and molecular basis of newly discovered type V and transposon-associated CRISPR-Cas systems that could be used to overcome challenges and limitations of current tools. 1

PI_NAMEs: CHANG, LEIFU  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: adaptive immunity;Adopted;Archaea;Bacteria;Base Pairing;Binding;Biochemical;Biological Assay;Biomedical Research;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;complex data;Coupled;CRISPR-associated transposons;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Deoxyribonucleases;Dependence;Development;DNA;DNA Integration;DNA Repair;DNA Repair Pathway;ds-DNA;endonuclease;Family;Genetic;Genome;genome editing;Goals;Guide RNA;Heteroduplex DNA;human disease;improved;In Vitro;insight;Knowledge;Life;Mediating;Mobile Genetic Elements;Molecular;Mutation;Nature;novel;Nucleic Acid Cleavage;Nucleic Acids;particle;Plasmids;precise genome editing;Process;Proteins;recruit;Resolution;Ribonucleases;RNA;RNA Editing;RNA Processing;RNA Sequences;Safety;Site-Directed Mutagenesis;Specificity;Structural Models;Structure;System;targeted nucleases;Technology;Testing;thermostability;tool;Transposase;virtual;Virus;Work

PROJECT_TITLE: Molecular basis for CRISPR RNA-guided nucleic acid cleavage and DNA transposition

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Glucagon and insulin are considered to be opposing factors for regulating glucose metabolism, yet they are co- secreted in response to a mixed nutrient meal. Our preliminary data suggests that glucagon and insulin coordinate, rather than oppose, each other to regulate hepatic glycogen metabolism. In this proposal, we will test the hypothesis that glucagon and insulin generate a unique hepatic signature that leads to optimal systemic glucose utilization.

PI_NAMEs: CAPOZZI, MEGAN  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Amino Acids;Anabolism;Attention;Automobile Driving;B-Lymphocytes;Beta Cell;Blood Glucose;blood glucose regulation;Bypass;Carbon;career;Cells;Circulation;Consensus;Data;Development;Fasting;Fatty Acids;feeding;Foundations;genetic manipulation;GLP-I receptor;Glucagon;Gluconeogenesis;Glucose;glucose metabolism;glucose tolerance;glucose uptake;glycemic control;Glycogen;glycogen metabolism;glycogenolysis;Hepatic;Hepatocyte;Homeostasis;Hormones;Human;Hypoglycemia;Individual;Ingestion;insight;Insulin;insulin secretion;insulin signaling;islet;Islets of Langerhans;Liver;Liver Glycogen;liver metabolism;Maintenance;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Diseases;Modeling;mouse model;Mus;new therapeutic target;Nutrient;Obesity;Pancreatic Hormones;Peripheral;phosphoproteomics;Physiological;Plasma;prevent;Regulation;Research Personnel;response;Rodent;Role;Signal Pathway;Signal Transduction;Stimulus;Testing;Tissues;Tracer;Work

PROJECT_TITLE: Glucagon and insulin act cooperatively in the regulation of prandial hepatic glycogen metabolism


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The University of Minnesota Duluth in collaboration with Fond du Lac Tribal and Community College and Lake Superior College will provide training to rural, low income and underserved minorities to expand and diversify the national pool of biomedical research professionals. Bridges trainees will gain knowledge and develop skills to participate in biomedical research to understand human disease and to develop efficacious cures.

PI_NAMEs: CLARKE, BENJAMIN L (contact);WILCOX, TERRENCE ;WOLD, ANDREW

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academic advising;Academic support;Active Learning;Aptitude;Award;Bachelor's Degree;Biomedical Research;biomedical scientist;bridge to the baccalaureate;candidate identification;career;Collaborations;college;community college;Community Outreach;Critical Thinking;Development;Discipline;Enrollment;experience;faculty mentor;Financial Support;Fond du Lac Tribal and Community College;Future;Goals;Institution;Learning;medical schools;Mentors;Minnesota;Mission;Outcome;programs;Research;Research Training;Resources;Science;Scientist;Students;tool;Training Programs;Underserved Population;Universities;university student;Vocational Guidance

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at the University of Minnesota Duluth

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: JIN, LEE-WAY  (contact)

PROJECT_TERMS: accurate diagnosis;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Bar Codes;biobank;Biological;Biological Markers;biomarker discovery;Blood;Blood specimen;blood-based biomarker;Brain Injuries;career development;Categories;Clinical;clinical epidemiology;Clinical Trials;Cognitive;Cognitive aging;cohort;Collaborations;Collection;Communities;Complex;Computer software;cost efficient;Data;data sharing;Databases;Dementia;Deposition;Diagnostic;Disease;DNA;Epidemiology;epidemiology study;Equipment and supply inventories;Faculty;Freezing;frontier;Funding;Genetic;glycoproteomics;Goals;Grant;Heterogeneity;Impaired cognition;indexing;Individual;Infrastructure;innovation;Intervention;Life;lipidomics;Longitudinal cohort;Mentors;metabolomics;multi-ethnic;multiple omics;neuroimaging;neuropathology;novel marker;older adult;operation;Outcome;Pathologic Processes;Pathology;Phenotype;Plasma;Population Heterogeneity;Procedures;Process;programs;protein biomarkers;Qualifying;Race;Regulation;repository;Research;research and development;Research Personnel;Resources;response;Retrieval;risk prediction model;RNA;saliva sample;sample collection;Sampling;Secure;Serum;specific biomarkers;Specimen;Standardization;standardize measure;Study Subject;System;tau Proteins;tau-1;Technology;Time;tool;Validation;web based interface;web portal;Work

PROJECT_TITLE: Biomarker Core


ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed research is relevant to public health because it focuses on discovery of novel signaling pathways that drive castration-resistant prostate cancer. These studies will establish new avenues of investigation to develop improved therapeutics to treat this deadly disease and to greatly improve patient outcome. Thus, the proposed research is relevant to NCI's mission of fostering creative discoveries and innovative research strategies for protecting and improving health and reducing the burdens associated with cancer.

PI_NAMEs: LIU, XIAOQI  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: abiraterone;Affect;androgen independent prostate cancer;Androgen Receptor;Androgens;ataxia telangiectasia mutated protein;Biochemical;Biological Markers;brca gene;BRCA mutations;cancer cell;Cancer Patient;Castration;Cell Culture System;Cells;Chromatin;Clinic;Clinical;Clinical Research;Clinical Trials;clinically relevant;comparative efficacy;Complex;Creativeness;cytotoxic;Data;Defect;design;Development;Disease;DNA amplification;DNA Damage;DNA damage checkpoint;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;DNA Repair Pathway;efficacy evaluation;enzalutamide;Event;Exhibits;Fostering;Frequencies;genetic approach;Genetically Engineered Mouse;Goals;Health;improved;inhibitor;innovation;Investigation;Ionizing radiation;Malignant neoplasm of prostate;Malignant Neoplasms;Mediator;Meiotic Recombination;Mission;Mitotic;mouse model;Mus;Mutation;novel;novel strategies;Outcome;overexpression;patient population;Patient-Focused Outcomes;Patients;Phosphorylation;Phosphotransferases;PLK1 gene;Poly(ADP-ribose) Polymerase Inhibitor;premature;Prognostic Marker;prostate cancer cell;prostate cancer progression;Proteins;Public Health;Receptor Signaling;Recovery;Research;Resistance;response;Role;Sampling;Signal Pathway;Signal Transduction;success;Testing;Therapeutic;tumor;Tumor Subtype;Withdrawal;Work

PROJECT_TITLE: Plk1 as a prognostic biomarker for prostate cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


PHR: PROJECT NARRATIVE Proper cell shape control is essential for the proliferation of cells, normal development and maintenance of a healthy organism. We study how cytokinesis, the physical process in which one cell splits into two, works at a fundamental level in order to understand how cells control cell shape more generally. Ultimately, with a rigorous understanding and a complete molecular handle on these processes, it should be possible to develop better therapies that are tailored to the properties of specific disease types.

PI_NAMEs: ROBINSON, DOUGLAS N (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Actins;Actomyosin;Adenine Nucleotide Translocase;Affinity;Area;Binding;Biochemical;Biological Assay;Biology;Biomechanics;Bypass;cell behavior;cell cortex;Cell model;Cell Physiology;Cell Proliferation;Cell Shape;Cells;cellular imaging;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal Cancer;Complex;cortexillin I;Crosslinker;crosslinking and immunoprecipitation sequencing;Cytokinesis;Cytoplasm;Cytoprotection;Cytoskeletal Proteins;Cytoskeleton;Data;daughter cell;Development;Dictyostelium;Dictyostelium discoideum;Diffusion;Disease;Endowment;Engineering;Environmental Hazards;Exposure to;Feedback;Filament;Fluorescence;follow-up;Gene Expression;Genetic;Grant;Hepatocyte;Human;In Vitro;in vivo;individualized medicine;KIT gene;knock-down;Lectin;Length;Life;Link;Liquid substance;Lung;Maintenance;Malignant neoplasm of pancreas;Mammalian Cell;Maps;Measurement;Mechanical Stress;Mechanics;Messenger RNA;Metabolic;Metabolism;Microtubules;Molecular;mRNA Stability;mutant;Myoblasts;Myosin Type II;Nocodazole;Organism;Outcome;overexpression;Oxidative Phosphorylation;Pathway interactions;Phenotype;physical process;Process;Production;Property;Protein Secretion;Proteins;Proteomics;Race;reconstitution;Ribonucleoproteins;RNA;RNA Recognition Motif;RNA-Binding Proteins;Role;Signal Transduction;single molecule;Site;small molecule;Spectrum Analysis;stoichiometry;Surface;Surveys;System;Techniques;Transcript;transcriptome sequencing;viscoelasticity;Work

PROJECT_TITLE: The Biochemical Basis for the Mechanics of Cytokinesis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: FAN, AUDREY PEIWEN (contact)

PROJECT_TERMS: Aging;aging biomarker;aging brain;Alzheimer's Disease;Amyloid;Archives;Autopsy;Back;Biological Markers;Biomedical Engineering;Brain;Brain imaging;Brain Injuries;Clinical;Cognition;Cognitive;cognitive change;cohort;Collaborations;Communities;Complement;Computer software;Computer Systems;computerized data processing;Country;Data;Data Analyses;data management;Databases;Dementia;Diagnostic;Dimensions;Disease;Education;education research;experience;Faculty;faculty mentor;Framingham Heart Study;Funding;Goals;Grant;Human;Image;image processing;imaging biomarker;improved;Institution;International;Intuition;investigator training;kinetic model;Life;life span;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Medical center;method development;Methods;Mission;MRI Scans;neuroimaging;neuropathology;normal aging;novel;Nuclear Pore Complex;outreach;Play;Positioning Attribute;Positron-Emission Tomography;Postdoctoral Fellow;Privatization;Process;Quality Control;recruit;Research;research clinical testing;Research Personnel;Research Project Grants;Research Support;Resources;Role;Scanning;Scientist;Secure;Services;statistics;Structure;Students;success;System;Techniques;Tracer;Training;usability;Vascular Diseases;Work

PROJECT_TITLE: Neuroimaging Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Disability Research;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Patient Safety;Precision Medicine;Prevention;Serious Mental Illness

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Major depressive disorder (MDD) is a chronic, recurrent illness impacting more than a fifth of the U.S. population and causing significant disability and economic impacts annually. Antidepressants are a first-line depression treatment taken by 70% of patients with depression, yet 50% of patients taking an antidepressant continue to experience significant depressive symptoms, creating an urgent need to identify patients at risk for inadequate antidepressant response early to reduce MDD chronicity, disability, and costs. This study aims to 1) develop a predictive model from clinical and demographic data identifying patients at risk for inadequate antidepressant response at first clinical presentation for depression using predictive modeling and machine learning approaches, 2) examine how genetic and behavioral data enhance clinical prediction models, and 3) evaluate barriers and facilitators of predictive models for depression into clinical practice.

PI_NAMEs: ERICKSON-RIDOUT, KATHRYN KELLY (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Address;Age;anti-depressive agents;Behavioral;California;Characteristics;Chronic;chronic depression;Clinical;clinical application;clinical decision support;clinical decision-making;clinical development;clinical implementation;clinical practice;clinical predictive model;clinical translation;cohort;comorbidity;Consolidated Framework for Implementation Research;cost;Data;Data Set;Decision Making;depression model;depressive symptoms;disability;disability impact;Discrimination;Dose;economic impact;effective therapy;Electronic Health Record;Environment;Ethnic Origin;experience;Feedback;Female;Functional disorder;Gender;Genes;Genetic;Genetic Risk;genome-wide;Genotype;Goals;Guidelines;Health;Illness impact;implementation tool;improved;Individual;innovation;insight;Integrated Health Care Systems;Intervention;Knowledge;low socioeconomic status;machine learning prediction;machine translation;Major Depressive Disorder;Medical;member;Mental Depression;Mental Health;Methods;model generalizability;Modeling;National Institute of Mental Health;novel;Outcome;outcome prediction;Patient Care;Patients;Perception;personalized intervention;Population;Population Heterogeneity;Predictive Factor;predictive modeling;predictive tools;prevent;programs;prospective;Provider;psychiatric comorbidity;public health relevance;Questionnaires;racial minority;Recommendation;Recurrence;reduce symptoms;Research;Research Personnel;response;Risk;Risk Factors;risk prediction model;risk stratification;single episode major depressive disorder;statistics;Strategic Planning;suicidal;Symptoms;Testing;Time;tool;Trauma;treatment and outcome;treatment optimization;Treatment outcome;treatment strategy;Unemployment;Validation;Washington

PROJECT_TITLE: Computational Strategies to Tailor Existing Interventions for First Major Depressive Episodes to Inform and Test Personalized Interventions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: MEYER, OANH L (contact)

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Basic Science;Behavioral;Brain imaging;career;career development;Caring;Clinical;Clinical Sciences;Cognitive;cognitive change;Cognitive Science;Collaborations;Coupled;Creativeness;Dementia;Development;Diagnosis;Discipline;Disease;Disparity;disparity elimination;early-career faculty;Education;education research;Ensure;Environment;ethnic diversity;ethnic minority;Evaluation;Evaluation Research;experience;Faculty;Family Caregiver;family support;Funding;Future;Goals;graduate student;Health;Impaired cognition;improved;Incidence;Individual;Infrastructure;Infusion procedures;innovation;insight;Interdisciplinary Study;interest;Intervention Studies;K-Series Research Career Programs;Knowledge;Leadership;Measures;Memory;Mentors;Mentorship;Mission;modifiable risk;Monitor;neuropathology;next generation;older adult;Older Population;outreach;Persons;Population Heterogeneity;Postdoctoral Fellow;Prevalence;prevent;programs;protective factors;racial diversity;racial minority;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Risk Factors;San Francisco;Science;Scientist;skills;Social Sciences;Structure;symposium;therapy development;Training;Training and Education;training opportunity;Travel;Underrepresented Populations;United States National Institutes of Health;Wages;Work

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE MPIs: de las Fuentes, Lisa; Davila-Roman, Victor G.; Málaga, German; Hartinger, Stella D43 Project Title: “Research Training: Chronic Non-communicable CVDs and Comorbidities in Peru” Project start / end: 9/1/2021-8/31/2026 Chronic non-communicable cardiovascular disease (CVD) and CVD co-morbid conditions are responsible for high morbidity and mortality in Peru. This D43 training program, led by two US institutions (Washington University in St. Louis, MO and Johns Hopkins University in Baltimore, MD) in coordination with 2 academic Peruvian institutions (Universidad Peruana Cayetano Heredia in Lima and Universidad Nacional del Altiplano de Puno (UNAP); and a Peruvian NGO in Lima and Puno (AB PRISMA), will develop a comprehensive research training program with the objective of preparing the next generation of Peruvian researchers to conduct high-quality, independent research on chronic CVD across the lifespan in Peru.

PI_NAMEs: DAVILA-ROMAN, VICTOR G.;DE LAS FUENTES, LISA  (contact);HARTINGER, STELLA MARIA

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Area;Awareness;Baltimore;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;career;Career Mobility;Chronic;Collaborations;comorbidity;design;Discipline;Disease;Dissemination and Implementation;Doctor of Philosophy;Environmental Exposure;Evidence based intervention;Faculty;Fogarty International Center;Foundations;Funding;German population;global health;Goals;Grant;Health Professional;Healthcare;High Prevalence;Hypertension;implementation science;improved;Institution;International;Intervention;Leadership;low and middle-income countries;low socioeconomic status;Mentors;multidisciplinary;National Heart, Lung, and Blood Institute;National Institute of Environmental Health Sciences;National Institute of Neurological Disorders and Stroke;National Institute on Aging;Peru;Peruvian;Policies;Postdoctoral Fellow;programs;Public Health;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Risk Factors;Scientist;Secure;skills;social factors;Stroke;Structure;Training;Training and Infrastructure;training opportunity;Training Programs;Translations;United States National Institutes of Health;Universities;Washington


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is a large and growing public health problem, especially for people with HIV (PWH). Within Kaiser Permanente, we use a syndemic approach to investigate combinations of social and biological conditions that may act synergistically to increase risk for of CVD in PWH, with a focus on the understudied conditions of mental health, substance use, economic factors, social isolation, stigma/discrimination, trauma history, and healthcare access challenges. Study findings have potential to identify community- and health system-based CVD prevention interventions for vulnerable PWH.

PI_NAMEs: SATRE, DEREK D;SILVERBERG, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: EINHORN, PAULA T

PROJECT_TERMS: Address;Age;Alcohols;Anti-Retroviral Agents;antiretroviral therapy;Atrial Fibrillation;Biological;Biological Factors;Biological Markers;Biological Specimen Banks;Body Weight;burden of illness;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Cardiovascular system;care systems;Cessation of life;cohort;Communities;comparison group;Coronary;Data;Data Sources;deprivation;design;Development;Discrimination;Disease;Disease Outcome;Disease Progression;Disparity;Dyslipidemias;Economic Conditions;Economic Factors;Electronic Health Record;Emotional;Enrollment;Evaluation;Event;follow-up;Functional disorder;Future;GDF15 gene;General Population;Geography;Goals;Health;health care availability;health care disparity;Health Services Accessibility;Health system;Healthcare Systems;Heart failure;High Prevalence;high risk;HIV;HIV Infections;Homelessness;housing instability;immunodeficiency;Inflammation;inhibitor;Insurance Benefits;Integrase;Intervention;Interview;Joints;Knowledge;Link;marginalized population;Measures;men;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;Neighborhoods;Obesity;Older Population;Patients;Peripheral arterial disease;Persons;Population;preventive intervention;pro-brain natriuretic peptide (1-76);Public Health;Recording of previous events;recruit;Research;Resources;response;revascularization;Risk;Risk Factors;Sampling;Smoking;social;Social Conditions;social factors;Social isolation;social relationships;social stigma;Stigmatization;Stroke;substance use;Substance Use Disorder;Surveys;syndemic;synergism;Toxic effect;Trauma;treatment disparity;Vulnerable Populations;Woman

PROJECT_TITLE: Assessing Syndemics of Cardiovascular Disease in People with and without HIV


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Projective Narrative  C. difficile infection is the most common nosocomial infection in the US. IL-6 is highly upregulated in patients with severe C. difficile infection (CDI) pathology and in CDI murine models. Our preliminary data suggests that IL-6 has a protective role against CDI disease progression and this work will determine the mechanism by which IL-6 can alter CDI pathology and explore the therapeutic potential of targeting this axis.

PI_NAMEs: TYUS, DAVID  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adrenergic Agents;alpha-adrenergic receptor;Anti-Inflammatory Agents;Antibiotics;Antiinflammatory Effect;Attention;Binding;Bone Marrow;Catecholamines;Cells;Cessation of life;Chimera organism;Clinical;Clostridium difficile;Communicable Diseases;Data;diarrheal disease;Disease;Disease Progression;Elderly;enteric infection;Epinephrine;Epithelium;epithelium regeneration;experimental study;Fortification;Functional disorder;Genetic Transcription;Gram-Positive Bacteria;gut microbiota;Hematopoietic;Immune;Immune response;Immunity;Immunophenotyping;immunoregulation;Immunotherapy;Infection;Inflammation;Inflammatory;innovation;Interleukin-6;Macrophage;Mediating;Modeling;Monitor;mortality;mouse model;Mus;Neurotransmitter Receptor;neutralizing antibody;Norepinephrine;Nosocomial Infections;novel therapeutics;Outcome;pathogen;Pathogenesis;Pathology;Patients;Persons;pharmacologic;Production;Proteins;Receptors, Adrenergic, alpha-2;recurrent infection;regenerative;Regulation;Research;response;Risk;Role;Sanitation;Severities;Severity of illness;Signal Pathway;Signal Transduction;Source;Symptoms;Testing;Therapeutic;therapeutic evaluation;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: The Impact and Regulation of IL-6 in Clostridioides difficile Infection


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Glioblastoma is a devastating brain cancer that needs new treatment options because even with chemotherapy, radiation, and surgical resection, tumor recurrence almost always leads to death. Here we propose synergistic combination therapy that relies on optimized elution of chemotherapeutics from a nanofibrous controlled-release scaffold placed in the brain at time of surgery to remove the tumor.

PI_NAMEs: AINSLIE, KRISTY M (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Abbreviations;Affect;anti-cancer research;Area;Area Under Curve;biodegradable polymer;bioluminescence imaging;Blood;Blood - brain barrier anatomy;Blood capillaries;blood-brain barrier crossing;Brain;brain tissue;cancer cell;cancer invasiveness;cancer therapy;Carmustine;Cell Membrane Permeability;Cerebrospinal Fluid;Cessation of life;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;Combined Modality Therapy;Contralateral;controlled release;cytotoxic;Data;Dextrans;DNA Sequence Alteration;Dose;Dose Limiting;Doxorubicin;Drug Combinations;Drug Delivery Systems;Drug Formulations;Drug Kinetics;drug release kinetics;Drug usage;Excision;fabrication;flexibility;Genetic;Genetic Engineering;Genetically Engineered Mouse;Genotype;Gliadel;Glioblastoma;Glycolates;Histopathology;Hydrophobicity;Immunohistochemistry;Implant;improved;In Vitro;in vivo;indexing;Individual;interstitial;Intravenous;Isopropanol;Kinetics;Left;Location;Malignant neoplasm of brain;Malignant Neoplasms;Maximum Tolerated Dose;Modeling;Molecular Target;Morphology;mortality;mouse model;mTOR Inhibitor;Mus;Mutation;nanofiber;Nature;neural implant;novel;Nude Mice;Operative Surgical Procedures;Outcome;Paclitaxel;Pathologic;Patients;Penetration;Pharmaceutical Preparations;poly(lactic acid);polycaprolactone;Polyesters;Polymers;precision oncology;Predisposition;Primary Brain Neoplasms;Property;Radiation;Radiation therapy;rate of change;Recurrence;Recurrent tumor;Residual Cancers;Resistance;Role;scaffold;SDZ RAD;Solubility;standard of care;success;Surface;Surgically-Created Resection Cavity;targeted cancer therapy;temozolomide;Therapeutic;Thinness;Tight Junctions;Time;TNF-related apoptosis-inducing ligand;Toxic effect;Translating;tumor;Tumor Cell Invasion;tumor growth;Tumor Tissue;Xenograft procedure

PROJECT_TITLE: Tunable Temporal Drug Release for Optimized Synergistic Combination Therapy of Glioblastoma

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: RALEIGH

ORG_DEPT: MISCELLANEOUS

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Gene-environment interactions (GxE) are widespread and contribute to phenotypic variation, environmental response, and adaptation, but we do not understand how genetic differences between individuals cause GxE. My research will use genome sequence, gene expression, and phenotypic data from genetically diverse individuals and a range of real-world environments to understand how GxE occurs at different scales. This research will help us to predict phenotypes across broader ranges of environmental conditions and contribute to a better understanding of how organisms adapt to new or changing environments.

PI_NAMEs: GAGE, JOSEPH LEE (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Alleles;Automobile Driving;Binding;Complex;Data;Data Set;Environment;experimental study;gene environment interaction;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene expression variation;gene regulatory network;Genes;Genetic;Genome;genome-wide;genomic predictors;Genotype;Individual;laboratory experiment;Modeling;Molecular;Nutrient;Organism;Pattern;Personal Satisfaction;Phenotype;phenotypic data;Population;predictive modeling;Research;response;Stress;Testing;Tissue Sample;trait;transcription factor;Variant

PROJECT_TITLE: Characterizing and modeling the genomewide molecular basis of gene-environment interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

PHR: Project Narrative This project addresses a gap in the training of the biomedical research workforce by providing early-career investigators with the leadership and management skills needed to foster research rigor, reproducibility, and transparency, responsible conduct of research, and supportive, inclusive research environments. The proposed program provides an innovative training course and peer mentoring to develop practical professional skills that will enable early-career researchers' success.

PI_NAMEs: ANTES, ALISON L (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Address;Adopted;Adoption;Advisory Committees;Affect;Awareness;Behavior;Biology;Biomedical Research;career;Career Choice;career development;Career Mobility;cohort;Communities;Data;Decision Making;design;Development;diversity and inclusion;E-learning;early experience;early-career faculty;Education;education research;educational atmosphere;Educational Curriculum;Effectiveness;Enrollment;Ensure;Environment;Evaluation;evidence base;experience;Faculty;faculty mentor;Feedback;Focus Groups;follow-up;formative assessment;Fostering;Funding;Goals;improved;Individual;Industrial Psychology;Industry;innovation;Institution;Instruction;Laboratories;Laboratory Research;Lead;Leadership;leadership development;Learning;learning outcome;learning strategy;Manuals;Measures;member;Mentors;Methods;model design;novel;novel strategies;Online Systems;Output;outreach;outreach program;Participant;pedagogical content;peer;peer coaching;peer learning;pilot test;Practice Management;preference;Productivity;professional atmosphere;programs;Psychology;Reaction;recruit;Reproducibility;Research;Research Ethics;Research Personnel;Resources;responsible research conduct;Science;Scientist;skills;success;tool;Training;Training Programs;Underrepresented Populations;United States National Institutes of Health;Workplace

PROJECT_TITLE: Program for Advancing Early-Career Researcher Excellence through Leadership and Management Practices


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Physical Activity

ORG_CITY: OMAHA

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Walking-induced claudication afflicts 5% of the US population older than 55 years of age and develops along with hardening of the arteries of the legs. Claudicating patients limp and can walk only very short distances because their leg muscles are damaged, and their legs hurt. Our protocol evaluates a mechanism believed by many to produce leg muscle damage and dysfunction of claudication and its successful completion can confirm this mechanism and yield a new treatment for the care of these patients.

PI_NAMEs: PIPINOS, IRAKLIS ILIAS (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: adduct;Affect;Age;Age Years;Agreement;Aldehydes;Antioxidants;Arteries;Brain Hypoxia-Ischemia;Caring;Cilostazol;claudication;Clinic;Clinical;Clinical Research;Cross-Over Studies;Development;Disease;DNA;Dose;Drug Targeting;Elderly;Electron Transport;Electrons;Endothelium;Exercise;FDA approved;Fibrosis;Functional disorder;Gait abnormality;Heme;hemodynamics;Histopathology;Hydrogen Peroxide;Hydroquinones;Hydroxyl Radical;Hypoxia;Impairment;improved;Individual;Inflammation;Inner mitochondrial membrane;Ischemia;Leg;Lipid Peroxidation;Lipids;Long-Term Effects;Lower Extremity;Lung;Measurement;metabolic profile;Mitochondria;mitochondrial membrane;Molecular;Muscle;Muscle Mitochondria;Myalgia;Myopathy;NADH dehydrogenase (ubiquinone);Older Population;Oral;oxidation;oxidative damage;Oxidative Phosphorylation;Oxygen;Pain in lower limb;pain relief;Participant;Pathologic;Pathology;Patients;Pentoxifylline;Performance;Peripheral arterial disease;Pharmaceutical Preparations;Physical activity;Physiological;Physiology;Placebo Control;Placebos;Plasma;Production;Property;Proteins;Protocols documentation;Quality of life;Quinones;Randomized;Reactive Oxygen Species;Recycling;Regimen;response;Rest;RNA;Succinate dehydrogenase (ubiquinone);Superoxide Dismutase;Superoxides;System;Testing;Therapeutic;Time;Unsaturated Fats;uptake;Vasomotor;Visit;Walking;walking performance;Woman;Work

PROJECT_TITLE: MitoQ treatment of claudication: myofiber and micro-vessel pathology


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: NUTRITION

PHR: PUBLIC HEALTH RELEVANCE While it is clear that early childhood development is a critical time period for development of later health and human capital, there are gaps in understanding the mechanisms underlying human capital development during the childhood years when intervention can make an enormous difference. China's major social, policy, and demographic shifts provide a unique opportunity examine how modifiable factors can be used to reduce adverse effects of such challenges in any context. The objective of the proposed study is to collect an 11th round of CHNS data and identify life-stage-specific exposures that predict health and human capital.

PI_NAMEs: ADAIR, LINDA S;POPKIN, BARRY M (contact)

PROGRAM_OFFICER_NAME: WALKER, JENELLE ROSE

PROJECT_TERMS: Address;Adolescent;Adult;Adverse effects;Adverse event;Affect;Age;age related;aged;Behavior;Behavioral;Biological;Biological Markers;Blood;Blood Pressure;Buffers;Caring;Case Study;Child;Child Development;Childhood;China;Chinese;Cognitive;cognitive development;cognitive function;Collection;Communication;Communities;Complex;Data;Data Collection;data dissemination;Data Element;Data Files;data repository;Demographic Transitions;Development;Diet;Dietary intake;Dietary Practices;Dimensions;early childhood;Early identification;Economics;Education;Educational Status;Elements;Environment;environmental change;Environmental Risk Factor;Event;Family;Fasting;follow-up;Fostering;Funding;Generations;genome wide association study;global health;Goals;grandparent;Health;Health care facility;Health Surveys;Health trends;Height;Household;human capital;Humidity;Income;Individual;Infrastructure;Intake;interest;intergenerational;Intergenerational transfer;Intervention;Investments;Laboratories;Left;Life;Life Style;Link;Location;Measures;media use;Mediating;member;migration;Modeling;Modernization;Monitor;nutrition;Nutrition Surveys;Occupations;One Child Policy;Outcome;Parents;Participant;Pattern;Personal Satisfaction;Physical activity;Physical Function;Policies;Population;Potassium;preservation;Puberty;public health relevance;Recording of previous events;Research;Research Institute;resilience;Resources;Respondent;Risk;Rural;Schools;Shapes;Siblings;skills;Sleep;social;Social Change;social factors;sociodemographics;Sodium;stool sample;Structure of nail of toe;Supermarket;Surveys;systematic review;Testing;Time;time use;transmission process;Transportation;United States National Institutes of Health;Variant;waist circumference;web site;Work;Youth

PROJECT_TITLE: Monitoring Social Change: Health and Human Capital from Childhood to Adulthood

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]