NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Health Relevance The proposed research will study the role of m6A RNA modifications in the regulation of gastrointestinal epithelial anti-Cryptosporidium response. The outcome will establish a foundation on which to build new, long- term mechanistic studies to define how intestinal epithelial cells orchestrate gastrointestinal mucosal immunity to Cryptosporidium infection, providing a basis for future development of novel therapeutic strategies targeting these mechanisms.

PI_NAMEs: CHEN, XIAN-MING  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS-Related Opportunistic Infections;antimicrobial;Antiparasitic Agents;Antisense Oligonucleotides;attenuation;Biochemical;Biology;Cells;Cessation of life;Child;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Development;Diarrhea;Double-Stranded RNA;Epithelial Cells;Epithelium;experience;Family;Foundations;Future;gastrointestinal;gastrointestinal epithelium;Gene Expression;Genes;genome-wide;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Highly Active Antiretroviral Therapy;HIV diagnosis;Host Defense;Human;Immune;Immune response;Immunity;immunopathology;In Vitro;in vivo;Infection;Infectious Agent;insight;Interferon Type II;Interferons;intestinal epithelium;Intestinal Mucosa;Intestines;Investigation;knock-down;Mediating;Messenger RNA;Methylation;methylome;Methyltransferase;microbial;Modeling;Modification;Molecular;Molecular Immunology;Morphology;Mucosal Immunity;Mucous Membrane;multiple myeloma M Protein;Mus;novel;novel therapeutic intervention;obligate intracellular parasite;opportunistic pathogen;Outcome;Parasites;pathogen;Pathogenesis;Patients;Persons;Post-Transcriptional RNA Processing;prevent;Regulation;Regulator Genes;Regulatory Element;Research;response;RNA;RNA Binding;RNA methylation;Role;Small Interfering RNA;Surface;Testing;Therapeutic;Transcript;Translations;Virus

PROJECT_TITLE: m6A methylation of IRGM transcripts in epithelial-Cryptosporidium interactions

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Glia dysfunction caused by environmental factors or genetic mutations is implicated in the cause and exacerbation of neurodegenerative disorders. We currently lack effective methods to target glial cells for therapy, and although viral vectors are used routinely in preclinical CNS models, there are limitations with these technologies that prevent clinical translation. We will develop dendrimer-based nanoparticles that permit multivalent presentation of ligands for cell surface transporters that we have identified to be uniquely and highly expressed on different glial cells and evaluate glial cell delivery of mRNA using these nanoparticles in the mouse brain under healthy and neuroinflammatory states.

PI_NAMEs: O'SHEA, TIMOTHY MARK (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Astrocytes;Binding;Biological Assay;Biological Models;Biology;Body System;Brain;Brain region;Cell Communication;Cell Line;Cell model;Cell surface;Cell Therapy;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Clinical;clinical translation;cohort;Collection;Corpus striatum structure;cytotoxicity;Dendrimers;design;Detection;Disease;disease model;DNA Sequence Alteration;Drug Delivery Systems;Effectiveness;efficacy evaluation;Enterobacteria phage P1 Cre recombinase;Environmental Risk Factor;Esterification;Evaluation;Foreign Bodies;Formulation;Foundations;Fructose;Functional disorder;Future;Generations;Genetic Transcription;Goals;Hippocampus;Homeostasis;Hour;Immune;immune activation;Immunohistochemistry;improved;in silico;In Vitro;in vivo;Inflammation;Injection of therapeutic agent;Injections;innovation;insight;Intervention;intraperitoneal;Ligands;Localized Disease;Messenger RNA;Methods;Microglia;Molecular;mRNA delivery;Mus;nanoparticle;nanotherapeutic;Nerve Degeneration;Nervous System Disorder;neural;neural circuit;Neuroanatomy;Neurodegenerative Disorders;neurodevelopment;Neuroglia;Neuroimmune;neuroinflammation;Neurons;Neuropharmacology;neurosurgery;Outcome;Parkinson Disease;Population;pre-clinical;prevent;Production;Proteins;Publishing;Reaction;Reporter;Reporter Genes;response;Route;scaffold;screening;Series;small molecule;Specificity;sulforhodamine 101;Surface;Symptoms;System;targeted treatment;Technology;tertiary amine;Testing;therapeutic nanoparticles;therapeutic target;therapy development;Tissues;trafficking;transcriptome;transcriptomics;transduction efficiency;Transgenic Mice;Transgenic Organisms;uptake;Viral Vector;Work

PROJECT_TITLE: Nanotherapeutics for Targeted Glial Cell Drug Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebral Palsy;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Rehabilitation;Rehabilitation

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative Forty percent of children with Cerebral Palsy have hemiplegia, characterized by impaired movement skills and muscle strength on one side of their body, leading to significant limitations in daily function and participation. This project proposes an innovative, child- and family-friendly, community-based training program using modified, commercially-available, joystick-operated ride-on-toys to promote self-initiated use and movement skills in the affected upper extremity in young children with hemiplegia between 3 and 8 years. Study findings have implications for the adoption of age-appropriate, highly enjoyable, and easy-to-operate modified toys by families as an adjunct to conventional therapy to increase children's functional use of their affected arm through goal-directed navigation through naturalistic environments.

PI_NAMEs: SRINIVASAN, SUDHA M (contact)

PROGRAM_OFFICER_NAME: AJISAFE, TOYIN DELE

PROJECT_TERMS: 8 year old;Accelerometer;Address;Adherence;Adoption;Advocate;Affect;Age;arm;Biomedical Engineering;bone;career;Caregivers;Caring;Cerebral Palsy;Child;Childhood;Clinic;Clinical;Clinical Practice Guideline;clinically significant;Communities;community setting;comparison control;Complex;Control Groups;conventional therapy;daily functioning;Data;design;Development;Diagnosis;Dose;Environment;evidence base;evidence based guidelines;experimental group;Family;feasibility testing;Feedback;feeding;follow-up;Foundations;Friends;functional improvement;Future;Gender;Goals;Grant;Guidelines;Hand;Hand Strength;Health Services Accessibility;Healthcare;Hemiplegia;Home;Hour;Impairment;implementation fidelity;improved;Incentives;Influentials;innovation;interdisciplinary collaboration;interest;Intervention;Joints;Joystick;kinematics;Life;Lower Extremity;Manuals;Measures;Medical Care Costs;Modeling;Motivation;Motor;motor impairment;Movement;Muscle;muscle strength;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;neural;Neuronal Plasticity;Neurosciences;novel;Occupational Therapy;Outcome;Outcome Measure;Parents;Pediatric Neurology;peer;Physical therapy;Physiological;Pilot Projects;Play;primary outcome;Problem Solving;programs;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;Recovery of Function;Rehabilitation therapy;Research Personnel;Rewards;satisfaction;Schools;Self Care;service gap;Side;skills;skills training;Standardization;Technology;Testing;Therapeutic;Time;tool;Toy;Training;Training Programs;treatment as usual;United States;Upper Extremity;Work;Wrist

PROJECT_TITLE: A novel, child-friendly, home-based navigation training program using joystick-operated ride-on-toys to improve upper extremity function in children with hemiplegia: A pilot study

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE We propose the Ecosystem for Multi-modal Brain-behavior Experimentation and Research (EMBER), an accessible and versatile data archive for storage, processing, and curation of multimodal neurophysiological and behavioral datasets. EMBER extends established BRAIN Initiative data infrastructure, provides new data harmonization and synchronization capabilities, and supports scalable integrations for data coordination and AI driven batch processing to enable the goals of the Brain Behavior Quantification and Synchronization (BBQS) program. This resource, developed in close collaboration with BBQS consortia, will facilitate dataset sharing, cross-modality querying, and data mining to fundamentally transform our understanding of cognition and behavior and provide a foundation for improved health and clinical outcomes.

PI_NAMEs: WESTER, BROCK A. (contact)

PROGRAM_OFFICER_NAME: JANES, DANIEL ERIC

PROJECT_TERMS: Adherence;Algorithms;Architecture;archive data;archived data;Archives;Artificial Intelligence;artificial intelligence algorithm;base;Behavior;Behavioral;Brain;brain behavior;Brain imaging;BRAIN initiative;Clinical;cloud based;Code;Cognition;Collaborations;Communities;Complex;Computer software;cost efficient;Data;data access;Data Aggregation;Data Analyses;data archive;Data Commons;data curation;Data Discovery;data harmonization;data infrastructure;data ingestion;data integration;data management;data mining;data modalities;data resource;Data Set;data standards;data structure;design;Development;distributed archives;Ecosystem;Ensure;Environment;experience;experimental study;Foundations;Goals;Health;Health protection;Heart;Human;Hybrids;improved;Individual;Informatics;Infrastructure;Ingestion;innovation;Institution;interoperability;Knowledge;laboratory experiment;Life Cycle Stages;Link;Machine Learning;Maintenance;Metadata;Modality;Modernization;multimodal data;multimodality;neural;neurobehavioral;neurophysiology;Neurosciences;Neurosciences Research;Organism;Outcome;Personally Identifiable Information;Policies;programs;Property;Publishing;repository;Reproducibility;Research;Research Personnel;Resource Informatics;Resources;Scheme;secondary analysis;Security;sensor technology;Shapes;Standardization;success;Technical Expertise;Technology;Testing;Time;tool;tool development;Training;Transcend;user-friendly;wearable device;web portal

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (02)]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Alveolar macrophages are the first host cells to be infected when Mtb is inhaled, and until recently they have been regarded as a homogeneous, anti-inflammatory population that is permissive for Mtb infection. However, our recent work revealed subpopulations of AMs that are capable of pro-inflammatory responses and able to contain Mtb growth. In the proposed project, we will study the molecular mechanisms that cause CD38- AMs to be non-responsive to Mtb infection, which will advance our fundamental knowledge of the underlying AM biology and enable us to identify potential therapeutic targets for immune-mediated control of Mtb growth.

PI_NAMEs: PISU, DAVIDE  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immunity;Alveolar Macrophages;Alveolus;Anti-Inflammatory Agents;ATAC-seq;Automobile Driving;Bacille Calmette-Guerin vaccination;Bacillus Calmette-Guerin Therapy;Bacteria;BCG Live;Biology;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Containment;cytokine;Data;Data Set;Disease Progression;Environment;Epigenetic Process;Exhibits;experimental study;fighting;fitness;Flow Cytometry;Genes;Genetic;Genetic Transcription;Goals;Growth;High Prevalence;Housing;Immune;Immune response;Immune Targeting;Immunity;improved;In Vitro;Infection;Infection Control;Infectious Agent;Inflammatory;Inflammatory Response;Inhalation;Innate Immune System;interstitial;Intranasal Administration;Knowledge;Link;Lung;Lymphocyte Subset;Macrophage;Mediating;Memory;Messenger RNA;Modification;Molecular;multimodality;multiple omics;Mus;Mycobacterium tuberculosis;Outcome;Pathway interactions;permissiveness;Phenotype;Physiological;Population;prevent;Process;Proliferating;recruit;Regulator Genes;Regulatory Pathway;Reporter;Research;response;Role;Shapes;single-cell RNA sequencing;Small Interfering RNA;Stress;T-Lymphocyte Subsets;Techniques;therapeutic target;Training;transcription factor;transcriptome sequencing;Tuberculosis;tuberculosis immunity;Vaccination;Validation;Work;XCL1 gene

PROJECT_TITLE: Elucidation of the molecular mechanism(s) for the non-responsiveness of CD38- AMs to tuberculosis infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: Project Imaging us splitter plan imaging Narrative: plays a central role in advancing biomedical sciences and developing new tools enable to address pressing biological questions. In this application, we propose to develop an optical  which will facilitate i maging fluorescence polarization of two colors simultaneously. We to ombine this splitter with lightsheet microscopy which is the method of choice for 3D live and develop a tailored image analysis pipeline for quantitative analysis. c

PI_NAMEs: PARENT, MATTHEW T (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Address;analysis pipeline;Anisotropy;Area;Biological;Biosensor;Cells;chromophore;Color;Complex;computerized data processing;cost effective;Data;data acquisition;Data Analyses;data analysis pipeline;design;detector;Development;Embryo;Energy Transfer;Environment;experience;flexibility;Fluorescence;Fluorescence Anisotropy;fluorescence imaging;fluorescence microscope;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;fluorophore;Goals;graphical user interface;Home;Homo;Image;Image Analysis;image registration;imaging approach;imaging detector;imaging modality;imaging system;innovation;lens;Light;Lighting;live cell imaging;Maps;Measures;Methods;Microscope;Microscopy;Modality;Molecular Conformation;Nanostructures;novel;optical polarization;Optics;Play;protein aggregation;protein oligomer;protein protein interaction;Protein-Protein Interaction Map;Proteins;quantitative imaging;Research;Resolution;Role;Sampling;Science;Scientist;Speed;System;Systems Analysis;Techniques;tool;tool development;transmission process;ultra high resolution;user-friendly;Work

PROJECT_TITLE: Building a lightsheet system with dual-color fluorescence anisotropy capability for mapping protein-protein interactions in live cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Fungal disease kills more than 1.5 million people annually. There is a dire need for new therapeutic interventions to treat these challenging infections. The proposed research effort will develop and evaluate inhibitors of newly discovered, Cu-only superoxide dismutase (SOD) enzymes found exclusively in fungi that could serve as a novel target for therapeutic intervention.

PI_NAMEs: COHEN, SETH M (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Active Sites;Address;Animal Model;anti-fungal agents;Binding;Biochemical;Bioinorganic Chemistry;Candida albicans;Candida auris;Cells;Cellular biology;Centers for Disease Control and Prevention (U.S.);Classification;Cuprozinc Superoxide Dismutase;Data;Death Rate;Development;Disease;Disseminated candidiasis;drug discovery;Drug resistance;efficacy testing;Enzymes;Excision;experience;extracellular;Female;fitness;fungus;Goals;Health;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infection;inhibitor;innovation;Intraperitoneal Injections;Invaded;Ions;Laboratories;Lead;lead candidate;Length;Libraries;Life;Macrophage;male;Mammals;Medicine;metalloenzyme;Metals;Microbe;Microbial Genetics;Modeling;Monitor;mouse model;Mus;Mycoses;new therapeutic target;novel;novel therapeutic intervention;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Persons;Phagocytes;pharmacophore;programs;Reactive Oxygen Species;Research;Resistance;Respiratory Burst;Role;Route;Safety;small molecule;small molecule inhibitor;Superbug;Superoxide Dismutase;Superoxides;Talents;Testing;Therapeutic;Therapeutic Intervention;Validation;Virulence

PROJECT_TITLE: Inhibitors of Cu-only Superoxide Dismutases as Novel Antifungals

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Emergency Care;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: JUXTOPIA, LLC

PHR: PROJECT NARRATIVE  The objective of the proposed NIH SBIR Phase I research and development (R&D) effort is to apply preliminary research results from the Juxtopia® and Maryland Fire & Rescue Institute (MFRI) study to develop and conduct a technical feasibility of the AI enabled Juxtopia® Intelligent HAZWOPWER Instructor (JiHi) and JiBand armlet to improve psychomotor (i.e., hands on) skill learning and evaluation during HAZWOPER training of Fire-Fighter/EMTs (both indoor and outdoor training environments).

PI_NAMEs: DOSWELL, JAYFUS TUCKER (contact)

PROGRAM_OFFICER_NAME: AHLMARK, KATHY

PROJECT_TERMS: Acute;Address;Adult;animation;Artificial Intelligence;Attention;Auditory;Augmented Reality;augmented reality headset;Bandage;Caring;chemical spill;Clinical;clinical practice;Clinical Skills;Collaborations;commercialization;Competence;Computer software;Control Groups;cost;Dangerousness;Data;deep learning algorithm;Electromyographs;Emergency Care;Emergency Medical Technicians;Emergency response;Emergency Situation;Engineering;Environment;Evaluation;experimental group;Exposure to;Fire - disasters;fire fighter;first responder;Focus Groups;Hand;hazardous materials disaster;Hazardous Substances;Hazardous Waste Operations and Emergency Response;head mounted display;improved;Institutional Review Boards;Instruction;instructor;knowledge base;Learning;Learning Skill;Manikins;Maryland;Measurable;Measurement;Medical emergency;mixed reality;multimodality;National Institute of Environmental Health Sciences;Occupations;Paramedical Personnel;Patients;Pattern;Performance;Persons;Phase;pressure;Price;prototype;Reporting;Research;research and development;response;skills;Small Business Innovation Research Grant;Students;Teacher Professional Development;Teaching Method;Technology;Testing;Text;Time;Tourniquets;Training;Traumatic injury;tutoring;United States;United States National Institutes of Health;Update;virtual;Virtual and Augmented reality;virtual reality;Visual;wearable device;Work

PROJECT_TITLE: JiHi, An Artificial Intelligent HAZWOPER e-trainer for tutoring and evaluating emergency first response clinical skill proficiency.

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-K (R4)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Pediatric

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative Workforce diversification is essential to meet growing US demands in aging research, biomedical science and broader STEM fields. Older Americans are one of the fastest growing demographics in the country, yet geriatric educational training programs are lacking, particularly among younger students. The UMB RAMP program will fill this gap by providing West Baltimore high school students with foundational knowledge required to understand and translate concepts related to aging research while providing the skills to perform basic lab techniques and clinical skills that will be applied in a lab or research-based experience with UMB faculty conducting aging-focused research as a strategy to expose young students to the aging field.

PI_NAMEs: DENNIS, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acclimatization;Address;Age;Aging;American;Applied Research;Applied Skills;Baltimore;Basic Science;bench to bedside;Biomedical Research;Capsicum;career;Career Choice;Cities;Clinical;Clinical Research;Clinical Skills;cohort;college;Communication;Communities;Community Health Education;Community Outreach;Country;demographics;economic need;Education;Educational Curriculum;Educational Status;efficacy evaluation;Elderly;Environment;experience;Exposure to;Face;Faculty;faculty mentor;Gerontology;Goals;graduate student;Health;health disparity;health equity;Healthcare;high school;High School Student;improved;Individual;Institution;interest;Internships;Knowledge;Learning Skill;Maryland;Measurement;Mentors;Minority;Next Generation Science Standards;Outcome;Pathway interactions;peer;Perception;Pilot Projects;Population;programs;Questionnaires;Ramp;Reduce health disparities;Research;Resources;Rotation;Scholars Program;Schools;Science;Science, Technology, Engineering and Mathematics Education;Self Efficacy;skill acquisition;skills;STEM career;STEM field;student mentoring;student training;Students;summer program;summer research;Techniques;Time;Training;Training and Education;Training Programs;Translating;Translational Research;Universities;Work;Youth

PROJECT_TITLE: UMB RAMP: UMB Research And Mentoring Program to develop skills and promote interest in STEM fields through hands-on exposure to academic research among West Baltimore Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Mutation in GATAD1, a histone 3 trimethylated at lysine 4 (H3K4me3) interactor, is associated with dilated cardiomyopathy (DCM) and heart failure, highlighting its importance for cardiac function. However, little is known as to the specific role of GATAD1 in cardiomyocytes, or molecular mechanisms by which GATAD1 loss- of-function results in cardiomyopathy. Proposed studies are aimed at understanding the function of GATAD1 in cardiomyocytes at the molecular, cellular, and physiological levels during aging and in pressure-overload induced heart failure.

PI_NAMEs: FANG, XI  (contact)

PROGRAM_OFFICER_NAME: SHARMA, KARLIE ROXANNE

PROJECT_TERMS: Address;Adult;Age Months;Age Years;Aging;alcohol exposure;Amino Acid Substitution;aorta constriction;autosome;Binding;Biochemical;Biological Process;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cholesterol;Chromatin;cofactor;Complex;congenital heart abnormality;Development;Dilated Cardiomyopathy;Elderly;Embryo;Event;exome sequencing;Family;fetal;Gene Expression;Generations;Genes;Genetic Transcription;genome-wide;Goals;Heart;Heart failure;heart function;Heterozygote;Histologic;Histones;Human;Individual;insight;Knock-out;Knockout Mice;Knowledge;loss of function;loss of function mutation;LoxP-flanked allele;Lysine;Maintenance;Maps;Methylation;Modeling;Molecular;Molecular Analysis;mouse model;Mus;Mutation;mutation carrier;myosin light chain 2;new therapeutic target;Operative Surgical Procedures;Pathway interactions;Patients;Penetrance;Phenotype;Physiological;Physiology;Pilot Projects;Play;pressure;programs;Proline;promoter;Proteins;Rare Diseases;Reporting;response;Role;Serine;Stress;Structure;Symptoms;Tertiary Protein Structure;Tissues;transcription factor;Transcriptional Regulation;transcriptome;Transgenic Mice;Xenopus laevis;Zebrafish;Zinc Fingers

PROJECT_TITLE: The role of GATAD1 in cardiomyocyte and cardiomyopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-1 (01)]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: DAYTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative A major obstacle in understanding the role of potential mediators of placental development and analysis of placental dysfunction has been the lack of a facile method for trophoblast gene manipulation in intact animals. We propose to validate a novel in utero trophoblast transgenesis approach, in which lentiviral infection of blastocysts in utero provides a rapid, trophoblast-specific, and highly efficient way to evaluate critical mediators of placental development and pregnancy-associated disorders.

PI_NAMEs: BROWN, THOMAS L (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Acceleration;Affect;Anesthetics;Animals;Binding;blastocyst;Blood Pressure;Cell Culture Techniques;Chemicals;Complex;Copulation;Data;Detection;Development;Disease;Dose;Doxycycline;Embryo Transfer;Epithelial Cells;Epithelium;Excision;experimental study;Family;Family member;Female;fetal;Fetal Development;Fetus;Functional disorder;Gene Expression;Gene Transfer;Gene Transfer Techniques;Genes;genetic manipulation;Green Fluorescent Proteins;Growth;Hormones;Horns;Hour;Immunofluorescence Immunologic;Immunohistochemistry;implantation;in utero;In Vitro;Incubated;Infection;knock-down;Lentivirus;Ligand Binding;Litter Size;Low Density Lipoprotein Receptor;Measures;Mediating;Mediator;member;Methods;Morphology;Mus;natural Blastocyst Implantation;novel;novel strategies;offspring;Operative Surgical Procedures;Organ;overexpression;Partner in relationship;Placenta;Placentation;Postpartum Period;Pregnancy;Pregnancy Rate;pregnant;prevent;Process;pup;receptor;Reporting;Role;sex;small hairpin RNA;Specificity;success;Superovulation;Techniques;Testing;Tetanus Helper Peptide;Tetracyclines;Tissues;tool;trophoblast;Uterus;Vesicular stomatitis Indiana virus;Viral;Viral Envelope Proteins;Weight;Zona Pellucida

PROJECT_TITLE: In Utero Trophoblast Transgenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-C (02)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: OMAHA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: PROJECT NARRATIVE Blockages in the leg arteries are often treated with flexible but non-stretchable synthetic arterial substitutes called bypass grafts. These grafts tend to buckle and kink during limb flexion, promoting new blockages that require repeat interventions. We propose to develop a stretchy synthetic bypass graft that resists buckling similarly to healthy leg arteries and assess its performance during limb flexion using benchtop, human cadaver, computational, and large animal models.

PI_NAMEs: MALECKIS, KASPARS  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acute;Address;analog;Anastomosis - action;Animal Model;Anisotropy;Arteries;Atherosclerosis;Behavior;Bilateral;biomaterial compatibility;Biomechanics;Biomimetics;Blood Vessels;Bypass;Cadaver;Characteristics;Chronic;Clinic;Clinical;Clinical Research;commercialization;cost;critical limb Ischemia;design;Development;Devices;Direct Costs;Disease;Domestic Pig;efficacy evaluation;elastomeric;Elastomers;Electron Microscopy;Evaluation;Failure;Family suidae;Feasibility Studies;Fiber;flexibility;Functional Regeneration;Future;Histologic;Human;implantation;improved;In Vitro;in vivo;in vivo regeneration;Industry;Injury;innovation;Intellectual Property;internal control;Intervention;Knowledge;Leg;limb amputation;Limb structure;Lower Extremity;manufacture;manufacturing process;Measurable;Mechanics;Methods;microscopic imaging;Modeling;Morbidity - disease rate;mortality;multidisciplinary;nanofibrillar;Nanomanufacturing;National Heart, Lung, and Blood Institute;Nature;new technology;novel;Operative Surgical Procedures;Outcome;Performance;Peripheral arterial disease;Persons;Phase;Physiological;preclinical study;pressure;prevent;prototype;Public Health;Quality of life;reconstruction;Recurrence;repaired;Research;Resources;Safety;Secure;Standardization;Stretching;Techniques;Technology;Testing;Tissues;tool;vascular bed;Vascular Graft;Work

PROJECT_TITLE: Axially Prestretched Elastomeric Graft (APENG) for Lower Extremity Arterial Reconstructions

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (J2)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Fibrous dysplasia causes fibrotic bone lesions, full of immature bone forming osteoblasts, that result in pain, deformity and fracture susceptibility. Antibody that blocks the cytokine RANKL inhibits formation of bone eroding osteoclast cells and also improves bone lesions in fibrous dysplasia, but has side effects that limit use and thus alternative therapies are needed. These experiments proposed will help to reveal the mechanism by which anti- RANKL antibodies inhibit bone lesions with the goal of identifying alternative therapeutic targets.

PI_NAMEs: CHARLES, JULIA F (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Actins;Affect;Alternative Therapies;Animal Model;Antibodies;Antibody Therapy;Automobile Driving;Binding;Biological Process;Biology;bisphosphonate;Blocking Antibodies;bone;bone erosion;Bone Formation Inhibition;Bone remodeling;Bone Resorption;bone turnover;Breast Epithelial Cells;Cell Lineage;cell type;Cells;comparative efficacy;Coupling;CSF1 gene;CSF1R gene;cytokine;Cytokine Receptors;Data;Deformity;Development;digital;effective therapy;Environment;experience;experimental study;Fibrosis;Fibrous Dysplasia;Fracture;Genetic Transcription;Goals;Growth;Hematopoietic;Human;Immature Bone;improved;Individual;inhibiting antibody;Inhibition of Cell Proliferation;insulin sensitivity;Intestines;Investigation;Ischemic Stroke;Lesion;Ligands;lymph nodes;M cell;Marrow;Modeling;Molecular;mosaic;mouse model;Mus;mutant;Mutation;neuroprotection;neutralizing antibody;NF-kappa B;Osteitis Fibrosa Disseminata;osteoblast differentiation;Osteoblasts;Osteocalcin;osteoclastogenesis;Osteoclasts;Pain;Pathogenesis;Pathologic;Pathway interactions;Patients;phase 2 study;Phenotype;Physiologic Thermoregulation;Positioning Attribute;postnatal;pre-clinical;Predisposition;prevent;Proliferating;receptor;Receptor Inhibition;response;Role;sarcopenia;side effect;Signal Transduction;skeletal;skeletal stem cell;Smooth Muscle;Specialized Epithelial Cell;targeted treatment;Testing;therapeutic target;Thymic epithelial cell;Tissues;transcriptomics;treatment comparison;Withdrawal

PROJECT_TITLE: Osteoclasts or RANKL: Which is the critical target in treatment of fibrous dysplasia bone lesions?

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project studies neural activities underlying social extinction of avoidance, a phenomenon that the behavior of avoiding an aversive object or place can be reduced by another social subject. Its outcomes will advance our understanding of neural circuit mechanisms in social extinction and potentially inspire novel strategies for better social support and intervention in anxiety disorders including post-traumatic stress disorder and special phobia.

PI_NAMEs: JI, DAOYUN  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Address;Animals;Anterior;Anxiety Disorders;Area;avoidance behavior;Back;Behavior;Behavioral;behavioral study;Brain;cell cortex;Cells;cingulate cortex;Code;Companions;conditioned fear;density;design;Detection;Distal;Electric Stimulation;Environment;Event;experience;Extinction;fear memory;foot;Freezing;Fright;Hippocampus;in vivo;Knowledge;Learning;Link;Location;Modeling;neural;neural circuit;Neurons;novel;novel strategies;optogenetics;Outcome;Outcome Study;Patients;Pattern;Phobias;Post-Traumatic Stress Disorders;Rattus;Rodent;Role;Shock;social;social group;social interventions;social learning;Social support;Specific Phobia;Specific qualifier value;Stimulus;Symptoms;Testing;Time

PROJECT_TITLE: Neural circuit mechanisms in social extinction of conditioned place avoidance

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Data Science;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Project Narrative: AR Tech-DaSH is a technology and data science in health and medicine focused outreach exposure program for high school students, teachers and the community primarily in the northwest part of the state of Arkansas. The program incorporates imaging technologies and a data science curriculum focused on health and medicine in classroom outreach, a ten day summer camp, community outreach events hosted by the high school camp participants serving as STEM Ambassadors, and a virtual STEM and data science focused outreach to students and teachers across the state. The successful implementation of the Arkansas Tech-DaSH program will serve as a model for attracting students towards STEM and data science careers to ensure that the future STEM workforce better reflects the diverse population of the US.

PI_NAMEs: PHELAN, KEVIN D (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Affect;Anatomy;Arkansas;Attitude;Belief;Cardiovascular system;career;case-based;cohort;Communities;Community Health Education;Community Outreach;community partners;Country;Coupling;Data;Data Analyses;data mining;Data Science;Data Set;design;Diabetes Mellitus;Disease;Educational Curriculum;Educational Status;Educational workshop;Ensure;Event;experience;Exposure to;Face;Faculty;Familiarity;Future;Goals;Hand functions;Health;health literacy;high school;high school program;High School Student;Hispanic;Image;imaging science;Imaging technology;Immunology;Income;Industry;interest;Intervention;Knowledge;Leadership;Learning;Learning Skill;Life;Life Style;Machine Learning;Malignant Neoplasms;mathematical sciences;mathematics content;Medical;Medical Imaging;Medical Students;Medical Technology;Medicine;minority student;Modeling;ninth grade;novel strategies;Obesity;outreach;Parents;Participant;Patient Simulation;Patients;peer coaching;Population;Population Heterogeneity;programs;Research;role model;Rural;school district;Schools;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;skills;Societies;Socioeconomic Status;Standardization;STEM career;Stethoscopes;Structure;Students;teacher;Teacher Professional Development;Technology;ultrasound;undergraduate student;Underrepresented Populations;Underserved Population;Universities;virtual;virtual assessment;virtual classroom;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: AR Tech-DaSH: Arkansas Technology and Data Science in Health and Medicine


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The long-term goal of our research is to develop safe and effective therapies specifically for neonatal hypoxic-ischemic encephalopathy (HIE). This would have an enormous impact on the burden that our society bears to rehabilitate and care for severely brain-damaged children. This project focuses on studying how cholesterol metabolism in microglia, the immune cells in the brain, affects their phenotype and behaviors, as well as the inflammatory responses following brain hypoxia ischemia.

PI_NAMEs: JIANG, XIANGNING  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 25-hydroxycholesterol;Acute;Address;Affect;Affinity Chromatography;Aging;Antibodies;Area;attenuation;Behavior;Behavior Disorders;Blood Vessels;Brain;Brain Hypoxia-Ischemia;Brain Injuries;brain repair;Caring;cell type;Cells;Child;Cholesterol;cholesterol 24-hydroxylase;Cholesterol Homeostasis;clinically relevant;Complex;cytokine;Demyelinating Diseases;Dendrites;Diagnostic;differential expression;effective therapy;Enzymes;Functional disorder;Functional impairment;Gene Expression Profile;Genes;Genetic Recombination;Genetic Transcription;Goals;Homeostasis;Human;Hydroxycholesterols;Hydroxylation;Hypoxic-Ischemic Brain Injury;Immune;Immune response;Immunity;Immunoprecipitation;immunoregulation;Impaired cognition;improved;Infant;Infiltration;Inflammation;Inflammatory Response;injured;Innate Immune Response;Invaded;Ipsilateral;Knock-out;Knowledge;lipid metabolism;Lipids;Literature;loss of function;LoxP-flanked allele;Macrophage;Maintenance;Mediating;Membrane;Microglia;Mixed Function Oxygenases;Modeling;Molecular;monocyte;Morbidity - disease rate;mortality;motor impairment;mouse model;Mus;neonatal brain;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonatal mice;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurons;neuropsychiatric disorder;novel;novel therapeutics;Organ;Pathway interactions;Patients;Perinatal Brain Injury;Peripheral;Phagocytes;Phase;Phenotype;Pilot Projects;Play;Positioning Attribute;postnatal;Process;Production;promoter;Publishing;Reactive Oxygen Species;Recovery;Regulation;repaired;Research;Resolution;Ribosomes;RiboTag;RNA Binding;Role;single-cell RNA sequencing;Societies;Tamoxifen;Technology;Testing;therapeutic target;Tissues;transcriptome;transcriptome sequencing;Translating;translating ribosome affinity purification and RNA-sequencing;Viral Physiology

PROJECT_TITLE: A critical role for microglial cholesterol 25-hydroxylase in regulating neuroinflammation following neonatal brain hypoxia-ischemia

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE The Texas Research Experience eXperiment (TREX) project will establish partnerships for the development of high school curricular modules and career development activities designed to stimulate interest in and preparation for careers in science, technology, engineering, and medicine through longitudinal mentoring of teachers and students by university faculty and summer research internships for students in faculty laboratories. The project is focused on rural school districts that are in medically underserved communities and have high proportions of students who are of low socioeconomic status and underrepresented in science and medicine.

PI_NAMEs: CANNON, CAROLYN LOUISE (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Accreditation;Administrator;Attitude;Biomedical Engineering;Biomedical Research;career;career development;career preparation;Collaborations;college;Communities;comparative;Critical Thinking;curriculum development;Data;design;Development;Education;educational atmosphere;Educational Curriculum;Educational Models;effectiveness evaluation;eleventh grade;Engineering;Evaluation;experience;experimental study;Faculty;faculty mentor;faculty research;Feeling;Fostering;Foundations;Goals;health disparity;high school;High School Faculty;High School Student;innovation;Instruction;Instructional Technology;instrument;interest;Internships;Journals;Knowledge;Laboratories;Learning;Learning Module;Link;Literature;low socioeconomic status;medical schools;medically underserved;Medicine;member;Mentors;Mentorship;Methods;Modeling;multidisciplinary;Next Generation Science Standards;Outcome;outreach;Parents;Participant;pilot test;programs;Public Health;Quasi-experiment;Research;Resource Sharing;Rural;school district;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientific Inquiry;Self Efficacy;Series;skill acquisition;skills;South Texas;STEM career;student participation;Students;success;summer research;teacher;teacher mentor;Teacher Professional Development;Technical Expertise;Technology;Texas;theories;Training;underserved community;Universities;university student;Work

PROJECT_TITLE: TREX:Texas Research Experience Experiment


NIH_SPENDING_CATS: Autoimmune Disease;Lupus

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Free oligosaccharides represent an understudied set of bioactive molecules. We will use chemoproteomic mass spectrometry-based technologies to elucidate the interactome of Man(b1- 4)GlcNAc, a bioactive disaccharide implicated in autoimmunity. This interactome will lead to an enhanced understanding of the molecular mechanisms through which free oligosaccharides exert important biological activity.

PI_NAMEs: HUANG, MIA L (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Acylation;Affinity;Alkynes;amidation;Autoimmune;Autoimmune Diseases;Autoimmunity;Binding;Binding Proteins;Biological;Biological Process;Carboxylic Acids;Catalogs;Cells;Chemicals;chemoproteomics;Chronic;Confocal Microscopy;Data;Derivation procedure;diazine;Disaccharides;Disease;Ensure;Evaluation;experimental study;Flow Cytometry;Glycoconjugates;glycosylation;Goals;Human;immune activation;Immune response;improved;insight;knock-down;Lectin;Location;Lupus;Lupus Erythematosus;man;Mannose;Maps;Mass Spectrum Analysis;Membrane;Men's Role;Methods;Modeling;Molecular;Oligosaccharides;Outcome;Pathogenicity;Pathway interactions;Permeability;protein complex;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;receptor;response;Systemic Lupus Erythematosus;TBK1 gene;Technology;Ultraviolet Rays;Work

PROJECT_TITLE: Elucidation of the interactome for the bioactive disaccharide Man(B1-4)GlcNAc

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

PHR: PROJECT NARRATIVE  Population-based cervical screening including self-collect cervicovaginal samples (SCCS) has resulted in reducing the cervical cancer burden in high-income countries and SCCS can help minimize the cervical cancer burden among women living with HIV (WLWH) in Ghana. However, the implementation and dissemination mechanisms to translate SCCS into Ghana’s healthcare systems have not been developed. This proposal seeks to develop contextually appropriate adaptation and implementation toolkits to enhance the adoption of SCCS in healthcare practices in Ghana, increase CCS, and reduce the CC burden.

PI_NAMEs: ASARE, MATTHEW  (contact);OBIRI-YEBOAH, DORCAS

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Administrator;Adopted;Adoption;Affect;Area;arm;Beds;Behavior;Belief;Cancer Burden;cervical cancer prevention;Cervical Cancer Screening;cervicovaginal;Characteristics;Climate;Communication;Communities;Consolidated Framework for Implementation Research;contextual factors;Control Groups;cost;Country;Databases;Development;Diagnostic Reagent Kits;Dissemination and Implementation;Education;effectiveness testing;efficacy evaluation;Eligibility Determination;Enrollment;Epidemiology;Evaluation;evidence base;Focus Groups;Future;Ghana;Grant;group intervention;Health;Health Personnel;health training;Healthcare;Healthcare Systems;high risk;HIV;Home;Hospitals;Human Papillomavirus;Hybrids;implementation cost;implementation/effectiveness;improved;Income;Infrastructure;Intervention;intervention delivery;intervention participants;Interview;Knowledge;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Measures;member;Methods;Modality;Modeling;Nurses;Outcome;Pap smear;Participant;patient health information;Patient Recruitments;Patients;pilot test;Policies;population based;Positioning Attribute;premalignant;prevent;Prevention education;primary outcome;Procedures;Process;programs;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Resource-limited setting;Resources;Risk;Sampling;satisfaction;screening;Screening for cancer;screening guidelines;screening program;social;social stigma;Structure;Surveys;System;Teaching Hospitals;Techniques;Testing;Time;Translating;treatment arm;uptake;Woman

PROJECT_TITLE: Development of implementation toolkits to promote HPV self-sampling behavior among Women Living with HIV in Ghana

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE Stem cell-based therapies offer tremendous promise for curing a number of human diseases, however, there is a need to decrease cost and improve efficiency of stem cell differentiation. Our project addresses this need through the development of novel cell carriers that allow to decrease the use of expensive reagents and to cul- ture stem cells more scalably.

PI_NAMEs: REVZIN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Acute;Address;Adult;Affect;aqueous;Artificial Liver;Benchmarking;Bioreactors;blood glucose regulation;Cadaver;capsule;Cell Transplantation;cell type;Cells;Chronic;cost;Cues;Cytoprotection;Data;density;design;Development;differentiation protocol;disease transmission;Drug Metabolic Detoxication;Encapsulated;Endoderm;Engineering;Epigenetic Process;Family suidae;Fibroblast Growth Factor;Future;Goals;Growth Factor;Heparin;Hepatic;Hepatic Mass;Hepatocyte;Human;human disease;human embryonic stem cell;human pluripotent stem cell;Hydrogels;Immunofluorescence Immunologic;improved;Individual;induced pluripotent stem cell;interest;Kinetics;Liver;Liver diseases;Liver Failure;liver function;liver transplantation;Maintenance;Mechanics;Microcapsules drug delivery system;Molecular Biology;Monitor;Nodal;novel;Nutrient;Organ;Organ Transplantation;Oxygen;Patients;Persons;Phenotype;pluripotency;pluripotent stem cell differentiation;Protein Biosynthesis;Reagent;Recovery;Risk;RNA;sensor;Signal Transduction;Source;spheroids;stem cell differentiation;stem cell therapy;stem cells;Suspension Culture;System;technology development;Therapeutic;timeline;Tissues;Transplantation;Waiting Lists;Zoonoses

PROJECT_TITLE: Engineering microcapsules for scalable differentiation of human pluripotent stem cells into hepatocytes

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PUBLIC HEALTH RELEVANCE Human papillomaviruses are causative agents in a number of ano-genital and oral cancers; HPV causes 5% of all cancers. There are no therapeutics that target the virus to assist with the alleviation of this disease burden and the focus of this application is to enhance our understanding of the HPV16 life cycle and how it contributes to HPV16 oncogenesis. We have discovered novel host transcriptional regulation by the HPV16 E2 protein, and this proposal will investigate the mechanism of this regulation and the consequences for the viral life cycle and HPV16 positive cancers.

PI_NAMEs: MORGAN, IAIN  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Anogenital cancer;Attenuated;Binding;burden of illness;Cancer cell line;Cancer Etiology;Cancer Patient;Cell division;Cell Line;Cell Nucleus;Cells;chemotherapeutic agent;Chromatin;Cisplatin;Clinical;combat;Complex;CRISPR/Cas technology;Data;Daughter;Disease;Disease Outcome;DNA;DNA biosynthesis;DNA Methylation;DNA-Binding Proteins;epithelial to mesenchymal transition;experimental study;Future;Gene Expression;Gene Expression Profile;gene repression;Genes;Genetic Transcription;Genome;Head and Neck Cancer;helicase;high risk;Human;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Immune;Infection;keratinocyte;Life Cycle Stages;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Mediating;Modeling;Monitor;mutant;Natural Immunity;novel;novel strategies;novel therapeutic intervention;Outcome;overexpression;penis foreskin;plasmid DNA;Play;Process;promoter;Proteins;public health relevance;Reagent;recruit;Regulation;Replication Initiation;Replication Origin;Repression;response;Reverse Transcription;Role;segregation;Site;STAT3 gene;therapeutic target;Transcriptional Regulation;transcriptome sequencing;Transferase;treatment response;tumorigenesis;TWIST1 gene;vector control;Viral;Viral Genome;Viral Physiology;Viral Proteins;Virus;Virus Diseases;virus host interaction;Virus Replication;wound healing

PROJECT_TITLE: Mechanisms and consequences of human papillomavirus 16 E2 regulation of host gene transcription

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Microbial biofilm infections are a leading complication in healing of wounds arising in a multitude of settings, including severe burns, non-healing pressure ulcers, dog bites, surgical site infections, and gunshot wounds; the physical barrier of the biofilm makes it recalcitrant to traditional antibiotic treatment. A potential solution that shows activity against biofilms in vitro is the use of novel graft polyelectrolyte surfactants (PS) with the ability to encapsulate into nanoparticles and deliver cationic antimicrobial peptides (CAMs) across the biofilm barrier. In the proposed work, PS-CAM nanoparticles will be deployed in the wound infection environment, both for imaging and for treatment, by formulation into a “nanospray” that is able to achieve broad coverage within the wound bed, avoid rapid clearance of dyes or of active CAMs in the highly active regenerating wound environment, and penetrate biofilm barriers via the polyelectrolyte surfactant detergency.

PI_NAMEs: ROTH, CHARLES M. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: acrylic acid;Antibiotic Resistance;Antibiotic Therapy;antimicrobial;Antimicrobial Cationic Peptides;Bacteria;Bacterial Adhesion;Biological;Carbopol;Cellular Metabolic Process;Characteristics;Chemicals;Chronic;Clinical;clinical application;Complication;contrast imaging;Contrast Media;cytotoxic;decubitus ulcer;Detergents;Diffusion;Dog Bite;Dyes;Encapsulated;Environment;experimental study;extracellular;Eye;FDA approved;Formulation;Gene Expression;Gunshot wound;Image;Impaired wound healing;In Vitro;in vivo;Indocyanine Green;Infection;interest;Meta-Analysis;Microbial Biofilms;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Multi-Drug Resistance;Mus;nano;nanocomplexes;nanoformulation;nanoparticle;Natural regeneration;near infrared dye;non-healing wounds;novel;Oxides;Penetration;phantom model;Pharmaceutical Preparations;physical property;Poloxamers;Polymers;Prevalence;prevent;Process;prototype;resistance factors;self assembly;severe burns;Signal Transduction;Surface;surfactant;Surgical Wound Infection;Testing;Therapeutic;tissue phantom;Triton X100;Tweens;Work;wound;wound bed;wound environment;wound healing;Wound Infection

PROJECT_TITLE: Nanospray treatment of biofilm infections in wounds

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative More than 30% of pregnant women receive oxytocin for induction of labor in the United States. Despite concern over an association between this practice and the risk of autism spectrum disorders (ASD), a thorough mechanistic understanding is currently lacking. Considering the importance of oxytocinergic signaling in ASD, this proposal will comprehensively investigate the impact of maternally administered oxytocin on the oxytocinergic system in the developing brain using a hi-fidelity pregnant mouse model for labor induction.

PI_NAMEs: PALANISAMY, ARVIND  (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: 3-Dimensional;Address;Adverse effects;Affect;Age;Animal Model;Animals;Antibodies;Area;Attention;autism spectrum disorder;Behavior;behavior test;Behavioral;behavioral study;Birth;boys;Brain;Brain imaging;Brain Mapping;Brain region;brain tissue;Child;Child Health;Clinical Research;Collaborations;Data;density;Development;Discipline of obstetrics;Dose;early life exposure;Empathy;epidemiologic data;epidemiology study;Ethics;experimental study;Exposure to;Female;fetal;Fluorescence Microscopy;Gene Expression;Genes;Genetic;Genetic Polymorphism;human subject;Hypothalamic structure;Image;Imaging Techniques;Impairment;improved;In Situ Hybridization;Induced Labor;innovation;Intravenous;Investigation;Knock-in;Knowledge;Light;male;Maps;mass spectrometric imaging;medical schools;Medication Management;Microprocessor;microscopic imaging;Minor;model of autism spectrum disorder;Modeling;Modification;Mothers;mouse model;Mus;Neonatal;neonatal mice;neurobehavior;neurobehavioral;Neurodevelopmental Disorder;neurodevelopmental effect;Neurons;new technology;Newborn Infant;offspring;Outcome;Oxytocin;Oxytocin Receptor;Pathway interactions;Pennsylvania;Peptides;Perinatal;pharmacologic;postnatal;pregnant;Pregnant Women;Prevalence;prospective;public health relevance;Pump;Rattus;receptor expression;Receptor Gene;Receptor Signaling;Reporter;Reporter Genes;Research;Resolution;Risk;RNA;Scientific Inquiry;sex;Signal Transduction;social;Social Behavior;Social Functioning;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;System;Testing;tomography;Transgenic Organisms;two-photon;United States;Universities;Venus;Visualization;Washington;Woman;Work

PROJECT_TITLE: Mapping postnatal oxytocinergic system and offspring neurobehavior after induced birth with oxytocin

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The proposed experiments will determine the neural mechanisms responsible for enhanced balance training effectiveness that come from intermittent visual perturbations. The studies also determine how to improve balance to enhance performance outcomes in both young and older adults. The results will lead to new therapeutic interventions for older individuals and individuals with neurological or musculoskeletal deficits that have a high propensity for falls.

PI_NAMEs: FERRIS, DANIEL P (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Aerobic Exercise;Affect;Age Years;aging related;Area;Balance training;base;Behavioral;behavioral outcome;Brain imaging;Characteristics;clinical translation;Clinical Trials;Control Groups;Data;density;Educational Intervention;Effectiveness;efficacy evaluation;Elderly;Electroencephalography;Electromyography;Equilibrium;experience;experimental study;fall injury;Fall prevention;falls;Feedback;Future;Goals;Goggles;Health Care Costs;Health Status;Human;improved;improved outcome;Incidence;Individual;insight;Intervention;Laboratories;lens;Light;light transmission;limb loss;liquid crystal;Longevity;Motion;Multiple Sclerosis;multitask;Musculoskeletal;Neurologic;Neurologic Deficit;Neuromechanics;neuromechanism;novel therapeutic intervention;older adult;Older Population;Outcome;panacea;Parietal Lobe;Participant;patient population;Performance;pilot test;Population;post stroke;preventive intervention;Quality of life;Research;Research Support;Resolution;Rotation;Sensory;somatosensory;Spinal cord injury;strength training;stroke hemiparesis;success;Tai Ji;Testing;Time;Training;treadmill;vestibular system;virtual reality game;Visible Radiation;Vision;Visual;visual feedback;Walking;Yoga;young adult

PROJECT_TITLE: "Intermittent Visual Perturbations to Enhance Balance Training"

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The relationship between natural features of land such as bedrock lithology, water quality, and human health remains poorly understood. This project will not only identify the relationship between bedrock, water quality, and human health, but also identify how bedrock lithology and uneven patterns of human settlement impact health disparities through water quality.

PI_NAMEs: MUELLER, JOEL THOMAS (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Affect;Area;Automobile Driving;Back;Censuses;chemical property;Chemicals;Collaborations;Collection;contaminated water;Data;Data Collection;Data Set;Development;drinking;drinking water;Electrodes;Environment;Equation;Ethnic Origin;Filtration;Fostering;Funding;Future;Generations;geochemistry;Geography;Government;ground water;Health;health data;health disparity;health disparity populations;health equity;health inequalities;Household;Human;innovation;interdisciplinary approach;land use;Lead;Link;Malaise;Malignant Neoplasms;marginalized population;Mental Health;Methodology;Methods;migration;Modeling;mortality;Natural Resources;novel;Obesity;obesogenic;Oklahoma;Outcome;Pattern;Perception;Personal Satisfaction;physical property;physical science;pollutant;pollutant transport;Population;population health;Process;Property;Psyche structure;Public Health;public health research;Race;racism;Reaction;Research;Resources;Role;role model;Sampling;Science;secondary analysis;social;Social Sciences;Societies;sociodemographics;Soil;Source;spatiotemporal;Subgroup;Surface;Survey Methodology;Surveys;Techniques;Testing;Toxin;United States;United States National Institutes of Health;Water;water quality;water sampling;water testing;well water

PROJECT_TITLE: Understanding the role of bedrock, settlement patterns, and water quality in human health equity

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE A better understanding of the neural circuitry that control motivated behavior is critical to developing new strategies to treat and prevent drug addicition and other compulsive disorders. Dopamine neurons in the ventral tegmental area (VTA) have been widely implicated as a common substrate of drugs of abuse, but other VTA neuron types also contribute and may represent new targets for future intervention. This research program will evaluate the contribution of novel VTA populations to behavioral reinforcement and opioid-induced behaviors.

PI_NAMEs: HNASKO, THOMAS  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Address;Affect;Attention;Axon;Basal Ganglia;Behavior;Behavior assessment;behavior influence;Behavioral;behavioral response;Calcium;Cell Nucleus;cell type;Cells;CRISPR/Cas technology;Data;Dendrites;design;Development;Disease;Disinhibition;Dopamine;dopaminergic neuron;drug abuse prevention;Drug Addiction;drug of abuse;Drug Targeting;Electrophysiology (science);Fiber;frontal lobe;Future;gamma-Aminobutyric Acid;Genetic;Globus Pallidus;Glutamates;Goals;Habenula;Histology;in vivo;Interneurons;Intervention;Lateral;Learning;Ligands;Limbic System;Link;Maps;Measures;Mediating;Modeling;motivated behavior;mu opioid receptors;Mus;neural circuit;neuronal cell body;Neurons;neuropsychiatric disorder;neurotransmitter release;novel;Nucleus Accumbens;Opioid;opioid use disorder;optogenetics;Output;Photometry;Population;Population Heterogeneity;Positioning Attribute;postsynaptic;postsynaptic neurons;Presynaptic Terminals;Productivity;programs;Psychological reinforcement;receptor expression;Receptor Signaling;Recycling;Research;response;Rewards;Role;Shapes;Signal Transduction;Slice;Synapses;Testing;Textbooks;tool;Ventral Tegmental Area;Visit

PROJECT_TITLE: Role of novel VTA neurons in addiction-related behaviors

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: MOSCOW

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Project Narrative: Bacteria of the genus Chlamydia cause serious infections including sexually transmitted diseases and the potentially blinding ocular infection, trachoma. All Chlamydiae depend on the transition between an infectious Elementary Body (EB) form and a replicative Reticulate Body (RB) form to cause disease. This project aims to describe the molecular details that regulate cell type differentiation using novel single cell technologies.

PI_NAMEs: GRIESHABER, SCOTT S (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Atherosclerosis;Bacteria;Blindness;cell type;Cells;Chemical Agents;Chlamydia;Chlamydia Infections;Chlamydia trachomatis;Chlamydiaceae;Chlamydiales;Chlamydophila pneumoniae;Chlamydophila psittaci;Complex;CRISPR interference;Data;Development;Dideoxy Chain Termination DNA Sequencing;Disease;Dissection;DNA;Ectopic Expression;Elements;Environment;Essential Genes;Eukaryotic Cell;Eye Infections;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Germination;Guide RNA;Hour;human pathogen;Image;Infection;Infertility;Invaded;knock-down;Life Cycle Stages;Link;member;Modeling;Molecular;Mutation;Nature;novel;obligate intracellular parasite;Operon;Pathogenesis;pathogenic bacteria;Pattern;Pelvic Inflammatory Disease;Phenotype;Pneumonia;Population;Process;Production;promoter;Proteins;Publishing;Regulation;Reporter;Respiratory Disease;Role;Sexually Transmitted Diseases;single cell technology;System;Therapeutic;Trachoma;Vertebrates;Zoonoses

PROJECT_TITLE: Understanding the chlamydial developmental cycle at the single cell level

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Craniofacial skeletal muscle is essential for basic life functions including chewing, swallowing, and speaking; therefore, understanding how this tissue regenerates in response to injury and disease will provide the basis for therapeutic advances in the treatment of craniofacial muscle diseases and disorders. Our group has demonstrated that craniofacial skeletal muscle has the ability to regenerate following damage, but to what extent remains unknown. The goal of this proposal is to comprehensively investigate the regenerative capacity of craniofacial muscle and its stem cell population to inform developments in treatment modalities for individuals suffering from craniofacial muscle injury or disease.

PI_NAMEs: MCKAY, LAUREN KATZ (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Administrative Supplement;Basic Science;Biological Assay;career;Cell Physiology;Cell Transplantation;Clinical;craniofacial;Data;Deglutition;Development;Discipline;Disease;Excision;Face;Facial asymmetry;Goals;In Vitro;in vivo;in vivo Model;Individual;Injury;Investigation;K-Series Research Career Programs;Knock-out;Knowledge;Lentivirus Vector;Life;Limb structure;Manuscripts;Mastication;Mentors;Mentorship;Modality;Modeling;Molecular Target;multidisciplinary;Muscle;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;myogenesis;Myopathy;Natural regeneration;Oral;oral biology;Patients;Phenotype;Population;Preparation;programs;regenerative;Regenerative capacity;Regenerative Medicine;Research;response to injury;Scientist;single-cell RNA sequencing;Skeletal Muscle;skills;stem;stem cell population;Stem cell transplant;stem cells;Techniques;Therapeutic;tissue regeneration;Tissues;Training;translational therapeutics;Trauma;tumor

PROJECT_TITLE: Myogenic Mechanisms of Craniofacial Skeletal Muscle Regeneration


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: FAIRBANKS

ORG_NAME: UNIVERSITY OF ALASKA FAIRBANKS

ORG_STATE: AK

PHR: OH STEM!: Narrative OH STEM! works with tribal partners to create educational opportunities centered in the unique culture and environment of Southeast Alaska for underrepresented rural and Indigneous students. We will bring courses, mentored research projects, and scientists to remote Alaska communities to meet students where they are, while supporting SE Alaska partners to grow their own capacity for STEM education. These culturally centered experiences in their hometowns will develop a foundation of student belonging and resilience as they continue on their science career paths.

PI_NAMEs: CHENOWETH, ELLEN  (contact)

PROJECT_TERMS: Alaska;Alaskan;Awareness;Career Choice;Collaborations;college;Communities;Critical Thinking;cultural values;Data;Development;Disparity;Dual Enrollment;Ecosystem;Education;Environment;experience;Foundations;geographic barrier;Health;High School Student;Home;Indigenous;Institution;Internships;Knowledge;Learning;Lived experience;Mentors;Middle School Student;Pathway interactions;Positioning Attribute;Preparation;remote communities;Research;Research Personnel;Research Project Grants;resilience;Resources;Rural;rural Alaska;rural underrepresented;scaffold;school district;School Teachers;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self Efficacy;skills;stem;STEM career;STEM curriculum;STEM field;student participation;Students;symposium;Thinking;Training;tribal Nation;Tribes;Universities;Work

PROJECT_TITLE: OH STEM! Co-Creating a One Health STEM Ecosystem for Rural and Indigenous Alaska Students.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research

PHR: BRITE Project Narrative We propose the Biotechnology Research Incubator for Teachers (BRITE) program to provide middle school teachers in the Houston area with summer research opportunities, aligning with Next Generation Science Standards and bridging the gap between research experiences, AI- guided literature adaptation, and classroom instruction. With a cohort of 12 teachers in the first year and 16 teachers annually in subsequent years, BRITE aims to enhance science education, empower teachers, and inspire students to pursue STEMM fields, impacting approximately 7,000 middle school students over five years. The program's influence will extend further as trained teachers disseminate knowledge and influence their colleagues, amplifying its reach.

PI_NAMEs: HUANG, SHIXIA  (contact)

PROJECT_TERMS: Address;Area;Artificial Intelligence;Biological Sciences;Biomedical Research;Biotechnology;career;Career Choice;Certification;Charge;Clinical;cohort;college;Compensation;Critical Thinking;design;Development;Disease;Education;Educational process of instructing;Educational workshop;Elements;Eligibility Determination;empowerment;Engineering;Ensure;experience;Face;Faculty;Faculty Recruitment;falls;Feedback;follow-up;Fostering;Future;Grant;hands on research;hands-on learning;hatching;Income;Incubators;Inequality;innovation;Institution;Instruction;junior high school;Knowledge;Laboratories;laboratory equipment;Laboratory Research;Learning;Literature;Location;Mathematics;Medicine;Mentors;Middle School Faculty;Middle School Student;next generation;Next Generation Science Standards;Outcome;Participant;payment;Play;Positioning Attribute;Price;Problem Solving;programs;Readability;Reading;recruit;Relaxation;Research;research facility;Role;Rotation;Schedule;school district;Schools;Science;science education;science teacher;science, technology, engineering, mathematics, and medicine;Scientific Advances and Accomplishments;Scientist;Shapes;skills;Solid;statistics;STEM field;Structure;Students;success;summer research;Surveys;teacher;Teacher Professional Development;Technology;Texas;Time;tool;Training;Translating;volunteer;Work

PROJECT_TITLE: Biotechnology Incubator for Teachers (BRITE)


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Hematology;Pediatric;Rare Diseases;Sickle Cell Disease

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Elevating Mentoring Possibilities for Overcoming Withstanding Educational Roadblocks in Sickle Cell Disease (EMPOWER SCD): STEMM mentoring for youth with sickle cell disease The goal of this work is to create a near-peer mentorship program for youth with sickle cell disease to increase the likelihood of pursuing post-secondary education and careers in STEMM (medicine) fields. EMPOWER SCD will connect youth with biomedical engineering educational experiences, teaching and learning opportunities, and STEMM identity formation activities. This work will positively impact the student’s educational aspiration, interest in STEMM subjects, STEMM identity, and drive them to become future researchers, physicians, and engineers. 1

PI_NAMEs: GEE, BEATRICE E (contact);HARDY, ELAISSA L

PROJECT_TERMS: 14 year old;18 year old;Achievement;Address;Adolescent;Affect;Africa South of the Sahara;African ancestry;Anemia;Area;Asia;aspirate;Behavior;Biomedical Engineering;blood vessel occlusion;career;Caring;Categories;Characteristics;Child;Chronic;Clinic;Clinic Visits;Cognitive;cohort;college;design;Development;Disabling;Disabling condition;Education;Educational Curriculum;Educational process of instructing;educationally disadvantaged;effectiveness evaluation;Emotions;empowerment;Engineering;Equity;Executive Dysfunction;experience;Exposure to;Fostering;Future;Gender;Goals;Growth;Health Occupations;Health Professional;Hematological Disease;High School Student;Hospitalization;Impairment;improved;inattention;Individual;Inherited;innovation;Institution;Intelligence;interest;junior high school;Knowledge;Learning;Malaria;Mathematics;Medical;medical appointment;Medical center;medical schools;Medical Students;Medicine;meetings;member;Mentors;Mentorship;Methods;Middle School Student;minority children;Morehouse School of Medicine;Motor;organ injury;Outcome;Pain;Participant;Pediatric Hospitals;peer;peer coaching;Performance;Persons;Physicians;Problem Solving;professional students;programs;Psychosocial Assessment and Care;Race;racial minority population;Reaction;recruit;Relationship-Building;Research Personnel;Risk;role model;School-Age Population;Schools;Science;science education;science, technology, engineering, mathematics, and medicine;Scientist;secondary outcome;Secondary Schools;Sickle Cell Anemia;Site;skills;social;Societies;Speed;STEM field;Students;Technology;Teenagers;therapy adverse effect;Time;Trainers Training;Training;Training Programs;Trust;Underachievement;undergraduate student;Universities;university student;Work;Youth


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Obesity;Clinical Research;Data Science;Kidney Disease;Obesity;Pediatric;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: Project Narrative The Biomedical Engineering Superheroes program is anticipated to foster interest in Biomedical engineering and Clinical research in young learners from underserved communities and underrepresented minorities. This program seeks to produce the next generation of STEM field professionals with the potential to contribute to science from diverse perspectives due to the emphasis on representation and inclusion. We will include curricular units that demonstrate how Biomedical Engineering Superheroes fight against four common conditions or diseases that align to four of the mission areas (the fantastic four) of the NIH Institutes and Centers- obesity, diabetes, heart disease, and kidney disease based on data that demonstrated how prevalent and thus culturally relevant these public health issues are to families.

PI_NAMEs: MARTINEZ ORTIZ, ARACELI  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Active Learning;Address;aged;Area;Biomedical Engineering;career;Chronic Kidney Failure;Clinical Research;Cognitive;college;Communities;Community Health;curriculum development;Data;Data Science;Dedications;design;Development;Diabetes Mellitus;Disease;Education;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Engineering;engineering design;ethnic minority;Event;experience;Exposure to;Family;Family member;Feedback;fifth grade;fighting;Fostering;Funding;Goals;Health Fairs;Health Sciences;Heart Diseases;high school;High School Student;Hispanic;Hispanic Populations;Hour;Human Development;informal learning;Instruction;interest;Intervention;Kidney Diseases;Knowledge;Language;Latino Population;Lead;Learning;learning strategy;Linguistics;Longitudinal Studies;Low income;Mathematics;Measures;Medical;Methods;Middle School Student;Mission;model development;multidisciplinary;next generation;Obesity;Output;outreach;outreach program;Parents;pedagogical content;peer coaching;Persons;Primary School Faculty;Problem Solving;Professional Education;programs;Public Health;Reading;Research;research and development;Resources;school district;Schools;Science;Science, Technology, Engineering and Mathematics Education;skills;social;Social Impacts;Societies;STEM career;STEM field;student participation;Students;success;teacher;Teacher Professional Development;Technology;theories;Training;Underrepresented Minority;underserved community;United States National Institutes of Health;university student;Work

PROJECT_TITLE: BIOMEDICAL ENGINEERING SUPERHEROES: Health Science, Engineering, and Data Science Elementary Curriculum Development & Outreach Program


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: EDWARDSVILLE

ORG_NAME: SOUTHERN ILLINOIS UNIV AT EDWARDSVILLE

ORG_STATE: IL

PHR: Project Narrative A diverse health workforce representative of the US population is needed to ensure that everyone has access to  quality and relevant healthcare. Increasing high school students' social capital, that is, their access to  information and resources about health careers and effective mentorship, will help reduce barriers to entering  health professional school and becoming a healthcare practitioner. This project will develop and implement a  problem-based, four-year medical curriculum and multi-level mentoring network for 70 high school students  to give them the essential skills for pursuing a career in healthcare.

PI_NAMEs: LOCKE, SHARON  (contact);TORRY, DONALD S.

PROJECT_TERMS: Access to Information;career;Career Choice;cohort;college;cultural competence;design;Development;disparity reduction;Education;education pathway;education research;Educational Curriculum;Educational Intervention;Ensure;Equity;Ethnic Origin;evidence base;experimental study;Exposure to;Face;Family;follow-up;Gender;Goals;Health;health care quality;Health education;Health Occupations;Health Personnel;Health Professional;Healthcare;high school;High School Faculty;high school program;High School Student;Household;Illinois;Improve Access;Inherited;Institution;interest;Knowledge;Location;Low income;Medical;Medical Education;medical schools;Medical Students;Mentors;Mentorship;Methods;minority student;novel;novel strategies;Outcome;Participant;Pathway interactions;pedagogy;peer;peer coaching;Persons;Physicians;Population;prevent;Problem-Based Learning;professional students;programs;Race;racial diversity;Research;Research Personnel;Resources;Schools;Self Efficacy;skill acquisition;skills;social capital;Societies;Structure;Students;success;systemic barrier;Talents;teacher;Testing;theories;Time;undergraduate student;Universities;university student;Work

PROJECT_TITLE: Increasing High School Student Social Capital for Success in Health Professions


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Herpes simplex viruses (HSV) 1 and 2 cause lifelong infections in most of the human population and represent a heavy burden on human health. New curative treatments are critically needed, and we are developing a novel therapeutic strategy against herpesviruses, using engineered “gene drive” viruses that replace wild-type viruses with an attenuated version and reduce viral levels. In this innovative application, we propose to test if our strategy can inactivate wild-type viruses and prevent viral shedding in mouse models of HSV-1 infection, paving the way toward new curative treatments for chronic HSV diseases.

PI_NAMEs: WALTER, MARIUS  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: adenovirus mediated delivery;anterograde transport;Anti-viral Agents;Area;Attenuated;Autonomic ganglion;Axon;Axonal Transport;Biology;Cells;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;CRISPR/Cas technology;curative treatments;Cytomegalovirus;Defective Viruses;design;Development;Diploidy;Disease;DNA Viruses;Engineered Gene;Engineering;Epithelial Cells;Event;experimental study;Eye Infections;Face;Frequencies;Ganglia;Genes;Genetic;Genetic Recombination;Genitalia;Goals;Grant;Health;Herpes encephalitis;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;homologous recombination;Human;Human Herpesvirus 2;Impairment;improved;In Vitro;in vivo;Infection;infection rate;innovation;Innovative Therapy;Insecta;invention;Label;latent infection;Lesion;mathematical model;Measures;Methods;Modification;mouse model;Mucous Membrane;Mus;Nervous System;Neurons;novel;novel therapeutic intervention;novel therapeutics;nuclease;Organism;Parents;Patients;Pharmaceutical Preparations;Population;prevent;Primary Infection;Recurrent disease;Research;Sensory Ganglia;Sexual Reproduction;Simplexvirus;success;superinfection;Surface;System;Technology;Testing;Therapeutic;therapeutic evaluation;Vaccines;Viral;Viral Genes;Viral Interference;viral outbreak;Virion;Virus;Virus Diseases;Virus Shedding;Work

PROJECT_TITLE: Viral gene drive as a novel curative therapy for HSV infection

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Aging;Bioengineering;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: NARRATIVE An optical module that scans millions of lines per second was combined with two-photon fluorescence microscopy to record neural activity at kilohertz frame rates. Further optimizations of this module, including hardware stabilization, software integration, and implementations in novel microscopy modalities will be pursued to maximize its accessibility and achieve robust large-scale recording of neural activity.

PI_NAMEs: JI, NA  (contact)

PROGRAM_OFFICER_NAME: PUCAK, MICHELE LYNN

PROJECT_TITLE: Optimizing FACED for robust large-scale activity recording

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders D Study Section[NSD-D]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Primary Health Care;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The proposed study will use multiple methods to study how language discordance affects hospital nursing practice with persons with limited English proficiency (LEP) (approximately 20% of the US population and includes deaf persons) and may contribute to inequitable outcomes associated with hospitalization. The study’s scientific premises are that a) communication barriers between clinicians and patients are a social determinant of health that contribute to health inequities; b) the sources of inequities in hospital-based outcomes for LEP patients are all nurse-sensitive; c) hospital nurses and their practices in relation to bridging language barriers are the most under- studied area of practice despite having the highest volume of contact with LEP patients; and d) practice guidelines for nurses and their employers about “essential” times to use language services are vague and not well specified. The findings from this study will help to reduce inequities in hospitalization associated outcomes amongst LEP persons.

PI_NAMEs: SQUIRES, ALLISON P (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Accident and Emergency department;Address;Admission activity;Adverse event;Affect;Affordable Care Act;Area;bilingualism;care delivery;Care given by nurses;Caring;Censuses;clinical practice;cognitive interview;Communication;Communication Barriers;Country;Data;deaf;Decision Making;decubitus ulcer;design;Development;Discipline of Nursing;Discipline of obstetrics;Electronic Health Record;experience;falls;Goals;graduate student;health equity;health inequalities;health outcome disparity;Health Services Research;Health system;Healthcare;Home;Home Care Services;Hospital Nursing;Hospital Nursing Staff;hospital readmission;Hospitalization;Hospitals;Household;improved;improved outcome;Inequity;Infection;instrument;Intervention;Interview;Justice;Language;Laws;Length of Stay;life span;Limited English Proficiency;Linguistics;Link;Literature;Measures;Medical;Medication Errors;meetings;Methods;Modeling;National Institute of Nursing Research;New York;Nurses;Nursing Assessment;Operative Surgical Procedures;Outcome;outcome disparities;Participant;Patient Self-Report;Patient-Focused Outcomes;Patients;Pediatrics;Perioperative;Persons;Phase;pilot test;Planning Theory;point of care;Policies;Population;Population Heterogeneity;Practice Guidelines;preference;Primary Care;Psychiatry;Psychometrics;Qualitative Methods;readmission risk;recruit;Reporting;Research;Research Methodology;Research Priority;Research Proposals;research study;Risk;Sampling;Self Assessment;Services;social health determinants;Source;Specific qualifier value;Standardization;structural determinants;Structure;suburb;Surgical Wound Infection;Surveys;System;Techniques;theories;therapy development;Time;tool;Trust;Uncertainty;United States;Universities;Urban Hospitals;Validation;Validity and Reliability;Water;Work

PROJECT_TITLE: A Multiple Methods Study to Understand Hospital Nurses Practices Accessing Language Services to Address Language Preference Associated Health Inequities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Candida glabrata is a yeast pathogen of increasing importance in the clinic, due in part to its ability to acquire resistance to antifungal drugs. This proposal is aimed at understanding how resistance develops using C. glabrata strains isolated from patients.

PI_NAMEs: MOYE-ROWLEY, W SCOTT (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Alleles;Amphotericin B;Animals;anti-fungal agents;Antifungal Therapy;Azole resistance;Azoles;Binding;Candida;Candida albicans;Candida glabrata;candidemia;Candidiasis;Caspofungin;Categories;CDR1 gene;Cells;chemotherapy;Clinic;Clinical;clinical practice;Collection;combat;Data;Defect;Development;Disease;Disseminated candidiasis;Drug Efflux;efflux pump;Enzymes;Exhibits;experimental study;FDA approved;Fluconazole;Fluconazole resistance;Foundations;Fungal Drug Resistance;Fungal Genes;gain of function;gain of function mutation;Gene Expression;Genes;Genetic Transcription;Genome;genome analysis;genome sequencing;Growth;In Vitro;in vivo;Incidence;Infection;insight;Knowledge;Mediating;minimal inhibitory concentration;Minor;Mitochondria;Molecular;Molecular Analysis;mortality;mouse model;Mus;mutant;Mutation;Mycoses;Nosocomial Infections;novel;Organism;Outcome;overexpression;pathogen;pathogenic fungus;Pathogenicity;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physiology;Play;Polyenes;Predisposition;prevent;Proteins;Publications;Resistance development;Resolution;response;Risk;RNA;Role;Sepsis;Techniques;Time;transcription factor;transcriptome;transcriptome sequencing;Uncertainty;United States;Western Blotting;whole genome;Work;Yeasts

PROJECT_TITLE: Novel mechanisms of azole resistance in clinical isolates of Candida glabrata


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Down Syndrome;Genetics;Human Fetal Tissue;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Down syndrome (DS) is a developmental genetic condition caused by trisomy of human chromosome 21. DS occurs in approximately 1 in 600-1000 live births and is estimated to affect more than 300,000 individuals in the USA. Neuropathological and clinical features of Alzheimer’s disease (AD) present early in life through the sixth decade, and include amyloid plaques, neurofibrillary tangles, NGF dysmetabolism and cholinergic basal forebrain degeneration, CNS inflammation, and cognitive decline leading to AD dementia. Despite the molecular and genetic similarities between AD and DS, there exists a paucity of information on the biological mechanisms underlying the onset of cognitive decline in adults with DS. Responding to the INCLUDE initiative, the overall goal of this proposal is to investigate pathophysiological mechanisms and novel biomarkers in different stages of AD in DS. The proposed studies use a multidisciplinary and complementary approach, which includes biochemical analysis of plasma, CSF, and extracellular vesicles (EVs), neuropathological assessments, trancriptomics, proteomics, in vitro cellular/molecular analyses, and a well-characterized cohort of DS individuals to uncover the molecular pathobiological progression of AD in DS. This powerful combination of neuropathological, cellular, and clinical studies using the same biomarkers will lead to a detailed characterization of AD stages that will enable a precision medicine approach that will inform future preventive trials and assist in the prediction of the onset and evolution of AD dementia and in the identification of novel therapeutic targets in this vulnerable population.

PI_NAMEs: BUSCIGLIO, JORGE A (contact);CUELLO, A CLAUDIO;FORTEA, JUAN ;WISNIEWSKI, THOMAS M

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adult;Affect;Age;age acceleration;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloidosis;Astrocytes;Autopsy;basal forebrain;Biochemical;Biological;Biological Markers;Biological Models;biomarker identification;Body Fluids;Brain;Brain region;brain tissue;California;Canada;cholinergic;Chromosome 21;Clinical;Clinical Research;cohort;Collaborations;Data;Dementia;Development;developmental genetics;Down's Syndrome;entorhinal cortex;Event;Evolution;extracellular vesicles;frontal lobe;Functional disorder;Future;Genetic;Genetic Diseases;Genetic Models;Genetic Transcription;Goals;Hippocampus;Hospitals;Human;Human Chromosomes;Image;imaging biomarker;Immune;Impaired cognition;In Vitro;Individual;Inflammation;Life;Liquid substance;Live Birth;Metabolic dysfunction;Metabolism;Methods;Modeling;Molecular;Molecular Analysis;molecular targeted therapies;multidisciplinary;multimodality;Nerve Degeneration;Nerve Growth Factors;Neurofibrillary Tangles;neuroinflammation;Neurons;neuropathology;new therapeutic target;New York;novel marker;novel strategies;Pathogenesis;Pathology;Pathway interactions;patient population;Patients;Persons;Plasma;precision medicine;Preventive;Preventive Clinical Trial;Proteins;Proteomics;Publishing;Research;Role;Senile Plaques;single-cell RNA sequencing;Spain;Study models;targeted biomarker;tau Proteins;Testing;Thick;transcriptomics;treatment response;Trisomy;Universities;Vulnerable Populations

PROJECT_TITLE: The role of immune deregulation and NGF dysmetabolism in the development of Alzheimer disease in individuals with Down syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-B (57)]


NIH_SPENDING_CATS: Asthma;Lung

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Studies proposed in this competitive renewal application seek to define new roles for hematopoietic cell- expressed 12/15-lipoxygenase and the TCA cycle metabolite itaconate in immunologic and physiologic responses during allergic fungal asthma.

PI_NAMEs: STEELE, CHAD  (contact)

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: 12-HETE;Ablation;acidic mammalian chitinase;Aconitic Acid;airway hyperresponsiveness;Allergic;anakinra;Anti-Asthmatic Agents;anti-fungal agents;Anti-Inflammatory Agents;Arachidonate 15-Lipoxygenase;Arachidonate 5-Lipoxygenase;Arachidonic Acids;Aspergillus fumigatus;Asthma;asthmatic;Automobile Driving;Award;Basophils;Bone Marrow;Carboxy-Lyases;CD59 Antigen;cell type;Cells;chemokine;Chimera organism;Chitinase;Citric Acid Cycle;Collaborations;CX3CL1 gene;Data;Dendritic Cells;Development;Diamond;eicosanoid metabolism;Enzymes;eosinophil;Equilibrium;Extrinsic asthma;Fatty Acids;FDA approved;Flow Cytometry;fungus;Generations;Hematopoietic;IL7 gene;Immune Response Genes;Immunologics;immunoregulation;Inflammatory;Inflammatory Response;Interleukin-1 alpha;Interleukin-1 beta;ITGAX gene;Leukotriene Antagonists;Leukotrienes;lipidome;lipidomics;Lipids;Lipoxins;LoxP-flanked allele;Lung;Macrophage;mast cell;Mediating;Mediator;Messenger RNA;Metabolism;metabolomics;montelukast;Mus;Myeloid Cells;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;neutrophil;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Pathway interactions;Physiological;Regulation;Reporter;response;Role;Severities;Severity of illness;Supplementation;Therapeutic;therapeutic target;tool;Universities;Washington;Wild Type Mouse;Work;Zileuton

PROJECT_TITLE: Immunopathogenesis in fungal asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-E (03)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Human craniofacial development is a complex process and requires suites of genes to be switched on and off at appropriate times and spaces during formation of the embryo. There is now a wealth of data available in public databases concerning which genes are expressed when and where during mammalian facial development, including for the transcription factors which are the proteins that regulate these critical expression programs, but we have not yet begun to connect this information together to derive logical predictions about the critical networks responsible for craniofacial development. This proposal will address that gap using both computational and laboratory-based methods to derive and verify transcriptional regulatory networks relevant to the genetic and molecular underpinnings of normal facial development as well as how these are disrupted to cause defects such as human orofacial clefting.

PI_NAMEs: LI, HONG  (contact)

PROJECT_TERMS: Acceleration;Adopted;Affect;Age;ATAC-seq;Automobile Driving;Bioinformatics;Biological Assay;Biological Models;Biology;bone;career;career development;Cartilage;cell type;Cells;ChIP-seq;Complex;Computational Science;Computer Models;Congenital Abnormality;craniofacial;craniofacial development;critical period;Data;Data Science;Data Set;Databases;Defect;Dental;Dependence;design;Development;Development Plans;differential expression;Ectoderm;Embryo;Enhancers;Face;FaceBase;Faculty;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Genomics;Goals;Growth;Histones;Human;Human Genetics;in silico;interest;Knowledge;Laboratories;Learning;Live Birth;Machine Learning;medical specialties;Mentors;Mentorship;Mesenchymal;Mesenchyme;Methods;Molecular;Morphogenesis;mouse model;Multiomic Data;Mus;Muscle;Mutant Strains Mice;National Institute of Dental and Craniofacial Research;network models;next generation;Oral;orofacial cleft;Pathology;Pattern;Performance;Population;Positioning Attribute;Process;programs;promoter;Proteins;public database;recruit;Regulatory Element;Research;Resources;Scientist;Signal Pathway;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Solid;spatiotemporal;Study models;System;Techniques;Technology;tenure track;Tissues;transcription factor;transcription regulatory network;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transgenic Organisms;Validation

PROJECT_TITLE: Transcriptional Regulatory Networks of Craniofacial Development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]