NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lyme Disease;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE Bacteria belonging to the Borrelia genus include Borrelia burgdorferi which is an infectious tick-borne spirochete that causes nearly 300,000 cases of Lyme disease in the United States annually. Borrelia are also known to cause other serious vector-borne human illnesses including relapsing fever and Borrelia miyamotoi disease. In this project is we will use structural, biochemical, and microbiological approaches to study a group of evolutionarily-related, multi-functional, borrelial lipoproteins with the goal of understanding their role in promoting bacterial survival and persistence in immunocompetent hosts.

PI_NAMEs: GARCIA, BRANDON LEE (contact)

PROJECT_TERMS: Ablation;Address;Affinity;Amino Acids;Animal Model;Antibodies;arm;Asia;Bacteria;Binding;Biochemical;Biological;Biological Assay;biophysical techniques;Biophysics;Borrelia;Borrelia afzelii;Borrelia burgdorferi;Borrelia burgdorferi Group;Borrelia garinii;Borrelia Infections;Borrelia miyamotoi;Borrelia turicatae;Classical Complement Pathway;Clinical;Communicable Diseases;Complement;Complement 1q;Complement Activation;Complement component C1r;complement deficiency;complement pathway;complement system;Complex;Cytolysis;Data;design;Disease;disease model;Etiology;Europe;Event;Experimental Designs;Experimental Models;Family;Genes;Genetic;Goals;Hematogenous;Homologous Gene;Human;human disease;imaging approach;Immune;Immunity;Immunocompetent;Immunomodulators;immunoregulation;Impairment;In Vitro;in vitro activity;in vivo;in vivo imaging;in vivo Model;Infection;inhibitor;interdisciplinary approach;Life Cycle Stages;Lipoproteins;Lyme Disease;lyme pathogenesis;Lytic;Measures;Mediating;Medical;Microbe;Minor;Modeling;Molecular;mouse model;multidisciplinary;Mus;mutant;Natural Immunity;Nature;Order Spirochaetales;Orthologous Gene;pathogen;Pathogenesis;Pathway interactions;Pattern Recognition;Peptide Hydrolases;Phenotype;Phylogenetic Analysis;Play;Predisposition;Proteins;Reaction;Relapsing Fever;relapsing fever borrelia;Reporting;Resolution;Role;Serum;Spirochaetales Infections;Structure;Surface;Testing;tick borne spirochete;Ticks;United States;vector-borne;vector-borne pathogen;Vector-transmitted infectious disease;Virulence;X-Ray Crystallography

PROJECT_TITLE: Virulence Mechanisms of Multifunctional Borrelial Proteins

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ACTIVITY: ZIF

ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Substance Misuse

PROJECT_TITLE: NIAAA CCMF allocation


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research

ORG_NAME: NATIONAL INSTITUTE ON AGING

PROJECT_TITLE: NIA CCMF allocation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TITLE: NIAID CCMF allocation


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research

PROJECT_TITLE: NIAMS CCMF allocation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PROJECT_TITLE: NCI CCMF allocation


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PROJECT_TITLE: CC CCMF allocation


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PROJECT_TITLE: NIDA CCMF allocation


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PROJECT_TITLE: NIDCD CCMF allocation


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease

PROJECT_TITLE: NIDCR CCMF allocation


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PROJECT_TITLE: NIDDK CCMF allocation


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PROJECT_TITLE: NIBIB CCMF allocation


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PROJECT_TITLE: NIEHS CCMF allocation


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision

ORG_NAME: NATIONAL EYE INSTITUTE

PROJECT_TITLE: NEI CCMF allocation


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PROJECT_TITLE: NIGMS CCMF


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TITLE: NICHD CCMF allocation


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

PROJECT_TITLE: NHGRI CCMF allocation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PROJECT_TITLE: NHLBI CCMF allocation


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

PROJECT_TITLE: NIMHD CCMF allocation


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Clinical Research;Mental Health

ORG_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

PROJECT_TITLE: NIMH CCMF allocation


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

ORG_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

PROJECT_TITLE: NINR CCMF allocation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PROJECT_TITLE: NINDS CCMF allocation


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PROJECT_TITLE: NCATS CCMF allocation


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: HINES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Grasping is impaired in a number of individuals with cervical spinal cord injury. This proposal aims to examine the contribution of physiological pathways involved in grasping behaviors, and to maximize the recovery of grasping by using tailored non-invasive stimulation protocols with motor training. Novel methods will be used to strengthen transmission in residual corticospinal and reticulospinal connections and to enhance voluntary control of hand muscles. Because deficits in hand control are a major problem after stroke, amyotrophic lateral sclerosis, multiple sclerosis, and other motor disorders, our work may also be relevant for individuals with other lesions of the CNS.

PI_NAMEs: PEREZ, MONICA A (contact)

PROJECT_TERMS: Acoustics;Affect;Amyotrophic Lateral Sclerosis;Animals;Area;Behavior;Behavioral;Brain;Brain Stem;Caregivers;Caring;Cervical spinal cord injury;Cervical spinal cord structure;Data;Dorsal;Eating;Effectiveness;experimental study;finger movement;Fingers;Functional Magnetic Resonance Imaging;Future;Goals;grasp;Hand;Hand functions;hand rehabilitation;Human;Impairment;improved;indexing;Individual;Injury;Intervention;Investigation;Knowledge;Lesion;Life;Loudness;Measures;Methods;Motor;Motor Cortex;motor disorder;Motor Evoked Potentials;motor impairment;Movement;Multiple Sclerosis;Muscle;Neuronal Plasticity;Neurons;noninvasive brain stimulation;novel;novel strategies;operation;Outcome;Output;Pathway interactions;Persons;Physiologic pulse;Physiological;post stroke;Protocols documentation;Quality of life;Reaction Time;Recovery;rehabilitation strategy;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Residual state;skills;Spinal cord injury;Sterile coverings;Stimulus;success;Testing;Time;Training;Transcranial magnetic stimulation;transmission process;Veterans;Work;Writing

PROJECT_TITLE: Grasping Function after Spinal Cord Injury

STUDY_SECTION: RRDA

STUDY_SECTION_NAME: Spinal Cord Injury/Disorders & Neuropathic Pain[RRDA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PI_NAMEs: CHODERA, JOHN DAMON (contact);LEE, ALPHA ALBERT;SJÖ, PETER

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TERMS: 2019-nCoV;Acceleration;Administrative Efficiency;Anti-viral Agents;Biological Assay;Biology;Chemicals;Chemistry;clinic ready;clinical translation;clinical trial readiness;Collaborations;combat;Communication;Communities;Complement;Complex;computational chemistry;Coronavirus;cost efficient;COVID-19;dashboard;Data;data infrastructure;Decision Making;Dedications;design;Development;Diamond;Disease;drug discovery;Elements;Ensure;Epidemic;epidemic virus;Equity;experience;Family;Family Picornaviridae;Flavivirus;Free Energy;Funding;Future;future pandemic;Generations;Goals;Home;industry partner;innovation;Investigational New Drug Application;Investments;Lead;lead optimization;Leadership;Letters;Libraries;Light;Link;London;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;mutation screening;nanoscale;National Institute of Allergy and Infectious Disease;neglect;new technology;novel;novel strategies;Occupational Medicine;open data;operation;Oral;Output;pandemic disease;pandemic potential;pandemic preparedness;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;pre-clinical;preclinical development;preclinical study;Productivity;programs;Reagent;recruit;Refractory;Research;Research Contracts;Research Personnel;Research Project Grants;resilience;Resistance;Resources;RNA Viruses;Roentgen Rays;SARS-CoV-2 antiviral;Seasons;Secure;Source;structural biology;Structure;Technology;Therapeutic;therapeutically effective;tool;Translations;Trust;Viral;Viral Physiology;virology;Work

PROJECT_TITLE: AI-driven Structure-enabled Antiviral Platform (ASAP)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: CHODERA, JOHN DAMON (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Anti-viral Agents;anti-viral efficacy;antiviral drug development;base;Biochemical;Biological Assay;Biological Availability;Biology;Cellular Assay;Clinic;Clinical;cloud based;Collaborations;computational chemistry;Coronavirus;cost;COVID-19;Crystallization;Crystallography;Data;data infrastructure;Data Set;data sharing;Databases;design;Development;Disclosure;Dose;Drug Design;Drug Interactions;Drug resistance;Educational process of instructing;Ensure;experience;Family;Family Picornaviridae;Flaviviridae;Free Energy;future pandemic;Goals;Human;improved;In Vitro;in vivo;Industrialization;Industry;Infrastructure;Knowledge;Lead;lead optimization;lead series;Ligands;Link;Literature;Logistics;Manufacturer;Measurable;Measurement;member;Methods;Modeling;Mutation;mutation screening;Nature;novel;open data;Oral;Output;pandemic preparedness;Patients;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase;pre-clinical;preclinical development;Procedures;Process;process optimization;programs;Property;Protease Inhibitor;Proteins;Protocols documentation;Publications;Publishing;Rattus;Readiness;Reagent;Resistance;Resources;Roentgen Rays;Route;Safety;Sampling;scale up;screening;Secure;Serial Passage;small molecule;Source;structural biology;Structure;Structure-Activity Relationship;Technology;Testing;Time;Toxic effect;Translations;Veterans;Viral;Viral Physiology;Work

PROJECT_TITLE: Lead optimization


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Natural Products;Neurosciences;Pain Research;Physical Rehabilitation;Rehabilitation;Urologic Diseases;Women's Health Research

ORG_CITY: KATY

ORG_NAME: HILLMED INC

ORG_STATE: TX

PHR: Project Narrative Chronic pelvic pain (CPP) is a debilitating condition that negatively impacts the social and sexual quality of life in up to 20% of American women. Botulinum neurotoxin (BoNT) has received growing interest in managing CPP, but it can cause dose-dependent side- effects and is expensive. This FastTrack SBIR project aims to develop a commercializable, personalized, precision BoNT injection medical device, i.e., the PelviMap system, implementing validated vaginal HD-sEMG technology to optimize the treatment outcomes in CPP management.

PI_NAMEs: DIAS, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Abdomen;Acetylcholine;Address;Adverse effects;Affect;Age;Algorithms;American;Atopobium vaginae;botulinum neurotoxin injection;botulinum toxin treatment;Botulinum Toxins;chronic pelvic pain;Clinical;Clinical Trials;Clinical Trials Design;Collaborations;college;commercial application;commercialization;Computer software;cost;Crossover Design;Data;density;design;Devices;Diagnosis;Diagnostic;diagnostic platform;digital;Dose;effective therapy;Effectiveness;efficacy evaluation;Electrodes;Electromyography;Elements;Etiology;Face;Feedback;Focus Groups;Friends;Human;improved;Injection of therapeutic agent;Injections;interest;Interstitial Cystitis;invention;Legal patent;Licensing;Manometry;Manuals;Maps;Marketing;Measurement;Medical;Medical Device;Medicine;Muscle;Muscle relaxation phase;Muscle Spasticity;nerve supply;Neuromuscular Junction;neuromuscular transmission;novel;Pain;Pain management;Patients;Pelvic Examination;Pelvic Floor Muscle;Pelvic floor structure;Pelvis;Performance;Persistent pain;Phase;Physical therapy;Physicians;Quality of life;Randomized;recruit;Research;Resolution;Safety;Severities;side effect;Small Business Innovation Research Grant;social;soft tissue;Software Validation;Surface;System;Techniques;technological innovation;Technology;Testing;Therapeutic Effect;Therapeutic Intervention;Time;Training;Treatment Efficacy;treatment optimization;Treatment outcome;treatment strategy;Treaty;Universities;usability;Vagina;Woman;women's diagnosis;women's treatment

PROJECT_TITLE: An Novel Medical System for Quantitative Diagnosis and Personalized Precision Botulinum Neurotoxin Injection in Chronic Pelvic Pain Management


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_DEPT: BIOLOGY

ORG_NAME: HUNTER COLLEGE

PHR: PROJECT NARRATIVE Overall The underserved vulnerable African American, Asian-Pacific American and Hispanic American populations in the PA-NJ-NYC region experience significant cancer-related health disparities across the cancer continuum, from a higher prevalence of cancer risk factors to delayed screening and diagnoses, experiencing more advanced disease, and poorer outcomes. SPEECH has made significant strides toward transforming cancer health disparities research and education; research infrastructure and platforms that enabled investigators to advance cancer health equity in these underrepresented and underserved populations. In the next five years, our Partnership aims to advance cancer health disparities research, training/workforce development, and community-informed interventions by breaking structural, systemic barriers and promoting inclusive excellence across disciplines among basic, clinical and population science researchers, trainees and diverse underserved communities

PI_NAMEs: ERBLICH, JOEL  (contact);FORD, JENNIFER S;MA, GRACE X.;RAGIN, CAMILLE C.;WULTSCH, CLAUDIA

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Address;advanced disease;Advanced Malignant Neoplasm;African American;anti-cancer research;Area;Asian Americans;Asian Pacific American;aspirate;Basic Science;bench to bedside;Bioinformatics;Biometry;Black race;cancer education;cancer health disparity;Cancer health equity;Cancer Intervention;cancer prevention;cancer risk;career development;Career Mobility;Clinical Sciences;Collaborations;college;Communities;community based participatory research;community engaged approach;community engaged intervention;community engagement;Community Health Aides;community organizations;Community Outreach;Competence;Comprehensive Cancer Center;County;COVID-19 pandemic;Data;Death Rate;Diagnosis;Discipline;Doctor of Philosophy;Education;education research;Equity;ethnic minority;Evaluation;evidence base;experience;Faculty;Feedback;Fostering;Foundations;Fox Chase Cancer Center;Funding;Grant;Health;Health Disparities Research;Health equity research;High Prevalence;Hispanic Americans;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Malignant Neoplasms;member;Mentors;Mentorship;Methods;Minority;Modeling;Monitor;mortality;multidisciplinary;Needs Assessment;Neighborhoods;next generation;Outcome;outreach;outreach program;Pilot Projects;Population;Population Sciences;Positioning Attribute;Poverty;programs;Publications;racial minority;Recommendation;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Schools;Science;Scientist;screening;skills;social determinants;Societies;Strategic Planning;structural determinants;Students;success;systemic barrier;Target Populations;Training;translational approach;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Vision;Workforce Development

PROJECT_TITLE: (2/2) TUFCCC/HC Regional Comprehensive Cancer Health Disparities Partnership


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Humans can show tremendous flexibility in every day life, rapidly recognizing and responding to contextual cues with appropriate behavioral changes, even in unfamiliar situations where the appropriate behaviors could not have been learned through direct experience. Here we examine the neural basis of this flexibility, with a particular focus on how arousal signals elicited by perceived context changes might coordinate neural representations in the brain to facilitate appropriate behaviors in changing and unfamiliar situations. This work will provide an understanding of how the brain generates flexible behavior, and why it does so differently in different individuals, thereby serving as a foothold for future work seeking to understand what goes wrong in conditions characterized by failure to cope with uncertain and changing environments.

PI_NAMEs: NASSAR, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Accidents;Adopted;Affect;Algorithms;Anxiety Disorders;Arousal;Attention deficit hyperactivity disorder;Attentional deficit;automobile accident;Basic Science;Behavior;behavior influence;behavior prediction;Behavioral;Brain;Cognitive;Complex;computational neuroscience;computer framework;Computer Models;coping;COVID-19;Cues;Data;Dependence;design;Diameter;Effectiveness;Electroencephalography;Environment;EP300 gene;Etiology;experience;experimental study;Failure;flexibility;Functional Magnetic Resonance Imaging;Future;Goals;Human;Impairment;Individual;Individual Differences;Instruction;inter-individual variation;Learning;learning algorithm;Life;Link;locus ceruleus structure;Masks;Measures;Mediating;Mental disorders;Mental Health;Modeling;Nature;neural;neuromechanism;Norepinephrine;norepinephrine system;novel;Participant;Pattern;Peripheral;personalized predictions;Persons;Pharmaceutical Preparations;pharmacologic;Play;Policies;post-COVID-19;predictive modeling;Process;Proxy;Pupil;research study;response;Reversal Learning;Rodent;Role;Signal Transduction;Structure;Testing;theories;therapeutic target;Time;tool;Update;validation studies;Work

PROJECT_TITLE: Representational dynamics for flexible learning in complex environments

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Infectious Diseases

ORG_CITY: SANTA CRUZ

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: The proposed research is relevant to public health and specifically to NIH’s mission to seek fundamental knowledge about the behavior of living systems and apply that knowledge to enhance health and reduce the burden of disease. Our experiments will fill a gap in our understanding of basic Helicobacter pylori physiology and metabolism during the chronic growth state. This work will pave the way for new treatments that enhance antibiotic cure of H. pylori.

PI_NAMEs: OTTEMANN, KAREN M (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Adopted;Affect;Amoxicillin;Antacids;Antibiotics;Bacteria;Behavior;Biochemistry;burden of illness;Cancer Etiology;Carbon;Cessation of life;Chronic;chronic infection;Chronic Phase;Clarithromycin;Colony-forming units;Combined Modality Therapy;Data;design;Disease;Effectiveness;Epithelium;experimental study;Frequencies;Gastric ulcer;Gene Proteins;Genetic Transcription;Gland;Green Fluorescent Proteins;Growth;Growth Inhibitors;Health;Helicobacter Infections;Helicobacter pylori;Human;improved;in vivo;Incidence;Individual;Infection;inhibitor;innovation;insight;Knowledge;malignant stomach neoplasm;Measurement;Measures;Metabolism;metabolome;Microbe;Mission;Molecular Biology;mouse model;Mus;mutant;Mycobacterium tuberculosis;Nature;Neisseria;Nutrient;Organism;Outcome;pathogen;pathogenic bacteria;Persons;Physiology;Population;Population Sizes;Production;Proteins;Proton Pump Inhibitors;Public Health;Publishing;Pump;Refractory;Research;Ribosomal Proteins;Ribosomes;Rodent Model;Scheme;Signal Transduction;Solid;Source;Stomach;synergism;Testing;Therapeutic;therapy development;Time;Translational Repression;Translations;Treatment Effectiveness;Ulcer;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding and manipulating chronic Helicobacter pylori to enhance treatment


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HOUSTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative Sickle cell disease (SCD) is a genetic disease that affects millions of people worldwide, causing frequent pain episodes, stroke, organ damage and a median life expectancy in the mid-forties. We propose to determine the detrimental and potentially beneficial effects of unintended large gene modifications due to Cas9-cutting, and develop ways to reduce large deletions, with the goal of increasing the efficacy and safety of genome editing based treatment of SCD.

PI_NAMEs: BAO, GANG  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Adoption;Affect;Alleles;Allogenic;American;Autologous;base;base editing;beta Globin;Biological;Blood specimen;Blood Transfusion;Bone Marrow;Cell Separation;Cells;Chronic;Chronic Disease;Clinical;clinical practice;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR therapeutics;CRISPR/Cas technology;curative treatments;Data;design;Development;DNA Repair;Engraftment;Enhancers;Erythroid;Erythroid Cells;Erythropoiesis;Evaluation;Fetal Hemoglobin;Frequencies;Gene Modified;gene-editing approach;Genes;Genetic Diseases;genome editing;Genotype;Goals;graft vs host disease;Guide RNA;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;Immunodeficient Mouse;improved;insertion/deletion mutation;Life Expectancy;Lymphoid;Methods;Morbidity - disease rate;mortality;Mus;Mutation;Myelogenous;novel strategies;Oligonucleotides;Organ;Outcome;Pain;palliative;Pathway interactions;Patients;peripheral blood;Persons;pharmacologic;Pharmacologic Substance;Phase I Clinical Trials;Phenotype;prevent;Reporting;Research;RNA analysis;Safety;Sickle Cell Anemia;sickling;single molecule real time sequencing;single-cell RNA sequencing;Site;Stroke;Testing;therapeutic genome editing;Time;transcriptomics;Translations;treatment strategy

PROJECT_TITLE: Deciphering unintended large gene modifications in gene editing for sickle cell disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Neurosciences;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PATHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is significant because newly developed mouse models of Lyme neuroborrelisois (LNB) will be developed upon competition of this project. As a result, the model will be the basis for development of new therapeutics and diagnostic tools for LNB patients. Thus, the proposed work is relevant to the NIH’s mission.

PI_NAMEs: ROGOVSKY, ARTEM S (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affect;Animal Model;Animals;antimicrobial;Arthritis;behavioral study;Borrelia burgdorferi;Borrelia garinii;Borrelia mayonii;Brain;brain parenchyma;Carditis;Cells;Central Nervous System;Chronic;chronic infection;Clinical;Communities;Complex;Control Locus;cost;cytokine;Data;Development;diagnostic tool;Disease;Dura Mater;Encephalitis;Ethics;Exhibits;Facial nerve structure;Fatigue;flu;Foundations;Funding;Future;Genetic;Genetic Recombination;Genetic Variation;Goals;Headache;Human;Inbred C3H Mice;Infection;Inflammation;Inflammatory;innovation;insight;Interferons;Invaded;Investigation;Knowledge;Laboratory mice;Learning Disabilities;Left;Lesion;Leucocytic infiltrate;Limb structure;Lyme Disease;Lyme disease diagnosis;Lyme Neuroborreliosis;lyme pathogenesis;Maps;Memory Loss;Meningitis;Mental Depression;Mission;Modeling;mouse development;mouse model;Mouse Strains;Mus;Muscle Weakness;Nerve;neural;Neurocognitive;neuroinflammation;Neurologic;Neurologic Signs;Neurologic Symptoms;nonhuman primate;novel diagnostics;novel therapeutics;Order Spirochaetales;Pain;Paralysed;pathogen;Pathogenesis;Pathogenicity;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;permissiveness;Phenotype;Predisposition;Process;Quantitative Trait Loci;Reagent;Research;Resolution;Resource Development;Resources;response;Sensory;skin lesion;Spinal Cord;Symptoms;Testing;Tick-Borne Diseases;Tissues;tool;Treatment Protocols;Trigeminal System;United States National Institutes of Health;Up-Regulation;Vaccines;Work

PROJECT_TITLE: Exploring the Collaborative Cross resource to identify different phenotypes of Lyme neuroborreliosis and disease-contributing genetic factors


ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

ORG_STATE: MA

PHR: PROJECT NARRATIVE The University of Massachusetts, Boston (UMass Boston) and Dana-Farber/Harvard Cancer Center (DF/HCC) Partnership is committed to further developing a shared rigorous and collaborative transdisciplinary cancer and disparities-related research program that is primed for “Bridging the Divides: Innovations to Address Gaps in Cancer Disparities Research, Education, Outreach and Infrastructure.” Sophisticated research projects are proposed across several areas of basic biomedical and population sciences that will employ evidence and methods to converge upon and impact cancer and cancer health disparities at multiple levels of analysis. These projects, together with state-of-the-art Outreach and Research Education Cores and creative Research Design and Analysis Core and Genomics Cores, will serve to build research capacity and infrastructure at UMass Boston, expand the cancer disparities platform and community outreach programs at DF/HCC; and make, at an elevated level, significant advances to the science of cancer control.

PI_NAMEs: COLON-CARMONA, ADAN  (contact);MACOSKA, JILL A.

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Absenteeism;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;Biology;Boston;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;Cancer Science;career;career development;Charge;Color;Communities;community engagement;Community Networks;community organizations;Community Outreach;Creativeness;Data;Data Set;Dedications;Discipline;Disparity;dissemination science;Education;education research;Ethnic Origin;experience;Experimental Designs;experimental study;Faculty;Foundations;Funding;Genomics;Goals;Government;Grant;Health Disparities Research;implementation science;Incidence;Infrastructure;innovation;Institution;Joints;Lasers;Leadership;Malignant Neoplasms;Massachusetts;member;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;outreach;outreach program;Phase;Population;Population Group;Population Heterogeneity;Population Sciences;Postdoctoral Fellow;programs;Race;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research study;Resource Sharing;Resources;Science;socioeconomic disparity;Solid;Source;Students;Training;translational model;translational potential;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 1/2 The University of Massachusetts, Boston - Dana-Farber/Harvard Cancer Center U54 Comprehensive Partnership for Cancer Disparities Research


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Hypertension

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE We plan to define how the sequences of specialized nucleic acid molecules (so-called ribonucleic acid or RNA) in the cells of blood vessels of the lungs are dynamically altered to control a mysterious disease called pulmonary hypertension (PH). If successful, the results of this work will advance our understanding of how PH develops and will provide a substantial basis to generate more effective tests to detect and treat this deadly disease.

PI_NAMEs: WOODCOCK, CHEN-SHAN JULIA (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;Adenosine;Affect;Apoptosis;Apoptotic;Binding;Biological Assay;Biology;Blood;Blood Vessels;career;career development;cell injury;Cell Physiology;Cell Survival;cell type;Cells;Cessation of life;circadian;Clinical;Code;Complex;CRISPR/Cas technology;Data;Dependovirus;Development;Diagnostic;Disease;Double-Stranded RNA;dsRNA adenosine deaminase;Elements;Endothelial Cells;Endothelium;Ensure;Enzymes;Event;experimental study;Failure;Foundations;Functional disorder;Gene Expression Regulation;Genes;Genome;Health;heart function;hemodynamics;Homeostasis;Hypoxia;hypoxia-induced pulmonary hypertension;IL6 gene;Immunity;Immunoprecipitation;In Vitro;in vivo;inhibitor;Inosine;Interdisciplinary Study;Interferons;knock-down;Knock-out;Knockout Mice;Knowledge;Lung;Medial;Mediating;Mentorship;Messenger RNA;Molecular;Molecular Target;mRNA Decay;mRNA Expression;mRNA Stability;Mus;mutant;Natural Immunity;nocturnin;novel;novel strategies;Nucleic Acids;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;PECAM1 gene;Peripheral;pharmacologic;Physiology;Pilot Projects;Play;Post-Transcriptional Regulation;posttranscriptional;Production;programs;Proteins;pulmonary arterial pressure;pulmonary artery endothelial cell;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Regulation;repaired;Research;Research Personnel;response;right ventricular failure;Right Ventricular Hypertrophy;RNA;RNA Editing;RNA Sequences;RNA-Binding Proteins;Role;Scientist;Serum;Signal Transduction;single-cell RNA sequencing;Site;Small Interfering RNA;Structure;Structure of parenchyma of lung;Systolic Pressure;Testing;Therapeutic;therapeutically effective;Thick;Training;Transcript;transcription factor;transcriptome sequencing;Transgenic Mice;Untranslated RNA;Vascular remodeling;Ventricular;Work

PROJECT_TITLE: RNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertension

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Enterovirus D68 (EV-D68) has been implicated in severe respiratory illness and acute flaccid myelitis (AFM), a polio-like illness causing paralysis in previously healthy children. There are no specific treatments for AFM, most children are left with residual deficits, and it is currently unknown how EV-D68 targets the central nervous system. The goal of this proposal is to identify how EV-D68 mediates cellular damage in the human spinal cord by using an innovative human spinal cord organoid model.

PI_NAMEs: FREEMAN, MEGAN CULLER (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 3-Dimensional;Achievement;Acids;acute flaccid myelitis;Advisory Committees;Antibodies;Basic Science;Biological Assay;Biological Models;bronchial epithelium;career development;cell injury;Cell Line;Cell Lineage;Cell model;cell type;Cells;Cellular biology;Cellular Tropism;Central Nervous System;Central Nervous System Infections;Cerebrospinal Fluid;Cessation of life;Child;Childhood;Circulation;clinical training;Collaborations;Communicable Diseases;Coronavirus Infections;Coxsackie Viruses;CSF3 gene;cytokine;Cytolysis;Data;Disease;disease phenotype;Doctor of Philosophy;Echo Viruses;Encephalitis;Enterovirus;Enterovirus 68;Enterovirus 71;Enterovirus Infections;Environment;Epithelial Cells;Epithelium;excitotoxicity;experience;experimental study;Family;Foundations;Funding;Genes;Genetic Drift;Genetic Variation;Glutamate Transporter;Glutamates;Goals;HIV;Human;human model;human tissue;Imaging Techniques;Immune;Immune response;Immunity;Immunologics;Immunology;Induced Neurons;Infection;Inflammatory Response;Injury;Innate Immune Response;innovation;Interferons;Intestines;Intramuscular Injections;Investigation;Kinetics;Knowledge;Left;Location;Mammals;Measles;Mediating;Medical center;medical schools;member;Mentors;Mentorship;Modeling;Motor Neurons;multidisciplinary;Mus;National Institute of Allergy and Infectious Disease;Natural Immunity;neonatal mice;Nervous System;Neurodegenerative Disorders;neuromechanism;Neuronal Injury;Neurons;Neurosciences;Neurotransmitters;novel;novel virus;oral communication;Organoids;Paralysed;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;pediatrician scientist;Pediatrics;Physicians;Physiological;Poliomyelitis;prevent;programs;Research;Residual state;Resources;respiratory;Respiratory System;respiratory virus;response;responsible research conduct;RNA;Route;Sampling;Scientist;Site;skills;Specificity;Spinal;Spinal Cord;Stomach;symposium;Syndrome;Technical Expertise;Techniques;Temperature;therapeutic target;timeline;Tissue imaging;Tissue Model;Tissues;Training;Transcript;Universities;Viral;Viral Pathogenesis;Virus;Virus Diseases;Virus Replication;Work;Writing

PROJECT_TITLE: Investigation of enterovirus D68 pathogenesis in the human spinal cord

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project Narrative Aortopathy including aneurysms, dissection, and rupture are life-threatening diseases that have no validated medications. The only therapeutic option is watchful waiting prior to major surgical intervention. This project will provide novel mechanistic insight into these diseases that will enable more focused efforts in understanding the disease pathogenesis and developing medical treatment.

PI_NAMEs: DAUGHERTY, ALAN  (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TITLE: Determinants of Aorta Heterogeneity


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Malaria is a serious and often fatal infectious disease, posing an enormous global health challenge with over 250 million cases per year and more than 600,000 deaths in year 2020. Our goal is to develop small chemical molecules that trick malaria parasites into producing multiple versions of an inhibitor of one of their own essential enzyme complexes, consequently overcoming resistance. Successful completion of the proposed studies will provide novel anti- malarial therapeutics.

PI_NAMEs: LIN, GANG  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Active Sites;Africa;African;analog;Anti-malarials;Artemisinins;Binding;Binding Proteins;Biochemical;Biological;Biological Assay;Biological Availability;Cells;Cessation of life;Chemicals;Child;Clinical;Combined Modality Therapy;Communicable Diseases;cytotoxicity;detection limit;Distal;Drug Combinations;Drug Kinetics;Drug resistance;efficacy study;efficacy testing;Exposure to;Frequencies;global health;Goals;Hemin;high risk;HIV;humanized mouse;Hybrids;improved;In Vitro;in vivo;Infection;inhibitor;Investigation;lead optimization;Life Cycle Stages;Lipids;Malaria;Malignant Neoplasms;Modeling;mouse model;multicatalytic endopeptidase complex;multidrug tolerance;Multienzyme Complexes;Mus;mutant;Mutation;novel;Oligopeptides;Oral;Organism;oxidative damage;Parasite resistance;Parasites;Penetration;Peptides;Pharmaceutical Preparations;pharmacophore;Plasmodium;Plasmodium falciparum;Point Mutation;prevent;Prevention;Process;Prodrugs;Property;Proteasome Inhibitor;Proteins;Recrudescences;Reporting;Resistance;Resistance development;resistance mechanism;resistance mutation;Site;Southeastern Asia;standard care;Structure-Activity Relationship;success;synergism;System;Testing;Therapeutic;Time;Tissues;Toxic effect;tuberculosis treatment;Ubiquitin;Vertebral column

PROJECT_TITLE: Hijacking Plasmodium ubiquitin-proteasome system to defeat drug resistance

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Diabetes;Digestive Diseases;Genetics;Human Genome;Microbiome;Pancreatic Cancer;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE BCM is a clinical center in the CPDPC-2. We are requesting supplemental funds to our grant award 2 U01 DK108326-10 to cover the clinical care costs associated with recruiting, enrolling, and following participants according to the PROCEED Study, PROCEED Substudies, and DETECT Study protocols. BCM will also use the supplemental funds to recruit patients, procure specimens prospectively, collect epidemiological and clinical data, and contribute to the completion of any new studies approved by the Steering Committee during the CPDPC-2.

PI_NAMEs: FISHER, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Award;care costs;chronic pancreatitis;clinical care;clinical center;Clinical Data;college;Diabetes Mellitus;Diagnosis;dysbiosis;Enrollment;epidemiologic data;epidemiology study;Evaluation;Funding;Grant;Malignant neoplasm of pancreas;Medicine;microbiome;Pancreatitis;Participant;Patient Recruitments;prospective;Protocols documentation;recruit;Secondary to;Specimen;Testing;translational study

PROJECT_TITLE: DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCER


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROGRAM NARRATIVE Achieving long-term survival of organ transplants without the need for lifelong immunosuppression will provide transplant recipients with healthier and longer lives. These studies will explore ways to eliminate the need for chronic immunosuppressive drugs in patients undergoing lung transplantation.

PI_NAMEs: MADSEN, JOREN C (contact)

PROGRAM_OFFICER_NAME: SHAW, JULIA M

PROJECT_TERMS: Acute;Address;Allograft Tolerance;Allografting;Antibodies;Autoimmune Diseases;BCL2 gene;Biological;Biological Assay;Bone Marrow Diseases;Bone Marrow Transplantation;career;Cell Therapy;Chimerism;Chronic;Clinical;clinical application;clinical translation;clinical trial readiness;Collaborations;Computer Analysis;conditioning;Cytomegalovirus Infections;Dedications;Engineering;Environment;experimental study;FDA approved;Fertilization;Flow Cytometry;Funding;Gene Modified;Goals;Hematopoietic;Human;Immune system;Immunity;Immunogenetics;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;innovation;insight;kidney allograft;Life;Lung;lung allograft;lung basal segment;Lung Transplantation;Lymphoproliferative Disorders;Molecular Immunology;Monoclonal Antibodies;Myelosuppression;nanoparticle;nanotherapy;next generation;nonhuman primate;novel strategies;Organ;Organ Survival;Organ Transplantation;Patients;Pharmaceutical Preparations;Physicians;Play;post-transplant;Preparation;Procedures;programs;Protocols documentation;Radiation;Regulation;Regulatory T-Lymphocyte;Research Personnel;Resistance;Risk Reduction;Sampling;Solid;statistics;Stress;Sum;synergism;Testing;Time;Toxic effect;Training;transcriptomics;Transplant Recipients;Transplant Surgeon;Transplant-Related Disorder;Transplantation;Transplantation Tolerance;virology;Whole-Body Irradiation

PROJECT_TITLE: Novel Approaches to Inducing Lung Allograft Tolerance in NHPs


PROJECT_TERMS: Allograft Tolerance;cooperative study;Ensure;Expenditure;Funding;Funding Opportunities;Infrastructure;lung allograft;Monitor;National Institute of Allergy and Infectious Disease;nonhuman primate;novel strategies;Procedures;programs;Reporting;Structure;Transplantation Tolerance;web site

PROJECT_TITLE: Infrastructure and Opportunities Fund Management Core


ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Although cancer is a leading cause of mortality among people with HIV (PWH) in the US, data to inform tailored strategies to reduce preventable cancer-related deaths using recommended screening modalities are lacking. Through this proposal, we aim to address this gap in scientific knowledge, leveraging the All of Us data resource a national cohort including survey and a novel electronic health record-based linkage of multiple health systems throughout the US to gain real world insights into (1) patterns and trends in cancer screening uptake, follow-up, and outcomes among PWH compared to those without HIV and (2) social inequities (social determinants of health) in screening behaviors among PWH to identify actionable targets for intervention. Our results will elucidate mechanisms that could lead to the development of future interventions to: 1) improve coverage of cancer screening among PWH, 2) address barriers to cancer screening access and follow-up among PWH, and 3) optimize screening guidelines for PWH.

PI_NAMEs: ISLAM, JESSICA YASMINE;WRIGHT, KENNETH LYNN (contact)

PROJECT_TERMS: access disparities;Address;Adherence;Adult;Age;age group;age stratification;Aging;All of Us Research Program;Area;Behavior;Biological Factors;Breast;Breast Cancer Detection;Calendar;Cancer Detection;cancer diagnosis;Cancer Prevention Intervention;Caring;Cessation of life;Characteristics;Clinic Visits;Clinical;Code;cohort;Colorectal;Colorectal Cancer;colorectal cancer screening;comorbidity;Complex;Crime;Current Procedural Terminology Codes;Data;data resource;Data Sources;demographics;Development;Diagnosis;Disease;Distant;economic disparity;Economics;Electronic Health Record;Ethnic Origin;Ethnic Population;Evaluation;experience;Face;Federally Qualified Health Center;Female breast;follow-up;Future;General Population;Goals;Guideline Adherence;Guidelines;Health;Health system;Healthcare;HIV;HIV diagnosis;HIV Seronegativity;Immunocompetent;improved;Individual;Inequity;Infrastructure;insight;Insurance Coverage;International Classification of Disease Codes;Intervention;Knowledge;Link;Lung;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Medical;Modality;Morbidity - disease rate;mortality;Neighborhoods;novel;Outcome;Patient Recruitments;Patient Self-Report;Patients;Pattern;perceived discrimination;perceived stress;Persons;Population;Prevalence;Prevention;Procedures;Qualifying;Quality of life;Race;racial population;Recording of previous events;recruit;Research;Resources;Risk Factors;Sample Size;Sampling;screening;Screening for cancer;screening guidelines;Screening procedure;Screening Result;sex;SNOMED Clinical Terms;social;social factors;social health determinants;socioeconomics;study population;Surveys;Survival Rate;therapy development;Time;time interval;Time trend;Translating;trend;tv watching;United States Preventative Services Task Force;uptake;Visit;Vulnerable Populations;walkability;Work

PROJECT_TITLE: Cancer screening behaviors among people with and without HIV in All of Us


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Nutrition;Patient Safety;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Minoritized children are at risk for severe early childhood caries, which are often treated with dental surgery under general anesthesia (DGA). DGA does not address underlying oral health behaviors that can prevent future disease recurrence, and no research to date has developed a multi-behavioral parenting intervention for this population. The current study aims to develop and test the initial efficacy of PROTECT (Preventing Recurrent Operations Targeting Early Childhood Caries Treatment), a 6-month, community health worker-delivered, behavioral parenting intervention for a minoritized, preschool-aged, pediatric dental surgical population targeting tooth brushing frequency and consumption of added sugars.

PI_NAMEs: BUSCEMI, JOANNA ;LEE, HELEN H (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Anesthesiology;Bacteria;Behavior;behavior change;behavior influence;Behavior Therapy;Behavioral;burden of illness;Calories;Caregivers;catalyst;Child;Child Behavior;Child Health;Child Rearing;Childhood;Chronic Disease;Clinical;clinical development;Community Health Aides;Consumption;Data;Dental;Dental caries;dental surgery;Dentistry;Development;Diet;Dietary Intervention;Disease;disorder risk;Dissemination and Implementation;Dose;early childhood;Effectiveness of Interventions;efficacy testing;Enrollment;ethnic minority population;Etiology;Event;evidence base;experience;Family;feasibility testing;follow-up;Frequencies;Future;General Anesthesia;Goals;Health behavior;Health behavior change;health knowledge;Health Status;high risk;Household;Iatrogenesis;improved;Inequity;Intake;Intervention;intervention delivery;Knowledge;Life;Link;longitudinal analysis;Low income;lower income families;Measurement;Measures;Mediation;Mediator;Medicaid;Mental Health;Minority;minority children;Modeling;Monitor;Motivation;Nursery Schools;nutrition;Nutritional Science;obesity in children;operation;Operative Surgical Procedures;Oral health;oral microbiome;Outcome;parenting intervention;Parents;Participant;Pathway interactions;Pediatrics;Perioperative;Persons;Phase;Pilot Projects;Population;Population Intervention;Preschool Child;Prevalence;prevent;Preventive dental care;primary outcome;Protocols documentation;Provider;Psychology;psychosocial;psychosocial wellbeing;Qualitative Research;Quality of life;racial minority population;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Recurrence;Recurrent disease;remote assessment;Reporting;Research;Research Personnel;Ribosomal RNA;Risk;Role;rural area;rural dwellers;Safety;saliva sample;Schedule;School-Age Population;secondary outcome;Self Efficacy;social;social cognitive theory;stressor;sugar;Target Populations;Telephone;Testing;Text Messaging;Time;Toothbrushing;Training;treatment as usual;treatment comparison;treatment group;Work

PROJECT_TITLE: Testing a Multi-behavioral Intervention to Improve Oral Health Behaviors in the Pediatric Dental Surgery Population


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Services;Patient Safety;Pediatric;Prevention;Primary Health Care

ORG_CITY: GAINESVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative This research seeks to promote best practices in interactions among dental healthcare professionals, parents/caregivers, and young children ages 0 through 5, and so has broad public health relevance for all children in this age group. Building upon research on usual care in dental practices to understand skills currently being used with children, the present research will develop and test mechanisms of change involved in a workshop for dental providers on evidence-informed interactional skills. Currently, evidence-based, specialized training for dental providers to achieve a positive, acceptable, and comfortable dental experience for young children is unavailable; providers having such skills may significantly benefit the quality of care families of young children receive in oral healthcare settings.

PI_NAMEs: MCNEIL, CHERYL BODIFORD;MCNEIL, DANIEL W (contact)

PROGRAM_OFFICER_NAME: ELWOOD, WILLIAM N

PROJECT_TERMS: 6 year old;Academy;acceptability and feasibility;Adherence;Adoption;Adult Children;Affect;Age;age group;Age Months;American;Anxiety;Appointment;Arkansas;Behavior;Behavior Control;Behavioral;Caregivers;Caring;Child;Child Behavior;Child Welfare;Childhood;Climate;Clinic;Clinical Protocols;Clinical Trials;Code;Communities;community partners;Complex;Conscious Sedation;curriculum development;Data;data management;data quality;Dental;Dental Assistants;Dental Care;Dental caries;Dental Education;Dental General Practice;Dental Offices;Dental Staff;Dentistry;Dentists;design;Development;Discipline;Distress;early childhood;Educational Intervention;Educational process of instructing;Educational workshop;Effectiveness;Enrollment;Evaluation;evidence base;experience;Family;follow-up;Foundations;Fright;Funding;Future;General Anesthesia;Goals;Good Clinical Practice;health care settings;Health Personnel;Health Professional;Healthcare;Human Resources;implementation design;implementation outcomes;improved;Injections;innovation;Institutional Review Boards;Instruction;instrument;International;Intervention;Knowledge;Label;Learning;Life;Manuals;Measures;Medical;medical specialties;Methods;Nitrous Oxide;North Carolina;Oral cavity;Oral health;Outcome;Outcome Measure;Pain;Parent-Child Relations;Parents;Patients;Pediatric Dentistry;pediatric patients;Perception;pharmacologic;Phase;Procedures;programs;Protocols documentation;Provider;provider adoption;provider behavior;psychologic;public health relevance;Quality Control;Quality of Care;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Residencies;Risk;Role;satisfaction;Site;skill acquisition;skills;skills training;Students;Support System;symposium;System;Testing;Time;Tooth structure;Training;Training Programs;treatment as usual;Universities;Videotape;Visit;West Virginia

PROJECT_TITLE: Implementing Evidence-based Behavioral Skills in Pediatric Oral Healthcare Providers


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE In metazoans, gene expression is controlled in a tissue- and cell-type specific manner through regulatory sequence elements in the genome. Elements that suppress gene expression, termed transcriptional silencers, are not well understood. The goals of this project, using Drosophila embryonic mesoderm as a model system, are to quantify the activities of large sets of tissue-/cell-type specific silencers, elucidate their chromatin signatures, and reveal the DNA sequence motifs, repressive proteins and chromosomal interactions through which silencers exert their regulatory effects.

PI_NAMEs: BULYK, MARTHA L (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adult;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Models;cell type;Cells;ChIP-on-chip;ChIP-seq;Chromatin;Chromatin Modeling;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;computer studies;Data;Data Analyses;Development;DNA;DNA Binding;DNA Sequence;Drosophila genus;Drosophila melanogaster;Elements;Embryo;Enhancers;Exhibits;experimental study;Gene Expression;Gene Expression Profile;gene repression;Genes;genetic corepressor;Genetic Transcription;Genome;Genomics;Goals;Hi-C;histone modification;Human;in vivo;knock-down;Knock-out;Mass Spectrum Analysis;Mediating;Mesoderm;Mutate;Nature;new technology;novel;Post-Translational Protein Processing;promoter;Proteins;Regulatory Element;Repressor Proteins;response;RNA Interference;Role;Snails;Specific qualifier value;Specificity;Stimulus;Stretching;Surveys;Technology;Testing;Tissues;transcription factor;Untranslated RNA;Validation

PROJECT_TITLE: Transcriptional silencers in Drosophila

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Social Determinants of Health;Women's Health Research

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Exposure of pregnant women to environmental pollution and toxicants significantly increase risks to mother’s health after birth. Using already collected samples, our study will use innovative technologies and will identify the drivers of immune dysfunction and potential modifiable factors. We will determine how these immune findings are associated with pollution exposure and outcomes of disease.

PI_NAMEs: NADEAU, KARI C. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: absorption;adverse outcome;Affect;Age;Air Pollution;ambient air pollution;Area;Asthma;ATAC-seq;Autoimmune Diseases;Automobile Driving;Bioinformatics;Birth;Blood;Blood specimen;Cardiovascular Diseases;Cells;ChIP-seq;Chronic;Clinical;cohort;Data;Data Set;Discipline of obstetrics;Disease;Disease Outcome;Eclampsia;Environmental Pollution;epidemiology study;Epigenetic Process;Experimental Designs;Exposure to;Female;Fetus;fine particles;Functional disorder;Funding;Future;Gene Expression;Growth;health of the mother;healthy pregnancy;high dimensionality;high risk;Histones;Hypersensitivity;IL27RA gene;Immune;immune health;Immune response;Immune system;Immune System Diseases;Immune Tolerance;Immunologics;Immunology;Immunosuppression;Individual;Infection;Infertility;innovative technologies;Knowledge;Link;Long-Term Effects;Lung;Malignant Neoplasms;Maps;Mass Spectrum Analysis;maternal immune system;maternal morbidity;Maternal Mortality;Measures;Metadata;Methods;Methylation;Modification;Molecular;Mothers;National Institute of Environmental Health Sciences;Outcome;parous;Particulate Matter;phenotypic biomarker;Plasma;Play;pollutant;Pollution;post pregnancy;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Trimesters;pregnant;Pregnant Women;Premature Birth;Proliferating;Proteomics;Public Health;Public Policy;Publishing;Regulatory T-Lymphocyte;Research;Research Project Grants;response;Risk;Role;Sampling;Second Pregnancy Trimester;Stream;System;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Testing;Time;tool;Toxic Environmental Substances;toxicant;Toxicant exposure;Vulnerable Populations;Woman;Women's Health

PROJECT_TITLE: Immune Tolerance Dysfunction in Pregnancy due to Ambient Air Pollution Exposure


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Infectious Diseases;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE I propose a biologically motivated, mathematical modeling approach to understand how neuroimaging and other biomarkers can be used to better understand Alzheimer’s disease biology. I plan to fit mechanistic models to data from 3 cohorts across the age span of Alzheimer’s disease onset: Longitudinal Early Onset Alzheimer’s Disease Study (LEADS) (ages 40-64), Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort (ages 55-90), and The 90+ Study (ages 90+). The long-term objective of this research is to improve our understanding of the age-specific pathophysiology of Alzheimer’s disease, determining the precise relationship between tau and cognition, with the ultimate goal of guiding therapeutic development and trials for Alzheimer’s treatment.

PI_NAMEs: ACKLEY, SARAH  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;Age;age difference;age related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Amyloid;Atrophic;Biological;Biological Markers;Biology;Blood Vessels;blood-based biomarker;Brain;California;Clinical;Cognition;cognitive change;cohort;college;Communicable Diseases;Complex;Computational Biology;computerized tools;Data;Drug Targeting;Early Onset Alzheimer Disease;experience;Functional disorder;Goals;Guidelines;hands on research;Heterogeneity;Impaired cognition;improved;Individual;Infectious Disease Epidemiology;Intervention;Knowledge;Late Onset Alzheimer Disease;Lead;life span;Light;Link;Location;London;Magnetic Resonance Imaging;mathematical model;Mathematics;Measurement;Measures;Mentors;Mentorship;Modeling;multimodality;Neurofibrillary Tangles;neurofilament;neuroimaging;Neuropsychology;Onset of illness;Outcome;Pathologic Processes;Pathology;Physiological;Positron-Emission Tomography;professor;Research;Research Activity;Structure;System;targeted treatment;tau aggregation;tau Proteins;Techniques;therapeutic development;Therapeutic Trials;Time;Training;Training Activity;treatment duration;trial design;Universities;White Matter Hyperintensity

PROJECT_TITLE: Mathematical Models of Tau-PET Measures and Cognitive Decline in Alzheimer's Disease Across the Lifespan


NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Desmosomes are critically important in resisting mechanical stress, impacting tissue morphogenesis and human health, but much is unknown about its role in the mechanics and mechanotransduction at the epithelial cell-cell junction. Through this program, we will examine the desmosome’s ability to maintain the mechanical integrity of the junction and determine its potential to transduce mechanical cues at the junction in coordination with molecules at the adherens junctions and the actin network. The understanding will aid in developing treatments for disorders resulting from interference with this adhesive junction.

PI_NAMEs: YANG, RUIGUO  (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Adherens Junction;Adhesives;Affect;Area;cell behavior;cell motility;Cell Separation;Cell-Cell Adhesion;Cells;Chemicals;Complex;Critical Pathways;Desmosomes;Development;Disease;Elements;Epithelial Cells;Epithelium;gain of function mutation;Genetic Transcription;Health;Heart;Human;Intercellular Junctions;Intermediate Filaments;Knowledge;loss of function;mechanical load;mechanical signal;Mechanical Stress;Mechanics;mechanotransduction;Mediating;migration;Molecular;Morphogenesis;Pathway interactions;Play;programs;Proteins;Regulation;Research;response;Role;Series;Signal Pathway;Signal Transduction;Site;Skin;Stress;Tissues;Weight-Bearing state;wound healing

PROJECT_TITLE: Direct and Quantitative Probing of Desmosome Mechanotransduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The indirect impacts of disasters—morbidity and mortality due to compromised conditions such as food security and clean water—are typically not included in estimates of disaster deaths. Child health is particularly sensitive to such compromised conditions and understanding the indirect burden of disasters on child health is central for designing mitigation and adaptation strategies. This project aims to estimate the indirect child mortality burden from floods and severe storms around the world.

PI_NAMEs: WAGNER, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Affect;Africa;antenatal;Area;Asia;Behavior;Birth;Birth Weight;Catalogs;Cells;Cessation of life;Child;Child Health;Child Mortality;Classification;climate change;climate disaster;climate impact;Conflict (Psychology);contaminated water;Country;Data;Data Analyses;Data Set;Data Sources;Databases;Demographic and Health Surveys;design;Disasters;econometrics;Epidemiology;Event;Exposure to;extreme storms;extreme weather;fighting;Floods;Food Contamination;food insecurity;food security;Foundations;Frequencies;Geography;global health;Goals;Health;health data;health record;health service use;Health system;high risk;Human;Hurricane;Imagery;improved;Income;Infant;Infant Mortality;Infrastructure;insight;Latin America;Life;Link;Location;low and middle-income countries;Malnutrition;Measurement;Measures;Methods;Morbidity - disease rate;mortality;Natural Disasters;neglect;Outcome;Policies;population survey;Postnatal Care;programs;Puerto Rico;Qualifying;remote sensing;Research Personnel;resilience;Resources;Risk;Risk Reduction;Sanitation;Services;Shock;Testing;Vaccination;Visit;Water;Work

PROJECT_TITLE: The Impact of Natural Disasters on Child Health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE: OVERALL The well-established Meharry Medical College/Vanderbilt-Ingram Cancer Center/Tennessee State University Cancer Partnership (MVTCP) triad provides an exceptional environment to identify and address health care inequities in cancer seen in underrepresented minorities. The proposed research projects, cores, and shared resource cores will grow research and propose evidence-based solutions address to these inequities. Further, the development of expanded research infrastructure at MMC and TSU, enhancement of minority education programs, and improvement to the effectiveness of cancer-related activities will address health care disparities in the greater Nashville geographical region, with the ultimate goal of contributing to reducing health disparities among cancer patients in minority and underserved communities.

PI_NAMEs: PAL, TUYA  (contact);WINKFIELD, KAREN MARIE

PROJECT_TERMS: Address;African ancestry;anti-cancer research;Area;Award;Awareness;Basic Science;Behavioral;Big Data;Bioinformatics;Bioinformatics Shared Resource;Biological Factors;Biometry;Breast Cancer Treatment;Cancer Center;cancer clinical trial;cancer health disparity;cancer initiation;Cancer Patient;Cancer Research Project;career;CDK4 gene;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;collaborative approach;Colorectal Cancer;Communities;Community Health;community organizations;community research;Comprehensive Cancer Center;Death Rate;Development;Discipline;Disparity;Education;education research;Effectiveness;Electronic Health Record;Environment;Equity;Ethnic Origin;European ancestry;Evaluation;evidence base;Extramural Activities;Faculty;Financial Hardship;Fostering;Geographic Locations;Geography;Goals;graduate student;Granulocyte Colony-Stimulating Factor;Growth;health care disparity;Health Educators;high school;Immunooncology;improved;Incidence;Individual;Inequity;Infrastructure;inhibitor;Institution;Intervention Trial;Lead;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Medical Students;Minority;minority communities;Minority-Serving Institution;Mission;mortality;multidisciplinary;Oncology;Outcome;outcome disparities;outreach;outreach program;Pathology;Pathway interactions;Patient Participation;Peer Review;Population Research;Population Sciences;Prevalence;programs;Publications;Race;recruit;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resource Sharing;screening;Series;socioeconomics;survivorship;Tennessee;Training;Translational Research;treatment trial;undergraduate student;Underrepresented Minority;underserved community;United States;Universities

PROJECT_TITLE: Disparities in breast cancer treatment using Granulocyte colony-stimulating factors and CDK4/6 inhibitors between African and European ancestry individuals in two large Electronic Health Records


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE – PROJECT 1 Approximately 15-25 million people worldwide are infected with HTLV-1 with a small percentage developing adult  T-cell leukemia. The cancer is aggressive and there is currently no effective treatment. This project focuses on  a novel viral gene encoded by the antisense strand of the HTLV-1 genome, termed hbz, and the proposed studies will provide a significant advance in our basic knowledge of the role of hbz in transformation and disease  and will have significant implications for therapeutic targeting.

PI_NAMEs: GREEN, PATRICK LEE (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Adult Precursor T Lymphoblastic Leukemia;Adult T-Cell Leukemia/Lymphoma;Animal Model;Animals;Attenuated;Binding;Binding Proteins;Biological Assay;Bone Diseases;Cancer Model;Cell Proliferation;Cell Survival;Cells;Cellular biology;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Data;design;Disease;Disease Progression;DNA Double Strand Break;effective therapy;experimental study;Foundations;Funding;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Human T-lymphotropic virus 1;Human T-lymphotropic virus 2;In Vitro;in vivo;Individual;Infection;insight;IRF1 gene;Knock-out;Knowledge;leukemia/lymphoma;leukemogenesis;Malignant - descriptor;Malignant Neoplasms;Mediating;Messenger RNA;metaplastic cell transformation;Modeling;Nervous System Disorder;Nitric Oxide Synthase;novel;Oncoproteins;Oryctolagus cuniculus;Osteolytic;Outcome;p65;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Play;prevent;Process;protein expression;Protein Interaction Mapping;Proteins;Proteomics;Repression;Retroviridae;RNA;Role;senescence;Signal Pathway;Signal Transduction;Structure;tax Genes;Taxes;therapeutic target;TOP1 gene;Transactivation;Transforming Growth Factor beta;Transgenic Mice;Translating;tumor;ubiquitin-protein ligase;vector;Viral;Viral Genes;Viral Vector;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Project 1: Role of HTLV-1 Hbz in Transformation and Disease


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Exposure to interpersonal violence (IPV) is associated with long-term negative mental health consequences, including an increased risk for posttraumatic stress disorder (PTSD), especially in women. Our previous studies examining the impact and timing of IPV experienced during specific developmental windows revealed increased psychophysiological reactivity and a unique EV protein signature belonging to a 17q21 gene cluster and associated with skin keratinocytes, specific to Merkel cells and only found when IPV was experienced between 14-18 yrs. Our overarching hypothesis to be examined here is that tactile-based IPV trauma exposure during late adolescence increases the sensitivity of threat circuitry, and we propose a cross-species translational study to examine molecular and physiological analyses of the RDoC Acute Threat construct.

PI_NAMEs: BALE, TRACY L (contact);JOVANOVIC, TANJA

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: 17q21;Acute;Adolescence;Adolescent;Adult;Adult women;Age;age group;Behavior;Biological;Biological Markers;biomarker identification;Birth;black men;Black race;black women;Brain;Cations;Characteristics;Childhood;Chronic;cohort;Collection;Complex;conditioned fear;Data;designer receptors exclusively activated by designer drugs;Development;Discrimination;Disease Outcome;disorder risk;emotional abuse;experience;Exposure to;extracellular vesicles;Freezing;Fright;Galvanic Skin Response;Gene Cluster;Health;Human;Individual;insight;Interpersonal Violence;Intervention;Keratin;keratinocyte;life span;Light;Link;Longitudinal cohort;Measures;men;Mental Health;Merkel Cells;Molecular;mouse model;multimodality;Mus;nanoparticle;Neurites;Neuroendocrine Cell;Neurons;neurophysiology;novel;novel marker;Outcome;Pathway interactions;Physiological;Piezo 2 ion channel;Play;Population;Post-Traumatic Stress Disorders;potential biomarker;Production;programs;prospective;Proteins;Proteomics;Psychophysiology;Puberty;Reporting;Research Domain Criteria;Resources;response;RiboTag;Risk;Role;Sensory;Sensory Thresholds;Skin;specific biomarkers;Startle Reaction;Stimulus;Stress;Tactile;tactile stimulation;Testing;Tissues;Touch sensation;transcriptomics;translational study;Trauma;trauma exposure;violence exposure;Woman;Women's study;young adult;zeta potential

PROJECT_TITLE: Extracellular vesicles as biomarkers of trauma exposure and PTSD risk


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: NARRATIVE Kaposi’s sarcoma-associated herpesvirus (KSHV) causes Kaposi’s Sarcoma and B cell lymphomas. KSHV expresses 12 miRNA genes and a number of viral long noncoding RNAs, including anti-sense and circular RNAs.  Using ribonomcs techniques we demonstrated that KSHV infection leads to de-regulation of cellular lncRNAs in  a miRNA-dependent and -independent fashion. The main focus of this project is to increase our understanding  of how viral short and long noncoding RNAs contribute to viral disease, and specifically to tumor formation.

PI_NAMEs: RENNE, ROLF F (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;AIDS related cancer;angiogenesis;B-Cell Lymphomas;B-Lymphocytes;Binding Proteins;bioinformatics pipeline;Biological Assay;Biology;Cells;circular RNA;Code;Collaborations;comparative;Comparative Study;Complex;CRISPR interference;crosslink;Data;Data Analyses;Data Set;density;Development;Endothelial Cells;Experimental Designs;Funding;gammaherpesvirus;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;Global Change;glucose metabolism;Goals;Growth;Herpesviridae;Herpesviridae Infections;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hybrids;In Vitro;in vivo;in vivo Model;innovation;Investigation;Kaposi Sarcoma;Knock-out;Laboratories;Link;Lymphoproliferative Disorders;lytic replication;MALAT1 gene;Malignant Neoplasms;Messenger RNA;Methods;MicroRNAs;migration;miRNA expression profiling;Modeling;Multiomic Data;multiple omics;Mus;mutant;novel;novel therapeutic intervention;Pathogenicity;Pathway interactions;Phenotype;primary effusion lymphoma;programs;Proliferating;Proteins;Protocols documentation;Publications;Publishing;Reporting;RNA;RNA Splicing;Role;Sampling;Signal Pathway;South Africa;Specimen;Structure;success;System;Techniques;tissue culture;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Treatment Protocols;tumor;Tumor Suppressor Proteins;tumorigenesis;Universities;Untranslated RNA;Validation;Viral;viral interferon regulatory factor;Viral Pathogenesis;viral RNA;Virus;Virus Diseases;virus genetics;Work;Xenograft procedure

PROJECT_TITLE: "Project 1" KSHV short and long noncoding RNAs and alteration of host IncRNA expression


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

PHR: Project Narrative The transforming human gammaherpesviruses EBV and KSHV establish stable latent infections in B cells,  providing a lifelong reservoir of virus that can contribute to the development of malignant disease. Thus, defining  the mechanisms that govern long-term latency and tumorigenesis is critical for designing rational strategies to  prevent disease. In work here, we will use a mouse model of gammaherpesvirus infection and tumorigenesis to  defined the mechanisms by which viral noncoding RNAs shape critical B cell signaling pathways to promote virus  dissemination, latency and tumorigenesis.

PI_NAMEs: TIBBETTS, SCOTT A. (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Animal Model;B-Cell Lymphomas;B-Lymphocytes;Biological;Biological Models;Biology;Cell Physiology;Chronic;chronic infection;Code;Collaborations;Comparative Study;Data;defined contribution;Development;digital;Disease;Epstein-Barr virus encoded RNA 1;Epstein-Barr virus encoded RNA 2;Event;experimental study;Foundations;gammaherpesvirus;Genes;Genetic Transcription;Goals;Hematogenous;Herpesviridae;HIV;Human;Human Herpesvirus 4;Human Herpesvirus 8;Hyperplasia;Immunocompromised Host;Immunologics;in vivo;in vivo evaluation;infected B cell;Infection;innovation;latent infection;Lesion;Link;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;MicroRNAs;Molecular;mouse model;Mus;mutant;Nature;novel;Outcome;Pathogenesis;Pathway interactions;Peripheral;Phenotype;Play;prevent;programs;Proteins;rational design;recombinant virus;Regulation;Reporting;Repression;RNA;Role;Shapes;Signal Pathway;Site;small hairpin RNA;Small RNA;Surface;System;Technology;Testing;Transcript;Transfer RNA;Translations;tumor;tumor progression;tumorigenesis;Untranslated RNA;Viral;Viral Physiology;Viral reservoir;Virus;Work

PROJECT_TITLE: "Project 3" Defining the in vivo function of ncRNAs during MHV68 latency and lymphomagenesis


NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: MORRIS, ZACHARY SCOTT;WEICHERT, JAMEY P (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: adaptive immunity;Antigens;cancer immunotherapy;cancer therapy;Canis familiaris;clinically relevant;Companions;Complex;Core Facility;cytokine;Development;Dose;Dose Rate;dosimetry;Immune;Immune system;Immune Tolerance;immunogenicity;immunoregulation;Immunosuppression;Immunotherapy;in vivo;Malignant Neoplasms;Modeling;Molecular Target;Mus;neoplastic cell;Predisposition;Program Research Project Grants;programs;Radiation;Radioisotopes;Radionuclide therapy;research facility;response;Site;Testing;Therapeutic;tumor;tumor microenvironment;Tumor-infiltrating immune cells;vector


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

PHR: Project Narrative In this proposal we will carry out the first unbiased screens and genetic interaction mapping of all lncRNAs and their associated protein partners in human and murine macrophage cells. We will generate genetic mouse models of candidate genes to show their critical role in contributing to sepsis in vivo. Our aim is to identify those functionally conserved lncRNAs involved in the regulation of critical biological processes in macrophages.

PI_NAMEs: CARPENTER, SUSAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Binding Proteins;Biological Process;Biology;Candidate Disease Gene;Cell Line;Cells;Complex;Data;deep sequencing;gene network;Genes;Genetic;Genetic Transcription;Genome;Goals;Human;Human Genome;Immune response;in vivo;Inflammatory;innovation;insight;Macrophage;Maps;mouse model;Mus;Names;novel;Pathway interactions;Proteins;Rapid screening;Regulation;Reporter;RNA;Role;Sepsis;Signal Transduction;Technology;Untranslated RNA

PROJECT_TITLE: High throughput functional characterization of lncRNAs in macrophage biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prevention;Sleep Research;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Chronic pain and opioid use disorder are, respectively, leading causes of disability and accidental death in the US; there is a public health imperative to identify modifiable risk factors so that these inter-related problems can be better understood and prevented. Sleep disturbance is a common and highly treatable risk factor for both chronic pain and OUD and we hypothesize that sleep disturbance increases risk for pain and OUD by dysregulating brain mu-opioid receptor (MOR) signaling. To answer this question, we will conduct a randomized controlled experiment in healthy individuals, testing the effects of two common sleep disruption patterns experience by the majority of individuals with chronic pain and OUD (insomnia pattern and sleep apnea pattern) on: 1) brain imaging measures of MOR signaling, and 2) the analgesic response and abuse liability profile of hydromorphone, a prototypical opiate drug.

PI_NAMEs: SMITH, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Absence of pain sensation;Abstinence;abuse liability;Accidents;Adult;alcohol use disorder;Amygdaloid structure;Analgesics;Anterior;antinociception;Arousal;Attenuated;Brain;Brain imaging;Brain region;carfentanil;Cerebrum;Cessation of life;chronic pain;chronic pain patient;chronic painful condition;cingulate cortex;clinical pain;Clinical Research;Cocaine use disorder;cost;Cross-Sectional Studies;Data;disability;Disease;disorder risk;Dopamine;Dose;endogenous opioids;Epidemic;experience;experimental group;experimental study;Feeling;Functional disorder;hedonic;Hour;Human;Hydromorphone;Impairment;Individual;individual variation;Insula of Reil;interest;Knowledge;Laboratories;Link;male;Measures;Mediating;Midbrain structure;modifiable risk;Molecular;Morphine;mu opioid receptors;neural circuit;Neural Pathways;neurobiological mechanism;neuroimaging;neurotransmission;novel;novel therapeutics;Nucleus Accumbens;Opioid;opioid abuse;Opioid agonist;Opioid Analgesics;opioid misuse;opioid overdose;Opioid Receptor Binding;opioid use;opioid use disorder;overdose risk;Pain;pain inhibition;Pain management;Pain Measurement;pain sensitivity;Pain Threshold;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Placebo Control;poor sleep;Positron-Emission Tomography;Practice Management;pre-clinical;Prefrontal Cortex;preservation;prevent;Prevention;Procedures;Property;prototype;Public Health;Randomized;Receptor Activation;receptor function;Receptor Signaling;response;Rest;reward circuitry;reward processing;Rewards;Risk;Risk Factors;Role;Sales;Scanning;Sensory;Severities;sex;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep pattern;sleep quality;Sleeplessness;Testing;Time;Ventral Striatum;Woman;Work

PROJECT_TITLE: Effects of experimental sleep disruption and fragmentation on cerebral Mu-opioid receptor function, Mu-opioid receptor agonist analgesia, and abuse liability.


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PI_NAMEs: BLANKE, CHARLES D. (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adolescent and Young Adult;Clinical Trials;Collaborations;Data;Dedications;Development;Ensure;improved;Infrastructure;Link;member;Mission;Monitor;operation;Organizational Policy;organizational structure;Policies;Population;Procedures;Process;Safety;Southwest Oncology Group;Speed;Structure

PROJECT_TITLE: SWOG Network Group Operations Center of the NCTN


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Hearing Loss;Infectious Diseases;Prevention;Rehabilitation

ORG_CITY: IOWA CITY

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Bacteria often stick to the surfaces of implants, causing infections that can lead to implant removal or replacement. Additionally, biomaterial implantation may result in significant scarring that decreases the effectiveness of a number of biologically important devices, including cochlear implants. To improve ultimate performance and safety, we are developing a coating for implants using light that prevents bacteria from adhering and growing while also decreasing scarring, thereby, improving the overall benefit and safety of implants.

PI_NAMEs: HANSEN, MARLAN R (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TITLE: Reduction of Intracochlear Trauma and Fibrosis Using Dual Network, Zwitterionic Hydrogel Thin Films on Cochlear Implant Surfaces

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PI_NAMEs: CHAN, TIMOTHY AN-THY (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Accounting;Animal Experimentation;Animals;Cancer Center;Clinic;Clinical;Clinical Management;Clinical Trials;Collaborations;Combined Modality Therapy;Communication;Comprehensive Cancer Center;Core Facility;Data;Development Plans;Documentation;Education;Enrollment;Ensure;experience;Feedback;Florida;Funding;Genomics;Goals;Grant;Human;Human Resources;human subject;Human Subject Research;innovation;Institution;Investigation;Laboratories;Leadership;Manuscripts;meetings;Monitor;Multi-Institutional Clinical Trial;Multicenter Trials;National Cancer Institute;Office of Administrative Management;operation;Oral;Performance;Preparation;programs;Progress Reports;Radiation;Research;Resources;Schedule;Services;Site;Study Subject;System;Time;Training;Treatment Efficacy;Universities;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PI_NAMEs: KLUG, NICHOLAS RYAN (contact);NELSON, MARK T

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Accounting;Adenosine;Animal Model;Area;Blood;Blood capillaries;Blood Circulation;Blood flow;Brain;brain health;Brain Hypoxia;Brain Hypoxia-Ischemia;Brain imaging;brain pericytes;cardiovascular health;Central Nervous System;cerebral capillary;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Circulation;Chronic;Clinical;Dementia;Endothelial Cells;extracellular;Functional disorder;Hypoxia;innovation;insight;Ischemia;Mediating;Microvascular Dysfunction;Modeling;Molecular;Nerve Degeneration;Nervous System Trauma;Neurons;Nutrient;Oxygen;Pathologic;Pathology;Pericytes;Physiological;Play;Regulation;response;Role;Signal Induction;Signal Transduction;Signaling Molecule;Stimulus;Structure;Surface;Testing;Thalamic structure;Tube;Vascular Dementia;Vascular Diseases;Vasodilation;Vermont;white matter

PROJECT_TITLE: Role of Brain Pericyte KATP Channels in Physiological Hypoxia Sensing and Deficient Blood Flow Regulation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KAMIN MUKAZ, DEBORA  (contact);NELSON, MARK T

PROJECT_TERMS: Address;Adult;Awareness;Biological;Biological Markers;Black race;black women;brain health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;classism;Cohort Studies;County;Disparity;Future;Gender;health data;health inequalities;high risk;indexing;Individual;Inflammation;Inflammatory;intersectionality;Knowledge;Link;Longitudinal Studies;Measures;men;Molecular Epidemiology;Policies;Preventive measure;Proteomics;Race;Reasons for Geographic And Racial Differences in Stroke;Research;Research Design;Sampling;Sexism;Social Identification;social structure;Socioeconomic Status;Structural Racism;theories;United States;Vermont;Visit;White Women;Woman

PROJECT_TITLE: Cardiovascular Health and Inflammation: Intersectional Impact of Structural Racism, Structural Sexism, and Structural Classism


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Both HIV and Mycobacterium tuberculosis (Mtb) establish life-long infections that, despite the development of antiretroviral therapy and antibiotics, cause millions of deaths every year, emphasizing the need to develop a cure. This proposal aims to define the methods by which HIV and Mtb evade immune-mediated clearance by characterizing their common target cell, the macrophage, and how this cell acts to shield these pathogens from immune responses. Insight into these mechanisms will help identify macrophage-specific pathways that can be exploited to make these infected cells more susceptible to immune-mediated clearance, potentiating the development of cure-based strategies for HIV and Mtb infection.

PI_NAMEs: CLAYTON, KIERA L. (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;Antibiotics;antigen-specific T cells;Antigens;antiretroviral therapy;Apoptosis;Area;Award;Candidate Disease Gene;Cardiovascular Diseases;Caspase;CD4 Positive T Lymphocytes;CD94 Antigen;Cell Communication;Cell Death;cell killing;cell type;Cells;Cessation of life;Characteristics;Chronic;comorbidity;cytokine;Cytomegalovirus;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;design;Development;Doctor of Philosophy;Exhibits;Failure;Future;Gene Expression Profile;Goals;Granzyme;HIV;HIV Infections;HIV/TB;Human;Immune;Immune Evasion;Immune response;Immunity;Immunology;Individual;Induction of Apoptosis;Infection;Inflammation;inhibitor;innovation;insight;Knock-out;Laboratories;Ligands;Liver diseases;Macrophage;Mediating;Methods;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Natural Killer Cells;Nature;neutralizing antibody;pathogen;Pathway interactions;Penetrance;Pharmaceutical Preparations;Postdoctoral Fellow;Predisposition;prevent;Productivity;programs;Proteins;Publishing;Research;Resistance;response;side effect;Supervision;systemic inflammatory response;T cell response;T-Lymphocyte;T-Lymphocyte and Natural Killer Cell;therapeutic development;therapy design;therapy development;Tissues;Tuberculosis;Viral;virological synapse;virology;Virus;Work

PROJECT_TITLE: Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Neurodegenerative disorders are a significant public health and economic problem affecting about 450 million people worldwide are the leading cause of disability and ill-health according to world health organization. The main objective of the proposal is the development, validation and translation of a non-invasive diffusion MRI assay, that enable efficient encoding of diffusion parameter space to characterize the neurodegenerative processes that drive the progression of neurodegeneration. We validate the framework in a cohort of Huntington's disease, with the prospect of extending these studies to understand the neurodegenerative cascade in the entire class of neurodegenerative diseases, including Parkinson's and Alzheimer's.

PI_NAMEs: MANI, MERRY  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TITLE: Fast Multi-dimensional Diffusion MRI with Sparse Sampling and Model-basedDeep Learning Reconstruction

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Stanford Clinical Center will continue to lead and actively participate in the research objectives of the Chronic Pancreatitis, Diabetes, and Pancreas Cancer (CPDPC) Consortium by recruiting into the 3 key clinical studies. This administrative supplement will support the collection of bio-specimens from these studies per protocol. The results of these studies will provide insights that will inform new diagnostic tests and treatments.

PI_NAMEs: PARK, WALTER GWANG-UP (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Administrative Supplement;Childhood;chronic pancreatitis;clinical center;Clinical Research;Collection;cost;Diabetes Mellitus;Diagnosis;Diagnostic tests;Enrollment;epidemiology study;Evaluation;Funding;insight;International;Lead;Longitudinal cohort study;Malignant neoplasm of pancreas;novel diagnostics;Pancreatitis;Patient Recruitments;Patients;Productivity;prospective;Protocols documentation;recruit;Research;Secondary to;Testing;translational study

PROJECT_TITLE: The Stanford Clinical Center for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: Antigens;Clinical Trials;Contractor;Contracts;Databases;Development;Documentation;efficacy study;Engineering;Equipment and supply inventories;Glycopeptides;Good Manufacturing Process;HIV vaccine;HIV-1;Human;immunogenicity;In Vitro;Investigational Drugs;Laboratories;Laboratory Animals;manufacture;manufacturing run;nanoparticle;National Institute of Allergy and Infectious Disease;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;Process;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;research clinical testing;Running;Testing;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: cGMP Manufacturing of Glycopeptide Immunogen Nanoparticle Vaccine


FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

NIH_SPENDING_CATS: Contraception/Reproduction;Disability Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PROJECT_TERMS: Address;Adolescent;Age;Agreement;Attitude;Birth;Child;Chronic Disease;Computer Assisted;Computer software;computerized;computerized data processing;Data;Data Analyses;Data Collection;data dashboard;data integration;data management;Data Set;data submission;disability;Documentation;Event;experience;Fertility;Funding;Goals;Guidelines;Health;health of the mother;Health Status;high risk;Human Development;improved;Infant;Infant Health;Institutional Review Boards;Internet;Interviewer;Lead;Life;Live Birth;Maintenance;Maternal Health;Measures;Medical center;Mission;Modernization;Monitor;multiple data sources;National Institute of Child Health and Human Development;Personal Satisfaction;Phase;population based;post pregnancy;Postpartum Women;Pregnancy;Pregnant Women;Prevention;Printing;Process;programs;Questionnaires;rehabilitation research;reproductive;Reproductive Health;Research;Research Personnel;Risk Assessment;Site;societal costs;Spanish/English;Surveys;System;Telephone;Telephone Interviews;Testing;Training;United States;Woman;Women's Group;Women's Health

PROJECT_TITLE: PREGNANCY RISK ASSESSMENT MONITORING SYSTEM (PRAMS) SURVEY


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_NAME: MICROBIOTIX, INC

PI_NAMEs: BOWLIN, TERRY  (contact)

PROJECT_TERMS: Advanced Development;Bacterial Antibiotic Resistance;Bacterial Drug Resistance;bacterial resistance;biodefense;candidate selection;Chemistry;Clinical assessments;Combating Antibiotic Resistant Bacteria;efficacy evaluation;Emerging Communicable Diseases;lead optimization;manufacture;pathogen;pre-clinical;product development;Pseudomonas aeruginosa;research and development;Research Support;safety assessment;Therapeutic;therapeutic candidate;therapeutic development

PROJECT_TITLE: Development of Therapeutic Products for Antibiotic Resistant Bacteria


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The goals of this project are to 1) examine preferences for diabetes care among adult Samoans recently diagnosed with diabetes using a discrete choice experiment, 2) prospectively estimate the associations between diabetes care and glycemic outcomes among adult Samoans, and 3) longitudinally assess diabetes care decision-making and coping strategies. The project will use the tools and methodologies of health economics, longitudinal quantitative and qualitative approaches, and implementation science to comprehensively assess diabetes care experiences and provide formative data necessary to build evidence- based, patient centered and sustainable diabetes interventions and treatment programs

PI_NAMEs: RIVARA, ANNA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Address;Adult;Age;Applications Grants;Applied Research;Award;behavioral and social science;Biometry;career;career development;Caring;Chronic;Chronic Care;Chronic Disease;Clinical;cohort;Communication;Communities;coping;Coping Skills;Data;Data Collection;Decision Making;design;Development;diabetes control;Diabetes Mellitus;Diagnosis;Dimensions;Disease;Distress;Doctor of Philosophy;Economics;Epidemic;Epidemiology;evidence base;experience;experimental study;Foundations;Funding;Future;glycemic control;Glycosylated hemoglobin A;Goals;Government;Grant;health care service utilization;health economics;Health Policy;Health Services;Hospitals;Human Genetics;implementation science;Individual;Infrastructure;innovation;International;Intervention;intervention program;Interview;Investigation;K-Series Research Career Programs;Linear Models;Linear Regressions;Logistic Regressions;Manuscripts;Measures;medication compliance;Medicine;men;Mentors;Mentorship;Methodology;Methods;mid-career faculty;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Outcomes Research;Pacific Islander;Pacific Islands;Participant;patient oriented;Patients;Peer Review;Persons;phenomenological models;Physiological;pilot test;Policies;policy recommendation;Population;Positioning Attribute;Postdoctoral Fellow;preference;Preparation;Prevalence;professor;prospective;Public Health Schools;Qualitative Methods;recruit;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Training;Resource-limited setting;Samoa;Samoan;Science;Scientist;Self Management;sex;skills;social;Structure;symposium;Testing;Time;tool;Training;Training Programs;treatment program;United States National Institutes of Health;Universities;willingness to pay;Woman;Work

PROJECT_TITLE: The Diabetes Clinical outcomes Associated with Retention and Engagement in Care, in Samoa (Diabetes CARE)