NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PI_NAMEs: FREEDMAN, MATTHEW L (contact)

PROJECT_TERMS: Address;anti-cancer research;Area;Award;career;Communities;Dana-Farber Cancer Institute;Data;Development;Discipline;Disparate;Ensure;Ethnic Population;Extramural Activities;Faculty;Feedback;Female;Fostering;Foundations;Funding;Funding Opportunities;Future;Goals;Grant;improved outcome;innovation;interest;Malignant neoplasm of prostate;Monitor;novel strategies;Patient-Focused Outcomes;Peer Review;Peer Review Grants;Program Research Project Grants;programs;Prostate;Qualifying;racial population;recruit;Research;Research Personnel;Research Project Grants;Resources;translational cancer research;translational potential;Woman;Work

PROJECT_TITLE: Developmental Research Program


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: RASSOOL, FEYRUZ VIRGILIA (contact)

PROJECT_TERMS: acronyms;Address;Advisory Committees;anti-cancer research;Baltimore;Basic Science;biobank;Biometry;Cancer Center;cancer therapy;Catchment Area;Cigarette;Clinic;Clinical;Clinical Investigator;Collaborations;college;community engagement;Community Outreach;Comprehensive Cancer Center;County;Detection;Development;Diagnosis;Diagnostic;Direct Costs;Doctor of Medicine;Doctor of Philosophy;Early Diagnosis;early phase clinical trial;Faculty;Flow Cytometry;Funding;Funding Agency;Genomics;Goals;Grant;Hematologic Neoplasms;hormone related cancer;Human;Image;improved;In Vitro;in vivo;Industry;innovation;Investigational Therapies;Journals;Laboratories;Laboratory Study;Leadership;liquid biopsy;Malignant Neoplasms;Maryland;Measurement;Medical;Medical center;medical schools;member;Mission;Molecular;Molecular Biology;molecular carrier;Molecular Target;Nanotechnology;NCI Center for Cancer Research;neoplasm immunotherapy;new technology;novel;novel therapeutic intervention;novel therapeutics;Pathology;Patient-Focused Outcomes;Peer Review;Pharmacy Schools;Population Sciences;Positioning Attribute;pre-clinical;pre-clinical research;Preclinical Testing;professor;programs;Public Health Schools;Publications;Radiation Oncology;Radiation Protection;Radiation therapy;recruit;Research;research clinical testing;Research Personnel;Research Priority;response;School Dentistry;Services;Solid Neoplasm;Source;structural biology;Suggestion;System;Testing;Therapeutic;Translating;translational scientist;Treatment outcome;tumor immunology;Universities;virology

PROJECT_TITLE: Experimental Therapeutics Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: (RESEARCH PLAN- OVERALL) PROJECT NARRATIVE Approximately 10% of families in the United States care for children and adults with intellectual or developmental disabilities, extracting a substantial financial and emotional toll on those with IDD conditions and their families. Our goal is to foster a collaborative, multidisciplinary, cutting-edge community of scientists at CHOP, Penn, and beyond to develop new neurobiologically-based, patient-centered approaches to therapies for these disorders.

PI_NAMEs: MARSH, ERIC D;SCHULTZ, ROBERT THOMAS (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: 22q11;Adult;Advocacy;Advocate;Affective;auditory processing;Award;Behavior;Behavioral;behavioral outcome;Biological Markers;biomarker identification;Biometry;Brain;Cardiology;career;career development;Caring;Chalk;Child;Child Care;Clinical;Clinical Research;clinical translation;Cognitive;Collaborations;Communities;community building;community center;cost effective;Cultural Diversity;Data Analytics;data integration;Data Science;design;Development;Developmental Disabilities;disability;Disability research;Discipline;Disease;Doctor of Philosophy;Down's Syndrome;Early identification;Education;effective intervention;Emotional;Ensure;Experimental Designs;Faculty;Family;Fostering;Foundations;Funding;Future;Future Generations;Genes;Genetic;Genetic Determinism;Genetic Risk;genetic variant;Genomics;Goals;Government Officials;Grant;Human;improved;Individual;induced pluripotent stem cell;Infant;innovation;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;language outcome;Lead;Leadership;Magnetoencephalography;Measures;Medical;Medical Research;member;Mission;Motor;multidisciplinary;Mus;National Institute of Neurological Disorders and Stroke;Nervous System;neural circuit;Neurobiology;Neurodevelopmental Disability;neuroimaging;neuromechanism;Neuronal Differentiation;Neurosciences;new technology;novel;novel marker;Output;Pathogenesis;patient oriented;Patients;Pediatric Hospitals;Pennsylvania;Perinatology;pharmacologic;Philadelphia;Policy Maker;Population;Positioning Attribute;post-doctoral training;Prader-Willi Syndrome;Pre-Clinical Model;professor;Program Development;programs;recruit;Reproducibility;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Sample Size;Scientist;Sensory;Series;Services;social;sound;Structure;support network;Techniques;Technology;Testing;therapy development;Time;Training;Training Programs;transition to adulthood;translational impact;Translational Research;Turner's Syndrome;Underrepresented Minority;United States;Universities;Vocabulary;Work

PROJECT_TITLE: The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/Penn


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: Uterine fibroids are common noncancerous tumors that can cause women to have severe bleeding, pelvic pressure and pain, urinary dysfunction, and adverse pregnancy outcomes. Although hysterectomy has traditionally been the most common treatment, many women seek alternative procedures that remove just the fibroid and preserve the uterus (myomectomy), leave the fibroids in the uterus but destroy fibroid tissue by heat (radiofrequency ablation) or by blocking blood flow (uterine artery embolization), or destroy the uterine lining to stop bleeding (endometrial ablation); however, there is no information on what happens to women after they have these treatments. Our goal is to study how well these hysterectomy alternatives improve fibroid symptoms and prevent the need for future fibroid treatment.

PI_NAMEs: JACOBY, VANESSA ;NICHOLSON, WANDA K;STEWART, ELIZABETH A;WEGIENKA, GANESA REBECCA (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Ablation;Address;adverse pregnancy outcome;Affect;African American Women;Aftercare;Age;Anemia;Black race;black women;Blood flow;Blood Transfusion;Caring;Characteristics;Clinical;clinical care;clinical decision-making;Clinical effectiveness;clinical predictors;cohort;Cohort Studies;common treatment;comorbidity;comparative effectiveness;Comparative Effectiveness Research;Data;data harmonization;Decision Making;Development;Diabetes Mellitus;Effectiveness;Endometrial;Endometrium;Enrollment;ethnic diversity;evidence base;Excision;Failure;Fertility;Fibroid Tumor;flexibility;follow-up;Functional disorder;Future;Goals;Guidelines;Hemorrhage;Hysterectomy;Image;Impairment;improved;Incidence;indexing;individual patient;Infertility;Intention;Intestines;Knowledge;Location;Longitudinal cohort;longitudinal design;Longterm Follow-up;Menopausal Status;Menopause;Morbidity - disease rate;novel;Online Systems;Outcome;Pain;Participant;patient engagement;patient oriented;Patient Self-Report;Patient-Focused Outcomes;Patients;Pelvic Pain;Pelvis;Population;Postmenopause;precision medicine;Predictive Factor;predictive tools;Pregnancy;Premenopause;preservation;pressure;prevent;Procedures;Provider;Psychometrics;Quality of life;Questionnaires;Race;racial diversity;Radiofrequency Interstitial Ablation;Recurrence;Registries;Reporting;Reproductive History;Research Personnel;Retreatment;Risk;risk prediction;Selection for Treatments;Site;Standardization;Statistical Methods;Statistical Models;success;symptomatic improvement;Symptoms;Testing;Time;Tissues;Treatment Effectiveness;Treatment Failure;tumor;United States;urinary;Uterine Fibroids;Uterine myomectomy;Uterus;White Women;Woman;Work

PROJECT_TITLE: Long Term Effectiveness of Uterine Sparing Fibroid Treatments

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PI_NAMEs: BELTRAN, HIMISHA  (contact)

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Award;Basic Science;Cancer Center;Cancer Research Project;career;career development;catalyst;Clinical;Clinical Sciences;clinical translation;Collaborations;diversity and inclusion;early-career faculty;Education;Electronic Mail;Ethnic Population;Faculty;Financial Support;Fostering;Funding;Goals;graduate student;Individual;Infrastructure;innovation;Institution;instructor;K-Series Research Career Programs;Leadership;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;meetings;member;Mentors;Mentorship;Mission;Monitor;next generation;outreach;Play;Population;Population Sciences;Positioning Attribute;Postdoctoral Fellow;Process;professor;programs;Prostate;racial population;recruit;Request for Applications;Research;Research Personnel;Resources;Role;social media;success;supportive environment;System;Talents;Training;translational cancer research;Underrepresented Populations;web site;Woman

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: LONDON SCH/HYGIENE & TROPICAL MEDICINE

ORG_ZIPCODE: WC1E 7HT

PHR: PROJECT NARRATIVE This project will investigate the risk of TB transmission from people with TB to children in their households. We will compare transmission risk between HIV-positive people taking antiretroviral therapy (ART) to HIV-positive people who are not taking ART, and compare people with TB who have symptoms to those who do not have symptoms (the "walking well"). The results will help target strategies to find people with TB who are infectious, so that TB transmission can be halted.

PI_NAMEs: GRANT, ALISON  (contact)

PROGRAM_OFFICER_NAME: JONES, FATIMA D

PROJECT_TERMS: Accounting;Address;Adult;Africa;antiretroviral therapy;Area;Bacteriology;Biological Assay;case finding;Cause of Death;Characteristics;Child;Communities;comparative cost effectiveness;comparison group;cost;cost effective;cost effectiveness;Data;Dedications;Development;Diagnostic;Digital Radiography;Early identification;Economic Models;Effectiveness of Interventions;Enrollment;Epidemic;Epidemiology;Goals;Gold;Health;Health system;HIV;HIV Seronegativity;HIV Seropositivity;Household;Immune;improved;Incidence;indexing;Individual;insight;Interruption;Intervention;Knowledge;Mass Screening;mathematical model;Measures;Methodology;Modeling;Morbidity - disease rate;mortality;multiple chronic conditions;Mycobacterium tuberculosis;Natural History;Notification;novel;Pathway interactions;Patients;Persons;Population;population based;population survey;Prevalence;programs;public health intervention;radiological imaging;Reporting;Research Institute;Resources;restoration;Risk;Rural;screening;screening program;South Africa;Sputum;success;Surveys;Symptoms;Testing;Time;transmission process;Tuberculosis;Tuberculosis diagnosis;Walking

PROJECT_TITLE: Defining drivers of TB transmission in the era of universal ART, and implications for finding the walking well

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(50)R]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

PHR: Project Narrative The relevance of the Health People 2030 Scientific Meetings to public health is the reduction of infections caused by E. coli STEC, Salmonella, Campylobacter, Listeria; and the number of Norovirus outbreaks.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: Healthy People 2030


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: RELEVANCE (See instructions): Retinal diseases including diabetic retinopathy, diabetic macular edema and age related macular degeneration, inherited dystrophies, as well as retina-vascular diseases are major causes of blindness and vision loss in the United States and worldwide. Epidemiologic studies show that vision loss from these entities becomes more common with age. (Klein 2013) Instruments continue to be developed and improved which provide enormous amounts of structural as well as functional (microperimetry,

PI_NAMEs: AN, CHEOLHONG ;BARTSCH, DIRK-UWE G;FREEMAN, WILLIAM R. (contact);NGUYEN, TRUONG Q

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: 3-Dimensional;Adopted;Age;Age related macular degeneration;Alzheimer's Disease;Angiography;Area;Artificial Intelligence;Blindness;Blood Vessels;Clinical;clinical decision-making;Clinical Trials;Color;Compensation;Computer software;Consensus;contrast imaging;Cornea;Data;Data Collection;data management;Data Set;Database Management Systems;Databases;deep learning;density;Detection;Devices;diabetic;Diabetic Retinopathy;Diagnosis;Digital Imaging and Communications in Medicine;Disease;disease diagnosis;Disease Outcome;Disease Progression;Electronic Health Record;electronic medical record system;Environmental Risk Factor;Epidemiology;epidemiology study;Evaluation;Evaluation of Risk Factors;Eye;Eye Movements;Fluorescein Angiography;Functional Imaging;Fundus;fundus imaging;genetic risk factor;Goals;Image;Image Analysis;image processing;image registration;imaging modality;imaging platform;imaging Segmentation;imaging system;Imaging technology;improved;Indocyanine Green;Inherited;Instruction;instrument;Intuition;Lasers;Length;Lesion;Light;Link;macula;macular edema;Medical;Medical Imaging;Methods;Modality;Morphologic artifacts;Motion;Movement;Multimodal Imaging;multimodality;Natural History;Ophthalmologist;Ophthalmoscopes;Optical Coherence Tomography;Optics;Outcome;Output;Pathology;Patients;Pattern;Performance;Perimetry;Peripheral;Persons;Pharmaceutical Preparations;pre-clinical;Predictive Value of Tests;Preparation;Process;Proliferating;Protocols documentation;Race;Reading;Research;Resolution;Retina;Retinal Diseases;retinal imaging;Scanning;screening;Secure;Severities;sex;Signal Transduction;Source;statistics;structural imaging;Structure;System;Techniques;Technology;Testing;Thick;Three-Dimensional Imaging;Time;Tissues;tool;training data;treatment response;two-dimensional;United States;vascular abnormality;Vascular Diseases;visual tracking;Visualization;Work

PROJECT_TITLE: SCH: Multimodal Retina Image Alignment and Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: MARTIN, STUART S (contact)

PROJECT_TERMS: Acceleration;acronyms;Address;Advanced Malignant Neoplasm;Affect;African American population;anti-cancer research;Aromatase Inhibitors;Baltimore;Basic Science;biobank;Biology;Biometry;breast cancer metastasis;cancer health disparity;cancer imaging;cancer recurrence;cancer stem cell;cancer therapy;Catchment Area;Cigarette;Clinical Research;Clinical Trials;Collaborations;college;community engagement;Community Outreach;Comprehensive Cancer Center;County;demographics;Development;Diagnosis;disparity reduction;Doctor of Medicine;Doctor of Philosophy;Enrollment;Flow Cytometry;Funding;Funding Agency;Genomics;Goals;Grant;hormone related cancer;hormone therapy;Hormones;Human;Image;improved;Interdisciplinary Study;Intervention Trial;Investigational Therapies;Laboratories;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Maryland;Mediating;Medical;Medical center;medical schools;member;Mission;Molecular Biology;Morbidity - disease rate;mortality;NCI Center for Cancer Research;neoplasm immunotherapy;Neoplasm Metastasis;new technology;Pathology;Patients;Peer Review;Pharmaceutical Preparations;Pharmacy Schools;Phase III Clinical Trials;Physiology;Population Sciences;precision medicine;professor;programs;Public Health Schools;Publications;Recommendation;recruit;Recurrence;Research;Research Personnel;Research Priority;Resistance;Resistance development;Resources;response;School Dentistry;Services;Source;structural biology;System;targeted treatment;Therapeutic Intervention;therapeutic target;Tissues;Translational Research;treatment response;tumor;tumor immunology;Underrepresented Minority;Universities;virology;Work

PROJECT_TITLE: Hormone Related Cancers Program


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Diabetes remains a major cause of vision loss in the United States and new therapies are needed. The disease process includes loss of normal retinal blood vessel barrier properties, damaging the retina and leading to loss of vision. Here, we explore the possibility of utilizing natural cytokines involved in retinal vessel development, to restore blood vessel function in models of diabetic retinopathy.

PI_NAMEs: ANTONETTI, DAVID  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: adeno-associated viral vector;Adult;Age;angiogenesis;Binding;Biological Products;Biology;Blindness;Blood capillaries;Blood Vessels;Blood-Retinal Barrier;Cell Culture Techniques;Cell Fractionation;Cell membrane;cofactor;Collaborations;college;Complex;Contrast Sensitivity;cytokine;Data;Development;Diabetes Mellitus;Diabetic Retinopathy;Disease;Edema;Elements;Endophthalmitis;Endothelial Cells;Endothelium;Environment;epidemiologic data;Gene Deletion;gene replacement;Genes;Goals;Health;in vivo;Inflammatory;inhibitor;Injections;Injury;insight;Ischemia;Lasers;Light Coagulation;Link;London;macular edema;Maintenance;Mediating;Membrane;Modeling;Molecular;Mus;Mutation Analysis;National Eye Institute;Natural regeneration;Neural Retina;Neuroglia;novel;novel therapeutics;Onset of illness;Pathologic;Pathway interactions;Patients;Permeability;preservation;prevent;Process;Property;protein expression;Proteins;Rattus;receptor;Regulation;repaired;Research;Resistance;restoration;Retina;retina blood vessel structure;retinal damage;Retinal Diseases;Risk;Robin bird;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Small Interfering RNA;solute;temporal measurement;Testing;Therapeutic;Tight Junctions;Transcriptional Activation;Transgenic Organisms;United States;Universities;Vascular Diseases;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular Permeabilities;Viral Vector;Vision;Visual Acuity;WNT Signaling Pathway;World Health Organization

PROJECT_TITLE: Mechanisms of Retinal Vascular Permeability in Diabetes

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE To survive and thrive in a dynamic environment, humans require the ability to focus on a task at hand while ignoring distraction (“cognitive stability”) as well as the ability to switch focus to a different task when goals or circumstances change (“cognitive flexibility”). The context-appropriate matching of cognitive stability and flexibility levels to different challenges in everyday life is severely impaired in many clinical conditions, but the underlying mechanisms of how the human brain dynamically regulates stability and flexibility are presently not well understood. This project combines a novel behavioral test of concurrent stability and flexibility adjustments with computational modeling of the underlying cognitive processes, and electrical and blood-flow measurements of brain activity, which together will allow us to reveal how the brain strategically adapts cognitive stability and flexibility to changing demands, and by inference, how these processes might be impaired in clinical populations.

PI_NAMEs: COGAN, GREGORY B;EGNER, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: Adaptive Behaviors;Address;adjudication;Allium cepa;Anterior;Attention;Attention deficit hyperactivity disorder;Basal Ganglia;base;Basic Science;Behavior;behavior test;Behavioral;blood flow measurement;Brain;cingulate cortex;Clinical;Cognitive;cognitive control;cognitive process;cognitive reappraisal;Computer Models;Conflict (Psychology);cooking;cost;Data;Data Set;Diffusion;distraction;Electroencephalography;Environment;Exposure to;Failure;flexibility;Functional Magnetic Resonance Imaging;Geometry;Goals;Human;Impairment;innovation;Investigation;Lateral;Learning;learning algorithm;Life;Literature;Measures;Mediating;millisecond;Modeling;Monitor;neural;Neuroanatomy;Neurocognitive;Neurologic;neuromechanism;novel;Parietal;Patients;Phase;Population;Process;Protocols documentation;Psychological reinforcement;Reaction Time;Readiness;Reading;Recipe;Regulation;Resolution;response;Role;Shapes;simulation;Site;Slice;Stimulus;stimulus processing;success;temporal measurement;Testing;Time;Variant;Work

PROJECT_TITLE: Neurocognitive mechanisms of control over cognitive stability and flexibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BURNABY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SIMON FRASER UNIVERSITY

ORG_STATE: BC

ORG_ZIPCODE: V5A 1S6

PHR: PROJECT NARRATIVE  The EHE initiative has presented an unprecedented opportunity to reduce the burden of HIV/AIDS across the nation. The simulation modeling platform and underlying evidence synthesis we have developed provides a flexible tool to help decision-makers allocate funds to maximize the impact of our efforts towards EHE. With this renewal application we will expand the reach and impact of our work, advance our efforts on identifying strategies to address the inequities in healthcare access in HIV prevention and treatment, and ultimately reach the ambitious goals of the EHE initiative by 2030.

PI_NAMEs: NOSYK, BOHDAN  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Accounting;Address;Advisory Committees;AIDS prevention;Black race;care systems;Centers for Disease Control and Prevention (U.S.);Cities;Collaborations;Collection;Communication;Communities;Community Health;cost effectiveness;Cost Effectiveness Analysis;Country;County;COVID-19;COVID-19 pandemic;dashboard;Data;Decision Making;Development;Diagnosis;Disease Outbreaks;disparity reduction;dissemination science;Early Diagnosis;economic evaluation;Economic Models;Effectiveness;Elements;Epidemic;epidemic preparedness;Epidemiology;Equity;ethnic disparity;evidence base;Evidence based intervention;flexibility;Funding;Geography;Goals;Health;Health Benefit;health care availability;health care disparity;health difference;health economics;health equity promotion;health inequalities;Health Services Accessibility;Health system;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Human Resources;implementation process;implementation science;implementation strategy;improved;Infection;Infrastructure;innovation;Intervention;Justice;knowledge translation;Latinx;Laws;local economy;Methodology;Modeling;models and simulation;novel strategies;Outcome;Output;Persons;Phase;Policies;Policy Maker;pre-exposure prophylaxis;prevent;Prevention;prevention service;Public Health;Public Health Schools;Puerto Rico;Race;rapid detection;Research;Research Personnel;Resources;response;Rural;scale up;service delivery;service intervention;service programs;Services;Sexual Partners;Testing;tool;translational approach;transmission process;treatment services;United States;United States Health Resources and Services Administration;Universities;Update;Washington;Work

PROJECT_TITLE: Localized economic modeling to support implementation of the Ending the HIV Epidemic initiative

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CLEVELAND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The gaseous signaling molecule nitric oxide is known to have important roles in regulating gene expression through numerous transcriptional pathways, enabling a cell to adapt to its environment by dynamically regulating the set of genes it transcribes. We have recently determined that nitric oxide, through covalent S- nitrosylation of cysteine residues in target proteins, also regulates alternative splicing of mRNAs, a crucial mechanism by which cells expand the protein-coding capacity of the genome. The goal of this project is to understand the effect of nitric oxide in regulation of alternative splicing through S-nitrosylation of a key RNA- binding regulatory protein, defining a novel fundamental role by which NO exerts global effects on gene expression profiles in health and disease.

PI_NAMEs: SCHINDLER, JOSEPH CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Abbreviations;Address;Affect;Alternative Splicing;Area;Biochemical;bioinformatics pipeline;Biology;Cardiovascular system;cell growth regulation;Cell Physiology;cell type;Cells;Co-Immunoprecipitations;Code;cofactor;combinatorial;crosslink;Cues;Cultured Cells;Cysteine;Data;Defect;Development;Disease;Environment;environmental change;Environmental Exposure;Environmental Science;Enzymes;Epigenetic Process;epigenome;Exposure to;Family;fluorescence imaging;Foundations;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Proteins;Genes;genetic regulatory protein;Genetic Transcription;Genome;Germ Lines;Goals;Health;Histones;hypoxia inducible factor 1;Immunologics;Immunoprecipitation;in utero;In Vitro;Knock-in;Laboratories;Maps;Mass Spectrum Analysis;Mediating;Messenger RNA;MicroRNAs;Modification;Molecular;mouse model;Mus;Mutant Strains Mice;Mutate;Mutation;National Institute of Environmental Health Sciences;Neurologic;Nitric Oxide;novel;novel strategies;Nuclear;Nuclear Magnetic Resonance;Pathologic;Pathway interactions;Physical condensation;Physiological;Play;Polypyrimidine Tract-Binding Protein;Post-Translational Protein Processing;prevent;Production;Property;Protein Conformation;protein function;Proteins;Proteomics;Publishing;Regulation;Reporting;Research;response;Ribonucleoproteins;RNA;RNA Binding;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;S-Nitrosothiols;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Site;Spliceosomes;Structure;Sulfhydryl Compounds;System;Testing;Time;Tissues;Transcript;transcription factor;transcriptome;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Nitric oxide as a novel regulator of alternative splicing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PI_NAMEs: RAMSEY, BONNIE W (contact)

PROJECT_TERMS: Area;Center Core Grants;Child;Collaborations;Communication;Core Facility;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Databases;Development;Education;effectiveness evaluation;Electronic Mail;Ensure;Evaluation;Feedback;Fertilization;Fostering;Funding;Goals;Grant;Human Resources;Infrastructure;innovation;Institution;International;Joints;Kidney;Kidney Diseases;Knowledge;Laboratories;Lead;Link;Measurement;meetings;member;Metabolic;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;novel;Performance;Pilot Projects;post-doctoral training;Productivity;Program Evaluation;programs;Publications;recruit;Research;Research Institute;Research Personnel;Research Priority;Resource Sharing;Science;Science Enrichment;Series;Services;Specimen;Strategic vision;success;symposium;Training;Translational Research;Universities;Update;Washington;web site;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: HOFFMAN, LUCAS R (contact)

PROJECT_TERMS: Address;Adverse effects;airway epithelium;Animal Model;Animals;Antibiotics;Area;Attention;Bacteria;Bacteroides;base;behavioral study;Biochemical;Biological;Biological Assay;Biology;Body System;bone;Cells;Cellular biology;Clinical;Clinical Microbiology;Clinical Research;clinically relevant;Collaborations;Communities;Consultations;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;design;digital imaging;digital pathology;digital repositories;Disease;Disease Outcome;dysbiosis;Endocrine;Endocrine system;Epithelium;Equipment;Escherichia coli;Evolution;experience;Experimental Designs;experimental study;Fostering;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Genomics;Goals;Growth;gut microbiota;Histocytochemistry;Histopathology Facility;Image;Immune;Immune response;Immunohistochemistry;improved;In Situ Hybridization;In Vitro;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;innovation;interest;Investigation;Kidney;Laboratories;Life Expectancy;Link;Liver;Lung;Malignant Neoplasms;Measures;metabolome;Methods;Microbe;microbial;Microbiology;microbiome;microbiome specimens;Microscopy;Morbidity - disease rate;Mucous Membrane;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel;Organ;Outcome;Pancreas;pathogen;Pathogenesis;Pathologic;Pathology;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;pre-clinical research;programs;Proteome;Proteomics;Reagent;Renal function;Reproducibility;Research;Research Personnel;Research Support;Resources;Respiratory System;Role;Sampling;Services;Slide;Specialist;Specimen;stool sample;Suggestion;Surface;targeted imaging;Techniques;Tissues;tool;Training;transcriptome;translational approach;Translational Research;treatment response;vaccine response;Work

PROJECT_TITLE: Host Microbe Core


ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: Overall Core Project Narrative The Institute Core Grant provides funds for vision scientists from 20 investigator-initiated R01 grants to support four research modules at the Schepens Eye Research Institute including Animal Resources, Flow Cytometry, Laboratory Computer Applications and Morphology. The Modules allow individual researchers to have access to expertise and state-of-the-art facilities that are not available in their laboratories, supporting important and interdisciplinary investigation of ocular diseases.

PI_NAMEs: D'AMORE, PATRICIA ANN (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Anesthesia procedures;Animal Experimentation;Animal Experiments;animal resource;Animals;Automobile Driving;Biological Markers;Breeding;Cell Count;Cells;clinical examination;Code;Collection;Computer software;Computer Systems;computerized;Computers;Confocal Microscopy;Consult;Consultations;Core Grant;cryostat;Data;Detection;Development;digital imaging;Electron Microscopy;Eligibility Determination;epon;Equipment;experience;Eye;Eye diseases;Flow Cytometry;Fluorescence;Frozen Sections;Funding;Grant;Histology;Housing;Human Resources;Image Analysis;image processing;Individual;Instruction;Investigation;Laboratories;Lasers;Light;light microscopy;Machine Learning;Maintenance;Measures;Methacrylates;Microdissection;Microscope;Microscopy;monolayer;Morphology;Mus;mutant mouse model;Operative Surgical Procedures;Paraffin;Pharmaceutical Preparations;Phase;Population;Postoperative Care;Principal Investigator;Procedures;Process;programs;Protocols documentation;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Scanning;Scanning Electron Microscopy;Schedule;Scientist;Services;software development;Sorting;Speed;Supervision;System;Technical Expertise;Techniques;Technology;Testing;tissue preparation;Tissues;Training;Transmission Electron Microscopy;Vision;Vision research;Visual

PROJECT_TITLE: Core Grant for Vision Research


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Genetics;Human Genome;Lung;Microbiome;Rare Diseases

PI_NAMEs: SALIPANTE, STEPHEN J (contact)

PROJECT_TERMS: Area;Automobile Driving;Bacteria;bacterial genome sequencing;base;Cells;Computer Analysis;computer infrastructure;Computer software;computing resources;Consultations;cost;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Data Analyses;data management;data quality;data sharing;Dedications;digital;Disease;Escherichia coli;Experimental Designs;Functional disorder;Funding;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Generations;Genetic;genome-wide;Genomics;Grant;gut dysbiosis;gut microbes;gut microbiome;gut microbiota;Health;host-microbe interactions;Human;Human Resources;Immune response;Inflammation;innovative technologies;instrument;instrumentation;Laboratories;life span;lung microbiome;member;Metabolic;Metabolism;Metagenomics;Methodology;Methods;Microbe;microbial community;Microbial Genetics;Microbial Physiology;Microbiology;microbiome;microbiome research;Molecular;new technology;next generation sequencing;novel;novel sequencing technology;pathogen;Patients;Peer Review;Performance;Physiology;Play;Production;Productivity;Publications;Quantitative Reverse Transcriptase PCR;Real-Time Systems;Research;Research Personnel;Resources;Respiratory System;Ribosomal RNA;Role;Services;Signal Transduction;System;Technical Expertise;Techniques;technological innovation;Technology;Tissues;tool;Training;Transcript;transcriptome sequencing;Translational Research;transposon sequencing;Universities;Washington;Work

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: WEBER, DAVID JOSEPH (contact)

PROJECT_TERMS: acronyms;anti-cancer research;Area;Baltimore;Basic Science;biobank;Biology;Biometry;cancer cell;cancer stem cell;Catchment Area;Cell Death;Cigarette;Clinic;Clinical;Clinical Trials;Collaborations;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;design;Development;Diagnosis;Direct Costs;DNA Damage;DNA Repair;Doctor of Philosophy;drug candidate;drug testing;Flow Cytometry;France;functional outcomes;Funding;Funding Agency;Gene Expression;Gene Expression Process;Genetic Transcription;Genomic Instability;Genomics;Goals;Grant;Hematologic Neoplasms;hormone related cancer;Human;Image;improved;Individual;innovation;Investigational Therapies;Journals;Laboratories;Malignant Neoplasms;Maps;Maryland;Medical;Medical center;medical schools;member;Mission;Molecular;Molecular Biology;NCI Center for Cancer Research;neoplasm immunotherapy;Neoplasm Metastasis;New Agents;novel;novel therapeutic intervention;Oncogenic;Pathology;Pathway interactions;Patient-Focused Outcomes;Peer Review;Pharmacy Schools;Population Sciences;pre-clinical research;Process;programs;Public Health Schools;Publications;Research;Research Personnel;Research Priority;Research Support;RNA;School Dentistry;Scientist;Services;Signal Pathway;Signal Transduction;Solid Neoplasm;Source;structural biology;System;targeted treatment;Testing;Therapeutic;therapeutic target;Translating;Translation Initiation;Translations;Treatment outcome;tumor growth;tumor immunology;Tumor Suppression;Universities;Validation;virology;Work

PROJECT_TITLE: Molecular and Structural Biology Program


NIH_SPENDING_CATS: Clinical Research;Cost Effectiveness Research;Cystic Fibrosis;Lung;Orphan Drug;Rare Diseases

PI_NAMEs: GOSS, CHRISTOPHER HOOPER (contact)

PROJECT_TERMS: Address;Adult;Aging;Area;base;Basic Science;Biological Assay;Biometry;Biostatistical Methods;care burden;Chronic;Clinical;clinical database;clinical development;clinical outcome measures;Clinical Research;Clinical Trials;Clinical Trials Design;Collaborations;comparative;comparative effectiveness;cost effectiveness;Cost Effectiveness Analysis;Cost effectiveness research;cost utility analysis;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;design;Development;Development Plans;Diabetes Mellitus;Disease;drug development;Endocrine;Ensure;Epidemiologic Methods;Fostering;Functional disorder;Funding;Gastrointestinal tract structure;Hepatic;Hepatobiliary;Human;improved;Infrastructure;innovation;interest;International;Investigation;Investigational Drugs;Kidney;Kidney Diseases;Kidney Failure;Link;Liver;Malignant neoplasm of gastrointestinal tract;Malnutrition;National Institute of Diabetes and Digestive and Kidney Diseases;nephrotoxicity;next generation;novel;novel therapeutic intervention;novel therapeutics;Outcome Measure;Pancreas;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Physiological;Population;Positioning Attribute;programs;Protocols documentation;repository;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk;Secondary to;Services;Symptoms;Therapeutic;therapeutic development;Training;Translational Research;translational scientist;translational study;Translations;United States Food and Drug Administration

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Lung;Pediatric;Rare Diseases

PI_NAMEs: SINGH, PRADEEP K (contact)

PROJECT_TERMS: Area;Budgets;Cancer Center;Center for Translational Science Activities;Child;Clinical;Clinical Research;Collaborations;Communities;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Diabetes Mellitus;Digestive System Disorders;experience;Focus Groups;Funding;Gastroenterology;Health;high risk;improved;Inflammation;Institution;interest;Joints;Kidney;Kidney Diseases;Link;Medical center;meetings;Microbiology;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;novel;nutrition;outreach;Pediatric Hospitals;Persons;Pilot Projects;Productivity;programs;Publications;Pulmonary Cystic Fibrosis;recruit;Research;Research Institute;Research Personnel;respiratory;Running;Scientist;Series;System;Translational Research;Translations;United States National Institutes of Health;Universities;Washington;web site;Work

PROJECT_TITLE: Pilot and Feasibility program


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Kidney Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a practical, proactive approach to management of geriatric problems in hemodialysis clinics. This research will fill the gap in geriatric care for older adults receiving hemodialysis and potentially increase quality of life and decrease healthcare utilization. The proposed research is relevant to the part of the NIA’s mission to maintain health, well-being, and function for older adults with multiple chronic conditions.

PI_NAMEs: HALL, RASHEEDA K (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Adult;aged;Agreement;Automobile Driving;Blinded;Caregivers;Caring;Clinic;Communities;Control Groups;cost;Data;design;Development;Dialysis patients;Dialysis procedure;effectiveness evaluation;Elderly;Ensure;Evaluation;experience;falls;Feedback;Focus Groups;Future;Geriatric Assessment;Geriatrics;Goals;Guidelines;Health;health care service utilization;Hemodialysis;Home;Human Resources;Impaired cognition;improved;innovation;instrument;Interview;Kidney Diseases;Long-Term Care;Malnutrition;Measures;Medical;Mental Depression;Mind;Mission;Mobility disability;model development;Modeling;multidisciplinary;multiple chronic conditions;Names;novel;older adult;Oncology;Outcome;Outpatients;Participant;patient engagement;Patient Outcomes Assessments;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;personalized care;Pharmaceutical Preparations;Phase;Physical Function;Population;primary outcome;Probability;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Resources;response;routine care;screening;Self Administration;Social support;Source;standard of care;Structure;success;Surveys;Syndrome;telehealth;Testing;Time;treatment as usual;Visit;Work

PROJECT_TITLE: Integration of Geriatric Care into Dialysis Clinics

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Down Syndrome;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: ROBINSON, MICHAEL BYRNE (contact)

PROJECT_TERMS: Adult;Advisory Committees;Advocacy;Advocate;Affective;Applied Research;Area;auditory processing;Award;Basic Science;Behavioral;Biometry;Budgets;Cardiology;career development;Chalk;Child;clinical translation;Cognitive;cognitive ability;Collaborations;Communication;Communities;community organizations;Computing Methodologies;cost effectiveness;Data;data integration;Data Science Core;Development;Disability research;Disease;Education;educational atmosphere;Educational workshop;Electroencephalography;Electronic Health Record;Electronics;Ensure;Environment;Etiology;Faculty;Family;Fostering;Functional disorder;Funding;gene therapy;Genetic;Genetic Risk;genetic variant;Genomics;Goals;Grant;Growth;Human;Individual;induced pluripotent stem cell;Infant;innovation;Innovative Therapy;Institution;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;Journals;Language;Lead;Leadership;Magnetic Resonance Imaging;Magnetoencephalography;Measures;meetings;member;Mentors;Mission;Modernization;Monitor;Motor;mouse model;multidisciplinary;National Institute of Child Health and Human Development;National Institute of Neurological Disorders and Stroke;neural circuit;Neurodevelopmental Disability;neuroimaging;Neurosciences;next generation;novel therapeutics;Oncology;Parents;Pathogenesis;patient advocacy group;Patients;Pediatric Hospitals;Pennsylvania;Perinatology;Phenotype;Philadelphia;Physicians;Positioning Attribute;post-doctoral training;Pre-Clinical Model;processing speed;professor;Program Development;programs;Publications;recruit;Reporter;Reproducibility of Results;Research;Research Institute;Research Project Grants;Research Support;Research Training;Resources;Risk;satisfaction;Scientist;Series;Site;skills;social;success;support network;Surveys;System;systematic review;Technology;technology validation;Training;Training Activity;Training Programs;translational goal;Translational Research;Universities;Utilization Review;Vision;web site;Work


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Lung;Sleep Research

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE This project seeks to understand the role of hypoxia on the pathogenesis of glucose dysregulation in a high altitude model of sleep disordered breathing. We will also determine whether specific patterns of hypoxemia predispose to hyperglycemia during sleep in sleep disordered breathing patients. This study will establish whether targeting hypoxemia during sleep could improve glucose levels at night, potentially preventing or delaying the progression of diabetes and its sequelae.

PI_NAMEs: PHAM, LUU VAN (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Address;Air;Altitude;Award;Biometry;blood glucose regulation;Breathing;career;career development;Chronic;Clinical;Clinical Trials;cohort;Cohort Studies;Collaborations;Conduct Clinical Trials;Continuous Glucose Monitor;Continuous Positive Airway Pressure;Critical Care;Cross-Over Studies;Cross-Over Trials;Data;Data Analyses;Dedications;design;Development;Development Plans;Diabetes Mellitus;diabetes pathogenesis;Disease;Dose;Ensure;Environment;Exhibits;experience;Exposure to;Faculty;Funding;Glucose;Glucose Intolerance;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Home;Hour;Hyperglycemia;hypertension control;Hypoxemia;Hypoxia;Impairment;improved;Insulin Resistance;interstitial;Intervention;Laboratories;Link;Lung;Medicine;meetings;member;Mentors;Mentorship;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolism;meter;Methods;Modeling;nocturnal Hypoxemia;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;Oxygen;Oxyhemoglobin;Pathogenesis;Pathogenicity;Patients;Pattern;Peru;Peruvian;Physicians;Placebos;Population;prevent;Pulse Oximetry;Randomized;Recording of previous events;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Research Training;response;Risk;Role;role model;Sea;Severities;Sleep;Sleep Apnea Syndromes;Stimulus;Structure;Subgroup;supplemental oxygen;Supplementation;temporal measurement;Testing;Time;Training;United States National Institutes of Health;Universities;Virulence Factors;volunteer;Wakefulness;wearable monitor;Withdrawal

PROJECT_TITLE: Impact of Nocturnal Hypoxemia on Glucose during Sleep in High Altitude Sleep Disordered Breathing

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Relevance to Public Health While there have been many advances in the treatment of liver cancer over the past half century, approximately 85% of patients with this disease will die within five years of diagnosis. Algorithmically controlled electroporation (ACE) is a new cancer therapy which uses ultrashort electrical pulses designed for the treatment of inoperable liver cancers. This Academic-Industrial Partnership proposal aims to develop the instrumentation and protocols necessary to translate ACE to the clinic and demonstrate the safety, efficacy and reproducibility of the treatment in a relevant spontaneous large animal model of disease.

PI_NAMEs: SANO, MICHAEL BENJAMIN (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Ablation;Abscopal effect;adaptive immune response;Adherence;Admission activity;Aftercare;Algorithmic Software;Algorithms;Animal Disease Models;Animal Model;Animals;anti-cancer;Antitumor Response;Apoptotic;Appointment;aspirate;bench to bedside;bile duct;Biological Assay;Biomedical Engineering;Blood specimen;Blood Vessels;cancer cell;Cancer Etiology;cancer therapy;Canis familiaris;Cell Death;Cell membrane;chemotherapy;Clinic;Clinical;Clinical Trials;Coagulative necrosis;cohort;college;commercialization;Comprehensive Cancer Center;curative treatments;Dangerousness;Data;design;Development;Devices;Diagnosis;Diagnostic Neoplasm Staging;Disease;Dose;electric field;electric impedance;Electroporation;Electroporation Therapy;Environment;Evaluation;Excision;experience;experimental study;Family suidae;Fine needle aspiration biopsy;Fire - disasters;Flow Cytometry;follow-up;gastrointestinal;Generations;Genomics;Goals;Hepatobiliary;Heterogeneity;Histologic;Human;Immunologist;In Vitro;in vitro Model;in vivo;individualized medicine;Industrialization;industry partner;Inflammatory;Institution;instrument;instrumentation;Interdisciplinary Study;Intervention;invention;Joints;Life;Liver;liver cancer patient;lymph nodes;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Marketing;Medical;Medical Device;medical schools;Metastatic Neoplasm to the Liver;minimally invasive;Modality;Modeling;Monitor;mortality;multidisciplinary;Necrosis;neoplastic cell;Nerve;novel;Oncologist;Oncology;Operative Surgical Procedures;Organ;Outcome;Pathologist;Patient Admission;Patients;peripheral blood;Phase;Physiologic pulse;Positioning Attribute;pre-clinical;preservation;prevent;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;Primary Neoplasm;product development;Production;Prognosis;Protocols documentation;Public Health;Radiation therapy;Recurrence;Reproducibility;Research Personnel;Resectable;Resected;Resolution;response;Safety;safety assessment;Solid;Solid Neoplasm;Structure;Surgical complication;Surgical Oncologist;survival outcome;Survival Rate;System;Techniques;technology validation;Temperature;Testing;Therapeutic;therapy design;Time;Tissue Sample;Tissues;Toxic effect;Translating;Treatment outcome;tumor;tumor ablation;tumor growth;Unresectable;Veterinarians;Veterinary Medicine;voltage;Work;X-Ray Computed Tomography

PROJECT_TITLE: Academic-Industrial Partnership to Develop Clinical Tools for Algorithmic Irreversible Electroporation of Inoperable Tumors


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PI_NAMEs: DORGAN, JOANNE F (contact)

PROJECT_TERMS: acronyms;anti-cancer research;Baltimore;Behavior;Behavior Therapy;Behavioral;biobank;Biometry;Cancer Control;Cancer Etiology;cancer health disparity;cancer prevention;Cancer Survivorship;Catchment Area;Cigarette;Collaborations;college;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;Direct Costs;Doctor of Philosophy;Early Diagnosis;Epidemiology;Equity;Faculty;Flow Cytometry;Fostering;Funding;Funding Agency;Genetic;Genomics;Goals;Grant;Health behavior;hormone related cancer;Human;Image;implementation science;Individual;Infection;Intervention;Investigational Therapies;Laboratories;Life Style;Malignant Neoplasms;Maryland;Master of Public Health;Medical;Medical center;medical schools;medically underserved population;member;Molecular;Molecular Biology;Molecular Epidemiology;neoplasm immunotherapy;Outcome;Pain;Pathology;Peer Review;Pharmacy Schools;Population;Population Sciences;prevent;programs;Psychosocial Influences;Public Health Schools;Publications;Recommendation;Research;Research Personnel;Research Support;Risk Assessment;School Dentistry;Schools;Services;Source;structural biology;System;training opportunity;Translating;Treatment-Related Cancer;tumor immunology;United States;Universities;virology

PROJECT_TITLE: Population Science Program


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Ubiquitylation is one of the most common post-translational modifications employed by cells and is essential for gene regulation. While the ubiquitin-dependent control of gene expression during interphase is well documented, it remains incompletely understood how ubiquitin-dependent enzymes regulate transcription during mitosis, a time in which there is limited gene activity. This work will shed new light on how ubiquitin- dependent enzymes control gene expression throughout the cell cycle, and we anticipate that this mechanistic study will provide a better context for understanding ubiquitin-dependent disorders.

PI_NAMEs: OH, EUGENE  (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Aging;Biochemical;Cell Cycle;Cells;Chromatin;Chromosomes;combat;Development;Disease;Ensure;Enzymes;Essential Genes;Excision;Future Generations;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomic Segment;Genomics;Higher Order Chromatin Structure;Histone H2B;Histones;Homeostasis;in vivo;insight;interdisciplinary approach;Interphase;Measurement;Memory;Metaphase;Mitosis;Mitotic Chromosome;Modification;Nerve Degeneration;Post-Translational Protein Processing;Proteins;RANK protein;Reporting;Site;spatiotemporal;Therapeutic;Time;Ubiquitin;Work

PROJECT_TITLE: Control of histone ubiquitylation during the cell cycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research

ORG_CITY: TOLEDO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TOLEDO

PHR: Project Narrative The proposed educational plan will develop holistic medical need-driven design and device commercialization pipelines that expand from the freshman through super-senior years. The proposed activities will help engineering faculty and clinical faculty prepare the next generation biomedical engineering workforce. These engineers will be able to work effectively in multidisciplinary teams; have skills in idea generation and refinement; have social competence and skills to communicate with healthcare professionals; and, most importantly, design and translate new medical device ideas into products to improve human health and quality of life.

PI_NAMEs: YILDIRIM-AYAN, EDA  (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Address;Area;Biomedical Engineering;career;Clinical;clinical care;Collaborations;college;commercialization;Communication;Creativeness;Critical Thinking;design;Devices;Diagnosis;Education;education planning;education research;Educational Curriculum;Educational process of instructing;Engineering;Environment;experience;Faculty;Fortification;Generations;Health;Health Professional;Healthcare;Human;ideation;Immersion;improved;Industry;innovation;Intellectual Property;Knowledge;Knowledge acquisition;Learning;Legal patent;manufacture;Marketing;Medical;Medical center;Medical Device;Medical Device Designs;Medicine;Mentors;multidisciplinary;next generation;Nursing Faculty;Pathway interactions;Play;Process;Production;programs;protective pathway;prototype;Quality of life;Regulatory Pathway;Rehabilitation therapy;Research;Role;skills;social skills;student mentoring;Students;Translating;undergraduate student;Universities;Validation;Work

PROJECT_TITLE: Biodesign-based learning platform fortified with clinical immersion and medical device commercialization pathway


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Disability Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PI_NAMEs: SCHULTZ, ROBERT THOMAS (contact)

PROJECT_TERMS: Acute;Address;Advertisements;Age;Animals;Architecture;Area;Behavior;Bioinformatics;Biological Markers;Biometry;Brain;Clinic;Clinical;Clinical and Translational Science Awards;Clinical assessments;clinical phenotype;clinical translation;Clinical Trials;Code;cohort;Cohort Studies;Collaborations;Communities;computable phenotypes;Computational Linguistics;Computer software;Computer Vision Systems;Consultations;Contracts;Custom;Data;Data Analyses;Data Analytics;data archive;data dashboard;Data Element;data harmonization;data integration;data management;Data Science Core;Data Set;data submission;data visualization;Database Management Systems;Databases;design;Developmental Disabilities;Diagnostic;digital phenotyping;disability;Disability research;Education;Electronic Health Record;Eligibility Determination;Exclusion Criteria;Facial Expression;falls;Family;Gait;Genes;Genetic;Genomics;Goals;Hospitals;Household;Human;Individual;innovation;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interactive visualization;Language;Leadership;Legal;Libraries;Light;Link;Machine Learning;Maps;Measurement;Measures;Mediation;medical specialties;Mission;National Institute of Mental Health;neural;neural circuit;neuroimaging;Neuropsychology;Newsletter;non-verbal;novel;Outcome Measure;Patient Recruitments;Patients;Phase;Phenotype;phenotypic data;Pre-Clinical Model;Preparation;Primary Care;Process;programs;Protocols documentation;Provider;psychologic;Quality Control;Questionnaires;recruit;Reporting;Reproducibility;Reproducibility of Results;Research;Research Personnel;Research Project Grants;research study;Research Support;Resource Allocation;Resources;response;Sampling;Schools;Science;Services;Site;social media;Speech;Structure;Techniques;Technology;Text;tool;Training;Translating;Translational Research;Treatment outcome;Visualization software;web site

PROJECT_TITLE: Clinical Translational Core


ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Overall Narrative The proposed U54 program Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor -- Immunotherapy Combinations (ST-Analytics) is designed to develop the recent conceptual advance that targeted inhibitor + cancer immunotherapy (IT) combination treatments may yield significantly greater patient benefit if those treatments are administered in sequence rather than as monotherapies or as simultaneously administered combinations.

PI_NAMEs: HEATH, JAMES R. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Acceleration;Address;Adoptive Cell Transfers;Algorithms;Automobile Driving;biobank;Biological;Biopsy;Calibration;cancer immunotherapy;Cell Physiology;Cells;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Combination immunotherapy;combinatorial;Combined Modality Therapy;Communities;computing resources;Coupled;Data;Databases;demographics;design;Development;Dimensions;Disadvantaged;disease model;Distal;Dose;Education and Outreach;Educational Models;Environment;Environment Design;Epigenetic Process;Evaluation;Genetic Transcription;Immune;immune checkpoint blockade;Immune system;Immunologic Factors;Immunooncology;Immunotherapy;in silico;in vivo;Individual;inhibitor;inhibitor therapy;Internships;K-12 Education;Kinetics;Knowledge;Lead;Leadership;Malignant Neoplasms;Measurement;medical schools;Melanoma;Metastatic malignant neoplasm to brain;Mitogen-Activated Protein Kinase Inhibitor;model design;Modeling;mouse model;multiple omics;Nature;Neoplasm Metastasis;Outcome;outreach;outreach program;Patients;Pharmaceutical Preparations;Pilot Projects;Play;prevent;Primary Neoplasm;programs;Proteomics;recruit;Research;Research Personnel;Research Project Grants;Resistance;Resources;Role;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Self-Examination;Series;spatiotemporal;Structure;System;Systems Biology;Therapeutic;Time;Tissues;tool;transcriptomics;tumor;tumor-immune system interactions;Visual;Work

PROJECT_TITLE: Spatiotemporal Tumor Analytics for Guiding Sequential Targeted-Inhibitor: Immunotherapy Combinations (ST-Analytics)


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Estrogen;Eye Disease and Disorders of Vision;Menopause;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Glaucoma is the leading cause of irreversible blindness worldwide and is an important women’s health issue since women represent 59% of glaucoma patients. Menopause and altered estrogen levels are associated with changes in intraocular pressure (a known risk factor for glaucoma) and modulate biomechanical properties and protein expression tissues throughout the body (also potential risk factors for glaucoma). This proposal studies how menopause and topical estrogen therapy affect risk factors associated with glaucoma at the functional and mechanistic levels.

PI_NAMEs: FEOLA, ANDREW J (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Affect;Age;age effect;aged;Animal Model;Animals;aqueous;Atomic Force Microscopy;Binding;biomechanical test;Biomechanics;Blindness;Blood Vessels;clinical translation;cohort;Connective Tissue;Contralateral;Data;Elderly;Estrogen deficiency;Estrogen Receptor 2;Estrogen Receptors;Estrogen Therapy;Estrogens;Event;experimental study;Eye;Eye Development;Female;Genetic Polymorphism;Glaucoma;Goals;high intraocular pressure;hormone therapy;Individual;insight;Life;Link;Literature;male;Measurement;Measures;men;Menopause;Metabolic Pathway;middle age;Modeling;Mutation;normotensive;Norway;novel therapeutics;Ocular Hypertension;Open-Angle Glaucoma;Outcome Measure;Ovariectomy;Pathway interactions;Patients;Pelvic floor structure;Persons;Physiologic Intraocular Pressure;Physiological;Population;Postmenopause;Premature Menopause;Premenopause;prevent;Process;Property;protein expression;Proteins;Rattus;Rattus norvegicus;Relative Risks;Resistance;Risk;Risk Factors;sex;Structure;surgical menopause;Surgical Models;Tissues;tonometry;Trabecular meshwork structure;Woman;Women's Health

PROJECT_TITLE: Impact of Menopause on the Aqueous Outflow Pathway


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PI_NAMEs: CAO, XUEFANG  (contact)

PROJECT_TERMS: acronyms;Adverse effects;Antitumor Response;Baltimore;Basic Science;biobank;Biometry;Calibration;Cancer Burden;cancer cell;cancer immunotherapy;Catchment Area;cell growth;Cell Therapy;Cells;Cigarette;Clinical Trials;Collaborations;college;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;Dedications;Development;Direct Costs;Disease;Doctor of Medicine;Doctor of Philosophy;faculty support;Flow Cytometry;Funding;Funding Agency;Genomics;Goals;Grant;hormone related cancer;Human;Image;Immune;immunoregulation;Immunosuppression;Immunotherapy;Infection;Inflammation;Inflammatory Response;innovation;Interdisciplinary Education;Interdisciplinary Study;Investigational Therapies;Journals;Knowledge;Laboratories;Malignant - descriptor;Malignant Neoplasms;Maryland;Medical;Medical center;medical schools;member;Molecular Biology;Monitor;NCI Center for Cancer Research;neoplasm immunotherapy;novel diagnostics;novel therapeutics;Pathology;Peer Review;Pharmacy Schools;Population Sciences;programs;Public Health Schools;Publications;Regulatory Pathway;Research;Research Personnel;Research Support;Role;School Dentistry;Services;Signal Transduction;Source;structural biology;System;Translating;Translational trial;Treatment Protocols;tumor;tumor immunology;Universities;virology

PROJECT_TITLE: Tumor Immunology and Immunotherapy Program


ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Center for Sleep in Autism Spectrum Disorder As many as 80% of children with Autism Spectrum Disorder (ASD) experience sleep disruptions including sleep fragmentation and delayed sleep onset. Animal data demonstrate sleep is essential for brain maturation, including neuronal development and synaptic plasticity, but sleep impairments in ASD are frequently considered only as secondary, co-occurring symptoms. Taking advantage of the conservation of similar sleep signatures and behavior across humans and animals we will employ a multi-modal, human subjects and animal models program to determine if sleep dysregulation is central to the development and exacerbation of symptoms in ASD.

PI_NAMEs: HALLMAYER, JOACHIM F (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: actigraphy;adolescent with autism spectrum disorder;Age;aged;animal data;Animal Genetics;Animal Model;Animals;associated symptom;autism spectrum disorder;autism symptoms;autistic children;awake;Basic Science;Behavior;behavioral phenotyping;Behavioral Symptoms;Biological;Brain;Caregivers;Clinical;Cognition;cognitive function;comorbidity;Comparative Biology;Consensus;Development;Diphenhydramine;Disease;Double-Blind Method;Electroencephalography;Etiology;experience;Experimental Animal Model;Foundations;Functional disorder;gene function;Genes;Genetic Models;Genetic study;Goals;Home;Human;human subject;Impairment;improved;individuals with autism spectrum disorder;Link;Measures;Mission;model of autism spectrum disorder;multimodality;Mus;Mutation;Neurobehavioral Manifestations;neurodevelopment;neuron development;Neuronal Plasticity;Neurons;non rapid eye movement;Participant;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;Pilot Projects;Placebo Control;Polysomnography;programs;Public Health;Randomized;reduce symptoms;REM Sleep;repetitive behavior;Research;Research Personnel;Rest;Role;sex;Sleep;sleep abnormalities;Sleep Architecture;Sleep disturbances;Sleep Fragmentations;sleep onset;sleep physiology;sleep quantity;social communication;Stereotyped Behavior;Structure;Symptoms;Synapses;Synaptic plasticity;System;trait;translational approach;Translations;Zebrafish;zolpidem


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  The next generation of technologies for regenerative medicine application will be fueled by cell- derived, self-packaged therapeutics known as extracellular vesicles (EVs). We will develop a process that makes these nano-sized therapeutics attachable to a biomaterial, like Velcro®, for tissue repair and regeneration. Additionally, our industry partner will modify their workflow to make the attachable EVs widely available and easy to use for downstream consumers, including those that are advancing regenerative medicine.

PI_NAMEs: CAMPBELL, PHIL GORDON;VORP, DAVID ALAN (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: angiogenesis;Azides;Biocompatible Materials;biological systems;cell behavior;Cell-Matrix Junction;Cells;Chemistry;chronic wound;Clinical;clinical translation;commercialization;covalent bond;culture plates;Development;diabetic;Dose;Endothelial Cells;Engraftment;Evaluation;Exposure to;Extracellular Matrix;extracellular vesicles;FDA approved;Fibroblasts;Fibroins;Film;Focus Groups;Homeostasis;Human;Immobilization;immunoregulation;implantation;improved;In Vitro;Industrialization;industry partner;Infiltration;innovation;insight;interest;large scale production;Legal patent;Ligand Binding;Logistics;Mesenchymal Stem Cells;migration;Mission;Modeling;Modification;monocyte;multidisciplinary;Multipotent Stem Cells;Mus;nanosized;next generation;novel;Outcome;Phenotype;physical property;Process;Production;Proliferating;Quality Control;Rattus;Reactive Oxygen Species;regeneration potential;regenerative;Regenerative Medicine;Research;Research Personnel;Role;scale up;self-renewal;Signal Transduction;Silk;Smooth Muscle Myocytes;Surface;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Time;Tissue Engineering;tissue regeneration;tissue repair;Tissues;Tube;tumor;Vascular Graft;vascular tissue engineering;Work;wound;wound bed;wound healing;Wound models

PROJECT_TITLE: Clickable Extracellular Vesicles to Silk-Based Biomaterials for Regenerative Medicine

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Kidney Disease;Precision Medicine;Prevention;Rare Diseases

ORG_NAME: FRANCIS CRICK INSTITUTE, LTD

ORG_ZIPCODE: NW1 1AT

PHR: This translational prospective cohort study of patients with multiple tumours arising on a background of germline VHL mutation aims to comprehensively characterise and understand the molecular events associated with growth and progression of clear cell renal cancer and other VHL associated cancers. We will employ multiparametric tumour profiling to assess how the molecular landscape, the tumour microenvironment and metabolic reprogramming contribute to differences in tumour behaviour. Outputs from this research have the potential to address key question in evolutionary cancer biology: the concept of evolutionary contingency; and in parallel, to identify the triggers for tumour growth and progression, and potentially revealing therapeutic vulnerabilities.

PI_NAMEs: TURAJLIC, SAMRA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;anaerobic glycolysis;Antigen Presentation;Cancer Biology;cancer initiation;cancer prevention;Cell Lineage;Cells;Clear Cell;Clear cell renal cell carcinoma;Clinical;clinical center;clinical phenotype;Clonal Evolution;cohort;Cyst;Data Set;Disease;Environment;Environmental Risk Factor;Event;Evolution;Genome;genomic profiling;Genomics;Germ Lines;Germ-Line Mutation;Glean;Growth;Hereditary Renal Cell Carcinoma;Image;Immune;Immune system;Immunohistochemistry;Immunologic Surveillance;improved;improved outcome;Individual;Inflammatory;Inherited;Kidney;kindred;Kinetics;Lesion;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Metabolic;metabolic profile;metabolome;Methods;Microtomy;Modeling;Molecular;Molecular Profiling;multidimensional data;National Cancer Institute;neoantigens;Neoplasms in Vascular Tissue;next generation sequencing;novel;novel therapeutic intervention;Oncology;Output;Patients;Penetration;Phenotype;Pilot Projects;predictive marker;Prevention;Prognostic Marker;progression marker;Prospective, cohort study;Radiology Specialty;recruit;Renal Cell Carcinoma;Research;restraint;Role;Shapes;Site;Spatial Distribution;stable isotope;Techniques;Therapeutic;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment strategy;tumor;tumor behavior;tumor growth;tumor microenvironment;tumor progression;Tumor Tissue;Urology;Variant;VHL mutation;Von Hippel-Lindau Syndrome;Work

PROJECT_TITLE: Deciphering Clonal Evolution in Hereditary Renal Cell Carcinomas


PHR: Project Narrative  Human cells regulate the functions of proteins by decorating them with sugar molecules, a process known as glycosylation. Our project aims to understand how glycosylation controls multiprotein complexes that drive important cell biological processes. This work may reveal new therapeutic opportunities to treat diseases in which glycosylation is dysregulated, including cancer, diabetes and neurodegeneration.

PI_NAMEs: BOYCE, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: 14-3-3 Family;Ablation;Binding;Binding Proteins;Biochemical;Biological;Biological Process;Biophysics;Cell model;Cell Physiology;Cells;chromatin remodeling;comparative;Comparative Study;Complex;Cytoplasmic Protein;Cytoskeletal Filaments;Cytoskeletal Proteins;Deubiquitination;Diabetes Mellitus;Diffusion;Disease;Enzymes;Future;Genetic;Glycoproteins;glycosylation;Goals;Homo;Human;human disease;Importins;In Vitro;Individual;inorganic phosphate;insight;Intermediate Filament Proteins;Intermediate Filaments;Link;Malignant Neoplasms;Mammalian Cell;Mammals;Mediating;Methods;Modeling;Multiprotein Complexes;Mus;Nerve Degeneration;neurofilament;novel;novel therapeutics;Nuclear;Nuclear Envelope;Nuclear Import;Nuclear Pore;Nuclear Pore Complex Proteins;Nuclear Proteins;nucleocytoplasmic transport;Organelles;paralogous gene;Peptides;Phenotype;Phosphoproteins;Phosphorylation;Physiological;Polysaccharides;Post-Translational Protein Processing;Process;protein complex;protein function;protein protein interaction;Proteins;Reader;receptor;receptor binding;Regulation;Reporting;Resolution;Role;Signal Transduction;Structure;sugar;Testing;trafficking;transmission process;ubiquitin-protein ligase;Vimentin;Work;X-linked intellectual disability

PROJECT_TITLE: Cell signaling through O-GlcNAc reader proteins

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Brain Disorders;Data Science;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PI_NAMEs: PUTT, MARY E. (contact)

PROJECT_TERMS: Address;analytical tool;Area;Basic Science;behavioral phenotyping;Big Data;Big Data Methods;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;Brain Diseases;career development;Classification;Clinical Data;Clinical Medicine;clinical translation;Clinical Trials;Code;Collaborations;Communication;community center;computerized tools;Data;data integration;Data Science;Data Science Core;Data Set;deep neural network;design;Development;Disease;DNA Sequence Alteration;Doctor of Philosophy;Documentation;Education;Educational workshop;Electronic Health Record;Eligibility Determination;Epidemiology;experience;experimental analysis;Experimental Designs;experimental study;Faculty;frontier;Gene Expression;Generations;Genetic;genetic analysis;Genomics;High-dimensional Modeling;Human;improved;Informatics;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Knowledge;Leadership;Machine Learning;machine learning method;member;Mentors;Methodology;mid-career faculty;Mission;Modification;multidimensional data;Names;Natural Language Processing;novel;Observational Study;online repository;Ontology;operation;Pathology;Patients;Pattern;Pediatric Hospitals;Pediatrics;Pennsylvania;Phenotype;phenotypic data;Philadelphia;predictive modeling;Process;professor;programs;Public Health Informatics;Recording of previous events;recruit;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Resource Informatics;Sample Size;Services;Source;Statistical Data Interpretation;Statistical Methods;teacher;Techniques;Time;Training;translational medicine;translational study;Universities;unstructured data;Variant;Visualization

PROJECT_TITLE: Biostatistics & Data Science Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Narrative IPUMS CPS is essential data infrastructure for research on population health and child and family well-being in the United States. IPUMS CPS streamlines access to the Current Population Survey (CPS)—the nation’s primary source of timely data on monthly labor force statistics and the economic and social well-being of its people—by harmonizing, documenting, linking, and freely disseminating CPS data through a powerful data access platform. IPUMS CPS dramatically reduces the cost and increases the rigor and reproducibility of the research on population dynamics and population health with transformative implications for public health.

PI_NAMEs: FLOOD, SARAH M (contact);WARREN, JOHN ROBERT

PROGRAM_OFFICER_NAME: JEKIELEK, SUSAN

PROJECT_TERMS: Age;anti-racism;application programming interface;base;career;Child;Child Welfare;Communities;computerized data processing;cost;COVID-19 impact;Custom;Data;data access;Data Analyses;data infrastructure;data resource;Data Set;Data Sources;Databases;Dimensions;Documentation;economic disparity;Economics;Ensure;Explosion;Family;Family Demographies;Fertility;food security;Funding;Geography;Goals;graduate student;Health;health determinants;health inequalities;Health Insurance;Household;Immigrant;Improve Access;improved;Income;Individual;Infrastructure;innovation;Insurance Coverage;Investments;journal article;labor force participation;Labor Forces;life span;Link;Living Arrangement;Marketing;Maternal and Child Health;Measures;Metadata;migration;Mission;Mothers;National Institute of Child Health and Human Development;Nuptiality;Occupational Health;outreach;Peer Review;Personal Satisfaction;Persons;Policies;Policy Research;Population;Population Distributions;Population Dynamics;Population Growth;population health;population survey;Poverty;Public Health;Public Policy;racial minority;Recommendation;Records;Reproducibility;reproductive;Research;Research Infrastructure;Research Personnel;Research Support;Resources;Risk;Running;safety net;Sampling;Services;social;Social Well-Being;sound;Source;Specific qualifier value;statistics;Subgroup;System;Systems Analysis;Time;Tobacco use;tool;Training;United States;user-friendly;Wait Time;Weight;Woman;Work

PROJECT_TITLE: Integrated Current Population Survey Data for Population Dynamics and Health Research

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Cancer

ORG_CITY: BALTIMORE

PI_NAMEs: OWONIKOKO, TAOFEEK K (contact)

PROJECT_TERMS: acronyms;Administrator;Advisory Committees;Applications Grants;Baltimore;biobank;Biometry;Budgets;Cancer Center;Cancer Center Support Grant;cancer imaging;cancer research center director;Cancer Survivorship;Catchment Area;Cell Therapy;Cigarette;Clinical Cancer Center;Clinical Research;cohort;Collaborations;college;community engagement;Community Outreach;Comprehensive Cancer Center;cost;Counseling;Country;County;design;Doctor of Medicine;Evaluation;Evolution;Flow Cytometry;Funding;Future;Genomics;Goals;Grant;hormone related cancer;Human;Human Resources;Image;imaging program;Investigational Therapies;Laboratories;Leadership;Malignant Neoplasms;Maryland;Medical;Medical center;medical schools;Medicine;meetings;Molecular Biology;Monitor;Names;neoplasm immunotherapy;new technology;Pathology;Pharmacy Schools;Population Research;Population Sciences;Process;programs;Public Health Schools;Qualifying;Recommendation;recruit;Research;Research Personnel;School Dentistry;Scientist;Secure;Series;Services;Skin Malignancy;structural biology;Structure;System;Technology;Translational Research;tumor immunology;Universities;virology;Work

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Aging is the single greatest risk factor for the development of cancer, but how biological changes that occur during aging increase the incidence of cancer in older adults is largely unknown. This proposal examines how changes in protein homeostasis within aging blood-forming stem cells create a permissive environment for the emergence of clonal hematopoiesis and acute myeloid leukemia in older adults.

PI_NAMEs: MAGEE, JEFFREY ALAN;SIGNER, ROBERT A.J. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acceleration;Acute;Acute Myelocytic Leukemia;Adult;Affect;Age;age related;age related changes;aged;Aging;Alanine-tRNA Ligase;Attenuated;Biogenesis;Biological;biological adaptation to stress;Biological Assay;Blood;cancer initiation;Cell Aging;Cells;Cellular Stress;Chronic;Clonal Hematopoietic Stem Cell;Data;Defect;Development;Disease;DNA Sequence Alteration;DNMT3a;DNMT3a mutation;Environment;Epigenetic Process;Equilibrium;experience;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;hallmarks of aging;Heat shock proteins;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;improved;in vivo;Incidence;Investigation;leukemia;Life;Link;Longevity;Malignant - descriptor;Malignant Neoplasms;misfolded protein;mitochondrial dysfunction;Modeling;Mus;mutant;Mutate;Mutation;novel strategies;novel therapeutics;old mice;older adult;Organism;Pathway interactions;permissiveness;postmitotic;Predisposition;preservation;pressure;prevent;programs;Protein Biosynthesis;Proteins;Proteome;proteostasis;proteostasis loss;response;Risk Factors;sensor;single-cell RNA sequencing;stem cell exhaustion;stem cells;Stress;Testing;Time;Transfer RNA;Translations;young adult

PROJECT_TITLE: The influence of proteostasis loss in aging hematopoietic stem cells on leukemia initiation


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Data Science;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: PHILADELPHIA

PI_NAMEs: FALK, MARNI J (contact)

PROJECT_TERMS: Acceleration;analytical tool;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Base Sequence;Basic Science;Behavior;biobank;Biochemical;bioinformatics resource;Biology;Biomedical Research;Biostatistics Core;Brain;causal variant;Cells;Clinical Research;clinical translation;clinical trial readiness;Clinical Trials;clinically relevant;ClinVar;cohort;Collaborations;Complex;complex data;Computerized Medical Record;Copy Number Polymorphism;cost;Custom;Data;Data Files;data integration;Data Set;Data Sources;data visualization;Databases;design;Development;Developmental Disabilities;developmental disease;Disease;disease-causing mutation;DNA sequencing;Doctor of Philosophy;Education;epigenomics;Epilepsy;exome;Experimental Designs;frontier;Generations;Genes;Genetic;genetic analysis;Genetic Predisposition to Disease;genetic variant;Genome;genome wide association study;genome-wide;genomic data;Genomic DNA;Genomics;Genotype;Glutamates;Goals;Haplogroup;Individual;induced pluripotent stem cell;Informatics;informatics tool;Information Services;insight;instrument;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;International;Internet;Knowledge;Maps;Medicine;Metabolic;Mission;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial genome;Mitochondrial RNA;Modeling;Mutation;Natural History;Neurons;neurophysiology;next generation sequencing;novel;Nuclear;Outcome;Outcome Measure;Output;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patient Outcomes Assessments;Performance;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Population;Positioning Attribute;Pre-Clinical Model;programs;Publications;Quality Control;Rare Diseases;Research;Research Personnel;research study;Resources;RNA;Scientist;Self Direction;Services;Signal Transduction;single cell sequencing;Source;Subjects Selections;Surveys;Target Populations;Technology;Therapeutic;transcriptome sequencing;translational medicine;Translational Research;Variant;virtual;Visualization;Work

PROJECT_TITLE: Genomics & Data Integration Core


PROJECT_TERMS: acronyms;Area;Baltimore;Basic Science;biobank;Biometry;Cancer Center;Cancer Center Support Grant;Cigarette;Clinical;Clinical Research;Collaborations;Comprehensive Cancer Center;Data;Development;Discipline;Doctor of Medicine;Extramural Activities;Faculty;Faculty Recruitment;faculty research;faculty support;Flow Cytometry;Funding;Future;Genomics;Grant;hormone related cancer;Image;innovation;Institution;Investigational Therapies;Investments;Laboratories;Malignant Neoplasms;Maryland;medical schools;member;Mission;Molecular Biology;NCI Center for Cancer Research;neoplasm immunotherapy;novel;Pathology;Pilot Projects;Population Sciences;Process;programs;recruit;Research;research faculty;Research Personnel;Research Project Grants;Research Training;Scientist;Services;Strategic Planning;structural biology;Structure;Talents;Teacher Professional Development;Training;tumor immunology;Universities

PROJECT_TITLE: Developmental Funds


ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

PHR: Project Narrative The relevance of the AI Summit Scientific Meetings to public health is the to bring industry and regulatory members together to advance the healthcare industry’s understanding on how to best make use of artificial intelligence, and to establish industry and regulatory work teams that will collaboratively address AI challenges and develop AI solutions that will improve patient care.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: Artificial Intelligence (AI) Summit


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Intracellular pH (pHi) dynamics are a critical regulator of numerous cell behaviors, including cell migration, cell adhesion remodeling, and cell fate specification, yet the role of pHi dynamics during embryonic development in vivo remains largely unknown. The objective of this proposal is to address this gap by determining the function of pHi dynamics in the development of cranial neural crest, a highly conserved multipotent embryonic cell population, using zebrafish as a model. My findings have promise to reveal new insight on the cellular and molecular factors controlling craniofacial development, with important implications for human congenital diseases and tissue repair.

PI_NAMEs: CHOU-FREED, CAMBRIA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Behavior;Biology;Cell Adhesion;cell behavior;Cell Fate Control;cell fate specification;Cell membrane;cell motility;cell type;Cells;Cephalic;Chick;Chondrocytes;cofilin;craniofacial;Craniofacial Abnormalities;craniofacial development;Data;Defect;Development;Disease;Drosophila genus;Embryo;embryo cell;Embryonic Development;epithelial to mesenchymal transition;Exhibits;Focal Adhesion Kinase 1;forging;Future;Genetic;Genetic Transcription;Health;Human;Image;in vivo;innovation;insight;interest;Intestines;Ions;lens;live cell imaging;migration;Modeling;Molecular;Mouse Embryonic Stem Cells;Mus;Neural Crest;Neural Crest Cell;non-genetic;novel;Odontoblasts;Organism;Osteocytes;Ovarian Follicle;Paraxial Mesoderm;pharmacologic;Population;Proteins;protonation;ratiometric;Regulation;Reporter;Reporting;Role;sensor;single-cell RNA sequencing;Specific qualifier value;stem cells;System;Talin;Testing;Time;tissue repair;Tissues;vertebrate embryos;Zebrafish

PROJECT_TITLE: Intracellular pH Dynamics in Zebrafish Cranial Neural Crest Development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative: Recent studies highlight significant promise for multi-parametric MRI (MP-MRI) and Prostate Health Index (PHI) in biopsy-naïve men to help ~25% of men avoid unnecessary prostate biopsies (PBs) while missing few clinically significant prostate cancers (csPCas). However, there is a need to increase the number of men who can safely avoid PB and expand it to Black and Hispanic men. Hence, we will 1) recruit Black and Hispanic biopsy-naïve men with PSA from 4-10ng/ml into a comparative effectiveness study to identify strategies using PHI & MP-MRI alone, in series, and in parallel to develop race-specific biopsy strategies with PHI & MP-MRI, and 3) identify the most accurate and cost-effective biopsy strategy to detect csPCa and minimize unnecessary PBs.

PI_NAMEs: MURPHY, ADAM BRYANT (contact)

PROJECT_TERMS: Age;Asian population;Biological Assay;Biological Markers;Biopsy;black men;Black Populations;Black race;blind;Cancer Detection;cancer diagnosis;Clinical;clinically significant;cohort;Comedo;comparative effectiveness study;Complication;cost;Cost Analysis;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Cost Measures;cost-effectiveness ratio;Data;Detection;Diagnosis;diagnostic strategy;Diagnostic tests;digital;efficacy evaluation;Eligibility Determination;Enrollment;ethnic minority;Europe;experience;Extracapsular;Gleason Grade for Prostate Cancer;Goals;Health;high risk;Hispanic;Hispanic Populations;Histology;Image;imaging modality;improved;incremental cost-effectiveness;indexing;Information Systems;innovation;Invaded;Lesion;Lymphovascular;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methods;Minority;Minority Groups;Minority Men;Morbidity - disease rate;Necrosis;neuroendocrine differentiation;Noninfiltrating Intraductal Carcinoma;noninvasive diagnosis;novel diagnostics;Observational Study;overtreatment;Pathologic;perineural;Population;Predictive Value;prevent;prospective;Prostate;prostate biopsy;prostate cancer risk;Prostate-Specific Antigen;Protein Isoforms;PSA screening;Race;Radical Prostatectomy;recruit;Rectum;Reporting;Safety;safety assessment;Screening for Prostate Cancer;Series;Specificity;standard of care;Testing;tool;tumor;Validation

PROJECT_TITLE: Using Prostate Health Index and MRI in Combination for Cost-effectively Detecting High-Grade Prostate Cancer in Minorities

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health

PI_NAMEs: KNOTT, CHERYL L (contact)

PROJECT_TERMS: acronyms;African American;anti-cancer research;Area;Baltimore;biotin carboxyl carrier protein;Cancer Center;Cancer Control;cancer health disparity;cancer risk;Capital;Catchment Area;Cities;clinical trial enrollment;college;Communication;Communities;community advisory board;community engaged approach;community engagement;Community Outreach;community partnership;Comprehensive Cancer Center;County;Data;demographics;Doctor of Philosophy;Ensure;Ethnic Origin;evidence base;Evidence based intervention;experience;Future;Goals;Grant;Guidelines;Health;Health Policy;hormone related cancer;Income;Infrastructure;Investigational Therapies;Leadership;Malignant Neoplasms;Maryland;Molecular Biology;NCI Center for Cancer Research;Needs Assessment;neoplasm immunotherapy;Population;Population Sciences;Positioning Attribute;Process;programs;public education;Public Health;Race;recruit;Research;Research Priority;Risk Factors;socioeconomics;Strategic Planning;structural biology;Tobacco use;tumor immunology;tumor registry;United States;Universities;Work

PROJECT_TITLE: Community Outreach and Engagement


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Advancements in multimodal therapy for oral cavity and oropharyngeal (OC/OPC) cancers have improved survival outcomes beyond 5 years. However, most survivors will experience moderate-severe orodental sequelae that are inadequately monitored or managed given structural and informatics challenges precluding accurate orodental data collection. The proposed research aims to address implementation barriers to longitudinal patient- and provider-generated electronic data capture by developing practice-changing ontological systems and advanced computational models for treatment planning and assessment of outcomes.

PI_NAMEs: MORENO, AMY CATHERINE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Acute;Address;Adopted;Aftercare;Algorithms;Area;Assessment tool;Award;Cancer Patient;Cancer Survivor;care coordination;career development;Caring;Chronic;Clinic;Clinical;clinical data repository;Clinical Informatics;Clinical Management;clinical practice;Clinical Trials;Collection;Combined Modality Therapy;Communication;Computer Models;Computerized Medical Record;COVID-19 pandemic;craniofacial;Data;Data Aggregation;Data Collection;data exchange;data quality;Decision Making;Deglutition Disorders;Dental;Dental Care;Dental Informatics;Dental Records;Dentists;design;Development;Development Plans;Dimensions;Disease;disorder risk;electronic data;electronic health data;Electronic Health Record;Electronics;Evaluation;evidence base;experience;FAIR principles;formative assessment;Fostering;Future;Gingiva;Goals;Head and Neck Cancer;Health;High Prevalence;implementation barriers;implementation efforts;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation study;improved;Individual;individualized prevention;Informatics;innovation;interest;International;interoperability;Interruption;Intervention;Knowledge;learning strategy;Machine Learning;machine learning method;machine learning model;malignant oropharynx neoplasm;Mandible;Measures;Medical;Mentors;Mentorship;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;National Institute of Dental and Craniofacial Research;Nomenclature;novel;Oncologist;Ontology;Operative Surgical Procedures;Oral;Oral cavity;Oral health;Osteoradionecrosis;Outcome;Outcome Assessment;Patient Outcomes Assessments;Patients;Periodontal Diseases;personalized management;Population;Prediction of Response to Therapy;prevent;Prevention;Process;process improvement;project-based learning;prospective;Provider;Public Health;Quality of life;Radiation;Radiation Dose Unit;Radiation Oncologist;Radiation therapy;Readability;Reporting;Research;Research Design;Research Personnel;Risk;Risk Assessment;risk prediction;risk prediction model;Selection for Treatments;Series;Severities;Standardization;Statistical Methods;Structure;survival outcome;Survivors;survivorship;symptom management;Symptoms;System;Systems Development;Techniques;technology validation;Time;tool;Toxic effect;Training;Training Activity;treatment optimization;treatment planning;Trismus;United States;United States National Institutes of Health;Vendor;Work;Xerostomia

PROJECT_TITLE: Provider and Patient-generated Remote Oro-Dental Health Electronic Data Capture for Algorithmic Longitudinal Evaluation and Risk-Assessment (PROHEALER)


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Disability Research;Down Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: ROBERTS, TIMOTHY P (contact)

PROJECT_TERMS: Achievement;Address;Affect;Ally;Animal Model;autism spectrum disorder;Basal Ganglia;Behavior;Behavior assessment;Behavioral;Biological Markers;Biometry;Blinded;Brain;brain circuitry;Brain imaging;Brain Pathology;Calcium;Cells;Central Nervous System;Central Nervous System Diseases;Cerebral Palsy;Clinical Trials;cognitive function;Collection;Consult;Consultations;Country;Coupled;Data;Data Science;Data Set;data sharing;Databases;Development;Developmental Disabilities;Diagnostic;Disability research;Disease;DNA Sequence Alteration;Dyes;Electroencephalography;Eligibility Determination;Epilepsy;experimental analysis;Experimental Designs;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Generations;Genes;Genetic;Genetic Variation;Goals;Growth;Human;human model;Image;imaging study;improved;In Vitro;in vivo;indexing;induced pluripotent stem cell;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;Limbic System;Magnetic Resonance Imaging;Magnetoencephalography;Mediating;member;Meta-Analysis;Methodology;Methods;microscopic imaging;Mission;Modality;Modeling;Monitor;multi-photon;multimodality;multiphoton microscopy;Mus;Mutation;Neocortex;neural;neural circuit;neurochemistry;neuroimaging;neuronal circuitry;Neurons;neurophysiology;Neurosciences;novel;novel strategies;operation;patch clamp;Patients;Persons;Physiology;Population;power analysis;pre-clinical;Pre-Clinical Model;Procedures;prognostic;programs;protein expression;Protocols documentation;Quality Control;Research Design;Research Personnel;Research Support;response;Series;Services;Slice;Spectrum Analysis;Statistical Data Interpretation;stem cells;Stratification;structural imaging;Structure;Symptoms;Synapses;Techniques;Technology;temporal measurement;tissue culture;Tissues;Training;translational approach;translational therapeutics;voltage

PROJECT_TITLE: Neuroimaging & Neurocircuitry Core