ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE We identified a striking CD4 T cell population in the human gut that expressed high levels of cytotoxic mediators following exposure to enteric bacteria. Understanding the biology of these human gut cytotoxic CD4 T cells may inform strategies to curb mucosal HIV-1 replication, CD4 T cell death and HIV-1-associated immune activation and inflammation.

PI_NAMEs: SANTIAGO, MARIO LUIS;WILSON, CARA C. (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: acute infection;antiretroviral therapy;Apoptotic;Archives;Automobile Driving;Biological;Biology;Biopsy;Blood;CCR5 gene;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Death;Cell secretion;cell type;Cells;Cessation of life;Chronic;Circulation;cohort;commensal bacteria;comorbidity;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;Disease;dysbiosis;Enteral;Enterobacteriaceae;Epithelium;Exposure to;extracellular;Flow Cytometry;Frequencies;Functional disorder;Gastrointestinal tract structure;Genes;Gram-Negative Bacteria;Granzyme;Growth;gut microbiome;Gut Mucosa;HIV-1;Human;Human Biology;Immune;immune activation;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;insight;Knowledge;Lamina Propria;LAMP-1;Leaky Gut;Life Cycle Stages;Ligands;Link;Lymphoid;Lymphoid Tissue;Macaca mulatta;Mediating;Mediator;Memory;memory CD4 T lymphocyte;Microbe;microbial;microbial products;microbiome;Modeling;Molecular;Molecular Profiling;mortality;Mucositis;Mucous Membrane;mutant;novel marker;novel therapeutic intervention;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;perforin;peripheral blood;Persons;Phenotype;Plasma;Play;Population;Predisposition;Process;Production;Proliferating;Property;Reporting;Resolution;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;SIV;Source;survival prediction;systemic inflammatory response;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;transcription factor;transcriptome;transcriptomics;transmission process;Up-Regulation;Viral;Virus Diseases;Work

PROJECT_TITLE: Gut Cytotoxic CD4 T cells in HIV-1 Pathogenesis

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: MAGNESS, SCOTT T (contact)

PROJECT_TERMS: Award;Biology;Budgets;candidate selection;Conflict of Interest;Critiques;Data;design;Digestive System Disorders;Disease;Eligibility Determination;Exercise;Funding;Future;gastrointestinal;improved;Institution;Interdisciplinary Study;Investments;Liver diseases;Marketing;medical schools;member;Mission;Monitor;Online Systems;Oral;Pattern;Process;programs;Progress Reports;Research;Research Personnel;Research Project Grants;Structure;success;Topical application;United States National Institutes of Health;Writing

PROJECT_TITLE: Pilot and Feasibility Program


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative: Timing and temporal coding is important aspect of many brain systems and the underlying mechanisms play a role in numerous neurological disorders including dyslexia and autism. The cerebellum currently represents the best opportunity to brain understand mechanisms of timing. A better understanding of these processes could open doors for innovative treatment strategies for a variety of disorders.

PI_NAMEs: MAUK, MICHAEL D (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Animals;autism spectrum disorder;Axon;Back;Behavioral;Biological;Brain;Cells;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;Code;Conditioned Reflex;Coupling;Cytoplasmic Granules;Data;Data Analyses;Disease;Dyslexia;experimental study;Extinction;eyelid conditioning;Feedback;Golgi Apparatus;granule cell;Impairment;improved;innovation;large scale simulation;Learning;Methods;mossy fiber;Nervous System Disorder;neural;Neurons;Noise;optogenetics;Output;Physiology;Play;prevent;Process;Property;Recurrence;Resistance;response;Role;simulation;Synapses;synergism;System;Testing;theories;Time;time interval;time use;Training;treatment strategy

PROJECT_TITLE: Mechanisms of Timing and Temporal Coding

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: CORAL GABLES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: PROJECT NARRATIVE  We propose to develop a machine learning-based biomechanical analysis approach for rupture risk assessment of thoracic aortic aneurysm (TAA). This study will lead to a breakthrough in the fields of cardiovascular computational modeling and applied machine learning, provide new insights on how to better assess TAA risk, and reduce death by the silent and sudden killer of TAA disease.

PI_NAMEs: LIANG, LIANG  (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: 3-Dimensional;Adult;Aneurysm;Aorta;Aortic Aneurysm;biomechanical test;Biomechanics;Calibration;Cardiovascular system;Cause of Death;Cessation of life;Characteristics;Classification;Clinical;clinical application;Clinical Trials;Computer Models;Computer software;Consumption;cost;Data;Data Files;Data Set;deep neural network;density;Development;Devices;Diameter;Disease;Dissection;effectiveness testing;Evaluation Studies;Event;Face;Finite Element Analysis;Follow-Up Studies;General Population;Geometry;Goals;Healthcare Systems;high risk;Human;Image;improved;in vivo;indexing;individual patient;innovation;insight;Learning;Machine Learning;machine learning model;Magic;Measures;Medical Records;method development;mixed reality;Modeling;Natural Language Processing;Noise;novel;open source;Operative Surgical Procedures;Output;Patients;Performance;Population;Prevalence;prevent;Probability;Process;programs;real time model;reconstruction;repaired;Risk;Risk Assessment;Risk Reduction;Rupture;Ruptured thoracic aortic aneurysm;Shapes;Source;speech recognition;Stress;Symptoms;Techniques;Testing;Thoracic aorta;Thoracic Aortic Aneurysm;Time;Tissue Sample;Uncertainty;Validation;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Machine learning-based biomechanical analysis for thoracic aortic aneurysm rupture risk assessment

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Obesity;Substance Misuse

ORG_CITY: Los Angeles

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Fatty liver disease occurs in about 25% in the general population of the United States and as high as 70% in the obese population and those with Diabetes; and in individual who consume alcohol. With the increase in obesity rate and continued excessive drinking behavior in the US population, fatty liver is in line to become the leading cause of liver transplantation in the next 10 years. This project will study the molecular changes occurring with fatty liver using mouse models. We also designed an inhibitor to block the signal that we have discovered. We expect this inhibitor to exhibit therapeutic effect at treating fatty liver disease.

PI_NAMEs: STILES, BANGYAN  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: Address;Alcohol consumption;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Anabolism;Binding;Bioenergetics;Biogenesis;Biology;Cell Physiology;ChIP-seq;Chromatin;Chronic;Cirrhosis;Citric Acid Cycle;Complex;CREB1 gene;design;Development;Diabetes Mellitus;Diet;diet-induced obesity;Disease;drinking behavior;Dyslipidemias;Enzymes;estrogen-related receptor;Estrogens;Ethanol;Exhibits;Fatty Acids;Fatty Liver;fatty liver disease;feeding;Fibrosis;Functional disorder;functional outcomes;gain of function;Gene Expression Regulation;General Population;Genes;Genetic Models;Genetic Transcription;glucose metabolism;Goals;Heavy Drinking;High Fat Diet;In Vitro;in vivo;Individual;Inflammation;inhibitor;Insulin;Insulin Resistance;insulin signaling;Insulin-Like Growth Factor I;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Liver;Liver diseases;liver injury;liver transplantation;loss of function;Malignant neoplasm of liver;Mediating;member;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic syndrome;Metabolism;Mitochondria;Modeling;Modification;Molecular;mouse model;Mus;Mutation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;Nuclear Orphan Receptor;Nuclear Receptors;Nylons;obese person;Obesity;oxidation;Oxidative Phosphorylation;oxidized lipid;particle;Pathology;patient subsets;Patients;Phosphorylation;Physiological;PI3K/AKT;Play;Population;Precipitation;Production;promoter;Property;Protein Isoforms;Proto-Oncogene Proteins c-akt;Reactive Oxygen Species;Receptor Inhibition;Regulation;Reporting;Resistance;Role;Signal Pathway;Signal Transduction;small molecule;small molecule inhibitor;Steatohepatitis;System;Testing;Therapeutic Effect;therapeutic evaluation;transcription factor;Transcriptional Regulation;transcriptome sequencing;translational approach;Triglycerides;United States;Up-Regulation

PROJECT_TITLE: The Role of ERRa in liver lipid dysfunction and pathology

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: TEMPE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Alpha herpesviruses, like herpes simplex virus 1 (HSV-1), naturally infect the peripheral nervous system causing recurrent herpetic lesions, and can spread to the central nervous system causing encephalitis or may contribute to neurodegenerative disease. To spread to and within the nervous system, alpha herpesvirus particles must transport inside and then exit from infected cells, either non-neuronal cells, or neurons. The goal of this research is to better understand how HSV-1 spreads in the nervous system by investigating the molecular and cell biology of these processes.

PI_NAMEs: HOGUE, IAN B (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Agricultural Workers;Axon;Biological Models;Biological Process;Biology;Cell membrane;Cells;Cellular biology;Central Nervous System;Characteristics;China;Data;Development;Disease;Distal;druggable target;Encephalitis;Exhibits;Exocytosis;Family suidae;Fluorescence Microscopy;Focal Adhesions;gE protein;Genes;Goals;Golgi Apparatus;Herpesviridae;Herpesvirus 1;Human;human pathogen;Image;innovation;insight;Integration Host Factors;Intracellular Membranes;Intracellular Transport;Kinesin;knock-down;Knowledge;Lead;Lesion;live cell imaging;mad itch virus;Mediating;Methods;Microfluidics;Microtubule-Associated Protein 2;Microtubule-Associated Proteins;Microtubules;Modeling;Molecular;Molecular Biology;Motor;mutant;Mutation;Nervous System;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuronal cell body;Neurons;neuropathology;particle;pathogen;Pathway interactions;Peripheral;Peripheral Nervous System;Pharmaceutical Preparations;Phenotype;Population;Process;Reagent;recruit;Recurrence;Reporting;Research;Role;Secretory Vesicles;Sensory;Site;Sorting;System;Tissues;trafficking;Vaccines;Vesicle;Viral;Viral Encephalitis;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Zoonoses

PROJECT_TITLE: Molecular and cellular mechanisms of HSV-1 assembly and egress

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: STRATFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: Project Narrative DNA is constantly damaged in cells and must be repaired to maintain cellular health. This application examines protein complexes that form during a DNA repair process called uracil base excision repair. Uracil base excision repair regulates several biological processes including adaptive immunity, the infectivity of certain viruses, and the efficacy of specific chemotherapeutics.

PI_NAMEs: WEISER, BRIAN PATRICK (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: adaptive immunity;Architecture;Area;base;Base Excision Repairs;Binding;Biochemical;Biological Assay;Biological Process;Cell Nucleus;Cells;chemotherapeutic agent;Colorectal;Complex;CRISPR/Cas technology;crosslink;Data;design;Development;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Maintenance;DNA Repair;DNA replication fork;DNA Structure;ds-DNA;Engineering;Escherichia coli;Excision;experimental study;Genetic Recombination;Health;HT29 Cells;Human;In Vitro;in vivo;Individual;interest;Knock-out;Ligation;Methodology;Methods;Modeling;Molecular;Multiprotein Complexes;mutant;Nature;Nuclear;Pathway interactions;Process;Proliferating Cell Nuclear Antigen;protein complex;Protein Engineering;protein function;protein purification;Proteins;Proteomics;Reaction;Recombinants;Repair Complex;repaired;replication factor A;Replication-Associated Process;Role;scaffold;Single-Stranded DNA;Site;Stress;Structure;success;Surface;synthetic construct;System;Telomere Maintenance;Testing;Therapeutic;Uracil;uracil-DNA glycosylase;Virus

PROJECT_TITLE: RPA-Directed DNA Repair Mechanisms

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Neurological disease impacts the health of nearly 100 million Americans yearly, making it essential to increase our understanding of how neurons achieve their proper shape and function. Many neurodevelopmental and degenerative diseases arise from perturbing the microtubule cytoskeleton. Through our studies, we will gain new insight into mechanisms that regulate the balance of stable and dynamic microtubules at synapses; in the future, this knowledge may be leveraged to advance innovative treatments of diseases associated with microtubule dysfunction.

PI_NAMEs: WILDONGER, JILL C (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acetylation;Affect;alpha Tubulin;American;Biological Assay;Biological Models;biophysical analysis;biophysical techniques;Biophysics;Cells;Communication;Coupled;Cytoskeleton;Data;Degenerative Disorder;Development;dimer;Disease;Drosophila genus;Drug Targeting;Electrophysiology (science);Ensure;Equilibrium;experimental study;fly;Functional disorder;Future;genetic analysis;genetic approach;genetic manipulation;Goals;Growth;Health;In Vitro;in vivo;Individual;innovation;insight;Knowledge;Microtubules;Modeling;Molecular;Morphogenesis;Morphology;Motor Neurons;mutant;Mutate;Mutation;nanoscale;Nervous System Disorder;Neurodevelopmental Disorder;Neuromuscular Junction;Neurons;new growth;novel;Paper;Phase;Physiology;Play;Plus End of the Microtubule;Population;Positioning Attribute;Post-Translational Protein Processing;Presynaptic Terminals;Property;quantitative imaging;Role;Shapes;single molecule;Site;Structure;Synapses;Testing;transmission process;Tubulin

PROJECT_TITLE: Mechanistic analysis of microtubule dynamics and stability in neurons

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE OVERALL Research supported through the WU DDRCC has and will continue to have a profound impact on understanding the pathophysiology of digestive disease and the role of host-environment interactions. The WU DDRCC also promotes scientific collaboration and synergies that ultimately will identify new therapeutic opportunities with the potential for rapid translation into clinical trials for patients with digestive diseases.

PI_NAMEs: DAVIDSON, NICHOLAS O. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Animal Model;Appointment;Award;base;Basic Science;biobank;career;career development;Clinical;Clinical Trials;Collaborations;Communities;cost;cost effective;Development;Digestive System Disorders;Direct Costs;Discipline;Disease;Educational workshop;Environment;Epithelium;Faculty;Fostering;Functional disorder;Funding;Future;Genetic Services;Goals;Health;Homeostasis;host-microbe interactions;Image;Imaging technology;Inflammation;Infrastructure;Institution;Interdisciplinary Study;interest;Investigation;Investments;Journals;Malignant Neoplasms;member;Mentors;Metabolic;Midwestern United States;Mission;mouse genetics;Mucosal Immunity;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel therapeutics;Nutrient;Organoids;paligenosis;Paper;Patient Care;Patients;Peer Review;Postdoctoral Fellow;Productivity;programs;Publications;Research;Research Personnel;Research Support;Resources;response;Role;Services;Signal Transduction;stem cells;synergism;Technology;technology development;Tissues;Translational Research;Translations;Underrepresented Minority;Universities;Visit;Washington

PROJECT_TITLE: Host-environment interactions in the pathophysiology of digestive disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Lung;Prevention;Rare Diseases;Sleep Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PUBLIC HEALTH RELEVANCE/PROJECT NARRATIVE Sleep apnea impacts up to 4% of adults and is associated with an increased risk of cardiovascular disease, stroke, diabetes, and cancer. The goal of this project is to determine how chronic intermittent hypoxia, a feature of sleep apnea, impacts the bone marrow of patients with the blood cancer multiple myeloma. The results from the studies proposed here will provide critical information that may be used to develop clinical trials aimed at improving outcomes for patients with this incurable cancer and will lay the groundwork for future studies in human patients.

PI_NAMEs: TOMASSON, MICHAEL H (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Adult;American;Animals;Automobile Driving;Bone Marrow;Bone Marrow Neoplasms;cardiovascular disorder risk;case control;Cells;Chemoresistance;chemotherapy;Chronic;Clinical;Clinical Research;Clinical Trials;Continuous Positive Airway Pressure;Databases;design;Development;Diabetes Mellitus;Diagnosis;Disease;Disease remission;Dissection;DNA Sequence Alteration;Drug resistance;Engraftment;Epidemiology;Equipment and supply inventories;Exogenous Factors;experience;falls;Future;Gene Expression;genetic signature;Goals;Heart Diseases;Hematologic Neoplasms;Hematopoietic Neoplasms;Home;Hour;Human;human data;human subject;Hypoxia;Hypoxia Pathway;Immunity;improved outcome;In complete remission;Infiltration;Inflammation;innovation;insight;Light;Link;Literature;Macrophage;Malignant - descriptor;Malignant Neoplasms;mortality;Multiple Myeloma;Mus;Newly Diagnosed;Outcome;Oxygen;Patient-Focused Outcomes;Patients;Periodicity;Physiology;Plasma Cells;Population;pre-clinical;predictive marker;premalignant;Probability;Process;Progressive Disease;public health relevance;Quality of life;Recording of previous events;Relapse;Resistance;response;Risk Factors;RNA;screening;Severities;Signal Pathway;Sleep;Sleep Apnea Syndromes;Soil;Stroke;Surface;Symptoms;Syndrome;Testing;Therapeutic;therapy resistant;Time;transcriptome sequencing;Translating;Transplantation;treatment response;tumor;Tumor Promotion;Tumor-associated macrophages;Work

PROJECT_TITLE: Sleep Disordered Breathing as a Targetable Risk Factor in Multiple Myeloma

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Administrator;Animal Model;Award;Awareness;base;career;career development;Collaborations;Communication;Digestive System Disorders;Direct Costs;Environment;Evolution;Faculty;Feedback;Functional disorder;Funding;Future;genome sciences;Goals;Growth;Individual;Infrastructure;Institution;Interdisciplinary Study;interest;International;Intramural Research;Investments;Journals;Leadership;meetings;member;Mentorship;Midwestern United States;Mission;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Organoids;programs;recruit;Research;Resources;response;Review Committee;sabbatical;Scientist;Services;symposium;synergism;Systems Biology;Technology;Underrepresented Minority;Visit;web site

PROJECT_TITLE: Administrative and Resource Core


NIH_SPENDING_CATS: Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition

PI_NAMEs: SAENZ, JOSE BERNARDO (contact)

PROJECT_TERMS: Academic skills;Adult;Area;career;career development;Career Mobility;Chicago;Childhood;Collaborations;Communities;Development;Diabetes Mellitus;Digestive System Disorders;Educational workshop;Electronics;Environment;Event;Faculty;Functional disorder;Gastroenterology;Goals;Immunology;Infrastructure;interest;Interest Group;Journals;meetings;member;Michigan;Microbiology;Midwestern United States;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;Online Systems;Pathology;Pediatrics;posters;programs;Research;Research Personnel;Role;Rotation;sabbatical;senior faculty;Series;skills;symposium;Training Support;Underrepresented Minority;Visit

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Depression is a recurrent illness and even with successful antidepressant treatment, older adults with late-life depression are at high risk of recurrence. However, neurobiological processes that contribute to vulnerability to recurrence are poorly understood, limiting our ability to target mechanisms in prevention studies. The current study will elucidate neurobiological contributors to recurrence, examine the interrelationship between recurrence and cognitive decline, and provide data on the predictive utility of clinical monitoring in older adults.

PI_NAMEs: TAYLOR, WARREN D (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;actigraphy;Affect;Affective;aging brain;anti-depressive agents;Behavioral;Clinical;clinical practice;Cognitive;cognitive function;cognitive load;cognitive performance;Data;Depressed mood;depressive symptoms;Development;Disease remission;Early Diagnosis;Ecological momentary assessment;Elderly;Environmental Monitoring;Equilibrium;executive function;Exhibits;experience;Functional Magnetic Resonance Imaging;Future;geriatric depression;Goals;high risk;Homeostasis;Impaired cognition;Individual;Laboratories;Longitudinal Studies;Measures;Mental Depression;Monitor;mood symptom;Moods;negative affect;network models;neural;neural network;Neurobiology;neuroimaging;Noise;older adult;Participant;Performance;Predictive Factor;predictive marker;Prevention;Process;prospective;Recording of previous events;Recovery;Recurrence;recurrent depression;Regulation;Reporting;Residual state;Risk;Risk Marker;rumination;Severities;Signal Transduction;single episode major depressive disorder;Site;Sleep;Stress;stress reactivity;Subgroup;Symptoms;Testing;Therapeutic Intervention;Time;Translating;young adult

PROJECT_TITLE: 1/3-Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-life Depression (Rembrandt)


PI_NAMEs: MINER, JEFFREY H (contact)

PROJECT_TERMS: Address;Animal Model;Basic Science;Biological;cell growth;Cell Line;Cells;clinical practice;Complex;Consultations;cost effective;CRISPR/Cas technology;Culture Media;Derivation procedure;Development;Differentiation and Growth;Digestive System Disorders;Disease;DNA;embryonic stem cell;Environment;Epithelial Cells;Equipment;Fertilization in Vitro;Functional disorder;Funding;gastrointestinal epithelium;gastrointestinal system;gene function;Generations;germ free condition;Germ-Free;Gnotobiotic;Goals;Growth;Health;Human;Human Cell Line;Human Resources;Image;Infrastructure;Injections;Institution;Interdisciplinary Study;Knock-in Mouse;Knock-out;knockin animal;Mediating;member;Microinjections;Mission;Modeling;Monitor;monolayer;Mouse Cell Line;mouse genetics;mouse model;Mus;novel;Nucleic Acids;Organoids;overexpression;Pathogenesis;preclinical study;Publications;Reagent;Reporter;Research;Research Personnel;Resources;response;Services;Surveys;Systems Development;Technical Expertise;Technology;transcription activator-like effector nucleases;Transgenes;Transgenic Organisms;Translations;Universities;vector;Washington;Withdrawal;zygote

PROJECT_TITLE: Precision Animal Models and Organoids Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Digestive Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: RUBIN, DEBORAH C. (contact)

PROJECT_TERMS: 3-Dimensional;Animal Experimentation;animal tissue;Antibodies;Award;cell type;Cells;cellular imaging;Clinical Sciences;Computer software;cost effective;Cryoelectron Microscopy;Digestive System Disorders;Environment;Equipment;Fee-for-Service Plans;fluorescence microscope;Functional disorder;Funding;Gastrointestinal tract structure;Goals;Hematoxylin and Eosin Staining Method;high resolution imaging;Histologic;Human;Human Resources;human tissue;Image;Image Analysis;imaging facilities;Imaging technology;in vivo;in vivo imaging;Institution;Interdisciplinary Study;investigator training;Investments;Light;Light Microscope;Liver;member;Microscope;microscopic imaging;Microscopy;Mission;Morphology;Organ;Paraffin;Procedures;programs;Publications;quantitative imaging;Reporting;Research;Research Personnel;Scanning Electron Microscopy;Services;Slide;spatial relationship;Stains;Surveys;Technology;Tissue Embedding;Tissue imaging;tissue processing;Tissues;tool;Training;Transmission Electron Microscopy;transmission process;two photon microscopy;two-photon;ultra high resolution;Universities;Visible Radiation;Visualization software;Washington;X ray microscopy

PROJECT_TITLE: Advanced Imaging and Tissue Analysis Core


PI_NAMEs: NEWBERRY, RODNEY D (contact)

PROJECT_TERMS: Acceleration;biobank;Biomedical Research;Categories;Child;Clinical;Clinical Data;clinical translation;Collection;Consent;Consent Forms;cost;cost effective;Data;Data Collection;Digestive System Disorders;DNA;Enrollment;Environment;Feces;Functional disorder;Funding;Gene Expression;Genetic;Genotype;Guidelines;high throughput analysis;Human;Human Resources;Infrastructure;Institution;Institutional Review Boards;Interdisciplinary Study;Link;material transfer agreement;member;Metadata;Metagenomics;microbial;Mission;Observational Study;Outcome;Patient Recruitments;Patients;Peer Review;Process;prospective;Prospective Studies;Protocols documentation;Publications;Qualifying;Research;Research Personnel;Research Project Grants;Resources;Retrospective Studies;RNA;Running;sample collection;Services;Specimen;Training;Translational Research;United States;Universities;Washington;Writing

PROJECT_TITLE: BIOBANK Core


NIH_SPENDING_CATS: Digestive Diseases

PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROJECT_TERMS: Award;base;Cardiology;career;career development;Cells;Clinical;Communicable Diseases;Communities;Creativeness;Critiques;Data;Developmental Biology;Digestive System Disorders;Direct Costs;Discipline of obstetrics;Electronic Mail;Endocrinology;Environment;Extramural Activities;Faculty;Functional disorder;Funding;Genetic;Goals;Grant;Growth and Development function;Gynecology;Hematology;Hepatology;Immunology;interactive feedback;Interdisciplinary Study;Investments;K-Series Research Career Programs;Medicine;meetings;Methods;Microbe;Mission;Nature;nutrition;Oncology;Pathology;Pediatrics;Peer Review;Play;Process;professor;programs;Publications;Publishing;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Rheumatology;Role;Running;Science;Telephone;Universities;Washington;Work;Writing

PROJECT_TITLE: Pilot & Feasibility Program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Pediatric

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sustained activation of the innate immune system during periods of rapid growth leads to growth failure, whether in children suffering from chronic enteropathogen infection or in the model organism Drosophila melanogaster. In young children and in fruit fly larvae, innate immune signaling leads to insufficient circulating levels of homologous growth-promoting hormones: liver-derived insulin-like growth factor-1 and fat body-derived Drosophila insulin-like peptide 6. How infection impairs the endocrine control of growth is poorly understood, and the studies proposed here will use genetic approaches in flies and mammals to identify molecular mechanisms that link innate immune signaling with disrupted endocrine function and growth impairment.

PI_NAMEs: BLAND, MICHELLE L (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Address;Animals;Binding;Campylobacter;Campylobacter infection;Campylobacter jejuni;Child;Childhood;ChIP-seq;Chronic;Chronic Childhood Arthritis;chronic infection;cognitive development;cognitive function;cognitive performance;Complication;Crohn's disease;cytokine;Cytokine Signaling;Data;Diarrhea;Disease;Drosophila genus;Drosophila melanogaster;early childhood;Endocrine;Endocrine disruption;Endotoxins;enteric infection;enteric pathogen;Escherichia coli;Event;Exhibits;Failure;Fat Body;fly;forward genetics;Functional disorder;gastrointestinal;Genes;Genetic;genetic approach;Genetic Models;Genetic Screening;Genetic Transcription;Genomic approach;Genomics;Growth;Growth Hormone Signaling Pathway;Hepatocyte;Heterozygote;Homologous Gene;hormonal signals;hormone regulation;hormone resistance;Hormones;Immune;Immune response;Immune signaling;Impaired cognition;Impairment;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innate immune function;Innate Immune System;Insulin-Like Growth Factor I;insulin-like peptide;Interleukins;Laboratories;Larva;Learning Disabilities;Link;Liver;loss of function mutation;Mammals;Messenger RNA;model organism;Molecular;Mus;Mutation;NF-kappa B;novel therapeutics;Organ;Orthologous Gene;pathogen;Pathway interactions;Patients;pharmacologic;postnatal;Prevention;Principal Investigator;Production;promoter;rapid growth;receptor;Receptor Signaling;recruit;Regulation;response;Shigella;Signal Pathway;Signal Transduction;Site;Somatotropin;stem;Tissues;TLR4 gene;Toll-like receptors;Transcript;transcriptomics;whole genome;Work

PROJECT_TITLE: Signaling mechanisms linking infection, endocrine dysfunction, and growth failure

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care;Sexually Transmitted Infections

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In the U.S., youth ages 15-24 years comprise only 13% of the U.S. population, but represent 21% of incident HIV and approximately 50% of incident STI cases, underscoring the critical need for innovative research to address these co-occurring epidemics. Conducting the proposed research within the structure of a mentored, career development framework, with focused training in behavioral intervention adaptation and development, implementation science, and clinical and pragmatic trial design and management will help establish my career as an independent clinician-scientist dedicated to HIV and STI prevention in adolescents and young adults. The program of applied research and associated training delineated in this award will focus on the adaptation (Aim 1), implementation optimization (Aim 2), and testing (Aim 3) of a PrEP-inclusive health coaching intervention to reduce HIV and STI incidence among adolescents and young adults, which aims to be scalable across primary care contexts.

PI_NAMEs: WOOD, SARAH MARIAN (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 18 year old;acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adolescent and Young Adult;adolescent HIV prevention;adolescent sexual health;Advisory Committees;Affect;Age;aged;AIDS prevention;Applied Research;Award;behavior change;Behavior Therapy;Behavioral;Behavioral Model;biobehavior;care delivery;career;career development;Childhood;Clinical Trials;Clinical Trials Design;comorbidity;comparative efficacy;comparison intervention;Complement;Consolidated Framework for Implementation Research;Counseling;Data;Dedications;Development;Diagnosis;effectiveness-implementation randomized trial;effectiveness/implementation trial;emtricitabine;Epidemic;evidence base;Focus Groups;Goals;Guidelines;Health;Health Care Costs;health care delivery;Health Services;Health system;high risk;high-risk adolescents;HIV;HIV Infections;Hybrids;implementation facilitators;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;infection rate;innovation;Intervention;intervention effect;Interview;Licensure;Measurement;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Modeling;motivated behavior;motivational enhancement therapy;National Institute of Mental Health;patient oriented;Patients;pediatric health outcomes;Population;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;pre-exposure prophylaxis;prevent;Prevention;Prevention approach;prevention service;preventive intervention;Preventive service;Primary Care;primary care provider;Process;programs;Provider;Public Health;Qualitative Methods;Randomized, Controlled Trials;Recommendation;Recording of previous events;Research;Research Methodology;Research Personnel;Risk;Risk Reduction;scale up;Science;Scientist;screening;Self Efficacy;Self Management;Sexual Health;sexual health intervention;Sexually Transmitted Diseases;skills;standard of care;STI prevention;Structure;Techniques;Tenofovir;Testing;theories;therapy development;Time;tool;Training;Training Programs;trial design;United States;United States Food and Drug Administration;uptake;Wood material;Youth

PROJECT_TITLE: Health Coaching to Improve Comprehensive HIV and Sexually Transmitted Infection Prevention in Adolescent Primary Care

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cancer

ORG_CITY: DALLAS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Cancer cells are addicted to glucose but only to secrete the majority as lactate (also known as aerobic glycolysis or Warburg effect), thereby creating an inhospitable glucose-poor and lactate-rich microenvironment that would otherwise be lethal to most cells. This application is designed to mechanistically investigate how lactate regulates cancer cell glucose utilization and to assess the therapeutic potential of targeting cancer lactate oxidation. The results from this study will provide knowledge in the regulation of central carbon metabolism and insight into the targeting lactate oxidation as a cancer therapy.

PI_NAMEs: CAI, XIN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute;aerobic glycolysis;Anti-diabetic Drugs;ATP Synthesis Pathway;Biochemical;Biochemistry;Bioenergetics;Biological Assay;Biomass;cancer cell;Cancer cell line;cancer therapy;Carbon;career development;Cell Proliferation;Cells;Chemicals;Citric Acid Cycle;Clinical;clinical training;Complex;Consumption;Data;design;Development Plans;Doctor of Philosophy;Electron Transport;Environment;Enzymes;Equilibrium;extracellular;FDA approved;Genetic;Glucose;Glycolysis;Goals;Growth;Image;imaging modality;In Vitro;in vivo;inhibitor;insight;Knock-out;Knowledge;Laboratory Research;liquid chromatography mass spectrometry;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;medical schools;Memorial Sloan-Kettering Cancer Center;Mentorship;Metabolic;Metabolism;metabolomics;Methods;Mitochondria;novel;Nutrient;Organelles;oxidation;Oxidative Phosphorylation;patient derived xenograft model;Permeability;Phenformin;Phosphorylation Inhibition;Physicians;Postdoctoral Fellow;Production;Proliferating;Proteins;Pyruvate;Regulation;Reporter;Research;research and development;response;Scientist;Serum;skills;Source;Therapeutic;Training;tumor;tumor metabolism;tumor microenvironment;Universities;Warburg Effect

PROJECT_TITLE: Mechanistically Dissecting Glycolysis Regulation by Lactate and Its Therapeutic Potential in Cancer


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Alzheimer's disease is a neurodegenerative disease with devastating personal, familial, societal and economic burdens for which there is currently no effective means of prevention or treatment. In this proposal, we will use genetic analyses to systematically infer causal relationships between health, lifestyle, psychosocial, disease and molecular (gene expression, protein levels, metabolites) traits for Alzheimer’s disease outcomes. Completion of this proposal has the potential to identify novel causes of Alzheimer’s disease that have not been previously captured using traditional epidemiological approaches and to prioritize factors for immediate intervention to reduce risk now.

PI_NAMEs: ANDREWS, SHEA J (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Advisory Committees;Age;aging population;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Applied Skills;Award;Big Data Methods;biobank;Biological;Blood Vessels;Cerebrovascular Trauma;cohort;Dementia;Development;Diabetes Mellitus;Disease;Disease Outcome;Disease Progression;disorder prevention;Economic Burden;Education;Educational workshop;Elderly;Electronic Health Record;endophenotype;Epidemiology;epidemiology study;Ethics;Etiology;experience;Exposure to;Feedback;Foundations;Gene Expression;Genetic;genetic analysis;genetic epidemiology;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genomics;Genotype;Health;hearing impairment;Hippocampus;Hypertension;Incidence;Individual;Intervention;Knowledge;Leadership;Life Style;lifestyle factors;lifestyle intervention;Literature;Mendelian randomization;Mental Depression;Mentors;Methodology;Methods;Minority Groups;modifiable risk;Molecular;Nature;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;novel;Obesity;Observational epidemiology;offspring;Outcome;Parents;Pathogenesis;Persons;Phase;phenome;Phenotype;physical inactivity;polygenic risk score;population stratification;Populations at Risk;prevent;Prevention;programs;Proteins;Proxy;psychosocial;Random Allocation;Randomized, Controlled Trials;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Senile Plaques;sex;skills;Smoking;Social isolation;Societies;Subgroup;successful intervention;symposium;tau Proteins;tau-1;Techniques;Testing;Therapeutic Intervention;Training;Training Programs;trait;Woman

PROJECT_TITLE: Elucidating the causal associations underlying Alzheimer's disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BIRMINGHAM

ORG_NAME: BIRMINGHAM VA MEDICAL CENTER

ORG_STATE: AL

PHR: NARRATIVE Center-based programs to promote regular physical activity among patients with peripheral artery disease (PAD) are frequently not available and when offered are associated with significant barriers for patients. Home based programs may improve access to these effective programs among Veterans. However, which delivery methods are most effective is not known. This study will use a SMART design to compare two delivery methods for a home-based walking program tailored to Veterans with PAD.

PI_NAMEs: JACKSON, ELIZABETH A. (contact);MYERS, JONATHAN N.

PROJECT_TERMS: Address;Adult;adverse outcome;Age;American;Amputation;Area;arm;Arteries;Behavior;Blood flow;Blood Vessels;cardiovascular disorder risk;Cardiovascular system;Cessation of life;claudication;comorbidity;comparative efficacy;Diabetes Mellitus;Diagnosis;Disease Management;Disease Outcome;efficacy evaluation;Ethnic Origin;Evaluation;Event;Exercise;exercise physiologist;exercise program;experience;functional disability;Goals;Guidelines;health related quality of life;Home;Hypertension;Improve Access;improved;innovation;interest;Intervention;Knowledge;limb amputation;Limb structure;Measurement;Measures;Methods;Minority Groups;Mission;mortality;Nonpharmacologic Therapy;novel;Online Systems;Pain;Pain Free;pain reduction;Participant;patient-level barriers;Patients;Peripheral;Peripheral arterial disease;Persons;Physical activity;physical conditioning;Physical Function;primary outcome;programs;Protocols documentation;Provider;Publishing;Race;Randomized;Recommendation;Rehabilitation therapy;remote delivery;Reporting;Research;Research Design;Residencies;response;revascularization;Risk;Risk Factors;Risk Reduction;Rural;secondary outcome;Sequential Multiple Assignment Randomized Trial;Severities;Site;Stents;Surveys;Symptoms;telehealth;Translating;treadmill;treatment as usual;trial design;Veterans;video delivery;Visit;Walking;walking program

PROJECT_TITLE: Telehealth delivered home-based walking for vets with Peripheral Artery Disease (TREK-PAD)

STUDY_SECTION_NAME: Chronic Medical Conditions & Aging[RRD6]


ORG_CITY: PHOENIX

ORG_NAME: PHOENIX VA HEALTH CARE SYSTEM

PHR: Project Narrative  Traumatic brain injury leaves Veterans with persistent neurological symptoms, specifically cognitive impairments, that require treatment of the chronic injured brain. Using an experimental model of spatial navigation cognitive rehabilitation, cognitive function is preserved in diffuse brain-injured rats when administered early after injury. Efficacy is lost when treatment is delayed, as would be necessary for Veterans. In preliminary results, psychoplastogens – drugs that induce neuroplasticity – preceding cognitive rehabilitation rescue cognitive function in the chronic period of TBI. The proposed research investigates psychoplastogen drug concentrations that induce a neuroplastic state, demonstrate the therapeutic efficacy of drug treatment preceding rehabilitation, and quantify the neuroplastic changes in cells, synapses, and receptors. The proposed research is relevant to the VA mission, because the results would provide evidence for effective treatment strategies for chronic cognitive impairment.

PI_NAMEs: LIFSHITZ, JONATHAN  (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Affective;Age;Amygdaloid structure;Anxiety;Attention;axon injury;Basal Ganglia;Behavioral;Brain;Brain Injuries;Brain region;Brain-Derived Neurotrophic Factor;Cell Culture Techniques;Cell Physiology;Cells;Chemicals;Chronic;Chronic Brain Injury;Clinical;Cognition;Cognitive deficits;cognitive function;cognitive performance;cognitive recovery;cognitive rehabilitation;cognitive task;cohort;comparison control;Data;Deafferentation procedure;density;Diffuse;Diffuse Brain Injury;Disease;Dose;Drug Exposure;Dyes;effective therapy;Environment;Exhibits;Experimental Models;Female;Floor;Fluorescent Dyes;forest;Functional disorder;Functional Magnetic Resonance Imaging;gene gun;group intervention;Hallucinogens;Head;Hippocampus;Impaired cognition;Impairment;improved;Inflammation;injured;Injury;Intervention;Ketamine;Label;Laboratories;Lead;lipophilicity;Liquid substance;male;Measures;Memory;Memory impairment;Mental Depression;Mental disorders;Mission;Morbidity - disease rate;neural circuit;Neural Pathways;neural patterning;Neurologic;Neurologic Dysfunctions;Neurologic Signs;Neurologic Symptoms;Neurological outcome;Neuronal Plasticity;Neurons;novel;novel strategies;object recognition;Pathway interactions;Percussion;Persons;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Post-Traumatic Stress Disorders;preservation;Presynaptic Terminals;prevent;Property;prospective;Psilocybin;Rattus;receptor;Recording of previous events;regenerative;Regenerative response;Regimen;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;response;Rest;Rodent;Saline;Series;serotonin receptor;Serotonin Receptor 5-HT2A;sex;Structure;Survivors;Synapses;Testing;Therapeutic;Therapeutic Intervention;Time;Traumatic Brain Injury;Treatment Efficacy;treatment strategy;Vascular Permeabilities;Vertebral column;Veterans;way finding;Western Blotting

PROJECT_TITLE: Psychoplastogens to make the injured brain receptive to cognitive rehabilitation during the chronic period ofTBI

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Statins are the most cost-effective medications to lower cholesterol and cardiovascular disease (CVD) risk. However, many patients at high-risk for CVD do not accept or adhere to statins. This gap in patient’s use of statins limits the full impact of these effective medications resulting in higher cholesterol levels and CVD risk. The main barriers to using statins are patients’ perceived lack of benefit, excess risk of statin toxicity as well as their misperceptions of their CVD risk. Statin pharmacogenomic testing – an application of precision medicine – is a readily available, feasible, and inexpensive intervention that addresses this barrier by using genetic testing to identify the nearly 1 out of 2 patients with enhanced benefit and/or reduced risk of statin toxicity or increased risk for CVD. By communicating statin pharmacogenomic test results to Veterans at high- risk for CVD not taking statin therapy, we aim to improve patients’ perceptions of their risk of CVD and statins and, in turn, their acceptance of and adherence to statins to reduce their cholesterol levels and CVD risk.

PI_NAMEs: BRAVATA, DAWN MARIE;VOORA, DEEPAK  (contact)

PROJECT_TERMS: Address;Adherence;Affect;Appointment;Atherosclerosis;atherosclerosis risk;Belief;Benefits and Risks;budget impact;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cholesterol;cholesterol control;Clinical;clinically significant;Communication;contextual factors;cost effective;cost effectiveness;cost estimate;Data;data warehouse;Disclosure;Disease;Dissemination and Implementation;Dose;Economic Factors;Economic Models;Education;Effectiveness;Electronic Health Record;electronic medical record tool;Eligibility Determination;Enrollment;Ensure;experience;future implementation;Genetic Risk;genetic testing;genetic variant;Genomic medicine;Genomics;Goals;Guidelines;Health;health belief;Health Care Costs;Health system;Healthcare;high risk;implementation determinants;implementation evaluation;improved;Infrastructure;innovation;Intervention;intervention cost;intervention delivery;Laboratories;LDL Cholesterol Lipoproteins;Measures;Mediator;Methodology;Modeling;Musculoskeletal;Outcome;Participant;Patient Preferences;Patients;Perception;Pharmaceutical Preparations;Pharmacogenomics;Pharmacy facility;precision medicine;prevent;Prevention;Primary Care;primary care patient;primary care practice;primary care provider;primary outcome;Process;programs;Protocols documentation;Provider;Quality of Care;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Priority;Risk;risk perception;Safety;secondary outcome;shared decision making;side effect;Test Result;Testing;tool;Toxic effect;Translating;Treatment Effectiveness;uptake;Veterans;Work

PROJECT_TITLE: Reducing Veterans' Risk of Atherosclerotic Cardiovascular Disease Through Pharmacogenomics Informed Statin Prescribing

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ORG_CITY: BUFFALO

ORG_NAME: VA WESTERN NEW YORK HEALTHCARE SYSTEM

ORG_STATE: NY

PHR: Mild traumatic brain injury (mTBI), also known as concussion, is a common injury sustained by Veterans. While most individuals who sustain mTBI experience a complete recovery within several weeks of injury, many Veterans with history of mTBI report frequent and long-lasting neurobehavioral complaints and functional impairment. Though research suggests that these outcomes are strongly influenced by co-occurring conditions such as post-traumatic stress disorder, depression, and chronic pain, evidence-based interventions capable of addressing this wide array of concerns are lacking. This study seeks to address this gap by evaluating the effectiveness of a brief and flexible behavioral health treatment (Problem-Solving Training for Concussion, or PST-Concussion), which was designed to be delivered by generalist providers working in VA primary care settings. If PST-Concussion is shown to be effective, this skills-focused intervention may help improve Veterans’ recovery experience following mTBI.

PI_NAMEs: KING, PAUL R. (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;arm;Attention;behavioral health;Brain Concussion;career development;Caring;Chronic;chronic pain;Clinical;Clinical Management;Clinical Practice Guideline;Clinical Trials Cooperative Group;clinically significant;Cognitive;Cognitive deficits;cognitive function;Cognitive Therapy;cohort;comorbidity;Consensus;cost;Data;design;Digit structure;disability;Distress;Education;Effectiveness;effectiveness evaluation;effectiveness testing;eligible participant;Enrollment;Environment;Equipment and supply inventories;Evaluation;Evidence based intervention;experience;feasibility trial;flexibility;follow-up;Frustration;Functional impairment;functional improvement;functional outcomes;General Practitioners;Goals;Health;Health Care Costs;Health Services Accessibility;improved;Individual;Injury;insight;Intervention;Interview;Investments;K-Series Research Career Programs;Long term disability;Managed Care;Measures;medical specialties;Memory;Mental Depression;Mental Health;Mental Health Services;Methods;mild traumatic brain injury;motivational enhancement therapy;multilevel analysis;neurobehavioral;Neurobehavioral Manifestations;Neurocognitive;Neurocognitive Deficit;Outcome;Participant;Patient Self-Report;Patients;Population;population health;Post-Traumatic Stress Disorders;Practice Guidelines;Primary Care;primary care setting;primary outcome;Problem Solving;Procedures;Process;prospective;Protocols documentation;Provider;psychological distress;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recovery;rehabilitation research;Rehabilitation therapy;Relaxation Therapy;Reporting;Research;research clinical testing;Resources;Risk;Sampling;service member;skills;Symptoms;telehealth;Testing;therapy design;Time;Training;treatment as usual;treatment effect;trend;Verbal Learning;Veterans;Veterans Health Administration;Work;World Health Organization

PROJECT_TITLE: Problem-Solving Training for Concussion (PST-Concussion):  A Brief, Skills-Focused Intervention to Improve Functional Outcomes in Veterans with mTBI and Co-occurring Mental Health Symptoms

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


FUNDING_MECHANISM: OTHERS

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Studies in animal models show that the antiretroviral medications used to manage or prevent HIV can harm hearing and magnify the risk of ototoxic hearing loss by damaging mitochondrial DNA. Yet there has been no investigation of the impact of these drugs on human hearing. This proposed research is relevant to Veterans’ health because it will clarify the genetic and auditory effects of antiretroviral exposure on Veterans receiving healthcare from the Veterans Health Administration (VA), the largest single provider of HIV care in the United States. Continued use of daily antiretroviral therapy is a cornerstone of VA’s strategies for HIV prevention and management and the US Department of Health and Human Service’s goal to end the HIV epidemic by 2030. Once regimens with the greatest risk of ototoxicity and genotoxicity have been identified, alternative regimens for HIV management and prevention can be implemented that support these public health goals while preserving hearing.

PI_NAMEs: DEBACKER, JAMES RILEY (contact)

PROJECT_TERMS: Acquired Deafness;Adherence;AIDS prevention;Aminoglycoside Antibiotics;aminoglycoside-induced ototoxicity;Aminoglycosides;Animal Model;Anti-Retroviral Agents;antiretroviral therapy;Audiology;Auditory;Auditory Physiology;auditory processing;Automobile Driving;Award;Blood;blood-brain barrier crossing;career;Caring;Central Auditory Diseases;Central Nervous System;Classification;Clinical;Clinical Markers;Cochlea;Cognition;cohort;Combined Modality Therapy;Complex;Counseling;Data;Dedications;Development;DNA Damage;Drug usage;Effectiveness;Epidemic;Epidemiology;experimental study;Exposure to;Frequencies;Functional disorder;Genetic;Genetic Determinism;genetic information;Genetic Markers;Genetic Screening;genotoxicity;Goals;Health;health goals;Healthcare;Hearing;hearing impairment;hearing preservation;Hearing problem;hearing range;hearing screening;high risk;HIV;HIV Infections;HIV/AIDS;Human;Impaired cognition;Impairment;Individual;individual patient;Intervention;Investigation;Knowledge;Link;machine learning prediction;Measures;Medication Management;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;Modeling;Mus;Mutation;Needs Assessment;Nervous System Trauma;non-compliance;ototoxicity;Outcomes Research;Patient risk;Patients;Pattern;Penetration;Performance;Peripheral;Persons;Pharmaceutical Preparations;Population;Populations at Risk;pre-exposure prophylaxis;preclinical study;predictive modeling;prevent;Prevention;programs;prophylactic;Prophylactic treatment;Prospective cohort;Provider;Public Health;Publications;Quality of life;Recommendation;recruit;Regimen;Reporting;Research;Retrospective cohort study;Risk;Risk Factors;risk stratification;Scientist;Sensorineural Hearing Loss;Services;side effect;Site;social;Speed;Statistical Models;Testing;Tissues;Training;Treatment Side Effects;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;uptake;Variant;Veterans;Veterans Health Administration;Viral;Well in self;Work

PROJECT_TITLE: Ototoxicity-associated Mutations Following Antiretroviral Exposure

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ADMINISTERING_IC: DC

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE The brain prioritizes information processing to the most pressing stimuli at a given time. The barn owl, a specialist in sound localization studied for several decades, has a well-described circuit dedicated to identifying and localizing the most salient sounds in the environment. Previous study has shown that this circuit utilizes gamma oscillations in space coding. This unique circuit provides the opportunity to assess the role of oscillations in encoding perception of salient sounds in circumstances of many competing sounds, which may have future implications for understanding potential bases of deficits in stimulus detection in noisy environments caused by hearing loss and the optimization of hearing aids.

PI_NAMEs: BAE, ANDREA J (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Role of brain oscillations in midbrain and forebrain networks supporting stimulus selection in the sound localization pathway of barn owls


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Infertility;Prevention;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Vector control is the primary tool to prevent vector-borne diseases such as dengue, Zika and malaria. This project aims to study the sex determinate and sexually dimorphic genes in the dengue vector, Aedes aegypti to develop new genetic vector control technologies to suppress disease vector populations. These resulting technologies will provide insight into the biology of this important vector and may lead to the development of a more cost effective and efficacious strategy to prevent vector-borne disease.

PI_NAMEs: AKBARI, OMAR SULTAN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Alleles;Automobile Driving;Biological Assay;Biology;Candidate Disease Gene;combinatorial;comparative genomics;Contracts;cost;cost effective;CRISPR/Cas technology;Culicidae;Data;Dengue;Dengue Fever;design;Development;Disease Vectors;disorder prevention;Drosophila melanogaster;efficacy evaluation;egg;Embryo;endonuclease;Engineering;Ensure;Environment;Essential Genes;Evaluation;Exhibits;experimental study;Female;Fertility;Fertility Study;fitness;Frequencies;Friends;functional genomics;Gene Components;Gene Targeting;Generations;Genes;Genetic;Genetic Vectors;Genome;Guide RNA;Homing;improved;Infection;Infection prevention;innovation;Insecta;insight;Knock-out;Legal;Life;Location;loss of function;Malaria;male;male fertility;Male Sterility;Masculine;mathematical model;Mechanics;Methods;mosaic loss;Mosaicism;Mosquito Control;new technology;novel;offspring;Pharmaceutical Preparations;Phenotype;Population;Population Control;Population Genetics;Populations at Risk;prevent;Production;programs;Reproducibility;screening;Series;sex;sex determination;sexual dimorphism;Site;Stable Populations;sterile insect technique;Sterility;success;System;Technology;technology/technique;tool;transcriptomics;transgene expression;Transgenes;Transgenic Organisms;Vaccines;vector;vector control;vector mosquito;Vector-transmitted infectious disease;Wolbachia;Work;Yellow Fever;ZIKA;zika fever

PROJECT_TITLE: Precision guided SIT for the control of vector-borne disease

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Alcohol related hospitalizations have been on the rise throughout the COVID-19 pandemic and intestinal barrier function has been shown to play a key role in the development of alcohol induced liver injury. Our proposed studies will reveal a very new cell-type specific mechanism by which intestinal epithelial and immune cells cross-talk in terms of signaling of a very important protein called Aryl Hydrocarbon Receptor (AhR) to restore the damage caused by alcohol on the gut and the liver.

PI_NAMEs: CALZADILLA, NATHAN  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Address;Affect;Alanine Transaminase;alcohol effect;alcohol response;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Attention;Attenuated;attenuation;Biological Assay;Cell Line;Cell Maintenance;Cell Physiology;cell type;Cells;Circulation;Coculture Techniques;Colon;COVID-19 pandemic;CYP1A1 gene;Data;delta receptors;Development;dietary;Dissection;Endotoxemia;Endotoxins;Epithelial Cells;Epithelium;Ethanol;experimental study;feeding;Functional disorder;gastrointestinal;Genes;gut microbes;gut-liver axis;Hospitalization;Immune;Impairment;improved;in vivo;in vivo Model;Indoles;Inflammation;Interleukin-10;interleukin-22;Intervention;intestinal barrier;intestinal epithelium;intestinal injury;Intestinal permeability;Intestines;Investigation;Knock-out;Knockout Mice;Large Intestine;Ligands;Lipopolysaccharides;Liver;liver injury;Maintenance;Measures;Mediating;microbial;minority communities;Minority Groups;Modeling;Molecular;mouse model;Mucous Membrane;Mus;new therapeutic target;novel;Pathway interactions;Permeability;Plasma;Play;Population;protective effect;protein expression;Proteins;Receptor Activation;receptor function;Receptor Signaling;Reporter;Reproducibility;response;Role;Sales;Serum;Sex Differences;Signal Pathway;Signal Transduction;Small Intestines;Source;statistics;Testing;Tight Junctions;tool;Training;training opportunity;transcription factor;Travel;Tryptophan;Variant;Wild Type Mouse;Work;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: The roles of intestinal epithelial AhR in alcohol-induced barrier dysfunction and liver injury


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Vector-Borne Diseases;West Nile Virus

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: This project aims to uncover specific host factors and responses that contribute to viral tropism and patterns of neuroinflammation. Through a combination of whole mount and single molecule imaging, sequencing, and classical virology exploiting both murine and human models, the immune reaction to flaviviral encephalitis will be profiled at the single cell level and interrogated as to how it is modulated by autocrine, paracrine, and endocrine immune signaling. This will shed light on the pathogenesis of encephalitic flaviviruses and serve as a blueprint for understanding neuroinflammation for a variety of non- viral CNS conditions.

PI_NAMEs: RICE, CHARLES M (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adverse reactions;Affect;Antibodies;Area;Astrocytes;Attenuated;Autoantibodies;autocrine;Blocking Antibodies;Brain;Brain region;Cell Culture Techniques;cell type;Cells;Cellular Tropism;Central Nervous System;Central Nervous System Diseases;Central Nervous System Infections;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Complex;cytokine;Data;Data Set;Disease;Encephalitis;Encephalomyelitis;Endocrine;Environment;Event;Exhibits;Flavivirus;Flavivirus Infections;Fluorescent in Situ Hybridization;Frequencies;Gene Expression;Healthcare Systems;Human;human induced pluripotent stem cells;human model;IFNAR1 gene;Image;Immune;Immune response;Immune signaling;Immunity;Immunologic Factors;immunomodulatory therapies;immunoreaction;improved;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;Infection;Inflammation;Inflammatory Response;Innate Immune Response;Integration Host Factors;Interferon Type I;Interferons;Invaded;Kinetics;Knock-out;knockout animal;Knockout Mice;Knowledge;Life;Light;Literature;Lyme Neuroborreliosis;Maps;Mediating;Microglia;Microscopy;Modeling;molecular imaging;mouse model;Mus;neural;neural model;Neuroglia;neuroinflammation;Neurons;neutralizing antibody;novel therapeutic intervention;Nuclear RNA;Outcome;paracrine;Pathogenesis;Pathogenicity;Pattern;Peripheral;permissiveness;Persons;Play;Population;prevent;Process;Property;Research;Research Personnel;Resistance;resistance factors;Resolution;response;Role;Route;severe COVID-19;Shapes;Signal Transduction;single molecule;single nucleus RNA-sequencing;Spinal Cord;stem cell model;Stress;System;Techniques;Testing;Time;tissue tropism;Tissues;tool;transcriptome sequencing;transcriptomics;Traumatic Brain Injury;Tropism;tumor-immune system interactions;Viral;Viral Antigens;Viral Encephalitis;Viral Pathogenesis;virology;Virus;Virus Diseases;Virus Replication;Visualization;West Nile Encephalitis;West Nile viral infection;West Nile virus;Yellow Fever Vaccine

PROJECT_TITLE: A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: NARRATIVE Age-related macular degeneration (AMD) is a common blinding disease characterized by biochemical changes and atrophy of the blood vessels that supply the retina. Understanding how genes contribute to the dysfunction of these blood vessels will enable the creation of better treatments for AMD. In this research program we will study how an important gene affects the behavior of human blood vessel cells and will identify additional genes that distinguish between early AMD, “dry” AMD and “wet” AMD.

PI_NAMEs: MULLINS, ROBERT FOSTER (contact);SCHEETZ, TODD E;TUCKER, BUDD A

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Affect;Age related macular degeneration;Atrophic;Behavior;Biochemical;Blindness;Blood capillaries;Blood Vessels;Categories;Cells;Cessation of life;Choroid;Choroidal Neovascularization;Communities;Complement;Complement Membrane Attack Complex;complement system;Complex;Cytolysis;Data;Disease;Drusen;Endothelial Cells;Extracellular Matrix Degradation;Exudative age-related macular degeneration;Eye;Functional disorder;Genes;geographic atrophy;Health;Histologic;Human;human RNA sequencing;ICAM1 gene;Imaging Techniques;Immunofluorescence Immunologic;In Situ Hybridization;In Vitro;Individual;induced pluripotent stem cell;Inflammatory;Injury;insight;knowledge translation;Label;Lentivirus;macula;Mediating;migration;Molecular;Molecular Profiling;Mus;new technology;Nonexudative age-related macular degeneration;normal aging;PECAM1 gene;Phenotype;Photoreceptors;Population;Preparation;preservation;Process;programs;Proliferating;Public Health;Research;Resolution;Retina;retinal damage;single-cell RNA sequencing;Small Interfering RNA;Structure of retinal pigment epithelium;Thick;transcriptome;transcriptomics

PROJECT_TITLE: Molecular Studies of the Choriocapillaris in AMD

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project aims to clarify how certain genes act to cause a form of uveitis (inflammation within the eye) which is common in many parts of the world as well as in Americans of Hispanic, East Asian, Middle Eastern and South European descent: Behcet's Eye Disease (BED). This form of uveitis often leads to blindness if not treated, and current treatments can fail or cause serious side effects. Successful completion of this project will help design better medications for BED and similar diseases which pose large public health problems such as psoriasis, certain types of arthritis and bowel inflammation as well as other forms of uveitis.

PI_NAMEs: NOWATZKY, JOHANNES  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Affect;Age;Aminopeptidase;Ankylosing spondylitis;anterior chamber;Antigen Presentation;Antigens;Aqueous Humor;Arthritis;Autoimmunity;Behcet Syndrome;Behcet's eye disease;Binding;Biological;Biological Models;birdshot chorioretinitis;Blindness;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Immunity;Clonal Expansion;Clonality;Clone Cells;Code;cohort;computerized tools;CRISPR/Cas technology;Data;Data Analyses;design;Disease;East Asian;Effector Cell;effector T cell;Endoplasmic Reticulum;European;Event;experience;Eye;Eye diseases;Flow Cytometry;Frequencies;Genes;Genetic Epistasis;Genetic Polymorphism;genome editing;Goals;gut inflammation;Haplotypes;high risk;Hispanic Americans;Histocompatibility Antigens Class I;HLA Antigens;Immune;immune function;Immune response;Immune System Diseases;Immunogenetics;Inflammation;Inflammatory;Inflammatory Bowel Diseases;International;Knock-out;Knowledge;Link;Liquid substance;Literature;Mediating;meetings;Memory;Methods;Middle Eastern;Outcome;Pathogenesis;Pathway interactions;Patients;Peptides;Peripheral;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Population;Prevalence;Proteins;Psoriasis;Public Health;Publishing;rational design;receptor;receptor function;Research;response;Risk;risk variant;Role;Shapes;side effect;single-cell RNA sequencing;Spondylitis;Systemic disease;T cell response;T-Lymphocyte;targeted treatment;TCR Activation;Testing;therapy design;transcriptomics;Uveitis;Variant

PROJECT_TITLE: Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  During infancy and throughout the first years of life, touch powerfully contributes to infant-parent interactions that are fundamental for social development. Abnormalities in tactile perception are prevalent features in individuals with autism spectrum disorders (ASD), exacerbating core social communication deficits. Understanding the circuit mechanisms through which early somatosensory neuronal networks are modulated for social significance will provide crucial information on the establishment of attachment, as well as a framework that can help refine therapeutic directions and intervention efforts for treating symptoms of ASD.

PI_NAMEs: CHE, ALICIA YUE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Auditory;autism symptoms;barrel cortex;Behavior;Behavior assessment;Behavioral;Behavioral Assay;Brain;Calcium;career;Clinical;Cognitive;cohort;Communication;Consultations;design;Development;Disinhibition;Electrophysiology (science);experience;Faculty;Foundations;Funding;Future;Genetic;Goals;hippocampal pyramidal neuron;Image;Imaging Techniques;in vivo;individuals with autism spectrum disorder;infancy;Infant;insight;Interneurons;Intervention;Investigation;Life;Link;mature animal;Measures;Mediating;meetings;Membrane;Mental disorders;Mentors;Methods;Modality;Monitor;Motor;mouse genetics;Neonatal;neonatal mice;neonatal period;neurobiological mechanism;Neurodevelopmental Disorder;neuronal circuitry;Neurons;Neuropeptides;neuroregulation;Noise;optogenetics;Oxytocin;Oxytocin Receptor;Parents;Perception;Play;Positioning Attribute;postnatal;Process;Prosencephalon;Psychophysics;pup;recruit;Research;Research Personnel;response;Role;Secure;Sensory;sensory input;sensory stimulus;serotonin receptor;Shapes;Signal Transduction;skills;Slice;social;Social Behavior;social communication;social deficits;Social Development;Social Environment;Social Interaction;Solid;somatosensory;Stimulus;Surveys;symptom treatment;Synapses;Synaptic Transmission;System;Tactile;Techniques;temporal measurement;Testing;Thalamic structure;Therapeutic;Time;tool;Touch sensation;Training;two-photon;Vibrissae;Visual;Whole-Cell Recordings;Work

PROJECT_TITLE: Maturation of Somatosensory Circuits for Social Behaviors

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Hepatitis;Hepatitis - A;Infectious Diseases;Liver Disease;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Hepatitis A virus (HAV) is a common cause of enterically-transmitted viral hepatitis globally that has re-emerged in recent years within the United States causing multiple disease outbreaks and >140 deaths. This project investigates the crucial role played by distinct host lipid species in the HAV lifecycle, and how these lipids contribute to the ability of the virus to enter and infect cells and to produce new infectious progeny virus released from cells cloaked in host membranes. The proposed research addresses a neglected facet of the biology of this important human pathogen, and may suggest novel approaches to treatment and prevention of infections by this and other viruses with similar lifecycles.

PI_NAMEs: LEMON, STANLEY M. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acute Hepatitis;Address;Antibodies;Binding;Biological Assay;Biology;Blood;Capsid;Capsid Proteins;Carbohydrates;Carbon;Cells;Ceramide glucosyltransferase;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Cytolysis;Data;dihydroceramide desaturase;Disease Outbreaks;Endocytosis;Enteral;Enzymes;exosome;experimental study;extracellular vesicles;Family Picornaviridae;Fatty Acids;Gangliosides;Genes;Genetic;Genetic Screening;Genetic Transcription;genome-wide;Glucosylceramides;Glycoproteins;Glycosphingolipids;Hepatitis A;Hepatitis A Virus;Hepatocyte;Hepatovirus;Human;human pathogen;Infection;Infection prevention;Integration Host Factors;Knock-out;Laboratories;late endosome;Life Cycle Stages;lipid metabolism;lipidomics;Lipids;Maps;Measures;member;Membrane;neglect;novel strategies;Organelles;pathogenic virus;permissiveness;Persons;Play;Production;Productivity;Proteins;Replicon;Reproducibility;Research;Research Personnel;RNA;Role;Sialic Acids;Site;Sphingolipids;Structure;Surface;Tail;Testing;thermostability;trafficking;Transfection;United States;Very Long Chain Fatty Acid;Viral;Viral hepatitis;viral RNA;viral transmission;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Critical Lipid Species in the Hepatovirus Lifecycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal mortality and morbidity, particularly for Black women who are at greatest risk of poor outcomes. Neighborhood greenspace has been associated with improved cardiovascular (CV) outcomes in the general population, but few studies have evaluated the relationship between greenspace and the development of HDP and chronic hypertension (cHTN) after pregnancy. The objective of this proposal is to leverage both an observational and experimental study design to evaluate the impact of neighborhood greenspace and a greenspace intervention on HDP and cHTN in a cohort of 92,000 pregnant patients, as well as to quantify the extent to which greenspace contributes to Black-white HDP and cHTN disparities.

PI_NAMEs: BURRIS, HEATHER HERSON;SOUTH, EUGENIA C (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Adult;adverse pregnancy outcome;Affect;Area;Birth;Birth Rate;Black race;black women;black/white disparity;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caucasians;Chronic;cohort;comparison control;Data;data repository;Data Set;Development;Disease;disparities in morbidity;Disparity;disparity reduction;Dose;Environment;experimental study;Feeling;General Population;Green space;Health;health inequalities;Health Promotion;Healthcare Systems;Heart Rate;high risk;Hispanic Women;Hypertension;improved;Incidence;Individual;Individual Adjustment;Intervention;intervention cost;Investigation;Link;Logistic Regressions;maternal morbidity;Maternal Mortality;Measures;Mediating;Mediation;Mental Depression;Methods;Modeling;Neighborhoods;Observational Study;Outcome;outcome disparities;Participant;Patients;perinatal outcomes;Philadelphia;Policy Maker;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;pregnant;Premature Birth;prevent;Provider;Quasi-experiment;Race;racial disparity;Randomized, Controlled Trials;repository;Research Design;residential segregation;response;Risk;Risk Reduction;Role;Shapes;social;Source;Survival Analysis;Time;tool;Trees;United States;violent crime;White Women;Woman;Women's mortality

PROJECT_TITLE: The Role of Neighborhood Greenspace in reducing Risk of Hypertensive Disorders of Pregnancy, Chronic Hypertension, and Racial Disparities in Maternal Morbidity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Digestive Diseases;Microbiome;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Despite nutritional interventions and attempts to improve sanitation, undernutrition remains a pressing global health problem that persists across generations. Environmental enteric dysfunction (EED) is a small intestinal inflammatory enteropathy that has been postulated to contribute to the pathogenesis of undernutrition in children and its poor long-term outcomes; however, the etiology of EED is poorly understood. The goal of this proposal is to investigate the hypothesis that a perturbed small intestinal microbiota contributes to the pathophysiology of EED in children and in women of reproductive age by integrating gnotobiotic mouse models and multi-omic technologies in order to identify microbial targets and ultimately develop therapies towards undernutrition.

PI_NAMEs: KAO, CLARA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 5 year old;Adult;Adult Children;Adult women;Affect;Age;aptamer;Area;aspirate;Bacteria;bacterial community;Bangladesh;Bangladeshi;Biological;Biopsy;Body mass index;candidate identification;Cells;Child;Childhood;Chronic;Chronology;Clinical;cohort;Collection;Communities;community transmission;Consumption;Development;Diet;Dietary Intervention;Disease;DNA;Duodenum;Enteral;Epithelium;Esophagogastroduodenoscopy;Etiology;Experimental Models;experimental study;Exposure to;Family;fecal microbiota;Female of child bearing age;follow-up;Functional disorder;Gene Expression Profiling;Generations;Germ-Free;global health;Gnotobiotic;Goals;Growth;gut microbiota;Histologic;Histopathology;Immune;Immune response;Immunoassay;Impairment;improved;Incidence;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;insight;intergenerational;Intervention;Intestinal Content;Intestines;Lamina Propria;Length;Locales;long-term sequelae;Malnutrition;Measurement;member;microbial;microbial community;microbiota;microorganism;Modeling;Mothers;mouse model;Mucous Membrane;multiple omics;Mus;Nature;neurodevelopment;novel;Nuclear RNA;offspring;Outcome;Output;Participant;Pathogenesis;Pathology;Phenotype;Plasma;Plasma Proteins;Play;pre-clinical;Pre-Clinical Model;Preclinical Testing;prevent;Prevention;Protein Deficiency;Proteins;Proteome;pup;recruit;reproductive;Research Personnel;Ribosomal DNA;Risk;Role;Sampling;Sanitation;Shotgun Sequencing;Slum;Small Intestines;stool sample;Structure;Surface;Technology;technology platform;Testing;Therapeutic;therapeutic target;therapy development;Time;Tissues;transcriptome sequencing;transmission process;Villus;Woman;World Health Organization

PROJECT_TITLE: CHARACTERIZATION OF THE ROLE OF THE SMALL INTESTINAL MICROBIOTA IN THE PATHOGENESIS OF ENVIRONMENTAL ENTERIC DYSFUNCTION IN UNDERNOURISHED CHILDREN AND MOTHERS


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases;Wound Healing and Care

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Narrative  Acute respiratory distress syndrome (ARDS), rheumatoid arthritis, and venous, pressure, and diabetic ulcers are associated with excessive numbers of white blood cells called neutrophils entering a tissue. Being able to repel neutrophils from a tissue, and/or augment the effect of a neutrophil repellent, could be useful as a therapeutic. Relatively little is known about cell repellents, and we propose to study these mechanisms using the advantages of a simple model system, and then use this information to help develop therapeutics.

PI_NAMEs: GOMER, RICHARD H (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Agonist;aspirate;Biochemistry;Biological Models;cell motility;Cells;Cessation of life;Clinic;Clinical;CT2584 HMS;decubitus ulcer;Development;diabetic ulcer;Dictyostelium;Dipeptidyl-Peptidase IV;Disease;Drug Interactions;Eukaryotic Cell;Feedback;Female;G-Protein-Coupled Receptors;Genetic;Genetic Screening;Human;Inflammation;Innate Immune System;insight;Leukocytes;Lung;lung injury;male;Mediating;men;Modeling;Molecular;mouse model;Movement;Mus;mutant;neutrophil;PAR-2 Receptor;Pathway interactions;Patients;Play;Property;Protein Secretion;receptor;Resolution;Rheumatoid Arthritis;Role;Sex Differences;side effect;Signal Transduction Pathway;small molecule;Source;Testing;Therapeutic;Tissues;Varicose Ulcer;Woman;Work

PROJECT_TITLE: Elucidation of a Eukaryotic Chemorepulsion Mechanism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Dietary Supplements;Digestive Diseases;Liver Disease;Nutrition

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent condition effecting about 30% of Americans and costing the U.S about $103 billion per year, with no FDA approved treatments beyond lifestyle alterations. Mammalian target of rapamycin complex 2 (mTORC2) is emerging as a major metabolic hub and its activation has been linked to NAFLD in mice due to its role in regulating lipid metabolism in response to high fat diets, however, the major dietary supplements attributed to NAFLD prevalence are carbohydrates, especially fructose. In this proposal, I will investigate the role of hepatic mTORC2 in regulating carbohydrate derived acetyl-CoA production and utilization in NAFLD, using a combination of molecular biology, metabolomic, and proteomic approaches.

PI_NAMEs: HALEY, JOHN ANTHONY (contact)

PROJECT_TERMS: Ablation;Acetates;Acetyl Coenzyme A;Acute;Address;Affect;American;ATP Citrate (pro-S)-Lyase;Auxins;Brown Fat;carbohydrate metabolism;Carbohydrates;Cells;Cirrhosis;clinically relevant;Communication;Complex;Consumption;cost;Cytoplasm;Developing Countries;Diet;dietary supplements;Dose;Endocrine;Enzymes;Fasting;Fatty acid glycerol esters;Fatty Liver;FDA approved;fighting;flexibility;FRAP1 gene;Fructose;Gluconeogenesis;Glucose;Glycogen;Goals;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;Human;Impairment;Life Style;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver transplantation;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Modernization;Molecular Biology;Mus;neglect;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Nuclear;Nutrient;Obesity;Organ;Pathogenesis;Pathologic;Pathology;Pathway interactions;Persons;Phosphorylation;Plants;Prevalence;Primary carcinoma of the liver cells;Process;Production;protective effect;Proteomics;Regulation;response;Role;Signal Transduction;standard of care;sugar;System;Testing;Time;Work

PROJECT_TITLE: Elucidating the role of hepatic mTORC2 as a key regulator of carbohydrate metabolism in non-alcoholic fatty liver disease


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE Increased DNA damage and DNA damage response (DDR) activation is well-documented in cardiovascular disease (CVD) and heart failure in humans, but no current treatment strategies exist to target this population. Here, applying cutting-edge optical, biological, and bioelectrical tools we will map cardiac tissue cell-cell communication and electrophysiology in response to stochastic endogenous DNA damage. Deeper understanding of the regulatory network that mediates the genotoxic stress response in the cardiac tissue will suggest preventive strategies and therapeutic interventions to reduce public health burden.

PI_NAMEs: COHEN-KARNI, TZAHI  (contact);GURKAR, ADITI U

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Age;Anthracycline;Architecture;autocrine;Biochemical;bioelectricity;Biological;biological adaptation to stress;Calcium;Cancer Survivor;Cardiac;Cardiac health;Cardiac Myocytes;cardiac tissue engineering;Cardiovascular Diseases;cardiovascular disorder risk;Cell Aging;Cell Communication;Cell Culture Techniques;cell dimension;cell type;Cells;Coculture Techniques;comparison control;CRISPR/Cas technology;Crista ampullaris;Cultured Cells;Data;Data Science;design;Deterioration;Dilated Cardiomyopathy;Disease;Dissection;DNA;DNA Damage;DNA mapping;DNA Repair Endonuclease;Electrophysiology (science);ERCC1 gene;Event;Exhibits;Fibroblasts;Frequencies;Functional disorder;Genes;Genotoxic Stress;genotoxicity;heart damage;heart dimension/size;Heart Diseases;heart electrical activity;Heart failure;heart function;Human;human induced pluripotent stem cells;imaging modality;in vivo;induced pluripotent stem cell technology;inhibitor;innovation;insight;Intervention;Investigation;Ionizing radiation;Life;Link;Lipids;live cell imaging;Machine Learning;Maps;Measurement;Mediating;Membrane Potentials;Metabolic;millisecond;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Mus;Myocardial dysfunction;Myocardium;Myofibrils;nanofabrication;Nature;novel;novel therapeutic intervention;Nuclear;Optics;Organoids;Oxidative Stress;paracrine;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Prevention strategy;Primary idiopathic dilated cardiomyopathy;Production;Public Health;Qualifying;Reactive Oxygen Species;repaired;response;Role;senescence;senescent cell;senolytics;sensor;Series;Source;spatiotemporal;Specificity;spheroids;Surface;System;Target Populations;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;TP53 gene;Treatment Protocols;treatment strategy;two-dimensional;Work

PROJECT_TITLE: Mapping the cell specific DNA damage-induced molecular and bioelectrical responses in the 3D cardiac unit

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Kidney Disease;Lymphatic Research

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because kidney function affects diseases from diabetes to hypertension to osteoporosis. Kidney inflammation resulting from acute kidney injury is often a slippery slope towards incurable chronic kidney disease. The proposed research of identifying the mechanisms by which renal lymphatic vessel density protects against kidney inflammation and preserves kidney function is thus highly relevant to the NIH’s mission of developing knowledge to improve human health outcomes.

PI_NAMEs: RUTKOWSKI, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;American;animal data;Antigens;Bilateral;Biological Markers;Biological Models;Biology;Cells;Characteristics;Child;Chronic;chronic inflammatory disease;Chronic Kidney Failure;Cisplatin;Clinical;Closure by clamp;cytokine;Data;density;Diabetes Mellitus;Disease;Disease Progression;Epidemic;Excretory function;Exhibits;Fibrosis;Functional disorder;Future;Genetic;Genetic Models;Genetic Techniques;Goals;Health;healthcare burden;high salt diet;Homeostasis;Human;Hypertension;Immune;Immune response;Impairment;improved;Inflammation;Inflammatory;Inflammatory Response;Injury;injury recovery;Injury to Kidney;innovation;inorganic phosphate;interstitial;Ischemia;Kidney;Kidney Diseases;kidney preservation;Knowledge;Liquid substance;Lymphangiogenesis;Lymphatic;lymphatic vasculature;lymphatic vessel;macromolecule;Medicare;Metabolism;Minerals;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nephrotoxicity;novel;Osteoporosis;Outcome;overexpression;Pathogenesis;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Physiological;Physiology;Positioning Attribute;Pre-Clinical Model;pressure;prevent;Prognosis;Proteinuria;Public Health;Publishing;Regulation;remediation;Renal function;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Resistance;response;response to injury;Risk;Risk Factors;Role;Route;Severities;Sodium;solute;statistics;success;Testing;Therapeutic;tissue injury;Tissues;United States National Institutes of Health;Up-Regulation;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor D;Vascular Endothelial Growth Factor Receptor-3;Work

PROJECT_TITLE: Lymphatics and lymphangiogenesis in kidney function and inflammation

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Pediatric brain cancer survivors are at increased risk for poor social connectedness, diminished health-related quality of life and reduced psychological well-being, though the associations between these factors and the underlying mechanisms impacting the trajectory of social connectedness are poorly understood. The proposed project will use an accelerated longitudinal design to compare the social connectedness and well-being among survivors of malignant and non-malignant brain tumors, determine the influence of social connectedness on health and well-being, and evaluate risk and mechanistic factors for social connectedness. Findings from this project will significantly advance our understanding of the importance of social connectedness in pediatric brain cancer survivorship and inform the development of effective interventions that target mechanistic factors.

PI_NAMEs: HOCKING, MATTHEW C. (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Behavior;biopsychosocial;Body Composition;Body mass index;Brain;Brain Injuries;Brain Neoplasms;Cancer Survivor;Cancer Survivorship;cancer therapy;Cerebellar Pilocytic Astrocytoma;Childhood Brain Neoplasm;Childhood Malignant Brain Tumor;Clinical;Cognitive;cohort;Craniopharyngioma;Data;Development;Diagnosis;effective intervention;Endocrine;Exhibits;experience;Face Processing;Family;Fatigue;Friends;Friendships;Goals;Health;health related quality of life;Hearing;Hormones;Impairment;improved;information processing;innovation;interest;Intervention;irradiation;Knowledge;Late Effects;longitudinal design;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Marriage;Measurement;Measures;Medical;Medulloblastoma;Mental Health;Metabolic;Methods;Modeling;Morbidity - disease rate;neurobiological mechanism;neuroimaging marker;Neurologic;Neurosecretory Systems;Non-Malignant;novel;Operative Surgical Procedures;Outcome;Oxytocin;Participant;Pediatric Hospitals;peer;Personal Satisfaction;Philadelphia;Physical therapy;Pilocytic Astrocytoma;Populations at Risk;Process;prospective;Radiation;recruit;Research;Rest;Risk;Risk Factors;Schools;Secondary to;sex;side effect;social;social attention;Social Behavior;social factors;Social Functioning;social influence;Social isolation;Somatotropin;Survivors;Testing;Thyroid Gland;Time;tumor;Visit;Well in self;Youth

PROJECT_TITLE: Social Connectedness in Pediatric Brain Cancer Survivors


ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Current treatment options for blood in the brain (intracerebral hemorrhage) are not optimal and overall success rates are not as high as desired. By developing an MR compatible robot, we aim to improve the treatment process and offer new options for these patients.

PI_NAMEs: CHEN, YUE ;CLEARY, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Address;Algorithms;animal data;aspirate;Biological;Blood;Blood coagulation;Brain;Brain Injuries;brain parenchyma;brain tissue;Cannulas;Cerebral hemisphere hemorrhage;Cerebrum;Cessation of life;Clinical;Data;design;Devices;Diffusion Magnetic Resonance Imaging;Edema;Electronics;Ensure;Environment;Excision;Feedback;Freedom;Goals;Hematoma;Hemorrhage;Hemostatic function;Heterogeneity;Hour;image guided;Image-Guided Surgery;Impairment;improved;Inflammation;Infusion procedures;innovation;Intervention;Lobar;Magnetic Resonance;Magnetic Resonance Imaging;Medical;Medical center;minimally invasive;Monitor;mortality;Motion;Neurons;Operative Surgical Procedures;Outcome;Pathology;Patients;Perfusion;Persons;Phase;Positioning Attribute;Procedures;Process;Property;prototype;Radiation;Randomized, Controlled Trials;real-time images;Risk;Robot;robot control;Rupture;Safety;Saline;Scanning;Sheep;Structure;success;Surgeon;System;Techniques;Time;Tissues;tool;Torque;Tube;Tumor Debulking;Validation;virtual;Visualization;white matter;wireless;Work;X-Ray Computed Tomography

PROJECT_TITLE: MRI-compatible concentric tube robot for intracerebral hemorrhage

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Although the influence of social experiences on mental and physical health are commonly accepted, the biological drivers of these effects are not yet understood. Understanding the biological underpinnings of social modulation of neural health and behavior are critical to improved human health outcomes. This project is relevant to NIH’s mission because assessment of the effects of a common environmental factor underrepresented in research models will ultimately allow identification of novel intervention strategies to ameliorate adverse consequences of social disruption and lead to enhanced health and reduced disability.

PI_NAMEs: GLASPER, ERICA R (contact);NEIGH, GRETCHEN N

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: adverse outcome;Affect;Alzheimer's disease related dementia;Anxiety;Area;Behavior;behavioral response;Biological;Biology;Brain;Brain region;California;Cessation of life;Chronically Ill;Coupled;Data;dementia risk;density;disability;Disease;early life stress;Emergency department visit;Environmental Risk Factor;experience;experimental study;Feeling;Health;healthy lifestyle;heart disease risk;Heart failure;Hippocampus;Hormones;Hospitalization;Human;Impairment;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;Intervention;Laboratories;Life;Link;Loneliness;lonely individuals;Longevity;Mediator;Medical;Mental Depression;Mental disorders;Mental Health;Metabolic;Metabolism;Microglia;Mission;Mitochondria;mitochondrial dysfunction;Modeling;mortality risk;Mus;Nature;Nerve Degeneration;neural;Neurobiology;neuroinflammation;Neurons;novel;Obesity;older adult;Outcome;Oxytocin;Pair Bond;Patients;Peripheral;Peromyscus;Persons;pharmacologic;physical conditioning;physical inactivity;Physiological;Predisposition;Prefrontal Cortex;prevent;psychologic;psychological outcomes;Public Health;Quality of life;Reporting;Research;response;Risk;Risk Factors;Rodent;Role;Signal Transduction;Smoking;social;social attachment;Social Behavior;social engagement;social influence;Social isolation;social relationships;Social support;Stimulus;Stress;stressor;Stroke;Structure;Suicide;Synapses;Synaptosomes;Testing;transcriptomic profiling;Translating;United States;United States National Institutes of Health;Vertebral column;Work

PROJECT_TITLE: From Social Discruption to Neural Compromise: Establishing Markers and Mediators