ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE This is a competing renewal application of a very successful Program Project Grant that has received continued funding for the past 11 years. During this time we have maintained a strong productivity, we have built a very collaborative and synergistic team and we have implemented substantial expertise and resources to study Chronic Wasting Disease (CWD), a prion disorder that continue to spread uncontrollably among cervids in USA. In this project, we will investigate the mechanism of CWD prion replication and the generation, adaptation and evolution of prion strains, the atomic resolution structure of infectious prions, the routes of transmission of the disease among animals, the evaluation of the zoonotic potential of CWD, the role of the environment on prion transmission and the development of efficient procedures to detect the infectious agent.

PI_NAMEs: SOTO, CLAUDIO  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TITLE: Pathogenesis, Transmission and Detection of Zoonotic Prion Diseases


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: TX

PROJECT_TERMS: Adherence;Advisory Committees;Animal Experimentation;Animals;Budgets;Caring;Cities;Collaborations;Colorado;Communication;Congresses;Data;data sharing;Databases;Detection;Goals;Institution;Maintenance;medical schools;meetings;member;Methodology;Office of Administrative Management;operation;Participant;Pathogenesis;Prion Diseases;Procedures;programs;Protocols documentation;Publications;Reagent;Reporting;Research Personnel;Resource Sharing;Site;Supervision;synergism;Texas;timeline;transmission process;United States National Institutes of Health;Universities;Update;videoconference;Zoonoses

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: TELLING, GLENN C (contact)

PROJECT_TERMS: Address;Animals;Biochemical;Biohazardous Substance;Biological Assay;biophysical techniques;Biophysics;Body Fluids;Brain;Breeding;Cell Line;Cells;cervid;Chronic Wasting Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Core Facility;Creutzfeldt-Jakob Syndrome;Decontamination;design;Detection;Detergents;Electron Microscope;Elements;Environment;Enzyme-Linked Immunosorbent Assay;Epitope Mapping;Epitopes;Equilibrium;experience;experimental study;Flow Cytometry;Fourier Analysis;Gene Targeting;Gene Transfer Techniques;Genotype;Goals;Housing;Human;Immunohistochemistry;Immunoprecipitation;improved;In Vitro;Individual;Infectious Agent;Infrastructure;innovation;Knockout Mice;Maps;Methodology;Methods;Microtus;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;mouse model;Mus;Nature;novel;operation;Participant;Pathogenesis;Perfusion;Polymorph;Predisposition;Preparation;Prion Diseases;Prions;Procedures;programs;Property;Proteolysis;Protocols documentation;PrP;PrP variant;PrPSc Proteins;Reagent;Research Personnel;Resolution;Resources;Rodent Model;Safety;Science;Services;Sheep;skills;Solubility;Source;Specificity;Spectroscopy, Fourier Transform Infrared;Standardization;Structure;System;Techniques;Time;Tissues;Titrations;Transgenic Mice;Transgenic Organisms;transmission process;Western Blotting;Zoonoses

PROJECT_TITLE: Core B: Scientific Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Over 80% of breast screening facilities in the US currently use 3-D digital breast tomosynthesis (DBT) to screen women for breast cancer, which offers superior tissue visualization compared to 2-D mammography and allows for estimation of true volumetric breast density. We will establish a large, diverse DBT consortium to enable the evaluation of novel commercial and research DBT volumetric density measures to predict invasive breast cancer, interval and advanced cancers, and to evaluate the impact of these DBT density measures on risk prediction models, AI algorithms, and risk-based thresholds for preventative therapy and supplemental imaging across a diverse population.

PI_NAMEs: KERLIKOWSKE, KARLA M;KONTOS, DESPINA ;VACHON, CELINE M (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: 3-Dimensional;advanced breast cancer;Advanced Malignant Neoplasm;Age;age difference;age group;Algorithms;Artificial Intelligence;artificial intelligence algorithm;Asian;Black race;Body mass index;Breast;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast density;Breast Magnetic Resonance Imaging;Calibration;Cancer Detection;cancer invasiveness;cancer risk;cancer subtypes;Chemoprevention;Classification;Clinic;Clinical;clinical risk;clinically relevant;cohort;Data;density;Development;Diagnosis;Digital Breast Tomosynthesis;Digital Mammography;Discrimination;Dose;Enrollment;Ethnic Origin;Evaluation;evidence base;FDA approved;follow-up;Frequencies;Goals;high risk;Image;improved;Individual;individualized prevention;innovation;Intervention;Life Style;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;mammography registry;Masks;Measurement;Measures;Menopausal Status;Modality;Modeling;Modernization;Nested Case-Control Study;novel;Outcome;Pennsylvania;Population;Population Heterogeneity;Prevention;Prevention approach;Preventive therapy;Prognosis;Race;racial population;Research;Resources;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Management;risk prediction;risk prediction model;risk stratification;Roentgen Rays;routine screening;San Francisco;screening;Source;supplemental screening;Technology;Three-Dimensional Image;Time;Tissues;tomosynthesis;Translating;University Hospitals;Visualization;Woman;Women's cohort

PROJECT_TITLE: Evaluation of novel tomosynthesis density measures in breast cancer risk prediction

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PROJECT_TERMS: Address;Affect;Alleles;American;Animal Diseases;Animals;Antibodies;Automobile Driving;Binding;Biological Models;Body Fluids;Cell Culture Techniques;Cells;cervid;Characteristics;Chemicals;Chronic Wasting Disease;Clinical;combat;Complement;conformer;Cultured Cells;Deer;design;Detection;Development;Disease;Disease susceptibility;Ectopic Expression;effective therapy;Epidemic;Epitopes;Evolution;Gene Targeting;Genetic;Genetic Engineering;Genetic Polymorphism;genetic selection;glycosylation;Goals;Heritability;Human;human PrP;improved;In Vitro;in vivo;Location;Methods;Modeling;Molecular Conformation;Mus;Mutation;neural;neuroblastoma cell;Neurodegenerative Disorders;novel;novel strategies;Outcome Measure;Pathogenesis;Pathogenicity;Peptide Hydrolases;Pharmaceutical Preparations;Phase;Physiological;Positioning Attribute;Predisposition;pressure;Prevalence;Prion Diseases;Prions;Process;Property;Proteins;PrP;PrP variant;PrPSc Proteins;Reindeer;Resistance;Resources;response;Risk;Risk Management;Sampling;Scandinavian;Science;Scrapie;Sheep;Soil;System;Tail;Tissues;tool;Transgenic Mice;Transgenic Organisms;transmission process;Variant;Western Blotting;Zoonoses

PROJECT_TITLE: Project 1: Modeling the Mechanisms of Prion Transmission, Strain Selection, Mutation and Species Barrier in Transgenic Mice


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Narrative Mantle cell lymphoma (MCL), an aggressive cancer arising in the lymphoid organs, is often the subject of acquired drug resistance (DR), posing a significanct challenge and unmet need for therapeutic treatment of the disease. In order to combat this DR, which can emerge from BCL-2 inhibitors such as ABT-199, we propose a combinatorial genetic and chemical approach to prevent further DR by targeting drug tolerant persister (DTP) and the DTP expansion population (DTEP) using CDK7/BRD4 and BCL-2 antagonists to target transcriptional machinery. We expect to (a) develop a comprehensive mechanistic epigenetic atlas to understand the development of drug resistance in MCL biology and (b) uncover a novel mechanism-driven therapy for MCL patients.

PI_NAMEs: DUCKETT, DEREK RONALD (contact);QI, JUN

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acceleration;acquired drug resistance;antagonist;Atlases;attenuation;B lymphoid malignancy;B-Cell Lymphomas;Back;BCL1 Oncogene;BCL2L1 gene;Biological Assay;Biology;Cell Line;Cell Survival;Cells;Chemicals;Chromatin;chromatin remodeling;Clinical;clinical remission;clinical translation;Clinical Trials;Collaborations;combat;combinatorial;Combined Modality Therapy;Complex;Development;Disease;Disease Progression;Drug Modelings;Drug resistance;drug resistance development;Drug Screening;Drug Targeting;Drug Tolerance;drug-sensitive;effective therapy;Effectiveness;Enhancers;Epigenetic Process;Evolution;experience;FDA approved;Genetic;Genetic Transcription;Growth;Hematopoietic Neoplasms;Heterogeneity;Human;Immunoprecipitation;improved;improved outcome;in vivo;in vivo Model;inhibitor;insight;Institution;Joints;Laboratories;lymphoid organ;Lymphoma;Lymphoma cell;Malignant Neoplasms;Mantle Cell Lymphoma;Mediating;Modeling;Molecular;mortality;Mus;Nature;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Population;pre-clinical;preclinical study;pressure;prevent;Prognosis;Protein Family;Publishing;Qi;Relapse;relapse patients;Resistance;Resistance development;resistance mechanism;Resources;response;Sampling;Signal Pathway;small molecule;standard care;STAT3 gene;targeted cancer therapy;Technology;Therapeutic;therapeutically effective;tool;transcriptome;transcriptome sequencing;Translations;Up-Regulation;Validation;Work;Xenograft procedure

PROJECT_TITLE: Transcriptional and Epigenetic Adaptation as Novel Therapeutic Vulnerabilities for Mantle Cell Lymphoma

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Modified Public Health Relevance Section There are currently 1.5 million new HIV infections each year. Thus, there is a great need to develop a safe and effective prophylactic HIV vaccine. In this application, we propose to evaluate an innovative algorithm to identify protective CD8+ T cell epitopes, HIV envelope trimer immunogens and a novel vaccine delivery platform of heterologous replication-incompetent chimpanzee adenoviral vaccine vector and lipid-nanoparticle messenger RNA within the non-human primate model in order to further inform the components that are necessary to achieve a prophylactic vaccine for HIV.

PI_NAMEs: GAIHA, GAURAV DAS (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Address;Adenovirus Vector;Algorithmic Analysis;Algorithms;Alleles;Animals;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biological Assay;CD4 Lymphocyte Count;CD8-Positive T-Lymphocytes;Cells;Clinical;Complement;Computational Technique;Data;Development;Dose;efficacy study;Encapsulated;Epitopes;Evaluation;Frequencies;Generations;global health;Goals;Health Priorities;HIV;HIV envelope protein;HIV Infections;HIV vaccine;Humoral Immunities;Immunity;Immunization;Immunize;immunogenic;immunogenicity;Immunologics;Individual;innovation;Laboratories;lipid nanoparticle;Macaca;Macaca mulatta;Messenger RNA;Modality;Modeling;Mutation;neutralizing antibody;nonhuman primate;novel vaccines;Pan Genus;Pathway Analysis;Phase;Phenotype;prevent;Preventive vaccine;prophylactic;protective efficacy;protein structure;Proteome;public health relevance;Replicon;resistance mutation;RNA;RNA vaccine;seroconversion;simian human immunodeficiency virus;SIV;Structure;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Vaccinated;Vaccination;vaccine delivery;vaccine development;vaccine efficacy;vaccine platform;vaccine response;Vaccines;vector vaccine;Viral;Viral Load result;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Investigating the Protective Efficacy of SIV/HIV T and B cell Immunity Induced by ChAd and mRNA

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transmissible Spongiform Encephalopathy (TSE)

PROJECT_TERMS: Affect;American;Animals;Area;Astrocytes;Biochemical;Biophysics;Brain;brain cell;Cattle;Cell Separation;Cell Survival;cell type;Cells;cervid;Characteristics;Chronic Wasting Disease;Collaborations;Collecting Cell;Collection;Color;Country;Coupled;cross-species transmission;Cryoelectron Microscopy;Deer;design;Detection;Deuterium;Digestion;Disease;disease transmission;Equine mule;Europe;European;Family suidae;Fluorescent Dyes;Gene Expression;Gene Targeting;Generations;Geographic Distribution;Geographic Locations;Goals;Hamsters;Health;Human;human PrP;Immunohistochemistry;Implant;In Vitro;in vivo;Individual;induced pluripotent stem cell;Infection;innovation;Knockout Mice;laser capture microdissection;Mammals;Mass Spectrum Analysis;Measures;Microglia;Mink;Modeling;Molecular;Mus;nerve stem cell;neural implant;Neurons;nonhuman primate;North America;Northern Europe;Oligodendroglia;Pathogenesis;Peptide Hydrolases;Predisposition;Prevalence;prevent;Prion Diseases;Prions;Property;Proteins;PrP;PrP gene;PrPSc Proteins;Reindeer;Resistance;Resolution;Risk;Role;Science;Scrapie;Sheep;Spectroscopy, Fourier Transform Infrared;Structure;Tail;Techniques;three dimensional structure;Tissue-Specific Gene Expression;transcriptome;Transfection;Transgenic Mice;transmission process;Zoonoses

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Social Determinants of Health;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: HOOVER, EDWARD ARTHUR (contact)

PROJECT_TERMS: American;animal resource;Animals;Area;Attention;Binding;Biological Assay;Body Fluids;Brain;cervid;Chronic Wasting Disease;conformer;contagion;cross-species transmission;Deer;Detection;detection method;disease transmission;Endemic Diseases;Environment;Environmental Impact;Environmental Pollution;Environmental Risk Factor;Evolution;Gene Targeting;Generations;Genotype;Geography;Health;Human;In Vitro;in vivo;Infection;Integration Host Factors;Laboratories;Lesion;Livestock;Lymphoid Tissue;Methodology;Methods;Molecular Conformation;Mus;neural;particle;Pathogenesis;Peptide Hydrolases;Prion Diseases;Prions;Property;prototype;PrP;PrPSc Proteins;Recombinants;Resistance;Risk;Risk Assessment;risk prediction;Role;Scandinavia;Scandinavian;Soil;Surface;Tail;Testing;Time;Tissues;Transgenic Organisms;transmission process;Variant;Western Blotting;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Project 3A: CWD Prion Shedding and Environmental Contamination: Role in Transmission and Zoonotic


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: BARTZ, JASON C (contact)

PROJECT_TERMS: American;animal resource;Animals;Area;Attention;Binding;Biological Assay;Body Fluids;Brain;cervid;Chronic Wasting Disease;conformer;contagion;cross-species transmission;Deer;Detection;detection method;disease transmission;Endemic Diseases;Environment;Environmental Impact;Environmental Risk Factor;Evolution;Gene Targeting;Generations;Genotype;Geography;Health;Human;In Vitro;in vivo;Infection;Integration Host Factors;Laboratories;Lesion;Livestock;Lymphoid Tissue;Methodology;Methods;Molecular Conformation;Mus;neural;particle;Pathogenesis;Peptide Hydrolases;Prion Diseases;Prions;Property;prototype;PrP;PrPSc Proteins;Recombinants;Resistance;Risk;Risk Assessment;risk prediction;Role;Scandinavia;Scandinavian;Soil;Surface;Tail;Testing;Time;Tissues;Transgenic Organisms;transmission process;Variant;Western Blotting;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Project 3B: Pathogenesis Transmission and Detection of Zoonotic Prion Diseases


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project narrative People with HIV have a higher prevalence of mental disorders compared to the general population, and the co- occurrence of these conditions are associated with adverse health outcomes in HIV, including poor adherence, poor viral suppression, and early mortality. A research training programme at the intersection of mental disorders and HIV is urgently needed to address the synergistic stress associated with these conditions. A Fogarty training programme at the University of Cape Town will allow us to train the next generation of researchers and clinician- scientists in behavioural medicine to address the challenges associated with co-occurring HIV and mental disorders and to become local and international leaders in HIV-associated behavioural medicine.

PI_NAMEs: JOSKA, JOHN ANTON (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Address;Adherence;African;antiretroviral therapy;Behavior;Behavioral Medicine;biopsychosocial factor;Caring;cohesion;cohort;comorbidity;Complex;Country;Degree program;Development Plans;Elements;Epidemic;Funding;Grant;HIV;improved;Institution;International;Intervention Trial;Master of Science;Mental Depression;Mental disorders;Mental Health;novel;organizational structure;Outcome;Persons;post-doctoral training;Post-Traumatic Stress Disorders;programs;recruit;Research;Research Training;Scientist;social;South Africa;South African;Stress;Substance Use Disorder;Training;Training Programs;treatment adherence;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: A Training Development Plan for HIV-associated Behavioural Medicine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(56)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC

ORG_STATE: NY

PHR: Project Narrative Most neuropsychiatric disorders have developmental origins, but knowledge about early risk factors, ontogeny, and mechanism remains scarce. We have identified a sensitive developmental period around adolescence, during which dopamine and serotonin modulate brain development to permanently and bi-directionally alter aggressive behavior and response to psychostimulants. Here we propose to study the underlying circuit-based mechanism, to ultimately improve diagnosis, prevention, and treatment strategies in psychiatric.

PI_NAMEs: ANSORGE, MARK SASCHA (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adolescence;Adult;Aggressive behavior;Behavior;Behavioral;Brain;Classification;Clinical;Clinical Research;Coupled;Data;Desire for food;Development;Diagnosis;Dopamine;Dopamine D2 Receptor;dopamine system;dopamine transporter;Dorsal;DRD2 gene;epidemiology study;Estrus;experimental study;Female;fighting;Functional disorder;gamma-Aminobutyric Acid;Genetic;Growth;Human;Hyperactivity;Hypothalamic structure;improved;Impulsive Behavior;Impulsivity;insight;Investigation;Knowledge;Lateral;Link;male;Maps;Mediating;Meditation;Modeling;Monitor;monoamine;mouse model;Mus;neural circuit;Neurons;neuropsychiatric disorder;Neurotransmitters;novel;Nucleus Accumbens;optogenetics;Pathway interactions;periadolescent;Phenotype;Play;Prevention strategy;Psychiatry;psychostimulant;Public Health;receptor expression;Research;Resolution;response;Rewards;Risk Factors;Role;Self Administration;sensor;Serotonin;Serotonin Receptor 5-HT2C;serotonin transporter;sex;Sex Differences;sexual dimorphism;Signal Transduction;Site;Social isolation;Stimulant;Testing;Time;tool;translational model;treatment strategy;Ventral Tegmental Area;Violence;women versus men

PROJECT_TITLE: Developmental Origins of Aggressive and Impulsive Behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: Project Narrative Understanding how leukemia cells hijack the translation machinery to allow high expression of short-lived oncoproteins is critical to develop effective therapies to treat this lethal blood disease. Recently, we identified a novel regulatory axis in AML in which PRMT9 overexpression induced eEF1A1 arginine methylation to promote AML cell maintenance. In this project, we will evaluate the functions of PRMT9 activity and eEF1A1 arginine methylation in human AML patient specimens and genetic mouse models with a goal of developing novel AML therapies based on PRMT9 inhibition.

PI_NAMEs: LI, LING  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Ablation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Arginine;Binding;Blood;c-myc Genes;cancer cell;CD34 gene;CEBPA gene;Cell Cycle;cell growth;Cell Maintenance;Cell Survival;Cells;cellular transduction;chemotherapy;cohort;conditional knockout;conventional therapy;Cytarabine;Cytogenetics;Daunorubicin;Dependence;dimethylarginine;Disease;effective therapy;Elongation Factor;Enzymes;FLT3 gene;Genetic;Goals;Growth;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Hematologic Neoplasms;Hematological Disease;Hematopoietic;Human;interest;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;leukemia;leukemia treatment;Leukemic Cell;Link;Maintenance;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;MCL1 gene;Mediating;Messenger RNA;Methylation;MLL-AF9;Modeling;Molecular;mouse model;mRNA Translation;Mus;Mutagenesis;Mutation;novel;Oncogenic;Oncoproteins;Outcome;overexpression;Pathogenesis;patient derived xenograft model;Patients;Peptide Elongation Factor 1;Play;polysome profiling;Proliferating;Protein Biosynthesis;Protein-Arginine N-Methyltransferase;Proteins;Proteomics;Relapse;ribosome profiling;Risk;Role;Signal Transduction;Small Interfering RNA;Source;Specimen;standard care;Stat5 protein;targeted treatment;Testing;therapeutically effective;TP53 gene;Translational Activation;Translations;transplant model;Transplantation;tumor;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Role of Protein Arginine Methyltransferase 9 in Acute Myeloid Leukemia Maintenance

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging

PHR: Project Narrative Protein glycation is a spontaneous reaction that is linked to a multitude of human diseases. Cells harbor a “hybrid” kinase/deglycase enzyme, fructosamine-3-kinase, to repair glycated proteins, yet despite its biological importance, we have a poor mechanistic understanding of how this enzyme works. We will use a multidisciplinary approach that integrates structural biology, enzymology, and systems biology to develop a compressive mechanistic understanding of FN3K-mediated protein repair.

PI_NAMEs: BINNING, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;Amines;Atherosclerosis;Binding;Biological;Biological Markers;Biomedical Research;Biophysics;Cells;Chemicals;Degenerative polyarthritis;Development;Diabetes Mellitus;Diagnosis;Disease;Enzymatic Biochemistry;Enzymes;Event;Excision;Fructosamine;Funding;glycation;Goals;Homologous Gene;human disease;Hybrids;improved;insight;interdisciplinary approach;Kinetics;KRP protein;Life;Link;link protein;Malignant Neoplasms;Mediating;Modification;Molecular;Nervous System Disorder;Non-Insulin-Dependent Diabetes Mellitus;Organism;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Polysaccharides;Post-Translational Protein Processing;Process;protein protein interaction;protein structure;Proteins;Proteome;Reaction;Regulation;repaired;Resolution;Role;Site;structural biology;sugar;Systems Biology;Techniques;Trees;Ubiquitination;Work;Writing

PROJECT_TITLE: Biophysical basis for enzyme mediated deglycation in protein repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Diabetes;Genetics;Mental Health;Neurosciences;Nutrition;Obesity;Prevention;Schizophrenia

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE  We use a multidiscipline approach to study the role of Mc4r in antipsychotic drug (APD)-induced weight gain. Our studies aim to establish that two widely prescribed APDs target a common hypothalamic pathway to cause hyperphagia and obesity. The overarching goal is to develop novel mechanism-based therapeutics to mitigate APD-induced metabolic syndrome in millions of patients.

PI_NAMEs: LIU, CHEN  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acute;Affect;Agonist;Animal Model;Antipsychotic Agents;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;Binding;Brain region;cell type;Cells;Child;Chromatin;Chronic;Clinical;Data;Desire for food;Development;Diabetes Mellitus;Discipline;driving force;drug action;Drug Interactions;Drug Targeting;Drug usage;drug-induced weight gain;Dyslipidemias;Electrophysiology (science);Energy Intake;Etiology;excessive weight gain;Expenditure;experimental study;FDA approved;Gene Expression;General Population;Genes;Genetic;Genetic Transcription;Genomics;Glucose Intolerance;Goals;Grant;Human;Hyperphagia;Hypothalamic structure;Impairment;improved;Individual;Insulin Resistance;interdisciplinary approach;inward rectifier potassium channel;Kir7.1 channel;Knockout Mice;Laboratory Animals;Link;Mediating;Medicine;Melanocortin 4 Receptor;Messenger RNA;Metabolic;Metabolic syndrome;Modeling;Molecular;Morbid Obesity;mouse model;Mus;Neurons;neuropsychiatry;new therapeutic target;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesogenic;olanzapine;paraventricular nucleus;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physical activity;postsynaptic;Potassium;Potassium Channel;receptor;receptor expression;Research;Resources;restoration;Risperidone;Role;Schizophrenia;Serotonin Receptor 5-HT2C;side effect;Signal Transduction;single nucleus RNA-sequencing;Site;Suggestion;Therapeutic;Time;transcriptome;transcriptome sequencing;United States National Institutes of Health;Weight Gain;Work

PROJECT_TITLE: Hypothalamic MC4Rs and Antipsychotic Drug-Induced Metabolic Syndrome

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Health Services;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The WISDOM study is a pragmatic trial designed to improve screening by harnessing our growing understanding of breast cancer risk and predisposition. We are testing a personalized approach, which tailors screening to individual risk within existing guidelines, assigning more intensive screening for those at higher risk and more likely to benefit, and less for those at lower risk who might otherwise suffer harms of screening for less benefit. The proposal `Expanding the WISDOM Study's Diversity, Reach, and Generalizability' will enable us to extend the geographic and ethnic reach of this innovative study, which includes a coverage with evidence progression model, to increase the power and generalizability of our study results.

PI_NAMEs: ESSERMAN, LAURA J (contact)

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: Adopted;Adoption;Advocate;Age;Alabama;arm;Blue Cross;Blue Shield;Boston;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;Breast Cancer Treatment;breast density;California;Cancer Biology;cancer predisposition;Caring;Chicago;Clinical;clinical research site;Clinical Services;Collaborations;comorbidity;Conflict (Psychology);Confusion;Contracts;cost;Country;Data;demographics;design;Disease;Employee;Enrollment;Ethnic Origin;Exhibits;experience;Family;Feedback;Florida;Frequencies;Funding;Genes;Genetic Predisposition to Disease;Geography;Goals;Guidelines;Health;Healthcare;high risk;Home;Illinois;improved;Individual;individualized medicine;Infrastructure;Inherited;innovation;Insurance Carriers;Insurance Coverage;Intention;International;Internist;Investments;Knowledge;knowledge translation;Learning;learning progression;Louisiana;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Measures;Midwestern United States;Minnesota;Modality;Modeling;Modernization;Mutation;New Jersey;Oregon;Outcome;outreach;Paralysed;Participant;patient oriented;Patient-Focused Outcomes;personalized approach;personalized screening;polygenic risk score;Population;population based;Population Heterogeneity;pragmatic trial;precision medicine;Predisposition;preference;preventive intervention;programs;psychologic;Randomized;Recommendation;Recording of previous events;recruit;Research Institute;Risk;Risk Assessment;Risk Factors;routine screening;Safety;Science;screening;screening guidelines;Secure;Single Nucleotide Polymorphism;Site;Societies;socioeconomics;South Carolina;study population;Target Populations;Technology;Testing;testing services;Time;Traction;Translating;trial comparing;trial design;trial enrollment;United States;United States Department of Veterans Affairs;Universities;Update;uptake;Utah;Variant;Veterans;Washington;Woman

PROJECT_TITLE: Extending the Diversity, Reach, and Generalizability of the WISDOM Study

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

PHR: 8. PROJECT NARRATIVE South Africa has the world’s largest HIV population with approximately 7.52 million people with HIV (PWH), and prevalence of HIV associated neurocognitive impairment (NCI) is high (23% to 76%). Cognitive remediation training has been developed for PWH, but not in South Africa. Adapting and developing cognitive remediation training for South African PWH, allowing for rehabilitation of these patients, can have far reaching health benefits, such as enhanced physical and mental health related to better medication adherence and improved psychosocial outcomes, including mental health.

PI_NAMEs: GOUSE, HETTA-MARI ;THOMAS, KEVIN GARTH (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Activities of Daily Living;Address;Affect;Africa;Aging;aging population;aging process;Anti-Retroviral Agents;antiretroviral therapy;Attention;Behavioral;Caring;Clinic;Cognition;Cognitive;cognitive rehabilitation;Cognitive remediation;cognitive skill;cognitive training;Communities;community advisory board;comorbidity;computerized;Computers;Consultations;Control Groups;Control Locus;daily functioning;Decision Making;depressive symptoms;Disease;Educational Intervention;Eligibility Determination;Epidemic;evidence base;experience;Focus Groups;functional status;Future;future implementation;Goals;Grant;Health;Health Benefit;Health Status;Healthcare;Healthcare Systems;HIV;HIV Infections;HIV-associated neurocognitive disorder;Impaired cognition;improved;Incidence;information processing;Infrastructure;infrastructure development;Instruction;Intervention;Intervention Studies;Interview;Language;Life Expectancy;Linguistics;Measures;Medical;medication compliance;Mental disorders;Mental Health;mental state;Methodology;Methods;Moods;neighborhood disadvantage;Neurobehavioral Manifestations;Neurocognition;Neurocognitive Deficit;novel;Occupational Therapist;Outcome;Patients;Persons;phase 1 study;phase 2 study;physical conditioning;Physicians;Pilot Projects;pilot test;Population;post intervention;Prevalence;Primary Health Care;Procedures;processing speed;Professional counselor;programs;Provider;Psyche structure;psychosocial outcome;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Resource-limited setting;Resources;retention rate;Risk;screening;Short-Term Memory;skills;skills training;sociodemographics;socioeconomic disadvantage;South Africa;South African;Specialist;Speed;symptom management;technology intervention;Testing;therapy adherence;therapy development;Time;Training;Translating;United States National Institutes of Health;Unsafe Sex;usability;Viral;Work;working group

PROJECT_TITLE: Building Resources to Achieve Improvement in Neurocognition (B.R.A.I.N.) inpeople with HIV.

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative This research proposal is focusing on the development and refinement of innovative analytical methods and cutting-edge technologies using agnostic deep learning approaches that will substantially improve detection of glaucoma and its progression forecasting and monitoring in order to prevent blindness.

PI_NAMEs: ISHIKAWA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;analytical method;Area;Atlases;Black Box;Blindness;brain magnetic resonance imaging;Caring;case-by-case basis;Clinic;Clinic Visits;Clinical;clinical application;Clinical Management;clinical practice;cohort;Collaborations;Color;Complex;computerized;cost;Cross-Sectional Studies;Data;Data Set;Decision Making;deep learning;deep learning model;Detection;Development;Disease;disease model;Disease Progression;Early Diagnosis;Eye;feature selection;follow-up;Future;Glaucoma;Image;Image Analysis;image processing;imaging modality;Imaging technology;improved;in vivo;Individual;individual patient;innovation;insight;Intervention;Investments;Knowledge;Learning;Location;longitudinal analysis;longitudinal dataset;Machine Learning;machine learning method;Maps;Measurable;Measurement;Medical Imaging;Methods;Modeling;Monitor;Morbidity - disease rate;novel;ocular imaging;Ophthalmology;Optical Coherence Tomography;Outcome;Patients;Performance;personalized approach;personalized medicine;personalized predictions;predictive modeling;preservation;prevent;programs;Research;Research Proposals;Retina;retinal nerve fiber layer;Sampling;Series;Speed;Structure;System;Techniques;Technology;Testing;theories;Thick;Time;Tissues;tool;Training;treatment planning;trend;Vision;Visit;Visual Fields

PROJECT_TITLE: Deep Learning Approaches for Personalized Modeling and Forecasting of Glaucomatous Changes


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Networking and Information Technology R&D (NITRD);Obesity

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale Modeling The coronary circulation is regulated by numerous mechanisms to ensure that myocardial oxygen supply is adequate to meet the metabolic demand over a variety of patho-physiologic conditions. Despite the crucial nature of this intrinsic response, understanding the mechanisms responsible for coronary flow autoregulation remains one of the most fundamental questions in the coronary field today. In this project, we propose a combination of novel computational tools and animal experiments to improve our understanding of the mechanisms affecting autoregulation of coronary flow, in both health and disease.

PI_NAMEs: BEARD, DANIEL A;FIGUEROA, CARLOS ALBERTO (contact);TUNE, JOHNATHAN D

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: Accounting;Address;Adrenergic Agents;Affect;Anatomy;Anesthesia procedures;Animal Experiments;antagonist;arteriole;Automobile Driving;Behavior;Blood capillaries;Blood flow;Blood Vessels;Cardiac Output;Cardiovascular system;Catecholamines;Cells;Compensation;computer studies;computerized tools;Conscious;Coronary;Coronary Circulation;coronary perfusion;coronary vasculature;Coupling;Data Analyses;Disease;Distal;electrical property;Electrophysiology (science);Endothelium;Equilibrium;experimental study;Family suidae;Feedback;Goals;Health;Heart;Histologic;Homeostasis;hypoperfusion;Hypoxemia;Impairment;improved;in vivo;indexing;Infusion procedures;insight;instrument;Ischemia;ischemic injury;Knowledge;Lesion;Measurement;Measures;mechanical properties;Mechanics;Mediating;Mediator;Membrane;Metabolic;Metabolic Control;Metabolic Pathway;Microvascular Dysfunction;Modeling;models and simulation;Morbidity - disease rate;mortality;multi-scale modeling;Myocardial;Myocardial dysfunction;Myocardial perfusion;Myocardium;Nature;neural;novel;Obesity;Oxygen;Oxygen Consumption;patch clamp;Pathologic;Pathway interactions;Perfusion;Peripheral Resistance;phenome;phenomenological models;physiologic model;Physiological;porcine model;Potassium Channel;preservation;pressure;Production;Property;receptor;Regulation;Resistance;response;Signal Pathway;Signal Transduction;simulation;Site;Smooth Muscle;Smooth Muscle Myocytes;Stenosis;Structural Models;System;Testing;theories;Vascular Smooth Muscle;Vasodilation;Vasodilator Agents;Venous;Ventricular;Work

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Behavioral and Social Science;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative As of 2021, Kenya was the home of approximately 1.4 million people living with HIV (PLVHIV) and ranked eighth globally for the highest number of PLHIV residing within a country. Given this burden of disease, it is imperative that Kenyan investigators have the training to recognize gaps in the HIV prevention and care cascades, design implementation strategies to address those gaps, assess the effectiveness of these strategies, and translate findings into best practices to disseminate. By strengthening in-country educational infrastructure, expanding local human resource capacity in strategic areas, promoting sustained engagement in research, enhancing mentorship capacity, and supporting research collaboration with county health teams, this training program will build sustainable research capacity for HIV Implementation Science and Dissemination Research (HIV-ID) and promote decolonization of global health.

PI_NAMEs: NANGAMI, MABEL ;NYANDIKO, WINSTONE ;WOOLS-KALOUSTIAN, KARA KAY (contact)

PROJECT_TERMS: Academia;Address;AIDS prevention;American;Area;Caring;Collaborations;college;Country;County;County Government;Degree program;doctoral student;Education;Educational workshop;Environment;European;Fellowship Program;global health;Growth;Health;health care availability;Health Sciences;HIV;Human Resources;implementation science;Indiana;Infrastructure;innovation;Joints;Kenya;Learning;medical schools;Mentorship;Modeling;Process;program dissemination;programs;Public Health Schools;Research;Research Project Grants;Research Support;Resources;Students;Training;Training Programs;Training Support;Universities

PROJECT_TITLE: Training in HIV Implementation Science and Dissemination in Kenya


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Traumatic brain injury (TBI) is a major public health issue, which has a significant impact upon our healthcare system. Economic analyses of the annual cost of TBI-related disabilities range from $4.5 billion in direct expenditure (medical care and services) to $70.6 billion in injury-related work loss and disability. Our goal in the proposed studies is to determine the underlying mechanism(s) through which stress exacerbates behavioral outcomes after injury and to leverage these findings into therapeutic regimes that can be translated from the bench to the clinic to mitigate the effects of TBI in patients.

PI_NAMEs: BHATNAGAR, SEEMA ;COHEN, AKIVA S (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Affect;Anxiety;anxiety-related behavior;Attention;behavioral outcome;bench to bedside;Caring;Cells;Chronic;Chronic stress;Clinical;Cognitive;cost;Data;debilitating symptom;design;designer receptors exclusively activated by designer drugs;Direct Expenditure;disability;economic evaluation;Environment;Excessive Daytime Sleepiness;Exhibits;experience;experimental study;Exposure to;Female;flexibility;fluid percussion injury;Frequencies;Future;Genetic;Glutamates;Goals;Healthcare Systems;hypocretin;improved;Individual;injured;Injury;Lateral;male;Medical;Memory;men;Mental Health;mild traumatic brain injury;Modeling;Mood Disorders;Mus;National Institute of Neurological Disorders and Stroke;neural;Neurobiology;Neurons;Neuropeptides;Neurosecretory Systems;Outcome;Patients;Predisposition;promote resilience;psychiatric symptom;Psychological Stress;Public Health;Quality of life;Rattus;Recovery;Regulation;resilience;response to brain injury;Risk;Role;segregation;Services;Severities;sex;Sex Differences;Site;social defeat;Source;Stress;Stress and Coping;Subgroup;Symptoms;Synapses;TBI Patients;Testing;Therapeutic;tool;Translating;Traumatic Brain Injury;Variant;Woman;Work

PROJECT_TITLE: Orexin regulation of responses to brain injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Rehabilitation

ORG_CITY: SAN DIEGO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Our program is designed to train clinically savvy, ethical researchers who are prepared to investigate the nature of language and communicative disorders across the lifespan and in diverse populations. In a highly collaborative and interdisciplinary training environment, trainees will develop advanced research skills, acquire clinical perspectives, and pursue professional development. Thus, we will continue to graduate researchers that meaningfully contribute to the fields of communication disorders and related fields.

PI_NAMEs: LOVE-GEFFEN, TRACY  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Communication impairment;Neurocognitive

PROJECT_TITLE: Neurocognitive Approaches to Communication Disorders


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MIAMI

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PHR: Public Health Relevance/Narrative The proposed research exploits the synergy of histone methylation inhibition with DNA base excision repair in contracting the expanded GAA repeats of Friedreich's ataxia to develop a frataxin gene-targeted CRISPR/dCas9 system fused with histone demethylase. The gene-targeted system will reveal the precise mechanisms for histone demethylation to coordinate with DNA repair, causing the contraction of the expanded repeats at the frataxin gene. The proposed research will significantly advance the development of gene therapy for Friedreich's ataxia and other repeat expansion diseases; thus, it is relevant to the NIH mission of reducing illness and disability.

PI_NAMEs: LIU, YUAN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: 3' Flanking Region;8-hydroxyguanosine;Aconitate Hydratase;Advanced Development;Alkylating Agents;Ataxia;autosome;Base Excision Repairs;Biological Assay;Brain;Cardiomyopathies;Cell Differentiation Induction;Cell Differentiation process;Cells;Chromatin;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Contracts;demethylation;disability;Disease;DNA;DNA Double Strand Break;DNA Modification Process;DNA Polymerase β;DNA Repair;DNA Sequence;DNMT3a;effective therapy;Epigenetic Process;Excision Repair;frataxin;Friedreich Ataxia;Gene Expression;Gene Silencing;Gene Targeting;gene therapy;Genes;Genome;Genome Stability;Genomic Instability;Guide RNA;Heterochromatin;histone demethylase;Histone H3;histone methylation;histone modification;Histones;Human;induced pluripotent stem cell;insight;Introns;Iron;Link;Lobe;Lysine;Maps;Mediating;Messenger RNA;Methylation;Mission;mitochondrial dysfunction;nerve stem cell;neural;Neurodegenerative Disorders;Neuromuscular Diseases;Neurons;novel;novel strategies;Oxidative Stress;Pathway interactions;Patients;Phenotype;Plasmids;Production;Proteins;public health relevance;recruit;repair enzyme;Research;RTH-1 Nuclease;Streptococcus pyogenes;Sulfur;synergism;System;temozolomide;Testing;Tissues;Transcription Elongation;Transfection;Transgenic Mice;United States National Institutes of Health;Up-Regulation;Vertebral column

PROJECT_TITLE: A CRSIPR/dCas9-Targeted Histone Demethylation Induces GAA repeat contraction

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Tumor microenvironment acidity is a characteristic of breast cancers of all sizes, grades, and stages. We propose to develop and implement a holistic approach for tumor acidity imaging with pre-operative multi-parametric MRI (mpMRI) and novel pHLIP® ICG near infrared fluorescent (NIRF) intra-operative imaging. The long-term goal is to improve the standard of care: pre-operative non-invasive non-contrast TME acidity imaging with mpMRI will allow the identification of more aggressive tumor phenotypes that require intensified treatment, improve planning of surgical and treatment strategies, and enable monitoring spatial-longitudinal of tumor biology with treatment; and intra-operative pHLIP-ICG NIRF imaging will allow an improved up-front resection of primary breast cancer, which could allow a shift from more extensive surgeries to highly accurate tissue-sparing lumpectomies – therefore improving the quality of patients’ lives.

PI_NAMEs: MORROW, MONICA  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Acidity;Adjuvant Therapy;Adverse event;Anxiety;Breast Cancer Patient;breast lumpectomy;Breast-Conserving Surgery;Cancerous;carbonate dehydratase;Cd68;Cell surface;Cessation of life;Characteristics;Chemicals;Clinical;Clinical Research;Clinical Trials;Development;Diffusion Magnetic Resonance Imaging;Dose;Drug Kinetics;Dyes;Environment;Excision;FDA approved;Female;first-in-human;fluorescence imaging;Goals;Growth;Histologic;Histopathology;holistic approach;human study;Image;Image-Guided Surgery;imaging agent;Immunohistochemistry;improved;Indocyanine Green;Injections;insight;Intravenous;lactate dehydrogenase A;Lesion;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant Breast Neoplasm;Malignant Neoplasms;Mastectomy;Metalloproteases;MMP9 gene;Monitor;Motion;Neoadjuvant Therapy;neoplastic cell;novel;Nuclear Protein;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Peptides;Phase;phase I trial;Phenotype;Primary Neoplasm;Prognosis;Proliferating;Property;prospective;Protocols documentation;real-time images;Reference Standards;Resistance;risk stratification;Safety;Specimen;Stains;standard of care;Structure;targeted imaging;targeted treatment;Technology;Testing;Time;Tissues;tool;treatment planning;treatment strategy;tumor;Tumor Biology;Tumor Markers;tumor microenvironment;Tumor stage;Tumor Tissue;Tumor Volume;Tumor-associated macrophages;Visualization;Woman

PROJECT_TITLE: Deciphering the Acidic Tumor Environment: A Phase I/IIa Study of Pre-Operative Multiparametric MRI and pHLIP® ICG Intra-Operative Fluorescence Imaging of Primary Breast Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: NARRATIVE This study aims to characterize the mechanisms underlying the specific induction of programmed cell death in HIV-1 reservoirs, and to identify the mechanisms counteracting cell death that could be targeted to improve the clearance of the HIV reservoirs.

PI_NAMEs: WANG, JIN  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Aftercare;antiretroviral therapy;Apoptosis;Apoptotic;Autophagocytosis;BCL2 gene;Biological Assay;CASP3 gene;Caspase Inhibitor;Cell Death;Cell Death Induction;Cell Death Signaling Process;Cell Survival;Cells;cellular targeting;Development;DNA;Environment;Epigenetic Process;experimental study;Family member;fitness;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;HIV;HIV Infections;HIV-1;humanized mouse;Immune;Immune response;improved;in vivo;Induction of Apoptosis;Inflammasome;Interruption;IRF3 gene;latent HIV reservoir;Lymphoid;Macrophage;Measures;Mediating;Metabolic Pathway;Molecular;mouse model;Myelogenous;Myeloid Cells;novel;Pathway interactions;Patients;Persons;reactivation from latency;Regulation;Reporting;Resistance;Resolution;response;RIPK1 gene;RNA;Role;Sampling;sensor;Shock;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Stimulator of Interferon Genes;T-Lymphocyte;Techniques;Testing;Tissues;transcription factor;transcriptome;transcriptomics;Up-Regulation;Vial device;Viral;viral detection;viral DNA;viral rebound;Viral reservoir;viral RNA;Virus

PROJECT_TITLE: Regulation of Cell Death in HIV Reservoirs


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The proposed project is relevant to the public health because Type 1 Diabetes is an incurable autoimmune condition that is increasing in prevalence. We propose to apply novel technologies to determine biophysical parameters of T cell receptor interaction with self-antigens to better understand mechanisms of tolerance and their failure in autoimmunity. The results of this project will provide a framework for improving the efficacy of TCR-redirected regulatory T cell therapy.

PI_NAMEs: BETTINI, MARIA  (contact);EVAVOLD, BRIAN D

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affinity;Alleles;Antigen Presentation;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Beta Cell;beta Chain Antigen T Cell Receptor;Binding;biophysical properties;CD4 Positive T Lymphocytes;CDR1 gene;Cell Physiology;Cells;Complementarity Determining Regions;Complex;Data;design;diabetogenic;Disease;Disease Progression;effector T cell;Eragrostis;Exhibits;Experimental Animal Model;Failure;Family;FOXP3 gene;Functional disorder;Genetic;Germ Lines;Goals;Histocompatibility;HLA-DR4 Antigen;Human;humanized mouse;improved;insight;Insulin-Dependent Diabetes Mellitus;Knowledge;Measurement;Measures;mechanical force;Mediating;Modeling;Mus;new technology;novel;Outcome;Peptide Receptor;Peptides;Predisposition;Prevalence;Process;Proteins;Public Health;Publishing;Receptor Activation;Regulatory T-Lymphocyte;response;Risk Factors;Specificity;Structure;Surveys;System;T cell response;T cell therapy;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Development;T-Cell Receptor;T-Lymphocyte;TCR Activation;Technology;Testing;Therapeutic;Treg therapy;Work

PROJECT_TITLE: Biophysical parameters of self-reactive TCR engagement in T1D


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Project Narrative  Most of the vertebrate genome finds its ultimate origin in transposable elements, once best known as prototypical selfish DNA, and their annotation is crucial for genome sequence analysis and our understanding of their unrivaled impact on genome biology and evolution. Their de novo discovery and description has become a bottleneck in the genome analysis of the thousands of new species sequenced every year. In this proposal, we describe a plan to make foundational changes to the way RepeatMasker adjudicates TE alignments and assigns confidence to annotations, and present two feasible and novel paths to improving the generation of new TE libraries through the use of multi-species genome alignments and ancestral reconstructions and core algorithmic changes to our RepeatModeler discovery tool.

PI_NAMEs: HUBLEY, ROBERT MACDONALD;SMIT, ARIAN FREDERICUS ANTHONIUS (contact);WHEELER, TRAVIS JOHN

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: adjudication;Age;Algorithms;Biology;Calibration;Classification;cluster computing;Code;Communities;Complex;Computer software;conflict resolution;Consensus Sequence;Data Set;Databases;Detection;Development;Distant;DNA Insertion Elements;DNA Transposable Elements;DNA Transposons;Elements;Environment;Event;Evolution;Exposure to;Family;Funding Agency;Generations;Genome;genome analysis;genome annotation;Growth;Hand;Human;Human Resources;improved;Knowledge;Libraries;Light;Maintenance;mammalian genome;Mammals;markov model;Methods;Modeling;Mutation;novel;Organism;Phylogenetic Analysis;Phylogeny;Process;programs;reconstruction;Reporting;Research;Resolution;search engine;Selfish DNA;Sensitivity and Specificity;Sequence Alignment;Sequence Analysis;Shapes;Source;Speed;Tandem Repeat Sequences;tool;Trees;trustworthiness;Update;usability;vertebrate genome;Vertebrates;Work

PROJECT_TITLE: Development and Maintenance of RepeatMasker and RepeatModeler

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Epilepsy;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Rehabilitation

ORG_DEPT: NEUROSURGERY

PHR: PROJECT NARRATIVE We propose a pilot clinical trial of a speech neuroprosthetic device for patients with severe paralysis, resulting from stroke, amyotrophic lateral sclerosis (ALS) and progressive muscle disorders. This is a critical step towards a clinically viable technology to restore communication and quality-of-life for affected individuals.

PI_NAMEs: CHANG, EDWARD  (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustics;Adult;Affect;Algorithms;Amyotrophic Lateral Sclerosis;Area;Articulation;Articulators;Auditory;Brain;brain computer interface;Brain Stem Infarctions;Chronic;Clinical;clinical application;Clinical Trials;cohort;Communication;communication device;Communication Tools;Communications Media;density;design;Devices;Disease;Electrocorticogram;Electrodes;Electroencephalography;Epilepsy;Feasibility Studies;Feedback;Future;Genetic Transcription;Goals;Human;Impairment;Implant;implantation;improved;Individual;innovation;Institutional Review Boards;Investigation;Jaw;Language;Larynx;Lateral;Lip structure;Medical;Methods;Microelectrodes;Modeling;Motor;Motor Cortex;Muscular Dystrophies;Myopathy;Nervous System Trauma;neural;neural network;neuroprosthesis;neurotransmission;Operative Surgical Procedures;Outcome;Paralysed;patient population;Patients;Performance;Persons;phrases;pilot trial;Play;Population;primary outcome;Production;Property;Prosthesis;Quality of life;recurrent neural network;restoration;Risk;Safety;Sampling;Scalp structure;signal processing;Signal Transduction;Specific qualifier value;Speech;speech synthesis;Speed;spelling;Stroke;Study Subject;Surface;System;Target Populations;Technology;Text;Time;Tongue;Training;Weight;Work

PROJECT_TITLE: A Pilot Clinical Trial for Speech Neuroprosthesis


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE: This application will develop and integrate a series of technical solutions that improve efficiency and reduce variability of current magnetic resonance imaging (MRI) exams, into a true 5-minute clinical exam. We will train artificial intelligence models to enable single button-push MRI exams, using a multi-center, multi-vendor approach to ensure the reproducibility and generalizability of our results. We focus on achieving these goals on the development of a rapid and quantitative MRI method that can detect and quantify early features of fatty liver disease and liver iron overload, to facilitate preventative treatment for millions of Americans who would otherwise go undiagnosed.

PI_NAMEs: HERNANDO, DIEGO ;REEDER, SCOTT B. (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Abdomen;Affect;American;Anatomy;Anemia;Artificial Intelligence;artificial intelligence model;automated analysis;Biological Markers;Biopsy;Blood Transfusion;Breathing;Chemical Engineering;Chemicals;Child;chronic liver disease;Cirrhosis;Clinical;clinical examination;clinical implementation;clinical translation;comorbidity;cost;Cost Analysis;Data;density;design;Development;Diagnostic tests;diagnostic value;Diffuse;Engineering;Ensure;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;FDA approved;Goals;Health;Hepatic;Hepatocyte;Hereditary hemochromatosis;Image;Image Analysis;improved;innovation;Intervention;Iron;Iron Overload;Length;Liver;Liver diseases;Liver Failure;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Methods;Monitor;Morphologic artifacts;Motion;MRI Scans;National Institute of Biomedical Imaging and Bioengineering;NIH Program Announcements;non-alcoholic fatty liver disease;Non-Invasive Detection;nonalcoholic steatohepatitis;novel;Patients;Persons;Populations at Risk;Prevention;Preventive treatment;Primary carcinoma of the liver cells;Protocols documentation;Protons;Quantitative Evaluations;quantitative imaging;Reporting;Reproducibility;Research Personnel;respiratory;Scanning;Schedule;Sensitivity and Specificity;Series;Source;Staging;Surveys;Testing;Time;tool;Training;Transfusion;Translations;Triglycerides;Validation;Vendor;Work

PROJECT_TITLE: Fully Automated High-Throughput Quantitative MRI of the Liver

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: DAVIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Public health scientists lack reliable data on the burden of many infectious diseases, which is a barrier to effective control measures. This project will develop an open-source R software package, called serocalculator, to estimate seroincidence from cross-sectional serologic response data. We expect this tool will be used to generate incidence estimates for a range of infectious diseases, providing critical information needed to inform disease control interventions and ultimately reduce the burden of disease.

PI_NAMEs: AIEMJOY, KRISTEN ;MORRISON, DOUGLAS EZRA (contact)

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Adoption;Animals;Antibodies;Antibody Response;Archives;burden of illness;catalyst;Code;Communicable Diseases;Communities;Computer software;computerized data processing;Cross-Sectional Studies;Data;Data Analyses;data cleaning;data de-identification;Data Science;Data Set;Databases;Development;Disease;disease diagnostic;Disease Surveillance;disorder control;Documentation;Education;Educational Curriculum;Educational workshop;Epidemiology;epidemiology study;experience;Funding Opportunities;Future;graphical user interface;Human;Incidence;Individual;individual variation;Infection;innovation;Intervention;Language;Licensing;Maintenance;Manuals;Measures;Methodology;Methods;Modeling;National Institute of Allergy and Infectious Disease;novel;open source;pathogen;Population;population survey;Preparation;Programming Languages;Public Health;Publishing;Reporting;repository;Research Personnel;response;Scientist;Serology;serosurvey;Serum;Signal Transduction;simulation;Site Visit;Statistical Computing;Statistical Data Interpretation;symposium;Testing;theories;tool;Training;user-friendly;Visualization;Work

PROJECT_TITLE: Serocalculator: Estimating Incidence Rates from Serological Data


ADMINISTERING_IC: LM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Health Services;Precision Medicine

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: 8. Project Narrative Going to the doctor has largely become an experience of risk calculation for patients, while for clinicians and researchers, the emergence of evidence-based medicine, as well as the more recent turn to precision and personalized medicine, are predicated on the ability to statistically process large quantities of medical data. This grant will support research for a monograph that transforms our understanding of the history of modern medicine by analyzing how statistical tools and concepts once understood as relevant only in aggregate, and for population-level analysis, came to be understood as relevant for making claims of causality and efficacy for individuals in the clinic. As the first book- length history of biostatistics and clinical epidemiology, this work will be of great interest to audiences in history of medicine, health policy, clinical medicine, epidemiology, and related medical social sciences, as well as to members of the lay public who find themselves curious about the central role of probability and statistics in medical treatment.

PI_NAMEs: PHILLIPS, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Address;Agriculture;American;authority;Biomedical Research;Biometry;Books;carcinogenicity;Characteristics;Clinic;Clinical;clinical epidemiology;Clinical Medicine;Clinical Practice Guideline;Clinical Trials;Computer Simulation;Curiosities;Data;Data Aggregation;Decision Making;design;Development;Discipline;Education;Epidemiologist;Epidemiology;Etiology;evidence base;Evidence Based Medicine;Exclusion;experience;Government;Grant;Health;Health Policy;History of Medicine;Individual;individual patient;innovation;Insurance Carriers;interest;Intervention;Journals;Knowledge;Laboratories;Length;Literature;Measures;Medical;Medical Research;medical specialties;Medicine;member;Meta-Analysis;models and simulation;Modern 1601-history;Modern Medicine;Monograph;National Cancer Institute;novel;novel therapeutics;Observational Study;Operative Surgical Procedures;Patient Care;Patients;people of color;personalized medicine;Physicians;Play;Population;Population Genetics;precision medicine;Pregnant Women;pressure;Probability;Procedures;Production;Professional Organizations;programs;Prospective Studies;Psychiatry;Public Health;public health insurance;randomized, clinical trials;Recording of previous events;Research;Research Personnel;Research Support;Resistance;response;Retrospective Studies;Risk;Role;screening guidelines;Series;Shapes;Social Sciences;sociologist;Statistical Computing;Statistical Data Interpretation;statistics;Techniques;Testing;Therapeutic Agents;tool;Training Programs;United States Environmental Protection Agency;United States Food and Drug Administration;United States National Institutes of Health;United States Public Health Service;Universities;welfare;Work

PROJECT_TITLE: Number Doctors: The Emergence of Biostatistics and the Reformation of Modern Medicine


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Lymphatic Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Crohn's disease has long been associated with the concept of impaired lymphatic drainage. In this application, we reveal that impaired lymph flow is due to formation of tertiary lymphoid organs (TLOs) that obstruct the outflow lymphatic vessels of the gut. In this application, we seek to determine how these TLOs form and whether they exacerbate disease, following up on surprising evidence that they may have a benefit in containing the spread of systemic manifestations of Crohn's disease.

PI_NAMEs: RANDOLPH, GWENDALYN J (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Address;Affect;Anti-Tumor Necrosis Factor Therapy;B-Lymphocytes;Biogenesis;bone;bone loss;Cells;Complex;Crohn's disease;cytokine;Data;Disease;Disease Progression;draining lymph node;Encapsulated;Endothelium;Environment;Functional disorder;Gene Expression;Genes;Histologic;human tissue;Ileitis;ileum;Image;Immune;Immunize;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Laboratory Study;Left;Ligands;Localized Disease;Lymph;lymph flow;lymph nodes;Lymphangiogenesis;Lymphangitis;Lymphatic;lymphatic circulation;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic Endothelium;lymphatic valve;lymphatic vasculature;lymphatic vessel;Lymphoid;Maintenance;Mediator;mesenteric lymphatics;Mesentery;Messenger RNA;mouse model;Mus;Muscle;Muscular Atrophy;Mutation;Nature;neutralizing monoclonal antibodies;Obstruction;Pathology;Pathway interactions;Patients;Phenotype;predictive modeling;pressure;prevent;programs;Receptors, Tumor Necrosis Factor, Type II;Research;Resected;Role;Running;Signal Transduction;single cell sequencing;Site;Skeletal Muscle;Source;Systemic disease;tertiary lymphoid organ;Testing;Thinness;Tissues;TNF gene;TNFRSF1A gene;TNFRSF1B gene;trafficking;Tumor Necrosis Factor Receptor;Tumor Necrosis Factor-Beta;Tumor Necrosis Factors

PROJECT_TITLE: Mechanisms that alter lymphatic transport in inflammatory bowel disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Lung;Pediatric;Pulmonary Hypertension

PHR: Project Narrative  Pediatric cardiac arrest affects thousands of children each year, and pulmonary hypertension among children with cardiac arrest is an understudied problem that is likely associated with worse survival outcomes. The objectives of this research are to define the epidemiology of pulmonary hypertension-associated cardiac arrest and to quantify its physiologic effects as well as the physiologic impact of a potential therapeutic, inhaled nitric oxide. These studies will form the foundation of our collective knowledge on this topic and will potentially lead to prospective clinical trials to improve outcomes from pediatric cardiac arrest.

PI_NAMEs: MORGAN, RYAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Accounting;Acidosis;Address;Adult;Affect;American Heart Association;Automobile Driving;Award;Blinded;Blood flow;Carbon Dioxide;Cardiac Output;Cardiopulmonary Resuscitation;career;career development;Characteristics;Chest;Child;Childhood;Circulation;Clinical;Clinical Data;clinical efficacy;clinical investigation;Clinical Research;Clinical Trials;Cohort Studies;Consensus;Coronary;coronary perfusion;Data;Dedications;design;Development Plans;Diastolic blood pressure;Disease;Dose;Echocardiography;Environment;Epidemiology;Epinephrine;Evaluable Disease;Event;experience;Foundations;Functional disorder;Funding;Goals;Guidelines;Heart Arrest;hemodynamics;Hospitalized Child;Hospitals;Hour;Hypertension;Hypoxemia;improved;improved outcome;indexing;Infrastructure;inhaled nitric oxide;insight;Intensive Care Units;International;Intervention Studies;Intervention Trial;Knowledge;Knowledge acquisition;Laboratories;Life;Lung;Mechanics;Mentors;observational cohort study;Outcome;patient oriented;patient response;Patients;Pediatric Hospitals;Pediatric Intensive Care Units;Pennsylvania;Pharmaceutical Preparations;Philadelphia;Physiological;Physiological Processes;Physiology;porcine model;pre-clinical;pressure;Prevalence;primary outcome;Process;professor;prospective;Prospective Studies;pulmonary arterial pressure;Pulmonary Hypertension;Pulmonary Vascular Resistance;Randomized;Recommendation;Records;Reporting;Research;Research Personnel;Resolution;response;Resuscitation;Science;Scientist;secondary outcome;Shock;skill acquisition;survival outcome;Survival Rate;System;Systemic blood pressure;Techniques;Therapeutic;therapy design;Time;Titrations;Universities;Vasoconstrictor Agents;Vasodilator Agents

PROJECT_TITLE: Pulmonary Hypertension-Associated Pediatric Cardiac Arrest

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Increasing mental health clinicians' use of evidence-based interventions (EBPs) is necessary to improve the quality of mental health care. This R01 takes advantage of large-scale rollouts of EBPs in Pennsylvania and Texas' publicly-funded mental health systems to test a promising causal model of EBP implementation that integrates constructs from social psychology and implementation science.

PI_NAMEs: HAIMES, EMILY MICHELE BECKER (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Address;Attitude;autism spectrum disorder;Behavior;behavior change;behavioral health;causal model;Client;Climate;clinical care;Cognitive;Cognitive Therapy;community setting;comparative;contextual factors;cost;cost effectiveness;Data;design;Development;Education;effective therapy;Effectiveness;effectiveness trial;Evidence based intervention;Evidence based practice;follow-up;Friction;Funding;Future;Goals;Health system;implementation determinants;implementation efforts;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Incentives;Individual;Intention;interest;Intervention;Interview;Link;Literature;Measures;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Motivation;multilevel analysis;National Institute of Mental Health;Pathway interactions;Pennsylvania;Philadelphia;Policies;Population;Predictive Factor;prospective;provider behavior;provider factors;psychologic;Psychological Factors;psychosocial;Psychotherapy;Public Health;Quality of Care;recruit;Reporting;Research;Resources;Sampling;Self Efficacy;Social Psychology;Special Education;Structure;Surveys;System;teacher;Testing;Texas;theories;Time;Training;United States National Institutes of Health;Validation;Work;Workload

PROJECT_TITLE: Validation of a Causal Model of Implementation

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Microbiome;Nutrition;Obesity;Prevention

PHR: The proposed research is relevant to public health because food specific molecular signatures and biomarkers of dietary consumption are needed to support clinical trials in nutrition research. Biomarkers based on carbohydrates will be obtained based on the structural analysis of carbohydrates in food and their respective products as the food interacts with human and bacterial enzymes that degrade polysaccharides into an array of potential biomarkers including microbial metabolites, monosaccharides, and oligosaccharides.

PI_NAMEs: LEBRILLA, CARLITO B (contact);LEMAY, DANIELLE GUYANNE;MILLS, DAVID ANDREW;SMILOWITZ, JENNIFER TRACY

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Amylases;Animals;Arabinose;Biological;Biological Markers;Biomarker of Dietary Intake;Bioreactors;carbohydrate database;carbohydrate structure;Carbohydrates;Clinical;Clinical Nutrition;Clinical Research;Clinical Trials;Complement;Consumption;Coronary heart disease;Data;Diet;dietary;Dietary Fiber;Dietary intake;Dietary Intervention;Digestion;Elements;Enrollment;Enzymes;Feces;feeding;Fermentation;Fiber;Food;Food Analysis;food consumption;Food Interactions;Freezing;fundamental research;Future;Gastrointestinal Diseases;Genes;genetic linkage analysis;Genetic Markers;German population;Goals;good diet;gut microbes;gut microbiome;gut microbiota;Health;Higher Order Chromatin Structure;Human;Infant;innovation;Intake;Libraries;Link;Measurement;Measures;metabolomics;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;microbiome;Modernization;Modification;molecular marker;Molecular Profiling;Monitor;Monosaccharides;multidisciplinary;multiple omics;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional Study;obesity risk;Oligosaccharides;Outcome;Plant Components;Polysaccharides;potential biomarker;predictive marker;Predictive Value of Tests;Public Health;Research;Resistance;Resolution;Role;Scientist;Source;Structure;Testing;Toddler;training opportunity;Travel;Volatile Fatty Acids;Weaning;Work

PROJECT_TITLE: Annotating carbohydrate structures to develop markers for consumption of food


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Human Genome;Lung;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: 10-15% of all monogenic inherited diseases are caused by mutations that result in premature termination codons (PTCs) mutations. Despite being a central mechanism in over 1,000 diseases, including cystic fibrosis, no current therapies exist. This proposal is designed to investigate the ability of suppressor tRNAs encoded in small DNA vectors delivered to lung to treat nonsense-associated cystic fibrosis and identify off-target suppression effects to determine their therapeutic promise.

PI_NAMEs: LUECK, JOHN D. (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Affect;airway epithelium;Amino Acids;Aminoglycosides;Anticodon;Bacterial Infections;Bar Codes;Biological Availability;Cell Culture Techniques;cell type;Cells;Charge;Chest;Chloride Channels;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Complementary DNA;Cultured Cells;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Data Set;design;Disease;DNA;DNA cassette;effective therapy;Effectiveness;effectiveness evaluation;efficacy testing;electric field;Electrophysiology (science);Electroporation;Engineering;Epithelial Cells;Exhibits;expression vector;Family suidae;Fluorescent in Situ Hybridization;Gene Delivery;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genome;Genomics;Goals;Hereditary Disease;Homeostasis;Human;Human Genetics;Immunofluorescence Immunologic;improved;In Vitro;in vivo;Inbred CFTR Mice;Infection;Length;Libraries;Liquid substance;loss of function;Lung;Maps;Measures;Mediating;Methods;Modeling;mRNA Expression;mRNA Transcript Degradation;Mucous body substance;Mus;mutant;Mutant Strains Mice;Mutation;nanoparticle;nephrotoxicity;Nonsense Mutation;Nonsense-Mediated Decay;novel;Nucleotides;ototoxicity;Persons;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Plasmids;porcine model;Positioning Attribute;premature;protein complex;protein function;Protein Truncation;Proteins;Quantitative Reverse Transcriptase PCR;Reporter;Reporter Genes;ribosome profiling;Safety;Site;small molecule;Specificity;Structure;Technology;Terminator Codon;Therapeutic;Tissues;Toxic effect;trafficking;Transcript;transcriptome;Transfer RNA;transgene expression;Translating;Translation Process;United States;vector;Viscosity;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: In vivo delivery of engineered tRNAs for suppression of nonsense mutations

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: The proposed research is relevant to public health because it focuses on developing a new drug delivery strategy to enable clinical translation of therapeutics that can prevent the progression of early osteoarthritis (OA). Once this platform is developed, there is a potential for a paradigm-shifting impact in OA therapy for active patients with early disease. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to reducing the illness and disability.

PI_NAMEs: JOSHI, NITIN  (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Address;amphiphilicity;anakinra;Animals;Biological;Biological Products;cathepsin K;clinical translation;Clinical Trials;Data;Degenerative polyarthritis;Development;disability;Disease;Drug Delivery Systems;drug efficacy;Drug Kinetics;drug release kinetics;Drug Stability;Encapsulated;Engineering;Enzymes;esterase;Esters;evidence base;Exhibits;fibroblast growth factor 18;Formulation;Future;Goals;healing;Human;Hydrogels;In Vitro;inhibitor;innovation;joint loading;Joints;Kinetics;Knee joint;Knowledge;Matrix Metalloproteinases;mechanical load;Mechanical Stress;Mechanics;Mission;Mus;novel;novel therapeutics;Outcome;overexpression;Pathology;Patients;Pharmaceutical Preparations;Preparation;prevent;Prevention;Process;Property;Public Health;Recovery;Reporting;Research;residence;Running;self assembly;small molecule;Solvents;System;Therapeutic;Therapeutic Effect;Time;tool;translational therapeutics;Translations;treadmill;Treatment Efficacy;United States National Institutes of Health;Variant;viscoelasticity

PROJECT_TITLE: A self-assembled hydrogel with tunable drug release kinetics for preventing osteoarthritis in active joints

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative: Addiction and other mental disorders arise from disruptions in brain circuitry important for natural reward processing and motivation. However, the precise cell types and circuits that control adaptive reward seeking remain poorly understood. The proposed experiments will continue to investigate the neurocircuit architecture and function of genetically defined cell types in the rodent lateral hypothalamic area to better understand circuity implicated in these disorders.

PI_NAMEs: STUBER, GARRET D (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Anatomy;Animal Feed;Animals;Appetitive Behavior;Architecture;Area;Behavioral;Brain;brain circuitry;Brain region;Calcium;Cell Physiology;cell type;Cells;Code;Communities;Consummatory Behavior;Consumption;Data;data resource;Data Set;Desire for food;differential expression;Disease;drug of abuse;Dynorphins;Electric Stimulation;Elements;experimental study;Fasting;feeding;Food;Foundations;Funding;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Glutamates;Goals;Habenula;Head;Hour;Hypothalamic structure;Image;Individual;insight;interdisciplinary approach;Lateral;Lateral Hypothalamic Area;Link;Mental disorders;Modification;Molecular;Molecular Profiling;Monitor;motivated behavior;Motivation;Mus;neural circuit;Neuroanatomy;Neurons;Neuropeptides;neuropsychiatric disorder;Neurotensin;novel;optogenetics;Organism;Output;parabrachial nucleus;Pathway interactions;Pharmacology Study;Play;Population;Process;Psychological reinforcement;Research;Resources;Response to stimulus physiology;reward processing;Rewards;Rodent;Role;Satiation;Seminal;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Somatostatin;Stimulus;Sucrose;Supporting Cell;Surveys;temporal measurement;Testing;Thalamic structure;Therapeutic Intervention;tool;two-photon;Ventral Tegmental Area;Ventricular;Viral;Work

PROJECT_TITLE: Lateral Hypothalamic Circuits for Feeding and Reinforcement

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because discovery of B cell responses to peripheral nerve injury is ultimately expected to increase understanding of the mechanisms of peripheral neuropathic pain in humans, and offer new pharmacological targets. Thus, the proposed research is relevant to the mission of NINDS, as it will uncover fundamental knowledge of nervous system dysfunction after injury as a means to reduce the burden of peripheral neuropathic pain.

PI_NAMEs: GRACE, PETER M (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Antibodies;Antigen-Antibody Complex;Antigen-Presenting Cells;Apoptosis;Apoptotic;Attenuated;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Process;B cell differentiation;B-Cell Activation;B-Lymphocytes;Biochemical;Biochemistry;Biological;Biological Assay;cell injury;Cell secretion;Cells;Central Nervous System;Cerebrospinal Fluid;Complex;Cytoprotection;Data;Deposition;Disease;Docking;dorsal horn;effective therapy;Female;Flow Cytometry;Functional disorder;Genetic;genetic manipulation;Goals;Human;humoral immunity deficiency;IgG Receptors;Immunoglobulin G;Immunologist;In Situ Hybridization;Induction of Apoptosis;Injury;innovation;interdisciplinary approach;Knock-out;Knowledge;Link;Maintenance;male;Measures;Microscopy;Mission;Molecular;Monitor;mouse model;Mus;National Institute of Neurological Disorders and Stroke;Necrosis;nerve injury;Nervous System;Neuroimmune;Neutrophil Infiltration;Nociception;Pain;pain behavior;pain signal;painful neuropathy;Patients;Pattern;Peripheral;Peripheral nerve injury;pharmacologic;plasma cell differentiation;Plasma Cells;porcine model;Public Health;Radiculopathy;receptor;Receptor Signaling;Reflex action;Regulation;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;Site;Solid;Spinal;T-Cell Activation;Tail;Techniques;Testing;Therapeutic Intervention;therapeutic target;Time;transcriptome;validation studies

PROJECT_TITLE: Regulation of Peripheral Neuropathic Pain by B Cells

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative The identification of cellular and molecular mediators of repair following demyelination is critical to developing therapies and drugs to ameliorate the progressive disability in patients with multiple sclerosis (MS). The proposed research is relevant to public health because of the novel link between circadian disruption, a common problem associated with MS patients, and the process of failed repair in MS. The proposed research is relevant to the mission of the NINDS because it will develop fundamental knowledge that may help reduce the burden of disease and improve the quality of life for MS patients.

PI_NAMEs: DUTTA, RANJAN  (contact);RAO, SUJATA

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Address;Affect;Animal Model;ARNTL gene;Autopsy;Biology;Brain;brain tissue;burden of illness;Cell Lineage;Cell Physiology;Cells;Central Nervous System;chronic demyelination;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;combinatorial;Cuprizone;Darkness;Data;Defect;Demyelinations;disability;Disease;Disease Management;Disease Progression;Drug Side Effects;Drug usage;Event;experience;Failure;Fatigue;Frequencies;Future;General Population;Genes;Genetic Polymorphism;Goals;Human;illness length;improved;inflammatory milieu;innovation;Knowledge;Lead;Lesion;Light;Link;Magnetic Resonance Imaging;Mediating;Mediator;Mission;Molecular;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;National Institute of Neurological Disorders and Stroke;Nervous System control;Nervous System Physiology;Neurologic Deficit;novel;novel therapeutics;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathology;Patients;Pharmaceutical Preparations;precursor cell;prevent;Process;Public Health;Quality of life;reduce symptoms;remyelination;repaired;Research;Role;Sampling;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep pattern;Specificity;stem;stem cells;Testing;Therapeutic;therapeutic target;therapy development;Tissue Model;Transcriptional Regulation;Work

PROJECT_TITLE: Understanding role of circadian disruption in pathogenesis of MS

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

PHR: Developmental prosopagnosia (DP), a disorder in which individuals have severe lifelong face recognition deficits, affects up to 2.5% of the population and currently has no treatment. We have found preliminary evidence of meaningful perceptually-impaired vs. perceptually-unimpaired DP subgroups and propose to further test and validate these subgroups in a large sample, examine the neural mechanisms of DP perceptual deficits, and also test whether DP subgroups differentially respond to cognitive training treatments targeting face perception vs. face memory. This could not only help developmental prosopagnosics but potentially other disorders with face processing deficits.

PI_NAMEs: DEGUTIS, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Affect;Alzheimer's Disease;Anger;Area;autism spectrum disorder;Behavior;behavior test;Behavioral;Cognitive;cognitive training;Collection;comparison control;computerized;Computers;Data;Depressed mood;Development;developmental prosopagnosia;Diffusion Magnetic Resonance Imaging;Disease;DSM-V;Electroencephalography;Emotions;Employment;Event-Related Potentials;Eye;Face;face perception;Face Processing;Fright;Functional Magnetic Resonance Imaging;Goals;Grouping;Heterogeneity;Impairment;improved;Individual;individualized medicine;Learning;Longevity;Longitudinal Studies;Measures;Memory;Memory impairment;Mission;National Eye Institute;neural;neuromechanism;novel;Online Systems;Oral cavity;Patient Self-Report;Perception;Pilot Projects;Population;Population Decreases;receptive field;recruit;Research;response;sample fixation;Sample Size;Sampling;Schizophrenia;social anxiety;Subgroup;Testing;Training;Training Programs;treatment response;trend;Validation;Vision;Vision Disorders;Visual;Waiting Lists;white matter

PROJECT_TITLE: Developmental prosopagnosia subtypes: validation, neural mechanisms, and differential approaches to treatment

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Public Health Relevance Jamaican sexual and gender minorities comprise between 27,000 to 33,000 individuals who are at risk for health disparities, including very high rates of HIV and mental health conditions. Violence against Jamaican sexual and gender minorities is also a key driver fueling the high prevalence of HIV infections in this population by driving them underground and away from vital HIV prevention and treatment services. This program of research provides a supportive, innovative strengthens-based approach to improve HIV care engagement among Jamaican sexual and gender minorities by targeting intersectional stigma and violence, both of which have a negative impact on mental health and engagement in care. We will look at the interplay between intersectional stigma and violence, within the Caribbean context, for the first time among sexual and gender minorities living with HIV and develop a supportive behavioral intervention that takes into account the complex, multi-layered lives sexual and gender minority Jamaicans inhabit.

PI_NAMEs: HARRIS, ORLANDO OMAR (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Advocacy;Affect;AIDS prevention;Anti-Retroviral Agents;Anxiety;Appointment;Automobile Driving;Behavior Therapy;care outcomes;Caribbean region;Caring;Clinic;Clinical;clinical research site;cognitive interview;Communities;Complex;Consult;Cross-Sectional Studies;Data;design;Development;Discrimination;Disparate;Disparity;Drops;Educational workshop;Eligibility Determination;Epidemic;Evaluation;experience;feasibility testing;Feedback;Focus Groups;gender affirmation;General Population;global health;Goals;Grant;harassment;Health;Health behavior change;health disparity;Health Personnel;High Prevalence;HIV;HIV Infections;HIV/AIDS;Homo;Human Rights;Immunologics;implementation barriers;implementation facilitators;improved;indexing;Individual;innovation;insight;instrument;intersectionality;Intervention;intervention mapping;Intervention Trial;Interview;Jamaica;Jamaican;K-Series Research Career Programs;Knowledge;Laws;longitudinal analysis;low and middle-income countries;male;Manuals;marginalization;Measurement;Measures;Medical;meetings;men who have sex with men;Mental Depression;Mental Health;Mentors;Mentorship;Methods;Modeling;Nurses;Outcome;Participant;Pathway interactions;patient health information;Patient Self-Report;perceived discrimination;Personal Satisfaction;Persons;pilot test;Policies;Policy Maker;Population;Positioning Attribute;Prevalence;Prevention;prevention service;programs;Property;Provider;Psychologist;Psychology;Psychometrics;public health relevance;racism;Randomized;randomized trial;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Resource-limited setting;Resources;Risk;Same-sex;Scientist;Services;Sex Behavior;Sexual and Gender Minorities;Sexual Health;Sexuality;skills;social health determinants;social stigma;social structure;Social Workers;sodomy;success;Surveys;Sustainable Development;Symptoms;System;Target Populations;Testing;theories;Theory of Change;therapy design;therapy development;Time;Training;Training Activity;transgender women;transphobia;Trauma;Treatment outcome;treatment services;United Nations;United States;Violence;Viral;Viral Load result

PROJECT_TITLE: Jamaica CARES Project: Connecting HIV/AIDS Resources to Engage Jamaican Sexual and Gender Minorities


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Palliative Care;Prevention;Rural Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PI_NAMEs: ZUBKOFF, LISA  (contact)

PROGRAM_OFFICER_NAME: CASTRO, KATHLEEN M

PROJECT_TERMS: Address;Adopted;Adoption;Advanced Malignant Neoplasm;Alabama;American Cancer Society;American Society of Clinical Oncology;cancer care;Cancer Center;Cancer Patient;care systems;caregiver quality of life;Caregivers;Caring;Client;Clinic;Clinical;cluster randomized design;Cluster randomized trial;Community Clinical Oncology Program;comparative trial;compare effectiveness;Data Reporting;Diagnosis;disparity reduction;Disseminated Malignant Neoplasm;E-learning;effective therapy;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation trial;evidence base;Evidence based practice;Feedback;Funding;Goals;Guidelines;health care availability;Health system;Healthcare;Healthcare Systems;Hybrids;implementation barriers;implementation outcomes;implementation process;implementation research;implementation strategy;implementation trial;improved;improved outcome;intervention program;Knowledge;Learning;Life;Measures;Methods;Minority;Modeling;Moods;National Cancer Institute;Newly Diagnosed;Oncology;Online Systems;Outcome;Palliative Care;Patient-Focused Outcomes;Patients;Population;Problem Solving;Procedures;Proctor framework;programs;Public Health;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reproducibility;Research;Research Design;Research Institute;response;Rural;rural dwellers;Services;South Carolina;success;Symptom Burden;telehealth;Testing;Training;treatment planning;uptake;virtual;Work

PROJECT_TITLE: Implementing Palliative Care: Learning Collaborative vs. Technical Assistance