NIH_SPENDING_CATS: Biotechnology;Clinical Research;Lung;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Pulmonary Hypertension

ORG_DEPT: PEDIATRICS

PHR: Project Narrative Pulmonary hypertension (PH) induced by hypoxia is a debilitating disease that affects premature infants with bronchopulmonary dysplasia and adults with chronic obstructive lung disease. We showed that genetic activation of Fibroblast Growth Factor (FGF) signaling in lung endothelial cells is protective against hypoxia-induced PH. This proposed studies will increase our understanding of the role of FGF in vascular remodeling, as well as advance gene therapy approaches to activate FGF signaling efficiently and selectively in the pulmonary vascular endothelium.

PI_NAMEs: WOO, KELVIN  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: adenovirus mediated delivery;Adenovirus Vector;Adenoviruses;Adult;Affect;angiogenesis;authority;Biology;biomarker identification;Blood Vessels;Bronchopulmonary Dysplasia;Cardiopulmonary;career development;Cell Communication;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Classification;Collaborations;collaborative environment;conditional knockout;Cytoprotection;Data;Development;Development Plans;Disease;disease model;Distal;early detection biomarkers;Endothelial Cells;Endothelium;Engineering;experience;Exposure to;Extramural Activities;Fellowship;FGFR1 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;gain of function;Gene Delivery;gene therapy;Genetic;Genetic Models;Goals;hemodynamics;Hypoxemia;Hypoxia;hypoxia-induced pulmonary hypertension;improved;improved outcome;in vivo;Innovative Therapy;Knockout Mice;Knowledge;Laboratories;Ligands;loss of function;Lung;Lung Diseases;lung microvascular endothelial cells;medical schools;Mentorship;Mesenchymal;Methods;Mission;Modeling;Molecular;Morbidity - disease rate;mortality;mouse genetics;Mus;Muscle;National Heart, Lung, and Blood Institute;new therapeutic target;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Pediatric cardiology;Phenotype;Physicians;Physiological;Pre-Clinical Model;premature;Premature Infant;prevent;Principal Investigator;Production;Productivity;Proliferating;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;Regulation;Research;Research Personnel;Resources;response;Role;Scientist;Severities;Signal Pathway;Signal Transduction;skill acquisition;skills;Smooth Muscle;Smooth Muscle Myocytes;Stress;Structure of parenchyma of lung;Techniques;Therapeutic;Therapeutic Intervention;therapeutic target;tissue injury;tool;Training;Training Programs;Transforming Growth Factor beta;translational approach;United States National Institutes of Health;Universities;Vascular Endothelial Cell;Vascular Endothelium;Vascular remodeling;Vascular Smooth Muscle;Washington;Work

PROJECT_TITLE: The protective role of fibroblast growth factor signaling in hypoxia-induced pulmonary hypertension

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Chicago

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Severe infections and inflammation of the lung leads to build-up of fluid in the lung, resulting the devastating Acute Respiratory Distress Syndrome (ARDS), in which patients have to be placed on ventilators and for which there are no effective treatments. We have found that lung blood vessel endothelial cells can function as immune cells and are essential to the development of the disease. By understanding this newly recognized function of lung endothelial cells, this Program Project will identify molecules that can be targeted for the development of new ARDS treatments.

PI_NAMEs: MEHTA, DOLLY  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adherens Junction;AKT1 gene;Alveolar;alveolar epithelium;Angiopoietin-2;Area;Arteries;Automobile Driving;Bacterial Infections;Biogenesis;Blood;Blood Vessels;Brain;cadherin 5;Calcium Signaling;Cause of Death;Cell Adhesion;Cell membrane;Cells;cellular imaging;checkpoint modulation;Collaborations;Complex;court;COVID-19 pandemic;Cues;Data;Defense Mechanisms;Development;Disease;Disease Progression;Edema;effective therapy;Endoplasmic Reticulum;Endothelial Cells;endothelial regeneration;Endothelium;Environment;Epigenetic Process;Exposure to;formyl peptide;Foundations;FOXO1A gene;Gene Expression Regulation;Generations;Genetic Transcription;Goals;Health;Heart;Homeostasis;Host Defense;Human;Image;Immune;immune activation;immune function;Immune response;Immune system;Immunity;Immunoglobulin binding proteins;immunoregulation;Impairment;Infection;Inflammation;Inflammatory;inflammatory lung disease;Injury;innate immune function;Innate Immune Response;Innate Immune System;innovation;inorganic phosphate;intravital imaging;Leadership;Leukocytes;Ligation;Liquid substance;Lung;lung imaging;lung injury;lung microvascular endothelial cells;lung repair;Mediating;Membrane;Metabolism;migration;Mitochondria;mitochondrial dysfunction;monolayer;mortality;Mus;Natural regeneration;neutrophil;new therapeutic target;novel;Organ;Organelles;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phosphotransferases;Physiology;PINK1 gene;Population;prevent;Process;programs;Proteins;pulmonary function;Pulmonary Inflammation;receptor;Regulation;Resolution;Respiratory Failure;response;restoration;Ring Finger Domain;Role;Signal Pathway;Signal Transduction;spatiotemporal;success;Supportive care;Surface;synergism;targeted treatment;Tennis;Testing;Time;trafficking;transcriptome sequencing;transcriptomics;Trauma;two-photon;ubiquitin-protein ligase;Ubiquitination;ultra high resolution;Up-Regulation;Variant;vascular injury;Veins;Ventilator;Virus Diseases;Work

PROJECT_TITLE: The Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular Injury

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


PHR: Not applicable to the Administrative Core.

PROJECT_TERMS: Accounting;Advisory Committees;Budgets;Collaborations;Elements;Endothelium;Expenditure;Fostering;Grant;Innate Immune System;Lung;meetings;programs;Progress Reports;Universities;vascular injury;Visit

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PHR: Not applicable to individual projects and cores.

PI_NAMEs: CHRONIS, KONSTANTINOS  (contact)

PROJECT_TERMS: analytical tool;Anti-Inflammatory Agents;ATAC-seq;Biogenesis;Bioinformatics;Biological Assay;Biological Response Modifiers;Biometry;Blood Cells;Blood Vessels;Cell Count;Cell Physiology;Cell surface;Cells;ChIP-seq;Chromatin;comparative;Coupled;Data;Data Analytics;Data Files;data integration;Data Set;data sharing;Data Storage and Retrieval;Development;Dimensions;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Environment;Epigenetic Process;epigenomics;Event;Foundations;Gene Expression;gene network;gene regulatory network;Generations;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Genomics;Goals;Grant;Homeostasis;Immune;Immune signaling;Individual;Infection;Inflammation;Inflammatory Response;Injury;injury and repair;Innate Immune System;Investigation;Libraries;Lung;lung injury;lung repair;Maps;Methodology;Methods;Mining;Mitochondria;Modeling;Molecular;Natural Immunity;Neutrophil Activation;next generation sequencing;Organ;Pathway interactions;Phagocytes;Preparation;Process;Production;programs;Pulmonary Circulation;pulmonary function;repair model;Reproducibility;Resolution;response;Role;Sampling;Scanning;Signal Induction;Signal Pathway;Signal Transduction;Sphingosine-1-Phosphate Receptor;Standardization;stem cells;System;Technology;Testing;transcriptome sequencing;transcriptomic profiling;transcriptomics;ubiquitin-protein ligase;Validation;vascular injury

PROJECT_TITLE: Epigenetics and Transcriptomics Core


NIH_SPENDING_CATS: Lung

PI_NAMEs: MO, GARY CH (contact)

PROJECT_TERMS: Address;Binding;Biochemical;Biochemical Process;Biological Response Modifiers;Biosensing Techniques;Blood Vessels;cadherin 5;Calcium;Calcium Channel;Categories;Cell membrane;Cell Surface Receptors;Cells;cellular imaging;combinatorial;Complex;Data Analyses;depolymerization;Development;Diffusion;endoplasm;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Event;experimental study;Fluorescence Resonance Energy Transfer;Goals;Grain;Image;Immune;immune function;Immune signaling;immunoreaction;In Vitro;in vivo evaluation;in vivo imaging;Individual;Inflammatory;Injury;injury and repair;Innate Immune System;insight;intravital imaging;Link;Lung;Lysine;Mediating;Membrane;Membrane Proteins;Methodology;Methods;Microscopy;Molecular;Molecular Chaperones;Monitor;novel;novel strategies;Phagocytes;Physiology;Play;programs;protein degradation;protein protein interaction;Protein translocation;Proteins;pulmonary function;Reagent;Receptor Cell;Receptor Signaling;Regulation;Resolution;response;Role;Second Messenger Systems;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;single molecule;small molecule;spatiotemporal;Sphingosine-1-Phosphate Receptor;success;superresolution microscopy;Techniques;Testing;Time;tool;Training;Tyrosine Phosphorylation;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;ultra high resolution;Vascular Endothelial Cell;vascular injury;Visual;Visualization

PROJECT_TITLE: Cellular Imaging Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hematology;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative: Racial disparities in the use of OAC in patients with NVAF are notable given the increased risk of stroke and death in Blacks with NVAF. Shared decision making is guideline indicated by cardiovascular professional organizations for discussions about the risk and benefits of OAC, but it is less likely to occur in Blacks with NVAF. This research will identify barriers and facilitators to shared decision making, develop a patient decision support tool to assist in facilitating shared decision making with the goal of improving decision quality, increasing OAC use among Blacks and decreasing disparities in OAC use between Blacks and Whites.

PI_NAMEs: JACKSON, LARRY R (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Anticoagulants;Anticoagulation;Arrhythmia;Atrial Fibrillation;Award;Awareness;Benefits and Risks;Biomedical Research;black patient;Black Populations;Black race;Cardiac;Cardiology;Cardiovascular system;care outcomes;career;Caring;Cessation of life;Clinic;Clinical;clinical practice;Clinical Trials Design;Communication;Competence;Conflict (Psychology);Consent;Counseling;Data;Decision Making;design;Development;Diagnosis;Disabling;Disease;disparity reduction;Education;effectiveness testing;efficacy evaluation;efficacy testing;empowerment;Ensure;ethnic minority;ethnic minority population;Ethnic Population;evidence base;Evidence based intervention;experience;Faculty;feasibility testing;Feedback;Future;Goals;Guidelines;health care delivery;health care disparity;health care quality;Health system;Healthcare;Heart Abnormalities;heart rhythm;implementation science;improved;improved outcome;Intervention;Interview;Ischemic Stroke;K-Series Research Career Programs;Knowledge;low health literacy;Measures;medical schools;Medicine;Mentors;Oral;Outcome;Outcome Measure;patient oriented;Patient Preferences;Patient-Centered Care;patient-clinician communication;Patients;Perception;Physicians;Pilot Projects;Primary Care;Primary Care Physician;primary outcome;Process;Productivity;Professional Organizations;professor;Provider;Psychologist;Qualifying;Questionnaires;Race;racial disparity;racial minority;racial minority population;racial population;randomized trial;randomized, clinical trials;Research;Research Personnel;Research Proposals;Risk;Risk Reduction;Role;Sampling;satisfaction;Scientist;shared decision making;Site;skills;social;Stroke;Stroke prevention;stroke risk;Structure;support tools;Testing;Therapeutic Intervention;tool development;Training;United States;Universities;uptake;Work

PROJECT_TITLE: Shared Decision-Making to Reduce Racial Disparities in Oral Anticoagulation Use in Patients with Non-Valvular Atrial Fibrillation


NIH_SPENDING_CATS: Biomedical Imaging;Lung

PI_NAMEs: TSUKASAKI, YOSHIKAZU  (contact)

PROJECT_TERMS: Algorithms;Animals;Biogenesis;Blood Cells;Blood Vessels;cadherin 5;Cell Physiology;Cell Surface Receptors;Cells;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Image;imaging approach;imaging study;Immune;In Situ;in vivo;in vivo imaging;Individual;Inflammatory;Injury;injury and repair;innate immune function;Innate Immune System;interest;intravital imaging;Lung;lung imaging;lung injury;lung repair;Macrophage;Measures;Methods;migration;Mitochondria;Molecular;Monitor;monocyte;Morphologic artifacts;Motion;mouse model;Mus;Myeloid Cells;neutrophil;novel;novel strategies;Outcome;Pathway interactions;Permeability;Phagocytes;Phagocytosis;Phase;Phenotype;Phosphorylation;Physiological;Physiology;programs;Pseudomonas aeruginosa;Regulation;Resolution;respiratory;response;Ring Finger Domain;Role;Signal Transduction;spatiotemporal;Sphingosine-1-Phosphate Receptor;success;trafficking;two-photon;ubiquitin-protein ligase;Vascular Endothelium;vascular injury;Visual

PROJECT_TITLE: Intravital Imaging and Physiology Core


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Hematology;Prevention;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative: Immune thrombotic thrombocytopenic purpura (iTTP) is a potentially devastating hematologic disorder associated with significant morbidity and mortality. There is a need for improved treatments and for better diagnostic testing to identify patients at increased risk of disease relapse. This proposal will address the autoantibody-mediated pathophysiology of iTTP towards identifying novel strategies for the clinical management of the disease.

PI_NAMEs: HALKIDIS, KONSTANTINE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Advisory Committees;Affect;Affinity;Agglutination;Agreement;Antibodies;Area;Autoantibodies;Autoimmune;Binding;Binding Sites;Biological Assay;Blood Platelets;Blood Vessels;career;career development;Cell Therapy;cleavage factor;Clinic;Clinical;Clinical Management;Coupled;Data;Deuterium;Development Plans;Diagnostic;Diagnostic tests;Disease;Disease Management;Disintegrins;disorder risk;Distal;Endothelium;enzyme activity;Enzyme Inhibition;Enzymes;Epitopes;Functional disorder;Goals;Hematologic Neoplasms;Hematological Disease;Human;human monoclonal antibodies;Hydrogen;IgG autoantibodies;Immune;Immunodiagnostics;Immunoglobulin G;Immunotherapy;improved;in vitro activity;in vivo;in-vitro diagnostics;Individual;Informal Social Control;inhibiting antibody;inhibitor;insight;Internal Medicine;Kansas;Life;Mass Spectrum Analysis;Mediating;Medical center;meetings;Mentors;Metalloproteases;Molecular;Molecular Conformation;Monoclonal Antibodies;Morbidity - disease rate;mortality;Non-Neoplastic Hematologic and Lymphocytic Disorder;novel diagnostics;novel strategies;novel therapeutic intervention;Organ;Outcome;Pathogenesis;Patients;Phage Display;Physicians;Physiological;Plasma;Plasmapheresis;prevent;Process;professor;Prognosis;Recurrent disease;Research;Research Personnel;Role;Scientist;Site;Source;Specificity;structural biology;Structure;Techniques;Temperature;tenure track;Tertiary Protein Structure;Testing;Therapeutic Agents;Therapeutic Intervention;Thrombosis;Thrombospondins;thrombotic;Thrombotic Thrombocytopenic Purpura;Time;Training;Translating;Universities;von Willebrand Factor;Work

PROJECT_TITLE: Exploring the mechanisms of action of anti-ADAMTS 13 antibodies in immune thrombotic thrombocytopenic purpura


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Lung;Rare Diseases

PROJECT_TERMS: Acute Lung Injury;Address;Anti-Inflammatory Agents;Area;Bacterial Infections;Binding;Blood Vessels;Calcium;Cell Differentiation process;Cell surface;Cells;cellular imaging;Chromatin;cytokine;Data;Development;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Epigenetic Process;epigenome;Event;G-Protein-Coupled Receptors;Gases;Gene Modified;Genes;GTP-Binding Proteins;Homeostasis;IGBP1 gene;Immune;immune activation;Immunoglobulin binding proteins;Immunoglobulins;Immunologic Markers;Immunologics;Individual;Infection;Inflammation;Inflammatory;Injury;innate immune function;Innate Immune System;Knock-in;Knockout Mice;Leukocytes;Ligation;Lung;lung imaging;Lung infections;lung injury;Mediating;Mediator;Membrane;Modeling;Modification;Molecular;Molecular Chaperones;mouse model;Mus;mutant mouse model;Myeloid Cells;novel;novel marker;Phenotype;Phosphorylation;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;programs;Protein Tyrosine Kinase;Proteins;Pseudomonas;Pseudomonas aeruginosa;receptor;Receptor Activation;Receptor Signaling;recruit;Resolution;Role;Signal Transduction;Signaling Protein;Site;Sphingosine-1-Phosphate Receptor;Surface;Testing;Tissues;TNF gene;tool;transcriptome;two-photon;Tyrosine;ultra high resolution;Vascular Endothelium;vascular injury;Virus Diseases

PROJECT_TITLE: S1PR1 Mislocalization in Lung Endothelium Regulates Innate Immune Function and Mediates Inflammatory Lung Injury


PI_NAMEs: MALIK, ASRAR B. (contact)

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Address;Adherens Junction;AKT1 gene;Angiopoietin-2;bactericide;Binding;Biochemical;Biological Assay;Blood Vessels;cadherin 5;Cell Communication;Cell surface;Cells;cellular imaging;Data;defense response;Down-Regulation;Edema;Endocytosis;Endothelial Cells;Endothelium;Event;Failure;FOXO1A gene;Gatekeeping;Generations;Genetic;Genetic Transcription;Host Defense;Host Defense Mechanism;Human;in vivo;Individual;Inflammation;Inflammatory;Injury;innate immune function;Innate Immune Response;Innate Immune System;intravital imaging;Knockout Mice;Life;Link;Lung;Lung immune response;lung injury;macromolecule;Mediating;Mediator;Methods;migration;Molecular;mouse model;Mus;Natural Immunity;neutrophil;new therapeutic target;Nodal;novel;novel strategies;novel therapeutic intervention;Nuclear Translocation;pathogen;Pathogenicity;Pathway interactions;Permeability;Phagocytes;Phagocytosis;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiology;Plasma;Polyubiquitin;prevent;Process;Protac;protein degradation;Proteins;Pseudomonas aeruginosa;Pulmonary Edema;pulmonary function;Respiratory Failure;response;Ring Finger Domain;Role;Secondary to;Signal Pathway;Signal Transduction;superresolution microscopy;Testing;TIE-2 Receptor;Time;Tissues;TLR4 gene;transcription factor;transcriptomics;ubiquitin-protein ligase;Up-Regulation;Vascular Endothelial Cell;vascular endothelial protein tyrosine phosphatase;vascular injury

PROJECT_TITLE: E3 Ubiquitin Ligase CHFR Regulates Lung Endothelial Barrier Integrity and Innate Immunity through Control of VE-cadherin Expression


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Immunization;Lung;Lung Cancer;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Urologic Diseases;Vaccine Related;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative We will develop and efficiently complete novel early phase cancer prevention clinical trials of vaccines, signaling inhibitors, and immune-modulating drugs by enhancing patient accrual through effective use of social media and mobile messaging. The results of these trials will contribute to our basic understanding of the critical role of the immune system and molecular signaling pathways in tumorigenesis, thus helping to reduce cancer incidence and mortality and promote public health by advancing cancer prevention drug development.

PI_NAMEs: VILAR SANCHEZ, EDUARDO  (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Advanced Malignant Neoplasm;Antigens;Applications Grants;Aromatase Inhibitors;Aspirin;Bioinformatics;Biological Markers;Bladder;Breast;Breast Cancer Prevention;Budesonide;cancer prevention;Cancer Prevention Intervention;Cancer Prevention Trial;Cause of Death;Cessation of life;Clinical;Clinical Chemoprevention;Clinical Research;clinical trial recruitment;Clinical Trials;Colon Carcinoma;Colorectal Cancer;Colorectal Neoplasms;Conduct Clinical Trials;Coupled;Critical Pathways;Death Rate;Development;Disease;disorder risk;DNA;Dose;Dropout;drug development;drug efficacy;Early Diagnosis;early phase clinical trial;early phase trial;eHealth;Electronics;Eligibility Determination;eligible participant;Endometrial Neoplasms;Enrollment;Epigallocatechin Gallate;Exemestane;experience;Facebook;Formulation;Future;Goals;Green tea;Head and Neck Cancer;Hematology;Hereditary Neoplastic Syndromes;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;high risk population;High-Risk Cancer;immune cell infiltrate;immune modulating agents;Immune response;Immune system;immunoregulation;improved;Incidence;Individual;Inhalation;inhibitor;International;Intervention;Lesion;Lung;Malignant neoplasm of esophagus;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammary Gland Parenchyma;Methods;Modification;Molecular;Molecular Analysis;mortality;mTOR inhibition;mTOR Inhibitor;Naproxen;neoantigens;news;Non-Steroidal Anti-Inflammatory Agents;novel;novel strategies;novel therapeutics;Participant;participant retention;Pathologist;Pathway interactions;patient retention;Patients;Peptides;Pharmaceutical Preparations;Pharmacotherapy;Phase;phase 3 testing;phase I trial;phase II trial;Phase II/III Trial;phase III trial;premalignant;prevent;Prevention;prevention clinical trial;Prevention strategy;Prevention trial;Preventive;preventive intervention;Preventive therapy;Preventive vaccine;programs;Prostate;Public Health;Recording of previous events;recruit;Research Personnel;response;Risk;Role;Safety;safety assessment;safety testing;Sampling;Schedule;screening;SDZ RAD;Series;side effect;Signal Pathway;Signal Transduction;social media;Social Network;Steroids;Stomach Neoplasms;Testing;tissue biomarkers;translational scientist;triple-negative invasive breast carcinoma;Tumor Promotion;tumorigenesis;Twitter;United States;Update;Vaccine Clinical Trial;Vaccine Therapy;Vaccines;Visit;Woman;Zileuton

PROJECT_TITLE: iCAN-PREVENT: MD Anderson International Cancer Prevention Clinical Trial Consortium


NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative The Summer Program to Increase Diversity in Biomedical Research and the Physician Workforce encompasses two training initiatives designed to enhance the training experience of underrepresented minority and disadvantaged students who are interested in pursuing careers in medicine and research. The program for undergraduates is entitled “The Pritzker School of Medicine Experience in Research (PSOMER),” while the medical school program supports the participation of rising second year medical students in the Pritzker Summer Research Program (SRP). The goal is to provide strongly mentored summer experiences in research, as well as structured programming and mentoring that will encourage students to progress into medicine and biomedical research careers.

PI_NAMEs: OLOPADE, CHRISTOPHER O (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Admission activity;Appointment;Area;Articulation;Award;Biomedical Research;Cardiovascular Diseases;career;Career Choice;career development;Chicago;Clinical;clinical investigation;cohort;Cost Sharing;Data;design;Development;Diagnosis;disadvantaged background;disadvantaged student;Disparity population;Doctor of Philosophy;economic disparity;Effectiveness;Environment;Ethics;ethnic disparity;Ethnic Population;experience;experimental study;Exposure to;Faculty;Formulation;Fostering;Foundations;Funding;Future;Goals;Grant;Hematological Disease;human disease;Individual;Institution;interest;Investigation;Learning;Lung Diseases;matriculation;Medical;Medical Education;medical schools;Medical Students;Medicine;member;Mentors;Methods;Mission;Modernization;National Heart, Lung, and Blood Institute;Oral;Paper;Participant;peer;Physicians;Preparation;programs;Publishing;Qualifying;Questionnaires;racial disparity;racial population;Reporting;Research;Research Personnel;Research Support;Research Training;Resources;responsible research conduct;Role;Scholarship;Science;Scientist;Sleep Disorders;socioeconomic disadvantage;Structure;Students;success;summer program;summer research;Techniques;Time;Training;Training Programs;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States;Universities;university student;Writing

PROJECT_TITLE: Summer Program to Increase Diversity in Biomedical Research & Physician Workforce - Renewal 01


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine

PI_NAMEs: REHMAN, JALEES  (contact)

PROJECT_TERMS: Acute;Address;Affect;Bacterial Proteins;beta catenin;Binding;Biogenesis;Biosensor;Blood Vessels;Brain;Cardiovascular Diseases;Cell Death;Cell Nucleus;cell regeneration;Cells;Cellular Metabolic Process;chemokine;Chronic Disease;Coupled;cytokine;Data;Disease Outcome;Electron Transport;Endothelial Cells;endothelial regeneration;Endothelium;Enzymes;Epigenetic Process;Equilibrium;fMet-Leu-Phe receptor;formyl peptide;Functional disorder;Gene Expression Profile;Generations;Genes;Genetic;Genetic Induction;Genetic Models;Heart;Homeostasis;Host Defense;Human;Image;Immune;In Vitro;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Injury;Innate Immune Response;Innate Immune System;Interferon Type I;Knock-out;Leukocytes;Lung;lung injury;Mammalian Cell;Mediator;Metabolism;Methionine;migration;Mitochondria;mitochondrial autophagy;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Mus;Natural regeneration;neutrophil;Nuclear;Nuclear Proteins;Paracrine Communication;Parkin;Pattern;Peptides;Phagocytosis;Phase;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;PINK1 gene;Play;Pneumonia;Production;Protein Kinase;Proteins;Pseudomonas;Reactive Oxygen Species;recruit;Regulation;Regulator Genes;response;restoration;Role;Signal Pathway;Signal Transduction;Site;T-Lymphocyte;Testing;TNF gene;transcription factor;transcriptomics;Translations;translatome;two-photon;ubiquitin ligase;Ubiquitination;vascular injury

PROJECT_TITLE: Mitochondrial Dysfunction in the Endothelium as a Mediator of Inflammatory Injury


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: GENETICS

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE A unique epigenetic state called bivalency exists in germ cells and embryonic stem cells at promoters of developmental genes, but little is known about the mechanisms that establish bivalency and the functional contributions of the bivalent state to germ cell function, fertilization, and embryonic development. This project will address this gap in understanding by investigating the specific sequence elements that drive establishment of bivalency and identifying novel candidates responsible for regulating this unique histone modification state. This research will advance our basic understanding of how chromatin state is regulated and provide insight into new factors that may affect fertility and congenital disease.

PI_NAMEs: MARSHALL, KIRA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Ablation;Affect;Binding Sites;candidate identification;CCCTC-binding factor;Cell Differentiation process;Cell Physiology;Cell Separation;Cells;Cellular biology;Chromatin;Conserved Sequence;CpG Islands;CRISPR screen;CRISPR/Cas technology;Data;design;Development;Developmental Gene;developmental plasticity;Disease;DNA;Elements;Embryo;Embryonic Development;embryonic stem cell;Epigenetic Process;Equilibrium;ES Cell Line;Exhibits;experimental study;Fertility;Fertilization;Flow Cytometry;Foundations;Future;Gene Expression;gene repression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genome;genome-wide;Germ Cells;Germ Lines;Goals;histone modification;Histones;insight;Instruction;Knowledge;Lysine;Maintenance;male;Mammals;Methylation;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;Nature;next generation;novel;Nucleosomes;offspring;Organism;Phase;Process;programs;promoter;Promoter Regions;Proteins;Reading;recruit;Reporter;Research;Role;Specific qualifier value;Sperm Maturation;Spermatogenesis;Testing;Totipotency;Transcriptional Activation;Transgenic Mice;Work;Writing

PROJECT_TITLE: Determining cis- and trans- regulatory mechanisms of epigenetic bivalency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative This R50 application seeks fund to support Dr. Zhao Lai, Director of the Next-Generation Sequencing Shared Resource (NGSSR) of the NCI-designated Mays Cancer Center at the University of Texas Health San Antonio. The NGSSR, heavily used by Cancer Center members and investigators in the San Antonio area, has a strong focus on its unique Hispanic population, and provides cutting-edge high throughput sequencing expertise and analytical capacities to support diverse genomic applications. Dr. Lai, a highly skilled and well-trained genomics scientist, is a critical member who leads a cutting-edge scientific team in the NGSSR that supports and contributes intellectually to many NCI-funded projects through its expert genomic analyses.

PI_NAMEs: LAI, ZHAO  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Area;Award;Biological Assay;Cancer Center;Cancer Center Support Grant;cancer genome;cancer genomics;career development;Caring;Catchment Area;Collaborations;Communities;Core Facility;Development;Education;Environment;Experimental Designs;Funding;Genomics;Grant;Health;High-Throughput Nucleotide Sequencing;Hispanic Populations;improved;Infrastructure;innovation;instrumentation;Journals;Knowledge;Leadership;Letters;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Methodology;Mission;NCI Center for Cancer Research;next generation sequencing;Peer Review;Procedures;programs;Protocols documentation;Publications;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Research Project Summaries;Resource Sharing;Scientist;Secure;Services;skills;Specialist;Strategic Planning;success;Technology;Technology Assessment;technology validation;Texas;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Advancing Cancer Research Through Next Generation Sequencing at Mays Cancer Center of UT Health San Antonio


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_CITY: SAN FRANCISCO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The goal of this project is to investigate the cellular morphologies, behaviors, and signaling events that drive the asymmetric development of the murine incisor. The knowledge of these mechanisms at this unprecedented resolution will enable us to define the processes that drive the morphogenesis of teeth, and on a broader scale, various organs that use similar dynamic and tightly regulated epithelial-mesenchymal interactions. Furthermore, the knowledge of how tooth development is regulated will build a foundation to drive future regenerative dental therapies.

PI_NAMEs: HAQUE, AMEERA SAMAHER (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Affect;age effect;Apoptosis;Architecture;Atlases;Automobile Driving;Behavior;Biological Process;Bone Resorption;career;cell behavior;Cell Communication;Cell division;cell motility;Cell Proliferation;Cell Shape;Cell Size;Cells;Cellular Morphology;clinical training;comparison control;Computer software;Cues;cyclopamine;Dental;Dental Enamel;Dental Schools;Dentists;Dentition;Dentures;design;Development;Developmental Biology;digital;Disease;Distal;driving behavior;Embryo;Embryonic Development;Environment;Epithelium;Event;experimental study;Fellowship;Foundations;Future;Genetic;Goals;Growth;high resolution imaging;Image;Implant;improved;in vivo;Incisor;Individual;insight;Intercalated Cell;Investigation;Journals;Knowledge;Mandible;Maps;Measurement;Measures;Mechanics;Mediating;meetings;Mentorship;Mesenchymal;Mesenchyme;migration;Modeling;Molecular;Morphogenesis;morphogens;Morphology;Mus;mutant;Natural regeneration;Neck;novel;Nuclear;Organ;Organism;Organogenesis;Osseointegration;Pathway interactions;pharmacologic;Positioning Attribute;Process;programs;Proliferating;Qualifying;regenerative;regenerative approach;regenerative therapy;Research;Resolution;restorative dentistry;Role;Rotation;Scientist;Series;Shapes;SHH gene;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;small molecule inhibitor;software development;spatiotemporal;Specimen;Stratification;Structure;System;Techniques;Testing;tissue regeneration;Tissues;Tooth Germ;Tooth regeneration;Tooth structure;Training;Work

PROJECT_TITLE: Cellular Basis of Incisor Asymmetry

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Diabetes;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Bone healing is impaired in type 2 diabetes (T2DM). This project will study the role of diabetic macrophage derived-extracellular vesicles and their unique/novel miRNA act in concert with mesenchymal stem cells to control bone repair and regeneration. Successful completion of this work will refine knowledge of diabetic pathology and provide potential targets for therapeutic intervention as well as further innovative ways to control inflammation and regeneration that influences bone repair in T2DM.

PI_NAMEs: KANG, MIYA  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Affect;American;Applications Grants;Attention;Bioinformatics;Biological Assay;bone;bone fracture repair;bone healing;Bone Regeneration;bone repair;Calvaria;Cells;Chronic;Complex;Conditioned Culture Media;craniofacial bone;CRISPR/Cas technology;cytokine;Defect;Dentistry;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Engineering;Epidemic;Evaluation;experimental study;extracellular vesicles;Gene Expression Regulation;Genes;Immune response;Immune system;Immunologics;immunoregulation;Impaired wound healing;Impairment;Implant;In Vitro;in vitro Assay;indexing;Individual;Inflammation;innovation;knock-down;Knock-out;Knowledge;lentivirally transduced;Link;Macrophage;Measures;Mediating;Mesenchymal Differentiation;Mesenchymal Stem Cells;Messenger RNA;MicroRNAs;Modeling;morphometry;Natural regeneration;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Oral;Osseointegration;Osteogenesis;osteogenic;Outcome;paracrine;Paracrine Communication;Pathology;Pathway interactions;Phenotype;Physiological;Physiology;Play;Population;Procedures;Process;Publishing;repaired;Reporter Genes;Role;Scientist;Selection Criteria;Shapes;Signal Pathway;Signal Transduction;Standardization;Systemic disease;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Training;Undifferentiated;Wild Type Mouse;Work;wound

PROJECT_TITLE: Diabetes, Macrophages and Bone Regeneration

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR(01)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE This project will develop a cell-free DNA methylome approach to detect lung cancer and other cancers metastasized into the lung. The method will significantly facilitate the early detection of lung cancer in a non- invasive way.

PI_NAMEs: ZHOU, XIANGHONG JASMINE (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Age;Algorithms;Base Pairing;Benign;Biological Assay;Biological Markers;Biopsy;bisulfite sequencing;Blood;Bypass;Cancer Detection;cancer diagnosis;Cancer Patient;cancer type;cell free DNA;Chest;chest computed tomography;Clinical;Clinical Research;cohort;Cohort Studies;Collection;comorbidity;Complex;computational platform;computer framework;Copy Number Polymorphism;cost;cost effective;CpG Islands;Data;Death Rate;Diagnosis;Diagnostic;Diagnostic tests;Disease;DNA;DNA Methylation;DNA methylation profiling;Early identification;Epigenetic Process;Ethnic Origin;Etiology;former smoker;Gender;Genetic;genome wide methylation;genome-wide;Genomics;high risk;Human;Image;innovation;Learning;Lesion;Life;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Methods;Methylation;methylation biomarker;methylome;microbial;microbial composition;microbiome;Modeling;mortality;Names;Neoplasm Metastasis;Nodule;Organ;Pathogenesis;patient population;patient screening;Patients;Plasma;Primary Neoplasm;Procedures;psychologic;public health relevance;Race;Radiation;repository;Risk;Sample Size;Sampling;screening;Screening for cancer;Signal Transduction;Site;Source;Statistical Distributions;System;Systems Integration;Technology;Testing;Tissues;tool;Training;tumor;tumor DNA;Tumor-Derived;whole genome

PROJECT_TITLE: Detecting and locating cancer for patients with CT-detected lung nodules


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Temporomandibular Muscle/Joint Disorder (TMJD)

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal develops an acellular therapy for the in vivo regeneration of the mandibular condyle cartilage of the temporomandibular joint using a novel multi-layer scaffold design and biomaterials. The novel scaffold design will be used to recapitulate the native tissue architecture. Furthermore, we have developed a novel clinically relevant injury model for the TMJ in goats used in the proposed studies.

PI_NAMEs: TRBOJEVIC, SARA  (contact)

PROJECT_TERMS: Adult;Architecture;articular cartilage;Articulation;Bilateral;Binding;Biochemical;Biocompatible Materials;Biological Assay;Biological Availability;bioscaffold;BMP2 gene;bone;Bone Regeneration;Cartilage;cartilage degradation;cartilage regeneration;cartilaginous;Cells;Chondrocytes;clinically relevant;condylar cartilage;costal cartilage;Defect;design;Diffusion;ethylene glycol;fabrication;Fibroblasts;Fibrocartilages;Formulation;Functional Regeneration;Gelatin;Goat;Growth;Growth Factor;Heparin;Heparin Binding;Hyaline Cartilage;Hydrogels;Implant;In Vitro;in vivo;in vivo regeneration;Infiltration;Injury;Kinetics;Mandible;Mandibular Condyle;mechanical load;mechanical properties;migration;Miniature Swine;Modeling;Nanoporous;Natural regeneration;novel;osteochondral tissue;Osteogenesis;osteoprogenitor cell;Pain;Pathology;Patients;Periodicity;Permeability;Phenotype;Polymers;Porifera;prevent;Property;Publishing;regeneration potential;regenerative;Regenerative research;regenerative therapy;regenerative treatment;Replacement Arthroplasty;scaffold;Shapes;Site;stem cells;subchondral bone;Surface;Technology;Temporomandibular Joint;Temporomandibular Joint Disorders;Time;Tissue Engineering;tissue regeneration;Tissues;Training;Transforming Growth Factor beta;treatment effect

PROJECT_TITLE: Multilayer Scaffold for Condyle Surface Regeneration


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Disability Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative The proposed Johns Hopkins University-Hanoi University of Public Health Research Program on Health, Economic and Societal consequences of trauma and injuries in Vietnam (JHU-Hanoi HEalS) will build capacity for research on the consequences of injury, and post injury rehabilitation within health systems in Vietnam. We will develop a core group of researchers through a long-term training sequence for students in the Hanoi University of Public Health’s MPH, Master of Hospital Management degree program and program on rehabilitation to ensure sustainable research capacity development in the region. We will create a center of excellence for research on the consequences of injury and post injury rehabilitation at HUPH, where we will also offer non-degree short-term trainings such as workshops, online courses, and webinars on key priority topics.

PI_NAMEs: BACHANI, ABDULGAFOOR M. (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Area;Collaborations;Data;disability;economic impact;Economics;experience;Goals;Government;healing;Health;Incidence;Individual;Injury;Institution;International;Intervention;Leadership;low and middle-income countries;Modeling;mortality;Persons;Policies;programs;Public Health;public health research;Public Health Schools;Recording of previous events;Rehabilitation therapy;Research;response;Science;Social Impacts;Southeastern Asia;Training Programs;Trauma;Universities;Vietnam;Vietnamese;Work;World Health Organization;years lived with disability


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: The etiology of the megakaryocyte defect in thrombocytopenia absent radius (TAR) syndrome is still not understood, and the postnatal emergence of the thrombocytopenia suggests that definitive hematopoiesis may be more insightful than primitive hematopoiesis to model its pathogenesis. Though functional and qualitative differences between megakaryocytes derived from primitive and definitive hematopoiesis has been well described, the mechanisms responsible for these differences or if they can lead to inequal disease phenotype penetrance has not been determined. The proposed study will expand our understanding of the pathogenesis of TAR syndrome, megakaryocyte biology at different stages of development, and how mutations affecting ubiquitous cellular processes may exhibit lineage-specificity in order to improve the relevancy of in vitro disease models and tailor therapeutic strategies to distinct tissue systems.

PI_NAMEs: NATIONS, CATRIANA  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Ablation;Affect;Agonist;Alleles;Apoptosis;Apoptotic;Axon;Biological Assay;Biology;Blood;Blood Cells;Blood Platelets;Blood specimen;Cell Cycle;Cell Cycle Arrest;Cell Cycle Progression;Cell Cycle Regulation;Cell Death;Cell Line;Cell Lineage;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;Characteristics;Complex;Congenital Disorders;Defect;Development;disease model;disease phenotype;Embryo;Erythroid;Etiology;Exhibits;experimental study;Feedback;Flow Cytometry;gene correction;Generations;Genes;Genetic;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;human disease;Impairment;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;insight;Knockout Mice;Life;Megakaryocytes;Megakaryocytopoieses;Messenger RNA;Mitotic;Modeling;mouse model;mRNA Expression;Mutation;Myelogenous;novel;Organism;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Penetrance;Phenotype;Platelet Count measurement;Ploidies;Polyploid Cells;Population;postnatal;Predisposition;premature;Process;progenitor;programs;Proliferating;promoter;Proteins;Radial;Regulation;response;RNA;RNA Processing;RNA Splicing;Role;Sampling;Single Nucleotide Polymorphism;skeletal;small hairpin RNA;Specificity;stem cell model;stem cells;Surface;Syndrome;System;Testing;Therapeutic;Thrombocytopenia;Tissue-Specific Gene Expression;Tissues;TP53 gene;transcriptome sequencing;Umbilical Cord Blood;Untranslated RNA;Validation;Yolk Sac

PROJECT_TITLE: Investigating thrombocytopenia absent radius syndrome during primitive and definitive hematopoiesis using an induced pluripotent stem cell model


NIH_SPENDING_CATS: Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative Preterm birth is the leading cause of neonatal morbidity and mortality, is frequently associated with maternal morbidity, and is significantly more common among Black women. The interactions of race with mechanisms that cause preterm birth and on potential preterm birth biomarkers are not fully understood. I will conduct a paired analysis of vaginal metabolites and metagenomics in a racially diverse cohort of pregnant women to quantify the interactions among race, vaginal metabolites, vaginal microbes, and preterm birth, in order to address a significant reproductive health challenge and driver of racial inequity.

PI_NAMEs: KINDSCHUH, WILLIAM FRANCIS (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 16S ribosomal RNA sequencing;37 weeks gestation;Address;Affect;Biological Markers;biomarker identification;Birth;black women;Clinical;Clinical Data;cohort;Computational Biology;Data;Data Analyses;data modeling;Early Diagnosis;Elements;Environmental Risk Factor;explainable machine learning;Foundations;Future;genetic element;Genomics;Growth;high risk;improved;innovation;insight;Intervention;Investigation;Lifelong disability;machine learning model;Maternal complication;maternal morbidity;mathematical model;Measures;Medical;Metabolic;Metabolism;metabolome;metabolomics;Metadata;metagenomic sequencing;Metagenomics;Microbe;microbial;microbial products;microbiome;microbiome composition;microorganism interaction;mortality;Mothers;neonatal morbidity;Neonatal Mortality;neonate;novel;Nulliparity;Participant;Population;Population Heterogeneity;potential biomarker;Pregnancy;Pregnancy Rate;Pregnant Women;Premature Birth;prevent;Prevention;Race;racial disparity;racial diversity;Reproductive Biology;Reproductive Health;Research;Resolution;Risk Factors;Role;Sample Size;Sampling;Second Pregnancy Trimester;social;social factors;socioeconomics;Statistical Methods;Swab;Time;Tyramine;United States;Vagina;vaginal microbiome;Virulence;White Women;Work

PROJECT_TITLE: Quantifying the interactions among maternal race, vaginal metabolites, and microbes in preterm birth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: Natick

ORG_NAME: AUTOIVF, INC.

ORG_STATE: MA

PHR: Project Narrative While the demand for fertility treatments is on the rise because of the increasing age that women seek to become pregnant, the high cost and accessibility of IVF is the leading reason why couples choose not to undergo and/or delay the treatment. The ability to automate various functions of an embryology lab will enable decentralization of IVF and pave the way to reduced treatment costs and improved accessibility. We will develop and commercialize a novel microfluidic system, OvaSafe, for standardized and automated vitrification of oocytes, in order to support an approach of providing IVF services in remote and small clinics.

PI_NAMEs: OZKUMUR, ISMAIL EMRE (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: access restrictions;Age;Area;Automation;blastocyst;Blood capillaries;Cells;Clinic;Clinical;Collection;commercialization;Competence;Complement;Complex;Computer software;cost;Couples;Coupling;Cryopreservation;Decentralization;design;Developed Countries;Development;Device Designs;Devices;egg;Embryo;Embryology;Equipment;Evaluation;Exposure to;fertility preservation;Fertilization;Fertilization in Vitro;Follicular Fluid;Future;geographic inaccessibility;Germ Cells;Goals;Growth;Hand;Human;Human Resources;improved;Incubated;infertility treatment;innovation;Label;Laboratories;Liquid substance;Manuals;manufacture;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;Mission;Morphology;mouse model;Mus;new technology;Nitrogen;novel;Oocytes;Osmosis;Outcome;Phase;phase 1 designs;Population Density;pregnant;preservation;Procedures;Process;Protocols documentation;response;Sampling;Services;Signal Transduction;Silicon Dioxide;Small Business Innovation Research Grant;Standardization;Stress;success;System;Technology;Toxic effect;Training;Treatment Cost;United States;usability;Validation;Variant;Woman;Work

PROJECT_TITLE: OvaSafe: A microfluidic device enabling automated oocyte vitrification


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Telehealth

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative The objectives of this project are to develop and determine the effectiveness of an mHealth smartphone technology which can be used to engage primary caregivers directly in the active monitoring of their infants’ development, and to provide tailored feedback and support for the provision of nurturing care and positive infant developmental outcomes. In addition, we will also prospectively assess the implementation characteristics of the technology—usability, acceptability, and sustainability—for caregivers and health workers in a rural Guatemalan population which is at high risk for impaired infant growth and development. Following successful implementation in Guatemala, this mHealth method could then be expanded to families with at-risk infants worldwide.

PI_NAMEs: ROHLOFF, PETER ;SMITH, BETH A (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Age Months;Area;Behavior;Biomedical Engineering;Birth;caregiver functioning;Caregiver support;Caregivers;caregiving;Caring;Cellular Phone;Characteristics;Child;Child Psychology;Child Rearing;Client;Clinical;Clinical effectiveness;Community Psychology;Counseling;Data;design;Development;developmental psychology;Discipline of Nursing;Effectiveness;effectiveness evaluation;Elements;empowerment;Enrollment;Environment;evidence base;Family;Feedback;feeding;Focus Groups;Foundations;Growth and Development function;Guatemala;Guatemalan;Health;Health Alliance;Health Personnel;Healthcare Systems;high risk;Home;Human Resources;Impairment;implementation evaluation;improved;Infant;Infant Care;Infant Development;Infant Health;innovation;Institution;interactive feedback;Intervention;Intervention Studies;Interview;Los Angeles;low and middle-income countries;Measurement;Measures;Methods;mHealth;mhealth interventions;mobile computing;Monitor;multidisciplinary;Outcome;Outcome Measure;Pediatric Hospitals;Perception;Phase;Physical therapy;Population;Poverty;preference;primary caregiver;primary outcome;Printing;Process;prospective;public health priorities;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;research and development;Research Personnel;Resources;Risk;Rural;Sample Size;secondary outcome;Services;smartphone application;Structure;Target Populations;Taxes;Technology;Telephone;Testing;Time;tool;Training;Universities;usability;Validation;Work

PROJECT_TITLE: Mobile Health Intervention to Promote Positive Infant Health Outcomes in Guatemala


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Oral clefts are among the most common birth defects, affecting 1 in 700 live births. Although problems with language and literacy have been well-documented in children with clefts, there are currently no studies of interventions to address these problems. This randomized controlled trial study will be the first to test the efficacy of a shared reading intervention, developed to meet the needs of children with oral clefts and their caregivers, in improving language and literacy outcomes.

PI_NAMEs: COLLETT, BRENT RUSSELL (contact)

PROGRAM_OFFICER_NAME: MATTIA, JILL

PROJECT_TERMS: Abbreviations;Address;Affect;Age;Appointment;Attention;Awareness;Behavior;Behavioral;Benchmarking;Books;Caregivers;Caring;Catchment Area;Cellular Phone;Characteristics;Child;Child Care;Child Language;Child Rearing;Clinic;Clinic Visits;Clinical;Congenital Abnormality;Consent;Control Groups;craniofacial;Development;Disparity;Educational Status;effective intervention;efficacy testing;Enrollment;Ensure;Family;Frequencies;Geography;group intervention;Health;Heterogeneity;high risk;Home;improved;Infant;innovation;Intervention;intervention delivery;Intervention Studies;Intervention Trial;Language;Latino;Linguistics;literacy;Live Birth;Los Angeles;Manuals;Measures;Mediating;Mediation;Monitor;novel;operation;oral cleft;Outcome;palate repair;Parent-Child Relations;Parenting Education;Parents;Participant;participant enrollment;Pathologist;patient population;Patients;Pediatric Hospitals;peer;Persons;Phase;pilot test;Population;Prevalence;Printing;programs;Protocols documentation;Provider;Randomized;Randomized, Controlled Trials;Reading;recruit;remote delivery;remote intervention;Remote session;Research;Risk;Rural;rural area;Sampling;Secure;skills;smartphone application;social;Spanish;Spanish/English;Speech;Target Populations;telecoaching;Testing;Text Messaging;Training;Training Activity;Translating;Translations;Treatment Efficacy;Video Recording;Videoconferencing;Visit;Vulnerable Populations

PROJECT_TITLE: Shared Reading Intervention for Children with Oral Clefts


ADMINISTERING_IC: OD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Dental, Oral, and Craniofacial Disease;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: PROJECT NARRATIVE Approximately 8.5 million Americans participate annually in competitive high school or collegiate sport, greatly elevating their risk for musculoskeletal injury and perhaps positioning them for poor long-term health and function. The proposed DP5 research will evaluate the impact of prior knee injury and sedentary behavior as two potential mechanisms of later poor health and reduced function. The findings will inform the way we rehabilitate, counsel, and educate athletes for long-term health and lead to future longitudinal and intervention studies that will ultimately decrease chronic disease in mid-life, enhancing healthspans.

PI_NAMEs: CAPIN, JACOB J (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adult;Age;aging population;American;Athletic;Behavior Therapy;Body Composition;Body fat;cardiometabolism;cardiovascular disorder risk;career;career development;Certification;Chronic Disease;chronic pain;Clinical;cohort;college;cost;Counseling;Data;Degenerative polyarthritis;Delaware;design;Development;disability;Disease;Doctor of Philosophy;doctoral student;early onset;Equipment;Exercise;experience;Faculty;Female;Funding;Future;General Population;Goals;Guidelines;hamstring;Health;Health Promotion;health related quality of life;healthspan;high school;HRK gene;improved;Injury;innovation;Institution;Intervention;Intervention Studies;Knee Injuries;Laboratories;Life;life span;longitudinal analysis;Longitudinal Studies;male;Manuscripts;Medical;Mentors;Methods;middle age;Minority;moderate-to-vigorous physical activity;mortality;Musculoskeletal;musculoskeletal injury;National Institute of Child Health and Human Development;Nonpharmacologic Therapy;novel;Outcome;Participant;Pattern;peer;Peer Review;Persons;Physical activity;physical therapist;Physical therapy;Play;Population;Populations at Risk;Positioning Attribute;Postdoctoral Fellow;prevent;Procedures;professor;programs;Publications;quadriceps muscle;Quality of life;Recommendation;Recording of previous events;Rehabilitation therapy;Research;Research Assistant;Research Support;Research Training;Resources;Risk;Risk Factors;Scientist;sedentary;sedentary lifestyle;Services;Sports;success;Testing;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Walking;Work

PROJECT_TITLE: Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The stiffness of the mammalian ovary increases significantly with age, yet the spatial and temporal  dynamics of this tissue stiffness, how it impacts follicular development, and how mechanical signals from  the ovary are transmitted to the follicle have not been explored. In this R00 application I examine how the  increase in the biomechanical properties of the ovary with age are spatially and hormonally regulated and  how they influence follicle transcriptome through the YAP1 pathway. Overall, the proposed studies will

PI_NAMEs: AMARGANT I RIERA, FARNERS  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;advanced maternal age;Affect;Age;age related;age related changes;Aging;Alginates;Aneuploidy;Architecture;Award;Behavior;Biochemical;Biomechanics;cell behavior;Cell Death;Cells;Characteristics;Competence;corpus luteum;Cues;Deterioration;Development;Diestrus;Encapsulated;Environment;Estradiol;Estrogens;Estrous Cycle;Estrus;Female;female fertility;female reproductive system;Fertility;folliculogenesis;Foundations;Gel;Gene Expression Profile;Gene Modified;Grant;granulosa cell;Growth;Hormonal;Human;Hydrogels;In Vitro;Infertility;insight;Kinetics;Link;Maps;Measures;mechanical properties;mechanical signal;mechanotransduction;medical schools;Metestrus;Methods;Mission;Molecular;mouse model;Mus;National Institute of Child Health and Human Development;novel;old mice;oocyte quality;Oocytes;Organ;Ovarian;Ovarian aging;Ovarian hormone;Ovary;Pathologic;Pathway interactions;Phase;Physical environment;Physiological;Polycystic Ovary Syndrome;Positioning Attribute;Postdoctoral Fellow;Primordial Follicle;Process;Proestrus;professor;Progesterone;Property;reproductive;reproductive senescence;Research;Resolution;Signal Transduction;spatiotemporal;Structure;System;Testing;three dimensional structure;Tissues;Transcription Factor AP-1;transcriptome;transmission process;United States National Institutes of Health;Universities;Washington;Woman;Work

PROJECT_TITLE: Mechanotransduction mechanisms of ovarian aging

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

PHR: Spinal cord injury (SCI) is a major medical illness, as it affects many Veterans, and it affects their quality of life. Several important organ functions are affected such as bladder, bowel, and sexual function due to the limited intrinsic healing capacity of the spinal cord and the absence of effective therapeutic interventions. The major focus of this proposal is to evaluate the feasibility of the application of a novel combination therapy to improve urinary bladder functional recovery after SCI in an animal model. We believe the proposed studies will have important therapeutic implications for future treatment strategies for SCI-related autonomic organ function recovery.

PI_NAMEs: RAJASEKARAN, MAHADEVAN RAJ (contact)

PROJECT_TERMS: Affect;Animal Model;Area;Axon;axon regeneration;Bladder;Bladder Control;Bladder Dysfunction;Brain;Cell Nucleus;Central Nervous System;clinical translation;clinically relevant;combinatorial;Combined Modality Therapy;Communication;Complex;Contusions;Corticospinal Tracts;Data;Demyelinations;detrusor muscle;Devices;disability;Environment;experience;Feasibility Studies;feasibility testing;Functional disorder;Future;Genitourinary system;Goals;Growth;healing;Human;improved;Incontinence;Inflammation;Injury;innovation;Interruption;Intervention;Intervention Studies;Intestines;Ischemia;Laboratories;Lesion;Life;Locomotion;Magnetism;Medical;Modeling;Monitor;Motor;motor impairment;muscle hypertrophy;Natural regeneration;nerve injury;nerve stem cell;neural circuit;neural facilitation;neural graft;Neurogenic Bladder;neuronal survival;Neurons;neuroprotection;neuroregulation;novel;Organ;Paraplegia;Pathway interactions;Patients;Pontine structure;Quality of life;Rattus;Recovery;Recovery of Function;Recurrence;Reflex action;Regenerative Medicine;Rehabilitation therapy;Reporting;Research;Research Personnel;Rodent;Sensory;Severities;Sex Functioning;Signal Transduction;Sphincter;Spinal;Spinal Cord;Spinal cord injury;Spinal cord injury patients;Spinal Injuries;stem cell differentiation;successful intervention;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tissue repair;Training;translational potential;treatment strategy;Urinary tract;Urinary tract infection;Urination;Urology;Veterans;Work

PROJECT_TITLE: Feasibility Testing of a Novel Combination Therapy To Improve Genitourinary Function Recovery After Spinal Cord Injury in a Rat Model

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: LIMA

ORG_COUNTRY: PERU

ORG_FIPS: PE

ORG_NAME: UNIVERSIDAD PERUANA CAYETANO HEREDIA

PHR: Oxfendazole in Neurocysticercosis Principal Investigator/Program Director: GARCIA, Hector H. A multicenter, randomized controlled trial of single and three-dose  regimens of oxfendazole for mild (one or two lesions)  parenchymal brain cysticercosis NARRATIVE  The cystic larvae of the pork tapeworm Taenia solium can infect the human brain and cause epilepsy. This condition, named neurocysticercosis (NCC), still accounts for approximately one third of epilepsy cases in most of the world. Anti-parasitic drugs destroy the cysts and also result in clinical benefits. Still, the efficacy of the best available regimens offer less than 70% efficacy in parenchymal brain NCC with one to two lesions, which is the most form of presentation in the Indian subcontinent, in pediatric populations worldwide, in travelers to endemic regions, and in non-endemic regions such as the US. The recent development of oxfendazole (OXF) as a potential anti-parasitic agent for human use may provide increased efficacy and easier administration. We will perform a controlled trial in Peru and India comparing a single dose and a three-dose regimes of OXF with the currently used 10 day regime of ABZ plus PZQ.

PI_NAMEs: GARCIA, HECTOR HUGO (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Aftercare;Albendazole;Antiparasitic Agents;arm;Brain;calcification;Central Nervous System;Childhood;Cicatrix;Clinical;Clinical effectiveness;Cognitive deficits;cohort;Cohort Studies;Combined Modality Therapy;comparative efficacy;Cyst;Data;Developed Countries;Development;Diagnosis;diagnostic assay;Disease;DNA;Dose;Double-Blind Method;Early identification;efficacy evaluation;Epilepsy;Evaluation;Future;Geographic Locations;Gliosis;Goals;hippocampal atrophy;Human;Image;imaging biomarker;Immigrant;improved;India;Individual;Infection;Larva;Lesion;Leukocytes;long-term sequelae;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Morbidity - disease rate;Names;Neurocysticercosis;Neurologic;Oral;Parasites;Peru;Population;Praziquantel;Principal Investigator;Prognosis;programs;Publications;Quality of life;Radiology Specialty;Randomized, Controlled Trials;Regimen;Relapse;Residual state;Resolution;response;Safety;safety assessment;Sampling;Seizures;Serum;Taenia solium;Testing;tool;treatment choice;Urine;Ventricular

PROJECT_TITLE: A multicenter, randomized controlled trial of single and multiple dose regimes of oxfendazole for mild (one or two lesions) parenchymal brain cysticercosis


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative In 10% of elderly patients, pancreatic ductal adenocarcinoma (PDAC) originates from mucin-producing cystic precancerous lesions called intraductal papillary mucinous neoplasms (IPMNs). Activating mutations in GNAS(R201C) are thought to drive IPMN-derived PDAC, but the cell of origin for IPMN initiation is not known. This proposal aims to take advantage of human stem cell-derived pancreatic ductal and acini organoids to understand how oncogenic GNAS supports initiation and progression of IPMNs in pancreatic cancer.

PI_NAMEs: DESAI, RIDHDHI R (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Abdomen;Acinus organ component;Address;Advisory Committees;Age;anti-cancer research;Area;Binding;Biology;Biotinylation;Cancer Biology;Cancer Model;Carcinoma;career;career development;Cell Proliferation;cell type;Cells;Cellular biology;combinatorial;Cyclic AMP-Dependent Protein Kinases;Cyst;Cystic Neoplasm;Data;Development;Diagnosis;Disease;DNA Sequence Alteration;Doxycycline;Duct (organ) structure;Ductal Epithelial Cell;Ductal Epithelium;Educational workshop;Environment;Epithelium;Event;Exocrine pancreas;experience;Faculty;Frequencies;Funding;Funding Opportunities;Future;Genes;Genetic;Genetic Screening;Genetically Engineered Mouse;Genomics;Grant;GTP-Binding Proteins;Human;human embryonic stem cell;human stem cell-derived;Image;in vivo;Individual;Induced Mutation;inhibitor;insight;Institution;islet stem cells;K22 Award;Knowledge;KRAS2 gene;KRASG12D;Laboratories;Lesion;Libraries;loss of function;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mentorship;Modeling;Mucin-2 Staining Method;Mucinous Neoplasm;Mucins;Mus;Mutation;older patient;Oncogenes;Oncogenic;Organoids;Other Genetics;Pancreas;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic Intraepithelial Neoplasia;Papillary;Pathogenesis;Patients;Phase;Phenotype;Physiological;PIK3CA gene;Positioning Attribute;premalignant;Proteomics;Research;Research Personnel;Research Proposals;Resources;Secure;Signal Transduction;small hairpin RNA;Supervision;Surface;Survival Rate;System;Testing;Therapeutic;Tissues;Training;Transplantation;tumor;Writing

PROJECT_TITLE: Understanding initiation and progression of IPMNs in pancreatic cancer


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Neurosciences

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: 8. Project Narrative    . Cardiac arrest is a common and devastating cardiac and neurological emergency affecting almost 400,000 victims in the US every year, many of whom are successfully resuscitated but then die in the hospital or are left with severe disability from injury to the brain during the cardiac arrest. Immediate temperature control and cooling of comatose survivors of cardiac arrest is now commonly used to try to reduce the brain injury, but it remains uncertain whether it is truly effective, how long a survivor of cardiac arrest should be cooled, and which patients are more likely to benefit. This clinical trial proposes to first determine whether longer durations of cooling improve recovery better than shorter durations, and secondly to determine the best duration of cooling, in comatose patients resuscitated from either of two different types of cardiac arrest.

PI_NAMEs: RAMAKRISHNAN, VISWANATHAN ;YEATTS, SHARON DZIUBA (contact)

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: Accident and Emergency department;Address;Affect;Applications Grants;Assessment tool;Brain;Brain Injuries;Cardiac;Cardiopulmonary Resuscitation;Case Report Form;Categories;Cerebral Ischemia;Cessation of life;Clinical;clinical investigation;clinical practice;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collection;Coma;Common Data Element;Companions;Data;Data Coordinating Center;data management;data quality;Data Set;Databases;design;Development;Devices;disability;Dose;electronic data;Eligibility Determination;Emergency Situation;Enrollment;Evaluation;experience;Goals;Guidelines;Health Sciences;Heart;Heart Arrest;Hospitals;implementation facilitation;improved;improved outcome;Infrastructure;Injury;innovation;Left;Link;Manuscripts;Medical;method development;Methods;Michigan;Monitor;Multi-site clinical study;Multicenter Trials;National Heart, Lung, and Blood Institute;natural hypothermia;Neurologic;Neurological emergencies;Neurological outcome;neurological recovery;novel;Online Systems;organizational structure;out-of-hospital cardiac arrest;Outcome;Outcome Assessment;patient population;Patient Selection;Patients;Performance;Periodicals;pre-clinical;Procedures;Protocols documentation;Public Health;Qualifying;Randomized;Recommendation;Recovery;Reporting;Research Design;Resources;response;Risk;Role;Safety;Selection Criteria;South Carolina;Specific qualifier value;Survivors;System;Talents;Temperature;Therapeutic;treatment effect;trial design;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: 2/2 ICECAP: Influence of Cooling duration on Efficacy in Cardiac Arrest Patients

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Depression;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Advancements in computational psychiatry allow us to isolate the contributions of multiple, specific, cognitive mechanisms that contribute to the behavior that we see in everyday life. This approach fills a critical unmet need in psychiatry by generating mathematically precise variables that can bridge the gap between pathophysiology and psychopathology. The main goals of the current project are to: 1) test the idea that computational metrics have enhanced validity and sensitivity relative to standard behavioral performance metrics in key psychiatric and nonpsychiatric populations and to relate these metrics to EEG markers of brain function; and 2) establish and optimize the psychometrics of these computational metrics so that they can be used as tools in treatment development, longitudinal studies, and genetic studies.

PI_NAMEs: MACDONALD, ANGUS W (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Affective;Anhedonia;Assessment tool;Attention;Behavior;behavior measurement;Behavioral;Big Data;Brain;Clinic;Clinical;clinical application;clinical predictors;Cognition;Cognitive;cognitive function;cognitive neuroscience;cognitive process;cognitive system;cognitive testing;Communities;computerized tools;Data;Data Collection;Decision Making;Dimensions;discounting;Electroencephalography;Episodic memory;Evaluation Studies;flexibility;Floor;Functional disorder;functional outcomes;Genetic;Genetic study;Goals;Gold;Human;Impaired cognition;Impairment;Individual;interest;Internet;Intervention;Laboratories;Learning;Life;Longitudinal Studies;Mathematics;Measurement;Measures;Mental Depression;Mental disorders;Methods;Modeling;Mood Disorders;Motivation;neural;neuromechanism;neurophysiology;novel;Parameter Estimation;Patient Recruitments;Patients;Pattern;Perception;Performance;Population;population based;Positive Valence;precision medicine;Productivity;Property;Psychiatry;psychologic;Psychological reinforcement;Psychometrics;Psychopathology;Psychotic Disorders;psychotic-like experiences;recruit;Research;Research Domain Criteria;Research Personnel;Resources;Sampling;severe mental illness;Short-Term Memory;Site;spatiotemporal;Specific qualifier value;Specificity;Symptoms;System;Task Performances;Testing;therapy development;tool;tool development;Translating;Variant;Visual Perception;web-based tool;Work

PROJECT_TITLE: 5/5-Cognitive Neurocomputational Task Reliability & Clinical Applications Consortium


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative DNA replication, the duplication of the cell’s genetic material, requires over 3 dozen proteins to orchestrate this complex process and any of these processes gone awry can lead to human disease, including metastatic cancer. The studies proposed here are basic studies using pure proteins to understand very specifically on how these many proteins function together to duplicate DNA, but with an eye toward processes that may lead to human abnormal function, especially for epigenetic inheritance that is known to cause human disease. However, there are certainly other disease related processes that will come to light as the basic mechanism of how the replication machinery functions.

PI_NAMEs: O'DONNELL, MICHAEL E (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: ATR gene;Binding;Biochemical;Biochemistry;Cells;Closure by clamp;Collaborations;Complex;dimer;Disease;Disseminated Malignant Neoplasm;DNA;DNA biosynthesis;DNA damage checkpoint;DNA Primase;DNA Repair;DNA replication fork;DNA-Directed DNA Polymerase;Enzymes;Epigenetic Process;Genetic Materials;helicase;Histones;Human;human disease;Hybrids;insight;Investigation;Left;Malignant Neoplasms;Methods;Mismatch Repair;mutant;Nuclear;Nucleosomes;Pathway interactions;Polymerase;prevent;Process;protein function;protein purification;Proteins;Reaction;reconstitution;RNA;Saccharomyces cerevisiae;scaffold;Signal Transduction;single molecule;Site;Slide;Structure;superresolution microscopy;System;time use;Twin Multiple Birth;Universities;Visualization;Yeasts

PROJECT_TITLE: Biochemistry of Eukaryotic Replication Fork and DNA Repair

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: African Genomics Data Hub Biomedical Knowledgebase Project Narrative Africa is the continent with the highest human genetic diversity, yet the data documenting this diversity and its impact on health are scarce and often unavailable. We aim to increase both the accuracy and the availability of African genomic data, tools and resources to ensure that maximal benefit can be derived not only for people of African ancestry, but also globally.

PI_NAMEs: GHEDIRA, KAIS ;JAUFEERALY-FAKIM, YASMINA ;MULDER, NICOLA  (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Adherence;Africa;African;African ancestry;Area;Attention;Automobile Driving;Basic Science;Case Report Form;Catalogs;Clinical;ClinVar;Collection;Communities;Complement;Consent;Data;Data Collection;data hub;data portal;data quality;Data Reporting;Data Set;data standards;data submission;database of Genotypes and Phenotypes;Databases;dbSNP;Development;Ensure;experience;FAIR principles;Future;Genbank;Gene Frequency;Genetic;Genetic Variation;Genome;genome resource;genome wide association study;genomic data;Genomic medicine;genomic variation;Genomics;Genotype;Geography;Goals;Graph;Health;Human Genetics;improved;indexing;International;knowledgebase;Linguistics;Literature;Metadata;Multiomic Data;multiple omics;Ontology;Output;pan-genome;Pathogenicity;Persons;Phenotype;phenotypic data;Population;Production;Proteomics;public database;public repository;rapid growth;repository;Research;Research Personnel;Resources;Scientist;Services;Specific qualifier value;Standardization;Statutes and Laws;tool;Training;transcriptomics;Translations;Trust;United Kingdom;Variant;web portal;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)S]


ORG_NAME: BALTIMORE VA MEDICAL CENTER

PHR: The current Coronavirus Disease 2019 (COVID-19) pandemic is threatening the health of Americans - including our Veterans. Currently, there are no proven methods for treatment or prevention of COVID-19. The ultimate goal of this project is to understand the antibody responses to the outer part of the virus that causes COVID-19 and to isolate monoclonal antibodies against it. With this information, we are hoping we can come up with new therapeutics for treatment and prevention of COVID-19 in our Veterans.

PI_NAMEs: SAJADI, MOHAMMAD MOHSENI (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Affinity Chromatography;American;Animals;Antibodies;Antibody Response;Antigens;Award;B-Lymphocytes;Binding;Binding Sites;Biochemical;Biological Assay;biosafety level 3 facility;Categories;Cells;Cessation of life;Characteristics;Charge;Codon Nucleotides;convalescent plasma;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 prevention;Disease;Doctor of Philosophy;Electrophoresis;Enrollment;env Gene Products;Epitope Mapping;Epitopes;experience;experimental study;Family;Fractionation;Goals;Hand;Health;Healthcare Systems;HIV;Human;Immunity;Immunoglobulin A;Immunoglobulin G;Individual;Infection;Inpatients;interest;Isoelectric Point;Knowledge;Libraries;Maps;Maryland;Mass Spectrum Analysis;Medical;Membrane Glycoproteins;Memory B-Lymphocyte;Methods;Monoclonal Antibodies;multiple myeloma M Protein;neutralizing antibody;novel therapeutics;novel vaccines;Nucleoproteins;Outpatients;pandemic disease;participant enrollment;Patients;Persons;Phase;Plasma;Plasmablast;Plasmids;polyclonal antibody;Prevention strategy;Production;programs;Proteins;Protocols documentation;receptor binding;Research;response;Running;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 spike protein;System;Techniques;Testing;treatment strategy;United States;Universities;Vaccines;Veterans;Viral;Virus;X-Ray Crystallography

PROJECT_TITLE: COVID-19:  Elucidating monoclonal and polyclonal seroantibody responses to the COVID-19 viral envelope


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Support is requested for a multidisciplinary predoctoral Dartmouth Training program in Quantitative Cancer Research. It is our vision that the next generation of quantitative researchers will require skills and expertise from areas such as bioinformatics, biostatistics, and epidemiology to tackle the most challenging problems in future cancer research.

PI_NAMEs: GERBER, SCOTT A. (contact);GILBERT-DIAMOND, DIANE IHN AE;TOSTESON, TOR D

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: anti-cancer research;Training Programs

PROJECT_TITLE: Dartmouth Training Program in Quantitative Cancer Research

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: The proper organization of DNA replication and balanced cell growth and division are essential for cellular homeostasis and viability. The proposed research will investigate how cells organize their growth and replication, allowing for the investigation of the role of disruption of these mechanisms in the etiology of human cancer and aging.

PI_NAMEs: RHIND, NICHOLAS R (contact)

PROJECT_TERMS: Aging;Blood Platelets;cancer cell;Cell Cycle;Cell division;cell growth;Cell Physiology;Cell Size;Cells;Cellular biology;Characteristics;chromatin modification;Chromosome Structures;Degenerative Disorder;Development;DNA biosynthesis;DNA replication origin;DNA Replication Timing;Etiology;event cycle;Evolution;experimental study;Fission Yeast;Gene Expression;Genome;Genome Stability;Genomic Instability;Growth;Heterogeneity;Homeostasis;Human;Individual;interest;Investigation;Learning;Location;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Metabolism;Mitosis;Mitotic;Nuclear;Oocytes;Organizational Decision Making;overpopulation;Pathologic;Pathway interactions;Pattern;Phenotype;prevent;Probability;Proteins;Regulation;Regulation of Cell Size;Replication Origin;Research;Role;Saccharomycetales;single molecule;System;Techniques;Testing;Tissues

PROJECT_TITLE: Regulation of Key Cell Cycle Events

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Data Science;Estrogen;Genetics;Human Genome;Lung;Lung Cancer;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: NUTRITION

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative We propose to continue the follow-up of the Nurses' Health Study II (NHSII), a Cancer Epidemiology Cohort of 116,430 women enrolled in 1989 at ages 25 to 42 years. Data include repeated measures of diet, physical activity, and other exposures over 33 years of follow-up, as well as blood, urine, buccal cells, stool and tumor tissue biospecimens. Cohort follow-up is reaching the most informative phase and is a unique resource for scientific aims that integrate exposures over the life course, including diet, other lifestyle variables, biomarkers, genetic predisposition and mediating variables, in relation to cancer risk and survival.

PI_NAMEs: ELIASSEN, A. HEATHER ;WILLETT, WALTER C. (contact)

PROGRAM_OFFICER_NAME: MAHABIR, SOMDAT

PROJECT_TERMS: Age;analytical tool;Archives;attenuation;Benign;Big Data;biobank;Biological Markers;Blood;Breast;breast cancer diagnosis;cancer epidemiology;cancer risk;cancer survival;Cancer Survivor;case control;Cells;Cessation of life;Cheek structure;Cloud Computing;cohort;Cohort Analysis;Collaborations;Collection;Colon;Colorectal;Complex;Computers;Consultations;Data;Data Analytics;Data Collection;data complexity;data management;data sharing;Diagnosis;Diagnostic;diagnostic screening;Diet;Disease Progression;DNA;Endometrial Carcinoma;Enrollment;Erythrocytes;Ethanol;fecal microbiome;Feces;follow-up;Funding;Gene Expression;Gene Expression Microarray Analysis;genetic analysis;Genetic Predisposition to Disease;genome wide association study;Germ Lines;gut microbiome;high school;Immunohistochemistry;improved;in utero;Incidence;indexing;Individual;Infant;Information Systems;Infrastructure;investigator training;Language;Lesion;Leukocytes;Life Cycle Stages;Life Style;lifestyle factors;Lymphoma;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammography;Measures;Mediating;Medical;Melanoma;member;Menopause;metabolomics;Methods;microbiome analysis;Modernization;mortality;Mothers;Normal tissue morphology;Nurses' Health Study;Oral;oral microbiome;Ovarian;Paper;Participant;Perinatal Exposure;Persons;Pharmaceutical Preparations;Phase;Physical activity;Plasma;Postmenopause;Premenopause;Productivity;Publications;Publishing;Quality of life;relational database;Reproducibility;Research Personnel;Resource Sharing;Resources;Sampling;Secure;Smoking;Specimen;Tissue Microarray;tissue resource;Tissues;Tube;tumor;Tumor Tissue;United States National Institutes of Health;Update;Urine;usability;Weight;Whole-Genome Shotgun Sequencing;Woman;Women's cohort;women's diagnosis

PROJECT_TITLE: Life Course Cancer Epidemiology Cohort in Women


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

PHR: Project Narrative Despite effective treatments for choroidal neovascularization, age-related macular degeneration (AMD) remains the leading cause of blindness in the US due to the eventual development of atrophy in the long-term. As current attempts to develop therapies to slow the progression of atrophy have met with limited success, earlier intervention would be desirable, and could be possible if endpoints and biomarkers to assess progression early in the disease were available. By studying the epidemiology of AMD progression over 7 years, the proposed research will identify these critical biomarkers and develop a staging system for AMD which is essential to enable early intervention clinical trials for AMD.

PI_NAMEs: HAINES, JONATHAN L;PERICAK-VANCE, MARGARET A.;SADDA, SRINIVAS R (contact);STAMBOLIAN, DWIGHT EDWARD

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Age;age related;age related biomarkers;Age related macular degeneration;Age Years;Amish;Angiogenesis Inhibitors;Angiography;Atrophic;Background Diabetic Retinopathy;Biological Markers;Blindness;Calibration;Choroid;Choroidal Neovascularization;Classification;Clinic;Clinical;clinical practice;Clinical Research;Clinical Trials;cohort;Color;cost;Data;deep learning;Deposition;design;Development;Diabetic Retinopathy;digital imaging;Disease;Drusen;Early Intervention;effective therapy;effectiveness evaluation;Elderly;Epidemiology;epidemiology study;Evolution;Eye;Eye diseases;Film;follow-up;Functional disorder;Funding;Fundus;Genetic;Genetic Markers;genetic risk factor;Genetic Variation;geographic atrophy;high risk;Image;Imaging technology;improved;Individual;insight;Intervention;Intervention Trial;Knowledge;learning algorithm;macula;Methods;Modeling;Modernization;Multimodal Imaging;neovascularization;Nonexudative age-related macular degeneration;novel;Optical Coherence Tomography;Outcome Assessment;Patients;Phase;Phenotype;Population;population based;Population Study;prevent;Principal Component Analysis;Probability;progression risk;Protocols documentation;recruit;Research;Research Personnel;Resources;Retina;Risk;Risk Factors;risk variant;Series;Severities;Severity of illness;social;Staging;Staging System;statistical learning;success;System;Techniques;Testing;Therapeutic Trials;therapy development;three-dimensional visualization;Time;Uncertainty;United States;Validation;Visit

PROJECT_TITLE: Epidemiology of Biomarkers of AMD Progression


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE This application focuses on using genetically engineered mice and patient derived xenograft models of neurofibromatosis type 1 to characterize the role of the TAM family receptors in the initiation and progression of plexiform neurofibroma to malignant peripheral nerve sheath tumor. These studies will also test AXL inhibitory agents and other key small molecules in peripheral nerve sheath tumor growth and progression.

PI_NAMEs: CLAPP, DAVID W (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;Affect;analog;angiogenesis;Antitumor Response;Benign;Binding;Biological Markers;cancer predisposition;cancer stem cell;CDK4 gene;Cells;Cessation of life;Child;Clinic;Clinical;Clinical Data;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Complex;Development;effective therapy;efficacy evaluation;Family;FDA approved;Genetically Engineered Mouse;genome analysis;Genomics;Germ-Line Mutation;Growth;Human;Human Genetics;human subject;Immune;Immunologics;Immunotherapeutic agent;implantation;Individual;inhibitor;insight;Laboratories;Lesion;Link;LoxP-flanked allele;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant Neoplasms;man;Measures;MEK inhibition;MEKs;MERTK gene;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Neural Crest;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;new therapeutic target;NF1 gene;non-invasive monitor;Non-Malignant;novel;novel therapeutic intervention;Orphan;Orphan Drugs;overexpression;Participant;patient derived xenograft model;Patients;Peripheral Nerve Sheath Neoplasm;Persons;Pharmaceutical Preparations;pharmacodynamic biomarker;pharmacokinetics and pharmacodynamics;pharmacologic;Phase II Clinical Trials;phase II trial;Phenotype;Phosphotransferases;Plasma;Plexiform Neurofibroma;pre-clinical;premalignant;premature;prevent;Probability;Prognostic Marker;prognostic value;Proteins;receptor;Receptor Inhibition;Receptor Protein-Tyrosine Kinases;Receptor Signaling;response;Role;Sarcoma;Series;Serine;small molecule;small molecule inhibitor;stem cells;Syndrome;synergism;targeted treatment;Testing;Toxic effect;treatment response;tumor;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor Suppressor Genes;tumorigenic;Tyrosine Kinase Inhibitor;Tyrosine Kinase Receptor Inhibition;Work;Xenograft Model

PROJECT_TITLE: TAM receptor inhibition in NF1-associated peripheral nerve sheath tumors

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Clinical Research;Genetic Testing;Genetics;Health Services;Human Genome;Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project narrative Public Health Relevance PROJECT NARRATIVE: The purpose of the Fellowship In Genomics Outcomes Research (FIGOR) is for Genetic Counselor Scholars (GCS) to experience mentored research in a highly collaborative and supportive environment with 50% effort protected time for 24 months. GCS will gain experience in translational research skills in the areas of genomic sciences and genomic medicine, as well as the ethical, legal and social implications of these areas. The experience will simultaneously educate genetic counselors and scientists in the value of collaboration to maximize and broaden the impact of translational research.

PI_NAMEs: COX, NANCY J (contact);DUDEK, MARTHA

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Area;Basic Science;career;career networking;Certification;Climacteric;Clinical;Clinical Sciences;Collaborations;collaborative environment;Communication;Communities;Complement;coping;Data;Degree program;Development;Disease;Education;education planning;Environment;ethical, legal, and social implication;Evidence based practice;experience;Faculty;faculty mentor;Fellowship;Fostering;Funding;Future;Genetic;Genetic Counseling;genetic counselor;Genetic Diseases;genetic information;Genetic Phenomena;Genetic Research;genome sciences;Genomic medicine;Genomics;Goals;Grant;Growth;Healthcare;human genomics;Individual;innovation;Inpatients;Instruction;Intention;interdisciplinary collaboration;International;Journals;Knowledge;Leadership;Learning;Measures;Medical;Medicine;meetings;member;Mentors;Mentorship;Minority;next generation;Outcomes Research;personalized medicine;programs;public health relevance;Publishing;recruit;Registries;Research;Research Personnel;Resources;Rewards;Role;Science;Scientist;skills;social;Students;supportive environment;Time;timeline;Training;training opportunity;Training Programs;translational genomics;translational impact;Translational Research;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: FIGOR: Fellowship In Genomics Outcomes Research


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Chronic Pain;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE The delta opioid receptor (DOR)- kappa opioid receptor (KOR) heteromer expressed in pain-sensing neurons is a promising target for development of peripherally-restricted analgesic drugs to treat pain. In this project, a multifaceted and highly collaborative approach to identify small, drug-like molecules that selectively activate the DOR-KOR heteromer will be done to identify lead molecules for further development as potential pain therapeutics.

PI_NAMEs: CLARKE, WILLIAM P (contact);MCHARDY, STANTON FURST

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Absence of pain sensation;addiction;Adult;Adverse effects;Afferent Neurons;Affinity;Agonist;Analgesics;antagonist;antinociception;Binding;Cells;Chemicals;chronic pain;Clinical;collaborative approach;COVID-19 pandemic;daily pain;Dangerousness;Data;delta opioid receptor;Dependence;design;Development;drug-like compound;effective therapy;Effectiveness;efficacy evaluation;experience;Future;G-Protein-Coupled Receptors;high throughput screening;Human Resources;in silico;In Vitro;in vivo;Injections;kappa opioid receptors;Lead;Libraries;Life;Ligands;Local Anesthetics;Mediating;Motor Neurons;mu opioid receptors;neurotransmission;Nociception;Nociceptors;novel;Opioid;Opioid Analgesics;opioid epidemic;Opioid Receptor;Pain;Pain management;Penetrance;Peripheral;peripheral pain;Persons;Pharmaceutical Preparations;Phase;Physiological;programs;Property;Protomer;Rattus;receptor;Reporting;research clinical testing;screening;Sensory;Series;small molecule libraries;Structure;Structure-Activity Relationship;System;Testing;Therapeutic;Toxicology;Training;United States National Institutes of Health;Ventilatory Depression

PROJECT_TITLE: Identification of allosteric molecules for DOR-KOR heteromer-mediated peripheral analgesia

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Maternal Health;Mental Health;Mental Illness;Microbiome;Pregnancy;Serious Mental Illness;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The gut microbiome interacts with many common medications, with the ability to modify their efficacy for treating disease. We aim to uncover fundamental mechanisms underlying interactions between the gut microbiome and antidepressants, and how such interactions impact the effects of antidepressant treatments for maternal depression during pregnancy.

PI_NAMEs: HSIAO, ELAINE  (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: absorption;Address;adverse outcome;Affect;antepartum depression;anti-depressive agents;antidepressant effect;anxiety symptoms;Bacteria;Behavior;Behavioral;Binding;Biochemical;Brain;Cell Physiology;depressive symptoms;Disease;Drug Kinetics;Drug Screening;efficacious treatment;Epidemiology;fetal;Fetal Development;Fetal health;Fetal Tissues;Genetic Engineering;Gnotobiotic;gut bacteria;gut microbiome;gut microbiota;Human;Individual;Intervention;Major Depressive Disorder;maternal depression;Maternal Health;Maternal-Fetal Exchange;Measures;Mental Depression;metabolomics;Metagenomics;microbial;microbial signature;microbiome;microorganism interaction;mouse model;Mus;neurodevelopment;novel;obstetric outcomes;offspring;patient response;Pharmaceutical Preparations;Physiological;post pregnancy;postnatal;Pregnancy;pregnant;Pregnant Women;Proteins;Reporting;Research;response;Risk;Role;Selective Serotonin Reuptake Inhibitor;serotonin transporter;Shapes;Social isolation;Streptococcus sanguis;symptom treatment;Symptoms;Testing;Time;Tissues;transcriptomics;Transplantation;Variant;Woman

PROJECT_TITLE: Uncovering Microbial Modifiers of Antidepressant Responses during Pregnancy