ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hearing Loss;Neurosciences;Regenerative Medicine

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Damage to the spiral ganglion nerve leads to permanent deafness, and a cochlear implant is the most effective treatment for severe-profound deafness. However, cochlear implants are ineffective with neuronal degeneration, and regenerative medicine, such as direct neuronal reprogramming to replenish the damaged spiral ganglion neurons, holds enormous potential to cure deafness and improve cochlear implant outcomes. This grant explores approaches to advance cellular reprogramming of cochlear glial cells into induced spiral ganglion neurons using a new mouse model with selective ablation of spiral ganglion neurons, optimizing gene delivery into cochlear glial cells, and enhancing reprogramming efficiency by combining micro RNAs with neuronal transcription factors.

PI_NAMEs: SHIBATA, SEIJI B (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Ablation;Acoustic Nerve;Acoustic Stimulation;Acoustics;Acute;Address;adeno-associated viral vector;Adult;age related;age related changes;Apoptosis;Applications Grants;Auditory;Auditory Brain Stem Implants;auditory neuropathy;Automobile Driving;Brain;Bypass;career development;Cell Extracts;Cell Reprogramming;Cell Survival;Cells;Cessation of life;Child;Chromatin;clinically relevant;Cochlea;Cochlear Implants;Data;deaf;deafening;deafness;Development;Development Plans;diphtheria toxin fragment A;effective therapy;Epigenetic Process;experience;Fiber;Fibroblasts;Gene Delivery;gene therapy;Genes;Genetic Transcription;Glial Fibrillary Acidic Protein;Gliosis;Goals;Grant;Health;Hearing;hearing restoration;Homeostasis;Impairment;Implant;improved;In Vitro;in vivo;Induced Neurons;inducible Cre;Intervention;Knowledge;Labyrinth;Mesenchyme;MicroRNAs;mouse model;Mus;Muscle satellite cell;Natural regeneration;Neonatal;neonatal mice;Nerve;nerve damage;Nerve Degeneration;Neuroglia;neuronal cell body;Neuronal Differentiation;Neurons;novel;Outcome;overexpression;Parvalbumins;Patients;Performance;Persons;Phenotype;Play;pluripotency;Proliferating;Proliferation Marker;promoter;Public Health;regenerative;Regenerative capacity;Regenerative Medicine;Reporting;Research;response;response to injury;Role;Schwann Cells;Scientist;Sensorineural Hearing Loss;Serotyping;Signal Transduction;single-cell RNA sequencing;Somatic Cell;Source;Specificity;Speech;spiral ganglion;success;Supporting Cell;Surgeon;Technology;Testing;transcription factor;Transfection;transgene delivery;transgene expression;Transgenes;transmission process;Tropism;vector;Work

PROJECT_TITLE: Cellular reprogramming of cochlear glial cells to regenerate auditory neurons

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Community-based interventions to interrupt mycobacterium tuberculosis (Mtb) transmission are needed to reduce the considerable global burden of TB, but evidence on how to spatially target these interventions for increased feasibility and efficiency is lacking. I propose to add to the evidence base by (1) developing a tool to estimate the subnational burden of TB by integrating programmatic, mobility, and survey data from Uganda; (2) characterizing transmission within and across distinct but linked communities using genomic data from 3 studies in Uganda and South Africa; and (3) projecting the impact and cost-effectiveness of TB prevention and case finding interventions by fitting a mathematical model of Mtb transmission to data from a large study in South Africa. Combined with a strong mentorship team and institutional support, this award will position me as a leading independent researcher who combines diverse sources of both traditional and emerging epidemiological data with infectious disease modeling tools to answer tough epidemiological questions and inform smarter policy responses.

PI_NAMEs: RYCKMAN, THERESA  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acceleration;Area;Award;Bayesian Modeling;Big Data;career;career development;case finding;Cell Aggregation;Cellular Phone;Censuses;Cessation of life;Characteristics;Clinic;clinical care;Clinical Management;Communicable Diseases;Communities;community intervention;community transmission;cost;cost effective;cost effectiveness;cost estimate;Country;County;COVID-19;Data;Data Analytics;Data Sources;design;Detection;Development;Development Plans;diagnostic assay;Disease;disease model;Effectiveness;Epidemic;epidemiologic data;Epidemiology;epidemiology study;evidence base;experience;Faculty;Familiarity;fighting;Funding;Future;genomic data;Genomics;Geographic Locations;Goals;health care availability;Health Policy;high risk;Household;Human;Imagery;improved;Incidence;Infection;infectious disease model;innovation;insight;Institution;Interruption;Intervention;Investigation;Knowledge;Lead;lens;Link;Location;mathematical model;medical schools;member;Mentors;Mentorship;Modeling;Molecular Epidemiology;mortality;Mycobacterium tuberculosis;next generation sequencing;Notification;novel;Pathway interactions;Pattern;Persons;Policies;Policy Analysis;Policy Making;Population;Positioning Attribute;Prevalence;Prevention;Prevention approach;Preventive treatment;programs;Public Health;Records;Reproducibility;Research;research and development;Research Personnel;Resolution;Resources;response;Scientist;screening;skills;Source;South Africa;spatial epidemiology;success;Surveys;Techniques;Testing;tool;Training;transmission process;Tuberculosis;Uganda;Uncertainty

PROJECT_TITLE: Integrating genomic and spatial insights on Mtb transmission into policy-relevant models

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Experiences in childhood and adolescence (e.g., differential exposure to childhood adversity) contribute to racial inequity in risk for Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). Population distributions of these early life experiences, however, are themselves shaped by upstream, structural factors that remain underexplored in the AD/ADRD literature. The proposed research will be the first to examine the implications of federal, state, and local governmental spending priorities – as structurally intervenable exposures that condition early life environments – on overall risk for, and racial inequities in, midlife cognition and later life dementia, providing important information to support government officials in prioritizing investments that facilitate and sustain lifecourse health.

PI_NAMEs: DUARTE, CATHERINE  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Adolescence;Adult;Affect;age acceleration;Alzheimer's disease related dementia;Alzheimer's disease risk;career;Childhood;childhood adversity;Chronic;Clinical;Cognition;Cognitive aging;conditioning;County;Data;Data Set;Databases;Dementia;dementia risk;design;Development;Dimensions;Disparity;early life exposure;Education;Environment;Environmental Risk Factor;Epidemiology;Evaluation;evidence base;Expenditure;experience;Exposure to;federal policy;Funding;Future;Gender;Goals;Government Officials;Grant;Health;Health and Retirement Study;healthy aging;Imprisonment;Individual;Inequity;Investments;Jail;K-12 Education;Knowledge;late life;Legal;Legal system;Life;Life Cycle Stages;Life Experience;Link;Literature;Local Government;marginalization;Measures;Mediating;Mediation;Mentorship;Methodology;Methods;middle age;minority communities;Modeling;Modification;multidisciplinary;National Longitudinal Survey of Youth;novel;older adult;Outcome;Pathway interactions;Physiological;Population Distributions;Prevention;Primary Prevention;Prisons;prospective;Quasi-experiment;Race;racial disparity;racial minority;Research;Respondent;Risk;Risk Factors;Role;Schools;Secondary Schools;Sequence Analysis;SET Domain;Shapes;skills;social;social factors;Stress;structural determinants;Students;Testing;Time;Training;Variant;Work

PROJECT_TITLE: Structural determinants of healthy aging: Assessing the role of governmental spending priorities in early life on mid-life cognition, later-life dementia risk, and racial inequity therein

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Agent Orange & Dioxin;Cardiovascular;Contraception/Reproduction;Endocrine Disruptors;Estrogen;Heart Disease;Infertility;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Ovarian health and cardiovascular health are intimately connected; however, previous research has not adequately addressed how environmental contaminants that target both the ovary and the heart can intensify a toxicant’s adverse effects by disrupting the reciprocal interactions that occur between organ systems. This proposal will identify the molecular mediators underlying cardiovascular and ovarian toxicity following exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Together, these studies will contribute to our understanding of environmentally induced cardiac injury and help identify environmental sources of human infertility.

PI_NAMEs: KOSSACK, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adolescent;Adult;Adverse effects;Advisory Committees;Affect;Age;aged;angiogenesis;Apoptosis;Atherosclerosis;Binding;Biology;Blood;Blood - brain barrier anatomy;blood damage;Blood Vessels;Body System;Cardiac;Cardiac health;Cardiac Output;cardiogenesis;cardioprotection;Cardiotoxicity;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;career;cell type;Cells;cellular targeting;cerebrovascular;Compensation;congenital heart abnormality;Coronary heart disease;Data;design;Development;Dioxins;Disease;Disparity;Echocardiography;effective therapy;Electrocardiogram;Embryo;Environment;environmental chemical;Environmental Pollutants;Environmental Pollution;epidemiology study;Estrogens;Event;Exposure to;Female;Fertility;Fertilization;Foundations;Functional disorder;Funding;Gene Expression;Goals;Growth;Health;Heart;Heart Diseases;Heart failure;heart function;Heart Injuries;Hemorrhage;Histology;Histopathology;Human;human model;Hypertension;Impairment;Infertility;Injections;Injury;Institution;Ligands;male;Mammals;Mediating;Mediator;men;Mentors;Modeling;Molecular;Molecular Profiling;Molecular Target;Myocardial dysfunction;Nature;Nutrient;Oocytes;Organ;Ovarian;ovarian damage;ovarian dysfunction;Ovary;ovotoxicity;Oxygen;Pathology;Perfusion;Pericytes;Permeability;persistent organic pollutants;Phenotype;Play;Postmenopause;premature;Premenopause;programs;reproductive;reproductive development;Research;Research Personnel;Role;sex;Signal Transduction;single cell sequencing;skills;Source;System;Tachyarrhythmias;Testing;Tetrachlorodibenzodioxin;Toxic effect;toxicant;Toxicology;Training;transcription factor;vascular bed;vascular contributions;Vascular remodeling;Vocational Guidance;Woman;Work;Zebrafish

PROJECT_TITLE: Identifying critical mediators of ovarian and cardiovascular health

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K9)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Obesity;Pediatric

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Endocrine-disrupting chemicals (EDCs) such as phthalates are both obesogenic and neurotoxic, but studies have been conducted separately. No study has linked phthalates' obesogenic effects with their neurobehavioral toxicity in an integrated causal pathway – yet overeating is a behavior associated with poor inhibitory control and high reward processing. The proposed research will investigate the complex relationships among a mixture of phthalate biomarkers, childhood inhibitory control, and reward processing with obesity growth trajectories between 6–17 years to determine if they form a causal pathway to obesity.

PI_NAMEs: LANE, JAMIL MARLO (contact)

PROJECT_TERMS: 17 year old;6 year old;Address;Adolescence;Adolescent;Adolescent obesity;Adult;advanced analytics;Affect;Age;aged;Analytical Chemistry;Archives;Asthma;Behavior;Biological Assay;Biological Markers;Birth;Body fat;Body mass index;Body measure procedure;Brain;career;career development;Career Mobility;causal model;Chemicals;Child;Child Development;Child Health;Childhood;Cities;cohort;Complex;Computing Methodologies;Cross-Sectional Studies;Curiosities;Data;Data Collection;Dedications;Development;Diabetes Mellitus;Doctor of Philosophy;early childhood;early life exposure;Eating Behavior;Educational workshop;effective intervention;Endocrine Disruptors;Environment;Environmental Health;Epidemic;Epidemiology;executive function;Exposure to;fetal;Financial Hardship;Foundations;Funding;Future;Goals;Grant;Growth;health disparity;Heart Diseases;High Performance Computing;high reward;Hyperphagia;Individual;innovation;interest;International;Intervention;Investigation;Knowledge;Life;Link;longitudinal design;Longitudinal Studies;Measurement;Measures;Mediating;Mediation;Mediator;meetings;Mentors;Metabolic;Metabolism;Methodology;Mexico;minority children;Modeling;neurobehavior;neurobehavioral;neurodevelopment;neurotoxic;neurotoxicology;novel;Obesity;obesity development;Obesity Epidemic;obesity in children;obesogenic;Pathway interactions;Pediatrics;Performance;Phenotype;phthalates;Policies;Positioning Attribute;postnatal;prenatal;programs;Public Health;Research;Research Personnel;Research Proposals;reward processing;Risk;Role;Sampling;Science;Scientist;self esteem;skills;social;social stressor;Statistical Methods;statistics;Sum;symposium;Teenagers;tenure track;terephthalate;Testing;Time;Tooth structure;Toxic effect;Toxicology;Training;Training Activity;urinary;Urine;Work;Writing

PROJECT_TITLE: Phthalate Mixtures and the Interconnection of Child Neurobehavior and Obesity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) in acute myocardial infarction (AMI) is increasing exponentially yet mortality in this condition remains high. This work will define fundamental ventricular and vascular physiology in VA-ECMO and test novel approaches to mitigate increases in afterload and ventricular injury imparted by VA-ECMO. These results will provide urgently needed mechanistic insight into current and future management strategies to improve outcomes in patients with AMI associated cardiogenic shock.

PI_NAMEs: EVERETT, KAY D. (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acute;Acute myocardial infarction;Adverse event;Advisory Committees;Animal Model;Aorta;aortic valve;Blood Vessels;Cannulas;Cannulations;Cardiogenic Shock;Cardiology;Cardiovascular system;Career Choice;career development;Circulation;Clinical;Clinical Research;clinical translation;cost;Counterpulsation;Coupling;Data;Death Rate;Development;Development Plans;Devices;Discipline;electric impedance;Engineering;Extracorporeal Membrane Oxygenation;Femur;Funding;Future;Goals;Grant;hemodynamics;improved;improved outcome;Injury;innovation;insight;Intervention;Intra-Aortic Balloon Pumping;Left;mechanical circulatory support;Mechanics;Mediating;Medical;Medicine;Mentorship;Methods;model design;model development;Modeling;Molecular;mortality;Myocardial;Myocardial dysfunction;myocardial injury;novel strategies;Oxygen Consumption;Patients;Peripheral;pharmacologic;Physicians;Physiology;Positioning Attribute;Pre-Clinical Model;preclinical study;pressure;Pump;Reporting;Research;Research Institute;Research Personnel;Resistance;Respiratory Diaphragm;Scientist;skills;supportive environment;Systole;Testing;therapeutic target;Thoracic aorta;Time;Training;Vasodilator Agents;Ventricular;Work;Workload;Writing

PROJECT_TITLE: Modulation of Ventricular-Vascular Coupling in Veno-Arterial Extracorporeal Membrane Oxygenation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The majority (>90%) of the human genome consists of non-coding regions that do not directly yield proteins but are transcribed into RNA. Long non-coding RNAs (lncRNAs) represent a large class of these molecules (>170,000) that can have crucial regulatory functions in a variety of biological processes, yet the vast majority of lncRNAs remain completely uncharacterized. This proposal seeks to develop and apply photocatalytic proximity labeling technology and CRISPR-based phenotypic profiling to better understand the mechanisms of lncRNAs, in turn answering fundamental questions surrounding these transcripts in normal and disease biology and es- tablishing novel modalities in precision medicine.

PI_NAMEs: KNUTSON, STEVEN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Biological Process;Biological Products;Biology;Biotinylation;career;catalyst;cell behavior;cell growth;cell motility;Cell Physiology;Cells;Chemicals;Chemistry;Chromatin;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;CRISPR/Cas technology;design;Disease;DNA;DNA Probes;Engineering;Enzymes;Exclusion;experimental study;Future;Gene Expression;Genes;Genetic Engineering;Genetic Recombination;Genetic Transcription;Genome;Genomics;Goals;Guide RNA;Human Genome;In Situ Hybridization;in vivo;Individual;innovation;insight;interest;Knock-out;Knowledge;Label;MALAT1 gene;Malignant Breast Neoplasm;Maps;Measurement;Measures;Mechanics;Medicine;Metabolic;Methodology;Methods;Modality;Motility;Mutation;mutation screening;Neoplasm Metastasis;next generation;novel;novel strategies;Oncogenic;Open Reading Frames;Pathologic;Pattern;Peroxidases;Phenotype;Play;Postdoctoral Fellow;precision medicine;prime editing;protein function;protein structure;Proteins;Regulation;Research Proposals;Resolution;RNA;RNA-targeting therapy;Role;screening;Site;small molecule;Structural Biochemistry;Structure-Activity Relationship;Technology;Testing;Therapeutic;Tissues;tool;Training;Transcript;transcriptome;Untranslated RNA;Work

PROJECT_TITLE: Mechanistic Interrogation of Long Non-coding RNAs using Photocatalytic Proximity Labeling and CRISPR Phenotypic Profiling

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (KR)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Machine Learning and Artificial Intelligence;Microbiome;Nutrition;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Even in the absence of active inflammation, persistent symptoms are common in Crohn's disease (CD), result in worsened quality of life, increase risk for future opioid use, and are among the top drivers of healthcare expenditures in CD. Despite these significant challenges, evidence-based therapies do not exist due to lack of mechanistic understanding of this condition. The overall goals of this project are to identify how sulfur producing microbes may influence the host and whether diet may be a safe and effective treatment for improving persistent symptoms in CD.

PI_NAMEs: LEE, ALLEN A (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Acceleration;Adherence;Animals;Bacteria;Biopsy;cohort;Colonoscopy;common symptom;Consumption;Crohn's disease;Data;Data Set;Deterioration;Development;Diet;Dietary intake;Dietary Intervention;Dietary Sulfur;Disease remission;Drug Metabolic Detoxication;effective therapy;Enzymes;Epithelium;Esthesia;evidence base;Evidence based treatment;Functional disorder;Future;gastrointestinal;gastrointestinal symptom;Gastrointestinal tract structure;Gene Expression;Genes;Goals;Grant;gut microbiota;Health Care Costs;Health Expenditures;Histologic;Host Defense;host-microbe interactions;Hydrogen Sulfide;Hypersensitivity;Immune response;Impairment;improved;Inflammation;insight;intestinal barrier;Intestinal permeability;Intestines;Label;Lasso;Leukocyte L1 Antigen Complex;Machine Learning;machine learning framework;Mediating;Metabolic Pathway;metabolomics;metagenomic sequencing;Metagenomics;Microbe;microbial;microbial based therapy;microbial community;microorganism interaction;Mitochondria;mitochondrial dysfunction;Mucous body substance;Multiomic Data;Nociception;novel;Nutritional Study;opioid use;Outcome;Pathogenicity;Patient Outcomes Assessments;Patient Self-Report;Patients;persistent symptom;Physiology;Pilot Projects;potential biomarker;primary outcome;Production;Proteins;Quality of life;Questionnaires;Randomized;Reporting;Research;response;Risk;Role;Safety;secondary outcome;stool sample;Strategic Planning;Sulfate;Sulfur;Sulfur Metabolism Pathway;Symptoms;Technology;Testing;Toxic effect;transcriptome sequencing;United States National Institutes of Health;Urine;Visceral

PROJECT_TITLE: The role of sulfidogenic microbes in quiescent Crohn’s disease with persistent symptoms

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Babies who are born extremely premature commonly have low blood platelet counts and a high risk of bleeding, usually in the brain or lungs. For this reason, they commonly receive platelet transfusions to decrease the risk of bleeding, although a recent randomized trial suggested that premature babies who received less platelet transfusions had less bleeding and mortality than those transfused with a higher threshold. This has generated uncertainty among clinicians regarding the optimal platelet transfusion thresholds for extremely preterm infants, and this trial is specifically designed to address this uncertainty by evaluating if lower thresholds for platelet transfusions will lead to improved survival without bleeding among extremely preterm infants born at 23 to 26 weeks gestational age.

PI_NAMEs: PATEL, RAVI MANGAL (contact);SOLA-VISNER, MARTHA C.

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Address;Admission activity;Adoption;Adult;Age;Area;Awareness;Birth;Brain;Caring;Cessation of life;Child;comparative effectiveness;cost;Data;design;Enrollment;Erythrocytes;Europe;European;experience;extreme prematurity;Family;feasibility trial;Frequencies;Funding;Gestational Age;Goals;Hemorrhage;high risk;high risk population;Hospitalization;implementation science;improved;improved outcome;Incidence;Individual;Infant;Intracranial Hemorrhages;Intraventricular;Knowledge;Life;Lung;Measures;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;Neonatal Mortality;neonate;Outcome;outreach;Patients;Planets;Platelet Count measurement;Platelet Transfusion;Population;postnatal;Pregnancy;Premature Infant;preterm newborn;prevent;prophylactic;Publications;Randomized;randomized trial;recruit;Reporting;Research Infrastructure;Resources;Risk;secondary outcome;Site;Surveys;Testing;Thrombocytopenia;Transfusion;Uncertainty

PROJECT_TITLE: 1/2 Neonatal Platelet Transfusion Threshold Trial (NeoPlaTT)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR (JA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE People with chronic kidney disease (CKD) in rural areas have challenging experiences, and we need more research and work to improve their care. Many people with CKD need help to ask their doctors, nurses and other clinicians all of their questions about their disease, and treatment and share what matters most to them. In this research project, we will work with people with CKD (stages 4-5) in rural areas, along with their family, friends and clinicians, to customize, use and test a tool called an “agenda-setting intervention” to help them ask their clinicians important questions during their clinic visits.

PI_NAMEs: SAUNDERS, CATHERINE H (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Abate;Active Learning;Address;Adherence;Advocacy;Advocate;American;Area;Award;Caring;Chronic Kidney Failure;Client satisfaction;Clinic;Clinic Visits;Clinical;cognitive interview;Communication;Complex;COVID-19;Data;Death Rate;design;Disease;effectiveness trial;Elements;Emergency department visit;emotional symptom;empowerment;Equity;Ethnography;experience;Family;Feedback;flexibility;Friends;Funding;Geography;Goals;Grant;health inequalities;Hospitalization;Hybrids;implementation design;implementation science;implementation strategy;improved;Individual;Inequity;International;Intervention;intervention delivery;Knowledge;Laboratories;Language;Length;Location;Monitor;New England;novel;Nurses;Outcome;Palliative Care;Participant;patient oriented;patient-clinician communication;Patients;Persons;Pharmaceutical Preparations;physical symptom;Physicians;practice setting;Prevalence;primary outcome;programs;Quality of Care;Randomized, Controlled Trials;Reading;Regimen;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;research study;response;Rural;rural America;rural Americans;rural area;rural dwellers;Rural Health;Rural health equity;rural patients;second grade;secondary outcome;Self Management;Services;Site;Structure;symptom management;Symptoms;Techniques;Technology;telehealth;Telemedicine;Testing;therapy design;Time;tool;Training;Travel;urban area;Urban Community;Visit;Work;Writing

PROJECT_TITLE: Setting the Agenda: Empowering people with CKD in rural America through participatory research to develop, implement and trial a clinical visit agenda-setting intervention

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE: Lung cancer screening (LCS) can reduce lung cancer-related mortality by 20%, but only 5-10% of eligible individuals have received an initial LCS, with Black and Hispanic individuals less likely to be screened. The goal of this study is to partner with community stakeholders to jointly develop and pilot test a multi-component community health worker intervention targeting key barriers to improve LCS and tobacco treatment utilization. The proposed activities will lay the groundwork for a subsequent R01 grant, conducting a fully powered randomized clinical trial to establish CHWs as an evidence-based practice that will facilitate access to screening and reduce lung cancer mortality both overall and among underserved populations.

PI_NAMEs: NUNEZ, EDUARDO RAMON (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;arm;Awareness;Behavior Therapy;Black Populations;Black race;Cancer Etiology;career;Caring;Cessation of life;Clinical Trials Design;cohort;Communities;community advisory board;Community Health Aides;community organizations;Counseling;Dedications;design;Diagnosis;Disparity;disparity reduction;Education;Educational Materials;Eligibility Determination;Equity;Evaluation;Evidence based practice;Fright;Future;Goals;Grant;Health;health belief;health disparity;health equity;Health equity research;Health Services;Health Services Accessibility;Hispanic;hispanic community;Hispanic Populations;implementation science;improved;Individual;Infrastructure;Insurance;Intervention;K-Series Research Career Programs;Knowledge;Lead;Lived experience;long-standing disparities;low dose computed tomography;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Massachusetts;Measures;Mediator;Medicare/Medicaid;member;Mentors;Mission;Modeling;Modification;mortality;neighborhood disadvantage;Neighborhood Health Center;Outcome;Participant;patient engagement;patient oriented;patient outreach;Patient Recruitments;Patients;pilot test;Policies;Population Heterogeneity;President's Cancer Panel;primary care provider;primary outcome;Process;Protocols documentation;prototype;Provider;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;Reduce health disparities;Reporting;Research Personnel;Scientist;screening;screening disparities;Screening for cancer;screening program;secondary outcome;shared decision making;skills;smoking cessation;social stigma;Stigmatization;Testing;therapy design;Tobacco;Training;treatment as usual;Trust;Underserved Population;uptake;Work

PROJECT_TITLE: A community health worker intervention to improve lung cancer screening uptake in community health centers serving Black and Hispanic communities

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Lewy Body Dementia;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Lewy body disorders, a subset of Alzheimer’s disease and related disorders (ADRDs), are progressive, incurable, and the 14th leading cause of death in the United States. Because most persons with Lewy body ADRDs are hospitalized in their last 6 months of life with high rates of intensive, inappropriate care, hospital- based interventions are needed to improve end-of-life care quality for this growing population. The goal of this project is to improve prognostication and end-of-life care quality measurement in Lewy body ADRDs, which will be used to inform future interventions that promote improved care quality, more thoughtful resource allocation, and reduced Medicare spending at end-of-life.

PI_NAMEs: AAMODT, WHITLEY  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acute care;Address;Admission activity;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Applied Skills;Attitude;beneficiary;Biometry;Bradykinesia;Calibration;care preference;career;Caring;Cause of Death;Cessation of life;Clinical;cohort;comorbidity;comorbidity Index;Data;Death Rate;Dementia;design;Development;Dimensions;Discrimination;Disease;Disease Progression;Doctor of Philosophy;end of life;end of life care;Ensure;Epidemiology;epidemiology study;EuroQOL;Factor Analysis;falls;Foundations;frailty;Funding;Future;Goals;Grant;Hallucinations;Health;health belief;Health Services Research;Health system;high risk;Hospice Care;hospice environment;hospital care;Hospitalization;Hospitals;improved;indexing;Inpatients;instrument;Intensive Care Units;Intervention;K-Series Research Career Programs;Knowledge;Learning;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Life;Logistic Regressions;male;Malignant Neoplasms;Measurement;Measures;Medicare;Mentors;Mentorship;Modeling;mortality;mortality risk;motor symptom;Movement Disorders;Multiple System Atrophy;National Institute on Aging;Nerve Degeneration;Neurodegenerative Disorders;Neuroepidemiology;Neurologist;non-motor symptom;Online Systems;Outcome;Outcomes Research;Outpatients;palliative;Palliative Care;Parkinson Disease;Patient Care;patient oriented;Patients;Pennsylvania;Persons;pilot test;Population;Populations at Risk;Positioning Attribute;post-pandemic;predictive modeling;prognostic model;prognostication;Psychoses;Public Health;Qualitative Research;Quality Indicator;Quality of Care;Quality of life;Reporting;Request for Proposals;Research;Research Methodology;Research Personnel;Research Training;Resource Allocation;Review Literature;Risk;risk prediction model;Sampling;sex;skills;Specialist;success;supportive environment;Surveys;Symptoms;Target Populations;Techniques;Testing;Time;tool;Training;Treatment Efficacy;United States;Universities;Work

PROJECT_TITLE: Improving End-of-Life Care for Hospitalized Patients with Lewy Body Disorders

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Gastrointestinal diseases and their complications have a significant negative effect on public health and incur considerable health care utilization costs. Research supported by this Center grant is critically important to advance our understanding of the mechanisms that underlie digestive diseases. This new knowledge can lead to practical applications for the diagnosis, prevention, monitoring, and treatment of digestive diseases.

PI_NAMEs: LARUSSO, NICHOLAS F. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Acceleration;Achievement;base;Basic Science;Biology;career development;Cell Therapy;cell transformation;Cells;cellular imaging;Clinic;Clinical;Clinical Sciences;Clinical Trials;Collaborations;collaborative environment;cost;cost effective;Diagnosis;Digestive System Disorders;digital pathology;Direct Costs;Discipline;Disease;Educational Curriculum;Environment;Epigenetic Process;epigenomics;exome;Faculty;Feedback;Focus Groups;Fostering;Funding;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;Genetic;Goals;Grant;Growth;Health;health care service utilization;improved;individualized medicine;Inflammation;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;interest;Investigation;Investments;Knowledge;Liver;Manuscripts;member;Mentorship;Metabolism;Microfluidics;Microscopy;Midwestern United States;Monitor;motility disorder;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Pathogenesis;Pathway interactions;Patient Care;patient oriented;Patients;Peer Review;practical application;Prevention;Productivity;programs;Public Health;Publications;recruit;Research;Research Personnel;Research Support;Research Training;Resources;response;sabbatical;Scientific Advances and Accomplishments;Scientist;Services;Signal Pathway;Signal Transduction;Structure;symposium;Technical Expertise;Technology;Technology Transfer;Therapeutic;therapeutic target;Tissues;Training Programs;translational applications;Translational Research;Translations;Underrepresented Minority;Visit;Woman

PROJECT_TITLE: Mayo Center for Cell Signaling in Gastroenterology

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J4)]


NIH_SPENDING_CATS: Digestive Diseases

PI_NAMEs: SHAH, VIJAY H. (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Area;Award;base;Biology;career development;Clinic;Clinical;clinical center;Clinical Sciences;Collaborations;Communication;cost effective;Digestive System Disorders;Discipline;Educational Curriculum;Educational workshop;Ensure;Epigenetic Process;epigenomics;Equipment;exome sequencing;Faculty;Feedback;Financial Support;Fostering;Funding;Gastroenterology;Genetic;Goals;Grant;Hepatology;improved;Institution;instrument;Interdisciplinary Study;interest;International;Journals;Leadership;member;Mentorship;Methodology;Microfluidics;Microscope;Microscopy;Midwestern United States;Modification;National Institute of Diabetes and Digestive and Kidney Diseases;Occupational activity of managing finances;operation;Outcome;Peer Review;Persons;Process;programs;Reagent;Research;Research Personnel;Resource Allocation;response;sabbatical;Science;Scientist;Services;Signal Transduction;Standardization;Structure;symposium;Technology;Time;Translational Research;United States National Institutes of Health;Update;Visit

PROJECT_TITLE: Administrative Core


PI_NAMEs: ORDOG, TAMAS  (contact)

PROJECT_TERMS: Acceleration;Accountability;Applications Grants;Architecture;Biological Assay;Biological Process;Biology;Cells;Charge;ChIP-seq;Chromatin;chromatin immunoprecipitation;Cleavage Under Targets and Release Using Nuclease;Clinic;Complex;Consultations;cost;cost effective;Coupled;Data Analyses;Dedications;Democracy;design;Digestive System Disorders;digital;Dissociation;DNA;DNA Modification Process;Education;education resources;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Epitopes;Equipment;Evolution;experience;Experimental Designs;Extramural Activities;Feedback;Funding;Future;Gastroenterology;Genes;genetic information;Genetic Transcription;Genomics;histone modification;Human Resources;Immunoprecipitation;individualized medicine;Infrastructure;Inherited;innovation;Journals;Laboratories;laboratory development;Life Cycle Stages;Manuscripts;Maps;Mediating;meetings;member;Metabolic;Methodology;Methods;Molecular;mRNA Expression;nano-string;National Institute of Diabetes and Digestive and Kidney Diseases;Newsletter;next generation sequencing;Nucleosomes;Paper;Persons;Phenotype;Positioning Attribute;Price;Program Development;programs;Proteome;Proteomics;Publications;Publishing;Regulation;Reproducibility;Research;Research Personnel;response;RNA Splicing;Scientific Advances and Accomplishments;Scientist;Services;Signal Pathway;Signal Transduction;single cell analysis;Surveys;symposium;Technology;Time;Tissues;tool;Training and Education;transcription factor;transcriptome;transcriptomics;user-friendly;Variant;webinar;Writing

PROJECT_TITLE: Epigenomics and Spatial Biology Core


PI_NAMEs: MC NIVEN, MARK A. (contact)

PROJECT_TERMS: Biomedical Engineering;Bioprobe;Biosensor;Cell Physiology;Cells;cellular imaging;Charge;Coculture Techniques;Collection;Computers;Consult;Consultations;Coupled;Custom;Data Analyses;Development;Device Designs;Devices;Disease;Doctor of Philosophy;Education;Engineering;Epithelium;Equipment;experience;Experimental Designs;experimental study;fabrication;Faculty;Feedback;Fluorescence;Fluorescence Microscopy;Funding;Gastroenterology;Goals;Histology;Hour;Human Resources;Infrastructure;innovation;Institution;Instruction;Laboratories;Lipids;Liquid substance;live cell imaging;Liver;Manuscripts;member;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;microphysiology system;Microscope;Microscopic;Microscopy;morphometry;Neuroepithelial;novel;Nucleotides;optical imaging;Optics;organ on a chip;Organoids;Pancreas;paracrine;Perfusion;Physiological;programs;Proteins;Publications;Publishing;Reagent;real-time images;Research;Research Personnel;Resolution;Resources;response;Scientific Advances and Accomplishments;Services;Signal Pathway;Signal Transduction;Signaling Molecule;spheroids;Students;superresolution microscopy;System;Technology;three dimensional cell culture;Time;Tissues;tool;Training;two-dimensional;user-friendly;Work

PROJECT_TITLE: Microscopy and Microfluidics Core


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Liver Disease;Microbiome

PI_NAMEs: BOARDMAN, LISA ALLYN (contact)

PROJECT_TERMS: Anatomy;Area;Atlases;base;Bile fluid;biobank;Biological Specimen Banks;Blood;Cell Separation;cell transformation;Chromatin;Clinic;Clinical;Collection;Constitution;cost effective;Cryopreservation;Cryopreserved Tissue;Data;Development;Digestive System Disorders;digital;Disease;DNA;Emerging Technologies;Endoscopy;Enteral;Epidemiology;Epigenetic Process;exome sequencing;Feces;Freezing;Fresh Tissue;Funding;Future;Gastroenterology;Genotype;Germ Lines;Grant;Health;Health Services Accessibility;Hepatology;Histologic;host microbiome;Human;Human Microbiome;Human Resources;human tissue;improved;Individual;individualized medicine;Inflammation;Infrastructure;innovation;Institution;Institutional Review Boards;Laboratories;Liver;Liver diseases;member;Methods;microbiome research;Microfluidics;minority patient;Molecular;Molecular Genetics;molecular phenotype;multiple omics;Neurosciences;Online Systems;Operative Surgical Procedures;organizational structure;Organoids;Outcome;Pathology;Pathway interactions;patient derived xenograft model;Patients;pediatric patients;Plasma;Primary Cell Cultures;Process;programs;Proteomics;protocol development;Protocols documentation;Publications;recruit;repository;Research;Research Design;Research Personnel;Research Project Grants;Resources;Sampling;Scientist;Serum;Services;Signal Transduction;single cell analysis;single cell technology;Slide;Software Tools;Source;Specimen;Standardization;success;support tools;Surveys;Techniques;Technology;Tissue Banks;Tissue Procurements;Tissues;transcriptomics;Translating;Translational Research;user-friendly

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

PI_NAMEs: IBRAHIM, SAMAR  (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Award;base;Basic Science;career;career development;Categories;Clinic;Clinical;clinical training;Computational Biology;cost;Data;design;Digestive System Disorders;Direct Costs;Educational workshop;Eligibility Determination;Exclusion;falls;feasibility testing;Feedback;Fostering;Funding;Future;Gastroenterology;Goals;Grant;Hepatology;innovation;Institution;interest;Investments;journal article;Laboratories;Leadership;Letters;member;Mentors;Mentorship;Midwestern United States;Names;National Institute of Diabetes and Digestive and Kidney Diseases;Notification;Peer Review;Physicians;Postdoctoral Fellow;Principal Investigator;Process;programs;Research;Research Personnel;Research Project Grants;sabbatical;Scientist;Services;Signal Transduction;Source;Specific qualifier value;Testing;Training;Training Programs;United States National Institutes of Health;Wages;Work;Writing

PROJECT_TITLE: Pilot and Feasibility Program


PI_NAMEs: GORES, GREGORY J. (contact)

PROJECT_TERMS: Advisory Committees;Award;career development;catalyst;Chicago;Clinical Sciences;Collaborations;Communication;Communities;Computational Biology;Digestive System Disorders;Education;education resources;Educational Activities;Educational workshop;Electronic Mail;Environment;Epigenetic Process;Event;Extramural Activities;Faculty;Feedback;Fortification;Fostering;Funding;Gastroenterology;gastrointestinal;Genetic;Goals;graduate student;Grant;Infrastructure;Institution;interest;Journals;Leadership;lectures;meetings;member;Mentorship;Midwestern United States;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Newsletter;novel;Postdoctoral Fellow;programs;Research;Research Personnel;Research Training;Role;Rotation;sabbatical;Series;Services;Signal Transduction;symposium;synergism;Technology Transfer;Training Programs;Translational Research;United States National Institutes of Health;Universities;Update;Washington;web site

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Clinical Research;Machine Learning and Artificial Intelligence;Pediatric;Prevention

PHR: PROJECT NARRATIVE Post-hospital discharge mortality rates among young children aged <5 years in sub-Saharan Africa are as high as 3-18%, far outpacing the 0.1% rate we recently described in US children. Despite this immense disparity, there are currently no externally validated or implemented risk assessment tools to identify young children at risk for post-hospital discharge mortality in sub-Saharan Africa. The proposed research will assess the discriminatory ability of machine learning risk assessment tools for post-hospital discharge mortality, includes the first external validation study of risk assessment tools for post-hospital discharge mortality among young children in sub-Saharan Africa, and will elucidate the role of a novel biomarker of endothelial dysfunction to predict post-hospital discharge mortality among young children.

PI_NAMEs: REES, CHRISTOPHER A. (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Address;Africa South of the Sahara;age related;aged;Anthropometry;Area;Arginine;Assessment tool;Biological Availability;Biological Markers;biomedical informatics;Child;Child Health;Child health care;Child Mortality;Child Support;Childhood;Citrulline;Clinical;clinical biomarkers;clinical diagnosis;clinical practice;clinical predictive model;cohort;Collaborations;Communities;community acquired pneumonia;Consumption;Data;Data Analyses;Death Rate;Decision Aid;design;Development;Diagnosis;Disease;Disparity;Doctor of Philosophy;Emergency Medicine;endothelial dysfunction;Evaluation;experience;Foundations;Future;global health;Goals;gradient boosting;Growth;Health care facility;high risk;Hospitals;Impairment;impression;improved;Infant;Intervention;Kenya;Length of Stay;Liberia;Logistic Regressions;Machine Learning;Malaria;Medical Research;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;mid-career faculty;Modeling;mortality;mortality risk;multidisciplinary;neonate;Nested Case-Control Study;neural network;novel;novel marker;Nutraceutical;observational cohort study;Ornithine;Outpatients;Pediatric Research;Pediatrics;Physicians;Plasma;Population;Prevention;professor;prognostic;prospective;Prospective cohort;public health priorities;Public Health Schools;Research;Research Activity;Research Institute;Research Personnel;Resource-limited setting;Resources;Risk;Risk Assessment;risk stratification;ROC Curve;Role;Scientist;Sepsis;Sickle Cell Anemia;skills;Statistical Methods;surveillance network;Tanzania;Techniques;Testing;tool;Training;Training Activity;Universities;Validation;validation studies

PROJECT_TITLE: Advancing Approaches to Identify Young Children at Risk for Post-Discharge Mortality

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J3)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Eczema / Atopic Dermatitis;Food Allergies;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Peanut allergy affects one in fifty US children, and rates have increased disproportionately in Black and Asian populations. Timely peanut introduction in infants at high risk of peanut allergy involves a series of interdependent steps, from initial screening to peanut introduction, during a critical and short window of opportunity, with barriers along the way. We will explore determinants of timely assessment of peanut allergy and peanut introduction and identify associated barriers and facilitators to inform development and testing of a novel intervention involving virtual medical care to safely facilitate peanut introduction.

PI_NAMEs: FLOM, JULIE  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Age;Age Months;Allergy to eggs;Allergy to peanuts;Anaphylaxis;Applications Grants;Asian population;Asthma;Black Populations;burden of illness;career;Caregivers;Caring;Characteristics;Child;Child Nutrition;Childhood;Chronic Disease;Clinical;clinical care;Cluster randomized trial;Communities;Complex;Consensus;cost;Data;Data Analyses;design;Development;Disease;Disparity;Eczema;effective intervention;Electronic Health Record;Epidemiology;Epinephrine;Equilibrium;Equity;Ethnic Origin;Ethnic Population;Evaluation;experience;Family;Federally Qualified Health Center;food challenge;Food Hypersensitivity;formative assessment;Fright;Funding;Future;Goals;Guideline Adherence;Guidelines;health equity;Health equity research;Health Services Research;Health Technology;high risk;high risk infant;Hypersensitivity;Hypersensitivity skin testing;IgE;Immunologist;implementation barriers;implementation intervention;implementation science;improved;Individual;Inequity;infancy;Infant;Injectable;insight;Intervention;Knowledge;Laboratories;Learning Module;Life course epidemiology;Low income;marginalization;Mediating;Medicaid;Medical;Mentored Clinical Scientist Development Program;Mentorship;Methods;Morbidity - disease rate;multi-site trial;multilevel analysis;National Institute of Allergy and Infectious Disease;novel;nutrition;Oral;Patients;pediatrician;Perception;Perinatal;Population;Positioning Attribute;Pragmatic clinical trial;pragmatic trial;preference;Prevalence;prevent;Prevention;Prevention approach;preventive intervention;protective effect;Quality of life;Race;racial minority population;Randomized, Controlled Trials;Reaction;Recommendation;Research;Research Personnel;response;Risk;Risk Factors;screening;screening guidelines;Series;Serum;Site;skill acquisition;skills;sociodemographics;Solid;standard of care;Structure;study population;support tools;Telemedicine;Testing;therapy development;Training;treatment as usual;trial design;United States National Institutes of Health;virtual;virtual health;virtual intervention;virtual visit;Visit

PROJECT_TITLE: Optimizing Equitable Peanut Allergy Prevention among Infants at High Risk of Peanut Allergy

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Rehabilitation

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Humans with severe or profound hearing loss can regain the ability to hear and understand speech through the use of an auditory neuroprosthesis, a cochlear implant. Attaining adequate speech perception with a cochlear implant, however, does not happen instantaneously and understanding the precise sequences and mechanisms by which the brain, its circuits, and its neurons facilitate this vital adaptation remains incomplete. Here, we focus on cochlear implant use to expand our knowledge on fundamental mechanisms of neuroplasticity, and findings from our proposed research have potential far-reaching impact for cochlear implant users and developing general strategies for neurorehabilitation.

PI_NAMEs: HIGHT, ARIEL EDWARD (contact)

PROJECT_TERMS: Active Listening;Adult;Animal Model;Animals;Auditory;Auditory area;auditory pathway;Auditory Perception;Auditory system;auditory tracking;Award;Basic Science;Behavioral;behavioral study;Brain;career;Chalk;Clinical Sciences;Cochlea;Cochlear Implants;Collaborations;Complex;Counseling;Data;deaf;density;Detection;Development;Devices;Discrimination;Educational workshop;Electrophysiology (science);Environment;Esthesia;expectation;experience;Eye;gaze;Goals;Hearing;hearing restoration;Home;Human;human model;improved;improved outcome;in vivo;innovation;Interview;Job Application;Knowledge;Laboratories;Learning;Link;Location;longitudinal human study;machine learning method;Maps;Measures;Medical center;Mentors;Mentorship;Midbrain structure;Modeling;Monitor;neurological rehabilitation;Neuronal Plasticity;Neurons;neuroprosthesis;neuroregulation;Neurosciences;New York;novel;Occupations;optogenetics;Otolaryngology;Outcome;outcome prediction;Patient-Focused Outcomes;Perceptual learning;Phase;Physiological;Process;programs;Publications;Randomized;Rattus;Recruitment Activity;Rehabilitation therapy;Research;Rodent;Rodent Model;Running;Sensory;skills;social engagement;sound;Speech;Speech Perception;statistics;Stimulus;Synaptic plasticity;System;Thalamic structure;therapeutic target;Time;tool;Training;Translational Research;Universities

PROJECT_TITLE: Neuroplasticity and early cochlear implant use

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (MK)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

PHR: Project Narrative Rewarding experiences must be remembered clearly to guide healthy learning, but this memory process can be disrupted in disorders such as dementia and drug addiction. To address our limited understanding of how the brain amplifies the events surrounding reward in memory, this research will leverage large-scale recording technologies to uncover the neural dynamics involved in forming spatial reward memories in two key brain regions, the hippocampus and entorhinal cortex. By investigating what aspects of the rewarding experience are stored and how they are stored, this work will enhance our knowledge of normal memory function and provide insight into neural processes that could deteriorate in mental disorders.

PI_NAMEs: SOSA, MARIELENA  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TITLE: Neural circuit dynamics of spatial reward memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-P (02)]


NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE  The goal of this proposal is to reveal how broadly expressed gene-regulating proteins control distinct gene expression programs to shape different blood cell fate decisions by focusing on Runx proteins’ activities in early T cell development and megakaryocyte development. I aim to address my hypotheses that relationship with 3D chromatin structure and the availability of physically interacting co-factors instruct context-specific functions of Runx proteins. In addition, this proposal will test whether the principles underlying dynamic Runx activities apply to other multilineage-expressed regulators’ functions and show how these gene-regulating proteins provide precisely needed regulatory inputs to normal blood cell production but can cause hematologic pathologies when dysregulated.

PI_NAMEs: SHIN, BOYOUNG  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: 3-Dimensional;Address;Architecture;Automobile Driving;B-Lymphocytes;Behavior;Binding;Binding Sites;Blood Cells;Bone Marrow;career;Cell Culture Techniques;Cell Lineage;Cell Nucleus;Cell Physiology;cell type;Cells;chemokine;Chromatin;Chromatin Structure;cofactor;cytokine;Development;DNA;DNA Binding;Gene Expression;gene network;gene regulatory network;Genes;Genome;Genomics;Goals;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;In Vitro;leukemia;Mature T-Lymphocyte;Megakaryocytes;Megakaryocytopoieses;Mentors;Modeling;Molecular;MYB gene;Myeloid Cells;non-Native;novel;paralogous gene;Pathogenicity;Pathology;Pathway interactions;Pattern;Phase;Play;Positioning Attribute;Production;progenitor;programs;Proteins;recruit;Regulatory Element;Research;Research Personnel;Role;RUNX3 gene;Shapes;Signal Transduction;Site;Specific qualifier value;stem cell expansion;stem cells;System;Systems Development;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;tool;transcription factor;Work

PROJECT_TITLE: The molecular mechanisms underlying context-specific Runx factor functions in directing hematopoietic cell identity

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Access to health information exchange (HIE) is critical to ensuring that emergency care is maximally responsive to the unique needs of older adults with Alzheimer’s disease and related dementias (ADRD); however, prior research suggests that significant racial inequities in HIE may exist, exacerbating existing racial disparities in the care of older adults. The proposed study will 1) characterize racial inequities in emergency care quality, HIE connectivity, and HIE use, and 2) quantify the impact of HIE on ED care quality for adults with ADRD. This research is directly responsive to the National Institute on Aging’s 2020-2025 research goals to facilitate smoother care transitions for older adults, improve the interaction of older adults with the healthcare system, and understand and address drivers of health inequities and disparities related to aging and diseases such as ADRD.

PI_NAMEs: LIN, SUNNY C (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Academic Medical Centers;Accident and Emergency department;Accounting;accurate diagnosis;Address;Adult;Adverse drug event;African American;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;Asthma;Award;behavioral health;Biometry;Black American;Black race;career;Caring;Communication;Country;Data;data access;data exchange;Data Science;Data Set;Delirium;dementia care;Diagnosis;Diagnostic;Diagnostic Errors;digital;Disease;Doctor of Philosophy;Economics;Effectiveness;Electronic Health Record;Emergency Care;Emergency Department Physician;Emergency department visit;Ensure;Environment;Equity;Evaluation;Event;experience;Foundations;Goals;Health;health care disparity;health disparity;health equity;health inequalities;health information technology;Health Policy;Health Services;Healthcare Systems;Home;hospital readmission;Hospitals;Hypersensitivity;improved;Inequity;Informatics;Information Technology;Injury;insight;Institution;Lead;Length of Stay;Literature;Maps;Medical History;medical specialties;Medicare claim;Medication Errors;Mentorship;Methods;National Institute on Aging;neuroimaging;Not Hispanic or Latino;novel;Nursing Homes;older adult;Older Population;Outcome;Outcome Measure;Pain;Patient Care;patient population;Patients;Pattern;Persons;Pharmaceutical Preparations;Physical Restraint;Physicians;Policies;Problem behavior;Process;Process Measure;Provider;psychotic;Public Health;Public Health Informatics;Quality of Care;Race;racial disparity;Racial Equity;racial prejudice;Research;Research Activity;Research Personnel;Resources;Risk;Role;Science;sedative;Sepsis;Site;Skilled Nursing Facilities;skills;social;social learning;Stereotyping;Stroke;Structural Racism;Symptoms;System;Techniques;Time;tool;Training;Training Activity;Universities;Washington;Work

PROJECT_TITLE: Racial Equity in Health Information Exchange and Emergency Care Quality for Adults with Alzheimer's Disease and Related Dementia

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Cognitive training is a promising intervention for slowing/preventing AD/ADRD in at-risk individuals, including those with MCI, but evidence for robust transfer to untrained domains is mixed, and there is a poor understanding of mechanisms that lead to transfer. Mismatch between cognitive resources and task demands is thought to lead to transfer by increasing the efficiency with which existing resources can be applied to untrained tasks, but there have been few attempts to measure mismatch states that lead to transfer. This proposal aims to develop a conceptual and operational framework for quantifying biopsychological mismatch, measured using experience sampling and ECG measures within and across cognitive training sessions in MCI, with the goal of understanding and improving transfer effects using future personalized, scalable cognitive training programs that can reach those most in need for intervention in MCI.

PI_NAMEs: TURNBULL, ADAM  (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: absorption;Address;Adherence;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Asian;attentional control;behavior change;Behavior Therapy;biobehavior;Biofeedback;Biological;career;Clinical Trials Design;Cognitive;Cognitive aging;cognitive capacity;cognitive process;Cognitive Science;cognitive task;cognitive training;Communities;Computer Models;cost effective;Data;data harmonization;Data Set;design;dosage;Electrocardiogram;Ensure;Episodic memory;Ethnic Origin;Ethnic Population;executive function;experience;experimental study;flexibility;Future;Goals;group intervention;Health Disparities Research;health disparity;Hispanic;Impaired cognition;Impairment;improved;Individual;Individual Differences;Infrastructure;Intervention;Latino;Lead;Machine Learning;Measures;Mentored Research Scientist Development Award;Mentors;Methods;mild cognitive impairment;Modeling;Nonpharmacologic Therapy;Not Hispanic or Latino;novel;novel strategies;older adult;Participant;Patient Self-Report;personalized intervention;pharmacologic;Pilot Projects;Population;post intervention;Postdoctoral Fellow;pre-clinical;prevent;Process;processing speed;programs;Psyche structure;psychologic;Psychological Transfer;Psychophysiology;Race;racial diversity;racial population;Research;Research Personnel;Resources;Risk;Running;Sampling;Science;side effect;signal processing;Signal Transduction;skills;social culture;Task Performances;Time;Training;training data;Training Programs;training project;trial design;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Characterizing biopsychological mismatch during cognitive training in mild cognitive impairment as a means of improving transfer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Sleep disturbances are one of the primary risk factors and pathogenic drivers of Alzheimer's disease and age- related dementias (ADRDs). The goal of this proposal is to use a small molecule identified by a chemical library screen to understand the mechanisms of age-associated sleep disruption as a driver of ADRDs and to exploit them as therapeutic drug targets. This research will establish a critical framework for pre-clinical drug discovery for ADRDs.

PI_NAMEs: LY, SARAH  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Age;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Alzheimer’s disease biomarker;Amyloid;anti aging;Automobile Driving;Award;Behavior;Behavioral;Brain;Brain region;Caenorhabditis elegans;career;Cell Death;cell type;Circadian Rhythms;Cognitive deficits;cognitive performance;CRISPR screen;CRISPR-mediated transcriptional activation;Data;Data Set;Dementia;Disease;Disease Progression;Drosophila genus;drug discovery;Drug Screening;Drug Targeting;Electroencephalography;experimental study;extend lifespan;FOS gene;Functional disorder;Future;Gene Targeting;Genes;Genetic;Genetic Screening;Goals;Hippocampus;Image;improved;improved outcome;improvement on sleep;inhibitor;Label;Lead;life span;Link;Machine Learning;Maps;Mediating;Memory;Molecular;mouse model;Mus;Nerve Degeneration;neuron loss;Neurons;neuropathology;neuroprotection;neurotoxicity;novel;novel strategies;Outcome;Pathogenicity;Pathology;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;poor sleep;Postdoctoral Fellow;pre-clinical;prevent;Process;programs;Protein Inhibition;protein tyrosine phosphatase 1B;Regulation;Research;Risk Factors;Role;screening;Signal Transduction;Sleep;Sleep disturbances;Sleep Fragmentations;small molecule;small molecule libraries;Task Performances;tau Proteins;Technology;Testing;Therapeutic;Tissues;tool;Toxic effect;Training;translational potential;Video Recording;Virulence Factors;Work

PROJECT_TITLE: Functional interrogation of the role of PTP1B in Alzheimer's disease pathophysiology and sleep


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Higher social capital (resources rooted in social networks) is positively associated with cervical cancer screening among Latinas, but how this association operates by nativity status and how clinic-based social capital interventions can be implemented in safety-net settings to address cervical cancer disparities among this population has not been explored. This project aims to assess the relationship between social capital and health care delays, to inform the design and development of a clinic-based social capital intervention to increase cervical cancer screening and reduce delays in follow-up among Latina patients.

PI_NAMEs: GARCIA, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Advisory Committees;Affect;Award;Biometry;California;Cancer Control;cancer diagnosis;cancer epidemiology;cancer health disparity;cancer prevention;cervical cancer prevention;Cervical Cancer Screening;Characteristics;Clinic;cohort;Cohort Analysis;Communication;Communities;community clinic;community engagement process;community organizations;community research;Computerized Medical Record;Consensus;Data;Daughter;design;Development;Diagnosis;Disparity;Elements;Ethnic Population;experience;follow-up;Foundations;Funding;Future;Goals;Health;health care settings;Health Disparities Research;health disparity;Health Services Research;Healthcare;Human Papilloma Virus Vaccination;implementation framework;implementation process;implementation research;implementation science;implementation strategy;improved;Incidence;Individual;innovation;Intervention;Interview;large scale data;Latina;Latina Population;Latino;Logic;Low income;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurement;Measures;medical specialties;member;Mentors;Methods;Minority Groups;Modeling;mortality;Mothers;National Institute on Minority Health and Health Disparities;novel;Outcome;Patients;Phase;pilot test;Population;prevention practice;Process;programs;Provider;Questionnaires;racial population;Randomized, Controlled Trials;recruit;Research;Research Design;Research Personnel;Resources;safety net;Sampling;skill acquisition;skills;social capital;social culture;Social Network;Social support;sociocultural determinant;Surveys;Testing;theories;therapy design;Training;young adult

PROJECT_TITLE: A Multilevel Social Capital Approach to Address Cervical Cancer Screening and Follow Up Delays among Latinas in Safety-Net Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: SEATTLE

ORG_NAME: VA PUGET SOUND HEALTHCARE SYSTEM

ORG_STATE: WA

PHR: PROJECT NARRATIVE (RELEVANCE TO VETERANS) VA surgeons perform more than 4000 major lower limb amputations annually. These Veterans are among the 623,000 Americans who live with a major lower limb amputation, the majority of whom were of diabetic or dysvascular etiology (4 out of 5) and the remainder mostly due to trauma. Another several thousand, also of traumatic etiology, stem from the U.S. involvement in enduring military conflicts overseas. These Veterans have all experienced a profound change in their lives. They walk slower and fall more often. Many incur injuries to their residual limb. Few find wearing a prosthesis comfortable. Why? Because the current state-of-the-art prosthetic restoration is no peer of the natural limb. My clinically relevant research aims to improve their mobility, reduce their risk of injury, and enhance their comfort by using innovative approaches to marry new technology with artisanal practice.

PI_NAMEs: KLUTE, GLENN  (contact)

PROJECT_TERMS: Address;Adherence;Air;American;Ankle;ankle prosthesis;Anterior;Area;Behavior;Bibliography;Bionics;care delivery;career;Caregivers;Categories;Characteristics;Clinic;Clinical;clinical decision-making;Clinical Trials;clinically relevant;Code;Communities;Complex;Consensus;Continuing Education;Contralateral;Coupled;Couples;Coupling;Cumulative Trauma Disorders;Decentralization;deep learning algorithm;design;Devices;diabetic;digital;Distal;Educational Curriculum;efficacy evaluation;Elements;Environment;Etiology;expectation;experience;falls;fictional works;Focus Groups;foot;Funding;Gait;Goals;Group Meetings;Health Services Accessibility;Hearing;Household;Improve Access;improved;improved mobility;Incidence;Individual;Injury;injury prevention;innovation;International;Intuition;invention;Kinetics;Knee;Knowledge;Learning;Legal patent;Life Experience;limb amputation;limb loss;Limb Prosthesis;Limb structure;Lower Extremity;machine learning algorithm;Manuscripts;Marketing;Measures;Medical center;meetings;Microcomputers;Military Personnel;Modeling;Motion;Motor;Movement;movie;Muscle;new product development;new technology;next generation;novel;Patient-Focused Outcomes;Pattern Recognition;peer;Perforation;Persons;power consumption;pragmatic study;prevent;Property;prophylactic;Prosthesis;prosthesis fitting;prosthetic foot;prosthetic socket;Quality of life;randomized, clinical trials;Recommendation;rehabilitation research;rehabilitative care;Research;residual limb;restoration;Risk;Role;Rotation;Rural Community;Scanning;Science;Scientist;service delivery;Services;Shapes;Side;skills;Skin;Skin injury;Skin Temperature;soft tissue;Source;stem;Stress;Surgeon;Suspensions;System;systematic review;Techniques;Technology;Testing;Thermodynamics;Time;Torque;Torsion;Trauma;Ulcer;United States Centers for Medicare and Medicaid Services;Vacuum;Veterans;Walking;wearable device;Weight;Work

PROJECT_TITLE: Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: The primary cilium is a tiny, extracellular-facing organelle, with a distinct composition from that of the rest of the cell or plasma membrane, that coordinates diverse extracellular signals (i.e odorants, metabolites, light, neuropeptides, hormones) and converts them into coordinated cellular responses. Though primary cilia have been implicated in a number of pathologies including ciliopathies, diabetes, neural disorders, disrupted immunity, and cancer, the mechanisms by which cilia are built and process signals remain poorly understood. The goal of this proposal is to explore the role of the ciliary traffic protein TULP3 in coordinating both making a cilium and maintaining receptors inside the cilium and how understanding these functions applies in the biological context of immunity.

PI_NAMEs: TURN, RACHEL ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Address;Automobile Driving;Binding;Biological;Biological Models;Biology;Bone Marrow;Bone Marrow Cells;C-terminal;career;Cell Culture Techniques;Cell Cycle;Cell Maturation;Cell membrane;Cell Size;Cells;Chronic Disease;Cilia;ciliopathy;cilium biogenesis;Communication;Complex;constitutive expression;Coupled;Coupling;Cues;Data;Databases;Defect;Development;developmental disease;Diabetes Mellitus;Disease;Dissection;Epithelial Cells;Epithelium;Event;extracellular;Failure;Foundations;G-Protein-Coupled Receptors;Generations;genome wide association study;Goals;Grant;Health;Heart Diseases;Hematopoiesis;hematopoietic stem cell differentiation;Hematopoietic stem cells;Hormones;Human;immune function;Immune System Diseases;Immunity;Immunofluorescence Immunologic;immunoregulation;In Vitro;in vivo;insight;Interphase Cell;Investigation;Kidney Diseases;kinetosome;Leukocytes;Licensing;Light;Link;link protein;live cell imaging;loss of function;lymph nodes;Lymphatic System;Lymphocyte;Lymphoid Tissue;Malignant Neoplasms;Mammalian Cell;Maps;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Metabolism;Methods;Microscopy;Mitosis;Modeling;mouse model;Mus;mutant;Mutation;neural;Neuropeptides;neurotransmission;Neurotransmitters;novel;Obesity;Organelles;Parkinson Disease;Pathology;Pathway interactions;Patients;Phenotype;Phosphatidylinositols;phosphoproteomics;Play;polymerization;Polymers;Population;prevent;Process;progenitor;protein function;Proteins;Protocols documentation;receptor;recruit;response;Retina;Role;Serum;Shotguns;Signal Transduction;Site;Smell Perception;Sonic Hedgehog Pathway;Starvation;stem cell differentiation;Structure of ciliary processes;Structure of germinal center of lymph node;success;superresolution microscopy;Syndrome;targeted treatment;Testing;Time;Tissues;tool;trafficking;Training;Tubulin;Vertebral column;Vesicle;Vision;White Blood Cell Count procedure;Work

PROJECT_TITLE: TULP3 integrates essential ciliary functions


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Physical Activity;Prevention;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE A growing body of research demonstrates that physical activity may improve behavioral, cognitive, and emotional functioning among individuals with neurodevelopmental disorders. However, it is not known if exercise can improve outcome among individuals exposed to prenatal alcohol, a serious and global public health problem. The present proposal uses both clinical and basic science to understand the relationship between physical activity, neurocognition and mental health and will investigate whether physical activity can improve cognitive and emotional functioning following prenatal alcohol exposure.

PI_NAMEs: BAKER, JESSICA A (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adolescent;Aerobic Exercise;Affect;Alcohols;Animal Model;Anxiety;anxiety-like behavior;Attention;Attenuated;autism spectrum disorder;Award;Basic Science;behavior test;Behavioral;Behavioral Paradigm;Blood specimen;Brain;career;Child;Childhood;Clinical;Clinical Data;Clinical Research;Clinical Sciences;Clinical Treatment;clinically relevant;Cognition;Cognitive;cognitive development;cognitive function;cohort;Data;Data Set;Development;Diagnosis;Disease;effectiveness evaluation;Emotional;emotional functioning;Ethanol;Evaluation;executive function;Exercise;exercise intervention;experience;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Functional disorder;Funding;Goals;Health;Health Benefit;Hippocampus;human data;Hyperactivity;Immune;Immunologic Markers;Impairment;improved;improved outcome;Individual;innovation;Intervention;Intervention Studies;Language;Learning;Life;life span;Longitudinal Studies;Measures;Memory;Mental Depression;Mental Health;Mentorship;Modeling;Molecular;Motor;Motor Activity;National Institute on Alcohol Abuse and Alcoholism;Neuroanatomy;neurobehavioral;Neurocognition;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neuroimmune;neuropathology;neuroprotection;neurotrophic factor;Outcome;Pattern;Physical activity;Population;post intervention;pre-clinical;pre-clinical research;processing speed;programs;Public Health;Questionnaires;Rattus;Recording of previous events;Research;Research Personnel;Research Support;Research Training;Rodent Model;Running;Sampling;spatial memory;Strategic Planning;Surveys;Symptoms;Teratogenic effects;Testing;Therapeutic;Training;Translating;translational neuroscience;Translational Research;translational scientist;United States;United States National Institutes of Health;Variant;Youth

PROJECT_TITLE: Translational Research to Accelerate Interventions for Fetal Alcohol Spectrum Disorders: Evaluation of Physical Activity at Basic and Clinical Levels

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: In a national survey of Iraq and Afghanistan combat Veterans receiving VA medical care, anger difficulties were the most commonly reported reintegration concern, particularly among Veterans with PTSD. Problematic anger is associated with numerous negative psychosocial outcomes for Veterans, including discord in family relationships, aggression, road rage, unemployment, and suicide risk. Anger also interferes with progress in PTSD treatment, further highlighting the need for improving anger treatments for Veterans with PTSD. Despite many Veterans reporting a desire for anger management treatments, current available treatments are limited by low rates of engagement and high rates of dropout. An efficacious mobile intervention for anger may help to overcome some of the barriers that have kept Veterans from engaging in, or benefitting from, anger management therapy services and improve functional outcomes and community reintegration for these Veterans.

PI_NAMEs: DILLON, KIRSTEN HAWKINS (contact)

PROJECT_TERMS: Afghanistan;Aftercare;Aggressive behavior;Anger;anger management;Caring;Cohort Studies;combat veteran;Communities;community reintegration;cost;cost effective treatment;Data;Diagnosis;Dropout;effective therapy;efficacy evaluation;evidence base;Evidence based treatment;experience;Family;Family Relationship;Feedback;Functional impairment;functional improvement;functional outcomes;Goals;Habits;Health;Health education;Health Technology;High Prevalence;Hostility;improved;innovation;Intervention;Iraq;K-Series Research Career Programs;Legal;Legal patent;Measures;Mediating;Medical;Methods;mHealth;Military Personnel;mobile application;Modification;Morbidity - disease rate;mortality;Occupational;Outcome;Participant;pilot test;Post-Traumatic Stress Disorders;Prevalence;psychoeducation;psychosocial;psychosocial outcome;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Project Grants;Risk;Sampling;Self Care;Self Direction;Self-Injurious Behavior;Services;social;suicidal risk;Suicide;Surveys;Techniques;Technology;Time;Unemployment;Veterans;Violence

PROJECT_TITLE: A Randomized Controlled Trial of the Mobile Anger Reduction Intervention for Veterans

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Depression is a prevalent global health issue, and our understanding of its links to neuroinflammation opens new avenues for prevention and treatment. This research aims to use the cytomegalovirus (CMV) as a model to understand how neuroinflammation, which the virus can trigger, might lead to depression by disrupting key brain circuitry. Using cutting-edge genetic and neuroimaging methods, this research seeks to identify individuals at heightened risk, understand the underlying neurobiological mechanisms, and thus lay the foundation for an independent career in population immunopsychiatry focused on the neuroviral etiology of depression across the lifespan.

PI_NAMEs: ZHENG, HAIXIA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affect;Antibodies;Atlases;Award;Behavior assessment;biobank;Biological;Biological Markers;biotypes;Blood;Brain;brain circuitry;career;Cells;Chronic;Clinical;Cytomegalovirus;Cytomegalovirus Infections;Data;Data Analyses;Data Set;depressive symptoms;Development;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Early Diagnosis;Early Intervention;Educational workshop;effective intervention;Ensure;Environment;Etiology;experience;Foundations;Future;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic variant;global health;Goals;Grant;Health;Herpesviridae;IL6 gene;Immune response;Immunity;Immunoglobulin G;indexing;Individual;Individual Differences;Infection;Inflammation;Inflammatory;inflammatory marker;innovation;International;Interview;K-Series Research Career Programs;Knowledge;knowledge base;life span;Link;Literature;Measurement;Mental Depression;Mental Health;Mentored Research Scientist Development Award;Mentors;Methods;Modeling;Molecular;molecular marker;Mood Disorders;Nature;neural;neurobiological mechanism;Neurobiology;neuroimaging;neuroinflammation;neurotropic;Outcome;Participant;Pathway interactions;Patients;Persons;Pilot Projects;Population;Population Study;Prevention;Process;Property;Publishing;Questionnaires;Research;Research Personnel;Risk;Risk Factors;Role;Sampling;Scoring Method;serological marker;Serology;seropositive;Severities;Signal Transduction;skills;Sleep Disorders;Structure;Suicide;symposium;Symptoms;Testing;Tissues;Training;Viral;Viral Epidemiology;Virus;Virus Diseases;Vulnerable Populations

PROJECT_TITLE: Cytomegalovirus, Brain Alterations, and Depression: Decoding Neuroinflammatory Pathways for Effective Intervention

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Bacterial vaginosis is the most common gynecological disease in women of reproductive age and causes pregnancy complications including infection of the amniotic sac and preterm birth. Research on the most common bacterial species associated with bacterial vaginosis, Gardnerella spp., has been hampered due to the inability to make genetic mutations in these bacteria. We have discovered a way to make genetic mutations in Gardnerella spp., and the proposed studies would capitalize on this discovery by developing tools for making gene deletions, insertions, and single base changes as well as making gene constructs for studying gene expression and protein production and localization.

PI_NAMEs: DILLARD, JOSEPH P (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Actinobacteria class;Adhesions;Affect;Age;Amniotic Sac;Anaerobic Bacteria;Antibodies;Bacteria;Bacterial Vaginosis;base;Binding;Biological Assay;Cell Communication;cell envelope;Cells;Cholesterol;chromosomal location;Chromosomes;Circular DNA;Complement;Complex;constitutive expression;Cytolysins;Cytolysis;Deletion Mutation;design;Detection;Disease;DNA;DNA Methylation;DNA Sequence Alteration;dysbiosis;Dysuria;effectiveness evaluation;Electroporation;Epithelial Cells;Epitopes;Female Genital Diseases;Frequencies;Gardnerella;Gardnerella vaginalis;gene complementation;Gene Deletion;Gene Expression;Gene Proteins;Genes;Genetic;genetic manipulation;Genetic study;Genetic Transcription;Growth;Gynecologic;HIV;Human;Immune Evasion;Immune mediated destruction;improved;inducible gene expression;Infection;Insertion Mutation;Insertional Mutagenesis;interest;intraamniotic infection;Lactobacillus;LacZ Genes;Learning;Lipase;Measures;Methods;Microbial Biofilms;Mobiluncus;Mucous body substance;Mutagenesis;mutant;Mutation;Mycoplasma;Names;Neuraminidase;Nutrient;Oligonucleotides;Pain;Pathogenesis;Persons;Pilum;Plasmids;Point Mutation;Pregnancy Complications;Premature Birth;Prevotella;Process;Production;promoter;Prospective Studies;Proteins;Reagent;Reporter;reproductive;Research;Role;scaffold;sexual and reproductive health;Sexually Transmitted Diseases;Structure;success;Suicide;System;Testing;tissue/cell culture;tool;Toxin;transmission process;Vaginal Discharge;vaginal microbiome;Virulence;Virulence Factors;Woman;Work

PROJECT_TITLE: Genetic methods for studying Gardnerella virulence

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: FAMILY MEDICINE

ORG_STATE: CA

PHR: NARRATIVE The COVID Recovery Clinic at Keck Medicine (Keck CRC) of the University of Southern California (USC) has treated patients with Long COVID since 2020. In this proposal, Keck CRC will improve its current care delivery and symptom model, establish new models of service to expand services to more patients, create multidisciplinary education resources for healthcare providers, and collect and analyze standardized data on patient and clinic outcomes to inform ongoing modifications in care delivery.

PI_NAMEs: MCAULEY, CAITLIN HELEN (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Keck COVID Recovery Clinic Optimal Outcomes for Patients, a Comprehensive Assessment and Management Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-H (01)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention;Radiation Oncology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative The current project is designed to study radiation-induced coronary heart disease (RICHD), a major concern in cancer survivors receiving radiation therapy. With miniaturized human vessel tissues and novel mouse models, I will map how radiation exposure dysregulates the vascular health over time and correlate molecular changes to specific mutations in TP53 gene. The ultimate goal is to provide insights for the stratification of cancer patients based on their genetic risk for RICHD to improve patient outcomes post-radiation therapy.

PI_NAMEs: JAHNG, WON SUK  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: 3-Dimensional;Adhesions;Advanced Malignant Neoplasm;Advisory Committees;Animals;Apical;Biological Assay;Biology;Blood Vessels;Cancer Patient;Cancer Survivor;cancer therapy;career;CDH5 gene;Cell Death;Cell Line;Cell Separation;cell type;Cells;Chromosome Mapping;cohort;Collection;Complex;Coronary heart disease;CRISPR/Cas technology;Data;Data Set;Dependence;design;Diagnosis;disease prognosis;Dose;Echocardiography;Endothelial Cells;Endothelium;Engineering;Equus caballus;Event;experimental group;Exposure to;Female;Fostering;Gene Expression Profile;gene regulatory network;Genes;Genetic Population Study;Genetic Risk;genetic variant;Genetic Variation;genome editing;genome sequencing;Genotype;Goals;Health;Heart;Heterozygote;Histology;Homeostasis;Human;human disease;human induced pluripotent stem cells;improved;induced pluripotent stem cell;Inflammation;insight;intercellular communication;Ionizing radiation;irradiation;Knock-in;Link;Lysosomes;Malignant Neoplasms;Maps;Membrane;Mentors;Mentorship;Mesenchymal;MicroRNAs;miniaturize;Modeling;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;Normal tissue morphology;novel;Oncology;p53 Signaling Pathway;patient derived induced pluripotent stem cells;Patient-Focused Outcomes;Patients;Permeability;Phase;Phenotype;Porosity;precision medicine;Radiation;Radiation exposure;Radiation Oncology;radiation risk;Radiation therapy;Radiogenomics;Reporter;Research Personnel;Risk Factors;risk variant;Roentgen Rays;Role;Sampling;sex disparity;Sex Distribution;side effect;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Sorting;Stratification;Syndrome;System;Technology;Time;Tissue Engineering;Tissue-Specific Gene Expression;Tissues;TP53 gene;Training;Transactivation;transcriptomics;Transgenic Mice;Variant;whole genome;x-ray irradiation

PROJECT_TITLE: Unraveling the Role of p53 in Endothelium Homeostasis after Ionizing Radiation Exposure


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE In patients with acute kidney injury (AKI), proteinuria testing within 3 months of hospital discharge is a powerful but underutilized method to identify those at risk for subsequent renal function loss, morbidity, and mortality. We will study provider and patient facilitators and barriers to follow up proteinuria testing and evaluate the relationship between provider or patient AKI awareness with follow up proteinuria testing (Aims 1 and 2). We will also conduct a pilot trial to evaluate the feasibility and acceptability of an intervention to manage proteinuria after AKI hospital discharge (Aim 3).

PI_NAMEs: KWONG, YUENTING DIANA (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: acceptability and feasibility;Acute Renal Failure with Renal Papillary Necrosis;adverse outcome;Albumins;Awareness;barrier to testing;Benefits and Risks;Biological Markers;blood pressure control;California;career;Caring;Clinic;Clinical;Clinical Investigator;Clinical Trials;cohort;Cohort Analysis;Creatinine;Critical Care;Data;Data Analyses;design;Development;Dialysis procedure;Documentation;Education;efficacy testing;electronic health data;Electronic Health Record;epidemiology study;Evaluation;Event;experience;Fatigue;follow-up;Glucose;Goals;Guidelines;Health;high risk;Hospitalization;Hospitals;implementation science;improved;improved outcome;inhibitor;innovation;International;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;Kidney;Kidney Diseases;Knowledge;Laboratories;Lead;Longitudinal cohort;loss of function;Maps;Measurement;Medical;Medicine;Mentors;Mentorship;Methods;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrons;Outcome;Outcome Study;Outpatients;Output;Patient Care;Patient Compliance;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Persons;Physicians;pilot test;pilot trial;prevent;prospective;Proteins;Proteinuria;Protocols documentation;Provider;provider adherence;Proxy;Qualitative Methods;Recommendation;Recovery;Renal function;Renin-Angiotensin System;Research;Research Personnel;Resources;Risk;Role;San Francisco;Scientist;screening;Signal Transduction;skill acquisition;Sodium;Structure;Surveys;symporter;Testing;Training;transportation access;treatment as usual;trial design;Universities;Urine

PROJECT_TITLE: Improving proteinuria testing and management after acute kidney injury

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pregnancy;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Nigeria faces the highest global burden of maternal mortality, predominantly driven by hypertensive disorders of pregnancy (HDP) that also pose long-term cardiovascular risks. Leveraging our successful feasibility study on implementation of a postpartum BP monitoring program, we developed the HDP Implementation Bundle and plan to conduct a type 1 hybrid stepped wedge cluster randomized trial to evaluate its preliminary effectiveness in improving postpartum BP and its implementation using the RE-AIM framework. The candidate will gain expertise in dissemination and implementation science complementing her background in cardio- obstetrics and health policy to facilitate her growth as an independent physician-scientist with expertise in global cardio-obstetrics.

PI_NAMEs: MAHMOUD, ZAINAB  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Address;Adoption;Adverse event;Africa South of the Sahara;Award;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career development;Caring;Cessation of life;Cluster randomized trial;cohort;Country;critical period;Data;design;Detection;Development;Development Plans;Diastolic blood pressure;Discipline of obstetrics;dissemination science;Dizziness;Educational Intervention;Effectiveness;effectiveness outcome;Enrollment;Evaluation;Event;evidence base;Evidence based intervention;experience;Face;Fatality rate;Feasibility Studies;Focus Groups;follow-up;Fostering;Goals;Grant;Growth;Health Personnel;Health Policy;Healthcare;Heart failure;High Risk Woman;Home Blood Pressure Monitoring;hospital care;Hybrids;Hypertension;implementation barriers;implementation context;implementation evaluation;implementation framework;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Income;informant;innovation;insight;interdisciplinary approach;interest;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;Maternal Mortality;maternal outcome;meetings;Mentors;Methods;Modeling;Modification;Monitor;mortality;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nigeria;Outcome;Participant;participant retention;Patients;Perinatal;Phase;Physicians;Pilot Projects;Population;post implementation;postpartum care;Postpartum Hypertension;Postpartum Period;pregnancy disorder;prevent;primary outcome;Procedures;Program Acceptability;programs;Provider;Pulmonary Edema;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Research;Research Methodology;Research Priority;retention rate;Risk;Safety;Scientist;secondary outcome;Serious Adverse Event;Site;Special Event;Stroke;success;supportive environment;Syncope;Teaching Hospitals;tertiary care;Time;Training;Translational Research;treatment as usual;Treatment Protocols;Universities;Washington;Woman;women's treatment;World Health Organization

PROJECT_TITLE: Improving Maternal Cardiovascular Outcomes through the Implementation of a Hypertensive Disorders of Pregnancy Bundle in Nigeria

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]