NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Evidence-based interventions addressing unmet social needs of adolescents and young adults (AYAs) with cancer are critical to reducing psychosocial outcome disparities. Applying a novel conceptual framework, the goal of the proposed study is to adapt an established multi-component resilience program to target AYA social support needs and establish proof-of-concept for this adaptation. If successful, this program has the potential to improve AYA outcomes and create a promising paradigm for comprehensively addressing psychosocial needs of AYAs with cancer and other serious illnesses.

PI_NAMEs: FLADEBOE, KAITLYN MARIE (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adolescent Development;Adult;Age;Area;Assessment tool;base;Behavior;Behavior Therapy;Behavioral;Behavioral Model;Buffers;Cancer Control;cancer diagnosis;cancer therapy;career;Clinical Trials Design;Collaborations;Communication;Complement;coping;Data;design;Development;Distress;efficacy testing;efficacy trial;Elements;Emotional;Enrollment;evidence base;Evidence based intervention;experience;family support;Feedback;follow-up;Friends;Funding;Goals;high risk;improved;Individual;innovation;interest;Intervention;Intervention Trial;Learning;Length;Malignant Neoplasms;Manuals;Measures;Modeling;Monitor;Newly Diagnosed;novel;novel strategies;Obesity;Oncology;Outcome;outcome disparities;Pathway interactions;Patients;Phase;Phase Ib Trial;phase II trial;phase III trial;pilot test;Population;Postdoctoral Fellow;pre-doctoral;prevent;Problem Solving;Procedures;programs;promote resilience;Protocols documentation;psychological distress;psychosocial;psychosocial outcome;psychosocial wellbeing;Qualitative Research;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;Reporting;Research;Research Methodology;Research Training;resilience;Resources;Risk;Science;Scientist;secondary outcome;Self Efficacy;Site;skills;social;social deficits;Social outcome;social relationships;social skills;Social support;stress management;success;Support Groups;Supportive care;survivorship;theories;therapy development;Training;treatment arm;treatment as usual;Treatment Efficacy;uptake;Work

PROJECT_TITLE: Addressing Social Needs of Adolescents and Young Adults (AYAs) with Cancer


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Public Health Relevance Identifying the mechanisms responsible for weight regain among children and adolescents with obesity is of paramount importance. This study will advance clinical care by examining these mechanisms during pubertal development, understanding important sex differences, and identifying new targets for therapeutics aimed at prevention of weight or fat mass regain during this important phase of human development.

PI_NAMEs: RYDER, JUSTIN R. (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 15 year old;19 year old;actigraphy;Address;Adolescence;Adolescent;Adult;Automobile Driving;Behavioral;behavioral phenotyping;Biological;Biology;Body mass index;Body Weight decreased;Characteristics;Child;clinical care;Desire for food;Development;Dietary intake;Disease remission;doubly-labeled water;driving behavior;Dual-Energy X-Ray Absorptiometry;Eating Behavior;energy balance;energy efficiency;Energy Metabolism;experience;Fatty acid glycerol esters;Female;Female Adolescents;Gastric Inhibitory Polypeptide;ghrelin;Gonadal Steroid Hormones;Growth;gut-brain axis;Health behavior;Homeostasis;Hormonal;Hormonal Change;Hormones;Human Development;Indirect Calorimetry;Individual;individualized medicine;Intervention;islet amyloid polypeptide;Leptin;life span;Life Style Modification;Maintenance;male;Measures;Mediating;Metabolic;Neurosecretory Systems;new therapeutic target;Obesity;obesity in children;Pediatrics;Peptide YY;Phase;Physical activity;Play;Population;premature;preservation;prevent;Prevention;primary outcome;Process;Protocols documentation;psychosocial;Puberty;public health relevance;Questionnaires;Regulation;Replacement Therapy;reproductive;response;Rest;Role;Satiation;sex;Sex Differences;success;Testing;total energy expenditure;United States;Weight;weight maintenance;Work;Youth

PROJECT_TITLE: Adaptive Mechanisms Responsible for Weight Regain in Youth with Obesity and the Influence of Sex

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Bipolar cells are critical interneurons in the retina, which relay visual information from photoreceptors in the outer retina to the output neurons in the inner retina. This proposal is to study the mechanism and neuronal circuitry underlying visual signal transmission by bipolar cells. Knowledge gained from this study is of fundamental importance to our understanding of retinal function, as well as retinal dysfunction caused by diseases that impair synaptic transmission in the retina.

PI_NAMEs: ZHOU, Z JIMMY (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TITLE: Synaptic mechanisms and circuitry of retinal interneurons

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nanotechnology;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: ALLERDIA INC

ORG_STATE: CA

PHR: Narrative: Development of a highly sensitive and specific POCT testing asthma triggering allergic IgE IgE-mediated allergic asthma is the major type of asthmas that impacts 70% of all the asthmatics. The most relevant allergens triggering IgE-mediated allergic asthma are environmental allergens. Therefore, development of a more accurate, convenient, low-cost, rapid and point-of-care enabled IgE test capable of rapidly and accurately identifying allergic IgE by overcoming false positivity of the current IgE tests would be a key component in efforts to enhance healthy living and reduce minority health disparities.

PI_NAMEs: ABBASI, ASGHAR ;STRINGER, WILLIAM W;ZHANG, KE  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Address;Affinity;Alaskan;Allergens;Allergic;American Indians;anti-IgE;Antibodies;Asian population;Asthma;asthmatic;asthmatic patient;Binding;Biological Assay;Black race;Blood specimen;Cessation of life;Characteristics;Clinical;Clinical Research;Clinical Sensitivity;commercialization;Complex;cost;cross reactivity;design;Detection;detection sensitivity;detector;Development;Diagnosis;Disadvantaged minority;Economically Deprived Population;environmental allergen;Extrinsic asthma;falls;Goals;health care availability;health disparity;Hispanic;Histidine;Hospitalization;Hypersensitivity;IgE;Immunoassay;Label;Laboratories;Lateral;Liquid substance;manufacture;Measurable;Mediating;migration;Minority Groups;minority health disparity;Monoclonal Antibodies;nanoGold;novel;Pathway interactions;Performance;Phase;point of care;point of care testing;precision medicine;preservation;prospective;Prospective Studies;prototype;rapid diagnosis;Rapid diagnostics;rapid test;Recombinants;Reduce health disparities;Resources;response;Running;Sampling;Sensitivity and Specificity;Serology;Serum;Signal Transduction;Small Business Innovation Research Grant;socioeconomic disadvantage;Source;Specificity;System;technology platform;Testing;Time;Validation;Whole Blood

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (J1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Impaired physical function and frailty are important causes of morbidity and mortality in people with HIV, yet no pharmacologic therapies are currently approved for these conditions in any patient population. Tesamorelin is an FDA-approved medication that is safe and effective for treatment of abdominal fat accumulation in HIV, which we also have shown enhances muscle mass and quality. In the proposed study, we will investigate whether 24 weeks of tesamorelin, as an adjunct to exercise, will lead to short-term and sustained improvements in physical function, muscle mass/quality, quality of life, and exercise adherence among older individuals with HIV.

PI_NAMEs: ERLANDSON, KRISTINE MACE;FOURMAN, LINDSAY TARA (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: abdominal fat;Acceleration;Adherence;Age;Aging;aging population;antiretroviral therapy;arm;Attenuated;attenuation;Biological;Biology;Biometry;Biopsy;Body Composition;Body Weight decreased;care costs;Clinical;Clinical Trials;Colorado;Communities;cost;Data;Development;Double-blind trial;Dual-Energy X-Ray Absorptiometry;early experience;early onset;effective therapy;Elderly;equilibration disorder;Exercise;exercise adherence;exercise intervention;Exercise Physiology;Exhibits;falls;Fatigue;Fatty acid glycerol esters;FDA approved;Feedback;frailty;General Hospitals;General Population;Genes;high risk population;HIV;Home;hormone analog;Hormone secretion;Hospitalization;Image;Impairment;improved;Independent Living;Intervention;Life Expectancy;Liver;Massachusetts;Measures;Metabolic;Mitochondria;mitochondrial dysfunction;Modernization;Monitor;Morbidity - disease rate;mortality;Muscle;muscle form;Muscle Mitochondria;novel;older adult;Older Population;Outcome;Oxidative Phosphorylation;Participant;patient population;Persons;Pharmaceutical Preparations;pharmacologic;Phase;phase III trial;Phenotype;Phosphocreatine;Physical Function;physical impairment;Physiological;Physiology;Placebos;Polypharmacy;prevent;Prevention;primary endpoint;Proxy;Public Health;Quality of life;r-hGH-M;Randomized;Recovery;response;Risk;Role;Safety;Self Efficacy;SF-36;Somatotropin;Somatotropin-Releasing Hormone;standard of care;Surveys;Symptoms;Syndrome;Testing;therapeutic target;Thinness;Time;Translations;Treatment Protocols;Universities;uptake;Visceral;Visceral fat;Withholding Treatment

PROJECT_TITLE: Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH)

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Maternal Health;Mental Health;Pediatric;Pediatric - AIDS;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Zimbabwe’s HIV prevalence rate is among the highest globally, and cisgender women of reproductive age are disproportionately affected. Considering the increased risk of HIV acquisition and transmission during pregnancy, there is an urgent public health need to develop interventions that increase the use of efficacious HIV prevention strategies like PrEP in the antenatal context. A multi-level, problem-solving intervention that addresses barriers to PrEP adherence and persistence during pregnancy and through the postpartum transition among patients, their partners, and antenatal care providers could improve the health of pregnant persons, ultimately decreasing HIV incidence in Zimbabwe.

PI_NAMEs: MANGEZI, WALTER ;O'CLEIRIGH, CONALL MICHAEL (contact);STANTON, AMELIA M.

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Adopted;Affect;Africa South of the Sahara;Age;Agreement;AIDS prevention;antenatal;antenatal care;antiretroviral therapy;Area;Attitude;Awareness;Blood;care providers;Caring;cis-female;Clinic;Clinical;Communication;Communities;Dapivirine;Data;Depressed mood;design;Distress;Dryness;Education;Educational process of instructing;effectiveness/implementation trial;Eligibility Determination;emtricitabine;Epidemic;evidence base;experience;follow-up;food insecurity;Formulation;future implementation;Government;Health;High Risk Woman;HIV;HIV Infections;HIV Seronegativity;implementation outcomes;improved;Incidence;Individual;Infant;Injectable;Intervention;Interview;Knowledge;Late pregnancy;Link;Manuals;Maternal-Fetal Transmission;Measures;men;Mental Depression;Mental Health;Motivation;Oral;Outcome;Participant;Pathway interactions;patient level intervention;Patient Self-Report;Patients;Perception;Persons;post-traumatic stress;Postpartum Period;Poverty;pre-exposure prophylaxis;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention strategy;primary outcome;Problem Solving;problem solving therapy;programs;Provider;provider-level barriers;psychologic;psychological distress;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reproductive;Resources;Risk;routine care;Safety;secondary outcome;skills;skills training;social;social stigma;Social support;Specific qualifier value;Spottings;Suicide;Tenofovir;Testing;therapy adherence;Training;transmission process;treatment adherence;treatment as usual;trend;unintended pregnancy;uptake;Vaginal Ring;Violence;Woman;young woman;Zimbabwe

PROJECT_TITLE: TENDAI4PrEP: Adaptation of a problem-solving intervention to address individual and provider level barriers to PrEP uptake and adherence among pregnant persons in Zimbabwe

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Over half of the 6 million persons with opioid use disorder (OUD) in the United States also suffer from chronic pain, which reinforces a negative cycle of poor health outcomes and increased risk of illicit opioid use. We will test an evidence-based immersive mindfulness virtual reality intervention that has shown benefit in reducing pain and shows promise to reduce illicit opioid use within opioid treatment programs over 8 weeks. By testing the efficacy of the intervention within opioid treatment programs, this innovative study has the potential to change how opioid treatment programs deliver care to patients with chronic pain and OUD.

PI_NAMEs: PEREZ, HECTOR RUBEN (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Affect;arm;biological adaptation to stress;Caring;chronic pain;chronic pain management;chronic pain patient;classism;Cognitive;comorbidity;craving;Data;diaries;effectiveness testing;efficacy testing;Emerging Technologies;Enrollment;Environment;Equity;evidence base;Evidence based intervention;experience;heart rate variability;illicit opioid;Immersion;improved;innovation;Institution;Intervention;intervention effect;Machine Learning;Mediator;mindfulness;mindfulness intervention;Mood Disorders;Moods;multidisciplinary;new technology;New York;Opioid;opioid epidemic;opioid treatment program;opioid use;opioid use disorder;Outcome;Pain;Pain intensity;Pain management;pain processing;pain reduction;Participant;Patients;perceived stress;Persons;Phobias;Physiological;Pilot Projects;poor health outcome;Positioning Attribute;primary outcome;Procedures;racism;Randomized;Randomized, Controlled Trials;recruit;Risk;secondary outcome;Severities;Site;smart watch;Stress;Testing;Theoretical model;Therapeutic;treatment effect;Treatment Efficacy;underserved community;United States;virtual reality;virtual reality environment;virtual reality intervention;Visual;Vulnerable Populations

PROJECT_TITLE: Virtual Reality Treatment for Chronic Pain and OUD In Opioid Treatment Programs: A Randomized Controlled Trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Narrative  Although there are many anti-HIV medications in use, none target Rev, an essential viral protein needed to export certain forms of the viral RNA that are then translated into proteins. A critical property of Rev is its ability to bind to itself. Here we propose to use a previously developed cell-free assay to test ~125,000 drugs for inhibition of this property of Rev, hoping to identify at least a handful that have the qualities of interest and merit further testing.

PI_NAMEs: SUTTON, RICHARD  (contact)

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Acute;Address;analog;Anti-Retroviral Agents;Binding;Biochemical;Biological Assay;Catalysis;Cell Line;Cell Nucleus;Cells;Chemicals;cheminformatics;Chronic;clinical investigation;Clinical Trials;Collaborations;Collection;Complement;complement system;Coupled;Cytolysis;Cytoplasm;cytotoxicity;Dose;Drug Interactions;Drug toxicity;drug-like compound;Dryness;FDA approved;Firefly Luciferases;Future;gag Gene Products;Generations;genetic regulatory protein;Genetic Transcription;genomic RNA;Goals;high throughput screening;Highly Active Antiretroviral Therapy;HIV;improved;in silico;In Vitro;in vivo;Individual;inhibitor;innovation;instrumentation;interest;Introns;Lead;Length;Libraries;Life;luminescence;Messenger RNA;meter;Molecular;novel;Nuclear Export;Open Reading Frames;pandemic disease;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasma;Powder dose form;prevent;Process;Production;Property;protein protein interaction;Proteins;Regulator Genes;response;Response Elements;RNA;RNA Splicing;scale up;screening;small molecule;small molecule therapeutics;Specificity;stable cell line;Structure;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;Toxic effect;Transfection;Translating;Validation;vector;Viral;Viral Load result;Viral Proteins;viral resistance;viral RNA;Viremia;Virion;Virus;Virus Replication;Work

PROJECT_TITLE: Identification of HIV Rev-Rev interaction inhibitors by a high throughput, small molecule, cell-free screen

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE People living with human immunodeficiency virus (HIV) are at an increased risk of cognitive impairment with age and worse longitudinal health outcomes. The ultimate goal is to establish cerebrospinal fluid (CSF) derived cells as a unique resource for monitoring neuroinflammation and estimating clinical health outcomes in people living with HIV. This goal will be accomplished by contrasting macrophage activation dynamics in disease-relevant animal models and brain-associated immune cells derived from human CSF to identify mechanisms regulating neuroinflammation and uncover how the brain becomes susceptible to cognitive decline.

PI_NAMEs: HAYES, LINDSAY NICOLE (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acute;Address;Age;age acceleration;age related;Age Years;Age-associated memory impairment;aged;Aging;Alzheimer's disease model;Alzheimer's disease patient;Animal Model;antiretroviral therapy;Autopsy;Biological;Biometry;Brain;Brain imaging;Brain region;cell motility;Cell Separation;Cells;Cerebrospinal Fluid;chemokine;Chronic;chronic infection;Classification;Clinical;Clinical Pathology;clinical predictors;Clinical Research;clinically relevant;Cognition;Cognitive deficits;cognitive function;cognitive performance;Corpus striatum structure;Data;Data Science;density;design;Development;Disease;Early Diagnosis;Gene Expression;Genes;Genetic Transcription;Goals;Health;healthy aging;Heterogeneity;HIV;HIV Infections;HIV Receptors;HIV Seropositivity;Human;human disease;imaging study;Immune;immune activation;Impaired cognition;in vivo;Individual;Inflammation;Inflammatory;inflammatory marker;K-Series Research Career Programs;Laboratories;Macrophage;Macrophage Activation;Maps;Measures;Microglia;Modeling;Molecular;molecular marker;Monitor;mouse model;Mus;Myelogenous;Myeloid Cells;Nature;Nervous System Disorder;neural;Neurodegenerative Disorders;neuroinflammation;Outcome;Participant;Pathology;Pathway Analysis;patient stratification;Patients;peripheral blood;Persons;Phenotype;Population;Positioning Attribute;preclinical study;Predisposition;programs;Proteins;Publications;Publishing;Receptor Signaling;Regulation;Research;Resources;Risk;Risk Factors;sex;Shapes;Signal Transduction;single-cell RNA sequencing;Spatial Distribution;Stimulus;Therapeutic;Training;transcriptome sequencing;transcriptomics;Viral

PROJECT_TITLE: Tracking myeloid heterogeneity in mouse models and cerebrospinal fluid of HIV-suppressed individuals to classify neuroinflammation and identify molecular markers associated with clinical pathology

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_NAME: CAMBRIDGE HEALTH ALLIANCE

PHR: PROJECT NARRATIVE _RY_ _ _ The proposed project is relevant to public health because a more thorough understanding of both overall and equity-specific effects of Value-Based Payment (VBP) policy on Opioid Use Disorder (OUD) outcomes can inform state policy makers as they develop and implement VBP policies intended to improve the health outcomes, care quality, and value of care for Medicaid beneficiaries. The proposed project is relevant to the mission of the NIDA because it focuses on OUD, overdose, and medication for OUD; examines the effects of a novel financing strategy designed to improve care quality, access, and delivery; and assesses racial and ethnic equity in evidence-based treatment use.

PI_NAMEs: FLORES, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: Accounting;acute care;Address;Adoption;Alaska Native;American Indians;Area;Asian population;Attention;behavioral health;beneficiary;Black Populations;burden of illness;Caring;Categories;Cessation of life;comorbidity;cost;Cost Savings;Data;Death Certificates;design;Disease;Disparate;Emergency department visit;Equity;ethnic disparity;Ethnic equity;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;Evidence based treatment;Expenditure;experience;Fatality rate;follow-up;Future;Goals;HCV screening;Health;Health Care Costs;health care disparity;Health Policy;Health Services;Healthcare;hospital readmission;improved;Incentives;Individual;interest;Intervention;Latinx population;Light;Link;Literature;Managed Care Programs;Mediator;Medicaid;medical attention;medication for opioid use disorder;Minority Groups;Mission;Modeling;Morbidity - disease rate;National Institute of Drug Abuse;Natural experiment;New York;novel;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;payment;Persons;Pharmaceutical Preparations;physical conditioning;Policies;Policy Maker;Population;Population Heterogeneity;Premature Mortality;programs;Provider;Public Health;Quality of Care;Quasi-experiment;Race;racial disparity;Racial Equity;racial minority;Research;Research Design;Research Support;Risk;risk sharing;scale up;Services;Societies;stem;Substance Use Disorder;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Impact of the New York State Medicaid Value-Based Payment Model on Opioid Use Treatment and Equity

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cardiovascular;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Human Genome;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This research aims to uncover how radiation affects the heart differently in men and women due to sex hormone and how our genetic background play a role in radiation-induced cardiotoxicity (RIC). We will use a special technique called the "cell village" approach with human induced pluripotent stem cells (iPSCs) from 200 individuals to study how genetic variations and radiation exposure impact the transcriptome and epigenome in 3D cardiac organoids. Additionally, we will use mouse model to mimic long-term radiation exposure, aiming to pinpoint the genes responsible for sex-based disparities in RIC and their practical implications for cardiovascular health in irradiated individuals.

PI_NAMEs: CHICCO, ADAM J;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: 3-Dimensional;Accidents;Address;Affect;Animal Model;Animals;atomic bomb;Bioinformatics;Biology;capsule;Cardiac;Cardiotoxicity;cardiovascular health;Cardiovascular system;Cell Line;cell type;Cells;cohort;Collaborations;Colorado;Complex;Computing Methodologies;CRISPR/Cas technology;Data Set;Disparity;DNA Sequence Alteration;dosage;Dose;Dose Rate;Echocardiography;Endothelial Cells;epidemiology study;Epigenetic Process;epigenome;epigenomics;Estradiol;Estrogen Receptors;Estrogen Therapy;Estrogens;experimental study;Exposure to;Female;Fibroblasts;Functional disorder;functional outcomes;Gamma Rays;Gene Expression;Genes;Genetic;Genetic Identity;Genetic Polymorphism;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome-wide;Genotype;Gonadal Steroid Hormones;Harvest;Health;Heart;Histology;Homeostasis;Human;human induced pluripotent stem cells;human model;Image;Incidence;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;inter-individual variation;Intervention;Ionizing radiation;irradiation;Japanese;Knowledge;life span;male;Maps;men;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;Normal tissue morphology;novel;novel strategies;Nuclear power plant accident;Organism;Organoids;Ovarian Ablation;patient population;Patients;personalized risk prediction;Physiological;Physiology;Population;precision medicine;Predisposition;prime editing;Production;Proteomics;Quantitative Trait Loci;Radiation;Radiation Accidents;Radiation exposure;Radiation Protection;radiation response;Radiation Tolerance;Radiobiology;Radiology Specialty;Radiosensitization;Receptor Activation;Receptor Signaling;Research;Resolution;response;Risk Factors;Roentgen Rays;Role;Selective Estrogen Receptor Modulators;Serum;sex;Sex Differences;sex disparity;sexual disparity;Signal Transduction;Silastic;single cell genomics;single-cell RNA sequencing;Survivors;Techniques;Technology;Time;Transcription Initiation Site;transcriptome;transcriptomics;tumor;Universities;Virginia;whole genome;Whole Organism;Woman;XCL1 gene

PROJECT_TITLE: Elucidating Sex Differences in Radiation-induced Cardiotoxicity with Cell Village iPSCs

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 MR-I (M1)]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome

PHR: The mechanistic relationship between 3D genome folding, chromatin dynamics, and stability of epigenetic memory is unclear due to challenges of simultaneously measuring these parameters in single cells. As such, we have a limited understanding of how chromatin folding impacts epigenetic stability and how this effects development processes and disease. Drawing on recent advances in multiplexed microscopy and super resolution imaging, I aim to develop new imaging technologies to study the dynamic feedback between chromatin folding and epigenetic memory across time scales.

PI_NAMEs: MURPHY, SEDONA  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: 3-Dimensional;Acceleration;Advocacy;Affinity;Architecture;Award;Binding;Biochemical;Biophysics;Cell division;cell fixing;Cell Reprogramming;cell type;Cells;Cellular biology;Chromatin;Collaborations;Deposition;Development;Developmental Biology;Developmental Gene;Developmental Process;Disease;Distal;DNA-Protein Interaction;epigenetic memory;Epigenetic Process;epigenetic regulation;Equilibrium;expectation;Feedback;Frequencies;Funding;Future;Gene Expression Regulation;gene repression;Genetic;Genome;Heritability;Heterochromatin;Histones;Image;imaging modality;Imaging technology;innovation;Institution;Investments;Link;live cell imaging;Maintenance;Malignant Neoplasms;Masks;Measurement;Measures;Mediating;medical schools;Memory;Mentorship;Methodology;Microscopy;Modeling;Molecular Conformation;Motion;multiplexed imaging;nanoscale;Nature;Nucleosomes;Organoids;Phase;Polycomb;Positioning Attribute;Postdoctoral Fellow;predictive modeling;Process;programs;Proteins;Reader;recruit;Repression;Research;Role;Science;Shapes;Structure;success;superresolution imaging;synthetic biology;System;tenure track;Time;Transcription Coactivator;Transcriptional Activation;undergraduate student;Visualization;Wages;Work;Writing

PROJECT_TITLE: Spatial Regulation of Epigenetic Memory

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-E (70)]


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  It remains to be determined whether the central nervous system (CNS) harbors the replication-competent HIV. This study will define the latent HIV infection in the brain myeloid cells (BMCs) isolated from the fresh brains of people with HIV enrolled in the “Last Gift” Program receiving suppressive ART. We will characterize human BMCs, define the genotypes and phenotypes of BMC HIV, and define the epigenetic features of stable HIV reservoir in human BMCs by the state-of-the-art techniques, in which the tools and BBB-penetrating small molecules studied in the proposal can be developed to manipulate HIV from the CNS in the future.

PI_NAMEs: JIANG, GUOCHUN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Address;Animals;antiretroviral therapy;Apoptosis;Autopsy;BCL2 gene;Binding;Bioinformatics;Biological Assay;blood-brain barrier penetration;Brain;brain cell;CCR5 gene;CD4 Positive T Lymphocytes;Cell Separation;Cells;Central Nervous System;Chromatin;cohort;Collaborations;Data;Development;Enrollment;Epigenetic Process;epigenetic regulation;Ethics;Event;evidence base;Future;Genes;Genetic Transcription;Genome;Genotype;Gifts;Goals;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;Immune;immune activation;In Vitro;Infection;inhibitor;innovation;Knowledge;latent infection;Length;lonely individuals;Macrophage;MCL1 gene;Microglia;Modeling;Molecular;mouse model;Myeloid Cells;Nature;neuroinflammation;novel;novel strategies;NR4A2 gene;Outcome;Pathway interactions;Peripheral Nervous System;Persons;Phenotype;Physiological;Play;prevent;programs;Protocols documentation;Proviruses;Residual state;Resources;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;SIV;small molecule;Source;System;T-Lymphocyte;Techniques;Testing;Tissues;tool;transcription factor;Tropism;Viral;viral rebound;Viral reservoir;Virus;Virus Diseases

PROJECT_TITLE: Defining the HIV reservoir and latency mechanism in human brain myeloid cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: Project Narrative Dr. Hioe’s research explores the processes by which HIV and SARS-CoV-2 viruses interact with the host to elicit immune responses or cause infection and disease. The research has direct relevance to the VA and to Veterans. The VA is the largest provider of HIV care in the US. The Veteran population also has a higher demographic risk than the general population of developing severe disease after SARS-CoV-2 infection. Dr. Hioe’s research goal is to acquire knowledge that can be used to pave the way toward more effective prophylactic and therapeutic measures against HIV and SARS-CoV-2.

PI_NAMEs: HIOE, CATARINA E (contact)

PROJECT_TERMS: 2019-nCoV;Adherence;Admission activity;AIDS prevention;Anti-Retroviral Agents;Antibodies;Antigen-Antibody Complex;Antigens;Applications Grants;Appointment;Area;Award;Bacteria;Bacterial Proteins;Binding;Biological Assay;Book Chapters;career;Caring;Cells;Chronic;Clinical;Clinical Immunology;Collaborations;Communicable Diseases;Complement;cost;Country;COVID-19;COVID-19 pandemic;COVID-19 severity;COVID-19 vaccine;Dendritic Cells;design;Development;Disease;Disease Outcome;editorial;Educational process of instructing;Epitopes;Faculty;Foundations;frontier;Funding;Future;General Population;Glycoproteins;Goals;graduate student;Grant;Health;Healthcare Systems;Heterogeneity;high risk population;High School Student;HIV;HIV envelope protein;HIV vaccine;humanized mouse;IACUC;Immune response;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunology;in vivo;Infection;Infection Control;Interruption;Knowledge acquisition;Laboratory Research;Lectin;Mass Spectrum Analysis;Measures;Mediating;Medical center;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;military veteran;Modality;Molecular;molecular mass;mouse model;Mucous Membrane;Nature;neutralizing antibody;New York;New York City;novel;novel coronavirus;novel vaccines;pandemic disruption;Paper;Pathogenesis;Pathogenicity;Peptide Signal Sequences;Phagocytosis;Plasma;Play;Polysaccharides;post SARS-CoV-2 infection;Postdoctoral Fellow;Preparation;Process;professor;programs;Property;prophylactic;protective effect;Protein Glycosylation;Provider;Publications;Publishing;R24;Recovery;Reporting;Research;Research Peer Review;Research Personnel;Resources;Rest;Risk;Risk Factors;Role;Saliva;SARS-CoV-2 antibody;SARS-CoV-2 spike protein;Scientist;severe COVID-19;Specialist;Spike Potential;standard of care;Stream;Study Section;Techniques;Therapeutic;Training;Trust;undergraduate student;United States National Institutes of Health;uptake;Vaccination;vaccination strategy;Vaccine Design;Vaccines;Variant;Veterans;Viral;Viral Physiology;Viral reservoir;viral resistance;Virion;Virus;Work

PROJECT_TITLE: BLR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases;Zika Virus

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The proposed work will develop a platform for flavivirus vaccine development using a cloning approach with focused attenuating mutations in a conserved region of the 3’ untranslated region (UTR) of flaviviruses. The goal of the project is to use a common strategy of attenuation in the 3’ UTR to develop an attenuated vaccine approaches for endemic and emerging flavivirus infections. If completed as outlined, our approach will allow for rapid development of chimeric, attenuated flavivirus vaccines for emerging infections.

PI_NAMEs: BECKHAM, JOHN DAVID (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3' Untranslated Regions;Adult;Antibody Response;Antibody-Dependent Enhancement;Attenuated;Attenuated Vaccines;attenuation;Black-legged Tick;Brain;CD8-Positive T-Lymphocytes;Cell Culture System;Central Nervous System Infections;Cloning;Data;Dengue;Dengue Infection;Dengue Vaccine;Dengue Virus;Development;Disease;disease model;efficacy evaluation;Emerging infection;Environment;Exhibits;Female;Flavivirus;Flavivirus Infections;Goals;Hospitalization;Human;human disease;immunogenic;immunogenicity;Immunologics;Individual;Japanese encephalitis virus;Knockout Mice;Laboratories;Laboratory Study;male;Measurement;Mediating;Medical;Membrane;Modeling;mortality;mosquito-borne;mouse model;Mus;mutant;Mutation;neutralizing antibody;novel;Outcome;Outcome Measure;pathogen;Pathogenicity;Peripheral;Population;Powassan virus;preclinical development;Pregnancy;pregnant;primary outcome;Public Health;Publishing;Research;Resistance;Risk;RNA;Role;secondary outcome;Serotyping;Site;Spleen;Structural Genes;Structure;T cell response;Testing;tick-borne flavivirus;Translating;type I interferon receptor;Untranslated Regions;Vaccinated;Vaccination;vaccine candidate;vaccine development;vaccine efficacy;vaccine platform;Vaccines;Vertebral column;Viral;Viral Load result;Viremia;Virus;Virus Diseases;West Nile virus;Work;Yellow fever virus;Zika Virus;Zika virus vaccine;ZIKV infection

PROJECT_TITLE: Development of a vaccination platform for emerging flavivirus infections

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE This is a career mentoring award to support the PI, Dr. Ellen Eaton, of the University of Alabama at Birmingham to mentor trainees engaged in clinical research at the intersection of substance use and HIV. New proposed research will identify best practices to implement telemedicine for substance use service delivery in the Deep South.

PI_NAMEs: EATON, ELLEN FLORENCE (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Acceleration;acceptability and feasibility;Acquired Immunodeficiency Syndrome;addiction;Address;AIDS prevention;Alabama;Award;barrier to care;Behavior Disorders;Bypass;career;career development;Caring;catalyst;Climate;Clinic;Clinical;Clinical Research;Clinics and Hospitals;Color;Communicable Diseases;community engagement;comorbidity;Complex;COVID-19 pandemic;Data;Dedications;Deep South;design;digital divide;disorder prevention;diversity and inclusion;Drug user;early-career faculty;Epidemic;Equity;experience;Faculty;Faculty Recruitment;First Generation College Students;First Independent Research Support and Transition Awards;Focus Groups;Funding;future implementation;Goals;Grant;Growth;health care delivery;health equity;Health equity research;Health Personnel;Health Sciences;Healthcare;Hepatitis C;HIV;Hospitals;Hour;implementation framework;implementation science;implementation strategy;implementation trial;Infection;Infrastructure;innovation;Intervention;Interview;K-Series Research Career Programs;Link;Mainstreaming;Manuscripts;Maps;Medicaid;Medicine;Mentors;Mid-Career Clinical Scientist Award (K24);Needle-Exchange Programs;next generation;novel;Opioid;Pain;pandemic disease;patient oriented;patient oriented research;Patient Outcomes Assessments;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;Policies;Politics;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;preference;preventive intervention;programs;Public Health;Qualitative Research;racism;recruit;Research;Research Activity;Research Personnel;Risk;Rural;Rural Community;rural drug use;Science;Scientist;service delivery;Services;skills;Structure;substance use;Substance Use Disorder;substance use treatment;syndemic;Technology;Telemedicine;Testing;Time;Training;Training Activity;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Vulnerable Populations;Women's Group;Work;Writing

PROJECT_TITLE: HIV, Equity, and Addiction Training (HEAT) Program

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Assistive Technology;Bioengineering;Disability Research;Pain Research;Rehabilitation

ORG_CITY: CALABASAS

ORG_NAME: FLEX ORTHOPAEDICS, INC.

PHR: PROJECT NARRATIVE Injury or disease in the ankle and hindfoot can cause such pain and dysfunction that patients are driven to extreme, irreversible measures such as extensive joint fusion or amputation. Ankle-and-hindfoot fusion, the state-of-the-art treatment that is intended to treat these conditions, can leave patients with a limb that is alive and attached to their body, but unable to support even basic function. The objective of this project is to develop a new type of implanted device that restores natural ankle movement, thereby eliminating joint pain, restoring function and quality of life, and preventing unnecessary amputation.

PI_NAMEs: PETERSON, BRANDON  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Activities of Daily Living;Acute;Affect;Amputation;Animal Model;Animals;Ankle;Architecture;Arthralgia;Arthritis;Arthrodesis;arthropathies;Articulation;Artificial Leg;Award;Biological;Body Fluids;bone;bone loss;Caring;Clinical;Complex;Contracts;Custom;Data;Deformity;Degenerative polyarthritis;design;Device Approval;Devices;diabetic;disability;Disadvantaged;Disease;Elbow;Elements;Engineering;Etiology;Face;Failure;Fatigue;Feasibility Studies;flexibility;foot;foot bone;Freedom;Functional disorder;functional outcomes;functional restoration;Gait;Goals;Grant;Human;Implant;implantable device;improved;Industrialization;Injury;innovation;invention;joint injury;Joints;Knee;Laboratories;Leg;Leg Injuries;Legal patent;life span;Light;limb loss;Limb structure;Literature;manufacturing process;Measures;Mechanics;Motion;Movement;Muscle;Nail plate;Necrosis;novel;operation;Orthopedics;Outcome;Pain;Particulate;Pathology;Patients;Performance;Periodicity;Phase;Physiological;preclinical study;Preparation;prevent;Prognosis;Property;prosthetic socket;prototype;Publishing;Quality of life;reconstruction;Replacement Arthroplasty;Research;research and development;research clinical testing;Resected;Risk;Robot;Safety;simulation;Skin;Slide;Small Business Innovation Research Grant;Structure;Surface;Talus;Technology;Testing;Tissues;Translating;Traumatic injury;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: A COMPLIANT ANKLE ENDOPROSTHESIS TO TREAT ANKLE-HINDFOOT PATHOLOGY

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-A (11)]


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative: HIV-1 envelope glycoproteins (Env) are the only viral antigens exposed to the host environment and are the main targets for therapeutic and prophylactic measures to control HIV-1 infection. The Env is heavily glycosylated and these glycans influence both immunogenicity and antigenicity of the protein; making Env glycans a major component of vaccine design. This study will identify the site-specific glycosylation of native HIV-1 Env and identify mechanisms that can be applied to engineer Env immunogens with correct glycosylation, native epitope presentation and improved immunogenicity.

PI_NAMEs: UPADHYAY, CHITRA  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Affect;Alteplase;Amino Acids;Animal Model;Antibody Formation;Antigens;Binding;Biogenesis;Biology;Cells;Chronic;clinically relevant;Complex;cross reactivity;Data;design;Development;Endoplasmic Reticulum;Engineering;Environment;Epidemic;Epitopes;Exposure to;flexibility;Galactose;Genetic Polymorphism;Glycoproteins;glycosylation;Goals;Golgi Apparatus;gp160;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Hybrids;Immune response;Immunization;immunogenicity;imprint;improved;in vivo;Individual;Infection;innovative technologies;Knowledge;Link;Mannose;Measures;Mediating;Molecular Chaperones;Molecular Conformation;neutralizing antibody;Pathway interactions;Pattern;Peptide Signal Sequences;Phenotype;Play;Polysaccharides;Post-Translational Protein Processing;prevent;Process;Property;prophylactic;Protein Biosynthesis;protein folding;Proteins;Publishing;Research Personnel;response;Role;Shapes;Site;Structure;Surface;targeted treatment;Time;tool;Translations;Vaccination;vaccination strategy;vaccine candidate;Vaccine Design;vaccine trial;Vaccines;Variant;Viral;Viral Antigens;Virion;Virus

PROJECT_TITLE: Harnessing native glycosylation to improve immunogenicity of HIV-1 Env immunogens

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative People using HIV self-testing (HIVST) need access to quality HIV-prevention programming, including education and exploration of pre-exposure prophylaxis (PrEP) - an effective biomedical prevention tool that continues to expand in choices and access points in the US. HIVST and PrEP are both central to ending the HIV epidemic, but presently they are not linked together in a systematic way. To address the critical need for PrEP programming to accompany HIV self- testing (HIVST), our study will work with experts and HIVST users to develop and pilot a novel, interactive, mobile friend PrEP decisional-aid website that helps to raise awareness around PrEP and guides people through a PrEP-decision- making process that matches their needs and values, and links people to resources for local or online PrEP.

PI_NAMEs: AMICO, KATHY RIVET  (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;Advisory Committees;Age;AIDS prevention;arm;Awareness;Caring;Collaborations;Communities;community consultation;Conflict (Psychology);cost;COVID-19 pandemic;Data;Decision Aid;Decision Making;design;Development;Diagnostic Reagent Kits;directed attention;early experience;Education;Educational Materials;efficacy trial;Epidemic;Equity;Evaluation;Exercise;experience;expiration;follow-up;Frequencies;Friends;Goals;Growth;Guidelines;Health;health disparity;Healthcare;HIV;HIV Seronegativity;Home;Human immunodeficiency virus test;Hybrids;improved;Individual;innovation;International;Interview;Knowledge;Link;Logistic Regressions;marginalized community;Measures;Medical;member;Metadata;Methods;Modeling;novel;Online Systems;Participant;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Persons;Pilot Projects;Population Heterogeneity;post-COVID-19;post-pandemic;pre-exposure prophylaxis;prevent;Prevention;prevention service;primary outcome;Process;Program Acceptability;programs;Protocols documentation;Psyche structure;Randomized;Recommendation;recruit;Reporting;Research;Resources;Role;satisfaction;secondary outcome;Self Administration;Self Direction;self testing;Services;Site;social stigma;success;Surveys;Taxes;Technology;Test Result;Testing;testing services;therapy development;Time;time use;tool;underserved community;uptake;virtual;web site;Work

PROJECT_TITLE: A self-administered PrEP Decisional Aid for dissemination with HIV self-test kits (DASH)


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Our research is relevant and significant to public health because it focuses on social determinants of health, which contribute to a wide range of health outcomes across the U.S., tailored to an often-understudied community with direct applications to patients with HIV. By leveraging qualitative methods, community collaborations, and the EHR, our line of research can elucidate social determinants of health from patient, clinician, and outcomes perspectives, while addressing the need for culturally tailored social determinants of health in Indigenous and other marginalized communities. Our proposal addresses NLM and NIMHD’s focus on developing analytic methods to better to better understand indicators, behavioral and lifestyle characteristics, and other underlying causes of health disparities with a commitment to building community collaborations.

PI_NAMEs: BEAR DON'T WALK, OLIVER JOHN (contact)

PROGRAM_OFFICER_NAME: WANG, YANLI

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;analytical method;Appointment;Artificial Intelligence;Award;Behavioral;biomedical informatics;career;Caring;Categories;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;Collaborations;Communities;community advisory board;community based participatory research;community building;community collaboration;community engagement;community research;community-centered;Competence;Data;Data Analyses;demographics;Diagnosis;direct application;Discrimination;Elderly;Electronic Health Record;electronic structure;Empirical Research;Ensure;Environmental Exposure;Ethics;experience;Faculty;food security;Foundations;Funding;Future;Gender;Goals;Health;health data;health disparity;health equity;health organization;HIV;HIV Infections;Housing;Human;immunodeficiency;Indigenous;indigenous community;Information Dissemination;innovation;intergenerational;Internal Medicine;Interview;Lead;Life;Life Style;Machine Learning;machine learning model;marginalization;marginalized community;marginalized population;Measures;medical specialties;mentoring community;Mentors;Mentorship;Methods;Modeling;multidisciplinary;National Institute on Minority Health and Health Disparities;Natural Language Processing;Nurses;Outcome;Patients;Persons;Phase;Politics;Population;Positioning Attribute;Postdoctoral Fellow;Poverty;pre-doctoral;programs;Provider;Public Health;Qualitative Methods;Qualitative Research;Race;Recording of previous events;Records;Reporting;Research;Research Methodology;Research Personnel;Resource Informatics;Risk;Role;Rural;Shapes;skills;social;social culture;social group;social health determinants;social structure;Social Work;Source;structured data;success;tenure track;Text;Training;transgender women;Trauma;tribal community;United States National Library of Medicine;Viral;Viral Load result;Walking;Work

PROJECT_TITLE: Collaboratively Identifying Population-Specific Social Determinants of Health for Indigenous Patients Living with HIV: From Patient Perspectives to the Electronic Health Record

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE Despite the efficacy of combined antiretroviral therapy (cART), the development of HIV-1 associated neurocognitive disorders (HAND) is a serious clinical complication in AIDS patients. The mechanisms underlying HAND are underdeveloped, and the current cART regimens are insufficient to inhibit the progression of HAND. We propose to elucidate the role of extracellular vesicles (EVs) on brain microvascular endothelial mitochondria in the development of HAND and evaluate the clinically tested mesenchymal stem cell-derived EVs to prevent neuropathogenesis in the HIV-1 infected humanized mice model. 1

PI_NAMEs: CHANDRA, PARTHA  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Aging;Animals;antiretroviral therapy;Area;arteriole;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood capillaries;Blood flow;blood-brain barrier disruption;blood-brain barrier function;Brain;brain dysfunction;brain endothelial cell;brain health;cell injury;Cells;Cerebral endothelium;cerebral microvasculature;Cerebrovascular Trauma;Cerebrum;Chronic;Circulation;Clinical;clinically relevant;Complication;Cultured Cells;Data;Development;Disease;Dynamin;Endothelial Cells;endothelial dysfunction;Endothelium;Etiology;Event;Exposure to;extracellular vesicles;Extravasation;Fibrinogen;Functional disorder;HIV;HIV therapy;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;Impaired cognition;Impairment;Infection;Infiltration;Injury;innovation;knock-down;Lead;Link;Macaca mulatta;Maintenance;Measures;Mediating;Mesenchymal Stem Cells;Metabolic;Mitochondria;mitochondrial dysfunction;mouse model;Mus;Nervous System Disorder;neuroinflammation;Neurologic Dysfunctions;Neurons;Neuropathogenesis;Nitric Oxide;nonhuman primate;NOS3 gene;novel;Nutrient;Oxidative Stress;Pathogenicity;Patients;Persons;Phosphorylation;Plasma;Play;Predisposition;prevent;Production;Proteins;Publishing;Regimen;Regulation;Reporting;Research;Respiration;Role;Science;simian human immunodeficiency virus;Site;SIV;Testing;Therapeutic;therapeutically effective;Toxin;two photon microscopy;United States National Institutes of Health;uptake;vascular cognitive impairment and dementia;Vascular Endothelium;venule;vesicular release

PROJECT_TITLE: The effects of HIV-associated extracellular vesicles on mitochondrial dysfunction in brain microvessels


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative: Using a novel human intestinal explant model, this project aims to understand the mechanisms behind the loss of Type 3 innate lymphoid cells (ILC3) in People Living with HIV (PLWH) on antiretroviral therapy (ART) which is associated with decreased epithelial barrier integrity, increased microbial translocation and chronic immune activation. The ultimate goal is to shed light on the underlying mechanisms, including changes in the gut microbiome, behind ILC3 depletion and its effect on intestinal health to improve chronic immune activation in PLWH.

PI_NAMEs: NEFF, CHARLES PRESTON (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Address;Animal Model;antiretroviral therapy;Apoptosis;apoptosis in lymphoid cells;Automobile Driving;Bacteria;bacterial community;Behavior;Biological Assay;Biological Models;Cell Physiology;Cells;Characteristics;Chronic;comorbidity;Consensus;Data;Development;dysbiosis;Electrical Resistance;enteric pathogen;Environment;Epithelial Cells;Epithelium;experimental study;Exposure to;Feces;Flow Cytometry;fluorescein isothiocyanate dextran;Frequencies;gastrointestinal epithelium;Goals;Growth;gut microbiome;Health;High Prevalence;HIV;HIV Infections;Homeostasis;Human;IL17 gene;Immune;immune activation;improved;Individual;Induction of Apoptosis;Infection;Inflammation;Inflammatory;insight;interleukin-22;intestinal barrier;intestinal epithelium;Intestines;Knowledge;Link;Lymphoid Cell;Maintenance;Measurement;Mediating;men;Methods;microbial;microbial products;microbiome;Modeling;Mucous Membrane;neutralizing antibody;novel;novel therapeutic intervention;Persons;Phenotype;Predisposition;prevent;Process;Property;Resected;Role;sex;Stimulus;Streptococcus sanguis;Tissues;transcriptomics;Viral

PROJECT_TITLE: Effect of ILC3 loss on epithelial barrier function during ART Treated HIV infection


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Nanotechnology;Pediatric;Pediatric - AIDS;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE HIV treatment in pediatric patients is challenging and the treatment adherence is low due to factors such as lack of age-appropriate formulations, palatability issues of oral formulations, the daily reminder of HIV infection with oral therapy. This project will develop novel strategies to improve transdermal delivery of dolutegravir- rilpivirine combination for non-invasive and effective management of HIV infections in pediatric patients.

PI_NAMEs: DATE, ABHIJIT A (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: 12 year old;3-Dimensional;Adherence;Adolescent;Adult;Affect;Age;amphiphilicity;Anions;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;aqueous;behavioral economics;Biodistribution;Biological Availability;Brain;Cations;chemical stability;Child;Childhood;Clinical;Clinical Trials;Cold Chains;Country;crystallinity;Cutaneous Administration;Data;Development;Drug Combinations;Drug Kinetics;Effectiveness;Electrostatics;Enhancers;Evaluation;Excipients;Face;Formulation;Gel;Generations;Grant;health disparity;Health Personnel;health training;High Pressure Liquid Chromatography;HIV;HIV Infections;HIV therapy;human model;humanized mouse;Hydrophobicity;improved;In Vitro;in vivo;Incidence;infant infection;inhibitor;innovation;Integrase Inhibitors;Intramuscular;lipid solubility;Lipids;liquid formulation;Liquid substance;lymph nodes;melting;Membrane;method development;Methods;mouse model;Mus;nano;nanoemulsion;nanoformulation;Needlestick Injuries;non-nucleoside reverse transcriptase inhibitors;novel strategies;Oral;pediatric human immunodeficiency virus;pediatric human immunodeficiency virus infection;pediatric patients;Permeability;Pharmaceutical Preparations;pill;Plasma;Population;Preparation;prototype;psychosocial;Regimen;Research;Resource-limited setting;Reverse Transcriptase Inhibitors;Route;Salts;Self Administration;Skin;socioeconomics;Solubility;Suspensions;Technology;Temperature;Testing;Therapeutic;Thick;Tissues;treatment adherence;Vagina;Viral Physiology;water solubility

PROJECT_TITLE: Ionic liquid-based nanoemulsion containing combination antiretroviral drugs forthe transdermal treatment of pediatric HIV infection


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Neurosciences;Pediatric

ORG_CITY: DURHAM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: DUKE UNIVERSITY

PHR: Research Narrative Disorganization of orofacial rhythmic movements leads to severe behavioral consequences. For example, discoordination of swallowing and breathing produces choking, which is the fourth leading cause of unintentional death among preschool children and elderly and the leading cause of death among infants. This project aims to shed light on why these life-threatening symptoms occur in many forms neurological malfunctions by mapping and dissecting the brainstem circuits that control orofacial movements.

PI_NAMEs: LI, NUO  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Animals;Behavior;Behavioral;Biological Models;Brain;Brain Stem;Breathing;Cause of Death;cell type;Central Nervous System;central pattern generator;Cessation of life;Child;Choking;Data;Deglutition;density;Dissection;drinking;Elderly;Electrophysiology (science);Emerging Technologies;experience;Individual;Infant Mortality;Life;Maps;Mastication;Molecular;Motor;Motor Neurons;Movement;Mus;Muscle;Nerve Degeneration;neural;neural circuit;Neurologic;neurophysiology;neuroregulation;orofacial;Outcome;Output;Pattern;Perception;Periodicity;Preschool Child;programs;Psyche structure;Research;Symptoms;therapeutic development;Therapeutic Intervention;tool;vocalization

PROJECT_TITLE: Neural control of rhythmic orofacial movements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-J (70)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dental, Oral, and Craniofacial Disease;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Depression and anxiety are marked by differences in emotion processing that may originate in preschool emotional neurodevelopment. This project aims to characterize how early caregiving and negative affect influence preschool brain development, conferring risk for depression and anxiety symptoms. The candidate is well positioned to start their independent research program and have strong support from their department and broader university.

PI_NAMEs: CAMACHO, MARIA CATALINA (contact)

PROJECT_TERMS: Affect;Affective;Age;Anger;Anxiety;anxiety symptoms;Applications Grants;Arousal;Attention;Brain;career;Caregivers;caregiving;Categories;Child;child depression;Child Rearing;childhood anxiety;Cognitive;Collaborations;Complex;Computer Models;Cues;Data;Data Collection;Dedications;Depressed mood;depressive symptoms;Development;Distress;Dorsal;Emotional;Emotions;Endogenous Factors;Equipment;Etiology;experience;Faculty;Frequencies;Fright;Functional Magnetic Resonance Imaging;Funding;Future;gaze;Goals;Grant;high risk;Home;HRK gene;improved;Informal Social Control;innovation;Institution;Intervention;Lead;Leadership;Learning;Link;Measures;Mental Depression;Mentors;Mentorship;Methodology;Methods;Modeling;negative affect;neural;Neurobiology;neurodevelopment;neuroimaging;novel;Nursery Schools;Paper;Parents;Pattern;Positioning Attribute;professor;programs;Psychiatry;Psychological reinforcement;Reaction;Regulation;Research;Research Design;Research Personnel;Research Training;Resources;response;Risk;Risk Factors;Running;Sampling;scaffold;senior faculty;Services;Shapes;skills;support network;Technical Expertise;Testing;Training;Universities;University resources;Work;Writing

PROJECT_TITLE: A computational model for how risk for anxiety and depression influences affective neurodevelopment


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Alzheimer’s disease is one of the most common causes of dementia and a growing public health concern in the United States. Age is the greatest risk factor for AD, and dietary interventions that can promote health span and extend lifespan have significant potential to slow or prevent AD. This proposal will test the hypothesis that dietary interventions or pharmaceuticals which mimic the effects of these diets to reduce activity of the protein kinase mTORC1 and activate autophagy in the brain can slow or prevent the development and progression of AD.

PI_NAMEs: BABYGIRIJA, REJI  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Administrative Supplement;Affect;Age;Aging;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;American;Amino Acids;Animal Model;Animals;APP-PS1;Autophagocytosis;Biology of Aging;Brain;Branched-Chain Amino Acids;Caloric Restriction;Calories;career;Caring;Catabolism;Cause of Death;Cell Physiology;Chronic Disease;Cognition;Cognitive deficits;Complex;Consumption;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Dementia;Deposition;Development;Diet;dietary;dietary excess;Dietary Intervention;dietary restriction;Disease Progression;early onset;Eating;Economic Burden;effective therapy;Energy Intake;Essential Amino Acids;experimental study;extend lifespan;Faculty;Fasting;feeding;Fellowship;fly;Food;FRAP1 gene;geroprotector;Gliosis;Graduate Degree;Health;Healthcare Systems;healthspan;healthy aging;Hour;Human;human old age (65+);Impaired cognition;improved;Incidence;Individual;inhibition of autophagy;insight;interest;Intervention;Isoleucine;Keto Acids;laboratory experiment;Leucine;Life;life span;Link;Mediating;member;Mentorship;Metabolic;Metabolism;Modeling;Molecular;mouse model;multiple omics;Mus;Neurofibrillary Tangles;Nutrient;Oxidoreductase;Pathogenesis;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phosphotransferases;prevent;Protein Kinase;Protein-Restricted Diet;Proteins;Public Health;Regimen;Research;response;Risk Factors;Role;Signal Transduction;skills;small molecule inhibitor;Synapses;tau Proteins;tenure track;Testing;Training;United States;Valine;Wild Type Mouse;Work

PROJECT_TITLE: Administrative supplement for dependent care on "Dietary Interventions in Alzheimer's Disease"


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The the determinants fundamentally visualization to burden of HIV and socio-structural risk and protective factors that drive HIV re not evenly distributed in United States and disparities i n HIV-related outcomes persist. Characterizing t he socio-structural t hat drive racial and geography-related HIV disparities in at the local and county-levels is important to addressing the patterns of HIV burden. Our project informs an HIV data Web platform that can enhance multisectoral approaches to respond to HIV at the population level reduce HIV related disparities. a

PI_NAMEs: LUAN, HUI ;RANSOME, YUSUF  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;American;Area;Area Analyses;Automobile Driving;Bayesian Analysis;Big Data;Caring;Catchment Area;Categories;Church;Clinic;Communicable Diseases;Communities;community burden;community organizations;Community Surveys;contextual factors;County;cyber infrastructure;Data;data mining;Data Science;Data Sources;data visualization;data wrangling;density;Detection;Disease;Disease Outbreaks;Disparity;disparity reduction;Environment;Epidemic;Epidemiologist;ethnic disparity;Ethnic Origin;Event;experience;Facebook;geographic disparity;Geography;Goals;Health;health data;High Prevalence;HIV;HIV diagnosis;HIV disparities;HIV Infections;Human immunodeficiency virus test;Incidence;Individual;Infection;Institution;Intervention;Interview;Measurement;Measures;Mental Health;Methodology;Methods;Modeling;mortality;multiple data sources;novel;novel strategies;Outcome;Pattern;Persons;Policies;Population;pre-exposure prophylaxis;Prevalence;prevent;Privatization;protective factors;prototype;Provider;Proxy;Public Health;Race;racial disparity;Religion;Reporting;Research;Research Personnel;response;Risk Factors;Rural;Same-sex;Sampling;SARS-CoV-2 infection;screening;skills;social;social capital;social determinants;social health determinants;social structure;Socioeconomic Status;Source;Statistical Bias;Statistical Data Interpretation;Statistical Models;structural determinants;Structure;Surveillance Program;System;Technology;theories;Time;tool;Transportation;United States;United States National Institutes of Health;uptake;Validation;Visual;Visualization;web platform;web-based tool;willingness

PROJECT_TITLE: Leveraging Extensive Social Determinants Data and Spatial Data Science to Reduce HIV Incidence across the United States Ending the HIV Epidemic Counties


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative: Due to rising rates of resistance to traditional antibiotics, we are in critical need of novel types of approaches for combatting life-threatening bacterial infections. Here I propose a new direction for my lab that harnesses our newfound abilities to monitor gene expression in single bacteria, mammalian cells, and phages, as well as to manipulate host gene expression in a cell-type- specific manner. We will combine these new methods to understand bacterial pathogenesis and phage therapy dynamics at unprecedented single-cell resolution and to engineer new types of nontraditional phage therapies and host-directed antibiotics to combat the rising antibiotic resistance crisis.

PI_NAMEs: GITAI, ZEMER  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Autoimmune;Award;Bacteria;Bacterial Infections;Bacteriophages;cell type;Cells;combat;Defense Mechanisms;Development;Economic Factors;Engineering;experimental study;Funding Mechanisms;Gene Expression;Gene Expression Profiling;Immune system;immunoregulation;improved;In Vitro;in vivo;Infection;innovation;Intervention;Knowledge;Life;Listeria monocytogenes;Macrophage;Mammalian Cell;Marketing;Messenger RNA;Methods;Monitor;multidisciplinary;novel;novel antibiotic class;novel strategies;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Penicillins;Process;Reaction;Resistance;Resolution;response;science and society;sensor;single-cell RNA sequencing;Societies;success;System;Tail;Validation;virtual;War;Work

PROJECT_TITLE: A single-cell approach to developing non-traditional antibiotics


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed project will conduct a clinical trial that compares “business as usual” HIV testing in Department of Health clinics in South Africa to a novel intervention that aims to expand the reach of HIV testing and locate “hard-to-reach” undiagnosed cases of HIV by asking newly-diagnosed HIV-positive individuals to recruit their “expanded” social network members (i.e., friends and peers who are not necessarily direct risk partners) who they think might be at risk of being HIV-positive but undiagnosed to HIV testing, followed by referral to treatment or follow-up HIV testing services. The intervention's expanded social network recruitment will facilitate conversations between peers that will help to change norms around discussing HIV testing, increase HIV-related social support, and reduce HIV-related stigma among network members. These changes in stigma and support will in turn increase the likelihood that the members of these social networks will engage more in HIV testing and treatment services, ultimately leading to reduced HIV transmission and improved HIV health outcomes not only among individuals who had previously avoided engagement in testing and treatment, but also among the broader communities in which the intervention is implemented.

PI_NAMEs: WILLIAMS, LESLIE DENISE (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adoption;Africa South of the Sahara;arm;barrier to care;barrier to testing;Behavior;Businesses;care outcomes;Caring;Characteristics;Clinic;Clinical Trials;Communities;Counseling;design;Disparity;Education;Effectiveness;Epidemic;Evaluation;Event;Exclusion;experience;Family;Feeling;Female;follow-up;Friends;Future;gender disparity;Goals;Health;Health behavior;Health Promotion;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;implementation science;improved;improved outcome;Individual;Infection;Intervention;intervention participants;Interview;Link;male;member;men;Methods;Morbidity - disease rate;mortality;Newly Diagnosed;novel;Outcome;Participant;Patient Recruitments;peer;peer influence;Perception;Personal Satisfaction;Persons;Pilot Projects;Process;Qualitative Methods;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;recruit;Reporting;Research;Risk;Risk Behaviors;scale up;Services;Sex Behavior;Sexual Partners;Site;Social Network;social stigma;Social support;South Africa;staff intervention;standard of care;success;Testing;testing services;Time;transmission process;treatment services;trial comparing;Viral Load result;Woman

PROJECT_TITLE: Site-randomized Trial of a Novel Social Network Recruitment Intervention to Locate More Undiagnosed Positive Cases of HIV, Increase HIV Testing among Men, and Reduce HIV-related Stigma in South Africa


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: HANOVER

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE The first clinical efficacy trials of a broadly neutralizing antibody (bNAb) resulted in less benefit than expected and suggested that improvements are needed to prevent HIV infection. While considerable effort has focused on optimizing neutralization breadth and potency, it has been unclear what other strategies could also contribute to improving clinical efficacy. Two promising approaches to improve upon the protection afforded by bNAbs are to combine them and to improve their effector functions; defining the extent to which each of these strategies may increase antiviral activity in vivo will contribute to advancement of the most promising strategies to treat and prevent HIV infection.

PI_NAMEs: ACKERMAN, MARGARET E (contact);HESSELL, ANN JONES

PROGRAM_OFFICER_NAME: WARREN, JON T

PROJECT_TERMS: Affinity;Animal Model;Antibodies;antibody engineering;Antibody Therapy;Automobile Driving;Benchmarking;Clinical;clinical application;clinical efficacy;Complement;Data;design;Development;Disease;efficacy clinical trial;Engineering;Epitopes;Exhibits;Fc domain;Glycoproteins;Goals;HIV;HIV Infections;HIV-1;Human;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Infection prevention;infection risk;innovation;insight;Intervention;Knowledge;Modeling;Monitor;Monoclonal Antibodies;Mucous Membrane;Mutation;neutralizing antibody;next generation;nonhuman primate;Outcome;pathogen;Plasma;Population;pre-clinical research;pre-exposure prophylaxis;Predisposition;prevent;Prevention;prevention efficacy trial;Prophylactic treatment;simian human immunodeficiency virus;small molecule inhibitor;synergism;Systemic infection;Testing;Tissues;Translational Research;transmission process;Treatment Efficacy;Vaccine Design;vaccine development;Viral;Viral Antibodies;Viral Load result;Viral Physiology;Viral reservoir;Viremia;Virus;Work

PROJECT_TITLE: Mechanisms and means to improve HIV bnAb activity in vivo


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project narrative Patients with hypertrophic cardiomyopathy suffer from heart failure, abnormal heart rhythms, and shortened life spans. There are few current treatments that improve symptoms or change the trajectory of disease progression in these patients. This proposal will test the potential risks and benefits of a class of drugs called sodium-glucose cotransporter 2 inhibitors, proven effective for treatment of diabetes and other forms of heart failure, in patients with hypertrophic cardiomyopathy.

PI_NAMEs: DAY, SHARLENE M (contact)

PROGRAM_OFFICER_NAME: SHANBHAG, SUJATA MADHUKAR

PROJECT_TERMS: actigraphy;Adoption;Aftercare;Benefits and Risks;Bioenergetics;Biological Models;Blood Pressure;Butyrates;Cardiac;cardioprotection;Cardiovascular Diseases;cardiovascular effects;Cardiovascular system;Case Report Form;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Cross-Over Studies;Data;Diabetes Mellitus;diabetic;Disease;Disease Progression;Double-Blind Method;early phase clinical trial;early phase trial;Echocardiography;effective therapy;efficacy evaluation;EFRAC;Electronic Health Record;Eligibility Determination;Endocrinology;exercise capacity;experience;Fatty Acids;Functional disorder;Glucose;Goals;Health system;Heart;Heart Abnormalities;Heart Atrium;Heart failure;heart rhythm;hemodynamics;Hospitalization;Human;human model;human subject;Hypertrophic Cardiomyopathy;Hypoglycemic Agents;improved;Inherited;inhibitor;Institutional Review Boards;Ketone Bodies;Ketones;Ketosis;Left;Left Ventricular Outflow Obstruction;Life;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;manufacture;Measures;Metabolic;Monitor;mortality;Myocardial;Myosin ATPase;Non-Insulin-Dependent Diabetes Mellitus;Obstruction;off-label use;oxidation;Oxygen Consumption;Patients;Pediatric Hospitals;Pennsylvania;Pharmaceutical Preparations;Phase;phase II trial;Phosphocreatine;Physical Function;Placebos;Pre-Clinical Model;Preparation;preservation;pro-brain natriuretic peptide (1-76);Progressive Disease;Protocols documentation;Quality of Life Assessment;Radiology Specialty;Randomized;Registries;Reproducibility;Research Personnel;Safety;safety assessment;safety outcomes;saluretic;screening;Sodium;spectroscopic imaging;Stroke Volume;symporter;symptomatic improvement;Testing;Therapeutic;tool;Training;Treatment Efficacy;treatment response;Universities;Ventricular;Ventricular Arrhythmia

PROJECT_TITLE: SGLT-inhibitors in patients with hypertrophic cardiomyopathy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

PHR: Project Narrative The United States currently faces a public health epidemic of isolation and loneliness—with roughly half of U.S. adults reporting sometimes or always feeling lonely—but the neural and computational mechanisms that underlie forming and maintaining interpersonal relationships at the individual-level are still poorly understood, which will be crucial for generating new policies, programs, health care, and preventative measures. This proposal aims to characterize how and when computations along a cognitive hierarchy of social information processing (e.g., perception, learning, decision-making) impact social connection, and consequently, loneliness. Outcomes of this work will elucidate the interplay between mental health outcomes and computations underlying interpersonal relationships, which is critical for identifying risk factors of chronic loneliness and designing more personalized interventions to prevent future epidemics.

PI_NAMEs: RHOADS, SHAWN A (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Address;Adult;Affect;Anxiety;Award;Behavior;Behavioral;Behavioral Mechanisms;Belief;Brain;Cardiovascular Diseases;career;Cessation of life;Chronic;Cigarette;Clinical;Cognitive;cognitive process;Collaborations;Communication;Communities;Computer Models;Computer software;Computing Methodologies;craving;Cues;data-driven model;Death Rate;Decision Making;Dementia;Department chair;design;Diagnostic;Discipline;Distress;doctoral student;Economic Burden;Education;Educational process of instructing;Educational workshop;Epidemic;experience;Face;faculty mentor;Feeling;Fellowship;Foundations;Funding;future epidemic;Goals;Grant;hackathon;Healthcare;High Performance Computing;Human;Individual;Individual Differences;Inflammation;information processing;Infrastructure;innovation;Institution;instructor;Interpersonal Relations;Journals;Leadership;Learning;Loneliness;Magnetic Resonance Imaging;Malignant Neoplasms;medical schools;Mental Depression;Mental Health;Mentorship;Methodology;Methods;Motivation;multidisciplinary;Nature;neural;neuroimaging;neuromechanism;Neurons;Obesity;older adult;open source;Outcome;Paper;peer;Peer Review;Perception;personalized intervention;Phenotype;Policies;Positioning Attribute;posters;predictive modeling;premature;Premature Mortality;prevent;preventive intervention;Preventive measure;Printing;Process;professor;programs;Psychiatrist;Psychiatry;Psychologist;Psychopathology;Public Health;public health emergency;Publications;Reporting;Research;Resource Sharing;Risk;Risk Factors;Science;Scientist;Shapes;Smoking;social;social cognition;Social Hierarchy;Social isolation;social learning;Social Perception;Special Population;Stroke;Suicide;summer program;Support System;Surgeon;Symptoms;theories;Time;Training;undergraduate student;United Nations;United States;Universities;Vision;Work

PROJECT_TITLE: A hierarchical examination of the neural and computational mechanisms underlying loneliness


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Liver Disease

ORG_DEPT: PATHOLOGY

PHR: The proposed project will identify specific neutrophilic subpopulations with increased capacity to undergo NETosis that are expanded in HIV-1-infected individuals. Since functional dysregulation of the neutrophil population and its impact on the innate immune balance can be pharmacologically targeted, understanding the underlying pathogenic mechanisms will lead to novel treatment approaches in HIV-1 infection and other chronic inflammatory conditions.

PI_NAMEs: HEL, ZDENEK  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acceleration;Accounting;Acquired Immunodeficiency Syndrome;antiretroviral therapy;Arterial Fatty Streak;Atherosclerosis;atherothrombosis;Automobile Driving;Biological Assay;Blood;Cardiovascular system;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic;Chronic Disease;Consensus;cytokine;Data;design;Detection;Disease Progression;Endothelium;Equilibrium;extracellular;Gene Expression Profile;Genes;Goals;Gut Mucosa;HIV;HIV-1;Immune;immune activation;Individual;Infection;Inflammation;Inflammatory;Interferons;Intervention;Intestinal permeability;Invaded;Kupffer Cells;Leukocytes;Link;Liver;Liver diseases;Liver Fibrosis;Macrophage;Mediator;Methods;microbial;Morbidity - disease rate;mortality;NADPH Oxidase;neutrophil;Neutrophil Activation;novel;Organ;Pathogenesis;pathogenic microbe;pathogenic virus;Pathogenicity;Pathway interactions;Patients;Persons;pharmacologic;Phenotype;Plasma;Play;Population;Portal Hypertension;Process;Production;Prognostic Marker;Property;Publishing;Reactive Oxygen Species;recruit;Reporting;Research;response;Role;Sampling;scaffold;Sorting;Stimulus;success;Testing;Thrombus;Vascular Diseases

PROJECT_TITLE: Neutrophil subpopulations and NETosis in HIV-1 pathogenesis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Our awareness about the deleterious effects of intersectional stigma on entry into the HIV prevention continuum are at odds with the availability of viable solutions. Standardized patients (SP) provide a way to objectively measure intersectional stigma enacted in healthcare settings, and in so doing unlock novel strategies for intervening on its underlying causes. This research will evaluate a stigma intervention informed by SP observations to reduce barriers experienced by gay, bisexual, and other men who have sex with men, as well as people living with HIV in countries of low- and middle-income countries.

PI_NAMEs: SMITH, M KUMI (contact)

PROJECT_TERMS: Academic Detailing;acceptability and feasibility;Address;Advocate;AIDS prevention;Area;Awareness;Behavior;Bisexual;care seeking;Caring;China;Cities;Clinic;Clinic Visits;Clinical;Collaborations;Communities;community advisory board;Consent;Consolidated Framework for Implementation Research;Country;Data;design;Development;Discrimination;Disease;effective intervention;Evaluation;evidence base;Exercise;experience;Face;Failure;Feedback;Funding;Future;future implementation;Gays;Hawthorne Effect;Health;health care quality;health care settings;Health Services Accessibility;Healthcare;HIV;HIV risk;Homophobia;Hostility;Human immunodeficiency virus test;improved;Incidence;insight;Intervention;Interview;Knowledge;Lesbian Gay Bisexual Transgender;LGBT Health;low and middle-income countries;Measurement;Measures;Medical;Medical Education;men who have sex with men;Minnesota;non-verbal;North Carolina;novel strategies;Outcome;pandemic disease;Participant;Patient observation;Patient Self-Report;Patient-Centered Care;Patients;Perception;Persons;Policy Maker;Prevention;prevention service;Process;programs;Protocols documentation;Provider;provider behavior;public health relevance;Randomized;Randomized, Controlled Trials;Readiness;Records;Reporting;Research;Role;Running;rural health clinic;same sex behavior;Services;Sex Orientation;Sexuality;simulation;Site;social stigma;Source;Standardization;Stigmatization;success;Techniques;Testing;testing services;testing uptake;Time Study;tool;Training;treatment arm;United States National Institutes of Health;Universities;uptake;Visit;willingness

PROJECT_TITLE: Combating HIV Stigma in Healthcare Settings: A Standardized Patient Approach


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homicide and Legal Interventions;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: BALTIMORE

ORG_NAME: JUXTOPIA, LLC

ORG_STATE: MD

PHR: PROJECT NARRATIVE  The objective of the proposed NIH SBIR Phase I research and development (R&D) effort is to address the public health endemic of police murders against black males by improving police training with an innovative artificial intelligent (AI) enabled Juxtopia® CAMMRAD Police De-Escalate Virtual Reality e-training simulation. Specifically, the Juxtopia® AI police educator, “BES” (i.e., Ancient Egyptian God of Domestic Protection) will autonomously e-train and e-evaluate police trainees on culturally competent, ethical, and empathetic de-escalation skills using non-lethal force within a multi-user and interactive VR simulation; built upon the Juxtopia® Context-Aware Mobile Mixed Reality Assistive Device (CAMMRAD) VR software platform.

PI_NAMEs: DOSWELL, JAYFUS TUCKER (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: active shooter;Address;Adult;Affect;African American population;Agitation;American;animation;Artificial Intelligence;Awareness;Baltimore;Behavior;black men;Black Populations;Centers for Disease Control and Prevention (U.S.);Cessation of life;Cognitive;Color;Communities;Competence;Computer software;Consent;cost;cultural competence;Custom;Darkness;Data;Death Rate;Decision Making;deep learning algorithm;depressive symptoms;Domestic Violence;E-learning;Empathy;Empirical Research;Engineering;Environment;Ethics;Evaluation;experimental study;Funding;generative artificial intelligence;Gestures;Hand;health disparity;Health Policy;high risk;implicit bias;improved;Injury;innovation;Instruction;Intervention;Justice;Latino;Law Enforcement;Law Enforcement Officers;Learning;lifetime risk;man;Maryland;Measures;Mediating;Medical Care Costs;men;Methods;mixed reality;Motor Vehicles;multimodality;Murder;National Institute on Minority Health and Health Disparities;non-verbal;Performance;perpetrators;Persons;Phase;Police;prototype;psychological violence;Public Health;Publishing;Recommendation;Reporting;Research;research and development;Resistance;Risk;Self-Help Devices;simulation;skills;Small Business Innovation Research Grant;Software Engineering;Speech;Stress;System;Testing;Text;Training;Trauma;trauma symptom;United States;United States National Academy of Sciences;United States National Institutes of Health;verbal;Violence;virtual reality;virtual reality environment;virtual reality headset;virtual reality simulation;visual tracking;weapons;Woman;Work

PROJECT_TITLE: Culturally Competent, Ethical, and Empathetic AI Police E-Trainer for Improving Non-Lethal De-Escalation Skills in a Multi-User Virtual Reality Environment to Mitigate Murders Against Black Males.

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 JT (J1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

PHR: Project Narrative Radiation accidents at nuclear power plants or after the detonation of a nuclear weapon or radioactive bomb can result in delayed injury to the gastrointestinal tract, including tissue fibrosis. The overall goal of this project is to define novel mechanisms by which Type I interferon signaling impacts radiation-induced intestinal fibrosis in female vs. male mouse models and to build upon this knowledge to develop novel countermeasures against delayed tissue fibrosis from acute radiation exposure.

PI_NAMEs: LEE, CHANG-LUNG ;ROPER, JATIN  (contact)

PROGRAM_OFFICER_NAME: TALIAFERRO, LANYN P

PROJECT_TERMS: Ablation;Accidents;Acute;Animals;biological sex;Blocking Antibodies;Cardiac;Cells;Central Nervous System;Chronic;Clinical;Colon;Complication;Development;Distal;Dose;Double-Stranded RNA;efficacy evaluation;epithelium regeneration;Event;Exhibits;FDA approved;Female;Fibroblasts;Fibrosis;Future;gastrointestinal;Gastrointestinal tract structure;Genetic Transcription;Germ Lines;Goals;Hematopoietic;inhibitor;Injury;Interferon Activation;Interferon Type I;Interferons;intestinal epithelium;Intestinal Fibrosis;intestinal injury;Intestines;irradiation;JAK1 gene;Janus kinase;Knock-out;Knowledge;long-term sequelae;male;medical countermeasure;Mesenchymal;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;Mus;Nature;novel;Nuclear;Nuclear Power Plants;Nuclear Warfare;Nuclear Weapon;Organ;Pharmaceutical Preparations;Plants;Poly C;Poly I-C;Population;prevent;Prevention;Production;Publishing;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Fibrosis;Radiation Injuries;Radiation Toxicity;Radioactive;Rectum;response;sex;Sex Differences;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Intestines;Sorting;Standardization;stem cell population;Submucosa;Survivors;Testing;Tissues;type I interferon receptor;women versus men

PROJECT_TITLE: Sex differences in delayed development of gastrointestinal fibrosis after acute radiation exposure


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Rare Diseases;Sexually Transmitted Infections

ORG_STATE: NY

PHR: 8. Project Narrative The ANCHOR Correlative Science Supplement will conduct a cross-sectional HPV genotyping analysis to create a comprehensive profile of HPV type distribution in PLWH and identify optimal screening algorithms to identify those at risk of anal HSIL and cancer; analyze serial specimens from randomized participants to identify biomarkers of spontaneous HSIL regression to normal; process anal cancer and preceding HSIL biopsy specimens to create a foundation for future studies of molecular pathogenesis of progression from HSIL to cancer; and initiate exploratory tissue analyses preparatory to analyzing randomized cancer cases.

PI_NAMEs: SPARANO, JOSEPH A. (contact)

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: Address;Administrative Supplement;Adopted;AIDS Malignancy Consortium;Algorithms;Anus;arm;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker identification;Biopsy;Biopsy Specimen;cancer prevention;case control;Centers for Disease Control and Prevention (U.S.);Cervical;Clinical;Communities;Correlative Study;Cytology;Data;design;Development;Diagnosis;Disease;Ensure;Ethics;Exclusion;flexibility;Foundations;Future;Genomics;Genotype;Guidelines;High Prevalence;high risk population;HIV;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Incidence;Individual;Investigation;Laboratories;Laboratory Scientists;Lesion;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Medical;Mission;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;Multicenter Trials;novel therapeutic intervention;Oropharyngeal;Outcomes Research;Participant;Pathogenesis;Persons;Population;Positioning Attribute;premalignant;prevent;Prevention;preventive intervention;Process;progression marker;prospective;public health priorities;Randomized;Research;Research Personnel;research study;Resolution;Resources;Risk;Sampling;Science;screening;Secondary Prevention;Site;skills;Specimen;Squamous intraepithelial lesion;standard care;study population;System;Testing;Therapeutic Intervention;Time;Tissues;Training;treatment strategy;United States Preventative Services Task Force;Viral;Vision

PROJECT_TITLE: ANCHOR Correlative Science Administrative Supplement


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Racial and Ethnic Minority Health Research

ORG_CITY: SAN GABRIEL

ORG_NAME: 231 SHEEP LLC

ORG_STATE: CA

PHR: Project Narrative Glaucoma is the leading cause of irreversible blindness in the world and disproportionately impacts minorities, specifically Asian and Black African Americans. 231 Sheep is developing Ocuelar, a holistic solution consisting of a Smart EyeCup device, phone application, and database that aims to improve patient compliance with eye drops for the treatment of glaucoma. By preventing unnecessary vision loss, Ocuelar will disproportionately benefit Chinese and Korean Americans, thus creating more equitable health outcomes. 2

PI_NAMEs: LEE, SCOTT  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;adherence rate;African American population;age group;Asian;Asian Americans;Benchmarking;Black race;Blindness;Caring;Caucasians;Chinese;Chinese American;Clinical Data;Clinical Trials;Communities;community engagement;Computer software;cost;Data Display;Databases;Detection;Devices;Diagnostic tests;Disease;Disparity;Economics;Education;efficacy clinical trial;Elements;Ensure;Ethics;Eyedrops;Family;Family member;Feedback;follow-up;Fostering;Friends;Glaucoma;Health;health equity;Health Professional;Healthcare;Heart;improved;insight;Intervention Studies;Korean American;Koreans;Legal patent;Link;Measurement;Medical Care Team;medically underserved;medication compliance;medication nonadherence;Minority;minority communities;mobile application;Monitor;Motivation;Nanotechnology;non-compliance;Open-Angle Glaucoma;Operative Surgical Procedures;Optical Coherence Tomography;Outcome;Participant;Patient Compliance;Patient Monitoring;Patients;Pharmaceutical Preparations;Phase;Physiologic Intraocular Pressure;Play;Population;Prevalence;prevent;Randomized;remote health care;Research;retinal nerve fiber layer;Risk;Role;Savings;Scanning;Sheep;System;Telephone;Thick;Treatment Effectiveness;underserved community;Vision;Visual;welfare

PROJECT_TITLE: Ocuelar: Revolutionizing Glaucoma Management in Medically Underserved Communities