NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative This proposal focuses on the elastic protein titin, a recently revealed major player in the two types of heart failure, HFpEF and HFrEF. Using innovative approaches the proposed research addresses key gaps in our understanding of titin’s basic biology, the mechanistic basis of titin’s contribution to heart failure, and titin’s potential to function as a therapeutic target.

PI_NAMEs: GRANZIER, HENK L. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Address;Animal Model;Biology;Cardiac health;Cardiac Myosins;cardiac tissue engineering;Clinical;connectin;Dilated Cardiomyopathy;disease-causing mutation;drug candidate;Drug Screening;EFRAC;Elasticity;Elements;Excision;Exons;experience;Functional disorder;Genes;Goals;Heart;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart function;innovation;Location;Microfilaments;Molecular;Mutate;Mutation;myosin-binding protein C;novel;Patients;Phosphorylation;Post-Translational Protein Processing;posttranscriptional;preservation;Protein Isoforms;Proteins;Research;Resolution;RNA Splicing;Role;Sarcomeres;Scientist;Stress;Striated Muscles;Talents;Techniques;Testing;therapeutic target;Thick Filament;Time;Work

PROJECT_TITLE: Role of the giant protein titin in cardiac health and disease


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE DNA mutations drive the outgrowth of small populations of cells in normal tissue, years before clinical diagnosis of cancer. However, how such mutations change cellular behavior to provide them with a competitive growth advantage over adjacent cells remains poorly understood. To address this gap in knowledge, we propose to apply and develop novel single-cell sequencing technologies to study the mechanisms underlying growth advantage in normal tissues.

PI_NAMEs: LANDAU, DAN  (contact);SATIJA, RAHUL

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Admixture;Affect;Antibodies;ATAC-seq;Bar Codes;Biological Assay;Biology;cancer diagnosis;cell behavior;Cell Nucleus;Cell Physiology;Cell surface;cell type;Cells;Chromatin;clinical diagnosis;Clonal Expansion;Collaborations;Complementary DNA;Complex;Coupled;Data;Dependence;differential expression;DNA;DNA Sequence Alteration;driver mutation;Ensure;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;experience;fitness;Freezing;Gene Expression;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;Genomic DNA;genomic locus;Genomics;Genotype;Goals;Growth;Health;Hematopoiesis;histone modification;Histones;Human;Human body;human tissue;Hybrids;In Situ;Individual;Knowledge;Lead;Libraries;Link;Malignant Neoplasms;Maps;Measurement;Messenger RNA;Methods;methylome;Minority;Modification;Morphology;Mosaicism;mRNA Expression;multiple omics;mutant;Mutate;Mutation;nanobodies;Nature;Normal Range;Normal tissue morphology;novel;Oligonucleotides;Outcome;Phase;Phenotype;Population;programs;protein expression;Proteins;Recurrence;Resolution;Reverse Transcription;RNA;Sampling;Signal Transduction;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Somatic Mutation;Technology;technology development;Tissues;tool;transcription factor;transcriptome;transcriptomics;Transposase;Work

PROJECT_TITLE: Single-Cell Multi-omics to Link Clonal Mosaicism (CM) Genotypes with Chromatin, Epigenomic, Transcriptomic and Protein Phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative This proposal investigates the how asthma and allergies develop on children using a new, small volume blood collection device and a novel assay technology. Once complete, a new system will have been validated in pediatric subjects and ready for transition into clinical research.

PI_NAMEs: BEEBE, DAVID J (contact);KERR, SHEENA CATHERINE

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adoption;Allergic;Allergic Disease;assay development;Asthma;base;Biological;Biological Assay;Biological Markers;Birth;Blood;Blood flow;Blood specimen;Blood Volume;CD28 gene;CD3 Antigens;Cell Physiology;Cell Separation;Cells;Cellular Assay;cellular imaging;Cellular Metabolic Process;Chemotaxis;Child;Childhood;Clinical Research;cohort;Cohort Studies;Collection;cytokine;Cytolysis;Data;Development;Devices;Disease;Early identification;Environmental Exposure;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Equipment;experience;extracellular;Extrinsic asthma;Farm;Funding;Gene Expression;Gene Expression Profiling;genetic risk factor;Health;Heel;Heterogeneity;Hypersensitivity;Immune;immune function;Immune system;immunological status;Infant;innovation;Interleukin-13;Interleukin-4;Interleukin-5;Label;Life;magnetic beads;Measurement;Measures;Metabolic;metabolic imaging;Methods;microfluidic technology;Microfluidics;Microscopy;milliliter;miniaturize;Modeling;Molecular;multiple omics;multiplex assay;neutrophil;next generation sequencing;novel;Optics;P-Selectin;Pain;Painless;pediatric patients;Pediatric Research;Phagocytosis;Phenotype;Population;Population Density;Production;Reactive Oxygen Species;Reagent;response;Risk;RNA;Running;sample collection;Sampling;Specificity;Stromal Cell-Derived Factor 1;Surface;System;T cell differentiation;T-Lymphocyte;Technology;Testing;Time;United States National Institutes of Health;Validation;Venipunctures;Whole Blood;Wisconsin

PROJECT_TITLE: A multiplexed micro scale assay for real time analysis of pediatric immune cell function


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Infant Mortality;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE "Leaky gut" is the proximate cause of susceptibility to necrotizing enterocolitis (NEC), a life-threatening, gastrointestinal emergency affecting 7-10% of preterm infants with mortality as high as 30-50%. This proposal seeks to establish a stool-based immune profile that can identify “at-risk" preterm infants with hyperpermeable intestinal barrier prior to the onset of NEC. The results of this study would facilitate clinical evaluation of preventive and therapeutic measures aimed at improving intestinal maturation and reducing the burden of NEC complications.

PI_NAMEs: MA, BING  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Affect;Age;Antibiotics;Bacterial Translocation;Bifidobacterium;Biodiversity;Biological Assay;Biological Markers;chemokine;Classification;claudin 3;Clinical;Clinical Research;cohort;Cohort Studies;Computer Models;cytokine;Dependence;Detection;Development;Diagnosis;Diagnostic;diagnostic tool;diagnostic value;dysbiosis;Early Diagnosis;Early Intervention;effective therapy;Emergency Situation;Etiology;Feces;feeding;Future;gastrointestinal;Gestational Age;Goals;gut microbiome;gut microbiota;Health;high risk;Human Milk;Immune;Immune response;Immune Targeting;Immunity;Immunologic Markers;Impairment;improved;Incidence;Infant;Infant Development;Inflammation;Inflammatory;Injury;insight;Interleukin-10;intestinal barrier;intestinal fatty acid binding protein;intestinal maturation;Intestinal permeability;Intestines;Knowledge;Laboratories;Lactulose;Leaky Gut;Life;Measures;metagenome;metagenomic sequencing;Methods;microbiome;microbiota;milk intake;mortality;Mucous Membrane;Nature;Necrosis;Necrotizing Enterocolitis;Neonatal;neonatal care;neonatal health;neonate;Newborn Infant;novel;novel strategies;Onset of illness;Phenotype;Population;postnatal;predictive marker;Predisposition;Pregnancy;Premature Infant;preterm newborn;prevent;Prevention;Prevention strategy;Preventive;Proteins;rational design;Research;research clinical testing;Resources;Rhamnose;Risk;Risk Factors;Scheme;Screening procedure;Severity of illness;sex;stool sample;sugar;Surveys;Symptoms;Technology;Testing;Therapeutic;Time;tool;trefoil factor;tumor-immune system interactions;Urine;Weight Gain

PROJECT_TITLE: Mucosal immune biomarkers to detect neonatal leaky gut

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Biotechnology;Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Children who receive CAR-T cell therapy to cure their leukemia can develop life threatening neurological side effects. We will use neuroimaging and other markers to predict whether a child will develop these severe neurotoxicities and determine whether neurotoxicity-induced brain damage causes long term problems in cognition and behavior. The biomarkers that we will identify will guide future clinical trials of safe and effective treatments to prevent neurotoxicity and interventions to alleviate long term impairments.

PI_NAMEs: BANSAL, RAVI  (contact);BHOJWANI, DEEPA ;PETERSON, BRADLEY S

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Abate;Acute Lymphocytic Leukemia;Adoption;Adverse effects;adverse outcome;Antigen Targeting;Attention;B-Cell Acute Lymphoblastic Leukemia;Behavior;Behavior Therapy;Behavioral;behavioral outcome;Behavioral Symptoms;Biological Markers;Blood - brain barrier anatomy;Blood flow;Blood specimen;Brain;brain abnormalities;brain based;Brain imaging;Brain Injuries;brain magnetic resonance imaging;CAR T cell therapy;CD19 Antigens;CD19 gene;Cerebral Edema;Characteristics;Child;chimeric antigen receptor T cells;Clinical;Clinical assessments;Clinical Trials;Cognition;Cognitive;cognitive change;cognitive training;cytokine;Cytometry;Data;Delirium;density;Development;Diffuse;Dose;Dysphasia;Early identification;effective therapy;Encephalopathies;Endothelial Cells;Functional disorder;Future;Guidelines;high risk;imaging biomarker;Immune;immune effector cell-associated neurotoxicity syndrome;Immune response;Immune system;Immunologic Markers;Immunologic Monitoring;Immunophenotyping;Impaired cognition;Impairment;In complete remission;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;Infusion procedures;Intervention;leukemia;Leukemic Cell;Life;Long-Term Effects;long-term sequelae;Longitudinal cohort study;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mediating;Metabolic;Metabolism;Monitor;multimodality;Neurobehavioral Manifestations;Neurocognitive Deficit;neurocognitive test;neuroimaging;neuroimaging marker;Neurologic;Neurologic Symptoms;Neuronal Injury;Neurons;neuroprotection;Neuropsychological Tests;neurotoxicity;Neurotoxicity Syndromes;novel therapeutics;Outcome;Pathway interactions;Patients;peripheral blood;Pilot Projects;prediction algorithm;predictive marker;prevent;preventive intervention;Preventive treatment;Prior Chemotherapy;processing speed;Production;prospective;Publishing;Recommendation;Refractory;Relapse;Resolution;Risk;Serum;Severities;Short-Term Memory;side effect;small molecule inhibitor;Structure;Surrogate Markers;Symptoms;T-Cell Activation;Thinness;Time;white matter

PROJECT_TITLE: Brain-Imaging Markers of Neurotoxicity and Long-Term Outcomes after CAR-T Cell Therapy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE A major barrier in opioid addiction research is our limited understanding of the organization of the endogenous opioid response system in the brain. Our project will tackle this issue by systematically identifying opioid- responsive brain cell types in clinically relevant opioid use states (dependence, withdrawal, abstinence, pain management) using single cell transcriptomics technology in the entire brain, and circuit mapping and in vivo functional imaging studies in the prefrontal cortex. This study will generate an exceptional resource for the field to explain how opioids change the brain and to discover novel therapeutic approaches to prevent and treat opioid use disorders.

PI_NAMEs: SCHERRER, GREGORY  (contact);SCHNITZER, MARK J;ZENG, HONGKUI

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;addiction;Adenylate Cyclase;Amygdaloid structure;Anatomy;Architecture;Arrestins;Behavioral;Binding;Brain;brain cell;Brain imaging;BRAIN initiative;Brain region;Catalogs;cell type;Cells;Censuses;Chronic;clinically relevant;Complex;Computer Analysis;computer studies;conditioned place preference;cranium;Data;Data Coordinating Center;Data Set;Databases;Dependence;Dissection;dorsal raphe nucleus;Electrophysiology (science);endogenous opioids;Ensure;experimental group;Foundations;Functional Imaging;Funding;G-Protein-Coupled Receptors;Gene Expression;Gene Family;gene network;Genes;GTP-Binding Proteins;Habenula;Hippocampus;Hypothalamic structure;imaging modality;imaging study;Immunohistochemistry;improved;In Situ Hybridization;in vivo;innovation;innovative technologies;Ion Channel;Knowledge;Label;Length;Link;Maps;Mediating;midbrain central gray substance;Modeling;Molecular;molecular dynamics;molecular sequence database;Molecular Target;Morphine;mouse model;mu opioid receptors;Mus;National Institute of Drug Abuse;Nerve Tissue;Nervous System;neural;neural circuit;Neurobiology;Neurons;nociceptin;novel;novel therapeutic intervention;Nucleus Accumbens;Nucleus solitarius;Opiate Addiction;Opioid;Opioid Analgesics;opioid exposure;Opioid Peptide;Opioid Receptor;opioid use;opioid use disorder;Optics;ORL1 receptor;Output;Pain;Pain management;parabrachial nucleus;Pattern;Phosphotransferases;Postoperative Pain;preBotzinger complex;Prefrontal Cortex;prevent;Protein Isoforms;Protein Subunits;Protocols documentation;radioligand;receptor;Reporter;Research;Research Personnel;Resolution;Resources;response;Science;Self Administration;side effect;single nucleus RNA-sequencing;single-cell RNA sequencing;Slice;Specificity;Surveys;Synapses;System;Technology;Thalamic structure;Toxic effect;transcriptomics;Ventilatory Depression;Ventral Tegmental Area;Viral;Withdrawal;Work

PROJECT_TITLE: A comprehensive dissection of cell types, circuits and molecular adaptations during opioid use


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Narrative We propose to leverage a single-cell systems biology approach to dissect the cellular programs that are driving malignant brain tumors and reconstruct their history. We will characterize clinical samples by single-cell multi-omics modalities, perform advanced computational analyses and test regulators of cell state as novel therapeutics for these incurable malignancies.

PI_NAMEs: SUVA, MARIO LUCA (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Address;Automobile Driving;Biological Assay;Biology;cancer cell;Cancer Model;candidate validation;CDK4 gene;Cell Differentiation process;cell dimension;Cells;Chromatin;Clinical;Clonal Evolution;Computer Analysis;Computing Methodologies;Coupled;Data;data platform;Data Set;Development;Diffuse;Disease;DNA;DNA Methylation;driver mutation;effective therapy;Epidermal Growth Factor Receptor;Epigenetic Process;Evolution;experimental study;fitness;Gene Expression Profile;General Hospitals;Genetic;genetic information;Genetic Transcription;Genetic Variation;Genome;Genotype;Glioblastoma;Glioma;Grant;Growth;Hematologic Neoplasms;Heritability;Human;in vivo;Joints;Knock-out;Laboratories;Ligands;Link;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Massachusetts;MDM2 gene;Measures;Medicine;Methods;methylome;Modality;model organism;multimodality;multiple omics;mutant;Mutation;neoplastic cell;New York;novel;novel therapeutics;PDGFRA gene;Phenotype;Phylogenetic Analysis;PIK3CA gene;programs;receptor;Recording of previous events;Recurrence;Research Proposals;Resolution;Role;Sampling;sequencing platform;single cell sequencing;single-cell RNA sequencing;Somatic Mutation;Source;Specimen;stem cells;Systems Biology;Technology;Testing;therapy resistant;transcription factor;transcriptome;Trees;tumor;Variant

PROJECT_TITLE: Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative Alcohol-associated liver disease (ALD) remains a significant cause of liver-related morbidity and mortality in the United States and worldwide. The successful completion of the proposed study will lead to a better understanding of the role of ductular reaction in cholangiocytes and the SP/NK1R axis in the pathogenesis of ALD. This may lead to novel treatment paradigms for managing ALD through the pharmacological inhibition of the SP/NK1R axis.

PI_NAMEs: EKSER, BURCIN ;GLASER, SHANNON STROUD (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: 3-Dimensional;Address;Affect;Afferent Neurons;alcohol effect;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;antagonist;aprepitant;Attention;Biliary;Biological;Cell Aging;Cell Proliferation;cell type;Cells;chemotherapy;cholangiocyte;Cholestasis;Chronic;chronic liver disease;Cirrhosis;Country;Coupled;Critical Pathways;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;Disease Progression;Drug usage;Electronic Mail;Enzymes;Epithelial Cells;Ethanol;Fatty acid glycerol esters;Fatty Liver;FDA approved;feeding;Female;Fibrosis;Functional disorder;Genes;Goals;GTP-Binding Proteins;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human;immune activation;immune cell infiltrate;immunoreactivity;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;knock-down;Knockout Mice;Knowledge;Kupffer Cells;lipid biosynthesis;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;Macrophage;male;Measures;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Nausea and Vomiting;neuroendocrine phenotype;neuroinflammation;Neuropeptides;neutrophil;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;Organoids;Outcome;paracrine;Pathogenesis;Pathology;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;pharmacologic;Phenotype;Play;PPAR gamma;prevent;Primary carcinoma of the liver cells;Proliferating;Reaction;receptor;receptor expression;Receptor Signaling;recruit;Regulation;Repression;response;Role;Sampling;senescence;Serum;sex as a biological variable;Signal Transduction;simple steatosis;SIRT1 gene;Steatohepatitis;Substance P;System;Tachykinin;TACR1 gene;Testing;Therapeutic;Tissues;United States;Up-Regulation;Work

PROJECT_TITLE: Regulation of Ductular Reaction by Substance P during Alcohol-induced Liver Injury

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: AMHERST

ORG_DEPT: DENTISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE There remains in the United States a critical need for well-trained investigators in dental, oral and craniofacial research. This institutional career development application supports the Buffalo Oral-Research and Specialty Training Program (BORST) Program, an integrated program based in the School of Dental Medicine at the University at Buffalo to help train the next generation of dental specialist-scientists engaged in dental, oral and craniofacial research. Career development opportunities will include clinical dental specialty training disciplines of periodontics, orthodontics and oral pathology combined with integrated graduate research areas of immunology/innate defenses, relationship of oral pathogens to systemic disease, saliva and salivary glands, microbiome, and bone and connective tissues/tissue engineering.

PI_NAMEs: KIRKWOOD, KEITH L (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Area;Award;Biology;Biomedical Engineering;Bone Tissue;career;career development;Clinical;Connective Tissue;craniofacial;Dental;Dental Schools;Dentists;Discipline;Doctor of Philosophy;Educational Curriculum;Evaluation;experience;Faculty;Fostering;Goals;Grant;Health;Immunology;Institution;Interdisciplinary Study;Measures;medical schools;medical specialties;Medicine;Mentored Clinical Scientist Development Program;Mentors;microbial;Odontogenesis;Oral;oral biology;Oral health;oral pathogen;Organism;Pathogenesis;Postdoctoral Fellow;Productivity;Program Development;Request for Applications;Research;Research Training;Saliva;Salivary Glands;Science;Scientific Advances and Accomplishments;Scientist;Specialist;Support System;Systemic disease;Talents;Testing;Time;Tissue Engineering;Training;training opportunity;Training Programs;Universities


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Over 40% of the U.S. population is struggling with obesity, which contributes to type 2 diabetes, cardiovascular disease, and cancer. The goal of our work is to provide evidence-based, targeted approaches for the treatment and prevention of obesity by understanding alterations in glutamate systems involved in reward and motivation.

PI_NAMEs: FERRARIO, CARRIE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adult;adult obesity;Affect;Alzheimer's Disease;Amygdaloid structure;Behavior;Behavioral;Behavioral Mechanisms;Blinking;Brain;brain behavior;Breeding;Cardiovascular Diseases;cardiovascular disorder risk;cell type;Cells;Clinical;Cognitive;Communities;Consumption;Corpus striatum structure;craving;Cues;Data;Development;Diet;Eating;evidence base;Excision;Exposure to;Female;Food;food consumption;food craving;Foundations;Functional Magnetic Resonance Imaging;Future;Glutamate Receptor;Glutamates;Goals;Health;Human;insight;Link;male;Malignant Neoplasms;Measures;Medial;Mediating;Metabolic;Metabolic dysfunction;Modeling;motivated behavior;Motivation;National Institute of Diabetes and Digestive and Kidney Diseases;neural;neurobehavioral;Neurobiology;Neurons;Neurophysiology - biologic function;Neurosciences;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Nucleus Accumbens;obese person;Obesity;Obesity Epidemic;obesity prevention;optogenetics;patch clamp;Permeability;Persons;pharmacologic;Physiology;Play;Population;pre-clinical;Pre-Clinical Model;Predisposition;Prefrontal Cortex;prevent;preventable death;Prevention strategy;Process;programs;Rat Transgene;Rattus;Reporting;Research;Resistance;response;Rewards;Role;sex;Signal Transduction;Slice;Smell Perception;Source;Specificity;Strategic Planning;Synaptic Transmission;System;Testing;therapy development;tool;Transgenic Organisms;transmission process;treatment strategy;United States National Institutes of Health;Weight;Weight Gain;Women's study;Work

PROJECT_TITLE: Striatal glutamatergic plasticity and junk-food induced enhancements in cue-triggered food-craving

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Alzheimer’s disease (AD) is the most common cause of dementia (a progressive loss of thinking and memory skills) in older adults, and the most common inherited genetic risk factor is the APOE4 allele. However, it is unclear how and why APOE4 increases AD risk. In this project, we will evaluate the role of APOE4-related alterations in the complement pathway within human spinal fluid as a potential cause of increased AD risk, the relationship between complement pathway activation and cognitive decline 7.5 years later, and the effect of modulating APOE protein function/biology on the complement pathway in the brain.

PI_NAMEs: BERGER, MILES ;PRIVRATSKY, JAMIE R (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta deposition;Adult;Age;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Appearance;Autopsy;Bacteria;Bathing;Biological Assay;Biological Markers;Biology;Brain;Brain Injuries;Caring;Cells;Cerebrospinal Fluid;Chemicals;Classical Complement Pathway;Code;Cognition;Cognitive;cohort;Complement;Complement 1q;Complement Activation;Complement Inactivators;complement pathway;Data;Dementia;Deposition;Development;Disease;Disease Resistance;DNA;Drug Targeting;Eating;Elderly;Encephalitis;Enrollment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Frequencies;Gender;Genetic;Genetic Carriers;genetic risk factor;genetic variant;Hereditary Disease;Human;Hybrids;Immune;Impaired cognition;In Vitro;in vivo;Inherited;insight;Late Onset Alzheimer Disease;Lead;Life;life span;Life Style;Liquid substance;Measures;Memory;Methods;mimetics;Molecular;Mus;Nervous System Disorder;Neurites;Neurofibrillary Tangles;Neurons;novel;older adult;Operative Surgical Procedures;Outcome;Pathology;Pathway interactions;Patients;peptidomimetics;Peripheral;Persons;Pharmaceutical Preparations;Phase II Clinical Trials;postoperative delirium;Postoperative Period;prevent;Process;protein function;Proteins;Proteomics;Regulation;Risk;Role;Sampling;Senile Plaques;Set protein;sex;Signal Transduction;skills;Spinal Cord;Spinal Puncture;Synapses;tau Proteins;tau-1;Testing;Thinking;trait;Work

PROJECT_TITLE: APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Tumor and microenvironment cells often interact to promote cancer progression, but gaps remain in our understanding of how these interactions occur. My recent publication uncovered a novel cilia-enriched “interface” cell state adopted by both tumor and microenvironment cells in melanoma, indicating that the interface may have a critical role in melanoma progression. My proposed work will investigate how the interface is established and how it contributes to invasion, and could provide novel therapeutic targets to prevent melanoma progression.

PI_NAMEs: HUNTER, MIRANDA VICTORIA (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Adipocytes;Adopted;Advisory Committees;arm;Basic Cancer Research;Biological Models;Cancer Biology;Cancer Center;cancer genetics;career;career networking;cell behavior;Cell Communication;cell type;Cells;Chromatin;Chromatin Remodeling Factor;Cilia;Cleavage Under Targets and Release Using Nuclease;clinically relevant;combat;Complement;Coupled;Data;Doctor of Philosophy;Embryo;Ensure;Environment;Epidermis;Epigenetic Process;experimental study;Family;Fibroblasts;follow-up;Gene Expression;Genes;Genetic;Goals;Growth;Hallmark Cell;HMGB2 gene;Human;Human Cell Line;human disease;Imaging Device;Immune;Immunotherapy;improved;In Vitro;in vivo;Individual;Invaded;Laboratories;Lead;Mediating;Melanoma;member;Memorial Sloan-Kettering Cancer Center;Mentors;Metastatic Melanoma;Microscopy;Modeling;Molecular;neoplastic cell;new therapeutic target;notch protein;novel;novel therapeutics;Phase;Postdoctoral Fellow;prevent;programs;Proliferating;Publications;Recording of previous events;Research;Role;SHH gene;Signal Transduction;single-cell RNA sequencing;Skin;spatial integration;success;Survival Rate;System;targeted treatment;Technical Expertise;therapeutic target;three dimensional cell culture;Tissues;transcription factor;transcriptional reprogramming;transcriptomics;Transforming Growth Factor beta;translational cancer research;tumor;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Up-Regulation;Work;wound healing;Zebrafish

PROJECT_TITLE: The role of the novel interface cell state in melanoma invasion

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Prevention;Pulmonary Fibrosis;Pulmonary Hypertension;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because discovery of the role of ADAM17 activity on circulat- ing myeloid-derived suppressor cells will increase understanding of immunologic contribution to pathogenesis of pulmonary vascular remodeling, and thus pulmonary hypertension. The project is relevant to the NIH’s mission because knowledge of the mechanism underlying pulmonary hypertension associated with chronic lung disease will help to reduce the disease burden on a patient population that is currently without any available therapeutic options.

PI_NAMEs: BRYANT, ANDREW JUSTIN (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Alleles;Animal Disease Models;Attenuated;biobank;biomarker identification;Bleomycin;Blood specimen;burden of illness;candidate marker;Cell Separation;Cells;chemokine receptor;Chronic;Chronic lung disease;Clinic;Clinical;Cytoprotection;Data;defined contribution;Development;Diagnosis;Discrimination;Disease;disease model;disorder control;disorder prevention;Enrollment;experimental study;Functional disorder;Goals;granulocyte;grasp;Hypoxia;idiopathic pulmonary fibrosis;IL8RB gene;Immune;Immunologics;immunoregulation;Immunotherapeutic agent;improved;Infection;Inflammatory Response;inhibitor;Injury;innovation;Interleukin-8B Receptor;Interstitial Lung Diseases;Intervention;Knowledge;Leukocytes;Ligands;Lung;lung vascular inflammation;Malignant Neoplasms;Mediating;Mediator;Metalloproteases;Mission;Modeling;Molecular;monocyte;Morphology;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasms;neoplastic cell;neutrophil;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient population;Patients;Peptide Hydrolases;peripheral blood;Phenotype;Pilot Projects;Population;Prevention;Probability;profiles in patients;Prognosis;prognostication;Proliferating;prospective;Public Health;pulmonary arterial hypertension;Pulmonary Fibrosis;Pulmonary Hypertension;pulmonary vascular disorder;pulmonary vascular remodeling;recruit;Research;Role;Secondary to;Severity of illness;Signal Transduction;targeted treatment;Testing;Therapeutic;TIMP3 gene;Tissue-Specific Gene Expression;Tissues;TNF-alpha converting enzyme;trafficking;Transgenic Mice;translatable strategy;translational impact;United States National Institutes of Health;Vascular remodeling;Vasodilator Agents;Whole Blood

PROJECT_TITLE: Role of ADAM17 in MDSC-Mediated Development of Pulmonary Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Lay Narrative The overarching goal of this proposal is to identify CVH trajectories from birth through age 20 among a diverse cohort of 7,000 children, to determine risk factors and assets associated with these childhood CVH trajectories and develop a novel CVH growth curve for use in clinical practice.

PI_NAMEs: ALLEN, NORRINA BAI (contact)

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: Acceleration;Address;Adolescence;Adult;Age;Age Years;Behavior;Behavior assessment;Behavioral;Birth;Blood Pressure;Body mass index;burden of chronic illness;burden of illness;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Chicago;Child;Childhood;Cholesterol;Cities;Clinical;clinical care;clinical phenotype;clinical practice;cohort;contextual factors;critical period;Data;Data Collection;Dementia;Development;Diabetes Mellitus;Diet;disorder risk;Disparity;Dyslipidemias;early childhood;Electronic Health Record;electronic health record system;Enrollment;Environment;epidemiology study;Ethnic Origin;Family;Family health status;follow-up;Future;Generations;Glucose;Goals;Grant;Growth;Guide prevention;Health;Health Status;healthspan;high risk;Hypertension;Incidence;Individual;infancy;innovation;interest;Intervention;Life;Life Cycle Stages;life span;Life Style;lifestyle data;Link;Longitudinal Studies;Malignant Neoplasms;Measurement;Measures;Mental Depression;National Heart, Lung, and Blood Institute;Neighborhoods;Neuropsychology;novel;Obesity;obesity in children;Outcome;Parents;Participant;Physical activity;Population;preservation;Prevalence;prevent;Prevention;Prevention strategy;Questionnaires;Race;rate of change;Recording of previous events;recruit;Research Design;resilience biomarker;resilience factor;Resources;Risk Factors;skills;Smoking;Social Environment;Social support;Socioeconomic Status;stem;Surveys;Technology;Time;tool;Translating;young adult;Youth

PROJECT_TITLE: Cardiovascular Health Trajectories from Birth Thru Adolescence in A Diverse Cohort of Children

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Schizophrenia;Serious Mental Illness

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: The single-base-pair resolution maps of DNA (hydroxy)methylation will be generated in sorted inhibitory and excitatory neurons at key time points of postnatal brain development and adulthood, as well as in the brains of psychiatrically normal individuals and patients with schizophrenia and bipolar disorder. The data will be integrated with genetic findings for these disorders as well as with other omics data that have been generated by the PsychEncode Consortium. We anticipate that this work will reveal the molecular and cellular mechanisms and causal relationships of genetic associations, and will suggest specific subtypes of neurons that contribute to disease risk.

PI_NAMEs: LIU, CHUNYU  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Aberrant DNA Methylation;Adolescence;Adult;Affect;Alleles;Attention;Autopsy;base;Base Pairing;Binding Sites;Bipolar Disorder;bisulfite sequencing;Brain;brain cell;Brain region;case control;Cell Nucleus;cell type;Cells;Childhood;Chromosome Mapping;Data;Data Set;demethylation;Development;Disease;disorder risk;DNA;DNA mapping;DNA Methylation;Enhancers;Epigenetic Process;epigenome;epigenomics;Etiology;excitatory neuron;Fluorescence;Functional disorder;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Risk;Genetic Transcription;genetic variant;Genome;genome wide association study;Glutamates;histone modification;Human;Individual;inhibitory neuron;insertion/deletion mutation;Interneurons;Link;Maps;Measures;Mediating;Mental disorders;Methods;Methylation;methylome;Minor Lymphocyte Stimulatory Loci;Modification;Molecular;neural;Neuroglia;Neurons;neuropsychiatric disorder;Nuclear;Nucleic Acid Regulatory Sequences;Nucleotides;Patients;Population;postmitotic;postnatal;postnatal development;Prefrontal Cortex;Process;progenitor;promoter;Quantitative Trait Loci;recruit;Regulatory Element;Reporting;Resolution;risk variant;Role;Sampling;Schizophrenia;sex;Sex Bias;Site;Sorting;spatiotemporal;Specimen;Techniques;Testing;Time;Tissue Differentiation;Tissues;transcription factor;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Work

PROJECT_TITLE: 1/3 High-resolution mapping of cell type-specific DNA (hydroxy)methylation in the human brain during postnatal development and in psychiatric disease.


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases;Microbiome;Nutrition;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Project Narrative Here we hypothesize that the gut microbiota, the metabolites it produces and their effects on immune function play a key role in determining the outcome of surgical injury and infection. In this proposal we seek to elucidate the mechanisms by which key gut microbiota-derived metabolites (butyrate, tryptophan derivatives, etc) program macrophages to express a survival-related phenotype leading to full recovery. The final goal of this proposal is to develop and test a de novo assembled microbial consortia based on the data generated that will enhance macrophage function and improve survival in mice subjected to surgical injury and infection.

PI_NAMEs: ALVERDY, JOHN C (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Adverse effects;anti-cancer research;Antibiotic Resistance;Antibiotics;Back;Binding;Bone Marrow;Butyrates;Cancer Biology;Cecum;clinically relevant;Coculture Techniques;Communicable Diseases;Consumption;Coupling;Critical Illness;Data;Doctor of Philosophy;Exposure to;Family;Feces;Funding;Gene Expression;global health;Goals;gut microbiome;gut microbiota;Health;Hepatectomy;Histones;Human;immune function;Immunology;Impairment;improved;in vivo;Indoles;Infection;Inflammation;Injury;Laboratories;Libraries;Link;Macrophage;Metabolism;microbial;microbiome;microbiome alteration;microbiome research;microbiota;microbiota metabolites;mid-career faculty;Modeling;Molecular;Molecular Conformation;mortality;mouse model;Mus;nutrition;Operative Surgical Procedures;Pancreatitis;pathogen;Pathogenicity;Patients;Pattern;Peritoneum;Peritonitis;Phenotype;Play;postoperative recovery;pressure;Process;Production;professor;programs;Recovery;Resistance;Resolution;restoration;Role;Serratia marcescens;Stress;Structure;surgery outcome;Surgical Injuries;Surgical Models;Testing;Therapeutic;Time;Tryptophan;Virulence;Virulent;western diet;Work

PROJECT_TITLE: Gut pathogen virulence and its therapeutic modulation during surgical injury


ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: While recombinant AAV vectors show promise in the clinic, limitations in the technology remain. The goal of this project is to create and isolate laboratory generated chimeric AAV vectors that have substantially enhanced ability to provide therapeutic DNA into the human liver, cross the human blood brain barrier to enhance CNS gene transfer, and improve the efficacy of genome engineering in human hematopoietic stem cells. The appropriate candidate vectors will be validated in humanized animal models and/or non-human primates as a step towards their use in human trials.

PI_NAMEs: KAY, MARK A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Address;adeno-associated viral vector;Amino Acid Sequence;Animal Model;Animals;Astrocytes;Back;Behavior;Blood - brain barrier anatomy;blood-brain barrier penetration;Capsid;Capsid Proteins;cell type;Cells;Chromatin;Clinic;Clinical Trials;clinically relevant;Complex;Cultured Cells;design;Disease;DNA;DNA Sequence;embryonic stem cell;Engineering;Factor IX;Family suidae;Funding;gene therapy;Gene Transfer;Genetic Diseases;Genome;genome editing;Genome engineering;Goals;Hematopoietic stem cells;Hemophilia B;Hepatocyte;high throughput screening;high throughput technology;Human;human disease;human induced pluripotent stem cells;human model;human tissue;humanized mouse;Humoral Immunities;Immune System Diseases;improved;In Vitro;in vivo;Infection;Integration Host Factors;knockout gene;Laboratories;Learning;Left;Libraries;Liver;Mammals;Measures;Mediating;Modeling;Molecular;mouse model;Mus;Mutagens;Nerve Degeneration;Neurons;neutralizing antibody;new technology;nonhuman primate;novel;Organoids;Penetration;Peptides;Plasma;Preclinical Testing;Primates;Property;Prophylactic treatment;Recombinant adeno-associated virus (rAAV);Recombinants;Rodent;Scheme;screening;Serum;stem;stem cell genes;success;System;Techniques;Technology;Testing;therapeutic DNA;Time;transduction efficiency;Transgenic Organisms;Translating;Variant;vector;Viral;Viral Genome;Virus;Work

PROJECT_TITLE: AAV capsid engineering for enhancing gene transfer

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE / RELEVANCE Contamination and fouling of surfaces by bacteria is a critical problem in many healthcare settings and can lead to serious and substantial burdens that are costly in economic and human terms. Many materials have been designed to resist bacterial fouling, but all of these strategies ultimately fail when deployed in real-world scenarios or for extended periods. Fundamentally new approaches to the design of robust antifouling surfaces and coatings that move beyond conventional materials design strategies are desperately needed, would have substantial impacts on human health, and are the focus of this project.

PI_NAMEs: LYNN, DAVID M (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TITLE: Slippery Nanoemulsion-Infused Polymer Coatings that Prevent Bacterial Fouling and Block Bacterial Virulence

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Clinical Research;Social Determinants of Health

ORG_CITY: FULLERTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: PROJECT NARRATIVE There is a shortage of researchers from diverse backgrounds in Medicine, Science, Technology, Engineering, and Mathematics (MSTEM) who devote their careers to issues that affect an aging population. The MSTEM Scholars Trained in Aging Research (MSTEM STAR) program at California State University, Fullerton (CSUF) aims to address this shortage through the implementation of a multidimensional aging science program. Students enrolled in the MSTEM STAR program will complete structured research experiences, an aging- science curriculum, and support and engagement activities, which will prepare them to pursue advanced degrees in MSTEM fields related to aging.

PI_NAMEs: PIAZZA, JENNIFER  (contact);ZETTEL-WATSON, LAURA

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Achievement;Address;Affect;Aging;aging population;aging related;Award;Bachelor's Degree;California;career;cohort;Communities;Complement;Critical Thinking;Data;Data Analyses;Dedications;Degree program;design;Dimensions;Disabled Persons;disadvantaged background;Discipline;Education;education research;Educational Curriculum;Educational Status;Enrollment;Environment;ethnic minority;Ethnic Origin;evidence base;experience;Faculty;faculty research;First Generation College Students;Fostering;Foundations;Future;Goals;Graduate Education;graduate school;Grant;Hispanic-serving Institution;Home;improved;Individual;Infrastructure;innovation;Institution;instructor;interest;Laboratory Research;Lesbian Gay Bisexual Transgender Queer;Life;Low income;Mentors;Minor;older adult;Population;Problem Solving;Process;Program Evaluation;programs;Race;Readiness;recruit;Research;research data dissemination;Research Methodology;Research Personnel;Research Training;Science;science, technology, engineering, mathematics, and medicine;Self Efficacy;Series;skills;Social support;socioeconomics;STEM field;Stream;Structure;Student recruitment;Students;success;summer research;symposium;Training;undergraduate student;Underrepresented Students;United States;Universities;Woman;Work

PROJECT_TITLE: A Multidimensional Aging Science Program: MSTEM Scholars Trained in Aging Research (MSTEM STAR)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Neurosciences;Nutrition;Obesity

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it aims to address neurobiological mechanisms to understanding how palatable food overconsumption is facilitated after abstinence from such foods at brain circuit levels. Our objective is to identify neural circuit pathways driving the relapse to palatable food overconsumption by characterizing the leptin-responsive circuit that connects the lateral hypothalamus to the brain stem. We also propose to examine how leptin sensitivity in this circuit is changed by palatable food consumption and how circuit- specific leptin sensitivity can have effects on eating and body weight, thereby contributing to provide insight into targeted therapies for eating disorder and obesity patients.

PI_NAMEs: SHIN, SORA  (contact)

PROJECT_TERMS: Abstinence;Address;Adipose tissue;Anorexia;anorexic;Automobile Driving;Body Weight;Brain;Brain Stem;Consumption;Data;Desire for food;Diet;Down-Regulation;Eating;Eating Disorders;Exposure to;Food;food consumption;Genetic;High Fat Diet;Hormones;Hyperphagia;Hypothalamic structure;Impairment;in vivo;in vivo monitoring;Individual;innovation;insight;Intake;interdisciplinary approach;knock-down;Knowledge;Lateral;Leptin;leptin receptor;Life Style;Medial;Mediating;Methods;midbrain central gray substance;Middle Hypothalamus;Modernization;Molecular;Molecular Profiling;Mus;neural;neural circuit;neuroadaptation;neurobiological mechanism;neuromechanism;Neuronal Dysfunction;Neurons;obese patients;Obesity;obesity treatment;Pathologic;Pathway interactions;Phosphorylation;preference;Preoptic Areas;Prevalence;Process;Public Health;receptor;Receptor Activation;receptor expression;Receptor Signaling;Relapse;Research;response;Risk Factors;Role;Schedule;Signal Transduction Pathway;STAT3 gene;success;Symptoms;targeted treatment;Testing;Therapeutic;Time;Tissues;Weight Gain;Withdrawal;Work

PROJECT_TITLE: A leptin-responsive lateral hypothalamus to ventrolateral periaqueductal gray circuit for palatable food overconsumption

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Our goal is to develop inhibitors of Giardia lamblia methionyl-tRNA synthetase as potential drugs for effective shorter-course treatment of symptomatic and asymptomatic giardiasis. We will use innovative techniques to profile and optimize the pharmacokinetic/pharmacodynamic relationships and chemical properties of functional groups to deliver at least one safe pre-clinical and 1-2 backup compounds for efficient treatment of clinical giardiasis.

PI_NAMEs: OJO, KAYODE K (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Address;alternative treatment;Ames Assay;analog;Biological Assay;Biological Availability;candidate selection;Cell Culture Techniques;Cells;chemical property;chemical synthesis;Chemicals;chemotherapy;Child;Chronic;Chronic diarrhea;chronic infection;Clinical;Clinical Treatment;cognitive function;Complementary therapies;cost;Cyst;cytotoxicity;Data;design;Development;Diarrhea;Disease;Dose;drug efficacy;Drug Kinetics;effective therapy;efficacy evaluation;efficacy study;efficacy testing;Engineering;enzyme activity;Enzymes;experimental study;Feedback;functional group;gastrointestinal;Gastrointestinal tract structure;Giardia;Giardia lamblia;Giardiasis;Goals;Growth;Health Benefit;HepG2;Human;imaging modality;Immunocompromised Host;improved;In Vitro;in vivo;in vivo imaging system;Incidence;indexing;Infant Mortality;Infection;inhibitor;innovation;Intestines;Ion Channel;Lead;lead optimization;Libraries;Liquid substance;Luciferases;Malabsorption Syndromes;Mammalian Cell;Measures;meetings;Metabolism;meter;Methionine-tRNA Ligase;Metronidazole;Metronidazole resistance;Micronucleus Tests;Microsomes;Mitochondria;Modeling;Molecular Mechanisms of Action;Monitor;mouse model;Mutagenesis;nanoluciferase;novel;novel therapeutics;Oral;Order Coleoptera;Parasites;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;pre-clinical;prevent;Property;Protein Biosynthesis;Proteins;Public Health;Rattus;receptor;Reporter;Research Proposals;residence;Resistance;Resource-limited setting;response;Rodent Model;Safety;scaffold;scale up;screening;Series;Signal Transduction;Stomach;Structure;symptom treatment;Symptoms;System;Techniques;Testing;Therapeutic;Time;tomography;Toxic effect;Toxicology;treatment duration;Trypanosoma brucei brucei;Work

PROJECT_TITLE: Methionyl-tRNA Synthetase inhibitors can be developed as novel Giardiasis therapeutics

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Tuberculosis is now the world's leading infectious cause of death; a more effective new vaccine is needed to stem this global health crisis. In order to rationally develop a new vaccine, more information is needed about the ways that certain Mycobacterium tuberculosis antigens elicit varying CD4 T cell functions at the site of infection. With studies of antigen specific CD4 T cells in the mouse model, and from the site of infection in human subjects with HIV-associated TB meningitis, I aim to define key determinants of function in this crucial cell type.

PI_NAMEs: BOLD, TYLER DALLAS (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Active Sites;Activities of Daily Living;Affinity;Antigen Targeting;Antigens;Binding;Blood;career development;Cause of Death;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Cerebrospinal Fluid;Characteristics;Collaborations;Communicable Diseases;CRISPR interference;Cryopreserved Cell;cytokine;Data;design;Development;Disease;Epitopes;experience;Flow Cytometry;Fluorescence;Funding;Future;Gene Expression;gene repression;Genomics;global health;Goals;high dimensionality;HIV;Human;human subject;Immune;immune function;Immunity;Immunology;Impairment;in vivo;Individual;Infection;innovation;Interferon Type II;International;Intrinsic factor;Medicine;Meningeal Tuberculosis;Mentors;Mentorship;Minnesota;mouse model;Mus;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;novel strategies;novel vaccines;Pathogenesis;patient oriented research;Peptides;Physicians;Population;Population Heterogeneity;Positioning Attribute;professor;Program Development;recruit;Reporter;Research;response;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;Sorting;Specimen;stem;Stimulus;T cell response;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;tool;Training;Training Activity;training opportunity;transcriptomics;translational research program;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Uganda;Universities;vaccine candidate;vaccine development;Work

PROJECT_TITLE: Determinants of antigen specific CD4 T cell function in tuberculosis

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cerebrovascular;Cocaine;Coronaviruses;Drug Abuse (NIDA only);Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The SARS-CoV-2 virus, the virus responsible for the COVID-19 pandemic, can damage not only lung barrier function but also the blood brain barrier by an unknown mechanism. Stimulant drugs of abuse such as cocaine also can damage the blood brain barrier, allowing increased access of toxins and microbes into the central nervous system. Tis research will determine the mechanism underlying blood brain barrier damage produced by the SARS-CoV-2 spike protein and the potential interaction with cocaine. The results will provide important insight into the potential consequences of contracting the COVID-19 virus by persons with stimulant use disorders.

PI_NAMEs: BRAILOIU, GABRIELA CRISTINA;UNTERWALD, ELLEN M (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: 2019-nCoV;ACE2;Acute;Adherens Junction;Affect;antagonist;Binding Proteins;Biological Models;Blood - brain barrier anatomy;blood damage;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Body System;brain endothelial cell;brain tissue;Calcium;Calcium Signaling;capsule;Cell surface;Cells;Cellular Stress;Central Nervous System;central nervous system injury;Cerebrovascular system;Chronic;Clinical;Cocaine;cocaine exposure;Contracts;COVID-19;COVID-19 pandemic;COVID-19 patient;Cytoskeleton;Data;Dependence;drug of abuse;electric impedance;Elements;Endothelial Cells;Event;Genetic;Health;Homeostasis;Homologous Gene;Impairment;In Vitro;in vitro Model;in vivo;in vivo evaluation;Infection;insight;Investigation;Jupiter;Knowledge;Lung;Microbe;Microscopy;Microtubules;Mitochondria;Molecular Chaperones;NAADP;Neurologic Symptoms;novel therapeutic intervention;Organ;pathogen;Pathway interactions;Permeability;Persons;pharmacologic;Process;Proteins;psychostimulant;Rattus;Reactive Oxygen Species;real time monitoring;receptor;Reporting;Research;Role;SARS coronavirus;SARS-CoV-2 exposure;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Second Messenger Systems;sigma-1 receptor;Signal Transduction;Signaling Protein;Stimulant;stimulant use disorder;Structure;Testing;Tight Junctions;Toxin;trafficking;Vascular Endothelial Cell;Viral;Viral Proteins;Virus

PROJECT_TITLE: SARS-CoV-2 signaling and interactions with stimulant drugs of abuse via Sigma-1R: Impact on the BBB


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative A crucial priority for combatting the global TB epidemic is shortening the length of treatment required to reliably cure tuberculosis. Through this proposal we will establish the importance of continued bacterial activity and replication during treatment which could be paradigm shift for understanding the basis of treatment-shortening drugs and accelerating the development of more efficacious, shorter regimens. This proposal represents an important step towards our long-term goal: a paradigm shift for TB drug development pipelines and clinical trials away from culture-based metrics of bacillary load to a new model in which decisions are based on markers of drug impact on the pathogen's physiologic state.

PI_NAMEs: VOSKUIL, MARTIN INUA (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acceleration;Aerosols;Affect;Bacillus;bactericide;Bacteriology;Benchmarking;Biological;Biological Assay;Cell Physiology;Chronic;Clinical Trials;design;Development;DNA biosynthesis;Dose;Drug Combinations;Drug Design;drug development;drug discovery;Drug Evaluation;Drug Exposure;Drug Kinetics;Drug Tolerance;effective therapy;Epidemic;experimental study;Foundations;Funding;Goals;In Vitro;in vivo;Inbred BALB C Mice;innovation;insight;Length;Lesion;lung lesion;Measures;Microscopic;Microscopy;Modeling;Molecular;mouse model;Mus;Mycobacterium tuberculosis;novel;pathogen;Penetration;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Physiological Processes;Population;portability;preclinical development;Regimen;Residual state;response;Ribosomal RNA;RNA chemical synthesis;Role;Series;Standardization;Testing;tool;treatment response;Tuberculosis;tuberculosis drugs

PROJECT_TITLE: BEYOND BURDEN: NEW TOOLS FOR TUBERCULOSIS ANTIBIOTICREGIMEN DESIGN

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative The enzyme ornithine aminotransferase (OAT) is highly upregulated in hepatocellular carcinoma (HCC). An inhibitor of OAT was shown to suppress the growth of HCC in cell culture and in two animal models with patient-derived HCC implanted. We propose to design, synthesize, and evaluate new compounds for their selectivity toward OAT and to test them as inactivators of HCC and other cancers we have found with overexpressed OAT both in vitro and in vivo, as well as study the inactivation mechanisms of new inactivators.

PI_NAMEs: SILVERMAN, RICHARD B (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acute;Amino Acids;Ammonia;Animal Model;Animals;Apoptosis;Arginine;Autophagocytosis;Binding;Biological Markers;Cancer cell line;Cancer Etiology;cancer therapy;carboxylate;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Cycle Regulation;Cell Line;Cell Proliferation;Cell Proliferation Regulation;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Chemotherapy-Oncologic Procedure;Colon Carcinoma;comparative;Complex;Computer Models;Crystallography;design;Dialysis procedure;Drug Kinetics;Electrodes;Encephalopathies;enzyme pathway;enzyme structure;Enzymes;Fluoride Ion;Genes;Glioblastoma;Glutamates;Glutamine;Goals;Growth;Growth Inhibitors;Human;Hydroxyproline;Implant;improved;In Vitro;in vivo;inhibitor;Intoxication;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;men;Metabolism;Modeling;Modification;molecular dynamics;molecular modeling;mouse model;Mus;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Organoids;Ornithine;Ornithine-oxo-acid aminotransferase;overexpression;Oxidases;Oxidoreductase;Pathway interactions;patient derived xenograft model;Patients;Plasma;Primary carcinoma of the liver cells;Prognosis;Proline;Proline Dehydrogenase;Property;Pyridoxal Phosphate;pyrroline;pyrroline 5 carboxylate reductase;Radiation therapy;Recovery;Reporting;Resistance;Roentgen Rays;screening;side effect;spheroids;Structure;Study models;Systemic Therapy;Testing;therapy resistant;Toxic effect;transcriptome sequencing;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Woman;X-Ray Crystallography;Xenograft procedure;α-Fetoproteins

PROJECT_TITLE: Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Astrocytes are non-neuronal cells which are key components of cortical circuits underlying goal-directed, learned behavior, yet their mechanisms are poorly understood. We will examine the role of astrocyte-neuron circuits in mediating critical components of reinforcement learning that involve norepinephrine release, using cutting edge experimental methods combined with computational models. These findings will provide insight into how dysregulation of astrocyte function may influence brain disorders and diseases.

PI_NAMEs: SUR, MRIGANKA  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Affect;Astrocytes;Behavior;behavior measurement;Behavioral;behavioral outcome;Biological;Brain;Brain Diseases;Calcium;Calcium Signaling;cell type;Complex;Computer Analysis;Computer Models;Corpus striatum structure;Data;Decision Making;density;Dependence;designer receptors exclusively activated by designer drugs;Development;dimensional analysis;Dopamine;Electrophysiology (science);Environment;Equilibrium;Exhibits;Functional disorder;functional outcomes;Genetic;genetic manipulation;Goals;Image;in vivo;innovation;insight;learned behavior;Learning;learning algorithm;Linear Models;locus ceruleus structure;Measures;Mediating;Memory;Methods;millisecond;Modeling;Motor Cortex;Mus;neural;Neural Network Simulation;Neuroglia;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;neurotransmission;Norepinephrine;novel;optogenetics;Outcome;Performance;Phase;Policies;Population;Population Analysis;Population Dynamics;Prefrontal Cortex;Psychological reinforcement;Punishment;recurrent neural network;response;Rewards;Role;Signal Transduction;spatiotemporal;Stimulus;success;Synapses;System;Task Performances;theories;two-photon;Uncertainty;Update;Work

PROJECT_TITLE: Neuron-astrocyte mechanisms of norepinephrine in goal-directed learning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Digestive Diseases;Genetics;Heart Disease;Liver Disease;Lung;Pediatric;Prevention;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE The goal of this project is to improve our understanding of pulmonary arteriovenous malformations (PAVMs), which are common sequelae of surgical palliation for univentricular congenital heart disease. To achieve this goal, we will study a circulating protein (soluble vascular endothelial growth factor receptor 1; sVEGFR1), which we recently identified as a candidate factor that may prevent PAVMs. By studying the role of sVEGFR1 in vascular remodeling and PAVM prevention, we anticipate that this new knowledge will improve our understanding of pulmonary microvascular biology and may lead to development of targeted medical therapies for patients with univentricular congenital heart disease and PAVMs.

PI_NAMEs: SPEARMAN, ANDREW D (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Address;angiogenesis;Animal Model;Animals;Arteries;Binding;Biology;Blood;Blood specimen;Blood Tests;Blood Vessels;Brain;brain arteriovenous malformations;career development;Cell Survival;Cells;Child;Circulation;Clinical;Clinical Skills;Coculture Techniques;Collaborations;congenital heart abnormality;Development;Diffuse;Endothelial Cells;exercise capacity;experience;Failure;Future;Gene Expression;Goals;Hepatic;hepatic vein;Hepatocyte;Homeostasis;Hypoxia;improved;In Vitro;in vivo;Incubated;inhibitor;innovation;Institution;Investigation;Knock-out;Knockout Mice;Knowledge;Left;Ligands;Liver;Lung;lung microvascular endothelial cells;Mediating;Medical;Membrane;Microscopic;Modernization;Molecular Biology;mouse genetics;Mus;next generation sequencing;Operative Surgical Procedures;palliate;palliation;Pathologic;Pathologic Neovascularization;Patient Care;Patients;Perfusion;Physicians;Physiological;Physiology;Positioning Attribute;prevent;Prevention;Protein Isoforms;Proteins;Proteomics;Publishing;pulmonary arteriovenous malformation;Quality of life;Research Personnel;Risk;RNA Splicing;Role;Sampling;Science;Scientist;Serum;Signal Transduction;single-cell RNA sequencing;skills;Slice;Source;Structural defect;Superior vena cava structure;Techniques;Testing;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Transgenic Animals;vascular abnormality;vascular bed;Vascular Endothelial Cell;Vascular Endothelial Growth Factor Receptor-1;Vascular Endothelial Growth Factors;Vascular remodeling;Veins;Walking

PROJECT_TITLE: Investigation of hepatic factor in pulmonary arteriovenous malformations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: We propose an innovative approach toward rapid and facile next generation neutralization resistance tests based on direct detection and quantification of antibody-target binding within the native virus populations of people living with HIV. The underlying premise is that potent bnAb neutralization ensues because of virion binding; while escape variants are by nature poorly (or are not) immunoreactive. Successful translation of this concept would provide valuable new tools to boost the efficiency and quality of bnAb trials and meet the needs.

PI_NAMEs: LEWIS, GEORGE K;RAY, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Antibodies;antibody detection;Antibody Therapy;Binding;Biological Assay;Blood Tests;breakthrough infection;Certification;Clinical;Clinical Laboratory Improvement Amendments;Clinical Trials;Coculture Techniques;Combined Modality Therapy;Complex;Consumption;Dedications;Detection;detection assay;detection method;DNA sequencing;emerging virus;Enrollment;Epitopes;Exhibits;experience;experimental study;Fluorescence;Goals;HIV;HIV resistance;HIV/AIDS;Human;immunoreactivity;In Vitro;innovation;instrument;Label;Laboratories;Liquid substance;Methods;multiplex assay;Nature;neutralizing antibody;next generation;Participant;Performance;Peripheral Blood Mononuclear Cell;Persons;Phase;Plasma;Population;Predictive Value;Predisposition;Preparation;pressure;Prevention;Prevention trial;Procedures;Production;prospective;prototype;rapid test;Reproducibility;research clinical testing;Resistance;Sampling;screening;Sensitivity and Specificity;Signal Transduction;Specific qualifier value;Specificity;Specimen;Spectrum Analysis;Standardization;stem;System;Technology;Testing;Time;Tissues;tool;transcriptome sequencing;Transference;Translating;Translations;treatment trial;Variant;Viral;viral detection;Virion;Virus;Virus Latency;volunteer

PROJECT_TITLE: Detection Assays for Virion Susceptibility to HIV Broadly Neutralizing Antibodies in Plasma and Culture Fluids


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

PHR: Project Narrative Cognitive deficits and impairment, including Alzheimer’s disease and related dementias (ADRD), are highly prevalent among older adults and have devastating consequences to families and entire communities. Responding to increasing calls for early detection of cognitive impairment, our proposed project will offer primary care providers affordable, scalable means to conduct remote, smartphone-based assessment of cognitive function during telemedicine visits.

PI_NAMEs: NOWINSKI, CINDY J. (contact);WOLF, MICHAEL S

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Abbreviations;Address;Adult;adverse outcome;Affect;Age;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Ambulatory Care;Behavioral;Caregivers;Caring;case finding;Cellular Phone;Chronic;Client;Clinic;Clinical;Clinical Trials;Cognitive;Cognitive aging;Cognitive deficits;cognitive function;cognitive testing;cohort;Cohort Studies;Communication;Communities;comorbidity;Coronavirus;COVID-19;Data;Dementia;Detection;Development;Diagnosis;Early Diagnosis;effectiveness testing;Electronic Health Record;Ensure;Family;Family Process;Federally Qualified Health Center;Feedback;field study;Future;Gender;Goals;Healthcare;Healthcare Systems;human old age (65+);Impaired cognition;Impairment;innovation;Internal Medicine;Interviewer;Link;Managed Care;Measurement;Measures;Medicare;Medicine;mild cognitive impairment;mobile application;Modification;National Institute of Neurological Disorders and Stroke;Neurologic;older adult;older patient;Paper;Patient Care;Patient Recruitments;Patients;Persons;practice setting;Preparation;Primary Care;primary care patient;primary care practice;primary care provider;primary care setting;Protocols documentation;Provider;Race;Readiness;remote visit;response;Risk;Sampling;Self Administration;smartphone application;smartphone based assessment;Socioeconomic Status;Standardization;symposium;Technology;telehealth;Telemedicine;Testing;tool;Training;United States National Institutes of Health;uptake;Validation;Visit;wellness visit;Work

PROJECT_TITLE: Development and Validation of a Telehealth Strategy for Routine Detection of Cognitive Impairment in Primary Care: The MyCog Mobile Assessment

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Depression;Mental Health;Neurosciences;Pain Research;Prevention;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Addictive disorders such as alcoholism share bidirectional links and common neural pathways with chronic pain syndromes, such that protracted pain may affect alcohol use patterns, and chronic alcohol use may precipitate or otherwise influence pain responses. The proposed research is an interdisciplinary approach that aims to examine the association between alcohol use disorder (AUD) and chronic pain, and predict the risk of chronic pain development in AUD patients in relation to their alcohol abuse history.

PI_NAMEs: MALEKI, NASIM  (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: addiction;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol relapse;alcohol risk reduction;alcohol use disorder;alcohol use initiation;Alcoholism;Alcohols;allodynia;Analgesics;Anxiety;biomarker identification;Brain;Brain Stem;career development;central sensitization;Characteristics;Chronic;chronic alcohol ingestion;chronic back pain;chronic pain;Chronic pain syndrome;chronic painful condition;cohort;cross disciplinary program;Data;Databases;depressive symptoms;Deterioration;Development;Diffusion;Disease;Down-Regulation;drinking;Early Diagnosis;experience;Functional disorder;Heavy Drinking;Hippocampus;Hyperalgesia;Impairment;Individual;insight;interdisciplinary approach;Interdisciplinary Study;Intervention;Link;Major Depressive Disorder;Mediating;member;men;Mental Depression;Mentored Research Scientist Development Award;Mentorship;Modeling;Motivation;neural;Neural Pathways;neuroadaptation;neuroimaging;neuropsychiatry;Neurosciences;Nociception;non-alcoholic;Pain;pain chronification;pain perception;pain processing;Pain Research;Pain Threshold;Pathway interactions;Patients;Pattern;Play;Predictive Factor;predictive modeling;Predisposition;Prefrontal Cortex;problem drinker;Process;Recording of previous events;Relapse;Reporting;Research;response;Rewards;Risk;Risk Factors;risk prediction;Risk Reduction;Role;Sensory;sex;Spinal Cord;Statistical Models;Stimulus;Stress;stress symptom;Structure;Symptoms;System;Testing;Training;Up-Regulation;Woman

PROJECT_TITLE: Identifying Markers of Chronic Pain Development in Alcoholism

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Cancer

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: I propose to utilize chemoproteomics-enabled covalent ligand discovery platforms to discover new E3 ligase recruiters for targeted protein degradation applications and develop a new cancer drug discovery paradigm for targeted protein stabilization (TPS) for deubiquitinating and stabilizing tumor suppressors, through the discovery and application of deubiquitinase recruiters.

PI_NAMEs: WARD, CARL  (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: activity-based protein profiling;Address;Antineoplastic Agents;Award;Binding;cancer cell;cancer therapy;cancer type;Chemicals;chemoproteomics;Complex;drug discovery;Environment;Explosion;Fellowship;Glues;Goals;graduate student;Grant;Impairment;Institution;International;Interview;Knowledge;Lead;lenalidomide;Ligands;Link;Malignant Neoplasms;Maps;Mentors;Mining;Molecular;notch protein;novel anticancer drug;novel therapeutics;Paper;Pathogenicity;pharmacologic;Phase;Positioning Attribute;Postdoctoral Fellow;professor;protein degradation;protein function;Proteins;Proteome;Proteomics;Public Speaking;receptor;recruit;Research;Research Project Grants;Resources;responsible research conduct;screening;Site;skills;small molecule;success;Sumoylation Pathway;symposium;targeted cancer therapy;technological innovation;Technology;tenure track;Thalidomide;Therapeutic;Time;Tumor Suppressor Proteins;ubiquitin isopeptidase;ubiquitin-protein ligase;Writing

PROJECT_TITLE: Expanding the scope of protein degradation and stability using chemoproteomic platforms


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a devastating neurodegenerative disease affecting about 5 million Americans over the age of 65, and this number is projected to increase 2-3 folds by 2050. Despite the unequivocal genetic links between microglia-specific gene mutations and late-onset AD, how AD-relevant subsets of microglia are regu- lated and how they contribute to AD pathology remain unknown. By investigating these important microglial subsets, this application will shed light on the cellular and molecular mechanisms of AD and lay the groundwork for the development of precise microglia-based interventions to treat AD.

PI_NAMEs: LI, QINGYUN  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;amyloid pathology;Amyloidosis;Apolipoprotein E;Bioinformatics;Brain;Cells;cohort;Deposition;Development;Diphtheria Toxin;Disease;Disease associated microglia;Disease Progression;disorder control;Drug resistance;Elements;Enhancers;epigenetic memory;Epigenetic Process;epigenetic profiling;Event;Gene Expression;Gene Modified;Gene Mutation;Genes;Genetic;Genetic Markers;genetic signature;Genetic Transcription;genomic locus;glial activation;Goals;Heterogeneity;Human;Human Genetics;human old age (65+);Immune;Immunity;In Vitro;in vivo;insight;Intervention;Knock-out;Knowledge;Late Onset Alzheimer Disease;Life;Link;Maps;Memory;Microglia;Molecular;mouse model;Mus;mutant;Mutation;Names;Neurodegenerative Disorders;neuroprotection;new therapeutic target;novel;Pathologic;Phenotype;postnatal;Regulation;Research;response;Risk Factors;Role;Senile Plaques;Signal Transduction;single-cell RNA sequencing;Testing;theories;Training;transcription factor;Transcriptional Regulation;transcriptomics;Transplant-Related Disorder;Transplantation;TREM2 gene;white matter

PROJECT_TITLE: Dissecting the origin, regulation and function of microglial subsets in Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE  Low-grade inflammatory monocytes play crucial roles during both the pathogenesis of atherosclerosis. The goals of this project are to characterize novel cellular and molecular mechanisms that underlie the training of resolving monocytes capable of resolving inflammation and propagating homeostasis beneficial for the treatment of atherosclerosis.

PI_NAMEs: LI, LIWU  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;Arterial Fatty Streak;Atherosclerosis;Biological Assay;Cells;Characteristics;Data;Development;Endotoxemia;Exhibits;Feedback;Flow Cytometry;Generations;genetic approach;Goals;Homeostasis;Human;Immunologic Memory;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Mediating;Mediator;Memory;Molecular;Molecular and Cellular Biology;monocyte;Mus;Nature;Necrosis;new therapeutic target;novel;Oxidation-Reduction;Pathogenesis;peroxisome;pharmacologic;Play;prevent;recruit;Reporting;Resolution;Role;single cell sequencing;single-cell RNA sequencing;STAT1 gene;Testing;TLR4 gene;Training;Transfusion

PROJECT_TITLE: Novel mechanisms for the generation of resolving monocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(02)M]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Appropriately regulating attention in accord with current need is essential for survival, and dysregulation of this process is associated with numerous neuropsychiatric diseases, including substance use disorders and eating disorders. Our project will determine how dopaminergic circuits integrate physiological need and regulate attentional behavior. Obtaining a mechanistic understanding of how attention is regulated by these circuits will provide a foundation for developing therapeutic interventions for attentional dysfunction.

PI_NAMEs: HATTORI, DAISUKE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Affect;analog;Animals;Appearance;Architecture;Association Learning;Attention;attentional control;attentional modulation;Behavior;Behavioral;Behavioral Assay;Brain;Corpus striatum structure;Cues;Data;directed attention;Dopamine;dopamine system;dopaminergic neuron;Drosophila genus;Eating Disorders;Environment;Exhibits;experience;experimental study;flexibility;fly;Food;Food deprivation (experimental);Foundations;Functional disorder;Genetic;genetic manipulation;Goals;Hunger;in vivo;in vivo calcium imaging;interdisciplinary approach;Mammals;Mediating;Modeling;Mushroom Bodies;Nervous System Physiology;neural;neural circuit;neuromechanism;Neurons;neuropsychiatric disorder;novel;Odors;olfactory stimulus;optogenetics;Output;Physiological;Play;Process;ratiometric;Reporter;response;Role;Satiation;Sensory;sensory stimulus;Signal Transduction;Stimulus;Substance Use Disorder;Testing;Therapeutic Intervention;transcriptomics

PROJECT_TITLE: Neural circuits that mediate computation of salience

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Somatic sequence variants contribute to defects in tissue function and can lead to disease. Current methods for identification of rare sequence variants often fail to identify variants in cis regulatory elements (CREs) and also fail to determine the functional effects of each mutation. We will develop a new technology that fills both of these gaps, allowing high sensitivity detection of variants in CREs and coding regions, while simultaneously annotating their effects on CRE activity.

PI_NAMEs: FAZZIO, THOMAS G. (contact);GARBER, MANUEL

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: analysis pipeline;Atlases;Catalogs;Categories;Cell Lineage;cell type;Cells;chromatin protein;Code;computational pipelines;Consultations;cost;cost effective;Custom;Data;Data Analyses;Defect;detection sensitivity;Development;Disease;DNA Transposable Elements;Enhancers;Epigenetic Process;epigenetic profiling;epigenome;epigenomics;exome;exome sequencing;falls;Fibroblasts;Follow-Up Studies;Future;Gene Expression;Genes;Genetic Transcription;Genetic Variation;Genome;genome sequencing;Genomic Segment;Genomics;Heterogeneity;human tissue;Inbreeding;Individual;insertion/deletion mutation;insight;Lead;Libraries;Maps;Measures;Methods;Molecular;Mus;Mutation;new technology;novel strategies;Nucleic Acid Regulatory Sequences;Oligonucleotides;Phase;Population;promoter;rare variant;Regulator Genes;Regulatory Element;Sampling;single-cell RNA sequencing;Somatic Mutation;Technology;Testing;Tissue Procurements;Tissue Sample;Tissues;Transcript;Variant;variant detection;whole genome;Work

PROJECT_TITLE: varCUT&Tag: A Method for Simultaneous Identification and Characterization of Sequence Variants in Regulatory Elements and Genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Data are converging around the hypothesis that the root cause of IPF is telomere dysfunction in AEC2 cells. Studies outlined in this proposal will generate data establishing molecular drivers distal to telomere dysfunction that lead to lung remodeling and whether increasing telomerase activity leads to favorable molecular and functional changes in IPF AT2 cells. These data would support the development of novel telomerase-based therapies for IPF.

PI_NAMEs: WOLTERS, PAUL J (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adenovirus Infections;Adult;Age;aged;Alveolar;Alveolar fibrosis;alveolar type II cell;Appearance;Automobile Driving;beta-Galactosidase;Biological Assay;Bleomycin;Cell Communication;Cell division;Cell Reprogramming;Cells;comparative;comparison control;Complex;Cytoprotection;Data;defined contribution;Development;Disease;Distal;DNA Damage;Dose;Elements;Epithelial Cells;Epithelium;Event;Evolution;Fibrosis;fibrotic lung;Functional disorder;Gamma-H2AX;Gene Expression;Genes;Harvest;Health;Human;human disease;idiopathic pulmonary fibrosis;inhibitor;Injury;insight;Knowledge;Length;Lung;Lung Diseases;lung regeneration;Measures;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;novel;Organoids;overexpression;Pathogenesis;Phase;Phenotype;Play;Pneumonectomy;Population;Prevalence;Production;Proliferating;Protein Array;Proteins;Pulmonary Fibrosis;Pulmonary Surfactant-Associated Protein C;Role;senescence;Serial Passage;single-cell RNA sequencing;Stains;Stimulus;stressor;Study models;System;Tamoxifen;Telomerase;telomere;Telomere Shortening;TERF1 gene;Testing;Time;TP53 gene;transcription factor;transdifferentiation;Translating

PROJECT_TITLE: Lung Remodeling Mediated by Telomere Dysfunction in Alveolar Type II Cells

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: Project Narrative The proposed project seeks to benefit public health by evaluating a four-week mindfulness-based mobile health intervention on symptoms of depression and anxiety within a symptomatic sample, with participants randomly assigned to two different dosages of mindfulness practice. Ultimately, this line of research is aimed at producing mobile technologies for depression and anxiety that are both highly accessible and optimized based on patients' needs and preferences. The current study will provide crucial training and pilot data for a future randomized controlled trial that will include a wider variety of dosage conditions and both active and waitlist control groups.

PI_NAMEs: GOLDBERG, SIMON B (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: Address;Adherence;Adult;Aftercare;Anxiety;anxiety symptoms;anxious;Award;Cellular Phone;Clinical;Clinical Research;Clinical Trials;Cognitive;Communities;Control Groups;cost;Data;Data Analyses;Data Collection;Depressed mood;depressive symptoms;Development;dosage;Dose;Ecological momentary assessment;effective intervention;Effectiveness;Emotions;Equation;Foundations;Funding;Future;Goals;Health Technology;Healthcare;Heterogeneity;implementation science;improved;Individual;Instruction;Intervention;intervention effect;Intervention Studies;K-Series Research Career Programs;Knowledge;Lead;Learning;Life;Link;Measures;Meditation;Mental Depression;Mentors;Methods;mHealth;mhealth interventions;Mind;mindfulness;mindfulness based cognitive therapy;mindfulness intervention;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;mobile computing;Modeling;Outcome;Participant;Patients;Persons;Positioning Attribute;preference;Program Acceptability;programs;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;reduce symptoms;Reporting;Research;research clinical testing;Research Project Grants;Research Training;rumination;Sampling;Services;social;Stress;Symptoms;Techniques;Testing;Thinking;Time;Training;Translational Research;trend;United States;United States National Institutes of Health;Waiting Lists;Work

PROJECT_TITLE: Mindfulness training delivered via mobile health to reduce depression and anxiety


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The identification of molecular and cellular mechanisms involved in primate cortical development and evolution is essential if we are to understand the origins of, and devise prevention and/or treatments for, genetic and environmentally caused cortical abnormalities in humans. Thus, the expected set of unique data are not only of theoretical significance, but also of considerable clinical importance as they may be relevant to disorders of our highest cognitive functions as well as our response to drugs of therapy and abuse.

PI_NAMEs: RAKIC, PASKO  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;addiction;Anisotropy;Area;Astrocytes;Automobile Driving;Axon;Bioinformatics;Biological;Birth;Brain;Brain imaging;Breeding;Bromodeoxyuridine;Calcium;Candidate Disease Gene;Cell Line;Cells;Cerebral cortex;Cerebrum;Characteristics;Clinical;Cluster Analysis;CM-DiI;Cognition Disorders;cognitive capacity;cognitive function;Color;comparative;Consumption;Contracts;cost;Data;Development;Disease;Drug abuse;Dyes;Embryo;Environment;Event;Evolution;experimental study;Explosion;Exposure to;fetal;FGF2 gene;Fibroblast Growth Factor;Fibroblasts;frontal lobe;Gene Cluster;Gene Expression;gene network;Genes;Genetic;Genetic Determinism;gliogenesis;Goals;Grant;Growth;Human;human induced pluripotent stem cells;Humanities;Image;Immunohistochemistry;in utero;induced pluripotent stem cell;innovation;insight;Label;Ligands;Light;Link;lipophilicity;Macaca;Mammals;Methodology;Methods;Molecular;Monkeys;Morphogenesis;Motor;multiphoton microscopy;Mus;Nature;nerve stem cell;neural;Neuroepithelial;neurogenesis;Neuroglia;Neurons;Neuropil;neuropsychiatric disorder;neurotrophic factor;newborn neuron;nonhuman primate;notch protein;Oligodendroglia;overexpression;Pathogenesis;Pathologic;Pathway Analysis;Pattern;Pharmacotherapy;Phenotype;Positioning Attribute;Predisposition;Prefrontal Cortex;prenatal exposure;Prevention;primate development;Primates;Primordium;Process;Proliferating;Proteins;Radial;Regulatory Element;Research;Resolution;response;Rodent;Role;Sampling;Sensory;single cell mRNA sequencing;single-cell RNA sequencing;Skin;somatosensory;Specificity;stem cells;subventricular zone;Surface;Synapses;System;Testing;theories;Time;transcriptome;transcriptomics;white matter;Work

PROJECT_TITLE: Origin of Cortical Species-specific Distinctions

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Cancer;Genetics;Skin Cancer

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer occurs when cells acquire changes that convert them from a normal to a malignant state. Oncogene- induced senescence is a cellular brake that prevents aberrant cells from becoming cancer; and oncogene- induced senescence also controls the tumor microenvironment which adds mechanistic complexities to the processes of tumorigenesis and metastasis – and therapeutic successes or failures. Therefore, it is important to investigate the pathways that control oncogene-induced senescence to understand how cancer may be prevented, diagnosed, and clinically treated.

PI_NAMEs: CHIPUK, JERRY EDWARD (contact)

PROGRAM_OFFICER_NAME: SALNIKOW, KONSTANTIN

PROJECT_TERMS: 3-Dimensional;Acetylation;Apoptosis;Benign;Biochemical;Biology;cancer cell;Cell Survival;cell type;Cells;Cellular biology;Cellular Stress;Clinic;Clinical;cohort;Cutaneous Melanoma;cytokine;Data;data integration;Data Set;Development;Diagnosis;Disease;disease phenotype;Distal;Dysplastic Nevus;Epigenetic Process;Eukaryota;experience;experimental study;Failure;gain of function;Gene Expression;Genetic Transcription;high risk;Human;Immune;Immunocompetent;In Vitro;in vivo;in vivo Model;insight;interest;Laboratories;Lesion;Link;Literature;loss of function;Lymphocyte;Malignant Neoplasms;malignant state;Mediating;melanocyte;Melanoma;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Mus;Neoplasm Metastasis;Nevus;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Oncogenic;Organelles;Oxidative Phosphorylation;Pathway interactions;Patients;permissiveness;Phenotype;Positioning Attribute;premalignant;Premalignant Cell;prevent;Process;Production;Prognostic Marker;programs;promoter;Proteins;Quality Control;recruit;repaired;response;Risk;Sampling;senescence;Signal Pathway;Signal Transduction;Skin;skin lesion;Stress;success;System;Therapeutic;Tissues;transcriptome;transcriptome sequencing;tumor;tumor microenvironment;tumorigenesis

PROJECT_TITLE: The Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(02)M]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: AUPPERLE, ROBIN L;PAULUS, MARTIN P. (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 15/21 ABCD-USA Consortium: Research Project Site at LIBR


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Alcoholic liver disease (ALD) is one of the most common forms of chronic liver disease in the United States and results in significant morbidity and mortality. This proposal will test the novel paradigm shifting hypothesis that stressed hepatocytes in ALD released microRNA enriched extracellular vesicles (EVs) that promote the transition from chronic asymptomatic alcoholic steatohepatitis (ASH) to fatal alcoholic hepatitis (AH) and are released into the bloodstream providing a signature or “barcode” that can be used to develop novel mechanism-based biomarkers of ALD.

PI_NAMEs: FELDSTEIN, ARIEL  (contact);TSUKAMOTO, HIDEKAZU

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Address;Alcoholic Fatty Liver;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Animal Model;Bar Codes;Biological Markers;Biology;Blood;Blood Circulation;Cell Communication;Cells;Cellular biology;Chronic;chronic alcohol ingestion;chronic liver disease;Communication;Country;Data;Deoxyribonucleotides;design;Development;Diagnosis;Disease;Disease Progression;Effector Cell;efficacious treatment;Encapsulated;Enzymes;exosome;extracellular;extracellular vesicles;Fatty Liver;Fibrosis;Generations;Genes;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human;IL17 gene;in vitro Assay;in vivo;Infiltration;Inflammasome;Inflammation;Inflammatory;Investigation;Lipids;Liquid substance;Liver;liver biopsy;Liver Fibrosis;Macrophage;Macrophage Activation;Mediating;Messenger RNA;MicroRNAs;Mitochondrial DNA;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nonalcoholic steatohepatitis;noninvasive diagnosis;novel;Organelles;particle;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Pattern;Penetration;personalized therapeutic;Phenotype;Plasma;prevent;Process;Proteins;response;RNA;Role;Severity of illness;Signal Pathway;Signal Transduction;Small Interfering RNA;Staging;Sterility;Stress;Surface;Tail;Testing;Therapeutic;therapeutic RNA;Toll-like receptors;transcriptome sequencing;transcriptomics;Translations;United States;Untranslated RNA;Veins;vesicular release

PROJECT_TITLE: Hepatocyte-derived extracellular vesicles in alcoholic liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(04)]