NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Narrative While a large amount of observations in humans and experimental animals has documented a key role for acetylcholine (ACh) in learning and memory, the underlying cellular and circuit mechanisms have not been elucidated. This application uses state-of-the-art and innovative behavioral, functional and genetic methods to test novel hypotheses and advance our understanding of the cellular and circuit mechanisms by which ACh mediates its effects on learning and memory formation in the cerebral cortex. These studies are important for the understanding and treatment of neurological diseases that cause cognitive impairments such as schizophrenia and Alzheimer’s disease.

PI_NAMEs: RUDY, BERNARDO  (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Ablation;Acetylcholine;Acetylcholinesterase Inhibitors;Alzheimer's Disease;Amnesia;Animal Experiments;Anterograde Amnesia;Anti-Cholinergics;Area;Arousal;Association Learning;Attention;Behavior;Behavioral;Biochemical;Brain;cell cortex;cell type;Cells;Cerebral cortex;cholinergic;cholinergic neuron;Cholinergic Receptors;Cholinesterase Inhibitors;Cognitive;cognitive control;cognitive function;common treatment;Conditioned Stimulus;Delirium;Dementia with Lewy Bodies;Disease;Dissection;Electrophysiology (science);Enzymes;excitatory neuron;experimental study;Forcible intercourse;Functional disorder;Genetic;genetic approach;Goals;Grant;Human;Impaired cognition;In Vitro;inhibitor;innovation;insight;Interneurons;Intervention;Intoxication;Investigation;Learning;Learning Disturbances;Link;Literature;Mediating;Memory;Memory impairment;memory process;Methods;microstimulation;Molecular;Monitor;Motor;Muscarinic Acetylcholine Receptor;Muscarinics;Nerve Degeneration;Nervous System Disorder;neurocognitive disorder;Neurodegenerative Disorders;Neuromodulator;Neuromuscular Junction;Neurons;neuroregulation;Neurotransmitters;novel;operation;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Phase;Physiological;Physiology;Process;Psychological reinforcement;receptor;Regulation;Reporting;Research;response;Rewards;Schizophrenia;Scopolamine;sensor;Sensory;Signal Transduction;Somatosensory Cortex;Stimulus;Synapses;System;Task Performances;Technology;Testing;Time;two photon microscopy;Vagus nerve structure;Vibrissae;virtual;Work

PROJECT_TITLE: Cholinergic Mechanisms of Associative Learning in Cortical Circuits

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Overall – PROJECT NARRATIVE Decades of research have generated new knowledge and tools with the potential to prevent all new HIV infections and improve the lives of all persons living with HIV. Unfortunately, reality falls far short of these goals. The Tennessee Center for AIDS Research leverages complementary strengths of its four partner institutions to have broad and substantial impact on the HIV epidemic.

PI_NAMEs: MALLAL, SIMON ALEXANDER (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Academic Medical Centers;Acquired Immunodeficiency Syndrome;Address;Affect;African American population;Area;career development;Collaborations;Communities;community engaged research;community engagement;community organizations;community partnership;data dashboard;design;Development;Disease Outbreaks;Doctor of Philosophy;Environment;Epidemic;experience;Extramural Activities;falls;Fostering;Funding;Goals;Health;Health Sciences;high risk;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;implementation science;improved;Institution;Knowledge;Laws;Leadership;Medical;medical schools;Minority Groups;Mission;multidisciplinary;Needle-Exchange Programs;next generation;novel;Persons;Populations at Risk;Postdoctoral Fellow;prevent;Public Policy;Research;Research Personnel;Resources;Rural;Science;Scientist;Southeastern United States;success;surveillance data;synergism;Tennessee;tool;translational impact;Underserved Population;United States;United States National Institutes of Health;Vision;Work;working group

PROJECT_TITLE: Tennessee Center for AIDS Research (TN-CFAR)


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Prevention


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative: The hallmarks of chronic kidney disease (CKD) include fibrosis, increased inflammatory responses, and dysregulated mineral metabolism, which are all especially problematic in aged patients and strongly associated with morbidity and mortality. There are no direct therapies for the fibrosis of CKD, and it remains unclear whether targeting this manifestation using broad spectrum drugs is feasible in clinical practice because most drugs that decrease fibrosis in pre-clinical models target multiple essential pathogenic pathways (eg, renin-angiotensin-aldosterone system blockade). Thus, our proposed studies are innovative as we will test for the first time whether a novel transient LNP-FAPCAR CAR-T cell therapy can be used to reduce CKD fibrosis in the aged, and whether this treatment improves mineral metabolism, a key pathology that also has inadequate treatments.

PI_NAMEs: WHITE, KENNETH E (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Adenine;Adult;Affect;aged;Aging;aging population;Anemia;Antibodies;Biochemical;bone;CAR T cell therapy;Cell surface;Cells;chimeric antigen receptor T cells;Chronic Kidney Failure;clinical investigation;clinical practice;Clinical Trials;Collagen;Combined Modality Therapy;coronary fibrosis;Deposition;design;Diet;Disease;Disease Outcome;Effectiveness;Endocrine Bone Diseases;Etanercept;Evaluation;FDA approved;fibroblast growth factor 23;fibroblast-activating factor;Fibroblasts;Fibrosis;functional improvement;Gene Expression;Genes;heart function;Histologic;Histology;Hormones;Human;Immunofluorescence Immunologic;improved;in vivo;Individual;Infarction;Inflammation;Inflammatory Response;innovation;inorganic phosphate;Interruption;Investigation;Kidney;kidney fibrosis;Lesion;lipid nanoparticle;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Metabolism;Minerals;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Expression;Mus;Musculoskeletal System;Myofibroblast;novel;old mice;Outcome;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pirfenidone;Plasma;pre-clinical;Pre-Clinical Model;pre-clinical therapy;Preclinical Testing;Prevention;Proteins;Pulmonary Fibrosis;receptor;Renal function;Renin-Angiotensin-Aldosterone System;Rodent Model;Sampling;Serine Protease;Stains;T-Lymphocyte;Testing;Time;Tissues;TNF gene;transcriptomics;Translating;Vitamin D;Wild Type Mouse;Work;wound healing

PROJECT_TITLE: Directly targeting renal fibrosis in the aged with CKD using in vivo CAR-T cell therapy

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Drug-resistant Neisseria gonorrhoeae is listed as one of the 5 urgent threats in the US by the CDC and one of the 6 high priority pathogens by the WHO. The objective of this project is to create workflows to sequence N. gonorrhoeae from non-culture based clinical urine and extragenital specimens and use phylogenetic analysis from resulting genomic data to enhance detection of emerging strains of N. gonorrhoeae with reduced antimicrobial susceptibility. Knowledge gained would transform future genomic N. gonorrhoeae studies by allowing us to better understand transmission networks across broader reaches of risk groups who are often excluded from traditional culture-based surveillance.

PI_NAMEs: POPOVICH, KYLE JEANNE (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Anti-microbial susceptibility;Antibiotic Resistance;Antimicrobial Resistance;authority;Bacteria;bacterial genome sequencing;Chicago;Cities;Clinic;Clinical;clinical care;co-infection;Collaborations;Communities;Community Networks;community setting;community transmission;cooking;cost effective;County;COVID-19 pandemic;Dedications;Detection;Drug-resistant Neisseria Gonorrhoeae;emerging antimicrobial resistance;Epidemiology;ethnic disparity;Exclusion;Female;Frequencies;Funding;Future;Genitalia;Genitourinary system;genome sequencing;genomic data;Genomics;Guide prevention;Health;Healthcare;high risk;Hour;improved;Individual;Infection;International;Knowledge;male;men;men who have sex with men;Methodology;Methods;Modeling;Molecular;Monitor;Multi-Drug Resistance;Neisseria gonorrhoeae;Nucleic Acid Amplification Tests;Organism;pandemic disease;pathogen;Patients;Pharyngeal structure;Phylogenetic Analysis;Population;Population Surveillance;priority pathogen;Public Health;public health intervention;racial disparity;Recommendation;Rectum;Reporting;Resistance;Risk;safety net;Sampling;screening;Sexual Health;Sexually Transmitted Diseases;Site;Specimen;surveillance data;Swab;Testing;tool;transmission process;Urethra;Urine;Vagina;Variant;variants of concern;whole genome;Work

PROJECT_TITLE: Whole Genome Sequencing of N. gonorrhoeae from Non-Culture Based Clinical Specimens to Surveil for Emerging Resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-H (02)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: TUSCALOOSA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Streptococcus agalactiae (Group B Streptococcus, GBS), is an opportunistic pathogen that can cause pneumonia, skin infections, sepsis, and is the leading cause of neonatal meningitis. Discovery of host- pathogen interactions remains crucial as currently there is no vaccine available. Using CRISPRi technologies, we will generate knockdowns in every gene present in the hypervirulent GBS strain COH1 that will provide the field with a rapid method of testing phenotypes of interest prior to classical mutagenesis strategies.

PI_NAMEs: KIM, BRANDON JONATHAN (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Antibiotic Therapy;Bacteria;Binding;Blood - brain barrier anatomy;Collaborations;Communities;CRISPR interference;Cryopreservation;deep sequencing;design;Disease;DNA Binding;ds-DNA;Environment;Epithelium;Escherichia coli;Essential Genes;Gastrointestinal tract structure;Genes;Genome;Goals;Group B Streptococcus colonization;Guide RNA;gut colonization;Hemolysin;Homologous Gene;Immune Evasion;Immunocompromised Host;indexing;Individual;Infectious Skin Diseases;interest;Investigation;knock-down;Laboratories;Letters;Libraries;Ligation;member;Meningitis;Microbe;Mucous Membrane;Mutagenesis;mutant;Mutation;Neonatal meningitis;neonate;novel;nuclease;Operon;opportunistic pathogen;pathobiont;pathogen;Pathogenesis;Persons;Phenotype;Plasmids;Pneumonia;Positioning Attribute;rapid technique;reproductive tract;Research;Research Personnel;Resources;screening;Sepsis;Serotyping;Streptococcus Group B;Sucrose;Techniques;Technology;Temperature;Testing;Therapeutic Intervention;tool;transposon sequencing;treatment group;vaccine access;Vaccines;vector;Virulence Factors;Work

PROJECT_TITLE: A Group B Streptococcus ordered CRISPR interference library to investigate host-pathogen interactions

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Low income, ethno-racial minoritized children exhibit higher rates of persistent mental health disorders and are at greater risk for lags in identification and treatment creating a mental health equity concern for the most vulnerable. Our team developed and tested an ethno-racially matched, peer-based family navigator program for Head Start preschoolers with developmental concern bringing about increased caregiver engagement in child services. The current proposal is an adapted family navigation program for caregivers of young children at risk for mental health conditions to increase engagement in services and improve child mental health outcomes.

PI_NAMEs: BURKETT, KAREN  (contact);KAMIMURA-NISHIMURA, KELLY

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: active control group;Address;Advocacy;aged;antisocial behavior;behavioral impairment;Belief;Black race;Caregivers;Case Series;Child;Child Behavior;Child Mental Health;child services;comparison control;Control Groups;data dashboard;Development;Developmental Delay Disorders;distrust;early childhood;Early Diagnosis;Early treatment;Education;effectiveness trial;Elements;emotion regulation;empowerment;ethnoracial minority;Exhibits;Family;Feasibility Studies;Feedback;Focus Groups;Funding;group intervention;Head Start Program;health equity;health service use;Healthcare;Impaired cognition;Impairment;Improve Access;improved;Individual;Intervention;Knowledge;language impairment;Latinx;Learning;Long-Term Effects;Low income;Manuals;Measurement;Mental disorders;Mental Health;Mental Health Services;Minority;minority children;Minority Groups;Modeling;Monitor;motor impairment;novel;Outcome;peer;Phase;Pilot Projects;pilot test;Positioning Attribute;prevent;primary care provider;programs;Race;Readiness;Recommendation;recruit;Research;Risk;Rural;Sampling;Schools;Services;social stigma;Substance abuse problem;success;suicidal;Symptoms;System;teacher;Testing;Trainers Training;Training;treatment services;Trust;Update;web site;Work

PROJECT_TITLE: Engaging Mental Health Services for Preschoolers at Risk

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Pediatric;Prevention;Tobacco

ORG_CITY: OMAHA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative The overarching goal of this feasibility study is to develop and test a novel Parents-helping-Parents for youth Vaping Cessation (PhP-VX) program, which will be built on our prior studies and inputs from an advisory board including both parents and adolescents (Aim 1). We will conduct a randomized control trial with 100 dyads recruited from pediatric EHR systems to determine the feasibility and acceptability of the program (Aim 2) and explore the effectiveness of the intervention (Aim 3).

PI_NAMEs: DAI, HONGYING DAISY (contact);WINICKOFF, JONATHAN P

PROGRAM_OFFICER_NAME: MAYNE, RACHEL G

PROJECT_TERMS: 18 year old;2 arm randomized control trial;Abstinence;acceptability and feasibility;Address;Adolescent;adolescent substance use;Advocacy;Age;aged;Caregivers;Child;Childhood;Clinic;Clinical;Clinical Data;Communities;community organizations;Control Groups;cost effective;Cotinine;design;e-cigarette aerosols;Education;effective intervention;Effectiveness;Effectiveness of Interventions;efficacy testing;Electronic cigarette;electronic cigarette use;electronic cigarette user;Electronic Health Record;electronic health record system;Eligibility Determination;Enrollment;Environment;epidemiology study;ethnic diversity;expectation;Exposure to;Family;Feasibility Studies;feasibility testing;follow-up;Frequencies;Future;Goals;Growth;Health;Health Professional;high school;High School Student;improved;Intervention;intervention program;junior high school;Knowledge;Light;literacy;Marketing;Middle School Student;mobile application;Modeling;Motivation;multidisciplinary;Nicotine Dependence;novel;Outcome;parenting intervention;Parents;Participant;Pediatrics;peer coaching;peer support;Physicians;Pilot Projects;pilot test;Poison;pragmatic trial;Prevalence;primary outcome;Program Acceptability;programs;promote resilience;protective factors;Public Health;racial diversity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Research;Resources;Saliva;Smoking;social cognitive theory;social influence;substance use;success;Teenagers;Testing;Text Messaging;Time;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco products;Training;Training Activity;Translations;United States;vaper;vaping;Visit;Vulnerable Populations;Youth

PROJECT_TITLE: Parents helping Parents for Youth Vaping Cessation (PhP-VX)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE THIRD COAST CFAR OVERALL RESEARCH The Third Coast Center for AIDS Research has leveraged complementary strengths of Northwestern University, the University of Chicago, and partnering community organizations across Chicago to build a comprehensive infrastructure for multi-disciplinary, collaborative HIV research. As a result, research funding and interactions have grown in our first term. This unique and catalytic integration of disciplines and venues of HIV-related research expands in this renewal proposal, aiming to accelerate HIV elimination and improving health-span for persons living with HIV.

PI_NAMEs: D'AQUILA, RICHARD ;MUSTANSKI, BRIAN  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Adherence;African American;age acceleration;aging mechanism;aging related;aging related disease;AIDS prevention;Aquila;base;Behavioral;behavioral and social science;Behavioral Sciences;Biological Assay;Biological Markers;Blood;Caring;Cells;Chicago;Clinical;clinical phenotype;Clinical Sciences;cohort;Collaborations;Communities;community engagement;community organizations;community partners;comorbidity;Consultations;Data Analytics;Data Science;design;Development;Diagnostic;Discipline;Disease remission;Doctor of Philosophy;effective intervention;empowerment;Engineering;Epidemic;Foundations;Funding;Growth;Health;health data;Health Professional;healthspan;Heart;HIV;Illinois;Image;Immunity;implementation science;improved;Informatics;Infrastructure;innovation;Institution;interdisciplinary collaboration;Intervention;Magic;Market Research;men;Mentored Clinical Scientist Development Program;Mentors;Mission;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Outcome;Partnership Practice;Persons;Populations at Risk;pre-exposure prophylaxis;Prevention;Probability;Productivity;programs;Public Health;recruit;Reporting;Research;Research Personnel;Resources;Risk;Science;Scientist;Sleep;social;Social Sciences;Solid;Specimen;Speed;Strategic Planning;success;synergism;Systems Biology;Technology;Testing;transgender women;translational pipeline;Translational Research;Universities;Viral;Viral Pathogenesis;Viremia;virology;Vulnerable Populations;Work;working group;young men who have sex with men

PROJECT_TITLE: Third Coast Center For AIDS Research


ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Overall: Project Narrative The UCLA-CDU CFAR is located in metropolitan Los Angeles, which is a major epicenter for the AIDS epidemic, and is the most populous county in the nation, ranking second in the number of documented cases of advanced HIV disease. The UCLA-CDU CFAR seeks to catalyze and expand HIV research by providing the infrastructure to connect, support and enhance the capacity of investigators affiliated with UCLA and CDU. The UCLA-CDU CFAR will strengthen and amplify the impact of existing research activities and launch new partnerships across Los Angeles and globally through our focus on three themes: we will STOP HIV by preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission).

PI_NAMEs: CURRIER, JUDITH S.;SPENCER, LASHONDA ;ZACK, JEROME A. (contact)

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Animal Model;Area;Award;Behavioral;behavioral study;biobank;Biological Assay;California;career;Clinic;Clinical;Clinical Informatics;Clinical Laboratory Improvement Amendments;Clinical Research;Clinical Sciences;Clinics and Hospitals;Collaborations;Communication;Communities;community advisory board;community based participatory research;community based research;community engagement;community partners;cost effective;County;Data;design;Development;Disease;Disease remission;Ensure;Epidemic;Equipment;Equity;Faculty;Funding;gene therapy;Goals;Grant;health equity;Healthcare Systems;HIV;HIV Infections;HIV/AIDS;humanized mouse;Incubators;Inequity;Informatics;Infrastructure;Institution;Interdisciplinary Study;Laboratories;Leadership;Link;Los Angeles;Medical center;meetings;member;Mentors;metropolitan;Mission;Morbidity - disease rate;multidisciplinary;Neighborhoods;next generation;Participant;Pathogenesis;Persons;Pilot Projects;Policies;Population;prevent;Prevention;Procedures;Productivity;programs;Provider;Public Health Informatics;recruit;Registries;Regulation;Research;Research Activity;Research Personnel;research study;Resources;Sampling;Science;Scientist;Services;Shapes;Site;social;Structure;substance use;success;symposium;Talents;Techniques;Training;Training Activity;Translational Research;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: UCLA-CDU CFAR


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Improving the survival and healthy development of low birthweight infants is an urgent global priority, especially in low-resource settings where the risks of prematurity, neonatal hypothermia, and neonatal mortality are high. This proposal seeks to address this issue by evaluating whether offering mothers of low birth weight infants emotional, informational, and motivational support through peers and material support with a package of neonatal care related items is an effective strategy for increasing kangaroo care at home. Findings hold the potential to not only advance neonatal care in low-resource settings but may also be relevant to underserved populations in high-income countries similarly facing a high risk of neonatal mortality.

PI_NAMEs: KANYANGARARA, MUFARO  (contact)

PROGRAM_OFFICER_NAME: KOSO-THOMAS, MARION

PROJECT_TERMS: Address;Adoption;Africa;Anxiety;arm;Behavior;Behavioral;Behavioral Sciences;Birth Weight;Body Temperature;Breast Feeding;Community Health Aides;Consolidated Framework for Implementation Research;contextual factors;Control Groups;cost;Counseling;Country;delivery complications;design;Detection;Development;Devices;Economic Factors;Economics;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Eligibility Determination;Emotional;Enrollment;evidence base;Evidence based intervention;Exclusive Breastfeeding;Face;Family;family burden;feeding;Financial Hardship;Finland;follow-up;Fright;Ghana;Goals;Hand;Health;Health care facility;Health Personnel;Health Policy;Health system;high risk;Home;Home visitation;Hospitals;Household;Human Milk;hybrid type 2 design;Hybrids;Hygiene;implementation barriers;implementation facilitators;implementation framework;implementation outcomes;implementation process;implementation science;implementation strategy;improved;Income;India;Individual;Infant;Infection;innovation;Intervention;Interview;Kangaroo-Mother Care;Knowledge;low and middle-income countries;Low Birth Weight Infant;Maintenance;Measures;Methods;Modeling;Monitor;monitoring device;Mothers;Motivation;multi-component intervention;multidisciplinary;natural hypothermia;neglect;Neonatal;neonatal care;neonatal morbidity;Neonatal Mortality;Neonatology;Newborn Infant;Nutritional;Outcome;Participant;Pediatrics;peer;peer support;Population;postnatal;premature;Premature Birth;primary outcome;Public Health;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;research to practice;Resource-limited setting;Risk;scale up;Self Efficacy;skills;Skin;Soaps;social culture;Social Sciences;social stigma;Social support;sociocultural determinant;Source;source localization;standard of care;Temperature;Testing;Time;Training;Translations;trial design;Trust;Underserved Population;Use Effectiveness;Visit;Weight;Work

PROJECT_TITLE: Enhancing the Survival of Low Birth Weight Infants in Low Resource Settings using an Implementation Science Approach

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE – Overall The Duke Center for AIDS Research (CFAR) provides comprehensive infrastructure support to basic, translational, and clinical investigators conducting HIV/AIDS research. Maintaining strategic alignment with the National CFAR Mission Statement and the NIH Strategic Plan for HIV and HIV-Related Research, Duke CFAR will continue to advance toward our goals of HIV prevention and improving outcomes for people with HIV/AIDS.

PI_NAMEs: TOMARAS, GEORGIA DORIS (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Advisory Committees;AIDS prevention;Area;base;Basic Science;Censuses;Clinical;Clinical Investigator;co-infection;Collaborations;Communication;Communities;community engagement;Community Outreach;comorbidity;Development;diversity and inclusion;driving force;Education;Emerging infection;Ensure;Environment;Epidemic;Equity;Evolution;Faculty Recruitment;Fortification;Fostering;Foundations;Funding;gender diversity;Goals;Grant;Growth;health disparity;HIV;HIV/AIDS;improved outcome;Individual;Infrastructure;innovation;Institution;Investments;Lead;Leadership;medical schools;member;Mental Health;Mentors;Mentorship;Methodology;Mission;next generation;NIH Office of AIDS Research;Operative Surgical Procedures;opioid epidemic;Organ;outreach program;Persons;Policies;Prevention;Prevention Research;Process;programs;Qualifying;racial diversity;recruit;Research;Research Personnel;Research Priority;Research Support;Resource-limited setting;Resources;Role;Services;skills;Solid;Strategic Planning;Substance abuse problem;success;synergism;Training;Translating;translational scientist;treatment research;United States National Institutes of Health;Universities;Vaccine Design;vaccine evaluation

PROJECT_TITLE: Centers for AIDS Research (CFAR)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Burden of Illness;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE In the Southwest United States, Indigenous communities are disproportionately affected by morbidity and mortality related to Staphylococcus aureus infections, despite similar levels of S. aureus carriage as the general United States population. Existing strategies have not been sufficient to control disease and a better understanding of the epidemiology of S. aureus carriage is needed so that effective and feasible approaches to decolonization can be developed. This proposal will address this public health need by evaluating the molecular epidemiology of S. aureus carriage within households in an Indigenous community in the Southwest with the goal of informing the design and evaluation of decolonization interventions for prevention of S. aureus disease, to be implemented in similarly under-resourced and burdened communities.

PI_NAMEs: HAMMITT, LAURA  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adult;Affect;Antibiotic Resistance;antimicrobial;Apache;Apache Tribe;Arizona;Bacterial Infections;behavior change;burden of illness;Collaborations;Communicable Diseases;Communities;community burden;community partnership;community setting;cost;Cross-Sectional Studies;Data;design;Disease;disorder control;Disparity;Drug resistance;Education;Epidemiology;Evaluation;experience;Florida;follow-up;Funding;Future;Genomics;Goals;Health;health disparity;Healthcare Systems;hospitalization rates;Household;Indigenous;indigenous community;Individual;Infection;Infectious Skin Diseases;innovation;Intervention;Licensure;Local Anti-Infective Agents;member;methicillin resistant Staphylococcus aureus;Mission;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Allergy and Infectious Disease;Native American community;Native American Research Center for Health;Native-Born;Necrotizing fasciitis;novel strategies;Patients;Persons;pet animal;Pneumonia;Population;Prevalence;prevent;preventive intervention;programs;Public Health;Recording of previous events;recruit;recurrent infection;Regimen;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;Sepsis;social health determinants;Soft Tissue Infections;Source;Staphylococcus aureus;Staphylococcus aureus infection;Surface;Testing;Time;transmission process;tribal lands;tribal member;United States;United States Indian Health Service;United States National Institutes of Health;Universities;Vaccines;Visit;Water;White Mountain Apache;Work

PROJECT_TITLE: The molecular epidemiology of Staphylococcus aureus in households in aSouthwest Native American community with a high burden of disease

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Birth defects occur in 1 in 33 individuals and are of importance to the healthcare system. The Gabriella Miller Kids First Pediatric Research Program (Kids First) was created to understand birth defects and cancer. In the proposed studies, we will advance understanding of birth defects by the detecting, quality checking, and statistically assessing de novo variants in Kids First.

PI_NAMEs: TURNER, TYCHELE NAOMI (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Acceleration;Address;autism spectrum disorder;Child;Code;cohort;Collection;Communities;computerized tools;Congenital Abnormality;Congenital diaphragmatic hernia;Craniosynostosis;Data;data exploration;data portal;Data Set;de novo mutation;Detection;Event;Family;Future;Generations;Genes;Genetic;Genome;genome sequencing;Genomics;Grant;Haplogroup;Health Care Costs;Healthcare Systems;heteroplasmy;Human;human disease;Individual;insight;interest;Literature;Malignant Neoplasms;Mitochondria;mitochondrial genome;Molecular;Names;Neural Tube Defects;Nuclear;orofacial cleft;Outcome;Pan Genus;Parents;Pathway interactions;Pediatric Research;Phenotype;Prevalence;programs;Proteins;Research;Research Personnel;Research Project Grants;response;Sequence Alignment;Speed;Structural defect;Testing;Therapeutic;tool;United States;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: A Comprehensive De Novo Variant Callset for the Gabriella Miller Kids First Pediatric Research Program Birth Defect Data

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Neurons and astrocytes are two key cell types in the brain that collaborate to enable our thoughts and actions. This proposal examines how these cell types respond to proteotoxic stress associated with neurodegenerative diseases, individually and in collaboration. This information will inform cell-type-specific vulnerabilities in neurodegenerative disease and enable more specific strategies to mitigate neuronal dysfunction and death.

PI_NAMEs: MADAY, SANDRA L. (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: age related neurodegeneration;Age related pathologies;alpha synuclein;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Antioxidants;Astrocytes;Autophagocytosis;Biochemistry;Biogenesis;biological adaptation to stress;Brain;brain cell;cell type;Cellular biology;Coculture Techniques;Collaborations;Couples;Coupling;Data;Disease;Goals;Health;Hippocampus;Homeostasis;Huntington Disease;in vivo;Individual;Inflammation;Inflammatory;knock-down;Knowledge;live cell imaging;Lysosomes;Measures;Mediating;misfolded protein;Modeling;Molecular;Morphology;multicatalytic endopeptidase complex;Nervous System;Neurodegenerative Disorders;neuroinflammation;neuron development;neuron loss;Neuronal Dysfunction;Neurons;neuroprotection;NF-kappa B;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Play;pre-formed fibril;Process;Property;protein aggregation;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;Quality Control;receptor;Regulation;repaired;Resistance;Resolution;response;Role;Rupture;Signal Transduction;spatiotemporal;Stress;synucleinopathy;System;targeted treatment;Testing;TFE3 gene;Thinking;Ubiquitin

PROJECT_TITLE: Astrocyte-neuron regulation of autophagy and lysosomal pathways in proteotoxic stress associated with alpha-synucleinopathies

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The Texas Developmental Center for AIDS Research (Texas D-CFAR) will facilitate collaborative and multidisciplinary HIV research. The Texas D-CFAR will align with NIH HIV research priorities to foster synergy, promote efficiency, and support coordinated research between its home institutions - Baylor College of Medicine (Houston), University of Texas Health Science Center at Houston, and the Texas Biomedical Research Institute (San Antonio). The Texas D-CFAR will build research capacity to achieve its goal: End HIV and Optimizing Health in Texas.

PI_NAMEs: GIORDANO, THOMAS P (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Area;Award;Basic Science;Biomedical Research;Biometry;Biostatistics Core;California;career;Caring;Censuses;Clinical;Clinical Trials;Collaborations;college;combat;Communication;community advisory board;Community Outreach;coronavirus pandemic;Coupled;Data;Development;Diagnosis;Environment;Epidemic;Event;federal policy;Fostering;Funding;Funding Opportunities;Goals;Health;health determinants;Health Insurance;Health Sciences;Health Services;HIV;HIV diagnosis;HIV Infections;Home;Human Resources;improved;innovation;Institution;Knowledge;Leadership;Learning;Medicaid;Medicine;member;Mentors;Mission;multidisciplinary;Newly Diagnosed;next generation;nonhuman primate;novel coronavirus;Occupational activity of managing finances;Outcome;Persons;Pilot Projects;Policies;Population;prevent;Prevention;Procedures;Process;programs;Public Health;Research;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Project Grants;Resource-limited setting;Resources;Risk;Scientist;Services;Strategic Planning;substance use;symposium;synergism;Texas;Training;transmission process;Treatment outcome;United States;United States National Institutes of Health;Universities;US State;Viral;virology;working group


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

PHR: OVERALL: NARRATIVE Benign prostatic hyperplasi is one of the most common symptomatic conditions in aging men, resulting in millions of medical consultations, high healthcare expenditure and loss of productivity. This Center assembles a team of three Early Stage Investigators with expertise in benign urology, inflammation and bioinformatics to pursue a Project to identify the similarities and differences between mouse models of BPH and the human disease, establishing the most appropriate platforms on which to develop and test new medical strategies. The progress of the research, the career development of the team, grant applications derived from the project and data dissemination to the broader research community will be supported by the Administrative Core.

PI_NAMEs: HAYWARD, SIMON W (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Advisory Committees;Age;Aging;Anatomy;Animal Model;Applications Grants;associated symptom;Autoimmune;autoinflammatory;Benchmarking;Benign;Benign Prostatic Hypertrophy;Bioinformatics;Biomedical Research;career;career development;Cells;Charge;Chronic;Collaborations;Collection;Communication;Communities;Comparative Pathology;Complex;Consultations;Critiques;Data;data dissemination;Data Set;data submission;Databases;Development;Discipline;Disease;Disparity;Environment;Epithelium;Exposure to;Feedback;Fostering;Funding;Genetically Engineered Mouse;Goals;Grant;Health Expenditures;Histologic;Human;human disease;Immune;in vivo Model;Individual;Inflammation;interest;Knowledge;knowledge base;Lobe;Manuscripts;Medical;meetings;member;men;method development;Methods;Modeling;Molecular;Molecular Analysis;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel strategies;Output;Paper;Pathologic;Phenotype;Population;productivity loss;program dissemination;Proliferating;Prostate;Prostatic;Prostatic hypertrophy;public database;Publications;Reading;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Rodent;Sampling;single-cell RNA sequencing;skills;success;Testing;Training;transcriptomics;urinary;urologic;Urology;videoconference;Videoconferencing

PROJECT_TITLE: Validating Mouse Models of Prostatic Hyperplasia

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-M (M2)]


NIH_SPENDING_CATS: Urologic Diseases

PROJECT_TERMS: Address;Applications Grants;Benign;Benign Prostatic Hypertrophy;Biology;career;career development;Characteristics;Clinical;Communication;Communities;Data;data repository;Databases;Dedications;Deposition;Development;Documentation;Ensure;experience;Funding;Goals;Histologic;Human;human disease;human tissue;Hyperplasia;IACUC;Individual;Inflammation;insight;Knowledge;Legal;Location;meetings;Mentors;Modeling;Molecular;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;Online Systems;Patients;Persons;Process;Prostate;Prostatic hypertrophy;Publications;Recording of previous events;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;Resources;Running;Sampling;Schedule;single-cell RNA sequencing;skills;Societies;Standardization;Tissue Sample;transcriptomics;Update;urologic;Urology;Videoconferencing;Work


PI_NAMEs: VICKMAN, RENEE E. (contact)

PROJECT_TERMS: Affect;aged;Aging;aspirate;Autoimmune;Autoimmune Diseases;Autoimmune Responses;B-cell receptor repertoire sequencing;Benchmarking;Benign;Benign Prostatic Hypertrophy;Bioinformatics;career;Cell Communication;Cell Physiology;cell type;Cells;Chronic;Clinical;Collection;Communities;comparative;Complex;cost;Coupled;Data;Data Set;Databases;Development;Diagnosis;Diffusion;Environment;Epithelial Cells;Etiology;Evaluation;experience;Failure;Future;Grant;Growth;High Fat Diet;Histologic;Histopathology;Hormone imbalance;Hormones;Human;human disease;human tissue;Hyperplasia;Immune;improved;Individual;Inflammation;Inflammatory;Interdisciplinary Study;Knowledge;Link;Lobe;lower urinary tract symptoms;Lymphocyte;Macrophage;male;Measures;Medical;Medical Care Costs;member;Modeling;Molecular;Morbidity - disease rate;mouse model;multidisciplinary;Mus;Nature;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Permeability;Phenotype;Population;preclinical study;Process;Productivity;Proliferating;Prostate;Prostatic;Prostatic Epithelium;Prostatic hypertrophy;Regulon;Research;Research Personnel;Research Project Grants;Resources;Role;searchable database;Signal Pathway;single-cell RNA sequencing;steroid hormone;Stromal Cells;Symptoms;T-Lymphocyte;therapeutic target;Tissues;transcription factor;transcriptome;transcriptomics;translational model;urinary;urologic;V(D)J Recombination;web app;Work


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: CHEMISTRY

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative The formation of α-syn aggregation, called amyloid fibrils, is known to cause numerous neurodegenerative diseases, collectively referred to as synucleinopathies. Given its implication in the disease-specific spreading of α-syn pathology in synucleinopathies, it is of critical importance to understand how distinct forms of α-syn fibrils are observed despite their structural diversity. To fill this knowledge gap, this proposal seeks to elucidate the molecular interactions between polymorphic α-syn fibrils and diverse cellular factors in microengineered brain tissue, which will provide the structural insights into the development of disease-specific aggregation inhibitors and antibodies based on the structural specificities.

PI_NAMEs: LEE, MYUNGWOON  (contact);PAEK, JUNGWOOK

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 3-Dimensional;Advanced Development;Affect;alpha synuclein;Amyloid Fibrils;Antibodies;Appearance;Architecture;Astrocytes;Binding;Biological;Biological Models;biophysical techniques;Biophysics;Brain;brain cell;Brain region;brain tissue;cell type;Cells;Cellular Membrane;cerebral vascularization;Cerebrovascular system;Classification;Clinical;clinical diagnosis;Coculture Techniques;Complex;Cryoelectron Microscopy;Cytoplasmic Inclusion;design;Development;Diagnostic;Disease;Disease Progression;dopaminergic neuron;Drug Screening;Engineering;Environment;Etiology;Exhibits;Foundations;Genetic Polymorphism;Goals;Heterogeneity;Human;human induced pluripotent stem cells;inhibitor;insight;interdisciplinary approach;interdisciplinary collaboration;Knowledge;Lewy Body Dementia;Link;Lipid Bilayers;Lipids;Mediating;Membrane;Membrane Fusion;membrane model;Methodology;Midbrain structure;misfolded protein;Modeling;Molecular;Molecular Biology;Molecular Conformation;Molecular Profiling;Molecular Structure;Multiple System Atrophy;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;neurotoxic;novel;Organ;organ on a chip;Organelles;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pharmacologic Substance;Physiological;Polymorph;Predisposition;Production;Property;Public Health;Research;response;small molecule;solid state nuclear magnetic resonance;Specificity;Structure;Symptoms;synucleinopathy;Techniques;Technology;Testing;Therapeutic;therapeutic target;three dimensional cell culture;Tissue Engineering;Tissues;Variant;Vascularization

PROJECT_TITLE: Investigating the interplay between polymorphic α-syn fibril conformation and cell-dependent pathology

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_CITY: ALBUQUERQUE

ORG_NAME: LOVELACE BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: NM

PHR: In transcranial electrical stimulation (tES), two electrodes are placed on the head, and weak electric currents non-invasively stimulate the human brain. This project will define how two types of tES (alternate current and direct current stimulations, namely tACS and tDCS) affect not only neurons but cells of the brain microvasculature. Understanding the cellular targets of tES is essential for the rational design of this technique.

PI_NAMEs: BRAGINA, OLGA A (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Action Potentials;Affect;Anesthesia procedures;arteriole;Astrocytes;awake;Behavior;Biological Markers;Biophysics;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;brain cell;Brain Diseases;Brain-Derived Neurotrophic Factor;Cells;cellular targeting;Cephalic;cerebral microvasculature;cerebrovascular;Cerebrovascular Circulation;Cerebrum;Circulation;Clinical Research;Cognition;Complex;Dendrites;design;Dose;Electric Stimulation;Electrodes;Endothelium;Exclusion;Foundations;Frequencies;Head;Homeostasis;Human;in vivo;in vivo imaging;Individual;inhibitor;innovation;Investigation;Journals;Knock-out;Knockout Mice;Laser Scanning Microscopy;Link;Location;locus ceruleus structure;Medical;Membrane;Membrane Potentials;Microcirculation;Modality;Molecular;multi-photon;Mus;Neuroglia;Neurons;neuroregulation;neurovascular coupling;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;novel;Oxygen;Pathway interactions;Performance;Perfusion;Phase;Physiological;practical application;pre-clinical;preclinical study;Probability;rate of change;rational design;Reporting;Research;response;Scalp structure;Science;Synaptic plasticity;Techniques;Testing;Time;Tissues;transcranial direct current stimulation;Translational Research;two photon microscopy;Validation;Vascular Endothelium;Vasodilation;voltage;Work

PROJECT_TITLE: The mechanisms of cerebral microcirculation response to transcranial stimulation.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Neurosciences;Nutrition;Sleep Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: NARRATIVE This study will investigate a new mechanism for Ulcerative Colitis (UC). UC is an inflammatory intestinal disease that affects almost 1 million Americans and the cause of it is unknown. Circadian rhythms are 24h rhythms in our bodies that control many important processes like sleep, eating, inflammation and our immune system. When these circadian rhythms in our body become disrupted it can cause inflammation and disease. This study will test, for the first time, if circadian rhythm disruption is an important part of what causes inflammation in UC and could result in new treatments for UC based on correcting disrupted circadian rhythms in UC patients.

PI_NAMEs: SWANSON, GARTH R (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affect;Alcohols;American;Animal Model;Apical;Behavioral;Biological Process;Brain;Cell Line;Chronic;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Colitis;Colon;Colon Carcinoma;Colonic inflammation;Communities;Complex;Crohn's disease;cytokine;Darkness;Data;design;Diabetes Mellitus;Digestive System Disorders;Disease;disorder risk;dysbiosis;Eating;Endoscopy;Environment;Epithelial Cells;Exhibits;Exposure to;Fasting;Feces;feeding;Flare;Flexible fiberoptic sigmoidoscopy;Future;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;Goals;gut microbiota;Homeostasis;Hour;Human;human subject;immune function;Immune system;in vitro Model;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;Interleukin-6;Intervention;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestines;Irritable Bowel Syndrome;Jet Lag Syndrome;Laboratories;Left;Leukocyte L1 Antigen Complex;Light;Measures;Melatonin;melatonin supplementation;Messenger RNA;Metabolic;Metabolism;metabolomics;microbial community;microbial composition;microbial products;microbiota composition;Modeling;Modernization;Molecular;Molecular Profiling;Molecular Target;monolayer;mortality;mouse model;Mucositis;Mucous Membrane;Occupations;Organ;Organoids;Pathogenesis;Pathway interactions;Patients;Peptic Ulcer;Peripheral;Peripheral Blood Mononuclear Cell;Permeability;Phase;Phototherapy;Predisposition;Prevalence;prevent;Process;Production;prospective;protein complex;Proteins;Protocols documentation;repaired;Research;resilience;Rest;Rodent;Role;Sampling;Serum;Severities;shift work;Shotguns;Side;Sleep;Sleep disturbances;sleep onset;Sleep Wake Cycle;Societies;Structure;systemic barrier;Testing;Tight Junctions;Time;Tissues;TNF gene;Toll-like receptors;transcriptome sequencing;Travel;Ulcerative Colitis;Volatile Fatty Acids

PROJECT_TITLE: The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Schizophrenia is a neuropsychiatric disorder that affects approximately 1% of the population worldwide, with a significant global public health burden; it can exact a devastating toll on patients who suffer from the illness, their families and loved ones. Through the use of cutting-edge genomics tools and resources, the current project will investigate a specific class of variant, "tandem repeat variation", that may increase schizophrenia risk. The project may thereby elucidate an aspect of the biology of schizophrenia, novel genetic risk factors, with consequent translational implications, paving the path for improved schizophrenia diagnosis and treatment strategies.

PI_NAMEs: BIRNBAUM, REBECCA  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Accounting;Affect;Algorithms;Autopsy;Base Sequence;Bioinformatics;Biological Assay;Biology;Brain;brain based;Categories;cohort;comparison control;Complex;Copy Number Polymorphism;Data;Data Set;Diagnosis;Disease;disorder risk;Exhibits;exome sequencing;Family;Frequencies;Future;Genetic;Genetic Polymorphism;Genetic Risk;genetic risk factor;genetic variant;Genome;genome resource;genome wide association study;genome-wide;genomic tools;Genomics;Genotype;Goals;Heritability;human disease;Huntington Disease;improved;innovation;insight;Investigation;Length;Linkage Disequilibrium;loved ones;Maps;Mendelian disorder;Mental disorders;Minisatellite Repeats;Mutation;Nervous System Disorder;Neurologic;neuropsychiatric disorder;next generation;next generation sequencing;novel;Nucleotides;Pathogenicity;Patients;peripheral blood;Population;Public Health;rare variant;Reporting;risk variant;Role;Sampling;Schizophrenia;schizophrenia risk;Short Tandem Repeat;Single Nucleotide Polymorphism;Spinocerebellar Ataxias;Structure;Tandem Repeat Sequences;Testing;tool;translational approach;treatment strategy;Trinucleotide Repeats;Variant;whole genome

PROJECT_TITLE: An Investigation of Tandem Repeat Variation in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: PROJECT NARRATIVE There are no FDA-approved medications available to prevent preterm delivery of an underdeveloped fetus. The research planned in this application will employ tissues from pregnant women to explore novel signaling pathways that explain the dysfunction of preterm labor that leads to preterm birth. The goal of this supplement is to perform basic, translational research to provide data in support of a full application that will advance our understanding of underlying mechanisms of drug action to discover novel therapeutics that provide more effective treatment for pregnant women.

PI_NAMEs: BAKER, JONATHAN E. (contact)

PROGRAM_OFFICER_NAME: NANDA, JAGPREET SINGH

PROJECT_TERMS: Acute;Administrative Supplement;Affect;African American population;Agonist;Animal Model;Area;Automobile Driving;Award;Biomedical Research;Birth;Blood flow;Calcium;Cell Compartmentation;Centers of Research Excellence;Clinical;Cyclic AMP;Cyclic GMP;Data;Development;Differentiation and Growth;disability;disability risk;Discipline of obstetrics;Disparate;Dose Limiting;drug action;effective therapy;Endothelial Cells;Endothelium;Ethnic Origin;FDA approved;Fetal Development;Fetus;Functional disorder;Funding;Future;Generations;Goals;Grant;health disparity;High Risk Woman;Human;improved;in utero;individualized medicine;interest;Interruption;Knowledge;Maintenance;Mechanics;Mediating;medical schools;Membrane;Metabolism;Mothers;Muscle Cells;Muscle relaxation phase;Myometrial;myometrium;National Institute of Child Health and Human Development;Nevada;Nifedipine;Nitric Oxide;Nitric Oxide Donors;Nitrosation;novel;novel therapeutic intervention;novel therapeutics;Outcomes Research;overexpression;Oxidoreductase;Pathway interactions;Patients;Pharmaceutical Preparations;Piezo 1 ion channel;Potassium;Potassium Channel;potassium channel protein TREK-1;pre-clinical;Preclinical Testing;Pregnancy;pregnant;Pregnant Uterus;Pregnant Women;Premature Birth;Premature Labor;prevent;Production;programs;Protein Kinase;receptor;Regulation;Relaxation;Research;Research Infrastructure;Research Project Grants;Research Support;Research Training;respiratory smooth muscle;Risk;S-Nitrosoglutathione;Services;Signal Pathway;Signal Transduction;small molecule;Smooth Muscle;Smooth Muscle Myocytes;Stretching;Terbutaline;Testing;Time;Tissues;Tocolysis;Tocolytic Agents;Training;Translational Research;undergraduate research;United States National Institutes of Health;Universities;uterine smooth muscle cell;Uterus;Vascular Endothelial Cell;Vascular Endothelium;Vascular Smooth Muscle;Women's Health;women's outcomes;women's reproductive health;Work;Workforce Development

PROJECT_TITLE: Nevada IDeA Networks of Biomedical Research Excellence (INBRE) Women's Health Administrative Supplement


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: BURLINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Muscles that move our bodies do so through interactions between the thin and thick protein filaments from which muscles are built. Myosin-binding protein C (MyBP-C) is a thick filament component that helps regulate muscle contraction, and genetic defects in MyBP-C are a cause of skeletal muscle diseases. In this project we will use zebrafish as a model system in conjunction with sophisticated microscopy and other techniques to reveal how MyBP-C functions, providing new insights into the molecular mechanisms by which skeletal muscle contraction is regulated.

PI_NAMEs: WARSHAW, DAVID M (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Actomyosin;Affect;Alleles;Arthrogryposis;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Models;biophysical analysis;Biophysics;C-terminal;Calcium;Complement;Consumption;CRISPR/Cas technology;Data;design;Disease;Distal;DNA cassette;DNA Sequence Alteration;Family member;Fertilization;Fiber;Filament;Fishes;Future;gene editing technology;Gene Modified;Generations;Genes;genomic locus;Goals;Head;Health;high reward;high risk;Human;Immunofluorescence Immunologic;Immunofluorescence Microscopy;In Vitro;in vivo;Individual;insight;Interruption;Link;Mammals;Mass Spectrum Analysis;Measures;Mechanics;Mediating;Methods;Microfilaments;Microscopy;model organism;Modeling;Molecular;Molecular Structure;Monitor;Motion;Muscle;Muscle Contraction;muscle physiology;Muscle Proteins;muscular system;Mutation;Myofibrils;Myopathy;Myosin ATPase;myosin-binding protein C;N-terminal;Nonmuscle Myosin Type IIA;novel strategies;Organism;Orthologous Gene;Physiological;Physiology;Protein Isoforms;Proteins;Proteomics;Relaxation;Role;Sarcomeres;single molecule;skeletal;Skeletal Muscle;Skeletal Muscle Myosins;Slide;Slow-Twitch Muscle Fibers;Striated Muscles;Structure;Swimming;Tail;Techniques;Therapeutic;Thick;Thick Filament;Thin Filament;Thinness;transgene expression;Transgenes;Transgenic Organisms;Variant;Zebrafish

PROJECT_TITLE: Skeletal Myosin-Binding Protein C: Defining Function Across Scales Using a Zebrafish Model System.

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ORG_CITY: NORTH CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

PHR: Homeostatic plasticity is increasingly recognized as a major driving factor in the pathophysiology of numerous neurological, psychiatric, and neurodevelopmental disorders and conditions. Our study on the homeostatic regulatory mechanism of the CaV2 voltage-gated calcium channel abundance will enhance our understanding of pathophysiologies of those brain disorders and pave the way for innovative therapeutic strategies.

PI_NAMEs: KIM, HONGKYUN  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Affect;Alzheimer's Disease;Animals;Automobile Driving;Brain Diseases;Bypass;Caenorhabditis elegans;Calcium Channel;Calibration;Cell membrane;chemical genetics;Coupling;CRISPR/Cas technology;Data;Defect;Drug Targeting;Ensure;environmental stressor;Excision;Exocytosis;Feedback;Fragile X Syndrome;Functional disorder;Genetic;genetic approach;Genetic Models;Heart;Impairment;innovation;loss of function;loss of function mutation;Mammals;Measures;Mechanics;Mental Depression;Mental disorders;model organism;mutant;Mutation;Nematoda;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;Neurons;neurotransmitter release;novel;operation;optogenetics;Pattern;postsynaptic;preservation;presynaptic;presynaptic neurons;Presynaptic Terminals;Probability;Proteins;receptor function;Regulation;response;Role;scale up;Signal Transduction;SNAP receptor;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;Synaptic Vesicles;syntaxin;Testing;Therapeutic;tool;UNC13B gene;voltage

PROJECT_TITLE: Homeostatic regulation of CaV2 voltage-gated calcium channels at synapses

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Microbiome;Nutrition;Precision Medicine;Prevention;Radiation Oncology;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE  We will investigate whether the pre- and post-systemic treatments gut microbiome affect breast cancer outcomes (recurrence and mortality) and evaluate whether changes in the gut microbiome, particularly cancer treatment-related dysbiosis persist after the completion of cancer therapy. Results from this study will be valuable in developing interventions to optimize the pre-treatment gut microbiota and attenuate dysbiosis during and after cancer treatment with an optimal goal of promoting health and reducing recurrence risk among breast cancer survivors.

PI_NAMEs: NGUYEN, SANG MINH (contact);SHU, XIAO-OU

PROGRAM_OFFICER_NAME: RISCUTA, GABRIELA

PROJECT_TERMS: Address;Affect;African American;Aftercare;Age;Antibiotic Therapy;Antibiotics;Attenuated;Bacteria;Bacterial Translocation;Body mass index;Breast Cancer Patient;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer survivor;Breast Cancer survivorship;Breast Cancer Treatment;cancer care;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancer Prognosis;cancer recurrence;Cancer Survivorship;cancer therapy;Cardiovascular system;chemotherapy;Collection;comorbidity;Country;cytotoxicity;Data;Development;Diagnosis;Dietary intake;Drug Modulation;dysbiosis;experience;Feces;Foundations;frontier;Goals;gut dysbiosis;gut microbiome;gut microbiota;Health;Health Promotion;Homeostasis;Human;immunoregulation;improved;indexing;Inflammatory;Intervention;Knowledge;Linear Regressions;low and middle-income countries;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Menopausal Status;Metabolic;Metabolic Pathway;metagenomic sequencing;microbial;microbiome;microbiome therapeutics;Modeling;molecular subtypes;mortality;Mucous body substance;novel;Outcome;Participant;Patients;personalized medicine;Physical activity;Pilot Projects;pilot test;Play;precision medicine;prevent;Prognostic Factor;Quality of life;Radiation;Radiation therapy;Recurrence;Research;response;Risk;Role;Shotguns;stool sample;Survivors;therapy development;Time;Toxic effect;Treatment Efficacy;treatment response;Treatment-Related Cancer;Vietnam;Volatile Fatty Acids;Woman;Women's mortality

PROJECT_TITLE: Gut Microbiome Profiles in Association with Breast Cancer Recurrence and Mortality

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative Existing clinical trial data provide many opportunities for analysis after the primary study is completed, especially considering the funding, the time, and the commitment of the study participants that went into generating the data. This proposal will enhance the reusability of clinical study data by simplifying the annotation of laboratory- based clinical trial data for integration into the Immunology Database and Analysis Portal (ImmPort) database and creating a user-friendly tutorial. This focus on re-use of clinical study data shared through ImmPort will maximize the return on investment for biomedical research with significant implications for scientific knowledge and clinical care.

PI_NAMEs: ANDORF, SANDRA  (contact)

PROGRAM_OFFICER_NAME: LIN, DAWEI

PROJECT_TERMS: Address;Biomedical Research;Clinical;clinical care;Clinical Data;Clinical Research;Clinical Study Element;clinical trial analysis;Clinical Trials;Community Outreach;Complex;computerized data processing;Custom;Data;data and analysis portal;data curation;data dictionary;Data Files;data integration;data modeling;data resource;data reuse;Data Set;data sharing;Data Storage and Retrieval;data submission;Database and Analysis Portal;database structure;Databases;Disparate;Educational process of instructing;Ensure;FAIR principles;file format;Food Hypersensitivity;Funding;Future;Goals;graphical user interface;Immunologics;Immunology;improved;Individual;Informatics;Ingestion;innovation;Investments;Knowledge;Laboratories;Manuals;Molecular;National Institute of Allergy and Infectious Disease;Participant;Performance;Phenotype;prevent;Process;Protocols documentation;prototype;Pythons;Reporting;Reproducibility;Research Design;Research Personnel;secondary analysis;Shapes;shared database;sharing platform;Structure;structured data;Test Result;Testing;Time;tool;United States National Institutes of Health;user-friendly;Visualization;Work

PROJECT_TITLE: Simplifying the transformation of laboratory test data for integration into the ImmPort database

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROLOGY

PHR: This research education program is designed to lead residents in neurology to become outstanding clinician-scientists who will become the next world leaders in discovering how to improve diagnosis, and treatment of neurological disease. It is also aimed to refine the mentoring skills of emerging leaders in the field, so that they can continue this mission in the future.

PI_NAMEs: HILLIS, ARGYE E. (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Brain;cellular engineering;Clinical;Clinical and Translational Science Awards;design;Diagnosis;Discipline;education research;education resources;Educational process of instructing;Environment;Evaluation;Faculty;Feedback;Fellowship;Functional Imaging;Funding;Future;Grant;imaging facilities;improved;Investigation;Lead;medical schools;Mentors;Mind;Minority;Mission;Nervous System Disorder;Nervous System Physiology;neurological recovery;Neurology;Neurosciences Research;next generation;Participant;Patient Recruitments;Positioning Attribute;programs;Public Health Schools;Research;Residencies;Resources;role model;Science;Scientist;skills;skills training;Structure;Talents;Time;Training;Woman

PROJECT_TITLE: Research Education Program for Residents and Fellows in Neurology - Porras


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Genetics;Neurosciences

ORG_CITY: BETHLEHEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: LEHIGH UNIVERSITY

PHR: PROJECT NARATIVE Despite its prevalence, ME/CFS remains a poorly understood disease that lacks lab-based, objective diagnostic markers. We propose to study the gene expression, function and electrical property of donor derived, proliferative adult skeletal muscle mononucleated cells (SMMCs). The resulting electrical characteristics coupled with single cell genetic and biological studies have a potential to identify pathology and biomarkers in these cells for future development of ME/CFS diagnostics.

PI_NAMEs: CHENG, XUANHONG  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Adult;Affect;American;Biological;Biological Markers;biomarker identification;biophysical techniques;Biophysics;Biopsy Specimen;Biosensing Techniques;Cell Physiology;Cell Separation;cell type;Cells;Characteristics;Chronic Fatigue Syndrome;Clinical;Complex;Convalescence;Coupled;Coupling;COVID-19 pandemic;COVID-19 patient;Cytometry;Development;Diagnosis;Diagnostic;diagnostic biomarker;diagnostic development;Disease;disease diagnosis;electric impedance;electrical property;Etiology;Evaluation;Exclusion;Exertion;experience;Fatigue;Functional disorder;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic;Genetic Markers;Genetic Transcription;Global Change;Heterogeneity;Impairment;Incidence;Individual;innovation;Investigation;Knowledge;Leukocytes;Life;Machine Learning;machine learning algorithm;Measures;member;Messenger RNA;Methods;Molecular;Molecular Analysis;molecular marker;Muscle;Myopathy;Organelles;Pathologic;Pathology;Pathway interactions;Patients;persistent symptom;Physiology;Prevalence;Procedures;programs;protein expression;Qualifying;Quality Control;Research;RNA;Role;Sampling;sensor;single cell mRNA sequencing;single cell technology;single-cell RNA sequencing;skeletal;Skeletal Muscle;Sorting;Specificity;Subcellular structure;Symptoms;System;Techniques;Testing;Tissue-Specific Gene Expression;transcriptome;Work

PROJECT_TITLE: Transcriptional profiling of proliferative skeletal muscle mononucleated cells coupled with broadband electrical cytometry towards diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CFS-J (80)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE The proprioceptive sense is critical for numerous aspects of motor control as well as for the sense of self. Many decades of work have yielded remarkable progress in our understanding of the sensory neurons involved in this sense and the type of feedback they contribute, yet the role of muscle spindle (MS) group II afferents has remained incompletely understood due to the inability to examine these afferents selectively through physiological or genetic means. Building on our recent findings that MS group II afferents can be distinguished from other proprioceptive muscle afferents by virtue of the expression of Nxph1, this proposal aims to deliver a Nxph1:Cre mouse model to permit a more systematic and selective examination of MS group II afferent function and circuitry.

PI_NAMEs: DE NOOIJ, JORIENE  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Adult;Afferent Neurons;Animal Model;blastocyst;body position;Brain Stem;Cells;Collaborations;Communities;Data;design;Development;Disease;embryonic stem cell;Enterobacteria phage P1 Cre recombinase;experimental study;Family;Feedback;Generations;Genetic;genetic approach;genetic resource;Glycoproteins;Goals;Golgi Tendon Organs;Health;Individual;Joints;Kinesthesis;Knock-in Mouse;Length;limb movement;Limb structure;Measures;Mediator;member;Modeling;Molecular;molecular marker;Morphology;Motor;motor control;mouse model;Mouse Strains;Mus;Muscle;Muscle Spindles;Muscle Tension;neural circuit;neurexophilin;Neurons;novel;Organ;Peripheral;Physiological;Play;Positioning Attribute;postnatal;Property;Proprioception;Proprioceptor;receptor;Reporter;Research;Role;sensor;Sensory;sensory feedback;Signal Transduction;Skeletal Muscle;somatosensory;Spinal;Spinal Cord;Spinal Ganglia;Stimulus;Stretching;tool;transcriptome;Validation;Viral;Work

PROJECT_TITLE: Developing genetic access to group II proprioceptive muscle afferents

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The UW/Fred Hutch Center for AIDS Research (CFAR) is a multi-institutional consortium based in Seattle which catalyzes new HIV research and develops new research leaders across the multidisciplinary spectrum of basic, clinical, epidemiologic, statistical, sociobehavioral, and implementation science expertise necessary to bend the curve of the global HIV epidemic. During 35 years of continuous funding, the UW/Fred Hutch CFAR has facilitated substantial growth in research infrastructure, domestic and international partnerships, research impact, and development of emerging HIV researchers (with a return on investment on CFAR developmental awards of 1767%) with high added value and aided by significant institutional commitment. Through our proposed eight Cores and two Scientific Working Groups, we aim to expand multidisciplinary HIV research that spans bench to bedside to populations and grow new researchers, research leaders, infrastructure, and resources to impact the global epidemic.

PI_NAMEs: CELUM, CONNIE L (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;AIDS prevention;AIDS related cancer;anti-racism;Area;Award;base;Basic Science;Behavior Therapy;Behavioral;Behavioral Sciences;bench to bedside;Biological Markers;Cancer Center;cancer therapy;Cardiovascular system;care outcomes;career;CCR;Child;Chronic;Clinical;Clinical Research;Clinical Sciences;Collaborations;community engaged research;community engagement;community partnership;comorbidity;Complex;Data Analyses;Data Science;design;Development;Diagnosis;Disease;Educational workshop;Environment;Epidemic;Epidemiology;epidemiology study;Equity;equity, diversity, and inclusion;Fostering;Foundations;Funding;Goals;Growth;Hawaii;Health;health disparity;health equity;Hepatic;HIV;HIV Infections;Immunology;implementation facilitation;implementation science;improved;improved outcome;Incentives;Indigenous;Infection;Inflammation;Infrastructure;innovation;insight;Institution;interdisciplinary approach;Interdisciplinary Study;international partnership;Intervention;Investments;Leadership;Lung;marginalized population;member;Mentors;Metabolic;Methamphetamine;Methods;Minority;Mission;multidisciplinary;Neurologic;next generation;novel;Opioid;Outcome;Pathogenesis;Persons;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention strategy;Process;programs;Qualitative Research;Reduce health disparities;Research;Research Design;Research Infrastructure;Research Institute;Research Personnel;Research Priority;Research Support;Resources;Retrovirology;Role;Science;Services;Social Behavior;Strategic Planning;substance use;success;symposium;Testing;Training;Translational Research;Translations;treatment strategy;United States National Institutes of Health;Universities;uptake;Vaccine Design;Washington;working group

PROJECT_TITLE: University of Washington/Fred Hutch Center for AIDS Research


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The drug supply chain is global and susceptible to disruptive unanticipated events, such as the 2019 Corona- virus (COVID-19) pandemic, but the impact of drug shortages during a global public health emergency and effectiveness of strategies to alleviate drug shortages is unknown. The proposed research is relevant to public health because policy-makers need real world evidence to plan for future global emergencies, drug shortages at large, and inform national- and international-policy to decrease the impact of drug shortages on patient outcomes. Thus, this project is relevant to the AHRQ research priority areas of patient safety, im- provements in health care practice, providing timely response to critical questions, and AHRQ priority groups.

PI_NAMEs: SUDA, KJ  (contact)

PROGRAM_OFFICER_NAME: WAGNER, MEGHAN

PROJECT_TITLE: Impact of COVID-19 on Drug Shortages

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


PHR: The proposed research is relevant to public health because it focuses on developing a new and alternative strategy for sensing biomolecules through antigen-antibody interactions using electrochemical single nanoparticle detection. These measurements can potentially advance the detection of disease markers down to a single nanoparticle-bioconjugate, providing an efficient diagnosis before symptoms appear and guiding therapy and isolation decisions. Thus, the proposed research is relevant to the part of the NIH’s mission concerning reducing illness and disability.

PI_NAMEs: ALPUCHE-AVILES, MARIO ALBERTO (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Developing a redox-mediated single NP detection for bioconjugate analysis.

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Most myopia (short-sightedness) represents a failure of emmetropization in which the eye continues to grow after a match between its length and optical power is reached. Myopia’s association with sight-threatening complications and projected near-epidemic levels world-wide (~50% by 2050) makes it critical to develop effective myopia control treatments. This project will apply modern molecular biology and in vivo clinical and optical imaging techniques to better understand an existing drug treatment for controlling myopia and explore new ones, including a novel drug combination.

PI_NAMEs: WILDSOET, CHRISTINE FRANCES (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;Amblyopia;Animal Model;Apomorphine;Atropine;attenuation;Biometry;Blood Vessels;Carbidopa;Cavia;Chick;Chick model;Childhood;Choroid;Ciliary Body;Ciliary Muscle;Circadian Rhythms;Clinical;clinical imaging;Clinical Research;Combined Modality Therapy;Contact Lenses;Data;design;Dopamine;Dopamine Agonists;Drug Kinetics;effective therapy;efficacy evaluation;emmetropization;Epidemic;epidemic response;experience;experimental study;Eye;Eyedrops;Eyeglasses;Failure;Focal Adhesions;follow-up;Gene Expression;Gene Expression Profile;Genes;Glaucoma;Goals;Growth;guinea pig model;Human;Image;Imaging Techniques;improved;in vivo;inhibitor;insight;interest;Intervention;intravitreal injection;Length;lens;Lesion;Levodopa;Measurement;Modeling;Modernization;Molecular Biology;Molecular Biology Techniques;monocular;Morphology;Myopia;Nerve;novel drug combination;ocular imaging;off-label use;optical imaging;Optics;Pathology;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pigment Epithelium;Population;Prevalence;Primates;Reporting;Research;Retina;Risk;Role;Sampling;Sclera;sham surgery;Signal Transduction;Site;statistics;Structure of retinal pigment epithelium;Testing;Therapeutic Effect;Thick;Thinness;Time;tool;Topical application;transcriptome sequencing;translational potential;Translations;treatment arm;treatment comparison;treatment effect;Treatment Efficacy;treatment group;Treatment outcome;Vision;visual processing;young adult

PROJECT_TITLE: Application of an optical defocus model to explore mechanisms underlying myopia and control interventions

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Recent evidence suggests that diminished learning over repeated evaluations (web-based memory tests on the same content for 12min/day for 7 days) reveals subtle AD-related memory decrements otherwise undetectable using traditional single timepoint cognitive testing. Whether this paradigm is similarly sensitive to AD-related cognitive decline in a demographically and geographically diverse population with heightened cerebrovascular risk is unclear; furthermore, it is unclear whether change in an individual’s learning curve, captured biannually, can further improve monitoring of AD-related decline. We will recruit 300 well- characterized cognitively unimpaired older adults with AD biomarkers (amyloid and tau Positron Emission Tomography (PET)) enrolled in the U.S. POINTER study (Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk); we will explore whether a personal learning curve-PLC collected every 6 months for 12 months is a valid and sensitive marker of AD-related decline while also exploring the moderating effects of non-AD related risk (e.g., non-specific neurodegeneration, cerebrovascular risk) in this representative at-risk population (32% from underrepresented ethnical and racial groups, family history of cognitive decline, hypertension, geographic diversity).

PI_NAMEs: PAPP, KATHRYN VICTORIA (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anxiety;Blood Pressure;Boston;brain health;Cardiovascular Diseases;cardiovascular risk factor;cerebrovascular;Clinic;Clinical;Clinical Trials;clinically relevant;Cognitive;cognitive change;cognitive performance;cognitive testing;Dementia;Devices;digital;digital tool;Disease;Early Diagnosis;Educational Psychology;Enrollment;Ensure;ethnic minority population;Ethnic Population;Evaluation;Failure;Familiarity;Family history of;Geography;Health;hippocampal atrophy;Hypertension;Impaired cognition;improved;Individual;Intervention;Learning;lifestyle intervention;Magnetic Resonance Imaging;Measures;Memory;Memory Loss;Methods;mild cognitive impairment;Monitor;Nerve Degeneration;Neurocognitive;novel;older adult;Online Systems;Participant;Patient Recruitments;peer;Performance;Phase;Population;Population Heterogeneity;Populations at Risk;Positron-Emission Tomography;Process;progression risk;racial minority population;racial population;recruit;remote assessment;Research;Resolution;Risk;Risk Reduction;Sampling;Spanish/English;tau Proteins;Testing;tool;treatment response;Validation;web app;White Matter Hyperintensity;Work

PROJECT_TITLE: Early detection & monitoring of memory decline in a representative sample of older adults at risk for Alzheimer's disease and related dementias

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Diabetes;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Mutations in the genes BRCA1 or BRCA2 increase the risk of breast and ovarian cancers, and we have found that having obesity or unhealthy metabolism increases damage to the cells of the breast and fallopian tube that can become cancerous. In mouse models, we discovered that having a mutation in BRCA leads to unhealthy metabolism which may contribute to cancer - this has not been shown before. A first step will be to understand which metabolic tissues are affected and whether this is also true for women, as this could help us understand why some women develop cancer and find ways of reducing their risk.

PI_NAMEs: THYFAULT, JOHN P;WEINMAN, STEVEN A (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Administrative Supplement;Affect;Age;Animal Experimentation;Anti-diabetic Drugs;Aromatase;Award;biobank;Biological Markers;biomarker validation;Biometry;Blood;Body Composition;Body mass index;Body Weight;BRCA mutations;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;Breast;Breast Cancer Risk Factor;Breast Epithelial Cells;C-reactive protein;Calorimetry;cancer risk;Cancerous;cell injury;Cells;Collaborations;comparison control;Core Facility;Crowns;Data;Data Science;Defect;Development;Diagnosis;Diameter;Diet;diet-induced obesity;Discipline;DNA Damage;DNA Double Strand Break;DNA Repair Gene;epidemiology study;Estradiol;Estrogens;Exhibits;experimental group;Fat-Restricted Diet;follow-up;Funding;Gene Mutation;General Population;Genotype;Germ-Line Mutation;Gland;Glucose;glucose tolerance;Grant;Growth;Health;health disparity;Hepatic;Heterozygote;High Fat Diet;Histology;Hypertrophy;Image;immunoreactivity;impaired driving performance;impaired glucose tolerance;Impairment;improved;Individual;Inflammation;innovation;insight;Insulin;Insulin Resistance;Intervention;Kansas;Knockout Mice;Laboratory Animals;Leptin;Link;lipidomics;Lipids;Liver;Liver Fibrosis;Liver Function Tests;Loss of Heterozygosity;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;mammary epithelium;Mammary Gland Parenchyma;Measurement;Menopausal Status;Metabolic;Metabolic dysfunction;Metabolism;Metformin;Mitochondria;mortality;mouse model;Mus;Muscle;Mutation;mutation carrier;novel;novel strategies;Obesity;Operative Surgical Procedures;Ovarian;Ovariectomy;oxidation;Pancreas;Pathogenicity;Pathway interactions;Penetrance;personalized decision;Production;prophylactic;Research;response;Risk;Risk Reduction;Seminal;Serum;Skeletal Muscle;standard of care;Structure;Testing;Thinness;Tissue Banks;Tissues;treatment response;tumor;Wild Type Mouse;Woman;Women's study;Work

PROJECT_TITLE: Kansas Center for Metabolism and Obesity REsearch (KC-MORE)


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to public health because it focuses on the testing of a psychosocial intervention for the management of anxiety among adolescents and young adult cancer survivors. Approximately 50% of adolescent and young adult cancer survivors will experience clinically significant anxiety in the months to years following cancer treatment. The results are expected to have a positive impact because demonstration that virtual tailored, music-based relaxation is feasible to implement among adolescent and young adult cancer survivors will inform the design of a Phase II clinical trial to demonstrate efficacy of the intervention for anxiety, a distressing side effect of cancer treatment for which little is known about how to best support the psychosocial needs of adolescent and young adult cancer survivors.

PI_NAMEs: KNOERL, ROBERT JAMES (contact)

PROGRAM_OFFICER_NAME: SAMIMI, GOLI

PROJECT_TERMS: Achievement;Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;Adult;Aftercare;Anxiety;Anxiety Disorders;anxiety management;anxiety reduction;anxiety treatment;arm;attentional control;Board Certification;cancer initiation;Cancer Patient;cancer recurrence;Cancer Survivor;Cancer Survivorship;cancer therapy;Clinical;clinically relevant;clinically significant;Cognitive Therapy;comparison group;Control Groups;coping;Data;design;Development;Diagnosis;Distress;Dose;effective intervention;efficacy evaluation;efficacy trial;Eligibility Determination;Ensure;Evidence based treatment;experience;Fatigue;follow-up;Fright;Future;Growth;Guidelines;Healthcare;improved;Individual;Intervention;intervention delivery;Intervention Trial;Interview;Knowledge;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mental disorders;Methods;Michigan;Music;Music Therapy;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Phase;Phase II Clinical Trials;phase II trial;Pilot Projects;post intervention;Protocols documentation;psychosocial;Psychosocial Assessment and Care;Psychotherapy;Public Health;quality assurance;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Relaxation;Reporting;Research;Resources;Schools;Self Efficacy;Self Perception;side effect;Sleep Disorders;social media;social stigma;Specificity;Standardization;Structure;Testing;theories;Treatment Efficacy;Universities;virtual;virtual delivery;Work

PROJECT_TITLE: Determining the Feasibility of Virtual Tailored, Music-Based Relaxation for Anxiety Among Adolescent and Young Adult Cancer Survivors.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (M1)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Lung;Orphan Drug;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

PHR: Macrophages are white blood cells that function as the front line of defense against many infectious microbes. An in-depth understanding of how macrophages sense and respond to viral pathogens, and specifically, Respiratory Syncytial Virus (RSV) and influenza, is the goal of this project. Our research findings can be expected to lead to identification of new therapeutic treatments that will increase the capacity of macrophages to prevent or repair damage to tissues caused by viral infection, and thereby promote survival of infected people.

PI_NAMEs: BLANCO, JORGE C (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acceleration;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adoptive Transfer;Agonist;Anti-diabetic Drugs;Anti-Inflammatory Agents;arginase;Attenuated;Binding;Binding Sites;Cell Physiology;Cessation of life;Clinical;conditional knockout;Cotton Rats;cyclooxygenase 2;Cytokine Gene;cytokine release syndrome;Development;Dinoprostone;Effectiveness;efficacious treatment;efficacy evaluation;Equilibrium;Exhibits;experimental study;Family;Family member;Gene Expression;Genes;genetic corepressor;Genetic Transcription;Goals;Human;Immune response;In Vitro;in vivo;Inflammation Mediators;Inflammatory;Influenza;influenza infection;Innate Immune Response;Interleukin-13;Interleukin-4;Intervention;Knockout Mice;Laboratories;Lead;Leukocytes;Ligands;Lower Respiratory Tract Infection;Lung;Lung Diseases;lung injury;Macrophage;Mediating;Mediator;member;Messenger RNA;Microbe;microbicide;Modeling;Molecular;Mus;Myeloid Cells;Nervous System Disorder;novel therapeutics;Nuclear Hormone Receptors;pathogen;pathogenic virus;Persons;pharmacologic;Phenotype;Pioglitazone;Play;PPAR gamma;Predisposition;prevent;Production;promoter;Prostaglandin Receptor;Proteins;prototype;Publishing;Pulmonary Inflammation;Pulmonary Pathology;receptor;recruit;Regulation;repaired;Research;Resistance;Resolution;respiratory;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;respiratory virus;response;Rodent;Rodent Model;Role;rosiglitazone;RXR;screening;Sigmodon;synergism;Testing;Therapeutic;Therapeutic Effect;Therapeutic Uses;Tissues;transcription factor;Treatment Efficacy;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;WFDC2 gene;Wild Type Mouse;Work

PROJECT_TITLE: RXR/PPARg heterodimer agonists for treating virus-induced acute lung injury

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Although the importance of astrocyte energy metabolism in supporting synaptic neurotransmission and synaptic plasticity has been demonstrated, there is no data of the contribution of astrocyte energy metabolism to opiate-induced plasticity. We propose to investigate a role for astrocyte mitochondria oxidative phosphorylation in heroin-induced plasticity.

PI_NAMEs: DIETZ, DAVID M;PLETNIKOV, MIKHAIL V (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Abstinence;addiction;Area;Astrocytes;Behavior;Behavioral Paradigm;Bioenergetics;Biological Assay;Brain;Cells;Chronic;comparison control;complex IV;conditional knockout;Control Animal;Cues;Data;drug seeking behavior;Energy Metabolism;Energy Metabolism Pathway;Environment;Event;Exhibits;experience;experimental study;Exposure to;extracellular;Future;Genes;Glutamates;Heme;heme O;Heroin;heroin use;innovation;Intake;knock-down;Knockout Mice;long term abstinence;Mediating;Metabolic;Metabolic Pathway;metabolomics;Methodology;Mitochondria;Mitochondrial Proteins;Molecular;Morphine;Morphology;Mus;Mutant Strains Mice;Naloxone;Nervous System;neuroadaptation;Neurobiology;Neuroglia;neuroinflammation;Neurons;neurotransmission;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Receptor;opioid use disorder;Oxidative Phosphorylation;Pharmaceutical Preparations;Physiological;programs;prolonged abstinence;protein farnesyltransferase;receptor;Relapse;Research;Respiration;Role;Self Administration;Signal Pathway;Synapses;Synaptic plasticity;Testing;Up-Regulation;Wild Type Mouse;Withdrawal

PROJECT_TITLE: Astrocyte energy metabolism in opiate use disorders

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Overall The DC CFAR's mission is to intensify our multi-institutional effort to promote and support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. The CFAR achieves this mission by providing scientific and administrative leadership to advance HIV research among the eight collaborating DC CFAR institutions; stimulating and supporting innovative and consequential HIV research in the basic, clinical, prevention and social and behavioral sciences; driving the development and recruitment of early stage, new, and women and underrepresented minority HIV investigators; and enhancing communication and fostering meaningful new collaborations between DC CFAR investigators and academic, government, community and clinical partners.

PI_NAMEs: GREENBERG, ALAN EDWARD (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Adult;AIDS prevention;American;Area;Articulation;Automobile Driving;Award;base;Basic Science;Behavioral Sciences;black men;Capital;Child;Cities;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engagement;comorbidity;Consultations;design;Development;District of Columbia;Epidemic;epidemic response;Evaluation;Fostering;Foundations;Funding;Future;Government;Grant;Growth;Health;health data;health inequalities;Health system;high risk;HIV;HIV diagnosis;implementation science;Infrastructure;innovation;Institution;interdisciplinary approach;Investments;Lead;Leadership;Manuscripts;Medical center;meetings;Mentors;Mission;Modeling;multidisciplinary;Newly Diagnosed;Population Sciences;Positioning Attribute;pre-exposure prophylaxis;Prevention;programs;Public Health;Publishing;recruit;Reporting;Research;Research Activity;Research Personnel;Research Support;response;scale up;Science;Services;Site Visit;Social Sciences;Underrepresented Minority;United States Department of Veterans Affairs;United States National Institutes of Health;Universities;Update;Vision;Washington;webinar;Woman;working group

PROJECT_TITLE: District of Columbia Center for AIDS Research


NIH_SPENDING_CATS: Diabetes;Digestive Diseases;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Many people with diabetes and obesity suffer from gastrointestinal complications. Herein, the candidate has discovered that diabetes and obesity drastically alters stomach tissue. This grant will determine specifically how stomach cells are altered with disease and uncover the mechanisms driving these changes.

PI_NAMEs: MCKIMPSON, WENDY MARIE (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Appearance;Applications Grants;Attention;Automobile Driving;Beta Cell;Cell Lineage;Cell Separation;cell type;Cells;Chromogranin A;clinically significant;Crohn's disease;Data;Diabetes Mellitus;Diet;Disease;Disease Progression;Diverticulosis;Endocrine;Enterobacteria phage P1 Cre recombinase;Environment;Enzyme-Linked Immunosorbent Assay;experience;feeding;Functional disorder;Funding;gain of function;gamma secretase;Gastroesophageal reflux disease;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Gene Expression;Genetic Transcription;Goals;Grant;Healthcare Systems;High Fat Diet;Homeostasis;Hormone secretion;Human;Immunohistochemistry;in vivo;Individual;inhibitor;innovation;Insulin-Dependent Diabetes Mellitus;Intestines;Knockout Mice;Large Intestine;LGR5 gene;Ligands;Link;Malignant neoplasm of gastrointestinal tract;Measures;Mentored Research Scientist Development Award;Messenger RNA;Metabolic;metabolic phenotype;Methods;Molecular;Molecular Target;mouse Neurog3 protein;Mus;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel therapeutics;Obese Mice;Obesity;Pathogenesis;Pathway interactions;Patients;Persons;Pilot Projects;Population;PPAR delta;Prevalence;progenitor;Reporter;Research;Risk;Role;Signal Transduction;single-cell RNA sequencing;Small Intestines;stem;stem cell homeostasis;stem cell proliferation;stem cells;Stomach;Stress;Supporting Cell;Testing;Tissues;transcription factor;United States;Work

PROJECT_TITLE: Mechanisms of Obesity-related Altered Stomach Plasticity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]