FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE One of the most prevalent problems in children with sickle cell disease are silent cerebral infarcts, small regions of the brain where cells are injured or dead. Silent cerebral infarcts lead to serious problems such as future strokes and learning disabilities, but we do not currently understand why they happen and therefore do not have good ways of preventing them. This proposal will use MRI to measure blood flow throughout the brain in children with sickle cell disease to understand how changes in blood supply may be related to the development of silent cerebral infarcts.

PI_NAMEs: ZVOLANEK, KRISTINA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 4D MRI;Acute;Address;Adult;Anatomy;Area;Arteries;Biological Markers;Blood;Blood flow;Blood Flow Velocity;blood oxygen level dependent;Blood Vessels;Board Certification;Brain;Brain region;Carbon Dioxide;cell injury;Cephalic;cerebral artery;Cerebral hemisphere;cerebral hemodynamics;Cerebral Infarction;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;cerebrovascular reactivity;Child;Childhood;Circle of Willis;Clinical;Clinical Protocols;clinically relevant;cohort;comparison control;cortex mapping;Coupled;Coupling;Data;Development;Distal;Fellowship;Four-dimensional;Functional disorder;Future;Goals;Health;hemodynamics;Heterogeneity;high risk;Imaging Techniques;Impaired cognition;Impairment;improved;individual patient;Infarction;Ischemia;ischemic lesion;Lead;Learning Disabilities;Link;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;MRI Scans;National Research Service Awards;neglect;Nervous System Trauma;Neurologic Deficit;novel;Oxygen;Pathogenesis;Patients;Performance;pre-doctoral;Prevalence;prevent;Prevention;Preventive therapy;Process Assessment;Prospective Studies;Protocols documentation;Recording of previous events;response;Risk;Risk Assessment;Risk Factors;risk stratification;Role;Schools;screening;Screening procedure;Sickle Cell;Sickle Cell Anemia;Source;Spatial Distribution;stressor;Stroke;stroke risk;success;Testing;Tissues;Transcranial Doppler Ultrasonography;Triage;ultrasound;Variant;Vascular blood supply;Vasodilator Agents;Work

PROJECT_TITLE: Probing silent cerebral infarct pathogenesis in sickle cell disease with cerebrovascular MRI


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PI_NAMEs: KRISCHER, JEFFREY P (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: 3-Dimensional;Adherence;Clinical;clinical center;Clinical Research;Committee Members;Communication;Conduct Clinical Trials;Data;Data Collection;Data Coordinating Center;data quality;design;Development;Ensure;follow-up;Funding;Insulin-Dependent Diabetes Mellitus;Laboratories;Manuals;meetings;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;operation;Performance;Prevention;Procedures;protocol development;Publications;Quality Control;Questionnaires;Records;recruit;Reporting;repository;Research;Research Project Grants;research study;response;Safety;Sampling;Site;Standardization;symposium;System;Update

PROJECT_TITLE: Data Coordinating Center for Type 1 Diabetes TrialNet


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: N AR R AT IVE The financial and societal cost of caring for 5.7 million people in the U.S. with Alzheimer disease (AD) is staggering and the suffering to those afflicted by AD and their families is incalculable. We expect that the Framingham Heart Study Brain Aging Program will improve our understanding of the roles of vascular and inflammatory factors in AD, identify new biomarkers for early diagnosis and prediction of disease course, determine circumstances that may lead to disease prevention and suggest potential novel therapeutic targets.

PI_NAMEs: AU, RHODA ;FARRER, LINDSAY A. (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Acceleration;Age;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease risk;Archives;Biological Markers;biomarker identification;Blood Vessels;Boston;Brain;brain health;brain magnetic resonance imaging;care costs;central database;Chronic;Clinical;Cognitive;cognitive change;cohort;Cohort Studies;Communities;comorbidity;Complement;Consensus;Data;data resource;Data Set;data sharing;Dementia;dementia risk;Detection;Diagnosis;digital;Digital biomarker;digital data;Disease;disorder prevention;Early Diagnosis;Exclusion;Family;Financial cost;Framingham Heart Study;Future;Generations;Genes;Genetic;genetic analysis;genetic association;Genetic Predisposition to Disease;genome-wide;Goals;health data;Image;Impaired cognition;improved;Inflammation;Inflammatory;Infrastructure;innovation;late life;Leadership;Life Style;lifestyle data;Link;longitudinal analysis;Magnetic Resonance Imaging;Measures;member;middle age;Monitor;MRI Scans;multi-ethnic;Neuroglia;Neurologic;neuropathology;Neuropsychological Tests;Neuropsychology;new therapeutic target;novel;offspring;organizational structure;Paper;Parents;Participant;Pathogenesis;Pathway interactions;Peripheral;Persons;Phenotype;Pilot Projects;Play;pre-clinical;programs;Proteins;Publishing;Qualifying;Research;Research Personnel;research study;resilience;Resources;response;Risk;Risk Factors;Role;societal costs;Spouses;Structure;Symptoms;targeted treatment;trait;Universities;Writing

PROJECT_TITLE: Precision Monitoring and Assessment in the Framingham Study: Cognitive, MRI, Genetic and Biomarker Precursors of AD & Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: FARRER, LINDSAY A. (contact)

PROJECT_TERMS: Accounting;Address;adjudication;Administrative Personnel;Advisory Committees;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Ancillary Study;Applications Grants;Behavioral;Biological Markers;Boston;Brain imaging;Budgets;Clinic;Clinical;Cognitive;cohort;Collaborations;Communities;Contracts;Data;data access;data resource;Dementia;Diagnosis;effectiveness evaluation;Ensure;Etiology;Faculty;Feedback;Formulation;Fostering;Framingham Heart Study;Funding;Genetic;Goals;Grant;Health;human subject;improved;Infrastructure;innovation;Institution;Interactive Communication;International;Leadership;Magnetic Resonance Imaging;medical schools;meetings;Mission;Monitor;National Heart, Lung, and Blood Institute;National Institute on Aging;Neurologic;neuropathology;Neuropsychological Tests;Neuropsychology;operation;Outcome;Participant;Pathogenesis;payment;Performance;Persons;Pilot Projects;Policies;Postdoctoral Fellow;Process;Productivity;programs;Progress Reports;Public Health;Publications;Reporting;Research;Research Activity;Research Personnel;Research Priority;Research Support;Resources;Schedule;Science;Source;success;symposium;synergism;Thinking;Time;Travel;United States National Institutes of Health;Universities;University adminstration;Wages

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: AU, RHODA  (contact)

PROJECT_TERMS: adjudication;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease risk;Alzheimer’s disease biomarker;Attenuated;Autopsy;Biological Markers;Blood Vessels;Brain;brain magnetic resonance imaging;Cessation of life;Charge;Clinic;Clinical;Clinical assessments;clinical examination;Code;Cognition;Cognitive;Cognitive aging;cognitive change;cohort;Cohort Studies;Collection;Communities;Consensus;Data;data resource;Databases;Dementia;dementia risk;Derivation procedure;Detection;Diagnosis;Diagnostic;diagnostic criteria;Diffusion Magnetic Resonance Imaging;digital;digital measure;Disease Resistance;Enrollment;Evaluation;Framingham Heart Study;Frontotemporal Dementia;Generations;Genetic;Home;Hypothalamic structure;Impaired cognition;interest;Lewy Bodies;Lewy Body Dementia;Life Style;Magnetic Resonance Imaging;Measures;meetings;member;Metabolic;middle age;mild cognitive impairment;Monitor;MRI Scans;multi-ethnic;Neurologist;Neurology;neuropathology;Neuropsychological Tests;Neuropsychology;novel;Nursing Homes;offspring;operation;Parents;Participant;Phenotype;Plasma;Predictive Factor;Prevention strategy;Process;programs;protective factors;Protocols documentation;recruit;repository;Research;research clinical testing;resilience;Resistance;response;Retrieval;Risk Factors;Spouses;Structure;Time;Update;Vascular Dementia;Voice;white matter;Writing

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Regenerative Medicine;Transplantation

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

ORG_STATE: MD

PHR: PROJECT NARRATIVE The continuation of CITR under Emmes’ professional, multi-disciplinary management will ensure collection of high quality data on allogeneic and autologous islet transplantation/beta cell replacement therapies, pancreatectomy-alone, and additional clinical treatment advances. Emmes works to assess health outcomes, which leads to high-impact manuscripts, addressing existing gaps of knowledge in the field for persons with type 1 diabetes and glycemic lability.

PI_NAMEs: PAYNE, ELIZABETH HOLLY (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Allogenic;Autologous;beta cell replacement;Biometry;Case Report Form;Cell Physiology;cell replacement therapy;Clinical;Clinical Treatment;Collaborations;Collection;Communication;Communities;Complex;Data;Data Collection;data exchange;data registry;Data Reporting;Development;Diabetes Mellitus;Ensure;experience;flexibility;follow-up;Funding;Goals;Health;health assessment;Human;Hypoglycemia;Insulin-Dependent Diabetes Mellitus;International;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Journals;Knowledge;Lead;Leadership;Manuscripts;meetings;Methods;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Outcome;Pancreatectomy;Peer Review;Persons;Positioning Attribute;posters;programs;Publications;quality assurance;Refractory;Registries;Research Personnel;Resolution;response;Running;Safety;Secure;Security;Site;Source;Statistical Data Interpretation;success;Therapeutic;transplant registry;Transplantation;U-Series Cooperative Agreements;Validation;Work

PROJECT_TITLE: Continuation of The Collaborative Islet Transplantation Registry (CITR)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: MASSARO, JOSEPH MICHAEL (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Alzheimer's Disease;Alzheimer's disease risk;Back;Biological Markers;Biotechnology;Brain;brain magnetic resonance imaging;Cardiovascular Diseases;Characteristics;Clinical;Clinical Data;Cognition;Cognitive;cognitive change;cohort;Collection;Communities;comorbidity;Complex;Computers;Contracts;Data;Data Analyses;Data Collection;data curation;data exchange;data format;data management;data repository;Data Set;data sharing;database of Genotypes and Phenotypes;Databases;Dementia;Deposition;design;Development;Diagnosis;Disease;epidemiology study;Framingham Heart Study;Funding;Future;Generations;Genetic;Grant;Health;Impaired cognition;late life;life span;Life Style;Link;Magnetic Resonance Imaging;mental state;Methods;mild cognitive impairment;Monitor;MRI Scans;multi-ethnic;multiple datasets;National Heart, Lung, and Blood Institute;National Institute on Aging;neuroimaging;neuropathology;Neuropsychological Tests;Neuropsychology;offspring;operation;Participant;phenotypic data;Plasma;pre-clinical;programs;Protocols documentation;Quality Control;Recommendation;recruit;Reporting;Research;Research Design;Research Personnel;resilience;Risk;screening;Secure;Serum;Social Network;sociodemographics;Source;Spouses;Statistical Data Interpretation;Stroke;Structure;Time;Update

PROJECT_TITLE: Data Core


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CAMBRIDGE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Narrative In this project at MIT, we will complete and demonstrate a benchtop cryogen-free 23.5-T/25-mm high-temperature superconducting magnet for 1-GHz microcoil NMR spectroscopy that will provide an affordable, small-footprint ultra-high-field solution to the entire NMR community. The innovative design included in this magnet will pave the way to the next generation—a compact, helium-free, and cost-effective—high-resolution ≥1-GHz NMR spectroscopy, thereby enabling high-impact application of superconductivity to the forefront of biomedical sciences.

PI_NAMEs: PARK, DONGKEUN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Adopted;Age;Charge;Communities;Copper;cost;cost effective;cryogenics;design;Development;Diameter;Exploratory/Developmental Grant;Frequencies;Funding;Future;Helium;High temperature of physical object;innovation;Iron;Lead;Length;Liquid substance;manufacturing process;Mechanics;Methods;next generation;NMR Spectroscopy;Nuclear Magnetic Resonance;operation;programs;protein complex;prototype;Radial;Research;Research Project Grants;Resolution;Resources;Science;screening;Site;Source;Specific qualifier value;Stress;structural biology;superconductivity;System;Techniques;Technology;Temperature;Thinness;tool;Work

PROJECT_TITLE: A Benchtop Cryogen-Free 23.5-T/25-mm-RT-Bore Magnet for 1-GHz microcoil NMR Spectroscopy

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


PI_NAMEs: MCKEE, ANN C. (contact)

PROJECT_TERMS: aging brain;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;Ancillary Study;Argyrophilic Grain Disease;Attenuated;Autopsy;Behavioral;Biochemical;Biological Assay;Biological Markers;Biological Sciences;Boston;Brain;brain tissue;Cell Count;cerebrovascular pathology;Cessation of life;Clinical;clinical diagnosis;Cognitive;cohort;Collection;Communication;Communities;Consensus;cytokine;Data;demented;Dementia;density;Development;Diagnosis;Diagnostic;diagnostic criteria;digital;Digital Libraries;digital technology;Disease;Elderly;Enrollment;Epitopes;Evaluation;Family member;Framingham Heart Study;Funding;Future;Genetic;Gliosis;Heterogeneity;hippocampal sclerosis;Image Analysis;Immunohistochemistry;impression;Lewy Bodies;Magnetic Resonance Imaging;Measurement;Measures;meetings;Methods;mild cognitive impairment;Monitor;Myelin;neuroinflammation;neuropathology;new technology;novel;operation;Outcome;Participant;Pathologic;Pathology;Pattern;Phenotype;Prevalence;Probability;programs;Proteins;Protocols documentation;Qualitative Methods;Recording of previous events;Research Personnel;Slide;Specific qualifier value;Stains;Systems Analysis;tau Proteins;Time;Tissues;Translations;Universities;Vascular Diseases

PROJECT_TITLE: Neuropath Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Fatigue Syndrome (ME/CFS);Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Narrative A subset of individuals with SARS-COVID-2 infection suffer from long term consequences (Long COVID). The core symptoms are remarkably similar to chronic fatigue syndrome (CFS) including debilitating fatigue and dysautonomia. The disease onset shows remarkable interindividual variation and can be triggered by mild disease. This grant contributes to our understanding of the underlying and possibly shared genetic risk factors behind Long COVID and CFS and the impact from infectious triggers on disease risk. The findings will elucidate genetic risk factors and enable the development of prevention strategies for CFS and Long COVID.

PI_NAMEs: SAXENA, RICHA  (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: 2019-nCoV;Affect;Autoimmune;Autoimmunity;biobank;Biological;Cells;Chronic Fatigue Syndrome;cohort;comorbidity;COVID-19;COVID-19 impact;COVID-19 pandemic;Data;Development;Diagnosis;disability;Disease;disease diagnosis;Disease Pathway;disorder risk;Dysautonomias;Environment;Environmental Risk Factor;Etiology;Fatigue;flu;Future;General Population;Genetic;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;Goals;Grant;Headache;Health;Heart Rate;Heritability;HLA Antigens;Hypersensitivity;Immune;Immune response;Immune System Diseases;Individual;individual response;Infection;Infection prevention;Inflammation;insight;inter-individual variation;Life;Long COVID;Lung;Mendelian randomization;Meta-Analysis;Molecular Mimicry;Onset of illness;pathogen;Population;Prevalence;Prevention strategy;Public Health;Recovery;Refractory;Relapse;Research;respiratory;response;Risk;Risk Factors;risk variant;SARS-CoV-2 infection;severe COVID-19;Shapes;Siblings;symptomatology;Symptoms;System;Testing;Time;Tissues;trait;Twin Multiple Birth;Variant;Viral;Work;working group

PROJECT_TITLE: Long COVID as a putative subtype of chronic fatigue syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CFS-N(80)S]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's Disease Pathway;Alzheimer's disease risk;Amyloid beta-Protein;Biological Markers;Blood Glucose;Blood Pressure;Blood Vessels;Body mass index;Brain;brain magnetic resonance imaging;cardiovascular risk factor;Chronic;cigarette smoking;Clinical;Cognition;Cognitive;cognitive ability;Cognitive aging;cohort;Communities;comorbidity;Data;Data Set;Databases;Dementia;Diagnosis;digital;Disease;disease prognosis;Early Diagnosis;Education;effective therapy;endophenotype;Environment;Framingham Heart Study;Future;Genes;Genetic;genome wide association study;Genomics;Genotype;Goals;Health;high risk;high risk population;IL6 gene;Impaired cognition;in vivo;indexing;Individual;Inflammation;Inflammatory;inflammatory marker;insight;Investigation;late life;Life Style;Link;Lipids;Magnetic Resonance Imaging;Measures;Mendelian randomization;Metabolic;methylome;middle age;model building;Modeling;Monitor;MRI Scans;Nerve Degeneration;neuropathology;Neuropsychology;novel;Onset of illness;Outcome;Participant;Pathology;personalized medicine;Phenotype;Physiological;Plasma;pleiotropism;predictive modeling;Prevention;Process;prospective;resilience;Resistance;Resources;response;Risk;Risk Factors;secondary analysis;sex;statistics;Structure;Symptoms;tau Proteins;Testing;Time;TNF gene;trait;transcriptome;Variant;vascular risk factor;whole genome

PROJECT_TITLE: Genomic, physiological, and environmental predictors of AD risk, resilience and resistance


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: COVID-19 pandemic highlights the impact of emerging infectious diseases and the global socioeconomic impact. Alphairuses such as the chikungunya virus (CHIKV) has re-emerged along with many arthropod-borne viruses (arboviruses), which continue to pose a significant threat to global human health especially with recent vector expansion into non-endemic regions with no approved therapeutics. Our work will define and develop lead host directed therapeutics to address this gap through virology and medicinal chemistry efforts.

PI_NAMEs: AMARASINGHE, GAYA K. (contact);BLAGG, BRIAN S J

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Address;Aedes;Alpha Virus;analog;Arboviruses;arthropod-borne;Binding;chikungunya infection;Chikungunya virus;Classification;Clinical;Combined Modality Therapy;Comparative Study;COVID-19 pandemic;Culicidae;Data;Development;Disease;Dose;economic impact;efficacious treatment;Emerging Communicable Diseases;Endoplasmic Reticulum;Exhibits;Family;Fever;Frequencies;Genes;Genotype;Geographic Locations;Geography;Health;Heat-Shock Proteins 90;HSP 90 inhibition;Human;In Vitro;in vivo;indexing;inhibitor;innovation;insight;Knowledge;Lead;lead optimization;Link;Mayaro virus;Metabolism;Mitochondria;Molecular Chaperones;Mus;Nonstructural Protein;novel;novel therapeutics;O'nyong-nyong virus;paralogous gene;Pharmaceutical Chemistry;pharmacologic;Phase;Positioning Attribute;Posture;Predisposition;Property;prophylactic;Proteins;Proteomics;Recording of previous events;response;Role;Ross river virus;scaffold;Semliki forest virus;Serum;small molecule;socioeconomics;Solubility;Structure-Activity Relationship;Testing;Therapeutic;Togaviridae;Toxic effect;transmission process;Universities;vector;Venezuelan Equine Encephalitis Virus;Viral;Viral Load result;Viral Physiology;Viremia;Virion;virology;Virus;Virus Diseases;Washington;Work

PROJECT_TITLE: HSP90 paralog selective small molecules as anti-old-world alpha-viral therapeutic leads.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Genetic Testing;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

PI_NAMEs: QIU, WEI QIAO WENDY (contact)

PROJECT_TERMS: Acceleration;Affect;Age;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease test;Alzheimer’s disease biomarker;Autopsy;biobank;Biological Markers;biomarker signature;Blood;Brain;brain magnetic resonance imaging;brain morphology;Brain Pathology;brain tissue;brain volume;C-reactive protein;Chronic;Cognition;Cognitive;cognitive function;cohort;Cohort Studies;Data;Data Set;Dementia;disease prognosis;disorder risk;DNA Methylation;Early Onset Alzheimer Disease;Encephalitis;Framingham Heart Study;Genes;Genetic;Genetic Diseases;Genetic Polymorphism;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;genome-wide analysis;Genotype;Hippocampus;human old age (65+);Hypothalamic structure;Immunologic Markers;Impaired cognition;Incidence;Inflammation;Inflammatory;inflammatory marker;insight;Investigation;Koreans;Late Onset Alzheimer Disease;lipidomics;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Memory;Mendelian randomization;metabolomics;Microglia;mild cognitive impairment;Molecular Profiling;Monitor;neuroimaging;neuropathology;Participant;Pathogenesis;Pathology;Pathway interactions;Peripheral;personalized approach;personalized medicine;Persons;polygenic risk score;prevent;Prevention;Process;prospective;Proteomics;Reaction;Research;research clinical testing;Risk;Risk Reduction;risk variant;Role;Senile Plaques;Structure;Subgroup;System;Tauopathies;Temporal Lobe;Testing;trait;transcriptome sequencing;transcriptomics;Translating;Universities;Variant;Washington

PROJECT_TITLE: Characterizing the interaction of genetic vulnerabilities and chronic peripheral inflammation for AD risk


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: STEIN, THOR  (contact)

PROJECT_TERMS: Acceleration;age related;Aging;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease related dementia;Apolipoprotein E;Arterioloscleroses;Astrocytes;Astrocytosis;Attenuated;Autopsy;Biological Markers;Blood;Blood Glucose;Blood Pressure;Body mass index;Brain;brain control;Brain imaging;Brain region;brain tissue;Cerebral Amyloid Angiopathy;Cerebrovascular Disorders;cigarette smoking;Classical Complement Pathway;Clinical;Cognitive;cognitive function;cognitive testing;cohort;Cohort Studies;Collaborations;Communities;Complement;Complement 1q;Complement 4b;Complement component C4a;complement pathway;cytokine;Data;Development;differential expression;Elderly;Framingham Heart Study;frontal lobe;Functional disorder;Gene Expression;Genes;Genetic;Genetic Screening;genetic testing;Genetic Transcription;genetic variant;Genotype;Gliosis;imaging biomarker;Impaired cognition;Inflammatory;insight;Light;Lipids;Magnetic Resonance Imaging;Measures;Monitor;Neurobehavioral Manifestations;neuroinflammation;neuropathology;Neuropsychology;new therapeutic target;novel;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;Phenotype;Population Study;Protein Isoforms;Proteins;Research Project Grants;Resources;Risk;RNA Sequence Analysis;Role;Sampling;Schizophrenia;Single Nucleotide Polymorphism;Subgroup;Symptoms;Synapses;tau Proteins;tau-1;Techniques;Transcript;transcriptome;transcriptome sequencing;Variant;vascular risk factor

PROJECT_TITLE: Role of classical complement pathway underling glial phenotypes and multiple pathologies in Alzheimer's disease and cerebrovascular disease


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Immunotherapy;Kidney Disease;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: PITTSBURGH

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: NARRATIVE This project will investigate the ability of vascular normalizing therapies to condition the tumor microenvironment in a manner that is conducive for the development of specialized tertiary lymphoid structures that foster tumor- infiltrating T cell fitness and local diversification in the protective anti-tumor T cell repertoire. Furthermore, based on remarkable gender/sexual dimorphism observed in this operational paradigm, we will investigate the capacity of androgen synthesis inhibitors and androgen receptor antagonists to improve co-therapy outcomes to define novel combination immunotherapies for future translation into the clinic for the more effective treatment of female and male patients with renal cell carcinoma (RCC).

PI_NAMEs: MARANCHIE, JODI KATHLEEN;STORKUS, WALTER J. (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Abbreviations;Androgen Receptor;Androgens;Angiogenesis Inhibitors;Animal Model;antagonist;Antigen Targeting;Antigens;Apoptosis;Attention;Autologous;Autologous Dendritic Cells;Biological Assay;biosignature;Blood;Blood flow;Blood Vessels;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Classification;Clear cell renal cell carcinoma;Clinic;Clinical;Clinical Trials;Combination immunotherapy;Cross-Priming;cytokine;Dendritic Cells;design;Development;Diagnosis;dimorphism;Disease Progression;Dose;effective therapy;enzyme linked immunospot assay;Epitopes;Excision;exhaust;Exhibits;Female;fitness;Fostering;Future;Gender;Gender Issues;Generations;Genetic Transcription;Gonadal Steroid Hormones;HLA-A2 Antigen;Human;Hypoxia;Immune;immune cell infiltrate;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;immunogenic;immunogenic cell death;immunogenicity;Immunologics;Immunotherapy;improved;In Situ;in vivo;Inbred BALB C Mice;Incidence;Infiltration;Inflammation;Inflammatory;inhibitor;Intercellular Fluid;Interferon Type II;Interleukin-2;Interruption;Intervention;Lymphocyte;Lymphoid;lymphoid organ;Maintenance;male;Male Castration;Malignant Neoplasms;Mediating;Melanoma patient;Mus;necrotic tissue;Neoplasms in Vascular Tissue;novel;Operative Surgical Procedures;Oral;patient response;Patients;Peptide Vaccines;Peptides;Perfusion;Pericytes;Phase;Phase II Clinical Trials;Phenotype;pressure;Prognosis;prognostic indicator;receptor;Receptor Signaling;recruit;Renal Cell Carcinoma;Resistance;response;Role;sexual dimorphism;Site;Sterility;Structure;synergism;Systems Biology;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T cell therapy;T-Lymphocyte;tertiary lymphoid organ;Testing;Therapeutic;Therapeutic Intervention;therapy outcome;Translations;Treatment Efficacy;treatment response;tumor;Tumor Expansion;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue;Vaccination;Vaccine Antigen;vaccine efficacy;vaccine immunotherapy;Vaccines;Vascular Endothelial Cell;women's treatment

PROJECT_TITLE: Vaccine Targeting of RCC Blood Vessels to Promote TME Normalization and Enhance TIL Recruitment

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Mitotic spindle orientation plays essential roles in the development of the epidermis and in suppressing tissue overgrowth in response to oncogenic mutations. This work will examine the mechanisms regulating spindle orientation and how they affect epidermal architecture and function.

PI_NAMEs: LECHLER, TERRY H (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: adaptive immune response;Adult;Affect;Anus;Architecture;Buffers;cardiogenesis;Cell division;Cell Fate Control;Cells;Collaborations;Data;Defect;Development;Embryo;Epidermis;Exhibits;Funding;Generations;Genitalia;Goals;Growth;Hair;Hair follicle structure;Head and Neck Squamous Cell Carcinoma;Homeostasis;Human Papillomavirus;In Vitro;insight;keratinocyte;Kinesin;Malignant Neoplasms;Microtubules;Mitotic spindle;Molecular;Morphogenesis;mouse model;Mus;Mutant Strains Mice;Mutation;neurodevelopment;Normal tissue morphology;novel;Oncogenes;Oncogenic;Papillomavirus Transforming Protein E6;Pathogenicity;Physiology;Play;polypeptide;Positioning Attribute;progenitor;Proteins;response;Role;Skin;skin organogenesis;Stratification;three dimensional structure;Time;Tissues;tool;tumor;tumor growth;Viral;Virus;Work

PROJECT_TITLE: Spindle Orientation in Skin Development and Homeostasis

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE This proposal will identify an elusive metabolic process centrally governing the immunosuppressive function and expansion of myeloid cells in tumors, which could significantly increase the efficacy of promising approaches for cancer immunotherapy. Specifically, information gathered from this effort is expected to: 1) provide insights into the metabolic signals underlying mitochondrial adaptation and immunoregulatory polarization of myeloid cells in tumors; 2) set the foundation for the development of novel systems to functionally reprogram myelopoiesis in cancer; and 3) boost the effectiveness of immunotherapy by transforming “cold” tumors into “hot” malignancies highly infiltrated by reactive T cells and reprogrammed myeloid cells that sustain anti-tumor activities.

PI_NAMEs: RODRIGUEZ, PAULO CESAR (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: Ablation;anti-cancer;arm;Beds;biological adaptation to stress;cancer cell;cancer immunotherapy;Cancer Patient;carcinogenesis;Cell Physiology;Cells;Chronic;Clinical;cytotoxic;Dendritic Cells;Development;effective therapy;Effectiveness;effector T cell;Emergency Situation;Endoplasmic Reticulum;endoplasmic reticulum stress;Exposure to;Foundations;Genetic;Goals;Homeostasis;Hypoxia;immune cell infiltrate;Immune Evasion;Immunity;immunoregulation;Immunosuppression;Immunotherapy;Impairment;Individual;Infiltration;Inflammatory;information gathering;inhibitor;insight;Link;Malignant Neoplasms;Manuscripts;Metabolic;Metabolism;Mitochondria;Mus;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Nitrogen;novel;nutrient deprivation;OmpR protein;Oxygen;Pathologic;Pathway interactions;Process;Program Sustainability;programs;protein folding;Proteins;Research;response;Role;Signal Transduction;Stress;Stress Response Signaling;System;T cell response;T-Lymphocyte;Therapeutic;therapeutic target;Time;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: Mitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: This project studies how cells that die, in particular those neurons dying of necrosis after injury, are recognized by engulfing cells, an event that leads to the internalization and digestion of these dying neurons. During stroke, cancer, and other traumatic situations, many cells undergo necrosis and apoptosis after injury; the swift removal of these cells prevents tissue injury, inflammatory responses, and auto-immune responses, clears the wounded area, and promotes tissue repair. Understanding the mechanisms controlling the recognition of necrotic neurons will have important therapeutic implications in fighting chronic inflammatory and auto-immune diseases, and in treating neurodegenerative diseases and stroke.

PI_NAMEs: ZHOU, ZHENG  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: age related deterioration;Alleles;Alzheimer's Disease;Animals;Apoptosis;Apoptotic;ATP-Binding Cassette Transporters;Autoimmune Diseases;Autoimmune Responses;Axon;axon injury;Biochemical;Caenorhabditis elegans;Cell Death;Cell Death Process;Cell membrane;Cell Separation;cell suicide;Cells;chronic inflammatory disease;Cytoplasm;Development;Digestion;Disease;dominant genetic mutation;Eating;Endoplasmic Reticulum;Endosomes;epithelial Na+ channel;Event;Evolution;Excision;Family;fighting;Gene Mutation;gene product;Genes;genetic analysis;Genetic Epistasis;Genetic Screening;Goals;Health;Homeostasis;Homologous Gene;Human;in vitro Assay;Induced Mutation;Inflammatory Response;Injury;Ion Channel Protein;Learning;Life;Malignant Neoplasms;Mediating;member;Microglia;model organism;Molecular;Morphology;mutant;Natural regeneration;Necrosis;Necrosis Induction;Nematoda;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;novel;Outcome;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Phosphatidylserines;phospholipid scramblase;Phospholipids;Physiological;Prealbumin;prevent;Process;Protein Family;Proteins;receptor;Recovery;Recycling;repaired;response;Role;Side;Signal Transduction;Stress;Stroke;stroke recovery;Surface;Synapses;tat Protein;Testing;Therapeutic;tissue injury;tissue repair;Touch sensation;Translating;Wounded area

PROJECT_TITLE: How are necrotic neurons recognized by their phagocytes

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_DEPT: SURGERY

PHR: Porcine islet xenotransplantation is a promising treatment for type 1 diabetes (T1DM), provided that an appropriate genetically-modified donor pig can be identified, and a clinically available and tolerable immunosuppressive regimen can be developed to ensure successful engraftment and rejection-free survival of the transplanted islets. The overall goal of the proposed studies therefore is to use our established preclinical model of islet xenotransplantation to study strategies of porcine islet modifications and recipient immunomodulation that will promote porcine islet engraftment and survival. We hope to advance porcine islet xenotransplantation for T1DM from preclinical studies to clinical reality.

PI_NAMEs: KIRK, ALLAN D. (contact);LUO, XUNRONG

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Affect;allograft rejection;allotransplant;Animal Experimentation;Animals;Antigen-Presenting Cells;Antithymoglobulin;Apoptosis;Apoptosis Inhibitor;Apoptotic;B-Lymphocytes;base;Beta Cell;beta cell replacement;CD28 gene;CD46 Antigen;Cell Adhesion Molecules;Cell Physiology;cell replacement therapy;Cell Survival;Cell Therapy;Cells;Characteristics;Clinical;clinical application;Clinical Trials;Combined Modality Therapy;comorbidity;CRISPR/Cas technology;Data;Development;diabetic;effective therapy;Engraftment;Ensure;experience;Exposure to;Family suidae;Funding;Galactosyltransferases;Gene Modified;Genes;Genetic;Goals;Graft Rejection;Health Care Costs;Human;humanized mouse;Immune;immunogenicity;immunoregulation;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;In Vitro;in vivo;Individual;Industry Collaboration;Infusion procedures;inhibitor;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intuition;Investments;islet;Islet Cell;islet xenograft;Islets of Langerhans Transplantation;Knock-out;Lentivirus Vector;Ligands;Link;Macaca mulatta;Mediating;Medical;Methods;Modeling;Modification;Morbidity - disease rate;mouse model;Mus;Neonatal;nonhuman primate;novel;novel strategies;novel therapeutics;Organ Donor;Oryctolagus cuniculus;Outcome;overexpression;Pancreas;Pancreas Transplantation;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;porcine model;pre-clinical;Pre-Clinical Model;preclinical study;prevent;Primates;Productivity;Protocols documentation;receptor;Regimen;resilience;Role;Sirolimus;Source;Splenocyte;success;synergism;T-Lymphocyte;Tacrolimus;targeted treatment;Testing;Therapeutic;TNFRSF5 gene;TNFSF5 gene;transgene expression;Transgenes;Transgenic Organisms;Translating;Translations;transplant model;Transplantation;United States;Work;Xenograft procedure

PROJECT_TITLE: Neonatal porcine islet xenografts for the treatment of type 1 diabetes


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Back Pain;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Pain Research

ORG_CITY: ROCHESTER

ORG_NAME: ROCHESTER INSTITUTE OF TECHNOLOGY

ORG_STATE: NY

PHR: NARRATIVE Stiffening and disorganization of the extracellular matrix (ECM) can serve as important cellular cues that can promote degenerative processes. The proposed study will determine the relevance of substrate stiffness and topography on the activation of the mechanoreceptor TRPV4 in annulus fibrosus cells and will elucidate whether TRPV4 regulates ECM synthesis/remodeling. Investigating cell-substrate interactions in the annulus fibrosus is of high significance as it will help to properly understand mechanotransduction processes underlying spinal health and disease (e.g. intervertebral disc herniation) and advance tissue engineering approaches.

PI_NAMEs: WUERTZ-KOZAK, KARIN  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Affect;Aging;Agonist;Apoptosis;Architecture;Area;Atomic Force Microscopy;Cattle;cell behavior;Cell Physiology;cell type;Cells;Collagen;Communities;cost;Cues;culture plates;Data;design;Detection;Development;disability;Disease;Disease Progression;Economic Burden;Enzyme-Linked Immunosorbent Assay;Enzymes;Extracellular Matrix;Failure;Feedback;Fibroblasts;Focal Adhesions;Genes;Goals;Government;Health;in silico;Individual;innovation;interest;Intervertebral disc structure;Ion Channel;Knowledge;Low Back Pain;Measures;mechanical load;mechanical properties;mechanical signal;Mechanical Stimulation;Mechanics;Mechanoreceptors;mechanotransduction;Microfilaments;multi-scale modeling;new therapeutic target;Pain management;Pathway interactions;Periodicity;pharmacologic;Play;Polarization Microscopy;polydimethylsiloxane;Prevalence;Process;Proteins;regenerative approach;release of sequestered calcium ion into cytoplasm;Research;response;Role;Slipped Disk;Spinal;Stretching;Structure;Substrate Interaction;Tissue Engineering;Tissues;tool;transcriptome sequencing;TRP channel;Western Blotting;Work

PROJECT_TITLE: Substrate Stiffness, Topography, and TRPV4 in AF Mechanotransduction


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative  Hematopoietic Stem cells (HSCs) must balance self-renewal and differentiation to give rise to all the mature hematopoietic cells and sustain the longevity of the organism. This proposal will ascribe an etiology to the heterogeneity within in the stem cell compartment by attributing differences in stem cell behavior to the actions of a dose-dependent, homeodomain-containing transcription factor, CUX1. An understanding of the molecular cause and cellular consequences of HSC heterogeneity could provide methods to modulate stem cell behavior to treat hematopoietic disease.

PI_NAMEs: MARTINEZ, TANNER CLARK (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Address;Binding;Bioinformatics;Biological;Biology;Blood Platelets;Body System;C-terminal;Catastrophic Illness;Cations;cell behavior;Cell Compartmentation;Cell Cycle;Cell Line;Cell surface;Cells;Childhood;Chromatin;Chromatin Remodeling Factor;Chromosomes;Clinical;Communication;Cues;Cytoplasm;Data;Deposition;Development;Developmental Biology;Diagnosis;Disease;dosage;Dose;Dysplasia;Enhancers;epigenomics;Equilibrium;Erythropoiesis;Etiology;Exhibits;extracellular;Fluorescence;Gene Expression;gene repression;Generations;Genes;Genetic Transcription;Genomics;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;Heterogeneity;high risk;homeodomain;Homologous Gene;Human;Immunophenotyping;improved outcome;insight;K562 Cells;knock-down;knowledgebase;Link;Longevity;Lymphoid;Lymphopoiesis;Maps;Mentors;Methods;Modeling;Molecular;molecular scale;mouse model;Multipotent Stem Cells;Mus;Mutation;Myelogenous;Myelopoiesis;Myeloproliferative disease;novel therapeutics;Organism;Outcome;Patients;Performance;Phenotype;Physicians;Play;Population;Property;prospective;Proteins;Recording of previous events;recruit;Recurrence;Regulation;Reporter;Reporting;Reproducibility;Role;Scientist;self-renewal;skills;Sorting;stem cell biology;stem cells;System;Tissues;Training;transcription factor;transcriptome;Transplantation;Tumor Suppressor Proteins;Undifferentiated;Variant

PROJECT_TITLE: Establishing CUX1 as a determinant of Hematopoietic Stem cell heterogeneity


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Pediatric;Rheumatoid Arthritis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE  Juvenile idiopathic arthritis (JIA) is an immune-mediated chronic disease in which T cells produce high levels of inflammatory cytokines. This study aims to understand how rare genetic variants and abnormal signaling pathways cause JIA T cells to make high amounts of the inflammatory cytokines, interleukin 17 and interferon gamma. These discoveries will identify how inflammatory cells and cytokines develop in JIA with the goal of generating novel therapeutic targets and improving diagnostic and therapeutic decisions.

PI_NAMEs: PATRICK, ANNA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: autoimmune arthritis;Autoimmune Diseases;Automobile Driving;Award;Basic Science;Biological Factors;career;career development;Cell Culture Techniques;Cells;Cellular biology;Child;Childhood;Chronic;Chronic Childhood Arthritis;Chronic Disease;Code;cytokine;Cytokine Signaling;Cytometry;Data;Development;Development Plans;Diagnostic;Differentiated Gene;DNA Binding;DNA Sequence Alteration;Drug Targeting;enhancing factor;Environment;Exhibits;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic;genetic risk factor;genetic variant;genome analysis;genome sequencing;genome wide association study;Goals;Human;IL17 gene;Immune;Immunologic Techniques;Immunologist;Immunology;improved;Inflammatory;insight;Institution;Interferon Type II;Interleukin-1;Interleukin-12;joint inflammation;knock-down;Knowledge;loss of function;loss of function mutation;Mediating;Mentors;Modeling;Molecular;Molecular Abnormality;Molecular Biology;Mutation;new therapeutic target;next generation sequencing;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Phenotype;Physicians;Principal Investigator;Process;Production;Program Development;programs;Proteins;Publications;Research;research and development;Research Personnel;Resource Sharing;Resources;Rheumatism;rheumatologist;Role;Scientist;Signal Pathway;Single Nucleotide Polymorphism;skill acquisition;Source;STAT1 gene;STAT3 gene;STAT4 gene;T-Lymphocyte;Techniques;Testing;Th1 Cells;Therapeutic;Training;transcription factor;translational study;Variant

PROJECT_TITLE: Mechanisms of T Cell IFNy and IL-17 Production in Juvenile Idiopathic Arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: ATLANTA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE: This project will result in the development of cluster/cloud scale HistoTools to enable curation of large-scale digital slide data lakes via (a) timely identification of poor-quality slides and slide regions, (b) quantitative metrics driving optimized cohort selection for compensation of batch effects, and (c) generation of highly precise and relevant object annotations and labels. The employment of HistoTools will facilitate (a) the creation of companion diagnostic assays in the cancer, kidney disease, and heart rejection space via curation and release of over 14k WSI, and (b) external collaborators validating the tools on 100k WSI, thus helping drive global onsite curation of well-curated data lakes.

PI_NAMEs: JANOWCZYK, ANDREW ROBERT (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Active Learning;Address;Adoption;Affect;allograft rejection;Antarctica;Automobile Driving;Big Data;Biological;Biopsy;Breast;Cardiac;Categories;Cell Nucleus;cell type;Cells;Characteristics;Clinical;clinical practice;cluster computing;cohort;Communities;companion diagnostics;Compensation;Computer Assisted;computer monitor;cost;Data;data curation;data lake;Data Set;design;Development;Diagnosis;diagnostic assay;digital;digital pathology;Disease;Employment;Ensure;European Union;experience;FDA approved;Feedback;Friends;Generations;Genes;Glass;Head and neck structure;Heart;heart allograft;Histologic;Histological Labelings;Histopathology;Human;Image;improved;Infrastructure;innovation;interest;Kidney;Kidney Diseases;Label;Letters;Lung;Lymphocyte;Lymphocytic Infiltrate;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Morphologic artifacts;Morphology;Neck Cancer;novel;Oncology;Ontology;open source;Organ;organ transplant rejection;Pathologist;pathology imaging;Pathway interactions;patient response;Pattern;Performance;precision medicine;predictive test;Privatization;Process;Prognosis;prognostic;prototype;Quality Control;quantitative imaging;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Resources;Site;Slide;Stains;Testing;Texture;The Cancer Genome Atlas;The Cancer Imaging Archive;Tissues;tool;tool development;treatment response;usability;Validation;web site;whole slide imaging;Work

PROJECT_TITLE: Histotools: scaling digital pathology curation tools for quality control, annotation, labeling, and dataset identification


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Precision Medicine;Sleep Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because OSA is a major health concern that is inadequately treated with existing therapies. The NHLBI 2011 Sleep Disorders Research Plan states that “studies are needed to identify clinically meaningful subtypes [of OSA], and algorithms informing the selection of optimal therapeutic strategies.” The proposed research directly addresses this important component of the NIH's mis- sion.

PI_NAMEs: WELLMAN, DAVID ANDREW (contact)

PROGRAM_OFFICER_NAME: BROWN, MARISHKA

PROJECT_TERMS: Acetazolamide;Address;Algorithms;alternative treatment;Anterior;Apnea;Arousal;atomoxetine;Clinical;Combined Modality Therapy;common treatment;Compensation;Continuous Positive Airway Pressure;Data;Development;Devices;Disease;Drug Targeting;effective therapy;Effectiveness;Electric Stimulation;Epiglottis structure;Failure;follow-up;Goals;Grant;Health;hyoepiglottic ligament;Hypoglossal nerve structure;improved;Individual;Lateral;Left;Logistic Regressions;Mandibular Advancement;Measurement;Measures;Methods;Mission;Movement;National Heart, Lung, and Blood Institute;novel;Obstruction;Obstructive Sleep Apnea;Outcome;outcome prediction;oxybutynin;Palate;Patient Selection;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Pharyngeal structure;pharynx muscle;Physiological;Physiology;pilot test;predicting response;Predisposition;prevent;Public Health;Research;Residual state;respiratory;response;Severities;Signal Transduction;Site;Sleep;Sleep Disorders;success;System;Techniques;Testing;Therapeutic;Tongue;trait;Trazodone;treatment choice;treatment response;treatment strategy;United States National Institutes of Health;Work

PROJECT_TITLE: Predicting response to non-PAP therapies in OSA using PSG-derived endotypes

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Rare Diseases;Substance Misuse;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative From 2005-2014, the rate of alcohol binging among the elderly rose 20% overall and by 50% in women only, and Alcohol use disorder (AUD) in mid-life is shown to be a significant, independent predictor of late-life dementia, particularly vascular cognitive impairment and dementia (VCID) including the Cerebral Amyloid Angiography (CAA) subtype. CAA VCID is accompanied by disruptions in the toxin-clearing flow of fluid in the brain, and there is reason to believe that alcohol abuse can compromise the fluid flow through the brain and worsen the CAA and dementia, particularly later in life. Therefore our goal is to learn how and why (i.e., biochemical regulators) the fluid flow is disrupted and if it can be improved as a potential way to help people with VCID, especially those who engage in risky levels of drinking.

PI_NAMEs: BENVENISTE, HELENE D;MASON, GRAEME F. (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Acceleration;Affect;Alcohol abuse;alcohol effect;alcohol use disorder;Alcoholic beverage heavy drinker;Alcohols;Amyloid;Amyloid beta-Protein;Angiography;Angiotensins;arterial spin labeling;ATP phosphohydrolase;Biochemical;Biochemical Pathway;Biophysics;blood perfusion;Brain;brain tissue;burden of illness;Calcium Signaling;carbonate dehydratase;Central Nervous System;Cerebral Amyloid Angiopathy;Cerebral Ventricles;Cerebrovascular system;Cerebrum;Cessation of life;Chronic;Cognition;Consumption;contrast enhanced;Dementia;Deposition;design;Development;Drainage procedure;drinking;Elderly;Ethanol;experimental study;Fluid Balance;fluid flow;glymphatic function;glymphatic system;Goals;Harvest;Human;Image;Impaired cognition;improved;Inflammation;Inflammatory;Ion Transport;Knowledge;late life;Lateral;Learning;Life;Liquid substance;Literature;Lymph;Lymphatic;lymphatic circulation;lymphatic drainage;lymphatic dysfunction;Lymphatic System;Magnetic Resonance Imaging;Maps;Measures;Mediator;Meningeal lymphatic system;Meninges;Methods;middle age;Modeling;Molecular;morphometry;Nerve Degeneration;Neuroglia;Neuroimmune;Neurons;neurotoxicity;normal aging;novel;Output;Pathology;Pathway interactions;Pattern;Peptides;Perfusion;Persons;prevent;Process;protein function;Proteins;Proteomics;Protons;Rattus;Regulation;Relapse;Renin;Sampling;Series;Signal Transduction;Stream;Stress;Structure of choroid plexus;Support System;Testing;Therapeutic;Tissues;Toxic effect;Toxin;Up-Regulation;vascular cognitive impairment and dementia;Ventricular;voltage;Waste Products;wasting;white matter;Woman

PROJECT_TITLE: Chronic Alcohol, Dementia, and CNS Fluid Homeostasis

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Lung;Prevention;Racial and Ethnic Minority Health Research;Sleep Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Currently used conventional metrics for sleep apnea assessment has many limitations including insufficient consideration of acute cardiovascular response to sleep apnea event. We propose to study whether the degree of acute blood pressure elevation associated with sleep apnea can help better identify people with higher cardiovascular risk and a more favorable response to therapy. We will also investigate whether there is a racial difference in the degree of blood pressure elevation, which may explain cardiovascular health disparity in African Americans.

PI_NAMEs: KWON, YOUNGHOON  (contact)

PROGRAM_OFFICER_NAME: TATAW-AYUKETAH, GLADYS OROCK

PROJECT_TERMS: Accounting;Acute;Address;Affect;African American;African American population;Ambulatory Blood Pressure Monitoring;Ancillary Study;Apnea;arterial stiffness;Biological Markers;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;caucasian American;Clinical;clinical decision-making;Clinical Trials;Continuous Positive Airway Pressure;cost efficient;Cross-Sectional Studies;Data;Decision Making;Devices;Disputes;Echocardiography;Effectiveness;EKG P Wave;Electrocardiogram;Enrollment;Evaluation;Event;Fingers;follow-up;Functional disorder;Goals;Health;Health Benefit;health disparity;Heart Atrium;Heart Rate;high risk population;Hospitals;Hypoxemia;improved;indexing;Individual;Infrastructure;innovation;Investigation;Left;Left Ventricular Dysfunction;Link;Measurement;Measures;Mechanics;Mediator;Methods;Monitor;monitoring device;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Nocturnal Hypertension;novel;Obstructive Sleep Apnea;Outcome;Parents;Participant;Pathway interactions;Patients;Persons;Phenotype;Physiologic pulse;Physiological;Polysomnography;Predisposition;Prevalence;Prognostic Marker;Prospective Studies;Race;racial difference;racial health disparity;recruit;Research Design;Resources;respiratory;response;Risk Factors;risk stratification;Sample Size;Sampling Studies;secondary outcome;Severities;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Specific qualifier value;Testing;Therapeutic;Time;treatment response;Ventricular;wearable device;Woman

PROJECT_TITLE: Sleep Apnea-Specific Nocturnal Blood Pressure Surge to Determine Cardiovascular Risks and Therapeutic Benefits in Patients with Obstructive Sleep Apnea

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Peripartum cardiomyopathy (PPCM) remains a major cause of maternal morbidity and mortality. Inhibition of prolactin with the dopamine agonist bromocriptine appeared to improve outcomes in previous clinical studies of PPCM; however, no randomized trial has been performed in a multi-racial North American cohort comparing bromocriptine against standard heart failure therapy. The purpose of the Randomized Evaluation of Bromocriptine Therapy for Peripartum Cardiomyopathy (REBIRTH) trial is to evaluate whether the addition of bromocriptine to standard heart failure therapy improves outcomes in women with PPCM.

PI_NAMEs: MCNAMARA, DENNIS M. (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Africa;African Women;American;biobank;Biological Markers;Breast Feeding;Bromocriptine;Cathepsins;Cessation of life;circulating biomarkers;Clinical;Clinical Research;cohort;Congestive Heart Failure;Control Groups;Disease;Disease-Free Survival;Dopamine Agonists;Echocardiography;Europe;Evaluation;Exclusion;German population;Guidelines;Heart failure;Heart Transplantation;Impairment;improved;improved outcome;Investigation;Lactation;Left;Left Ventricular Dysfunction;Left Ventricular Ejection Fraction;Left Ventricular Function;Live Birth;maternal morbidity;Maternal Mortality;Medical;multi-racial;Multicenter Trials;Myocardial;Newly Diagnosed;Outcome;outcome prediction;Pathogenesis;peripartum cardiomyopathy;placebo group;Placebos;Postpartum Period;Prediction of Response to Therapy;predictive marker;Pregnancy Complications;primary endpoint;Probability;Prolactin;Randomized;randomized placebo controlled trial;randomized trial;Recovery;Reporting;Role;secondary endpoint;South African;Suggestion;Therapeutic;Time;Treatment Failure;treatment group;trial comparing;United States;Ventricular;Ventricular Remodeling;Woman;women's outcomes

PROJECT_TITLE: (1/2) Randomized Evaluation of Bromocriptine in Myocardial Recovery Therapy for Peripartum Cardiomyopathy (REBIRTH)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Bacteria have evolved specialized secretion systems to secrete proteins or DNA from the bacterial cytoplasm into the surrounding medium or inside other target cells (either a eukaryotic or bacterial cell). This project seeks to define the structures of F plasmid encoded conjugation system of Escherichia coli, Helicobacter pylori Cag type IV secretion system and Porphyromonas gingivalis type IX secretion system to lay a foundation for development of intervention strategies aimed at blocking secretion function and disease progression.

PI_NAMEs: HU, BO  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Antibiotic Resistance;Architecture;Bacteria;Bacterial Adhesins;Bacterial DNA;Bacteroidetes;Biogenesis;Biological;cell envelope;Cells;Collaborations;Complex;computerized data processing;Cryo-electron tomography;Cytoplasm;Data Collection;Diameter;Disease Progression;DNA;Escherichia coli;F Factor;Foundations;gingipain;Helicobacter pylori;improved;In Situ;In Vitro;Infection;insight;Intervention;Legionella pneumophila;Medical;member;Membrane;Methods;Mobile Genetic Elements;nanomachine;novel;pathogen;Peptide Hydrolases;Periodontal Diseases;Pilum;Play;polymicrobial biofilm;Population;Porphyromonas gingivalis;Protein Secretion;Proteins;resistance gene;Resolution;Resources;Role;Sex Pili;Structure;Surface;System;system architecture;Therapeutic Intervention;therapy design;therapy development;Type IV Secretion System Pathway;Virulence;Virulence Factors;Visualization

PROJECT_TITLE: In Situ Architecture of Specialized Bacterial Secretion Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Brain Disorders

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Lithium is used as a ﬁrst line therapy for bipolar disorder and is promising for inhibiting development of dementia. Here we propose studies to understand how lithium affects one of its primary targets, protein kinases. Results from these studies will help improve predictions of patient responses to lithium-treatments, which remains a difﬁcult task.

PI_NAMEs: KLEIN, PETER S;VARMA, SAMEER  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;Advocate;Affect;Affinity;Base Pairing;Benchmarking;Binding;Binding Proteins;Biochemical;Bioinformatics;Biological;biophysical techniques;Biophysics;Bipolar Disorder;Blood;Calibration;Catalytic Domain;Chemicals;Chemistry;Cyclic AMP-Dependent Protein Kinases;Dementia;design;Development;dietary trace element;dosage;Dose;enzyme mechanism;enzyme model;Enzymes;Equilibrium;Experimental Designs;experimental study;Exposure to;Foundations;Free Energy;Future;Genes;Glycogen Synthase Kinase 3;glycogen synthase kinase 3 beta;Goals;Growth;Human;improved;In Vitro;in vivo;Individual;insight;Ions;Lithium;Maps;mechanical energy;Medical;Methods;Molecular;molecular mechanics;Mutagenesis;Mutagens;Mutation;mutation screening;Natural Selections;Outcome;Pathway interactions;patient response;Persons;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Physiological;Physiological Processes;Predisposition;Process;Protein Kinase;Proteins;Protocols documentation;Quantum Mechanics;Reaction;Resistance;Sampling;side effect;Signal Pathway;simulation;Site;Statistical Bias;Therapeutic;Time;Variant;Yeasts

PROJECT_TITLE: Molecular mechanisms of lithium action on kinases

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Procreation is a fundamental aspect of life that occurs when a sperm fuses with an egg. The disrupted formation of sperm and eggs, also known as germ cells, can result in infertility, spontaneous abortions, and birth defects, yet many aspects of germ cell development remain poorly understood. The goal of this proposal is to study the regulation of meiosis, a specialized cellular division that is required to produce haploid sperm and eggs, using mouse as the model organism, and discoveries made from this work will provide insights that are relevant to human health and fertility. !

PI_NAMEs: MIKEDIS, MARIA  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Aneuploidy;Binding;cancer therapy;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell transformation;Characteristics;chromosome missegregation;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;Cyclins;Defect;Development;Diploidy;DNA biosynthesis;egg;Event;Exhibits;Failure;Female;Fertility;Genes;Genetic Recombination;Germ Cells;Germ Lines;Goals;Haploidy;Health;Hela Cells;Human;Infertility;insight;Knowledge;Lead;Length;Life;male;Malignant Neoplasms;Mammals;Mediating;Meiosis;Meiotic Prophase I;Messenger RNA;Metaphase;Mitosis;Mitotic;Mitotic Prophase;model organism;Modification;Molecular;Molecular Abnormality;Mus;Organism;Outcome;Post-Transcriptional Regulation;posttranscriptional;predictive modeling;Pregnancy;premature;prevent;Preventive treatment;programs;Prophase;protein expression;Proteins;Publishing;Regulation;Research;RNA;Sampling;Series;sperm cell;Spontaneous abortion;Testing;Transcript;translation factor;Translational Repression;Translations;Ubiquitination;Up-Regulation;Work

PROJECT_TITLE: Establishment of the meiotic cell cycle program through post-transcriptional regulation by MEIOC and YTHDC2

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Kidney Disease;Patient Safety;Prevention

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE A major contributor to peri-operative morbidity and mortality experienced by patients undergoing on-pump cardiac surgery is ischemia reperfusion injury to the myocardium and other organs caused by aortic cross- clamping to isolate the heart from the systemic circulation. The proposed NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury (NACAM) trial will be a Phase 2, randomized, double-blind, placebo- controlled trial to evaluate the efficacy and safety of oral nicotinamide for the prevention of peri-operative myocardial injury in 304 patients. The primary endpoint in this study is the serum cardiac troponin T concentration Area Under the Curve (AUC) as a marker of myocardial injury, with secondary outcomes being incident acute kidney injury and the urinary quinolinate/tryptophan ratio as a mechanistic marker of impaired de novo NAD+ biosynthesis.

PI_NAMEs: POYAN MEHR, ALI  (contact)

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Adverse event;adverse outcome;Affect;Anabolism;Aorta;aortic valve replacement;Area Under Curve;Attenuated;Biogenesis;Biological Markers;biomarker validation;Cardiac;Cardiac Surgery procedures;cardioprotection;Cardiovascular system;Cell Respiration;cerebrovascular;Cessation of life;Characteristics;Circulation;Clinical;Clinical assessments;clinical effect;clinical efficacy;Clinical Trials;Closure by clamp;Comprehensive Health Care;design;Double-Blind Method;double-blind placebo controlled trial;Drug Kinetics;efficacy evaluation;Enrollment;Event;experience;follow-up;Future;genetic manipulation;Heart;high risk;high risk population;Homeostasis;hospital readmission;Hospitalization;Hour;Human;Impairment;improved;improved outcome;Incidence;Individual;Infrastructure;Injury to Kidney;insight;Integrated Delivery of Health Care;interest;Intervention;Investigation;Ischemia;Kidney;Knowledge;Length;Link;Measurement;Mediating;Medical;Medicine;Metabolic;Metabolism;Mitochondria;multidisciplinary;Mus;myocardial injury;Nature;Niacinamide;Nicotinamide adenine dinucleotide;novel;older adult;Operative Surgical Procedures;Oral;Oral Administration;Organ;organ injury;Outcome;Pathway interactions;patient population;Patients;Perioperative;perioperative morbidity;perioperative mortality;Phase;phase 3 study;phase I trial;Pilot Projects;Population Heterogeneity;Postoperative Period;PPAR gamma;pre-clinical;preclinical study;Predisposition;Prevalence;prevent;Prevention;Preventive therapy;primary endpoint;Procedures;Production;protective effect;Protocols documentation;Pump;quinolinate;Randomized;randomized placebo-controlled clinical trial;receptor;renal ischemia;Reperfusion Injury;Risk;Safety;safety study;secondary endpoint;secondary outcome;Serum;sociodemographics;Special Event;Stress;stress reduction;stressor;Subgroup;Supplementation;System;Techniques;Testing;Thoracic Surgical Procedures;tissue biomarkers;tissue injury;Tissues;Translating;Troponin T;Tryptophan;urinary;Vasoconstrictor Agents;vitamin analog

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Interstitial Cystitis;Mental Health;Mental Illness;Urologic Diseases

PHR: PROJECT NARRATIVE Understanding how underlying disease mechanisms in overactive bladder contribute to the development of urinary symptoms, including urinary urgency and urgency incontinence, is highly relevant to public health. The proposed, interdisciplinary research that includes experts in Urology, Psychology, and chronic pain research will contribute to the fundamental knowledge of how psychology relates to bladder sensitivity and to psychological burdens in people with overactive bladder and how this can be measured effectively. This will allow future studies in which interventions to improve bladder health and incontinence can be implemented and outcomes recorded, with the goal of improving bladder health.

PI_NAMEs: MCKERNAN, LINDSEY COLMAN;SEBESTA, ELISABETH M (contact)

PROGRAM_OFFICER_NAME: REYNOLDS, WILLIAM STUART

PROJECT_TERMS: Acute;acute stress;Adopted;Affect;Animals;Anxiety;anxiety symptoms;Area;Behavior;Behavioral;behavioral impairment;Bladder;chronic pain;Clinical Trials;Containment;Controlled Study;coping;Coping Behavior;Cross-Sectional Studies;Development;diaries;Discipline;Disease;Distress;Ecological momentary assessment;Electronics;Esthesia;Frequencies;Future;generalized anxiety;Generalized Anxiety Disorder;Genitourinary system;Goals;Health;Human;Hydration status;Hypersensitivity;Impairment;improved;Incontinence;Individual;innovation;Interdisciplinary Study;Intervention;Knowledge;Laboratories;Learning;Left;Life;Link;Liquid substance;Maps;Measures;Mediating;men;meter;Methods;micturition urgency;Modeling;Nocturia;novel;Oral;Outcome;Overactive Bladder;Pain Research;Pathway interactions;Patients;Pattern;perceived stress;personalized care;Persons;Physiological;Procedures;Process;prospective;psychologic;Psychological Factors;Psychological Stress;psychological stressor;Psychology;Public Health;Quality of life;Research;response;Role;Sampling;Scientific Advances and Accomplishments;self help;Self Management;Side;Strategic Planning;Stress;stress reactivity;stress symptom;Symptoms;Testing;Time;Travel;urinary;Urinary Incontinence;Urology;Woman

PROJECT_TITLE: Stress and Anxiety Effects on Overactive Bladder: A Controlled Study

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: POTSDAM

ORG_DEPT: BIOLOGY

ORG_NAME: CLARKSON UNIVERSITY

PHR: Project Narrative Biological patterning relies on the coordination of cell-cell communication events across large and small distances, and defects in patterning can lead to human disorders and disease. Cytonemes are one example of an active cell process that coordinates cell signaling for many patterning events during vertebrate and invertebrate development. The goal of this work is to understand both how cytonemes are regulated at the cellular scale and how they contribute to the overall progression of patterning.

PI_NAMEs: HUNTER, GINGER LORAINE (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Actins;Address;Behavior;Biological;Biological Models;cell behavior;Cell Communication;Cell Physiology;Cell Shape;Cells;Chest;Cytoskeleton;Defect;Development;Developmental Process;Disease;Dorsal;Drosophila genus;Drosophila melanogaster;Epithelial Cells;Event;Filopodia;gene induction;Genetic;Goals;Heterogeneity;Homeostasis;Human;interest;Invertebrates;Knowledge;Lateral;Length;Limb structure;Maintenance;Mediating;Microscopy;Morphogenesis;neural plate;notch protein;Pattern;programs;Regulation;Research;Signal Transduction;Spottings;stem cell niche;Surface;Tissues;Work

PROJECT_TITLE: Mechanisms of cellular morphogenesis that coordinate signaling during tissue patterning

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Organism survival is dependent on proper tissue and organ function, which requires a significant amount of energy to ensure correct organ-to-organ communication and maintenance of tissue stem cells. We propose to take advantage of the excellent model my lab has established using transcription factors and stem cells in the fruit fly ovary to understand how inter-organ communication maintains tissue behavior. Our work will generate new insight into how disruption of organ communication might lead to tissue abnormalities in many organisms, including humans.

PI_NAMEs: WEAVER, LESLEY NICOLE (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Adipocytes;Adult;adult stem cell;Behavior;behavior influence;carbohydrate metabolism;cell behavior;Cell Lineage;Cell Maintenance;cell type;Cells;Cellular biology;Cellular Metabolic Process;Communication;Cyst;Distal;Distant;Drosophila genus;Drosophila melanogaster;egg;Endocrine disruption;Ensure;Fatty Acids;Foundations;Future;Genetic;Genetic Transcription;Germ Lines;germline stem cells;Goals;Growth;Hepatocyte;Homeostasis;Hormones;Human;insight;Ligand Binding Domain;Maintenance;Mediating;Metabolism;Modeling;Muscle;next generation sequencing;Nuclear Receptors;Oogenesis;Organ;Organ failure;Organism;Ovary;oxidation;Peripheral;Physiological;Physiology;Play;programs;Receptor Signaling;Regulation;repaired;Research;Role;Signal Transduction;stem cell differentiation;stem cell survival;stem cells;Steroids;tissue stem cells;Tissues;transcription factor;Work

PROJECT_TITLE: Regulation of tissue stem cell lineages by nuclear receptor signaling


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARATIVE African-Americans are disproportionately burdened by disrupted/misaligned circadian rhythms, disturbed sleep and specific sleep disorders, such as sleep apnea, which is likely contributing to the high burden of adverse cardiometabolic health in this population; yet the underlying determinants are unknown. The proposed study investigates the impact of multilevel socio-environmental factors (household and neighborhood-level) on psychosocial factors, circadian and sleep disruption, and subsequently adverse cardiometabolic health in African-Americans.

PI_NAMEs: JOHNSON, DAYNA  (contact)

PROGRAM_OFFICER_NAME: ALFINI, ALFONSO JOSEPH

PROJECT_TERMS: actigraphy;Adult;Adverse effects;Affect;African American population;Air;Air Pollution;American;Apnea;arterial stiffness;Behavioral;Biochemical Markers;Biological Rhythm;Blood Glucose;Blood Pressure;Buffers;cardiometabolism;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Characteristics;circadian;Circadian desynchrony;Circadian Dysregulation;Circadian Rhythms;Clinic;Clinical;cohort;Controlled Environment;coping;Data;design;Diabetes Mellitus;diaries;Disadvantaged;Disparity;effective intervention;Electronics;Environment;environmental adaptation;Environmental Exposure;Environmental Risk Factor;Goals;Health;Home;Hour;Household;Housing;Hypertension;Individual;Inflammation;inflammatory marker;Intervention;Knowledge;Laboratory Study;Light;Link;Measurement;Measures;Melatonin;Metabolic dysfunction;Metabolism;Morbidity - disease rate;mortality;Neighborhoods;Noise;Obesity;Outcome;Physiological Processes;Pollution;Polysomnography;Population;prevent;protective factors;Proxy;Psychosocial Factor;Psychosocial Stress;Research;resilience;Resources;Risk;Safety;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;sleep health;Social Environment;Socioeconomic Status;socioeconomics;socioenvironmental factor;System;Technology;Testing;Time;urban area;Variant;ventilation

PROJECT_TITLE: Multilevel Determinants of Circadian Factors and Sleep Disruption: Implications for Cardiometabolic Health Among African-Americans


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

PHR: Project Narrative Despite substantial advances in our ability to collect genomic data and catalog genetic variation, understanding how the collection of proteins in an organism create phenotype is difficult to determine because phenotype emerges from a hierarchy of protein interactions: proteins interact to create complexes, pathways, and phenotypes. To date, no method exists to elucidate a hierarchy of protein interactions. Using bacteria as a model, this proposal seeks to develop and validate a novel statistical approach that defines hierarchically layered networks of protein interactions that describe the emergence of complex phenotype from a `parts-list' of proteins from genome sequence alone. In the emerging era of `big-data' in biology, such an approach substantially aid in relating genotype with cellular behavior, and may be a generally effective framework towards parsing high-content, complex biological data.

PI_NAMEs: RAMAN, ARJUN  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TITLE: Using co-evolution to understand the emergence of bacterial phenotype from proteome variation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Digestive Diseases;Infectious Diseases

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: Project Narrative: Early sensing of mucosal barrier damage by migratory group 2 innate lymphoid cells (iILC2) during helminth infection is important for the induction of type-2 immunity and barrier repair. Understanding the physiologic origin, the mechanism of migration, and the contribution to the long-term, tissue-resident ILC2 population is likely to reveal the importance of this unique iILC2 cell in shaping the immune landscape of the lung after repeated helminth infection.

PI_NAMEs: REINHARDT, RICHARD LEE (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Animals;Appearance;Blocking Antibodies;Bone Marrow;Cell Adhesion Molecules;Cell Compartmentation;Cell Lineage;cell motility;Cells;Cellular biology;chemokine receptor;CXCR4 gene;CXCR6 gene;cytokine;Data;Dependence;Endothelium;Epithelium;first responder;Genes;Genomics;helminth infection;Helminths;Heterogeneity;Hookworm Infections;Human;Image;Immigration;Immune;Immune response;Immunity;in vivo;Infection;Inflammatory;innovation;Integrins;Interleukin-13;Interleukin-4;Interleukin-5;intestinal epithelium;Intestines;Knowledge;Lung;Lymphoid Cell;Maintenance;Maps;Mediating;migration;Mucositis;Mucous Membrane;Mus;Nature;Persons;Phenotype;Physiological;Play;Population;Process;Productivity;Publications;repaired;Reporter;Role;self-renewal;Shapes;Slice;Small Intestines;Soil;Source;sphingosine 1-phosphate;stem;stem cells;System;Testing;Tissues;transmission process;Work;World Health Organization

PROJECT_TITLE: The Origin and Role of Pulmonary ILC2 Subsets in Anti-Helminth Immunity

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative The extracellular matrix (ECM) is a complex assembly of hundreds of proteins and a critical regulator of cancer progression. Compared to other proteins, ECM proteins are understudied, mainly because of challenges posed by their chemical properties (large size, insolubility, broad dynamic range). The proposed project will harness these challenges and focus on the development of transformative proteomic technologies to study with great depth the protein composition and architecture of the extracellular matrix of cancers. By doing so, we believe we will be able to better understand the mechanisms leading to cancer progression and thus identify novel proteins that can either better predict cancer outcome or be targeted therapeutically to treat cancers.

PI_NAMEs: GAO, YU ;NABA, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acute;Adopted;Advanced Malignant Neoplasm;Amino Acid Sequence;anti-cancer research;Architecture;Area;Benchmarking;Binding;Biochemical;cancer proteomics;Categories;Cell Physiology;Cessation of life;chemical property;Communities;Complex;Computer software;cost;crosslink;Data;Data Set;Databases;Development;Digestion;Disease;DNA Sequence Alteration;Early Diagnosis;Enzymes;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Extracellular Structure;Fibroblasts;Future;Generations;Genetic study;glycosylation;Growth Factor;improved;in silico;Individual;innovation;insight;instrumentation;Knowledge;Malignant Neoplasms;Maps;Mass Spectrum Analysis;matrigel;Mediating;medical specialties;Metabolic;Methods;Modality;Modeling;Motility;Neoplasm Metastasis;neoplastic cell;new technology;Normal tissue morphology;novel;novel therapeutics;Outcome;Pathway interactions;Patient-Focused Outcomes;Peptide Hydrolases;Peptide Mapping;Peptides;Performance;Play;Post-Translational Protein Processing;predictive modeling;predictive signature;Preparation;prevent;Prognostic Marker;Proliferating;Property;protein data bank;Protein Denaturation;protein folding;protein function;Protein Isoforms;protein structure;Proteins;Proteolysis;Proteomics;Protocols documentation;Publishing;Reagent;Research;Research Personnel;Resistance development;Resources;Role;Sampling;searchable database;Signal Transduction;Structural Protein;Structure;targeted treatment;Techniques;Technology;therapeutic target;three dimensional structure;three-dimensional modeling;Time;Tissues;tool;translational potential;tumor;tumor microenvironment;tumor progression;Tumor stage;Tumor Tissue;United States;Vial device;Visualization;Work

PROJECT_TITLE: Enhanced mass-spectrometry-based approaches for in-depth profiling of the cancer extracellular matrix


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Diabetes;Genetics;Human Genome

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE  The explosion of genomic and biological information is poised to transform the practice of medicine, but its impact will be determined by the clinician’s ability to absorb, assimilate and translate this body of knowledge. Dr. Florez has dedicated himself to advance genomic and metabolomic discoveries in type 2 diabetes and related metabolic traits, and previously generated useful resources and established a training pipeline. He now seeks to continue attracting and mentoring a cadre of highly trained investigators who will be empowered to lead the application of these findings to the clinical setting, by 1) expanding an infrastructure of pertinent genomic and physiologic datasets, 2) maintaining a rigorous training pipeline embedded in a cutting-edge clinical and scientific environment, and 3) guiding the investigation of clinically relevant hypotheses.

PI_NAMEs: FLOREZ, JOSE CARLOS (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: absorption;Acceleration;analytical tool;Attention;Award;Big Data;Biological;Blood Vessels;Cardiometabolic Disease;cardiometabolism;Cardiovascular system;Clinic;Clinical;clinical investigation;clinical translation;clinically actionable;clinically relevant;Collaborations;complex data;Data;Data Analytics;Data Set;Dedications;Development;Diabetes Mellitus;Disease;Dizziness;empowerment;Endocrine;Environment;Explosion;Funding;General Hospitals;Genetic;genome repository;genomic data;Genomic medicine;Genomics;Goals;Health;Human;improved;improved outcome;Individual;information gathering;Infrastructure;Institution;International;Investigation;investigator training;Knowledge;Knowledge Portal;Lead;Life;Massachusetts;Medical;medical schools;Medicine;member;Mentors;Metabolic;metabolic phenotype;metabolomics;Mining;model organism;Non-Insulin-Dependent Diabetes Mellitus;outcome prediction;Participant;patient oriented;patient oriented research;Phenotype;Physiological;Positioning Attribute;Preventive;Productivity;professor;Public Health;public health intervention;Research;Research Personnel;Resources;Scientist;skills;success;System;Technology;Testing;Therapeutic;Time;Training;training opportunity;trait;Translating

PROJECT_TITLE: Mentoring Investigators on the Clinical Translation of Cardiometabolic Genetic Discoveries

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project is designed to establish academic and continuing education (CE) courses in emerging technologies specific to site biological/infectious agent safety. This collaborative, multidimensional educational experience will facilitate not only skills development and field application, but also create opportunities for innovative, cross-disciplinary research experiences and curriculum development on emerging technologies. The specific aims of this project are the successful development, implementation, and evaluation of 1) a continuing education (CE) certificate program focused on site biological and infectious agent health and safety, 2) a collaborative research-oriented academic course, and 3) a field practitioner course that utilizes the research products from the research-oriented academic course emphasizing emerging technologies in biological and infectious agent health and safety, offered collaboratively between the partnering institutions.

PI_NAMEs: HANDY, RODNEY G;SLEETH, DARRAH KAYE (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: adaptive learning;Address;animation;Bacteria;Biological;Biological Products;Biomedical Engineering;California;certificate program;Certification;Chemicals;Collaborations;Consultations;Continuing Education;course development;COVID-19;curriculum development;design;Development;Devices;Dimensions;Discipline;E-learning;Education;education research;Emerging Technologies;Enrollment;Evaluation;experience;Faculty;Future;Genetically Modified Organisms;Goals;graduate school;hazard;Hazardous Waste Operations and Emergency Response;Health;Health Technology;Hour;Hybrids;improved;Industrial Health;Industrialization;industry partner;Infectious Agent;innovation;Institution;Instruction;inter-institutional;Interdisciplinary Study;Joints;learning ability;Learning Module;member;Mind;Montana;Motion;new technology;Occupational Health;occupational health/safety;Outcome;Parasites;Participant;Pathogenicity;Persons;Program Evaluation;programs;remediation;Research;Research Personnel;Research Project Grants;Resolution;Safety;Site;skill acquisition;Students;System;Techniques;Technology;Texas;Time;tool;Topical application;Training;Training and Education;undergraduate student;Universities;Utah;Virus;Work

PROJECT_TITLE: Biological Hazard Site Training in Emerging Technologies (BioSTET) for Health and Safety


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE. People with Down syndrome (DS) display profound immune dysregulation, which could have myriad negative impacts on their health, including the development of various immune and neurological disorders. Multiple lines of evidence indicate that hyperactivation of interferon (IFN) signaling drives immune dysregulation in DS. This proposal aims to complete a clinical trial in adults with DS and immune skin conditions, using a pharmacological inhibitor of IFN signaling, which is expected to have multidimensional therapeutic benefits in this population.

PI_NAMEs: BRUCKNER, ANNA LEE;ESPINOSA, JOAQUIN M. (contact);GURNEE, EMILY ;RACHUBINSKI, ANGELA LYNN

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adult;adverse event monitoring;Affect;Age;Alopecia Areata;Alzheimer's Disease;Atopic Dermatitis;Autoantibodies;Autoimmune Diseases;autoimmune thyroid disease;Automobile Driving;Blood specimen;Brain;Celiac Disease;cell type;Cells;Chronic;Clinical;Clinical Management;Clinical Trials;Cognition;cognitive function;cytokine;Dermatologist;Development;Dimensions;Disease;Down's Syndrome;Exclusion Criteria;follow-up;Future;Genes;Health;Hidradenitis Suppurativa;Homeostasis;Hyperactivity;Hypersensitivity;Immune;Immune System Diseases;immunomodulatory strategy;improved;Individual;Inflammatory;inhibitor;Insulin-Dependent Diabetes Mellitus;Interferon Activation;Interferon Receptor;Interferons;JAK1 gene;Kynurenine;Leukocytes;Life Expectancy;Link;Malignant Neoplasms;Measures;metabolomics;multidisciplinary;Myelofibrosis;Nervous System Disorder;neuroinflammation;neurotoxic;novel;open label;Outcome;overexpression;Pathology;Pathway interactions;Persons;pharmacologic;Phase II Clinical Trials;phase III trial;Phosphotransferases;Plasma;Polycythemia Vera;Population;prevent;primary endpoint;Process;Production;Proteomics;Psoriasis;Psoriatic Arthritis;Quality of life;Quality of Life Assessment;recruit;Reporting;response;Rheumatoid Arthritis;Role;Safety;safety assessment;secondary endpoint;side effect;Signal Pathway;Signal Transduction;Skin;social implication;Solid;Testing;Therapeutic;Transcriptional Activation;transcriptome;Tryptophan;Ulcerative Colitis;Vitiligo

PROJECT_TITLE: JAK Inhibition in Down Syndrome


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: DENTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NORTH TEXAS

PHR: Project Narrative The physical properties of the tissue environment play an important role in numerous diseases/disorders spanning cancer, pulmonary fibrosis, and hypertension. Changes in these physical properties alter how nanotherapeutics interact with cells, while creating new opportunities for targeting diseased tissue. This proposal seeks to understand how extracellular stiffness and dynamic forces alter nanoparticle efficacy, and then leverage these propertes to design novel nanoparticles that have improved targeting and trafficking in dysfunctional tissue.

PI_NAMEs: MECKES, BRIAN R (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TITLE: Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The sexual stages of Toxoplasma gondii contribute to high toxoplasmosis prevalence and severe disease in immunocompromised individuals. Our lab discovered that the fatty acid linoleic acid enables growth of T. gondii sexual stages outside the definitive cat host. The proposed work will help us understand how linoleic acid affects host and parasite to support T. gondii sexual development, with the goal of using that knowledge to prevent T. gondii transmission.

PI_NAMEs: DAVIS, NICOLE MARIE (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Ablation;Acids;Affect;Agreement;Animal Experimentation;asexual;automated image analysis;Biological Models;Biology;Brain;Cause of Death;Cell Culture Techniques;Cell Differentiation process;cell type;Cells;companion animal;Data;Development;Disease;Environment;Epigenetic Process;Ethics;experimental study;Eye;Family Felidae;Fatty Acids;Felis catus;foodborne illness;Genes;Genetic Transcription;Goals;Growth;HDAC3 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Histones;Human;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Integration Host Factors;intestinal epithelium;Intestines;knock-down;Knowledge;Linoleic Acids;Lipids;Literature;Mammals;Measures;Mediating;Modeling;Modification;Molecular;mouse model;Mus;Oocysts;overexpression;Parasites;permissiveness;Polyunsaturated Fatty Acids;Prevalence;prevent;Production;Proteins;Research;response;Role;Seroprevalences;sex;Sex Differentiation;Sexual Development;Signal Pathway;Small Interfering RNA;Testing;Therapeutic;tissue culture;Toxoplasma gondii;Toxoplasmosis;transmission process;United States;vaccine development;Work

PROJECT_TITLE: Mechanistic analysis of Toxoplasma gondii sexual development in tissue culture and mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pain Research;Patient Safety

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The use of anesthesia to block patients’ traumatic experiences during surgery is one of the most remarkable innovations of mankind, yet how these special drugs affect the brain to disrupt conscious experience is not fully understood. Using advanced imaging and other real-time measures of brain function in human subjects, the proposed neuroscience research will determine how and where in the brain different anesthetics work to prevent the experience of pain and to block formation of unwanted memory. Understanding how complex interconnected brain systems are affected by different anesthetics, particularly when used together, will improve the ability to provide the optimal combination of medications to patients needing anesthesia for otherwise painful procedures.

PI_NAMEs: VOGT, KEITH MICHAEL (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Address;Adult;Affect;Amnesia;Analgesics;Anesthesia procedures;Anesthesiology;Anesthetics;arm;Behavior;Behavioral;Biomedical Engineering;Brain;Clinical;clinical practice;Clinical Trials;cognitive function;cognitive task;Combination Medication;Complex;conditioned fear;Conscious;Data;Data Analyses;Dexmedetomidine;Dose;drug action;Drug Interactions;Electroencephalography;Engineering;Ensure;Environment;experience;Fentanyl;Foundations;Functional Magnetic Resonance Imaging;Goals;heart rhythm;Human;human subject;Image;improved;Individual;innovation;Investigation;Ketamine;Knowledge;Lidocaine;Magnetic Resonance Imaging;Measures;Memory;Midazolam;Modeling;multimodal data;neural;neural correlate;neuroimaging;Neurosciences;Neurosciences Research;Operative Surgical Procedures;Pain;pain processing;pain relief;Patients;Perioperative;Pharmaceutical Preparations;Pharmacology;Physicians;Placebo Control;Polypharmacy;prevent;Procedures;Productivity;programs;Propofol;Psychology;Randomized;Research;response;sevoflurane;Single-Blind Study;System;Time;trial comparing;volunteer;Work

PROJECT_TITLE: Neuroimaging to identify the neural correlates of anesthetic and analgesic action in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Hypertension;Kidney Disease;Nutrition

PHR: Contemporary diets are rich in sodium chloride and low in potassium, which in combination can cause salt- sensitive high blood pressure due to maladaptive mechanisms that originate in the kidney. A family of enzymes called WNK kinases participates in this process. In this project, we will explore a novel mechanism that organizes and activates WNK kinases in salt-handling kidney tubule cells as they shrink during stress. The proposed studies will advance our basic understanding of how WNK kinases function in health and disease.

PI_NAMEs: RODAN, AYLIN RACHEL;SUBRAMANYA, AROHAN R (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Amplifiers;Apical;Behavior;biological adaptation to stress;Biology;blood pressure regulation;Bypass;C-terminal;Cations;CCL14 gene;Cell Line;Cell Volumes;cell water;Cells;Charge;chloride-cotransporter potassium;Chlorides;Coupled;Crowding;Diet;Disease;disease-causing mutation;Distal;Distal convoluted renal tubule structure;Drosophila genus;Environment;Enzymes;Epithelial Cells;Epithelium;extracellular;falls;familial hyperkalemic hypertension;Family;Genes;Health;Homeostasis;hyperkalemia;Hypertension;Hypokalemia;imaging modality;innovation;Ion Transport;Ionic Strengths;Ions;Kidney;Knowledge;Learning;lens;Liquid substance;live cell imaging;Lysine;Malpighian Tubules;Measures;Mediating;Membrane;Modeling;Molecular;mouse model;Mus;mutant;Nephrons;novel;Pathway interactions;Phase;Phase Transition;Phosphorylation;Phosphotransferases;Physical condensation;Physiological;Physiology;Potassium;Process;Protein Isoforms;Proteins;Recovery;Regulation;renal epithelium;Renal tubular acidosis;Renal tubule structure;Reporting;response;Role;salt sensitive;salt sensitive hypertension;scaffold;sensor;Signal Pathway;Signal Transduction;Sodium;Sodium Chloride;Stress;Structure;symporter;Testing;thiazide;Thinking;Tubular formation;Work

PROJECT_TITLE: Control of the Renal WNK Signaling Pathway by Phase Transitions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-W(05)]