NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cerebrovascular;Neurosciences;Sleep Research

ORG_CITY: PROVIDENCE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Healthy behavior requires the integration of many signals, such as body signals that report to the brain our current needs (e.g., hunger, thirst) as well as Circadian Cycles that help us meet needs on a longer time scale (e.g., sleep) and the activity of pathways such as the Ventral Tegmental Area (VTA) so current choices and longer-term learning reflect what brain systems view as important or rewarding. A new discovery described in my Preliminary Data shows a new connection between these signals. VTA activity can open the blood-brain barrier, allowing greater access of body molecules to the brain, but only at times when high-quality body-state information is most important. I will systematically test the closely-related hypotheses that VTA dynamics (Aim I) and their impact on both the BBB (Aim II) and behavior output (Aim III) peak early in the active (dark) phase and then diminish, fitting their putative behavioral role.

PI_NAMEs: TURNER, KEVIN LAWRENCE (contact)

PROJECT_TERMS: Action Potentials;Albumins;Arousal;awake;Axon;Behavior;Behavioral;Behavioral Paradigm;Biological;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier permeabilization;Brain;brain health;Calcium Signaling;Calcium Spikes;career;circadian;Circadian Rhythms;Circulation;Cognitive;cognitive change;Communication;computer framework;Computer Models;Corpus striatum structure;Cues;Data;Disease;Distal;Dorsal;early life adversity;Environment;Estrogens;Event;experience;Exposure to;Failure;Fiber;frontal lobe;Goals;Gonadal Steroid Hormones;Health;high dimensionality;high reward;Hormonal;Hunger;Image;Immune signaling;Impulsivity;Insulin;Knowledge;Laboratories;Learning;Literature;Measures;Medial;Metabolic;Mus;Neocortex;neural;neuroimaging;neurotransmission;optogenetics;Outcome;Output;Pathway interactions;Pattern;Performance;Permeability;Phase;Photometry;Postdoctoral Fellow;pressure;Probability;Prosencephalon;Recording of previous events;Regulation;Reporting;Research;Research Personnel;Resolution;response;Rewards;Risk;Role;Signal Transduction;Signaling Molecule;Sleep;Sleep Stages;somatosensory;Source;Stimulus;System;Testing;Thirst;Time;Training;transmission process;two photon microscopy;two-photon;Variant;Ventral Tegmental Area;Work

PROJECT_TITLE: Circadian Control of the VTA: Neural and BBB Dynamics


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on generating novel patient-derived models of primary and metastatic hormone receptor positive (HR+) breast cancer. HR+ breast cancer is the most common subtype of breast cancer (~70%), and despite available treatments, 30% of patients’ tumors recur, at which point the tumors are often metastatic and treatment resistant. Our proposal focuses on generating more ethnically diverse models of HR+ disease, and will use these models to target drivers of treatment resistance in metastatic and relapsed HR+ tumors.

PI_NAMEs: MURANEN, TARU ELIISA (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;African American;Agonist;Biological Models;Breast Cancer Cell;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Treatment;cancer recurrence;CDK4 gene;Cessation of life;Citric Acid Cycle;Clinical;clinically relevant;Coculture Techniques;Core Biopsy;Coupled;Data;Disease;Ecosystem;Elements;ethnic diversity;Ethnic Origin;exome sequencing;Fibroblasts;Goals;Growth;Growth Hormone Receptor;GTP-Binding Proteins;Hispanic;Histologic;hormone receptor-positive;hormone resistance;improved;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;innovation;knock-down;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Methods;Modeling;Molecular;Newly Diagnosed;novel;novel therapeutic intervention;Organoids;outcome disparities;Pathway interactions;patient population;Patients;Preclinical Testing;Protocols documentation;Public Health;Race;racial diversity;receptor;Recurrence;Recurrent tumor;Relapse;Research;Resistance;response;Role;Signal Transduction;Site;standard of care;success;Succinates;Techniques;Technology;Testing;Therapeutic;therapeutic target;therapy resistant;Time;tool;transcriptome sequencing;treatment response;treatment strategy;tumor;Tumor Biology;tumor microenvironment;Tumor stage;Underrepresented Minority;Work

PROJECT_TITLE: Using patient-derived co-culture models of breast cancer to develop new treatment strategies targeting succinate signaling.

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


ADMINISTERING_IC: AT

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Neurosciences;Pain Research;Physical Activity

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The scientific basis underlying yoga’s therapeutic benefits for chronic pain is not well understood. Persistent post-surgical pain (PPSP) is a widespread chronic pain condition with few effective treatments. This study will begin to evaluate the potential for yoga to manage the constellation of symptoms associated with PPSP and explore the role of inflammation and other processes in PPSP’s resolution.

PI_NAMEs: MUÑOZ-VERGARA, DENNIS  (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Absence of pain sensation;Adherence;Analgesics;Area;Articular Range of Motion;associated symptom;Attention;Biological;Biological Process;Brief Pain Inventory;career development;central pain;central sensitization;Cesarean section;Characteristics;Cholecystectomy;Chronic;chronic pain;chronic pain management;Chronic pain syndrome;chronic painful condition;chronic widespread pain;Clinical;Clinical Research;clinical translation;Cognitive;Conduct Clinical Trials;Connective Tissue;Consensus;Control Groups;cytokine;Data;debilitating pain;design;Development;Dimensions;Education;education planning;effective therapy;eligible participant;Emotional;Endocannabinoids;endogenous cannabinoid system;Enrollment;Environment;Evaluation;experience;Face;Foundations;Functional disorder;Future;Goals;Health education;Incidence;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Institution;instructor;interest;Interleukin-6;Intervention;intervention delivery;Journals;K-Series Research Career Programs;Link;Manuals;Mediator;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;method development;mind/body;Modeling;Movement;multidisciplinary;National Center for Complementary and Integrative Health;nerve damage;nerve injury;novel;Operative Surgical Procedures;Opioid;Outcome;Outcome Measure;Pain;Pain Measurement;pain outcome;pain patient;Participant;Pathologic;Patient-Focused Outcomes;Patients;Peer Review;Peripheral;peripheral pain;Persistent pain;Persons;Pharmacological Treatment;Physiological;Play;Positioning Attribute;Postoperative Pain;Postoperative Period;pre-clinical;preclinical study;prevent;primary outcome;Procedures;Process;programs;Protocols documentation;Psychophysics;psychosocial;Publishing;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;repaired;Research;Research Support;Resolution;Resources;retention rate;Risk;Role;Safety;Science;Sensory;side effect;Skin injury;sound;Sternotomy;Stretching;Structure;Surgical Injuries;symposium;Testing;Therapeutic;Therapeutic Intervention;Thoracotomy;Tissues;Training;translational clinical trial;Translational Research;translational scientist;Translational trial;United States;Validation;whole health;Work;Yoga

PROJECT_TITLE: Yoga for Persistent Post-Surgical Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 AM (05)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Genetics;Hematology;Infectious Diseases;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse

ORG_CITY: ROOTSTOWN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NORTHEAST OHIO MEDICAL UNIVERSITY

ORG_STATE: OH

PHR: Narrative Alcohol abusers are susceptible to infectious diseases, particularly septicemia, which causes enormous health and economic burdens in the United States. Many alcoholic patients with severe bacterial infection are present with leukopenia, which is frequently fatal. This project investigates the mechanisms underlying alcohol-induced impairment of immune defense function, which will help identify therapeutic targets for effective treatment of alcoholic patients with severe bacterial infection.

PI_NAMEs: ZHANG, PING  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Agranulocytosis;Alcohol abuse;alcohol abuser;alcohol exposure;Alcoholic Intoxication;Alcohols;Bacterial Infections;Binding Proteins;Binding Sites;Bone Marrow;CD34 gene;CDK4 gene;Cell Nucleus;Cells;Chronic;Communicable Diseases;Complex;Cyclin D1;cytokine;Defect;defense response;Development;Economic Burden;effective therapy;Escherichia coli;Exhibits;experimental study;Exposure to;Family;Fatal Outcome;Gene Activation;Gene Expression;Genes;granulocyte;Guanosine Triphosphate Phosphohydrolases;guanylate;Health;Hematopoietic;Hematopoietic stem cells;Host Defense;Human;Immune;Immune system;Immunocompromised Host;Impairment;improved;In Vitro;Infection;inhibitor;Interferon Suppression;Interferon Type II;Investigation;JUN gene;Knock-out;knockout gene;Knowledge;Leukopenia;Lipopolysaccharides;macromolecule;MAPK8 gene;Marrow;member;Messenger RNA;Molecular Conformation;monocyte;Mus;neutrophil;novel therapeutic intervention;Nuclear;pathogenic bacteria;Pathway interactions;Patients;Phagocytes;Pilot Projects;precursor cell;Predisposition;problem drinker;Production;Proliferating;Promoter Regions;Proteins;Regulation;response;Risk;Role;Sepsis;septic;Septicemia;Signal Transduction;single-cell RNA sequencing;stem cell proliferation;Stimulus;System;Testing;therapeutic target;Time;TLR4 gene;transcriptome sequencing;United States;Up-Regulation

PROJECT_TITLE: Alcohol impairs the HSPC response to septic infection

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Due to their tremendous human and financial burden, Alzheimer’s disease and related dementias (ADRD) have risen to the forefront of the United States public health agenda. Diversification of ADRD researchers can lead to an increase in the participation of racially and ethnically diverse and other underrepresented populations in aging and ADRD research and improve the efficacy of programs and services. This award will provide necessary support and time to deepen understanding for how to meaningfully integrate community engagement, health communication, and dissemination and implementation science into a holistic, equity- driven, and interdisciplinary training for underrepresented researchers advancing the science of ADRD.

PI_NAMEs: FRIEDMAN, DANIELA B. (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;adverse childhood events;African American;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;American;Area;Attention;Award;Awareness;Black American;Cardiovascular system;career;Chronic Disease;Cognitive;Cognitive aging;Communication;Communities;community based participatory research;community engagement;Community Health;curriculum development;Death Rate;Disabled Persons;Disadvantaged;disadvantaged background;Discipline;Disparity;Disparity population;disparity reduction;Dissemination and Implementation;dissemination science;Educational workshop;Equity;ethnic diversity;Ethnic Population;Evaluation;evidence base;Faculty;faculty mentor;Financial Hardship;food insecurity;Funding;Goals;Health;health care availability;health communication;Health Disparities Research;health disparity;health equity;Hispanic;Historically Black Colleges and Universities;Human;human old age (65+);implementation framework;implementation science;improved;Individual;Infrastructure;innovation;Institutionalization;Leadership;Medical;member;Mentors;Mentorship;Methods;Minority;minority communities;minority health;minority investigator;Minority Participation;National Institute on Aging;neighborhood disadvantage;older adult;Outcome;Policies;Population Heterogeneity;Prevalence;Prevention;professor;programs;Public Health;Quality of life;racial diversity;racial population;racism;Registries;Research;Research Assistant;Research Methodology;Research Personnel;Research Training;Resources;Risk Reduction;Schools;Science;Scientist;Senior Scientist;Services;skills;social factors;social health determinants;South Carolina;Students;tenure track;Time;Training;Training Programs;Underrepresented Populations;United States;Universities;Visit;Woman;Work

PROJECT_TITLE: NIA Academic Leadership Career Award

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The proposed research is relevant to public health as it will lead to better understanding of the etiology and drug resistance of Ras-driven cancers (a third of all cancers). By developing tools to profile, track, and perturb specific Ras isoforms in physiologically relevant cancer models, I propose to use these tools to understand how cancer cells re-organize Ras signaling during Ras inhibitor treatment to reactive oncogenic cellular programs. This work will provide critically needed tools and address how compartmentalized oncogenic signaling can dynamically adapt during drug treatment, thus is well-suited to meet the priorities outlined by NCI.

PI_NAMEs: ZHANG, JASON  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acceleration;addiction;Address;Advisory Committees;Affinity;Automobile Driving;Binding;Biology;bridge program;C-terminal;Cancer Biology;cancer cell;Cancer Model;Cell Culture Techniques;cell growth;Cell membrane;Cell model;Cells;Cellular biology;Chemicals;clinical efficacy;Communities;Compensation;Complex;Data;deep learning;design;Diagnostic;Directed Molecular Evolution;Disease;Drug resistance;Engineering;Environment;Enzymes;Etiology;experience;Fluorescence;Fluorescence Microscopy;Gene Silencing;Goals;Golgi Apparatus;improved;in silico;In Vitro;in vivo Model;inhibitor;interest;Learning;Lighting;Logic;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mentors;Methods;Microscopy;Molecular;Monitor;mutant;Mutate;new therapeutic target;novel;Oncogenic;Organoids;Outcome;Patients;Pharmacotherapy;Physiological;Play;programs;Protein Engineering;Protein Family;Protein Isoforms;Proteins;Proteomics;Public Health;RAS driven cancer;RAS inhibition;Ras Inhibitor;Relapse;Research;Resistance;resistance mechanism;Role;sensor;Signal Pathway;Signal Transduction;Structure;Techniques;Testing;Therapeutic;therapeutic target;tool;Training;tumor;tumor addiction;tumorigenesis;Work

PROJECT_TITLE: De novo designed Ras tools to uncover the mechanisms underlying drug resistance

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Washington

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: AMERICAN UNIVERSITY

ORG_STATE: DC

PHR: This is a multi-level mixed methods study to analyze the implications for racial health equity of policies that perpetuate structural racism in the domains of mass incarceration and housing and the potential for policy reforms in these domains to reduce race inequities in health. It will develop quantitative indices of structural racism in state policies in these domains, and measures of individuals’ exposures to these domains in the state of Connecticut (CT), and analyze their impacts on population and individual health outcomes, respectively. Through an in-depth qualitative analysis of the rollout of Clean Slate and Right to Council policies in CT, it will explore how policy reforms in these domains may represent interventions to promote racial health equity.

PI_NAMEs: BLANKENSHIP, KIM M. (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TITLE: Addressing the Impacts of Structural Racism on Race Inequities in Health: A Focus on Mass Incarceration, Housing, and their Intersection

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Complementary and Integrative Health;Dietary Supplements;Kidney Disease;Natural Products;Orphan Drug;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: The VHL tumor suppressor protein (pVHL) is often inactivated in clear cell Renal Cell Carcinoma (RCC), leading to continuous activation of the hypoxia-inducible-factor (HIF) pathway. Our proposed research aims to assess the potential of honokiol and its analogs, which act as HIF pathway inhibitors, as a promising therapeutic option for RCC treatment.

PI_NAMEs: MUKHERJI, MRIDUL  (contact)

PROJECT_TERMS: Address;analog;Angiogenesis Inhibitors;Angiogenic Factor;Animal Model;Belief;bevacizumab;Binding;Binding Sites;Blood Vessels;Boron;Cancer cell line;cancer type;Cell Line;Cell Proliferation;Cells;Cessation of life;chromatin immunoprecipitation;Clear cell carcinoma;Clear cell renal cell carcinoma;Clinical Trials;Cone;Crude Extracts;Cytotoxic Chemotherapy;Data;defined contribution;Dependence;Development;Disease;Distant;Down-Regulation;effective therapy;effectiveness evaluation;efficacy evaluation;Evaluation;Exhibits;expectation;experimental study;Foundations;Future;Gene Expression;Genes;Goals;hemangioblastoma;honokiol;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Hypoxia-Inducible Factor Pathway;Impairment;improved;In Vitro;inhibitor;kidney xenograft;Limited Stage;Magnolia;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Medical;Molecular;mouse model;Mus;Mutate;Nature;Neoplasms;neoplastic cell;neuroprotection;normoxia;novel;Operative Surgical Procedures;Oriental Medicine;Outcome;overexpression;Oxygen;Pathway interactions;PDGFB gene;Phytochemical;Platelet-Derived Growth Factor;Play;Property;prospective;Public Health;Regulation;Renal Cell Carcinoma;Research;Research Personnel;Resected;Resistance;Retina;Rights;Role;Safety;side effect;Signal Transduction;small molecule;stem;Structure;Structure-Activity Relationship;Systemic Therapy;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutically effective;tool;Toxic effect;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumorigenesis;Variant;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vegf Inhibitor;VHL mutation;Von Hippel-Lindau Tumor Suppressor Protein;Xenograft procedure

PROJECT_TITLE: Assessment of a recently developed boron-based HIF inhibitor as a prospective therapy for renal cell carcinoma (RCC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-B (M1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Regenerative Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Heart failure affects about 5.7 million adults in the United States and continues to be the leading cause of death globally, partly due to the limited therapeutic options. Direct cardiac reprogramming, which converts non- myocytes in the heart to induced cardiomyocytes, offers a promising alternative strategy for repairing the heart. This proposal will use state-of-art approaches to delineate the post-transcriptional mechanisms of this process for its future clinical implementation.

PI_NAMEs: XIE, YIFANG  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adult;Affect;Area;ATAC-seq;Award;Binding Proteins;Binding Sites;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;Cardiovascular Diseases;Cardiovascular system;career;Cause of Death;Cell Reprogramming;Cells;ChIP-seq;Chromatin;Cicatrix;clinical application;clinical implementation;clinical translation;clinically relevant;Cytoplasmic Granules;Data;Development;Disease Progression;DNA Binding;Environment;epigenetic regulation;Excision;Exhibits;Fibroblasts;Foundations;Future;GATA4 gene;Gene Expression;Generations;genome-wide;Goals;Heart;Heart failure;human disease;improved;in vivo;Induced Cardiomyocytes;Infarction;innovation;insight;interest;Learning;lipid nanoparticle;loss of function;Maintenance;Maps;Mediating;meetings;Mentors;Messenger RNA;Metabolism;Methylation;Modeling;Modification;Molecular;mRNA delivery;Mus;mutant;Myocardial dysfunction;Myocardial Infarction;Nature;novel therapeutics;overexpression;Patients;Play;Post-Transcriptional Regulation;posttranscriptional;Process;programs;Reader;regenerative;Regenerative capacity;Regulation;Regulator Genes;repair strategy;Research;Research Personnel;ribosome profiling;RNA Binding;RNA-Binding Proteins;Role;single-cell RNA sequencing;skills;Solid;Stem cell pluripotency;Techniques;Testing;Therapeutic;Time;Tissues;transcription factor;Transcription Process;Transcriptional Regulation;transcriptomic profiling;translational barrier;Translational Regulation;Translations;United States;Work

PROJECT_TITLE: Post-transcriptional mechanisms of direct cardiac reprogramming

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because it addresses a critical gap in survivor-centered approaches aimed at promoting GBV healing engagement while also exposing providers visually to many of the social determinants that influence the health and wellbeing of survivors' daily lives. This study's significance lies in its capacity to transform the landscape of GBV support services by shifting the focus from a deficit- oriented model to one centered on healing and active survivor participation in their recovery journey, particularly among sexual and gender minority (SGM) populations. Relevant to NINR's mission, this project aligns by targeting the prevention of disease and the promotion of wellbeing through its holistic approach, addressing health inequities among GBV survivors, and emphasizing health promotion within women and SGM communities.

PI_NAMEs: SINKO, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: SEAY, JULIA SUSAN

PROJECT_TERMS: acceptability and feasibility;Address;Automobile Driving;career development;Caring;Child Abuse;cis-female;cisgender;Collaborations;Communities;community collaboration;community engaged intervention;Decision Making;design;Development;Development Plans;Dimensions;Disability status;disorder prevention;Disparity;Disproportionately impacts women;Effectiveness;efficacy testing;empowerment;Ethnic Origin;Evaluation;Evidence based intervention;experience;Exposure to;Failure;Feasibility Studies;Feedback;follow-up;Fostering;Future;Gender;gender minority community;gender minority group;gender minority women;gender-based violence;Goals;healing;Health;health disparity;health equity;health equity promotion;health inequalities;Health Promotion;help-seeking behavior;Heterosexuals;holistic approach;implementation science;improved;Individual;Infrastructure;innovation;Intervention;intervention refinement;Interview;Interviewer;intimate partner violence;Lead;Life;Lived experience;marginalization;Mental Health;Methods;Mind;mindfulness;Mission;Modeling;Morbidity - disease rate;mortality;novel;Outcome;Outcomes Research;Participant;Patient Recruitments;Perception;Personal Satisfaction;Population;Positioning Attribute;preference;Problem Solving;Process;programs;prototype;Provider;psychologic;Public Health;Quality of life;Race;Randomized;Recommendation;Recovery;reduce symptoms;Research;Research Personnel;resilience;Resources;response;Sampling;Self Perception;service uptake;Services;Sex Orientation;Sexual and Gender Minorities;sexual assault;sexual minority group;sexual minority women;Sexuality;Shapes;skills;social;social determinants;social health determinants;structural determinants;Structure;substance use;Surveys;Survivors;survivorship;Testing;therapy design;therapy development;Time;Training;Transcend;transgender women;Trauma;trauma exposure;Treatment Efficacy;Victimization;Violence;Visual;Vulnerable Populations;Waiting Lists;Woman

PROJECT_TITLE: Photo-experiencing and Reflective Listening (PEARL) to Promote Healing Engagement for Women Survivors of Gender-based Violence: A Feasibility Study

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative This project aims to study the interaction between NaVs and ankyrin proteins. These proteins are critical neuronal proteins, dysfunction of which have been implicated in several neurodevelopmental and mental health disorders. Further understanding the interactions between these proteins on a molecular level is essential in the elucidation of the molecular and cellular mechanistic underpinnings of neurodevelopmental and mental health disorders and the future development of therapeutics.

PI_NAMEs: BENDER, KEVIN J;JENKINS, PAUL MICHAEL (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Affinity;Amino Acid Sequence;ANK2 gene;ANK3 gene;Ankyrin Repeat;Ankyrins;autism spectrum disorder;Axon;Binding;Binding Proteins;cohort;Cytoskeleton;Data;Dendrites;epileptic encephalopathies;Etiology;Family;Functional disorder;Future;Genes;genetic variant;Human;immunocytochemistry;link protein;Mediating;Membrane;Mental disorders;Molecular;Mutation;neocortical;Neurodevelopmental Disorder;neuronal excitability;Neurons;Patients;prevent;protein function;Proteins;Public Health;Pyramidal Cells;Scaffolding Protein;SCN2A protein;SCN8A gene;Site;Sodium Channel;Sodium Channel Binding;Techniques;therapeutic development;voltage

PROJECT_TITLE: Convergent mechanisms for neurodevelopmental disorder genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The placental vasculature is essential for the blood-placenta barrier, but the molecular mechanisms that regulate placental vascular growth and function remain poorly understood. The proposed research investigates how placental endothelial cells grow and function. The findings from this work will contribute to our understanding of the vascular component at the blood- placental barrier and offer new knowledge can be used to develop new treatment strategies for conditions associated with pregnancy-related cardiovascular complications.

PI_NAMEs: GAO, SIQI  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Affect;Amino Acids;angiogenesis;Bioinformatics;Biology;Blood;Blood Circulation;Blood Vessels;candidate validation;cardiovascular health;Cardiovascular Pathology;Cardiovascular system;career;career development;Cell Culture System;cell growth;Circulation;Complement;Confocal Microscopy;Data;Defect;Development;diagnostic biomarker;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Ensure;Environment;Epigenetic Process;Equilibrium;Etiology;Failure;fetal;Fetal Growth;Fetal Growth Retardation;Fetus;Foundations;Gases;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;Image;Imaging Techniques;In Vitro;in vivo;innovation;insight;Investigation;Knowledge;Label;Labyrinth;Learning;Light;Mammals;Maternal-Fetal Exchange;Mediator;Mentors;Metabolic;Metabolism;Molecular;Mothers;mouse genetics;Mus;mutant;novel therapeutic intervention;Nutrient;Organ;Oxygen;Pathologic;Pennsylvania;Phase;Placenta;Placental Biology;Play;Positioning Attribute;post-doctoral training;Pregnancy;programs;Protein Biosynthesis;protein transport;Proteomics;Regulation;Reporting;Research;research and development;Research Personnel;Role;Scanning Electron Microscopy;Signal Pathway;single cell genomics;single cell technology;single nucleus RNA-sequencing;skills;Specific qualifier value;Stains;Structure;System;Technical Expertise;Tissues;tool;Training;Transmission Electron Microscopy;Travel;treatment strategy;Universities;vascular bed;vascular factor;Waste Products;Western Blotting;Work;Yolk Sac

PROJECT_TITLE: Endothelial regulation of the blood-placental barrier


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Screening and Brief Intervention for Substance Misuse;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Hazardous alcohol use is highly prevalent among the millions of older adults who have chronic pain and contributes to greater pain severity, physical impairments, and the exacerbation of chronic pain over time. Although alcohol reduction/cessation can reduce pain and improve health, no interventions have been developed to identify and intervene upon hazardous drinking in older adults with chronic pain. The goal of this study is to develop, refine, and pilot test an alcohol screening, brief intervention, and referral to treatment protocol that meets the unique needs of older adults with chronic pain.

PI_NAMEs: LAROWE, LISA  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Affect;Aging;aging related;Alcohol abuse;Alcohol consumption;alcohol effect;alcohol intervention;alcohol screening and brief intervention;Alcohols;Award;Behavior Therapy;Benchmarking;brief intervention;career;chronic pain;chronic pain patient;Clinical;clinical care;Clinical Trials;cognitive function;Conduct Clinical Trials;coping;Data;Development;drinking;drinking behavior;Early Intervention;efficacy testing;Elderly;Environment;Focus Groups;follow-up;Funding;General Hospitals;Gerontology;Goals;hazardous drinking;Health;Health behavior change;improved;Institution;Intervention;intervention refinement;Interview;Massachusetts;Medical;medical schools;Mentors;Mentorship;Methods;Motivation;motivational enhancement therapy;multidisciplinary;multiple chronic conditions;older adult;Opioid Analgesics;Outcome;Pain;Pain management;pain reduction;Patients;Pattern;Physical Function;physical impairment;pilot test;pilot trial;Polypharmacy;post intervention;primary outcome;Procedures;Productivity;Protocols documentation;Psychologist;Qualitative Methods;Quality of life;Randomized;reduced alcohol use;Reporting;Research;Research Methodology;Risk;screening;screening, brief intervention, referral, and treatment;Self Efficacy;Severities;Structure;therapy development;Time;Training;Treatment Protocols;United States;United States National Institutes of Health;Work

PROJECT_TITLE: Development of a Tailored Alcohol Screening, Brief Intervention, and Referral to Treatment Protocol for Older Adults with Chronic Pain

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE We have generated a novel immunocytokine - anti-CD70-IL-21 fusion antibody for tumor-specific targeting of human IL-21, anti-CD70 mediated ADCC specifically within the RCC tumor microenvironment, and limiting side-effects arising from off-target effects of IL-21 seen with systemic administration. Our anti-CD70-IL-21 fusion antibody significantly enhances NK cells cytotoxicity against ccRCC. We expect that use of anti-CD70- IL-21 fusion antibodies will represent a novel treatment strategy and provide multiple benefits for patients with RCC.

PI_NAMEs: MAKHOV, PETR B. (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Affinity;Antibodies;antibody-dependent cell cytotoxicity;Antibody-drug conjugates;antitumor effect;Binding;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Death Induction;Cells;chimeric antigen receptor;Chronic;Clear Cell;Clinical;clinical efficacy;clinical implementation;Clinical Trials;clinically relevant;cytokine;cytotoxicity;Dendritic Cells;design;Development;Diagnosis;discontinuation trial;Disease;Dose;Dose Limiting;Drug Kinetics;Engineering;exhaust;experimental study;Family member;Future;Half-Life;Heparin Binding;Hepatotoxicity;high risk;Human;human model;humanized mouse;Immune;Immunity;immunodeficiency;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Inflammation;Interferon alpha;Interleukin-2;interleukin-21;interleukin-21 receptor;Interruption;Kidney;Ligands;Malignant Neoplasms;Mediating;mortality risk;Natural Killer Cells;next generation;novel;novel strategies;Operative Surgical Procedures;Outcome;Outcome Study;patient derived xenograft model;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Play;Property;Proteins;reconstitution;Recurrence;Recurrent tumor;Regimen;Regulatory T-Lymphocyte;Renal Carcinoma;Renal Cell Carcinoma;Reporting;response;Role;Sampling;side effect;Specificity;systemic toxicity;T cell response;T-Cell Proliferation;Testing;Therapeutic;therapeutic evaluation;Time;TNF gene;Toxic effect;treatment strategy;tumor;Tumor Antibodies;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Variant;Work

PROJECT_TITLE: A novel engineered IL-21-based immunocytokine as a therapeutic approach for tumor targeting in renal cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Immunotherapy;Lung;Lung Cancer;Women's Health Research

PHR: PROJECT NARRATIVE The emergence of immunotherapy has been practice-changing, however patients with EGFR-mutant non-small cell lung cancer (NSCLC) derive little benefit, as their tumors are typically resistant to checkpoint inhibitor drugs. Preliminary data from our group indicate for the first time that using an aromatase inhibitor (AI) to block the production of estrogen and its metabolites in mice with EGFR-mutant NSCLC can significantly increase immune cell infiltration into lung tumors and promote other anti-tumor effects. Suppressing estrogen species with an AI may be an effective strategy to enhance the efficacy of checkpoint inhibitors and improve long-term survival in patients with EGFR-mutant NSCLC.

PI_NAMEs: BODOR, JOSEPH NICHOLAS (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: antagonist;anti-PD1 therapy;antitumor effect;Archives;Aromatase;Aromatase Inhibitors;Attention;Attenuated;Biological Markers;biological specimen archives;Body Weight;bronchial epithelium;Cancer Etiology;Cancer Patient;cancer type;Carcinogens;Catechols;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cessation of life;checkpoint inhibition;Chromosome abnormality;Clinical;Clinical Trials;CYP1B1 gene;Cytokine Signaling;Data;design;Disease;Disease Progression;DNA strand break;Doxycycline;Drug Metabolic Detoxication;EGFR gene;Enzymes;Epidermal Growth Factor Receptor;Epithelial Cells;Estradiol;Estrogen Receptors;Estrogens;Estrone;Exhibits;Exons;experience;FOXP3 gene;Future;Gene Mutation;Genes;Goals;Granzyme;Growth and Development function;High Prevalence;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunologic Markers;immunosuppressed;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Incidence;Infiltration;inhibitor therapy;Interdisciplinary Study;Intervention Studies;Letrozole;Lung;Lung Adenocarcinoma;Lung Neoplasms;lung tumorigenesis;Lymphatic;Lymphocyte;Macrophage;male;Malignant Breast Neoplasm;Mammary Neoplasms;Metabolism;metaplastic cell transformation;Metastatic malignant neoplasm to brain;Molecular;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;neutrophil;never smoker;Non-Small-Cell Lung Carcinoma;novel;Parents;patient population;Patient Selection;Patients;PD-1 inhibitors;Perfusion;Phenotype;Play;Population;preclinical study;Production;programmed cell death ligand 1;prototype;Regimen;Regulatory T-Lymphocyte;Research;Resistance;response;Role;Smoke;Smoker;Structure of parenchyma of lung;T cell infiltration;Testing;therapy resistant;Time;time use;Toxic effect;Transforming Growth Factor beta;Translational Research;Translations;Treatment Protocols;tumor;Tumor Burden;tumor growth;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;Tumor-infiltrating immune cells;Tyrosine Kinase Inhibitor;women's diagnosis;young woman

PROJECT_TITLE: Estrogen Suppression as a Strategy to Enhance Immunotherapy Efficacy in EGFR-Mutated Non-Small Cell Lung Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (M2)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE This research contributes to the public health effort to improve alcohol use disorder treatment by providing the research community with novel human laboratory paradigms to screen promising medications for alcohol use disorder.

PI_NAMEs: MCKEE, SHERRY ANN (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: addiction;alcohol availability;alcohol craving;alcohol cue;Alcohol dependence;alcohol exposure;alcohol screening;alcohol use disorder;Alcohols;analog;Behavior;Beverages;binge drinking;Cigarette;Clinical;clinical efficacy;Clinical Trials;Communities;Consumption;cost effective;Data;deprivation;design;Development;Dose;drinking;drinking behavior;Drug Industry;Evaluation;Exposure to;Heavy Drinking;Human;Impairment;improved;Investigation;Laboratories;Maps;model design;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nicotine;novel;Outcome;Participant;patient engagement;Pharmaceutical Preparations;Phase;predictive modeling;Procedures;Process;Psychological reinforcement;Public Health;Randomized;Relapse;Research;Resources;Risk;screening;Self Administration;Severities;Signal Transduction;Smoke;Smoker;Smoking;smoking cessation;smoking cue;smoking relapse;Stress;Tobacco;Treatment outcome;Work;World Health Organization

PROJECT_TITLE: Developing a novel human laboratory paradigm for AUD medication screening:  Modeling the ability to resist drinking and heavy drinking

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Ductal carcinoma in situ (DCIS) is a benign breast disease reported by 25% of all breast screens in the US and has the potential to become invasive breast cancer. There are currently no tools that can predict which DCIS lesions will become invasive breast cancer, leading to significant overtreatment. This proposal investigates how changes in protein expression around DCIS lesion can be used to predict which lesions will become invasive breast cancer.

PI_NAMEs: ANGEL, PEGGI M (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Age;alpha 2 collagen type I;Amino Acids;Architecture;Area;Atlases;Benign;Binding;biomarker evaluation;biomarker signature;biosignature;black women;Body mass index;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;Breast conservation;Breast Diseases;breast lumpectomy;cancer diagnosis;Cancer Patient;Cancer Prognosis;capsule;Cell Proliferation;Cells;cellular targeting;Cessation of life;Characteristics;Clinical;clinical diagnosis;Collagen;Collagen Fiber;Comedo;Complex;Contralateral;Correlation Studies;Coupled;Data;Detection;Diagnosis;disparity reduction;Ethnic Population;Evaluation;follow-up;Goals;Growth;hazard;head involution defective protein;Heterogeneity;high risk;Histology;Hydroxylation;Immunohistochemistry;improved;In Situ Lesion;insight;Invaded;Knowledge;Lead;Length;Lesion;Link;Literature;Location;Machine Learning;machine learning algorithm;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;mass spectrometric imaging;Mastectomy;Measures;Molecular;molecular marker;Monitor;multimodality;Necrosis;Noninfiltrating Intraductal Carcinoma;novel marker;Nuclear Grade;Outcome;outcome prediction;overtreatment;Pathologic;Pathology;pathology imaging;Pathway interactions;Patient risk;patient stratification;Patients;Pattern;Peptide Hydrolases;Peptides;Play;Post-Translational Protein Processing;Predictive Value;Probability;Process;progression risk;Proline;prospective;protein expression;Proteome;proteomic signature;Proteomics;Race;racial diversity;racial population;Radiation;Recurrence;Regulation;Reporting;Resources;Risk;Risk Marker;Role;Scanning;Sensitivity and Specificity;Signal Transduction;Site;Solid;Structure;Systems Biology;Tertiary Protein Structure;Testing;Time;Tissue Microarray;Tissues;tool;treatment disparity;tumor;Variant;White Women;Width;Woman;Work

PROJECT_TITLE: Spatial stromal proteomic biosignatures of DCIS risk and progression


NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Heart Disease;Heart Disease - Coronary Heart Disease;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Women have a 20% higher risk experiencing heart failure or mortality within five years following their first acute myocardial infarction compared to men. This proposal aims to address this disparity by determining the role of thyroid hormones, an underexplored sexually dimorphic risk factor for heart failure development in females. Specifically, we will focus on the tissue-level regulatory mechanisms of thyroid hormones that may contribute to sex differences in the development of heart failure, potentially paving the way for the development of new therapeutic approaches.

PI_NAMEs: DA SILVA TEIXEIRA, SILVANIA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acute myocardial infarction;Address;Adult;Animals;Area;Automobile Driving;Biology;Brain;Cardiac;Cardiac health;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;Cardiovascular system;Cause of Death;Data;Deferoxamine;Development;Disparity;disparity reduction;EFRAC;Enzymes;Estrogen Replacement Therapy;Estrogens;Exhibits;experience;Face;Female;Functional disorder;Heart;Heart Diseases;Heart failure;heart function;High Prevalence;high risk;hormone metabolism;hormone regulation;Human;Impairment;improved;Iodide Peroxidase;Knock-out;Knowledge;Laboratories;Lead;male;Measures;Mediating;men;Menopause;Metabolic syndrome;Mitochondria;Molecular;mortality;Mus;Myocardial;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel therapeutic intervention;operation;Operative Surgical Procedures;Outcome;Ovariectomy;Pharmaceutical Preparations;Physiological;Play;Postmenopause;Predisposition;Premenopause;programs;protective effect;Proteomics;Recovery;Regulation;reproductive hormone;Research;Respiration;response;Risk;Risk Factors;Role;Science;sex;Sex Differences;sexual dimorphism;Smoking;Testing;Thyroid Diseases;Thyroid Gland;Thyroid Hormones;Tissue Banks;Tissues;Training;transcriptomics;Wild Type Mouse;Woman;Women's Health;women's outcomes;Work;working group

PROJECT_TITLE: Unraveling tissue level regulation of thyroid hormone and its role in sex differences in cardiovascular health

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-A (M1)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Cytolethal distending toxin (CDT), which is produced by several pathogens, has three subunits: two cell- binding proteins and a third catalytic protein. In order to function, the catalytic subunit must dissociate from the cell-binding subunits. Understanding the molecular details of this process could assist the design of therapeutic strategies that prevent the disassembly and activity of CDT.

PI_NAMEs: TETER, KENNETH R (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Active Sites;Affect;ATP phosphohydrolase;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Catalytic Domain;Cell membrane;Cell Nucleus;Cell surface;Cells;Cellular biology;Collaborations;Complex;cytolethal distending toxin;Deoxyribonucleases;design;dimer;Dissociation;DNA;DNA Damage;Endocytosis;Endoplasmic Reticulum;Endosomes;Event;experimental study;Foundations;Generations;Genomic Instability;Goals;Golgi Apparatus;Hemophilus ducreyi;holotoxins;In Vitro;inhibitor;insight;Intoxication;Intracellular Transport;Link;Malignant Neoplasms;Membrane;Methods;Microbiology;Modeling;Molecular;Mutagens;NMR Spectroscopy;Nuclear Translocation;pathogen;Phosphoric Monoester Hydrolases;Physiology;Pilot Projects;Play;prevent;Process;Proteins;protonation;rational design;Recombinants;Reporting;Resistance;Rest;Roentgen Rays;Role;Route;Series;Site;structural biology;Structure;System;Testing;Therapeutic;Toxin;tumorigenesis;Variant;Vesicle;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular Basis for the Two-Stage Disassembly of Cytolethal Distending Toxin

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE This proposal aims to study dietary saturated fats' effects on platelet reactivity in obesity, focusing on their incorporation into platelet membranes, associated changes in platelet reactivity, and effects on platelet lipid rafts and subsequent signaling. These results may inform interventions for obesity-related cardiovascular issues.

PI_NAMEs: BARRACHINA, MARIA N. (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Antiplatelet Drugs;Atherosclerosis;Automobile Driving;Biology;Blood Platelets;cardiovascular disorder risk;Cardiovascular system;Cell membrane;Cells;Chemistry;cost;Data;density;Deposition;Diet;Diet Modification;dietary;Dietary Factors;Dietary Fats;Disease;Doctor of Philosophy;Dose;Event;Exhibits;experimental study;Fatty Acids;Future;Health;Heart failure;High Fat Diet;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Intervention;Investigation;Knowledge;Link;lipidome;Lipids;Medical Care Costs;Megakaryocytes;Membrane;Membrane Lipids;Membrane Microdomains;Mus;novel;Obese Mice;obese patients;obese person;Obesity;obesity management;obesity treatment;Outcome;Pathogenesis;pharmacologic;Pharmacology Study;Plasma;Platelet Activation;platelet function;platelet phenotype;Play;Population;receptor;Receptor Signaling;Research;risk mitigation;Role;saturated fat;Saturated Fatty Acids;Signal Transduction;Sphingomyelins;Testing;Thrombosis;thrombotic;Thrombus;Translating;United States;uptake

PROJECT_TITLE: Unraveling Fatty Acid-driven Mechanisms of Platelet Hyper-Activation in Obesity


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project narrative:  High-resolution structural information is essential for understanding the molecular basis of a number of diseases. Among the important requirements for obtaining such information are (1) the routinely available capability to study the conformation and oligomeric states of biomedically relevant proteins and protein complexes both in crystals and in solution, including methods for handling the poorly-diffracting crystals often generated by membrane-receptors, ion channels, and signaling proteins, and (2) the means to continue to improve on the available techniques, extending our knowledge of complex systems which are currently poorly understood. MacCHESS will provide the necessary facilities and access to technology to help to generate structure- function information of great interest to the biological and biomedical communities.

PI_NAMEs: CERIONE, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Automobile Driving;Bacterial Infections;beamline;Behavior;Binding;Biological;Biological Process;Biology;Biomedical Research;clinical development;Communities;Complex;Computer software;conformational conversion;Continuing Education;Crystallography;Data;Dedications;design;Development;Diffuse;Disease;DNA;Drug Targeting;Education and Outreach;Educational workshop;Emerging Technologies;empowerment;Ensure;enzyme activity;Enzymes;Equipment;experience;experimental study;flexibility;Fostering;Funding;Genetic Transcription;Goals;Government;improved;Infrastructure;insight;Institution;instrumentation;interest;Ion Channel;Knowledge;Leadership;Ligands;Macromolecular Complexes;macromolecule;Malignant Neoplasms;Membrane;Metabolism;method development;Methodology;Methods;Mission;Molecular;Molecular Conformation;Motion;Neurodegenerative Disorders;new technology;new therapeutic target;Nucleic Acids;operation;Outcome;Pharmaceutical Preparations;Play;Postdoctoral Fellow;pressure;protein complex;Proteins;receptor;repaired;Reporting;Research Personnel;Resolution;Resources;RNA;RNA Splicing;Roentgen Rays;Role;Schedule;Science;Scientist;Shapes;Signal Transduction;Signaling Protein;Source;Strategic Planning;Structural Biologist;structural biology;Structure;Students;Synchrotrons;System;Techniques;Technology;Temperature;Time;Training;United States National Institutes of Health;Virus Diseases;working group

PROJECT_TITLE: MacCHESS Synchrotron Source for Structural Biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-L (45)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PROJECT_TERMS: Address;Advisory Committees;Annual Reports;Bacterial Infections;beamline;Binding;Biological;Biological Process;Biology;Biomedical Research;clinical development;Coffee;Collaborations;Collection;Communication;Communities;Complex;Computer software;conformational conversion;Crystallography;Data;Data Analyses;Data Collection;Dedications;Deposition;design;Development;Diffuse;Disease;DNA;Drug Targeting;Education and Outreach;Educational workshop;Effectiveness;Emerging Technologies;Ensure;enzyme activity;Enzymes;Equipment;Essential worker;Evaluation;Event;Expenditure;experience;Feedback;flexibility;Fostering;Funding;Genetic Transcription;Goals;Government;Health;Hour;Human;Human Resources;improved;insight;Institution;interest;Internet;Ion Channel;Knowledge;Lead;Leadership;Ligands;Macromolecular Complexes;Malignant Neoplasms;meetings;member;Membrane;Metabolism;method development;Methods;Molecular;Molecular Conformation;Motion;Neurodegenerative Disorders;new therapeutic target;Nucleic Acids;operation;Organizational Efficiency;organizational structure;outreach;Performance;Persons;Pharmaceutical Preparations;pressure;prevent;Procedures;Process;Productivity;programs;protein complex;Proteins;Publications;receptor;Refuse Disposal;repaired;Report (document);Reporting;Research Personnel;Resolution;Resource Allocation;Resources;RNA;RNA Splicing;Roentgen Rays;Role;Running;Safety;Schedule;Services;Shapes;sharing platform;Signal Transduction;Signaling Protein;social media;Source;Strategic Planning;structural biology;Structure;Synchrotrons;System;Techniques;Technology;Temperature;Time;Training;United States National Institutes of Health;Update;Virus Diseases;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MEISBURGER, STEPHEN PAUL (contact)

PROJECT_TERMS: Adopted;Automatic Data Processing;Automation;Bacterial Infections;beamline;Binding;Biological;Biological Process;Biology;Biomedical Research;Cells;clinical development;Communities;Complex;Computer software;conditioning;conformational conversion;Controlled Environment;Crystallography;Custom;Data;Data Collection;data collection site;data management;design;Development;Diagnostic Equipment;Diamond;Diffuse;Disease;DNA;Drug Targeting;Education and Outreach;Electronics;Emerging Technologies;Engineering;Environment;enzyme activity;Enzymes;Equipment;experimental study;flexibility;Funding;Genetic Transcription;Government;High Performance Computing;Humidity;Hybrids;improved;Infrastructure;insight;Institution;instrumentation;interest;Ion Channel;Knowledge;Laboratories;Ligands;Light;Macromolecular Complexes;Malignant Neoplasms;Measurement;Membrane;Metabolism;method development;Methods;Microscope;Molecular;Molecular Conformation;Motion;Neurodegenerative Disorders;new therapeutic target;novel strategies;Nucleic Acids;open source;operation;Optics;peer;Performance;Pharmaceutical Preparations;photon-counting detector;Positioning Attribute;pressure;programs;protein complex;Proteins;prototype;Pythons;receptor;repaired;Research;Research Personnel;Resolution;Resources;RNA;RNA Splicing;Robotics;Roentgen Rays;sample collection;Sampling;Shapes;Signal Transduction;Signaling Protein;Site;Source;Speed;structural biology;Structure;Synchrotrons;System;Techniques;Technology;Temperature;Time;tool;Training;United States National Institutes of Health;Virus Diseases;X ray diffraction analysis

PROJECT_TITLE: FlexX


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: GILLILAN, RICHARD EDWARD (contact)

PROJECT_TERMS: Address;Area;Automobile Driving;Bacterial Infections;base;beamline;Behavior;Binding;Biological;Biological Process;Biology;Biomedical Research;Biophysics;Calibration;clinical development;Communities;Complex;Computer software;computerized data processing;conformational conversion;Consumption;Coupled;Crystallography;Custom;data collection site;data reduction;Dependovirus;design;detection sensitivity;Development;Diffuse;Disease;DNA;Drug Targeting;Education and Outreach;Educational workshop;Emerging Technologies;Ensure;enzyme activity;Enzymes;Equipment;experience;flexibility;Funding;Genetic Transcription;Goals;Government;Growth;Home;Hour;improved;insight;Institution;instrumentation;interest;Ion Channel;Knowledge;Learning;lectures;Ligands;lipid nanoparticle;Liquid substance;Macromolecular Complexes;magnetic field;Malignant Neoplasms;Membrane;Metabolism;metalloenzyme;method development;Methodology;Methods;Modeling;Molecular;Molecular Conformation;Molecular Sieve Chromatography;Monoclonal Antibodies;Monoclonal Antibody Therapy;Motion;Nature;Neurodegenerative Disorders;new therapeutic target;Nucleic Acids;operation;outreach;Oxygen;Peer Review;Pharmaceutical Preparations;Phase;Physiological;Play;Preparation;pressure;Process;Productivity;program dissemination;programs;Property;protein complex;Proteins;Publications;Quality Control;receptor;repaired;Research;Research Personnel;Resolution;RNA;RNA Splicing;Roentgen Rays;Role;Sampling;Services;Shapes;Signal Transduction;Signaling Protein;Site;Source;Speed;structural biology;Structure;Students;success;symposium;Synchrotrons;System;Techniques;Technology;Temperature;Therapeutic;Time;Training;United States National Institutes of Health;user-friendly;Virus Diseases;Visit;Work

PROJECT_TITLE: BioSAXS


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases

PI_NAMEs: WIERMAN, JENNIFER  (contact)

PROJECT_TERMS: Bacterial Infections;beamline;Binding;Biological;Biological Process;Biology;Biomedical Research;clinical development;Collaborations;Communities;Complex;Computer software;computerized data processing;conformational conversion;Crystallography;Data;Data Analyses;Data Collection;data quality;data reduction;design;Development;Diffuse;Disease;DNA;Documentation;Drug Targeting;Education and Outreach;Educational process of instructing;Educational Status;Educational workshop;Emerging Technologies;Ensure;Environment;enzyme activity;Enzymes;Equipment;experimental study;Feasibility Studies;Fertilization;flexibility;follow-up;Funding;Genetic Transcription;Goals;Government;Home;improved;insight;Institution;instrument;instrumentation;interest;International;Ion Channel;Knowledge;Leadership;Learning;lectures;Ligands;Macromolecular Complexes;Malignant Neoplasms;meetings;Membrane;Metabolism;method development;Methods;Molecular;Molecular Conformation;Motion;Neurodegenerative Disorders;new technology;new therapeutic target;Nucleic Acids;open data;operation;outreach program;Pharmaceutical Preparations;Postdoctoral Fellow;Preparation;pressure;Procedures;Professional Organizations;professor;protein complex;Proteins;Protocols documentation;Publications;Publishing;receptor;repaired;Research;Research Personnel;Resolution;RNA;RNA Splicing;Roentgen Rays;Safety;Sampling;Science;Scientist;Shapes;Signal Transduction;Signaling Protein;Site;Source;structural biology;Structure;Students;success;Synchrotrons;System;Techniques;Technology;Temperature;Time;tool;Training;Translating;United States National Institutes of Health;Universities;Virus Diseases;Visit

PROJECT_TITLE: Training and Outreach


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Prevention;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE To address high unmet need for postpartum family planning (PPFP) in Zambia, we will undertake the necessary formative work to develop and pilot test an innovative, evidence-based intervention to improve PPFP services. This intervention could dramatically improve birth spacing, reduce abortion, and reduce maternal-child morbidity and mortality in Zambia. Moreover, our PPFP intervention is a potentially replicable and sustainable model that could be expanded to countries across the region.

PI_NAMEs: INAMBAO, MUBIANA ;WALL, KRISTIN MARIE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: abortion;Achievement;Address;African;antenatal care;Area;Birth Intervals;Cessation of life;Child;Cities;Client;Client satisfaction;Cluster randomized trial;community building;Contraceptive methods;cost;cost effectiveness;Counseling;Country;Couples;Decision Making;Developing Countries;Evidence based intervention;Family health status;Family Planning;Family Planning Center;Family Planning Training;Fertility;Focus Groups;Funding;Goals;Government;Health;Health Personnel;Health Priorities;Hospitals;Implant;implementation determinants;implementation measures;implementation strategy;improved;Individual;Infant;innovation;Institution;Insurance;interest;Intervention;Interview;Intrauterine Devices;Knowledge;low and middle-income countries;maternal morbidity;Maternal Mortality;member;Men's Role;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;neonatal morbidity;Nurses;Office Nursing;organizational readiness;patient oriented;pilot test;Policies;post intervention;post pregnancy;Postpartum Period;Postpartum Women;preference;Pregnancy;pregnant;Pregnant Women;Prenatal care;prepregnancy;prevent;Prevention;Procedures;Provider;Recommendation;recruit;Regulation;Reproductive Health Services;Research;Research Personnel;Resource Allocation;reversible contraceptive;rural health clinic;Rwanda;scale up;service delivery;Services;side effect;Teaching Hospitals;Testing;theories;tool;Training;Universities;uptake;Vaccination;Woman;Women's Health;Work;World Health Organization;Zambia

PROJECT_TITLE: Promoting healthy interbirth intervals through post-partum reproductive health services

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Narrative We predict that arming T cells with protected EZH2 function will greatly improve the ability of a T cell to persist in melanoma and other solid tumors. Cancer cells leverage EZH2 for this very purpose and it is likely T cells will benefit similarly. Results from these studies could increase efficacy and durability of adoptive therapy and combinatorial strategies to treat patients with metastatic melanoma and other solid cancers.

PI_NAMEs: KOSS, BRIAN ;TACKETT, ALAN  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Amino Acids;Antigen Presentation;arm;cancer cell;CAR T cell therapy;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Survival;chimeric antigen receptor T cells;Clinical;combinatorial;Combined Modality Therapy;Complex;Cytotoxic T-Lymphocytes;Data;Development;Disease Progression;Drug resistance;Effectiveness;Engineering;Environment;epigenome;epigenomics;Event;exhaust;exhaustion;experience;experimental study;EZH2 gene;gene induction/repression;Genetic Transcription;Histone H3;histone methyltransferase;I-antigen;immune checkpoint blockade;Impairment;improved;In Vitro;in vivo;Infiltration;inhibitor;innovation;Invaded;Lysine;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Melanoma Tumor;Metabolic;Metastatic Melanoma;Methylation;Methyltransferase;mutant;Mutation;Outcome;Patients;Phenotype;Phosphorylation;Play;Polycomb;preservation;prevent;Proliferating;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regulatory T-Lymphocyte;Reporting;Resistance;resistance mechanism;Resources;Role;Series;small molecule;Solid;Solid Neoplasm;Stress;success;T cell therapy;T-Cell Activation;T-Lymphocyte;targeted treatment;Techniques;Testing;transcriptional reprogramming;transcriptomics;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Leveraging cancer-evolved resistance mechanisms to enhance EZH2 activity in adoptive T cells


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition

PHR: PROJECT NARRATIVE The parabrachial nucleus serves as a crucial sensory hub, relaying data from internal and external senses to shape motivated behaviors; in this intricate network, the activation of melanocortin 3 and 4 receptors (MC3R and MC4R) expressing neurons can either stimulate or suppress ingestive behaviors. Of particular importance, the PBN MC3R neurons represent a novel population in the PBN as they contradict the overall role of the PBN in inhibiting feeding. Understanding how these two neuronal populations in the PBN integrate opposing ingestive behaviors is the major goal of this project.

PI_NAMEs: DAHIR, NAIMA  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Abnormal coordination;Acute;Adaptive Behaviors;Agonist;Anatomy;Anxiety;Appetite Regulation;Appetitive Behavior;Behavior;Brain;Brain region;Cell Nucleus;Cells;Chronic;Complex;Cone;Consummatory Behavior;Consumption;Critical Thinking;Cues;Data;Desire for food;drinking;drinking behavior;Eating;Electrophysiology (science);Ensure;experimental study;feeding;Feeding behaviors;Fiber;Food;food consumption;Genetic;Goals;Hyperphagia;Hypothalamic structure;Immunohistochemistry;Impairment;Ingestion;Knock-out;Lateral;Lead;Ligands;Light;Liquid substance;Long-Term Effects;Longitudinal Studies;loss of function;LoxP-flanked allele;Maps;Measures;Medial;Mediating;melanocortin receptor;Mentors;Metabolic;Microscopy;Monitor;motivated behavior;Mus;neural;neural circuit;Neuroanatomy;neuron loss;Neurons;Neuropeptides;novel;Nutritional;optogenetics;Organism;Outcome;Output;parabrachial nucleus;Peripheral;pharmacologic;Pharmacology;Phenotype;photoactivation;Photometry;Play;Population;postsynaptic neurons;preference;Process;programs;Prosencephalon;Proteins;receptor;Regulation;Research;response;Role;Satiation;Sensory;sensory input;Sensory Process;Shapes;Signal Transduction;Slice;Stimulus;Structure of nucleus infundibularis hypothalami;Synapses;Synaptic Potentials;System;Taste Perception;Testing;Therapeutic;Time;Training;Viral;Virus

PROJECT_TITLE: The Role of the PBN Melanocortin System in the Regulation of Ingestive Behaviors

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: DURHAM

ORG_DEPT: GENETICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Zika virus is a mosquito-borne RNA virus that has become a serious global concern due to its ability to cause neurological birth defects. This proposal is an integrated effort that combines identifying natural human genetic differences regulating Zika virus cellular entry, replication, and host gene expression with rigorous experimental validation studies. Successfully carrying out this work will identify specific genetic differences that regulate Zika virus infection and may also reveal new targets for host-directed therapies.

PI_NAMEs: KO, DENNIS CHUN-YONE (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;African;African ancestry;Age;Alleles;American;Americas;Asian;B lymphocyte immortalization;B-Lymphocytes;Brain;Brazil;Catalogs;causal variant;CCR5 gene;cell type;Cells;Clinical;clinically relevant;Complex;Congenital Abnormality;congenital zika syndrome;Coupling;CRISPR/Cas technology;Data;Detection;diagnostic strategy;Disease Resistance;Dizygotic Twins;Drug Targeting;Environment;Epidemic;Exhibits;experimental study;Female;Fetus;Future;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Transcription;genetic variant;Genetic Variation;Genome;genome wide association study;genomic locus;Genotype;Goals;Heritability;HIV;Human;Human Genetics;Immune;In Vitro;Individual;Infection;infection rate;inhibitor;insight;inter-individual variation;lymphoblastoid cell line;Macaca mulatta;Malaria;Measurement;Measures;Mediating;Microcephaly;mosquito-borne;nerve stem cell;Neurologic;novel;novel diagnostics;novel therapeutic intervention;offspring;Outcome;Parents;Pathogenesis;Pathway interactions;Penetrance;Peripheral Blood Mononuclear Cell;personalized care;Phenotype;Population;Predisposition;Publishing;Quantitative Trait Loci;Resistance;Resolution;response;Risk;RNA Viruses;Severities;Sickle Cell;single-cell RNA sequencing;Site;Testing;transcriptomics;treatment strategy;trophoblast;Twin Multiple Birth;Validation;validation studies;Variant;Viral;Virulence;virus genetics;Work;ZIKA;Zika Virus;ZIKV infection

PROJECT_TITLE: Human Genetic Variation Regulating Cellular Susceptibility to Zika Virus

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative The airway mucosa is the initial site of interaction with Mycobacterium tuberculosis. While the mucosa itself forms a critical barrier to infection, it is also the anatomic location where cells of the mucosal, innate and adaptive immune systems converge to orchestrate protective immediate and long-term responses. We have demonstrated that M. tuberculosis can migrate and enter the mucosa associated lymphoid tissue via a rare, specialized cell type called a microfold cell. Here we propose to better characterize features of the airway M cell, establish how it communicates with other epithelial and immune cells, determine the mechanism by which the bacteria traverse the cell and the immunologic consequences of early microfold cell contact with M. tuberculosis. This approach is novel because it represents the first broad characterization of the role of airway microfold cells to host defense against M. tuberculosis.

PI_NAMEs: SHILOH, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: Accounting;adaptive immune response;Adaptive Immune System;adaptive immunity;Adenoidal structure;Aerosols;Alleles;Amino Acids;Anatomy;Animals;Antigen Presentation;Antigens;Applied Genetics;Atlases;B-Lymphocytes;Bacteria;Binding;Biochemical;Bioinformatics;CD4 Positive T Lymphocytes;Cell Communication;Cell Culture Techniques;Cell Physiology;cell type;Cells;Cellular biology;Cervical Tuberculous Lymphadenitis;Chemicals;Communication;Data;Dedications;Dendritic Cells;Epithelial Cells;Epithelium;Event;Gene Expression Profile;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;glycosylation;Goblet Cells;Homeostasis;Host Defense;Human;Human body;human morbidity;human mortality;Immune;immune function;Immune response;Immunity;Immunologics;Immunology;improved;In Vitro;in vivo;in vivo Model;Infection;Ingestion;Inhalation;innate immune function;Innate Immune Response;Innate Immune System;innovation;intercellular communication;Life Cycle Stages;Ligands;Location;Lymphoid Tissue;M cell;Macrophage;Mediastinal;Mediating;microbicide;migration;Modeling;Molecular;mortality;mucosa-associated lymphoid tissue;Mucosal Immune System;Mucosal Immunity;Mucous Membrane;Mus;mutant;Mycobacterium tuberculosis;Nasopharynx;Natural Immunity;Nose;novel;novel strategies;Oral;Oral mucous membrane structure;Organism;Oropharyngeal;Outcome;pathogen;Penetration;Process;programs;receptor;Receptor Cell;Research;Respiratory Mucosa;Respiratory Tract Infections;response;Role;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;Specialized Epithelial Cell;SR-BI receptor;Structure;Structure-Activity Relationship;Surface;Systemic disease;T cell response;T-Lymphocyte;Testing;transcriptome;transcriptomics;transcytosis;Tuberculosis;tuberculosis immunity;Virulence Factors;Work

PROJECT_TITLE: Interaction of Mycobacterium tuberculosis with upper airway mucosal cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (M1)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narratives/Relevance  We hypothesize that in Alzheimer's disease (AD), PET imaging of Braak I- II brain regions using [18F]MK6240 tau radiotracer and Prism-PET/EMMT scanner may be the earliest biomarker for detecting tau aggregation and AD severity in asymptomatic individuals.

PI_NAMEs: CHIANG, GLORIA CHIA-YI;GOLDAN, AMIRHOSSEIN  (contact);QI, JINYI

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Amyloid;Amyloid beta-Protein;attenuation;Back Pain;Binding;Biological Markers;Brain;brain health;Brain region;Cations;Claustrophobias;clinical translation;Cognitive;Communities;Compensation;Computed Tomography Scanners;cost;cost effective;cranium;Data;data exchange;deep learning;Deposition;Development;Dose;Dura Mater;Early Diagnosis;Electromagnetics;entorhinal cortex;Evaluation;Female;first-in-human;Head;Health system;high resolution imaging;Hippocampus;Human;Image;image reconstruction;Imaging Phantoms;improved;in vivo;Individual;Joint repair;man;Maps;Measurement;Meningeal;metropolitan;mild cognitive impairment;Morphologic artifacts;Motion;neuroimaging;Pattern;Performance;Physics;portability;Positioning Attribute;Positron-Emission Tomography;quasar;radiotracer;reconstruction;recruit;Resolution;ROC Curve;Scanning;Severity of illness;Signal Transduction;Supination;System;Systems Integration;tau aggregation;tau Proteins;Thinness;Time;Tracer;ultra high resolution;Validation;Vision;X-Ray Computed Tomography

PROJECT_TITLE: Prism-PET/EMMT: High resolution, cost effective, portable, and upright brain PET scanner for early diagnosis of Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: BOSTON

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D), which is characterized by the loss of insulin-producing beta cells, is a chronic condition that carries significant global morbidity and mortality. While multiple genetic risk factors have been implicated in T1D pathophysiology, T1D genetic risk among non-European populations is less well understood. In this proposal, we will assemble genomic data from diverse ancestral populations to improve prediction of T1D risk, to identify genetic subtypes of T1D, and to refine classification of atypical immune-mediated forms of diabetes.

PI_NAMEs: DEUTSCH, AARON JONATHAN (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Acute;Adopted;Adult;Affect;African;Autoimmune;Autoimmune Diabetes;autoimmune pathogenesis;Beta Cell;Cardiovascular Diseases;career;Caring;causal variant;Child;Chronic;Classification;Clinical;Complications of Diabetes Mellitus;Computational Biology;Computing Methodologies;computing resources;Data Set;Diabetes Mellitus;diabetes mellitus genetics;diabetes risk;Diabetic Ketoacidosis;Diagnosis;Disease;disorder risk;diverse data;Environment;European;experience;Foundations;Functional disorder;Funding;Gene Frequency;General Hospitals;Genetic;genetic analysis;genetic architecture;Genetic Determinism;genetic information;Genetic Research;Genetic Risk;genetic risk factor;genetic variant;Genome;genome wide association study;genomic data;Genotype;health care disparity;high risk;HLA Antigens;Human Genetics;Immune;Immune checkpoint inhibitor;immune function;improved;Individual;innovation;Insulin;Insulin deficiency;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Kidney Diseases;Life Expectancy;Massachusetts;Mediating;Methods;Modeling;Monoclonal Antibody Therapy;Morbidity - disease rate;mortality;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;phenotypic data;Physicians;Population;Population Heterogeneity;prevent;Research;Research Personnel;Retinal Diseases;Risk Factors;risk prediction;risk variant;Scientist;skills;tool;Training;trait;Variant;Work

PROJECT_TITLE: Multi-Ancestry Genetic Analysis of Type 1 Diabetes and Related Conditions

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Muscular Dystrophy;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Physical Activity;Prevention;Rare Diseases

ORG_DEPT: SURGERY

PHR: This proposal is focused on translational and clinical research in gene therapy to safely address an ultra-rare subset of Duchenne muscular dystrophy (DMD) patients excluded from ongoing dystrophin-based gene therapy trials. The rationale is the avoidance of destructive T cell responses to dystrophin epitopes by substituting the non-immunogenic dystrophin-related protein utrophin, composed entirely of “self” peptide epitopes to take advantage of central immunological tolerance. The project makes appropriate use of preclinical models to address major limitations identified in ongoing clinical studies, focusing on IND-enabling experiments that pertain to both FDA regulations and to the anticipated risks and potential benefits to DMD patients.

PI_NAMEs: STEDMAN, HANSELL H (contact)

PROGRAM_OFFICER_NAME: BOSHOFF, CHRIS

PROJECT_TERMS: absorption;Accelerometer;Activities of Daily Living;Address;adeno-associated viral vector;Age;Alternative Therapies;Animal Model;Animals;Becker Muscular Dystrophy;Biochemical;Biodistribution;Biological Assay;Biological Markers;biomarker performance;Blinded;canine model;Cessation of life;Childhood;Clinical;clinical investigation;Clinical Research;Clinical Trials;Collaborations;Complex;connectin;Cyclic GMP;Cytoskeletal Proteins;Data;Dependovirus;design;Development;Diagnosis;Disease;Dose;Duchenne muscular dystrophy;Dystrophin;early childhood;efficacy evaluation;efficacy study;Enrollment;Ensure;Enzyme-Linked Immunosorbent Assay;Epitopes;Exclusion;Exons;experimental study;FDA approved;Feedback;Functional disorder;Gene Mutation;gene therapy;gene therapy clinical study;Gene therapy trial;Gene Transduction Agent;Genes;Genetic;Genetic Diseases;Genetic Risk;German population;Glycoproteins;Hair;Human;Immune Evasion;Immune Tolerance;immunogenic;in vivo;Incidence;Injury;innovation;Institutional Review Boards;Length;Link;male;manufacture;mdx mouse;Measurable;Measurement;Mediating;Medicine;Membrane;micro-dystrophin;miniaturize;Mission;multidisciplinary;Muscle;Muscle Cells;Muscle Contraction;Muscular Dystrophies;Mutation;Myopathy;N-terminal;National Institute of Neurological Disorders and Stroke;Nature;Neuromuscular Diseases;novel;Other Genetics;Outcome Measure;patient population;patient subsets;Patients;Peptides;Performance;Phase;Physical activity;Physiological;pre-clinical;Pre-Clinical Model;pre-Investigational New Drug meeting;preclinical study;Prediction of Response to Therapy;premature;Preparation;Probability;Process;programs;protein folding;Protein Isoforms;Proteins;Publishing;rare genetic disorder;Recombinant Proteins;Regulation;Research;Research Personnel;Research Project Grants;Research Subjects;response;Risk;Rod;Safety;safety study;Serious Adverse Event;Site;Spectrin;Structure;T cell response;T-Lymphocyte;Technology Transfer;Testing;Therapeutic;therapeutic development;Thymus Gland;Time;Toxicology;Transgenes;Translational Research;transmission process;Treatment Efficacy;triple helix;urinary;Urine;Utrophin;Validation;vector;Wheelchairs;Writing

PROJECT_TITLE: IND-enabling studies of non-immunogenic gene therapy for ultra-rare DMD patients excluded from dystrophin trials

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (18)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Intimate partner violence (IPV) is widespread in Alaska, and public health nurses play an important role in prevention, particularly in rural and underserved communities. The proposed study will leverage a practice- based research partnership with Alaska’s statewide Section of Public Health Nursing to advance the use of evidence-informed IPV prevention practices throughout the state by describing IPV practices delivered by public health nurses, identifying barriers to and facilitators of implementing IPV practices by public health nurses, and developing strategies for public health nurses to implement evidence-informed IPV practices. Findings will provide actionable information for local and state public health staff and leaders in Alaska, as well as other state and national organizations engaged in IPV prevention with rural and underserved communities.

PI_NAMEs: ADHIA, AVANTI B (contact);BEKEMEIER, BETTY

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;adverse outcome;Affect;Aggressive behavior;Alaska;Alaska Native population;Alaska Native Women;American Indians;Area;Attention;Caring;Collaborations;Communication;Communities;community partners;Consolidated Framework for Implementation Research;Country;COVID-19 pandemic;Data;Development;Discipline;Documentation;experience;Face;Focus Groups;Geography;Health;health equity promotion;Health equity research;Health Promotion;Health system;Healthcare;High Prevalence;implementation framework;implementation outcomes;implementation science;implementation strategy;Infection Control;Infrastructure;Institution;intimate partner violence;Knowledge;Legal system;lens;Maps;marginalized community;member;men;Methods;Modeling;National Institute of Nursing Research;Nurses;Pattern;Play;Practice based research;Prevalence;prevent;Prevention;prevention practice;prevention service;Prevention strategy;Process;Production;Protocols documentation;Provider;Public Health;Public Health Nursing;Public Health Practice;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Personnel;risk mitigation;Role;Rural Community;sexual violence;skills;social health determinants;societal costs;Source;Strategic Planning;System;Time;underserved community;Update;Variant;Violence;violence prevention;Woman;Work

PROJECT_TITLE: Supporting the implementation of prevention strategies by public health nurses to reduce intimate partner violence in Alaska

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: NARRATIVE Early events following inhalation of Mycobacterium tuberculosis (M.tb) in the lung play a critical role in determining whether an individual stays healthy, develops latent infection or goes on to develop active tuberculosis (TB), and HIV co-infection greatly alters these processes. Capitalizing on our discovery that M.tb exposure to lung fluids from people living with HIV greatly impacts bacterial interactions with the host, we propose to systematically evaluate early pathogenic events in the lung by combining use of several innovative models ranging from individual host cell evaluations, to multi-cellular in vitro models, a Lung on Chip model and an in vivo NHP model to dissect the microbial and host immune responses during the earliest steps of M.tb infection. We expect to identify the critical metabolic changes and cellular pathways in airway-mediated M.tb pathogenesis to advance novel approaches for the development of therapies and vaccines active in the lung.

PI_NAMEs: SCHLESINGER, LARRY S.;TORRELLES, JORDI B (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Air;Alveolar;Alveolar Cell;alveolar epithelium;Alveolar Macrophages;Alveolus;Automobile Driving;Bacterial Model;Cell Communication;Cell Death;cell envelope;Cell surface;cell type;Cell Wall;Cells;co-infection;combinatorial;Communities;Data;Development;Early Intervention;Elderly;Environment;Enzymes;eosinophil;Epithelial Cells;Evaluation;Event;experimental study;Exposure to;Granuloma;Growth;HIV;HIV Infections;HIV/TB;Human;human model;Image;Immune;Immune response;Immunity;immunological status;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infection;Inflammation;Inhalation;innovation;Intervention;latent infection;Lipids;Liquid substance;Lung;Macaca mulatta;Mediating;Metabolic;Metabolism;microbial;Modeling;monocyte;monolayer;Mucous Membrane;Mycobacterium tuberculosis;Necrosis;neutrophil;novel strategies;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Phagocytes;Play;Population;Predisposition;Primary Infection;Process;programs;Publishing;Pulmonary alveolar structure;Pulmonary Surfactant-Associated Protein D;recruit;Research;Resolution;response;Role;Science;Shapes;spatiotemporal;Surface;surfactant;Technology;Testing;therapy development;Time;tissue culture;Tissues;trafficking;Tuberculosis;Vaccines

PROJECT_TITLE: Impact of HIV on the human alveolar environment drivingthe early events of Mycobacterium tuberculosis infection


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE  It would be very helpful to have measures of the quality of mental health services to inform patients’ choice of clinicians and organizations, the training and supervision of clinicians, value-based purchasing and quality improvement efforts. Patient-reported symptoms can be electronically collected and used to study the quality of care for common depressive and anxiety disorders. This project develops and tests a new outcome- focused measure of mental health care quality that can be implemented nationally to improve services and outcomes in the community.

PI_NAMEs: YOUNG, ALEXANDER S. (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Affect;Anxiety;Anxiety Disorders;Attention;Behavioral;Benchmarking;care episode;Caring;Characteristics;Clinic;Clinical;Clinical Data;Clinical Trials;clinically significant;Cognitive;Communities;community setting;comorbidity;Competence;Data;Databases;Depressive disorder;Development;Diagnosis;Diagnostic;disparity reduction;Distress;Drug Prescriptions;Effectiveness;Electronic Health Record;Evidence based treatment;Family;health care quality;health care service organization;health equity;Health Personnel;health related quality of life;Heterogeneity;implementation outcomes;improved;improved outcome;interest;Life;Link;Measurement;Measures;Medical;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Monitor;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;practice factors;Process;Property;Provider;provider factors;Psychiatric Diagnosis;psychologic;Psychometrics;Psychotherapy;Public Health;Quality of Care;Questionnaires;rate of change;Reporting;Research;response;Risk Adjustment;service delivery;Services;Severities;social health determinants;Source;Specific qualifier value;Standardization;Structure;Study models;Supervision;symptomatic improvement;Symptoms;Syndrome;Technology;Testing;theories;Time;Training;treatment and outcome;treatment as usual;treatment effect;Treatment Factor;treatment guidelines;treatment organization;Treatment outcome;Visit

PROJECT_TITLE: An Outcome-Focused Measure of Mental Health Care Quality based on Standardized Patient-Reported Symptoms

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (05)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This project presents the first opportunity to evaluate the impact of unconditional income supplementation on pregnancy outcomes and infant development among Black birthing people in the United States, a population that experiences stark disparities and that has not seen improvements in perinatal health, despite a host of clinical intervention approaches. Evidence from non-U.S. settings suggests the potential for improvements in birth outcomes and perinatal mental health because of unconditional income supplementation, yet these settings have implemented smaller income supplements in the face of different economic contexts, approaches to health insurance, and legacies of colonialization and ongoing structural racism. The results of this study can support the advancement of income supplementation as health equity strategy to improve pregnancy outcomes and infant development.

PI_NAMEs: GOMEZ, ANU MANCHIKANTI (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: access disparities;Address;adverse outcome;adverse pregnancy outcome;Affect;Anxiety;Biological;Birth;Birth Rate;Black race;black women;California;Child Development;Chronic;Clinical;clinical practice;Communication;Communities;community based participatory approach;community based participatory research;community organizations;Consensus;Control Groups;County;COVID-19 pandemic;critical period;Data Collection;Development;Disadvantaged;Disparity;early childhood;Economics;Eligibility Determination;Emotional;Equity;Evaluation;Exclusion;experience;Exposure to;Failure;Financial Hardship;First Pregnancy Trimester;Foundations;Funding;Gestational Diabetes;Goals;Health;health equity;health inequalities;Health Insurance;Health Promotion;healthy pregnancy;Impact evaluation;Improve Access;improved;Income;Income Tax;Individual;Inequality;Inequity;Infant;Infant Development;Infant Health;Infant Mortality;Institutional Practice;Intervention;Interview;Investments;Justice;Laws;Life Cycle Stages;long-standing disparities;Longitudinal Surveys;Los Angeles;Low Birth Weight Infant;Maternal Health;maternal morbidity;Maternal Mortality;maternal stress;Measures;Mediating;Medical Records;Mental Depression;Mental Health;Methods;Motor Skills;Municipal Government;novel;Outcome;Participant;Pathway interactions;Pattern;perceived stress;perinatal health;perinatal mental health;perinatal period;Persons;Philanthropic Fund;Policies;Population;Populations at Risk;Postpartum Period;poverty reduction;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Pregnancy Outcome;Pregnancy Trimesters;pregnant;Premature Birth;Prenatal care;programs;Race;racial disparity;Random Allocation;Research;Risk;San Francisco;Second Pregnancy Trimester;Signal Transduction;Small for Gestational Age Infant;social health determinants;Stress;stress reduction;stressor;structural determinants;Structural Racism;Supplementation;Surveys;Target Populations;Taxes;treatment group;United States;uptake;Work

PROJECT_TITLE: The California Abundant Birth Project Evaluation: Advancing Birth Equity through Guaranteed Income for Pregnant People

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Recent advancements in studying transcriptional control have shed light on the roles of specific transcription factors (TFs) such as ATOH1, POU4F3, GFI1, INSM1, TBX2, and IKZF2 in inner ear hair cell (HC) development. To further this research, I propose using the newly developed inner ear organoid model to study and manipulate HC development in vitro. This project aims to identify key TFs involved in organoid HC development, create a versatile CRISPR-based toolkit for gene manipulation, and systematically investigate TF roles through CRISPR- mediated techniques and multi-omic analyses, offering key insights into HC development and aiding future regenerative research in the field.

PI_NAMEs: MATERN, MAGGIE S. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Adult;Animal Model;Animals;Auditory;Auditory system;Biological Assay;Brain;Cell Maturation;cell replacement therapy;Cell Separation;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;cost;CRISPR-mediated transcriptional activation;design;Development;Epithelium;ES Cell Line;experimental study;expression vector;flexibility;Future;Gene Activation;Gene Expression;gene network;gene repression;Generations;genetic manipulation;Genetic Transcription;GFI1 gene;Goals;Guide RNA;Hair Cells;hearing impairment;Immunohistochemistry;In Vitro;in vivo;Individual;inner ear development;Inner Hair Cells;insight;insulinoma associated 1;interest;knock-down;Labyrinth;lentivirally transduced;Lentivirus;Mammals;Mediating;Modeling;Motion;Mouse Embryonic Stem Cells;multiple omics;Mus;Mutate;nano-string;Natural regeneration;Organoids;particle;Phenotype;Play;Production;Protocols documentation;Reaction;regenerative;Regenerative research;regenerative therapy;Research;Research Personnel;Resources;RNA;RNA delivery;Role;Sensory;sound;Specific qualifier value;stem cell genes;stem cell model;Structure;Study models;Supporting Cell;Techniques;Technology;Testing;Therapeutic;tool;transcription factor;Transcriptional Regulation;Transgenic Model;transmission process;Up-Regulation;Validation;Vertebral column;Vestibular Hair Cells;vestibular system;Viral

PROJECT_TITLE: A CRISPR-based toolkit for investigating hair cell transcription factors in inner ear organoids

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Lung;Prevention;Sleep Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Obstructive sleep apnea is a highly common sleep disorder in type 1 diabetes. Adults with type 1 diabetes and sleep apnea have poorer glycemic control, but the underlying mechanisms are unclear. This research will elucidate biological and behavioral factors that may contribute to suboptimal glycemic control in adults with type 1 diabetes and sleep apnea. The results from this study may lead to novel sleep interventions and improve diabetes management in people with type 1 diabetes.

PI_NAMEs: TASALI, ESRA  (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Accelerometer;Adult;Affect;Air Pressure;Animal Model;Arousal;Basal metabolic rate;Behavior;Behavioral;Biological;Blood;blood glucose regulation;Blood Pressure;Body Composition;burden of illness;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Catecholamines;Clinical;clinical care;Complications of Diabetes Mellitus;Continuous Glucose Monitor;Continuous Positive Airway Pressure;Cross-Sectional Studies;Crossover Design;diabetes management;Diabetes Mellitus;diabetes self-management;Diagnosis;diaries;Diet Monitoring;Disease;Dose;Drowsiness;Dual-Energy X-Ray Absorptiometry;Epinephrine;Fasting;General Population;Glucagon;Glucose;Glucose Intolerance;glycemic control;Glycerol;Goals;Health Personnel;Heart Rate;high risk;Hormonal;Hormones;Hour;human model;Hydrocortisone;Hypoxia;improved;Indirect Calorimetry;Insulin;Insulin Infusion Systems;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intervention;Intervention Studies;Life;Link;lipid metabolism;Lipids;Measures;Metabolic;Nonesterified Fatty Acids;Norepinephrine;novel;novel strategies;Obstructive Sleep Apnea;Participant;Patient Self-Report;Persons;Physical activity;Polysomnography;poor sleep;prevent;primary outcome;Pump;Questionnaires;Randomized;Recurrence;Research;Resolution;Rest;Role;Scanning;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep Fragmentations;sleep quality;Sleep Stages;Slow-Wave Sleep;smartphone application;Somatotropin;Standardization;Supervision;Technology;Testing;Time;tool;treatment choice;wearable monitor;Weight;Work

PROJECT_TITLE: Obstructive sleep apnea and glycemic dysregulation in adults with type 1 diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (M2)]