ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Sulfur mustard is one of the most important chemical threats with a devastating impact on human health. Despite its ruinous history for over 100 years, there are inadequate countermeasures to treat the acute and late effects of the chemical agent. This program brings together an interdisciplinary team of scientists and clinicians to take basic findings into a clinical setting, which will facilitate our understanding and treatment for SM injury of the skin and eyes.

PI_NAMEs: LAVKER, ROBERT M;LU, KURT  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Address;Anti-Inflammatory Agents;archived data;Arts;Biological Markers;boys;Burn injury;Chemical Agents;chemical threat;Chicago;Cholecalciferol;Clinical;Clinical Trials;college;Communication;community partners;Complex;Cornea;COVID-19;Cutaneous;Data Analyses;data archive;Development;Disease;diversity and inclusion;Education;Educational workshop;efficacy evaluation;Eye;eye dryness;Eye Injuries;Eyedrops;Fostering;girls;Goals;Health;High Density Lipoproteins;Human;Hybrids;Immune;immune activation;Immunology;improved;in vivo;Inflammation;Inflammatory;Injury;innovation;Interdisciplinary Study;Investigation;Keratitis;Late Effects;Libraries;Lipids;Mechlorethamine;Mediating;medical countermeasure;medical schools;Melanins;MicroRNAs;multiple omics;Mustard;Mustard Gas;Names;nanolipoprotein particles;nanoparticle;Nanotechnology;Newsletter;nonhuman primate;novel;novel therapeutics;outreach;particle;Patient Care;Patients;Peptides;Pharmaceutical Preparations;Phase;Polymers;Positioning Attribute;programs;Property;Recording of previous events;recruit;Regimen;Research;Research Personnel;Research Project Grants;Sampling;Schools;Science;Scientist;Services;Skin;Skin injury;Societies;Sunburn;synergism;systemic intervention;Systemic Therapy;Technology;Testing;therapeutic development;Therapeutic Uses;Topical application;Training and Education;Translational Research;translational study;Translations;Universities;Woman;wound healing

PROJECT_TITLE: Barrier Damage and The Immune CascadeNorthwestern University CounterACT Center of Excellence  (NUCCX)


ADMINISTERING_IC: AR

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_STATE: IL

PI_NAMEs: LU, KURT  (contact)

PROJECT_TITLE: Core A; Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MDCN-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: JIN, PENG  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;antagonist;autism spectrum disorder;Behavioral;Biological Assay;Biological Models;Brain;candidate validation;cell type;Cells;Cerebrum;CGG repeat expansion;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Collaborations;Complex;CRISPR-mediated transcriptional activation;Data;Development;Disease;disease phenotype;drug development;Drug Modulation;drug repurposing;Drug Screening;Electrophysiology (science);Embryoid bodies;epigenome editing;Evaluation;Exhibits;Failure;FDA approved;FMR1 gene;Fragile X Syndrome;FRAP1 gene;functional loss;GABA Receptor;gamma-Aminobutyric Acid;Gene Expression Profile;Genes;Genetic;genome editing;High-Throughput Nucleotide Sequencing;Human;Human body;Human Characteristics;Human Development;human disease;human induced pluripotent stem cells;human model;improved;Individual;induced pluripotent stem cell;Inherited;inhibitor;Intellectual functioning disability;interest;kinase inhibitor;Libraries;Link;Mediating;Messenger RNA;Metabotropic Glutamate Receptors;Metformin;Methods;Modeling;Molecular;molecular phenotype;mouse model;Mus;Names;nerve stem cell;Neurons;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Organ;Organogenesis;Organoids;Outcome;Pathologic;Pathway interactions;Patients;Pharmacotherapy;Phase;Phase III Clinical Trials;Phenotype;PIK3CG gene;Pluripotent Stem Cells;pre-clinical;Property;Publishing;Regulation;Reporter;Ribosomal Protein S6 Kinase;risk variant;Role;Sampling;screening;Signal Transduction;small molecule;stem cell model;Structure;synergism;Testing;Therapeutic;Therapeutic Effect;therapeutic genome editing;therapeutic target;three-dimensional modeling;Tissues;tool;transcriptome sequencing;treatment strategy;virtual;Work

PROJECT_TITLE: Project 3


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT 3 NARRATIVE The risk of breast cancer for any individual can vary significantly. We have identified complex cell types in human breast tissue that are associated with breast cancer risk factors. In this proposal, we will establish patient-derived breast organoid cultures from normal and precancerous breast tissue to develop strategies to prevent precursor cells from developing into aggressive cancers, to determine who might benefit from these cancer prevention strategies, and ultimately to contribute to the development of a future adaptive platform trial for breast cancer prevention.

PI_NAMEs: ROSENBLUTH, JENNIFER M. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Age;Age Distribution;aggressive breast cancer;anti-cancer research;Anti-estrogen Therapy;Atypia;Back;Benefits and Risks;biobank;Biological;Biopsy;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Breast;Breast Cancer Prevention;Breast Cancer Prevention Trial;Breast Cancer Risk Factor;Breast Epithelial Cells;Cancer Biology;cancer genetics;cancer invasiveness;Cancer Model;cancer prevention;candidate identification;Cell Lineage;cell type;Cells;Cellular biology;Characteristics;Clinic;Clinical;Coculture Techniques;Complex;Core Biopsy;Cytometry;Data;Development;Disease;Environment;Estrogen receptor positive;Excision;experience;Family;Future;high risk;high risk population;High Risk Woman;Histologic;hormone therapy;Human;Image;imaging biomarker;Immunofluorescence Immunologic;Immunologic Surveillance;Immunological Models;improved;in vitro Model;Individual;Inherited;insight;Intercept;International;Intervention;Lead;Learning;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;mammary epithelium;Mammary Gland Parenchyma;Mammographic Density;Measures;Medical Oncologist;Methods;Modeling;Molecular;Mutation;New Agents;Noninfiltrating Intraductal Carcinoma;Normal Cell;novel;Operative Surgical Procedures;Organoids;Outcome;Pathway interactions;patient screening;Patients;Phenotype;Precancerous Conditions;precision medicine;precursor cell;premalignant;Premalignant Cell;prevent;Prevention;Prevention strategy;racial diversity;radiological imaging;Recording of previous events;Research;Research Personnel;response;Risk;Risk Reduction;Sampling;single cell analysis;single-cell RNA sequencing;stem cells;stressor;surveillance study;Susceptibility Gene;System;T-Cell Development;Techniques;Testing;Texture;three dimensional cell culture;Tissues;Translations;triple-negative invasive breast carcinoma;tumor;Woman;women's outcomes;young woman

PROJECT_TITLE: In vitro models as a window to learn how to change outcomes in women at high risk of developing breast cancer


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Mutations in ABCA4 are the most common form of inherited retinal degeneration causing central vision loss that can occur in children as well as in adults. Accumulation of toxic byproducts of the visual cycle can lead to cone, rod, and retinal pigmented epithelium disease and death. Using a canine model of ABCA4 early-onset disease, we will exploit a nanoparticle vector technology, already proven to efficiently target photoreceptors and RPE in rodents, to optimize treatments to permanently prevent disease onset or arrest progression at patient-relevant disease stages.

PI_NAMEs: BELTRAN, WILLIAM A. (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TERMS: 220kDa rod outer segment rim protein;achromatopsia;Address;adeno-associated viral vector;Adult;advanced disease;Affect;Alleles;Animal Model;Animals;autosome;Biology;Blindness;canine model;Canis familiaris;Cessation of life;Child;Childhood;ciliopathy;Clinic;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Complementary DNA;Cone;Defect;Development;Disease;disease natural history;disorder of macula of retina;DNA;Dose;early onset;efficacy evaluation;Endocytosis;Endosomes;Esters;Eye;Face;fluorophore;Functional disorder;Funding Mechanisms;Future;Gene Delivery;gene therapy;Gene Transfer;Genes;Genetic;Genotype;Goals;Grant;Human;immunoreaction;improved;Inherited;inherited retinal degeneration;Injections;Institution;Intervention;Joints;Knockout Mice;Knowledge;Lead;lead candidate;Length;Lentivirus Vector;Life;Lipofuscin;loss of function mutation;macular dystrophy;Marketing;Mediating;Medical;Modeling;multidisciplinary;mutant;Mutation;nanoparticle;nanoparticle delivery;Nephronophthisis;novel;novel therapeutics;Nucleic Acids;Onset of illness;Outcome Measure;outcome prediction;patient subsets;Patients;Pattern;Pennsylvania;Peripheral;Persons;Phase;Phenotype;photoreceptor degeneration;Photoreceptors;plasmid DNA;Plasmids;preclinical study;Preparation;prevent;programs;promoter;Rattus;Research;Research Personnel;research study;Retina;Retinal Degeneration;Retinal Diseases;Retinal gene therapy;Retinaldehyde;Rod;Rodent;Route;RPE65 protein;RPGR gene;Scientist;Solid;spatiotemporal;Stargardt's disease;Structure of retinal pigment epithelium;subretinal injection;success;System;Technology;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;Time;transduction efficiency;Transfection;Translational Research;treatment effect;treatment optimization;trend;Universities;Validation;vector;Vertebral column;Vertebrate Photoreceptors;Vision;Visual;visual cycle

PROJECT_TITLE: Translational Research for Retinal Degeneration Therapies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Physical Injury - Accidents and Adverse Effects

PHR: Narrative The overall goal of the Lipid-Based Self-Assembled Materials and Characterization Core (LBSAMCC) is to synthesize, characterize, and deliver novel therapeutics to each of the Projects focused on treating eye and skin exposure to toxic mustards. The LBSAMCC is expert in the synthesis and translation of bioinspired materials that specifically target relevant eye and skin cells, including epithelial and inflammatory cells, and function to ameliorate the devastating effects of nitrogen and sulfur mustard exposure.

PI_NAMEs: THAXTON, COLBY SHAD (contact)

PROJECT_TERMS: Address;Affinity;Anti-Inflammatory Agents;Apolipoprotein A-I;arm;Binding;Biological;Biological Process;Biological Products;Cell model;cell type;Cells;cellular imaging;Chemicals;Chemistry;Cholecalciferol;Cholesterol;Clinic;Collaborations;Cream;Data;Development;Diameter;Drug Delivery Systems;drug release profile;Epithelial Cells;Epithelium;Exposure to;Eye;Eye Injuries;Eyedrops;flexibility;Formulation;Generations;Goals;Gold;healing;High Density Lipoproteins;Hydrogen Bonding;hydrophilicity;Hydrophobicity;Imaging Techniques;Immune;in vivo;in vivo evaluation;Inflammation;Inflammatory;Infrastructure;Injury;Innate Immune System;keratinocyte;keratinocyte differentiation;Libraries;lipid metabolism;Lipids;Location;Mechlorethamine;Methods;MicroRNAs;Mustard;Mustard Gas;nanoGold;nanoparticle;nanotherapeutic;novel;novel therapeutics;Nucleic Acids;Organic Synthesis;Pathway interactions;Peptides;Pharmaceutical Preparations;Phospholipids;Process;Property;Proteins;receptor;remediation;scaffold;scavenger receptor;screening;self assembly;Serum;severe injury;Skin;Skin injury;Small Interfering RNA;small molecule;Solid;Sterols;Structure;Surface;targeted treatment;technology platform;Therapeutic;Topical application;Translations;Universities;uptake;Vitamin D;Work;wound healing

PROJECT_TITLE: Lipid Based Self Assembled Materials Synthesis and Characterization


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Machine Learning and Artificial Intelligence;Microbiome;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: HOSPITAL FOR SICK CHLDRN (TORONTO)

ORG_STATE: ON

ORG_ZIPCODE: M5G 1X8

PHR: PROJECT NARRATIVE Early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (VLBW), but current feeding protocols do not optimally support these vulnerable infants. The Opti-NuM Project will leverage the world’s most comprehensive clinical nutrition database and biobank for VLBW infants to analyze the nutrient and non-nutrient components of human milk consumed by this population. We will apply a unique systems biology approach combining multi–omics technologies and machine learning to develop a “precision nutrition” approach for human milk-fed VLBW infants to optimally support their short- and long-term health.

PI_NAMEs: AZAD, MEGHAN BRIANNE;O'CONNOR, DEBORAH  (contact);UNGER, SHARON

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acceleration;Address;adverse outcome;American;Bacteria;Bifidobacterium;biobank;biological systems;Birth;Blood;Body mass index;Butyrates;Cells;Child;Clinical;Clinical Data;Clinical Nutrition;Cognition;Collaborations;Complex;Consumption;Country;Data;Data Scientist;Data Set;Databases;Development;Diet;DNA;Doctor of Philosophy;donor milk;enteric pathogen;Enterocolitis;evidence base;Feces;feeding;follow-up;Genetic;Goals;Grant;Growth;Growth and Development function;Growth Factor;gut microbiome;gut microbiota;Health;high risk infant;Hospitalization;Hour;Human Milk;human milk oligosaccharides;Hydrocortisone;Immunologic Factors;improved;Infant;Infant Health;innovation;Intake;interest;International;Life;Machine Learning;machine learning method;machine learning pipeline;Macronutrients Nutrition;Measures;microbial;microbial composition;microbiota;Micronutrients;Milk;Milk Substitutes;Modeling;Morbidity - disease rate;multidisciplinary;multiple omics;Neonatal;neurodevelopment;Neurologic;novel;Nutrient;nutrition;Nutritional;Outcome;Parents;Plasma;polygenic risk score;Population;precision nutrition;predictive modeling;prevent;programs;Protocols documentation;Questionnaires;Research;Research Personnel;Resources;Risk;Role;Sampling;Sepsis;sex;Shapes;Single Nucleotide Polymorphism;Source;Stress;Subgroup;Systems Biology;Technology;Time;Titrations;Very Low Birth Weight Infant;Vulnerable Populations;Weight

PROJECT_TITLE: Improving growth and neurodevelopment of very low birth weight infants through precision nutrition: The Optimizing Nutrition and Milk (Opti-NuM) Project.


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PHR: Project Narrative Advanced polymeric materials already play a significant role in biomedical applications. With advances in biocompatible polymers, biohybrid materials and biopolymer mimics, we are in a position to translate these materials for applications in mustard gas mitigation in the eyes and skin. We will apply advanced synthesis and characterization tools from chemistry and materials science, in close collaboration with Projects 1-3, to build a pipeline of innovative materials platforms and specific technologies for these applications.

PI_NAMEs: GIANNESCHI, NATHAN CLAUDE (contact)

PROJECT_TERMS: Adsorption;Amino Acids;Angiogenesis Inhibitors;Angiogenic Peptides;Anti-Inflammatory Agents;Binding;biocompatible polymer;biodegradable polymer;Biological Assay;Biopolymers;carboxylate;Cell Culture Techniques;Cells;Charge;Chemical Injury;Chemicals;Chemistry;Clinical;clinical translation;Clinical Trials;Collaborations;cytokine;direct application;Encapsulated;experimental study;Exposure to;Exudative age-related macular degeneration;Eye;Film;Formulation;Free Radical Scavenging;Glycolates;Goals;Human;Immune;Immunology;improved;In Vitro;in vivo;Inflammation;Inflammatory;innovation;interest;Interleukin-10;Intravenous infusion procedures;keratinocyte;Laboratories;Lead;lead candidate;Lipids;Liquid substance;Macrophage;materials science;Mechlorethamine;Melanins;Microbiology;Modeling;Modification;monocyte;monomer;Mustard;Mustard Gas;nanomaterials;nanoparticle;Nature;novel;particle;Peptides;Play;Polymers;Porosity;Positioning Attribute;Preparation;Production;Property;protein aminoacid sequence;Proteins;Redness;remediation;Retina;Role;scale up;self assembly;Site;Skin;skin burn;Skin injury;small molecule;Solubility;Surface;surface coating;System;Technology;technology platform;Testing;Therapeutic;therapeutic nanoparticles;tissue injury;Tissues;tool;Transforming Growth Factor beta;Translating;ultraviolet irradiation;Universities;uptake;Validation;Vitamin D;Work

PROJECT_TITLE: Polymeric Materials Synthesis and Characterization


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: This is a Phase III clinical trial to establish the efficacy of progressive high-intensity, endurance treadmill exercise to slow the progression of the signs of Parkinson's disease (PD). If successful, this study will have a significant impact on the quality of life of people with PD and their caregivers as well as public health since it will slow progression of the signs of PD. Establishing high-intensity endurance treadmill exercise as a means to slow the progression of the signs of the disease would mark a significant breakthrough in treating PD and would have a significant public health impact.

PI_NAMEs: CORCOS, DANIEL M. (contact)

PROGRAM_OFFICER_NAME: MENDOZA-PUCCINI, MARIA CAROLINA

PROJECT_TERMS: Adverse event;Aerobic;Animal Model;Attenuated;Binding;Biological Markers;Blood;Brain-Derived Neurotrophic Factor;C-reactive protein;Caregivers;Caring;Clinical;clinical application;Cognition;cognitive function;Corpus striatum structure;Data;design;Diagnosis;Disease;dopaminergic neuron;dosage;Dose;efficacy trial;endurance exercise;epidemiologic data;Exercise;exercise prescription;exercise regimen;Feasibility Studies;fitness;Futility;Gait;Goals;Heart Rate;human data;improved;Inflammation;Investigation;Levodopa;Literature;Masks;Maximum Heart Rate;Measures;Moderate Exercise;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Neurologist;neurotrophic factor;Parkinson Disease;Participant;Patient Self-Report;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phase II Clinical Trials;Phase III Clinical Trials;phase III trial;Physiological;pre-clinical;Public Health;Quality of life;Randomized;Research Design;Safety;side effect;Signs and Symptoms;Site;Specificity;Testing;Therapeutic;Time;translational study;treadmill;treadmill training;treatment as usual;VO2max;Waiting Lists;Walking

PROJECT_TITLE: Study in Parkinson Disease of Exercise Phase 3 Clinical Trial: SPARX3

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders K Study Section[NSD-K]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Mental Health;Microbiome;Neurosciences;Nutrition;Pediatric;Pregnancy;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative In utero exposure to maternal inflammation caused by environmental factors, such as diet, affects offspring susceptibility to neurodevelopmental disorders; yet, the underlying mechanisms remain unclear. High-fat diets alter the functional composition of the gut microbiome, which is emerging as a major influence on host physiology, including fetal immune maturation and neurodevelopment. The goal of this project is to understand whether and how high-fat diet-induced dysbiosis of the maternal gut microbiome during pregnancy contributes to abnormal fetal epigenetic programming underlying neurobehavioral dysfunction across multiple descendant generations, and to determine the potential for therapeutic modulation of the maternal gut microbiome during pregnancy to prevent adverse neurobehavioral outcomes in descendants.

PI_NAMEs: BUFFINGTON, SHELLY A (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Adoptive Transfer;Adverse effects;Affect;antenatal care;associated symptom;ATAC-seq;autism spectrum disorder;Behavior;Behavior assessment;Behavioral;Behavioral Symptoms;Brain;Brain region;Businesses;CD4 Positive T Lymphocytes;Cell Maturation;Cell Separation;cell type;Chronic Disease;Consensus;Coupled;critical period;cytokine;Data;Development;Diet;discrete time;Disease;Disease susceptibility;dysbiosis;Embryo;Environmental Risk Factor;Epigenetic Process;experience;Exposure to;Family;fecal transplantation;Female;fetal;Fetal Development;fetal programming;Functional disorder;gastrointestinal symptom;Generations;Genetic Predisposition to Disease;Germ-Free;Goals;gut dysbiosis;gut microbiome;gut microbiota;Health;High Fat Diet;Human;Hypothalamic structure;Immune;immune activation;immune function;Impairment;imprint;improved;in utero;Individual;Industrialization;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Interdisciplinary Study;Intervention;Life;male;maternal microbiome;Mediating;Metabolic syndrome;metabolome;metabolomics;Metagenomics;microbial;microbiome;microbiome composition;microbiota transplantation;Mus;neural circuit;neurobehavioral;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neuroinflammation;neuropathology;neuropsychiatric disorder;neuropsychiatry;offspring;Outcome;Pathologic;Pathology;Pathway interactions;patient population;Peptide Initiation Factors;Personal Satisfaction;Phenotype;Physiology;Population;Predisposition;Pregnancy;prenatal exposure;prevent;Probiotics;Process;Rag1 Mouse;Recovery;Reporting;Rewards;Schizophrenia;Serum;sex;sexual dimorphism;social;Social Behavior;social deficits;Social Interaction;Synaptic plasticity;Testing;Therapeutic;therapeutic target;transcriptome sequencing;Volatile Fatty Acids;Whole-Genome Shotgun Sequencing;women versus men;Work

PROJECT_TITLE: Maternal gut microbiota in fetal programming of neurodevelopment and related disorders

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative: In this project, we use precise genome editing to generate novel mouse models, recapitulating p63 mutations that cause human EEC syndrome (Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate). We will use systems biology tools to examine gene regulatory networks affected by these p63 mutations during skin development and hair morphogenesis. Knowledge gained from the proposed studies will help to identify the mechanisms associated with human birth defects caused by p63 mutations and provide new insights into how point mutations in the DNA binding domain of a transcription factor selectively affect enhancer functions.

PI_NAMEs: YI, RUI  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Adult;Affect;Alleles;appendage;Basement membrane;Binding;Biological Process;Cell Adhesion;Cell Lineage;Child;Chromatin;cleft lip and palate;Cleft Palate;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;computerized tools;Congenital Abnormality;CRISPR/Cas technology;Data;Defect;Development;Developmental Biology;DNA Binding Domain;Dryness;Ectodermal Dysplasia;ectrodactyly-ectodermal dysplasia-clefting syndrome;Embryonic Development;Enhancers;Epithelial Cells;epithelial stem cell;Epithelium;Etiology;Event;Extracellular Matrix;Failure;foot;Gene Expression;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Models;Genetic Transcription;Genome;Genomics;Goals;Growth;Hair;Hair follicle structure;Hand;Heterozygote;Homo;Human;Human Development;Hypopigmentation;Impairment;in vivo;Individual;insight;Knock-in;Knowledge;Limb Development;loss of function;Maintenance;malformation;Mediating;Mesenchymal;Messenger RNA;Mission;Modeling;Molecular;Morphogenesis;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;National Institute of Child Health and Human Development;Natural regeneration;Neonatal;novel;novel therapeutics;orofacial cleft;Patients;Phenotype;Point Mutation;precise genome editing;promoter;Reporting;Research;Role;Scalp structure;Signal Pathway;Signal Transduction;single cell analysis;single cell ATAC-seq;single cell genomics;single cell technology;single-cell RNA sequencing;Skin;skin organogenesis;Specific qualifier value;stemness;Structural Congenital Anomalies;success;Syndrome;System;Systems Biology;Testing;Tissues;tool;transcription factor;transcriptome;WNT Signaling Pathway

PROJECT_TITLE: Modeling p63-associated human birth defects with systems developmental biology approaches

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures

PI_NAMEs: RANGEL, STEPHANIE M (contact)

PROJECT_TERMS: Advocacy;Area;Arts;Astronomy;Awareness;Biology;Biomedical Research;boys;Career Choice;chemical threat;Chemistry;Chicago;college;Communication;Communities;community engagement;Community Outreach;community partners;Coupled;Data;Dermatology;design;Development;Discipline;Disease;diversity and inclusion;Education;Educational Curriculum;Educational workshop;Electronic Mail;elementary school;Evaluation;Faculty;Fostering;girls;Goals;Grant;Illinois;Immune;Immune response;Immunology;improved;Injury;innovation;Knowledge;Leadership;learning progression;medical schools;Medical Students;Medicine;Middle School Student;Minority;Mission;multidisciplinary;Mustard;Ophthalmology;Outcome;outreach;Participant;Physics;Postdoctoral Fellow;programs;recruit;Research;Research Personnel;Resources;Schools;Science;Scientist;Series;sex;skills;Skin;Slide;Societies;success;Toxicology;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Minority;Universities;Urology;web site;Woman

PROJECT_TITLE: Education and Enrichment Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative This training grant clearly has major relevance in public health as it is designed to train the next wave of biostatistical researchers in cancer genomics, which is one of the largest and growing areas of biomedical research, in which the demand for well trained biostatistical researchers is much greater than the supply.

PI_NAMEs: IBRAHIM, JOSEPH G (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Biostatistics for Research in Genomics and Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Kidney Disease;Lupus

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Lupus nephritis, an autoimmune kidney disease characterized by a T and B lymphocyte infiltrate, is associated with significant morbidity and mortality yet no targeted treatments exist. This proposal will investigate the function of kidney-infiltrating B lymphocytes and determine how B lymphocyte survival and function are influenced by the high sodium concentrations found in the kidney tissue environment. The work will utilize both animal models and human kidney biopsies and will help identify kidney-specific targets for the treatment of lupus nephritis.

PI_NAMEs: CHERNOVA, IRENE  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Affect;Animal Model;Animals;Antibodies;Antibody Formation;Antigen-Presenting Cells;Autoimmune;Autoimmune Diseases;Award;B-Lymphocytes;Bathing;Bioinformatics;Biopsy;Bone Marrow;career;career development;Cell Death;Cell Physiology;Cell Survival;Cells;Cessation of life;Chimera organism;cytokine;Data;Deposition;design;Development;Development Plans;Dissection;Diuretics;End stage renal failure;Energy Metabolism;Environment;Exhibits;experimental study;Experimental Water Deprivation;Exposure to;Flow Cytometry;Fluorescent in Situ Hybridization;Gene Modified;Generations;Genetic;Genetic Transcription;Geography;Goals;Grant;high salt diet;Human;Imaging Techniques;Immunobiology;Immunofluorescence Immunologic;Immunohistochemistry;Immunology;In Situ;in situ imaging;in vivo;Infiltration;Institution;interstitial;ionic balance;Ions;Kidney;kidney biopsy;kidney cortex;Kidney Diseases;kidney medulla;Knock-out;Lupus;Lupus Nephritis;lupus prone mice;Lymphocyte;Lymphocytic Infiltrate;Manuscripts;Measures;Mediating;medical schools;Mentorship;Morbidity - disease rate;mortality;Mus;Na(+)-K(+)-Exchanging ATPase;Nephritis;Nephrology;novel;Organ;Pathogenesis;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Physicians;Population;Positioning Attribute;Preparation;Production;programs;Proteinuria;Renal function;Research;Research Personnel;RNA;Scientist;Serum;Severity of illness;Shapes;Sodium;statistics;Stress;systemic autoimmune disease;Systemic Lupus Erythematosus;T-Lymphocyte;TAC1 gene;Technology;Testing;Tissues;Universities;Water;Wild Type Mouse;Work

PROJECT_TITLE: The Effect of Sodium (Na+) on Kidney B cells in Lupus Nephritis


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Prevention;Wound Healing and Care

PHR: PROJECT NARRATIVE Information from this project will enhance our understanding of how to effectively treat skin blistering and secondary immune reactions after exposure of sulfur mustard to the skin. There is a need for novel drugs that can comprehensively treat both the chemical burn and life-threatening internal organ damage. This highly translational approach blocks and dampens hyper-reactive immune responses using novel topical and systemic treatments to promote repair.

PROJECT_TERMS: Acceleration;Acute;Adsorption;Alkylating Agents;Animal Model;Anti-Inflammatory Agents;Apoptosis;Binding;Biological;Biological Markers;Biological Process;biomaterial compatibility;Blood Cells;Bone Marrow;Bulla;carboxylate;CCL2 gene;CCL3 gene;Cells;Chemical Burns;Chemical Warfare Agents;Chemicals;Chemotactic Factors;Cholecalciferol;Cholesterol;Chronic;Cicatrix;Combined Modality Therapy;Complement;cytokine;cytokine release syndrome;cytopenia;Data;Development;DNA;DNA Damage;Dopamine;Dose;Drops;Edema;efficacy study;efficacy testing;Epidermis;Epithelium;Event;Fibroblasts;Free Radicals;Glycolates;Goals;High Density Lipoproteins;Immune;immune activation;Immune response;Immunology;immunoreaction;immunoregulation;In Vitro;in vivo;individualized medicine;Induration;Inflammation;Inflammatory;Inflammatory Infiltrate;Infusion procedures;Injury;innovation;Interferons;Intervention;intravenous administration;Investigation;ITGAM gene;Late Effects;Life;Liver;macromolecule;Macrophage;Marketing;Mechlorethamine;Melanins;MMP9 gene;Modeling;monocyte;mortality;Mustard;Mustard Gas;nanolipoprotein particles;nanoparticle;Nanotechnology;neutralizing antibody;neutrophil;NF-kappa B;novel;novel therapeutics;Organ;particle;Patients;Pharmaceutical Preparations;Pigments;Porosity;prevent;Process;Property;re-epithelialization;Reaction;Recovery;Regimen;repaired;scavenger receptor;side effect;Signal Transduction;Site;Skin;skin barrier;skin burn;skin damage;Skin injury;skin wound;small molecule;Spleen;Swelling;synergism;systemic intervention;Testing;Therapeutic;Time;tissue injury;Tissues;TNF gene;Topical application;Toxic effect;Toxin;Transforming Growth Factor beta;translational approach;Ultraviolet Rays;Universities;UV protection;Weight;World War I;wound;wound healing

PROJECT_TITLE: Topical and systemic interventions for mustard-induced skin injury


NIH_SPENDING_CATS: Biomedical Imaging;Genetics;Machine Learning and Artificial Intelligence;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_DEPT: GENETICS

PHR: Narrative Stem cells have the unique ability to replenish both themselves and the specialized cell types of our organs. Dysregulation of this balance leads to diverse diseases, such as fibrosis and cancer, that lack effective treatments. We use novel microscopy approaches to study this balance in the skin in live animals, which allows us to discover previously unknown mechanisms that sustain our organs, how these mechanisms go awry in disease, and potential therapeutic strategies to restore balance.

PI_NAMEs: GRECO, VALENTINA  (contact)

PROJECT_TERMS: Animals;Architecture;Basal Cell;Behavior;Calcium;Calcium Signaling;cell behavior;Cell Communication;Cell Cycle;cell type;Cells;Chromatin;Chromatin Structure;Complex;Data;Degenerative Disorder;Differentiation Antigens;Disease;effective therapy;Ensure;epidermal stem cell;Epidermis;Epithelial Cells;Epithelium;Equilibrium;Event;Failure;Fibrosis;Genetic;Genetic Transcription;Grant;Homeostasis;Image;imaging approach;Imaging Techniques;Imaging technology;improved;innovation;intravital imaging;Machine Learning;Maintenance;Malignant Neoplasms;Mammals;Methods;Microscopy;Molecular;Morphology;mouse genetics;Natural regeneration;novel;Organ;Pattern;pharmacologic;Play;Population;Process;programs;Public Health;Reporter;Research;response;Role;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin regeneration;stem;stem cell biology;stem cell differentiation;stem cell fate;stem cell model;stem cell self renewal;stem cells;stemness;Stratum Basale;System;temporal measurement;Testing;Therapeutic;Time;Tissues;tool;Tracer;transcriptomics;unsupervised learning;Visualization;wound healing

PROJECT_TITLE: Live Imaging of Skin Regeneration

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

PHR: PROJECT NARRATIVE Information from this project will enhance our understanding of how to effectively treat the vision-threatening consequences of sulfur mustard (SM) injury to the eyes. There is an immediate need for the development of novel non-steroidal treatments. Innovative topical and systemic treatments that enhance corneal re- epithelialization and ameliorate corneal inflammation and angiogenesis, with minimal side effects, are essential for maintaining proper vision following SM injury.

PI_NAMEs: LAVKER, ROBERT M (contact)

PROJECT_TERMS: Acute;acute symptom;Adverse effects;Affect;Aftercare;analog;angiogenesis;Angiogenesis Inhibitors;Anterior;Anti-Inflammatory Agents;Attenuated;Autophagocytosis;Binding;Biological;Cells;Characteristics;Chemical Burns;Chemical Warfare Agents;Cholecalciferol;Clinical;Collagen;Complex;Cornea;corneal epithelium;Corneal Injury;Corneal Neovascularization;cytokine;Data;Defect;delivery vehicle;Deterioration;Development;Dyes;efficacy evaluation;Epithelium;Evaluation;Exclusion;Exposure to;Eye;Eye Injuries;Eyedrops;Film;Fluorescein;Funding;Glycolates;healing;High Density Lipoproteins;Immune;Immunologics;improved;Inflammation;Inflammatory;inflammatory marker;Injury;innovation;Ischemia;Knowledge;Laboratories;Light;limbal;Lipids;Mechlorethamine;microRNA delivery;MicroRNAs;Modality;Morphology;Mus;Mustard Gas;nano;nanolipoprotein particles;nanoparticle;neovascularization;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;ocular surface;Oryctolagus cuniculus;particle;patient subsets;Patients;Penetration;Peripheral;Phase;Phenotype;preservation;prevent;Protocols documentation;re-epithelialization;Regimen;response;scaffold;screening program;side effect;Signal Transduction;Stains;stem cells;Steroids;Stress;Surface;System;Testing;Therapeutic;Thinness;Tissues;Topical application;translational potential;Universities;Variant;Vision;wound healing

PROJECT_TITLE: Reversing the ocular impact of NM and SM through novel therapies


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE Tobacco taxes are widely used and demonstrably effective in reducing mortality and morbidity including cancer related outcomes, but they may exacerbate tobacco-related socioeconomic disparities. This project will develop and test the health equity of an abuse liability dependent tax proposal in a sample of cigarette smokers from diverse socioeconomic background. The findings of this project will elucidate a novel tax proposal designed to reduce tobacco dependence and tobacco-related disparities.

PI_NAMEs: FREITAS LEMOS, ROBERTA  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: abuse liability;Acceleration;addiction;Address;age stratification;attributable mortality;behavioral economics;cancer health disparity;career development;Categories;Cessation of life;Cigarette;Cigarette Smoker;comparison control;Complex;consumer behavior;Consumption;Data;design;Development;Development Plans;Disparity;Drug Kinetics;Environment;Equity;experience;Experimental Models;Exposure to;Goals;Government;Health;health equity;Health Policy;Incidence;Individual;innovation;insight;intervention effect;Laboratories;Malignant Neoplasms;Medicine;meetings;Mentored Research Scientist Development Award;Mentors;Meta-Analysis;Methods;Morbidity - disease rate;mortality;Nicotine;novel;Outcome;Participant;Pattern;Pharmacodynamics;Policies;Prevalence;Price;programs;prospective;Public Health;public policy on tobacco;recruit;reduce tobacco use;Regulation;Research;Research Personnel;Research Priority;Resources;Risk;Sampling;Smokeless Tobacco;Smoker;socioeconomic disparity;Socioeconomic Status;socioeconomics;Statistical Methods;Stimulus;Structure;systematic review;Taxes;Technical Expertise;Testing;Tobacco;tobacco abuse;tobacco control;Tobacco Dependence;tobacco products;Tobacco smoke;Tobacco use;Tobacco-Related Carcinoma;Training;Translations;Virginia

PROJECT_TITLE: Development of abuse liability-based tobacco tax proposals: Experimental impact on tobacco-related socioeconomic cancer health disparities

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_NAME: FESARIUSTHERAPEUTICS, INC.

ORG_STATE: NY

PHR: NARRATIVE When autologous tissue is not available or split thickness skin grafts alone are used, full thickness skin loss may not heal or will heal by contracture of the surrounding skin. Current treatment approaches including engineered off the shelf products have significant limitations, including slow, inconsistent, and inadequate tissue formation, hence impaired wound healing. The commercialization of DermiSphereTM is expected to improve clinical practice in surgical fields where full thickness skin loss is common including, but not limited to, trauma, burns, and post- oncologic reconstructive surgery, by significantly decreasing the time required to achieve a healed wound, as well as increasing the thickness of the regenerated dermis in a scenario of full thickness skin loss.

PI_NAMEs: SAPIR LEKHOVITSER, YULIA  (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Acceleration;Address;angiogenesis;Architecture;Area;Autologous;Autologous Transplantation;Biological Assay;Burn injury;Care given by nurses;Cattle;Cells;Cellular Infiltration;Clinical;clinical practice;Collagen;commercialization;Complication;Contracture;Cues;Cyclic GMP;Dermal;Dermis;design;Development;Devices;Engineering;Ensure;Expenditure;Failure;flexibility;healing;Healthcare;Human;Hydration status;Immobilization;Impaired wound healing;Implant;implantation;improved;Incidence;Infection;infection risk;Infiltration;innovation;instrument;Life;manufacture;manufacturing capabilities;manufacturing process;Marketing;microbial;Morbidity - disease rate;Natural regeneration;Operative Surgical Procedures;Patients;Performance;Preclinical Testing;Preparation;prevent;Procedures;Process;product development;Production;Protocols documentation;prototype;Qualifying;Readiness;Reconstructive Surgical Procedures;Reporting;resilience;Resources;response;scaffold;Site;Skin;Skin graft;skin regeneration;Specific qualifier value;standard care;Sterilization;System;Technology;Tendon structure;Testing;Therapeutic;Thick;Thinness;Time;Tissues;Trauma;United States Centers for Medicare and Medicaid Services;Validation;Vascularization;Viral;wound;wound bed;wound healing

PROJECT_TITLE: DermiSphere™: An Advanced Dermal Regeneration Scaffold for Reconstructive Surgery, CRP


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Physical Injury - Accidents and Adverse Effects

PHR: PROJECT NARRATIVE Information obtained from this project will validate and define key biomarkers in response to mustard gas exposure. The innovation for this project is the experimental setup that permits testing with discarded human tissue coupled with insights drawn from clinical medicine. The findings will enable the translation and discovery of new countermeasures for mustard gas injury.

PI_NAMEs: LU, KURT  (contact)

PROJECT_TERMS: absorption;Acute;Address;Alkylating Agents;Animal Model;Animals;Antimetabolites;Apoptosis;Area;Binding;Biological Markers;Biology;biomarker signature;Blood;Body Surface Area;Bone Marrow Suppression;Bulla;Caring;Cell Death;Cells;Cessation of life;Cholecalciferol;Clinical;Clinical Medicine;Clinical Trials;Complex;Coupled;cytokine;Dermatologic;Development;Disease;DNA biosynthesis;DNA Damage;Dose;Edema;efficacy evaluation;efficacy testing;Epithelium;Erythema;experience;exposed human population;Exposure to;Foundations;Goals;Harvest;Human;Human Subject Research;human tissue;Immune;immune activation;immune cell infiltrate;Immune mediated destruction;Immune system;Immunophenotyping;in vivo;Induration;Inflammation;Inflammatory;information gathering;injured;Injury;innovation;insight;Macrophage;Mechlorethamine;Mediating;medical countermeasure;Medicine;MMP9 gene;Modeling;molecular marker;Molecular Profiling;Molecular Target;monocyte;Mustard;Mustard Gas;nonhuman primate;novel;Outcome;Outcome Measure;particle;Patients;peripheral blood;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;premalignant;prevent;Production;Reaction;receptor;Redness;release factor;Resources;response;Role;Signal Transduction;Skin;skin barrier;skin biopsy;skin cancer prevention;Skin injury;Skin Manifestations;Source;standard of care;Surface;Swelling;Technology;Testing;Time;Tissue Banks;tissue injury;Tissues;TNF gene;transcriptome sequencing;Transforming Growth Factor beta;Translations;Treatment Protocols;Universities;Vesicants;Vitamin D

PROJECT_TITLE: Translation & trials: advancing medical countermeasure development


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Our sense of light touch underlies our ability to detect and discriminate a wide range of tactile stimuli, but the mechanisms by which the central nervous system integrates inputs from primary sensory neurons remain elusive. This proposal will advance our understanding of tactile perception through exploration of how somatosensory signals are organized within the dorsal column nuclei (DCN) of the brainstem for output to brain regions with distinct functions.

PI_NAMEs: HUEY, ERICA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Address;Afferent Neurons;Amyloid beta-Protein;anatomical tracing;Animals;Axon;body map;Brain;Brain region;Brain Stem;Calcium;Cell Nucleus;Cells;Central Nervous System;Clinical;Complex;Cutaneous;Discrimination;dorsal column;Environment;Exhibits;experimental study;extracellular;Fiber;genetic approach;Hypersensitivity;Image;in vivo;Individual;individuals with autism spectrum disorder;Inferior Colliculus;information processing;insight;Instinct;Interneurons;Investigation;Light;Logic;Maps;Measures;mechanical allodynia;Mechanical Stimulation;Mechanoreceptors;Methods;Motor;neural prosthesis;Neurons;novel;object recognition;Opsin;Optics;Output;Pathway interactions;Perception;Peripheral;Peripheral nerve injury;Physiology;Population;Process;Property;receptive field;response;Sensory;sensory integration;Signal Transduction;Site;Skin;Slice;Social Interaction;somatosensory;Somatosensory Cortex;Spinal Cord;Spinal Cord Column;Stimulus;Stream;Synapses;Tactile;Target Populations;Thalamic structure;tool;Touch sensation;transmission process;two-photon;Whole-Cell Recordings;Work

PROJECT_TITLE: Divergence of Tactile Processing in the Dorsal Column Nuclei


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: FRESNO

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FRESNO

PHR: Narrative  The Bridges to Doctorate program between the California State University, Fresno (Fresno State) and the University of California, Davis (UC Davis) will offer a range of curricular, research, and co-curricular activities for five Bridges graduate scholars each year to develop a pipeline for graduate students to successfully get accepted into Ph.D. programs in biomedical sciences. Fresno State is in the San Joaquin Valley (SJV) in California's Central Valley, one of the most rapidly growing culturally and ethnically diverse yet underserved areas in California. By working together with the faculty, members in the College of Science and Mathematics at Fresno State and faculty from UC Davis will create a highly interactive program to promote access to research careers to under-represented ethnic minorities and ease the transition of these students into Ph.D. programs.

PI_NAMEs: CARVAJAL CARMONA, LUIS GUILLERMO;KRISHNAN, VISWANATHAN V (contact);LAM, KIT S

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: bridge to the doctorate;programs

PROJECT_TITLE: Bridges to Doctorate Program between Fresno State and UC Davis

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Calcium signaling plays a central role in pancreatic β cell function, and alterations in β cell calcium signaling are observed in both major forms of diabetes. Ryanodine receptors are large-conductance calcium release channels in the endoplasmic reticulum membrane. The proposed research will define how ryanodine receptor dysfunction in the β cell contributes to diabetes pathophysiology and will test the hypothesis that the ryanodine receptor serves as a critical hub in the pancreatic β cell, regulating calcium dynamics, insulin secretion, and cell survival.

PI_NAMEs: EVANS-MOLINA, CARMELLA  (contact);JOHNSON, JAMES DANIEL;SLAK RUPNIK, MARJAN

PROGRAM_OFFICER_NAME: LAUGHLIN, MAREN R

PROJECT_TERMS: Acceleration;Address;Age;Alleles;Apoptosis;Beta Cell;Biophysics;blood glucose regulation;Bolus Infusion;Ca(2+)-Transporting ATPase;Calcium;Calcium Channel;calcium indicator;Calcium Oscillations;Calcium Signaling;Cell Death;Cell membrane;Cell Physiology;Cell Survival;Cells;Cellular biology;Closure by clamp;Complex;Data;Data Science;Detection;Diabetes Mellitus;diet-induced obesity;disease model;Electrophysiology (science);Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Event;experimental study;Failure;Functional disorder;Genes;Genetic;Glucose;Glucose Intolerance;glucose tolerance;Health;Human;Image;imaging approach;imaging modality;impaired glucose tolerance;improved;In Vitro;in vivo;Individual;inducible Cre;Inflammatory;Inositol;Insulin;insulin regulation;insulin secretion;intravital imaging;intravital microscopy;Ion Channel;islet;ITPR1 gene;Knock-out;Knockout Mice;Knowledge;light microscopy;Link;Maintenance;Mass Spectrum Analysis;Measures;Mediating;Membrane;Membrane Potentials;Messenger RNA;Metabolic;Metabolic stress;mitochondrial metabolism;Modeling;Molecular;Monitor;Morphology;mouse model;multidisciplinary;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Organelles;Pancreas;Pattern;pharmacologic;Physics;Physiological;Physiology;Play;Process;Production;Proliferating;Protein Isoforms;Proteins;Proteomics;Publishing;Pump;quantitative imaging;Quantitative Reverse Transcriptase PCR;Rattus;Reagent;receptor;Regulation;Reproducibility;Research;response;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Shapes;Signal Transduction;Slice;Stress;Structure of beta Cell of islet;temporal measurement;Testing;Tissues;tool;tripolyphosphate;two-photon;type I and type II diabetes;uptake;voltage;voltage clamp;Work

PROJECT_TITLE: Control of beta cell function and survival by RYR2-mediated calcium signals

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Natural Products

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: The emergence of multidrug-resistant Gram-negative bacteria has compromised our ability to treat infections. Studies in this proposal build on novel chemical synthesis to explore variants of a natural product called strepothricin to provide a new therapy to treat these very problematic pathogens.

PI_NAMEs: KIRBY, JAMES E (contact);MANETSCH, ROMAN ;YU, EDWARD W

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acetylation;Acinetobacter baumannii;Amines;Aminoglycosides;analog;Anti-Bacterial Agents;Antibiotic Resistance;antimicrobial;Bacterial Infections;bactericide;Binding;Binding Sites;Biological Assay;carbapenem-resistant Enterobacteriaceae;chemical synthesis;Creatinine;Cryoelectron Microscopy;cytotoxicity;Derivation procedure;design;Development;Docking;drug clearance;Drug Kinetics;Elements;emerging antimicrobial resistance;Escherichia coli;Eukaryotic Cell;experimental study;FBXW7 gene;Feedback;Frequencies;Future;Goals;Gram-Negative Bacteria;Histopathology;Immune;Immunity;In Vitro;in vitro activity;in vivo;Infection;insight;Kidney;Laboratories;Length;Literature;Lysine;Maximum Tolerated Dose;Metabolic;Methyltransferase;Modeling;Modification;Molecular;mouse model;Multi-Drug Resistance;Mus;Mutation Analysis;Natural Products;Nevada;novel;novel therapeutics;Operon;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;pre-clinical;Productivity;Property;Protein Inhibition;Proteins;Pseudomonas aeruginosa;Resistance;Ribosomal RNA;Ribosomes;scaffold;Site;Structure;Structure-Activity Relationship;sugar;Synthesis Chemistry;Testing;Therapeutic;Therapeutic Effect;Thigh structure;Time;tissue culture;Toxic effect;Toxicology;Transferase;translation assay;Translations;Treatment Efficacy;Variant;Virulent;Work

PROJECT_TITLE: Use of De Novo Synthesis Approaches and Structure-guided Design to Optimize Therapeutic Properties of Streptothricin Class Antimicrobials

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(02)M]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Genetics;Hematology;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Sepsis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Sepsis is a common and life-threatening response to infection that commonly leads to severe injury to the lung, known as the acute respiratory distress syndrome (ARDS). We have identified a genetic variant in the gene for haptoglobin that predisposes sepsis patients to develop ARDS. This proposal will define the mechanisms of this increased risk of ARDS with the goal of developing new therapies to prevent ARDS.

PI_NAMEs: WARE, LORRAINE B (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Adhesions;African;African ancestry;Alleles;antimicrobial;antioxidant therapy;Ascorbic Acid;Bacteria;Blood Vessels;Cells;Cessation of life;Chronic Disease;Circulation;Clinical;Clinical Trials;Critical Illness;Data;Development;Diabetes Mellitus;Dose;Early identification;Early treatment;Endothelium;Enzymes;European;European ancestry;ex vivo perfusion;Exposure to;Functional disorder;Future;Genes;Genetic;genetic manipulation;genetic variant;Genetic Variation;Genotype;Glycocalyx;Glycosaminoglycans;Goals;Haptoglobins;Hemoglobin;Hemoglobin concentration result;heparanase;Homeostasis;HP gene;Human;Infection;Injury;insight;Lead;Leukocytes;Life;Link;Lung;lung injury;macrovascular disease;Mass Spectrum Analysis;Mediating;Mediator;Microvascular Permeability;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;new therapeutic target;novel;novel strategies;novel therapeutics;Organ;Orthologous Gene;Outcome;Oxidants;oxidation;oxidative damage;Oxidative Stress;Pathologic;Pathway interactions;Patients;Pattern;Permeability;Persons;pharmacologic;Phenotype;Plasma;polymicrobial sepsis;Population;Preparation;preservation;prevent;Prevention;Proteins;Publishing;Regional Perfusion;Reporting;Research;response;Risk;Sepsis;sepsis induced ARDS;septic patients;severe injury;Severities;Testing;therapeutic evaluation;trait;Translating;Translations;Up-Regulation;Variant;Vascular Endothelium

PROJECT_TITLE: Haptoglobin 2 variant and endothelial glycocalyx shedding in sepsis-induced ARDS

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative We are proposing to support investigators engaged in our 70 research projects focusing on high priority areas in the field of IDD conducted within an overarching framework of translational research. Combining the expertise of committed and well-established IDD investigators at the University of Washington with core and related University of Washington resources places our IDDRC in a position to make important advances in understanding the underlying causes of and providing effective treatments for individuals with IDD.

PI_NAMEs: JUUL, SANDRA E (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Animal Behavior;Animal Model;Animals;Area;autism spectrum disorder;Awareness;Basic Science;behavior test;Behavioral;behavioral phenotyping;Bioinformatics;Biological;Biological Models;Brain imaging;brain malformation;brain research;Cell model;central nervous system injury;Cerebellar malformation;Child;Clinical;Clinical Research;clinical translation;Clinical Trials;Collaborations;Communication;Communities;Consultations;design;developmental toxicology;Diagnosis;disability;Disability research;Disease;early childhood;Education;Educational Activities;effective therapy;Effectiveness;Electrophysiology (science);Environment;Epilepsy;Equipment;Evaluation;Faculty;Family;Fostering;functional genomics;Future;Genes;Genetic;Goals;Grant;Hearing problem;Human;Human Development;human genomics;human imaging;Human Subject Research;in vivo;in vivo imaging;Individual;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;interest;Intervention;Investigation;Leadership;Learning Disabilities;Magnetic Resonance;Maps;Mentors;Modality;Modeling;Nature;Newsletter;NMR Spectroscopy;nonhuman primate;Operative Surgical Procedures;Outcome Study;Periodicals;Pharmaceutical Preparations;Positioning Attribute;Positron-Emission Tomography;Precision therapeutics;prevent;programs;Research;research data dissemination;Research Design;Research Institute;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resources;Rodent Model;Scientist;Series;Services;Site;Study models;Subgroup;symposium;Technical Expertise;Techniques;Technology;Testing;translational framework;Translational Research;Universities;Washington;web site;Work


NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: GURALNICK, MICHAEL J (contact)

PROJECT_TERMS: Advocacy;Animal Behavior;Area;autism spectrum disorder;Award;Basic Science;Biological;brain behavior;Brain imaging;brain malformation;Career Choice;Central Nervous System Diseases;central nervous system injury;Clinic;Clinical;Clinical Services;clinical translation;Clinical Trials;Collaborations;Communities;community partnership;Department chair;design;Development;developmental toxicology;Diagnosis;early childhood;Education;Ensure;Epilepsy;Faculty;Feedback;Funding;Future;Genes;Genetic;Goals;Hearing problem;Individual;information gathering;innovation;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Interdisciplinary Study;Intervention;Knowledge;Leadership;Learning Disabilities;lectures;Longitudinal Studies;meetings;member;Mentors;Newsletter;organizational structure;outreach program;patient population;Patients;Pediatric Hospitals;Phase;pre-clinical;Prevention;programs;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Series;Services;Site;Source;Surveys;Training;Translational Research;Universities;Visit;Washington;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

PI_NAMEs: WEBB, SARA JANE (contact)

PROJECT_TERMS: Area;Behavior;Behavior assessment;behavior observation;Behavioral;behavioral phenotyping;biomedical informatics;Biometry;brain behavior;catalyst;Clinical;clinical database;clinical practice;Clinical Research;clinical translation;Clinical Trials;Code;Community Outreach;Consultations;data mining;Dedications;design;Development;Developmental Disabilities;Dimensions;disability;Disease;Dysmorphology;Education;education research;Electronic Health Record;Evaluation;experience;Face;Family;Foundations;gene discovery;Genes;Genotype;Goals;Head;Human;Human Development;Human Subject Research;Individual;Industry;industry partner;Infrastructure;innovation;Institution;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Laboratories;Measures;Methods;Modality;Molecular;Movement;Neurodevelopmental Disorder;novel diagnostics;Parents;Performance;Phase;Phenotype;Process;programs;recruit;Research;Research Personnel;research study;Research Support;Resources;Scientist;Services;Standardization;Study Subject;Subgroup;symposium;Therapeutic Intervention;tool;Training;translational framework;translational health science;Translational Research;Universities;Video Recording;visual tracking;working group

PROJECT_TITLE: Clinical Translational Core


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Synaptic signaling is based on a complex interplay between neurotransmitters, such as GABA and glutamate, and neuromodulators, such as neurotrophic growth factors. We propose here to identify the molecular mechanisms by which a neurotrophin receptor (TrkB) and a metabotropic glutamate receptor (mGluR5) are able to mutually regulate each other to drive a unique form of crosstalk-dependent synaptic plasticity.

PI_NAMEs: LEE, FRANCIS SANG YONG;LEVITZ, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;anti-depressive agents;antidepressant effect;Attention;Attenuated;Binding;Binding Proteins;Biological Assay;Biosensor;Brain;Brain-Derived Neurotrophic Factor;Calcium;Cells;Central Nervous System;Complex;Data;Dendrites;desensitization;Development;Electrophysiology (science);Event;extracellular;Family;Family member;fluorescence imaging;Fluoxetine;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic;genetic manipulation;Glutamates;Growth Factor;GTP-Binding Proteins;Guanine;Guanine Nucleotide Exchange Factors;Hippocampus;Ion Channel;Ketamine;Knockout Mice;Long-Term Depression;Long-Term Potentiation;Mediating;Mediator;metabotropic glutamate receptor 5;Metabotropic Glutamate Receptors;Molecular;Nerve Growth Factor Receptors;Nervous System Physiology;Neurodegenerative Disorders;Neuromodulator;neuronal circuitry;Neuronal Plasticity;Neurons;Neuropeptides;neuropsychiatric disorder;Neurotransmitters;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;optogenetics;Output;Pathway interactions;Pharmacology;Phosphotransferases;Physiological;postsynaptic;Property;Protein Secretion;receptor;Receptor Protein-Tyrosine Kinases;receptor-mediated signaling;response;Role;Series;Shapes;Signal Transduction;Slice;spatiotemporal;Synapses;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;synergism;System;Testing;Time;tool;trafficking;treatment strategy;Work

PROJECT_TITLE: Molecular and Synaptic Mechanisms of Neurotrophin-glutamate Crosstalk

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Disability Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: DOHERTY, DANIEL  (contact)

PROJECT_TERMS: Alleles;Animal Behavior;Animal Model;Antisense Oligonucleotides;Behavioral Assay;Brain;Brain imaging;brain malformation;C-terminal;Candidate Disease Gene;Cell model;Cerebellar malformation;Cerebellar vermis structure;Cerebellum;Cerebral cortex;Characteristics;Collaborations;craniofacial;cranium;Data;Development;Developmental Brain Malformation;Developmental Disabilities;differential expression;Disease;DNA Sequence;Dominant-Negative Mutation;Dysmorphology;Epilepsy;experience;Future;gain of function;gene discovery;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Heterozygote;High Prevalence;Histology;Human;human model;human stem cells;Individual;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Investigation;Magnetic Resonance Imaging;Methods;microCT;Microgyria;migration;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nerve stem cell;Neuronal Differentiation;Neuronal Migration Disorder;Neurons;Nonsense-Mediated Decay;novel;Parents;Pathway interactions;Patients;Phenotype;Proteins;Research Personnel;Research Project Grants;Research Project Summaries;RNA Sequence Analysis;Role;single cell sequencing;stem cell model;stem cells;Structure;Syndrome;Testing;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;Variant

PROJECT_TITLE: Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: Animal Model;Behavior assessment;Behavioral;Bioinformatics;Biological;Biological Assay;Biological Models;Blood;Brain imaging;Cell model;cell type;Chromatin Structure;clinical translation;cohort;Consent;Consultations;cost;Counseling;Data;design;Development;Diagnosis;diagnostic tool;differentiation protocol;Disease;disease model;Doctor of Philosophy;Enrollment;Ensure;Epigenetic Process;Evaluation;exome sequencing;experience;functional genomics;Funding;Future;Gene Chips;gene discovery;Genetic;genetic variant;genome editing;Genome engineering;genome sequencing;Genomics;Goals;human genomics;human subject;Image;improved;induced pluripotent stem cell;Infection;Injury;Institutional Review Boards;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Link;medical complication;Messenger RNA;metabolomics;Monitor;Mutation;Nervous System;novel;novel diagnostics;Organoids;Pathogenesis;Pathology;Patient Recruitments;Patients;pediatric department;Phenotype;Premature Birth;Prevention;Procedures;prognostic;programs;protein expression;Proteomics;protocol development;Recurrence;Research;Research Design;Research Personnel;Research Support;Resources;response;Risk;Saliva;sample collection;Services;single cell analysis;single cell genomics;single-cell RNA sequencing;Skin;stem cell model;targeted sequencing;targeted treatment;Technology;tool;Toxic Environmental Substances;Toxin;transcriptome sequencing;transcriptomics;Translating;translational goal;Urine;Validation;variant detection

PROJECT_TITLE: Genetics Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative To understand the mechanism underlying seizures associated with alcohol withdrawal, we propose to investigate the novel hypothesis that altered neuronal activity and connectivity of hippocampal newborn neurons underlie development of alcohol withdrawal seizures. Using state-of-the art methods, we will map neuronal and functional connectivity, as well as activity of neural circuits that are responsible for alcohol withdrawal seizures. Outcomes of this proposal will provide molecular, cellular, and neural circuitry mechanisms by which hippocampal newborn DGCs impact on local and global neural circuits that underlie alcohol withdrawal seizures.

PI_NAMEs: SUH, HOONKYO  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Alcohol abuse;Alcohol dependence;alcohol effect;alcohol exposure;alcohol response;Alcohol Withdrawal Seizures;Alcohol withdrawal syndrome;Anatomy;Brain;cell type;Cells;Chronic;Color;Dangerousness;Data;designer receptors exclusively activated by designer drugs;Development;differential expression;Epilepsy;Equilibrium;excitatory neuron;experimental study;Foundations;Generalized seizures;Genes;Genetic Epistasis;Goals;granule cell;hippocampal pyramidal neuron;Hippocampus;Hour;Hyperactivity;Image;Imaging Device;imaging modality;Induced Neurons;inhibitory neuron;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Mediating;Methods;Modality;Molecular;neural;neural circuit;neurogenesis;Neurons;Newborn Infant;newborn neuron;novel;novel therapeutic intervention;Outcome;Parvalbumins;Pathologic;Play;postsynaptic neurons;Predisposition;presynaptic;rabies viral tracing;Rabies virus;Recurrence;Relapse;Resolution;Role;Seizures;Series;Severities;Signal Transduction;single-cell RNA sequencing;Symptoms;Synapses;Syndrome;Testing;Time;Tonic - clonic seizures;transcriptome;transmission process;Vertebral column;Visualization;Wheat Germ Agglutinins

PROJECT_TITLE: Activity and connectivity of hippocampal newborn neurons underlie alcohol withdrawal-associated syndromes

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: 8. PROJECT NARRATIVE Preventive interventions for college student risky drinkers are well established, but the needs of emerging adult risky drinkers who live in disadvantaged communities and are not fulltime college students have been neglected, and they often have more limited access to rewarding opportunities, activities, and adult roles that present alternatives to heavy drinking. Guided by behavioral economics, this randomized controlled trial will address their needs by evaluating an evidence-based behavioral intervention aimed at increasing future orientation and engagement in pro-social alternatives to drinking and will be delivered using a peer- driven sampling method and digital platform well suited for accessing emerging adult social networks. The study will be the first to test a web-based alcohol reduction intervention focused on behavioral economic principles and has high potential for reach and scalability with under-served community risk groups.

PI_NAMEs: TUCKER, JALIE A. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Acute;addiction;Address;Adult;Age;Alcohol consumption;alcohol demand;alcohol free;alcohol intervention;alcohol involvement;alcohol related consequences;alcohol risk reduction;Alcohols;Attenuated;Behavior;behavior change;behavior test;Behavior Therapy;Behavioral;behavioral economics;brief motivational intervention;brief screening;Cellular Phone;Chronic Disease;Clinical Treatment;Cluster randomized trial;cohesion;college;Communication;Communities;comparison intervention;computerized;cost effectiveness;Coupled;critical developmental period;design;Diffusion;digital;digital delivery;digital intervention;digital platform;discounting;drinking;Economic Models;Economics;Education;Effectiveness;Ego;Electronic Mail;Elements;emerging adult;Employment;Environment;environmental enrichment for laboratory animals;Evaluation;evidence base;Female;follow up assessment;Fostering;Future;Generations;Goals;Health;Heavy Drinking;high risk drinking;human old age (65+);Individual;Intervention;intervention effect;Length;Life;Life Style;Marriage;Mediating;Mediator;member;Meta-Analysis;Methods;Motivation;neglect;neighborhood disadvantage;non-drug;Online Systems;Outcome;outcome prediction;Participant;Pathway Analysis;peer;peer influence;peer networks;Persons;Pharmaceutical Preparations;post intervention;preventive intervention;Privacy;Psychological reinforcement;public health intervention;Randomized;Randomized, Controlled Trials;recruit;Research;Respondent;Rewards;Risk;Role;Sampling;Schedule;screening and brief intervention;sobriety;social;Social Network;social relationships;Source;substance misuse;substance misuse prevention;substance use;Target Populations;technology intervention;Testing;theories;Time;tool;Translating;Treatment Efficacy;underserved community;university student;web platform;web-based intervention

PROJECT_TITLE: Digital Motivational Behavioral Economic Intervention to Reduce Risky Drinking Among Community-Dwelling Emerging Adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

PI_NAMEs: MARAVILLA, KENNETH R (contact)

PROJECT_TERMS: Animal Behavior;Animals;autism spectrum disorder;Basic Science;Behavioral;Biological Markers;Brain imaging;brain malformation;clinical center;clinical translation;cluster computing;Collaborations;Communities;complex data;computer generated;Computer software;Computer Workstations;Consultations;cost;Data;Data Analyses;Data Set;Databases;design;Development;Diagnosis;Diagnostic Imaging;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Early Diagnosis;Educational workshop;Electroencephalography;Electrophysiology (science);Ensure;Equipment;Evaluation;Event-Related Potentials;Experimental Designs;experimental study;Foundations;Functional Magnetic Resonance Imaging;gene therapy;Genetic;Goals;Health Insurance Portability and Accountability Act;High Performance Computing;Human;Image;Image Analysis;image processing;imaging facilities;imaging modality;imaging scientist;Imaging technology;in vivo;Individual;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Laboratory Research;Learning Disabilities;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetoencephalography;Metadata;Methodology;Methods;Mission;Modality;Muscular Dystrophies;Neurodevelopmental Disorder;neuroimaging;Neurosciences Research;novel;Perfusion;Perinatal Brain Injury;Phase;Physiological;Positron-Emission Tomography;Postdoctoral Fellow;Premature Birth;Prevention;Procedures;programs;Radiology Specialty;Reproducibility;Research;Research Personnel;Research Project Grants;research study;Research Support;Resources;Retrieval;Science;Secure;source localization;Spectrum Analysis;Statistical Data Interpretation;Stimulus;Students;Techniques;technology/technique;Testing;tool;Training;translational goal;Translational Research;Universities;Washington;Work

PROJECT_TITLE: Brain Imaging Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: NARRATIVE. Most Veterans are diagnosed with prostate cancer when the disease is confined to the prostate and amenable to cure. However, a significant proportion of localized tumors display aggressive features associated with a high risk of recurrence following definitive treatment (e.g. surgery or radiation). Our ability to predict which patients with high-risk prostate cancer will develop lethal metastasis is limited. We will leverage the VA healthcare system and assemble a massive dataset of digital images from diagnostic prostate biopsies and magnetic resonance imaging linked to standard clinico-pathologic factors and social determinants of health variables. Application of artificial intelligence (AI) approaches and integration of digital biomarkers with other variables will yield a “superclassifier” to quantify the likelihood of metastasis-free survival and determine treatment intensification interventions to reduce metastasis.

PI_NAMEs: GARRAWAY, ISLA PEARL;KNUDSEN, BEATRICE S;MADABHUSHI, ANANT ;NICKOLS, NICHOLAS GEORGE;RETTIG, MATTHEW B (contact)

PROJECT_TERMS: Algorithms;Artificial Intelligence;artificial intelligence algorithm;biobank;Biological Markers;cancer care;Categories;Cessation of life;Clinic;Clinical;Clinical Data;Clinical Management;Clinical Trials;Collection;Complex;Computer Vision Systems;convolutional neural network;cost;Data;Data Collection;data repository;data resource;Data Set;Data Sources;data warehouse;Databases;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Digital biomarker;digital imaging;digital pathology;Digital Radiography;digital repositories;Disease;Disease remission;Extramural Activities;Eye;feature selection;FOLH1 gene;follow-up;Future;Genomics;Goals;Guidelines;health data;Healthcare Systems;Hematoxylin and Eosin Staining Method;high risk;Histopathology;Human;Image;improved;improved outcome;Individual;Information Systems;Infrastructure;Integrated Health Care Systems;Intervention;Knowledge;Link;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Methods;military veteran;Modeling;Molecular;multidimensional data;multimodal data;multiple omics;National Comprehensive Cancer Network;Needle biopsy procedure;Neoplasm Metastasis;novel;Operative Surgical Procedures;Outcome;outcome prediction;Pathologic;Pathology;Patients;Pattern;Positron-Emission Tomography;precision oncology;predictive modeling;prognostic;prognostic model;prognostication;Prostate;prostate biopsy;prostate cancer risk;Protocols documentation;Radiation;radiological imaging;radiomics;Recurrence;repository;Research Personnel;Risk;Science;Skin Carcinoma;Slide;social health determinants;Staging;Stains;Statistical Data Interpretation;Stratification;Structure;success;Testing;Tissues;tool;training data;transcriptomics;treatment strategy;tumor;United States Department of Veterans Affairs;Validation;Veterans;Veterans Health Administration;Visual

PROJECT_TITLE: Predicting Metastatic Progression of High Risk Localized Prostate Cancer


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PI_NAMEs: BURBACHER, THOMAS M (contact)

PROJECT_TERMS: Animal Behavior;animal care;animal imaging;Animal Model;Area;Behavior;Behavior assessment;behavior test;Behavioral Research;Biological Models;Brain;Brain imaging;brain research;Budgets;Calcium Signaling;Characteristics;Chemicals;Child;Child Development;clinical application;clinical development;clinical translation;Cognitive;Consultations;cost;cost effective;cost estimate;Counseling;Data;data management;Development;education research;Environmental Exposure;Equipment;Experimental Designs;Fiber;functional outcomes;gene editing technology;Gene Modified;Genes;Genetic;Grant;in vivo;Infrastructure;innovation;insight;Intellectual and Developmental Disabilities Research Centers;Intellectual functioning disability;Intervention;Knowledge;Laboratories;Maps;Methods;Modeling;Motor;neural;Neurosciences;nonhuman primate;novel;Operative Surgical Procedures;optogenetics;Pharmaceutical Preparations;Photometry;prevent;Primates;programs;Protocols documentation;Publications;Rattus;Regulation;Research;Research Institute;Research Personnel;Research Project Grants;Research Training;Resources;response;Rodent;Rodent Model;Sensory;Services;social;Students;Study models;Techniques;Technology;Testing;tool;Training;translational goal;Translational Research;Universities;Update;Washington;Work

PROJECT_TITLE: Animal Behavior Core


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Foodborne Illness;Genetics;Social Determinants of Health

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: ST. MARY'S UNIVERSITY

PHR: Project Narrative Plastic and chemical pollutants are pervasive in the environment and an emerging human health concern. The proposed research is relevant to public health because it will establish a novel model system to rigorously and reproducibly study exposure to nanoplastic and environmentally relevant chemical pollutant mixtures. Once such strategies are developed, there is a potential for significant advancement in understanding the cellular and molecular basis of combined nanoplastic-chemical mixture impact on physiology and thus possible risks to human health.

PI_NAMEs: HARR, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: absorption;Affect;Air;Animal Model;Animals;Area;Behavior;bioaccumulation;Biological;Biological Models;biological systems;Blood;Caenorhabditis elegans;Chemical Exposure;Chemicals;Chromosome Structures;Consumption;Data;Defect;delivery vehicle;Development;Developmental Delay Disorders;Dibutyl Phthalate;DNA Damage;DNA Repair;Embryo;Embryonic Induction;Environment;environmental chemical;environmental chemical exposure;Environmental Health;environmental toxicology;experience;Experimental Models;experimental study;Exposure to;Food;Frequencies;Genes;genome integrity;Genome Stability;genotoxicity;Germ Lines;Goals;Health;High Pressure Liquid Chromatography;Human;human tissue;Impairment;in vivo;Individual;Ingestion;innovation;Insecticides;Investigation;Knowledge;Laboratories;Libraries;Location;Mammalian Cell;Mammals;Mass Spectrum Analysis;Metabolism;meter;Methods;model organism;Molecular;Motility;Muscle;Mutation;novel;Outcome;particle;Pathologic;Pathway interactions;Permethrin;Pesticides;Phase;Phenotype;phthalates;Physiological;Physiology;Placenta;Plasticizers;Plastics;pollutant;Polystyrenes;prevent;Productivity;programs;Protocols documentation;Public Health;Reporter;Reproducibility;Research;Risk;shear stress;Source;Sterility;Students;System;Testing;Time;Tissues;Toxic effect;Toxicology;Toxin;Training;undergraduate research;Water;Whole Organism

PROJECT_TITLE: A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Genetics;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_DEPT: PHARMACOLOGY

PHR: Project Narrative. This proposal will investigate the impact of adolescent ethanol exposure on adult neurocircuitry and behaviors that include the most significant known risk factors for developing an alcohol use disorder.

PI_NAMEs: CREWS, FULTON T (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Acetylcholine;Acute;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;adolescent brain development;Adolescent Development;Adult;Affect;Alcohol consumption;alcohol response;alcohol sensitivity;alcohol use disorder;Anti-Anxiety Agents;Anti-Inflammatory Agents;ATAC-seq;Autopsy;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;behavioral response;Brain;Brain region;cholinergic;cholinergic neuron;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cognition;cognitive function;Collaborations;Disinhibition;drinking;Enhancers;Epigenetic Process;epigenetic silencing;Ethanol;Exercise;Female;flexibility;FOS gene;Galantamine;gene induction;Genes;Hippocampus;Histone Deacetylase Inhibitor;HMGB1 gene;Human;Immediate-Early Genes;Impaired cognition;Indomethacin;Inflammatory;inhibitor;Intoxication;Link;longitudinal design;Magnetic Resonance Imaging;male;Mediating;Messenger RNA;Molecular;Motor;natural hypothermia;Nerve Degeneration;nerve stem cell;neural circuit;neurogenesis;Neuroglia;Neuroimmune;Neurons;Pathology;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;preference;prevent;Promoter Regions;Prosencephalon;receptor;receptor for advanced glycation endproducts;response;Risk Factors;Role;sedative;Signal Transduction;Synaptic plasticity;Testing;TLR4 gene

PROJECT_TITLE: 5/8 NADIA U01 Effects of Adolescent Alcohol on adult brain Neurocircuitry


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE  Effective treatments of many neurological diseases rely on the understanding of the functional networks in the deep brain, which presents technical challenges in terms of neural interface devices. Our proposed studies aim to address these challenges by developing a spatially expandable, multifunctional fiber-based probe for large volume, deep brain interfacing. These studies will have the potential to provide new insights as well as new therapeutic strategies for various neurological diseases, and provide a powerful tool for advancing the fundamental study of the microcircuitry and functional network in both animal and human brains.

PI_NAMEs: JIA, XIAOTING  (contact);SONTHEIMER, HARALD W

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Animals;Biochemical;biomaterial compatibility;Biomechanics;Brain;Brain region;brain tissue;Chemicals;Chronic;Clinical;clinically relevant;design;Detection;Development;Devices;Diameter;Disease;Distant;Drug Delivery Systems;Drug Regulations;effective therapy;electric impedance;Electrodes;Electroencephalography;Electrophysiology (science);Elements;Engineering;Epilepsy;experimental study;extracellular;fabrication;Fiber;Future;Goals;Histocompatibility;Histology;Human;Image;Implant;in vivo;insight;Intervention;Lasers;local drug delivery;Maps;Mechanics;Mental disorders;meter;Methods;millimeter;minimally invasive;mouse model;Mus;Nervous System Disorder;neural;neuropsychiatry;novel;novel therapeutic intervention;Operative Surgical Procedures;Optics;optogenetics;Parkinson Disease;patient population;Patients;Penetration;Performance;Persons;Pharmaceutical Preparations;Pharmacological Treatment;Polymers;Regulation;Research;Resolution;response;Saline;Sampling;Seizures;side effect;Site;Slice;spatiotemporal;Specificity;Spectrum Analysis;success;Surface;Technology;temporal measurement;Testing;Time;Tissues;tool;Transgenic Mice;Trephine hole;Virus;Work

PROJECT_TITLE: 3D multifunctional deep brain interface for seizure detection and intervention

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: DENVER

ORG_NAME: NATIONAL ENVIRONMENTAL HEALTH ASSOCIATION

ORG_STATE: CO

PHR: National Environmental Health Association (NEHA) PROPOSAL FOR FUNDING OPPORTUNITY ANNOUNCEMENT RFA-FD-22-008 Project Narrative This proposal builds on the foundational principles of food safety, focusing on preventative measures at the retail level that will lead to higher rates of compliance with current food safety requirements and standards, thereby reducing foodborne illness. This collaborative approach with other retail food safety associations leverages resources and collective expertise to 1) identify gaps in existing support for the retail food safety workforce; 2) highlight best practices, tools, and resources; and 3) develop new, modern, and accessible materials. Together, we will advance and strengthen the retail food safety workforce and empower industry and regulatory members to improve existing practices and reduce foodborne illnesses.

PI_NAMEs: DYJACK, DAVID T (contact);WILDEY, LAURA M

PROGRAM_OFFICER_NAME: NIESEN, MARIBETH

PROJECT_TITLE: Innovative Approaches That Collaboratively Advance Retail Food Safety Initiatives to Reduce the Occurrence of Foodborne Illness


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Quantitative assessment of mitral valvular regurgitation flow plays is critical to risk-stratify patients but is considered highly challenging due to its complex hemodynamics. We aim to develop a robust 3D flow quantification framework by combining novel dual-venc 4D flow MRI approach and multi-task deep learning.

PI_NAMEs: LEE, JEESOO  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;4D MRI;Acceleration;accurate diagnostics;Address;Affect;Agreement;aortic valve;Area;Blood flow;Blood Flow Velocity;Cardiac;cardiac magnetic resonance imaging;Cessation of life;Classification;Clinical;clinical application;clinical translation;Compensation;Complex;Coupled;Data;Data Set;deep learning;design;Detection;detection method;Disease;Echocardiography;Enrollment;Evaluation;healthy volunteer;Heart;Heart failure;hemodynamics;high risk;Image;imaging modality;improved;In Vitro;in vivo;innovation;learning network;Left atrial structure;Lesion;Magnetic Resonance Imaging;Manuals;Measurement;Measures;Methods;Mitral Valve Insufficiency;Modeling;Morphology;multitask;Nature;Noise;novel;Output;patient stratification;Patients;Phase;Physiologic pulse;Play;Population;Process;Pulmonary valve structure;Reporting;Reproducibility;research clinical testing;Resolution;Risk;risk stratification;Role;Scanning;Scheme;Severities;Severity of illness;Shunt Device;Site;Stroke Volume;success;Techniques;Testing;three-dimensional visualization;Time;tool;Training;translational approach;treatment planning;Tricuspid valve structure;Uncertainty;Visualization;Work

PROJECT_TITLE: Mitral Regurgitation Quantification Using Dual-venc 4D flow MRI and Deep learning

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Hypertension;Kidney Disease;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Established health disparities for hypertension and CKD exist for African Americans with regard to both prevention and treatment of these disorders. The proposed work will create novel screening tools that may help better prevent and treat these diseases using genetic markers that can be measured in the clinic.

PI_NAMEs: IRVIN, MARGUERITE R (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Adrenergic beta-Antagonists;African American population;African ancestry;Agreement;American;Ancillary Study;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Anti-Hypertensive Agents;Blood Pressure;Calcium Channel Blockers;Cardiorenal syndrome;Cessation of life;Chlorthalidone;Chronic Kidney Failure;Clinic;cohort;Coronary heart disease;Data;Data Set;Disease;Disparity;Diuretics;End stage renal failure;Environmental Risk Factor;European;Genetic;Genetic Markers;genetic risk factor;genome wide association study;Genomics;Genotype;Health;health disparity;Hypertension;improved;International;Kidney Diseases;Lipids;Lisinopril;Measures;Myocardial Infarction;National Heart, Lung, and Blood Institute;novel;Outcome;Participant;personalized medicine;Pharmacogenetics;Pharmacogenomics;Phenotype;polygenic risk score;Population;prevent;Prevention;programs;racial population;Randomized;Research;Resources;response;risk prediction;Risk Reduction;Sample Size;Screening procedure;Stroke;Testing;trait;Trans-Omics for Precision Medicine;Translating;treatment effect;treatment response;validation studies;Variant;whole genome;Work

PROJECT_TITLE: Cardiorenal Genomics for Risk Prediction in African Descent Populations


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: OTHER PROJECT INFORMATION – Project Narrative The research themes of the Center deal with some of the nation’s biggest health challenges and opportunities. In each of these areas, the potential for scientific findings that improve health outcomes is significant. The themes of Center research are: (1) health trends and inequalities, (2) data analytics, information technology and health care decision-making, (3) the economics of Alzheimer’s disease and related dementias, (4) the dynamics of the health care ecosystem, and (5) medical innovation and the value of health care.

PI_NAMEs: CUTLER, DAVID M (contact);JOYNT MADDOX, KAREN ELLEN

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Aging;aging related;Alzheimer's disease related dementia;Area;Attention;base;Collaborations;Collection;Communication;Communities;Data Analytics;data resource;Databases;Decision Making;Development;Dimensions;Discipline;Economics;Ecosystem;Environment;Event;Fostering;Foundations;Funding;Grant;Health;health inequalities;Health trends;Healthcare;human old age (65+);improved;Individual;Information Technology;Infrastructure;innovation;Intervention;Investigation;Lead;Leadership;Libraries;Maintenance;Medical;meetings;Methodology;Newsletter;operation;Outcome;Paper;Persons;Pilot Projects;Policy Developments;Preparation;Productivity;Program Development;recruit;Reporting;Research;Research Activity;research and development;research data dissemination;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Role;Science;Series;social media;Structure;symposium;two-dimensional;Universities;web site;Work

PROJECT_TITLE: NBER Center for Aging and Health Research


NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: CASE, ANNE  (contact)

PROJECT_TERMS: Aging;aging related;Alzheimer's Disease;Attention;central database;Collaborations;Collection;Communities;Creativeness;Data;Data Analytics;Data Collection;data library;data management;data resource;Database Management Systems;Databases;Deaths of despair;Decision Making;Development;Economics;Educational workshop;Environment;Evolution;Funding;Future;Geography;Glues;Grant;Group Meetings;Health;health economics;health inequalities;Healthcare;Human Resources;improved;Infrastructure;Investigation;Judgment;Leadership;Libraries;Machine Learning;Magnetism;Medicare claim;meetings;operation;opioid use;Pain;Persons;Pilot Projects;Preparation;Process;Productivity;program dissemination;programs;Publications;Records;recruit;Reporting;Research;Research Activity;research and development;research data dissemination;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Research Training;Resource Development;Resources;Role;Structure;Sum;Supervision;symposium;Training;Training Programs;Work;working group

PROJECT_TITLE: Core A. Administrative and Research Support Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Services;Neurodegenerative;Neurosciences;Prevention

PROJECT_TERMS: Aging;Alzheimer's Disease;Alzheimer's disease risk;Ambulatory Surgical Procedures;Antipsychotic Agents;Area;Behavior Control;Behavioral Symptoms;beneficiary;Caring;Clinic;Cognitive;cognitive testing;community partners;Companions;Data;data resource;Dementia;Development;Diagnosis;Dimensions;Discipline;Disease;Documentation;Economics;Ecosystem;Effectiveness;Elderly;Environmental Risk Factor;epidemiology study;Event;expectation;feasibility testing;Genetic;genetic predictors;Genetic Risk;genetic risk factor;Goals;Health;health care delivery;Health Status;Health Surveys;Healthcare;improved;Incentives;Independent Living;Individual;innovation;Intervention;Measures;Medicare;Methods;mild cognitive impairment;nursing home length of stay;Nursing Homes;off-label use;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Performance;Persons;Pilot Projects;Policy Developments;polygenic risk score;population based;Program Development;programs;Provider;Randomized, Controlled Trials;Reporting;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Role;social influence;social science research;stem;support network;Testing;timeline;urgent care;volunteer;wellness visit;Work

PROJECT_TITLE: Core B. Program Development (Pilot) Core