NIH_SPENDING_CATS: Cancer;Clinical Research;Prostate Cancer;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Given that prostate cancer kills more than 350,000 men per year worldwide, there is an urgent need for development of more effective therapies for this disease. Bipolar androgen therapy (BAT) is an ideal backbone on which to layer additional therapies because it is associated with minimal biological and financial toxicity. The proposed research will explore metabolic vulnerabilities induced by BAT to identify metabolic synthetic lethal drug combinations that might improve outcomes for patients with prostate cancer.

PI_NAMEs: SENA, LAURA A. (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: androgen independent prostate cancer;Androgen Receptor;Androgen Therapy;Androgens;Area;Automobile Driving;Benign;Biological;cancer cell;cancer therapy;career development;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Data;Dependence;Development;Disease;DL-alpha-Difluoromethylornithine;Dose;Down-Regulation;Drug Combinations;effective therapy;efficacy evaluation;Enzymes;experience;Exposure to;financial toxicity;Genes;Genetic Screening;Goals;Growth;Hormonal;Immune Tolerance;improved;improved outcome;In Vitro;in vivo;instructor;Malignant - descriptor;Malignant neoplasm of prostate;medical schools;men;Mentors;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;novel therapeutics;nucleotide metabolism;Nucleotide Synthesis Inhibition;Oncology;Ornithine Decarboxylase;Pathway interactions;patient derived xenograft model;patient population;patient subsets;Patient-Focused Outcomes;Patients;Phase;Physicians;Polyamine Synthesis Inhibition;Polyamines;Program Development;programs;Prostate;prostate cancer cell line;Prostate Cancer therapy;Purine Nucleotides;Pyrimidine Nucleotides;Quality of life;Receptor Signaling;Research;research and development;Resistance;response;Scientist;Serum;Signal Transduction;skills;standard of care;targeted treatment;Testing;Testosterone;Therapeutic;therapeutic target;therapy development;therapy resistant;Tissues;Training;translational physician;Treatment Efficacy;tumor;tumor metabolism;Universities;Up-Regulation;Vertebral column

PROJECT_TITLE: Synthetic lethal metabolic drug combinations for castration-resistant prostate cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Mental Health;Pediatric;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health

ORG_CITY: MOUNT PLEASANT

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Parent mental health and caregiver self-efficacy can be significantly and negatively impacted by the trauma associated with a child’s PICU admission, affecting parents’ ability to help their child optimally recover. This research seeks to build a feasible intervention that will help PICU parents gain skills that help reduce immediate distress, which in turn, could reduce future parent PTSS and enhance caregiver self-efficacy. This is expected to have a positive impact by improving parents’ ability to support their child’s recovery and is relevant to the NICHD’s mission to lead research that enhances the lives of children and adolescents.

PI_NAMEs: YAGIELA, LAUREN  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Academy;Address;Adherence;Admission activity;Adolescent;Adoption;Adult;Affect;African American;Award;Behavior Therapy;career;Caregivers;caucasian American;Child;Child Health;Childhood;Collaborations;Communication;Competence;Conduct Clinical Trials;coping;cost;Critical Care;Critically ill children;Data;design;Distress;Education;Educational Curriculum;Educational process of instructing;Effectiveness;efficacious intervention;efficacy testing;eHealth;emotion regulation;empowerment;Event;evidence base;Evidence based intervention;Exercise;experience;Failure;feasibility testing;feasibility trial;Focus Groups;Foundations;Funding;Future;Gender;Goals;Health Personnel;implementation barriers;implementation determinants;improved;improved outcome;Intervention;intervention delivery;intervention refinement;Interview;Lead;Learning;Life;Maintenance;Manuals;Measures;Medical;Medicine;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Methods;Mission;Modeling;Morbidity - disease rate;National Institute of Child Health and Human Development;Outcome;parental role;parenting intervention;Parents;Participant;Pediatric Intensive Care Units;Perception;Phase;physical conditioning;post-traumatic symptoms;Program Development;psychosocial;psychosocial resources;Race;racial diversity;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recovery;Research;Research Personnel;Resources;response;Risk;Role playing therapy;Safety;Scientist;Self Efficacy;skills;Social support;Standardization;Stress and Coping;Structure;symposium;systematic review;Testing;theories;tool;Training;Trauma;Work

PROJECT_TITLE: Building and testing feasibility of EMPOWER, a skill-based psychosocial intervention for parents of critically ill children

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Cancer;Radiation Oncology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Approximately 50% of all cancer patients will receive radiation therapy during the course of their illness; unfortunately, bone is often in the direct path of exposure during treatment. As disease free survival continues to improve, bone damage from radiation which includes increased risk for fracture has become a prominent clinical issue. In this proposal we seek to aid patients by identifying unique molecular mechanisms and pharmacological agents which can be used to protect bone after exposure to radiation.

PI_NAMEs: WU, COLLEEN  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Ablation;absorption;Adipocytes;Adipose tissue;Anatomy;bHLH-PAS factor HLF;Biology;bone;Bone Development;bone loss;Bone Marrow;cancer cell;Cancer Patient;cancer therapy;Cell Culture Techniques;Cell Physiology;Cell Survival;cell type;Cells;cellular targeting;Clinical;Combined Modality Therapy;Data;defined contribution;Disease-Free Survival;DNA Damage;efficacy evaluation;Encapsulated;experimental study;Exposure to;FDA approved;Fracture;fracture risk;Genetic;Genetically Engineered Mouse;Goals;head-to-head comparison;Homeostasis;Hypoxia;Hypoxia Inducible Factor;Impairment;improved;In Vitro;inhibitor;Ionizing radiation;Knowledge;Label;lipid biosynthesis;Location;Malignant Neoplasms;Marrow;Mesenchymal Stem Cells;Minerals;Modality;Molecular;Molecular Target;mouse model;Mus;Mutant Strains Mice;nanocarrier;novel;Osteoblasts;Oxygen;Pathology;patient population;Patients;pharmacologic;Phase II/III Clinical Trial;Phenotype;Population;prevent;Radiation;Radiation exposure;Radiation induced damage;radiation mitigation;Radiation Protection;Radiation therapy;Radiation-Protective Agents;radioprotected;Reporter;response;Role;Signal Pathway;Signal Transduction;Site;Stimulus;Stress;targeted delivery;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Tomatoes;transcription factor;Treatment Efficacy;Treatment Protocols;tumor

PROJECT_TITLE: Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Dietary Supplements;Microbiome;Nutrition

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PHYSICS

ORG_NAME: WAKE FOREST UNIVERSITY

PHR: Project Narrative Oral microbiota are thought to play a significant role in determining the efficacy of therapeutic interventions using dietary nitrate. However, many individuals do not respond well to these interventions which we hypothesize is due to poor oral microbiotic conversion of nitrate to nitrite which is then converted to the important signaling molecule nitric oxide. This proposal aims at developing a probiotic that enhances oral conversion of nitrate to nitrite to improve interventions based in use of dietary nitrate and to understand the role of the oral bacteria in these interventions.

PI_NAMEs: KIM-SHAPIRO, DANIEL B (contact);YADAV, HARIOM

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adherence;Anemia;Animal Model;Anions;Antibiotic Resistance;Atherosclerosis;Back;Bacteria;base;Biological Assay;Biological Availability;Blood;candidate identification;Cell Line;Cells;Clinical;Clinical Research;Clinical Trials;cohort;Congestive Heart Failure;Control Animal;culture plates;Data;design;Development;Diabetes Mellitus;dietary nitrate;Disease;efficacy evaluation;Epithelium;exercise capacity;Genomics;Goals;Heart failure;Hemolytic Anemia;high throughput screening;Homeostasis;Human;human disease;Hypertension;improved;Individual;innovation;Intake;Intervention;Lead;Link;Malaria;Methods;Microbial Biofilms;microbiome;microbiome composition;Molecular;monolayer;mouse model;Nerve Degeneration;Nitrates;Nitric Oxide;Nitrites;novel;Nutrient;Obesity;Oral;Oral Administration;oral bacteria;Oral cavity;Oral Characters;oral microbial community;oral microbiome;Oral mucous membrane structure;Organ;Outcome;Pathogenicity;Pathology;Patients;Phase;Physiological;Physiology;Pilot Projects;Plasma;Play;Probiotics;Reporting;Role;Route;Safety;Saliva;Salivary Glands;screening;Signaling Molecule;Source;System;Testing;Therapeutic Intervention;Tissues;Tongue;Transfusion;translational applications;virulence gene

PROJECT_TITLE: Identification of bacterial strains for development of an oral probiotic aimed at increasing nitric oxide bioavailability

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Veteran suicide rates have remained elevated compared with the general population over the past 20 years. The Veterans Health Administration has national care guidelines recommending an enhanced care package (e.g., increasing outpatient mental health visits) after a Veteran engages in self-directed violence. Adherence to each care component is considered a marker of care quality for suicide risk (i.e., suicide-related care quality). Recent studies find care components are not provided equitably to all Veterans. As the extant literature shows Black, Indigenous, and People of Color (BIPOC) Veterans consistently receive poorer quality mental health care than white Veterans, they may also experience poorer suicide-related care. However, no research to date has examined suicide-related care for BIPOC Veterans. The current proposal seeks to evaluate suicide-related care quality among BIPOC Veterans using a concurrent, mixed-methods triangulation design to inform future intervention development and improve suicide-related care quality for all Veterans.

PI_NAMEs: CHEN, JASON I (contact)

PROJECT_TERMS: Address;Adherence;Affect;Age;Area;Belief;Black, Indigenous, People of Color;burnout;Caring;Characteristics;Clinical;Cognitive;comorbidity;Data;data repository;Data Sources;data warehouse;Databases;demographics;design;Diagnosis;Discrimination;enhanced care;Ensure;Equation;Equity;ethnic difference;ethnic diversity;ethnic identity;Evaluation;experience;Frequencies;Future;Gender;gender difference;Gender Identity;General Population;Guidelines;Health;health care quality;health disparity;health equity;Healthcare Systems;high risk;improved;innovation;inpatient psychiatric treatment;Inpatients;Intervention;Interview;Light;Link;Literature;Logistics;Measures;Medical Records;Mental Health;Mental Health Services;Methodology;Methods;Modeling;mortality;Outcome;Outpatients;patient population;Patients;people of color;Population Characteristics;Post-Traumatic Stress Disorders;prevent;prevention service;Process;Provider;provider factors;Quality Indicator;Quality of Care;Race;racial difference;racial identity;Recommendation;Recording of previous events;Recovery;Research;Risk;Risk Factors;Safety;Sampling;Self Direction;social;sociodemographics;Strategic Planning;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;System;therapy development;Veterans;Veterans Health Administration;Violence;Visit

PROJECT_TITLE: Serving All Who Have Served: Enhancing Suicide-Related Care Quality for Black, Indigenous, and People of Color Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Effective muscle tissue repair requires a coordinated series of state transitions during muscle repair. Understanding how coordination is achieved is critical to understand tissue regeneration in disease and aging. We have developed an exciting and novel project that will identify and characterize an unexplored role of P16Ink4a in healthy replicating muscle stem cells.

PI_NAMEs: FEELEY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Adhesions;Adult;adult stem cell;Aging;Atomic Force Microscopy;Behavior;Biomechanics;Biomedical Engineering;CDKN2A gene;Cell Adhesion;cell motility;Cell Physiology;Cells;Complex;Cytoskeleton;Data;Degenerative Disorder;Disease;Environment;extracellular;Extracellular Matrix;Feedback;Fibronectins;Genetic;genetic approach;Goals;Heterogeneity;Image;In Vitro;in vivo;insight;Integrins;Knock-out;Malignant Neoplasms;Measures;Mechanics;mechanotransduction;Mediating;migration;Molecular;Motility;Mus;Muscle;muscle progenitor cell;muscle repair;Muscle satellite cell;Myoblasts;novel;pharmacologic;Phenotype;Play;Process;Proliferating;Property;Publishing;receptor;regenerative;Regenerative capacity;Regulation;Reporter;Reporting;response;response to injury;Role;Sampling;self-renewal;senescence;Series;Signal Transduction;Skeletal Muscle;stem cell function;stem cells;Testing;Time;tissue regeneration;tissue repair;Tissues;Traction Force Microscopy;transmission process;Trauma;Tumor Suppressor Proteins;Work

PROJECT_TITLE: The role of P16Ink4a in adult skeletal muscle stem cells


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TUCSON

ORG_NAME: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: This study addresses a critical gap in quality of care for Veterans with heart failure (HF). Only 1/3 or fewer eligible Veterans are receiving SGLT2 inhibitors and mineralocorticoid receptor antagonists, both medications that save lives and prevents HF hospitalizations. We will combine insights from behavioral science and quality improvement science to create two types of ‘nudges’ – informational alerts and peer comparison feedback - to increase prescribing of these medications. We will compare the effect of these two nudge strategies alone and in combination compared to usual care. This project will develop simple, scalable, and low-cost strategies to improve the health of Veterans with HF.

PI_NAMEs: DEV, SANDESH  (contact)

PROJECT_TERMS: Academic Detailing;Address;Adoption;antagonist;arm;Behavior;behavior influence;Behavior Therapy;Behavioral;Behavioral Sciences;Cardiology;Cardiovascular system;Caring;Cessation of life;Clinical;Cognitive;comparative effectiveness;compare effectiveness;Control Groups;cost;data resource;Decision Making;design;Discipline;Drug Prescriptions;Effectiveness;effectiveness testing;Electronic Health Record;Eligibility Determination;Ensure;Environment;evidence base;Evidence based practice;experience;Feedback;Focus Groups;formative assessment;Glucose Transporter;Guidelines;Health;Healthcare;Heart failure;Heart Rate;Hospitalization;Hybrids;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;Informatics;Infrastructure;inhibitor;innovation;insight;Intervention;Interview;Investigation;Knowledge;Literature;meetings;Methodology;Mineralocorticoid Receptor;mortality;multi-component intervention;novel;Outcome;Patients;peer;Periodicals;Pharmaceutical Preparations;Pilot Projects;Practical Robust Implementation and Sustainability Model;Practice Guidelines;prescription opioid;prevent;prototype;provider behavior;Psychology;Quality of Care;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;receptor;Recommendation;Reporting;Research;Resources;Safety;Science;social norm;Sodium;Testing;theories;treatment as usual;Treatment Failure;Veterans;Work

PROJECT_TITLE: Preliminary Implementation of an Informational Nudge to Improve Heart Failure Prescribing

STUDY_SECTION_NAME: HSR-1 Health Care and Clinical Management[HSR1]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: LOS ANGELES

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The predoctoral and postdoctoral trainees of the training grant in “Molecular Toxicology” at UCLA will acquire expertise in how to perform research on the mechanisms whereby environmental pollutants cause disease. Great strides in the identification, appraisal, and amelioration of the toxicological risks of environmental pollutants are likely to emanate from such studies.

PI_NAMEs: ALLARD, PATRICK ;HANKINSON, OLIVER NMN (contact)

PROGRAM_OFFICER_NAME: SHREFFLER, CAROL A

PROJECT_TERMS: Molecular Toxicology;Training

PROJECT_TITLE: Training in Molecular Toxicology


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Narrative Continued progress toward solving today's complex health and scientific questions requires diverse perspectives and skills, but the ethnic and racial diversity of the U.S. scientific workforce remains remarkably low. This research will improve our understanding of how aspiring scientists from different backgrounds make decisions about, persist toward, and succeed in various science careers. This project also tests a novel group coaching approach, based on early results and well-tested social science theories, that addresses theoretical and practical reasons for stalled progress in diversifying the faculty ranks of colleges and universities.

PI_NAMEs: MCGEE, RICHARD  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Academy;Achievement;Address;biomedical scientist;career;college;Complex;Cross-Sectional Studies;Data;Decision Making;Doctor of Philosophy;doctoral student;Elements;Empirical Research;ethnic diversity;Ethnic Population;experience;Faculty;fluidity;Future;Gender;gender diversity;Government;Health;improved;Individual;insight;Intervention;Interview;Investments;Life;Long-Term Effects;Longitudinal Studies;Mentors;Modeling;Natural Sciences;novel;Participant;post-doctoral training;Privatization;programs;prospective;racial diversity;racial population;Randomized, Controlled Trials;Research;Science;Scientist;skills;Social Sciences;STEM field;Stream;Students;study population;Subgroup;success;Testing;theories;Time;Training;Translating;Translational Research;Underrepresented Populations;Underrepresented Students;Universities;Woman

PROJECT_TITLE: Integrated Empirical and Translational Research to Diversify the Scientific Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Sepsis;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative Sepsis results in the deaths of millions of humans worldwide because of a dysregulated immune response to infection. There are no effective therapies for sepsis beyond antibiotics and supportive care, so there is great unmet need in advancing our understanding of the host response to infection. In this proposal, we will generate new understanding of how platelet production from the spleen contributes to the immune response in sepsis.

PI_NAMEs: LOONEY, MARK ROBERTS (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acute;acute infection;Adrenergic Agents;adrenergic stress;Age;Antibiotics;Biogenesis;Blood Platelets;Bone Marrow;Cell Therapy;Cells;Cessation of life;Circulation;Complex;cytopenia;Data;design;Development;differential expression;effective therapy;Engraftment;Extramedullary;Functional disorder;Hematopoietic Stem Cell Mobilization;Hematopoietic stem cells;Heterogeneity;Homeostasis;Host Defense;Human;IL3 Gene;Immune;immune function;Immune response;Immunity;Immunologic Surveillance;Immunologics;immunopathology;immunoregulation;Incidence;individual response;Infection;Inflammation;intravital imaging;intravital microscopy;Knowledge;Life;Lung;Measures;Mechanical Stress;Mediator;Megakaryocytes;Megakaryocytopoieses;Methods;Morbidity - disease rate;mouse model;Mus;Nature;novel;novel therapeutic intervention;Organ;Organ failure;Organ Transplantation;pathogen;Peritonitis;pharmacologic;Phenotype;polymicrobial sepsis;Population;Process;Production;progenitor;response;Role;Sampling;Sepsis;septic;single-cell RNA sequencing;Site;Solid;Spleen;spleen transplantation;Stromal Cell-Derived Factor 1;Stromal Cells;Supportive care;Surface;targeted treatment;Techniques;Testing;Therapeutic;therapeutic evaluation;Thrombocytopenia;Thrombopoiesis;Transfusion;Transplantation;Validation

PROJECT_TITLE: Immunomodulation by splenic megakaryocytes and platelets in sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Nearly 40% of descendants from East Asia possess a genetic variant severely limiting their ability to metabolize reactive aldehydes. In addition, several other genetic differences in the lipid peroxidation pathway also occur in Asians which may impact organ injury, particularly during surgery. This project will develop tools in the basic science laboratory to better understand how genetic differences in the lipid peroxidation pathway may impact organ damage and translate these strategies to monitor and reduce organ damage in humans undergoing surgery.

PI_NAMEs: GROSS, ERIC RICHARD (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Aldehydes;Analgesics;Anesthesia procedures;Anesthetics;Asian Americans;Asian population;Basic Science;Biological;Biological Assay;Caring;Cause of Death;cell injury;Ethnic Origin;Far East;Functional disorder;Genetic;Genetic study;genetic variant;Health Care Costs;Human;Human Genetics;improved;insight;Knock-in Mouse;Laboratories;Lipid Peroxidation;Medical;Metabolism;Methods;Monitor;mortality;mouse model;novel;novel strategies;Operative Surgical Procedures;Organ;organ injury;Other Genetics;Pathway interactions;Persons;Phenotype;Population;precision medicine;programs;Quality of Care;Rodent;Time;tool;Translating;treatment strategy;TRP channel;United States

PROJECT_TITLE: Precision medicine for Asian Americans requiring anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: This grant award will support the Medical Scientist Training Program (MSTP) at the University of Maryland School of Medicine. The mission of our MSTP is to train a diverse and creative cadre of physician-scientists who will become leaders in their chosen fields of research, develop new knowledge and translate it to enhance clinical practice. This training will serve the nation by developing physician-scientists who can accelerate the progress of biomedical research from the laboratory to the direct benefit of patients.

PI_NAMEs: ROGHMANN, MARY-CLAIRE  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: MEMPHIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Olfactory dysfunction is an early indicator of several major neurological diseases in humans including Alzheimer’s and Parkinson’s diseases. As the loss of cholinergic neurons is a hallmark in both of these diseases, it is particularly important to understand the basic mechanisms by which cholinergic modulation affects the neuronal circuits involved in sensory processing and sensory discrimination which could help in the diagnosis and treatment of these diseases. This proposal will elucidate how acetylcholine release in primary cortical sensory structures impacts sensory coding, stimulus salience, and perception and will provide insights into sensory and cognitive impairments with disturbances in cholinergic function.

PI_NAMEs: FLETCHER, MAX L (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acetylcholine;Address;Affect;Alzheimer's Disease;Anesthesia procedures;Animals;awake;basal forebrain;basal forebrain cholinergic neurons;Behavior;Behavioral;Behavioral Assay;behavioral study;Brain;Brain region;Calcium;calcium indicator;cell type;Cells;Characteristics;cholinergic;Cholinergic Fibers;cholinergic neuron;Cholinergic Receptors;Code;Data;DDX26 gene;Detection;Diagnosis;Discrimination;Disease;Event;experimental study;Fiber;genetic manipulation;Goals;Head;Human;Image;Impaired cognition;improved;in vivo;insight;Knowledge;Learning;Mediating;microendoscope;Mus;Nervous System Disorder;neural circuit;neuronal circuitry;Neurons;novel;odor discrimination;Odors;olfactory bulb;Olfactory dysfunction;Olfactory Pathways;Output;Parkinson Disease;Perception;Pharmacology;Physiological;piriform cortex;Play;Population;Process;Receptor Activation;response;Role;Sensory;sensory cortex;sensory discrimination;Sensory impairment;sensory input;Signal Transduction;Smell Perception;Stimulus;Structure;System;Testing;two-photon;Work

PROJECT_TITLE: Cholinergic modulation of olfactory coding.

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: The mission of the University of Utah MD-PhD program is to graduate highly valued physician-scientists for the biomedical workforce. The proposed University of Utah MSTP will provide highly integrated MD-PhD training that draws on Utah’s outstanding research and clinical resources and its highly supportive training environment. This training will prepare students for independent careers as leaders at the interface of research and medicine.

PI_NAMEs: KAY, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TITLE: University of Utah Medical Scientist Training Program


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: MILWAUKEE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative About one-third of patients afflicted with epilepsy have repeated seizures, which dramatically increases the risk of unexpected seizure-related death (SUDEP) thought to occur due to suppression of breathing and heart rate. Here, we will characterize the negative consequences of repeated seizures on breathing and heart rate, pathological changes within brainstem regions critical for regulating these functions, and test interventions that may improve outcomes in a unique mutant rat with sound-induced seizures. Completion of these proposed studies will identify molecular pathways leading to cardiorespiratory dysfunction/failure in rats in order to develop new therapies in human epilepsy patients to prevent or reduced the risk of SUDEP.

PI_NAMEs: HODGES, MATTHEW ROBERT (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Acute;Address;Adenosine;Affect;Animal Model;anti-epileptic agents;Anti-Inflammatory Agents;Antibodies;Apnea;Astrocytes;audiogenic seizure;Blood Pressure;Brain;Brain Stem;Breathing;Cause of Death;Cell Death;Cell Nucleus;Cell Physiology;Cells;Cessation of life;Chronic;Cicatrix;cohort;Data;Electroencephalography;Epilepsy;epileptiform;Event;Exposure to;Failure;Female;Fluoxetine;Functional disorder;Gene Expression Profile;Genes;glial activation;Glial Fibrillary Acidic Protein;Goals;Heart Arrest;Heart Rate;high risk;Human;Hypoxia;Impairment;improved outcome;Inflammation;Inflammatory;insight;Interleukin-1;Interleukin-10;Interleukins;Intervention;Intractable Epilepsy;inward rectifier potassium channel;Knowledge;Lead;male;Mediating;Mediator;Membrane Potentials;Microglia;Modeling;Molecular;mortality;mutant;Mutation;Nervous System Disorder;neural circuit;neural network;neuroinflammation;Neuromodulator;Neuronal Plasticity;Neurons;neuroregulation;new therapeutic target;novel;novel therapeutics;Nuclear RNA;nucleus ambiguus;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Phenotype;Potassium Channel;pre-clinical;preBotzinger complex;prevent;Rattus;receptor;Recurrence;Reflex action;Reproducibility;respiratory;response;Risk;risk mitigation;Seizures;Selective Serotonin Reuptake Inhibitor;Serotonergic System;Serotonin;Signal Pathway;Signal Transduction;Site;sound;Stereotyping;sudden unexpected death in epilepsy;System;Technology;Testing;Therapeutic Intervention;therapeutic target;Time;Tissue-Specific Gene Expression;Tissues;Tonic - clonic seizures;transcriptome sequencing;ventilation

PROJECT_TITLE: Progressive seizure-induced cardiorespiratory dysfunction in a novel mutant rat model of seizure disorder

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: Project Narrative Adductor laryngeal dystonia (AdLD) is a neurological voice disorder characterized by laryngeal spasms and increased vocal effort, symptoms that significantly impact patients' quality of life. Current medical management is not curative and involves invasive injections of toxin into the larynx several times a year to mitigate symptoms. The development of new, long-lasting treatments is hampered by a lack of sensitive and specific measures of vocal function in AdLD. This proposal will construct and validate automated measures of vocal function to facilitate future clinical trials to improve voice in AdLD.

PI_NAMEs: STEPP, CARA E. (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Aftercare;Auditory;Auditory Perception;botulinum neurotoxin injection;Botulinum Toxins;Characteristics;Clinical;Clinical assessments;clinical care;clinical outcome measures;clinical practice;Clinical Trials;cohort;Consumption;Data;Data Set;design;Detection;Development;Disease;Dysphonia;Frequencies;Future;Grant;improved;Individual;Injections;kinematics;Laryngeal muscle structure;Larynx;Measures;Medical;Modeling;Muscle Tension;Neurologic Voice Disorder;novel strategies;Observational Study;Outcome;Outcome Measure;Output;Patients;Perception;Physiological;predictive modeling;Process;psychosocial wellbeing;Quality of life;ROC Curve;Sampling;Sensitivity and Specificity;Severities;Spasm;Spastic Dysphonias;Speech Acoustics;Speed;Statistical Models;Stroboscopy;Symptoms;Testing;Time;Toxin;Translating;Treatment Efficacy;Validation;vocal cord;Voice;Voice Disorders;Voice Quality

PROJECT_TITLE: Objective Measures for Clinical Assessment of Voice Disorders


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biotechnology;Clinical Research;Gene Therapy;Genetics;Hearing Loss;Human Genome;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Permanent, disabling hearing loss in children is most commonly caused by genetic mutations. Not all types of hearing loss are effectively treated by hearing aids or the surgical method of cochlear implantation and previous research has shown that patients with mutations in the gene TMRPSS3, one of the most common causes of genetic hearing loss, may have worse speech perception outcomes after cochlear implantation. In this grant, we aim to improve our understanding of the complex interplay between genetics and cochlear implant speech perception outcomes using human genomics, a new mouse model for TMPRSS3 genetic hearing loss, and a new gene therapy approach for this form of hearing loss.

PI_NAMEs: SHEARER, AIDEN ELIOT (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acoustic Nerve;Adult;Affect;alternative treatment;Applications Grants;autosome;Bypass;Calcium;career;Cell Death;Child;Childhood;childhood hearing loss;Clinical;Cochlea;Cochlear implant procedure;Cochlear Implants;Complex;congenital hearing loss;CRISPR/Cas technology;Data;deaf;deafness;Development;Disabling;DNA Sequence Alteration;effective therapy;Electrocochleographies;experience;experimental study;functional restoration;Funding;Future;gene therapy;Gene therapy trial;Genes;Genetic;Genetic Risk;Genetic Variation;Genomics;Genotype;Goals;Grant;Hair Cells;Health;Hearing;Hearing Aids;hearing impairment;hearing restoration;hereditary hearing loss;Human;Human Genetics;human genomics;improved;In Vitro;in vivo;indexing;Individual;Inner Hair Cells;innovation;Knockout Mice;Language Development;language outcome;large-conductance calcium-activated potassium channels;Lead;Methods;mouse model;Mus;Mutation;Neurons;Newborn Infant;novel;novel therapeutic intervention;Operative Surgical Procedures;Organ of Corti;Outcome;Outer Hair Cells;Patients;Pediatric cohort;Phenotype;Postoperative Care;Postoperative Period;Potassium Channel;preoperative counseling;progressive hearing loss;promoter;Proteins;Quality of life;Research;Risk;Role;Scientist;Sensory Disorders;sensory prosthesis;Serine Protease;single-cell RNA sequencing;Social Development;Speech;Speech Development;Speech Perception;spiral ganglion;Statistical Models;Surgeon;Synapsins;Testing;Time;Training;Variant;vector

PROJECT_TITLE: Spiral Ganglion Health: from Genomics to Gene Therapy

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative The 26S proteasome is the main proteolytic molecular machine in eukaryotic cells that regulates numerous vital processes. This proposal aims to understand in molecular detail the biochemistry, mechanics, and regulation of substrate recognition, ATP-dependent unfolding, and processing by the 26S proteasome and related protein translocases of the AAA+ family, including the Cdc48/p97.

PI_NAMEs: MARTIN, ANDREAS  (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: 26S proteasome;Address;Affect;ATP Hydrolysis;Binding;Biochemical;biochemical tools;Biochemistry;biological adaptation to stress;Biological Assay;Cell division;Cell Survival;Cells;Characteristics;Code;Complex;conformational conversion;Coupled;Cryoelectron Microscopy;Data;Deubiquitination;Development;Dissection;Electron Microscopy;encryption;Engineering;Eukaryotic Cell;Family;Fluorescence;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;Genetic Transcription;Goals;Grant;Human;human disease;In Vitro;Individual;insight;interdisciplinary approach;Intervention;Kinetics;Label;Length;Malignant Neoplasms;Measurement;Mechanics;Mediating;Medical;Modeling;Modification;Molecular;Molecular Conformation;Molecular Machines;Motor;multicatalytic endopeptidase complex;Mutation;Neurodegenerative Disorders;particle;Pathway interactions;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacologic Substance;Play;Polyubiquitin;Positioning Attribute;Process;Protac;protein degradation;Protein Engineering;protein folding;Proteins;proteostasis;Quality Control;receptor;Recombinants;reconstitution;Regulation;Research;Resolution;Role;Series;single molecule;single-molecule FRET;Site;small molecule;small molecule inhibitor;Structure;Substrate Interaction;System;tool;translocase;Ubiquitin;ubiquitin isopeptidase;unfoldase;unnatural amino acids;valosin-containing protein;Work;Yeasts

PROJECT_TITLE: ATP-Dependent Protein Unfolding and Translocation by the Eukaryotic Proteasome

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Primary Health Care;Social Determinants of Health

PHR: PUBLIC HEALTH NARRATIVE COVID-19 is an unprecedented public health threat in modern times, especially for middle age and older adults with a chronic illness; beyond the threat of infection, the pandemic may have a longer-term impact on their mental and physical health. We have a unique opportunity to examine the psychosocial and healthcare experiences of a novel cohort of adults with chronic conditions - from before the pandemic’s onset through 5 years after - allowing us to inform public health and health system initiatives by identifying 1) individual risk factors of persistent self-management problems, and 2) viable, modifiable targets for intervention.

PI_NAMEs: BAILEY, STACY C;FEDERMAN, ALEX D;WOLF, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acute;Adherence;Adult;Affect;Age disparity;Alcohols;Anxiety;authority;Award;Biometry;Caring;Chicago;Chronic;Chronic Disease;cohort;Cohort Studies;Collection;Communities;comorbidity;COVID-19;COVID-19 impact;COVID-19 mortality;COVID-19 stress;Data;Data Collection;Diet;Disease;Disease Outbreaks;Disease Outcome;Electronic Health Record;Ethnic Origin;Exhibits;experience;follow up assessment;Fright;functional status;Gender;Grief reaction;Health;Health behavior;health care service;health data;health disparity;health literacy;health management;Health Professional;Health Status;Health system;Healthcare;Individual;Infection;Infection prevention;Intervention;Interview;Life Style;Long COVID;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Mediating;Medical;Mental Depression;Mental Health;middle age;Modernization;Monitor;New York City;novel;older adult;Outcome;outcome disparities;pandemic disease;pandemic impact;Parents;Participant;Patient Outcomes Assessments;Patients;Personal Satisfaction;Persons;Physical activity;physical conditioning;physical inactivity;Policy Maker;pre-pandemic;Prevalence;Preventive Health Services;Psychosocial Assessment and Care;Public Health;Race;Recommendation;Reporting;Research Personnel;response;Risk Factors;Role;Self Efficacy;Self Management;sex;sex disparity;Site;Sleep;Sleep disturbances;Social Distance;Social isolation;Social support;Socioeconomic Status;socioeconomics;Stress;substance use;Surveys;telehealth;treatment adherence;Virus;Voice;Weight Gain

PROJECT_TITLE: Long-Term Impact of the COVID-19 Pandemic on Self-Management of Chronic Conditions: The C3 Study

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE  Cells respond to their surroundings by perceiving extracellular signals, which trigger intracellular signaling events that shape how energy resources, including lipids, are allocated between fundamental cellular processes. The goal of this project is to elucidate the molecular mechanisms by which pro-growth signaling remodels lipid metabolism pathways to maintain organismal energy homeostasis. This work will identify new proteins and signaling networks that participate in metabolic regulation, as well as yield mechanistic insight into the underlying causes of a wide range of human metabolic diseases and cancers.

PI_NAMEs: DOWEN, ROBERT HOUSTON (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Biochemical;biological adaptation to stress;biological systems;Caenorhabditis elegans;cell growth;Cell Physiology;Cell Proliferation;cell type;Cells;Complex;Development;Environment;Event;extracellular;FRAP1 gene;functional genomics;Genes;genetic approach;Genetic Transcription;Genomic approach;Goals;Growth;Homeostasis;Human;insight;interdisciplinary approach;Intestines;lipid metabolism;Lipids;Malignant Neoplasms;MAP Kinase Gene;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Mitogen-Activated Protein Kinases;Modeling;Molecular;Nutritional;Pathway interactions;programs;Proteins;Regulation;Research;Resources;Shapes;Signal Pathway;Signal Transduction;Signal Transduction Pathway;System;Tissues;Work

PROJECT_TITLE: Regulation of lipid homeostasis by proliferative signaling pathways


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: One of our long-term goals is to aid in the development of effective HIV cure strategies by gaining a better understanding of the host processes by which persistent reservoirs of HIV are established and maintained in the body despite long-term use of antiretroviral therapy. Notwithstanding the fact that the gastrointestinal (GI) tract is a major site of HIV replication and pathogenesis in people living with HIV, the relative contribution of the Gl tract to the HIV reservoir is unknown as well as the impact of the GI microbiome. Our objective is to implement an innovative in vivo model system to increase our understanding of how the GI tract and in particular how the presence of the GI microbiome contributes to HIV persistence.

PI_NAMEs: GARCIA-MARTINEZ, J. VICTOR ;SARTOR, RYAN B;WAHL, ANGELA RAQUEL (contact)

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Address;antiretroviral therapy;Binding;Biological Models;Blood;Blood Cells;BLT mice;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Development;Disease remission;DNA;dysbiosis;efficacy evaluation;Frequencies;Gastrointestinal tract structure;Genetic Transcription;Germ-Free;Gnotobiotic;Goals;gut microbiome;Histone Acetylation;Histone Deacetylase Inhibitor;HIV;HIV Core Protein p24;HIV Infections;humanized mouse;Immune;immune activation;In Vitro;in vivo;in vivo Model;Infection;Inflammation;innovation;Interruption;Intestinal Mucosa;Intestines;Kinetics;Knowledge;latent infection;Lymphocyte;Maintenance;Metabolism;microbial;microbial products;microbiome;microbiota;Modeling;mouse model;Mucosal Immunity;multidisciplinary;Pathogenesis;Pathway interactions;Patients;peripheral blood;Persons;Physiological Processes;Plasma;Process;Rectum;Reporting;Reproducibility;Research;Rest;RNA;Role;Site;Tissues;Transcript;Viral;viral rebound;Viremia;virtual;Virus

PROJECT_TITLE: Impact of the gastrointestinal microbiome on HIV reservoirs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-J(50)]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: NARRATIVE The pandemic brought on by SARS-CoV-2 has profoundly impacted health and care for veterans, who are generally older, sicker, more rural, and more economically vulnerable than the overall U.S. population. Veterans are likely to face lasting risks related to disruptions of care and healthcare has been hindered by clinic closures, interruptions in public transportation, financial instability and self-imposed isolation. Veterans with chronic diseases may have missed medical appointments, lack access to critical prescription medication and routine monitoring of disease, resulting in poor control, serious adverse outcomes including lower extremity amputation and stroke, hospitalizations and mortality. These disruptions and varied responses across VA Medical Centers provide an unprecedented opportunity to examine the impact of widespread changes in care delivery on disease outcomes and the extent to which health disparities have widened during the pandemic. Results from this study will inform post-pandemic care throughout the VA and will provide a blueprint for responding to future crises.

PI_NAMEs: HUNT, KELLY J (contact);NEELON, BRIAN

PROJECT_TERMS: 2019-nCoV;Accounting;Address;adverse outcome;American;Amputation;Area;Atherosclerosis;Black race;Businesses;Cardiology;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;care delivery;Caring;Censuses;Cessation of life;Chronic;Chronic Disease;Clinic;cohort;college;Community Healthcare;Complex;COVID-19 pandemic;dashboard;Data;Data Display;Death Rate;Decision Making;Diabetes Mellitus;Disease;Disease Outcome;Disparity;disparity reduction;Drug Prescriptions;Economics;Emergency department visit;Equity;Ethnic Population;Evaluation;Face;follow-up;Future;future pandemic;geographic disparity;Geographic Information Systems;Health;Health Care Costs;health care delivery;health care service;health disparity;Healthcare;Heart Diseases;high risk;Hispanic;Hospitalization;Hospitals;Hypertension;improved;Individual;individual patient;Inpatients;insight;Intelligence;Interruption;Intervention;Kidney Failure;Knowledge;Leadership;Lower Extremity;Measures;medical appointment;Medical center;Methodology;model design;Modeling;Monitor;mortality;Nature;Not Hispanic or Latino;operation;Outcome;outcome disparities;pandemic disease;pandemic impact;Patient Care;Patients;Persons;Pharmaceutical Preparations;Phase;Policies;Population;Positioning Attribute;post-pandemic;pre-pandemic;Prevalence;Primary Care;primary care visit;Provider;Race;racial population;Recording of previous events;Research;residence;response;Retrospective cohort;Risk;Risk Factors;Rural;Social Conditions;social determinants;Social Distance;social vulnerability;Social Work;socioeconomic disparity;South Carolina;spatiotemporal;Statistical Methods;Statistical Models;statistics;Stroke;Suspensions;System;Telephone;Testing;tool;Transportation;trend;urban residence;Veterans;Visit;Visual;Workplace

PROJECT_TITLE: Examining linkages between disrupted care and chronic disease outcomes during the COVID-19 pandemic: a VAMC level spatio-temporal analysis

STUDY_SECTION_NAME: HSR-5 Health Care System Organization and Delivery and Women's Health[HSR5]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Psychosis;Serious Mental Illness

PHR: Project Narrative Reducing and predicting unplanned readmission are major unmet needs of psychiatric care. This project will use electronic health record databases and computational linguistic approaches to develop a psychiatric specific temporal relation annotation scheme, create readmission prediction models, and compare against expert human performance. Developing readmission prediction tools could not only be used to help target the delivery of resource-intensive interventions to those patients at greatest risk, but also reduce psychiatric health-care costs.

PI_NAMEs: HALL, MEI-HUA ;MILLER, TIMOTHY A (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Algorithms;Apache;Appearance;Clinical;Clinical Trials;Communities;Computational Linguistics;Data;data resource;Data Set;Databases;Disabling condition;Economic Burden;Electronic Health Record;Evaluation;Event;experience;explainable machine learning;Family;Feedback;Foundations;Future;Graph;graph neural network;Guidelines;Health;Health Care Costs;Healthcare;hospital readmission;Hospitals;Human;improved;Information Retrieval;Intake;Interpersonal Relations;Intervention;Intervention Trial;Knowledge;large datasets;Learning;learning community;learning strategy;Machine Learning;machine learning algorithm;machine learning classifier;machine learning prediction;Manuals;Measures;Medical;Mental disorders;Mental Health Services;Methods;model building;Modeling;Moods;multiple datasets;National Institute of Mental Health;natural language;Natural Language Processing;Occupations;open source;open source tool;Output;patient subsets;Patients;Performance;personalized predictions;Phenotype;Play;predictive modeling;predictive tools;Preventive measure;Process;psychiatric inpatient;Psychiatric therapeutic procedure;Psychiatry;Psychoses;Publications;readmission risk;repository;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;Scheme;Standardization;Step training;Strategic Planning;Structure;structured data;substance use;suicidal;Symptoms;System;targeted delivery;Testing;Text;Time;timeline;tool;Training;training data;translational study;unsupervised clustering;Update;Validation;Work

PROJECT_TITLE: Modeling Temporality with Natural Language Processing to Predict Readmission Risk of Patients with Psychosis

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Conditions Affecting the Embryonic and Fetal Periods;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Antibiotics are among the most commonly used medications in pregnancy, yet the potential of teratogenicity and fetal toxicity of antibiotics in humans remains an area largely devoid of evidence. To address this critical information gap, we propose to generate high-quality evidence on the comparative safety of antibiotic treatment options for common bacterial infections during pregnancy by leveraging existing data on over 4.5 million pregnancies. The findings from this research will directly inform the treatment decisions regarding antibiotics selection in pregnant women and women of reproductive age who may become pregnant.

PI_NAMEs: ZHU, YANMIN  (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;adverse maternal outcomes;adverse outcome;Age;animal data;Antibiotic Therapy;Antibiotics;antimicrobial;Area;Bacterial Infections;Benefits and Risks;Cellulitis;Centers for Disease Control and Prevention (U.S.);Cephalosporins;Chlamydia;Clindamycin;Clinical;cohort;comparative safety;comparison group;Confounding Factors (Epidemiology);Congenital Abnormality;Data;Data Sources;Databases;detection method;early pregnancy;Ensure;Evaluation;Exposure to;fetal;Fetus;Fluoroquinolones;Fosfomycin;Goals;Gonorrhea;Human;Infection;Lifelong disability;Lower Respiratory Tract Infection;Macrolides;malformation;Medicaid;medication safety;member;Neonatal;Neonatal Jaundice;neonatal morbidity;Neonatal Mortality;Nitrofurantoin;novel;Observational Study;optimal treatments;Outcome;Penicillins;Pharmaceutical Preparations;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal exposure;prevent;Privatization;reproductive;Research;Residual state;Respiratory Tract Infections;Risk;risk prediction;Safety;Sexually Transmitted Diseases;Signal Transduction;skin abscess;Specific qualifier value;Spontaneous abortion;Teratogens;Tetracyclines;Toxic effect;treatment strategy;Trimethoprim-Sulfamethoxazole;United States Food and Drug Administration;United States Preventative Services Task Force;Upper respiratory tract;Urinary tract infection;vaccine safety;Vulnerable Populations;Woman

PROJECT_TITLE: Comparative Safety of Antibiotics for Common Bacterial Infections During Pregnancy


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Neurosciences;Sleep Research

ORG_CITY: MADISON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PUBLIC HEALTH RELEVANCE Disruptions of sleep-activity cycles account for a wide range of diseases affecting behavior, neurology, metabolism, and muscle physiology. Circadian rhythms drastically alter animal behavior through a diversity of actions on cellular targets throughout the body. We will perform basic research in larval zebrafish to understand the mechanisms and interactions of circadian effects on cells and systems spanning the body.

PI_NAMEs: EHRLICH, DAVID EDWARD (contact)

PROJECT_TERMS: Activity Cycles;Affect;Animal Behavior;Animals;Arousal;Basic Science;Behavior;Behavioral;Biomechanics;Brain;Cells;cellular targeting;circadian;circadian regulation;Circadian Rhythms;Complex;Computer Models;Disease;Electrophysiology (science);experience;experimental study;Exposure to;Functional Imaging;Gene Expression Profiling;genetic approach;Goals;in vivo;Lesion;Light;Metabolism;Modeling;Muscle;muscle physiology;Nervous System;Neurology;Neurons;Organ;Output;Pacemakers;Physiological;Physiology;public health relevance;Research;Research Design;Resolution;Shapes;Signaling Molecule;sleep behavior;Sleep disturbances;System;Testing;Zebrafish

PROJECT_TITLE: Circadian regulation of brain and body in larval zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE  Apert syndrome is a devastating genetic syndrome with abnormal skull development and strabismus, or eye misalignment. This research proposal will use a model for Apert syndrome to examine why patients have abnormal muscles around the eye and what might be causing their abnormal vision using state-of-the-art techniques in muscle biomechanics and genetics. Gene therapy will also be tested using this model to investigate innovative therapies for patients with strabismus in Apert syndrome.

PI_NAMEs: RUDELL, JOLENE  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Affect;Aftercare;Amblyopia;Anatomy;Animals;Apert syndrome;Area;Atrophic;base;Biological Assay;Biomechanics;Blindness;bone;California;career;career development;Cells;Childhood;Clinical;comparison control;Complex;craniofacial;Craniofacial Abnormalities;Craniosynostosis;Data;Dependovirus;Development;Development Plans;developmental disease;Disease;DNA Sequence Alteration;Eye;Eye Abnormalities;Eye Movements;Failure;FGFR2 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptor 2;Fibroblast Growth Factor Receptors;Foundations;Functional disorder;Future;gain of function mutation;gene therapy;Genetic;Goals;hands on research;Histology;Human;Image;in vivo;Incidence;Inferior;innovation;Innovative Therapy;interest;Investigation;Knock-in;Limb structure;Live Birth;Magnetic Resonance Imaging;Mentors;Modeling;mouse model;Mus;Muscle;Muscle Contraction;Muscle function;muscle physiology;muscle progenitor cell;Muscular Atrophy;muscular structure;Musculoskeletal;mutant;Mutant Strains Mice;Mutation;Myopathy;Myosin ATPase;nerve supply;Neurons;novel;novel therapeutics;Ocular orbit;Operative Surgical Procedures;Ophthalmology;Optokinetic nystagmus;orbit muscle;Other Genetics;Pathologic;Pathology;Patients;Play;programs;Proliferating;promoter;Property;Protein Isoforms;psychosocial;Quality of life;Records;Reflex action;Research;research facility;Research Project Grants;Research Proposals;response to injury;Role;Scientist;Signal Transduction;Skeletal Muscle;skull abnormality;small hairpin RNA;Strabismus;success;surgery outcome;Synapses;Syndrome;Techniques;Testing;Tissues;Training;Universities;Vision;Visual impairment

PROJECT_TITLE: Role of a craniosynostosis associated fibroblast growth factor receptor mutation in extraocular muscles


NIH_SPENDING_CATS: Cardiovascular;Hypertension

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Public Health Relevance: Hypertension is fundamentally a vascular inflammatory disease that causes increased constriction and impaired relaxation of blood vessels. This inflammation is associated with excess production of reactive oxygen species (ROS) and we found that LRRC8 family anion channels not only regulate the production of these ROS, they may also provide a pathway by which a very critical oxidant, superoxide anion, enters vascular smooth muscle cells and impairs vasodilation. This proposal will define the role of these channels in hypertension and identify novel therapeutic strategies for the treatment of vascular inflammation.

PI_NAMEs: LAMB, FRED S (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Angiotensin II;Anions;antioxidant enzyme;antioxidant therapy;Antioxidants;Apoptosis;Binding;Biological;Biological Assay;Blood Pressure;Blood Vessels;Cardiovascular Diseases;Cause of Death;Cells;channel blockers;chronic inflammatory disease;Compensation;constriction;cytokine;Cytoplasm;defined contribution;Disease;Endocytosis;Environment;Exhibits;experimental study;extracellular;Family;Feedback;Free Radicals;Goals;Hydrogen Peroxide;Hypertension;hypertension treatment;Hypertrophy;Impairment;Inflammation;Inflammatory;Infusion procedures;insight;knock-down;Knockout Mice;Leucine-Rich Repeat;Link;Mass Spectrum Analysis;Medial;Mesentery;Methods;migration;Molecular;Monomeric GTP-Binding Proteins;Mus;Myocardial Ischemia;Myography;myosin phosphatase;NADPH Oxidase 1;Nitric Oxide;novel;novel therapeutic intervention;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;patch clamp;Pathology;Pathway interactions;Perfusion;Permeability;Peroxonitrite;Physiological;pressure;Production;Proliferating;Property;Protein Family;Protein Isoforms;Proteins;public health relevance;Reactive Nitrogen Species;Reactive Oxygen Species;Regulation;Relaxation;Resistance;response;Risk Factors;Role;Scaffolding Protein;selective expression;Signal Pathway;Signal Transduction;Signaling Molecule;Smooth Muscle Myocytes;spatiotemporal;Stroke;Superoxides;TNF gene;TNFRSF1A gene;treatment strategy;ubiquitin-protein ligase;Vascular Diseases;vascular inflammation;Vascular Smooth Muscle;vasoactive agent;Vasodilation;Vasodilator Agents;Vasomotor;Work

PROJECT_TITLE: Anion channel regulation of vascular superoxide signaling in hypertension

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  Myelodysplastic syndromes (MDS) are a group of diverse malignant hematological disorders that originate from hematopoietic stem cells (HSCs). Here, we will investigate the novel role of ALKBH5 in the maintenance of hematopoietic stem/progenitor cells (HSPCs) in response to oxidative stress, and elucidate the underlying mechanism. Our study will provide new insights into molecular mechanism that mediates the leukemic transformation of HSPCs, thereby leading to the identification of a new therapeutic strategy for targeting pre-leukemic stem cells in MDS patients.

PI_NAMEs: QIAN, ZHIJIAN  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: aging process;Apoptosis;Biological Process;CD34 gene;Cell Death;cell injury;Cell Maintenance;Cells;Chromatin;crosslinking and immunoprecipitation sequencing;demethylation;Development;DNA Damage;DNA lesion;DNA Repair;Dysmyelopoietic Syndromes;epigenetic regulation;Functional disorder;Gene Expression;Gene Expression Regulation;genome integrity;Genome Stability;Genomic Instability;Goals;Growth;Hematological Disease;Hematopoietic;hematopoietic stem cell expansion;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Heterozygote;Histone Deacetylase;Human;Human Cell Line;In Vitro;in vivo;Induction of Apoptosis;insight;knock-down;leukemic stem cell;leukemic transformation;Long-Term Effects;Maintenance;Malignant - descriptor;Malignant Neoplasms;Mediating;Mediator;Messenger RNA;Methylation;Modeling;Modification;Molecular;Mus;Mutagenesis;novel;novel therapeutic intervention;Oncogene Activation;overexpression;Oxidative Stress;Pathway interactions;Patients;Phenocopy;Physiological;Play;Polyribosomes;Post-Transcriptional Regulation;Post-Translational Protein Processing;posttranscriptional;Preleukemia;prevent;public database;Reactive Inhibition;Reactive Oxygen Species;repaired;response;Ribosomes;RNA;RNA methylation;Role;self-renewal;Source;Speed;stem cell function;stem cells;Stress;System;Testing;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;tumorigenesis;Up-Regulation;Xenograft procedure

PROJECT_TITLE: The role of ALKBH5-mediated RNA demethylation in the maintenance of genomic stability in HSPCs

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE The outcome of this study will provide crucial insights into the neurobiological changes that could account for the broad range of psychiatric disorders in youth who have experienced high early life adversity, as well as the differences between those who are more versus less vulnerable. Knowledge of these factors and mechanisms would enable the early identification of at-risk youth, allowing novel and timely prevention strategies, and the development of personalized interventions for adversity-exposed youth that target the specifically affected neural and biological pathways.

PI_NAMEs: BIRN, RASMUS MATTHIAS (contact);HERRINGA, RYAN J

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: Address;Adolescent;Affect;Age;Behavior;Behavioral;Biological;Brain;Childhood;childhood adversity;Cognitive;cognitive development;cognitive load;cohort;community violence;Conflict (Psychology);Coupled;Crime;critical developmental period;Data;Development;Dimensions;Disease;early experience;Early identification;early life adversity;early life stress;Emotional;experience;Exposure to;Family;Foundations;Goals;Growth;Image;indexing;Individual;Individual Differences;insight;Intervention;Knowledge;Longitudinal Studies;Machine Learning;machine learning prediction;Maps;Mental disorders;Methods;Modality;Modeling;multidisciplinary;Neighborhoods;neural;neurobiological mechanism;Neurobiology;neuroimaging;novel;Onset of illness;Outcome Study;Pathway interactions;personalized intervention;physical abuse;predictive marker;Prevalence;Prevention strategy;Properdin;prospective;psychiatric symptom;Psychopathology;Puberty;Research;Research Design;Research Personnel;resilience;Resistance;Rest;Risk;risk prediction;Sample Size;sex;Sex Differences;Sexual abuse;Social support;Symptoms;System;Time;Validation;Violence;Work;Youth

PROJECT_TITLE: The impact of early life adversity on brain network development in youth


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Cancer research is dependent on the availability of high-quality biospecimens linked to patient information from clinical trials. The EET Biospecimen Bank will collect, process, bank, and distribute biospecimens from cancer patients enrolled on NCI-sponsored early-phase clinical trials. These biospecimens will eventually be used to study different types of cancer, and the results of this research will benefits patients through discovery of targeted therapy and/or improved outcomes and survival with the ultimate goal of cancer prevention and cure.

PI_NAMEs: NICOL, KATHLEEN  (contact);RAMIREZ MILAN, NILSA DEL CARMEN

PROGRAM_OFFICER_NAME: MAKHLOUF, HALA

PROJECT_TERMS: anti-cancer research;anti-cancer therapeutic;biobank;Biological Specimen Banks;Breast;Cancer Patient;cancer prevention;cancer recurrence;Cancer Therapy Evaluation Program;cancer type;Clinical;Clinical Data;Clinical Trials;Clinical Trials Information for Patients;Clinical Trials Network;Collection;Colon;Coupled;Data;data management;Development;early phase clinical trial;Ensure;Epidemiology;Evaluation;experience;Funding;Goals;Guidelines;Human;Immunologic Monitoring;improved;improved outcome;Information Systems;Infrastructure;Investigational Therapies;laboratory equipment;leukemia;Link;Lung;Lymphoma;Malignant Neoplasms;Marketing;Medidata;Melanoma;Multiple Myeloma;National Cancer Institute;Oncology;operation;Operative Surgical Procedures;Outcome;participant enrollment;Pathologic;Patients;Pediatric Hospitals;Pediatric Oncology Group;Pharmaceutical Preparations;Phase;Policies;Procedures;Process;Prostate;Qualifying;Quality Control;Radiology Specialty;Recording of previous events;Reporting;Research;Research Design;Research Institute;Research Personnel;Resources;Sampling;Southwest Oncology Group;Standardization;targeted treatment;Technology;Therapeutic Agents;therapy outcome;tumor;Work;working group

PROJECT_TITLE: (EET Biobank)  NCI Early-Phase and Experimental Clinical Trials Biospecimen Bank


NIH_SPENDING_CATS: Genetics;Infertility;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE The chromatin state at enhancers is well-defined, but it remains unknown how each feature of enhancer chromatin contributes to overall enhancer activity. This proposal will determine novel principles regulating p300 activity during pluripotency and pre-implantation development. Understanding developmental enhancer activation may provide insight into the pathogenesis of many diseases and syndromes in which enhancer dysregulation has been implicated, including developmental syndromes and cancer.

PI_NAMEs: BANASZYNSKI, LAURA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acetate-CoA Ligase;Acetyl Coenzyme A;Acetylation;Acetyltransferase;Amaze;Binding;Binding Proteins;Biological;Biological Assay;Biological Process;Biology;cell fate specification;Cell Physiology;cell type;Cells;Chemicals;Chromatin;Defect;Deposition;Development;Disease;early pregnancy loss;Embryo;embryonic stem cell;Enhancers;EP300 gene;epigenetic regulation;Event;experimental study;Failure;Family;Gene Expression;Genes;Genetic Enhancer Element;Genetic Models;Genetic Transcription;Genomics;Goals;Histone H3;Histone H3.3;Histones;human disease;human model;improved;in vivo;Infertility;inhibitor;insight;Knock-in;Knowledge;Link;Lysine;Malignant Neoplasms;Mediating;Modeling;Molecular;Mouse Embryonic Stem Cells;mouse model;novel;Nuclear;p300/CBP-Associated Factor;Pathogenesis;Pathologic;Phosphorylation;Play;pluripotency;Pre-implantation Embryo Development;Process;protein protein interaction;Proteins;Proteomics;recruit;Regenerative Medicine;Regulatory Element;Role;scaffold;Specific qualifier value;Syndrome;Testing;Time;tool;Transcription Coactivator;transcription factor;Transcriptional Activation;Variant;Work

PROJECT_TITLE: Mechanisms of p300 Activation During Pluripotency and Differentiation.

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Black patients with lung cancer in the United States experience disparities in quality of care and outcomes across the spectrum of the disease. This proposal is relevant to public health because we will identify modifiable societal and health system factors that are associated with these disparities and learn about strategies to address racial disparities in lung cancer care directly from stakeholders in the community and health care settings. This research will provide concrete information about factors that perpetuate, and mitigate, lung cancer disparities, with the ultimate goal of providing equitable care for all lung cancer patients, regardless of race.

PI_NAMEs: GROSS, CARY P. (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accidents;Accounting;Address;Administrator;Adopted;Area;beneficiary;black patient;Black race;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;Caring;Cause of Death;Characteristics;Cluster Analysis;Communities;Community Healthcare;community setting;contextual factors;County;Data;Diagnosis;Dimensions;Disease;Disparity;disparity reduction;Ensure;Equity;experience;Geographic Locations;Geography;Goals;health assessment;health care delivery;health care settings;health equity;Health Policy;Health Service Area;health service use;Health Services Research;Health system;Healthcare;Healthcare Systems;Hospitals;improved;Individual;innovation;Interview;Knowledge;Learning;lens;long-standing disparities;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Medicaid;Medicaid eligibility;Medicare;Methods;Modeling;multilevel analysis;Non-Small-Cell Lung Carcinoma;novel;Outcome;Patient-Focused Outcomes;Patients;Policies;Politics;population health;Population Study;Provider;Public Health;public policy on tobacco;Quality of Care;Race;racial disparity;Racial Equity;Research;Resources;Sampling;segregation;social;Social Environment;social factors;social health determinants;Social Workers;socioeconomic disparity;Socioeconomic Factors;socioeconomics;Structural Racism;Structure;Supportive care;System;treatment disparity;United States;United States National Institutes of Health;Variant;World Health Organization

PROJECT_TITLE: Health System and Contextual Factors Associated with Racial Equity in Lung Cancer Care

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE This research focuses on extended family caregivers (i.e., grandchildren, siblings, nieces/nephews, step-kin) experiences with home and community-based services to assist with the care of older relatives with Alzheimer's disease and other forms of dementia. Its purpose is to gain an understanding of how extended family caregivers manage their care responsibilities, the informal support and formal services they use to meet the needs of their care recipients as well as to sustain their own well-being. Findings will extend scientific knowledge about informal caregiving beyond what has emerged from the extensive literature focused on spouse and adult children caregivers and provide new and highly relevant information for community services and programs designed to support family dementia care.

PI_NAMEs: ROBERTO, KAREN A (contact);SAVLA, JYOTI S

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adult;Adult Children;Age;Aging;Alzheimer's Disease;Attention;Birth Rate;care coordination;care recipients;Caregiver well-being;Caregivers;caregiving;Caring;Characteristics;Child;Civil Rights;Clinic;Communities;community based service;Community Services;Conceptions;Data Analyses;Dementia;dementia care;dementia caregiving;design;diaries;Divorce;effectiveness evaluation;Emotional;Enabling Factors;Exclusion;experience;Extended Family;Face;Family;Family Caregiver;Family member;family structure;family support;Future;gender equity;grandchild;Health;Health behavior;high risk;Home;Imprisonment;improved;Income;Individual;informal caregiving;informal support;insight;Interview;Investigation;Knowledge;Laws;Learning;Legal;Life;Life Cycle Stages;Link;Literature;Longevity;Managed Care;Marriage;Measures;Methods;middle age;Modeling;Nuclear Family;older adult;Older Population;Outcome;Personal Satisfaction;Persons;Policies;primary caregiver;programs;Quality of life;Race;Recording of previous events;Research;Research Personnel;response;Role;Sample Size;Scientific Advances and Accomplishments;service utilization;Services;sex;Siblings;social movement;Social Problems;Social Welfare;Spouses;stressor;Structure;Techniques;Telephone Interviews;Time;trend;Virginia

PROJECT_TITLE: Persons with Dementia and their Extended Family Caregivers: Service Use, Barriers and Needs


ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Habitual consumption of a high-fat diet is a risk factor for diabetes and cardiovascular disease. Eating a fat-rich meal triggers a surge in blood lipids and inflammatory cells that can last for several hours. We aim to understand why a fatty meal has different effects in males and females, which may inform about the optimal preventive and therapeutic measures that should be taken for cardiometabolic disease in men and women.

PI_NAMEs: REUE, KAREN  (contact);ZHANG, PEIXIANG

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: absorption;age group;Animals;Appearance;Bacteria;biological sex;blood lipid;Bone Marrow Cells;Cardiometabolic Disease;Cardiovascular Diseases;Cells;Ceramides;Chromosomes;Circulation;Consumption;Country;Data;Development;Diabetes Mellitus;Diet;Eating;Endotoxemia;Endotoxins;Estradiol;Ethnic Population;experience;Fasting;Fatty acid glycerol esters;Fatty Liver;feeding;Female;Four Core Genotypes;Gene Expression;genotypic sex;Gnotobiotic;Goals;Gonadal Hormones;gut microbiota;High Fat Diet;Hormones;Hour;Human;Hyperlipidemia;Hypertriglyceridemia;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Intake;Intervention;Knowledge;lipid metabolism;lipidomics;Lipids;Lipolysis;Lipopolysaccharides;Lipoproteins;Long-Term Effects;male;Measures;men;Metabolic Diseases;Metabolism;Modeling;Modernization;Molecular;monocyte;mouse model;Mus;novel;obesity risk;Oral;Ovarian;Ovarian hormone;Ovary;Physiological;Ploidies;Preventive;Process;Production;Risk Factors;Role;saturated fat;sex;Sex Bias;Sex Chromosomes;Sex Differences;Societies;Sphingomyelins;Testicular Hormones;Testing;Testis;Testosterone;Therapeutic;Time;Tissues;trait;Triglycerides;uptake;western diet;Woman;women versus men;Y Chromosome

PROJECT_TITLE: Sex Differences in Postprandial Lipid Metabolism

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: PROJECT NARRATIVE Vascular calcification is the pathological deposition of minerals in the walls of the blood vessels, leading to the hardening and increased stiffness of arterial walls, and increased cardiovascular morbidity and mortality. In this proposal, we aim to define the effects of endothelial cells from the adventitia, the outmost layer of the blood vessels, on the development and progression of atherosclerotic calcification, and identify the unique molecular signature of these adventitial endothelial cells. The completion of the proposed studies may pave the way to develop novel therapeutic strategies to selectively target these endothelial cells, thereby attenuating atherosclerotic calcification.

PI_NAMEs: CAI, XINJIANG  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Age Years;angiogenesis;Animal Model;Aorta;Apolipoprotein E;Arterial Fatty Streak;arterial stiffness;Arteries;Atherosclerosis;biomineralization;Blood Vessels;bone;Bone Development;calcification;cardiovascular risk factor;Cardiovascular system;career;career development;Cartilage;Cell Line;Cellular biology;Chondrocytes;Data;Deposition;Development;Development Plans;Disease;Endothelial Cells;endothelial-specific sialomucin;Endothelium;Exhibits;Fluorescence Microscopy;Foundations;Gene Expression;Gene Expression Profile;Gene Targeting;Genetic Markers;Glycoproteins;Human;insight;K-Series Research Career Programs;Knock-out;Knockout Mice;Knowledge;Light;matrix Gla protein;Medical;Mentors;Mesenchymal;microCT;microscopic imaging;Minerals;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Mus;notch protein;NOTCH1 gene;novel;novel therapeutic intervention;Osteogenesis;osteogenic;osteoprogenitor cell;Pathologic;Pathologic Processes;Pathology;Patients;Pattern;PECAM1 gene;Phenotype;Physicians;Population;prevent;receptor;Regulation;Reporting;Research;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;stem cells;Supporting Cell;Therapeutic;transcriptome sequencing;Tunica Adventitia;Vascular calcification;vascular contributions;Vascular Diseases;Vascular Endothelial Cell

PROJECT_TITLE: Regulation of Vascular Calcification by Adventitial Endothelial Cells

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Most small molecule pharmaceuticals contain multifunctionalized arene rings. Despite their prevalence in medicinally relevant molecules, it is challenges to synthesize these decorated arene rings in one step. This proposal aims to solve this problem through development of new aryne precursors, introduction of transition metal catalysts to solve problems with selectivity, and expansion of the scope of available aryne difunctionalization reactions.

PI_NAMEs: ROBERTS, COURTNEY C (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Binding;Catalysis;catalyst;Chemistry;Coupling;Development;functional group;Goals;Ligands;Medical;Medicine;Methods;Pharmaceutical Chemistry;Pharmacologic Substance;Positioning Attribute;Prevalence;Problem Solving;Reaction;Route;Site;small molecule;Transition Elements

PROJECT_TITLE: Methods for Selective Functionalization of (Hetero)arene Rings


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Autophagy of the endoplasmic reticulum (ER), called ER-phagy, is a selective autophagy pathway that clears misfolded aggregation-prone proteins from the ER to prevent their aggregation. Several ER shaping proteins linked to neurodegenerative diseases, including hereditary spastic paraplegias (HSP), are required for ER-phagy. This proposal addresses how sites of ER autophagy are formed on the ER and the relationship that ER structure has to the formation of these sites and to HSP.

PI_NAMEs: FERRO-NOVICK, SUSAN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Applications Grants;Autophagocytosis;Autophagosome;Binding;Binding Proteins;Biochemical;Cell Survival;cell type;Cells;Cellular Stress;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Complex;COPII-Coated Vesicles;Data;Defect;Degradation Pathway;design;Endoplasmic Reticulum;endoplasmic reticulum stress;experimental study;Golgi Apparatus;Hereditary Spastic Paraplegia;Homologous Gene;Human;Image;imaging study;inhibitor;Knock-out;Lead;Link;link protein;live cell imaging;Mammalian Cell;Mammals;Mass Spectrum Analysis;Mediating;Medical;Membrane;misfolded protein;Mutation;Neurodegenerative Disorders;Neuropathy;overexpression;Pathway interactions;Play;Polymers;prevent;protein folding;Protein Isoforms;Proteins;Publishing;Quality Control;receptor;receptor binding;Reporter;Reporting;Resistance;response;Role;Scaffolding Protein;Shapes;Site;spectroscopic imaging;Structure;trafficking;Vesicle;Work;Yeasts

PROJECT_TITLE: The connection between ER-phagy, ER structure and hereditary spastic paraplegias

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PUBLIC HEALTH NARRATIVE Cognitive impairment, Alzheimer's disease and related dementias have devastating consequences for affected individuals and their families, and despite no clear ways to prevent or treat them at this time, there is increasing evidence that certain lifestyle and health-related risk factors during midlife are likely determinants of cognitive function in later life. Our MidCog study will investigate modifiable, psychosocial factors during middle age that are under-studied in cognitive aging research (e.g. health literacy, self-management capacity, health activation), but may be effective levers for optimizing personal health and self-care, promoting appropriate healthcare use, preventing chronic conditions, improving treatment adherence and ultimately preserving later cognitive function.

PI_NAMEs: WOLF, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Abbreviations;Adult;Affect;Age;age group;Alcohol consumption;Alzheimer's disease related dementia;Anxiety;anxious;Attention;Automobile Driving;Behavior;Behavioral;Biological;caregiving;Caring;Chronic;Chronic Disease;Clinical;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive testing;cohort;Cohort Studies;comorbidity;Complement;Cross-Sectional Studies;Data;dementia risk;Depressed mood;Detection;Diabetes Mellitus;Disease Outcome;Economics;Education;Electronic Health Record;Family;follow-up;Health;health assessment;Health behavior;health knowledge;health literacy;health management;Health Promotion;health service use;Health Status;Health system;Healthcare;Hearing;Heavy Drinking;Hospitalization;human old age (65+);Hyperlipidemia;Hypertension;Impaired cognition;Impairment;improved;Individual;Interview;Investigation;Knowledge;late life;Life Style;Longitudinal cohort;low health literacy;Mediating;Medical;Memory;Mental Depression;Methods;middle age;mortality risk;multiple chronic conditions;novel;Obesity;older adult;Outcome;Participant;Perimenopause;Pharmaceutical Preparations;Pharmacy facility;physical inactivity;poor health outcome;poor sleep;preservation;prevent;psychologic;psychosocial;Psychosocial Factor;psychosocial stressors;Public Health;racial diversity;Recommendation;recruit;Reporting;Research;Risk;Risk Behaviors;Risk Factors;Risk Reduction;Role;Sampling;Sampling Studies;Self Care;Self Management;Sensory impairment;Site;skills;Smoke;Smoking;social;Social support;Socioeconomic Status;Stress;Surveys;Thinking;Time;treatment adherence;Uncertainty;Unhealthy Diet;unhealthy lifestyle;uptake;Vision;Woman;Work

PROJECT_TITLE: Health Literacy and Cognitive Function among Middle-Aged Adults: The MidCog Study

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Mal de Débarquement Syndrome (MdDS) is a rare and under-recognized disorder that in most cases occurs after exposure to prolonged passive motion, but it is nevertheless counted among the most common balance disorders. Despite the overall improvement in MdDS outcomes since the recent discovery of the treatment method based on readaptation of the vestibulo-ocular reflex, substantially many patients do not benefit from this method. This project aims to further advance MdDS intervention by improving access to treatment with a portable device and by targeting physical and visual motion sensitivities as well as a subtype symptomatology of falsely sensed gravitational pull.

PI_NAMEs: YAKUSHIN, SERGEI  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Address;Affective;Aftercare;Back;Chronic;Chronic Disease;Clinical;clinical practice;Cognitive;Complementary therapies;Controlled Study;cost;Coupled;Custom;Data;Dedications;desensitization;design;Devices;Disease;Disorientation;Dizziness;efficacy evaluation;efficacy testing;equilibration disorder;Esthesia;experience;Exposure to;follow-up;Follow-Up Studies;Force of Gravity;Foundations;Frequencies;habituation;Head;Health Services Accessibility;Home;Hour;Improve Access;improved;improved outcome;Intervention;Laboratories;Medial;Methods;Motion;motion sensitivity;Motion Sickness;Movement;New York City;Outcome;patient screening;Patients;Photic Stimulation;Physiological;pilot test;Placebos;portability;Predisposition;Protocols documentation;Randomized;recruit;Recurrence;reduce symptoms;Reporting;Self Perception;Shapes;Side;Signs and Symptoms;Space Perception;success;symptomatic improvement;symptomatology;Symptoms;Syndrome;Telemedicine;Testing;Transportation;Travel;Treatment Effectiveness;Treatment outcome;Treatment Protocols;vestibular system;vestibulo-ocular reflex;virtual reality;virtual reality headset;Vision;Visual;Visual Fields;Visual Motion;visual stimulus

PROJECT_TITLE: Developing robust treatment options for Mal de Débarquement Syndrome

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Brain Disorders;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE This project will generate analytical tools to address three major public health challenges: 1) Tuberculosis, 2) Substance use disorders, and 3) SARS CoV-2. These tools will improve our understanding of the transmission patterns of these diseases, advance our ability to monitor them, and inform intervention strategies. We will build infrastructure to make these methods available to public health practitioners and other researchers.

PI_NAMEs: WHITE, LAURA FORSBERG (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Address;analytical tool;Area;Award;Cessation of life;Collaborations;Communicable Diseases;Communication;Data;Data Set;Databases;Disease;disease transmission;efficacy evaluation;Emerging Technologies;experience;High-Throughput Nucleotide Sequencing;HIV/AIDS;Hot Spot;improved;Incidence;Infrastructure;innovation;Intervention;Link;Machine Learning;mathematical model;Methodology;Methods;Modeling;Monitor;mortality;pandemic disease;Pattern;Positioning Attribute;programs;Public Health;Public Health Practice;Reproducibility;Research;Research Personnel;Risk;SARS-CoV-2 transmission;skills;Statistical Models;Substance Use Disorder;synergism;tool;transmission process;Treatment Efficacy;Tuberculosis;United States;Work

PROJECT_TITLE: Maximizing Investigators' Research Award (R35)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: NARRATIVE This project explores the structural-molecular basis of communication between enzymes catalyzing consecutive chemical reactions in proline metabolism. These enzymes are increasing recognized for their roles in cancer and the virulence of pathogens, and mutations in proline metabolic genes cause numerous hereditary diseases. Understanding how the activities of proline metabolic enzymes are coordinated enriches our understanding of complex enzyme mechanisms and the multifaceted roles of proline metabolism in human health and disease.

PI_NAMEs: BECKER, DONALD F;TANNER, JOHN J (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: 3-Dimensional;Active Sites;Address;aldehyde dehydrogenases;Architecture;bacterial fitness;Binding;Biological Process;Biophysics;carboxylate;Catabolism;Cells;Cellular Structures;chemical reaction;Communication;Cryoelectron Microscopy;Crystallography;Data;Deposition;Development;Disease;electron density;Electrons;Enzymatic Biochemistry;enzyme mechanism;Enzymes;Evolution;experimental study;Flavins;flexibility;Funding;Genes;Glutamates;Goals;Health;Hereditary Disease;Human;Hydrolysis;Infection;Inherited;Insecta;Ions;Kinetics;Knowledge;Larva;Length;Malignant Neoplasms;Mediating;member;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Molecular;Molecular Conformation;Multienzyme Complexes;mutant;Mutation;Nature;Nematoda;novel;Organism;Output;oxidation;Oxidation-Reduction;Oxidoreductase;pathogen;Pathogenesis;Pathway interactions;Phase;Phenotype;Physiological;Play;Productivity;Proline;Proline Dehydrogenase;proline permease;protective pathway;Protein Conformation;protein protein interaction;Proteins;Publications;pyrroline;Regulon;Request for Applications;Research;Resolution;Roentgen Rays;Role;Side;Signal Transduction;Signaling Molecule;Site;structural biology;Structure;symbiont;System;Time;Transcription Repressor;Virulence;Xenorhabdus luminescens

PROJECT_TITLE: Substrate Channeling and Communication in Proline Metabolic Enzymes


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE  The establishment and maintenance of healthy cells and tissues relies on the timely transport of numerous cellular factors to their respective subcellular destinations. Highly regulated molecular motors, such as cytoplasmic dynein, ensure the appropriate delivery of such cargoes such that the final destination matches the needs of the cell. The goal of our research program is to understand how dynein is regulated with a high degree of spatial and temporal precision to ensure that inappropriate transport, which is causative of various human diseases, does not occur.

PI_NAMEs: MARKUS, STEVEN M (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;Architecture;Biological;Cell Cycle;Cell Cycle Stage;Cell Differentiation process;Cell division;Cell membrane;cell type;Cells;Cortical Malformation;Cytoplasm;Defect;Destinations;Development;Disease;Disparate;Dynein ATPase;effective therapy;Ensure;Environment;Goals;Health;Homeostasis;human disease;In Vitro;insight;Life;LIS1 protein;lissencephaly;Maintenance;Mediating;Membrane;Microtubules;Mitotic spindle;Molecular;Molecular Motors;Motor;Motor Neuron Disease;Movement;neuronal cell body;Organ;Organelles;Organism;Play;Positioning Attribute;prevent;Process;programs;Proteins;Regulation;Research;Role;stem cell division;stem cells;Stratification;Tissues

PROJECT_TITLE: Regulation of Dynein-Mediated Transport

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The objective of this proposal is to bring nanopore sequencing technology to its fullest potential. With funding through this program, our group has developed core technologies that are now involved in industrial nanopore sequencing implementation. To be valuable in health care applications the base calling accuracy of nanopore sequencing must be continually improved. We propose several transformative improvements to nanopore sequencing that will increase the base calling accuracy to 99% and which will make nanopore sequencing more inexpensive.

PI_NAMEs: GUNDLACH, JENS  (contact);LASZLO, ANDREW

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Academia;Algorithms;base;Base Sequence;clinical application;Complex;constriction;cost;Creativeness;Dependence;design;Detection;Development;DNA;DNA sequencing;Engineering;Enzyme Kinetics;Enzymes;Epigenetic Process;flexibility;Funding;Gene Duplication;Genomic DNA;Goals;Healthcare;helicase;Hybrids;improved;Industrialization;Industry;innovation;Ions;Kinetics;Laboratories;Length;Maps;markov model;Measures;Methods;Modality;Modification;Molecular Motors;Motion;Motivation;Motor;motor behavior;Movement;mutant;Mutation;Mycobacterium smegmatis;nanoengineering;nanopore;National Human Genome Research Institute;neural network;novel;Nucleic Acids;nucleobase;Nucleotides;physical separation;Play;Point Mutation;Polymerase;portability;prevent;Principal Investigator;Probability;Program Description;programs;Proteins;Reader;Research;Research Personnel;Resolution;RNA;RNA Splicing;Role;Running;Sampling;sequencing platform;Side;Signal Transduction;single molecule;Specificity;success;System;Techniques;Technology;Testing;Time;tool;VDAC1 gene;Vertebral column;voltage;Walking;Work

PROJECT_TITLE: High Accuracy Nanopore Sequencing.


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MACON

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: PROJECT NARRATIVE  Cocaine abuse and dependence remains a health problem in the United States; however, its pathophysiology is not clear, and treatments are inadequate. In order to develop treatments for cocaine use disorder that are effective and minimize side effects, an understanding of alterations that only occur in brain cells associated with cocaine seeking memories and not in brain cells responsible for other behaviors must be made. This career development application serves as both a training tool for the applicant (Dr. Gheidi) and an original research plan that addresses the critical need to explore treatments for cocaine use disorder.

PI_NAMEs: GHEIDI, ALI  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Ablation;Abstinence;addiction;Address;Affect;Alcohols;Anatomy;Anxiety;Applications Grants;Area;Attenuated;Basic Science;Behavior;Behavioral;beta-Galactosidase;Brain;brain cell;career;career development;Career Mobility;cell type;Clinical;clinical care;Clinical Sciences;Cocaine;Cocaine Abuse;Cocaine Dependence;cocaine exposure;cocaine relapse;cocaine relapse prevention;cocaine related behaviors;cocaine seeking;cocaine use;Cocaine use disorder;Code;Cues;Data;Dedications;designer receptors exclusively activated by designer drugs;Development;Dopamine-beta-monooxygenase;Drug abuse;Drug Addiction;Drug Controls;Drug Modelings;drug relapse;DSP 4;Educational workshop;effective therapy;Event;experimental group;experimental study;Exposure to;Faculty;Female;Functional disorder;Funding;Genes;Genetic;Genetic Transcription;Goals;Health;Heroin;Human;Immediate-Early Genes;Immunofluorescence Immunologic;innovation;insight;Intravenous;Laboratories;LacZ Genes;Learning;locus ceruleus structure;male;Medial;Mediating;meetings;member;Memory;Mentors;Methods;motivated behavior;neural;Neurobiology;Neuromodulator;Neurons;Neurosciences;Neurotoxins;Nicotine;noradrenergic;Norepinephrine;Nucleus Accumbens;Pharmaceutical Preparations;Positioning Attribute;Prefrontal Cortex;Process;promoter;Publishing;Rat Transgene;Rattus;Recording of previous events;Regulation;Relapse;Research;Research Personnel;Rodent Model;Role;Scientist;Self Administration;side effect;Signal Transduction;Societies;Statistical Data Interpretation;Stress;Substance abuse problem;symposium;targeted treatment;Techniques;Testing;tool;Training;United States;United States National Institutes of Health;Universities;Visit;Visualization;Withdrawal;Work

PROJECT_TITLE: Norepinephrine modulates medial prefrontal cortex neural ensembles that control cocaine seeking behavior

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]