NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative We will develop an undergraduate training program that will provide opportunities for research training and professional development, leading to entrance into a PhD degree program for students from groups that are underrepresented in the biomedical workforce. Our program will develop these students into experienced researchers, with the technical, operational and professional skill sets needed to succeed in graduate school where they will continue training to produce new biomedical knowledge to solve the complex problems of disease and illnesses that adversely affect human health. As these students pursue graduate degrees in biomedical research, our program will enhance the diversity of the biomedical research workforce.

PI_NAMEs: KING, ELIZABETH GRIEP (contact);SCHULZ, DAVID J

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: apprenticeship;Biomedical Research;career;CCL7 gene;cohort;Communication;Communities;disabled students;Doctor of Philosophy;Eligibility Determination;Ethnic Origin;graduate school;interest;Literature;Low income;Manuscripts;matriculation;Mentors;Methods;Mission;Missouri;programs;racial diversity;Reproducibility;Research;Research Proposals;responsible research conduct;satisfaction;Science;Scientist;Self Efficacy;skills;student training;Students;success;symposium;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: MARC at the University of Missouri-Columbia

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: RAMALINGAM, SURESH S (contact)

PROJECT_TERMS: Acceleration;Achievement;Administrator;anti-cancer research;Award;Basic Cancer Research;Cancer Center;Cancer Center Support Grant;cancer research center director;Cancer Research Project;Catchment Area;Charge;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;community engagement;Community Outreach;Country;Critiques;Decision Making;Development;Ensure;equity, diversity, and inclusion;Evaluation;experience;Fostering;Funding;Goals;Grant;Growth;improved;Infrastructure;innovation;Intervention;Investments;Journals;Leadership;Lung;Malignant Neoplasms;member;Mission;Monitor;Multiple Myeloma;NCI-Designated Cancer Center;operation;pandemic disease;participant enrollment;Persons;Population Research;Positioning Attribute;Process;programs;Publications;recruit;Reporting;Research;Research Personnel;Resource Sharing;Resources;Science;Strategic Planning;Training and Education;Translating;treatment trial;Trust;tumor immunology;Universities

PROJECT_TITLE: Leadership, Planning and Evaluation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Physical Activity;Prevention;Women's Health Research

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Reducing sedentary behavior is a new strategy that may improve cardiovascular health among young women, a group recently identify as having accelerated, sex-specific cardiovascular risk development that is even higher when the woman has experienced an adverse pregnancy outcome. This project seeks to thoroughly and efficiently investigate relationships between sedentary behavior and all-day activity patterns with ideal cardiovascular health components (blood pressure, body mass index, cholesterol, and glucose) by conducting an ancillary study set within an existing longitudinal cohort of more than 4,000 young women (i.e., Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be Heart Health Study [nuMoM2b HHS]). By adding gold standard sedentary behavior measurement, using emerging statistical methods in physical activity epidemiology, and adding measurement of subclinical cardiovascular mechanisms that could link sedentary behavior to cardiovascular disease outcomes, this study has high potential impact to inform novel behavioral interventions that may reduce cardiovascular risk development among young women.

PI_NAMEs: BARONE GIBBS, BETHANY  (contact)

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Acceleration;Accelerometer;Activity Cycles;Acute;Address;Adverse event;adverse pregnancy outcome;Age;Ancillary Study;arterial stiffness;Autonomic Dysfunction;Behavior;Behavior assessment;behavior measurement;Behavior Therapy;Behavioral;Blood Pressure;blood pressure elevation;Body mass index;Calibration;Cardiac health;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cholesterol;Clinical;clinical development;critical period;Data;design;Development;Disease Outcome;Epidemiology;Exposure to;fasting glucose;Glucose;Guidelines;heart rate variability;high risk;high risk population;High Risk Woman;improved;Indiana;innovation;Intervention;Laboratories;Leisures;Life Style;light intensity;Link;Lipids;Longitudinal cohort;Measurement;Measures;men;middle age;Modality;modifiable risk;Monitor;Mothers;Nature;novel;novel strategies;Nulliparity;Outcome Study;Patient Self-Report;Pattern;Persons;Physical activity;Physiologic pulse;post pregnancy;Posture;Pregnancy;Pregnancy Outcome;prospective;Recommendation;Recording of previous events;Reporting;Research;Resources;response;Risk;Risk Factors;Role;sedentary lifestyle;Self Correction;sex;Sex Differences;standard measure;Statistical Methods;Sum;Testing;therapy development;Thigh structure;Time;United States National Institutes of Health;vigorous intensity;Woman;Women's cohort;women's prevention;young adult;young woman

PROJECT_TITLE: Sedentary Behavior and Cardiovascular Health in Young Women

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Advances in precision medicine are making it increasingly possible to tailor healthcare decisions based on the individual patient’s genomic risk profile. However, large-scale validation studies of risk prediction accuracy and its clinical utility are severely lacking in diverse populations. The goal of this eMERGE-IV project is to leverage genetic and electronic health record data for diverse populations to design, optimize, validate and test the clinical utility of ancestry-tailored polygenic risk scores for common diseases of high public health impact.

PI_NAMEs: CHUNG, WENDY K;HRIPCSAK, GEORGE M;KIRYLUK, KRZYSZTOF ;WENG, CHUNHUA  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;All of Us Research Program;Behavior;Biomedical Research;Chronic Disease;Clinical;Clinical Data;Clinical Management;Clinical Research;clinical research site;clinical risk;Collaborations;Colon Carcinoma;Communication;Communities;community engagement;Complex;Coronary Arteriosclerosis;Cost Analysis;cost effectiveness;Data;data modeling;data sharing;design;Development;Diagnostic;discrete data;Disease;diverse data;Educational Models;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;Engineering;Ensure;ethical, legal, and social implication;ethnic diversity;Ethnic Population;European;European ancestry;experience;Extensible Markup Language;Family;Focus Groups;Funding;Genetic;Genetic Risk;genetic risk assessment;Genetic Structures;genetic testing;genetic variant;genome wide association study;genome-wide;genomic data;Genomic medicine;genomic predictors;Genomics;Goals;Health;health disparity;Health Status;Height;high risk;Hospitals;improved;Individual;individual patient;Informatics;Institutional Review Boards;interoperability;Kidney;Knowledge;Link;literacy;Malignant Breast Neoplasm;mathematical ability;Measures;Medical center;Medical Genetics;medical specialties;medically underserved;member;Methods;National Center for Advancing Translational Sciences;Natural Language Processing;New York City;Participant;patient oriented;Patient Preferences;Patient Recruitments;Patients;Performance;Phenotype;phenotyping algorithm;Plug-in;polygenic risk score;Population Heterogeneity;portability;Positioning Attribute;precision medicine;Precision Medicine Initiative;Prevention strategy;Primary Prevention;programs;prospective;Provider;Public Health;public health relevance;racial diversity;racial population;Randomized, Controlled Trials;rare variant;Recommendation;Recording of previous events;recruit;Reporting;Reproducibility;Research;Risk;Risk Assessment;Risk Estimate;Risk Factors;Risk Management;risk perception;risk prediction;Risk Reduction;screening;socioeconomics;Stratification;Structure;Systems Biology;tailored health care;Technology;Testing;Text;tool;trait;trial design;underserved community;Universities;user centered design;validation studies;Variant;Washington

PROJECT_TITLE: EHR-based Genomic Risk Assessment and Management for Diverse Populations


NIH_SPENDING_CATS: Cancer;Comparative Effectiveness Research;Patient Safety

PI_NAMEs: HARVEY, R. DONALD (contact)

PROJECT_TERMS: Adult;Adverse event;authority;Awareness;black patient;Black race;Cancer Center Support Grant;Cancer Patient;cancer site;cancer therapy;Cancer Therapy Evaluation Program;Catchment Area;Childhood;Clinical Data;clinical infrastructure;Clinical Management;Clinical Nursing Research;Clinical Protocols;Clinical Research;clinical translation;Clinical Trials;Clinical Trials Network;Competence;Conduct Clinical Trials;Continuing Education;Data;Data Analyses;Data Collection;data management;Development;Doctor of Pharmacy;Doctor of Philosophy;Documentation;Education;Electronics;Enrollment;Ensure;Ethics;experience;Faculty;falls;Funding;Generations;Goals;Guidelines;improved;Industry;Infrastructure;innovation;Institution;Intervention;Investigational Therapies;Laboratory Research;Leadership;Malignant Neoplasms;Measures;member;Modality;Monitor;National Clinical Trials Network;novel;operation;outreach;pandemic disease;Patients;Peer Review;Performance;Persons;phase I trial;Physician Executives;Physicians;programs;Protocol Compliance;Protocols documentation;recruit;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Safety;Site;Specialist;Structure;System;Therapeutic Clinical Trial;Therapeutic Trials;Time;Training;Training and Education;Translations;treatment trial;Underrepresented Populations;Universities;working group

PROJECT_TITLE: Clinical Protocol and Data Management


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Public Health Relevance Statement: The Administrative Core (Admin Core) is developed to serve as the central point of contact for all matters of the P01, including, but not limited to, scientific and financial operations, preparing progress reports, organizing program retreats, data dissemination, etc. This will be accomplished by a team of experienced investigators and administrators.

PI_NAMEs: SHEN, ZHIYUAN  (contact)

PROJECT_TERMS: Administrative Efficiency;Administrator;Advisory Committees;Biometry;Board Certification;Clinical;Communication;Communities;Complex;data dissemination;Decision Making;Ensure;Environment;experience;federal policy;Fostering;General Population;Goals;high standard;Human Resources;Individual;Institution;Leadership;member;operation;Organization administrative structures;Pathologic;Pathologist;Pathology;Police;Productivity;Program Research Project Grants;programs;Progress Reports;public health relevance;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;sound;statistics;Structure;treatment response;tumorigenesis;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE African trypanosomes are parasites that infect humans and cause the fatal blood-borne disease known as sleeping sickness. Parasite survival and its ability to infect humans depends on two key enzymes that modify the structural organization of DNA, thereby impacting gene regulation of the parasite. Our research will advance our mechanistic understanding of how these critical enzymes control essential biological processes in trypanosomes, potentially leading to the development of inhibitor drugs that can be used to treat and/or cure sleeping sickness and related diseases caused by tropical parasites.

PI_NAMEs: DEBLER, ERIK  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Address;Affect;African;African Trypanosomiasis;Antigenic Variation;Area;Biochemical;Biological;Biological Assay;Biological Process;Biology;Cell Cycle;Cell Cycle Deregulation;Cell Cycle Progression;Cell Cycle Regulation;Cells;Chagas Disease;Chromatin;chromatin protein;combat;Complex;Cryoelectron Microscopy;Data;Defense Mechanisms;Development;Disease;DNA;DNA Binding;DNA biosynthesis;DNA replication fork;drug discovery;effective therapy;Enzymes;Epigenetic Process;epigenetic regulation;Eukaryota;Exhibits;experimental study;Flow Cytometry;fungus;Future;Gene Expression Regulation;Genetic;Genetic Transcription;Genomic DNA;global health;Goals;Histone H3;histone methylation;Histones;Human;Hybrids;Immune system;In Vitro;in vivo;inducible gene expression;inhibitor;inhibitor therapy;insight;interest;Intervention;Kinetoplastida;Knowledge;Leishmania;Leishmaniasis;Life;Lysine;Medical;Methylation;Methyltransferase;Modeling;Modification;Molecular;Monitor;Mutagenesis;mutant;neglected tropical diseases;new therapeutic target;novel;novel strategies;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleosome Core Particle;Nucleosomes;Organism;overexpression;Parasites;Persons;Pharmaceutical Preparations;pharmacologic;Ploidies;Populations at Risk;posttranscriptional;preference;Process;Protozoa;reconstruction;recruit;Regulation;Research;Resistance;RNA;RNA primers;Roentgen Rays;Role;Signal Pathway;spatiotemporal;structural determinants;Structure;System;Testing;Therapeutic;Transcriptional Regulation;Trees;Trypanosoma;Trypanosoma brucei brucei;Trypanosoma cruzi;Variant;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Chromatin Biology of the African Trypanosome

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: This project will determine how mutation of a single ion channel gene causes absence epilepsy by remodeling ion channels that control thalamic cell firing properties. We will explore how a combination of two clinically silent ion channel mutations can summate to create a polygenic model as found in the human disorder, and determine whether it is possible to reverse this disorder by restoring the function of one mutant gene after the clinical appearance of seizures. These findings may lead to novel targets and a gene-guided treatments for childhood epilepsy.

PI_NAMEs: NOEBELS, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Ablation;Absence Epilepsy;Adult;Affect;Appearance;Architecture;Behavior;Brain;Calcium;Calcium Channel;Candidate Disease Gene;Categories;cell type;Cells;Child;Childhood;childhood epilepsy;Clinical;clinically relevant;Cognitive deficits;combinatorial;critical period;Dependence;Development;Disease;Disparate;Electroencephalography;Epilepsy;Epistatic Gene;Equilibrium;Event;excitatory neuron;Exclusion;functional restoration;Future;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Glutamates;Goals;Hereditary Disease;Heterozygote;Homeostasis;Human;Impairment;in vivo;Inherited;inhibitory neuron;Interneurons;Ion Channel;Knock-out;Learning;Link;loss of function mutation;Mediating;Membrane;Messenger RNA;Modeling;Molecular;mouse model;mRNA Expression;mutant;Mutant Strains Mice;Mutation;neural network;Neurons;novel;Onset of illness;patch clamp;Pathogenicity;Pathway interactions;Pattern;Periodicity;Phenotype;postnatal;postsynaptic;presynaptic;programs;Property;Protein Isoforms;Proteins;prototype;Q-Type Calcium Channels;Quantitative Reverse Transcriptase PCR;restoration;Role;Route;Seizures;Synapses;Syndrome;T-Type Calcium Channels;Testing;Thalamic structure;Therapeutic;Time;transcriptome;Variant;vector;virulence gene

PROJECT_TITLE: Excitability and Plasticity of Developing Epileptic Brain


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE (Core-1) The interconnectedness of the projects requires a Core structure to generate the unique set of research tools for the successful and timely execution of the P01 projects. By supporting all of the individual projects of the P01, Core 1 will help advance understanding of the mechanisms of the BRCA network in cancer development and therapy response, which will facilitate rationally designed strategies for cancer prevention and treatment.

PI_NAMEs: XIA, BING  (contact)

PROJECT_TERMS: Address;Alleles;BARD1 gene;base editing;Binding;Biological Process;BRCA1 gene;BRCA2 gene;Breast;Breast Cancer Cell;Breast Cancer cell line;Breeding;cancer prevention;cancer therapy;Cell Line;Cell model;cell type;Cells;Chemoresistance;Chromosome 11;Chromosomes;Complex;CRISPR/Cas technology;Custom;Dedications;Defect;design;Development;Dissection;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Pathway;Embryo;embryonic stem cell;Ensure;ES Cell Line;Evaluation;Fertilization in Vitro;Fibroblasts;Future;gene editing technology;Generations;Genes;Genetic;Genetically Engineered Mouse;genetically modified cells;genome editing;germ free condition;Guidelines;Human;Human Cell Line;Individual;inhibitor;Institution;Knock-out;Knockout Mice;Laboratories;LoxP-flanked allele;Malignant Neoplasms;MCM10 gene;Medulloblastoma;medulloblastoma cell line;Modeling;Modification;Mouse Embryonic Stem Cells;mouse model;Mus;Mutation;novel;Organism;p53-binding protein 1;PALB2 gene;preservation;Process;Production;protein protein interaction;Proteins;rational design;Reagent;recruit;Regulation;replication stress;Research;Research Personnel;Sequence Deletion;Site;Structure;Structure-Activity Relationship;Technology;Testing;tool;treatment response;triple-negative invasive breast carcinoma;tumor progression;tumorigenesis

PROJECT_TITLE: Core 1: Mouse and Cell Modeling


PI_NAMEs: KUDCHADKAR, RAGINI REINEY (contact)

PROJECT_TERMS: Address;Amendment;authority;Bioethics Consultants;Calendar;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Clinical;Clinical Research;Clinical Research Protocols;Clinical Trials;clinically relevant;Collaborations;Committee Members;Committee Membership;community engagement;Community Outreach;Complement;Consultations;COVID-19;Data;demographics;design;Disease;Enrollment;Ensure;Equilibrium;Equity;Ethics;Ethnic Origin;expedited review;Feedback;Fostering;Frequencies;Gender;Goals;Grant;Guidelines;improved;innovation;Institution;Institutional Review Boards;Leadership;Letters;Malignant Neoplasms;medical specialties;meetings;member;Modality;Monitor;Patients;Peer Review;Performance;programs;Protocols documentation;Race;Research;Research Design;Research Proposals;Resources;Review Committee;Risk;Safety;Science;Scientific Evaluation;Services;sound;Surveys;System;Training;treatment trial;Underrepresented Populations;Universities;Update;working group

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Digestive Health Center (DHC) is the Silvio O. Conte Digestive Disease Research Core Center in Cincinnati. The Center aims to support research that yields insight into the causes, pathogenic mechanisms, and new therapies for digestive diseases in children. The DHC advances research by the delivery of state-of-the-art services from Biomedical Cores, a dynamic Enrichment Program of scientific seminars and workshops, and a strong Pilot and Feasibility Program to foster growth of digestive disease research that is relevant to child health.

PI_NAMEs: DENSON, LEE ARMISTEAD (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;analytical tool;Area;Artificial Intelligence;ATAC-seq;Award;base;bench to bedside;biobank;Biological;Biological Assay;Biological Models;Biological Process;Biomedical Research;Breathing;catalyst;Cells;Child;Child Health;Childhood;ChIP-seq;Clinical;Clinical Trials;Collaborations;college;Communities;Computer software;Confocal Microscopy;Data;Development;Diagnosis;diagnostic strategy;Digestive System Disorders;digital imaging;Direct Costs;Discipline;Disease;disease model;DNA;Educational workshop;Environment;Evolution;experimental study;Extramural Activities;Face;Faculty Recruitment;Fostering;Funding;Future;gastrointestinal system;gene correction;Genes;Genetic;Genome;genome editing;Goals;Grant;Growth;Health;human model;Immunity;improved;Infrastructure;innovation;insight;Institution;Interdisciplinary Study;Investments;Journals;Laboratories;Link;Liver diseases;Medical;Medical center;medical specialties;Medicine;Modeling;Molecular;Morphology;Motivation;Names;new technology;novel strategies;novel therapeutics;Organelles;Organoids;Paper;Pathogenicity;Patient Care;Patients;Population;Positioning Attribute;preclinical study;Process;Productivity;programs;Publishing;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;response;Sampling;satisfaction;Services;Signal Transduction;Solid;Source;stem cells;success;symposium;Technology;Tissues;Translational Research;translational study;treatment and outcome;two-photon;Validation;Work

PROJECT_TITLE: Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRITIVE The proposed Physical Genomics Predoctoral Training Program will support the transdisciplinary training in molecular biology, bioengineering, physics, optics, chemistry, and medicine with the goal of providing an understanding of systems and integrative biology in the context of the emerging field of physical genomics.

PI_NAMEs: BACKMAN, VADIM  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Engineering;Genomics;Training Programs

PROJECT_TITLE: Physical Genomics and Engineering Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PHR: NARRATIVE The Genomics Core will assist all four projects, by performing genomics and bioinformatics analyses for this program project. Genomic data generated by this Core will be used to advance our understanding of the role of BRCA network in genome maintenance and cancer.

PI_NAMEs: DE, SUBHAJYOTI  (contact)

PROJECT_TERMS: Address;Adopted;Affect;Aging;analysis pipeline;Architecture;Area;ATAC-seq;Benchmarking;Bioinformatics;bioinformatics pipeline;bioinformatics resource;Biological Models;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;cancer genome;cancer genomics;cancer initiation;ChIP-seq;Chromatin;Chromosomal Rearrangement;chromothripsis;Collaborations;Communities;Complement;Complex;computer framework;Computer software;computerized data processing;Data;Data Analyses;Defect;Development;DNA Damage;DNA Repair;DNA Sequence Alteration;DNA Sequence Rearrangement;Doctor of Philosophy;epigenomics;Etiology;Event;experience;Functional disorder;gene network;Genome;genome integrity;genome resource;genome sequencing;Genomic approach;genomic data;Genomic Instability;genomic profiling;Genomics;Goals;Grant;High-Throughput DNA Sequencing;Human Resources;Hybrids;Impairment;Inherited;innovation;insight;International;Maintenance;Malignant Neoplasms;Mammary Neoplasms;Manuscripts;Maps;Mediating;Molecular Biology;Molecular Conformation;Molecular Target;Mus;Mutagenesis;mutant;Mutation;Nuclear;Nucleotides;Optics;Pathway interactions;Patients;Pattern;Play;Point Mutation;Practice Guidelines;Preparation;Principal Investigator;Process;programs;Publications;repaired;Repetitive Sequence;Reporting;Research Personnel;Role;Scientist;Somatic Mutation;targeted treatment;Technology;transcriptome sequencing;treatment response;tumor;tumor progression;tumorigenesis;whole genome;Work

PROJECT_TITLE: Core 2: Genomics


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative Despite the rapid progress in DNA sequencing, the overwhelming majority of our genome encodes proteins with little or no functional annotation such as the over 1000 proteins that make up the dynamic intracellular organelle, the mitochondria. We will use innovative genetic engineering methods to precisely mutate both mitochondrially encoded and vertebrate-specific nuclear-encoded mitochondrial genes for a rich array of biological, phenotypic and biochemical tests using the zebrafish in this highly collaborative and unique research program. This combination of novel technologies, annotation and genome science will establish scalable new genome science methods and generate important new functional information on the role of mitochondria in biology that, when compromised, underlies disease.

PI_NAMEs: EKKER, STEPHEN CARL (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Aging;Alleles;Animal Model;Animals;Apoptosis;base editing;base editor;Biochemical;Biological;Biological Models;Biological Process;Biology;Body System;Cell Nucleus;Cells;Code;Collaborations;Compensation;design;Development;Disease;DNA sequencing;forward genetics;Functional disorder;functional genomics;Funding;gene product;Generations;Genes;Genetic;genetic approach;Genetic Engineering;Genome;genome annotation;Genome engineering;genome sciences;Genomics;heteroplasmy;Homeostasis;Human;human disease;in vivo;innovation;insight;Knock-in;Knowledge;loss of function;Maintenance;Mediating;Metabolic;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial genome;Mitochondrial Proteins;model organism;Mutagens;Mutate;Mutation;Natural regeneration;new technology;next generation sequencing;novel;Nuclear;Nuclear Proteins;Oligonucleotides;Organ;Organelles;Paper;Pathogenesis;Pathologic Processes;Patients;Phase;Phenotype;Play;Process;programs;Proteins;Proteome;Publishing;Reproducibility;Research;reverse genetics;RNA;Role;Running;Science;screening;Structure;Synteny;System;Technology;Testing;tool;United States National Institutes of Health;Variant;vertebrate genome;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Systematic Vertebrate Functional Genomics

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Digestive Diseases;Pediatric

PROJECT_TERMS: Annual Reports;Area;artificial intelligence algorithm;authority;Authorship;Award;Awareness;base;Belief;bench to bedside;Biomedical Technology;career development;catalyst;Cell Physiology;Child;Childhood;Clinical;Collaborations;college;Confocal Microscopy;COVID-19 pandemic;Development;Digestive System Disorders;digital data;effectiveness evaluation;engineered stem cells;Ensure;Evolution;executive function;Extramural Activities;Fostering;Foundations;Funding;Genes;genome editing;Goals;Health;human stem cells;Immunity;innovation;insight;Institution;Journals;Leadership;Liver diseases;Medical center;medical specialties;Medicine;member;Modeling;Morphology;Names;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Online Systems;operation;Organelles;Organoids;Pathogenicity;Pediatric Hospitals;Pediatrics;Persons;Process;Productivity;programs;Publishing;Recommendation;recruit;Reporting;Research;Research Personnel;Resolution;Resources;response;Schedule;Scientist;Series;service delivery;service utilization;Services;skills;Source;stem cells;Structure;success;Technology;Universities;Work


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative SUDEP is a major cause of death in patients with epilepsy, and in many cases is thought to be due to postictal respiratory depression. Preliminary data support our hypothesis that seizures impair breathing by disrupting function of brainstem serotonin neurons that act as central CO2 chemoreceptors, and that dietary supplementation with milk whey decreases sudden death in epileptic mice by preventing this dysfunction. This proposal seeks to investigate the role of serotonin and chemoreception in SUDEP, and in the protective effect of milk whey, potentially offering a new avenue for preventative treatment of this common co-morbidity of epilepsy.

PI_NAMEs: RICHERSON, GEORGE B (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 5-hydroxy-tryptophan;Aftercare;Age;Amygdaloid structure;Animals;Anticonvulsants;Apnea;Arousal;Body Temperature;Brain;Brain Stem;Breathing;Carbon Dioxide;Cause of Death;Central Sleep Apnea;Cessation of life;Chemoreceptors;common treatment;comorbidity;Data;DBA/1 Mouse;Defect;defined contribution;Diet;dietary;Dietary Supplementation;Drops;Electrocardiogram;Electroencephalography;Epilepsy;experimental study;Frequencies;Functional disorder;Generalized seizures;Genetic;Goals;high risk;Homeostasis;Hour;human model;Hypoventilation;Impairment;in vivo;Incidence;inhibitor;Intractable Epilepsy;Knowledge;Measures;Microdialysis;Milk;Monitor;mouse model;Mus;Mutant Strains Mice;Mutation;neurochemistry;Neurons;optogenetics;Outcome;Patients;Plethysmography;prevent;Prevention;Preventive treatment;protective effect;Respiration Disorders;respiratory;response;Risk;Risk Reduction;Role;SCN8A gene;Seizures;Serotonergic System;Serotonin;sudden cardiac death;Sudden Death;sudden unexpected death in epilepsy;Testing;Tryptophan 5-monooxygenase;ventilation;Ventilatory Depression;Weaning

PROJECT_TITLE: Prevention of SUDEP by milk whey: Role of CO2 chemoreception and serotonin

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Vestibular dysfunction becomes more prevalent with age and contributes significantly to falls in the elderly, but underlying causes are poorly understood. We will study synaptopathy in the vestibular periphery using a combination of electrophysiological, immunohistochemical and behaviorial approaches. Identifying impairments of the vestibular signaling pathway in aging has important implications for developing new therapies for patients with vestibular dysfunction.

PI_NAMEs: PENG, ANTHONY WEI;RENNIE, KATHERINE JANET (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Action Potentials;Address;Adult;afferent nerve;Age;age related;age related changes;age related decline;aged;Aging;aging process;Animal Behavior;Behavior;Behavioral;Brain;Cell Count;Cell Physiology;cell type;Cells;Cochlea;Dendrites;Development;effective therapy;Elderly;electrical property;Electrophysiology (science);Epithelium;equilibration disorder;Equilibrium;Evoked Potentials;Exhibits;experience;falls;Fiber;Functional disorder;Gerbils;Glutamates;Hair;Hair Cells;Head;Head Movements;Human;Immunohistochemistry;Impairment;Laboratories;Labyrinth;mechanotransduction;Mediating;Morphology;Motion;Mus;Nerve Fibers;nerve supply;noise exposure;novel;novel therapeutics;Organ;otoconia;ototoxicity;Patients;Pattern;Performance;Peripheral;Persons;Physiological;Population;Positioning Attribute;postnatal;postsynaptic;Potassium Channel;Preparation;Presbycusis;Presynaptic Terminals;Principal Investigator;Process;Property;receptor;Reflex action;Reporting;response;ribbon synapse;Rodent;Rodent Model;Sensory;Shapes;Signal Pathway;Signal Transduction;Stimulus;Synapses;Synaptic Cleft;Synaptic Transmission;Techniques;Testing;therapy development;transmission process;Type I Hair Cell;Type II Hair Cell;Utricle structure;Vestibular dysfunction;Vestibular epithelia;Vestibular function;Vestibular Hair Cells;vestibular system;virtual;voltage clamp;Work;young adult

PROJECT_TITLE: Aging and Dysfunction in the Peripheral Vestibular System


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Digestive Diseases;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

PI_NAMEs: ARONOW, BRUCE J (contact)

PROJECT_TERMS: Acceleration;Algorithm Design;ATAC-seq;base;bench to bedside;Benchmarking;Bioinformatics;Biological Assay;Body Fluids;Cell surface;Cells;Childhood;ChIP-seq;Clinical Data;cluster computing;college;computational platform;Computational Technique;Computers and Advanced Instrumentation;Consultations;Data;data access;data exploration;data harmonization;data integration;data mining;data quality;Data Set;data sharing;deep sequencing;Deposition;Digestive System Disorders;Disease;E protein;Educational workshop;Ensure;Environment;epigenomics;Evolution;experience;Experimental Designs;experimental study;firewall;Flow Cytometry;Gene Expression;Generations;Genes;Genetic;genetic analysis;genomic data;Genomics;Goals;Health;Hour;human disease;improved;Industry;Infrastructure;Journals;Knowledge;Laboratories;large datasets;Leadership;Link;Medical center;Medicine;member;Metadata;metadata standards;Molecular;Monitor;multiple omics;Output;Pediatric Hospitals;Peer Review;Performance;Positioning Attribute;Process;Productivity;programs;protein expression;Proteins;Protocols documentation;Publications;Publishing;repository;Research;Research Personnel;research study;RNA Splicing;Sampling;Secure;Sequence Analysis;sequencing platform;Series;Services;single cell sequencing;Site;Structure;System;Technology;Tissues;transcriptome sequencing;Universities;Validation;whole genome

PROJECT_TITLE: Gene Analysis Core


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative: How immature cells integrate cell lineage and external signaling information remains a central question in developmental neurobiology whose answers will impact our understanding of disease mechanisms in developmental disorders. This application applies a combination of well- established and cutting-edge molecular genetic tools to test mechanistic models for how the modular domain structure of a core developmental transcription factor, ZNF423, imposes an integration of intrinsic lineage information with multiple extracellular signaling pathways tied to hindbrain malformations.

PI_NAMEs: HAMILTON, BRUCE A (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Animal Genetics;Animal Model;Animals;Architecture;Binding Proteins;Biological Assay;Brain;brain abnormalities;brain malformation;Cell Lineage;Cell model;Cell Proliferation;Cells;Cerebellar vermis structure;Cilia;ciliopathy;Clinical;Complex;CRISPR interference;Cues;Cytoplasmic Granules;Data;Defect;Development;developmental disease;developmental neurobiology;Differentiation Antigens;Disease;Environment;extracellular;Family;Frequencies;Gene Modified;Genes;Genetic;genetic testing;Genetic Transcription;granule cell;Heterozygote;hindbrain;Homozygote;Human;improved;in vivo;Individual;innovation;Intervention;Joubert syndrome;Ligands;malformation;Mediating;Modeling;Molecular Genetics;morphogens;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nephronophthisis;Neuronal Differentiation;notch protein;Nuclear;Organ;Outcome;Pathogenicity;Pathway interactions;Patients;Pattern;Phenotype;Population;precursor cell;progenitor;programs;Proliferating;Proteins;Rare Diseases;Regulator Genes;Reporting;Reproducibility;response;Retinoic Acid Receptor;Role;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cells;Structure;Testing;tool;transcription factor;Transcription Regulatory Protein;Tretinoin;Undifferentiated;Variant;Zinc Fingers

PROJECT_TITLE: Zfp423 Mechanisms in Joubert Syndrome and Related Disorders

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


PI_NAMEs: WIKENHEISER-BROKAMP, KATHRYN ANN (contact)

PROJECT_TERMS: 3-Dimensional;Anatomy;Artificial Intelligence;Award;base;bench to bedside;biobank;Biological Assay;Biological Models;Biological Process;Biopsy;Cell Physiology;Cells;Cellular Structures;Childhood;Collaborations;college;Computers and Advanced Instrumentation;confocal imaging;Confocal Microscopy;Consultations;Cost efficiency;cost efficient;COVID-19 pandemic;COVID-19 testing;Data;Decontamination;design;Digestive System Disorders;digital;Disease;Doctor of Philosophy;Educational workshop;Electron Microscopy;Electrons;empowerment;Ensure;Evolution;experience;Experimental Designs;experimental study;Fluorescence;Foundations;Gastrointestinal tract structure;Genes;Goals;Health;Hour;Human;Human Resources;human tissue;Image;Image Analysis;imaging system;Immune;Infrastructure;Injury;Institution;instrument;instrumentation;Investments;Laboratories;Leadership;Link;live cell microscopy;Liver;man;Medical center;Medicine;Methods;Microscope;Microscopic;microscopic imaging;Microscopy;Molecular Biology;Morphology;multidisciplinary;Mus;Names;new technology;novel;Nucleic Acids;online tutorial;Organelles;Organoids;Output;pandemic disease;pandemic impact;Pathologist;Pathology;Pediatric Hospitals;Peer Review;Phenotype;Physicians;Physiology;Positioning Attribute;Procedures;Process;Productivity;programs;Proteins;Protocols documentation;Publications;Qualifying;quality assurance;Quality Control;Reagent;repaired;Research;Research Personnel;Resolution;Resources;response;Robotics;Safety;Sampling;Schedule;Scientist;Series;service delivery;service utilization;Services;Signal Transduction;Specimen;Stains;Surface;Technology;Technology Transfer;Tissues;Training;Translational Research;two-photon;ultra high resolution;Video Recording;Visualization;web based software;Zebrafish

PROJECT_TITLE: Integrative Morphology Core


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: WELLS, JAMES M (contact)

PROJECT_TERMS: 3-Dimensional;Alagille Syndrome;Alleles;Antral;Autoimmune Hepatitis;base;Basic Science;bench to bedside;Biliary;Biliary Atresia;biobank;Biological Assay;Biological Models;Biotin;CDH1 gene;Cell Line;Cells;Childhood;Cholestasis;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;Colon;Congenital Megacolon;cost;CRISPR interference;CRISPR/Cas technology;Crohn's disease;Cystic Fibrosis;Development;Digestive System Disorders;directed differentiation;Disease;disease mechanisms study;empowerment;Esophagus;Evolution;experience;Foundations;Funding;gastrointestinal;Gastrointestinal Diseases;gastrointestinal system;Gene Modified;Genetic;genome editing;Goals;Health;Homeostasis;Human;human disease;human embryonic development;human induced pluripotent stem cells;human model;human pluripotent stem cell;human subject protection;human tissue;improved;induced pluripotent stem cell;innovation;innovative technologies;Institution;interest;Intestines;Investigation;investigator training;Investments;Knock-in;Knock-out;knockout gene;Label;Laboratories;Leadership;Ligase;Liver;Liver diseases;Malabsorption Syndromes;malignant stomach neoplasm;Mediating;Medical center;Medicine;Methods;Microbe;Mission;Modeling;Names;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;next generation;nonalcoholic steatohepatitis;novel;novel diagnostics;novel therapeutics;Organ;Organoids;Pancreas;Patients;Pediatric Hospitals;Phenotype;Physiology;Pluripotent Stem Cells;Positioning Attribute;Production;Proteins;Protocols documentation;Reporter;Research;Research Personnel;response;Role;Sampling;scale up;screening services;service delivery;Services;Steatohepatitis;stem cell biology;stem cells;Stomach;success;Supervision;System;Technology;Technology Transfer;Testing;Tissues;tool;Training;Translations;United States National Institutes of Health;Universities;Visualization

PROJECT_TITLE: Stem Cell/Organoid and Genome Editing Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PUBLIC HEALTH NARRATIVE As the number of adults over 65 is expected to double by 2050, health systems must urgently seek ways to support the many older adults managing not just one but multiple chronic conditions, while contending with cognitive decline as the result of aging. Our LitCog IV study has the unique ability to elucidate potentially modifiable, causal mechanisms linking cognitive decline and impairment to worse health; with a particular focus on the optimal involvement of caregivers. Findings will directly guide the design of effective health system interventions to support the primary care management of a diverse, older patient population.

PI_NAMEs: WOLF, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Administrative Supplement;Adult;advanced disease;Affect;Age;Aging;Alzheimer's disease related dementia;Award;Behavioral;Caregiver support;Caregivers;Caring;Chicago;Chronic;Chronic Disease;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Cohort Studies;Communities;Complex;Cross-Sectional Studies;Data;Dementia;design;disability;Disease Outcome;disorder control;Education;follow up assessment;follow-up;functional decline;Goals;Health;health assessment;Health behavior;health literacy;Health Services Research;Health Status;Health system;Healthcare;Hearing;Hospitalization;Impaired cognition;Intervention;Interview;Investigation;Link;Managed Care;Mediating;Medical;medication compliance;Mental Health;Morbidity - disease rate;mortality;multiple chronic conditions;older adult;older patient;Outcome;Participant;patient population;Patient-Focused Outcomes;Patients;Personality;Pharmacy facility;physical conditioning;Positioning Attribute;Prevalence;Primary Care;primary care practice;psychologic;Public Health;racial diversity;Records;recruit;Risk;Role;Sampling;Self Care;Self Management;Sensory;Services;skills;social;social determinants;Social isolation;Socioeconomic Status;Technology;Time;treatment adherence;Vision

PROJECT_TITLE: LitCog IV: Health Literacy and Cognitive Function Among Older Adults

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


PI_NAMEs: OLLBERDING, NICHOLAS J (contact)

PROJECT_TERMS: Acceleration;advanced analytics;Affect;Age;Area;Attention;Award;base;Basic Science;bench to bedside;biobank;Biological Process;Biometry;Biopsy;Center for Translational Science Activities;Certification;Child;Childhood;Clinical;clinical care;clinical center;Clinical Research;Clinical Trials;clinically actionable;clinically significant;college;Complex;Consultations;Data;Data Analyses;data infrastructure;data management;data platform;Databases;design;Development;diagnostic strategy;Digestive System Disorders;Disease;disease registry;effective therapy;Ensure;Fostering;Funding;Genomics;Goals;Growth;Health;Hour;Human;human disease;human tissue;Infrastructure;innovation;Institution;Institutional Review Boards;Investigation;Laboratories;Laboratory Research;large datasets;Learning;Medical center;Medicine;Methods;Minority;Monitor;Names;novel therapeutics;Organ;organ injury;Organism;Outcome;Pathogenesis;Patients;Pediatric Hospitals;Phase;Phenotype;Pluripotent Stem Cells;Population;Positioning Attribute;pre-clinical;preclinical study;Race;Registries;Reporting;repository;Research;Research Design;Research Personnel;response;Sample Size;Sampling;Security;Services;Sex Distribution;Statistical Data Interpretation;Stomach;Technology;Therapeutic Intervention;Tissues;tool;Training;Translational Research;Translations;Universities;web portal;Work

PROJECT_TITLE: Clinical-Component


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Projective Narrative: The goal of these studies is to understand how protein folding and other conformational changes are modulated by sequence variation and features in the cellular environment. Experiments are focused on the effect of the ribosome and co-translational protein folding, the effect of post- translational modifications and cellular complexes, and how kinetic barriers, such as those that control the lifetime of a folded protein, are encoded in the sequence and structure.

PI_NAMEs: MARQUSEE, SUSAN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Amino Acid Sequence;Area;biophysical analysis;Biophysics;career;Cells;Cellular Stress;Complex;Crowding;Data;Disease;Environment;experimental study;Free Energy;Goals;Health;In Vitro;in vivo;Kinetics;Link;Modification;Molecular;Molecular Conformation;Mutation;Nature;non-Native;Pathology;Population;Post-Translational Protein Processing;Protein Biosynthesis;protein degradation;Protein Dynamics;protein folding;protein purification;Proteins;proteostasis;Quality Control;Ribosomes;Sampling;Signaling Protein;single molecule;Structural Models;Structure;Technology;Testing;Tube;Variant

PROJECT_TITLE: Sequence and Environmental Determinants of the Protein Energy Landscape

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Childhood Obesity;Chronic Pain;Clinical Research;Diabetes;Neurodegenerative;Neurosciences;Obesity;Pain Research;Pediatric;Peripheral Neuropathy

PHR: PROJECT NARRATIVE Diabetic neuropathy is a painful and debilitating condition that affects 50% of patients with diabetes, and for which limited effective treatments are available. There is increasing evidence that atypical sphingolipids may be contributing to the development of diabetic neuropathy, and that treatment with the amino acid L-serine may reduce the levels of these toxic lipids. The goal of the proposed studies is to determine which sphingolipid molecules are most relevant to diabetic neuropathy and could serve as potential treatment targets for this debilitating and currently untreatable diabetic complication.

PI_NAMEs: FRIDMAN, VERA  (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Alanine;Amino Acids;Animal Model;Animals;Automobile Driving;Biological;Biological Markers;Biology;blood glucose regulation;Case/Control Studies;Clinical;clinical outcome measures;Clinical Research;clinical translation;Clinical Trials;clinically relevant;cohort;Colorado;comparison control;Complex;Complications of Diabetes Mellitus;Data;density;Development;Diabetes Mellitus;Diabetic Neuropathies;Diagnosis;Disabling;Disabling condition;Disease;effective therapy;Endocrinology;Enzymes;Epidemiology;Ethnic Origin;Exclusion;Future;Goals;Grant;Health Services Accessibility;Hereditary Sensory and Autonomic Neuropathies;High Prevalence;Hyperglycemia;improved;Infrastructure;instrument;Intervention;Knowledge;Lipids;Mass Spectrum Analysis;Measures;Mentorship;Metabolic;Metabolism;Michigan;Modeling;Morbid Obesity;nerve conduction study;Nerve Fibers;Neuropathy;neurotoxic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;obese person;Obesity;Oral;oral supplementation;Outcome Measure;Pain;Participant;Pathogenesis;Pathway interactions;Patients;Persons;Plasma;Prevention strategy;professional atmosphere;programs;prospective;Quality of life;Race;rare genetic disorder;Reaction;recruit;Reporting;Research Design;Research Personnel;Rodent Model;Role;Sampling;screening;Serine;serine palmitoyltransferase;Severities;sex;skin biopsy;Sphingolipids;Statistical Methods;Supplementation;Symptoms;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutic target;Thinness;Time;Training;Universities;Visit;Work;Youth

PROJECT_TITLE: Role of Complex Sphingolipids in Diabetic Neuropathy

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


PI_NAMEs: ALENGHAT, THERESA  (contact)

PROJECT_TERMS: Area;Award;base;bench to bedside;Biomedical Research;Budgets;career development;Childhood;Collaborations;college;Communities;Creativeness;Data;Development;Digestive System Disorders;Direct Costs;Eligibility Determination;evidence base;Extramural Activities;Feasibility Studies;Feedback;Fostering;Foundations;Funding;Goals;Grant;Health;Immunity;improved;innovation;Institution;interest;Investments;Leadership;Link;Liver diseases;Medical center;Medicine;member;Mentors;Mentorship;Mission;Modeling;multidisciplinary;Names;novel;Organoids;Outcome;Paper;Patients;Pediatric Hospitals;Pilot Projects;Play;Process;programs;Publications;Publishing;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;Science;stem cells;Study Section;success;System;tool;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Feasibility Program


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE – OVERALL COMPONENT Obesity and its complications and nutrition-related diseases are a major public health problem because of their high prevalence, effect on quality-of-life and economic impact. The NORC will help reduce this burden by enhancing and stimulating cost-effective research in nutrition and obesity that will ultimately lead to improved clinical therapies and effective community interventions.

PI_NAMEs: KLEIN, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Address;adipocyte biology;Adipocytes;Adipose tissue;Allied Health Personnel;Animal Husbandry;Animal Model;Applied Research;Area;Arts;Award;Bariatrics;base;Basic Science;Biochemical;Biomedical Research;Biometry;Blood specimen;Body Composition;Breeding;Cancer Center;Cardiovascular system;career;career development;Cell Line;Cellular biology;Child Health;Clinical;Clinical and Translational Science Awards;clinical application;clinical center;clinical imaging;clinical investigation;Clinical Investigator;Clinical Nutrition;clinical practice;Clinical Research;Clinical Sciences;Collaborations;college;Communication;Community Health;community intervention;Complex;cost effective;Creativeness;Data;design;Development;Diabetes Mellitus;diabetic cardiomyopathy;Digestive System Disorders;Direct Costs;Discipline;Disease;dissemination science;economic impact;Education;Environment;Equipment;Equity;Exercise;extracellular vesicles;Faculty;follower of religion Jewish;Fostering;Functional disorder;Funding;Gene Expression;Genome;Genotype;Goals;Grant;Growth and Development function;gut microbiome;Health;Health behavior;Health Personnel;High Prevalence;Home;Hormones;Hospitals;House Staffs;Human;implementation science;improved;in vivo;Infrastructure;innovation;interdisciplinary approach;Interdisciplinary Study;interest;Intervention Studies;Kinetics;Knowledge;Laboratories;lifestyle intervention;Magnetic Resonance Imaging;mathematical model;medical schools;member;Mentors;Mentorship;metabolic abnormality assessment;metabolic phenotype;metropolitan;Mitochondria;Molecular;Molecular Analysis;Molecular Biology;Morphology;Muscle;Muscle Cells;next generation;nutrient metabolism;nutrition;Nutritional;Nutritional Study;Obesity;obesity prevention;Outcome;outreach;Patient Care;Pediatric Hospitals;Performance;performance tests;Physical Performance;Physicians;Physiology;Plasma;Policies;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;programs;protein expression;Public Health;Quality of life;Research;Research Personnel;Research Support;Research Technics;Research Training;Resources;Sampling;Schools;Science;Services;Source;Spectrum Analysis;stable isotope;Structure;Students;Talents;Therapeutic;Tissue Sample;Tracer;Training;Training and Education;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Washington University Nutrition Obesity Research Center


PI_NAMEs: MIETHKE, ALEXANDER  (contact)

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Nutrition;Obesity;Prevention

PROJECT_TERMS: Abbreviations;Achievement;Administrator;Advisory Committees;Annual Reports;base;Biomedical Research;Biometry;Budgets;Charge;Clinical;Clinical Nutrition;Clinical Research;Clinical Sciences;Collaborations;Communication;cost;Dissemination and Implementation;Elements;Ensure;Faculty;Funding;Goals;Grant;Growth;Guidelines;Hospitals;Human;Interest Group;Journals;Laboratories;Leadership;Measures;medical schools;meetings;Metabolic;Methods;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nutrition;Obesity;Policies;prevent;Principal Investigator;programs;Publications;Recommendation;Research;Research Personnel;Research Project Grants;Schedule;Series;Services;Site;success;Time;Translational Research;United States National Institutes of Health;Universities;Videoconferencing;Washington;web site;Weight maintenance regimen

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: HOSPITALS

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: This research project aims to use the genetically tractable Drosophila model to dissect analgesic signaling- dampening of nociceptive responses. Given the established conservation of genes required for both basic sensory neuronal functions and for nociception and nociceptive sensitization we expect that the findings from a genetic dissection of analgesia in this model will likely be relevant to human health.

PI_NAMEs: GALKO, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Absence of pain sensation;Acids;Acute;Afferent Neurons;Analgesics;Animals;antinociception;Area;base;Basic Science;Behavioral;behavioral response;Binding;Biochemical;Biological;Biological Assay;Biology;Calcium;Candidate Disease Gene;Cells;Chemicals;Clinical;clinical practice;Complement;Constipation;Data;Development;Dissection;Dose;Drosophila genus;endogenous opioids;Exhibits;feeding;Fentanyl;fighting;fly;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;gene conservation;gene discovery;Gene Expression Profiling;gene function;Genes;Genetic;genetic analysis;genetic approach;Goals;Hand;Health;health practice;Human;Image;improved;Injury;Ion Channel;Knowledge;Larva;Ligands;Mechanics;Mediating;Mediator;Modality;model organism;Modeling;Molecular;Morphine;morphine administration;Morphine Receptors;morphine tolerance;Naloxone;Neurons;Neuropeptides;Nociception;nociceptive response;novel;Opioid;Opioid Peptide;Opioid Receptor;Organism;Orthologous Gene;Pain;Pathway interactions;Peptides;Peripheral;Phenotype;Physiological;receptor;receptor binding;Reporter;Research Project Grants;response;Sensory;side effect;Signal Pathway;Signal Transduction;somatostatin receptor 2;Speed;Stimulus;System;Testing;tissue injury;Tissues;tool;Touch sensation;Trauma;Vertebrates;Withdrawal;Work

PROJECT_TITLE: Analgesic Signaling in Drosophila

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


PI_NAMEs: MITTENDORFER, BETTINA  (contact)

PROJECT_TERMS: Abbreviations;Adipose tissue;Animal Model;apolipoprotein B-100;Area;Biochemical Pathway;Bioinformatics;Biometry;Biopsy Specimen;Blood specimen;Body Composition;Body measure procedure;Body Weight decreased;Cardiovascular Physiology;Catheters;Cell Physiology;Cellular biology;Center for Translational Science Activities;Clinical;Clinical and Translational Science Awards;Clinical Nutrition;Clinical Research;Clinical Sciences;clinical translation;Complex;complex data;Consultations;Data;Data Set;design;Diet;Dietary Intervention;Discipline;dissemination science;Dual-Energy X-Ray Absorptiometry;eligible participant;Energy Metabolism;Ensure;Epidemiology;Exercise;exercise training;Glucose;Glucose Clamp;glucose production;Glycerol;Goals;Hepatic;Hormones;Hyperinsulinism;image translation;implementation science;Infusion procedures;Ingestion;Inpatients;Intervention;Intervention Studies;intravenous glucose tolerance test;Kinetics;Laboratories;Leucine;lifestyle intervention;Liquid Chromatography;liquid chromatography mass spectrometry;macromolecule;Mass Fragmentography;Mass Spectrum Analysis;mathematical model;Measures;medical schools;Metabolic;Metabolic Pathway;metabolomics;Modeling;Molecular Biology;Monitor;Muscle;National Center for Advancing Translational Sciences;Nuclear Magnetic Resonance;nutrition;Obesity;operation;organizational structure;Outcome;Outpatients;Palmitates;Participant;Performance;performance tests;Physical Performance;Polysomnography;Positron-Emission Tomography;Procedures;Production;Protocols documentation;radial artery;radiotracer;Research;Research Design;Research Personnel;research study;Sample Size;Sampling;Scientist;Services;Stable Isotope Labeling;Statistical Data Interpretation;tandem mass spectrometry;Testing;Tissue Sample;Tissues;Tracer;Training;Training and Education;Translational Research;Triglycerides;Universities;very low density lipoprotein triglyceride;Washington;Weight Gain

PROJECT_TITLE: Clinical Science Research Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE The goal of this project is to use cutting-edge single-cell RNA sequencing, induced pluripotent stem cell (iPSC), and CRISPR technologies to understand why certain brain regions, certain cell types, and some individual cells within a cell type degenerate earlier and to a great extent in late-onset Alzheimer’s Disease. The findings from this study could uncover novel avenues for the treatment and prevention of Alzheimer’s disease.

PI_NAMEs: HUANG, YADONG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Ablation;Age;Age of Onset;age related neurodegeneration;aged;Aging;Alzheimer associated neurodegeneration;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Biological Models;Brain region;cell type;Cells;Central Nervous System;Cerebellum;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;CRISPR/Cas technology;Data;Data Set;density;Development;Disease Resistance;Disease susceptibility;disorder risk;entorhinal cortex;gene editing technology;genetic risk factor;Genotype;Goals;Hippocampus;Human;human induced pluripotent stem cells;Immune response;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Injury;insight;Knock-in Mouse;Knock-out;Late Onset Alzheimer Disease;Lead;life span;Link;Long-Term Depression;Long-Term Potentiation;Major Histocompatibility Complex;Mediating;Microglia;mild cognitive impairment;Molecular;mouse model;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Population;postsynaptic;Predisposition;prevent;Protein Isoforms;Proteins;Regulation;Research;resilience;Role;Severities;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;single-cell RNA sequencing;Stress;Synapses;Synaptic plasticity;synaptic pruning;synaptogenesis;tau Proteins;Time;tool;Transgenic Mice;Translating;Up-Regulation;Work

PROJECT_TITLE: Neuronal ApoE Drives Selective Neurodegeneration in Alzheimer's Disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Digestive Diseases;Inflammatory Bowel Disease;Microbiome;Nutrition

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: NARRATIVE Dietary sugar is a major risk factor for many non-communicable diseases, including inflammatory bowel disease (IBD). However, how dietary sugar contributes to IBD pathogenesis and how the immune system regulates sugar homeostasis in the gut are poorly understood. This proposed study aims to investigate the role of dietary simple sugar glucose in IBD pathogenesis using animal models and explore an innate immune pathway that protects against intestinal inflammation via regulation of the glucose homeostasis in the gut.

PI_NAMEs: ZAKI, HASAN  (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Animal Model;Bacteria;Bacteroides;blood glucose regulation;CASP1 gene;Clinical Research;Colitis;Complex;Consumption;Country;Coupled;Crohn's disease;cytokine;cytotoxicity;Data;Developed Countries;Development;dextran sulfate sodium induced colitis;Diet;dietary;Dietary Sugars;Disease;Disease susceptibility;Energy-Generating Resources;Epithelial Cells;Epithelium;Etiology;Exhibits;Fatty acid glycerol esters;Fiber;Functional disorder;Gene Expression;Genes;Genetic Predisposition to Disease;Glucose;glucose metabolism;glucose transport;Glucose Transporter;Growth;gut inflammation;gut microbiota;Health;Homeostasis;Host Defense;Human;IL18 gene;Immune;Immune response;Immune system;In Vitro;in vivo;Incidence;Inflammasome;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;innate immune pathways;Innate Immune System;innovation;insight;Insulin Resistance;Intake;intestinal epithelium;intestinal homeostasis;Intestines;Investigation;Link;Long-Term Effects;Maintenance;microbial;microbial community;microbiota;microbiota composition;Molecular;Monitor;Mucolytics;Mucous body substance;Multiprotein Complexes;Mus;novel;Obesity;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Play;Predisposition;Production;protective pathway;Recommendation;Regulation;Risk Factors;Role;Signal Pathway;Signal Transduction;Spontaneous colitis;sugar;symporter;targeted treatment;Testing;Ulcerative Colitis;western diet;Wild Type Mouse

PROJECT_TITLE: The Inflammasome in the Regulation of Intestinal Glucose Homeostasis, Microbiota and Inflammation

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Lung;Lung Cancer;Precision Medicine;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: MISCELLANEOUS

PHR: Project Narrative The objective of this project is to optimize lung cancer screening by selecting individuals for lung cancer screening based on their personal lung cancer risk, and by tailoring screening decisions and diagnostic management of pulmonary nodules to individuals. The anticipated findings of this project will provide individualized screening and diagnostic schedules that will enhance the effectiveness and efficiency of the overall screening program by integrating lung cancer risk and life expectancy. A personalized screening framework will be developed to formalize and facilitate the lung cancer screening decision-making process.

PI_NAMEs: TOUMAZIS, IAKOVOS  (contact)

PROGRAM_OFFICER_NAME: DORIA-ROSE, PAUL P

PROJECT_TERMS: Address;Age;Age Years;Anxiety;Benign;Biopsy;Blood;blood-based biomarker;cancer diagnosis;Cancer Etiology;Cancer Patient;cancer risk;Cessation of life;compare effectiveness;cost;cost effective;cost effectiveness;cost-effectiveness evaluation;Data;Data Management Resources;Decision Making;Decision Modeling;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Procedure;diagnostic strategy;Disease;Dose;Early Diagnosis;Effectiveness;effectiveness evaluation;Eligibility Determination;emotional distress;Ensure;Exclusion;Family;Guidelines;Health Benefit;high risk;Histology;improved;Individual;Intervention;Knowledge;Life Expectancy;low dose computed tomography;Lung;lung cancer prevention;lung cancer screening;Lung CAT Scan;Lung Diseases;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Modality;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality risk;Natural History;Nodule;non-smoking;Patients;personalized diagnostics;personalized management;personalized screening;PET/CT scan;Population;Population Group;Process;programs;psychological distress;Race;Radiation exposure;randomized, clinical trials;Recommendation;Recording of previous events;Relaxation;Reporting;Research;Resources;Risk;Risk Assessment;Risk Factors;risk mitigation;risk prediction model;Schedule;screening;screening guidelines;screening program;Secondary Cancer Prevention;sex;Smoke;Smoker;Smoking;smoking cessation;smoking exposure;Smoking History;Specific qualifier value;standardize guidelines;Testing;Time Management;United States;United States Preventative Services Task Force;Update

PROJECT_TITLE: Optimizing Personalized Screening and Diagnostic Decisions for Lung Cancer Based on Dynamic Risk Assessment and Life Expectancy

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Aging;Clinical Research;Comparative Effectiveness Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH/LUTS) is an extremely common set of conditions among older men, yet conventional pharmacological treatment strategies fail in preventing long-term clinical outcomes in about 30% of treated patients. This project seeks to evaluate the effectiveness of contemporary treatment strategies and use predictive modeling to determine which patients are likely to exhibit long-term BPH/LUTS progression. Given the considerable cost of BPH/LUTS management and impact on the general health and quality of life in older men, identification of effective and personalized pharmacological treatment strategies is critical.

PI_NAMEs: LANGSTON, MARVIN EPOLIAN (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Acceleration;Acute;Address;Adrenergic alpha-Antagonists;Adrenergic Antagonists;Age;Alternative Therapies;Anti-Cholinergics;Asian Americans;associated symptom;Benign;Benign Prostatic Hypertrophy;Big Data;black men;Caring;Cessation of life;Clinical;clinical phenotype;cohort;Combined Modality Therapy;comparative effectiveness;compare effectiveness;Complex;cost;Coupled;Data;Data Set;Deterioration;Diagnosis;Disease Progression;Effectiveness;effectiveness evaluation;electronic data;Electronic Health Record;Epidemiology;ethnic difference;Etiology;Exhibits;experience;Funding;Future;Goals;Grant;Health;Healthcare;High Prevalence;high risk;Hispanic;Histologic;Hyperplasia;improved;Incidence;individualized medicine;inhibitor;innovation;Investigation;K-Series Research Career Programs;Laboratories;lower urinary tract symptoms;Machine Learning;Malignant neoplasm of prostate;member;men;Methodology;Methods;Modality;Muscle relaxation phase;Muscle Tonus;Newly Diagnosed;Nodule;novel;Observational Study;older men;Operative Surgical Procedures;Outcome;Overactive Bladder;Patients;personalized approach;personalized medicine;pharmacologic;Pharmacological Treatment;Phenotype;phosphoric diester hydrolase;Population;Predictive Analytics;Predictive Factor;predictive modeling;Prevalence;prevent;Progressive Disease;Prostate;prostate enlargement;Prostatic Diseases;prostatitis;Quality of life;Race;racial difference;Reporting;Research;Research Design;Risk;risk prediction model;Scientist;Secondary to;skills;Smooth Muscle;Source;Surveys;Symptom Burden;symptom management;Symptoms;Time;tool;Training;Translating;translational scientist;Treatment Effectiveness;Treatment Failure;treatment strategy;Urethra;Urinary Retention;urologic;Urology;Validation;Work

PROJECT_TITLE: Long-term effectiveness of BPH/LUTS pharmacological therapies and using machine learning based predictive analytics to tailor treatment

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS EDUCATION AND RESEARCH ASSOCIATION OF MICHIGAN

ORG_STATE: MI

PHR: Public Health Relevance Falls in older adults are common, have high societal and monetary costs, often lead to injury and can even be fatal. It is known that noise can damage the vestibular periphery resulting in postural instability and compromised balance. This project will investigate how natural aging is accelerated by lifetime noise exposure, and how that can lead to impaired vestibular function, contributing to propensity to fall.

PI_NAMEs: SHANIDZE, NATELA M.;STEWART, COURTNEY ELAINE (contact)

PROJECT_TERMS: Acceleration;Accidents;Acoustics;Address;Adult;Age;age group;age related;age related changes;age related decline;Aging;aging population;Anatomy;Animal Experimentation;Animal Model;Animals;Basic Science;body position;Cells;Cessation of life;Characteristics;Clinic;Clinical;clinical application;Cochlea;cohort;comparison control;Compensation;Control Groups;Detection;Diagnosis;disability;Disease;Dose;Environment;Epithelium;Equilibrium;Evaluation;Exhibits;experimental study;Exposure to;fall risk;falls;Financial cost;Force of Gravity;Frequencies;Functional disorder;functional improvement;Genetic;Goals;Head;Head Movements;Hearing;Human;human old age (65+);Impairment;improved;Individual;Injury;insight;interdisciplinary approach;Investigation;Labyrinth;Life;life span;Link;Maintenance;Measures;Methods;middle age;Modeling;morphological criteria;Morphology;Motion;Motor;motor impairment;Musculoskeletal Equilibrium;neglect;Neurons;Noise;noise exposure;Noise-Induced Hearing Loss;normal aging;older adult;Older Population;Organ;otoconia;Participant;Performance;Physiological;Planet Earth;Play;Population;Posture;posture instability;Predisposition;pressure;Prevention;Proprioception;Psychophysics;public health relevance;Rattus;Recording of previous events;Reflex action;Rehabilitation therapy;response;Risk;Risk Factors;Rodent;Role;Rotation;secondary analysis;Secondary to;Semicircular canal structure;senescence;Sensory;societal costs;sound;Source;Spinal Cord;Structure;Symptoms;Synapses;System;Testing;Training;Translations;treatment strategy;Variant;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular loss;Vestibular Nerve;vestibular reflex;vestibular system;vestibulo-ocular reflex;Vision;Walking

PROJECT_TITLE: Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

PI_NAMEs: ABUMRAD, NADA A. (contact)

PROJECT_TERMS: 5'-AMP-activated protein kinase;Abbreviations;adipocyte biology;Adipocytes;adipokines;Adipose tissue;Animal Model;Animals;base;Basic Science;Biological Assay;Biology;Biopsy;Blood specimen;Blood Vessels;Body System;Brown Fat;CD36 gene;Cell Communication;Cell Fraction;Cell Line;Cell Physiology;Cell Separation;Cells;Cellular biology;Chinese Hamster Ovary Cell;Clinical Investigator;Clinical Research;Clinical Sciences;Comb animal structure;Core Facility;cost;cost effective;cytokine;Data Analyses;Diabetes Mellitus;differentiation protocol;Digestive System Disorders;Embryo;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Equipment;Evaluation;exosome;experience;Extracellular Matrix;extracellular vesicles;Fatty Acids;Fibroblasts;FRAP1 gene;Gene Expression;Gene Proteins;Genome;Glucose;Hepatocyte;Human;Image;Immune;in vivo imaging system;Individual;Infrastructure;inhibitor;Institution;Intake;Kidney;Liver;Macrophage;Measurement;member;mesoxalonitrile;metabolic abnormality assessment;Metabolism;MicroRNAs;microvesicles;Mitochondria;Molecular;Molecular and Cellular Biology;Molecular Biology;Monoglycerides;Morphology;Mus;Muscle;Muscle Cells;Myoblasts;Names;Needs Assessment;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;Nonesterified Fatty Acids;Nutrient;nutrition;Nutritional;Obesity;Obesity associated disease;Organ;Outcome Study;Participant;Pathogenesis;Peripheral Blood Mononuclear Cell;Peroxisome Proliferator-Activated Receptors;phenylhydrazone;Phosphate Buffer;Plasma;Polymerase Chain Reaction;PPARG gene;precursor cell;Procedures;Proteins;Protocols documentation;pyruvate carrier;red fluorescent protein;Research;Research Personnel;research study;Research Support;RNA;Saline;Services;sex;Signal Transduction;skills;Small Interfering RNA;Standardization;Stromal Cells;System;Technology;Thermography;tissue preparation;tissue respiration;Tissue Sample;Tissues;Titrations;Training;Transferase;Translational Research;Triglycerides;Universities;uptake;Washington;Writing

PROJECT_TITLE: Cellular and Molecular Biology Core


ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Chromosomal rearrangements are a primary form of human mutation that alters genome function in diseases such as cancer and inherited genetic syndromes. This project explores a series of contextual influences on the formation of chromosomal rearrangements through DNA double-strand break repair, including local sequences, genomic factors and metabolic signaling. Results will provide novel insights into how these cellular processes normally preserve the genome and how rearrangements result when they are perturbed by environmental or genetic factors.

PI_NAMEs: WILSON, THOMAS EDWARD (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: 5'-AMP-activated protein kinase;base;Base Pairing;Biochemical Pathway;Biochemistry;Biological Assay;Biological Testing;Carbon;Cell Cycle;Cell Physiology;Cells;Chromatin;Chromosomal Rearrangement;Complex;Coupled;crosslink;Data;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Sequence Alteration;DNA Sequence Rearrangement;Double Strand Break Repair;Eukaryota;Event;Excision;follow-up;Frequencies;Galectin 1;Gene Expression;Genes;Genetic;Genetic Epistasis;Genome;Genomics;GLC2 protein;Glucose;Grant;Health;Hereditary Disease;homologous recombination;Human;improved;In Vitro;in vivo;Inherited;insight;Lead;Literature;Location;Maintenance;Malignant Neoplasms;Mediator;Metabolic;Metabolism;metabolomics;Methods;Mitotic;Modeling;Molecular;Monitor;Movement;Mutagenesis;mutant;Mutation;Nonhomologous DNA End Joining;Normal tissue morphology;novel;Nuclear;Nucleotides;Outcome;Parents;Pathway interactions;Pattern;preservation;Primer Extension;Property;protein function;Proteins;Regulation;repaired;Reporter;Resolution;response;Series;Shapes;Signal Transduction;Site;Source;Southern Blotting;Specificity;stem;success;Syndrome;System;Testing;transcription factor;transcriptomics;Update;Variant;Work;Yeasts

PROJECT_TITLE: Early events in double-strand break repair in local, genomic and metabolic contexts

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The present research activity will expand upon recent studies that have shown that light at certain wavelengths and in adequate doses can temporarily block neural transmission of pain information, resulting in strong relief. The present research will yield critical understanding of the light-induced changes in neural signaling and pain relief at various doses. Finally, the research will include development of prototype PBM systems and evaluation of those systems in a pre-clinical model.

PI_NAMEs: ANDERS, JUANITA J;JENKINS, MICHAEL W.;MOFFITT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;American;Analgesics;animal pain;Animals;Axon;behavior test;Biological;Chronic;chronic pain;chronic pain management;Chronic pain syndrome;Clinic;Clinical;Computer Models;Confocal Microscopy;Data;Dependence;Development;Device Designs;Devices;direct application;Dose;Electron Microscopy;Elements;Evaluation;experience;Family suidae;Fiber;first-in-human;Foundations;Goals;Health;Heating;Hour;Human;Image;Implant;implantable device;in vivo;insight;interest;Intervention;Investigation;Light;Literature;Longitudinal Studies;Microtubules;Miniature Swine;Modeling;Nerve;Nerve Block;neural;Neuritis;Neurons;neurotransmission;Nociception;nociceptive response;Operative Surgical Procedures;Opioid;opioid overdose;Pain;pain model;pain reduction;pain relief;painful neuropathy;Patients;Peripheral Nerves;pharmacologic;photobiomodulation;Physiological;Pilot Projects;pre-clinical;Pre-Clinical Model;preclinical development;preclinical evaluation;preclinical study;Preparation;Property;prototype;Radiofrequency Interstitial Ablation;Randomized, Controlled Trials;Rattus;Reporting;Research;Research Activity;response;Rodent;Rodent Model;Role;sciatic nerve;Societies;Source;Spinal Ganglia;Spottings;standard of care;Structure;Synaptic Transmission;System;Techniques;Technology;Therapeutic;Time;Tissues;tool;Translations;transmission blocking;United States;Varicosity;Work;wound healing

PROJECT_TITLE: Characterization of the Properties and Mechanisms of Photobiomodulation-Induced Axonal Block and Evaluation as a Treatment for Neuropathic Pain

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


PI_NAMEs: FINCK, BRIAN N (contact)

PROJECT_TERMS: Abbreviations;Accreditation;Adopted;animal care;Animal Experimentation;Animal Model;Animals;Area;Automation;Biochemical;Biodistribution;Biological Assay;Body Composition;Brown Fat;CD36 gene;Cellular biology;Cholesterol;Clinical Sciences;Collaborations;comparative;Complex;Computers and Advanced Instrumentation;Consultations;Cost Savings;Diabetes Mellitus;endurance exercise;energy balance;Energy Metabolism;Ensure;Equilibrium;Equipment;Evaluation;Exercise;exosome;Experimental Designs;FABP1 gene;Fatty Acid-Binding Protein 1;Feedback;Funding;Genetic Engineering;Glucose;Goals;Green Fluorescent Proteins;Health;Human;human disease;IACUC;imaging approach;improved;in vivo;Individual;insight;Institution;instrumentation;Investments;Label;Laboratory Animals;Lipids;Magnetic Resonance;Measures;medical schools;Medicine;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Mitochondria;Modeling;Molecular Biology;Mus;new technology;Nicotinamide adenine dinucleotide;nicotinamide phosphoribosyltransferase;Nonesterified Fatty Acids;nutrition;Nutritional;Obesity;operation;Organ;Outcomes Research;Pathogenicity;Persons;Phenotype;Positron;Positron-Emission Tomography;Preclinical Testing;Procedures;Productivity;pyruvate carrier;Radiology Specialty;Rattus;red fluorescent protein;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;Rodent Model;Science;Serum;service utilization;Services;Standardization;Techniques;Technology;Testing;Therapeutic Agents;Tissues;tomography;Training;Training Programs;transcription factor;treadmill;Triglycerides;U-Series Cooperative Agreements;Universities;uptake;Washington;X-Ray Computed Tomography

PROJECT_TITLE: Animal Model Research Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative This project will determine the degree to which depression in older adults is associated with progressive brain atrophy and increased tau deposition that contribute to increased risk for cognitive decline and dementia. This study is important for identifying new treatments for cognitive decline in older adults with depression.

PI_NAMEs: MACKIN, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Acceleration;Accounting;Address;Age;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Apolipoprotein E;Apolipoproteins;Area;arm;Atrophic;Bilateral;cerebral atrophy;Cerebrovascular Circulation;Cerebrovascular Disorders;Characteristics;Chronic;chronic depression;Clinical;Cognition;Cognition Disorders;Cognitive;comorbidity;comparison group;Data;Dementia;Deposition;depressive symptoms;design;entorhinal cortex;Evaluation;executive function;Exhibits;functional decline;Genetic;Genetic Risk;geriatric depression;Goals;Hippocampus;Impaired cognition;Individual;Inferior;information processing;Insula of Reil;Lateral;Lesion;life span;Link;Magnetic Resonance Imaging;Measures;Medical;Memory;Mental Depression;Nerve Degeneration;Neurobiology;neuroimaging;Neurons;older adult;Outcome;parent project;Parents;Participant;Pathology;Positron-Emission Tomography;Recording of previous events;research clinical testing;Risk;Risk Factors;Scanning;secondary analysis;Selective Serotonin Reuptake Inhibitor;Severities;sex;Speed;Symptoms;tau Proteins;Temporal Lobe;white matter;Work

PROJECT_TITLE: Characterizing Cognitive Decline in Late Life Depression: The ADNI-D Project

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: Mitigation of Radiation-Induced Immune Dysfunction by PrC-210 Treatment PROJECT NARRATIVE Human risk of radiation exposure, possibly catastrophic in proportion, has risen. Whether from intentional or unintentional nuclear events, such events could yield thousands to hundreds of thousands of surviving victims. A US government report stated, “the ideal medical countermeasures for radiation would be those that can both mitigate and protect from injuries.., such a countermeasure remains a significant unmet medical need.” The new, proprietary, PrC-210 radiation countermeasure, when administered once 24 hr post-radiation, confers a very large survival benefit against an LD95/30 radiation dose in mice. The goals of this U01 proposal are to i) determine the optimum +24 hr PrC-210 administration route and dose, and ii) determine the full extent to which PrC-210 mitigates damage to immune and gastrointestinal organ sites. These studies are proposed as a prelude to PrC-210 clinical trials.

PI_NAMEs: FAHL, WILLIAM E;GHOSH, SANCHITA P;GOESCH, TORSTEN ;KUMAR, VIDYA  (contact)

PROGRAM_OFFICER_NAME: WINTERS, THOMAS A

PROJECT_TERMS: aminothiol;Animals;Area;Bacterial Translocation;Biological Markers;Blood;Blood Cells;Body Weight;Bone Marrow;Bone Marrow Aspiration;C57BL/6 Mouse;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;chemokine;Chernobyl Nuclear Accident;Clinical Trials;cytokine;Dendritic Cells;dirty bomb;Disasters;Dose;Drug Kinetics;Event;exposed human population;Exposure to;Female;Femur;fluorescein isothiocyanate dextran;Fukushima;gastrointestinal;Goals;Government;Growth Factor;Hematology;Hematopoietic stem cells;Histology;Human;Hypotension;Immune;immune cell infiltrate;immune function;Immune system;Immune System Diseases;Immunology;improved;Inflammation;Inflammatory;Injury;invention;Ionizing radiation;irradiation;jejunum;Lethal Dose 50;Liver;Macrophage;male;Measurable;Measures;Medical;medical countermeasure;Modeling;Mucous Membrane;Mus;Natural Killer Cells;Nausea;novel;Nuclear;Nuclear Accidents;Nuclear Reactors;Nuclear Weapon;Oral;Organ;Pathology;pharmacologic;Plasma;preclinical development;protective effect;Proteome;Protocols documentation;Radiation;radiation countermeasure;Radiation Dose Unit;Radiation exposure;Radiation induced damage;Radiation Injuries;radiation mitigation;radiation risk;Recovery;Regulatory T-Lymphocyte;Reporting;Research;Rodent;Route;side effect;Site;Spleen;Sulfhydryl Compounds;Survivors;Testing;Thymus Gland;Time;Tissue Survival;Tissues;urban setting;Vomiting;Whole-Body Irradiation;Work

PROJECT_TITLE: Mitigation of Radiation Induced Immune Dysfunction by PrC-210 Treatment


NIH_SPENDING_CATS: Dissemination and Implementation Research;Nutrition;Obesity

PI_NAMEs: HAIRE-JOSHU, DEBRA  (contact)

PROJECT_TERMS: Abbreviations;Acceleration;Address;Applications Grants;Area;clinical care;clinical practice;Clinical Sciences;Clinical Trials;Community Health;Consultations;Diabetes Mellitus;Dissemination and Implementation;dissemination science;Ensure;Equity;Event;Evidence based practice;Fostering;Goals;Health Policy;implementation design;implementation research;implementation science;improved;Individual;Intervention;Investments;Knowledge;knowledge translation;Manuscripts;medical schools;Methodology;Methods;novel;nutrition;Obesity;Online Systems;Phase;Phase I Clinical Trials;Policies;Population;population health;Productivity;programs;Publications;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Science;Services;skills;Training;Translational Research;Universities;Washington

PROJECT_TITLE: Dissemination and Implementation Science Core


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: BALTIMORE

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE Children with Attention Deficit Hyperactivity Disorder (ADHD) are at substantially increased risk for long- term difficulties into adulthood, including academic underachievement, substance abuse, and criminal behavior. In our effort to improve these outcomes, we have worked on identifying highly-reliable motor measures that could be used to help better guide ADHD treatment, leading to the discovery of two brain- based measures that are abnormal in children with ADHD and, importantly, also predict the severity of ADHD behaviors. We aim to determine whether these two measures, performed with brief and safe Transcranial Magnetic Stimulation (TMS), are reliable and meaningful enough to be used to help improve precision of individually-targeted and effective ADHD treatments.

PI_NAMEs: MOSTOFSKY, STEWART H (contact)

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: 12 year old;Acute;Address;Adult;Adverse event;Attention;Attention deficit hyperactivity disorder;Behavior;Behavior Therapy;Behavioral;Biological Markers;biomarker development;biomarker performance;biomarker validation;Blinded;brain based;Categories;Child;Childhood;Cities;Clinical;clinical practice;Clinical Trials;clinically relevant;Cognitive;cognitive control;criminal behavior;Data;design;Diagnosis;Diagnostic;Disease;distraction;Dopamine;Dose;effective intervention;Emotional;Evaluation;follow-up;Foundations;Friends;Functional disorder;Funding;Future;Genetic;Grant;Hand;Impairment;improved;improved outcome;Individual;innovation;inpatient psychiatric treatment;Intervention;Investigation;Link;Measures;Membrane Potentials;Mental disorders;Methods;Modeling;Motor;motor control;Motor Cortex;Motor Evoked Potentials;Muscle;Negative Valence;neurochemistry;neurophysiology;novel;Outcome;Parents;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pharmacology Study;Physiological;Physiology;Placebo Control;Placebos;potential biomarker;Precision therapeutics;prognostic;psychostimulant;Publishing;Reaction Time;Research;Research Domain Criteria;response;Rest;Rewards;Risk;Risk Factors;Ritalin;School-Age Population;Selection for Treatments;Severities;Signal Transduction;Site;Stimulant;Subgroup;Substance abuse problem;Surface;Symptoms;System;Testing;Transcranial magnetic stimulation;treatment strategy;Underachievement;Validation;Work

PROJECT_TITLE: 2/2 - Anomalous Motor System Physiology in ADHD: Biomarker Validation and Modeling Domains of Function

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: REEDS, DOMINIC N (contact)

PROJECT_TERMS: Abbreviations;Academic support;Address;Applications Grants;Award;California;career;clinical investigation;Clinical Sciences;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Development;Diabetes Mellitus;Embryo;Endoplasmic Reticulum;Extramural Activities;Faculty;Fibroblasts;Foundations;Funding;Goals;Grant;Los Angeles;Manuscripts;Master of Science;medical schools;Medicine;member;Mentors;Mentorship;Mission;Mus;next generation;nicotinamide phosphoribosyltransferase;Nonesterified Fatty Acids;novel;nutrition;Obesity;Peer Review;Principal Investigator;programs;Publications;Research;Research Personnel;Research Support;Scientific Societies;Testing;Training Programs;Translational Research;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Pilot and Feasibility Program


NIH_SPENDING_CATS: Genetics;Lung;Pulmonary Hypertension;Rare Diseases;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Pulmonary arterial hypertension is a sex-biased disease, with no cure and nearly always lethal. Our recent studies indicated that female pulmonary artery endothelial cells have a higher proliferative potential compared to the male ones, due to augmented expression and activity of Xist, a nuclear factor responsible for inactivation of one of the chromosome X in females. This is significant, as understanding the female prevalence in pulmonary arterial hypertension could guide sex-specific diagnostic and treatment.

PI_NAMEs: PREDESCU, SANDA A (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Age;Animal Model;Arterial Disorder;Behavior;Biological Assay;Blood Vessels;Bromodeoxyuridine;CCND2 gene;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Proliferation;Cessation of life;cyclin A1;Data;Diagnostic;Disease;Dosage Compensation (Genetics);elk-1 protein;Endothelial Cells;endothelial dysfunction;Endothelium;Estrogens;Ethnic Origin;Event;Failure;Female;Fluorescent in Situ Hybridization;Gene Expression;Genes;Genetic;genetic analysis;Genetic Transcription;genome wide association study;Germ Cells;Gonadal Steroid Hormones;Granzyme;hemodynamics;Heterozygote;Histology;Homeostasis;Human;human disease;human female;human male;Immunohistochemistry;Immunoprecipitation;In Vitro;Incidence;Inflammatory;intersectin 1;Investigation;knock-down;Label;Lesion;Link;Luciferases;Lung;male;Mass Spectrum Analysis;Measurement;Mediating;men;Metabolism;Modeling;Molecular;mouse model;Mus;N-terminal;novel;Nuclear;Pathologic;Patients;PECAM1 gene;Peptides;Phenotype;Physiologic pulse;Physiological;Population Study;Predisposition;prevent;Proliferating;Proteins;Publishing;pulmonary arterial hypertension;Pulmonary arterial remodeling;pulmonary artery endothelial cell;Race;response;right ventricular failure;RNA;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Pathway;Small Interfering RNA;Specimen;Structure of parenchyma of lung;Therapeutic;therapeutic target;Transcript;transcription factor;Transfection;Untranslated RNA;Up-Regulation;Vascular Proliferation;Vascular remodeling;Woman;women subjects;Women's prevalence;X Chromosome;X Inactivation

PROJECT_TITLE: Cleavage of intersectin-1s by Granzyme B and Pulmonary Arterial Hypertension

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Alzheimer’s disease (AD) represents a major social and public health problem which will worsen as our population ages. This longitudinal observational cohort study is describing the timecourse of presymptomatic proteinopathy and cognitive decline and the influence of risk factors. Discoveries will inform early detection, prognosis planning, and interventions that delay or slow the progression of the disease.

PI_NAMEs: JOHNSON, STERLING C (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Affect;Age;Age of Onset;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Arterial Injury;Astrocytes;Atherosclerosis;Biological Assay;Biological Markers;Blood Vessels;Brain;brain health;brain magnetic resonance imaging;cerebrovascular;cerebrovascular health;Characteristics;Clinical;Cognitive;cognitive change;cognitive performance;cohort;Collaborations;Data;Dementia;Diagnosis;Diagnostic;Disease;Disease Progression;Early Diagnosis;Enrollment;follow-up;Funding;Genetic;Genetic Risk;Glial Fibrillary Acidic Protein;Goals;Health;human old age (65+);Impaired cognition;Impairment;improved;Individual;Injury;innovation;Intervention;ischemic lesion;Knowledge;Length;Life Style;lifestyle factors;Literature;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Mediating;Medical;Methods;middle age;Modeling;Nerve Degeneration;Neurons;novel;observational cohort study;Outcome;Participant;peer;Performance;Persons;Phenotype;Plasma;Population;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Prognosis;Public Health;Publishing;Recording of previous events;Registries;Risk;Risk Factors;Sampling;sex;social;Symptoms;tau Proteins;Tauopathies;Techniques;Time;ultrasound;Vascular Cognitive Impairment;Vascular Diseases;Visit;White Matter Hyperintensity;Wisconsin

PROJECT_TITLE: Wisconsin Registry for Alzheimer's Prevention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-B(02)M]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE This Training Program based in a large Division of Pediatric Rheumatology (PR) with several NIH center grants and NIH-funded investigators seeks to equip PR fellows with the investigative skills necessary to succeed in research careers. The research training activities will have two focus areas: (1) application of genomics, epigenetics, proteomics, and metabolomics to advance PR translational research, and (2) clinical epidemiology, development of clinical outcome assessment tool and clinical trial design. It is expected that this program will enlarge the number of PR researchers, a pool that is far too small to meet the requirements of the next decades as molecular medicine is increasingly applied in the clinic.

PI_NAMEs: GROM, ALEXEI A (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Childhood;Training Programs

PROJECT_TITLE: CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCH


PI_NAMEs: DEBOSCH, BRIAN JESSE (contact)

PROJECT_TERMS: Abbreviations;Area;Basic Science;Charge;Clinical Investigator;Clinical Nutrition;Clinical Sciences;clinically relevant;Collaborations;Community Health Education;Diabetes Mellitus;Discipline;dissemination science;Education;Faculty;Feedback;follower of religion Jewish;Fostering;Growth;Hospitals;implementation science;Interest Group;Interview;lectures;Logistics;Medical center;medical schools;member;Metabolism;metropolitan;Newspapers;next generation;non-alcoholic fatty liver disease;nutrition;Nutrition management;Obesity;obesity management;peer;Physicians;Press Releases;professor;programs;Qualifying;Radio;Research;Research Personnel;Research Project Grants;Schedule;Services;success;Television;Training;Training and Education;Universities;Visit;Washington

PROJECT_TITLE: Enrichment Program