NIH_SPENDING_CATS: Infant Mortality;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Sudden Infant Death Syndrome

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Sudden Infant Death Syndrome (SIDS) is a leading cause of neonate death in the United States with failure of the autoresuscitation reflex being hypothesized as a common endpoint in many SIDS cases. Two of the most commonly found abnormalities in SIDS cases are in the central serotonergic (5-HT) and noradrenergic (NA) systems. We aim to determine the potential interactive roles of the 5-HT and NA systems in the autoresuscitation reflex by utilizing novel intersectional genetic mouse tools for concurrent excitation and inhibition of the 5-HT and NA systems to better understand SIDS pathophysiology and possibly reveal avenues for therapeutic intervention.

PI_NAMEs: LUSK, SAVANNAH J (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Anoxia;Autopsy;Biological Assay;Brain Stem;Breathing;Breeding;Cause of Death;Cells;Cessation of life;Clozapine;combinatorial;Compensation;congenital respiratory disorder;course development;Data;Development;Diagnostic;Disease;disease diagnosis;Educational workshop;Environment;Equipment;Failure;Foundations;Functional disorder;Future;Genetic;genetic manipulation;Health;Homeostasis;Immunohistochemistry;Infant;Infant Mortality;Investigation;Joints;Knowledge;Lesion;Life;Link;loss of function;Medical History;Methodology;Methods;mortality;Mus;Neonatal Mortality;neonate;neural network;neuroregulation;noradrenergic;novel;Outcome;Oxides;pharmacologic;Phenotype;Population;protective effect;recombinase;Reflex action;Regulation;Research;Resolution;Respiration Disorders;respiratory;Respiratory Center;respiratory challenge;respiratory reflex;Respiratory System;response;Role;Serotonergic System;Serotonin;Solid;Stains;Sudden infant death syndrome;Symptoms;System;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Toxin;Training;United States;Work

PROJECT_TITLE: Interactions of the Noradrenergic and Serotonergic Systems in Autoresuscitation


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Urologic Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PI_NAMEs: POLLACK, JONATHAN R (contact)

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Address;Adrenergic Receptor;Affect;Androgens;ATAC-seq;Atlases;Automobile Driving;Benign;Benign Prostatic Hypertrophy;Biological Markers;Biological Models;Bladder;BMP5 gene;Categories;Cell Communication;Cells;ChIP-seq;Chromatin;Clinical;Communities;comparative;CXCL13 gene;Data;Differentiation and Growth;Disease;Drug Targeting;Elements;Embryo;Embryonic Development;Enhancers;Epithelial Cells;Epithelium;Fibroblasts;Frequencies;Functional disorder;Gene Expression Profile;genetic signature;Genomics;Goals;Growth;Health Care Costs;Histology;Immunohistochemistry;Inflammation;Inflammatory Response;Injury;Knowledge;Ligands;lower urinary tract symptoms;Magnetic Resonance Imaging;Maps;Medical;Methods;Mining;Morbidity - disease rate;Multiplexed Ion Beam Imaging;Mus;Muscle Tonus;Myofibroblast;Neighborhoods;new technology;Normal tissue morphology;older men;overexpression;Pathogenesis;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Physiology;Precision therapeutics;preclinical study;Proliferating;Prostate;prostate enlargement;Prostatic hypertrophy;receptor;Regulation;Relaxation;Research;Resources;response to injury;Sampling;Severities;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Smooth Muscle;Specimen;Symptoms;targeted treatment;Therapeutic;Time;Tissue Model;Tissues;transcriptome;transcriptome sequencing;Urethra;urinary;Urology

PROJECT_TITLE: Fibroblast subsets in BPH pathogenesis


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Child survivors of severe infection may experience long-term physical problems. This K99/R00 proposal will comprehensively describe a cohort of children who survive sepsis and explore the potential role of inflammation in post-sepsis physical dysfunction. We will develop and refine PEdiatric Recovery after sepSIS Treatment in the Pediatric Intensive Care Unit (PERSIST-PICU), a multivariable model to identify a child’s risk for physical dysfunction so that future research can optimize physical function in those who need it most.

PI_NAMEs: PERRY-EADDY, MALLORY A (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute Lung Injury;Address;Adult;Age;Award;biobank;biobehavior;Biological;Biological Markers;Biometry;C-reactive protein;career;Career Transition Award;Cause of Death;Child;Childhood;cohort;Communities;Complex;Critical Care;Critical Illness;Critically ill children;Data;Data Set;Development;Early identification;Early Intervention;Education;Environment;Evaluation;Evolution;experience;Family;follow-up;Functional disorder;Future;Genetic Markers;Genetic Variation;Genotype;Growth and Development function;Health;Hospitals;Iatrogenesis;Immersion;improved;Individual;Infection;Inflammation;Inflammation Mediators;Inflammatory;Intensive Care;Interleukin-6;Interleukin-8;Intervention;Knowledge;Longitudinal cohort study;Measures;meetings;Mentors;Mentorship;Mission;model development;Modeling;Morbidity - disease rate;Muscular Atrophy;National Institute of Nursing Research;Nature;Nurses;Pediatric Hospitals;Pediatric Intensive Care Units;pediatric sepsis;Pediatrics;Pennsylvania;Performance;Phase;Phenotype;Philadelphia;Physical Function;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Predictive Analytics;programs;prospective;Quality of life;Randomized;Recovery;Rehabilitation therapy;Reporting;Research;Research Design;Research Personnel;Respiratory Failure;Risk;Role;Sampling;Scientist;Sedation procedure;Sepsis;Site;skills;Statistical Methods;Survivors;symposium;symptom science;Syndrome;Techniques;Titrations;Training;Universities;Validation;Vulnerable Populations;wasting;Work

PROJECT_TITLE: Pediatric Recovery After Sepsis Treatment in the Pediatric Intensive Care Unit

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Aging;Immunotherapy;Urologic Diseases

PI_NAMEs: WEST, ROBERT B (contact)

PROJECT_TERMS: Affect;associated symptom;Benign Prostatic Hypertrophy;Biological;Cell Communication;Cell Physiology;cell type;Cells;Clinical;Communities;Computer Models;CXCL13 gene;Development;differential expression;Disease;Ecosystem;Epithelial Cells;Epithelium;Functional disorder;Gene Expression Profiling;Genes;Goals;Immune;Immune response;immunoregulation;Infection;Inflammation;insight;late life;Lead;lower urinary tract symptoms;Measures;men;Multiplexed Ion Beam Imaging;Pathogenesis;Pathway interactions;Physiology;Play;Population;Proliferating;Prostate;Prostatic Tissue;Prostatic Urethra;Research;response;RNA;Role;senescence;senescent cell;spatial relationship;Stromal Cells;T cell clonality;Therapeutic;Time;Tissue Expansion;tumor-immune system interactions;Urology

PROJECT_TITLE: Immune microenvironment in BPH pathogenesis


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Pregnancy;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: In South Africa, pregnant and breastfeeding women are at elevated risk of acquiring HIV, and pre-exposure prophylaxis (PrEP) is a safe and effective HIV prevention strategy; however, posttraumatic stress and depression, which are prevalent in this population, negatively impact PrEP adherence and persistence. This study will (1) explore the mechanisms by which posttraumatic stress and depression impact PrEP use during pregnancy and the postpartum transition; (2) develop a brief intervention that addresses common underlying factors of posttraumatic stress and depression to improve PrEP adherence and persistence; and (3) evaluate the feasibility and acceptability of the intervention when delivered in a community-based antenatal care setting. If feasibility, acceptability, and preliminary efficacy are demonstrated, then the intervention will be ready for large- scale efficacy/effectiveness testing.

PI_NAMEs: STANTON, AMELIA M. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;AIDS prevention;antenatal;antenatal care;Behavioral;Blood;Breast Feeding;brief intervention;career;Clinic;Clinical;Clinical Psychology;Cognitive Therapy;Communities;Data;Data Analyses;depressive symptoms;Development;Discipline of obstetrics;Doctor of Philosophy;Domestic Violence;Dryness;Educational process of instructing;Educational workshop;Effectiveness of Interventions;effectiveness testing;efficacy evaluation;emotional abuse;empowerment;emtricitabine;Epidemic;experience;feasibility testing;Focus Groups;Formulation;General Hospitals;Goals;Grant;group intervention;Health behavior;high risk;High Risk Woman;HIV;HIV Infections;HIV risk;implementation facilitators;implementation framework;improved;Incidence;Income;innovation;Interruption;Intervention;intervention refinement;Interview;intimate partner violence;K-Series Research Career Programs;Late pregnancy;Life Experience;Massachusetts;Measures;medical schools;Mental Depression;mental development;Mental Health;Mentors;Mentorship;Midwife;National Institute of Mental Health;Oral;Outcome;Patient Self-Report;Perinatal transmission;Population;post-traumatic stress;Post-Traumatic Stress Disorders;post-traumatic symptoms;Postdoctoral Fellow;Postpartum Period;Postpartum Women;pre-exposure prophylaxis;preference;Pregnancy;pregnant;Pregnant Women;Prevalence;prevent;Prevention strategy;primary outcome;Procedures;Provider;Psychiatry;psychologic;Psychological Impact;Psychologist;psychosocial;psychosocial development;Public Health;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Resource-limited setting;Risk;Sampling;secondary outcome;Self Care;seroconversion;sexual assault;Sexual Health;skills;social stigma;Social support;South Africa;South African;Spottings;Structure;Tenofovir;Testing;therapy development;Time;Training;Trauma;treatment as usual;trend;Verbally abusive behavior;Withdrawal;Woman;Women's Health;women's prevention

PROJECT_TITLE: Reducing psychological barriers to PrEP persistence among pregnant and postpartum women in Cape Town, South Africa

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE - Overall Our goal is to attract trainees and young investigators from across the US to study normal hematopoiesis and non-malignant blood diseases that can be cured with stem cell transplantation. A diverse work force is needed to bring people with different perspectives together in synergistic collaborations which can speed discovery, however, the tools needed to advance this science may be out of reach for many independent investigators. This NIDDK Core Center addresses this challenge by providing access to resources at reduced rates, funds for pilot studies, and a virtual community of supportive colleagues.

PI_NAMEs: STIREWALT, DEREK L (contact)

PROGRAM_OFFICER_NAME: NORTON, JENNIFER MICHELLE

PROJECT_TERMS: Address;Adherence;Advisory Committees;Amendment;Animal Model;Area;Award;base;Biological Assay;Biological Products;Biology;Biomedical Research;canine model;Canis familiaris;CD34 gene;Cells;Charge;Chimerism;Collaborations;Communities;Consultations;cost;cost effective;Country;data sharing;design;Development;Direct Costs;disease model;Doctor of Philosophy;Dog Diseases;Educational workshop;Ensure;experience;Faculty;Fee-for-Service Plans;Fred Hutchinson Cancer Research Center;Funding;gene editing technology;Gene Expression;Gene Modified;gene therapy;Genes;genetic manipulation;Goals;graft vs host disease;Grant;Hematological Disease;Hematology;Hematopoiesis;Human;In Vitro;in vivo;in vivo evaluation;in vivo Model;Income;Individual;Institution;Internships;Liquid substance;Logistics;Measurement;Measures;Mediating;member;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;new technology;Nitrogen;Non-Malignant;novel therapeutics;online community;organizational structure;Outcome;outcome prediction;Patients;Persons;Pilot Projects;Positioning Attribute;pre-clinical;Pre-Clinical Model;prevent;Procedures;Process;Production;programs;Protocols documentation;pyruvate kinase deficiency;quality assurance;Quality Control;recruit;Research;Research Personnel;Resources;Safety;Science;Services;Severe Combined Immunodeficiency;Shipping;Site;Speed;Spumavirus;Stem cell transplant;stem cells;tool;Training;transplant model;Transplantation;Travel;treatment response;Underrepresented Populations;Underrepresented Students;Underserved Population;Universities;Viral;virtual;Washington;web site;Work;Xenograft procedure

PROJECT_TITLE: Stem Cell and Transplantation Biology


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PI_NAMEs: TOROK-STORB, BEVERLY J. (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Award;Back;base;Biology;Biomedical Research;Budgets;Cells;Characteristics;Charge;Collaborations;Communication;Data;data archive;data sharing;Decision Making;Development;Educational process of instructing;Ensure;Evolution;experience;Faculty;Fees;follow-up;Funding;genetically modified cells;Grant;Hematology;High School Student;Income;Learning;meetings;member;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;new technology;Online Systems;organizational structure;outreach program;Play;Postdoctoral Fellow;posters;Process;programs;Protocols documentation;Recording of previous events;Research;Research Personnel;Resources;Role;satisfaction;searchable database;Services;Specific qualifier value;stem cells;Techniques;Time;tool;Training;Transplantation;underrepresented minority student;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

PROJECT_TERMS: Award;Awareness;base;Bioinformatics;Biology;Cells;Characteristics;Clinical;Collaborations;Communities;cost;Data;Data Management Resources;Disease;Documentation;Educational workshop;Ensure;Equipment and supply inventories;experience;Explosion;Feedback;follow-up;Funding;Funding Mechanisms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;high standard;improved;Individual;Infrastructure;innovation;Institution;Investigation;Measures;meetings;member;Modeling;multidimensional data;Nature;new technology;Non-Malignant;novel;novel strategies;posters;precursor cell;Price;Production;programs;quality assurance;Quality Control;Recording of previous events;Reproducibility;Research;Research Personnel;Resources;Retrieval;satisfaction;searchable database;skill acquisition;software development;software systems;Specimen;Standardization;stem cells;success;Surveys;Techniques;Technology;Testing;text searching;Time;tool;Transplantation;user-friendly;virtual;web site;Work

PROJECT_TITLE: Cell Procurement & Processing


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE This proposal will characterize mechanisms and molecular determinants of KRASG12C-mutant NSCLC immune sensitization in response to KRASG12C inhibitor monotherapy and combinations with chemotherapy and/or immune checkpoint inhibitors using immune-competent animal models and clinical specimens.

PI_NAMEs: SKOULIDIS, FERDINANDOS  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Animal Model;anti-PD1 therapy;anti-tumor immune response;Autologous;Biological;Biopsy;Cancer cell line;Cell Death Induction;Cells;Cessation of life;chemotherapy;Cisplatin;Clinical;clinical efficacy;clinically significant;Combined Modality Therapy;Data;Data Set;Development;DNA Sequence Alteration;early phase clinical trial;Exhibits;experimental study;Foundations;Genetic Engineering;Genetically Engineered Mouse;genomic profiling;Heterogeneity;Human;Immune;Immune checkpoint inhibitor;Immune response;Immune signaling;Immuno-Chemotherapy;Immunocompetent;immunogenic cell death;Immunologic Memory;Immunologic Sensitization;Immunologics;Immunology procedure;Immunotherapy;improved;individual response;inhibitor;insight;KRAS2 gene;Mediating;Medicine;Molecular;mouse model;Mus;mutant;Mutation;Neoadjuvant Therapy;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;objective response rate;Oncogenic;Oncoproteins;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Patients;PD-1 inhibitors;Pemetrexed;Phase II Clinical Trials;Plasma;Platinum;Population;Pre-Clinical Model;programmed cell death ligand 1;programmed cell death protein 1;Property;Research Personnel;Resected;Resistance;Resolution;Resources;response;Sampling;Shapes;Specimen;standard of care;STK11 gene;synergism;Systemic Therapy;T memory cell;targeted cancer therapy;Therapeutic;TP53 gene;tumor;Tumor Immunity;Tumor Suppressor Genes;tumor-immune system interactions;Work

PROJECT_TITLE: Understanding and harnessing immune-modulatory effects of covalent KRASG12C inhibitors in KRASG12C-mutant non-small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Germ granules are highly conserved organelles implicated in gene regulation and germline maintenance. The goal of this research program is to define and characterize germ granules to better understand how they impact development and human health. Ultimately this work will provide new knowledge and possibly therapeutics that will improve human fertility.

PI_NAMEs: TANG, WEN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Address;Biochemical;Biological Models;Caenorhabditis elegans;Cytoplasmic Granules;Dedications;Development;Embryonic Development;Epigenetic Process;Fertility;Gene Expression Regulation;gene regulatory network;Genetic;Germ;Germ Cells;Germ Lines;Goals;Health;Heritability;Human;improved;Knowledge;macromolecule;Maintenance;Membrane;Nature;next generation;offspring;Organelles;Production;programs;Proteins;Proteome;Research;RNA;Role;Small RNA;Therapeutic;transgenerational epigenetic inheritance;transmission process;Work

PROJECT_TITLE: Heritable macromolecules in C. elegans germ granules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PI_NAMEs: KIEM, HANS-PETER  (contact)

PROJECT_TERMS: Alleles;base;Biological;Biological Assay;Biology;Canis familiaris;CD34 gene;Cells;Consultations;Cost Savings;Development;Disease;Flow Cytometry;functional genomics;Gene Expression;Gene Library;gene therapy;Genes;genetic manipulation;Genetic Services;Genetic Vectors;Genome;Goals;Grant;Hematopoiesis;Hematopoietic;Human;Human Genome;improved;In Vitro;in vivo;Individual;Infrastructure;insertion/deletion mutation;Knowledge;Measures;Mediating;Mission;Mutation;new technology;nucleofection;Performance;Production;Protocols documentation;PTPRC gene;Reagent;Records;Research Personnel;RNA;Scientist;screening;Services;stem;stem cells;targeted treatment;Techniques;Technology;technology platform;tool;Transfection;Transplantation;vector;vector control;Viral;Viral Vector;Virus

PROJECT_TITLE: Cell Manipulation Tools


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;Clinical Research;Dietary Supplements;Endocrine Disruptors;Estrogen;Lead Poisoning;Menopause;Nutrition;Obesity;Osteoporosis;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Healthy bone is critical for long term health not only to minimize fracture risk and related morbidity and mortality, but as an endocrine organ with influence on energy homeostasis, mineral metabolism, and adiposity. The goal of this longitudinal study is to investigate phthalate and metals exposure across two sensitive life stages – pregnancy and peri-menopause – in relation to bone health in midlife. Findings from this work will provide insight into mechanisms of exposure-related changes in bone health, with important implications for osteoporosis, fracture risk, and metabolic and cardiovascular health, as well as identify modifiable risk factors for these significant adverse health outcomes.

PI_NAMEs: TAMAYO-ORTIZ, MARCELA ;WATKINS, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Acceleration;Adipocytes;Adipose tissue;Affect;Age Years;Alkaline Phosphatase;Biological;Biological Markers;Birth;blood lead;blood Pb concentration;Body Composition;Body mass index;bone;Bone Density;bone health;bone loss;Bone Matrix;bone metabolism;Bone remodeling;Bone structure;Cadmium;calcium supplementation;Cardiovascular Diseases;cardiovascular health;Cells;Chemicals;cohort;Collaborations;directed differentiation;Drug or chemical Tissue Distribution;Dual-Energy X-Ray Absorptiometry;early life exposure;Elderly;Endocrine;Endocrine Disruptors;Endocrine Glands;Environmental Epidemiology;Environmental Pollutants;Exposure to;Femur;fibroblast growth factor 23;follow-up;Fracture;fracture risk;Future;Goals;Gonadal Steroid Hormones;Health;Health Policy;Heavy Metals;Hip region structure;Homeostasis;Hormones;Human;indexing;Individual;insight;Insulin Resistance;Lead;lead exposure;Life;Long-Term Effects;Longitudinal Studies;Measures;Menopausal Status;Mesenchymal Stem Cells;Metabolic;Metabolism;Metal exposure;Metals;Mexico;middle age;Minerals;modifiable risk;Morbidity - disease rate;mortality;Mothers;Mus;Muscle;National Health and Nutrition Examination Survey;Nutrient;Obesity;Osteoblasts;Osteogenesis;Osteoporosis;Outcome;Participant;Pathway interactions;Perimenopause;perinatal period;personal care products;phthalates;Plastics;Population;Postmenopause;postnatal;Postpartum Period;PPAR gamma;Pregnancy;prenatal;prenatal exposure;preventive intervention;Public Health;quantitative ultrasound;randomized trial;Recording of previous events;Recovery;recruit;Reporting;Research;Risk;Risk Factors;Sampling;Serum;Skeletal Muscle;sound;Speed;Spinal;Statistical Methods;Structure;Toxic Environmental Substances;urinary;Vertebral column;Visit;Vitamin D;Woman;Work

PROJECT_TITLE: Relating phthalate and metals exposure during pregnancy and perimenopause to bone health and body composition in midlife


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The effects of rising environmental temperatures on heat-related illnesses (HRI) and acute kidney injury (AKI) are of increasing concern, particularly for vulnerable subgroups of the US population who work strenuously in hot environments. This K23 project, will explore the relationship of glucose metabolism and heat exposure on the development of AKI and renal function, using high-resolution metabolomics and big data analytics to identify metabolic profiles and underlying mechanistic pathways of farmworkers in both hot and cool working conditions. This proposal, which builds on preexisting work with farmworkers and their physiological response to heat, will focus on identifying new risk factors (e.g. impaired glucose metabolism) and early biomarkers (e.g. perturbed glucose, HRI, and inflammatory profiles) on the development of AKI that may signal those at risk for disease progression, which in turn, will offer opportunities for early intervention.

PI_NAMEs: CHICAS, ROXANA CRISTINA (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: Acclimatization;Acute Renal Failure with Renal Papillary Necrosis;Age;Agriculture;Aldosterone;Area;Automobile Driving;Awareness;Big Data Methods;bilingualism;Bioinformatics;Biological Markers;Biological Monitoring;Blood;Blood Glucose;Body mass index;Body Temperature;California;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;clinical phenotype;cohort;community engaged intervention;Community Health;Complex;Creatinine;Data;Dedications;Dehydration;design;Development;Diabetes Mellitus;Disease Progression;disorder risk;Doctor of Philosophy;early detection biomarkers;Early Intervention;Environment;farm worker;Fasting;Florida;Funding;Future;Generations;Glucose;glucose metabolism;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Guatemala;Harvest;Health;health care availability;health disparity;health equity;Heart Rate;Heat Stress;Heat Stress Disorders;Heat-Shock Proteins 90;Hispanic;Hispanic Populations;hot climate;IL8 gene;Immigrant;Impairment;Industry;Inflammation;Inflammatory;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention Trial;Investigation;Kidney;Kidney Diseases;kidney dysfunction;Latina;Link;Longitudinal Studies;Mentored Patient-Oriented Research Career Development Award;Mentorship;Metabolic;Metabolic Pathway;metabolic profile;metabolome;metabolomics;mortality;nephrogenesis;Nephrology;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Nurses;Occupational;Pathway Analysis;Pathway interactions;Phenotype;Physiological;Plasma;Play;Population;population health;Prediabetes syndrome;Prevalence;programs;Proteinuria;Protocols documentation;recruit;renal damage;Renal function;Research;Resolution;response;Risk;Risk Factors;Role;Sampling;Science;Scientist;Seasons;Serum;sex;Signal Transduction;Subgroup;success;Symptoms;Temperature;Time;TNF gene;Training;United States National Institutes of Health;Uric Acid;Vulnerable Populations;Weather;Work

PROJECT_TITLE: The Interplay between Glucose Metabolism and Heat in Kidney Disease using a Metabolomics Approach

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(82)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human;Transplantation

PI_NAMEs: HAYES, BRIAN JOSEPH (contact)

PROJECT_TERMS: Acceleration;Address;Alleles;Anemia;animal care;Animal Model;Animals;Area;Award;base;Biological;Biological Assay;biological effect of radiation;Biological Models;Biological Products;Biology;Biomedical Research;Bone Marrow;Breeding;canine model;Canis familiaris;Cell Maintenance;Cells;Chimerism;Cloning Vectors;Collection;comparative;Complement;Complex;conditioning;cost;Coupled;Development;disease model;DNA;Dog Diseases;Drug resistance;Dysmyelopoietic Syndromes;Engineering;Enzymes;experience;experimental study;expression vector;gene therapy;Genetic Variation;Germ-Line Mutation;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Hematopoietic System;Hereditary Disease;Histocompatibility;HLA Antigens;Human;human leukocyte antigen testing;IL2RG gene;In Vitro;in vivo;in vivo Model;Infrastructure;Institution;Knowledge;leukocyte antigen typing;life span;Longitudinal Studies;Measures;Medicine;Modeling;Modernization;Modification;Mus;Mutation;Names;next generation sequencing;Non-Malignant;novel;peripheral blood;Play;pre-clinical;preclinical study;Procedures;Process;Production;Pyruvate Kinase;quality assurance;Quality Control;Reagent;reconstitution;Recording of previous events;Research;Research Personnel;Resources;response;RNA;Role;Services;Severe Combined Immunodeficiency;Site;Somatic Mutation;sperm cell;Stem Cell Assay;stem cell biology;stem cell function;Stem cell transplant;stem cells;synergism;System;Technology;Therapeutic Studies;Time;tissue fixing;tissue repair;tool;Translating;transplant model;Transplantation;vector;Work;Xenograft procedure

PROJECT_TITLE: Canine Disease and Transplantation Model


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Infertility;Menopause;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE The current K01 application seeks to understand the role of gonadal aging on stress physiology, particularly inflammatory and vascular responses, in order to clarify stress-related pathways that may increase vulnerability towards cardiovascular disease in women. Understanding whether sex hormones mediate these stress- related pathways may inform prevention efforts and treatments for women with heart disease to reduce cardiovascular mortality among women.

PI_NAMEs: SULLIVAN, SAMAAH M (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Adverse effects;Age;Age Years;aged;Aging;Arterial Fatty Streak;atherosclerosis risk;biological adaptation to stress;Biological Markers;biological sex;Biology;Blood Vessels;Cardiovascular Diseases;cardiovascular effects;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;career development;Cause of Death;Clinical;clinical training;Contraceptive Usage;Coronary heart disease;Data;Data Collection;Development;diminished ovarian reserve;Discrimination;disparities in women;Disparity;early life adversity;early onset;emotional factor;Emotional Stress;Enrollment;Environmental Risk Factor;Faculty;Female;Future;Goals;Gonadal Steroid Hormones;Heart Diseases;heart function;Hormone use;Immune;Immune response;Impairment;Infertility;Inflammation;Inflammatory;Infrastructure;Interleukin-6;Ischemia;Laboratories;Measures;Mediating;men;Menopausal Status;Menopause;Mental Depression;Mentors;Midlife women;mullerian-inhibiting hormone;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;neighborhood disadvantage;older women;Outcome;Ovarian;ovarian dysfunction;ovarian reserve;participant enrollment;Pathway interactions;Perimenopause;Physiology;Pregnancy Histories;premature;Premenopause;Prevention;Prognosis;Psyche structure;psychosocial;Psychosocial Stress;psychosocial stressors;Recording of previous events;recruit;Reporting;Reproduction;Reproductive History;Research;Research Project Grants;response;Risk;Risk Factors;Role;Sampling;Severities;Sex Differences;sexual dimorphism;socioeconomic disadvantage;Stress;stress reactivity;Stress Tests;Training;training opportunity;United States;United States National Institutes of Health;Woman;women versus men;Women's mortality;women's outcomes;Women's study;women's treatment;Work;young woman

PROJECT_TITLE: Stress, Vascular Function, and Inflammation as Mechanisms of Sex Differences in Cardiovascular Risk


PROJECT_TERMS: base;Biology;Career Choice;Cells;Charge;Climacteric;Communities;Education and Outreach;Educational process of instructing;Educational workshop;experience;Faculty;Funding;Grant;Hematology;high school;Income;Instruction;Internships;lectures;new technology;Occupations;Positioning Attribute;Postdoctoral Fellow;programs;Progress Reports;Recommendation;Research;Resources;role model;Schedule;Scientist;Secure;Series;Services;Site;stem cells;Structure;Students;Sum;Surveys;System;Techniques;Time;Training;training opportunity;Transplantation;Travel;undergraduate student;Underrepresented Students;Universities;Washington;Work

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

PHR: Narrative Informed by the selective vulnerability of different brain regions to Alzheimer’s Disease (AD) defining tau lesions, this project tests candidate driver genes involved in protein misfolding as well as transcriptional programming. The proposed experiments will provide new insight into AD disease mechanism and provide the foundation for therapeutic development of disease-modifying therapies.

PI_NAMEs: AYOUB, CHRISTOPHER ANTHONY (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Affect;Agonist;Alzheimer's Disease;Alzheimer's disease risk;American;Amyloid beta-Protein;Area;Biochemical;biochemical model;Biological Markers;Biosensor;Brain;brain control;Brain region;burden of illness;Candidate Disease Gene;Cell Culture Techniques;Cerebellum;Cessation of life;circadian;circadian pacemaker;Complex;Data Set;Dementia;Development;Diagnosis;differential expression;Disease;Disease Marker;Disease Progression;disorder risk;Distal;Environment;Etiology;experimental study;Exposure to;extracellular;Foundations;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Transcription;Impaired cognition;In Vitro;in vivo;Individual;Injections;insight;Kinetics;Knockout Mice;Lesion;locus ceruleus structure;Measures;Memory Loss;Micro Array Data;Modeling;Molecular Chaperones;Morbidity - disease rate;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuron loss;neuroprotection;new therapeutic target;Nuclear Receptors;overexpression;Pathologic;Pathology;Patients;Phenotype;Prefrontal Cortex;prevent;Prevention;prion-like;Process;programs;protein aggregation;protein folding;protein misfolding;Proteins;Recombinants;Resistance;response;Role;Senile Plaques;Sleep Disorders;small molecule;Staging;Synapses;tau aggregation;tau Proteins;Tauopathies;Testing;therapeutic development;transcription factor;transcriptome sequencing;transcriptomics;Transfection;Transmission Electron Microscopy;United States;Viral

PROJECT_TITLE: Decoding Selective Vulnerability: Effectors and Regulators of Tau Lesion Spread in Alzheimer's Disease


ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: PROJECT NARRATIVE Controlling glucuronidation is important to public health because it will facilitate the development of novel strategies in drug discovery and also sensitize some drug resistant tumors to existing chemotherapeutics. Controlling human UDP-glucose dehydrogenase is a novel strategy for controlling glucuronidation. This project will shed light on the atypical allosteric mechanism that regulates human UGP-glucose dehydrogenase.

PI_NAMEs: WOOD, ZACHARY ARTHUR (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Active Sites;Affinity;Allosteric Regulation;Allosteric Site;Binding;Binding Sites;Biological Availability;Clinical Trials;Complement;Complex;Coupled;Coupling;Data;Dependence;design;Development;Disease;drug development;drug discovery;Drug Kinetics;Drug Metabolic Detoxication;drug metabolism;Drug resistance;Engineering;Entropy;Enzyme Induction;Enzyme Inhibition;enzyme structure;Enzymes;Failure;Feedback;Foundations;Glucose;glucose dehydrogenase;Glucuronides;Goals;Grant;Human;Hydrogen Bonding;inhibitor;innovation;Isomerism;Kinetics;Learning;Link;Malignant Neoplasms;Membrane Proteins;Modeling;Molecular Conformation;Mutation;Nature;Neutron Diffraction;novel;novel strategies;Outcome;oxidation;Oxidoreductase;Pathway interactions;Pharmaceutical Preparations;Pharmacodynamics;Phase;Protein Engineering;protein function;Proteins;Proteome;Public Health;Research;resistance mechanism;Role;Site;Source;Specificity;Structure;sugar;Tail;Testing;Therapeutic;tool;tumor;Uridine Diphosphate Glucose Dehydrogenase;Uridine Diphosphate Glucuronic Acid;Uridine Diphosphate Xylose;Work

PROJECT_TITLE: The role of intrinsic disorder in the allosteric regulation of human UGDH

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Worldwide nearly 25 million adults are part of a growing population of transgender people. Many transgender adults undergo hormone therapy as one part of the standard of medical care, but the effect of high dose sex hormone therapy on drug safety and efficacy has not been established. This project aims to evaluate the effect of estradiol treatment on the activities of cytochrome P450 3A and P-glycoprotein activities, two key drug handling proteins, to establish the effect of gender-affirming hormone therapy on drug disposition in transgender adults.

PI_NAMEs: CIRRINCIONE, LAUREN  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: ABCB1 gene;Adult;Anti-HIV Therapy;Area;arm;assigned male at birth;burden of chronic illness;Cardiovascular system;career;Caring;Clinic;Clinical;Clinical Pharmacology;clinically significant;Complex;Creatinine clearance measurement;CYP3A4 gene;Cytochrome P450;cytochrome P450 3A;Data;design;Digoxin;Dose;drug disposition;drug efficacy;Drug Interactions;drug metabolism;Drug Prescriptions;Drug Transport;Enrollment;Environment;Enzymes;Estradiol;Estrogen Therapy;Estrogens;experimental study;Female;Funding;gender affirmation;gender affirming hormone therapy;gender diverse;Gender Identity;Gender Role;Goals;Gonadal Steroid Hormones;Grant;health care service utilization;Hepatic;HIV Infections;Hormonal;hormone therapy;Hormones;Hour;Human;In Vitro;in vivo;infection burden;Injectable;inter-individual variation;Intestines;Intravenous;Kidney;Learning;liquid chromatography mass spectrometry;Longitudinal Studies;Mediating;Medical;medication safety;Medicine;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Methods;Midazolam;Modeling;Oral;Outcome;Participant;Pathway interactions;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacology Study;Pharmacy Schools;Physiological;Plasma;Population;Postpartum Period;Pregnancy;Pregnant Women;Procedures;professor;prospective;protein biomarkers;Proteins;Public Health;Regulation;Research Design;Research Personnel;Role;routine therapy;Safety;sample collection;Sampling;Sex Characteristics;Testing;Time;Toxic effect;Training;transgender;transgender women;United States National Institutes of Health;Universities;urinary;Urine;Variant;Visit;Washington;Weight

PROJECT_TITLE: Hormone mediated mechanisms of altered drug metabolism and transport in transgender adults

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Clinical Research;Dystonia;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Dystonic cerebral palsy is the most common cause of functionally debilitating and medically intractable childhood dystonia but its pathophysiology remains understudied. This proposal will use a mouse model of neonatal brain injury to probe whether striatal cholinergic interneurons could serve as a therapeutic target for dystonic cerebral palsy prevention. The award will provide the investigator with the mentored training required for an independent physician-scientist career focused on identifying treatment targets for dystonic cerebral palsy.

PI_NAMEs: ARAVAMUTHAN, BHOOMA  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adult;Affect;Agonist;Animals;Anti-Cholinergics;ARHGEF5 gene;Award;Basal Ganglia;Brain;career;Cerebral Palsy;Child;Childhood;cholinergic;Cholinergic Agents;Chronic;Clinical;clinically relevant;Clozapine;Corpus striatum structure;Data;designer receptors exclusively activated by designer drugs;Dopamine;Dopamine D2 Receptor;Dystonia;Electrophysiology (science);Ensure;Environment;Exhibits;experimental study;Faculty;flu;Functional disorder;Genetic;Goals;Grant;Hypoxia;hypoxia neonatorum;Hypoxic Brain Damage;Implant;In Vitro;in vivo;Injections;Injury;innovation;Institution;Interneurons;Intervention;Ischemia;Jordan;Life;Ligands;Live Birth;Measures;Mediating;Medical;medical schools;Mentors;Mentorship;Modeling;Motor disability;mouse model;multidisciplinary;Mus;Neonatal;Neonatal Brain Injury;Neurology;Neurons;Oxides;Pathology;pediatric dystonia;Pharmaceutical Preparations;Physicians;postnatal;Pregnancy;presymptomatic testing;prevent;Prevention;Preventive treatment;Refractory;Research;Research Personnel;response;Rodent Model;Running;Scientific Advances and Accomplishments;Scientist;Severities;Slice;Testing;Therapeutic;therapeutic target;therapy development;Training;Translational Research;Universities;Viral;Visual;Washington

PROJECT_TITLE: Modulation of striatal cholinergic interneuron activity to prevent dystonic cerebral palsy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE The UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development Program (CDP) aims to nurture junior faculty to become team-driven researchers who are able to conduct patient-oriented cancer research that is enhanced by basic/translational (laboratory) science. This caliber of research - which, for example, identifies biomarkers or optimizes how drugs work - is at the forefront of cancer clinical research and has the highest potential to improve outcomes for patients with cancer. Through this program, exceptional clinical and basic/translational scientists will hone their skills to become leaders in translational, multi- disciplinary research.

PI_NAMEs: LARA, PRIMO N. (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Automobile Driving;Basic Science;cancer clinical trial;Cancer Patient;career;career development;Center for Translational Science Activities;Clinical;clinical investigation;Clinical Oncology Supplement (K12);Clinical Research;Clinical Skills;Clinical Trials;Communication;Competence;Comprehensive Cancer Center;Development;didactic education;Discipline;drug development;drug discovery;Ensure;Environment;Ethics;Evaluation;evidence base;Faculty;FarGo;Funding;Goals;Grant;improved outcome;Infrastructure;innovation;interest;Language;Malignant Neoplasms;medical schools;Mentored Clinical Scientist Development Program;Mentors;Mentorship;multidisciplinary;National Center for Advancing Translational Sciences;Oncology;patient oriented;patient oriented research;Patients;Physicians;Program Development;programs;Research;research and development;Research Design;Research Personnel;Research Project Grants;Research Training;Scholars Program;Science;Scientist;skills;success;Time;Training;Translational Research;translational scientist;Vision;Writing

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Human cells recognize double-stranded RNAs derived from viruses to stimulate immune responses. Double-stranded RNAs are also made from the human genome and need to be regulated to prevent diseases. This proposal aims to understand how double-stranded RNAs are recognized and regulated to ensure cells respond appropriately.

PI_NAMEs: FANG, WENWEN  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Anti-viral Response;Autoimmune Diseases;autoinflammatory diseases;Biochemical;biochemical model;Biogenesis;Biological Process;Cells;Communicable Diseases;Complex;Development;Disease;Double-Stranded RNA;ds RNA-Binding Proteins;Ensure;Genetic screening method;Goals;Human;Human Genome;human model;Immune;Immune response;Immunologic Stimulation;innate immune sensing;insight;Ligands;Malignant Neoplasms;Methods;Microprocessor;MicroRNAs;Modeling;Natural Immunity;prevent;Proteins;Regulation;Research;sensor;single molecule;Structure;Therapeutic;Transcript;Viral;Virus

PROJECT_TITLE: Understanding double-stranded RNA recognition in human cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Chronic Pain;Machine Learning and Artificial Intelligence;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The aim of this project is to identify quantitative relationships which govern the efficacy of post- operative pain management strategies. We will do this by modeling the postoperative evolution of pain score, and by identifying intraoperative correlates of pain state in a large dataset of EHR data from over 100,000 surgical procedures and several thousand intraoperative EEG recordings. This will allow the improvement of postoperative pain management, decreasing opioid usage and improving clinical outcomes, and allow for assessment of pain in patients who are sedated, have altered mental status, or are otherwise unable to self-report.

PI_NAMEs: LIU, RAN  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Absence of pain sensation;Accounting;Acute;Acute Pain;Adverse effects;American;Analgesics;analytical method;Biological Markers;Chronic;chronic pain;Clinical;clinical decision support;cohort;Data;deep learning;Differential Equation;Disease;dosage;Electroencephalography;Electronic Health Record;Evolution;experience;Frequencies;Future;General Hospitals;Goals;Guidelines;Healthcare;improved;Incidence;Individual;Intervention;large datasets;Learning;Length of Stay;Machine Learning;Massachusetts;Measures;mental state;Methods;Modality;Modeling;mortality;neural;non-opioid analgesic;Operative Surgical Procedures;Opioid;opioid abuse;opioid epidemic;opioid sparing;opioid use;opioid use disorder;optimal treatments;Outcome;Pain;Pain management;Pain Measurement;pain model;pain relief;pain score;Patient Self-Report;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Physiological;Policies;Postoperative Pain;Postoperative Period;predicting response;Procedures;Public Health;Recommendation;Recovery;Reporting;Research;response;Risk;Sedation procedure;signal processing;Societies;Statistical Data Interpretation;Time;time use;treatment response;Unconscious State;United States

PROJECT_TITLE: Model-based optimization of pain management in surgical patients


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Immunotherapy;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE In autoimmune endocrine diseases, such as type 1 diabetes or Hashimoto’s thyroiditis, the immune system inappropriately attacks self-tissue, leading to loss of function of hormone- producing cells. Focusing on Hashimoto’s thyroiditis, the most common autoimmune disease, I will use systems immunology to understand how hormone-producing epithelial cells may modulate the immune system and influence whether hormone production is lost. This work may identify new therapeutic targets to prevent and treat autoimmune endocrine disease more broadly.

PI_NAMEs: RENGARAJAN, MICHELLE  (contact)

PROGRAM_OFFICER_NAME: BURCH, HENRY B

PROJECT_TERMS: Address;Affect;American;Antigen Presentation;Antigen-Presenting Cells;antigen-specific T cells;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;autoimmune pathogenesis;autoimmune thyroid disease;Autoimmunity;Autologous;autoreactive T cell;Award;B-Lymphocytes;career;career development;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;Cells;Cellular biology;Clonal Expansion;Communication;cytokine;Data;Dendritic Cells;Development;Development Plans;Disease;Dissection;Endocrine;Endocrine Glands;Endocrine System Diseases;Endocrinology;Environment;Epithelial Cells;Epithelium;Exhibits;experimental study;Five-Year Plans;Funding;Future;General Hospitals;Genes;Genetic Transcription;Global Change;Goals;Graves' Disease;Hashimoto Disease;Health;Hormones;Human;Immune;immune cell infiltrate;immune checkpoint;Immune system;Immunology;immunomodulatory therapies;immunoregulation;In Situ;in vivo;Infiltration;inflammatory milieu;inflammatory modulation;instructor;Insulin-Dependent Diabetes Mellitus;Interferons;Leadership;loss of function;Major Histocompatibility Complex;Massachusetts;medical schools;Medicine;Mentors;Mentorship;MHC Class II Genes;Modeling;monocyte;new therapeutic target;patient retention;Patients;Phenotype;Physicians;Population;Positioning Attribute;preservation;prevent;Process;Production;programs;protein complex;Regulatory T-Lymphocyte;Research;Research Personnel;Resources;response;Role;Scientist;single cell genomics;single nucleus RNA-sequencing;single-cell RNA sequencing;System;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Thyroid Gland;Thyroid Hormones;Thyroiditis;Tissue Preservation;Tissues;Training;Work

PROJECT_TITLE: Modulation of immune cell phenotype by hormone-producing epithelia in autoimmune endocrinopathies

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The goal of this project is to establish a Tissue Mapping Center to identify and characterize senescent cells in human adipose, skeletal muscle, liver, and ovarian tissues across human lifespan as part of the SenNet Consortium, for which the collective goal is to develop a 4D atlas of human senescent cells.

PI_NAMEs: ALIFERIS, CONSTANTIN F.;NIEDERNHOFER, LAURA JANE (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Adipose tissue;age-related disease;aged;Aging;aging population;aging process;Alzheimer's Disease;Architecture;Archives;Atlases;Attenuated;Bioinformatics;Biological;Biological Process;Biology;biomarker identification;Birth;Cell Aging;Cells;Cellular biology;Chairperson;Chromatin;Clinic;Clinical;Clinical Trials;Collaborations;Collection;Communication;Communities;Complex;Computational Biology;Consent;Data;Data Analyses;Data Coordinating Center;Data Discovery;data management;data modeling;Data Science;data sharing;Detection;Disease;DNA Methylation;Electronic Health Record;Embryonic Development;Equipment;Excision;experience;extracellular;FAIR principles;Formalin;frailty;Gene Expression;Generations;Genetic;Genome;Genomics;Goals;healthy aging;Human;Human Resources;Human Subject Research;human tissue;Hypertension;Image;Immune system;Immunology;improved;Informatics;Infrastructure;Institution;Insulin;International;Knowledge;Leadership;Learning;life span;Link;Liver;Maps;Measurement;Measures;Metadata;Minnesota;Modeling;Molecular;Multiplexed Ion Beam Imaging;Mus;Muscle;nano-string;novel therapeutic intervention;Operative Surgical Procedures;Organ;Organism;Ovarian Tissue;Paraffin Embedding;Pathologic;Pathologist;Pathology;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic biomarker;Physiological;Physiology;Plasma;Play;Procedures;Proteomics;Public Health Informatics;quality assurance;Quality Control;Research;Research Personnel;research study;resilience;response;Role;Sampling;senescence;senescence associated secretory phenotype;senescent cell;senolytics;single cell technology;Skeletal Muscle;stressor;subcutaneous;success;synergism;Technology;Therapeutic;therapeutic target;tissue mapping;Tissue Procurements;Tissues;transcriptomics;Tumor Suppression;United States National Institutes of Health;Universities;vastus lateralis;virtual;Visualization;Work;wound healing

PROJECT_TITLE: Minnesota Tissue Mapping Center for Senescent Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: NIEDERNHOFER, LAURA JANE (contact)

PROJECT_TERMS: Adipose tissue;Adoption;Agreement;analytical tool;Atlases;Biological;Biology;Biology of Aging;biomarker discovery;Cell Aging;Cell Count;Cells;Cellular biology;Clinical Data;Collection;Common Data Element;Communication;Consent;Data;Data Analyses;Data Collection;Data Coordinating Center;data dissemination;data exchange;data integration;data management;Data Set;data sharing;data standards;Development;Dimensions;Electronic Health Record;Emerging Technologies;Ensure;Evaluation;experience;Experimental Designs;Funding;Future;Genomics;Goals;Grant;Health;healthy aging;Histology;Home;Human;human tissue;Immunology;Informatics;innovation;innovative technologies;Liver;Maps;meetings;member;Metabolic;Metabolism;Methods;Mining;Minnesota;Muscle;nano-string;National Institute of Environmental Health Sciences;new technology;novel strategies;operation;Organ;Ovarian Tissue;Paper;Pathology;Phenotype;Pilot Projects;Procedures;Production;Productivity;programs;Protocols documentation;Public Health Informatics;Readiness;Reproducibility;Research;Running;Sampling;Scientist;senescence;senescent cell;single cell analysis;Site;skeletal tissue;Software Tools;Specimen;Standardization;synergism;Technology;technology development;Testing;tissue mapping;Tissues;tool;Training;Training Activity;Transfer Agreement;United States National Institutes of Health;Visualization;webinar;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Current imaging technology is not suitable for the high spatiotemporal imaging required for understanding the brain. We propose to develop a single photon avalanche diode based widefield imager to enable the next generation of neuroimaging experiments. We will demonstrate the power of the technology by imaging dendritic activity.

PI_NAMEs: THEOGARAJAN, LUKE SATISH KUMAR (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Unlocking the potential of High-speed widefield Imaging


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: NARRATIVE There is an urgent need to improve chemoradiation therapy for patients with locally advanced cancers. Since effective chemoradiation therapy requires the accumulation of unrepaired DNA damage, targeting cellular DNA damage response (DDR) pathways to prevent efficient DNA repair is a promising approach to enhance the efficacy of chemoradiation therapy. My overall research goal is to develop DDR inhibitory drugs in the laboratory for translation to clinical trials to benefit patients with locally advanced cancers.

PI_NAMEs: PARSELS, LESLIE ANNE (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Antimetabolites;Award;Biological Markers;bioluminescence imaging;Cancer Biology;Cell Cycle Checkpoint;cellular targeting;chemoradiation;Clinic;Clinical Trials;Clinical Trials Design;Collaborations;Combined Modality Therapy;Confocal Microscopy;Conformal Radiotherapy;Data;Defect;Development;DNA Damage;DNA Double Strand Break;DNA fiber assay;DNA Repair;DNA Repair Inhibition;DNA Repair Pathway;Flow Cytometry;Funding;Future;Genetic;Goals;image guided;immune checkpoint blockade;Immunohistochemistry;improved;inhibitor;Innovative Therapy;Laboratories;Locally Advanced Malignant Neoplasm;Malignant Neoplasms;Methodology;Michigan;Modeling;neoplasm immunotherapy;neoplastic cell;Normal Cell;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Pharmacology;Physicians;pre-clinical;preclinical development;prevent;Primary Lesion;protein activation;Protein Analysis;Qualifying;Radiation;Radiation Induced DNA Damage;radiation response;Radiation therapy;Radiobiology;rational design;replication stress;Research;response;Scientist;single cell proteins;Site;skin biopsy;Sorting;standard of care;synergism;targeted biomarker;therapeutic target;Training;Translating;Translations;Treatment Efficacy;treatment response;tumor;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Improving the therapeutic efficacy of chemoradiation by targeting the DNA damage response


NIH_SPENDING_CATS: Aging;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Obesity;Social Determinants of Health;Women's Health Research

PI_NAMEs: IKRAMUDDIN, SAYEED  (contact)

PROJECT_TERMS: Adipocytes;Adipose tissue;Age;age-related disease;aging population;Attenuated;Automobile Driving;bariatric surgery;Benign;Bile fluid;biobank;Biological;biological specimen archives;Biology;Blood;Body Weight decreased;CDKN2A gene;cell type;Cells;Chemistry;Chronic Disease;Clinic;Collection;Confidentiality of Patient Information;Consent;County;Data;Data Analyses;Department chair;Development;Disease;Ensure;Epidemiology;ethical, legal, and social implication;ethnic diversity;Ethnic Origin;Fatty Liver;fatty liver disease;frailty;Freezing;Fresh Tissue;Funding;Gender;Goals;Grant;Health;Health system;healthy aging;Hepatocyte;Hospitals;Human;human tissue;improved;Individual;Infertility;Inflammation;Insulin Resistance;Intervention Studies;intravenous glucose tolerance test;Laboratories;Lesion;life span;Liver;Mammals;Maps;Measures;Medical Records;Medicine;Meta-Analysis;Metabolic;Metabolic syndrome;Metabolism;Minnesota;model organism;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Operative Surgical Procedures;Organ;Organ Donor;Ovarian Tissue;Ovary;Participant;participant enrollment;Pathology;Patient Care;Patient Recruitments;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Process;professor;prospective;Protocols documentation;quality assurance;Quality Control;Race;recruit;Research;Research Personnel;research study;response;Role;sample collection;Sampling;Secure;senescence;senescent cell;senolytics;Serum;Site;skeletal;Skeletal Muscle;Socioeconomic Status;socioeconomics;spatiotemporal;Specimen;stem cells;Stress;Therapeutic;Tissue Banks;tissue mapping;Tissue Sample;Tissues;Transplantation;Tumor Suppressor Proteins;wound healing

PROJECT_TITLE: Biospecimen-Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: DURBAN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF KWAZULU-NATAL

PHR: PROJECT NARRATIVE Despite commendable progress in developing mental health systems in low-and-middle income countries, critical gaps remain, particularly the development of community-based systems of support for people living with severe mental illness (SMIs). This application will adapt and pilot an evidence-based program – Critical Time Intervention – in a South African district in order to determine its feasibility, appropriateness and limited effectiveness in reducing readmission following discharge from acute psychiatric hospitalization. By generating preliminary data on the real-world implementation of an adapted CTI in South Africa, this application seeks to build on an existing foundation of research partnerships and local government collaboration to develop a transitional support intervention that could yield significant and tangible impacts on people living with SMIs in low-resource communities.

PI_NAMEs: BHANA, ARVIN ;JANSE VAN RENSBURG, ANDRÉ  (contact);PETERSEN, INGE

PROGRAM_OFFICER_NAME: CUBILLOS, LEONARDO

PROJECT_TERMS: acceptability and feasibility;Acute;Admission activity;Back;base;Caring;Cohort Studies;Collaborations;Communities;community based care;Community Developments;Community Health Aides;Community Healthcare;community setting;Consolidated Framework for Implementation Research;Continuity of Patient Care;Country;Data;Development;effective intervention;Effectiveness;Effectiveness of Interventions;effectiveness/implementation trial;Ethnography;evidence base;Evidence based intervention;Evidence based practice;Evidence based program;Family;Family Relationship;Foundations;Frequencies;Guidelines;Health;Health system;Homelessness;hospital readmission;Hospitals;implementation facilitators;implementation outcomes;implementation science;implementation strategy;improved;Income;Individual;innovation;inpatient psychiatric treatment;Institution;International;Intervention;intervention effect;intervention program;Local Government;low and middle-income countries;Measures;Mental Health;Methods;Modeling;Municipalities;Nature;Outcome;Outcome Measure;Output;Pathway interactions;peer support;person centered;Personal Satisfaction;Persons;pilot test;prevent;Prevention;primary outcome;Process Measure;Psyche structure;psychiatric inpatient;Psychiatric therapeutic procedure;psychosocial;Psychosocial Assessment and Care;Qualitative Research;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Recurrence;Relapse;Research;Research Project Grants;Resource-limited setting;Resources;secondary outcome;Services;severe mental illness;Shapes;social;social culture;Social Workers;South Africa;South African;South America;stem;Structure;Support Groups;support network;Support System;System;Testing;Time;Training;Training Activity;Trauma;Vulnerable Populations;Work

PROJECT_TITLE: FEASIBILITY AND ACCEPTABILITY OF CRITICAL TIME INTERVENTION TO SUPPORT PEOPLE WITH SEVERE MENTAL ILLNESS FOLLOWING POST-ACUTE HOSPITAL DISCHARGE IN SOUTH AFRICA


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narratives Building on our success in using novel cryoEM methods to obtain the first near-atomic resolution structures of viral genomes, the largest human viral particles, and small (~120 kDa) membrane protein complexes, this continuation project aims to make atomic resolution structure determination a routine practice for large and transiently stable biological complexes, particularly endogenous cellular complexes and in situ structures in viral genome packaging and gene transcription processes. These new methods will enable investigators to place individual components (proteins, nucleic acids and lipids) within the context of the larger assembly and to visualize chemical interactions among the parts of the complex at atomic detail. Broadly, structural studies of various macromolecular complexes enabled by these new methods will lead to atomic models, help to understand their mechanisms of action, inform efforts to rationally design drugs and vaccines, and suggest novel targets for therapeutic intervention.

PI_NAMEs: ZHOU, Z HONG (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Achievement;Actins;Address;Amino Acids;Area;bacteriocin;Binding;Biological;Biological Process;biological systems;Biomedical Research;cell motility;Cell Physiology;Cells;Cellular Structures;Chemicals;Classification;Code;Complement;Complex;Computer Models;Computer software;computerized data processing;Computing Methodologies;convolutional neural network;Cryoelectron Microscopy;Cytoskeletal Filaments;Data;deep learning;density;design;Development;Disease;DNA;DNA Viruses;Double Stranded DNA Virus;Double Stranded RNA Virus;Drug Design;Electrons;Erythrocytes;Flagella;Funding;genetic information;Genetic Transcription;Genome;Geometry;Goals;Heart;Human;Image;In Situ;Individual;Investigation;Learning;Lipids;Macromolecular Complexes;Maintenance;Maps;Mass Spectrum Analysis;Membrane Proteins;Methods;Modeling;Molecular;nanomachine;neural network;new therapeutic target;non-Native;novel;nucleic acid structure;Nucleic Acids;Outcome;particle;polymerization;Polymers;Process;programs;protein complex;protein purification;protein transport;Proteins;Proteome;Proteomics;quantum;rational design;reconstruction;Research Personnel;Resistance;Resolution;RNA;RNA Viruses;Rod;routine practice;Scheme;small molecule;Source;structural biology;Structure;success;Techniques;Testing;Therapeutic Intervention;three dimensional structure;tool;Training;Transcription Process;transmission process;Vaccines;Validation;Viral;Viral Genome;Virus;Virus Assembly;Virus Replication;Visualization;X-Ray Crystallography

PROJECT_TITLE: High-Resolution CryoEM Reconstruction of Large Complexes

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ALIFERIS, CONSTANTIN F. (contact)

PROJECT_TERMS: Address;Adipose tissue;Age;analytical tool;Atlases;Benchmarking;Bioinformatics;Biologic Characteristic;Biological;Biological Assay;Biological Markers;biomedical data science;causal model;Cell model;cell motility;cell type;Cells;Clinic;clinically actionable;Collaborations;Common Data Element;Computer Models;computerized data processing;Custom;Data;Data Analyses;Data Commons;Data Coordinating Center;Data Element;data ingestion;data integration;data management;data quality;Data Set;data sharing;data sharing networks;data standards;Data Storage and Retrieval;data warehouse;design;Development;Disease;Electronic Health Record;Elements;Ensure;ethical, legal, and social implication;Faculty;Future;Generations;Genomics;Goals;Health;health data;health information technology;Health Services;healthy aging;High Performance Computing;Human;human subject;human tissue;Image;Individual;Informatics;Ingestion;innovation;interoperability;Link;Liver;Maps;Measurement;Measures;Metadata;metadata standards;Methods;Mining;Minnesota;Modeling;multiple omics;Muscle;novel marker;Ontology;Ovarian Tissue;Pathway interactions;Patients;Policies;predictive modeling;Preparation;Procedures;Process;Protocols documentation;Quality Control;Readiness;Recommendation;Reproducibility;Research;Resources;Retrieval;Sampling;Science;Secure;Security;senescent cell;Services;skeletal tissue;Software Tools;spatiotemporal;Specific qualifier value;Specimen;System;Systems Biology;technology development;Testing;tissue mapping;Tissues;tool;United States National Institutes of Health;United States National Library of Medicine;Universities;usability;Validation;Visualization;Visualization software;Work

PROJECT_TITLE: Data-Analysis-Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PI_NAMEs: ROBBINS, PAUL D. (contact)

PROJECT_TERMS: 3-Dimensional;Adipocytes;Adipose tissue;Age;Aging;Amino Acid Sequence;analytical tool;Anatomy;Antibodies;antibody conjugate;Architecture;Atlases;Automobile Driving;Biological;Biological Assay;Biological Markers;Biological Models;Blood;Board Certification;CD3 Antigens;Cell Differentiation process;Cell Nucleus;cell preparation;Cells;cholangiocyte;Chromatin;Clinic;Collaborations;Controlled Environment;Data;Data Analyses;Data Set;Detection;detection assay;Development;Diagnostic;digital;Disease;Emerging Technologies;epigenetic clock;Epigenetic Process;Evolution;experience;Gene Expression;Generations;Genome;Genomics;Goals;Gold;granulosa cell;Health;health data;Heavy Metals;Hepatocyte;Heterogeneity;Human;human induced pluripotent stem cells;human tissue;Hydrogen Peroxide;Image;imaging facilities;improved;In Vitro;in vivo;induced pluripotent stem cell;Infrastructure;innovation;interest;Ions;irradiation;life span;Liver;Maps;Mass Spectrum Analysis;Measures;Methods;Minnesota;Modeling;Molecular;Morbidity - disease rate;mortality;nano-string;new technology;novel;Nuclear;Ovarian Tissue;Pathologist;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Phenotype;Physiology;Plasma;pluripotent stem cell differentiation;Population;progenitor;proteogenomics;Proteomics;Quality Control;Reagent;Reproducibility;Resolution;RNA Probes;scale up;screening;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Sensitivity and Specificity;single cell analysis;single nucleus RNA-sequencing;Site;Skeletal Muscle;Source;spatiotemporal;Specimen;Stains;stressor;T-Lymphocyte;Techniques;Technology;temporal measurement;therapeutic target;Time;Tissue atlas;tissue mapping;Tissues;tool;Training;transcriptome;transcriptome sequencing;Universities;web portal;wound healing

PROJECT_TITLE: Biological Analysis Core


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: MADISON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: STEVENS-SOSTRE, WHITNEY ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TITLE: Investigation of the Role of the KCNH Voltage-Gated Potassium Channel Intracellular Domains in Gating


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PI_NAMEs: GEORGE, BRIANNA ELYSE (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TITLE: Early-Life Stress Drives Increased Heroin Vulnerability: Role of D3 Receptors


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Lung;Lung Cancer;Lymphatic Research;Patient Safety

PHR: PROJECT NARRATIVE Appropriate treatment of non-small cell lung cancer is predicated on accurate characterization of cancer spread to lymph nodes, which can occur via endobronchial ultrasound guided transbronchial needle aspiration or surgical mediastinoscopy. While both procedures can confirm the presence of cancer in lymph nodes, their ability to identify the extent of cancer spread has never been compared but has the potential to change treatment decisions and consequently impact quality-adjusted life years. Findings from this study will 1) determine if one procedure is superior to another, 2) examine optimal methods of performing lymph node biopsies, and 3) minimize diagnostic errors, optimize treatment selection, and improve patient outcomes.

PI_NAMEs: RUDASILL, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Affect;Algorithms;aspirate;Benefits and Risks;Biopsy;Cancer Research Network;career;career development;chemotherapy;Chest;Clinical;clinical diagnostics;Cohort Studies;Collection;Combined Modality Therapy;Data;Data Collection;Data Element;Diagnostic Errors;Diagnostic Neoplasm Staging;Disparate;Endosonography;Enrollment;Environment;Evaluation;Excision;experience;Fellowship;Funding;Goals;Health;Health Services Research;Healthcare Systems;Hilar;Image;improved;Infrastructure;Integrated Health Care Systems;Investigation;Knowledge;Literature;Local Therapy;Lung;Lung nodule;lymph node biopsy;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Master of Science;Mediastinal;Mediastinal lymph node group;Mediastinoscopy;Mentors;Mentorship;Metastatic Neoplasm to Lymph Nodes;Methods;Modeling;mortality risk;National Cancer Institute;Needles;Nodal;Non-Small-Cell Lung Carcinoma;Operative Surgical Procedures;Outcome;Outcomes Research;Outpatients;Parents;Pathology Report;Patient Selection;Patient-Focused Outcomes;Patients;Practice Guidelines;Predictive Value;Principal Investigator;Procedures;Process;Prognosis;Public Health Schools;Publishing;Quality of life;Quality-Adjusted Life Years;Radiation;Radiology Specialty;randomized trial;Recommendation;Research;Research Training;response;Risk;Scientist;screening;Selection for Treatments;shared decision making;Staging;Structure;structured data;surgery outcome;Testing;Thoracic Oncology;Thoracic Surgeon;Time;Training;Training Programs;treatment optimization;trial comparing;ultrasound;Universities;Unnecessary Surgery;Washington

PROJECT_TITLE: Optimizing treatment decisions and quality-adjusted life years through improved lung cancer staging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Buffalo, New York, the second largest city in New York State (population 278,349), experiences disturbing race-based health inequities that shorten the lifespan and reduce quality of life for people of color who reside in predominantly African American neighborhoods on the East Side of Buffalo. Community leaders and stakeholders from multiple sectors of the Buffalo community have created an enduring community-university- government partnership that has enormous reach and influence throughout the community, positioning us to disseminate research findings to promote sustainable system-level change. The goal of our University at Buffalo NIMHD Center of Excellence in Investigator Development and Community Engagement is to train and develop the next generation of health disparities investigators to perform innovative research in minority health and health disparities in partnership with our community and to the benefit of the community.

PI_NAMEs: MURPHY, TIMOTHY F (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Advisory Committees;African American;African American population;American;Architecture;Area;Arts;Biometry;career;Chronic;Cities;Clinical Sciences;Communities;community academic partnership;community collaboration;community engagement;Community Health;community partners;community partnership;Complex;County;Creativeness;Dental;Development;Discipline;Discipline of Nursing;Disease;Diverse Workforce;Environment;Equity;experience;Faculty;Faith leader;Foundations;Generations;Goals;Government;Grant;Growth;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;health outcome disparity;Health Personnel;Health Sciences;improved;Individual;Inequity;Influentials;innovation;Knowledge;Latinx;Laws;Leadership;Life Expectancy;life span;Link;Medicine;meetings;member;Mentors;metropolitan;minority health;minority health disparity;Minority Health Research;Mission;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;next generation;Outcome;people of color;Pharmacy facility;Pilot Projects;Policy Maker;Population;Population Heterogeneity;Positioning Attribute;Public Health;Quality of life;Race;Research;Research Design;Research Institute;Research Personnel;response;Schools;Science;Scientist;Side;social health determinants;Social Work;statistics;Statutes and Laws;Structural Racism;System;Testing;Training;Translating;Translational Research;Universities;Work;Writing

PROJECT_TITLE: Igniting Hope in Buffalo New York Communities: Training the Next Generation of Health Equity Researchers

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (J1)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;African American;Basic Science;Big Data Methods;career;Chronic;Collaborations;Communication;Communities;community collaboration;Community Developments;community engagement;Community Health;Community Participation;Death Rate;Development;Discipline;Disease;Disparity;disparity reduction;Economics;Education;Ensure;Environment;Epidemiology;Evaluation;Faculty;Government;Health;Health Disparities Research;health disparity;health equity;Health equity research;health inequalities;Healthcare;improved;Influentials;innovation;Intervention;Laws;Leadership;marginalization;meetings;member;Mentors;minority health;minority health disparity;Minority Health Research;Mission;Monitor;National Institute on Minority Health and Health Disparities;Needles;Neighborhoods;New York;next generation;Outcome;people of color;Persons;Pilot Projects;Policies;Policy Developments;Procedures;Process;Productivity;Race;Reporting;Research;Research Institute;Research Personnel;Resources;Schools;social health determinants;Social Justice;Social Well-Being;Social Work;Structure;synergism;System;Testing;Training;Universities;urban planning;Vision;Work

PROJECT_TITLE: Igniting Hope in Buffalo New York communities: Training the Next Generation of Health Equity Researchers


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Accounting;Address;Affect;Area;Award;career;Chronic Disease;Cities;Communication;Communities;community based participatory research;community engagement;design;Development;Dimensions;Discipline;Discrimination;Diverse Workforce;Elements;Environment;equity, diversity, and inclusion;ethnic minority;experience;Extramural Activities;Face;Faculty;Foundations;Funding;gender minority community;Generations;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;health inequalities;Individual;innovation;insight;Institution;Institutional Racism;Interdisciplinary Study;Intervention;Lead;Life Expectancy;Lived experience;low socioeconomic status;member;Mentors;Methodology;Minority;minority health;minority health disparity;Minority Health Research;multidisciplinary;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;next generation;Outcome;Patient-Focused Outcomes;people of color;Persons;Pilot Projects;Policies;Policy Making;Population;Postdoctoral Fellow;practice setting;programs;Quality of life;Race;racial minority;Racial Segregation;racism;Research;Research Design;Research Institute;Research Personnel;Resources;Rural Community;rural underserved;Science;Sexual and Gender Minorities;Side;skills;social health determinants;Statistical Data Interpretation;Structural Racism;Structure;tool;Training;Training and Education;Training Programs;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;Vision;Work


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SILVERMAN, ROBERT  (contact)

PROJECT_TERMS: Address;Advisory Committees;African American;Collaborations;Communication;Communities;community based participatory research;community based research;community building;community engagement;community organizations;Community Participation;community partners;community partnership;Data;design;Development;Encapsulated;Equity;experience;Funding;Future;Goals;Government;Grant;health disparity;health equity;health inequalities;Inequity;Infrastructure;Institution;interest;Link;Literature;Measurable;member;National Institute on Minority Health and Health Disparities;Neighborhoods;New York;next generation;Persons;Pilot Projects;Policies;Policy Maker;Research;Research Design;Research Personnel;service organization;social health determinants;Social Responsibility;System;Techniques;Training;Translating;Translations;Universities;Vision;Work


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE The hypothalamus is a highly conserved region of the vertebrate brain that regulates vital survival functions including eating, drinking, metabolism, sleeping, growth, development, fertility, stress, and reward. Dysfunction of the hypothalamus causes a number of disorders and diseases that collectively cost billions of dollars for care and treatment. The goal of this interdisciplinary conference is to bring a diverse group of scientists together to showcase their latest findings, share insights and research strategies, and establish discussion and collaboration across fields.

PI_NAMEs: CARTER, MATTHEW E (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Address;Animals;Anxiety;Area;Basic Science;Behavior;Biological;Biological Process;Brain;career;Caring;Cell Nucleus;cell type;Cells;Circadian Rhythms;Clinical;Clinical Research;Collaborations;college;Communities;Complex;cost;data integration;Development;Discipline;Disease;diversity and inclusion;doctoral student;drinking;Eating;Environment;experimental study;Exposure to;Feeding behaviors;Fertility;Fertilization;Functional disorder;gain of function;gene editing technology;Generations;Genes;Genetic Techniques;Goals;graduate student;Growth;Health;Health behavior;Heterogeneity;Human;Hypothalamic dysfunction;Hypothalamic structure;Imaging Techniques;insight;Interdisciplinary Study;interest;Investigation;Journals;Laboratories;Location;loss of function;meetings;Mentorship;Metabolism;Methods;millimeter;model organism;Molecular;neural;Neurons;neuropsychiatry;Neurosecretory Systems;neurotransmitter release;novel;novel strategies;operation;optogenetics;Peer Group;Physiologic Thermoregulation;Physiological;Population;Postdoctoral Fellow;programs;Proteins;Publishing;recruit;Regulation;Research;Research Personnel;Resource Sharing;Rewards;Role;Schedule;Scientist;Signal Transduction;Sleep;Sleep Disorders;Social Interaction;Stream;Stress;Structure;supportive environment;symposium;System;Techniques;Therapeutic;Training;transcriptomics;Translational Research;Work

PROJECT_TITLE: 2024 Hypothalamus Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (J3)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Pediatric;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative The palmoplantar or glabrous epidermis is uniquely adapted to the greater mechanical stress it experiences in daily life, as compared to other body sites, and is characterized by a specific pattern of keratin intermediate filament (IF) expression including the glabrous-specific keratin 9 and the stress-inducible keratin 16. Keratin 9 levels are remarkably low in embryonic mice, despite abundant expression in adult mouse and human glabrous skin, and mice lacking keratin 9 develop thick glabrous lesions. This proposal will identify the temporal and spatial dynamics and role of keratin 9 expression during early postnatal life and investigate the contribution of mechanical stress, specifically tension and compression, to homeostasis in this unique epidermal location.

PI_NAMEs: STEINER, SARAH N (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Role and regulation of a differentiation-specific keratin in keratinocyte adaptation to mechanical stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The absence of pigment caused by oculocutaneous albinism type 1 (OCA1) tyrosinase mutations leads to detrimental effects on ocular function, including blindness, severe light sensitivity, and, for reasons that are incompletely understood, improper neural retina development. There are no effective treatments to improve vision in patients with OCA1, making OCA1 therapeutic development a critical scientific priority. In this proposal, I aim to develop a gene therapy that alleviates the ocular effects of OCA1 for future clinical use and then leverage this approach to gain insight into the mechanisms of albinism-related retinal maldevelopment.

PI_NAMEs: LARIMER-PICCIANI, ALESSANDRA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: adeno-associated viral vector;Affect;Albinism;Alleles;biomaterial compatibility;Blindness;Buffers;Calcium;Candidate Disease Gene;cell type;Clinical;clinical application;Data;delivery vehicle;Development;Disease;Disparity;effective therapy;Embryo;Enzymes;exome sequencing;experience;experimental study;Eye;Eye Development;Eye diseases;fovea centralis;Frequencies;Functional disorder;Future;Gene Delivery;gene replacement;gene therapy;Gene Transduction Agent;Goals;Hair;Human;Hypopigmentation;improved;in vivo evaluation;Individual;inflammatory marker;Inherited;insight;Ipsilateral;Knowledge;Lead;Light;Link;Macaca;Macaca mulatta;malformation;Maps;Measures;Mediating;Melanins;Melanogenesis;Mentorship;Modeling;Molecular;Monophenol Monooxygenase;Morphology;mouse model;Mus;Mutation;Neural Retina;neurogenesis;nonhuman primate;novel;ocular imaging;Oculocutaneous Albinism;Oculocutaneous albinism type 1;Operative Surgical Procedures;Paracrine Communication;Pathologic Nystagmus;Pathway interactions;Patients;Phenotype;Photophobia;Photosensitivity;Physicians;Pigment Epithelium;Pigments;Preparation;Production;Proteins;Quality of life;Research;Research Personnel;Resolution;Retina;Retinal Diseases;Retinal Ganglion Cells;Route;Safety;Scientist;single-cell RNA sequencing;Site;Skin;Structure;Structure of retinal pigment epithelium;Testing;Therapeutic;therapeutic development;therapeutic evaluation;Time;tool;Training;transcriptomics;vector;Viral Vector;Vision;Visual Acuity;Wild Type Mouse;Work

PROJECT_TITLE: Advancing treatment and molecular understanding of oculocutaneous albinism through gene therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


PHR: PROJECT NARRATIVE Current long term care for stroke is primarily limited to treatments designed to prevent stroke recurrence and to rehabilitation therapies, but many stroke survivors do not recover full function for normal activities. Thus, a major challenge for stroke treatment is the identification of therapeutic strategies that can help restore function and limit long term disability. In this application we identify pathways and potential interventions that can promote long term functional recovery.

PI_NAMEs: ANTONETTI, DAVID ;LAWRENCE, DANIEL A (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Acute;acute stroke;Adult;Affect;Age;Alteplase;angiogenesis;antagonist;Astrocytes;Binding;Biological Assay;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Blood Volume;blood-brain barrier permeabilization;Brain;Brain Injuries;Brain Ischemia;brain tissue;Caring;Cell Culture Techniques;Cell division;Cell membrane;Cell Proliferation;Cells;Central Nervous System;Centrosome;Cerebral hemisphere hemorrhage;cerebrovascular;Cerebrovascular Circulation;comorbidity;comparative efficacy;Complex;Data;disability;Dynein ATPase;Early Intervention;Early treatment;Endothelial Cells;Endothelium;Event;Fibroblast Growth Factor;Flow Cytometry;functional restoration;Funding;Gene Deletion;Gene Expression;glial activation;Goals;Grant;Growth;healing;Imatinib;improved;improved outcome;Infarction;Inflammation;Injury;Intervention;Intravenous;Ischemic Stroke;Leucocytic infiltrate;Light;Link;Location;Long term disability;long term recovery;Long-Term Care;Measures;Mechanics;Mediating;Middle Cerebral Artery Occlusion;Minus End of the Microtubule;Mitotic;Molecular;Motor;Movement;Mus;mutant;Mutation;neuroinflammation;Neurological outcome;neurovascular unit;Neutrophil Infiltration;novel;occludin;Pathway interactions;Patients;Permeability;Phase;Phase II Clinical Trials;Phase III Clinical Trials;Phosphorylation;Phosphorylation Site;Platelet Activation;Platelet-Derived Growth Factor alpha Receptor;platelet-derived growth factor C;Platelet-Derived Growth Factor Receptor;Play;post stroke;prevent;Prognosis;Proliferating;protein kinase C beta;Proteins;Publishing;Recovery;Recovery of Function;Recurrence;Regulation;Rehabilitation therapy;Reporting;Research;Resolution;restoration;Role;Severities;Side;Signal Induction;Signal Transduction;Site;Stains;Stroke;Stroke prevention;stroke recovery;stroke survivor;stroke therapy;systematic review;Testing;Therapeutic;therapy design;Thrombectomy;Tight Junctions;Time;Tissues;trafficking;transcriptomics;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Vascular Endothelium;Work

PROJECT_TITLE: Unraveling the role of tPA in the neurovascular unit

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Bitter taste in the oral cavity serves as an aversive warning signal, yet we regularly consume bitter food and medicine. In the gut, bitter molecules control digestive function and appetite, but the gut sensory pathway for bitter signals has not yet been determined. This proposal will deﬁne how chemosensory signals from bitter molecules are detected in the gut and transmitted to the brain.

PI_NAMEs: REICHER, NAAMA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Affect;Afferent Neurons;alpha-gustducin;Animals;Apical;Behavior Control;Binding;Biological Assay;Brain;Calcium;Cell Culture Techniques;Cells;cellular transduction;Cholecystokinin;Cholecystokinin Receptor;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Consumption;Data;Desire for food;Diet;Eating;Electrophysiology (science);Endotoxins;Enteroendocrine Cell;Environment;Epithelial Cells;Esthesia;Family;Feeding behaviors;Fellowship;Food;food consumption;G-Protein-Coupled Receptors;Gastrointestinal tract structure;Goals;gut-brain axis;Health;Image;In Vitro;Individual;Infusion procedures;Ingestion;Intake;intestinal epithelium;Intestines;Knock-out;Laboratories;Measures;Medicine;millisecond;Mus;National Research Service Awards;Nerve;Neurons;Nutrient;optogenetics;Oral cavity;Organoids;Pathway interactions;Pattern;Peptides;pharmacologic;Physiology;Population;Postdoctoral Fellow;preference;Propylthiouracil;Quinine;rapid detection;receptor;receptor expression;Receptor Signaling;Research Personnel;response;Role;sensor;Sensory;sensory stimulus;Signal Pathway;Signal Transduction;Signaling Molecule;Small Intestines;Stimulus;sugar;Sweetening Agents;Synapses;Taste Buds;Taste Perception;taste transduction;Testing;Time;Tissues;Toxin;transmission process;United States National Institutes of Health;Vagus nerve structure;Work

PROJECT_TITLE: F32 - Bitter chemosensation from gut to brain

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Pediatric

ORG_CITY: LA JOLLA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Late first language acquisition of a sign language for deaf individuals has dramatic and lifelong effects on communicative competence as well as education and quality of life with late first language signers at risk of trauma, cognitive delays, mental health struggles, and an inability to obtain employment. While previous research has shown effects on language at the word and sentence levels, more research is needed to understand the effects at every level including the sub-word or phonological level. This project will not only provide a better understanding of how late first language signers process phonology behaviorally and neurolinguistically, but it will also uncover crucial knowledge about how deaf individuals communicate when language acquisition is atypical and provide deeper insight into the relationship between the brain and behavioral outcomes for normal function and disordered processes.

PI_NAMEs: NIELSON, SHAI LYNNE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;Affect;Age;American Sign Language;Area;Articulation;Behavior;Behavioral;behavioral outcome;Birth;Brain;Categories;Child;Childhood;Cognition;Cognitive;Communication;Communication impairment;Competence;critical period;Data;deaf;Disease;early childhood;Education;Employment;Exhibits;Exposure to;extrastriate visual cortex;Family;functional plasticity;Goals;graduate student;Hearing;high risk;Human;improved;Individual;infancy;insight;Investigation;Judgment;Knowledge;Language;Language Development;language outcome;language processing;Late Effects;Location;Manuals;Mental Health;Movement;neuroimaging;Neurologic;Occupations;Parents;Pattern;Perception;phonology;prevent;Process;Production;Productivity;Quality of life;Research;Research Personnel;Research Training;Risk;Semantics;Sign Language;System;Time;Trauma;Visual;visual processing;Work

PROJECT_TITLE: Effects of late first language acquisition on phonological processing in American Sign Language

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (32)]


PHR: NARRATIVE Traditionally understudied, proteoglycans play a crucial role in modulating critical cellular processes, including cellular differentiation, proliferation, growth, adhesion, migration, autophagy, angiogenesis, and survival under developmental, physiological, and pathological conditions. The 2024 Proteoglycans GRC and GRS will highlight the latest findings in fundamental and translational proteoglycan research, new technologies that will foster advancements in the field, and will underscore proteoglycans as therapeutic tools and targets. With a strong history as a meeting with a collegial atmosphere that fosters collaborations among PG scientists, this conference will inspire the next generation of PG researchers and facilitate discussions leading to the generation of new ideas, innovative research projects, new grant proposals, and potential therapeutic strategies targeting proteoglycans.

PI_NAMEs: PANITCH, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Academy;Acceleration;Address;Adhesions;Advisory Committees;Anabolism;angiogenesis;Applications Grants;Area;Arthritis;Attention;Autophagocytosis;Award;Bacterial Infections;biomacromolecule;Blood Vessels;cancer diagnosis;cancer therapy;career;career development;Catabolism;Cell Differentiation process;Cell Physiology;Clinical;Collaborations;Communicable Diseases;Complex;Core Protein;Data;design;Development;Disaccharides;Discipline;Disease;Disease Outcome;educational atmosphere;empowerment;Engineering;Ensure;Environment;Evolution;experience;Fibrosis;Fostering;frontier;Gender;gender equality;Generations;Glycosaminoglycans;Goals;graduate student;Growth;Health;Homeostasis;Hour;Human;Hyaluronan;Immune response;improved;Inflammation;innovation;Institution;International;Knowledge;Location;Machine Learning;Malignant Neoplasms;meetings;Mentors;Mentorship;Methodology;migration;Musculoskeletal;Musculoskeletal System;Nervous System;Nervous System Disorder;new technology;next generation;novel therapeutic intervention;Oral;Participant;Pathologic;Pathologic Processes;Physiological;Physiological Processes;Play;Postdoctoral Fellow;posters;Private Sector;Privatization;Productivity;programs;Proliferating;Proteoglycan;Recording of previous events;Research;Research Personnel;Research Project Grants;Role;Science;Scientist;Sepsis;Sickle Cell Anemia;Signal Transduction;Skin;skin disorder;Societies;Structure;success;symposium;Techniques;Technology;Therapeutic;Time;tissue regeneration;Tissues;tool;translational study;Travel;treatment strategy;Underrepresented Populations;Virus Diseases;Work;wound healing

PROJECT_TITLE: Proteoglycans Gordon Research Conference and Seminar

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]