NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative Graft-versus-host disease (GvHD) is a serious, and unfortunately common, complication of allogeneic hematopoietic cell transplantation (allo-HCT). Although allo-HCT can potentially be curative for a variety of malignant (e.g. leukemia, lymphoma) and non-malignant (e.g. anemia, immunodeficiencies) diseases, continued research is critical for the development of novel methods of mitigating the debilitating consequences of GvHD. This proposal builds on the discovery I made using mouse models that Galectin-3 from donor and host cells protects normal tissues from GvHD resulting in decreased severity and mortality and may determine the therapeutic potential and cellular mechanisms by which Galectin-3 inhibits GvHD following allo-HCT.

PI_NAMEs: MOHAMMADPOUR, HEMN  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Graft Versus Host Disease;adaptive immunity;Advisory Committees;Affect;Allogenic;Anemia;anti-PD1 therapy;Antigen-Presenting Cells;Aplastic Anemia;Biological Markers;Biology;biomarker identification;Body Weight;Bone Marrow;cancer therapy;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Clinical;Clinical Trials;Complication;curative treatments;cytokine;Cytoprotection;Data;Development;Disease;effector T cell;Engraftment;experimental study;Family;Fibrosis;FOXP3 gene;Galactose Binding Lectin;Galectin 3;Goals;graft vs host disease;Graft-Versus-Tumor Induction;Heart Diseases;Hematopoietic;Hematopoietic Stem Cell Transplantation;HLA-A2 Antigen;Human;Immune;immune reconstitution;Immune System Diseases;immunodeficiency;Immunotherapy;Impairment;improved;Incidence;Infection;inhibitor;Injections;insight;Knowledge;Lectin;leukemia;Lymphoma;Macrophage;Malignant - descriptor;Malignant Neoplasms;Measures;Mentors;Methods;Modeling;mortality;mouse model;Mus;Myeloid Cells;Natural Immunity;Non-Malignant;Normal tissue morphology;novel;novel strategies;novel therapeutics;Outcome;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Phase;Plasma;Play;Postdoctoral Fellow;preservation;prevent;Production;prognostic;Prospective Studies;Reagent;Recombinants;reconstitution;Regulatory T-Lymphocyte;Relapse;Research;Research Personnel;response;Risk;Role;Severities;Severity of illness;Sickle Cell Anemia;side effect;Signal Transduction;skills;Supervision;System;T memory cell;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;therapeutic target;Tissue Grafts;Tissues;Training;transplant model;Transplant Recipients;tumor;Work;Xenograft procedure

PROJECT_TITLE: Implication of Galectin-3 to regulate Graft vs. Host Disease (GvHD) and Graft vs. Tumor (GVT) Responses

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PI_NAMEs: MILES, MICHAEL F (contact)

PROJECT_TERMS: Advisory Committees;alcohol behavior;alcohol research;Behavioral;Bioinformatics;Budgets;Collaborations;Communication;Communities;data management;data quality;data sharing;Development;Educational process of instructing;Ensure;Extramural Activities;Fostering;gene network;Goals;Investigation;Leadership;meetings;Monitor;outreach;Pilot Projects;Productivity;programs;Quality Control;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Literature;Rodent;Science;Scientist;Series;Structure;student training;Supervision;synergism;Universities;Virginia

PROJECT_TITLE: Core 1: Administrative Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dietary Supplements;Genetics;Neurosciences;Nutrition;Prevention;Substance Misuse

PI_NAMEs: WOLSTENHOLME, JENNIFER T (contact)

PROJECT_TERMS: Acute;Alcohol abuse;alcohol abuse therapy;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol response;alcohol risk;alcohol seeking behavior;alcohol sensitivity;alcohol testing;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholism;Alcohols;Animal Model;Animals;Anti-Anxiety Agents;Behavior;Behavior assessment;behavior test;Behavioral;behavioral outcome;Behavioral Paradigm;behavioral phenotyping;behavioral response;Bioinformatics;Biological Models;Brain;Brain region;Caenorhabditis elegans;Candidate Disease Gene;Cells;chronic alcohol ingestion;Collaborations;Complex;Constitution;Consumption;Data;design;Development;Diagnosis;Diet;dietary;dietary manipulation;Disease;Dose;Drosophila genus;endophenotype;Environment;Environmental Risk Factor;Ethanol;Exhibits;fly;Future;gene environment interaction;Gene Modified;gene network;Genes;Genetic;genetic manipulation;Goals;Grant;Human;hypnotic;improved;Individual;insight;Invertebrates;Investigation;Knowledge;Mediating;model organism;Modeling;Molecular;Motor;Mouse Strains;Mus;Nervous System;neural circuit;Neurobiology;new therapeutic target;Omega-3 Fatty Acids;Organism;Phenotype;Pilot Projects;Predisposition;Prevention;Rattus;response;Risk Marker;Rodent;Role;Sedation procedure;Seizures;Signal Pathway;Stimulant;Stress;Testing;therapy development;transgene delivery;Transgenic Mice;Translating;Validation;Viral;Viral Vector

PROJECT_TITLE: Core 2: Rodent Behavioral Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Discerning neurodegenerative disease pathomechanisms have been challenging due to disease polygenicity, largely unknown etiology, and the involvement of multiple cell types. This proposal implements multispectral imaging (MSI) as a feasible, innovative, and unbiased approach to investigating the cellular physiology of neurodegenerative diseases in disease-relevant cell types. Applying this systems-level approach to neurons and astrocytes will enhance our understanding of TDP-43 proteinopathies, namely frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).

PI_NAMEs: RHOADS, SHANNON  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: 3-Dimensional;Affect;ALS patients;Amyotrophic Lateral Sclerosis;analysis pipeline;Astrocytes;Automobile Driving;Binding;Brain;brain cell;brain tissue;Cell Physiology;cell type;Cells;Cessation of life;Characteristics;Clinical;Computational Biology;Confocal Microscopy;Data;Dementia;Disease;Disparate;DNA-Binding Proteins;effective therapy;Endoplasmic Reticulum;Etiology;Fibroblasts;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genes;Genetic;Goals;Golgi Apparatus;Health;Human;human induced pluripotent stem cells;Image;imaging modality;improved;Induced Mutation;Induced pluripotent stem cell derived human neuron;innovation;Label;Lead;Link;Lipids;Lysosomes;Membrane;Methods;Microscopy;Mitochondria;Morphology;Muscular Atrophy;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel strategies;Organelles;Pathogenesis;Pathogenicity;Pathologic;Pathology;peroxisome;pharmacologic;Phenotype;Physiological;Physiology;Population;Process;protein aggregation;protein TDP-43;response;sample fixation;Series;spatiotemporal;spectrograph;stressor;success;System;Techniques;Testing;Time;trafficking;training opportunity;Visualization;Work

PROJECT_TITLE: Multispectral Imaging of Neurons and Astrocytes: Revealing Spatiotemporal Organelle Phenotypes in Health and Neurodegeneration


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Substance Misuse

PI_NAMEs: BACANU, SILVIU-ALIN  (contact)

PROJECT_TERMS: Acceleration;Address;alcohol behavior;alcohol research;alcohol use disorder;Alcohols;Animal Model;Animals;Big Data;Bioinformatics;bioinformatics network;comorbidity;complex data;computerized data processing;Data;Data Collection;data curation;data handling;data imputation;data integration;Data Management Resources;data mining;Data Set;data sharing;Disease;Ensure;Equation;Exclusion;exome;Experimental Designs;fly;Gene Expression;gene network;Genes;Genetic;genetic analysis;Genome;genome wide association study;genomic data;Goals;Human;Human Genome;Individual;Investigation;Methods;model organism;Modeling;Mus;novel;Organism;Pathway Analysis;Pattern;Phenotype;phenotypic data;Pilot Projects;Play;Process;protein protein interaction;repository;Research Design;Research Personnel;RNA analysis;Role;Single Nucleotide Polymorphism;Source;statistics;support network;tool;trait;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Core 3: Bioinformatics and Analysis Core


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: TAMPA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative  The proposed study will investigate the functional role and lineage contribution of a novel population of blood vessel progenitor cells which we have identified in zebrafish embryos. These cells contribute to vascular growth by a novel mechanism of intercalation into existing vasculature. The acquired knowledge will promote development of new therapeutic strategies aimed at repairing damaged vessels in multiple vascular diseases.

PI_NAMEs: SUMANAS, SAULIUS  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Ablation;angiogenesis;Atherosclerosis;Biological Models;Blood Vessels;Cells;Circulation;Data;Defect;defined contribution;Development;Diabetes Mellitus;Dyslipidemias;Embryo;Embryonic Development;Endothelial Cells;endothelial stem cell;Endothelium;Fluorescein;Genes;Genetic;Genetic Recombination;Growth;Hematopoietic;Human;Hypertension;Image;Immunohistochemistry;in vivo;injury and repair;Intercalated Cell;intercalation;Ischemia;junctional adhesion molecule;Knowledge acquisition;Mammals;Methods;Molecular;Molecular Analysis;monolayer;Mus;mutant;Natural regeneration;novel;novel therapeutic intervention;Organ;Phenotype;Play;Population;progenitor;Pronephric structure;Recovery;repaired;Reporter;Reporter Genes;Role;Signal Pathway;Site;Source;Specific qualifier value;stem cells;Testing;Therapeutic;therapeutically effective;Tissues;transcription factor;Transgenic Organisms;vascular contributions;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelial Growth Factors;Vascular Endothelium;Vascular regeneration;vasculogenesis;Vasculogenic;Venous;Venus;Vertebrates;Zebrafish

PROJECT_TITLE: Novel mechanisms of vasculogenesis

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Substance Misuse

PROJECT_TERMS: Acute;Advisory Committees;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol research;alcohol response;alcohol risk;alcohol sensitivity;alcohol use disorder;Amides;Applications Grants;Cannabinoids;Clinical Trials;Cognitive;cognitive performance;comorbidity;Data;data integration;Dependence;Development;disorder risk;Dissection;Drug abuse;Drug Modelings;Drug Use Disorder;Emotions;Enzymes;executive function;experience;FAAH inhibitor;fatty acid amide hydrolase;Fatty Acids;Funding;Future;gene network;Genetic;Genetic Markers;Genetic study;genomic data;Goals;Grant;Human;Individual;inhibitor;innovation;Intake;interest;Intoxication;Investigation;Knock-out;Knowledge;Laboratories;Lead;Lipids;Metabolic;Modeling;Molecular;Motivation;NAPE-PLD;neurobehavioral;Neurocognition;Neurocognitive;novel;Online Systems;parent grant;Participant;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Population Heterogeneity;Postdoctoral Fellow;PPAR alpha;PPAR gamma;preference;programs;Quality Control;Rattus;Research;Research Personnel;Risk;Role;Sampling;Signal Transduction;Solid;Standardization;Students;synthetic enzyme;Testing;training opportunity;Training Support;Work

PROJECT_TITLE: Core 4: Pilot Project Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Kidney Disease;Nutrition;Obesity;Pediatric;Polycystic Kidney Disease

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The proposed clinical trial will determine whether a daily-caloric restriction-based weight loss intervention can slow kidney growth in adults with autosomal dominant polycystic kidney disease who are overweight or obese. The study will also evaluate changes in abdominal fat by magnetic resonance imaging. Blood and fat samples will provide insight into biological changes that may contribute to any observed benefits of the intervention.

PI_NAMEs: NOWAK, KRISTEN LYNN (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: 5'-AMP-activated protein kinase;Abdomen;abdominal fat;acceptability and feasibility;Adherence;Adipocytes;adipokines;adiponectin;Adipose tissue;Adult;adult obesity;Affect;Anti-Inflammatory Agents;Autosomal Dominant Polycystic Kidney;Behavioral;Biological;Biological Markers;Blood;Body fat;Body mass index;Body Weight decreased;C-reactive protein;Caloric Restriction;Chronic;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Trials;comparative efficacy;Control Groups;cost;Cyst;Cystic kidney;cytokine;Data;Defect;Development;dietary;Disease;Disease Management;Disease Progression;efficacy evaluation;End stage renal failure;Endocrine Glands;Epithelium;Fatty acid glycerol esters;Feasibility Studies;food restriction;FRAP1 gene;functional decline;Funding;General Population;Genetic Diseases;Growth;Height;Hereditary Disease;IGFBP1 gene;improved outcome;Individual;Inflammatory;inflammatory marker;insight;Insulin-Like Growth Factor I;Interleukin-6;Intervention;Kidney;Kidney Diseases;Leptin;Life;lifestyle intervention;Link;Liquid substance;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Mediating;Metabolic;Metabolism;novel;Obesity;Overweight;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Pilot Projects;primary outcome;Proliferating;Randomized Controlled Clinical Trials;Recommendation;Renal function;Reporting;Ribosomal Protein S6 Kinase;Rodent Model;Safety;Sample Size;Sampling;secondary outcome;Serum;side effect;Signal Pathway;Signal Transduction;STAT3 gene;subcutaneous;systemic inflammatory response;Tissues;tolvaptan;Translating;tumorigenic;Visceral;Visceral fat;weight loss intervention

PROJECT_TITLE: Daily Caloric Restriction in Overweight and Obese Adults with ADPKD

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Substance Misuse

PROJECT_TERMS: 3-Dimensional;Affect;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol research;alcohol sensitivity;alcohol use disorder;Alleles;Animals;Behavior;Behavioral;Behavioral Genetics;behavioral genomics;behavioral phenotyping;behavioral study;Bioinformatics;Breeding;Caenorhabditis elegans;Candidate Disease Gene;candidate validation;Chromatin;Collaborations;Complex;Consumption;CRISPR/Cas technology;Data;Detection;Distal;drinking;Drosophila genus;Ethanol;Ethanol Metabolism;experimental study;Funding;Future;gene discovery;Gene Expression;gene network;Gene Targeting;Genes;Genetic;genetic analysis;Genetic study;Genetic Variation;genome wide association study;genome-wide;genomic data;genomic locus;Genomics;Genotype;Haplotypes;Heavy Drinking;Heritability;Heterozygote;Human;Human Genetics;Human Genome;Injections;Intake;Invertebrates;Investigation;knock-down;Laboratories;LoxP-flanked allele;Maps;Meta-Analysis;Modeling;Molecular Conformation;Morbidity - disease rate;mortality;mouse genetics;Mouse Strains;Mus;novel;Nucleus Accumbens;overexpression;Pathway Analysis;Phenotype;Phylogeny;Play;Prefrontal Cortex;progenitor;Quantitative Trait Loci;Resources;Rodent;Rodent Model;Role;Scheme;screening;Testing;Therapeutic;trait;transcriptome sequencing;Untranslated RNA;validation studies;Variant;Viral Vector;Water;Work

PROJECT_TITLE: Project 1 - Novel gene networks modulating progressive ethanol consumption in DO mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The neurobiological basis of socioemotional symptoms, a debilitating feature of many neurological and psychiatric disorders, is not well understood. The brain and autonomic nervous system cohesively interact to support socioemotional well-being, and cutting-edge analytical techniques can now reveal the rich dynamic properties of these systems. By leveraging behavioral variant frontotemporal dementia, a neurodegenerative disease of socioemotional deficits that targets these systems, the goal of the proposed project is to determine how autonomic and functional brain network dynamics shape human emotions and social behavior in healthy and clinical populations.

PI_NAMEs: PASQUINI, LORENZO  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Affective Symptoms;Aging;aging population;Algorithms;Applications Grants;Area;Arousal;Autonomic nervous system;Award;Behavioral;behavioral variant frontotemporal dementia;Biometry;Brain;Brain region;Breathing;California;career;Clinical;comparison control;Computing Methodologies;Data;data acquisition;Dementia;Deterioration;Diagnostic;Disease;dynamic system;Educational Status;Elderly;Emotional;emotional functioning;emotional symptom;Emotions;Empathy;Exhibits;fundamental research;Future;Galvanic Skin Response;geriatric neuropsychiatry;Goals;Health;healthy aging;Human;Image;Impairment;improved;innovation;Lesion;Link;Machine Learning;machine learning algorithm;Magnetic Resonance Imaging;Maps;Memory;Mental disorders;Mentors;Mentorship;Modeling;Mood Disorders;Moods;multimodal data;multimodality;Nerve Degeneration;Nervous System Disorder;network dysfunction;neural;neural correlate;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;neuroimaging;Neurologist;neuromechanism;Neurons;Neurosciences;older adult;Pathway interactions;Patients;Phase;Physiological;Physiology;Pilot Projects;Play;Population;Postdoctoral Fellow;Productivity;programs;Property;Psychiatry;Psychologist;recruit;Regulation;Research;Research Personnel;Rest;Role;Running;Sampling;San Francisco;Scanning;Series;Severities;Shapes;skills;Social Behavior;Syndrome;System;Techniques;Time;Training;Universities;Virginia;Well in self;Work

PROJECT_TITLE: Dynamic neural systems underlying socioemotional function


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Genetics;Substance Misuse

PI_NAMEs: GROTEWIEL, MICHAEL S. (contact)

PROJECT_TERMS: Alcohol abuse;alcohol abuse therapy;alcohol behavior;alcohol effect;alcohol research;alcohol response;alcohol use disorder;behavioral response;Bioinformatics;Caenorhabditis elegans;Candidate Disease Gene;Data;Development;Diagnosis;Drosophila genus;drug disposition;Ensure;Ethanol;Etiology;Family;Family member;fly;gene conservation;Gene Family;gene network;Gene Targeting;Genes;Genetic;genetic analysis;genetic information;genome wide association study;Grant;Health;Human;improved;Individual;insight;Investigation;Investments;knock-down;Laboratories;Laboratory Finding;loss of function mutation;Mediator;member;Modeling;Molecular Genetics;Mus;Neurons;novel;novel therapeutic intervention;Orthologous Gene;Pathway interactions;Pilot Projects;Publishing;Rattus;Resistance;response;Risk;RNA Interference;Role;Ryanodine Receptor Calcium Release Channel;Sedation procedure;Societies;Source;success;Testing;transcription factor;transcriptomics;Transgenes

PROJECT_TITLE: Project 2 - Genetic analysis of ethanol-related behavior in Drosophila


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Natural Products;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This project will test the novel hypothesis that increasing parasympathetic activity will result in the improvement of endothelial dysfunction, vascular inflammation and oxidative stress in African Americans.

PI_NAMEs: KIRABO, ANNET ;SHIBAO, CYNDYA ADRIANA (contact)

PROJECT_TERMS: 3-nitrotyrosine;Acetylcholine;Acetylcholinesterase Inhibitors;adduct;African American population;African American Women;Antigen-Presenting Cells;Arteries;Atherosclerosis;Blinded;Blood Vessels;brachial artery;Cardiovascular Diseases;cardiovascular disorder risk;Cells;cholinergic;Clinical;contrast enhanced;cytokine;Data;Development;Diameter;Dose;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experience;F2-Isoprostanes;Fatty acid glycerol esters;Functional disorder;Galantamine;Goals;Harvest;high risk;Hispanic Populations;immune activation;immunogenic;Impairment;improved;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Infusion procedures;Intercellular adhesion molecule 1;Ischemia;Lipids;Measures;Mediating;monocyte;Mononuclear;Morbidity - disease rate;mortality;Mus;NADP;NADPH Oxidase;Nerve;Nitric Oxide;Nitric Oxide Signaling Pathway;novel;Obesity;oxidation;Oxidative Stress;Parasympathetic Nervous System;Participant;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Placebos;Population;Production;Proteins;randomized placebo controlled study;Reactive Oxygen Species;response;Signal Pathway;Skeletal Muscle;Source;Study Subject;Superoxides;Testing;transmission process;Ultrasonography;vascular bed;vascular endothelial dysfunction;vascular inflammation;Vasodilator Agents;Work

PROJECT_TITLE: Enhancing parasympathetic activity to reduce vascular oxidative stress and endothelial dysfunction

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Complementary and Integrative Health;Dietary Supplements;Genetics;Nutrition;Prevention;Substance Misuse

PI_NAMEs: BETTINGER, JILL C (contact)

PROJECT_TERMS: Acids;Acute;Adolescent;adolescent alcohol exposure;Adult;Affect;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol effect;alcohol response;alcohol use disorder;Alcohols;American;Animals;Behavior;behavior test;Behavioral;behavioral phenotyping;behavioral response;Biochemistry;Biological;Biological Process;Brain;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Characteristics;Collaborations;Complex;Defect;design;Development;dietary;Dietary intake;disorder risk;Eicosapentaenoic Acid;Environment;Environmental Risk Factor;Ethanol;Exposure to;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Fish Oils;Future;Gene Expression;gene network;Genes;Genetic;genetic testing;Genetic Transcription;Genotype;Human;insight;Investigation;Learning;lipid mediator;lipid metabolism;lipidomics;Lipids;Liver;Mammals;Measures;Mediating;Messenger RNA;model organism;Modeling;Molecular;Mus;Nature;Nervous System;neural;Neurons;novel;Omega-3 Fatty Acids;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiological;preference;prenatal;Proteins;psychologic;Research Personnel;response;Risk;Risk Factors;risk prediction;Rodent;Role;sedative;Signal Transduction;Source;Supplementation;Testing;Time;translational study;Work

PROJECT_TITLE: Project 3 - Molecular mechanisms of acute ethanol behaviors in C. elegans


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH The biomedical research landscape is changing rapidly, becoming increasingly cross-disciplinary and team- oriented, and broadening its presence beyond the academy. The goal of the proposed renewal is to expand and distribute our successful profession development program, The Whole Scientist, to reach a broader audience. By delivering the program’s benefits to trainees more broadly, we anticipate a diverse scientific workforce that is prepared for the demands of the modern biomedical research landscape. This, in turn, will further strengthen productivity and innovation in both the public and private science and technology sectors and ensure the US remains a leader in biomedical discovery for the benefit of human health.

PI_NAMEs: WRAY, CHARLES G (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Academia;Academy;Address;Adoption;Advisory Committees;Advocacy;Aptitude;Award;Biomedical Research;career;career preparation;Collaborations;Communication;Creativeness;curriculum development;Decision Making;Doctor of Philosophy;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Ensure;Environment;Ethics;experience;Faculty Workshop;Feedback;Feeling;Fostering;Future;Geography;Goals;Government;graduate student;Grant;Health;Human;implementation facilitation;improved;Industry;innovation;Institution;interest;Lead;Leadership;Learning;Maine;member;Mentors;Modernization;novel;Outcome;Participant;peer networks;Persons;Postdoctoral Fellow;Privatization;Productivity;Professional Practice;Program Development;programs;Public Health;remote location;Research;Science;Scientist;self-directed learning;skill acquisition;skills;skills training;Societies;stem;Structure;success;Technology;The Jackson Laboratory;Trainers Training;Training;Training Programs;Translating;Translations

PROJECT_TITLE: The Whole Scientist Program


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: DICK, DANIELLE M (contact)

PROJECT_TERMS: addiction;Adolescence;Affect;Alcohol abuse;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol related problem;alcohol research;alcohol use disorder;Alcohols;Animal Model;Area;Behavior;Behavioral;behavioral phenotyping;biobank;Bioinformatics;Biological;clinical diagnosis;Complex;Consumption;Data;Data Set;Detection;Development;Diagnosis;emerging adulthood;Environment;Environmental Risk Factor;Epidemiology;Ethnic Origin;Foundations;gene discovery;gene network;Genes;Genetic;genetic architecture;genetic association;Genetic Risk;Genetic Techniques;genetic variant;genome wide association study;genome-wide;Genomics;Goals;Health;high risk;Human;human data;improved;Individual;Intervention;Investigation;longitudinal dataset;Maps;Mediating;Mental disorders;Meta-Analysis;Methods;model organism;Multivariate Analysis;Nature;novel;Outcome;Pathway interactions;personalized medicine;Phenotype;polygenic risk score;population based;Prevention;Process;Psychiatry;Race;Risk;Rodent;Running;Sample Size;Sampling;sex;Signal Transduction;social;Structural Models;Structure;Techniques;Testing;trait;Translating;Twin Multiple Birth;Variant

PROJECT_TITLE: Project 4 - Human studies to identify genes and characterize risk pathways involved in alcohol related outcomes


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Doxorubicin (Dox) is among the most effective and widely used drugs for treatment of human cancers. Unfortunately, Dox induces life-threatening cardiotoxicity including cardiomyopathy and heart failure. Our studies aim to understand the key factors that cause this problem and understanding these processes will allow development of new drugs to treat the problem in the future.

PI_NAMEs: SUN, JIANXIN  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adult;Anthracycline;anti-cancer;anticancer activity;Antineoplastic Agents;Apoptosis;Attenuated;Behavior;Binding Proteins;Biology;cancer cell;Cancer Model;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;cardioprotection;Cardiotonic Agents;Cardiotoxicity;Cardiovascular system;chemotherapy;clinically relevant;Complex;Data;Development;Disease;DNA Damage;DNA Topoisomerases;Doxorubicin;Drug toxicity;Drug usage;effective therapy;Event;Exhibits;Family member;Fibrosis;Future;Genomic DNA;Heart;Heart failure;heart function;Heart Injuries;Homeostasis;Human;In Vitro;in vivo;Inflammation;Injury;Knockout Mice;Knowledge;Laboratories;Life;loss of function;Malignant Neoplasms;Mediating;Mediator;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Myocardial dysfunction;novel;novel therapeutics;Nuclear Receptors;overexpression;Pathogenesis;Pathologic;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Pre-Clinical Model;preservation;prevent;Prevention;Process;receptor;Role;Testing;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;Topoisomerase;Toxic effect;TP53 gene;Transgenic Organisms;translational potential;tumor;Work

PROJECT_TITLE: Prevention of anthracycline-induced cardiotoxicity by Nur77 activation

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Human Genome;Pediatric;Prevention;Substance Misuse;Underage Drinking

PI_NAMEs: WEBB, BRADLEY TODD (contact)

PROJECT_TERMS: addiction;Address;Age;Alcohol abuse;alcohol behavior;Alcohol consumption;alcohol use disorder;Alcohols;Alleles;Architecture;base;biobank;Catalogs;Child;cigarette smoking;Classification;Code;Communities;comorbidity;Complex;Data;Data Set;Detection;Disease;disorder risk;Elements;Epidemiology;Etiology;exome;exome sequencing;Family;family genetics;First Births;functional genomics;Gene Frequency;gene network;Generations;Genes;Genetic;genetic analysis;genetic architecture;Genetic study;Genome;genome sequencing;genome wide association study;genome-wide;Genotype;Goals;Human;improved;indexing;Individual;Intervention;Investigation;Large-Scale Sequencing;Measures;Medical;Mendelian randomization;Mental Health;Methods;model building;Modeling;Molecular;Molecular Genetics;next generation sequencing;novel;Nucleotides;Outcome;Pattern;Phenotype;phenotypic data;physical conditioning;pleiotropism;Population;population based;Prevention;Proteins;rare variant;Risk;Risk Factors;risk variant;Sample Size;Sampling;Source;Specificity;success;Testing;Time;trait;Twin Multiple Birth;Untranslated Regions;Variant;Weight

PROJECT_TITLE: Project 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studies


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Discoid lupus erythematosus is a chronic autoimmune skin disease characterized by a complex immune infiltration and current treatments are often ineffective. We will perform translational immunologic research including spatial proteomics and spatial transcriptomics to delineate the key cells and inflammatory pathways that drive disease development in both humans and mice, with particular emphasis on immune inhibitory receptors. This wok will advance our understanding of discoid lupus and help identify additional targeted strategies for treating this disease.

PI_NAMEs: VESELY, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Affect;Agonist;Antibody Activation;Antigen-Antibody Complex;Architecture;Autoimmune;Binding;career development;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;Cell Separation;cell type;Cells;cellular imaging;Chronic;chronic inflammatory skin;Cicatrix;clinical development;cytokine;cytotoxic CD8 T cells;Data;Dendritic Cells;Dermatologist;Development;Development Plans;digital;Discoid Lupus Erythematosus;Disease;Disproportionately impacts women;Doctor of Philosophy;Epidermis;FDA approved;Flow Cytometry;Future;Gene Expression;Gene Expression Profile;Generations;Goals;Hair;Human;Imaging technology;Immune;immune activation;immune cell infiltrate;Immunofluorescence Immunologic;Immunologics;Immunologist;Impairment;improved;In Situ;Infiltration;Inflammatory;Interferon Type I;Interferons;keratinocyte;Knockout Mice;Knowledge;Label;Lead;Lesion;Lichen Planus;Ligands;Lupus;lupus cutaneous;Maps;Mediator;medical schools;mentoring community;Mentors;Modeling;Molecular;Monitor;mouse model;Multiplexed Ion Beam Imaging;Mus;Myeloid Cells;new therapeutic target;novel;novel therapeutics;Pain;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Persons;Phenotype;Play;Principal Investigator;Production;Proteins;Proteomics;Pruritus;Psoriasis;Quality of life;receptor;Receptor Activation;Receptor Signaling;Research;Resolution;Role;Signal Transduction;skill acquisition;Skin;skin biopsy;skin disorder;Skin Tissue;Suppressor-Effector T-Lymphocytes;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;targeted treatment;therapeutic target;transcriptome sequencing;transcriptomics;Visualization;Wild Type Mouse;women of color;Work

PROJECT_TITLE: Role of VISTA in discoid lupus erythematosus

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative We propose a three-year bioengineering undergraduate research training program that will expose a diverse population of students from underrepresented backgrounds to existing research opportunities, facilitate multiple positive interactions with participating faculty, as well as build the trainee’s cultural capital and sense of community through our six-semester one-credit required course and three-year research experience in the laboratories of our faculty mentors. Our goal is to use evidence-based best practices to prepare our trainees for a career in biomedical research.

PI_NAMEs: ARRIA, AMELIA M;MAISEL, KATHARINA  (contact);MORSS CLYNE, ALISA S;STROKA, KIMBERLY

PROJECT_TERMS: Active Learning;African-American Graduate Student;Awareness;Biomedical Engineering;Biomedical Research;Black American;career;career development;Career Mobility;CCL7 gene;college;Color;Communication;Communities;Degree program;Doctor of Medicine;Doctor of Philosophy;Educational process of instructing;Educational workshop;Ensure;Environment;experience;Face;Faculty;faculty mentor;falls;Fellowship;financial literacy;graduate school;improved;Internships;Investments;Learning;lectures;Literacy Programs;Maryland;Mentors;Methods;peer coaching;Peer Review;Population;pressure;programs;Research;research faculty;Research Personnel;Research Training;Rotation;Science;Students;Training;Training Programs;undergraduate research;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: MARC at University of Maryland, College Park

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Cardiovascular;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE In this proposal, we will investigate the determinants of venous endotheliopathy and thrombosis in COVID19 patients. We will accomplish this objective by deploying a novel Vein-Chip technology that comprises of the human vascular cells within a native composition and geometry of a typical human vein and exposed to physiological hemodynamic forces that could regulate the responses to the SARS-CoV-2 viral infection. The Vein-Chip is expected play a critical role in our development and optimization of life-saving therapies for COVID19 patients.

PI_NAMEs: CONNOR, JOHN H (contact);COOKE, JOHN P;JAIN, ABHISHEK

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Adhesions;American;Anticoagulants;Anticoagulation;Apoptosis;Attention;Attenuated;Automobile Driving;Autopsy;Biological Assay;Biomedical Engineering;Blood;Blood coagulation;Blood Vessels;Cells;Cessation of life;China;clinical phenotype;Clinical Research;combinatorial;Complex;Computational Biology;COVID-19;COVID-19 patient;COVID-19 treatment;cytokine;Data;Deep Vein Thrombosis;design;Development;Devices;differential expression;Disease;Distal;efficacy evaluation;Endothelial Cells;endothelial dysfunction;Endothelium;Enzyme Inhibitor Drugs;Exposure to;Geometry;hemodynamics;Homeostasis;Human;Immune response;improved;Infection;Inflammation;Inflammatory;innovation;Interdisciplinary Study;Kidney;Lead;Life;Lower Extremity;Lung;mechanotransduction;Mesentery;Modeling;Molecular Biology;mortality;NF-kappa B;novel;novel coronavirus;Organ;organ on a chip;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Physiological;Play;Pre-Clinical Model;Predisposition;prevent;Proteins;Proteomics;receptor;recruit;Research;Respiratory Failure;response;Role;SARS-CoV-2 infection;severe COVID-19;Signal Pathway;Stroke;Structure;Surgeon;targeted treatment;Techniques;Technology;Therapeutic;Therapeutic Clinical Trial;thromboinflammation;Thrombosis;transcriptome;transcriptome sequencing;Veins;Venous;venous thromboembolism;Venous Thrombosis;Viral;Virus;Virus Diseases

PROJECT_TITLE: Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered vein-chip

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Black people experience among the highest rates of negative alcohol-related consequences and severity of disordered use compared to other racial/ethnic groups, highlighting the need for effective alcohol treatment for Black drinkers. The objective of this proposal is to identify the impact of stressors related to the Black experience, most notably, race-related stress, on alcohol craving among Black people to inform culturally tailoring treatment for this group. Acknowledging race-related stressors and other factors unique to the Black experience in alcohol treatment may help Black people with AUD to feel understood by their clinicians thus enhancing treatment satisfaction, retention, and outcomes.

PI_NAMEs: HAENY, ANGELA MARIA (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: acceptability and feasibility;Address;Adult;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol misuse;alcohol relapse;alcohol related consequences;alcohol use disorder;Area;Black Populations;Black race;career;Clinical;Clinical Research;Clinical Trials;Cognitive Therapy;Collaborations;Communities;community based participatory research;coping;coping mechanism;Coping Skills;craving;Cues;Data;Data Collection;Development;Discrimination;Disease;drinking;Dropout;Ethnic Population;Event;experience;follow-up;Future;Goals;health disparity;Imagery;improved;Individual;individualized medicine;Intervention;Interview;Knowledge;Laboratories;Lead;Learning;Legal;Link;maltreatment;medical schools;Mentorship;minority stress;Modeling;Music;Outcome;Participant;Persons;Pilot Projects;Police;Population;preference;Procedures;Process;Qualifying;Qualitative Methods;Qualitative Research;Race;racial population;racism;Relaxation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Resources;satisfaction;Severities;skills;Stress;Stressful Event;stressor;Syphilis;Taxes;Testing;therapy development;Training;treatment disparity;treatment group;treatment research;Trust;Work

PROJECT_TITLE: Understanding Race-Related Stress as a Mechanism Associated with Alcohol Craving to Inform Culturally-Adapting Alcohol Treatment for Black Adults


ADMINISTERING_IC: TR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dystonia;Natural Products;Neurodegenerative;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Cervical dystonia is a rare but debilitating neurologic disorder that involves abnormal positions and/or movements of the head. Many patients do not get satisfactory benefit from current treatment options, and the conventional methods for evaluating the impact of new treatments have several limitations. This project will evaluate new methods for measuring treatment impact based on computer analyses of video recordings of patients, thereby optimizing the potential for evaluating the outcome of multi-site clinical trials of future treatments.

PI_NAMEs: PETERSON, DAVID A (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Acceleration;analog;Anxiety;botulinum neurotoxin injection;botulinum toxin treatment;Botulinum Toxins;Cephalometry;Cervical Dystonia;Clinical;clinical care;clinical outcome assessment;Clinical Trials;Computer Analysis;Computer Vision Systems;Data Set;Disease;Dose Limiting;Dystonia;Exhibits;Face;Fatigue;Focal Dystonias;Future;Head;Head Movements;Image;impression;improved;Intervention;Measures;Mental Depression;Methods;Motor;motor impairment;motor symptom;Multi-Institutional Clinical Trial;Neck;Nervous System Disorder;non-motor symptom;Oral;Outcome;Pain;participant enrollment;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Positioning Attribute;Posture;Reporting;response;Rotation;Sample Size;Self Assessment;Self Perception;Severities;side effect;software development;System;Technology;Testing;Time;treatment choice;treatment effect;treatment response;Tremor;Validation;Video Recording;Visual

PROJECT_TITLE: Synergistic clinical outcome assessments for cervical dystonia


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Contraception/Reproduction;Dental, Oral, and Craniofacial Disease;Estrogen;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative  A single mutation (C134W) in the forkhead transcription factor FOXL2 is universally associated with adult type granulosa cell tumors, yet the molecular basis underlying the oncogenic effect of FOXL2C134W is unclear. We have mapped putative oncologic dependencies using combined in vitro and bioinformatic methods. Using a novel, inducible, spontaneous genetically-representative model, we will investigate the mechanisms by which FOXL2C134W impacts granulosa cell function and tumorigenesis. !

PI_NAMEs: SHIMASAKI, SHUNICHI  (contact);STUPACK, DWAYNE G.

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: 3-Dimensional;Activins;Adult;advanced disease;Aging;Aromatase;Aromatase Inhibitors;autocrine;Bioinformatics;Biology;blepharophimosis-ptosis-epicanthus inversus syndrome;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;chemotherapy;clinical development;clinical diagnosis;Collaborations;craniofacial;Craniofacial Abnormalities;craniofacial development;Dependence;Detection;Development;Diagnosis;Disease;Doxycycline;Endocrine;Endometrial;Environment;Enzymes;Estrogen Receptors;Estrogens;Ethnic Origin;Etiology;Family;Female;female reproductive tract;folliculogenesis;forkhead protein;Fostering;FOXO1A gene;Funding;Gene Expression;Genes;Genetic;Genetic Transcription;Geographic Locations;Goals;gonad development;Grant;granulosa cell;granulosa cell tumor;Homeostasis;Hormonal;Human;In Situ;In Vitro;in vivo;inducible gene expression;Infertility;inhibitor;innovation;insight;Intervention;Left;Life;Ligands;MADH3 gene;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;member;Methods;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel;Oncogenic;Oncologist;Oocytes;Operative Surgical Procedures;Organoids;Outcome;Ovarian;ovarian dysfunction;Ovarian Follicle;Ovarian Granulosa Cell;Ovary;Ovulation;paracrine;Patients;Pelvis;Pharmaceutical Preparations;pharmacologic;Physiological;Postmenopause;preclinical development;prevent;prognostic;Radiation;Recommendation;Recurrence;Recurrent disease;Research Personnel;Role;Serum;sex;Signal Transduction;Somatic Mutation;standard of care;System;Telomerase;Testing;theca cell;Time;Tissues;Transcript;transcription factor;transcriptome;Transgenic Mice;Transplantation;tumor;Tumor Debulking;tumorigenesis;Woman;women's treatment

PROJECT_TITLE: FOXL2 in Adult Granulosa Cell Tumorigenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE The proposed research is relevant to public health because it is expected to increase understanding of the pathogenesis of retinitis pigmentosa, the most common inherited retinal dystrophy, while testing a potential metabolic reprogramming therapy in a mouse model. Thus, the proposed research is relevant to the part of the NEI’s mission that pertains to supporting vision research to protect and prolong vision.

PI_NAMEs: HURLEY, JAMES BRYANT;TSANG, STEPHEN H (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Adult;aerobic glycolysis;Affect;Age;Anemia;antagonist;autosome;Blindness;Blood capillaries;Carbon;Cells;Cessation of life;Choroid;Citric Acid Cycle;Clinical;Clinical Trials;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Cone;cost;Coupling;CRISPR therapeutics;Data;Dependovirus;Disease;Drug Kinetics;efficacy evaluation;Enzyme Inhibition;European;experimental study;Functional disorder;Funding;Future;Gene Mutation;gene therapy;Genes;Genetic;Glucose;Glycolysis;Goals;hemangioblastoma;Human;Inherited;innovation;Interphase Cell;Investigational Drugs;Investigational New Drug Application;Knock-out;Knowledge;Lead;Mediating;Medicine;Metabolic;Metabolic Pathway;Metabolism;metabolome;Mission;Modeling;Modification;mouse model;Mus;Mutation;Neurodegenerative Disorders;normoxia;novel;novel therapeutics;Oral Administration;Organoids;Outcome;Pathogenesis;Patients;pharmacologic;Phase;photoreceptor degeneration;Photoreceptors;preservation;Process;Procollagen-Proline Dioxygenase;Production;promoter;Proteins;Public Health;repaired;Research;response;Retina;Retinal Cone;Retinal Diseases;Retinal Dystrophy;retinal rods;Retinitis Pigmentosa;Rod;Role;RPE65 protein;Safety;Shapes;Source;Starvation;Structure of retinal pigment epithelium;Subgroup;Teenagers;Testing;Therapeutic;therapeutic genome editing;therapeutic target;therapeutically effective;Tissues;tool;Toxic effect;Translating;Treatment Cost;Ubiquitination;vector;Vertebrate Photoreceptors;VHL protein;Vision;Vision research

PROJECT_TITLE: Enhancing cone survival in retinitis pigmentosa through cell-specific therapeutic CRISPR editing of a roxadustat target

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Hepatic steatosis is highly associated with obesity, diabetes and atherosclerosis, and has few available pharmacologic interventions. The liver is a major contributor to whole body metabolic homeostasis and a validated target for metabolic drugs, as shown from the great efficacy of statins. In my proposal, I will elucidate the role of the novel protein BASIC in liver physiology, thus advancing our understanding of fundamental mechanisms controlling hepatic lipid droplet morphology which will lead to opportunities for therapeutic intervention in metabolic disease.

PI_NAMEs: UCHIYAMA, LAUREN F (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;adrenergic stress;Adult;Affect;Albumins;Atherosclerosis;Binding;Biochemical;Biological Assay;Biology;blood glucose regulation;Body Composition;Brown Fat;C-terminal;Cardiovascular Diseases;Cells;Chimeric Proteins;Cholesterol;Cirrhosis;Data;Diabetes Mellitus;Dyslipidemias;effective therapy;Endoplasmic Reticulum;energy balance;Energy Metabolism;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;gain of function;Gene Expression;Gene Expression Profiling;Genes;Genus Hippocampus;Glucose;Goals;Hepatic;Hepatocyte;High Fat Diet;high risk;Histology;Homeostasis;Hypertriglyceridemia;Immunoprecipitation;Impairment;In Vitro;in vivo;Indirect Calorimetry;inhibitor;insight;Insulin Resistance;Intervention;Ketones;Knock-out;Laboratories;Life Style Modification;lipid biosynthesis;lipid metabolism;Lipids;Lipolysis;Lipoproteins;Liver;liver development;Liver diseases;Liver Failure;Liver Fibrosis;liver transplantation;loss of function;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;Morphology;mouse model;Mus;N-terminal;Names;non-alcoholic fatty liver;non-alcoholic fatty liver disease;novel;Obesity;Organelles;overexpression;oxidation;Pathologic;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Physiology;Plasma;Population;prevent;Primary carcinoma of the liver cells;Production;protein expression;Proteins;Proteomics;Regulation;Research;Respiration;response;Role;Spirometry;superresolution microscopy;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Thermogenesis;Tissues;transcriptome sequencing;Triglycerides;United States;vector;Very low density lipoprotein;very low density lipoprotein triglyceride;western diet

PROJECT_TITLE: Regulation of hepatic lipid metabolism by novel protein BASIC


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Natural Products

ORG_CITY: Auburn

ORG_DEPT: CHEMISTRY

ORG_NAME: AUBURN UNIVERSITY AT AUBURN

ORG_STATE: AL

PHR: Project Narrative This proposal will investigate catalytic, stereoselective dearomatization reactions of heteroarenes to synthesize non-aromatic heterocycles. These non-aromatic heterocycles are among the most common structural motifs in active pharmaceutical ingredients. Thus, enabling their efficient synthesis will allow rapid and cost-effective access to pharmaceuticals that greatly benefit the society.

PI_NAMEs: KARIMOV, RASHAD  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Synthesis of Partially Saturated Nitrogen Heterocycles Through Stereo- And Regioselective Dearomatization of Heteroarenes


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Controversy exists over the risk to benefit ratio of medical marijuana for adults with chronic non-cancer pain (CNCP) on chronic opioid therapy (COT). The primary goal of this proposal is to assess whether medical marijuana, when added to a behavioral prescription opioid taper support program, improves pain and reduces opioid dose in adults on COT for CNCP more so than the behavioral intervention alone. This information is critical to better inform patients and clinicians about the extent to which medical marijuana use may be beneficial or harmful to this patient population.

PI_NAMEs: EVINS, A EDEN;GILMAN, JODI  (contact)

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Address;Adjuvant Therapy;Adult;Agreement;Anxiety;anxiety symptoms;Attention;Behavior Therapy;Behavioral;Benefits and Risks;Cannabis;Chronic;chronic pain;chronic pain management;cognitive function;cognitive performance;Complex;Data;Death Rate;depressive symptoms;Development;diaries;Dose;Effectiveness;Enrollment;executive function;functional status;Goals;Health Personnel;improved;interest;Intervention;Legal;Manuals;marijuana use;Medical;Medical Marijuana;Memory;Mental Depression;Neuropathy;non-cancer chronic pain;Numeric Rating Scale;Opioid;opioid mortality;opioid overdose;Opioid Rotation;opioid tapering;opioid therapy;opioid use;opioid use disorder;Outcome;Pain;Pain interference;pain patient;painful neuropathy;Participant;patient population;Patients;Performance;Pharmaceutical Preparations;Policy Maker;Population;pragmatic trial;prescription opioid;primary outcome;programs;Provider;Public Health;Quality of life;Randomized;Reporting;Risk;secondary outcome;Severities;Short-Term Memory;Site;Support Groups;Symptoms;Testing;Time;trend;United States;Urine;virtual;Visit;Waiting Lists

PROJECT_TITLE: Medical Marijuana, Pain, and Opioid Use in Patients with Chronic Non-cancer Pain

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Digestive Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: Project Narrative Evidence suggests that Alzheimer’s disease (AD), the most common cause of dementia, also affects the gut. The proposed research will identify critical pathophysiological pathways that affect the gut and precede cognitive decline. The study will identify targets in the microbiota and gut immune cells that will inform novel prevention and intervention strategies for AD and aging-associated dementia.

PI_NAMEs: BECKER, LAREN  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: abeta accumulation;Accounting;Affect;Age;age group;Age Months;age related changes;Aging;aging related;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Animal Disease Models;Antibiotics;Apoptosis;APP-PS1;Biology of Aging;Brain;brain tissue;Cells;Characteristics;Chronic;Cognition;cognitive change;cognitive function;Colon;Constipation;cytokine;Data;Dementia;Deposition;Development;Disease;Disease associated microglia;Disease Progression;Elderly;Enteral;Enteric Nervous System;Euthanasia;experimental study;Fecal Incontinence;fecal transplantation;Feces;Functional disorder;gain of function;Gastric Emptying;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Motility;Gastrointestinal tract structure;genetic signature;gut microbiota;gut-brain axis;Homeostasis;host microbiota;Human;IL18 gene;Immune;immune cell infiltrate;Impaired cognition;Impairment;Individual;Inflammasome;Inflammation;Inflammatory;Interleukin-6;Intervention;ITGAX gene;Lead;Literature;loss of function;Macrophage;Maps;Measures;Metagenomics;microbial;microbiota;Microglia;Motility;motility disorder;mouse model;multidisciplinary;Mus;Neurodegenerative Disorders;Neuroimmune;Neuroimmune system;neuroinflammation;neuron loss;Neurons;novel;old mice;Pathogenesis;Pathway interactions;Peripheral Nervous System;Phenotype;Plasma;Play;Population;Prevention;Prevention strategy;Probability;probiotic supplementation;Process;PTPRC gene;Reporting;Research;Research Personnel;Role;Science;Senile Plaques;Signal Transduction;Small Intestines;spatiotemporal;Testing;therapeutic target;Time;Tissues;Transgenic Mice;transmission process;United States;Wild Type Mouse

PROJECT_TITLE: Altered ENS Neuroimmune Interactions Disrupt Gastrointestinal Motility in Alzheimers Disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ED_INST_TYPE: SCHOOLS OF EDUCATION

ORG_CITY: EL PASO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: PROJECT NARRATIVE The UTEP FIRST program will operationalize strategic Diversity, Equity and Inclusion [DEI] initiatives that will provide an integrative and cohesive theme for addressing the defined FIRST program goals of: (1) fostering sustainable institutional culture change; (2) promoting institutional inclusive excellence by hiring a diverse cohort of new faculty; and (3) supporting faculty development, mentoring, sponsorship, and promotion. A novel, interdisciplinary, and multi-factorial mentoring model will support minority and underrepresented faculty hired and mentored in a cohort and cluster model. This program will provide a framework for investigators to significantly impact Hispanic health disparities by driving institutional excellence in inclusiveness, diverse and underrepresented faculty development, and cutting-edge research in Hispanic health disparities.

PI_NAMEs: CORRAL, GUADALUPE ;KENNEY, MICHAEL J;MANGADU, THENRAL ;ODELL, LAURA ELENA;PENNINGTON, DEANA ;WIEBE, JOHN S. (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Academic support;Achievement;Address;Automobile Driving;Biomedical Research;Classification;cohort;Communities;community building;Community of Practice;Creativeness;Development;Discipline;diversity and inclusion;Documentation;early-career faculty;Education;education research;Environment;Equity;equity, diversity, and inclusion;Ethnic Origin;Evaluation;Evidence based practice;Faculty;faculty support;Fostering;Foundations;Funding;Goals;Health Disparities Research;health disparity;health inequalities;Hispanic;Hispanic Populations;Hispanic-serving Institution;improved;Infrastructure;innovation;Institution;Institutionalization;Interdisciplinary Study;interest;intersectionality;Investments;Knowledge;Mediating;Mentors;Mexican Americans;Mexico;Minority;minority health disparity;minority investigator;Modeling;novel;Organizational Culture;Outcome;Persons;Policies;Positioning Attribute;Procedures;Process;Productivity;programs;recruit;Reduce health disparities;Research;Research Activity;research faculty;Research Personnel;Resources;Science;Scientist;social;success;Teacher Professional Development;Testing;Texas;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Vision;Work;Workload

PROJECT_TITLE: UTEP FIRST: United Toward Equity and Progress: Faculty Institutional Recruitment for Sustainable Transformation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PENNINGTON, DEANA  (contact)

PROJECT_TERMS: Achievement;Administrator;Adopted;Adoption;American Association for the Advancement of Science;Behavior;Biomedical Research;cohort;college;Cultural Backgrounds;data dashboard;Decision Making;Development;development policy;Education;Educational workshop;empowerment;Endowment;Ensure;Environment;Equity;Evaluation;Faculty;faculty support;Feedback;Future;Goals;Grant;Growth;Health Disparities Research;health disparity;health record;Hispanic;Hispanic Populations;improved;Individual;Infrastructure;Institution;Institutional Policy;Institutionalization;Investments;Knowledge;Leadership;Learning;Mentors;Minority Groups;Modeling;Organizational Culture;organizational structure;Outcome;Performance;Policies;Principal Investigator;Problem Solving;Procedures;Process;programs;Qualifying;recruit;Reduce health disparities;Research;Research Personnel;Resources;Role;Schools;science, technology, engineering, mathematics, and medicine;Self Assessment;Seminal;skills;Social Development;Structure;Students;success;Teacher Professional Development;Universities;Work

PROJECT_TITLE: UTEP FIRST Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-W]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Retinoblastoma (Rb) is a developmental tumor of the retina and a significant contributor to childhood cancer death worldwide. For many patients, the only life-saving treatment option is removal of the affected eye. A major obstacle to the development of targeted therapies that spare the normal tissues in the eye is the lack of laboratory models in which these tumors can be studied. Emerging 3-Dimensional organoid culture techniques, tissue engineering applications, gene editing, and single-cell resolution genetic analysis have the potential to create platforms in which Rb tumor pathobiology can be fully elucidated. We have developed a 3D Retinal Organoid platform which incorporates all of these new technologies and is capable of recapitulating the biological nuances of human retinoblastoma.

PI_NAMEs: HARBOUR, JAMES WILLIAM;PELAEZ, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Animals;Bar Codes;Biocompatible Materials;bioinformatics pipeline;Biological;Biological Models;Biomimetics;Bioreactors;cancer genomics;Cell Proliferation;cell type;Cells;Child;childhood cancer mortality;Clinical Management;clinical phenotype;Clone Cells;Compensation;cost;CRISPR/Cas technology;Culture Techniques;Data;Defect;Dependence;design;Developed Countries;Developing Countries;Development;differentiation protocol;Disease;DNA sequencing;drug development;Drug Targeting;druggable target;Embryo;Engineering;Environment;Equilibrium;estrogen-related receptor;Event;Excision;Eye;gene editing technology;Genes;Genetic;genetic analysis;genetic corepressor;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;genomic aberrations;Health;Human;human disease;human induced pluripotent stem cells;Hypoxia;improved;in silico;in utero;Invaded;Knowledge;Laboratories;Lead;Left;Life;Light;Loss of Heterozygosity;Malignant - descriptor;Malignant Childhood Neoplasm;malignant neoplasm of eye;Malignant Neoplasms;Modeling;Molecular;Molecular Abnormality;mouse model;multidisciplinary;Mus;mutant;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;Neural Retina;Neuronal Hypoxia;new technology;next generation;Normal tissue morphology;Nuclear Orphan Receptor;Optic Nerve;Organ;Organoids;Output;Oxygen;p107 protein;Parents;Pathway interactions;Patients;Pattern;pharmacologic;Phase;Phenotype;Photoreceptors;Physiological;premalignant;preservation;Procedures;Proliferating;psychologic;RB1 gene;Resolution;Retina;Retinal Cone;Retinal Neoplasms;retinal neuron;Retinal Photoreceptors;retinal progenitor cell;Retinoblastoma;retinogenesis;Rod;self assembly;single-cell RNA sequencing;social stigma;stem cell biology;Stimulus;Survival Rate;System;targeted treatment;Testing;Therapeutic;therapeutic candidate;Time;tissue culture;Tissue Engineering;Tissues;TP53 gene;transcriptome sequencing;tumor;tumor progression;Tumor Suppressor Proteins;Undifferentiated;Vision;Visual;Visual impairment

PROJECT_TITLE: 3-Dimensional Retinal Organoid Platform for the Study of Retinoblastoma

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cancer;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Hematopoietic stem cells, which are the source of all blood cells throughout our lifetime, form in the embryo. The goal of this research is to identify important molecules that regulate the formation of hematopoietic stem cells in the embryo. The research may ultimately guide the design of new protocols for generating hematopoietic stem cells from other cell sources for use in transplantation.

PI_NAMEs: SPECK, NANCY  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Arteries;Binding;Biochemistry;Blood Cells;Bone Marrow;Bone Marrow Purging;Cell Differentiation process;Cell Ontogeny;Cell Physiology;Cells;Core-Binding Factor;data analysis pipeline;Data Set;design;Development;Embryo;Embryonic arterial structure;embryonic stem cell;Endothelial Cells;Engraftment;Enhancers;Failure;Funding;Genes;Genetic;Goals;Growth;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell expansion;hematopoietic stem cell formation;Hematopoietic stem cells;Hematopoietic System;hemogenic endothelium;Human;human embryonic stem cell;human induced pluripotent stem cells;human stem cells;induced pluripotent stem cell;Knowledge;Learning;leukemia virus;Measures;Molecular;Mus;Myelogenous;Names;novel;Pathway interactions;Peptide Initiation Factors;Population;Process;progenitor;Protocols documentation;reconstitution;Regenerative Medicine;Repression;Research;Resources;RUNX1 gene;Signal Pathway;Source;Specific qualifier value;stem cell proliferation;stem cells;Testing;tool;transcription factor;Transitional Cell;Transplantation

PROJECT_TITLE: Biochemistry of Leukemia Virus Core-Binding Factor

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Caregiving Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Telehealth;Unintentional Childhood Injury

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Pediatric traumatic injury (PTI) is a public health priority, with nearly 300,000 children experiencing injuries that require hospitalization each year. These children, and their caregivers, are affected in many ways that may affect quality of life, emotional and behavioral health, physical recovery, family roles and routines, and academic functioning; yet, US trauma centers do not adequately address these outcomes and a scalable national model of care for these families is needed. The present research will develop, evaluate, and test CAARE (Caregivers’ Aid to Accelerate Recovery after pediatric Emergencies), an intervention that was informed by, and designed for, caregivers of young children after PTI to address the behavioral and emotional needs of caregivers and children through education, self-monitoring, and coping resources.

PI_NAMEs: RIDINGS, LEIGH E. (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acceleration;Accidental Injury;Address;Adult;Affect;Age;Animals;Area;Award;barrier to care;Behavioral;behavioral health;behavioral outcome;Bite;career;career development;Caregivers;Caring;Child;Child Traumatic Stress;Childhood;Clinical;Clinical Services;Clinical Trials;Clinical Trials Design;Communication;Consultations;coping;cost;cost effective;cost efficient;Critical Illness;Data;Data Analyses;design;Development;Distress;Education;effectiveness/implementation trial;Elements;Emotional;Endowment;Enhancement Technology;Ensure;Environment;Equilibrium;Evaluation;evidence base;experience;falls;Family;follow-up;Functional impairment;Goals;Grant;Health;Health Status;Health Technology;Hospitalization;implementation evaluation;implementation science;Improve Access;Individual;Injury;innovation;International;Intervention;Interview;iterative design;longitudinal analysis;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;mHealth;Modeling;Monitor;National Institute of Child Health and Human Development;Outcome;Patients;pediatric emergency;pediatric trauma;pilot test;Population;post-traumatic stress;Post-Traumatic Stress Disorders;Preparation;Prevention Research;programs;Protocols documentation;public health priorities;Publications;Quality of Care;Quality of life;Race;Reaction;Recommendation;Recovery;Research;resilience;Resources;Risk;Risk Assessment;Risk Reduction;Role;screening;Self Care;Services;Site;skills;societal costs;statistics;Structure;success;Symptoms;Technology;Testing;Time;Training;Trauma;trauma care;trauma centers;Trauma Research;Traumatic injury;treatment research;United States National Institutes of Health;usability;Vehicle crash;Work;Writing

PROJECT_TITLE: A Scalable mHealth Resource to Facilitate Behavioral and Emotional Recovery after Pediatric Traumatic Injury

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CORRAL, GUADALUPE  (contact)

PROJECT_TERMS: Achievement;Address;Administrator;cohort;Collaborations;college;Communication;Communication Programs;Data;design;Development;Disabled Persons;diversity and inclusion;Documentation;Effectiveness;effectiveness testing;Ensure;Environment;Equity;Ethnic Origin;Evaluation;Evidence based practice;Faculty;Faculty Recruitment;faculty support;flexibility;Fostering;Goals;Health Disparities Research;higher education;Hispanic;Immigrant;Impact evaluation;improved;Individual;Infrastructure;innovation;Institution;institutional capacity;Institutional Policy;Institutionalization;intersectionality;intervention program;Leadership;Linguistics;Literature;Measures;Mentors;Mentorship;Methods;Minority;minority health disparity;model design;Modeling;Monitor;Needs Assessment;Outcome;Outcome and Process Assessment;Outcomes Research;Output;Phase;Policies;Process;process evaluation;Program Development;Program Evaluation;programs;Race;recruit;Recruitment Activity;Resources;satisfaction;Sexual and Gender Minorities;Shapes;System;Systems Theory;Teacher Professional Development;Testing;Training;United States National Institutes of Health;Workload

PROJECT_TITLE: UTEP FIRST Evaluation Core


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE – Overview: Obesity and the constellation of associated obesity-induced diseases (diabetes, cardiovascular, hypertension, nonalcoholic fatty liver disease, obesity-associated cancer, dementia, prothrombotic, and proinflammatory states) are leading contributors to death and disability. The overarching goal of the UTSW NORC is to enhance research efforts in nutrition and obesity by facilitating interdisciplinary interactions that will speed the translation of basic scientific discoveries into clinically relevant interventions in humans that improve public health.

PI_NAMEs: HORTON, JAY D. (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;adipocyte biology;Animal Model;Animals;Award;base;Behavioral;Biochemical;Blood;Blood Pressure;Body Temperature;Budgets;Cardiovascular system;Cell Separation;Cells;Cessation of life;Clinical;clinically relevant;Collaborations;Communication;Dementia;Development;Diabetes Mellitus;Digestive System Disorders;Direct Costs;disability;Discipline;Disease;DNA Sequencing Facility;Doctor of Philosophy;Education;Elements;Endocrinology;Energy Metabolism;exome sequencing;Extramural Activities;Faculty;Fatty acid glycerol esters;Funding;Gene Expression;Genetic;Glucose Clamp;Goals;Heart Rate;Homeostasis;Hormones;Human;Hyperinsulinism;Hypertension;Image;imaging modality;improved;in vivo;Individual;Inflammatory;Infrastructure;innovation;Interdisciplinary Study;Intervention;Lipids;Liver;Liver diseases;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;member;Mentors;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;Metabolism;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;non-alcoholic fatty liver disease;novel therapeutic intervention;nutrition;Obesity;Obesity associated cancer;obesity treatment;Organ;Paper;Pathway interactions;Peripheral;Phenotype;post-doctoral training;Prevention strategy;programs;Public Health;Regulation;Research;Research Personnel;Research Project Grants;Risk;Scientist;Series;Services;Signal Transduction;single cell sequencing;Skeletal Muscle;Spectrum Analysis;Speed;Telemetry;Time;Tissues;Training;transcriptome sequencing;Translating;Translations;willingness

PROJECT_TITLE: UT Southwestern NORC


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: KINGSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Early identification of individuals at-risk to develop Alzheimer’s disease (AD) at the earliest pathological stages, prior to the onset of the first clinical symptoms, holds the potential to transform the diagnosis and management of this debilitating neurodegenerative disease, reducing disease burden on millions of patients and caregivers worldwide. The retina can serve as a non-invasive ‘window to the brain’ and can be imaged using standard optometry and ophthalmology techniques, allowing for screening for AD risk at routine eye exams in older adults, and subsequent referral for more extensive AD risk evaluation. This study proposes to investigate and validate AD risk screening biomarkers in the retina against standard brain imaging biomarkers, and then explore the utility of combining retinal with blood biomarkers to generate an AD risk detection algorithm for cost-efficient, wide- spread population-based screening.

PI_NAMEs: ALBER, JESSICA  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Algorithms;Alzheimer disease detection;Alzheimer disease prevention;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Atlases;Biological Assay;Biological Markers;biomarker development;Blood;Brain;Brain imaging;brain magnetic resonance imaging;burden of illness;candidate validation;Caregivers;Cause of Death;Central Nervous System;cerebral amyloidosis;Cerebrospinal Fluid;Cerebrum;Clinical;clinical application;clinical research site;Cognitive;Cohort Studies;cost;cost efficient;critical period;Data;Detection;Development;Diagnosis;Disease;Disease Progression;Early identification;Enrollment;Evaluation;follow-up;functional loss;ganglion cell;General Population;Goals;Human;Image;imaging biomarker;Impaired cognition;Incidence;Inclusion Bodies;Individual;Infrastructure;Inner Plexiform Layer;Investigation;Knowledge;Lasers;Magnetic Resonance Imaging;Measures;minimally invasive;Monitor;Nerve Degeneration;Neurobehavioral Manifestations;Neurodegenerative Disorders;novel;observational cohort study;older adult;ophthalmic examination;Ophthalmology;Ophthalmoscopy;Optical Coherence Tomography;Optometry;Outcome;Participant;Pathologic;Pathology;Patients;Phase;Plasma;point of care;population based;Positron-Emission Tomography;pre-clinical;prevent;Prevention trial;preventive intervention;prospective;Public Health;Reference Standards;Research;Retina;Retinal Diseases;retinal imaging;retinal nerve fiber layer;Risk;Risk Assessment;risk prediction;Scanning;screening;Secondary Prevention;Sensitivity and Specificity;Site;Specialist;specific biomarkers;Standardization;success;Symptoms;targeted biomarker;tau Proteins;Techniques;Testing;Therapeutic;United States;uptake;Validation;Visit;Visual;Visualization;Work

PROJECT_TITLE: Longitudinal validation of retinal biomarkers against cerebral imaging in preclinical Alzheimer's disease


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TERMS: 3-Dimensional;Administrator;Annual Reports;Award;Clinical;Clinical Research;Collaborations;Collection;Communication;comorbidity;Data Storage and Retrieval;Disease;doctoral student;Elements;Ensure;Equity;Fostering;Funding;Human;implementation facilitation;improved;Individual;Interdisciplinary Study;International;meetings;member;Metabolic Diseases;Metabolism;Mission;Molecular;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Obesity;Outcome;Personnel Management;Principal Investigator;programs;Progress Reports;Publications;Reagent;Recommendation;Reporting;Research;Research Personnel;Resource Sharing;Schedule;Science;Secure;Series;Services;symposium;Training;Translational Research;Translations;United States National Institutes of Health;Update;web site

PROJECT_TITLE: Admin Core


PI_NAMEs: SCHERER, PHILIPP E (contact)

PROJECT_TERMS: Animal Model;Animals;Biological Assay;Blood;Blood Chemical Analysis;Body Composition;Calorimetry;Cells;Cholesterol;Collection;Communication;cost effective;cytokine;Data;Disease;Dual-Energy X-Ray Absorptiometry;Enzyme-Linked Immunosorbent Assay;Equipment;extracellular;Food;Genus Hippocampus;Glucose;glucose and insulin clamps;Glucose Clamp;glucose tolerance;Glycolysis;Goals;Guidelines;Hepatocyte;Hormones;Hyperinsulinism;Individual;instrumentation;Insulin Resistance;Laboratories;Lipids;magnetic beads;Magnetic Resonance Imaging;Maps;Measurement;Measures;Metabolic;Metabolism;microCT;Mitochondria;Mus;nutrition;Obesity;Pathogenesis;Phenotype;Physiological;pre-clinical;prevent;Quality Control;Rattus;Reagent;Research;Research Personnel;Respiration;Services;sound;Speed;Standardization;Technical Expertise;Technology;temporal measurement;Testing;Tissues;treadmill;Triglycerides;Urine;Water consumption;Work

PROJECT_TITLE: CORE 1 - Animal Phenotyping Core


PI_NAMEs: MCDONALD, JEFF G (contact)

PROJECT_TERMS: Abbreviations;Bile Acids;Clinical;cohort;Communities;Consultations;Contract Services;Contracts;Data Analyses;data dissemination;Education;Eicosanoids;Ensure;Esters;experience;Experimental Designs;Fatty Acids;Funding;Goals;Grant;Human;innovation;instrument;Knowledge;Laboratories;Lipid Biochemistry;lipidomics;Lipids;liquid chromatography mass spectrometry;Maintenance;Mass Fragmentography;Mass Spectrum Analysis;Measurement;Medical center;Methods;novel;nutrition;Obesity;operation;Phospholipids;Physiology;Pilot Projects;Quality Control;Research;Research Personnel;Research Project Grants;Sampling;Services;Sphingolipids;Steroids;Sterols;Training;Work

PROJECT_TITLE: CORE 2 - Mass Spectrometry Core


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Infectious Diseases;Inflammatory Bowel Disease;Mental Health;Microbiome

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Unabated exposure to psychosocial stress changes the immune system and predisposes individuals to increased risk for bowel disease and infection but the biological factors are not fully defined. This project focuses on understanding how cells that line the intestine (epithelial cells) interact with the resident microbes that are harbored in the gut (the gut microbiota) in response to stress. We hypothesize that changes to epithelial cell physiology sets off a cascade of host-gut microbiota interactions that predispose individuals to increased risk for infectious and immune-mediated colitis.

PI_NAMEs: ALLEN, JACOB MATTHEW (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Ablation;Adhesions;Anaerobic Bacteria;Animals;antimicrobial;Bacteria;bacterial resistance;Bacteroides;Biological Factors;catalase;Catecholamines;Cell Line;Cell Physiology;Cellular Stress;Chronic;Citrobacter rodentium;Colitis;Colon;colon microbiota;Corticotropin-Releasing Hormone;Data;Disease;Disease susceptibility;dysbiosis;enteric pathogen;Enterobacteriaceae;Environment;Enzymes;Epithelial Cells;Epithelium;Etiology;Exhibits;experimental study;Exposure to;Family;Female;Flagellin;Functional disorder;gastrointestinal epithelium;Generations;Genetic Predisposition to Disease;Germ Cells;Germ-Free;Glucocorticoids;glycosylation;Growth;gut microbes;gut microbiota;Gut Mucosa;gut-brain axis;Health;Hormone Receptor;Hormones;host microbiota;host-microbe interactions;Human;Hydrogen Peroxide;hypothalamic-pituitary-adrenal axis;Immune;Immune response;Immune system;Incidence;Individual;Infection;Infectious colitis;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;intestinal epithelium;Intestines;Laboratories;Link;male;Mediating;member;Metagenomics;Microbe;microbial;microbial community;microbiome;microbiome analysis;microbiota;mouse model;Mucins;Mucolytics;mucosal microbiota;Mucous body substance;Mucous Membrane;Mus;NADP;Neuraminidase;novel;Organism;Outcome;Oxidases;pathobiont;pathogen;Pathway interactions;Patients;pharmacologic;Physiology;Polysaccharides;Predisposition;Production;Psychological Stress;Psychosocial Stress;psychosocial stressors;Reactive Oxygen Species;Resistance;response;restraint stress;Risk;Role;Severities;Sialic Acids;Side;Signal Transduction;Signaling Molecule;social defeat;social stress;Stress;stressor;Structure;Surface;Sympathetic Nervous System;T-Lymphocyte;targeted treatment;Testing;Thinness;Up-Regulation;villin;Work

PROJECT_TITLE: Role of epithelial ROS signaling in mediating psychological stress-induced mucosal dysfunction and colitis predisposition

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


PI_NAMEs: BURGESS, SHAWN C (contact)

PROJECT_TERMS: Animal Model;Biochemical Pathway;Body Composition;Carbon;Cell Culture Techniques;Characteristics;cofactor;Consult;Data;Data Analyses;design;Dual-Energy X-Ray Absorptiometry;Experimental Designs;experimental study;human model;human subject;Image;imaging approach;Imaging Device;imaging study;in vivo imaging;innovation;Investigation;Isotope Labeling;Label;Lipids;mathematical model;Measurement;Metabolic;metabolic abnormality assessment;Metabolic dysfunction;metabolic imaging;Metabolic Pathway;Metabolism;metabolomics;mouse model;nutrition;Obesity;Pathway interactions;Pattern;Plasma;Research;Research Personnel;spectroscopic imaging;Spectrum Analysis;stable isotope;Techniques;Tissue Extracts;Tissue imaging;Tissues;Tracer

PROJECT_TITLE: CORE 3 - Quantitative Metabolism and Imaging Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: COHEN, JONATHAN CHARLES (contact)

PROJECT_TERMS: Address;biobank;Biological;Cells;Communities;Core Facility;cost;cost effective;Data;database query;Databases;Dedications;design;DNA Sequencing Facility;Equipment;exome;exome sequencing;experience;experimental study;Familiarity;Funding;Genes;Genetic;genetic association;Genetic Markers;genome sequencing;genome wide association study;Genotype;Goals;graphical user interface;Heart;Human Genetics;Human Resources;Individual;Instruction;Laboratories;Medical center;Mendelian randomization;Metabolic;Metabolic Diseases;Metabolic Pathway;Methods;Molecular;Mutation;next generation sequencing;novel;nutrition;Participant;Pathway interactions;Phenotype;phenotypic data;Procedures;Protocols documentation;public database;Recovery;Research Personnel;Resources;response;Sampling;Scientist;Services;single cell sequencing;success;Suggestion;Technology;Testing;tool;trait;transcriptome sequencing;United States National Institutes of Health;whole genome

PROJECT_TITLE: CORE 4 - Genetics, Single Cell Sequencing and RNA seq Core


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE In the present application, we propose to build on recent accomplishments in which we identified and characterized pressure transducing ion channels in trabecular meshwork cells. We will establish their role in regulation of intraocular pressure using new mouse models of glaucoma and characterize the molecular rules that underlie dysfunctional sensing and regulation of pressure sensing in glaucoma. Results from the project are expected to lead towards novel IOP-lowering strategies that will protecting ocular cells from mechanical stress.

PI_NAMEs: KRIZAJ, DAVID  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Ablation;Affect;aging population;Agonist;antagonist;Anterior;aqueous;Aqueous Humor;aqueous humor flow;Autophagocytosis;Biochemical;Biology;Biomechanics;Biophysics;Blindness;Calcium;Cell Communication;Cells;Cellular Stress;Chronic;conditional knockout;coping;Cues;cytokine;Cytoskeleton;Dependence;Drainage procedure;Environment;Epithelium;experience;Extracellular Matrix;Eye;Eye diseases;Fibrosis;Foundations;functional loss;Gene Expression;Genes;Glaucoma;Goals;Homeostasis;hypertensive;Impairment;Injury;Integrins;interest;Ion Channel;Knockout Mice;knowledge base;Lead;Link;Literature;mechanical properties;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Mediator;Membrane;Membrane Microdomains;Mesenchymal;Metabolism;Modality;Modeling;Molecular;mouse model;Mus;Myofibroblast;normotensive;novel;Ocular Hypertension;Open-Angle Glaucoma;Pathologic;Pathway interactions;Permeability;pharmacologic;Pharmacotherapy;Physiologic Intraocular Pressure;Physiological;Piezo 1 ion channel;potassium channel protein TREK-1;Predisposition;pressure;profibrotic cytokine;protein expression;protein function;Regulation;Resistance;response;rho;Risk Factors;Role;Signal Transduction;Specific qualifier value;Stimulus;Stress;Structure of sinus venosus of sclera;success;Swelling;Testing;Tissues;tool;Trabecular meshwork structure;transdifferentiation;Transducers;Work

PROJECT_TITLE: Molecular mechanisms of mechanotransduction in the aqueous outflow pathway

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: HADLEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative A growing number of diseases—such as cystic fibrosis, Parkinson’s, Alzheimer’s, and Huntington’s— arise because proteins fail to fold to their native, functional states, which may lead to loss of the function of the protein and/or pathological aggregation of the misfolded protein. Cells deploy a protein homeostasis network to maintain the health of their proteomes, and Hsp70 molecular chaperones are central hubs in these networks. The proposed research will reveal the fundamental mechanisms whereby Hsp70s carry out their many functions and how it might be possible to therapeutically target them for disease treatments.

PI_NAMEs: GIERASCH, LILA M (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Affect;Affinity;Alzheimer's Disease;Amino Acid Substitution;Binding;Binding Sites;Biochemical;Biological Assay;C-terminal;Cell Physiology;Cells;Charge;Computer Models;coping mechanism;Cystic Fibrosis;Disease;Dissociation;Docking;Fluorescence;Guanine Nucleotide Exchange Factors;Health;Huntington Disease;Hydrophobicity;Learning;Literature;loss of function;Mass Spectrum Analysis;Mediating;Methods;misfolded protein;Modality;Modeling;Molecular Chaperones;Molecular Conformation;N-terminal;Neurons;Nuclear Magnetic Resonance;Nucleotides;Parkinson Disease;Pathologic;Peptides;polypeptide;Post-Translational Protein Processing;presynaptic;Property;protein folding;protein function;Proteins;Proteome;proteostasis;Quality Control;Research;Role;Synaptic Vesicles;therapeutic target;Thinness;Translating;Work

PROJECT_TITLE: Protein folding in the cell: Challenges and coping mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Q(55)R]


PI_NAMEs: ELMQUIST, JOEL K. (contact)

PROJECT_TERMS: Award;Behavioral;Biological;career development;Collaborations;Communities;comorbidity;Data;disorder risk;Eligibility Determination;energy balance;Energy Metabolism;Ensure;Equity;Evaluation;Faculty;Fostering;Functional disorder;Funding;Funding Agency;Genetic;Goals;Grant;innovation;Intervention;Lead;member;Mentorship;Metabolism;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;novel;novel therapeutics;Nutrient;nutrition;Nutritional;Obesity;Obesity associated disease;Output;outreach;Physiological;programs;Publications;recruit;Research;Research Personnel;Research Support;Resources;Scientist;Techniques;Underrepresented Minority;Woman

PROJECT_TITLE: Pilot and Feasibility Program


PI_NAMEs: ZIGMAN, JEFFREY M (contact)

PROJECT_TERMS: Basic Science;clinical care;Collaborations;Communities;Community Outreach;Core Facility;design;Doctor of Philosophy;Education;Educational workshop;Elements;evidence base;Faculty;Family;Fostering;Funding;Goals;graduate student;Health;Health Professional;healthy lifestyle;improved;Individual;Institution;interest;Journals;Knowledge;Maintenance;Metabolic;Metabolic Diseases;Metabolism;Molecular;nutrition;Obesity;Obesity associated disease;obesity management;outreach;outreach program;Overweight;podcast;Postdoctoral Fellow;Principal Investigator;programs;Research;Research Personnel;Science;Series;social media;Students;symposium;Texas;Training Programs;Translational Research;Weight

PROJECT_TITLE: Enrichment Program


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing a new and alternative strategy to treat idiopathic pulmonary fibrosis by targeting lactate metabolism through the inhibition of lactate transporters. Once the molecular mechanisms mediating the beneficial effects of these drugs have been identi- fied, there is the potential for a significant advance in therapy for patients with the disease. Thus, the proposed research is relevant to the NHLBI mission to enable the translation of basic discoveries into clinical practice for the treatment of heart and lung diseases.

PI_NAMEs: OLDHAM, WILLIAM MICHAEL (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Actins;Alveolar fibrosis;antifibrotic treatment;Attenuated;Bioenergetics;Biosensor;Bleomycin;Carbon;Cell Respiration;Cell Therapy;Cells;clinical practice;conditional knockout;Coupled;D-Amino Acid Dehydrogenase;Data;Deposition;Development;differentiation in vitro;Disease;Effector Cell;Exhibits;Extracellular Matrix;Fibroblasts;fibrogenesis;Fibrosis;Fluorescent Dyes;gain of function;Gases;Gene Expression;Generations;Genes;Genetic Transcription;Glycolysis;Glycolysis Inhibition;Heart Diseases;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vivo;inhibitor;innovation;insight;knockout animal;Knockout Mice;Lactate Transporter;Link;loss of function;Lung;Lung Diseases;Lung fibrogenesis;lung injury;mass spectrometric imaging;Measures;Mediating;Mediator;Membrane Potentials;Metabolic;metabolic profile;Metabolism;Mission;Mitochondria;mitochondrial membrane;Modeling;Modernization;Molecular;Myofibroblast;NADH oxidase;National Heart, Lung, and Blood Institute;novel;Oxidases;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;prevent;Production;programs;Public Health;Pulmonary Fibrosis;Reactive Oxygen Species;Research;Resolution;Respiratory Failure;Role;Severities;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;stable isotope;Testing;therapeutic target;Tissue-Specific Gene Expression;transcription factor;transcriptomic profiling;Transforming Growth Factor beta;Translations;transport inhibitor;Work

PROJECT_TITLE: Role of lactate transporters in pulmonary fibrosis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Eye Disease and Disorders of Vision;Neurosciences;Nutrition

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Public Health Relevance Statement Diabetic retinopathy is a leading cause of visual disability worldwide. Current therapies are costly, short-lived, limited to late stages of disease, and ineffective in a sizable number of patients. This application has the potential to improve public health by adding to our understanding of how diabetes affects retinal metabolism, how such changes contribute to early abnormalities in vision, and how they can be corrected to produce new treatments.

PI_NAMEs: RAJAGOPAL, RITHWICK  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Ablation;Acceleration;Acetyl-CoA Carboxylase;Address;Adenosine Monophosphate;Adult;Affect;Agonist;Agreement;Anabolism;ATF6 gene;Biogenesis;Blindness;Calcium;calcium indicator;Catabolism;Cells;Cellular Stress;Clinical;cost;Data;Development;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Disease;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;experimental study;Fatty-acid synthase;gain of function;genetic manipulation;Glucose;Goals;Health;Homeostasis;Human;Hyperglycemia;Image;improved;inhibitor;Injury;Ion Channel;Link;lipid biosynthesis;lipid metabolism;Lipids;Mammalian Cell;Mass Spectrum Analysis;Medium chain fatty acid;Metabolic;Metabolism;Metformin;Modeling;Modernization;Modification;Molecular;new therapeutic target;non-diabetic;novel;Onset of illness;Palmitates;Palmitic Acids;palmitoylation;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phosphotransferases;Photoreceptors;Post-Translational Protein Processing;Prevalence;prevent;Process;Production;Proteins;Public Health;public health relevance;release of sequestered calcium ion into cytoplasm;Reporting;Retina;Retinal Diseases;retinal rods;Rod;Ryanodine Receptor Calcium Release Channel;Severities;Signal Transduction;Signaling Molecule;Stress;targeted treatment;Testing;Therapeutic Effect;therapy development;Tissues;Transgenic Organisms;Vision;Visual;visual cycle;Visual disability;Visual impairment

PROJECT_TITLE: Modulating retinal lipid biogenesis in diabetes for therapeutic effects


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE Globally there is an increasing number of HIV-exposed but uninfected children and adolescents (HEU). We propose to evaluate HEU in Kenya, spanning from infancy to adolescence using different epidemiologic approaches to determine whether HEU have increased risk of adverse neurodevelopmental or mental health outcomes. We plan to screen a large population of HEU nationally and work collaboratively with stakeholders to review this data to inform approaches to screen, identify, and refer HEU with adverse outcomes, that could be used programmatically.

PI_NAMEs: JOHN-STEWART, GRACE C. (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Adolescence;Adolescent;adolescent mental health;Adult;Adult Children;adverse outcome;Affect;Africa South of the Sahara;Age;age stratification;aged;Anti-Retroviral Agents;Anxiety;Assessment tool;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological Markers;Blood;Brain imaging;Caring;Child;Clinic;Clinical Data;clinically relevant;cofactor;Cognitive;cohort;Collaborations;Communities;Complement;Computerized Medical Record;Cost Analysis;cost estimate;Data;design;Development;Diagnostic;diagnostic tool;Dryness;Early Intervention;Educational workshop;efavirenz;electronic medical record system;Enrollment;Epidemiology;epidemiology study;Evaluation;experience;Exposure to;fetal;follow-up;Future;General Population;Growth;Guidelines;Health;health assessment;Hearing;HIV;HIV-exposed uninfected infant;imaging study;Income;Individual;infancy;Infant;Infection;Inflammation;insight;Intervention;Kenya;Length;Link;Longitudinal cohort;Longitudinal Studies;Medical;Medical Records;Mental Depression;Mental Health;Monitor;Morbidity - disease rate;mortality;Mother-to-child HIV transmission;Mothers;neurodevelopment;Neurodevelopmental Deficit;novel strategies;open source;Outcome;Performance;Perinatal;Persons;Pharmaceutical Preparations;Phase;pilot test;Policies;Population;population based;Pregnancy;prenatal exposure;prevent;Prevention;programs;Public Health;recruit;Regimen;Risk;rural setting;Sampling Studies;screening;Screening procedure;screening program;Site;Spottings;suicidal;Surveys;telomere;tool;treatment guidelines;Treatment Protocols;urban setting;Viral Load result;Woman;Work

PROJECT_TITLE: HEU outcomes: population-evaluation and screening strategies (HOPE)