ORG_CITY: CHICAGO

ORG_DEPT: UROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: EZH2 is a well-known histone lysine methyltransferase and an oncogene upregulated in many types of cancer, including prostate cancer. In this project, we will investigate the novel noncanonical, Polycomb-repressive complex-independent role for EZH2 in rRNA 2’-O-ribose methylation, ribosomal functions and protein synthesis via FBL. Successful completion of this project will provide novel mechanistic insights EZH2’s novel functions beyond its lysine methyltransferase and transcription repressor activities.

PI_NAMEs: CAO, QI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: advanced prostate cancer;Affect;American;androgen independent prostate cancer;Androgens;Binding;Biological Markers;Cancer Etiology;cancer initiation;Cancer Patient;cancer type;Cell Line;Cell Maintenance;Cessation of life;chemotherapy;Clinic;Clinical;Complex;Data;demethylation;Development;Disease;DNA Methylation;Embryo;Endoderm;Epigenetic Process;epigenetic regulation;Exclusion;EZH2 gene;fibrillarin;gain of function mutation;Glutamine;Histone H2A;Histone H3;histone methylation;histone methyltransferase;histone modification;Histone-Lysine N-Methyltransferase;Histones;In Vitro;in vivo;inhibitor;insight;Internal Ribosome Entry Site;knock-down;Lesion;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Messenger RNA;Methylation;Methyltransferase;MicroRNAs;Modification;Molecular;Mus;Neoplasm Metastasis;novel;novel therapeutics;Oncogenes;Oncogenic;Organoids;Outcome;overexpression;particle;patient population;Patients;Peptide Synthesis;Play;Polycomb;Polyribosomes;polysome profiling;prostate cancer cell;prostate cancer progression;Protein Biosynthesis;Proteins;Radiation therapy;recruit;Regulation;Reporting;Ribonucleoproteins;Ribose;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA Editing;RNA methylation;RNA, Ribosomal, 28S;Role;Site;Skin Cancer;Small Nucleolar Ribonucleoproteins;Small Nucleolar RNA;stem cells;Survival Analysis;Testing;Tissue Sample;TP53 gene;Transcript;Transcription Repressor;Transfer RNA;Translation Initiation;Translations;tumor progression;Untranslated RNA;Work;Xenograft Model

PROJECT_TITLE: A non-canonical role for EZH2 in rRNA methtlation

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: This program is centered on signaling mechanisms triggered by polarized protein complexes that regulate actomyosin contractions and cell movements during vertebrate early development. The proposed studies will contribute to the knowledge necessary for prevention of birth abnormalities and are relevant to metastatic cancers and other diseases linked to alterations of cell polarity.

PI_NAMEs: SOKOL, SERGEI  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Actomyosin;Biochemical;Biological;Birth;cell behavior;cell motility;Cell Polarity;Cell Shape;Cells;Cilia;Congenital Abnormality;Cues;Development;Developmental Process;Disease;Disseminated Malignant Neoplasm;Drosophila genus;Embryo;Epithelium;Event;experience;Experimental Models;gastrulation;Genes;Genetic study;Health;high resolution imaging;Homologous Gene;Human;Knowledge;Left;Link;mechanical force;Molecular;Morphogenesis;Movement;Myosin Type II;Neural Tube Closure;Pathway interactions;Pattern;planar cell polarity;polarized cell;Polycystic Kidney Diseases;Positioning Attribute;Prevention;programs;protein complex;Proteins;Proteomics;Renal Carcinoma;response;Signal Pathway;Signal Transduction;Specific qualifier value;Syndrome;System;Systems Biology;Techniques;Tissues;transcriptomics;Translating;vertebrate embryos;Vertebrates;Xenopus

PROJECT_TITLE: Cell polarity and morphogenesis in Xenopus embryos

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PI_NAMEs: KELLEHER, NEIL L (contact)

PROJECT_TITLE: Community Engagement

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T]


NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The directed movement of cargos inside cells by the molecular machines dynein and kinesin is essential for cell survival. Cell survival is also dependent on the proper repair of DNA damage caused by external factors. This research will provide fundamental insight into the workings of the molecular machines involved in these two processes.

PI_NAMEs: LESCHZINER, ANDRES  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Address;ATP Hydrolysis;Binding;Biochemistry;Biological Models;Biophysics;Catalytic Domain;Cell Nucleus;Cell Survival;Cells;Cellular biology;Chromatin;Collaborations;Complex;computerized data processing;Coupled;Cryoelectron Microscopy;Cytoskeleton;Data Collection;dimer;DNA;DNA lesion;DNA Polymerase II;DNA Repair;dynactin;Dynein ATPase;Family;Genetic Transcription;Genome;Histones;insight;interest;Kinesin;Lesion;link protein;member;Microtubules;Modification;Molecular Machines;Molecular Motors;Movement;Nucleosomes;Organelles;Orphan;Orthologous Gene;Outcome;Preparation;Process;Proteins;recruit;Regulation;repaired;Research;RNA;single molecule;Structure;System;Techniques;Testing;tool;Transcription Initiation;Yeasts

PROJECT_TITLE: Mechanism of cytoskeletal transport and transcription-coupled DNA repair

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Physical Activity;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative This project aims to develop new analytic tools for understanding how accumulation patterns of physical activ- ity, sedentary behavior and sleep in the 24-hour activity cycle are associated with health outcomes, such as cardiovascular diseases.

PI_NAMEs: DI, CHONGZHI  (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: Accelerometer;Activity Cycles;Address;advanced analytics;Advisory Committees;Affect;Aging;American;analytical method;analytical tool;Ancillary Study;Area;Behavior;biobank;Cardiovascular Diseases;cardiovascular health;Categories;Clinical Research;Collaborations;complex data;Computer software;Data;Data Analyses;Development;Devices;Diabetes Mellitus;Dose;effective intervention;Epidemiology;epidemiology study;feature extraction;flexibility;Goals;Guidelines;Health;Health Benefit;high dimensionality;Hour;improved;indexing;insight;Intervention;Length;lifestyle factors;light intensity;Longitudinal Studies;Measurement;Measures;Methodology;Methods;Modeling;mortality;National Health and Nutrition Examination Survey;Nature;novel;older women;Outcome;Pattern;Physical activity;Population Surveillance;Principal Component Analysis;programs;Reporting;response;sedentary;sedentary lifestyle;Sleep;Statistical Methods;surveillance study;Time;vigorous intensity;wearable device;Woman;Women's Health

PROJECT_TITLE: Statistical methods for analyzing objectively measured physical activity.

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: DANVILLE

ORG_NAME: GEISINGER CLINIC

ORG_STATE: PA

PHR: PROJECT NARRATIVE Recent studies of familial hypercholesterolemia suggest that the broad phenotypic definition encompasses four distinct subtypes: 1) monogenic FH caused by a pathogenic variant in an FH gene, 2) polygenic hypercholesterolemia caused by the cumulative inheritance of many common alleles associated with incremental increases in LDL-C, 3) LPA gene variants that increase levels of serum lipoprotein (a) and mimic the FH phenotype, and 4) severe hypercholesterolemia and a positive family history in the absence of a genetic cause. Distinguishing among these subtypes may have clinical importance. We propose a multi-disciplinary project to examine risk among FH subtypes and use implementation science to develop strategies for the communication of this complex information between clinicians and patients for improved cardiovascular disease prevention in FH. We propose a multi-disciplinary project to examine risk among FH subtypes and use implementation science to develop strategies for the communication of this complex information between clinicians and patients to improve cardiovascular disease prevention in FH.

PI_NAMEs: OETJENS, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: REIS, JARED P

PROJECT_TERMS: Accounting;Address;Adoption;Affect;Age;Alleles;Atherosclerosis;atherosclerosis risk;Attitude;autosome;barrier to care;biobank;blood lipid;Cardiac;cardiovascular disorder prevention;cardiovascular disorder risk;Caring;Characteristics;Cholesterol;Clinical;clinical care;clinical practice;clinical subtypes;ClinVar;cohort;Cohort Studies;Communication;Complex;Cox Proportional Hazards Models;Data;Diabetes Mellitus;Diagnosis;Disease Outcome;disease phenotype;disease prognosis;disease-causing mutation;Disparity;early onset;Equation;Ethnic Origin;Familial Hypercholesterolemia;Family;Family history of;Foundations;Gender;Genes;Genetic;Genetic Databases;genetic information;Genetic Screening;genetic variant;Genomics;Goals;Health;health disparity;Health Services Accessibility;Healthcare;high risk;hypercholesterolemia;Hypertension;implementation science;implementation strategy;improved;improved outcome;Individual;Investigation;LDL Cholesterol Lipoproteins;Lipids;Lipoprotein (a);Maintenance;Maps;medication compliance;Molecular;multidisciplinary;Outcome;outcome disparities;Pathogenicity;Patient Care;patient population;Patients;Perception;Performance;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;population based;Population Heterogeneity;Population Study;precision medicine;premature;Prevalence;prevent;Prevention;programs;Provider;Race;rare variant;Recording of previous events;response;Risk;Risk Assessment;Risk Factors;risk prediction model;risk stratification;Rural;rurality;Sampling Studies;Serum;sex;social health determinants;Techniques;theories;Time;Tobacco use;tool;translational model;Variant;Woman

PROJECT_TITLE: Improving Risk Stratification in Familial Hypercholesterolemia (RISK-FH)

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Digestive Diseases;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases;Skin Cancer

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Project Narrative This R01 grant proposal addresses a critical unmet need, exploring LPC 18:2 as a novel small molecule therapeutic for immune related adverse events (irAEs) in cancer patients undergoing immune checkpoint blockade (ICB) therapy for cancer. We are leveraging a powerful, discovery-based metabolomics platform in human cancer patients combined with mechanistic studies in humans and preclinical models to understand molecular mechanisms by which LPC 18:2 protects against ICB-driven irAEs. This study will directly enable LPC 18:2 therapy to alleviate irAEs and minimize risk, maximize benefit, and personalize cancer immunotherapy for those patients who stand to benefit from these powerful treatments.

PI_NAMEs: DENNIS, EDWARD A;SHARMA, SONIA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Ablation;Address;Affect;Aftercare;anti-CTLA4;Anti-Inflammatory Agents;anti-PD-1;Applications Grants;Autoimmune;Autoimmune Diseases;autoimmune toxicity;Autoimmunity;Biological Assay;Biology;Bone Marrow;Cancer Center;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Clinical;Clinical Trials;cohort;Colitis;Combined Modality Therapy;CTLA4 gene;Development;Disease Progression;Epidemiologist;experience;G2A receptor;Genetic;Genetic Transcription;Genomic Instability;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Hodgkin Disease;Human;human model;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune-related adverse events;Immunity;Immunological Models;Immunologics;Immunologist;Immunology;Immunomodulators;Immunooncology;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;in vivo;in vivo Model;Individual;Inflammation;Inflammatory;innovation;ipilimumab;Life;liquid chromatography mass spectrometry;Lysophosphatidylcholines;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mass Spectrum Analysis;Measures;Medical center;Melanoma;Melanoma patient;Merkel cell carcinoma;Metabolism;metabolomics;Microsatellite Repeats;Modeling;Molecular;mouse model;murine colitis;Mus;Neck Cancer;neutrophil;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Participant;Patients;pembrolizumab;Phenotype;Plasma;Play;Population;Pre-Clinical Model;progenitor;programmed cell death protein 1;prophylactic;prospective;reduce symptoms;Renal Cell Carcinoma;Research Design;restoration;restraint;risk minimization;Role;Sampling;Scientist;Serum;Signal Transduction;small molecule;small molecule therapeutics;Solid Neoplasm;Squamous cell carcinoma;success;Supplementation;System;systemic inflammatory response;targeted treatment;Therapeutic;Tissues;Toxic effect;Treatment Efficacy;tumor;tumor immunology

PROJECT_TITLE: Bioactive Metabolites Modulate Immune-Related Adverse Events in Cancer Immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Substance Misuse

ORG_CITY: Clifton

ORG_NAME: REAL PREVENTION, LLC

ORG_STATE: NJ

PHR: Project Narrative This Phase II SBIR will complete the development of the Opioid Rapid Response System (ORRS), test its efficacy for opioid overdose response, and prepare it for widespread dissemination. Overdose events require a rapid response, which is often not available through standard emergency procedures. ORRS is a system for recruiting and training citizen responders to reverse overdoses through naloxone administration that capitalizes on widely disseminated medical apps linking responders to these events.

PI_NAMEs: CHOI, HYE JEONG;HECHT, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Address;base;behavior change;Behavioral;Behavioral Model;behavioral outcome;Cardiac;Cessation of life;commercialization;commune;Communication;communication theory;Communities;Community Networks;comparative efficacy;cost;cost effective;County;Data;Dedications;design;Development;digital;digital intervention;dissemination strategy;effectiveness evaluation;Effectiveness of Interventions;Electronic Mail;Emergency response;emergency service responder;Emergency Situation;Event;evidence base;Evidence based program;Expenditure;Focus Groups;Goals;Health;Health Personnel;Health Promotion;implementation science;improved;Indiana;Individual;innovation;Innovation Corps;innovative technologies;Interview;Knowledge;lens;Life;Link;Literature;Marketing;Medical;Medical emergency;Modeling;Multimedia;multimodality;Naloxone;naloxone dispensing;Naloxone Training;Nature;Online Systems;Opioid;opioid epidemic;opioid mortality;opioid overdose;Overdose;Overdose reversal;Participant;Performance;Persons;Phase;Pilot Projects;Prevention;Procedures;Protocols documentation;prototype;psychological outcomes;Public Health;randomized trial;randomized, clinical trials;Reaction Time;Readiness;Recovery;recruit;Research;Resources;response;Rural;rural area;Sampling;Science;Small Business Innovation Research Grant;social cognitive theory;social group;social influence;social media;social stigma;Societies;Standardization;Stroke;Suicide;System;Technology;Testing;theories;Training;Training Programs;Urban Community;urban setting;usability;web site;Work

PROJECT_TITLE: Developing and testing the Opioid Rapid Response System


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Transplantation

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Organ transplantation is the preferred therapy for end stage organ failure of the heart, intestine, kidney, liver, lung, and endocrine pancreas, as well as an emerging option for patients with limb, face, and other composite tissue loss and the number of patients awaiting (currently >120,000), receiving (>28,000/year) and living with (~420,000) organ transplants has approximately doubled in the past decade; however, even as the number of patients requiring innovative, scientifically sound solutions to transplant-related problems markedly increases, the number of scientists entering the field has decreased in recent years. Newly energized, transplant-focused training is required to perpetuate the pattern of discovery that has propelled the field of transplantation, and these training opportunities need to be developed cognizant of the unique clinical integration and multidisciplinary scientific and practice patterns characteristic of modern transplantation. Collaborative scientists and clinicians at the Emory Transplant Center are proposing an integrative, multi-disciplinary training program in transplantation biology (Advanced Research Training in Transplantation Sciences, ARTTS) to accomplish this goal.

PI_NAMEs: FORD, MANDY L (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Psychosis;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE People with psychotic disorders experience a high level of functional disability, and a major contributor to this disability is introspective inaccuracy, which is defined as inaccurate judgements of one’s abilities and performance. Yet, no intervention has directly targeted introspective accuracy in psychotic illnesses. In a sequence of clinical trials, we will evaluate a new intervention, called iTEST, that is delivered on mobile devices and trains people with psychotic disorders to improve their introspective accuracy with an ultimate goal of improving daily functioning.

PI_NAMEs: DEPP, COLIN A. (contact);PINKHAM, AMY

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Adherence;Adult;Area;Attention;Basic Science;Behavior;Clinical;Clinical Trials;clinically significant;Cognition;Cognitive;cognitive capacity;cognitive rehabilitation;Cognitive remediation;cognitive testing;cognitive training;Compensation;Coupled;Cues;daily functioning;Data;design;digital health;disability;Disabling;Distal;Dose;experience;experimental study;Failure;Feedback;follow-up;functional disability;Functional impairment;functional improvement;functional outcomes;Goals;handheld mobile device;Health Priorities;improved;indexing;Individual;Intervention;intervention refinement;Investigational Therapies;Maintenance;Measures;Mediating;Mediation;Memory;Mental disorders;metacognition;mHealth;Motivation;multimodality;National Institute of Mental Health;novel;Outcome;Outpatients;Pathway Analysis;Performance;Persons;Phase;Pilot Projects;pilot test;post intervention;preventive intervention;Process;Psychological Transfer;psychosocial development;Psychotic Disorders;randomized trial;Randomized, Controlled Trials;recruit;Rehabilitation therapy;remediation;remote delivery;Research;Schizoaffective Disorders;Schizophrenia;Self Assessment;Series;Shapes;Site;skills;social cognition;Specific qualifier value;success;Symptoms;Task Performances;Technology;Testing;Therapeutic Intervention;Thinking;Time;Training;Translating;usability;Validation;Variant;Work

PROJECT_TITLE: iTEST: Introspective Accuracy as a Novel Target for Functioning in Psychotic Disorders


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Data Science;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE We propose to design and pilot test a multi-modal sensor-based approach to automate functional health assessment and provide assistance with everyday activities for individuals with Alzheimer's disease and related dementias (ADRDs). This work will demonstrate that intelligent technologies can be used in real-world settings for functional health assessment and intervention. This research is relevant to public health because these technologies can extend the functional independence of our aging society through technology-assisted health self-management, reduce caregiver burden and improve quality of life.

PI_NAMEs: COOK, DIANE JOYCE (contact);SCHMITTER-EDGECOMBE, MAUREEN

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;age effect;age related;Aging;Algorithms;Alzheimer's disease related dementia;assessment application;automated assessment;Automation;Awareness;Behavior;Caregiver Burden;Caregivers;Caring;Chronic;Classification;Clinic;Clinical;Clinical assessments;Cognitive;cognitive rehabilitation;cognitive testing;Complex;Data;Data Analytics;Data Collection;Data Sources;Dementia;design;Detection;digital;Early Diagnosis;effective therapy;Environment;Evaluation;experience;Family Planning;functional independence;functional outcomes;functional status;Future;Goals;Health;health assessment;health care availability;Health Care Costs;Health Personnel;Home;Human;Impaired cognition;improved;Individual;innovation;insight;Interdisciplinary Study;Intervention;iterative design;Knowledge;learning algorithm;learning strategy;Machine Learning;Measures;Memory;Methods;mild cognitive impairment;mobile sensor;Modeling;Monitor;multimodal data;multimodal fusion;multimodality;novel;older adult;Older Population;Outcome;Participant;Patient Self-Report;Performance;Persons;pilot test;Population;Public Health;Quality of life;Research;research clinical testing;Role;Self Management;sensor;sensor technology;Services;smart environment;smart home;Societies;Source;System;Techniques;Technology;Testing;Text;Time;Validation;Video Recording;Work

PROJECT_TITLE: Multi-modal functional health assessment and intervention for individuals experiencing cognitive decline


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: RICHMOND

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Although astrocytes play critical functions in the brain, mechanisms controlling their diversity remain mostly elusive. We found that an architectural transcription factor Yin Yang 1 exerts differential effects on subpopulations of astrocytes in cerebellum. We will establish its effects on the major functions of cerebellar astrocyte subpopulations and obtain insights into the molecular mechanisms of its action.

PI_NAMEs: KORDULA, TOMASZ K (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Affect;Agreement;AMPA Receptors;Architecture;astrocyte progenitor;Astrocytes;astrogliosis;Biology;Birth;Blood - brain barrier anatomy;Brain;Brain region;Calcium;Cell Differentiation process;Cells;Cerebellum;Characteristics;Chromatin;Chromatin Loop;Communication;Data;Development;differential expression;DNA Binding;Epigenetic Process;experimental study;Fibrous Astrocyte;Gap Junctions;Gene Expression;Gene Expression Profile;Genes;Glial Fibrillary Acidic Protein;Gliosis;histone modification;Hypertrophy;in vivo;insight;Ion Channel;Knockout Mice;Messenger RNA;Microglia;Modification;Molecular;Morphology;motor deficit;Motor Skills;Mus;Myeloid Cells;nerve stem cell;neural;neuroepithelium;Neuroglia;neuronal circuitry;Neurons;Neurotransmitters;Normal Statistical Distribution;novel;novel strategies;Oligodendroglia;Pattern;Play;postnatal;Process;progenitor;Program Sustainability;programs;Proliferating;Purkinje Cells;recruit;Regulation;Resolution;SHH gene;single-cell RNA sequencing;Slide;stem cell differentiation;Subgroup;Synapses;synaptogenesis;Testing;transcription factor;Translating;white matter;YY1 Transcription Factor

PROJECT_TITLE: Regulation of astrocyte diversity in the cerebellum

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Aging

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE The National Institute on Aging (NIA) has funded the RAND Postdoctoral Training Program in the Study of Aging over five five-year cycles. We propose five more years of support for two postdoctoral fellows per year, beginning in 2021. RAND offers a rich and unique environment for advanced training in the study of aging—one characterized by a strong emphasis on interdisciplinary research, supported by 9 Centers dedicated to the study of myriad issues of relevance to aging, a diverse and distinguished group of scholars and mentors, excellent facilities and strong research support services, and the availability of formal instruction in research skills that postdoctoral fellows will need to productively advance in their careers.

PI_NAMEs: SHIH, REGINA A (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: RAND Postdoctoral Training Program in the Study of Aging Renewal


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE Oral squamous cell carcinoma (OSCC) is a deadly cancer with high relapse rates and poor responses to immune checkpoint inhibitors, and current treatment results in reducing the patient’s quality of life. However, the generation of new compounds designed to target for degradation specific intracellular proteins opens previously inaccessible avenues to treat OSCC and particularly those that have inactivated the tumor suppressor p53, which makes them more aggressive and difficult to treat. We generated a novel degrader to target a newly uncovered vulnerability in OSCC and propose studies that should ultimately lead to improved therapeutic intervention for this deadly malignancy.

PI_NAMEs: EISCHEN, CHRISTINE M. (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Affinity;Apoptosis;Automobile Driving;Belief;Binding;Biochemical;cancer cell;carcinogenesis;Cell Cycle;Cell Death;Cell Death Signaling Process;cell killing;Cell Line;Cells;Cessation of life;checkpoint inhibition;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;cytotoxicity;Data;Dentists;Dependence;design;Development;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;effective therapy;Effectiveness;Embryonic Development;experience;Generations;Genes;Growth;Head and Neck Cancer;HPV negative;Human;Human Papillomavirus;Immune;Immune Cell Suppression;Immune checkpoint inhibitor;Immunocompetent;immunogenic;immunogenicity;improved;in vivo;Incidence;innovation;insight;Interferon Type I;knock-down;Knockout Mice;Laboratories;Malignant Epithelial Cell;Malignant Neoplasms;Metabolic;Molecular;mouse model;mouth squamous cell carcinoma;Mus;mutant;mutant mouse model;Mutation;neoplastic cell;Normal Cell;novel;novel therapeutic intervention;Oncogenes;Oral;Pathway interactions;Patients;Positioning Attribute;preclinical evaluation;Preclinical Testing;Proliferating;Protac;Proteins;Quality of life;Reagent;Relapse;Resistance;response;routine care;Sampling;Signal Transduction;Site;small hairpin RNA;Stimulator of Interferon Genes;Survival Rate;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Intervention;therapy resistant;three dimensional cell culture;TP53 gene;Translating;tumor;tumor-immune system interactions;tumorigenic;Validation;Xenograft procedure

PROJECT_TITLE: Investigating a new vulnerability in oral squamous cell carcinoma

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: PROJECT NARRATIVE Neurological disorders are a burgeoning epidemic and Low middle-income countries (LMICs) like Uganda have limited capacity to address them. Research training in LMICs provides an avenue to address and build capacity for locally research aimed at preventing and controlling neurological disorders. Leveraging on a successful collaboration with Case Western Reserve University and through a Multiple Principal Investigator application, we propose a plan for a comprehensive multi-disciplinary research-training program for neurological disorders across the lifespan in Uganda. !

PI_NAMEs: KADDUMUKASA, MARK  (contact);KATABIRA, ELLY T;SAJATOVIC, MARTHA X

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Address;Area;Award;Bioethics;brain health;burden of illness;Chronic;clinical care;college;Country;Data;Development;Disease;Doctor of Philosophy;Environment;Epidemiology;experience;Faculty;Fellowship;good laboratory practice;Grant;Health Sciences;implementation science;Infrastructure;Institution;International;Joints;life span;low and middle-income countries;Manuscripts;Medical Education;Mental Health;Mentors;Mentorship;Nervous System Disorder;neurogenetics;Neurologic;Neurology;Neurosciences;neurosurgery;Outcome;Policies;Principal Investigator;Public Health;Qualitative Research;Research;Research Methodology;Research Personnel;Research Support;Research Training;Support System;System;Training;Training Programs;Traumatic Brain Injury;Uganda;Universities;Writing

PROJECT_TITLE: Research training and mentorship to strengthen brain health across the lifespan in Uganda.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-S(02)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Diabetes;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Pediatric;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The elevated risk of coronary artery disease (CAD) in type 1 diabetes remains largely unexplained by established risk factors. We aim to identify new pathways to CAD in type 1 diabetes through studying genetic variants and novel inflammatory and immune response biomarkers in subgroups of people who are particularly susceptible and resistant to CAD.

PI_NAMEs: MILLER, RACHEL GRACE (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: 17 year old;Address;Age Years;Biological;Biological Markers;Blood Pressure;Blood Vessels;burden of illness;Candidate Disease Gene;Cardiovascular system;case control;Cessation of life;Childhood;Clinical Data;clinical risk;cohort;Complications of Diabetes Mellitus;Coronary;Coronary Arteriosclerosis;Coupling;Data;design;Development;Diabetes Mellitus;Disease;Disease Pathway;disease phenotype;Disease Resistance;Disease susceptibility;disorder risk;DNA Methylation;Electrocardiogram;Epidemiology;Etiology;Event;follow-up;Future;gene discovery;Genes;Genetic;Genetic Code;Genetic Predisposition to Disease;Genetic study;genetic variant;genome sequencing;genome wide association study;Goals;Heterogeneity;high risk;Immune response;Immune Response Genes;Inflammation;Inflammatory;Inflammatory Response;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;Intervention;Ischemia;Kidney Diseases;Lipids;Measurement;Measures;Mediating;Mediation;Mendelian randomization;multiple omics;Myocardial Infarction;Natural History;novel;novel marker;novel therapeutic intervention;Outcome;Pathway interactions;Persons;pharmacologic;Phenotype;Population;Populations at Risk;Predisposition;Prevalence;prevent;prospective;Proteins;Proteomics;Reporting;Resistance;response biomarker;revascularization;Risk;Risk Factors;Risk Reduction;risk variant;Sample Size;Sampling;Specimen;Subgroup;targeted biomarker;Testing;trend;Variant;Vascular Diseases;whole genome

PROJECT_TITLE: Examining Susceptibility and Resistance Phenotypes to Enhance Understanding of the Genetic Basis of Major Coronary Artery Disease in Type 1 Diabetes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Epilepsy can be the harbinger of the aging brain and the third most common neurological disorder in the elderly with up to half of new onset cases with no identifiable cause. This work seeks to understand the causes and cognitive trajectory of late onset unexplained epilepsy (LOUE) by exploring the burden of Alzheimer’s disease and cerebrovascular markers and whether epilepsy related factors worsen these pathologies and cause accelerated cognitive decline. This area of research is especially relevant given the aging population and the importance of identifying treatment targets that can prevent and treat LOUE, and the work’s findings can be applied to diseases where seizures are a common comorbidity such as Alzheimer’s disease.

PI_NAMEs: SARKIS, RANI  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acceleration;Advisory Committees;Affect;Age;aggressive therapy;Aging;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Animals;Anticonvulsants;Area;behavioral neurology;Biological Markers;Blood;Blood Vessels;Brain scan;career;career development;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;Clinical;Clinical assessments;Cognition;Cognitive;cognitive performance;cohort;Collaborations;comorbidity;comparison control;Control Groups;Cross-Sectional Studies;Data;Databases;Dementia;dementia risk;diaries;Disease;Elderly;Enrollment;Environment;Epilepsy;executive function;Exhibits;follow-up;Fostering;Functional disorder;Funding;Future;General Hospitals;Goals;Grant;high risk;Hippocampus;Hospitals;human data;human old age (65+);Hyperactivity;hyperphosphorylated tau;Impaired cognition;in vitro Model;Individual;individual patient;Institution;Ischemia;Lead;Life Expectancy;Liquid substance;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Massachusetts;Measures;medical schools;Mentors;Mentorship;Microvascular Dysfunction;multimodal neuroimaging;Natural History;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neurons;neuropathology;Neuropsychology;older adult;older patient;Participant;Pathology;Patients;peer;Plasma;Positioning Attribute;prevent;Preventive;prospective;Public Health Schools;recruit;Recurrence;Research;Research Personnel;Resources;Risk;Seizures;Severity of illness;Societies;Statistical Data Interpretation;Stroke;tau Proteins;tau-1;Testing;Therapeutic;Training;United States National Institutes of Health;Vascular Cognitive Impairment;vascular injury;verbal;visual memory;Woman;Work;World Health

PROJECT_TITLE: The Contribution of Late Onset Unexplained Epilepsy to Cognitive Decline and its Interaction with Vascular and Alzheimer's Disease Pathologies

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: HIV/AIDS;Pediatric;Pediatric - AIDS

ORG_DEPT: PEDIATRICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Advancement in child health is threatened by the decline and limited diversity of pediatrician-scientists in the biomedical workforce. The Pediatric Scientist Development Program (PSDP) has implemented a comprehensive strategy to expand the boundaries of child health research and develop the research careers of rigorously trained, diverse pediatric physician-scientists. The PSDP's primary goal is to produce the next generation of diverse investigative pediatricians who will discover the causes and cures of childhood illnesses, recognizing that a diverse group of pediatrician physician-scientists is better equipped to address health issues affecting all communities and achieve maximum health impact.

PI_NAMEs: PERMAR, SALLIE R. (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Biomedical Research;career;career development;Child Health;Childhood;clinical training;Development;Disease;diversity and equity;Education;Educational Curriculum;experience;Faculty;Fellowship;flexibility;flipped classroom;Foundations;frontier;Funding;Future;Goals;Grant;health equity;Healthcare;HIV;Hybrids;innovation;Intramural Research;Lead;Medicine;Mentors;Modification;National Institute of Child Health and Human Development;next generation;novel;pediatric department;Pediatric Research;pediatrician;pediatrician scientist;peer coaching;Physicians;Program Development;programs;Recording of previous events;recruit;Research;Research Training;Scholars Program;Science;Scientist;synergism;Training;Training Programs;United States National Institutes of Health;virtual platform;Work

PROJECT_TITLE: Pediatric Scientist Development Program


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Hematology;Machine Learning and Artificial Intelligence;Physical Injury - Accidents and Adverse Effects

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Injury is the most common cause of death in people under 46 years old with more than 200,000 Americans dying annually. Bleeding accounts for 30% of deaths after injury, most of which are preventable if patients receive timely bleeding treatments including procedures to stop the bleeding as well as medications and blood transfusions to prevent blood thinning. The proposed resarch will understand how bleeding after injury is managed in hospitals that do and do not specialize in injury care, identify the reasons patients do not get timely treatment, and then create an improved systematic process by engaging key stakeholders from across the spectrum of hospitals caring for injured people.

PI_NAMEs: STEY, ANNE M (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Accident and Emergency department;Adherence;Age Years;Algorithms;American;American College of Surgeons;Anticoagulants;Area;Bleeding time procedure;Blood Coagulation Disorders;Blood Pressure;blood product;Blood Transfusion;Caring;Cause of Death;Cessation of life;Chicago;Clinical;clinical care;Clinical Data;Clinical Trials;Data;data modeling;data registry;Data Science;design;Devices;Emergency medical service;Emergency Medical Technicians;Engineering;Ensure;Failure;Future;Goals;Guidelines;Health;Healthcare Systems;Hemorrhage;Hemostatic Agents;high risk;hospital care;Hospitals;Hour;Illinois;improved;injured;Injury;Intervention;Interventional radiology;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Life;Machine Learning;Maps;Methods;Minor;mortality;Operative Surgical Procedures;Outcomes Research;Patient Care;patient oriented;Patient Transfer;Patient Triage;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physiological;pilot test;Practice Management;prevent;preventable death;Procedures;Process;programs;Protocols documentation;prototype;Provider;Randomized, Controlled Trials;Research;Resources;Resuscitation;severe injury;Standardization;standardized care;stroke patient;supervised learning;System;Testing;Time;time use;Training;Trauma;trauma care;trauma centers;Trauma patient;trauma surgery;Traumatic injury;Triage;United States;user centered design;Work

PROJECT_TITLE: Timeliness of Management of Trauma Related Hemorrhage and Trauma Related Coagulopathy

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Prevention;Rehabilitation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative This research explores the relationships between anemia and multi-dimensional functional recovery in survivors of critical illness, including recovery of physical function, cognition, mental health, and quality of life. Anemia is a common consequence of critical illness and may represent a modifiable risk factor for functional recovery, which is impaired in millions of annual survivors of critical illness. In this research, we test a multifaceted intervention to prevent and treat anemia during critical illness and examine the impact on post- hospitalization functional outcomes.

PI_NAMEs: WARNER, MATTHEW A (contact)

PROJECT_TERMS: Acute;Admission activity;Adoption;Anemia;Applications Grants;Attenuated;attenuation;Biometry;clinical decision support;clinical predictors;Clinical Trials;Clinical Trials Design;Cognition;cohort;Complication;Critical Care;Critical Illness;Data;Data Science;Development;Dimensions;epidemiologic data;Erythrocyte Transfusion;experience;feasibility testing;functional outcomes;Future;Goals;Hemoglobin;Hemoglobin concentration result;high risk;Hospitalization;Hospitals;Illness impact;Impairment;implementation science;improved;Intensive Care Units;Intervention;Knowledge;Mental Health;Methodology;modifiable risk;Modification;mortality;multi-component intervention;multidisciplinary;novel;Outcome;Outcome Assessment;Outcomes Research;Patient Discharge;patient oriented;Patient Outcomes Assessments;patient population;Patients;Pattern;pharmacologic;Physical Function;physical impairment;Pragmatic clinical trial;Predictive Factor;prevent;Prevention;Quality of life;Recovery;Recovery of Function;Research;Research Priority;Risk Factors;Scientist;success;Survivors;Techniques;Testing;therapy design;Training;translational physician;United States;Venous blood sampling

PROJECT_TITLE: Attenuation of Anemia for the Optimization of Post-Hospitalization Functional Recovery in Survivors of Critical Illness


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Machine Learning and Artificial Intelligence;Orphan Drug;Osteoporosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This project will contribute to improved public health by helping understand how abnormalities in the Gs signaling pathway cause abnormal bone growth and affect fracture repair. The new knowledge will validate new tools for studying human bone formation and repair, and identify key mechanisms that could be targeted as future treatments for diseases of bone loss or for fracture repair.

PI_NAMEs: HSIAO, EDWARD C (contact);NISSENSON, ROBERT

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acceleration;Address;Affect;analytical method;Artificial Intelligence;Automobile Driving;Binding;Biological Assay;Biology;biomarker identification;bone;Bone callus;bone cell;Bone Diseases;bone fracture repair;Bone Growth;bone loss;bone repair;bone turnover;Calvaria;cell type;Cells;Clinical;Complex;computational intelligence;Cre driver;Cyclic AMP;Data;digital;Disease;DNA Sequence Alteration;effective therapy;experience;Fibrous Dysplasia;Foundations;Fracture;Functional disorder;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Expression Profile;Genes;Genetic;genetic approach;GNAS gene;GTP-Binding Protein alpha Subunits, Gs;guanine nucleotide binding protein;Health;Hematopoietic stem cells;Homeostasis;Human;human induced pluripotent stem cells;Hybrids;Hyperactivity;improved;in vivo evaluation;Individual;Institution;Isoproterenol;Kinetics;Knowledge;Lead;Lesion;Ligands;McCune-Albright Syndrome;Mediating;Medical;Modeling;Molecular;Molecular Probes;mouse model;Mus;Musculoskeletal Diseases;Mutation;Natural regeneration;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Osteitis Fibrosa Disseminata;Osteoblasts;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;overexpression;parathyroid hormone-related protein;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Physiology;prevent;Production;Property;Proteins;PTH gene;Public Health;rare condition;receptor;Recombinants;repaired;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;skeletal;skeletal stem cell;stem cell function;stem cell model;Testing;Therapeutic;therapeutic target;tool;transcriptome;transcriptomics;treatment strategy;Variant;Wnt proteins;WNT Signaling Pathway;WNT4 gene;WNT9A gene;Work

PROJECT_TITLE: Novel Strategies for Understanding and Treating Fibrous Dysplasia

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Low physical activity after hospitalization mediates many harms associated with acute illness in older adults such as new disability, increased health care utilization, and higher costs of care. In this study we will use behaviorally designed gamification and social support through personalized coaching to implement scalable interventions to engage older adults in activity during recovery from acute illness and hospitalization. The study also aims to reduce disability and acute and post-acute care utilization as well as to promote long-term habits of healthy activity in aging adults with chronic medical conditions.

PI_NAMEs: GREYSEN, SCOTT RYAN (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: 2 arm randomized control trial;Acute;acute care;Admission activity;Adult;Affect;Age;Aging;Ambulatory Care;American;Beds;Behavior;Behavioral;behavioral economics;Behavioral Sciences;care costs;Chronic;Chronic Care;clinical implementation;Clinical Trials;cohort;Communities;comparison control;cost;cost effective intervention;COVID-19;Dangerousness;Databases;design;Diabetes Mellitus;disability;disability risk;Disablement;Discipline of Nursing;Economics;effective intervention;Effectiveness;effectiveness evaluation;Emergency department visit;Enrollment;Ethnic Origin;experience;Family;follow-up;Friends;functional disability;Future;Geriatrics;Goals;Habits;Health;health care service utilization;Health system;Heart failure;hospital readmission;Hospitalization;Hospitals;human old age (65+);Hypertension;Immobilization;imprint;improved;improved mobility;Incentives;Individual;innovation;Intervention;intervention participants;Interview;Measures;Mediating;Medical;Medicine;Methods;middle age;Mobility decline;Mobility disability;mortality;multidisciplinary;novel;novel strategies;Observational Study;older adult;Patient Discharge;patient engagement;Patients;Performance;Physical activity;physically handicapped;Pilot Projects;Population;Populations at Risk;prevent;primary outcome;process evaluation;prospective;Psychology;public health relevance;Race;Randomized;randomized trial;Recovery;remote monitoring;response;Risk;Sampling;Science;secondary outcome;Short term disability;social;social engagement;Social Network;Social support;socioeconomic diversity;success;Surveys;Testing;therapy design;Time;treatment arm;United States;virtual health;Walking;wearable device;Work

PROJECT_TITLE: A Randomized Trial of Gamification and Coaching to Improve Mobility after Hospitalization

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Alzheimer’s Disease, a neurodegenerative condition ultimately leading to cognitive decline and dementia, can present in a variety of time courses and symptoms in different individuals. We aim to explore the consequences on the function of brain cells of different variation in human DNA that contribute to Alzheimer, using a combination of work in cell culture, human tissue and analysis of large-scale information. Ultimately, this will allow us to characterize the mechanisms by which combinations of changes in DNA lead to different manifestations of the manifestations of Alzheimer.

PI_NAMEs: DE JAGER, PHILIP L (contact);ST GEORGE-HYSLOP, PETER HENRY

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease pathology;Astrocytes;Biological Assay;Biological Models;Brain;brain cell;Cell Culture Techniques;cell type;Cells;Cerebrospinal Fluid;Clinical;Clinical Data;clinical phenotype;Code;Cognition;Communities;Complex;CRISPR screen;Data;Data Analyses;data and analysis portal;data modalities;Data Set;Databases;demented;Dementia;Disease;Disease Progression;Disease susceptibility;Dissection;DNA;endophenotype;Epigenetic Process;epigenomics;Evaluation;Event;experimental study;functional genomics;Future;Generations;Genes;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic locus;Goals;Heterogeneity;Human;human DNA;human tissue;Impaired cognition;in silico;In Situ;In Vitro;in vivo;Individual;induced pluripotent stem cell;intercellular communication;Intervention;Lead;Link;Location;Maps;Measures;Microglia;Modeling;Molecular;morphometry;Multiomic Data;multiple omics;Natural Selections;Nerve Degeneration;network models;neural;Neurons;Nodal;novel;Nucleic Acid Regulatory Sequences;Onset of illness;Outcome;Outcome Measure;Peptides;precision medicine;Predisposition;programs;Proteins;Proteomics;Quantitative Trait Loci;Research;Risk Factors;Role;Sampling;Specific qualifier value;stem cell model;Susceptibility Gene;Symptoms;synergism;System;Time;Tissue Stains;Tissues;trait;transcriptomics;Variant;Work

PROJECT_TITLE: Alzheimer variants: Propagation of shared functional changes across cellular networks


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE: The primary neuropathological hallmarks of Alzheimer’s disease (AD) begin to accumulate in the brain decades before clinical symptoms emerge, making it difficult to properly model AD using short-lived animal models, such as mice. The overall goal of this project is to optimize, validate, and characterize seeding the brains of aging common marmosets with the tau protein to accelerate the onset of memory loss and cognitive impairment due to AD-related pathology. These marmosets will be invaluable in translational research aimed at elucidating the pathogenic mechanisms of AD and contribute to the development of new therapeutics for AD.

PI_NAMEs: SILVA, AFONSO C (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Acceleration;Age;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapeutic;Alzheimer’s disease biomarker;American;Amyloid beta-Protein;Animal Model;Behavior;behavior test;Behavioral;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Callithrix;Callithrix jacchus jacchus;Cell Culture Techniques;Cell Death;Cerebrovascular Circulation;Clinical;Clinical assessments;clinical biomarkers;Clinical Data;Cognitive;cognitive process;cognitive testing;cohort;comparative efficacy;cytokine;Data;Dementia;Development;Disease Progression;efficacy evaluation;entorhinal cortex;Evaluation;experimental study;extracellular;Female;Fibroblasts;Future;Genetic;Genetic Variation;Goals;Hippocampus;Human;hyperphosphorylated tau;Image;Impaired cognition;Impairment;improved;In Vitro;in vivo evaluation;Injections;intravenous administration;Late Onset Alzheimer Disease;Light;Magnetic Resonance Imaging;male;Maps;MAPT gene;Measures;Memory Loss;Metabolism;Modeling;Motor;Mus;Nerve Degeneration;nerve stem cell;neurofibrillary tangle formation;Neurofibrillary Tangles;neurofilament;Neurons;neuropathology;nonhuman primate;novel therapeutics;Pathogenicity;Pathologic;Pathology;Persons;Phenotype;Plasma;Positron-Emission Tomography;Protein Fragment;Recombinant adeno-associated virus (rAAV);Rodent Model;Senile Plaques;Sensory;Serotyping;Severities;skin biopsy;social;spatiotemporal;Staging;Symptoms;tau aggregation;tau Proteins;Testing;Time;transcriptomics;Transfection;translational potential;Translational Research;translational study;Validation;Work

PROJECT_TITLE: Development and Validation of a Marmoset Model of Late-Onset Alzheimer Disease Based on Tau Seeding


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Calcium-mediated signaling through inositol 1,4,5-triphosphate receptors (IP3Rs) is essential for the regulation of numerous physiological processes. Deregulation of IP3Rs leads to pathological changes in calcium signaling and is implicated in the pathogenesis of diverse diseases including cancer, neurodegenerative, autoimmune, and metabolic diseases. The goal of the proposed study is to elucidate the molecular mechanism of IP3R activity and regulation paving the road for development of novel therapeutic agents to control IP3R activity in the diseased state.

PI_NAMEs: KARAKAS, ERKAN  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Affinity;Agonist;Apoptosis;Architecture;Autoimmune Diseases;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;Calcium;Calcium Signaling;Cell division;cell type;Coupled;Cryoelectron Microscopy;Cytoplasm;Data;desensitization;Development;Disease;Distant;Electrophysiology (science);Endoplasmic Reticulum;Fluorescence;Gene Expression;Goals;Growth Factor;Hormones;Human;Image;Inositol;insight;Ion Channel Gating;ITPR1 gene;Learning;Ligands;Liposomes;Malignant Neoplasms;Mediating;Membrane;Memory;Metabolic;Metabolic Diseases;Mitochondria;Molecular;Molecular Conformation;Motility;mutant;Neurodegenerative Disorders;Neurotransmitters;novel;novel therapeutic intervention;novel therapeutics;patch clamp;Pathogenesis;Pathologic;Peptides;pharmacologic;Physiological;Physiological Processes;Positioning Attribute;positive allosteric modulator;programs;Property;protein aminoacid sequence;Publishing;receptor;Receptor Inhibition;Regulation;release of sequestered calcium ion into cytoplasm;Research;Resolution;Role;Signal Transduction;Site;small molecule;structural determinants;Structure;Synaptic Transmission;Testing;Therapeutic Agents;tool;trafficking;tripolyphosphate;X-Ray Crystallography

PROJECT_TITLE: Structure and function of inositol triphosphate receptors

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Mexican adolescents are at a greater risk of attempting and dying from suicide than ever before. We will culturally adapt, implement, and pilot test the Socio-Cognitive-Behavioral Therapy Protocol for Suicidal Behaviors (SCBT-SB), a culturally centered CBT protocol, among suicidal adolescents in Mexico City. This will be the first time that SCBT-SB, an evidence-based practice for suicidal ideation and behaviors, developed with the support of the NIMH, will be used with mental health providers in the public health sector in Mexico.

PI_NAMEs: DIAZ, LINA CASTRO ;DUARTEVELEZ, YOVANSKA  (contact)

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: access disparities;Address;Admission activity;Adolescent;Age;Award;Behavior Therapy;boys;Caregivers;Cessation of life;Cities;Client;Clinical;Clinical Research;Cognitive Therapy;Consumer Satisfaction;coping;cultural health;Data;depressive symptoms;Elements;Evidence based practice;Evidence based treatment;Exploration, Preparation, Implementation, and Sustainment;Exposure to;Feedback;Feeling suicidal;Female;Future;Goals;health care availability;Health Personnel;Health system;Hispanic;Hospitals;Household;implementation evaluation;implementation facilitators;implementation framework;implementation process;improved;Income;Inpatients;interest;Intervention;Interview;Knowledge;Latinx;low and middle-income countries;Low income;Manuals;Measures;Mental Health;Mental Health Services;Mexican;Mexico;Mission;Modeling;National Institute of Mental Health;Outcome;Outpatients;overtreatment;Participant;Patients;Personal Satisfaction;Phase;pilot test;Population;premature;prevent;Process;Protocols documentation;Provider;psychosocial;Psychotherapy;Public Health;Public Hospitals;Randomized, Controlled Trials;reducing suicide;Reporting;Research;Research Personnel;Resolution;response;Risk;Service setting;Services;sobriety;Spanish;suicidal;suicidal adolescent;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;Suicide prevention;suicide rate;Surgeon;Surveys;System;Teenagers;Testing;Time;Training;treatment as usual;treatment effect;Treatment Protocols;uptake;Withdrawal;Work;Youth

PROJECT_TITLE: Implementation and pilot testing of a culturally centered CBT protocol for suicidal behaviors  among youth in Mexico City

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Charcot-Marie-Tooth disease (CMT) includes many forms of inherited peripheral neuropathy and affects 1:2500 people. There is no approved treatment for any of the one-hundred genetic subtypes of CMT, representing a large unmet clinical need. Here we are proposing to optimize a gene therapy approach for CMT type 2D that will apply to all patients with dominant mutations in the glycyl tRNA synthetase (GARS) gene.

PI_NAMEs: BURGESS, ROBERT W. (contact);HARPER, SCOTT Q

PROGRAM_OFFICER_NAME: ROOF, REBECCA

PROJECT_TERMS: adeno-associated virus 9 delivery;Affect;Age;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Anticodon;Behavioral;Binding;Binding Proteins;Biochemistry;biological adaptation to stress;Biological Assay;Biological Products;Blood - brain barrier anatomy;Bypass;Capsid;cell type;Charcot-Marie-Tooth Disease;Charge;Clinical;Clinical Trials;clinically relevant;Codon Nucleotides;cohort;Collection;Data;Defect;design;disease model;DNA Polymerase III;dominant genetic mutation;Dose;Drosophila genus;Engineering;Enzymes;GARS gene;Gene Family;gene replacement therapy;gene therapy;Genes;Genetic;Genetic Recombination;Genetic study;Genome;Glycine;Glycine-Specific tRNA;Goals;Histologic;Housekeeping Gene;Human;improved;in vivo;in vivo evaluation;Incidence;Inherited;Intrathecal Injections;Intravenous;knock-down;Length;Liver;Messenger RNA;MicroRNAs;Modeling;Molecular;Motor;Motor Neurons;mouse model;Mus;mutant;Mutation;neonate;Nerve;Nervous System;Neurons;Neuropathy;neurophysiology;Outcome;overexpression;Paper;Patients;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Phase;Phenotype;Positioning Attribute;preclinical study;prevent;programs;promoter;Ribosomes;Risk;RNA;RNA Sequences;Route;Science;Sensory;Spinal Muscular Atrophy;success;Testing;Tissues;Transfer RNA;Transgenic Organisms;Translational Research;Translations;Tropism;vector

PROJECT_TITLE: tRNA Gene Replacement Therapy for tRNA-Synthetase Related Charcot-Marie-Tooth Disorder

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_CITY: MBARARA

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Narrative Suicide is one of the leading causes of death worldwide with disproportionately higher rates in developing countries and far reaching impact on families, friends and communities. Uganda with a large rural based population, requires implementation of evidence-based interventions in order to address the burden of suicide and its prevention in rural Uganda. Thus, the proposed implementation strategy consisting of WHO LIVE LIFE guide with DHMT as Champions for Suicide Prevention in rural Uganda (WLLDC-SP), will pilot test a culturally appropriate innovative evidence-based interventions for suicide prevention to reduce the risk of suicide and SIB, and/or NSSI and promote resilience for people across the life span in rural Uganda and LMICs.

PI_NAMEs: RUKUNDO, GODFREY ZARI (contact);WAKIDA, EDITH

PROJECT_TERMS: Address;Adoption;Alcohol abuse;authority;Awareness;beneficiary;Cause of Death;Communities;Community Actions;community engagement;Community of Practice;Competence;completed suicide;Country;Data;Data Analyses;Dementia;design;Developing Countries;Disease;Ecosystem;Effectiveness;effectiveness/implementation study;Emergency Situation;Epilepsy;Evaluation;Evidence based intervention;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Faculty;Family;Feasibility Studies;Feeling suicidal;Focus Groups;follow-up;Friends;Funding;Future;Grant;Hand;Health;health data;health management;Health system;Healthcare;implementation design;implementation outcomes;implementation science;implementation strategy;innovation;Intervention;Interview;Investments;Knowledge;Leadership;Life;life span;Local Government;low and middle-income countries;male;Manuals;Measures;member;Mental disorders;Mental Health;modifiable risk;Monitor;National Institute of Mental Health;Nervous System Disorder;non-suicidal self injury;Outcome;Perception;Persons;Pesticides;pilot test;population based;preference;Preparation;Prevalence;Prevention;Prevention Measures;prevention practice;Prevention strategy;preventive intervention;primary outcome;promote resilience;prototype;Psychiatrist;Recommendation;Records;Reporting;Research;Research Support;response;Risk Factors;Risk Reduction;Rural;rural area;Science;secondary outcome;Site;Structure;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;Supervision;Technology;Testing;Training;Uganda;United States National Institutes of Health;Universities;Virginia;working group;World Health Organization;young adult

PROJECT_TITLE: Pilot feasibility study of the WHO LIVE LIFE guide with DHMT as Champions for Suicide Prevention (WLLDC-SP)


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Canavan disease (CD) is an autosomal recessive inherited leukodystrophy caused by the mutations in ASPA gene encoding the aspartoacylase enzyme, leading to loss of enzyme activity and increased concentrations of its substrate N-acetylaspartate (NAA) in the brain. Currently, there is no cure or disease-modifying treatment for CD. The main objective of this project is to identify a brain-penetrant N-acetyltransferase 8-like (NAT8L) inhibitor and establish the therapeutic utility of NAT8L inhibition for the treatment of CD using a murine model, aiming at bringing a novel treatment option that can potentially delay or slow the progression of CD.

PI_NAMEs: SLUSHER, BARBARA STAUCH;TSUKAMOTO, TAKASHI  (contact)

PROJECT_TERMS: Acetyl Coenzyme A;Acetyltransferase;Age;Anabolism;Animals;aqueous;Aspartate;Aspartoacylase;assay development;Attenuated;autosome;Biochemical;Biological Assay;blood-brain barrier penetration;Body Weight;Brain;Brain Edema;Canavan Disease;carboxylate;Cessation of life;Child;Clinical;CNS degeneration;Cognitive deficits;detection assay;Development;Disease;Dose;drug discovery;Drug Kinetics;drug metabolism;early onset;effective therapy;efficacy study;enzyme activity;Enzymes;Exhibits;Funding;Gait;Genes;Genetic;Gliosis;Histopathology;Human;In Vitro;in vivo;Inherited;inhibitor;Lead;lead optimization;leukodystrophy;Life;Liver;Macrocephaly;Measurement;Metabolic;Monitor;Motor;motor deficit;mouse model;Mus;Mutation;Myelin;myelination;N-acetylaspartate;NAT1 gene;neuron loss;novel;Oligodendroglia;Pathology;Patients;Pharmaceutical Chemistry;Pharmacodynamics;pharmacologic;Pharmacology;Phase;Plasma;prevent;Prion Diseases;Property;Radioactivity;Regimen;Reporting;Research Personnel;screening;small molecule;Solubility;Structure-Activity Relationship;Substrate Specificity;Symptoms;Teenagers;Testing;Therapeutic;Therapeutic Effect;Tissues;white matter

PROJECT_TITLE: Development of NAT8L inhibitors for the Treatment of Canavan Disease

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Machine Learning and Artificial Intelligence;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: PROJECT NARRATIVE Pre-release medication for opioid use disorder (MOUD) and peer navigation (PN) represent promising strategies for improving re-entry outcomes, but there is great need for better understanding of implementation, utilization, and outcomes of these interventions. Large-scale implementation of these programs across NJ's 11 state prisons, together with established state/university partnerships and innovative linkage across clinical and administrative datasets, creates a unique research opportunity to develop and disseminate knowledge on these interventions over time that can inform translation and adaptation across states. Among releasees with SUDs, the study will: 1.) examine patterns/predictors of pre-release and post-release MOUD and PN; 2.) examine recovery outcomes over the re-entry period and their relationship to peer navigation and MOUD, separately and jointly, utilizing innovative event history analyses incorporating propensity scoring and machine learning strategies; and 3.) analyze, document, and disseminate experiences of implementation and adaptation of PN and MOUD from the perspectives of multiple stakeholders.

PI_NAMEs: CRYSTAL, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: MULFORD, CARRIE FRIED

PROJECT_TERMS: Acute;Admission activity;adverse outcome;Advocate;Cessation of life;Clinical;cohort;Communities;community reentry;Criminal Justice;Data;Data Set;Databases;Decision Making;Dimensions;Disease;Disparity;Dissemination and Implementation;Drug usage;Effectiveness;effectiveness evaluation;electronic medical record system;Equity;Event;Event History Analysis;Evidence based treatment;experience;follow-up;Health;Health Services;heroin use;Homelessness;Homicide;hospital utilization;Hospitalization;illicit drug use;implementation evaluation;implementation framework;implementation process;Imprisonment;improved;improved outcome;Individual;informant;innovation;Intervention;Interview;Justice;Knowledge;learning strategy;Link;Lived experience;longitudinal analysis;Machine Learning;Maps;Measures;Medicaid;Medical;medication for opioid use disorder;Methods;Modality;Modeling;mortality;Natural experiment;New Jersey;Opioid;opioid epidemic;opioid use disorder;Outcome;Outcome Measure;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;Participant;participant interview;Pattern;peer;Persons;Policies;Policy Maker;Population;Population Intervention;Populations at Risk;prescription opioid;Prevention strategy;Prisoner;Prisons;Process;programs;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recidivism;Recording of previous events;Recovery;Relapse;Research;Rights;Role;Services;Subgroup;substance use;Substance Use Disorder;success;Suicide;Surveys;System;telehealth;Time;Translations;treatment program;Universities;uptake;Vulnerable Populations

PROJECT_TITLE: Improving Outcomes and Equity for Released Prisoners with SUD: Trajectories of Participation in Pre-Release and Post-Release MOUD, Peer Navigation, and Outcomes

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Social information processing is essential for social learning, memory and decision-making, which are social cognitive behaviors impaired in several neuropsychiatric disorders. Dissociating the neurmodulatory, circuit, and population coding mechanisms of two social characteristics will reveal general principles underlying social information processing. As no unified understanding of circuit and population coding of social information exist, results from this proposal have the potential to transform our current understanding of social cognition.

PI_NAMEs: WU, XIAOTING  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TITLE: Neural Mechanisms of Social Information Processing

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-G (01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

PHR: PROJECT NARRATIVE Dysfunction in how the brain makes decisions underlies virtually all psychiatric disorders. Here, we seek to leverage innovative approaches in rodent neuroeconomics in combination with new in vivo imaging technologies to determine the neural basis of complex forms of cognition – including counterfactual thinking, or the ability to represent consequences of unselected actions. This work will uncover how neurons integrate hypothetical information and how such processes influence future behavior, providing translational insights into how novel treatments for mental illnesses could be tailored to circuit-specific computational processes.

PI_NAMEs: SWEIS, BRIAN MUSA (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, FERNANDO R

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Animals;Axon;Behavior;Behavioral;Binding;Biological;Brain;Calcium;Categories;Cell Nucleus;Cells;Cognition;Cognitive;cognitive function;Color;Complex;cost;Cues;Data;Decision Making;Diagnostic;disease classification;Dissection;Economics;Emotions;Engineering;experience;Fiber;Functional disorder;Future;Genetic;Goals;Hippocampus;Human;Image;Imaging Device;Imaging technology;improved;in vivo;in vivo imaging;innovation;insight;Knowledge;Label;Learning;Link;Measurable;Measures;Mental Depression;Mental disorders;Methodology;model organism;Modeling;Monkeys;Mood Disorders;motivated behavior;Motivation;Mus;National Institute of Mental Health;neural;neuroeconomics;Neurons;Neurosciences;novel;Nucleus Accumbens;open source;operation;optogenetics;Outcome;Output;Pattern;Perception;Physiology;Play;Population;Predictive Value;Process;Property;Pruritus;Psychological reinforcement;Public Health;Reaction;Recording of previous events;Regrets;Rewards;Rodent;Role;rumination;Signal Transduction;Strategic Planning;Structure;Synapses;Technology;Testing;theories;Thinking;tool;Tracer;Translating;Translations;virtual;Work

PROJECT_TITLE: Neuroeconomic mechanisms of counterfactual thinking


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Skin Cancer;Telehealth

ORG_CITY: CHICAGO

PHR: PROJECT NARRATIVE Despite having an increased risk of developing new melanomas, melanoma survivors often do not engage in adequate sun protection, and the best set of interventions to help improve sun protection is not yet known. Given the promise of technology, in this project, we refine and test a mobile health intervention system that captures real-time sun exposure adjusted for self- reported sun protection use during outdoor activities and delivers up to 5 additional intervention components. This study will determine which intervention components are feasible, acceptable, and demonstrate preliminary efficacy in decreasing unprotected sun exposure..

PI_NAMEs: ALSHURAFA, NABIL  (contact);STUMP, TAMMY

PROGRAM_OFFICER_NAME: PERNA, FRANK

PROJECT_TERMS: Accelerometer;acceptability and feasibility;actigraphy;Adult;Algorithms;Behavior;Body part;burden of illness;Caregivers;Clinical Trials;design;Development;Diagnosis;Engineering;Evaluation;evidence base;experience;experimental study;Face;feasibility testing;Feedback;Foundations;Future;Health;health disparity;Health Policy;Health Technology;improved;Individual;Industry;innovation;Intervention;intervention refinement;iterative design;Knowledge;Life Style;Measures;Melanoma;Melanoma patient;Method Acceptability;Methodology;mHealth;mhealth interventions;moderate-to-vigorous physical activity;Monitor;multiphase optimization strategy;Participant;Patient Representative;Patient Self-Report;Patients;Phase;pilot test;Population;Preparation;Procedures;Radiation Dose Unit;Radiometry;Randomized;Recommendation;recruit;Recurrence;Reporting;Research;retention rate;Risk;sensor;Site;Skin Cancer;Source;Sun Exposure;sun protection;Sunburn;Sunscreening Agents;Surveys;Survivors;System;Technology;Testing;the sun;therapy development;Time;tool;Ultraviolet Rays;usability;user centered design;UV Radiation Exposure;Weather;Work

PROJECT_TITLE: SESAME: Sun Exposure and Activities after Skin CAncer: Optimization of Mhealth IntErventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE  This study aligns with NIMH strategic priorities and will strengthen the public health impact of NIMH- supported research by leveraging low-cost technology to improve the accessibility, efficiency, and scalability of evidence-based suicide prevention interventions for youth in Colombia. Study aims will investigate the innovative use of technology-assisted methods to reduce suicide risk and promote mental health among youth within the education sector. Study results have the potential to galvanize political will and improve adoption and sustainability of evidence-based, suicide prevention interventions within the education sector as well as in other alternative delivery settings able to reach vulnerable youth in LMICs and other low resource regions.

PI_NAMEs: DESROSIERS, ALETHEA  (contact);GOMEZ, CARLOS ;OSPINA PINILLOS, LAURA

PROJECT_TERMS: Address;Administrator;Adolescent;Adolescent and Young Adult;Adoption;Affect;aged;Anxiety;barrier to care;behavioral health;Caregivers;Cause of Death;Child;Colombia;Colombian;Communities;Conflict (Psychology);cost;Counseling;Country;COVID-19 pandemic;dashboard;Data;Data Science;design;digital;digital platform;digital tool;Education;effectiveness/implementation trial;Elements;Ensure;Evaluation;evidence base;Evidence based intervention;Exhibits;Exploration, Preparation, Implementation, and Sustainment;Feedback;Feeling suicidal;follow-up;gaps in access;health care delivery;Health Personnel;Health Professional;Health Sciences;health training;Hybrids;implementation barriers;implementation facilitators;implementation science;implementation/effectiveness;improved;Individual;innovation;Institution;Intervention;Link;low and middle-income countries;Mental Depression;Mental Health;mental health policy;Mental health promotion;Mental Health Services;Methods;mHealth;model building;Modeling;mood symptom;Moods;multidisciplinary;National Institute of Mental Health;Needs Assessment;Persons;Phase;Pilot Projects;pilot trial;Politics;Population;post intervention;Preparation;Prevalence;Prevention;preventive intervention;Process;programs;promote resilience;prototype;psychoeducation;psychosocial development;Public Health;reducing suicide;Reporting;Research;research and development;Research Support;Resource-limited setting;Risk Assessment;Risk Factors;Safety;Schools;screening;Secondary Schools;self help;Services;skill acquisition;skills;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;support tools;tailored messaging;teacher;Teacher Professional Development;Technology;Testing;tool;tool development;Training Programs;Trauma;trial design;Universities;usability;user centered design;violence exposure;Youth

PROJECT_TITLE: Harnessing culturally-appropriate, technology-assisted methods to advance suicide prevention among youth in Colombian school settings


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative We have discovered that the orphan nuclear receptor TLX can be targeted with small synthetic ligands. Such compounds may have the ability to enhance adult hippocampal neurogenesis, improve cognitive function and thus offer novel therapies for treatment of dementias including Alzheimer's disease among others. Here, we focus on developing, refining, and validation of TLX assays for the purposes of performing a screen for novel TLX ligands that can be used as points to initiate optimization efforts to develop TLX agonists towards potential clinical evaluation for treatment of diseases where cognitive function is impaired.

PI_NAMEs: BURRIS, THOMAS P (contact)

PROJECT_TERMS: abeta deposition;absorption;Address;Adult;Affinity;Agonist;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;American;Amyloid beta-Protein;Area;assay development;Automation;Biochemical;Biological;Biological Assay;Biology;Brain;Brain region;Cause of Death;Cells;Characteristics;Chemicals;Clinical;Clinical Research;cognitive function;Computer Analysis;cost;Cytoskeletal Proteins;Data;Data Analyses;Dementia;design;Development;Disease;Diversity Library;drug discovery;Drug Kinetics;Excretory function;extracellular;Frontotemporal Dementia;Future;Genetic;Goals;Grant;high throughput screening;Hippocampus;human old age (65+);hyperphosphorylated tau;Impaired cognition;Impairment;improved;In Vitro;in vitro Assay;in vivo evaluation;Individual;Informatics;Knowledge;large scale data;lead optimization;Learning;Lewy Body Dementia;Libraries;Ligands;Measurement;Memory;Memory Loss;Metabolism;miniaturize;mixed dementia;Modeling;mouse model;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neurogenesis;neuroinflammation;Neuromuscular Diseases;neuron loss;Neurons;novel;novel therapeutics;Nuclear Orphan Receptor;Nuclear Receptors;overexpression;Pathology;Pathway interactions;Patients;Permeability;Pharmaceutical Chemistry;pharmacologic;Phase;Phenotype;Play;Preparation;Production;Property;Publishing;Research;research clinical testing;Retinoic Acid Receptor;Role;scaffold;screening;Series;small molecule libraries;Solubility;Specificity;Structure;Structure-Activity Relationship;Surface;Testing;Therapeutic;Therapeutic Agents;therapeutic development;United States National Institutes of Health;Validation;Vascular Dementia

PROJECT_TITLE: Screening for Nuclear Receptor TLX ligands


PHR: There is a need to identify the causes of the most severe form of male infertility, non-obstructive azoospermia (NOA), where there is spermatogenic failure resulting in an ejaculate with no sperm. NOA men have an increased risk of serious diseases, such as cancer, when compared with fertile men or men with sperm in their ejaculates. However, the link between their infertility and their increased disease risk has remained elusive.

PI_NAMEs: LAMB, DOLORES JEAN (contact)

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;Age;Alkylating Agents;bile duct;Breast;Canada;cancer diagnosis;cancer risk;cancer type;Chromosome abnormality;Clinic;cohort;Colon;Consultations;Couples;Data;Databases;Defect;Development;Diagnosis;Disease;disorder risk;DNA;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Gene;Double Strand Break Repair;Early Intervention;Ejaculation;Endometrial;Epigenetic Process;Etiology;Evaluation;Exhibits;Exposure to;Failure;Fertilization in Vitro;Gene Deletion;Gene Expression;Gene Mutation;gene repair;General Population;Genes;Genetic;Genetic Predisposition to Disease;Genomic Instability;Genomics;Health;Hematology;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Homologous Gene;homologous recombination;homologous recombination deficiency;Human;Immune System Diseases;Impairment;improved;Incidence;Infertility;Injections;insight;Institution;Intracytoplasmic Sperm Injections;Investigation;Kidney;Knowledge;Laboratories;Link;male;Male Infertility;Malignant neoplasm of brain;Malignant Neoplasms;Medical;medical schools;Meiosis;men;Mismatch Repair;Mismatch Repair Deficiency;Molecular;mouse model;Mutation;Nature;neoplasm registry;Organ;Outcome;Ovarian;Pancreas;Pathology;Patients;Play;Premature Ovarian Failure;Production;Prostate;Proteins;Publishing;Recording of previous events;Registries;Reproductive Medicine;response;Risk;Seminal fluid;Small Intestines;sperm cell;Sperm Count Procedure;Stomach;Syndrome;Testing;Testis;Thyroid Gland;Time;Treatment Cost;Urinary tract;urologic;Uterus;Variant;virtual;Work;young man

PROJECT_TITLE: DNA Repair Deficiencies in Infertile Men and Cancer Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-J (55)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative  Hepatocellular carcinoma (HCC) is a major human malignancy and is largely incurable. In this project, we will define the molecular mechanisms of resistance to cabozantinib therapy in HCC. The results from this project will provide a mechanistic basis for therapeutic intervention to overcome cabozantinib in HCC patients.

PI_NAMEs: QIU, WEI  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Affect;Apoptotic;BAY 54-9085;bevacizumab;cancer cell;Cells;Clinical;clinical efficacy;Data;Development;Drug resistance;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;FDA approved;Goals;Growth Factor;Human;improved;inhibitor;insight;ipilimumab;KDR gene;kinase inhibitor;Light;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;medullary thyroid carcinoma;Modeling;Molecular;molecular targeted therapies;neoplastic cell;neutralizing antibody;Nivolumab;novel;novel therapeutic intervention;novel therapeutics;overexpression;Patients;pembrolizumab;Phosphotransferases;Placebos;Primary carcinoma of the liver cells;Progression-Free Survivals;Recombinants;Renal Cell Carcinoma;Research;Resistance;Resistance development;resistance mechanism;response;Serine Protease;SPINK1 gene;success;Survival Rate;Systemic Therapy;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;tumor;tumor growth;Xenograft Model

PROJECT_TITLE: Elucidating molecular mechanisms of cabozantinib resistance in liver cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-F (J2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Kidney Disease

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

PHR: PROJECT NARRATIVE Aeorobic organisms are highly susceptible to fluctuations in oxygen levels, which is manifested in many disease states. This project aims to investigate an endogenous signaling pathway that reduces metabolic rate and enable cells to withstand longer periods without oxygen. The ability to manipulate these pathways in human cells has significant therapeutic implications for the prevention of hypoxic injury that occurs in many disease states (e.g. pulmonary vascular disease, acute kidney injury, diabetes and neurodegenerative diseases).

PI_NAMEs: BREWSTER, RACHEL MELISSA (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adaptor Signaling Protein;Adenosine Triphosphate;Aerobic;Age;American;Anoxia;Area;Baltimore;Binding;Biology;career preparation;Cause of Death;Cell Death;Cell Hypoxia;Cell membrane;Cell Membrane Permeability;Cell Respiration;Cells;Cessation of life;Chronic Kidney Failure;County;Development;Diabetes Mellitus;Disease;doctoral student;Down-Regulation;Edema;Electron Transport;Embryo;Endosomes;Environment;Event;evidence base;experimental study;Exposure to;Faculty;Genes;Goals;Health;Human;Hypoxia;improved;In Situ;Injury;Institutionalization;Ion Transport;Ions;Kidney;kidney cell;knowledge translation;Label;Laboratories;Life;Literature;Maryland;Mediating;Mediator;member;Metabolic;metabolic rate;model organism;Modeling;mutant;N-Myc Protein;Na(+)-K(+)-Exchanging ATPase;Neurodegenerative Disorders;Normal Range;novel;Organism;Oxygen;Pathology;Pathway interactions;Positioning Attribute;Post-Translational Protein Processing;Predisposition;preservation;prevent;Prevention;Process;Production;programs;protein transport;Proteins;Publications;Publishing;pulmonary vascular disorder;Pump;Reactive Oxygen Species;recruit;Renal function;Research;Research Training;response;Role;Services;Sickle Cell Anemia;Signal Pathway;Signal Transduction;Societies;Sodium Azide;STEM field;Stroke;Students;symposium;Testing;Therapeutic;trafficking;Training;Training Programs;Transferable Skills;translational potential;Underrepresented Populations;Underrepresented Students;underserved community;Universities;Vesicle;Woman;Work;Zebrafish

PROJECT_TITLE: NDRGs as mediators of hypoxia adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-G (56)]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Mitochondria serve as the powerhouses to sustain their continuous beating of heart muscle cells, and their dysfunction has been linked to various cardiac and systemic disorders. This investigation aims to elucidate the significance of Cullin 3-RING ubiquitin ligase in monitoring and maintaining mitochondrial health under normal and stressed conditions in the heart. Completion of the proposed studies not only offers potential therapeutic targets for heart failure but also provides valuable fundamental insights into biological processes with broad applicability.

PI_NAMEs: SU, HUABO  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Ablation;Adenoviruses;Adult;Affect;autism spectrum disorder;Autophagocytosis;Biochemical;Biogenesis;Biological Assay;Biological Process;Biotinylation;Blood Vessels;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiomyopathies;cardioprotection;Cell Physiology;Complex;Cullin Proteins;cullin-3;Development;Disease;Down-Regulation;Embryo;Epilepsy;experimental study;factor A;familial hyperkalemic hypertension;Family;Functional disorder;Genes;Genetic Transcription;Genetically Engineered Mouse;global health;Goals;Health;Heart;heart damage;Heart failure;heart function;Homeostasis;Human;human disease;Hypertension;Hypertrophy;Impairment;improved;in silico;insight;Investigation;Kidney;Knock-in Mouse;Knockout Mice;Knowledge;Link;Mediating;Mitochondria;Mitochondrial DNA;Molecular;Monitor;Morbidity - disease rate;mortality;mouse model;mtTF1 transcription factor;Mus;mutant;Mutation;Myocardial dysfunction;novel;overexpression;Parkin;Pathologic;Perinatal;Play;Population;postnatal;pressure;prevent;Process;Production;protein degradation;Proteins;Proteomics;RBX1 gene;receptor;recruit;Regulation;Reporter;Research;Respiration;Role;Satellite Viruses;scaffold;Series;Signal Transduction;Sodium;Stress;System;Tamoxifen;Testing;therapeutic target;transcription factor;Transgenic Mice;tumor growth;ubiquitin ligase;Ubiquitin Like Proteins;Ubiquitination;Up-Regulation

PROJECT_TITLE: Elucidating the role of Cullin 3 in the heart

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Public Health Relevance Despite an overall lower tobacco exposure, African-Americans have the highest burden of lung cancer in the U.S. of any racial/ethnic group. Findings from this project could contribute significantly to our understanding of the genetic susceptibility of lung cancer among African-Americans. This research will help explain why lung cancer affects African-Americans more often than European Americans and will potentially lead to new and improved modes of diagnosis and prevention for patients with lung cancer among African-Americans.

PI_NAMEs: LIU, YANHONG  (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Admixture;Affect;African;African American population;African ancestry;American;ancestry analysis;Ashkenazim;Asian ancestry;biobank;Cancer Etiology;Cancer Family;Cancer Patient;cancer risk;causal variant;Collection;comparative;Complex;Data;Data Analyses;Data Collection;Databases;Death Rate;Development;Diagnosis;disease-causing mutation;Disparity;DNA Damage;early onset;East Asian;ethnic diversity;Ethnic Population;European;exome;exome sequencing;Family;Family history of;Family member;First Degree Relative;follow-up;Frequencies;Future;Gene Frequency;General Population;Genes;Genetic;genetic analysis;genetic architecture;genetic association;genetic epidemiology;genetic linkage analysis;Genetic Predisposition to Disease;Genetic study;Genetic Variation;genome sequencing;genome wide association study;genome-wide;genome-wide analysis;Genotype;Germ Lines;health disparity;Heritability;high risk;Immune response;improved;Incidence;Individual;insertion/deletion mutation;internal control;lung basal segment;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Meta-Analysis;Minor;Minority Groups;mortality;novel;Participant;Pathogenicity;Patients;Population;Population Control;Prevention;public health relevance;Race;racial difference;racial diversity;racial population;rare variant;Research;Risk Assessment;Risk Factors;risk variant;Role;Sampling;segregation;Single Nucleotide Polymorphism;smoking exposure;targeted sequencing;tobacco exposure;Tobacco smoking behavior;trait;trend;Variant;whole genome

PROJECT_TITLE: Identifying germline pathogenic variants in familial lung cancer among African-Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (J1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE This project will develop a novel microfluidic approach to elucidate the effects of soluble factor gradients, individually and in controlled combinations, on zonated functions in primary liver cells from rodents and humans towards determining species-specific effects. Ultimately, our novel devices can be used to investigate the mechanisms underlying liver zonation, chemical-induced zonated hepatotoxicity, and how zonation is perturbed in liver diseases, such as non-alcoholic fatty liver disease and hepatocellular carcinoma.

PI_NAMEs: KHETANI, SALMAN R (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 3-Dimensional;Affect;Animals;beta catenin;Birth;Cell Culture Techniques;Cell secretion;cell type;Cells;Chemicals;Communities;Complex;Cues;Cultured Cells;Custom;Data;design;Devices;Discontinuous Capillary;Disease;drug development;drug induced liver injury;Endothelial Cells;Engineering;Environment;Exhibits;Extracellular Matrix;Fatty Acids;Fetal Liver;Fructose;functional decline;functional outcomes;Gel;Gene Expression;gene function;Generations;Genes;Glass;Glucagon;Glucose;Hepatic;Hepatic Stellate Cell;Hepatocyte;Hepatotoxicity;Hormonal;Hormones;Human;Image;In Vitro;in vivo;Individual;Insulin;intercellular communication;Investigation;Kupffer Cells;Literature;Liver;Liver diseases;liver function;liver injury;meter;Microfluidic Microchips;Microfluidics;Modeling;Molecular Probes;mRNA Differential Displays;non-alcoholic fatty liver disease;novel;Nutrient;Nutritional;Oxygen;Pathway interactions;Perfusion;Phase;Phenotype;Physiological;Primary carcinoma of the liver cells;Publishing;Rattus;Regenerative Medicine;Regulation;Reproducibility;Resolution;Resources;response;Rodent;Role;spheroids;Stimulus;synergism;Testing;Tissues;tool;transcription factor;transcriptome sequencing;Transformed Cell Line

PROJECT_TITLE: Engineered culture platforms to uncover synergies between microenvironmental cues in modulating liver zonation

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]