NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Rift Valley fever virus is a mosquito-borne pathogen associated with large outbreaks of severe veterinary and human disease throughout Africa and the Arabian Peninsula. Understanding the transmission pathways that result in this severe viral disease is critical for creating effective prevention and control strategies.

PI_NAMEs: MADUT, DENG BUOK (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: abortion;Aedes;Africa;African;Age;Agriculture;Animals;Arboviruses;Award;Behavior;Biological;career;career development;Cattle;Cell Culture Techniques;Characteristics;Circulation;Clinical Research;Collaborations;Culicidae;Dairying;Data;density;Detection;Development;Disease;Disease Outbreaks;disease transmission;Dryness;Ecology;Elements;Environment;enzootic;Epidemic;epidemic potential;Epidemiology;epizootic;experience;Farm;Fever;Funding;Generations;Goals;Grasslands;Health;Household;Human;human disease;Immunoglobulin G;Immunoglobulin M;Infection;infectious disease model;Infectious Diseases Research;insight;Institution;International;Interruption;Intervention;K-Series Research Career Programs;Livestock;Maintenance;mathematical model;Medical center;Mentors;Milk;milk production;Modeling;mosquito-borne pathogen;Nature;nucleic acid detection;Nucleic Acids;pasteurization;pathogen;Pathway interactions;Pattern;peri-urban;permissiveness;Physicians;Population;Predisposition;Prevalence;Prevention;Productivity;programs;Recurrence;Regression Analysis;Reporting;Research;Research Activity;research and development;Research Personnel;Resources;Rift Valley Fever;Rift Valley fever virus;Risk;Risk Factors;Role;Rural;rural setting;Sampling;Scientist;Seasons;Serology;seropositive;Seroprevalences;skills;sociodemographics;Structure;surveillance study;Surveys;Tanzania;Testing;Time;transmission process;United States National Institutes of Health;Universities;urban area;urban setting;Variant;Vertical Transmission;Viral;viral transmission;Virus;Virus Diseases;Work;working group;Zoonoses

PROJECT_TITLE: Transmission dynamics and epidemiology of Rift Valley fever virus in northern Tanzania

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Physical Activity;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Chemotherapy-related cognitive decline (CRCD) is a common and consequential complication of cancer treatment, yet no standard of care exists to prevent or treat CRCD. This three-arm randomized controlled trial will examine the feasibility, acceptability, and preliminary efficacy of memantine and exercise to mitigate cognitive decline in patients with breast cancer undergoing chemotherapy. This study will contribute several insights important to improving cognitive outcomes in patients with cancer, including: feasibility of multicomponent medication and behavioral intervention trials for CRCD; preliminary efficacy of combined memantine and exercise, as well as of memantine alone, for cognitive decline and underlying mechanisms of CRCD; and characterization of the impact of frailty on treatment-related changes in cognitive function and CRCD biomarkers.

PI_NAMEs: NAKAMURA, ZEV  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Aerobic Exercise;age-related disease;Aging;aging mechanism;anti-cancer research;arm;Attention;Award;Behavior Therapy;Behavioral;behavioral clinical trial;Biological;Biological Markers;Bone Marrow Transplantation;Brain-Derived Neurotrophic Factor;Breast Cancer Patient;cancer complication;Cancer Patient;cancer therapy;carcinogenesis;career;chemotherapy;Chemotherapy-Oncologic Procedure;Clinic;Clinical;clinical training;clinical trial analysis;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;Cognitive Therapy;Combination Medication;Complex;COVID-19;cytokine;Data;design;Dose;Education;effective intervention;efficacy testing;Environment;executive function;Exercise;exercise program;exercise regimen;Exhibits;experience;Fatigue;follow-up;frailty;Functional disorder;fundamental research;Future;Goals;Heel;Impaired cognition;Impairment;improved;indexing;Inflammation;Inflammatory;Infrastructure;insight;inter-individual variation;Intervention;Intervention Trial;K-Series Research Career Programs;Lead;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Medical;medical specialties;Memantine;Memory;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentorship;Moods;multidisciplinary;neuro-oncology;neuropsychiatric symptom;Neuropsychology;North Carolina;Oncology;Outcome;Participant;participant enrollment;Pathway interactions;Patient Outcomes Assessments;Patients;Personal Satisfaction;Pharmaceutical Preparations;Phenotype;Physical Exercise;Physical Function;Physiological;pilot trial;Placebos;Population;Positioning Attribute;post intervention;Pre-Clinical Model;prevent;primary endpoint;primary outcome;Property;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Personnel;Research Training;Resources;retention rate;Risk;Risk Factors;Safety;satisfaction;secondary outcome;standard measure;standard of care;strength training;System;Testing;Training;transplantation therapy;Universities

PROJECT_TITLE: Memantine and Exercise for Chemotherapy-Related Cognitive Decline in Patients with Breast Cancer

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Melanoma treatments have hit a ‘ceiling’, requiring further therapeutic strategies to increase survival rates. Our studies have demonstrated that BRAFV600E regulates PHGDH enzyme expression to establish a metabolic vulnerability of melanoma cells where BRAF inhibition combined with dietary Serine restriction deprives cells of sufficient Serine. We will preclinically test this strategy using both genetic and pharmacologic approaches in melanoma mouse models.

PI_NAMEs: KARRETH, FLORIAN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Address;Affect;Alleles;Attenuated;BRAF gene;cancer cell;Cell Death;Cells;checkpoint therapy;Clinic;Clinical;Colon Carcinoma;Combined Modality Therapy;Data;dietary;Drops;Drug resistance;efficacy evaluation;Enzymes;Excision;experimental study;extracellular;FDA approved;FRAP1 gene;Genetic;genetic approach;Genetic Engineering;Goals;Growth;Human;immune checkpoint blockade;Immune checkpoint inhibitor;Immunotherapy;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Isogenic transplantation;Maintenance;MAP Kinase Gene;Mediating;MEK inhibition;Melanoma;Melanoma Cell;Metabolic;Metabolism;Metastatic Melanoma;Modeling;mouse model;mTOR inhibition;mutant;Neoplasm Metastasis;novel;novel therapeutic intervention;Oncogenic;Pathway interactions;patient subsets;Patient-Focused Outcomes;Persons;Pharmaceutical Preparations;pharmacologic;Phosphoglycerate dehydrogenase;Play;Positioning Attribute;pre-clinical;pre-clinical assessment;Preclinical Testing;Proliferating;Protein Isoforms;Recurrent disease;resistance mechanism;Role;Series;Serine;Signal Transduction;Site;small molecule inhibitor;standard of care;Starvation;Survival Rate;synergism;systemic toxicity;targeted treatment;Testing;Therapeutic;Toxic effect;Translating;Treatment Protocols;tumor;tumor growth;tumor microenvironment

PROJECT_TITLE: Targeting a PHGDH metabolic vulnerability in melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-5 (J1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Transplantation

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Over 30-50% of autologous vein grafts (VG) used to treat coronary artery disease and occlusive peripheral arterial disease fail within 5-10 years of surgery due to intimal hyperplasia (IH). To address this unmet clinical need, we propose to bioengineer VG with the potent atheroprotective molecule A20, using advanced AAV and circular RNA gene therapy (GT) platforms. This first-in-class therapy that can be directly implemented on the operating table will be tested in two relevant animal models of VG failure, in prelude for clinical translation.

PI_NAMEs: BHASIN, MANOJ ;FERRAN, CHRISTIANE  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Acceleration;Accounting;Address;Angiography;Animal Model;Animals;Anti-Inflammatory Agents;Apoptosis;Apoptotic;Area;Articulation;atheroprotective;Atherosclerosis;Autologous;Biology;Biomedical Engineering;Blood Vessels;Bypass;Canis familiaris;Cause of Death;cell motility;Cell Proliferation;Cells;cephalic vein;Cessation of life;circular RNA;clinic ready;Clinical;clinical application;clinical implementation;clinical translation;Collaborations;Common carotid artery;Common Femoral Artery;Complex;Coronary Arteriosclerosis;Coronary Artery Bypass;Data;Dependovirus;Development;Effectiveness;efficacy study;Endothelial Cells;Endothelium;Engineering;Ensure;Evaluation;ex vivo perfusion;Exhibits;Exploratory/Developmental Grant;Exposure to;external jugular vein;Extracellular Matrix;Failure;Funding;gene regulatory network;gene therapy;Gene Transduction Agent;Genes;Genetic Transcription;Government;graft failure;Harvest;hemodynamics;Hour;Human;human disease;Human Engineering;Hybrids;Hyperplasia;Image;Immune;implantation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Injury;Investigational Drugs;Laboratories;Lead;Lesion;Lower Extremity;Macrophage;Maps;Medical;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;new technology;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patients;Perfusion;Peripheral arterial disease;Persons;Phenotype;Pilot Projects;pre-clinical;prevent;Procedures;Proliferating;Property;protein expression;Proteins;Proteomics;recruit;Regimen;Research;Resistance;response;revascularization;revascularization surgery;Risk Factors;Safety;Saphenous Vein;Scheme;Smooth Muscle Myocytes;Stenosis;System;Technology;Temperature;Testing;Therapeutic;Therapeutic Agents;Therapeutic Studies;Thrombosis;thrombotic;Time;tissue culture;Tissues;TNF gene;Toxic effect;transcriptome;transcriptomics;transgene expression;Transgenes;Trauma;Tropism;Vascular Diseases;vascular inflammation;Vascular remodeling;vascular smooth muscle cell migration;vector;Vein graft;Veins;viral RNA;virulence gene;Weight-Bearing state;Western Blotting;Western World

PROJECT_TITLE: Vascular-targeted Atheroprotective Gene therapies to Prevent Vein Graft Failure

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative/Public health relevance: Improved understanding of the mechanisms that promote regulatory T cell (Treg) survival and function under inflammatory conditions is critical to design highly efficient clinical Treg enhancing therapies to treat kidney transplant rejection and restore immune homeostasis in patients with autoimmune diseases.

PI_NAMEs: SKARTSIS, NIKOLAOS  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Agonist;Alloantigen;Animal Model;Antioxidants;Applications Grants;Autoantigens;Autoimmune Diseases;Award;Basic Science;Binding;Bioinformatics;Biological Products;career;CD28 gene;cdc Genes;Cell Cycle;Cell Lineage;Cell Physiology;Cell Proliferation;Cell Survival;Cell Therapy;Cells;Cellular biology;Cellular Metabolic Process;Chromatin Remodeling Factor;Clinic;Clinical;Clinical Sciences;Clinical Trials;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;college;CRISPR screen;CRISPR/Cas technology;cytokine;Data;design;Diagnosis;disease model;early phase clinical trial;effector T cell;Ensure;Epigenetic Process;Equilibrium;fitness;FOXP3 gene;functional genomics;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Graft Rejection;Grant;Growth;healing;Homeostasis;Human;Immune;Immune response;Immune system;Immune Tolerance;Immunobiology;Immunologics;Immunosuppressive Agents;Immunotherapeutic agent;improved;In Vitro;in vivo;Inflammation;Inflammatory;inflammatory milieu;Infusion procedures;innovation;Interleukin-2;Interleukin-6;Kidney Transplantation;Kinetics;Knowledge;Legal patent;Life;logarithm;manufacturing process;Mediating;Medicine;Mentors;Metabolic;Metabolic Control;metabolic fitness;metabolic profile;metabolomics;Mitochondria;mitochondrial metabolism;Modality;Molecular;multidisciplinary;multiple omics;Mus;neoplastic;next generation;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Organ Transplantation;Pathway interactions;Patients;Phenotype;pre-clinical;Pre-Clinical Model;Pre-Eclampsia;preservation;prevent;professor;programs;Proliferating;public health relevance;Receptors, Tumor Necrosis Factor, Type II;Regulatory T-Lymphocyte;Research;Research Personnel;response;Role;safety testing;Science;Signal Transduction;STAT3 gene;success;T cell therapy;T-Cell Activation;T-Cell Proliferation;Techniques;Therapeutic immunosuppression;tissue injury;Tissues;TNFRSF1B gene;tool;Training;transcription factor;Transcriptional Regulation;Translational Research;translational scientist;Transplant-Related Disorder;Transplantation;transplantation therapy;Virginia;Work

PROJECT_TITLE: Mechanisms of regulatory T cell adaptation to inflammation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE The goal of this application is to explore the development and feasibility of a brief, family-based adaptive intervention, via SMART design, for youth 10 to 14 years with suicidal and non-suicidal self-injurious behavior (SSIB) to increase community-based mental health (MH) care attendance and reduce SSIB risk post emergency department (ED) admission. The intervention will focus to increase understanding on youth MH literacy, MH communication, and MH engagement. Integrating an adaptive intervention via a SMART design in the ED could address subsequent barriers to youth obtaining appropriate level of community-based MH care and therefore reduce ED readmissions.

PI_NAMEs: CANCILLIERE, MARY KATHRYN MELONIO (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;adaptive intervention;Address;Admission activity;Adolescent;aged;barrier to care;Behavior;care seeking;career;Caregivers;Caring;Case Management;Cause of Death;certificate program;Child;child mental health service;Childhood;Communities;community based care;cost;Data;Dedications;Development;digital;digital health;digital technology;Disparity;Dose;Effectiveness;Emergency department visit;Emergency research;Emergency Situation;Ensure;Ethnic Origin;experience;Family;Family health status;Frequencies;Gender;Goals;health communication;health knowledge;health literacy;Health system;Heterogeneity;hospital readmission;implementation evaluation;improved;improved outcome;Individual;innovation;Intensive Care;interest;Intervention;Lesbian Gay Bisexual Transgender Queer;Literature;Measures;Mental disorders;Mental Health;Mental Health Services;Mental Tests;Mentored Patient-Oriented Research Career Development Award;Methods;Minority;Modeling;Motivation;National Institute of Mental Health;Patients;pediatric emergency;personalized approach;Population;Population Heterogeneity;preadolescence;Prevalence;Prevention strategy;primary outcome;Procedures;Protocols documentation;psychiatric emergency;psychosocial;psychosocial development;Public Health;Race;Randomized;Recommendation;reducing suicide;Research;Research Activity;Research Personnel;Resources;response;Risk;Risk Behaviors;Secure;Self-Injurious Behavior;Sequential Multiple Assignment Randomized Trial;Service delivery model;Services;Severities;social culture;Statistical Data Interpretation;Strategic Planning;suicidal;suicidal risk;Suicide prevention;suicide rate;Symptoms;System;systemic barrier;technology development;Testing;Therapeutic;therapy development;Training Activity;treatment strategy;trial design;Universities;usability;Waiting Lists;Youth

PROJECT_TITLE: An Adaptive Intervention to Increase Engagement to Community-based Care After an ED Admission: For Youth Aged 10 to 14 at Risk for Suicide and Self-injurious Behavior

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

ORG_CITY: NEW YORK

ORG_DEPT: PHARMACOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE  The ability to dynamically switch cell states enables cancer cells to adapt to environmental and therapeutic challenges, however, the molecular mechanisms that cancer cells employ to maintain or switch states have not been fully characterized. This proposal aims to dissect the cell-intrinsic and extrinsic mechanisms underlying lung cancer cell plasticity by leveraging a newly developed single-cell lineage tracing technology. A comprehensive understanding of these mechanisms will reveal key gene networks that regulate tumor evolution, and could potentially inform rational therapeutic approaches.

PI_NAMEs: YANG, DIAN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: 3-Dimensional;acquired drug resistance;Address;Advisory Committees;Cancer Biology;cancer cell;Cancer cell line;cancer therapy;candidate identification;career development;Cell Lineage;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;computer framework;CRISPR/Cas technology;Data;Development;Disease Progression;Distant;Drug resistance;Environment;Epithelial Cells;Evaluation;Evolution;Exhibits;fitness;Frequencies;gene network;Genes;Genetic;Genetic Transcription;Goals;Grant;Heterogeneity;HNF4A gene;human cancer mouse model;Immune Evasion;Immune system;Immunotherapeutic agent;in vivo;inhibitor;innovation;insight;Institution;Invaded;Knock-out;Lead;Ligands;Lung Adenocarcinoma;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mentorship;Methods;Modeling;Molecular;mouse model;Mus;Neighborhoods;Neoplasm Metastasis;novel therapeutic intervention;Oncogene Activation;Other Genetics;pharmacologic;Phenotype;Phylogenetic Analysis;Positioning Attribute;Postdoctoral Fellow;progenitor;programs;receptor;Recording of previous events;Regulation;Reporting;Research;Research Ethics;Research Project Grants;Resistance development;Resolution;Resources;response;Role;Secure;Signal Induction;Signal Transduction;single cell genomics;Site;skills;spatial integration;Stromal Cells;System;Technology;Testing;Therapeutic;therapy resistant;Tissues;tool;Tracer;Training;Training Activity;transcriptome;transcriptomics;tumor;Tumor Expansion;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion

PROJECT_TITLE: Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (J1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: BINGHAMTON

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: NARRATIVE Aberrant biosynthesis of human Sonic hedgehog (Hh) proteins in adult tumors results in a pro- growth survival signal that can spur tumor cell proliferation, invasiveness and chemoresistance. Here we pursue the first small molecules to specifically block Hh protein autoprocessing, a key step in the biosynthesis of these oncogenic effector proteins. We hypothesize that the cell- permeable small molecules discovered here will show anti-cancer activity against human myeloma and colon cancer cells, which we will test experimentally to establish the groundwork for a new class of targeted anti-cancer therapeutics.

PI_NAMEs: CALLAHAN, BRIAN PATRICK (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Address;Adult;Anabolism;antagonist;anti-cancer;anti-cancer therapeutic;anticancer activity;antitumor effect;Apoptosis;Binding;Biological Assay;Bioluminescence;cancer cell;Cell Line;Cell Maintenance;Cell Membrane Permeability;Cell Proliferation;Cell secretion;Cells;Cellular Assay;Chemoresistance;Cholesterol;Circadian Rhythms;Clinical;Collaborations;Colon Carcinoma;Couples;deprivation;Drosophila genus;Drug resistance;Drug Targeting;Embryonic Development;Enzymes;Erinaceidae;Event;Exhibits;extracellular;Goals;Growth;high risk;high throughput screening;Homologous Gene;Human;In Vitro;inhibitor;innovation;Left;Letters;Libraries;Ligands;Malignant Neoplasms;miniaturize;Molecular;Multiple Myeloma;National Center for Advancing Translational Sciences;neoplastic cell;novel;Oncogenic;Permeability;Pharmaceutical Preparations;Photoaffinity Labels;Positioning Attribute;preclinical evaluation;Protein Family;Proteins;Reaction;receptor;Reporter;Reporting;screening;SHH gene;Signal Transduction;small molecule;smoothened signaling pathway;Specificity;stem cells;success;synergism;System;targeted cancer therapy;Testing;Therapeutic;Translations;tumor;tumorigenic;United States National Institutes of Health;Universities;validation studies;Work

PROJECT_TITLE: Discovery and anti-tumor activity of the first antagonists targeting human Sonic Hedgehog autoprocessing

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (J1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Microbiome;Nutrition;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Eosinophilic granulomatosis with polyangiitis (EGPA, formerly known as Churg Strauss syndrome) is a rare, serious disease of blood vessel and internal organ inflammation associated with high levels of immune cells called eosinophils. Patients who have EPGA affecting the intestine tend to do worse, underscoring a need to better understand eosinophils in the intestine. We discovered that signals derived from nutrients regulate small intestine eosinophils during normal conditions, and propose to understand how these signals work, to figure out the impacts of certain aspects of the microbiome, and to study small intestine eosinophils along with these factors in a mouse model of EGPA.

PI_NAMEs: KORN, LISA LENORE (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Abdominal Pain;Adoptive Transfer;Advisory Committees;Affect;Biology;Blood Vessels;Bromodeoxyuridine;career;career development;Cells;Churg-Strauss Syndrome;Clinical;Complex;cytokine;Cytoplasmic Granules;cytotoxic;Data;Death Rate;design;Diarrhea;Diet;dietary;dietary control;Dietary Proteins;Disease;Doctor of Philosophy;Environment;eosinophil;Eosinophilia;Etiology;experience;Exposure to;Fellowship;Flow Cytometry;Gastrointestinal Hemorrhage;Gastrointestinal tract structure;Gene Expression Profile;Germ-Free;Goals;granulocyte;gut microbiota;Hematological Disease;Homeostasis;Human;Immune;Immune response;Immune system;Immunobiology;Immunology;Inflammation;Inflammatory;Interleukin-5;intestinal villi;Intestines;Label;Lead;Macronutrients Nutrition;Measurement;Mediating;Medicine;Mentors;Mentorship;mepolizumab;Methods;microbial;microbiome;microbiota;Microscopy;Morphology;mouse model;Mucous Membrane;Mus;Nutrient;Organ;Patients;Perforation;Physicians;Physiologic pulse;Physiology;Population;Principal Investigator;Process;Prognosis;Proteins;Relapse;Research;Research Personnel;Research Training;residence;Residencies;Resources;Rheumatism;Rheumatology;Scientist;Series;Signal Transduction;Small Intestines;Stains;Surface;Testing;Time;Tissues;Training;Training Programs;transcriptome sequencing;Tretinoin;Universities;Vasculitis;Villus;Vitamin A;Work

PROJECT_TITLE: Understanding diet-microbiota interactions in small intestine eosinophil tissue residency during homeostasis and eosinophilic granulomatosis with polyangiitis (EGPA)

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention;Social Determinants of Health

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The overarching goal of this K01 Career Development Award is to foster Dr. Byoungjun Kim’s transition to independence as a social/spatial epidemiologist with expertise in examining neighborhood effects on chronic kidney disease (CKD). The proposed study will draw on quasi-experimental study design to investigate associations between co-occurring neighborhood conditions (e.g., social environments, food desert, walkability, and ambient pollutions) and CKD outcomes, leveraging electronic health record data from a national cohort of U.S. veterans. Findings from this work will contribute to the evidence base regarding nuanced causal mechanisms between various neighborhood exposures and CKD outcomes via its clinical causes and will shed light on potential place-based interventions to reduce health disparities in CKD.

PI_NAMEs: KIM, BYOUNGJUN  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Accounting;Address;Adult;Affect;Agriculture;Air;Alcohols;analytical method;Award;Biometry;Buffers;built environment;burden of illness;career;Caring;Censuses;Cessation of life;Characteristics;Chronic Kidney Failure;Clinical;clinical development;cohort;Community Developments;computable phenotypes;Data;Databases;design;Diabetes Mellitus;Disease Outcome;Disease Progression;disorder risk;Disparity;Disparity population;econometrics;Educational workshop;Electronic Health Record;Epidemiologist;Epidemiology;epidemiology study;Ethnic Origin;Etiology;evidence base;experience;flexibility;food desert;food environment;Fostering;Future;Geography;Glomerulonephritis;Goals;Green space;Hazardous Waste;Health;health disparity;health equity;Health Policy;Hypertension;Incidence;Individual;Integrated Health Care Systems;International Classification of Disease Codes;Intervention;Investments;Joints;K-Series Research Career Programs;Kidney Failure;Learning;Link;Literature;Measures;Mediating;Mediation;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Modeling;modifiable risk;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural experiment;neighborhood disadvantage;Neighborhoods;Nephrology;novel;obesity prevention;Outcome;Pathway interactions;Patients;Pattern;Persons;Pollution;Prevalence;Quasi-experiment;Race;Reduce health disparities;Research;Research Design;Residential Mobility;Restaurants;Retrospective cohort;Risk Factors;Risk Reduction;Role;Rural Community;Series;social;social disparities;Social Environment;social epidemiology;sociodemographics;Socioeconomic Status;spatial epidemiology;Strategic Planning;Structure;Supermarket;symposium;System;Time;tool;Training;Transportation;treatment group;United States Environmental Protection Agency;Urban Community;Urbanicity;Veterans;Veterans Health Administration;Wages;walkability;Work

PROJECT_TITLE: Neighborhood Characteristics and Chronic Kidney Disease Incidence/Progression: A Quasi-Experimental Study

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: CAMBRIDGE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Project Narrative The neurotransmitter dopamine (DA) is thought to play a central role in reward-based learning, but the precise nature of this role and how it may be implemented in neural circuits remain the subject of controversy. Taking a reductionist approach, this project leverages novel optical, electrophysiological, and machine learning tools to precisely identify the algorithmic and neural circuit basis of dopamine-driven learning in the striatum of behaving mice. By isolating and dissecting dopamine’s role in learning with unprecedented precision, this project has the potential to transform our understanding of diseases that involve the dysregulation of dopamine, including Parkinson’s disease, addiction, and mood disorders.

PI_NAMEs: CAMPBELL, MALCOLM GUY (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: addiction;Advisory Committees;Algorithms;Anatomy;Arbitration;Architecture;Association Learning;Axon;Behavior;Brain;Calibration;career;cell type;conditioning;Corpus striatum structure;Cues;Data;design;Disease;Dopamine;Dopamine D1 Receptor;dopamine system;dopaminergic neuron;Dorsal;Electrophysiology (science);Environment;Future;Goals;Habits;Hand;Head;Health;Human;in vivo;Lateral;Learning;learning algorithm;Light;Link;Literature;Machine Learning;Maps;Measures;Modeling;Mood Disorders;Movement;Mus;Nature;NCOA3 gene;neural circuit;Neurons;neurotransmission;Neurotransmitters;novel;Nucleus Accumbens;Odors;Optics;Parkinson Disease;Pattern;Phase;Play;Population;Population Heterogeneity;Postdoctoral Fellow;Process;Research;Resources;response;Rewards;Role;Self Stimulation;Sensory;Shapes;Signal Transduction;Site;skills;System;Techniques;Testing;theories;tool;Training;Update

PROJECT_TITLE: Dissecting the algorithmic and neural circuit basis of dopamine-driven learning in the striatum

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Contraception/Reproduction;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Complications from preterm birth are the leading causes of global mortality in children under the age of five, yet currently there are no predictive diagnostics or preventative therapies for preterm pregnancies. Premature inflammation initiates the biological cascade that results in preterm labor and this proposal investigates the contribution of maternal antibodies to this process, identified using a new robust approach. In this proposal, I will chronicle maternal antibodies through the progression of pregnancy for non-invasive diagnostics development and dissect the molecular pathways that may serve as therapeutic entry points to diminish labor- promoting inflammation.

PI_NAMEs: RACKAITYTE, ELZE  (contact)

PROJECT_TERMS: Advisory Committees;Age;Amino Acids;Animals;antagonist;Anti-Inflammatory Agents;Antibodies;Antigens;Atlases;Autoantibodies;Autoantibody binding;Autoimmune;autoreactivity;Biochemical;Biological;Biological Assay;candidate selection;career;Cells;Child;Chronology;Clinical;cohort;cytokine;Data Set;Development;Diagnostic;diagnostic development;Disease;embryo cryopreservation;Embryo Transfer;Evolution;Exhibits;Failure;Family;fetal;follow-up;Foundations;Future;Generations;Gestational Age;Goals;Grant;Human;Immune;immune modulating agents;Immune system;Immune Tolerance;Immunoprecipitation;in utero;In Vitro;in vivo;Individual;Induced Labor;Inflammation;Inflammatory;Inflammatory Response;inhibiting antibody;Injections;Interleukin-1;Interleukin-1 Receptors;Knowledge;Laboratories;Leadership;Longitudinal cohort;machine learning prediction;Maternal antibody;Maternal autoantibody;Mentors;Metadata;Mission;model building;model development;Modeling;Molecular;mortality;mouse model;nonhuman primate;noninvasive diagnosis;novel;Outcome;paralogous gene;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Phage Display;Phase;Portraits;Pregnancy;Pregnancy Complications;Pregnancy Outcome;premature;Premature Birth;Premature Labor;prevent;Preventive therapy;Process;programs;prospective;protein function;Protein Inhibition;Proteins;Proteome;Recombinant Antibody;Reproducibility;Reproductive Immunology;reproductive system disorder;Research;Resolution;response;Rodent;Role;Scientist;Serology;Serum;Signal Transduction;skills;System;targeted treatment;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;timeline;Training;Women's cohort;Work;Writing

PROJECT_TITLE: Molecular understanding of maternal humoral responses to pregnancy


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE New interventions are urgently needed for diabetic nephropathy, the leading cause of kidney failure in the United States. The proposed work seeks to engineer new materials and technologies for gene therapy in kidney cells. This may lead to new treatments that arrest drivers of diabetic nephropathy and prevent kidney failure.

PI_NAMEs: LIU, GARY  (contact)

PROJECT_TERMS: Accounting;Adhesions;Albumins;Albuminuria;American;Attenuated;Bar Codes;Bioinformatics;Blood;blood glucose regulation;Cell Separation;Cells;Cholesterol;Chronic Kidney Failure;Clinical;Complex;cost;Creatinine;deep sequencing;Diabetes Mellitus;Diabetic Nephropathy;Disease;Disease Progression;DNA;efficacy evaluation;efficacy testing;empowerment;Endothelial Cells;Endothelium;Engineering;ethylene glycol;Exhibits;Extravasation;Faculty;FDA approved;Fibrosis;Flow Cytometry;gene therapy;Genes;Glucose;Goals;Health;Health Care Costs;Healthcare Systems;Hepatocyte;Human;hypertension control;ICAM1 gene;ICAM2 gene;Immune;Immunofluorescence Immunologic;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Insulin-Dependent Diabetes Mellitus;Intercellular adhesion molecule 1;Intervention;Intravenous;Kidney;kidney cell;Kidney Diseases;kidney dysfunction;Kidney Failure;kidney fibrosis;knock-down;Knock-out;Laboratories;large datasets;Lead;Libraries;lipid nanoparticle;Lipids;Liver;Lung;Macrophage;Mediating;Mentors;Messenger RNA;Modeling;mouse model;Mus;nanoparticle delivery;Nephrology;Non-Insulin-Dependent Diabetes Mellitus;nucleic acid delivery;Onset of illness;PECAM1 gene;Pharmaceutical Preparations;Phase;Positioning Attribute;precision medicine;prevent;Property;prophylactic;Proteins;Public Health;recruit;Renal Tissue;Reporter;Reporting;Resources;RNA Interference;RNA Interference Therapy;Role;Safety;screening;Serum;siRNA delivery;Small Interfering RNA;Specific qualifier value;Spleen;Streptozocin;symposium;Technology;Testing;Therapeutic;therapeutic siRNA;Tissues;Training;Treatment Efficacy;Tropism;United States;Up-Regulation;Urinalysis;Western Blotting;Work

PROJECT_TITLE: New siRNA therapeutics to halt diabetic kidney disease


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Precision Medicine;Serious Mental Illness;Tourette Syndrome

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE Tourette Syndrome phenotypic presentations (comorbidity profiles, tic expression, developmental and cyclical patterns over time) vary widely across individuals. This project computationally examines tic change trajectories across 16 weeks using multi-method time series data to assess the impact of a behavioral intervention both within- and between-subjects. Results will inform the development of precision-medicine techniques to improve intervention outcomes.

PI_NAMEs: WELLEN, BRIANNA C (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Affect;Aftercare;Age;Area;Automobile Driving;Award;Behavior Disorders;Behavior Therapy;Brain;career;career development;Childhood;Chronic;Clinical assessments;Clinical Trials;comorbidity;Complement;Complex;Computer Models;Computing Methodologies;contextual factors;Corpus striatum structure;Data;Data Analyses;Data Collection;data integration;Data Set;Decision Making;design;Development;Diagnosis;Diagnostic;Diagnostic Factor;diagnostic strategy;disability;Disease;DSM-V;dynamic system;Ecological momentary assessment;Educational workshop;Electronics;Emotional;evidence base;experience;follow-up;Gilles de la Tourette syndrome;Goals;Heterogeneity;improved;Individual;Individual Differences;Intervention;Intervention Studies;K-Series Research Career Programs;Learning;Literature;Location;Maintenance;Maps;meetings;Mental Health;Mentors;Methods;Modeling;Monitor;Moods;Movement;Nature;Neurocognitive;novel;Outcome;Participant;Patients;Pattern;persistent symptom;Phase;Phenotype;Physiological;Population;post intervention;precision medicine;Prediction of Response to Therapy;Procedures;Process;Psychiatry;Psychology;recruit;Recurrence;Research;Research Project Grants;response;Sampling;Series;Sleep;Statistical Methods;Stress;stressor;Structure;success;suicidal risk;Symptoms;System;Systems Theory;Task Performances;Techniques;Testing;Tic disorder;Time;Training;Treatment outcome;treatment responders;treatment response;vocalization;wearable data;wearable device;Youth

PROJECT_TITLE: Computational Modeling of Tic Change Trajectories in Tourette Syndrome

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

PHR: PROJECT NARRATIVE Membrane tension is thought to be a long-range integrator of cell physiology and a central regulator of many cellular functions including membrane trafficking, cell fate, cell division, and organ homeostasis. We lack a basic understanding of how cells control the range and efficiency of membrane tension propagation. I propose a multipronged approach combining optogenetics, imaging, modelling, and membrane tension measurements to understand how membrane tension functions as a coordinator of cellular behavior.

PI_NAMEs: DE BELLY, HENRY  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Actins;Actomyosin;Architecture;Back;Biochemical;Biophysics;career;career development;cell behavior;Cell division;Cell membrane;cell motility;Cell Physiology;Cell Polarity;Cell Shape;cell type;Cells;Cellular biology;Chemotaxis;Communication;Complication;Contracts;Cytoskeleton;Data;Endothelial Cells;Endothelium;Environment;Event;Experimental Models;Extravasation;Foundations;Goals;Homeostasis;Human;Image;Individual;International;laser tweezer;Leukocytes;Link;Mammalian Cell;mathematical model;Measurement;Measures;Mechanics;Membrane;membrane model;Mentors;Microscopy;migration;Modeling;Monitor;Motion;Movement;neutrophil;novel strategies;optic trap;optic tweezer;optical traps;optogenetics;Organ;Phase;Postdoctoral Fellow;prevent;Principal Investigator;Process;Program Development;programs;Proteins;Research;Role;Scientist;Signal Transduction;Source;spatiotemporal;tenure track;Testing;tool;trafficking;transmission process;Work

PROJECT_TITLE: Membrane tension as a long-range integrator of cell physiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (KR)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

PHR: Nearly 60-85% of Veterans with amputations experience pain at the location of the amputated limb called phantom limb pain (PLP). PLP is a major problem and can have a profound impact on Veteran’s daily function and ability to fully participate in life. Although several rehabilitation interventions are promising, advances in novel rehabilitation interventions are limited. The objective of this project is to refine a mobile app for graded motor imagery in 12 Veterans with amputations and test the mobile app with 36 Veterans with amputations. For this pilot project, we will measure the preliminary feasibility and acceptability of the intervention. Knowledge from this project will provide evidence to guide future larger studies of this graded motor imagery intervention. Developing novel strategies for chronic pain in this population will positively impact quality of life for Veterans with amputations.

PI_NAMEs: RICH, TONYA L (contact)

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Aftercare;Amputation;Augmented Reality;Behavior;Behavior Therapy;Brain;care systems;career;chronic pain;Clinic;Clinical;clinical practice;Clinical Trials;cognitive interview;Community Participation;Consensus;daily functioning;Data;Dedications;design;Development;Effectiveness;eligible participant;Enrollment;equilibration disorder;Evaluation;experience;Feedback;follow-up;foot;Future;Goals;Handedness;Health;health assessment;Home;Home environment;Imagery;Impairment;improved;Individual;Instruction;Intervention;Interview;Investigation;K-Series Research Career Programs;Knee;Knowledge;Learning;Left;Life;limb amputation;Limb structure;Location;Lower Extremity;Measures;Mentors;Mentorship;military veteran;mobile application;Modification;Motor;Movement;Needles;Nervous System;non-drug;novel;novel strategies;Opioid;Outcome;Outcome Measure;Outpatients;Pain;Pain management;painful neuropathy;Patient Outcomes Assessments;Patient Participation;patient-level barriers;Phantom Limb Pain;Pharmaceutical Preparations;Phase;Pilot Projects;Population;post intervention;primary outcome;Process;Process Measure;prototype;Quality of life;recruit;Rehabilitation Outcome;Rehabilitation therapy;remote delivery;Reporting;Research;Research Personnel;retention rate;Sampling;Sedation procedure;Stimulus;Structure;Techniques;telehealth;Telephone;Testing;Therapeutic;Time;tool;Training;usability;verbal;Veterans;virtual;Visual Illusions;Visualization;Voice;Work

PROJECT_TITLE: Home-based rehabilitation intervention for phantom limb pain in Veterans with lower limb amputations

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


PHR: Bipolar disorders (BD) are among the leading psychiatric causes of disability worldwide. Similarly, Veterans with BD are at heightened risk for poor outcomes, such as chronic homelessness, disability, and death by suicide. The early identification of prospective manic and depressive episodes, as well as early detection of declines in functioning, are important components of treating BD and alleviating the suffering of Veterans with BD. The goal of the proposed study is to develop and validate early identification predictive algorithms based on smartphone apps/mHealth measures that are passive, objective, and continuously updating in real-time without requiring patient insight or high effort. If the project is successful, it could provide tools that would enable clinicians to collaborate with Veterans with BD and more effectively time clinical outreach efforts to re-engage Veterans in treatment at the times of greatest need, and subsequently prevent functional impairment and loss of life by suicide.

PI_NAMEs: UROSEVIC, SNEZANA  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Administrator;Algorithms;Bipolar Disorder;Caring;Cellular Phone;Chronic;Clinical;clinical care;clinical implementation;Collaborations;Community Participation;cost;Cross-Sectional Studies;Dairying;Data;Data Analyses;depressive symptoms;Deterioration;diaries;disability;Discipline;Drops;Early Diagnosis;Early identification;Educational process of instructing;effective therapy;Ensure;evidence base;Evidence based treatment;experience;Feedback;flexibility;Focus Groups;follow-up;Frequencies;functional decline;Functional impairment;functional loss;functional outcomes;Funding;Future;Goals;handheld mobile device;Health Personnel;Healthcare Systems;Homelessness;Impairment;Imprisonment;improved;In Situ;indexing;innovation;insight;Intervention;Interview;Lasso;Life;Link;Location;machine learning algorithm;machine learning model;machine learning prediction;machine learning prediction algorithm;Manic;Measures;Mental Depression;Mental Health;Methods;mHealth;military veteran;Modeling;Monitor;Moods;novel;Outcome;Outcome Measure;outreach;Participant;Patient Care;Patient Self-Report;Patients;Pilot Projects;Population;prediction algorithm;prevent;programs;prospective;Provider;psychosocial;psychosocial outcome;random forest;Recurrence;rehabilitation research;Relapse;relapse prevention;Reporting;Research Personnel;residence;retention rate;Risk;Role;routine care;Sampling;Severities;Signal Transduction;Signs and Symptoms;smartphone application;social engagement;Social Functioning;Speech;suicidal morbidity;Suicide;support vector machine;Symptoms;Techniques;Time;tool;Update;Veterans;videoconference;Visit;Voice;wireless electronic;Work

PROJECT_TITLE: mHealth Estimate-based Algorithms Signaling Upcoming Recurrence of Episodes in Bipolar Disorders (MEASURE-BD)

STUDY_SECTION_NAME: Behavioral Health & Social Reintegration[RRD4]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Data Science;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE  Long-term sequelae of COVID-19 infection have a staggering burden on public health and the global economy, but investigators have little understanding of the determinants and mechanisms that underlie this phenomenon. We lack a clear understanding of the role of COVID-19 vaccination timing, or the role of immune biomarkers such as interleukin-6 (IL-6), in determining an individual’s risk of long-term consequences from COVID-19 infection. I will apply innovative Targeted Machine Learning and Causal Inference methods in order to identify an optimal COVID-19 vaccination schedule to minimize the long-term consequences of COVID-19 infection as well as identify mechanistic biomarkers that mediate the relationship between acute COVID-19 and Long COVID.

PI_NAMEs: BUTZIN-DOZIER, ZACHARY  (contact)

PROJECT_TERMS: acute COVID-19;acute infection;Area;Biological;Biological Markers;Biometry;brain fog;California;career;Chronic;cohort;Communicable Diseases;COVID-19;COVID-19 booster;COVID-19 diagnosis;COVID-19 impact;COVID-19 pandemic;COVID-19 sequelae;COVID-19 vaccination;cytokine;Data;Data Science;Data Set;Databases;Death Rate;Diagnosis;Doctor of Philosophy;Dyspnea;electronic health data;Electronic Health Record;Environment;epidemic response;Epidemiologist;Epidemiology;Evaluation;experience;Fatigue;flexibility;Fostering;Frequencies;Funding;Goals;Grant;Guidelines;Immunity;Immunologic Markers;Immunology;Incidence;Individual;Infection;Infectious Disease Epidemiology;Infectious Diseases Research;Informatics;innovation;insight;interest;Interleukin-6;Leadership;Long COVID;long term consequences of COVID-19;long-term sequelae;Machine Learning;machine learning method;machine learning model;machine learning prediction;Mediating;Mediation;Mentors;Mentorship;Methods;multidimensional data;Patients;Play;Policies;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;Probability;prospective;Public Health;Public Health Schools;Recommendation;Recording of previous events;Research;Research Personnel;Risk;Risk Assessment;risk prediction;Role;SARS-CoV-2 infection;semiparametric;skills;Symptoms;Training;Uncertainty;United States National Institutes of Health;Universities;Vaccination;vaccination schedule;Work;Writing

PROJECT_TITLE: Applying a Targeted Machine Learning and Causal Inference Approach to Analyzing Long-Term Sequelae of COVID-19 Infection Through the National COVID Cohort Collaborative.

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Data Science;Dementia;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE To accurately detect preclinical Alzheimer's disease, it is essential to develop early indicators of cognitive decline that can be obtained in real-world settings, and across multiple timepoints. Traditional clinical assessments of older adults are burdensome and may fail to capture momentary shifts in everyday mood or cognition that could identify potential mechanisms associated with cognitive decline. The proposed approach, a naturalistic paradigm to detect cognitive decline, utilizes assessment of older adults in their daily life, enhances ecological validity, and allows for individualized monitoring of subtle changes in three ways: (1) through examination of cross-sectional and longitudinal relationships between cognitive performance, perceived stress, and psychiatric symptoms in an existing sample from the Indiana Alzheimer's Disease Research Center; (2) through natural language processing algorithms designed to detect and quantify risk factors for depression in midlife and older adults; and (3) through an ecological momentary assessment of the daily cognitive functioning, emotions, and stress in older adults, using validated mobile cognitive tasks.

PI_NAMEs: RUTTER, LAUREN  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Address;Adult;Affect;Aging;Algorithm Design;Algorithms;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Area;Artificial Intelligence;Attention;Behavior;Big Data;Biological Markers;career;career development;Characteristics;Clinical;Clinical assessments;Cognition;Cognitive;cognitive ability;Cognitive aging;Cognitive deficits;cognitive function;cognitive performance;cognitive process;cognitive task;cognitive testing;Complex;Computer Models;Data;Data Analyses;Dementia;dementia burden;dementia risk;Depressive disorder;depressive symptoms;Development;Diagnosis;Disease Progression;Early Diagnosis;Early treatment;Ecological momentary assessment;Economic Burden;Educational workshop;Emotions;Environment;epidemiology study;experience;Frustration;Funding;germine;Goals;high risk;Impaired cognition;improved;Indiana;Individual;innovation;Knowledge;Language;Leadership;Learning;Life;Link;Machine Learning;Measures;meetings;Memory Loss;Mental Depression;Mentored Research Scientist Development Award;Mentors;Mentorship;middle age;Monitor;Moods;multimodality;Natural Language Processing;neurocognitive test;neuropsychiatry;older adult;open source tool;participant enrollment;Pathologic;Patients;Pattern;perceived stress;Performance;Personal Satisfaction;Phenotype;Positioning Attribute;pre-clinical;predictive modeling;Process;Progressive Disease;prospective;psychiatric symptom;Psychopathology;Public Health;public health priorities;Recording of previous events;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Sampling;skill acquisition;skills;social media;Speech;Stimulus;Stress;stress symptom;symposium;Symptoms;Techniques;Technology;Testing;theories;Thinking;Time;tool;Training;Universities;wasting;Work;young adult

PROJECT_TITLE: DEVELOPING A NATURALISTIC PARADIGM FOR EARLY DETECTION OF COGNITIVE IMPAIRMENT

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SEATTLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Understanding the relationship between added sugar intake and the oral microbiome will provide important insight on key mechanisms that link behaviors and tooth decay. This knowledge is critical in refining future intervention strategies and policies to promote oral health, prevent cavities, and address oral health inequities in Alaska Native children.

PI_NAMEs: CHI, DONALD LESLIE (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Affect;Age;Alaska Native;Archives;Behavior;Behavior Therapy;Behavioral;Behavioral trial;beta diversity;Biological Markers;Carbon Isotopes;Child;Clinical Research;Communities;Community Health Aides;community intervention;Control Groups;Data;Dental caries;Disease Outcome;Educational process of instructing;Enrollment;Family;Fruit;Funding;Future;Goals;Grant;group intervention;Hair;Health education;health inequalities;Health Status;indigenous community;insight;Intake;Intervention;intervention effect;Knowledge;Link;Measures;Mediator;microbiome;microbiome analysis;Minority Groups;National Institute of Dental and Craniofacial Research;Nitrogen Isotopes;Oral health;oral microbiome;Outcome;Outcome Study;Parents;Policies;preservation;prevent;primary outcome;Process;Public Health;recruit;Ribosomal RNA;Risk Factors;Sampling;secondary outcome;Self Efficacy;Social Behavior;sugar;Surrogate Markers;Taxonomy;Techniques;Testing;Training;Tribes;Vulnerable Populations;Work

PROJECT_TITLE: Microbiome Analysis of Plaque Samples from a Community-Based Socio-behavioral RCT to Reduce Sugared Fruit Drinks in Alaska Native Children

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 AC (08)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioids;Patient Safety;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Each year, an estimated 42 million Americans will receive prescription opioids after surgery, but few will dispose of their leftover opioids. Leftover opioids are often stored insecurely, misused, or shared putting patients, their families, and communities at risk of overdoses, dependence, addiction, and subsequent illicit drug use. This research will lead to an opioid disposal intervention that can be used by pharmacies and hospitals across the country to increase the safe disposal of prescription opioids.

PI_NAMEs: HUANG, LYEN CAMILLE (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adopted;Adoption;American;Back;Behavior;behavior change;Biometry;Cancer health equity;career;chatbot;Chronic;clinical practice;Clinical Trials;Communities;Counseling;Country;Dependence;Drops;Education;Effectiveness;effectiveness/implementation trial;Enrollment;Evaluation;Event;evidence base;Family;feasibility trial;Future;Goals;health literacy;Health Services;Health Services Research;Health system;Healthcare Systems;high risk;Home;Hospitals;Hybrids;Iatrogenesis;illicit drug use;implementation design;implementation outcomes;implementation science;implementation strategy;improved;innovation;Institution;Intervention;Intervention Trial;Leadership;Maps;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;National Center for Advancing Translational Sciences;older adult;older patient;Operative Surgical Procedures;Opioid;opioid disposal;opioid epidemic;opioid overdose;opioid therapy;opioid use;Outcome;overdose risk;Pain management;patient safety;patient-clinician communication;Patients;Perioperative;Pharmacists;Pharmacy facility;point of care;Population;Postoperative Period;pragmatic trial;prescription opioid;Prevention;primary outcome;Primary Prevention;Process;Protocols documentation;Randomized;Research;Research Design;Research Personnel;retention rate;Risk;Rural Community;Scientist;Screening for cancer;Series;skills;smoking cessation;Surgeon;Survey Methodology;Surveys;System;Testing;Text Messaging;theories;Time;Training;treatment arm;trial comparing;Universities;Utah

PROJECT_TITLE: Behavior Change Components to Enhance Opioid Disposal After Surgery

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  Hypersensitivity to auditory stimuli is one of the hallmarks of Fragile X syndrome (FXS). Peripheral auditory neurons and their enveloping satellite glial cells in spiral ganglia form functional units that receive and transmit sound information, but whether functions of spiral ganglia neurons, satellite glial cells or other non-neuronal cells is disrupted and contribute to auditory hypersensitivity in FXS is not known. We propose to define the transcriptional and structural changes in spiral ganglia, and the defects in neuron excitability, with a potential to open new directions to ameliorate sensory deficits in FXS.

PI_NAMEs: CAVALLI, VALERIA  (contact);KLYACHKO, VITALY A

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Action Potentials;Adolescent;Affect;Afferent Neurons;Anxiety;Auditory;auditory stimulus;Auditory system;autism spectrum disorder;Axon;Behavioral;Brain;Candidate Disease Gene;candidate validation;Cell Communication;cell envelope;cell type;Cells;Cochlea;Cognitive deficits;Communication;Data;Data Analyses;Defect;Development;Dissociation;Ear;Electron Microscopy;Environment;experimental study;FMR1 gene;Foundations;Fragile X Syndrome;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;glial cell development;Goals;Hair Cells;Hearing;Hypersensitivity;Immune;Immunofluorescence Immunologic;Impairment;In Situ Hybridization;innovation;Knowledge;Mediating;Membrane;Molecular Profiling;mouse model;Mus;Myelin;myelination;neurodevelopment;Neurodevelopmental Disorder;Neuroglia;neuron development;neuronal cell body;neuronal excitability;Neurons;Nociception;Peripheral;Peripheral Nervous System;postnatal;Property;Proprioception;response;Role;Schwann Cells;Sensory;Sensory Ganglia;sensory input;sensory mechanism;signal processing;single-cell RNA sequencing;Social Interaction;sound;Specificity;Speed;Spinal Ganglia;spiral ganglion;Surface;timeline;transcriptome;transmission process;Whole-Cell Recordings;young adult

PROJECT_TITLE: Unraveling satellite glial cells dysfunctions in spiral ganglia of a mouse model of Fragile X syndrome

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The proposed work will develop a first-of-its-kind, transportable informatics tool, the Population Cancer Assessment and Surveillance Engine (Pop-CASE), that integrates patient-level cancer registry data for a population with granular community- and health system-level data in a standardized data model, while providing a user-friendly query tool to facilitate quick searching by researchers and community outreach professionals. PopCASE will provide a new tool for cancer control researchers, with place-contextualized cancer data at a fine geographic scale. It can also provide the Community Outreach and Engagement (COE) professionals and cancer center leaders working to curb cancer disparities at the local level with an unprecedentedly powerful catchment area data tool.

PI_NAMEs: ROSE, JOHNIE  (contact)

PROGRAM_OFFICER_NAME: TATALOVICH, ZARIA

PROJECT_TERMS: Address;Administrator;Age;American;anti-cancer research;Area;Behavioral Risk Factor Surveillance System;burden of illness;California;Cancer Burden;Cancer Center;Cancer Control;cancer health disparity;cancer invasiveness;Cancer Patient;Caring;Catchment Area;Censuses;Code;Communities;community engagement;Community Outreach;community setting;Community Surveys;comorbidity;Complex;Comprehensive Cancer Center;Computer software;County;Data;Data Analytics;data modeling;data registry;Data Set;Data Sources;data standards;data tools;Databases;Diagnosis;Dimensions;Disadvantaged;Disease;Disparity;disparity reduction;Documentation;Economics;Ethnic Origin;Geography;health professional shortage areas;Health Services;Health system;Home;indexing;Individual;informatics tool;Information Services;Link;Location;Logic;Los Angeles;Malignant Neoplasms;Measures;member;Modernization;Municipalities;neoplasm registry;Ohio;Outcome;Output;Patients;Population;Process;prototype;Provider;Pythons;query tools;Race;Reporting;Research;Research Personnel;Risk Behaviors;Screening for cancer;Secure;social health determinants;Social Work;Source;Specific qualifier value;Standardization;System;tool;United States Food and Drug Administration;Universities;user-friendly;Vertebral column;Vital Status;Work

PROJECT_TITLE: A Multilevel Data Analytic Solution to Advance Population Cancer Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-5 (J1)]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Digestive Diseases;Dissemination and Implementation Research;Immunization;Infectious Diseases;Microbiome;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This K24 proposal will support Dr. Jennifer Downs to train clinical investigators in the conduct of patient- oriented research focused on schistosomiasis and women's reproductive health in resource-limited settings in Tanzania and Lebanon, and to conduct a new study that investigates the effect of schistosome infections on HPV persistence in women in Tanzania. United States trainees will spend >50% of their time at international research sites in Tanzania or Lebanon, with onsite Weill Cornell faculty, long-standing international collaborators, and outstanding environments for research training. All of the projects focus on patient-oriented research on schistosomiasis and/or women's reproductive health and provide a broad experience for trainees in the conduct of mentored research in clinical epidemiology, translational research, and implementation science.

PI_NAMEs: DOWNS, JENNIFER ALZOS (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adult;Affect;Africa;Aftercare;Age;AIDS prevention;Area;Award;biobank;Biopsy;blood pressure control;Caring;Cells;cervicovaginal;Child;Chronic;Clinical;clinical epidemiology;Clinical Investigator;Clinical Sciences;cohort;Cohort Studies;Cytometry;Data;diarrheal disease;Drops;dysbiosis;Effectiveness;Environment;European;experience;Faculty;Family;Family Planning;Female Adolescents;Female genitalia;female reproductive tract;Foundations;Funding;Future;gastrointestinal;Gene Expression;Generations;genital infection;Genitalia;Genotype;girls;global health;Goals;Grant;Gut Mucosa;health goals;Helminths;HPV-High Risk;Human Herpesvirus 2;Human papilloma virus infection;Human Papillomavirus;Immune;Immune response;Immunity;immunoregulation;Impairment;implementation outcomes;implementation science;improved;Incidence;Infant;Infection;Institution;International;international partnership;Intervention;intervention refinement;Intestines;Lactobacillus;Leadership;Lebanon;Male Circumcision;Malignant neoplasm of cervix uteri;Measures;medical schools;Medical Students;Mentors;Mentorship;microbiota;Mid-Career Clinical Scientist Award (K24);modifiable risk;Mucosal Immunity;Mucous Membrane;Muslim population group;National Institute of Allergy and Infectious Disease;neutralizing antibody;next generation;Oral Poliovirus Vaccine;Pathology;patient oriented;patient oriented research;Pharmaceutical Preparations;Physicians;pilot test;Population;Praziquantel;Primary Care;Productivity;Rectum;recurrent infection;Refugees;Religion;reproductive health intervention;reproductive tract;Research;Research Personnel;Research Project Grants;research study;Research Support;Research Training;Resource-limited setting;response;Risk;Risk Factors;Sampling;Schistosoma;Schistosoma mansoni;Schistosomiasis;Schools;Scientist;Sigmoid colon;Site;skills;Standardization;Students;Symptoms;T-Lymphocyte;Tanzania;Time;Tissues;Training;training opportunity;Training Programs;Translational Research;treatment risk;United States;United States National Institutes of Health;vaccine response;Viral;Viral Vaccines;Virus Diseases;Widespread Disease;Woman;Women's Group;women's reproductive health;Work

PROJECT_TITLE: Schistosomiasis and Women's Reproductive Health


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

PHR: Despite existing guidelines, a large proportion of patients with colorectal neoplasia (i.e., polyps and colorectal cancer (CRC)) undergo surveillance (i.e., follow-up) colonoscopy either sooner than recommended (constituting overuse) or later than recommended/not at all (constituting underuse). Surveillance overuse leads to increased healthcare costs, wastes limited resources, and leads to delays in care for those who need colonoscopy more urgently. Underuse increases risk for future CRC. Colorectal neoplasia is categorized according to risk for future CRC. Data show overuse of surveillance for low-risk neoplasia surveillance, but underuse for high-risk neoplasia. This non-adherence to guideline-recommended intervals may be due to patient-, provider-, and/or system-level factors. The proposed research will measure and identify factors associated with surveillance non-adherence in order to develop and pilot test an intervention to optimize appropriate use of surveillance, improving colonoscopy resource use and access in the VHA.

PI_NAMEs: MARATT, JENNIFER KAUR (contact)

PROJECT_TERMS: acceptability and feasibility;Address;adenoma;Adherence;Affect;Age;Award;Barrett Esophagus;Caring;Categories;cohort;Colonoscopy;Colorectal;Colorectal Cancer;Colorectal Neoplasms;comorbidity;Complex;cost;cost estimate;Data;demographics;design;Development;Effectiveness;effectiveness-implementation randomized trial;effectiveness/implementation trial;Endoscopy;Ensure;Equity;Evaluation;evidence based guidelines;Exposure to;Feces;Feedback;follow-up;formative assessment;Fright;Future;Gastroenterology;gastrointestinal;Goals;Guidelines;Health Care Costs;Health care facility;high risk;Hybrids;implementation intervention;Improve Access;improved;Inflammatory Bowel Diseases;innovation;Integrated Health Care Systems;Intervention;intervention mapping;Intervention Trial;Interview;Lesion;Logistic Regressions;low socioeconomic status;Malignant Neoplasms;Measures;medical specialties;Methodology;Methods;Modeling;Neoplasms;Oncology;Operative Surgical Procedures;Patient-Centered Care;Patients;Persons;pilot test;Polyps;Population;Positioning Attribute;Precancerous Polyp;Preventive service;Primary Care;primary outcome;Process;programs;Provider;Qualitative Methods;Recommendation;Research;Resources;Risk;rural area;Sampling;screening;Site;skill acquisition;skills;social health determinants;Structure;surveillance study;System;Testing;theories;therapy design;therapy development;Time;Training;Veterans;Veterans Health Administration;wasting;Work

PROJECT_TITLE: Addressing Under- and Overuse of Colorectal Neoplasia Surveillance Among Veterans

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Aging;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE As we age, our tissues become less resilient towards damage or injury, which increases our risk for developing a disease. Factors, such as chronic stress, diet, and genetic predisposition can accelerate this process, thereby causing early disease onset, such as Early-Age Onset Colorectal Cancer (EAO CRC). In this project, we will test the idea that EAO CRC patients have intestinal cells with characteristics of old age and identify possible targets for treatment, with a focus on African-American patients.

PI_NAMEs: ALEXANDER, JENNIFER IMENA (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;African American;African American population;Age;age group;Age of Onset;age-related disease;Aging;aging biomarker;aging mechanism;aging related;aging related disease;American;Automobile Driving;Autophagocytosis;Binding;Bioinformatics;Biology of Aging;burden of illness;cancer biomarkers;cancer health disparity;Candidate Disease Gene;career networking;cell age;Cell Aging;Cells;Characteristics;Chronic stress;Chronology;Clinical;Collaborations;Colon;colon cancer patients;Colorectal Cancer;Communities;Coupled;Cues;Data;Data Set;Development;Diet;dietary;differential expression;Disease;disease disparity;Disease susceptibility;Drosophila genus;Equilibrium;Erinaceidae;European;Event;Exhibits;experience;Experimental Models;fly;Funding;Gene Expression;Genes;Genetic;Genetic Determinism;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Goals;Grant;Growth Factor;health disparity;Human;human old age (65+);Incidence;Individual;Injury;interest;Intestines;Investigation;Knowledge;Life Cycle Stages;life span;Link;Malignant Neoplasms;Maps;Mediating;Modeling;Molecular;Molecular Genetics;mutant;Natural regeneration;novel;Onset of illness;Organoids;Outcome;Ovarian;Pathogenesis;Pathway interactions;Patients;Phase;Phenotype;Population;Predictive Factor;Premature aging syndrome;preservation;prevent;Process;programs;Proliferating;regenerative;repaired;Reporting;Research;resilience;Risk;Risk Factors;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;stem cells;Technical Expertise;Testing;therapeutic target;Time;tissue regeneration;tissue repair;Tissue-Specific Gene Expression;Tissues;tool;Transcript;transcriptome;transcriptomics;tumor;tumorigenesis;Universities

PROJECT_TITLE: Balancing Cellular Repair and Regeneration in Aging and Disease

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Mortality is rising among Medicare beneficiaries with HF, and evidence suggests this may be partially due to gaps in health care access and affordability. This study aims to evaluate recent Medicare policy changes that could meaningfully address these gaps by: (1) comparing care quality and outcomes between HF patients enrolled in Medicare Advantage vs fee-for-service Medicare; (2) evaluating the impact of the Inflation Reduction Act (2022) on medication access and adherence for HF patients; and (3) using semi-structured interviews of patients and clinicians to identify ongoing and/or new barriers in HF care access, affordability, and medication adherence, as well as novel strategies to address them. This study could have significant public health implications as clinicians and policymakers seek innovative ways to improve outcomes among older patients with HF.

PI_NAMEs: OSERAN, ANDREW SEYMOUR (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Ambulatory Care;barrier to care;beneficiary;care delivery;care outcomes;career;career development;Caring;Clinical;Clinical Investigator;cost;Data;design;Development;Development Plans;Drug Costs;Drug Prescriptions;econometrics;Enrollment;experience;Fee-for-Service Plans;Foundations;Future;future implementation;Goals;Government;Growth;Guidelines;Health Benefit;health care availability;Health Services Accessibility;Heart failure;hospital readmission;Hospitalization;improved;improved outcome;Individual;innovation;insurance plan;Interruption;Intervention;Interview;Low income;Measures;Medical;Medicare;Medicare claim;medication compliance;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;mortality;Nature;novel strategies;older patient;Outcome;Outcome Assessment;participant enrollment;Patients;payment;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;Privatization;programs;Public Health;Qualitative Methods;Quality of Care;Quasi-experiment;rapid growth;readmission rates;recruit;Research;Savings;Scientist;Series;skills;Statistical Methods;Structure;Subgroup;Surveys;Testing;therapy adherence;Time;Treatment Failure;United States;Work

PROJECT_TITLE: Evaluating Policies to Improve Heart Failure Outcomes in Medicare

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (J3)]


ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE CRISPR-Cas genome editing enzymes have the potential to treat infectious and pulmonary diseases in the lung but delivering them specifically to diseased cells is a challenge. This proposal will determine how lentivirus-like particles package and deliver Cas9 with its guide RNA to specific cell types and how this mechanism can be harnessed for genome editing of lung epithelia, a tissue implicated in many diseases. The development of a specific delivery method for CRISPR-Cas editing components in lung epithelial cells will be transformative for genetically treating lung diseases.

PI_NAMEs: DOUDNA, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;adenovirus mediated delivery;Alveolar Macrophages;Animal Model;Antibodies;antibody engineering;antibody test;Behavior;Binding;Biology;Biomedical Engineering;Blood;Blood Vessels;Capsid;Capsid Proteins;Cell surface;cell type;Cells;Chemicals;chimeric antigen receptor T cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Common Epitope;Communicable Diseases;Cone;CRISPR/Cas technology;Data;delivery vehicle;Dependovirus;design;Development;Diameter;Disease;Elements;Encapsulated;Engineering;Enzymes;Epithelial Cells;Epithelium;Epitopes;experimental study;Future;Genetic;Genetic Diseases;genome editing;Glycoproteins;Guide RNA;Heart;Hepatocyte;Human;humanized mouse;Immune Tolerance;Immunoglobulin Fragments;improved;In Vitro;in vivo;inhibitor;insight;interest;Laboratories;Lentivirus;Libraries;lipid nanoparticle;Liver;Liver diseases;Lung;lung development;Lung Diseases;manufacturing process;Mediating;Methods;Mus;nanoparticle;nanoparticle delivery;Outcome;particle;Patients;Peptide Hydrolases;polypeptide;Production;Proteins;rational design;respiratory virus;Ribonucleoproteins;Risk;screening;Shapes;Side;small molecule inhibitor;Source;Specificity;Structural Protein;Structure;Structure of parenchyma of lung;Surface;surfactant;T-Lymphocyte;targeted delivery;Tissues;tool;Tropism;uptake;Variant;Viral;Viral Genome;Virus;Virus-like particle

PROJECT_TITLE: Targeted Delivery of Cas9 to Lung Epithelial Cells using Enveloped Delivery Vehicles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Narrative In the US, disparities in maternal and child health (MCH) across socioeconomic status, race/ethnicity, and geography are pervasive with little evidence of improvements despite significant investments. Addressing these disparities requires characterizing the structural drivers of MCH and their association to health to inform the design of multi-level, upstream interventions and policies. The goal of this project is to apply novel and rigorous data science and analytic tools to address significant gaps in our understanding of how structural drivers are geographically patterned and generate racial/ethnic MCH disparities from preconception to birth.

PI_NAMEs: MARTINEZ-CARDOSO, ARESHA MAREE (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Address;Advisory Committees;Age;analytical tool;Area;Award;big-data science;Birth;Birth Records;Caliber;Censuses;Classification;Clinical;Communities;Conceptions;County;COVID-19;COVID-19 mortality;Data;Data Analyses;Data Analytics;Data Science;Data Set;deprivation;design;Developed Countries;Development;Dimensions;disparities in women;Disparity;disparity reduction;Economics;Education;Equity;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;Ethnic Population;Geographic Locations;Geography;Goals;Growth;Health;Health behavior;health disparities in women;health disparity;health inequalities;Health Policy;Health Resources;Heterogeneity;Housing;improved;indexing;Individual;Inequality;Inequity;Infant;Infant Mortality;Infrastructure;innovation;Institution;Intervention;Investments;Latinx;Link;Location;low socioeconomic status;Machine Learning;machine learning method;marginalized population;Maternal and Child Health;Maternal Mortality;Measures;Mediating;Medical;Mentored Research Scientist Development Award;Mentors;Methodology;Methods;Modeling;mortality;multilevel analysis;National Health Interview Survey;Nature;novel;Occupations;Outcome;Pattern;Perinatal;perinatal health;perinatal outcomes;Policies;Politics;Population;Public Health Education;Race;racial disparity;racial health disparity;racial minority;racial population;reproductive;Research;Research Personnel;Role;rural area;rurality;Schools;Shapes;social;social determinants;social factors;social health determinants;socioeconomic disparity;Socioeconomic Status;Stress;structural determinants;System;Testing;tool;Training;Training Programs;Typology;United States;Vital Statistics;Women's Health;women's reproductive health;Work

PROJECT_TITLE: Investigating structural drivers of maternal and child health inequities: a geospatial and data science approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


ADMINISTERING_IC: ES

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

PHR: PROJECT NARRATIVE Pregnant women are exposed to an increasing number of environmental contaminants in their daily life, with potential harmful effects for the developing nervous system of the fetus. These exposures during early stages of fetal brain development can cause persistent changes and increase the risk on Alzheimer’s Disease and related dementia (ADRD) later in life. This project aims to provide training to independence via development of an in vitro placental-fetal brain model to investigate early-life exposures impact on later-life susceptibility to brain diseases including ADRD.

PI_NAMEs: TUKKER, ANKE MARIJE (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Adult;Age;age related neurodegeneration;aging brain;Air;Alzheimer's disease related dementia;Bioinformatics;Biological Models;Blood - brain barrier anatomy;Blood specimen;Brain;Brain Diseases;career;Cell Line;Cells;Chemicals;Chlorpyrifos;Collaborations;cytotoxic;Data;Databases;dementia risk;Development;Development Plans;Diethylhexyl Phthalate;Disease;disorder risk;Dust;early life exposure;Embryonic and Fetal Development;Engineering;Environment;Environmental Pollutants;exposed human population;Exposure to;fetal;Fetal Development;Fetus;Food;functional outcomes;Future;Genetic;Glucose;Goals;Health;Heavy Metals;Human;human induced pluripotent stem cells;human stem cell-derived;human stem cells;Imaging Techniques;In Situ;In Vitro;in vitro Model;in vitro testing;Induced pluripotent stem cell derived human neuron;late life;Lead;Life;Link;Literature;Maintenance;Mass Spectrum Analysis;Mentors;Metabolic;Metabolic Pathway;Metals;Methylmercury Compounds;Microelectrodes;Modeling;Nervous System;Neurodegenerative Disorders;neurodevelopment;Neurologic;Neurologic Effect;Neurons;neuropathology;neurotoxic;Neurotoxins;novel;Organophosphates;Outcome;Pathway Analysis;Pathway interactions;Performance;Pesticides;Phase;Phenotype;phthalates;Physiology;Placenta;Placental Biology;Plasticizers;Positioning Attribute;Postdoctoral Fellow;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;Privatization;Prosencephalon;Protocols documentation;Reproducibility;reproductive;Research;Research Personnel;Risk;Sampling;Scientist;single-cell RNA sequencing;skills;statistics;stem cell model;System;Testing;Toxic effect;Toxic Environmental Substances;toxicant;Toxicology;Training;trophoblast;Umbilical Cord Blood;Urine;Water

PROJECT_TITLE: Human stem cell derived forebrain model to study persistent neurotoxic effects of trans-placental developmental exposures to environmental pollutants

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-W (K9)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Lymphatic Research;Lymphedema;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative Every breast cancer survivor is at lifetime risk of developing breast cancer-related lymphedema. The Nurses’ Health Study longitudinal database enables us to explore patterns of association between breast cancer diagnosis and lymphedema symptom development. These findings can inform clinical practice guidelines and health system policies and support local and national survivorship initiatives.

PI_NAMEs: ANDERSON, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Age;age related;anti-cancer treatment;associated symptom;Body Image;Body mass index;Breast;breast cancer diagnosis;Breast Cancer Risk Factor;breast cancer survival;Breast Cancer survivor;Breast Cancer survivorship;Breast Cancer Treatment;Characteristics;chemotherapy;Chest;Chronic Disease;Clinical Practice Guideline;cohort;Cohort Studies;comorbidity;Data;database design;Databases;Development;Diagnosis;Diet;emotional distress;Employment Status;Excision;experience;Foundations;Future;Grain;Health;Health Status;Health system;Incidence;infection risk;innovation;interstitial;Life Style;lifetime risk;Limb structure;longitudinal database;longitudinal dataset;Lymph;lymph nodes;Lymphatic System;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Measures;Modality;Modeling;novel;Nurses;Nurses' Health Study;Operative Surgical Procedures;Pain;Participant;Patient Self-Report;Pattern;Persons;Phase;Physical activity;Physical Function;Policies;Prevalence;programs;prospective;Proteins;psychosocial;Quality of life;Questionnaires;Race;Radiation;Radiation therapy;Recording of previous events;Registered nurse;Reporting;Reproductive Health;reproductive system disorder;Research;Research Personnel;residence;Risk;Sampling;Secondary to;Self Management;side effect;Skin;Socioeconomic Status;statistics;Surveys;Survivors;survivorship;Swelling;Symptoms;therapy development;Time;Tissues;trend;United States;Weight;Woman;women's treatment;Work

PROJECT_TITLE: Nurses Surviving Breast Cancer: An exploration of breast cancer diagnosis, reported lymphedema symptoms, and lifestyle status in the Nurses' Health Study Survey

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J2)]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Racial/ethnic minority and uninsured populations experience persistent cervical cancer disparities due to under-screening. HPV self-sampling, a new screening option, could transform and increase access if implemented by federally qualified health centers (FQHCs) who serve these vulnerable populations. Our large pragmatic trial will test strategies for offering HPV kits during clinic encounters and by mail to speed implementation efforts in low resource healthcare settings.

PI_NAMEs: PETRIK, AMANDA F.;TIRO, JASMIN ANITA;WINER, RACHEL L. (contact)

PROGRAM_OFFICER_NAME: CHOLLETTE, VERONICA

PROJECT_TERMS: Adherence;Adopted;Adoption;arm;cancer health disparity;care systems;Caring;Cervical Cancer Screening;Characteristics;Clinic;Clinical;clinical practice;community based participatory research;comparative effectiveness;compare effectiveness;Cost Analysis;cost effectiveness;COVID-19 pandemic;Data;design;Diagnosis;Disparity;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;Enrollment;ethnic minority;evidence base;experience;Federally Qualified Health Center;flexibility;follow-up;France;health care settings;health plan;Health Resources;Healthcare Systems;Home;Human Papillomavirus;Hybrids;implementation efforts;implementation evaluation;implementation strategy;Individual;Instruction;International;Intervention;Maintenance;Malignant neoplasm of cervix uteri;Medicaid;Methods;minority disparity;Oregon;participant enrollment;patient oriented;patient population;Patients;Persons;Phase;pilot test;pilot trial;Population;pragmatic randomized trial;pragmatic trial;Preventive care;Preventive service;primary outcome;programs;Protocols documentation;Provider;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Resource-limited setting;Resources;routine screening;safety net;Sampling;screening;screening disparities;self testing;sociodemographics;Spanish;Speed;telehealth;Testing;treatment as usual;Underinsured;Uninsured;Visit;Vulnerable Populations;Washington

PROJECT_TITLE: Self-Testing for Cervical Cancer in Priority Populations: the STEP-2 Trial

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Contraception/Reproduction;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Endocrine-disrupting chemicals have been identified as potential ovarian toxicants and linked to impaired fertility, which is a common issue experienced by ~15% of couples. The proposed research will advance systematic exposome approaches to investigate how complex exposures to thousands of chemicals impact ovarian health and female fertility. This research will also evaluate personal care product habits and their associated racial/ethnic disparities as potential sources to inform future exposure reduction interventions.

PI_NAMEs: YOUNG, ANNA SWIFT (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Affect;Assisted Reproductive Technology;Automobile Driving;Award;Biological;Biological Markers;Black race;black women;Blood;Blood specimen;California;career;career development;Caring;Categories;Chemical Exposure;Chemicals;Clinical;cohort;Complex;Complex Mixtures;computer science;Cosmetics;Couples;Data Science;Databases;design;Development;Disease;Disparity;Endocrine Disruptors;Environment;environmental chemical;Environmental Epidemiology;Epidemiologic Methods;ethnic disparity;ethnic diversity;Ethnic Origin;Etiology;Evaluation;experience;Exposure disparity;exposure reduction interventions;Exposure to;Female;female fertility;Female infertility;female reproductive system;Fertility;Fertility Study;Fingerprint;Follicular Fluid;Future;General Population;Goals;Habits;Health;Human;Impairment;implantation;Infertility;innovation;insight;Intervention;Laboratories;Link;Live Birth;Machine Learning;machine learning algorithm;Maps;Mass Spectrum Analysis;Massachusetts;Measurement;Measures;Mentors;Meta-Analysis;Metabolic Pathway;metabolome;metabolomics;multidisciplinary;multiple omics;novel;oocyte quality;Oocytes;Organ;Outcome;Ovarian;ovarian dysfunction;Ovary;Pathway interactions;Patient Self-Report;perceived discrimination;personal care products;Positioning Attribute;predictive marker;Pregnancy;programs;prospective;Race;racial disparity;Registries;reproductive;reproductive epidemiology;Reproductive Health;reproductive organ;reproductive system disorder;Research;Resolution;Resources;Role;Sampling;Sister;Source;Specimen;Surveys;symposium;toxicant;Training;Urine;web site;Woman;Women's cohort;women's outcomes

PROJECT_TITLE: Mapping the cosmetic  chemical exposome and its role in female fertility


NIH_SPENDING_CATS: Clinical Research;Human Fetal Tissue;Immunotherapy;Organ Transplantation;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The U.S. recently celebrated a million cases of solid organ transplantation, and more than four hundred thousand people are living with a functioning allograft. Despite this life-saving operation, a lack of effective tolerogenic therapeutics is a critical barrier to long-term allograft survival. This project seeks to develop novel strategies to promote allograft tolerance via targeted activation of HLA-E-restricted regulatory CD8 T cells.

PI_NAMEs: CHOI, JOHN YONGJOON (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Allograft Tolerance;Allografting;alpha-beta T-Cell Receptor;Amino Acids;Antibodies;antibody-mediated rejection;Antigens;Award;B-Lymphocytes;Binding;biobank;Biology;Blocking Antibodies;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;clinically relevant;Complex;cytotoxicity;Data;design;effective therapy;efficacy validation;Engineering;Failure;fetal;Goals;Hematopoietic stem cells;Histology;Human;humanized mouse;Immune;Immunotherapy;Implant;improved;In Vitro;in vivo;Inflammatory;inhibiting antibody;inhibitor;isoimmunity;Kidney;Kidney Transplantation;Libraries;Life;Liver;MAPK3 gene;Measures;Mediating;Modeling;mouse model;Mus;Mutagenesis;Nature;novel;novel strategies;NR0B2 gene;operation;Organ Transplantation;organoid transplantation;Organoids;Pathogenicity;Peptides;Peripheral Blood Mononuclear Cell;Persons;phase I trial;Phosphorylation;Physiologic pulse;Play;Positioning Attribute;pre-clinical;Protein Tyrosine Phosphatase;Qa-1 Antigen;receptor;Receptor Inhibition;Receptor Signaling;recruit;Regulatory T-Lymphocyte;response;Role;Sampling;selective expression;Signal Transduction;Signaling Molecule;skills;Small Interfering RNA;Solid;Stress;Structure of germinal center of lymph node;Surface;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;Thymus Gland;tool;translational study;transplant model;Transplant Recipients;Transplantation Tolerance;Vaccinated;Vaccines;Variant;Yeasts;ZAP-70 Gene

PROJECT_TITLE: Enhancing the TCR-induced Response of HLA-E-restricted Regulatory CD8 T Cells to Promote Allograft Tolerance

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE American Indians are disproportionately affected by cardiometabolic diseases, and these disparities may be due, in part, to socioeconomic inequities that burden American Indian communities. An understanding of the biological mechanisms that may be involved in the socioeconomic determinants of cardiometabolic health will be instrumental to abrogating cardiometabolic disease disparities in American Indians; thus, this proposal will provide a comprehensive examination of feasible epigenetic mechanisms that may underlie the effects of socioeconomic adversity on cardiometabolic disease risk in American Indians. Findings from this study will improve our understanding into the importance that socioeconomic determinants have on cardiometabolic health in American Indians with relevance to other susceptible populations, and it will provide compelling evidence that will be instrumental towards developing preventative strategies and precision medicine approaches to addressing socioeconomic inequities and cardiometabolic disease disparities.

PI_NAMEs: DYE, CHRISTIAN K (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Address;Advisory Committees;Affect;American Indian community;American Indian Population;American Indians;Arizona;Attention;Award;Biological;Biology;Cardiometabolic Disease;cardiometabolism;career;career development;causal model;Cells;Clinical;Cohort Studies;Communities;Complex;Data;Data Science;Dedications;Development Plans;Diagnostic;Dimensions;Disease;disease disparity;Disease Progression;disorder risk;Disparity;diverse data;DNA;DNA Integration;DNA Methylation;Dyes;Early Diagnosis;Economic Conditions;economic determinant;Economics;Environment;Epidemiology;epigenetic aging;Epigenetic Process;epigenome;epigenomics;Face;Family;Family member;Family Study;follow-up;Fostering;gene environment interaction;Genomic approach;Geography;Glucose Intolerance;Goals;Health;Health behavior;health determinants;Health Disparities Research;health disparity;health inequalities;Health Sciences;Heart;high dimensionality;high risk;Hyperglycemia;Immune;improved;Indigenous;indigenous community;Individual;Inequity;Inflammation;Inflammatory;insight;Insulin Resistance;Intervention;Investigation;Link;Measures;Mentors;Mentorship;Metabolic;Metabolic syndrome;Methodology;methylomics;Molecular;Molecular Epidemiology;multiple omics;Neighborhoods;North Dakota;novel;Oklahoma;Participant;Pathogenesis;Pathway interactions;Phase;Phenotype;Policies;Population;Positioning Attribute;precision medicine;Predisposition;Prevalence;preventable death;Prevention strategy;Preventive Medicine;prognostic;Prospective cohort;Proteomics;Research;response;Risk;Risk Factors;Role;Signal Pathway;skills;social;social determinants;social epidemiology;sociodemographics;socioeconomic adversity;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;socioeconomics;South Dakota;targeted treatment;Therapeutic;Training;Tribes;underserved community;Variant;Visit;Vulnerable Populations

PROJECT_TITLE: The epigenetic basis of socioeconomic determinants of cardiometabolic health in American Indians

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (J1)]