NIH_SPENDING_CATS: Dietary Supplements;Digestive Diseases;Genetics;Infectious Diseases;Microbiome;Nutrition;Prevention

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Soil-transmitted helminth infections represents a significant global public health and economic burden. Therefore, there is an urgent need to improve our understanding of genetic and environmental modulators of type 2 cytokine-dependent immunity in order to identify novel preventative and therapeutic approaches for this group of infectious agents. Based on our new preliminary data, the focus of this proposal is to dissect the influence of diet-induced modulation of microbiota-derived metabolites in regulating type 2 cytokine responses and protective immunity to helminth infection.

PI_NAMEs: ARTIS, DAVID  (contact);GUO, CHUN-JUN

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: absorption;Acceleration;Acids;Address;Adoptive Cell Transfers;Allergic Disease;allergic response;Anemia;Antiinflammatory Effect;B-Lymphocytes;Bacteria;bile acid metabolism;Bile Acids;Biological;Biology;Blood Circulation;Brain;Cells;Chemicals;Cholic Acids;Chronic;cognitive function;Communicable Diseases;comparative;cytokine;Data;dehydroxylation;Deoxycholic Acid;Development;Diet;Dietary Component;Dietary Fiber;dietary requirement;Distant;Economic Burden;Economics;Environmental Risk Factor;eosinophil;Eosinophilia;Fermentation;Fiber;Gene Deletion;Gene Expression;Gene Expression Profiling;Genetic;genetic approach;Genetic Engineering;Germ-Free;Growth;helminth infection;Helminths;IgE;Immune;Immune response;Immunity;Immunoglobulin G;Immunologics;immunopathology;immunoregulation;Impaired cognition;improved;In Vitro;in vivo;Individual;Indoles;Infection;infection rate;Infectious Agent;Inflammation;Inflammatory;Inflammatory Response;Intestines;Inulin;Lymphoid Cell;Macrophage;Malnutrition;Mammalian Cell;Mediating;member;mesenchymal stromal cell;Metabolic;Metabolic Pathway;metabolomics;microbial;microbiota;microbiota composition;microbiota metabolites;mouse model;Mus;mutant;neglect;novel;overexpression;Parasites;Parasitic infection;Pathway interactions;Persons;Physiological;prevent;Production;Public Health;receptor;Regulation;response;Role;secondary metabolite;Site;Soil;Source;Stromal Cells;Testing;Th2 Cells;Therapeutic;Tissues;tool;transcriptional reprogramming;transcriptomics;transmission process;Volatile Fatty Acids

PROJECT_TITLE: Microbiota-derived metabolites and the regulation of host immunity and inflammation (Diversity Supplement)

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Population genomic inference currently assumes that all segregating mutations are neutral and does not account for the effects of selection across the genome, which is problematic when modeling genomic variation in species with compact genomes (i.e., those with a high density of protein-coding and regulatory regions) where natural selection is pervasive. The goal of this project is to generate a more accurate estimate of the fitness effects of new mutations across the genome and to develop statistical and computational methods that simultaneously account for the effects of selection jointly with other evolutionary processes to make accurate evolutionary inferences using sequence variation from natural populations. As most pathogenic species tend to have highly compact genomes and experience strong bouts of selection and drastic repeated bottlenecks, our methodological advances and their applications would be absolutely essential to uncovering the population and selective history of human pathogens.

PI_NAMEs: JOHRI, PARUL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Affect;Asexual Reproduction;Code;Computing Methodologies;Data;Demography;density;Development;DNA;DNA Sequence;Elements;Environment;Event;experience;fitness;Genes;Genetic;Genetic Recombination;Genetic Variation;Genome;genome-wide;genomic variation;Genomics;Goals;Human;human disease;human migration;human pathogen;Individual;information model;insight;Joints;Learning;Methodology;Methods;Modeling;Mutation;Natural Selections;Nucleic Acid Regulatory Sequences;pathogen;Pathogenicity;Pattern;Plasmodium falciparum;Plasmodium vivax;Population;pressure;Process;programs;Proteins;Recording of previous events;Research;segregation;Self-Fertilizations;Shapes;Site;Statistical Methods;trait;Untranslated RNA;Variant;whole genome;Work

PROJECT_TITLE: Jointly modeling the effects of evolutionary processes on genomic variation

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Behavioral Research on Acculturation and moderating and mediating Variables Observed Specifically among Latinos: BRAVOS Project Narrative Childhood obesity is on the rise and disparities exist particularly among Latino preschool-aged children and approximately half of Latino kindergarteners in Nevada are overweight or obese. It is crucial to identify determinants of childhood obesity and one possible determinant of obesity is parental acculturation to the United States. The purpose of this project is to examine the longitudinal association of parental acculturation with child outcomes: fruit and vegetable intake, and BMI by using a new technology, skin carotenoid spectroscopy which measures biomarkers of fruit and vegetables (carotenoid intake) that is fast, and easy to use to measure child’s fruit and vegetable intake which can help identify and monitor child’s fruit and vegetable intake and to promote healthier dietary patterns.

PI_NAMEs: JOHANSEN, CHRISTOPHER MARTIN (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: 5 year old;Acceleration;acceptability and feasibility;Acculturation;Adolescent;Adult;Affect;Age;Award;Behavior;Behavioral Research;Biological Markers;Body mass index;Body Weight;Cardiovascular Diseases;Carotenoids;Child;Child Health;Childhood;cohort;community based participatory research;Community Health;comorbidity;Consumption;cooking;Cross-Sectional Studies;Data Reporting;Development;Diabetes Mellitus;Diet;dietary;Dietary Practices;Disparity;early childhood;Education;Eligibility Determination;energy density;Ethnic Population;fatty liver disease;feasibility testing;Fiber;Food;fruits and vegetables;Growth;Health behavior;Health Disparities Research;Hormones;Hour;Income;Individual;Intake;Intervention;Latino;Latino Population;Latinx;Longitudinal cohort;Longitudinal Studies;Low income;Malignant Neoplasms;Measurement;Measures;Mediating;Mediation;Mediator;member;Mesoamerican;meter;microbial;Monitor;Nevada;new technology;Nursery Schools;Obesity;obesity in children;obesity prevention;obesity risk;Outcome;Overweight;Parents;Patient Self-Report;polyphenol;Prevalence;Process;programs;Proxy;psychologic;Public Health;Public Health Schools;recruit;Reporter;Research;Research Design;Research Personnel;Risk Reduction;Sampling;Satiation;School-Age Population;sex;Skin;social cognitive theory;sociodemographic variables;Spectrum Analysis;tool;Training Support;undergraduate student;United States;Vegetables

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SB)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Cancer treatment can cause side effects on the heart including arrhythmias. Cardiospheres derived from stem cells can provide a new model for efficient detection of drug-induced cardiotoxicity, which will improve the safety of cancer treatment. Our high throughput assay will also allow to examine antiarrhythmic drugs in human cardiospheres in a highly efficient manner, facilitating future effort on large-scale drug discovery study which is challenging with animal models.

PI_NAMEs: XU, CHUNHUI  (contact)

PROGRAM_OFFICER_NAME: DIMOND, EILEEN

PROJECT_TERMS: 3-Dimensional;Adverse event;Animal Model;Animals;Anthracycline;Anti-Arrhythmia Agents;Arrhythmia;Behavior;Biological Assay;Biology;cancer therapy;Cardiac;Cardiac Myocytes;cardioprotection;Cardiotoxicity;Cell model;Cells;Characteristics;Chemicals;chemotherapeutic agent;chemotherapy;Clinical;clinical trial in a dish;clinically relevant;Code;computerized tools;Detection;Development;Disease;disease model;disease phenotype;Dose;drug discovery;drug testing;effective therapy;Equipment;Evaluation;FDA approved;Functional disorder;functional outcomes;Future;Goals;Growth;Heart;Heart failure;high throughput screening;high-throughput drug screening;Human;human induced pluripotent stem cells;human model;improved;Investigation;Investigational Therapies;Maintenance;Microscope;Modeling;new therapeutic target;novel;Pathologic;Pharmaceutical Preparations;Pharmacotherapy;Physiological;Physiology;Play;Proteasome Inhibitor;response;Risk;Role;Ryanodine Receptor Calcium Release Channel;Safety;screening;side effect;small molecule libraries;stem cells;Technology;Therapeutic;Tissue Engineering;Tissues;tool;translational potential

PROJECT_TITLE: High-throughput assessment of chemotherapy-induced cardiotoxicity in 3D human cardiomyocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-Z (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Telehealth;Transplantation

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: This proposal supports the NCI’s public health goal of improving the quality of survival of persons diagnosed with cancer and the goal of preventing, minimizing, or managing adverse effects of cancer and its treatment. It does so by advancing evaluation of a novel intervention that pairs a collection of first-hand, survivor-written peer support narratives with coordinated educational content and stress/coping resources for hematological patients preparing for, undergoing, and recovering from hematopoietic stem cell transplant. If successful, this research would yield a low-cost, scalable intervention that fills a gap in supportive resources for transplant recipients.

PI_NAMEs: RINI, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: 2 arm randomized control trial;Adverse effects;Affect;anxiety symptoms;Automobile Driving;Award;Behavior;Cancer Patient;Clinical;Collaborations;Collection;community advisory board;coping;cost;cost effective;Data;Decision Making;depressive symptoms;design;Diagnosis;digital health;Distress;Education;efficacy testing;Emotional;Emotions;empowerment;Ensure;Ethnic Origin;Evaluation;experience;Face;Focus Groups;Foundations;Funding;Future;Goals;Growth;health care service organization;health goals;Health Personnel;health related quality of life;Hematology;Hematopoietic Stem Cell Transplantation;hospital readmission;Hospitalization;Improve Access;improved;improved outcome;Infection;Information Resources;Intervention;Interview;Language;Link;Longitudinal Studies;Malignant Neoplasms;Mediator;Medical;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;mosaic;Motivation;novel;online resource;Online Systems;optimism;Outcome;Participant;Patient Education;Patient Outcomes Assessments;Patient Recruitments;Patient-Focused Outcomes;patient-level barriers;Patients;peer;peer coaching;peer support;perceived stress;Persons;physical conditioning;physical symptom;prevent;Preventive;Preventive care;primary endpoint;primary outcome;Problem Solving;programs;Provider;psychoeducation;psychologic;psychological distress;psychosocial stressors;Public Health;Qualitative Methods;Quality of life;Race;Randomized;Randomized, Controlled Trials;Reaction;Readiness;Recovery;Reporting;Research;Resources;Risk;Risk Reduction;Schedule;secondary outcome;Self Efficacy;sex;side effect;Social isolation;Spanish/English;Stem cell transplant;Stress and Coping;stress management;Structure;Survivors;Symptoms;telehealth;Testing;theories;Time;Training;Transplant Recipients;transplant survivor;treatment adherence;treatment as usual;Treatment-related toxicity;usability;web site;Writing

PROJECT_TITLE: Mosaic: RCT of a Digital Health Intervention Delivering Peer Support Narratives and Psychoeducation to English- and Spanish-Speaking Stem Cell Transplant Recipients

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: Project Narrative Risk factors for heart attack and stroke are linked to dementia, including Alzheimer’s Disease. By using recently validated methods to identify transgender persons in existing data, this project will build on prior work assessing risk factors in transgender persons and characterize rates of dementia in this population.

PI_NAMEs: STREED, CARL G (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Administrative Supplement;Adult;Aging;Alzheimer's Disease;Area;Atherosclerosis;Boston;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;cisgender;Clinical Skills;Collaborations;Data;Dementia;dementia burden;dementia risk;Development;Diagnosis;Electronic Health Record;Endocrinology;experience;Faculty Workshop;Grant;Health;Individual;Link;meetings;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Myocardial Infarction;Oral;Outcome;parent grant;Persons;Population;predictive modeling;Prevention;Preventive care;programs;Research;Research Personnel;Resources;Risk Assessment;Risk Factors;Scientist;Services;Sexual and Gender Minorities;skills;Stroke;symposium;transgender;Universities;Work;Writing

PROJECT_TITLE: Assessing the burden of dementia in transgender populations

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Diabetes;Nutrition

ORG_CITY: MOSCOW

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE This research has broad public health relevance as it is focused on reducing the risk of health complications for diabetic Muslims who fast during Ramadan. Understanding the healthcare needs of fasting diabetic Muslims and dietitians’ current capacity to meet these needs will be the basis for the development of training programs and educational resources to improve the provision of culturally competent care for diabetic Muslims.

PI_NAMEs: LANE, GINNY  (contact)

PROGRAM_OFFICER_NAME: GARTRELL, KYUNGSOOK

PROJECT_TERMS: Accreditation;Address;Adult;Attitude;Awareness;Belief;Brain;Caring;Communities;Community Networks;Complications of Diabetes Mellitus;Country;Cross-Sectional Studies;cultural competence;Data;Dedications;design;Development;Diabetes Mellitus;diabetic;Diet;Dietary Practices;dietary requirement;Dietetics;Dietitian;disability;education resources;Equity;expectation;experience;Faith;Fasting;Focus Groups;Food;food security;Goals;graduate student;Grant;Guidelines;Health;health care service;Health Promotion;Health Services Accessibility;Healthcare;Hemorrhage;Hour;Hypoglycemia;Immigrant;improved;Individual;Interview;Knowledge;life span;Mentorship;Methods;Mission;Muslim population group;Myocardial Infarction;nutrition;Nutritional;Outcome;Participant;Patients;Perception;Persons;Pharmaceutical Preparations;Play;Population;Population Heterogeneity;Process;public health relevance;recruit;Religion;Research;Research Design;Risk;Risk Reduction;Role;skills;Structure;Suggestion;Surveys;Technical Expertise;Training and Education;Training Programs;Type 2 diabetic;Unconscious State;undergraduate student;Underrepresented Populations;United States National Institutes of Health

PROJECT_TITLE: Enhancing culturally safe healthcare for fasting Muslims during Ramadan


NIH_SPENDING_CATS: Cancer;Clinical Research;Pediatric

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Chicago EYES on Cancer is an innovative two-year program for high school students, college students, and high school science teachers from across Chicago’s diverse communities, engaging them in cutting-edge cancer research, science education, and biomedical career exploration. This proposal details plans to build on the success of EYES via strong integration within the University of Chicago’s scientific community; strategic partnerships with the city’s educational and cultural institutions; and the dedication of an experienced and passionate leadership team. In these ways, EYES will continue to empower the city’s talented youth to pursue careers in biomedicine, supporting NCI’s mission to build a diverse cancer workforce, advance scientific knowledge, and help all people live longer, healthier lives.

PI_NAMEs: DOLAN, MARY EILEEN (contact);MEKINDA, MEGAN

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;anti-cancer research;Awareness;Cancer Science;career;Career Choice;career development;Career Exploration;career networking;Caring;Chicago;Cities;Communication;Communities;Competence;Complement;Comprehensive Cancer Center;Data;Dedications;Doctor of Philosophy;Education;education research;Educational workshop;Emotional;Employment Opportunities;empowerment;Enrollment;Evaluation;experience;Faculty;Family;Funding;Goals;graduate student;Grant;Growth;high school;high school program;High School Student;Human Resources;improved;Individual;Industry;innovation;insight;Institution;interest;Interview;Knowledge;Lead;Leadership;Learning;LinkedIn;Literature;Malignant Neoplasms;Medicine;member;Mentors;Mentorship;Minor;Mission;National Cancer Institute;outreach;Participant;Persons;Population;Postdoctoral Fellow;programs;Research;research facility;Research Personnel;Resources;responsible research conduct;role model;Schools;Science;science education;science museum;science teacher;Scientific Advances and Accomplishments;Secure;skill acquisition;skills;Social Network;Strategic Planning;Students;success;support network;Surveys;Talents;teacher;Techniques;Television;Time;Training;Training and Education;Training Programs;underserved community;Universities;university student;Work;Youth

PROJECT_TITLE: Chicago EYES (Educators and Youth Enjoy Science) on Cancer {2024}

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Digestive Diseases;Disability Research;Neurosciences;Rehabilitation

ORG_CITY: RICHARDSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE Recurrent laryngeal nerve (RLN) injury causes communication and swallowing deficits and impacts health, work productivity, and quality of life. Enhanced central neuromodulation via electrical stimulation to the vagus nerve, paired with a motor-specific behavior, may help restore motor function to the muscles of the larynx. Understanding the role of enhanced central neuroplasticity on functional and neuroplastic outcomes in the context of RLN injury chronicity and laterality in an animal model will provide a springboard for novel treatment approaches for laryngeal motor impairments after RLN injury.

PI_NAMEs: SHEMBEL, ADRIANNA  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Acute;adduct;Affect;Anastomosis - action;Animal Model;Animals;aspirate;Aspiration Pneumonia;Axon;Basal Nucleus of Meynert;Behavior;Behavioral;Bilateral;Bolus Infusion;Brain;Central Nervous System;Chronic;Communication;Complex;Contralateral;Data;Deglutition;Deglutition Disorders;Economic Burden;Electric Stimulation;esophagus pressure;experimental group;experimental study;Flexor;Forelimb;Functional disorder;functional restoration;Goals;Handedness;Health;Impairment;improved;Injections;Injury;Ipsilateral;Laryngeal muscle structure;Laryngoscopy;Larynx;Lead;locus ceruleus structure;Maps;Medial;Mediating;Modeling;Morphology;Motion;Motor;motor control;Motor Cortex;motor deficit;Motor Endplate;motor impairment;Motor Neurons;Motor Pathways;motor recovery;motor rehabilitation;Movement;Muscle;Muscle function;Muscle Tonus;Nature;Nerve;nerve injury;neural circuit;Neuromodulator;Neuromuscular Junction;Neuronal Plasticity;neuroregulation;novel;nucleus ambiguus;Operative Surgical Procedures;Outcome;Outcome Measure;Paralysed;Pathway interactions;Patients;Peripheral nerve injury;Pharyngeal structure;pressure;primary outcome;Procedures;Productivity;psychosocial;Quality of life;Rattus;Recovery;Recurrent Laryngeal Nerve;reinnervation;restoration;Risk;Role;Safety;secondary outcome;Side;simulation;social;Structure of ulnar nerve;Symptoms;Synapses;Synkinesis;Testing;Therapeutic;Training;Ultrasonics;vagus nerve stimulation;Vagus nerve structure;vocal cord;vocalization;Vocation;Voice;Work

PROJECT_TITLE: Central modulation-paired motor rehabilitation for recurrent laryngeal nerve injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE SARS-CoV-2 is responsible for current pandemic and the development of intervention strategies against coronaviruses with pandemic potential is most critical. This proposal seeks to develop novel vaccine immunogens and vaccination strategies that can induce pan-betacoronavirus broadly neutralizing antibody responses by vaccination. A robust and durable vaccine against coronaviruses will be a powerful intervention to control and eventually eliminate SARS-CoV-2 infections and potential emerging coronaviruses and thus the application is highly relevant to human health and welfare.

PI_NAMEs: ANDRABI, RAIEES AHMAD (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;Address;Affinity;Animal Model;Animals;Antibodies;antibody engineering;Antibody Response;Antigens;Applications Grants;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;betacoronavirus;betacoronavirus vaccine;Binding;Coronavirus;Coronavirus Infections;coronavirus pandemic;Coronavirus spike protein;coronavirus vaccine;COVID-19;current pandemic;design;Development;Directed Molecular Evolution;Elements;Engineering;Epitopes;Future;future outbreak;Genetic;Germ Cells;Germ Lines;Goals;Health;Human;human coronavirus;Immune response;In Vitro;in vivo;Intervention;Knowledge;Methods;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;nanoparticle;neutralizing antibody;novel;novel coronavirus;novel vaccines;outbreak control;pandemic coronavirus;pandemic disease;pandemic potential;pandemic preparedness;Peptides;pre-clinical;Preventive vaccine;Property;protective efficacy;Protein Engineering;Proteins;prototype;rational design;Reproducibility;research clinical testing;respiratory;Sarbecovirus;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 variant;Site;stem;Testing;therapy development;tool;Translating;transmission process;universal coronavirus vaccine;Vaccination;vaccination protocol;vaccination strategy;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;vaccine platform;vaccine strategy;vaccine trial;vaccine-induced antibodies;Vaccines;variants of concern;Virus;welfare;Work;Zoonoses

PROJECT_TITLE: Development of pan-betacoronavirus vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE There is a critical need to identify modifiable factors that promote cognitive reserve, slow cognitive decline, and reduce risk for Alzheimer’s disease and related dementias (ADRD) among older adults who lack formal education. Using longitudinal data from a nationally representative study of older adults in India, we will identify the roles of life course employment, social relationships, and social engagement in cognitive reserve, cognitive change, and ADRD risk, overall and according to access to early-life formal education. Our results will advance scientific theory on resilience to aging-related brain pathology in the absence of education and support the identification of intervention targets to reduce the global ADRD burden for diverse older populations.

PI_NAMEs: KOBAYASHI, LINDSAY C (contact);LEE, JINKOOK

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Adult;aged;Aging;aging related;Alzheimer's disease related dementia;Biological Markers;Blood;Brain Pathology;Clinical Data;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive reserve;cognitive testing;Collaborations;Country;Data;Dementia;dementia burden;dementia risk;Development;Diagnostic;Education;Educational Background;Employment;experience;Funding;Future;Gender;Goals;Impaired cognition;Incidence;Income;India;Inequity;innovation;Intervention;Interview;Knowledge;Labor Forces;late life;Leadership;Life;Life Cycle Stages;Longitudinal Studies;low and middle-income countries;Magnetic Resonance Imaging;Measures;men;Nature;novel;Occupations;older adult;Older Population;Outcome Measure;Pathway interactions;Persons;Pilot Projects;Population;Population Heterogeneity;Predisposition;prevent;protective factors;Protocols documentation;Recording of previous events;Research;Research Personnel;resilience;resilience in aging;Resources;Risk Reduction;Role;Sampling;Scientific Advances and Accomplishments;skills;social;social engagement;social relationships;Source;theories;Variant;Woman

PROJECT_TITLE: Non-educational sources of later-life cognitive reserve and resilience among older adults with and without formal education in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-L (A2)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project narrative: Many glaucoma patients experience continued vision loss despite maximally reduced intraocular pressure, indicating that additional factors contribute to the pathology of the disease. Our preliminary studies have indicated that the T-cell population of some patients exhibits a markedly pro-inflammatory skew and that the removal of T-cells protects vision in animal models of the disease. The goal of this project is to identify which T-cell population is active in this process and to elucidate the mechanisms of T-cell mediated damage to the retina in glaucoma.

PI_NAMEs: KUEHN, MARKUS H. (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Age;Alleles;Animal Disease Models;Animal Model;Animals;axonal degeneration;B-Lymphocytes;Biological Assay;Blindness;Blood specimen;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Death;Cell Fraction;cell injury;cell mediated immune response;cell type;Cessation of life;Chronic;Clinical Research;comparison control;Cytoprotection;cytotoxic;Data;design;Development;Disease;Excision;Exhibits;expectation;experience;Extravasation;Eye;Eye diseases;Frequencies;Functional disorder;Future;Gene Deletion;Gene Expression Profile;Genetic Transcription;Glaucoma;Goals;Human;human disease;Immune response;Immunohistochemistry;immunomodulatory therapies;immunoregulation;improved;in vitro Assay;in vivo;Individual;Inflammation;Inflammatory;innovation;insight;Knock-out;Knockout Mice;lymph nodes;Mature T-Lymphocyte;Mediating;Medical;Methods;Modeling;Molecular;mouse model;Mus;myocilin;normotensive;novel;novel therapeutic intervention;Pathology;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Physiologic Intraocular Pressure;Population;preservation;Primary Open Angle Glaucoma;Process;Production;Publishing;Quality of life;Retina;retinal damage;Retinal Ganglion Cells;Rodent Model;Role;single nucleus RNA-sequencing;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;TNF gene;Transgenic Mice;translational impact;Treatment Protocols;Vision;Work

PROJECT_TITLE: T-cell mediated RGC damage in glaucoma Diversity Initiative Supplement

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Deficits in executive functioning (EF) disproportionately impact children living in poverty and increase risk for psychopathology, particularly disruptive behavior disorders. This randomized clinical trial seeks to determine whether childhood EF, assessed across neural and behavioral units of analysis, is an experimental therapeutic target that can be directly modified through caregiver participation in the Chicago Parent Program (CPP), if increases in EF predict reduced disruptive behavior trajectories in low-income children over a short-term follow-up period, and identify which CPP-driven parenting skill improvements are the most influential in modifying EF. This work will contribute new knowledge as to whether a cost-efficient parenting intervention, developed for and with low-income families raising young children in poverty, can modify EF, a neural- behavioral mechanism implicated in risk for childhood disruptive behavior problems.

PI_NAMEs: SUOR, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: 5 year old;Address;Adolescence;affective neuroscience;Aftercare;Age;Area;Award;Behavior;Behavioral;Behavioral Mechanisms;Brain;brain behavior;career;career development;Caregivers;Chicago;Child;Child Rearing;Childhood;Chronic;clinical translation;Clinical Trials;cognitive control;cognitive performance;cognitive process;cognitive task;collaborative environment;community based research;Community Mental Health Services;comparison control;Conduct Disorder;Control Groups;cost efficient;Data;design;Development;Diagnostic;diagnostic criteria;Discipline;Disruptive Behavior Disorder;dissemination science;early childhood;Electroencephalography;Eligibility Determination;Enrollment;Ensure;Etiology;Evaluation;Executive Dysfunction;executive function;experience;Family;follow-up;Goals;health disparity;Health Services Research;Illinois;Impairment;implementation science;improved;indexing;Individual Differences;Influentials;Informal Social Control;Interview;Investigational Therapies;Knowledge;life span;Link;Low income;lower income families;Measures;Mediating;Medicaid eligibility;Mental disorders;Mental Health;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Modification;Monitor;National Institute of Mental Health;neural;Neuronal Plasticity;neurophysiology;novel;Nursery Schools;Oppositional Defiant Disorder;parental influence;parenting intervention;Parents;Phase;Poverty;Prediction of Response to Therapy;prevent;Prevention program;preventive intervention;Problem behavior;programs;protective effect;Psychiatry;Psychopathology;psychosocial;Publishing;Randomized;randomized, clinical trials;Recording of previous events;recruit;Reporting;Research;Research Domain Criteria;Risk;Sampling;scaffold;Scientist;skills;Stress;Surveys;Testing;theories;therapeutic target;Time;Training;Universities;Work;Youth

PROJECT_TITLE: Improving Brain-Behavior Markers of Preschool Executive Function through aGroup-Based Parenting Intervention for Low-Income Families


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE A key feature of familial dementia syndromes is the acceleration of processes that normally take most of a lifetime to occur, with devastating consequences. We will harness well-defined and vetted molecular systems developed in our lab to define how dementia peptides found in patients cause the observed accelerations. Understanding the underlying molecular mechanisms can provide novel paths to disrupt the processes that lead to accelerated formation of amyloid plaques and fibrillar tangles that are the hallmarks of Alzheimer’s disease and related dementias.

PI_NAMEs: KLEVIT, RACHEL E (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acceleration;Age;age related;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;amyloid formation;Appearance;Binding;Biological Assay;Brain;British;Cataract;causal variant;Client;crosslink;Crystallins;Dementia;Development;early onset;Event;Familial Dementias;Functional disorder;Genes;Genetic;Heat shock proteins;holistic approach;HSPB1 gene;Individual;inhibitor;Integral Membrane Protein;intermolecular interaction;Investigation;lens;lens transparency;Maps;Mass Spectrum Analysis;Modeling;Molecular;Molecular Chaperones;mutant;Mutation;Neurofibrillary Tangles;Neurons;novel;parent grant;Pathology;Patients;Peptides;Physiological;Process;protein aggregation;Protein Inhibition;Proteins;Proteolytic Processing;Reagent;Reporting;Senile Plaques;Symptoms;Syndrome;System;tau Proteins

PROJECT_TITLE: A Holistic Approach to Understanding Small Heat Shock Protein Mechanism

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Orphan Drug;Pediatric;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PHR: NARRATIVE The University of Michigan Consortium partners transplant teams from the two leading cancer centers—the University of Michigan (U-M) and Karmanos Cancer Institute (KCI)—and the two leading pediatric hospitals in the State of Michigan. The U-M Consortium will emphasize strategies to reduce the toxicity of transplants for patients with non-malignant blood disorders, including patients with sickle cell anemia and immunologic disorders. This study proposes administering a novel oral agent (Vorinostat) to patients during the initial month of transplant in an attempt to lessen organ toxicity, reduce the incidence and severity of graft versus host disease and improve overall survival in this patient population.

PI_NAMEs: CHOI, SUNG WON ;YANIK, GREGORY A (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Graft Versus Host Disease;Adult;Area;biobank;Biology;Bone Marrow Transplantation;Cancer Center;Cells;Cessation of life;Childhood;Chimerism;chronic graft versus host disease;Clinical;Clinical Trials;Clinical Trials Network;conditioning;Disease;Disease-Free Survival;early phase clinical trial;Enrollment;Epigenetic Process;Event;experience;Failure;Foundations;Funding;graft failure;Graft Rejection;graft vs host disease;Grant;HDAC4 gene;Hematological Disease;Hematologist;Hematopoietic stem cells;Hemoglobinopathies;Histone Deacetylase Inhibitor;Immune;Immune System Diseases;Immunosuppression;improved;Incidence;Inherited;insight;interest;Malignant Neoplasms;Marrow;Michigan;Multi-Institutional Clinical Trial;multi-site trial;Multicenter Studies;Non-Malignant;novel;novel therapeutics;Oral;Organ;organizational structure;participant enrollment;Pathway interactions;patient population;Patients;Pediatric Hospitals;pediatric patients;Pediatrics;Physicians;pre-clinical;preclinical study;prevent;programs;Regimen;Research;Research Personnel;Research Proposals;Role;Scientist;secondary endpoint;Severities;Siblings;Sickle Cell Anemia;Site;Source;Special Population;success;Toxic effect;Translating;Translations;Transplant Recipients;Transplantation;United States National Institutes of Health;Universities;University Hospitals;urban area;Vorinostat;Work

PROJECT_TITLE: BMT Core- University of Michigan Core Clinical Consortium for the BMT Clinical Trials Network (BMT CTN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative Complex cognitive behaviors are thought to be supported by distributed activity across the brain, but we do not know which exact activity patterns cause specific components of cognitive behavior. This knowledge gap exists partly because most current perturbation methods target single or few brain regions at a time, and do not account for off-target changes in neural activity. Here, we proposed to develop new methods to fill this gap, using simultaneous neural recordings and large-scale spatially stochastic optogenetic perturbation across the mouse dorsal cortex, combined with computational methods, to infer how distributed neural processes generate cognitive behavior.

PI_NAMEs: PINTO, LUCAS  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Address;Area;Behavior;Behavior Control;Behavioral;Brain;Brain region;Cerebral cortex;Cognition;Cognitive;cognitive process;cognitive task;college;Communication;Communities;Complex;Computer software;computerized tools;Computing Methodologies;cortex mapping;Custom;Data;Decision Making;density;design;Devices;digital;Disparate;Dorsal;Electrical Engineering;Electrophysiology (science);Environment;Etiology;expectation;Experimental Designs;experimental study;extracellular;flexibility;Future;graphical user interface;Head;Image;inhibitory neuron;Intuition;invention;Knowledge;Laboratories;Lasers;Light;Link;Maps;Mental Processes;Methodology;Methods;model organism;monocular;Movement;Mus;Nature;neural;neuromechanism;Neurons;Neurosciences;novel strategies;open source;Optics;optogenetics;Pattern;Performance;Process;Pythons;receptive field;Resolution;Running;Sensory;Silicon;spatiotemporal;stem;Stimulus;System;Time;Translating;two-photon;Vacuum;virtual reality;Visual Cortex;Visual Fields;Walking;Work

PROJECT_TITLE: Inferring causality with spatiotemporally stochastic optogenetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-D (55)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: This work will greatly improve our understanding of the effects of the neonicotinoid insecticide known as imidacloprid on the ovary and female fertility. This work is critical for helping us determine whether imidacloprid poses a female reproductive health hazard.

PI_NAMEs: FLAWS, JODI A. (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Adult;Adult women;Affect;Affinity;Agonist;Agriculture;Agrochemicals;Antral;Apoptotic;Area;base;Binding;Cessation of life;Chronic;Chronic Disease;companion animal;Consumption;cost efficient;Coupled;Data;drinking water;Environment;Estradiol;experimental study;Exposure to;Female;female fertility;Fertility;Fleas;folliculogenesis;Food Contamination;Goals;Growth;Health;Health Hazards;Home;Hour;Human;imidacloprid;improved;In Vitro;in vivo;Industry;Infertility;Ingestion;Insecta;Insecticides;Link;Liver;Mammals;Mastication;Molecular;mouse model;Mus;Nervous System;Neurotoxins;Nicotine;Nicotinic Receptors;novel;Ovarian;Ovarian Follicle;Ovary;ovotoxicity;Pathway Analysis;Pathway interactions;Pesticides;pet animal;Pharmacologic Substance;Privatization;Production;Public Health;Regulation;Reproduction;Research;Rupture;Sales;Series;small molecule;Source;Steroid biosynthesis;subfertility;sucking;System;Testing;Ticks;Time;toxicant;transcriptomics;Treatment Cost;Water;women's reproductive health;Work

PROJECT_TITLE: Neonicotinoid insecticides and female reproduction

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: CHEMISTRY

PHR: The insertion of oxygen atoms into molecules by non-heme oxygenase enzymes is involved in numerous biological processes, and therefore greatly impacts human health. These diverse enzymes share a common active site but it is unclear how they achieve such a wide range of functions. A better understanding of the active site structure-function relationship, which we will achieve using accurate model systems, is expected to illuminate fundamental chemistry that will help explain the importance and versatility of the non-heme oxygenase active sites. Thus, the research aligns with mission of NIGMS to better understand the fundamental biological processes of living organisms.

PI_NAMEs: NGUYEN, ANDY I (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Active Sites;Address;Affect;Amino Acids;analog;Binding;Binding Sites;Biological Models;Biological Process;Biomimetics;carboxylate;catalyst;Chemistry;climate change;design;Environment;enzyme mechanism;Enzymes;Face;Health;Human;Hydrogen Bonding;Laboratories;Ligands;Metabolism;Metals;Methane hydroxylase;Mission;Modeling;Mononuclear;National Institute of General Medical Sciences;Natural Products;Organism;Outcomes Research;Oxygen;Oxygenases;Particulate;Peptide Synthesis;Peptides;Pharmacologic Substance;Porosity;Property;Proteins;remediation;Research;Site;Structure;Structure-Activity Relationship;System;Therapeutic;Water;X-Ray Crystallography

PROJECT_TITLE: In crystallo biomimetic oxygenase chemistry within peptidic frameworks

STUDY_SECTION: MRAE

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - E Study Section[MRAE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Sustained attention, the ability to focus on an activity or stimulus over time, is significantly impaired in many neuropsychiatric disorders. In this application we optimize key parameters in a touchscreen-based continuous performance test in mice to validate electrophysiological correlates of behavioral performance as putative translational biomarkers and provide mechanistic insight about the circuits underlying this behavior. This proposal is relevant to the part of the NIH mission that pertains to the translation of basic mechanisms underlying mental illnesses into innovative treatments.

PI_NAMEs: CARR, GREGORY V (contact);MARTINOWICH, KERI

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: addiction liability;Affect;Amphetamines;Anatomy;Anterior;Arousal;Attention;Attentional deficit;Behavior;Behavior Control;behavior measurement;Behavioral;Biological Assay;Biological Markers;biomarker identification;Brain Diseases;cingulate cortex;Cognitive;Conflict (Psychology);Cues;Data;design;Detection;Development;Dorsal;early screening;Electroencephalography;Electrophysiology (science);Enhancers;Etiology;experimental study;Feedback;Frequencies;Functional Magnetic Resonance Imaging;functional outcomes;Goals;Human;Impairment;improved;in vivo;innovation;insight;Length;Link;Literature;locus ceruleus structure;Machine Learning;Measures;Mental disorders;Mission;model organism;Mus;Nature;neural;neural circuit;neural patterning;Neurobiology;Neurons;neurophysiology;neuropsychiatric disorder;neurotransmission;nonhuman primate;novel therapeutics;Patients;Performance;performance tests;Phase;pre-clinical;Process;Production;Protocols documentation;psychostimulant;Quality of life;Rattus;Reaction Time;recruit;response;Rodent;Role;side effect;Signal Transduction;Stimulus;Structure;sustained attention;Symptoms;Testing;therapy development;Time;touchscreen;translational study;Translations;United States National Institutes of Health;Validation;vigilance

PROJECT_TITLE: Validation of electrophysiological biomarkers associated with performance in a preclinical assay of sustained attention

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Aging;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: NARRATIVE This application proposes a newly instantiated Coordinating Center for Primate Aging Research (CCPAR) to coordinate the work of a broad array of specialists across gerosciences and facilitate integration of data from NIA-funded research programs across sites, endpoints, approaches to measurement, and species. A major focus of the supported grants will be comparative studies across multiple nonhuman primate (NHP) species with the goal of illuminating determinants of lifespan and healthspan in humans. This proposal is aimed at coordinating multi-species data that identify intrinsic and extrinsic factors of age resilience that which could be leveraged to slow biological aging in humans and lead individuals to live longer, better lives with fewer age-associated comorbidities.

PI_NAMEs: MORRISON, JOHN H;RAPPAPORT, JAY  (contact);ROGERS, JEFFREY A.

PROGRAM_OFFICER_NAME: NGUYEN, CAROL VINTON

PROJECT_TERMS: Advisory Committees;Age Factors;age related;Age related comorbidities;aged;Aging;aging related;Animals;Behavioral;Biological Aging;California;Catalogs;Charge;Clinical Research;college;Communication;Communities;Comparative Study;Data;data harmonization;data integration;data interoperability;Data Pooling;Data Set;data sharing;Data Sources;Databases;Dedications;design;Development;Discipline;Educational workshop;Ethics;Event;Experimental Designs;Funding;Future;Genetic;Genomics;Geroscience;Goals;Grant;healthspan;Human;improved;Individual;informatics tool;Infrastructure;Institution;interoperability;Intervention;Intervention Studies;Lead;Life;life span;Link;Liquid substance;Longevity;Macaca mulatta;Maintenance;Measurement;Mediating;Medicine;meetings;Methodology;Methods;multiple data types;nonhuman primate;novel;Outcome;outreach;Paper;Phase;Phenotype;Pilot Projects;Policies;Primates;programs;Qualifying;Research;Research Design;Research Personnel;resilience;Resources;Sampling;Scientist;Series;Site;Specialist;species difference;Specimen;synergism;System;Tissues;Training;Translations;United States National Institutes of Health;web portal;web site;webinar;Work;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M2)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Liver Disease and Cirrhosis;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity

ORG_CITY: QUEENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: ST. JOHN'S UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease with increasing incidence rates worldwide; but no FDA-approved treatments are available currently. Absence of Lipocalin Prostaglandin D2 Synthase (L-PGDS) developed fatty liver disease accompanied with insulin resistance and weight gain in mice; however, the precise role of L-PGDS in NAFLD is unknown. Research in this SuRE First (R16) proposal will investigate the molecular mechanisms of signaling by L-PGDS and its metabolite PGD2 that has potential for the discovery of novel NAFLD therapeutic targets.

PI_NAMEs: KUMAR, SUNIL  (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Address;Affect;Agonist;allergic response;antagonist;Apolipoprotein E;Biology;Cells;chronic liver disease;comparison control;Control Groups;curative treatments;Data;db/db mouse;Dedications;Development;Diabetes Mellitus;Disease;disease phenotype;Dopamine D2 Receptor;Etiology;Exhibits;Fat-Restricted Diet;fatty acid oxidation;fatty liver disease;FDA approved;Functional disorder;Future;G-Protein-Coupled Receptors;Gene Expression;glucose metabolism;Glycolysis;Glycoproteins;Goals;graduate student;Hepatic;HepG2;High Fat Diet;human disease;Immune response;In Vitro;in vitro Model;Incidence;Individual;innovation;Insulin;Insulin Resistance;insulin signaling;Isomerism;Knockout Mice;Knowledge;Learning;lifestyle intervention;Link;lipid biosynthesis;lipid metabolism;Lipids;Liver;liver injury;Metabolic;Metabolic Diseases;metabolomics;Modeling;Molecular;mRNA Expression;Mus;Names;new therapeutic target;non-alcoholic fatty liver disease;novel;novel therapeutic intervention;novel therapeutics;Obesity;overexpression;Pathogenesis;Pathway interactions;Patients;pharmacologic;Pharmacotherapy;Physiological;Physiology;Play;Population;prevent;Prostaglandin D2;Prostaglandin-Endoperoxide Synthase;protein expression;Proteins;receptor;Regulation;Research;Role;Signal Pathway;Signal Transduction;Testing;Therapeutic;therapeutic target;transcriptomics;Triglycerides;undergraduate research experience;Universities;Weight Gain;Work

PROJECT_TITLE: Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-T (SF)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE This educational research program targets high school students from a rural, lower socioeconomic status area to promote a more diverse future biomedical workforce. Faculty-mentored research projects, development of a training curriculum, bi-directional feedback with community stakeholders, undergraduate mentors, community education, and integration of cancer disparities throughout all aspects of the program are highlights of the proposal. Program evaluation, including tracking students 15 years to determine future career pursuits, is emphasized.

PI_NAMEs: GILLESPIE, THERESA W (contact);MARCUS, ADAM I.

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Affect;African American population;anti-cancer research;Area;Biomedical Research;Black Populations;cancer health disparity;Cancer Science;career;career development;Categories;Characteristics;Clinical Trials;college;Communities;community engagement;Community Health Education;Community Outreach;community partners;community setting;County;curriculum development;Data;demographics;Development;disability;Disparity;disparity reduction;Diverse Workforce;Drops;Education;education research;Educational Curriculum;eleventh grade;Enrollment;Ensure;Environment;Epidemiology;ethnic diversity;ethnic minority;ethnic minority population;experience;faculty mentor;Family;Feedback;Female;Future;Goals;health equity;Hematology;high school;High School Student;higher education;Hispanic Populations;Individual;interest;Intervention;Latino Population;Link;low socioeconomic status;Malignant Neoplasms;Mathematics;Medical Oncology;Medically Underserved Area;Mentors;minority student;Motivation;National Cancer Institute;novel;Outcome;outcome disparities;Outcome Measure;outreach;Participant;Persons;Population;Poverty;primary outcome;Process;Program Evaluation;programs;racial diversity;racial minority;racial minority population;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;Risk;Rural;rural area;rural dwellers;rural underrepresented;rural underserved;Schools;Science;science education;Site;skills;Socioeconomic Status;STEM career;STEM field;student participation;Students;suburb;teacher;Testing;Time;Training;Training Programs;training project;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Georgia Science Education Initiative NCI YES (GA-YES)


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Primary Health Care

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Heavy workload contributes to burnout and job dissatisfaction among nurses. Computational modeling of nursing workflow using a scalable platform is an important first step toward testing interventions to reduce workload-driven burnout. Understanding workload contributes to health equity efforts by identifying patient populations most likely to experience inadequate care due to inconsistencies in nurse workload and staffing.

PI_NAMEs: TIASE, VICTORIA LYNN (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: Area;artificial intelligence model;Behavior monitoring;burnout;Care given by nurses;career;career development;Caring;Classification;clinical care;Cluster Analysis;community clinic;Complex;Computer Models;Consumption;contextual factors;cost;Country;Data;Data Reporting;Data Science;Data Sources;deep learning algorithm;Discipline of Nursing;Doctor of Philosophy;Documentation;education resources;electronic health data;Electronic Health Record;Ensure;experience;Future;Goals;Grant;health equity;Health Policy;Healthcare Systems;high risk;improved;Informatics;Information Retrieval;innovation;Inpatients;insight;Institution;Interdisciplinary Study;Intervention;Knowledge;Leadership;Link;Measurement;Measures;Mentored Research Scientist Development Award;Mentors;Modeling;Monitor;multidisciplinary;neural network architecture;Nurses;Nursing Informatics;Nursing Models;Occupations;Outcome;Outpatients;patient population;Patient Self-Report;Pattern;Personal Satisfaction;Phenotype;Policies;Positioning Attribute;Primary Care;professional atmosphere;Reduce health disparities;Registered nurse;Reporting;Reproducibility;Research;research and development;Research Personnel;Resources;Science;skills;Solid;statistics;Structure;success;Surveys;System;Techniques;Testing;Time;Time and Motion Studies;Training;Training and Education;Translational Research;trend;unsupervised learning;Work;Workload;Writing

PROJECT_TITLE: AI modeling of nursing workload to understand burnout

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Inflammation in the brain results in the accumulation of excess waste, fluid, and immune cells which require mechanisms of drainage and coordination with the peripheral immune system. Failure to do so may result in the exacerbation of a variety of brain diseases like Alzheimer’s, traumatic brain injury, Parkinson’s, glioblastoma, multiple sclerosis and stroke. Our lab discovered that meningeal lymphatic vessels at the cribriform plate near the front of the brain are highly dynamic regulators of neuroinflammation and we seek to understand if local crosstalk between these lymphatic vessels and migratory dendritic cells controls disease related immune response in the brain. Pharmacological manipulation of the cross-talk between dendritic cells and cribriform lymphatic endothelial cells may have potential therapeutic value for diseases of the central nervous system.

PI_NAMEs: FABRY, ZSUZSANNA  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adhesions;Alzheimer's Disease;Antigen Presentation;Antigen-Presenting Cells;Antigens;Area;Binding;Brain;Brain Diseases;Brain Drains;brain parenchyma;Cell Communication;cell motility;cell type;Cells;Central Nervous System;Central Nervous System Diseases;CNS autoimmunity;Communication;confocal imaging;cribriform plate;Cues;Data;Dendritic Cell Pathway;Dendritic Cells;Disease;Disease Progression;disorder control;Drainage procedure;draining lymph node;Endothelial Cells;Failure;Flow Cytometry;Fluid Balance;Foundations;Gene Expression;Genomics;Glioblastoma;Growth;Homeostasis;Immune;Immune response;Immune system;Immunity;Immunologics;immunoregulation;In Situ;in vivo;Infiltration;Inflammation;Inflammatory;Intervention;Intravenous;ITGAX gene;Label;Leukocytes;Liquid substance;Location;Longitudinal Studies;lymph nodes;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic System;lymphatic vessel;Lymphoid;Maps;Measurable;Measures;Meningeal;Meningeal lymphatic system;migration;Multiple Sclerosis;Mus;Nature;Neuroimmune;neuroinflammation;neuropathology;Parents;Parkinson Disease;Pathway interactions;Peripheral;pharmacologic;Population;Positioning Attribute;prevent;programmed cell death ligand 1;Publishing;receptor;recruit;Regulation;Resolution;Role;Route;single-cell RNA sequencing;Stains;Stroke;Structure of choroid plexus;Subarachnoid Space;Synapses;T cell infiltration;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;timeline;Tissues;trafficking;Traumatic Brain Injury;Vascular Endothelial Growth Factor C;Visualization;wasting

PROJECT_TITLE: Regulation of Neuroinflammation by Meningeal Lymphatics


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Mild Cognitive Impairment (MCI) due to Alzheimer’s Disease (AD) is clinical stage of AD that precedes the onset of dementia, making it an opportune stage for both elucidating early consequences of AD on neural function as well as identifying novel neural markers of AD that are reliable and affordable. The present proposal will address both goals by using non-invasive electroencephalographic (EEG) measurements to characterize how processing of acoustics and linguistic features of continuous speech is affected in MCI with AD biomarkers, and to assess whether these measures can reliably distinguish participants with and without MCI. These results will represent an initial step towards the longer-term goals of developing more reliable measures of neural function in AD that can be used for tracking of disease progression and evaluation of the effects of novel clinical interventions.

PI_NAMEs: MESIK, JURAJ  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Age;age effect;age group;age related changes;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnostic;Alzheimer's disease risk;Alzheimer’s disease biomarker;Applications Grants;Attention;behavior prediction;Behavioral;behavioral outcome;Brain;Classification;Clinical;Cognition;Cognitive;cognitive control;Cognitive deficits;Collaborations;comparison control;Complement;Comprehension;Control Groups;coping mechanism;cost effective;Data;Data Set;Dementia;Disease Progression;early detection biomarkers;Early Diagnosis;Electroencephalography;Evaluation;Exhibits;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;Foundations;Future;Goals;healthy aging;hearing impairment;Human;Individual;innovation;insight;Intervention;Knowledge;language processing;Learning;life span;Linguistics;Link;Measurement;Measures;Methods;mild cognitive impairment;Modeling;Modernization;multitalker environment;neural;Neurobiology;Neurophysiology - biologic function;novel;older adult;Outcome;Parents;Participant;pathological aging;Patients;Performance;Persons;Physiological;Population;predictive modeling;Regression Analysis;Research;Resources;response;Response Latencies;Role;Sampling;semantic processing;Semantics;Short-Term Memory;Social Functioning;Speech;Speech Acoustics;Speech Perception;speech processing;speech recognition;Testing;Training;virtual;Work

PROJECT_TITLE: Effect of mild cognitive impairment and listening effort demands on cortical processing of narrative speech

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NAPERVILLE

ORG_NAME: NORTH CENTRAL COLLEGE

PHR: PROJECT NARRATIVE This proposal utilizes a rat model of extended-access oxycodone self-administration to study long-lasting changes in the brain underlying the time-dependent intensification (incubation) of oxycodone craving. We will expand upon the preliminary finding that subanesthetic ketamine doses given during withdrawal can reduce this incubation by examining the duration of ketamine’s effects, the timing and impact of single-dose administration regimen, and the potential anatomical loci and mechanisms that underlie these observations. Determining when, where, and how ketamine reduces incubation will help identify key targets aimed at reducing the neuroadaptations that occur during withdrawal.

PI_NAMEs: STEFANIK, MICHAEL THOMAS (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Abstinence;Acute;addiction;Alcohols;AMPA Receptors;Amygdaloid structure;Anatomy;Anesthetics;Animals;Behavioral;Brain;Characteristics;Cocaine;cocaine craving;cohort;craving;Cues;Data;Dose;drug craving;drug of abuse;Drug usage;Epidemic;Excitatory Synapse;Exhibits;Female;Glutamates;Goals;Half-Life;Heroin;Hippocampus;Hour;Human;Immunohistochemistry;Immunoprecipitation;Incubated;Infusion procedures;Injections;Ketamine;Label;Literature;male;Measures;Medial;Mediating;Modeling;neural;neuroadaptation;Neuronal Plasticity;Neurons;Neurosciences;NMDA receptor antagonist;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;opioid use;Oxycodone;oxycodone seeking;oxycodone self-administration;Pathologic;Pattern;Pharmaceutical Preparations;prescription opioid;prevent;Protein Biosynthesis;Proteins;psychostimulant;Puromycin;Rattus;Regimen;Relapse;relapse prevention;Research;reward circuitry;Rodent;Rodent Model;Role;Saline;Self Administration;Substance Use Disorder;substance use treatment;Synapses;synaptic function;Synaptic Transmission;synthetic opioid;Techniques;Testing;Therapeutic Effect;Therapeutic Intervention;Time;Tissues;Translations;transmission process;trend;undergraduate student;Viral;Western Blotting;Withdrawal

PROJECT_TITLE: Cellular and circuit adaptations contributing to the incubation of oxycodone craving


NIH_SPENDING_CATS: Clinical Research;Genetics;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE After years of development and refinement, large-scale genomic analysis has overcome many analytical challenges, enabling researchers like myself to harness its power as a tool to address additional major gaps in human health research. This proposal focuses on developing innovative, quantitative methods and enhancing existing resources that improve phenotype precision, harmonization, integration and accessibility, and their associations with markers of human health. In both the short and long-term, our approaches which refine and improve a diverse set of phenotypes for use by a broad set of investigators across many disciplines will aid in the identification of novel risk factors for human disease.

PI_NAMEs: COLE, JOANNE BURNETTE (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Applied Research;Area;Automobile Driving;biobank;Biological Models;Clinical;Clinical Trials;Colorado;Communities;Data;Data Set;Derivation procedure;Development;Discipline;Disease;empowerment;Environmental Impact;Environmental Risk Factor;Evolution;Genetic;Genetic Risk;Genomics;Goals;Growth;Health;health record;Heritability;Human;Human Characteristics;human disease;Human Genome;improved;Individual;innovation;insight;instrument;Intervention;Link;Mendelian randomization;Metabolic Diseases;method development;Methods;novel;Phenotype;Play;Positioning Attribute;Proxy;Research;Research Personnel;Resources;response;Risk Factors;Role;Scientific Advances and Accomplishments;Scientist;skills;Surveys;tool;trait;Universities;Vision;Work

PROJECT_TITLE: Genetics as a tool to improve phenotypes and associations with human disease

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Type 2 diabetes mellitus (T2DM) elevates the risk for life-threatening ventricular arrhythmias. We seek to utilize innovative and comprehensive approaches to examine altered T2DM-related leukotriene B4 mechanisms that promote adverse electrical remodeling and propensity for arrhythmias. We expect our mechanism-based studies to inform targeted therapies with significant implications for safer and more effective clinical interventions.

PI_NAMEs: AROMOLARAN, ADEMUYIWA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: 3-Dimensional;Acceleration;Action Potentials;Anabolism;Anti-Arrhythmia Agents;Arrhythmia;Biophysics;Cardiac;Cardiovascular system;Cavia;Clinical;clinical development;Clinical Research;Clinical Trials;Data;Defect;density;Development;Diabetes Mellitus;Diabetic mouse;Drug Targeting;Electrophysiology (science);Ethers;evidence base;expectation;experimental study;FDA approved;Fluorescence Resonance Energy Transfer;Future;Genes;Genetic;Goals;guinea pig model;Health;Heart;heart cell;Heart Rate;High Prevalence;Human;human model;Impairment;In Vitro;indium arsenide;Individual;Inflammatory;inhibitor;innovation;insight;Intervention;Ion Channel;Ischemia;Knock-out;Knowledge;Label;Leukotriene B4;Leukotrienes;Life;lipid mediator;LTB4R gene;Malignant - descriptor;Metabolic;Modeling;Molecular;mouse model;Muscle Cells;Myocardial dysfunction;Myocardium;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Optics;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;pre-clinical;prevent;Prevention;Proteins;Quantum Dots;Receptor Inhibition;Receptor Signaling;reconstruction;Regulation;Reperfusion Therapy;Reporting;Research;response;Risk;Risk Reduction;Science;Signal Transduction;sudden cardiac death;Surface;targeted treatment;Therapeutic;tool;Torsades de Pointes;trafficking;Ventricular;Ventricular Arrhythmia;Ventricular Remodeling

PROJECT_TITLE: Leukotriene B4 Regulation in Heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Autism;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: Project Narrative The goal of this project is to identify tandem repeat expansion mutations in high confidence autism-risk genes. We will elucidate the molecular mechanisms induced by these mutations and demonstrate the adverse effects on their host genes. Therefore, this project will profoundly impact our understanding of autism and will inform future biomarker and therapeutic strategy development.

PI_NAMEs: SZNAJDER, LUKASZ JAKUB (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Address;Adopted;Adverse effects;Affect;Area;autism spectrum disorder;Biological Markers;Candidate Disease Gene;Code;Communication;Complex;Computational Biology;design;Development;Disease;Environment;Etiology;Exons;falls;First Independent Research Support and Transition Awards;Future;Gene Expression;Genes;Genetic Enhancer Element;Genome;genome-wide;Genomics;Goals;Heritability;Human Genome;Induced Mutation;interest;Introns;Mediating;Molecular;Molecular Biology;mRNA Precursor;Mutation;National Institute of Mental Health;novel strategies;Pattern;Population;Productivity;Program Development;repetitive behavior;Reporting;Repression;Research;Research Priority;Risk;risk variant;RNA Processing;RNA Splicing;Sequence Analysis;Short Tandem Repeat;Site;Social Interaction;Statistical Data Interpretation;Strategic Planning;Tandem Repeat Sequences;Testing;Therapeutic;Transcript;Transcriptional Silencer Elements;Underrepresented Students;Untranslated RNA;Variant;virulence gene

PROJECT_TITLE: Identifying tandem repeat expansion-mediated mechanisms of autism-risk genes


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE There are no high throughput genetic methods to uncover mechanisms that drive chronic liver disease's progression to cirrhosis, limiting our ability to develop new therapies. Recently, we showed that some somatic mutations within diseased livers can exert adaptive effects that might benefit tissue health. Using new technologies developed in my lab, we propose to exploit somatic mosaicism as a genetic strategy to 1) identify adaptive genetic pathways and 2) understand how mutant clones expand within chronically damaged tissues, and potentially protect from disease.

PI_NAMEs: ZHU, HAO  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Age;Cells;Chronic;chronic liver disease;Cirrhosis;Complex;deep sequencing;Disease;Disease Pathway;Disease Progression;Etiology;experimental study;frontier;Gene Targeting;Genetic;genetic approach;Genetic Screening;Health;Human Genetics;in vivo;Injury;Island;Liver;Liver diseases;Malignant Neoplasms;Metabolic;Methods;mosaic;Mosaicism;mutant;Mutation;new technology;Nodule;novel therapeutics;Pathogenicity;Pathway interactions;prevent;Process;Somatic Mutation;Source;Steatohepatitis;Therapeutic;therapeutic target;tissue regeneration;Tissues;Visual

PROJECT_TITLE: Elucidating chronic liver disease pathways using somatic genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-S (M3)]


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The vast diversity in lifespans among organisms provides a remarkable natural experiment in which to explore the evolutionary innovations that have shaped the extensive variation of this phenotype. Non-human primates in particular represent a critical taxon for understanding the evolution of human lifespan due to their close phylogenetic proximity and broad range of lifespans. Here, we propose to characterize the somatic mutational landscape of aging across multiple tissues in primate species spanning 70 million years of evolution.

PI_NAMEs: CAGAN, ALEXANDER ;RAHBARI, RAHELEH ;SUDMANT, PETER HESHEDAHL (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Age;Age related pathologies;age-related disease;Aging;Agreement;Atlases;Automobile Driving;Biological Markers;Body Size;Callithrix;carcinogenesis;Cell Physiology;cell type;Cells;Clonal Expansion;Collection;comparative;Comparative Genomic Analysis;comparative genomics;Complement;Data;Data Analyses;deep sequencing;DNA Maintenance;DNA Repair Gene;Environmental Exposure;Evolution;Genes;Genetic;Genetic Determinism;genome sequencing;genome wide association study;Genomic approach;Genomic Instability;Genomics;Growth;hallmarks of aging;healthspan;Human;human data;human tissue;improved;Individual;innovation;insight;Intervention;Knowledge;Life;life history;life span;Link;Macaca;Maintenance;Mammals;Maps;Methods;Molecular;molecular phenotype;mutant;Mutation;Natural experiment;nonhuman primate;Normal Cell;novel;Nucleotides;Organism;Pan Genus;Papio;Pattern;Phenotype;Phylogenetic Analysis;Pongidae;Primates;Process;Recurrence;Research;Role;sex;Shapes;Somatic Mutation;Taxon;Technology;Tissues;tool;Trees;Variant

PROJECT_TITLE: Comparative analyses of somatic mutational processes in primates across lifespans

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (M1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_CITY: POMONA

ORG_NAME: CALIFORNIA STATE POLY U POMONA

PHR: PROJECT NARRATIVE  Toxoplasma gondii is a foodborne parasite that causes a highly prevalent infection and can lead to life- threatening disease in immunocompromised individuals and the developing fetus. Although it is well documented that immune cells called neutrophils infiltrate the site of acute T. gondii infection, there is limited understanding of how human neutrophils respond to T. gondii. This proposal will characterize and determine the importance of one neutrophil antimicrobial mechanisms in the immune response to T. gondii.

PI_NAMEs: LIMA, TATIANE S. (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acute;Acute Disease;acute infection;Affect;Alkalinization;antimicrobial;Award;Biochemical Reaction;Biological Assay;biological research;Blocking Antibodies;Blood donor;Brain;Bypass;career;Cell Line;Cells;Cessation of life;chronic infection;Communicable Diseases;Complement Receptor;congenital infection;CRISPR/Cas technology;crosslink;Data;Development;Disease;Environment;Event;experience;experimental study;extracellular;Fc Receptor;Fetal Development;foodborne;Genetic;graduate student;Health;Heart;HL60;Host Defense;Hour;Human;Immune;Immune Evasion;immune function;Immune response;Immune system;Immunity;Immunocompromised Host;Individual;Infection;inhibitor;Innate Immune Response;Invaded;Knock-out;knockout gene;Knowledge;Life;loss of function;Macrophage-1 Antigen;Measurement;Measures;Mediating;Mind;Mitochondria;Modeling;Molecular;monocyte;NADPH Oxidase;neglect;neutrophil;Neutrophil Infiltration;novel therapeutics;opsonin receptor;Organ;Parasite Control;Parasites;pathogen;Pathogenesis;Pathway interactions;Persons;Phagocytosis;Phagosomes;Plaque Assay;Play;Population;Prevention strategy;Process;Production;Reactive Oxygen Species;receptor;recruit;response;Role;Serum;Signal Pathway;Site;Source;Students;success;Testing;Therapeutic;Toxoplasma gondii;Toxoplasmosis;undergraduate student;United States;Vaccines;Vacuole

PROJECT_TITLE: Role of reactive oxygen species in controlling T. gondii acute infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SPJ-D (M1)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: The VA currently provides care for approximately 43,000 veterans with spinal cord injury (SCI), making it the single largest provider of care to patients with SCI. Up to three-quarters of individuals with SCI will sustain a fragility fracture in their lifetime. Half of patients who fracture will experience a serious medical complication. Fracture is a constant concern as seemingly innocuous activities such as joint range of motion exercises and transfers can result in fracture. SCI clinicians have neither evidence-based nor consensus guidelines for assessing skeletal health at the most fragile sites for patients with SCI. As a result, physicians must rely on experience and clinical judgment, rather than data, when recommending whether it is safe for a patient to participate in traditional rehabilitation activities, sports, or when using emerging technologies such as exoskeletons. The goal of the proposed study is to alleviate those shortcomings. Given the long history that VA has played in the care of individuals with SCI, we believe that the field will gain significantly from this research.

PI_NAMEs: KIRATLI, BEATRICE JENNY (contact)

PROJECT_TERMS: accurate diagnosis;active lifestyle;Address;Affect;Age Years;Age-Related Osteoporosis;Agreement;Area;Articular Range of Motion;Assessment tool;Awareness;bone;Bone Density;bone health;bone loss;Cardiovascular Diseases;care costs;care providers;Caring;Chromosome Fragile Sites;Chronic;Clinical;clinical implementation;Clinical Protocols;clinically relevant;Consensus;cost;Data;Databases;Development;Diabetes Mellitus;Direct Costs;Distal;Dual-Energy X-Ray Absorptiometry;Emerging Technologies;evidence base;exoskeleton;experience;Facilities and Administrative Costs;Female;Femur;Fracture;fracture risk;fragility fracture;Future;Gender;Goals;Guidelines;Health;Health Benefit;Health Personnel;hip bone;Hip region structure;Hospitalization;Incidence;inclusion criteria;Individual;Injury;Judgment;Knee;Knowledge;Lead;Leg;Leisures;Life Expectancy;life time cost;limb fracture;Location;Lower Extremity;Maintenance;male;Measurement;Measures;Medical Care Costs;medical complication;Monitor;Musculoskeletal;new technology;novel;Obesity;Osteoporosis;Paralysed;patient safety;Patients;Peripheral;Persons;Physicians;Play;Population;productivity loss;Protocols documentation;Range of motion exercise;Recommendation;Recording of previous events;Recreation;recruit;Recurrence;Reference Values;Rehabilitation therapy;Research;Resolution;Respiratory Disease;Risk;Risk Assessment;Risk Reduction;Scanning;Severities;Site;skeletal;Spinal cord injury;Sports;Standardization;Technology;Testing;tibia;Time;United States;Vertebral column;Veterans;Veterans Health Administration

PROJECT_TITLE: Assessing Bone Health after SCI: Establishing Evidence for a Clinical Protocol

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Veterans with a lower limb amputation typically use a rigid prosthetic socket that can result in impaired function and discomfort, which could increase the risks of osteoarthritis, leg/back pain, and diabetes/obesity. A prosthetic socket that allows adjustments in volume could alleviate these risks. Thus, we will determine the movements, forces, and comfort/satisfaction of female and male Veterans with below the knee and above the knee amputations using a conventional rigid socket and a novel socket with adjustable panels during walking. These outcomes could improve function and decrease secondary injury risk in Veterans, specifically female Veterans, with lower limb amputations by enhancing the mechanical coupling between a person and their prosthesis and reducing asymmetry. Decreasing residual limb movement within a socket could reduce skin irritation, which could lower abandonment of prostheses. A better fitting socket could improve comfort, which could ultimately improve rehabilitation, function, and quality of life for Veterans with amputations.

PI_NAMEs: GRABOWSKI, ALENA  (contact)

PROJECT_TERMS: 3D Print;Address;Affect;Amputation;Back;Back Pain;Biomechanics;Boa;carbon fiber;comorbidity;Compensation;Coupling;Custom;Degenerative polyarthritis;Diabetes Mellitus;Enrollment;Equilibrium;Evaluation;fall risk;Female;Femur;functional improvement;functional loss;Future;High Prevalence;Impairment;improved;Individual;Injury;Joints;kinematics;Kinetics;Knee;Knowledge;Leg;light weight;limb amputation;limb movement;Limb structure;Low Back Pain;Lower Extremity;male;manufacture;Manufacturer;Measures;Mechanics;Motion;Movement;Muscular Atrophy;novel;Nylons;Obesity;Outcome;Pain;Participant;Patients;Persons;Physical activity;Printing;Prosthesis;prosthesis fitting;prosthesis wearer;prosthetic socket;Quality of life;Questionnaires;Reaction;Refit;rehabilitation research;Rehabilitation therapy;Research;residual limb;Rest;Risk;Risk Reduction;Running;satisfaction;Scanning;Services;Skin;skin irritation;socket design;Suspensions;Technology;Tendon structure;Thick;Time;treadmill;United States Department of Veterans Affairs;Veterans;Walking;women versus men

PROJECT_TITLE: Improving Socket Fit in Female and Male Veterans with Transtibial and TransfemoralAmputation


ADMINISTERING_IC: HG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Two fundamental goals of genetic epidemiology, the estimation of individual-level disease risk and the identification of mutations that cause disease, promise to help inform personalized medical interventions, identify drug targets, and elucidate disease biology. However, existing genetic datasets overrepresent European ancestry individuals, limiting the identification of causal mutations and accuracy of disease risk prediction in non-Europeans populations, exacerbating ancestry-based health disparities. Most methods in genetic epidemiology consider data for one ancestry and disease at a time, whereas we will develop methods that share information across ancestries and diseases to further these fundamental goals in an equitable and powerful way.

PI_NAMEs: ROSSEN, JORDAN  (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: Acceleration;base;biobank;Biology;causal variant;Clinic;Collection;Data;Data Collection;data privacy;Data Set;Development;Disease;disorder risk;Drug Targeting;electronic health information;Electronic Health Record;Equity;Etiology;European;European ancestry;Genetic;genetic architecture;genetic epidemiology;genetic information;Genetic Risk;genetic variant;Goals;health disparity;health inequalities;health outcome disparity;high standard;improved;Individual;innovation;insight;interest;Intervention;Laplacian;Linkage Disequilibrium;Maps;Medical;Methodology;Methods;Modeling;Mutation;Pattern;Performance;Phenotype;polygenic risk score;Population;Population Heterogeneity;precision medicine;Publishing;Research;Research Personnel;Risk;risk prediction;Scoring Method;screening;Speed;Statistical Models;statistics;Sum;Time;trait;trend;Variant

PROJECT_TITLE: Methods for multi-ancestry and multi-trait fine-mapping and genetic risk prediction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Visual injury and disease affect millions of patients annually, but there is still much to learn about the mechanisms that impair visual processing in these conditions. Here, I will determine the chronic effects of an acute injury on distinct subpopulations of retinal ganglion cells, the retina’s output neurons that signal the brain. The results of the proposed experiments could contribute to understanding human diseases that affect the optic nerve, including glaucoma.

PI_NAMEs: ZAPADKA, THOMAS EUGENE (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Action Potentials;Acute;Address;Affect;Amacrine Cells;Anatomy;Area;Automobile Driving;Axon;axon growth;axon injury;axon regeneration;Brain;Brain region;Categories;Cell Death;cell injury;cell regeneration;Cell Survival;cell type;Cells;Cessation of life;Chronic;Closure by clamp;Cone;Confocal Microscopy;Data;Detection;Disease;Electrophysiology (science);experimental study;extracellular;Frequencies;Functional disorder;functional restoration;Future;ganglion cell;Glaucoma;Goals;Heterogeneity;human disease;improved;In Vitro;in vivo;injured;Injury;insight;Interneurons;Intervention;Ions;Kinetics;Learning;Light;lucifer yellow;Measures;Modeling;Morphology;Mus;Nerve Crush;nerve injury;Neural Retina;neurotransmission;novel;Operative Surgical Procedures;Optic Nerve;Optic Nerve Injuries;Outcome;Output;patch clamp;Pathway interactions;Patients;Pharmacology;Photoreceptors;Physiologic pulse;Physiological;Physiology;postsynaptic;Potassium;Predisposition;Process;Property;prophylactic;Publishing;Ramp;rational design;resilience;response;Retina;retinal axon;Retinal Diseases;Retinal Ganglion Cells;Rod;Role;Signal Transduction;Sodium;Stimulus;Surgical Models;Synapses;Techniques;Testing;Therapeutic;Time;Tissues;transcriptomics;Treatment Efficacy;Vision;Visual;Visual impairment;visual processing;voltage;Work

PROJECT_TITLE: Retinal Circuitry Response to Nerve Injury


NIH_SPENDING_CATS: Genetics;Kidney Disease

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative: Pathophysiologic disturbances in phosphate homeostasis involving the hormone FGF23, such as those in rare Mendelian disorders or common disorders such as chronic kidney disease (CKD), lead to severe endocrine and skeletal disease. These disorders involve a critical renal-bone regulatory axis and currently have inadequate treatments. We expect that our proposed studies will allow high-level training of a predoctoral fellow and reveal new mechanisms involved in crossover phosphate and localized inflammation providing novel therapeutic targets.

PI_NAMEs: SOLIS, EMMANUEL  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Ablation;absorption;Adenine;Affect;ATAC-seq;Automobile Driving;Binding;Biochemistry;bone;Bone Diseases;career development;Cells;Chronic;Chronic Kidney Failure;Clinical;Collaborations;Complex;cytokine;Cytokine Signaling;Disease;Disease Progression;Educational Status;Endocrine;Endocrine System Diseases;Environment;Ethics;Family member;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;Functional disorder;Future;Future Teacher;gain of function;Gene Expression;Gene Family;Gene Targeting;Genes;Genetic Transcription;Genomics;Goals;Grant;Health;Homeostasis;Hormones;I-kappa B Proteins;Immunoblot Analysis;improved;improved outcome;In Vitro;in vitro testing;in vivo;Indiana;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;inorganic phosphate;Journals;Kidney;Lead;Lipopolysaccharides;loss of function;loss of function mutation;LoxP-flanked allele;Manuscripts;MAP Kinase Gene;Mediating;meetings;Mentors;Messenger RNA;Metabolic Bone Diseases;Metabolism;Minerals;Modeling;Molecular;mortality;mouse model;multiple omics;Mus;Musculoskeletal;National Research Service Awards;new therapeutic target;NF-kappa B;novel;Oral;Organ;Osteocytes;Outcome;overexpression;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphorylation;Plasma;pre-doctoral;Preparation;Production;programs;Progressive Disease;Protein Isoforms;Proximal Kidney Tubules;rare mendelian disorder;receptor;Recombinants;Regulation;Regulatory Pathway;Renal function;Repression;Research;Research Personnel;Research Training;Resistance;response;Secondary Hyperparathyroidism;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal disorder;skills;Stimulus;System;targeted treatment;Testing;Therapeutic Intervention;Tissues;TLR4 gene;TNF gene;Training;transcriptome sequencing;Transfection;Transgenic Mice;Vitamin D;Western Blotting;Writing

PROJECT_TITLE: Targeting Inflammation to Improve FGF23-mediated Mineral Metabolism in CKD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE: Psychopathology places a substantial cost on individuals and society, yet there has been limited success in deriving neuroimaging-based models with enough accuracy to be clinically useful in predicting symptoms. This proposal seeks to integrate two distinct frameworks using a novel multi-task neural network approach that may better capture the neurodevelopmental origins of psychopathology. The overarching goal of this work is to derive accurate neuroimaging-based predictions of psychopathology that can better differentiate individuals and map onto within-subject changes across time, which may prove useful in uncovering novel neurodevelopmental biomarkers of psychopathology.

PI_NAMEs: JIRSARAIE, ROBERT J (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Adolescence;Adolescent;Age;age difference;age related decline;aging brain;Aptitude;Area;Biological Markers;Brain;Brain Diseases;Brain Pathology;career;catalyst;Childhood;Clinical;Cognitive;connectome;cost;course development;Data;Data Set;deep learning;deep learning model;Development;Dimensions;Early Diagnosis;Ensure;Exhibits;experience;Fostering;functional outcomes;Funding;Genetic Predisposition to Disease;Goals;Human;Impairment;improved;Individual;Individual Differences;innovation;insight;Knowledge;life span;longitudinal analysis;machine learning method;Maps;Mental disorders;Methods;Modality;Modeling;multi-task learning;multimodal neuroimaging;multimodality;multitask;neural;neural network;neurodevelopment;neuroimaging;novel;novel marker;novel strategies;Performance;personalized intervention;Practice Guidelines;prediction algorithm;Principal Investigator;Property;Psychopathology;Psychoses;Psychosocial Factor;Quality of life;Reproducibility;Research;Research Personnel;Risk;Risk Factors;risk prediction;Sampling;Severities;skills;Societies;specific biomarkers;Stress;Substance abuse problem;success;Symptoms;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Predicting trajectories of psychopathology using multimodal neuroimaging and multi-task learning


FUNDING_MECHANISM: OTHERS

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Transfers into and out of bed for wheelchair users can be dangerous and stressful to both the wheelchair user and caregivers who are assisting them with the transfer. Several mechanical transfer devices are commercially available, but they can be very large, expensive, and difficult to use. The AgileLife Patient Transfer System is a robotic bed and custom manual wheelchair that work together to automatically transfer a person to and from a bed. The goal of this proposal is to adapt the patient transfer system and a standard power wheelchair (Group 3) with seating functions so that the patient transfer system will be able to be used by wheelchair users with more complex and severe impairments.

PI_NAMEs: DUVALL, JONATHAN  (contact)

PROJECT_TERMS: assistive robot;Back;Back Injuries;Back Pain;Beds;career;Caregivers;Community Participation;Complex;Computer software;Custom;Dangerousness;design;Devices;disability;Disabled Persons;Docking;Elevator;Engineering;Epidemic;Equipment;experience;Floor;Focus Groups;Goals;Head;Health;high risk;Home;hospital bed;Hospitals;Immobilization;Impairment;improved;indexing;Individual;Individuals with physical disabilities;Injury;iterative design;Leg;Lifting;Long-Term Care;Manual wheelchair;Manuals;manufacture;Mechanics;Medical center;member;Mentors;Mobility decline;Modification;Monitor;Movement;Musculoskeletal Diseases;Neurologic;Participant;patient responsibilities;Patient Transfer;Patients;Persons;physical therapist;Policies;Positioning Attribute;Powered wheelchair;prototype;Quadriplegia;Quality of life;quantum;Questionnaires;Research;Rest;Risk;Risk Reduction;Robotics;Safety;Scientist;Self-Help Devices;skills;Specific qualifier value;State Government;Surveys;System;Techniques;Technology;Technology Transfer;Testing;tool;Training;United States;United States National Aeronautics and Space Administration;usability;Veterans;Wheelchair user;Wheelchairs;Work

PROJECT_TITLE: Modification of Group 3 Power Wheelchair and Automated Patient Transfer Bed for Compatibility

STUDY_SECTION_NAME: Career Development Program - Panel I[RRD8]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Ovarian Cancer;Patient Safety;Rare Diseases;Women's Health Research

ORG_CITY: TEL AVIV

ORG_COUNTRY: ISRAEL

ORG_FIPS: IS

ORG_NAME: TEL AVIV UNIVERSITY

PHR: Inhibiting beta-adrenergic and COX-2 signaling during the perioperative period to reduce  ovarian cancer progression Project Narrative: In women undergoing ovarian cancer surgery, most deaths are related to cancer progression and cancer metastases. Stress and inflammatory responses to having cancer and undergoing surgery have been shown to contribute to cancer progression and metastatic outbreak, and thus we herein propose to treat ovarian cancer patients with repurposed non-patented medications to reduce these deleterious responses around the time of surgery. If this exploratory study will yield promising outcomes on ovarian cancer progression-related indices, including reduced metastatic progression, larger studies will be justified to test long-term survival advantages of this novel approach in ovarian cancer patients.

PI_NAMEs: BEN-ELIYAHU, SHAMGAR  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acceleration;Address;Adherence;Adrenergic Agents;Adrenergic Antagonists;Adrenergic beta-Antagonists;adrenergic stress;Adverse event;Agreement;Anesthesia procedures;Animal Model;Anti-Anxiety Agents;Anxiety;arm;Attenuated;B-Lymphocytes;Back;beta-adrenergic receptor;Bioinformatics;Biological;biological adaptation to stress;Biological Assay;Biological Markers;Blood specimen;Breast;Breast Cancer Patient;Cancer Patient;Cancer Prognosis;cancer surgery;cancer therapy;Cardiovascular system;CD8-Positive T-Lymphocytes;cell growth;cerebrovascular;Cessation of life;Characteristics;Clinical;Clinical Trials;cohort;colon cancer patients;Colorectal;cost;Coxibs;CREB1 gene;critical period;Day Surgery;Death Rate;Dendritic Cells;Disease Outbreaks;Disease-Free Survival;Distress;Dose;Enzyme-Linked Immunosorbent Assay;Enzymes;epidemiology study;Ethnic Origin;Exhibits;Family;follow-up;Funding;Funding Opportunities;Genetic Transcription;Goals;Growth;Hemorrhage;hospital readmission;Hospitals;Immune;Immune response;improved;In Vitro;in vivo;indexing;infection rate;Inflammatory;Inflammatory Response;inhibitor;Institutional Review Boards;Intervention;Israel;Laboratories;Leucocytic infiltrate;Lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Medical;Medical center;medication administration;medication safety;Melanoma;metastatic process;Metastatic/Recurrent;Molecular;molecular marker;monocyte;Morbidity - disease rate;Neoplasm Metastasis;novel;novel marker;novel strategies;off-patent;Operative Surgical Procedures;Opioid;Outcome;Outcome Assessment;Outcome Study;ovarian neoplasm;Pain;Pancreas;Patients;payment;Perioperative;Perioperative complication;perioperative mortality;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Pilot Projects;Placebo Control;Placebos;Population Heterogeneity;primary outcome;Process;Propranolol;Prostaglandins;PTGS2 gene;randomized placebo-controlled clinical trial;randomized, clinical trials;recruit;Recurrence;Research;response;Safety;Sampling;secondary outcome;Signal Pathway;Signal Transduction;Solid;Solid Neoplasm;Stress;Supervision;Surgical complication;Surgical Wound Infection;survival outcome;Survival Rate;Testing;Time;Transcription Factor AP-1;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Debulking;tumor progression;Tumor Tissue;Universities;whole genome;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-5 (M1)]