NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This collaborative, innovative and high impact interdisciplinary project (continuing renewal of our ongoing caries risk study U01-DE021412-11) provides a unique opportunity to assess U.S. children over time culminating with much needed access and focus on adolescence- a life stage in which people have persistent caries problems over the last few decades, is challenging to recruit, and has been largely neglected in oral health research, practice, and policy. The relevance, impact, and significance of the project is that it will result in the creation of critically important and novel prediction models, and understanding of relationships among oral and systemic health risk factors and comorbidities into early adolescence, which is essential to designing future implementation efforts to target efficient, cost-effective, preventive, person-centered care for dental caries, as well as collaborative interprofessional care to reduce disparities and improve adolescents' health. This proposal is responsive to NIDCR’s 2021-2026 Strategic Plan Goals 2 [Develop more precise and individualized ways of managing and preventing oral and craniofacial diseases ] and 3 [Accelerate the translation of research and the uptake of new discoveries into oral and general healthcare practices that reduce health inequities and disparities and improve oral health outcomes for individuals and communities worldwide].

PI_NAMEs: FONTANA, MARGHERITA R (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: 15 year old;19 year old;Acceleration;access disparities;Address;Adolescence;Adolescent;adolescent health;Adopted;Adult;Affect;Age;Alcohol consumption;Anterior;anxiety symptoms;Behavior;behavioral health;Beverages;Biological;Caring;Child;Childhood;Chronic;clinical decision-making;cohort;Communities;comorbidity;cost;cost effective;cost effectiveness;craniofacial;Data;deciduous tooth;Dental Care;Dental caries;Dental Research;depressive symptoms;design;Development;Disease;Disparity;disparity reduction;early adolescence;Enrollment;Ensure;experience;Family Demographies;follow-up;Food Preferences;Future;future implementation;Goals;Health;Health behavior;health care delivery;health care model;health care settings;health disparity;health inequalities;Health Planning;Health Services Accessibility;Healthcare;Historical Demography;implementation efforts;improved;Incidence;Individual;infancy;innovation;Intervention;Lesion;Life;Life Cycle Stages;Longitudinal Studies;longitudinal, prospective study;Medical;Medical History;Medical Research;Methods;National Institute of Dental and Craniofacial Research;neglect;novel;Nursing Research;Obesity;Oral;Oral health;Outcome;Pattern;permanent tooth;person centered;Personal Satisfaction;personalized care;Persons;Pharmaceutical Preparations;Phase;Policies;Policy Developments;predictive modeling;Prevalence;prevent;Preventive;primary caregiver;Primary Dentition;Primary Health Care;Public Health;Publishing;Questionnaires;Recommendation;recruit;Reporting;Research;Research Design;Risk;Risk Behaviors;Risk Factors;risk stratification;School-Age Population;Screening procedure;sex;Smoking;sociodemographics;soft drink;Sports;Strategic Planning;success;Surface;Therapeutic;Time;Tooth structure;Translational Research;uptake;vaping;Work

PROJECT_TITLE: Predicting Caries Lesion Patterns and Trajectories in Underserved Children, from Infancy to Early Adolescence, in Primary Healthcare Settings


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cannabinoid Research;Dementia;Endocannabinoid System Research;Neurodegenerative;Neurosciences;Prevention;Therapeutic Cannabinoid Research

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Alzheimer’s disease (AD) effects an estimated 5.8 million Americans with the number of patients expected to triple over the next 30 years, yet there are currently no medications that stop or prevent the disease. Critically, the identification of the mechanisms that precede the pathogenesis of AD and are distinct from normal healthy aging, which will be investigated in this application, will likely inform novel therapeutic strategies, including ones that may be used before the onset of disease symptoms which makes this project highly relevant to public health.

PI_NAMEs: RIZZO, STACEY J (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: 2-arachidonylglycerol;5'-AMP-activated protein kinase;Acceleration;Age;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;Anti-Inflammatory Agents;apolipoprotein E-4;Arachidonic Acids;Astrocytes;attenuation;Autophagocytosis;Biochemical;Biological Markers;Biological Models;Biology of Aging;Brain;Cardiovascular Diseases;cell type;Cells;Clinical Trials;comorbidity;Data;Diabetes Mellitus;Disease;Disease Progression;Disease susceptibility;disorder prevention;early onset;Endocannabinoids;Enzymes;Evaluation;experimental study;FRAP1 gene;Genetic;genetic approach;Genetic Models;Genetic Risk;genetic risk factor;Goals;healthspan;healthy aging;high risk;Immune;immunoregulation;improved;Individual;Inflammation;Inflammatory;inhibitor;innovation;insight;Intervention;Late Onset Alzheimer Disease;life span;Lipase;Longevity;Malignant Neoplasms;Modeling;Molecular;Monoacylglycerol Lipases;mouse model;mTOR inhibition;mTOR Inhibitor;Mutation;Neurodegenerative Disorders;neuroinflammation;Neurons;neuroprotection;normal aging;novel;novel therapeutic intervention;novel therapeutics;Onset of illness;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Population;Pre-Clinical Model;Prevalence;prevent;Prevention;Process;prophylactic;Prophylactic treatment;Public Health;Regulation;Reproducibility;Research;risk variant;Role;Signal Transduction;Sirolimus;Symptoms;systemic inflammatory response;Testing;Therapeutic;Therapeutic Agents;tool;TREM2 gene

PROJECT_TITLE: Role of Lifespan Intervention on the Regulation and Progression of Alzheimer's Disease


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Data Science

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PI_NAMEs: REEDS, DOMINIC N (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Address;career development;Clinical;Clinical Sciences;Collaborations;Communities;community engaged research;Competence;course development;Data;Data Science;Development;Discipline;education resources;Educational Curriculum;Educational workshop;efficacy evaluation;Equity;Faculty;flexibility;Fostering;Goals;health equity;Hybrids;implementation science;Improve Access;improved;Individual;Informatics;informatics training;Infrastructure;innovation;Institution;Leadership;leadership development;life span;Medicine;Mentors;Methods;multidisciplinary;online course;Outcome;patient engagement;Performance;Population;Process;Program Development;programs;recruit;Research;Research Personnel;Research Training;Resources;satisfaction;Science;skills;Special Population;tool;Training;Training Programs;translational goal;Translational Research;Universities;Washington;Workforce Development

PROJECT_TITLE: Washington University Institute of Clinical and Translational Sciences (KL2)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Sexually Transmitted Infections;Substance Misuse;Women's Health Research

ORG_CITY: VANCOUVER

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF BRITISH COLUMBIA

ORG_STATE: BC

ORG_ZIPCODE: V6T 1Z3

PHR: PROJECT NARRATIVE Currently, there remains a lack of research on integrated interventions to address co-occurring harms related to HIV/STI and overdose epidemics, particularly among sex workers, who face disproportionate HIV and STI burdens and severe gaps in access to evidence-based addiction services. While structural and system-level interventions such as community empowerment and changes in policing practices have strong potential to mitigate harms associated with overlapping HIV/STI and overdose epidemics, there remains a scarcity of data on how the implementation of such interventions impacts HIV/STI and overdose incidence and engagement with addiction services among sex workers. As such, the goal of this competing renewal is to evaluate the impacts of `naturally occurring' interventions of community empowerment (CE) and changes in policing practices on incidence of HIV/STIs and overdose (OD), and engagement with addiction services among street and indoor sex workers in an urban Canadian setting. !

PI_NAMEs: GOLDENBERG, SHIRA MIRIAM;KRUSI, ANDREA  (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: addiction;Address;administrative database;Advocacy;Area;behavioral and social science;British Columbia;cohort;Communities;community empowerment;community intervention;community organizations;comorbidity;comparison intervention;Data;Data Collection;Databases;Drug usage;Drug user;Epidemic;evidence base;Exposure to;female sex worker;gaps in access;Goals;Government;Guidelines;Health;Health Insurance;Health Personnel;Healthcare;Helping to End Addiction Long-term;HIV;HIV/HCV;HIV/STD;improved;Incidence;Individual;Intervention;marginalized population;Measures;mortality;Naloxone;North America;novel;Opiate Addiction;opioid epidemic;opioid misuse;opioid use;Outcome;Overdose;overdose prevention;peer;Pharmaceutical Preparations;point of care;point of care testing;Police;Policies;Population;Prevention;programs;prospective;Questionnaires;recruit;Reporting;Research;response;Risk;Role;Scientific Advances and Accomplishments;screening;sensitivity training;Serology;service utilization;Services;sex;Site;Social Work;syndemic;System;Testing;Time;transmission process;United States National Institutes of Health;Violence;Woman;Women's prevalence;Work

PROJECT_TITLE: Impacts of structural and system-level interventions on HIV/STI and overdose epidemics among SWs

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: We have found that as mice age or suffer from disease, they activate more and more of their white blood cells to release highly toxic material from their nuclei, called NETs, which induces both inflammation and thrombosis. Thrombotic events are now the biggest killer in United States and heart failure, caused by chronic inflammation, is on the rise. The goal of this application is to figure out how the release of NETs and its consequences could be inhibited to prevent thrombosis and improve the health of our aging population.

PI_NAMEs: WAGNER, DENISA D (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TITLE: Inflammation and thrombosis fuel cardiovascular and pulmonary disease: Focus on the interplay of neutrophil inflammasomes with NETs


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Multiple myeloma, a bone marrow cancer characterized by the secretion of substantial quantities of abnormal antibodies (monoclonal protein), is currently considered to be incurable, and despite improvements in survival over the past decade, nearly all patients will die of their disease. We have developed a novel strategy to kill myeloma cells by disrupting monoclonal protein secretion via inhibition of Rab protein-mediated intracellular trafficking processes. The ultimate goal of the studies described herein is the development of novel therapeutic agents which can be used to safely and effectively treat multiple myeloma so that these patients may live longer and develop fewer complications from their disease.

PI_NAMEs: HOLSTEIN, SARAH A (contact);MOHS, AARON M.;WIEMER, DAVID F

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Abbreviations;AGFG1 gene;analog;Antibodies;Apoptosis;arm;Azoles;Binding;Biodistribution;bisphosphonate;Bone Marrow;Cell Death;Cell membrane;Cells;Clinic;Clinical;clinically relevant;Crystallography;design;Development;Disease;Dose;Dose Limiting;Drug Combinations;Drug Delivery Systems;Drug Kinetics;drug resistance development;efficacy evaluation;efficacy testing;endoplasmic reticulum stress;Enzyme Inhibition;Enzymes;Event;Extramedullary;farnesyltranstransferase;Formulation;Future Generations;geranylgeranylation;Goals;Half-Life;heart function;Hematology;Hepatic;Hepatotoxicity;Hyaluronic Acid;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;inhibitor therapy;isoprenoid;Lead;Length;Link;Malignant - descriptor;Malignant Bone Marrow Neoplasm;Malignant Neoplasms;Mediating;Metabolic;Modeling;Molecular Weight;Morbidity - disease rate;Multiple Myeloma;Mus;Myeloma Proteins;Nervous System Physiology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;phosphonate;Plasma;Plasma Cells;Polymers;Positioning Attribute;preclinical study;Process;Prodrugs;Production;Proliferating;Property;Protein Geranylgeranylation;Protein Secretion;protein transport;Proteins;Renal function;response;stereochemistry;Structure;System;Tail;Therapeutic;Therapeutic Agents;Toxic effect;Toxicology;trafficking;Translating;tumor;uptake;Veins;Vesicle;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Geranylgeranyl diphosphate synthase inhibitor therapy for multiple myeloma

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: WORCESTER

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Skeletal muscle is formed by protein filaments that slide past each other, pulled by miniature molecular motors that produce force and cause shortening. In healthy relaxed muscle, the motors are switched off in an energy-saving mode, while genetic mutations can damage the motors, causing increased energy usage and muscle diseases. We will use powerful microscopes to observe the atomic structure of these motors, illuminating how they work normally, malfunction in disease, and are repaired by drugs that restore or enhance their function.

PI_NAMEs: PADRON, RAUL  (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Actins;Animals;antagonist;Area;ATP phosphohydrolase;Binding;Biochemical;Bone structure;Cardiac;Collaborations;connectin;Consumption;Contracts;Cryoelectron Microscopy;Disease;DNA Sequence Alteration;Drug Targeting;Energy consumption;Equilibrium;Exhibits;Fiber;Filament;H-Meromyosin;Head;Human;Impairment;insight;Laboratories;Life;Measures;Microscope;MLL gene;Modeling;Molecular;Molecular Conformation;Molecular Motors;Motor;Movement;Mus;Muscle;Muscle Contraction;Muscle function;Muscle relaxation phase;Myopathy;Myosin ATPase;Oryctolagus cuniculus;particle;Pharmaceutical Preparations;Pharmacotherapy;Proteins;Relaxation;repaired;Resolution;Role;Side;skeletal;Skeletal Muscle;Slide;Structure;Tail;Testing;Therapeutic;Thick;Thick Filament;Thin Filament;Work;X ray diffraction analysis

PROJECT_TITLE: Dissecting the structural origin of relaxation in skeletal muscle

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In this proposal we will seek to develop, via novel experimental and computational technology development, a next-generation massively multiplexed combinatorial genetic screening platform for dissecting mechanisms of cell fate specification. As genes and mutations typically act in combination through physical and pathway level interactions to drive cellular and organismal phenotypes, this approach will have broad applicability for advancing our fundamental understanding of biological systems and therapeutics development.

PI_NAMEs: IDEKER, TREY ;MALI, PRASHANT  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Address;Bar Codes;Basic Science;Bioinformatics;Biological Assay;biological systems;Buffers;Cell Culture Techniques;cell fate specification;cell killing;Cell model;Cell Reprogramming;cell type;Cells;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;computational platform;computerized tools;Computing Methodologies;CRISPR screen;Data;Data Set;Dimensions;directed differentiation;DNA;Elements;Enabling Factors;engineered stem cells;Engineering;epigenome;flexibility;Gene Expression;gene interaction;Generations;Genes;Genetic;genetic analysis;Genetic Screening;Genetic Transcription;Genome;Genome engineering;Genomics;Genotype;human disease;Human Genome;Individual;insight;Joints;Learning;Libraries;Link;Machine Learning;machine learning model;Maintenance;Mali;Malignant Neoplasms;Maps;Measures;Methods;MicroRNAs;Modality;Mutation;neoplastic cell;neural;neurodevelopment;Neurons;next generation;novel;Open Reading Frames;overexpression;Pathway interactions;PF4 Gene;Phenotype;pluripotency;pluripotent stem cell differentiation;prevent;Principal Investigator;Reagent;Recipe;Regenerative Medicine;Repression;Research;Research Personnel;RNA;screening;Screening Result;synthetic lethal interaction;System;Systems Biology;Systems Development;technology development;Therapeutic;therapeutic development;tool;transcription factor;transcriptome;Translating;Undifferentiated;Variant;vector

PROJECT_TITLE: Next generation massively multiplexed combinatorial genetic screens

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Amyloids are typically associated with neurological disorders. Our group has found that cells can assemble physiological amyloids to store proteins and active different pathways. Cells initiate physiological amyloidogenesis programs to sustain viability when confronted to severe environmental insults encountered in normal and disease conditions.

PI_NAMEs: LEE, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Amyloid;amyloidogenesis;Biochemical;Biological;Biological Assay;Biology;Cells;Characteristics;Color;Cytoplasmic Structures;detention center;Development;Dinucleoside Phosphates;Dinucleotide Repeats;Disease;DNA;Funding;Genome;Germ Cells;Grant;granule cell;Human;Human Genome;Immobilization;Imprisonment;In Vitro;insight;interest;Junk DNA;Laboratories;Liquid substance;Malignant Neoplasms;Mammalian Cell;Membrane;Metabolism;molecular imaging;National Institute of General Medical Sciences;Nervous System Disorder;Nuclear;Organelles;Pathologic;Pathway interactions;Phase Transition;Physical condensation;Physiological;Play;Process;programs;Property;Protein Dynamics;Proteins;Regulatory Pathway;Reporting;Research;response;Ribosomal RNA;Ribosomes;RNA;RNA Sequences;Role;Scientist;single molecule;Site;Solid;Stimulus;Stress;stress granule;stressor;Translations;Untranslated RNA;Work

PROJECT_TITLE: The Nucleolar Detention Center: A Hub of Long Noncoding RNA that Imprison Proteins during Stress

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: Knowledge of the etiology of type 2 diabetes (T2D), a pandemic that affects >400 million worldwide, is incomplete. Elevations in certain lipid moieties precede glucose abnormalities in animal models of type 2 diabetes, however, the longitudinal relationship between lipids and T2D in humans is unclear. Using two well- characterized cohorts with >10-year follow-up data from participants prospectively monitored for incident prediabetes, T2D and complications, our planned lipidomics analysis will provide novel data on the role of specific lipid signatures (sphingolipids and ceramides) during the transition from normal glucose regulation through prediabetes to nascent diabetes and diabetes complications.

PI_NAMEs: DAGOGO-JACK, M.D., D.SC., SAMUEL  (contact);MANDAL, NAWAJES

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Affect;Age;Ancillary Study;Animal Model;Authorization documentation;Automobile Driving;base;Beta Cell;Biological Assay;biracial;blood glucose regulation;Blood Vessels;Body mass index;Cardiovascular Diseases;case control;Cell Physiology;Ceramides;Chronic;cohort;Cohort Studies;Complications of Diabetes Mellitus;Control Groups;coronary calcium scoring;Data;design;Development;Diabetes Mellitus;diabetes prevention program;Diabetic Retinopathy;Diagnosis;Dihydrosphingosine;dihydrosphingosine 1-phosphate;Enrollment;Ethnic Origin;Etiology;Family;Family history of;Fatty Acids;follow-up;Functional disorder;Funding;Galactosylceramides;Glucose;Human;Individual;insulin sensitivity;Intervention;Kidney Diseases;Knowledge;Lactosylceramides;Life Style;lifestyle intervention;Link;lipidomics;Lipids;longitudinal analysis;Longitudinal cohort;macrovascular disease;Measures;Mediating;Metabolic Diseases;Metabolism;Metformin;Minor;Monitor;Neuropathy;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Obesity;Outcome;Outcome Study;pandemic disease;Participant;Pathogenesis;Phenotype;placebo group;Plasma;Population;Prediabetes syndrome;predictive marker;prevent;Process;Prognostic Marker;prospective;Randomized;Recording of previous events;recruit;Regulation;Resources;response;Retinal Diseases;Risk Factors;Role;Sampling;Sampling Studies;Secure;sex;specific biomarkers;Specimen;sphinganine;Sphingolipids;Sphingomyelins;Sphingosine;sphingosine 1-phosphate;Subgroup;Testing;Time;Treatment Efficacy;United States National Institutes of Health;Variant

PROJECT_TITLE: Ceramides and Sphingolipids as Predictors of Incident Dysglycemia

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Current approaches for treatment of organ injury has focused on the delivery of growth factors or stem cells without any major benefit, in which fibrotic scarring interfere with functional integrity of the damaged organs. We have shown that specialized endothelial cells lining the blood vessels in each organ by production of unique growth factors could support organ repair without provoking fibrosis or tumorigenesis. To translate the potential of endothelial cells for regenerative medicine to clinic, we have proposed experiments to understand how endothelial cells acquire organ-specific functions to optimize their efficacy in regeneration, with the intention of transplantation these tissue-specified ECs to augment the repair of lung, blood and broken hearts without scarring.

PI_NAMEs: RAFII, SHAHIN  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Adult;Allogenic;Award;Blood;Blood Vessels;Cardiac;Cell Line;Cells;cellular transduction;Cicatrix;Clinic;Clinical Trials;Coculture Techniques;Code;efficacious treatment;Endothelial Cells;Engineering;experimental study;FDA approved;fetal;Fibrosis;follow-up;Functional disorder;Genetic Transcription;Goals;Growth Factor;healing;Heart;Hematopoietic;Hepatic;Heterogeneity;Homeostasis;Human;human induced pluripotent stem cells;In Vitro;in vivo;Infusion procedures;innovation;Intention;knock-down;Lung;lung repair;Macaca nemestrina;Mission;Molecular;Monkeys;Morphogenesis;Mus;National Heart, Lung, and Blood Institute;Natural regeneration;nonhuman primate;novel;Organ;organ injury;organ regeneration;organ repair;Organoids;Outcome;overexpression;Pathway interactions;Production;programs;reconstitution;Recovery;regenerative;Regenerative Medicine;repaired;replacement tissue;Research;RNA;Safety;Signal Transduction;Specific qualifier value;stem cells;Technology;Testing;Therapeutic;Tissue Engineering;tissue repair;Tissue Transplantation;Tissues;Translating;Translations;Transplantation;tumorigenesis;vascular contributions

PROJECT_TITLE: Adaptable tissue-specific endothelial cells for organ regeneration


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cocaine;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Methamphetamine;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  PUBLIC HEALTH RELAVENCE Synthetic drugs of abuse, including stimulants (e.g., cathinones, methamphetamine) and opioids (e.g., fentanyl) are associated with high rates of abuse and toxicity, and although these drugs are often used as mixtures (e.g., multiple stimulants, or stimulants and opioids), relatively little is known about how interactions among them drugs impact their abuse-related and toxic effects. This project combines well-established animal models of abuse (self-administration) and toxicity (cardiovascular recordings) with quantitative analysis to determine the nature of the interactions between the abuse-related and toxic effects of stimulant-opioid drug mixtures that are at the center of the current polysubstance abuse epidemic. Together, results of the proposed studies will provide essential information about the complexities associated with the co-use of multiple substances from different pharmacological classes that will ultimately advance efforts to develop novel and effective treatments for abuse-related and toxic effects of polysubstance abuse.

PI_NAMEs: COLLINS, GREGORY THOMAS (contact)

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Adverse reactions;Affect;Aggressive behavior;analog;Animal Model;bath salts;Blood Pressure;Caffeine;Canis familiaris;Cardiopulmonary;Cardiovascular system;cathinone;Cessation of life;Cocaine;cocaine self-administration;Complex;Designer Drugs;Development;Diarrhea;Dose;Drug Interactions;drug market;drug of abuse;Drug usage;effective therapy;Effectiveness;Emergency department visit;Epidemic;epidemiologic data;Female;Female Adolescents;Fentanyl;fentanyl self-administration;fentanyl use;Future;Heart Rate;Heroin;High School Student;Hypertension;improved;Incidence;Individual;innovation;Knowledge;Laboratories;Learning;Life;Life Experience;Link;Literature;male;Male Adolescents;Marketing;mephedrone;Methamphetamine;Modeling;Monitor;Naloxone;Nature;novel;Opiate Addiction;Opioid;opioid abuse;opioid mortality;opioid overdose;opioid user;opioid withdrawal;Overdose;overdose death;Patient Self-Report;Pattern;Pharmaceutical Preparations;pharmacologic;Pharmacology;polysubstance abuse;polysubstance use;prescription opioid;Procedures;Public Health;Rattus;Recording of previous events;recreational drug use;Recreational Drugs;reinforcer;Reporting;Research Project Grants;Respiration;Self Administration;Stimulant;stimulant use;stimulant user;Students;Surveys;synthetic drug;synthetic opioid;Tachycardia;Testing;Time;Toxic effect;trend;United States;Violence;vocalization;Vulnerable Populations;Withdrawal;women subjects;Work

PROJECT_TITLE: Bath Salts: abuse-related and toxic effects


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE Compared to men, late-life women are at greater risk of cerebral small vessel disease, bear a greater burden of Alzheimer’s disease, and may develop Alzheimer’s disease via different pathways. NIH has recently prioritized understanding sex differences in Alzheimer’s disease and related dementias, specifically highlighting sex in its high priority research area in epidemiology of Alzheimer’s disease and related dementias. The proposed research is relevant to public health because understanding whether cerebral small vessel disease can explain sex differences in the Alzheimer’s disease pathophysiological cascade in the population at large can provide insight into markers of target engagement and sex-specific intervention targets which could be used to reduce Alzheimer’s disease dementia.

PI_NAMEs: SHAABAN, C. ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;apolipoprotein E-4;Area;Award;Biological Markers;Blood Vessels;Brain;career;career development;cerebral microbleeds;Cerebral small vessel disease;cerebrovascular;Cerebrum;Clinical;cohort;comorbidity;Data;data harmonization;Dementia;Deposition;Development;Disease Marker;Disproportionately impacts women;Early Intervention;Education;Epidemiologic Methods;Epidemiology;Event;Evolution;experience;Female;Functional disorder;Future;Gender;Goals;human old age (65+);Image;Impairment;improved;Incidence;innovation;insight;Intervention;Knowledge;late life;leadership development;Life Expectancy;Magnetic Resonance Imaging;Measures;men;Mentored Research Scientist Development Award;Mentors;Methods;mild cognitive impairment;Modeling;neuroimaging;neuroimaging marker;Neurosciences;older adult;older men;older women;Pathologic;Pathway interactions;personalized intervention;Persons;Population;population based;Positron-Emission Tomography;programs;Public Health;Reporting;Research;Research Personnel;Research Priority;Risk;Role;Sampling;Sampling Studies;Scientist;Selection Bias;sex;Sex Differences;Target Populations;tau aggregation;tau Proteins;Testing;Time;Tissues;Training;United States National Institutes of Health;vascular contributions;Venous;Visualization;White Matter Hyperintensity;Woman;Work

PROJECT_TITLE: Population neuroscience of sex differences in the Alzheimer's disease biomarker cascade: The role of cerebral small vessel disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE As the organism ages, adult regenerative neural stem cell niches no longer produce new neurons. Adult neurogenic niches have been found to be important for aspects of learning and memory, raising the intriguing possibility that boosting the production of neurons by these niches may help preserve or enhance cognitive function with advancing age. Uncovering the immune-based mechanisms underlying the decline and rejuvenation of adult neurogenic niches during aging should give important insights into the factors that control regeneration in the normal aging nervous system as well as in age-related neurodegenerative diseases such as Alzheimer’s disease.

PI_NAMEs: BRUNET, ANNE  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;Adult;Affect;Age;age related changes;age related neurodegeneration;age-related disease;Aging;aging brain;aging related;Alzheimer's Disease;animal old age;Antigens;Biological Assay;Blood;Brain;Brain region;cell type;Cells;Clonal Expansion;Clone Cells;Coculture Techniques;cognitive enhancement;cognitive function;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Deterioration;Elderly;Endothelial Cells;Environmental Risk Factor;Evaluation;Exercise;exhaustion;Exhibits;experimental study;functional decline;functional restoration;Goals;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunofluorescence Immunologic;immunoregulation;Immunotherapy;Impairment;improved;In Vitro;in vivo;Individual;Infiltration;insight;Interferons;Knowledge;Learning;Libraries;Location;machine learning model;Memory;Microglia;middle age;Mus;Natural regeneration;nerve stem cell;Nervous System;neuroblast;Neurodegenerative Disorders;neurogenesis;Neurons;Neurophysiology - biologic function;normal aging;Older Population;Organ;Organism;Play;preservation;Prevalence;prevent;Production;Proliferating;regenerative;Rejuvenation;response;restoration;Role;Signal Transduction;single-cell RNA sequencing;stem cell niche;stem cell proliferation;subventricular zone;T cell infiltration;T cell receptor repertoire sequencing;T cell regulation;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;Testing;Tissues;transcriptome;Work

PROJECT_TITLE: T cells in the aging brain

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Lung Cancer;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE The proposed project will answer key questions to inform the HIV, oncology, and geriatric clinical management of older people living with HIV (PLWH) diagnosed with a non-AIDS defining cancer (NADC). In order to disentangle the influence of HIV from the socio-behavioral factors associated HIV acquisition, we will leverage claims data from more than 5 million Medicaid beneficiaries across 14 states between 2001-2017 which provides an appropriate comparison population for older (i.e., >50 years of age), low income PLWH. Findings from this study will inform how aging in the presence of HIV affects the risk and consequences of non-AIDS defining cancers, and impacts HIV care and age-related outcomes among older adults.

PI_NAMEs: JOSHU, CORINNE E. (contact);LAU, BRYAN

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Admission activity;Affect;Age;age related;Age Years;Aging;aging population;antiretroviral therapy;beneficiary;Cancer Control;cancer diagnosis;cancer prevention;cancer therapy;cancer type;Caring;Cessation of life;Chemotherapy and/or radiation;Chronic;Clinical Management;cohort;Cohort Studies;Colorectal Cancer;comorbidity;comparison group;Complement;Continuity of Patient Care;Data;Dementia;demographics;Development;Diagnosis;Elderly;Enrollment;Ethnic Origin;Event;experience;Female;Fracture;General Population;Health Services Accessibility;healthy aging;High Prevalence;high risk;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;Incidence;Infection;Knowledge;Length of Stay;Low income;Low Income Population;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medicaid;Medicare;men;Modernization;mortality;multidisciplinary;older adult;Older Population;Oncology;Operative Surgical Procedures;Outcome;Persons;Polypharmacy;Population;Population Heterogeneity;Poverty;Prevention strategy;Prognosis;Race;racial difference;Radiation therapy;Reporting;Resources;Risk;Risk Factors;Sample Size;sex;Sex Differences;Smoking;Social Behavior;Socioeconomic Status;Subgroup;therapy adherence;Time;treatment strategy;Treatment-Related Cancer;Woman

PROJECT_TITLE: Medicaid data as a complement to cohort studies for investigating cancers among older people with HIV


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE The rapid adoption of mobile and interactive technologies by American families has outpaced research on their potential effects on child development and health. This project proposes to examine how the mobile media use of parents and young children predict changes in child executive functioning from 2 to 4 years, potential mechanisms such as displacement of parent-child interaction and executive function-building activities, and whether these effects are moderated by child sex or psychosocial stressors. The novel forms of media measurement used in this project – including mobile sampling and coding of interactive design affordances – will allow study results to reflect the complex ways in which modern media are used within families’ everyday lives.

PI_NAMEs: RADESKY, JENNY S (contact)

PROGRAM_OFFICER_NAME: GALLEN, COURTNEY LEIGH

PROJECT_TERMS: 2 year old;8 year old;Address;Adoption;Age;Algorithms;American;Articulation;Attention;attentional control;Behavior;Behavior Therapy;Cellular Phone;Child;Child Behavior;Child Development;Child Health;Child Rearing;Code;cognitive process;community advisory board;Complex;computer human interaction;Computers;design;Development;Devices;digital;digital media;Disadvantaged;early childhood;Education;Educational workshop;Emotional;Equation;evidence base;executive function;experience;Family;Frequencies;Guidelines;Habits;handheld mobile device;Home visitation;Hour;Household;Income;Individual;Informal Social Control;Interruption;Interview;Knowledge;Language;Learning;Life;Longitudinal cohort study;lower income families;Measurement;Measures;media use;Mediation;Modeling;Modernization;National Institute of Child Health and Human Development;novel;Nursery Schools;Outcome;Parent-Child Relations;Parents;Pathway interactions;Pediatric Research;Play;Policies;Population;Problem Solving;Psyche structure;Psychosocial Stress;psychosocial stressors;Recommendation;Regulation;Research;Resources;Rewards;Sampling;sex;Shapes;social media;Standardization;Stress;Structure;Surveys;Tablets;Technology;Television;Testing;Time;Toddler;touchscreen;tv watching;Video Recording;virtual

PROJECT_TITLE: Technology Use and Emerging Executive Functioning in Early Childhood

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: EY

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative The human visual system has the remarkable ability to quickly and ﬂexibly combine visual features, like shape and color, into the coherent objects that we perceive, enabling effective interaction with the world. In this project, we use state-of-the-art techniques in deep learning and neuroimaging to synthesize two inﬂuential theories for how the visual system accomplishes this feat. Understanding this fundamental visual operation will both en- able implementing it in useful machines, like self-driving cars, to improve public safety and industrial efﬁciency, and help develop treatments for patients with neurological deﬁcits in combining visual features (such as Balint's syndrome or visual agnosia).

PI_NAMEs: TAYLOR, JOHNMARK EDWARD (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Anatomy;Architecture;Artificial Intelligence;artificial neural network;Attention;Automobile Driving;Behavior;Biological;Brain;career;Code;Cognitive;cognitive neuroscience;Cognitive Science;Color;Complex;computational neuroscience;Computer Models;Computer Vision Systems;Crowding;Data Set;deep learning;deep neural network;Development;Disparate;Doctor of Philosophy;Endowment;Engineering;Environment Design;Exhibits;experience;experimental study;Feedback;flexibility;Functional Magnetic Resonance Imaging;Future;Glass;Homologous Gene;Human;human model;Image;improved;Industrialization;Influentials;Lateral;Learning;Link;Literature;Mentorship;Methodology;Methods;Modeling;Modernization;Natural experiment;neural;neuroimaging;Neurologic Deficit;Neurons;neurophysiology;Neurosciences;novel;object recognition;open source;operation;Patients;Population;presynaptic;Prevalence;Psychophysics;Recurrence;Research;response;Safety;Shapes;Stimulus;Sum;Syndrome;synergism;Techniques;Technology;Testing;theories;Toy;Training;ventral visual stream;Vision;vision science;Visual;Visual Agnosias;visual search;Visual System;Work

PROJECT_TITLE: Fast and Flexible Conjunction Coding in Biological and Artificial Vision


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROGRAM NARRATIVE Our Center is studying how immune responses in the lung result in production of excessive and abnormal mucus that plugs the airways and causes severe asthma. These studies will uncover new knowledge about mechanisms of asthma and help to pave the way for novel treatment approaches for this disease.

PI_NAMEs: ERLE, DAVID J (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;airway epithelium;airway hyperresponsiveness;airway obstruction;Allergic Disease;Asthma;Automobile Driving;biological adaptation to stress;bronchial epithelium;Bronchoscopy;Caspase;cell bank;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cell Separation;Cellular biology;Clinical;Clinical Research;Communication;Cystatins;cytokine;Data;Data Set;Development;Disease;endoplasmic reticulum stress;Ensure;Epithelial Cells;Epithelium;Family;Family member;Functional disorder;Gene Expression;genetic signature;Goblet Cells;Human;human model;human subject;Immune;Immune response;Impairment;Individual;inhibitor;insight;Interleukin-13;Knowledge;Lung;Measures;Mediating;Metaplasia;MicroRNAs;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;MUC5AC gene;Mucins;Mucociliary Clearance;Mucous body substance;National Institute of Allergy and Infectious Disease;new therapeutic target;novel;novel strategies;Pathogenesis;Pathologic;Pathology;Pathway interactions;prevent;Production;Productivity;Proteins;Regulation;Research;response;Role;Sampling Studies;Secretory Cell;Severities;Severity of illness;Specimen;Structure of parenchyma of lung;Therapeutic;Work

PROJECT_TITLE: Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Advisory Committees;airway epithelium;Allergic Disease;Asthma;Biocompatible Materials;Budgets;career;Clinical;Collaborations;Communication;Ensure;Expenditure;experience;Functional disorder;Funding;Funding Opportunities;Human Resources;Immune;Infrastructure;meetings;member;National Institute of Allergy and Infectious Disease;Preparation;programs;Progress Reports;Regulation;Research;Research Methodology;Research Personnel;symposium;synergism;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Administrative Core


ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed studies will reveal the extent to which viral peptides presented on the surface of HIV-infected cells stimulate natural killer (NK) cell responses through activating receptors and will provide an important proof-of-concept for the development of NK cell-based therapies to eradicate HIV-1 reservoirs in chronically infected individuals.

PI_NAMEs: BARKER, EDWARD ;EVANS, DAVID T (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Activated Natural Killer Cell;Adoptive Transfer;Agonist;Allogenic;Animals;Antibodies;Antibody Specificity;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;antiretroviral therapy;Autologous;Bar Codes;Binding;C Type Lectin Receptors;cancer cell;cancer immunotherapy;Cell Therapy;Cells;Cellular Assay;Chronic;Control Animal;Coupling;Development;Disease;Disease Progression;Effector Cell;Engineering;experimental study;FCGR3B gene;Genetic Polymorphism;Genotype;HIV;HIV-1;Human;Immunoglobulins;Individual;Infection;Killer Cells;KLRD1 gene;Ligands;Ligation;lymph nodes;Macaca;Macaca mulatta;Memory;MHC binding peptide;MHC Class I Genes;Molecular;Natural Killer Cells;NK cell therapy;Pathway interactions;Peptide/MHC Complex;Peptides;Persons;Plasma;Primates;Rapid screening;receptor;Receptor Cell;response;Rhesus;Role;Signal Transduction;SIV;Specificity;Surface;Testing;tumor;Viral;Viral Load result;viral rebound;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Harnessing adaptive NK cell transfer to deplete viral reservoirs


NIH_SPENDING_CATS: Asthma;Biomedical Imaging;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Lung

PI_NAMEs: BHAKTA, NIRAV RATI (contact)

PROJECT_TERMS: Airway Disease;airway epithelium;Applications Grants;Area;Asthma;Biological;Biological Specimen Banks;British Columbia;bronchial epithelium;Bronchoscopy;cell bank;Cells;Cellular Assay;Chronic Obstructive Pulmonary Disease;Clinical;Clinical Data;clinical phenotype;Clinical Research;clinically significant;Collection;Cryopreservation;Cytometry;Data;data submission;Databases;DNA;Enrollment;Ensure;Epithelial Cells;Epithelium;experience;experimental study;Functional disorder;Gene Expression Profiling;genomic data;Goals;Harvest;Human;human subject;human tissue;Image;Immune;Individual;insight;Institutional Review Boards;Link;Lung;Lung Diseases;Measures;Messenger RNA;Methods;MicroRNAs;Molecular;Mucous body substance;National Institute of Allergy and Infectious Disease;novel;Participant;Pathology;Pathway interactions;Performance;Process;Proteins;Protocols documentation;recruit;Registries;Regulation;Research;Research Personnel;Resources;RNA;Sampling;Secure;single-cell RNA sequencing;Source;Specimen;Structure of parenchyma of lung;success;System;Tissue Banks;tissue registry;Translational Research;Universities;Work;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Subject and Biospecimen Core


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Burden of Illness;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Effect of Hearing Aid Insurance Coverage Requirements for Adults on Utilization Project Narrative The proposed research is relevant to public health because it will estimate the effect of hearing aid coverage requirements on hearing aid use. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to protecting and improving health.

PI_NAMEs: PESKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Accounting;Address;Adopted;Adoption;Adult;Affect;Age;aged;Area;Audiology;Awareness;barrier to care;beneficiary;burden of illness;Clinical;Communication;Control Groups;cost;Cost Sharing;Data;Deductibles;disability-adjusted life years;Disparity;disparity reduction;dual eligible;Ear;Economics;Education;efficacious treatment;Electronics;Eligibility Determination;ethnic minority;Ethnic Origin;Evaluation;Federal Government;Frequencies;Goals;Health;health care availability;Health Care Research;health care service utilization;health economics;Health Insurance;health plan;Health Policy;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing loss treatment;improved;Individual;innovation;Insurance;Insurance Benefits;Insurance Claim Review;insurance claims;Insurance Coverage;insurance plan;Interdisciplinary Study;Link;Low income;male;Medicaid;Medicare;Methods;Mission;Modeling;Modification;National Health Interview Survey;normal hearing;Outcome;payment;Policies;Policy Research;Population;Privatization;programs;Public Health;public health insurance;Quality of life;Quasi-experiment;Race;racial minority;Reporting;Reproducibility;Research;Services;sex;sound;Source;State Government;Statistical Models;Statutes and Laws;Subgroup;Surveys;System;treatment effect;Unemployment;United States National Institutes of Health;uptake;Variant

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Asthma;Biotechnology;Lung

PROJECT_TERMS: Affect;airway epithelium;airway hyperresponsiveness;airway obstruction;Asthma;asthma model;Automobile Driving;Award;Biochemical;bronchial epithelium;Caspase;Cathepsins;Cell Culture Techniques;Cell fusion;Cell Physiology;Cells;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;cystatin SN;Cystatins;Cysteine Proteinase Inhibitors;cytokine;Data;dietary;Epithelial Cells;epithelial Na+ channel;Epithelium;Equilibrium;Exocytosis Induction;Exposure to;Family;Flow Cytometry;Functional disorder;Gene Targeting;Genes;genetic signature;Genetic Transcription;Goblet Cells;Grant;Host Defense;Human;Hydration status;Immune;Immune response;Impairment;improved;in vitro Assay;in vivo;Individual;Inflammation;inhibitor;Integral Membrane Protein;Interleukin-13;Lung;Measures;Mediating;member;Membrane Proteins;Metaplasia;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;MUC5AC gene;Mucins;Mucociliary Clearance;Mucous body substance;Mus;novel;pathogen;Pathway interactions;Physiological;Play;Population;prevent;Production;Protease Inhibitor;protein transport;Proteins;response;Role;Secretory Cell;Secretory Vesicles;Severity of illness;Signal Induction;Signal Transduction;single-cell RNA sequencing;Site;Source;Specimen;Testing;Therapeutic;tool;Work

PROJECT_TITLE: Project 1: Novel mechanisms driving mucin secretion and mucus plugging in type 2-high asthma


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative There is strong interest in utilizing oxytocin as a therapeutic for psychiatric disorders, yet the neural circuits underlying oxytocin action are poorly defined. The proposed experiments use rodent models to examine oxytocin neural circuits that mediate social anxiety and social approach.

PI_NAMEs: TRAINOR, BRIAN C (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Affect;Agonist;Animals;antagonist;Antisense Oligonucleotides;Anxiety Disorders;authority;Behavior;Behavioral;behavioral study;Bioinformatics;Brain region;California;Cells;Characteristics;Coupling;Data;Data Set;Development;Dose;Electrophysiology (science);experimental study;Female;GTP-Binding Proteins;Human;Hypothalamic structure;Impairment;Individual;Infusion procedures;innovation;insight;interest;male;Mediating;men;Mental disorders;mesolimbic system;Modeling;Molecular;Molecular Analysis;molecular phenotype;multidisciplinary;Mus;neural circuit;Neurons;Neuropeptides;novel;novel therapeutic intervention;Nucleus Accumbens;Oxytocin;Oxytocin Receptor;paraventricular nucleus;Participant;Pathway interactions;Performance;Pharmacology Study;Phenotype;Physiological;Population;Potassium Channel;receptor coupling;reduce symptoms;Reporting;Research;response;Rodent Model;Schools;sex;Sex Differences;Signal Pathway;Signal Transduction Pathway;single cell analysis;single-cell RNA sequencing;skills;social;social anxiety;Social Anxiety Disorder;Social Behavior;Social Controls;social defeat;Social Environment;Social Interaction;Social Phobia;social relationships;social stress;Stress;Structure of terminal stria nuclei of preoptic region;System;Testing;Therapeutic;therapeutic target;tool;Transcript;United States;vigilance;Viral;Viral Vector;Virus;Visualization;Woman;women versus men;Women's prevalence;Work

PROJECT_TITLE: Oxytocin-dependent circuits of social approach and vigilance

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Bioengineering;Cancer;Kidney Disease;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: Project Narrative Acute kidney injury (AKI) is a global public health concern impacting about 13 million patients every year, and currently has no FDA-approved drugs for its prevention or treatment. Therefore, there is a great need for developing effective therapies for AKI that is associated with high morbidity and mortality. The proposed research is relevant to public health as it will develop novel therapeutic intervention that can treat AKI whose pathogenesis involves activation of inflammatory and apoptotic pathways.

PI_NAMEs: ARORA, MEENAKSHI ;MAJETI, RAVIKUMAR N (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Abbreviations;Acute Renal Failure with Renal Papillary Necrosis;Address;Adjuvant;age related;Animals;Anti-Inflammatory Agents;Antioxidants;Apoptotic;Attenuated;Benchmarking;Biological Availability;Blood Vessels;cancer cell;Cancer Patient;cancer therapy;canine model;Canis familiaris;Carbon;Carcinoma;Characteristics;chemotherapy;Cisplatin;Clinic;Clinical;Clinical Research;clinical translation;combination cancer therapy;comparative;cost;Cytotoxic agent;Data;density;design;Development;Disease;dosage;Dose;Drug Kinetics;effective therapy;Elements;Ellagic Acid;Encapsulated;Etiology;Excretory function;FDA approved;Formulation;Functional disorder;Generations;glomerular filtration;Goals;Human;Impairment;improved;Individual;Inflammatory;intestinal barrier;Kidney Diseases;Knowledge;Laboratory Study;Length;Length of Stay;Ligands;Literature;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Methods;microbial;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;nanoparticle;nanopolymer;Neoplasm Metastasis;neuroinflammation;novel therapeutic intervention;Nucleosome Core Particle;Oncology;Oral;Outcome;particle;Pathogenesis;Pathway interactions;Patients;Performance;Periodicals;Peritoneal;pet animal;Pharmaceutical Preparations;Pharmacology;Polyesters;Prevention;Public Health;Reactive Oxygen Species;receptor;Regimen;Renal function;Research;research clinical testing;Resistance;Rodent;Safety;side effect;Speed;success;Surface;Syndrome;System;Testing;TFRC gene;Therapeutic;therapeutic nanoparticles;therapeutic target;therapy outcome;Tissues;Transferrin;Tubular formation;tumor;Unresectable;uptake;urinary;Work

PROJECT_TITLE: Urolithin A nanoparticle therapy for acute kidney injury

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: NARRATIVE Pulmonary fibrosis, the scarring process of the lung, is usually irreversible and potentially fatal. We propose experiments to determine how mechanical properties of the fibrotic environment modulate macrophage phenotype/immunity through metabolic reprogramming. These studies will lead to a greater understanding of the development of pulmonary fibrosis and provide novel therapeutic targets for drug development.

PI_NAMEs: HE, CHAO  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Acclimatization;Adult;Animals;arginase;Attenuated;Biochemical;Biology;career development;Cell Physiology;Cell surface;Characteristics;Chronic;Cicatrix;Communication;cytokine;Data;Development;Development Plans;Disease;drug development;Environment;Etiology;experience;experimental study;extracellular;Extracellular Matrix;fatty acid oxidation;Fibrosis;fibrotic lung;fibrotic lung disease;Growth;human old age (65+);human subject;idiopathic pulmonary fibrosis;Immunity;in vivo;Integrin alphaVbeta3;Integrins;Interleukin-4;Interruption;ITGB3 gene;Knowledge;Lung;lung health;Macrophage;Macrophage Activation;mechanical properties;mechanical signal;mechanotransduction;Mediating;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;monocyte;mouse model;multidisciplinary;Mus;new therapeutic target;novel;Older Population;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Phenotype;Physicians;PPAR gamma;Prevalence;Process;Pulmonary Fibrosis;Research;Research Proposals;Role;Scientist;Series;Signal Transduction;skills;Stimulant;targeted treatment;Testing;Training;transcription factor

PROJECT_TITLE: Mechanosignaling regulates macrophage immunometabolism

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This project seeks to identify novel positive and negative regulators of protection against Mycobacterium tuberculosis, the single deadliest pathogen in the world. Leveraging exciting preliminary data of Mtb-infected lungs analyzed by single cell RNA-sequencing, this project will identify pathways used by macrophages to restrict tuberculosis growth, as well as identify the mechanism by which neutrophils inhibit productive responses against this infection. Discovering new immune regulators of tuberculosis control will provide targets for host-directed therapies, which are in dire need due to lack of an efficacy vaccine and extremely long antibiotic treatment course for tuberculosis.

PI_NAMEs: KOTOV, DMITRI I (contact)

PROJECT_TERMS: acute infection;anakinra;antagonist;Anti-Bacterial Agents;Antibiotic Therapy;Autoimmune Diseases;Bacteria;Biological Response Modifiers;Bone Marrow;candidate identification;Cause of Death;Cells;Cessation of life;Chimera organism;Chronic;Clinical Trials;Communication;cytokine;Cytoprotection;Data;Data Set;Development;Disease;enhancing factor;Environment;experimental study;Gene Expression;Genes;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Health;Hematopoietic;Heterogeneity;Host Defense;Human;IL18 gene;IL1R2 gene;Immune;Immune response;Immunologic Factors;Immunosuppression;in vivo;in vivo evaluation;Incidence;Individual;Infection;Infection Control;Inflammatory;inflammatory milieu;inhibitor;insight;Interleukin-1;Interleukin-1 Receptors;interleukin-22;Knowledge;Laboratories;Lung;Macrophage;Mediating;mortality;Mouse Strains;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;neutrophil;Neutrophilia;novel;novel strategies;pathogen;Pathway interactions;Population;Predisposition;Production;Productivity;programmed cell death protein 1;protective effect;protective factors;receptor;Research Design;resistant strain;response;restraint;Role;sensor;Series;Signal Transduction;single-cell RNA sequencing;success;T cell response;Testing;Therapeutic;Time;TNF gene;Tuberculosis;tuberculosis treatment;vaccine efficacy;vaccine strategy;Vaccines

PROJECT_TITLE: In vivo mechanisms of Mycobacterium tuberculosis control and susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


PI_NAMEs: WOODRUFF, PRESCOTT G (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Air;airway epithelium;airway inflammation;alveolar epithelium;Asthma;Basal Cell;Cell Degranulation;Cell Differentiation process;Cells;Complex;cytokine;Data;Disease;Dose;endoplasmic reticulum stress;Endoribonucleases;Epithelial Cells;Epithelium;Family;Family member;fibrotic lung disease;Functional disorder;Funding;Gel;Generations;Glycoproteins;Goblet Cells;Homeostasis;Human;Immune;in vivo;Individual;Inflammation;Inhalation;inhibitor;Injury;Interleukin-13;kinase inhibitor;Liquid substance;Mediating;member;Metaplasia;MicroRNAs;Molecular;MUC5AC gene;Mucins;Mucous body substance;mucus-associated lung diseases;Mus;novel;novel therapeutic intervention;novel therapeutics;Oligonucleotides;Outcome;Output;Pathologic;Pathway interactions;Patients;Phosphotransferases;Play;pre-clinical;preservation;prevent;Process;Production;Proteins;pulmonary function;Regulation;response;Role;Secretory Cell;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;small molecule;small molecule inhibitor;Testing;Therapeutic;tool;transdifferentiation;Transitional Cell;Work

PROJECT_TITLE: Project 2: Micro-RNA and ER stress regulation of pathological mucus in type 2-high asthma


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative Spinal motoneurons are the final common pathway to all movement and receive 30-50,000+ synapses per cell, majority of which come from pre-motor interneuronal networks. Peripheral nerve injury promotes plasticity of spinal circuits resulting in persistent motor deficits such as a loss in the stretch reflex and muscle co-contraction. The objective of this award is to investigate two sources of circuit dysregulation that impact motor performance following axotomy: aberrant synaptogenesis in the deep dorsal horn and the loss of presynaptic inhibition on propriosensors.

PI_NAMEs: ROTTERMAN, TRAVIS MICHAEL (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Anatomy;antagonist;Anterior;arm;Award;Axon;axonal degeneration;Axotomy;behavioral response;cell type;Cells;Central Nervous System;comparison control;Crush Injury;density;designer receptors exclusively activated by designer drugs;Development;disease model;Distal;dorsal horn;Electric Stimulation;Environment;Excision;experience;experimental study;Fire - disasters;Gastrocnemius Muscle;Generations;Genes;Genetic;Glutamates;Goals;Hyperreflexia;Implant;in vivo;Individual;Injury;Interneurons;Joints;Knowledge;Limb structure;Maps;Medial;Motion;Motor;motor control;motor deficit;Motor Neurons;Motor Pathways;mouse model;Movement;multi-electrode arrays;Muscle;Muscle Spindles;Natural regeneration;Nerve;Nerve Crush;nerve injury;nerve transection;Nervous System;neural;neural network;neurobiotin;Neurons;Pathway interactions;Patients;Performance;Peripheral;peripheral nerve damage;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System;Phenotype;Physiological;Population;preservation;presynaptic;prevent;Process;Production;Proprioceptor;receptor;Recovery;recruit;Reflex action;reinnervation;response;Robotics;Sensory;sensory feedback;Site;skills;Source;Spinal;Spinal Cord;stem;stretch reflex;Stretching;Synapses;synaptic inhibition;Synaptic Transmission;synaptogenesis;Testing;Transgenic Mice;Transgenic Model;Ventral Horn of the Spinal Cord;Work

PROJECT_TITLE: Plasticity of spinal neural networks directly impacts motor control following peripheral nerve injury

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE RNA oxidation precedes motor neuron degeneration in ALS, yet its consequences in the context of disease are not understood. This project seeks to identify the effects of RNA oxidation on several aspects of RNA processing and the cellular mechanisms by which it might lead to neuronal death. If successful, this work will clarify the molecular mechanisms underlying RNA oxidation and identify potential therapeutic intervention strategies.

PI_NAMEs: CHAIM, ISAAC ALEXANDER (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Acceleration;activation-induced cytidine deaminase;Aging;Amyotrophic Lateral Sclerosis;Amyotrophic Lateral Sclerosis Pathway;Biotechnology;cell injury;cell type;Cells;Computing Methodologies;diagnostic strategy;Disease;Disease Progression;DNA;DNA Damage;DNA Repair;Environment;Faculty;familial amyotrophic lateral sclerosis;Genes;Genetic Transcription;high risk population;In Vitro;induced pluripotent stem cell;insight;Intervention;Link;Location;Mentors;Methods;Modeling;Molecular;motor neuron degeneration;Motor Neurons;mouse model;mutant;Mutation;Nerve Degeneration;neuron loss;Neurons;novel;Organoids;oxidation;Oxidative Stress;Pathogenesis;Patients;Positioning Attribute;programs;Proteins;Reactive Oxygen Species;Regulation;Research;Research Institute;Research Personnel;Resolution;response;RNA;RNA immunoprecipitation sequencing;RNA Processing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Specimen;Spinal;Spinal Cord;sporadic amyotrophic lateral sclerosis;Testing;Therapeutic Intervention;Tissues;Training;Transcript;transcriptomics;Translations;Work

PROJECT_TITLE: Elucidating the role of RNA oxidation on amyotrophic lateral sclerosis onset and progression


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Rehabilitation;Rehabilitation

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Motor impairments are among the most debilitating symptoms in a wide range of neurodegenerative disorders, including Parkinson's disease. This project will determine the role of distinct subpopulations of neurons in parafascicular (PF) thalamus in regulating locomotion and motor learning processes, which are commonly disrupted in movement disorders. By characterizing the dysfunction of PF subpopulations in a mouse model of Parkinson's disease, this project will identify PF circuit manipulations capable of treating multiple motor phenotypes.

PI_NAMEs: ROY, DHEERAJ  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Basal Ganglia;Basic Science;Behavior;Behavioral;Biological Assay;Brain region;Calcium;career development;Complex;Corpus striatum structure;Data;debilitating symptom;Deep Brain Stimulation;Defect;Development Plans;Disease;disease model;Dorsal;Electrophysiology (science);Exhibits;experimental study;frontal lobe;Functional disorder;Future;Genetic;Gilles de la Tourette syndrome;Globus Pallidus;Heterogeneity;Human;Huntington Disease;Image;in vivo;in vivo calcium imaging;innovation;learned behavior;Life;Locomotion;Mediating;Mentors;Molecular Target;Motor;motor behavior;Motor Cortex;motor deficit;motor disorder;motor impairment;motor learning;Motor Skills;motor symptom;mouse model;Movement;Movement Disorders;Mus;Muscarinic Acetylcholine Receptor;neural;neural circuit;Neurodegenerative Disorders;Neurons;optogenetics;Parkinson Disease;Pathway interactions;Pattern;Phase;Phenotype;Play;Process;programs;putamen;Rattus;Receptor Activation;Reporting;Research;research and development;Research Personnel;response;Reversal Learning;Role;single-cell RNA sequencing;skill acquisition;Structure of subthalamic nucleus;Substantia nigra structure;System;Testing;Thalamic Nuclei;Thalamic structure;Therapeutic;tool;Wild Type Mouse

PROJECT_TITLE: Determining the Role of Distinct Parafascicular Thalamic Circuits in Motor Behaviors Relevant to Parkinson’s Disease


ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Neuromodulation is a biomedical technology that acts directly upon nerves by delivering an electrical stimulus, chemical agent, or energetic wave to a target neuroanatomical site. Of the various forms in clinical use or development, ultrasound neuromodulation is an appealing modality because it uninvasively combines high spatial resolution and depth with the ability to physiologically modulate excitable cells in endogenous and genetically modified tissues. Fundamental knowledge on the biophysical mechanisms of the actuators utilized in ultrasound neuromodulation—mechanosensitive ion channels—will aid in modulating cellular electrical excitability, engineering sonogentic tools, and translating laboratory findings to a clinical setting to help promote a modern era of minimally invasive ultrasound-based neuromodulatory treatments.

PI_NAMEs: SORUM, BEN  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acoustics;Action Potentials;Address;Architecture;Area;Axon;Behavior;Biological;Biomedical Technology;Biophysical Process;Biophysics;bone;Brain;Brain imaging;Calcium;Calcium Binding;Cell Line;Cell membrane;Cells;Cephalic;Chemical Agents;Clinical;Cultured Cells;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Development;Electrophysiology (science);Engineering;experimental study;FDA approved;fluorophore;Focused Ultrasound;Gene Modified;Genetic;Goals;hippocampal pyramidal neuron;Hybrids;Image;In Vitro;in vivo;Ion Channel;Ions;Knowledge;Laboratory Finding;Light;Lipids;mechanical energy;Mechanics;Membrane;Membrane Lipids;Mentors;minimally invasive;Modality;Modeling;Modernization;Molecular;Motion;Mus;Mutagenesis;Mutate;Nature;Nerve;neural;neural circuit;Neuroanatomy;neuronal excitability;Neurons;neurophysiology;neuroregulation;Neurosciences;novel;optogenetics;Penetration;Permeability;Phase;Physiological;Physiology;Potassium Channel;programs;Proteins;proteoliposomes;Protocols documentation;Radial;Ranvier's Nodes;reconstitution;Research;Resolution;response;Signal Transduction;Site;skills;Slice;sound;Stimulus;Structure;Surveys;System;Techniques;Testing;Time;Tissues;tool;Training;trait;transgene expression;Translating;Ultrasonic wave;Ultrasonics;ultrasound;Validation;white matter;Work;Xenopus oocyte

PROJECT_TITLE: Ultrasonic modulation of cellular electrical signaling


ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative This proposal seeks to characterize how different combinations of transcription factors in neurons instruct them to acquire their cell-type specific morphology, connectivity and physiology during development. Understanding the regulatory mechanisms that underlie neuronal diversity of the visual circuits will enable adult or induced stem cells to be differentiated into neurons that can precisely and predictably integrate into existing neural circuits, and will provide new approaches to treat blindness, brain injury and neurodegeneration. Through computational modeling of gene regulatory networks, the project aims to discover new molecular mechanisms that mediate synapse-specific wiring of the brain, which will help the development of effective treatments for a variety of neurodevelopmental disorders.

PI_NAMEs: OZEL, MEHMET NESET  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Affect;Algorithms;ATAC-seq;Award;Biological Models;Blindness;Brain;Brain Injuries;Brain region;Calcium;Candidate Disease Gene;cell replacement therapy;Cell Surface Proteins;cell type;Cells;Chromatin;Code;Collaborations;Complex;Computational Technique;Computer Models;Data;Data Set;Decision Making;Defect;Detection;Development;Developmental Gene;Drosophila genus;effective therapy;Electrophysiology (science);Enabling Factors;Engineering;Environment;Equilibrium;experimental study;fly;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic study;Genetic Transcription;Goals;Human;Image;improved;in vivo;in vivo calcium imaging;Individual;induced pluripotent stem cell;interest;Knowledge;Lead;Learning;Link;Logic;machine learning framework;Mediating;Mentors;Mentorship;Methods;model building;Modeling;Modification;Molecular;Morphology;Motion;Nerve Degeneration;nerve stem cell;Nervous System;network models;neural;neural circuit;Neurodevelopmental Disorder;neuron development;Neurons;Neurophysiology - biologic function;neuroregulation;New York;novel strategies;Optic Lobe;Output;Phase;Physiological;Physiology;postmitotic;postsynaptic;Process;programs;Property;Regenerative Medicine;Research;Resources;response;Retina;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Specific qualifier value;Specificity;stem cells;Synapses;synaptogenesis;System;Techniques;Testing;Time;tool;Training;transcription factor;transcriptome;transdifferentiation;Transplantation;Universities;Visual;Visual System;Work

PROJECT_TITLE: Gene Regulatory Networks of Synaptic Specificity


ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Temporal lobe epilepsy is highly refractory to drug treatment and, when possible, requires surgical removal of the “focus”, which is still unsuccessful in many cases. The proposed experiments employ cutting-edge techniques to determine if the “focus” actually involves more distributed brain networks, offering a potential explanation for the failure of invasive surgeries. Looking towards future therapies, this project tests whether non- invasive neuromodulation with ultrasound, focused on a key node of this extended network, is able to control seizures.

PI_NAMEs: FARRELL, JORDAN STEWART (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adult;Anterior;Anterior Nuclear Group;Automobile Driving;Back;Biological;Brain;calbindin;career development;Cell Nucleus;cell type;Cells;Chronic;cingulate cortex;clinical translation;Clinical Trials;clinically relevant;Collaborations;Coupled;Data;Deep Brain Stimulation;density;Devices;Drug resistance;Electrophysiology (science);entorhinal cortex;Epilepsy;epileptiform;Event;Excision;experience;experimental study;Failure;Fiber;Focal Seizure;Focused Ultrasound;Future;Goals;Grant;High Frequency Oscillation;Hippocampus;Hypothalamic structure;in vivo;in vivo calcium imaging;Innovative Therapy;kainate;Knowledge;Label;Laboratories;Life;Mammillary body structure;Medial;Memory;Mentors;miniaturize;Modality;Modeling;Mus;neural;neural network;Neurons;neuroregulation;Neurosciences;Neurotensin;novel therapeutics;Operative Surgical Procedures;optogenetics;Output;Partial Epilepsies;Pathologic;Pathway interactions;Persons;Pharmaceutical Preparations;Pharmacotherapy;Photometry;Physiological Processes;Pilocarpine;Play;Positioning Attribute;Postdoctoral Fellow;postsynaptic;programs;recruit;Recurrence;Refractory;Research;Research Training;Resected;Resources;Role;Seizures;Source;Specificity;support network;Synapses;technique development;Techniques;Temporal Lobe Epilepsy;Testing;Thalamic structure;timeline;tool;Training;Transgenic Mice;Translations;ultrasound;Universities;Work

PROJECT_TITLE: Dissecting Hypothalamic Pathways for Seizure Control


NIH_SPENDING_CATS: Arthritis;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Osteoarthritis;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Knee and limb underloading are ubiquitous after anterior cruciate ligament (ACL) reconstruction and fails to resolve with the standard of care rehabilitation. This underloading behavior is clinically concerning and considered maladaptive, as it affects patient function, has been linked to risk for re-injury, and appears to be a precursor for post-traumatic knee osteoarthritis that affects upwards of 50% of patients who undergo an ACL reconstruction. This application will lay the foundation for a novel split-belt training paradigm to improve knee and limb loading after ACL reconstruction by identifying the optimal split-belt treadmill training parameters to elicit both acute and long-term improvements in loading mechanics.

PI_NAMEs: KRISHNAN, CHANDRAMOULI ;PALMIERI-SMITH, RIANN MARIE (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Acute;Adherence;Affect;Amendment;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Behavior;Bilateral;Biological Markers;Biomechanics;Cartilage;Clinical;Clinical Research;Clinical Trials;cost;Data;design;Development;driving force;Educational Intervention;effective intervention;Enrollment;Foundations;Future;Gait abnormality;Grant;Health;Impairment;improved;Individual;Injury;innovation;instrument;Intervention;Knee;Knee joint;Knee Osteoarthritis;Leg;life time cost;Limb structure;Link;Logistics;mechanical load;Mechanics;Mediating;Michigan;Modeling;Motion;Neurologic;novel;Operative Surgical Procedures;Outcome;Participant;Patient Recruitments;Patients;Pattern;Placebos;Population;preservation;Randomized;randomized, clinical trials;Reaction;Reconstructive Surgical Procedures;Recording of previous events;Rehabilitation therapy;rehabilitative care;Reporting;Research;Risk;Running;Speed;standard of care;Testing;therapeutically effective;Time;Training;Training Programs;Traumatic Arthropathy;treadmill;treadmill training;Treatment Efficacy;treatment strategy;Walking

PROJECT_TITLE: Mi-SPA: Michigan Split-belt Adaptation Paradigm to Improve Knee Loading After Anterior Cruciate Ligament Reconstruction

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Many trainees express an interest in research during residency training, but clinical demands limit the opportunity to engage in meaningful, longitudinal investigations and/or to acquire the fundamental skillsets that build the foundation of a clinician-investigator career. The overarching goal of the Pittsburgh Innovation in Collaborative Training of Residents Alliance, or PICTOR Alliance program, is to recruit, retain and accelerate independence of a pool of resident-investigators to perform basic translational and clinical translational research using a highly integrative approach that draws upon the experience of a diverse group of established investigators within four clinical departments (Medicine, Pathology, Pediatrics, and Surgery) focused on heart, lung, blood, and sleep research.

PI_NAMEs: DELA CRUZ, CHARLES S (contact);MORRIS, ALISON

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Acceleration;Adopted;Adult;Aging;Ally;American Medical Association;Area;Award;Biological Sciences;Biometry;Blood;career;career development;Childhood;Clinical;Clinical Medicine;clinical training;clinical translation;cohort;Collaborations;Collection;Competence;Cost Sharing;COVID-19 pandemic;Creativeness;Data;Dedications;design;Discipline;Disease;Disproportionately impacts women;Doctor of Philosophy;Education;Educational process of instructing;experience;Exposure to;Extramural Activities;faculty mentor;Foundations;Funding;Future;Goals;Grant;Grooming;Growth;Health;Heart;Immersion;Individual;Infrastructure;innovation;Institution;interest;Investigation;investigator training;Laboratories;Leadership;Learning;life span;Lung;matriculation;medical schools;Medicine;member;Mentors;Mentorship;Methodology;Mission;National Heart, Lung, and Blood Institute;next generation;novel strategies;Operative Surgical Procedures;Outcome;Pathology;Pathway interactions;Pediatrics;peer;Physicians;pre-clinical;Problem Solving;programs;promote resilience;Qualifying;Recording of previous events;recruit;Reporting;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Residencies;Respondent;Schedule;Science;Scientist;Self-reflection;skills;Sleep;Strategic vision;Structure;Supervision;Surveys;Taxes;Teacher Professional Development;Time;Training;Training and Education;training opportunity;Training Programs;Training Support;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Women's Group;working group

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O2)]


ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative: Successful completion of this project will enhance our understanding of the impact of cardiac aging on the N-cadherin-catenin-vinculin-actin mechanotransduction pathway, which will facilitate the design of novel therapeutic strategies to prevent adverse cardiac aging in healthy patients, and to improve function in heart failure patients.

PI_NAMEs: RADICE, GLENN LAWRENCE (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Acceleration;Actins;Action Potentials;Adherens Junction;Adhesions;Affect;Age;age acceleration;age related;aged;Aging;aging population;Atrial Fibrillation;Biological Models;Cardiac;cardiac aging;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cells;Chronic Myeloid Leukemia;Complex;Connexins;coronary fibrosis;Coupling;Cytoskeletal Proteins;Cytoskeleton;Defect;design;Drosophila genus;effective intervention;Elderly;Energy Metabolism;experience;fitness;fly;Framingham Heart Study;functional decline;Functional disorder;functional improvement;Generations;Gleevec;healthy aging;Heart;Heart Atrium;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Hypertrophy;Imatinib;improved;inhibitor;insight;Intercellular Junctions;Intervention;life span;Link;Longitudinal Studies;Macaca mulatta;Maps;mechanical force;Mechanics;mechanotransduction;Mediating;Membrane;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant mouse model;Myocardial dysfunction;Myocardium;N-Cadherin;Natural regeneration;novel therapeutic intervention;older adult;older patient;Optics;overexpression;Participant;Pathway interactions;Patients;Pattern;Phosphorylation;Phosphotransferases;Physiological;Play;Predisposing Factor;Prevalence;prevent;Proteins;Quality of life;Rattus;Regulation;Resistance;response;Risk Factors;Role;Sarcomeres;Structure;Sudden Death;Testing;Thick;Translating;transmission process;Tyrosine Phosphorylation;Up-Regulation;Vinculin

PROJECT_TITLE: Regulation of Mechanical Coupling in Aging Myocardium

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE This pilot project seeks to test the Promoting Positive Care Interaction (PPCI)—a theory-based four-step intervention including: 1) stakeholder engagement in developing facility specific goals; (2) environment and policy assessments; (3) flexible staff education; and (4) ongoing mentorship, motivation, and support (in- person visits and text messages) for staff in an effort to find the most effective way to improve daily care interactions between staff (nursing, activity, housekeeping, and dining service) and residents with Alzheimer’s disease and related dementias (ADRD) in Assisted Living Facilities (ALFs). The proposed study will specifically help us to: 1) understand whether the four steps of PPCI can be conducted as planned, and 2) determine whether PPCI can improve selected resident outcomes (quality of life, agitation, and resistiveness to care), staff outcomes (quality of care interactions, knowledge, perceived competence related to care and communication, stress, and relationship quality), and organizational outcomes (environment and policies). This information will guide the future implementation of PPCI on a larger scale to further improve daily care interactions in ALFs and promote resident and staff well-being.

PI_NAMEs: PAUDEL, ANJU  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: acceptability and feasibility;Address;Affect;Age;Agitation;Alzheimer's Disease;Alzheimer's disease related dementia;Antipsychotic Agents;Area;Assisted Living Facilities;Bathing;Behavior;Behavioral;Behavioral Symptoms;Caring;Cluster randomized trial;common symptom;Communication;communication behavior;Communication difficulty;Competence;cost;COVID-19 pandemic;Cues;Data;Dementia;dementia care;design;Discipline of Nursing;Distress;Education;efficacy testing;Enrollment;Environment;evidence base;falls;Female;flexibility;Focus Groups;Frustration;functional decline;Future;future implementation;Goals;Hospitalization;Housekeeping;improved;improved outcome;Individual;Infrastructure;Intervention;Intervention Studies;Knowledge;Licensing;Long-Term Care;Measures;Mentors;Mentorship;Methods;Modeling;Motivation;Noise;non-verbal;Not Hispanic or Latino;Nursing Homes;Outcome;Personal Satisfaction;Persons;Pilot Projects;pilot test;Policies;Population;preference;Prevalence;Promoting Action on Research Implementation in Health Services framework;Quality of Care;Quality of life;racial minority;recruit;Resources;response;retention rate;Risk;role model;Safety;Sampling;Self Management;Services;skills;social;social cognitive theory;Standardization;Stress;Surveys;systemic barrier;Testing;Text Messaging;theories;Touch sensation;Training;verbal;Visit;Work

PROJECT_TITLE: Optimizing the Daily Care Interactions Between Direct Care Staff and Assisted Living Residents with Dementia

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Cannabidiol Research;Cannabinoid Research;Cardiovascular;Natural Products;Opioid Misuse and Addiction;Opioids;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Opioid misuse and abuse are a rapidly evolving public health crisis. The proposed research could improve our knowledge of a potentially effective medication for heroin-induced adverse effects in nonhuman primate models. If proposed aims are achieved, this project will facilitate design of new treatment options that can ameliorate adverse consequences of using opioids afflicting a large population worldwide.

PI_NAMEs: KO, MEI-CHUAN  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: abuse liability;Advanced Development;Adverse effects;adverse outcome;Affect;Agonist;Analgesics;antagonist;Attention;Attenuated;awake;Behavior;Behavioral;Behavioral Assay;behavioral pharmacology;behavioral response;Biological Assay;blood pressure reduction;Buprenorphine;Cannabidiol;Cannabis;Cardiovascular system;Clinical;Communities;comparative efficacy;comparison control;Cues;Data;design;Devices;Dose;Economic Burden;Effectiveness;Evaluation;Food;Future;Goals;Heart Rate;Heroin;Human;human study;Hypotension;illicit opioid;improved;Intervention;Knowledge;Ligands;Measurement;Medical;medication for opioid use disorder;Modeling;mortality;Naltrexone;non-drug;nonhuman primate;Opioid;opioid abuse;opioid epidemic;opioid misuse;opioid overdose;Opioid Peptide;Opioid Receptor;opioid use;opioid use disorder;Peptide Receptor;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Phylogenetic Analysis;Physiological;Population;preclinical study;Primates;Psychological reinforcement;Public Health;receptor function;reinforcer;Research;respiratory;Rodent;Safety;Self Administration;side effect;Societies;Telemetry;temporal measurement;Testing;Therapeutic;therapeutic opioid;Ventilatory Depression

PROJECT_TITLE: Functional efficacy of cannabidiol in modulating the adverse effects of heroin in primates.


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Biotechnology;Emerging Infectious Diseases;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Regenerative Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE There is an urgent need to give long-term protection for immunocompromised patients from Candidiasis. The proposed cell-based therapies will give long-term protection and give new hope to treat drug resistant Candida spp. Thus, this proposal is relevant to part of of supporting research to improve human health.

PI_NAMEs: KUMAR, PAPPANAICKEN RANGASAMY (contact)

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Adaptive Immune System;Adverse effects;Age Years;Allogenic;anti-fungal agents;Antibodies;Antigens;antimicrobial;Aspergillus;Biological Assay;Biomedical Engineering;cancer therapy;Candida;Candida albicans;Candida glabrata;Candidiasis;CAR T cell therapy;CD28 gene;CD3 Antigens;Cell secretion;Cell Therapy;Cell Wall;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinical;Coculture Techniques;congenital immunodeficiency;Cross Presentation;cytokine;Cytoplasmic Granules;Cytoplasmic Tail;Death Rate;dectin 1;Development;Disseminated candidiasis;Drug resistance;efficacy study;Epidermal Growth Factor Receptor;Extracellular Domain;Fungal Drug Resistance;fungicide;Generations;Goals;granulocyte;Growth;Growth Factor;gut microbiota;Health;Hematologic Neoplasms;Human;Hyphae;Image;Immune Evasion;Immune system;Immunocompromised Host;immunological status;improved;In Vitro;in vivo;Induction of Apoptosis;Infection;Inflammatory;Infusion procedures;Life;Ligands;Macrophage;Microscope;Molecular Biology;Monitor;mouse dectin-2;mouse model;Mus;mutant;Nosocomial Infections;novel;novel therapeutics;Opportunistic Infections;opportunistic pathogen;Organ Transplantation;Outcome;pathogen;pathogenic microbe;Patients;Pattern recognition receptor;Phagocytosis;Pharmaceutical Preparations;preclinical study;Predisposition;promoter;receptor;Receptor Activation;recruit;Research;Research Support;Resistant candida;Safety;Scanning;side effect;Solid;success;System;T-Cell Receptor Therapy;T-Lymphocyte;Testing;therapy design;Time;time use;timeline;Tissue Culture Techniques;Toxic effect;treatment strategy;Validation;vector;Viral;Virulence;Yeasts;γδ T cells

PROJECT_TITLE: Bio-engineered Cell Therapy to Treat Candidiasis

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Methamphetamine;Microbiome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE There is an existing gap of knowledge about the mechanisms that drive the development of depression in HIV infection and/or methamphetamine (METH) use. The central hypothesis of this proposal is that HIV and/or METH-induced inflammasome activation primes for depression. Our translation objective is to demonstrate that HIV infection and/or METH exposure contribute to, and accelerate the pathomechanisms of depression via the alterations of the gut-brain axis, which involves inflammasome activation and chronic brain neuroinflammatory responses.

PI_NAMEs: BEUREL, ELEONORE ;TOBOREK, MICHAL  (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Acceleration;Actinobacteria class;Affect;antiretroviral therapy;Bacteria;Blood - brain barrier anatomy;blood-brain barrier disruption;Brain;Cells;Chronic;Clinical Research;comorbidity;COVID-19 pandemic;Data Set;depressive symptoms;Desire for food;Development;Disease;drug misuse;economic implication;Enterobacteriaceae;Epidemiology;Event;Exhibits;experience;Functional disorder;Goals;gut bacteria;gut dysbiosis;gut microbiome;gut microbiota;gut-brain axis;Health;HIV;HIV Infections;humanized mouse;Individual;Infection;Inflammasome;innovation;Intervention;Knowledge;Life Expectancy;Major Depressive Disorder;Medical;men;Mental Depression;Mental disorders;Methamphetamine;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;Moods;mouse model;Mus;neuroinflammation;neuropsychiatry;Neurotransmitters;novel;Pathway interactions;Patients;Persons;pharmacologic;pleasure;Precision therapeutics;Predisposition;Prevalence;prevent;Process;Public Health;Publishing;response;Role;Sleep;social implication;Substance Use Disorder;suicidal risk;Therapeutic;Therapeutic Intervention;Tissues;Translations;United States;Up-Regulation;Woman

PROJECT_TITLE: Inflammasome Activation and Gut-Brain Axis Dysregulation in HIV and Methamphetamine-Associated Depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 JRB-N (O1)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Congenital Structural Anomalies;Genetics;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Relevance  Many birth defects and a wide spectrum of highly prevalent cancers arise from aberrant regulation of the Hedgehog (Hh) signaling pathway. Most components of this pathway were first discovered in Drosophila and then found to have equivalent roles in mammals, leading to improved diagnoses of human disease and the development of promising anti-cancer drugs. Further progress in addressing these health issues will be spurred by a deeper understanding of the mechanism of Hh signaling, gained from the continued genetic analysis in Drosophila outlined in this project, focused on the key question of how the transcriptional effector of Hh signaling is activated.

PI_NAMEs: KALDERON, DANIEL D (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Address;adult stem cell;Affect;Alleles;Antineoplastic Agents;Binding;Binding Sites;Biochemical;Biological Assay;cancer type;cell behavior;Childhood Medulloblastomas;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combat;Complex;Congenital Abnormality;Cyclic AMP-Dependent Protein Kinases;Dedications;Development;developmental disease;Diagnosis;Diagnostic;Disease;Dissociation;Drosophila genus;Drosophila inturned protein;drug development;Drug Targeting;Embryonic Development;Erinaceidae;extracellular;Family;fly;Functional disorder;Genetic;genetic analysis;genetic approach;genetic testing;Genetic Transcription;Genotype;Germ Cells;GLI gene;GLI2 gene;Health;hedgehog signal transduction;Holoprosencephaly;Human;human disease;Immunoprecipitation;improved;in vivo;inhibitor;insight;Integral Membrane Protein;Investigation;Investments;Knowledge;Length;Malignant Neoplasms;Mammals;Measures;Mediating;Medulloblastoma;member;Membrane Proteins;Molecular;Molecular Conformation;Molecular Genetics;Mutation;Organism;Pathway interactions;Pattern;Pharmaceutical Preparations;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;Post-Translational Protein Processing;Process;Protein Kinase;Proteins;Proteolytic Processing;receptor;Regulation;Resources;response;restraint;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Site;smoothened signaling pathway;Speed;stem cells;stoichiometry;Syndrome;Testing;Transcription Coactivator;transcription factor;Transcription Repressor;Variant

PROJECT_TITLE: Hedgehog signal transduction: mechanism of Ci/Gli transcriptional effector activation

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]