ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Depression;Estrogen;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative Women participating in shift work are more likely to develop premenstrual disorders, indicating an overlooked opportunity to understand how light-induced disruption of biological rhythms, sex hormones, and mood impact women’s reproductive health. This project aims to uncover the connection between mood and menstrual cycle abnormalities using both shiftwork-like lighting conditions and site-specific viral approaches. This new knowledge is a first step towards future studies to understand and mitigate the harmful effects of shift work on women’s reproductive health.

PI_NAMEs: VAN LOH, BROOKE MARIE (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Anhedonia;antisocial behavior;Anxiety;Behavior assessment;behavior test;Behavioral;Biological Assay;Biological Rhythm;Brain;Chronic;Clinical;Corticosterone;Darkness;Data;Depressive disorder;depressive symptoms;Diagnosis;Disease;effective therapy;Estrous Cycle;Estrus;experience;Exposure to;Eye;Faculty;Female;Future;Genetic;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Health;Histologic;Hormones;Human;human female;Hypothalamic structure;improved;Injections;insight;Intraperitoneal Injections;Knowledge;Lead;Light;Lighting;Low Income Population;Luteal Phase;Manuscripts;Measures;Menstrual cycle;Menstruation Disturbances;Mental Depression;Mental Health;Moods;Morphology;mouse model;Mus;Neurons;Neurosecretory Systems;novel;Ovarian;Ovarian Follicle;Ovulation;Pain;Periodicity;Physiological Processes;Population;preference;premenstrual dysphoric disorder;reproductive;Reproductive Health;reproductive hormone;response;Retina;Rewards;Risk;Rodent Model;Role;Rotation;Schedule;shift work;Site;social;Stress;Sucrose;suprachiasmatic nucleus;Symptoms;Testing;Tetanus Toxin;Time;tool;Training;Transgenic Mice;Transgenic Organisms;Vasoactive Intestinal Peptide;vesicular release;Viral;Woman;women's reproductive health;women's treatment;Work

PROJECT_TITLE: The impacts of shift work-like lighting on neuroendocrine function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Arousal is a ubiquitous influence on the brain that continuously fluctuates during wakefulness and enables sensation and perception. This project aims to elucidate the arousal-dependent effects on subpopulations of excitatory cortical neurons in terms of their response properties and subsequent impact on behavior. Results from these experiments could advance our understanding of the neural correlates of optimal performance and motivate novel theories on decision-making, sensory encoding, and the function of specific cortical cell-types.

PI_NAMEs: KAUFMAN, KEITH  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Active Listening;Anatomy;Animals;Arousal;Auditory;Auditory area;auditory categorization;auditory pathway;auditory processing;Auditory system;awake;Behavior;Behavior assessment;behavior influence;Behavioral;Biological Markers;Brain;Calcium;calcium indicator;Categories;cell cortex;cell type;Cells;Code;Color;Communication;Data;Decision Making;Detection;Diameter;Disparate;Electrophysiology (science);Esthesia;experimental study;forging;Frequencies;Head;Hyperactivity;Image;In Vitro;in vivo;in vivo calcium imaging;information processing;Investigation;Knowledge;Label;Laws;Link;Measures;Monitor;Morphology;Motor;Mus;Nervous System;neural;neural correlate;Neurons;neuroregulation;novel;Output;Pathway interactions;Pattern;Perception;Performance;Physiology;Play;Positioning Attribute;Property;Psychometrics;Pupil;Recording of previous events;recruit;Reporting;Research;Research Proposals;response;Role;Sensory;Shapes;Signal Transduction;Site;sound;System;Task Performances;Telencephalon;Testing;theories;two-photon;Viral;Wakefulness

PROJECT_TITLE: Arousal-dependent modulation of layer 5 neurons in the auditory cortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: DENTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS

ORG_STATE: TX

PHR: Project Narrative  Slo2 channels play important physiological roles in the human brain. The proposed work is to use the nematode C. elegans as a model system to investigate how several novel Slo2 channel regulators perform their physiological functions, with the long-term goal being to better understand Slo2 channel physiological functions and diseases caused by Slo2 channel mutations.

PI_NAMEs: CHEN, BOJUN  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biological Models;Brain;Caenorhabditis elegans;CCL13 gene;Disease;DNA-Binding Proteins;Epilepsy;Family;forward genetics;genetic approach;genetic regulatory protein;Genetic Transcription;Goals;Homologous Gene;Human;Intellectual functioning disability;Invertebrates;Knowledge;Mammals;Molecular;Mus;Mutation;Names;Nematoda;Nervous System;Neurons;novel;Physiological;Play;Potassium Channel;Property;Protein Tyrosine Phosphatase;Proteins;Regulation;Research;RNA;RNA Editing;Role;SAFB gene;Shapes;Work

PROJECT_TITLE: Novel regulators of Slo2 potassium channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Malaria;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Seasonal malaria chemoprevention and RTS,S vaccination are new interventions available to prevent malaria in children under five years of age in malaria-endemic countries. We need to understand their impact on the risk of malaria as the children get older because school-age children already have a high burden of malaria infection. We propose a longitudinal cohort study of four groups of children with exposures to different combinations of interventions to evaluate their impact on the risk of malaria as the children get older and examine the sustained effect on the human immune responses and the parasite.

PI_NAMEs: ASANTE, KWAKU POKU;LAUFER, MIRIAM K. (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 5 year old;7 year old;Address;Africa South of the Sahara;Age;aged;Alleles;Anti-malarials;Antibody Response;Area;burden of illness;Chemoprevention;Child;Clinical;clinical implementation;comparison intervention;Country;design;Development;Disease;Drug resistance;early childhood;Epidemiology;Epitope Mapping;Erythrocytes;experience;Exposure to;Falciparum Malaria;Genomic approach;Genomics;Geographic Locations;Ghana;Health;High Prevalence;Human;human old age (65+);Immune;Immune response;Immunity;Immunization;Immunologics;implementation study;Incidence;Infection;infection risk;innovation;Intervention;Knowledge;Lead;Life;Longitudinal cohort study;Longitudinal Studies;Malaria;malaria infection;Malaria prevention;Malaria Vaccines;Maryland;Monoclonal Antibodies;Morbidity - disease rate;mortality;next generation;Outcome;Parasites;Parasitology;Pattern;Pharmaceutical Preparations;Pilot Projects;Plasmodium falciparum;Policies;Policy Maker;Population;Predisposition;pressure;Prevalence;prevent;Preventive treatment;programs;Proteins;Randomized;Recommendation;Recording of previous events;Research;resistance mutation;response;Risk;School-Age Population;Schools;Seasons;Series;Serology;Severity of illness;System;Time;transmission process;Universities;unvaccinated;Vaccinated;Vaccination;Vaccine Clinical Trial;vaccine-induced antibodies;Vaccines;World Health Organization

PROJECT_TITLE: Impact of early childhood malaria prevention on malaria risk at school entry (ERASE)

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Myeloid malignancies are prevalent and result in significant morbidity and mortality, yet patient outcomes may differ substantially even when the same driver gene is mutated. Exploring the dysregulation of alternative polyadenylation, a post-transcriptional regulatory mechanism, in AML will enhance our comprehension of disease heterogeneity and contribute to our understanding of molecular drivers of hematologic malignancies.

PI_NAMEs: KOWALSKI, MADELINE HEIDI (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 3' Untranslated Regions;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;Automobile Driving;Base Sequence;cancer cell;cancer stem cell;Cell Line;cell type;Cells;cleavage factor;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Comprehension;computational platform;Computing Methodologies;CRISPR-mediated transcriptional activation;Data;Data Set;deep learning;deep learning model;disease heterogeneity;Disease Progression;Down-Regulation;Exhibits;Fibrinogen;Genes;Genetic Transcription;Genotype;Hematologic Neoplasms;Hematopoietic;Hematopoietic stem cells;Heterogeneity;Human;improved;Individual;Learning;leukemia;Leukemic Cell;Leukemic Hematopoietic Stem Cell;leukemic stem cell;Maintenance;Malignant - descriptor;Malignant Neoplasms;malignant state;Messenger RNA;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Cleavage and Polyadenylation Factors;Mutate;Mutation;mutational status;Myelogenous;Myeloproliferative disease;new therapeutic target;non-genetic;Normal Cell;Outcome;overexpression;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Performance;Polyadenylation;Population;posttranscriptional;predictive modeling;Process;progenitor;Publishing;Resolution;Sampling;Signal Transduction;single-cell RNA sequencing;Site;stem;stem cell differentiation;stem cell population;Testing;tool;Training;Transcript;transcriptome;treatment response

PROJECT_TITLE: Decoding the Molecular Basis of Dysregulated Cleavage and Polyadenylation in Myeloid Malignancies - Resubmission - 1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Narrative Transfer (t)RNAs are a class of small regulatory RNAs required for protein synthesis. Aberrant tRNA processing, modification, and expression has been associated with rare and common genetically complex neurological diseases, however, tools to measure tRNAs at the single cell level are lacking. We propose to develop a novel single nuclei tRNA sequencing method to profile tRNAs in human stem cell based organoid development and disease to reveal new pathophysiological mechanisms.

PI_NAMEs: SCHAFFER, ASHLEIGH E (contact);SWEET, THOMAS J

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Biogenesis;Bioinformatics;Biological Assay;Biological Models;Brain;Cancer Biology;Cell Culture Techniques;Cell Nucleus;Cell Separation;cell type;Cells;Central Nervous System;Cerebrum;clinically relevant;Complementary DNA;Complex;Custom;Data;Defect;Development;differential expression;Disease;disease model;disease-causing mutation;Fluorescent in Situ Hybridization;Foundations;Freezing;Fresh Tissue;Genetic Transcription;Genomics;Goals;Health;Homeostasis;Human;human embryonic stem cell;Human Genetics;human stem cells;In Situ;Individual;information processing;innovation;insight;Laboratories;Length;leukodystrophy;Malignant Neoplasms;Maps;Measures;Methods;MicroRNAs;Modeling;Modification;Motor Neurons;mutant;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Neurobiology;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neurons;next generation sequencing;Normal tissue morphology;novel;Nucleotides;Organoids;Pathogenicity;Patients;Pattern;Performance;Phenotype;Phosphotransferases;Polyadenylation;Population;premature;Protein Biosynthesis;Protocols documentation;Regulation;Reproducibility;Research;Resolution;RNA;RNA Processing;single nucleus RNA-sequencing;Small RNA;Source;stem cells;System;Techniques;Technology;therapeutic development;Time;tissue culture;Tissues;tool;transcriptome sequencing;Transfer RNA;Untranslated RNA;Up-Regulation;Variant;virology;Virus Diseases;Work

PROJECT_TITLE: Developing single nuclei tRNA-seq to profile tRNA diversity at the single cell level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-G (06)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW ORLEANS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Preeclampsia (PE) is a pregnancy-specific disorder that is characterized by hypertension and proteinuria (maternal syndrome) developing after the 20th week of gestation, and PE is the leading cause of maternal morbidity and mortality in the United States, affecting about 5-7% of pregnancies. Given the great health and economic burden of PE, there is tremendous importance for better understanding the mechanisms involved in the progression of preeclampsia especially since mother and child are impacted by this disease. The studies in this proposal will help understand the progression of the disease by testing the hypothesis that maternal syndrome in Dahl SS rats is an outcome of improper placentation resulting in an increased oxidative stress due to infiltration of T cells into kidneys and placental tissue causing subsequent endothelial dysfunction that contributes to the development of hypertension and renal damage.

PI_NAMEs: DASINGER, JOHN H (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Address;adverse pregnancy outcome;Advisory Committees;Affect;Animal Model;Aptitude;Arteries;Blood Urea Nitrogen;Cerebrum;Child;Chronic Kidney Failure;Clinical;Creatinine clearance measurement;Dahl Hypertensive Rats;Data;Death Rate;Development;Diet;Disease;disease phenotype;Disease Progression;Economic Burden;endothelial dysfunction;Endothelium;Ensure;Excretory function;Exhibits;fetal;Future;Genes;Genetic;Goals;Grant;Health;hemodynamics;Hepatic;Histologic;Human;Hypertension;Hypertrophy;Impaired Renal Function;Impairment;improved;indexing;Intervention;Kidney;Kidney Diseases;kidney dysfunction;Kidney Failure;Knowledge;late life;maternal morbidity;Maternal Mortality;maternal outcome;Measurement;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Mothers;neutrophil cytosol factor 67K;normotensive;novel;Operative Surgical Procedures;Outcome;Oxidative Stress;Pathogenesis;pharmacologic;Phase;Phenotype;Placenta;Placentation;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;Principal Investigator;Process;Proteins;Proteinuria;Rattus;Reactive Oxygen Species;renal damage;Resistance;restoration;Risk;Sodium Chloride;Spiral Artery of the Endometrium;Splenocyte;Syndrome;T cell infiltration;T-Lymphocyte;Testing;Tissues;United States;Uterus;Woman

PROJECT_TITLE: Nox2-derived oxidative stress produced by T cells contributes to the development of maternal syndrome in the Dahl salt-sensitive rat.

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Over 10 million women in the United States have reported experiencing reproductive coercion, a form of intimate partner violence involving deliberate actions to undermine a person’s reproductive choices, such as sabotaging contraception, thereby increasing women’s risk for sexually transmitted infections, including HIV. The proposed mixed methods study will explore social determinants of health influencing reproductive coercion prevalence, focusing on neighborhood socioeconomic status, healthcare access, and state contraception policy. Findings are anticipated to inform the development of an intervention to address the health information and support needs of affected women to prevent further violence and the acquisition of sexually transmitted infections.

PI_NAMEs: HAHN, ALEXANDRIA LOUISE (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: 14 year old;Address;Affect;aged;AIDS prevention;American;Area;Behavior;Behavioral;Biological Markers;black women;care seeking;career;Censuses;Chlamydia;Communities;Community Surveys;community-level factor;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Data;Data Set;Dedications;design;Development;Disparity;Economics;Education;epidemiologic data;Epidemiology;epidemiology study;Equity;ethnic minority;Ethnic Population;experience;Exposure to;Future;Glass;Goals;Gonorrhea;Health;health care availability;health equity;Health equity research;Health Resources;Health Services;Health Status;Healthcare;High Risk Woman;HIV;Incidence;Individual;Inequality;Inequity;insight;Interview;intimate partner violence;investigator training;Knowledge;Latina;low socioeconomic status;Measures;Methods;Mission;multi-racial;multilevel analysis;Neighborhoods;Nurses;Patient Self-Report;Persons;Policies;Pregnancy;Prevalence;prevent;Principal Investigator;programs;protective factors;racial minority;racial population;recruit;Reporting;reproductive;reproductive coercion;Reproductive Health;Research;Risk;Risk Factors;Role;Safe Sex;Sampling;Scientist;Sex Behavior;sexual and reproductive health;Sexually Transmitted Diseases;skills;social;social determinants;social health determinants;social influence;Social Network;sociodemographics;Socioeconomic Status;Statistical Data Interpretation;Structure;Surveys;Syphilis;Testing;therapy development;Training;Training Activity;training opportunity;Training Support;Trichomonas;unintended pregnancy;United States;Violence;White Women;Woman;Women's Health;women's reproductive health;young woman

PROJECT_TITLE: The Role of Social Determinants in Reproductive Coercion: Understanding Health Information and Support Needs

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]


NIH_SPENDING_CATS: Lung;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Humans and other mammals use strong nasal inhalations, or sniffs, to smell the world, providing them with information about nearby foods, animals, and the local environment. This project aims to understand how the parabrachial nucleus, a part of the brain implicated in respiratory control, may contribute to the generation of sniffing behaviors in mice. This work will ultimately contribute to our understanding of smell and active sensing in humans.

PI_NAMEs: PEARL, JONAH ELI (contact)

PROJECT_TERMS: active control;Acute;Affect;Amygdaloid structure;Anatomy;Animals;antagonist;awake;Behavior;Behavioral;Brain;Breathing;Calcitonin Gene-Related Peptide;Carbon Dioxide;Cell Nucleus;Cell Shape;cell type;Cells;Dopamine;Endowment;Environment;Etiology;Exhibits;experimental study;Fire - disasters;Food;free behavior;Generations;Glutamates;Head;Head Movements;Human;Hypercapnia;In Vitro;Inhalation;insight;laboratory experience;Liquid substance;Location;Maintenance;Mammals;Mediating;midbrain central gray substance;Modeling;Monitor;Motor;Mus;neural;neural circuit;Neuromodulator;Neurons;Neuropeptides;neuroregulation;Nociception;Nose;novel;Odors;Olfactory Epithelium;olfactory receptor;Opioid;optogenetics;Output;Pain;parabrachial nucleus;Pattern;Periodicity;Peripheral;Play;Pontine structure;Population;Resources;Respiration;respiratory;Respiratory Diaphragm;response;Role;Sampling;segregation;Shapes;Signal Transduction;Smell Perception;Source;spatiotemporal;Speed;Stimulus;Structure;superior colliculus Corpora quadrigemina;Synapses;Synaptic Transmission;Tachykinin;Tachykinin Receptor;Testing;Time;transmission process;Trigeminal Nuclei;Work

PROJECT_TITLE: Sniff-controlling Circuitry in the Parabrachial Nucleus

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (59)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Diabetes;Dissemination and Implementation Research;Health Services;Kidney Disease;Prevention;Primary Health Care

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative The concomitant presence of chronic kidney disease (CKD) substantially increases the risk of cardiovascular disease (CVD) for persons with type 2 diabetes mellitus (T2DM). Yet, widely available therapies that can vastly lower this risk remain markedly under-prescribed. In response, this proposal seeks to design, implement and evaluate an educational intervention to increase prescription of cardio-renal preventive therapies among patients with T2DM and CKD.

PI_NAMEs: LAMPREA MONTEALEGRE, JULIO ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Accounting;Adoption;Affect;Agonist;Algorithms;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Award;Awareness;burden of illness;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;career;Caring;case-based;Chronic Kidney Failure;Clinic;Clinical;Complex;Data Set;demographics;design;Detection;Development;Dialysis procedure;Disease Progression;Drug Prescriptions;Education;Educational Intervention;Educational Materials;effective intervention;Endocrinologist;Endocrinology;Environment;evidence base;experience;Facility Controls;Focus Groups;Geography;GLP-I receptor;Glucose;Health system;Healthcare Systems;high risk;implementation science;implementation strategy;improved;improved outcome;Individual;inhibitor;Interdisciplinary Education;Intervention;Knowledge;Lead;Life;Medical;medical specialties;Medicine;Mentors;Methods;Nephrology;Non-Insulin-Dependent Diabetes Mellitus;novel;Pamphlets;Patient Care;patient oriented;Patients;Persons;Phase;Positioning Attribute;posters;Preventive;Preventive care;Preventive therapy;Preventive treatment;Primary Care;primary care provider;programs;progression risk;Provider;Quasi-experiment;Recommendation;Reporting;Research;Research Methodology;response;Risk;Self Efficacy;Services;Severity of illness;skills;Sodium;symporter;symposium;System;Training;trend;United States Department of Veterans Affairs;Veterans Health Administration

PROJECT_TITLE: Closing the Cardio-Renal Preventive Treatment Gap Among Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease: An Implementation Science Approach


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE More than seven million Americans are currently living with Alzheimer's disease (AD) and related tauopathies, and although significant progress has been made in delineating critical innate immune receptors involved in disease progression, much of the downstream signaling molecules modulating this immune response remain inadequately described. In our preliminary studies using a tau-based model of AD and frontotemporal dementia, we have identified an integral role for the immune signaling kinase, SYK. This project aims to further characterize the role of SYK in the exacerbation AD pathology through the regulation of microglia activation and to also evaluate if delayed SYK deletion is therapeutically efficacious in limiting tauopathy onset and progression.

PI_NAMEs: JOHNSON, ALEXIS MARIE (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Ablation;Affect;Age Months;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;American;Amyloid beta-Protein;Amyloidosis;Animals;Anti-Inflammatory Agents;Area;Autophagocytosis;Brain;Categories;CD22 gene;cell growth;Cells;Central Nervous System;clinically relevant;Cognition;cognitive ability;Cognitive deficits;cognitive function;Coupled;cytokine;Dementia;Disease;Disease associated microglia;disease model;Disease Outcome;Disease Progression;disorder control;Environment;Etiology;Excision;Exhibits;extracellular;Frontotemporal Dementia;Future;Gene Expression Profile;Genetic;genome wide association study;glial activation;Gliosis;Goals;Hippocampus;hyperphosphorylated tau;Immune;Immune response;Immune signaling;Immunologic Receptors;immunoregulation;Impaired cognition;improved;Infection;Inflammation;Inflammatory;innovation;insight;Intervention;Investigation;Link;Literature;Macrophage;Maintenance;Mediating;Mediator;Microglia;Molecular;mouse model;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuropathology;neuroprotection;neurotoxic;Onset of illness;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Pattern;Peripheral;Phagocytosis;Phosphotransferases;Pick Disease of the Brain;Play;Population;Prevalence;Production;protective pathway;receptor;Regulation;Reporting;Research;response;restraint;Role;Senile Plaques;Severities;Shapes;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Sorting;SYK gene;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;translational potential;Treatment Efficacy;TREM2 gene;Tyrosine;Weaning;Work

PROJECT_TITLE: Exploring the Role of Microglia SYK Signaling in Tauopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Generating hematopoietic stem cells (HSCs) in vitro represents a central aim in regenerative biology due to their significant therapeutic potential for the treatment of blood diseases, including leukemia and lymphomas. In vitro derivation of HSCs for use in the clinic still remains challenging, in part due to incomplete understanding of the steps leading to blood development in vivo. This proposal aims to use next-generation molecular recording technologies to shed light on the biology of developmental hematopoiesis, focusing on the origin, molecular drivers and extrinsic triggers of the process, with the overarching aim of informing and improving strategies for HSC derivation in vitro.

PI_NAMEs: BOWLING, SARAH  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Anatomy;Aorta;Area;Automobile Driving;Bar Codes;Behavior;Blood;Blood Cells;Blood flow;blood formation;blood treatment;Bone Marrow Purging;Boston;career development;Catalogs;cell behavior;Cell Lineage;Cells;chemotherapy;Clinic;Clinical;clinically relevant;Computer Analysis;CRISPR/Cas technology;Cues;Data;Data Set;Derivation procedure;Development;Developmental Biology;DNA;driving force;Embryo;Endothelial Cells;endothelial stem cell;Endothelium;Engraftment;Environment;Epigenetic Process;experimental study;Fetal Liver;Generations;Genes;Genetic Transcription;Goals;Growth;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell emergence;hematopoietic stem cell formation;Hematopoietic stem cells;hemogenic endothelium;Heterogeneity;human pluripotent stem cell;improved;In Vitro;in vivo;induced pluripotent stem cell;innovation;Investigation;Knowledge;leukemia/lymphoma;Location;Maps;medical schools;Mentors;Mentorship;Molecular;Molecular Profiling;mouse model;multiple omics;Mus;Names;Natural regeneration;next generation;novel strategies;Organism;Outcome;Output;Pediatric Hospitals;Phase;Physiological;Pluripotent Stem Cells;post-doctoral training;Postdoctoral Fellow;Preparation;Process;Production;Productivity;programs;Property;Protocols documentation;Publishing;Records;regenerative biology;Research;Research Personnel;Resolution;Resources;Role;Route;Site;skills;stem cell function;stem cells;System;Techniques;Technology;technology development;Testing;Therapeutic;Time;tool;Training;Work

PROJECT_TITLE: Cellular barcoding of developmental hematopoiesis


NIH_SPENDING_CATS: Cancer;Genetics;Prevention;Skin Cancer

PHR: PROJECT NARRATIVE Advancing methods of prevention and early detection for melanoma, the deadliest skin cancer, is critical. This proposal seeks to uncover extracellular pathways driving melanoma initiation. A better understanding of the mechanisms involved in melanoma initiation will allow for the development of therapeutics that stop melanoma from forming in the first place.

PI_NAMEs: HONGO, RACHEL  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Adult;Affect;Area;Automobile Driving;cancer transplantation;candidate identification;cell type;Cells;Chemicals;Complex;Cyclic AMP;Early Diagnosis;Embryo;Excision;experimental study;extracellular;Fertilization;Flow Cytometry;fluorescence imaging;Genes;genetic approach;Genetic Transcription;Growth;Growth Factor;Histologic;Human;human model;Image;in vivo;in vivo fluorescence imaging;interest;Ligands;Malignant Neoplasms;MAP Kinase Gene;matrigel;melanocyte;Melanoma;Methods;microphthalmia-associated transcription factor;Modeling;mutant;Mutation;Neural Crest;Oncogenic;Operative Surgical Procedures;Orthologous Gene;Pathway interactions;prevent;Prevention;Process;progenitor;promoter;Proteins;Proteomics;Proto-Oncogene Protein c-kit;Regulation;Reporter;RNA;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Skin Cancer;Source;Stem Cell Factor;Study models;Temperature;Testing;therapeutic development;Therapeutically Targetable;Time;TP53 gene;transcription factor;transcriptome sequencing;Transgenic Organisms;Transplantation;tumor;Tumor Suppressor Proteins;Zebrafish

PROJECT_TITLE: Investigating microphthalmia-associated transcription factor (MITF) and growth factors as initiators of melanoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-C (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: 8. PROJECT NARRATIVE The study aims to evaluate the direct and indirect impact of a status-neutral person-centric structural intervention in New Delhi on HIV outcomes (HIV incidence and HIV viral suppression) among people who inject drugs in New Delhi and spillover effects on other populations in New Delhi and PWID across India.

PI_NAMEs: CLIPMAN, STEVEN J.;SOLOMON, SUNIL SUHAS (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Abscess;Address;AIDS prevention;Automobile Driving;Behavioral;Biometry;Caring;Cities;Clinic;cohort;Communities;Complex;condoms;Counseling;Cross-Sectional Studies;Data;Data Analyses;data integration;Diffusion;Disease;Drug usage;Epidemic;Evaluation;experience;Face;follow-up;Food;Foundations;Genes;genome sequencing;Geography;Government;Harm Reduction;Hepatitis B Virus;Hepatitis C Transmission;Hepatitis C virus;Heterosexuals;HIV;HIV Infections;Home;Homelessness;Incidence;India;Industry;Injecting drug user;Injections;Intervention;Link;Location;Medical;medication for opioid use disorder;men who have sex with men;Mental Health;Methods;migration;Modeling;mortality;Nature;network models;Network-based;novel;novel strategies;nutrition;Outcome;Participant;Persons;Phylogenetic Analysis;Policies;Population;pre-exposure prophylaxis;Prevalence;Public Sector;public-private partnership;Rapid diagnostics;Recording of previous events;recruit;Reporting;Risk;Same-sex;Sampling;Sequence Analysis;serosurvey;Services;sex;Sexual Partners;Sexually Transmitted Diseases;Site;social structure;Social Work;Source;Specimen;Syringes;Time;transmission process;treatment site;Viral;Visit;Vulnerable Populations;whole genome;Work

PROJECT_TITLE: Estimating the direct and indirect effects of a status-neutral person-centric intervention on HIV transmission among PWID in India


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project is relevant to public health because healthcare discrimination is common, inequitably experienced, and associated with worse health outcomes. One way discrimination and stigma manifest in the healthcare system is through electronic health record (EHR) documentation; the prevalence and impact of EHR stigmatizing language in cancer care has not been investigated but may contribute to disparities in clinical decision-making and patient outcomes. Thus, this research aligns with the NIH’s mission to lead research in cancer survivorship, reduce health disparities, and help all people live longer, healthier lives.

PI_NAMEs: DONA, ALLISON C (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Address;Age;Ambulatory Care Facilities;American Society of Clinical Oncology;Biometry;cancer care;cancer health disparity;Cancer Pain Management;Cancer Survivorship;career;Caring;Categories;Characteristics;chronic pain;Clinic;Clinical;clinical application;clinical decision-making;Clinical Informatics;Clinical Oncology;clinical training;Community Healthcare;Community Practice;Data;Data Sources;Databases;demographics;Development;Discrimination;Disease;Disparity;disparity reduction;Doctor of Philosophy;doctoral student;Documentation;Drug Prescriptions;Electronic Health Record;Environment;Epidemiologist;Epidemiology;Epidermal Growth Factor Receptor;ethnic minority;experience;explicit bias;Fellowship;Future;Gender;Goals;Guidelines;Health;Health behavior;health disparity;Healthcare;Healthcare Systems;implicit bias;improved;improved outcome;Individual;Inequity;infancy;innovation;Intervention;Knowledge;Language;language outcome;Lead;Machine Learning;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;marginalization;Medical Records;medical schools;Mentors;Methods;Minnesota;Mission;Modeling;multidisciplinary;multilevel analysis;mutant;Natural Language Processing;Oncology;Opioid;Outcome;Outpatients;Pain;Pain management;patient health information;Patient-Focused Outcomes;Patients;Perception;Persons;phrases;Physicians;poor health outcome;prescription opioid;prescription pain reliever;Prevalence;programs;Provider;Public Health;Quality of Care;Race;racial minority;Random Allocation;Reader;Reading;Recording of previous events;Reduce health disparities;Reporting;Research;Research Design;rural dwellers;skills;social;Social Class;social culture;social stigma;Statistical Models;Stereotyping;Stigmatization;Substance Use Disorder;System;Testing;Text;theories;Training;United States National Institutes of Health;Universities;Visit;Work;Writing

PROJECT_TITLE: Stigmatizing Language in Cancer Care Electronic Health Records

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Urologic Diseases;Vaccine Related

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE: Chlamydia trachomatis (CT) causes roughly 128 million sexually transmitted infections globally each year. There are currently few interventions to protect people from infection with CT. This project will use data from research and disease surveillance to assess the feasibility of antibiotic treatment shortly after exposure to prevent CT infection and to estimate the population-level health impacts and cost-effectiveness of a hypothetical vaccine delivered before exposure to CT.

PI_NAMEs: ZANE, GREGORY  (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Accounting;Address;Adherence;Age;aged;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Bisexual;burden of illness;Calibration;Centers for Disease Control and Prevention (U.S.);Characteristics;Chlamydia Infections;Chlamydia trachomatis;cis-female;Communicable Diseases;comparison intervention;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;Data;Data Analyses;Diagnosis;Diagnostic tests;Disease Surveillance;Doxycycline;economic evaluation;Ectopic Pregnancy;efficacy evaluation;Eligibility Determination;Epididymitis;Evaluation;Event;Exposure to;Frequencies;Future;Gays;General Population;Genitalia;Genitourinary system;Gonorrhea;Health;health care availability;health economics;Health system;High Prevalence;HIV;immunogenic;improved;Incidence;incremental cost-effectiveness;Individual;Infection;infection burden;infection risk;Infertility;interdisciplinary approach;interest;Interruption;Intervention;Investigation;Knowledge;Laboratories;Literature;long-term sequelae;longitudinal analysis;major outer membrane protein;mathematical model;men who have sex with men;model development;Modeling;Neisseria gonorrhoeae;Outcome;Peer Review;Pelvic Inflammatory Disease;penis;Persons;Pharmaceutical Preparations;Phase;phase 3 study;phase I trial;Population;pre-exposure prophylaxis;prevent;Prevention;Prevention Measures;Prevention strategy;Preventive measure;Primary Prevention;Process;prophylactic;Prophylactic treatment;Prospective cohort;Prospective, cohort study;Prostitution;Public Health;Publishing Peer Reviews;randomized, controlled study;Rectum;Reporting;reproductive;Research;Research Personnel;Resistance;Risk;Safety;Sexually Transmitted Diseases;social stigma;Source;Structure;System;Testing;Testis;training opportunity;transgender women;Uncertainty;United States;Urethritis;Uterus;Vaccination;vaccination strategy;vaccine delivery;vaccine development;vaccine efficacy;vaccine evaluation;Vaccines;Work;World Health Organization;young woman

PROJECT_TITLE: Prevention of Chlamydia trachomatis infections: Evaluation of vaccination and post-exposure prophylactic antibiotic use as population-level strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Multidrug-resistant bacterial pathogens pose a serious public health problem that requires new solutions. I propose a strategy to combat Gram-positive pathogens through manipulation of the bacteria’s own chemical signaling system. This work will provide valuable insights into how bacteria produce the signals that trigger virulence along with new tools to fight pathogens.

PI_NAMEs: CLAY, ALYSSA PAIGE (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Address;Antibiotic Resistance;Bacteria;Behavior;Binding;Binding Sites;Biochemical;Biochemistry;Biological;Biological Assay;Cell Membrane Permeability;Cell Signaling Process;cell type;Cells;Cellular biology;chemical stability;Chemicals;chronic infection;combat;Cytolysis;design;Detection;Development;DNA Binding;Down-Regulation;Environment;experimental study;fighting;Functional disorder;functional group;Gene Expression;Genetic Transcription;Goals;Growth;Human;Immune Evasion;Immune response;Immune system;improved;In Vitro;Infection;Infiltration;inhibitor;insight;interest;Invaded;Knowledge;Lead;Ligand Binding;Macrophage;Mammalian Cell;Membrane;Microbial Biofilms;Microbiology;Molecular Target;Multi-Drug Resistance;National Research Service Awards;novel;Organic Chemistry;pathogen;pathogenic bacteria;Pathway interactions;Peptides;Permeability;Phenotype;Population Density;Positioning Attribute;Process;Property;protein-histidine kinase;Proteins;Public Health;quorum sensing;Regulator Genes;Reporter;Reporting;Resources;response;Role;Route;scaffold;screening;Series;Signal Transduction;skills;small molecule;small molecule inhibitor;Solubility;Staphylococcus aureus;Staphylococcus aureus infection;Structure;Structure-Activity Relationship;System;Techniques;Therapeutic;tool;Toxic effect;Toxin;Variant;Vesicle;Virulence;Work

PROJECT_TITLE: Design and application of small molecules for the interception of quorum sensing in Staphylococcus aureus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04A-V (20)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Genetic variants are typically transmitted from the parents to their offspring, but they can also arise after conception (post-zygotically acquired) during embryonic development. Genetic variants in SLC35A2 arising during brain development have recently been implicated in intractable focal epilepsy. In this study, we seek to: (1) determine the brain cell types involved in SLC35A2 epilepsy, (2) study effects of the variants on neuronal glycosylation, neuronal development, and neuronal activity, and (3) assess the ability of galactose supplementation to reverse the deleterious effects of the variants on neurons.

PI_NAMEs: CRINO, PETER B;HEINZEN, ERIN L (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: 3-Dimensional;Brain;brain cell;brain dysfunction;brain tissue;Cell Fraction;cell type;Cells;Conceptions;Cortical Dysplasia;Cortical Malformation;Data;de novo mutation;Defect;Development;Disease;druggable target;early onset;effectiveness evaluation;Electroporation;Embryonic Development;Epilepsy;epileptic encephalopathies;Galactose;Genes;genetic variant;Germ Lines;Germ-Line Mutation;Glutamates;glycosylation;Golgi Apparatus;hemimegalencephaly;Human;human induced pluripotent stem cells;in utero;Individual;Induced pluripotent stem cell derived human neuron;Intractable Epilepsy;Link;migration;mouse model;Mus;neocortical;nerve stem cell;neural;neural network;neurodevelopment;neurogenesis;neuron development;Neurons;novel;offspring;Organoids;Parents;Partial Epilepsies;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Polysaccharides;precision medicine;prevent;Process;Refractory;Resected;Role;Seizures;Severity of illness;Somatic Mutation;Specimen;Supplementation;Syndrome;Therapeutic;Translating;transmission process;Uridine Diphosphate Galactose;Variant;Work

PROJECT_TITLE: Defining disease mechanisms in SLC35A2 epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Repetitive transcranial magnetic stimulation (rTMS) is a promising neuromodulatory intervention for major depressive disorder (MDD), but the mechanism by which rTMS alters glutamatergic activity and functional connectivity to improve MDD symptoms is not fully understood. Here, we address methodological limitations in the extant literature by leveraging ultra-high field glutamate chemical exchange saturation transfer (GluCEST) imaging, resting-state functional magnetic resonance imaging (rsfMRI), and research-grade clinical phenotyping before and after a clinical rTMS intervention to elucidate clinically relevant glutamatergic and functional changes induced by rTMS. This proposal, rich with valuable training opportunities for the applicant, has the potential to generate unprecedented mechanistic insight that could lay the foundation for developing new and more personalized rTMS interventions for MDD.

PI_NAMEs: PECSOK, MARGARET KASEY (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adult;Anterior;antidepressant effect;anxious;Area;Atrophic;Attention;Award;Biological;Brain;Brain region;career;Chemicals;cingulate cortex;Clinical;Clinical assessments;clinical efficacy;clinical phenotype;clinical training;clinically relevant;Communication;connectome;cost;Data;Development;Diagnosis;Dimensions;disability;Doctor of Philosophy;DSM-V;Electromagnetics;emotion regulation;Emotional;Environment;FDA approved;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional plasticity;Future;glutamatergic signaling;Glutamates;Growth;Healthcare;Heterogeneity;Human;Image;imaging approach;imaging biomarker;imaging modality;Impairment;improved;improved outcome;in vivo;Individual;Individual Differences;innovation;insight;Intervention;Interview;Literature;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Major Depressive Disorder;Measures;Mediating;Mental Depression;Mentors;Methodology;Modeling;Mood Disorders;Motor;Multimodal Imaging;National Research Service Awards;neurochemistry;neuroimaging;neuroregulation;non-invasive imaging;novel;Outcome;outcome prediction;Patient Care;patient population;Patient-Focused Outcomes;Patients;Pharmacological Treatment;Phenotype;Physiologic pulse;Positioning Attribute;Psychiatrist;Psychiatry;psychologic;reduce symptoms;repetitive transcranial magnetic stimulation;Reporting;Reproducibility;Research;Research Design;Research Training;Resolution;Resources;response;Rest;Role;Science;Scientist;Severities;Site;skills;Societies;stem;Study Subject;symptomatic improvement;Symptoms;Synapses;Techniques;Training;training opportunity;treatment response;Unemployment;United States;Visit;Work

PROJECT_TITLE: Leveraging Ultra-High Field MRI to Elucidate Glutamatergic Mechanisms of rTMS in Depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This study aims to investigate how antigen-specific immunotherapy can selectively inhibit autoreactive T cells in autoimmune diabetes. Specifically, the research focuses on how induction of tolerance to a hybrid insulin peptide impacts the differentiation and function of autoreactive CD4 and CD8 T cells and how IL10+ regulatory T cells influence tolerance induction. The results of this study could provide important insights into the mechanisms underlying autoreactive T cell suppression following antigen-specific tolerance induction, potentially leading to the development of more effective immunotherapies for autoimmune diabetes.

PI_NAMEs: DILISIO, JAMES E (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: antibody immunotherapy;antigen-specific T cells;Antigens;ATAC-seq;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;autoreactive T cell;autoreactivity;Beta Cell;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cells;Cessation of life;Clinical Trials;Development;diabetic;Differentiation Antigens;effector T cell;experimental study;FDA approved;Flow Cytometry;Functional disorder;graft dysfunction;graft function;Graft Survival;Human;human disease;Hybrids;Hyperglycemia;Immunotherapy;Inbred NOD Mice;Individual;Infection;Infiltration;insight;Insulin;Insulin-Dependent Diabetes Mellitus;interest;Interleukin-10;islet;Islets of Langerhans;Islets of Langerhans Transplantation;Ligands;lymph nodes;Malignant Neoplasms;Mediating;Modeling;Monoclonal Antibodies;mouse model;Mus;nanoparticle;neoantigens;Onset of illness;Pathogenicity;Patients;Peptides;Phenotype;phenotypic biomarker;Post-Translational Protein Processing;preclinical study;Prediabetes syndrome;Productivity;Property;Regulatory T-Lymphocyte;Replacement Therapy;Research;restraint;Role;single-cell RNA sequencing;T cell infiltration;T-Cell Immunologic Specificity;T-Lymphocyte;Therapeutic;Tissues

PROJECT_TITLE: Induction of tolerance to a Hybrid Insulin Peptide and the impact on autoreactive T cell fate and function in autoimmune diabetic islet transplant

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Rehabilitation

PHR: PROJECT NARRATIVE The basal ganglia are thought to enable performance of complex, rapid action sequences. We will investigate neural activity in basal ganglia output in one of the most intricate discrete motor sequencing behaviors—speech production—using rare intracranial recordings from patients undergoing deep brain stimulation surgery.

PI_NAMEs: BULLOCK, PRICE LATANE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Area;Basal Ganglia;Basal Ganglia Diseases;Behavior;Boston;Brain;Brain region;brain surgery;career;Cell Nucleus;Clinical;Code;cognitive function;Complex;Computer Models;Data;Deep Brain Stimulation;design;Development;Dystonia;Electrodes;Exhibits;extracellular;Fire - disasters;Ganglia;General Hospitals;Globus Pallidus;Goals;Hearing;Human;Impairment;implantation;indexing;Influentials;Interdisciplinary Communication;Knowledge;Laboratory Research;Language;Learning;Life;Literature;Location;Mission;Modeling;Motor;motor behavior;motor disorder;motor learning;Movement;National Institute on Deafness and Other Communication Disorders;neural;Neurons;Neurosciences;nonhuman primate;Operating Rooms;Operative Surgical Procedures;Output;Parkinson Disease;Participant;Patient Care;Patients;Performance;Persons;phrases;Physiology;Population;Process;Production;Productivity;Quality of life;Recurrence;Research;Research Personnel;Resolution;Rodent;Role;Science;Signal Transduction;simulation;spatiotemporal;Speech;Speech Sound;Structure;Structure of subthalamic nucleus;Stuttering;System;Telephone;Testing;Thalamic structure;Time;Training;United States;Universities;Voice;Work

PROJECT_TITLE: Leveraging human intracranial recordings to quantitatively characterize basal ganglia output during speech

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (35)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative: Over 40 million people in the United States suffered from substance use disorder (SUD) in 2020. Exposure to chronic, unavoidable stress is a major contributor to drug misuse and high rates of recidivism for individuals with SUD. The goal of this fellowship is to further understand the harmful interaction between chronic stress and drug use in the context of altered neuroimmune communication to identify novel targets for attenuating stress effects in SUD.

PI_NAMEs: NOWAK, DAVID B (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Address;Affect;Architecture;Behavior;Behavioral;Brain;career;Cells;Chemotactic Factors;Choice Behavior;Chronic;Chronic stress;Clinical;Cocaine;Cocaine Dependence;cocaine exposure;Cocaine misuse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Collaborations;Communication;comorbidity;cost;Creativeness;Data;Dendritic Spines;density;Development;Dose;drug misuse;drug seeking behavior;Drug usage;effective therapy;Elements;environmental stressor;Exhibits;experience;experimental study;Exposure to;Extinction;FDA approved;Fellowship;Flow Cytometry;foot;Fostering;Functional disorder;Future;Glutamates;Goals;Growth;hippocampal pyramidal neuron;Immune;Individual;Infrastructure;Infusion procedures;insight;Intervention;Literature;Maintenance;Medial;Medical;Mental disorders;Mental Health;Mentorship;Metabolic;Microglia;Modeling;Molecular;Morphology;morphometry;Motivation;Neurobiology;Neuroimmune;neuroimmunology;Neurons;non-drug;novel;novel therapeutics;patient subsets;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;pharmacologic;Physicians;pre-clinical;preference;Prefrontal Cortex;Price;Process;Productivity;Psyche structure;Quantitative Reverse Transcriptase PCR;Rattus;recidivism;Recording of previous events;Recovery;recruit;Regulation;Reporting;Resources;response;Rewards;Rodent;Role;Scientist;sex;Shock;social;stimulant misuse;Stress;stressor;substance misuse;Substance Use Disorder;success;Sucrose;Talents;targeted treatment;Technical Expertise;Therapeutic Intervention;training opportunity;United States;Vertebral column;Violence

PROJECT_TITLE: Concurrent chronic stress and cocaine self-administration: Understanding effects on mPFC microglia and drug choice behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE In the United States, over 4 million births occur each year, and opioids are commonly prescribed to pregnant individuals for acute pain following surgery and childbirth. However, opioid prescribing is highly variable and often excessive, and few guidelines exist to direct postoperative pain management that are tailored to the needs of pregnant patients. In this prospective study, we will develop evidence-based, patient-centered guidelines to support postoperative pain management for pregnant and birthing individuals, create pragmatic strategies for guideline dissemination and implementation, and examine the effectiveness of guidelines and adaptive implementation strategies on the optimization of clinical and patient-reported outcomes for postoperative pain management.

PI_NAMEs: MONIZ, MICHELLE HELENA (contact);WALJEE, JENNIFER FILIP

PROGRAM_OFFICER_NAME: RASS, OLGA

PROJECT_TITLE: Clinical Practice Guidelines for Postoperative Pain in Pregnancy: Evidence, Dissemination, and Impact


NIH_SPENDING_CATS: Biotechnology;Disability Research;Eye Disease and Disorders of Vision;Hearing Loss;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Usher Syndrome

PHR: Project Narrative The sensory cells that respond to sound and gravitational stimuli have specialized structures on both their apical surface to detect mechanical stimuli and on their basal end to convert this stimulus to an electrical signal. This work aims to understand the functional maturation of human hair cells in stem-cell-derived human inner ear organoids. It also aims to study the dysfunction of these cells in a genetic disorder known to cause hearing and balance disorders and prevent their onset with viral-mediated gene therapy.

PI_NAMEs: NIST-LUND, CARL  (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Animal Model;Apical;Area;Basal lamina;Bathing;Benchmarking;Biological;Blindness;body position;Bypass;CDH23 gene;Cell Aggregation;Cell Line;Cell Physiology;cell type;Cells;Cilia;ciliopathy;Clinical Trials;Collection;Data;Deafblind;detector;Development;Disease;Disease Progression;early onset;Electron Microscopy;Electrophysiology (science);Endolymph;Environment;epithelial stem cell;Epithelium;equilibration disorder;Equilibrium;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;fetal;Functional disorder;Future;gene replacement;gene therapy;Generations;Genetic;Genetic Diseases;Hair Cells;hearing impairment;Hearing problem;Hereditary Disease;Histologic;Human;Human Development;human induced pluripotent stem cells;human tissue;Image;In Vitro;in vitro Model;in vivo;Individual;inner ear diseases;Inner Hair Cells;interest;Ion Channel;Labyrinth;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mesenchymal;Methods;Modeling;Molecular;Morphology;Movement;Mus;Mutation;Neurons;novel;novel strategies;novel therapeutics;Organoids;Otic Vesicle;Outcome;patch clamp;Pathogenicity;Pathology;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;PCDH15 gene;Phenotype;Physiological;Population;postnatal;preservation;presynaptic;prevent;Procedures;Process;progenitor;Property;protein expression;Proteins;Recovery of Function;response;ribbon synapse;Role;Sampling;Sensory;Sensory Disorders;Severities;Signal Transduction;single-cell RNA sequencing;sound;Stains;stem cell organoids;stem cells;Stimulus;Structure;Study models;Surface;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapy development;Thin Filament;Time;Tissues;transcriptomics;Translating;Usher Syndrome;Utricle structure;Vesicle;Vestibular dysfunction;Viral;Virus;Work

PROJECT_TITLE: Novel inner ear organoid models for studying hair cells in normal development and in the deaf-blindness disease Usher Syndrome Type 1F

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (13)]


ADMINISTERING_IC: HD

ED_INST_TYPE: PRIMATE CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: NARRATIVE The use of antiretroviral therapy (ART) for pregnant women prevents mother-to-child HIV transmission. However, the HIV-exposed, but uninfected children experience higher mortality from infections. We will use rhesus monkeys to determine how SIV/ART impacts the fetal immune system.

PI_NAMEs: VARLAMOV, OLEG  (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;adverse outcome;Age;Agonist;antiretroviral therapy;Architecture;arm;Biological Assay;Birth;bone;Bone Marrow;Breast Feeding;Breeding;CD34 gene;Cells;Cesarean section;Child;Circulation;Clinical;Clinical Research;clinical translation;clinically relevant;combinatorial;Control Groups;Defect;Development;Engraftment;exhaustion;Exhibits;experience;experimental group;Exposure to;Female;fetal;Fetal Development;Fetal Growth;Fetal Liver;Fetal Lung;Fetal Reduction;Fetal Tissues;Fetus;Flow Cytometry;Genetic Transcription;Goals;healthy pregnancy;Hematopoiesis;Hematopoietic stem cells;HIV;Homing;Human;Immune;immune activation;Immune system;immune system function;Immune Tolerance;Immunity;Immunohistochemistry;Impairment;improved;in utero;Infant;Infection;Inflammation;Intervention;Intravaginal Administration;Knowledge;Lymphocyte;Lymphocyte Function;Lymphoid Cell;Macaca mulatta;Macrophage;Maternal-Fetal Exchange;Measures;Mitochondria;Modeling;Molecular;monocyte;mortality;Mother-to-child HIV transmission;Mus;Myeloid Cell Activation;Myeloid Cells;Nutritional status;offspring;Outcome;Partner in relationship;pathogen;Pathogenesis;Pathway interactions;Phenotype;Play;Predisposition;pregnant;Pregnant Women;premature;prevent;Primates;Property;reconstitution;Regimen;reproductive;Resolution;Respiratory Disease;Respiratory Tract Infections;response;Role;Site;SIV;Socioeconomic Factors;stem cell differentiation;Stimulus;Stromal Cells;Systems Development;T-Lymphocyte;targeted treatment;Testing;Third Pregnancy Trimester;Tissues;Toxic effect;transcriptomics;Treatment Protocols;vaccine efficacy;Vertical Disease Transmission;Viral;Viral Pathogenesis;Viral reservoir;Viremia;Virus Diseases;Vulnerable Populations;Woman;Women's Group

PROJECT_TITLE: The impact of antiretroviral therapy on fetal immune system development in SIV-exposed rhesus macaques

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-A (57)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Dengue virus (DENV) causes millions of infections every year. The development of innovative disease control programs and forecasting methods requires an understanding of which DENV lineages cause outbreaks and of how these lineages spread and persist within communities. Through the proposed aims, we will determine how long it takes for DENV to cause an outbreak from the point of introduction and what environmental factors increase or decrease the time to outbreak.

PI_NAMEs: PORZUCEK, ABBEY  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affect;Africa;African;Americas;Arboviruses;Area;Asia;Cessation of life;chikungunya;climate change;Communities;COVID-19 pandemic;Culicidae;Data Set;Decision Making;Dengue;Dengue Hemorrhagic Fever;Dengue Virus;Development;Diagnostic;Disease Outbreaks;disorder control;Ebola;Economic Burden;Environmental Risk Factor;Epidemic;Epidemiology;Evolution;experience;Fever;Future;Genetic Variation;Genomics;Genotype;Geographic Factor;Geography;Goals;high risk;Incidence;Infection;innovation;insight;Knowledge;Linear Models;Measures;Methods;Modeling;Morbidity - disease rate;mortality;mosquito-borne;Mosquito-borne infectious disease;new outbreak;outbreak concern;Outcome;pathogen;Pattern;Phylogenetic Analysis;Phylogeny;Population Density;previous outbreak;Process;programs;Public Health;Reporting;Research;response;Serotyping;success;surveillance data;Symptoms;System;Time;time use;transmission process;trend;vaccination strategy;vaccine candidate;Variant;Viral Genome;viral genomics;viral transmission;Virus;Virus Diseases;virus genetics;whole genome;Wolbachia;Work;ZIKA

PROJECT_TITLE: Understanding the Impact of Dengue Virus Lineage Persistence on Outbreak Potential

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: This time-sensitive ancillary study to the TRUST trial will provide novel samples, matched samples of immune cells from blood and from synovial fluid of affected joints in active gout flare. Detailed studies will be performed of alterations in cell response and gene expression prior to and during gout flares and when simulated in an experimental cell culture environment. These mechanistic studies of gouty inflammation may lead to new therapies that target the molecular basis of gout flares.

PI_NAMEs: MERRIMAN, TONY R (contact);REYNOLDS, RICHARD JAMES

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: Affect;Agonist;Ancillary Study;arm;arthropathies;Blood;Blood Cells;Blood specimen;Candidate Disease Gene;Cartilage;Cell Culture System;Cell Culture Techniques;cell type;Cells;Clinical;Clinical Research;Clinical Trials;Collection;Consent;Data;Deposition;design;differential expression;Effector Cell;Enrollment;Environment;Fatty Acid Desaturases;Fatty Acids;Flare;Flow Cytometry;Frequencies;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;genome wide association study;Genomics;Gout;Hour;Immune;Individual;Inflammasome;Inflammation;Inflammatory;Inflammatory Arthritis;Innate Immune Response;innovation;insight;Interleukin-1 beta;Investigation;Joints;knock-down;Knowledge;Measurement;Measures;Mediating;Molecular;Molecular Genetics;molecular targeted therapies;monocyte;Mononuclear;Myelogenous;Myeloid Cells;Names;new therapeutic target;novel;Organ;Parents;Participant;Pathogenesis;Pathway interactions;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phagocytes;Phagocytosis;Phenotype;prevent;primary outcome;Production;Protocols documentation;Publishing;Randomized, Controlled Trials;Regulation;Research;Resources;response;Role;Sampling;Serum;Signal Transduction;single-cell RNA sequencing;Site;Source;Stimulant;Stimulus;Symptoms;Synovial Cell;Synovial Fluid;System;Testing;Time;Tissue-Specific Gene Expression;Tissues;TLR2 gene;TLR4 gene;Toll-like receptors;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Urate;Validation;Visit;Work

PROJECT_TITLE: Revealing novel mechanisms of gout flares by transcriptional phenotyping synovial and peripheral blood mononuclear cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 AJ (M1)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PHR: PROJECT NARRATIVE Alcohol use disorder is characterized by the inability of controlling or stopping alcohol use, even in the face of negative consequences or after long-term abstinence. Research shows that ventral tegmental area (VTA) dopaminergic neurons drive reward-seeking behavior and increased value of reward-associated cues while related studies show GABAB receptors and baclofen constraining behaviors like cue-induced reinstatement and compulsive alcohol use in the presence of an aversive stimulant. However, which receptors control the activity of VTA dopamine neurons on cue-related behaviors and which specific neuronal populations in the VTA are responsible for baclofen’s effects has yet to be determined, therefore, we are proposing test the role of GABAB receptors in VTA dopamine neurons on cue-induced reinstatement, aversion resistant drinking, and on the previously seen effects of baclofen.

PI_NAMEs: AGUIRRE, JONATHAN ISRAEL (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Ablation;Abstinence;addiction;Address;Agonist;alcohol behavior;Alcohol consumption;alcohol cue;alcohol relapse;alcohol seeking behavior;alcohol use disorder;Alcohols;Anterior;Baclofen;Behavior;behavior influence;Behavioral;Bilateral;Cannulas;Computer Analysis;Control Groups;CRISPR/Cas technology;cue reactivity;Cue-induced relapse;Cues;Data;Development;Dopamine;dopaminergic neuron;Dose;drinking;drinking behavior;driving behavior;Ethanol;experimental study;Extinction;GABA-B Receptor;gamma-Aminobutyric Acid;Genes;genetic manipulation;Goals;Guide RNA;habituation;Histologic;Imaging Techniques;Immunohistochemistry;Implant;Infusion procedures;Injections;insight;Intake;Learning;long term abstinence;Long-Evans Rats;Mentors;Methods;Microinjections;Modeling;Molecular Target;Motivation;Muscle relaxants;neuromechanism;Neurons;Neurosciences;Operative Surgical Procedures;Patients;Population;Probability;Procedures;Property;Quinine;Rattus;receptor;Receptor Activation;Relapse;Research;Research Personnel;Resistance;Rewards;Risk Factors;Rodent;Rodent Model;Role;Running;Self Administration;Site;skills;Source;Specific qualifier value;Stimulant;System;Testing;Training;Ventral Tegmental Area;Viral;Viral Vector;Visualization;Withdrawal Symptom;Work

PROJECT_TITLE: Effects of Ventral Tegmental Area Dopamine Neurons GABA-B Receptor Deletion on Cue-Evoked Relapse and Aversion-Resistant Drinking

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TUCSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Glymphatic activity (specifically the movement of neurofluid in extracellular and extravascular space that drains soluble neural metabolites from the nervous system) is essential for brain health, and development of interventional approaches to enhance glymphatic activity has great implication to care of neurological disorders including Alzheimer’s disease. We propose to 1) assess the feasibility of modulating glymphatic system through electromagnetic field-based slow wave entrainment in pigs anesthetized with propofol, and 2) measure the impact of slow wave entrainment on glymphatic activity using multi-contrast MRI.

PI_NAMEs: CHEN, NAN-KUEI  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Alzheimer's Disease;Amyloid beta-Protein;Anesthesia procedures;Animals;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier crossing;Brain;brain health;brain parenchyma;Cardiac;Caring;Cerebrospinal Fluid;cerebrospinal fluid clearance;cerebrospinal fluid flow;Circulation;contrast enhanced;Contrast Media;Data;design;Diffusion Magnetic Resonance Imaging;Electrocardiogram;Electroencephalography;Electromagnetic Fields;Excision;extracellular;Family suidae;ferumoxytol;Foundations;Frequencies;Future;glymphatic system;Goals;Human;human data;human subject;Image;improved;innovation;Intercellular Fluid;interest;Intervention;Intravenous;Isoflurane;Magnetic Resonance Imaging;Measurement;Measures;Movement;Nervous System;Nervous System Disorder;neural;neuroimaging;Neurons;neuropathology;neuroregulation;non rapid eye movement;Ommaya Reservoir;Parkinson Disease;pharmacologic;Phase;Physiologic pulse;Physiology;porcine model;Propofol;Role;Sampling;Signal Transduction;Sleep;Solid;Speed;Subarachnoid Space;tau Proteins;tau-1;therapy development;Time;Transcranial magnetic stimulation;Traumatic Brain Injury;Veins;Ventricular;wasting

PROJECT_TITLE: Investigating electromagnetic field-based neuromodulation of slow-wave brain activity and glymphatic system

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Cardiovascular;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE Abdominal aortic aneurysm (AAA) is characterized by progressive deterioration of the aortic wall and catastrophic aortic failure resulting in sudden death in >80% of acute ruptures leading to the death of at least 15,000 Americans every year. Unfortunately, there are no pharmacological treatments available for the prevention of AAA progression and the only option for these patients is surgical intervention. Our proposal seeks to evaluate platelets as the source of protective transforming growth factor β (TGFβ) and adventitial fibroblasts as the target cell type mediating this protection.

PI_NAMEs: SPUZZILLO, ANTHONY  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acute;Affect;Age;American;Aneurysm;Angiotensin II;Antibodies;Aorta;Aortic Aneurysm;Aortic Diseases;Attenuated;Binding;Blood Platelets;Caring;Cause of Death;Cell Proliferation;cell transformation;cell type;Cells;Cessation of life;Chest Pain;Chronic;Clinical;Communication;Complex;cytokine;Data;Death Rate;Deposition;Deterioration;Diagnosis;Diameter;Disease;Elastases;experience;Extracellular Matrix;Failure;Fibroblasts;follow-up;Goals;Growth;Homeostasis;imaging modality;In Vitro;in vivo;Incidence;Incidental Findings;Inflammation;Investigation;Lower Extremity;LoxP-flanked allele;Macrophage;Matrix Metalloproteinases;Mediating;Mediator;Medical;Medical Assistance;men;Mentorship;migration;Modeling;Molecular;monocyte;mortality;mouse Cre recombinase;mouse model;Mus;Myocardial Ischemia;novel therapeutics;Operative Surgical Procedures;overexpression;Pathogenesis;Pathologic;Pathology;Patients;Persons;PF4 Gene;pharmacologic;Pharmacological Treatment;Play;preclinical study;prevent;Prevention;Production;Proliferating;Protein Isoforms;Publications;Rattus;receptor;Recombinant Transforming Growth Factor;Recommendation;recruit;renal ischemia;repaired;Research;Research Personnel;Resistance;response;Rodent Model;Role;Rupture;Ruptured Aneurysm;Severities;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Source;Sudden Death;Testing;Therapeutic;therapeutic target;therapeutically effective;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;Transforming Growth Factors;Transgenic Mice;Translating;United States;Universities;Vascular Smooth Muscle;Woman;Work

PROJECT_TITLE: The Role of Platelet-Derived Transforming Growth Factor Beta in Abdominal Aortic Aneurysm

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-B (20)]


ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE This research proposal evaluates the impact of circulating estrogen on spinal cord inflammation and central nervous system plasticity. In support of NIH’s mission, this project will improve our understanding of the role of sex hormones and inflammation in facilitating neuroplasticity. These are critical considerations for optimizing neuroplasticity for neurorehabilitation clinical applications.

PI_NAMEs: DUNLAP-SMITH, AZALINE I (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;age related decline;Anti-Inflammatory Agents;Cells;Cervical spinal cord structure;Clinical;clinical application;Color;CSF1R gene;cytokine;Cytokine Gene;Data;design;Development;Environment;Estradiol;Estrogen decline;Estrogens;Estrous Cycle;Estrus;Excision;Fellowship;Female;Flow Cytometry;Foundations;Future;Gene Expression;Genes;Goals;Gonadal Steroid Hormones;Hypoxia;imaging Segmentation;Immune;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;Interleukin-1 beta;Interleukin-6;Intervention;Ketoprofen;Link;Lipopolysaccharides;male;Measures;Mediating;medical schools;Mentors;Microglia;mimetics;Minnesota;Mission;Modeling;Molecular Profiling;Morphology;Myelitis;Nervous System Disorder;neural;neurological recovery;neurological rehabilitation;Neuronal Plasticity;neurophysiology;neuroregulation;Non-Steroidal Anti-Inflammatory Agents;novel;Output;Ovariectomy;Ovary;permissiveness;Polymerase Chain Reaction;Population;Pre-Clinical Model;Production;programs;Proliferating;protein expression;Proteins;Quantitative Reverse Transcriptase PCR;Rattus;Regulation;rehabilitation science;Research;Research Activity;Research Personnel;Research Proposals;Research Training;respiratory;Respiratory Diaphragm;response;Reverse Transcription;Role;Science;sex cycle;sexual dimorphism;Signal Transduction;skills;Source;Spinal;Spinal Cord;Spinal cord injury;Stimulant;Stimulus;Stroke;Supplementation;System;systemic inflammatory response;Testing;Testis;Testosterone;Tissues;Training;United States National Institutes of Health;Universities;Viral;Wisconsin

PROJECT_TITLE: Estrogen modulation of spinal cord microglia for respiratory neuroplasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (08)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative: Cardiovascular disease accounts for 1 in 3 individuals in the US, often resulting from pressure-overload induced growth of the heart and consequent heart failure, a chronic condition for which we have no cure and a great unmet clinical need. The proposed work will study newly discovered aspects of vital cellular processes that are disrupted during pathological growth and contribute to progressive heart failure. Our studies will provide insight into whether targeting these disrupted cellular processes can serve as an effective therapeutic strategy to reduce mortality from heart disease.

PI_NAMEs: BAGCHI, SUKRITI  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Address;cancer cell;Cardiac;Cardiac Myocytes;Cardiac Output;Cardiovascular Diseases;Catalytic Domain;Cell Physiology;Chronic;Clinical;Development;Endoplasmic Reticulum;Equilibrium;experimental study;Face;functional decline;Functional disorder;Growth;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Human;Hypertension;Hypertrophy;Impairment;In Vitro;in vivo;Individual;innovation;insight;Intervention;knock-down;Left ventricular structure;Lysine;Mediating;Membrane;misfolded protein;Molecular;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Muscle Cells;mutant;N-terminal;Neonatal;Organelles;overexpression;Pathologic;Pathology;Phosphotransferases;Point Mutation;pressure;prevent;Process;Protein Biosynthesis;protein degradation;protein folding;Proteins;proteostasis;Rattus;Regulation;Resistance;response;Risk Factors;Role;Sgk protein;Signal Transduction;Site;Stimulus;Study of serum;Therapeutic;therapeutic target;therapeutically effective;tool;ubiquitin-protein ligase;Vascular blood supply;Ventricular;Work

PROJECT_TITLE: Regulation of SGK1-mediated Pathological Cardiac Hypertrophy by Non-Canonical ERAD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-R (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Microbiome

ORG_CITY: HANOVER

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE This work will characterize the regulation, activity, and assembly of the Bacteroidetes type VI secretion system, which is employed by highly abundant bacterial residents of the human gastrointestinal tract. Our findings will shed light on a process that gut-resident bacteria use to remain established during health and prevent colonization by invading pathogens during gastrointestinal disease.

PI_NAMEs: LATARIO, CASEY J (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Academia;Bacteria;bacterial community;Bacteroides fragilis;Bacteroidetes;Binding;career;Career Choice;Cell Death;Cell Proliferation;Cells;Colon;Complex;crosslink;Cytoplasm;Data;Docking;Educational process of instructing;experience;experimental study;Fractionation;Gastrointestinal Diseases;Gastrointestinal tract structure;Gene Expression;Genes;Gnotobiotic;Gram-Negative Bacteria;gut microbiome;gut microbiota;Head;Health;Human;in vivo;Individual;Invaded;Knowledge;Label;Left;medical specialties;member;Membrane;membrane model;Mentorship;Microbe;microbiome;Microfluidics;microorganism;Modeling;Monitor;Mus;Nature;novel;pathogen;Pathogenicity;predictive modeling;prevent;Process;protein complex;Protein translocation;Proteins;Proteobacteria;Regulation;Reporting;Role;scaffold;Scientist;Site;skills;Stains;Structure;System;Tail;Techniques;Testing;Tetracyclines;Training;Tube;Validation;Vibrio cholerae;Visualization;Work

PROJECT_TITLE: Defining the Bacteroidetes Type VI Secretion System MC-BP Interface and Regulation


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Food insecurity disproportionately affects people with diabetes mellitus and is associated with suboptimal diabetes self-management behaviors and poor diabetes outcomes such as hypoglycemia, poor glycemic control, and increased acute healthcare utilization. A diabetes self-management education and support program tailored to the needs of people with food insecurity may improve these outcomes. The proposed research will use quantitative and qualitative methods to determine the nutritional, behavioral, and psychological barriers to diabetes self-management for people with food insecurity and type 2 diabetes to inform the adaptation and development of a DSMES program tailored for this population.

PI_NAMEs: GU, KRISTINE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Address;Adherence;Adult;Affect;American;Anxiety;Behavior;Behavior Therapy;Behavioral;Blood Glucose;Budgets;Cardiometabolic Disease;Caring;Certification;Clinical;Clinical Investigator;cohort;Communities;Complement;cost;Data;design;Development;diabetes distress;diabetes educator;diabetes management;Diabetes Mellitus;diabetes self-management;dietary;Dietary intake;Dietitian;Disease Management;disorder prevention;Eating;Education;Educational Curriculum;Effectiveness;Electronic Health Record;Endocrinology;Ensure;Environment;Equity;Ethnic Origin;Evaluation;Evidence based program;experience;Fellowship;Food;food insecurity;food resource;Future;General Hospitals;Glucose;glucose monitor;glycemic control;Goals;Health;Health behavior;health care service utilization;Health Food;Health Personnel;Healthy Eating;High Prevalence;high risk;Household;Housing;Hypoglycemia;improved;improved outcome;Internal Medicine;Intervention;Interview;Investigation;K-Series Research Career Programs;Knowledge;Learning;Longitudinal cohort;Low income;low socioeconomic status;Massachusetts;meetings;Mental Depression;Mentorship;Metabolism;Methods;Monitor;mortality;National Research Service Awards;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Outcome;Participant;patient oriented;Patients;Persons;Pharmaceutical Preparations;Physicians;Population;Problem Solving;programs;Provider;psychologic;psychosocial;Qualitative Methods;Qualitative Research;Race;Research;Research Design;Research Methodology;Resources;Self Management;Self Medication;Services;skills;social;Standardization;Structure;Surveys;Target Populations;Testing;therapy design;therapy development;Titrations;Training;Transportation;Work

PROJECT_TITLE: Diabetes Self-Management Education and Support for People with Type 2 Diabetes Experiencing Food Insecurity: A Mixed Methods Study

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


PHR: Disruptions to gastrulation, namely the formation of the three main germ layers of the body, are a threat to reproductive success and children’s health. Mounting evidence points to metabolic environment as a key regulator of cell fate, yet even the impact of known epigenetically active metabolites like 2-hydroxyglutarate (2- HG) have yet to be interrogated in post-implantation development. By elucidating the impact of maternal 2-HG accumulation on mammalian gastrulation, this project will offer valuable insight into the role of metabolic environment in early development and reproductive fitness.

PI_NAMEs: BERGMANN, JENNA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: 3-Dimensional;Adult women;adverse pregnancy outcome;Affect;Age;alpha ketoglutarate;Bioenergetics;Biological Assay;Blood Circulation;cancer cell;career;Cause of Death;Cell Culture Techniques;Cell Death;Cell Differentiation process;cell fate specification;cell motility;Cells;cellular targeting;Child Health;Citric Acid Cycle;Clinical;cohort;Conceptions;Confocal Microscopy;critical period;cytotoxic;Data;Decision Making;Defect;Derivation procedure;Development;Developmental Biology;Developmental Delay Disorders;Developmental Process;disease-causing mutation;Ectoderm;Embryo;embryo cell;Embryonic Development;Endoderm;Environment;Enzymes;Epigenetic Process;Etiology;Event;Exposure to;Failure;Fluorescence;Fluorescent Probes;Future;gain of function mutation;Gastrula;gastrulation;Gene Targeting;Genetic;Genetic Models;genomic locus;Germ Layers;Goals;Heart Abnormalities;High Prevalence;histone methylation;histone modification;Human;Hypermethylation;Immunofluorescence Immunologic;implantation;in vivo;Inborn Errors of Metabolism;Induced Mutation;insight;Isocitrate Dehydrogenase;Life;Light;Malignant Neoplasms;Mediating;Mesoderm;Metabolic;Metabolic Diseases;Metabolic dysfunction;Methylation;Mitochondria;Modeling;Modification;Molecular;Molecular Target;Morphology;mouse development;Mus;mutant;Mutation;Neurologic;novel strategies;Organogenesis;Patients;Pattern;Physicians;Pregnancy loss;preimplantation;prevent;promoter;reproductive;reproductive fitness;Reproductive Medicine;reproductive success;Research;Resolution;response;Role;Scientist;Shapes;Site-Directed Mutagenesis;Somatic Mutation;Source;spatiotemporal;Specialist;Specific qualifier value;stem cells;Testing;Therapeutic Intervention;Time;Tissue-Specific Gene Expression;Tissues;tool;Training;tumorigenesis;Woman;Work

PROJECT_TITLE: Investigating how maternal metabolic dysfunction impacts mammalian gastrulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative  Up to 50% of the variance determining who develops Posttraumatic Stress Disorder following a severe trauma may be genetic; however, most successful analyses to date suggest that risk arises from multiple common genetic variants of small effect size, and that very large sample sizes will be needed for detection. This proposal aims to uncover the genomic architecture of PTSD through large-scale, collaborative genome- wide association studies. Identifying the pathways underlying PTSD will lead to an improved neurobiological understanding, enhanced prevention, and improved treatment of this debilitating and prevalent syndrome.

PI_NAMEs: KOENEN, KARESTAN C;NIEVERGELT, CAROLINE M (contact);RESSLER, KERRY J.;STEIN, MURRAY B.

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Acceleration;Address;African American;Alleles;analytical tool;Architecture;Awareness;base;Behavior;Biological;Biological Sciences;causal variant;cell type;Clinical;clinically relevant;Collaborations;Complex;Copy Number Polymorphism;Country;Data;Data Collection;Data Set;Detection;Development;Diagnosis;Disease;Ensure;Etiology;European;Evaluation;Exposure to;Foundations;Freezing;Funding;Future;Genetic;genetic architecture;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Goals;Heritability;Heterogeneity;high risk;Human Genetics;improved;Individual;International;Knowledge;Maps;Mediating;Mental disorders;Meta-Analysis;Modeling;Molecular;multi-ethnic;multiple omics;National Institute of Mental Health;Native American Ancestry;Nature;Neurobiology;novel;Outcome;Paper;Participant;Pathway interactions;Persons;phenomenological models;Phenotype;pleiotropism;polygenic risk score;Post-Traumatic Stress Disorders;Prevention;Productivity;Progress Reports;psychiatric genomics;Psychiatry;Publishing;rare variant;Recording of previous events;Research;Research Personnel;Research Priority;resilience;response;Risk;risk prediction;risk variant;Sample Size;Scientist;Signal Transduction;Single Nucleotide Polymorphism;Solid;Source;Specificity;Strategic Planning;Stress;success;Symptoms;Syndrome;Therapeutic;Time;Tissues;Trauma;trauma exposure;traumatic event;United States National Institutes of Health;Variant;Veterans;Vulnerable Populations;Work;working group

PROJECT_TITLE: Psychiatric Genomics Consortium for PTSD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-E (02)]


ORG_CITY: BALTIMORE

ORG_DEPT: PATHOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cancer patients being treated with immune checkpoint inhibitors may suffer from fatal myocarditis. We propose TIGIT as a novel therapy target to protect the heart from myocarditis. This could elucidate a new treatment option for cancer and non-cancer myocarditis patients.

PI_NAMEs: JAIME, CAMILLE  (contact)

PROJECT_TERMS: Ablation;adeno-associated viral vector;Adverse effects;anti-PD-1;Antibodies;antigen-specific T cells;Autoimmune myocarditis;autoreactive T cell;autoreactivity;cancer cell;cancer clinical trial;cancer immunotherapy;Cancer Patient;cancer therapy;Cardiac;Cardiovascular system;CD4 Positive T Lymphocytes;Cells;Cessation of life;Coxsackie Viruses;CTLA4 gene;Data;Death Rate;delivery vehicle;Disease;Eligibility Determination;Enterobacteria phage P1 Cre recombinase;Excision;experience;FOXP3 gene;Goals;Heart;Homeostasis;Immune;immune cell infiltrate;immune checkpoint;Immune checkpoint inhibitor;immune-related adverse events;Immunoglobulins;immunological intervention;Immunotherapy;improved;in vivo;Incidence;Inflammation;Inflammatory;ITIM;Knockout Mice;Malignant Neoplasms;Measures;Mediating;member;Monoclonal Antibodies;Mus;Myocarditis;Natural Killer Cells;neoplastic cell;new therapeutic target;Newly Diagnosed;novel;Oncology;overexpression;Pathway interactions;Patients;PDL1 pathway;Peripheral;peripheral tolerance;Plasmids;prevent;Prevention;Preventive measure;programs;promoter;Public Health;receptor;Regulatory T-Lymphocyte;Reporting;Research;response;Risk;Role;Self Tolerance;Severities;Severity of illness;Signal Transduction;Surface;T cell regulation;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;theories;Therapeutic;Treatment Protocols;tumor;Up-Regulation;Viral Vector

PROJECT_TITLE: TIGIT upholds peripheral tolerance in ICI-myocarditis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Supplement to Parent Grant Dysregulation of Cav1.2 by beta amyloid peptide The L-type Ca2+ channel Cav1.2 constitutes one of the most important influx pathways for Ca2+ into neurons. Ca2+ in turn is a potent regulator of neuronal excitability and gene expression. During our work on the role of b amyloid peptide 1-42 (Ab) on LTD via regulation of Cav1.2 by the beta 2 adrenergic receptor we realized that in adult mice standard LTD can only be induced during the active circadian phase of mice and requires the regulation of Cav1.2 by the b2 AR by its natural ligand, norepinephrine (NE), which mediates wakefulness. For the Supplement we propose to test whether LTD in adult mice has a circadian rhythm that is driven by the established increase NE during active (night) phase and acts via b2 AR – Cav1.2 signaling. This work will help elucidate molecular mechanisms that mediate alertness and are likely important for attention and constitute potential targets for treatment of ADHD.

PI_NAMEs: HELL, JOHANNES W (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Adrenergic Receptor;Adult;aged;alertness;Alzheimer's Disease;Amyloid beta-Protein;amyloid peptide;Attention;Attention deficit hyperactivity disorder;beta-2 Adrenergic Receptors;Brain;Chronic;circadian;Circadian Rhythms;Complex;Cyclic AMP-Dependent Protein Kinases;Dendrites;Electrophysiology (science);Gene Expression;Genetic Transcription;Hour;Image;Impairment;Ligands;Long-Term Depression;Long-Term Potentiation;Mediating;Molecular;Mus;neuronal excitability;Neurons;neurotoxicity;Norepinephrine;parent grant;Pathway interactions;peptide L;Permeability;Phase;Phosphorylation;Rattus;Receptor Signaling;Regulation;Regulator Genes;Role;Science;Senility;Serine;Signal Transduction;Surface;Symptoms;synaptic function;Testing;Wakefulness;Work


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SEATTLE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE The principal goal of the Simian Collective is to showcase the significance of nonhuman primates in neuroscience research, including the unique significance of nonhuman primates as translational models of human neurological and neuropsychiatric diseases, disorders, and healthy and impaired aging. The meeting is organized to emphasize that realizing the maximal impact of nonhuman primate models in the 21st Century necessitates complementing cutting-edge research with neuroethical considerations, as well as educating our young investigators and the broader scientific and general communities about the importance of nonhuman primate neuroscience research. This meeting will provide an important forum to build the community involvement needed to take these critical steps in the next chapter of the field and to train the next generation of nonhuman primate neuroscientists.

PI_NAMEs: BASSO, MICHELE A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Advocacy;Advocate;Aging;aging related disease;Articulation;Brain;career;Characteristics;Cognitive;Committee Members;Communities;community building;community engagement;community involvement;Complex;Country;design;Development;Disease;Education;Ensure;Environment;Ethical Issues;Ethicists;Ethics;expectation;experimental study;Exposure to;Faculty;Fostering;Funding;Future;Genetic;Goals;Health;healthy aging;Human;human model;Image;Injury;Investments;Learning;Left;Link;Medical;meetings;member;mid-career faculty;Minority;Modeling;Modernization;Molecular;Monkeys;Mus;Nervous System Disorder;neural;Neurologic;neuropsychiatric disorder;Neurosciences;Neurosciences Research;next generation;nonhuman primate;novel;pathological aging;Patients;Pennsylvania;Phylogenetic Analysis;Policy Maker;Postdoctoral Fellow;Primates;programs;Research;research and development;Research Personnel;Role;Science;Scientist;Seasons;senior faculty;Stress;Students;success;symposium;Talents;Technology;tool;Training;Translating;translational impact;translational model;Translational Research;Underrepresented Populations;United States;Universities;Woman;Work

PROJECT_TITLE: Simian Collective Conference

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (45)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  This project holds relevance for understanding basic mechanisms of steroid hormone-regulated plasticity in neural circuits that are responsible for sensory predictions. Completion of this work will provide insight into the effects of hormonal dysregulation in numerous psychiatric and neurological conditions, as well the neural basis of sensory prediction deficits observed in these same disorders.

PI_NAMEs: JARZYNA, MARTIN WILLIAM (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Action Potentials;Affect;Afferent Neurons;Androgen Receptor;Animals;Area;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;behavioral plasticity;Binding;Brain;Breeding;Cell Nucleus;Cells;Communication;Complement;coping;Data;Dedications;Development;Disease;Distant;Electric Fish;electric mormyrid;Electric Organ;Electricity;Electrophysiology (science);Ensure;Estradiol;Estrogen Receptors;experimental study;extracellular;Feedback;Fellowship;Fishes;Gene Expression;Genetic Transcription;Genomics;Glutamates;Goals;hindbrain;Hormonal;hormone regulation;Hormones;In Vitro;in vivo;insight;Investigation;Investments;Kinetics;male;Measures;Membrane;Modeling;Molecular;Mormyridae;Motor;Motor output;Nervous System;neural;neural circuit;Neurologic;Neurons;neurotransmitter release;novel;Output;Pathway interactions;Peripheral;Physiologic pulse;Physiological;Physiology;postsynaptic;presynaptic;Process;Production;programs;Property;receptor;receptor expression;Regulation;reproductive;Research;Research Activity;Research Personnel;response;Running;Schizophrenia;Science;Seasons;sensorimotor system;Sensory;sensory feedback;sensory input;Sensory Receptors;Services;sex;Shapes;Signal Pathway;Signal Transduction;Site;Skin;Social status;South American;Stereotyping;steroid hormone;Steroid Receptors;Steroids;Stimulus;Structure;Synapses;Synaptic Potentials;Techniques;Testing;Testosterone;Time;Training;Vertebrates;Whole-Cell Recordings;Work

PROJECT_TITLE: Steroid Hormone-Regulated Plasticity of Sensorimotor Integration Circuitry Supports Behavioral Change

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]