NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Physical Activity;Prevention

PROJECT_TERMS: Acceleration;Adherence;Advisory Committees;Alzheimer's disease related dementia;Basic Science;behavior change;Behavior Therapy;Benchmarking;cognitive enhancement;cognitive function;Collaborations;Communication;Communities;Consultations;Data Collection;Development;Documentation;Effectiveness;Ensure;Evaluation;Evidence based intervention;Feedback;Fostering;Foundations;Funding;Future;Goals;Government Agencies;Grant;improved;Industry;Information Dissemination;innovation;Institution;Institutional Review Boards;interest;Intervention;Knowledge;Lead;meetings;member;Methods;middle age;Modeling;Monitor;Monitoring Clinical Trials;Nonprofit Organizations;older adult;operation;Physical activity;Pilot Projects;Prevention strategy;Process;programs;Public Health;Public Health Practice;Reporting;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Shapes;Statistical Data Interpretation;Strategic Planning;Structure;Translational Research;Translations;Travel;trend;United States National Institutes of Health;Update;Work


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Physical Activity;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PI_NAMEs: CONROY, DAVID E. (contact)

PROJECT_TERMS: Adherence;Adult;Affective;Alzheimer disease prevention;Alzheimer's disease related dementia;Alzheimer's disease risk;Ambulatory Monitoring;Architecture;Artificial Intelligence;Association Learning;behavior change;Behavior Therapy;Budgets;Cellular Phone;Clinical Trials;Cognition;cognitive enhancement;cognitive function;cognitive testing;community advisory board;compliance behavior;conditioning;Development;digital;digital intervention;Engineering;Evaluation;exercise intervention;experience;Experimental Designs;experimental study;Expert Systems;Foundations;Future;generative artificial intelligence;Goals;Habits;Human;Impaired cognition;Intervention;intervention effect;Intervention Trial;Link;Long-Term Effects;longitudinal, prospective study;Measurement;Measures;Mediator;Medicine;member;Methods;middle age;Modeling;older adult;Outcome;Participant;Persons;Physical activity;post intervention;preservation;Prevention;Process;processing speed;prompt engineering;prototype;Publications;Randomized;recruit;Research;Residual state;Short-Term Memory;Source;Surveys;System;Target Populations;therapy development;Time;tool;translational pipeline;trial design;United States National Institutes of Health;Work

PROJECT_TITLE: Penn State Roybal Center for Promoting Adherence to Behavior Change and Enhancing Cognitive Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-4 (J3)]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal will interrogate a novel cell population identified in the developing human lung, referred to as Fetal Airway Secretory (FAS) cells, that are marked by SCGB3A2/SFTPB/CFTR. Since nothing is known about FAS cells, and there is no analogous population in the murine lung, the overarching goal of this proposal is to use an in vitro model of FAS differentiation to describe these cells in detail, to interrogate their differentiation potential, and to determine how they are regulated, thereby providing foundational descriptive and mechanistic insights into a new cell type in the human lung.

PI_NAMEs: SPENCE, JASON  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Administrative Supplement;Biology;Cell Maintenance;cell type;Cells;computerized tools;CRISPR interference;Cystic Fibrosis Transmembrane Conductance Regulator;Data;fetal;Gene Expression Profile;Genetic;Goals;Human;in vitro Model;insight;Location;loss of function;Lung;multimodal data;Mus;novel;Outcome;parent project;Population;progenitor;Regulation;Secretory Cell;stem cell differentiation;stem cell population;stem cells;transcription factor

PROJECT_TITLE: Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airway


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative This project aims to build a Diversity Center for Genome Research at Florida International University (FIU), which is the largest federally designated Hispanic-Serving Institution in the continental U.S. and one of the largest Minority-Serving Institution (MSI). The objectives of this proposal are consistent with the goals of the NIH full-scale Diversity Centers for Genome Research (DCGR) program and will have a significant impact on public health by providing cutting-edge genomic research projects, capacity building, and training in genomics at FIU. This multi-departmental project conducted by a diverse team of highly educated and experienced specialists will provide training and scholarship opportunities to 24 dual enrollment, undergraduate and masters students; training and graduate assistantships to 10 doctoral students; and pilot project grants to 15 early-stage investigators (assistant professors or postdoctoral fellows).

PI_NAMEs: BLACK, STEPHEN M;WANG, XUEXIA  (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Address;African American population;Assistantship;Award;Biomedical Research;career;career development;Caring;Classification;community engagement;Community Health;Community Health Education;community partners;County;Creativeness;demographics;Development;Discipline;Disease;disorder risk;doctoral student;Dual Enrollment;Education;equipment acquisition;ethical, legal, and social implication;ethnic minority;Evaluation;experience;Faculty;feasibility testing;Florida;Fostering;Genome;Genomic approach;Genomic medicine;Genomics;Goals;graduate student;Grant;Health;health disparity;High School Student;higher education;Hispanic Americans;Hispanic-serving Institution;HIV;Improve Access;improved;Individual;Infrastructure;innovation;Institution;Instruction;interest;International;Journals;lectures;Link;Measurable;Mental disorders;Mentors;Minority;minority communities;Minority Groups;Minority Health Research;Minority-Serving Institution;Mission;Modeling;Morbidity - disease rate;mortality;Multiomic Data;novel;Outcome;Participant;Patient Recruitments;Phase;Pilot Projects;Play;Population;Positioning Attribute;Postdoctoral Fellow;Procedures;professor;Prognosis;programs;Protocols documentation;Public Health;racial minority;recruit;Reduce health disparities;Research;Research Design;Research Personnel;Research Project Grants;research study;Resources;Risk;risk prediction;Role;Scholarship;social;Specialist;Students;Thinking;Training;Translating;Trust;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;underserved community;United States National Institutes of Health;Universities;Work;Workforce Development

PROJECT_TITLE: FIU-Diversity Center for Genomic Research (FIU-DCGR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: Chicago

ORG_DEPT: PHYSICS

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: We propose to develop a series of interactive content and video modules on program evaluation that can be used synchronously or asynchronously to train faculty and lead administrators in the biomedical sciences in effective and equitable evaluation of training programs. We further propose to test our content in five institutions, including an HBCU, with project-trained facilitators leading local learning communities. Our ultimate goal is to instill cycles of improvement based on a deeper understanding of trainee attitudes, behaviors and outcomes and thereby continue to shift the focus of all 1000+ biomedical training programs toward a trainee-centered learning environment, a process started by NIGMS 5 years ago.

PI_NAMEs: DRANE, DENISE L;GOLDBERG, BENNETT B (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Address;Administrator;Adopted;Attitude;Behavior;career;Chicago;design;Development;educational atmosphere;Educational workshop;Equity;Evaluation;Faculty;Feedback;Focus Groups;Funding;Funding Mechanisms;Goals;graduate student;Grant;Human;improved;Institution;institutional capacity;Lead;Learning;learning community;Learning Module;learning strategy;Measures;Modeling;National Institute of General Medical Sciences;Outcome;Participant;Performance;Persons;Phase;Process;Production;Program Evaluation;programs;Research;Role;Science;Series;Site;social capital;student training;success;Surveys;Teacher Professional Development;Testing;Training;Training Activity;Training Programs;training project;United States National Institutes of Health;Universities;Update;video module;Washington;Work;Workforce Development;Writing

PROJECT_TITLE: Training Modules to Enhance Institutional Capacity to Evaluate Training Programs in the Biomedical Sciences

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-U (RW)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation

ORG_CITY: WASHINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GALLAUDET UNIVERSITY

ORG_STATE: DC

PHR: Title: Fall Prevention in ASL-Using Deaf Older Adults  Findings from this culturally informed investigation will guide intervention strategies for improving balance and reducing risk of falls among community-dwelling Deaf older adults who use American Sign Language (ASL). The efforts to reduce fall risk will also promote healthy aging and quality life among Deaf older adults, population which has been little studied.

PI_NAMEs: TAMAKI, CHIZUKO  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Address;Adherence;adherence rate;Adult;age related;American Sign Language;Area;Awareness;Behavioral;Behavioral Risk Factor Surveillance System;bilingualism;Characteristics;Childhood;Communication;Communities;congenital deafness;Data;deaf;Deafblind;design;disabled;Doctor of Philosophy;Eligibility Determination;Enrollment;Equilibrium;exercise program;experience;Fall prevention;fall risk;falls;Focus Groups;Future;Gender;Genetic Transcription;Gerontology;Goals;graduate student;hard of hearing;Health;Health Personnel;Health Services Accessibility;healthy aging;Hearing;hearing impairment;high risk population;Home;improved;Incidence;Individual;Inequity;information gathering;Information Networks;Intervention;Interview;Investigation;Knowledge;Language;Life;Linguistics;Link;Mentors;Motivation;older adult;Older Population;Participant;Persons;Physical activity;Physical Education;Physical Fitness;Physiological;Policies;Population;Prevention program;Prevention strategy;Preventive care;Problem Solving;professor;programs;Quality of life;Recreation;Reporting;Research;Research Personnel;Resources;Rest;Risk Reduction;Safety;Science;Sensory;Services;Social Work;Societies;Students;success;support network;teacher;Time;undergraduate student;Vestibular dysfunction;vestibular system;Wellness Program;Work

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AI

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: OCCIDENTAL COLLEGE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because a fundamental understanding of second-line responses of macrophages to Group A Streptococcus will inform alternative means of treatment directed at enhancing the cellular response, toward the goal of limiting antibiotic usage. The proposed research is relevant to the part of NIH’s mission to enhance health and reduce the burdens of illness. The proposed research will be performed primarily by undergraduate students, achieving the objectives of the AREA program by engaging undergraduate students in biomedical research and encouraging them to consider careers in biomedical sciences.

PI_NAMEs: OKUMURA, CHERYL YM (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Antibiotic Therapy;Antibiotics;Antibody-mediated protection;antimicrobial;Bacteria;Bacterial Proteins;Binding;Biomedical Research;burden of illness;career;Caucasians;Cell Physiology;Cells;Cessation of life;Clinical;college;combat;Complex;Control Groups;Cytosol;Data;Development;Disease;DNA;Electron Microscopy;Environment;Enzymes;Exocytosis;exosome;experience;extracellular;Failure;Functional disorder;Goals;Health;Histones;Immune;Immune response;Impairment;improved;Infection;Inflammatory Response;innovation;Laboratories;lysosomal proteins;Lysosomes;Macrophage;Measurement;Measures;Membrane;Microscopic;Microscopy;Mission;Morphology;NAD+ Nucleosidase;NADP;NADPH Oxidase;new therapeutic target;Nonlytic;novel therapeutic intervention;Nuclear;Nuclear Envelope;Outcome;Pathology;Pathway interactions;Permeability;pharmacologic;Predisposition;prevent;Process;Production;programs;Proteins;Proteomics;Public Health;Reactive Oxygen Species;Refractory;Research;resilience;Respiratory Burst;response;Role;Science;Streptococcal Infections;Streptococcus pyogenes;Structure;targeted treatment;Testing;therapeutic development;Tissues;tool;Treatment Failure;treatment group;undergraduate student;United States;United States National Institutes of Health;Vaccines;Work

PROJECT_TITLE: Macrophage Second-line Responses to Group A Streptoccocus Infection

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Nutrition;Prevention;Women's Health Research

ORG_CITY: RICHMOND

ORG_DEPT: SURGERY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Data support the notion that critical events during pubertal mammary development may influence the breast microenvironment to increase breast cancer risk and promote tumor growth. Advanced glycation end-products (AGEs) are reactive metabolites produced during normal metabolism. Critically, disease states and lifestyle factors such as a sedentary lifestyle, obesity and poor diet increase AGE levels in the body. Our studies indicate that a high AGE diet during puberty disrupts mammary gland development to leave structures in the breast indicative of pre-neoplastic lesions. The objective of this study is to examine if increases in AGE levels during puberty represents a critical event during mammary development that increases future breast cancer risk and promotes tumor growth.

PI_NAMEs: FINDLAY, VICTORIA JANE (contact);TURNER, DAVID PAUL

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: adduct;Adult;advanced breast cancer;Advanced Glycosylation End Products;Alcohol consumption;Animal Model;Architecture;Atypical hyperplasia;Biological;Breast;Breast Cancer Patient;breast cancer progression;Breast Cancer Risk Factor;Cancer Burden;Carcinogens;Cells;Chemicals;Chronic;Circulation;Consumption;Cues;Data;Dependence;Development;Diet;dietary;Dietary Intervention;Disease;Duct (organ) structure;early life exposure;Energy consumption;Environmental Risk Factor;Epithelial Cells;Equilibrium;Estrogen Receptors;Event;Exercise;Exposure to;Fibroblasts;Food;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;glucose metabolism;Goals;Growth;high risk;Immune;in vivo;Inflammatory;inflammatory milieu;Ingestion;Intake;Intervention;Intraepithelial Neoplasia;Knockout Mice;late life;Lead;Lesion;Life;Life Style;lifestyle factors;Ligands;Link;Lymphoid;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Duct;mammary epithelium;Mammary gland;mammary gland development;Mammary Neoplasms;Mediating;Membrane;Metabolism;Modeling;Molecular;Morphology;mouse model;Mus;Myelogenous;Nature;Neoplasms;neoplastic;NF-kappa B;novel;Obesity;Oncogenic;Oxidative Stress;Paracrine Communication;pharmacologic;Play;Postmenopause;Predisposition;Process;Production;programs;protein crosslink;Proteins;Proto-Oncogene Proteins c-akt;Puberty;Publishing;receptor for advanced glycation endproducts;Receptor Signaling;recruit;Risk;Role;sedentary lifestyle;Signal Pathway;Signal Transduction;Smoking;STAT3 gene;Stress;Stromal Cells;Structure;sugar;Testing;Time;Tissues;Trees;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Tissue;tumorigenesis;tumorigenic;Unhealthy Diet;wasting;Woman

PROJECT_TITLE: Lifestyle associated reactive metabolites and their negative impact on breast cancer risk

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Disease or damage to the cerebellum results in a loss of motor coordination and motor learning. This proposal will broaden our understanding of the function of cerebellar output and how it contributes to the learning of new movements. The findings from this study with provide further insight into mechanisms of sensorimotor control to aid in the development of novel therapies for patients with movement disorders.

PI_NAMEs: DOBROTT, COURTNEY I (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acceleration;Address;Anterior;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Cell Nucleus;cell type;Cerebellum;Code;Compensation;Complex;Computer Models;Conditioned Stimulus;Deceleration;Development;Disease;Drops;Dysmetria;Electrophysiology (science);Ensure;Exhibits;experimental study;extracellular;Feedback;Forelimb;Generations;Goals;in vivo;Individual;insight;kinematics;Knowledge;Laboratory Finding;Learning;Lesion;limb movement;Limb structure;Location;Maps;Modeling;Motor;motor control;motor learning;Motor output;Movement;Movement Disorders;Mus;neural;Neurons;novel;novel therapeutics;optogenetics;Output;Patients;Policies;Positioning Attribute;Production;Role;sensorimotor control mechanism;Sensory;sensory feedback;Shapes;Signal Transduction;skills;Structure;Testing;Travel;Work

PROJECT_TITLE: The role of cerebellar output in the control of motor coordination


ADMINISTERING_IC: AA

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Substance Misuse

ORG_CITY: ALBUQUERQUE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF NEW MEXICO

ORG_STATE: NM

PHR: Project Narrative Risky drinking and alcohol use disorders (AUDs) have serious impacts on health and safety. Development of effective means to prevent negative consequences of heavy drinking, treat AUDs, and better understand the mechanisms that underlie behavior change have the potential to improve individual lives and enhance societal functioning. The proposed training program draws on multiple disciplines to prepare a new generation of researchers to investigate the psychological, social, and biological mechanisms that underpin processes of change; apply this knowledge to developing and testing new models for prevention and treatment; and apply these models to underserved populations.

PI_NAMEs: WITKIEWITZ, KATIE A (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TITLE: Alcohol Research Training: Methods and Mechanisms of Change


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Suicide

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT ABSTRACT Opioid misuse and its associated risks of suicide is a national public health emergency. Current estimates suggest that chronic pain impacts nearly half of Veterans, and studies have shown that people who experience chronic pain are at increased risk for a number of adverse health outcomes, including suicide and opioid overdose. Although multiple national initiatives within the Veterans Health Administration (VHA) have attempted to decrease the number of veterans with opioid prescriptions for pain management, these efforts focus on analyzing VA data only. Given that many Veterans receive care and treatment from non-VA community clinics and medical centers, it is imperative to study suicide or accidental overdose risk amongst Veterans with pain disorders by analyzing both VA and non-VA data. The overall objective of this proposal is to integrate large-scale VA and non-VA data across New York, Chicago and Florida to study the risk of suicidal ideation, suicide attempts, suicide and accidental opioid overdose deaths in Veterans receiving chronic opioid therapy (COT).

PI_NAMEs: OSLIN, DAVID W.;PATHAK, JYOTISHMAN  (contact)

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Accidents;Address;Age;alcohol misuse;Algorithms;Area;care fragmentation;Caring;Cessation of life;Chicago;Chronic;chronic pain;chronic pain patient;Clinical;Clinical Data;cohort;Communities;community clinic;Data;data integration;data modeling;Data Reporting;Data Set;data warehouse;deep learning model;deep neural network;demographics;deprivation;design;detection method;Electronic Health Record;electronic structure;experience;Feeling suicidal;Firearms;Florida;Funding;General Population;Health;Health behavior;Health Services Administration;Health system;Healthcare;Homelessness;indexing;Individual;innovation;Learning;Link;machine learning algorithm;machine learning method;machine learning prediction;Medical;Medical center;medical specialties;Medicare claim;Mental disorders;Morbidity - disease rate;mortality;mortality risk;Natural Language Processing;New York;New York City;novel;Opioid;opioid misuse;opioid mortality;opioid overdose;opioid therapy;opioid use;Outcome;overdose death;overdose risk;Pain Disorder;Pain management;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Predictive Analytics;prescription opioid;primary outcome;Provider;provider factors;Public Health;public health emergency;Research;Risk;risk mitigation;risk prediction;risk prediction model;secondary outcome;Site;social health determinants;sociodemographics;Source;Standardization;Structure;suicidal risk;Suicide;Suicide attempt;suicide rate;Text;Time;Veterans;Veterans Health Administration

PROJECT_TITLE: Linking VA and non-VA data to study the risk of suicide in chronic pain patients.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(90)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Lung Cancer;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Despite an increased understanding of the epidemiology of HPV+ HNC, the incidence of this cancer is rapidly rising and predictive biomarkers to guide treatment as well as HPV-selective therapies are lacking. To address this problem, we will apply innovative approaches to identify new therapeutic targets in HPV+ HNC. We will develop a mechanistic understanding of the role of these targets in HPV+ HNC and ultimately seek to translate our findings to clinical trials for patients suffering from this emerging cancer epidemic.

PI_NAMEs: GRANDIS, JENNIFER RUBIN (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Basic Science;boys;Cancer Etiology;cancer therapy;chemoradiation;Clinical;Clinical Treatment;Clinical Trials;Dependence;Disease;Epidemic;Epidemiology;Epidermal Growth Factor Receptor;ERBB3 gene;experience;Family member;functional genomics;Genitalia;Genomics;girls;Growth;Head and Neck Cancer;head and neck cancer patient;HPV positive;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Incidence;Individual;innovation;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mediating;Metastatic/Recurrent;Molecular;Morbidity - disease rate;multidisciplinary;Mutation;new epidemic;new therapeutic target;non-smoker;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;oral HPV-positive head and neck cancers;Pathogenesis;Patient Care;Patients;PIK3CA gene;PIK3CG gene;Positioning Attribute;Pre-Clinical Model;predictive marker;programs;Proteins;PTEN gene;Research;Role;Signal Transduction;Smoker;success;Translating;Translational Research;Vaccination

PROJECT_TITLE: Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy


ORG_CITY: IOWA CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative High blood pressure associated with obesity is a major public health concern because it promotes cardiovascular disease and stroke. The proposed study will investigate molecular- and circuit-level brain mechanisms that contribute to obesity-induced high blood pressure.

PI_NAMEs: LAULE, CONNOR  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adipocytes;Adult;Affect;Blood Pressure;blood pressure elevation;blood pressure reduction;blood pressure regulation;Brain;Brain Stem;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;cell type;Cells;Complex;conditional knockout;Data;diet-induced obesity;Disease;Economic Burden;electrical property;Electrophysiology (science);Energy Metabolism;experimental study;Fiber;FRAP1 gene;Functional disorder;Genetic Techniques;Goals;Health;Hormones;Hypertension;hypertensive;Hypothalamic structure;Impairment;in vivo;insight;Kidney;Knockout Mice;Learning;Leptin;leptin receptor;Leptin resistance;Maps;Melanocortin 4 Receptor;Metabolic;Methods;Molecular;Nerve;neural circuit;neurogenic hypertension;neuromechanism;Neurons;new therapeutic target;novel;Obese Mice;Obesity;obesity development;obesity treatment;Output;patch clamp;Pathway interactions;Photometry;Physiological;Population;preservation;Pro-Opiomelanocortin;Property;Public Health;Publishing;Regulation;Research;Role;Shapes;Signal Pathway;Signal Transduction;Stroke;Structure of nucleus infundibularis hypothalami;Synapses;System;Techniques;Testing;Thinness;Transgenic Mice;United States;Viral;Work

PROJECT_TITLE: Neural Mechanisms of Obesity-Induced Hypertension


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Obesity-linked adipocyte dysfunction drives the pathogenesis of metabolic disorders like type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). This project will apply an integrated phenotypic screening and chemical proteomics strategy to discover molecular pathways in adipocytes amenable to pharmacological modulation that may provide new approaches to revert obesity-induced adipocyte defects.

PI_NAMEs: JARIWALA, PARTH BALVANT (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adipokines;Adipose tissue;Automobile Driving;Biological;Biology;carboxylesterase;Chemicals;chemoproteomics;Chronic;Collaborations;Data;Defect;Deposition;Development;diet-induced obesity;Dinoprostone;Disease;Endowment;Energy Intake;Enzymes;Epidemic;expectation;Functional disorder;Genes;Genetic;glucose disposal;glucose tolerance;Goals;Heme;Hormones;Human;Hyperglycemia;Hyperlipidemia;improved;Inflammation;innovation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;insulin sensitizing drugs;Libraries;Ligands;Link;lipid biosynthesis;Lipids;Lipolysis;Liver;Mammals;Mass Spectrum Analysis;Mediating;member;Membrane;Metabolic;Metabolic Diseases;Metabolic Pathway;Molecular;Molecular Chaperones;Muscle;next generation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;novel therapeutic intervention;Nutrient;Obese Mice;Obesity;Oxidoreductase;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Play;Progesterone Receptors;Property;Prostaglandin Inhibition;Prostaglandins;protein function;Proteins;Proteome;Proteomics;Public Health;Role;screening;Serine Hydrolase;small hairpin RNA;small molecule;small molecule libraries;stereochemistry;Stereoisomer;Therapeutic;Tissues;tool;transcription factor;translational approach;Validation;Work

PROJECT_TITLE: Discovery of metabolic pathways using phenotypic screening and chemical proteomics


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

PHR: PROJECT NARRATIVE Neurodevelopmental disorders (NDDs) are a challenging set of conditions exhibiting broad phenotypic overlap with largely unknown etiologies. Reward system dysfunction is a hallmark of NDDs that confers significant impairment to those affected. This proposal seeks to delineate the molecular responses of dopamine receptor D1-expressing neurons, a key neuronal population responsible for processing rewards, in a mouse model for the study of NDDs.

PI_NAMEs: KELVINGTON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: 16p11.2;Address;Affect;Affinity Chromatography;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;behavioral phenotyping;Brain region;Calcium;Calcium Signaling;Cell Nucleus;Cell Physiology;Chronic;Consumption;Copy Number Polymorphism;Corpus striatum structure;Data;Disease;disease model;Dopamine;Dopamine D1 Receptor;effective intervention;Etiology;Exhibits;experience;experimental study;extracellular;Fiber;Fluorescence;Functional disorder;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomic Segment;Goals;histone modification;Histones;Human;Impairment;in vivo;Individual;insight;Intellectual functioning disability;Intervention;Knowledge;Learning;male;Mass Spectrum Analysis;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;Neurobiology;Neurodevelopmental Disorder;Neurons;neurotransmission;novel;Penetrance;Phase;Phenotype;Photometry;Play;Population;Post Translational Modification Analysis;Post-Translational Protein Processing;Process;Recurrence;Regulator Genes;Research;response;reward dysfunction;reward processing;Rewards;Ribosomes;Role;sex;Signal Induction;Signal Transduction;Sorting;Stimulus;Study models;Sucrose;Support System;Synapses;Techniques;Tissue-Specific Gene Expression;touchscreen;Transcript;transcriptome;transcriptome sequencing;Transgenic Animals;Translating;translatome;Work

PROJECT_TITLE: Defining the molecular impact of 16p11.2 deletion on reward response in striatal dopamine receptor D1-expressing neurons


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Toxic liver injury and acute liver failure represent severe health problems in the United States, and chronic liver injury predisposes to liver cancer, which has a very poor prognosis. Here, we will identify genes and pathways that can be exploited to accelerate regeneration of existing hepatocytes. We will also perform a comprehensive in vivo screen for inhibitors of liver cancer in order to develop novel therapeutics for this devastating disease.

PI_NAMEs: KAESTNER, KLAUS H (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Acceleration;acetaminophen overdose;Acute;Acute Liver Failure;acute liver injury;Attenuated;BAY 54-9085;Biological Models;cancer prevention;cancer risk;chronic liver disease;chronic liver injury;Clinical Treatment;Combined Modality Therapy;Complementary DNA;Data;Development;Disease;DNA;Early Diagnosis;effective therapy;Evaluation;FDA approved;Genes;Genetic;genetic approach;genetic makeup;Genetic Screening;Genotype;Grant;Growth;Health;Hepatic;hepatocellular carcinoma cell line;Hepatocyte;High-Throughput Nucleotide Sequencing;Human;improved;in vivo;Individual;inhibitor;Injury;innovation;Investigation;Knockout Mice;Length;Libraries;Liver;liver cancer model;liver cell proliferation;Liver diseases;Liver Extract;liver injury;Liver Regeneration;Malignant neoplasm of liver;Malignant Neoplasms;Maps;microRNA delivery;MicroRNAs;mimetics;Modeling;mouse model;Mus;Mutation;nanoparticle;Natural regeneration;Neoplasms;new combination therapies;novel;novel therapeutics;Oncogenes;Oncogenic;overexpression;Partial Hepatectomy;Pathway interactions;Patients;Pharmacotherapy;Phenotype;Plasmids;Population;Porifera;prevent;Prevention;Primary carcinoma of the liver cells;Process;Prognosis;Recovery;Resistance;response;Risk;Role;screening;small hairpin RNA;Survival Rate;Technology;Testing;The Cancer Genome Atlas;therapeutic target;Toxic Hepatitis;TP53 gene;Transforming Growth Factor alpha;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;tumorigenesis;Tyrosine Kinase Inhibitor;United States;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Innovative Genetic Approaches to Enhance Liver Repopulation and Reduce Cancer Risk and Progression

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) accounts for significant morbidity and mortality among persons living with HIV (PWH), even with sustained virologic suppression on modern antiretroviral therapy (ART). The gut mucosa is a key reservoir and site of ongoing immune dysregulation in ART-treated PWH. Using complementary expertise in HIV reservoirs and comorbidities, basic virology/immunology, and cardiovascular clinical/translational research, we propose to define how gut HIV persistence promotes mucosal immune dysregulation and bacterial translocation to drive inflammation and subclinical CVD, providing a framework to identify new therapeutic targets.

PI_NAMEs: GAVEGNANO, CHRISTINA ;LAHIRI, CECILE DELILLE (contact);PEREIRA RIBEIRO, SUSAN

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute myocardial infarction;aged;antiretroviral therapy;arterial stiffness;arterial tonometry;Automobile Driving;Bacterial Translocation;Biological Markers;Biometry;Blood specimen;Blood Vessels;brachial artery;C-reactive protein;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular imaging;Cardiovascular system;Carotid Artery Diseases;Carotid Atherosclerotic Disease;CD14 gene;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical;clinical research site;cohort;Cohort Studies;Communicable Diseases;comorbidity;cytokine;Data;density;Development;Disease;DNA;drug development;early onset;endothelial dysfunction;experience;Fibrin fragment D;Flow Cytometry;Functional disorder;Gastrointestinal tract structure;genetic signature;Goals;Gut Mucosa;high risk;high risk men;High Risk Woman;HIV;HIV Infections;Homeostasis;Immune;immune activation;immune reconstitution;Immunology;Impairment;improved;Individual;Inflammation;Inflammatory;Interleukin-6;Lamina Propria;Life Expectancy;Link;Lymphocyte;Magnetic Resonance Imaging;Measures;Mediating;metabolome;metabolomics;microbial;microbiome;Modernization;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;multidisciplinary;multiple omics;new therapeutic target;novel therapeutics;Organ;pathogen;Pathway interactions;Persons;Plasma;Play;Population;Prevalence;prevent;preventive intervention;programs;progression risk;recruit;Rectum;Residual state;restoration;Risk;Risk Factors;RNA;Role;Severities;Site;sudden cardiac death;Suspensions;systemic inflammatory response;Testing;Therapeutic Intervention;Time;Tissues;TNF gene;Translational Research;United States;Vascular Diseases;Vasodilation;Viral;Viral Load result;virology;Virus

PROJECT_TITLE: Elucidating the role of the gut reservoir and inflammation in driving cardiovascular disease among persons living with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE: Our proposed studies will investigate the mechanism by which BMAL1, alpha-1 antitrypsin, and cathepsin B regulate proteolysis and activity of the renal epithelial sodium channel and association with MARCKS protein leading to alterations in sodium retention and blood pressure as a function of time. The successful completion of these studies will help us understand mechanisms associated with sodium transport and blood pressure control over a 24 hour cycle and should result in the identification of novel drug targets and therapeutics for essential hypertension.

PI_NAMEs: ALLI, ABDEL AYUBE (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: absorption;Adaptor Signaling Protein;Address;Aldosterone;alpha 1-Antitrypsin;Anti-Hypertensive Agents;Apical;apical membrane;ARNTL gene;Attenuated;Binding;Biological Assay;Biotinylation;Blood Pressure;blood pressure control;blood pressure reduction;blood pressure regulation;Cardiovascular Diseases;cardiovascular risk factor;Caspase;Cathepsins B;Cause of Death;Cell membrane;Cells;circadian;circadian pacemaker;circadian regulation;Clock protein;comparison control;Data;density;Distal;Duct (organ) structure;Ductal Epithelial Cell;Electrolytes;epithelial Na+ channel;Equilibrium;Essential Hypertension;Etiology;Excretory function;Exhibits;experimental study;Female;Fluorescence Resonance Energy Transfer;Genes;Goals;Grant;Hour;Hypertension;In Situ;Infusion procedures;Investigation;Ion Channel;Kidney;Knockout Mice;Knowledge;male;MARCKS gene;Mass Spectrum Analysis;Measures;Mediating;Membrane;Metabolic;Molecular;Mus;Nephrons;new therapeutic target;novel;overexpression;Patch-Clamp Techniques;Pathogenesis;Peptide Hydrolases;Phase;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipids;Play;Post-Translational Protein Processing;Post-Translational Regulation;Potassium;Probability;protein expression;Proteins;Proteolysis;Proteome;Proteomics;Regulation;renal epithelium;Role;salt balance;Sex Differences;Sodium;sodium channel proteins;Telemetry;Testing;Therapeutic;Time;transcription factor;United States;Up-Regulation;urinary;Western Blotting;Wild Type Mouse

PROJECT_TITLE: The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney

STUDY_SECTION: HM

STUDY_SECTION_NAME: Hypertension and Microcirculation Study Section[HM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Adolescent Wellness Visits in Tanzania: Bundling evidence-based prevention services to increase uptake of HIV Testing and Counseling and other health services Adolescents are less likely to access prevention-oriented health services such as HIV testing and counseling (HTC) and contraception than adults, yet young people bear a disproportion burden of poor HIV and reproductive health outcomes in many low-resource settings. This study evaluates a new service delivery platform for reaching adolescents in Tanzania with HTC and other evidence-based screening services via clinic-based ‘Adolescent Wellness Visits’ coordinated between primary schools and health facilities that offer a package of youth-friendly services. We posit that by coupling sexual and reproductive health (SRH) services with non- SRH services such as nutrition, vision, dental and mental health screenings, applicable for all adolescents, adolescent health service use including HTC will increase and a tone will be set for a ‘culture of health and wellness’ during this critical developmental period.

PI_NAMEs: BAUMGARTNER, JOY NOEL (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: acceptability and feasibility;Adherence;Adolescence;Adolescent;Adolescent Health Services;Adult;Age;Ally;Area;behavioral health;behavioral outcome;Bundling;Caring;Clinic;Clinic Visits;Clinical;Collaborations;Consent;Consolidated Framework for Implementation Research;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost effectiveness;cost-effectiveness evaluation;Counseling;Coupling;critical developmental period;cultural health;design;Diagnostic;Dissemination and Implementation;Education;Eligibility Determination;evidence base;Evidence based intervention;Evidence based practice;Focus Groups;Friends;Future;Health;Health care facility;Health education;Health Promotion;health seeking behavior;health service use;Health Services;Health Services Accessibility;Health system;high risk sexual behavior;HIV;HIV-infected adolescents;Human immunodeficiency virus test;implementation research;implementation trial;improved;Individual;informant;Intervention;Interview;Letters;low and middle-income countries;Mental Health;Modeling;National Institute of Child Health and Human Development;neglect;Nurses;nutrition;Oral health;Outcome;Persons;pilot test;Policies;Population;pragmatic implementation;prevent;Prevention;prevention service;Preventive Health Services;Preventive service;primary outcome;Primary Schools;Provider;Puberty;Public Health;Randomized, Controlled Trials;Reproductive Health;Reproductive Health Services;Research;Resource-limited setting;response;Risk;Risk Assessment;Role;Schools;Science;screening;screening services;secondary outcome;service delivery;service utilization;Services;sexual and reproductive health;sexually active;sexually active adolescent;Sexually Transmitted Diseases;Shoulder;Site;Structure;Students;Tanzania;Testing;Time;Training;transition to adulthood;unintended pregnancy;Universities;uptake;Vision;Visit;Well Child Visits;wellness visit;Youth

PROJECT_TITLE: Adolescent Wellness Visits in Tanzania

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: This institutional training grant from the UCLA School of Dentistry aims to train the next generation of dentist- scientists and oral health scientists to conduct basic, translational, and clinical research, via a rigorous and interdisciplinary training program, to bolster a vigorous and diverse dental, oral and craniofacial research workforce.

PI_NAMEs: TON-THAT, HUNG  (contact);WONG, DAVID T

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Area;Basic Science;Biology;Biomedical Engineering;California;Cancer Biology;cancer cell;career;career development;Clinical Research;Comprehensive Cancer Center;Core Facility;craniofacial;Cryoelectron Microscopy;Dental;Dentists;Doctor of Philosophy;Engineering;Environment;Epigenetic Process;experience;faculty mentor;Genomics;Health;Healthcare;Image;improved;innovation;Institution;Link;malignant mouth neoplasm;medical schools;Mentors;Microbe;Molecular Biology;nanosystems;next generation;novel;Oral;Oral health;post-doctoral training;Postdoctoral Fellow;pre-doctoral;programs;Regenerative Medicine;Research;Research Personnel;Research Training;Resources;response;School Dentistry;Schools;Science;Scientist;Societies;stem cells;Training;Training Programs;translational genetics;Translational Research;Virulence

PROJECT_TITLE: UCLA Dentist-Scientist and Oral Health-Researcher Training Program


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DE PAUL UNIVERSITY

PHR: To examine the effectiveness of an evidence-based and culturally-grounded stress-reduction intervention (i.e., the A-CWS), facilitated by indigenous social workers, to increase adaptive coping and reduce active suicidal ideation in African American 9th graders. This study has broad public health implications and informs procedures for scaling up efficacious, high quality, and culturally grounded suicide prevention programs and best practices for the prevention of suicide among African American adolescents.

PI_NAMEs: ROBINSON, W LAVOME (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Adolescent;African American;Age;American;Anxiety;Applications Grants;Area;Cause of Death;Centers for Disease Control and Prevention (U.S.);Chicago;Child;Cities;Communities;community violence;coping;Coping Skills;Development;Dimensions;Educational Curriculum;Educational Intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;European;evidence base;experience;Family dynamics;Feeling hopeless;Feeling suicidal;Female;group intervention;health disparity;Health Professional;high risk;high school;Human Resources;Indigenous;Individual;informant;interest;Intervention;male;Mental Depression;Mental Health;Methods;Minority;Monitor;National Institute of Mental Health;Neighborhoods;ninth grade;Outcome;Participant;peer;Population Intervention;Prevention;prevention practice;Prevention program;Prevention strategy;preventive intervention;Procedures;Public Health;reducing suicide;Reporting;Resources;Risk;Risk Reduction;scale up;school based health center;Schools;Self Efficacy;Self-Injurious Behavior;service delivery;service providers;social interventions;social stigma;Social Workers;Stress and Coping;stress reduction;Students;Study Section;success;suicidal adolescent;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;Testing;Theoretical model;theories;Thinking;Training;translational study;Treatment Efficacy;Universities;violence exposure;Voice;Youth

PROJECT_TITLE: Preventing Suicide in African American Adolescents


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Nanotechnology;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE CAR T-cell immunotherapy has emerged as a successful therapy for relapsed and refractory leukemia, yet the patients' responses remains variable and unpredictable. Preclinical evaluation of CAR T-cells, as well as understanding how CAR T-cells dynamically interact with its neighbors via secretion of a broad range of functional cytokines can help improve the clinical outcomes of CAR T-cell immunotherapy. Herein, we will first propose the integration of novel nanoplasmon ruler sensor and microfluidic microwell array into a multi- parametric single-cell cytokine secretion and crosstalk analysis for preclinical evaluation and optimization of CAR T-cell immunotherapy.

PI_NAMEs: CHEN, PENGYU ;CHEN, WEIQIANG  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: acute T-cell lymphoblastic leukemia cell;Address;aptamer;B-Cell Acute Lymphoblastic Leukemia;B-cell precursor acute lymphoblastic leukemia cell;B-Lymphocytes;Behavior;Biosensing Techniques;Biosensor;Bone Marrow;cancer cell;CAR T cell therapy;CD19 Antigens;CD19 gene;Cell Communication;Cell Physiology;cell type;Cells;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;clinical practice;Communication;Complex;cytokine;Cytokine Network Pathway;cytokine release syndrome;cytotoxicity;design;Development;Diffusion;engineered T cells;Engineering;Enzymes;exhaustion;Fingerprint;Functional disorder;Hybrids;IL27RA gene;Immune;Immune signaling;Immunity;Immunologics;Immunosuppressive Agents;Immunotherapy;Impairment;improved;In Situ;Individual;individual variation;innovation;insight;Label;leukemia;Leukemic Cell;Location;Malignant Neoplasms;Maps;Measurement;Methods;Microfluidics;Monitor;nanoplasmonic;nanosensors;novel;Outcome;patient response;Population;practical application;pre-clinical;preclinical evaluation;Preventive treatment;Procedures;Production;programs;Refractory;Relapse;Research;Resistance;response;screening;sensor;sensor technology;Signal Pathway;Signal Transduction;spatiotemporal;success;Suppressor-Effector T-Lymphocytes;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Technology;temporal measurement;Therapeutic;therapy outcome;therapy resistant;Time;tool;Transportation;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Visualization

PROJECT_TITLE: Map Leukemia-immune Cell Talks with Nanoplasmon Ruler in CAR T-Cell Immunotherapy


NIH_SPENDING_CATS: Behavioral and Social Science;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE / RELEVANCE The Dietary Guidelines for Americans is the cornerstone of nutrition policy in the U.S., impacting WIC and other Federal nutrition assistance programs, health insurance incentives, weight and lifestyle interventions, policies to change the food environment, and nutrition education programs at the national, regional, state and local levels. This project will inform the next edition of the Dietary Guidelines by using cutting-edge analytic approaches to identify diet patterns that promote healthy outcomes of pregnancy. Although the causes of poor pregnancy outcomes are multifactorial, we focus on dietary intake because it is one of the few potentially modifiable risk factors, and has important implications for mother and child well beyond the childbearing years.

PI_NAMEs: BODNAR, LISA M (contact);NAIMI, ASHLEY ISAAC

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Accounting;adverse pregnancy outcome;Advisory Committees;American;Area;Birth;Characteristics;Charge;Child;child bearing;cohort;Complex;Conceptions;Congresses;Consumption;Data;Diet;dietary;Dietary Component;dietary control;Dietary Fiber;dietary guidelines;Dietary intake;Dietary Practices;disorder risk;Economics;Enrollment;Epidemiologist;evidence base;Female of child bearing age;Fetal Growth Retardation;flexibility;Food;food environment;Frequencies;Fruit;General Population;Gestational Diabetes;Guidelines;Health;Health Insurance;health of the mother;Health Promotion;healthy pregnancy;Heterogeneity;improved;Incentives;Infant Mortality;innovation;Knowledge;lifestyle intervention;Link;Literature;Machine Learning;machine learning algorithm;machine learning method;Maternal and Child Health;Medical;Methodology;Methods;Modeling;modifiable risk;Monitor;Mothers;Nulliparity;nutrition;nutrition education;Nutrition Policy;Nutritional;Nutritional Requirements;Nutritional status;Nutritional Support;Oils;Outcome;Outcome Study;Pattern;Planned Pregnancy;Policies;Policy Maker;Population;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;Premature Birth;programs;Prospective cohort;Prospective, cohort study;Public Health;Questionnaires;Recommendation;Research;Risk;Risk Factors;Risk Reduction;Sampling;Small for Gestational Age Infant;Special Supplemental Nutrition Program for Women, Infants, and Children;Specific qualifier value;Subgroup;synergism;Techniques;Time;Unhealthy Diet;United States Department of Agriculture;Variant;Vegetables;Weight;Woman;Work;working group

PROJECT_TITLE: Informing national guidelines on diet patterns that promote healthy pregnancy outcomes

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Nanotechnology;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: In this project we will carry out comprehensive mechanistic studies to evaluate and to optimize in situ gold biomineralization for efficient radiosensitization of pancreatic cancer to radiation therapy.

PI_NAMEs: CHO, SANG HYUN;KRISHNAN, SUNIL ;SOKOLOV, KONSTANTIN V (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acids;Address;Affect;Animal Model;aqueous;Biodistribution;Biological;biomaterial compatibility;biomineralization;Buffers;Bypass;cancer cell;Cancer Cell Growth;cancer radiation therapy;Cancerous;Carcinoma in Situ;Cell model;Cell Nucleus;Cells;Cellular biology;Characteristics;Clinical;clinical implementation;clinical translation;clinically relevant;Collagen;Complex;Computer Models;cytotoxic;Data;Desmoplastic;Development;Diffuse;Diffusion;DNA Damage;Dose;Drug Delivery Systems;Electrons;Environment;External Beam Radiation Therapy;Fluorescence;Fractionation;gastrointestinal;Glycosaminoglycans;Gold;Hafnium;Human;Hypoxia;improved;In Situ;In Vitro;in vivo;innovation;interest;interstitial;Ions;Kinetics;Laboratories;Laboratory Animal Science;Local Therapy;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Modeling;Modernization;Mucous Membrane;Mus;nanoGold;nanoparticle;nanoparticle delivery;Nanotechnology;Natural regeneration;neoplastic cell;Normal Cell;Normal tissue morphology;novel;novel strategies;Nuclear;Organ;Outcome;Oxides;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic PDX models;Penetration;Pharmaceutical Preparations;Physiological;Physiology;Probability;Process;programs;Proteoglycan;Radiation;Radiation Dose Unit;Radiation Interaction;radiation resistance;Radiation therapy;Radiation Tolerance;radioresistant;Radiosensitization;Recording of previous events;Reporting;restraint;Rheumatoid Arthritis;Roentgen Rays;Salts;Sodium Chloride;Solid Neoplasm;Spatial Distribution;Testing;Therapeutic;Therapeutic Agents;therapy outcome;Tissues;Traction;Transmission Electron Microscopy;Treatment-related toxicity;tumor;United States National Institutes of Health;Unresectable;uptake;X-Ray Computed Tomography

PROJECT_TITLE: In situ cancer cell specific biomineralization to overcome nanoparticle delivery barriers and sensitize pancreatic cancer to radiotherapy


ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Intracellular bacterial pathogens spread between host cells by targeting molecules critical to intercellular communication. Some forms of intercellular communication use membrane remodeling, mechanosensitive, and endocytic machinery to transfer cargo and exchange information between cells; processes that are still poorly understood, but are critical for development, tissue homeostasis, and barrier formation. This project will examine how a microbe hijacks these host pathways as it spreads through tissues, which will uncover fundamental mechanisms of host-microbe interactions, and reveal insights into the regulation of intercellular communication during normal or diseased states.

PI_NAMEs: LAMASON, REBECCA L (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Acceleration;Actins;Adhesions;Bacteria;Binding;Biological;Biology;Buffers;Cardiovascular Diseases;CAV1 gene;CAV2 gene;Caveolae;Caveolins;Cell Communication;cell fixing;Cell Physiology;Cell-Cell Adhesion;Cells;Cellular biology;Communication;Communications Media;Complex;Cytoskeleton;Development;Disease;Endocytosis;Eukaryotic Cell;Genes;Goals;Health;Homeostasis;host-microbe interactions;Human;human disease;human tissue;Image;Immunology;improved;innovation;insight;intercellular communication;Intercellular Junctions;knock-down;Life;Listeria;Listeria monocytogenes;Malignant Neoplasms;mechanical signal;Mechanical Stress;Mechanics;mechanotransduction;Mediating;Membrane;Microbe;microbial;Microscopy;Molecular;Molecular Probes;Motility;novel;Organelles;Organism;pathogenic bacteria;Pathway interactions;Polymers;Process;Protein Dynamics;Proteins;Quantitative Microscopy;recruit;Regulation;response;RNA Interference;RNA interference screen;Role;Shapes;Signal Transduction;Small Interfering RNA;spatiotemporal;Structure;Tail;Testing;Tissues;tool;Work

PROJECT_TITLE: Microbial Control of Host Intercellular Communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-B(02)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Neurosciences;Rehabilitation

ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Worldwide, nearly a half billion people suffer from a known disabling hearing loss, but a larger unknown number of people exhibit extended high-frequency hearing loss (hearing loss above 8,000 Hz). This research will provide valuable insight as to how extended high-frequency hearing loss affects one’s speech understanding in noisy environments and one’s awareness of their spatial surroundings.

PI_NAMEs: MONSON, BRIAN BRUCE (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: Acoustics;Adolescence;Adult;Affect;age related;American;Auditory;Auditory Perception;Auditory system;Awareness;Clinic;Clinical;Cochlea;Cochlear Implants;cohort;Communication;communication device;Complex;Cueing for speech;Cues;daily functioning;Databases;design;Device Designs;Disabling;Ear;Environment;Exhibits;experimental study;Face;Female;Frequencies;Goals;Head;Hearing;Hearing Aids;hearing impairment;hearing range;Hearing Tests;High-Frequency Hearing Loss;Human;improved;Individual;Individual Differences;insight;Length;Masks;Measures;National Institute on Deafness and Other Communication Disorders;Nature;neglect;Neurosciences;Noise;normal hearing;Oral cavity;Pattern;Performance;Persons;Phonetics;Population;Positioning Attribute;Presbycusis;Radiation;Reporting;Research;Research Personnel;segregation;Sex Differences;Signal Transduction;spectral energy;Speech;speech in noise;Speech Perception;speech recognition;Techniques;Technology;Testing;Time;Training;World Health Organization;young adult

PROJECT_TITLE: The ecological significance of extended high-frequency hearing in humans

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_CITY: BOYS TOWN

ORG_NAME: FATHER FLANAGAN'S BOYS' HOME

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Patients with hearing loss who use cochlear implants (CIs) show significant deficits and strong unexplained intersubject variability in their perception and production of spoken emotions in speech. This project will investigate the hypothesis that “cue-weighting”, or how patients utilize the different acoustic cues to emotion, accounts for significant variance in emotional communication with CIs. The results will focus on children with CIs, but parallel measures in postlingually deaf adults with CIs will be made, ensuring that results of these studies benefit social communication by CI patients across the lifespan by informing the development of technological innovations and improved clinical protocols.

PI_NAMEs: CHATTERJEE, MONITA  (contact)

PROJECT_TITLE: Perception and Production of Emotional Prosody with Cochlear Implants

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: LOS ANGELES

PHR: PROJECT NARATIVE This institutional training grant from the UCLA School of Dentistry aims to train the next generation of dentist- scientists and oral health scientists to conduct basic, translational, and clinical research, via a rigorous and interdisciplinary training program, to bolster a vigorous and diverse dental, oral and craniofacial research workforce.


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Lung;Lymphatic Research;Nanotechnology;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: In the proposed application, we will test our novel nanomedicine (MN-anti-miR10b nanodrug) capable of inhibiting the prometastatic miRNA-10b in large animals in vivo with the goal of regressing metastatic breast cancer and achieving a permanent cure. This proposal will serve as a last step before embarking on first-in- human studies.

PI_NAMEs: MOORE, ANNA  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: 4T1;Anatomy;Animal Model;Animals;Apoptosis;Area;arm;Biodistribution;Biomedical Research;bone;Brain;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;Breast Cancer Treatment;cancer therapy;cell killing;Cell Proliferation;Cell Survival;Cells;chemotherapy;Clinical;clinical implementation;clinical translation;Clinical Trials;Combined Modality Therapy;companion animal;Companions;Cytostatics;delivery vehicle;design;Dextrans;Dose;Drug Delivery Systems;Drug Kinetics;Family Felidae;first-in-human;Goals;Growth;Human;Human Development;human disease;human model;imaging capabilities;Immunocompetent;in vitro testing;in vivo;in vivo imaging;intravenous injection;Location;Lung;lymph nodes;Magnetic nanoparticles;Magnetic Resonance Imaging;Magnetism;MDA MB 231;Metastatic breast cancer;Metastatic Neoplasm to Lymph Nodes;Metastatic Neoplasm to the Lung;MicroRNAs;Modeling;Monitor;mortality;mouse model;Mus;nanodrug;nanomedicine;nanoparticle;nanotoxicity;Neoplasm Metastasis;neoplastic cell;novel;Organ;pharmacokinetics and pharmacodynamics;Pharmacotherapy;Phenotype;Physiological;Pilot Projects;pre-clinical;preclinical study;Property;Site;systemic toxicity;Technology;Testing;theranostics;Therapeutic;Therapeutic Studies;Time;Toxic effect;triple-negative invasive breast carcinoma;uptake

PROJECT_TITLE: anti-miR-10b Nanodrug for Treatment of Breast Cancer Metastasis: Study in Companion Animals

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Skin Cancer;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE  Non-viral gene delivery nanoparticles will be used to reprogram cancer cells into tumor-derived antigen- presenting cells (tAPCs). This method will take advantage of cancer cells' intrinsic expression of tumor antigens with innovations in nanomedicine to help train the immune system to recognize relevant antigens. This project will lead to a broadly applicable, innovative off-the-shelf technology and will also elucidate the biological mechanisms underlying this novel treatment strategy.

PI_NAMEs: TZENG, STEPHANY YI (contact)

PROGRAM_OFFICER_NAME: YOVANDICH, JASON L

PROJECT_TERMS: 4T1;Activated Natural Killer Cell;anti-cancer;anti-PD-1;anti-tumor immune response;Antigen-Presenting Cells;Antigens;Antitumor Response;Artificial nanoparticles;Biological;Blood group antigen S;cancer cell;cancer immunotherapy;Cancer Model;CD8-Positive T-Lymphocytes;CD80 gene;cell growth;Cell Reprogramming;Cells;Cellular immunotherapy;Circulation;Clinic;Clinical;clinical translation;Coculture Techniques;Complex;conventional therapy;cost;cytokine;Cytotoxic T-Lymphocytes;design;Distant;DNA;DNA delivery;efficacy evaluation;Engineering;Esters;experimental study;Formulation;Gene Transfer;Genes;Goals;IL18 gene;Immune;immune activation;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;immunogenicity;Immunologic Stimulation;Immunologics;Immunotherapy;improved;In Situ;In Vitro;in vivo;individual patient;Injections;innovation;Interleukin-1 alpha;Interleukin-12;Interleukin-15;Interleukin-2;interleukin-23;Intervention;Knowledge;Lesion;lymph nodes;Major Histocompatibility Complex;Malignant - descriptor;Malignant Neoplasms;MC38;Melanoma;Melanoma Cell;Methods;Modeling;Mus;nanomedicine;nanoparticle;nanoparticle delivery;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;next generation;non-viral gene delivery;novel;particle;Patients;Peptides;Plasmids;Population;prevent;Primary Neoplasm;Process;programmed cell death ligand 1;programs;recruit;Refractory;Signal Transduction;Specificity;Spleen;Synthetic Antigens;T cell response;T-Cell Activation;T-Lymphocyte;Technology;technology platform;Therapeutic;Tissues;TNFSF4 gene;Training;Transfection;Translations;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;tumor microenvironment;tumor specificity;Tumor-Derived;Work

PROJECT_TITLE: A PLATFORM TECHNOLOGY TO GENETICALLY REPROGRAM CANCER CELLS FOR ENHANCED IMMUNOTHERAPY

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Clinical Research;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Rotator cuff tears are a common source of pain and disability in the upper extremity. MRI is commonly used to evaluate rotator cuff pathology and to determine the treatment strategy, but the re-tear rate after surgical repairs is high, up to 57% in elderly patients. Here, we propose development of new, quantitative MRI techniques to evaluate degenerative changes in the rotator cuff tendons and muscles comprehensively, which may help to understand the process of rotator cuff muscle and tendon degeneration, to assess healing effects after surgery, and eventually to determine the optimal treatment strategy.

PI_NAMEs: HAN, MISUNG  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Age;American;Arthroscopic Surgical Procedures;Articular Range of Motion;Award;Biochemical;Biological Markers;Biology;Biopsy;Cells;Chemicals;Chronic;Clinical;Clinical Research;Collagen Fiber;Complication;design;Development;Diagnosis;disability;Elbow;Elderly;Encapsulated;Evaluation;Exhibits;Failure;Fatty acid glycerol esters;Fibrosis;functional outcomes;Goals;Grant;Harvest;healing;Histologic;Histopathologic Grade;human old age (65+);Image;imaging modality;imaging scientist;Imaging Techniques;improved;Infiltration;Information Systems;Injury;Intramuscular;Knowledge;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;mitochondrial uncoupling protein;Morphology;Mus;Muscle;muscle degeneration;muscle regeneration;Muscular Atrophy;Musculoskeletal;older patient;Operative Surgical Procedures;optimal treatments;Outcome;Pain;pain score;Pathology;Patient imaging;Patient Outcomes Assessments;Patient Recruitments;Patients;Physical Function;Physical therapy;Population;Process;Productivity;Quality of life;quantitative imaging;Recurrence;Relaxation;repaired;Reporting;Research;Research Design;Research Methodology;Research Project Grants;Rotator Cuff;rotator cuff tear;Sampling;Shoulder;Shoulder Pain;Site;Source;Statistical Data Interpretation;statistics;Structure;Surgeon;surgery outcome;Technical Expertise;Techniques;Tendon structure;Thick;Time;Tissues;Training;treatment strategy;uncoupling protein 1;Upper Extremity;Visual Analogue Pain Scale;Water

PROJECT_TITLE: Quantitative shoulder MRI for evaluating rotator cuff pathology


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Transport inside cells is driven by molecular machines called dynein and kinesin, which move along cellular tracks called microtubules. Defects in the transport machinery cause neurodegenerative and neurodevelopmental diseases in humans. This research will provide key mechanistic insights into how these machines work and how they are regulated to move dozens of cargos.

PI_NAMEs: RECK-PETERSON, SAMARA L (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Aspergillus nidulans;Binding;Biochemical;Cells;Chemicals;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoskeleton;Defect;dynactin;Dynein ATPase;Endosomes;Eukaryotic Cell;Family;fungal genetics;Genes;Genetic;genetic approach;Goals;Human;imaging genetics;In Vitro;insight;Intracellular Transport;Kinesin;Link;lissencephaly;live cell imaging;Melanophores;Melanosomes;Microtubules;Molecular;molecular imaging;Molecular Machines;Motility;Motor;Movement;Mutate;Mutation;Nature;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;ninein;Organelles;physical model;programs;Protein Engineering;Proteins;Proteomics;reconstitution;Regulation;Research;RNA Editing;Role;screening;single molecule;Specific qualifier value;Specificity;Structure;System;tool;Vertebrates;Visualization;Work;Xenopus laevis

PROJECT_TITLE: Mechanisms of microtubule-based transport

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Childhood Injury;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_DEPT: PHARMACOLOGY

ORG_STATE: PA

PHR: Narrative: Bronchopulmonary dysplasia remains a significant complication of prematurity, particularly extremely preterm infants and its management often includes the administration of systemic glucocorticoids (sGC), mainly dexamethasone (Dex). However, sGC therapy has been shown to carry significant concerns in neonates for not only short-term systemic side effects, but also detrimental long-term impact on structural brain development. This study seeks to determine whether the sGC prodrug, ciclesonide (CIC), will attenuate hyperoxia-mediated acute lung injury in neonates but NOT trigger the demyelination, astrogliosis, microglia activation or neuronal damage in neonatal brain caused by systemically administered sGCs such as Dex.

PI_NAMEs: DEFRANCO, DONALD B (contact);MONAGHAN-NICHOLS, A PAULA ;SAMPATH, VENKATESH

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 2 year old;5 year old;Academy;Acute;Acute Lung Injury;Address;Adrenal Glands;Adult;Adverse effects;Affect;Agonist;Air;Allergic rhinitis;Alveolar;American;Animal Model;Anti-Inflammatory Agents;Architecture;Asthma;astrogliosis;Attenuated;Behavior;Bone Growth;Brain;Bronchopulmonary Dysplasia;carboxylesterase;cell type;Cerebral Palsy;Child;Childhood;Clinical Practice Guideline;Clinical Trials;Complication;Demyelinations;Development;Dexamethasone;dosage;Dose;extreme prematurity;Fatty Acids;Fibrosis;Generations;Glucocorticoid Receptor;Glucocorticoids;Goals;Growth;Hyperoxia;In Vitro;Individual;Infant;Inflammation;Inhalation;Injury;innovation;Liquid Chromatography;long bone;Lung;lung injury;lung maturation;Mass Spectrum Analysis;Measures;Mediating;Microglia;Molecular;multidisciplinary;myelination;Neonatal;neonatal brain;Neonatal lung;neonatal lung injury;neonatal mice;neonate;Neurologic;Neurologic Effect;Neurons;novel;novel therapeutics;Oligonucleotides;Patients;Pediatrics;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Placebos;premature;Premature Infant;prevent;Prodrugs;Pulmonary Inflammation;randomized, clinical trials;Recommendation;Resolution;response;Risk;Rodent Model;side effect;single-cell RNA sequencing;Structure;targeted treatment;Testing;Therapeutic;transcriptomics;Vulnerable Populations

PROJECT_TITLE: A Safer Glucocorticoid to Treat Neonatal Lung Injury with Limited Adverse Neurologic Effects


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Hexokinase 2 (HK2), which catalyzes the first committed step in glucose metabolism, is not expressed in most normal tissues but is expressed at high level in cancer cells to accelerate glucose metabolism. Systemic HK2 deletion is tolerated and inhibits tumor progression and metastasis. New HK2 activities that promote cancer metastasis and resistance to immunotherapy are explored.

PI_NAMEs: HAY, NISSIM  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: A kinase anchoring protein;Ablation;Acceleration;Address;Adult;adverse outcome;Affect;Applications Grants;Binding;breast cancer metastasis;cancer cell;cancer therapy;Cell Survival;Cells;checkpoint therapy;Cyclic AMP-Dependent Protein Kinases;Cytotoxic T-Lymphocytes;fluorodeoxyglucose positron emission tomography;Gene Expression;Genetic;Glucose;glucose metabolism;Glucose-6-Phosphate;Glycogen Synthase Kinase 3;Glycolysis;glycosylation;Goals;hexokinase;Hexokinase 2;Histones;Human;Immunotherapy;Inhibition of Cancer Cell Growth;knock-down;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;MCL1 gene;Mediating;Metabolic;Metabolism;mouse model;Mus;neoplasm immunotherapy;Neoplasm Metastasis;neoplastic cell;Normal Cell;Normal tissue morphology;novel;Nutrient;Oxidation-Reduction;Phosphorylation;Phosphotransferases;Positron-Emission Tomography;programmed cell death ligand 1;Protein Kinase;Protein Subunits;Proteins;recruit;Regulation;Resistance;response;Role;scaffold;Scaffolding Protein;success;targeted cancer therapy;Tissues;tumor;tumor growth;tumor microenvironment;tumor progression;tumorigenesis

PROJECT_TITLE: Hexokinase 2 and cancer therapy

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Cancer

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Ubiquitin is a crucial post-translational modifier that regulates a great deal of eukaryotic cell physiology. This project aims to identify and structurally characterize ubiquitin-dependent protein-protein interactions. In doing so, this study will address a gap in current knowledge on how ubiquitin can mediate noncovalent regulation, interact with ubiquitin receptors, and reveal the structural basis of (poly)ubiquitination in the efforts to define its larger role in human health.

PI_NAMEs: PATEL, RISHI  (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: 26S proteasome;Address;Affect;Affinity;Amides;Amines;analog;aqueous;Attenuated;Azides;Binding;Binding Proteins;Binding Sites;Biochemical;Biology;Biophysics;Biotinylation;C-terminal;Cell Physiology;Chemicals;Chemistry;Code;Collaborations;Complex;Coupled;crosslink;Cysteine;Data;Deubiquitination;Development;Disease;DNA Repair;Elements;Enzymes;Eukaryotic Cell;experimental study;Genetic Code;Genus Mycobacterium;Goals;Health;Human;Inflammatory Response;insight;intein;interest;Investigation;Knowledge;Laboratories;Legionella;Life;Ligation;Link;Liquid Chromatography;Lysine;Malignant Neoplasms;Maps;Mediating;Methods;Modeling;Modification;Molecular;Molecular Conformation;mutation screening;Nerve Degeneration;NF-kappa B;Organism;Pacific Northwest;Pathogenesis;Peptides;Phenylalanine;Polymers;Post-Translational Protein Processing;Protein Chemistry;protein complex;protein function;protein protein interaction;Proteins;Proteome;Proteomics;Reader;receptor;reconstitution;Regulation;Reporting;Research;Role;Salmonella;Scheme;Shapes;Signal Induction;Signal Transduction;Site;Specificity;Structure;Surface;System;tandem mass spectrometry;Tyrosine;Ubiquitin;Ubiquitin family;ubiquitin-protein ligase;Ubiquitination;Virulence;X-Ray Crystallography

PROJECT_TITLE: Investigations into ubiquitin binding proteins using structure guided reactivity


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: Project Narrative The complex protein-based network that surrounds living cells, the extracellular matrix, is in many ways as important to organismal development and health as the cells themselves. Produced and continually modified by the underlying cells, the extracellular matrix provides structural support and conveys a wide range of information affecting nearly all aspects of cell behavior. Our studies seek to identify and characterize the genes and cellular processes responsible for generating, maintaining, and modifying this matrix, thereby revealing underlying mechanisms governing human development and disease.

PI_NAMEs: FAY, DAVID S (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Actins;Address;Affect;Animals;Apical;Basement membrane;basolateral membrane;Biochemical;Biological;Biology;Biomechanics;Caenorhabditis elegans;cell behavior;Cell Culture System;Cell Physiology;Cell Shape;Cells;Clathrin-Coated Vesicles;Data;Deposition;Development;Disease;Embryo;Embryonic Development;Endocytosis;Endothelium;enhancer-binding protein AP-2;Epidermis;Epithelium;Extracellular Matrix;Future;Genes;Genetic;Health;Human Biology;Human Development;human disease;In Vitro;in vivo;insight;Investigation;Link;Mammalian Cell;member;Mesothelium;Molting;Morphogenesis;Nematoda;Organism;Pathway interactions;Phosphorylation;Physiology;Play;polarized cell;Process;protein complex;Protein Family;Protein Kinase;Proteins;Regulation;Role;Signal Transduction;Surface;Tissues;trafficking;Tube;Work

PROJECT_TITLE: In vivo regulation of the extracellular matrix

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Many breast cancer survivors (estimated 70% in some studies) experience clinically significant depression and/or anxiety in the months and years after finishing cancer treatments. This research will build on the rigor of prior research to reduce breast cancer survivor depression and anxiety with a compassion meditation intervention called CBCT (Cognitively-Based Compassion Training) for online synchronous delivery that is also inclusive of informal caregivers (i.e., adult family members who live with and typically provide half the care for survivors).

PI_NAMEs: PACE, THADDEUS  (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Address;Adult;Aftercare;Anxiety;Attention;attentional control;Breast Cancer survivor;Cancer Survivor;cancer therapy;caregiver education;Caregiver well-being;Caregivers;Caring;chemotherapy;clinically significant;Cognitive;Cognitive Therapy;Compassion;Diffusion;digital technology;Distress;Diurnal Rhythm;Effectiveness;Ensure;Exhibits;experience;Family member;Feeling;Goals;Health education;Home;Hydrocortisone;improved;informal caregiver;Instruction;Internet;Interpersonal Relations;Intervention;Mediating;Mediator;Meditation;Mental Depression;Meta-Analysis;mindfulness;mindfulness meditation;Modality;negative affect;online intervention;Operative Surgical Procedures;Pathway interactions;Personal Satisfaction;Pharmacotherapy;Physical activity;Physiology;pilot test;primary outcome;psychological distress;Radiation;Randomized;recruit;remote delivery;Research;self-compassion;skills;social;Social isolation;Solid Neoplasm;Stress;Supportive care;Survivors;symposium;synchronous contact;synchronous delivery;Testing;Training;Work

PROJECT_TITLE: Leveraging social connection by including informal caregivers in an internet video conference-based compassion meditation intervention to reduce psychological distress in breast cancer survivors

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: RELEVANCE TO PUBLIC HEALTH The Knockout Mouse Phenotyping Program (KOMP2) seeks to create an encyclopedia of gene function for the ~20,000 genes in the mouse and to ultimately create a resource for understanding gene function in humans. The Jackson Laboratory (JAX) KOMP2 Phase 3 Center will contribute to this goal by efficiently generating and characterizing knockout lines and sharing functional data for 600 mouse genes. The JAX team will enhance the value of these data by linking them with current genetic and biological knowledge, enabling the scientific community to discover the roles of these genes in human health and disease.

PI_NAMEs: BRAUN, ROBERT E (contact);MURRAY, STEPHEN A;WHITE, JACQUELINE K

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Adult;Age;Alleles;animal data;animal resource;Archives;Award;Behavior;Biological;Biological Models;Biology;Body Composition;Body Weight;Breeding;Cardiovascular system;Catalogs;cohort;Collection;Communities;Complement;Complex;cost;cost effective;Coupled;CRISPR/Cas technology;Cryopreservation;Data;Data Coordinating Center;Databases;Deposition;Development;Disease;disease model;Drug Screening;Embryo;Encyclopedias;endonuclease;Engineering;Ensure;experience;Faculty;Fertility;Fortification;Future;gene function;Generations;Genes;Genetic;genome-wide;Genotype;Goals;Guide RNA;Health;Human;human disease;human model;imaging modality;improved;Infertility;Infrastructure;innovation;Institution;International;Internet;Knock-out;Knockout Mice;Knowledge;Laboratories;Leadership;Link;meetings;member;Metabolic;Methods;Mission;mouse genetics;mouse genome;mouse model;multidisciplinary;Mus;mutant;Mutant Strains Mice;new technology;novel;novel strategies;nuclease;offspring;old mice;Orthologous Gene;Partner in relationship;Pathway interactions;Phase;Phenotype;Physiological;preclinical study;Production;programs;Protocols documentation;Public Health;Publications;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Resources;Role;Services;sex;skills;social media;Standardization;Technology;Testing;The Jackson Laboratory;Time;tool;transmission process;United States National Institutes of Health;Work;young adult

PROJECT_TITLE: The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2)


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Kidney Disease;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Kidney cancer can run in families; however, in most families with multiple cases of kidney cancer, a specific causative gene cannot be identified. The goals of this project are to determine if inherited mutations in a gene called KEAP1 increases the likelihood of developing kidney cancer and to determine whether kidney cancers with mutations in KEAP1 may behave differently than other kidney cancers. A better understanding of the role of KEAP1 and other genes in the development of kidney cancers may lead to earlier identification of kidney cancers through screening and to better therapies for patients with kidney cancer.

PI_NAMEs: CARLO, MARIA  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Advisory Committees;Affect;Aggressive Clinical Course;Alleles;Antioxidants;Appointment;Award;Bioinformatics;Biological Models;Cancer Model;cancer predisposition;cancer prevention;cancer therapy;Cancer-Predisposing Gene;career development;cell growth;Cell Line;Clear cell renal cell carcinoma;Clinical;cohort;Collaborations;Core Facility;Cysteine;Development;Development Plans;Drug Targeting;Early identification;Ensure;experimental study;Family;Fumarate Hydratase;Fumarate Hydratase Deficiency;Fumarates;functional genomics;Funding;Future;Gene Expression Profiling;Gene Modified;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;Genetic Services;Genitourinary system;genomic profiles;Genomics;Germ Lines;Germ-Line Mutation;Glutathione;Goals;Hereditary Renal Cell Carcinoma;Heritability;Histologic;Histology;Human Resources;Immunohistochemistry;improved;In Vitro;in vivo;Individual;Inherited;Institution;interest;Laboratories;Lead;loss of function;Loss of Heterozygosity;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Medical Genetics;Medicine;Memorial Sloan-Kettering Cancer Center;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Methodology;Molecular;Mutate;Mutation;nephrogenesis;Neurofibromin 2;new therapeutic target;novel;Oncogenic;Oncology;Organoids;Pathologic;Pathway interactions;patient derived xenograft model;patient subsets;Patients;Phenotype;Positioning Attribute;predictive tools;Predisposition;Process;Prognosis;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Personnel;Resources;response;Risk;Risk Reduction;Role;Running;Scientist;screening;Screening for cancer;skills;Somatic Mutation;Susceptibility Gene;Syndrome;targeted exome sequencing;targeted treatment;Techniques;Testing;Training;transcriptomics;translational model;Translational Research;tumor;Tumor Suppressor Genes;tumorigenesis;United States;Up-Regulation;Variant;Work

PROJECT_TITLE: Investigating the Role of KEAP1 Germline and Somatic Mutations in Renal Cell Carcinoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Clinical Research;Health Services;Mental Health

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE The goal of this new T32 program is to provide postdoctoral training in embedded mental health services research leveraging the established infrastructure across the Mental Health Research Network (MHRN), a practice-based research network. The proposed program will offer postdoctoral fellows training and mentorship led by scientists embedded within MHRN health systems in close collaboration with stakeholders. During the 5- year award period, a total of 10 postdoctoral fellows will complete 2-year training programs, including didactics in health services research and mental health disorders, tailored mentorship in grant writing, professional development, project leadership, and multi-site research collaboration, and opportunities to conduct research and participate in ongoing activities across MHRN, in preparation for independent careers with the necessary training to conduct NIH-supported embedded mental health services research.

PI_NAMEs: AHMEDANI, BRIAN KENNETH (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Health system;Mental Health Services;Postdoctoral Fellow;Research Training

PROJECT_TITLE: Embedded Mental Health Services Postdoctoral Research Training in Health Systems


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: MOUNT PLEASANT

ORG_NAME: CENTRAL MICHIGAN UNIVERSITY

PHR: Project Narrative This project is relevant to public health because the development of tools and acquisition of knowledge related to bacterial trehalose metabolism will support the development of new strategies to detect and treat bacterial infections. This project focuses on an important class of trehalose-utilizing bacteria, mycobacteria, which include the tuberculosis-causing pathogen that kills 1.5 million people per year. Thus, this research is relevant to NIH’s mission in that its contributions in terms of technology and fundamental knowledge are ultimately expected to help understand and combat bacterial pathogens that have a major impact on human health.

PI_NAMEs: SWARTS, BENJAMIN MICHAEL (contact);WOODRUFF, PETER J

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acceleration;Address;Adoption;analog;Antibodies;Area;Award;Bacteria;Bacterial Infections;Basic Science;biocontainment facility;Biomedical Research;Catalysis;cell envelope;chemical synthesis;combat;Complex;Data;Development;diagnostic development;diagnostic strategy;Disease;drug efficacy;Drug resistance;Drug Tolerance;Environment;Genus Mycobacterium;Goals;Grant;Growth;Health;Human;Image;imaging probe;Immune Evasion;Immune response;Immunomodulators;Immunotherapy;Impairment;improved;inhibitor;innovation;Institution;Knowledge;Knowledge acquisition;Label;Lipids;Macrophage;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methods;Mission;Multi-Drug Resistance;mycobacterial;Mycobacterium Infections;Mycobacterium smegmatis;Mycobacterium tuberculosis;mycolate;novel;novel diagnostics;novel therapeutic intervention;novel therapeutics;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Permeability;Persons;Phagocytosis;Pharmaceutical Preparations;Pharmacotherapy;Physiology;Predisposition;Process;Public Health;Publishing;Reaction;recruit;Research;Research Activity;research facility;Rifampin;Role;targeted treatment;Technology;Therapeutic;therapeutic development;tool;tool development;Training;Translational Research;Trehalose;Tuberculosis;tuberculosis drugs;undergraduate student;United States National Institutes of Health;Virulence;Work

PROJECT_TITLE: Chemoenzymatic synthesis of trehalose analogues as tools for investigating mycobacteria

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Portland

ORG_NAME: ARONORA, INC.

ORG_STATE: OR

PHR: Project Narrative Myeloproliferative disorders (MPNs) are chronic bone marrow stem cell disorders that can lead to significant symptoms including abnormal blood counts, an enlarged spleen, and, in advanced cases, significantly shortened survival. While currently available treatments alleviate symptoms, they can have serious adverse effects, and do not significantly alter the course of the disease. To address this critical problem, we propose to develop AB062, a liver-targeted thrombopoietin gene antisense oligonucleotide (THPO-ASO) drug candidate that could provide a safer novel pharmacological treatment that may be able to alter the natural disease course for this small but severely ill patient population.

PI_NAMEs: LORENTZ, CHRISTINA U (contact);TUCKER, ERIK IAN

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: ABL1 gene;Address;Adverse effects;Alleles;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Biological;Blood;Blood coagulation;Blood typing procedure;Bone Marrow;Bone Marrow Stem Cell;Caring;Chronic;Chronic Myeloproliferative Disorder;Clinical;Clinical Research;Clinical Trials;Code;Data;deprivation;Development;Disease;Disease Outcome;Disease Progression;Dose;drug candidate;effective therapy;efficacy evaluation;Engineering;Engraftment;Erythrocytoses;Extrahepatic;Extramedullary Hematopoiesis;Funding;Gene Expression;Genetic;Genetic Transcription;Hematological Disease;Hematopoietic;Hematopoietic stem cells;Hemorrhage;Hepatic;Histologic;Histology;Human;improved;in silico;In Vitro;in vivo;industry partner;inhibitor;Innovative Therapy;Investigational Drugs;Investigational New Drug Application;JAK1 gene;JAK2 gene;Janus kinase;Legal patent;Letters;Leukocytosis;Libraries;Liver;Malignant - descriptor;manufacture;Marketing;Medical;Megakaryocyte Proliferation;Messenger RNA;mimetics;Modeling;Morbidity - disease rate;mortality;mouse model;MPL gene;Mus;mutant;Mutation;Myelofibrosis;Myeloproliferation;Myeloproliferative disease;neoplasm therapy;Neoplasms;novel;novel therapeutics;palliative;Papio;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phase;Phase II Clinical Trials;Phenotype;Platelet Count measurement;preclinical development;preclinical toxicity;Preparation;prevent;Primates;Process;product development;progenitor;prospective;Protein Tyrosine Kinase;Publishing;Quality of life;reduce symptoms;Refractory;Research;Research Personnel;Safety;screening;Serum;Signal Transduction;Site;Small Business Innovation Research Grant;small molecule;Splenomegaly;stem;stem cell exhaustion;stem cell expansion;stem cells;symptomatology;Symptoms;synergism;Therapeutic;Therapeutic Agents;THPO gene;Thrombocytopenia;thrombocytosis;Thrombopoietin;Toxic effect;Transgenic Organisms;transplant model;Treatment Efficacy;Work

PROJECT_TITLE: Thrombopoietin Targeting in Myeloproliferative Neoplasms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-C(10)B]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Racial/ethnic disparities are still prevalent for maternal and infant outcomes, and popular programs for vulnerable populations involve resource-intensive home visits or non-personalized health information materials. We propose the development of a chatbot that addresses both of these possible limitations by representing a scalable tool that can have widespread reach across geographies and is personalized and responsive to an individual’s specific informational needs. Results from our project can be utilized to inform strategies to reduce health disparities by lowering barriers to timely and verified health information.

PI_NAMEs: APARICIO, ELIZABETH MARIE;NGUYEN, THU  (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Algorithms;Anxiety;Appointment;Artificial Intelligence;Back to Sleep;Behavioral Sciences;Biometry;Breast Feeding;care outcomes;chatbot;Child;Childbirth;Communication;Communities;community clinic;Complex;computer science;Computer software;coping;cost;cost effective;design;Development;Discrimination;disparity reduction;Emergency department visit;Ensure;Epidemiology;ethnic disparity;ethnic minority;Ethnic Minority Women;Experimental Designs;Family;family support;flexibility;Focus Groups;Friends;Geography;Goals;Grant;Health;Health behavior;health care service organization;health organization;Health Professional;Home visitation;Hour;Immunization;improved;Individual;Infant Mortality;infant nutrition;infant outcome;Informatics;Internet;Intervention;Knowledge;Left;Libraries;Maternal and Child Health;Maternal Mortality;maternal outcome;Medical;Medicine;Methodology;Methods;Misinformation;Mothers;Natural Language Processing;new technology;open source;outcome disparities;Participant;patient oriented;personalized approach;phrases;Population;population based;Postpartum Depression;Pregnancy;Preventive;Procedures;programs;prototype;Public Health;Quality of life;racial disparity;racial health disparity;racial minority;racial minority women;Randomized;Randomized, Controlled Trials;recruit;Reduce health disparities;Resources;response;Risk;Role;Sampling;scale up;screening guidelines;stressor;Technology;Testing;Text Messaging;tool;Underserved Population;virtual;Visit;Vulnerable Populations;web page;Well baby checks;Well Child Visits;Woman;women of color

PROJECT_TITLE: Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication to Reduce Disparities in Maternal and Child Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-E(09)]