NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Infectious Diseases;Rare Diseases;Stomach Cancer

PI_NAMEs: BUSADA, JONATHAN  (contact)

PROJECT_TERMS: Acceleration;Adrenal Glands;Adrenalectomy;Affect;Anti-Inflammatory Agents;Atrophic Gastritis;Autoimmune;Automobile Driving;Cancer Etiology;Cancer Model;Cancer Patient;cancer risk;carcinogenesis;CD4 Positive T Lymphocytes;Cells;Cessation of life;Chronic;chronic inflammatory disease;Crohn's disease;cytokine;Data;Death Rate;Development;Diagnosis;diagnostic tool;Disease;Dysplasia;efficacy evaluation;Environment;Epithelium;Future;Gastric Adenocarcinoma;gastric cancer prevention;gastric carcinogenesis;Gastric Metaplasia;Gastric mucosa;Gastritis;Glucocorticoid Receptor;Glucocorticoids;Goals;Helicobacter;Helicobacter Infections;Helicobacter pylori;high throughput screening;Hormones;Human;Hyperactivity;Immune;immunoregulation;Infection;Inflammation;Inflammatory;Inflammatory Response;Insulin;Knowledge;Laboratories;Link;Malignant Neoplasms;malignant stomach neoplasm;Metaplasia;mouse model;Mus;novel diagnostics;novel therapeutic intervention;Pathogenicity;Pathway interactions;Phenotype;polarized cell;Population;Preneoplastic Conditions;prevent;Production;Publishing;recruit;Regulation;Resistance;response;Role;Sampling;Severities;Signal Pathway;Signal Transduction;spasmolytic polypeptide;steroid hormone;Steroid-resistant asthma;Stomach;Stomach Neoplasms;T-Cell Activation;T-Lymphocyte;Testing;Time;Tissues;transcriptome;tumor;tumor microenvironment

PROJECT_TITLE: Immune Regulation of Gastric Cancer


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Diabetes mellitus (DM) and hypertension (HTN) are two prototypical vascular diseases that ultimately lead to capillary dysfunction, capillary closure, ischemia and vision loss. Current clinical methods and diagnostics for staging these diseases are neither effective in detecting the earliest capillary changes nor in detecting incremental capillary changes (improvement or worsening) in later stages of the disease. The successful outcome of this proposal will develop and implement novel SD- and SS-OCTA based technology in human subjects to identify novel biomarkers of capillary loss or closure in DM and HTN to improve the diagnosis and management of disease by allowing direct evaluation of capillary changes and ischemia in a clinical setting.

PI_NAMEs: KASHANI, AMIR H (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: African American;Age;Angiography;Animals;arteriole;Background Diabetic Retinopathy;Biological Markers;Blindness;Blood capillaries;Blood flow;Blood Vessels;burden of illness;Childhood;Clinical;clinical examination;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Confounding Factors (Epidemiology);cost;Cost of Illness;cotton wool spots;Cross-Sectional Studies;Custom;Data;density;Detection;Development;Devices;Diabetes Mellitus;diabetic;Diabetic Retinopathy;Diagnosis;Diagnostic;Diameter;Disease;Disease Management;Dot Immunoblotting;Early Diagnosis;Engineering;Evaluation;Eye;Eye diseases;FDA approved;Fluorescein Angiography;Functional disorder;Funding;Gender;Goals;Heme;Human;human subject;Hyperoxia;Hypertension;Image;Impairment;improved;in vivo;innovation;Institutional Review Boards;Intervention;Intervention Trial;Ischemia;Latino;Light;Los Angeles;Measurable;Measurement;Measures;medical schools;Methods;Microscopic;minimal risk;Morphology;multi-ethnic;neovascularization;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Optical Coherence Tomography;Outcome;Pathologic;Patient Care;Perfusion;Physicians;Physiological;Population Study;potential biomarker;Preparation;Procedures;Protocols documentation;Publishing;Race;Research;Research Design;Research Personnel;Resolution;response;Retina;Retinal Diseases;Scientist;Severities;Source;Staging;Stimulus;Structure;Technology;Testing;Time;Tissues;United States National Institutes of Health;Vascular Diseases

PROJECT_TITLE: Assessment of Retinal Capillary Density, Morphology and Function in Retinal Vascular Disease Using Novel OCT Angiography Based Metrics


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Continued improvement in outcomes for pancreatic cancer patients requires recruitment and support of new independent investigators in the field of translational pancreatic cancer research. To accomplish this objective, the CEP will provide financial support, didactic training, and mentored research opportunities to promote multidisciplinary translational research as well as diversity through the recruitment of women, minority, and disabled faculty.

PI_NAMEs: GILLANDERS, WILLIAM E. (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Award;Basic Science;Biometry;California;Cancer Biology;Cancer Etiology;career;career development;Clinic;Clinical;Clinical Trials Design;Collaborations;Department chair;Development;Development Plans;Diagnosis;disabled;Discipline of obstetrics;Doctor of Philosophy;Early Diagnosis;Education;Educational Status;Ethics;Extramural Activities;Faculty;Feedback;Financial Support;Fostering;Funding;Gynecology;Image;improved;Institution;Leadership;Malignant neoplasm of pancreas;Malignant Neoplasms;Medicine;Mentors;Minority;multidisciplinary;Nebraska;next generation;North Carolina;novel strategies;novel therapeutic intervention;Outcome;Pancreas;pancreatic cancer patients;Patient Care;peer;Population Sciences;Prevention;Professional Competence;programs;recruit;Research;research and development;Research Personnel;Research Support;skills training;success;synergism;System;Training;Translational Research;Universities;Washington;Woman

PROJECT_TITLE: Career Enhancement Program


ADMINISTERING_IC: DK

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: NORTH CHARLESTON

ORG_NAME: SYLVATICA BIOTECH, INC.

ORG_STATE: SC

PHR: NARRATIVE Liver transplantation is the only treatment for the tens of thousands of patients suffering from liver failure in the U.S., yet thousands of potentially transplantable livers are discarded each year. The ability to preserve donor livers, and organs in general, could eventually be life-saving for hundreds of thousands, if not millions, of people around the world. To help overcome these barriers, we have developed a nature inspired, holistic solution to dramatically extend organ preservation times which has the potential to immediately make accessible lifepreserving liver transplants for emergency cases, while facilitating widespread banking of all types of organs and tissues in the future.

PI_NAMEs: BAICU, SIMONA C (contact);TAYLOR, MICHAEL JOHN;UYGUN, KORKUT

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Achievement;Acute Liver Failure;Affect;Animals;animation;Area;Arizona;Biological Assay;biomaterial compatibility;Biomedical Engineering;Biomedical Research;Businesses;Cells;Clinical;combinatorial;cost;Cryopreservation;Crystallization;Custom;Data;design;Devices;Dialysis procedure;Disparity;Drug Metabolic Detoxication;Economics;Emergency Situation;Equilibrium;Equipment and supply inventories;Evaluation;experience;flexibility;Freezing;Future;Goals;Graft Rejection;Growth;Heart failure;Helicopter;Hepatocyte;high throughput screening;Hour;Human;human model;Ice;Immune Tolerance;Immunologics;improved;In Vitro;Injury;Kidney;Kidney Failure;Kidney Transplantation;laboratory equipment;Learning;Length;Letters;Life;life span;Liver;Liver Failure;liver preservation;liver transplantation;Lobe;metabolic depression;Modeling;mortality;Nature;novel strategies;Operative Surgical Procedures;Organ;Organ Donations;Organ Preservation;Organ Procurements;Organ Transplantation;Outcome;Pancreas;Patients;Perfusion;Persons;Phase;preconditioning;preservation;Procedures;Protocols documentation;prototype;Quality of life;Rattus;Recovery;repaired;Resuscitation;Schedule;Slice;stress tolerance;Stretching;success;System;Technology;Temperature;Thermodynamics;Time;Tissue Engineering;Tissues;Translating;transplant model;Transplant Recipients;Transplant Surgeon;Transplantation;trauma care;Universities;Validation;ventricular assist device;Waiting Lists;Whole Blood;Work

PROJECT_TITLE: Extended preservation of human livers: a nature inspired, high subzero controlled, limited freezing approach


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in Autism Center at Columbia University will identify and study a diverse, population-based cohort of infants with monogenic risk for autism to evaluate the impact of early life identification of genomic risk variants on parent experience, neurodevelopmental trajectories, and prediction of autism diagnosis.

PI_NAMEs: CHUNG, WENDY K;VEENSTRA-VANDERWEELE, JEREMY  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 16p11.2;Acceleration;Address;Affect;Attitude;autism community;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic children;Behavioral;Brain;Caregivers;Child;Child Rearing;Clinical;Cognitive;cohort;Collaborations;Communication;Communities;Computer Analysis;congenital anomaly;Copy Number Polymorphism;Data Science;Data Set;Development;Diagnosis;Diagnostic Procedure;Doctor of Philosophy;Early Intervention;Eligibility Determination;Enrollment;Ensure;Ethnic Origin;Evaluation;exome sequencing;experience;Family;Foundations;Funding;genetic disorder diagnosis;genetic information;Genetic Risk;Genetic Screening;genetic variant;genome sequencing;genomic data;Genomics;high risk;improved;infancy;Infant;Inherited;innovation;Interdisciplinary Study;Intervention;Life;Matched Group;Measurement;Monitor;Neonatal Screening;neonate;neural;neurobehavioral;Neurosciences;New York City;Newborn Infant;Outcome;outreach;Parents;Pathogenicity;Pilot Projects;Policies;population based;Population Heterogeneity;prospective;psychosocial;Psychosocial Assessment and Care;Race;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Risk;risk prediction;risk variant;Self Efficacy;Sensory;Services;social;Socioeconomic Status;Standardization;Statistical Data Interpretation;Statistical Models;Systems Biology;Testing;trait;Universities;Variant;whole genome;Work


NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

PI_NAMEs: CHUNG, WENDY K (contact)

PROJECT_TERMS: Address;Administrative Efficiency;Administrator;Advisory Committees;autism spectrum disorder;Brain;career development;Child;Clinical;clinical practice;cohort;Collaborations;Communication;Communities;community advisory board;Computer Analysis;cost effective;Data;Data Set;Development;Diagnosis;Doctor of Philosophy;Early Diagnosis;Early identification;Ensure;Environment;Ethics;Evaluation;experience;Family;Fostering;Foundations;genetic information;Genetic Risk;Genomics;Goals;Hospitals;Individual;innovation;Institution;inter-institutional;Interdisciplinary Study;Intervention;Knowledge;Leadership;marginalization;Medical center;medical schools;meetings;member;Modeling;Monitor;multidisciplinary;neurobehavioral;New York;operation;outreach;Parents;pediatric department;Policies;Positioning Attribute;Presbyterian Church;programs;prospective;Psychiatry;Psychology;Publications;Quality Control;Recommendation;Research;Research Personnel;Research Project Grants;Resources;Seminal;Site;Statistical Data Interpretation;Strategic Planning;Structure;synergism;Systems Biology;Universities;Work

PROJECT_TITLE: Core A: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Activity of most genes in mammals are controlled by transcription factor proteins, which activate and suppress their target genes via epigenetic regulation without changing the DNA sequence. This regulation is best modeled by network models with directed edges from transcription factors to their target genes and many developmental processes and complex diseases are associated with dysregulation in these networks. In this proposed research program, we will develop a set of frameworks to model transcriptional regulatory networks at the cellular level with epigenetic data and use them to discover key regulators and therapeutic targets.

PI_NAMEs: UZUN, YASIN  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Architecture;ATAC-seq;Biological Models;bisulfite sequencing;Cell Differentiation process;cell type;Cells;Cellular Structures;ChIP-seq;Chromatin;Complex;Coupled;Data;Development;Developmental Process;Disease;DNA Methylation;DNA Sequence;dynamic system;Epigenetic Process;epigenetic regulation;epigenomics;Evolution;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Goals;histone modification;Mammals;Methods;Modeling;Nature;network models;organ growth;Pathway interactions;Population;programs;Proteins;Regulation;Research;Resolution;Systems Development;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Tissue Differentiation;Tissues;transcription factor;transcription regulatory network;Transcriptional Regulation

PROJECT_TITLE: Integrated frameworks for single-cell epigenomics based transcriptional regulatory networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

PI_NAMEs: VEENSTRA-VANDERWEELE, JEREMY  (contact)

PROJECT_TERMS: Advisory Committees;Affect;autism community;Autism Diagnosis;autism spectrum disorder;autism symptoms;autistic;Behavior Therapy;Biomedical Research;career;career development;Caregivers;Caring;Child;Clinical;clinical practice;cohort;Cohort Studies;Collaborations;Communication;Communities;community academic partnership;community advisory board;community engagement;Dedications;Development;Developmental Delay Disorders;developmental disease;Diagnosis;Discipline;Doctor of Philosophy;early childhood;Early Intervention;Education;Equity;Ethics;Evaluation;evidence base;experience;Family;family support;Fostering;Genetic;Genetic Risk;Genetic Screening;Goals;health care disparity;Individual;individuals with autism spectrum disorder;Infant;Infant Care;innovation;Knowledge;Language;Lead;medical schools;meetings;Mentorship;minority communities;Monitor;multidisciplinary;Neonatal;neurobehavioral;Neurosciences;New York;New York City;Newsletter;outreach;Parents;peer;Personal Satisfaction;Persons;Policies;Population Heterogeneity;Presbyterian Church;prospective;psychosocial;Publications;Race;Research;Research Personnel;Resources;Scientist;Screening Result;Series;service intervention;Services;socioeconomics;symposium;Time;Training;Translations;Underrepresented Minority;Universities;Update;web site;webinar;Woman;Work

PROJECT_TITLE: Core D: Dissemination and Outreach Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Immunotherapy;Skin Cancer

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PI_NAMEs: LIU, TRACY W (contact)

PROJECT_TERMS: Adjuvant;Animals;Benign;Biological Assay;Bioluminescence;Blood;Blood specimen;cancer immunotherapy;cancer therapy;Cell Communication;Cells;checkpoint therapy;Clinical;Disease;Disease Progression;enzyme activity;Enzyme Inhibitor Drugs;Enzymes;Evaluation;Female;Flow Cytometry;Genetic;Goals;Histamine;Histologic;imaging platform;Immune;Immune system;immunoregulation;Immunosuppression;Immunotherapy;improved;in vivo;inhibitor;intravital imaging;leukemia;male;Measures;Mediating;Melanoma;Metastatic Melanoma;Modeling;Molecular;monocyte;Mus;Myeloid Cells;Myeloid-derived suppressor cells;NADPH Oxidase;Nature;Neurodegenerative Disorders;neutrophil;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathologic;Pathway interactions;patient subsets;Patients;Peroxidases;pharmacologic;phase III trial;Phenotype;pre-clinical;Pre-Clinical Model;preclinical study;Primary Neoplasm;Reactive Oxygen Species;Research Project Grants;Resected;Resistance;Respiratory Burst;response;Role;Sampling;Source;success;Surface;therapy resistant;Time;Tissue Sample;Tissues;translational framework;Translations;Treatment Efficacy;treatment response;Tumor Escape;tumor growth;tumor microenvironment;Tumor Promotion;tumor-immune system interactions

PROJECT_TITLE: Targeting ROS enzymes in immunosuppressive myeloid cells to enhance immunotherapy


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Data Science;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Prevention

PI_NAMEs: WALL, MELANIE M (contact)

PROJECT_TERMS: Address;Age Months;Architecture;Area;Autism Diagnosis;autism spectrum disorder;Behavioral;behavioral outcome;biobehavior;Bioinformatics;Biological;Caregiver well-being;Caregivers;Child;Clinical;cohort;Collaborations;Complex;Computer Analysis;computerized data processing;computerized tools;Data;Data Analyses;Data Analytics;Data Collection;data infrastructure;data management;data quality;Data Science;data sharing;Data Storage and Retrieval;Databases;de novo mutation;Decision Making;Development;Doctor of Philosophy;Elasticity;Ensure;Equation;Evaluation;exome;experience;Family;Family Characteristics;Gene Frequency;Genetic;Genetic Annotation;genetic information;Genetic Models;genetic predictors;Genetic Risk;genetic variant;genome sequencing;genomic data;Genomics;Goals;Growth;Health;Heterogeneity;Infant;Infrastructure;innovation;insight;Lead;Leadership;Life;Machine Learning;Measurement;Measures;meetings;member;Methods;Modality;Modeling;multimodality;neurobehavioral;novel;Outcome;Participant;Pattern;polygenic risk score;Population;population based;predictive modeling;Procedures;Process;prospective;Psychopathology;quality assurance;rare variant;Recording of previous events;relational database;Reproducibility;Research;Research Personnel;Research Project Grants;resilience;Resources;Risk;Risk Factors;risk prediction;risk variant;Secure;social;Source;statistical and machine learning;Statistical Data Interpretation;Structural Models;Subgroup;success;Surveys;System;Testing;Time;Universities;whole genome

PROJECT_TITLE: Core B: Statistical and Computational Analysis Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: PROJECT NARRATIVE Rates of obesity for Black adolescents are among the highest of any racial or ethnic group in the United States, and loss of control over eating (LOC; being unable to control what or how much one is eating) confers greater risk for the development and maintenance of excess weight. The goal of the present study is to use a synthesis of qualitative data and ecological momentary assessment to understand the social contexts in which LOC occurs in Black adolescents, and specifically to probe the association between racial discrimination and LOC. This innovative research project has the potential to inform culturally-adaptive treatment and prevention programs that address both obesity and LOC and are effective in racial and ethnic minority youth.

PI_NAMEs: EGBERT, AMY  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent obesity;Area;Award;Behavior;Biomedical Research;Black race;Calories;career;Clinical;Communities;community involvement;community partnership;Consumption;contextual factors;coping;critical period;Data;design;Development;Distress;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;Environment;ethnic minority;Ethnic Population;excessive weight gain;experience;Exposure to;Family;Feeling;Focus Groups;Food;Future;Goals;health disparity;health equity promotion;Health Policy;Inequality;innovation;Intervention;intervention program;Language;Link;loss of control over eating;Maintenance;Measurement;Measures;Mentorship;Methods;Minority;minority children;Modeling;Motivation;Nature;Obesity;obesity prevention;obesity treatment;obesogenic;Overweight;peer;perceived discrimination;Persons;Population;Prevention program;programs;Protocols documentation;Public Health;Race;racial discrimination;racial disparity;racial minority;racial population;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;response;Risk;Risk Factors;Role;segregation;skills;social;Social Environment;Social Interaction;social situation;social stressor;Stress;stressor;Structural Racism;Time;Training;treatment program;United States;United States National Institutes of Health;Vulnerable Populations;Weight;Youth

PROJECT_TITLE: Examining Loss of Control Eating in Black Adolescents with Overweight/Obesity: The Role of Social Contexts and Racial Discrimination

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS ENGINEERING EXPERIMENT STATION

ORG_STATE: TX

PHR: Project Narrative This project aims to advance technology to monitor dietary intake in support of precision nutrition, which is important in managing many chronic conditions. An innovative combination of insertable and wearable devices with advanced computational methods is proposed to enable continuous or “on-demand” measurement of several metabolites and use them as nutritional biomarkers for estimation of macronutrient intake.

PI_NAMEs: DEUTZ, NICOLAAS E;GUTIERREZ-OSUNA, RICARDO ;MCSHANE, MIKE  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Address;Affect;Aging;Algorithms;American;Amino Acids;Biological Markers;Biomedical Engineering;Blood;Blood specimen;Body mass index;Calibration;Carbohydrates;Catheters;Chronic;Clinical Treatment;Collaborations;Communities;Complex;Computational algorithm;Computer Models;computer scientist;Computing Methodologies;Consumption;Continuous Glucose Monitor;Controlled Study;Data;data fusion;data streams;design;Development;Devices;Diabetes Mellitus;Diet;Diet Monitoring;Dietary intake;Digestion;Elements;Engineering;Evaluation;Exhibits;Fatty acid glycerol esters;Freezing;Glucose;glucose oxidase;Glucose Plasma Concentration;glucose sensor;Glycosylated hemoglobin A;Health;Hour;human data;human subject;Hydrogels;Individual;Injectable;innovation;insight;instrumentation;Intake;Intercellular Fluid;Kidney;Knowledge;Lead;Liquid substance;Liver Failure;Low income;machine learning algorithm;machine learning method;machine learning model;Macronutrients Nutrition;Measurement;Measures;Metabolism;Methods;Microdialysis;minimally invasive;Monitor;muscle form;Muscle function;Muscular Atrophy;novel;novel strategies;nutrition;Nutrition Monitoring;Nutritional;Obesity;Optical Readers;Optical reporter;Optics;Oxidases;Oxygen;Participant;Performance;Periodicals;personalized nutrition;Physical activity;Plasma;precision nutrition;predictive modeling;protein intake;Proteins;prototype;Proxy;Reader;Reporting;Research;Research Personnel;Sampling;sensor;sensor technology;sex;skin color;small molecule;Solid;success;Supermarket;System;Technology;Testing;tool;trend;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Minimally-invasive technology for personalized nutritional monitoring

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetic Testing;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

PI_NAMEs: KANNE, STEPHEN M (contact)

PROJECT_TERMS: Affect;Age;Age Months;Appointment;Attitude;Autism Diagnosis;Autism diagnostic;autism spectrum disorder;autism symptoms;Behavioral;Biological;Birth;Brain;Child;Childhood;Clinical;clinical care;clinical practice;Cognitive;cohort;Collaborations;Communication;Communities;comparison group;Computer Analysis;cost effective;Data;Decision Making;Development;Developmental Delay Disorders;Diagnosis;Diagnostic;Diagnostic Procedure;Doctor of Philosophy;Early Intervention;Elements;Ensure;Evaluation;experience;Funding;genetic disorder diagnosis;genetic information;Genetic Risk;genetic variant;genome sequencing;genomic data;Genomics;high risk;Hospitals;indexing;Infant;Information Centers;information gathering;Intervention;Knowledge;Language;Lead;Link;Matched Group;member;Molecular Genetics;Monitor;Neonatal Screening;Neurodevelopmental Disorder;New York;Newborn Infant;Outcome Measure;outreach;Parents;Participant;Personal Satisfaction;Phenotype;population based;Populations at Risk;predictive marker;Presbyterian Church;primary outcome;Procedures;prospective;Provider;Psychiatrist;Psychologist;Research;research clinical testing;Research Project Grants;Resources;Risk;risk prediction;risk variant;screening;Screening procedure;skills;Source;Standardization;Statistical Data Interpretation;Stress;Surveys;Training;Universities;whole genome

PROJECT_TITLE: Core C: Assessment Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Orphan Drug;Rare Diseases

PI_NAMEs: HU, GANGQING  (contact)

PROJECT_TERMS: Apoptosis;B-Lymphocytes;Binding;Binding Sites;Biological Process;Bone Marrow;Bone Marrow Neoplasms;CCAAT-Enhancer-Binding Protein-beta;Cell Line;Cell Proliferation;Cell Survival;Cells;chemotherapy;Chromatin;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Conditioned Culture Media;Data;defined contribution;Development;Diagnosis;Disease;DNA Sequence Alteration;Drug Compounding;Drug resistance;Engraftment;Enhancers;Epigenetic Process;epigenetic regulation;Exhibits;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Genome;genome-wide;genome-wide analysis;Genomics;Goals;Growth;Hematologic Neoplasms;Human;IL6 gene;immune modulating agents;immunodeficiency;improved;in vivo;innovation;Knowledge;Laboratories;lenalidomide;Leucine Zippers;Link;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;method development;Modeling;mouse model;Multi-Drug Resistance;Multiple Myeloma;multiple omics;Mus;novel strategies;novel therapeutic intervention;Osteoblasts;overexpression;Pathway interactions;Patients;Plasma;Play;pomalidomide;Prognostic Marker;programs;protective effect;Repression;Residual Neoplasm;Resistance;response;Role;Signaling Protein;Site;stem;Stromal Cells;Testing;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Treatment outcome;tumor;Tumor Burden;tumor microenvironment;Work;XCL1 gene

PROJECT_TITLE: C/EBPβ in bone marrow stromal cell-mediated drug resistance of multiple myeloma


PROJECT_TERMS: Architecture;autism spectrum disorder;autism symptoms;Behavior;Behavior Therapy;Behavioral;Brain;Categories;cohort;comparison group;Consent;Data;de novo mutation;Development;Diagnostic;Disease;Doctor of Philosophy;Down's Syndrome;Early Intervention;Education;Evaluation;exome sequencing;Family;family burden;Family member;Foundations;Genes;Genetic;genetic disorder diagnosis;Genetic Models;Genetic Risk;genetic testing;genetic variant;genome sequencing;genomic data;Genomics;Goals;Heritability;high risk;improved;improved outcome;Individual;individuals with autism spectrum disorder;Infant;Inherited;Intellectual functioning disability;Knowledge;Lead;Life;Methods;Neonatal Screening;neurobehavioral;neurogenetics;New York City;Newborn Infant;novel;Outcome;Parents;Pilot Projects;polygenic risk score;Population;population based;Predisposition;prospective;Quality of life;rare variant;Recording of previous events;Research;Risk;Risk Factors;risk prediction;risk variant;Self-Injurious Behavior;tool;Variant

PROJECT_TITLE: Project 1: Identifying and optimizing monogenetic risk prediction for autism in newborns


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetic Testing;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: APPELBAUM, PAUL STUART (contact)

PROJECT_TERMS: Abbreviations;Affect;Age Months;Age of Onset;Anxiety;Autism Diagnosis;autism spectrum disorder;autism symptoms;Behavioral;biobehavior;Caregivers;Child;Child Development;Child Rearing;clinical diagnosis;cohort;Collaborations;Color;Communication;Computer Analysis;Data;data sharing;Decision Making;Diagnosis;Diagnostic;Doctor of Philosophy;Early Intervention;emotional reaction;Emotions;Evaluation;expectation;experience;Family;Family dynamics;Feeling hopeless;follow-up;Funding;Future;Genes;genetic disorder diagnosis;genetic information;Genetic Risk;Genetic Screening;genetic testing;genetic variant;genome sequencing;Genomics;Guilt;help-seeking behavior;Impairment;Individual;Infant;Interdisciplinary Study;internalized stigma;Intervention;Interview;Lead;Learning;Life;Link;Matched Group;Measures;Medical;Monitor;Neonatal Screening;Neurodevelopmental Disorder;Newborn Infant;outreach;parent project;Parent-Child Relations;Parents;Pathogenicity;Personal Satisfaction;policy implication;population based;Predisposition;prospective;psychosocial;Reaction;reproductive;Research;Research Personnel;response;Risk;risk prediction;risk variant;Sampling;satisfaction;Severities;social;Statistical Data Interpretation;Stress;Surveys;Symptoms;Test Result;Time;Treatment/Psychosocial Effects;Uncertainty;whole genome

PROJECT_TITLE: Project 2: Psychosocial impact of autism genetic risk information on parents


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Cost Effectiveness Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: A team of investigators with a track record of collaboration and relevant expertise is proposing a Clinical Validation Center with two specific aims that are intended to validate blood based biomarkers and artificial intelligence based analysis of CT images as means to improve lung cancer screening. CVC investigators bring in substantial accomplishments relevant to the goals of the CVC as well as substantial resources in the form of several lung cancer screening cohorts with imaging data and blood samples to contribute to the success of the CVC in achieving its goals.

PI_NAMEs: HANASH, SAMIR M (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Accounting;Address;Artificial Intelligence;Benign;Bioinformatics;Biological Markers;biomarker discovery;biomarker panel;biomarker validation;Biopsy;Blinded;Blood specimen;blood-based biomarker;CA-125 Antigen;cancer biomarkers;Cancer Center;Cancer Detection;Cancer Diagnostics;Cancer Intervention and Surveillance Modeling Network;cancer risk;cancer statistics;Characteristics;circulating biomarkers;Classification;Clinical;Clinical Data;Clinical Trials Design;cohort;Collaborations;computed tomography screening;Computer Models;cost effectiveness;Cost Effectiveness Analysis;Data;deep learning model;demographics;Diagnosis;diagnostic accuracy;Early Detection Research Network;Eligibility Determination;Epidemiology;follow-up;France;Frequencies;Funding;Goals;Guidelines;Health Care Costs;Image;Image Analysis;imaging biomarker;improved;Individual;Institution;International;Longitudinal cohort;low dose computed tomography;Lung;lung basal segment;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;meetings;Modeling;models and simulation;Nodule;Performance;performance tests;personalized screening;Phase;phase 3 study;Population;precision oncology;Process;Prospective cohort;protein biomarkers;Publishing;Pulmonary Emphysema;Pulmonary Surfactant-Associated Protein B;Pulmonology;radiomics;Research Personnel;Resources;Risk;Risk Assessment;Risk Factors;risk prediction model;Sampling;screening;screening guidelines;screening program;Sensitivity and Specificity;Smoking History;Stage at Diagnosis;success;Testing;Tumor stage;United States Preventative Services Task Force;Validation;validation studies;Work;X-Ray Computed Tomography

PROJECT_TITLE: Clinical Validation Center for Lung Cancer Early Detection


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

PI_NAMEs: AMSO, DIMA  (contact)

PROJECT_TERMS: Age Months;Anxiety;Attention;Auditory;Auditory area;Autism Diagnosis;autism spectrum disorder;autism symptoms;Autonomic nervous system;Behavior Therapy;Behavioral Symptoms;Brain;Brain Stem;Cities;Classification;Cognitive;cohort;Communication;Complex;Computer Analysis;contextual factors;Data;design;Development;Diagnosis;Diagnostic;Doctor of Philosophy;Early Diagnosis;Early Intervention;Electroencephalography;Ethnic Origin;Evaluation;experience;Facial Expression;Family;fetal;Foundations;Frequencies;Future;gaze;gene environment interaction;Genetic;Genetic Risk;Genetic Screening;Gestational Age;Goals;grasp;heart rate variability;high risk;Hypersensitivity;individuals with autism spectrum disorder;Infant;infant outcome;information gathering;innovation;Intervention;joint attention;Knowledge;knowledge integration;Language;Language Development;Lead;Life;Locomotion;Measures;Motor;Movement;multidisciplinary;multisensory;Musculoskeletal Equilibrium;neural;neurobehavioral;neurodevelopment;Neurophysiology - biologic function;Newborn Infant;Nonverbal Communication;operation;Outcome;outreach;Parents;Pathway interactions;Pattern;Perception;Phenotype;Play;postnatal;Process;prospective;Race;Relative Risks;resilience;response;Risk;risk variant;Role;Sample Size;Sampling;Science;Self Efficacy;Sensory;service intervention;sex;Shapes;sleep quality;social;social communication;Social Development;sound;Statistical Data Interpretation;Statistical Models;Stimulus;sustained attention;System;Techniques;Temperament;Vision;Visual;Visual attention;Visual Cortex

PROJECT_TITLE: Project 3: Developmental trajectories in infants at genetic risk for autism


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Contraception/Reproduction;Endometriosis;Nanotechnology;Pain Research;Women's Health Research

ORG_CITY: CORVALLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative (Public Relevance Statement): Endometriosis affects ~10% of childbearing-age women and 35–50% of women with pelvic pain or infertility. Despite advances in medical treatment, there is no cure for this disorder. We propose a novel therapeutic approach based on magnetic nanoparticles that can specifically accumulate in endometriotic lesions following systemic administration and eradicate the disease by generating therapeutic temperatures (> 43 0C) inside the lesions upon exposure to the external magnetic field.

PI_NAMEs: SLAYDEN, OV D;TARATULA, OLEH  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Abdomen;Ablation;Address;Affect;angiogenesis;Animal Model;Animals;Binding;Biodistribution;Blood Vessels;cancer cell;cancer site;cancer therapy;Cancerous;cell type;Cells;Chemotherapy and/or radiation;Clinical;design;Development;Disease;Encapsulated;Endometrial;endometriosis;Endometrium;Engraftment;Excision;Exposure to;Extravasation;Female of child bearing age;Goals;Greater sac of peritoneum;Heating;Human;Hyperthermia;In Vitro;Infertility;Injections;Intervention;intravenous injection;invention;iron oxide nanoparticle;KDR gene;Lesion;Macaca;Macaca mulatta;Macrophage;magnetic field;Magnetic nanoparticles;magnetic therapy;Magnetism;Malignant Neoplasms;Mammalian Oviducts;Mediating;Medical;Menstruation;Modeling;monocyte;multidisciplinary;Mus;nanocluster;nanomedicine;nanoparticle;nanoparticle delivery;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;overexpression;particle;Patients;Pelvic Pain;Peptides;Permeability;Polymers;Predisposition;Primary Neoplasm;Primates;receptor;Recurrence;Recurrent disease;Research;Research Personnel;Safety;safety testing;SCID Mice;Shapes;Site;Specificity;Stromal Cells;subcutaneous;Surface;T-Lymphocyte;targeted delivery;Temperature;Testing;theories;Therapeutic;therapeutic nanoparticles;Tissue Transplantation;Tissues;Toxic effect;Transplantation;Treatment Efficacy;tumor;Uterus;validation studies;Woman;Xenograft procedure

PROJECT_TITLE: Development of magnetic hyperthermia for the systemic treatment of endometriosis


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Heart and lung disease are leading causes of morbidity and mortality in the United States with some populations having especially high burdens. Implementation strategies are needed to overcome barriers in order to effectively deliver evidence-based interventions to these high burden communities. The UNC Research Coordinating Center will provide organization and encourage synergies to enrich the research conducted at the Implementation Research Centers that aims to reduce or eliminate health disparities in heart and lung disease.

PI_NAMEs: STEVENS, JUNE  (contact);TRUESDALE, KIMBERLY P

PROGRAM_OFFICER_NAME: KHAN, SHAHNAZ

PROJECT_TERMS: Adopted;Ancillary Study;behavior change;cardiovascular health;Cardiovascular system;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community burden;conflict resolution;Data;Data Analyses;Data Element;Data Pooling;Data Set;design;Development;disorder risk;disparity elimination;Dissemination and Implementation;Education;Educational workshop;ethnic disparity;Evidence based intervention;Expedite Dissemination;experience;Funding Opportunities;Goals;health disparity;Heart Diseases;implementation research;implementation science;implementation strategy;improved;Intervention;intervention program;Knowledge;Lead;Lung Diseases;lung health;Measures;meetings;member;Mentors;Morbidity - disease rate;mortality;Multicenter Studies;multilevel analysis;National Heart, Lung, and Blood Institute;North Carolina;Performance;Persons;Population;prevent;Prevention Research;Procedures;programs;Publications;Recording of previous events;Reporting;Research;Research Activity;Research Design;Research Personnel;research study;Resources;Scientist;skill acquisition;skills;Specific qualifier value;Standardization;Statistical Data Interpretation;Structure;synergism;Terminology;Testing;Training;United States;Universities;virtual;web site;Work

PROJECT_TITLE: Coordinating Center for the DECIPHeR Network


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative Targeted Neural Text Summarization of Electronic Medical Records to Improve Imaging Diagnosis Relevant information from a patient's medical history is essential to allowing specialists (such as radiologists) come to accurate diagnoses; unfortunately, this key information is often buried in the unstructured clinical notes within patient Electronic Health Records (EHRs), making it difficult to find and draw upon to inform diagnosis. We propose to design and evaluate novel Natural Language Processing methods that provide focussed extractive summaries of the text within patient EHR to aid radiologists performing imaging diagnosis and counteract the cognitive biases of radiologists (while our focus is on radiology, the proposed approach will generalize to other specialties, providing a potentially novel and impactful means for domain experts to better harness EHR to improve care). We will assess whether and how these automatically generated summaries affect diagnosis in a pilot user study, providing insights into how (interactive) machine learning models might influence clinical practice.

PI_NAMEs: WALLACE, BYRON CASEY (contact);YOUNG, GEOFFREY

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: accurate diagnosis;Affect;Area;Automated Abstracting;Caring;Clinical;clinical center;Clinical Data;clinical decision-making;clinical diagnostics;clinical practice;Cognitive;Collaborations;Communication;Computerized Medical Record;Consult;contextual factors;Data;Data Science;Decision Making;Dedications;design;Diagnosis;Diagnostic;Diagnostic Errors;Diagnostic Imaging;Differential Diagnosis;Distant;Electronic Health Record;Feedback;Glean;heuristics;Hospitals;Image;Image Analysis;impression;improved;insight;Machine Learning;machine learning model;Measures;Medical;Medical History;Medical Imaging;medical specialties;Methods;Modeling;Modernization;MRI Scans;multimodality;natural language;Natural Language Processing;neural;novel;Output;Patients;Performance;point of care;Probability;prototype;Provider;Publishing;radiologist;Radiology Specialty;Recording of previous events;Records;recruit;Reporting;Research;Retrieval;Running;self supervised learning;Source;Specialist;Supervision;Surface;System;Text;Therapeutic;Thinking;Time;Training;unstructured data;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: Targeted Neural Text Summarization of Electronic Medical Records to Improve Imaging Diagnostics

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Center Overview: Project Narrative American Indians and Alaska Natives (AI/ANs) exhibit high rates of diabetes and serious, debilitating comorbidities, the treatment of which consumes a large share of increasingly scarce health care resources. This Center promotes research and builds capacity that promises to redress these disparities.

PI_NAMEs: BREGA, ANGELA GWEN;MANSON, SPERO MARTIN (contact)

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: 19 year old;20 year old;Address;Age;Alaska Native;American;American Indians;Area;base;Blood Glucose;Blood Pressure;Budgets;care costs;career;Cause of Death;Center for Translational Science Activities;Cessation of life;Cholesterol;Clinical;Collaborations;Colorado;Communities;community engagement;Community Outreach;community setting;comorbidity;Congresses;Consultations;Consumption;Country;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diagnosis;disease classification;Disparity;dissemination science;Effectiveness;End stage renal failure;Ensure;ethnic minority;ethnic minority population;evidence base;Exhibits;Faculty;faculty research;Funding;General Population;Goals;Health;health disparity;health literacy;Health system;Health Technology;Healthcare;Heart Diseases;high risk;implementation science;improved;Incidence;Infrastructure;innovation;Intervention;Knowledge;Learning;limb amputation;Lower Extremity;Medical;member;Mission;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Native-Born;Nature;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;Policies;Population;premature;Premature Mortality;Prevalence;Process;programs;Provider;Qualitative Research;Race;racial minority;racial minority population;Research;research faculty;Research Methodology;Research Personnel;Resources;response;Risk;Risk Factors;Rural Population;Satellite Centers;Sister;Special Population;Structure;Students;Training;Translating;Translational Research;translational research program;treatment program;United States Indian Health Service;Universities;Work

PROJECT_TITLE: Center for American Indian and Alaska Native Diabetes Translation Research (CAIANDTR)


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Leveraging novel population-representative survey and time diary data collected during the COVID-19 pandemic and the co-occurring period of intense racial trauma from the NICHD-supported National Couples’ Health and Time Study (NCHAT), the only fully-powered, multi-method study of American couples that includes fully- powered samples of racial and ethnic minorities and sexual minorities, the current study aims to identify mechanisms underlying gender, racial and ethnic minority, and sexual minority disparities in parenting stress and parental well-being. As part of the Social, Behavioral, and Economic Research on COVID-19 Consortium Coordination Center (SBECCC), the NCHAT data, the contextual data on structural racism, sexism, and heterosexism produced for this project, and the NCHAT survey items for harmonization will be shared with the SBECCC and the wider health research community to enable further understanding of the health and well-being impacts of the pandemic for underserved and vulnerable populations in particular.

PI_NAMEs: KAMP DUSH, CLAIRE M (contact);MEIER, ANN M

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Acute;Address;adverse childhood events;American;anti-Asian;Asian;Behavioral;Black race;Child;Child Health;Child Rearing;Communities;Coronavirus;Couples;COVID-19;COVID-19 pandemic;Data;diaries;Discrimination;Disparity;Economics;Environment;ethnic minority;experience;Exposure to;Family;Food;Funding;Future;Gender;Gender Identity;gender minority;Hate;Health;Home;improved;Income;Individual;innovation;Intention;Intervention;Latinx;Life Cycle Stages;Link;marginalization;Measures;Mediating;Mediator;Mental Health;Methods;Mothers;National Institute of Child Health and Human Development;novel;Occupations;pandemic disease;pandemic impact;pandemic stress;Parent-Child Relations;Parents;Personal Satisfaction;Police;Population;population based;Process;promote resilience;psychological distress;Psychological Stress;public health emergency;Race;racial identity;racial minority;racism;Research;resilience;Resources;Respondent;response;Risk;Sampling;Sampling Studies;Sexism;sexual identity;sexual minority;sexual minority disparity;social;Social isolation;social stigma;Socioeconomic Status;Stress;Structural Racism;success;Surveys;Testing;Time;Time Study;Trauma;Underserved Population;Violence;Virus;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Unequal Parenthoods: Population Perspectives on Gender, Race, and Sexual Minority Disparities in Family Stress and Health During Crises


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: MANSON, SPERO MARTIN (contact)

PROJECT_TERMS: Administrative Coordination;Advisory Committees;Alaska Native;American Indians;Appointment;Area;Award;Budgets;Center for Translational Science Activities;Collaborations;Colorado;Communication;Communities;community engagement;Community Outreach;community partnership;cost effective;data exchange;data sharing;design;Diabetes Mellitus;Dissemination and Implementation;Ensure;Evaluation;Goals;Health;Human Resources;implementation facilitation;Information Dissemination;Infrastructure;innovation;Institutionalization;interest;Knowledge acquisition;Lead;Leadership;Medical;meetings;Mission;Monitor;Needs Assessment;operation;organizational structure;outreach;Policies;Preparation;Prevention;Process;programs;Public Health Schools;Qualitative Research;Regulation;Research;Research Methodology;Research Support;Resources;response;Satellite Centers;senior faculty;Sister;Structure;success;Technology;Training;Translating;Translational Research;United States Indian Health Service;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Physical Activity;Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: B. PROJECT NARRATIVE Resistance training is a popular exercise modality for individuals across the lifespan and of all body types; however, the role of resistance training on measures of cardiovascular and metabolic disease is not known. This research will 1) develop and validate an epidemiological instrument to collect resistance training volume, 2) assess the effect of resistance training volume on estimates of insulin resistance and blood pressure, and 3) determine the optimal ratios for physical activity for improved estimates of insulin resistance and blood pressure. This research has to potential to inform future tailored intervention studies to target specific measures of cardiovascular and metabolic disease.

PI_NAMEs: BOOKER, ROBERT EDWARD (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: active lifestyle;Adult;Aerobic;Aerobic Exercise;Affect;Age;age group;Area;Award;Behavior;Biometry;Blood Pressure;Body Composition;Body System;Body Weight decreased;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Career Transition Award;Cell Size;Characteristics;Clinical Research;cohort;Data;Data Analyses;Development;Disease Management;disorder prevention;disorder risk;Dose;Educational Status;Effectiveness;Epidemiology;epidemiology study;Equilibrium;Exercise;experimental study;fitness;Frequencies;Future;Glucose Transporter;glucose uptake;GLUT 4 protein;Goals;Guidelines;Health;Health behavior;Health Promotion;Hypertrophy;improved;Individual;Institution;instrument;Insulin;Insulin Resistance;insulin sensitivity;Intervention Studies;Joints;Laboratories;Life Cycle Stages;life span;Linear Regressions;Longterm Follow-up;Measures;Medical History;medical schools;Mentors;Metabolic;Metabolic Diseases;minority investigator;Modality;mode of exercise;Motor;Movement;Muscle;muscle hypertrophy;Outcome;Participant;peer;Performance;Phase;Physical activity;Population Study;Positioning Attribute;Postdoctoral Fellow;Prevention;primary outcome;Public Health;Recommendation;recruit;Research;Research Personnel;Resistance;resistance exercise;response;Role;Sample Size;sedentary lifestyle;sex;Skeletal Muscle;sociodemographics;Somatotype;Surveys;Testing;Time;Tissues;tool;Training;Training Activity;Training Programs;trend;Underrepresented Minority;Universities;Video Recording

PROJECT_TITLE: Developing, Validating, and Implementing an Epidemiological Instrument to Assess the Effect of Resistance Training on Measures of Cardiometabolic Disease


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Although teen dating violence (TDV) is a major public health problem with serious consequences, we and others have shown that it can be prevented. The current study will test whether the seventh-grade version of an evidence-based TDV prevention program (Fourth R) is effective in the long-term reduction of the perpetration and victimization of physical, psychological, and sexual TDV. The study will also test whether a text-based booster session administered five years after the intervention will enhance the long-term effectiveness of Fourth R in reducing TDV.

PI_NAMEs: TEMPLE, JEFF R (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: 21 year old;Address;Adolescence;Adolescent;Adult;Affect;Age;American;Attitude;Behavior;Behavioral;Cognitive;Communication;condoms;conflict resolution;Control Groups;cost;Cost Analysis;cost-effectiveness evaluation;Costs and Benefits;Data;Data Collection;dating violence;dating violence prevention;Development;Dose;early adolescence;Economic Burden;Educational Curriculum;Effectiveness;emerging adult;emerging adulthood;emotional abuse;Environmental Risk Factor;evidence base;Evidence based program;experience;Financial Hardship;Health;high risk sexual behavior;high school;improved;indexing;Intervention;intimate partner violence;junior high school;long term COVID-19 pandemic impacts;Mental Depression;Mental Health;Neighborhoods;Occupations;Outcome;Participant;partner violence;Pattern;peer;Performance;perpetrators;Personal Satisfaction;physical abuse;Population;post intervention;Post-Traumatic Stress Disorders;Prevalence;prevent;Prevention approach;prevention evaluation;Prevention program;Prevention strategy;Problem Solving;programs;Psyche structure;psychologic;psychological symptom;Public Health;Randomized;Randomized, Controlled Trials;Research;Resistance;Resources;Risk;Risk Behaviors;Schools;seventh grade;Sexual abuse;skills;social;Students;Subgroup;substance misuse;substance use;suicidal;Teen Dating Violence;Teenagers;Testing;Text;Text Messaging;Time;Victimization;violence perpetration;Well in self;young adult

PROJECT_TITLE: Long-term effectiveness of a middle school dating violence prevention evaluation with and without an SMS booster

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BREGA, ANGELA GWEN (contact)

PROJECT_TERMS: 19 year old;20 year old;Address;Adherence;Adoption;Affect;Age;Alaska Native;American;American Indians;Area;Attention;base;Blood Pressure;Budgets;care costs;Caring;Cause of Death;Cessation of life;Cholesterol;Clinical;Collaborations;Colorado;Communities;community engagement;Community Outreach;community setting;Congresses;Consultations;Development;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;Diagnosis;Diffusion;disease classification;Disparity;dissemination science;Effectiveness;End stage renal failure;ethnic minority;ethnic minority population;Evaluation;evidence base;Evidence based practice;Faculty;falls;Funding;General Population;Glycosylated hemoglobin A;Goals;Health;health disparity;health information technology;health literacy;Healthcare Systems;Heart Diseases;implementation science;improved;Incidence;Individual;innovation;Intervention;Knowledge;limb amputation;Lower Extremity;Measurement;Medical;Methods;Mission;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Native-Born;Nature;Non-Insulin-Dependent Diabetes Mellitus;Outcome;participant retention;Patient Recruitments;Patients;Persons;Policies;Population;premature;Premature Mortality;Prevalence;Prevention;programs;Provider;Qualitative Research;Race;racial minority;racial minority population;Recommendation;Research;Research Methodology;Research Personnel;Resources;response;Risk Factors;Rural Population;Satellite Centers;Services;Sister;Structure;Training;Translating;Translational Research;Translations;treatment program;United States Indian Health Service;Universities

PROJECT_TITLE: Translational Research Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Despite well-intentioned efforts, there has been a decline in the numbers of researchers in neurological disorders from ethnic and racial groups historically underrepresented in science. The goal of this project is to develop an innovative longitudinal approach to recruiting and retaining talented underrepresented individuals among graduate students, postdoctoral fellows and early stage investigators. This program will ultimately create a sustaining network of researchers contributing to increased diversity and novelty of thought to solve the human problem of neurological disease.

PI_NAMEs: MEISEL, ROBERT L (contact);MERMELSTEIN, PAUL G

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Address;Brain;career;cohort;Communities;Country;Data Reporting;Depressed mood;design;Development;Discipline;Education Projects;Educational process of instructing;Educational workshop;Elements;Ensure;Ethnic Origin;Ethnic Population;Event;experience;Exposure to;Face;Faculty;Failure;falls;Generations;Goals;graduate school;graduate student;Human;Individual;innovation;Laboratories;Learning;medical schools;meetings;member;Mentors;Mentorship;Methods;Minnesota;minority investigator;Modernization;Nervous System Disorder;Neurosciences;novel;Participant;Patient Self-Report;peer;Peer Group;post-doctoral training;Postdoctoral Fellow;Program Development;Program Sustainability;programs;Publishing;Race;racial population;recruit;Reporting;Research;Research Personnel;Resources;Route;Science;Scientist;Site;skills;social;Societies;Structure;Study Section;success;support network;System;Talents;Teleconferences;Time;Training;Training Programs;Underrepresented Students;Universities;Work

PROJECT_TITLE: A Longitudinal Mentoring Approach to Increase Diversity Among Researchers of Neurological Disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Digestive Diseases;Neurosciences;Opioids;Pain Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Abdominal pain is one of major symptoms in patients with irritable bowel syndrome (IBS) and 40% of these patients with moderate to severe abdominal pain take opioids. A novel noninvasive electrical stimulation method delivered to some special body points is proposed in this project for the treatment of pain in patients with IBS.

PI_NAMEs: CHEN, JIANDE  (contact)

PROGRAM_OFFICER_NAME: HUDAK, ERIC MICHAEL

PROJECT_TERMS: Abdominal Pain;Acupuncture Points;Acupuncture Therapy;Acustimulation;Acute;Adult;Affect;Analgesics;Animal Model;Basic Science;care seeking;chronic abdominal pain;Clinical;Clinical Data;Clinical Research;Clinical Trials;cloud platform;Collaborations;computerized;Constipation;cost;Country;Data;data mining;design;Development;Device or Instrument Development;Devices;Diarrhea;Electric Stimulation;Electroacupuncture;Electrodes;Esthesia;Future;Gastrointestinal Diseases;Gastroparesis;Grant;Healthcare;Heroin;Home;Hospitals;Hypersensitivity;Impairment;improved;Irritable Bowel Syndrome;Location;Medical;Medical center;Methodology;Methods;Morphine;Narcotics;Nausea;Needles;Neuromodulator;neuroregulation;novel;novel therapeutics;Opioid;opioid epidemic;opioid use;Outcome;Pain;Pain management;pain score;Patient Compliance;patient health information;patient population;patient subsets;Patients;Peripheral Nerves;pharmacologic;Phase;Physicians;Physiological;Population;pressure;primary outcome;Randomized;Recording of previous events;recruit;Rectum;Regulatory Affairs;remote monitoring;research study;side effect;smartphone application;success;Surface;Symptoms;Testing;Therapeutic;therapy adherence;therapy outcome;Time;transmission process;Treatment Efficacy;Treatment outcome;Treatment Protocols;United States National Institutes of Health;Visceral;Visceral pain;Vomiting;wearable device;Work

PROJECT_TITLE: Home-based transcutaneous electrical acustimulation for abdominal pain


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: FORT, MEREDITH PARRISH (contact)

PROJECT_TERMS: Address;Administrator;Advocacy;Advocate;Affect;Alaska Native;American Indians;Behavioral;behavioral health;care providers;Caring;clinical practice;Collaborations;Colorado;Communication;Communities;community engaged research;community engagement;Community Health;Community Outreach;community setting;Congresses;Consumption;Creativeness;Dedications;Development;diabetes education;Diabetes Mellitus;Diabetes prevention;Diagnosis;Diffusion;Doctor of Philosophy;Economics;Ensure;Evaluation;evidence base;Evidence based practice;experience;Feasibility Studies;Goals;Health;Health Professional;Health Services;Healthcare;Healthcare Systems;Hypertension;hypertension prevention;Immersion;implementation science;improved;Infrastructure;innovation;Institution;instructor;interest;Internal Medicine;Intervention;knowledge of results;learning network;medical schools;medication compliance;member;Methods;Modeling;Modernization;Native-Born;Nature;nutrition;Patients;Pilot Projects;Policies;Policy Maker;Populations at Risk;prevent;Prevention;Primary Care;Privatization;Process;professor;programs;Provider;Public Health;Reduce health disparities;Reporting;Research;Research Assistant;Research Personnel;Resources;Scientist;social;Sociology;Source;sustained attention;System;Technology;Translating;translational framework;Translational Research;Translations;tribal community;Tribes;United States Indian Health Service;Universities;urban Native American;Vision;Work

PROJECT_TITLE: Community Outreach and Engagement Core


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Maternal genes have important effects on offspring development, but few studies to date have identified how variation in these maternal genetic loci alter regulatory processes and shape developmental outcomes. This project uses a unique model system to understand how genetic interactions between maternal background and offspring genotype influence embryogenesis and ontogeny. Maternal genetic effects impact development in humans through gene-by-gene and gene-by-environment epistasis, and this project contributes to our understanding of how these processes affect human health and development.

PI_NAMEs: ZAKAS, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Architecture;Biological Models;Candidate Disease Gene;Chromosome Mapping;comparative;Databases;Development;dimorphism;egg;Embryo;embryo stage 2;Embryonic Development;Environment;Evolution;fitness;Future;Gene Expression;Genes;Genetic;genetic architecture;Genetic Epistasis;Genome;genome annotation;genomic data;genomic locus;genomic tools;Genomics;Genotype;Growth;Health;Heritability;Human;life history;Methods;Modeling;Molecular;novel;offspring;Oocytes;Organism;Outcome;Phenotype;Population;Process;programs;Research;Role;Shapes;Technology;transcriptome;transcriptomics;Variant

PROJECT_TITLE: Maternal Genetic Effects Shape Developmental Evolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP)  Overall Component: Narrative This proposed P20 partnership will contribute to the enhancement of cancer health equity research in Orange County, California through the development of institutional capacities, support of meritorious joint cancer research pilot projects, and the provision of cancer research experiences and programs for underrepresented students. The long term goal is to increase the diversity of the cancer research workforce at both partnering institutions, and increase the number of investigators conducting cancer health equity research.

PI_NAMEs: TANJASIRI, SORA P (contact)

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Address;Administrator;Advisory Committees;Advocate;African American;anti-cancer research;Applications Grants;Asian;Basic Science;Biological Sciences;Biotechnology;Breast Cancer Risk Factor;California;Cancer Center;cancer health disparity;Cancer health equity;cancer research center director;Collaborations;Communities;community engagement;community research;Comprehensive Cancer Center;County;Data;Development;disability;DNA sequencing;Education;Education and Outreach;education research;Educational Curriculum;Environment;Epidemiology;epidemiology study;ethnic diversity;Ethnic Population;Evaluation;experience;Faculty;Family;Fostering;Funding;Future;Genetic;Genomics;Goals;graduate student;Grant;Health Disparities Research;Health equity research;improved;innovation;Institution;institutional capacity;Institutionalization;Joints;Knowledge;Length;Lesbian Gay Bisexual Transgender Queer;lipidomics;Low income;Malignant neoplasm of ovary;Malignant Neoplasms;meetings;member;minority health;minority health disparity;mortality;Oranges;outreach;Pilot Projects;Population;Preparation;Principal Investigator;professor;programs;Recommendation;Records;Research;Research Personnel;Research Project Grants;Research Training;Sampling;Scientist;Seasons;student training;Students;System;Talents;Teacher Professional Development;Training;Training Activity;Training and Education;Training Programs;transcriptome sequencing;transcriptomics;treatment pattern;triple-negative invasive breast carcinoma;tumor;undergraduate student;underrepresented minority student;Underrepresented Students;Underserved Population;United States National Institutes of Health;Universities

PROJECT_TITLE: 2/2 CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP)


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;anti-cancer research;Applications Grants;Asian Americans;Basic Science;Benchmarking;Biological Sciences;Biotechnology;California;Cancer Center;Cancer Control;cancer health disparity;Cancer health equity;cancer prevention;Cancer Research Project;Catchment Area;Clinical Sciences;Collaborations;Communication;Communities;community based participatory research;community engagement;Comprehensive Cancer Center;Decision Making;design;Doctor of Philosophy;Education;education research;Educational Curriculum;Ensure;Epidemiology;ethnic diversity;Evaluation;experience;Family;Funding;Future;Geographic Locations;Goals;graduate student;Grant;Health Disparities Research;Health equity research;Hispanic;improved;Institution;Institutionalization;International;Knowledge;Leadership;Learning;Los Angeles;Minority;Molecular Genetics;Monitor;Native Americans;Office of Administrative Management;organizational structure;Outcome;Pacific Island Americans;Pacific Islander;pathogenic bacteria;Population Heterogeneity;Population Sciences;Principal Investigator;Process;professor;programs;Recommendation;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Training;Resources;Scientist;Structure;Student recruitment;Students;success;System;Talents;Training;Training and Education;Training Programs;Translational Research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities;Virulence


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

PHR: Project Narrative  Glycans, complex carbohydrates that bind to proteins, are regularly analyzed by electrospray ionization (ESI) – mass spectrometry (MS). The goal of this proposal is to provide a molecular perspective on how ESI affects the glycan and protein structures that are analyzed by MS. Ultimately, this work will enable the validation of these MS-based methods and generate new analytical methods for characterizing these molecules, which are important in cell biology, disease progression, and pathogen infection.

PI_NAMEs: GALLAGHER, ELYSSIA S (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: Address;adduct;Affect;analytical method;Binding;Biological;Biological Process;Carbohydrates;Cells;Cellular biology;Charge;Complex;deprotonation;Development;Disease;Disease Progression;Electrospray Ionization;Exhibits;Future;Gases;Glycoconjugates;Goals;host-microbe interactions;improved;Infection;insight;ion mobility;ionization;ionization technique;Ions;Isomerism;Ligand Binding;Mass Spectrum Analysis;Metals;Methodology;Methods;Modeling;Molecular;molecular dynamics;molecular recognition;novel;pathogen;Phase;Polymers;Polysaccharides;Process;Property;protein complex;protein structure;Proteins;protonation;Research;Research Personnel;Signal Transduction;Sodium;Spectrometry, Mass, Electrospray Ionization;Structure;tandem mass spectrometry;Techniques;tool;Validation;Work

PROJECT_TITLE: Assessing the Biomolecular Structures that Result from Electrospray Ionization


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: HUEBSCHMANN, AMY GROTELUESCHEN (contact)

PROJECT_TERMS: Address;Alaska Native;American Indians;Area;Aspirin;base;Blood Glucose;Blood Pressure;Body Weight decreased;cardiovascular disorder risk;care costs;Case Management;Center for Translational Science Activities;Cholesterol;Chronic;Clinical;Colorado;Communities;Complication;Congresses;Consultations;Consumption;Country;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diet;dietary;dissemination science;efficacy trial;End stage renal failure;ethnic minority population;evidence base;Evidence based practice;Exhibits;experience;Faculty;Funding;Health;health disparity;health literacy;health organization;Health system;Health Technology;Healthcare;high risk;implementation science;improved;innovation;Institution;Institutionalization;Intervention;Knowledge;Learning;Medical;medical specialties;member;multidisciplinary;Native-Born;Nature;Outcome;outcome disparities;Participant;Patients;Physical activity;Policies;Population;programs;Qualitative Research;racial minority population;Research;Research Methodology;Research Personnel;Resource Allocation;Resources;Risk Reduction;Rural;Satellite Centers;Sister;skills;smoking cessation;Structure;tool;Training;Translating;Translational Research;translational research program;treatment program;Tribes;United States Indian Health Service;Universities;urban Native American;Work

PROJECT_TITLE: National Resource Core


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: PROJECT NARRATIVE The Kentucky ECHO-Pediatric IDeA Research Center (KE-PIRC), as part of the ECHO IDeA States Pediatric Clinical Trials Network, will continue to make it possible for 1) rural and underserved infants, children and adolescents to participate in clinical research; 2) junior investigators to be trained in clinical research and community engagement, improve the health of both children and adults in Kentucky through this research, and develop their academic career; and 3) the development of a regional network of partners to sustain this clinical research initiative. The five primary focus areas are 1) pre-, peri- and postnatal outcomes; 2) neurodevelopmental; 3) upper and lower airway disease; 4) obesity; and 5) positive health. These primary focus areas are highly prevalent in Kentucky, therefore the efforts of the KE-PIRC in collaboration with our community partners will improve the health outcomes of Kentucky children and adults.

PI_NAMEs: DEVLIN-PHINNEY, LORI ANN;WATSON, SARA E (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Academic Medical Centers;Acceleration;Address;Adolescent;Adult;Airway Disease;Alcohol consumption;Appalachian Region;Area;autism spectrum disorder;biomedical referral center;care outcomes;career;Child;Child Health;Child health care;Childhood;Chronic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;cohort;Collaborations;Communication;Communities;community engagement;community partners;community partnership;Development;Diabetes Mellitus;Disease;Drug abuse;Education;Educational Status;Environment;Environmental Health;ethnic minority;Etiology;Faculty;Family;Feedback;fetal;Fetal Development;Funding;Generations;Goals;Health;Health Benefit;Healthcare;Heart Diseases;High Prevalence;improved;Individual;Infant;innovation;Institution;Intervention;Kentucky;Leadership;Malignant neoplasm of lung;member;Mentors;Mentorship;Multi-Institutional Clinical Trial;Neonatal;Neurologist;next generation;novel strategies;nutrition;Obesity;Occupational Exposure;Outcome;outreach program;Participant;patient population;Patients;Pediatric Hospitals;pediatrician;pediatrician scientist;Perinatal;Physicians;Population;Population Heterogeneity;postnatal;Preventive;Primary Care;Process;programs;Provider;racial minority;recruit;Refugees;Research;Research Infrastructure;Research Personnel;Resources;Rural;rural area;Rural Community;Rural Population;rural underserved;senior faculty;Site;skills;Smoking;Stroke;success;System;Talents;Teacher Professional Development;Time;Training;Training and Education;Underrepresented Minority;underserved area;Underserved Population;United States National Institutes of Health;Universities;Urban Community;urban underserved;Vulnerable Populations;Work

PROJECT_TITLE: The Kentucky ECHO Pediatric IDeA Research Center (KE-PIRC)


NIH_SPENDING_CATS: Cancer;Clinical Research;Social Determinants of Health

PHR: CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP)  Cancer Research Education Program (CREP): Narrative The Cancer-Related Education Program (CREP) will contribute to the enhancement of cancer health equity in Southern California. CREP will promote an increase in the diversity of the cancer research workforce by training undergraduate and master’s graduate students in cancer health disparities-related research efforts, especially those from underrepresented groups. CREP will provide cancer and cancer health disparities education to undergraduate and master’s students. CREP will also include several outreach activities at CSUF and UCI to disseminate information about the program and the importance of cancer research and cancer disparities. .

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;anti-cancer research;base;Biological;California;Cancer Burden;Cancer Center;cancer health disparity;Cancer health equity;career;career preparation;Communication;Communities;community building;Data;Degree program;Diagnosis;Education;education pathway;education research;Environment;ethnic diversity;Evaluation;experience;Face;Faculty;faculty mentor;Future;Goals;graduate student;Health Disparities Research;health disparity populations;health equality;Health equity research;Incidence;Institution;Instruction;Laboratories;Learning;Length;Malignant Neoplasms;Monitor;Morbidity - disease rate;mortality;novel;nutrition;operation;outreach;peer;Population;Population Heterogeneity;Prevalence;programs;Quality of life;recruit;Research;Research Personnel;Research Training;responsible research conduct;Scholars Program;Science;Scientist;Series;Sister;skills;Socioeconomic Factors;socioeconomics;Stress;Student Persistence;Students;success;summer research;survivorship;symposium;Talents;tool;Training;Travel;undergraduate student;underrepresented minority student;Underrepresented Populations;Underrepresented Students;Vertebral column;Work

PROJECT_TITLE: CHERP Cancer Research Education Program


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Lung;Prevention;Rare Diseases;Sepsis

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This multicenter clinical trial will examine whether the use of an antiviral drug called ganciclovir can safely and effectively prevent reactivation of a common virus called cytomegalovirus and improve clinical outcomes in adults with sepsis-associated acute respiratory failure. If this study shows a clinical benefit, routine use of this antiviral drug could become standard therapy to improve the outcomes of adults with prior exposure to CMV and who have sepsis-associated acute respiratory failure requiring mechanical ventilation.

PI_NAMEs: BOECKH, MICHAEL J (contact);LIMAYE, ABHIJIT PRAKASH;RUBENFELD, GORDON D;STAPLETON, RENEE D

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acceleration;Acute respiratory failure;Admission activity;Adult;adverse outcome;Age;Animal Model;Anti-viral Agents;Area;Caring;cell type;Clinical;clinical practice;clinical research site;Clinical Trials;clinically relevant;Collaborations;comorbidity;Critical Illness;Cytomegalovirus;Cytomegalovirus Infections;Data Analyses;Data Coordinating Center;Disease;Double-Blind Method;Enrollment;Event;experience;Exposure to;Functional disorder;Funding;Ganciclovir;Gender;Grant;Health Expenditures;Herpesviridae;Hospitalization;Hour;Human;Immunocompetent;Immunocompromised Host;improved;improved outcome;Incidence;Infrastructure;insight;Intervention;Intervention Studies;Investigation;Kinetics;Length of Stay;Lung;lung injury;Lymphocyte Count;Measures;Mechanical ventilation;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;Nature;Observational Study;Organ;Outcome;Patient Care;Patient Recruitments;Patient-Focused Outcomes;Patients;Persons;pharmacologic;Phase;Plasma;Population;Positioning Attribute;Predictive Factor;prevent;Prevention;Prophylactic treatment;Publishing;Race;Randomized;randomized placebo controlled trial;Recovery;Research;Research Design;Respiratory Failure;Respiratory System;Safety;secondary outcome;Sepsis;seropositive;Severity of illness;Site;Survivors;Testing;Time;trend;Ventilator;Viral Load result;virology;Virus;Virus Replication

PROJECT_TITLE: 1/2 Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients with Acute Respiratory Failure and Sepsis

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(JA)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Racial and Ethnic Minority Health Research;Rural Health

PROJECT_TERMS: Address;Aging;Alaska Native;Alaska Native population;American Indian Population;American Indians;Applications Grants;Area;base;Breast Feeding;burden of illness;career;Cementation;Clinical Treatment;Collaborations;Colorado;Communities;community based research;community engaged approach;community organizations;community setting;Coronary heart disease;Data;data collection evaluation;Development;Diabetes Mellitus;Education;Environment;Evidence based intervention;Evidence based treatment;experience;food insecurity;Funding;Goals;Government;Grant;Health;health care settings;health inequalities;improved;Inequity;innovation;Intervention;Investments;Knowledge;life span;Linguistics;Medical;meetings;member;Mentorship;Methodology;Minority;Mission;Morbidity - disease rate;Not Hispanic or Latino;Obesity;Outcome;Pattern;Pilot Projects;Play;Policies;Population;Prevention;Principal Investigator;programs;Publications;Publishing;Qualifying;Relationship-Building;Research;Research Activity;Research Personnel;Research Training;Resources;Role;Satellite Centers;Science;secondary analysis;skills;Source;success;Targeted Research;Training;Training Programs;Translational Research;Translations;Tribes;United States National Institutes of Health;Universities;Variant;Woman;Work;Writing

PROJECT_TITLE: Pilot & Feasibility Core


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Project Narrative Obesity and its metabolic sequelae place severe medical and economic burdens on the United States, and adipose tissue plays a central role in these pathologies. The proposed research aims to understand the cellular compositions and cell-to-cell interactions of thermogenic adipose tissue. The results will improve our knowledge of the regulation of thermogenic metabolism and may ultimately lead to new therapeutic approaches for the treatment and prevention of obesity and metabolic diabetes.

PI_NAMEs: TSENG, YU-HUA  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;adipocyte differentiation;Adipocytes;adipose derived stem cell;Adipose tissue;Adult;Afferent Neurons;Agonist;Animals;Anterior;Biopsy;Brown Fat;Calcium;Capsaicin;Cardiometabolic Disease;Cardiovascular Diseases;Cations;Cell Communication;cell type;Cells;Cervical;Coculture Techniques;Complex;computerized tools;Conditioned Culture Media;Data;Databases;Development;Diabetes Mellitus;Economic Burden;Energy Metabolism;Etiology;Fatty acid glycerol esters;Flow Cytometry;Functional disorder;gain of function;Genes;Health;Heterogeneity;House mice;Human;Image;Impairment;improved;In Vitro;Individual;insight;intercellular communication;Ion Channel;Knowledge;Ligands;Link;lipid biosynthesis;loss of function;Low Prevalence;Maps;Measures;Medical;member;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Methods;Modeling;mouse model;Mus;Neck;Nociception;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;obesity prevention;optogenetics;Outcome;Pathology;Physiologic Thermoregulation;Physiological;Platelet-Derived Growth Factor alpha Receptor;Play;Population;PPAR gamma;progenitor;Proliferating;receptor;Receptor Signaling;Regulation;release of sequestered calcium ion into cytoplasm;Research;response;Rodent;Role;Scheme;Shapes;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;stem cells;Stimulus;System;Temperature;Testing;Therapeutic;transcriptome;transcriptomics;Triglycerides;TRP channel;United States;Vascular Smooth Muscle;volunteer

PROJECT_TITLE: Dissecting the thermogenic adipose niche

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: STOTZ, SARAH A (contact)

PROJECT_TERMS: Acute;Administrator;Alaska Native;American Indians;aspirate;Attention;Awareness;base;Collaborations;Colorado;Communities;Community Healthcare;density;design;Diabetes Mellitus;Diabetes prevention;Ensure;Evaluation;Evidence based practice;expectation;experience;Faculty;Faculty Recruitment;Funding;Health;health care service organization;Home;innovation;insight;Institution;Institutionalization;interest;Knowledge;Learning;lectures;lens;Life;Medical;meetings;member;Outcome;outreach;Participant;Patients;Population;Positioning Attribute;prevent;programs;Progress Reports;Provider;Recruitment Activity;Research;Research Personnel;Resources;response;Satellite Centers;Schools;Science;Scientific Advances and Accomplishments;Scientist;Series;skills;Social Network;Strategic Planning;symposium;Training;Translational Research;tribal community;Tribes;United States Indian Health Service;Universities;webinar;Work

PROJECT_TITLE: Enrichment Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Pediatric

PHR: NARRATIVE Pathways to Cancer Research Renewal attracts underrepresented and economically disadvantaged students to science, inspires them to pursue research careers, and supports them as they advance professionally. Increasing diversity among researchers brings new perspectives that stimulate innovation and that ensures future cancer researchers will represent the communities they serve, including populations disproportionately impacted by cancer. This renewal has a special emphasis on two areas of need identified by the NCI: the role of computational biology in current and future research and the importance of working with communities to address health inequities.

PI_NAMEs: CHOWNING, JEANNE TING (contact);VANNIER, DAVID M

PROGRAM_OFFICER_NAME: CALZOLA, JESSICA MARIE

PROJECT_TERMS: Address;anti-cancer research;Area;Award;broadening participation research;Cancer Education Grant Program;cancer health disparity;career;career awareness;Code;Collaborations;Communication;Communities;Community Actions;Computational Biology;Computer Analysis;computerized tools;Computing Methodologies;Data Set;Dedications;design;Development;disadvantaged student;E-learning;economic disparity;Education Projects;Educational Curriculum;Educational process of instructing;Eligibility Determination;Emotional;Ensure;Event;experience;Faculty;Family;Fellowship;Fostering;Fred Hutchinson Cancer Research Center;Future;Goals;health inequalities;high school;high school program;High School Student;holistic approach;Home;innovation;Institution;interest;Internships;Investments;Knowledge;Malignant Neoplasms;Mentors;National Cancer Institute;outreach;outreach program;pandemic disease;Pathway interactions;Population;programs;Recording of previous events;Research;Research Personnel;response;Role;Schools;Science;science education;science teacher;Scientist;Site;social;STEM career;Structure;student training;Students;teacher;Testing;twelfth grade;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;virtual;virtual internship;Washington;Work;Youth

PROJECT_TITLE: Pathways to Cancer Research Renewal

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Adiponectin has morphed into a widely-used biomarker reflecting the health of adipose tissue and systemic insulin sensitivity. Understanding the cellular and systemic physiology of adiponectin and its receptors has proven invaluable for a better understanding of the role of the adipocyte in systemic metabolic homeostasis. The experiments outlined here will not only focus on novel adiponectin fragments that act inside the cell, but will also focus on the role of adiponectin in non-adipocytes, particularly the cells of the proximal tubules in the kidney and in hepatic stellate cells.

PI_NAMEs: SCHERER, PHILIPP E (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acute;Address;Adipocytes;adipokines;adiponectin;Adipose tissue;Anti-Inflammatory Agents;Apoptotic;Area;Biological Markers;Biological Models;Biological Process;Cardiac Myocytes;Cell Fractionation;Cell Nucleus;Cells;Ceramides;Clinical;Communication;Confusion;Cytoplasm;Data;Distal;Embryo;Endocrine Glands;Exons;experimental study;extracellular vesicles;Funding;gain of function;Genes;genetic manipulation;Genetic Transcription;Gluconeogenesis;Grant;Health;Heart;Hepatic Stellate Cell;Hepatocyte;Homeostasis;insight;Insulin;insulin mediators;insulin sensitivity;Kidney;kidney cell;kidney cortex;Knock-out;knockout animal;Knockout Mice;Knowledge;Learning;Leptin;Lipids;Location;loss of function;LoxP-flanked allele;mature animal;Mediator;Metabolic;metabolic abnormality assessment;metabolic phenotype;Modeling;mouse model;Mus;Myofibroblast;Nature;novel;Nuclear;Organ;overexpression;Pathway interactions;Phenotype;Physiology;Play;Positioning Attribute;pre-clinical;prevent;Process;Production;Property;Protein Secretion;Proteins;Proximal Kidney Tubules;Publications;receptor;receptor expression;Regulation;Role;Secretory Cell;Signal Transduction;Site;Sphingolipids;stellate cell;temporal measurement;Testing;Time;Tissues;Untranslated RNA;vesicular release;Work

PROJECT_TITLE: Adiponectin, A Protein Secreted From Adipose Tissue

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Diabetes;Genetics;Nutrition;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The role of the pancreatic b-cell is to secrete insulin in response to glucose. Defects in this process can result in inadequate insulin secretion causing diabetes or excessive insulin secretion causing hyperinsulinism. The goal of this project is to understand how the same mutations in the transcription factor HNF1a can cause both of these opposing diseases through disruption at different points along the insulin secretion cascade.

PI_NAMEs: LEAVENS, KARLA FITZGERALD (contact)

PROJECT_TERMS: Acute;Advisory Committees;Age;Amino Acids;Applications Grants;Area;Automobile Driving;B-Lymphocytes;Basic Science;Beta Cell;Biological Models;Candidate Disease Gene;career development;Cell Maturation;Cell model;Cells;Clinical;Communities;Complex;Coupled;Data;Defect;Development Plans;Diabetes Mellitus;directed differentiation;Disease;Dissociation;Down-Regulation;drug action;Educational workshop;energy balance;Environment;Exhibits;experimental study;Foundations;Functional disorder;Future;Gene Mutation;Generations;Genes;genome editing;Glucose;glucose metabolism;Glycolysis;Goals;Heterozygote;Human;human stem cell-derived;Hyperinsulinism;Individual;Insulin;Insulin deficiency;insulin secretion;Knowledge;knowledge base;Learning;Link;loss of function;loss of function mutation;Measures;Mediator;medical schools;Mendelian disorder;Mentors;Metabolic;Metabolism;Methods;Modeling;Mus;mutant;Mutation;NADH;NADP;novel;Nutrient;Pathogenesis;Pathway interactions;Patients;Pediatric Hospitals;Pennsylvania;Persistent Hyperinsulinemia Hypoglycemia of Infancy;Phase;Philadelphia;Process;Production;Publications;Publishing;Regulation;Research;response;RNA Interference;Role;Signal Pathway;skills;stem cells;Structure of beta Cell of islet;Techniques;Testing;Training;transcription factor;Translational Research;transplant model;type I and type II diabetes;Universities;Work;Xenograft procedure

PROJECT_TITLE: Dissecting the mechanisms behind biphasic beta cell disease caused by mutations in HNF1alpha

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PI_NAMEs: NAGHIZADEH SAFA, BABAK  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Acute;Address;Adrenergic Agents;Affect;Age;Anatomy;Animal Model;Animals;Anterior;anterior chamber;Anti-Cholinergics;Aqueous Humor;Basic Science;biomechanical test;Biomechanics;Blindness;Cadaver;career;Cholinergic Agents;Clinical;Clinical Research;clinical risk;Clinical Trials;comparison control;Computer Models;constriction;Data;Development;Dilator;Disparity;Elements;Engineering;Evaluation;Eye;Female;Functional disorder;Future;Glaucoma;high risk;Histology;Human;human subject;Hybrids;Image;improved;in vivo;in vivo evaluation;Individual;Iris;Learning;lens induction;Light;Link;male;Measures;Mechanics;medically necessary care;Mentors;Modeling;Morbidity - disease rate;Muscle;Muscle Contraction;Mydriasis;Oryctolagus cuniculus;Outcome;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;Physiologic Intraocular Pressure;Physiological;Play;pressure;Prevalence;prevent;Primary Angle Closure Glaucoma;Property;Protocols documentation;Public Health;Pupil light reflex;Race;Recording of previous events;Relaxation;Research Personnel;Risk;Risk Factors;risk stratification;Role;sex;Sex Differences;skills;Sphincter;Study Subject;Techniques;Testing;therapeutic target;Tissues;Traction;Training;Validation;Woman;Women's prevalence

PROJECT_TITLE: The role of iris biomechanics and sex differences in primary angle-closure glaucoma


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative The proposed R36 application seeks to examine how police officers in Baltimore City, Maryland, are responding to drug policy reforms and the broader cultural shift away from punitive responses to substance abuse that are associated with negative health outcomes for people who use drugs (PWUD) in favor of evidence-based public health approaches rooted in harm reduction. Through in-depth interviews with 20 senior officers of the Baltimore Police Department (BPD), observation of 15 public-facing BPD events, and 60 observations of street-level officers in the form of ride-alongs with patrol and detective units, this research will qualitatively explore the way BPD leadership integrate harm reduction approaches to drug enforcement into the department’s organizational approach toward PWUD, and street-level officers’ beliefs, attitudes, and enforcement practices towards PWUD. Findings will inform ongoing debates over drug policy and the role of law enforcement in harm reduction, as well as identify barriers and avenues for widespread and enduring police reform that facilitates police enforcement practices that are in alignment with, not antithetical to, public health.

PI_NAMEs: SILBERZAHN, BRADLEY EDWARD (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Acceleration;Adopted;Appearance;Area;Attention;Attitude;authority;Baltimore;Belief;Cessation of life;Cities;Collaborations;Communities;Criminal Justice;Data Collection;Development;Disease;Diversion Program;Drug usage;Drug user;Environment;Epidemic;Evaluation;Event;evidence base;Exclusion;experience;Faculty;Fellowship;first responder;Fright;Harm Reduction;Health;health care service;Health system;HIV/STD;illicit drug use;insight;Institution;Intervention;Interview;Investigation;Justice;Law Enforcement;Lead;Leadership;Legal;Legitimacy;maltreatment;marginalized population;Maryland;Measures;Mediation;Naloxone;New York;Organizational Change;Outcome;Overdose;overdose risk;Pharmaceutical Preparations;Play;Police;Police officer;Policies;Prevention;Principal Investigator;Procedures;Program Evaluation;programs;Public Health;Public Health Schools;Race;racial disparity;Recording of previous events;Research;Research Personnel;response;Risk;Role;Safety;Schools;service providers;Services;Shapes;sociodemographics;Sociology;Stress;structural health determinants;Substance abuse problem;substance use;success;Syringes;System;Texas;theories;Transcript;Translating;Universities;Violence

PROJECT_TITLE: Harm Reduction Policing? A Qualitative Study of Police Culture and Enforcement Practices Toward People Who Use Drugs Amidst Efforts to Align Public Health and Public Safety Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)]