NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PI_NAMEs: LI, XIUFENG  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: Address;Adipocytes;Adolescent;Adult;Affect;Algorithms;arterial spin labeling;Blood;Blood capillaries;Blood flow;bone;Bone Development;Bone Marrow;bone repair;Brain;Clinical;Clinical Research;cohort;Communities;Degenerative polyarthritis;design;Development;Diagnostic;Disease;Disease Progression;Echo-Planar Imaging;Etiology;experience;Family;Functional disorder;Goals;healing;Healthcare;human model;Image;imaging modality;imaging platform;imaging study;improved;insight;Knee;Knowledge;Lesion;Libraries;Logistic Regressions;magnetic field;Magnetic Resonance Imaging;Measures;Methodology;Methods;Modeling;Monitor;new technology;next generation;Noise;Nomograms;novel;Osteochondritis Dissecans;Patients;Performance;Perfusion;Physiologic pulse;Physiological;Physiology;Play;Population;prognostic performance;Research;research study;response;RF coil;ROC Curve;Role;Safety;safety assessment;Signal Transduction;skeletal disorder;Slice;software systems;Speed;System;Technology;Therapy Evaluation;Time;Tissue Viability;Tissues;tool;transmission process;treatment response;Uncertainty;virtual;virtual model

PROJECT_TITLE: Advanced Knee ASL Imaging at 7T

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Skin Cancer;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: ONEGA, TRACY  (contact)

PROJECT_TERMS: Address;Adherence;Adolescent;Appointment;Area;Basic Science;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Etiology;Cancer health equity;Cancer Patient;cancer risk;Caring;Catchment Area;Cause of Death;Cessation of life;Charge;Childhood;Clinical Research;Clinical Trials;Colorectal Cancer;Communities;community advisory board;community based service;community engaged approach;community engaged research;community engagement;community organizations;Community Outreach;community partners;Data;Dedications;demographics;Disparity population;Doctor of Philosophy;Education;Education and Outreach;Equity;Family;Federally Qualified Health Center;Fostering;frontier;gene discovery;Geography;Goals;Grant;Guidelines;Health;health disparity;health equity;Health equity research;Healthcare Systems;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Idaho;implementation research;improved;Incidence;individualized prevention;Inherited;innovation;Investments;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Melanoma;member;Monitor;Montana;mortality;Names;National Cancer Institute;Nevada;Oncogenes;Outcome;outreach;patient population;Patients;Policies;Population;population health;Prevention;Prevention education;Process;programs;Radon;Recommendation;Research;Research Personnel;Resolution;Risk Behaviors;Rural;Science;Services;Strategic Planning;sun safety;Targeted Research;tobacco control;Translating;Utah;Work;Wyoming

PROJECT_TITLE: Community Outreach and Engagement

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The goal of modern oligosaccharide synthesis is the efficient production of natural and unnatural oligosaccharides, and their mimetics, capable of interfering constructively in disease states. This interference may be brought about by the blocking of oligosaccharide processing enzymes, by disruption of bacterial cell wall biosynthesis, by modulating cell-cell recognition, by enhancing binding and selectivity of drugs to DNA, and by the provision of antigenic oligosaccharides in synthetic vaccines. All of these processes require the highly efficient synthesis of oligosaccharides. The goal of this project is to provide a deeper understanding of glycosylation reaction mechanism, and to apply that understanding to i) the design of new and improved methods for the synthesis of biologically-relevant glycosidic bonds, and ii) the design of improved glycosidase and glycosyl transferases inhibitors.

PI_NAMEs: CRICH, DAVID  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Methods and Mechanisms in Carbohydrate Chemistry

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: ULRICH, CORNELIA M (contact)

PROJECT_TERMS: anti-cancer research;Area;Award;Biological Markers;Biomedical Research;Budgets;burden of illness;Cancer Center;Cancer Center Support Grant;Cancer Family;Cancer Intervention;Child;Clinical;Collaborations;Core Facility;cost;Dedications;Development;Development Plans;Disease;disease model;Doctor of Philosophy;empowerment;Epidemiology;Equilibrium;Evaluation;experience;experimental study;Faculty;Faculty Recruitment;Family;Funding;Future Generations;Genetic;genetic epidemiology;Genetic Research;Genetically Engineered Mouse;Gifts;Goals;Grant;Hospitals;Institution;interdisciplinary collaboration;interest;investigator-initiated trial;Investments;Laboratories;Malignant Neoplasms;medical specialties;Mentors;Mission;Modeling;Molecular Epidemiology;mouse model;NCI Center for Cancer Research;neoplasm registry;novel;Organoids;patient derived xenograft model;Play;Population Database;Population Sciences;Pre-Clinical Model;pre-clinical research;Productivity;programs;recruit;Research;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Resource Sharing;Resources;Science;Secure;Selection for Treatments;Source;Strategic Planning;success;Talents;translational goal;Translational Research;Universities;Utah;Wages;Work

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: Fragile X is the most common genetic cause of intellectual disability and autism. Herein, we will examine the link between altered signaling pathway activity and robust deficits in mitochondrial pathophysiology in a Fragile X animal model and in patient derived cells. The goal of these studies is to determine if the mitochondrial and associated metabolic phenotypes displayed by the Fragile X models are due to established signaling pathway defects that are known to underlie the behavioral and cognitive phenotypes displayed by the Fragile X animal models and are ameliorated by treatments being used in ongoing clinical trials.

PI_NAMEs: JONGENS, THOMAS A (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Adult;aged;Animal Model;autism spectrum disorder;Behavior;Behavioral;behavioral impairment;behavioral phenotyping;Biguanides;Biochemical;Brain;Case Study;cell type;Cells;circadian;Clinical;Clinical assessments;Clinical Trials;clinically relevant;cofactor;Cognition;Cognitive;Cyclic AMP;Data;Defect;Development;dFMR1 gene;Drosophila genus;experimental study;Fibroblasts;fly;FMR1 gene;Fragile X Syndrome;Functional disorder;gene function;Genetic;Goals;Homologous Gene;Human;Impaired cognition;Impairment;improved;inhibitor;Insulin;insulin signaling;Intellectual functioning disability;Life;Link;loss of function;loss of function mutation;Memory;Memory impairment;metabolic phenotype;Metformin;Mitochondria;mitochondrial dysfunction;Modeling;mouse model;Mus;mutant;neural;Neurodevelopmental Disorder;novel;null mutation;Outcome;Output;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Periodicity;PGC1a Regulation Pathway;pharmacologic;Phase II Clinical Trials;Phenocopy;Phenotype;Physiological;PIK3CG gene;potential biomarker;Pre-Clinical Model;Reporting;restoration;Role;Signal Pathway;Signal Transduction;skills;social;spatiotemporal;Stimulation of Cell Proliferation;Symptoms;System;Testing;theories;treatment optimization;treatment strategy;Work

PROJECT_TITLE: Mitochondrial dysfunction in Fragile X: Mechanisms and treatments

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


PROJECT_TERMS: Address;Area;Basic Science;Cancer Center;Cancer Center Support Grant;Cancer Hospital;cancer prevention;cancer research center director;Capital;Catchment Area;Clinical;clinical care;Clinical Research;Clinical Sciences;college;Communities;community advisory board;Comprehensive Cancer Center;Coordination and Collaboration;Decision Making;Detection;Development;Doctor of Philosophy;Education;Education and Outreach;Effectiveness;Ensure;Evaluation;experience;Feedback;Funding;Future;Goals;Grant;Growth;Home;Huntsman Cancer Institute at the University of Utah;improved;Individual;insight;Institution;Leadership;Malignant Neoplasms;medical schools;Mission;multidisciplinary;organizational structure;outreach program;Patients;Population Sciences;Positioning Attribute;Principal Investigator;Process;programs;Research;Research Activity;Resource Sharing;Resources;response;Schools;Self-reflection;Site Visit;Source;Strategic Planning;Structure;Talents;Time;Translational Research;Universities;Utah;Vision

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

PI_NAMEs: WERNER, THERESA LOUISE (contact)

PROJECT_TERMS: Achievement;Adherence;Adolescent and Young Adult;Area;Awareness;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Patient;cancer prevention;cancer therapy;Caring;Catchment Area;Categories;Charge;Child;Cities;Clinic;Clinical;Clinical Data;Clinical Protocols;Clinical Research;clinical trial participant;Clinical Trials;Collaborations;Communities;community clinic;comparative trial;Complex;Comprehensive Cancer Center;cost;Data;data integrity;data management;Dedications;demographics;Disadvantaged;Disease;Disparity population;Doctor of Philosophy;Dose;effectiveness trial;efficacy study;efficacy trial;Ensure;Equity;ethnic minority;Ethnic Origin;experience;falls;frontier;Gender;gender minority;geographic disparity;Goals;Guidelines;health disparity;Healthcare;Home;Hospitals;improved;Infrastructure;innovation;Intervention;Intervention Trial;Investigational Therapies;Leadership;low socioeconomic status;Malignant Neoplasms;medical specialties;member;Minority;Mission;Monitor;National Cancer Institute;Outcome;patient population;patient safety;Patients;Pediatric Hospitals;Pediatric Oncology Group;Pediatric Research;Persons;Phase;Physiological;Population;Population Sciences;Practice Guidelines;Principal Investigator;Process;programs;Protocols documentation;Race;racial minority;Rare Diseases;Regulation;Reporting;Research;research faculty;Research Institute;Research Personnel;Resource Sharing;Risk;Role;Running;Rural;Safety;Socioeconomic Status;Sodium Chloride;Talents;Toxic effect;treatment choice;treatment trial;Underrepresented Minority;Underrepresented Populations;underserved minority;Underserved Population;United States;United States Department of Veterans Affairs;Utah;Woman

PROJECT_TITLE: Clinical Protocol and Data Management


PI_NAMEs: AKERLEY, WALLACE LOVELL (contact)

PROJECT_TERMS: Area;Attention;authority;Basic Science;biomedical referral center;Biometry;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Intervention;Cancer Patient;cancer therapy;Catchment Area;Clinical;Clinical assessments;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Committee Membership;Concept Review;data management;Detection;Disease;Ensure;expectation;Faculty;Goals;Hematology;Huntsman Cancer Institute at the University of Utah;Idaho;Image;improved;Institution;Institutional Review Boards;Intervention;Investigation;Investigational Drugs;Investigational Therapies;investigator-initiated trial;Knowledge;knowledge integration;Malignant Neoplasms;Medical Oncology;Mission;Monitor;Montana;National Comprehensive Cancer Network;Nevada;Oncology;operation;Pathology;Patients;Pharmacy facility;Policies;Population;Population Sciences;Prevention;Procedures;Process;programs;protocol development;Protocols documentation;Radiation Oncology;rare cancer;Research;Research Activity;Resources;Review Committee;Running;Services;Site;Specimen Handling;success;System;Time;Translational Research;Treatment Protocols;trend;Universities;Utah;Work;Wyoming

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE This is the fourth competing renewal of the Pitt Integrated Clinical and Geroscience Research Training Program T32 with an overarching long-term goal to produce a new generation of investigators committed to performing collaborative aging research across clinical, translational, and basic sciences. The University of Pittsburgh offers an outstanding milieu for this training, with exceptional depth and breadth of multidisciplinary aging research; experienced, involved, and well-funded mentors; and extensive resources for training in aging research across the clinical, translational, and biological perspective. The training program – one of only a few in the nation to train within an integrated clinical and biological perspective – focuses on two levels of trainees: 1) a 2-to-3-year postdoctoral program for physician investigators and postdoctoral fellows and 2) a 2-to-3-year predoctoral MD/PhD training program integrated into the University of Pittsburgh School Of Medicine Medical Scientist Training Program and select other Pitt predoctoral students with career interests in multidisciplinary aging research.

PI_NAMEs: FORMAN, DANIEL E. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-3 (J2)]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Recent advances, largely technology-based, are improving the diagnosis and management of cancer. However, despite a need, individuals from underrepresented groups and cross-trained in cancer biology research and metabolic studies are rare. The CMTP T32 postdoctoral training program addresses this need by providing a unique learning experience focused on cutting edge training in translational cancer metabolism research with exceptional institutional support for stipends, research funds and research environment. In this, the pipeline of cancer metabolism-talent and breakthrough discoveries will be enriched, locally at COH and beyond to patients worldwide.

PI_NAMEs: ANN, DAVID K. (contact);SEEWALDT, VICTORIA L.

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Training Programs;tumor metabolism

PROJECT_TITLE: Cancer Metabolism Training Program

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: DERMATOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Overall Narrative The SBDRC enhances research in cutaneous biology at Northwestern University and throughout the U.S. by providing networking and learning opportunities, advanced technology for performing studies, and shared data, thereby attracting new investigators into skin research. The Administrative Core, with its Enrichment, Pilot Grant, and Diversity-focused Programs, and the Research Cores will foster cooperative interactions among scientists and between scientists and clinicians, which will translate into innovative research, discovery, and ultimately better health care for patients with skin diseases.

PI_NAMEs: PALLER, AMY S (contact)

PROGRAM_OFFICER_NAME: GARCIA-CAZARIN, MARY

PROJECT_TERMS: 3-Dimensional;Address;Adopted;afferent nerve;Age;Animals;augmented intelligence;Award;Awareness;Back;Basic Science;bench to bedside;Bioinformatics;bioinformatics pipeline;bioinformatics resource;Biology;Biomedical Engineering;career development;Cell model;cell type;Cells;Cellular biology;Clinical;clinical application;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Complex;cost effective;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Cutaneous;data sharing;Databases;design and construction;Developmental Biology;Disease;disease model;Education;Educational workshop;Electroporation;empowerment;Epigenetic Process;epigenomics;Equipment;Equity;Ethnic Population;Faculty;Female;Fibroblasts;Fostering;Future;Gene Expression;Gene Modified;Generations;Genes;Genetic;genetic manipulation;genome-wide;genomic tools;Goals;Grant;Healthcare;High Density Lipoproteins;Histology;Human;human disease;Hypersensitivity skin testing;Image;Immune;Immunobiology;Immunofluorescence Immunologic;Immunohistochemistry;Immunologic Monitoring;Immunology procedure;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Informatics;Infrastructure;innovation;Instruction;instrument;instrumentation;Investigation;keratinocyte;knockout gene;Knowledge;Laboratories;Learning;Libraries;male;Medicine;meetings;melanocyte;member;Mentors;Microfluidics;Minority;Mission;Modeling;Morphology;mouse model;Mus;nano;nanoparticle;Nanotechnology;news;next generation;novel;Occupational activity of managing finances;Patient Care;Patients;Pattern;Population Heterogeneity;Positioning Attribute;Productivity;programs;protein expression;Protocols documentation;racial population;real time monitoring;repository;Research;Research Personnel;Resources;RNA Interference;Scientist;sensor;Series;Services;sex;Site;Skin;skin color;skin disorder;Skin Tissue;social media;spectrograph;Spherical Nucleic Acids;Structure;symposium;System;Techniques;Technology;Testing;Therapeutic;three-dimensional modeling;Tissue Engineering;Tissues;tool;Training;transcriptomics;Translating;Translational Research;translational study;Underrepresented Populations;Universities;vector;Viral;Vocational Guidance;web site

PROJECT_TITLE: Northwestern University Skin Biology and Diseases Resource-based Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

PHR: Administrative Core Narrative The overall objective of the Administrative Core is to coordinate and oversee all activities of the SBDRC. The Administrative Core organizes opportunities for learning, networking, and communication, provides pilot grants, and schedules meetings of Center leaders, Boards and scientists at Northwestern and nationally.

PROJECT_TITLE: Northwestern University Skin Disease Research Center Resource-based Center


PHR: STEM Core Project Narrative Skin culture models provide a powerful, safe and reliable tool to understand the mechanisms of skin diseases and test new therapies and devices under well-controlled experimental conditions. The Skin Tissue Engineering and Morphology Core delivers expertise, materials and technical support in the use of skin culture models to enable investigators to address skin-relevant questions in biomedical science.

PI_NAMEs: GREEN, KATHLEEN JANEE (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adopted;Age;Automobile Driving;Awareness;Basic Science;biobank;Biocompatible Materials;Biology;Biomedical Engineering;Cell Separation;cell type;Cells;Chemistry;Client;Collaborations;Communication;Communities;Complex;computerized tools;Cutaneous;data sharing;Databases;Deposition;Dermatology;Development;Device or Instrument Development;Devices;Disease;disease model;drug discovery;Drug Modelings;Education;Educational process of instructing;Educational workshop;Emerging Technologies;empowerment;Engineered skin;Engineering;Ensure;Ethnic Origin;Evaluation;Event;Fostering;Funding;Gene Expression;Goals;Hand;Histologic;Histological Techniques;Histology;Human;Hypersensitivity;Hypersensitivity skin testing;Image;imaging capabilities;Immune;Immunology;Incubators;Individual;Inflammatory;innovation;instrument;interest;Internships;Investigation;knock-down;Knowledge;Laboratories;Left;Manuals;mechanical properties;Mechanics;member;Mentors;Mentorship;Methods;Mission;Modeling;Morphology;multidisciplinary;Mus;next generation;novel;novel therapeutics;Patient Care;Patients;Physiological;programs;promoter;protein expression;Proteins;Protocols documentation;Race;Reagent;repository;Research;Research Methodology;Research Personnel;Research Technics;Resources;Sampling;Science;Scientist;Services;sex;Skin;skin disorder;skin morphogenesis;Skin Tissue;spatiotemporal;Specimen;stem;Structure;System;Therapeutic;Tissue Engineering;tissue processing;Tissue Sample;Tissues;tool;Training;Training and Education;Translational Research;translational study;Translations;Universities;virology;Work

PROJECT_TITLE: Core B - Stem


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Data Science;Genetics;Human Genome

PHR: TEST IT2 Core Narrative The TEST IT2 core will provide samples of perturbed and healthy human skin, immune testing using advanced technologies, bioinformatics for big data analysis, and the educational underpinnings to understand each element of the core and learn about the keratinocyte and its environment.

PI_NAMEs: LE POOLE, I. CAROLINE (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adopted;Affect;Animal Model;Applications Grants;base;Basic Science;Big Data;biobank;Bioinformatics;bioinformatics pipeline;bioinformatics resource;Biological;Biology;biomarker panel;Blood;Catalogs;Cell Extracts;Cell Physiology;Cells;Chemicals;Client;Clinic;Clinical;Clinical Research;Code;cohort;Collaborations;Communities;Complex;Computational algorithm;computer infrastructure;Consent;Consultations;cost;COVID-19;Data;Data Analyses;data sharing;Databases;Dedications;Dermatology;Dermatopathology;Development;Dimensions;Disease;Education;Elements;Environment;environmental agent;Epithelium;Equipment;Equipment and supply inventories;Evaluation;Experimental Designs;experimental study;Exposure to;Flow Cytometry;Freezing;Future;Generations;Genetic;genetic manipulation;Genomic approach;genomic data;Genomics;Goals;Harvest;healthy volunteer;help-seeking behavior;High Performance Computing;Human;human subject;human tissue;Hypersensitivity skin testing;Immune;Immunologic Tests;in vivo monitoring;Individual;Inflammation;Inflammatory;Informatics;innovation;insight;Institutional Review Boards;instrument;instrumentation;interest;Investments;Irritants;keratinocyte;Knowledge;Laboratories;large datasets;Learning;learning materials;Mediation;meetings;member;Methodology;Methods;Microbe;Molecular;Molecular Analysis;Monitor;multidimensional data;multiple omics;new technology;next generation;Paraffin;Patch Tests;Patients;Pharmaceutical Preparations;Process;Proliferating;Proteome;Proteomics;Protocols documentation;Radiation;reconstitution;reconstruction;Records;recruit;Recurrence;remote consent;repository;Research;Research Design;Research Personnel;Research Project Grants;Resources;response;Role;Sampling;Scientist;Secure;Series;Services;Signal Transduction;single cell genomics;Skin;skin barrier;skin disorder;Solid;Specimen;Stains;symposium;technological innovation;Technology;Testing;Tissues;tool;Traction;Training;training opportunity;transcriptome;transcriptomics;Translating;Translational Research;ultraviolet irradiation;Universities;Validation;Vendor;volunteer;Work

PROJECT_TITLE: Core C-Test IT


PHR: GET iN Narrative The GET iN Core generates viral and nonviral constructs for delivering genes and proteins into cells and skin. The Core provides counseling to scientists and hosts an educational program about gene manipulation, gene editing, and delivering genetic materials into skin.

PI_NAMEs: BUDUNOVA, IRINA  (contact)

PROJECT_TERMS: 3-Dimensional;base editing;bench-to-bedside translation;Biocompatible Materials;Biology;Cell Line;Cell Nucleus;Cells;clinical investigation;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complementary DNA;Complex;Consultations;Counseling;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Disease;DNA;DNA delivery;Drug Delivery Systems;Education;Epigenetic Process;epigenomics;Epithelial Cells;Equipment;Experimental Designs;gain of function;gene discovery;Gene Expression;gene function;Gene Modified;gene therapy;Genes;Genetic;genetic approach;genetic manipulation;Genetic Materials;Genetic Screening;genome editing;genome wide screen;genome-wide;genomic tools;Goals;Grant;Guide RNA;High Density Lipoproteins;Human;human model;In Vitro;in vivo;Individual;innovation;knock-down;knockout gene;Libraries;Lipoproteins;loss of function;Mediating;member;Methods;Mission;Modification;Mus;nanocarrier;nanolipoprotein particles;Nanotechnology;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;novel strategies;nucleofection;Organism;overexpression;precise genome editing;preclinical trial;Productivity;programs;Proteins;Reagent;repository;Reproducibility;Research;Research Personnel;Resources;RNA;Scientist;Services;Skin;skin barrier;skin disorder;small hairpin RNA;Small Interfering RNA;Spherical Nucleic Acids;System;Therapeutic Intervention;three dimensional cell culture;Tissues;tool;Toxic effect;Translational Research;Universities;Viral;viral gene delivery;Viral Vector

PROJECT_TITLE: Core D-Get IN


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: VERMILLION

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH DAKOTA

ORG_STATE: SD

PHR: Project Narrative This project aims to improve cervical cancer (CC) screening rates for Indigenous women by using an innovative mobile web app intervention called wPap. Specifically targeting Indigenous women living on the Yankton Sioux Tribe Reservation in South Dakota, the project will develop and evaluate the efficacy and feasibility of the theory-driven, culturally-tailored, multilevel, and multimedia wPap intervention. By offering a low-cost and easily replicable alternative to existing interventions, the project seeks to increase CC screening rates, reduce cancer-related health disparities, and enhance health outcomes for underserved Indigenous women at both local and national levels.

PI_NAMEs: ROH, SOONHEE  (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: 2 arm randomized control trial;Address;Adopted;Adult;Age;aged;Attitude;Behavioral;Belief;Cancer Control;cancer health disparity;Cancer Prevention Intervention;cancer type;Cervical Cancer Screening;Clinical;Communities;community based participatory research;Control Groups;cost;Country;Diagnosis;Early Diagnosis;Early Intervention;Educational Intervention;Educational Materials;effective intervention;efficacy evaluation;efficacy testing;Eligibility Determination;Evaluation;evidence base;experience;Focus Groups;follow-up;Fright;Geographic Locations;Geography;Goals;group intervention;Health;health care availability;Health Personnel;Healthcare;Healthcare Systems;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;improved;Indian reservation;Indigenous;indigenous community;Individual;Infection;information gathering;Infrastructure;innovation;Intervention;Interview;Knowledge;Malignant neoplasm of cervix uteri;Malignant Neoplasms;member;Mental Health;Methodology;Methods;mHealth;mobile computing;Modeling;Morbidity - disease rate;mortality;Multimedia;Northern Plains;Not Hispanic or Latino;Outcome;Participant;physical conditioning;Population;post intervention;Poverty;Prevention;Preventive care;preventive intervention;Printing;programs;Public Health Practice;Randomized;recruit;Reduce health disparities;Reporting;Research;response;Risk;satisfaction;screening;Screening for cancer;screening guidelines;Self Efficacy;Services;Sioux Indians;sociocultural determinant;South Dakota;structural determinants;Surveys;Technology;Testing;theories;tribal community;Tribal Elders;Tribal group;Tribes;Underserved Population;uptake;usability;Waiting Lists;web app;White Women;Woman

PROJECT_TITLE: A Mobile Web App Intervention to Promote Cervical Cancer Screening among Indigenous Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Scleroderma

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: This proposed Autoimmunity Center of Excellence, comprised of the Massachusetts General Hospital Rheumatology Division and the Ragon Institute, highlights the power of translational research that can occur when thoughtful and engaged clinical investigators team effectively with innovative basic researchers. Because IgG4-related disease (IgG4-RD) and giant cell arteritis (GCA) are fundamentally different conditions with regard to pace of disease and urgency of treatment, the designs of the Primary and Alternate Clinical Projects are geared to reflect these differences, underscoring the depth of clinical understanding that our group has for these conditions. The Collaborative Project, based on work from our group that builds upon a new human model of autoimmune fibrosis, points the way to new understanding of the relationships between autoimmunity and fibrosis.

PI_NAMEs: STONE, JOHN H (contact)

PROGRAM_OFFICER_NAME: FERGUSON, STACY E

PROJECT_TERMS: Affect;arm;Autoimmune;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;B-Lymphocyte Subsets;B-Lymphocytes;biobank;Biological Markers;biomarker discovery;Blood;BLR1 gene;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Communication;cell type;Cells;Centers of Research Excellence;Characteristics;Clinical;Clinical assessments;Clinical Investigator;Clinical Research;Clinical Trials;Collection;comparative efficacy;complement pathway;Cytotoxic T-Lymphocytes;Dendritic Cells;design;Disease;Disease remission;Dose;draining lymph node;efficacy evaluation;Event;Fibrosis;Flare;Formalin;FOXP3 gene;Functional disorder;Funding;General Hospitals;Genes;Genetic Transcription;health related quality of life;Hematopoiesis;Human;human model;humanized monoclonal antibodies;IgG4-related disease;IL17 gene;Immune;immune cell infiltrate;Immune System Diseases;Immune Tolerance;Immunology;Infiltration;Inflammatory;innovation;instrument;Interleukin 6 Receptor;Laboratories;Link;lymphoid organ;Maintenance;Maps;Massachusetts;Modeling;Multiple Myeloma;Mutation;open label;Organ;Paraffin;Pathogenicity;Pathologic;Patients;Pattern;peripheral blood;Phenotype;Plasma;Population;predictive marker;Prednisone;programmed cell death protein 1;programs;Proteome;Randomized;Recurrent disease;Regulatory T-Lymphocyte;Relapse;Research;Research Institute;Research Personnel;Rheumatology;Risk Assessment;Role;Safety;safety assessment;Sampling;Scientist;serological marker;Shipping;single-cell RNA sequencing;Site;Systemic Scleroderma;Systems Biology;T-cell receptor repertoire;T-Lymphocyte Subsets;Temporal Arteries;Temporal Arteritis;Therapeutic;Time;Tissue imaging;Tissues;tocilizumab;tool;Toxic effect;transcriptomics;translational medicine;Translational Research;Transportation;Variant;Visual;Visualization;Withdrawal;Work

PROJECT_TITLE: Targeting T cell Subsets in Autoimmune Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 KGH-I (J1)]


ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative - Overall Musculoskeletal conditions affect one in two Americans. We are a group of 95+ researchers who study the underlying causes for musculoskeletal diseases like arthritis, back pain and osteoporosis. With this knowledge, we develop and test new strategies to treat these diseases, primarily using small animals to test proof of concept.

PI_NAMEs: SILVA, MATTHEW J (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;American;Animal Model;Animals;Area;Arthritis;Award;Back Pain;Basic Science;Behavior;Biology;Biomechanics;bone;Bone Injury;Career Mobility;Categories;cellular imaging;Center Core Grants;Communities;cost;cost effective;design;Development;Disease;Disseminated Malignant Neoplasm;diversity and inclusion;Education;Effectiveness;Engineering;Evaluation Research;Extramural Activities;Faculty;Fostering;Fracture;Funding;Future;Grant;Group Affiliation;Healthcare;high school;Histology;imaging modality;improved;in vivo;Institution;Instruction;Investments;joint injury;Knowledge;Leadership;Link;Measures;mechanical properties;medical schools;Medicine;member;Methods;Microscopy;Modeling;morphometry;mouse model;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal structure;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;Osteoporosis;outreach;outreach program;Pain;Pain Measurement;pre-clinical;pre-clinical research;Principal Investigator;programs;Publications;recruit;Reproducibility;Research;Research Personnel;Resources;response;Roentgen Rays;Secure;Series;Stains;Structure;symposium;Techniques;Testing;Tissues;Training;Training Support;Underrepresented Populations;United States;United States National Institutes of Health;Universities;University resources;university student;Washington;Work

PROJECT_TITLE: RESOURCE BASED CENTER FOR MUSCULOSKELETAL BIOLOGY AND MEDICINE

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 FY (M1)]


PROJECT_TERMS: Acceleration;Award;Basic Science;Biology;Biometry;career;Career Mobility;Collaborations;Communication;Communications Media;Communities;Consultations;Education;Educational workshop;Effectiveness;Ensure;Environment;Equity;equity, diversity, and inclusion;Evaluation;Event;experience;Extramural Activities;Faculty;Functional disorder;Funding;Grant;Hybrids;Institution;Investments;Lead;Leadership;Link;Measures;Medicine;member;Multimedia;Musculoskeletal;Musculoskeletal Diseases;news;next generation;operation;organizational structure;Orthopedic Surgery;outreach;Performance;Persons;pre-clinical;pre-clinical research;programs;Publications;PubMed;Recording of previous events;recruit;Reproducibility;Research;Research Personnel;Resources;response;Science;Series;Services;social;Students;symposium;Training;United States;United States National Institutes of Health;Universities;University resources;Visit;Washington;Work

PROJECT_TITLE: Core A-Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

PI_NAMEs: TANG, SIMON YUE-CHEONG (contact)

PROJECT_TERMS: 3D Print;Area;Award;Biology;bone;Bone callus;Bone remodeling;Calibration;Cartilage;Collaborations;Collection;Communities;Consult;Consultations;contrast enhanced;cost effective;Custom;Data;data acquisition;Data Analyses;data curation;data management;Data Set;Documentation;Dual-Energy X-Ray Absorptiometry;Educational workshop;Ensure;Equipment;Feedback;Fracture;Funding;Goals;Image;Imaging Techniques;Infrastructure;innovation;Intervertebral disc structure;Investments;Laboratories;long bone;Maintenance;Measurement;mechanical behavior;mechanical properties;Mechanics;Medicine;member;Methods;microCT;Morphology;Musculoskeletal;musculoskeletal imaging;Musculoskeletal structure;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel strategies;operation;Osteocytes;Outcome;Outcome Assessment;outreach;Productivity;programs;Protocols documentation;Publications;radiological imaging;Reproducibility;Research;Research Personnel;Research Support;Resolution;Resources;Schedule;Service provision;Services;skeletal disorder;spine bone structure;Structure;System;Techniques;Testing;Tissues;Torsion;Training;Training Programs;United States National Institutes of Health;virtual;web site;X ray microscopy

PROJECT_TITLE: Core B-Musculoskeletal Structure and Strength Core


PI_NAMEs: VEIS, DEBORAH J (contact)

PROJECT_TERMS: Accountability;animal tissue;Biology;calcification;Cell Physiology;cellular imaging;Chemicals;Communication;Communities;Complex;Computer software;Consultations;cost effective;cryostat;Data Analyses;Development;Disease;Educational workshop;Electron Microscope;Equipment;equipment training;experience;Extracellular Matrix;Fee-for-Service Plans;Fostering;Frozen Sections;Goals;Histologic;Histology;Homeostasis;human tissue;Image;Immunofluorescence Immunologic;In Situ;Individual;Location;Manuscripts;Medicine;meetings;member;Messenger RNA;Methods;Microscope;microscopic imaging;Microscopy;Microtome - medical device;Molecular;Molecular Analysis;morphometry;Musculoskeletal;Musculoskeletal System;Nature;novel strategies;online resource;Paraffin;Pathology;Play;Positioning Attribute;Principal Investigator;programs;Proteins;Protocols documentation;Publications;quality assurance;Quality Control;Reproducibility;Research;Research Personnel;Research Project Grants;Resources;RNA;Roentgen Rays;Services;Site;Skeleton;Stains;Standardization;Structure;Surveys;System;Techniques;Time;Tissues;tool;Training;Training Support;transcriptomics;Universities;Washington;web site;Work

PROJECT_TITLE: Core C-Musculoskeletal Histology and Morphometry Core


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Chronic Pain;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects;Rheumatoid Arthritis

PI_NAMEs: ABU-AMER, YOUSEF  (contact)

PROJECT_TERMS: Address;Aging;Animal Behavior;Animal Model;Animal Testing;Anti-Inflammatory Agents;Arthralgia;Arthritis;arthropathies;Awareness;Behavior;Benchmarking;biobank;Biocompatible Materials;Biological;Biological Assay;Biological Products;Biology;Biomechanics;bone;Bone Diseases;bone fracture repair;Bone Injury;Cells;Characteristics;cohort;Collaborations;Communities;COVID-19 impact;data integration;Degenerative polyarthritis;Development;Diabetes Mellitus;Disease;Disease Management;disease model;Epidemic;Euthanasia;Evaluation;Fracture;Fresh Tissue;Functional disorder;functional outcomes;Funding;Genes;Goals;Grant;Guidelines;Health;Histologic;Histology;Image;Immunohistochemistry;Inflammation;Inflammatory;Instruction;interest;joint function;joint injury;Joints;Knowledge;Locomotion;Measures;Mechanics;Medicine;Metabolic Diseases;Modeling;Molecular;mouse model;Mouse Strains;Mus;Musculoskeletal;next generation;novel therapeutic intervention;Obesity;outreach;Pain;pain relief;pain sensitivity;Pathology;Process;programs;Proteins;Protocols documentation;Quality Control;Reagent;repository;Reproducibility;Research;Research Personnel;Resources;Rest;Rheumatoid Arthritis;Rodent Model;Running;Sampling;Serum;Source;Supervision;Swelling;Symptoms;Testing;Therapeutic Intervention;Time;Tissue Banks;tissue resource;Tissues;Training;Training and Education;Traumatic Arthropathy;treadmill

PROJECT_TITLE: Core D-Animal Models of Bone and Joint Injury & Disease


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Persons with serious mental illness (SMI) experience one of the largest health disparities in the U.S., dying 10 to 20 years earlier than the overall population, primarily due to cardiovascular disease. The proposed Center to Accelerate Translation of Interventions to Decrease Premature Mortality in Persons with SMI will study implementation strategies to scale-up effective interventions to address cardiovascular risk behaviors (unhealthy diet, physical inactivity, tobacco smoking) and risk factors (obesity, hypertension, diabetes and dyslipidemia) among persons with SMI, with an explicit focus on health equity, partner engagement, methods innovations, and building capacity amongst researchers and community partners to enact our Center’s mission – to advance health equity so that persons with SMI can live long healthy lives.

PI_NAMEs: DAUMIT, GAIL L. (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Automobile Driving;Behavior Therapy;Behavioral;Biological;Biological Models;Biometry;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Cessation of life;Client;Clinical;Communities;community advisory board;community engagement;community partners;community partnership;community setting;Complex;Cost Measures;Death Rate;Diabetes Mellitus;Diet;Discipline;Disparity;Dyslipidemias;Economics;effective intervention;evidence base;Evidence based intervention;Exercise;experience;Faculty;Foundations;Funding;Future;Goals;Health behavior;health disparity;health equity;Health Food;Health Services Research;healthy weight;high risk population;Hybrids;Hypertension;implementation outcomes;implementation science;implementation strategy;implementation trial;improved;innovation;Intervention;Intervention Studies;Lead;Life Expectancy;Low income;Measurement;Measures;Mental Health;Methodology;Methods;Mission;Modeling;novel;Obesity;operation;organizational structure;Persons;Phase;Physical activity;physical conditioning;physical inactivity;pilot test;Policies;Policy Maker;Policy Research;Population;premature;Premature Mortality;preventable death;Primary Care;Process;Provider;Qualifying;Research;Research Personnel;response;Risk;Risk Behaviors;Risk Factors;Role;scale up;Science;Services;severe mental illness;social;social health determinants;synergism;System;Testing;tobacco cessation intervention;Tobacco smoking behavior;Training;training opportunity;Translations;Unhealthy Diet;weight loss intervention;Work;years of life lost;Youth

PROJECT_TITLE: Center to Accelerate Translation of Interventions to Decrease Premature Mortality in Persons with Serious Mental Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (01)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness;Social Determinants of Health

PROJECT_TERMS: Acceleration;Achievement;Address;Appointment;cardiovascular risk factor;Certification;Collaborations;Communication;Communities;community advisory board;community center;community engagement;community partners;community partnership;community research;Data Storage and Retrieval;Development;Discipline;Ensure;Environment;Equity;Evaluation;Event;Evidence based intervention;Faculty;faculty research;Feasibility Studies;Foundations;Funding;Future;Goals;Health;health care delivery;health equity;health training;implementation research;implementation strategy;improved;Infrastructure;innovation;Intervention;Lead;Leadership;meetings;member;Mental Health;Mentorship;Methodology;Methods;Mission;Monitor;National Institute of Mental Health;novel strategies;Occupational activity of managing finances;online course;operation;peer;peer support;Persons;Phase;physical conditioning;Policies;Postdoctoral Fellow;Premature Mortality;Process;Productivity;programs;Public Health;recruit;Reporting;Research;Research Activity;Research Institute;Research Personnel;Research Project Grants;research study;Resources;Role;scale up;Secure;Series;Services;severe mental illness;social;social determinants;social media;Specialist;Strategic Planning;Testing;Training;training opportunity;Training Programs;Translations;undergraduate student;Universities;Update;web site;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Cost Effectiveness Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Schizophrenia;Serious Mental Illness

PI_NAMEs: STUART, ELIZABETH A. (contact)

PROJECT_TERMS: Acceleration;Area;Behavior;Behavioral Sciences;Biometry;Clinical Research;Collaborations;Communication;Cost effectiveness research;Data Analyses;Data Collection;data management;data visualization;design;Development;Discipline;Disparity population;effective intervention;Ensure;Epidemiology;Evaluation;Evidence based intervention;Future;Goals;Health;health equity;Health Policy;Health Services Research;Hybrids;implementation outcomes;implementation research;implementation science;implementation strategy;implementation tool;implementation trial;improved;Individual;innovation;Internet;Intervention;Journals;Leadership;Longevity;Measurement;Measures;Methodology;Methods;Modeling;Persons;physical conditioning;Policies;Policy Research;Positioning Attribute;Premature Mortality;Production;Productivity;Public Health;Publications;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;scale up;Science;service providers;severe mental illness;Side;Sum;symposium;synergism;System;therapy development;Training;Translations;Underrepresented Populations;web site;webinar

PROJECT_TITLE: Methods Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Mental Illness;Nutrition;Obesity;Prevention;Rehabilitation;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Acceleration;Address;Adoption;arm;Behavior;Behavior Therapy;Behavioral;Body Weight decreased;budget impact;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Client;Climate;clinically significant;Communication;Communities;community organizations;community setting;cost;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Delaware;Diet;dietary;Disparity;Educational Curriculum;Educational Status;effective intervention;effectiveness evaluation;effectiveness/implementation trial;Elements;Equity;evidence base;Evidence based practice;executive function;Exercise;Funding;Future;General Population;Guidelines;Health behavior;health disparity;health equity;health inequalities;healthy lifestyle;Hybrids;implementation cost;implementation evaluation;implementation intervention;implementation measures;implementation strategy;implementation trial;improved;Individual;innovation;insight;International;Intervention;intervention delivery;Interview;Knowledge;Leadership;learning network;Measures;meetings;Memory impairment;Mental Health;mental health organization;mental state;Methods;National Institute of Mental Health;New Jersey;Obesity;Occupations;pandemic disease;Participant;peer;peer influence;Performance;Persons;physical conditioning;pilot trial;Policy Maker;Population;population health;Premature Mortality;Prevalence;preventable death;Program Sustainability;programs;psychiatric rehabilitation;Qualifying;Randomized;Replicating Effective Programs;Reporting;Risk Factors;scale up;sedentary;Self Efficacy;severe mental illness;Site;skill acquisition;social;Specialist;System;Testing;Time;Training;Translations;uptake;Weight;weight loss intervention;Weight maintenance regimen;Work;working group

PROJECT_TITLE: R01-Signature Project: A hybrid implementation trial testing strategies to scale an evidence-based weight management program for persons with serious mental illness


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

PI_NAMEs: PLATT, RHEANNA EDITH (contact)

PROJECT_TERMS: 3-Dimensional;Academy;Acceleration;Address;Adult;American;American Heart Association;Anhedonia;Behavior;Behavior Disorders;Behavioral;Body mass index;Body Weight decreased;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Caring;Client satisfaction;Climate;clinically significant;Cognitive;Collaborations;Communities;community setting;comorbidity;Competence;Complex;Coordinated Specialty Care;Counseling;Data;design;Development;Diet;dietary;early psychosis;effective intervention;effectiveness/implementation trial;efficacy trial;Emotional disorder;Ensure;Evaluation;evidence base;Evidence based intervention;Family;flexibility;Focus Groups;Functional impairment;Funding;General Population;Goals;Group Meetings;Health;Health behavior;health care settings;healthy lifestyle;healthy weight;implementation cost;implementation determinants;implementation intervention;implementation strategy;Impulsivity;Intervention;intervention refinement;Interview;Knowledge;Leadership;lifestyle intervention;Medical;member;Mental disorders;Mental Health;Methods;motivational enhancement therapy;National Institute of Mental Health;Needs Assessment;Obesity;Outpatients;Overweight;Parents;Participant;Patients;Pediatrics;Persons;Physical activity;Population;Positioning Attribute;Premature Mortality;Prevalence;primary outcome;Process;programs;Provider;psychosocial rehabilitation;Public Health;Recommendation;recruit;Replicating Effective Programs;Research Support;Risk;Risk Factors;Schools;secondary outcome;Self Efficacy;Series;serious emotional disturbance;Service delivery model;severe mental illness;Site;skills;Structure;Subgroup;Surveys;Symptoms;Testing;Therapeutic;Training;Translating;Translations;usability;Weight;Work;working group;Youth

PROJECT_TITLE: R34-2: Adapting an Evidence-based Healthy Weight Intervention for Youth with Serious Emotional Disturbance and Testing Strategies for Implementation by Community Mental Health Programs


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

PI_NAMEs: YUAN, CHRISTINA T. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Behavior;Biological Models;Calibration;candidate identification;Communities;community engagement;community partners;Complex;cost;dashboard;Data;Data Sources;Decision Making;design;Dose;dynamic system;effective intervention;evidence base;Evidence based intervention;Evidence based practice;Exploration, Preparation, Implementation, and Sustainment;Foundations;future implementation;Healthcare;implementation determinants;implementation efforts;implementation evaluation;implementation framework;implementation science;implementation strategy;implementation trial;Individual;innovation;Intervention;intervention delivery;Knowledge;Mental Health;Methods;Modeling;novel;Outcome;Persons;physical conditioning;Premature Mortality;Probability;Process;programs;Provider;Randomized;Recommendation;Research;Review Literature;scale up;Science;severe mental illness;Smoker;Smoking Cessation Intervention;System;Systems Integration;Testing;theories;Time;tobacco cessation intervention;Tobacco smoke;Tobacco smoking behavior;Training;Translations;uptake;user centered design;Variant;virtual;virtual laboratory;Work

PROJECT_TITLE: R34-3: Using Systems Science to Inform the Implementation and Scale-up of Evidence-based Tobacco Cessation Treatment in Community Mental Health Programs


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Hematopoiesis is the process of formation of all blood cell types in our body and is essential for our physiology and survival. Developmental origins of hematopoietic cells are established, but the molecular mechanisms of blood formation are less defined. This proposal establishes a crucial family of epigenetic modifiers (Tet enzymes) as key regulators of blood formation during development. Findings will expand our understanding of the molecular mechanisms of blood formation, with implications for treatment of blood disorders where Tets are mutated or dysregulated, as well as for generating blood cells from pluripotent cells for clinical use.

PI_NAMEs: DAWLATY, MEELAD  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Adult;Affect;Aorta;Apoptosis;Binding;Blood Cells;blood formation;blood treatment;Catalytic Domain;Cell Count;cell type;Cells;Clinical;demethylation;Deposition;Derivation procedure;Development;Dioxygenases;DNA;DNA Methylation;DNA Modification Methylases;DNA Modification Process;Dorsal;Down-Regulation;Embryo;Embryoid bodies;Embryonic Development;embryonic stem cell;Endothelial Cells;endothelial stem cell;Endothelium;Enhancers;Enzymes;Epigenetic Process;Family;Fetal Liver;Flow Cytometry;gastrulation;Gene Expression;Gene Silencing;Genes;GFI1 gene;Goals;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic gene;hematopoietic stem cell formation;Hematopoietic stem cells;hemogenic endothelium;Hypermethylation;Image Cytometry;Impairment;In Vitro;in vivo;Mediating;Methylation;Modeling;Modification;Molecular;Mouse Embryonic Stem Cells;mouse model;Mus;Mutate;novel;Outcome;Physiology;pluripotent stem cell differentiation;Pluripotent Stem Cells;Process;programs;Proteins;Publishing;recruit;Regulatory Element;Reporter;Role;single-cell RNA sequencing;Specific qualifier value;Stains;stem cells;Surface;Testing;Tetanus Helper Peptide;transcription factor;transcriptomics;Work;Yolk Sac

PROJECT_TITLE: Role of Tet enzymes in embryonic hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Telehealth

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Native Americans in Oklahoma endure a disproportionate burden of colorectal cancer incidence and colorectal cancer-specific mortality, which is partly explained by poor rates of follow-up diagnostic colonoscopy after an abnormal home stool test. The proposed study aims to co-develop and pilot test a culturally sensitive digital outreach intervention to increase motivation, reduce structural barriers, and, thus, improve rates of diagnostic colonoscopy. This study offers a substantial public health impact to reduce avoidable CRC morbidity and mortality among Native Americans, and will provide valuable insight on how to scale culturally sensitive digital outreach interventions across our Tribal partners in Oklahoma.

PI_NAMEs: NEIL, JORDAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Age;Appointment;Arapaho;Area;Cancer Etiology;Cessation of life;Characteristics;Cheyenne;Clinic;Clinical;Clinical effectiveness;Collaborations;Colonoscopy;Colorectal Cancer;colorectal cancer screening;community advisory board;comparison control;Consultations;design;Diagnosis;Diagnostic;digital;Disease;disparities in morbidity;disparity reduction;Early Diagnosis;Education;Effectiveness of Interventions;effectiveness/implementation trial;Elderly;Eligibility Determination;Feces;Focus Groups;follow-up;Future;Geographic Information Systems;Goals;Health;Health care facility;health equity;high risk;Home;Hospitals;hybrid type 1 trial;Hybrids;implementation context;implementation science;improved;Incidence;Individual;Inequity;information system analysis;Infrastructure;innovation;insight;Intervention;Interview;Libraries;Measures;men;mHealth;Morbidity - disease rate;mortality;Motivation;Native American population;Native Americans;Oklahoma;Outcome;outreach;Pamphlets;Participant;patient navigation;Patients;Penetration;personal narratives;Persons;Phase;pilot test;primary outcome;Procedures;Process;process improvement;programs;Public Health;Randomized;Recording of previous events;Reporting;Rural Community;Schedule;screening;screening disparities;Services;sex;Site;Stage at Diagnosis;telehealth;Testing;Text;Text Messaging;Time;Transportation;Travel;Treatment Efficacy;tribal member;tribal Nation;Tribes;United States;United States Indian Health Service;uptake;Visit;Woman

PROJECT_TITLE: Improving Rates of Diagnostic Colonoscopy in Native Americans through a Culturally Sensitive Digital Outreach Intervention


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE This Mental Health, Earlier ALACRITY Center addresses a key development driver of the youth mental health crisis: 1 in 5 children have a mental health diagnosis by the age of 3 but existing evidence-based tools and approaches have failed to be systematically implemented in routine primary. To achieve population reach, the proposed Center advances scalable approaches to pediatric primary care-based early mental health promotion via targeting toddler transdiagnostic behavioral vulnerability at the preclinical phase to impact lifespan mental health. The Center's unique equitable implementation framework, tools and strategies are poised to foster mental health equity, promote resilience, and reduce the public health burden of early-onset severe mental health problems for children and families with diverse lived experience, with innovations including quantitative tools for bias reduction, digitally delivered prevention for increased access, ongoing integration of community partner priorities and values, interactive provider training to improve confidence in developmentally-based decision making and accessible strategies for bridging the screening to services gap via heightened family engagement.

PI_NAMEs: SMITH, JUSTIN D;WAKSCHLAG, LAUREN S (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Acceleration;Address;Adoption;Age;anti-racism;Attention;Behavioral;care coordination;care systems;career development;Caregivers;case-based;checkup examination;Chicago;Child;Child health care;Child Rearing;Childhood;Chronic;Clinic;Clinical;Cluster randomized trial;Collaborations;Communication;Communities;community engagement;community partners;community partnership;Country;Decision Making;design;Development;Diagnosis;Diagnostic;digital;digital delivery;Disease;early childhood;early onset;Ecology;Elements;empowerment;Ensure;Equity;Ethics;evidence base;Evidence based intervention;Evidence based program;Exhibits;experience;Eye;Family;Fostering;Functional disorder;Goals;Health;health disparity;health equity;health service use;Health system;Healthcare;human centered design;implementation barriers;implementation framework;implementation strategy;improved;Incubated;inequitable distribution;Inequity;Informal Social Control;innovation;Intervention;Learning;lens;Life;life span;Lived experience;marginalized community;Mental association;Mental disorders;Mental Health;Mental health promotion;Mental Health Services;Methodology;Methods;National Institute of Mental Health;Neighborhood Health Center;novel;novel strategies;Patients;Pediatric Hospitals;Phase;Population;Positioning Attribute;practice-based research network;pre-clinical;preference;prevent;Prevention;prevention service;Preventive;Preventive healthcare;preventive intervention;Primary Care;primary care clinician;programs;promote resilience;Provider;Psychopathology;Public Health;racism;Readiness;Research;Research Personnel;Research Project Grants;Resources;response;Risk;routine care;School-Age Population;Schools;Science;screening;service gap;Severities;social;Strategic Planning;Structure;synergism;System;Testing;Toddler;tool;Training;trial design;Universities;Utah;Vision;Youth

PROJECT_TITLE: Advancing community-driven optimization for equitable implementation of early childhood mental health prevention in pediatric learning health systems: Mental Health, Earlier ALACRITY Research Center


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

PI_NAMEs: WAKSCHLAG, LAUREN S (contact)

PROJECT_TERMS: Acceleration;Accountability;Address;Advocate;anti-racism;Belief;Budgets;career development;Caregivers;Caring;Child health care;Childhood;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Communities;community center;community engagement;community partners;community partnership;Community Practice;Competence;Continuity of Patient Care;dashboard;design;Development;E-learning;early childhood;early-career faculty;Ensure;Equity;evidence base;Expert Systems;Faculty;Fellowship;First Independent Research Support and Transition Awards;Fostering;Goals;Grant;Growth;health disparity;health equity;Health system;Healthcare;human subject;Impact evaluation;implementation framework;implementation research;Incubated;Infrastructure;innovation;interest;Investments;Leadership;Learning;learning community;lens;marginalized community;meetings;Mental Health;Mental health promotion;Mentorship;Methods;Monitor;novel;Online Systems;operation;Outcome;Participant;Pediatric Hospitals;Pilot Projects;Play;Policies;Population;population health;practical application;Prevention;Primary Care;Procedures;Process;Program Development;programs;Protocols documentation;Psychopathology;Recording of previous events;Research;Research Personnel;Resources;Role;Science;Scientist;Structure;synergism;tool;Training;Translations;United States National Institutes of Health;Universities;Utah;Vision;Workforce Development

PROJECT_TITLE: Community and Scientific Engagement & Administration Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: SMITH, JUSTIN D (contact)

PROJECT_TERMS: Address;analytical method;Area;Behavioral Sciences;care systems;Caring;Charge;Child Rearing;Childhood;Clinical;Collaborations;Communities;Complex;computerized;design;Development;Diagnostic;digital health;early childhood;Early Diagnosis;Early Intervention;early onset;eHealth;Ensure;Equity;ethnic disparity;evidence base;Evidence based intervention;Family;health care delivery;health equity;health information technology;Health system;human centered design;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;improved;Incubated;Informal Social Control;Infrastructure;innovation;Intervention;Investments;Knowledge;Lead;Leadership;Learning;Logic;Measurement;Mediator;Mental disorders;mental function;Mental Health;Mental health promotion;Mental Health Services;Methodology;Methods;Modeling;multidisciplinary;National Institute of Mental Health;neurodevelopment;novel;parenting intervention;Phase;Pilot Projects;Positioning Attribute;practice setting;Prevalence;prevent;Prevention;preventive intervention;Primary Care;Psychometrics;Psychopathology;Public Health;racial disparity;Randomized;Research;Research Activity;Research Domain Criteria;Research Personnel;Research Priority;Research Project Grants;Resources;Risk;Role;routine care;scale up;Science;screening;Structure;synergism;System;Testing;theories;Time;tool;Training;Training Activity;Translational Repression;trial design;Underserved Population;Work;World Health

PROJECT_TITLE: Methods Incubation Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PROJECT_TERMS: acceptability and feasibility;Address;Adoption;African American;analytical tool;anti-racism;Behavioral;Black race;care systems;Caregivers;checkup examination;Child;Child health care;Child Rearing;Childhood;Chronic;Clinic;clinical decision support;clinical risk;cognitive load;Communication;Communities;cost;Decision Making;design;Development;Developmental Diagnostic;Diagnostic;digital;digital applications;early childhood;Early Diagnosis;Early identification;early onset;Educational Intervention;effective intervention;Effectiveness;effectiveness testing;effectiveness/implementation study;Ensure;Equity;Ethnic Population;Evaluation;evidence base;Evidence based intervention;Evidence based program;experience;Family;Family health status;Health;health application;health disparity;Health system;human centered design;Hybrids;Impairment;implementation barriers;implementation efforts;implementation fidelity;implementation outcomes;implementation process;improved;Individual;Inequity;Informal Social Control;innovation;instrument;Intervention;Investigational Therapies;Latino;Learning;Life;Link;Lived experience;lower income families;marginalized community;mental age;Mental Health;Mental health promotion;Methods;Modeling;Nature;Neighborhood Health Center;novel;Nursery Schools;nutrition;Onset of illness;Outcome;pandemic disease;parenting intervention;Parents;patient oriented;Phase;Population Heterogeneity;Predictive Analytics;predictive modeling;preference;prevent;Prevention;prevention service;preventive intervention;Preventive service;Primary Care;primary outcome;Probability;Process;process optimization;programs;promote resilience;Public Health;racial population;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Research Support;resilience;Resource-limited setting;Risk;Risk Assessment;Risk Reduction;routine care;Safety;safety net;scale up;screening;service delivery;skills;social;Spanish;Structure;support tools;Symptoms;Syndrome;System;telehealth;Testing;Theoretical model;theories;therapeutic target;Time;Toddler;tool;Training;Translating;Trust;Uncertainty;unconscious bias;uptake;urban area;Vaccines;Variant;virtual;Well Child Visits;Work

PROJECT_TITLE: Innovative Risk Calculator and Telehealth Delivered Parenting Program for Equitable Mental Health Promotion in Pediatric Primary Care: A Hybrid Type 3 Effectiveness-Implementation Study


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care

PI_NAMEs: SPENCER, ANDREA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;age group;anti-racism;arm;Behavior Control;Belief;Caregivers;Caring;Case Based Learning;case-based;Chicago;Child;Child health care;Child Mental Health;Childhood;Clinic;Clinical;cohort;Collaborations;Color;Communication;Communities;Community Health;Competence;Cultural Backgrounds;Decision Making;design;Development;early childhood;Early Diagnosis;Educational Curriculum;Equity;evidence base;Exercise;experience;Face;Family;Feasibility Studies;Feedback;Goals;health equity;health inequalities;Health system;human centered design;implementation outcomes;implementation strategy;implicit bias;improved;Incubated;Individual;innovation;Intervention;Interview;Knowledge;Learning;Maps;mental development;Mental Health;Methods;Modeling;Neighborhood Health Center;novel;Nursery Schools;Outcome;parenting intervention;Parents;pilot test;prevent;Prevention;Preventive;Preventive care;preventive intervention;Primary Care;primary care clinician;primary outcome;Process;Program Development;programs;Qualitative Research;Randomized;Randomized, Controlled Trials;Readiness;Recommendation;Reporting;Research;Research Methodology;Research Project Grants;Research Project Summaries;Risk;Science;screening;Screening procedure;Self Efficacy;Series;Services;skill acquisition;social;social stigma;Structure;Symptoms;Testing;Toddler;Training;Trust;Uncertainty;underserved community;Videoconferencing;Work

PROJECT_TITLE: Leveraging the Extension of Community Health-Outcomes (ECHO) telementoring program to improve family-centered and equitable communication about early mental health risk in pediatric primary care


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCHLEIDER, JESSICA LEE (contact)

PROJECT_TERMS: Academy;active control;Address;Adoption;Age;American;Appointment;Behavioral;Belief;caregiver interventions;Caregiver support;Caregivers;checkup examination;Child;Child Mental Health;Childhood;Clinical;Communities;community engaged approach;Complex;Coping Skills;Data;design;Development;Diagnostic;digital;Doctor of Philosophy;early childhood;Early identification;early screening;Educational process of instructing;Elements;Emotions;empowerment;Ensure;Equity;ethnic minority;Ethnic Population;evidence base;Evidence based intervention;Expectancy;experience;Family;Feeling hopeless;follow-up;Grant;Growth;Health Benefit;health disparity;Health Resources;Health system;help-seeking behavior;high risk;human centered design;improved;in vivo;informant;Intervention;Lead;Learning;life span;Link;Lived experience;Low income;Mental Depression;Mental Health;Mental Health Services;Methods;minority children;Motivation;online intervention;optimism;Outcome;Parents;pediatrician;Pediatrics;pilot trial;preference;Prevention;Preventive Health Services;Primary Care;primary care clinic;primary care setting;prototype;Public Health;racial minority;racial population;randomized, clinical trials;Recommendation;Reporting;Research;Research Project Grants;Research Project Summaries;Resources;response;Risk;School-Age Population;screening;Services;social stigma;sociodemographic group;Support System;Teenagers;Testing;therapy design;Toddler;tool;Underserved Population;uptake;usability;Variant;Well Child Visits;Youth

PROJECT_TITLE: Adapting and testing an adjunctive, digital single-session intervention to increase caregiver adoption of early childhood mental health preventive services


PI_NAMEs: BEIDAS, RINAD SARY (contact)

PROJECT_TERMS: Address;Adoption;Affect;Attention;Back;Bioethics;care delivery;Caregivers;Caring;Child;child mental health service;Childhood;Clinics and Hospitals;Collaborations;Communities;community engagement;community partners;Community Practice;Data Collection;design;Development;early childhood;Early identification;Early Intervention;early screening;effective intervention;effectiveness evaluation;Ensure;Equity;Ethics;Ethnic Population;Evaluation;evidence base;Evidence based practice;experience;Failure;Family;Future;future implementation;Goals;Health;health equity;Health system;Height;implementation efforts;implementation framework;implementation intervention;implementation science;implementation strategy;implementation study;improved;improved outcome;Incubated;Individual;Inequity;innovation;Intervention;Justice;Leadership;Learning;life span;Light;Mental Health;Mental Health Services;Methodology;Methods;minority communities;Minority Groups;Neighborhood Health Center;Outcome;Participant;Pathway interactions;Patients;Pediatric Hospitals;Prevention;Primary Care;Procedures;Process;programs;prospective;Public Health;racial population;Research;Research Project Grants;Research Project Summaries;Risk;screening;Screening Result;social stigma;Standardization;synergism;Time;Toddler;trial design;uptake;Utah;Voice;willingness;Work

PROJECT_TITLE: Anticipating and evaluating unintended consequences to center equitable implementation in pediatric mental health prevention


NIH_SPENDING_CATS: Mental Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The proposed T32 Integrated Mental Health Fellowship is designed to train clinician scientists who are interested in improving the quality of mental health care delivered in primary care, medical subspecialty, and school-based clinics. Faculty supervisors will include senior investigators in the University of Washington Departments of Psychiatry, Pediatrics, Family Medicine, as well as Kaiser Permanente Washington Health Research Institute, and the Puget Sound VA Health Services Research and Development (HSR&D) Center for Innovation. Postdoctoral fellows will engage in mentored research and receive training in biostatistics, epidemiology, health services research, and implementation science through coursework, seminars led by program faculty from two NIMH-funded P50 Centers, one-on-one mentoring, statistical consultation, journal clubs, grant writing bootcamps, and a weekly works-in-progress seminar.

PI_NAMEs: FORTNEY, JOHN C. (contact);UNUTZER, JURGEN

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Fellowship;Mental Health

PROJECT_TITLE: Integrated Mental Health Fellowship

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-L (01)]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE  A goal of the proposed Core Center for Musculoskeletal Biology and Medicine is to facilitate translational discovery, moving laboratory advances into the diagnosis and treatment of human musculoskeletal disease. The Center is organized to reflect the spirit of the broad, interdisciplinary mandate of NIAMS: to develop ‘cross- cutting’ research that integrates many disciplines and involves the interplay and collaboration of a diverse array of specialists from both basic and clinical areas.

PI_NAMEs: ALLISTON, TAMARA N (contact)

PROJECT_TERMS: Acceleration;Adoption;Animal Model;Animals;Archives;Area;base;bench-to-bedside translation;Bioinformatics;bioinformatics resource;Biological;Biology;biomechanical test;Biomechanics;biomedical imaging;California;career development;Cell model;Cells;Clinical;Clinical Data;clinical database;clinically relevant;Collaborations;Communication;Communities;Data;Data Science;Data Set;Dedications;Diagnosis;Discipline;Disease;disease phenotype;Diverse Workforce;Education;Educational Curriculum;epidemiologic data;Epidemiology;epidemiology study;Fostering;Functional disorder;Funding;Genetic;Genetic Databases;genomic data;Genomics;Goals;Grant;Health;Human;human imaging;human tissue;Image;Imaging Device;imaging modality;imaging study;improved;Infrastructure;innovation;Institution;Investigation;Investments;Laboratories;Leadership;Medical Imaging;Medicine;meetings;member;Mentors;Minority-Serving Institution;Modeling;multimodality;Musculoskeletal;Musculoskeletal Diseases;musculoskeletal imaging;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;outreach;Patients;Population;pre-clinical;programs;Protocols documentation;Publications;quantitative imaging;reconstruction;recruit;Reporting;Research;Research Design;Research Personnel;Research Support;Resources;Role;Rotation;Science;Scientist;Services;skeletal;Specialist;Specimen;success;symposium;synergism;System;Technology;Tissue Sample;Tissues;tool;Training;translational medicine;Translational Research;United States National Institutes of Health;Universities;Visit


PHR: PROJECT NARRATIVE Not Applicable

PROJECT_TERMS: Adoption;Advocate;Annual Reports;Applications Grants;Area;Award;Biology;Budgets;California;career;Categories;Charge;Collaborations;Communication;Communities;Community Medicine;cost effective;Ecosystem;Educational workshop;Evaluation;Expenditure;Financial Support;Foundations;Funding;Goals;Grant;Individual;innovation;Institution;Joints;knowledge integration;Leadership;Legal patent;Marketing;Medicine;meetings;member;Musculoskeletal;Newsletter;Office of Administrative Management;operation;outreach;Process;Productivity;Program Reviews;programs;Progress Reports;prospective;Publications;Records;recruit;Reporting;Research;Research Personnel;Resource Allocation;Resources;Review Committee;satisfaction;Science;Scientist;Series;Services;Stretching;Surveys;symposium;synergism;System;Technology;tool;Training;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Administrative and Enrichment Core


NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Machine Learning and Artificial Intelligence;Osteoarthritis;Osteoporosis

PI_NAMEs: SCHAFER, ANNE LOUISE (contact)

PROJECT_TERMS: Achievement;Address;Aging;analytical method;Archives;arthropathies;Artificial Intelligence;bench to bedside;Bioinformatics;bioinformatics resource;Biological;Biology;Bone Density;Bone Diseases;Center Core Grants;Characteristics;Clinical;clinical database;Clinical Research;Clinical Sciences;cohort;Collaborations;Communities;computing resources;Consultations;continuing medical education;Data;Data Analyses;Data Analytics;data management;Databases;Degenerative polyarthritis;design;DNA;Education;education resources;Educational process of instructing;Ensure;Epidemiologist;Epidemiology;experience;Face;Faculty;follow-up;Fracture;Funding;Genetic;genetic epidemiology;Genomics;Health;Hip Osteoarthritis;Human;Image;imaging Segmentation;innovation;investigator training;Knee Osteoarthritis;knowledge base;Learning;Link;longitudinal database;Magnetic Resonance Imaging;Medicine;member;men;Muscle;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new technology;novel;novel strategies;Observational Study;Orthopedic Surgery;Osteoporosis;osteoporosis with pathological fracture;Pathogenesis;Pathway interactions;Persons;pre-clinical;Productivity;programs;Proteomics;radiological imaging;randomized trial;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk Factors;Running;segmentation algorithm;Serum;Services;Teaching Method;Testing;tool;Training;trait;Translating;Translational Research;way finding;Whole Blood

PROJECT_TITLE: Epidemiology, Bioinformatics, and Study Design (EBSD) Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KAZAKIA, GALATEIA J (contact)

PROJECT_TERMS: Acceleration;Adoption;Animal Model;Animals;Artificial Intelligence;Biochemical;Biochemistry;biological systems;Biology;Biomechanics;biomedical imaging;Biopsy;Body Composition;bone;bone turnover;Cartilage;Clinical;clinical imaging;clinically relevant;Collaborations;Communities;Computer Analysis;computer science;Computer software;computerized data processing;Consultations;Data;density;design;Development;Disease;Dual-Energy X-Ray Absorptiometry;Education;Educational workshop;Evaluation;experience;Goals;Grant;high resolution imaging;Histologic;Histology;Human;Image;Image Analysis;image processing;imaging capabilities;Imaging Device;imaging facilities;imaging informatics;Improve Access;in vivo;Individual;innovation;instrumentation;interest;Investigation;Knowledge;Link;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;mathematical sciences;Measures;Medicine;member;Methodology;Methods;Minor;Mission;model organism;Morphologic artifacts;Motion;Multimodal Imaging;Muscle;Musculoskeletal;musculoskeletal imaging;Musculoskeletal System;Noise;novel;Optical Tomography;outreach;Physics;Physiology;Positron-Emission Tomography;pre-clinical;Procedures;Process;quantitative imaging;radiological imaging;reconstruction;Relaxation;Research;Research Personnel;Resources;serial imaging;Services;single photon emission computed tomography;statistics;Structure;Students;Techniques;Technology;Tissue Sample;Tissues;tool;Training;virtual;Visualization;web portal;Work

PROJECT_TITLE: Imaging Core


NIH_SPENDING_CATS: Aging;Bioengineering

PI_NAMEs: CHANG, WENHAN  (contact)

PROJECT_TERMS: Acceleration;Address;Adopted;Adoption;Advanced Development;Aging;aging population;Animal Model;Animals;Applications Grants;base;Big Data;Biological;Biology;Biomechanics;bone;bone mass;Cartilage;Cell model;Cells;Chondrocytes;Clinical Investigator;Communities;Complement;Consult;Consultations;Core Facility;cost effective;Critical Thinking;Data;Data Analyses;Degenerative polyarthritis;digital;Digital Libraries;Discipline;Disease;drug mechanism;Educational process of instructing;Educational workshop;epidemiologic data;Event;Experimental Designs;Extracellular Matrix;Female;Fostering;Genomics;Goals;Grant;Health;Health Services Accessibility;Homeostasis;Hormonal;Human;Hypocalcemia;improved;innovation;interest;Location;Manuscripts;Mechanics;Medicine;member;Metabolism;metabolomics;Methods;microCT;Microscopy;Molecular;Molecular Biology;mouse model;multimodality;Mus;Musculoskeletal;Musculoskeletal Diseases;Musculoskeletal System;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neurosciences;Neurosecretory Systems;novel therapeutics;Organ;Organism;Osteoporosis;Outcome;Output;Pain;Patients;Population;prevent;Prevention;Proteomics;Protocols documentation;PTH gene;Reagent;recruit;Referral and Consultation;Reproducibility;Research;Research Personnel;Resource Allocation;Resources;response;Role;Sampling;Scientist;Services;single-cell RNA sequencing;Site;skeletal;skeletal disorder;Skeletal Muscle;Skeleton;skills;success;Surveys;symposium;System;Techniques;Therapeutic;Tissues;tool;Training;Training Activity;Training and Education;transcriptomics;Vertebrates;X-Ray Computed Tomography

PROJECT_TITLE: Skeletal Biology and Biomechanics (SBB) Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Methamphetamine;Pediatric;Stimulant Use and Misuse;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

ORG_CITY: SAN BERNARDINO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

PHR: The overall purpose of these studies is to determine the relationships between early adolescent nicotine exposure and later abuse of methamphetamine. Understanding this relationship will allow for the discovery of new interventions that can prevent methamphetamine abuse. Additionally, this proposal will include adolescent female rats a group often ignored in preclinical research.

PI_NAMEs: CRAWFORD, CYNTHIA A. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Abstinence;Addictive Behavior;Adolescence;Adolescent;adolescent smoking;Adult;adverse outcome;Alcohols;Animal Husbandry;Anti-Inflammatory Agents;Attenuated;Behavior;Childhood;cigarette smoking;Cocaine;comorbidity;Cues;cytokine;Data;Data Analyses;Development;Dose;Drug Interactions;drug seeking behavior;early adolescence;Exclusion;experimental study;Female;Female Adolescents;Frequencies;General Population;Hormonal;Human;illicit drug use;Illicit Drugs;imaging study;Immunohistochemistry;Inflammation;inflammatory marker;Intake;interest;Interleukin-6;Intervention;Intravenous;Investigation;Knowledge;male;Measures;Methamphetamine;methamphetamine abuse;methamphetamine use;methamphetamine user;Microglia;neuroinflammation;Nicotine;nicotine exposure;nicotine treatment;Oral;Outcome Study;Pattern;Pharmaceutical Preparations;postnatal;pre-clinical;pre-clinical research;preclinical study;Predisposition;prevent;Procedures;Property;psychologic;Rattus;Relapse;Reporting;Research;response;Rewards;Rodent;Role;Self Administration;sex;skills;Social Change;Students;Technical Expertise;Testing;Therapeutic Intervention;therapeutically effective;TNF gene;tobacco products;Tobacco use;Training;Treatment outcome;Western Blotting;women's treatment

PROJECT_TITLE: Impact of adolescent nicotine exposure on methamphetamine self-administration in female rats

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-W (SU)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative The proposed short-term research traineeship program provides a pathway for pre-doctoral students in the clinical field of audiology to expand their knowledge of research and foster development of a research mindset. Completion of this research traineeship will facilitate progression towards a career in research as a clinician scientist. Supporting an increase in the clinician-scientist workforce will benefit society by ensuring a strong future for discovery and advances in hearing health and patient care.

PI_NAMEs: HOOD, LINDA J. (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Academic Medical Centers;Address;Aging;Animal Model;Area;Audiology;Auditory;Basic Science;Behavioral Research;Biomedical Research;career;Childhood;Clinical;Clinical Research;clinical training;Cochlea;Cochlear Implants;Collaborations;Communities;Credentialing;Data Analyses;design;Development;Doctor of Philosophy;Educational process of instructing;Ensure;Environment;evidence base;experience;Fatigue;Foundations;Funding;Future;Goals;graduate student;Grant;hands on research;Healthcare;Hearing;hereditary hearing loss;human model;Individual;Institution;Journals;Laboratories;Learning;Manuscripts;meetings;Modality;multisensory;neural;Patient Care;Patient-Focused Outcomes;Peer Review;Phase;Physiology;Positioning Attribute;pre-doctoral;Productivity;programs;Public Health;recruit;Reporting;Reproducibility;Research;Research Personnel;research study;Research Training;Science;Scientist;sensory cortex;Societies;Speech;Speech Perception;Students;Traineeship;Training;Translational Research;United States National Institutes of Health

PROJECT_TITLE: Developing Research Careers in the Hearing Sciences II

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (11)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PHR: PROJECT NARRATIVE By 6 years of age 73% of Alaska Native (AN) children in the Yukon-Kuskokwim (Y-K) region of southwestern Alaska have had a full mouth dental reconstruction (FMDR), requiring general anesthesia for extensive early childhood caries. Data indicate only 12% of Y-K children have an oral exam by age 24 months; in contrast almost 80% obtained standard childhood vaccinations. We propose a mixed methods comparative clinical effectiveness trial to study whether the use of care coordinators to educate caregivers and to assist in coordination between well child visits and dental visits at ages 0-24 months increases the proportion of children who receive oral health exams and interventions and reduces the incidence of ECC in AN children.

PI_NAMEs: THOMAS, TIMOTHY K (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: 6 year old;Address;Advocate;Affect;Age;Age Months;Alaska;Alaska Native;American Indians;Birth;care coordination;care systems;caregiver education;Caregivers;Caring;Child;Child Care;Child health care;child services;Childhood;Cities;Clinic;Clinical;clinical care;Collaborations;Communication;Communities;community clinic;Community Health;Community Health Aides;comparative;Computerized Medical Record;Consumption;cost estimate;Counseling;cultural competence;Data;deciduous tooth;Dental;Dental Care;Dental caries;Dental Hygiene;Dental Records;Dentists;design;Diet Habits;differences in access;Disparity;early childhood;Early Intervention;Education;effectiveness clinical trial;effectiveness evaluation;Elderly;evidence base;experience;General Anesthesia;Goals;Health;health organization;Health Personnel;Health Priorities;Health Status;Healthcare;Healthcare Systems;Home;implementation context;implementation design;implementation process;improved;Incidence;Indigenous;interest;Intervention;Interview;Knowledge;Life;Medical;Methods;Modeling;Monitor;Not Hispanic or Latino;Oral;Oral cavity;Oral health;Outcome;Outcome Assessment;Pain Free;Parenting Education;Parents;Performance;permanent tooth;Positioning Attribute;Prevention;Preventive care;Process;Protocols documentation;Provider;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;reconstruction;remote communities;Reporting;Role;satisfaction;Schedule;Schools;service coordination;Services;Site;Sleep;sugar;Surveys;sweetened beverage;System;Time;tooth filling;tooth surface;tribal health;United States Indian Health Service;Vaccination;Visit;Water;Water fluoridation;Well Child Visits;Work;Yukon Kuskokwim;Yup'ik

PROJECT_TITLE: Early Intervention for Childhood Caries to Address Alaska Native Disparities in Oral Health


NIH_SPENDING_CATS: American Indian or Alaska Native;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: FLAGSTAFF

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHERN ARIZONA UNIVERSITY

ORG_STATE: AZ

PHR: Project Narrative This project proposes to conduct research examining autism spectrum disorder (ASD) assessment practices and processes provided to Diné (Navajo) parents/guardians of children ages 2-6. The research will identify how ASD assessment practices align/misalign with Diné parent/guardian cultural beliefs; describe practitioner perspectives on how assessments are conducted with Diné children; and examine the cultural responsiveness strategies used by interdisciplinary assessment teams. The research findings will be used to develop guidelines for improving ASD assessment practices and processes for Diné parents/guardians and their children.

PI_NAMEs: HENDERSON, DAVIS E;JENSON, RONDA ;LINDLY, OLIVIA J (contact)

PROJECT_TERMS: Address;Advocate;Affect;Age;autism spectrum disorder;autistic;autistic behaviour;autistic children;Behavior;Belief;Caring;Child;Clinical;Clinical Psychology;Clinical Research;Code;Communities;community advisory board;cultural values;design;Development;Diagnosis;Diagnostic Services;Diné Nation;disability;Discipline;Disparity in diagnosis;early childhood;Elements;Equity;experience;Family;Family Study;Funding;Future;Goals;Guidelines;Health Psychology;improved;Indigenous;indigenous community;Inequity;Intervention;Interview;Knowledge;Language Pathology;lens;Literature;member;Methods;National Institute of Mental Health;National Institute on Minority Health and Health Disparities;Navajo;Outcome;Parents;Perception;Persons;Philosophy;Pilot Projects;Positioning Attribute;Process;Protocols documentation;Public Health;Recommendation;Research;Research Priority;response;screening;Services;sociocultural determinant;Special Education;Speech;Speech Pathology;stem;Strategic Planning;Structure;Surveys;Thinking;treatment services;Work

PROJECT_TITLE: Advancing Hózhó in Autism Assessment (AHAA) for Diné Families


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome;Precision Medicine

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The Precision Medicine Initiative Cohort Program will enroll one million volunteers into a national Biobank that broadly reflects the diversity of the U.S. population and help accelerate progress toward a new era of precision medicine on a larger scale than previously possible. The proposed Biobank will be a valuable resource of biological specimens and related health information from human volunteers that can then be used to address a wide range of scientific questions to improve public health. Mayo Clinic proposes to provide a state-of-the-art infrastructure and cost-effective services to ensure the success of the Precision Medicine Initiative Cohort Program.

PI_NAMEs: CEKANOVA, MARIA ;CICEK, MINE  (contact);MAGUIRE, ALANNA

PROGRAM_OFFICER_NAME: CAULDER, MARK

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;arm;Automation;biobank;Biological;Blood;Businesses;Characteristics;Client;Clinic;Clinical;Clinical Services;cohort;Collection;Committee Members;Complex;cost;cost effective;Data;Disaster Planning;Disease;Elements;Enrollment;Ensure;Environment;epigenomics;Feces;Fee-for-Service Plans;genetic disorder diagnosis;Genome;Genomics;Goals;Health;health management;Healthcare Systems;hospital care;Human Volunteers;improved;Individual;individualized medicine;Information Management;Infrastructure;Institution;Intention;International;Label;Laboratories;Laboratory Research;Life Style;Link;Logistics;Management Information Systems;Medical;Medical Records;metabolomics;microbiome;multidisciplinary;Participant;Patient Care;Patients;PMI cohort;Population;precision medicine;Precision Medicine Initiative;Prevention strategy;Process;programs;Protocols documentation;Public Health;quality assurance;Questionnaires;Recovery;recruit;Regulation;Research;Research Personnel;Resources;response;Retrieval;Robotics;Route;Saliva;Sampling;scale up;Scientific Advances and Accomplishments;Secure;Services;Site;Specimen;Specimen Handling;square foot;success;System;Technology;Tissues;transcriptomics;Transportation;treatment strategy;United States;Urine;virtual;volunteer;Work

PROJECT_TITLE: Precision Medicine Initiative Cohort Program Biobank

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-K(51)R]


NIH_SPENDING_CATS: Asthma;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Lung;Social Determinants of Health

PHR: The proposed research is relevant to public health because asthma, increasing in prevalence, represents a major national cost measured by both patient suffering and economic burden. Our studies proposed will provide a conceptual framework linking the environmental pollutant/allergen exposure, AhR signaling, ROS generation, and ox-CaMKII to mast cell activation and asthma development. In the long term, these studies may reveal novel therapeutic targets for allergy and asthma.

PI_NAMEs: GAO, PEISONG  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Address;Adenoviruses;airway epithelium;Allergens;Allergic;allergic airway inflammation;Allergic inflammation;Aromatic Polycyclic Hydrocarbons;Aryl Hydrocarbon Receptor;Asthma;Automobile Driving;calmodulin-dependent protein kinase II;cell motility;Characteristics;Conditioned Culture Media;Cost Measures;cytokine;Data Set;Development;Dictyoptera;Diesel Exhaust;Economic Burden;Engraftment;environmental allergen;Environmental Pollutants;Epithelium;experimental study;Exposure to;Extrinsic asthma;Generations;Goals;Hypersensitivity;In Vitro;in vivo Model;innovation;knock-down;Knockout Mice;Link;mast cell;Mediating;Mitochondria;Molecular;mouse model;Mus;new therapeutic target;novel;Oxidants;Particulate;Patients;Play;Prevalence;Production;prophylactic;Protein Isoforms;Public Health;Pulmonary Inflammation;receptor;Receptor Signaling;recruit;Research;Resistance;Respiratory Signs and Symptoms;Role;Source;System;Testing;Therapeutic;tool;Toxin;Transfection

PROJECT_TITLE: Environmental Pollutants Potentiate Allergic Inflammation via Functional Axis of Aryl hydrocarbon Receptor, ROS, and CaMKII in Asthma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(57)]