NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

PHR: Project Narrative One of the crucial tasks following the COVID-19 pandemic will be addressing the enduring consequences experienced by the millions of individuals who have recovered from the illness. This project aims to investigate the underlying causes of enduring olfactory, neurological, and cognitive symptoms that linger for months to years post-infection, even as systemic inflammation diminishes. We will explore potential interventions for addressing long COVID through the utilization of an innovative transgenic mouse model and state-of-the-art genetic techniques. 1

PI_NAMEs: LU, XIAOHONG  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 2019-nCoV;Acceleration;ACE2;Acute Respiratory Distress Syndrome;Address;Affect;age related;aging brain;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Anatomy;animal imaging;Animal Model;Animals;Anosmia;associated symptom;Autophagocytosis;Behavioral;Binding;Biological Assay;biosafety level 2 facility;Brain;Case Series;Cell Aging;cell injury;Cells;Cellular Stress;Cessation of life;Characteristics;chemobrain;Chronic;Chronic Fatigue Syndrome;Clinical;Cognitive deficits;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 susceptibility;Cutaneous;cytokine release syndrome;Data;Dementia;Dementia with Lewy Bodies;Dissection;DNA Damage;Drug or chemical Tissue Distribution;Etiology;experience;Functional disorder;Gene Expression Regulation;gene therapy;Genes;Genetic;genetic approach;Genetic Techniques;Genotoxic Stress;Hallervorden-Spatz Syndrome;Hamsters;Heterozygote;Hospitalization;Human;Huntington Disease;immunopathology;Impaired cognition;In Vitro;in vivo;Individual;Infection;Inflammation;Inherited;Injections;innovation;insight;Intervention;Investigation;Length;Lewy Bodies;Lewy Body Dementia;Lewy body pathology;Long COVID;longitudinal analysis;Lysosomes;Macaca;Mediating;Modeling;Molecular;molecular marker;mouse model;Multiple System Atrophy;Mus;mutant mouse model;Nature;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;Neurocognitive Deficit;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurologic Deficit;Neurologic Symptoms;Neurons;neuropathology;novel;Nucleic Acid Regulatory Sequences;olfactory bulb;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Persian Gulf Syndrome;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Post-Acute Sequelae of SARS-CoV-2 Infection;Postural Orthostatic Tachycardia Syndrome;Proteins;Reporter;Research;Resolution;response;Risk;Role;SARS-CoV-2 infection;SARS-CoV-2 spike protein;senescence;sensor;Severities;small molecule;Somatic Mutation;Structure;symptomatology;Symptoms;synucleinopathy;systemic inflammatory response;therapeutic target;tool;Transgenic Mice;Variant;Viral;Viral Pathogenesis;Virus;Virus Diseases;Visualization

PROJECT_TITLE: Mechanistic Investigation of Neuropathological Interactions between COVID-19 and Progression of Lewy Pathology and Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative HIV-1 has been a public health crisis for 40 years and still causes 690,000 deaths a year around the globe. The key to ending this crisis is an efficacious vaccine which can produce broad immune responses. This research will develop fundamental knowledge on a new approach to produce multiple broad immune responses simultaneously giving us more shots on goal for ending the HIV-1 pandemic.

PI_NAMEs: KULP, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: Affinity;Animals;Antibodies;Antibody Repertoire;Antibody Response;Antigens;Area;B cell repertoire;B-Lymphocytes;Binding Sites;Biological Models;biophysical properties;Cessation of life;Clinic;Clinical;Clinical Research;Custom;Data;design;Development;Engineering;Epitopes;experience;Frequencies;Germ Lines;global health;Goals;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immune response;Immunization;Immunoglobulins;Individual;innovation;interest;Investigation;Knock-in Mouse;Knowledge;lead candidate;member;Modeling;mosaic;mouse model;Mus;Mutation;nanoparticle;neutralizing antibody;next generation sequencing;nonhuman primate;novel strategies;pandemic disease;Pathway interactions;Persons;Phase;Physiological;Population;Pre-Clinical Model;Productivity;programs;prophylactic;Protein Engineering;Public Health;Research;response;Series;Structure;success;synergism;Technology;Testing;tool;Vaccination;vaccination strategy;Vaccine Design;vaccine effectiveness;vaccine-induced antibodies;Vaccines;Virus;Yeasts

PROJECT_TITLE: Investigation into the activation of multiple bnAb precursors using structure-designed immunogens and Ig knock-in mice

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: VERHAAK, ROEL GW (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acceleration;Advocate;Affect;Architecture;Blood;cancer genomics;cancer heterogeneity;Cancer Patient;cancer type;Cells;Chemicals;Chemistry;Chromosome Pairing;Chromosomes;Collaborations;combinatorial;Communities;computer scientist;Data;Diagnostic;DNA;Drug resistance;Drug Targeting;Early Diagnosis;Education;epigenomics;Evolution;experience;extrachromosomal DNA;Family;Fingerprint;Fostering;Funding Mechanisms;Gene Expression Regulation;Gene Order;Generations;Genes;Genetic;Genetic Transcription;Genome;genome sequencing;Human;Immune Evasion;Immune system;Immunobiology;Immunologics;Immunology;Immunotherapy;Infrastructure;innovation;insight;International;Licensing;Ligands;live cell imaging;machine learning algorithm;Maintenance;Malignant Neoplasms;mathematical model;Medicine;Modeling;Monitor;multiple omics;Mutation;novel;Nucleic Acids;Oncogenes;Patients;Pharmaceutical Preparations;prevent;Process;Productivity;programs;Research Personnel;Resources;Role;Therapeutic;time use;Tissues;tool;tumor;tumor growth;Tumor Promotion;whole genome;Work;yeast genetics;Yeast Model System

PROJECT_TITLE: eDyNAmiC - JACKSONLAB


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cachexia;Cancer;Microbiome;Nutrition

ORG_CITY: Newark

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PI_NAMEs: WHITE, EILEEN P. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Adipose tissue;Affect;Animals;Anorexia;anorexic;Atlases;Atrophic;Autophagocytosis;Behavior;behavioral study;Biological Markers;Blood;Body Composition;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;carcinogenesis;Catabolic Process;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical biomarkers;clinical care;clinical phenotype;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;cytokine;Data;Desire for food;Diagnosis;dietary;Eating;effective therapy;Endocrine;Energy Metabolism;Etiology;Fatty acid glycerol esters;Feeding behaviors;Future;GDF15 gene;Gene Expression Profiling;Genes;Genetic;Geography;gut microbiome;high risk;Histologic;Hormonal;Hormones;Human;Image;Immune;Immunology;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;insulin signaling;Interleukin-6;International;Intrinsic factor;Lead;Link;Lipolysis;lung microbiome;Malignant Neoplasms;Maps;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Methods;microbiome;microbiota;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Muscle;neoplastic cell;Neuroendocrinology;Neurologic;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;Nutrient;Organ;Pathway interactions;patient population;Patient Recruitments;Patients;Performance Status;pharmacologic;Phenotype;Physical Function;Physiological;Pre-Clinical Model;Prospective, cohort study;Quality of life;recruit;response;Risk;Science;Scientist;Skeletal Muscle;Specialist;System;Therapeutic;Time;Tissues;Translations;treatment response;tumor;tumor metabolism;tumor microenvironment;Ubiquitin;uptake;Validation;virtual;wasting;Wasting Syndrome;Whole Organism;Work

PROJECT_TITLE: CANCAN-RUTGERS


NIH_SPENDING_CATS: Cancer

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: No PHR

PI_NAMEs: MAJZNER, ROBBIE G. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TITLE: NexTGen - DFCI


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prevention

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

ORG_ZIPCODE: SW7 2AZ

PI_NAMEs: GUNTER, MARC JAMES (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Prevention;tumor molecular fingerprint

PROJECT_TITLE: PROMINENT: Discovering the molecular signatures of cancer PROMotion to INform prevENTion


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: YARMARKOVICH, MARK  (contact)

PROJECT_TERMS: Malignant Childhood Neoplasm;next generation;T cell therapy

PROJECT_TITLE: Next Generation T cell therapies for childhood cancers (NexTGen)


ORG_CITY: LA JOLLA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: BAFNA, VINEET  (contact)

PROJECT_TITLE: eDyNAmiC - UCSD


ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PI_NAMEs: HUI, SHENG  (contact)

PROJECT_TERMS: Address;Adipose tissue;Affect;Algorithmic Analysis;Animals;Anorexia;anorexic;anti-cancer treatment;Atlases;Atrophic;Autophagocytosis;Basic Science;Behavior;behavioral study;Biological Markers;Blood;Body Composition;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;cancer therapy;carcinogenesis;Catabolic Process;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical biomarkers;clinical care;clinical phenotype;Clinical Research;clinical subtypes;Clinical Trials;clinically relevant;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;cytokine;Cytometry;Data;Desire for food;Diagnosis;dietary;Eating;effective therapy;Endocrine;Energy Metabolism;Epidemiology;Etiology;Fatty acid glycerol esters;Feeding behaviors;Foundations;Future;GDF15 gene;Gene Expression Profiling;Generations;Genes;Genetic;Geography;Goals;gut microbiome;high risk;Histologic;Hormonal;Hormones;host neoplasm interaction;Human;Image;imaging Segmentation;Immune;Immunology;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;innovation;insulin signaling;Interleukin-6;International;Intervention;Intrinsic factor;Investigation;Isotopes;Lead;Life Expectancy;Link;Lipolysis;lung microbiome;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;microbial;microbiome;microbiota;molecular subtypes;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mus;Muscle;neoplastic cell;Neuroendocrinology;Neurologic;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;novel;nuclear imaging;Nutrient;Observational Study;optogenetics;Organ;Organoids;Pathway interactions;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Performance Status;Peripheral;pharmacologic;Phenotype;Physical Function;Physiological;Pre-Clinical Model;Prospective, cohort study;Quality of life;Recovery;recruit;response;Risk;Science;Scientist;Skeletal Muscle;Specialist;System;Therapeutic;Time;Tissues;tool;Toxin;Translations;treatment response;treatment strategy;treatment trial;tumor;tumor metabolism;tumor microenvironment;Ubiquitin;uptake;Validation;virtual;Vision;wasting;Wasting Syndrome;Whole Organism;Work;Xenograft procedure

PROJECT_TITLE: CANCAN-HARVARDTHCHAN


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: CARDIFF

ORG_NAME: CARDIFF UNIVERSITY

ORG_ZIPCODE: CF24 0DE

PHR: No Text

PI_NAMEs: SEWELL, ANDREW  (contact)

PROJECT_TERMS: Address;Adult;Agreement;Antigens;Area;Autologous;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Back;bench to bedside;Biological;Brain Neoplasms;cancer cell;Cancer Patient;Cancer Relapse;cancer type;CAR T cell therapy;Cell Physiology;Cell Therapy;cellular engineering;Characteristics;chemotherapy;Child;Childhood;Childhood Cancer Treatment;Childhood Leukemia;childhood sarcoma;Childhood Solid Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical development;Clinical Research;clinical translation;Clinical Trials;Communities;comorbidity;Complex;Coupled;Coupling;Custom;Cytometry;Data;Data Collection;data complexity;data integration;data sharing;Databases;design;Development;diffuse midline glioma;Disease;engineered T cells;Engineering;Generations;Genetic Engineering;Heart;Hematologic Neoplasms;high risk;Immune;immune checkpoint blockade;Immune Evasion;Immunosuppression;Immunotherapy;improved;in vivo;in vivo Model;Knowledge;Learning;Life;Malignant Childhood Neoplasm;Malignant lymphoid neoplasm;Malignant Neoplasms;manufacture;Mass Spectrum Analysis;Methods;Modeling;Mutation;neoplastic cell;Neuroblastoma;next generation;novel;Operative Surgical Procedures;Patients;Pediatric Neoplasm;Pediatric Oncology;phase I trial;Plasma Cells;pre-clinical;Pre-Clinical Model;preclinical development;Primary Neoplasm;Program Development;programs;Protein Engineering;Radiation;receptor;Refractory;Relapse;Research Design;Research Personnel;Resistance;response;Route;sharing platform;small molecule;Solid;Solid Neoplasm;standard of care;Structure;Surface Antigens;Survival Rate;Survivors;System;T cell therapy;T-Lymphocyte;Technology;Testing;Text;Therapeutic;Toxic effect;Translating;tumor;tumor heterogeneity;tumor microenvironment;Vision;Work;Xenograft procedure

PROJECT_TITLE: NextGen - CARDIFF


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Obesity;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: COUNTER, CHRISTOPHER M (contact)

PROJECT_TERMS: Address;Aging;Alcohol consumption;anti-cancer research;Architecture;Bioinformatics;Biological;Biological Models;Body Weight decreased;Breast;Cancer Etiology;Cancer Model;cancer prevention;cancer risk;carcinogenesis;Cells;cellular targeting;chemical property;chemotherapy;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal;Communities;Country;CRISPR screen;Data;data integration;Data Set;detection method;Development;DNA;driver mutation;Endogenous Factors;Endometrial;Environment;environmental agent;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenomics;Epithelial Cells;Event;Excision;experience;Exposure to;Gene Expression;Generations;Genetic;genome-wide;Genomics;Goals;hematopoietic tissue;High-Risk Cancer;Human;human tissue;immune cell infiltrate;in vivo Model;Individual;Inflammation;inhibitor;innovation;Intervention;Intervention Studies;Investigation;Life Style;lifestyle factors;Limited Stage;Link;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;Mutate;Mutation;Neoplasms;neoplastic;Normal Cell;Normal tissue morphology;novel;Obesity;Organoids;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Population;Prevalence;Process;promoter;Proteome;Proteomics;Research Personnel;response;Risk;Risk Factors;Role;Route;Sampling;small molecule;smoking cessation;stem;stem cells;Structure of parenchyma of lung;Testing;Time;Tissue Donors;Tissue imaging;Tissue Sample;Tissues;tool;transcriptomics;tumor;Tumor Promoters;Tumor Promotion;Tumor stage;Tumor Tissue;tumorigenesis;Unhealthy Diet;whole genome

PROJECT_TITLE: PROMINENT-DUKE


ORG_CITY: GLASGOW

ORG_NAME: BEATSON INSTITUTE FOR CANCER RESEARCH

ORG_ZIPCODE: G61 1BD

PI_NAMEs: LEWIS, DAVID Y (contact)

PROJECT_TERMS: Address;Adipose tissue;Affect;Algorithmic Analysis;Animals;Anorexia;anorexic;anti-cancer treatment;Atlases;Atrophic;Autophagocytosis;Basic Science;Behavior;behavioral study;Biological Markers;Blood;Body Composition;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Model;Cancer Patient;cancer therapy;carcinogenesis;Catabolic Process;Cells;Characteristics;chemotherapy;Classification;Clinic;Clinical;clinical biomarkers;clinical care;clinical phenotype;Clinical Research;clinical subtypes;Clinical Trials;clinically relevant;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;cytokine;Cytometry;Data;Desire for food;Diagnosis;dietary;Eating;effective therapy;Endocrine;Energy Metabolism;Epidemiology;Etiology;Fatty acid glycerol esters;Feeding behaviors;Foundations;Future;GDF15 gene;Gene Expression Profiling;Generations;Genes;Genetic;Geography;Goals;gut microbiome;high risk;Histologic;Hormonal;Hormones;host neoplasm interaction;Human;Image;imaging Segmentation;Immune;Immunology;improved;improved outcome;in vivo;Inflammatory;Inflammatory Response;innovation;insulin signaling;Interleukin-6;International;Intervention;Intrinsic factor;Investigation;Isotopes;Lead;Life Expectancy;Link;Lipolysis;lung microbiome;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Mediator;Medical;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;microbial;microbiome;microbiota;Mission;molecular subtypes;mortality;mouse model;multicatalytic endopeptidase complex;multidisciplinary;Mus;Muscle;neoplastic cell;Neuroendocrinology;Neurologic;Neurosecretory Systems;Non-Small-Cell Lung Carcinoma;novel;nuclear imaging;Nutrient;Observational Study;optogenetics;Organ;Organoids;Pathway interactions;patient population;Patient Recruitments;Patient-Focused Outcomes;Patients;Performance Status;Peripheral;pharmacologic;Phenotype;Physical Function;Physiological;Pre-Clinical Model;Prospective, cohort study;Quality of life;Recovery;recruit;response;Risk;Science;Scientist;Skeletal Muscle;Specialist;System;Therapeutic;Time;Tissues;tool;Toxin;Translations;treatment response;treatment strategy;treatment trial;tumor;tumor metabolism;tumor microenvironment;Ubiquitin;uptake;Validation;virtual;Vision;wasting;Wasting Syndrome;Whole Organism;Work;Xenograft procedure

PROJECT_TITLE: The CANcer Cachexia Action Network (CANCAN):a Multidisciplinary Virtual Institutewith the Mission to Cure Cancer CachexiaCANCAN - BEATSON


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

PI_NAMEs: MUSTIAN, KAREN M. (contact)

PROJECT_TITLE: CANCAN - ROCHESTER


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PI_NAMEs: BALMAIN, ALLAN  (contact)

PROJECT_TITLE: PROMINENT - UCSF


PI_NAMEs: BOEKE, JEF D (contact)

PROJECT_TITLE: eDyNAmiC - NYU


ORG_CITY: CAMBRIDGE

ORG_NAME: UNIVERSITY OF CAMBRIDGE

ORG_ZIPCODE: CB2 1TN

PI_NAMEs: BIFFI, GIULIA  (contact);O'RAHILLY, STEPHEN

PROJECT_TITLE: CANCAN - Cambridge


ORG_CITY: LYON

ORG_COUNTRY: FRANCE

ORG_FIPS: FR

ORG_NAME: INTERNATIONAL AGENCY FOR RES ON CANCER

PI_NAMEs: BRENNAN, PAUL JOSEPH (contact)

PROJECT_TERMS: Address;Aging;Alcohol consumption;anti-cancer research;Architecture;Bioinformatics;Biological;Biological Models;Body Weight decreased;Breast;Cancer Etiology;Cancer Model;cancer prevention;cancer risk;carcinogenesis;Cells;cellular targeting;chemical property;chemotherapy;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Colorectal;Communities;Country;CRISPR screen;Data;data integration;Data Set;detection method;Development;DNA;driver mutation;Endogenous Factors;Endometrial;Environment;environmental agent;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;epigenomics;Epithelial Cells;Event;Excision;experience;Exposure to;Gene Expression;Generations;Genetic;genome-wide;Genomics;Goals;hematopoietic tissue;High-Risk Cancer;Human;human tissue;immune cell infiltrate;in vivo Model;Individual;Inflammation;inhibitor;innovation;International Agency for Research on Cancer;Intervention;Intervention Studies;Investigation;Life Style;lifestyle factors;Limited Stage;Link;Machine Learning;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Methods;Modeling;Molecular;Molecular Target;mouse model;multidisciplinary;Mus;Mutate;Mutation;Neoplasms;neoplastic;Normal Cell;Normal tissue morphology;novel;Obesity;Organoids;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Population;Prevalence;Process;promoter;Proteome;Proteomics;Research Personnel;response;Risk;Risk Factors;Role;Route;Sampling;small molecule;smoking cessation;stem;stem cells;Structure of parenchyma of lung;Testing;Time;Tissue Donors;Tissue imaging;Tissue Sample;Tissues;tool;transcriptomics;tumor;Tumor Promoters;Tumor Promotion;Tumor stage;Tumor Tissue;tumorigenesis;Unhealthy Diet;whole genome

PROJECT_TITLE: PROMINENT - IARC


PI_NAMEs: NIK-ZAINAL, SERENA  (contact)

PROJECT_TITLE: eDyNAmiC - CAMBRIDGE


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PI_NAMEs: CHEN, ZHIJIAN J (contact)

PROJECT_TITLE: eDyNAmiC-TEXASSW


ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: WEISSMAN, IRVING L. (contact)

PROJECT_TITLE: NexTGen - STANFORD


PI_NAMEs: MISCHEL, PAUL S (contact)

PROJECT_TITLE: eDyNAmiC - STANFORD


ORG_CITY: PARIS

ORG_NAME: INSERM PARIS 5

PI_NAMEs: DONNADIEU, EMMANUEL  (contact)

PROJECT_TITLE: NGTC - INSERM


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: UNIVERSITY COLLEGE LONDON

ORG_ZIPCODE: WC1E 6BT

PI_NAMEs: PULE, MARTIN  (contact)

PROJECT_TITLE: NGTC - UCL


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PI_NAMEs: AYRES, JANELLE S (contact)

PROJECT_TITLE: CANCAN - SALK


ORG_DEPT: BIOMEDICAL ENGINEERING

PI_NAMEs: LUNDBERG, EMMA  (contact)

PROJECT_TITLE: PROMINENT - Stanford


PI_NAMEs: JAMAL-HANJANI, MARIAM  (contact)

PROJECT_TITLE: eDyNAmiC - UCL


PROJECT_TITLE: CANcer Cachexia Action Network/CANCAN


ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PI_NAMEs: BOLLARD, CATHERINE M. (contact)

PROJECT_TITLE: NextGen - CRI


ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PI_NAMEs: CRAVATT, BENJAMIN F (contact)

PROJECT_TITLE: eDyNAmiC - SCRIPPS


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cocaine;Drug Abuse (NIDA only);Methamphetamine;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CINCINNATI

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Eﬀects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target trial emulation using patient electronic health records PROJECT NARRATIVE The proposed study would utilize TriNetX Analytics, a nationwide electronic health records (EHR) database, to evaluate semaglutide’s association with changes in both the incidence of StUDs (MUD, CUD) and clinical outcomes associated with StUDs. Outcomes will be separately assessed by age groups, sex, and race and in patients with co-occurring mental disorders or other substance use disorders (SUDs) including alcohol, nicotine, opioid, and cannabis use disorders, whenever sample sizes permit. Our methodology is based on our successful use of TriNetX Analytics to evaluate semaglutide’s association with reduced incidence and relapse of cannabis use disorder.

PI_NAMEs: WINHUSEN, T JOHN (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: addiction;Address;Adverse effects;age group;age stratification;aged;Agonist;Alcohol consumption;alcohol use disorder;Alcohols;Anecdotes;Attention;Cessation of life;Clinical;Clinical Trials;Cocaine use disorder;Data;Databases;Electronic Health Record;Ethnic Origin;General Population;GLP-I receptor;Incidence;marijuana use disorder;Mental disorders;Methamphetamine use disorder;Methodology;Nicotine;Nicotine Use Disorder;Non-Insulin-Dependent Diabetes Mellitus;Opioid;opioid use disorder;Outcome;Patients;Persons;Population;preclinical study;Race;Recording of previous events;Relapse;Reporting;Sample Size;sex;Smoke;smoking cessation;stimulant use;stimulant use disorder;Substance Use Disorder;United States Food and Drug Administration;Weight maintenance regimen

PROJECT_TITLE: CTN - Effects of semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro and Zepbound) on incidence and outcomes of stimulant use disorders and opioid use disorder in real-world populations: target tr


ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PI_NAMEs: JANOWITZ, TOBIAS  (contact)

PROJECT_TITLE: CANCAN - COLDSPRING


ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PI_NAMEs: PERRIMON, NORBERT  (contact)

PROJECT_TITLE: CANCAN - Harvard


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Prevention;Pulmonary Fibrosis;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Our overall goals are to utilize novel pro-apoptotic host-directed therapies to develop short (2-3 months versus current 4-6 months), and efficacious TB treatment regimens which also prevent / improve post- tuberculosis lung damage, as well as develop novel clinically-translatable imaging approaches to expedite the clinical development of pro-apoptotic drugs for shortening TB treatments.

PI_NAMEs: JAIN, SANJAY  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Adult;adverse outcome;Aftercare;Animal Model;Animals;Antibiotics;antimicrobial;Apoptosis;Apoptotic;Area;Autopsy;Autoradiography;BCL2 gene;Biological Availability;Bronchiectasis;cancer clinical trial;cancer therapy;CASP3 gene;Cell Death;Cells;Characteristics;Chemicals;Child;Chronic;Clinical;clinical development;clinical translation;cohort;Collagen;Complete Blood Count;Development;efficacy evaluation;Family;fibroblast-activating factor;Fibrosis;fibrotic lung;first-in-human;Flow Cytometry;Goals;Hematology;high dimensionality;High Resolution Computed Tomography;Histology;Image;image visualization;imaging approach;imaging biomarker;Immune;Immunology;Immunophenotyping;Impairment;improved;in vivo imaging;Induction of Apoptosis;Infection;Inflammation;inhibitor;insight;isoniazid;Ligands;Linezolid;Lung;lung injury;Macrophage;Magnetic Resonance;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measurement;Measures;Methods;molecular imaging;Morbidity - disease rate;Multi-Drug Resistance;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Necrosis;novel;novel therapeutics;Oncology;Oral;Oral Administration;Parents;Pathogenesis;Penetration;Pharmaceutical Preparations;Phase;Platelet Count measurement;Positron-Emission Tomography;Predisposition;prevent;Proliferating;Proteins;Pulmonary Fibrosis;pulmonary function;Pulmonary Tuberculosis;Pyrazinamide;Randomized;Regimen;Relapse;Research;Respiratory Signs and Symptoms;Rifampin;Role;serial imaging;Site;small molecule;Stains;Strategic Planning;Structure of parenchyma of lung;Technology;Time;Tissues;Toxic effect;treatment arm;Treatment outcome;Treatment Protocols;Tuberculosis;tuberculosis treatment;Vascular blood supply;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Pro-apoptotic Drugs as Host-Directed Treatments for Pulmonary Tuberculosis


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative (for public disclosure) We already identified ELQ-300 as a selectively potent inhibitor Qi site of the Plasmodium falciparum cytochrome bc1 complex. We have recently identified an ELQ derivative that is more potent in vitro and in vivo than ELQ-300 and now seek to modify the structure of this molecule to optimize for enzyme targeting to enhance antimalarial potency, selectivity, and overall performance in vitro and in vivo in rodent models of disease infection.

PI_NAMEs: RISCOE, MICHAEL KEVIN (contact);VAIDYA, AKHIL B

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Anti-malarials;Area;atovaquone;Biochemistry;Biological Availability;Bite;Blood;Blood Circulation;Canis familiaris;Case Management;Chemical Structure;Chemoprevention;Chemoprotection;Chloroguanide;Collaborations;Complex;cost;cost outcomes;crystallinity;Culicidae;Cytochrome bc1 Complex;cytotoxicity;design;Development;Digit structure;Disclosure;disease model;disease transmission;disorder prevention;Dose;Drug Combinations;drug efficacy;Drug Evaluation;Drug Exposure;Drug Kinetics;Drug Synergism;Enzymes;Esters;Exhibits;Exposure to;Floods;Formulation;Genotype;global health;Goals;Half-Life;Host Defense;Human;Implant;improved;improved outcome;In Vitro;in vitro activity;in vivo;Infection;Infection prevention;Ingestion;inhibitor;Injectable;Intestines;Journals;Lateral;lead candidate;Liquid substance;Liver;Malaria;Malaria prevention;Medicine;Metabolic;Methods;Midgut;Mitochondria;Modeling;Modification;Molecular;mouse model;Multi-Drug Resistance;Multienzyme Complexes;Mus;new therapeutic target;next generation;novel therapeutics;Oocysts;Oral;Oxygen;Parasites;Parasitology;Parents;Particle Size;Performance;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Phenotype;Plasmodium;Plasmodium falciparum;Population;pre-clinical;Predisposition;prevent outbreaks;Prevention;Prodrugs;Production;progenitor;Prophylactic treatment;Publishing;Qi;Rattus;Regimen;Resistance;resistant Plasmodium falciparum;resistant strain;risk minimization;Rodent Model;Route;Rupture;Safety;scaffold;Scientist;Seasons;Series;Side;Site;Solubility;Sporozoites;structural biology;Structure;Testing;Therapeutic;toxicant;translational potential;United States National Institutes of Health;Update;Variant;vector mosquito

PROJECT_TITLE: Next Generation ELQs for Treatment and Once-Monthly Protection Against Malaria

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(90)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Prior infection or intranasal vaccination establishes populations of tissue-resident memory T cells throughout the respiratory tract that can protect against experimental respiratory virus challenge by rapidly eliminating virus- infected cells and limiting immunopathology. This proposal seeks to define the ability of respiratory tract-resident memory CD8+ T cells to prevent viral propagation following natural respiratory virus transmission and identify mechanisms critical to this process. Our findings will provide valuable insights for the future development of cell- mediated vaccines designed to provide broad protection against viral strains and limit the spread of respiratory viruses in the population.

PI_NAMEs: KOHLMEIER, JACOB E (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Address;Adenovirus Vector;Aerosols;airway epithelium;Animals;Antibodies;Antibody Response;Antigen Presentation;antigen-specific T cells;Antigens;antiviral immunity;Area;burden of illness;Cavia;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Characteristics;Collaborations;conditional knockout;cytokine;Cytokine Signaling;Cytoprotection;Data;Development;Drug or chemical Tissue Distribution;efficacy evaluation;Engineering;Epithelial Cells;Epitopes;Event;Ferrets;flu;flu transmission;Future;Genes;Genetic;guinea pig model;Health;Human;human pathogen;Immune;Immunity;Immunization;Immunization Programs;Immunologics;immunopathology;Individual;Infection;Infection prevention;Influenza;Influenza Hemagglutinin;influenza virus vaccine;influenzavirus;insight;Investigation;Knockout Mice;Longevity;Lower respiratory tract structure;Lung;Mediating;Memory;Memory B-Lymphocyte;Modeling;Molecular;mouse model;Mucous Membrane;Mus;Mutate;Mutation;neutralizing antibody;novel strategies;pandemic disease;parainfluenza virus;pathogen;Population;Positioning Attribute;pressure;prevent;Process;programs;protective efficacy;Proteins;Regimen;Resistance;Respiration;respiratory;respiratory infection virus;Respiratory System;Respiratory Tract Infections;respiratory virus;response;RNA Viruses;Role;SARS-CoV-2 variant;seasonal influenza;Sendai virus;Series;single-cell RNA sequencing;Surface;T cell response;T memory cell;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;tissue resident memory T cell;tool;transcriptome sequencing;transmission process;Up-Regulation;Upper respiratory tract;Vaccinated;Vaccination;Vaccine Design;Vaccines;Variant;Viral;viral transmission;Virus;virus identification;Virus Replication

PROJECT_TITLE: Mechanisms of CD8 TRM-mediated protection against respiratory virus transmission

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition;Pediatric

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Human noroviruses are the leading global cause of childhood diarrhea and are attributed to the deaths of 200,000 young children each year. Understanding their pathogenesis, particularly in young hosts, is thus an important priority to aid in the development of vaccines and therapeutics. Our studies defining the mechanisms by which intestinal microbiota regulate norovirus pathogenesis should inform development of new types of treatment in this vulnerable population.

PI_NAMEs: KARST, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: absorption;Acute;Adult;Agonist;Antidiarrheals;antiviral immunity;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Breast Feeding;cell type;Cells;Cessation of life;Child;Childhood;Cholestasis;cohort;commensal bacteria;Complex;Data;Development;Diarrhea;Disease;Enteral;enteric virus infection;Enzymes;Equilibrium;Fatty acid glycerol esters;fetal;Functional disorder;Gastroenteritis;Goals;GPBAR1 gene;gut microbiota;Human;Human Milk;Immune;Immune response;Immunity;Immunologic Factors;Infant;infant infection;Infection;innovation;insight;Knowledge;Lactation;Malnutrition;mammary;Metabolic;Metabolic Biotransformation;Metabolism;microbiome;microbiota;Modeling;Mothers;Mus;Neonatal;neonatal health;neonate;new therapeutic target;Norovirus;novel;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Play;Predisposition;Pregnant Women;Process;receptor;receptor binding;Regulation;Research;Research Project Grants;Role;Severity of illness;Shapes;Signal Pathway;Source;Testing;Therapeutic;therapeutic evaluation;therapeutic target;trafficking;vaccine development;Viral;Viral Pathogenesis;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Regulation of enteric norovirus infection by host-derived and microbiota-transformed bile acids

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Arenaviruses are the causative agents of several viral hemorrhagic fevers; however, there are very limited countermeasures against arenavirus infections, such as vaccines or antiviral drugs, leading to consideration of global threats of pandemics. By targeting the viral glycans with sugar analogs we propose to develop a novel way to treat arenavirus infections. In this project, we will develop the antiviral compounds usable as pan- arenavirus therapy.

PI_NAMEs: PAESSLER, SLOBODAN  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Aerobic;Aerosols;Affect;Africa;alternative treatment;analog;Animals;anti-cancer therapeutic;Anti-viral Agents;Antimetabolites;Arenavirus;Arenavirus Infections;Autopsy;Binding;Biochemical;biosafety level 4 facility;Bolivian Hemorrhagic Fever Virus;Brain;Carbohydrates;Category A pathogen;Cell Culture Techniques;Cells;Chapare Virus;Chemicals;Classification;Clinical;Deoxyglucose;Dependence;design;Development;Disease;Disease Outbreaks;Dose;Drug Formulations;Drug Kinetics;Drug or chemical Tissue Distribution;Drug Targeting;efficacy study;env Gene Products;Epitopes;experimental study;Family;Fatality rate;FDA approved;Foundations;Future;Glucose;Glycolysis;Glycolysis Induction;Glycolysis Inhibition;Glycolysis Pathway;Glycoproteins;glycosylation;Goals;Heart;Hemorrhage;high risk;Human;Immune response;in vitro activity;in vivo;in vivo evaluation;innovation;insight;Intraperitoneal Injections;Isotope Labeling;Junin virus;Kidney;Lassa Fever;Lassa virus;liquid chromatography mass spectrometry;Liver;Lung;Malignant Neoplasms;Mannose;Mass Spectrum Analysis;Measures;Medical;Medicine;Metabolism;mimetics;Modeling;Molecular Mimicry;Molecular Probes;Molecular Virology;Monosaccharides;Mus;National Security;Normal Cell;novel;Organ;Oxygen;pandemic potential;particle;Pathogenicity;Pathologist;Pathway interactions;Pattern;Pharmacologic Substance;Plasma;Polysaccharides;pre-clinical;prevent;Process;Production;Proliferating;Property;Protease Inhibitor;protective efficacy;Protein Glycosylation;Proteins;prototype;Public Health;Receptor Cell;response;Risk;Route;Sabia virus;Secure;Sensorineural Hearing Loss;South American Hemorrhagic Fever;Spleen;success;sugar;Testing;Therapeutic;tissue/cell culture;Tissues;Toxicology;treatment strategy;usability;Vaccines;Venezuelan hemorrhagic fever virus;Veterinarians;Viral;Viral Hemorrhagic Fevers;Viral Physiology;Virion;Virulence Factors;Virus;Virus Diseases;Virus Inhibitors;Virus Replication

PROJECT_TITLE: Exploration of D-Glucose and D-Mannose Metabolism to Target arenaviruses

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ORG_CITY: MISSISSIPPI STATE

ORG_DEPT: CHEMISTRY

ORG_NAME: MISSISSIPPI STATE UNIVERSITY

ORG_STATE: MS

PHR: Biofilm-related infections are a significant cause of illness in the US, and many of these infections are caused by the bacterium Staphylococcus epidermidis. Biofilms are particularly important on poly-methylmethacrylate (PMMA) surfaces, which are used in many orthopedic implants, and in this project, we will characterize the molecular mechanisms by which bacteria attach to PMMA surfaces to form staphylococcal biofilms. We will also develop an anti-biofilm coating for PMMA, and we will test the effectiveness of a novel nanoparticle-based anti-biofilm treatment in an animal infection model.

PI_NAMEs: FITZKEE, NICHOLAS C (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adsorption;amidase;Amino Acids;Animal Model;Animals;Antibiotics;Autolysin;Bacteria;Bacterial Attachment Site;Basic Science;Behavior;Binding;Binding Proteins;Biocompatible Materials;biophysical analysis;Biophysics;bone;Bone Cements;Calorimetry;Cell Wall;clinically relevant;Complex;Data;Dental Implants;Development;DNA;economic impact;Effectiveness;effectiveness testing;Elastin;experimental study;extracellular;Extracellular Protein;Funding;Genus staphylococcus;Goals;Growth;hip replacement arthroplasty;Hospitals;Immune response;Immune system;Implant;implantable device;improved;In Vitro;in vivo;in vivo evaluation;Infection;innovation;Intuition;Investigation;knee replacement arthroplasty;Lead;Local Therapy;Mediating;Medical;Medical Device;medical implant;Membrane Proteins;Methicillin Resistance;Methods;Microbial Biofilms;Modeling;Molecular;Mutagenesis;nanoparticle;Nanosphere;novel;novel strategies;Orthopedics;Osteomyelitis;Patient-Focused Outcomes;photothermal therapy;physical property;Polyethylene Glycols;Polymethyl Methacrylate;polypeptide;Polysaccharides;Polystyrenes;pre-clinical research;prevent;Process;Property;Protein Engineering;Protein Region;Proteins;Research;Serum;Staphylococcus epidermidis;Structure;Study models;Surface;surface coating;Testing;Titrations;tool;Work;Wound models

PROJECT_TITLE: The Structure, Orientation, and Competitive Interactions of S. Epidermidis Biofilm Proteins on Surfaces

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Hantaviruses (e.g., the rodent-borne Sin Nombre virus and Andes virus) are bunyaviruses that cause severe human disease. No vaccines and treatments are available to prevent or treat infections caused by these agents. Here, we plan to study how these viruses hijack human proteins and pathways to multiply and cause disease.

PI_NAMEs: CHANDRAN, KARTIK  (contact)

PROJECT_TERMS: Andes Virus;Anti-viral Agents;Antibody Response;Biochemical;Biogenesis;Biological;Bunyavirales;Bypass;Case Fatality Rates;Cell Line;Cell membrane;Cells;Cellular Membrane;Client;Complex;Containment;CRISPR screen;Dependence;Development;Diagnosis;Disease;Endoplasmic Reticulum;Evaluation;Exhibits;FDA approved;gain of function;Genes;Genetic;genetic approach;Genetic Screening;genome-wide;Genomic Segment;Glycoproteins;Goals;Golgi Apparatus;Hantaan virus;Hantavirus;Hantavirus Infections;Haploidy;Human;Human Biology;human disease;infected vector rodent;Infection;Integration Host Factors;Knock-out;Knowledge;loss of function;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Proteins;Molecular Probes;mutant;Mutation;mutation screening;novel;Orthobunyavirus;Pathway interactions;Phenotype;Play;Polyproteins;prevent;Proteins;Rodent;Role;Sin Nombre virus;Testing;Therapeutic antibodies;Therapeutic Intervention;trafficking;Translation Process;transmission process;Vaccines;Variant;Viral;Virion;Virulence;Virus;virus genetics;virus host interaction;Virus Replication;Zoonoses

PROJECT_TITLE: Host-virus interactions in hantavirus glycoprotein assembly

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Microbiome;Prevention;Sepsis;Vaccine Related

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Pathogenic and antibiotic-resistant E. coli is a leading cause of worldwide morbidity and mortality. The objective of this proposal is to examine the utility of two virulence factor candidates produced by this pathogen to serve as an effective vaccine against E. coli that disseminates systemically. Encouraging pre-clinical results produced herein will provide the necessary data and experimental backdrop to evaluate testing in phased clinical trials.

PI_NAMEs: MARESSO, ANTHONY W (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Adjuvant;Antibiotic Resistance;Antibiotics;Antigens;Antimicrobial Resistance;Bacteremia;Bacteria;Bacterial Antibiotic Resistance;Biomimetics;Blocking Antibodies;Blood;Cessation of life;Chronic;Clinical;Clinical Trials;Collection;comparative genomics;Complement;cost;Cytolysins;Cytolysis;Cytotoxin;Data;Development;Disease;Dose;E. coli bacteremia;Effectiveness;Elements;emerging antimicrobial resistance;Escherichia coli;Escherichia coli Infections;Escherichia coli Vaccines;Evolution;FDA approved;Genes;Genomic approach;global health;gram-negative sepsis;Human;Human Microbiome;human mortality;Immunity;Immunologic Stimulation;Immunologics;implantable device;improved;Infection;innovation;Intestines;Invaded;Investments;Knowledge;Life;Maps;Medical;member;Microbe;microbiome;model design;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nature;Neonatal meningitis;neutralizing antibody;novel;pan-genome;pandemic disease;pathogen;Pathogenesis;pathogenic bacteria;pathogenic Escherichia coli;Pathogenicity;Performance;Persons;Phase;Phylogeny;pre-clinical;preclinical study;pressure;prevent;Process;prophylactic;Protein Secretion;Proteins;Resistance;resistance gene;Resistance to infection;Sepsis;Septic Toxemia;small molecule;Systemic disease;Systemic infection;Testing;Tissues;United States National Institutes of Health;Urinary tract infection;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccines;Virulence;Virulence Factors;Virulent;Work

PROJECT_TITLE: ExPEC Vaccine Development

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: TAMPA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Narrative Plasmodium falciparum is the major global cause of malaria morbidity and mortality and is especially devastating in pregnant women and children in sub–Saharan Africa. Mosquitoes are essential for the spread of new infections. This project will use functional genomics to identify genes needed for development of the sexual stages in the blood that infect mosquitoes.

PI_NAMEs: ADAMS, JOHN H (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Africa South of the Sahara;Anopheles Genus;asexual;bioinformatics tool;Biology;Blood;Blood Cells;Cells;Child;Clinical;Collection;Complex;Coupled;Cryopreservation;Culicidae;Data;Development;Event;experience;Fatty Acids;Female;follow-up;functional genomics;Gene Expression;gene interaction;Gene Modified;gene network;Genes;Genetic;genetic approach;Genetic Screening;Genetic Transcription;Genome;genome-wide;Genomic approach;Genomics;Genotype;graph theory;Growth;Harvest;Heat-Shock Response;Human;improved;Infection;Ingestion;interest;Libraries;Link;machine learning method;Magnetism;Malaria;male;Maps;Morbidity - disease rate;mortality;Mutagenesis;mutant;Pattern;Persons;Phase;Phenotype;Plasmodium;Plasmodium falciparum;Plasmodium genome;Population;Post-Transcriptional Regulation;posttranscriptional;Pregnant Women;Process;Proteins;Protocols documentation;Regulation;Resolution;RNA metabolism;RNA Splicing;Role;Salivary Glands;sex;sex determination;single-cell RNA sequencing;Site;Sporozoites;Time;Tissue-Specific Gene Expression;tool;Validation

PROJECT_TITLE: Discovering the Essential Genome of Plasmodium Falciparum

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Enterotoxigenic Escherichia coli (ETEC), is a leading cause of diarrhea in children under 5 years old and therefore, to avoid further morbidity and mortality due to ETEC, an efficacious vaccine given effectively is urgently required. Since children in LMICs have been difficult to effectively immunize with other oral vaccines, we propose to uncover a more effective immunization approach for protecting infants by maternal passive immunity in the first 2 years of life and beyond. We will study the protective benefits and components of ETEC specific maternal immunity from natural infection in protection of infants from ETEC infection and diarrhea.

PI_NAMEs: CHAKRABORTY, SUBHRA  (contact);GILMAN, ROBERT H

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 5 year old;Address;Adherence;Age;Antibodies;Antibody titer measurement;antibody transfer;Antigenic Diversity;Antigens;antimicrobial;Bangladeshi;Birth;Blood;Blood specimen;Child;Cholera Vaccine;Clinical Trials;Cohort Studies;cytokine;Data;design;Diarrhea;Discipline of Nursing;Enrollment;enteric infection;enterotoxigenic Escherichia coli;Epidemiological trend;Escherichia coli heat-labile toxin;Escherichia coli Infections;Escherichia coli Vaccines;Exclusive Breastfeeding;Feces;Genotype;Human Milk;Humoral Immunities;Immune response;Immunity;Immunization;Immunize;immunogenic;Immunoglobulin A;Immunoglobulin G;Inactivated Vaccines;Incidence;Infant;Infection;Influenza;Late pregnancy;Licensing;Life;low and middle-income countries;Malnutrition;Maternal antibody;maternal vaccination;Maternally-Acquired Immunity;Milk;Morbidity - disease rate;mortality;Mothers;Motility;Mucous Membrane;Natural Immunity;neonate;Newborn Infant;novel;nursing mothers;Oral;oral vaccine;Passive Immunity;Pertussis;Peru;Peruvian;Phase I/II Trial;Placenta;pregnant;Pregnant Women;prevent;Risk Reduction;Rotavirus Vaccines;Route;Serum;Symptoms;Tetanus;Toxin;Umbilical Cord Blood;vaccine immunogenicity;Vaccines

PROJECT_TITLE: Maternally acquired immunity in protection against enterotoxigenic E. coli infections in infants


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

PHR: 8. Project Narrative Staphylococcus aureus is the leading cause of skin and soft tissue infections and a major cause of devastating heart, bone, and bloodstream infections, all resulting in nearly 12 million hospital visits each year. This, combined with resistance to multiple antibiotics, emphasizes the need for new strategies to combat infection, including those that target the regulation of disease-causing factors. This proposal seeks to understand novel regulation of the SaeR/S two component system by branched-chain fatty acids and its contribution to S. aureus virulence.

PI_NAMEs: BRINSMADE, SHAUN R (contact)

PROJECT_TERMS: Affect;Amino Acids;anti-microbial peptide;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Architecture;Attenuated;Bacteria;Binding;Biochemical;Biological;branched chain fatty acid;Branched-Chain Amino Acids;Cell Death;Cells;Chemicals;Coenzyme A Ligases;combat;Complement;Complex;Development;Dimerization;Disease;DNA-Binding Proteins;Enabling Factors;Environment;Enzymes;Essential Fatty Acids;Evolution;Exhibits;experimental study;extracellular;Family;Fractionation;Gene Expression Regulation;Gene Targeting;Genetic;genetic regulatory protein;Genetic Transcription;Genus staphylococcus;Goals;Gram-Positive Bacteria;Growth;Heart;Hemolysin;Hospitals;Immune;Immune response;In Vitro;in vivo evaluation;Infection;Infectious Skin Diseases;insight;interest;Isoleucine;Keto Acids;Knowledge;Laboratories;Laboratory Study;Link;lipidomics;Liquid substance;Lysine;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Metabolism;methicillin resistant Staphylococcus aureus;Modeling;Modification;Molecular;mouse model;mutant;Names;Necrosis;novel;nuclease;Nutritional Study;Osteomyelitis;overexpression;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;Phase;Phenotype;Phospholipids;Phosphotransferases;Physiology;Polymers;posttranscriptional;prevent;Production;promoter;protein-histidine kinase;Proteins;Regulation;Reporting;Residual state;Resistance;response;Role;Route;Second Messenger Systems;segregation;sensor;sensory system;Sepsis;Shapes;Signal Transduction;Skin;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;Stimulus;System;Testing;Transcription Repressor;Variant;Virulence;Virulence Factors;virulence gene;Visit;Work

PROJECT_TITLE: Role of branched-chain fatty acids in physiology and virulence of Staphylococcus aureus

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative: Human cytomegalovirus causes a high-rate of morbidity and mortality in newborns, transplant recipients, and other immunocompromised individuals including AIDS patients, and patients with cardiovascular disease and autoimmune diseases. The development of CMV therapeutics effective therapeutics will prevent and treat cytomegalovirus-associated diseases.

PI_NAMEs: TORTORELLA, DOMENICO  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;analog;Annual Reports;Atherosclerosis;Autoimmune Diseases;Biological Assay;Body Fluids;Bone Marrow;Bone Marrow Transplantation;Cardiovascular Diseases;CD14 gene;cell type;Chemicals;Cidofovir;Collaborations;Combined Modality Therapy;Congenital Abnormality;cost estimate;Cytomegalovirus;Cytomegalovirus Infections;cytotoxicity;Data;Development;Disease;Drug Kinetics;Drug resistance;Elderly;env Gene Products;Exhibits;FDA approved;Fetus;Foscarnet;Foundations;Frequencies;Ganciclovir;gastrointestinal;Generations;Goals;Growth;heart allograft;Herpesviridae;Human;Immunocompromised Host;improved;In Vitro;in vitro Model;in vivo;indexing;Individual;Infection;inhibitor;Lead;Life Cycle Stages;maribavir;meter;Modeling;monocyte;Morbidity - disease rate;mortality;Mothers;mouse model;Mus;Neonatal Mortality;nephrotoxicity;new therapeutic target;Newborn Infant;novel;novel therapeutic intervention;novel therapeutics;operation;organ transplant recipient;Organ Transplantation;Organoids;patient population;Patients;Pharmaceutical Preparations;Phase;Physiological;Placenta;Population;Populations at Risk;prevent;Prevention;Proliferating;Property;Proteins;reactivation from latency;Reporter;SCID Mice;screening;Series;Seroprevalences;side effect;Solid;Solubility;Specificity;Structure-Activity Relationship;synergism;Testing;Therapeutic;therapeutically effective;Toxic effect;Transplant Recipients;United States;United States National Academy of Sciences;Vascular Diseases;Viral;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Optimization of novel inhibitors of human cytomegalovirus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-B(81)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Neurosciences;Prevention;Vector-Borne Diseases

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: HEALTH STATEMENT Mosquito-borne diseases such as malaria, Dengue, West Nile Fever and Yellow fever, which are transmitted to hundreds of millions of people every year, are anticipated to remain a major global health problem due to a lack of vaccines and lack of cheap, safe and broadly effective vector control methods. In this proposal, we begin with human skin-associated compounds to predict and test new repellents that act at close-range, via both olfactory and gustatory pathways, to reduce mosquito-human interactions. Such skin-derived chemicals could be developed for use in controlling the spread of mosquito-borne disease.

PI_NAMEs: DAHANUKAR, ANUPAMA ARUN;RAY, ANANDASANKAR  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;Affect;Animals;Behavior;Behavior assessment;Behavioral;Behavioral Assay;behavioral response;Biological Assay;Bite;Blood;Categories;chemical association;Chemicals;cheminformatics;Chemistry;Chemoreceptors;Complex;Cosmetics;cost;Country;Cues;Culicidae;Data;Dengue;design;Detection;disease transmission;disorder control;Electrophysiology (science);Exhibits;feeding;Female;Foundations;Genetic;global health;Goals;Health;high risk population;Human;improved;in silico;Individual;Insect Repellents;insight;Liquid substance;Machine Learning;machine learning prediction;Malaria;Measures;Methods;Microbe;microbiome;Modeling;Mosquito Control;Mosquito-borne infectious disease;mutant;Neurons;next generation;Olfactory Pathways;Pathway interactions;Persons;Play;preference;Preparation;Property;Publishing;receptor;Research;Residencies;response;Role;screening;Sensory;sensory system;Series;Signal Transduction;Skin;skin microbiome;Smell Perception;Solid;Surveys;Taste Perception;taste system;Testing;Training;transmission process;Vaccines;vector;vector control;Volatilization;West Nile Fever;Yellow Fever

PROJECT_TITLE: Olfactory and gustatory detection of aversive skin compounds by mosquitoes

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAINT LOUIS

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Stem-like T cells are proposed to orchestrate autoimmune responses, but little is known about the role of CD4+ encephalitogenic stem-like T cells. We have designed new ways to identify and characterize these cells using state-of-the-art transcriptomic signatures based on multiple genes rather than relying on the conventional single-gene approach. These new analytical tools will help develop these stem-like CD4+ T cells as novel bioindicators of MS, and the outcome of these studies will have both scientific and translational impact.

PI_NAMEs: HAWIGER, DANIEL  (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: analytical tool;Animal Model;Animals;Antigens;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Bar Codes;Biochemical;Biological Markers;Biological Process;Blood Cells;Brain;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Differentiation process;Cells;Central Nervous System;Characteristics;Consensus;Dedications;design;Development;Disease;Disease Progression;effective intervention;effector T cell;Experimental Autoimmune Encephalomyelitis;FOXP3 gene;gene conservation;Gene Deletion;Gene Expression Profile;Genes;Genetic;genetic signature;Genetic Transcription;Goals;homeodomain;Homologous Gene;Human;human disease;Immune;Immune response;Immune system;in vivo;Individual;insight;Lesion;Maintenance;Manuscripts;Modeling;Molecular Target;Monitor;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;neural;novel;Outcome;Outcome Study;Pathogenesis;Pathogenicity;Patients;Peer Review;Peripheral;Pre-Clinical Model;Process;Proteins;Publishing;Reporter Genes;Research;response;Role;Sampling;Scoring Method;single cell sequencing;stem;stem cell population;stem cells;stemness;T cell infiltration;T cell transcription factor 1;T-Lymphocyte;Testing;therapeutic target;transcriptome;transcriptomics;translational impact;tumor;Viral

PROJECT_TITLE: Stem-like T cells as bioindicators and orchestrators of the disease process in MS and animal models

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


PHR: PROJECT NARRATIVE  Transplantation is a curative therapy for organ failure in many different diseases. Although acute rejection mediated by T cells is a significant contributor to the premature failure of grafted organs, there is limited understanding of how CD8+ T cells differentiate into effector populations after grafting. Greater understanding of the signaling pathways controlling the effector CD8+ T cells that reject allografts will lead to more targeted therapeutic strategies to improve graft survival.

PI_NAMEs: KRUMMEY, SCOTT M (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acceleration;Acute;Adoptive Transfer;Allogenic;allograft rejection;Allografting;Antibody-drug conjugates;Antigens;Apoptosis;Biopsy;Calcineurin inhibitor;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cell Surface Receptors;Clinical;Clinical Research;CTLA4 gene;CTLA4-Ig;curative treatments;CXCR3 gene;Data;Disease;draining lymph node;efficacy evaluation;Epitopes;Flow Cytometry;glycosyltransferase;graft failure;graft function;Graft Rejection;Graft Survival;Granzyme;high dimensionality;Human;Immunoglobulin G;Immunologics;improved;In Vitro;in vivo;Infection;innovation;Interferon Type II;Interleukin-2;isoimmunity;Kidney;kidney allograft;Kidney Transplantation;Knock-out;Knockout Mice;Lead;Mediating;Mediator;Memory;MHC Class I Genes;Modeling;Monoclonal Antibodies;mouse model;Mus;next generation;novel therapeutic intervention;Organ failure;Organ Transplantation;Outcome;Pathway interactions;Patients;Population;premature;prevent;Proliferating;Protein Isoforms;receptor;Receptor Signaling;Resistance;response;restraint;Risk Factors;Role;Seminal;Shapes;Signal Pathway;Signal Transduction;Surface;T cell differentiation;T cell infiltration;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;Therapeutic;therapeutic target;Tissue Grafts;TNF gene;trafficking;Transplant Recipients;Transplantation

PROJECT_TITLE: Role of the CD43 Receptor on Effector CD8+ T Cells During Acute Allograft Rejection

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  The pathway of “necroptosis” refers to a form of programmed cell death associated with inflammation, but how activation of this pathway affects immune responses in vivo is not fully understood. The work proposed here will use a combination of engineered effector proteins and models of viral infection to study the immune changes induced by necroptosis.

PI_NAMEs: OBERST, ANDREW ATWELL (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: adaptive immune response;Address;Affect;Amino Acid Motifs;Apoptosis;Area;Autoimmunity;Automobile Driving;Cancer Model;Cell Death;Cell Death Induction;Cell membrane;Cell Survival;cell type;Cells;Cellular Membrane;chemokine;Cultured Cells;cytokine;Data;Development;Engineering;Epithelium;Genetic Transcription;Homeostasis;Host Defense;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunity;immunogenic cell death;Immunologics;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Influenza A virus;Innate Immune Response;Knockout Mice;Lead;Ligands;Lung;Lytic;Malignant Neoplasms;member;Modeling;Molecular;Morphology;mouse model;Mus;Nature;novel;Nucleic Acids;Output;pathogen;Pathogenicity;Pathology;Pathway interactions;Pattern;Phosphotransferases;Plasma Cells;Predisposition;prevent;Production;programs;Protein Engineering;Proteins;recruit;Research;Resistance;respiratory;response;RIPK1 gene;RIPK3 gene;Role;SARS coronavirus;Signal Pathway;Signal Transduction;Signaling Protein;small molecule;System;Testing;Therapeutic;Tissues;TLR3 gene;tool;Tumor Necrosis Factor Receptor;Viral;Virus Diseases;Work

PROJECT_TITLE: Transcriptional Outputs of the Necroptotic Pathway

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative The goals of this project are to identify neuronal mechanisms if immune regulation in the lung during inflammation.

PI_NAMEs: REARDON, COLIN  (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acetylcholine;Acute;Address;Adenylate Cyclase;Adrenal Glands;Adrenalectomy;Adrenergic Antagonists;Afferent Neurons;Agonist;Alveolar Macrophages;antagonist;Anti-Inflammatory Agents;beta-2 Adrenergic Receptors;Biological Models;Calcitonin Gene-Related Peptide;Catecholamines;Cell Physiology;Cessation of life;cholinergic;combat;Communication;cytokine;Data;Dependence;Epinephrine;experimental study;Functional disorder;Goals;Health;health determinants;Hospitals;Human;Immune;immune activation;Immune response;Immune system;immunoregulation;Infection;Inflammation;Inflammatory;Influenza;influenza infection;Injury;Innate Immune Response;innovation;Irritants;Knockout Mice;Lung;lung injury;Macrophage;Mechanical ventilation;mimetics;Molecular;Morbidity - disease rate;mortality;Mus;Nerve;nerve supply;Nervous System;Neuroimmune;Neurons;Neurotransmitter Receptor;neurotransmitter release;Norepinephrine;novel;optogenetics;Organ;pathogen;Pathogen detection;pathogenic bacteria;pathogenic virus;Pathway interactions;Pattern;pharmacologic;Physiology;Process;Production;Pulmonary Inflammation;receptor;Receptor Signaling;Reflex action;Regulation;Respiratory System;response;restraint;Role;Sensory;Signal Transduction;Source;System;T-Lymphocyte;Testing;Therapeutic;Tissues;TLR7 gene;tool;Trauma;Vagotomy;Viral;Virus

PROJECT_TITLE: Neuroimmune control of lung inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Innate immune STING signaling plays an important role in many human diseases. STING agonists are powerful new agents in cancer immunotherapy. This project will investigate the role of STING in lymphocyte development and function in normal and cancer settings.

PI_NAMEs: YAN, NAN  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adaptive immunity;anti-tumor agent;Antigen Presentation;Antitumor Response;Area;Autoimmune Diseases;Biology;cancer immunotherapy;cancer infiltrating T cells;cell type;Cells;Cellular biology;Clinical;Clinical Trials;cytokine;Data;Development;Disease;DNA Modification Methylases;effector T cell;Epigenetic Process;epigenetic regulation;Fetal Thymic Organ Culture;Funding;Genetic Models;Golgi Apparatus;Health;Homeostasis;Human;human disease;Immune;Immune signaling;Immunity;Impairment;Infection;Innate Immune System;innovation;interest;Interferons;Knowledge;Learning;Lymphocyte;Lysosomes;Malignant Neoplasms;Mammals;Mature T-Lymphocyte;Mediating;Modality;mouse model;mRNA Expression;Mus;Myeloid Cells;Natural Immunity;Nature;neuroinflammation;neuropathology;New Agents;Niemann-Pick Diseases;Output;Pathology;Pathway interactions;Pattern;Physiological;Play;Process;Proteomics;Regulation;Reporter;Research Personnel;response;Role;side effect;Signal Pathway;Signal Transduction;spatiotemporal;Stimulator of Interferon Genes;STING agonists;System;T-Cell Development;T-Lymphocyte;Testing;Thymus Gland;Time;Tissues;tool;trafficking;transcription factor;transcriptomics;Transgenic Mice;tumor;Tumor Immunity;tumor immunology;Tumor Tissue

PROJECT_TITLE: STING Signaling in Health and Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE PCDH19-clustering epilepsy (PCE) is a severe developmental and epileptic encephalopathy predominantly affecting girls and caused by pathogenic variants in an X-linked gene. Using a mouse model that we recently developed, we propose to study how this unique inheritance pattern leads to abnormal interneuron development and susceptibility to seizures. This work will provide insight into disease mechanisms and may identify a therapeutic target to treat patients with PCE.

PI_NAMEs: ZIOBRO, JULIE M (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: acquired epilepsy;Affect;Brain;career;career development;Cell Adhesion Molecules;Cell Communication;Cell Culture Techniques;Cell membrane;Cell Separation;Cells;childhood epilepsy;clinical training;clinical translation;clinically relevant;Complement;Data;design;Development;Development Plans;Developmental Therapeutics Program;Disease;Doctor of Medicine;Doctor of Philosophy;Electrophysiology (science);Epilepsy;epileptic encephalopathies;experience;Female;field study;Genes;Genetic;girls;Hippocampus;Histologic;Imaging Techniques;Impaired cognition;infancy;Inheritance Patterns;insight;Interneurons;Knowledge;Learning;Link;male;medical specialties;Mentors;Modeling;mosaic;mosaic variant;mouse model;mutant;Neurons;Neurosciences Research;Pathogenicity;Patients;Pattern;Pediatric Neurology;Physicians;Physiological;Predisposition;Process;Program Development;protocadherin 19;Research;Research Design;Research Personnel;Rodent;Scientist;Seizures;skills;Slice;Therapeutic;therapeutic target;Training;Variant;Viral Vector;Work;X Inactivation

PROJECT_TITLE: Mechanisms of PCDH19-clustering epilepsy


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PI_NAMEs: YAN, GUIYUN  (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Anopheles Genus;Biology;Biometry;Collaborations;data management;Educational workshop;Ensure;Epidemiology;Ethiopia;experience;Federal Government;Fostering;Goals;Government;Government Agencies;Group Meetings;Health;Immunology;Institution;Interdisciplinary Study;International;international center;Malaria;Monitor;Occupational activity of managing finances;outreach;Research;Research Activity;Research Personnel;Rural;Scientist;Structure;student training;success;Techniques;Time;timeline;transmission process;United States National Institutes of Health;Urbanization;vector

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: LOS ANGELES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Screening mammography has contributed to the 25-40% reduction in breast cancer mortality, but false-positive results and delays in obtaining follow-up imaging are potential harms. We propose an online interpretation, same- day diagnostic imaging paradigm, which aims to eliminate the anxiety-ridden wait times between screening and diagnostic evaluation and reduce unnecessary recalls by using an artificial intelligence solution to triage screen- ing exams. We will study whether implementing an AI algorithm at the point of care can make online reading and same-day diagnostic imaging a reality in high-volume breast screening clinics.

PI_NAMEs: HOYT, ANNE C;HSU, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Using artificial intelligence to support efficient same-day diagnostic imaging in breast cancer screening

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cachexia;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Nutrition;Rehabilitation

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE This project is relevant to public health because heart failure with reduced ejection fraction (HFrEF) is a common, chronic, progressive condition affecting at least 3 million Americans, in which the heart muscle pumps insufficient blood to meet the needs of the body. Approximately 1 in 3 patients with HFrEF develop skeletal muscle mass wasting, which has been associated with impaired physical function and decreased survival. This project seeks to understand the nutrition and metabolism abnormalities that occur during skeletal muscle wasting and to facilitate future development of new therapies that aim to both reverse muscle wasting and improve survival for patients with HFrEF.

PI_NAMEs: VEST, AMANDA RUTH (contact)

PROGRAM_OFFICER_NAME: KETEMA, FASSIL

PROJECT_TERMS: activin A;Activins;Adult;Affect;Aging;American;Antibodies;Automobile Driving;Blood;Body Weight decreased;Cancer Cachexia;Catabolism;Chronic;Clinical;clinical care;Clinical Trials;Counseling;Data;Development;Devices;Diagnosis;Dietary Proteins;Effectiveness;Eligibility Determination;Enrollment;Fatty acid glycerol esters;Fc Receptor;Follistatin;FSTL3 gene;Future;GDF15 gene;Goals;Heart Diseases;Heart failure;heart failure with reduced ejection fraction;heart metabolism;implantation;improved;Inflammatory;innovation;Intervention;Knowledge;Left;left ventricular assist device;Ligands;Literature;Medical;Metabolic;Metabolism;Molecular;mortality;Muscle;muscle form;muscle strength;Muscular Atrophy;Myocardium;N-terminal;National Heart, Lung, and Blood Institute;Natriuretic Peptides;Natural experiment;novel therapeutic intervention;novel therapeutics;nutrition;Nutritional;Nutritional Requirements;nutritional supplementation;Oral;Organ failure;Outcome;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;pharmacologic;Pharmacology;Pharmacotherapy;Phase;Physical assessment;Physical Function;physical impairment;Physical Performance;prevent;pro-brain natriuretic peptide (1-76);protein intake;Proteins;Public Health;Publishing;Pump;Randomized, Controlled Trials;receptor;Receptor Inhibition;Recovery;response;Roentgen Rays;skeletal;Skeletal Muscle;skeletal muscle wasting;Source;Supplementation;Syndrome;Testing;Therapeutic;Therapeutic Clinical Trial;Therapeutic Intervention;therapeutic target;Thinness;Translating;United States;Ventricular;Walking;wasting

PROJECT_TITLE: A SkeleTal muscle Recovery Intervention with Dietary protein in Heart Failure (ASTRID-HF)

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: AMHERST

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Despite people with schizophrenia (SCZ) facing marked tobacco-related health disparities, most smoking/vaping behavioral pharmacology studies and clinical trials exclude people with SCZ. Indeed, although withdrawal is considered a key feature of nicotine/tobacco addiction that contributes to difficulty quitting smoking and likely electronic nicotine delivery systems (ENDS; e.g., electronic cigarettes), there is currently no research on ENDS withdrawal in people with SCZ. The proposed supplement will extend the parent study’s systematic and comprehensive characterization of withdrawal (in a general population sample) to people with SCZ who vape daily compared to those who smoke daily, filling critical gaps in our understanding of ENDS dependence liability for people with SCZ and contributing to the identification of intervention targets for ENDS use.

PI_NAMEs: HAWK, LARRY W (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Abstinence;addiction liability;Address;Administrative Supplement;Agitation;Anhedonia;Antipsychotic Agents;Area;behavioral pharmacology;Cardiovascular system;cholinergic;Cigarette;cigarette smoke;Cigarette Smoker;Clinical assessments;clinical training;Clinical Trials;Cognition;Cognitive;combustible cigarette;craving;Data;Dependence;Development;Diagnosis;Disease;Disparity;effective intervention;Electronic cigarette;Electronic Nicotine Delivery Systems;electronic vape;Evaluation;Exclusion;experience;Face;Funding;General Population;Goals;Harm Reduction;health disparity;increased appetite;infancy;Intervention;Knowledge;Laboratories;Literature;Matched Group;Morbidity - disease rate;mortality;Motivation;multimodality;National Institute of Drug Abuse;negative affect;neuropsychiatric symptom;neuropsychiatry;Nicotine;Nicotine Dependence;Nicotine Withdrawal;novel;Parents;Participant;Patient Recruitments;Patient Self-Report;Persons;Pharmacology Study;polysubstance use;Population;prospective;Quasi-experiment;Randomized;recruit;Research;Sampling;Schizophrenia;Severities;sex;Sex Differences;Sleep Disorders;Smoke;Smoking;smoking abstinence;smoking cessation;Strategic Planning;System;Testing;therapy development;Tobacco;Tobacco Dependence;Tobacco smoking behavior;tool;Underrepresented Populations;vaping;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: A controlled evaluation of abstinence-induced withdrawal and motivation to vape/smoke among daily ENDS users vs. cigarette smokers


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Social Determinants of Health

PHR: This proposal is to establish the Northern Pacific Global Health Leadership, Education, And Development for Early-career Researchers (NPGH LEADERs) Consortium – a research training program directed by the University of Washington in partnership with the Universities of Hawaii, Michigan and Minnesota with international partnerships in Cameroon, Ghana, India, Kenya, Liberia, Nepal, Peru, Thailand, and Uganda. The goal of this Consortium is to provide outstanding mentored research training to U.S. and LMIC post-doctoral and U.S. pre-doctoral trainees at international partner institutions in order to create the next generation of independent global health scientists and leaders.

PI_NAMEs: DATTA, DIBYADYUTI ;JOHN, CHANDY C.;MOYER, CHERYL A.;PRASAD, SHAILENDRA ;ZUNT, JOSEPH RAYMOND (contact)

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Cameroon;career;Cost Sharing;Country;Development;Education;Educational Curriculum;Ensure;Fellowship;Funding;Ghana;global health;Grant;Hawaii;HIV;Income;India;Indiana;Kenya;Leadership;Liberia;Maps;Mentors;Michigan;Minnesota;Names;Nepal;next generation;novel;Peru;Postdoctoral Fellow;pragmatic implementation;Process;Productivity;Protocols documentation;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Scientific Inquiry;Scientist;skills;Thailand;Training;Training Activity;Uganda;Underrepresented Minority;Universities;Washington

PROJECT_TITLE: NPGH LEADERs - NCI-AIDS - Namaganda


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Neurosciences;Precision Medicine

ORG_CITY: ROUND ROCK

ORG_NAME: DELL FEDERAL SYSTEMS L.P.

PHR: No PHR

PI_NAMEs: HAMMONDODWYER, AMY K (contact);SIDDIQUI, ERUM

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Services;Training;United States National Institutes of Health

PROJECT_TITLE: NIH STRIDES - Azure and Associated Services and Training.


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Rural Health

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PI_NAMEs: BOTHNER, BRIAN P (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Address;Advisory Committees;Attention;Award;Behavioral Sciences;Biomedical Research;Brain Drains;career;career development;Collaborations;college;Communication;Communities;community engagement;Consultations;Data Collection;Data Science;Data Science Core;Development;Education;Ensure;Equity;Evaluation;Event;evidence base;experience;Face;Faculty;Faculty Recruitment;faculty support;formative assessment;Fostering;Funding;Goals;graduate student;Grant;Health;health science research;Heterogeneity;Home;Human Resources;improved;Infrastructure;Institution;Interdisciplinary Study;interest;Internships;Joints;Leadership;Learning;meetings;Monitor;Montana;Motivation;Performance;Program Evaluation;Program Research Project Grants;programs;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;Rural;Rural Community;Schedule;science education;Scientific Inquiry;Social Sciences;student training;Students;success;symposium;synergism;Teacher Professional Development;Technology;Time;Training;Translating;tribal college;tribal community;undergraduate student;Work


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PROJECT_TITLE: NPGH LEADERs - OAR Innovation Fund - Karume


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE: Nearly 40% of descendants from East Asia possess a genetic variant severely limiting their ability to metabolize reactive aldehydes. In addition, several other genetic differences in the lipid peroxidation pathway also occur in Asians which may impact organ injury, particularly during surgery. This project will develop tools in the basic science laboratory to better understand how genetic differences in the lipid peroxidation pathway may impact organ damage and translate these strategies to monitor and reduce organ damage in humans undergoing surgery.

PI_NAMEs: GROSS, ERIC RICHARD (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Aldehydes;Analgesics;Anesthesia procedures;Anesthetics;Asian Americans;Asian population;Basic Science;Biological;Biological Assay;Caring;Cause of Death;cell injury;Ethnic Origin;Far East;Functional disorder;Genetic;Genetic study;genetic variant;Health Care Costs;Human;Human Genetics;improved;insight;Knock-in Mouse;Laboratories;Lipid Peroxidation;Medical;Metabolism;Methods;Monitor;mortality;mouse model;novel;novel strategies;Operative Surgical Procedures;Organ;organ injury;Other Genetics;Pathway interactions;Persons;Phenotype;Population;precision medicine;programs;Quality of Care;Rodent;Time;tool;Translating;treatment strategy;TRP channel;United States

PROJECT_TITLE: Precision medicine for Asian Americans requiring anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: MADISON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Multiple chronic conditions (e.g., diabetes, hypertension, obesity) are a costly, pervasive problem for older adults, accounting for 90% of Medicare spending. This project will test the ability of voice-controlled "smart" technology to expand the implementation and sustain the use of a proven electronic health system (Elder Tree, or ET) for these patients; specifically, we hypothesize that older adults using ET delivered by a smart system (smart speaker plus smart display) will use and benefit from ET more than patients who access ET through a laptop because the smart system enables such easy use, even by those who have a tremor, poor vision, difficulty getting to a laptop, or other side-effects of aging. If successful, this smart system-delivered eHealth intervention will make ET more accessible and effective for older patients, improve their quality of life, and point the way to more impactful delivery of future eHealth innovations.

PI_NAMEs: GUSTAFSON, DAVID H (contact);MARES, MARIE-LOUISE

PROJECT_TITLE: AHRQ Administrative Supplement


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Cameroon;career;Cost Sharing;Country;Development;Education;Educational Curriculum;Ensure;Fellowship;Funding;Ghana;global health;Grant;Hawaii;HIV;Income;India;Indiana;Kenya;Leadership;Liberia;Maps;Mentors;Michigan;Minnesota;Names;National Institute of Environmental Health Sciences;Nepal;next generation;novel;Peru;Postdoctoral Fellow;pragmatic implementation;Process;Productivity;Protocols documentation;Publications;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resource-limited setting;Scientific Inquiry;Scientist;skills;Thailand;Training;Training Activity;Uganda;Underrepresented Minority;Universities;Washington

PROJECT_TITLE: NPGH LEADERs - NIEHS - Chuljerm


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Valley Fever

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative (Project 1 Supplement, Virulence Gene Discovery in Coccidioides) The proposed studies will lead to a molecular understanding of the virulence mechanisms utilized by Coccidioides and the varied host response to this ubiquitous fungal infection. Project 1 will use genetics and genomics to identify candidate virulence factors in the fungus.

PI_NAMEs: DANDEKAR, SATYA ;SIL, ANITA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acceleration;Affect;Area;Arizona;Biology;California;Candidate Disease Gene;candidate identification;Carbon Dioxide;Central America;Chemicals;Coccidioides;Coccidioidomycosis;cost;Development;Disease;Disease Progression;Dissection;drug discovery;drug repurposing;Drug Screening;Ensure;Event;experience;fungus;gene discovery;Genes;Genetic;genome wide association study;Genomics;Germination;Grant;Growth;Growth and Development function;Hospital Costs;Human Resources;Immune response;Immunocompetent;improved;Incidence;Incubated;Individual;Infection;Inhalation;Knock-out;Laboratories;Libraries;Lung;Molecular;mutant;Mycoses;new therapeutic target;nuclear division;Organism;parent project;pathogen;pathogenic fungus;pathogenic microbe;Pharmaceutical Preparations;Phenotype;Play;Process;Proteomics;Public Health;Reproduction spores;Resolution;Resources;Role;Rupture;Scientist;Site;Soil;Source;South America;System;Temperature;therapeutic candidate;Time;tool;trait;transcriptomics;Virulence;Virulence Factors;virulence gene;Wages

PROJECT_TITLE: Improving knockout capacity for Coccidioides


ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Project Narrative Cells require their actin cytoskeleton to divide, move, and communicate with their environment. This project will reveal novel mechanisms of how actin monomers, the basic subunit the actin cytoskeleton, control the assembly and organization of actin structures in the cell. Deciphering these fundamental mechanisms could explain why defects in monomer regulation are associated with human diseases such as neurodegeneration, inflammatory disorders, cardiac disease and cancer.

PI_NAMEs: VITRIOL, ERIC A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;Back;Behavior;Biochemical;Biochemistry;Biology;cell behavior;cell growth regulation;Cell Physiology;Cells;cellular imaging;Communication;Complex;Computer Models;Cytoskeleton;Defect;Disease;Environment;experimental study;Filament;Geometry;Heart Diseases;human disease;Image Analysis;Inflammatory;innovation;Knowledge;Malignant Neoplasms;monomer;Nerve Degeneration;novel;polymerization;Polymers;Proteins;quantitative imaging;Regulation;Role;Structure;Subgroup;superresolution imaging;tool;Work

PROJECT_TITLE: Deciphering the Mechanisms and Cellular Roles of Monomer-Driven Actin Dynamics


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative

ORG_CITY: BERKELEY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE The proposed aging center will study societal changes leading to an aging society – low fertility, longer life expectancy – as well as the effects of behavioral changes (e.g., obesity, smoking) at the level of the individual and society, and consider the adequacy of our decision making capabilities in the face of these challenges. CEDA will provide the infrastructure and support for fostering innovative research, conferences and other collaborations, and dissemination of data for analysis by researchers, policy-makers and others. Ultimately, the focus and structure will advance the development of theories and empirical data to address complex interrelationships underlying healthy aging and therefore lead to policies for improved public health.

PI_NAMEs: DOW, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Address;Adult;Advanced Development;Affect;Aging;aging demography;aging population;aging related;Applications Grants;Area;Basic Science;Behavior;behavior influence;Behavioral;behavioral and social science;behavioral economics;Behavioral Mechanisms;biodemography;Biology;causal model;Collaborations;Complex;cost;Country;Coupled;Data;Data Analyses;data dissemination;Data Set;Databases;Decision Making;Demographic Transitions;Demography;Development;Discipline;Disparate;Economic Policy;Economics;Educational workshop;Empirical Research;Epigenetic Process;Faculty;family support;Fertility;Fertilization;Fostering;Funding;Future;Genomics;Grant;Health;health determinants;Health Resources;healthy aging;High Performance Computing;Human;human mortality;improved;Individual;Influentials;Infrastructure;innovation;insight;International;Lead;Leadership;Life Cycle Stages;Life Expectancy;Measurement;Measures;Methodology;Methods;migration;Mission;model organism;Modeling;mortality;Obesity;older adult;Outcome;Pilot Projects;Policies;Policy Maker;Population;Population Analysis;population based;population health;Productivity;Public Health;Public Policy;Research;Research Personnel;Research Project Grants;Research Support;Resources;Role;San Francisco;Science;Series;Shapes;Smoking;Societies;statistics;Structure;support network;symposium;Technology;Testing;theories;Time;tool;Training Programs;Translational Research;Translations;United States;United States National Academy of Sciences;Universities;user-friendly;Vital Statistics;Work

PROJECT_TITLE: Center on the Economics and Demography of Aging


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: GANSER-PORNILLOS, BARBIE K. (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Binding;Binding Proteins;Binding Sites;Biochemical;Biochemistry;Biological Assay;Biological Metamorphosis;Capsid;CASP1 gene;Complement;Complex;Computational Technique;crosslinking and immunoprecipitation sequencing;Cryoelectron Microscopy;Cytoplasmic Tail;Data;design;Development;dimer;Disulfides;drug candidate;Drug resistance;Enzymes;experimental study;Generations;Genetic Polymorphism;genomic RNA;glycoprotein 41;Goals;HIV;HIV-1;HIV-1 integrase;imaging approach;improved;Individual;inhibitor;insight;Integrase;Integrase Inhibitors;Investigation;Knowledge;Magic;Mediating;Molecular;mutant;Mutation;novel;Nucleocapsid;particle;Pathway interactions;Peptide Hydrolases;Play;pol Gene Products;prevent;Process;Protein Inhibition;Proteins;Research Personnel;Resistance;Ribonucleoproteins;RNA;RNA-Directed DNA Polymerase;RNA-Protein Interaction;Role;Series;Site;solid state nuclear magnetic resonance;Structure;superresolution microscopy;Techniques;Testing;Variant;Viral;Viral Matrix Proteins;Viral Physiology;Viral Proteins;viral resistance;Virion;virology;Virus;Virus Replication;Visualization;Work

PROJECT_TITLE: Project 1. Maturation and Assembly


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

PI_NAMEs: AMBROSE, ZANDREA  (contact)

PROJECT_TERMS: Amino Acid Substitution;Anti-Retroviral Agents;Binding;Biochemical;Biological Assay;Capsid;Capsid Proteins;CD4 Positive T Lymphocytes;Cell membrane;cell motility;Cell Nucleus;Cells;clinically relevant;cofactor;Complement;Complex;Cryoelectron Microscopy;Cyclophilin A;Cytoplasm;Data;Dependence;Development;DNA;dynactin;Dynein ATPase;Enzymes;Genome;Goals;Guanine Nucleotide Exchange Factors;HIV;HIV-1;Immune;Immune Evasion;Immunologic Factors;Infection;inhibitor;Integration Host Factors;integration site;Kinesin;Knowledge;live cell microscopy;Macrophage;Mediating;Methods;Microtubule-Associated Proteins;Microtubules;molecular dynamics;Motor;Mutation;Mutation Analysis;novel strategies;Nuclear;Nuclear Import;Nuclear Pore Complex;Nuclear Pore Complex Proteins;particle;Pattern;Process;protein transport;Proteins;recruit;Research;Research Personnel;Resolution;Reverse Transcription;RNA;spatiotemporal;Structure;superresolution imaging;T-Lymphocyte;Therapeutic;trafficking;Travel;Tubulin;Viral;Viral Genome;Viral Packaging;Viral Proteins;virology;Virus;Virus Diseases;X-Ray Crystallography

PROJECT_TITLE: Project 2. Immune evasion, trafficking, and nuclear import


NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE  Natural products are the best source of drugs and drug leads and terpenoids, the largest family of natural products, have a wide range of clinically important activities including antibiotic, anticancer, antimalarial, and immunosuppressant properties. The proposed studies will lead to the discovery of new natural products with important biological activities, facilitate future discovery efforts by the development of systems dedicated to facile identification of terpenoids in bacteria, and result in the characterization of natural product biosynthetic enzymes. A greater understanding of terpenoid biosynthesis will also provide insights into how nature constructs medicinally relevant compounds and how these enzymes may be used as tools for future discoveries in biochemistry, bioengineering, and drug development.

PI_NAMEs: RUDOLF, JEFFREY DANIEL (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Actinobacteria class;Address;Anabolism;anti-cancer;Anti-malarials;Antibiotics;Bacteria;Bacterial natural products;Biochemistry;Bioinformatics;Biological;Biomedical Engineering;Biotechnology;Chemicals;Clinical;Collaborations;combinatorial;Complex;Cyclization;Cytochrome P450;Dedications;Development;drug development;drug discovery;Engineering;Enzymatic Biochemistry;Enzymes;experience;Family;Future;Gene Cluster;Genome;Genomics;Immunosuppressive Agents;In Vitro;in vivo;innovation;insight;interdisciplinary approach;Libraries;Medicine;metabolomics;Methodology;Mining;Natural Product Drug;Natural Products;Nature;novel;novel therapeutics;Outcomes Research;Pathway interactions;Pharmaceutical Preparations;programs;Property;Proteins;Research;small molecule;Source;Structure-Activity Relationship;success;synthetic biology;Systems Development;terpene synthase;Terpenes;Terpenoid Biosynthesis Pathway;tool;Up-Regulation;X-Ray Crystallography

PROJECT_TITLE: Discovery and Biosynthesis of Bacterial Terpenoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]