ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: OVERALL: PROJECT NARRATIVE Artificial intelligence (AI) and its associated data-driven methods are rapidly changing how we analyze biomedi- cal and behavioral datasets – but they are not at all perfect. The Bridge2AI Initiative is a transformative oppor- tunity to discover how AI can better serve everyone, realizing its potential promise to improve health and healthcare for all. Our BRIDGE Coordination Center will provide a cohesive organization across the Cores tack- ling the emergent sociotechnical issues surrounding the use of AI, working closely with the Bridge2AI Data Gen- eration Projects to ensure a successful and productive outcome for this landmark NIH initiative.

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER;BUI, ALEX  (contact);PING, PEIPEI ;WATSON, KAROL E

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Accountability;Advocate;Area;Artificial Intelligence;Behavioral;Behavioral Research;Benchmarking;biomedical informatics;Biomedical Research;Bridge to Artificial Intelligence;California;Caring;cohesion;Collaborations;Communication;Communication Methods;Communities;Data;Data Analyses;Data Collection;Data Science;Data Set;data tools;design;Development;Discipline;Disparate;Disparity population;Education;effectiveness evaluation;Electronic Health Record;Elements;Ensure;Equilibrium;Equity;Ethics;Evaluation;experience;FAIR principles;Feedback;Florida;forging;Fostering;Future;Generations;Goals;Growth;Health;health care delivery;Healthcare;Heterogeneity;Image;improved;Infrastructure;innovation;insight;Institution;interest;Leadership;Learning;Legal;Life;Life Cycle Stages;Measures;meetings;Methods;mHealth;Michigan;Mission;Morphologic artifacts;next generation;novel;Oregon;Outcome;Participant;Policies;Privacy;Process;Productivity;programs;Publishing;rapid technique;Records;Reporting;Research;responsible artificial intelligence;Science;Shapes;skill acquisition;skills;social;Source;success;Sum;synergism;Techniques;Technology;tool;tool development;Touch sensation;Training;trend;trustworthiness;United States National Institutes of Health;Universities;Vision;Work;Workforce Development

PROJECT_TITLE: Building BRIDGEs: Coordinating Standards, Diversity, and Ethics to Advance Biomedical AI


ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PI_NAMEs: BOUTROS, PAUL CHRISTOPHER (contact)

PROJECT_TERMS: Adoption;algorithm development;Algorithms;Area;Benchmarking;Bridge to Artificial Intelligence;citizen science;Communities;Computer software;Consensus Workshop;crowdsourcing;Data;Data Set;data standards;data tools;Databases;design;Development;Educational Materials;Educational workshop;Ensure;Ethics;Exercise;Fostering;Funding;Generations;Goals;Human;innovation;Learning Module;Link;member;method development;Methodology;Methods;Mission;Outcome;Registries;Resources;Services;skill acquisition;software development;Software Engineering;Standardization;support tools;Surveys;Time;tool;tool development;Training;United States National Institutes of Health;Update;Vision;Visual;web interface;Work;Workforce Development;working group

PROJECT_TITLE: Tool Core- Boutros

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-K]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Obesity is among the most pressing and costly medical challenges confronting modern society. Our recent findings suggest a novel link between systems regulating circadian rhythms and energy homeostasis. Since disruption of molecular clock genes disrupts circadian rhythms and leads to obesity and associated metabolic disorders, this work is poised to fundamentally advance our understanding of circadian control of energy balance and has the potential to identify new avenues for the prevention and treatment of obesity.

PI_NAMEs: MORTON, GREGORY J (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Area;ART protein;Behavior;Behavioral;Body Weight decreased;Calories;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Consumption;Coupled;Cues;Darkness;Development;Disease;Dorsal;Eating;energy balance;Exhibits;feeding;Feeding behaviors;Fiber;Food;gamma-Aminobutyric Acid;Genes;genetic approach;Genetic Techniques;Glutamates;Goals;Homeostasis;Human;Hypothalamic structure;in vivo;Induced Neurons;Intake;Knowledge;Leptin;leptin receptor;Lesion;Light;Link;Locomotion;Maps;Mediating;Medical Care Costs;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Modernization;molecular clock;Motor Activity;Mus;neural;neural circuit;Neurons;Neurosciences;novel;novel therapeutic intervention;Nutritional;Obesity;obesity prevention;obesity treatment;Pathway interactions;Pattern;Periodicity;Phase;Photometry;Physiological;Play;Predisposition;Prevention;Publishing;Rattus;Receptor Signaling;Regulation;Reporting;response;Rodent;Role;Running;Sensory;sensory input;Signal Transduction;Sleep;Societies;Structure of dorsomedial hypothalamic nucleus;Structure of nucleus infundibularis hypothalami;suprachiasmatic nucleus;Synapses;System;Techniques;Testing;Viral;Virus;Visceral;Visual;Work

PROJECT_TITLE: Neurocircuits that regulate circadian rhythms

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: WATSON, KAROL E (contact)

PROJECT_TERMS: Address;Adoption;algorithm development;Algorithms;Area;Artificial Intelligence;artificial intelligence method;Awareness;Behavioral;Behavioral Research;Benchmarking;biomedical data science;biomedical informatics;Bridge to Artificial Intelligence;career;career preparation;Clinical Data;Communities;complex data;Comprehension;computer scientist;Computing Methodologies;Data;data framework;Data Science;Data Set;data standards;data tools;design;Development;Dimensions;Discipline;Disparity population;Diverse Workforce;Education;education planning;education resources;Educational Activities;Educational Background;Educational Curriculum;Educational Materials;Educational process of instructing;Ensure;equity, diversity, and inclusion;Ethical Issues;ethical, legal, and social implication;Ethics;Evolution;expectation;experience;Faculty;Familiarity;Feedback;forging;Fostering;Foundations;Future;Generations;Goals;graduate student;hackathon;health care delivery;Heterogeneity;Hispanic-serving Institution;Historically Black Colleges and Universities;improved;Individual;Infrastructure;insight;Interdisciplinary Study;interest;Knowledge;Learning;Learning Module;Libraries;Link;meetings;Mentors;Mentorship;Methods;Minority Groups;Mission;Nature;novel;Outcome;outreach;Physicians;Policies;programs;Recommendation;Research;Research Personnel;Resource Development;Resource Sharing;Resources;responsible artificial intelligence;Science;Scientist;Series;Shapes;skill acquisition;skills;social;success;Techniques;theories;tool;Training;Training Activity;training opportunity;Training Programs;training project;undergraduate student;Underrepresented Minority;underserved community;Voice;Work;Workforce Development

PROJECT_TITLE: Skills and Workforce Core- Ping/Watson


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposal describes the integration of a Mendelian Genomics Research Center (MGRC) at Baylor College of Medicine in Houston Texas. It builds on past successes of rare disease research programs at Baylor, including the 9-year Baylor Hopkins Center for Mendelian Genomics, and leverages a long tradition of rare disease discovery, translational research, and basic science research that are each internationally recognized components of a collaborative research framework within the Department of Molecular and Human Genetics. We will develop a Genomic Medicine Toolbox and Comprehensive Genomics approach to study challenging rare disease cases with a goal to identify the genetic causes of human disease and seamlessly integrate these findings into clinical care.

PI_NAMEs: GIBBS, RICHARD A (contact);LUPSKI, JAMES R.;POSEY, JENNIFER ELLEN

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: advanced disease;Algorithms;Automated Annotation;Basic Science;Benchmarking;Bioinformatics;Biological Assay;Candidate Disease Gene;Clinical;clinical care;clinical diagnostics;Clinical Research;clinical research site;Code;cohort;Collaborations;college;Complex;Consent;Data;data access;Data Analyses;Data Coordinating Center;data lake;data sharing;Detection;Development;Diagnosis;Diagnostic;diagnostic accuracy;Disease;disease model;Enrollment;ethnic diversity;Etiology;exome sequencing;Family;Floor;follow-up;gene discovery;Generations;Genes;Genetic;Genome;genome sequencing;genome wide methylation;Genomic approach;genomic data;Genomic medicine;Genomics;Goals;Haploidy;high throughput screening;Human;human disease;Human Genetics;human genome sequencing;human model;improved;Individual;Infrastructure;insight;International;Knockout Mice;Laboratories;Life Cycle Stages;Link;Medical Genetics;Medicine;Mendelian disorder;Metadata;Methods;Methylation;Mitochondria;mitochondrial genome;model organism;Molecular;Molecular Diagnosis;Molecular Genetics;mosaic;Mutation;network models;novel;novel strategies;Online Mendelian Inheritance In Man;Pathogenicity;Pattern;Pediatric Hospitals;Penetrance;Phenotype;phenotypic data;precision medicine;Precision therapeutics;proband;programs;Proteins;Public Health Schools;Rare Diseases;rare mendelian disorder;Research;Research Infrastructure;screening;Short Tandem Repeat;success;Technology;Texas;therapeutic development;trait;Transcriptional Regulation;transcriptome sequencing;Translational Research;Universities;Untranslated RNA;Validation;Variant;variant of unknown significance;whole genome

PROJECT_TITLE: Baylor College of Medicine - Mendelian Genomics Research Center (BCM-MGRC)


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will build a foundational metabolic understanding of tonsils and lymph nodes, common immune organs playing a pivotal role in immunity, and their structure and functional alterations during aging. This proposal leverages cutting-edge spatial metabolite and protein profiling technology to define chemical regulators and defects in controlling a key cell type, B cell, in human tissues from diverse aged donors while simultaneously testing physiologically relevant differences between anatomically distinct T cells and B cell subtypes with unique functional changes in aging. Thus, the proposed research is relevant to the NIA’s mission of obtaining new knowledge on how the immune system is dysregulated in the elderly compared to young individuals through tissue-level molecular studies.

PI_NAMEs: COSKUN, AHMET F. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 3-Dimensional;Affinity;age group;age related;age related changes;aged;Aging;aging population;aging related;Anatomy;Antibodies;Antibody Formation;B Cell Proliferation;B-Cell Activation;B-Cell Development;B-Lymphocyte Subsets;B-Lymphocytes;Biochemical Pathway;Bioinformatics;Biomedical Engineering;Biometry;Biotechnology;CD4 Positive T Lymphocytes;Cell Aging;Cell Cycle Arrest;Cell Maturation;Cell secretion;cell type;Cells;Cellular biology;Cellular Metabolic Process;Chemicals;Cholesterol;Collaborations;Data;Defect;Deterioration;Dissociation;Elderly;Enzymes;Event;Exhibits;experience;fatty acid oxidation;Fatty Acids;Fingerprint;Genes;glucose metabolism;Goals;Helper-Inducer T-Lymphocyte;Human;human tissue;Humoral Immunities;Immune;Immune response;Immune system;Immunity;Immunoglobulin Somatic Hypermutation;Immunology;immunosenescence;Impairment;Individual;Infection;Inflammation;innovation;insight;Knowledge;lipid metabolism;Lipids;Location;Lymph Node Tissue;lymph nodes;Lymphoid Cell;lymphoid organ;Lymphoid Tissue;Maps;Measures;Memory B-Lymphocyte;Metabolic;metabolic abnormality assessment;Metabolic Control;Metabolic Pathway;Metabolism;metabolomics;Mission;Modeling;Molecular;Mutate;Neighborhoods;network models;Organ;pathogen;Pathologic;Pathway interactions;Phenotype;Phosphatidylethanolamine;Physiological;Plasma Cells;Play;Population;programs;Proliferating;protein profiling;Proteomics;Protocols documentation;Public Health;Reaction;Regulation;Research;Resolution;response;Role;secondary lymphoid organ;senescence;senescence associated secretory phenotype;small molecule;Specialized Center;Stromal Cells;Structure;Structure of germinal center of lymph node;Systems Biology;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Technology;Testing;Tissues;Tonsil;tool;Vaccines

PROJECT_TITLE: Tissue systems biology of immune dysregulation in aging by single cell spatial metabolomics

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;HIV/AIDS;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative People aging with HIV are at higher risk for Alzheimer’s disease and related dementias, and although physical activity is a promising target to mitigate such risk, this population engages in low levels of physical activity. Few studies have tested cognitive effects of exercise interventions or examined mechanisms of adherence to long-term exercise among diverse samples of midlife and older people with HIV. The current study will leverage an existing R01 to address these gaps and provide implications for development of personalized approaches for the treatment and prevention of cognitive impairment and dementia in older people with HIV.

PI_NAMEs: WHEELER, PARIYA FAZELI (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: actigraphy;Address;Adherence;Aerobic Exercise;Age;aged;Aging;Alzheimer's disease related dementia;Attenuated;Biological;Biological Markers;Black Populations;Black race;Blood;brain volume;Brain-Derived Neurotrophic Factor;cardiorespiratory fitness;Cerebrovascular Circulation;Clinical;clinical research site;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Colorado;cytokine;Dementia;dementia risk;Development;Diagnosis;Distal;Education;effectiveness evaluation;efficacy testing;Enrollment;Exercise;exercise intensity;exercise intervention;experience;Fatigue;follow up assessment;follow-up;Future;Goals;Growth Factor;Guidelines;Habits;Health;Heart Rate;high risk;HIV;Impaired cognition;Impairment;improved;Inflammatory;Interleukin-6;Interval training;Intervention;Intervention Studies;Life;Maintenance;Maximum Heart Rate;Measures;mhealth interventions;middle age;Moderate Exercise;moderate-to-vigorous physical activity;Motivation;Neurobehavioral Manifestations;neuroimaging marker;neurotrophic factor;older adult;Older Population;Outcome;Parents;personalized approach;personalized medicine;Persons;Physical activity;physical conditioning;Physical Function;Physiological;Population;Prevention;protective factors;psychologic;Race;racial disparity;racial diversity;Randomized;Recommendation;Regimen;Research Design;Rest;Risk;Sampling;Self Efficacy;sex;Site;Social support;sociodemographics;Specific qualifier value;Stimulus;text messaging intervention;Time;Training;Translating;Universities;Vascular Endothelial Growth Factors;Visit;Walking;Washington;Work

PROJECT_TITLE: Examining the Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living with HIV (HEALTH-Cog)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: This study will examine everyday driving behaviors and physiological measures obtained by in-car monitors during common driving situations (e.g., intersections, freeway ramps). The goal is to build a model that uses features from these in-car measures to detect small driving changes that may be the earliest indicators of cognitive decline and dementia in older adults. Utilizing data gathered unobtrusively from vehicles is cost effective, readily available, and may alert individuals and health care providers of early cognitive concerns, as well as potential safety issues.

PI_NAMEs: GIORDANI, BRUNO  (contact);MURPHEY, YI LU;PERSAD, CAROL C

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Arousal;Automobile Driving;Behavior;Behavior assessment;Behavioral;Brain;Brain Diseases;Breathing;Categories;Characteristics;Classification;Clinical;clinical diagnosis;Cognitive;cognitive performance;Collaborations;Collection;Complex;Consensus;cost effective;Data;Dementia;design;Detection;Development;Diagnostic;diagnostic accuracy;diagnostic platform;driving behavior;driving performance;Early Diagnosis;Enrollment;Evaluation;executive function;Expert Systems;Eye;follow-up;Funding;Galvanic Skin Response;Goals;hazard;Health Personnel;Heart Rate;Impaired cognition;implementation intervention;Individual;Language Development;late life;learning strategy;Longitudinal cohort;Machine Learning;machine learning method;Measurement;Measures;meetings;Methods;Michigan;mild cognitive impairment;Modeling;Monitor;Motor;Neurologic;Neuropsychology;novel strategies;older adult;older driver;Participant;Pattern;Performance;Personal Satisfaction;Physiological;Population;Positron-Emission Tomography;programs;psychological aspect of aging;Ramp;rate of change;recruit;Research;Research Institute;response;Safety;Sampling;Short-Term Memory;Skin Temperature;smart watch;social;Technology;Testing;Time;visual tracking;young adult;β-amyloid burden

PROJECT_TITLE: Identification of cognitive decline and dementia: Prediction by everyday driving behaviors and physiological responses


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Genetic Testing;Genetics;Health Services;Human Genome;Patient Safety;Prevention;Primary Health Care

ORG_DEPT: ADMINISTRATION

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Preventive genomic medicine, particularly identification of individuals with inherited cancer risk, can improve longevity and quality of life, yet adherence to risk management following cancer genomic testing is poor. The proposed research refines and evaluates two highly scalable population management interventions, web resources and personalized outreach, designed to improve access and use of recommended risk management following cancer genetic testing. Research activities will be conducted in a vertically integrated health system and federally qualified health center and will address post-testing quality and patient safety concerns that are minimizing patient benefit and slowing investments in real world genomic medicine implementation.

PI_NAMEs: KNERR, SARAH  (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: actionable mutation;Address;Adherence;Adopted;cancer genetics;cancer genomics;cancer risk;Caring;Case Manager;Chemoprevention;Clinical;Clinical Management;compare effectiveness;cost;Costs and Benefits;Data;Dedications;design;diabetes management;disorder risk;Education;education resources;Effectiveness;Effectiveness of Interventions;effectiveness outcome;empowerment;Ensure;Ethnic Origin;Evaluation;evidence base;Federally Qualified Health Center;follow-up;genetic risk factor;genetic testing;Genomic medicine;Genomics;Geography;Goals;Guidelines;Health;Health system;Healthcare Systems;Hereditary Malignant Neoplasm;hereditary risk;high risk;high risk population;Hybrids;implementation cost;implementation intervention;implementation outcomes;implementation process;Improve Access;improved;improved outcome;Individual;Information Systems;Infrastructure;Inherited;innovation;Integrated Health Care Systems;Intervention;Investments;Language;Link;Longevity;Malignant Neoplasms;Morbidity - disease rate;mortality;National Human Genome Research Institute;neoplasm registry;Oncogenes;online resource;Operative Surgical Procedures;outreach;patient engagement;patient outreach;patient registry;patient safety;Patients;Population;Preventive;programs;prophylactic;Provider;public health relevance;Quality of life;racial diversity;randomized trial;Recommendation;Recording of previous events;Research;Research Activity;Resources;Risk;Risk Management;Risk Reduction;Safety;screening;Screening for cancer;Screening for Ovarian Cancer;Self Management;shared decision making;socioeconomics;Strategic vision;Systems Integration;Technology;Testing;therapy design;Time;tool;Touch sensation;treatment as usual;web site;World Health

PROJECT_TITLE: Applying Population Management Best Practices to Preventive Genomic Medicine


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Disability Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative: In this study, we are targeting electrodes in a difficult-to-reach part of the somatosensory cortex with the goal of characterizing how information about the force, length and change in length of different muscles is organized in that brain area. Then we will apply stimulation to the electrode locations that encode muscle force and test if animals perceive the stimulation as an increase in their own muscle force. This technology could be used to restore arm movement sensation to paralyzed individuals or amputees who use assistive technology to move their arms.

PI_NAMEs: TAYLOR, DAWN MARIE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Activities of Daily Living;Acute;advanced system;Amputees;Anatomy;Animal Testing;Animals;antagonist;Area;arm;arm function;arm movement;Back;Behavioral;Brain;Cervical;Characteristics;Chronic;Computer software;Contralateral;Custom;Data;design;Dose;Elbow;Electrodes;Environment;Esthesia;Extensor;Feedback;Fiber;Flexor;functional electrical stimulation;Glean;Goals;Golgi Tendon Organs;Hand;Hand functions;Image;Implant;improved;Individual;Injury;Intuition;Knowledge;Learning;Length;Limb Prosthesis;Limb structure;Location;Macaca mulatta;Microelectrodes;microstimulation;Monitor;Motion;Motor;Motor Cortex;Movement;Muscle;Muscle Fatigue;Muscle Spindles;neural;Neurons;neurotransmission;novel;Operative Surgical Procedures;Paralysed;Performance;Peripheral Nerves;Persons;Population;Positioning Attribute;prevent;Primates;Process;Property;Proprioception;restoration;Rewards;Self-Help Devices;Sensory;sensory feedback;Shoulder;Signal Transduction;somatosensory;Somatosensory Cortex;Spatial Distribution;Spinal cord injury;Stimulus;System;Tactile;Technology;Testing;Time;Touch sensation;virtual;Visual;visual feedback;Wrist

PROJECT_TITLE: Targeting and Stimulating Cortical Area 3a to Restore Proprioception

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE (OVERALL PENNINGTON/LOUISIANA NORC) Obesity and the resulting metabolic consequences are major drivers for the development of type 2 diabetes mellitus and considerably increase risks for cardiovascular diseases, non-alcoholic fatty liver disease, sleep apnea, many forms of cancers and other chronic diseases. The Pennington/Louisiana Nutrition Obesity Research Center is formulated around three scientific cores that create opportunities to perform innovative research with a true potential to advance the field of “nutrition, obesity, and metabolic health through the lifespan”.

PI_NAMEs: REDMAN, LEANNE MAREE (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Affect;Animal Model;Animals;Applications Grants;bariatric surgery;base;Basic Science;bioimaging;Biological Specimen Banks;Biomedical Research;Biometry;cardiovascular disorder risk;career;Cells;Center for Translational Science Activities;Chronic Disease;Clinical;clinical application;clinical investigation;Clinical Sciences;Cognitive;Collaborations;Communication;Communities;Complement;Core Facility;cost effective;Data;data management;data repository;design;Development;Direct Costs;Discipline;Disease;energy balance;Fostering;Foundations;Functional disorder;functional genomics;Funding;Gene Expression;Glucose Clamp;Goals;Grant;Growth;Health;Human;human old age (65+);Infrastructure;innovation;Institution;Interdisciplinary Study;Intervention;Investigation;Knowledge;Laboratories;Leadership;life span;Life Style Modification;Louisiana;Malignant Neoplasms;Medical;member;Mentors;Mentorship;Metabolic;Molecular;mother nutrition;multidisciplinary;Neurons;next generation;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;Nutritional;Nutritional Science;Obesity;Obesity associated disease;obesity treatment;operation;Operative Surgical Procedures;outreach;Phenotype;Physical activity;Population;Population Sciences;Positioning Attribute;Postdoctoral Fellow;practical application;Prevalence;Prevention;Prevention strategy;programs;Publications;Regulation;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Scientist;Services;Shapes;Sleep Apnea Syndromes;Societies;synergism;Systems Integration;therapy development;Training;training opportunity;trait;Translational Research;Translations

PROJECT_TITLE: Pennington/Louisiana NORC


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TERMS: Adhesions;Animal Model;Applications Grants;base;Basic Science;Biomedical Research;Cataloging;Cells;Center for Translational Science Activities;Clinical;Clinical Sciences;Collaborations;Collection;Complex;Core Facility;Data;design;Development;Direct Costs;Disease;Doctor of Philosophy;Effectiveness;Evaluation;experience;experimental study;Faculty;Feedback;Fostering;Functional disorder;Funding;Future;Goals;Grant;Growth;Health;Human;human data;implementation process;Infrastructure;Institution;Leadership;life span;Louisiana;meetings;member;Mentors;Metabolic;Molecular;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Nutritional;Obesity;Obesity associated disease;Performance;Phenotype;Population Sciences;Positioning Attribute;practical application;Prevention;Process;process improvement;Productivity;programs;Research;Research Personnel;Resources;Services;Societies;Statistical Data Interpretation;System;Technology;Tissue Banks;Translations

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This project has strong implications for public health, particularly given the ongoing changes in legislation making cannabis more broadly available and accepted, and therefore potentially more accessible to teenagers. If age- related sensitivities to cannabis contribute to escalating use, and, moreover, if adolescents who develop cannabis use disorder (CUD) show differential change in sensitivity over time, then we will have identified key processes underlying long-term harms for teenagers who use cannabis. Supporting such scientific evidence to reduce adolescent cannabis use and the progression of CUD is important to the affected individuals and society and is a public health priority.

PI_NAMEs: TRELOAR PADOVANO, HAYLEY  (contact)

PROGRAM_OFFICER_NAME: PARIYADATH, VANI

PROJECT_TERMS: Acceleration;Accounting;Acute;Address;Adolescence;Adolescent;Affect;Age;age effect;age related;age related changes;Behavioral;biological sex;Blood Pressure;Brain;Cannabis;cannabis administration;cannabis craving;cannabis cue;Cellular Phone;Clinical;cohort;craving;cue reactivity;Cues;Data;design;Development;Dimensions;Disease;drug reward;Drug usage;DSM-V;Ecological momentary assessment;Environment;epidemiology study;Etiology;Formulation;Goals;Growth;Health;Heart Rate;Human;Hypersensitivity;incentive salience;Incubated;indexing;Individual;Individual Differences;Inhalation;innovation;Intoxication;Laboratories;Life;longitudinal design;Longitudinal Studies;marijuana use;marijuana use disorder;Measurable;Measurement;Measures;Modeling;Monitor;motivational processes;National Institute of Drug Abuse;neural;Oils;Oral;Pattern;Pharmaceutical Preparations;Physiological;pleasure;preclinical study;Predisposition;prevent;preventive intervention;Process;prospective;prospective test;Protocols documentation;Public Health;public health priorities;public health relevance;Reaction;recruit;Reporting;Research;response;Rewards;Risk;Science;Severities;Societies;Standardization;Statutes and Laws;Symptoms;System;Teenagers;Testing;theories;Time;trend

PROJECT_TITLE: Sensitivity to Cannabis Effects and Cue Reactivity as Markers of a Developing Disorder in Adolescents

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: MARTIN, CORBY K (contact)

PROJECT_TERMS: Adipose tissue;Adult;Animal Model;Area;Back;bariatric surgery;base;Behavioral;bench to bedside;biobank;Body Composition;carbohydrate metabolism;cardiorespiratory fitness;Childhood;Clinic;Clinical;Clinical Data;Clinical Research;Cognitive;Collaborations;Communities;Consultations;Data;design;Doctor of Philosophy;Eating;energy balance;Energy Metabolism;Feasibility Studies;Functional Magnetic Resonance Imaging;fundamental research;Funding;Goals;Health;Human;human subject;Image;imaging capabilities;Individual;Infant;innovation;Intervention;Laboratories;Lactation;Leadership;life span;Link;Louisiana;Measurement;meetings;member;Metabolic;Metabolism;Methods;Mission;Molecular;Muscle;Neurons;nutrition;Obesity;Phenotype;Physical activity;Pilot Projects;pragmatic trial;pregnant;Procedures;Productivity;psychologic;Publications;Quality Control;Recording of previous events;Regulation;Research;Research Methodology;Research Project Grants;research study;Research Support;Resources;Role;Scientist;sedentary lifestyle;service intervention;Services;Site;Special Population;Specialist;synergism;Tissues;Training;Training Programs;Translational Research;translational study;Translations;Woman

PROJECT_TITLE: Human Phenotyping


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Component: OVERALL PROJECT NARRATIVE Xenbase is the Xenopus model organism knowledgebase (MOK), an online resource that integrates all genomic and biological data from Xenopus research. Our mission is to accelerate the translation of Xenopus research into knowledge that will improve human health.

PI_NAMEs: VIZE, PETER D;ZORN, AARON M (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Acceleration;Aloral;Animal Model;ATAC-seq;Atlases;bioinformatics pipeline;bioinformatics tool;Biological;Biomedical Research;Cells;Cellular biology;ChIP-seq;Communities;Computer software;Consumption;Data;data exchange;data integration;data management;data mining;Data Set;data sharing;Databases;Development;Disease;disease model;DNA methylation profiling;empowerment;experience;experimental study;FAIR principles;Funding;Gene Expression;Gene Expression Process;gene regulatory network;Genes;Genomics;Genotype;Grant;Growth;Health;Human;Human Biology;human disease;human DNA;human model;improved;Infrastructure;Investments;Knowledge;knowledgebase;large scale data;Letters;Link;Mission;model organism;mutant;Names;novel;online resource;ontology development;Operating System;Output;Paper;Phenotype;phenotypic data;Play;Process;Proteomics;Publications;Publishing;relational database;repository;Research;Research Personnel;Resources;Role;Source;Technology;Time;tool;transcriptome sequencing;Translating;Translations;United States National Institutes of Health;Update;usability;user-friendly;Variant;Visualization;Visualization software;web-accessible;XCL1 gene;XenBase;Xenopus;xenopus genome

PROJECT_TITLE: Xenbase:  a Xenopus Model Organism Knowledgebase


NIH_SPENDING_CATS: Biotechnology;Data Science

PI_NAMEs: ZORN, AARON M (contact)

PROJECT_TERMS: Budgets;Canada;Communication;Communities;Development;Ensure;Goals;Infrastructure;International Aspects;knowledgebase;Leadership;member;model organism;Monitor;Occupational activity of managing finances;operation;Pediatric Hospitals;performance site;Reporting;Resources;Running;Site;software development;technology development;United States National Institutes of Health;Universities;XenBase;Xenopus

PROJECT_TITLE: Xenbase - Admin Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Immunotherapy;Prevention;Skin Cancer

ORG_DEPT: DERMATOLOGY

PHR: PROJECT NARRATIVE Ultraviolet (UV) B radiation causes suppression of immune responses, which is a major risk factor for the development of skin cancers. This proposal is based on novel findings and will apply advanced technology to study the immune mechanisms by which triggering receptor on myeloid cells 1 (Trem1) regulates UVB induced suppression of immune responses. The study will use genetic and pharmacological approaches to target Trem1 molecules for prevention and treatment of immune suppression.

PI_NAMEs: XU, HUI ;YUSUF, NABIHA  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: adaptive immunity;American Cancer Society;Animals;antagonist;Antigen-Presenting Cells;antigen-specific T cells;Beta Particle;Blood;Cancer Patient;Cancer Prognosis;carcinogenesis;CD 200;cell mediated immune response;cell type;Cells;Communicable Diseases;cost;Data;Dendritic Cells;Development;Diagnosis;Disease;draining lymph node;Environment;Epidemic;Exposure to;extracellular;Genetic;Healthcare Systems;Human;human model;Immune;Immune response;Immunosuppression;Incidence;Inflammatory;ITGAM gene;Ligands;Link;Mediating;Metals;mouse model;Mus;mutant;Myeloid Cells;neutrophil;novel;organ transplant recipient;Outcome;Pathogenesis;Peptides;Pharmaceutical Preparations;pharmacologic;Phototherapy;Population;Prevention;Prevention strategy;programmed cell death ligand 1;Public Health;Reaction;receptor;Regulatory T-Lymphocyte;Research;Risk;Risk Factors;RNA-Binding Proteins;Role;Signal Transduction;Skin;Skin Cancer;Skin Carcinogenesis;skin organogenesis;Skin tanning;Skin Tissue;Source;Sunlight;T-Cell Activation;T-Lymphocyte;Technology;Therapeutic;Time;translational potential;tumor;ultraviolet;Ultraviolet B Radiation;Ultraviolet Rays;Ultraviolet Therapy;United States;UV carcinogenesis;UV induced;UVB induced;Welding;Work

PROJECT_TITLE: Role of Trem1 in ultraviolet radiation-induced immune suppression

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Narrative The molecular mechanisms underlying the basal and activity-dependent accumulation of synaptic proteins such as CaMKII are unknown, yet the presence of these proteins is absolutely required for synaptic function. Understanding these processes will be transformative for our understanding the function of normal and diseased brains.

PI_NAMEs: GRIFFITH, LESLIE C (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3' Untranslated Regions;Acute;Address;Adult;Affect;Affinity Chromatography;Alleles;Axotomy;Behavior;Behavioral;Binding Proteins;Bioinformatics;Biological;Biological Assay;Brain;Brain Diseases;calmodulin-dependent protein kinase II;Candidate Disease Gene;cell type;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Coupled;Development;Distal;Drosophila genus;Elements;Event;experimental study;fast axonal transport;fly;Genes;Genetic;Genetic Recombination;genome editing;genomic locus;immunoreactivity;in vivo;in vivo evaluation;Individual;insight;Invertebrates;Learning;long term memory;Maps;mature animal;Memory;Messenger RNA;Metabolism;Molecular;mRNA Translation;Mus;Mushroom Bodies;mutant;Mutate;Neuromuscular Junction;Neurons;Optical Methods;Pattern;Phylogenetic Analysis;postsynaptic;Preparation;presynaptic;Process;programs;Protein Biosynthesis;Proteins;Proteome;Regulation;Regulatory Pathway;Reporter;Research;response;Rest;Ribosomes;RNA;RNA Interference;RNA-Binding Proteins;Role;Side;Specific qualifier value;Structure;Synapses;synaptic function;Synaptic plasticity;System;Testing;Time;tool;Trans-Activators;Transgenes;Translational Regulation;Translations;Vertebrates;Visualization;Work

PROJECT_TITLE: Activity-Dependent Regulation of CaMKII and Synaptic Plasticity


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Anatomy;Antibodies;Atlases;Biological;Cells;Cellular biology;ChIP-seq;Communities;Computers;Conserved Sequence;Data;data management;Data Set;Disease;disease model;diverse data;Embryo;FAIR principles;Gene Expression;Gene Expression Profile;gene function;Genes;Genome;genomic data;Goals;Human;human disease;human model;improved;indexing;innovation;International;knowledgebase;Link;Literature;Machine Learning;Maps;Metadata;model organism;mutant;Ontology;Paper;Phenotype;Procedures;Process;Proteins;Proteomics;Protocols documentation;Publications;Publishing;PubMed;Readability;Reagent;Research;Resources;RNA;Standardization;text searching;transcriptome sequencing;transcriptomics;Transgenic Organisms;Variant;Vocabulary;XenBase;Xenopus

PROJECT_TITLE: Xenbase - Curation


ORG_CITY: WASHINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative. Epilepsy is the second most common neurological disorder, but unfortunately, current treatments for epilepsy cannot control seizures in many patients. For this reason, identifying new methods and targets to control seizures is a high priority. Here we will activate a brain circuit that controls brain arousal and determine if doing so prevents seizures in several animal models, while simultaneously determining the connections in the brain that enable this circuit to stop seizures.

PI_NAMEs: FORCELLI, PATRICK ALEXANDER (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Absence Epilepsy;Acute;Affect;Animal Model;Architecture;Arousal;Attention;Basal Ganglia;Brain;brain control;Brain Stem;Cell Nucleus;Choking;cholinergic;Chronic;Corpus striatum structure;Decision Making;Deep Brain Stimulation;Electrophysiology (science);Epilepsy;Evolution;experimental study;Eye Movements;Fiber;Globus Pallidus;Glutamates;Goals;in vivo;Intervention;Intractable Epilepsy;Lead;Light;Link;Literature;locomotor control;Maps;Mediating;Medical;Methods;Midbrain structure;Modeling;Monitor;motor control;Movement;Movement Disorders;Nervous System Disorder;Neurons;Neurotransmitters;novel;optogenetics;Output;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Pharmacotherapy;Photometry;Pilocarpine;pre-clinical;prevent;Research;Resistance;Rodent Model;Role;Seizures;Site;Slice;Structure;Structure of subthalamic nucleus;Substantia nigra structure;superior colliculus Corpora quadrigemina;System;Temporal Lobe;Temporal Lobe Epilepsy;Testing;Thalamic Nuclei;Thalamic structure;Translating;United States

PROJECT_TITLE: Basal Ganglia - Brainstem Networks in the Control of Seizures

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative The goals of this project are to collect data in the 2021 wave of the Panel Study of Income Dynamics on three continuing modules—family dynamics, fertility and newborns, and education—and to design and collect a new module on immigrant assimilation, as well as to clean, document, distribute, and promote these data.

PI_NAMEs: SASTRY, NARAYAN  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adolescence;Adult;Area;Behavior;Behavioral Research;Birth;Book Chapters;Books;Charge;Child;child bearing;Child Development;Childhood;cohort;Collection;Complex;Consumption;cost effectiveness;Data;data archive;data centers;Data Collection;Data Set;Data Sources;design;Development;distributed data;economic outcome;Economics;Education;Exercise;experience;Family;Family dynamics;Family Process;Family Study;Fertility;Funding;Generations;Genetic Markers;Goals;Grant;Health;Health behavior;health disparity;Health Status;Household;Immigrant;Immigrant family;Income;innovation;intergenerational;Internet;Interview;Investments;journal article;Life;Life Cycle Stages;Life Experience;Living Arrangement;Longitudinal Surveys;Marriage;Measurement;migration;Modeling;National Institute of Child Health and Human Development;Neighborhoods;Newborn Infant;Obesity;offspring;Outcome;outreach;panel study of income dynamics;Personal Satisfaction;Policies;Population;Poverty;Process;Research;Research Personnel;response;Running;Sampling;Savings;Schools;Scientist;Shapes;Shock;Smoking;social;Social outcome;Social Sciences;Socioeconomic Status;Surveys;Teenagers;Telephone;Time;transmission process;Wages;young adult

PROJECT_TITLE: Family Dynamics, Fertility, and Investments in Children across Generations

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


PI_NAMEs: SALBAUM, J MICHAEL (contact)

PROJECT_TERMS: 3-Dimensional;Affect;analysis pipeline;Animal Model;bioimaging;Bioinformatics;Biological;Biomedical Research;career;cell type;Cells;Chromatin;Complex;Computer software;computerized data processing;Consult;cost;Counseling;Data;data archive;Data Collection;Data Set;Data Storage and Retrieval;data streams;data visualization;differential expression;driving force;epigenomics;Equipment;Etiology;experience;experimental analysis;Experimental Designs;experimental study;Expression Profiling;feature extraction;flexibility;functional genomics;Funding;Future;Gene Expression;Gene Expression Regulation;gene product;Genomic approach;Goals;Health;Human;Human Resources;human subject;image processing;imaging approach;imaging modality;Individual;instrument;instrumentation;interest;Laboratories;Leadership;life span;Light;Louisiana;Maintenance;Measures;member;Metabolic;Metabolic Diseases;Methods;Microscopy;Modernization;Molecular;Molecular Analysis;new technology;nutrition;Obesity;Outcome;Pathogenicity;Pathway Analysis;Phenotype;Physiology;Pre-Clinical Model;Procedures;protocol development;Protocols documentation;Publications;Publishing;Quality Control;quantitative imaging;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;RNA;Sampling;Services;single-cell RNA sequencing;skills;Structure;Systems Biology;Technical Expertise;Techniques;Technology;Technology Assessment;Three-Dimensional Imaging;Tissues;Training and Education;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Molecular Mechanisms


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project narrative: Type 1 diabetes is a devastating disease caused by an autoimmune process that remains incompletely understood. This proposal aims to demonstrate the ability of an engineered beta cell to resist immune rejection in a biologic model of diabetes, preventing disease onset and protecting from hyperglycemia. These studies will contribute a better understanding of autoimmunity as well as improved curative approaches for diabetes.

PI_NAMEs: CHOE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adoptive Cell Transfers;Adoptive Transfer;Affect;Allogenic;Attention;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmune Process;Autoimmunity;autoreactive T cell;autoreactivity;Beta Cell;Binding;Biological;Biological Assay;Biological Models;Biological Response Modifiers;Blood Glucose;Caring;Cause of Death;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cells;Chronic;comparative;Complex;curative treatments;cytokine;Cytoplasm;Diabetes Mellitus;diabetic;Diabetic mouse;Disease;Doxycycline;engineered beta cell;Engineering;Engraftment;Event;exhaust;Flow Cytometry;functional status;Generations;Genetic Models;glycemic control;Goals;Grant;Hyperglycemia;Iatrogenesis;Immune;Immune response;Immune system;Immunoglobulins;immunoregulation;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;Inbred NOD Mice;Incidence;Individual;Infection;Infiltration;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;ITIM;Knowledge;Laboratory Finding;Lectin;Life;Ligands;Macrophage;Malignant Neoplasms;Mediator;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Non obese;novel;novel strategies;Onset of illness;overexpression;pathogen;Phenotype;Physiological;Predisposition;prevent;Procedures;Process;Production;receptor;Replacement Therapy;Role;sialic acid binding Ig-like lectin;Sialic Acids;Sialyltransferases;Specificity;System;T-Lymphocyte;Testing;Tetracyclines;Therapeutic;Time;Tissues;transplant model;Transplantation;transplantation therapy;Tyrosine;Work

PROJECT_TITLE: ST8Sia6 modulation of diabetes


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Aloral;Amino Acids;Anatomy;ATAC-seq;Atlases;base;Bioinformatics;biomedical scientist;bisulfite sequencing;Cells;ChIP-seq;Code;Collaborations;Communities;Computer software;Consultations;Copy Number Polymorphism;Custom;Data;data access;Data Collection;data exchange;data modeling;data resource;Data Set;database query;Databases;design;Development;Disease;DNA methylation profiling;Educational workshop;empowerment;Future;genetic variant;genome resource;Genomic Segment;Goals;Grant;High-Throughput Nucleotide Sequencing;human disease;improved;Intuition;knowledgebase;Literature;Machine Learning;Maps;member;Methods;middleware;model organism;new technology;novel;Nucleotides;Phase;Phenotype;Process;Research;Resource Sharing;Resources;single cell technology;single-cell RNA sequencing;software development;Surveys;symposium;System;Technology;technology development;Testing;tool;transcriptome sequencing;Update;usability;Variant;Visualization;web app;web interface;web portal;Writing;XenBase;Xenopus

PROJECT_TITLE: Xenbase - Tech Development


PI_NAMEs: KESTERSON, ROBERT A (contact)

PROJECT_TERMS: Address;Animal Model;Animals;Area;Behavior;behavioral phenotyping;Body Composition;Categories;Comparative Biology;Consultations;CRISPR/Cas technology;Data Analyses;DNA;Energy Metabolism;Environment;Equipment;Experimental Designs;experimental study;Faculty;Feeding behaviors;flexibility;Funding;Future;Gene Expression;Gene Modified;Gene Targeting;Generations;Genes;genetic manipulation;Goals;Grant;Health;Human;human disease;in vivo;Infrastructure;innovation;Knock-in;knockout gene;Knockout Mice;life span;Louisiana;member;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Methods;Mission;Molecular;Monitor;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Nutritional Study;Obesity;obesogenic;Operative Surgical Procedures;Phase;Phenotype;Physical activity;Physical Endurance;programs;promoter;protocol development;Rattus;Research;Research Personnel;Research Project Grants;Rodent;Rodent Model;Scientist;Services;success;Techniques;Technology;Tissues;Training;Transgenic Organisms;Translational Research;United States National Institutes of Health;Viral Vector;Work

PROJECT_TITLE: Animal Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Respiratory dysfunction after spinal cord injury in the primary public health concern. The proposed study is designed to test a novel therapeutic strategy to fight this complication by using respiratory training in combination with electrical spinal cord stimulation applied epidurally in patients with chronic spinal cord injury. This knowledge will help to reduce the burden of human disability.

PI_NAMEs: OVECHKIN, ALEXANDER VLADIMIROVICH (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Activities of Daily Living;Acute;Blood Pressure;Breathing;Cardiovascular system;Chronic;Clinical;comparative;Complication;COVID-19;Data;design;Development;disability;effectiveness evaluation;Effectiveness of Interventions;Electromyography;Electrophysiology (science);Evaluation;evidence base;fighting;follow-up;functional improvement;functional outcomes;Goals;Heart Rate;Human;improved;Individual;Injury;kinematics;Knowledge;Lead;Lung;Measures;Methods;Modality;Morbidity - disease rate;mortality;Motor;motor control;Muscle;neural network;Neurologic;Neuronal Plasticity;Neurostimulation procedures of spinal cord tissue;novel therapeutic intervention;Patients;Pattern;Physiological;Population;preservation;pressure;Property;Protocols documentation;Public Health;Pulmonary function tests;Randomized Controlled Clinical Trials;rehabilitation strategy;Rehabilitation therapy;Research;Respiration;Respiration Disorders;respiratory;Respiratory Muscles;Respiratory physiology;response;restoration;Spinal;Spinal Cord;Spinal cord injury;Spinal Cord Lesions;standard of care;Surface;Testing;Therapeutic Effect;Time;Training;voltage;Work

PROJECT_TITLE: Epidural spinal cord stimulation and respiratory motor function after injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: Project Narrative Even though perceived as a less harmful alternative to conventional cigarettes, little is known about health consequences of long-term electronic cigarettes (ECs) use. We recently discovered that ECs can produce highly chemicals that may be capable of harming cells in the lung resulting in increased susceptibility to cancer development. Our proposed research will this by examining the impact of exposure of these EC chemicals on the lung in comparison with cigarette smoke in both laboratory animals and smokers. The outcomes will provide critical scientific information regarding EC oxidant exposures and inform the medical community of potential cancer-related risks of EC use.

PI_NAMEs: BITZER, ZACHARY T;FOULDS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;A/J Mouse;Activated Charcoal;Address;Adult;Aerosols;Aldehydes;analytical method;Animals;Ascorbic Acid;Behavior;Biological Markers;Blood;cancer risk;Carcinogens;Cells;Cessation of life;chemical property;Chemicals;Chronic Disease;Chronic Obstructive Pulmonary Disease;cigarette smoke;Clinical Trials;combustible cigarette;Communities;Complex Mixtures;design;Detection;Development;Devices;Disease;Dose;e-cigarette aerosols;Electron Spin Resonance Spectroscopy;Electronic cigarette;electronic cigarette use;electronic liquid;environmental tobacco smoke exposure;Exposure to;exposure to cigarette smoke;Filtration;Flavoring;Free Radicals;Funding;Glutathione;Health;Inflammation;Inflammatory;Inhalation;innovation;interdisciplinary approach;Laboratories;Laboratory Animals;Lipids;Liquid Chromatography;Lung;lung carcinogenesis;lung injury;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Measurement;Measures;Medical;method development;Methodology;Methods;Modeling;mouse model;National Institute of Drug Abuse;Nose;novel;Outcome;Oxidants;Oxidative Stress;Pathway interactions;Play;Policies;Predisposition;Reporting;Research;Resolution;response;Risk;Role;Sampling;secondary analysis;Site;Smoker;Source;specific biomarkers;Standardization;Surgeon;tandem mass spectrometry;Techniques;Testing;Time;Tissues;Tobacco;tobacco exposure;tobacco products;Tobacco smoking behavior;toxicant;Toxicology;translational approach;Urine;Variant;Youth

PROJECT_TITLE: Electronic Cigarette-derived Oxidants and their Impact on Lung Cancer Development


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE There is a growing global need for training in vaccinology and the study of vaccine-preventable diseases. To address these needs, Vanderbilt University Medical Center (VUMC), the Instituto de Investigacion Nutricional (IIN) and the Universidad Peruana Cayetano Heredia (UPCH) are joining forces to build the Peru-Vanderbilt Prevention through Vaccination Training Program (PREVENT). This new program will move IIN and UPCH toward a new horizon in the study of vaccine preventable diseases and address Peru’s need for a world-class workforce trained in vaccinology.

PI_NAMEs: GRIJALVA, CARLOS G (contact);LANATA, CLAUDIO FRANCO;OCHOA, THERESA J

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Academic Medical Centers;Address;antimicrobial resistant infection;authority;Biological;Communicable Diseases;Data;Developing Countries;Development;Disease;distrust;Doctor of Philosophy;Ensure;Evaluation;Faculty;Fellowship;Future;Goals;Grant;Growth;Herd Immunity;Immunization Programs;implementation evaluation;Knowledge;Lead;low and middle-income countries;Mentors;Modernization;multidisciplinary;Peru;Pharmacoepidemiology;pressure;Prevention;Process;Productivity;Program Evaluation;programs;Research;Research Personnel;Scientist;Structure;success;Technical Expertise;tool;Training;Training Programs;unvaccinated;Vaccination;vaccine development;vaccine trial;Vaccines;vaccinology

PROJECT_TITLE: Peru Vanderbilt – PREvention through VacciNation Training (PREVENT) program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-D(55)]


NIH_SPENDING_CATS: Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Award;Back;bioinformatics resource;Code;Communities;Complex;Computer software;computerized data processing;computing resources;Custom;Data;data exchange;Databases;diverse data;Emerging Technologies;Ensure;Environment;Genes;Genome;genome annotation;Goals;Growth;improved;Infrastructure;knowledgebase;Machine Learning;Maintenance;migration;model organism;Monitor;Performance;Privatization;Process;Publications;Reporting;Research Personnel;Resources;Running;Secure;Services;System;Testing;Time;time use;tool;Update;virtual machine;web interface;Work;XenBase;Xenopus

PROJECT_TITLE: Xenbase - Computation


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alzheimer’s disease is associated with an accumulation of repetitive RNAs that may play a role in development of the disease. The purpose of this research project is to determine if repetitive RNA accumulation in Alzheimer’s disease can be explained by age-related increases in these RNAs, and to determine if they contribute to the inflammation observed in both contexts. This work may help us understand how and why aging increases the risk for Alzheimer’s disease, and it could provide insight on potential therapeutic strategies for inhibiting these events.

PI_NAMEs: LAROCCA, THOMAS  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Adult;Age;age related;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Astrocytes;Autophagocytosis;Binding;Bioinformatics;Biological Aging;bisulfite sequencing;Brain;Cells;clinical translation;Complementary DNA;Data;Data Set;Dependence;Deposition;design;Development;Diagnostic;Disease;Double-Stranded RNA;efficacy testing;Epigenetic Process;Event;extracellular vesicles;Funding;Future;Genes;Genetic Transcription;Genome;genome wide methylation;Human;Impairment;Inflammaging;Inflammation;Inflammatory;Innate Immune Response;insight;Lead;Link;Location;Longitudinal Studies;Methylation;mild cognitive impairment;Modeling;Multiomic Data;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neurotoxic;Pathologic Processes;Pathology;Pathway interactions;Patients;Phenotype;Pilot Projects;Process;Proteins;Quality Control;Repetitive Sequence;Reporting;Research Project Grants;RNA;Sampling;sensor;Signal Transduction;Stimulator of Interferon Genes;System;systemic inflammatory response;tau Proteins;tau-1;Testing;Therapeutic;Tissues;Toxic effect;Transcript;transcriptome sequencing;whole genome;Work

PROJECT_TITLE: Age-related repetitive element dysregulation, neuroinflammation and Alzheimer's disease


PI_NAMEs: RAVUSSIN, ERIC  (contact)

PROJECT_TERMS: Application procedure;Applications Grants;Award;Biomedical Research;Botanicals;career;Centers of Research Excellence;Collaborations;Communication;cost;Direct Costs;Discipline;Eligibility Determination;Evaluation;Feedback;Felis catus;Fostering;Foundations;Funding;Goals;Grant;Health;Health Sciences;Individual;Infrastructure;innovation;Institution;Leadership;Letters;life span;Louisiana;medical schools;member;Mentors;Metabolic;Methods;Monitor;multidisciplinary;nutrition;Obesity;Philanthropic Fund;Positioning Attribute;Postdoctoral Fellow;Privatization;Process;Productivity;programs;Research;research and development;Research Personnel;Research Proposals;Resources;Running;Scientist;Secure;Senior Scientist;Sister;synergism;tool;Translational Research;translational study;United States National Institutes of Health;Work

PROJECT_TITLE: Pilot and Feasibility Program


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE: CIC-DUX4 sarcomas represent an understudied and highly lethal subset of human cancer that affects children and adolescent and young adults (AYA). The proposed research is significant to the public health as there are no effective therapies to treat CIC-DUX4 sarcomas, leading to universal death in the metastatic setting. Upon conclusion of the proposed aims, we will reveal the role of MAPK-ERK mediated degradation of CIC-DUX4 oncoproteins as a prelude to the first precision-based therapeutic strategy to target CIC-DUX4 sarcomas.

PI_NAMEs: OKIMOTO, ROSS  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Adolescent and Young Adult;Affect;Binding;Binding Sites;Biochemical;Biological;Biology;CCNE1 gene;Cell Survival;Cells;Cessation of life;Child;ChIP-seq;Chromosomal translocation;Clinical;Cytogenetics;Data;design;Development;Dissection;DNA;DUSP6 protein;effective therapy;EGF gene;ETV4 gene;EWSR1 gene;experimental study;Family member;Fusion Oncogene Proteins;Gene Expression Regulation;Genetic;Genetic study;Genetic Transcription;Goals;Homeobox;Human;Hyperactivity;improved;improved outcome;innovation;insight;Intercept;Laboratories;Ligands;live cell imaging;Malignant Neoplasms;malignant phenotype;MAPK1 gene;MAPK3 gene;Maps;Mediating;Methods;Mitogen-Activated Protein Kinases;Molecular;Molecular Abnormality;multicatalytic endopeptidase complex;Mutagenesis;Neoplasm Metastasis;neoplastic cell;Nuclear;Oncogenic;Oncoproteins;Pathway interactions;Patient-Focused Outcomes;Patients;pharmacologic;Pharmacology Study;pre-clinical;programs;Property;protein degradation;protein expression;Proteins;Public Health;Regulation;Research;Role;Sarcoma;Signal Pathway;Signal Transduction;Soft Tissue Neoplasms;Structure;survival outcome;Target Populations;Testing;Therapeutic;therapeutically effective;transcription factor;tumor;tumor growth;Tumor Promotion;Ubiquitination;Undifferentiated

PROJECT_TITLE: Therapeutic degradation of Capicua (CIC) fused oncoproteins in undifferentiated sarcomas

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Prevention;Sleep Research;Substance Misuse;Substance Misuse Prevention

ORG_DEPT: PATHOLOGY

PHR: Heavy and long-term alcohol drinking is a major cause of liver disease in the United States - sadly, there are no effective therapies. This proposal will investigate a new discovery that heavy alcohol drinking disrupts an intrinsic molecular biological oscillator or ‘clock’ in liver cells, impairing the ability of the liver to make energy needed for tissue repair and maintenance of overall liver health. The goal of this scientific research project is to increase understanding of the causes of alcohol-related liver disease with the outcome of this research having significant translational and clinical impact in terms of providing important scientific information that will accelerate new drug development to treat patients dealing with this serious liver disease.

PI_NAMEs: BAILEY, SHANNON MARIE (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acceleration;Affect;Alcohol consumption;Alcohol Hepatotoxicity;alcohol prevention;Alcohol-Induced Disorders;Alcoholic Liver Diseases;Alcohols;Area;ARNTL gene;Automobile Driving;Bioenergetics;Biological;Biological Pacemakers;Cause of Death;Chronic;chronic alcohol ingestion;Chronobiology;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;comparison control;Complex;complex IV;Consumption;cytochrome c oxidase;Data;deter alcohol use;Diet;Disease;Diurnal Rhythm;DNA Sequence Alteration;Doxycycline;drug development;drug discovery;E4BP4;effective therapy;Environmental Risk Factor;enzyme activity;Enzymes;Exhibits;extracellular;fatty acid oxidation;Functional disorder;Generations;Genes;Genetic;Genetic Transcription;Genotype;glucose metabolism;glycogen metabolism;Goals;Health;Hepatic;Hepatocyte;Histopathology;Hydrogen Peroxide;Impairment;improved;Injury;insight;Knock-out;Knowledge;lipidome;Liver;Liver diseases;liver injury;Liver Mitochondria;Maintenance;Measures;Metabolic dysfunction;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;nicotinamide-beta-riboside;novel strategies;novel therapeutics;Organ;Outcomes Research;Output;Oxidation-Reduction;Pathogenesis;Pathologic;Pathology;Patients;Periodicity;pharmacologic;Physiological;Play;pre-clinical;prevent;preventable death;Proteome;Proteomics;Reactive Oxygen Species;Research Project Grants;Resolution;Respiration;respiratory;Role;Serum;Site;small molecule;Spirometry;Stimulus;Stress;System;Testing;Tetanus Helper Peptide;Therapeutic;tissue repair;translational impact;Triglycerides;United States;Variant

PROJECT_TITLE: Circadian and mitochondrial dysfunction in alcohol-related liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: SAN DIEGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Prenatal alcohol exposure is estimated to affect 2-5% of live births in the U.S., resulting in a range of physical, neurological, and behavioral effects referred to fetal alcohol spectrum disorders (FASD). The annual meeting of the FASD Study Group provides a premier forum for discussion and collaboration among researchers focused on this serious public health problem. This grant provides support for young investigators and experts outside the field of FASD to participate in the meeting and to inform and engage efforts to better recognize, prevent and treat FASD.

PI_NAMEs: THOMAS, JENNIFER D (contact)

PROGRAM_OFFICER_NAME: JUNG, KATHY

PROJECT_TERMS: Address;Affect;alcohol research;Alcoholism;Alcohols;Applications Grants;Area;Award;Basic Science;Behavioral;Caliber;Child;Clinical;Collaborations;Communication;Data;Development;Epidemiology;Ethanol;Fees;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Development;Fostering;Funding;Goals;Grant;Group Meetings;Human;improved;Individual;interest;Investments;Live Birth;Medical;meetings;National Institute on Alcohol Abuse and Alcoholism;Neurologic;neuropathology;novel;novel strategies;Participant;Postdoctoral Fellow;prevent;Prevention;programs;Public Health;Public Policy;Request for Applications;Research;Research Personnel;scientific organization;Scientist;social;Societies;Students;symposium;Travel;United States National Institutes of Health;Update;web site

PROJECT_TITLE: Fetal Alcohol Spectrum Disorders Study Group Annual Meeting

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


PROJECT_TERMS: Acceleration;Aloral;Architecture;Bioinformatics;bioinformatics pipeline;Code;Collaborations;Communication;Communities;Controlled Vocabulary;Custom;Data;data curation;data exchange;data integration;data literacy;data management;Data Reporting;Data Set;data sharing;Databases;Disease;diverse data;EchinoBase;Echinodermata;Educational Activities;Educational Materials;Educational process of instructing;Educational workshop;European;FAIR principles;formycin triphosphate;functional genomics;Funding;genome resource;genomic data;Genomics;Goals;Health;Human;human data;improved;Infrastructure;innovation;Intuition;Knowledge;knowledgebase;Laboratories;Link;literacy;Mission;model organism;news;Ontology;outreach;Phenotype;phenotypic data;Policy Maker;Process;program dissemination;public repository;Research;Research Personnel;Resources;Source;Technology;tool;Training;Training Activity;Translational Research;United States National Institutes of Health;Universities;Variant;web app;web site;XenBase;Xenopus;xenopus genome

PROJECT_TITLE: Xenbase - Dissemination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PUBLIC HEALTH RELEVANCE: United World Antiviral Research Network (UWARN) will address emerging and re-emerging infectious diseases by carrying out research on arboviruses, viruses transmitted by arthropods to humans, with collaborating partner research laboratories in Brazil, Pakistan, Senegal, South Africa and Taiwan. The research will develop innovative new diagnostic reagents, namely human viral-neutralizing antibodies and designed proteins that release light when antibodies to virus are present in blood. UWARN research will also improve understanding of how viruses manipulate the human immune system, facilitating development of better biomarkers to predict severe disease as well as host-directed therapies that could improve outcomes of viral infection.

PI_NAMEs: GALE, MICHAEL ;RABINOWITZ, PETER MACGARR;VAN VOORHIS, WESLEY C (contact);WASSERHEIT, JUDITH N.

PROGRAM_OFFICER_NAME: WOODSON, SARA ELAINE

PROJECT_TERMS: Acute;Administrative Coordination;Alpha Virus;Animals;antagonist;Antibodies;arboviral disease;Arbovirus Infections;Arboviruses;Area;Arthropod Vectors;arthropod-borne;Bacteriology;Binding;biobank;Biological Assay;Biological Markers;Blood;Body Fluids;Brazil;candidate identification;candidate marker;Cell Separation;chikungunya;Chikungunya virus;Clinical;Clinical Management;Clinical Trials;cohort;Collaborations;Collection;Containment;Crimean Hemorrhagic Fever;cross reactivity;Data;data management;Dengue;Dengue Infection;Dengue Virus;design;Detection;Development;Diagnosis;Diagnostic;Diagnostic Reagent;Disease;Emergency Situation;Emerging Communicable Diseases;Emerging infection;emerging virus;Engineering;Enzyme-Linked Immunosorbent Assay;Epitopes;experience;Far East;Fever;Flavivirus;Fluorescence;Future;Genomic approach;global health;global health emergency;Human;human monoclonal antibodies;Immune response;Immune system;Immunoglobulin G;immunoregulation;improved;improved outcome;Individual;Infection;Infectious disease threat;Infectious Diseases Research;Innate Immune Response;Innate Immune System;innovation;Institution;International;Intervention;Investigation;Japanese Encephalitis;Knowledge;Laboratories;Laboratory Research;Light;Maps;Measurement;Metagenomics;Microcephaly;Molecular;Monitor;Monoclonal Antibodies;Natural Immunity;neutralizing antibody;neutralizing monoclonal antibodies;next generation sequencing;novel;novel diagnostics;novel strategies;Oropouche virus;Orthobunyavirus;Outcome;Pakistan;pandemic preparedness;Parasitic infection;pathogen;Pathogenesis;pathogenic virus;Pathway interactions;Patients;point of care;Population;population based;Prevalence;Process;Production;prospective;Protein Engineering;Proteins;public health relevance;Reagent;Research;Resources;Rift Valley Fever;Risk;Sampling;Senegal;Sensitivity and Specificity;Serology;Seroprevalences;severe dengue;Site;South Africa;South America;Specimen;Statistical Data Interpretation;System;Taiwan;Technology;Technology Transfer;Testing;The science of Mycology;Therapeutic;therapeutic target;Time;transcriptomics;Universities;Variant;Veterinarians;Viral;Viral Antibodies;viral detection;Viral Hemorrhagic Fevers;Viral Load result;viral transmission;Viral Vaccines;virology;Virus;Virus Diseases;Washington;Yellow Fever;ZIKA;Zika Virus

PROJECT_TITLE: University of Washington Arboviral Research Network (UWARN)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Veterinarians are trained as comparative biologists with an understanding of all living species and ideally suited to solve the complex problems presented by current and future animal and human medicine. The goal of UC Davis DVM/PhD MSTP T32 training program is to provide an outstanding environment for both clinical and biomedical research training at the nation's top-ranked School of Veterinary Medicine and to prepare our students with dual DVM-PhD degrees to become compassionate and exceptional veterinarian-scientists engaged in basic and translational research to advance the health of people and animals, in context of their changing environment.

PI_NAMEs: CHEN, XINBIN ;CUMMINGS, BETHANY PAIGE (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Doctor of Philosophy;Medical;Scientist;Training Programs

PROJECT_TITLE: UC Davis DVM/PhD Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


PI_NAMEs: KATZMARZYK, PETER TODD (contact)

PROJECT_TERMS: Awareness;Biomedical Research;career;Center for Translational Science Activities;Centers of Research Excellence;Clinical;clinical application;Clinical Nutrition;Clinical Research;Clinical Sciences;Communication;Communities;Deep South;design;Education;Educational process of instructing;Elements;Event;Faculty;Feasibility Studies;Fostering;Funding;Future;Goals;graduate student;Grant;Health;Health Professional;Impact evaluation;improved;innovation;Institution;interdisciplinary approach;Internships;life span;Louisiana;medical schools;Medical Students;member;Metabolic;Mission;Molecular;Monitor;multidisciplinary;next generation;nutrition;Nutritional;Obesity;outreach;Pilot Projects;post-doctoral training;Postdoctoral Fellow;practical application;programs;Research;Research Personnel;Research Support;Research Training;Resources;Scientist;Site;Students;Training;Training and Education;training opportunity;Training Programs;Translational Research;Translations;Travel;undergraduate student;United States National Institutes of Health;Universities;Visit;web site;webinar

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Certain change in the human brain is strongly predictive of early disease processes (such as atrophy in the case of Alzheimer’s Disease—AD). However, using conventional image processing to detect this anatomical change in clinical MR scans taken across time is difficult due to various MR effects and subject motion, which can mask the anatomical change of interest relevant to AD diagnosis and research. The aims of the proposed project are to leverage the recent advances in deep learning to design, develop and evaluate an AD imaging and analysis framework that can resolve anatomical change with high accuracy, aiding in the early diagnosis and intervention before the onset of dysfunction.

PI_NAMEs: YOUNG, SEAN ISAAC (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Accounting;Address;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Anatomy;Atrophic;Award;Biological Models;Brain;Brain imaging;Brain scan;Clinical;Clinical Data;clinical imaging;Clinical Research;Clinical Trials;Communities;Compensation;Computer software;computerized tools;Consumption;contrast imaging;cranium;Data;Data Set;deep learning;deep neural network;denoising;design;Detection;Disease;disease model;Early Diagnosis;Early Intervention;Ensure;Exposure to;Functional disorder;Goals;health care quality;Human;Image;Image Analysis;image processing;image registration;Imaging Device;imaging modality;imaging Segmentation;improved;Individual;insight;interest;Learning;longitudinal analysis;Longitudinal cohort;Magnetic Resonance Imaging;Manufacturer;Masks;Massachusetts;Methods;Modality;morphometry;Motion;MRI Scans;Nervous System Disorder;neural network;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;Neurology;Neurosciences;Noise;Phase;Physics;Process;Protocols documentation;Regional Anatomy;Relaxation;Research;Scanning;Schedule;Sensitivity and Specificity;serial imaging;Serial Magnetic Resonance Imaging;simulation;Site;skills;spatiotemporal;Structure;Study Subject;supervised learning;Supervision;Surrogate Endpoint;Time;tool;Training;Training Programs;Treatment Efficacy

PROJECT_TITLE: Ultra-precision clinical imaging and detection of Alzheimers Disease using deep learning

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Caregiving Research;Chronic Obstructive Pulmonary Disease;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Neurodegenerative;Palliative Care;Primary Health Care

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE This project is significant to public health because it will: (1) train mentees to increase the cadre of successful patient-oriented researchers who will improve care and outcomes for older adults with serious medical illness and cognitive impairment (i.e., problems with thinking and memory), and (2) generate new knowledge on how to implement early palliative care in primary care to help this patient population and their informal (family) caregivers.

PI_NAMEs: BEKELMAN, DAVID B. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Adult;Advance Care Planning;age-related disease;Aging;Alzheimer's disease related dementia;Award;Cardiology;Cardiopulmonary;care outcomes;career;career development;Caregiver support;Caregiver well-being;Caregivers;Caring;Chronic Obstructive Pulmonary Disease;Clinical;Cognition;Cognitive;cognitive function;cognitive interview;Collaborations;Colorado;comorbidity;Consolidated Framework for Implementation Research;Data;Dementia;design;Development;disability;Disadvantaged;Discipline of Nursing;Disease;Disparity population;diverse data;effectiveness study;end of life;Environment;evidence base;experience;Family;Family Caregiver;Funding;Geriatrics;Goals;Health;Heart failure;Hispanic;Impaired cognition;implementation science;improved;Individual;interest;Internist;Intervention;intervention effect;Knowledge;Medicaid;Medical;Memory;Mentors;Mentorship;Methods;mild cognitive impairment;Multi-Institutional Clinical Trial;multi-site trial;next generation;older adult;Outcome;Palliative Care;Participant;Patient Care;patient oriented;patient oriented research;patient population;Patients;Personal Satisfaction;Persons;Positioning Attribute;prevent;Primary Care;primary care patient;primary care practice;primary care setting;programs;Psychiatrist;Psychology;Public Health;Pulmonology;Quality of life;Research;Research Activity;Research Personnel;Resources;rural setting;Scientist;Screening procedure;skills;Social Work;Specialist;success;symptom treatment;Telephone Interviews;Testing;Thinking;Time;Training;United States National Institutes of Health;Universities;Visit;Work

PROJECT_TITLE: Mid-Career Mentoring Award in Palliative Care, Aging, and Cognitive Impairment

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Congenital Structural Anomalies;Digestive Diseases;Genetics;Liver Disease;Pediatric;Rare Diseases;Regenerative Medicine

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: Project Narrative Notch signaling plays countless roles in development, regeneration, and diseases, including Alagille Syndrome. However, there is currently no well-established, standard drug to activate Notch signaling for basic and biomedical studies. We have validated a new Notch agonist and propose to investigate its use for rescuing Notch signaling in animal and cell disease models as a therapeutic approach for this genetic disease.

PI_NAMEs: DONG, P. DUC SI (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: 19 year old;Adult;Age;Agonist;Alagille Syndrome;Alleles;Animal Diseases;Attenuated;Automobile Driving;autosome;bile duct;Bile fluid;Biliary;Bilirubin;Binding;Biological Assay;Birth;Body System;Cardiac;Cardiovascular system;Cell Nucleus;cell regeneration;Cells;Chlorides;Cholestasis;Data;Death Rate;Defect;Development;Dextrans;Disease;disease model;dosage;Drug Kinetics;drug standard;Duct (organ) structure;Ductal Epithelial Cell;effective therapy;efficacy evaluation;Enhancers;Extracellular Domain;Fibroblasts;Functional Regeneration;Gene Expression Profiling;Genes;Genetic;genetic approach;Genetic Diseases;Genetic Models;Genetic Transcription;Growth;Hemorrhage;Hepatic;Hepatocyte;Hepatology;Heterozygote;histological studies;Human;improved;In Vitro;in vivo;Life;Ligands;Liver;Liver Failure;liver function;Liver Regeneration;liver transplantation;Locomotion;loss of function mutation;Loss of Heterozygosity;Mammalian Cell;Modeling;mouse model;Mus;mutant;Mutation;Natural regeneration;Neonatal;notch protein;Nucleic Acid Regulatory Sequences;overexpression;Pathologic;Pathology;Patient-Focused Outcomes;Patients;Penetrance;Pharmaceutical Preparations;Phenotype;Play;postnatal;preclinical study;Prevalence;receptor;Recovery;Regimen;Role;Signal Transduction;small molecule;Testing;Therapeutic;Time;tool;Toxic effect;transcriptome sequencing;Vascular Permeabilities;Visualization;Zebrafish

PROJECT_TITLE: Augmented Notch signaling as a therapeutic approach for Alagille Syndrome

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Data Science;Hydrocephalus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Rare Diseases;Stroke

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Acute bleeding in the cerebrospinal fluid reservoir inside the brain can lead to a ballooning and pressure on normal structures in 37,000 people annually in the US. This is emergently and successfully treated with a drain that is placed through a small hole made in the skull, and carefully managed for weeks in the intensive care unit. We aim to validate automated models that can improve the challenging management of this drain, reducing infection, supporting early removal, decreasing length of stay, and improving outcomes.

PI_NAMEs: PARK, SOOJIN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: accurate diagnosis;Acute;Adopted;Adoption;Adverse event;Automated Clinical Decision Support;Blood;Brain;Brain Injuries;Caring;Case Report Form;Cerebral hemisphere hemorrhage;Cerebrospinal Fluid;Cerebrospinal fluid shunts procedure;Chronic;Classification;Clinical;Clinical Data;Clinical Decision Support Systems;clinical diagnosis;Closure by clamp;Common Data Element;Communities;cost;cranium;Dangerousness;Data;Data Science;Data Set;Decision Making;Dependence;Detection;Diagnosis;diverse data;Drainage procedure;Early Diagnosis;Electrocardiogram;Equipoise;Excision;federated learning;Frequencies;Future;Harvest;Hemorrhage;high risk;Hospital Charges;Hydrocephalus;Image;improved;improved outcome;Infection;infection risk;Institution;Intensive Care Units;Intracranial Pressure;intraventricular hemorrhage;large datasets;Length of Stay;Machine Learning;machine learning classifier;machine learning model;Measurement;Methods;model generalizability;Modeling;Morbidity - disease rate;Morphology;mortality;open data;Outcome;Output;Patients;Pattern;Persons;Physicians;Physiological;pressure;Process;prospective;prospective test;radiological imaging;Readiness;Research;Risk;Sampling;Shunt Device;Site;Structure;Subarachnoid Hemorrhage;Surveys;Testing;tool;Training;Translating;Validation;Ventricular;Weaning;Work

PROJECT_TITLE: Machine Learning to Optimize Management of Acute Hydrocephalus

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Early detection of Alzheimer’s disease and related dementias (ADRD) is paramount for prevention and treatment efforts, particularly in groups at increased risk for ADRD such as Hispanics/Latinos living in the United States. Consumer-grade mobile technologies present rich sources of data that can be collected passively in real world environments and can overcome the hurdles typically associated with traditional methods for identifying ADRD early. The proposed project will capture and analyze various streams of digital health data, passively-collected via smartphones and wrist-worn wearables, in order to identify digital signatures of ADRD risk in Hispanics/Latinos and reduce health disparities in this vulnerable and understudied segment of the U.S. population.

PI_NAMEs: MARQUINE, MARIA ;MOORE, RAEANNE CRISTINE (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acculturation;Address;Administrative Supplement;advanced disease;Age;aged;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-4;Artificial Intelligence;Behavior;Behavior assessment;Behavioral;bilingualism;Biological Markers;Blood;California;cardiovascular disorder risk;Cellular Phone;Classification;Clinical;clinical care;Cognitive;Cohort Studies;Communities;community engaged research;cost;Coupled;Data;Data Collection;dementia risk;Detection;Development;Diabetes Mellitus;Diagnosis;digital;Digital biomarker;digital data;digital health;digital phenotyping;Disparity;Early Diagnosis;Early identification;Early Intervention;Electronics;Engineering;Ensure;Environment;Environmental Risk Factor;Funding;Gait speed;handheld mobile device;Health Care Costs;health data;Health Disparities Research;Heterogeneity;Hispanic;hispanic community;Hispanic Populations;hypercholesterolemia;Hypertension;Incidence;innovation;insight;Institution;Intervention;Language;Latina Population;Latino Population;Life;Light;Link;literacy;machine learning method;machine learning model;Methods;mild cognitive impairment;mobile computing;mobile sensing;multidisciplinary;multimodality;multiple data sources;National Institute on Minority Health and Health Disparities;Neurocognitive;neurofilament;Neuropsychological Tests;Not Hispanic or Latino;novel;Obesity;Participant;Pathologic;Pathologic Processes;Persons;Physical activity;Plasma;Population;Populations at Risk;pre-clinical;Prevention;Reduce health disparities;Research;Risk;Risk Factors;Sampling;Science;secondary analysis;sensor;sex;Sex Differences;Sleep;Smoking;sociocultural determinant;Socioeconomic Status;Source;Spanish/English;Stream;Symptoms;tau-1;Technology;Test Result;Time;tool;Underserved Population;United States;Vascular Dementia;wearable device;Woman;women versus men;Work;Wrist

PROJECT_TITLE: Identifying Digital Phenotypes of Risk for Alzheimer's Disease and Related Dementias Among Hispanics/Latinos


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) are widely understood by progressive cognitive decline, yet relatively little is known about the incidence of paradoxical lucidity (PL) within ADRD, and the effect of PL on family caregivers. The proposed mixed-methods R21 will operationalize PL, while the R33 will administer a 3-wave longitudinal survey to 8,000 caregivers to assess prevalence and predictors of PL and link PL to caregiver outcomes. This work aligns with the mission of the NIA and will inform clinical practice around PL, increase the technical capacity of advocacy organizations to provide PL education, and establish a basis for epidemiological research on PL.

PI_NAMEs: GRIFFIN, JOAN M. (contact)

PROJECT_TERMS: Advocacy;advocacy organizations;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Anecdotes;Awareness;Behavior;Bereavement;Brain Health Registry;care giving burden;caregiver bereavement;caregiver interventions;Caregiver well-being;Caregivers;caregiving;Case Study;Cessation of life;Characteristics;Clinical;clinical practice;Cognitive;cognitive capacity;Communication;Conflict (Psychology);Consensus;Data;Dedications;Dementia;Dementia caregivers;demographics;Development;Dimensions;Disease;Education;Ensure;epidemiology study;Ethical Issues;Event;evidence base;experience;Family;Family Caregiver;Family member;Future;Geography;Goals;Grief reaction;Health;Impaired cognition;Incidence;Individual;innovation;Internet;Intervention;Interview;Knowledge;Link;Long-Term Care;longitudinal analysis;Longitudinal Surveys;Measures;Memory;Methodology;Methods;Minnesota;Mission;Moods;Nonprofit Organizations;novel;Outcome;Outcome Study;Pattern;perceived stress;Persons;Pharmaceutical Preparations;Phase;Prevalence;Prognosis;psychoeducation;Registries;Reporting;Research;Resources;response;sex;Structure;Surveys;Testing;Time;Typology;Universities;Work

PROJECT_TITLE: Definition and Caregiver Appraisal of Paradoxical Lucidity in Dementia


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Kidney Disease

PHR: Project Narrative  Alterations in organ oxygenation contribute to the high prevalence of kidney, brain, and heart injuries that accompany major surgery. The effects of oxygen tension on mechanisms of organ injury are poorly understood, and oxygen administration during surgery is highly variable, unguided, and potentially harmful. We are investigating the impact of different oxygen tensions on mechanisms of perioperative organ injury in order to develop novel treatments to reduce organ injury and improve patient outcomes.

PI_NAMEs: BILLINGS, FREDERIC TREMAINE (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Arteries;arteriole;biobank;Blood Vessels;Brain Injuries;Cells;Cessation of life;circulating biomarkers;Clinical Trials;Collaborations;Complement;experience;experimental study;Functional disorder;Genetic Transcription;Genetically Engineered Mouse;Heart Atrium;Heart Injuries;Heme;Heme Group;Hemoglobin;High Prevalence;human tissue;Hyperoxia;Hypoxia;Hypoxia Inducible Factor;improved;Injury to Kidney;Investigation;Laboratories;laboratory experiment;Lead;lung injury;Measurement;Measures;Mediating;Molecular;Molecular Target;Morbidity - disease rate;multimodality;Mus;Myocardium;National Institute of General Medical Sciences;normoxia;novel;novel therapeutics;Operative Surgical Procedures;Organ;organ injury;oxidation;oxidative damage;oxidized lipid;Oxygen;Oxygen Therapy Care;Pathway interactions;Patient-Focused Outcomes;Patients;Perioperative;Perioperative complication;Plasma Cells;Postoperative Period;Pre-Clinical Model;programs;Prospective, cohort study;Proteins;Research;response;Sampling;Signal Transduction;Soluble Guanylate Cyclase;therapeutic target;therapy development;Tissue Model;Tissues;Transcript;transcriptome;translational approach;Vascular Smooth Muscle

PROJECT_TITLE: Oxygen and perioperative organ injury

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Despite the widespread acceptance that evidence-based treatments exist for alcohol use disorder (AUD), only one in nine individuals with AUD report receiving specialty treatment. The Certified Community Behavioral Health Clinic (CCBHC) Medicaid demonstration required clinics to provide nine services chosen to improve access and integration; to provide data on quality metrics; and to engage in prospective reimbursement. This project examines the effects of the CCBHC program on AUD identification, treatment receipt and quality and whether the CCBHC program led to improvements in public health outcomes.

PI_NAMEs: BUSCH, SUSAN H (contact)

PROGRAM_OFFICER_NAME: WHITAKER, DAMIYA EVE

PROJECT_TERMS: Acute;addiction;Adult;alcohol involvement;alcohol use disorder;Award;behavioral health;black patient;Black race;Caring;Certification;Chronic;Clinic;Clinical;Communities;Complex;cost;Cost Savings;County;COVID-19;Crime;Data;design;evidence base;Evidence based treatment;flexibility;Grant;Health;health disparity populations;Health Services;Health system;Hispanic;Improve Access;improved;Incentives;Individual;Information Systems;information technology workforce;Infrastructure;Interdisciplinary Health Team;interest;intimate partner violence;Investments;Low income;Medicaid;Medical;medical specialties;Mental Health;Methodology;Modeling;neighborhood disadvantage;Outcome;Outpatients;pandemic disease;Patient-Focused Outcomes;Patients;payment;Performance;Physicians;Policies;policy implication;preventable death;Primary Care;programs;Prospective Payment System;Provider;Public Health;public health emergency;Quasi-experiment;Recovery;Reimbursement Mechanisms;Reporting;Research;Research Personnel;Resources;Savings;screening;service delivery;Services;societal costs;Substance Use Disorder;Surgeon;System;Telemedicine;Traffic accidents;Training;treatment and outcome;treatment services;United States Centers for Medicare and Medicaid Services;United States National Institutes of Health;vehicular accident

PROJECT_TITLE: Alternative payment models and alcohol use disorder treatment and consequences

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness;Tourette Syndrome

PHR: NARRATIVE Tic disorders and obsessive-compulsive disorder are commonly comorbid and are thought to have overlapping pathophysiology in the cortico-basal ganglia circuitry. Work in an animal model of pathophysiology and pilot data in subjects with tics and OCD have identified previously uncharacterized abnormalities in dopamine D2 and D3 receptors. We will use state-of-the-art positron emission tomography (PET) imaging to examine these receptors in vivo in the brains of individuals with tics, OCD, or both; this will characterize these systems in tic disorders and OCD for the first time and has the potential to elucidate targets for novel treatments, and to identify the particular patients who might benefit from them.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Address;Adult;Agonist;Alleles;Anhedonia;Animal Model;antagonist;Basal Ganglia;Behavior;Behavioral;Binding;Brain;Categories;Characteristics;Chronic;Clinical;clinically significant;comorbidity;Comparative Study;compulsion;Corpus striatum structure;Data;Data Set;Development;Diagnosis;Diagnostic;Disease;Dissociation;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;Drug Targeting;Functional disorder;Ganglia;Genes;Genetic;genetic architecture;Genetic study;Gilles de la Tourette syndrome;Globus Pallidus;Histidine Decarboxylase;Human;Image;imaging study;in vivo;independent component analysis;Individual;individualized medicine;insight;Intervention;Knockout Mice;Knowledge;Ligands;Measures;Methodology;Modeling;Morbidity - disease rate;mouse model;Mus;Mutation;Nature;neurochemistry;neuroeconomics;neuropsychiatric disorder;neuropsychiatry;Nonsense Mutation;novel;Nucleus Accumbens;Obsession;Obsessive-Compulsive Disorder;Patients;Pattern;Penetrance;Positron-Emission Tomography;putamen;Raclopride;receptor;receptor binding;recruit;response;reward processing;Severities;Signal Transduction;Structure;Substantia nigra structure;symptomatology;Symptoms;Syndrome;System;Testing;Thalamic structure;Tic disorder;tic related;Time;Tracer;Translations;Up-Regulation;Ventral Striatum;Work

PROJECT_TITLE: Dysregulation of dopamine receptors in the basal ganglia in OCD and tic disorders: Positron Emission Tomography with [11C]-PHNO

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]