NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sexually Transmitted Infections

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Chlamydia pneumoniae, an agent of human respiratory disease, relies on specialized mechanisms that exert anti-host activities essential to pathogenesis. Understanding those mechanisms requires a tractable means of genetic manipulation. This proposal contains work designed to develop mutagenesis and expression techniques for C. pneumoniae that will be important for the study of disease.

PI_NAMEs: FIELDS, KENNETH A (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acceleration;Acute;Address;Alleles;Biology;Bronchitis;Cell Separation;cell type;Cells;Cellular biology;Chlamydia;Chlamydia trachomatis;Chlamydial pneumonia;Chlamydophila pneumoniae;chronic infection;Communities;community acquired pneumonia;Comparative Study;Complement;constitutive expression;Data;design;Development;Disease;Ectopic Expression;efficacy testing;Endocytosis;Engineering;Epithelial Cells;Epitopes;Exhibits;expression vector;Filopodia;Foundations;Future;Gene Deletion;Gene Duplication;Gene Expression;gene product;Genes;Genetic;genetic manipulation;Genetic Techniques;Genitalia;High Prevalence;Human;human pathogen;inducible gene expression;Infection;Inflammatory;intracellular parasitism;Invaded;Light;Maintenance;Mediating;member;Molecular;Mucous Membrane;Mutagenesis;mutant;new technology;novel strategies;obligate intracellular parasite;pathogen;Pathogenesis;Pathogenicity;Phagocytes;Phenotype;Plasmids;Prevalence;Probability;Process;protein function;Proteins;receptor mediated endocytosis;recruit;Recruitment Activity;Research;Respiratory Disease;respiratory pathogen;Respiratory Tract Infections;Reverse engineering;Role;seropositive;Sinusitis;sorting nexins;System;Techniques;Technology;tissue tropism;trafficking;vector;Work

PROJECT_TITLE: Addressing genetic tractability and species-specific infection biology in Chlamydia pneumoniae

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

PHR: This application requests funding to support the Autumn Immunology Conference, an annual gathering of scientists (primarily from the midwestern US) that is designed to facilitate the dissemination of new research results, to establish or strengthen collaborations between laboratories, and to serve as a platform for the development of young trainees in the field of immunology. Research in immunology is important for the public health mission of NIH and greatly impacts our ability to understand autoimmunity and allergy, to design effective vaccines to prevent infectious diseases, and to improve cancer immunotherapy regimens.

PI_NAMEs: D'ORAZIO, SARAH E. F. (contact)

PROGRAM_OFFICER_NAME: BARTELS, ADELINA EWURA-ABENA

PROJECT_TERMS: Address;Anniversary;Area;Autoimmune Diseases;Autoimmunity;Automobile Driving;Award;Beer;cancer immunotherapy;career;career development;Cheese;Chicago;Coffee;Collaborations;Communicable Diseases;Communication;Consultations;COVID-19 pandemic;Data;Dedications;design;Destinations;Development;Doctor of Philosophy;Education;Educational workshop;Equilibrium;equity, diversity, and inclusion;Event;experience;Faculty;Fees;Female;Fostering;Funding;Gender;graduate student;Home;Hypersensitivity;Immunologics;Immunologist;Immunology;improved;Institution;interest;International;Laboratories;Leadership;Learning;male;Malignant Neoplasms;meetings;member;Midwestern United States;Mission;National Institute of Allergy and Infectious Disease;Nature;new technology;Positioning Attribute;Postdoctoral Fellow;posters;prevent;Process;programs;Public Health;recruit;Regimen;Request for Applications;Request for Proposals;Research;Research Personnel;Role;Rotation;Scientist;Services;skills;Structure;Students;symposium;T-Cell Development;Therapeutic;Transplantation;Travel;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Vaccines;Visit;volunteer;Volunteer Group;Wine;Work

PROJECT_TITLE: Autumn Immunology Conference


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: PATHOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The current SARS-CoV-2 pandemic has demonstrated that bat zoonoses can have wide ranging and devastating impacts on human health and society, and although we have long acknowledged that bats present a weak point for zoonotic spillover due to their ability to harbor many viruses without pathogenic consequence, progress towards understanding their unique immunology has lagged due to a lack of tools to study their immune system. Here we propose a project that will develop two valuable technologies that will help elucidate bat immunology, with the first investigating the impact of bat sequence diversity on key innate immune molecules, and the second identifying previously unknown bat specific resistance factors that inhibit RNA virus replication. By both developing the biotechnological tools and using them to gain scientific insight, this application will draw a blueprint that other scientists can follow to further understand bat immunity and its relationship with potentially zoonotic viruses, which is critical for reaching the level of knowledge needed to prevent future pandemic zoonoses from bats.

PI_NAMEs: BRUCHEZ, ANNA  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;Address;Amino Acids;Animals;base;Biological;Biotechnology;causal variant;Cell Line;Cells;cellular engineering;Cessation of life;Characteristics;Chimera organism;Chiroptera;Complement;COVID-19 pandemic;Cytoplasm;Development;DNA biosynthesis;Ebola virus;Exposure to;functional genomics;Future;future pandemic;Genes;Genetic;Genetic Determinism;genome-wide;Glycoproteins;Goals;Health;Homeostasis;Homologous Protein;Human;Immune;Immune system;Immunity;Immunologics;Immunology;improved;Individual;Infection;innate immune mechanisms;innate immune pathways;insight;Interferons;Investigation;Knowledge;Learning;Lemurs;Libraries;Link;Mammals;Metabolic;Methodology;Methods;Modernization;Molecular;Mutagenesis;Mutagens;mutation screening;Natural Immunity;new technology;Nipah Virus;Nucleic Acids;Orthologous Gene;Pathogenicity;Pathway interactions;Phosphorylation;prevent;Proteins;Proxy;Rabies virus;Recombinant DNA;Regulation;Resistance;resistance factors;resistance gene;RNA;RNA Virus Infections;RNA Viruses;Rodent;Role;Scientist;Signal Transduction;Site;Societies;Technology;technology/technique;Temperature;Testing;tool;trait;Vesicular stomatitis Indiana virus;Viral Physiology;Virus;Virus Replication;whole genome;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Functional genomic characterization of diverse bat innate immune mechanisms


NIH_SPENDING_CATS: Asthma;Childhood Obesity;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BRONX

ORG_DEPT: PEDIATRICS

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE Obesity-related asthma is the most consistently reported type of pediatric non-allergic asthma. It is a major subset of pediatric asthma, that is increasing in incidence, since 20% of children in the U.S. are overweight/obese, and is associated with high disease burden that is poorly responsive to asthma medications. Having found links between decreased RPS27L gene expression and lung function deficits found in obese children with asthma, we plan to investigate the mechanisms by which RPS27L contributes to pediatric obesity-related asthma.

PI_NAMEs: RASTOGI, DEEPA  (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Actins;Adipose tissue;Adolescent;African;African American;Albuterol;Alleles;Asthma;biobank;Biological;Biology;burden of illness;Cell Cycle;Cell Differentiation process;cell motility;Cell Physiology;Cell Proliferation;Cells;Child;Childhood;Childhood Asthma;cohort;CXCL10 gene;CXCR3 gene;cytokine;Disease;Down-Regulation;effective therapy;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genotype;Health;healthy weight;Helper-Inducer T-Lymphocyte;Hispanic;Hispanic Americans;Immune response;Immunobiology;Incidence;Inhalation;Interferon Type II;Investigation;Latinx;Light;Link;Mediating;migration;Minor;Minority;minority children;Nature;new therapeutic target;novel;Obesity;obesity in children;obesity risk;obesity-associated asthma;Overweight;Pathogenesis;Pathway interactions;peripheral blood;Pharmaceutical Preparations;Phenotype;Play;polarized cell;polymerization;Polymers;Population;Positioning Attribute;preadolescence;Predisposition;Primary Prevention;programs;Proliferating;protein phosphatase inhibitor-2;Proteins;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Quantitative Trait Loci;recruit;Reporting;Research;respiratory smooth muscle;rho GTP-Binding Proteins;Ribosomal Proteins;Risk Factors;Risk Marker;risk variant;Role;Sampling;Single Nucleotide Polymorphism;Small Interfering RNA;Steroids;targeted treatment;Testing;Th1 Cells;Therapeutic Intervention;TNF gene;tumor;Up-Regulation;Weight Gain

PROJECT_TITLE: Relevance of RPS27L expression quantitative trait locus in pediatric obesity-related asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE  To date there is no easy and affordable human Plasmodium falciparum malaria transmission model that would enable a variety of transmission studies. We will develop a standardized, affordable and accessible human malaria infection model, thereby closing a critical gap in malaria transmission studies.

PI_NAMEs: DIMOPOULOS, GEORGE  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Achievement;Advanced Development;Anopheles Genus;asexual;Biological Assay;Biology;Blood;Communities;Culicidae;Development;drug development;Falciparum Malaria;feeding;Human;humanized mouse;In Vitro;Infection;Laboratories;Malaria;malaria infection;malaria transmission;Membrane;Methodology;Methods;Modeling;mouse model;Mus;novel;Parasites;Parasitology;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;pre-clinical;Publishing;Recovery;repository;Rodent Model;Standardization;Techniques;Transgenic Organisms;transmission blocking;transmission process;transmission-blocking vaccine;vaccine development;vector;vector mosquito

PROJECT_TITLE: Complete Plasmodium falciparum infection cycle model

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Microbiome

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARATIVE Humans are colonized with a large number of microorganisms, collectively known as the microbiota that provide numerous key functions. We find, during early life, these microbes are trafficked to the thymus where T cells that recognize them then expand. We will investigate the role of intestine, microbiota, immune cells, and thymus in this expansion.

PI_NAMEs: BETTINI, MATTHEW  (contact);DIEHL, GRETCHEN E

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adult;Affinity;Age;age related;antigen-specific T cells;Antigens;Asthma;Autoantigens;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;CD8-Positive T-Lymphocytes;cell motility;Cell Physiology;Cells;Characteristics;Chronic;Communities;Cues;Data;Dendritic Cells;Dermatitis;Development;Disease;early life exposure;Education;effector T cell;Ensure;Environment;Epithelial Cells;Equilibrium;Exposure to;fighting;FOXP3 gene;gut microbes;gut microbiota;Human;Hypersensitivity;Immune;immune function;Immune system;Immunity;in vivo Model;Infection;Inflammatory;Inflammatory Bowel Diseases;intestinal epithelium;Intestines;Life;Microbe;microbial;microbial products;microbiome;microbiota;microbiota composition;microorganism;microorganism antigen;migration;Modeling;Molecular;Mucous Membrane;Mus;novel;Nutrient;Organ;pathogen;Pathology;Pathway interactions;Peripheral;Play;Predisposition;Process;Publishing;Regulation;Regulatory T-Lymphocyte;response;Role;Self Tolerance;Series;Shapes;Signal Induction;Signal Transduction;System;T-Cell Development;T-Lymphocyte;Thymocyte Development;Thymus Gland;thymus transplantation;Time;Tissues;trafficking;Work

PROJECT_TITLE: Early life regulation of microbiota specific thymic T cell development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-K(57)]


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Women's Health Research

ORG_DEPT: BIOLOGY

PHR: Group B Streptococcus is an important pathobiont that causes life-threatening infections in neonates, the elderly and the immunocompromised adults. The proposed studies will determine how the Type VII Secretion System contributes to the interbacterial antagonism and how it contributes to the colonization and infection processes.

PI_NAMEs: KOROTKOV, KONSTANTIN V (contact);PATRAS, KATY

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Abscess;Adherence;Adult;antagonist;anti-toxin;Antibiotic Prophylaxis;Antibiotic Resistance;Bacteria;Bacterial Infections;Biochemical;Bioreactors;Blood - brain barrier anatomy;Cell Line;Cells;clinically relevant;Communities;Complex;Core Protein;Cytolysis;cytotoxicity;Development;Disease;Ecosystem;Elderly;Enterococcus faecalis;Epithelium;experimental study;Family;female reproductive tract;Firmicutes;Foundations;Future;Gastrointestinal tract structure;Gene Cluster;genetic approach;Genome;genomic locus;Goals;Gram-Positive Bacteria;Group B Streptococcus colonization;gut microbiome;Hand;Human;human microbiota;Immune response;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Invaded;Life;Measures;Mediating;member;Meningitis;Microbe;microbiome components;microbiota;microorganism;Molecular;Mothers;mouse model;Mucous Membrane;Mus;neonatal infection;neonate;Newborn Infant;Nutrient;Organism;Outcome;pathobiont;pathogen;Pathway interactions;Pelvis;Play;Pneumonia;Pregnant Women;prevent;Preventive measure;Process;Proteins;Research Design;Role;Route;Sepsis;Shapes;Solid;Staphylococcus aureus;Streptococcal Infections;Streptococcus;Streptococcus Group B;Streptococcus intermedius;Surface;System;Testing;Time;Toxic effect;Toxin;translational model;transmission process;uptake;Urinary tract;Urinary tract infection;Vagina;vaginal microbiome;vaginal microbiota;Vertical Disease Transmission;Virulence

PROJECT_TITLE: Function of the type 7 secretion system in Group B Streptococcus


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because providing a mechanistic view on the role of lipogly- cans in mycobacterial cell envelope integrity is a step toward developing chemotherapeutic strategies against mycobacterial diseases. The proposed research is expected to provide fundamental knowledge in evolutionarily conserved aspects of cell envelope biogenesis in mycobacteria, likely revealing vulnerabilities in the process as a potential drug target in line with NIH’s mission to provide therapeutic strategies against tuberculosis and other mycobacterial diseases.

PI_NAMEs: MORITA, YASU S (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TITLE: Cell envelope integrity in mycobacteria: interplay of lipoglycans, peptidoglycan, and capsular polysaccharides


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative This study aims to develop and evaluate a hydrology-based malaria transmission and risk model, and then apply the model to identify malaria hotspots and water management strategies. Our research findings will facilitate malaria prevention and control through targeted vector control in transmission hotspots and through the use of optimal water management strategies that meet the needs of crop production but reduce vector habitats and malaria transmission

PI_NAMEs: HSU, KUO-LIN ;YAN, GUIYUN  (contact)

PROJECT_TERMS: Africa;African;Agriculture;Architecture;Area;Behavior;Bite;Breeding;Calibration;Clinical;Country;Coupled;Culicidae;Data;Databases;Detection;Development;Ecology;Effectiveness;Entomology;Environmental Engineering technology;Environmental Impact;Environmental Risk Factor;Epidemic;epidemiologic data;Epidemiology;Ethiopia;Geographic Locations;Geography;Government;Habitats;hydrology;improved;Incidence;Insecticide Resistance;Insecticides;Investigation;Irrigation;Kenya;Location;Malaria;Malaria prevention;malaria transmission;Maps;Methods;Modeling;Modification;Nature;novel;Outcome;parallel computer;Performance;physical process;Prevalence;Process;Production;programs;prospective;Public Health;Recommendation;Regulation;remote sensing;Research;Research Project Grants;Research Support;Residual state;Resolution;Risk;risk prediction;scale up;simulation;Site;Source;success;Surface;Surveys;Testing;tool;transmission process;United States National Institutes of Health;vector;vector control;Vector Ecology;Water;World Health Organization

PROJECT_TITLE: A Novel Hydrology-based Malaria Transmission Model and Field Applications


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Clinical Research;Dental, Oral, and Craniofacial Disease;Endocannabinoid System Research;Neurosciences;Nutrition;Obesity;Prevention;Therapeutic Cannabinoid Research

ORG_CITY: PISCATAWAY

ORG_DEPT: NUTRITION

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Public Health Relevance Statement / Project Narrative Long chain fatty acids (LCFAs) in the mouth generate an intestinal endocannabinoid response, which signals that a calorie-rich triglyceride meal is being consumed, which reinforces further intake. In Western society, with fatty, palatable foods on every corner, the stimulation of gut endocannabinoid production is chronically sustained, and fat intake is chronically reinforced, leading to weight gain and concomitant changes in oral LCFA detection and signaling. These oral sensitivity changes likely contribute to increased fat intake, very much like how decreased sensitivity to salt and sugar are correlated with greater salt and sugar intake, and so we will study how adiposity and the endocannabinoid system influence fat taste and consumption.

PI_NAMEs: BRESLIN, PAUL A. S (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: 2-arachidonylglycerol;anandamide;antagonist;Attenuated;Body fat;Brain;Calories;Cannabidiol;CD36 gene;Cells;Chronic;CNR1 gene;Consumption;Data;Desire for food;Detection;diet-induced obesity;Disease;Dose;Eating;Elements;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Energy Intake;Essential Fatty Acids;Evaluation;experimental study;Fatty acid glycerol esters;Fatty Acids;Food;food craving;food environment;Growth and Development function;Health;hedonic;Human;Ice Cream;insight;Intake;Intestines;Lipids;long chain fatty acid;Measurement;Metabolism;Mild obesity;moderate obesity;Moods;Motivation;Mus;Neurophysiology - biologic function;Nonesterified Fatty Acids;Nutrient;Obese Mice;obese person;Obesity;Omega-6 Fatty Acids;Oral;Oral cavity;Participant;Perception;Physiology;Plasma;preference;Process;Production;Psychology;public health relevance;receptor;Regulation;response;Rewards;Rodent Model;Role;Saturated Fatty Acids;Signal Transduction;Societies;Sodium;Sodium Chloride;sugar;System;Taste Perception;taste system;Testing;therapeutic target;Thinness;Tissues;trend;Triglycerides;Weight;Weight Gain;Work

PROJECT_TITLE: Regulation of Fat Taste by Adiposity and Endocannabinoids: Implications for Obesity

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the clinical application of variable-activity powered prosthetic legs can significantly improve community mobility and therefore quality of life for nearly a million Americans with lower-limb loss. Emerging powered prostheses are limited to a small set of pre-defined activities, which does not allow continuous variations of steady-state activities (e.g., walking at different speeds/inclines) or continuous transitions between activities (e.g., walking to stair ascent). This project will model and control joint biomechanics over continuously-varying activities for the design of agile, powered prostheses that require little to no tuning, which aligns with the missions of the Devices and Technology Development program area of the NICHD National Center for Medical Rehabilitation Research.

PI_NAMEs: GREGG, ROBERT D (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: active control;Adoption;American;Amputees;Ankle;ankle prosthesis;Area;Artificial Leg;Biological;Biomechanics;Biomimetics;Clinic;Clinical;clinical application;clinically significant;Communities;Custom;Data;design;Device or Instrument Development;Doctor of Philosophy;electric impedance;Engineering;Environment;Equilibrium;experience;Gait;Goals;Human;human model;improved;Individual;innovation;Intuition;joint biomechanics;Joint Prosthesis;Joints;kinematics;Knee;Knee Prosthesis;Lead;Life;limb loss;Locomotion;Lower Extremity;Machine Learning;Manufacturer;Measurable;Mechanics;Medical center;Methods;Michigan;Mission;Modeling;Motion;Motor;motor control;multidisciplinary;National Institute of Child Health and Human Development;novel;Orthotic Devices;Outcome;Patient-Focused Outcomes;Phase;powered prosthesis;Process;Program Development;Prosthesis;prosthesis control;Prosthesis Design;Public Health;Qualifying;Quality of life;rehabilitation research;Research;response;robot control;Speed;System;Technology;technology development;Time;Torque;United States National Institutes of Health;Universities;Variant;Viscosity;Walking;Work

PROJECT_TITLE: Controlling Locomotion over Continuously Varying Activities for Agile Powered Prosthetic Legs

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Depression;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Serious Mental Illness;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Approximately 50% of women with bipolar disorder discontinue their antipsychotic medication during pregnancy due to concerns for the fetus but this approach might put these women at high risk for relapse, which can have severe consequences. The proposed studies will investigate the risks and benefits of antipsychotic use during pregnancy using large and comprehensive Danish and Swedish population-based registers and will help to answer whether continuation or discontinuation of antipsychotics will present the least risk to both mothers and their offspring.

PI_NAMEs: BERGINK, VEERLE  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: active comparator;Age;anti-depressive agents;Antipsychotic Agents;Benefits and Risks;Bipolar Disorder;bipolar patients;bipolar spectrum;Birth Weight;Child;Clinical Research;Conceptions;Control Groups;Data;Denmark;Disease;early pregnancy;Exposure to;Family;Fathers;Fetal Development;Fetus;follow-up;Gestational Age;Health;health of the mother;high risk;High Risk Woman;Hospitalization;in utero;Infanticide;Inpatients;Knowledge;lamotrigine;Lithium;Long-Term Effects;Maternal Health;maternal morbidity;Maternal Mortality;Mental Health;Meta-Analysis;Metabolic;Metabolic Diseases;Monitor;Mood Disorders;Mothers;Neonatal;neonatal outcome;novel;offspring;Outcome;Patients;Perinatal;perinatal period;perinatal women;Pharmaceutical Preparations;Population;population based;Postpartum Period;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;prevent;Recurrence;Relapse;relapse prevention;relapse risk;Resources;Risk;Sample Size;Siblings;Source;suicidal risk;Suicide;Suicide attempt;Sweden;Titrations;Unipolar Depression;Weight Gain;Woman

PROJECT_TITLE: Relapse after Discontinuation of Antipsychotics during Pregnancy (R-DAP study)

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabidiol Research;Cannabinoid Research;Drug Abuse (NIDA only);Natural Products;Neurosciences;Pediatric;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: UNIVERSITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE Pre-, peri- and postnatal exposures to ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are increasing with expanded use of marijuana, hemp-derived supplements, and minor cannabinoid- containing products available and marketed directly to consumers for an array of health claims. This project will address knowledge gaps associated with developmental consequences of exposure to THC, CBD, and other minor cannabinoids, with a particular emphasis on determining how early life exposures contribute to acute and latent effects into adulthood. Our long-term goal is to define critical periods of susceptibility, the dose dependence of adverse outcomes, and molecular mechanisms of action of cannabinoids that can be used to guide cannabis/CBD policy decisions and ensure public health safety.

PI_NAMEs: ASHPOLE, NICOLE M;WILLETT, KRISTINE L (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Adolescence;Adolescent;Adult;Adverse effects;adverse outcome;Anxiety;Behavior;Behavior Disorders;Behavioral;behavioral outcome;Biological Models;Brain;Cannabidiol;cannabigerol;cannabinoid dependence;cannabinoid receptor;Cannabinoids;Cannabis;Centers of Research Excellence;Child;Childhood;CNR1 gene;CNR2 gene;Collaborations;Confocal Microscopy;Consumption;Core Facility;critical period;Decision Making;Defect;Deformity;Dependence;Development;developmental toxicity;Disease;Dose;early life exposure;Embryo;Ensure;exposed human population;Exposure to;Fetus;Fishes;Funding;Future;Gene Expression;Genes;Genetic Transcription;glial activation;Goals;Growth and Development function;Gynecologist;Health;Healthcare;Hemp;human old age (65+);illicit drug use;in vivo;Infiltration;Inflammation Mediators;Inflammatory;insight;Knock-out;Knowledge;Life;liquid chromatography mass spectrometry;Locomotion;Marijuana;marijuana use;Marketing;Measurement;Measures;Mediating;Minor;Modeling;Molecular;Molecular Mechanisms of Action;Morning Sickness;Morphology;National Institute of Drug Abuse;neuroinflammation;Neurons;Organism;Pathway interactions;pediatrician;Perception;Perinatal;Policies;Policy Maker;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal;Productivity;protein expression;Proteins;Proteomics;Public Health;Publications;receptor expression;Recommendation;Relaxation;reproductive toxicity;Research;Research Support;response;Safety;sex;single nucleus RNA-sequencing;Sleeplessness;Stress;Tetrahydrocannabinol;Time;Toxic effect;Transgenic Organisms;United States National Institutes of Health;Validation;vaping;Work;Zebrafish

PROJECT_TITLE: Vulnerability and Persistence of Neuroinflammation and Behavioral Deficits from Developmental Cannabinoid Exposure

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Kidney Disease;Prevention

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Wildfire-derived fine particulate matter (PM2.5) pollution is a growing public health concern worldwide, but epidemiologic information is limited regarding how the increasing pollution affects individuals with or at risk of chronic kidney disease (CKD), a large population extremely vulnerable to natural disasters including wildfire smoke. More accurate exposure estimates are necessary to support more reliable epidemiologic analysis of wildfire PM2.5. This proposal will develop novel statistical methods to improve the estimation of wildfire PM2.5 exposure, based on which to provide crucial new insights into the concentration-response relationships between wildfire PM2.5 exposure and its adverse effects on vulnerable kidney disease populations.

PI_NAMEs: BI, JIANZHAO  (contact)

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute;Adult;advanced analytics;Adverse effects;Affect;Age;Air Pollution;analytical method;Big Data Methods;career;career development;Cessation of life;chemical resource;Chemicals;Chronic;Chronic Kidney Failure;climate change;clinically significant;comorbidity;computerized data processing;computing resources;cost;Data;Data Analyses;Databases;demographics;Development;Diabetes Mellitus;Dialysis procedure;Diameter;Disasters;disorder risk;Dose;Education;electronic health data;Emergency department visit;End stage renal failure;Environmental Epidemiology;Environmental Exposure;Epidemiology;epidemiology study;Ethnic Origin;Event;Exposure to;fine particles;Fire - disasters;Frequencies;global health;Glomerular Filtration Rate;Guidelines;Health;Health Care Costs;Hemodialysis;Hospitalization;Hypertension;improved;Individual;Information Systems;innovation;Inpatients;insight;Instruction;Kidney;Kidney Diseases;Knowledge;Long-Term Effects;machine learning algorithm;Measures;Medical;Mentors;Mentorship;meter;Methods;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;Natural Disasters;nephrotoxicity;non-compliance;novel;Obesity;Outpatients;Particulate Matter;Patients;Phase;Policies;Pollution;Population;predictive modeling;Predisposition;Prevalence;Public Health;Race;Recording of previous events;Records;Registries;Renal function;Research;Resolution;response;Risk;sex;skills;Smoke;Smoking;spatiotemporal;Statistical Methods;Toxic effect;Training;Treatment Cost;Uncertainty;United States;Wildfire

PROJECT_TITLE: Improved estimation of wildfire smoke exposures: Characterizing kidney disease risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 ARL-D (C9)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Human Cytomegalovirus (HCMV) is a widespread pathogen that causes congenital birth defects and serious morbidity in immunosuppressed individuals, yet unique aspects of its protracted replication cycle remain poorly understood. In the prior award, we used innovative live cell imaging and artificial intelligence-based approaches which revealed that HCMV forms an unusual microtubule organizing center that rotates the host nucleus to control intranuclear polarity. In this renewal application, new preliminary data supports a central hypothesis that microtubule-driven nuclear rotation is part of a broader, previously unrecognized cytoskeletal mechano-transduction pathway that is coopted by HCMV to control specific gene expression programs that drive cell migration and virus spread.

PI_NAMEs: WALSH, DEREK  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acetylation;Acquired Immunodeficiency Syndrome;Actins;Adhesives;Adult;Appearance;Architecture;Artificial Intelligence;automated image analysis;Award;Back;Behavior;calponin;Cell Differentiation process;cell motility;Cell Nucleus;cell preparation;Cell-Matrix Junction;Cells;Centrosome;Chromatin;Color;Communication;Complex;Confined Spaces;Congenital Abnormality;convolutional neural network;Coronary;Cytomegalovirus;Cytomegalovirus Infections;Cytoplasm;Cytoplasmic Structures;Cytoskeleton;Data;deep learning;Development;DNA biosynthesis;DNA Viruses;Dominant-Negative Mutation;Down-Regulation;Dynein ATPase;emerin;Ensure;Environment;Event;Filament;fluidity;Focal Adhesions;Gene Expression;Genes;Genetic;genetic regulatory protein;Genomic approach;Genomic DNA;Golgi Apparatus;Health;Herpesviridae;Heterochromatin;Human;Human Characteristics;Hyperactivity;Image;imaging approach;immunosuppressed;Individual;Infection;innovation;insight;Lamin Type A;Lamin Type B;live cell imaging;Mechanics;mechanotransduction;Mediating;Microfilaments;Microtubule-Organizing Center;Microtubules;migration;Modeling;Morbidity - disease rate;Motility;Nature;neural network;novel;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;particle;pathogen;Pathway interactions;Patients;Play;Positioning Attribute;prevent;programs;Proteins;Regulation;RNA Interference;Role;Rotation;Secretory Vesicles;segregation;Series;Side;Site;Source;Structure;Surface;Symptoms;Testing;Time;tool;transcriptome sequencing;Transplant Recipients;Vaccines;Vesicle;Viral;viral DNA;viral genomics;Virion;Virus

PROJECT_TITLE: Nuclear rotation and cellular reorganization during Cytomegalovirus infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Sleep Research

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The current proposal focuses on the escalation of anxiety severity across adolescence and aims to elucidate a developmental mechanism rooted in the functional balance between the amygdala and hippocampus. We propose a developmental model for how altered amygdalo-hippocampal function in early adolescence contributes to heightened emotional reactivity, disturbed sleep neurophysiology, and the overgeneralization of negative memories, which in turn leads to the rise of internalizing symptom severity in mid-late adolescence. Support for our model would suggest that the functional balance between key brain structures in sensitive developmental periods are central to the course and severity of anxiety and related disorders and may point to novel biomarkers and interventions.

PI_NAMEs: MATTFELD, AARON  (contact);MCMAKIN, DANA L

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Age;Amygdaloid structure;Anxiety;Anxiety Disorders;anxiety symptoms;anxious;Arousal;Behavior;behavior measurement;Biological;Brain;Childhood;Clinical;Clinical assessments;Cognition;cognitive function;cohort;Communication;Data;Data Set;density;Development;Dimensions;Disease;Distress;early adolescence;Emotional;emotional behavior;emotional distress;Emotions;Enrollment;Equilibrium;Feeling suicidal;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Health;high risk;Hippocampus;Hispanic;Homeostasis;Homosynaptic Depression;Human;Hyperactivity;Individual;Individual Differences;innovation;Intervention;Latinx;Literature;longitudinal course;longitudinal dataset;Maps;Memory;Memory impairment;Mental Depression;Mental disorders;Mental Health;Methods;Modeling;National Institute of Mental Health;neurobehavioral;neuroimaging;neurophysiology;novel;novel marker;Participant;Pattern;Personal Satisfaction;Polysomnography;poor sleep;recruit;Research;response;Retrieval;Risk;Role;Sampling;Severities;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;Sleep Stages;Slow-Wave Sleep;social;Social Change;Stimulus;Strategic Planning;Structure;suicidal behavior;Symptoms;Testing;theories;Time;Youth

PROJECT_TITLE: Sleep-dependent Negative Overgeneralization in Adolescent Anxiety

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Activation of DNA-sensing pathways causes autoinflammation and disease in humans and in mice. Our laboratory generated the first model of autoinflammation mediated by STING, a key regulator of DNA sensing in the cytosol, and this allowed us to discover new functions of STING in nontranscriptional regulation of cytokine secretion, as well as a new role for STING in macrophages and innate lymphoid cells. In this project, we will use new animal models to further define mechanisms of STING-associated autoinflammation and cytokine secretion.

PI_NAMEs: MINER, JONATHAN J (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adoptive Transfer;Animal Model;Animals;autoinflammation;autoinflammatory diseases;Award;Biological Models;Bone Marrow Transplantation;Cell Physiology;cell type;Cells;chemokine;Chronic;Cre-LoxP;CRISPR screen;cytokine;cytopenia;Cytosol;Data;defined contribution;Development;Disease;DNA;Endosomes;Endothelial Cells;Endothelium;Epithelial Cells;functional restoration;gain of function;gain of function mutation;Genes;Goals;Golgi Apparatus;Helper-Inducer T-Lymphocyte;Hematopoietic;Human;IFNGR1 gene;Immune;Immunologics;infancy;Inflammatory;Interferon Type I;Interferon Type II;Interferons;Interstitial Lung Diseases;Knock-in Mouse;Knock-out;Laboratories;Leukocytes;LoxP-flanked allele;Lung Diseases;Lymphocyte;Lymphocyte Function;Lymphoid Cell;Lymphoid Tissue;Macrophage;Macrophage Activation;Mediating;Modeling;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Myeloid Cells;novel;Pathogenesis;Pathology;Pathway interactions;Phenotype;Physiological;Production;Proteins;Publishing;radioresistant;Rag1 Mouse;recruit;Regulation;Role;Signal Transduction;skin lesion;Stimulator of Interferon Genes;Stimulus;STING-associated vasculopathy;Structure;T-Lymphocyte;tertiary lymphoid organ;trafficking;Transgenic Organisms;type II interferon receptor;Up-Regulation;Vascular Diseases;whole genome;Work

PROJECT_TITLE: Mechanisms of STING-associated autoinflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-M (90)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The rate of preterm birth has remained stable at 10% in the United States and it is the predominant cause of both perinatal mortality and long-term pediatric morbidity. Preterm birth is largely driven by the great obstetrical syndromes (preterm birth and ischemic placental disease), which appear to be responsive to low dose aspirin. This randomized trial is designed to test the efficiacy of dose-escalation of aspirin on recurrent preterm birth and ischemic placental disease, and evaluating the underlying mechanisms by which aspirin may impact recurrent preterm birth.

PI_NAMEs: ANANTH, CANDE V.;CLIFTON, REBECCA GERSNOVIEZ (contact);HOFFMAN, MATTHEW KENDALL;REDDY, UMA

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Abruptio Placentae;Address;Adrenal Cortex Hormones;Affect;Animal Model;antenatal;Aspirin;Basic Science;Biochemical Markers;Biological Assay;Birth;Cardiovascular system;Cervical;Childhood;Chronic;Clinical;Clinical Research;Complex;cyclooxygenase 1;Data;data management;design;Diagnosis;Discipline of obstetrics;Disease;Dose;Double-Blind Method;Enrollment;epidemiology study;experience;Failure;Fetal Growth Retardation;Goals;High Risk Woman;Hypertension;Iatrogenesis;improved;improved outcome;Inflammation;Inflammation Mediators;inflammatory marker;innovation;insight;Intervention;Invaded;Ischemia;Knowledge;Laboratories;Leadership;Learning;Length;Literature;low and middle-income countries;Measures;Mediator;Medical;Meta-Analysis;Morbidity - disease rate;mortality;neonatal care;neonatal period;Nulliparity;obstetric outcomes;obstetrical complication;obstetrical syndromes;Oral;Outcome;Pathway interactions;Perinatal;Perinatal mortality demographics;pill;Placebos;Placenta;Placenta Diseases;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnant Women;Premature Birth;prevent;Prevention;Prevention strategy;Prevention therapy;Production;Progesterone;PTGS2 gene;public health intervention;Publications;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recurrence;recurrence prevention;Reporting;Research;Resistance;response;Risk;screening;socioeconomics;Statistical Data Interpretation;Supplementation;Testing;Thrombosis;Thromboxane B2;Tocolytic Agents;United States;Woman

PROJECT_TITLE: A Dose Escalation Study of Low Dose Aspirin for the Prevention of Recurrent Preterm Birth

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This competing continuation of the National Neuropsychology Network (NNN, R01MH118514) will continue to acquire detailed data about neurocognitive function, integrate data from electronic medical records, and make all the data available for shared analysis via the NIMH Data Archive. The continuation phase aims to include more than 10,000 new participants, adding to more than 10,000 participants enrolled in the initial project period, with special emphases on recruiting individuals who report Black or African American race and Hispanic or Latino ethnicity, including those who are bilingual or monolingual Spanish speakers. Analyses will help address inequities in access to and interpretation of neuropsychological tests that have previously had adverse impacts on underrepresented racial and ethnic groups, and increase overall understanding and efficiency of neuropsychological testing for both research and clinical enterprises.

PI_NAMEs: BILDER, ROBERT M (contact);DRANE, DANIEL L;LORING, DAVID W.;STRUTT, ADRIANA MACIAS;UMFLEET, LAURA GLASS

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: access disparities;Acculturation;Address;African American;application programming interface;aspirate;bilingualism;Biomedical Research;Black American;Brain;California;Clinic;Clinical;clinical application;clinical research site;clinical translation;clinically relevant;college;Common Data Element;computerized;Computerized Medical Record;COVID-19 pandemic effects;Data;data acquisition;Data Analyses;data archive;data integration;Databases;demographics;Deposition;Development;Diagnostic;digital;Disparity;Educational process of instructing;Electronic Health Record;Elements;Enrollment;Equity;Ethnic Origin;Ethnic Population;Florida;Funding;Goals;Healthcare;Hispanic;Hispanic Populations;Individual;Inequity;Informatics;Information Retrieval;Infrastructure;innovation;innovative technologies;instrument;Language;Latino;Leadership;Linguistics;Link;Manuals;Measurement;Measures;Medical History;medical schools;Medicine;Methods;Modeling;Modernization;National Institute of Mental Health;Network Infrastructure;Neurocognitive;Neuropsychological Tests;Neuropsychology;novel;Outcome;Paper;Participant;participant enrollment;Patient Recruitments;Patient Self-Report;Performance;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Policies;Population;Population Heterogeneity;Population trends;Procedures;Protocols documentation;Psychometrics;Race;racial population;Recording of previous events;recruit;Reporting;Research;Research Personnel;response;Retrieval;Sampling;Services;Site;social health determinants;social structure;software development;software systems;Source;Spanish;Spanish/English;Specific qualifier value;Standardization;statistics;Structure;System;Testing;Texas;theories;Translational Research;United States National Institutes of Health;Universities;web app;web platform;Wisconsin;Work

PROJECT_TITLE: National Neuropsychological Network (NNN)

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Social Determinants of Health

PHR: Project Narrative Congregate settings and communities of color have been shown to have higher rates of methicillin-resistant Staphylococcus aureus. Understanding the role places like jails play in community transmission of MRSA, could provide insights into community transmission, and provide the possibility of improving surveillance within the community and interventions within the jail. Using a modeling approach that considers closely related genomes, this proposal aims to determine the factors (i.e., individual, and community-level factors) that are associated with jail MRSA transmission and whether jail amplifies the transmission of MRSA within the community.

PI_NAMEs: ADEDIRAN, TIMILEYIN  (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: Address;Amplifiers;Back;Black Populations;burden of illness;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chicago;Clinical;Color;Communities;community transmission;community-level factor;cooking;County;Data;design;Epidemic;Epidemiologic Methods;Epidemiologist;Epidemiology;Event;feeding;Genome;genome sequencing;Genomics;Health Care Rationing;Health system;Healthcare;High Prevalence;high risk population;Imprisonment;improved;Individual;Infection;insight;Intervention;Jail;Knowledge;Length of Stay;Longitudinal cohort;low socioeconomic status;mathematical model;Metadata;methicillin resistant Staphylococcus aureus;Modeling;Morbidity - disease rate;mortality;pathogen;Pattern;people of color;Play;Population;Prevalence;prevent;Prisoner;Prisons;rearrest;recidivism;Research;Resources;Risk;Role;Shelter facility;skills;Social Network;Staphylococcus aureus infection;Testing;Training;transmission process;underserved community;whole genome

PROJECT_TITLE: Elucidating the role of jails in MRSA community transmission

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-E(20)L]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dietary Supplements;Digestive Diseases;Foodborne Illness;Infectious Diseases;Nutrition;Pediatric;Prevention

PHR: PROJECT NARRATIVE To improve the long-term consequences of diarrhea, including malnutrition, recurrent diarrhea, and enteric dysfunction, it is critical to identify new, non-antibiotic interventions to reduce underlying intestinal damage and enteric pathogen carriage. This placebo-controlled, four-armed randomized control trial aims to determine the efficacy and mechanisms of action of two safe and inexpensive milk-derived nutritional supplements, lactoferrin and lysozyme, administered for 16-weeks to Kenyan children recovering from medically attended diarrhea and wasting.

PI_NAMEs: PAVLINAC, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: Acceleration;Acute;Address;Adherence;adverse outcome;aged;Anemia;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Campylobacter;Caregivers;Cessation of life;Child;Childhood;Chinese;Clinical;cognitive development;Cold Chains;Combined Modality Therapy;Convalescence;cost;cost effective intervention;cost effectiveness;Data;Dehydration;Deterioration;Diarrhea;diarrheal disease;dietary supplements;disability-adjusted life years;Double-Blind Method;effective intervention;efficacy evaluation;Enteral;enteric infection;enteric pathogen;enteroaggregative Escherichia coli;Enterobacteriaceae;experience;Failure;Family;Functional disorder;Future;Growth;Health;Health care facility;Health system;Hemoglobin;high risk;Home;Hospitalization;Hydration status;improved;improved outcome;Incidence;Infection;Inpatients;Intervention;Intestines;Iron;Kenya;Lactoferrin;Lactulose;Length of Stay;low and middle-income countries;Lower Respiratory Tract Infection;Malaria;Malnutrition;Medical;medical attention;micronutrient deficiency;Micronutrients;Milk;mortality risk;Muramidase;Neopterin;novel;Nutritional;ORALIT;Outcome;Outpatients;Participant;Peroxidases;Peru;Peruvian;Placebo Control;Placebos;Population;Prevalence;prevent;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;Recovery;Recurrence;Reporting;Rhamnose;Risk;Risk Reduction;Safety;Shigella;standard of care;Supplementation;Testing;Therapeutic Intervention;Time;Translating;Trypsin;Upper arm;Visit;wasting;Zinc

PROJECT_TITLE: Lactoferrin and lysozyme to promote nutritional, clinical, and enteric recovery: A factorial placebo-controlled randomized trial among children with diarrhea and malnutrition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative: Bipolar disorder (BD) is a complex, heritable disease with poorly understood etiology. We found an ANK3 loss of function variant, expressed in oligodendrocytes, that is strongly protective against BD. We will determine the function and role of oligodendroglial isoforms of ANK3 and their contributions to the oligodendrocyte function and the pathogenesis of BD.

PI_NAMEs: RASBAND, MATTHEW N (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adolescence;Adult;Affect;Age Months;Amino Acids;ANK3 gene;autism spectrum disorder;Axon;Behavior;Bioinformatics;Biological;Bipolar Disorder;Brain;Cell Adhesion Molecules;Code;Complex;conditional knockout;Defect;Development;Diagnosis;Disease;Etiology;Exons;Functional disorder;gain of function;Gene Expression;Genes;Genetic;genome wide association study;Genotype;Heritability;hypomania;insight;Intercellular Junctions;Knockout Mice;Link;Lipids;Location;loss of function;Modeling;Modification;Molecular;Moods;mouse model;Mus;Myelin;myelination;Neural Conduction;neurofascin;Neurons;neuropsychiatric disorder;novel;old mice;Oligodendroglia;overexpression;Pathogenesis;Persons;Physiology;Play;Potassium Channel;Protein Isoforms;Ranvier's Nodes;Reporting;Reproducibility;Risk;RNA Splicing;Role;Scaffolding Protein;Schizophrenia;Signal Transduction;Site;Structure;Symptoms;Transcript;Treatment Efficacy;United States;Variant;white matter

PROJECT_TITLE: Oligodendroglial isoforms of ANK3 and their role in CNS function

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Fifteen percent of children are affected by genetic neurodevelopmental disorders that impair their cognitive and communication abilities. The proposed studies will investigate a human genetic disease of intellectual disability and lack of speech. Our findings will elucidate specific molecular pathways that are important for normal brain development and communication, and will lay the groundwork for future treatment strategies in disorders with communication deficits.

PI_NAMEs: CHAHROUR, MARIA  (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Abbreviations;Address;Adult;Affect;Applied Genetics;autism spectrum disorder;benzothiophene;Biochemical;Body Weights and Measures;Brain;Carboxylic Acids;Child;Clinical;Co-Immunoprecipitations;Cognition;Cognitive;Communication;communication behavior;Complex;conditional knockout;conditioned fear;Data;Data Set;Development;Disease;effective therapy;Enzymes;Equilibrium;experimental study;Future;gene function;Genes;Genetic;genetic architecture;Genetic Diseases;Genomics;Goals;Growth;Health;Hearing;Human;Human Genetics;Immunoprecipitation;Impairment;in vivo;inhibitor;insight;Intellectual functioning disability;Keto Acids;Knock-out;Knockout Mice;Knowledge;Laboratories;Language;Learning;loss of function;Measures;Mediating;Memory;Metabolic Pathway;Molecular;morris water maze;Motor;mouse model;muscle strength;Mutation;nerve stem cell;neurobehavioral;Neurodevelopmental Disorder;Neurons;novel;novel therapeutic intervention;Oxidoreductase;Pathogenicity;Pathway interactions;Patients;Phenotype;Phosphorylation;Phosphotransferases;Physiological;postnatal;Process;protein protein interaction;Proteins;Proteomics;Research;Role;Social Behavior;social communication;Speech;Syndrome;targeted treatment;Testing;treatment strategy;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;Ultrasonics;Validation;vocalization;Western Blotting;Work

PROJECT_TITLE: Molecular mechanisms underlying vocal communication

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: New York

ORG_NAME: HOSPITAL FOR SPECIAL SURGERY

PHR: Genes responsible for inflammation are tightly controlled by an enzyme RNA Polymerase II, that binds the beginning of each gene, pauses, and then transcribes genes to complete RNAs that ultimately give rise to proteins. Our recent studies show that in immune cells called macrophages, Polymerase `pause-release' is a critical step that determines how well most inflammatory genes are transcribed. Our proposal aims to understand the mechanisms of `pause-release' and the utility of chemicals that target pausing as future anti-inflammatory drugs for autoimmune diseases such as rheumatoid arthritis.

PI_NAMEs: ROGATSKY, INEZ  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Acute;anti-cancer research;Anti-Inflammatory Agents;arthropathies;attenuation;Autoimmune Diseases;Behavior;Binding;bone;bone invasion;cancer therapy;Cartilage;Cells;Chemicals;Chromatin;Chronic;Complex;cyclin T1;Data;Dependence;Disease;Elongation Factor;Endotoxins;Enhancers;Enzymes;Epigenetic Process;Equilibrium;Future;Gene Expression;gene induction;Genes;Genetic;Genetic Transcription;genome-wide;Glucocorticoid Receptor;Glucocorticoids;Goals;Health;Hyperactivity;Immune;Immunity;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Arthritis;Inflammatory Response;inhibitor;insight;Invaded;Ligand Binding;Macrophage;Malignant - descriptor;Malignant Neoplasms;Mediating;Modeling;Molecular;mouse model;Mus;negative elongation factor;neoplastic cell;NF-kappa B;novel;novel therapeutic intervention;Pathogenesis;Pathology;Pathway interactions;Patient Care;Peritonitis;permissiveness;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Play;Polymerase;Positive Transcriptional Elongation Factor B;Pre-Clinical Model;Productivity;Progressive Disease;Proliferating;promoter;Proteins;Publishing;recruit;Regulation;Reporting;Repression;response;Rheumatoid Arthritis;RNA;RNA Polymerase II;Role;Shock;Signal Transduction;small molecule;Testing;Therapeutic;Therapeutic Glucocorticoid;Time;Tissues;Toxic effect;Transcription Elongation;transcription factor;Transcription Factor AP-1;Transcription Initiation;Transcriptional Regulation;transcriptome;Translating;tumor;Work

PROJECT_TITLE: Post-Initiation control of transcription in inflammatory macrophages

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed research is relevant to public health because lysine deacetylases are targets of drugs approved for treatment of several human pathologies and are under investigation for use against additional diseases. A more thorough understanding of basic lysine deacetylase functions in regulation of transcription will promote efficient clinical use of these approved therapeutics and the development of more targeted inhibitors for regulating the epigenome in disease treatment.

PI_NAMEs: SMITH, CATHARINE LYNN (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Biochemical;Biological Assay;Biological Models;cancer therapy;Cell Physiology;Cells;ChIP-seq;Chromatin;Circadian Rhythms;Clinical;Collaborations;Complex;Coupled;course development;Data;Deacetylase;Development;Disease;Doctor of Philosophy;Drug Targeting;Enhancers;Ensure;Epigenetic Process;epigenome;experience;Fluorescent in Situ Hybridization;Formulation;Frequencies;gene repression;Genes;genetic corepressor;Genetic Transcription;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Goals;Histone Deacetylase;Histone H3;Human Pathology;immune function;Immunoprecipitation;Impairment;inhibitor;innovation;Investigation;Kinetics;Knowledge;Life;Ligands;live cell imaging;Lysine;Maintenance;Measures;Mediating;Metabolism;Methods;Modeling;Molecular;Nervous System Disorder;next generation sequencing;novel;NuRD complex;Patients;Pharmaceutical Preparations;Physiological Processes;prevent;promoter;Proteins;Public Health;Publishing;recruit;Regulator Genes;Regulatory Element;Research;Resources;RNA Polymerase II;Role;Signal Induction;Signal Transduction;single molecule;Site;Small Interfering RNA;Steroid Receptors;Steroids;Study models;Testing;Therapeutic;Therapeutic Uses;Toxic effect;Transactivation;Transcript;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcriptional Activation;Transcriptional Regulation;United States National Institutes of Health;Work

PROJECT_TITLE: The Positive Roles of Lysine Deacetylase Complexes in Regulating Transcriptional Dynamics

STUDY_SECTION: MGB

STUDY_SECTION_NAME: Molecular Genetics B Study Section[MGB]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Precise control of neural stem cell proliferation and differentiation is critical for human brain development and function. Using innovative approaches integrating stem cell technology, genome editing, proteomics and super- resolution microscopy in a human relevant model system, we will investigate the role of an autism susceptibility gene, TAOK2 kinase, in neural stem cell proliferation and differentiation, as well as elucidate how its dysfunction contributes to signaling deficits in neural progenitor cells derived from patients with clinically diagnosed autism spectrum disorder. Findings from these studies will increase our understanding of the complex mechanisms that guide and regulate early human neurogenesis, and will inform on potential future targets for the development of novel therapeutic interventions for neurodevelopmental diseases.

PI_NAMEs: YADAV, SMITA  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 16p11.2;3-Dimensional;Affect;autism spectrum disorder;base;Biochemical;Biological Assay;Biological Models;Biology;Brain;Cell Differentiation process;Cell Line;Centrioles;Centrosome;chemical genetics;Cilia;cilium biogenesis;Clinical;clinical diagnosis;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Data;Defect;Development;Disease;Dissection;domain mapping;endophenotype;Event;experimental study;Fluorescence;FRAP1 gene;Functional disorder;Future;gain of function mutation;Genes;Genetic;genetic risk factor;genome editing;genomic locus;Growth;Human;Human Development;human disease;Human Engineering;human induced pluripotent stem cells;Image;induced pluripotent stem cell technology;innovation;insight;Knock-out;Length;loss of function;Maps;Mass Spectrum Analysis;Mediating;Mental disorders;Methodology;Microscopy;Molecular;Mothers;Mutation;nerve stem cell;Nervous System Disorder;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuron development;Neurons;neuropathology;neuroregulation;Neurosphere;novel therapeutic intervention;null mutation;Organoids;Outcome;Pathogenesis;Pathology;Pathway interactions;patient variability;Patients;Phosphorylation;Phosphotransferases;Protein-Serine-Threonine Kinases;Proteins;Proteome;Proteomics;Research Proposals;Role;Sampling;sensor;Signal Pathway;Signal Transduction;Stem Cell Development;stem cell model;stem cell proliferation;stem cell technology;Structural defect;Structure;superresolution imaging;superresolution microscopy;Susceptibility Gene;Synapses;Techniques;Testing;ultra high resolution;Work

PROJECT_TITLE: TAOK2 Kinase Signaling in Human Neural Stem Cell Development


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Women's Health Research

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative - Relevance  Using the Pavlovian fear conditioning paradigm, the proposed experiments outlined in this document will expand the current literature on the physiological underpinnings of fear memory storage. Enhanced understanding of the biological mechanisms underlying fear memory storage are important not only for increasing our basic knowledge of this process but also for the potential translation of research findings to both normal and disordered memory in humans.

PI_NAMEs: JAROME, TIMOTHY JOSEPH (contact)

PROJECT_TERMS: Affect;Amygdaloid structure;Behavioral Model;Binding;Biological;Biological Assay;Brain;Brain region;Cell Nucleus;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;conditioned fear;design;Development;Disease;DNA;DNA Methylation;DNMT3a;Emotional;Etiology;experimental study;fear memory;Female;Fright;Gene Expression;Genes;Genetic Transcription;Goals;Human;Impairment;in vivo;Knowledge;Learning;Literature;male;Mass Spectrum Analysis;Mediating;Memory;Memory Disorders;memory retention;Mental disorders;Methyl-CpG-Binding Protein 2;Methylation;Modeling;Molecular;multicatalytic endopeptidase complex;next generation;novel therapeutic intervention;Nuclear;Nuclear Protein;Pharmacology;Physiological;Polyubiquitination;Population;Post-Traumatic Stress Disorders;Predisposition;Process;Promoter Regions;Protein Biosynthesis;protein degradation;Proteins;Rattus;Regulation;response;Rodent;Role;sex;Sex Differences;Shock;Symptoms;System;Technology;Testing;therapeutic development;Training;Transcriptional Regulation;transcriptome sequencing;translational potential;Translational Research;Ubiquitin;ubiquitin mediated proteasome degradation;Ubiquitination;whole genome;Work

PROJECT_TITLE: The role of sex- and cell-type specific protein degradation increases in the amygdala in fear memory formation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE In line with NIMHD’s call for initiatives to resolve minority mental health disparities in Latina-American women, this proposal examines the explanatory role of family-endorsed gender scripts on mental affect such as depression, anxiety, and stress susceptibility. Utilizing social-psychological basic psychological needs perspectives, this proposed study examines cultural female gender script, marianismo, that has notably mixed protective or risk effects across behavioral and relational levels of analysis. To resolve this debate, this proposal is the first to identify discrepancies between familial expectations of women’s behavior and actual personal endorsement of traditional marianismo gender scripts as mapped onto relatedness and autonomy psychological needs within the self-determination theory framework. Further, this model examines the statistical validity of three separate operationalizations of marianismo self and familial-endorsed discrepancies that might buffer (or exacerbate) depression, anxiety, and stress symptoms in Latina-American women to better diagnose and tailor clinical interventions.

PI_NAMEs: MARTINEZ, ANJELICA MERCEDES (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Accounting;Address;Adult;Adult Children;Affect;African American population;American;Anxiety;anxiety symptoms;Attitude;Behavior;Behavioral;Belief;Belief System;Buffers;Caring;Clinical;cohesion;Conflict (Psychology);coping;Data;depressive symptoms;Diagnosis;Disparate;Disparity;Emotional;ethnic minority population;expectation;experience;Family;Family member;Feeling;Female;Frustration;Funding Opportunities;Future;Gender;Goals;grandparent;health disparity;Individual;Influentials;interest;Intervention;Latina;Latina Population;Latino;Latinx;Latinx population;life span;Link;Maps;Mediating;Mediation;member;men;Mental Depression;Mental disorders;Mental Health;Mental Health Associations;Methods;Minority;Minority Groups;Modeling;Morals;Motivation;National Institute on Minority Health and Health Disparities;negative affect;Outcome;Parents;Personal Autonomy;Population Growth;Predisposition;Prevalence;Process;protective factors;Psyche structure;psychologic;Psychological Theory;Publications;racial minority population;Research;Risk;Risk Factors;Role;satisfaction;Self Determination;Siblings;social;Source;Specific qualifier value;Spirituality;Stress;stress symptom;success;Testing;theories;Woman;Work

PROJECT_TITLE: Examining Perceived Familial and Self-Endorsement of Marianismo Cultural Script Discrepancies as Mental Health Risk Factors in Latina Americans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Relevance T lymphocytes comprise an essential component of the immune response to infections caused by all categories of infectious agents. Currently, the power of T cell immunity is being harnessed for the treatment of cancers as well as chronic viral infections. Our studies aim to provide detailed information about the pathways that regulate distinct T cell responses. This information will be used to manipulate T cells to provide the most effective therapeutic potential.

PI_NAMEs: BERG, LESLIE JOAN;HUSEBY, ERIC S (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Acute;Anatomy;Antigens;Autoantigens;Autoimmune Diseases;Automobile Driving;Binding;Biophysics;cancer therapy;Categories;Cell Physiology;Cells;Chronic;Clone Cells;Data;deep sequencing;density;design;Development;Disease;Effector Cell;Family;FOXP3 gene;Genetic Models;Health;Homeostasis;Immune;Immune response;Immunity;Immunosuppression;Individual;Infection;Infectious Agent;Inflammation;Inflammatory;insight;Kinetics;Ligand Binding;Ligands;Locales;Location;Lymphocyte Function;Mass Spectrum Analysis;migration;Modeling;Molecular;Mus;Neonatal;novel;nuclear factors of activated T-cells;Organ;Pathway interactions;Pattern;Peptide Initiation Factors;Peptide/MHC Complex;Peptides;Perception;Peripheral;Phosphotransferases;Property;Regulatory T-Lymphocyte;response;Rest;Role;Sanguisorba;Signal Pathway;Signal Transduction;Site;Specific qualifier value;Specificity;Stimulus;synergism;T cell response;T-Lymphocyte;Testing;theories;Therapeutic;therapeutically effective;thymocyte;Thymus Gland;Time;Tissues;Virus Diseases;Weber Fechner Law

PROJECT_TITLE: TCR signaling control of thymic Treg selection and immune homeostasis

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Obesity;Substance Misuse

ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative Alcohol use is highly prevalent among individuals with binge eating and may contribute to the maintenance of binge eating, however the effect of alcohol consumption on future binge eating episodes has not yet been studied. The proposed project will use laboratory alcohol administration and test meals to study the effect of consuming a moderate amount of alcohol on binge eating among individuals with clinically significant binge eating. Findings from the proposed project may inform treatment recommendations for individuals with binge eating by clarifying whether and for whom moderate alcohol consumption results in a binge eating episode.

PI_NAMEs: WILKINSON, MEGAN  (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Acute;Adult;Alcohol consumption;alcohol effect;alcohol research;Alcohols;anxiety symptoms;Behavior;Beverages;Binge Eating;Binge eating disorder;Biological Markers;Blood alcohol level measurement;Bulimia;Calories;career;Clinical;clinically significant;Confounding Factors (Epidemiology);Consumption;Data;Data Analyses;Data Collection;depressive symptoms;Development;Diagnostic;Disinhibition;Dose;drinking;Eating;Eating Behavior;Eating Disorders;eating pathology;Emotions;Evidence based treatment;experience;Experimental Designs;experimental study;food consumption;Frequencies;Future;Goals;heart rate variability;High Prevalence;high risk;Hyperphagia;increased appetite;Individual;Individual Differences;individualized medicine;Informal Social Control;Intervention;Interview;Knowledge;Laboratories;Literature;loss of control over eating;Maintenance;Measures;Medical;Mental Depression;non-alcoholic;Obesity;Overweight;Participant;Pattern;Physiological;Placebos;psychiatric comorbidity;Recommendation;Reporting;Research;Research Design;Research Support;Risk;Risk Reduction;Role;Sampling;Standardization;Subgroup;Symptoms;Testing;Training;Woman

PROJECT_TITLE: An experimental study of the effects of alcohol intake on subsequent binge eating among adults with clinically-significant binge eating.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Each time DNA is replicated during the process of cell proliferation, histone proteins are synthesized in large amounts to package newly made DNA into chromosomes. We will combine biochemical and genetic studies in the fruit fly Drosophila to study the mechanisms and regulation of the synthesis of histones proteins. Factors controlling histone synthesis are critical for stable inheritance of genetic information during organism development, and thus for the suppression of human disease. Because of high evolutionary conservation, our studies in flies will allow us to understand the function of these factors in humans.

PI_NAMEs: DURONIO, ROBERT J;MARZLUFF, WILLIAM F. (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Affect;Anabolism;Animals;Architecture;Area;Binding;Biochemical;Biological Assay;Cell Culture Techniques;Cell Cycle;Cell Cycle Regulation;Cell Nucleus;Cell Physiology;Cell Proliferation;cell type;Cells;Chromatin Modeling;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Cryoelectron Microscopy;Development;DNA;DNA biosynthesis;Drosophila genus;Elements;Embryo;endonuclease;Engineering;fly;Gene Cluster;Gene Expression;Gene Expression Regulation;gene replacement;Gene Structure;Generations;Genes;genetic approach;genetic information;Genetic study;Genetic Transcription;Genome;Genomic Instability;Genotype;Goals;Grant;Histones;Human;human disease;imaging approach;in vivo;Malignant Neoplasms;Mammals;Mediating;Messenger RNA;Methods;Molecular;mRNA Precursor;Mutagenesis;mutant;novel;Nuclear;Oogenesis;Organism;Pattern;Play;Poly A;polyadenylated messenger RNA;Polyadenylation;Process;Production;promoter;Protein Biosynthesis;Proteins;Regulation;replication stress;Resolution;RNA biosynthesis;RNA Processing;Role;S phase;Signal Transduction;stem;Structure;superresolution microscopy;Supporting Cell;System;Tail;Time;transcription termination;Transcriptional Activation;Transcriptional Regulation;U7 Small Nuclear Ribonucleoprotein;ultra high resolution;Variant;Zinc Fingers

PROJECT_TITLE: Histone mRNA Regulation in Development


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: CHAMPAIGN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: RNA polymerase III transcribed genes play critical roles in translation, splicing, and transcription regulation, yet these genes are commonly overlooked due to unique challenges related to the sequencing and alignment of short, repetitive RNAs. Thus, the level and function of dynamic RNA polymerase III transcription during cellular differentiation remains poorly understood. The proposed project develops new genomic methods for characterizing changes in RNA polymerase III transcription, applies functional experiments to test the role of these changes during cardiac development, and develops a genetic background correction method enabling future comparisons of RNAPIII patterns across diverse tissues and samples of non-identical origin.

PI_NAMEs: VAN BORTLE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: 7SL RNA;Accounting;Address;Bioinformatics;Biological Assay;Biology;Biotin;brain tissue;Breast Cancer Cell;Cardiac;Cardiac Myocytes;cardiogenesis;cardioprotection;Cell Differentiation process;Cell Physiology;cell type;Chemicals;Communities;Computational Biology;Copy Number Polymorphism;Data;Detection;Development;Disease;DNA Polymerase III;Down-Regulation;empowerment;ERBB2 gene;experimental study;Feasibility Studies;follow-up;Funding;Future;gene correction;Gene Dosage;Gene Expression Profile;Gene Structure;Genes;Genetic;Genetic Transcription;genome sequencing;genome-wide;genomic tools;Genomics;Goals;Health;Heart Diseases;Heart failure;Heart Hypertrophy;Human;human disease;human stem cells;Hypoxia;improved;In Vitro;infected B cell;insight;interest;knock-down;Macrophage;Maps;Methodology;Methods;mouse model;Myocardial Ischemia;Nerve Degeneration;novel;Nuclear;overexpression;Oxidative Stress;Parasites;Patients;Pattern;Phase;Pilot Projects;Play;programs;Proliferating;Regulation;Repression;Research;Research Personnel;response;Reverse Transcription;Ribosomal RNA;RNA;RNA Polymerase III;RNA Splicing;RNA-Binding Proteins;Role;Running;Sampling;Sequence Alignment;skills;Small RNA;statistics;stem cells;Structure;success;System;Testing;Tissues;tool;Training;Transcriptional Regulation;transcriptome sequencing;Transfer RNA;Translations;tumor;Untranslated RNA;Variant;Viral;whole genome

PROJECT_TITLE: The development and application of tools to characterize the level and function of RNA polymerase III transcription dynamics during cellular differentiation

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The goal of this research proposal is to identify cellular, metabolic and molecular mechanisms of cerebral cortex abnormalities in cells carrying the 22q11.2 deletion, which is commonly associated with neuropsychiatric diseases. We will study how mitochondrial dysfunction induces metabolic reprogramming and results in abnormal neuronal function. Given that 22q11.2 deletion syndrome is the most commonly diagnosed microdeletion, the proposed project is relevant for public health and has the potential to advance our understanding of brain injury and repair in 22q11.2 deletion syndrome.

PI_NAMEs: PASCA, ANCA MIRABELA (contact)

PROJECT_TERMS: 22q11.2;Action Potentials;aerobic glycolysis;Animal Model;Bezafibrate;Biogenesis;Biological Assay;Blood specimen;Brain imaging;Brain Injuries;brain repair;Calcium;Calcium Signaling;Cell model;cell type;Cells;Cerebral cortex;Defect;Development;Diagnosis;DiGeorge Syndrome;disease model;DNA Sequence Alteration;drug discovery;Electron Microscopy;Electrophysiology (science);Enhancers;Etiology;experimental study;fetal;Functional disorder;Generations;Genes;Genetic Diseases;Genetic Transcription;Genus Hippocampus;Glycolysis;Goals;Human;human induced pluripotent stem cells;Image;imaging study;Impairment;In Vitro;Individual;Induced pluripotent stem cell derived human neuron;insight;Light;Lysine;Metabolic;Metabolic Diseases;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;microdeletion;Microscopy;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Molecular;Morphology;mouse model;Movement;multidisciplinary;Multiplexed Ion Beam Imaging;Mus;nerve stem cell;Neurodevelopmental Disorder;Neurologic Deficit;Neuronal Differentiation;Neuronal Dysfunction;Neurons;neuropsychiatric disorder;nicotinamide-beta-riboside;Oxidative Phosphorylation;Pharmaceutical Preparations;Phenotype;postmitotic;preclinical study;Predisposition;Production;progenitor;Proliferating;Prosencephalon;psychosis risk;Public Health;Research Proposals;Resistance;Resveratrol;Rodent Model;Side;Specificity;spheroids;stem cell differentiation;stem cell proliferation;Stress Tests;Synapses;Syndrome;targeted treatment;Technology;Testing;Therapeutic Intervention;Time;Tissue-Specific Gene Expression;transcriptome sequencing

PROJECT_TITLE: Identification of metabolic alterations during cortical development in a human cellular model for 22q11.2 deletion syndrome


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Schizophrenia and other neuropsychiatric disorders are often associated with abnormal social behavior, with few available treatments. To gain insight into basic neural mechanisms of disease, we study a mouse model of a human genetic deletion syndrome that is strongly linked to schizophrenia. These mice have a deficit in social memory, our ability to recall and recognize other individuals, that is associated with dysfunction in the CA2 region of the hippocampus, a brain area important for different forms of memory. Here we will examine how changes in CA2 brain circuits produce abnormal patterns of neural network activity that impair memory. We will then test whether brain stimulation paradigms that restore network activity can also restore social memory, providing validation for a potential novel therapeutic approach.

PI_NAMEs: SIEGELBAUM, STEVEN A (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: 22q11;22q11.2;Affect;Antisense Oligonucleotides;Area;base;Behavior;Behavioral;Behavioral Mechanisms;Bipolar Disorder;Brain;Code;Deep Brain Stimulation;derepression;detector;Disease;DNA Sequence Alteration;Dominant-Negative Mutation;Down-Regulation;effective therapy;Event;experience;Functional disorder;Funding;Genes;Genetic;Genetic Diseases;Genetic Risk;genetic risk factor;Goals;Golgi Apparatus;hippocampal pyramidal neuron;Hippocampus;Human;human disease;Human Genetics;human model;Impaired cognition;Impairment;in vivo;Individual;Infusion procedures;inhibitor;insight;interest;Light;Link;Membrane Proteins;Memory;memory consolidation;Memory impairment;Messenger RNA;microdeletion;MicroRNAs;Modeling;Molecular;mouse model;Mus;Mutation;neural network;neural patterning;neuromechanism;Neurons;neuropsychiatric disorder;novel;novel strategies;novel therapeutic intervention;novel therapeutics;optogenetics;Pathology;Pattern;pharmacologic;Population Dynamics;Potassium;potassium channel protein TREK-1;protein complex;protein transport;Pyramidal Cells;rational design;Rest;restoration;Role;Schizophrenia;schizophrenia risk;Shapes;Slow-Wave Sleep;small hairpin RNA;social;Social Behavior;social cognition;spatial memory;Synapses;Syndrome;Test Result;Testing;trafficking;Up-Regulation;Validation;Viral;Wild Type Mouse

PROJECT_TITLE: Hippocampal CA2 sharp wave ripple oscillations in neuropsychiatric disease

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) significantly burden youth 13–17 years old in the United States (US). Although all 50 states and the District of Columbia have enacted a number of legal protections with the intention of supporting access to HIV/STI testing, treatment, and prevention services for minors, little-to-nothing is known about the effectiveness of these laws. The goal of the proposed research is to (1) address this knowledge gap; (2) provide actionable evidence for legislators, health organizations, adolescent health care providers, and adolescents themselves; and (3) decrease barriers to HIV/STI testing, treatment, and prevention services for adolescents in the US.

PI_NAMEs: NELSON, KIMBERLY M (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: 17 year old;Address;Adolescent;adolescent health;Affect;Age;AIDS prevention;Amendment;Awareness;Behavior;Behavioral;Centers for Disease Control and Prevention (U.S.);Comprehension;condom use rate;Consent;Data;Data Set;Decision Making;design;Disclosure;District of Columbia;Effectiveness;ethnic minority;ethnic minority status;Evaluation;Exposure to;Family;Fright;Gender;gender minority;gender minority youth;Goals;Growth;Health behavior;health organization;Health Personnel;Health Promotion;Healthcare;HIV;HIV disparities;HIV risk;Human immunodeficiency virus test;Incidence;Intention;Knowledge;Laws;Legal;Link;longitudinal dataset;Methodology;Minor;minority children;Perception;Play;Policies;Population;pre-exposure prophylaxis;Prevention;prevention service;Prevention strategy;Public Health;racial minority;Recommendation;Reporting;Research;Research Personnel;Rights;Risk;Role;screening;Services;sex;Sexual Health;sexual minority;sexual minority status;sexual minority youth;sexually active adolescent;Sexually Transmitted Diseases;Specific qualifier value;Statutes and Laws;Strategic Planning;Surveys;Testing;testing services;Time;transmission process;treatment services;United States;United States National Institutes of Health;uptake;Youth

PROJECT_TITLE: Minor Consent Laws and HIV Prevention Among Adolescents in the United States

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: CAMBRIDGE

ORG_NAME: WHITEHEAD INSTITUTE FOR BIOMEDICAL RES

PHR: 8. PROJECT NARRATIVE Toxoplasma gondii is an important opportunistic pathogen, NIAID category B Biodefense agent, and a model organism for other apicomplexan parasites including Plasmodium spp., the etiologic agents of malaria. The proposed study will characterize a newly discovered protein complex that plays a key role in the ability of parasites to enter the host cells in which they replicate. Characterizing the interactions between host and parasite factors during this initial step of infection will uncover new therapeutic and prophylactic approaches to treat these infectious agents.

PI_NAMEs: LOURIDO, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Animals;Apical;Apicomplexa;Bacterial Adhesins;Binding;Biochemical;biodefense;Biological Assay;Biotin;Carbohydrates;Categories;Cell Membrane Permeability;Cell surface;Cell Surface Proteins;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Conserved Sequence;CRISPR screen;crosslink;Cryptosporidiosis;Cryptosporidium;Dependence;Development;Disease;Distant;Etiology;Event;experimental study;extracellular;Face;Fibroblasts;fitness;Fluorescence-Activated Cell Sorting;Genes;Genetic;genome wide screen;Human;Impairment;Infection;Infectious Agent;Integration Host Factors;Invaded;Ligase;Link;Lipids;Livestock;Lytic Phase;Malaria;Mediating;migration;model organism;Modeling;Molecular;Motility;Names;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;opportunistic pathogen;Organelles;Parasite Control;parasite invasion;Parasites;parasitism;Pathogenesis;Phenotype;Plasmodium;Plasmodium falciparum;Play;preservation;Process;prophylactic;protein complex;Protein Secretion;Protein translocation;Proteins;Regulation;rhoptry;Scheme;Signal Transduction;Structure;Surface;Symptoms;System;Tissues;Toxoplasma gondii;Toxoplasmosis;trafficking

PROJECT_TITLE: Control of parasite invasion by a microneme protein complex conserved in Apicomplexans

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Understanding how inhibitory synapses function in the brain is a major first step in determining how these synapses are disrupted in numerous brain disorders such as stroke and autism. A better understanding of the molecular mechanisms involved in inhibitory synapse regulation will have the potential to direct new therapeutic strategies for management of these conditions.

PI_NAMEs: SMITH, KATHARINE RACHEL (contact)

PROJECT_TERMS: 3-Dimensional;Acute;AMPA Receptors;Animal Behavior;Architecture;autism spectrum disorder;Behavior;Brain;Brain Diseases;Cell Adhesion Molecules;Central Nervous System;Cognition;Computer Models;Data;Disease;disease model;Electrophysiology (science);Epilepsy;Equilibrium;functional outcomes;Future;gephyrin;Glutamates;Goals;Growth;Imaging Techniques;Impairment;information processing;Inhibitory Synapse;Interneurons;Laboratories;Learning;Lighting;Location;Mediating;Memory;Microscopy;Modernization;Molecular;nanoscale;Nervous System Disorder;Neurodevelopmental Disorder;neuroligin 2;neuronal circuitry;neuronal excitability;Neurons;neuropathology;neurotransmitter release;novel;novel therapeutic intervention;Output;palmitoylation;Pathology;Phosphorylation;Play;Positioning Attribute;postsynaptic;postsynaptic density protein;presynaptic;Property;receptor;Regulation;Resolution;Role;scaffold;Schizophrenia;segregation;Site;Slice;Stroke;Structure;superresolution imaging;superresolution microscopy;Synapses;synaptic function;synaptic inhibition;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;three dimensional structure;Time;Work

PROJECT_TITLE: Nanoscale organization of the inhibitory synapse during synaptic plasticity

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Narrative    This  project  will  determine  the  function  of  neural  specific  type  8  adenylyl  cyclase  (Adcy8)  in  regulating  neuronal  signaling,  activity- dependent  reversal/suppression  of  the  previously  acquired traits at cellular and behavioral level. Knowledge gained from this project may provide  new  insights  into  molecular,  synaptic,  and  behavioral  aspects  of  cognitive  and  synaptic  flexibility.  As  defective  cognitive  flexibility  and  neuronal  signaling  are  not  only  associated  with  but  also  predictive  of  daily  function  in  psychological  and  mood  disorders,  outcome  of  this  study  may suggest potential mechanism- based strategies to target impairments in certain domains of  cognitive flexibility.

PI_NAMEs: WANG, HONGBING  (contact)

PROJECT_TERMS: Ablation;Address;Adenylate Cyclase;Adult;Affect;Attenuated;Automobile Driving;Behavioral;Brain;cell type;Cells;Chemosensitization;Cognition;Cognitive;Cognitive deficits;cognitive function;Computer Analysis;conditional knockout;conditioned fear;Cues;Cyclic AMP;daily functioning;Data;Dependence;environmental change;fear memory;flexibility;Frequencies;Gene Expression Profile;Genetic;Glycogen Synthase Kinase 3;glycogen synthase kinase 3 beta;hippocampal pyramidal neuron;Hippocampus;Homosynaptic Depression;Hyperactivity;Impaired cognition;Impairment;insight;Knockout Mice;Knowledge;Label;Learning;Light;Link;Long-Term Depression;Long-Term Potentiation;LoxP-flanked allele;Maps;Mediating;Memory;Mental disorders;Mental Health;Molecular;Molecular Target;Mood Disorders;mouse model;Mouse Strains;Mus;Neuronal Plasticity;Neurons;Neurophysiology - biologic function;neurotransmission;Optics;optogenetics;Outcome;Outcome Study;patient population;patient subsets;Phosphotransferases;Proto-Oncogene Proteins c-akt;restoration;Reversal Learning;Role;Signal Transduction;spatial memory;spatiotemporal;Synapses;synaptic depression;Synaptic plasticity;System;targeted treatment;Therapeutic;therapeutic target;tool;trait;transcriptome;Transgenic Mice;Update;whole genome

PROJECT_TITLE: Mechanism underlying cognitive and synaptic flexibility


NIH_SPENDING_CATS: Cancer

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Among post-translational modifications, protein phosphorylation is the most widely studied because of its involvement in essentially all biological processes and its prevalent role and therapeutic potential in many human diseases. Although protein tyrosine kinases are the targets of several FDA-approved drugs, protein tyrosine phosphatases (PTP) have only recently gained renewed interest as a therapeutic strategy with several compounds entering clinical evaluation. The long-term goal of this research program is development of a proteomics methodology that captures PTP activity on native proteins to advance basic knowledge of molecular specificity for targeting PTP function on a global scale.

PI_NAMEs: HSU, KU-LUNG  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Active Sites;Address;anti-cancer treatment;Antibodies;Azoles;bcr-abl Fusion Proteins;Benchmarking;Binding;Biological Assay;Biological Process;Biology;Cancer Patient;Catalytic Domain;Cell Line;Cell Physiology;Cell Proliferation;cell transformation;Cells;chemical reaction;Chemicals;Chemistry;Clinic;Clinical;Clinical Trials;Communities;Complex;CRISPR/Cas technology;Development;Enzymes;Evaluation;Event;Exhibits;FDA approved;Felis catus;Genetic Models;Goals;Human;human disease;improved;Individual;inhibitor;innovation;insight;interest;Knock-out;Knowledge;Label;Length;Malignant Neoplasms;Maps;Methodology;Methods;Modification;Molecular;Monitor;new therapeutic target;Noise;novel;Oncogenes;Oncogenic;Outcome;Peptides;pervanadate;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenols;phosphatase inhibitor;Phosphopeptides;Phosphoproteins;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;Phosphotyrosine;Physiological;Post-Translational Protein Processing;precision medicine;programs;Proliferating;Protein Dephosphorylation;Protein Tyrosine Kinase;Protein Tyrosine Phosphatase;Proteins;Proteome;Proteomics;PTPN11 gene;Publications;Qualifying;Regulation;Research;research clinical testing;Resources;Role;Sensitivity and Specificity;Signal Transduction;Site;small molecule;Specificity;src Homology Region 2 Domain;Substrate Specificity;Sulfur;System;Technology;Testing;Therapeutic;therapeutic target;Transcriptional Activation;Tyrosine Phosphorylation;Writing

PROJECT_TITLE: Defining and targeting substrate specificity of protein tyrosine phosphatases

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Project Narrative Natural killer (NK) cells are the first line of defense against tumor cells as well as viruses. NK cells and those engineered with a CAR (short for “chimeric antigen receptor”) are promising for cancer treatment; however, challenges still exist, as some tumors are resistant to killing by NK cells, and these cells have a short lifespan after infusion into patients. We discovered that a molecule, XBP1s, enhances NK cell survival and functions, presenting an excellent target to improve NK or CAR NK cell-based immunotherapy.

PI_NAMEs: YU, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: AKT Signaling Pathway;anti-PD-1;anti-PD-L1;Binding;Binding Proteins;Binding Sites;Blood;cancer immunotherapeutics;cancer immunotherapy;cancer therapy;Cell Nucleus;Cell Physiology;Cell Survival;Cell Therapy;Cells;Cellular biology;Cellular Stress;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Cities;Clinic;Combined Modality Therapy;Complex;conditional knockout;cytokine;cytotoxicity;Data;Deubiquitination;Development;Down-Regulation;Educational workshop;Effector Cell;Engineering;Enzymes;Foundations;FOXO1A gene;Gene Expression;Gene Expression Regulation;Genes;Haplotypes;Homeostasis;Human;human data;IFNG gene;Immune response;Immunity;Immunology;Immunotherapy;Impairment;improved;improved outcome;In Vitro;in vivo;Infusion procedures;inhibitor;innovation;Inositol;insight;Interferon Type II;Interleukin-15;interleukin-15 receptor;Journals;KLRD1 gene;life span;Lymphoid Cell;Malignant Neoplasms;Mediating;Messenger RNA;migration;Molecular;Multiple Myeloma;Mus;Natural Killer Cell Immunotherapy;Natural Killer Cell toxicity;Natural Killer Cells;Nature;neoplastic cell;new therapeutic target;novel;novel strategies;Nuclear Protein;Pathway interactions;Patients;Play;Population;Pre-Clinical Model;prevent;Process;Production;Proliferating;promoter;protein expression;Protein Splicing;Proteins;Proto-Oncogene Proteins c-akt;Published Comment;Publishing;receptor;recruit;Recurrent disease;Reporting;Resistance;RNA Splicing;Role;Signal Pathway;Signal Transduction;Signaling Protein;Testing;Time;trafficking;transcription factor;Transforming Growth Factor beta;Translating;tumor;tumor eradication;Tumor-infiltrating immune cells;Virus;Work;XBP1 gene

PROJECT_TITLE: Characterizing and Targeting the Novel IL-15- AKT-XBP1s Pathway in NK Cells

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]