NIH_SPENDING_CATS: Pregnancy;Women's Health Research

PI_NAMEs: RUSYN, IVAN  (contact)

PROJECT_TERMS: Academia;Academy;Address;Adoption;American;Analytical Chemistry;Animal Model;Aspirin;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biomedical Engineering;celecoxib;Cells;Cervix Uteri;Chemicals;Chemistry;commercialization;Complex;Data;data resource;data submission;Database Management Systems;Decidua;Development;Devices;drug candidate;drug development;drug discovery;Drug Industry;Drug Kinetics;drug repurposing;Economics;Encapsulated;Ensure;Evaluation;exosome;experience;Experimental Models;Faculty;FAIR principles;Fees;fetal;Fetal Membranes;Foundations;Funding;Goals;Government;Government Agencies;Health;Healthcare;high standard;Human;Image;In Vitro;Industry;Infrastructure;insight;inter-individual variation;Interleukin-10;International;Laboratories;Letters;Marketing;mathematical model;meetings;Methodology;Methods;microphysiology system;Modeling;National Center for Advancing Translational Sciences;National Toxicology Program;novel;novel marker;novel strategies;Organ;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phase;Physiological;physiologically based pharmacokinetics;Placenta;preclinical safety;Preclinical Testing;Pregnancy;Pregnant Women;Preparation;Privatization;Process;Prokaryotic Cells;prospective;Protocols documentation;public-private partnership;Publishing;Qualifying;quality assurance;Records;Reporting;Reproducibility;research clinical testing;Research Personnel;Resources;response;Risk Assessment;safety assessment;Science;Scientist;Site Visit;small molecule;Source;Standardization;Stream;System;Testing;Texas;Tissue Microarray;Tissues;tool development;Toxic effect;Toxicity Tests;Toxicology;transcriptomics;Translational Research;Trust;United States National Institutes of Health;Universities;Validation;Vision;Women's Health;Work

PROJECT_TITLE: Qualification Core


ADMINISTERING_IC: HS

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: The learning health system is designed to “to generate and apply the best evidence for the collaborative healthcare choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and to ensure innovation, quality, safety, and value in healthcare.” Vanderbilt is committed to establishing the Realizing Accelerated Progress, Investigation, Implementation, and Dissemination in Learning Health Systems (RAPID-LHS) Center to develop a cadre of scientists formally trained and well versed in the best methods for engaging and improving the learning health system. The RAPID-LHS Center will train future scientists and provide support in the following areas of strength: 1) patient-centered outcomes research; 2) dissemination and implementation science; 3) health policy/public health; 4) stakeholder engagement, community health, and health equity; 5) methods advancement.

PI_NAMEs: EMBI, PETER J.;ROTHMAN, RUSSELL L.;ROUMIE, CHRISTIANNE L. (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PI_NAMEs: ROUMIE, CHRISTIANNE L. (contact)

PROJECT_TITLE: Administrative Core


PROJECT_TITLE: Research Education Core


PI_NAMEs: ROTHMAN, RUSSELL L. (contact)

PROJECT_TITLE: Research and Data Analysis Core


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PI_NAMEs: HIMMELFARB, JONATHAN  (contact)

PROJECT_TERMS: Advisory Committees;authority;Bioinformatics;Budgets;Clinical Research;Collaborations;Communication;Communities;Community Outreach;Complex;Data;data dissemination;data sharing;Database Management Systems;drug development;drug efficacy;experience;Fostering;Goals;Human Resources;improved;industry partner;Information Dissemination;Institution;Kidney;Kidney Diseases;Leadership;Manuals;medication safety;meetings;microphysiology system;Monitor;operation;Patients;Performance;Physicians;Procedures;Professional Organizations;programs;protocol development;Protocols documentation;Qualifying;Quality Control;Records;Reporting;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Resources;Running;Science;Scientist;statistics;tool development;Translational Research;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Admin Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 TC-9 (01)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: FREEDMAN, BENJAMIN SOLOMON (contact)

PROJECT_TERMS: Acceleration;Address;Adoption;Aging;Animal Testing;Apical;assay development;Biological Assay;Biological Markers;Biomimetics;Blood Vessels;Businesses;CCL4 gene;Cell Line;Cell model;cell type;Cells;Characteristics;Clinical;clinically relevant;Collaborations;Commercial grade;cost;Cyst;Data Set;Development;Devices;Disease;disease heterogeneity;disease model;disease phenotype;drug development;drug efficacy;Effectiveness;Epithelial Cells;Equipment and supply inventories;expiration;Female;Functional disorder;Gene Expression;Genes;Genetic Diseases;Genetic Models;Goals;Human;human model;improved;in vitro Model;induced pluripotent stem cell;Industry;injury and repair;innovation;Instruction;Kidney;kidney cell;Knowledge;Laboratories;Licensing;Longevity;Maintenance;male;Manuals;manufacture;Marketing;Measures;medication safety;Methods;microphysiology system;Microscopy;Modeling;Modernization;Monitor;mutant;Nephrons;nephrotoxicity;novel therapeutics;Organoids;Patients;Perfusion;pharmacokinetic characteristic;Phenotype;Physiological;Physiology;Procedures;Production;prototype;Proximal Kidney Tubules;Qualifying;Quality Control;Reference Standards;Reporter;Reproducibility;Resources;Safety;Sampling;scale up;self-renewal;Services;Sex Differences;Source;Standardization;Statistical Data Interpretation;success;System;Technology;Testing;therapeutic candidate;therapy development;Time;tool development;Transfer Agreement;Translating;Tubular formation;Validation

PROJECT_TITLE: MPS Resources Section


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

PI_NAMEs: KELLY, EDWARD J (contact)

PROJECT_TERMS: Address;Biological Markers;causal variant;Cells;Characteristics;Cisplatin;Clinical;clinical biomarkers;Clinical Data;clinical effect;Clinical Research;Complex;Cryopreserved Cell;Data Set;Destinations;Development;Devices;Disease;disease phenotype;Distal;DNA Sequence Alteration;Dose;drug development;drug discovery;drug efficacy;Drug Exposure;Drug Kinetics;Drug toxicity;Endothelium;environmental stressor;Enzymes;Epithelial Cells;Exhibits;Expenditure;Failure;Filtration;Furosemide;Genetic;Hereditary Disease;Human;Impairment;improved;insight;Intervention;Kidney;Kidney Diseases;Measures;Mediating;medication safety;Membrane;Microfluidic Microchips;microphysiology system;MicroRNAs;Modeling;Molecular Conformation;nephrogenesis;nephron progenitor;Nephrons;nephropathic cystinosis;nephrotoxicity;Organoids;Pattern;Pharmaceutical Preparations;pharmacokinetic model;pharmacologic;Phase;phase I trial;Phenotype;phenotypic biomarker;Physiological;podocyte;Polycystic Kidney Diseases;Polymyxin B;Population;Pre-Clinical Model;Property;Proximal Kidney Tubules;Qualifying;Renal clearance function;Renal function;Reproducibility;response;Safety;Serum;solute;specific biomarkers;Stimulus;Structure;Technology;Tenofovir;therapeutic candidate;Therapeutic Uses;Tissues;tool;tool development;Toxic effect;transcriptome sequencing;Translations;Treatment Efficacy;Tubular formation

PROJECT_TITLE: MPS Qualifications Section


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Narrative Within VA, among Veterans who have hypertension or diabetes, racial/ethnic minority Veterans are less likely than white Veterans to have these conditions under control. Some of the factors that can lead to poor control of these conditions may be related to the type of health care that the person receives, whereas other factors may be outside of the control of the health care system. Health care sites can sometimes deliver care in a way that will result in more patients achieving good control of their hypertension and diabetes. Our aims are to identify health care sites where there are fewer differences by race/ethnicity and by socio-economic status in the percentage of patients with good control of hypertension and diabetes, and to understand what some of the characteristics of patients, and their health care settings are that are associated with better control of these conditions.

PI_NAMEs: WASHINGTON, DONNA  (contact)

PROJECT_TERMS: Achievement;Address;Administrator;Affect;Alaska Native;American Indians;Attention;Black race;black/white disparity;Caregiver support;Caring;Characteristics;Clinical;clinical practice;cohort;contextual factors;Counseling;Data;Data Display;Data Sources;deviant;diabetes control;Diabetes Mellitus;Diagnosis;Disparity;Disparity population;disparity reduction;Electronics;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;evidence base;Evidence based intervention;Evidence based practice;experience;field study;gender disparity;Goals;Health;health care delivery;health care disparity;health care settings;health equity;Health Services Accessibility;Healthcare;Healthcare Systems;Hispanic;Housing;Hypertension;hypertension control;implementation barriers;implementation research;implementation strategy;improved;improved outcome;Income;Individual;Interview;Investments;Knowledge;Life Expectancy;Link;low socioeconomic status;Measures;Mediator;Medical;member;Methods;Minority;Minority Groups;Modeling;multi-racial;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Observational Study;Outcome;patient centered medical home;Patient-Centered Care;Patients;Performance;Persons;Policy Maker;preference;Prevalence;Primary Care;psychosocial;Quality of Care;Race;racial difference;racial disparity;racial minority;racial minority population;Research;Resources;Service delivery model;Site;social health determinants;Social Workers;sociodemographics;socioeconomic disparity;Socioeconomic Status;socioeconomics;team-based care;Time;Variant;Veterans;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Mitigating Racial/Ethnic and Socio-Economic Disparities in VA Care Quality and Patient Experience

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Physical Activity;Prevention

ORG_CITY: Aurora

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The goal of this two-site proposal is to determine whether and by what means insulin resistance, in the form of impaired insulin regulation of microvascular perfusion, leads to decreased exercise capacity in men and women with type 2 diabetes. Data from our two research teams suggest that the cardiac and skeletal muscle microvascular dysfunction present in people with T2D contributes to limitations in cardiac and skeletal muscle oxygenation and function associated with impaired function exercise capacity (a major predictor of CV and all cause mortality). Understanding the role of microvascular disease in the diabetes-mediated exercise impairment may offer novel targets for intervention to improve exercise capacity, functional status and longevity in people with diabetes.

PI_NAMEs: LIU, ZHENQI ;REGENSTEINER, JUDITH G.;REUSCH, JANE E (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adult;Attenuated;Blood Vessels;Cardiac;cardiorespiratory fitness;Cardiovascular system;Clinical assessments;clinically significant;Colorado;Complications of Diabetes Mellitus;Data;Development;Diabetes Mellitus;Evaluation;Exercise;exercise capacity;exercise training;experimental study;Functional disorder;Functional impairment;functional status;Goals;Health;heart function;impaired capacity;Impairment;improved;in vivo;innovation;insight;Insulin;insulin regulation;Insulin Resistance;Intervention;Kinetics;Knowledge;Life Style;Longevity;Measures;Mediating;men;Microvascular Dysfunction;Morbidity - disease rate;mortality;Muscle;Muscle Development;Muscle function;Muscle Mitochondria;Myocardium;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Oxygen;Oxygen Consumption;Performance;Perfusion;Persons;pharmacologic;Physical activity;Physical Fitness;Physiological;Premature Mortality;Publishing;remediation;Reporting;Research;Research Methodology;response;Rest;Role;Sex Differences;sex disparity;Site;skeletal;Skeletal Muscle;success;survival prediction;Testing;Therapeutic Effect;therapeutic target;Training;Universities;uptake;Virginia;Woman;Workload;Youth

PROJECT_TITLE: Role of Microvascular insulin resistance and cardiorespiratory fitness in diabetes

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Memory B cells are important for immune defense against influenza infection and for successful vaccination. Influenza-specific memory B cells reside at systemic sites and in the lung, where they provide protection to against infection, however, we do not understand how memory B cells in different locations are related, what their functional properties are or what subsets might be triggered by vaccination. This proposal will define the lineage relationships and functional properties of influenza-specific memory B cells.

PI_NAMEs: RANDALL, TROY D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: Adoptive Transfer;Affinity;Alveolar;Antibodies;Antigens;B cell differentiation;B-Cell Activation;B-cell receptor repertoire sequencing;B-Lymphocyte Subsets;B-Lymphocytes;Bar Codes;Blood;Bronchus-Associated Lymphoid Tissue;Cell Differentiation process;Cell surface;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clone Cells;Cloning;cross reactivity;Data;Deposition;DNA;draining lymph node;experience;experimental study;Genetic Transcription;Home;Immune;Immunity;Immunoglobulin-Secreting Cells;In Situ;Individual;Infection;Influenza;influenza infection;influenza virus strain;Lavage;Location;Lung;lung colonization;lymph nodes;Lymphoid;Lymphoid Tissue;Maps;Memory;Memory B-Lymphocyte;Metabolic;Methods;Molecular Analysis;Mus;Phenotype;Population;progenitor;programs;Property;Publishing;Reaction;Recombinant Antibody;respiratory;Role;secondary infection;Secondary to;single-cell RNA sequencing;Site;Specificity;Spleen;stem cells;Structure of germinal center of lymph node;Structure of parenchyma of lung;Surface;T memory cell;Testing;Time;Tissues;transcriptome;Vaccinated;Vaccination;Vaccine Design

PROJECT_TITLE: Molecular Analysis and Lineage Tracing of Influenza-Specific, Lung-Resident Memory B Cells

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative  Successful ovulation and subsequent corpus luteum formation and development are essential for female fertility. In the present proposal, we will demonstrate for the first time that the FOS/AP-1 transcription factor plays an essential role in ovulation and corpus luteum formation in both humans and mice. Information derived from the present proposal will provide novel insights into the mechanism(s) underlying ovulation and luteal formation and can be applied for promoting and inhibiting the critical facet of ovarian physiology, thereby allowing us to effectively manage fertility in women.

PI_NAMEs: JO, MISUNG  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Ablation;Address;Affect;Albers-Schonberg disease;Binding;Binding Sites;Biological Process;Birth;Cell Culture Techniques;Cells;clinical application;corpus luteum;Data;design;Development;DNA Binding;Event;Exhibits;Family;Family member;female fertility;Fertility;FOS gene;Foundations;Future;Gene Expression;Genes;Gonadotropins;granulosa cell;Hour;Human;Human Chorionic Gonadotropin;human tissue;improved;In Vitro;in vivo;insight;jun Oncogene;JUNB gene;Knockout Mice;Knowledge;Luteinization;Mediating;member;mouse model;Mus;Mutant Strains Mice;novel;Ovarian;Ovarian Tissue;Ovary;Ovulation;Pathway interactions;Phenotype;Physiological;Physiology;Pilot Projects;Play;PMSG (Gonadotropins);prevent;Process;Progesterone Receptors;promoter;Prostaglandins;Reporting;Role;spatiotemporal;System;Time;transcription factor;Transcription Factor AP-1;Transgenic Mice;Woman;women's reproductive health

PROJECT_TITLE: The Role of FOS in the Ovary

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Ewing sarcoma is an aggressive cancer in children, adolescents and adults that is treated with chemotherapy and surgery and/or radiation. The goal of this research to define the mechanistic details of a novel pathway in Ewing sarcoma tumors that has direct clinical translation and can be targeted using FDA-approved drugs.

PI_NAMEs: GORDON, DAVID J (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Adolescent;Adult;Applications Grants;Biological Models;bone;Bone Tissue;Cancer cell line;candidate identification;Cell Line;Cell model;Cells;CHEK1 gene;chemotherapy;Child;Chromosomal translocation;clinical translation;Clinical Trials;cytotoxic;Cytotoxic Chemotherapy;Data;Deoxyribonucleotides;Development;Disease;DNA biosynthesis;DNA Damage;Drug Screening;drug sensitivity;early phase clinical trial;Ewings sarcoma;EWS-FLI1 fusion protein;EWSR1 gene;experimental study;FDA approved;FLI1 gene;gemcitabine;Gene Expression;Gene Expression Profile;Gene Fusion;Generations;Genetic;Goals;high throughput screening;human disease;human embryonic stem cell;Immune checkpoint inhibitor;Impairment;In Vitro;in vivo;in vivo evaluation;inhibitor;innovation;Laboratories;Lead;Libraries;Malignant Childhood Neoplasm;Malignant Neoplasms;Mammalian Cell;Mediator;Modeling;Molecular;Molecular Target;mouse model;Mus;neoplastic cell;Network-based;new therapeutic target;novel;Oncogenes;Oncoproteins;Operative Surgical Procedures;parent grant;Pathogenesis;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;pre-clinical;Protein Biosynthesis;Proteins;Radiation;Regulation;replication stress;Research;Resources;response;Ribonucleotide Reductase;Ribonucleotide Reductase Inhibitor;Role;screening;soft tissue;Soft tissue sarcoma;stem cell model;subcutaneous;synergism;System;targeted treatment;Testing;therapeutic candidate;therapeutic target;Toxic effect;transcription factor;tumor;tumor growth;tumor initiation;tumor progression;tumorigenesis;United States National Institutes of Health;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Gene Expression Signature Based Screening in Ewing Sarcoma


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE This Centers of Biomedical Research Excellence (COBRE) proposal establishes a Center for Rural Health Care Delivery Science at Dartmouth-Hitchcock Health (D-HH), a rural academic health system. The Center will concentrate its efforts on understanding and solving challenges associated with the provision of health care in rural areas, focusing on a community-engaged approach to research. It will also mentor and support a critical mass of early-career clinician-scientists as they transition into independent researchers dedicated to decreasing health care disparities in rural communities.

PI_NAMEs: CREAGER, MARK A (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Academic Medical Centers;access disparities;Accountability;Achievement;Address;advanced analytics;American;Award;Back;care delivery;career;Caring;Centers of Research Excellence;clinical infrastructure;Communities;community based participatory research;community engaged approach;community engaged research;community engagement;Complex;Core Facility;Coupled;Dedications;Detection;Development;digital health;Disease;Disease Management;disorder prevention;end of life care;Ensure;Environment;Equity;Evaluation;Evolution;experience;Face;Faculty;Fostering;Foundations;Funding;Geography;Goals;Health;health care delivery;health care disparity;Health Care Research;health management;Health Policy;Health Services Accessibility;Health system;Health Technology;Healthcare;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Link;member;Mentors;Mentorship;Methodology;Modeling;Monitor;multidisciplinary;nonmetropolitan area;Performance;Phase;Pilot Projects;Policy Maker;poor health outcome;Population;Process;Program Evaluation;programs;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Rural;rural area;Rural Community;rural dwellers;Rural Health Centers;rural health disparities;rural healthcare;rural patients;Rural Population;Science;Scientist;screening;Senior Scientist;skills;Socioeconomic Factors;System;timeline;Training;Translating;United States;Work


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PROJECT_TERMS: Address;Advisory Committees;Area;Attention;authority;career;career development;Cell Nucleus;Centers of Research Excellence;Collaborations;Communication;community engaged research;community partners;Counseling;Coupled;Dedications;Development;Educational Curriculum;Ensure;Equitable healthcare;Evaluation;Faculty;Faculty Recruitment;Feedback;formative assessment;Foundations;Funding;Funding Mechanisms;Goals;Growth and Development function;Health;health care delivery;health care disparity;improved;Individual;Infrastructure;Institution;Interdisciplinary Study;Leadership;Letters;meetings;member;Mentors;Mentorship;Mission;multidisciplinary;National Institute of General Medical Sciences;Occupational activity of managing finances;operation;organizational structure;Phase;Pilot Projects;Process;Program Evaluation;programs;Progress Reports;Qualifying;Research;research and development;Research Personnel;Research Project Grants;Resources;Rural Health Centers;rural healthcare;Rural Population;Science;Scientist;skills;Structure;Study Section;symposium;Teacher Professional Development;Training;Training and Education;Work

PROJECT_TITLE: Administrative & Mentoring (A&M) Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: O'MALLEY, ALISTAIR JAMES (contact)

PROJECT_TERMS: Address;analytical method;Area;Censuses;Characteristics;Clinic;clinical care;Collaborations;Communities;community collaboration;community engagement;Community Outreach;community partners;Complement;Consultations;Data;Data Analyses;Data Collection;data infrastructure;data management;data repository;Data Science;Data Set;Data Sources;data visualization;data warehouse;Dependence;design;Development;Disease;disease registry;Disparity population;diverse data;Electronic Health Record;Ensure;Environment;Feeds;Fostering;Funding;Future;Goals;Health;health care delivery;Health Care Research;health care service;Health Insurance;Healthcare;Heterogeneity;improved;Informatics;Infrastructure;innovation;insurance claims;interest;Interview;Link;Maine;Maps;Measures;Medical center;Methodology;Methods;Modeling;Nature;New England;New Hampshire;novel;Pathway Analysis;Persons;Population;practice-based research network;primary care practice;Qualitative Methods;Reporting;repository;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Rural Community;Rural Health;Rural Health Centers;rural healthcare;rural patients;Rural Population;Sample Size;Science;Scoring Method;Services;social health determinants;Social Network;Source;Statistical Methods;Statistical Models;statistics;Structure;Surveys;System;Time;Vermont;Visualization;Work

PROJECT_TITLE: Statistics, Informatics & Qualitative Methods (SIQM) Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative (Public Health Relevance Statement) Copper is an essential metal nutrient that is required for physiological functions spanning respiration and metabolism to antioxidant defense. Loss of copper homeostasis resulting from a combination of genetics, environment, diet, and lifestyle is connected to diseases including cancer, heart and neurodegenerative diseases, and metabolic disorders like obesity and diabetes. We are developing new chemical reagents for copper imaging and proteomics in biological systems to help decipher how copper contributes to healthy and disease states and target copper-dependent disease vulnerabilities, focusing on the contributions of copper and oxidative stress in cancer.

PI_NAMEs: CHANG, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: activity-based protein profiling;Animal Model;Animals;Antioxidants;Binding;Biochemical;Biological;Biological Models;biological systems;Biology;bioluminescence imaging;Cell model;Cell Proliferation;Cells;Chemicals;chemoproteomics;Complex;Copper;Cysteine;design;Detection;Development;Diabetes Mellitus;Diet;Disease;Environment;Enzymes;Evaluation;Fluorescence;Fluorescent Probes;Genetic;Health;Heart Diseases;Homeostasis;hormone biosynthesis;Human;Image;imaging agent;imaging modality;imaging probe;In Vitro;in vivo;inhibitor;innovation;invention;Label;Lead;lead candidate;Life Style;Logic;luminescence;Malignant Neoplasms;Maps;Melanoma;Metabolic;Metabolic Diseases;Metabolism;Metals;Methods;Modality;Modeling;Monitor;Neurodegenerative Disorders;neurotransmitter biosynthesis;next generation;Noise;novel;Nutrient;Obesity;Oncogenes;Optics;Organelles;Output;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathology;Pathway interactions;Physiological;Physiological Processes;Physiology;Play;Prognosis;protein purification;Proteins;Proteomics;proteostasis;public health relevance;Puromycin;Reagent;receptor;Research;Research Personnel;Resolution;Respiration;Role;Sampling;screening;Signal Transduction;Site;Specificity;Stains;Structure;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Visualization

PROJECT_TITLE: Chemical Probes to Study Copper Biology

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Five and a half million Americans are being robbed of their functioning brains by Alzheimer’s Disease (AD), without benefit of any drug to halt their decline into dementia. To develop effective drugs, we take the approach that has been effective for treating cancer and HIV-AIDS: structure-based drug design. Applying the powerful tools of electron microscopy and x-ray diffraction, we learn the atomic structures of the toxic aggregates believed to trigger AD, and then knowing the placement of atoms, design drugs that interfere with formation of these aggregates, disaggregate them, and inhibit their toxic spread throughout the brain.

PI_NAMEs: EISENBERG, DAVID  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: 3-Dimensional;abeta oligomer;Address;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease test;American;Amyloid beta-Protein;amyloid structure;Amyloidosis;Antibodies;Autopsy;Brain;brain behavior;cell type;Cells;Collaborations;Complex;Cryoelectron Microscopy;cytotoxic;Data Collection;Dementia;design;Development;Disease;Drug Binding Site;drug candidate;Drug Design;drug testing;efficacy evaluation;electrical property;Electron Microscopy;Epigallocatechin Gallate;Etiology;Exhibits;frontier;Frustration;HIV/AIDS;Human;improved;inhibitor;Knowledge;Learning;Ligands;Malignant Neoplasms;mouse model;Mus;nanoparticle;Nature;Negative Staining;Nerve Degeneration;Organoids;Pathology;Pharmaceutical Preparations;pharmacophore;Property;protein aggregation;Proteins;reconstruction;Research Personnel;Resolution;Science;screening;small molecule;Structure;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;tool;Vacuum;Work;X ray diffraction analysis

PROJECT_TITLE: Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Rural Health;Social Determinants of Health

PI_NAMEs: BRUCE, MARTHA L (contact)

PROJECT_TERMS: Address;Advocacy;Advocate;Aging;aging population;burden of illness;career;Caregivers;Centers of Research Excellence;Collaborations;Communication;Communities;community engaged research;community engagement;Community Health;Community Outreach;community research;Consultations;data library;design;Development;Educational Curriculum;Elements;Environment;Equity;experience;Funding;Goals;Health;health care availability;health care delivery;Health Personnel;Health Priorities;Health system;hospice environment;improved;innovation;Lead;Leadership;Learning Skill;meetings;member;Methodology;Mission;Needs Assessment;New England;novel strategies;online community;Online Systems;outreach;participant retention;Patient Recruitments;Patients;Phase;Policy Maker;Population;population health;Population Heterogeneity;Poverty;practice-based research network;Primary Care;primary care practice;Process;programs;Research;Research Design;Research Personnel;Resources;retention rate;Rural;rural area;Rural Community;Rural Health;Rural Health Centers;Rural health equity;Rural Health Services;rural healthcare;Rural Population;rural setting;Science;Scientist;Services;Testing;Trainers Training;Training;United States National Institutes of Health;virtual

PROJECT_TITLE: Community Engagement & Outreach (CEO) Core


NIH_SPENDING_CATS: Aging;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Primary Health Care;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: ZEITLER, EMILY  (contact)

PROJECT_TERMS: Academic Medical Centers;Achievement;Address;Age;American;Area;Arrhythmia;cardiac implant;Cardiovascular system;care delivery;care outcomes;Caring;Case Study;Cellular Phone;Characteristics;Client satisfaction;Clinical;community engagement;Community Outreach;Consensus;cost;Country;Data;Defibrillators;Devices;digital divide;digital health;Disease Progression;Disparity;Early Intervention;Economics;Elderly;Electronics;Eligibility Determination;Equilibrium;ethnic minority population;Evaluation;experience;Face;geographic difference;geographic disparity;Geographic Distribution;Geography;Guidelines;health care delivery;health care disparity;Health care facility;Health Insurance;Health Technology;Healthcare;Home;Hospital Referrals;Hospitals;Implant;Implantable Defibrillators;implantable device;improved;improved outcome;Informatics;Infrastructure;Inpatients;Institution;Internet;Intervention;Interview;Lead;Longevity;Manufacturer;Measures;Medical;medical specialties;Medicare;Medicare claim;Methods;Monitor;monitoring device;mortality;older patient;Outcome;Pacemakers;Pathway Analysis;Patient Monitoring;Patients;Pattern;Performance;Periodicals;Persons;Physicians;Policy Maker;Population;population based;Positioning Attribute;preference;Prevalence;Primary Care Physician;Provider;Qualitative Methods;Qualitative Research;racial minority population;Recommendation;remote monitoring;remote patient monitoring;Reporting;Research;Research Methodology;Research Personnel;Resources;Rural;rural area;Rural Health Centers;rural patients;rural setting;rurality;Science;Services;Site;Speed;statistics;Structure;Surveys;System;Travel;Uninsured;uptake;Variant;wireless;Work

PROJECT_TITLE: Identifying Disparities in Care of Rural Patients with Cardiac Implantable Electronic Devices


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Project Narrative With the development of proteolysis targeting chimeras (PROTACs), a new dimension in drug discovery has emerged. This project proposes to develop and test novel cancer therapeutic PROTACs aimed at targeting the PD-L1 receptor protein, thus infringing upon tumor inhibition of T-cell activation which is a common immune evasion strategy of many cancer types. Conclusions drawn from this study will provide important preliminary insight as to whether PROTACs that recruit extracellular E3 ubiquitin ligases can be utilized to induce degradation of cancer-associated membrane proteins, thereby showcasing a new frontier in oncological drug discovery research.

PI_NAMEs: COLEMAN, DEMONTA  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Affinity;Antineoplastic Agents;Bacteriophages;Binding;Biological Assay;Biotinylation;Cancer cell line;cancer therapy;cancer type;CD44 gene;cell growth regulation;Cell Line;Cells;Clinical Trials;Consensus;Consensus Sequence;Cyclic Peptides;Cyclization;Dependence;design;Detection;Development;Dimensions;Docking;Drug Design;drug development;drug discovery;Enzymes;Epitopes;Escherichia coli;Event;extracellular;Extracellular Domain;Flow Cytometry;frontier;High Pressure Liquid Chromatography;Immobilization;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immune Targeting;immunoregulation;In Vitro;in vivo;Incubated;innovation;insight;Kinetics;Large Intestine Carcinoma;Length;Libraries;Ligand Binding;Ligands;Literature;Lysosomes;Malignant Neoplasms;MDA MB 231;Medicine;member;Membrane;Membrane Proteins;Methods;Modeling;Molecular;multicatalytic endopeptidase complex;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;Oncology;Organic Synthesis;overexpression;Pathway interactions;PD-1/PD-L1;PDL1 pathway;Peptide Synthesis;Peptides;Phage Display;pharmacologic;Phase;Polyethylene Glycols;Polyubiquitination;Positioning Attribute;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Protac;protein aminoacid sequence;protein degradation;Proteins;Proteomics;receptor;Recombinants;recruit;Reporting;Research;Research Personnel;Residual state;Resolution;Route;SARS-CoV-2 spike protein;small molecule;Solid;Streptavidin;Structure;Structure-Activity Relationship;Surface;System;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;triple-negative invasive breast carcinoma;tumor;Ubiquitin;ubiquitin-protein ligase;Western Blotting;Work

PROJECT_TITLE: Development of PD-L1 Proteolysis-Targeting Chimeras (PROTACs): An Innovative Cancer Drug Discovery Route


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CALI

ORG_COUNTRY: COLOMBIA

ORG_FIPS: CO

ORG_NAME: CENTRO INTERNACIONAL  (CIDEIM)

PHR: NARRATIVE Historically, Colombia has been a focal point of tropical and infectious disease research. The post-conflict strategy of the government of Colombia has prioritized development and improvement of health in rural areas impacted by over 5 decades of conflict. Communities in these areas are among the most affected by leishmaniasis and other vector-borne and emerging infectious diseases and have chronically limited access to healthcare. This training program will prepare a cohort of new investigators in CIDEIM and other Colombian institutions and strengthen their research and training capacity to enable the implementation of the results of research on these diseases, into practice.

PI_NAMEs: GORE SARAVIA, NANCY  (contact);TSCHUDI, CHRISTIAN

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: base;Basic Science;career development;Clinical;Clinical Research;Colombia;Colombian;Communicable Diseases;Communication;Disease;Educational Curriculum;Educational workshop;Emerging Communicable Diseases;Faculty;Funding;Goals;Health Sciences;implementation research;implementation science;Infectious Diseases Research;innovation;Institution;inter-institutional;Intervention;Latin American;Leadership;Leishmaniasis;low and middle-income countries;Mentors;Mentorship;Online Systems;Prevention;programs;public health research;Research;Research Personnel;Research Training;synergism;Technology;Training;Training Programs;Translational Research;Universities;vector-borne

PROJECT_TITLE: Integration of Translational and Implementation Research Training on Leishmaniasis and other Vector-borne and Emerging Infectious Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Malaria;Nutrition;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Morbidity of SARS-CoV-2 in Malawi and other sub-Saharan African countries have been lower than elsewhere in the world. One possible explanation is the high prevalence of infectious diseases such as malaria and helminthiasis that can elicit immunity that may affect susceptibility to progression of SARS-CoV-2; the same factors may influence immunity induced by SARS-CoV-2 vaccines. Understanding the epidemiology for SARS- CoV-2, as well as the population immunological substrate in countries like Malawi will be important to define cost-effective SARS-CoV-2 vaccination policies to the region.

PI_NAMEs: BEESON, JAMES ;HIBBERD, PATRICIA L;MATHANGA, DON P;VALIM, CLARISSA  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Acute;adaptive immune response;Adult;Affect;Africa South of the Sahara;African;age difference;Age Distribution;American;Americas;Anemia;Anti-viral Response;Antibodies;Antibody Response;Antibody-mediated protection;assault;B-Lymphocytes;booster vaccine;Cells;chemokine;Childhood;Chronic;Collaborations;Communicable Diseases;comorbidity;cost effective;Country;COVID-19 morbidity;COVID-19 mortality;COVID-19 susceptibility;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Death Rate;design;Disease;Disease Progression;Effectiveness;Enrollment;Epidemiology;Europe;Exhibits;Exposure to;Frequencies;Health;Helminthiasis;High Prevalence;high risk;Household;Immune;immune activation;Immunity;Immunization Programs;Immunologics;Impairment;improved;indexing;Individual;Infection;infection risk;Inflammatory;Innate Immune Response;Innate Immune System;Interferon Type I;Intestinal parasite;Longevity;Macrophage;Malaria;malaria infection;Malawi;Malnutrition;Memory B-Lymphocyte;monocyte;Morbidity - disease rate;mortality;Natural Immunity;pandemic disease;Parasitic infection;Participant;pathogen;Pathogenesis;Phenotype;Policies;Population;Predisposition;programs;progression risk;Regimen;respiratory virus;response;Risk;SARS-CoV-2 B.1.617.2;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 transmission;seroconversion;serosurvey;Social Behavior;Symptoms;Testing;Time;Training;transmission process;Universities;Vaccination;vaccination outcome;vaccine hesitancy;Vaccinee;Vaccines;Viral;Viremia;Virus;Work

PROJECT_TITLE: COVID Transmission and Morbidity in Malawi (COVID-TMM)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(02)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN BERNARDINO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CALIFORNIA STATE UNIV SAN BERNARDINO

PHR: Narrative - Relevance The future of the nation's biomedical research workforce depends on the continued development of well-trained undergraduates who seek Ph.D. degrees in the biomedical and behavioral sciences. The next generation of researchers will increasingly be made up of underrepresented students who historically have not pursued such career goals. This project seeks to attract and prepare such students to meet this national need.

PI_NAMEs: CRAWFORD, CYNTHIA A. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Biomedical Research;California;career;experience;faculty mentor;Goals;Institution;Mentors;Mission;Motivation;peer coaching;Positioning Attribute;programs;Research;Science;STEM field;Students;success;supplemental instruction;Training;tutoring;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at California State University San Bernardino

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This project proposes to assemble the largest biomarker cohort of African Americans for Alzheimer disease (AD) by leveraging on both the existing biomarker samples and data from five major biomarker studies of AD and prospectively collected biomarker samples and imaging scans from these studies. The potential racial disparity in molecular biomarkers of AD, as well as in their predictability to subsequent cognitive outcomes, if confirmed by the proposed study on the largest AA biomarker cohort, may imply differential treatment responses between races, and hence will have profound implications to the design and analyses of ongoing and future prevention and treatment trials of AD.

PI_NAMEs: XIONG, CHENGJIE  (contact)

PROGRAM_OFFICER_NAME: ELLIOTT, CERISE

PROJECT_TERMS: African American population;Age;aging brain;Alzheimer's Disease;Alzheimer's Disease Core Center;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Apolipoprotein E;Area;asymptomatic Alzheimer's disease;Biological Markers;Blood Vessels;Body mass index;Caucasians;Cerebrospinal Fluid;Clinical;Clinical Trials;Cognition;Cognitive;cognitive change;cohort;Data;Data Set;Databases;Dementia;deprivation;design;Disease;Education;efficacious treatment;Family;Family history of;Future;Genotype;Glycosylated hemoglobin A;Goals;healthy aging;Hippocampus;Image;indexing;Lead;Literature;Longitudinal Studies;Magnetic Resonance Imaging;mild cognitive impairment;Modality;molecular marker;Multicenter Studies;Nature;Outcome;Participant;Pennsylvania;Persons;Phosphorylation;Play;Population Heterogeneity;Positron-Emission Tomography;pre-clinical;Prevention trial;prospective;Protocols documentation;Publishing;Race;racial difference;racial disparity;rate of change;Recording of previous events;Research;Risk Factors;Role;Sample Size;Sampling;Scanning;sex;Socioeconomic Status;Standardization;Statistical Models;structural imaging;tau Proteins;Tracer;treatment response;treatment trial;Underrepresented Populations;Universities;uptake;Washington;White Matter Hyperintensity;Work

PROJECT_TITLE: Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of Alzheimer Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Fetal Tissue;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE We propose to use state of the art bioengineering to model the 3D laminar circuit of the human cerebellum, growing human pluripotent stem cell-derived cerebellar Purkinje cells and granule neurons in layers on glass wafers and defining their functional connectivity and transcriptome vs native tissue. We will then develop the first protocols to differentiate unipolar brush cells to modulate the circuit. This platform will prove invaluable for modeling human cerebellar function and dysfunction as well as for drug discovery.

PI_NAMEs: HATTEN, MARY ELIZABETH;MILLEN, KATHLEEN JOYCE (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Address;Algorithms;Architecture;Area;ATAC-seq;Biological Assay;Biomedical Engineering;Brain;Brain region;Brush Cell;Calcium;calcium indicator;Calcium Spikes;Cell Density;Cell Nucleus;cell type;Cells;cellular imaging;Cerebellar Cortex;Cerebellum;Cognition;comparative;Cytoplasmic Granules;Data Set;design;Development;Diameter;differentiation protocol;disease model;drug discovery;Drug Screening;Emotions;experimental study;fetal;Functional disorder;Gene Expression;Gene Expression Profile;Genetic Transcription;Glass;Glutamates;granule cell;Human;human model;human pluripotent stem cell;Image;In Vitro;in vivo;Interneurons;Language;Light;Lip structure;Methodology;Methods;Microscopy;Modeling;motor control;neuronal circuitry;Neurons;novel;novel therapeutics;optogenetics;Organoids;Pharmacotherapy;progenitor;Property;Protocols documentation;Purkinje Cells;redshift;Reproducibility;Research;Rhodopsin;RNA;Scanning;self organization;sensor;Sensory;Signal Pathway;single cell analysis;single cell ATAC-seq;single-cell RNA sequencing;Sorting;Structure;System;Testing;Thick;three dimensional cell culture;three-dimensional modeling;Tissues;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics

PROJECT_TITLE: A Bioengineering Approach to Develop a Laminar 3D Cerebellar Neuronal Circuit for Modeling Human Cerebellum

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LOUISVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

PHR: Project Narrative This multi-PI project focuses on the role of the long ascending and descending propriospinal neurons (LAPNs, LDPNs) in the control of locomotion and recovery after a spinal cord injury. We will use a combination of viral based synaptic silencing, retrograde and trans-synaptic tracing and comprehensive gait and kinematic analysis to aid the development of a neuro-biomechanical computer model and to generate important new knowledge of spinal locomotor circuitry.

PI_NAMEs: DANNER, SIMON MICHAEL;MAGNUSON, DAVID SK (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Anatomy;animal data;Animals;Axon;Behavior;Binding;biomechanical model;Biomechanics;central pattern generator;Cervical;Characteristics;Computer Models;Computer Simulation;Contusions;Data;Data Set;design;Development;Dissection;Experimental Models;experimental study;Forelimb;Gait;Goals;Hindlimb;in silico;in vivo;Injury;Interneurons;Ipsilateral;kinematics;Knowledge;Label;Lateral;Left;Limb structure;Locomotion;Mediating;model development;Modeling;Molecular;Movement;Musculoskeletal System;neural circuit;Neurons;neurotransmission;novel;novel therapeutics;Physiological;Play;Population;predictive modeling;Publishing;Rattus;Recovery;Reverse engineering;Role;Running;Sensory;sensory input;Source;Speed;Spinal;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Structure;Structure-Activity Relationship;Synapses;Techniques;Testing;Thoracic spinal cord structure;tool;Validation;Viral;Virus;Walking

PROJECT_TITLE: Propriopsinal neuron function in normal and post-SCI locomotion

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Nutrition;Pediatric;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Toddler milk, an ultra-processed milk-based drink recommended for children ages 9-36 months, often contains added sugar in its composition as well as scientifically unsupported marketing claims on the front-of-package (FOP) label. Research is urgently needed about parents’ understanding of toddler milk FOP claims, and this study will directly fill this gap by examining how toddler milk marketing influences parental perceptions and beliefs via a systematic review, packaging content analysis, and focus groups with parents. Contributing scientific evidence related to the food industry's marketing practices of toddler milk and how they affect parents' beliefs and perceptions of the product could inform the FDA and policymakers, informing future regulation of toddler milk packaging.

PI_NAMEs: CARDOSO RICHTER, ANA PAULA  (contact)

PROGRAM_OFFICER_NAME: BROCKWAY, HEATHER MARIE

PROJECT_TERMS: Adult;Affect;Age;aged;Americas;authority;Behavior;Belief;Beverages;Brain;Cardiovascular Diseases;Characteristics;Child;Child Health;Childhood;Code;cognitive development;Collaborations;Communication;Complex;Consumption;Country;critical developmental period;critical period;Data;Data Analyses;Databases;Development;Diagnosis;Diet;Dietary Practices;Disease;early childhood;early-life nutrition;Elements;Ethnic Origin;Expenditure;Exposure to;Faculty;feeding;Focus Groups;Food;Food Industry;Food Labeling;Frequencies;Future;Goals;good diet;Guidelines;Health Food;heuristics;Image;Immunity;improved;Industry;Intervention;Knowledge;Label;Latin America;Latin American;Latino;Latinx;Librarians;Life Cycle Stages;Literature;Marketing;Medical;member;Meta-Analysis;Milk;Mission;National Institute of Child Health and Human Development;Non-Insulin-Dependent Diabetes Mellitus;Nutrition Policy;Nutritional;Obesity;parent grant;parental influence;Parents;Perception;Phase;Policies;Policy Maker;Powder dose form;Prevalence;prevent;Printing;Process;Protocols documentation;Public Health;Reaction;Recommendation;Regulation;Reporting;Research;Research Personnel;Risk;Sales;Science;skills;Source;Statutes and Laws;sugar;sweetened beverage;systematic review;tenure track;therapy development;Time;Toddler;Training;Training Activity;Translating;United States;United States Food and Drug Administration;Work;World Health Organization

PROJECT_TITLE: "Examining Marketing and Parents’ Perceptions of Toddler Milk”

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Maternal Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: Project Narrative Neighborhoods that experienced historical segregation and community-level disinvestment based on decades of discriminatory race-based policies rooted in racism have infant mortality rates (IMR) that are over 20 deaths per 1,000 live births (2%) with racial disparity ratios nearing three. The objective of this proposal is to describe historical and contemporary discriminatory policies influencing IMR and other maternal and child health experiences and outcomes across generations of Black women and importantly, demonstrate how community re-investment can be designed to target and rectify historic and contemporary structural racism and discrimination.

PI_NAMEs: CHISOLM, DEENA  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: African American population;Birth;Black Populations;Black race;black women;Caring;Cessation of life;Child;Child Welfare;Cities;Communities;Community Developments;community partnership;Complex;Death Rate;design;Developed Countries;Discrimination;Disparity;Economic Development;Economic Factors;Education;Environmental Risk Factor;Equipment and supply inventories;experience;Family;federal poverty level;food insecurity;formative assessment;Generations;Geography;Goals;Health;health care availability;health care delivery;health disparity;Health Food;health inequalities;Housing;housing instability;implementation evaluation;improved;Inequity;Infant Health;Infant Mortality;innovation;Interview;Investments;lens;Life Cycle Stages;life span;Link;Live Birth;Low Birth Weight Infant;Maps;Maternal and Child Health;Maternal Health;Measures;Medical;Minority;Modeling;multidisciplinary;Neighborhoods;Not Hispanic or Latino;Ohio;Outcome;Pediatric Hospitals;Personal Satisfaction;Persons;Phase;Policies;Population;Poverty;Pregnancy;premature;prenatal;primary outcome;Probability;Race;racial disparity;racism;Recording of previous events;Reproductive Health;Research;Research Personnel;Resources;Risk Factors;Science;segregation;Side;social;social factors;social health determinants;Societies;Stress;Structural Racism;Structure;Sum;System;theories;Tilia;Time;Time Study;Woman;Work

PROJECT_TITLE: Targeted Investment and Meaningful Engagement to Improve MCH Outcomes and Rectify Historical Structural Racism: The TIME Study


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Genetics;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality in the US and worldwide. Mucus hypersecretion and tissue damage in COPD contribute to severe airflow obstruction and death, but they are not effectively treated. This proposal aims to identify mechanisms of how excessive mucus contributes to tissue destruction, and whether disruption of mucus production is protective in COPD.

PI_NAMEs: HU, YAN  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Affect;airway epithelium;airway inflammation;airway obstruction;Alveolar;alveolar destruction;alveolar type II cell;Anatomy;Bioinformatics;Biological Assay;Biology;Bronchioles;Bronchitis;career;career development;Cause of Death;Cells;Cessation of life;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;Clinical;Data;Development;Diameter;differentiation in vitro;Disease;disease model;Disease Progression;Distal;Elements;Environment;Epithelial Cells;epithelial stem cell;Epithelium;Etiology;Family suidae;Foundations;Functional disorder;Gel;Gene Expression Profiling;Genes;Genetic;Goals;Health;Homeostasis;Human;Impairment;improved;in vivo;Inflammation;interest;Knowledge;Label;Learning;Link;Lung;lung development;lung repair;Maintenance;Mentors;Molecular Analysis;mortality;mouse model;MUC5B gene;Mucins;Mucous body substance;mucus hypersecretion;Mus;Natural regeneration;novel;novel therapeutics;Obstruction;Organoids;overexpression;Pancreatic Elastase;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Phase;Phenotype;Polymers;Positioning Attribute;prevent;primary endpoint;Production;progenitor;Publishing;Pulmonary Emphysema;pulmonary function;Regulator Genes;repaired;Research;Research Personnel;Secretory Cell;Signal Pathway;single-cell RNA sequencing;small airways disease;stem cell expansion;stem cell function;stem cells;Structure;Symptoms;Tamoxifen;Terminal Bronchiole;Testing;tissue repair;Tissues;Training;Transgenic Organisms;translational study;Veins;X-Ray Computed Tomography

PROJECT_TITLE: Molecular Analysis of Airway Secretory Cells in Health and Disease

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Precision Medicine;Prevention;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Women in two weight loss interventions changed their behavior overtime. We will assess how the environment around them may have affected their behaviors to inform future studies that use spatial cues to prompt behavior change.

PI_NAMEs: BENMARHNIA, TARIK  (contact);JANKOWSKA, MARTA

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Accelerometer;active lifestyle;adaptive intervention;Address;Advocacy;Affect;Age;Aging;Air Pollution;Automobile Driving;Behavior;behavior change;behavior influence;behavior prediction;Behavioral;Big Data Methods;Biological Markers;Body mass index;Body Weight decreased;Breast Cancer Risk Factor;Breast Cancer survivor;built environment;Businesses;cancer biomarkers;Cancer Center;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Cessation of life;Characteristics;Cluster Analysis;Communities;community partners;connected care;Cues;Data;Data Analyses;data integration;demographics;design;Disparity;Elderly;Environment;environmental change;Environmental Exposure;Environmental Risk Factor;Equity;Exposure to;Food;food environment;frailty;Funding;Future;Glucose;Goals;Government;Green space;Health;health assessment;Health Food;High Risk Woman;Home;Home environment;hospital readmission;improved;Individual;Individual Adjustment;Inflammation;Insulin;Intervention;intervention participants;Learning;lifestyle intervention;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Measures;Methods;mHealth;Modeling;Monte Carlo Method;mortality;Movement;multilevel analysis;National Institute of Environmental Health Sciences;Neighborhoods;novel;Obesity;Outcome;Oxidative Stress;Pathway interactions;Pattern;personalized approach;personalized medicine;Physical activity;Policies;Pollution;Population;Population Group;prediction algorithm;predictive modeling;prevent;programs;Psychosocial Factor;Recommendation;Recording of previous events;remote group;remote location;Research;Resources;Risk;Sampling;social media;Source;Standardization;Surgeon;Surveys;Techniques;Technology;Testing;Time;Transportation;unsupervised learning;Vitamin D;walkability;Walking;weight loss intervention;Woman;Women's trial

PROJECT_TITLE: Integrating novel GIS and GPS data to assess the impact of built environments on changes in BMI, physical activity and cancer-related biomarkers in two successful weight loss interventions in women at


ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: OVERALL: DIRECTOR'S OVERVIEW & SIX ESSENTIAL CHARACTERISTICS  PROJECT NARRATIVE The Chao Family Comprehensive Cancer Center (CFCCC) of the University of California, Irvine (UCI) is the only academic cancer center based in Orange County, the sixth most populous county in the United States with over 3.2 million residents who embody substantial socioeconomic and racial/ethnic diversity. Designated as a comprehensive cancer center by the National Cancer Institute since 1997 and backed by the research enterprise of UCI, a member of the Association of American Universities, the CFCCC carries out research across the spectrum of cancer including fundamental mechanisms of cancer development, novel modes of detection and imaging, new anti-cancer drugs and devices, and cancer susceptibility, prevention and survivorship. Through its research programs and supporting resources, the CFCCC translates these discoveries through the pipeline into clinical treatments and interventions that are directed specifically towards reducing the burden of cancer on the multi-ethnic population of Orange County and surrounding areas, and advances this new knowledge onto a wider stage to change clinical cancer practice across the country.

PI_NAMEs: VAN ETTEN, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: American;anti-cancer research;Area;Asian population;biobehavior;Biological Sciences;Biology;Biomedical Engineering;biomedical referral center;Biostatistics Shared Resource;Biotechnology;Businesses;California;Cancer Burden;cancer cell;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Cancer Control;Cancer Patient;cancer survival;Cancer Survivor;cancer therapy;care providers;Caregivers;Catchment Area;Cellular biology;Characteristics;Chemicals;Clinical;Clinical Cancer Center;clinical care;Clinical Data;clinical investigation;clinical practice;Clinical Protocols;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;Communication;Communities;community based research;community engagement;Community Hospitals;Community Outreach;Complex;Comprehensive Cancer Center;computer science;Consultations;Country;County;data management;Detection;Development;Devices;Diagnosis;Discipline;Discipline of Nursing;Disease;drug development;Education;Engineering;Ensure;ethnic diversity;Ethnic Population;Extramural Activities;Family;Funding;Generations;Genitourinary system;Genomics;Goals;Gynecologic Oncology;Health;health disparity;Health Policy;Hematologic Neoplasms;Hematology;Hispanic Populations;Home;Image;improved;in vivo;Information Sciences;Infrastructure;Institution;instrumentation;Intervention;investigator-initiated trial;Journals;Knowledge;Leadership;Lifting;Link;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant neurologic neoplasms;medical schools;Medicine;member;Mission;Monitor;Movement;multi-ethnic;multidisciplinary;nanomedicine;National Cancer Institute;National Center for Advancing Translational Sciences;NCI Center for Cancer Research;NCI-Designated Cancer Center;Neighborhoods;next generation;novel;novel anticancer drug;Oncology;Optics;Oranges;Outcome;Parents;Pathogenesis;Pathway interactions;Patient Care;patient oriented;Patients;Peer Review;Persons;Pharmacologic Substance;Pharmacy facility;Phase;physical science;Policies;Population;population based;population health;Population Sciences;Predisposition;prevent;Prevention;primary care provider;Program Sustainability;programs;Protocols documentation;Provider;public education;Public Health;Public Policy;Publications;Publishing;Race;racial diversity;Refractory;Relapse;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Science;Scientist;Scourge;Services;Sister;Skin Cancer;socioeconomics;Strategic Planning;survivorship;System;Systems Biology;Technology;tissue resource;Training;Training and Education;Transgenic Mouse Facility;Translating;Translational Research;Translations;United States;Universities;University of California Irvine Cancer Center;Vision;Work

PROJECT_TITLE: Cancer Center Support Grant


NIH_SPENDING_CATS: Cancer;Prevention

PHR: CANCER CENTER ADMINISTRATION  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PROJECT_TERMS: Accounting;Advanced Malignant Neoplasm;anti-cancer research;Applications Grants;authority;Basic Science;Budgets;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer research center director;cancer therapy;Catchment Area;Clinical Cancer Center;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;community engagement;Community Outreach;Comprehensive Cancer Center;Contracts;cost;County;data management;Data Reporting;Decision Making;Diagnosis;Discipline;Disease;Education;Educational process of instructing;Ensure;Etiology;Expenditure;Faculty Recruitment;Family;Fostering;Funding;Goals;healing;Infrastructure;Institution;Institutional Policy;Knowledge;Leadership;Malignant Neoplasms;Mediation;Medicine;meetings;Mission;Monitor;Oranges;Parents;Patient Care;Persons;Pilot Projects;Play;Population Sciences;prevent;Prevention;Process;programs;Protocols documentation;Reporting;Research;Research Infrastructure;Resource Sharing;Resources;Review Committee;Role;Strategic Planning;Stream;Training and Education;Translational Research;Vision;Work

PROJECT_TITLE: Administration


NIH_SPENDING_CATS: Cancer

PHR: CANCER RESEARCH TRAINING & EDUCATION COORDINATION  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: NELSON, EDWARD L. (contact)

PROJECT_TERMS: Achievement;Address;Advanced Development;African;American;American Cancer Society;anti-cancer;anti-cancer research;Award;Basic Science;Black race;California;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer education;Cancer Research Project;Cancer Science;career;career development;Career Mobility;Caribbean region;Catchment Area;Chalk;Clinical;Clinical Cancer Center;clinical care;clinical development;Clinical Investigator;Clinical Oncology;Clinical Research;Clinical Sciences;clinical training;college;Communities;community engagement;Community Healthcare;Community Outreach;Comprehensive Cancer Center;Continuing Education;Development;Discipline;Dreams;Education;education research;Educational process of instructing;Elements;ethnic diversity;Ethnic Origin;experience;Exposure to;Extramural Activities;Faculty;Family;Fellowship;First Generation College Students;Fostering;Funding;Future;gender diverse;Goals;graduate student;Grant;healing;Health;Health Personnel;Health Professional;Health Sciences;Healthcare;High School Student;Infrastructure;innovation;Institution;Investments;K-Series Research Career Programs;Latino;Leadership;Malignant Neoplasms;Medical;Medical Education;Medical Students;Medicine;member;Mentors;Mentorship;Mission;Modeling;NCI Center for Cancer Research;next generation;Patient Care;Pattern;Peer Review;peer support;Pilot Projects;Population;Population Sciences;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;Productivity;Program Development;programs;Quality of Care;Research;research and development;Research Personnel;Research Support;Residencies;Resources;Scholars Program;Schools;Sister;skills;socioeconomic diversity;Structure;Students;Training;Training Activity;Training and Education;Training Programs;Training Support;Translational Research;translational scientist;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;University of California Irvine Cancer Center

PROJECT_TITLE: Cancer Research Training and Education Coordination


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PORTLAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: FAIR, DAMIEN A;HUBER, REBEKAH S;NAGEL, BONNIE J (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU


ORG_CITY: PHILADELPHIA

ORG_NAME: NRG ONCOLOGY FOUNDATION, INC.

ORG_STATE: PA

PHR: NRG Oncology seeks to improve the lives of adult patients with gender-specific malignancies (breast, gynecologic, prostate cancers) and/or localized or locally advanced cancer through the development and conduct of a portfolio of timely and relevant clinical trials. NRG uniquely focuses on this large and relatively under-investigated group of cancer patients and has extraordinary scientific accomplishments specific to the group's three specific aims. NRG actively assists in the management of the NCI - National Clinical Trial Network (NCTN) and collaborates with the other NCTN partners in the overall conduct of all NCTN trials.

PI_NAMEs: LE, QUYNH-THU XUAN;MANNEL, ROBERT S.;WOLMARK, NORMAN  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Adult;advanced disease;advanced prostate cancer;African ancestry;Area;Awareness;Brain Neoplasms;Breast;Cancer Patient;Cancer Therapy Evaluation Program;Clinical Research;Clinical Trials;clinically relevant;cohort;Collaborations;design;Development;Disease;Enrollment;Ensure;Gender;Goals;Gynecologic;Head and Neck Cancer;Hispanic;improved;interest;International;Latino;Lead;Leadership;Locally Advanced Malignant Neoplasm;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuscripts;member;multidisciplinary;National Clinical Trials Network;Non-Hematologic Malignancy;Oncology;operation;participant enrollment;patient population;Patients;Peer Review;Positioning Attribute;Precision medicine trial;Protocols documentation;Publishing;Research;Sarcoma;Scientific Advances and Accomplishments;Site;Translational Research;trial enrollment

PROJECT_TITLE: NRG Oncology Network Group Operations Center


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: WOLMARK, NORMAN  (contact)

PROJECT_TERMS: Address;Adult;Advisory Committees;Biological Specimen Banks;Cancer Patient;Clinical Trials;cohort;Collaborations;Data Coordinating Center;Development;experience;Fostering;Goals;improved;Infrastructure;Lead;Leadership;member;Mentors;Mission;Modeling;Modernization;National Clinical Trials Network;Oncology;operation;organizational structure;Population;Productivity;programs;remote monitoring;Research;Site;statistics;success


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: BIOTECHNOLOGY, IMAGING AND DRUG DEVELOPMENT PROGRAM  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: GANESAN, ANAND K (contact)

PROJECT_TERMS: angiogenesis;Animal Model;anti-cancer;anti-cancer research;Antibodies;antibody immunotherapy;Artificial Intelligence;Basic Science;Biological Models;Biology;Biomedical Engineering;Biophotonics;Biotechnology;Breast Cancer Detection;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer radiation therapy;cancer recurrence;cancer therapy;Catchment Area;Cells;Chemicals;Chemistry;circulating biomarkers;Clinic;clinical practice;Clinical Trials;Clinical Trials Design;Communities;Cytotoxic agent;deep learning;design;design verification;Development;Devices;Diagnosis;diagnostic development;Disseminated Malignant Neoplasm;Doctor of Philosophy;drug candidate;drug development;drug testing;Early Diagnosis;Engineering;experimental study;Funding;Funding Agency;Goals;human tissue;Image;Image Analysis;imaging approach;Imaging technology;Immunotherapeutic agent;improved;Infrastructure;inhibitor;Institution;Intellectual Property;inter-institutional;Intervention;invention;Investments;Journals;Leadership;leadership development;Machine Learning;Malignant Neoplasms;Mathematics;Medical;Medicine;meetings;member;Microscope;Modeling;molecular diagnostics;Multimodal Imaging;nanoparticle;Nature;new technology;novel;novel strategies;Optics;Peer Review;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Physics;pre-clinical;Process;Program Development;programs;Protein Engineering;Publications;Publishing;Recurrence;Research;research clinical testing;Research Personnel;Resource Sharing;response;rho GTP-Binding Proteins;Roentgen Rays;Schools;Scientist;Screening for cancer;Services;Skin Cancer;small molecule;Source;Sphingolipids;Structure;Synthesis Chemistry;Technology;technology development;technology validation;Testing;Therapeutic;Tissue Model;tissue resource;Tissues;Transgenic Mouse Facility;Translating;Translations;tumor;Validation;Vascularization

PROJECT_TITLE: Biotechnology, Imaging and Drug Development Program (BIDD)


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_NAME: UNIVERSITY OF IOWA

PHR: Every day, 50.1 million children ages 5 to 18 years attend grades K-12. About 27% of those children suffer from at least one medical condition requiring them to take medication at school. Up to 48% of school nurses reported that they made a medication administration error at school. In this study, we will be implementing a technology, similar to the one used in hospitals, to reduce medication errors at schools.

PI_NAMEs: FARAG, AMANY  (contact)

PROGRAM_OFFICER_NAME: SAMAD, FARZANA

PROJECT_TITLE: Assuring Medication Safety in K-12 Schools: Implementing and Evaluating the Electronic School Medication Administration Record (E-SMAR) System

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


PHR: SYSTEMS, PATHWAYS & TARGETS PROGRAM  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: LOWENGRUB, JOHN  (contact)

PROJECT_TERMS: Acceleration;Attention;Basic Science;behavioral study;bench to bedside;Biochemical Pathway;Biology;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;cell behavior;Cell Communication;Cells;Cellular biology;Clinical;clinical development;Clinical Investigator;Clinical Trials;Collaborations;Combined Modality Therapy;Critical Pathways;Dependence;Development;Diagnostic;Disease;Doctor of Philosophy;Drug resistance;early-career faculty;Educational workshop;Environment;Extramural Activities;Faculty;fatty acid metabolism;Fostering;Funding;Future;Goals;Grant;Heme;Heterogeneity;Immunologist;Individual;innovation;Institution;inter-institutional;Interdisciplinary Study;interest;International;Intervention;Journals;Knowledge;Laboratory Research;Lead;Leadership;Malignant Neoplasms;mathematical model;member;Metabolic;mevalonate;mid-career faculty;Modeling;multidisciplinary;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel diagnostics;novel therapeutics;Nutrient;Organ;Pathway interactions;Patients;Peer Review;Physicians;Positioning Attribute;Pre-Clinical Model;pre-clinical research;preclinical development;Process;Productivity;programs;Proliferating;Publications;recruit;Research;Research Personnel;Research Project Grants;Resources;Sampling;Schools;Scientist;Signal Transduction;single cell analysis;Site;Statistical Models;symposium;System;Systems Biology;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Tissue Sample;Tissues;Transcend;Translating;Translations;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Tissue;Validation;Work;working group

PROJECT_TITLE: Systems, Pathways and Targets Program (SPT)


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

PROJECT_TERMS: Advocate;Amendment;Attention;Cancer Therapy Evaluation Program;Clinical Trials;Clinical Trials Data Monitoring Committees;Committee Members;Complex;Data Coordinating Center;design;Development;Disease;experience;Goals;Infrastructure;Institution;International;investigator training;Knowledge;Leadership;Malignant Neoplasms;member;Mentorship;Mission;Multi-Institutional Clinical Trial;Oncology;Oncology Group;operation;Patients;Phase;Physicians;Program Development;programs;prospective;protocol development;Publications;Regulatory Affairs;Research;Research Activity;Research Personnel;Safety;Site;statistics;success;Support Groups;Translational trial;Work


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Hematology;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE: Clamping and cutting the umbilical cord at birth occurs for each of the 140 million neonates born annually. The significant public health advantages of delayed cord clamping (DCC) over early cord clamping (ECC) for healthy newborns has not been studied in neonates with critical congenital heart disease (CCHD), a population with a high frequency of adverse outcomes and, correspondingly, the potential for substantial benefit from ameliorative interventions. The studies described in the present proposal are relevant to NIH's mission to understand the processes of human growth and development, by determining, via a multicenter randomized clinical trial, whether, among neonates born with CCHD, DCC provides better outcomes post cardiac surgery or catheterization, as measured by a validated composite measure (global rank scores) and neurodevelopmental outcomes, than are observed with ECC.

PI_NAMEs: EVANS, SCOTT ;RICE, MADELINE MURGUIA (contact);SANDOVAL, GRECIO JAN

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: Academy;adherence rate;adverse outcome;Age;American;American College of Obstetricians and Gynecologists;Anatomy;Birth;Blood;Body System;Cardiac Catheterization Procedures;Cardiac Surgery procedures;Catheterization;Cesarean section;Child;Child Health;Clinical;clinically significant;Closure by clamp;cohort;Collaborations;Complement;Complex;Conduct Clinical Trials;Congenital Abnormality;congenital heart abnormality;Consent;cost;Critical Care;critical congenital heart disease;Data;Data Coordinating Center;design;Development;Diabetes Mellitus;effectiveness evaluation;Enrollment;Environment;Equipoise;Erythrocyte Transfusion;Ethnic Origin;Event;Evidence Based Medicine;Exclusion;experience;Exposure to;Family;Feasibility Studies;fetal;fetal blood;fetal diagnosis;Frequencies;Functional disorder;General Population;Gestational Age;Goals;Growth and Development function;Guidelines;Health;Health Benefit;Health Personnel;heart defect;Hematology;Hemorrhage;high risk;High-Risk Pregnancy;Hospitalization;Hospitals;Human;Hyperviscosity;improved;Infant;Infrastructure;Intensive Care;International;Intervention;Iron deficiency anemia;Joints;maternal hypertension;maternal outcome;maternal risk;Measures;Mediating;Mission;mortality;Mothers;Motor;Movement;multidisciplinary;myocardial injury;Neonatal;neonatal morbidity;neonatal resuscitation;neonate;Neurologic;Neurological outcome;Newborn Infant;Operative Surgical Procedures;Outcome;Parents;Patient-Focused Outcomes;Patients;Pediatrics;Perception;Physiological;Placenta;Polycythemia;Population;postnatal;Postpartum Hemorrhage;Pregnancy;primary outcome;Process;Public Health;Questionnaires;Race;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Records;recruit;Reporting;Research Design;Research Personnel;Risk;Safety;secondary outcome;Severities;sex;Site;Stroke;Subgroup;Surveys;Survivors;Testing;Thrombosis;Translating;Umbilical cord structure;Uncertainty;United States National Institutes of Health;Vagina;Vulnerable Populations

PROJECT_TITLE: 2/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart Disease

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(OA)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: NUTRITION

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Greater than two-thirds of mid-life and older adults are overweight or obese, and older adults with obesity face greater risk of disability, cognitive impairment, impaired mobility, and higher medical expenses. Thus, lifestyle interventions which promote moderate, sustainable weight loss among mid-life and older adults with overweight or obesity are needed. As there are currently no evidence-based water intake recommendations for weight control, we aim to address this research gap by investigating premeal water as a low-cost dietary strategy that could be incorporated into clinical practice guidelines for obesity treatment, and improve adherence to a hypocaloric diet prescription through reduced hunger, increased fullness, and improved cognitive function.

PI_NAMEs: DAVY, BRENDA M (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: Acute;Address;Adherence;Adult;adult obesity;aged;American;Appetite Regulation;Area;Attention;attentional control;Behavior;Behavioral Mechanisms;Body Weight decreased;Clinical;Clinical Practice Guideline;Cognition;Cognitive;cognitive function;comparison control;Consumption;Control Groups;cost;Dehydration;Desire for food;Diet;dietary;dietary adherence;dietary guidelines;disability risk;Disease;drinking water;efficacy study;Energy Intake;Esthesia;Evaluation;evidence base;evidence based guidelines;executive function;Face;fasting glucose;Goals;Health Benefit;healthy lifestyle;High Prevalence;Hormones;Hunger;Hydration status;Impaired cognition;improved;Instruction;Insulin;Intervention;Intervention Trial;Kidney Calculi;lifestyle intervention;Link;Maintenance;Measures;Mediating;Mediator;Medical Care Costs;men;middle age;Mobility decline;Nutritional Study;Obesity;obesity risk;obesity treatment;older adult;Osmolalities;Outcome;Overweight;overweight adults;Participant;Performance;Phase;Population;prevent;randomized controlled design;Randomized, Controlled Trials;Recommendation;Research;Satiation;Serum;Stomach;Strategic Planning;success;Time;treatment as usual;trial design;United States National Institutes of Health;Urinary tract infection;Urine;usual care arm;Water;Water consumption;Weight;Weight Gain;weight maintenance;Weight maintenance regimen;Woman;working group

PROJECT_TITLE: Water Intake and Weight Control in Older Adults

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PHR: CANCER CONTROL PROGRAM  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: MILAM, JOEL E (contact)

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;Adolescent and young adult cancer patients;Area;Asian population;Award;Behavior Control;Behavioral;biobehavior;Biostatistics Shared Resource;Biotechnology;Breast;Cancer Center Support Grant;Cancer Control;Cancer Control Research;cancer health disparity;Cancer Patient;cancer risk;Cancer Survivor;Caring;Catchment Area;Child;Childhood;Clinical Trials;Collaborations;Colorectal;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Conduct Clinical Trials;design;Detection;Diagnosis;disparity reduction;Doctor of Philosophy;drug development;Epidemiologist;Evaluation;Faculty;Faculty Recruitment;Family;follow-up;Fostering;Funding;Genetic;Genomics;Goals;Grant;Growth;Health;health disparity;Image;improved;improved outcome;Incidence;innovation;Institution;inter-institutional;interdisciplinary collaboration;Intervention;Journals;knowledge base;Latino;Leadership;Malignant Neoplasms;meetings;Melanoma;member;Minority Groups;Mission;Molecular;Morbidity - disease rate;mortality;novel;novel strategies;Online Systems;Outcome;outcome disparities;Pathway interactions;Patients;Peer Review;Pilot Projects;Play;Population;Population Study;Populations at Risk;prevent;Prevention;Program Development;programs;Prostate;psychobiologic;psychologic;Psychologist;Publications;Quality of life;Randomized, Controlled Trials;recruit;Recurrence;Research;Research Personnel;Risk Factors;Role;Schools;Scientist;Screening for cancer;social;social media;Strategic Planning;Survivors;survivorship;symptom management;System;telehealth;Testing;Training;Translating;Work

PROJECT_TITLE: Cancer Control Program (CC)


NIH_SPENDING_CATS: Aging;Urologic Diseases

ORG_CITY: MADISON

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal will determine the contribution of defects in oxidative phosphorylation to the development of fibrosis in benign prostatic hyperplasia (BPH). Specifically, this project aims to investigate the mitochondrial changes associated with aging to develop a better understanding of how oxidative phosphorylation is driving disease. This work will provide new avenues for biomarker development and treatment targets.

PI_NAMEs: ADRIAN, ALEXIS ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Address;Adrenergic alpha-Antagonists;Affect;Age;Aging;aging process;Antioxidants;Automobile Driving;Benign Prostatic Hypertrophy;Biological Assay;biomarker development;Cell Line;Cells;Collagen;Complex;Data;Defect;Development;Disease;Electrodes;Epithelium;Exhibits;FDA approved;Fibrosis;Functional disorder;Future;Genetic;Genotype;Genus Hippocampus;Goals;Health Care Costs;Human;Immunochemistry;Immunohistochemistry;improved;in vivo;Increased frequency of micturition;interest;Intervention;Knock-out;Knowledge;Liver;loss of function;Lower urinary tract;lower urinary tract symptoms;LoxP-flanked allele;MAPK8 gene;Measures;Medical;men;Metabolism;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Mitochondrial Proteins;Modeling;mortality risk;mouse model;Mus;NADH dehydrogenase (ubiquinone);novel;old mice;Oleic Acids;Outcome;Oxidative Phosphorylation;Oxygen Consumption;Pathologic;Pathology;Pathway interactions;Patient Care;Patients;Pharmaceutical Preparations;Process;Proliferating;Prostate;Prostatic;Prostatic Diseases;protein complex;Quality of life;Reactive Oxygen Species;Respiration;Risk Factors;Role;Running;Sampling;Signaling Molecule;Sirius Red F3B;Spottings;Stains;Stromal Cells;Testosterone 5-alpha-Reductase;Time;Tissues;Transforming Growth Factor beta;Up-Regulation;urinary;Work

PROJECT_TITLE: Examining the role of defective oxidative phosphorylation in the normal and diseased prostate


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Radiation Oncology

PROJECT_TERMS: Adolescent and Young Adult;African ancestry;Alaska Native;American;base;Clinical Research;Communication;Country;Credentialing;data quality;Discipline of Nursing;Disease;Enrollment;General Population;Grant;Guidelines;health disparity;Hispanic;Image;improved;innovation;Institution;Latino;Malignant Neoplasms;member;Mission;Monitor;Monitoring Clinical Trials;National Clinical Trials Network;Native Americans;Native Hawaiian;Oncology;operation;Pacific Islander;participant enrollment;Patients;Performance;Process;programs;Protocols documentation;Puerto Rico;Qualifying;quality assurance;Radiation Oncology;Radiation therapy;rare cancer;Review Committee;Science;Site;Time;Translational Research;Underrepresented Populations;Update;Washington


PHR: DEVELOPMENTAL FUNDS  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: FUNES, MELANIE  (contact)

PROJECT_TERMS: anti-cancer;anti-cancer research;Applications Grants;Area;authority;Authorship;Award;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer research center director;Catchment Area;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Communities;Comprehensive Cancer Center;Coupled;Development;Disease;Doctor of Philosophy;early phase clinical trial;Enrollment;Ensure;Equity;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Family;Feedback;Fostering;Funding;Future;Grant;innovation;Institution;Intervention;investigator-initiated trial;Investments;Leadership;Malignant Neoplasms;member;Monitor;NCI Center for Cancer Research;Patients;peer;Phase;Pilot Projects;Population Sciences;programs;Recommendation;recruit;Research;Research Activity;Research Personnel;Research Priority;Research Proposals;Resources;Role;Schools;Source;Strategic Planning;success;systems research;Talents;Translational Research;treatment trial;Underrepresented Populations;Work;Writing

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Genetics

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative Humans begin as fertilized eggs that coordinate the transformation into our familiar forms with biomolecules called proteins. Malfunctioning proteins can consequently result in birth defects, and emerging data has revealed many novel small proteins with the potential to affect human development. This study will discover the roles of these small proteins in development using an innovative system that targets and destroys protein making templates in the developmentally informative model zebrafish towards a better understanding of the players that cause human birth defects and diseases with developmental origins.

PI_NAMEs: TREICHEL, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Affect;Amino Acids;Base Sequence;Biochemical;Bioinformatics;Biology;cardiogenesis;Catalogs;Cell division;cell growth;cell motility;Cell Physiology;Cells;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Computational Biology;Congenital Abnormality;Coupled;Data;Data Set;Development;Developmental Biology;developmental disease;Diagnostic;Disease;Down-Regulation;Embryo;Embryonic Development;Epitopes;Etiology;Exclusion;Exhibits;experimental study;gastrulation;Gene Expression;gene function;Genes;Genetic;Genetic Transcription;Genome;Germ Layers;Goals;grasp;Guide RNA;heart function;Hour;Human;Human Development;human disease;human embryonic stem cell;Image;image guided;imaging approach;Immunity;Immunofluorescence Immunologic;improved;in vivo;innovation;insight;Investigation;knock-down;Link;Masks;Mass Spectrum Analysis;Maternal Messenger RNA;Messenger RNA;Microscopy;migration;Modeling;Molecular;Molecular Biology;Molecular Genetics;mutant;novel;offspring;Open Reading Frames;Pathway interactions;Pattern;Phenotype;Play;pluripotency;Population;Positioning Attribute;Process;Protein Biochemistry;protein function;Proteins;Proteomics;Publishing;Quality of life;ribosome profiling;RNA;RNA Interference;RNA Sequences;Role;Signal Transduction;skills;spatiotemporal;Specific qualifier value;System;Techniques;Testing;Therapeutic;Training;transcription factor;transcriptome sequencing;Translating;Translations;Untranslated Regions;Untranslated RNA;Variant;Zebrafish;zebrafish development;zygote

PROJECT_TITLE: Opening small packages: unraveling roles for microproteins during early vertebrate development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Cancer;Patient Safety

PHR: CLINICAL PROTOCOL AND DATA MANAGEMENT  PROJECT NARRATIVE Per PAR-20-043, a Project Narrative is not required for this component.

PI_NAMEs: HUI, CHRISTINE  (contact)

PROJECT_TERMS: Age;anti-cancer research;California;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer site;Catchment Area;central database;Cities;Clinical;Clinical Cancer Center;Clinical Data;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;cost effective;County;Data;data integrity;data management;demographics;Disease;Educational process of instructing;Ensure;Equity;ethnic diversity;Ethnic Origin;Family;Gender;Goals;Growth;Guidelines;healing;improved outcome;Individual;Industrialization;innovation;Institution;Intervention Trial;investigator-initiated trial;Leadership;life span;Malignant Neoplasms;Minority;Mission;Monitor;National Cancer Institute;National Clinical Trials Network;National Comprehensive Cancer Network;novel therapeutics;operation;Operations Research;Oranges;participant safety;patient population;Patients;Persons;Population;Positioning Attribute;Protocols documentation;Qualifying;quality assurance;Race;racial diversity;Readiness;recruit;Reporting;Research Personnel;Resources;Risk;Safety;Training;United States;Woman

PROJECT_TITLE: Clinical Protocol and Data Management/CTO/DSMB