ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: In this research program, we examine presynaptic mechanisms that regulate neurotransmitter release at retinal ribbon-style synapses. These specialized synapses, essential for vision, convey the fundamental signals we use to perceive the visual world. Knowledge of their regulation is important for developing new strategies to preserve or restore vision in patients experiencing retinal degeneration.

PI_NAMEs: HEIDELBERGER, RUTH  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Amacrine Cells;Behavior;Behavioral;Binding;Biological Assay;biophysical analysis;Biophysics;Blindness;Calcium Channel;calmodulin-dependent protein kinase II;Catalysis;Cell membrane;Cell model;Cell Physiology;Cells;cohort;Complex;complex data;Dangerousness;Data;Disease;Docking;Dyes;Electric Capacitance;Electron Microscopy;electron tomography;Electrophysiology (science);Environment;Event;Exocytosis;experience;Feedback;Fishes;Functional disorder;Funding;Goals;Human;In Vitro;inhibitor;insight;Knowledge;Light;Light Cell;Lighting;Measurement;Measures;Mediating;Membrane;Membrane Fusion;Methods;mimetics;Modeling;Modernization;Modification;Molecular;Monitor;monomer;Mus;mutant;Mutation;N-terminal;Neurons;neurotransmission;neurotransmitter release;Pathway interactions;Patients;Peptides;Phosphoproteins;Phosphorylation;preservation;presynaptic;programs;Proteins;ratiometric;Regulation;Research;Resolution;response;Rest;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal neuron;ribbon synapse;Rod;Role;Secretory Cell;sight restoration;Signal Transduction;Site;SNAP receptor;Stimulus;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;target SNARE proteins;Techniques;Testing;tool;trafficking;Transfection;transmission process;Vesicle;Vision;Vision Disorders;Visual;visual information

PROJECT_TITLE: Mechanisms of Neurotransmission in Vertebrate Retina

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: NR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Improving blood pressure control in African Americans is critical to improving health equity for African Americans. This study tests a novel church-based intervention to improve blood pressure control in African Americans by improving healthy diet and medication adherence.

PI_NAMEs: LYNCH, ELIZABETH B (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: active control;active control group;Address;Adherence;Adult;African American population;arm;Attention;behavior change;Behavior Therapy;Behavioral;Belief;Bible;Black church;Blood Pressure;blood pressure control;blood pressure intervention;blood pressure medication;blood pressure reduction;Cardiovascular Diseases;Cardiovascular system;Caring;Church;Clinical;clinically significant;Communities;Community Health Aides;community partners;Comparison arm;comparison group;Coronary heart disease;cost;DASH diet;design;Diastolic blood pressure;Diet;dietary adherence;Dietary Intervention;distrust;Education;Educational Intervention;efficacy testing;Event;follow-up;Food;Goals;good diet;health equity;Healthcare Systems;Healthy Eating;healthy lifestyle;Heart failure;Hypertension;improved;Individual;Intake;Intervention;intervention effect;intervention participants;intrinsic motivation;Knowledge;Life Expectancy;Life Style;lifestyle intervention;Link;Low income;medication compliance;meetings;member;Monitor;Morbidity - disease rate;mortality;Motivation;motivational enhancement therapy;novel;nutrition education;Participant;Pharmaceutical Preparations;Pilot Projects;Population;post intervention;preference;preservation;Problem Solving;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Resources;Risk;Risk Reduction;Self Efficacy;Social support;Sodium;Spirituality;Stroke;Testing;Training;treatment arm;trial design;Trust;Vegetables

PROJECT_TITLE: Alive Blood Pressure Project: A church-based intervention to improve blood pressure

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Maternal Health;Mental Health;Microbiome;Neurosciences;Pediatric;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: PSYCHIATRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: Stress during pregnancy is common and alters neurodevelopment in a way that increases the risk of development of psychiatric disorders in the offspring. How stress is transmitted from changes in maternal microbes to the developing brain in utero is an open question. This interdisciplinary study will focus on early inflammatory abnormalities in the developing brain which result in long term behavioral changes.

PI_NAMEs: GUR, TAMAR  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Adult;Adult Children;Anxiety;Automobile Driving;Behavior;Behavioral;beta-Chemokines;Blood Vessels;Brain;Breeding;CCL2 gene;Cell Line;Cell Survival;Cells;Central Nervous System;chemokine;cytokine;Cytokine Signaling;Data;Development;Exhibits;experimental study;Exposure to;fetal;Fetal Development;Flow Cytometry;Foundations;Future;Gene Modified;Germ-Free;gliogenesis;Goals;Immune;Immunohistochemistry;in utero;Inflammation;Inflammatory;Interdisciplinary Study;Intervention;intrauterine environment;ITGAM gene;Label;Ligands;Limbic System;Link;Macrophage;maternal microbiome;mature animal;Meninges;Mental Depression;Mental disorders;Microbe;microbial;microbial community;microbiome;microbiota;Microglia;Modeling;monocyte;Mothers;mouse model;Mus;Myelogenous;Myeloid Cells;neural circuit;neurobehavioral;neurodevelopment;neuroinflammation;novel;offspring;Outcome;Pathogenicity;Pathology;Pathway interactions;Play;Population;Prefrontal Cortex;Pregnancy;prenatal;prenatal stress;prevent;Production;Resistance;response;Risk;Role;single-cell RNA sequencing;Social Behavior;social deficits;Sorting;Source;Stress;Structure of choroid plexus;Testing;Time;transmission process;Work

PROJECT_TITLE: Prenatal neuroinflammation: maternal microbiome contributions and behavioral consequences

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Orphan Drug;Ovarian Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE  The overall goal of the current proposal is to develop and validate a combined mutation and methylation assay as a clinical predictor of PARP inhibitor response. We will develop and refine a quantitative methylation assay, then test whether combining methylation and mutation analyses can predict PARP inhibitor sensitivity in patients with BRCA wildtype cancers using clinical samples from 4 large randomized controlled trials in ovarian and breast cancer.

PI_NAMEs: SWISHER, ELIZABETH MARY (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Alleles;Antineoplastic Agents;Biological Assay;BRCA mutations;BRCA1 gene;BRCA2 gene;cancer cell;cancer therapy;cancer type;cell killing;Cells;chemotherapy;Clinical;clinical predictors;Collaborations;companion diagnostics;cost;cost effective;Decision Making;Development;diagnostic biomarker;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Down-Regulation;Drug usage;Formalin;G2 Phase;Gene Expression Regulation;gene repair;Genes;Goals;Gynecologic Oncology Group;homologous recombination;homologous recombination deficiency;improved;insight;Laboratories;Maintenance;Maintenance Therapy;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Medicine;Methylation;methylation testing;Mutation;Mutation Analysis;mutation assay;neoplastic;Nonhomologous DNA End Joining;Oncology;Open Reading Frames;Ovarian Carcinoma;Paraffin Embedding;Patient Selection;Patients;Peritoneal;personalized therapeutic;Phase;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;predicting response;predictive marker;promoter;RAD51C gene;Randomized, Controlled Trials;recombinational repair;Recurrence;repaired;Resistance;response;S phase;Sampling;Solid;Somatic Mutation;Specimen;Testing;Therapeutic;therapeutic target;Toxic effect;triple-negative invasive breast carcinoma;Tumor Bank;Tumor Tissue;Work

PROJECT_TITLE: Combined Methylation and Mutation to Predict Response to PARP Inhibitors

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Emphysema;Lung;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Many proteins are modified after they are produced in cells. One form of protein modification called citrullination is important for proper function of cells and organs. Better understanding of how citrullination is regulated and how it affects the function of human cells and organs will uncover novel strategies of improving human health.

PI_NAMEs: HO, I-CHENG  (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Adult;Affect;Age;age related;Aneurysm;Arteries;Biochemical;Biological Process;biophysical techniques;Cell Physiology;cell type;Cells;Charge;Chronic Obstructive Pulmonary Disease;Cigarette smoke-induced emphysema;cigarette smoking;Clinical;Data;Development;effective therapy;Elastic Fiber;Elasticity;Elastin;extracellular;FBLN5 gene;Fibroblasts;Functional Regeneration;Genetic;Genetically Engineered Mouse;Goals;Health;Human;human disease;idiopathic pulmonary fibrosis;Impairment;improved;In Vitro;Knowledge;Life;Link;Lung;Lung Compliance;Lung Diseases;Mediating;Modeling;Modification;Molecular;Monoclonal Antibodies;monomer;Morphology;Mus;novel;novel strategies;novel therapeutic intervention;Organ;overexpression;Pathologic;perinatal period;pharmacologic;Physiological;Physiology;Post-Translational Protein Processing;Predisposition;protein expression;protein function;Protein-arginine deiminase;Proteins;Proteomics;Pulmonary Emphysema;pulmonary function;Reagent;Rheumatoid Arthritis;Role;Site;Skin;Stimulus;Substrate Specificity;Time;Tissues;Untranslated RNA

PROJECT_TITLE: Regulatory roles of peptidylarginine deimination in elastogenisis

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Relevance to public health Currently available oral cholera vaccines have a number of shortcomings. Developing improved vaccines or vaccination strategies is hampered by the reality that we do not currently understand the mechanism of immune protection against cholera. We have strong preliminary evidence that immune responses targeting O-specific polysaccharide (OSP) affect Vibrio cholerae, and we here propose an investigative approach to define and evaluate these effects.

PI_NAMEs: RYAN, EDWARD T. (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: 5 year old;Address;Affect;Age;Antibodies;Antibody Response;antigen binding;Antigens;Bangladesh;Bangladeshi;Binding Sites;Biopsy;blood group;Blood typing procedure;Cessation of life;Child;Cholera;Cholera Vaccine;Clinical;Clinical Research;cost;Country;Data;Dehydration;dimer;Disease;Ecology;Endoscopy;Evaluation;experience;Gender;Genetic;Goals;holotoxins;Homing;Household;Human;human monoclonal antibodies;human subject;Immune;Immune response;immunogenic;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologics;improved;Ingestion;Institutional Review Boards;International;Intestines;long term memory;Lymphocyte;Mediating;Mediator;Memory B-Lymphocyte;Methods;Modeling;Monoclonal Antibodies;Motility;Mucins;Mucosal Immune Responses;Mucous Membrane;nano;Nature;novel;O Antigens;Oral;pathogen;Patients;Peer Review;Penetration;Plasmablast;Population;Positioning Attribute;programs;Protocols documentation;Public Health;Publications;Reagent;Resources;response;Sampling;sound;Structure;success;T-Lymphocyte;Testing;Tissues;translational medicine;Translational Research;Vaccinated;Vaccination;vaccination strategy;vaccine strategy;Vaccinee;Vertebral column;Vibrio cholerae;Vibrio cholerae infection;Vibrio cholerae O1;Work

PROJECT_TITLE: O-Specific Polysaccharide Responses and Cholera

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research seeks to address the substantial burden of unmet mental health need for Black and Latinx children who have been sexually abused. We will develop and pilot test a novel engagement intervention for Black and Latinx caregivers, whose children have the highest rates of unmet mental health need after sexual abuse. This intervention, which aims to increase children’s receipt of mental health services after sexual abuse, will provide an urgently needed strategy to improve mental health care delivery and promote positive outcomes for children at significant risk of lifelong psychopathology from sexual abuse.

PI_NAMEs: FONG, HIU-FAI  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: acceptability and feasibility;Address;adverse outcome;Affect;Area;Behavior Therapy;Behavioral;biomedical referral center;Black race;Boston;care seeking;career development;Caregivers;Case Manager;catalyst;Child;Child Abuse;Child health care;Child Sexual Abuse;Child Welfare;Childhood;Clinic;clinical encounter;Clinical Trials;Communities;community advisory board;community based participatory research;design;Development;Development Plans;Disparity;Educational Intervention;effectiveness evaluation;Ensure;Ethical Issues;ethnic disparity;ethnic minority;Evidence based intervention;Expectancy;experience;Family;Feedback;Feeling;Female;Focus Groups;Future;Goals;Guilt;healing;health care delivery;health care disparity;health disparity;Health Promotion;improved;improved outcome;Individual;Inequity;information gathering;Institution;Intervention;intervention refinement;Interview;Latinx;Legal Guardians;life span;male;medical schools;medical specialties;Mental Depression;Mental Health;Mental Health Services;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;minority engagement;Minority Groups;Minority Health Research;minority patient;Modeling;National Institute on Minority Health and Health Disparities;novel;Outcome;Parents;Patient Education;Patients;Pediatric Hospitals;pediatrician;Perception;Pilot Projects;pilot test;Population;Population Heterogeneity;Population Intervention;Positioning Attribute;Post-Traumatic Stress Disorders;preference;prevent;preventive intervention;Process;Psychopathology;Public Health Schools;Quality of Care;racial disparity;racial minority;racism;Randomized;Randomized, Controlled Trials;Research;research and development;Research Personnel;Resources;Risk;Sampling;satisfaction;Self Efficacy;Self Management;Services;Sexual abuse;Shame;shared decision making;social culture;social norm;social stigma;Social Workers;Spanish;Spanish/English;Substance abuse problem;Suicide attempt;Testing;therapy development;Training;Trauma;treatment as usual;Voice;Work

PROJECT_TITLE: Developing an engagement intervention for Black and Latinx caregivers to improve children’s receipt of mental health services after sexual abuse


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative Emerging ‘superbugs’, which are resistant to multiple antimicrobials, pose a daunting threat to current treatment protocols. Acinetobacter baumannii can develop multidrug resistance without acquisition of new resistance genes. Basic characterization of the underlying intrinsic resistance mechanisms will guide new antimicrobial development and improve current therapeutic treatment protocols.

PI_NAMEs: BOLL, JOSEPH MICHAEL (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Abbreviations;Acinetobacter baumannii;Affect;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Bacteremia;Bacterial Physiology;Biogenesis;biological adaptation to stress;carbapenem resistance;Carbapenem-resistant Acinetobacter;Carbapenems;Carboxypeptidase;cell envelope;Cell model;Cell Shape;Cell Wall;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Colistin;colistin resistance;combat;combinatorial;Compensation;crosslink;Cytoprotection;Defect;design;Development;Enzyme Activation;Enzymes;Escherichia coli;extensive drug resistance;Fortification;Fostering;Glucosyltransferase;glycosyltransferase;Goals;Gram-Negative Bacteria;Growth;Hospitals;Human;human disease;Immunoprecipitation;improved;Infection;Intrinsic factor;Knowledge;Laboratories;Life;Link;lipooligosaccharide;Lipoproteins;Lytic;Measures;mechanical force;mechanical load;Mechanics;Membrane;Mission;Modeling;Modification;molecular modeling;Molecular Weight;Multi-Drug Resistance;Nosocomial Infections;Osmotic Shocks;pathogen;Penicillin-Binding Proteins;Peptidoglycan;Peptidyltransferase;Pharmaceutical Preparations;Phenotype;Physiology;Polymyxins;Property;Public Health;Refractory;Regimen;Regulation;Reporting;Resistance;resistance gene;resistance mechanism;response;Role;Stress;Structure;Superbug;System;Testing;Therapeutic;Treatment Failure;Treatment Protocols;treatment strategy;United States National Institutes of Health;Urinary tract;Vesicle;Work;World Health Organization;Wound Infection

PROJECT_TITLE: Mechanistic basis of how LD-transpeptidases protect against outer membranedefects

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE In Armenia (AM), NCDs account for 93% of deaths, cancer death rates are the 2nd highest globally, and CVD rates are the 35th highest; thus, addressing NCD risk factors (e.g., tobacco/alcohol use, diet) is crucial, with 52% of men smoking (11th highest rate globally) and 48% of adults overweight/obese in AM. Social determinants (SDs) impact NCD risk factors, outcomes, and disparities, and are key drivers of NCDs in AM; thus, we propose the Armenia-US Collaboration to Address Chronic Disease via Education in Social Determinants Science (ACCESS) program. ACCESS is a strategic partnership between George Washington University and American University of Armenia, alongside AM’s Ministry of Health and its entities, and aims to reduce the NCD burden in AM by enhancing research capacity related to NCD prevention and control, focusing on SDs of NCD risk factors; we will enhance (1) formal training and institutional infrastructure, (2) mentored research opportunities, and (3) dissemination and translational skills to optimize impact in AM and globally.

PI_NAMEs: BERG, CARLA J (contact);PAICHADZE, NINO ;PETROSYAN, VARDUHI

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Alcohol consumption;Alcoholism;American;Armenia;Awareness;burden of illness;Cause of Death;Cessation of life;Chronic Disease;Clinical;Collaborations;Communities;Country;COVID-19 pandemic;disability;Disease;Disease Outcome;disorder control;disorder prevention;disorder risk;Disparity;Doctor's Degree;Education;Face;Future;Goals;Health;health disparity;Health Priorities;Healthcare;Inequality;Infrastructure;Institution;knowledge translation;low and middle-income countries;male;Mentors;Obesity;Overweight;Play;Policies;premature;Prevalence;Program Sustainability;programs;Public Health;Research;research data dissemination;Research Infrastructure;Research Personnel;Research Training;response;Risk Factors;Role;Science;skills;Smoking;social determinants;Social Environment;Students;Tobacco;Training;Training Programs;Unhealthy Diet;United States National Institutes of Health;Universities;Washington


NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Prenatal exposure to unsafe levels of heavy metals such as cadmium and arsenic through food and drinking water is an unavoidable risk factor concerning communities with disproportionately high burden of airway disorders, healthcare disparity and environmental injustice. There are no effective prevention and intervention strategies against prenatal exposures due to the lack of understanding in abnormal vs normal airway development modulated by environmental stressors. This application will provide critical mechanistic information on how prenatal exposures at human-relevant levels quantitatively impact airway development and growth in mouse models.

PI_NAMEs: HU, XIN  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;Adult;Adverse effects;Affect;Anabolism;Arsenic;Atlases;attenuation;Biology;Cadmium;cancer risk;Carbamyl Phosphate;Cell Communication;Cell Differentiation process;cell growth;Cell membrane;Cell Physiology;Cell Proliferation;cell type;Cells;Cellular Structures;Child;Chondroitin Sulfate Proteoglycan;Chondroitin Sulfates;Communities;Complex;Cytidine Diphosphate Choline;Cytoplasm;Cytosine;Defect;Development;Disease;disease prognosis;disorder risk;DNA;DNA biosynthesis;drinking water;Embryo;environmental agent;Environmental Exposure;Environmental Impact;Environmental Risk Factor;environmental stressor;Enzymes;Epigenetic Process;Epithelium;Equilibrium;Experimental Models;Exposure to;fetal;Fetal Alcohol Exposure;Fetal Development;Food;Foundations;Future;Gene Expression;Genetic Transcription;Glycolysis;Growth;Growth and Development function;Growth Factor;Health;health care disparity;health management;Heavy Metals;Heparitin Sulfate;Human;Impairment;innovation;Intervention;Lecithin;Life;Ligase;Link;lipid metabolism;Lipids;Long-Term Effects;Lung;lung development;Lung Diseases;lung health;Malignant neoplasm of lung;Measurable;Measures;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolomics;Mitochondria;Mitochondrial Proteins;Morphogenesis;mouse model;Mus;Newborn Infant;Nicotine;nicotine exposure;Normal Cell;novel;Nucleic Acid Precursors;nucleoside triphosphate;orotate;Output;oxidation;Pathologic;Pathway interactions;Phenotype;Phospholipid Metabolism;Phospholipids;Pilot Projects;Placenta;Plasma;Play;Population;Post-Translational Protein Processing;postnatal;Predisposition;Pregnancy;Pregnant Women;prenatal exposure;Prevention;Prevention strategy;Production;Proliferating;Protein Glycosylation;Proteoglycan;Proteome;Public Health;pulmonary function;Pyrimidine;pyrimidine metabolism;Pyrimidine Nucleosides;Pyrimidines;Research;Respiratory Disease;Respiratory physiology;Risk;Risk Factors;RNA;RNA chemical synthesis;Role;Signal Transduction;single-cell RNA sequencing;small molecule;stem;Structure;Testing;Thymine;tool;Transcription Alteration;transcriptome;transcriptomics;Translational Research;Uracil;Uridine Diphosphate Sugars;Variant

PROJECT_TITLE: Cadmium and Arsenic Effects on Pyrimidine Biosynthesis in Early Airway Development

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative The research in this proposal will generate novel methodologies to improve disease risk prediction for the underrepresented minority populations by integrating trans-ethnic, disparate sources of information on the genetic markers and other factors such as clinical factors, health conditions, and socio-demographic indicators. In addition, it will provide enhanced, user-friendly disease risk prediction tools for multi-ethnic populations, as well as general data integration methodologies that can be widely implemented to accelerate future research in disease risk prediction and prevention.

PI_NAMEs: JIN, JIN  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Acceleration;Advisory Committees;Alzheimer's Disease;Area;Award;Bayesian Method;Bayesian Modeling;biobank;Biological;Biological Markers;career;career development;cell type;Clinical;Collaborations;Communication;Communities;Complex;Computing Methodologies;Coronary Arteriosclerosis;COVID-19 mortality;Data;data fusion;data integration;Data Set;Data Sources;Disease;disease model;disorder risk;Disparate;Educational process of instructing;Educational workshop;Ensure;Environment;Epidemiology;epidemiology study;ethnic disparity;ethnic diversity;Ethnic Origin;Ethnic Population;European;flexibility;functional genomics;Gene Frequency;Genetic;Genetic Markers;Genetic Risk;genetic variant;genome wide association study;Genomics;Goals;Grant;Health;health inequalities;Healthcare;Heart Diseases;Heterogeneity;high dimensionality;human disease;improved;Individual;interdisciplinary collaboration;Interdisciplinary Study;Interview;Knowledge;lifestyle factors;Linkage Disequilibrium;Literature;machine learning framework;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;men;Mentors;Methodology;Methods;Minority Groups;model building;Modeling;Modernization;mortality;mortality risk;multi-ethnic;multidisciplinary;non-genetic;novel;Odds Ratio;Parameter Estimation;Pathway interactions;Phase;Plasma Proteins;polygenic risk score;Population;Population Heterogeneity;precision medicine;Predictive Factor;predictive tools;Prevention;Prevention Research;Privatization;programs;Proteins;Public Health;Publishing;racial disparity;Research;Research Personnel;Research Support;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Sample Size;Services;Single Nucleotide Polymorphism;skills;sociodemographics;Software Tools;Source;statistics;Stroke;Structure;success;symposium;Tissues;tool;Training;trait;Underrepresented Minority;Universities;Urine;user friendly software;user-friendly;Woman;Writing

PROJECT_TITLE: Multi-ethnic risk prediction for complex human diseases integrating multi-source genetic and non-genetic information

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Single-cell sequencing of clinical specimens uniquely enables studies of tissue heterogeneity, a significant barrier to precision medicine. However, the use of single-cell assays for clinical decision making is limited. This project bridges that gap and develops algorithms to integrate heterogeneous single-cell datasets to support the selection of combination therapies.

PI_NAMEs: DIAZ, AARON ANTONIO (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Adult Glioma;Algorithms;Anatomy;Antigen Targeting;Basic Science;Biological Models;Biopsy;Brain Neoplasms;California;cancer recurrence;Cell Line;Cells;Cellular Assay;chemotherapy;Childhood Brain Neoplasm;Chromatin;Clinic;Clinical;clinical care;clinical decision support;clinical decision-making;clinical sequencing;clinically actionable;clinically relevant;Code;cohort;combinatorial;Combined Modality Therapy;Complex;dashboard;Data;data dashboard;data integration;Data Set;Databases;Diagnosis;Disease;Disease Progression;DNA sequencing;Evolution;exome sequencing;Gene Expression;Genetic;Genomic approach;genomic predictors;genomic profiles;genotoxicity;Genotype;Glioblastoma;Glioma;Goals;Heterogeneity;Histology;human DNA sequencing;Image;immune cell infiltrate;improved;In Situ;in vivo;Informatics;Institution;Invaded;Ionizing radiation;Learning;Leukocytes;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Maps;Measurement;Measures;Medulloblastoma;Methodology;Methods;Modeling;Modernization;Monitor;Morphology;multiple omics;Mutation;neoantigens;Non-Malignant;novel;Organoids;Outcome;outcome prediction;Patients;Pharmaceutical Preparations;Phenotype;Phylogenetic Analysis;Phylogeny;precision medicine;precision oncology;Precision therapeutics;Prediction of Response to Therapy;Predictive Cancer Model;predictive modeling;Primary Neoplasm;Process;prognostic signature;Prospective cohort;Recommendation;Recurrence;Reporting;research clinical testing;Resistance;response;risk stratification;RNA;San Francisco;Selection for Treatments;simulation;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;Site;Source;spatial integration;Specimen;statistics;System;T cell therapy;targeted treatment;Tissues;Training;training data;transcriptome sequencing;transcriptomics;Transposase;tumor;tumor heterogeneity;Universities;Validation;Visualization;Work;XCL1 gene

PROJECT_TITLE: An informatics framework for single-cell multi-omics from clinical specimens

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE the recreational adjunct to psychotherapy for Post-Traumatic Stress Disorder, but it also has a potential for abuse, and may have adverse cardiovascular and neuropsychiatric effects. MDMA has unique effects on social behavior in humans, which we have modeled in mice. In this proposal we use MDMA as a probe to understand neural mechanisms of potentially therapeutic social behaviors, which may lead to safer treatment for a range of psychiatric conditions.

PI_NAMEs: HEIFETS, BORIS DOV (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: abuse liability;Acute;Affective;Affinity;Algorithms;American;Anatomy;Area;Atlases;autism spectrum disorder;Axon;Behavior;behavior test;Behavioral;Biological Assay;Biological Markers;Brain;brain based;Brain Mapping;Brain region;Cardiovascular system;Cell Nucleus;Cells;Chronic;Claustral structure;Clinical;conditioned place preference;craving;Data;Detection;Development;Dopamine;Dorsal;drug craving;drug reward;Drug usage;ecstasy;Elements;Empathy;experience;Feeling;Fenfluramine;FOS gene;Fostering;Genetic;Goals;Human;human imaging;Image;imaging study;Immediate-Early Genes;Label;Learning;Light;Link;Maps;Mediating;Mental disorders;Methamphetamine;Methods;Microscopy;Modeling;Molecular;mouse model;Mus;neural;neural circuit;neuroimaging;neuromechanism;Neuromodulator;Neurons;neurophysiology;neuropsychiatry;novel;novel therapeutics;Nucleus Accumbens;Operant Conditioning;optogenetics;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase III Clinical Trials;Phenotype;Post-Traumatic Stress Disorders;pre-clinical;preference;Process;Property;Psychotherapy;Publishing;receptor;Recreation;Reproducibility;Research;Research Personnel;Resolution;Rewards;Risk;Role;Scientist;Selective Serotonin Reuptake Inhibitor;Serotonin;social;social anxiety;Social Behavior;social deficits;Social Environment;Structure;success;Synapses;Techniques;Testing;Therapeutic;Tissues;Toxic effect;Trust;Viral

PROJECT_TITLE: Mapping Neural Circuit Activity Mediating MDMA's Prosocial Effect

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: SIRT3 Narrative We discovered that the mitochondrial sirtuin SIRT3 is required to maintain the growth and survival of DLBCLs and is especially highly expressed in those lymphomas with the worst clinical outcome. Herein, we will develop the basis for translating SIRT3 targeted therapy to the clinic for these chemotherapy resistant patients who have few viable therapeutic options. We will develop SIRT3 lead compounds for clinical translation and define potential resistance mechanism and the means to overcome them.

PI_NAMEs: MELNICK, ARI M. (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acetyl Coenzyme A;Amino Acids;Apoptosis;Autophagocytosis;B-Lymphocytes;Basic Science;Biochemical;Biochemical Pathway;Biological;Biological Assay;Biological Models;Biology;Bypass;cell killing;Cells;Chemoresistance;chemotherapy;Citric Acid Cycle;Clinic;Clinical;clinical translation;combinatorial;Complex;Data;Deacetylase;Deacetylation;effective therapy;Enzymes;Generations;Genetic;Genetic Heterogeneity;Glutamine;Growth;Impairment;improved;In Vitro;in vivo;Inferior;inhibitor;Intervention;knock-down;Knockout Mice;large cell Diffuse non-Hodgkin's lymphoma;Lead;Link;loss of function;Lymphoma;Lymphoma cell;Lymphomagenesis;Lysine;Mediator;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;molecular targeted therapies;Mus;Mutation;novel;Nutrient;Outcome;overexpression;Oxidoreductase;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;precision medicine;Precision therapeutics;prevent;Production;programs;Proliferating;rational design;Recurrence;Refractory;Regimen;Reporting;Research;Resistance;resistance mechanism;Role;Sirtuins;small molecule;small molecule inhibitor;Somatic Mutation;Stress;Structure of germinal center of lymph node;targeted agent;targeted treatment;Text;Therapeutic;therapeutic target;Translating;Treatment Efficacy;tumor;Tumor Suppressor Proteins;Work

PROJECT_TITLE: Therapeutic targeting of SIRT3 for aggressive and refractory lymphomas

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: Newark

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative This project will study how virtual reality augmented bicycling using visual feedback and competition will increase exercise intensity, motivation, and enjoyment for persons with Parkinson's Disease. The short-term goal of the study is to select exercise strategies that yield the highest intensity and promote greatest motivation. The long- term goal is to design optimal exercise training programs that are accessible and promote mobility and fitness for persons with Parkinson's Disease so they may maintain a high-level of activity, participation and well-being.

PI_NAMEs: PALMIERI, JOHN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Animal Model;Applied Research;Area;Attention;Autonomic Dysfunction;Behavior;Bicycling;Bradykinesia;Cardiovascular system;Central Nervous System;Clinical;Clinical assessments;Cognitive deficits;Communities;comorbidity;Coupled;Data;design;Disease;Dopamine;Dopamine Receptor;Educational process of instructing;efficacy testing;Elderly;Elements;Emotional;Engineering;Environment;Equilibrium;Equipment;Equipment and supply inventories;Exercise;exercise intensity;exercise program;exercise regimen;exercise training;Exertion;experience;Fatigue;Feedback;fitness;Gait;Gait abnormality;Goals;graduate student;head mounted display;Health;Heart Rate;Human Resources;improved;improved mobility;insight;interest;intrinsic motivation;Knowledge;Laboratories;Measures;Mental Depression;Mentors;Mentorship;Mobility decline;Modeling;Motivation;Motor;motor control;motor rehabilitation;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Nerve Degeneration;Neurologic;neuromuscular;neuromusculoskeletal;Neuronal Plasticity;non-motor symptom;parent grant;Parkinson Disease;Participant;patient population;Patients;Perception;Personal Satisfaction;Persons;Pharmacotherapy;Population;post stroke;Posture;posture instability;Program Accessibility;programs;Quality of life;Recommendation;Rehabilitation therapy;Reporting;Research;Risk;Role;Scientist;Services;Severity of illness;side effect;skills;Sleep disturbances;Speed;Stimulus;Strenuous Exercise;Students;System;Therapeutic Effect;Time;tool;Training;virtual;Virtual and Augmented reality;virtual environment;virtual reality;Visual attention;visual feedback;Work

PROJECT_TITLE: Enhancing Exercise Intensity, Motivation and Enjoyment for Persons with PD: Comparing Visual Feedback and Competition in A Virtual Cycling Environment (VCYCLE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PHR: PROJECT NARRATIVE Subject motion is the fundamental impediment to reaping the full benefits of fetal-brain magnetic resonance imaging, as it frequently produces images with dramatic artifacts. The goal of this project is to exploit innovations in deep learning and integrate them into the acquisition pipeline to overcome the challenges posed by motion in fetal neuroimaging studies. This will be achieved by using fast, automated scan prescription of standard anatomical planes and by adaptively updating the acquisition as motion happens in the scanner, based on sub-second navigator scans interleaved with the imaging sequence.

PI_NAMEs: HOFFMANN, MALTE  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: 3-Dimensional;Address;Algorithmic Analysis;Amniotic Fluid;Anatomy;Archives;Automation;Brain;Brain imaging;brain magnetic resonance imaging;Calibration;Childhood;Clinical;Clinical assessments;Clinical Research;convolutional neural network;cost;Data Set;deep learning;Development;Diagnostic;echo detection;Echo-Planar Imaging;Exclusion;experience;fetal;Fetal Development;Fetus;Geometry;Goals;Head;Image;improved;Individual;innovation;interest;Label;Lead;Learning;Magnetic Resonance Imaging;Manuals;Masks;Measures;Morphologic artifacts;Motion;neuroimaging;Neurosciences;novel;Patients;Phase;Physics;Physiologic pulse;Population;Positioning Attribute;prospective;Radial;radiologist;reconstruction;Recording of previous events;repaired;Research;research study;Residual state;Resolution;response;Sampling;Scanning;Scientist;Signal Transduction;skills;Slice;Speed;success;Technology;Thick;Three-Dimensional Imaging;Time;Tissues;tool;Training;Training Programs;Translating;two-dimensional;ultrasound;Update;Work

PROJECT_TITLE: Fast motion-robust fetal neuroimaging with MRI


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_NAME: DANA-FARBER CANCER INST

PHR: TNBC is a recalcitrant malignancy with limited therapeutic options. Our research supported by this grant has demonstrated that the MUC1-C oncoprotein drives TNBC stemness, drug resistance and immune evasion. Based on these findings, our proposed research focuses on the development of new agents that target the MUC1-C extracellular and cytoplasmic domains for advancing TNBC treatment.

PI_NAMEs: KUFE, DONALD W. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Address;Alleles;Allogenic;Amino Acids;anti-PD-L1 therapy;Antibodies;Antibody-drug conjugates;Antineoplastic Agents;brca gene;Breast Cancer Cell;Breast Cancer Patient;breast cancer progression;Breast Cancer Treatment;C-terminal;cancer stem cell;cancer therapy;carcinogenesis;Cells;chemotherapy;chimeric antigen receptor T cells;chromatin remodeling;Chronic;Clinic;Clinical;clinical development;Combination Drug Therapy;Cytoplasmic Tail;Development;Dimerization;Disease;DNA Damage;Drug resistance;Effectiveness;Epigenetic Process;Evaluation;Exhibits;experience;extracellular;Extracellular Domain;Funding;Generations;genotoxicity;Grant;Human;Immune checkpoint inhibitor;Immune Evasion;Immunotherapeutic agent;Immunotherapy;improved;Inflammation;inhibitor;Malignant Neoplasms;Membrane;Molecular;Mucin 1 protein;Mucins;N-terminal;New Agents;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenic;Oncoproteins;Outcome;Patients;Penetration;Peptides;Phase;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Principal Investigator;programs;Progressive Disease;Refractory;Research;research clinical testing;Research Support;Resistance;Resistance development;resistance mechanism;small molecule;Specimen;stemness;success;targeted agent;Therapeutic;Transmembrane Domain;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Work;Writing

PROJECT_TITLE: Targeting the MUC1-C Oncoprotein in Triple-Negative Breast Cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Data Science;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: MM is a common disease that can cause substantial morbidity and mortality in patients. The success of the predictive models developed in this project will not only provide a quantitative and reliable decision support for early prediction of treatment response and patient outcome but also constitute a strong foundation to meet our long-term goal of developing a clinically-translatable framework to facilitate clinical decision making in early diagnosis and tumor burden assessment, staging, assessing treatment response, optimizing therapeutic regimens, monitoring MM progression/regression and detecting recurrence, as well as assisting in new therapeutic agent and drug development. The advancement in these areas is expected to deliver the promise of precision medicine for MM by improving patient outcomes and reducing the cost of healthcare.

PI_NAMEs: DONG, QIAN ;ZHOU, CHUAN  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Affect;Aftercare;Anatomy;Architecture;Area;Artificial Intelligence;Big Data;Big Data Methods;Bone Marrow;Bone marrow biopsy;Bone Marrow Involvement;Clinic;Clinical;Clinical Data;clinical decision-making;Clinical Management;clinical translation;Clinical Trials;Compensation;Data;Decision Support Systems;Dependence;design;Detection;Development;Disease;Drops;drug development;Early Diagnosis;Effectiveness;Evolution;flexibility;follow-up;Foundations;Functional disorder;Genetic Complementation Test;Goals;Guidelines;Health Care Costs;Hematologic Neoplasms;Heterogeneity;Image;imaging modality;improved;in vivo;Individual;individualized medicine;Infiltration;insight;Institution;International;Ionizing radiation;Laboratories;large datasets;Learning;Lesion;Life Expectancy;machine learning method;Magnetic Resonance Imaging;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;MRI Scans;multimodality;Multiple Myeloma;Non-Hodgkin's Lymphoma;novel therapeutics;outcome prediction;Pathologic;patient variability;Patient-Focused Outcomes;Patients;Pattern;Performance;Pharmaceutical Preparations;Physicians;Physiologic pulse;Play;precision medicine;Prediction of Response to Therapy;predictive modeling;Predictive Value;Prognosis;prognostic model;prognostic value;Psychological reinforcement;radiomics;Recommendation;Recurrence;recurrent neural network;Regimen;Risk;risk prediction;Role;Serial Magnetic Resonance Imaging;Severities;Source;Staging;success;Surrogate Endpoint;survival prediction;System;Techniques;Testing;Therapeutic;Therapeutic Agents;Time;Training;Treatment outcome;treatment response;tumor;Tumor Burden;tumor microenvironment;Validation;working group

PROJECT_TITLE: A framework for integrating MR imaging and clinical tests for prediction of outcomes in multiple myeloma treatment

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Comparative Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Projective Narrative Dehydration due to diarrheal diseases remains a leading cause of death in both children and adults worldwide, yet health workers lack validated tools that can help them assess and manage dehydration in patients with diarrhea. This proposed research will validate a recently developed mobile phone application that uses artificial intelligence to help health workers of all types to estimate the severity of dehydration in patients with diarrhea and provide the correct type and amount of rehydration fluids. This novel clinical decision support tool has the potential to improve medical care for the hundreds of millions of patients each year presenting to healthcare facilities around the world with diarrhea.

PI_NAMEs: LEVINE, ADAM CARL (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: 5 year old;Acute Diarrhea;Adult;Adverse event;Age;Algorithms;Artificial Intelligence;artificial intelligence model;Award;Bangladesh;Benign;Caring;Cause of Death;Cellular Phone;Cessation of life;Child;Clinical;clinical decision support;clinical diagnostics;cost effectiveness;Country;Dehydration;Diagnosis;Diarrhea;diarrheal disease;disability;Disease;Effectiveness of Interventions;Ensure;Epidemic;experience;Future;Generations;Guidelines;Health;Health care facility;Health Personnel;Healthcare;Hybrids;Hydration status;implementation science;improved;international center;Intervention Trial;IV Fluid;Lead;life span;Liquid substance;Managed Care;Medical;mHealth;Mobile Health Application;Modeling;Morbidity - disease rate;mortality;novel;Nurses;Observational Study;Oral;Patients;Physicians;Population;prospective;Prospective Studies;Provider;Public Health;Research;Resource-limited setting;Resources;Severities;standard of care;success;support tools;Tanzania;tool;Treatment Effectiveness;uptake;Validation;Work;World Health Organization

PROJECT_TITLE: External Validation and Implementation of a Novel Mobile Health Application for Acute Diarrhea Management across the Lifespan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Pain Research;Patient Safety;Physical Activity

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Blood flow restriction training (BFRT) is appealing as a rehabilitation strategy because it allows for strengthening with low exercise loads, but high-quality research is lacking, especially in patients with shoulder disorders. The proposed research is relevant to public health because it will inform decisions for designing a future rigorous large-scale efficacy trial on BFRT as a treatment for shoulder pain. The proposed project is relevant to the NIAMS’ mission to investigate the cause, treatment, and prevention of musculoskeletal diseases.

PI_NAMEs: POZZI, FEDERICO  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adherence;Adverse event;Area;arm;arm function;Blood flow;Clinical;clinical application;clinical practice;Clinical Practice Guideline;clinical trial implementation;clinically relevant;Complex;Data;Data Collection;design;Disease;Distal;effective intervention;efficacy trial;Elasticity;Enrollment;Evaluation;Exercise;exercise prescription;Exercise Tolerance;follow-up;Frequencies;Future;Goals;Growth Factor;Health;Hypertrophy;Impairment;Individual;infraspinatous muscle;Inguinal canal structure;innovation;Intervention;Interview;Lifting;Limb structure;Lower Extremity;Masks;Measures;medical attention;meetings;Mission;Modality;Monitor;Morphology;Movement;Muscle;muscle hypertrophy;muscle strength;Muscle Weakness;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Outcome;Pain;Participant;Pathologic;Patient Outcomes Assessments;Patients;Performance;pilot trial;Population;Prevalence;Prevention;Primary Care;primary care visit;primary endpoint;Procedures;Property;Protocols documentation;Public Health;quadriceps muscle;Qualifying;Randomized;randomized trial;Recommendation;Recovery;recruit;rehabilitation strategy;Research;Research Personnel;response;Risk;Rotator Cuff;Safety;safety and feasibility;secondary endpoint;Serious Adverse Event;Shoulder;Shoulder Pain;strength training;Stress;Structure;success;supraspinatus muscle;Symptoms;Tendon structure;Testing;Therapeutic;Thick;Time;Training;Translating;U-Series Cooperative Agreements;Ultrasonography;Upper Extremity;Visit;Withdrawal

PROJECT_TITLE: Blood flow restriction training for subacromial pain

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Precision Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: RAS mutations are currently used as a contraindicative biomarker for EGFR inhibitors. Our recent findings identified 11 RAS mutations that confer sensitivity to EGFR inhibitors in vitro, and targeting the WT RAS signaling is a mechanistic rationale that is both novel and beneficial to patients in the near term.

PI_NAMEs: MCFALL, THOMAS BRADLEY (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affinity;Alleles;Binding;Biological Markers;Biological Models;Biology;Bypass;cancer cell;cancer therapy;cancer type;candidate marker;Cell Proliferation;Cetuximab;Clinical;Clinical Trials;colon cancer patients;Colorectal Cancer;Combined Modality Therapy;Computer Models;Computing Methodologies;Data;Dependence;EGFR inhibition;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Exclusion;Frequencies;Genetic Models;Goals;Guidelines;In Vitro;in vivo Model;Individual;inhibitor therapy;KRAS2 gene;Ligand Binding;Malignant Neoplasms;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Mediator;molecular modeling;mutant;Mutation;neoplastic cell;NF1 gene;novel;Oncogenic;Outcome;Patients;personalized medicine;pharmacologic;Pre-Clinical Model;prevent;programs;Proliferating;RAS genes;ras Proteins;Ras Signaling Pathway;Reporting;Reproducibility;Research;Resistance;resistance allele;Role;Signal Transduction;System;Systems Biology;targeted agent;targeted biomarker;targeted treatment;Testing;treatment response;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;Work

PROJECT_TITLE: Redefining indications of EGFR inhibitors in cancers that harbor mutant RAS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCTC-S (01)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE (RELEVANCE) The proposed research is directly related to public health because understanding the genetic, molecular, and cellular mechanisms of esophageal squamous cell cancer initiation and progression is expected to give rise to new types of diagnoses, treatments, and preventions for esophageal squamous cell cancer. Thus, this study is relevant to the part of NIH’s mission that pertains to fostering fundamental creative discoveries and innovative research strategies as a basis for ultimately protecting health.

PI_NAMEs: PARK, JAE-IL  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Ablation;Animal Model;Basal Cell;Biological Markers;Biological Models;Biology;biomarker identification;cancer initiation;Candidate Disease Gene;CCL2 gene;CDKN2A gene;Cell Lineage;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Combinatorics;Communities;Creativeness;Detection;Development;Diagnosis;early detection biomarkers;Early Diagnosis;Esophageal Neoplasms;esophageal squamous cell cancer;Esophageal Squamous Cell Carcinoma;Esophagus;Event;exhaustion;Exhibits;FOSL2 gene;Fostering;Foundations;Gene Expression Profile;Genetic;Genetic Engineering;genetic manipulation;Genetic Transcription;Genetically Engineered Mouse;Goals;Health protection;Human;Human Resources;Immune;immune checkpoint;Immune checkpoint inhibitor;Immune Evasion;Immunocompetent;Immunologic Surveillance;In Vitro;in vivo;innovation;Invaded;Knock-out;Knowledge;Lamina Propria;Malignant neoplasm of esophagus;meetings;Mission;Modeling;Molecular;Mus;Mutation;Neoplasms;neoplastic;NOTCH1 gene;novel therapeutic intervention;novel therapeutics;NR2F6 gene;Organoids;Outcome;Pathology;Pathway interactions;Patients;Prevention;Prognosis;Public Health;Rattus;Regulon;Research;response;Role;Sampling;Symptoms;T-Lymphocyte;Testing;Therapeutic;therapy development;TP53 gene;transcriptomics;tumor;tumor progression;Tumor Suppressor Genes;tumorigenesis;United States National Institutes of Health

PROJECT_TITLE: Esophageal Squamous Cell Cancer Initiation and Immune Landscape Remodeling

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE For the gastrointestinal tract to function properly, the patterns of contractions in the muscle layers must be tightly regulated and coordinated. Normal contractile patterns in the gastrointestinal tract are dependent on a cell type called the interstitial cell of Cajal and on a transporter named SLC4A4, which is expressed in interstitial cells of Cajal. This proposal will study how the expression of SLC4A4 is regulated, how the transporter regulates electrical activity of the gastrointestinal tract, and how it contributes to both gastrointestinal health and disease.

PI_NAMEs: FARRUGIA, GIANRICO  (contact);ORDOG, TAMAS

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acids;Affect;base;Bicarbonates;Binding;Binding Sites;Calcium;Cell Line;cell type;Cells;cholinergic;cohort;Data;design;Development;differential expression;Disease;Endoplasmic Reticulum;Epigenetic Process;epigenome editing;epigenomic profiling;Evaluation;Family;Functional disorder;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;Gastrointestinal Stromal Tumors;Gastrointestinal tract structure;Gene Expression Regulation;gene function;Generations;Genes;Genetic;genome editing;genome wide association study;Genotype;Goals;Grant;Growth Factor;Health;Human;human model;in silico;In Vitro;in vivo;Individual;interstitial cell;Interstitial Cell of Cajal;Ion Channel;knock-down;Left;Link;Maps;member;Modeling;Motor;Mus;Muscle;Mutation;Names;neoplastic cell;neuroregulation;Organ;overexpression;Pacemakers;Pathway interactions;Patients;Pattern;Peristalsis;pharmacologic;Phase;phenome;Phenotype;phosphoproteomics;Phosphorylation;pre-clinical;Prevention;Protein Isoforms;Proteins;Receptor Protein-Tyrosine Kinases;Regulation;Regulatory Element;Renal tubular acidosis;Repression;Role;Sampling;screening;selective expression;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Small Intestines;Smooth Muscle;solute;symporter;trait;transcription factor;Transcriptional Regulation;transcriptomic profiling;Tumor Cell Line;Uncertainty;Untranslated RNA;voltage;Work

PROJECT_TITLE: Calcium Dynamics in Interstitial Cells of Cajal

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Although cortical glutamate synaptic impairments are considered a core pathophysiological feature underlying brain dysfunction in schizophrenia, the nature of these synaptic impairments in schizophrenia is almost completely unknown. This project investigates the schizophrenia disease effect on presynaptic, postsynaptic and mitochondrial ultrastructural correlates of function at individual glutamate synapses using a focused ion beam- scanning electron microscopy approach, and molecular perturbations underlying these findings using a synaptosome proteomic approach, in postmortem human brain. These studies will determine the structural and molecular bases of cortical glutamatergic synaptic impairments in schizophrenia to inform functional and molecular therapeutic targets.

PI_NAMEs: GLAUSIER, JILL RENEE' (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: 3-Dimensional;ATP Synthesis Pathway;Autopsy;base;Brain;brain dysfunction;brain tissue;Categories;cohort;Communication;Crista ampullaris;density;differential expression;Disease;Docking;Electrons;Etiology;Exhibits;Functional disorder;Future;Genetic;Genetic study;glutamatergic signaling;Glutamates;Human;Image;Impaired cognition;Impairment;in vivo;indexing;Individual;insight;Ions;macula;Maps;Mass Spectrum Analysis;Measures;Microscopic;Mitochondria;Mitochondrial Proteins;Molecular;Molecular Abnormality;molecular targeted therapies;Morphology;nanometer resolution;Nature;neural;neurotransmission;novel strategies;Pathway interactions;Physiological;postsynaptic;Prefrontal Cortex;Preparation;presynaptic;Presynaptic Terminals;prevent;Process;Proteins;Proteome;Proteomics;receptor;reconstruction;Resolution;response;Scaffolding Protein;Scanning Electron Microscopy;Schizophrenia;Signal Transduction;Structural defect;Structure;Synapses;synaptic function;Synaptic Vesicles;Synaptosomes;Three-Dimensional Imaging;Vertebral column;Vesicle;Visualization

PROJECT_TITLE: Basis of Glutamatergic Synaptic Dysfunction in Schizophrenia

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative The mechanisms that influence fibrosis in the heart after injury are poorly understood. This project will assess how changes in metabolism in fibroblasts influence the response of the heart to myocardial infarction.

PI_NAMEs: HILL, BRADFORD GUY (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acceleration;Alternative Splicing;Amino Acids;Anabolism;Biochemical Pathway;Carbon;Cardiac;Cicatrix;Citric Acid Cycle;Collagen;coronary fibrosis;Data;Deposition;Development;Enzymes;Extracellular Matrix;Fibroblasts;Fibrosis;Glutamine;Glycine;Glycolysis;Heart;Heart Injuries;Hour;improved;In Vitro;in vivo;Injury;manufacturing capabilities;Mediating;Metabolic;Metabolic Pathway;Metabolism;Modeling;Myocardial Infarction;Myofibroblast;Pathway interactions;pharmacologic;Phenotype;Phosphoenolpyruvate;Phosphoenolpyruvate Carboxylase;Play;Process;Procollagen;Production;Proline;Protein Isoforms;Pyruvate Kinase;response;RNA Splicing;Role;Serine;Stimulus;Structure;Testing;Transforming Growth Factor beta;translational potential;Variant

PROJECT_TITLE: Role of the PEP cycle in cardiac fibrosis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative We have developed a group of novel anticancer chemicals, curaxins, which are currently tested in clinic; they act via disrupting of packaging of genetic material, DNA, in tumor cells. Contrary to exiting drugs targeting DNA they do not cause mutations. We recently identified a new feature of these compounds that they can activate immune response against tumors; in this proposal we will figure out how they do this and how we can utilize this property in the clinic to get maximal benefit for patients.

PI_NAMEs: GUROVA, KATERINA V (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Aggressive behavior;anti-cancer;anti-tumor immune response;anticancer activity;Antineoplastic Agents;B-DNA;Binding;biomarker identification;cancer therapy;cancer type;cell stroma;cell type;Cells;Characteristics;Chemicals;chemotherapy;Chemotherapy-Oncologic Procedure;Chromatin;Clinic;Clinical;Data;Disease;DNA;DNA Damage;DNA Methyltransferase Inhibitor;Dose;Drug Targeting;Environment;experimental study;Future;Genes;Genetic Materials;Goals;Histone Deacetylase Inhibitor;Human;Immune;Immune checkpoint inhibitor;Immune response;Immunity;immunogenicity;Immunotherapy;improved;in vivo;Interferon Activation;Interferon Type I;Interferons;Knowledge;Lead;Left;Mainstreaming;Malignant Neoplasms;Mediating;Modeling;Monitor;mouse model;Mus;Mutation;neoplastic cell;next generation;novel;Nuclear;Nucleosomes;Patients;Pattern recognition receptor;Pharmaceutical Preparations;phase I trial;predictive marker;Proliferating;Property;Regimen;Research;Resistance;response;Rest;Role;Sampling;sensor;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Technology;Testing;Time;Toxic effect;Transcript;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;Z-DNA Binding Protein;Z-Form DNA

PROJECT_TITLE: Induction of interferon response by chromatin damaging anti-cancer therapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer

PHR: PROJECT NARRATIVE Lung cancer relapses in over half of all treated patients; relapsed disease does not respond well to current therapies including those directed at boosting the body’s immune response against the tumor. We and others determined that a protein called STAT3 promotes the growth and survival of lung cancer cells and blocks tumor immunity. We have developed a safe drug that effectively targets STAT3 that we propose to test in this proposal for benefit in mouse models and patients with lung cancer.

PI_NAMEs: MOGHADDAM, SEYED JAVAD MIRHASSANI;SKOULIDIS, FERDINANDOS ;TWEARDY, DAVID JOHN (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: A549;Accounting;Adverse event;Aftercare;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;Antisense Oligonucleotides;Apoptotic;autocrine;Biological Availability;Biopsy;Biotechnology;Cancer cell line;Cancer Etiology;Cancer Patient;Cancer Relapse;cancer therapy;cell growth;Cessation of life;checkpoint therapy;chemotherapy;Clinical;clinical development;clinical practice;Computers;Correlative Study;Country;design;Development;Disease;Docking;Dose;Dose Limiting;Drug Kinetics;Enrollment;Epidermal Growth Factor Receptor;Evaluable Disease;Event;Failure;gain of function mutation;Grant;Growth;Human;Immune;Immune checkpoint inhibitor;immune resistance;Immune response;Immunocompetent;Immunotherapy;improved;improved outcome;inhibitor;Interleukin-6;K-ras mouse model;KRAS2 gene;Lead;Lung;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;men;Messenger RNA;Minority;Molecular Abnormality;molecular targeted therapies;mouse model;Mus;mutant;mutant mouse model;Mutate;Mutation;Myeloid-derived suppressor cells;neoplastic cell;new therapeutic target;Newly Diagnosed;Non-Small-Cell Lung Carcinoma;Nuclear;Nude Mice;Oncogenic;Oral;Outcome;partial response;participant enrollment;Pathway interactions;Patients;PD-1/PD-L1;PDL1 inhibitors;pembrolizumab;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 1 study;phase 2 designs;phase 2 study;Phase Ib/II Clinical Trial;phase II trial;Phosphorylation;Proteins;Publishing;Recommendation;Recurrence;Recurrent disease;Refractory;Research;Research Design;Resected;Resistance;response;ROS1 gene;Safety;Sampling;Serious Adverse Event;Signal Transduction;small molecule;Solid Neoplasm;STAT3 gene;Stat3 protein;STK11 gene;Testing;Therapeutic;Toxic effect;transcription factor;translational goal;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Tyrosine;Woman;Xenograft procedure

PROJECT_TITLE: Targeting non-small cell lung cancer cells and the adverse tumor microenvironment with a small-molecule STAT3 inhibitor

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Women's Health Research

PHR: Project Narrative Using both tobacco and cannabis during pregnancy is more common in minoritized groups and can make quitting smoking in pregnancy and remaining smoke free postpartum difficult. Because depression symptoms are addressable and are also related to experiences of discrimination and trauma, we will collaborate with people from marginalized identities to understand the ways in which depressive symptoms relate to using tobacco and cannabis during pregnancy. We will then co-develop and test an intervention to address prenatal depressive symptoms to encourage people to quit tobacco and cannabis during pregnancy and stay quit postpartum.

PI_NAMEs: DE GENNA, NATACHA  (contact);LEVINE, MICHELE D

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: acceptability and feasibility;Address;Affect;antepartum depression;Behavioral;Black Populations;Black race;Cannabis;cannabis cessation;Child Rearing;Cigarette;cigarette smoking;Code;Collaborations;common symptom;Communities;Data;depressive symptoms;design;Discrimination;efficacy evaluation;Elements;experience;feasibility trial;Future;Health;health equity;Individual;Inequity;Infant;interest;Intervention;intervention mapping;Interview;Link;Lived experience;marginalization;marginalized population;Marijuana Smoking;marijuana use;marijuana use in pregnancy;Measures;member;Mental Depression;Methods;Minority Groups;Needs Assessment;neonatal outcome;Not Hispanic or Latino;novel;perceived discrimination;Perinatal;perinatal depressive symptom;perinatal period;Persons;poor health outcome;Population;post pregnancy;Postpartum Period;Pregnancy;pregnant;prenatal;prenatal experience;prenatal health;Prevention program;Process;Public Health;Race;reduce tobacco use;Relapse;relapse prevention;Research;response;Risk;Role;sexual minority;Smoke;smoking cessation;Smoking Cessation Intervention;smoking during pregnancy;social;social stigma;standard measure;Stress;substance use;success;successful intervention;Symptoms;Testing;Text;therapy design;therapy development;Tobacco;tobacco abstinence;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;Trauma;treatment research;Voice;vulnerable community;Withdrawal;Work

PROJECT_TITLE: Partnering with Pregnant and Postpartum People to Co-Create a Novel Intervention to Reduce Tobacco and Cannabis Use

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Sleep Research;Stimulant Use and Misuse;Substance Misuse

PHR: Narrative This proposal will characterize a novel sleep EEG-based signature that closely reflects MCH neuron activities in vivo. Expected results will reveal novel biomarkers from this EEG feature that are uniquely quantifiable, providing versatile possibilities for predicting different aspects of drug-seeking behaviors.

PI_NAMEs: HUANG, YANHUA H (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Adolescence;Adult;Affect;Behavior;behavior measurement;behavioral outcome;Biological Markers;Cocaine;cocaine craving;cocaine exposure;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine withdrawal;Cues;Darkness;Data Set;design;drug relapse;drug seeking behavior;drug withdrawal;Electroencephalography;Exhibits;experience;experimental study;Female;Fire - disasters;Frequencies;Functional impairment;Genetic;Glutamates;Healthcare;Heterogeneity;Hippocampus;Human;Hypothalamic structure;Impairment;improved;in vivo;Incubated;Intake;Intervention;Label;Lateral;Lead;Machine Learning;male;Measures;Medial;Medical;melanin-concentrating hormone;Membrane;Mental disorders;Modeling;Monitor;Neurons;neurophysiology;non-invasive monitor;novel;novel marker;Nucleic Acid Regulatory Sequences;Nucleus Accumbens;optogenetics;Outcome;Pharmaceutical Preparations;Phase;Population;potential biomarker;predictive marker;Publishing;Rattus;Recovery;recruit;Relapse;REM Sleep;Reporting;Research;research and development;restoration;reward circuitry;reward processing;Role;Severities;sex;Signal Transduction;Sleep;sleep abnormalities;Sleep Deprivation;Sleep disturbances;Sleep Fragmentations;Structure;substance use;Substance Use Disorder;success;Surface;temporal measurement;Testing;therapeutic development;therapeutic effectiveness;Time;Training;translational potential;transmission process;United States National Institutes of Health;Withdrawal;zona incerta

PROJECT_TITLE: Developing a sleep EEG-based biomarker for drug relapse propensity


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Our goal is to develop a novel in-plane IVUS/fiber optic imaging-integrated fine needle/ balloon catheter system for TIPS creation. Tests of the fine needle/balloon system in pig cadavers for TIPS creation resulted in 100% success of placing a 5Fr.catheter in portal vein from the right hepatic vein. This IVUS/fiber optic borescope-incorporated fine needle(22G)/balloon catheter system is expected to significantly lower the risk and difficulties of TIPS techniques, which will ultimately increase the availability of TIPS treatment and benefit millions of patients with decompensated cirrhosis, particularly those in underdeveloped countries.

PI_NAMEs: ZHANG, FENG  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: Acute;Address;Adult;Ascites;Cadaver;cancer diagnosis;cancer therapy;Catheters;Cessation of life;Child;chronic liver disease;Cirrhosis;Clinical;clinical application;clinical translation;Complication;design;Developing Countries;Development;Devices;Esophageal Varix;experience;experimental study;Extrahepatic;Failure;Family suidae;Fiber Optics;Future;Goals;Hemorrhage;hepatic vein;high risk;Human;image guided;improved;Incidence;innovation;Intervention;Interventional radiology;intrahepatic;intraperitoneal;invention;kidney dysfunction;Laboratories;Life;Liver;Liver Cirrhosis;Micropuncture;mortality;Needles;novel;optical imaging;Patients;Portal Hypertension;Portal vein structure;Procedures;Protocols documentation;prototype;Puncture procedure;Radiation;radiologist;Recurrence;reduce symptoms;Refractory;Risk;Rupture;Series;Shunt Device;Specimen;Standardization;success;Surgical Portosystemic Shunt;System;Techniques;Testing;Transjugular intrahepatic portosystemic shunt procedure;Translating

PROJECT_TITLE: Development of Optical Imaging/IVUS-Guided Micropuncture System for TIPS Creation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Reward-associated cues are essential for adaptive decision making and contribute to maladaptive states, such as addiction. Critically, not all individuals respond in the same way to cues, producing unique vulnerability trajectories to psychiatric disease. Here, we investigate the behavioral and neurobiological mechanisms of individual variability in sensory-guided reward learning and addiction-like behaviors.

PI_NAMEs: SAUNDERS, BENJAMIN THOMAS (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Amygdaloid structure;Animals;approach behavior;Association Learning;Behavior;Behavioral Mechanisms;Biosensor;Brain;Cocaine;cocaine self-administration;Complex;Corpus striatum structure;Cues;Decision Making;Development;Disease;Dopamine;Dopamine Receptor;dopaminergic neuron;Drug Addiction;Drug Delivery Systems;drug relapse;Emotional;Fiber;Food;Goals;Impairment;in vivo;Individual;Individual Differences;individual variation;Infusion procedures;Intake;integration site;Learning;learning strategy;Location;Measurement;Mental disorders;Modality;Modeling;neurobiological mechanism;neuromechanism;Neurons;Nose;Nucleus Accumbens;optogenetics;Pattern;Pharmaceutical Preparations;Photometry;Procedures;Rattus;Relapse;response;Rewards;Role;Self Administration;Sensory;sensory integration;Signal Transduction;Site;Smell Perception;sound;Stimulus;Testing;Training;trait;Transgenic Organisms;Vision

PROJECT_TITLE: Basolateral amygdala dopamine in addiction-related learning strategies

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Bioengineering;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Services;Hepatitis;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prevention;Primary Health Care

PHR: PROJECT NARATIVE The proposed research is relevant to public health because it will use innovative methods to incorporate predictors from longitudinal data, collected in routine clinical practice, into models that diagnose NAFLD and predict future risk of liver events, such as cirrhosis and related complications. Lack of screening methods in current clinical practice and absence of symptoms until late-stage lead to delayed diagnosis and poor patient outcomes; therefore, early diagnosis and prediction of disease trajectory at primary care level will enable timely intervention and selection of patients who need specialized testing and hepatology referral. The project is relevant to the NIDDK’s mission because it will create a sound clinical pathway management for the most common chronic liver disease affecting 80-100 million US adults, which will ultimately decrease health care burden and improve population outcomes.

PI_NAMEs: ALLEN, ALINA M (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Adult;Affect;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Biopsy;Calibration;Caring;Cessation of life;chronic liver disease;Cirrhosis;Clinical;clinical decision-making;clinical heterogeneity;Clinical Pathways;clinical phenotype;clinical practice;clinically significant;cohort;Communities;County;Data;Data Analytics;data integration;Data Science;Data Set;Databases;demographics;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Management;Disease Outcome;disease phenotype;Disease Progression;disorder control;disorder risk;Early Diagnosis;Early identification;elastography;Electronic Health Record;electronic health record system;Enrollment;Epidemiology;Evaluation;Event;Fatty acid glycerol esters;Fibrosis;follow-up;Future;General Population;Goals;Health;health care settings;Healthcare;healthcare burden;Hepatology;improved;Individual;innovation;Intervention;Laboratories;Lead;Liver;liver biopsy;Liver diseases;liver transplantation;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of liver;Measures;Methods;Minnesota;Mission;model development;Modeling;Morbidity - disease rate;mortality;mortality risk;multimodality;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Outcome;Pathway interactions;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Performance;personalized intervention;Pharmaceutical Preparations;Phenotype;Population;population based;population health;Population Research;predictive modeling;prevent;Primary Care;primary care practice;Process;prophylactic;prospective;Prospective cohort;Public Health;Recording of previous events;Research;Resources;Risk;risk stratification;screening;Severity of illness;Statistical Methods;Steatohepatitis;Symptoms;System;Testing;Therapeutic Intervention;tool;Training;Validation;Work

PROJECT_TITLE: NAFLD Diagnosis and Outcomes

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Genetic, biochemical, and model organism studies indicate that genetic variants in the gene encoding the signaling protein TRIO contribute to the pathology of schizophrenia, autism spectrum disorders (ASD), and intellectual disability (ID). Our analysis of a cluster of variants associated with ASD and ID has identified a mechanism that controls TRIO signaling ability. Our proposal aims to identify small molecule compounds that can modulate this key signaling function to use as probes to understand how TRIO works and how disrupting TRIO function impairs brain development, paving the way for validation of TRIO as drug target and for future therapeutics development for neurodevelopmental disorders.

PI_NAMEs: KOLESKE, ANTHONY J (contact)

PROGRAM_OFFICER_NAME: MANDELBLAT-CERF, YAEL

PROJECT_TERMS: Address;Affinity;Alleles;Anxiety;autism spectrum disorder;Binding;Biochemical;Biological Assay;Biosensor;Brain;brain dysfunction;Cells;Cellular Morphology;Characteristics;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Data;de novo mutation;Defect;Dendrites;Dendritic Spines;design;Development;Developmental Delay Disorders;Disease;Dose;Drug Targeting;Dryness;Elements;Family;Fluorescence;follow-up;Future;Genes;Genetic;genetic risk factor;genetic variant;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterozygote;high throughput screening;impaired brain development;Impairment;In Vitro;Individual;individuals with autism spectrum disorder;inhibitor;Intellectual functioning disability;Interferometry;Lead;Length;Libraries;Link;loss of function;Measures;Mediating;model organism;Molecular;motor impairment;Mus;Neurodevelopmental Disorder;neuron development;Neurons;Noise;novel;novel therapeutic intervention;paralogous gene;Pathologic;Pathology;Pathway interactions;Penetration;Pharmaceutical Preparations;Physiological;Powder dose form;Property;Protein Isoforms;Proteins;Recombinants;Regulation;Reproducibility;response;rho;Risk;Running;Schizophrenia;schizophrenia risk;Series;Signal Pathway;Signal Transduction;Signaling Protein;Slice;small molecule;Social Interaction;Spectrin;Substrate Specificity;Surface Plasmon Resonance;Symptoms;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;targeted treatment;Testing;therapeutic development;Therapeutic Effect;Tissues;tool;Toxic effect;Translating;TRIO gene;Validation;Variant;Work

PROJECT_TITLE: Identification and characterization of chemical probes of TRIO GEF1 activity

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ORG_CITY: LOS ANGELES

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Spatial transcriptomics technology enables structure-function analysis of tissues at single-cell resolution producing atlases with a broad impact on many biomedical research areas, yet, despite tremendous technological progress in spatial transcriptomics, all existing spatial transcriptomics technologies are limited to thin 2D sections. We propose to develop a new approach for whole organ spatial transcriptomics based on the integration of new ﬂuorescent in situ hybridization technology we invented, scRNAseq reference, and light-sheet microscopy. We will demonstrate the new technology by creating a complete cell type and gene expression atlases of the whole mouse brain.

PI_NAMEs: LI, JINGYI JESSICA ;WOLLMAN, ROY  (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: 3-Dimensional;Algorithms;Anatomy;Area;Atlases;Bar Codes;Benchmarking;Biological Assay;Biology;Biomedical Research;Biopsy;Brain;brain cell;cell type;Cells;Classification;combinatorial;Computer software;cost;Data;design;Development;Developmental Biology;Diagnostic;Dimensions;Discipline;DNA;experimental study;flexibility;Fluorescence;Fluorescent in Situ Hybridization;Gel;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Goals;Hippocampal Formation;Hydrogels;Image;In Situ Hybridization;in situ sequencing;Individual;invention;Label;Learning;Legal patent;Light;Maps;Measurement;Measures;meter;Methods;Microscope;Microscopy;Microtomy;Molecular;Mus;Neocortex;neural network;Neurosciences;new technology;novel strategies;Oncology;Optics;Organ;Patients;Pattern;Penetration;Performance;Physiology;Property;Protocols documentation;reconstruction;Resolution;RNA;Sampling;Scanning;Signal Transduction;single molecule;single-cell RNA sequencing;Stains;Statistical Methods;Structure;Sum;System;Techniques;Technology;terabyte;Testing;Thick;Thinness;Time;Tissues;transcriptome;transcriptomics;Update;Validation;Variant;Work

PROJECT_TITLE: Whole organ transcriptome reconstruction by dimensionality reduced fluorescent in situ hybridization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-A (02)]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Thousands of hospitalized Veterans receive inappropriate antibiotic treatment with a class of antibiotics known as “anti-anaerobic” antibiotics. Recent research suggests that this class of antibiotics is particularly disruptive to the gut microbiome and that this disruption may increase mortality in hospitalized Veterans. This proposal will use a big-data analysis of electronic medical record data to determine if anti-anaerobic antibiotics may increase mortality in hospitalized Veterans. It will also look at the impact of anti-anaerobic antibiotics on the microbiome and inflammation in hospitalized Veterans. As a result of this research, physicians can make better decisions about their antibiotic use and avoid harm related to antibiotic treatment. This research will also support the training and development of Dr. Rishi Chanderraj, a VA researcher who will combine big-data analysis, advanced statistical methods, and molecular techniques to improve our understanding of the impact of antibiotic treatment on the microbiome and Veteran health.

PI_NAMEs: CHANDERRAJ, RISHI  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;Anaerobic Bacteria;Anatomy;Antibiotic Therapy;Antibiotics;antimicrobial;Atherosclerosis;Bacteria;Big Data;Big Data Methods;Biological;biomarker validation;Biometry;career development;Caring;Cefepime;Cessation of life;Circulation;Cirrhosis;Clinical;clinical center;Clinical Data;Clinical Management;Clinical Research;Clinical Sciences;Clinical Treatment;Communicable Diseases;Communities;Computerized Medical Record;COVID-19 pandemic;Data;Data Analyses;data warehouse;Development;digital;Disease;Enterobacteriaceae;Enterobacteriaceae Infections;Environment;experience;Foundations;Future;Goals;Growth;gut microbiome;Health;Hospitalization;host microbiome;Immune response;Immunologics;improved;Infection;Inflammation;Interleukin-6;International;intestinal fatty acid binding protein;Intestinal permeability;Intestines;Knowledge;Learning;Length of Stay;lipopolysaccharide-binding protein;Malignant Neoplasms;Master of Science;Measures;Mentors;Mentorship;Metabolic;Methods;Michigan;microbiome;microbiome composition;microbiome research;microbiota;Modeling;Molecular;mortality;Natural experiment;Nosocomial Infections;Organ;Outcome;Pathogenicity;patient oriented;Patients;Pharmaceutical Preparations;Physicians;Physiological;Physiology;Piperacillin-Tazobactam;Positioning Attribute;prospective;Prospective Studies;Prospective, cohort study;Publishing;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Priority;Resources;Retrospective cohort study;Sampling;Serum;Shock;Site;skills;Skin;Statistical Methods;systemic inflammatory response;Techniques;Testing;Time;Training;Training Support;Translating;translational pipeline;Translational Research;treatment optimization;Universities;Upper respiratory tract;Veterans;Work

PROJECT_TITLE: Impact of anti-anaerobic antibiotics on clinical outcomes and the microbiome in hospitalized Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 INFB-K (01)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Relevance NK cells are powerful immune cells that kill infected and cancerous cells by secreting lytic granules onto their surface. The proposed work seeks to convert these cells from “one cell at a time”, directional killers into killers that can eradicate multiple diseased cells at a time by releasing granules in multiple directions. We propose strategies to alter modes of killing as well as new high-resolution systems to observe and test killing in complex 3-dimensional tumor environments with the ultimate goal of improving NK cell therapies for cancer.

PI_NAMEs: ORANGE, JORDAN SCOTT (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 3-Dimensional;Actins;Biological;Biological Assay;Biological Models;cancer cell;cancer therapy;Cancerous;Candidate Disease Gene;Cell Communication;Cell Degranulation;cell killing;Cell Line;Cell Physiology;Cell secretion;Cell Therapy;Cells;Cellular biology;Cellular immunotherapy;Charge;Clinical;Complex;CRISPR library;Custom;Cytoplasmic Granules;cytotoxic;cytotoxicity;Data;Dependence;design;Diagnosis;Disease;Dynein ATPase;Effectiveness;Environment;exhaustion;experimental study;Feeling hopeless;Future;Genes;Genetic Screening;Goals;Human;human disease;Hydrogels;Immune;immunological synapse;Immunotherapy;improved;Individual;inhibitor;insight;interest;Investigation;Laboratories;Learning;Libraries;live cell imaging;Lymphocyte;Lytic;Malignant Neoplasms;Maps;Mechanics;Mediating;Medical;Methods;Microtubule-Organizing Center;Modeling;Motor;Movement;Mutation;Natural Killer Cells;neoplastic cell;NK cell therapy;novel;Organelles;Pathogenicity;Pathologic;Patients;perforin;Physiological;Positioning Attribute;prevent;Process;programs;Proliferating;Proteins;Publications;Radial;Resistance;Resolution;Resources;Secretory Cell;Series;Signal Transduction;small molecule;small molecule inhibitor;Solid Neoplasm;Surface;Synapses;synaptic function;System;Testing;Therapeutic;Time;Tissues;tool;tumor;Tumor Promotion;Virus;Work

PROJECT_TITLE: Directing Function at the Natural Killer Cell Secretory Immunological Synapse

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Diabetes;Natural Products;Pediatric;Prevention

ORG_CITY: TAMPA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: 8. Project Narrative Type 1 diabetes (T1D) is an autoimmune disease of increasing incidence resulting in the loss of pancreatic β- cells and lifelong dependency on exogenous insulin with only one recently approved preventative measure to marginally delay onset. Our preliminary evidence indicates Cornus officinalis (CO), an herbal medicine, can promote pancreatic β-cell survival via promotion of Nrf2 and autophagy, stimulate antioxidant pathways and inhibit onset of T1D in the non-obese diabetic (NOD) mouse. Therefore, this proposal aims to determine clinical efficacy in-vivo by elucidating the biological mechanism of CO to be utilized as a therapeutic option for T1D interventional therapy.

PI_NAMEs: BURKHARDT, BRANT ROGER (contact);STEVENS, STANLEY M

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;Adult;Animal Model;Anti-diabetic Drugs;Antioxidants;Appearance;Autoimmune Diseases;Autoimmunity;Autophagocytosis;Beta Cell;Biological;Cell Death;Cell Line;Cell Physiology;Cell Survival;Cells;Child;Clinical;clinical efficacy;Cornus;cytokine;cytotoxic;Dependence;design;Development;diabetes pathogenesis;diabetic;Disease;drug development;drug resource;Early treatment;Ethnopharmacology;Experimental Designs;Female;GATA1 gene;Genes;Genetic Predisposition to Disease;Glucose;Glutamate-Cysteine Ligase;Glutathione Reductase;heme oxygenase-1;Herbal Medicine;Human;Hyperglycemia;In Vitro;in vivo;Inbred NOD Mice;Incidence;innovation;Insulin;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;insulitis;interdisciplinary approach;Intervention;islet;Literature;male;Measures;Mediating;Methods;Modality;Modeling;Molecular;Mus;Non obese;novel;nuclear factor-erythroid 2;Nuclear Translocation;Oral;Oral Examination;Oxidative Stress;Pancreas;Pathogenesis;Pathway interactions;Patients;pharmacologic;Pharmacologic Actions;Plant natural product;pre-clinical;predictive marker;preservation;prevent;preventive intervention;Preventive measure;Preventive treatment;Production;protein expression;Proteins;Proteomics;Reactive Oxygen Species;Reading;Reporting;Research;Research Design;Role;Signal Pathway;Signal Transduction;SOD2 gene;Source;Streptozocin;Structure of beta Cell of islet;Symptoms;Technology;Therapeutic;therapeutic candidate;Therapeutic Intervention;Toxic effect;transcription factor;treatment group;United States;Water

PROJECT_TITLE: C. officinalis induction of Nrf2 inhibiting type 1 diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: LEXINGTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KENTUCKY

PHR: We are proposing to further develop a percutaneous cavopulmonary assist system toward clinical application. The enabling technology is a cavopulmonary assist dual lumen cannula with paired membrane umbrellas. Our cavopulmonary assist system will provide total ambulatory support to cavopulmonary failure patients, bridging these patients with failing Fontan circulation to recovery, reconstructive surgery, and heart transplantation to improve outcomes.

PI_NAMEs: WANG, DONGFANG  (contact);YOGANATHAN, AJIT P

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: 3-Dimensional;Acute;Anatomy;Area;biomaterial compatibility;Blood;Cannulas;Cannulations;Catheters;Circulation;clinical application;clinical efficacy;clinically relevant;Common Ventricle;Data;Databases;design;Development;Dislocations;Eligibility Determination;Ensure;Failure;flexibility;Functional disorder;Glycerol;Goals;Grant;Heart;Heart Transplantation;hemodynamics;Hemolysis;Hypoxia;Implantable Pump;improved outcome;In Vitro;in vivo;Inferior vena cava structure;Infusion procedures;Kentucky;kidney dysfunction;Liquid substance;Live Birth;Liver;Lung;Magnetic Resonance Imaging;Massachusetts;mathematical model;Medical Device;Membrane;Modeling;Molds;mortality;novel;Operative Surgical Procedures;Organ;Palliative Surgery;Patient Simulation;Patients;Performance;Polyurethanes;pre-clinical;preclinical study;pressure;prevent;prototype;Pulmonary artery structure;Pump;Reconstructive Surgical Procedures;Recovery;Rotation;Self-Help Devices;shear stress;Sheep;sheep model;Silicones;simulation;Single ventricle congenital heart disease;Superior vena cava structure;System;Technology;Testing;thrombogenesis;Thrombosis;Universities;Venous;Ventricular;ventricular assist device;Work

PROJECT_TITLE: Development of a Percutaneous Double Lumen Cannula-Based Cavopulmonary Assist System Toward Clinical Application


ORG_CITY: HERSHEY

ORG_DEPT: PATHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: NARRATIVE The bacterial endosymbiont Sodalis glossinidius has been regarded as a promising paratransgenic agent for the expression of anti-trypanosome effector molecules in tsetse flies (Glossina species). This proposal seeks to understand the molecular basis of this symbiotic relationship by establishing how Sodalis glossinidius interacts with insect cells and maintains a persistent infection in the tsetse host.

PI_NAMEs: PONTES, MAURICIO HENRIQUES (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Affect;African Trypanosomiasis;Amino Acids;Animals;Apoptosis;Bacteria;Bacterial Genes;Bacterial Proteins;Bacteriophages;Behavior;Benign;Binding;Biology;Cell Density;Cell Physiology;cell type;Cells;chronic infection;Coculture Techniques;Copulation;CRISPR/Cas technology;Cytoplasm;Cytosol;density;Development;Diptera;DNA;endosymbiont;Environment;Eukaryotic Cell;experimental study;extracellular;Fat Body;Female;fitness;fly;Future;Gene Modified;gene product;Genes;Genetic;Genetic Code;Genome;genome-wide;Glossinidae;Gram-Negative Bacteria;Hemolymph;host colonization;Human;Immune response;Immune signaling;Impairment;In Vitro;Insecta;Invaded;Knowledge;Label;Larva;Libraries;Life;male;Membrane;Methods;Midgut;Milk;Modification;Molecular;Multiprotein Complexes;Muscle;Mutagenesis;mutant;novel;Nutrient;Organism;paratransgenesis;Pathway interactions;Phagocytosis Inhibition;Physiology;Population;Procedures;Process;Protein Secretion;Protein translocation;Proteins;Protozoa;reproductive organ;Resources;reverse genetics;Salivary Glands;Stress;Symbiosis;Techniques;Tissues;tool;trafficking;transmission process;Trypanosoma;Tsetse Flies;Type III Secretion System Pathway;uptake;vector

PROJECT_TITLE: Genetics and physiology of the tsetse fly bacterial endosymbiont Sodalis glossinidius

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]