ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cocaine;Drug Abuse (NIDA only);Endocannabinoid System Research;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MILWAUKEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative The contribution of stress to relapse is complex and varies across individuals based on the severity of their substance use disorder. This proposal explores a novel mechanism through which stress promotes cocaine seeking in response to relapse triggers via glucocorticoid-regulated endocannabinoid signaling and altered synaptic transmission in the prefrontal cortex. Further the proposal examines how the influence of stress on cocaine seeking can intensify with excessive cocaine use, due to the recruitment of processes that regulate relapse-related circuitry.

PI_NAMEs: HILLARD, CECILIA J;MANTSCH, JOHN R. (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: 2-arachidonylglycerol;addiction;attenuation;Brain;Cells;Cholecystokinin;Clinical;CNR1 gene;Cocaine;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Complex;Corticosterone;Corticotropin-Releasing Hormone;craving;Disinhibition;dopaminergic neuron;Dose;drug seeking behavior;Electrophysiology (science);endocannabinoid signaling;Endocannabinoids;Female;Fiber;G alpha q Protein;gamma-Aminobutyric Acid;Genetic;Glucocorticoid Receptor;Glucocorticoids;hippocampal pyramidal neuron;Individual;Intake;Interneurons;Intervention;Label;maladaptive behavior;male;Mediating;Membrane;Modeling;Molecular;neuroadaptation;Neurons;novel;novel therapeutics;Nucleus Accumbens;Output;Pathologic;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacology;Photometry;Prefrontal Cortex;Process;Rattus;receptor;recruit;Regulation;Relapse;relapse risk;Reporter;response;restraint;risk minimization;Self Administration;Severities;Signal Pathway;Signal Transduction;Signaling Protein;Site;Stimulus;Stress;stressor;Substance Use Disorder;Synaptic Transmission;Testing;Ventral Tegmental Area;Work

PROJECT_TITLE: Mechanisms underlying the influence of stress on drug-seeking behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-S(02)M]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: EMERGENCY MEDICINE

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. Project Narrative Drug use and addiction is a major cause of illness/injury and mortality and patients with or at risk for substance use disorders typically receive medical care for acute consequences and complications of substance use and chronic conditions in medical settings such as emergency departments, primary and specialty care clinics. Thus, these diverse medical settings offer a critical opportunity to prevent and treat drug use and addiction. This proposal seeks to provide intensive research training and career development for a diverse cadre of physician scientists representing multiple disciplines including Emergency Medicine, General Internal Medicine/HIV/Hepatology/Pulmonary, Pediatrics/Adolescent Medicine and Obstetrics and Gynecology, to improve patient outcomes through prevention and treatment in medical settings.

PI_NAMEs: D'ONOFRIO, GAIL  (contact);O'CONNOR, PATRICK

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Accident and Emergency department;Acute;addiction;Address;Adolescent Medicine;Advisory Committees;AIDS prevention;career development;Caring;Chronic;Clinic;Clinical;community partners;Complex;Discipline;Discipline of obstetrics;Disparity;Drug Addiction;Drug usage;Educational Curriculum;Emergency Medicine;Ensure;equity, diversity, and inclusion;experience;Faculty;faculty research;Funding;Future;Gynecology;health equity;Health Sciences;Hepatology;HIV;improved;Internal Medicine;Intervention;Knowledge;Leadership;life span;Lung;Medical;medical specialties;Medicine;Mentors;multidisciplinary;novel;novel strategies;Outcome;Patient-Focused Outcomes;Patients;Pediatrics;Physicians;Population;Prevention;Prevention Research;Primary Care;Program Development;programs;Publishing;recruit;Research;Research Personnel;Research Priority;Research Training;Scholars Program;Scientist;Seasons;skills;substance use;Substance Use Disorder;success;synergism;Time;Training;Woman

PROJECT_TITLE: Yale-Drug use, Addiction, and HIV prevention Research Scholars (Yale-DAHRS)

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: Project Narrative A recent exciting development in cancer therapy involves using a patient’s own immune system to attack the cancer. The attack is accomplished by “killer CD8” T-cells that enter and destroy the malignant cells. To mount an effective attack, killer T cells need to be present in sufficient quantities and be able to renew themselves, and pathways that prevent their function need to be blocked. Some years ago, we discovered that “TET” proteins modify DNA; more recently, we showed that reducing TET protein function in T cells improves anti-cancer responses. Here we will study mouse and human T cells that infiltrate tumors to investigate how this happens, in a project very relevant to cancer immunotherapy.

PI_NAMEs: RAO, ANJANA  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Alleles;alpha ketoglutarate;anti-cancer;anti-PD-1;anti-PD-L1;Antibodies;Antigens;Antitumor Response;Biological Process;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;CAR T cell therapy;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Proliferation;Cell Surface Receptors;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic;chronic infection;Chronic Lymphocytic Leukemia;Clinic;CTLA4 gene;cytokine;Cytotoxic T-Lymphocytes;Data;demethylation;Development;Dioxygenases;Disease remission;DNA;Effectiveness;Enzymes;exhaust;exhaustion;Exhibits;Exposure to;FOXP3 gene;Functional disorder;Genetic Transcription;genome-wide;Goals;Hematologic Neoplasms;Human;human model;Immune;immune checkpoint blockade;Immune response;Immune system;Immunosuppression;Impairment;improved;Infiltration;inhibitor;innovation;Iron;Ligands;loss of function;Malignant Neoplasms;Memory;methyl group;Molecular;mouse model;Mus;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Oxidases;Oxidoreductase;Oxygen;Paper;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;Peptides;Phenotype;Population;prevent;Production;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;protein function;Protein translocation;receptor;Regulatory T-Lymphocyte;Rejuvenation;response;restraint;Role;Signal Pathway;Signal Transduction;Solid Neoplasm;Specific qualifier value;stem;success;T cell infiltration;T-Lymphocyte;TCF Transcription Factor;Testing;Time;Transplantation;tumor;Tumor Antigens;Tumor Escape;tumor microenvironment;Tumor Promotion;Tumor-associated macrophages;Up-Regulation;Virus Diseases

PROJECT_TITLE: Exploring the potential of TET inhibition in cancer immunotherapy

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The TP53 gene is mutated in about half of all cancers, with strong selection for missense mutations in the DNA binding domain. The resulting missense mutant protein can have different functions that affect various aspects of tumor formation and progression, such as the ability to metastasize, yet it has been extraordinarily difficult to sort out to what extent these functions are conserved between mutants. Systematically profiling the transcriptome of cells that harbor mutant p53 proteins, coupled with a detailed mechanistic characterization of representative mutants from each class, can potentially inform treatment strategies for cancer patients harboring tumors driven by specific TP53 alleles.

PI_NAMEs: KENNEDY, MARGARET  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Adopted;Affect;Alleles;base editing;Binding;biobank;Biological Assay;Biomedical Research;Cancer Patient;career;Cell Line;Cell Physiology;Cells;Cellular biology;ChIP-seq;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;Couples;Data;Development;disease model;DNA;DNA Binding Domain;Doxycycline;Ductal Epithelial Cell;Engineering;gain of function;Gene Chips;Gene Expression;Generations;Genetic Transcription;Goals;Guide RNA;Human;Impairment;In Vitro;in vivo;Individual;Invaded;Laboratories;Malignant Neoplasms;Mentors;metastatic process;Missense Mutation;Molecular;Molecular Biology;mouse model;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;novel strategies;Oncogenic;pancreatic cancer patients;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patients;Pattern;Phenotype;premalignant;programs;Property;Proteins;Publishing;Recurrence;Renilla;Reporting;Role;Sampling;single-cell RNA sequencing;skills;small hairpin RNA;Sorting;Testing;The Cancer Genome Atlas;Tissue-Specific Gene Expression;TP53 gene;Training;transcription factor;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment strategy;tumor;Tumor Promotion;Tumor Suppressor Genes;Tumor-Derived;tumorigenic;Variant;virtual;Work

PROJECT_TITLE: Understanding the divergent functions of mutant p53


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: RELEVANCE The proposed development of a new chemosensitivity assay technique has a direct relevance to the current practice of treating cancer. Directly testing a set of chemotherapy options on patients’ tumor cells by using the developed technique will enable us to better match patients with personalized treatment. The outcome of this project will ultimately help to make the promising strategy available to a much larger population of cancer patients than currently possible.

PI_NAMEs: LEE, JONGHWAN  (contact)

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: 3-Dimensional;Address;Adopted;attenuation;automated segmentation;Biological Assay;Biopsy;Cancer Patient;cancer therapy;cancer type;Cell Adhesion;Cell Culture Techniques;Cell Nucleus;Cell Survival;cell type;Cells;Chemicals;Chemosensitivity Assay;chemotherapy;clinical application;Clinical Trials;Combined Modality Therapy;Cultured Cells;Cytoskeleton;Data;Data Set;design;Development;Diffusion;Dimensions;Dose;Drug Combinations;drug discovery;drug testing;Drug usage;End Point Assay;Ethanol;Fractals;Future;Genomics;Guidelines;Hour;Image;image processing;Imaging technology;In Vitro;in vivo;Individual;individual patient;individualized medicine;innovation;Investigation;Label;longitudinal dataset;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Measurement;Measures;Medicine;Membrane;Metabolism;Methods;Microscopy;neoplastic cell;novel strategies;Oligomycins;Oncology;Optical Coherence Tomography;Optics;optimal treatments;Outcome;Paclitaxel;Pancreas;Patient Monitoring;patient population;Patients;personalized medicine;Pharmaceutical Preparations;Physicians;Pilot Projects;Population;precision medicine;Precision Medicine Initiative;precision oncology;prevent;Process;Proliferating;Research;response;Sampling;Sensitivity and Specificity;Series;Signal Transduction;Specificity;spheroids;statistics;Surface;Techniques;Technology;Testing;three dimensional cell culture;Time;Tissue Engineering;Tissues;Toxicity Tests;tumor;Tumor Cell Line;tumor microenvironment;Validation;Variant;Visit

PROJECT_TITLE: Label-Free, Longitudinal, Multi-Metric Viability Imaging of 3D Tissue Spheroid Array

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: Lay Summary The rapid ongoing development of novel imaging methods and tools is opening new directions for study in the field of cancer biology. The primary objective of the two-week course "Quantitative Imaging: From Acquisition to Analysis" is to train research scientists in the fundamental principles of quantitative light microscopy and computational analysis of biological images. The course offers lectures, discussion groups and extensive hands-on laboratory work using a wide range of conventional, advanced and emerging imaging techniques, and is designed to engage a multidisciplinary audience, including biologists, physicists, engineers and computer scientists. The short intensive nature of the course enables scientists to immerse in the concepts and techniques being taught and then rapidly disseminate what they have learned to others in their own laboratories.

PI_NAMEs: STEWART, DAVID J. (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: anti-cancer research;Area;Biochemistry;Biological;Cancer Biology;cancer cell;Cancer Research Project;career;Cells;Cellular biology;Computer Analysis;computer scientist;Computer software;Computers;Confocal Microscopy;Course Content;Data;Data Analyses;design;Detection;detector;Development;digital;digital imaging;Disadvantaged;Disease;education research;Educational process of instructing;Engineering;Ensure;Environment;Exercise;experience;experimental study;Faculty;Fluorescence;Fluorescence Recovery After Photobleaching;Fluorescence Resonance Energy Transfer;Foundations;gene product;graduate student;hands-on learning;Image;Image Analysis;Imaging Device;imaging modality;Imaging Techniques;instructor;International;Knowledge;Laboratories;laboratory experiment;Lasers;Learning;lectures;lens;Light;light microscopy;Lighting;Machine Learning;machine learning method;Malignant - descriptor;Malignant Neoplasms;Measurement;Methodology;Methods;Microscope;Microscopic;Microscopy;Mission;Modernization;Molecular Biology;multi-photon;multidisciplinary;multiphoton microscopy;Nature;neoplastic cell;novel;open source;Pathologic;photoactivation;Postdoctoral Fellow;Principal Investigator;Process;programs;Protein Analysis;quantitative imaging;Quantitative Microscopy;ratiometric;Reproducibility;Research;Research Personnel;Research Training;Sampling;Scanning;Schedule;Scientist;skills;Specimen;Structure;student training;Students;Subcellular structure;superresolution microscopy;System;Techniques;Technology;theories;Three-Dimensional Image;Time;Tissues;tool;Training;treatment strategy;ultra high resolution;Update;Work

PROJECT_TITLE: CSHL Quantitative Imaging: From Acquisition to Analysis Course

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Project Narrative: This Stage II Randomized Efficacy Trial will compare the effectiveness of a theoretically informed and culturally responsive brief motivational intervention to a non-adapted brief intervention among non-treatment seeking Latinxs admitted for medical treatment of an injury who engage in at risk drinking or were drinking at the time of their injury. The culturally informed brief motivational intervention (CI-BMI) increases autonomous motivation to engage in protective drinking behavior and reduce alcohol problems while addressing barriers to help seeking and facilitating treatment utilization. This project will address the alcohol related health disparities and treatment inequities among Latinx who are more likely to experience alcohol problems yet less likely to receive treatment in order to reduce the negative public health impact of alcohol.

PI_NAMEs: FIELD, CRAIG A (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acculturation;Address;Admission activity;Adopted;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol related problem;alcohol use disorder;alcohol-related injury;Alcohols;Behavior;behavior change;Behavioral Mechanisms;brief alcohol intervention;brief intervention;brief motivational intervention;community based participatory research;compare effectiveness;comparison intervention;Competence;Consumption;cultural values;Data Analyses;design;Dimensions;drinking;drinking behavior;Early identification;Effectiveness;efficacy testing;efficacy trial;Eligibility Determination;ethnic difference;experience;flexibility;General Population;Harm Reduction;Health Disparities Research;health disparity;help-seeking behavior;high risk drinking;Individual;injured;Injury;innovation;Intervention;Intoxication;Knowledge;Latinx;Lead;Mediator;Medical;Medical center;Meta-Analysis;Modification;Motivation;Outcome;Outcome Study;patient subsets;Patients;Population;primary outcome;Process;protective factors;Provider;psychologic;Public Health;Randomized;randomized trial;randomized, clinical trials;reduced alcohol use;Research;Research Support;response;Risk Factors;satisfaction;Science;secondary outcome;Self Determination;Stress;Testing;Texas;theories;Time;trauma care;trauma centers;treatment as usual;treatment disparity;treatment effect;Universities

PROJECT_TITLE: Stage II Efficacy Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities among Latinxs

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE Aggressive chronic lymphocytic leukemia (CLL) remains incurable even though with improved chemo regimens and targeted therapies. We have discovered that METTL3 is one of the most upregulated proteins in CLL, associated with poor prognosis, and regulates RNA splicing by translational control of splicing factors. We thus propose to understand the role of METTL3 on the onset and progression of CLL and examine if co- targeting METTL3 and RNA splicing regulator can be an effective therapeutic option for aggressive CLL.

PI_NAMEs: WANG, LILI  (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Address;Adoptive Transfer;adult leukemia;Automobile Driving;B-Lymphocytes;Biology;cancer therapy;Cell Line;Cell Proliferation;Cells;chemotherapy;Chemotherapy-Oncologic Procedure;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinical;Clinical Trials;Country;CRISPR screen;Data;Data Set;Defect;Deposition;design;Development;Disease;Disease Progression;Essential Genes;experimental study;Genes;Genetic Transcription;genome editing;genome-wide;Growth;Hematologic Neoplasms;Hematopoietic stem cells;improved;In Vitro;in vivo;independency;inhibitor;insight;Interleukins;Knock-out;Knockout Mice;Knowledge;Maintenance;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;Methyltransferase;Modeling;Modification;Molecular;mouse model;Mus;Mutation;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Oral;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmacologic Substance;Play;Post-Transcriptional Regulation;posttranscriptional;predictive marker;Prognosis;Prognostic Marker;Proliferating;protein complex;protein expression;Proteins;Proteome;Proteomics;Regimen;Regulation;Reporting;ribosome profiling;RNA;RNA Splicing;Role;Sampling;Site;small molecule inhibitor;Spliceosomes;targeted treatment;Technology;therapeutic target;therapeutically effective;Transcript;transcription factor;transcriptome;transcriptome sequencing;Translations;Treatment Protocols;Up-Regulation

PROJECT_TITLE: Define the oncogenic role of METTL3 in the pathogenesis of chronic lymphocytic leukemia

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The repair of DNA is vital to maintain the stability of our genetic material, as well as prevent the formation of mutations that can lead to the initiation and progression of malignancy. This proposal seeks to 1) gain insight into how the removal of ribonucleotides from the genome is regulated and 2) propose a novel method allowing the quantitative study of ribonucleotide incorporation in human cells. Completion of this work will shed light into how the enzyme RNase H2, and enzyme exhibiting frequent copy number loss in a Chronic Lymphocytic Leukemia, maintains genomic stability and prevents transformation to malignancy.

PI_NAMEs: BLOBEL, NICOLAS JOHANNES (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 13q;Alleles;Atlases;Automobile Driving;Basic Science;Biological Assay;Biology;Career Choice;Cell Line;Cell model;Cells;chromothripsis;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clonal Evolution;Data;Disease Progression;DNA Repair;DNA replication fork;DNA Sequence Rearrangement;Doctor of Philosophy;doctoral student;Enzymes;Excision;Excision Repair;Exhibits;exome;Future;Genes;Genetic;Genetic Materials;Genome;Genome Stability;Genomic Instability;Genomics;Germ Lines;Goals;Hematologist;Human;Human Cell Line;Hydrolysis;In Vitro;in vivo;insight;Institution;Laboratories;Light;Loss of Heterozygosity;Maintenance;Malignant Neoplasms;Measures;Mediating;Mentorship;Methods;micronucleus;Molecular;Mutagenesis;mutant;Mutate;Mutation;novel;Oncologist;Pathogenicity;Pathway interactions;Patients;Pattern;Peptides;Physicians;Poly(ADP-ribose) Polymerase Inhibitor;Prediction of Response to Therapy;Predisposition;prevent;Process;programs;protein purification;Proteins;Recombinants;recruit;Recurrence;Regulation;Relapse;repaired;replication stress;Research;response;Ribonuclease H;Ribonucleases;Ribonucleotides;RNA;RNase 2;Role;Running;Sampling;Scientist;Stimulator of Interferon Genes;Stress;termination factor;Tertiary Protein Structure;Testing;Therapeutic Intervention;Topoisomerase;tumor initiation;tumor progression;Tumor Suppressor Proteins;Universities;University Hospitals;Variant;whole genome;Work

PROJECT_TITLE: Mechanisms of genomic instability, tumor initiation and progression following the disruption of the RTF2-RNase H2 axis


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Networking and Information Technology R&D (NITRD);Precision Medicine;Regenerative Medicine

ORG_DEPT: DENTISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative In the United States, 30% of adults have oral disease associated tooth loss with this number expected to grow further over the next two decades. One reason for the poor oral health in the United States is the severe shortage of dental scientists, that are trained to translate basic science findings and technological advances to dental clinical practice. In this proposal, we are providing biomedical engineering research training to dentists and dental students, fostering a new generation of dental scientists who will lead the design and clinical translation of innovative dental treatments and prevention strategies, and ultimately advancing oral health care and practice. 1

PI_NAMEs: LU, HELEN H;WADHWA, SUNIL  (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Adult;Area;Big Data;Biocompatible Materials;bioimaging;Biomechanics;Biomedical Engineering;cellular engineering;Clinical;college;Computerized Medical Record;Country;craniofacial;deep learning;Degree program;Dental;Dental General Practice;Dental Instruments;Dental Research;Dental Schools;Dentistry;Dentists;Detection;Diagnostic;digital;Doctor of Philosophy;Education;engineered stem cells;Engineering;Ensure;Faculty;frontier;Funding;Generations;Goals;Grant;Health Occupations;Health Sciences;Image;Investments;Location;Medicine;Modeling;Mouth Diseases;multidisciplinary;next generation;Oral health;patient health information;Patients;personalized medicine;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Precision therapeutics;Productivity;Program Sustainability;programs;Provider;Puerto Rico;Regenerative engineering;Research;Research Personnel;Research Training;Schools;Science;Scientist;synthetic biology;Time;Tissue Engineering;Training;Training Programs;Underrepresented Populations;Universities

PROJECT_TITLE: Dental-Biomedical Engineering Scholars Training (D-BEST) Program


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Epithelial ovarian cancer (EOC) represents a high disease burden among African-American (AA) women who have poorer survival compared to European-American women. We identified inflammatory related exposures to be of particular importance in the risk of developing this disease among AA women. In this application, we propose to incorporate novel methodology integrating multi-level factors and inflammation related biomarkers to identify their role in ovarian cancer survival among AA women.

PI_NAMEs: LAWSON, ANDREW B.;SCHILDKRAUT, JOELLEN M. (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;advanced disease;Affect;African American;African American Women;Age;American;Analgesics;anti-cancer research;B-Lymphocytes;Biological Factors;Biological Markers;burden of illness;cancer diagnosis;cancer epidemiology;Cancer Etiology;Cancer Prognosis;cancer survival;Cancer Survivor;carcinogenesis;Case Study;Case/Control Studies;Censuses;Characteristics;Clinical;clinical effect;Cohort Studies;Collection;comorbidity;Complex;cytokine;Data;Data Collection;Data Sources;Databases;Diagnosis;Disease;Disparity;Enrollment;Ensure;Environment;Epidemiologic Factors;Epidemiology;epidemiology study;Epithelial ovarian cancer;European;Evaluation;experience;Exposure to;follow-up;Formalin;Funding;Geographic Locations;Goals;Health Services Accessibility;High Prevalence;immune checkpoint;Immunohistochemistry;improved;Incidence;Individual;individual patient;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Intervention;Length;Life Style;lifestyle factors;low socioeconomic status;Malignant neoplasm of ovary;Manuscripts;Measures;Medical Records;Methodology;Methods;mortality;mortality disparity;multidisciplinary;multilevel analysis;Neighborhoods;novel;Obesity;Outcome;Paraffin Embedding;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Physical environment;Play;Polymerase Chain Reaction;Population;Positioning Attribute;Prevention strategy;Prognosis;Prognostic Factor;Proteins;Psychosocial Factor;Publishing;Quality of life;Questionnaires;recruit;Reproductive History;Research Design;residence;Resources;Reverse Transcription;Risk;Risk Factors;Role;Sample Size;Site;Social Environment;social factors;sociodemographic factors;Specimen;survival disparity;Time;Tissues;Tumor Markers;Tumor Tissue;Tumor-associated macrophages;Tumor-Infiltrating Lymphocytes;United States;virtual;Woman;women's diagnosis;Women's mortality

PROJECT_TITLE: Ovarian Cancer Survival in African-American Women

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Progress in cancer therapy and prevention requires strong collaborative clinical research efforts. We plan to educate patient-oriented physician investigators to form a cohort of academic physicians expert at creating, implementing, and teaching cancer clinical research. These well-trained physicians will provide a critical link with physician-scientists and basic scientists in pursuit of innovative advances to improve the care of cancer patients.

PI_NAMEs: VERSCHRAEGEN, CLAIRE F. (contact);WESOLOWSKI, ROBERT

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Training Hematology and Oncology Fellows in Clinical Research


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Genetics;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Suicide;Violence Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE We will develop and validate models to predict suicide death, as distinct from suicide attempt, using electronic health records (EHR), demographics, environmental stresses, familial risks, and genetic differences. We will use 9,000 Utah suicides with longitudinal EHR data (>5,000 of these with molecular data growing to 10,000 by the end of the study), Utah population controls, collaborations with Mount Sinai Medical School and Vanderbilt University, and validation/replication with the large EHR and molecular data resources in the PsychEMERGE Consortium.

PI_NAMEs: COON, HILARY  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Accidents;Accounting;Address;Age;Anxiety;Area;Award;biobank;Cause of Death;Classification;Code;cohort;Cohort Studies;Collaborations;Collection;comparison group;Data;Data Element;data resource;demographics;deprivation;Development;Diagnostic;Discrimination;DNA;Documentation;early life stress;eHealth;Electronic Health Record;Elements;environmental stressor;Feeling suicidal;Future;Genetic;Genetic Risk;genome-wide;Genotype;Grouping;Hand;Healthcare;Healthcare Systems;high risk population;improved;Incidence;indexing;Individual;Intervention;Knowledge;large datasets;machine learning method;machine learning prediction;Major Depressive Disorder;Measures;Medical Examiners;medical schools;Mental disorders;model development;Modeling;Molecular;Natural Language Processing;Participant;Pharmaceutical Preparations;Phenotype;Physicians;polygenic risk score;Population;population based;Population Control;predictive modeling;Prevention;Resources;Risk;sample collection;Sampling;sex;socioeconomics;Substance Use Disorder;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Testing;Trauma;Universities;Utah;Validation;Work

PROJECT_TITLE: Prediction of suicide death using EHR and polygenic risk scores

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Health Services;Lung;Lung Cancer;Pediatric;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The objectives of this research are to improve the identification of children exposed to tobacco smoke, improve the delivery of parental tobacco control treatment in child healthcare offices, and in turn increase household cessation rates by testing the effectiveness of routinely screening children’s blood for cotinine, a biomarker of nicotine exposure, at the same time children are tested for lead. This innovative screening approach to detecting tobacco smoke exposure in children will provide cotinine biomarker results to pediatricians, send personalized cotinine feedback to parents about their child’s toxin exposure, and offer support to all household tobacco users to quit tobacco using trained tobacco cessation counselors to deliver Biomarker Informed Outreach (BIO). Data from this study will be used to measure how routinely screening children for cotinine and using BIO increases delivery of tobacco cessation assistance in child healthcare offices, improves household cessation rates, reduces tobacco smoke exposure in children, and if it is cost-effective compared to a tobacco control intervention that does not utilize routine cotinine measurement.

PI_NAMEs: WINICKOFF, JONATHAN P (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: 2 arm randomized control trial;Accounting;Aerosols;arm;Biochemical;Biological Markers;Blood;Blood specimen;Cessation of life;Child;Child health care;Childhood;Clinical;Clinical effectiveness;compare effectiveness;cost;cost effective;Cotinine;Counseling;Data;Disease;Documentation;effectiveness testing;Electronic Nicotine Delivery Systems;Enrollment;environmental tobacco smoke exposure;Exposure to;Family;Feedback;follow-up;Future;Health Benefit;health care delivery;Health system;Hemoglobin;Home;Household;improved;incremental cost;innovation;Institutionalization;Intervention;Lead;Life Expectancy;Link;Measurement;Measures;medically underserved;member;Methods;Morbidity - disease rate;mortality;next generation;Nicotine;nicotine exposure;nicotine replacement;Outcome;outreach;Parents;Patient Self-Report;pediatrician;Pregnancy Outcome;Prevalence;Primary Care;Professional counselor;Provider;provider adherence;quitline;Randomized;Research;Risk;routine screening;School-Age Population;screening;screening program;secondary analysis;Self Assessment;Services;Smoke;Smoker;smoking cessation;Support Groups;Surveys;System;Testing;Time;Tobacco;tobacco abstinence;tobacco cessation intervention;tobacco control;tobacco screening;Tobacco smoke;tobacco smoke exposure;Tobacco use;Tobacco Use Cessation;tobacco user;Toxin;Training;United States;uptake;vaping;Visit;Well Child Visits;Work;young adult

PROJECT_TITLE: Assessment of Biomarkers in Children to Help Parents Quit Tobacco

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Vascular disease is one of the greatest contributors to morbidity and mortality in Westernized cultures and world-wide with increasing incidence. The study of vascular disease requires the clinical insight of those professionals who care for these patients and possess a greater understanding of the impact of these conditions on patients to apply basic scientific findings to the care of such patients. The over goal of this training grant is to support the development of such clinician scientists as well as scientists with greater clinical insight into capable investigators who can further the innovation in vascular surgery.

PI_NAMEs: TZENG, EDITH  (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: Blood Vessels;Research Training;surgical research

PROJECT_TITLE: Vascular Surgery Research Training (VascTrain)


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Caregiving Research;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Radiation Oncology;Rare Diseases;Social Determinants of Health

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Narrative This multi-site collaboration will assess pediatric, adolescent, and young adult survivors (PAYAS) of cerebellar medulloblastoma (MB) and the unique contributions of (1) Environmental resources (e.g., area deprivation, material hardships, caregiver capacity, school quality), (2) clinical factors (e.g., MB molecular tumor type, treatment level, age) and (3) individual genetic diathesis (i.e., targeted single nucleotide polymorphism variants (SNPs) using gene and RNA sequencing association), as independent risk factors for cognitive impairment (CI). Further, we will create a multi-domain risk algorithm, using the most sensitive predictors of CI across the three domains, in order to create a multifactorial measure that best captures the biopsychosocial markers of CI outcomes in PAYAS of MB. Consistent with the STAR Act of 2018 and the Precision Medicine Initiative, this research will inform the development of risk- adapted chemoradiation treatment and preemptive interventions to prevent, mitigate and manage CI to optimize outcomes and improve overall quality of life in PAYAS of childhood cancer.

PI_NAMEs: KING, TRICIA Z. (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Adaptive Behaviors;Adolescent and Young Adult;Age;Algorithms;analysis pipeline;Area;biopsychosocial;Brain Neoplasms;candidate validation;Caregivers;caregiving;Caring;Cerebellum;Characteristics;chemoradiation;Childhood;Childhood Brain Neoplasm;childhood cancer survivor;Childhood Medulloblastomas;Clinical;Clinical Markers;Clinical Research;clinical risk;clinically relevant;Cognitive;cognitive ability;cohort;Collaborations;deprivation;design;Development;disability;Disease susceptibility;DNA Sequence Alteration;DNA sequencing;Dose;Drug Design;Early identification;Environmental Risk Factor;Epigenetic Process;Ethnic Origin;experience;family caregiving;folic acid metabolism;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic Transcription;genetic variant;Genotype;Health;health related quality of life;Heterogeneity;high risk;Impaired cognition;improved;indexing;Individual;Individual Differences;individualized medicine;Infrastructure;innovation;interest;Intervention;Late Effects;Life;Literature;Machine Learning;Malignant Neoplasms;Measures;Medulloblastoma;Methods;Modeling;Molecular;Molecular Genetics;molecular subtypes;Morbidity - disease rate;Mutation;NCI-Designated Cancer Center;Neighborhoods;neuroinflammation;Neuronal Plasticity;neurotoxic;neurotransmission;Outcome;Outcome Measure;outcome prediction;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;peer;Population;precision medicine;Precision Medicine Initiative;preemptive intervention;prevent;Prevention;preventive intervention;prophylactic;Proteins;Quality of life;Race;radiation risk;Readiness;Recording of previous events;recruit;Regimen;repaired;Research;Research Design;Resources;Risk;Risk Factors;RNA analysis;Schools;Severities;sex;SHH gene;Single Nucleotide Polymorphism;Site;socioeconomic adversity;standardize measure;Surveillance Modeling;Survivors;survivorship;tool;transcriptome sequencing;treatment response;tumor;Tumor Subtype;Variant;Weight

PROJECT_TITLE: Outcomes in AYA survivors of pediatric medulloblastoma.


NIH_SPENDING_CATS: Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE We have developed a novel vascularized three-dimensional (3D) human lung organoid and will use it to study how the human lung responds to infection and inflammation. We hope to define novel molecular pathways which regulate the resolution of inflammation and regeneration of the lung. The three dimensional human lung organoid will also allow us enable us to test new therapies for selected lung diseases such as inflammatory injury of the lung.

PI_NAMEs: KADUR LAKSHMINARASIM, PREETISH ;REHMAN, JALEES  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: 2019-nCoV;3-Dimensional;ACE2;Address;Affect;Affinity;Alveolar;alveolar epithelium;alveolar type II cell;Alveolus;Anastomosis - action;Blood Vessels;capsule;Cell Death;Cell Proliferation;cell type;Cells;Circulation;COVID-19 pandemic;Cues;Data;Development;disease model;Distal;drug efficacy;drug testing;Endothelial Cells;endothelial stem cell;Endothelium;Epithelial Cells;epithelial stem cell;Epithelium;Exclusion;gene regulatory network;Generations;Genes;Health;Homeostasis;Human;human disease;human induced pluripotent stem cells;human model;Implant;implantation;In Vitro;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;inflammatory lung disease;Injury;interest;Kidney;Lung;Lung Diseases;Lung infections;lung injury;lung maturation;lung microvascular endothelial cells;lung regeneration;Macrophage;Mediating;Metabolism;migration;Modeling;Molecular;monocyte;Morphogenesis;Mus;Natural regeneration;neutrophil;novel;novel therapeutics;Nutrient;Organoids;Pathology;Pathway interactions;Pattern;Peptides;Perfusion;Phenotype;Population;post SARS-CoV-2 infection;prevent;progenitor;Publishing;pulmonary function;receptor;Resolution;response;Role;Selection for Treatments;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cells;Structure;Structure of parenchyma of lung;Study models;System;Testing;Therapeutic;Type II Epithelial Receptor Cell;Up-Regulation;Vascular Endothelial Cell;Vascular Endothelium;Vascularization;WNT Signaling Pathway

PROJECT_TITLE: iPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial Cells

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This research focuses on acute myeloid leukemia (AML), which affects more than 10,000 Americans annually, the majority of who die of their disease within a short time. This research addresses the role of aberrant RAS signaling in relapsed/refractory AML and the efficacy of Mediator/RNA Pol II targeting as novel treatment strategy. The overall goal of this work is to establish new and effective strategies to treat relapsed/refractory AML.

PI_NAMEs: SMITH, CATHERINE CHOY (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affect;American;BCL2 gene;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Combined Modality Therapy;Dependence;Disease;DNA Polymerase II;efficacy evaluation;FLT3 gene;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Goals;improved;In Vitro;in vivo;Induction of Apoptosis;inhibitor;inhibitor therapy;Isocitrate Dehydrogenase;Leukemic Cell;Link;Malignant Neoplasms;Mediating;Mediator;Methods;Mitogen-Activated Protein Kinases;mutant;Mutate;Mutation;new therapeutic target;Newly Diagnosed;non-genetic;novel;novel strategies;novel therapeutics;Oncogenic;Pathway interactions;Patients;Pattern;Phosphorylation;Phosphotransferases;Pre-Clinical Model;programs;Recurrence;Refractory;Regulatory Element;Relapse;relapse patients;Research;Resistance;Resistance development;resistance mechanism;response;RNA;RNA Polymerase II;Role;Sampling;Signal Transduction;small molecule inhibitor;targeted treatment;Therapeutic;therapeutic target;therapeutically effective;therapy resistant;Time;Transcription Coactivator;Transcription Factor AP-1;Translating;treatment strategy;Tyrosine Kinase Inhibitor;Up-Regulation;Work

PROJECT_TITLE: RNA Polymerase II as a Therapeutic Target in Acute Myeloid Leukemia (AML) with RAS Signaling Activation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Recently we have discovered a new class of small molecule inhibitors against Cullin-RING E3 ubiquitin ligase- 4 (CRL4). This project seeks to further develop novel E3 CRL4 inhibitors and test their potential for anti-cancer therapy. To this end, we will: 1) improve CRL4 inhibitors by synthetic chemistry; 2) understand the molecular basis of how these compounds target CRL4; and 3) develop cell- and animal-based preclinical models to test the anti-cancer efficacy of CRL4 inhibitors against leukemia lines that are characterized by low CUL4 abundance.

PI_NAMEs: DEVITA, ROBERT J;PAN, ZHEN-QIANG  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Affinity;analog;Animals;anti-cancer;Apoptosis;Area;Binding;Biochemical;Biological Assay;C-terminal;cancer cell;Cancer Model;cancer therapy;CDT1 Gene;Cell division;Cell Line;Cells;Cellular Assay;cellular targeting;Chemical Structure;Chemicals;chemotherapy;Collaborations;Complex;CUL1 gene;CUL5 gene;cullin 4A;Cullin Proteins;cytotoxicity;Drug Kinetics;efficacy study;Enzymes;Exhibits;Family;FLT3 gene;high throughput screening;Human;improved;In Vitro;in vivo;inhibitor;interest;Laboratories;Lead;leukemia;leukemia treatment;Leukemic Cell;Ligand Binding;Ligands;Ligase;Malignant Neoplasms;Mediating;member;Modeling;Modification;Molecular;mouse model;Mus;Mutation;N-terminal;novel;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;pharmacophore;Physiological;Play;Polyubiquitination;Pre-Clinical Model;Property;Proteins;RBX1 gene;receptor;Reporting;response;Ring Finger Domain;Rodent;Role;scaffold;Signal Transduction;Small Interfering RNA;small molecule;small molecule inhibitor;Specificity;Structure-Activity Relationship;Study models;Survival Rate;Synthesis Chemistry;Testing;Therapeutic;Tissues;tumor;Tumor Suppression;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Variant;Xenograft procedure

PROJECT_TITLE: Modulate Cullin-RING E3 ubiquitin ligases by small molecule agents

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: OVERALL: NARRATIVE Cancer is a deadly disease for which there is no panacea but requires a multi-pronged approach to improve the outcomes of our patients. To that end, the Herbert Irving Comprehensive Cancer Center at Columbia University Irving Medical Center/New York Presbyterian Hospital is dedicated to the vision and mission of reducing the cancer burden in our catchment area. The HICCC spans basic, translational, clinical and population research that is supported by shared resources, community outreach and engagement, training and education, and strategic investments, all converging on cancer screening, surveillance, early detection, prognosis, therapy, survivorship and palliation.

PI_NAMEs: RUSTGI, ANIL K (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Achievement;anti-cancer research;Appointment;Articulation;authority;Basic Science;Cancer Burden;cancer care;Cancer Care Facilities;Cancer Center;Cancer Center Support Grant;cancer education;cancer genomics;cancer research center director;Cancer Science;career;career development;Catchment Area;Clinical;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Outreach;Continuity of Patient Care;Dedications;Disease;diversity and inclusion;Dryness;Early Diagnosis;Education and Outreach;education research;epigenomics;Faculty;Faculty Recruitment;Family;Fostering;Funding;Gifts;Grant;Herbert Irving Comprehensive Cancer Center;Hospitals;improved outcome;Infrastructure;innovation;Institution;inter-institutional;Intervention;investigator-initiated trial;Investments;Journals;laboratory facility;Laboratory Research;Leadership;Malignant Neoplasms;Medical center;member;Mentors;Mission;National Cancer Institute;New York;novel;Oncology;palliation;panacea;Patient Care;Patients;Peer Review;Population Research;Population Sciences;precision oncology;Presbyterian Church;Prevention;Prognosis;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;Role;Schools;Science;Screening for cancer;Services;Structure;survivorship;Systems Biology;Training;Training and Education;Translational Research;Translations;Trust;Tumor Biology;tumor microenvironment;Underrepresented Minority;United States National Institutes of Health;Universities;Vision

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Address;anti-cancer research;base;Budgets;Cancer Center;Cancer Center Support Grant;career;Catchment Area;Clinical Data;Clinical Protocols;Clinical Trials;Collaborations;Communication;Communities;community engagement;Community Outreach;design;Development;Documentation;Ensure;Environment;Equipment;Fostering;Foundations;Funding;Funding Mechanisms;Goals;Grant;Guidelines;Herbert Irving Comprehensive Cancer Center;Hospitals;Human Resources;Industry;innovation;Institution;Leadership;Logistics;meetings;member;Mission;NCI Center for Cancer Research;New York;Office Management;operation;Presbyterian Church;Process;programs;Reporting;Research;research and development;Research Infrastructure;Research Support;Resource Sharing;Resources;Services;symposium;Universities

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

PI_NAMEs: CHUNG, WENDY K (contact)

PROJECT_TERMS: Academy;Accreditation;anti-cancer research;Cancer Center Support Grant;cancer genetics;cancer genomics;career;career development;Catchment Area;Clinical;Clinical and Translational Science Awards;clinical practice;Collaborations;Communities;Community Health Education;Community Outreach;Competence;Comprehensive Cancer Center;Continuing Education;Critical Thinking;Cytogenetics;Data;Dental;Dental Students;Discipline;Discipline of Nursing;Doctor of Philosophy;Education;education research;education resources;Educational process of instructing;Educational workshop;Effectiveness;Engineering;Ensure;Environment;epigenomics;Ethnic Origin;Exposure to;Faculty;Family;Fellowship Program;Future;Genetic Counseling;Genome;Genomics;Goals;Grant;health disparity;Health Professional;Herbert Irving Comprehensive Cancer Center;high school;improved;innovation;Institution;interdisciplinary approach;Investments;Journals;Laws;Lead;Leadership;Malignant Neoplasms;Medical;Medical center;Medical Genetics;Medical Students;Medicine;member;Mentors;Mentorship;minority trainee;Molecular;Monitor;Names;New York;New York City;next generation;novel;Nursing Students;Oral health;Output;Patients;Pediatrics;Play;Population;Population Sciences;Precision Health;precision medicine;Precision Medicine Initiative;prevent;Productivity;professional students;professor;Program Development;programs;Public Health Schools;Race;Recording of previous events;recruit;Research;Research Personnel;Resources;Role;Schools;Scientist;skills;socioeconomics;Source;Strategic Planning;symposium;synergism;TNFSF15 gene;Training;Training and Education;training opportunity;Training Programs;Translating;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;web site;Work;Writing

PROJECT_TITLE: Cancer Research Career Enhancement


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

PHR: Project Narrative Despite social deficits being core features of autism spectrum disorder (ASD) and contributing to relationship difficulties and low employment rates, their neurobiological underpinnings are poorly understood. The goal of this study is to gain new knowledge about the brain mechanisms underlying social deficits in autism using computational modeling, novel brain imaging tools, and interactive experimental tasks that simulate dynamic social interactions. In contributing to our understanding of the brain basis of ASD, this study may unveil new directions for intervention.

PI_NAMEs: FOSS-FEIG, JENNIFER ;GU, XIAOSI ;SCHILLER, DANIELA  (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Affect;Anterior;autism spectrum disorder;autism symptoms;Biology;Brain;Brain imaging;Brain region;Caregivers;Child;cingulate cortex;Clinical;clinical predictors;Communities;Complex;computational neuroscience;computer framework;Computer Models;Corpus striatum structure;cost;Data;Development;Dimensions;effective intervention;Employment;Environment;Face;face perception;Functional impairment;Functional Magnetic Resonance Imaging;functional outcomes;geometric structure;Goals;Heterogeneity;Hippocampal Formation;Hippocampus;Human;Image;Imaging Device;Impairment;improved;indexing;Individual;individuals with autism spectrum disorder;Inferior;innovation;insight;Insula of Reil;Intervention;Investments;Knowledge;Learning;Length;Location;Machine Learning;Maps;Measures;Modeling;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuroimaging;Neurosciences Research;novel;Outcome;Paper;Parietal Lobe;Participant;patient engagement;Phenotype;Process;Psychiatry;Publishing;Quality of life;rapid growth;Reporting;Research;Resolution;response;Signal Transduction;social;Social Adjustment;Social Behavior;social communication;Social Controls;social deficits;Social Environment;Social Functioning;Social Interaction;social learning;social neuroscience;social norm;Social Processes;social relationships;social skills;social space;Social Values;Structure;supervised learning;Symptoms;System;Testing;Thinking;Time;tool;United States;unsupervised learning;vector;Ventral Striatum;virtual;virtual reality;Work

PROJECT_TITLE: Neurocomputational mechanisms of proactive social behavior deficits in autism spectrum disorder

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative/Public Health Relevance Statement Psychosocial interventions have been shown to be effective for the mainstream population of breast cancer survivors, but few psychosocial interventions have been successfully designed for ethnic groups of color. This proposed study is a randomized controlled trial to assess the impact of a culturally based brief writing intervention among Chinese immigrant breast cancer survivors, an underserved and understudied population. The study will help to reduce or eliminate the unnecessary emotional and physical health disparities in cancer care among Asian American breast cancer survivors and potentially other ethnic groups of color as well.

PI_NAMEs: LU, QIAN  (contact)

PROGRAM_OFFICER_NAME: CHOU, WEN-YING

PROJECT_TERMS: Acculturation;Address;Adopted;Aftercare;alpha-amylase;American;Asian;Asian Americans;Attention;Biological Markers;breast cancer diagnosis;Breast Cancer survivor;brief intervention;California;cancer care;cancer health disparity;Cancer Survivor;cancer therapy;Chinese;Chinese American;Chinese population;cognitive process;Color;Communities;community organizations;cultural competence;cultural values;design;Diagnosis;effective intervention;Emotional;Emotions;Equipment;Ethnic Population;Evidence based program;experience;expressive writing;follow-up;Fright;Goals;healing;Health;Health Benefit;Health Disparities Research;health disparity;Health Professional;Health Promotion;Human Resources;Hydrocortisone;Immigrant;improved;Incidence;Informal Social Control;innovation;internalized stigma;Intervention;Language;Loneliness;Mainstreaming;Malignant Breast Neoplasm;Malignant Neoplasms;medical appointment;Medical Records;Mental Health;Mental Health Services;Methods;Minority;minority communities;Morbidity - disease rate;New York;Not Hispanic or Latino;Outcome;Participant;Patient Self-Report;Patients;people of color;perceived stress;physical conditioning;Population;Posttraumatic growth;primary outcome;psychologic;psychosocial;public health relevance;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Recovery Support;recruit;Reduce health disparities;Research;Resource-limited setting;Salivary;secondary outcome;social stigma;Stress;stress management;stress reduction;Stressful Event;Subgroup;Testing;Texas;theories;Thinking;traumatic event;underserved community;Underserved Population;United States;Writing

PROJECT_TITLE: Writing to Heal: A Culturally Based Brief Expressive Writing Intervention for Chinese Immigrant Breast Cancer Survivors

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


PI_NAMEs: SANTELLA, REGINA M (contact)

PROJECT_TERMS: adduct;Aliquot;Applications Grants;Archives;assay development;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker evaluation;biomarker panel;Blood;blood fractionation;Body Fluids;Breast Cancer Risk Factor;British;cancer biomarkers;Cancer Center Support Grant;cancer epidemiology;cancer risk;Candidate Disease Gene;Carcinogen exposure;Carcinogens;Cells;Clinical;Clinical Research;Code;Collaborations;Collection;Consultations;cost effective;Custom;Data;Data Analyses;Databases;DNA;DNA analysis;DNA Methylation;DNA methylation profiling;DNA Repair;Doctor of Philosophy;Education;Environmental Exposure;Environmental Health;Environmental Impact;Enzyme-Linked Immunosorbent Assay;epidemiology study;Equipment and supply inventories;Erythrocytes;experience;Experimental Designs;Farm;Freezing;Funding;Genes;Genetic Predisposition to Disease;Goals;Grant;granulocyte;Herbert Irving Comprehensive Cancer Center;Human;Human Resources;Individual;Joints;Journals;Leukocytes;Logistics;Maintenance;malignant mouth neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;member;Methods;MicroRNAs;Microscope;miRNA expression profiling;Molecular Epidemiology;Molecular Epidemiology of Cancer;molecular pathology;Mononuclear;mRNA Expression;National Institute of Environmental Health Sciences;Needs Assessment;Nucleic Acids;Online Systems;Paper;Peer Review;Phenotype;Plasma;Preparation;Prevention;Procedures;Process;Prognosis;programs;prospective;Protein Analysis;protein biomarkers;Proteins;Protocols documentation;Publications;pyrosequencing;Quality Control;Recruitment Activity;repository;Reproducibility;Research;Research Design;Research Project Grants;research study;Research Support;Resource Sharing;Resources;Risk Factors;RNA;sample collection;Sampling;Sampling Studies;Secure;Serum;Services;Shipping;Slide;SNP genotyping;Standardization;System;Techniques;Testing;Tissues;Training;Training and Education;treatment response;tumor;United States National Institutes of Health;Vial device

PROJECT_TITLE: Biomarkers Shared Resource


NIH_SPENDING_CATS: Anxiety Disorders;Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Rare Diseases;Serious Mental Illness

ORG_NAME: YALE UNIVERSITY

PHR: NARRATIVE Pediatric acute-onset neuropsychiatric syndrome (PANS), characterized by the sudden onset of symptoms of obsessive-compulsive disorder (OCD), food restriction, and attendant neurological and psychiatric signs, is often severe and has remained enigmatic. PANS is often associated with recent infection, and a neuro-immune pathophysiology has been hypothesized; we have recently found that children with PANDAS, a subset of PANS associated with recent Streptococcal infection, have antibodies targeting a specific interneuron population within the basal ganglia circuitry, the cholinergic interneurons. Here we apply state-of-the-art methodologies across a large cohort of patients identify the specific molecules recognized by these antibodies, to test whether this finding extends to other forms of PANS, and to isolate, for the first time, the specific pathogenic antibodies in individual children with PANS and PANDAS.

PI_NAMEs: PITTENGER, CHRISTOPHER JOHN (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Affect;Antibodies;Antibody Formation;Antigens;Anxiety;Autoantibodies;Autoantibody binding;Autoimmunity;Autopsy;B-Lymphocytes;Basal Ganglia;Behavior;Behavioral;beta catenin;Binding;Biological Assay;Brain;brain tissue;candidate identification;candidate validation;Characteristics;Child;Childhood;cholinergic;cholinergic neuron;Chorea;Clinic;Clinical;clinical subtypes;cohort;Coin;comorbidity;Consensus;Corpus striatum structure;Country;Cross Reactions;Data;Development;diagnostic tool;Discrimination;disease classification;Enzyme-Linked Immunosorbent Assay;Epitopes;Etiology;Exhibits;food restriction;Functional disorder;Gilles de la Tourette syndrome;Hand;Human;Immune;immune function;Immunofluorescence Immunologic;Immunoglobulin G;immunomodulatory therapies;immunoreaction;In Vitro;Individual;Infection;Inflammation;innovation;Interneurons;Lead;Literature;Medial;medical specialties;Membrane;Methodology;Modeling;Molecular Conformation;Molecular Target;monoclonal antibody production;Morbidity - disease rate;Mus;neural;Neuroimmune;neuroinflammation;Neurologic;Neurons;Noise;novel;novel diagnostics;novel strategies;Obsessive-Compulsive Disorder;pathogenic autoantibodies;Pathogenicity;Pathology;Patients;Pattern;Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus Infections;Peripheral Blood Mononuclear Cell;Population;post SARS-CoV-2 infection;Predisposition;Process;Production;Prosencephalon;Proteins;putamen;Recombinants;repetitive behavior;Sampling;screening;Separation Anxiety;Serum;Signal Transduction;Streptococcal Infections;Streptococcus;Surface;Sydenham Chorea;symposium;symptomatic improvement;symptomatology;Symptoms;Syndrome;Techniques;Testing;Time;Tissues;treatment center;urinary;Work;Yeasts

PROJECT_TITLE: Anti-interneuron antibodies in rapid-onset pediatric OCD: clinical generalization and target identification

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PI_NAMEs: FLORATOS, ARIS  (contact)

PROJECT_TERMS: Adopted;Adoption;analytical method;analytical tool;anti-cancer research;Applications Grants;Basic Cancer Research;Bioinformatics;Biological Markers;biological research;biomedical informatics;Biomedical Research;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer education;Cancer Etiology;Cells;Collection;Communities;Complex;Computational Biology;computational pipelines;computer cluster;computer infrastructure;computerized tools;computing resources;Consult;cost;cost effective;Data;Data Analyses;data repository;Data Set;Data Storage and Retrieval;Databases;Dedications;Development;Disease Progression;Doctor of Philosophy;drug mechanism;Ensure;Environment;experience;Experimental Designs;Faculty;Flow Cytometry;Funding;gene regulatory network;genomic data;Genomics;Goals;Herbert Irving Comprehensive Cancer Center;High Performance Computing;high throughput technology;Human Resources;Individual;Informatics;informatics shared resource;informatics tool;Infrastructure;insight;Investigation;Journals;Knowledge;Laboratories;lipidomics;Literature;Maintenance;Malignant Neoplasms;Manuscripts;Mediating;member;Memory;metabolomics;Methodology;Methods;Molecular;multidimensional data;Nature;NCI Center for Cancer Research;novel;operation;Paper;petabyte;Phenotype;Play;Precision cancer therapy;Process;programs;Proteomics;Publications;repository;Research;Research Peer Review;Research Personnel;Research Project Grants;Resources;Sample Size;Services;Signal Transduction;statistics;stem cells;success;System;Systems Biology;Technology;technology platform;terabyte;Therapeutic;tool;Training;Training and Education;transcriptomics;translational cancer research;Translational Research;treatment response;United States National Institutes of Health;Universities;Update;Validation;Work

PROJECT_TITLE: Biomedical Informatics Shared Resource


PI_NAMEs: HU, JIANHUA  (contact)

PROJECT_TERMS: Address;advanced analytics;analytical tool;anti-cancer research;Applications Grants;Biometry;Biostatistics Shared Resource;Brain;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Clinical;Clinical Investigator;clinical trial protocol;Clinical Trials;Clinical Trials Design;community center;Complex;computer infrastructure;Consultations;cost;cost effective;cost effectiveness;Data;Data Analyses;data handling;design;Development;disease heterogeneity;disease model;Doctor of Philosophy;Doctor's Degree;Education;education resources;Ensure;experience;experimental study;Funding;Futility;Genomics;Goals;Grant;Graph;Herbert Irving Comprehensive Cancer Center;high dimensionality;high standard;human study;Image;Infrastructure;innovation;Malignant neoplasm of esophagus;Malignant Neoplasms;Manuscripts;Measures;Medical;member;Methodology;Monitor;NCI Center for Cancer Research;Needs Assessment;non-traditional data;Outcome;Pancreas;personalized medicine;Population;power analysis;Preparation;Procedures;professor;programs;prospective;Proteomics;protocol development;Protocols documentation;Publications;Randomized;randomized, clinical trials;recruit;Regression Analysis;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Sample Size;Scheme;Scientist;Services;Specific qualifier value;Standardization;Statistical Data Interpretation;statistical service;statistics;Stratification;Structure;Therapeutic;Time;tool;Toxic effect;Training;Training and Education

PROJECT_TITLE: Cancer Biostatistics Shared Resource


NIH_SPENDING_CATS: Cancer;Kidney Disease;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Clear cell renal cell carcinoma (ccRCC) has a poor prognosis especially once it becomes metastatic and is in urgent need of novel treatment strategies. Branched-chain amino acid (BCAA) catabolism is reduced in ccRCC and decreased expression of BCAA enzymes correlates with poorer overall patient survival. We propose here that reduced BCAA catabolism promotes ccRCC cell growth and tumorigenesis and will test this hypothesis with a range of in vitro experiments and mouse models to understand in depth how modulation of BCAA metabolism regulates ccRCC tumorigenesis.

PI_NAMEs: COFFEY, NATHAN JACKSON (contact)

PROJECT_TERMS: Accounting;Acetyl Coenzyme A;Acetylcysteine;Acute;Affect;Albumins;amino acid metabolism;Animals;Antioxidants;Apoptosis;Appearance;Blood Urea Nitrogen;Branched-Chain Amino Acids;branched-chain-amino-acid transaminase;cancer type;Catabolism;cell growth;Cell Line;Cell Physiology;Cell Proliferation;Cells;Citric Acid Cycle;Clear Cell;Clear cell renal cell carcinoma;combat;Complex;Creatinine;Cytoplasm;Data;Dietary intake;Disease;Enzymes;Epithelial Cells;Essential Amino Acids;Etiology;Experimental Models;fatty acid oxidation;Fatty Acids;gain of function;Genes;Genetic;Genetically Engineered Mouse;Glycogen;Histologic;Histology;Human;Impairment;Implant;In Vitro;in vivo;Incidence;Isoleucine;Isotopes;Keto Acids;Kidney;knock-down;Leucine;Link;Lipid Peroxidation;Lipids;loss of function;Malignant Epithelial Cell;Malignant Neoplasms;Measurement;Measures;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Molecular Analysis;Monitor;mouse model;Multienzyme Complexes;Mus;new therapeutic target;NIH-III Mouse;North America;novel;novel therapeutics;Nude Mice;Obesity;Oxidative Phosphorylation;Oxidoreductase;Oxygen Consumption;Pathway interactions;Patients;peroxidation;pharmacologic;Phosphotransferases;Predisposition;Production;Prognosis;Proliferating;protein complex;Reaction;Reactive Oxygen Species;Renal Carcinoma;renal epithelium;Renal function;Resected;Respiration;Risk Factors;Role;Serum;small hairpin RNA;succinyl-coenzyme A;Survival Rate;Tamoxifen;Testing;Tissues;treatment strategy;tumor;tumor growth;Tumor Promotion;Tumor Volume;tumorigenesis;Valine;Work;Xenograft procedure

PROJECT_TITLE: Investigating the Role of Reduced Branched-Chain Amino Acid Catabolism in Clear Cell Renal Cell Carcinoma


PI_NAMEs: PON, LIZA A (contact)

PROJECT_TERMS: 3-Dimensional;Address;anti-cancer research;Biological;Biophysics;Cancer Biology;cancer cell;Cancer Center Support Grant;Cancer Model;Cancer Research Project;cell fixing;Cells;Cellular biology;cellular imaging;Color;community center;Computer software;Confocal Microscopy;Consultations;cost effectiveness;Data;data acquisition;Data Analyses;data visualization;Doctor of Philosophy;Doctor's Degree;Education;empowerment;Ensure;Equipment;Evaluation;experience;Experimental Designs;Fluorescence;fluorescence imaging;Funding;Generations;Goals;Grant;Herbert Irving Comprehensive Cancer Center;high resolution imaging;Histology;Hour;Human Resources;Image;image processing;Imaging Device;imaging modality;imaging platform;imaging system;Imaging Techniques;Imaging technology;insight;instrument;instrumentation;irradiation;Journals;laser capture microdissection;Laser Scanning Confocal Microscopy;Light;Lighting;live cell imaging;member;Microscope;Microscopy;Nature;Needs Assessment;new technology;novel;novel imaging technology;operation;Optics;Peer Review;Policies;programs;prospective;Proteins;Publications;Qualifying;Reader;reconstruction;Reporting;Reproducibility;Research;Research Project Grants;Research Support;Resource Sharing;Resources;response;Sampling;Scanning;Scientist;second harmonic;Secure;service providers;Services;Site;Source;spectrograph;Structure;superresolution microscopy;Surveys;System;Techniques;Technology;technology development;technology validation;three dimensional structure;Time;Tissues;tool;Training;Training and Education;two-photon;ultra high resolution;United States National Institutes of Health;Update;Visualization

PROJECT_TITLE: Confocal and Specialized Microscopy Shared Resource


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: CREW, KATHERINE D (contact)

PROJECT_TERMS: Adult;Agreement;Ancillary Study;anti-cancer research;Award;Back;bilingualism;biobank;Biological Markers;Blood;Blood specimen;Breast;Cancer Center Support Grant;cancer epidemiology;Cancer Patient;cancer prevention;cancer risk;Chest;CLIA certified;Clinic;Clinical;Clinical Data;Clinical Management;clinically actionable;Communities;community center;computerized data processing;Consent;cost;cost effective;Data;Data Linkages;data warehouse;Databases;Dedications;Dermatology;Development;Doctor of Philosophy;early onset;electronic health data;Electronic Health Record;Eligibility Determination;Enrollment;epidemiologic data;ethnic diversity;Formalin;Fostering;Freezing;Funding;Future;gastrointestinal;Genitourinary system;Goals;Grant;Hematology;Herbert Irving Comprehensive Cancer Center;Hospitals;Individual;Information Management;Infrastructure;infrastructure development;innovation;insight;Journals;Laboratories;lifestyle factors;Link;Maintenance;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical center;Melanoma;member;Molecular Classification of Tumors;molecular marker;molecular pathology;NCI Center for Cancer Research;neuro-oncology;New York;novel;Olives - dietary;Paper;Paraffin Embedding;Participant;participant enrollment;Pathology;patient derived xenograft model;Patient Recruitments;patient screening;Patients;Peer Review;Population;Population Heterogeneity;Presbyterian Church;Prevention;Prevention Research;Process;Prospective cohort;Protocols documentation;Publications;Publishing;Qualifying;Questionnaires;racial diversity;Recontacts;recruit;Registries;Reporting;Research;Research Project Grants;Research Support;Residual state;Resource Sharing;Resources;Retrospective cohort;Review Committee;Saliva;saliva sample;Sarcoma;screening;Secure;Services;shared database;Solid Neoplasm;Specimen;Standardization;Surveys;Thyroid Gland;Tissue Embedding;Tissue Sample;Tissues;Training and Education;Translational Research;tumor;tumor registry;Tumor Tissue;Universities;Urine;web platform;Work

PROJECT_TITLE: DataBase Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer

PI_NAMEs: CREUSOT, REMI J (contact)

PROJECT_TERMS: anti-cancer research;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;Cell Separation;Cell surface;Cells;Color;Complex;complex data;Computer software;Computers and Advanced Instrumentation;Conceptions;Consultations;cost effective;cost effectiveness;Data;data acquisition;Data Analyses;Dedications;density;design;detector;Development;Doctor of Philosophy;Education;empowerment;Equipment;Event;experience;Flow Cytometry;Flow Cytometry Shared Resource;Funding;Goals;Hematopoietic;Herbert Irving Comprehensive Cancer Center;high dimensionality;high standard;high throughput screening;Hour;Human Resources;Immune;Immunology;indexing;Infiltration;Infrastructure;insight;instrument;instrumentation;Intracellular Signaling Proteins;Journals;Lasers;Leadership;leukemia/lymphoma;Lymphoid Cell;Maintenance;Malignant Neoplasms;Manuscripts;member;Metabolic Marker;multidimensional data;Myeloid Cells;Nature;Needs Assessment;neoplastic cell;new technology;novel;Peer Review;Population;Preparation;programs;prospective;Protocols documentation;Publications;Qualifying;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Sampling;Scientist;Secure;service providers;Services;Solid;Sorting;Speed;Stains;stem cells;success;Techniques;Technology;technology development;technology validation;Time;tool;Training;Training and Education;transcription factor;translational immunology;Trees;tumor;tumor immunology;United States National Institutes of Health;Walking

PROJECT_TITLE: Flow Cytometry Shared Resource


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This grant supports the training of scientists working in a broad spectrum of oral health research fields that range from basic and translational biological research, to clinical, public health and sociobehavioral research. We provide trainees with strong research skills in their specific disciplines as well as with skills to work on multi- and interdisciplinary research teams to facilitate the translation of research findings into clinical and community-based applications that improve the public's health.

PI_NAMEs: CHI, DONALD LESLIE (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Appointment;Area;Authorship;Basic Science;Behavioral;Biometry;career;career development;Clinical;craniofacial;craniofacial structure;Dental;Dentists;Development;Development Plans;Discipline;Disease;Doctor of Philosophy;Doctor's Degree;Eligibility Determination;Engineering;Epidemiology;experience;Funding;genetic approach;Goals;Grant;Health;Health Sciences;Health system;Human Resources;improved;Individual;Interdisciplinary Study;interest;member;Mentors;Molecular;National Institute of Dental and Craniofacial Research;Oral;Oral health;Outcome;population health;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process Measure;programs;Public Health;Public Health Schools;Publications;Research;Research Training;School Dentistry;school health;Scientist;skills;stem cell biology;tissue regeneration;Training;Training Programs;Translating;Translational Research;Universities;Washington;Work

PROJECT_TITLE: Comprehensive Training in Inter-Disciplinary Oral Health Research


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PI_NAMEs: QUE, JIANWEN  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Appointment;Area;Bacterial Artificial Chromosomes;Biotinylation;blastocyst;Breeding;cancer cell;Cancer Center Support Grant;Cancer Model;Chimeric Proteins;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;conditional knockout;Consultations;cost;cost effectiveness;CRISPR/Cas technology;Cytoplasm;Data;design;Development;DNA Double Strand Break;Doctor of Philosophy;Doctor's Degree;Education;egg;Electroporation;Embryo;embryo cell;embryonic stem cell;empowerment;Engineering;Ensure;ES Cell Line;Exons;experience;Funding;G2 Phase;Gene Modified;Gene Targeting;gene-editing approach;Generations;Genes;Genetic;genetic manipulation;Genetic Techniques;genome editing;Genotype;Goals;Herbert Irving Comprehensive Cancer Center;homologous recombination;in vivo;Injections;insertion/deletion mutation;insight;investigator training;Journals;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Leadership;Malignant Neoplasms;Mediating;Medical center;Medicine;member;Molecular;Molecular Biology Techniques;Molecular Genetics;monomer;Mouse Embryonic Stem Cells;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutation;Nature;NCI Center for Cancer Research;Needs Assessment;new technology;novel;Nucleotides;Oncogenes;Paper;Peer Review;Performance;Phenotype;Point Mutation;Policies;Process;Production;programs;prospective;Protocols documentation;Provider;Publications;Quality Control;Quarantine;Recombinants;Recording of previous events;Reporter;Reproducibility;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Ribonucleoproteins;Services;Single-Stranded DNA;Site;Source;stem;Streptavidin;Surveys;Technical Expertise;Techniques;Technology;technology development;Testing;tool;Training;Training and Education;Transgenes;Transgenic Mice;Transgenic Organisms;tumor;United States National Institutes of Health;Universities;vector;Walking;zygote

PROJECT_TITLE: Genetically Modified Mouse Models


PI_NAMEs: COURONNE, OLIVIER  (contact)

PROJECT_TERMS: active duty;anti-cancer research;ATAC-seq;Biomedical Research;Cancer Center Support Grant;cancer genomics;career;cDNA Library;Cells;chemical genetics;Chemicals;ChIP-seq;Complex;Computer software;Consultations;cost effective;cost effectiveness;CRISPR screen;Data;Data Analyses;Dedications;Development;DNA;DNA analysis;DNA sequencing;Doctor of Philosophy;Drug Targeting;Educational workshop;Equipment;exome;experience;Experimental Designs;forward genetics;Funding;Genetic;Genetic Screening;Genome;genome-wide;Genomics;Grant;Herbert Irving Comprehensive Cancer Center;high throughput screening;Hour;Human Resources;Immune;innovation;insight;instrument;instrumentation;Journals;Libraries;loss of function;Malignant Neoplasms;Medicine;member;Microscopy;Mission;Nature;NCI Center for Cancer Research;Needs Assessment;new technology;next generation;next generation sequencing;novel;operation;Peer Review;personalized cancer therapy;programs;prospective;Publications;Qualifying;Reproducibility;Research;Research Personnel;Research Support;Resource Sharing;Resources;response;RNA;RNA Interference;Robotics;screening;screening services;Services;single cell analysis;single cell ATAC-seq;single cell sequencing;single-cell RNA sequencing;small molecule libraries;System;Systems Biology;Techniques;Technology;technology development;technology validation;Time;Training;Training and Education;transcriptome sequencing;transcriptomics;tumor;tumor heterogeneity;United States National Institutes of Health;whole genome

PROJECT_TITLE: Genomics and High Throughput Screening


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE This investigation is focused on identifying polygenic and metabolomic factors that contribute to prostate cancer risk in multiethnic men. Results from this research are expected to substantially contribute to our knowledge of the underlying mechanisms that contribute to prostate cancer risk and health disparities and improve predictive models of prostate cancer across ethnic and racial populations. This would improve our ability to detect high risk individuals who would benefit from earlier or more intensive screening and provide novel biological mechanisms to target for preventative measures, likely reducing prostate cancer mortality and the number of indolent cases treated unnecessarily.

PI_NAMEs: DARST, BURCU FRANCES (contact)

PROJECT_TERMS: African;African American;African ancestry;Age;Age of Onset;Aging;Algorithms;American;anti-cancer research;Asian;Biological;cancer epidemiology;Cancer Etiology;cancer health disparity;Cessation of life;cohort;Complex;Data;Death Rate;Disease;Disparity;Environmental Risk Factor;Ethnic Origin;Ethnic Population;European;Exclusion;flexibility;Genetic;genetic epidemiology;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Goals;Health;health disparity;Heritability;high risk;high risk population;improved;Incidence;Individual;Indolent;insight;Investigation;Latino;loss of function;Malignant neoplasm of prostate;Mediating;Mediation;men;Mentors;Meta-Analysis;Metabolic;metabolome;metabolomics;Methods;Modeling;mortality;multi-ethnic;multiple omics;novel;Outcome;Phase;polygenic risk score;Population;predictive modeling;Predictive Value;Preventive measure;prostate cancer model;prostate cancer progression;prostate cancer risk;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;racial population;Research;Risk;Risk Assessment;risk variant;Sampling;screening;Screening for Prostate Cancer;Serum;simulation;statistics;Subgroup;symposium;Systems Biology;Techniques;Training;Variant

PROJECT_TITLE: Integrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic Men


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cost Effectiveness Research;Genetic Testing;Genetics;Human Genome

PI_NAMEs: ZHA, SHAN  (contact)

PROJECT_TERMS: Address;analytical tool;Applications Grants;Area;Base Sequence;Biological Assay;cancer cell;Cancer Center Support Grant;Cancer Model;Cells;Chromosomal translocation;Chromosome Painting;Classification;Computer software;Consult;Consultations;cost effective;Cost Effectiveness Analysis;Cytogenetics;Cytogenetics Shared Resource;Data;data acquisition;Data Analyses;Dedications;Defect;design;Development;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA Sequence;Doctor of Philosophy;Double Strand Break Repair;Education;Equipment;experience;Experimental Designs;Fluorescent in Situ Hybridization;Funding;Future;Genome Stability;genome-wide;Genomic Instability;Genomic Segment;Goals;Grant;Herbert Irving Comprehensive Cancer Center;High-Throughput Nucleotide Sequencing;Hour;Human;Image;imaging system;innovation;instrument;instrumentation;Journals;Karyotype determination procedure;Kinetics;Knowledge;Leadership;Malignant Neoplasms;member;metropolitan;Microscope;Molecular;Molecular Cytogenetics;Morphology;Mus;Mutation;Nature;NCI Center for Cancer Research;Needs Assessment;Neoplasm Metastasis;new technology;New York;novel;operation;Organism;Paper;Pathway Analysis;Pathway interactions;Pattern;Pattern Recognition;Peer Review;Phenotype;premalignant;Preparation;Process;programs;prospective;Publications;Relapse;repaired;Reproducibility;Research;Research Personnel;Research Support;Resolution;response;Ribosomal DNA;Sampling;Secure;Services;skills;Source;Spectral Karyotyping;Stains;System;Techniques;Technology;technology platform;telomere;Time;Tissues;tool;Training;Training and Education;United States National Institutes of Health;Variant

PROJECT_TITLE: Molecular Cytogenetics Shared Resource


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: ALBUQUERQUE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Hydrogen sulfide (H2S) is an endogenous vasodilator compound produced in endothelial cells that regulates blood pressure and local blood flow. Production and/or activity of H2S is decreased in most cardiovascular diseases. The current understanding of how H2S signaling is mediated is not well understood, limiting therapeutic options to activate or repair the H2S signaling system. This proposal will investigate the functional significance and mechanisms leading to heterogeneous membrane cholesterol content among EC from different sites (Aim 1) and identify role of membrane cholesterol in regulating H2S signaling targets in vascular EC (Aim 2) to understand how this molecule signals in healthy systems, identifying potential targets that may be dysregulated in disease. The project's long-term goal is to identify novel targets for therapeutic intervention in cardiovascular diseases such as hypertension, stroke, and peripheral vascular disease.

PI_NAMEs: NAIK, JAY S (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Arteries;Binding;Biology;Blood flow;blood pressure regulation;Blood Vessels;Calcium;Carbon Monoxide;Cardiovascular Diseases;Cardiovascular system;Cell membrane;Cell Physiology;Cholesterol;cholesterol control;cholesterol trafficking;Circulation;Complex;Data;Disease;Disparate;Endothelial Cells;Endothelium;Event;Family;Functional disorder;Gene Expression;genetic approach;Goals;Heme;Homeostasis;Hydrogen Sulfide;Hypertension;Impairment;In Vitro;in vivo;innovation;Knowledge;Left;Mediating;Membrane;Membrane Lipids;Mesenteric Arteries;Mesentery;meter;new therapeutic target;Nitric Oxide;novel;Organ;Oxygenases;Pathway interactions;Peripheral Vascular Diseases;pharmacologic;Phospholipid Transfer Proteins;Potassium Channel;Principal Investigator;Production;programs;Property;Proteins;receptor;regional difference;Regulation;repaired;Reporting;Resistance;response;Role;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Site;Stroke;System;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Vanilloid;Vascular Endothelial Cell;Vasodilation;Vasodilator Agents;Work

PROJECT_TITLE: Regulation of H2S signaling in vascular function

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


PI_NAMEs: HIBSHOOSH, HANINA  (contact)

PROJECT_TERMS: Address;anti-cancer research;Automation;base;Board Certification;Breast;Cancer Center Support Grant;Cancer Diagnostics;Cells;Cellular biology;Certification;Clinical;Clinical Data;Collection;Consultations;cost;cost effectiveness;Data;Databases;Dedications;digital;digital imaging;DNA;Doctor of Philosophy;early onset;experience;Formalin;Freezing;Fresh Tissue;Funding;Generations;Genetic;Genome;Goals;Grant;Hematoxylin and Eosin Staining Method;Histology;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;innovation;insight;Journals;Link;Location;Lymphoma;Malignant Neoplasms;Marketing;Medical center;Medicine;member;Microdissection;Modeling;Molecular;molecular pathology;multiple omics;Nature;next generation;Notification;Oncology;Operating Rooms;operation;Organoids;Pancreas;Paraffin Embedding;Pathologist;Pathology;Patients;Peer Review;Phase;Physician Assistants;Play;Preparation;professor;programs;prospective;Proteins;Protocols documentation;PTEN gene;Publications;recruit;Research;Research Personnel;Research Support;Resected;Resource Sharing;Resources;Retrieval;RNA;sample collection;Schedule;service delivery;Services;Slide;Specimen;Stains;The Cancer Genome Atlas;Time;Tissue Microarray;Tissue Model;tissue processing;Tissue Procurements;Tissues;tool;Training;tumor;Tumor Bank;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Molecular Pathology Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

PI_NAMEs: OLIVE, KENNETH P. (contact)

PROJECT_TERMS: Address;Allografting;animal colony;animal imaging;Animals;Basic Science;bioimaging;Bioluminescence;Biometry;cancer cell;Cancer Center Support Grant;Cancer Model;Categories;Cell Line;Cells;Clinic;Clinical;Collaborations;Consultations;cost effectiveness;Cryopreservation;Crystallography;Data;data acquisition;Data Analyses;Databases;design;Development;Doctor of Philosophy;Drug Kinetics;Education;efficacy study;Ensure;Epidemiology;Equipment;experience;Experimental Designs;experimental study;Faculty;falls;Fluorescence;Funding;Generations;Genetic Engineering;genetic manipulation;Genomics;Goals;Grant;Growth;Herbert Irving Comprehensive Cancer Center;high throughput screening;Histopathology;Hospitals;Hour;IACUC;Image;Image Analysis;Imaging Device;imaging modality;imaging scientist;Imaging technology;implantation;in vivo;in vivo imaging;in vivo imaging system;Infrastructure;insight;Institutional Review Boards;instrument;instrumentation;Investigational Therapies;Investments;Journals;Kinetics;Laboratories;Leadership;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Medical center;Medicine;member;Methodology;microCT;Mission;Modeling;molecular pathology;mouse model;Mus;Nature;NCI Center for Cancer Research;Needs Assessment;New York;novel;Olives - dietary;operation;optical imager;optical imaging;Organoids;Paper;patient derived xenograft model;Patients;Peer Review;personalized medicine;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pre-clinical;precision oncology;Precision therapeutics;Presbyterian Church;Procedures;programs;prospective;Proteomics;Protocols documentation;Publications;Reproducibility;Research;Research Peer Review;Research Project Grants;Research Support;Resolution;Resource Sharing;Sampling;Scientist;Services;Small Animal Imaging Shared Resource;Spectrum Analysis;Techniques;Therapeutic Studies;Time;Tissue Sample;Toxic effect;Training;Training and Education;transcriptomics;translational cancer research;translational oncology;Translational Research;translational scientist;translational study;translational therapeutics;Translations;treatment response;tumor;tumor growth;ultrasound;United States National Institutes of Health;Universities;Work;X-Ray Computed Tomography;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Oncology Precision Therapeutics and Imaging Core


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The goal of this project is to evaluate small molecule inhibitors of methionine metabolism for their efficacy as anti-cancer therapeutics. This involves testing safety and efficacy of a novel drug combination designed to harness specific biochemical synthetic lethality of MTAP, MAT2A, and PRMT5 in mouse models of colorectal carcinoma (CRC). The ultimate goal is to expand treatment options in patients with CRCs for therapies designed to target a subset of cancer genotypes that are rarely present among CRC. We have demonstrated anti-cancer activity of our novel MTAP inhibitor alone. Here we evaluate a potential amplification of its anti- cancer efficacy in combination with a MAT2A inhibitor, as it relates to metabolism and gene expression. Finally, we will solve the transition state structure of the third enzyme involved in synthetic lethality, PRMT5, with the goal of designing new inhibitors with enhanced anti-cancer effects when used alone or in combination with MTAP and MAT2A inhibitors.

PI_NAMEs: BEDARD, GABRIEL T (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Accounting;Adenosine;Affect;analog;Animals;anti-cancer;anti-cancer therapeutic;anticancer activity;ApcMin/+ mice;Apoptosis;Architecture;Arginine;arginine methyltransferase;Biochemical;Body System;Body Weight;Cancer cell line;Cancer Model;cancer survival;cell growth;Cells;Clinical Trials;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Combined Modality Therapy;design;Development;Dose;driver mutation;drug candidate;Enzymes;experimental study;Familial Adenomatous Polyposis Syndrome;Foundations;Gene Expression;Genetic;Genotype;Glioblastoma;Goals;Growth;Heart;Histone H4;histone methylation;Histones;Human;Immunohistochemistry;In Vitro;in vivo;indexing;Individual;inhibitor;intestinal adenoma;Intestinal Neoplasms;Isotopes;Kinetics;Laboratories;Large Intestine Carcinoma;Lead;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolism;metabolomics;Methionine;methionine adenosyltransferase;Methionine Metabolism Pathway;Methylation;Methyltransferase;Molecular;Monitor;mouse model;Mus;neoplastic cell;novel;novel anticancer drug;novel drug combination;Oral;Pathogenesis;patient derived xenograft model;Patients;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Phase I/II Clinical Trial;Phenotype;Phosphorylases;Post-Translational Protein Processing;Primary Neoplasm;Proliferating;protein biomarkers;Protein Chemistry;Protein Inhibition;Protein-Arginine N-Methyltransferase;Proteins;Proteomics;Radiolabeled;rational design;Reaction;Recycling;Reporter;RNA Splicing;Route;S-Adenosylhomocysteine;S-Adenosylmethionine;Safety;safety testing;Schedule;single-cell RNA sequencing;small molecule inhibitor;Specificity;Structure;Tail;Techniques;Testing;Therapeutic;therapy design;Tissues;tool;Toxic effect;Transferase;Treatment Efficacy;tumor;tumor growth;Wild Type Mouse;Work

PROJECT_TITLE: Rational design of anti-cancer therapeutics harnessing the synthetic lethality of methionine metabolism and arginine methyltransferases


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PI_NAMEs: STOCKWELL, BRENT R. (contact)

PROJECT_TERMS: Address;Affinity;Biological Process;Cancer Biology;cancer cell;Cancer Center Support Grant;Cells;Cohort Analysis;Complex;Computer software;computerized data processing;Consultations;cost effectiveness;Crystallography;Data;Data Analyses;data visualization;Disease;DNA;Doctor of Philosophy;druggable target;Education;empowerment;Equipment;exosome;experience;Experimental Designs;experimental study;Funding;Gel;Goals;Herbert Irving Comprehensive Cancer Center;Human Resources;Hybrids;Immunoprecipitation;inhibitor;insight;instrument;instrumentation;Journals;Label;Ligands;Light;macromolecule;Malignant Neoplasms;mass spectrometer;Medicine;member;Methodology;Methods;Nature;NCI Center for Cancer Research;Needs Assessment;new technology;next generation;novel;Patients;Peer Review;Peptides;Pharmaceutical Preparations;Phenotype;Phosphopeptides;programs;prospective;Protein Analysis;protein complex;protein structure;Proteins;Proteome;Proteomics;Proteomics Shared Resource;Publications;Qualifying;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resource Sharing;response;RNA;Robotics;Sampling;screening;service providers;Services;Signal Pathway;Signal Transduction;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;structural biology;Structural Models;Structure;Techniques;Technology;technology development;technology validation;Time;Tissues;tool;Training;United States National Institutes of Health;Visualization

PROJECT_TITLE: Proteomics and Macromolecular Crystallography Shared Resource


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

PI_NAMEs: GAUTIER, JEAN  (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Area;Basic Science;biomedical informatics;Cancer Biology;cancer cell;Cancer Center Support Grant;cancer genetics;cancer genome;cancer genomics;cancer immunotherapy;cancer initiation;cancer therapy;cancer type;Catchment Area;Chemicals;chemotherapy;Chromatin;chromatin modification;Chromosomal translocation;Clinical;Clinical Research;Collaborations;Complex;Computational Biology;Development;Direct Costs;Disease;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Modification Process;DNA Repair;DNA Repair Pathway;Doctor of Philosophy;Double Strand Break Repair;Epigenetic Process;epigenome;epigenomics;Equilibrium;Evolution;Faculty Recruitment;Fostering;Funding;Genetic;Genetic Research;Genome;genome integrity;Genome Stability;genome-wide;genomic aberrations;Genomic Instability;Genomics;Glioblastoma;Goals;Grant;Heterogeneity;Immunotherapy;improved;insight;Investments;Journals;large cell Diffuse non-Hodgkin's lymphoma;Link;Maintenance;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;mathematical methods;Mathematics;member;Modification;Molecular;Mutation;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;operation;Pathologic;Peer Review;Peripheral;Physicians;Pilot Projects;population based;Population Research;Population Sciences;precision oncology;preservation;Process;Productivity;professor;programs;Publications;Radiation therapy;Radio;repaired;Research;research and development;Research Personnel;Resource Sharing;response;Schools;Scientist;Source;Systems Biology;T-Cell Lymphoma;Therapeutic;therapeutically effective;tool;Training;Translating;translational potential;Translational Research;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Biology;tumor microenvironment;Tumor Promotion;Tumor Suppression;tumorigenesis;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Cancer Genomics and Epigenomics