NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Kidney Disease

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Vascular calcification is common in chronic kidney disease (CKD) and associated with increased morbidity and mortality. This research project will enhance our understanding of the molecular mechanisms of vascular calcification, and identify novel target(s) for treatment of CKD-dependent vascular calcification.

PI_NAMEs: MIYAZAKI, MAKOTO  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;Aorta;Apoptosis;Apoptosis Inhibitor;Attenuated;biological adaptation to stress;Blood Vessels;calcification;Cardiovascular Diseases;CASP8 gene;Cause of Death;Cell Culture Techniques;Cell Death;Cells;Chemicals;Chronic;Chronic Kidney Failure;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Cultured Cells;cytokine;Data;disease model;effective therapy;endoplasmic reticulum stress;Event;Goals;In Vitro;in vivo;in vivo Model;Indoles;Inflammation;Inflammatory;inflammatory marker;inhibitor;Laboratories;Libraries;Link;Lipids;Medial;Mediating;Metabolism;mineralization;Minerals;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;novel;osteoblast differentiation;Osteoblasts;overexpression;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phosphorus;Phosphorylation;Play;Prevention strategy;Process;Publications;Regulation;Research Project Grants;RIPK1 gene;RIPK3 gene;Role;Scheme;screening;Series;Serum;Signal Transduction;small molecule libraries;Smooth Muscle Myocytes;Stimulus;Stress;Techniques;Testing;TLR4 gene;TNF gene;TNFRSF1A gene;Toxin;Transcriptional Activation;Uremia;Vascular calcification;Vascular Smooth Muscle;Vesicle

PROJECT_TITLE: The role of MLKL in the regulation of vascular calcification in CKD

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: AUGUSTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Pulmonary arterial hypertension (PAH) is a disease that is caused by structural changes in pulmonary arteries (PA) that promote high pulmonary arterial blood pressure and ultimately right heart failure and eventual death. In pulmonary tissue from experimental and human PAH we have discovered the upregulation of a novel gene, PDZ-Binding Kinase (PBK) that promotes smooth muscle cell proliferation. Specific pharmacological inhibitors of PBK reduce PAH in animal models and the goal of our studies is to define a role for PBK in the eitiology of PAH and establish the utility of PBK inhibitors as a therapeutic strategy to improve the morbidity and mortality of a disease for which there are few effective therapeutic options.

PI_NAMEs: BARMAN, SCOTT A;FULTON, DAVID J (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: adenoviral mediated;Animal Experiments;Animal Model;arterial remodeling;Binding;Binding Sites;Bioinformatics;Biotin;Blood Vessels;cancer cell;Cardiopulmonary;cell behavior;Cell Proliferation;Cells;Cessation of life;Characteristics;chromatin immunoprecipitation;Cytokinesis;Data;Diagnosis;digital;Disease;disease phenotype;Disease Progression;Dominant-Negative Mutation;Experimental Models;experimental study;gain of function;Gene Delivery;Gene Expression;Gene Fusion;Genes;Genetic;Goals;hemodynamics;Histones;Human;hypertensive;Image;improved;In Vitro;in vivo;indexing;Informatics;inhibitor;kinase inhibitor;Knock-out;Knockout Mice;Label;Ligation;loss of function;Luciferases;Lung;Malignant Neoplasms;Mass Spectrum Analysis;Medial;Mediating;Mediator;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nature;novel;novel therapeutic intervention;overexpression;Pathogenesis;Pathologic;Pathway interactions;PDZ-binding kinase;pharmacologic;Phosphorylation;Phosphorylation Site;Pilot Projects;Pneumonectomy;prevent;Prevention strategy;Proliferating;promoter;protein expression;Protein-Serine-Threonine Kinases;Proteins;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary arterial remodeling;Pulmonary artery structure;pulmonary vascular cell proliferation;pulmonary vascular remodeling;Pulmonary Vascular Resistance;Rattus;Reagent;Refractory;Resistance;right ventricular failure;Right Ventricular Hypertrophy;Right ventricular structure;RNA Interference;Rodent;Rodent Model;Role;Serine;Signal Pathway;Site;Smooth Muscle Myocytes;Testing;Therapeutic;therapeutically effective;Time;Tissues;Transcription Coactivator;ultrasound;Up-Regulation;Vascular remodeling;Vascular resistance;Vasodilation;Vasodilator Agents

PROJECT_TITLE: PBK: A novel mediator of VSMC proliferation and vascular remodeling in PAH

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-G(03)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Women's Health Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE This longitudinal study seeks to examine the role of sexual identity-specific individual and interpersonal protective factors as moderators of suicide risk, especially during developmental transition periods (e.g., into high school, college, or the workforce) that may disrupt their existing support networks, among young lesbian, bisexual, and other women who love women (YLBWLW). Participants will include 780 racially and ethnically diverse YLBWLW aged 14 to 30 who complete an online survey every three months over an 18-month period, with a subset of 70 completing an individual interview to explore in-depth the effects of changes in social connections over time, especially during transition periods, on suicide risk. This research will identify modifiable individual identity- and interpersonal social connectedness-level protective factors that will guide suicide prevention efforts across different levels of influence to promote mental health and reduce deaths by suicide among YLBWLW.

PI_NAMEs: SCHRIMSHAW, ERIC W;TALIAFERRO, LINDSAY A (contact)

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: Address;Affect;Age;aged;Area;Asian;Bisexual;Black race;college;community involvement;Data;Development;Distress;effective intervention;ethnic diversity;experience;Feeling;Feeling suicidal;Female;Funding;Gays;Glean;Health;health disparity;Heterosexuals;high risk;high school;Hispanic;Individual;insight;Interview;Lesbian;Life;Literature;Longitudinal Studies;Love;male;Mediation;men;Mental health promotion;Minority;minority children;minority stress;Motivation;Participant;Pathway interactions;peer;Persons;Population;Process;protective factors;psychologic;Qualitative Methods;racial diversity;recruit;Reporting;Research;Research Personnel;Risk;Risk Factors;Sampling;sexual identity;sexual minority;sexual minority group;sexual minority women;sexual role;social;social inclusion;social media;Social support;Stress;stressor;Subgroup;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;support network;Surveys;Testing;Theoretical model;theories;Time;United States National Institutes of Health;Woman;Youth

PROJECT_TITLE: Social connections preventing suicide ideation during developmental transitions among young sexual minority women


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE Diabetes imposes significant health and cost burdens on families, communities, and states in America and vulnerable groups like race/ethnic minorities, predominantly insured by Medicaid, are impacted the worst. We propose to study whether Medicaid managed care organizations (MMCOs) influence the healthcare and outcomes of Americans with diabetes differently in 12 states and the District of Columbia based on their race/ethnicity and sex. To do this, we will develop a dataset of MMCO and state program features over 2016- 2025; use Medicaid encounter data (T-MSIS) over the 10-year period to test whether MMCO and state program features, and the COVID-19 pandemic, affected the care of adults with diabetes; and add context to these empirical findings by interviewing key stakeholders in state Medicaid offices, MMCOs, and clinicians looking after Medicaid patients with diabetes.

PI_NAMEs: ALVA, MARIA LILIANA (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Admission activity;Adult;Affect;Age;American;Amputation;Behavior;beneficiary;black patient;Black race;burden of chronic illness;Caring;Categories;Characteristics;Classification;cohort;Communities;comorbidity;Contracts;cost;COVID-19;COVID-19 pandemic;Data;Data Analyses;data modeling;Data Set;Databases;design;Diabetes Mellitus;Diagnosis;disenfranchised population;Disparity;disparity reduction;District of Columbia;Economic Burden;Eligibility Determination;Emergency department visit;Enrollment;ethnic disparity;ethnic health disparity;ethnic minority;Ethnic Origin;evidence base;Expenditure;experience;family burden;Florida;foot;Future;Goals;Health;health disparity;Healthcare;Heterogeneity;high risk;Hospitalization;Hyperglycemia;improved;Incentives;Indigenous;Information Systems;insight;Insurance Carriers;Interview;Investigation;Investments;Kentucky;Latinx;Lawyers;Link;Managed Care;Managed Care Programs;marginalization;Marketing;Medicaid;medical specialties;Medicare/Medicaid;member;Methods;Minority;National Institute on Minority Health and Health Disparities;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Occupations;older adult;Outcome;pandemic disease;pandemic impact;Patients;Penetration;people of color;Performance;Persons;Pharmaceutical Preparations;Policies;Policy Maker;Population;post-COVID-19;Poverty;Preventive care;Primary Care;Privatization;Process;programs;Quality of Care;Race;racial disparity;racial health disparity;racial minority;Recommendation;Research;response;Risk;Sampling;Selection Bias;service utilization;Services;sex;Shock;socioeconomic disadvantage;Testing;Time;Titrations;trend;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Can Medicaid Managed Care mitigate race/ethnic health disparities in diabetes?

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Black very low birth weight infants are significantly less likely to receive mother’s own milk. The costs associated with adhering to pumping are borne by mothers and contribute to this disparity. This randomized controlled trial will test an intervention to offset costs associated with pumping and its cost effectiveness.

PI_NAMEs: JOHNSON, TRICIA J.;PATEL, ALOKA LAHOTI (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Affect;African American;Asian;authority;Behavior;Benchmarking;Birth;Birth Weight;Black race;breast pump;Bronchopulmonary Dysplasia;Child;comparative cost effectiveness;coping;cost;Cost Analysis;cost comparison;cost effectiveness;Cost Effectiveness Analysis;Data;Deposition;Disparity;disparity reduction;Donor Exclusions;Dose;economic evaluation;Economics;effectiveness evaluation;Effectiveness of Interventions;emotional distress;Employee;Equipment;Family;feeding;Funding;Goals;Health;Hispanic;Home;hospital readmission;Hospitalization;Hospitals;Hour;Household Heads;Human Milk;improved;Infant;infant outcome;Inferior;Infrastructure;innovation;International;Intervention;Lactation;late onset sepsis;Life;Low income;Maternal Behavior;maternal outcome;Measures;Mediating;Milk;milk volume;Morbidity - disease rate;Mothers;Native Americans;Necrotizing Enterocolitis;Neonatal Intensive Care Units;Neurodevelopmental Problem;Not Hispanic or Latino;novel;opportunity cost;Outcome;pasteurization;payment;Population;Poverty;Predisposition;primary outcome;Pump;Quality Indicator;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Regimen;Research;response;Risk;Risk Reduction;secondary outcome;Sepsis;standard of care;Testing;Training;Transportation;United States National Institutes of Health;Very Low Birth Weight Infant;Work

PROJECT_TITLE: Reducing Disparity in Receipt of Mother’s Own Milk in Very Low Birth Weight Infants: An Economic Intervention to Improve Adherence to Sustained Maternal Breast Pump Use

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative The National Plan to Address Alzheimer's disease has identified education of dementia care providers as a top priority to address the need for quality care for the population of persons with dementia that will triple in the next 30 years. This study will test new online interactive training for nursing home staff that improves staff communication and also reduces behavioral symptoms of persons with dementia that they care for. Innovative approaches to reach care providers are essential to achieve implementation of evidence-based practices to improve care.

PI_NAMEs: WILLIAMS, KRISTINE N. (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Administrator;Adoption;Adult;Age;Aggressive behavior;Alzheimer's Disease;Antipsychotic Agents;Bathing;Behavior;Behavior Control;Behavioral;Behavioral Symptoms;care providers;Caregiver support;Caring;Characteristics;Clinical Trials;Code;Cognitive;Communication;Control Groups;cost;Cost Analysis;cost effectiveness;Data;Data Set;Dementia;dementia care;Dependence;Diagnosis;Dissemination and Implementation;Education;effective intervention;empowerment;evidence base;Evidence based intervention;Evidence based practice;Exhibits;flexibility;Focus Groups;follow-up;Goals;Home Nursing Care;Honey;implementation evaluation;implementation strategy;Improve Access;improved;Incentives;Individual;Injury;innovation;Internet;Intervention;Interview;Knowledge;Long-Term Care;Maintenance;Measures;Methods;Mission;Modeling;Motivation;Names;Nonpharmacologic Therapy;Nursing Homes;online delivery;online version;Outcome;Outcome Measure;person centered;Persons;Pharmaceutical Preparations;pilot test;Population;pragmatic trial;primary outcome;process evaluation;programs;Psychological reinforcement;psychological symptom;psychosocial;Quality of Care;Quality of life;Randomized;Reaction;Reporting;Research;Research Personnel;Rural;rurality;side effect;Site;skills;skills training;Speech;Stress;Surveys;symptom management;Symptoms;Testing;Time;Training;Training Activity;Training Programs;Translating;Translations;United States Centers for Medicare and Medicaid Services;verbal;Withdrawal

PROJECT_TITLE: Changing Talk Online Training (CHATO): A National Trial to Reduce Behavioral Symptoms in Long Term Care Residents with Alzheimer's Disease and Other Dementias

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Public Health Relevance Statement  Human African Trypanosomiasis (HAT) is a vector-borne parasitic disease and, currently, drugs for curing the disease are few and often toxic to humans. The proposed studies in this application will explore the function of several cytokinesis regulators that are essential for Trypanosoma brucei to survive in its human host. These studies may identify novel targets for drug development.

PI_NAMEs: LI, ZIYIN  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Actomyosin;Address;Adopted;African Trypanosomiasis;Anterior;aurora B kinase;Automobile Driving;Biochemical;Biological;Cell division;Cells;cohort;Cytokinesis;Cytoskeletal Proteins;Cytoskeleton;daughter cell;Disease;drug development;Drug Targeting;Evolution;Foundations;Genetic;genetic approach;genetic regulatory protein;Goals;Human;human pathogen;insight;Investigation;Kinesin;Mediating;Microtubules;Molecular;Names;new therapeutic target;novel;Organism;Orphan;Outcome;Parasites;Parasitic Diseases;Pathway interactions;Pharmaceutical Preparations;Physiological;PLK1 gene;Protein Family;Protein Kinase;protein protein interaction;Proteins;public health relevance;Regulation;Regulatory Pathway;Research;Role;screening;Signal Pathway;Signal Transduction;Site;spatiotemporal;Testing;Therapeutic Intervention;Trypanosoma;Trypanosoma brucei brucei;vector-borne;Yeasts

PROJECT_TITLE: Mechanisms Of The Unusual Cytokinesis In Trypanosomes

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Narrative Transgender and gender diverse (TGD) individuals experience significant mental and physical health disparities resulting from minority stressors related to their gender identity. This study will provide a more nuanced and comprehensive understanding of a range of minority stressors that confer alcohol abuse and drug use risk and mental and physical health disparities while also highlighting potential etiologic mechanisms. Results derived will make a major contribution toward the evidence base required to develop effective, culturally informed, and gender-affirming treatment and multi-level prevention efforts specific to TGDAs.

PI_NAMEs: SALAZAR, LAURA F (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Acute;acute stress;Adult;Advertisements;Affect;Age;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;Anxiety;Behavior;Biological Markers;Birth;Blood Pressure;Body mass index;Buffers;Cardiovascular Diseases;Cheek structure;Chronic;Chronic stress;cisgender;Clip;Communities;community organizations;community-level factor;comorbidity;contextual factors;Data;design;Diabetes Mellitus;Discrimination;Distal;Drug usage;Drug Use Disorder;Ecological momentary assessment;ethnic identity;Ethnic Origin;Etiology;evidence base;Evidence based treatment;experience;follow-up;Frequencies;Gender;gender affirmation;gender affirming therapy;gender diverse;Gender Identity;Goals;Gonadal Steroid Hormones;Hair;Health;Health behavior;health care service utilization;health difference;health disparity;Health Status;Heterogeneity;High Prevalence;Individual;Individual Differences;individual variation;Inequity;Infrastructure;Interpersonal Violence;intersectionality;Intervention;Knowledge;Link;Lived experience;marginalization;Measurement;Measures;meetings;Mental Depression;Mental Health;Methodology;microaggression;minority stress;minority stressor;Modeling;nonbinary;Obesity;Observational Study;Online Systems;Outcome;outcome disparities;Participant;Pathway interactions;Patient Self-Report;peer;physical conditioning;Physiological;Policies;Population;Post-Traumatic Stress Disorders;Prevention;Prevention program;Prevention strategy;Process;prospective;Prospective, cohort study;Race;racial diversity;racial identity;recruit;Reduce health disparities;Research;resilience factor;Resources;Risk;Risk Factors;Role;Saliva;Sampling;sex assigned;sexual violence;Shapes;Sleep;social;Social Identification;social stigma;Social support;sociodemographics;Stigmatization;Stress;stressor;Subgroup;suicidal;Surveys;Swab;theories;transfeminine;transgender;transmasculine;treatment program;Victimization;Violence;Waist-Hip Ratio

PROJECT_TITLE: An intersectional approach linking Minority Stressors Experienced by Transgender and Gender Diverse Adults to Alcohol and Drug Use and comorbid Mental and Physical Health Outcomes

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Complementary and Integrative Health;Neurosciences;Nutrition;Obesity;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Project Narrative Opioid use disorder and obesity are major comorbid public health concerns that are increasing in national prevalence, and that convey increased risk for negative health outcomes in patients. It is not known if dietary intake among individuals with obesity might underlie differential sensitivity to opioid drugs causing differences in therapeutic effectiveness for pain management or leading to the development of opioid use disorder. This proposal will use animal models to evaluate the effects of eating a high fat, low fat or ketogenic diet on sensitivity to the therapeutic, rewarding and adverse effects of morphine, as well as overlapping brain regions implicated in reward, feeding and nociception.

PI_NAMEs: SERAFINE, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: BECK, LAWRENCE A

PROJECT_TERMS: abuse liability;Acute;Adverse effects;Analgesics;Animal Model;antinociception;Behavioral;behavioral sensitization;Biological Assay;Brain region;brain tissue;Carbohydrates;Chronic;chronic pain management;chronic painful condition;Communication;comorbidity;conditioned place preference;Constipation;Consumption;Corpus striatum structure;Data;Data Analyses;Data Collection;delta opioid receptor;Dependence;Development;Diagnosis;Diet;dietary control;Dietary History;Dietary intake;Dopamine Receptor;Eating;experience;Experimental Designs;Fat-Restricted Diet;Fatty acid glycerol esters;feeding;Food;FOS gene;Future;Gastrointestinal Transit;graduate student;Health;High Fat Diet;high risk;Hispanic-serving Institution;Hypothalamic structure;indexing;Individual;Injections;Insulin;Insulin-Like Growth Factor I;IRS2 gene;kappa opioid receptors;ketogenic diet;Leptin;Link;Measures;Mentors;Mentorship;Methods;midbrain central gray substance;minority scientist;molecular marker;Morphine;morphine administration;mortality;Naloxone;neural;neurochemistry;Nociception;Obesity;Opioid;Opioid Analgesics;opioid overdose;opioid use disorder;Outcome;overdose death;Pain management;pain sensitivity;Patients;Pharmaceutical Preparations;Physiological;prescription opioid;Prevalence;Proto-Oncogene Proteins c-akt;Public Health;Publications;Rattus;Recording of previous events;Recreation;Research;reward processing;Rewards;Risk;Rodent;Slice;Source;Stimulant;Students;System;Tail;Texas;Therapeutic;Therapeutic Effect;therapeutic effectiveness;Training;Treatment Protocols;undergraduate student;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;Water;Weight Gain;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: The effects of eating a high fat diet on the therapeutic and abuse-related effects of morphine


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE This research will explain how Latinx adolescents’ experiences of adversity tied to the U.S. anti-immigrant environment, activity space marginalization, and COVID-19 pandemic influence later health risks and social mobility as Latinx youth transition to adulthood. Building on Caminos, an ongoing study of 547 Latinx youth and, for 50% (n = 271) of them, their mothers, study activities will include collecting five additional annual time points of survey data, hair and salivary cortisol, and waist circumference. Findings will inform policy and practice by identifying (1) family, biological, and behavioral health stress processes that explain links between adolescent adversity and health risks and social mobility and (2) community and interpersonal, family, and youth protective factors that mitigate adversity impacts on later health risks and social mobility.

PI_NAMEs: ROCHE, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: acute stress;Adolescence;Adolescent;adolescent health;Adult;Age;Alcohol consumption;Area;Asthma;Behavior;behavioral health;Biological;Biology;Buffers;Censuses;Cessation of life;Chronic;Chronic Disease;Chronic stress;Clinical;cohesion;cohort;Cohort Studies;Communities;Community Relations;COVID-19 impact;COVID-19 pandemic;critical period;Data;Development;Diabetes Mellitus;Discrimination;disorder risk;early adolescence;Education;emerging adult;Environment;ethnic identity;Ethnic Origin;Event;experience;Exposure to;externalizing behavior;Face;Family;Family member;Feeling suicidal;Female;Funding;Goals;Growth;Hair;Health;health disparity;Hydrocortisone;Immigrant;Immigration;Individual;insight;Interpersonal Relations;Job loss;junior high school;Knowledge;Latinx;Latinx population;Link;Longitudinal Studies;male;Manuscripts;marginalization;maternal depression;Measures;Mediating;Mediation;Mental Health;Methods;Modeling;Mothers;National Institute of Child Health and Human Development;Neighborhoods;Obesity;obesity risk;Outcome;Output;pandemic disease;Parents;Pediatrics;peer support;Policies;Politics;Process;programs;protective factors;Public Health;Race;Reporting;Research;resilience;response;Rights;Risk;risk mitigation;Salivary;Sampling;Science;sedentary lifestyle;sex as a biological variable;Shapes;Sleep Disorders;Social Mobility;Social support;Socialization;Stress;stressor;Stretching;substance use;suburb;Surveys;Symptoms;Testing;theories;Time;transition to adulthood;translational impact;Unhealthy Diet;waist circumference;Weather;young adult;Youth

PROJECT_TITLE: A Longitudinal Study of Adversity, Stress Processes, and Latinx Health from Adolescence to Young Adulthood

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Diabetes;Dietary Supplements;Genetics;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative This translational project aims to improve our understanding of Type 1 Diabetes by defining how probiotic supplementation influences immune activity and the rate of disease progression.

PI_NAMEs: CABRERA, SUSANNE M;HESSNER, MARTIN J (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Acceleration;age related;animal old age;Antibiotic Therapy;Antibiotics;Autoantibodies;Beta Cell;Biological Assay;Cell Physiology;Cellular Stress;chemokine;Child;clinically significant;Controlled Environment;Coronary Arteriosclerosis;cytokine;Dependence;design;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;Diet;Disease;Disease Progression;dysbiosis;environmental change;Environmental Risk Factor;Equilibrium;Event;Exhibits;Exposure to;Family;Fostering;Frequencies;Genetic;Genetic Risk;Genetic Transcription;Genotype;gut microbiota;high risk;Human;Hypoglycemia;Immune;immunoregulation;improved;Incidence;Inflammation;Inflammatory;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interleukin-1;Interleukin-10;Intestinal permeability;islet autoimmunity;juvenile animal;Lactobacillus plantarum;Major Histocompatibility Complex;Measures;Mediating;metabolome;microbiota;microbiota composition;microorganism antigen;Microvascular Dysfunction;Modeling;monocyte;Morbidity - disease rate;mortality;Neonatal;Onset of illness;Partial Remission;patient population;Patients;Pattern recognition receptor;Pediatric cohort;Peripheral;Phenotype;Placebo Control;Plasma;Positioning Attribute;Predisposition;prevent;primary outcome;proband;probiotic supplementation;Probiotics;Qualifying;Randomized;Rattus;Receptor Activation;Regulation;Regulatory T-Lymphocyte;Replacement Therapy;Residual state;Resistance;Risk;Risk Reduction;Rodent;Rodent Model;secondary outcome;Siblings;Signal Transduction;single-cell RNA sequencing;Structure of beta Cell of islet;Supplementation;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic Agents;Transforming Growth Factor beta;Virus;Virus Diseases;Volatile Fatty Acids;western diet

PROJECT_TITLE: Reducing innate inflammation in new onset T1D with Lactobacillus plantarum

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Helicobacter pylori is a type of bacteria that infects the stomach of half of the world’s population. It causes chronic inflammation, and can lead to peptic ulcer disease as well as progression to precancerous stages and to stomach cancer, the third leading cause of cancer deaths worldwide. Our Servicemen/women are frequently exposed to H. pylori when deployed to areas where this infection is very frequent, and they can acquire pathogenic strains that are harder to treat and associated with carcinogenesis. Antibiotics are not useful once precancerous lesions occur. We will further investigate mechanisms, discovered by our Lab, by which H. pylori causes inflammation that leads to tissue injury, DNA damage, gene mutations, and thus carcinogenesis. Using novel model systems, we will focus on dysfunction of polyamine molecules and their role in aberrant responses in epithelial cells that can undergo neoplastic transformation. Our studies will result in new understanding of H. pylori-induced disease and rational strategies for risk assessment and prevention of disease progression.

PI_NAMEs: WILSON, KEITH T. (contact)

PROJECT_TERMS: 3-Dimensional;active duty;Animal Model;Animals;Antibiotics;Area;Attenuated;Back;Bacteria;beta catenin;Biological;Biological Markers;Biological Models;Biopsy;Cancer Etiology;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;Cell Physiology;Cessation of life;chemokine;Chemoprevention;Chronic;Chronic Gastritis;Classification;Clinical;CRISPR/Cas technology;deoxyhypusine synthase;Development;Disease;Disease Progression;disorder prevention;DNA Damage;Dysplasia;Effectiveness;Enzymes;Epithelial Cells;Epithelium;Etiology;Exhibits;exome sequencing;experience;Exposure to;Functional disorder;FVB/N Mouse;gastric carcinogenesis;Gastric mucosa;gastric organoids;Gastrins;Gastritis;Gene Mutation;Generations;Genomic Instability;Genomics;Gerbils;Grant;Health;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;high risk;Human;in vivo;Induced Mutation;Infection;Infectious Agent;Inflammation;inhibitor;innovation;insight;Insulin;interest;Lead;Lesion;Link;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Metabolism;Microbe;Military Personnel;Modeling;Molecular;Mucositis;Mus;mutant mouse model;Mutation;Neoplastic Cell Transformation;novel;Organoids;Ornithine Decarboxylase;pathogen;Pathogenicity;Pathway interactions;Patients;Peptic Ulcer;Phenotype;Plants;polyamine oxidase;Polyamines;Population;premalignant;Prevalence;prevent;Process;programs;Proteins;Proteomics;Putrescine;recruit;Reporter;Research;response;Risk;Risk Assessment;Role;service member;Spermidine;Spermine;Stomach;Stomach Diseases;System;Testing;tissue injury;Tissues;tool;Transgenes;Translations;Validation;Veterans;Woman

PROJECT_TITLE: Dysregulated Polyamine Metabolism in H. pylori-associated Gastric Inflammation and Disease Progression


ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE There is a pressing need for new therapies for obesity and type 2 diabetes, either alone or to complement current treatments. This proposal will establish the molecular mechanisms underlying control of glucose homeostasis by a newly discovered adipokine. Our project is anticipated to lead to a better understanding of how glucose is regulated by insulin-independent pathways, ultimately leading to facilitate the translation to human clinical applications.

PI_NAMEs: SVENSSON, KATRIN JENNIFER (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Address;Adipocytes;adipokines;Adipose tissue;Animals;Biochemical;Biological;Blood Glucose;blood glucose regulation;Cardiovascular Diseases;Cell Surface Receptors;Chronic;clinical application;combat;Complement;Data;Diabetes Mellitus;diabetic;Endocrine;Energy Metabolism;Engineering;euglycemia;expression vector;Fatty acid glycerol esters;feeding;Genetic;Glucose;glucose metabolism;Glucose tolerance test;glucose uptake;Goals;High Fat Diet;Homeostasis;Hormonal;hormonal signals;Hormones;Human;improved;In Vitro;in vivo;innovation;insight;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;Insulin Signaling Pathway;Knockout Mice;Liver;Maintenance;Mammals;Mediating;Mediator;Medical;Metabolic;Metabolic dysfunction;metabolic phenotype;Methods;Molecular;Monitor;multidisciplinary;Mus;Muscle;Muscle Fibers;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;obesity treatment;Outcome;overexpression;Pathway interactions;pharmacologic;Pharmacological Treatment;Physical activity;Physiological;Physiology;PI3K/AKT;Play;Polypeptide Hormones;Proteins;Proteomics;Public Health;receptor;Receptor Protein-Tyrosine Kinases;Recombinant Proteins;Recombinants;Reproducibility;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Surface;Therapeutic;Therapeutic Agents;therapeutic target;Tissues;tool;translation to humans;translational potential;Weight Gain

PROJECT_TITLE: Control of glucose homeostasis through the insulin-independent Isthmin pathway

STUDY_SECTION: MCE

STUDY_SECTION_NAME: Molecular and Cellular Endocrinology Study Section[MCE]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HATTIESBURG

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative: The Mississippi INBRE is designed to improve biomedical research in the state and positively impact student training. This will be accomplished by 1) supporting the research enterprise at primarily undergraduate institutes, 2) Promoting collaboration among biomedical researchers, and 3) by training students in biomedical research and increasing diversity in the health-related career workforce.

PI_NAMEs: LUCAS, KELLY  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Area;Bacteriophages;Biomedical Research;career;Centers of Research Excellence;Collaborations;Communicable Diseases;Communities;community based participatory research;community engagement;community organizations;Data Analyses;Data Science Core;Dedications;design;Development;Diverse Workforce;Education;Educational Curriculum;Eligibility Determination;empowerment;Enrollment;experience;Faculty;faculty research;Funding;Funding Mechanisms;Future;Goals;Grant;Health;health care availability;health disparity;health inequalities;Healthcare;higher education;Home;Human;human capital;Human Resources;improved;Infrastructure;Institution;instrumentation;Investments;Knowledge;Laboratories;Leadership;Malignant Neoplasms;Mississippi;next generation;Obesity;outreach;Phase;Physicians;population health;Productivity;programs;recruit;Research;Research Activity;Research Design;Research Infrastructure;Research Institute;Research Personnel;Research Support;Resources;Scholars Program;Science;Scientist;Secure;Services;skills;STEM career;student participation;student training;Students;Training;Training and Education;Training Programs;undergraduate research experience;undergraduate student;underserved community;United States;United States National Institutes of Health;workforce needs

PROJECT_TITLE: Mississippi INBRE


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PHR: Project Narrative: The Mississippi INBRE Administrative Core coordinates all aspects of the MS INBRE. This  will be accomplished by 1) providing leadership across activities, 2) facilitate the mission of the development  research project program and CETC to support research projects 3) build a pipeline of students pursuing  biomedical careers, 4) Broaden participation in underrepresented groups, 5) promote sustainability of research  infrastructure, 6) Represent MS at the national level, and 3) evaluate the effectiveness of the network.

PROJECT_TERMS: Address;Administrator;Advisory Committees;African American population;Biomedical Research;broadening participation research;career;Centers of Research Excellence;Collaborations;college;Communication;community engagement;community organizations;Core Facility;Data Science Core;design;Development;Diverse Workforce;Education;Educational Curriculum;Educational workshop;effectiveness evaluation;Ensure;Evaluation;experience;Faculty;Funding Opportunities;Goals;Health;health disparity;improved;Infrastructure;Institution;instrumentation;interest;Internships;Leadership;Mentors;Minority;Mission;Mississippi;next generation;online course;Outcome;Policies;Procedures;Productivity;Program Research Project Grants;programs;Recommendation;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Role;Science;Services;skills;student training;Students;summer research;support network;Training;training opportunity;undergraduate research experience;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Rural Health;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Nurse AMIE Project Narrative Rural patients with metastatic cancer are less likely to have access to high quality supportive care. This may have a negative effect on survival and well-being. We will conduct a randomized controlled trial to assess the survival benefits of a high quality technology based supportive care platform among 344 underserved, low income patients with metastatic cancer living in rural Pennsylvania or West Virginia.

PI_NAMEs: SCHMITZ, KATHRYN H. (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Advanced Malignant Neoplasm;Cancer Patient;care systems;Client satisfaction;Clinical;Code;common symptom;community advisory board;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;County;Data;Decision Trees;Disseminated Malignant Neoplasm;Distress;Enrollment;evidence base;experience;Fatigue;follow-up;Goals;Health;health related quality of life;Hospitals;improved;Individual;Internet;Intervention;Length;Low income;Malignant Neoplasms;Medical;Medical center;men;Metastatic breast cancer;Nurses;Oncology;opportunity cost;Outcome;Pain;participant enrollment;Patient Self-Report;Patients;pedometer;Pennsylvania;Personal Satisfaction;personalized decision;Physical activity;pilot test;primary outcome;Probability;psychosocial;Quality of life;Quality-Adjusted Life Years;Randomized;Randomized, Controlled Trials;Reporting;Research;Resistance;Resources;Rural;rural area;Rural Health;rural patients;rural setting;rural underserved;rurality;Schedule;Self Care;Services;Severities;Site;Sleep;Supportive care;Surveys;symptom cluster;symptomatic improvement;Symptoms;Tablets;Technology;Telephone;Travel;treatment as usual;Treatment-Related Cancer;tumor;Uncertainty;Universities;urban setting;usual care arm;Visit;West Virginia;Woman;Work

PROJECT_TITLE: Nurse AMIE: Addressing Metastatic Individuals Everyday in Rural PA and WV


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative: The Mississippi INBRE Data Science Core will provide essential analytical and  computational resources that support many programmatic activities. It is a keystone of research  infrastructure due to deep integration with other Cores. This will be accomplished by 1) providing  bioinformatic support for high throughput data sets from genomics, transcriptomics, proteomics, and  metabolomics/lipidomics experiments; 2) Offering training in Artificial intelligence technology to  enhance biomedical and community health research; 3) support molecular modeling needs for  research and education; and 4) Consult on data management practices for appropriate statistical  analysis of data.

PI_NAMEs: ZHENG, YUFENG  (contact)

PROJECT_TERMS: Acceleration;Access to Information;Address;Algorithms;Area;Artificial Intelligence;Behavior;Binding;Biochemistry;Bioinformatics;Biological;Biomedical Research;Biometry;Calibration;community based participatory research;community engagement;Community Health;Complement;Complex;complex data;computer infrastructure;Computer software;computerized tools;Computing Methodologies;computing resources;Consult;Consultations;convolutional neural network;Core Facility;curriculum development;Custom;Data;Data Analyses;data management;Data Science;Data Science Core;Data Set;Database Management Systems;Databases;Dedications;deep learning;deep neural network;design;Discipline;DNA;Docking;Education;Educational process of instructing;Educational workshop;Environment;epidemiologic data;Epidemiology;experimental study;Faculty;Genetic;genetic information;genomic data;Genomics;Goals;Health;health data;High-Throughput Nucleotide Sequencing;improved;Infrastructure;insight;Institution;instrumentation;laboratory curriculum;large scale data;lipidomics;Machine Learning;metabolomics;Methods;Mission;Mississippi;Molecular;molecular modeling;operation;Pharmaceutical Preparations;Pharmacologic Substance;Practice Management;Productivity;programs;Proteomics;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;science education;Services;side effect;small molecule;Societies;Statistical Data Interpretation;Structure;student training;Students;Techniques;Technology;tool;Training;Training and Infrastructure;training opportunity;transcriptome sequencing;transcriptomics;undergraduate student;Variant;virtual reality;Visualization;Visualization software;whole genome;Work

PROJECT_TITLE: Data Science Core


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Although most subcutaneous, dermal and marrow adipocytes primarily exist in temperatures well below 37oC, the role of environmental temperature has largely been neglected in our consideration of their molecular and functional characteristics. Our preliminary data indicate that adaptation of cultured adipocytes to cooler temperatures causes profound changes to their molecular and physiological characteristics. Further exploration of these adaptive mechanisms may help uncover novel mechanisms of adaptive thermogenesis and identify targets for pharmacologic interventions to increase energy expenditure and combat incidence of obesity and diabetes.

PI_NAMEs: MACDOUGALD, ORMOND A (contact)

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Afferent Neurons;Animals;ATP Synthesis Pathway;Back;Behavioral;Blood Vessels;Body Temperature;Brain;Brown Fat;Calcium;Cell Physiology;Cells;Characteristics;Chest;cold temperature;combat;Complex;Creatine Kinase;Cultured Cells;Data;Dermal;Diabetes Mellitus;Distal;Energy Metabolism;Exercise;experimental study;Futile Cycling;Gene Expression;Genetic;Genetic Transcription;Hour;Housing;Human;Hypothalamic structure;improved;Incidence;insight;Intervention;Knowledge;Limb structure;lipid metabolism;Literature;Mammals;Marrow;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Molecular;Monounsaturated Fatty Acids;Mus;neglect;Neurons;novel;Nutrient;Obesity;Oxygen Consumption;Pathway interactions;Peripheral;pharmacologic;Physiologic Thermoregulation;Physiological;Physiology;Population;posttranscriptional;programs;Property;Protons;Rattus;Research;response;RNA-Binding Proteins;Rodent;Role;Saturated Fatty Acids;Series;Shapes;Shivering;Signal Transduction;Skin;spine bone structure;Stearoyl-CoA Desaturase;subcutaneous;Subcutaneous Tissue;System;Temperature;Testing;thermal stress;Thermogenesis;tibia;transcriptome sequencing;Triglycerides;Unsaturated Fats;vasoconstriction;Visceral;Work

PROJECT_TITLE: Mechanisms by which adipocytes adapt to cool environmental temperatures

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cancer;Kidney Disease;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tuberous Sclerosis;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative A majority of patients with Tuberous Sclerosis Complex (TSC) develop kidney angiomyolipomas (AMLs) that can cause renal insufficiency and life-threatening spontaneous hemorrhages, for which the only current therapy is everolimus. Everolimus has limited anti-tumor efficacy, and tumor re-growth frequently occurs after treatment is interrupted due to side effects. In order to investigate the mechanisms of tumor resistance to everolimus therapy, we have generated AML tissues from patient-derived induced pluripotent stem cells, which we will use to test novel therapies with increased efficacy.

PI_NAMEs: LEMOS, DARIO  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Acceleration;Address;Adverse effects;Aftercare;Alleles;alpha Actin;Anatomy;Angiomyolipoma;antitumor effect;Apoptosis;Apoptotic;BCL-2 Protein;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;Benign;BH3 Domain;Binding Proteins;Biological Assay;Biology;BIRC3 gene;Blood Vessels;capsule;CASP3 gene;CCI-779;CDKN1A gene;Cell Death;Cell Death Induction;Cell Survival;Cells;Cellular Morphology;Cessation of life;Characteristics;Combined Modality Therapy;Common Neoplasm;Complex;CRISPR/Cas technology;Cytoplasm;Cytostatics;Data;design;Development;Drug Combinations;Drug Delivery Systems;drug testing;efficacious treatment;efficacy evaluation;experimental study;Family;FRAP1 gene;Generations;Genes;Genetic Engineering;glycoprotein NMB;Goals;Growth;Growth Factor;Half-Life;Hemorrhage;Human;immunodeficiency;In Vitro;in vivo;in vivo evaluation;induced pluripotent stem cell;inhibitor therapy;insight;Insulin;Interruption;Kidney;Kidney Failure;Kidney Neoplasms;kinase inhibitor;Knock-out;Life;melanocyte;mimetics;Mitochondria;Modeling;Molecular;Molecular Biology;mTOR Inhibitor;multicatalytic endopeptidase complex;Mutation;nanocarrier;nanoparticle;nanotherapy;novel;novel therapeutics;Organoids;patient derived induced pluripotent stem cells;Patients;pharmacologic;Play;PMAIP1 gene;Population;pre-clinical;premature;prevent;protein protein interaction;Proteins;Rattus;Renal Angiomyolipoma;Reporting;Repression;Resistance;Resistance development;resistance mechanism;Retroperitoneal Hemorrhage;Rodent;Role;Rupture;Sampling;SDZ RAD;side effect;Signal Pathway;small hairpin RNA;Smooth Muscle;Specificity;Testing;Time;Tissue Engineering;Tissues;tool;Transcriptional Activation;transcriptome;Transgenic Mice;Transplantation;TSC1 gene;TSC2 gene;Tuberous Sclerosis;tumor;Tumor Promotion;Up-Regulation;Vascularization;Xenograft procedure

PROJECT_TITLE: Elucidation of Tumor Resistance Mechanisms in Tuberous Sclerosis Complex-Associated Renal Angiomyolipoma for the Design of Novel Nanotherapies

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Genetics;Prevention

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE  Proper control of gene expression is critical for organismal development, cellular response to environmental signals or stress, and the prevention of disease states. The proposed work seeks to identify fundamental mechanistic principles that underpin the control of gene expression at the level of RNA synthesis. Thus, these studies will provide key insights into the cellular mechanisms that govern development, enable cells to respond to environmental signals or stress, and that prevent the emergence of disease.

PI_NAMEs: NICKELS, BRYCE EDWARD (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Architecture;Bacteria;base;Biological;Biological Models;Cells;Code;Complex;design;Development;Disease;disorder prevention;DNA Sequence;DNA-Directed RNA Polymerase;Environment;Escherichia coli;Eukaryota;experimental study;flexibility;Future;Gene Expression;Genes;genetic regulatory protein;Genetic Transcription;Genome;Growth;In Vitro;in vivo;insight;Knowledge;Measurement;method development;Modeling;Monitor;Mutation;Organism;prevent;Reaction;Regulation;response;RNA chemical synthesis;Signal Transduction;Site;Specific qualifier value;Stress;System;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Transcription: Mechanism and Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Aging;Burden of Illness;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Relevance This project will rigorously and neutrally estimate the health and economic impacts of the COVID-19 pandemic and policy responses to it. These estimates will inform policy makers and the public of the costs and benefits of policy responses, including lockdowns, mask requirements, and vaccinations, to support informed, civil discourse and policy making.

PI_NAMEs: WEINBERG, BRUCE A (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Affect;Age;Area;Cell Nucleus;Cities;Communities;Complex;Consumption;cost;Costs and Benefits;Country;County;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;data modeling;Developing Countries;Diffusion;Disparity;Econometric Models;econometrics;economic cost;economic impact;economic outcome;Economics;Ensure;Environment;Epidemic;Ethnic Origin;experience;frontier;Future;future outbreak;future pandemic;Gender;gender difference;Geography;Health;Health Care Costs;Herd Immunity;improved;Incidence;Infection;infection rate;interest;latent infection;Literature;Living Arrangement;Location;Marketing;Masks;Measurement;Measures;Mental Health;Modeling;mortality;National Center for Advancing Translational Sciences;novel;Nursing Homes;opioid epidemic;Outcome;outcome disparities;pandemic disease;Parameter Estimation;Performance;Pilot Projects;Policies;Policy Maker;Policy Making;Prevalence;Proxy;Public Health;Race;Research;response;Rest;Risk;Running;simulation;Structure;Testing;Time;Update;Vaccination;Virus;Work

PROJECT_TITLE: The Health and Economic Impacts of COVID-19 and Policy Responses


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PHR: Project Narrative: The Mississippi INBRE Instrumentation and Services Core provides essential research  infrastructure in the form of advanced instrumentation and also expertise. The capabilities offered through this  Core are essential for the completeness of biomedical research in Mississippi. This will be accomplished by 1)  providing access to instruments and expertise, 2) educate researchers and students in cutting-edge  approaches, and 3) maintaining the competitive edge of Core services.

PI_NAMEs: GARRETT, MICHAEL R (contact)

PROJECT_TERMS: Academy;Basic Science;Bioenergetics;Biological;Biological Assay;biological systems;Biomedical Research;Cell Line;Cell Nucleus;Cell Physiology;Cells;Cellular Assay;cellular imaging;Cellular Structures;Centers of Research Excellence;Clinical Research;Complex;Computers and Advanced Instrumentation;Consultations;Core Facility;cost;CRISPR/Cas technology;Data;Data Science Core;Data Set;Dedications;Development;Discipline;Education;Enhancement Technology;Ensure;Environment;Epigenetic Process;equipment acquisition;Extramural Activities;Faculty;Faculty Workshop;Fostering;Funding;gene editing technology;Gene Expression;gene function;gene-editing approach;Generations;Genes;Genetic Variation;genome-wide;Genomics;Goals;Grant;High-Throughput Nucleotide Sequencing;Human Resources;Hybrids;Image;Imaging technology;improved;Infrastructure;innovation;insight;Institution;Instruction;instrument;instrumentation;interdisciplinary collaboration;Investigation;Link;lipidomics;Lipids;loss of function;Maintenance;meetings;metabolomics;Methodology;Methods;Mission;Mississippi;Molecular;Multiomic Data;multiple omics;new technology;novel;Organ;Organism;Peer Review;Phenotype;Physiological;Process;programs;Proteins;Proteomics;Publications;Research;research and development;Research Infrastructure;Research Institute;Research Personnel;Resolution;Resources;Sampling;Science;screening;service delivery;Services;single-cell RNA sequencing;student training;Students;success;summer student;Supervision;symposium;Technical Expertise;Techniques;Technology;Tissues;tool;Training;Training and Education;training opportunity;Transcript;transcriptome sequencing;transcriptomics;undergraduate student;Variant;Visualization

PROJECT_TITLE: Instrumentation and Services Core


NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Base excision repair (BER) is a critical process for preventing the mutagenic and lethal consequences of DNA lesions such as oxidative base damage and abasic sites. BER pathway requires a tight communication between repair proteins. To better understand the mechanism of DNA damage processing that is not always precise, this proposal will elucidate how DNA repair proteins coordinate to execute accurate repair of DNA damage at biochemical level and atomic resolution.

PI_NAMEs: CAGLAYAN, MELIKE  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Architecture;base;Base Excision Repairs;Biochemical;biophysical techniques;Cells;Chemicals;Communication;Complement component C1;Cryoelectron Microscopy;Disease;DNA;DNA Damage;DNA lesion;DNA ligase I;DNA Ligases;DNA Repair;DNA Repair Gene;DNA-Directed DNA Polymerase;Environmental Hazards;Enzymes;Exposure to;Failure;Genes;Genomic DNA;Genomic Instability;Human;Impairment;Individual;interdisciplinary approach;Knowledge;Laboratories;Ligase;Malignant Neoplasms;Modification;Molecular;Multiprotein Complexes;Mutation;Outcome;Pathway interactions;Play;Positioning Attribute;prevent;Process;programs;Proteins;Repair Complex;repair function;repaired;Research;Resolution;Roentgen Rays;Role;scaffold;Scaffolding Protein;Scientific Advances and Accomplishments;seal;Site;stem;Variant;Work;X-Ray Crystallography

PROJECT_TITLE: DNA ligase activities during base excision repair coordination

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Mental Health;Physical Activity;Prevention;Telehealth

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: More than three-quarters of the 30 million Americans with type 2 diabetes (T2D) are unable to meet recommended levels of physical activity, and current intensive programs to improve physical activity have been difficult to integrate into real-world clinics. We propose a randomized controlled trial of a remotely delivered program that uses positive psychology exercises (designed to increase optimism, motivation, gratitude, and confidence) combined with a standard physical activity program. If this new combined positive psychology program is more successful than the standard physical activity program alone in boosting activity, it could eventually be used in routine clinical practice to improve the health of people with T2D.

PI_NAMEs: HUFFMAN, JEFF C (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accelerometer;Address;Affect;American;Attention;behavior change;Behavior Therapy;Cardiac;cardiometabolic risk;cardiovascular risk factor;Clinic;Clinical;clinical practice;clinically relevant;Cognitive;comparison intervention;Complications of Diabetes Mellitus;Counseling;Death Rate;design;Diabetes Mellitus;diabetes self-management;Effectiveness;efficacy evaluation;efficacy trial;Elements;Exercise;exercise intervention;exercise program;Expectancy;glycemic control;Grant;gratitude;Health;improved;innovation;internal control;Intervention;intervention effect;intervention refinement;Link;Measures;Mediating;Mediation;Mediator;Mental Depression;Modeling;moderate-to-vigorous physical activity;mortality;Motivation;motivational enhancement therapy;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;optimism;Outcome;Outcome Study;Patients;Performance;Personal Satisfaction;Persons;Physical activity;pilot trial;Population;primary outcome;process optimization;programs;prospective;Protocols documentation;psychologic;Psychological Factors;Psychology;Public Health Practice;Randomized;Randomized, Controlled Trials;Recommendation;remote delivery;Resolution;Risk;Risk Factors;secondary outcome;sedentary;Self Efficacy;Site;standard of care;tailored text messaging;Telephone;telephone session;Testing;Text Messaging;Theoretical model;Time;United States National Institutes of Health;Well in self;Work

PROJECT_TITLE: A novel psychological-behavioral intervention to promote physical activity in type 2 diabetes.

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Narrative MyGoals for Healthy Aging is a randomized controlled trial testing if a novel anti-poverty program slows biological aging in highly disadvantaged public housing recipients, including by inducing changes in risk factors for Alzheimer's disease/Alzheimer's disease-related dementias.

PI_NAMEs: BELSKY, DANIEL WALKER;MUENNIG, PETER A (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Age;age acceleration;age related chronic disease;Aging;aging process;aging related;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Automobile Driving;Behavioral;biobank;Biological;biological age;Biological Aging;Biological Assay;Blood;Blood Glucose;blood pressure regulation;Blood specimen;Body System;Brain;C-reactive protein;Caring;Cause of Death;Central Nervous System;Cessation of life;Chronic Disease;Cognition;Cognitive;Cognitive Science;cohort;Collaborations;Collection;Consultations;Control Groups;Crime;Data;Data Collection;Data Linkages;Data Set;dementia risk;design;Development;Diabetes Mellitus;Diet;diet and exercise;Disadvantaged;disparity elimination;disparity reduction;DNA Methylation;economic outcome;Economics;electronic data;Emotional;Employment;epigenetic clock;Executive Dysfunction;executive function;Exercise;Family;field study;follow-up;frailty;Funding;Future;Genes;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;Health Food;Health Insurance;health related quality of life;healthy aging;Height;Homeostasis;Housing;Human;Human Resources;improved;Incentives;Income;Individual;innovation;interdisciplinary approach;Intervention;intervention effect;Investigation;Laboratories;life span;Link;Loneliness;loss of function;Maintenance;Measures;Medical;Memory;Mental Depression;Mental Health;Methodology;Methods;methylation pattern;minority investigator;Moods;mortality;Motivation;National Institute on Aging;neural;Neurons;novel;nutrition;Obesity;Outcome;Outcome Assessment;Outcome Measure;Participant;Pathway interactions;patient engagement;Personal Satisfaction;Persons;Phase;physical conditioning;Population;Poverty;Premature aging syndrome;prevent;Process;programs;Psyche structure;Psychological Stress;Psychologist;Public Housing;Randomized;randomized trial;Randomized, Controlled Trials;rate of aging;Records;Research;research and development;Resources;Risk;Services;Sleep;social;Social Functioning;social health determinants;Social outcome;Social Policies;Stress;success;Surveys;System;Testing;Time;treatment group;Unemployment;United States Dept. of Health and Human Services;Weight;welfare;whole genome;Work

PROJECT_TITLE: The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: There is a critical need to expand the biomedical science workforce in order to solve problems more effectively, drive innovation, and address health disparities. Our approach to addressing this need involves a collaboration between natural and mathematical sciences, engineering, and public health. The Ohio State MARC program will train undergraduate students to conduct rigorous research from ‘molecules to society’ and at the same time engage them in community and confidence building activities with other students and biomedical researchers.

PI_NAMEs: FERKETICH, AMY K (contact);JACKMAN, JANE ELIZABETH;PRAKASH, SHAURYA

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Active Learning;Biological Sciences;Biomedical Research;career;CCL7 gene;Communities;Data;Dedications;design;Discipline;Educational process of instructing;efficacy research;Engineering;Evaluation;Faculty;Goals;graduate student;Health Sciences;improved;interest;Logic;Measurable;Mentors;Mission;Modeling;next generation;Ohio;Outcome;Paper;peer;peer support;physical science;programs;Public Health;Publishing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Science;Self Efficacy;Societies;student mentoring;Students;Training Programs;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: MARC at The Ohio State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PHR: Project Narrative: The Mississippi INBRE Community Engagement and Training Core will provide essential  outreach services to enable community-based participatory research projects with academics and community  organizations. It also offers a state-of-the-art summer program to promote students into community health-  related careers. This will be accomplished by 1) supporting community-based organizations in collaboration  with the Mississippi Center for Clinical and Translational Research, 2) Support the community-based  participatory research and outreach needs of academics, and 3) administer a summer program in the area of  community health research.

PI_NAMEs: LEMACKS, JENNIFER  (contact)

PROJECT_TERMS: Address;advanced analytics;Affect;Area;Award;Basic Science;Behavioral;Behavioral Research;Biomedical Research;Brothers;career;Chronic Disease;Cities;clinical center;Clinical Research;Clinical Trials;Collaborations;Collection;Communicable Diseases;Communication;Communities;community based participatory approach;community based participatory research;community building;community engagement;Community Health;Community Networks;community organizations;Community Outreach;Community Services;Complex;Data;Data Science Core;Deep South;Development;Disease Management;disorder prevention;Educational Curriculum;ethnic minority population;Evaluation;evidence base;experience;Faculty;Fostering;Funding;Goals;Health;health disparity;Health Professional;improved;Infrastructure;innovation;Institution;Intervention Studies;Knowledge;medically underserved;medically underserved population;member;Mentorship;Methodology;Minority;minority health disparity;Mississippi;Modeling;next generation;Outcome;outreach;outreach services;Pilot Projects;Prevalence;Primary Prevention;programs;racial minority;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Rural Population;Scholars Program;Science;Scientist;Services;Students;success;summer program;summer research;Training;training opportunity;Translating;Translational Research;translational research program;undergraduate student;underserved community;Underserved Population;Workforce Development

PROJECT_TITLE: Community Engagement and Training Core


NIH_SPENDING_CATS: Lung

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Our Program will provide M.D., M.D./Ph.D. and Ph.D. post-doctoral fellows with state-of-the-art research training in common and rare lung diseases affecting the pediatric and adult populations. Lung diseases such as lung infections including bacterial and viral pneumonia, acute respiratory distress syndrome, genetic diseases of the airways including cystic fibrosis and primary ciliary dyskinesia, chronic obstructive pulmonary disease, asthma, environmental lung diseases, and lung diseases with an environmental component such as allergic lung diseases are common and are associated with devastating morbidity, mortality and use of health care dollars. Our Program offers 48 highly qualified faculty in 7 departments to serve as mentors and co-mentors for our trainees and provides a highly multidisciplinary pulmonary scientific community that creates an outstanding opportunity for trainees to develop their technical and intellectual abilities as scientists and to become independent investigators within the national community, pursuing important questions about the pathogenesis and course of lung diseases in pediatric and adult populations and developing novel therapies.

PI_NAMEs: BOUCHER, RICHARD CHARLES;DOERSCHUK, CLAIRE M (contact);NOAH, TERRY L

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Critical Care;Research Training;Respiratory Disease;Training Programs

PROJECT_TITLE: UNC Research Training Program in Respiratory Diseases and Critical Care

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE In our first period of funding, we proposed the use of cardiopulmonary bypass as a cell delivery system in infants with CHD as a new approach for improving neurological impairments in children with CHD. We have generated critical information for bench-to-bedside translation: however, the mechanisms underlying the therapeutic action of bone marrow-derived mesenchymal stromal cells (BM-MSCs) still remain largely unknown. The overarching goal of this renewal proposal is to establish detailed molecular signatures from critical cell populations for tissue repair and regeneration at single cell resolution after BM-MSC delivery; we will then use those molecular signatures as roadmaps to identify novel molecular entities within the exosomes derived from BM-MSCs that account for the disease-modifying bioactivity in tissue injury after pediatric cardiac surgery.

PI_NAMEs: ISHIBASHI, NOBUYUKI  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Award;Behavioral;bench-to-bedside translation;Bioinformatics;Bone Marrow;Brain;Cardiac Surgery procedures;Cardiopulmonary Bypass;Cell Nucleus;Cell surface;Cell Therapy;Cells;Cerebral cortex;Child;Childhood;Chromatin;Classification;Clinical Trials;congenital heart abnormality;Data Set;Development;differential expression;Disease;Enrollment;executive function;exosome;extracellular vesicles;First Independent Research Support and Transition Awards;frontal lobe;Funding;Genetic Transcription;glial activation;Goals;Growth;Immune;Immune response;immunoregulation;Impairment;improved;Infant;Infusion procedures;Knowledge;Mediating;mesenchymal stromal cell;Messenger RNA;MicroRNAs;Mining;Molecular;Molecular Profiling;nerve stem cell;neural;Neuroglia;Neurologic;Neurological outcome;neuron apoptosis;neuron regeneration;neuroprotection;novel;novel strategies;novel therapeutics;Nuclear;Oligodendroglia;optimal treatments;Outcome;Pathology;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Phase I Clinical Trials;Play;Population;porcine model;postnatal;Postoperative Period;prevent;Process;progenitor;Publishing;Recovery;regenerative;Regulatory T-Lymphocyte;Repair Complex;repaired;Resolution;response;Role;Signal Pathway;single-cell RNA sequencing;stem;stem cells;Structure;subventricular zone;System;Testing;Therapeutic;Time;tissue injury;tissue regeneration;tissue repair;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Treatment Efficacy;unpublished works;white matter

PROJECT_TITLE: Cell Therapy for Neuroprotection in Congenital Heart Disease

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


PHR: Project Narrative: The Mississippi INBRE DRPP support biomedical research at the state's primarily  undergraduate institutes. This will be accomplished by 1) providing funds to directly support meritorious  research, 2) assist in the recruitment of outstanding researchers to their faculty, and 3) fostering professional  development and a community of researchers.

PI_NAMEs: KESSL, JACQUES J. (contact)

PROJECT_TERMS: Acceleration;Address;Administrator;Advertisements;Agreement;Award;Biomedical Research;Cancer Burden;career development;Centers of Research Excellence;college;Communicable Diseases;Communities;Contracts;Data;Dentists;design;Development;Direct Costs;Disparity;Educational process of instructing;Educational workshop;Eligibility Determination;Environment;Equipment;Equipment and Supplies;Exercise;experience;experimental study;Extramural Activities;Faculty;Faculty Recruitment;faculty research;faculty support;Feedback;Fostering;Funding;Funding Mechanisms;Future;Generations;Goals;Grant;hands on research;Health;human capital;improved;Individual;Infrastructure;Institution;interest;Laboratories;Leadership;Malignant Neoplasms;meetings;member;Mentors;Minority-Serving Institution;Mission;Mississippi;Modeling;Obesity;online course;Outcome;peer;Peer Review;Performance;Persons;Physicians;Positioning Attribute;Process;Productivity;Program Research Project Grants;programs;Publications;Qualifying;recruit;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Rotation;Schedule;STEM field;student participation;student training;Students;success;Surveys;symposium;Talents;teacher;tenure track;Time;Training;undergraduate research;undergraduate research experience;undergraduate student;virtual;Visit;Work

PROJECT_TITLE: Developmental Research Project Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PI: Buelow, Hannes E.  Project Relevance  Nerve cells receive their input by way of elaborately branched structures termed dendrites, which are defective in numerous neuropathological conditions such as certain forms of mental retardation or autism spectrum disorders. While significant progress has been made in regard to many aspects of neural development, much remains to be learned about basic aspects of dendrite development. Here we propose to investigate novel mechanisms of dendrite development using a combination of C. elegans molecular, genetic, imaging and biochemical approaches.

PI_NAMEs: BUELOW, HANNES ERICH (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Actins;Afferent Neurons;Aging;Alleles;Animals;autism spectrum disorder;Axon;axon guidance;Behavior;Binding Proteins;Binding Sites;Biochemical;Biological Process;Bipolar Neuron;Caenorhabditis elegans;Cell Adhesion Molecules;Cell Death;Cell Physiology;Cell Surface Receptors;Cells;Complex;Cytoskeleton;Defect;Dendrites;design;Development;E2F transcription factors;Enhancers;Ensure;Environment;Epidermis;Genes;Genetic;genetic analysis;genetic approach;genetic regulatory protein;Genetic Screening;Guanosine Triphosphate Phosphohydrolases;human disease;Image;insight;Learning;Link;loss of function;Maps;Mediating;Mental Retardation;Microtubules;Mitogen-Activated Protein Kinases;Modality;model organism;Molecular;Morphogenesis;mutant;Mutation;Nematoda;neural circuit;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropathology;neuropsychiatric disorder;novel;Organism;Output;Pathway interactions;Pattern;Phenotype;postmitotic;Posture;Process;programs;Proprotein Convertases;receptive field;Research;Sampling;Sensory;sensory input;Shapes;Signal Transduction;Skin;somatosensory;Stimulus;Structure;Suppressor Mutations;Surface;Synapses;transcription factor;transmission process;Trees;Work

PROJECT_TITLE: Genetic Analyses of Dendrite Morphogenesis in Caenorhabditis Elegans

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE NDPP-NextGen has high potential impact via dissemination among >1700 organizations that deliver the NDPP. If successful, future directions include following offspring to assess continued effects on childhood health outcomes, and help assure potential health benefits for generations to come.

PI_NAMEs: RITCHIE, NATALIE DAWN;SAUDER, KATHERINE A. (contact)

PROJECT_TERMS: Adult;adverse maternal outcomes;Affect;aged;Air;behavioral outcome;Birth;Body mass index;Body Weight decreased;Childhood;Clinical;Clinical Trials;comparison control;Conceptions;Contraceptive methods;Contraceptive Usage;critical period;Data;Diabetes Mellitus;diabetes prevention program;diabetes risk;Diet;Disease;early pregnancy;Electronic Health Record;Eligibility Determination;Enrollment;ethnic minority;Exclusion;Exposure to;Family Planning;fasting glucose;Future;Generations;Gestational Age;Gestational Diabetes;gestational weight gain;Health;Health Benefit;High Prevalence;Home;implementation science;improved;Infant;Influentials;Intention;intergenerational;Intervention;lifestyle intervention;Low income;Maternal and Child Health;maternal outcome;Measures;Mediation;Motivation;neonate;newborn adiposity;Obesity;obesity risk;offspring;Outcome;outreach;Overweight;Participant;Persons;Plethysmography;Pre-Eclampsia;Pregnancy;pregnancy hypertension;pregnant;prenatal;primary outcome;racial minority;Randomized;Randomized, Controlled Trials;recruit;remote delivery;Research;Resources;Risk;Safety;Sampling;scale up;screening;secondary outcome;Self Efficacy;Small for Gestational Age Infant;Smoking;transmission process;treatment as usual;usual care arm;Woman;young woman

PROJECT_TITLE: NDPP-NextGen: A clinical trial to reduce intergenerational obesity and diabetes risks

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: MANHASSET

ORG_NAME: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH

PHR: PROJECT NARRATIVE Loneliness is associated with a 26% increased risk of mortality and morbidities including heart attack, stroke, depression, anxiety, distress, and pain. The current research proposes to reduce loneliness in care partners of persons with Alzheimer’s Disease (AD) and AD-related dementias through increasing care partners’ sense of meaning and purpose in life with concepts from Meaning-Centered Psychotherapy, delivered via a web-based platform. Through effectively addressing loneliness, and decreasing the likelihood of the negative health outcomes with which loneliness is associated, this work has high potential to reduce the burden of age-related disease, consistent with the National Institute on Aging’s strategic direction over the next 5 years.

PI_NAMEs: MARZILIANO, ALLISON  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;age-related disease;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Anxiety;Burn injury;cancer care;career;Caring;Consent;dementia care;design;Disease;Distress;Doctor of Philosophy;Dropout;Education;effective intervention;Evidence based intervention;Exercise;experience;Feedback;Feeling;Focus Groups;Future;Genetic Transcription;Goals;Group Meetings;Group Psychotherapy;Health;improved;Individual;innovation;Instruction;Intervention;intervention delivery;Interview;Learning;Life;Link;Loneliness;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Meaning and purpose;meetings;member;Mental Depression;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality risk;Myocardial Infarction;National Institute on Aging;older adult;Outcome;Pain;Participant;Patients;Persons;Phase;Population;programs;Psyche structure;Psychotherapy;Public Health;Published Comment;Randomized;Reading;Reporting;Research;Research Design;Research Personnel;Social Workers;statistics;Stroke;success;Suggestion;System;Technology;Testing;Theoretical model;Thinking;Training;treatment arm;treatment as usual;usability;Vertebral column;Video Recording;virtual group;web platform;web-based intervention;Work;Writing

PROJECT_TITLE: Increasing Meaning to Reduce Loneliness in Care Partners of Persons with AD/ADRD

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Pediatric;Prescription Drug Misuse;Prevention;Primary Health Care;Stimulant Use and Misuse;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Narrative Non-prescribed use, for cognitive enhancement (e.g., while studying) or recreation (e.g., partying), of stimulant medications by young adults is a prevalent problem; this Schedule II controlled medication is usually obtained from peers with prescriptions, yet little data are available to explain this diversion behavior. Efforts to prevent stimulant misuse are therefore missing key information. The proposed research will study diversion behavior among young adults with ADHD and its longitudinal predictors to improve the prevention of stimulant misuse and its associated adverse medical and legal consequences.

PI_NAMEs: MOLINA, BROOKE S.G. (contact)

PROGRAM_OFFICER_NAME: KURAMOTO-CRAWFORD, SATOKO JANET

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Age;Aging;Area;Attention deficit hyperactivity disorder;Attitude;Behavior;Behavioral;behavioral economics;Child Rearing;Childhood;cognitive enhancement;common treatment;Cross-Sectional Studies;Data;Decision Making;Development;Diagnosis;Disclosure;discounting;Distal;Drug Prescriptions;emerging adult;Environment;Formulation;improved;Impulsivity;Intention;Legal;Medical;National Institute of Drug Abuse;parental involvement;Parents;Pathway interactions;Patients;pediatrician;peer;Persons;Pharmaceutical Preparations;Policies;Population;Prevalence;prevent;Prevention;Primary Care;prospective;Prospective Studies;Provider;provider factors;Published Comment;Race;Recreation;recruit;Reporting;Research;Risk;Risk Factors;Role;Sampling;Schedule;Science;sex;social;socioenvironmental factor;Stimulant;stimulant misuse;Strategic Planning;Time;trend;willingness;young adult

PROJECT_TITLE: A prospective examination of stimulant diversion and related risk factors for young adults with childhood- or adult-diagnosed ADHD

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Recent information indicates that the health of fathers can influence the health of his offspring, via nongenetic (epigenetic) mechanisms. In this proposal, we will use a mouse model to test the hypothesis that paternal obesity and hyperglycemia can modify epigenetic marks in the sperm, and that these changes in sperm affect early life development and ultimately increase disease risk in offspring. Moreover, we will test whether using medications or dietary strategies to lower body weight and glucose in the father can improve health of offspring, and identify the mechanisms responsible for such changes.

PI_NAMEs: PATTI, MARY E (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: adenylate kinase;Adult;Adult Children;Affect;age related;Bile Acids;Binding Sites;bisulfite sequencing;blastocyst;Body Weight;Breeding;burden of illness;Caloric Restriction;cdc Genes;Cell Cycle Regulation;Cell Nucleus;Cell Respiration;Cells;Conceptions;Data;Development;Diabetes Mellitus;dietary;differential expression;disorder risk;DNA;DNA Methylation;Educational Intervention;Elements;Embryo;embryo tissue;Enhancers;Environment;Epigenetic Process;epigenetic regulation;epigenome;exercise training;Exposure to;Fasting;Fathers;Fatty Liver;Fertilization in Vitro;fetal;Funding;Future Generations;Gene Expression;Gene Expression Profiling;Generations;Genes;Genetic;Genetic Transcription;Germ Cells;Glucose;Glucose Intolerance;Health;Human;Hyperglycemia;improved;in vivo;inhibitor;Injections;innovation;Insulin Resistance;intergenerational;Interruption;Intervention;Knockout Mice;Life;Life Cycle Stages;Link;lipid metabolism;Lipids;Liver;male;Malnutrition;Mediating;Mediator;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic syndrome;Metabolism;Modeling;molecular phenotype;Mothers;mouse model;Mus;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Nutritional;Obesity;offspring;Outcome;Parents;Pathogenicity;Pathway interactions;Pharmaceutical Preparations;Phenotype;Placenta;Placentation;Population;Pregnancy;programs;promoter;Public Health;Regulator Genes;Resistance;response;Risk;Small RNA;Somatic Cell;sperm cell;Testing;Therapeutic Intervention;Tissues;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;transmission process;Umbilical Cord Blood;Weight Gain;Work

PROJECT_TITLE: Paternal Contributions to Metabolic Disease in Offspring:  Environment, Epigenetics, and Sperm

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Alzheimer's disease (AD) is the most common form of dementia and commonly affects older adults. The proposed research focuses on the early prediction of AD and the identification of potentially new AD biomarkers in tear, saliva, and blood by developing a novel multimodal biosensing platform enhanced by artificial intelligence techniques. Thus, this proposal is related to the mission of NIA that is to improve the health and well-being of older adults through scientific and innovative research.

PI_NAMEs: HU, JUEJUN ;MA, FENGLONG  (contact);ZHANG, CAN MARTIN

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Academia;Address;Affect;Algorithmic Software;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Amyloid Proteins;analytical tool;apolipoprotein E-4;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;Binding;Biological Markers;biomarker discovery;biomarker identification;Biosensing Techniques;Biosensor;Blood;Body Fluids;cantilever;Cessation of life;Collaborations;cost;Data;data repository;Data Scientist;deep learning algorithm;Dementia;design;design verification;Detection;detection method;detection platform;Devices;Drug Industry;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Feedback;flexibility;General Hospitals;Goals;Health;health care service organization;heterogenous data;Human;Immunohistochemistry;Impaired cognition;improved;innovation;insight;Interdisciplinary Study;Knowledge;Learning;Machine Learning;machine learning framework;machine learning method;Magnetic Resonance Imaging;Mass Spectrum Analysis;Massachusetts;Measures;Mechanics;medical schools;Memory;Methods;minimally invasive;Mining;Mission;Modality;Modeling;multimodal learning;multimodality;nanosensors;Nanotechnology;Neurodegenerative Disorders;novel;older adult;optical fiber;Optics;Output;Patients;Performance;Personal Satisfaction;Personality;photonics;Positioning Attribute;programs;Raman Spectrum Analysis;Research;Research Personnel;Saliva;Scientist;Sensitivity and Specificity;sensor;Signal Transduction;Software Tools;Somatotype;Source Code;specific biomarkers;Statistical Data Interpretation;System;tau Proteins;Techniques;tomography;Training;two-dimensional;waveguide;Weight;Western Blotting;Work

PROJECT_TITLE: SCH: AI-Enhanced Multimodal Sensor-on-a-chip for Alzheimer's Disease Detection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative One major hope for diabetes therapy is to generate a large number of functional, transplantable β-cells from patient-derived human pluripotent cells (hPSCs) in vitro, but current protocols still lack consistency between different hPSC lines. Here we propose to use cutting-edge single-cell genomic technologies to characterize the individual variations between many hPSC lines at molecular level. This study will lead to better understanding about the disease causes and novel therapeutic opportunities.

PI_NAMEs: JIN, FULAI ;LI, YAN  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Beta Cell;Biological Assay;blood glucose regulation;Cell Differentiation process;Cell Line;Cell Lineage;Cells;Chromatin;cost;CRISPR screen;Data;data resource;data sharing;data visualization;Development;Diabetes Mellitus;diabetes mellitus therapy;differentiation protocol;Disease;endodermal progenitor;Enhancers;Ensure;Epigenetic Process;epigenetic variation;epigenome;Ethics;Etiology;experimental study;Fetus;gain of function;Genes;Genetic Diseases;Genetic Variation;Genome;genome editing;genome wide association study;Genomic approach;Genomics;Goals;Hi-C;Human;human embryonic stem cell;human pluripotent stem cell;improved;In Vitro;in vivo;Individual;individual variation;induced pluripotent stem cell;innovation;insight;Intuition;islet;Lead;Legal;loss of function;Maps;Metabolic;Metabolism;Methods;Mitochondrial DNA;Modeling;Molecular;Mus;Names;Nature;novel therapeutics;Obesity;Pancreas;pancreas development;Patients;Physiological;Population;prevent;promoter;Protocols documentation;Publishing;Reporting;Research;Resolution;risk variant;Series;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Sorting;SOX17 gene;stem cells;Structure of beta Cell of islet;System;TCF7L2 gene;Technology;Therapeutic;Time;Tissues;tool;trait;transcriptome;Transplantation;Untranslated RNA;Variant;Visualization software;web site;Work

PROJECT_TITLE: Understanding the variation of induced β-cell differentiation.

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Neurosciences;Women's Health Research

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Many neurological conditions, including neurodegenerative diseases, and mental illnesses present with prominent alterations of social interactions that reflect malfunctioning of core neural circuits. Our project focuses on characterizing a small set of neurons located in a complex deep brain center that regulates many core functions, including defense from predators, social and emotional behaviors, satiety, and neuroendocrine control. Our research will shed light on how these neurons might regulate social behaviors in health, and it has the potential to provide insights into interventions that aid diagnosis or ameliorate symptoms of altered social behaviors in disease states.

PI_NAMEs: SHAH, NIRAO MAHESH (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Aggressive behavior;Anxiety;Behavior;Behavior Control;behavior test;Behavioral;Biological;Brain;Case Study;cell type;Clinical;Communication;Complex;Courtship;deep sequencing;Development;Diagnosis;Disease;Dissection;emotional behavior;ESR1 gene;Estrogen Receptors;Female;Fiber;Functional disorder;G-Protein-Coupled Receptors;Gene Expression Profile;genetic approach;Genetic Transcription;Goals;Halorhodopsins;Health;Heterogeneity;Hypothalamic structure;Image;Individual;insight;interest;Intervention;Knowledge;Language;Lesion;Light;Link;Major Depressive Disorder;male;Maps;Maternal Behavior;mating behavior;Mental disorders;Modernization;Molecular;Mouse Strains;Mus;Nerve Degeneration;neural circuit;Neural Pathways;Neurodegenerative Disorders;Neurologic;Neurons;Neurosciences;Neurosecretory Systems;non-verbal;novel;optogenetics;Output;Partner in relationship;Pathway interactions;Performance;Phenotype;Photometry;Population;Progesterone Receptors;reduce symptoms;Reporter;reproductive success;Research;Role;Sampling;Satiation;sex;Sex Bias;Sex Differences;sexual dimorphism;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Social Behavior;Social Controls;Social Interaction;Specific qualifier value;Specificity;Symptoms;Testing;Tracer;transcriptomics;vector;Viral;Well in self;Work

PROJECT_TITLE: Functional dissection of a molecularly identified female-specific neural pathway in mice

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Patient Safety;Physical Activity;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Type 2 diabetes is typically managed by steadily escalating pharmacotherapy to keep pace with disease progression. GEM is an alternative intervention that could help some people prevent this cycle by empowering them to significantly improve their overall health, capitalize on GEM’s positive psychological benefits, and manage their diabetes with no or less medication. Because there are more than 1.6 million new cases of Type 2 Diabetes in the U.S. every year that contribute to individual morbidity and mortality and the 327 billion dollar annual cost of the disease, GEM could diminish this burden on the health care system and save millions of dollars annually, while reducing misery among patients and their families.

PI_NAMEs: COX, DANIEL JOSEPH;FABRIS, CHIARA  (contact);OSER, TAMARA K

PROJECT_TERMS: Adherence;Adipose tissue;Adult;Aftercare;Algorithms;Alternative Therapies;American;Area Under Curve;Behavioral;Blood capillaries;Blood Glucose;blood glucose regulation;Blood Pressure;Body mass index;Body Weight decreased;Calories;Carbohydrates;cardiovascular disorder risk;cardiovascular risk factor;Clinical;Complex;Consent;cost;cost effective;Cost of Illness;depressive symptoms;diabetes distress;diabetes management;Diabetes Mellitus;diaries;Diet;diet and exercise;Disease Progression;Dose;Economics;effective therapy;efficacy evaluation;empowerment;Epidemic;Expenditure;Family;Fatty acid glycerol esters;Feedback;Glucose;glucose monitor;Glycosylated hemoglobin A;Grant;Health;Health Benefit;Healthcare Systems;High Density Lipoproteins;Home;Hyperglycemia;improved;Individual;Individual Differences;Ingestion;Injectable;innovation;Insulin;Insulin Resistance;Intake;Internet;Intervention;Learning;Life Style Modification;lifestyle intervention;Lipids;Liver;Maintenance;Manuals;medication compliance;Medication Management;Mental Depression;Metabolic Control;Metformin;Modification;Morbidity - disease rate;mortality;Multicenter Studies;Newly Diagnosed;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;optimal treatments;Oral;Outcome;Pancreas;pandemic disease;Parents;Participant;Patient Preferences;Patients;personalized management;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Physical activity;Physiological;Pilot Projects;preference;prevent;primary care provider;Production;programs;psychologic;psychosocial;Public Health;Randomized;Reading;Recommendation;Recovery;Regimen;Reporting;Research;Research Personnel;Resources;routine care;Self Administration;Severity of illness;side effect;Skeletal Muscle;skills;social;Standardization;success;Text;Text Messaging;Time;Toxic effect;treatment optimization;trial design;user-friendly;Weight;weight loss intervention;Work

PROJECT_TITLE: Treating early type 2 diabetes by reducing postprandial glucose excursions: A paradigm shift in lifestyle modification


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Project Narrative This project empirically examines novel predictions about harmful extinction bursts, which are poorly understood and impede treatment success with many behavior disorders. It seeks to fill existing gaps in basic/theoretical knowledge about extinction bursts through a rare and close collaboration between basic and clinical scientists. The project closely aligns basic and clinical research to increase the clinical relevance of basic studies, which in turn should lead to more effective clinical treatment of extinction bursts.

PI_NAMEs: FISHER, WAYNE WILLIAM (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TITLE: Basic and applied research on extinction bursts when treating problem behavior

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]