NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Rural Health;Substance Misuse;Telehealth

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The proposed study will adapt an evidence-based mobile health (mHealth) intervention to reduce overdose risk behavior among people who use drugs (PWUD). We will pilot the adapted intervention and then conduct a randomized controlled trial to evaluate its efficacy, along with qualitative interviews to understand participants’ experiences of the intervention. We will conduct this research in partnership with the National Harm Reduction Coalition, PWUD, and local harm reduction service providers using a generative co-design process so that the potentially lifesaving OD prevention intervention will be usable and feasible in real-world settings.

PI_NAMEs: LORVICK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: addiction;Address;Adherence;Alcohols;Attenuated;attenuation;Benzodiazepines;California;Cellular Phone;Central Nervous System Depressants;Cessation of life;Characteristics;Collaborations;Communication;community setting;Data Collection;data integration;design;Disease;Drug Combinations;Drug user;Ecological momentary assessment;efficacy evaluation;Epidemic;evidence base;experience;Fentanyl;Friends;Future;Goals;Harm Reduction;Health education;Helping to End Addiction Long-term;high risk drinking;Hour;improved;innovation;Intervention;intervention effect;Interview;Knowledge;Learning;Life;Literature;Measures;Methamphetamine;Methods;mHealth;mhealth interventions;Modality;Modeling;Modification;Motivation;Opiate Addiction;Opioid;opioid misuse;Outcome;Overdose;overdose death;overdose prevention;Overdose reduction;overdose risk;overdose risk behaviors;Participant;Pattern;Persons;Phase;Pilot Projects;polysubstance use;post intervention;preventive intervention;Process;Provider;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Research;Risk;rural environment;service providers;smartphone application;Speed;Stimulant;Structure;substance use;Substance Use Disorder;Support System;Testing;Treatment Efficacy;United States National Institutes of Health;urban setting;usability

PROJECT_TITLE: "A friend in my pocket": mHealth intervention to reduce overdose risk among people who engage in polysubstance use

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SKP-E (M2)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Encinitas

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: PERCEPTION DYNAMICS INSTITUTE

ORG_STATE: CA

PHR: This study seeks to address the challenge of how to deliver targeted interventions that address the individualized cognitive needs of mild traumatic brain injury (mTBI) patients. The overall objective of our predicate SBIR Phase I grant that started in July 2023 is to determine the feasibility of a timing intervention (PATH neurotraining) to significantly improve visual working memory, processing speed (primary outcomes) and auditory working memory, selective attention, cognitive flexibility, sustained attention, reading speed, and reading proficiency (secondary outcomes) in mTBI patients more than after either Sham or conventional N-Back Working Memory training (Aim 1). The challenge is to: 1) have PATH neurotraining be distributed by centers aimed at cognitive remediation for mTBI patients, such as neurologists, rehab centers, and learning centers, which can only be done after this clinical trial is completed, and 2) increase awareness of our clinical trials research so that PATH neurotraining will be accepted as a proven method for remediating cognitive skills after a concussion.

PI_NAMEs: LAWTON, TERI A (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Address;Age;age group;Area;Attention;attentional control;Auditory;Awareness;Back;Behavioral;Biological Markers;Brain Concussion;Brain imaging;Clinical Trials;Cognitive;cognitive ability;cognitive control;Cognitive deficits;Cognitive remediation;cognitive skill;cognitive testing;cognitive training;Data;design;dorsal visual stream;Educational Intervention;Etiology;executive function;flexibility;Grant;improved;Individual;Individual Differences;Intervention;Learning;Magnetoencephalography;Memory;Methods;mild traumatic brain injury;neural correlate;Neural Pathways;Neurologist;Neuropsychological Tests;Outcome;Participant;Pathway interactions;Patients;Phase;primary outcome;processing speed;Reading;reading ability;Research;secondary outcome;selective attention;Short-Term Memory;Small Business Innovation Research Grant;Speed;Standardization;sustained attention;TBI Patients;Testing;theories;Training;Veterans;Video Games;Vision;Visual;visual control;Work

PROJECT_TITLE: Retraining Neural Pathways to Improve Cognitive Skills after a Mild Traumatic Brain Injury (mTBI)


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Multiple Sclerosis;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative T2* mapping and quantitative susceptibility mapping (QSM) are critical MRI techniques for in vivo iron quantification, providing crucial information about brain development and neurodegenerative diseases, including Multiple Sclerosis (MS). However, T2* and QSM have yet to be widely adopted in clinical practices due to long scan time and sensitivity to motion and B0 fluctuations. This work aims to develop and validate a motion- and B0- robust technique for T2* and QSM quantification using the spherical echo planar time-resolved imaging (sEPTI), deep learning-based image reconstruction, prospective motion correction, and retrospective B0 correction, which will significantly improve the image quality and accessibility of T2* and QSM and widen their clinical and scientific applicability in general populations.

PI_NAMEs: WANG, NAN  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 1 year old;3-Dimensional;Acceleration;Adopted;Brain;bulk motion;Characteristics;Charge;Childhood;Clinical;clinical application;clinical practice;cognitive disability;Data;deep learning;denoising;Development;Elderly;General Population;Goals;Head Movements;Human;Image;Image Enhancement;image reconstruction;Imaging Techniques;improved;in vivo;Infant;interest;Iron;learning network;Lesion;Magnetic Resonance Imaging;Maps;millimeter;Morphologic artifacts;Motion;Multiple Sclerosis;multiple sclerosis patient;Neurodegenerative Disorders;novel strategies;Outcome;Pathologic;Pathologic Processes;Pathology;Patients;Phase;physically handicapped;Physiological;Physiological Processes;Population;Predisposition;prospective;Protocols documentation;reconstruction;Resolution;Sampling;Scanning;Scheme;Severity of illness;Signal Transduction;spatiotemporal;System;T2 weighted imaging;Techniques;Time;Tissues;Training;Translating;Work

PROJECT_TITLE: Fast and robust quantitative MRI with tissue-susceptibility mapping of the human brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-E (M1)]


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: ITHACA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Distinct groups of eukaryotic DNA mismatch repair (MMR) family proteins facilitate crossing over between homologs to ensure proper Meiosis I chromosome segregation, and act to prevent recombination between divergent DNA sequences that can lead to chromosomal rearrangements associated with diseases such as cancer. In humans, failures in meiotic chromosome segregation result in aneuploidy syndromes (at least 10% of human pregnancies), which are thought to occur as the result of Meiosis I and II errors, defective or inappropriate recombination, premature homolog separation, and defects in sister chromatid cohesion. Importantly, mutations in MMR genes have been found in about half of hereditary non-polyposis colorectal cancer (2-7% of all colon cancers) patients, and are thought be linked to infertility, underscoring the importance of obtaining new mechanistic understandings and molecular tools to establish allele pathogenicity.

PI_NAMEs: ALANI, ERIC E. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Affect;Alleles;Aneuploidy;base;Binding;Biochemical;Bypass;Chromosomal Rearrangement;Chromosome Segregation;cohesion;Colon Carcinoma;Complex;Cruciform DNA;Deacetylase;Defect;Diffusion;Dimerization;Disease;DNA;DNA biosynthesis;DNA Sequence;endonuclease;Ensure;Eukaryota;Failure;Filament;gene repair;Genetic;Genetic Crossing Over;Genetic Recombination;Genome Stability;genome wide screen;Grant;helicase;Hereditary Nonpolyposis Colorectal Neoplasms;Histones;Homologous Gene;homologous recombination;Human;Hydrolysis;In Vitro;Infertility;Inherited;insertion/deletion mutation;Invaded;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Meiosis;Meiotic Recombination;Methods;Mismatch Repair;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular modeling;mutant;Mutation;nuclease;Pathogenicity;Pathway interactions;Patients;Pregnancy;premature;prevent;Protein Family;Proteins;Reaction;reconstitution;recruit;repaired;Research;Role;Saccharomyces cerevisiae;single molecule;Sister Chromatid;Site;Specificity;Syndrome;System;Testing;tool;Topoisomerase;Work

PROJECT_TITLE: Roles for Mismatch Repair Proteins in Maintaining Genome Stability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: Princeton

ORG_DEPT: NEUROSCIENCES

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative Gonadal hormones profoundly influence social behavior and many psychiatric disorders associated with social dysfunction, such as depression and anxiety disorders; some social behaviors, such as self-initiated (“proactive”) behaviors can promote resiliency to these disorders. Despite this, we lack a clear understanding of how gonadal hormones shape network scale neural coding of the social environment and proactive behavior at a moment-to- moment level. Here, I develop new technology to probe the effect of hormonal change on “proactive” social behavior and its encoding by a multi-brain region network of neural circuits, building an experimental framework for future studies on the relationship between hormones, self-initiated behavior, and resilience.

PI_NAMEs: GUTHMAN, EARTHA MAE (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Affect;Anxiety;Anxiety Disorders;Behavior;behavior change;Behavioral;Brain;Brain region;Calcium;Code;Color;Complex;computational neuroscience;Computer Analysis;computerized tools;Computing Methodologies;deep learning;Development;Disease;Etiology;Exhibits;experience;experimental study;Feedback;Functional disorder;Future;gender difference;Gene Expression;Genetic Transcription;Goals;Gonadal Hormones;Hormonal;Hormonal Change;Hormones;in vivo;Individual;insight;interest;Laboratories;Maps;Mediating;Mental Depression;Mental disorders;Mentors;Mentorship;Mood Disorders;Mus;neural;neural circuit;Neuroendocrinology;Neurons;Neurophysiology - biologic function;Neurosciences;Neurosecretory Systems;new technology;novel;Optics;Outcome;outcome prediction;Phase;Play;Population;programs;promote resilience;receptor;Reporter;Research;Research Training;resilience;Role;sex;Sex Differences;Shapes;Site;skills;social;Social Behavior;social deficits;Social Environment;social influence;Social Interaction;spatiotemporal;success;System;Techniques;Testing;Time;tool;Training;Training Programs;Work

PROJECT_TITLE: Mapping Neural Dynamics in Hormone-sensitive Networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Orphan Drug;Pediatric;Pediatric Cancer;Pulmonary Fibrosis;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Between 2016-2020, over 12,000 hematopoietic cell transplants (HCT) were performed in children in the United States as treatment for cancers, immunodeficiencies, blood disorders, and other life-threatening diseases. After HCT, injury to the lung due to infections, chemotherapy, or inflammation can lead to a type of scarring called pulmonary fibrosis that affects quality of life and leads to premature death. As pulmonary fibrosis is challenging to diagnose but potentially treatable, this proposal aims to develop respiratory and blood-based screening tools that can identify patients with or at-risk for pulmonary fibrosis who may benefit from novel treatment strategies.

PI_NAMEs: ZINTER, MATTHEW SCOTT (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Ablation;Acute;acute infection;Address;Affect;Age;Allogenic;Allografting;Alveolar;Alveolar Macrophages;antifibrotic treatment;Biological;biological sex;Biology;Biopsy;Blood;Blood specimen;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;cancer therapy;Cessation of life;chemoradiation;chemotherapy;Chest imaging;Child;Childhood;Chronic;Cicatrix;Clinical;cohort;Collagen;Data;Defect;Deposition;Development;Diagnosis;Diffusion;Disease;Dose;Early identification;Epithelial Cells;epithelial injury;Epithelium;Fibroblasts;fibrogenesis;Fibrosis;functional decline;Future;Gene Expression;Gene Expression Profile;Genes;Goals;Grant;hazard;Hematological Disease;Hematopoietic;Hematopoietic Stem Cell Transplantation;Herpesviridae;High Dose Chemotherapy;high risk;high risk population;Histologic;Histology;Hospital Mortality;Hyperplasia;Hypoxia;immune reconstitution;immunodeficiency;Impairment;improved;Infection;Inflammation;Injury;insight;Intention;interstitial;Intervention Trial;Intravenous infusion procedures;Investigation;isoimmunity;Life;Link;Lung;lung injury;Malignant - descriptor;Malignant Neoplasms;Marrow;Mass Spectrum Analysis;Matrix Metalloproteinases;Measures;Mesenchymal;Molecular;Molecular Profiling;monocyte;Morbidity - disease rate;mortality risk;National Heart, Lung, and Blood Institute;Non-Malignant;novel;Outcome;Pathway interactions;Patient Selection;Patients;Pediatric cohort;Phenotype;Physiology;Population;premature;Premature Mortality;Process;Production;Proteins;proteomic signature;Proteomics;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Pulmonary Inflammation;Quality of life;Radiation Toxicity;radiological imaging;recurrent infection;research clinical testing;respiratory;Risk;Safety;Sampling;Screening procedure;Signal Transduction;Survivors;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;therapy design;Time;Toxicity due to chemotherapy;transcriptomics;Transforming Growth Factor beta;Transplant Recipients;transplant survivor;Transplantation Conditioning;treatment strategy;United States;Up-Regulation;Work

PROJECT_TITLE: Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Mutations in chromatin regulators are a major cause of neurodevelopmental disorders. While these chromatin-linked neurodevelopmental disorders display misexpression of sperm and ovary genes in the brain, the mechanisms and impact of such gene misregulation remain unknown. The proposed research aims to determine whether such germline gene expression in the brain impacts brain development and behavior, thereby identifiying therapeutic targets of neurodevelopmental disorders.

PI_NAMEs: IWASE, SHIGEKI  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Ablation;Address;Aggressive behavior;autism spectrum disorder;autism symptoms;Behavior;Behavioral;behavioral phenotyping;Biology;Brain;brain tissue;Cells;Cellularity;Chromatin;Chromatin Structure;Chromosomes;Data;Defect;derepression;Development;Disease;disease model;DNMT3B gene;Drug Targeting;Ectopic Expression;Embryo;Foundations;functional genomics;Future;gene discovery;Gene Expression;Gene Silencing;Genes;Genetic;Genetic Transcription;Genomic approach;Genomic Imprinting;Germ Cells;Germ Lines;Goals;Human;Impairment;imprint;innovation;Intellectual functioning disability;Knock-out;Knockout Mice;Knowledge;Lead;Lesion;Link;loss of function;Lysine;Meiosis;Methyl-CpG-Binding Protein 2;Methylation;Modification;Molecular;mouse model;mutant;Mutant Strains Mice;Mutation;Names;neurodevelopment;Neurodevelopmental Disorder;Neurologic;next generation;Ovary;Patients;Pharmaceutical Preparations;Phenotype;piRNA;prevent;programs;Proteins;Research;Schizophrenia;Somatic Cell;sperm cell;stem cells;Surveys;Synapses;Synaptic plasticity;Testing;Testis;Therapeutic;therapeutic target;Time;trait;transcriptome;transcriptome sequencing;Work;Yeasts

PROJECT_TITLE: Soma-to-germline Transformation in Neurodevelopmental Disorders?

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because understanding the mechanisms behind vascular stabilization during embryogenesis is vital to preventing vascular birth defects, which are too often fatal. The goal of this research is to investigate the role of endothelial primary cilia as mechanosensitive signaling structures in vascular development and stabilization, which will have an impact on how new approaches are developed to manage and prevent vascular birth defects such as arteriovenous malformations, aneurysms, and congenital defects of the heart and great vessels.

PI_NAMEs: WILSON-COLIJN, SARAH ANN (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: 3-Dimensional;Aneurysm;Animal Model;Arteriovenous malformation;Biology;Blood flow;Blood Vessels;cardiovascular health;Cardiovascular system;Cell Culture Techniques;Cell Physiology;Cells;Cilia;ciliopathy;cilium biogenesis;Circulation;cohort;Confocal Microscopy;Congenital Abnormality;Congenital Cardiovascular Abnormality;Congenital Heart Defects;Data;Data Set;Defect;Development;Electron Microscopy;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Enrollment;Event;Extravasation;fetal;Fishes;Fortification;Future;Gene Expression;Gene Mutation;Genes;Genetic study;Genetic Transcription;genetic variant;Goals;hemodynamics;Hemorrhage;Human;Image;Impairment;In Vitro;in vitro Assay;in vivo;innovation;insight;Link;mechanotransduction;Modeling;Morphology;Mus;mutant;Mutation;novel;novel strategies;offspring;Organism;Parents;Patients;Pediatric Cardiac Genomics Consortium;Phase;Phenotype;Play;prevent;Process;Proteins;Public Health;recruit;Research;response;Role;Rupture;shear stress;Signal Transduction;stem;Structure;Testing;Variant;Work;Zebrafish

PROJECT_TITLE: Primary cilia as regulators of vascular stability during embryonic development

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (MA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Narrative We have identified a relatively unexplored aspect of neuroinflammation with aging and Alzheimer’s disease characterized by microglial upregulation of the Major Histocompatibility Complex I (MHC-I) and paired immunoglobulin receptor families (Lilrs and Pilrs). This pathway could cell-autonomously regulate microglial phenotype with aging and Alzheimer’s disease in addition to canonical interactions with T cells. MHC-I will be suppressed specifically in microglia to assess the effects on microglial phenotype/function and T cell recruitment and phenotype with aging and Alzheimer’s.

PI_NAMEs: FREEMAN, WILLARD M (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Ablation;adaptive immunity;Adult;Age;Age of Onset;age related;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease model;Anti-Inflammatory Agents;Antigens;Biochemical;Brain;brain health;brain parenchyma;Cells;cognitive function;comparison control;design;Development;Disease;Elderly;Family;Gliosis;Human;Immune;Immune system;immunoglobulin receptor;Immunoglobulins;Inflammaging;Inflammation;Inflammatory;ITAM;ITIM;Knock-in;Knock-out;Leukocytes;LoxP-flanked allele;Macrophage;Major Histocompatibility Complex;Measures;Methods;Microglia;Modeling;Modernization;Molecular;molecular phenotype;Morphology;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroimmune;neuroinflammation;neuropathology;novel;old mice;Pathway interactions;Patients;Phagocytes;Phagocytosis;Phenotype;prevent;prodromal Alzheimer's disease;Proliferating;Proteins;Proteomics;receptor;recruit;Regulation;Reporting;Reproducibility of Results;Research;response;Senile Plaques;Signal Transduction;Speed;Sterility;symposium;Symptoms;T cell infiltration;T-Cell Receptor;T-Lymphocyte;Techniques;Testing;Time;Transcript;Transgenic Organisms;Tyrosine;Up-Regulation;Validation;Virus;Virus Diseases

PROJECT_TITLE: Major Histocompatibility Complex I regulation of microglial function in aging and Alzheimer's Disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Data Science;Dementia;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Osteoporosis;Precision Medicine;Prevention;Sleep Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Consolidated sleep is crucial for older individuals' cognition, health, and well-being, but the fragmentation of sleep and wake increases with age. This study will investigate underlying mechanisms contributing to sleep- wake fragmentation and explore the utility of a novel intervention, afternoon phototherapy, to reduce the consequences of sleep-wake fragmentation, including ameliorated cognition. Results from this project may lead to an inexpensive or free scalable intervention with the potential to ameliorate cognitive decline and other concomitants of fragmented sleep, delay institutionalization, and improve the quality of life in older individuals.

PI_NAMEs: LOK, RENSKE  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Accelerometer;Address;Adverse effects;Age;Aging;Algorithms;Alzheimer's Disease;Anxiety;apolipoprotein E-4;Artificial Intelligence;Behavioral Sciences;Big Data;Big Data Methods;Blood;career;career development;Caring;Cause of Death;Chronobiology;circadian;circadian pacemaker;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive testing;Communities;Data;data modeling;Data Set;Decision Making;deep neural network;design;Deterioration;Development;Development Plans;Effectiveness;effectiveness evaluation;empowerment;Ensure;Environment;Etiology;expectation;Exposure to;flexibility;Genotype;Gerontology;Goals;Grant;Health;Hour;Human;Impaired cognition;improved;improvement on sleep;Individual;Institutionalization;Interdisciplinary Study;International;Interruption;Intervention;Intervention Studies;Knowledge;Lasso;Learning;Learning Skill;Light;Literature;Long-Term Effects;Machine Learning;machine learning algorithm;mathematical model;Measures;Medical;men;Mental Depression;Mental Health;Mentors;mild cognitive impairment;Modeling;Moods;neurocognitive test;Neuropsychology;novel;older adult;Older Population;Onset of illness;osteoporosis with pathological fracture;Outcome;Output;Participant;Patients;Pattern;Personal Satisfaction;Persons;Phase;Phototherapy;Physicians;Physiological;Population;precision medicine;prevent;prodromal Alzheimer's disease;Productivity;Psychiatry;Publishing;Quality of life;Questionnaires;random forest;Reporting;Research;research data dissemination;Research Personnel;Research Support;Research Training;Resources;Risk Factors;Secondary to;skill acquisition;skills;Sleep;Sleep Disorders;Sleep Fragmentations;Sleep Wake Cycle;social determinants;Solid;standard of care;Statistical Data Interpretation;Techniques;Testing;Therapeutic Intervention;therapy design;Time;tool;Training;United States;Universities;Woman;Writing

PROJECT_TITLE: Application of precision medicine to phototherapy: a stepped care approach to consolidate sleep and slow cognitive decline in older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CHAPEL HILL

ORG_DEPT: UROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE United States value-based reforms targeting surgical conditions have had a modest effect on perioperative costs and outcomes, which may be related to misguided policies that reward strategies seeking to minimize post-operative care variation rather than streamlining the sequence of episode-specific events preceding surgery. Reframing current value-based surgical reforms to capture both patient/provider perspectives and a broader set of episode-specific clinical and non-clinical events will have the dual effect of improving surgical value and better aligning policies with patient/provider needs. By employing a mixed methods approach to surgical episode modeling and evaluation, this proposal will lay the foundation for a future clinical decision aid that targets at-risk populations with structural interventions to improve surgical value by reducing variation in perioperative care intensity and duration.

PI_NAMEs: FRIEDLANDER, DAVID  (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Using mixed methods to reduce disparities in renal colic care: a model for surgical value transformation

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PI_NAMEs: AGARWAL, PUJA  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: African American;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Animals;Anti-Inflammatory Agents;Antioxidants;Astrocytes;Autopsy;Biological Markers;blood-based biomarker;Brain;brain health;Brain region;brain tissue;Cellular Stress;Clinical;clinical diagnosis;Cognition;Cognitive;cognitive function;cohort;Collection;Communities;Data;Dementia;design;Diet;dietary;dietary approach;Dietary Factors;Dietary Intervention;Disparity;Essential Fatty Acids;Evaluation;Flavonoids;follow-up;Glial Fibrillary Acidic Protein;Glutathione;Goals;good diet;Grant;Health Benefit;Hippocampus;Human;Immune;Impaired cognition;Inflammatory;innovation;insight;Intervention;Knowledge;Latino;Light;Link;Lipid Peroxidation;lipidomics;Lipids;Measures;Mediating;Memory;Microglia;Minority;Nerve Degeneration;neurofilament;neuroinflammation;neuropathology;novel;Nutrient;Outcome;Oxidative Stress;oxidized lipid;participant enrollment;Pathogenesis;Pathologic;Pathology;Pathway interactions;personalized nutrition;Persons;Phosphorylation;Plasma;Polyunsaturated Fatty Acids;Population;Population Heterogeneity;Prevention strategy;protective effect;Proteomics;Public Health;Race;racial difference;Reporting;Research;research clinical testing;research study;resilience;response;Risk;Risk Reduction;Sampling;sex;Sex Differences;Specimen;Structure;systemic inflammatory response;tau Proteins;tau-1;Techniques;Testing;Tissue Banks;trait;Underrepresented Populations

PROJECT_TITLE: Dietary factors, neuroinflammation, plasma neurodegenerative biomarkers and Alzheimer’s disease in diverse cohorts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-E (02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROLOGY

PHR: Project Narrative This study investigates how a fundamental cellular process called autophagy, which degrades damaged proteins, functions to maintain the health of human brain cells and how defects in this process place individuals at great risk for developing dementia and amyotrophic lateral sclerosis. The proposed research supports the identification of new therapeutic strategies for age-related neurodegenerative diseases that are steadily increasing in prevalence in our population.

PI_NAMEs: MORDES, DANIEL ADAM (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Affinity Chromatography;age related neurodegeneration;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Apoptosis;Autophagocytosis;Autophagosome;Behavior;Biochemical;Biological Assay;brain cell;Cell Line;Cell Physiology;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoplasm;Cytoplasmic Protein;Defect;Dementia;Development;Disease;Electron Microscopy;excitatory neuron;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Generations;Genetic;Goals;Golgi Apparatus;Health;Human;human stem cell-derived;human stem cells;improved;In Vitro;Individual;induced pluripotent stem cell;Language;Link;loss of function;Lysosomes;Maps;Mass Spectrum Analysis;Mediating;Mitochondria;motor deficit;mouse model;Mutation;Natural Immunity;Nerve Degeneration;Nerve Regeneration;neural;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;new therapeutic target;novel;novel therapeutic intervention;Organelles;Paralysed;Parkin;Parkinson Disease;Pathway interactions;Personality;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Population;Prevalence;prevent;Process;Protein Family;Protein Kinase;protein protein interaction;Proteins;Proteomics;proteostasis;Quality Control;receptor;Regulation;Research Support;Ribonucleoproteins;Risk;Role;stem cell model;stem cells;Structure;TBK1 gene;Testing;Therapeutic;Variant

PROJECT_TITLE: Defining TBK1-associated autophagy networks in neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Narrative This diversity supplement to R21AG083393 will provide funding for Mr. Michael Segovia, a rising scholar from an underrepresented group, to (1) conduct research related to the Parent Grant focusing on the interaction between rural/urban residential context and state-level policies for mid-age adults in line with NIA’s Strategic Goals B and F, (2) be exposed to theoretical frameworks that guide aging research, and (3) develop research skills. The candidate will also benefit from opportunities available through the numerous research centers and research activities occurring at the Pennsylvania State University. Mr. Segovia will be integrated into the Research Team and Penn State as a Postbaccalaureate Researcher.

PI_NAMEs: SANTOS-LOZADA, ALEXIS R (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Age;aged;Aging;aging population;Alcohol consumption;Area;Attention;Businesses;Cardiovascular system;Cessation of life;Child;Collaborations;Computer software;court;COVID-19 pandemic;COVID-19 pandemic effects;Data;Death Rate;deprivation;design;Doctor's Degree;Eligibility Determination;Environment;Ethnic Origin;Exhibits;experience;Exposure to;Funding;Goals;graduate school;Growth;Health;health care availability;Health Disparities Research;health disparity;Health Fairs;Health Insurance;Health Policy;Health Services Accessibility;Health Status;improved;Individual;Insurance;Insurance Coverage;Internships;Left;Literature;Logistic Regressions;Mathematics;Medicaid;member;Mental Health;Mentors;Metabolic;Methods;Modeling;mortality;National Institute on Aging;Nature;novel;parent grant;Pattern;Pennsylvania;Persons;Physicians;Policies;Population;population health;population survey;Postbaccalaureate;Poverty;Process;programs;Public Health;Race;Recording of previous events;Reporting;Reproducibility;Research;Research Activity;Research Assistant;Research Personnel;Role;Rural;rural area;Rural Population;sex;sex disparity;Shapes;skills;socioeconomics;Statistical Models;success;summer research;Testing;Texas;Training;Underrepresented Populations;United States;Universities;urban area;urban disparity;Urban Population;urban residence

PROJECT_TITLE: Supplement: The impact of Medicaid expansion on the rural mortality penalty in the United States (Postbac)


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Inflammatory Bowel Disease;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative The prevalence of inflammatory diseases, including inflammatory bowel diseases (IBD), continues to rise worldwide, debilitating the quality of life of millions of people. Given the linked association between extraintestinal inflammation, such as inflammatory skin diseases, and susceptibility to IBD, improving our understanding of modulatory factors in such inter-organ inflammatory circuits may allow for rational therapeutic strategies and preventative medicines for IBD and other inflammatory diseases. Based on my recent findings that neuromedin U (NMU)-producing cholinergic neurons and group 2 innate lymphoid cells (ILC2s) cooperatively orchestrate the tissue-protective pathway in IBD pathogenesis, the focus of this proposal is to dissect the potential role of this neuro-ILC2 axis in the regulation of the inter-organ skin-gut inflammatory circuits.

PI_NAMEs: YANO, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Academy;Address;Advisory Committees;Allergic inflammation;animal facility;AREG gene;Bone Marrow;career;career development;cell motility;Chimera organism;cholinergic;cholinergic neuron;Chronic;chronic inflammatory skin;Collaborations;Committee Members;Communication;Complex;Core Facility;Crohn's disease;cytokine;Data;Development;Development Plans;Disease;Distal;Economic Burden;Educational workshop;Ensure;Enteral;Environment;Equipment;Etiology;experimental study;Exposure to;Flow Cytometry;Future;gastrointestinal;Gastrointestinal tract structure;Genetic;genetic approach;Goals;gut inflammation;Heart;high dimensionality;Homeostasis;Image;Immune;Immunity;Immunologics;improved;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;insight;Institution;intestinal homeostasis;Intestines;Kinetics;Laboratories;Link;loss of function;Lymphoid Cell;Mediating;Medicine;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;microscopic imaging;migration;Mind;Modeling;Molecular;mouse model;Mus;Nervous System;Neuroimmune;Neuromedin U;Neurons;Neuropeptides;neutrophil;New York;novel strategies;novel therapeutic intervention;novel therapeutics;Optics;Organ;Pathogenesis;Pathway interactions;Patients;Pattern;Persons;pharmacologic;Phase;Play;Predisposition;Prevalence;Preventive Medicine;Production;programs;protective pathway;Psoriasis;Public Health;Pyoderma Gangrenosum;Quality of life;rational design;Regulation;Reporter;Reporting;Research;Research Personnel;Research Training;Resources;response;Risk;Role;Science;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Skin;skin disorder;Skin Manifestations;Stimulus;Surface;Techniques;Testing;Therapeutic;Tissues;Training;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Ulcerative Colitis;Universities;Viral;Work;Writing

PROJECT_TITLE: Neuro-immune regulation of inter-organ skin-gut inflammation

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome

ORG_CITY: AUGUSTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Occlusive vascular diseases are the leading cause of death in the United States and worldwide. The proposed study focuses on investigating the function and the underlying mechanisms of the uncharacterized nuclear protein HMGXB4 in vascular smooth muscle cells related to occlusive vascular diseases. Completion of the proposed studies will provide novel insights into the mechanisms regulating smooth muscle inflammation and phenotypic switching, and will determine if inhibiting HMGXB4 is an attractive novel therapeutic strategy for ameliorating occlusive vascular diseases.

PI_NAMEs: HE, XIANGQIN  (contact)

PROJECT_TERMS: Angioplasty;Aorta;Arterial Fatty Streak;Arterial Injury;Arteries;Atherosclerosis;Attenuated;Automobile Driving;Binding;Binding Sites;Biological Assay;Blood Vessels;Cardiovascular Diseases;career;Cause of Death;Cell Differentiation process;Cell Nucleus;Cells;ChIP-seq;chromatin immunoprecipitation;Chromosomes;clinically significant;cofactor;Complex;Coronary Arteriosclerosis;Coronary artery;cytokine;Data;Data Set;Development;Disease;Dose;Endotoxins;Enhancers;epigenome;Epitopes;Etiology;Feedback;femoral artery;Gene Expression;Gene Silencing;Genes;genetic approach;Genetic Transcription;genetic variant;genome wide association study;genomic locus;Goals;graft failure;Growth Factor;HMG-Box Domains;Human;human model;Hyperlipidemia;In Vitro;in vitro Assay;in vivo;Inflammation;Inflammatory;Injury;insight;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;Lesion;Ligation;Luciferases;Mediating;Messenger RNA;Modeling;mouse model;multiple omics;Mus;myocardin;neointima formation;NF-kappa B;NFKB Signaling Pathway;novel;novel therapeutic intervention;Nuclear;Nuclear Protein;overexpression;p65;Pathologic;Pathway interactions;pharmacologic;Phase;Phenotype;Phosphorylation;PIM1 gene;Proliferating;promoter;Proteins;Reporter;Research;restenosis;Risk;Role;Sampling;Saphenous Vein;Serum Response Factor;single nucleus RNA-sequencing;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;Stimulus;systemic inflammatory response;Testing;Time;Training;transcriptome;United States;vascular contributions;Vascular Diseases;vascular inflammation;Vascular remodeling;Vascular Smooth Muscle;Vein graft

PROJECT_TITLE: The uncharacterized nuclear protein HMGXB4 in occlusive vascular diseases


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Cancer;Emerging Infectious Diseases;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD);Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The computational methodologies we develop will be applicable to a broad range of conformational changes of RNA polymerases with biomedical relevance. In particular, oxidative DNA lesions cause transcriptional mutagenesis of RNA Polymerase II that contributes to tumor growth in skin cancer, and mechanistic insights from this work will help uncover a route to address the adverse effects of these DNA lesions. In addition, antibiotics against Mycobacterium tuberculosis (Mtb) often target the dynamic motion of its RNA polymerase, and this work will provide mechanistic insights to facilitate the rational design of new antibiotics fighting drug resistance of Mtb.

PI_NAMEs: HUANG, XUHUI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Adverse effects;Antibiotics;base;Biochemical;Biological;Biophysics;Cessation of life;code development;Communities;Complex;computer framework;Computer software;Computing Methodologies;Coupling;Cryoelectron Microscopy;Development;DNA;DNA Damage;DNA lesion;DNA-Directed RNA Polymerase;Drug resistant Mycobacteria Tuberculosis;Electronics;Equation;Event;experimental study;fighting;Genetic Transcription;guanidinohydantoin;inhibitor;innovation;insight;Lesion;Memory;Methodology;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;Motion;Mutagenesis;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;novel;operation;Polymerase;Protocols documentation;rational design;Request for Proposals;Research;RNA Polymerase II;Roentgen Rays;Rotation;Route;Skin Cancer;System;Testing;theories;Time;Transcription Initiation;Tuberculosis;tumor growth;Work

PROJECT_TITLE: Theory and Modeling of Functional Conformational Changes of RNA Polymerases_Diversity Supplement

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Inequities in substance use disorder pose significant risk to Indigenous communities in the United States (here, American Indians, Alaska Natives, and Native Hawaiians). Many Tribes and organizations serving Indigenous populations have been deeply committed to addressing substance use disorder, but since the preponderance of research has been designed and led from outside these communities, progress has been limited. Indigenous scientists have the potential to apply critical expertise from both scientific and community/cultural perspectives, but they remain significantly underrepresented among Principal Investigators funded by NIH. The NCRE Scholars Program invests in the career development of early stage Indigenous investigators to help prepare them to lead this research and close the equity gap.

PI_NAMEs: IVANICH, JERREED DEAN (contact);SARCHE, MICHELLE C

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: Address;Adolescence;Alaska Native;American Indians;Area;career;career development;Child;Child Development;Childhood;cohort;Collaborations;Communities;community engaged research;community partners;design;Development;Developmental Course;Discipline;Disparity;disparity gap;early childhood;early-career faculty;emerging adult;Face;Faculty;Family;Fostering;Foundations;Funding;graduate student;Grant;Health;improved;Indigenous;indigenous community;Inequity;innovation;Intervention;Intervention Studies;Investments;Knowledge;Lead;Leadership;Learning;Lived experience;Measurement;member;Mentors;Mentorship;Methodology;National Institute of Drug Abuse;Native Americans;Native Hawaiian;Native-Born;next generation;opioid epidemic;peer;Phase;Play;Population;Positioning Attribute;Postdoctoral Fellow;prenatal;prevent;Prevention;Principal Investigator;programs;Qualitative Methods;recruit;Research;Research Design;Research Personnel;Rest;Risk;Role;Scholars Program;Science;Scientist;Seasons;skills;Societies;substance use;Substance Use Disorder;success;symposium;Technical Expertise;Training;training opportunity;tribal health;Tribes;United States;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Preparing Indigenous Scientists to Lead Innovative Substance Use Research: The Native Children's Research Exchange Scholars Program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Breastfeeding, Lactation and Breast Milk;Clinical Research;Diabetes;Menopause;Neurosciences;Nutrition;Osteoporosis;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PHR: PROJECT NARRATIVE Bone quality deteriorates with obesity, diabetes, and aging and increases bone fragility and fractures. There is a need to identify new therapeutic targets for improving skeletal health, especially during the perimenopause transition and in later life stages when many more women suffer from age-related diseases, obesity, and type 2 diabetes mellitus (T2D). The studies outlined in this proposal aim to determine the role of brain-derived cellular communication network factor 3 (CCN3), a new therapeutic target, in bone and marrow fat metabolism.

PI_NAMEs: BABEY, MURIEL  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Adipose tissue;Affect;age-related disease;aged;Aging;aging population;Appearance;Biological Assay;bone;Bone Density;bone fragility;Bone Injury;bone loss;Bone Marrow;bone mass;bone quality;Brain;California;career;career development;Clinical;Clinical Trials;Communication;Coupled;Deterioration;Development;Development Plans;Diabetes Mellitus;dietary;disease model;Dose;Endocrinology;Estrogen Receptors;Etiology;Exposure to;Fatty acid glycerol esters;Fellowship;Female;Femur;Financial Hardship;Fracture;fracture risk;Future;Genetic;Goals;Grant;Health;High Fat Diet;Holly;Hormones;Human;Hypothalamic structure;improved;In Vitro;in vivo;in vivo Model;KISS1 gene;knock-down;Lactation;late life;Learning;Link;lipid metabolism;Longevity;male;Marrow;Measures;Medial;Mediating;Medicine;Menopause;Mentors;Mentorship;Metabolic;Metabolism;Modeling;Mothers;Mus;mutant;nanomolar;National Institute of Diabetes and Digestive and Kidney Diseases;Nerve;Neurons;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;offspring;Operative Surgical Procedures;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;Outcome;Ovariectomy;overexpression;Patients;Perimenopause;Phenotype;Physicians;Physiological;Physiology;Play;Postmenopause;professor;programs;Regulation;Research;response;Role;San Francisco;Scientist;skeletal;Skeletal bone;skeletal disorder;skeletal stem cell;Skeleton;skills;small hairpin RNA;stem cell biology;stem cell niche;Structure of nucleus infundibularis hypothalami;Switzerland;Testing;therapeutic target;Training;Transcript;Universities;Woman;Work;Writing

PROJECT_TITLE: Determining the Role of Brain-Derived CCN3 in Bone and Marrow Fat Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


PHR: PROJECT NARRATIVE Mounting evidence support the idea that aging is rooted in metabolic dysfunction, which occurs when chemical reactions become dysregulated during aging and negatively alters the body's processing and distribution of nutrients, inducing the aberrant accumulation of certain metabolites. Identifying metabolic pathways and metabolites that drive cell senescence and metabolic dysfunction is critical to understanding and treating age- related diseases. This project aims to unravel the association between propionate metabolism and aging, providing insights into potential diagnostic biomarkers and therapeutic targets for mitigating aging and age- related diseases.

PI_NAMEs: LI, ZHONGCHI  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acceleration;Acetylation;Acylation;Address;Affect;Age;age-related disease;Aging;aging process;aging related;aging related disease;Amino Acids;Award;Biology;Biology of Aging;Catalogs;Cell Aging;Cell Physiology;Cellular biology;Central obesity;chemical reaction;Cholesterol;Chromatin;Chronic;Critical Pathways;Data;Deposition;Diabetes Mellitus;diagnostic biomarker;Ensure;Epigenetic Process;Exhibits;Fatty acid glycerol esters;Fatty Acids;Fibroblasts;Fibrosis;Foundations;Funding Opportunities;Gene Expression;General Population;Genes;Grant;hallmarks of aging;Health;Histone H3;Histones;in vivo;Individual;Inflammation;insight;Insulin Resistance;insulin sensitivity;Investigation;Kidney;life span;Link;lipid metabolism;Lipids;Liver;Lysine;Malignant Neoplasms;Manuscripts;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Metabolic Pathway;metabolic profile;Metabolism;Methylmalonic Acid;mitochondrial dysfunction;Modification;mortality;Mus;non-histone protein;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obesity;Organ;Organism;Paper;Pathway interactions;Peripheral;Phase;Phenotype;Physiological;Physiology;Play;Post-Translational Protein Processing;Predisposition;Preparation;Process;Propionates;propionyl-coenzyme A;protein function;Proteins;Pulmonary Fibrosis;Reactive Oxygen Species;Regulation;Research Personnel;Research Project Grants;Role;senescence;senescent cell;Serum;Signal Transduction;Systemic disease;therapeutic target;Tissues;TP53 gene;Training;Translating;tumor progression;Visceral;Visceral fat;Work

PROJECT_TITLE: Investigating the link between propionate metabolism and aging


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Social Determinants of Health;Telehealth;Transplantation

PHR: PROJECT NARRATIVE Despite ample evidence of the benefits of cardiac rehabilitation, only a small fraction of transcatheter aortic valve replacement patients participate. This proposed research tests the use of clinically controlled, commercially available fitness programming (Rehabbing with Peloton) that targets physical activity and cardiovascular health outcomes. Commercially available mobile health provides an opportunity to deliver cardiac rehabilitation content to a vulnerable population who are disproportionately excluded from CR services.

PI_NAMEs: KNOEPKE, CHRISTOPHER ;PORTZ, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Activities of Daily Living;aortic valve replacement;Area;attentional control;Blood Vessels;Cardiac rehabilitation;Cardiomyopathies;cardiovascular health;Cardiovascular system;Cities;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;Colorado;comorbidity;Coupled;Dedications;design;digital health;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;efficacy testing;Eligibility Determination;Ensure;ethnic minority;Evaluation;Exclusion;Exercise;exercise capacity;exercise training;experience;fitness;follow-up;functional status;Future;General Population;Goals;Health;Health Status;Heart;Home;Hospitals;implementation evaluation;implementation intervention;implementation strategy;improved;indexing;Individual;Inequity;innovation;insight;Institutional Review Boards;Interdisciplinary Study;interest;Intervention;Kansas;Knowledge;Life;low socioeconomic status;Macrophage-1 Antigen;Manuals;Measures;Methodology;Methods;mHealth;mobile application;mobile computing;Morbidity - disease rate;mortality;Motivation;Outcome;Participant;patient engagement;Patient Participation;Patients;Personal Satisfaction;Phase;Physical activity;Physiologic Monitoring;Population;Positioning Attribute;post intervention;Principal Investigator;Procedures;Quality of life;Questionnaires;racial minority;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;recruit;rehabilitation service;Rehabilitation therapy;remote monitoring;Reporting;Research;Research Personnel;rural area;Safety;Schedule;Scientist;secondary outcome;smart watch;social;social engagement;Stretching;Technology;Testing;Time;Transportation;Universities;uptake;VO2max;Vulnerable Populations;Waiting Lists;Walking;Woman;Work;Yoga

PROJECT_TITLE: Rehabbing with Peloton: Commercially Available Fitness mHealth for Cardiac Rehabilitation among Individuals Recovering from Transcatheter Aortic Valve Replacement

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (MA)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_DEPT: PHYSIOLOGY

PHR: PROJECT NARRATIVE Acinar-to-ductal metaplasia and pancreatic intraepithelial neoplasia are precancerous lesions and risk factors for the development of pancreatic ductal adenocarcinoma. This proposal addresses: 1. how metabolic changes in cellular redox pathways drive precancer and 2. how the metabolic microenvironment regulates aspects of cell competition during metaplastic transformation. Insights from the proposed experiments will connect major metabolic pathways with precancerous states and inform new insights into pancreatic disease.

PI_NAMEs: RADYK, MEGAN DEANNA (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Acceleration;Acinar Cell;Address;Anabolism;Antioxidants;antiporter;biobank;Biomass;Buffers;Cancer Etiology;cancer initiation;Cell Culture Techniques;Cell secretion;cell type;Cells;Cellular Metabolic Process;Cessation of life;Coculture Techniques;cofactor;Communication;Complex;Critical Pathways;Cystine;Data;Detection;Development;driver mutation;Duct (organ) structure;Early Diagnosis;effective therapy;Environment;Enzymes;experimental study;G6PD gene;Galactose Binding Lectin;Genes;Genetic;Genetically Engineered Mouse;Glucosephosphate Dehydrogenase;Glucosephosphate Dehydrogenase Deficiency;Glutamine;Glutathione;Glutathione Disulfide;Grant;Growth;Homeostasis;Human;in vivo;injured;Injury;innovation;insight;Isotopes;K-ras mouse model;KRAS oncogenesis;KRAS2 gene;KRASG12D;Lead;Lesion;LoxP-flanked allele;Malates;malic enzyme;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Metaplasia;Modeling;mouse model;Mouse Strains;Mus;Mutation;NADP;novel;Oncogenes;Oncogenic;Organ;Oxidation-Reduction;Pancreas;pancreas development;pancreatic cancer model;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;pancreatic metaplasia;pancreatic neoplasm;pancreatic tumorigenesis;Pathway interactions;pharmacologic;Precancerous Conditions;premalignant;Process;Production;Proliferating;Pyruvate;Reactive Oxygen Species;Recycling;Reduced Glutathione;regenerative;Regulation;repaired;Repression;Risk Factors;Role;Supporting Cell;Survival Rate;System;Testing;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;transdifferentiation;tumor;tumor progression;tumorigenesis;Work

PROJECT_TITLE: Metabolic regulation of pancreatic metaplasia and neoplasia

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Nutrition;Pediatric;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE The carbon stable isotope ratio (CIR), which can be sampled from breath, blood, and hair, is an objective, low- burden, and valid method for capturing added sugar (AS) intake but remains understudied in real-world behavioral interventions with youth. This study will examine CIR from breath as a novel measure of intervention adherence (i.e., short-term AS intake) and intervention effectives (i.e., change in AS intake) among adolescents (n=70) 12-16 years participating in a 12-week behavioral randomized controlled trial to reduce AS intake. Findings will provide evidence on the comparative feasibility, acceptability, and sensitivity to change of different CIR sample types (e.g., breath, blood, hair) to inform a fully powered R01 trial and yield important insights to address limitations associated with adherence and self-report in dietary intervention trials.

PI_NAMEs: TRIPICCHIO, GINA L. (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;age group;Behavior Therapy;Behavioral;Behavioral trial;Belief;Biological Markers;Blood;Calories;Canes;Carbon;Carbon Isotopes;Chronic Disease;Collection;comparative;Consumption;Data;design;Development;Diet;Diet Habits;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;disorder risk;Ecological momentary assessment;Education;effective intervention;Effectiveness;Effectiveness of Interventions;Enhancement Technology;ethnic diversity;Fasting;feeding;Fructose;Future;Goals;Hair;Health;health disparity;Hour;improved;innovation;insight;Intake;Intervention;intervention participants;Intervention Trial;Investigation;Length;Life Cycle Stages;Maps;Measures;Methodology;Methods;novel;Nutrient;nutrition;nutrition education;Nutritional;Outcome Assessment;Participant;Patient Self-Report;Phase;Philadelphia;Population;Predisposition;Preparation;racial diversity;Randomized;Randomized, Controlled Trials;Religion;Reporting;Research;response;Risk;Sample Size;Sampling;Science;Social Desirability;Source;stable isotope;sugar;Surveys;sweetened beverage;Testing;Text Messaging;Time;tool;Unhealthy Diet;Variant;Weight;Work;Youth

PROJECT_TITLE: Biomarker Assessment of Adherence and Effectiveness in a Randomized Controlled Trial to Reduce Added Sugar Intake in Adolescents


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: The formation of long term memories requires correct functioning of the entorhinal cortex and hippocampus. In Alzheimers disease, function of the entorhinal cortex and hippocampus are affected by pathological forms of the protein tau, which is thought to contribute to cognitive and memory impairments associated with the disease. This proposal will investigate how pathological tau potentially impairs the function of select vulnerable neurons in the hippocampus.

PI_NAMEs: MCQUISTON, ADAM RORY (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: adeno-associated viral vector;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Antibodies;biocytin;Brain;brain cell;Brain Diseases;Brain region;calbindin;Calcium-Binding Proteins;cell type;Cells;Complex;Country;Dementia;dentate gyrus;design;Disease;Disease Progression;economic cost;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;entorhinal cortex;Experimental Designs;Frontotemporal Lobar Degenerations;Functional disorder;Future;Genetic Vectors;Health;hippocampal pyramidal neuron;Hippocampus;Human;Hybrids;hyperphosphorylated tau;Immunofluorescence Immunologic;Impaired cognition;Impairment;in vivo calcium imaging;Interneuron function;Interneurons;long term memory;Medial;Memory impairment;Memory Loss;Methods;Microtubule Stabilization;Monitor;mouse genetics;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuronal excitability;Neurons;Outcome;Output;patch clamp;Pathogenicity;Pathologic;Pathology;Persons;Physiological;postsynaptic;Preventive treatment;Process;programs;Property;protein expression;Proteins;Pyramidal Cells;reconstruction;Role;Senile Plaques;Severities;Slice;Symptoms;Synapses;synaptic function;tau aggregation;tau conformation;tau mutation;tau Proteins;tau-1;Therapeutic;therapy development;Transgenic Mice;transmission process;Viral Vector

PROJECT_TITLE: Cell type vulnerability to pathogenic tau accumulation in hippocampal CA1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Substance Misuse;Substance Misuse Prevention

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  This study will develop and test a novel culturally tailored family-based videogame, FamilyBond, to prevent worsening substance misuse among urban Black adolescents in community-based primary care settings by addressing both universal and unique risk and protective factors for this population. Findings from the study will provide the first effective family-based digital intervention to lower intentions to misuse substances among urban Black adolescents. The intervention will reduce barriers to accessing care among Black adolescents and their parents by delivering a mobile videogame intervention in primary care settings.

PI_NAMEs: ANENI, KAMMARAUCHE  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: 17 year old;Address;Adolescent;Age;aged;Alcohols;Area;arm;barrier to care;Black race;care providers;career;Caregivers;Childhood;clinical training;Communication;Communities;community engaged research;community violence;design;Development;digital;digital intervention;Drug Prevention Program;effective intervention;Ethnic Origin;evidence base;experience;Exposure to;Face;Family;Focus Groups;Goals;Grant;handheld mobile device;Health Services Accessibility;Illicit Drugs;implementation science;improved;Individual;innovation;Intention;Intervention;Justice;Knowledge;Life;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modification;National Institute of Drug Abuse;Needs Assessment;novel;novel strategies;Overdose;parent-adolescent communication;parent-child communication;Parents;Perception;Personal Satisfaction;Pharmaceutical Preparations;Play;Population;Positioning Attribute;prevent;preventive intervention;primary care setting;primary outcome;programs;protective factors;prototype;Public Health;Race;racism;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Personnel;Research Training;responsible research conduct;retention rate;Risk;Risk Factors;Rural;rural setting;Schools;Scientist;Self Administration;Self Efficacy;skills;Socialization;Strategic Planning;substance misuse;substance misuse prevention;substance use;substance use prevention;System;Testing;Time;Tobacco;Training;uptake;usability;Video Games;videogame intervention;Writing

PROJECT_TITLE: A Family-Based Digital Intervention to Address Early Substance Misuse among Black Adolescents

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The overall prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease and related dementias (ADRD) is increasing worldwide. Our proposed project aims to examine the impact that early diagnosis of MCI and ADRD has on employment, care trajectories, and quality of life. This research will identify health policies that can best protect the most vulnerable from the negative consequences of ill-health.

PI_NAMEs: PAPANICOLAS, IRENE N (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Accounting;Adherence;Age;Aging;Alzheimer's disease related dementia;Awareness;Behavior;care delivery;care systems;Caring;Characteristics;Cognitive;cognitive testing;Communication;comparative;Country;Data;Data Collection;data harmonization;Data Linkages;Data Protection;Dementia;dementia care;Denmark;Detection;Diagnosis;Disease;Early Diagnosis;early experience;Educational Status;Employment;England;Ensure;Environment;ethnic minority;Europe;European;experience;Family;federated learning;financial incentive;Finland;France;Future;Goals;Health;health care delivery;health data;health determinants;health difference;health economics;Health Policy;Health Services Accessibility;Health Surveys;Health system;Healthcare;Healthcare Systems;Heterogeneity;Impaired cognition;improved;Income;Individual;innovation;Institutionalization;International;Intervention;Korea;Koreans;Labor Forces;Learning;learning algorithm;Life;Link;Longitudinal Surveys;Measures;meeting reports;Methods;mild cognitive impairment;Modification;multidisciplinary;National Health Services;Netherlands;Neurobehavioral Manifestations;older adult;optimal treatments;Outcome;Patient Care;Patients;Pattern;peer;Persons;Policies;Population;Prevalence;prevent;Primary Care;Process;programs;Quality of life;racial minority;Recording of previous events;Research;Resources;Retirement;Risk Factors;Sampling;screening;Societies;socioeconomic disparity;socioeconomics;Surveys;symptom management;System;Time;trend;United States;Variant;Work;Workplace

PROJECT_TITLE: PrEDICT ADRD: Predicting the Effects of Diagnosis in Individuals across Countries and Time in ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Compulsively persisting with fixed ways of behaving even when negative consequences mount is a central component of many psychiatric disorders. For the first time in psychiatry, is it now possible to longitudinally record from neural circuits during a patient’s treatment course, and to do so while administering sophisticated tests of cognition. Directly studying the neural circuits of individuals undergoing treatment for compulsivity may reveal the biological basis for the kind of rigid thinking and behavior present in a wide range of devastating mental disorders.

PI_NAMEs: SMITH, ANDREW HOWARD (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Acting Out;Anterior;Basal Ganglia;Behavior;Behavioral;Biological;Biological Assay;Body Dysmorphic Disorder;Brain;Chronic;Clinical;clinically relevant;Cognition;Cognitive;cognitive change;cognitive process;cognitive task;Compulsive Behavior;Compulsive Hoarding;Computer Models;Country;Data;Decision Making;Deep Brain Stimulation;Devices;Diagnostic;Disease;efficacious treatment;Electrodes;Electrophysiology (science);Ensure;Environment;Evolution;experience;Experimental Designs;Family member;flexibility;Frequencies;Funding;Ganglia;Generations;Gilles de la Tourette syndrome;Globus Pallidus;Goals;Human;human subject;Implant;implantation;improved;Individual;Internal Capsule;Lead;Limb structure;Measures;Mental disorders;Mentors;Mentorship;millisecond;Modeling;Motor;Names;neural;neural circuit;Neurosciences;new technology;Obsessive-Compulsive Disorder;Operative Surgical Procedures;Participant;Pathway interactions;Patients;Pattern;Procedures;Process;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;Qualifying;Refractory;Research;Resistance;restraint;Reversal Learning;Signal Transduction;stem;Structure of subthalamic nucleus;Substance Use Disorder;Techniques;Testing;Therapeutic;Thinking;Time;Training;United States Food and Drug Administration;United States National Institutes of Health;white matter

PROJECT_TITLE: Direct characterization and correction of circuit level computational deficits underlying compulsivity in humans

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Immunotherapy;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative α-Synucleinopathies, which exhibit strong associations with Alzheimer's Disease and Related Dementia (ADRD), have raised the possibility of T-cell immunity involvement in α-synuclein propagation. An interdisciplinary research team will systematically investigate T-cell responses to pathogenic α- synuclein, their influence on α-synuclein propagation, and the potential therapeutic applications of immunotherapy. These investigations aim to elucidate the intricate disease mechanisms, identify T-cell related molecular determinants in α-synucleinopathy-related ADRD, and provide novel insights into therapeutic strategies.

PI_NAMEs: MAO, XIAOBO  (contact);PENG, WEIYI

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immunity;Address;Adoptive Transfer;Affect;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Antibodies;Antigens;Area;Bioinformatics;Biological Assay;Blood;Brain;brain tissue;CD8-Positive T-Lymphocytes;cell mediated immune response;Cell Physiology;Cell Separation;Cellular biology;Cellular Immunity;Cellular immunotherapy;Complex;cytotoxicity;Data;Dementia with Lewy Bodies;Development;Disease;effector T cell;Exhibits;Flow Cytometry;Future;Gastrointestinal tract structure;Gene Modified;Genetic;Goals;gut-brain axis;Immune;Immune response;Immunity;Immunologic Factors;Immunologics;Immunology procedure;immunoregulation;Immunotherapy;Impaired cognition;In Vitro;in vivo;Individual;Infiltration;innovation;insight;Interdisciplinary Study;Interferon Type II;Investigation;Knock-out;Knowledge;Lewy Body Dementia;Mediating;MHC Class I Genes;Modeling;Molecular;monocyte;mouse model;multiple omics;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurologic;neuron loss;Neurons;neuropathology;neutralizing antibody;novel;Parkinson Disease;Parkinson's Dementia;Pathogenesis;Pathogenicity;Pathology;Play;pre-formed fibril;prion-like;Process;Production;Proteomics;Protocols documentation;receptor;Recombinants;Regulation;Regulatory T-Lymphocyte;Research;response;Role;single cell technology;Site;Specificity;Spleen;synucleinopathy;T cell clonality;T cell response;T-Cell Activation;T-Lymphocyte;TCR Activation;theories;Therapeutic;Tissues;transcriptomics;transmission process;Wild Type Mouse

PROJECT_TITLE: The cross-talk between a-Synucleinopathies and T cell immunity in ADRD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Emergency Care;Neurodegenerative;Palliative Care

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative The proposed research will develop and test an online Emergency Preparedness Toolkit to help caregivers prepare for their own unexpected health events. Caregivers of persons with dementia often ignore their own health needs as their primary focus is the care of the person with dementia. This can lead to a caregiver delaying their own care and subsequently emergent health events. The Emergency Preparedness Toolkit provides guidance to the caregiver as to how to identify and transfer care to a standby caregiver. The goal is to provide a caregiver with the security and comfort that the person with dementia will be well cared for while they care for their own health needs.

PI_NAMEs: BOXER, REBECCA SUE (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;adverse outcome;Caregiver Burden;Caregivers;caregiving;Caring;Chronic;comparative efficacy;Day Care;Dementia;dementia care;Dementia caregivers;design;Development;Distress;Eating;Emergency Care;emergency preparedness;Emergency Situation;Event;Exercise;falls;Family;Friends;Glean;Goals;Habits;Health;Health care facility;high risk;Hospitalization;Household;improved;Individual;Instruction;Intervention;Interview;Methods;Modeling;online version;Outcome;Paper;Persons;Quality of life;Randomized;randomized, clinical trials;Readiness;recruit;Research;Rewards;Risk;Role;Security;Self Efficacy;Sleep Deprivation;Spouse Caregiver;Spouses;Structure;success;Surveys;Target Populations;Testing;tool;United States National Institutes of Health;Work

PROJECT_TITLE: Caregivers Preparing for Their Own Health Care Emergency

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Contraception/Reproduction;Palliative Care;Patient Safety;Pediatric

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Adolescents and young adults with differences of sex development make critical and potentially irreversible, life-altering surgical decisions about their bodies without standardized resources to support their engagement in shared decision making. To fill this gap, the proposed research will examine the decisional needs of adolescents and young adults with differences of sex development, as well as develop and pilot a set of surgical decision aids addressing identified needs. Standardized decision aid use will promote adolescent and young adult engagement in shared decision making, leading to improved care, patient health, and psychosocial outcomes.

PI_NAMEs: SUORSA-JOHNSON, KRISTINA IRENE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Anatomy;Award;career;career development;Caregivers;Caring;Child;Childhood;Clinic;Clinic Visits;Clinical;Clinical Management;Clinical Trials;Code;Collaborations;community advisory board;Conflict (Psychology);Data;Decision Aid;Decision Making;Dedications;design;Development;dissemination science;Doctor of Philosophy;Education;Educational Materials;Elements;Ensure;evidence base;Exercise;Feedback;Funding;Future;Genitalia;Genitourinary system;Goals;Health;Health education;Health Personnel;implementation science;improved;Infant;innovation;International;Intervention;Interview;Jordan;Knowledge;Leadership;Licensing;Life;Lived experience;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;multi-site trial;National Institute of Child Health and Human Development;Nature;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;patient engagement;Patients;pediatric health outcomes;pediatric patients;Perception;Persons;physical conditioning;pilot test;pilot trial;Population;preference;Process;Provider;Psychologist;psychosocial;psychosocial outcome;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Registries;reproductive;Research;Research Personnel;Research Training;Resources;Risk;sex development disorder;Sexual and Gender Minorities;Sexual Development;Sexual Health;shared decision making;Site;skills;Standardization;standardized care;success;support tools;Surveys;Techniques;Testing;tool;Training and Education;Training Programs;Translational Research;treatment as usual;trial design;United States National Institutes of Health;Urogenital Surgical Procedures;user centered design;Work

PROJECT_TITLE: Adolescents and Young Adults: Dilemmas, Education, and Choices Impacting Decisions (AYAs DECIDe) Study

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Social Determinants of Health;Vaccine Related

PHR: Project Narrative Seasonal influenza causes 290,000-645,000 deaths annually and many of these deaths are in low-middle income countries especially in particularly vulnerable groups such as infants, pregnant women, and the elderly. However, how influenza transmits between members of a household is not well understood in low-middle income countries. This project hopes to fill the gap in knowledge of how influenza spreads within-households in low-middle income countries and has the potential to influence vaccination and mitigation measures recommended in these countries.

PI_NAMEs: PISCHEL, LAUREN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 14 year old;age group;age related;aged;Award;Binomial Model;Biological Assay;burden of illness;career;Caregivers;Cessation of life;Child;Clinical;cohort;Communicable Diseases;Communities;Country;COVID-19;Data;demographics;design;Disease;Disease Outbreaks;Disease Surveillance;disease transmission;Elderly;Emerging Communicable Diseases;emerging infectious disease model;Ensure;epidemiological model;Epidemiology;experience;face mask;Federal Government;flu transmission;Foundations;Funding;Goals;Grant;Guatemala;Guidelines;Hemagglutination;Heterogeneity;Household;Income;indexing;India;Individual;Infant;Infection;infection risk;Infectious Disease Epidemiology;infectious disease model;Influenza;Influenza A virus;Influenza B Virus;Influenza vaccination;influenza virus vaccine;International;Intervention;Investigation;Knowledge;Link;Literature;low and middle-income countries;Markov Chains;Measures;member;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Mothers;Mozambique;Nasal turbinate bone structure;Nose;Patient Self-Report;Pattern;Physicians;Policies;Population;Populations at Risk;Positioning Attribute;Pregnant Women;Preparation;Probability;prospective;Prospective cohort;Public Health;Public Sector;Recommendation;Research;Resolution;Resource-limited setting;Resources;respiratory;Respiratory Disease;Respiratory Tract Infections;Reverse Transcriptase Polymerase Chain Reaction;Risk;Risk Estimate;Saliva;Sampling;Schools;seasonal influenza;sensor;Serology;Serology test;Seroprevalences;Site;skills;social;social contact;Structure;success;Techniques;Training;transmission process;United States National Institutes of Health;Vaccination;vaccine access;Virus;Vulnerable Populations;Work

PROJECT_TITLE: Investigation of within Household Transmission of Influenza in Low-Resource Settings

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Aging;Estrogen;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Loss of muscle strength occurs with age and in females estradiol deficiency contributes to strength loss. Through the uses of genetic, surgical, and pharmacological interventions to alter both estradiol levels and estrogen receptors, our project aims to not only expand our understanding of estrogenic mechanisms affecting skeletal muscle function in females but also determine if there is a role in preservation of muscle strength in males. Such understanding paves the way for estrogenic treatments that will impact the field of aging in both women’s and men’s health from multiple perspectives, beyond reproductive considerations

PI_NAMEs: LOWE, DAWN A (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Address;Adult;Affect;Age;age related;age-related muscle weakness;aged;Aging;Area;arm;Biochemical;Biological Assay;Calcium Signaling;Characteristics;combinatorial;Computer Models;Contractile Proteins;Coupled;Custom;Data;design;Development;differential expression;disability;Elderly;empowerment;ESR1 gene;Estradiol;Estradiol Receptors;Estrogen Receptors;estrogenic;Estrogens;extend lifespan;Female;frailty;Funding;Generations;Genetic;geroprotector;gerotherapeutic;Goals;Gonadal Steroid Hormones;GPER gene;GTP-Binding Proteins;healthspan;high throughput screening;Hormonal;human old age (65+);Impairment;improved;In Vitro;in vivo;Individual;innovation;insight;Interruption;Intervention;Knowledge;Ligands;male;male health;Measures;Mediating;Minor;Molecular;Monitor;Movement;Mus;Muscle;Muscle function;Muscle Proteins;muscle strength;Muscle Weakness;Muscular Atrophy;Musculoskeletal;novel;Operative Surgical Procedures;Outcome;Ovary;pharmacologic;Phosphopeptides;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphotransferases;Physical activity;Physiological;Physiology;preservation;Production;programs;Protein Kinase Protein Phosphorylation;protein structure function;Proteins;Quality of life;Reaction;receptor;Receptor Signaling;reproductive;Research;Research Personnel;Role;sex;Side;Signal Pathway;Signal Transduction;Signaling Protein;Skeletal Muscle;Techniques;Testing;Tissues;Woman;Work

PROJECT_TITLE: Interaction of estrogen, age, and activity on musculoskeletal strength in females

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Microbiome;Patient Safety;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Auto-brewery syndrome is a rare, but likely underdiagnosed condition in which intestinal microbes produce alcohol, which is absorbed into the bloodstream and results in intoxication. There is no accepted therapy for patients with auto-brewery syndrome. The primary goal of this clinical trial is to test safety and tolerability in eight patients with auto-brewery syndrome using fecal microbiota transplantation.

PI_NAMEs: HOHMANN, ELIZABETH L.;SCHNABL, BERND G. (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: absorption;Adult;Adverse event;Alcohol dehydrogenase;alcohol use disorder;Alcoholism;Alcohols;anti-fungal agents;Antibiotic Therapy;Antibiotics;Antifungal Therapy;Bacteria;Behavioral;Bioreactors;Blood;Blood Circulation;California;capsule;Carbohydrates;Case Study;Childhood;Clinical;clinical remission;Clinical Trials;cohort;Communicable Diseases;Data;Data Collection;Diagnosis;Dietary intake;Disease;Disease remission;Engraftment;Escherichia coli;Ethanol;experience;Exposure to;Family;Feasibility Studies;fecal microbiota;fecal transplantation;Feces;Fermentation;Flare;Gastrointestinal tract structure;General Hospitals;Genomic DNA;Goals;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Household;improved;Ingestion;Institutional Review Boards;Intestines;Intoxication;Klebsiella;laxative;Left;Legal;Liver diseases;Massachusetts;Measures;Medical;medical schools;Metabolic Diseases;metagenomic sequencing;Metagenomics;Microbe;microbial;microbiome;microbiome research;microbiota;Mission;Monitor;multidisciplinary;open label;Operative Surgical Procedures;Organism;Outcome;Pathologic;Patient-Focused Outcomes;Patients;Phase;Population;primary endpoint;Procedures;Production;Randomized Controlled Clinical Trials;rare condition;recruit;Registries;restoration;Saccharomyces cerevisiae;Safety;safety and feasibility;safety outcomes;safety testing;Short Bowel Syndrome;social;stool sample;Supervision;Syndrome;Techniques;Therapeutic;Universities;Visit;Writing;Yeasts

PROJECT_TITLE: Fecal microbiota transplantation for auto-brewery syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (01)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Sleep Research

ORG_CITY: CORAL GABLES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative This project will test the preliminary efficacy of a newly developed dyadic sleep intervention, My Sleep Our Sleep (MSOS), in a 2-arm randomized controlled, noninferiority trial design (MSOS vs Brief Behavioral Treatment for Insomnia, BBTI) on reducing sleep disturbance and improving health-related quality of life in both adult patients with cancer and their sleep-partner caregivers, and explore the roles of close relationship characteristics in the dyadic intervention. New knowledge from this project will guide comprehensive investigations on the psychosocial and biobehavioral factors of the dyadic sleep intervention for adult patients/survivors with cancer and their sleep-partner family caregivers. The knowledge from this project may also have substantial implications for traditional sleep research and telehealth practice with medical populations, shifting the emphasis from individual- to dyad/family-based approaches.

PI_NAMEs: KIM, YOUNGMEE  (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: 2 arm randomized control trial;acceptability and feasibility;actigraphy;Address;Adult;Agreement;arm;Beds;Behavior Therapy;Behavioral;biobehavior;biological adaptation to stress;Cancer Patient;cancer site;cancer therapy;Caregivers;Caring;Characteristics;Chronic;Cognitive;Cognitive Therapy;colon cancer patients;Conditioned Insomnia;Couples;Development;diaries;efficacy testing;experience;falls;Family;Family Caregiver;General Population;Health;Health Insurance Portability and Accountability Act;health practice;health related quality of life;Healthcare Systems;High Prevalence;high risk;Hour;human old age (65+);improved;improvement on sleep;indexing;Individual;individualized medicine;innovation;Intervention;intimate behavior;Investigation;Knowledge;Link;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Measurement;Measures;Medical;Middle Insomnia;Morbidity - disease rate;mortality;Nature;Observational Study;Outcome;Parameter Estimation;patient population;Patient Self-Report;Patients;phase III trial;Pilot Projects;Pittsburgh Sleep Quality Index;Point-of-Care Systems;Population;Population Heterogeneity;Prevention;primary outcome;Procedures;psychosocial;Public Health;Randomized;Reporting;Research;Research Design;Role;secondary outcome;Self Disclosure;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;social;Spouses;stressor;success;Survivors;Symptoms;telehealth;Testing;theories;trial design;Wrist

PROJECT_TITLE: Dyadic Sleep Intervention for Patients with GI Cancer and Their Caregivers

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE The digitization of health records and widespread availability of tumor DNA sequencing results offer a chance to better risk-stratify patients with implications for therapy selection, monitoring, and side effect mitigation. Here, we will test whether multimodal, artificial intelligence pipelines improve outcome modeling over standard predictors for patients with non-small cell lung cancer at three points: 1) Patients with localized disease at risk for relapse following definitive therapy, 2) Patients with oligometastatic disease considering consolidative radiotherapy, 3) Patients at risk for central nervous system disease who may benefit from MRI surveillance.

PI_NAMEs: JEE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Address;Adjuvant Chemotherapy;advanced disease;American Association of Cancer Research;American Joint Committee on Cancer;Antineoplastic Agents;Artificial Intelligence;Authorization documentation;Biological Assay;Biological Markers;burden of illness;Cancer Center;Cancer Relapse;cancer survival;career;Central Nervous System Diseases;Clinical;Clinical Data;Clinical Management;cohort;Computer software;Data;data curation;data modalities;Data Set;data streams;decision making algorithm;Diagnostic;Disease;Disease Surveillance;DNA Sequence Alteration;DNA sequencing;Doctor of Philosophy;empowerment;Environment;Faculty;Future;Genes;GENIE;genomic biomarker;genomic data;Genomic Instability;genomic profiling;Genomics;Goals;Head;health record;Home;Image;Immunotherapy;improved;improved outcome;innovation;insight;Institution;instructor;Lesion;liquid biopsy;Localized Disease;Lymph Node Involvement;Machine Learning;machine learning model;machine learning prediction;Magnetic Resonance Imaging;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Medical;Medicine;Mentorship;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to the Central Nervous System;Methods;Modality;Modeling;Monitor;multidimensional data;multidisciplinary;multimodal data;multimodal fusion;multimodal learning;multimodal modeling;multimodality;Mutation;Natural Language Processing;Nature;Non-Small-Cell Lung Carcinoma;Oncologist;Oncology;oncology service;Operative Surgical Procedures;Outcome;Patient Care;patient response;patient stratification;Patient-Focused Outcomes;Patients;Performance;Physicians;predictive modeling;Prior Therapy;Probability;prognostic;prognostic value;prognostication;Publishing;Qualifying;Radiation;Radiation therapy;radiological imaging;Radiology Specialty;radiomics;Recording of previous events;Recurrence;relapse prediction;relapse risk;Reporting;Reproducibility;Research;response;Risk;risk stratification;Sampling;Scientist;Selection for Treatments;side effect;Site;skills;Source;standard of care;structured data;surveillance imaging;survival prediction;tenure track;Testing;Text;Thoracic Oncology;Time;Tissues;Training;tumor;Tumor Biology;tumor DNA;tumor heterogeneity;tumor registry;Tumor Tissue;Tumor Volume;unstructured data

PROJECT_TITLE: Automatic integrated biomarkers to improve prediction of lung cancer outcomes

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Genetics;Infectious Diseases;Liver Disease;Microbiome

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Alteration of the gut microbiome associated with chronic diseases, known as dysbiosis, has been described in patients with cirrhosis. While many infectious complications of cirrhosis are thought to originate from the gut microbiota, the effects of dysbiosis on disseminated infections remain poorly understood. In this application, the candidate outlines a systematic approach to study the effect of lactulose, a common prescription for patients with cirrhosis, on bacterial growth in the microbiota and disseminated infection.

PI_NAMEs: HECHT, AARON L (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: acute liver injury;Award;Bacteremia;Bacterial Translocation;beta-Galactosidase;Bifidobacterium;Bioinformatics;Biological Models;Biology;Carbohydrates;Carbon;career;career development;Chronic Disease;Cirrhosis;Collaborations;Colon;comparative;Complication;constitutive expression;Data;derepression;Development;dietary;disease model;Doctor of Philosophy;dysbiosis;Engraftment;Enterobacteriaceae;Environment;Environmental Risk Factor;Enzymes;Escherichia coli;Escherichia coli Infections;Faculty;Family;Feces;fitness;Foundations;Funding;Future;gain of function mutation;Gastrointestinal Diseases;Genetic;Genomics;Goals;Growth;gut colonization;gut microbiome;gut microbiota;Hepatic Encephalopathy;Human;Human Biology;human subject;Infection;innovation;intestinal epithelium;Laboratories;Lac Operon;Lac Repressors;Lactobacillus;Lactose;Lactulose;Libraries;Liver diseases;Mediating;member;Metabolism;Microbiology;microbiota;mortality;mouse model;Mus;mutant;Mutation;novel;Operative Surgical Procedures;Operon;Organism;pathogen;pathogenic bacteria;Patients;Pennsylvania;Peritonitis;Phenotype;Physicians;Population;Positioning Attribute;Predisposition;Probiotics;Professional Competence;Regulation;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Scientist;Source;success;Techniques;tenure track;Testing;tool;Training;Transcription Regulatory Protein;Universities;Work

PROJECT_TITLE: Lac operon-dependent metabolism in Enterobacteriaceae and its role in liver disease-associated infections


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

PHR: Cognitive dysfunction in neuropsychiatric disorders such as schizophrenia predicts long-term disability and poor patient outcome and is not effectively treated with existing standard-of-care medications. This early conceptual stage R21 proposal builds the foundation of a preclinical drug development program for a new treatment approach to remediate the underlying imbalance in circuit activity to rescue cognitive function.

PI_NAMEs: KOH, MING TENG  (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Adolescence;aged;Brain;Calcium;Central Nervous System Diseases;Cognition;cognitive function;cognitive testing;Development;drug development;drug discovery;drug efficacy;efficacy evaluation;efficacy study;efficacy testing;Episodic memory;Fiber;Foundations;Functional disorder;Funding;Hippocampal Formation;Hippocampus;Homeostasis;Impaired cognition;improved;In Vitro;in vivo;in vivo evaluation;Individual;insight;Interneuron function;Intervention;Investigation;Kainic Acid;Ketamine;Lead;Long term disability;Measures;medial temporal lobe;Mediating;Memory;Monitor;multilevel analysis;neural;neuropsychiatric disorder;neuropsychiatry;novel;novel therapeutic intervention;novel therapeutics;Parvalbumins;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Photometry;positive allosteric modulator;pre-clinical;Preclinical Drug Development;Preparation;Program Development;Rattus;receptor;remediation;Research;response;restoration;Rodent;Schizophrenia;Series;Signal Transduction;small molecule;Source;standard of care;success;targeted agent;Therapeutic;Therapeutic Agents;therapeutic target;tool;translational potential;United States National Institutes of Health;Work

PROJECT_TITLE: A preclinical therapeutic platform to develop GABAA alpha5 receptor positive allosteric modulators to improve cognitive function in schizophrenia

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]