ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: The goals of this research are to characterize short-term versus long-term progressive biochemical and molecular indices of ethanol-induced cerebral white matter (WM) degeneration in relation to oligodendrocyte dysfunction. We propose that early abstinence-reversible adverse effects of ethanol on WM myelin are mediated by inflammatory and stress-induced increases in ceramide whereas more sustained chronic degeneration is due to impairments in insulin/IGF signaling through PI3K-Akt-mTOR with attendant compromises to oligodendroglial maturation, leading to pathogenic declines in sulfatide and increases in ceramide. We plan to assess therapeutic responses to abstinence, insulin sensitizers and inhibitors of ceramide biosynthesis in relation to stage of WM degeneration and cognitive impairment, and explore the degree to which co-existent PBMC membrane lipid abnormalities correlate with those present in WM as a potential non-invasive means of monitoring CNS WM degeneration and treatment responses.

PI_NAMEs: DE LA MONTE, SUZANNE M. (contact);SUTHERLAND, GREG TREVOR

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Abstinence;Acute;Address;Adverse effects;Agonist;Alcohol abuse;alcohol effect;alcohol exposure;alcohol monitoring;Alcohols;Anabolism;Atrophic;Autopsy;Axon;axon injury;axonal degeneration;binge drinking;Biochemical;Biological Assay;Brain;brain cell;Brain Diseases;Cell membrane;Cell Survival;cell type;Cellular Assay;Cellular Structures;Ceramides;Cerebrum;Chronic;Cognitive deficits;cognitive function;Data;Disease;effectiveness evaluation;Electron Microscopy;Ensure;enzyme activity;Enzyme-Linked Immunosorbent Assay;Enzymes;Ethanol;Exhibits;Experimental Models;experimental study;feeding;Female;FRAP1 gene;Functional disorder;Gene Expression;Goals;Homeostasis;Human;human model;Immunohistochemistry;Impaired cognition;Impairment;indexing;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Insulin;Insulin Antagonists;insulin sensitizing drugs;Insulin-Like Growth Factor I;Intervention;life span;Link;lipid metabolism;Lipid Peroxidation;Lipids;liver injury;Long-Term Effects;Maintenance;male;mass spectrometric imaging;Mediating;Membrane Lipids;Messenger RNA;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;Molecular Abnormality;molecular pathology;Monitor;Myelin;Nerve Degeneration;neurobehavioral;Neurocognitive;Neuronal Plasticity;Neurons;neurotoxic;non-invasive monitor;novel;Oligodendroglia;Oxidative Stress;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Peripheral Blood Mononuclear Cell;PIK3CG gene;Population;PPAR delta;prevent;Rattus;receptor;relative effectiveness;remediation;Reporting;Research;Research Design;response;restoration;Role;sex;Signal Pathway;Signal Transduction;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sphingolipids;Stress;Structure;Sulfoglycosphingolipids;Therapeutic;thermozymocidin;Time;tool;treatment response;treatment stratification;validation studies;white matter;white matter damage

PROJECT_TITLE: Pathogenesis of Early- Versus Late-Stage Alcohol-Mediated White Matter Degeneration


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Immunotherapy;Microbiome;Natural Products;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Pre-clinical Rheumatoid Arthritis (RA) is a period in which systemic autoimmunity develops in the years prior to onset of clinically apparent disease, which provides a window to intervene. While intestinal dysbiosis and altered tryptophan metabolism have been observed both in murine models of autoimmunity and in patients with rheumatic diseases, the mechanisms by which the microbiome and tryptophan metabolites may contribute to immune dysregulation have not been defined. Elucidating these mechanisms may therefore inform the development of future therapies to precisely target and/or modulate these pathways during pre-clinical RA.

PI_NAMEs: SEYMOUR, BRENDA J (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adoptive Transfer;Affect;Antibiotics;Antigen-Presenting Cells;antigen-specific T cells;Applied Skills;ATAC-seq;Autoimmunity;B-Lymphocytes;Bioinformatics;Bone Marrow;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Maturation;Cell Physiology;Cells;Clinical;Collagen;Collagen Arthritis;cytokine;Data;Dendritic Cells;design;Development;Diet;dietary;Disease;dysbiosis;effector T cell;experimental study;Fellowship;Flow Cytometry;Foundations;Future;Gene Expression Profile;Harvest;host microbiome;IL6 gene;Immune;Immunity;Immunology;Indoles;Inflammatory;Inflammatory Arthritis;insight;Interleukin-6;Intestines;Joints;Knowledge;Learning;Mediating;mesenteric lymph node;microbial;microbiome;microbiota;microorganism antigen;Modeling;mouse development;mouse model;Mucous Membrane;Mus;Neutrophil Activation;novel;Oral;Osteoclasts;Pathology;Pathway interactions;Patients;Phase;Play;Positioning Attribute;pre-clinical;prevent;Process;Production;Proliferating;Regulatory T-Lymphocyte;Research;Rheumatism;Rheumatoid Arthritis;Rheumatology;RNA;RNA analysis;Role;Serum;Signal Pathway;skills;Source;Spondylarthritis;Supplementation;systemic autoimmunity;T cell differentiation;T cell response;T-Cell Development;T-Cell Proliferation;Techniques;Testing;therapy design;Time;Tissues;Training;Transgenic Mice;Tryptophan;Tryptophan Metabolism Pathway;uptake;Work

PROJECT_TITLE: The role of indole-induced immune dysregulation in collagen-inducedarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Genetics;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: The goal of this project is to gain a better molecular understanding of breast cancer brain metastasis, a major cause of breast cancer death. This goal will be reached through using relevant models of breast cancer, including cell line-derived xenograft mouse models, PDXs, and newly generated transgenic mouse models. If successful, our project will provide major advances in breast cancer biology.

PI_NAMEs: LO, HUI-WEN  (contact);WATABE, KOUNOSUKE

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Alternative Splicing;angiogenesis;Astrocytes;autocrine;Brain;brain cell;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Cancer Biology;cancer cell;Cell Line;Cell secretion;Cessation of life;Clinical;cytokine;Data;Distant;ERBB2 gene;Exons;exosome;Family;Fatty acid glycerol esters;gain of function;Genes;GLI gene;Goals;Hand;Human;implantation;In Vitro;in vivo;Injections;insight;Invaded;knock-down;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;malignant phenotype;mammary;Mediating;Mediator;Metastatic malignant neoplasm to brain;Metastatic Neoplasm to Lymph Nodes;MicroRNAs;migration;Modeling;Molecular;monomer;Mouse Mammary Tumor Virus;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;neurotropic;novel;nucleocytoplasmic transport;Organ;overexpression;paracrine;Pathway interactions;patient derived xenograft model;Patients;Pattern;Play;Prognosis;Protein Isoforms;Proteins;Repression;Role;Route;Sampling;Sampling Studies;SHH gene;Signal Transduction;Stains;Testing;TP53 gene;transcription factor;Transcription Repressor;Transgenic Mice;Transgenic Organisms;tumor;tumor growth;Tumor Promotion;Up-Regulation;Validation;Xenograft procedure;Zinc Fingers

PROJECT_TITLE: Roles of tGLI1 and microRNA Network in Breast Cancer Brain Metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cancer

ORG_CITY: GAINESVILLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: TEAM-BASED INTERDISCIPLINARY CANCER RESEARCH TRAINING PROGRAM  PROJECT NARRATIVE Cancer is a major public health concern and training the next generation of cancer researchers is critical to the success of our national effort to improve cancer outcomes. We propose to develop a novel Team-based Interdisciplinary Cancer Research Training Program that will provide comprehensive training for both pre- doctoral and post-doctoral candidates by expert faculty members drawn from various scientific disciplines focused on cancer research. The Program is designed to build a group of rigorously trained, scientifically competent, and innovative young scientists who are qualified to lead interdisciplinary team-based research initiatives and have the skills to make a difference in the lives of individuals with cancer, population health, and cancer health policy through cutting edge research.

PI_NAMEs: SIEMANN, DIETMAR W (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: anti-cancer research;Training Programs

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative My recent publication demonstrated that caloric restriction significantly enhanced the function of memory T cells to provide protection against melanoma. While the molecular determinants and mechanisms remain unclear, my preliminary data suggests a direct role for acetate producing members of the intestinal microbiota. To determine factors and mechanisms that enhance the quality of memory T cells during CR could allow for the rational design and implementation of nutritional interventions to improve cancer immunotherapy.

PI_NAMEs: COLLINS, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acetates;Address;Adoptive Transfer;animal facility;Antitumor Response;Area;Autoimmunity;Bacterial Infections;Bifidobacterium;Bioinformatics;Caloric Restriction;cancer immunotherapy;cancer therapy;Cardiovascular Diseases;career;career development;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chromatin;Collaborations;Communication;Confocal Microscopy;CRISPR/Cas technology;Data;Development;Development Plans;Diet;Diet Modification;dietary;Dietary intake;Dietary Intervention;Digestion;Disease;Educational process of instructing;Enrollment;Environment;Epigenetic Process;experimental study;Fasting;Feedback;Flow Cytometry;Fostering;Gene Deletion;Gene Expression;Genes;genome-wide;germ free condition;Germ-Free;Gnotobiotic;Goals;gut microbiota;Health;Health Benefit;high standard;Histone Acetylation;Human;immune checkpoint blockade;Immune response;Immune system;immune system function;Immunologic Memory;Immunologics;immunoregulation;improved;In Vitro;Incidence;Infection;insight;Institution;instrument;Intestines;Laboratories;Lysine;Malignant Neoplasms;Maps;Mediating;Melanoma;member;Memory;Mentors;Mentorship;metabolic profile;microbial community;Microbiology;microbiota;Molecular;Molecular Biology;Monitor;Mus;Mutagenesis;Nerve Degeneration;novel;novel therapeutics;overexpression;Phase;Play;prevent;Process;Publications;Publishing;rational design;Research;Research Personnel;Resources;Retroviral Vector;RNA;Role;Scientist;Signal Pathway;single-cell RNA sequencing;Site;skills;Sorting;Specialist;synergism;T cell response;T memory cell;teacher;Techniques;Therapeutic;Therapeutic Uses;transcriptomics;tumor;tumor growth;United States National Institutes of Health;Vaccination;vaccine development;vaccine immunotherapy;Volatile Fatty Acids;Work;Writing;XCL1 gene

PROJECT_TITLE: Investigating the role of the microbiota in enhancing memory T cell function during caloric restriction to promote melanoma control

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Few treatments are available to treat neurodegenerative disease. Investigating the neuronal mechanisms that regulate neurodegeneration will address this critical need. In particular, identifying molecular pathways that protect the nervous system from degenerating will increase both our fundamental understanding of how degeneration is regulated and reveal future therapeutic targets to protect damaged and diseased axons.

PI_NAMEs: O'CONNOR, LAUREN  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acute;Affect;Animal Feed;Animals;Axon;axonal degeneration;Axotomy;Bacteria;Bioinformatics;Biological Assay;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;Chronic;Clinical;clinical candidate;cofactor;Comamonas;Data;Development;Diet;Disease;effective therapy;Environment;Escherichia coli;experimental study;Fatty Acids;fly;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic analysis;Genome;Genotype;Goals;gut microbiota;gut-brain axis;Homocysteine;human disease;Image;Impaired cognition;in vivo;Injury;innovation;Institution;Lasers;life span;Mediating;Mentorship;Methionine;Methylmalonyl-CoA Mutase;microbiome;Modeling;Molecular;Motor;motor neuron degeneration;Mus;mutant;Nematoda;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;Neurons;neuroprotection;overexpression;Pathway interactions;Physiology;Play;prevent;Principal Investigator;programs;protective pathway;Reproduction;Research;response;Role;Signal Transduction;skills;Therapeutic;therapeutic target;Tissues;Training;Vitamin B 12

PROJECT_TITLE: Investigating Mechanisms of Neurodegeneration


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

PHR: We aim to determine the cellular and physiological functions of TMEM106B and its role in FTLD using cell culture and mouse models as well as postmortem human patient samples.

PI_NAMEs: HU, FENGHUA  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Ablation;Affect;age related;Aging;aging brain;Alzheimer's Disease;Autophagocytosis;Autopsy;Axon;base;Biochemical;Biological;Brain;Brain Diseases;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;Collaborations;Defect;Development;Disease;Disease Progression;Distal;druggable target;Exhibits;Exocytosis;Fibroblasts;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Genetic;glial activation;Gliosis;granulin;Human;In Vitro;in vivo evaluation;insight;Integral Membrane Protein;late endosome;leukodystrophy;limbic-predominant age-related TDP-43 encephalopathy;Lysosomes;Membrane Proteins;Modeling;Molecular;motor disorder;mouse model;Movement;Mus;Mutation;Myelin;Myelin Sheath;myelination;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neuron loss;novel;Nuclear;oligodendrocyte progenitor;Oligodendroglia;Organism;Parkinson Disease;Pathology;Patients;Phenotype;Phosphorylation;Physiological;Positioning Attribute;protein protein interaction;protein TDP-43;Proteins;Proteomics;Regulation;Risk;Risk Factors;risk variant;Role;Sampling;Structure;TDP-43 aggregation;Testing;trafficking;Work

PROJECT_TITLE: Function of TMEM106B in Neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Immunization;Immunotherapy;Prostate Cancer;Urologic Diseases;Vaccine Related

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative We have recently demonstrated a new concept, the use of oxygen-generating biomaterials to overcome hypoxia- driven immunosuppression in tumor cell vaccines and improve therapeutic efficacy. This proposal will optimize these vaccines to enhance antitumor immune responses and test their ability to prevent the growth of and treat metastatic prostate cancer in relevant mouse models. Successful completion of these studies may have a sustained impact on the field by defining a new avenue of cancer immunotherapy that operates independently but synergizes with other existing therapies for the treatment of human cancer.

PI_NAMEs: HATFIELD, STEPHEN MATTHEW (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Address;Adjuvant;American;anti-tumor immune response;Antigen-Presenting Cells;Antitumor Response;Autologous Tumor Cell;Automobile Driving;Biocompatible Materials;biomaterial compatibility;Breast Cancer Model;Cancer Etiology;cancer immunotherapy;cancer recurrence;cancer vaccination;Cancer Vaccine Related Development;Cancer Vaccines;CD8B1 gene;Cell Physiology;Cells;Cessation of life;Characteristics;Clinical;combat;Cross-Priming;cryogel;Data;Dendritic cell activation;Dendritic Cells;Distant Metastasis;Dose;draining lymph node;Engineering;Environment;Exhibits;experimental study;functional restoration;Future;Growth;Homing;Human;Hyaluronic Acid;Hypoxia;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune system;immunogenic;Immunologic Tests;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Injectable;innovation;insight;Irradiated tumor;Laboratories;lymph nodes;Malignant neoplasm of prostate;Malignant Neoplasms;Mechanics;Mediating;men;Metastatic Prostate Cancer;migration;mouse model;Mus;Neoplasm Transplantation;neoplastic cell;novel;Outcome;Oxygen;particle;Patient-Focused Outcomes;Patients;Peripheral;personalized cancer therapy;Play;polymerization;Polymers;Porosity;Positioning Attribute;prevent;Primary Neoplasm;Property;prophylactic;prostate cancer model;Prostate Cancer therapy;Prostatic Neoplasms;recruit;Research;response;Role;Safety;scaffold;Site;Specificity;Stress;supplemental oxygen;synergism;Syringes;T cell response;T memory cell;T-Lymphocyte;Temperature;Testing;Therapeutic;tool;Toxic effect;Transplantation;Treatment Efficacy;tumor;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;vaccine efficacy;Vaccines

PROJECT_TITLE: Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Many patients with blood cancers (leukemias) are treated with a blood stem cell transplant from another person. Much of the benefit of such transplants are from donor immune cells that attack the leukemia cells. However, some types of leukemias benefit more so than other types from this immune effect. In prior work we discovered that leukemias that benefit less need a substance called interferon-gamma in order for them to be killed by the immune cells. In this proposal we test whether this is true for a broader range of leukemias and investigate exactly how interferon-gamma works to sensitize leukemias to immune cell killing. This knowledge could make blood stem cell transplants more effective.

PI_NAMEs: SHLOMCHIK, WARREN D (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Affinity;Alloantigen;Allogenic;Allografting;Biological Models;Biology;Blast Phase;Bone Marrow Cells;Cause of Death;CD8B1 gene;cell killing;Cells;cellular transduction;Chronic-Phase Myeloid Leukemia;Clinic;Clinical;clinical application;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;CSPG6 gene;curative treatments;Cytomegalovirus;Data;DNMT3a;Donor person;experimental study;Failure;FLT3 gene;Future;Gene Deletion;Gene Expression;Genes;Genetic;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Heterogeneity;HOXA9 gene;Human;IFNGR1 gene;Immune;Intercellular adhesion molecule 1;Interferon Type II;Interferons;Knock-in;Knock-out;Knockout Mice;Knowledge;KRAS2 gene;leukemia;leukemia relapse;Leukemic Cell;Mediating;minor H antigen H60;Minor Histocompatibility Antigens;MLL-AF9;Modeling;Molecular Abnormality;molecular subtypes;mouse model;Mus;Natural Killer Cells;Neoplasms;NUP98 gene;Oncogenes;overexpression;Patients;Persons;Phenocopy;pleiotropism;post-transplant;Property;Recurrent disease;Relapse;Resistance;Role;single-cell RNA sequencing;Specimen;STAT1 gene;STAT2 gene;Stem cell transplant;stem cells;T cell response;T cell therapy;T-Lymphocyte;Testing;therapeutic target;tool;TP53 gene;Transplantation;Work

PROJECT_TITLE: Mechanisms whereby IFN-gamma sensitizes AML to the graft-vs-leukemia effect

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT Humans and mice have very limited potential for scar-free repair or regeneration of adult tissues. Recent work in mice has identified components of the immune system as negative regulators of regeneration that can restrict adult regeneration. This project will identify the critical biological pathways required to develop new strategies to transiently modify components of the immune system with the goal of inducing the latent regenerative potential in mammals and thereby significantly improving human health.

PI_NAMEs: GODWIN, JAMES W (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Ablation;Adult;Amphibia;Amputation;Anatomy;Antigens;Apoptosis;Beds;Biological;Biological Assay;Biological Response Modifiers;bone;cancer cell;cancer risk;CD47 gene;cell type;Cells;Cessation of life;Cicatrix;clinical application;Cytoprotection;cytotoxic;cytotoxicity;Development;Developmental Biology;digit regeneration;Digit structure;Distal;Down-Regulation;Embryo;endogenous stem cells;Environment;Excision;Failure;FOXP3 gene;Future;Gene Modified;Genes;Genetic;Goals;Health;Healthcare;Healthcare Systems;healthspan;Histology;HLA G antigen;Human;human tissue;Immune;Immune system;Immunity;Immunologics;immunoregulation;Immunosuppression;Immunotherapy;Impact evaluation;improved;in utero;In Vitro;in vivo;in vivo evaluation;in vivo regeneration;infection risk;Joints;Knowledge;Life;life span;Limb Bud;limb injury;limb loss;limb regeneration;Limb structure;Location;Lymphocyte;Lymphoid;Lymphoid Cell;Mammals;Measures;Mediating;Methods;microCT;Modeling;Molecular;Molecular Analysis;Mouse Strains;Mus;Mutation;Nail plate;Natural Killer Cells;Natural regeneration;nectin;novel;Organ;overexpression;Pathway interactions;Patients;Phalanx;Phenotype;Play;Positioning Attribute;progenitor;programmed cell death ligand 1;programs;public health relevance;receptor;Receptor Inhibition;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regenerative pathway;Regenerative research;Regenerative response;regenerative therapy;Regulation;Regulatory T-Lymphocyte;repaired;Resolution;response;Role;Salamander;Societies;soft tissue;stem;stem cell niche;stem cell proliferation;stem cells;Structure;success;Supporting Cell;Surface;T-Lymphocyte;Testing;Therapeutic;Three-Dimensional Imaging;Thymus Gland;tissue repair;Tissues;TNFSF10 gene;transgene delivery;Transgenic Organisms;translational study;Viral;Viral Genes;Work;wound;wound healing

PROJECT_TITLE: DISARMing the immunological barriers to regeneration in mammals

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE This study aims to develop an Automated RIsk Assessment (ARIA) system to analyze participant interviews, detect students at elevated risk of school violence, and provide risk characteristics to assist prevention. The proposed research is relevant to public health because developing an ARIA system will help establish a nationwide solution for detecting and preventing school violence. The objectives of this proposal are consistent with NICHD's high-priority research areas that aim to develop new knowledge about the identification, etiology, early intervention, and mechanisms of violence from childhood through early adulthood.

PI_NAMEs: BARZMAN, DREW  (contact);DEXHEIMER, JUDITH W.

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Achievement;Adolescent;Aggressive behavior;Area;Attitude;automated assessment;Behavior;bullying;Characteristics;Childhood;Clinical;clinical practice;computerized;cost;Crime;Data;Data Set;deep learning model;Descriptor;design;Development;Dropout;Early Intervention;emerging adult;Etiology;Evaluation;experience;Family;Feeling;follow-up;Foundations;Geographic Locations;Goals;Health Benefit;Healthcare;high risk;impression;improved;Impulsivity;Individual;individualized prevention;innovation;Institution;Interview;Judgment;Knowledge;Language;Legal Guardians;Linguistics;Machine Learning;machine learning prediction;Manuals;Medical center;Methods;National Institute of Child Health and Human Development;Natural Language Processing;Observational Study;Outcome;participant interview;Pediatric Hospitals;Performance;Population;predictive modeling;prevent;Prevention;Prevention program;Process Assessment;Property;prospective;Psychiatrist;Public Health;Qualifying;Questionnaires;Randomized;Recommendation;recruit;Reporting;Research;Research Priority;Risk;Risk Assessment;Risk Factors;risk prediction;ROC Curve;Safety;Sampling;school violence;school violence prevention;Schools;Scientist;screening;Site;Structure;Students;study population;System;Technology;Testing;Thinking;Training;Universities;Validation;Violence;Work;Youth;youth violence

PROJECT_TITLE: Automated Risk Assessment for School Violence Prevention

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Estrogen;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The transcriptional reactivation of endogenous retroviruses and retrotransposons beyond a threshold level of tolerance in cancer cells stimulates intracellular viral defense pathways that can promote antitumor effects and augment the effectiveness of certain cancer therapies. This therapeutic approach, termed viral mimicry, could hold promise for the treatment of advanced estrogen receptor (ER)+ breast tumors that often develop resistance to hormone-based therapies and recur years or even decades post-diagnosis. Understanding how SUV39H1 targeting induces viral mimicry selectively in ER+ breast cancer cells could lead to a safe and effective therapeutic approach to prevent metastatic recurrences and extend the utility of immune checkpoint blockade (ICB) and PARP inhibitor therapies to this tumor subtype, undoubtedly leading to a significant reduction in disease mortality.

PI_NAMEs: SPRUCK, CHARLES H. (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Activated Natural Killer Cell;antitumor effect;Binding;Biological Assay;bone;Bone Metastases Prevention;brca gene;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cancer therapy;Cells;chemotherapy;Chromatin Remodeling Factor;Clinical;clinical application;Clinical Trials;Complex;cytotoxic;Cytotoxic T-Lymphocytes;Data;Detection;Development;Diagnosis;Disease;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA replication fork;DNA Replication Induction;DNA Single Strand Break;Effectiveness;Endogenous Retroviruses;Epigenetic Process;Estrogen Receptors;Estrogen Therapy;Gene Silencing;Genetic Transcription;Genetically Engineered Mouse;genome integrity;Goals;Growth;Histone Deacetylase;Histone H3;homologous recombination deficiency;Hormones;Human;Human Genome;Immune;immune checkpoint blockade;immunogenicity;Immunotherapy;in silico;Infiltration;inhibitor;inhibitor therapy;Interferons;Ligands;Lysine;Malignant Bone Neoplasm;Malignant Breast Neoplasm;Mammary Neoplasms;Mediating;Metastatic Neoplasm to the Bone;Metastatic/Recurrent;Methylation;Methyltransferase;mimicry;Molecular;mortality;mouse model;Mus;mutant;Mutation;Natural Killer Cells;Normal Cell;Nucleosomes;NuRD complex;Organ;Pathway interactions;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;preclinical study;prevent;Proteins;recruit;Recurrence;Refractory;Relapse;Repetitive Sequence;replication stress;Resistance development;Retrotransposon;RNA interference screen;Signal Transduction;Somatic Cell;Stimulator of Interferon Genes;synergism;Therapeutic;therapeutically effective;Transcriptional Silencer Elements;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Subtype;Tumor-Infiltrating Lymphocytes;Tumorigenicity;ubiquitin ligase;Viral

PROJECT_TITLE: Targeting ER+ Breast Cancer Through Induced Viral Mimicry


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Most patients with late-life onset Alzheimer's disease (AD) have cerebral small vessel ischemic disease; currently, there is no treatment or effective prevention strategies. We will focus on a specific endocrine hormone, which when hypersecreted, causes diabetes and interaction with AD pathology. If our study demonstrates that the specific hormone we are studying causes cerebral small vessel disease, then new inhibitors of this hormone should help protect the brain in aging and diabetes.

PI_NAMEs: DESPA, FLORIN  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acceleration;Acids;Adherence;Adhesions;age acceleration;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Arteries;axonal degeneration;Behavioral;beta amyloid pathology;Blood;Blood capillaries;Blood Vessels;Brain;brain cell;brain dysfunction;Cardiovascular system;Carrying Capacities;cerebral capillary;Cerebral small vessel disease;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular system;Cerebrum;Clinical Data;clinical translation;cohort;comorbidity;Data;Dementia;Deposition;Development;Diabetes Mellitus;Disease;Disease Marker;effective therapy;Endocrine;Enrollment;Enzymes;Epoxide hydrolase;Erythrocytes;Feasibility Studies;Genetic;Gliosis;Glucose;Hemoglobin;Hemorrhage;Hormone Antagonists;Hormones;Human;Hypersensitivity skin testing;Hypoxia;hypoxic ischemic injury;Hypoxic-Ischemic Brain Injury;Impaired cognition;in vivo;Individual;inhibitor;innovation;Insulin;Ischemia;islet amyloid polypeptide;Isomerism;Laboratories;late life;Link;Magnetic Resonance Imaging;Measures;Mediating;Mediator;Metabolic dysfunction;Microspheres;mild cognitive impairment;Modeling;National Institute of Neurological Disorders and Stroke;neuroinflammation;Neurologic Deficit;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Outcome;Pancreas;Participant;Pathologic;Pathologic Processes;Pathology;Patients;pharmacologic;Phenotype;Prevention;Prevention strategy;protective pathway;Proteins;Rattus;Regulation;Reporting;Research Project Grants;Sampling;Satiation;Senile Plaques;Signal Pathway;Skin;skin biopsy;tau Proteins;Techniques;Testing;Therapeutic Intervention;tool;translational study;Vascular Cognitive Impairment;vascular cognitive impairment and dementia;Vascular Endothelial Cell

PROJECT_TITLE: The Amylin Dyshomeostasis Hypothesis of Vascular Contributions to Cognitive Impairment and Dementia (VCID)

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Radon is a colorless, odorless, toxic radioactive gas and radon exposure is rising steadily within the modern North American residential environment. The proposed study aims to examine the association between radon exposure and stroke risk and to investigate whether the distribution of radon concentration is a reason for the racial and geographic variations of stroke rate in the US. Since randomized clinical trials on radon exposure is not feasible, findings from this study will provide crucial information to help identify a potential modifiable common risk factor for stroke.

PI_NAMEs: KAHE, KA  (contact);SMITH, BRIAN JOSEPH

PROGRAM_OFFICER_NAME: JETT, DAVID ALAN

PROJECT_TERMS: absorption;Adult;African American;African American Women;aged;Air;American;Ancillary Study;Area;Arteries;Attention;Biological Markers;Blood;Blood Pressure;Blood Vessels;Brain;burden of illness;C-reactive protein;Carcinogens;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Caucasians;Cause of Death;Child;Classification;cohort;Country;County;Data;design;Diet;disability;Disease;Environment;Environmental Risk Factor;Event;Exposure to;Factor VIII;Fibrin fragment D;Gases;General Population;geographic difference;Geographic Factor;Geography;Goals;Health;Health care facility;health care quality;Hemostatic Agents;Home;Hour;Household;Human;Hypertension;Individual;Infection;Inflammation;Inflammatory;Inhalation;insight;International Agency for Research on Cancer;Ischemic Stroke;Life Style;Link;Lipids;low socioeconomic status;Lung;male;Malignant neoplasm of lung;Measures;Metabolic Diseases;Minor;Modernization;modifiable risk;mortality;never smoker;Oxidative Stress Induction;Participant;particle;Pathologic;Pattern;Penetration;population based;Prevention;Publishing;Race;Radioactive;Radium;Radon;Random Allocation;randomized, clinical trials;Reactive Oxygen Species;Reasons for Geographic And Racial Differences in Stroke;Research;Research Personnel;Resistance;Risk;Risk Factors;Smoking;Stream;Stroke;stroke risk;Time;Tissues;Tobacco smoking behavior;United States Environmental Protection Agency;Variant;Veins

PROJECT_TITLE: Residential Radon Exposure and Stroke Risk: the REGARDS Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-K(02)M]


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Genetics;Infertility;Polycystic Ovary Syndrome (PCOS);Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Polycystic ovary syndrome (PCOS) is the most common form of annovulatory infertility of reproductive age women affecting 5-10% of reproductive age women and contributing >$5 billion to the healthcare burden in the US annually. We have identified functional variants in the AMH and AMHR2 genes that are very strongly associated with PCOS and identify a PCOS sub-phenotypic. The goal of this proposal is to identify the function of PCOS causal variants in the broader AMH signaling pathway which will explain the molecular basis and phenotypic heterogeneity of PCOS and the successful implementation of Precision Medicine.

PI_NAMEs: URBANEK, MARGRIT  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Age;Amenorrhea;AMHR2 gene;Androgens;anovulatory infertility;Antral;Aromatase;biobank;Bioinformatics;Biological Assay;Biological Markers;Candidate Disease Gene;Catalogs;causal variant;Code;cohort;Complex;CYP11A1 gene;CYP17A1 gene;Data;dehydroepiandrosterone;Development;Disease;disorder risk;Down-Regulation;Electronic Medical Records and Genomics Network;Endocrine;epigenetic variation;Estradiol;Estrone;Etiology;European;Evaluation;Female;folliculogenesis;Follow-Up Studies;Gene Expression Profile;Gene Frequency;General Population;Genes;Genetic;genetic approach;Genetic Databases;Genetic Transcription;genetic variant;Genetic Variation;genome sequencing;Goals;granulosa cell;Growth;healthcare burden;Heritability;Heterogeneity;Hormonal;Hormones;Hyperandrogenism;Impairment;improved;in silico;Infertility;innovation;Insulin Resistance;Link;loss of function;Maps;Medical center;Medical Records;member;men;Metabolic;Microfluidics;Minor;Missense Mutation;Molecular;mRNA Expression;mullerian-inhibiting hormone;Mullerian-inhibiting substance receptor;multi-ethnic;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oligomenorrhea;Organ Model;Ovarian;Ovarian Follicle;Participant;Periodicity;Phenotype;Polycystic Ovary Syndrome;population based;population health;precision medicine;Prevalence;Production;Progesterone;protein expression;receptor;recruit;Regulation;Regulatory Element;Reporting;Reproduction;reproductive;Risk;Role;Signal Transduction;Signaling Protein;Steroid biosynthesis;support network;Syndrome;Targeted Resequencing;Testing;Testosterone;theca cell;Tissues;United States National Institutes of Health;Untranslated RNA;Variant;whole genome;Woman

PROJECT_TITLE: AMH signaling pathway variation in PCOS

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: Project Narrative Transgender and nonbinary (TNB) people are highly vulnerable to HIV and have lower use of pre-exposure prophylaxis (PrEP) for HIV prevention. This project will optimize and test a flexible trans-friendly clinic model for delivering long-acting injectable PrEP with CAB-LA, a recently approved medication that could greatly increase continued use of PrEP in TNB people. This study will also test for drug interactions between gender affirming hormones and CAB-LA, an important question that needs to be addressed for the TNB community.

PI_NAMEs: LIU, ALBERT YING-HWA (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Affect;AIDS prevention;Area;Area Under Curve;Awareness;Black race;cis-male;Clinic;Clinic Visits;Clinical;cohort;Communities;community clinic;Consolidated Framework for Implementation Research;cost;Coupled;Data;Disparity;Drug Interactions;Drug Kinetics;drug testing;Education;Enrollment;Ensure;Epidemic;Estradiol;Evidence based intervention;Feedback;flexibility;Friends;Frontline worker;gender affirmation;gender affirming hormone therapy;gender affirming hormones;General Population;Health Professional;high risk;HIV;HIV diagnosis;HIV disparities;HIV Infections;Hormones;Hour;implementation outcomes;implementation strategy;improved;Individual;Infection;informant;Injectable;Injecting drug user;Injections;Insurance;interest;intersectionality;Interview;Latinx;Marketing;Measurement;Medical;Medical Records;men who have sex with men;Methods;Modeling;Monitor;Newly Diagnosed;nonbinary;novel;novel strategies;Nurses;Oral;Participant;Patients;peer;people of color;Persons;Pharmaceutical Preparations;pill;Pilot Projects;Plasma;Population;practice setting;pre-exposure prophylaxis;Prevalence;primary care clinic;primary care setting;Process;programs;Protocols documentation;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Methodology;San Francisco;Scientific Advances and Accomplishments;Series;sex;Sexual Partners;Spanish/English;Structure;Surveys;Testing;Testosterone;texting support;transgender;transgender men;transgender women;Transportation;United States;uptake;Vulnerable Populations;Work

PROJECT_TITLE: The Bridge Clinic: Optimizing Injectable PrEP Delivery for Transgender and Non-Binary People


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project narrative Select organisms are capable of regenerating an entirely new body during adulthood. This research program aims to reveal the pathways and principles controlling whole body regeneration in the planarian flatworm Schmidtea mediterranea and the distantly related acoel Hofstenia miamia. These strategies seek to understand the conserved and uniquely evolved spatial information systems and regulatory mechanisms that can enable regenerative growth.

PI_NAMEs: PETERSEN, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Adult;adult stem cell;Biological Models;Cell Count;Cell Differentiation process;Developmental Process;Distant;Event;Expression Profiling;Grant;Growth;Homeostasis;Information Systems;Injury;injury and repair;Maintenance;Modeling;Molecular;Natural regeneration;Organism;Outcome;Pathway interactions;Planarians;Platyhelminths;Process;programs;regenerative;regenerative growth;regenerative tissue;Regulation;Research;response;restoration;RNA interference screen;Role;Signal Induction;Signal Transduction;Source;stem cells;System;tissue repair;Tissues;transcriptomics;Work;wound

PROJECT_TITLE: Regulation of whole-body regeneration

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: This work represents a novel exploration of individual differences in reading ability in both children and adults, with the goal of understanding which factors lead to poor comprehension. Low literacy attainment is linked with poor health outcomes and increased levels of infant and child mortality in the population (DeWalt & Pignone, 2005), and is even more closely associated with poor health than the number of years of school completed (Baker et al., 1996).

PI_NAMEs: WATSON, DUANE G (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 8 year old;Address;Adult;Age;aged;Agreement;Child;Child Mortality;Cognition;Cognitive;cognitive ability;cognitive skill;college;Communication;Complex;Comprehension;comprehension skill;Development;Economics;Education;experience;experimental study;Goals;Health;health care availability;improved;Individual;Individual Differences;Infant Mortality;innovation;Instruction;Intervention;Language;language comprehension;language processing;Lead;Link;literacy;Literature;Low Income Population;Measures;Methodology;Minority;Nature;Newspapers;novel;Outcome;phonology;poor health outcome;Population;Predictive Factor;processing speed;programs;Psycholinguistics;Reader;Reading;reading ability;Research;Research Personnel;Role;Schools;Series;Short-Term Memory;skills;Structure;syntax;Testing;Text;Textbooks;theories;Time;Work

PROJECT_TITLE: The Role of Cognitive Skills and Language Experience in Grammatical Processing

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

PHR: Project Narrative Relative to other racial/ethnic groups, Southeast Asian (SEA) children (specifically Hmong, Cambodian, Vietnamese and Laotian) experience higher rates of diet-related chronic diseases like type 2 diabetes risk factors. We will leverage our a longstanding partnership with the Center for SEA to test the feasibility and preliminary efficacy of an innovative multilevel, multicomponent, multigenerational dietary intervention with SEA families with children ages 6 to 11. This intervention integrates family-based nutrition education, motivational interviewing, descriptive dietary norms messaging, and healthy eating financial incentive coupons to improve children’s diet quality (primary) and body mass index and HbA1c (secondary).

PI_NAMEs: GANS, KIM M.;KEITA, AKILAH JOYCE;TOVAR, ALISON  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Adult Children;Affect;Age;arm;Asian;Asian Women;attentional control;Behavior;behavior change;Behavioral;Body mass index;Body Weight decreased;Cambodian;Carotenoids;Child;Child Health;Child Nutrition;Chronic;Chronic Disease;Clinical;Clinical Trials;Communities;community academic partnership;community clinic;Community Health Aides;Community Healthcare;community intervention;County;Dermal;design;Diet;dietary;Dietary Intervention;Dietary Practices;Disease;Disparity;Disparity population;Dose;early onset;Education;effective intervention;efficacious intervention;Emotions;energy balance;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Population;Exhibits;experience;Family;Fatty acid glycerol esters;Feasibility Studies;feasibility testing;feasibility trial;Feedback;financial incentive;Food;Food Access;food environment;Frequencies;Funding;Future;Gestational Diabetes;Glycosylated hemoglobin A;Goals;good diet;grandparent;Guilt;health disparity;health disparity populations;Health Food;Healthy Eating;Height;high risk;Home;implementation fidelity;implementation framework;implementation intervention;improved;indexing;Individual;innovation;Insulin Resistance;intergenerational;Intervention;intervention refinement;Intervention Studies;Measures;Methods;Mission;Modeling;motivational enhancement therapy;multi-component intervention;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;nutrition education;Obesity;Outcome;Parents;Participant;Philosophy;Pilot Projects;Poverty;Prevalence;prevent;primary outcome;process evaluation;Publishing;Race;racial minority;racial population;Randomized;recruit;Reducing diet;Refugees;Research;Rhode Island;Risk;Risk Factors;Scientific Advances and Accomplishments;secondary outcome;social;social cognitive theory;southeast Asian;stem;Structure;Subgroup;sugar;Telephone;Testing;Text Messaging;Training;transmission process;Trauma;treatment arm;Treatment Efficacy;Unhealthy Diet;Vietnamese;waist circumference;Weight Gain;White Women;Work

PROJECT_TITLE: Testing a Multilevel, Multicomponent, Multigenerational Dietary Intervention to Improve Southeast Asian Children's Diets

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-B(02)]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative The Expanding the Pipeline to Graduate Research in Alzheimer’s Disease and Related Dementias (EPGRAD) Program is an intensive two-month summer training experience for undergraduates from diverse backgrounds that will encourage students to pursue graduate study and careers in research on aging and Alzheimer’s disease and related dementias (ADRD) – thus increasing the diversity and inclusivity of the research workforce in these areas. The program will blend didactic training in epidemiological research methods and introductory data science methods with hands-on mentored research experiences in the area of ADRD. In addition to these experiences, trainees will participate in graduate school and career counselling sessions, journal club meetings, cutting-edge research seminars, and social activities that will serve to foster skills development and interest in aging and ADRD.

PI_NAMEs: APARICIO, HUGO JAVIER;CIARLEGLIO, ADAM  (contact);DEVINE, SHERRAL A.

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Age;Aging;aging brain;Alzheimer's disease related dementia;American;Area;Boston;brain health;career;Caring;cohort;Collaborations;Data Science;Dedications;Dementia;disadvantaged background;diversity and inclusion;economic disparity;Education;epidemiology study;ethnic diversity;ethnic minority;ethnic minority population;Evidence based practice;experience;Faculty;Fostering;Foundations;Framingham Heart Study;Goals;graduate school;human old age (65+);Institution;interest;Journals;Knowledge;Learning;meetings;Mentors;Mentorship;Methods;Participant;Population;Population Heterogeneity;posters;prevention practice;programs;public health research;racial diversity;racial minority;racial minority population;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;skill acquisition;skills;social;Solid;Structure;Students;summer program;summer research;teacher;Training;training opportunity;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Vocational Guidance;Washington;Work

PROJECT_TITLE: Expanding the Pipeline to Graduate Research in Alzheimer's Disease and Related Dementias (EPGRAD) Program


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative: These studies will investigate the molecular mechanisms for how the expression of human genes are turned off and on by cellular machinery. New chemical methods will be developed and applied to elucidate these gene regulation mechanisms and our findings can lead to new strategies for the diagnosis and treatment of many diseases including cancer.

PI_NAMEs: COLE, PHILIP A (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Acetyltransferase;analog;Biochemical;Biology;cell type;Cells;Chemicals;Chromatin;combat;Complex;Deacetylase;demethylation;design;Development;Diagnosis;Disease;diversity and inclusion;Engineering;Enzymes;EP300 gene;Epigenetic Process;experimental study;Gatekeeping;Gene Expression;Gene Expression Regulation;Gene Silencing;Generations;Genes;HDAC1 gene;Histone H3;histone modification;Histones;Human;inhibitor;innovation;interest;KDM1A gene;Knowledge;Ligation;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;Methods;Modification;Molecular;National Institute of General Medical Sciences;next generation;novel therapeutic intervention;Nucleosomes;Paste substance;Pattern;pharmacologic;Phase;Post-Translational Protein Processing;PRC1 Protein;pre-clinical;Predisposition;Production;programs;Protein Isoforms;Proteins;Proteomics;Research;Research Personnel;response;SAGA;Science;Site;sortase;Tail;Therapeutic;Training;ubiquitin isopeptidase;Writing

PROJECT_TITLE: Chemical Approaches to Understanding Reversible Lysine Modifications


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative There are currently over 12 million Americans suffering from diseases affecting the retina, for which therapeutic attempts at repair or regeneration have been met with limited success. The zebrafish is an organism that exhibits remarkable capacity for retinal regeneration upon significant injury with no evidence of scarring, however many of the mechanisms behind this process remain poorly understood. With the experiments outlined in this proposal, we aim to determine the role of DNA methyltransferases in regulating the epigenetic control of retinal regeneration in the zebrafish as well as develop a targeted epigenetic modulation tool that may open new avenues for therapeutic approaches in mammalian retinal injury.

PI_NAMEs: KRAMER, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Adult;adult stem cell;Affect;American;Anatomy;beta catenin;Candidate Disease Gene;Cell Cycle;Cell Differentiation process;cell growth regulation;Cell Physiology;cell type;Cells;Cessation of life;Characteristics;Cicatrix;Communities;Comparative Biology;CRISPR/Cas technology;Data;demethylation;Development;Disease;DNA;DNA Methylation;DNA Modification Methylases;Down-Regulation;Economic Burden;Epigenetic Process;epigenetic regulation;Exhibits;experimental study;Funding;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Gliosis;Goals;Government;Hematopoietic stem cells;Hour;In Vitro;in vivo;in vivo evaluation;Individual;Induced Neurons;Injury;Investigation;knock-down;Knock-out;Literature;Maintenance;Mammals;Mediating;Methods;Modeling;Modification;Molecular;Morphology;Muller's cell;Multipotent Stem Cells;National Eye Institute;Natural regeneration;Neuroglia;Neurons;Organism;Outcome;Pathway interactions;Phenotype;pluripotency;Process;progenitor;promoter;regenerative;Regenerative Medicine;repaired;Research;response;Retina;retinal damage;Retinal Diseases;retinal regeneration;Role;Sequence Homology;Signal Pathway;Signal Transduction;Stem Cell Development;stem cell proliferation;stem cells;success;System;targeted treatment;Techniques;teleost;Testing;Therapeutic;Time;timeline;tissue regeneration;Tissues;tool;transcription factor;Translating;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Elucidating the role of DNA methyltransferases in epigenetic regulation of retinal regeneration in zebrafish

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Parkinson disease (PD) is a progressive, disabling neurological disorder, but the impact of the disease on Black patients with PD is unclear due to less research in this population. This study investigates racial disparities by studying symptoms and signs, management, and genotype relationships in Black PD participants in comparison to a group of White PD participants. This study will result in new scientific knowledge regarding PD in the Black population by characterizing the basis for racial disparities, raising awareness of differences in PD recognition and management, and educating patients in this underserved and understudied population.

PI_NAMEs: HALL, DEBORAH A (contact);SHULMAN, LISA M.

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Address;Affect;African ancestry;Awareness;black patient;Black Populations;Black race;Caring;Characteristics;Clinical;clinical diagnosis;Clinical Management;clinical phenotype;clinical practice;clinical research site;Clinical Trials;Cognition;Cognitive;cohort;Cohort Studies;Collaborations;Communities;Data;Diagnosis;disability;disabled;Disabling;Disease;disease heterogeneity;disease phenotype;disorder risk;Disparity;disparity reduction;Education;empowerment;European ancestry;Fostering;Foundations;Frequencies;Functional disorder;functional outcomes;Future;Genetic;genetic analysis;genetic architecture;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic variant;Genetic Variation;genomic variation;Genotype;Geographic Locations;Goals;Guidelines;health care delivery;health disparity;health goals;Health Services Accessibility;Heritability;illness length;Improve Access;improved;Incidence;Individual;Intervention;intervention cost;Knowledge;Life Experience;Measures;Mental Depression;Mental Health;Methodology;Motor;motor disorder;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;novel;Operative Surgical Procedures;Parkinson Disease;Participant;Patient Outcomes Assessments;Patient Recruitments;patient stratification;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;phenotypic data;Population;Predisposition;programs;prospective;Public Health;Quality of Care;Quality of life;racial difference;racial disparity;recruit;Rehabilitation therapy;Research;Research Priority;risk variant;Sample Size;Sampling;Self Management;Severity of illness;Signs and Symptoms;Site;skills;Standardization;study population;Susceptibility Gene;telehealth;Therapeutic;treatment optimization;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Racial Disparities in Parkinson Disease- Clinical Phenotype, Management and Genetics

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Next-generation sequencing studies have begun to unveil that RNA modifications are present in mRNAs, suggesting the intriguing potential of fine-tuning gene expression; however, identifying the precise location and occupancy has been a challenge. The low copy number of individual mRNA species, and difficulties in detecting RNA modifications in general, precludes the use of existing methods such as mass spectrometry and chemical labeling for transcriptome-wide identification. We propose to develop a nanopore/computational pipeline for discovery and quantification of the pseudouridine modification in order to facilitate the discovery of RNA modification sites important in disease and development.

PI_NAMEs: ROUHANIFARD, SARA HAKIM (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Address;Algorithms;Bar Codes;Base Pairing;Cell Line;cell type;Cells;Chemicals;computational pipelines;computerized tools;Consensus;Data;Data Set;Derivation procedure;Detection;Development;developmental disease;Disease;Enzymes;Foundations;Gene Expression;Generations;Gold;high standard;Human;Human Cell Line;immunogenicity;in vivo;Individual;Isomerism;Label;Ligation;Location;Machine Learning;Mammalian Cell;Maps;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;Modification;Molecular;Monitor;nanopore;next generation sequencing;novel;Outcome;Phenotype;Pseudouridine;recruit;Resistance;Ribonucleases;RNA;RNA-Binding Proteins;Role;Running;Sampling;Signal Transduction;single molecule;Site;Structure;success;Thermodynamics;Time;tool;Training;Transcript;transcriptome;transcriptome sequencing;Translations;Uridine;Work

PROJECT_TITLE: Synthetic mRNA Control Set for Nanopore-Based Pseudouridine Modification Profiling in Human Transcriptomes


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: PONCE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PUERTO RICO PONCE

ORG_STATE: PR

PHR: The didactic, research, mentoring, and career development activities proposed in this proposal will contribute to the successful training of the U-RISE UPRP student. These will increase the competitiveness of a diverse pool of underrepresented well-trained scientists. Trainees will develop technical, operational, and professional skills experiences, being aware of their ethical responsibility including rigor and reproducibility to transition and complete a higher degree (Ph.D, or M.D./Ph.D. in Biomedical areas.

PI_NAMEs: RUIZ-RIVERA, ABIGAIL  (contact);SUAREZ-MARTINEZ, EDU B

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affect;Assessment tool;Biology;Biomedical Research;career;Certification;college;Communities;Cultural Diversity;Curiosities;Development;disability;Doctor of Medicine;Doctor of Philosophy;Earthquakes;Economically Deprived Population;Education Projects;Educational process of instructing;emotional distress;Enrollment;Environment;Ethics;evidence base;experience;Fostering;Future;Generations;Graduation Rates;Hispanic Populations;Hurricane;innovation;Institution;interest;Learning;Mentors;next generation;pandemic disease;Participant;Population;programs;Puerto Rico;Qualifying;recruit;Research;responsible research conduct;Safety;Science;Scientist;Self Efficacy;skills;stressor;Students;System;Time;tool;Training;Underrepresented Students;Universities;Virtual Tool

PROJECT_TITLE: U-RISE AT UNIVERSITY OF PUERTO RICO AT PONCE

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Lung

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE Blood is designed to improve oxygen delivery and is essential for life yet, remarkably, stored blood has not been shown to improve tissue oxygenation and may actually worsen tissue perfusion. Close to 85 million units of red blood cells are administered worldwide each year so transfusion-related adverse events (including heart attack, organ injury, and death) are a major public health concern. An effective therapy to improve transfusion efficacy could have a major impact on the well-being of millions of patients.

PI_NAMEs: STAMLER, JONATHAN S. (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acceleration;Adverse event;adverse outcome;Anemia;Animal Model;Animals;Autologous;Automobile Driving;Binding;Blood;Blood Banks;Blood flow;Blood Transfusion;Blood Vessels;Bypass;Cardiovascular Physiology;Carrying Capacities;Cessation of life;Childhood;Clinical;Clinical Research;Clinical Trials;constriction;Control Animal;COVID-19 pandemic;Data;design;Devices;effective therapy;Erythrocytes;Event;Functional disorder;Gene Modified;Genetic;Goals;healthy volunteer;Heart failure;Heart Injuries;Hemoglobin;Hemoglobin concentration result;Homeostasis;Human;Hypoxia;Impairment;improved;improved outcome;in vivo;Inhalation;Injury to Kidney;insight;Ischemia;Life;Measures;Mediating;Mediator;Medical;Methods;Microcirculation;Molecular;Mus;Mutant Strains Mice;Mutate;Myocardial Infarction;Myocardial Ischemia;Nitric Oxide;novel;Observational Study;Operative Surgical Procedures;Organ;organ injury;Outcome;Oxygen;Pathology;Patient-Focused Outcomes;Patients;Perfusion;Peripheral;Personal Satisfaction;pharmacologic;Physiological;Positioning Attribute;Postoperative Period;pre-clinical;preclinical study;Procedures;prognostic;Protocols documentation;Public Health;public health relevance;Pulmonary Heart Disease;Pulmonary Hypertension;Regulation;research clinical testing;response;restoration;Role;S-Nitrosothiols;sensor;Site;Skeletal Muscle;SKIL gene;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;Time;tissue biomarkers;tissue oxygenation;Tissues;Transfusion;Vasodilation

PROJECT_TITLE: Restoration and Function of S-Nitrosothiol in Stored Blood

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Virtual screening is widely used to discover new chemical tools and leads for drug discovery. Unfortunately, the technique remains difficult to use, and has thus been restricted to a few expert laboratories. Here, we create databases and tools to bring virtual screening to a wide biological audience, much expanding its impact and usefulness, and develop a chemoinformatics method to identify the “on” and “off” targets for drugs and reagents.

PI_NAMEs: IRWIN, JOHN J. (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: 2019-nCoV;Address;Alloys;analog;Animals;Benchmarking;Biological;Biological Assay;Biology;Chemicals;Chemistry;Clinical Trials;Communities;Databases;Development;Docking;drug discovery;Drug Targeting;Excipients;Food;Food Additives;Goals;Hand;Informatics;informatics tool;inhibitor;interest;Knee;Laboratories;Letters;Libraries;Lysine;Mechanics;Methods;Online Systems;Peptide Hydrolases;Pharmaceutical Preparations;Pharmacology;physical property;programs;Quantum Mechanics;Reaction;Reagent;Research;Research Personnel;Science;side effect;small molecule;Statistical Mechanics;Structure;System;Techniques;Testing;Time;TMPRSS2 gene;tool;Trust;Vendor;virtual;virtual library;virtual screening;Work

PROJECT_TITLE: A Web-Based Automatic Virtual Screening System

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative  XX and XY sex chromosomes cause sex difference in disease, because of genes that protect or harm one sex more than the other. The current project develops new genetically modified rats in which the effects of sex chromosomes can be measured in animals that have the same type of gonad. The rats will be widely used in rat models of disease, to establish molecular mechanisms leading to sex differences in protection from disease.

PI_NAMEs: ARNOLD, ARTHUR P (contact);DWINELL, MELINDA R;GEURTS, ARON M

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;Adrenal Glands;Adult;Aging;Alzheimer's Disease;Animal Experimentation;Animals;Applications Grants;Autoimmune Diseases;autosome;Backcrossings;Behavioral;Biological Factors;Biomedical Research;Brain;brain morphology;Breeding;Cardiovascular Diseases;Cardiovascular Physiology;Categories;Cell Differentiation process;cell type;Cells;Chromosomes;Clustered Regularly Interspaced Short Palindromic Repeats;cognitive ability;cognitive function;Collaborations;Complex;Deposition;Development;Disease;disease model;DNA Sequence Alteration;dosage;Embryo;Estrous Cycle;Experimental Models;Fathers;Female;Fertility;Four Core Genotypes;Funding;Gene Expression;Gene Modified;Genes;Genetic;Genomics;gonad development;Gonadal Hormones;Gonadal structure;Growth;heart function;Histology;human disease;human model;Hypertension;Incidence;Kidney;Left;Literature;Lung Diseases;male;Malignant Neoplasms;Measures;Mission;Modeling;Modification;Molecular;mouse model;Mus;mutant;Mutation;Nature;Neurodegenerative Disorders;new therapeutic target;Obesity;offspring;Ovary;Pathway interactions;Physiology;Ploidies;Population;programs;protective factors;Puberty;Publishing;Pulmonary Hypertension;Rat Transgene;Rattus;Reproducibility;Reproduction;Reproductive Physiology;Research;Research Personnel;Resources;Sea;sex;sex as a biological variable;Sex Behavior;Sex Bias;Sex Chromosomes;Sex Differences;Sexual Development;sexual dimorphism;Site;Source;Specificity;Sprague-Dawley Rats;sry Genes;Stroke;System;Systemic hypertension;Testis;Tissues;tool;Transgenes;Transgenic Organisms;United States National Institutes of Health;Y Chromosome

PROJECT_TITLE: Transformative rat models to study sex differences in disease


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Rare Diseases

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Narrative This project will explore the physiological functions of aminoacyl-tRNA synthetase in the nucleus and their relationship to Charcot-Marie-Tooth (CMT) disease, the most commonly inherited neurological disorders affecting approximately 125,000 people in the United States.

PI_NAMEs: BURGESS, ROBERT W.;YANG, XIANG-LEI  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Alleles;Alzheimer's Disease;Amino Acids;Amino Acyl-tRNA Synthetases;Aminoacylation;Amyotrophic Lateral Sclerosis;autosome;Biological;biological adaptation to stress;Biological Models;Biological Process;Blood Vessels;Body Weight;Cell Nucleus;Charcot-Marie-Tooth Disease;Chromosomes;Curiosities;Data;Deformity;Development;Disease;Distal;Drosophila genus;Engineering;Enzymes;Equation;Eukaryotic Cell;gain of function;Gene Family;Genetic Transcription;Goals;HDAC1 gene;Hereditary Motor and Sensory Neuropathies;Heterozygote;Hindlimb;Homozygote;Huntington Disease;in vivo;in vivo Model;Inflammation;Inherited;Knock-in;Knowledge;Length;Limb structure;Link;Modeling;motor impairment;mouse model;multiple omics;Mus;Muscle;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;Neuropathy;novel;Nuclear;Nuclear Translocation;Oxidative Stress;Parkinson Disease;Pathway interactions;Patients;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;Phenotype;Physiological;Prevalence;Process;Protein Biosynthesis;Reaction;Reagent;Regulator Genes;Role;Sensory;skeletal;Specificity;System;Tissues;Transfer RNA;Transfer RNA Aminoacylation;United States;wasting;Weight maintenance regimen

PROJECT_TITLE: Exploring the Functions of tRNA Synthetases in the Nucleus and their Relationship to CMT

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Narrative We have discovered two unanticipated roles for telomeres, one in controlling nuclear envelope breakdown during meiosis, and another in providing a nuclear microdomain that promotes the reassembly of centromeres, which have a surprising tendency to become dismantled upon meiotic entry. In this proposal we define the molecular underpinnings and implications of these two noncanonical telomere functions.

PI_NAMEs: COOPER, JULIA PROMISEL (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Behavior;Binding;Biology;cancer cell;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Proliferation;Cells;Centromere;Centrosome;Chromatin;chromatin remodeling;Chromosomal Stability;chromosome missegregation;Chromosomes;cohesin;Complex;Conceptions;Cytoskeleton;endonuclease;Endowment;experimental study;Fission Yeast;Foundations;frontier;Generations;Genetic;Genome;Genome Stability;Genomic Instability;Human;In Vitro;in vivo;Interphase;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;Meiosis;Microscopy;Mitotic;Mitotic Cell Cycle;Molecular;Nuclear;nuclear division;Nuclear Envelope;Nucleosomes;optogenetics;Pathway interactions;Phase;Phosphotransferases;Plasmids;Process;Property;Prophase;Proteins;recruit;Research;Role;Series;SPO11 gene;stem;telomere;telomere loss;Textbooks;tool;transmission process;tumorigenesis;Work;Yeasts

PROJECT_TITLE: Defining the mechanisms and consequences of noncanonical telomere functions

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Babesia microti and Babesia duncani, the primary causative agents of human babesiosis in the United States, are naturally tolerant to current therapies and no vaccines are available to protect against these parasites. This proposal aims to characterize a unique set of secreted antigens exported by these parasites into the host, and to identify among them those that could be used to develop the first human babesiosis vaccines. The proposed research combines techniques in the fields of proteomics, cell biology and immunobiology; and its success will set the stage for future studies to evaluate the protective efficacy of these vaccines in humans.

PI_NAMEs: BEN MAMOUN, CHOUKRI  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Antibodies;Antigens;associated symptom;Babesia;Babesia microti;Babesiosis;Biological;Biology;Black-legged Tick;Blood;Blood Transfusion;Borrelia microti;California;Case Fatality Rates;Case Study;Cell membrane;Cells;Cellular biology;Clinical;Combined Modality Therapy;Cytoplasm;Dermacentor;detection assay;diagnostic assay;Disease;Dose;Environment;Erythrocyte Membrane;Erythrocytes;Future;Genomics;Goals;Human;Immune response;Immunization;Immunobiology;Immunocompetent;Immunodominant Antigens;immunogenicity;Immunoglobulin G;Immunoglobulin M;in silico;Incidence;Individual;Infection;Invaded;Kinetics;Life Cycle Stages;Link;Macrophage;Malaria;Measures;Membrane;Molecular;mouse model;Mus;Nanotrap;Oregon;Orthologous Gene;Parasites;Pathogenesis;Pathologic;Pharmaceutical Preparations;Plasmodium falciparum;Predisposition;protective efficacy;Protein Export Pathway;Protein Secretion;Proteins;Proteome;Proteomics;Recombinants;Recommendation;Reporting;Research;response;Serology;side effect;Spleen;success;Surface;System;Techniques;tick-borne;Ticks;transcriptomics;transmission process;United States;vaccine access;vaccine development;vaccine efficacy;vaccine trial;Vaccines;Virulence;Virulence Factors;Washington

PROJECT_TITLE: Antigen Discovery and Vaccine Development for Human Babesia Parasites


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE In 2014 there were an estimated 20,000 new cases of acute myeloid leukemia (AML) resulting in over 10,000 deaths. 20-25% of AML have very high expression of a gene called Meningioma-1 (MN1), and most of these patients have a very poor prognosis. We propose that MN1 causes leukemia by interfering with appropriate gene regulation, and that identifying critical mechanisms involved in this process may generate a path towards developing specific inhibitors that could help treat AML.

PI_NAMEs: BERNT, KATHRIN M (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;ATP phosphohydrolase;Behavior;Binding;Binding Sites;Bone Marrow;Bone Marrow Cells;Bromodomain;Catalytic Domain;Cell Line;Cessation of life;ChIP-seq;Chromatin;Complex;Consensus Sequence;CRISPR/Cas technology;Development;Diagnosis;drug development;Drug Targeting;Enhancers;Excision;Exposure to;gain of function;Gene Expression Regulation;Genes;Genetic Transcription;genome editing;Goals;Hematopoietic;Hematopoietic stem cells;Human;In Vitro;in vivo;Individual;inhibitor;insight;Kinetics;Knowledge;leukemia;leukemia treatment;leukemic transformation;leukemogenesis;loss of function;Malignant Neoplasms;Mediating;member;Meningioma by Site;Meningioma-1;Methods;Molecular;molecular imaging;Mus;mutant;Mutation;Myelogenous;Myeloid Progenitor Cells;novel;Nucleosomes;Oncogenic;overexpression;patient population;Patients;Play;Positioning Attribute;prevent;Process;progenitor;Prognosis;programs;promoter;recruit;Regulation;Reporting;Role;Sampling;single molecule;Site;Specificity;stem;System;targeted treatment;Transcription Coactivator;transcription factor;Variant

PROJECT_TITLE: A stalled chromatin regulatory network that mediates the oncogenic activity of Meningioma-1

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Autism;Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Machine learning (ML) is poised to enable faster and more accurate interpretation of medical images by augmenting the capabilities of experts. Success of ML techniques for medical image interpretation may reduce the burden on radiologists, reducing errors arising from fatigue or interruption, while simultaneously reducing costs and increasing speed and accuracy for patients. The cost and difficulty of generating expert quality labelled image data is the primary limitation preventing faster progress and deployment in more domains. We propose to address this problem by creating innovative algorithms that will construct reference quality labelled data with little input from domain experts, thus dramatically reducing the cost of labelling. These fundamental advances in informatics algorithms will reduce the cost and increase the rate of obtaining quality labels, which will in turn facilitate the widespread adoption and deployment of machine learning algorithms for image interpretation. Ultimately, this will stimulate the development of new imaging biomarkers that hold the potential to dramatically improve clinical decision-making and patient outcomes.

PI_NAMEs: WARFIELD, SIMON K (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Active Learning;Address;Adoption;Algorithms;Autism Diagnosis;autism spectrum disorder;Benchmarking;Brain;Characteristics;Child;Clinical;clinical decision-making;Collection;cost;Crowding;crowdsourcing;Data;Data Collection;Data Set;Databases;deep learning;design;Development;experimental study;Fatigue;Image;Image Analysis;imaging biomarker;imaging Segmentation;improved;Informatics;innovation;insight;Interruption;Label;Learning;learning algorithm;learning strategy;Life;Machine Learning;machine learning algorithm;Medical Imaging;Methods;Modeling;Morphologic artifacts;Noise;novel;novel strategies;Patient Care;Patient-Focused Outcomes;Patients;Performance;prevent;quantitative imaging;radiologist;Reference Standards;Research;Sampling;Speed;Structure;success;supervised learning;Techniques;Training;Uncertainty;Update

PROJECT_TITLE: Machine learning algorithms to analyze large medical image datasets

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Genetics;Human Genome

PHR: Project Narrative Fibroblasts in the synovial tissue lining compartment are pathologically expanded and implicated with tissue destruction in rheumatoid arthritis and osteoarthritis. Understanding the genetic pathways that drive these fibroblasts will lead to new targeted therapies for both diseases. This project will use cutting edge computational and experimental approaches to discovery and test potential drivers of synovial lining fibroblasts.

PI_NAMEs: KORSUNSKIY, ILYA  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Adopted;Advisory Committees;Algorithms;Arthritis;Atlases;Autoimmune;Benchmarking;Biological Assay;Biological Response Modifier Therapy;Biology;Biopsy;Blocking Antibodies;Cells;Cellular biology;Cluster Analysis;Computational Biology;cytokine;Data;Data Analyses;Data Set;Degenerative polyarthritis;Disease;efficacy testing;Equilibrium;Fibroblasts;Future;Genes;Genetic;genetic signature;Genomics;high dimensionality;Human;human tissue;Immunology;In Vitro;in vivo;Individual;Inflammation;Integrins;joint injury;Joints;Ligands;Maintenance;Measures;Mediating;Mentors;Meta-Analysis;Methods;Modeling;Molecular;Molecular Profiling;morphogens;multidisciplinary;Nature;new therapeutic target;NOTCH3 gene;novel;novel strategies;Paper;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;Phenotype;Population;Positioning Attribute;Principal Investigator;Process;Publishing;receptor;Recombinants;Reproducibility;Research;Rheumatoid Arthritis;Rheumatology;RNA;Role;Series;Signal Induction;Signal Transduction;single cell genomics;single-cell RNA sequencing;skills;Sorting;Statistical Data Interpretation;Synovial Membrane;Testing;Therapeutic;therapeutic target;Time;Tissues;Training;transcriptome sequencing

PROJECT_TITLE: Using high dimensional molecular data to decipher gene dynamics underlying pathogenic synovial fibroblasts

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Precision Medicine;Pulmonary Fibrosis;Racial and Ethnic Minority Health Research

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Pulmonary fibrosis (PF) is a destructive interstitial lung disease with no known cure and leads to death within 3-5 years in severe cases. Substantial heterogeneity in PF phenotypes limits the utility of current classification criteria in prognostication and treatment. This proposal is critical to improving PF classification and prognostic accuracy, by incorporating critical genomic factors from diverse races into a new classification scheme using cutting-edge statistical tools, thereby guiding personalized therapy in PF.

PI_NAMEs: ADEGUNSOYE, AYODEJI  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Address;Advisory Committees;Affect;African;American;Asian;Autoimmune;Big Data;biobank;Blood specimen;career;career development;Cessation of life;Characteristics;Chest;Chicago;Cicatrix;Classification;Classification Scheme;Clinical;Clinical Data;clinical decision-making;clinical implementation;clinical phenotype;clinical predictive model;Clinical Trials;Cluster Analysis;cohort;Cohort Studies;Collaborations;Data;Data Analyses;Dedications;Deterioration;Development Plans;Diagnosis;Diagnostic;Disease;disease classification;Disease Outcome;diverse data;DNA;Enrollment;Epidemiology;ethnic minority;European;Exclusion;Foundations;Frequencies;Future;Genetic;genetic association;Genetic study;genetic variant;genomic biomarker;genomic data;genomic predictors;Genomics;Genotype;Goals;Health Sciences;Heterogeneity;Hispanic;Hospitals;idiopathic pulmonary fibrosis;improved;Institution;Interstitial Lung Diseases;Investigation;Journals;K-Series Research Career Programs;Length;Leukocytes;Master of Science;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Minority;Modeling;MUC5B gene;multidisciplinary;Outcome;outcome prediction;patient oriented research;patient registry;Patient-Focused Outcomes;Patients;peripheral blood;personalized medicine;Pharmacogenomics;Pharmacotherapy;Phenotype;phenotypic data;Physicians;Population;Population Heterogeneity;precision medicine;predictive modeling;predictive tools;Prevalence;Prognosis;prognostic;prognostication;prospective;Public Health;Publishing;Pulmonary Fibrosis;pulmonary function;Quality of life;Race;racial difference;racial diversity;racial minority;racial population;Registries;Research;Resources;respiratory;risk stratification;Sampling;Scientist;Single Nucleotide Polymorphism;skill acquisition;skills;Societies;Solid;stem;Subgroup;success;survival prediction;telomere;Testing;Time;TOLLIP gene;tool;Training;Translations;treatment effect;Treatment outcome;treatment response;Universities;Validation;Variant;Work

PROJECT_TITLE: Improving Pulmonary Fibrosis Classification with Genomics Informed Phenotypic Clusters


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The NHGRI Centers for Mendelian Genomics (CMGs) have contributed substantial knowledge to the genetic basis of thousands of Mendelian diseases over the past decade, but diagnostic rates across the full set of conditions remain low. The NHGRI Mendelian Genomics Research Consortium will build on the CMGs' success by applying technological and data-sharing innovations to accelerate the further discovery and genetic characterization of Mendelian conditions. As the Data Coordinating Center for the Consortium, we will lead efforts to establish Consortium-wide data standards, utilize cloud-based resources to enable rapid data sharing among Consortium members and timely release to the broader scientific community, manage the opportunity fund supporting scalable functional studies of candidate genes and variants, and coordinate program logistics and outreach.

PI_NAMEs: MAY, SUSANNE  (contact);SHOJAIE, ALI

PROGRAM_OFFICER_NAME: WELLINGTON, CHRISTOPHER

PROJECT_TERMS: Acceleration;Adherence;Authorship;Award;Bioethics;Biological;Biometry;Candidate Disease Gene;causal variant;ClinVar;cloud based;cohort;Collaborations;Communication;Communities;Complex;Data;Data Coordinating Center;Data Science;data sharing;data standards;data submission;Deposition;Diagnosis;Diagnostic;Disease;Education;Ensure;exome sequencing;experience;experimental study;FAIR principles;Family;follow-up;Funding;Funding Opportunities;Genes;Genetic;Genetic Research;Genome;genome sequencing;genomic data;Genomics;Group Meetings;Health Benefit;Human Genetics;Incentives;innovation;insight;International;Knowledge;Lead;Logistics;Medical Genetics;meetings;member;Mendelian disorder;Mentorship;Methodology;Molecular;National Human Genome Research Institute;novel;outreach;outreach program;Persons;Phenotype;phenotypic data;Play;Policies;Procedures;Process;programs;Public Health;Quality Control;rare variant;Reporting;repository;Research;Research Personnel;Resources;Rest;success;Surveys;Syndrome;System;Technology;Training;United States National Institutes of Health;Universities;Untranslated RNA;Validation;Variant;virtual;Washington;web site;whole genome;Work;working group

PROJECT_TITLE: University of Washington (UW) Mendelian Genomics Data Coordinating Center


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: GAINESVILLE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: COTTLER, LINDA B.;NIXON, SARA JO (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;Florida;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;Universities;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 18/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT THE UNIVERSITY OF FLORIDA


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Human Genome;Neurosciences

ORG_CITY: CHICAGO

PHR: Narrative. Despite the plethora of ways that developmental experience influences long-term patterns of behavior, our mechanistic understanding of how this occurs is limited. Here, we apply state-of-the-art sequencing technologies to identify the epigenetic and molecular signatures of select cells recruited for developmental learning in juveniles. The proposed research thus begins to fill a void in developmental neurobiology by applying an unprecedented level of detail to the structural organization of functional networks.

PI_NAMEs: LONDON, SARAH E (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adolescent;Adult;Age;Animal Model;Area;Auditory;Behavior;Behavioral;Birds;Brain;brain cell;Brain region;brain tract;cell type;Cells;Chromatin;Chromatin Structure;Data;Data Set;Development;developmental neurobiology;Epigenetic Process;experience;Explosion;Female;Foundations;Genomics;Goals;hatching;Immunohistochemistry;Individual;innovation;insight;Investigation;Learning;male;Memory;Methods;Molecular;Molecular Biology;molecular marker;Molecular Profiling;multiple omics;neural network;Neuronal Plasticity;novel;Outcome;Pattern;Phase;Phosphorylation;Population;Process;Productivity;programs;Property;Prosencephalon;Publishing;recruit;remediation;Research;Research Personnel;response;Ribosomal Protein S6;RNA;sex;Shapes;single cell ATAC-seq;single cell sequencing;Songbirds;spatial integration;System;Techniques;Technology;Testing;Time;trait;transcriptome sequencing;transcriptomics;women versus men;zebra finch

PROJECT_TITLE: At the right time and place – identifying epigenetic and molecular determinants of a developmental learning window

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: LA JOLLA

PHR: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the etiological agent responsible for COVID19 disease in the current pandemic. RNA recombination is required during normal replication to generate subgenomic mRNAs required for protein expression, gives rise defective viral RNAs and generates numerous structural variants that facilitate adaption and evolution of SARS-CoV-2. We will characterize the molecular mechanisms that determine the sites and rates of RNA recombination and learn how selection in different physiological environments results in the selection and emergence of novel variants of SARS-CoV-2.

PI_NAMEs: ROUTH, ANDREW LAURENCE (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Air;Anti-viral Therapy;Automobile Driving;Cell Culture Techniques;Cell Differentiation process;cell type;Cells;Chronic;clinical research site;Coronavirus;COVID-19;COVID-19 patient;current pandemic;Databases;Disease;Disease Outcome;emerging virus;endonuclease;Environment;Epidemic;Etiology;Event;Evolution;fitness;future outbreak;Generations;Genetic Recombination;Human;IFNAR1 gene;Immune;Immune Evasion;Immune response;Immunocompromised Host;improved;Infection;Innate Immune Response;insertion/deletion mutation;Learning;Life Cycle Stages;Liquid substance;Livestock;Lung;Measures;Messenger RNA;microdeletion;Microscopy;Middle East Respiratory Syndrome;Minority;Modeling;Molecular;mouse model;Mus;Mutate;Mutation;Nature;novel;novel coronavirus;Open Reading Frames;pandemic disease;pathogenic virus;Patients;Phylogenetic Analysis;Physiological;Play;Polymerase;prevent;Property;protein expression;Proteins;receptor binding;recombinant RNA;Replication Initiation;Reporter Genes;Reproducibility;reverse genetics;RNA;RNA Viruses;RNA-Directed RNA Polymerase;Role;Sampling;SARS-CoV-2 infection;SARS-CoV-2 positive;SARS-CoV-2 spike protein;SARS-CoV-2 variant;Serial Passage;Site;Source;System;Testing;Time;Tissues;transmission process;trend;vaccine failure;Variant;variants of concern;Viral;viral fitness;Viral Genome;Viral Pathogenesis;viral RNA;Virulence

PROJECT_TITLE: RNA Recombination in Coronaviruses

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Headaches;Mental Health;Mental Illness;Migraine;Neurosciences;Pain Research;Psychosis

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Olfactory hallucinations can be symptomatic of various psychiatric or neurological disorders, including schizophrenia, Parkinson’s disease, epilepsy, and migraines. This project will determine olfactory-based behavioral and neural changes induced by hallucinogens in mice. These studies will further our understanding of sensory processing during perceptual disturbances, a necessary component for the advancement of diagnosis and treatment of several disorders.

PI_NAMEs: WELCH, AMANDA COLETTE (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Affect;Animal Model;Animals;Area;Behavior;Behavioral;Biological Models;Computer Analysis;Data;Diagnosis;Disease;Environment;Epilepsy;Ethology;Event;experience;Eye Movements;Goals;Hallucinations;Hallucinogens;Head;Head Movements;Human;Implant;insight;Machine Learning;Measures;Mediating;Mental disorders;Methods;Migraine;Molecular;Movement;multi-electrode arrays;Mus;Nervous System Disorder;neural;neural circuit;neuromechanism;Neurons;neurophysiology;Odors;olfactory bulb;Olfactory Cortex;Olfactory Hallucinations;Olfactory Pathways;Parkinson Disease;Perception;Perceptual disturbance;Pharmaceutical Preparations;Policies;Psilocybin;receptor;receptor expression;Reporting;Research;Resolution;response;Saline;Sampling;Schizophrenia;Sensory;Serotonergic System;Smell Perception;Source;Stimulus;Structure;System;Testing;tool;Training;verbal;Visual Hallucination;Work

PROJECT_TITLE: The impact of hallucinogens on active sampling and the olfactory bulb