ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: POTOMAC

ORG_NAME: MIRA MEDICAL, LLC

PHR: Project Narrative We propose the development of a machine learning framework named the Forearm Fracture AI-driven Recommendation System (FFAIRS) to improve forearm fracture management in pediatrics. Our primary goal is to leverage machine learning to generate recommendations for treating forearm fractures based on clinical presentation and x-ray analysis.

PI_NAMEs: CLEARY, KEVIN R. (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Address;Adult;Ambulatory Care Facilities;Anatomy;Area;Benchmarking;bone;Caring;Child;Child health care;Childhood;Client satisfaction;Clinical;Clinical Research;Collaborations;commercialization;Computer software;Confidence Intervals;Consult;Consultations;cost;Data;data anonymization;demographics;Development;diagnostic strategy;Distal;Effectiveness;Epiphysial cartilage;Evaluation;Family;feasibility testing;Feedback;Forearm;Forearm Fracture;Fracture;functional restoration;Future;Goals;Health Care Costs;Health Insurance Portability and Accountability Act;Healthcare;healthcare burden;Hospitals;Immobilization;improved;Incidence;Injury;Inpatients;Lead;learning strategy;Length;long bone;Machine Learning;machine learning framework;machine learning model;Marketing;Medical center;Modeling;musculoskeletal injury;Names;optimal treatments;Orthopedic Surgery;Orthopedics;Outcome;Parents;Pathway interactions;Patient-Focused Outcomes;Patients;pediatric emergency;Pediatric Hospitals;Pediatric Surgical Procedures;Pediatrics;Performance;Persistent pain;Phase;Physical Examination;prevent;radiological imaging;Recommendation;Reporting;Resource Allocation;Resources;Retrospective Studies;ROC Curve;Roentgen Rays;self supervised learning;Small Business Technology Transfer Research;Specialist;Specialized Center;Splint Device;Surgeon;surgical service;System;tertiary care;Testing;Training;training data;urgent care;usability;user-friendly;Wait Time;wasting;web app;Work

PROJECT_TITLE: AI Enabled App for Fracture Reduction Prediction in Pediatrics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: Brooklyn

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LUCERNA, INC.

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT There are currently no effective vaccines or antiviral drugs for most of the viral diseases afflicting human. Targeted RNA degradation is a new therapeutic approach with the potential to make more small molecules drugs viable and resistance-proof. This project will develop a cell-based assay platform that monitors viral RNA turnover more accurately to accelerate the discovery of targeted RNA degradation-based antiviral therapies.

PI_NAMEs: O'HANLON, RYAN  (contact)

PROGRAM_OFFICER_NAME: DAVIS, MINDY I

PROJECT_TERMS: 2019-nCoV;Acceleration;Affect;Affinity;analytical method;Anti-viral Agents;Anti-viral Therapy;Binding;Biogenesis;Biological Assay;C9ORF72;Cells;Chimera organism;Code;Communities;Consumption;Coupling;Cytosol;Data;Dengue;Dengue Virus;design;Development;Disease;drug discovery;drug efficacy;Drug resistance;Drug Targeting;drug use screening;Elements;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genomics;high throughput screening;Housekeeping;Human;Human Genome;improved;Influenza;influenzavirus;Life Cycle Stages;Ligands;Luciferases;Measures;Messenger RNA;MicroRNAs;Monitor;mRNA Export;Nature;Noise;novel therapeutic intervention;novel therapeutics;Nucleic Acids;Oligonucleotides;Oncogenic;Pancreatic ribonuclease;pathogen;Performance;Pharmaceutical Preparations;Phase;phase 2 study;Phenotype;Play;Predisposition;protein degradation;Protein Engineering;Proteins;Proteome;public health relevance;Publishing;Recording of previous events;recruit;Reporter;Reporting;Resistance;Resistance development;resistance mutation;Resistance profile;response;Ribonucleases;RNA;RNA Degradation;RNA Viruses;scaffold;screening;Signal Transduction;Signaling Protein;Site;Small Business Innovation Research Grant;small molecule;small molecule therapeutics;Specificity;structural biology;Structure;System;Technology;therapeutic target;Time;Transcript;Translations;Untranslated RNA;Vaccines;Validation;Viral;viral resistance;viral RNA;virtual;Virus Diseases

PROJECT_TITLE: Targeted RNA degradation assay for new antiviral drug discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-G (15)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Biotechnology;Cancer;Neurosciences;Prostate Cancer;Urologic Diseases

ORG_CITY: WOODSIDE

ORG_NAME: MANZANITA PHARMACEUTICALS, INC.

ORG_STATE: CA

PHR: NARRATIVE Translational safety studies in novel nerve imaging agent for radical prostatectomies In this proposal, we will complete IND-enabling (safety) studies of NerveLight, a novel nerve imaging agent applied locally and topically, to bathe the prostate at the beginning of surgery. There is no commercial product. NerveLight is a conjugate, comprised of a commercially available, small molecule Near InfraRed fluorescent dye attached directly (no linker) to recombinant human Nerve Growth Factor (rhNGF) that binds to the nerve endings of sensory nerves, then is transported (“what the surgeon sees” is retrograde axonal transport of the fluorescent dye) – up the nerves. The FDA requires that we test the conjugate, but the components have been shown to be clinically safe.

PI_NAMEs: KAHL, STEPHEN B (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: absorption;Acute;adduct;Adult;afferent nerve;Affinity;Anesthesia procedures;Antibodies;Axonal Transport;Back;Bathing;Binding;Biochemical;Biochemistry;Bladder;Canis familiaris;Cells;Chemistry;Clinical;clinical development;clinical imaging;Clinical Pathways;commercialization;Complex;cost;Data;design;Development;Distal;Dose;Dyes;efficacy study;Euthanasia;Excision;Exposure to;Eyedrops;falls;Fluorescent Dyes;Funding;Hematology;Histology;Human;Image;imaging agent;imaging system;Impotence;In Vitro;in vivo;Incontinence;Indocyanine Green;Injections;interstitial;Intravenous;Irrigation;male;Malignant neoplasm of prostate;manufacture;Maps;Marketing;Measures;Memory;men;Methods;Molecular;near infrared dye;Nerve;Nerve Endings;Nerve Growth Factors;Nerve Tissue;neuro-oncology;Neurologic;Neurology;neuronal cell body;Neurons;neurovascular;No-Observed-Adverse-Effect Level;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Palpation;Periprostatic;Pharmacology;Pharmacology Study;Phase;phase 1 study;Procedures;Prostate;Protocols documentation;Publishing;Radical Prostatectomy;Rattus;receptor;Recombinants;Recurrence;Regulatory Affairs;Regulatory Pathway;retrograde transport;Risk;Route;Safety;safety study;Science;Sensory Nerve Endings;side effect;Site;Small Business Innovation Research Grant;small molecule;spared nerve;standard of care;success;Surgeon;Surgical incisions;Surgical Oncology;Surgical sutures;System;Testing;Time;Tissue Harvesting;Tissues;tool;Toxic effect;Toxicology;tropomyosin kinase;Urologic Cancer;Variant;Visualization

PROJECT_TITLE: Toxicology (IND-enabling) studies for a novel nerve imaging agent for prostate cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Regenerative Medicine;Wound Healing and Care

ORG_CITY: PALO ALTO

ORG_NAME: ADEPTHERA, LLC

PHR: Based on human hormones essential for maintaining normal vasculogenesis and vascular integrity, we have developed self-assemble peptide analog gels to reduce ischemic tissue damage and improve local blood supply to traumatic wound areas. To facilitate the development of analog gel therapy, we propose to identify an optimal gel lead and demonstrate its efficacy in two pressure ulcer models. Successful development of this therapy could significantly reduce morbidity and mortality resulting from chronic wounds in pressure ulcer patients.

PI_NAMEs: HSU, SHEAU-YU TEDDY (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Acceleration;Address;adrenomedullin;Aging;Agonist;analog;angiogenesis;Animals;Area;Blood Circulation;Blood flow;Blood Vessels;Calcitonin Gene-Related Peptide;Cellulitis;Cessation of life;Chronic;chronic wound;Circulation;Data;db/db mouse;decubitus ulcer;Dermal;Development;diabetic;Diabetic mouse;Disease;Dose;drug candidate;Drug Kinetics;efficacy evaluation;Elderly;endothelial dysfunction;Evaluation;Family;FDA approved;Formulation;Future;Gel;Goals;Growth Factor;healing;hemodynamics;Hindlimb;Hormones;Human;improved;In Situ;Incidence;Infection;Inflammatory;Injury;Invaded;Ischemia;ischemic injury;Lead;lead optimization;Liquid substance;Metabolic Diseases;microorganism;mimetics;Modality;Modeling;monomer;Morbidity - disease rate;mortality;Mus;NanoGel;open wound;Pathology;Pathway interactions;Patients;peptide analog;Peptides;Persons;pharmacokinetics and pharmacodynamics;Pharmacology Study;phase 1 study;Platelet-Derived Growth Factor;Play;Population;pressure;process optimization;Rattus;receptor;regenerative;regenerative therapy;Reporting;Role;Safety;self assembly;Sepsis;Series;Signal Transduction;skin ulcer;stem cells;Stress;subcutaneous;Therapeutic;therapy development;tissue regeneration;Tissues;Toxicology;Translating;traumatic wound;vascular bed;Vascular blood supply;vasculogenesis;Work;wound;wound care;wound closure;wound healing

PROJECT_TITLE: Regenerative peptide therapy to accelerate pressure ulcer healing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: LAKE FOREST

ORG_NAME: ALLVIVO VASCULAR, INC.

PHR: PROJECT NARRATIVE Patients that require hemodialysis are at increased risk for blood stream infections, largely due to long term dependance on vascular access and a high prevalence of central venous catheter (CVC) use. The results of this work will improve safety and reduce the cost of delivering hemodialysis to patients with end stage renal disease by preventing catheter related infections. This will be accomplished by developing a simple to use catheter end cap that functions as an antimicrobial barrier and delivery device to kill infection-causing microorganisms inside hemodialysis catheter hubs.

PI_NAMEs: NEFF, JENNIFER ANN (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Achievement;anti-microbial peptide;Antibiotics;antimicrobial;Bacteria;Biocide;Blood;Blood Vessels;care costs;catheter related infection;Catheters;Cessation of life;cost;Cost Control;Data;design;Development;Devices;Dialysis procedure;Discipline of Nursing;Distal;Dose;efficacy evaluation;End stage renal failure;Engineering;Evaluation;Event;Excision;Exposure to;Formulation;Foundations;Funding;Gatekeeping;Goals;Government;Gram-Negative Bacteria;Gram-Positive Bacteria;Hemodialysis;High Prevalence;Hospitalization;Hospitals;Hour;improved;Infection;Infection Control;infection risk;Insurance Carriers;invention;Ions;Lead;Length of Stay;manufacture;Marketing;Measures;Metals;Microbe;microbial;Microbial Biofilms;microbial colonization;microorganism;migration;Modeling;Morbidity - disease rate;mortality;Multiple Bacterial Drug Resistance;novel;Nurses;particle;Particulate;pathogen;Patients;Peptides;Performance;Peripheral;Persons;Phase;Positioning Attribute;Preclinical Testing;preservation;prevent;Procedures;Process;Production;prototype;Quality of Care;recurrent infection;Research;Risk;Risk Reduction;Safety;Sampling;Site;Small Business Innovation Research Grant;Sterilization;Stream;success;Surface;Technology;Temperature;Time;Veins;Venous;Work;Yeasts

PROJECT_TITLE: Catheter Cap with Anti-biofilm Luminal Insert

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Social Determinants of Health;Urologic Diseases

ORG_CITY: NORTHAMPTON

ORG_NAME: LATDE DIAGNOSTICS CORP.

ORG_STATE: MA

PHR: Project Narrative Urinary tract infections (UTIs) impact ~13 million patients and account for up to 6% of healthcare visits and over 1 million emergency department visits in the U.S. each year, with significantly higher risk in women and low- income communities. Shortening the time it takes to identify the most effective therapy for UTI from the current 3 days to 90 minutes can improve patient outcomes, save billions in healthcare costs and help preserve life- saving antibiotics. Latde Diagnostics is developing a rapid, equitable antibiotic susceptibility test that can guide treatment decisions and can be readily integrated into resource-limited and outpatient clinical settings.

PI_NAMEs: MELZER, EMILY S (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Adoption;Adverse effects;aggressive therapy;Amino Acids;analog;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;Antibodies;antibody detection;antimicrobial;Antimicrobial Resistance;assay development;Automobile Driving;Bacteria;Binding;Biocompatible Materials;Biological Assay;Businesses;Cell Membrane Permeability;Cell surface;Cell Wall;Centrifugation;Clinical;clinically relevant;commercialization;Communicable Diseases;Communities;cost;Coupled;Couples;design;Detection;detection assay;detection method;Deterioration;Diagnosis;Diagnostic;Diagnostic Reagent Kits;diagnostic tool;Disparity;Disproportionately impacts women;effective therapy;Emergency department visit;Equipment;Equity;Escherichia coli;Fatality rate;Food;Future;Gender;Genetic;Goals;Growth;Guidelines;Health;Health Care Costs;Health Care Visit;health inequalities;Health Personnel;high risk;Hour;Immobilization;improved;Incidence;Incubated;Individual;individualized medicine;Industry;infection management;Innovation Corps;instrument;instrumentation;Interview;Label;Laboratories;Lateral;lateral flow assay;Life;Link;Liquid substance;low and middle-income countries;Low income;Marketing;medical complication;Metabolic;Methods;microbial;Outcome;Outpatients;overtreatment;Pain;pathogen;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Phenotype;Predisposition;Preparation;preservation;pressure;prevent;Production;prototype;Provider;rapid detection;rapid test;research clinical testing;Resistance;resistant strain;Resource-limited setting;Resources;Risk;risk minimization;sample collection;Sampling;side effect;Socioeconomic Status;socioeconomics;Specificity;Sterility;Structure;Surface;Symptoms;Technology;technology platform;Testing;Time;tool;Urinary tract infection;Woman

PROJECT_TITLE: Rapid, equitable, lateral flow-based antibiotic susceptibility testing for urinary tract infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-R (11)]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Relevance: The brain shows marked plasticity across a variety of learning and memory tasks as well as during recovery after injury. This proposal aims to investigate targeted stimulation of cortex to drive cortical plasticity and induce functional recovery via state-of-the-art electrophysiology and optogenetics to simultaneously record and manipulate activity of sensorimotor neurons in awake behaving macaques. Understanding the role of these basic physiological phenomena will shed light on underlying mechanisms of brain plasticity that leads to functional reorganization in the brain and can provide us with vital insight to develop stimulation-based therapies for a broad range of neurological disorders such as stroke.

PI_NAMEs: YAZDAN SHAHMORAD, AZADEH  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Area;awake;behavior measurement;Behavioral;Brain;brain machine interface;cell type;density;design;Disease;Effectiveness;Electrophysiology (science);Engineering;experimental study;Foundations;Future;Goals;Human;injured;Injury;injury recovery;insight;Ion Channel;Ischemia;ischemic lesion;Learning;Lesion;Light;Location;Macaca;Maps;Measures;Memory;Morphologic artifacts;Motor Cortex;Nervous System Disorder;neural;neural patterning;neurological rehabilitation;Neuronal Plasticity;Neurons;neuroregulation;Neurosciences;novel;novel strategies;optogenetics;Pattern;Physiologic pulse;Physiological;Recovery of Function;Rehabilitation therapy;Reporting;Research;Role;sensorimotor system;Solid;Somatosensory Cortex;Specificity;Stroke;System;Techniques;Testing;Therapeutic Intervention;Time;tool;Transfection;Viral

PROJECT_TITLE: Engineering neuroplasticity using volitional control of activity-dependent optogenetic stimulation in macaque sensorimotor cortex

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: VA developed the Life Sustaining Treatment Decisions Initiative (LSTDI) to elicit, document, and honor the values, goals, and preferences of Veterans with serious illness. The LSTDI is important to Veterans because it ensures they can express their preferences for life sustaining treatments (e.g., cardiopulmonary resuscitation, breathing machine, artificial nutrition) and have them honored. However, across VA nationally, only 39% of LSTDI conversations occur in the outpatient setting; the majority occur in the inpatient setting often close to death. At this late stage, Veterans are often not able to make their preferences known because they are so ill. Decisions fall to surrogates who may be uncertain about what the Veteran would have wanted. This study will examine ways to increase LSTDI conversations among Veterans and their health care providers earlier in illness in the outpatient setting.

PI_NAMEs: BEKELMAN, DAVID B. (contact);WALLING, ANNE M

PROJECT_TERMS: Academy;Address;Breathing;Cardiopulmonary Resuscitation;Caregivers;Caring;Cessation of life;Characteristics;Chronic Disease;Chronic Obstructive Pulmonary Disease;Collaborations;Colorado;COVID-19;COVID-19 morbidity;COVID-19 mortality;Data;data warehouse;decision-making capacity;Dementia;Documentation;effectiveness evaluation;end of life care;Ensure;Ethics;Evaluation;evidence base;experience;Failure;falls;Family;Fostering;Foundations;Goals;Health;Health Personnel;Health system;Healthcare;Healthcare Systems;Heart failure;high risk;Hospitalization;implementation strategy;improved;innovation;Inpatients;interest;Interview;Kidney Diseases;Learning;Life;Liver diseases;Los Angeles;Lung Diseases;Malignant Neoplasms;Mechanical ventilation;Medical;Medical center;Medicine;meetings;member;Methodology;Methods;Needs Assessment;nutrition;operation;Outpatients;Palliative Care;Participant;Patients;Personal Satisfaction;Persons;Policies;population based;preference;Primary Care;prognostic;Provider;Randomized;Recommendation;Research;research and development;Research Design;Resources;Resuscitation;Risk;Sequential Multiple Assignment Randomized Trial;Site;success;Surveys;telehealth;Testing;Time;Training;Veterans;Visit;web site

PROJECT_TITLE: Improving Implementation of Outpatient Goals of Care Conversations for Veteranswith Serious Illness

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Heart Disease;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE  The pericardium is the mesothelial sac that surrounds the heart and is essential to support its development, maintain cardiac homeostasis over time, and respond to cardiac injury and infection. However, the developmental origins of pericardial development, and the cellular and molecular mechanisms involved in determining cell fate decisions between the pericardium and other parts of the cardiovascular system remain unknown. This will be the focus of my investigations, and the results from this work will expand our understanding of cardiogenesis and provide a framework to study the homeostatic functions of the pericardium.

PI_NAMEs: MORAN, HANNAH ROSE (contact)

PROGRAM_OFFICER_NAME: LIDMAN, KARIN FREDRIKSSON

PROJECT_TERMS: AXIN2 gene;beta catenin;Binding;Binding Sites;Biology;Body System;Cardiac;cardiogenesis;Cardiovascular system;Cell Lineage;cell type;Cells;Color;Complex;congenital anomaly;congenital heart abnormality;CRISPR/Cas technology;Data;Development;Embryo;Embryonic Development;Encapsulated;Epicardium;Feedback;Friction;Gene Proteins;Genes;Genetic;Genetic Markers;Genetic Transcription;genomic locus;Goals;Heart;Heart Injuries;Homeostasis;Human;Image;in vivo;Infection;inhibitor;Injury;insight;Investigation;knock-down;Label;Lateral;Link;Maps;Mesoderm;Mesothelial Cell;Mesothelium;Microscopy;migration;Mining;Molecular;Morphogenesis;Mutagenesis;mutant;Mutate;Natural regeneration;Nucleic Acid Regulatory Sequences;overexpression;Parietal;Pathway interactions;Pattern;Pericardial body location;pericardial sac;Phenotype;predictive modeling;Process;progenitor;Property;Regulation;Regulatory Element;Reporter;Research;Research Proposals;Role;Signal Transduction;single-cell RNA sequencing;Source;spatiotemporal;stem cell population;Structure;Testing;Time;Tissues;tool;transcription factor;Transgenic Organisms;Tube;Visceral;Visualization;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Defining the developmental mechanisms of pericardium formation


PHR: Previous studies suggest that Veterans with a below the knee amputation using passive-elastic or powered prostheses have impaired physical function, which could increase the risk of osteoarthritis, leg/back pain, and diabetes/obesity. Use of an advanced prosthesis that has optimal stiffness and power output could thus restore function, which would increase physical activity and reduce risk. We will systematically determine the independent and combined effects of using a passive-elastic prosthesis with different stiffness categories beneath a battery-powered ankle-foot prosthesis with different magnitudes of prosthetic power output on the metabolic cost (effort), biomechanics (movements and forces), muscle activity, and satisfaction for Veterans with below the knee amputations during walking at a range of speeds. Such evidence-based measures would enhance prosthetic technology, which could reduce comorbidities, while improving quality of life, comfort, and physical function, and advancing rehabilitation research and development for Veterans with leg amputations.

PI_NAMEs: GRABOWSKI, ALENA  (contact)

PROJECT_TERMS: Affect;Amputation;Ankle;ankle prosthesis;Back Pain;Biological;Biomechanics;Categories;comorbidity;Computer software;cost;Degenerative polyarthritis;Diabetes Mellitus;Elasticity;evidence base;Felis catus;foot;Functional impairment;functional improvement;functional restoration;Germany;Goals;Health;Health Care Costs;improved;in vivo;Individual;Joints;kinematics;Kinetics;Knee;Lead;Leg;Limb Prosthesis;Lower Extremity;Manufacturer;Materials Testing;Measures;mechanical energy;Mechanics;Metabolic;Movement;Muscle;Obesity;Osteoporosis;Output;Pain in lower limb;pain reduction;Participant;Persons;Phase;Physical activity;Physical Function;physical impairment;powered prosthesis;Property;Prosthesis;prosthesis control;Prosthesis Design;prosthetic foot;Quality of life;Questionnaires;Recommendation;Recovery;rehabilitation research;Rehabilitation therapy;research and development;Resources;Risk;Risk Reduction;satisfaction;Series;Services;Shapes;Shoes;Speed;Technology;Testing;Time;Torque;treadmill;Veterans;Walking;walking speed;Work

PROJECT_TITLE: How Do Lower Limb Prosthetic Stiffness and Power Affect the Biomechanics, Metabolic Costs, and Satisfaction of Veterans with Transtibial Amputations DuringWalking?

STUDY_SECTION_NAME: Rehabilitation Engineering & Prosthetics/Orthotics [RRD5]


ORG_CITY: BOSTON

ORG_NAME: VA BOSTON HEALTH CARE SYSTEM

PHR: Proactive goals of care conversations (GoCCs) are a hallmark of high-quality, patient-centered care, allowing healthcare providers to tailor end-of-life care to patient values. When done well, GoCCs improve outcomes for patients, family/caregivers, providers, and healthcare systems. Unfortunately, proactive GoCCs remain vastly underutilized. The emergence of the COVID-19 pandemic in March 2020 and its disruption to healthcare emphasized the need for explicit GoCCs to elicit patient goals and preferences. This study will assess how the pandemic disrupted implementation of VA’s Life-Sustaining Treatment Decisions Initiative (LSTDI), a standardized approach to conducting and documenting GoCCs. We will evaluate how COVID affected rates of GoCCs during [and after] the pandemic and catalyzed innovations to the LSTDI. We will identify [sustainable] best practices to improve frequency, quality, and equity of outpatient GoCCs that remain relevant post- pandemic and create a highly usable playbook to improve LSTDI implementation at low-performing VA sites.

PI_NAMEs: LINSKY, AMY  (contact);WIENER, RENDA SOYLEMEZ

PROJECT_TERMS: Advance Care Planning;Affect;Attention;Black race;Caregivers;Caring;catalyst;Cessation of life;Characteristics;Clinical;clinical risk;COVID-19;COVID-19 impact;COVID-19 pandemic;Dementia;design;Deterioration;Development;Disparity;Documentation;Effectiveness;end of life care;Ensure;Equity;Ethics;Evaluation;experience;Family;Frequencies;Goals;Guidelines;hazard;health care delivery;Health Personnel;Healthcare;Healthcare Systems;high risk;implementation framework;implementation science;implementation strategy;improved;improved outcome;innovation;Interruption;Interview;Learning;Length;Life;long term COVID-19 pandemic impacts;long-standing disparities;Measures;Methods;Modality;novel;Outcome;Outpatients;outreach;pandemic disease;pandemic disruption;patient oriented;Patient-Centered Care;Patient-Focused Outcomes;Patients;post-pandemic;pre-pandemic;preference;Primary Care;Process;Provider;provider adoption;Quality of Life Assessment;Racial Equity;response;Series;shared decision making;Site;Specific qualifier value;Standardization;Structure;surrogate decision maker;telehealth;Time;Time Series Analysis;Training;uptake;usability;Variant;Veterans;Work

PROJECT_TITLE: Impact of COVID-19 on implementation and outcomes of VA's Life-Sustaining TreatmentDecisions Initiative


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Neurosciences;Sleep Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Sleep disorders, such as insomnia, affect a substantial portion of the population and are twice as likely to occur in women as compared to men. Little is known about how sex hormones such as estradiol mechanistically affect sleep-wake cycles in women, though women tend to report more sleep disturbances during times of hormonal fluctuations. Gaining a better understanding of how estradiol affects sleep will ultimately help us be able to develop targeted treatments for women who report sleep disturbances.

PI_NAMEs: KRUK, KATIE  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Adenosine;ADORA2A gene;Adult;Affect;Agonist;Animals;Attenuated;Brain;Brain Stem;Cell Nucleus;Cells;Co-Immunoprecipitations;Corpus striatum structure;Coupled;Curiosities;Diagnosis;Equilibrium;Estradiol;Estrogen Receptors;Estrogens;experimental study;extracellular;falls;Female;G-Protein-Coupled Receptors;Gonadal Steroid Hormones;GPR37 receptor;Hormonal;Hypothalamic structure;Infusion procedures;innovation;insight;Lateral;Link;Measures;Mediating;men;Menopause;Messenger RNA;Modeling;mRNA Expression;Neuromodulator;Neurons;non rapid eye movement;Orphan;Ovariectomy;pharmacologic;Play;Population;Pregnancy;preoptic nucleus;pressure;protein expression;Proteins;Rat Transgene;Rattus;receptor;receptor coupling;Receptor Signaling;Reporting;Role;Sleep;sleep difficulty;Sleep Disorders;Sleep disturbances;Sleep Wake Cycle;Sleeplessness;Surface;Techniques;Testing;Up-Regulation;Viral;Viral Vector;Wakefulness;Woman;women's treatment

PROJECT_TITLE: A Role for the Orphan Receptor, GPR37, in Estradiol-induced Changes in Sleep-Wake States


PHR: [Previous studies suggest that Veterans with a below the knee amputation using passive-elastic or powered prostheses have impaired physical function, which could increase the risk of osteoarthritis, leg/back pain, and diabetes/obesity. Utilization of rehabilitation strategies/techniques such as real-time visual feedback training could restore physical function, increase physical activity, and reduce injury risk. We will systematically determine the effects of using real-time visual feedback training of peak propulsive (push-off) force during walking while Veterans with below the knee amputations use a passive-elastic and battery-powered prosthesis. Similar to previous studies of non-amputee older (>65 years) and post-stroke adults, use of real-time visual feedback training of propulsive force will likely improve walking function in Veterans with amputations. Such training presents a promising rehabilitation strategy that could reduce comorbidities, while improving quality of life, comfort, and physical function, and advancing rehabilitation research and prosthetic development.]

PROJECT_TERMS: Activities of Daily Living;Address;Adopted;Adult;Affect;Amputation;Ankle;ankle joint;ankle prosthesis;Back Pain;Biomechanics;comorbidity;computer monitor;Computers;cost;Degenerative polyarthritis;Development;Diabetes Mellitus;Elasticity;empowerment;Equilibrium;Feedback;Functional impairment;functional improvement;Health;Hip Joint;human old age (65+);Impairment;improved;Injury;Joints;Knee;Knee joint;Leg;limb amputation;Limb Prosthesis;Lower Extremity;Measures;Mechanics;Metabolic;Muscle;Obesity;osteoarthritis pain;Pain in lower limb;pain reduction;Persons;Phase;Physical activity;Physical Function;physical impairment;post stroke;powered prosthesis;Prosthesis;Prosthesis Design;prosthetic foot;Quality of life;Reaction;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;response;Rest;Risk;sensory feedback;Techniques;Technology;Time;Training;treadmill;Veterans;visual feedback;Walking;Work

PROJECT_TITLE: Can Sensory Feedback Training Improve the Biomechanical and Metabolic Effects of Using Passive or Powered Lower Limb Prostheses During Walking for Veterans with Transtibial Amputations?

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: The health of older Veterans is an important priority area for VA. Sleep apnea is a common problem in older Veterans that is associated with poor nighttime sleep, more daytime sleepiness, poor functioning and worse quality of life. The recommended first-line therapy for most patients with sleep apnea is positive airway pressure (PAP) therapy; however, over time many patients who begin PAP therapy no longer use it regularly. This study will test the effects of a novel program for improving use of PAP therapy that is specifically designed for older Veterans with insufficient long-term PAP use. If successful, this approach has the potential to improve sleep, function and quality of life in older Veterans with sleep apnea.

PI_NAMEs: ALESSI, CATHY A (contact)

PROJECT_TERMS: Address;Adverse effects;adverse outcome;Aftercare;airway obstruction;Area;attentional control;Attitude;Behavior Therapy;Behavioral;Cardiovascular Diseases;Caring;Chronic;Clinical;clinical practice;comparison control;cost estimate;COVID-19 pandemic;Data;design;Diabetes Mellitus;Diagnosis;Discipline;Disease;Drowsiness;Education;effective intervention;efficacy testing;Equipment;experience;follow-up;Functional impairment;functional outcomes;future implementation;Goals;Health;health related quality of life;Healthcare Systems;High Prevalence;Hour;human old age (65+);Hypertension;Hypoxia;Impaired cognition;implementation outcomes;improved;improvement on sleep;Individual;Information Systems;innovation;Institution;interest;Intervention;Left;Manuals;Measurement;Measures;Mental Depression;Mental Health;Methodology;Modeling;Newly Diagnosed;novel;novel strategies;Obstructive Sleep Apnea;older adult;Outcome;Outcome Measure;outreach;Participant;Patient Outcomes Assessments;Patients;Personal Satisfaction;physical conditioning;pilot test;Pittsburgh Sleep Quality Index;positive airway pressure;Prevalence;primary outcome;programs;Provider;Psychologist;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;remote grading;remote health care;remote monitoring;remote therapy;Reporting;Research;Risk;Self Management;Services;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep Fragmentations;sleep quality;stroke recovery;Structure;Techniques;telehealth;telemonitoring;Telephone;Testing;Time;tool;treatment as usual;Treatment Efficacy;Veterans;virtual;Work

PROJECT_TITLE: Addressing insufficient positive airway pressure use among older Veterans with obstructive sleep apnea


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;Hematology;Nanotechnology;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The most-used hemophilia treatment is factor concentrate replacement, which is associated with burdensome frequent intravenous infusion. Therefore, developing a less invasive and infrequent dosing therapy for hemophilia is very meaningful. This project aims to develop a novel platform for oral, long-acting mRNA replacement therapy for bleeding disorders.

PI_NAMEs: HAN, XIANGFEI  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: absorption;Address;Amino Acid Transporter;Biodistribution;Biological Availability;biomaterial compatibility;Blood Chemical Analysis;Blood coagulation;Blood Coagulation Disorders;Blood Coagulation Factor;Caco-2 Cells;Circulation;Clinic;Clinical;Coagulation Process;common treatment;COVID-19;cytotoxicity;Development;Diffusion;Doctor of Philosophy;Dose;enzyme replacement therapy;Epithelium;Erythropoietin;Evaluation;Factor VIII;Formulation;Generations;Genetic Diseases;Goals;Half-Life;Hematocrit procedure;Hematology;Hemophilia A;Hepatocyte;Human;improved;In Vitro;in vitro activity;in vivo;Infusion procedures;injection/infusion;innovation;Insulin;intestinal epithelium;Intravenous infusion procedures;Laboratories;Lead;Light;Lipid Chemistry;lipid nanoparticle;Lipids;Liver;Measures;Mediating;Medical;Messenger RNA;Micelles;Modality;Modeling;Monitor;mouse model;mRNA delivery;mRNA Translation;Mucous body substance;Mus;nanoparticle delivery;Nanotechnology;nanotechnology platform;nanotherapy;Nature;novel;novel therapeutics;Oral;Oral Administration;Organ;Patient Compliance;Patients;Pattern;Permeability;Property;Protein Engineering;protein expression;Protein Overexpression;Proteins;Protons;Recombinant Proteins;Recombinants;Replacement Therapy;Reporting;RNA delivery;RNA vaccine;Route;Safety;screening;Series;side effect;Stains;Testing;Therapeutic;therapeutic protein;Tight Junctions;Time;Training;transcytosis;Translations;Transportation;Treatment Efficacy;Work

PROJECT_TITLE: Oral mRNA Nanotherapy for Bleeding Disorder


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative A heart attack occurs when blood supply to the heart muscle is lost, causing cell death, scarring, and long-term structural changes to the heart. We have identified an intracellular protein that regulates scar formation and cell communication after a heart attack. Our goal is to identify therapeautic interventions to improve long-term outcomes for patients.

PI_NAMEs: SHAHEEN, REBECCA J. (contact)

PROJECT_TERMS: Acute;Affect;American;Anterior Descending Coronary Artery;Area;Arrhythmia;Automobile Driving;betaIV spectrin;Binding Sites;Biology;Biomechanics;calmodulin-dependent protein kinase II;Cardiac;Cardiac Myocytes;Cause of Death;Cell Communication;Cell Death;Cell Nucleus;Cells;Cessation of life;chemokine;Chronic;Chronic stress;Cicatrix;Communication;Complex;cytokine;Cytoskeletal Proteins;Data;Deposition;disability;Distant;Environment;Equilibrium;Event;exosome;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Gene Expression;gene function;Generations;Genetic;genetic regulatory protein;Goals;healing;Heart;Heart failure;Hypertrophy;improved;Infarction;Inflammatory;insight;Intercalated disc;Intervention;ischemic injury;Knock-in Mouse;Left;Ligation;Link;Measures;Membrane;migration;Molecular;mouse model;Mus;Myocardial;Myocardial dysfunction;Myocardial Infarction;Myocardium;Myofibroblast;novel;Nuclear;Outcome;paracrine;Paracrine Communication;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;Phenotype;Phosphorylation;Phosphorylation Site;Play;preservation;Prevention;Process;Proliferating;Protein Isoforms;Proteins;recruit;Regulation;repaired;response;response to injury;Risk;Role;Rupture;Sentinel;Signal Transduction;Signaling Molecule;spatiotemporal;Spectrin;Stimulus;Stress;stressor;Stretching;Testing;therapeutic target;Time;Tissues;transcription factor;Transcriptional Activation;Transducers;Vascular blood supply;Work

PROJECT_TITLE: Stress-induced loss of BIV-spectrin regulates cardiac fibroblast function and long-range communication


NIH_SPENDING_CATS: Cerebrovascular;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

ORG_STATE: TN

PHR: The goal of this proposal is to determine the molecular mechanisms that govern cholesterol regulation of the protein termed calcium- and voltage-gated potassium channel of large conductance (BK), and the impact of this regulation on blood vessel diameter in the brain. We will for the first time develop a unifying scheme that explains the actions of cholesterol on the function of BK-forming protein and artery function in the brain at both molecular and cellular levels based on direct binding of cholesterol to the BK channel-forming subunit and/or allosteric regulation secondary to cholesterol interaction with third parties. Considering that cholesterol is prevalent in modern Western diets and has implications for multiple pathological conditions (atherosclerosis, stroke, cognitive deficits including some forms of dementia), the data obtained from this proposal will have high relevance for deepening our understanding of fundamental mechanisms behind these pathologies.

PI_NAMEs: SCHNEIDER, ELIZABETH HOPE (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Address;Adult;Alcohols;Allosteric Regulation;Amino Acid Sequence;Amino Acids;Arteries;Atherosclerosis;Binding;Binding Sites;Biochemical;Biological Assay;Blood flow;Blood Vessels;Brain;Calcium;Cellular Membrane;cerebral artery;cerebrovascular;Cerebrovascular Circulation;cerebrovascular pathology;Cerebrum;Cholesterol;Cognitive deficits;Consensus;Data;Dementia;Dialysis procedure;Diameter;drug of abuse;Electrophysiology (science);Equilibrium;experimental study;Functional disorder;Goals;Homeostasis;hypercholesterolemia;Individual;Knock-in Mouse;Knock-out;Knowledge;large-conductance calcium-activated potassium channels;Life;Ligands;Modernization;Modification;Molecular;Monitor;mouse model;Muscle Cells;Muscle Tonus;mutant;nanoscale;Nutrient;Oxygen;patch clamp;Pathologic;Pathology;Pattern;pharmacologic;Physiological;Physiology;Point Mutation;Protein Family;Protein Isoforms;Proteins;Publishing;rational design;receptor;Recreation;Regulation;Resistance;response;Scanning;Scheme;Secondary to;Site-Directed Mutagenesis;Smooth Muscle;Sterols;Stroke;Systemic blood pressure;Tail;Testing;Time;Tyrosine;United States;Vascular Smooth Muscle;Voltage-Gated Potassium Channel;western diet

PROJECT_TITLE: Cholesterol modulation of BK currents and cerebral artery diameter via channel-forming slo1 subunits


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Cardiovascular;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Infection with Coronavirus-19 results in numerous physiologic derangements, notably with significantly increased risk of endotheliitis. The consequences of endothelial inflammation directly relate to the morbidity of the disease by driving immune-endothelial cellular interactions, microthrombosis, tissue injury, and organ dysfunction. This study will examine the effect of endothelial specific epigenetic modifications by MLL1 in the microvasculature that occur in the post-infectious setting via a new transgenic mouse and novel small molecule endothelial-targeted inhibitor.

PI_NAMEs: PARCHMENT, NATHANIEL  (contact)

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Address;Adhesives;Affect;Anti-Inflammatory Agents;Anticoagulants;Automobile Driving;Biological Assay;Cell Adhesion;Cell Adhesion Molecules;Cell Line;Cells;Characteristics;Chemotactic Factors;Chromatin;Coronavirus;Coronavirus Infections;coronavirus treatment;COVID-19;cytokine;Data Analyses;Development;Disease;DNA;E-Selectin;Edema;Endothelial Cells;Endothelium;Enzymes;Epigenetic Process;epigenetic regulation;Event;Experimental Designs;experimental study;Functional disorder;Gene Expression;Genes;Genetic;Goals;Grant;Hemorrhage;high risk;Histone-Lysine N-Methyltransferase;Histones;ICAM1 gene;Immune;Immune response;In Vitro;in vivo;Infection;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Influenza;inhibitor;Injury;innovation;interstitial;Kidney Failure;Lead;Leukocytes;Lung;Macrophage;Mediating;Mediation;Mediator;Methylation;Mixed-Lineage Leukemia;MLL gene;Modeling;Modification;monocyte;Morbidity - disease rate;mortality;mouse model;novel;Organ;P-Selectin;Patients;Penetration;Permeability;pharmacologic;Phenotype;Physiological;Play;Pneumonia;post SARS-CoV-2 infection;pre-clinical;prevent;Prevention;Production;Promoter Regions;Property;Proteins;recruit;response;Risk;RNA Interference;Role;SARS-CoV-2 infection;Scientist;Secondary to;Signal Transduction;small molecule;Source;System;Techniques;Testing;Thrombosis;thrombotic complications;Thrombus;tissue injury;Tissues;trafficking;Training;Transgenic Mice;vascular bed;Vascular Endothelium;vascular inflammation;Venous;Virus Diseases;Work

PROJECT_TITLE: MLL1 drives collaborative leukocyte-endothelial cell signaling and thrombosis after coronavirus infection


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cardiovascular;Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Heart Disease;Pain Research;Prevention;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative Endometriosis increases the risk of cardiovascular disease, and before this, impairs endothelial function. Women with endometriosis demonstrate increased expression of thromboxane A2 a substance which directly induces vasoconstriction, is an antagonist of nitric oxide synthase activity, and sensitizes sensory afferents in pre-clinical models of cardiovascular disease. The proposed research will determine the role of thromboxane A2 in the regulation of vascular tone in women with endometriosis, providing information that can be directly translated to the development of preventive interventions in this population.

PI_NAMEs: WILLIAMS, AUNI  (contact)

PROJECT_TERMS: Acceleration;Affect;Age;antagonist;Atherosclerosis;attenuation;Blood Platelets;Blood Pressure;blood pressure elevation;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chronic;chronic pain;Coagulation Process;Cutaneous;cyclooxygenase 2;Development;Diffuse;endometriosis;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Event;Exercise;Exposure to;Female;Goals;grasp;Gynecologic;Hand;Impairment;improved;Inflammation;Inflammatory;Ischemia;Lesion;Mediating;Myocardial Infarction;Nitric Oxide;Nitric Oxide Synthase;NOS3 gene;Oral;Pain;Patients;pharmacologic;Physiological;Play;Population;Pre-Clinical Model;pre-doctoral;prevent;preventive intervention;receptor;Reflex action;Regulation;Research;response;Risk Factors;Role;Sensory;Skeletal Muscle;Stimulus;Stroke;systemic inflammatory response;Testing;Thromboxane A2;Thromboxane Receptor;Time;Training;Translating;Up-Regulation;Uterus;Vascular Smooth Muscle;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Vasomotor;Woman

PROJECT_TITLE: The Role of Thromboxane A2 in Vascular Regulation in Women with Endometriosis


ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE Plasmalogen supplementation as a means of replenishing the deficiency of plasmalogens seen in septic patients has the potential to mitigate endothelial oxidative stress and mitochondrial dysfunction. On a larger scale, this may improve survival and reduce organ injury in sepsis patients. The studies herein will examine the mechanism(s) of plasmalogen protection against oxidative stress and identify therapeutic targets in sepsis.

PI_NAMEs: MCGUFFEE, REAGAN  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Admission activity;Angiopoietins;Antibiotic Resistance;Antibiotics;Antioxidants;Bacteria;Bacterial Infections;Biochemical;Blood;cecal ligation puncture;Cell Adhesion Molecules;Cell Compartmentation;Cell membrane;Cell Respiration;Cells;Cellular Membrane;Cessation of life;Characteristics;Choline;Cohort Studies;Collaborations;Complex;Correlation Studies;Coupled;Data;diacetyldichlorofluorescein;Disease;electric impedance;Electron Transport;Electrons;endothelial dysfunction;Endothelium;Endotoxins;Enzymes;Ethanolamines;experimental study;extracellular;Extravasation;fatty acid metabolism;fluorophore;Functional disorder;Glycerol;Health;Heart;Homeostasis;Hospital Costs;Hospital Mortality;Human;Immune response;Impairment;improved;improved outcome;Infection;Inflammation;Inflammatory;Injury;interdisciplinary approach;Kidney;Kinetics;Knock-out;Link;lipid disorder;lipid metabolism;Lipids;Lipopolysaccharides;Liquid substance;Liver;Lung;lung microvascular endothelial cells;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Microvascular Dysfunction;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Molecular Epidemiology;mortality;mouse model;Multiple Organ Failure;Mus;Mycoses;Nature;Organ;Organ failure;organ injury;Outcome;outcome prediction;Oxidants;Oxidation-Reduction;oxidative damage;Oxidative Stress;pathogenic bacteria;pathogenic Escherichia coli;Patient-Focused Outcomes;Pennsylvania;Permeability;Phospholipids;Physicians;Pilot Projects;Plasma;Plasma Cells;Plasmalogens;Positioning Attribute;prevent;Process;Production;Property;Publications;Reactive Oxygen Species;Replacement Therapy;Reporting;Research;Role;Scientist;Sepsis;septic;septic patients;Signal Transduction;Supplementation;Testing;Therapeutic;therapeutic target;Tissues;TLR2 gene;TLR4 gene;tool;Training Programs;Universities;uptake;Vascular Permeabilities;Vertebral column;vinyl ether;Virus Diseases;Visualization;Washington

PROJECT_TITLE: The Role of Plasmalogen Mitochondrial and Endothelial Antioxidant Properties in Sepsis


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Lung;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: Del Mar

ORG_NAME: XFIBRA, INC.

PHR: PROJECT NARRATIVE Pulmonary exposure to chemical warfare agents (CWA), or to industrial pulmonary toxicants (IPT) is a serious unmet medical challenge that impacts the safety of our nation’s civilian population and armed forces that could result in high morbidity and mortality. We are developing an effective medical countermeasure against pulmonary injury, inflammation and fibrosis induced by CWA or IPT, as well as by Acute Respiratory Distress Syndrome and Idiopathic Pulmonary Fibrosis.

PI_NAMEs: BUCK, MARTINA  (contact);CHOJKIER, MARIO

PROGRAM_OFFICER_NAME: YEUNG, DAVID

PROJECT_TERMS: Accidents;Acetaldehyde;Acrolein;Acute Respiratory Distress Syndrome;American;Ammonia;Anti-Inflammatory Agents;Apoptosis;atomic bomb;authority;Biological Markers;Bleomycin;Blood;Bulla;Cells;Certification;Cessation of life;Chemical Models;chemical threat;Chemical Warfare Agents;Chemical Weapons;Chemicals;Chlorine;Choking;Clinical;Clinical Research;clinically relevant;Congresses;Crime;cytokine;Development;Exclusion;Exposure to;Failure;Fibrosis;first responder;Grant;Human;Hydrogen Chloride;Hydrogen Fluoride;idiopathic pulmonary fibrosis;Industrialization;Inflammasome;Inflammation;Inflammatory;Injury;intelligent agent;Iran;Iraq;Israel;Lethal Dose 50;lewisite;London;Lung;lung injury;Macrophage;man;MAP Kinase Gene;Medical;medical countermeasure;Middle East;Military Personnel;Molecular;Morbidity - disease rate;mortality;Mus;Mustard Gas;Myofibroblast;Nerve;new therapeutic target;novel therapeutics;Oxidative Stress;Pathologic;Patients;Peptides;Phase;phase II trial;Phosgene;Phosphorylation;Phosphorylation Site;Population;Pre-Clinical Model;precision medicine;preclinical study;Prevention;Process;Production;Pulmonary Fibrosis;Pulmonary Inflammation;Rattus;Reporting;Risk;Role;Safety;Signal Transduction;Small Business Innovation Research Grant;Smoke;Subway;symposium;System;Technology;Terrorism;Therapeutic;therapeutic target;Tissues;Tokyo;toxicant;Toxicant exposure;Treatment Futility;War;weapons;weapons of mass destruction

PROJECT_TITLE: An Agnostic, Host-Direct Survival Cure MCM for Pulmonary Toxicants.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Cancer;Eye Disease and Disorders of Vision;Prevention;Rare Diseases

ORG_CITY: SAN DIEGO

ORG_NAME: OLMEDA BIOSCIENCES LLC

PHR: Project Narrative Our project aims to create a safer method for predicting uveal melanoma metastatic risk. Instead of invasive biopsies, we use routine aqueous humor paracentesis, ensuring safety and accuracy. Analyzing ocular fluid proteins, we aim to develop a precise test for accurate metastasis risk assessment, enhancing treatment decisions and patient care.

PI_NAMEs: XU, LIYA  (contact)

PROGRAM_OFFICER_NAME: ZANE, LINDA KARINE

PROJECT_TERMS: Address;Adult;Affect;Aqueous Humor;biobank;Biological Assay;Biological Markers;Biopsy;Classification;CLIA certified;Clinical;clinical practice;cohort;Collaborations;comparative;cost;Data;Development;Diagnostic;differential expression;Disease;Distress;Elements;Ensure;Evaluation;experimental study;eye chamber;Eye diseases;follow-up;Future;Gene Expression Profile;Goals;Health Personnel;Hour;Human;improved;indexing;Individual;innovation;Legal patent;Licensing;Liquid substance;Logistic Regressions;Los Angeles;Malignant Neoplasms;Marketing;Medical center;Melanoma patient;Metastatic Melanoma;Methods;Modeling;multiplex assay;Needle biopsy procedure;Neoplasm Metastasis;novel;novel diagnostics;novel strategies;operation;Ophthalmology;Outcome;Paracentesis;Patient Care;Patients;Pediatric Hospitals;Performance;Phase;Preclinical Testing;Price;procedure safety;prognostic tool;protein biomarkers;protein expression;Proteins;Proteomics;protocol development;Protocols documentation;Reaction;Retrospective cohort;Rights;Risk;Risk Assessment;risk prediction;ROC Curve;Safety;sample collection;Sampling;Secure;Sensitivity and Specificity;Site;Small Business Technology Transfer Research;Specificity;Technology;Temperature;Testing;Time;time interval;Tissues;Titrations;tool;Uveal Melanoma;Validation;Variant

PROJECT_TITLE: Development of a Novel Aqueous Humor-Based Multiplex Assay for Uveal Melanoma Metastatic Risk Prediction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BROOMFIELD

ORG_NAME: SIEYAX, INC

PHR: The proposed project is designed to assess the feasibility of advancing a novel small molecule drug candidate into preclinical development as a less toxic, more efficacious drug for treating the major childhood brain cancer, medulloblastoma. This compound inhibits EYA2, which regulates the level of MYC, a key oncogenic driver of many types of cancer that researchers have tried for decades to target without significant success. Thus, the research may have broad applicability to the treatment of numerous MYC- driven cancers.

PI_NAMEs: FORD, HEIDE L. (contact);WANG, XIANG ;ZHAO, RUI

PROGRAM_OFFICER_NAME: FRANCA-KOH, JONATHAN C

PROJECT_TERMS: acute toxicity;Aftercare;Ames Assay;Animal Model;blood-brain barrier crossing;Brain;cancer type;Cell Line;Cell model;Cerebellum;chemotherapy;Chemotherapy and/or radiation;Child;Childhood Malignant Brain Tumor;Classification;Cognitive;Data;Defect;design;Development;Diagnosis;dosage;Dose;drug candidate;Drug Kinetics;drug metabolism;Embryonic Development;Emotional;Endocrine;Ensure;Exhibits;FDA approved;Foundations;Functional disorder;Gene Expression Profile;Genes;Glioblastoma;Grant;Growth;Hand;Hour;Human;Hydrazones;improved;In Vitro;in vivo;inhibitor;knock-down;Lead;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;medulloblastoma cell line;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;MYC gene;Neoplasm Metastasis;Neurologic;new therapeutic target;Normal tissue morphology;novel;Oncogenic;Operative Surgical Procedures;Oral;overexpression;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 2 study;phosphatase inhibitor;Phosphoric Monoester Hydrolases;preclinical development;preclinical study;Prognosis;Property;Protein Tyrosine Phosphatase;Proteins;Publishing;Radiation therapy;Research;Research Personnel;Route;Sampling;scale up;SHH gene;side effect;Small Business Technology Transfer Research;small molecule;Social Problems;Subgroup;success;targeted treatment;Testing;Therapeutic;Tissues;Toxic effect;transcription factor;transcriptome sequencing;Treatment-related toxicity;tumor;Work

PROJECT_TITLE: Preclinical Studies to Develop an Eya2 Tyr Phosphatase Inhibitor as a Novel Medulloblastoma Therapeutic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-T (10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Mental Health;Neurosciences;Stroke

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Cognitive impairment following stroke is emerging as one of the leading causes of disability in the country. Despite large research efforts, there are currently no approved pharmacotherapies for improving functional outcomes following stroke. This proposal aims to uncover molecular mechanisms underlying stroke-induced synaptic and cognitive deficits to identify potential molecular targets for pharmacologic intervention.

PI_NAMEs: BURCH, AMELIA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Address;Adenosine Diphosphate Ribose;Affect;Animal Model;Astrocytes;Attention;Behavioral Assay;Biological Assay;Brain;Brain region;calmodulin-dependent protein kinase II;Cations;Cause of Death;Cell model;cell type;Cells;Central Nervous System;Cerebral Ischemia;Chronic;Clinical Trials;Cognitive;Cognitive deficits;cognitive disability;cognitive load;cognitive process;Country;Data;Dementia;disability;Electrophysiology (science);Endothelium;Ensure;executive function;Exhibits;experience;Family;functional improvement;Health;Healthcare Systems;Hippocampus;Human;Image;Immunofluorescence Immunologic;Impaired cognition;Impairment;improved;In Vitro;in vivo;Infarction;inhibitor;Injections;Intervention;Ion Channel;Ischemia;ischemic injury;Ischemic Stroke;Knock-out;Knockout Mice;Language;Learning;Ligands;Long-Term Potentiation;Measures;Memory;Memory impairment;Microglia;middle cerebral artery;Middle Cerebral Artery Occlusion;mild cognitive impairment;Modeling;Molecular;Molecular Target;molecular targeted therapies;mortality risk;mouse model;Mus;neural network;Neural Pathways;neurobehavioral;Neurologic;Neurons;neuroprotection;neurorestoration;novel;novel therapeutic intervention;Oxidative Stress;Pathology;Pathway interactions;patient population;Patients;pharmacologic;Pharmacotherapy;Phenocopy;post intervention;post stroke;preservation;Procedures;receptor;Recovery of Function;Reperfusion Therapy;Research;restoration;Role;sex;Short-Term Memory;Signal Transduction;Slice;Source;Stroke;Survivors;Symptoms;Synapses;synaptic function;Synaptic plasticity;Therapeutic Intervention;Thrombolytic Therapy;treatment strategy;United States;Up-Regulation

PROJECT_TITLE: CD38 activation of TRPM2 in hippocampal neurons contributes to stroke-induced cognitive dysfunction


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: LEXINGTON

ORG_NAME: CX THERAPEUTICS, INC

PHR: Narrative Cervical insufficiency is a severe complication of pregnancy that can cause a baby to be born prematurely. Preterm birth can cause health problems for the newborn and long-term disabilities during childhood. This project focuses on the development of a novel medical device to reduce preterm birth and improve outcomes for pregnant women with cervical insufficiency.

PI_NAMEs: HOUSE, MICHAEL DOUGLAS (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Adverse effects;Area;biomaterial compatibility;Birth;Carrying Capacities;Cerebral Palsy;Cervical;Cervical Cerclage;Cervix Incompetence;Cervix Uteri;Child;Childhood;Clinical;clinical practice;Clinical Trials;commercialization;Complex;Computer Models;cost;cytotoxicity;design;Development;Device Designs;Devices;Diagnosis;Discipline of obstetrics;Engineering;Ensure;Environment;Excision;experimental study;Failure;fetal;Fetal Growth;Fetus;First Pregnancy Trimester;first-in-human;Goals;Gynecologic;Health;Healthcare;high risk;Human;human study;human tissue;Hysterectomy;improved;improved outcome;In Vitro;in vivo;Infant;Instruction;Laceration;Length;Life;Long term disability;Long-Term Effects;Lung Diseases;manufacturing process;Measurement;Medical Device;Medical Device Designs;meetings;migration;Morbidity - disease rate;Neonatal Mortality;Newborn Infant;novel;Operating Rooms;Operative Surgical Procedures;Outcome;Pathologic Processes;Patient Care;Patients;Pessaries;Phase;Physicians;porcine model;Positioning Attribute;postnatal;Pregnancy;Pregnancy Complications;pregnant;Pregnant Women;premature;Premature Birth;Premature Infant;Premature Labor;prevent;Procedures;Process;product development;Production;prototype;Qualifying;Recording of previous events;Regulatory Affairs;Residual state;Risk;Role;Second Pregnancy Trimester;Secure;Shapes;Silicones;Specific qualifier value;Sterility;Sterilization;Stress;stress reduction;Surface;Surgical sutures;Syndrome;Testing;Therapeutic;Tissues;United States;usability;Uterine Contraction;Vagina;Validation;Weight-Bearing state;Work

PROJECT_TITLE: A Novel Device for Cervical Insufficiency in Pregnant Women

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


ORG_CITY: BIRMINGHAM

ORG_NAME: ENDOMIMETICS, LLC

ORG_STATE: AL

PHR: Project Narratives Heart disease, primarily driven by atherosclerosis, is the leading cause of death in the United States. To address this, our proposal focuses on developing an innovative 3D atherosclerosis model using advanced bioprinting technology. This model accurately replicates the complex, multi-layered structure of human arteries and atherosclerotic plaques, incorporating critical atherosclerotic features. By scaling up the in vitro model, we aim to enhance the reliability of the data generated, enabling improved drug efficacy and toxicity assessments. It is also our assertion that this innovative model will more accurately reflect the viability of novel therapeutics proposed for the treatment of atherosclerosis.

PI_NAMEs: CHEN, JUN  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Address;Advanced Development;Animal Model;Animals;Anti-Inflammatory Agents;Architecture;Arterial Fatty Streak;Arteries;Artificial Intelligence;artificial intelligence model;assay development;Atherosclerosis;Attention;Biocompatible Materials;Biological;Biological Assay;bioprinting;Blood Vessels;BODIPY;Cardiovascular Diseases;Cause of Death;CCL4 gene;Cell Culture System;Cell Culture Techniques;Cell Proliferation;Cells;Cholesterol;Clinical Research;Clinical Trials;Colchicine;Complex;cost effective;cytokine;cytotoxicity;Data;Development;Disease;Disparity;Dose;driving force;drug development;drug efficacy;Drug Evaluation;drug testing;Drug toxicity;effective therapy;effectiveness evaluation;efficacy evaluation;empowerment;Endothelial Cells;Ensure;Environment;Enzyme-Linked Immunosorbent Assay;Ethics;Evaluation;fabrication;Foam Cells;Future;Gene Expression;Genetic Variation;Glues;HDAC6 gene;Heart Diseases;Hepatocyte;high throughput screening;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo Model;Inflammatory;inhibitor;innovation;Interleukin-10;Investigation;Legal patent;Licensing;Macrophage;medication safety;Methods;Modeling;Modernization;nano;novel;novel therapeutics;Organoids;Pathogenesis;Pharmaceutical Preparations;Phosphate Buffer;Play;pre-clinical research;Process;Production;Publishing;Regulation;Reliability of Results;Reproducibility;Research;response;Role;Safety;Saline;Sample Size;scale up;screening;Sirolimus;Smooth Muscle Myocytes;Specificity;Speed;Stains;Standardization;Structure;System;Techniques;Technology;Therapeutic;therapeutic candidate;three dimensional cell culture;three-dimensional modeling;Tissues;United States

PROJECT_TITLE: Atherosclerosis assay development for drug efficacy and cytotoxicity screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (11)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Patient Safety

ORG_NAME: INSIGHTFIL

PHR: Narrative – Medication nonadherence contributes to 45% of treatment failures, 700,000 annual hospitalizations, and one death every 19 minutes, making it responsible for $100B in preventable medical costs per year. To address the need for a cost effective, usable/deployable/scalable, and highly versatile solution for real-time adherence detection at point of care, Insightfil is developing a novel disease and medication-form agnostic technology using Near-Field-Communication (NFC) tags and an accompanying smartphone application to measure medication adherence and reduce non-adherence in home-based settings. This project will advance Insightfil’s medication adherence technology toward commercialization and adoption by investigating its usability and accessibility in different contexts, including acute care, acute care, post-acute care, and outpatient settings.

PI_NAMEs: ACWORTH, EDWARD  (contact);FISHER, KIMBERLY

PROGRAM_OFFICER_NAME: URV, TIINA K

PROJECT_TERMS: Acute;acute care;Address;Adherence;Adoption;Adverse drug event;Algorithms;Ambulatory Care;Architecture;Bulla;Caregivers;Caring;Case Study;Cellular Phone;Cessation of life;Chronic;Clinical;Clinical Trials;Code;Collaborations;commercial launch;commercialization;Communication;cost;cost effective;Deimplementation;design;Detection;Devices;digital medicine;Directly Observed Therapy;Disease;Dose;effectiveness/implementation trial;Electronic Health Record;Electronics;Evaluation;Event;Family;Funding;Health Personnel;Home;Hospitalization;Hospitals;improved;in-home care;innovation;insight;instrument;instrumentation;Insurance Carriers;Investments;Maintenance;Marketing;Measures;Medical Care Costs;medical schools;medication compliance;Medication Errors;medication nonadherence;Methods;Modification;Monitor;National Center for Advancing Translational Sciences;Notification;novel;Optics;Outpatients;Parkinson Disease;Patient Care Planning;patient population;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacy facility;Phase;Physicians;pill;Pilot Projects;point of care;post-COVID-19;Preparation;Privatization;programs;prototype;Public Health;Recording of previous events;Reporting;Research;Resources;Risk;sensor;sensor technology;Small Business Innovation Research Grant;smartphone application;Technology;technology platform;Testing;Therapeutic;Time;tool;Treatment Failure;usability;user centered design;user-friendly;Visit

PROJECT_TITLE: Personalized multi-medication packaging with integrated real-time instrumentation to improve adherence


NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Osteoarthritis;Pain Research;Rehabilitation

ORG_CITY: La Crescenta

ORG_NAME: NEUROMUSCULAR DYNAMICS, LLC

PHR: PROJECT NARRATIVE To serve the roughly 14 million adults in the United States experiencing progressive symptoms of degenerative knee osteoarthritis (OA), this project will produce a randomized clinical trial that demonstrates the efficacy of the Leg Dexerity System as an at-home supplement to nonsurgical management of knee OA and its potential for use in remote therapeutic monitoring and billing. The intent is to demonstrate that leg dexterity training, which trains a user’s proprioceptive and neuromuscular control, can be utilized as clinically informed self-management of knee OA to reduce pain and improve function prior to total knee replacement surgery.

PI_NAMEs: VALERO, ERIKA  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;aged;Aging;anterior cruciate ligament injury;Bar Codes;Blinded;Body Weight decreased;Caring;chronic pain management;Clinic;Clinical;Clinical Trials;cloud platform;Commercial grade;commercialization;Complex;Cortisone;Coupled;Data;Degenerative polyarthritis;design;Development;Devices;dexterity;Disease;Dose;Double-Blind Method;Exercise;experience;Feedback;Female;foot;Foundations;functional improvement;Funding;Goals;Health Insurance Portability and Accountability Act;Home;improved;Income;Industry Standard;Inflammatory Response;Injections;instrument;Intellectual Property;joint injury;Joints;knee mechanics;Knee Osteoarthritis;knee pain;knee replacement arthroplasty;Leg;Legal patent;Link;Locomotion;male;Marketing;Measures;mechanical load;Mobility decline;Monitor;Moon;Morbidity - disease rate;Movement;neuromuscular;neuromuscular training;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;osteoarthritis pain;Outcome Measure;Pain;pain reduction;Participant;Patients;Persons;Phase;Physical therapy;placebo group;Placebos;Planet Mars;portability;Positioning Attribute;pressure;programs;Progress Reports;Proprioception;Quality of life;Randomized;randomized, clinical trials;Recovery;remote health care;Replacement Arthroplasty;Reporting;Research Institute;Self Management;Site;Small Business Innovation Research Grant;software development;Solid;Spinal;Symptoms;System;Tablet Computer;Tablets;Therapeutic;Training;treatment group;trial comparing;United States;United States National Aeronautics and Space Administration;United States National Institutes of Health;wireless;wireless electronic

PROJECT_TITLE: Home-Based Leg Dexterity Trainer for Management of Knee Osteoarthritis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-A (11)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_DEPT: DENTISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research aims to improve the health of women with HIV by utilizing three levels of data (longitudinal data from the Women’s Interagency HIV Study [largest and longest-running longitudinal cohort of women with HIV], alcohol outlet density data from the U.S. Census Bureau’s County Business Patterns, and in- depth interview data from women with HIV) to construct the most comprehensive evidence to date of key relationships between alcohol outlets, alcohol and polysubstance use, and HIV care continuum outcomes among women with HIV. The long-term goal of this research is to inform the implementation of evidence-based alcohol policies to improve the health of women with HIV. This proposal focuses on substance use, HIV care continuum outcomes, racial health disparities and harms among women with HIV, addressing two priority scientific areas outlined in NIDA’s 2022-2026 Strategic Plan and two priority scientific areas outlined in NIDA HIV Research Priority Areas.

PI_NAMEs: YEH, JIH-CHENG  (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Acceleration;Address;Adult;African American;African American population;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol measurement;alcohol misuse;alcohol outlet density;alcohol testing;Alcohols;antiretroviral therapy;Area;Behavior;Black race;Businesses;career;Caring;caucasian American;Censuses;Clinical;Cocaine;Color;Communities;Consumption;Continuity of Patient Care;cost;County;Data;density;Development;Disadvantaged;Dose;drug market;Environmental Risk Factor;Equity;Ethnic Origin;evidence base;experience;Female;Future;Goals;Health;health disparities in women;Hispanic;Hispanic Populations;HIV;improved;innovation;Interview;Latinx;Link;Location;Logistic Regressions;Longitudinal cohort;Low income;Massachusetts;Mediating;men;Methods;minority communities;Modeling;National Institute of Drug Abuse;Neighborhoods;Opioid;Outcome;Participant;Pattern;Perception;Persons;Policies;Policy Maker;polysubstance use;poor communities;Population;population health;prevent;public policy on alcohol;racial difference;racial health disparity;Reporting;Research;Research Personnel;Research Priority;response;Risk;Role;Running;Sales;Source;Stimulant;Strategic Planning;Structural Racism;Structure;substance use;theories;therapy adherence;Tobacco;Treatment outcome;United States;Viral;Viral Load result;Vulnerable Populations;Woman;Women's cohort;Women's Health;Women's Interagency HIV Study;women's outcomes;Work

PROJECT_TITLE: Alcohol Outlet Density, HIV Treatment Outcomes, and Polysubstance Use among Women: A Mixed-Methods Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: Research Triangle Park

ORG_NAME: EPICYPHER, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Gene expression is regulated by the integration of DNA methylation (DNAme) and other chromatin features, including chromatin accessibility, histone post-translational modifications (PTMs), chromatin remodelers, and transcription factor binding. However, our understanding of how DNAme co-occurs (and coordinates) with these features to control gene expression is limited by a lack of reliable genomic tools. Here, EpiCypher is partnering with New England Biolabs (NEB) to develop an ultra-sensitive multiomic mapping technology that delivers high resolution DNAme (5mC/5hmC) profiles at defined chromatin features, providing a powerful new approach to advance our understanding of chromatin regulation and unlock the full potential of epigenetic-targeting therapeutics and diagnostics.

PI_NAMEs: KEOGH, MICHAEL-CHRISTOPHER  (contact);VENTERS, BRYAN J

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Acceleration;Acetylation;Adoption;Antibodies;Bar Codes;Benchmarking;Binding;Bioinformatics;Biological Assay;Biological Markers;Biological Sciences;bisulfite;bisulfite sequencing;Cell Line;Cells;Chemicals;Chromatin;chromatin immunoprecipitation;Cleavage Under Targets and Release Using Nuclease;Clinical;clinical application;Complex;Data;data and analysis portal;Development;Diagnostic;Disease;DNA;DNA analysis;DNA Integration;DNA Methylation;DNA methylation profiling;Dose;Drug Targeting;Epigenetic Process;Epitopes;Exhibits;experimental study;Freezing;Gene Expression;genomic tools;Genomics;high throughput screening;Histones;human embryonic stem cell;inhibitor;innovation;K-562;laboratory development;Letters;Lysine;Malignant Neoplasms;Manuals;Maps;MCF7 cell;Methods;Methylation;methylation pattern;Molecular;Monitor;multiple omics;Nervous System Disorder;New England;next generation;Noise;novel;novel strategies;Nucleosomes;Pharmacotherapy;Phase;Post-Translational Protein Processing;Proteins;Protocols documentation;Regulation;Resolution;response;Sampling;Savings;Services;Signal Transduction;targeted treatment;Technology;Time;Tissues;Titrations;tool;transcription factor;Ubiquitination;user-friendly

PROJECT_TITLE: Ultrasensitive multiomic platform using epitope-targeted DNA methylation mapping


NIH_SPENDING_CATS: Biotechnology;Hematology;Rare Diseases

ORG_CITY: Lawrence

ORG_NAME: NECTAGEN, INC.

ORG_STATE: KS

PHR: The human plasma-based therapeutics market is responsible for therapies that treat a wide range of human diseases, such as idiopathic thrombocytopenic purpura, von Willebrand disease, hemophelia, and primary immunodeficiency, and many others. Because the raw material for these therapeutics is expensive and precious, downstream processing improvements are necessary to make existing therapeutics more cost effective and to drive discovery of new ones. The goal of this project is to apply a novel bioprocess-compatible antibody mimetic platform called the nanoCLAMP for the efficient affinity-purification of human plasma proteins.

PI_NAMEs: SUDERMAN, RICHARD JOHN (contact)

PROGRAM_OFFICER_NAME: RAJAGOPAL, MEENA UMA

PROJECT_TERMS: Address;Affinity;Affinity Chromatography;Albumins;Antibodies;antibody mimetics;Antithrombin III;Automobile Driving;Binding;Binding Proteins;Biochemical;Biological;Biological Products;bioprocess;Blood;Blood Coagulation Factor;Buffers;Caustics;Charge;clinical application;Complement 1 Inactivators;Complex;Complex Mixtures;congenital immunodeficiency;cost;cost effective;Custom;Development;Enzymes;Epitopes;Erythropoietin;Escherichia coli;Exhibits;Fibrinolytic Agents;Generations;Goals;Human;human disease;Idiopathic Thrombocytopenic Purpura;Immunoglobulins;improved;Industrialization;innovation;Lead;Length;Libraries;Ligands;Manufacturer;manufacturing scale-up;Marketing;Methods;Names;Natural regeneration;Nature;novel;Organic solvent product;Outcome;Outcomes Research;Performance;Plant Resins;Plasma;Plasma Proteins;Process;process improvement;Production;protein complex;protein purification;Proteins;Protocols documentation;Reagent;Recovery;residence;Resistance;Sampling;Savings;scale up;Specificity;Technology;Temperature;Testing;Therapeutic;therapeutic protein;Time;tool;Transferrin;Translating;Trypsin;von Willebrand Disease;von Willebrand Factor;Work

PROJECT_TITLE: Development of Custom nanoCLAMP Affinity Chromatography Resins for Fast, Efficient Purification of Plasma Proteins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke;Telehealth

ORG_CITY: IRVINE

ORG_NAME: FLINT REHABILITATION DEVICES

PHR: Project Narrative This research is relevant to public health because it will help support the development and commercialization of the first device for seamlessly enabling remote therapeutic monitoring of home exercise in individuals post stroke. If successful, MiGo Tracker will enable frequent, useful, data-driven interactions between therapists and patients regarding their prescribed home exercise regimen that will lead to improved recovery outcomes. This will provide a pathway to a better life for millions of U.S citizens suffering from motor impairment after stroke and other neurologic injuries.

PI_NAMEs: RUSSELL, IAN MILES (contact)

PROJECT_TERMS: Address;Adherence;Algorithms;Blinded;Bluetooth;Caring;Chronic;Clinic;Clinic Visits;Clinical;Code;commercialization;Communities;Complement;cost;cost effective;Custom;dashboard;Data;design;Detection;Development;Devices;digital;Documentation;Effectiveness;Electronic Health Record;Ensure;Environment;Exercise;exercise adherence;exercise program;exercise regimen;exercise rehabilitation;experience;Feedback;group intervention;Health;Health Insurance Portability and Accountability Act;Home;Hour;implementation barriers;improved;Individual;innovation;Internet;intervention participants;Life;Measures;Medical Device;Medicare;member;mode of exercise;Monitor;motor impairment;Movement;Nervous System Trauma;Neuronal Plasticity;Occupational Therapist;Outcome;Outcome Measure;Outpatients;Participant;Pathway interactions;Patients;Persons;Phase;physical therapist;post stroke;primary outcome;Printing;programs;Public Health;Randomized;Randomized, Controlled Trials;Recovery;Rehabilitation Centers;Rehabilitation therapy;remote interaction;remote monitoring;Research;routine care;Safety;Schedule;secondary outcome;sensor;smartphone application;Stroke;System;Technology;Therapeutic;Time;tool;treatment as usual;United States National Institutes of Health;Upper Extremity;uptake;usual care arm;Video Recording;Wrist

PROJECT_TITLE: MiGo Tracker: Seamless Remote Therapeutic Monitoring of Exercise Adherence After Stroke

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-J (10)]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Kidney Disease;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: 8. Project Narrative HIV infection makes women more vulnerable to heart attacks. We will assess whether SGLT2 inhibitor therapy improves blood flow to the heart, while also reducing fat around the heart, protein in the urine, and inflammation in the blood stream. Our work will inform strategies to prevent heart attacks in women with HIV.

PI_NAMEs: ZANNI, MARKELLA V. (contact)

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: absorption;Adipose tissue;Aging;antiretroviral therapy;Arteries;Atherosclerosis;atherothrombosis;Blood;Blood flow;Blood Vessels;Cardiac;cardiometabolism;cardioprotection;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Clinical;clinical effect;complement C4d;Coronary;Coronary artery;coronary computed tomography angiography;Data;Diabetes Mellitus;Disease;Event;Exclusion;Face;Fatty acid glycerol esters;Glucose;Glucose Transporter;Health;Health education;Healthcare Systems;Heart;Heart failure;High Risk Woman;HIV;HIV Infections;HIV-1;Immune;immune activation;Impairment;improved;indexing;Inflammation;Inflammatory;inhibitor;inhibitor therapy;insight;Intervention;Kidney;Metabolic;Microvascular Dysfunction;Myocardial Infarction;novel;Oxygen;Pathway interactions;patient population;Perfusion;Persons;PET/CT scan;Pharmaceutical Preparations;Population;Positron-Emission Tomography;Predictive Factor;pressure;Prevalence;prevent;Process;Proteins;Publishing;Randomized;randomized trial;Randomized, Controlled Trials;revascularization;Risk;Risk Factors;Sodium;Stream;Stroke;Testing;translational clinical trial;United States National Institutes of Health;Urine;Woman;Work

PROJECT_TITLE: Effects of SGLT2 Inhibition on Coronary Flow Reserve and Other Key Indices Relevant to Type 2 Myocardial Infarction Risk among Women with HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative  More than 100 million new skin scars appear annually in the United States, and scars may cause severe emotional distress and physical disability. Although many products are marketed for scar prevention, their results are modest. If successful, this project will generate major new insights into the cellular and molecular mechanisms controlling scar formation and skin regeneration in mammals. Thus, our work should have broad impact by identifying new strategies to reduce scar formation and to promote tissue regeneration in humans.

PI_NAMEs: LEUNG, THOMAS H. (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Adult;afferent nerve;Antibodies;Architecture;Area;Biological Assay;Biological Process;Cations;cell type;Cells;Cicatrix;Cutaneous;cytokine;Data;Dendritic Cells;Dermal;Distant;Ear;emotional distress;Exhibits;Fibroblasts;Fibrosis;Future;gene product;Genes;Goals;Hair;Hair follicle structure;healing;Human;IL17 gene;Immune;Immunology;improved;In Vitro;in vivo;injured;insight;interleukin-23;Knockout Mice;Light;Mammals;Marketing;Mediating;Modeling;Molecular;mouse model;Mouse Protein;Mus;Natural regeneration;Nerve;Neuroimmune;Neurons;neutrophil;Neutrophil Infiltration;novel therapeutics;old mice;optogenetics;Organ;Parabiosis;paracrine;pharmacologic;physically handicapped;Physiological;prevent;Prevention;Production;receptor;Recombinant Proteins;reconstitution;recruit;Regenerative pathway;replication factor C;Reporting;response;Science;Sebaceous Glands;Serum;Signal Pathway;single cell genomics;single-cell RNA sequencing;Site;Skin;Skin injury;skin regeneration;Skin repair;skin wound;Skin wound healing;Spinal Ganglia;Structure;tau Proteins;Testing;therapeutic development;Thick;tissue regeneration;Tissues;Transcript;United States;Vertebrates;Work;wound;Wound models;γδ T cells

PROJECT_TITLE: Neuroimmune Control of Scarless Skin Regeneration

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pelvic Inflammatory Disease;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

ORG_CITY: WATERTOWN

ORG_NAME: SHERLOCK BIOSCIENCES, INC.

PHR: NARRATIVE When left untreated, STIs such as Chlamydia (infection with C. trachomatis) and Gonorrhea (infection with N. gonorrhoeae) can result in long term adverse health effects that disproportionally affect women, including increasing risk of pelvic inflammatory disease, infertility, and pregnancy complications, however, barriers such as lack of privacy and accessibility to clinical settings, high screening technology price points, and stigma lead women to get screened for STIs less frequently than they would prefer. The proposed study aims to develop a low-cost, PCR-level-accuracy diagnostic device with an easy-to use and read interface for the detection of C. trachomatis and N. gonorrhoeae which can be utilized by the lay consumer at the point of need (at-home) rather than at the point-of-care (in-clinic), creating a more accessible and equitable technology to screen for STIs in women.

PI_NAMEs: WILSON, MARY  (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: accurate diagnostics;Adult;antigen test;Appointment;assay development;biobank;Biological Assay;Biological Sciences;Buffers;Chemicals;Chemistry;Chlamydia;Chlamydia trachomatis;Clinic;Clinical;cost;cost effective;design;Detection;detection limit;Development;Device Designs;Devices;Diagnosis;diagnostic accuracy;Diagnostic Equipment;diagnostic platform;Diagnostic Sensitivity;Diagnostic Specificity;Disproportionately impacts women;Early Diagnosis;Early treatment;Electronics;Elements;Enzymes;Equipment Malfunction;Equity;Failure;Freeze Drying;Frequencies;Fright;Future;Genomic DNA;Goals;Gonorrhea;Habits;Hand;Health;Health Professional;Heating;HIV;Home;home test;Human;improved;Infection;Infertility;Injections;interest;Knowledge;Lateral;Lead;Left;manufacture;manufacturing cost;manufacturing process;manufacturing scale-up;men;Methods;Microfluidic Microchips;Microfluidics;Molds;Molecular;Neisseria gonorrhoeae;novel;Nucleic Acids;Oligonucleotides;Output;pathogen;Pathogen detection;Pelvic Inflammatory Disease;Performance;Phase;point of care;Population;Pregnancy Complications;Price;Privacy;prototype;Reaction;Reaction Time;Reagent;Research;Risk;Sampling;Schedule;screening;self testing;Sensitivity and Specificity;Sexual Health;sexually active;Sexually Transmitted Diseases;social stigma;Specificity;Stigmatization;Swab;Technology;Temperature;Testing;Travel;trial comparing;uptake;Vagina;vaginal infection;Validation;validation studies;Visit;Wait Time;Woman;women's outcomes

PROJECT_TITLE: Ambient Temperature Molecular Detection of Sexually Transmitted Infections from Vaginal Swabs on a Power-free Device

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (13)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Emergency Care;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PEWAUKEE

ORG_NAME: CIAN, INC.

ORG_STATE: WI

PHR: Project Narrative There are around 3 million people in the US that suffer from traumatic brain injury and when undiagnosed or misdiagnosed result in downstream outcomes such as behavioral health problems that can affect quality of life. The objective of this STTR project is to develop a biomarker kit that will assist physicians in monitoring and diagnosing traumatic brain injury.

PI_NAMEs: RAMCHANDRAN, RAMANI  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Accident and Emergency department;Adult;Affect;Affinity;American;Antibodies;Antigens;Appointment;Arl proteins;assay development;Astrocytes;behavioral health;Binding;Biological Assay;Biological Markers;Blood;Blood flow;Blood specimen;Blood Vessels;Brain Injuries;Brain region;care outcomes;Carrier Proteins;cell injury;Cell Line;cell type;Cells;Certification;Cilia;Classification;Clinic;Clinical;Clinical Data;Clinical Laboratory Improvement Amendments;commercial application;Complementarity Determining Regions;Data;Detection;detection assay;Development;Diagnosis;Drops;Drug Prescriptions;Elderly;Emergency department visit;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Evaluation;falls;FDA approved;follow-up;Future;Gender;Generations;Glial Fibrillary Acidic Protein;Goals;Hair;Health;Hospitalization;Hospitals;Hour;Human;humanized monoclonal antibodies;Hybridomas;Immunoassay;improved;injured;Injury;Light;Marketing;medical schools;medical specialties;Microtubules;mild traumatic brain injury;miniaturize;Monitor;Monoclonal Antibodies;Neuroglia;Neuronal Injury;Neurons;novel;Organelles;Outcome;Patient Admission;Patients;Performance;Persons;Phase;Physicians;Plasma;point of care testing;Primary Care;Prognosis;prognostication;Property;Protein C;Proteins;Quality of life;Reader;reagent testing;Recombinants;Reproducibility;research and development;Reverse engineering;Running;Sampling;Scanning;Schedule;shear stress;Small Business Technology Transfer Research;Soldier;Specificity;Sports;Surrogate Markers;TBI Patients;technological innovation;Technology;Testing;tool;trauma centers;Traumatic Brain Injury;treatment effect;Treatment Effectiveness;Triage;ubiquitin C-terminal hydrolase;vascular injury;Vision;Wisconsin;X-Ray Computed Tomography

PROJECT_TITLE: Cilia Biomarker Kit Development for Brain Injury Diagnosis and Prognosis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS), the leading cancer in AIDS patients afflicting the skin and the mucosa of the oral cavity. We will uncover new mechanisms by which KSHV manipulates key metabolic enzymes via protein phosphorylation, thereby reprogramming cellular metabolism to support viral persistence and tumorigenesis. Our project will reveal cellular molecules that can be targeted to thwart KSHV pathogenesis.

PI_NAMEs: ZHAO, JUN  (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;aerobic glycolysis;Anabolism;Anatomy;Aspartate;Automobile Driving;B lymphoid malignancy;Biological;cancer cell;cancer type;Carbamoyl Transferases;Carbamyl Phosphate;Carbon;caspase-activated deoxyribonuclease;Cell Culture Techniques;Cell Line;Cell Proliferation;Cell Reprogramming;Cell Survival;Cells;cellular transduction;Clinical;Clinical Trials;Communicable Diseases;Complex;cyclin-dependent kinase 6;Cyclins;Data;deamidation;Development;Dihydroorotase;Endothelial Cells;enzyme biosynthesis;Enzymes;Etiology;FASN gene;Fatty Acids;Foundations;Glycolysis;Herpesviridae Infections;Homologous Gene;Human;Human Herpesvirus 8;In Vitro;in vivo;Infection;inhibitor;insight;Intervention;Isotopes;Kaposi Sarcoma;keratinocyte;Lesion;Ligase;lipid biosynthesis;Location;Lymphoproliferative Disorders;lytic replication;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;mouse model;Multicentric Angiofollicular Lymphoid Hyperplasia;mutant;Neoplasms;novel;novel therapeutics;nucleotide metabolism;Nucleotides;Oral;Oral cavity;Oral mucous membrane structure;oral tissue;Palate Kaposi's Sarcoma;Pathogenesis;Pathway interactions;Patients;Phosphorylation;Physiological;Post-Translational Protein Processing;primary effusion lymphoma;Production;Prognosis;programs;Proteins;Pyrimidine;Recombinants;recruit;Regulation;Research;research study;response;Role;Skin;Substrate Specificity;Supporting Cell;Therapeutic;Tissue Model;tissue/cell culture;transcription factor;tumor;tumorigenesis;Viral;viral cyclin;Viral Load result;Virion;Virus;Virus Diseases;Virus Replication;Xenograft procedure

PROJECT_TITLE: CDK6-dependent metabolic reprogramming in KSHV pathogenesis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: Madison

ORG_NAME: SALUS DISCOVERY, LLC

PHR: PROJECT NARRATIVE Point-of-care diagnostic testing is key to effective management of tuberculosis (TB), a disease that ranks second in global infectious disease deaths behind COVID-19; however, progress is limited by inherent limitations of current testing methods. This project overcomes current limitations using a novel, yet simple (3 step) and cheap (<$2), assay to enable best-in-class antigen detection for TB diagnosis. In Phase I we will perform assay optimization followed by verification; And in Phase II we will finalize the assay and device manufacturing for clinical evaluations prior to performing said evaluations in preparation for commercialization.

PI_NAMEs: CARRELL, CODY ;WARRICK, JAY WYATT (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: accurate diagnosis;Address;Adult;antigen detection;antigen test;Benchmarking;biobank;Biological Assay;Cambodia;Caring;Cessation of life;Clinical;Clinical Sensitivity;commercialization;Communicable Diseases;cost;Country;COVID-19;Data;Dental Pulp;Detection;detection limit;Development;Device Removal;Devices;Diagnostic;Diagnostic Reagent Kits;diagnostic technologies;Diagnostic tests;Disease;Environment;Enzyme-Linked Immunosorbent Assay;Ethiopia;Evaluation;Excision;Filtration;Formulation;Funding;gaps in access;Geographic Locations;Goals;Health;HIV;Human;Immunoassay;Immunocompetent;Immunocompromised Host;improved;Instruction;instrument;Laboratories;lateral flow assay;Link;low and middle-income countries;low income country;manufacture;manufacturing process;Membrane;Methods;Microscopy;Molds;Mycobacterium tuberculosis;next generation;novel;Nucleic Acid Amplification Tests;operation;Patients;Performance;Phase;point of care;point of care testing;point-of-care diagnostics;Population;Preparation;Recommendation;research clinical testing;Resource-limited setting;Sampling;screening;Silver;Site;Specificity;Syringes;Technology;Testing;Tuberculosis;Tuberculosis diagnosis;tuberculosis diagnostics;Urine;Visual;World Health Organization

PROJECT_TITLE: Flow Direct: Next Generation Urine LFA for TB Diagnosis in Point-of-Care Settings


NIH_SPENDING_CATS: Biomedical Imaging;Congenital Structural Anomalies;Kidney Disease;Pediatric;Polycystic Kidney Disease;Precision Medicine

ORG_CITY: MARIETTA

ORG_NAME: INLIGHTA BIOSCIENCES, LLC

ORG_STATE: GA

PHR: Narratives Our proposed studies will provide a novel avenue in the development of biomarker specific drug candidates for the effective treatment of various human diseases and the developed PET imaging agents will serve as a companion diagnostic for patient risk stratification, and for outcome prediction and novel drug development to enhance clinical care of PKD and other kidney diseases.

PI_NAMEs: GOODMAN, MARK MYRON;MARICHEV, KOSTIANTYN ;YANG, JENNY J. (contact)

PROGRAM_OFFICER_NAME: CONAGE-POUGH, JASON EDWARD

PROJECT_TERMS: activity marker;Adverse effects;Affinity;Agonist;Amino Acids;analog;Animal Model;antagonist;Attenuated;Autosomal Dominant Polycystic Kidney;Binding;Biodistribution;Biological Assay;biomarker development;Calcium;Calcium-Sensing Receptors;Cell Line;Cells;Cessation of life;cinacalcet;Clinical;clinical care;Clinical Trials;Colon;companion diagnostics;Complement;Cystic kidney;design;Development;Disease;Disease Marker;disease model;Disease Progression;Disease regression;Dose;drug candidate;drug development;drug efficacy;Drug or chemical Tissue Distribution;Drug Receptors;effective therapy;extracellular;Extracellular Domain;Family;FDA approved;Fostering;G-Protein-Coupled Receptors;Generations;Goals;Hepatotoxicity;Histologic;Human;human disease;Hyperparathyroidism;Image;imaging agent;imaging capabilities;in vivo;innovation;Kidney;Kidney Diseases;kidney fibrosis;Knowledge;Label;Legal patent;Ligands;Magnetic Resonance Imaging;Maps;Medical;meter;Methodology;microPET;Modeling;molecular imaging;Mus;Mutation;Nausea;Nephrolithiasis;novel;novel drug class;novel marker;novel strategies;novel therapeutics;Organ;Organ Specificity;outcome prediction;Parathyroid gland;Patient risk;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Polycystic Kidney Diseases;Positioning Attribute;positive allosteric modulator;Positron-Emission Tomography;pre-clinical;premature;Procedures;Protein Isoforms;Rattus;receptor;receptor expression;Regulation;Renal Agents;Reporting;Resolution;response;risk stratification;Role;Safety;Scanning;Secondary Hyperparathyroidism;sensor;Severities;Signal Pathway;Site;specific biomarkers;Specificity;Standardization;Structure;success;Testing;testing uptake;Therapeutic;tolvaptan;Tryptophan;uptake;V2 Receptors;Vasopressins;Vomiting

PROJECT_TITLE: Design of Calcium-sensing Receptor Targeted Thera(g)nostic Agents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-Z (10)]