NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Patient Safety;Rehabilitation;Schizophrenia;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project proposes to conduct a study of the functional, neural, and molecular impacts of deprescription of anticholinergic medications in mid- to late-life patients with schizophrenia. The information gathered through this project is of considerable public health significance in that it is expected to yield new insights on how to improve outcomes in the later phases of schizophrenia, identify novel neural and molecular treatment targets to promote long-term recovery, and ultimately reduce the significant public health burden of this disabling psychiatric condition.

PI_NAMEs: EACK, SHAUN M;SARPAL, DEEPAK K (contact)

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: Activities of Daily Living;Address;Adverse effects;Age;Ambulatory Care;Anterior;Anti-Cholinergics;Antipsychotic Agents;Area;arm;basal forebrain;Benztropine;biosignature;Brain;Brain Diseases;Caring;cholinergic;Cholinergic Agents;Chronic;Chronic Disease;Chronic Phase;cingulate cortex;Clinical;clinically relevant;Cognition;Cognitive;cognitive control;cognitive enhancement;cognitive performance;cohort;Data;Diffuse;Disabling;Disease;Dorsal;economic impact;executive function;Facilities and Administrative Costs;follow-up;functional disability;Functional impairment;functional improvement;functional outcomes;Geriatric Psychiatry;Globus Pallidus;Glutamates;gray matter;Health Care Costs;healthy volunteer;Hippocampus;Iatrogenesis;Impaired cognition;improved;improved outcome;indexing;Individual;information gathering;insight;late life;life span;Link;Lived experience;long term recovery;Malignant Neoplasms;Maps;Measures;Mediating;Medicine;Memory;memory encoding;memory retrieval;Molecular;molecular targeted therapies;Morbidity - disease rate;mortality;National Institute of Mental Health;Network-based;neural;neural circuit;Neurocognitive;neuroimaging;neuromechanism;Neurophysiology - biologic function;novel;Outcome;Outcomes Research;Output;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Phase;Polypharmacy;Positioning Attribute;pre-clinical;Prefrontal Cortex;programs;prospective;Prospective Studies;Psychopharmacology;psychosocial;Public Health;Quality of life;randomized controlled design;Randomized, Controlled Trials;Research;Research Personnel;Resistance;response;Risk;Sampling;Schizophrenia;schizophrenia spectrum disorder;secondary analysis;Secondary to;Semantic memory;Serum;side effect;Signal Transduction;societal costs;Source;Strategic Planning;Structure;Syndrome;Task Performances;Testing;therapeutic development;transmission process;treatment adherence;treatment as usual;treatment optimization;Treatment outcome;treatment program;treatment strategy;Underserved Population;United States;verbal;Work

PROJECT_TITLE: Neural Mechanisms of Anticholinergic Burden in Mid- to Late-Life Schizophrenia Spectrum Illness

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Mental Health;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: DIVERSITY SUPPLEMENT – PROJECT NARRATIVE Alcohol use disorder is a heterogeneous disorder with different clinical presentations making the disorder difficult to treat. The aims of this diversity supplement are to explain heterogeneity in alcohol use disorder by leveraging deep behavioral phenotyping to derive neurofunctional domains relevant to addiction, and test these domains on translational alcohol-related endpoints in the human laboratory. The candidate will train in translational science in the field of addiction and professional development to prepare him for an independent research career.

PI_NAMEs: RAY, LARA A. (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: addiction;Address;alcohol craving;alcohol related problem;alcohol response;alcohol use disorder;Alcohols;behavioral phenotyping;biological systems;career;Chronic;Clinical;clinical practice;Cognition;Data;design;Development;Diagnostic;diagnostic criteria;Dimensions;Disease;Emotional;emotional functioning;Executive Dysfunction;executive function;Experimental Designs;Functional disorder;Funding;Genetic Markers;Genotype;Goals;Heterogeneity;Human;incentive salience;Individual;Interoception;knowledge translation;Laboratories;Link;Measures;Mental disorders;Mentors;metacognition;Motivation;National Institute of Drug Abuse;negative mood;Neurobiology;Neurosciences;novel;Parents;Participant;patient subsets;Phenotype;Positioning Attribute;Procedures;Protocols documentation;Psychiatry;Psychology;Psychopathology;Relapse;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Rewards;Sampling;Scientist;screening;Self Administration;Sleep;Sleep Disorders;Testing;Time;Training;training opportunity;translational neuroscience;Translational Research;translational scientist;Translations;Validation;Visit

PROJECT_TITLE: Translational Underpinnings of Motivation for Alcohol in Humans


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The ComPASS Health Equity Research Hub at Yale is a multidisciplinary collaborative of community-engaged researchers that demonstrates the value of integrating diverse perspectives into health equity solutions. Using partnered academic-community teams, the Hub assesses assets and needs, and then tailors and evaluates training and capacity building in research methods, data management, community engagement, and health equity for community-led health equity structural interventions (CHESIs) focused on food/nutrition security, intergenerational family interventions, poverty-reduction, cultural resilience, and participatory research and implementation approaches. Our collaboration long-term goa l is to advance the science of community engagement in with other researchers committed to sustainable health equity.

PI_NAMEs: NUNEZ-SMITH, MARCELLA  (contact);OLADELE, CAROL RENEE

PROGRAM_OFFICER_NAME: MOMIN, BEHNOOSH RAMJI

PROJECT_TERMS: Acceleration;Address;Area;Biometry;career;Collaborations;Communities;community academic partnership;community based participatory research;community collaboration;community engaged research;community engagement;community partners;community partnership;Community-Led Health Equity Structural Intervention;Connecticut;data management;Data Science;Decision Making;design;Ecosystem;Effectiveness;Equity;Evaluation;experience;Faculty;Family;Food;Funding;Generations;Grant;health data;health equity;Health equity research;Health Services Research;implementation science;innovation;interdisciplinary collaboration;interest;intergenerational;Intervention;Knowledge;Lead;Leadership;Learning;Maps;medical schools;member;Methodology;multidisciplinary;nutrition;poverty reduction;Process;programs;Public Health Informatics;Research;Research Design;Research Methodology;Research Personnel;resilience;Role;Scholarship;Science;science and society;Scientist;Security;skills;Specific qualifier value;Strategic vision;Structure;success;Training;United States National Institutes of Health;Universities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-P (52)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases;Natural Products

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative  Experiments to devise new methods to synthesize cyclic peroxides will enable new approaches to prepare this family of potential drugs and explore how they are active as anti-cancer agents. Studies of the reactions involved in organic synthesis and carbohydrate chemistry will help medicinal chemists use such reactions to make biologically active compounds with greater control of three-dimensional structure. These studies are relevant to human health because they could lead to new ways of making medicines.

PI_NAMEs: WOERPEL, KEITH ALLEN (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acetals;Address;Antineoplastic Agents;Apoptosis;Attention;Bacterial Infections;Biochemical Reaction;Biological;Biological Models;Biological Process;Carbohydrate Chemistry;Carbohydrates;Cell Death;cell killing;chemical reaction;Chemicals;Collaborations;design;Disease;Enzyme Inhibitor Drugs;Exhibits;experimental study;Family;Funding;Goals;Health;Human;innovation;Investigation;Ions;Literature;Malaria;Malignant Neoplasms;Medicine;Metabolic;Methods;Natural Products;novel strategies;Organic Synthesis;Pathway interactions;Periodicity;Peroxides;Pharmaceutical Preparations;professor;Property;Reaction;Research;Sialic Acids;Study models;sugar;Synthesis Chemistry;three dimensional structure;Universities;Virus Diseases

PROJECT_TITLE: New Methods for the Synthesis of Biologically Active Compounds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Physical Activity;Prevention;Primary Health Care;Rural Health

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The My Own Health Report (MOHR) intervention is already proven to improve multiple cancer risk factors, including insufficient physical activity and fruit/vegetable intake, as compared to usual care in a randomized trial. This trial will test the comparative impact of the MOHR intervention with two distinct implementation strategy bundles alone or in combination on multi-level outcomes relevant to patients and clinics, including cancer risk effectiveness outcomes, implementation outcomes (including equitable patient reach), and practice value outcomes, such as patient experience and costs. Overall, we expect this work to narrow disparities for multiple cancer risks, and to support scaling out the most cost-effective strategy to improve multiple cancer risks and unmet social needs in other rural primary care clinics.

PI_NAMEs: GLASGOW, RUSSELL E;HUEBSCHMANN, AMY GROTELUESCHEN (contact)

PROGRAM_OFFICER_NAME: GRIMES, GENEVIEVE M

PROJECT_TERMS: Address;Adopted;Adult;arm;Attention;Behavior;behavior change;Behavioral;Cancer Center;Cancer Control;cancer prevention;cancer risk;cancer type;Clinic;Clinic Visits;Colorado;Communities;comparative;comparative effectiveness;contextual factors;cost;cost effective;cost effectiveness;Data;Diet;dietary;Disparity;Educational workshop;Effectiveness;effectiveness outcome;effectiveness/implementation trial;Electronic Mail;Electronics;Equity;experience;field study;flexibility;follow-up;Food;four-arm study;fruits and vegetables;Goals;Health;Health behavior;Healthy Eating;implementation fidelity;implementation outcomes;implementation science;implementation strategy;improved;improved outcome;Inequity;Infrastructure;innovation;Intake;Intervention;Malignant Neoplasms;member;Methods;minority engagement;minority patient;Outcome;Patients;Phase;Physical activity;pilot test;Play;Practical Robust Implementation and Sustainability Model;prevent;Primary Cancer Prevention;Primary Care;primary care clinic;primary care clinician;primary care team;Process;Randomized;randomized trial;Recreation;reduce tobacco use;relative cost;Reporting;Resources;Risk;Risk Behaviors;Risk Factors;Rural;rural area;Services;Signal Transduction;social;Societies;Standardization;Structure;Surveys;Technology;Testing;Text;Time;Tobacco use;tool;Training;treatment as usual;Visit;Voice;web-based intervention;Work

PROJECT_TITLE: Partnering with primary care to address goals of equity, value and sustainment for primary cancer prevention

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative H3K27M DIPGs in children carry a dismal prognosis and have no effective treatments. The imipridone ONC201 shows great promise in early clinical studies. Our goal is to unravel molecular mechanisms that drive response and resistance to ONC201 treatment to facilitate therapeutic development for these deadly cancers.

PI_NAMEs: VENNETI, SRIRAM  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;alpha ketoglutarate;ATAC-seq;Automobile Driving;Biological Assay;Brain Neoplasms;cancer cell;cell growth;Cell Survival;cell type;Cells;Child;Childhood Brain Neoplasm;Chromatin;chromatin modification;Citric Acid Cycle;Clinical;Clinical Research;clinical translation;Clinical Trials;cofactor;Critiques;Data;demethylation;Dependence;Diffuse intrinsic pontine glioma;diffuse midline glioma;Disease;DNA;DNA Methylation;effective therapy;enantiomer;Enzymes;Epigenetic Process;epigenetic profiling;Genes;Genomics;Genus Hippocampus;Glioma;Glutamine;Goals;H3 K27M mutation;Histone H3;Histones;Hypermethylation;Hypoxia;in vivo imaging;inhibitor;Interruption;Isocitrate Dehydrogenase;Knowledge;Location;Lysine;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;Methionine;Michigan;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mutant;Mutation;neoplastic cell;Oncogenes;Oncogenic;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patient Care;Patients;Peptide Hydrolases;Physiological;Positron-Emission Tomography;Production;Prognosis;Reaction;Reporting;Resistance;resistance mechanism;response;Role;Sampling;Stress;Therapeutic;therapeutic development;translational impact;tumor;tumor microenvironment;Universities;Work

PROJECT_TITLE: Unravelling metabolic dependencies in H3K27M mutant DIPG

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Pediatric

ORG_CITY: ATHENS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: Project Narrative - Health relevance The grant proposes to test new treatments for complex sentence knowledge and use, for which there is little in the way of effective intervention. The grant will directly test the efficacy of two approaches to language treatment (explicit training of language rules vs. implicit learning of syntactic structures) and will assess different models of the causal relationships among cognitive factors and treatment outcomes.

PI_NAMEs: GILLAM, RONALD B.;MONTGOMERY, JAMES W (contact);PLANTE, ELENA M

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 11 year old;Academic achievement;academic standard;Affect;Age;Attention;Blood;Books;Child;Clinical;Clinical Treatment;Clinical Trials;clinically relevant;Cognitive;Common Core;Complex;Comprehension;Conscious;cost;Data;Distal;Dose;Education;Educational process of instructing;effective intervention;efficacy testing;evidence base;Evidence based treatment;experience;Failure;Frustration;Grant;Growth;Health;improved;Intelligence;Intervention;Knowledge;Language;language comprehension;Language Development Disorders;language training;Learning;Leisure Activities;Life;Linguistics;Literature;Maps;Mediating;Mediator;Memory;mental representation;Methods;Modeling;movie;Nursery Schools;Oral;Outcome;Outcome Measure;Patient Agents;Pattern;Performance;Population;Prevalence;professor;randomized, clinical trials;Reading;Research;Role;School-Age Population;Schools;Semantics;Severities;Short-Term Memory;skills;social;Social Interaction;Source;statistical learning;Stimulus;Structure;success;syntax;Testing;theories;Thinking;Training;treatment effect;Treatment Effectiveness;Treatment outcome;treatment research;Unconscious State;Vocabulary;Voice;Work;Writing

PROJECT_TITLE: Treating Complex Sentences in Children with DLD

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Services;Infertility;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE One in six people in the United States have infertility, which is treated most effectively with in vitro fertilization (IVF), but health insurance has historically excluded coverage for IVF. Recently, employers have begun adding IVF as a covered benefit for their employees, but, because these new IVF benefits lack a rigorous evidence base, the new benefits can create more harm than good by incentivizing risky, “one-shot” embryo transfer decisions that lead to high-risk twin, triplet, and higher-order multiple births. The proposed research is relevant to public health because 1) it addresses unanswered questions about which IVF benefit designs are most likely to facilitate singleton births, thus improving maternal and infant health, and 2) the results will provide employers and policymakers with the evidence-based guidance they need to create safer insurance coverage for IVF.

PI_NAMEs: DUPREE, JAMES M (contact);KIRKLAND, ANNA RUTHERFORD

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adult;Affect;Age;aged;Birth;Birth Place;Birth Rate;Caring;Characteristics;comparative;cost;Cost Sharing;Couples;Data;Decision Making;design;Disease;Elements;Embryo;Embryo Transfer;Employee;empowerment;Equilibrium;Ethnic Origin;Evaluation;Event;evidence base;Exclusion;experience;Fertilization in Vitro;Goals;Health;Health Expenditures;Health Insurance;Health Promotion;Heterosexuals;high risk;improved;Incentives;Income;Industry;Infant;Infant Health;Infertility;infertility treatment;innovation;Insurance Benefits;Insurance Coverage;Knowledge;Live Birth;Location;Maternal Health;maternal morbidity;maternal outcome;Measures;Methods;Mothers;multidisciplinary;Multiple Birth Offspring;Outcome;Parents;patient oriented;Patient Preferences;Patient-Focused Outcomes;Patients;Persons;Policy Maker;Positioning Attribute;preference;Premature Birth;Prevalence;Probability;Public Health;Qualifying;Race;repository;Research;Research Personnel;Respondent;Risk;Sex Orientation;Survey Methodology;Surveys;Testing;Time;treatment risk;Triplet Multiple Birth;Twin Multiple Birth;Uninsured Medical Expense;United States;Uterus;Woman;World Health

PROJECT_TITLE: How Health Insurance Benefit Design Affects Infertility Treatment and Birth Outcomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cardiovascular;Heart Disease;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: FDA guidelines stipulate that all new drugs be tested for dangerous side-effects on the heart as part of preclinical research; however, the current tests are poorly predictive of both dangerous and safe drugs leading to unwarranted attrition and dangerous drugs reaching clinic. Human cardiomyocytes derived from donor tissue (iPSC-derived cardiomyocytes) are widely considered to hold great promise for clinical trial in a dish studies of drug cardiotoxicity. This STTR proposal is to commercialize a high throughput platform to accurately identify drug candidates that have cardiac side effects, in particular adding the ability to detect the type of primary heart cell damage common with anti-cancer drugs in a fully automated (high throughput) robotic assay for the first time, to improve the efficiency of preclinical research and the safety of human clinical trials, which will also likely have the added benefit of reducing animal research.

PI_NAMEs: PRICE, JEFFREY H. (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Action Potentials;Address;Animal Experimentation;Animal Model;Animal Testing;Animals;Antineoplastic Agents;Arrhythmia;Artificial Intelligence;Biological Assay;Calcium;calcium indicator;cancer recurrence;cancer survival;Cancer Survivor;cancer therapy;cancer type;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;cell injury;Cells;cellular imaging;chemotherapy;Clinic;Clinical;clinical trial in a dish;Clinical Trials;commercialization;Complex;Contractile Proteins;cytotoxicity;Dangerousness;detection assay;dosage;Dose;drug candidate;drug discovery;Drug Industry;Guidelines;Heart;heart cell;Heart Diseases;Human;human induced pluripotent stem cells;Image Cytometry;Impairment;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Kinetics;Label;Malignant Neoplasms;Marketing;Measures;Methods;Microscopy;Mitochondria;Motion;novel therapeutics;Pathologic;Pharmaceutical Preparations;Phase;pre-clinical;Pre-Clinical Model;pre-clinical research;Protocols documentation;Research Contracts;response;Robotics;Safety;Sensitivity and Specificity;side effect;Small Business Technology Transfer Research;Speed;Testing;Therapeutic;therapeutic candidate;Time;Tissue Donors;Treatment Side Effects;validation studies;voltage

PROJECT_TITLE: Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived Cardiomyocytes


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Although immigrants represent a growing, and aging, share of the US population, the state of the science on Alzheimer’s disease and related dementias (ADRD in this population is limited. Research, to date, has not incorporated a life-course approach to study how factors acting early in life, including early in the migration process, accumulate, and/or interact with later life factors to influence biological aging. In this project, researchers leverage comprehensive, longitudinal data from the Multi-Ethnic Study of Atherosclerosis (MESA) and its associated ancillary studies, MESA Neighborhood and MESA MIND, to identify unique life-course acculturation patterns, based on both individual- and neighborhood-level longitudinal data, and evaluate associations with cognition, AD/ADRD biomarkers, and dementia in a population-based sample of diverse, older adults in the US.

PI_NAMEs: ALBRECHT, SANDRA S (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: abeta deposition;Acculturation;Address;adjudication;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Ancillary Study;Behavioral;Biological;Biological Aging;Biological Markers;Cardiovascular Diseases;Cerebrovascular Disorders;Characteristics;Chinese;Clinical;clinically relevant;Code;Cognition;Cognitive;cognitive ability;cognitive function;cognitive performance;cognitive testing;cohort;contextual factors;Country;Data;Data Set;Dementia;dementia risk;Diabetes Mellitus;Digit structure;Environment;Ethnic Origin;executive function;experience;follow-up;Foundations;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Health;Health behavior;Health Promotion;High Prevalence;Hispanic;human old age (65+);Hypertension;Immigrant;Impaired cognition;improved;Individual;insight;instrument;Intervention;late life;Life;Life Cycle Stages;life span;Measurement;Measures;migration;mild cognitive impairment;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;multimodal neuroimaging;Neighborhoods;Nerve Degeneration;Obesity;older adult;Outcome;Pathology;Pattern;Policies;Population;population based;Process;processing speed;Proxy;Publishing;Race;Research;Research Personnel;residence;response;Risk Factors;risk mitigation;Role;Sampling;Science;screening;Short-Term Memory;social;social cohesion;Social Environment;Social Sciences;Socioeconomic Status;socioeconomics;stem;Testing;Time;walkability;Work

PROJECT_TITLE: Life-course acculturation trajectories and dementia in a multi-ethnic cohort of older adults: The MESA Acculturation and dementia Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M1)]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: Boulder

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF COLORADO

PHR: PROJECT NARRATIVE The proposed research is expected to develop a new microphysiological ‘joint-on-chip’ system with structural biomimicry and minimal essential functionality. We will conduct studies to validate the system, and position ourselves for the mechanistic study of arthritic diseases and rapid testing of candidate treatments. The technology will enable future studies of senescence, inflammation, nociception, and metabolism, and support expansion to other tissues and cells in the joint organ.

PI_NAMEs: NEU, COREY P (contact);WHITING, GREGORY

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Allografting;Anti-Cytokine Therapy;Arthritis;Benchmarking;Biochemical;Biocompatible Materials;biofabrication;Biology;Biomechanics;bioprinting;Blood Vessels;bone;Cartilage;cell motility;Cells;Cellularity;Characteristics;Clinical Trials;Colorado;crosslink;cytokine;Degenerative polyarthritis;Development;Disease;drug candidate;Embryo;Engineering;Environment;Enzyme-Linked Immunosorbent Assay;Evaluation;Extracellular Matrix;Fatty acid glycerol esters;fetal;Filtration;Friction;Future;Gene set enrichment analysis;Genes;Goals;Health;Human;human adult stem cell;human model;human stem cells;human tissue;Hyaluronic Acid;Immune;improved;in vivo;Individual;Inflammation;Inflammatory;Injury;Ink;Interleukin-1 beta;Interleukin-6;joint function;Joints;Libraries;lubricin;Measures;Mechanics;Mesenchymal Stem Cells;Metabolism;Methods;miniaturize;Modeling;Movement;Musculoskeletal;Nociception;Ontology;Organ;osteochondral tissue;particle;Particulate;Pathogenesis;Pathogenicity;Pathway interactions;Persons;Pharmacologic Substance;Pharmacotherapy;Phenotype;Physiological;polymerization;Polymers;Positioning Attribute;Printing;Property;rapid testing;Research;response;screening;senescence;Slide;Source;statistics;stem cells;Stimulus;Stretching;Structure;Sulfhydryl Compounds;Synovial Fluid;Synovial Membrane;Synovitis;System;Technology;technology platform;Testing;Time;Tissue Microarray;Tissues;transcriptome sequencing;United States;Viscosity;Work

PROJECT_TITLE: Microphysiological joint-on-chip platform for the study of arthritic diseases

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: FAIRFAX

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: Twenty percent (20%) of the US adult population have contact with the criminal legal system and people with overdose and substance use disorder risk behaviors are overrepresented in the criminal legal system. Engaging and reaching diverse constituents can improve the uptake of evidence-based quality prevention and treatment services. Targeting people with criminal legal system involvement will improve the health and well-being of individuals, families, and communities.

PI_NAMEs: HENDERSON, HOWARD ;MOLFENTER, TODD DAVID;NICKEL, JESSICA HULSEY;PETTUS, CARRIE ;RUDES, DANIELLE SHELDON;TAXMAN, FAYE S (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Achievement;addiction;Address;adjudication;Adult;Behavioral;career;Caring;cohort;Collaborations;Communication;Communities;Community Health;community organizations;community setting;Correctional Institutions;cost;court;design;Development;Discipline;disenfranchised population;education research;Educational Curriculum;Effectiveness;Enrollment;Equity;evidence base;experience;Family;Funding;General Population;Geography;Goals;Government;Grant;Health;health equity;health organization;Historically Black Colleges and Universities;implementation efforts;implementation research;implementation strategy;improved;Individual;innovation;Jail;Justice;K-Series Research Career Programs;Knowledge;Leadership;Legal;Legal system;literacy;Lived experience;Manuscripts;Measures;Methods;minority communities;Names;National Institute of Drug Abuse;outreach;Overdose;overdose prevention;overdose risk;overdose risk behaviors;Participant;Penetration;Personal Satisfaction;Persons;Phase;podcast;Police;Policies;Population;Prevention;prevention service;Prevention strategy;programs;Publications;Publishing;Records;Recovery;Research;Research Personnel;Research Project Grants;response;Risk Behaviors;Running;scale up;Seasons;Services;social stigma;Students;Substance Use Disorder;success;systems research;tailored messaging;Testing;Texas;Translating;Translational Research;Translations;treatment services;treatment strategy;Trust;Universities;uptake;web site;webinar;Wisconsin;Work

PROJECT_TITLE: JCOIN Phase II Coordination and Translation Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-E (M2)]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

PI_NAMEs: TAXMAN, FAYE S (contact)

PROJECT_TERMS: Address;advanced analytics;Artificial Intelligence;Behavior;Benchmarking;Calendar;Characteristics;Collaborations;Communication;Communities;Computer software;Consumption;dashboard;Development;Diffusion;Disabled Persons;E-learning;Education;Elderly;Electronic Mail;English Learner;Enrollment;Ensure;equity, diversity, and inclusion;Ethics;Event;experience;Fentanyl;Frequencies;Funding;General Population;Grant;Health Insurance Portability and Accountability Act;Health Personnel;Home;improved;Individual;Infrastructure;innovation;Jail;Justice;Language;learning community;Legal system;lens;Link;Lived experience;loved ones;Measures;meetings;member;Methodology;Methods;minority communities;minority engagement;Minority Groups;Monitor;National Institute of Drug Abuse;Occupations;opioid use disorder;Output;outreach;Overdose;overdose risk;Persons;Phase;podcast;Policy Maker;Prevention strategy;Prisons;Privatization;Publications;Reader;Reporting;Research;Research Personnel;Resources;Running;Scanning;Science;Seasons;service providers;social media;Special Population;substance use;Substance Use Disorder;substance use prevention;success;symposium;System;Technology;tool;Training;Translations;transmission process;treatment strategy;Update;videoconference;virtual;Visit;web site;webinar

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PI_NAMEs: WILDE, JUDITH  (contact)

PROJECT_TERMS: Address;Adopted;advanced analytics;Advisory Committees;Annual Reports;Applications Grants;Area;Award;Cessation of life;Collaborations;Communities;cost;COVID-19;Data;Development;education research;Evaluation;experience;Family;Family member;Funding;Generations;Goals;Grant;Helping to End Addiction Long-term;Historically Black Colleges and Universities;Hospitalization;Imprisonment;improved;Individual;Infrastructure;innovation;interest;journal article;Journals;Justice;Knowledge;Learning;Legal system;Lived experience;medication for opioid use disorder;Mental Health Services;Methodology;Minority-Serving Institution;Monitor;National Institute of Drug Abuse;novel;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;outreach;Overdose;Paper;Peer Review;Performance;Phase;Pilot Projects;Policies;prevent;Principal Investigator;Procedures;Process;process improvement;programs;prospective;Provider;Public Health;Publishing;recruit;Reporting;Research;Research Personnel;Research Project Grants;research study;Resources;response;secondary analysis;service providers;Services;social health determinants;Speed;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;success;symposium;System;Technology;Time;Translations;tribal college;United States;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;web site;Work;Writing

PROJECT_TITLE: Rapid Response and Pilot Research Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: NICKEL, JESSICA HULSEY (contact)

PROJECT_TERMS: Acceleration;addiction;Adoption;Benchmarking;Berry;career networking;Clinical;clinical practice;Collaborations;Communication;Communities;community engagement;Community Services;community-centered;court;dashboard;Development;disorder risk;Education;Education and Outreach;education research;Educational Curriculum;Enrollment;evidence base;experience;Feedback;Fostering;Future;Goals;Government;Health;health care settings;Health Professional;Health system;Helping to End Addiction Long-term;implementation strategy;improved;Indiana;Individual;innovation;Intervention;Justice;Lead;Leadership;Learning;Legal;Legal system;Link;Lived experience;loved ones;marginalized community;Marketing;medical schools;meetings;member;National Institute of Drug Abuse;Newsletter;online course;Opiate Addiction;Opioid;opioid misuse;opioid use disorder;outreach;Overdose;overdose prevention;overdose risk behaviors;patient engagement;patient oriented;Patients;Persons;Phase;Policies;Prevention;prevention service;Process;Production;programs;prospective;Public Health;Publications;recruit;Reporting;Research;Research Personnel;research study;Resources;Science;Services;Site;Speed;Substance Use Disorder;tool;Training;Translating;Translational Research;Translations;treatment services;Trust;United States National Institutes of Health;Universities;Update;uptake;Voice;web site;webinar;West Virginia;Work

PROJECT_TITLE: Dissemination and Stakeholder Engagement Core


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse

PI_NAMEs: MOLFENTER, TODD DAVID (contact)

PROJECT_TERMS: Address;Adoption;Affect;Area;assessment application;Behavioral;Benchmarking;Climacteric;Communication;Communities;comparative effectiveness trial;Competence;Consolidated Framework for Implementation Research;contextual factors;cost;design;Development;Diffusion;Diffusion of Innovation;Dissemination and Implementation;education research;Educational Curriculum;Elements;Enrollment;Equipment and supply inventories;Evaluation;evidence base;Evidence based program;experience;Feedback;flexibility;Fostering;future implementation;healing;Health Professional;Health system;implementation research;implementation strategy;improved;innovation;Intervention;Interview;Jail;journal article;Knowledge;knowledge translation;Learning;Legal;Legal system;literacy;Measurement;Measures;medication for opioid use disorder;Methods;Misinformation;Modeling;network models;opioid use;Overdose;overdose death;overdose risk behaviors;Participant;peer recovery;Peer Review;Penetration;Persons;Phase;Policies;Population;Prevention;Primary Prevention;Process;Provider;Public Health;Publications;Publishing;Qualitative Methods;Race;Recovery Support;Research;Research Design;Research Personnel;Research Project Grants;research study;Respondent;scale up;Science;Secondary Prevention;Specialist;substance use;Substance Use Disorder;Techniques;Testing;theories;tool;trait;Translating;translational model;translational potential;Translational Research;Translations;trend;uptake;virtual;Work

PROJECT_TITLE: Implementation and Translation Research Project Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

PI_NAMEs: RUDES, DANIELLE SHELDON (contact)

PROJECT_TERMS: Active Learning;addiction;Adoption;Advocate;Applications Grants;Award;Benchmarking;career;Cessation of life;cohort;Collaborations;Communities;Competence;Complex;Credentialing;Criminal Justice;curriculum development;Decision Making;Development;E-learning;Education;education research;Educational Curriculum;Ensure;Ethics;Evaluation Studies;experience;Focus Groups;Fostering;General Population;Goals;Grant;Growth;Health;Health system;Helping to End Addiction Long-term;implementation framework;implementation research;implementation science;implementation study;Imprisonment;improved;Individual;innovation;interest;Intervention;K-Series Research Career Programs;Knowledge;Leadership;Learning;lectures;Legal;Legal system;Lived experience;meetings;member;Mentors;Mentorship;Methods;National Institute of Drug Abuse;Opiate Addiction;Opioid;opioid misuse;Outcome;Overdose;Paper;Participant;Performance;Persons;Pharmaceutical Preparations;Phase;podcast;Policies;Population;Prevalence;Productivity;programs;Public Health;Publications;Publishing;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;responsible research conduct;routine practice;Science;Seasons;Series;Services;skills;Speed;Students;Substance Use Disorder;success;Surveys;symposium;Talents;Training;Training Support;Translating;Translational Research;Translations;United States;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Brain Disorders;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: HENDERSON, HOWARD  (contact)

PROJECT_TERMS: Abate;Access to Information;Address;Adopted;Adoption;Affect;Area;arm;Awareness;Caring;Chicago;Collaborations;Communities;community organizations;Consultations;County;court;cultural competence;Data;Data Collection;design;Development;disadvantaged background;Dissemination and Implementation;E-learning;education research;Empirical Research;empowerment;Epidemic;Equity;Evaluation;Evaluation Studies;evidence base;Funding;Government Agencies;Health;health equity;health inequalities;health organization;Helping to End Addiction Long-term;Historically Black Colleges and Universities;implementation facilitation;implementation strategy;improved;Individual;innovation;interest;Interview;Justice;Knowledge;Lead;learning community;Legal system;Local Government;marginalization;Measures;member;minority communities;Minority Groups;Needs Assessment;Neighborhoods;Nonprofit Organizations;online course;Opiate Addiction;Opioid;opioid misuse;Organizational Innovation;Outcome;outreach;Overdose;overdose prevention;Overdose reduction;Paper;peer;Phase;podcast;Policies;Policy Maker;Prevention;Process;process improvement;programs;Public Health;Recommendation;Research;Research Methodology;Research Personnel;research to practice;Resources;response;service delivery;Services;Speed;State Government;Strategic Planning;substance use;Substance Use Disorder;symposium;System;Texas;tool;Training;Translations;tribal community;United States National Institutes of Health;Universities;uptake;Vertebral column;Veterans;violence prevention;Vision;web site;webinar;Work

PROJECT_TITLE: Technical Assistance Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Public Health Relevance Amblyopia (`lazy eye') is the leading cause of monocular vision loss in children worldwide and affects 3-5% of the population. With current patching treatment, the success rate is about 60-80% with 20-25% recurrence following the treatment, leaving about one third of affected children with amblyopia that persists into adulthood. Visual suppression plays a critical role in developing amblyopia, failure of treatment, and regress following the treatment. This project aims to comprehensively investigate the neural basis of how and where amblyopic suppression occurs in the brain. Understanding the neural mechanisms underlying visual suppression can significantly help prevent and treat amblyopia.

PI_NAMEs: HOU, CHUAN  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adult;Affect;Amblyopia;Anisometropia;Attention;attentional bias;attentional modulation;behavior measurement;Behavioral;Binocular rivalry;Blindness;Brain;Child;Chronic;Coupled;Cues;early childhood;Electroencephalography;Eye;Frequencies;Goals;Image;Knowledge;Lazy Eyes;Measures;Monocular Vision;neural;neural correlate;neuromechanism;Ocular Dominance;Optics;Perception;Performance;Physiological;Play;Population;prevent;Psychophysics;public health relevance;Recurrence;Refractive Errors;Resources;response;Role;selective attention;Signal Transduction;Source;Stimulus;Strabismus;success;Testing;Therapeutic;Treatment Failure;Vision;Visual;Visual attention;Visual Cortex;Visual Perception;Visual Psychophysics

PROJECT_TITLE: Interocular Suppression and Selective Attention in Amblyopia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATVE The Academic Learning Health System Preventions for PRomoting Health Equity (aLHS-PRE) T32 program will provide the next generation of clinician prevention scientists with the methodological and professional skills to conduct rigorous research in complex multi-level environments across multiple domains, including health systems, and to disseminate and implement findings from research into practice, utilizing a framework to reduce health disparities and promote health equity. The aLHS-PRE will offer a predoctoral training experience that will lead to a Master of Science in Learning Health System Science; trainees will conduct a mentored research project that addresses a pressing health system issue. They will be guided by teams of experienced and committed faculty who are subject-matter experts and well-grounded in the principles of effective mentoring.

PI_NAMEs: BERTONI, ALAIN GERALD;TOOZE, JANET A. (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: health equity promotion;Health system;Learning;pre-doctoral;Prevention;Training Programs

PROJECT_TITLE: Academic Learning Health System Preventions for Promoting Health Equity (aLHS-PRE) Predoctoral Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-N (51)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The application of genomics and other specialized evaluation to diagnosis rare human disorders, has been centered in major medical centers. The Undiagnosed Disease Network (UDN) extends the reach of rare disease evaluation and diagnosis by providing access to the undiagnosed patient in all communities. We propose an additional four years of funding for the Pacific Northwest Undiagnosed Diseases Network Clinic (PNW UDN) site to further the goals of the UDN and to provide UDN access for under- or non-insured participants in the Pacific Northwest.

PI_NAMEs: BLUE, ELIZABETH ELOYCE;DIPPLE, KATRINA M;JARVIK, GAIL PAIRITZ (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Adult;Affect;Alaska;Area;autism spectrum disorder;Biochemical Genetics;Bioethics;Bioinformatics;Board Certification;brain malformation;care outcomes;Caring;Childhood;Classification;Clinic;Clinical;clinical diagnostics;Clinical Informatics;Clinical Medicine;clinical research site;clinical sequencing;Clinical Services;Communities;community engagement;community partnership;Computerized Medical Record;Connective Tissue Diseases;Copy Number Polymorphism;Data;Dementia;Dermatology;Diagnosis;Diagnostic;Diagnostic Services;diagnostic strategy;diagnostic tool;Discipline;Disease;disease diagnosis;disease-causing mutation;DNA sequencing;Doctor of Philosophy;Dysmorphology;Education;Environmental Health;Epidemiologist;Epilepsy;Evaluation;experience;Family;Funding;gene discovery;Genetic;genetic architecture;Genetic Diseases;Genetic Predisposition to Disease;genome sequencing;Genomics;Goals;Human;Human Development;human disease;Idaho;Immunology;Improve Access;improved;Infrastructure;Internal Medicine;International;Internist;Knowledge;Leadership;Medical;Medical center;Medical Genetics;medically underserved;Medicine;member;Molecular Diagnostic Testing;Montana;multiple omics;Neonatology;Nerve Degeneration;neurogenetics;Neurology;novel;Oregon;Pacific Northwest;Participant;Pathogenicity;Patients;Pediatric Hospitals;pediatric patients;Pediatrics;Pharmacogenetics;Phase;Physician Executives;Physicians;Policies;Polygenic Traits;Population;Principal Investigator;Program Sustainability;programs;Provider;Rare Diseases;rare mendelian disorder;Records;Reporting;Research;Rheumatology;RNA;Site;Specialist;Technology;Teratology;tool;United States;Universities;Variant;variant detection;virulence gene;Washington;working group;Wyoming

PROJECT_TITLE: Pacific Northwest Undiagnosed Disease Network Clinical Site

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_DEPT: OPHTHALMOLOGY

PHR: The cornea is the part of the visual system most vulnerable to injury from the environment. We have found that photoreceptors sensitive to short-wavelength light are induced in cells on the corneal surface in response to physical injury. This proposal aims to characterize the nature of light-mediated accelerated corneal wound healing and the role of opsin photoreceptors.

PI_NAMEs: BUHR, ETHAN D (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Acute;Affect;Agonist;antagonist;Blindness;Cell Culture Techniques;Cell Line;Cell Proliferation;Cells;Cicatrix;circadian pacemaker;Collaborations;Communication;Cornea;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal regeneration;Darkness;designer receptors exclusively activated by designer drugs;Enterobacteria phage P1 Cre recombinase;Environment;Epithelial Cells;experimental study;Exposure to;Eye;Future;Gene Expression;Genes;Genetic;Goals;healing;Health;Human;Immediate-Early Genes;Impairment;In Vitro;in vivo;Injury;innovation;Knockout Mice;Laboratories;Light;Lighting;LoxP-flanked allele;Macaca;Measures;Mediating;migration;Molecular;Monitor;Motility;mouse model;Mus;Nature;nonhuman primate;novel;Opsin;Optics;paracrine;Paracrine Communication;Phosphorylation;Photoreceptors;Photosensitivity;Physiological;Play;Primates;Proteins;re-epithelialization;Recording of previous events;Regimen;Regulation;Reporter;response;Rest;Retina;Role;Second Messenger Systems;Signal Transduction;Surface;System;Techniques;Testing;Therapeutic;therapeutic target;Tissues;translational potential;Up-Regulation;Viola;Vision;Visual;Visual System;Visualization;Work;wound;wound closure;wound healing

PROJECT_TITLE: Photoreceptor induction in wounded corneas

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative: Type 2 diabetes is a costly disease that is more prevalent in Latino families. This study will test the effects of a diabetes prevention program for Latino families who are at risk for diabetes. We will also look for ways to expand diabetes prevention programs across multiple communities through partnerships.

PI_NAMEs: SHAIBI, GABRIEL QUANTUM (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: access disparities;Address;Adolescent;Adopted;Adult;Area;Arizona;Biological;Body Composition;Child;cohesion;Collaborations;Communities;community organizations;community partners;comparison control;Complex;cost;Cost of Illness;cultural values;Data;Diabetes Mellitus;Diabetes prevention;diabetes prevention program;diabetes risk;Diffusion;Disease;Effectiveness;efficacy testing;empowerment;Evidence based intervention;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Family health status;Family Process;family structure;Funding;glucose tolerance;Glycosylated hemoglobin A;Goals;Health;Health behavior;Health behavior and outcomes;health equity;Health Services Accessibility;high risk;hybrid type 1 design;improved;Individual;Intervention;Latino;Latino Population;learning community;life span;lifestyle intervention;lifetime risk;Link;low health literacy;Mediator;Methods;minority communities;Modeling;Morbidity - disease rate;National Institute of Diabetes and Digestive and Kidney Diseases;neighborhood disadvantage;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Obesity;Outcome;outcome disparities;Parents;peer;Population;Positioning Attribute;Prediabetes syndrome;Predisposition;Premature Mortality;Prevalence;prevent;Prevention;Prevention trial;preventive intervention;psychosocial;Quality of life;Readiness;Research Personnel;resilience;Risk Factors;Series;social;social determinants;System;Testing;Time;Translating;Underserved Population;United States National Institutes of Health;vulnerable community;Vulnerable Populations;Youth

PROJECT_TITLE: Preventing Diabetes in Latino Families-re-entry Supplement


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Diabetes;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PHR: Narrative  Stem cell (SC)-based replacement therapy is emerging as promising cure for diabetes, but the population-wide applicability of this approach remains constrained by the limited efficiency of current protocols of differentiation to produce homogeneous preparations of functionally mature islet tissue. In this collaborative project we integrate knowledge from a team of Investigators with complementary expertise to exploit the power of AI-designed mini-proteins in driving a more efficient differentiation of multiple SC lines into functional islet tissue. We anticipate that our interdisciplinary efforts will produce new knowledge and resources that will collective efforts to broaden the future therapeutic use of SC-based treatments for diabetes.

PI_NAMEs: CIRULLI, VINCENZINO  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acceleration;Address;Artificial Intelligence;Automobile Driving;Benchmarking;Beta Cell;Biochemical;Cell Culture Techniques;Cell Differentiation process;Cell Line;Cell Lineage;cell preparation;Cell Reprogramming;Cell Transplantation;cell type;Cells;Chromatin;Clinical Trials;Communities;Complex;cost;Data;demethylation;Derivation procedure;design;Development;Developmental Biology;Diabetes Mellitus;diabetes mellitus therapy;differentiation protocol;directed differentiation;Discipline;DNA Methylation;DNMT3a;Endocrine;Endoderm;Engraftment;Enzymes;Epigenetic Process;epigenome;ethnic diversity;Ethnic Population;Fostering;Foundations;Future;Gene Expression;Genes;Genetic;Genetic Transcription;histone methylation;improved;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;interest;islet;Islet Cell;Islets of Langerhans;Knowledge;knowledge integration;Link;Metabolic;Methylation;morphogens;novel strategies;Output;Patients;Pattern;Phenotype;pluripotency;Pluripotent Stem Cells;Polycomb;Population;Preparation;Production;progenitor;programs;Proteins;Protocols documentation;Reagent;Regenerative Medicine;Regulation;Replacement Therapy;Reporter;Research Personnel;Resources;screening;Specificity;stem cell differentiation;stem cell fate;stem cell function;stem cell therapy;stem cells;Stress;success;Technology;Testing;Therapeutic;Therapeutic Uses;tissue stem cells;Tissues;trait;transplant model;Transplantation;Validation;Work

PROJECT_TITLE: AI-guided miniproteins driving the production and functional endurance of pancreatic islet tissue from pluripotent stem cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-R (M1)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: PROJECT NARRATIVE Pituitary neuroendocrine tumors (PitNETs) are rare, occurring in approximately 10 per million individuals per year. Despite decades of research, current treatments are suboptimal, and the development of targeted therapies is challenging due to the limited knowledge of PitNET tumor cellular and molecular complexity. The interdisciplinary team science RC2 BioPitNeT project will develop a collection of novel research tools and resources that will enable the rapid and accurate generation of knowledge required for the development of treatment, and prevention of recurrent PitNETs that will ultimately improve the quality of life for patients

PI_NAMEs: LITTLE, ANDREW SCOTT;ZAVROS, YANA  (contact)

PROGRAM_OFFICER_NAME: MALOZOWSKI, SAUL N

PROJECT_TERMS: Acceleration;Acromegaly;Adrenal Glands;Anxiety;Arizona;Atlases;Atrial myxoma with lentigines;Automobile Driving;Benchmarking;biobank;Bioinformatics;biomarker identification;BRAF gene;California;Canis familiaris;Cardiovascular Diseases;CDH23 gene;Cell Line;Cells;Chronic;Classification;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collaborations;Collection;Communities;comparative;Corticotropin;Data;Development;Diabetes Mellitus;Diagnosis;diagnostic tool;Disease;disease model;Disease remission;drug candidate;Drug Screening;effective therapy;Endocrine System Diseases;Exposure to;Fostering;Funding;Future;Generations;Genes;Genetic;Genetic Engineering;genomic data;Health;Hormone secretion;Hormones;Human;human disease;Hydrocortisone;Image;improved;Incidence;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Infrastructure;interdisciplinary approach;Knowledge;Malignant Neoplasms;Medical;Medical center;medical schools;Mental Depression;Mission;Modeling;Molecular;Molecular Genetics;molecular pathology;mortality;mortality risk;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Neuroendocrine Tumors;Neurologic;neuropathology;new therapeutic target;New York;next generation;novel;Obesity;Oncology;open source;Operative Surgical Procedures;Organoids;Outcome;participant enrollment;Pathogenesis;Pathologic;Pathology;Patients;Pediatric Hospitals;Phase;Phenotype;Pituitary Gland;Pituitary Gland Adenoma;Pituitary-dependent Cushing's disease;Pre-Clinical Model;preclinical study;prevent;prognostication;Prolactin;Prolactinoma;prospective;Quality of life;rare cancer;recurrence prevention;Recurrent disease;Recurrent tumor;Registries;Research;Research Personnel;Research Project Grants;Resistance;Resources;Science;Somatotropin;Specimen;Stroke;Structure;study population;System;targeted treatment;therapy development;Tissue imaging;Tissues;tool;Training;transcriptome;translational physician;Translational Research;translational scientist;tumor;tumor behavior;Tumor Tissue;Universities;USP8 gene

PROJECT_TITLE: The National Biorepository and Resource for Pituitary Neuroendocrine Tumor Translational Research (BioPitNeT)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-G (M4)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Latine populations in the U.S. continue to be disproportionately impacted by health disparities, including those related to chronic and infectious diseases. Addressing these disparities requires increasing the diversity of researchers by creating opportunities for rigorous and tailored training in cutting-edge Latine health disparities and health equity research, including multilevel prevention interventions and related methodologies. This is a new application. This application proposes a new T32 doctoral training called ALIADOS (Advanced Training in Latine multi-level Intervention reseArch for DOctoral Scholars; ‘aliados’ is a Spanish term for ‘allies’) to traine diverse doctoral students in Latine health and health disparities and rigorous methods for conducting multilevel- preventive interventions research.

PI_NAMEs: CRESPO, NOE CUAUHTEMOC (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Intervention Studies;Latino;Training

PROJECT_TITLE: ALIADOS: Advanced training in Latino multi-level Intervention reseArch for DOctoral Scholars


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PHR: NARRATIVE Using fixation and naturalistic behavioral paradigms, immersive visual displays of objects, textures and scenes, and recordings with high-density neuropixels probes in the awake macaque monkey, we will achieve a new level of understanding about how visual representations in midlevel stages of the ventral visual stream support perceptual stability even as retinal stimulation changes continuously due to saccades and observer motion. These findings will ultimately bring us closer to devising strategies to alleviate and treat brain disorders of impaired object recognition resulting from dysfunctions in the occipito-temporal pathway (e.g. agnosia).

PI_NAMEs: PASUPATHY, ANITHA  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Agnosia;Animals;area V2;area V4;awake;Behavior Control;Behavioral;Behavioral Paradigm;Brain;Brain Diseases;Brain region;Code;Custom;Data;density;design;Development;Exhibits;experience;experimental study;Eye;Functional disorder;Future;gaze;Grant;Impairment;Individual;Inherited;insight;Joints;Location;Macaca;Maps;Memory;Modeling;Monkeys;Motion;movie;Neurons;neurophysiology;Neurosciences;Neurosciences Research;object recognition;Parietal;Pathway interactions;Perception;Population;Population Dynamics;Positioning Attribute;Primates;Property;prospective;Psychophysics;receptive field;Recording of previous events;response;Retina;retinal imaging;retinal stimulation;retinotopic;Role;Saccades;sample fixation;scaffold;Self Direction;Sensory;Signal Transduction;Source;Specificity;statistics;Stimulus;Surface;System;Texture;V2 neuron;V4 neuron;ventral visual stream;Vision;Visual;visual stimulus

PROJECT_TITLE: The role of area V4 in the perception and recognition of visual objects

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Arctic;Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: ALBUQUERQUE

ORG_NAME: ALBUQUERQUE AREA INDIAN HEALTH BOARD

ORG_STATE: NM

PI_NAMEs: ENGLISH, KEVIN CHARLES (contact);POOLA, CHARLENE

PROGRAM_OFFICER_NAME: SMITH, JACLYN D'ANNE

PROJECT_TERMS: Address;Aftercare;Age;Alaska Native;Alaska Native population;alcohol involvement;Alcoholism;Ally;American Indian Population;Area;behavioral health;Birth;Caring;Colonialism;Colorado;Communities;community based participatory research;contextual factors;COVID-19 pandemic;Data;Data Linkages;data repository;Death Rate;Decision Making;Development;Disparity;Epidemiology;Ethnic Population;experience;Exposure to;Face;falls;Feasibility Studies;Funding;future implementation;Goals;graduate student;Growth;Harm Reduction;Health;Health care facility;health care service;health data;Health Expenditures;Health Personnel;Health Priorities;Health Service Area;Health Services;Health system;Healthcare;Human Resources;Improve Access;improved;improved outcome;Indigenous;information gathering;Inpatients;intergenerational;Internships;Intervention;Knowledge;Life Expectancy;Medicaid;medical specialist;member;Mental Health;Methamphetamine;Modeling;Needs Assessment;New Mexico;Opioid;opioid mortality;opioid overdose;opioid use;Outpatients;Overdose;Pain;Personal Satisfaction;Pharmaceutical Preparations;Phase;pilot test;polysubstance use;Population;Poverty;prevention service;Prisons;professional atmosphere;programs;Provider;public health emergency;Qualifying;racial population;racism;Recovery;recovery services;recruit;Registries;Research;Research Methodology;Research Personnel;Research Priority;resilience;Resources;Rural;service gap;service providers;Services;skills;social;social factors;social stigma;Stereotyping;Strategic Planning;Students;substance use;substance use prevention;substance use treatment;Testing;Texas;Time;tool;Training;training opportunity;Trauma;treatment services;trend;tribal community;tribal health;tribal member;tribal organization;Tribes;undergraduate student;Unemployment;United States;United States Indian Health Service;Utah;Vacuum;Well in self;Wellness Program;Workplace

PROJECT_TITLE: AASTEC-AAIHB N CREW Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 OTHR-6 (01)]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Prevention;Social Determinants of Health

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Narrative [Same as parent award; no change in narrative proposed] Exposure to household air pollution from primitive energy sources (such as charcoal and wood-burning stoves and kerosene lamps) is a top-ten risk factor for morbidity and mortality worldwide. This research will investigate whether a whole-house energy intervention can produce meaningful health benefits for women, men, and children in rural Rwandan homes. Outputs from this work will increase the clinical knowledge-base on the health effects on household air pollution and will generate policy-relevant information on scalable solutions to achieving cleaner, healthier forms of household energy.

PI_NAMEs: CLARK, MAGGIE LYNN (contact);VOLCKENS, JOHN

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Adoption;Adult;Adult women;American;Biomass;Blood Pressure;burden of illness;Carbon Black;Charcoal;Child;Clinical;clinical outcome measures;clinically actionable;cooking;Costs and Benefits;Country;Economics;Energy-Generating Resources;Exposure to;fine particles;Gases;Goals;Growth;Health;Health Benefit;Heating;Home;Hour;Household;Household Air Pollution;Intervention;Kerosene;knowledgebase;Lighting;Link;Marketing;Measurement;men;Modernization;Morbidity - disease rate;mortality;Natural Gas;Output;parent project;Participant;Persons;Petroleum;Policies;Policy Maker;Population;prevent;Privatization;public-private partnership;pulmonary function;Randomized, Controlled Trials;Readiness;Research;Risk Factors;Rural;Rural Health;Rwanda;Solar Energy;solid fuel;Source;Technology;Woman;Wood material;Wood stove;Work

PROJECT_TITLE: Sustainable Household Energy Adoption in Rwanda (SHEAR): Promoting Rural Health with Solar and Natural Gas


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Chronic stress is common and can impair healthy aging. The Stress Network has improved models and measures of stress, and will continue to advance stress science by: 1) improving and promoting the use of harmonized stress measures that enable us to compare stress and health in ten countries; 2) expanding measures of stress including existential global stressors, culture and minority stress, psychosocial resilience, and physiological stress included in our Stress Measurement Toolbox, and; 3) advancing the science of stress reduction using mobile technology through pilot and large scale digital studies. In turn, this will lead to a deeper understanding of how stress affects disease etiology and progression across the lifespan, as well as effective ways to intervene.

PI_NAMEs: EPEL, ELISSA S. (contact);MENDES, WENDY BERRY

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Acceleration;Acute;acute stress;Adopted;Adoption;Affect;Age;age acceleration;age effect;age group;aging related disease;Arousal;Autonomic nervous system;Awareness;behavior change;biobehavior;Biological;career;Cause of Death;Chronic;Chronic stress;climate change;climate crisis;Communities;comparison control;Consultations;Country;Data;digital;digital intervention;digital platform;Disease;Early-life trauma;Educational workshop;Effectiveness;Epidemiology;epidemiology study;Ethnic Origin;Etiology;Funding;Goals;Grant;hackathon;Health;health disparity;healthy aging;Impairment;improved;innovation;insight;Intervention;Intervention Studies;Laboratories;Learning;Life;life span;Link;Measurement;Measures;Medicine;member;Mental Health;Minority Groups;minority stress;mobile computing;Modeling;Morbidity - disease rate;mortality;Onset of illness;Outcome;perceived stress;Personal Satisfaction;Physiological;Physiology;Pilot Projects;Placebo Effect;podcast;Politics;psychologic;Psychological Stress;psychosocial;Psychosocial Stress;Public Health;Publications;Race;Recording of previous events;Recovery;Research;Research Personnel;resilience;Resources;response;Role;Science;Shapes;social;Social Change;social stress;Source;Stress;stress reduction;stressor;Study models;Testing;Trauma;United States National Institutes of Health;Validation;web site;webinar;Work

PROJECT_TITLE: Advancing Psychosocial and Biobehavioral Stress Measurement and Interventions to Promote Healthy Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-9 (M2)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Serious Mental Illness;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Suicide

ORG_CITY: ANCHORAGE

ORG_NAME: ALASKA NATIVE TRIBAL HEALTH CONSORTIUM

ORG_STATE: AK

PI_NAMEs: FORD, TARA  (contact);JESSEN, CORNELIA M

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Agreement;Alaska;Alaska Native;Alaska Native population;Alaska Native Women;Alcohol consumption;Ally;Anxiety;Area;behavioral health;Bipolar Disorder;Canada;Cessation of life;Chemicals;Collaborations;Communities;community based participatory approach;Community Health;community partners;comparative effectiveness;Dancing;data sharing;Depressed mood;depressive symptoms;design;Development;Diagnosis;Disease;Disparity;effectiveness testing;efficacy evaluation;efficacy research;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Exposure to;family structure;Fatality rate;Feeling hopeless;Fentanyl;fetal;Fishes;Foundations;Funding;Generations;Genocides;Goals;gulf coast;Harvest;healing;Health;health disparity;health inequalities;health organization;Health Personnel;Health system;High Prevalence;improved;Indigenous;Individual;Infrastructure;intergenerational;Interruption;Intervention;Intervention Studies;Knowledge;Language;Lead;Leadership;Link;Maps;marijuana use;men;Mental Depression;Mental Health;Methamphetamine;Methodology;Mind;Modeling;Narcotics;native youth;Opioid;opioid use;Oral;Outcome;Outcome Measure;Overdose;overdose death;Pain;pain symptom;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Post-Traumatic Stress Disorders;Prevalence;Prevention;programs;protective factors;psychostimulant;Psychotropic Drugs;Randomized;Randomized, Controlled Trials;Recording of previous events;Reporting;Research;research and development;Research Ethics;Research Personnel;Research Project Grants;Research Training;resilience;Resources;Rest;Rural;rural area;Schools;Science;sedative;Series;Services;skills;statistics;stimulant use;Structure;substance misuse;substance use;Substance Use Disorder;substance use prevention;suicidal;Suicide;Suicide attempt;suicide rate;Time;Training;Trauma;traumatic event;tribal health;tribal organization;Tribes;United States;urban area;Vision

PROJECT_TITLE: Heal(th) From Within: A Research Collaborative to Share our Journeys to Wellness


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Primary Health Care;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE / PUBLIC HEALTH SIGNIFICANCE This project will examine behavioral health integration in community health centers and its association with outcomes for Medicaid enrollees with mental illness. This is important because CHCs provide care for 15 million Medicaid enrollees annually and have been critical partners for Medicaid payment and delivery reforms, including medical homes and care management programs. Understanding the current national landscape of behavioral health integration, its consequences for access to care, patient outcomes, and equity, as well as the factors that may facilitate or hinder integration in health centers will provide actionable information to policy makers to better target resources to reduce costs and improve outcomes for individuals with mental health disorders.

PI_NAMEs: SABBATINI, AMBER KATHLEEN (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Adoption;Adult;Advocacy;behavior measurement;behavioral health;care coordination;care outcomes;care systems;Caring;Case Management;Chronic;Clinic;Clinical;Collaborations;Communities;Complex;Contracts;cost;cost outcomes;Data;Data Element;Data Set;Data Sources;Decision Making;design;disability;Disease;Emergency department visit;Ensure;Equity;evidence base;experience;follow-up;Funding;Health;Health Personnel;Health Services;Health Services Accessibility;Healthcare;Home;hospital readmission;Hospitals;Improve Access;improved;improved outcome;Individual;instrument;Link;Low income;Managed Care;Managed Care Programs;Measures;Medicaid;Medical;medication compliance;Mental disorders;Mental Health;Mental Health Services;Modeling;multilevel analysis;Neighborhood Health Center;novel;Outcome;patient centered medical home;Patient-Focused Outcomes;Patients;payment;Policies;Policy Analysis;Policy Maker;Population;population health;Poverty;predictive modeling;Premature Mortality;Primary Care;primary care practice;primary care setting;Professional Organizations;programs;Provider;Proxy;Public Health;Registries;Research;Resource Allocation;Resources;Role;safety net;Sampling;screening;Services;severe mental illness;Site;Social outcome;Source;substance use;Surveys;System;team-based care;Time;tool;Underserved Population;uptake;waiver;Work

PROJECT_TITLE: Measuring Behavioral Health Integration in Community Health Centers to Improve Access, Equity, and Outcomes for Medicaid Enrollees

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

PHR: Project Narrative Manganese (Mn) is a well-established neurotoxicant and millions of people worldwide are exposed to high levels of environmental Mn from point source emissions or associated fugitive dust. In this proposal, we will investigate associations between environmental Mn exposure and motor, cognitive, and brain MRI imaging outcomes in an established African cohort. If successful, accomplishing these aims will inform environmental regulation of Mn exposure worldwide.

PI_NAMEs: RACETTE, BRAD A (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Accounting;Address;African;Air;air monitoring;Assessment tool;Attenuated;Awareness;Back;Black race;Brain;brain magnetic resonance imaging;Clinical;Clinical assessments;Cognitive;cognitive control;cohort;Communities;Cross-Sectional Studies;Data;data to knowledge;design;dexterity;Diameter;Diffusion;Diffusion Magnetic Resonance Imaging;Dose;Dust;Education;Encephalitis;Environmental Health;environmental justice;Equilibrium;experience;Exposure to;fine particles;Gait;Geography;Health;Image;Impaired cognition;Inflammatory;International;Knowledge;Language;Liquid substance;literacy;longitudinal analysis;Longitudinal Studies;Magnetic Resonance Imaging;Manganese;Manuals;Measures;Mediating;meetings;meter;Moods;Motivation;Motor;Movement Disorder Society Unified Parkinson's Disease Rating Scale;multimodality;National Institute of Environmental Health Sciences;Nerve Degeneration;neuroinflammation;Neurologic;Neurological outcome;Neurologist;neurotoxic;neurotoxicity;Neurotoxins;non-motor symptom;Occupational;Occupational Exposure;Outcome;Outcome Assessment;Parkinson Disease;Parkinsonian Disorders;Participant;particle;Particle Size;Particulate Matter;Pathway interactions;Pennsylvania;Performance;Persons;Phenotype;Policy Maker;preference;Public Health;Questionnaires;Recovery;Regulation;Relaxation;Research;response;Sampling;scientific literacy;Smell Perception;Source;South Africa;South African;spectrograph;Testing;Translations;Universities;validation studies;Work

PROJECT_TITLE: South African Manganese EnvironmentaL NeuroToxic Effects Research (SMELTER)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: PORTLAND

ORG_NAME: OCHIN, INC.

ORG_STATE: OR

PHR: Narrative. The Community Catalyst (Community Climate health equity research center) CCHRC, based on a new partnership between the OCHIN Practice-based Research Network and Harvard’s Confluence Project, will generate the evidence that safety net primary care community health centers (CHCs) need to prepare for and mitigate climate-induced health impacts in marginalized, socioeconomically vulnerable CHC communities. The proposed CCHRC planning process will: generate foundational knowledge on how climate events impact hypertension and asthma incidence and exacerbation in CHC patients, and the patient- and community-level factors that worsen these impacts; and create and support transdisciplinary, community-engaged partnerships that will identify what CHC-led interventions communities prioritize to prepare for and mitigate such impacts, and the research that is immediately needed to assess such interventions’ effectiveness and sustained implementation in CHC populations.

PI_NAMEs: ALBRIGHT, KAREN R;ESTIRI, HOSSEIN ;GOLD, RACHEL  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Address;Air;Area;Asthma;Cardiovascular Diseases;care providers;Caring;catalyst;Censuses;Centers for Population Health;Climate;climate change;climate science;climate-related health;Clinic;Clinical Research;Communities;community engaged research;community engagement;Community Health Networks;community intervention;community led intervention;community organizations;community-level factor;cultural competence;Data;data infrastructure;data resource;Data Set;design;Development;Dissemination and Implementation;effective intervention;Effectiveness of Interventions;effectiveness research;Electronic Health Record;Ensure;Ethnic Origin;Event;experience;Exposure to;extreme heat;Face;Food;Future;Geography;Goals;Health;health disparity;health equity;Health equity research;health information technology;Health Policy;Healthcare Systems;high risk;Housing;Hypertension;Incidence;Individual;Inequity;Infrastructure;innovation;interest;Interruption;Intervention;Investments;Knowledge;Language;Lead;learning community;Link;marginalization;marginalized community;marginalized population;Measures;meetings;Neighborhood Health Center;novel;Outcome;patient oriented;Patients;Pattern;Persons;Point-of-Care Systems;Policies;poor health outcome;Population;Positioning Attribute;Poverty;practice-based research network;Primary Care;primary care clinic;Process;programs;Provider;Public Health;Race;Reduce health disparities;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Research Project Grants;resilience;Resolution;Resources;Risk;safety net;Science;screening;Site;social;social health determinants;socioeconomics;Temperature;Testing;therapy development;Transportation;Trust;Underinsured;Uninsured;United States National Institutes of Health;Variant;vulnerable community;Vulnerable Populations;Wildfire;Work

PROJECT_TITLE: CATALYST (Community ClimATe heALth equitY reSearch cenTer)

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

PI_NAMEs: GOLD, RACHEL  (contact)

PROJECT_TERMS: Acceleration;Air;Budgets;catalyst;Centers for Population Health;Climate;climate change;climate data;climate-related health;Clinical Research;Collaborations;Communication;Communities;community engagement;community engagement process;community partners;Data;data infrastructure;data resource;Data Set;design;Development;Effectiveness of Interventions;Ensure;Evaluation;Event;experience;Exposure to;extreme heat;Funding;Funding Agency;Future;Goals;Health;Health equity research;human subject protection;Informatics;informatics tool;Infrastructure;infrastructure development;innovation;insight;interest;Intervention;Knowledge;Leadership;Learning;learning community;Link;marginalization;marginalized community;meetings;Methodology;Neighborhood Health Center;operation;Organizational Efficiency;Population;Positioning Attribute;practice-based research network;Primary Care;Process;programs;Public Health Informatics;Reporting;Research;Research Personnel;Research Proposals;resilience;Resources;Risk;safety net;Strategic Planning;Structure;success;Time;Translating;Translations;Update;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Lung;Primary Health Care;Social Determinants of Health

PI_NAMEs: ESTIRI, HOSSEIN  (contact)

PROJECT_TERMS: Acute;Address;Adrenal Cortex Hormones;Adult;Affect;Air;Albuterol;Asthma;asthma exacerbation;blood pressure elevation;Cardiovascular Diseases;catalyst;Centers for Population Health;Characteristics;Childhood;Climate;climate change;climate impact;climate-related health;Clinic;Clinic Visits;Code;Communities;community center;community collaboration;community engagement;Community Healthcare;community partners;comorbidity;Data;design;Development;Disease Management;Disparity population;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness research;Event;experience;Exposure to;extreme heat;Feedback;Future;Geographic Locations;Health;health disparity;Health equity research;health inequalities;Hypertension;Incidence;Inequity;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;Kidney;Kidney Diseases;Knowledge;Learning;Link;marginalization;marginalized population;Measures;member;Nebulizer;Neighborhood Health Center;Newly Diagnosed;Oral;Outcome;patient oriented;patient population;Patients;Pattern;Period Analysis;Persons;Population;Positioning Attribute;Primary Care;Process;programs;Pulmonary Heart Disease;Research;Research Priority;Risk;Smoke;social;social health determinants;socioeconomics;Testing;therapy design;United States;Variant;Wildfire

PROJECT_TITLE: Research Program Core


PI_NAMEs: ALBRIGHT, KAREN R (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Air;Applied Research;Area;Asthma;Caring;catalyst;Centers for Population Health;Climate;climate change;climate impact;climate-related health;Collaborations;Committee Members;Communication;Communities;community advisory board;community collaboration;Community Developments;community engagement;community organizations;community partners;community partnership;community research;cultural competence;Data;data infrastructure;data resource;Development;effective intervention;Effectiveness;Effectiveness of Interventions;Elements;Ensure;environmental justice;Evaluation;Event;experience;extreme temperature;Feedback;Focus Groups;Fostering;Funding;Future;Generations;Goals;Health;health equity;Health equity research;Health Services;Health system;Healthcare Systems;Hypertension;improved;Inequity;Infrastructure;Intervention;Interview;Knowledge;Leadership;Learning;learning community;marginalized community;meetings;member;neighborhood disadvantage;Neighborhood Health Center;Outcome;patient oriented;patient population;Patients;Pattern;Policies;Policy Maker;Population;Positioning Attribute;Primary Care;Process;Productivity;programs;Provider;Public Health;Reaction;Research;Research Personnel;Research Priority;Resources;Science;Structure;Translations;Trust;United States National Institutes of Health;Weather;Work

PROJECT_TITLE: Community Engagement Core


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

PHR: Professor Tyler’s research mission is to develop devices and technology that connects directly to a veteran’s nervous system. By directly communicating with the nervous system it is possible to address several significant veteran’s health and quality of life issues that cannot or have not been addressed by drugs or other methods. Dr. Tyler specifically focuses on three significant veteran’s needs - limb loss, hypertension, and spinal cord injury. For veteran’s that have lost a limb, Dr. Tyler is developing technology that provides sensation and naturalistic control of advanced prostheses. The veteran feels like they have either their hand or foot again. For veteran’s with high blood pressure unresponsive to medications, Dr. Tyler’s neural technology applied to the carotid sinus nerve is showing promise in controlling blood pressure. In spinal cord injury, Dr. Tyler’s neural technology restores movement and activation to paralyzed limbs. His technology is helping veterans with paraplegia stand and walk and those with quadriplegia to use their hand.

PI_NAMEs: TYLER, DUSTIN J. (contact)

PROJECT_TERMS: Action Potentials;Address;Advanced Development;Animal Experimentation;Area;Award;Baroreflex;Biomedical Engineering;Blood Pressure;blood pressure control;blood pressure regulation;Bluetooth;Brain;career;career development;carotid sinus;Chronic;Clinical;Clinical Research;clinical translation;Clupeidae;Collaborations;Colorado;Communication;Complex;Computational algorithm;computational neuroscience;density;Dermis;design;Development;Devices;Disease;Doctor of Philosophy;Electrical Engineering;Electrodes;Electromagnetics;Elements;Emotional;Engineering;Esthesia;experience;Eye;fabrication;Florida;foot;functional restoration;Funding;Goals;Government;Grant;Hand;Health;Heart Rate;Histologic;Human;Hypertension;hypertension control;Implant;implantation;improved;indexing;Individual;Industry;Injections;Institution;interest;limb loss;Limb structure;Love;Lower Extremity;Medical center;Mentors;Methods;Michigan;Mission;Modeling;Movement;multidisciplinary;Muscle;nanocomposite;nanopolymer;Nerve;Nervous System;Nervous System Disorder;neural;neural implant;Neurologic Deficit;neuroregulation;Neurosciences;next generation;Paper;Paralysed;Paraplegia;Patients;Pattern;Perception;Peripheral;Peripheral Nerve Stimulation;Peripheral Nerves;Peripheral Nervous System;Pharmaceutical Preparations;Pharmacologic Substance;preclinical development;Privatization;professor;programs;Prostheses and Implants;Prosthesis;Quadriplegia;Quality of life;randomized, clinical trials;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;response;restoration;Role;Science;Scientist;Sea Cucumbers;Secure;Seminal;Sensory;sensory feedback;Services;Shapes;skills;Specialist;Spinal cord injury;Stimulus;Stroke;System;Talents;Techniques;Technology;technology development;Thinking;Tissues;Touch sensation;Translational Research;Translations;Upper Extremity;Veterans;Walking;Wife;Work

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

ORG_STATE: IL

PHR: Relevance to the VA: The VA cares for nearly one million veterans with COPD at a cost of more than $5.5 billion annually. COPD profoundly impairs quality of life as it limits ability to work, to maintain physical exertion and to engage in social activities. Hospital-based rehab can decrease the need for inpatient and outpatient medical care and can improve exercise capacity, quality of life and, possibly, decrease mortality. Unfortunately, access to hospital-based VA rehab is insufficient and, over time, the few veterans who attend experience progressive loss of functional gains. We reason that our proposed home-based exercise program augmented by patient-tailored, RAS-enhanced music will overcome the many limitations of hospital-based rehab. Through our innovative program, we expect to enhance the benefits of rehab and better maintain them over time. The easy applicability of our innovative, accessible and economical program has the potential to modify the spiraling pattern of increasing disability and reduce health-care cost and mortality in veterans with COPD.

PI_NAMEs: LAGHI, FRANCO  (contact)

PROJECT_TERMS: Acoustic Stimulation;actigraphy;Adherence;airway obstruction;Analysis of Variance;Anxiety;Caring;Chronic Obstructive Pulmonary Disease;Clinic;Clinical;comparative efficacy;Control Groups;cost;Coupling;Data;Dimensions;disability;Dyspnea;efficacy evaluation;Eligibility Determination;Emergency department visit;emotional reaction;Enrollment;Ensure;Equipment;Exercise;exercise capacity;exercise intensity;exercise program;Exercise Tolerance;exercise training;Exertion;experience;experimental group;Fatigue;femoral nerve;follow-up;Foundations;Fright;functional gain;functional improvement;functional loss;functional status;Gait;group intervention;Health;Health Care Costs;Health Professional;health related quality of life;Home;Hospitalization;Hospitals;Impairment;improved;innovation;Inpatients;interest;Intervention;Linear Regressions;Lung;Magnetism;Measurement;Measures;Medical;Mental Depression;Methods;Modeling;mortality;Motor;Music;novel;Outcome Measure;Outpatients;participant enrollment;Patients;Pattern;Periodicity;Peripheral arterial disease;Phenotype;Physical activity;Physically Challenged;Physicians;Physiological;primary outcome;programs;Protocols documentation;psychologic;Psychological Factors;Pulmonary function tests;pulmonary rehabilitation;quadriceps muscle;Qualifying;Quality of life;Randomized;Randomized Controlled Clinical Trials;recruit;rehabilitation strategy;Rehabilitation therapy;response;Self Efficacy;Severities;social;Solid;success;symptomatic improvement;Symptoms;systemic inflammatory response;Testing;Time;Training;Transportation;Treadmill Tests;Ultrasonography;Veterans;Visit;Walking;walking speed;Work

PROJECT_TITLE: Increasing Physical Activity in COPD Through Rhythmically Enhanced Music

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE The common skin bacterium Staphylococcus epidermidis is important for maintaining a healthy skin microbiome but can also act as a deadly pathogen, and the difference in these outcomes may be determined by the immense genetic diversity that exists across the many different strains of this single bacterial species. However, the specific genes that contribute to pathogenic processes are still not understood, likely because over 25% of S. epidermidis genes have not been functionally characterized. I propose to overcome this gap in our understanding of S. epidermidis pathogenicity by developing computational tools that will analyze thousands of public datasets and link uncharacterized genes to functionally characterized genes based on correlations in gene expression, the requirement for genes in different growth conditions, and other phenotypic data.

PI_NAMEs: DOING, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Affect;Algorithms;Bacteria;Benchmarking;biological adaptation to stress;Biological Assay;Case Study;Complex;computational pipelines;computerized tools;CRISPR interference;Cues;Data;data integration;Data Set;Dependence;Drug Tolerance;Epidermis;Essential Genes;experimental study;fitness;Gene Expression;gene function;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;Genetic Variation;genome-wide;Genomics;Goals;Growth;Hospitalization;Hospitals;Hour;Human;Human Microbiome;In Vitro;knock-down;Knock-out;Knowledge;Laboratory Finding;Life Style;Link;Machine Learning;member;Methodology;Methods;Microbe;microbial;microbial community;Microbial Genetics;microbiome;Modeling;multiple omics;Mus;Nature;Organism;Outcome;overexpression;pathogen;Pathogenesis;Pathogenicity;Pattern;Phenotype;phenotypic data;Process;Research;response;Role;Skin;skin microbiome;Staphylococcus aureus;Staphylococcus epidermidis;Stress;stress tolerance;stressor;System;Techniques;Technology;Testing;therapeutic target;tool;tool development;transcription factor;transcriptome;transcriptome sequencing;transcriptomics;transfer learning;unsupervised learning;Virulence;whole genome;Work

PROJECT_TITLE: Transcriptomics compendia for the study of strain-level genetic diversity of the human skin microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Repeated interventions are common in adults with congenital heart disease and the standard of care relies on expensive and highly specialized surveillance imaging to optimize timing of intervention. The proposed research uses machine learning methods to analyze the widely available and inexpensive twelve-lead electrocardiogram tracings to study longitudinal ECG changes to predict the need for cardiac intervention, which could be tested against standard of care surveillance imaging. This may lead to a paradigm-shift in the management of adults with congenital heart disease, improving care access and health equity.

PI_NAMEs: BOOK, WENDY M. (contact);SAMENI, REZA

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Adult;Adverse event;adverse outcome;Age;Algorithms;Anatomy;Artificial Intelligence;Atrial Fibrillation;Bayesian Analysis;Biological Markers;Cardiac;Cessation of life;Characteristics;Clinical;clinical biomarkers;Clinical Data;cohort;Computer software;Computerized Medical Record;Confidence Intervals;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Control Groups;cost;Data;Data Analyses;Data Set;Databases;deep learning model;Detection;detection method;Devices;Diagnosis;Dilatation - action;Echocardiography;Electrocardiogram;Ethnic Origin;Evaluation;Event;Evolution;Failure;Fibrosis;Functional disorder;Future;Guidelines;health equity;Health Services Accessibility;Heart;Heart Atrium;heart defect;Heart failure;heart rhythm;Hospitalization;Hypertrophy;Image;imaging study;Imaging Techniques;improved;Individual;innovation;Intensive Care Units;Intervention;Ischemia;Lead;Left;Lesion;Link;longitudinal analysis;Longitudinal Studies;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Magnetic Resonance Imaging;Measurable;medical specialties;Methods;mHealth;Modality;Modeling;Monitor;Myocardial dysfunction;novel;Operative Surgical Procedures;Organ;Outcome;Outpatients;Patients;Pattern;Periodicals;point of care;Population;portability;prevent;Race;Recommendation;repaired;Reporting;Research;Residual state;response;Risk;Sepsis;sex;standard of care;surveillance imaging;Technology;Testing;Time;Time Series Analysis;tool;Training;Travel;Variant;vector;Ventricular;wearable device;X-Ray Computed Tomography

PROJECT_TITLE: Machine Learning Based Analysis of Longitudinal Changes in the Congenital Heart Disease Electrocardiogram

STUDY_SECTION: ASPA

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel A Study Section[ASPA]