NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunization;Orphan Drug;Precision Medicine;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE This project will leverage our institutional experience in tumor profiling and molecular imaging to study the clinical significance of molecular heterogeneity in urothelial cancer, with a focus on the HER2 receptor tyrosine kinase. As a complement to tumor analyses, HER2 PET imaging will be used to study lesion-to-lesion differences in HER2 expression and to determine if patients with heterogeneous HER2 expression are less likely to benefit from treatment with HER2-targeted antibody-drug conjugates (ADCs). Given the promising clinical activity of HER2-targeted ADCs in patients with urothelial cancer, we predict that the studies proposed will accelerate the clinical development of HER2-targeted ADCs and establish a clinical role for HER2 PET imaging as a guide to patient selection. .

PI_NAMEs: IYER, GOPA  (contact);SOLIT, DAVID B.;YEH, RANDY

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Acceleration;anti-PD-1/PD-L1;anti-PD-L1 antibodies;antibody detection;antibody inhibitor;Antibody-drug conjugates;Biopsy;Bladder;Cancer Patient;cancer type;Clinical;clinical development;Clinical Trials;clinically significant;cohort;Complement;Data;Data Set;design;detection sensitivity;Disease;Disease Progression;DNA Sequence Alteration;Drug Targeting;ERBB2 gene;experience;Fibroblast Growth Factor Receptors;Funding;Future;gastroesophageal cancer;Generations;genomic profiling;Genomics;Heterogeneity;Image Guided Biopsy;imaging platform;imaging study;Immune checkpoint inhibitor;improved;individual patient;Institution;Institutional Review Boards;kinase inhibitor;Label;Large-Scale Sequencing;Lesion;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Modeling;Molecular;Molecular Analysis;molecular imaging;Mutate;Mutation;mutational status;Neoplasm Metastasis;novel;novel drug class;Organoids;Outcome;Pathogenesis;Patient Selection;patient subsets;Patients;Pertuzumab;Positron-Emission Tomography;predicting response;predictive marker;Prevalence;Primary Neoplasm;prospective;Protein Overexpression;Radiolabeled;Receptor Protein-Tyrosine Kinases;refractory cancer;Resistance;resistance mechanism;response;response biomarker;Role;Sampling;Site;Specimen;targeted treatment;Technology;Testing;The Cancer Genome Atlas;Therapeutic;Time;Tracer;Transitional Cell Carcinoma;Trastuzumab;treatment response;tumor;uptake;Urothelium;Xenograft Model

PROJECT_TITLE: HER2 PET imaging to assess HER2 heterogeneity and predict response to HER2-targeted ADC therapy in urothelial carcinoma

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW ORLEANS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: Project Narrative Mutations and reduced expression of IRBP are associated with retinitis pigmentosa (RP), childhood-onset retinal dystrophy with high-myopia (CRDHM), cornea curvature, or increased susceptibility to diabetic retinopathy (DR) with unclear mechanisms. Our recent studies in vitro & in a newly developed D1078N knock- in (KI) mouse model of RP revealed that both the CRDHM (E1152x)- & RP (D1080N)-associated mutations abolished the function of IRBP, thereby causing aberrant visual cycle, severe vision impairment, as well as progressive degeneration of rod & cone photoreceptors (PRs) in the KI model of RP. In this proposal, we will elucidate the mechanisms by which the mutations abolish the function of IRBP and explore pharmacological interventions to preserve IRBP function, PRs & vision in the mouse models of the diseases.

PI_NAMEs: JIN, MINGHAO  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acceleration;Amino Acid Substitution;Amino Acids;Amyloid;Animal Model;Apoptosis;Aromatic Amino Acids;Attenuated;Binding;Biological Markers;Blindness;C-terminal;Carrier Proteins;Cell Culture Techniques;Cell Death;cell growth;Cell Line;Cells;Cessation of life;Charge;Chemicals;Child;Childhood;cold temperature;Complex;Computer Analysis;Cone;Cornea;Cultured Cells;Cyclic GMP;cytokine;cytotoxic;cytotoxicity;Dark Adaptation;Data;Defect;Development;Diabetic Retinopathy;diphenyleneiodonium;Disease;disease model;disease phenotype;disulfide bond;Endoplasmic Reticulum;endoplasmic reticulum stress;Essential Amino Acids;Exhibits;Eye;Functional disorder;Goals;Growth;Hybrids;Hydrophobicity;improved;In Vitro;in vivo;Inflammation;Inflammatory;innovation;interstitial retinol-binding protein;Intervention;Knock-in;Knock-in Mouse;Knowledge;Link;link protein;Mediating;Modeling;Molecular;Molecular Chaperones;mouse model;Mus;mutant;Mutate;Mutation;Myopia;NADPH Oxidase 1;Naphthoquinones;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;Nitric Oxide Synthetase Inhibitor;NOS1 gene;novel therapeutic intervention;Opsin;oxidative damage;Oxidative Stress;Pathogenicity;Pathologic;Pathway interactions;Patients;pharmacologic;Photophobia;Photoreceptors;Play;Predisposition;preservation;prevent;protein function;Protein Kinase Interaction;Protein Secretion;Proteins;Reagent;Receptor-Interacting Protein;Recovery;response;Retina;Retinal Cone;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Retinitis Pigmentosa;Retinoids;Rod;Role;Signal Transduction;Signaling Protein;Stress;Structural Protein;Testing;therapeutically effective;TNF gene;TNFRSF1A gene;trafficking;Tryptophan;tryptophan analog;Up-Regulation;valosin-containing protein;Vertebrate Photoreceptors;Vision;visual cycle;Visual impairment

PROJECT_TITLE: IRBP in the visual cycles and retinal diseases

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: KANSAS CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project narrative The proposal will analyze in detail 5'-human-HBV-3' RNAs transcribed from integrated HBV DNA independently of HBV genome replication and examine their (i) sequence features, (ii) accumulation and stability, (iii) ability to regulate the levels of HBV genome replication, and (iv) potential to alter the host genes' expression profile. Overall, the proposed study will advance our understanding of the natural 5'-human-HBV-3' RNAs' sequences organization, their biological functions and role in HBV life cycle.

PI_NAMEs: GUDIMA, SEVERIN O (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: Affect;anti-hepatitis B;Area;Biological Assay;Biological Process;Cell Line;Cells;Chromosomes;Chronic;Chronic Hepatitis B;Circular DNA;Code;Data;design;DNA;DNA biosynthesis;DNA Integration;DNA Repair Enzymes;ds-DNA;Ensure;env Gene Products;Event;experimental study;FDA approved;Gene Expression;Gene Expression Profile;Genes;Genetic Recombination;Genetic Transcription;Genome;Hand;Harvest;Hepatitis B;Hepatitis B Acquisition;Hepatitis B Infection;Hepatitis B Virus;Hepatocyte;HepG2;Human;Human Genome;Hybrids;In Situ;Infection;integration site;Left;Length;Life Cycle Stages;Liver;Location;Maps;Mediating;Messenger RNA;Nucleotides;Pathogenesis;Persons;Pharmaceutical Preparations;Plasmids;Poly A;Polyadenylation;Positioning Attribute;Primary carcinoma of the liver cells;promoter;Property;recombinant virus;Relaxation;Research;Reverse Transcription;Risk Factors;RNA;RNA primers;RNA Sequences;RNA Splicing;RNA Stability;Role;Sampling;Side;Signal Transduction;Site;Specificity;Surface Antigens;Time;Tissue Sample;Tissues;Transcript;transcriptome sequencing;Transfection;vector;viral DNA;Viral Genome;Virion;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Characterization of 5'-human-HBV-3' RNA species transcribed from integrated HBV DNA

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Tobacco;Tobacco Smoke and Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Bronchiectasis is an abnormal enlargement of the airways. We will use an automated approach to identify bronchiectasis on lung images and study its changes over time. We will then assess the association of those changes with lung function and identify people at risk of bronchiectasis worsening on lung images.

PI_NAMEs: DIAZ, ALEJANDRO  (contact);SAN JOSE ESTEPAR, RAUL

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Adult;Advanced Development;Affect;Age Years;airway obstruction;Arteries;Artificial Intelligence;Biological Markers;Blood;Blood Proteins;Blood Vessels;Bronchiectasis;Cause of Death;chest computed tomography;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;cohort;Consumption;Coupled;Data;Development;Diameter;Disease;disease phenotype;Disease Progression;effectiveness validation;Evaluation;exercise capacity;follow-up;health related quality of life;Healthcare;high risk;human old age (65+);Image;Imaging Device;imaging modality;Incidence;Individual;Inflammation;insight;Intervention;Length of Stay;Lung;Lung Diseases;lung imaging;Measurement;Measures;Morphology;mortality risk;Outcome;Participant;Pathogenesis;Pathologic;Patient Care;Patients;Persons;Population;Populations at Risk;Prevalence;progression risk;Protein Array;protein biomarkers;Proteomics;pulmonary function;Pulmonary vessels;Quality of life;radiological imaging;Risk;Role;Sampling;Scanning;Severities;Smoker;Smoking;stem;Surrogate Endpoint;Technology;Testing;Time;tool;Training;United States;Visual;X-Ray Computed Tomography

PROJECT_TITLE: Clinical implications and Proteomics of Bronchiectasis Progression in Smokers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EPH-A (02)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE  Monoclonal B-cell lymphocytosis (MBL) is a common condition that increases risk of cancers and infections. However, the causes, consequences, and clonal trajectories of MBL remain understudied due to the cost and requirement for fresh biospecimens to detect MBL. We propose to develop and validate a strategy to predict MBL status and clonal growth from SNP array data readily available to many large biobank and cohort studies.

PI_NAMEs: GRIFFIN, ROSALIE  (contact);SEKAR, ASWIN

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Adult;adverse outcome;Affect;African American;African ancestry;Age;autosome;B-Lymphocytes;biobank;Blood;Blood specimen;Cancer Control;cancer risk;Cell Count;Cell Fraction;Chromosome abnormality;Chronic Lymphocytic Leukemia;Classification;Clinical;Clone Cells;cohort;Cohort Studies;Confidence Intervals;Copy Number Polymorphism;cost;Data;Data Set;Development;Diagnosis;Discrimination;DNA;empowerment;Etiology;European ancestry;Event;Family history of;Flow Cytometry;Future;General Population;Genetic;Genome;Genotype;Goals;Growth;Hematology;Hematopoiesis;Hospitalization;improved;Incidence;Individual;Infection;Investigation;Knowledge;Location;Loss of Heterozygosity;Lymphocytosis;Malignant lymphoid neoplasm;Malignant Neoplasms;model generalizability;Modeling;Monitor;mosaic;Odds Ratio;Outcome;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;phenome;Population Heterogeneity;Precancerous Conditions;predictive modeling;premalignant;Prevention;Public Health;Risk;Risk Factors;Risk Marker;risk stratification;Sampling;screening;sex;SNP array;Solid;Stratification;study population;Time;vaccine immunogenicity;Work

PROJECT_TITLE: Clonal growth and prediction of monoclonal B-cell lymphocytosis

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: AMHERST

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Multiple sclerosis (MS) is one of the most frequent nontraumatic disabling neurologic disorders, affecting approximately 309 per 100,000 adults in the United States. There is a critical need to routinely image brain oxygen extraction fraction (OEF), a direct biomarker for tissue viability and functional activities, in MS patients for better understanding, diagnosing, and treating MS. The proposed research will develop a noninvasive, widely available imaging method for mapping OEF, which can be routinely used on all 3T magnetic resonance imaging (MRI) scanners to study neurologic disorders, including MS.

PI_NAMEs: CHO, JUNGHUN  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Adult;Affect;Agreement;Biological Markers;Blood;Blood Vessels;Brain;Brain imaging;Brain Neoplasms;cerebral atrophy;Chronic;Clinic;clinic ready;Clinical;Data;data acquisition;Dementia;density;Development;Diagnosis;Disability scale;Disabling;Disease;effective therapy;Elderly;Ensure;Fingerprint;Gases;Hydrocephalus;Image;imaging modality;Impairment;improved;Inflammation;Inhalation;Injections;Iron;Ischemic Stroke;Lesion;longitudinal dataset;Macrophage;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methodology;Methods;Microglia;Microvascular Dysfunction;mitochondrial dysfunction;Modeling;Monitor;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;neglect;Nervous System Disorder;novel;Oxygen;Participant;Patients;Phase;Physiological;Positron-Emission Tomography;Pre-Eclampsia;Predisposition;Prevalence;Prognosis;progressive neurodegeneration;radioligand;Reference Standards;Research;Resolution;routine imaging;Severity of illness;signal processing;Signal Transduction;simulation;Source;Structure;Techniques;Testing;tissue biomarkers;Tissue Extracts;Tissue Viability;Tissues;tool;Tracer;United States;usability;Veins;Venous;venule;water diffusion;white matter

PROJECT_TITLE: MRI-Based Quantitative Mapping of Oxygen Extraction Fraction in MS

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences;Urologic Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project is relevant to public health because it will advance understanding of a progressive form of multiple sclerosis (MS), a debilitating neurological disease that damages the brain and spinal cord. Primary progressive MS patients experience worsening neurologic function and disability from disease onset, and symptoms such as problems with walking and bladder/bowel dysfunction significantly impact quality of life, yet few approved treatments are available, in part because we lack a complete understanding of the pathology underlying progression in the lower spinal cord. This project aims to evaluate the extent of lumbosacral spinal cord pathology and its role in driving clinical disability in primary progressive MS by applying structural, functional, and myelin-sensitive, quantitative MRI methods in this critical anatomy and identifying sensitive and specific imaging biomarkers of progressive disease that address the current gap in evaluating the full extent of spinal cord pathology in MS.

PI_NAMEs: O'GRADY, KRISTIN POOLE (contact)

PROJECT_TERMS: Address;Affect;Age;Anatomy;Atrophic;Automobile Driving;Autonomic Dysfunction;Biological;Biology;Bladder;Bladder Dysfunction;Brain;Brain Injuries;burden of illness;Cauda Equina;Cervical;Cervical spinal cord structure;Chronic;Clinical;cohort;Complement;Conus genus;conus medullaris;Data;Demyelinating Diseases;Demyelinations;Detection;Diffuse;Diffusion Magnetic Resonance Imaging;disability;Disease;Disease Progression;experience;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;healthy volunteer;Height;illness length;Image;imaging biomarker;imaging modality;immunomodulatory therapies;improved;indexing;Inflammatory;innovation;Intestines;Lesion;Lower Extremity;Lumbar spinal cord structure;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measures;Mentored Research Scientist Development Award;Methods;Mission;Monitor;morphometry;Motor;multimodality;Multiple Sclerosis;multiple sclerosis patient;Myelin;National Institute of Neurological Disorders and Stroke;Nerve;Nerve Degeneration;nerve supply;Nervous System Disorder;Nervous System Physiology;Neurogenic Bladder;Neurological disability;novel;Onset of illness;Pathologic;Pathology;Patients;Primary Progressive Multiple Sclerosis;Process;progression marker;Progressive Disease;Public Health;Quality of life;quantitative imaging;Radiology Specialty;Relapsing-Remitting Multiple Sclerosis;Reproducibility;Research;Resistance;Resolution;Rest;Role;Sacral spinal cord structure;Sampling;Self-Help Devices;Sensory;sex;specific biomarkers;Spinal;Spinal Cord;Spinal cord grey matter structure;Spinal Cord Lesions;Spinal nerve root structure;Structure;symptom management;Symptoms;Testing;Therapeutic;Therapy Evaluation;timeline;Tissues;tool;treatment response;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Multimodal, quantitative MRI in the lumbosacral spinal cord in progressive multiple sclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-S (03)]


ADMINISTERING_IC: HD

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: MIAMI

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Understanding the impact of screen media use in early childhood is a major public health priority. Emerging research has suggested associations between child screen media use and child emotional and behavioral problems; however, the nature of these associations is still under debate given mixed findings, unclear mechanisms, and the lack of longitudinal research in this area. Therefore, the proposed research will examine longitudinal and transactional associations between characteristics of family media use and child emotional and behavioral functioning, and investigate caregiver-child interactions, parenting, and caregiver distress as key mechanisms of these associations.

PI_NAMEs: BAGNER, DANIEL MARC;GRIFFITH, SHAYL  (contact)

PROGRAM_OFFICER_NAME: GALLEN, COURTNEY LEIGH

PROJECT_TERMS: 2 year old;3 year old;Address;Age;Age Years;Area;Attention;Automobile Driving;Behavior;Behavioral;Caregiver well-being;Caregivers;Child;Child Behavior;Child Development;Child Rearing;cohort;Complex;contextual factors;Development;digital;digital media;digital technology;Distress;early childhood;early screening;Emotional;Enrollment;Exposure to;externalizing behavior;Family;Family Characteristics;Funding;Growth;Guidelines;Infant;Informal Social Control;Intervention;kindergarten;Link;Longitudinal Studies;Measures;media use;Mediating;Mediator;Mental Health;Modeling;Modernization;National Institute of Child Health and Human Development;Nature;Outcome;parenting intervention;Parents;Pattern;Play;Problem behavior;Public Health;public health priorities;randomized controlled design;randomized trial;Randomized, Controlled Trials;Regulation;Research;Risk;Shapes;skills;Stress;Technology;theories;Time;Transact;trial design

PROJECT_TITLE: Examining Complex Transactional Associations among Family Media Use, Caregiver-Child Interactions, and Behavioral Functioning in At-Risk Young Children

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: MADISON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: More than 50 million people in the U.S. provide care for spinal cord injury patients each year. Here we propose to release anti-inflammatory cytokines locally after spinal cord injury, to reduce inflammation and secondary damage, resulting in an improvement of function below the level of injury. Even a limited amount of functional improvement can greatly increase the independence of spinal cord injury patients and enhance their quality of life.

PI_NAMEs: HANNA, AMGAD S (contact);MURPHY, WILLIAM L.

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Aftercare;Age;Anti-Inflammatory Agents;Attention;Attenuated;Axon;axon growth;axonal degeneration;Binding;Biological;Biological Assay;biological systems;Blood;Caring;Cell Proliferation;Cells;Characteristics;Cicatrix;clinically relevant;Complex;Cues;cytokine;Data;design;Development;dosage;Dose;Drug Delivery Systems;Flow Cytometry;functional improvement;Goals;Growth Factor;Half-Life;Health Care Costs;Healthcare Systems;high risk;Hour;Immune;immune cell infiltrate;improved;In Vitro;in vivo;infection risk;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Interleukin-10;Interleukin-13;Interleukin-4;Lesion;Limb structure;Macrophage;Mechanics;Methods;Minerals;Modeling;Molecular;Motor;motor function improvement;Nerve Degeneration;neural;neurotrophic factor;Neutrophil Infiltration;novel strategies;Outcome;Paralysed;particle;Persons;Phenotype;Population;preservation;Proteins;Quality of life;Rattus;Reaction;receptor;Research;response;Sensory;Signal Transduction;Site;Spinal Cord;Spinal cord injury;Spinal cord injury patients;synergism;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Tissue Engineering;transcriptome sequencing;Trauma;white matter;Work

PROJECT_TITLE: Treating Spinal Cord Injury with Mineral Coated Microparticles Releasing Anti-Inflammatory Cytokines

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Prevention;Serious Mental Illness;Suicide;Suicide Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE We have found that elevated emotional impulsivity (urgency) plays an important role in suicidal ideation and behavior (SIB) in schizophrenia spectrum disorder (SSD) and that activation in those with high vs. low levels of SIB was associated reduced fMRI activation in brain areas related to urgency. We propose to extend this work to another disorder with elevated risk for suicide (major depressive disorder). This cross-diagnostic work will allow us to identify the ideal regions to target using neuroscience-informed therapies, with the aim of reducing NU and ultimately, SIB.

PI_NAMEs: HOPTMAN, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Affect;Affective;Anterior;Area;behavior prediction;Behavior Therapy;Behavioral;Brain;Chronic;cingulate cortex;cognitive control;cognitive testing;cohort;Collaborations;connectome;Data;depressive symptoms;Diagnosis;Diagnostic;Disease;emotion regulation;Emotional;Emotions;Enrollment;Esthesia;examination questions;Feeling suicidal;Functional disorder;Functional Magnetic Resonance Imaging;General Population;Generations;healthy volunteer;high risk;high risk population;Image;Impulsivity;Individual;Interruption;Intervention;Interview;Lateral;Left;Major Depressive Disorder;Measures;Medial;Mediating;medical schools;Medicine;Meditation;Mental disorders;Methods;mortality;MRI Scans;Negative Valence;neural circuit;neuroregulation;Neurosciences;novel therapeutic intervention;Participant;Patients;Persons;Play;Population;positive emotional state;Prefrontal Cortex;Proxy;psychiatric inpatient;Psychoses;Public Health;Questionnaires;Recording of previous events;reducing suicide;response;Rest;Role;Sampling;schizophrenia spectrum disorder;Severities;Site;Stimulus;Structure;suicidal;suicidal act;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Superior temporal gyrus;therapy development;Thick;tractography;Work

PROJECT_TITLE: A Transdiagnostic Study of Emotional Impulsivity in Suicidal Ideation and Behavior

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: BRONX

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Public Health Relevance Statement Cancer therapy increasingly depends on the use of two or more drugs to complement and strengthen each others action. The approved cancer drug Forodesine is highly effective in cancers that are genetically missing a second cancer target called SAMHD1. But most cancers have excess SAMHD1 and there are no approved drugs or clinical trials yet reported for SAMHD1. Transition state analysis, featured here, has a proven record of generating powerful enzymatic inhibitors that have success in clinical trials. SAMHD1 inhibitor development has the potential to open a powerful therapeutic window for leukemia and other cancers.

PI_NAMEs: SCHRAMM, VERN L. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Affinity;analog;Animal Model;anti-cancer;Antineoplastic Agents;Apoptosis;Apoptotic;Binding;Binding Sites;Biochemical;Biological;cancer cell;Cancer cell line;Cancer Center;Cancer Etiology;Cancer Patient;cancer therapy;carcinogenesis;Catalytic Domain;Cell Culture Techniques;Cell Death;Cell Line;Cell model;Cells;Charge;chemical synthesis;Chemicals;Chemistry;Chemotherapy-Oncologic Procedure;Clinical Trials;Collection;combinatorial;Complement;Complex;computational chemistry;conformational conversion;Coupled;Decitabine;deoxyguanosine triphosphate;design;Development;Disease remission;Docking;drug action;drug candidate;Drug Design;drug discovery;drug efficacy;Drug Kinetics;drug testing;efficacy study;Electrostatics;Elements;Enzymes;Excretory function;experimental study;Genomics;Geometry;Growth;Guanosine;HIV-1;Human;Immucillin-H;improved;Induction of Apoptosis;inhibitor;Isotope Labeling;Isotopes;Japan;Kinetics;Laboratories;Lead;leukemia;Libraries;Link;Malignant - descriptor;Malignant Neoplasms;Maps;Marketing;Mediating;Metabolism;Molecular Conformation;Mus;novel;Oral;Outcome;Pathway Analysis;patient derived xenograft model;Patients;Peripheral;Permeability;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Positioning Attribute;Predisposition;prevent;programs;Protein Dynamics;Proteins;pseudotoxoplasmosis syndrome;public health relevance;purine analog;Purine Nucleoside Phosphorylase Inhibitor;Purine-Nucleoside Phosphorylase;quantum chemistry;Reaction;Refractory;Relapse;Reporting;residence;responders and non-responders;response;SAM Domain;screening;Second Primary Cancers;Stable Disease;structural biology;Structure;success;synthetic lethal interaction;T-Cell Lymphoma;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;TP53 gene;Transition Elements;treatment response;tripolyphosphate;tumor xenograft;Underrepresented Minority;Viral Physiology;Xenograft procedure

PROJECT_TITLE: Targeting the PNP - SAMHD1 synthetic-lethal combination in cancer

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Maternal Health;Orthopoxviruses;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Little is known about the impact of MPXV infection on pregnant people or developing fetuses. We will determine the rate and pathways of vertical transmission, define the association of mpox disease severity and adverse pregnancy outcomes, and determine whether antiviral treatment can improve pregnancy outcomes in a translational macaque model. This will fill critical knowledge gaps in the clinical care of pregnant persons that cannot be learned from epidemiological studies alone.

PI_NAMEs: MOHR, EMMA L (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;adverse pregnancy outcome;Anti-viral Agents;Biological Assay;Biological Models;Blood;Case Study;Central Africa;clinical care;Clinical Management;Clinical Trials;Data;Disease;Disease Outbreaks;Disease Outcome;early pregnancy;Early treatment;Emerging Communicable Diseases;epidemiology study;fetal;Fetal Development;Fetal Growth;Fetus;First Pregnancy Trimester;Future;global health;Health;Human;Immune response;improved;Infant;Infection;Knowledge;Learning;Macaca;Macaca mulatta;Maternal antibody;Maternal-Fetal Exchange;Modeling;Monkeypox;Monkeypox virus;Mothers;off-label use;Outcome;Pathway interactions;Persons;Placenta;pre-clinical;Pregnancy;Pregnancy Outcome;pregnant;Pregnant Women;prenatal;Risk;Severity of illness;skin lesion;Structure;Testing;transmission process;United States;Vertical Transmission;Viral;viral DNA;Virus;Virus Diseases;ZIKV infection

PROJECT_TITLE: Vertical transmission, pregnancy outcomes and treatment of Mpox virus infection in a translational pregnant macaque model

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: FOXL1 positive telocytes in intestinal development and homeostasis Narrative Diseases of the gastrointestinal tract including inflammatory bowel disease and colon cancer represent serious health problems in the United States. Self-renewal of the gut lining throughout life is dependent on specialized niche cells that support the division of gut stem cells. Here, we will identify genes and pathways that control niche cell biology that might be targeted in the future for better treatment of diseases of the alimentary tract.

PI_NAMEs: KAESTNER, KLAUS H (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;absorption;Adult;adult stem cell;Alleles;analog;Bacterial Artificial Chromosomes;Biological Assay;Biology;Bromodeoxyuridine;Cell Differentiation process;Cell Nucleus;cell type;Cells;Cellular biology;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Carcinoma;Defect;Development;Digestive System Disorders;Disease;DNA Binding;Embryo;Epithelium;Excision;Factor Analysis;Failure;Fasting;feeding;fetal;Fetal Development;Fibroblasts;FOXF1 gene;FOXL1 gene;Future;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Gene Expression Regulation;gene function;Gene Targeting;Genes;GLP-2;GLP-2R;Growth;Growth Factor;Health;Histology;Homeostasis;Hormones;IGF1 gene;Image;Impairment;Individual;Inflammatory Bowel Diseases;innovation;intestinal crypt;intestinal epithelium;intestinal villi;Intestines;Knockout Mice;L Cells;Life;Light;Link;Loss of Heterozygosity;LoxP-flanked allele;Mediating;Mesenchymal;Mesenchyme;Mitogens;Molecular;Mucous Membrane;multiple omics;Mus;mutant;Mutant Strains Mice;novel;Pathway interactions;Phenotype;planar cell polarity;Play;Pregnancy;Process;Production;progenitor;Proliferating;Protein Analysis;protein biomarkers;protein function;receptor;Receptor Signaling;response;Role;Scanning Electron Microscopy;self-renewal;Seminal;Shapes;Signal Transduction;single-cell RNA sequencing;Small Intestines;Sorting;Stains;stem cell biology;stem cell niche;stem cell population;stem cells;Stromal Cells;Supporting Cell;System;Testing;Tissues;tool;Transcript;transcription factor;transcriptome sequencing;Transgenic Organisms;United States;Villus;Winged Helix;WNT Signaling Pathway

PROJECT_TITLE: FOXL1 positive telocytes in intestinal development and homeostsis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


PHR: Despite the success of hemodialysis in supporting patients with kidney failure, patients who rely on dialysis remain extremely ill. It is thought that dialysis only removes some of the toxins that the kidney removes. In this project, we examine whether changing the shape of the dialyzer can better copy the toxin removal of a healthy kidney and reduce the tendency of these patients to form life-threatening blood clots.

PI_NAMEs: FISSELL, WILLIAM H (contact);ROY, SHUVO

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Adverse effects;Affect;Albumins;American;Anemia;Animal Model;Anticoagulation;Area;Bacteria;Behavior;Binding;Binding Proteins;Blood;Blood coagulation;Blood flow;Blood Platelets;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chronic;Coagulation Process;Cognition Disorders;Computer Models;Coronary Thrombosis;Cresol;Data;Defect;Dependence;design;Dialysis patients;Dialysis procedure;Diameter;Diffuse;disability;Distant;Drops;Embolism;Endocrine System Diseases;Endothelium;Excision;experience;Exposure to;Fermentation;Fiber;Geometry;Guidelines;Health;Hemodialysis;Hemolysis;Heparin;Hospitalization;Immune;Immune System Diseases;Impairment;In Vitro;Incidence;Indican;Inflammation;Intestines;Kidney;Kidney Failure;Kinetics;Kynurenic Acid;Length;Libraries;Life;Liquid substance;Lung;Malnutrition;Maps;Measures;Membrane;Modeling;mortality;Myocardial Infarction;Names;neutrophil;novel;Organ Donor;Pathologic;Patients;Phase;Physiological;Plasma Albumin;Platelet Activation;pressure;prevent;Procedures;Pulmonary Embolism;Renal dialysis;residence;Residual state;response;Risk;Role;Sepsis;Shapes;shear stress;simulation;Site;solute;Stroke;Structure;success;Sulfate;Surface;Syndrome;Testing;Thromboplastin;Thrombosis;Thrombus;Time;Toxin;Transplantation;Trauma;Urea;Uremia;Waste Products;wasting

PROJECT_TITLE: Beyond Urea Kinetics: Balancing Tradeoffs in Dialyzer Design for the Next 50 Years

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This proposal seeks to elucidate the role of Th1 cells in multiple system atrophy (MSA), a debilitating, fast- progressing neurodegenerative and demyelination movement disorder with no current treatment options. When IFNɣ was knocked down there was a significant reduction in overall neuroinflammation, and demyelination; however, the IFNɣ producing cell that is responsible for MSA pathology is unknown. Therefore, this proposal identifies if Th1 (CD4+ T cells that produce IFNɣ) are required for MSA pathology within the Olig001 mouse model.

PI_NAMEs: CORBIN-STEIN, NICOLE  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: adaptive immune response;Address;adeno-associated viral vector;age acceleration;Aging;Agreement;alpha synuclein;Alzheimer's Disease;Antigen Presentation;Antigen-Presenting Cells;Attenuated;Autopsy;Behavior;Binding;Bioinformatics;CD3 Antigens;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Aging;Cells;cerebral atrophy;Corpus Callosum;Corpus striatum structure;cytokine;Cytoplasmic Inclusion;Data;Defect;Demyelinating Diseases;Demyelinations;Disabling;Disease;Disease Progression;Dorsal;Fellowship;Flow Cytometry;Genetic;Goals;HLA Antigens;HLA-DR Antigens;Immune;immune cell infiltrate;Immunohistochemistry;Infiltration;Inflammation;Inflammatory;Innate Immune Response;Interferon Type II;knock-down;Knock-out;Knowledge;Lateral;Lead;Lesion;Life;Macrophage;Mediating;Mentors;Microglia;Modeling;Motor;motor behavior;motor deficit;mouse model;Movement Disorders;Multiple Sclerosis;Multiple System Atrophy;Mus;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;neuroimmunology;neuroinflammation;neuron loss;neutralizing antibody;Oligodendroglia;Onset of illness;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Positioning Attribute;Postdoctoral Fellow;prevent;Process;Production;putamen;receptor;Research Personnel;response;Rodent;Rodent Model;Role;senescence;Specificity;Substantia nigra structure;synucleinopathy;T cell response;T-Lymphocyte;Th1 Cells;Tissues;transcription factor;transcriptome sequencing;Tropism;Viral Vector;Work

PROJECT_TITLE: Interferon-gamma mediates neuroinflammation, demyelination, and neurodegeneration in a mouse model of multiple system atrophy (MSA)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE State of the art biomaterials will be used to create an advanced microscale model of the human colon to study how colon cancer develops and grows.

PI_NAMEs: ALLBRITTON, NANCY L. (contact);DEFOREST, COLE A;GRADY, WILLIAM MALLORY

PROJECT_TERMS: 3-Dimensional;adenoma;Animal Model;Animals;Apoptosis;Architecture;Automobile Driving;Behavior;Biochemical;Biocompatible Materials;Biological Models;Biomedical Engineering;biophysical properties;Biophysics;Caco-2 Cells;Cancer Etiology;cancer initiation;cancer type;Cell Physiology;Cell Respiration;Cells;Cessation of life;Characteristics;Chemicals;chemotherapy;Colon;Colon Carcinoma;colon tumorigenesis;colonic crypt;Colonic Neoplasms;Colony-forming units;Colorectal Cancer;Complex;Culture Techniques;Cultured Tumor Cells;Data Set;Development;Devices;Disease;DNA Sequence Alteration;Environment;Epithelial Cells;Epithelium;Ethics;Evolution;experimental study;Extracellular Matrix;fabrication;Family suidae;Fibroblasts;Fluorouracil;G-Protein-Coupled Receptors;Gases;Genetic;Geography;Goals;Growth Factor;Health;Hepatic;Hepatocyte;Human;hydrogel scaffold;Hydrogels;Image;improved;In Vitro;in vitro Model;in vivo;Incidence;International;Intestines;Investigation;Lesion by Stage;Leucine-Rich Repeat;LGR5 gene;Light;Malignant Neoplasms;materials science;matrigel;Measures;Metastatic breast cancer;Metastatic Neoplasm to the Liver;Microfluidic Microchips;microphysiology system;migration;Modeling;monolayer;Mus;mutant;neoplastic cell;Normal Cell;novel;Nuclear Translocation;OLFM4 gene;Oncogenic;Oncology;Optics;Organ Model;Organoids;Oxidative Phosphorylation;Oxygen;Physiological;Play;polyacrylamide hydrogels;Polyps;Population;Predisposition;prevent;Process;Proliferating;Property;Proxy;Research Personnel;response;Role;scaffold;Science;Small Intestines;spheroids;stem cell biology;stem cell biomarkers;stem cell differentiation;stem cells;subcutaneous;System;Technology;Testing;Therapeutic;three-dimensional modeling;Time;tissue culture;Tissues;tool;trait;tumor;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;virtual;Work;Xenograft Model

PROJECT_TITLE: A 4D-tunable hydrogel for the study of the impact of the tumor microenvironment on the development of colorectal cancer

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Chemical signals produced by males hasten female sexual maturation in different species, including mammals. We developed a powerful paradigm to study the neuronal circuits and signaling pathways underlying this phenomenon. We expect to discover mechanisms that coordinate development with appropriate behavioral programs, thus informing our understanding of pathological conditions caused by defects in developmental timing.

PI_NAMEs: RUVINSKY, ILYA  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Acceleration;Adult;Advocate;Afferent Neurons;Behavior;Behavior monitoring;Behavioral;Biological Models;Caenorhabditis elegans;Cell Lineage;Cells;Chemicals;Coupled;Coupling;Custom;Defect;Development;Developmental Biology;Developmental Process;Disease;early experience;early onset;Eating;Ensure;Environment;Event;Excretory function;experimental study;Exposure to;Female;flexibility;Food;Foundations;genetic manipulation;Goals;Growth;Growth and Development function;Hermaphroditism;imaging system;Individual;innovation;Insulin;inter-individual variation;machine vision;male;Mammals;Mediating;member;Modeling;Monitor;Nature;Nervous System;neuronal circuitry;Neurons;neurotransmission;Organism;Partner in relationship;Pathologic;Pathway interactions;Pheromone;Process;programs;receptor;Regulation;Reporting;Research;Resolution;Resources;response;Role;sex;sexual identity;Sexual Maturation;sexual role;Signal Pathway;Signal Transduction;Signaling Molecule;small molecule;social;Social Interaction;Speed;System;Testing;tool;Variant;Work

PROJECT_TITLE: Signals and circuits that regulate developmental timing

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Public Health Relevance Statement: Sudden cardiac arrest is a major public health issue in the United States. The purpose of this study is to determine the role of CD73 expressing lymphocytes in the protection against excessive inflammation and secondary heart and brain tissue damage after initial global ischemia and reperfusion injury. The anticipated data may lead to the development of novel immunotherapies to cure patients with cardiac arrest.

PI_NAMEs: RYZHOV, SERGEY  (contact);SEDER, DAVID B.

PROGRAM_OFFICER_NAME: SOPKO, GEORGE

PROJECT_TERMS: 5'-Nucleotidase;Ablation;Acute;adaptive immunity;Adenosine;Adhesions;Adoptive Cell Transfers;Adoptive Transfer;Anti-Inflammatory Agents;Binding;Biopsy;Brain;Brain Injuries;brain tissue;Cardiac;Cardiopulmonary Resuscitation;CD3 Antigens;CD4 Positive T Lymphocytes;Cell Adhesion Molecules;Cells;Cerebrospinal Fluid;Circulation;cohort;Complex;Critical Illness;Data;Development;early onset;Endothelial Cells;Endothelium;Enzymes;Family;Generations;Genes;Genetic;Goals;healing;Heart;Heart Arrest;Heart Injuries;Hour;Human;human data;Immune;immune activation;Immune response;Immunocompromised Host;immunomodulatory therapies;immunoregulation;Immunotherapy;improved outcome;In Vitro;in vivo;Induced Heart Arrest;Infection prevention;Inflammation;Inflammatory;Inflammatory Response;Intercellular adhesion molecule 1;intravenous injection;ischemic injury;Knockout Mice;Knowledge;Lymphocyte;Macrophage;Measures;Mediating;migration;Molecular;monocyte;mortality;mouse model;Mus;Myeloid Cells;Natural Immunity;nectin;nectin-3;Neurological outcome;neurological recovery;neutralizing antibody;novel;Operative Surgical Procedures;Outcome;Patients;Peripheral;pharmacologic;Phenotype;Plasma;Population;Production;Property;Proteins;Proteomics;Public Health;public health relevance;Purine Nucleosides;Purinergic P1 Receptors;Regulation;Reperfusion Injury;response;Role;Sampling;Signal Transduction;Survival Rate;Survivors;systemic inflammatory response;T-Lymphocyte;Testing;Therapeutic;Time;Tissues;Transplantation;United States;Variant

PROJECT_TITLE: Protective adaptive immune mechanisms after cardiac arrest

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: NARRATIVE For the first time, the US Food and Drug Administration has authorized two brands of smokeless tobacco to make advertising claims that their products pose lower health risks to users than cigarette smoking. This study will use complementary and innovative research activities (including an online survey and experiment, an experimental auction, and an in-person product use lab study) to explore consumers’ exposure and reactions to authorized smokeless tobacco modified risk claims, and whether these claims influence smokeless tobacco demand and sensory evaluations.

PI_NAMEs: O'CONNOR, RICHARD J (contact);WACKOWSKI, OLIVIA

PROGRAM_OFFICER_NAME: KAUFMAN, ANNETTE R

PROJECT_TERMS: Adult;Advertising;aged;Authorization documentation;Awareness;Belief;cancer risk;cancer type;Characteristics;Chronic Bronchitis;Cigarette;cigarette smoke;cigarette smoking;cigarette user;Color;combustible cigarette;Complement;consumer behavior;consumer product;Descriptor;Disease;Elements;Evaluation;Expectancy;experience;experimental study;Exposure to;Future;Harm Reduction;Health;Heart Diseases;Image;Imagery;improved;Individual;innovation;Laboratories;Legal;Light;Lung;male;malignant mouth neoplasm;Malignant neoplasm of lung;Marketing;Modified Risk Tobacco Product;Nicotine;Participant;Pathway interactions;Perception;Persons;Pharmaceutical Preparations;Positioning Attribute;Pulmonary Emphysema;Reaction;Research;Research Activity;Research Methodology;response;Risk;Risk Reduction;Rural;Sampling;satisfaction;Sensory;Series;side effect;Smokeless;Smokeless Tobacco;Smoker;Smoking;snus;Sports;Stroke;Surveys;Taste Perception;Time;tobacco advertising;Tobacco Industry;tobacco products;Tobacco use;United States Food and Drug Administration;Withdrawal

PROJECT_TITLE: Assessment of consumer response to smokeless tobacco modified risk marketing orders

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Bipolar disorder is a lifelong illness with a significant and chronic disease burden made worse by severe and episodic disruptions in the regulatory control of emotion (emotion regulation). The development of rapid-acting treatment options that improve emotion regulation for individuals with bipolar disorder are needed to help achieve and sustain remission and improve long-term functioning. This study will use a rapid and robust form of neuromodulation (transcranial magnetic stimulation) to investigate the mechanisms related to impaired emotion regulation in bipolar disorder and the potential for this approach to improve emotion regulation, as an important first step towards validating this approach as a treatment option for individuals with bipolar disorder.

PI_NAMEs: ELLARD, KRISTEN K (contact)

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: Acceleration;Affect;alternative treatment;Amygdaloid structure;Anterior;Awareness;Behavior;Behavioral;Bipolar Disorder;Brain;burden of chronic illness;Characteristics;Chronic;Clinical;Computers;Data;Depressed mood;depressed patient;Development;Disease remission;Dorsal;Dose;emotion dysregulation;emotion regulation;Emotions;executive function;experience;FDA approved;Feeling suicidal;Functional Magnetic Resonance Imaging;Future;Impairment;improved;Impulsivity;indexing;Individual;Inferior;Insula of Reil;Length;Lobule;Manic;Measures;Mental Depression;Moods;neural circuit;neuromechanism;Neuronal Plasticity;neuroregulation;Outcome;Parietal;Patients;Performance;Physiologic pulse;Population;Prefrontal Cortex;Productivity;Randomized;Reaction Time;response;Rest;Rewards;Sampling;Scanning;Structure;suicidal behavior;Symptoms;Testing;therapy development;Time;tool;Transcranial magnetic stimulation;Translations;Validation;Work

PROJECT_TITLE: Targeting Emotion Regulation in Bipolar Disorder with Intermittent Theta Burst Stimulation: A Mechanistic Study


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Palliative Care

ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Although adults with blood cancers experience substantial symptom burden that worsens near the end of life, fewer than 25% enroll in hospice. Lack of access to palliative blood transfusions to manage symptoms of fatigue, dyspnea, and bleeding is a critical barrier to hospice use for this population; yet, there is a striking lack of research testing interventions that directly address this problem. This proposal seeks to test the efficacy of access to a novel model of care delivery that combines palliative home transfusions with core elements of hospice care, with the goal of improving hospice enrollment and end-of-life care for patients with blood cancers.

PI_NAMEs: ODEJIDE, OREOFE OLUKEMI (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Address;Admission activity;Adult;Anemia;blood product;Blood Transfusion;Cancer Center;Cancer Patient;care delivery;caregiver bereavement;Caregivers;Caring;Cessation of life;Chaplain;chemotherapy;Cluster randomized trial;Data;Dyspnea;efficacy testing;Electronic Health Record;Elements;Eligibility Determination;end of life;end of life care;Enrollment;Expenditure;experience;Fatigue;Goals;Grief reaction;Health Expenditures;Health Surveys;Healthcare;Hematologic Neoplasms;Hematology;Hematopoietic Neoplasms;Hemorrhage;Home;Home Health Aides;Hospice Care;hospice environment;Hospice Programs;hospice utilization;Hospitalization;Hospitals;improved;innovation;Intensive Care Units;Intervention;Laboratories;Length;Life;Life Expectancy;Malignant Neoplasms;Massachusetts;Medical;Modeling;Monitor;Moods;New England;novel;Nurses;Oncologist;oncology program;Outcome;Pain;palliating symptoms;palliative;participant enrollment;Pathway interactions;Patient Care;patient population;Patients;Persons;Policies;Population;preservation;primary outcome;quality of death;Quality of life;Randomized;Refractory anemias;Reporting;Research;response;Risk Reduction;secondary outcome;Service delivery model;Services;Shortness of Breath;Social Workers;Standardization;Structure;Symptom Burden;symptom management;Symptoms;Testing;Thrombocytopenia;Training;Transfusion;treatment as usual;United States;Visiting Nurse

PROJECT_TITLE: HEME-Hospice: An Intervention to improve Hospice Use for Patients with Hematologic Malignancies

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: SURGERY

PHR: Project Narrative Voice disorders affect approximately 7.5 million Americans. However, there are not enough individuals with the expertise and training to perform high-quality basic, translational, and clinical research that will result in successful treatments for these disorders. The University of Wisconsin-Madison Voice Research Training Program is training graduate students as well as individuals with PhDs and MDs to lead successful academic careers with a focus on research in voice.

PI_NAMEs: THIBEAULT, SUSAN LYNN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: University of Wisconsin Voice Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (11)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Narrative Osteosarcoma, a malignant primary tumor of bone, is a devastating disease with dismal outcomes for both adult and pediatric patients. There has been a significant lack of improvement in survival over the past three decades, and there remains high complication rates for limb salvage approaches. The goal of this project is to develop a novel image-guided histotripsy system for the complete, uniform, and non-invasive treatment of heterogenous osteosarcoma in adults and children.

PI_NAMEs: VLAISAVLJEVICH, ELI  (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Acoustics;Adult;Amputation;Anatomy;Animal Model;Animals;anti-tumor immune response;Biological;Biology;bone;Bone neoplasms;Bone Tissue;cancer care;Cancer Center;Canis familiaris;Characteristics;Child;clinical translation;Common Neoplasm;Complication;Connective Tissue;Data;design;design and construction;Devices;Disease;Ensure;Exhibits;Focused Ultrasound;Follow-Up Studies;Goals;Human;Image;image guided;improved;improved outcome;in vivo;in vivo evaluation;Individual;individualized medicine;invention;Laboratories;Limb Salvage;Longterm Follow-up;Lytic;Malignant - descriptor;Malignant Bone Neoplasm;mechanical properties;Mechanics;Methods;Michigan;Mobility decline;Monitor;Morbidity - disease rate;Nature;NCI Center for Cancer Research;Nerve;neurovascular;Nonmetastatic;novel;Obstruction;Operative Surgical Procedures;Osteosarcoma;Outcome;Patients;pediatric patients;Phase;Phenotype;preservation;primary bone cancer;Proliferating;prototype;Resected;Robotics;Safety;safety and feasibility;safety testing;Skeleton;Soft Tissue Neoplasms;Structure;Survival Rate;System;Techniques;Time;Tissues;Transducers;Translations;transmission process;treatment optimization;treatment strategy;tumor;tumor ablation;tumor heterogeneity;Ultrasonic Therapy;Ultrasonography;Universities;Virginia

PROJECT_TITLE: Image-guided Histotripsy System for Complete, Uniform, and Non-Invasive Ablation of Heterogeneous Osteosarcoma Tumors

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Prevention;Women's Health Research

ORG_CITY: STONY BROOK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: The goal of this proposed work is to develop and clinically-translate a novel dual-layer flat-panel detector (DLFPD) for breast cancer detection. It acquires two x-ray images simultaneously at different energies, thereby allowing additional contrast information for improved breast cancer screening and diagnosis at low cost.

PI_NAMEs: ZHAO, WEI  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Area;Back;Breast;Breast Cancer Detection;Breast Cancer Treatment;breast imaging;Breast Magnetic Resonance Imaging;Canada;Charge;Clinical;clinical translation;Clinical Trials;Collaborations;Commercial grade;cone-beam computed tomography;contrast enhanced;Contrast Media;cost;design;detector;Development;Diagnosis;digital;Digital Breast Tomosynthesis;Digital Mammography;Evaluation;Flying body movement;Goals;Image;image processing;imaging study;Imaging Techniques;improved;improved outcome;Industrialization;industry partner;Mammography;Methods;Monitor;Morphologic artifacts;Motion;novel;Outcome;Patient imaging;Patients;Performance;photon-counting detector;prototype;Recording of previous events;research clinical testing;Resolution;Roentgen Rays;Scanning;Sensitivity and Specificity;simulation;Slice;spectral energy;spectrograph;Spottings;System;Techniques;Technology;tool;Translating;Tube;Universities;virtual;virtual imaging;Work;X-Ray Medical Imaging

PROJECT_TITLE: A direct-indirect dual-layer flat-panel detector for breast cancer detection

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cancer;Complementary and Integrative Health;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: FAIRFAX

ORG_NAME: SOCIETY FOR PREVENTION RESEARCH, INC.

PHR: Project Narrative The Society for Prevention Research’s Annual Meetings bring together scientists from across the country to present the latest scientific discoveries in prevention science. The impact and translation of these discoveries into practice leads to improvements in the nation’s health. The Annual Meetings also support and promote the development and training of the next generation of prevention science leaders, including underrepresented minorities.

PI_NAMEs: PRADO, GUILLERMO  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: addiction;Address;Adopted;alcohol behavior;Alcohol consumption;Alcohols;Area;attributable mortality;Behavior;behavior change;Behavioral;behavioral health;career;Caring;Cause of Death;Cessation of life;Chronic Disease;Communication;Country;Data Science;Dedications;Development;Diabetes Mellitus;Dimensions;Discipline;Disease;Disparity;disparity reduction;dissemination science;Drug usage;effectiveness research;efficacious intervention;efficacy research;Ensure;Epidemiology;Ethnic Origin;Etiology;Event;evidence base;experience;Fertilization;Firearms;Fostering;Funding;Gender;Goals;Growth;Health;Health Disparities Research;health disparity;Health Promotion;Healthcare;Heart Diseases;Heavy Drinking;Heterosexuals;illicit drug use;implementation science;improved;Incidence;innovation;Intervention;Investments;Knowledge;leadership development;Life Cycle Stages;Life Expectancy;life span;Longitudinal Studies;Malignant Neoplasms;meetings;Mental Health;Mentors;Methodology;Methods;minority investigator;Morbidity - disease rate;mortality;multidisciplinary;National Center for Complementary and Integrative Health;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;next generation;Outcome;overdose death;physical conditioning;physical inactivity;Play;Policies;Policy Maker;Population;practice setting;prescription opioid;Prevalence;prevent;Prevention;Prevention program;Prevention Research;Prevention strategy;Prevention trial;preventive intervention;Problem behavior;Public Health;Race;Request for Applications;Research;Research Personnel;Role;Rural;Science;Scientist;Sex Behavior;Sex Orientation;sexual minority youth;Social Environment;social media;Societies;Strategic Planning;synergism;theories;Time;Tobacco use;tool;Training;Translating;Translations;trial design;Underrepresented Minority;Unhealthy Diet;United States National Institutes of Health;Vehicle crash;virtual;Youth

PROJECT_TITLE: Society for Prevention Research Annual Meetings, 2022 - 2026

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Brain Disorders;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This program will leverage the Long-term Impact of Infection with Novel Coronavirus cohort (LIINC; NCT04362150) to determine the underlying biological mechanisms driving neurologic post-acute sequelae of SARS-CoV-2 infection (neuro-PASC). Our central hypothesis is that persistence of SARS-CoV-2 spike protein in the post-acute phase drives ongoing dysregulation of fibrinogen pathways resulting in microclotting and reduced cerebral blood flow which together manifest as neuro-PASC symptoms. To test this model, we will (1) measure plasma SARS-CoV-2 antigen persistence, activity of fibrinogen pathways, and levels of inflammatory biomarkers using previously stored longitudinal biospecimens ranging from 5 days to 4 years post-COVID; (2) apply these methods to prospectively collected biospecimens (blood, cerebrospinal fluid, gut tissue) and clinical data (neurocognitive testing performance, multimodal magnetic resonance imaging); and (3) measure virus persistence, clotting and inflammation in specimens collected as part of a clinical trial of an anti-SARS-CoV-2 monoclonal antibody (AER002; NCT05877508).

PI_NAMEs: PELUSO, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: SAWAKI-ADAMS, LUMY

PROJECT_TERMS: 2019-nCoV;Acute;Affect;Antigens;arterial spin labeling;Atrophic;Automobile Driving;Axon;Binding;Biological;Biological Markers;Biological Specimen Banks;biomarker identification;Biopsy;Blood;Blood Coagulation Disorders;Blood Vessels;blood-brain barrier disruption;Body System;Brain;Cerebrospinal Fluid;Cerebrovascular Circulation;Clinical;Clinical Data;Clinical Trials;Coagulation Process;cohort;Coronavirus;COVID-19;Cox Proportional Hazards Models;Cross-Sectional Studies;cytokine;Data;Deposition;Diagnosis;Diffusion Magnetic Resonance Imaging;Early identification;Emerging Technologies;Enrollment;Fibrin;Fibrinogen;Functional disorder;Functional impairment;Funding;glial activation;gray matter;Headache;Health;Image;Immune System Diseases;Impaired cognition;improved;Individual;Infection;Inflammation;Inflammatory;Infrastructure;Laboratories;Link;Longitudinal Studies;Longterm Follow-up;Macrophage Activation;Magnetic Resonance Imaging;Measures;Mediation;Mediator;Methods;Modeling;Monoclonal Antibodies;Morphology;multimodality;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neuroinflammation;Neurologic;neurologic sequelae of COVID-19;Neurologic Symptoms;Neurons;neuropathology;Neuropathy;novel coronavirus;Outcome;Outpatients;Paper;Parents;Pathology;Pathway interactions;Performance;performance tests;Persons;Phase;Pilot Projects;Plasma;polymerization;Polymers;Post-Acute Sequelae of SARS-CoV-2 Infection;programs;prospective;Prospective Studies;Proteins;proteomic signature;Publishing;randomized trial;reduce symptoms;Reporting;repository;Research Infrastructure;Research Personnel;RNA;Role;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 spike protein;single molecule;Specimen;Spinal Puncture;Susceptibility Gene;symptomatology;Symptoms;Testing;Tissues;tool;United States National Institutes of Health;Viral;Virus;white matter

PROJECT_TITLE: Evaluating SARS-CoV-2 spike antigen-induced coagulopathy and neuroinflammation as mechanistic drivers of neurologic PASC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: PROJECT NARRATIVE Childhood obesity affects 17 percent of children and yet child obesity treatment may be less effective for those with social risk factors. This project will learn whether adding a community health worker to a child obesity treatment program can improve outcomes in families with social risk factors. This project will also learn more about the important factors that explain why some families do not benefit as much as others so we can improve the interventions.

PI_NAMEs: LAROCHE, HELENA HILLMAN (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: 12 year old;Accelerometer;acceptability and feasibility;Address;Affect;African American;behavioral economics;Body mass index;Cardiovascular system;Child;Child Health;Childhood;Clinical Trials;Cognitive;cognitive load;Communities;Community Health Aides;Community Workers;comparative efficacy;Complex;Data;Diabetes Mellitus;Diet;Dietary intake;Disease;Education;efficacy evaluation;Emotional;Enrollment;ethnic minority population;Family;Fatty acid glycerol esters;Feasibility Studies;feasibility testing;flexibility;Food;fruits and vegetables;Future;Goals;Health;health equity;Healthcare;Hour;Housing;implementation outcomes;improved;improved outcome;innovation;insight;Intervention;Interview;Learning;Learning Difficulty;marginalization;marginalized community;Measures;Mediator;Medicaid;Mental Health;Mission;moderate-to-vigorous physical activity;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Obesity;obesity in children;obesity treatment;Occupations;Outcome;Outcome Measure;Overweight;parental role;Parents;Participant;Persons;Population;Poverty;Preparation;Process;Provider;Psyche structure;Public Health;Questionnaires;racial minority population;Randomized;recruit;Research;Resources;Risk Factors;satisfaction;Short-Term Memory;social;social health determinants;standard of care;sugar;sweetened beverage;Testing;Time;Training;Transportation;treatment comparison;Treatment Effectiveness;Treatment Efficacy;Treatment outcome;treatment program;trial comparing;United States Preventative Services Task Force;virtual delivery;Visit;Weight;Weight Gain;Work

PROJECT_TITLE: Addressing social determinants of health in child obesity treatment using community health workers: the role of parental bandwidth in treatment effectiveness - feasibility study for full - scale RCT

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Contraception/Reproduction;Estrogen;Infertility;Neurosciences;Polycystic Ovary Syndrome (PCOS);Women's Health Research

ORG_CITY: KENT

ORG_DEPT: BIOLOGY

ORG_NAME: KENT STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Polycystic ovary syndrome (PCOS) affects up to 13% of women of reproductive age globally. The purpose of this study is to identify key central neuronal circuits that control fertility and determine whether disruptions in these circuits play a role in the development of PCOS. Importantly, identifying and understanding central defects in PCOS is crucial to establish effective treatments and preventative measures for patients with the syndrome.

PI_NAMEs: MOORE, ALEISHA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Affect;Age;Amenorrhea;Androgens;Animal Model;antagonist;Back;Brain;Calcium;Cells;Chronic;Clinical Research;Contraceptive methods;Defect;Development;Diagnosis;diagnostic criteria;Dynorphins;effective therapy;Estradiol;Exhibits;Feedback;Female;Female infertility;folliculogenesis;Foundations;Frequencies;Functional disorder;Generations;Genetic;GNRH1 gene;Gonadotropin Hormone Releasing Hormone;Hormone secretion;Hyperandrogenism;Hypothalamic structure;Impairment;Implant;improved;in vivo;in vivo calcium imaging;Individual;Infertility;KISS1 gene;Location;Luteinizing Hormone;Mediating;Menstrual cycle;Morphology;mouse model;Mus;nerve supply;Neurokinin B;Neuromedin K Receptor;neuronal circuitry;Neurons;Neurosecretory Systems;Oligonucleotides;optogenetics;Ovarian;Ovarian Cycles;ovarian dysfunction;Ovarian Steroid Hormone;Ovariectomy;Ovary;Patients;Peptide Receptor;Peptides;Pharmacologic Substance;Pharmacological Treatment;Phenotype;Physiologic pulse;Pituitary Gland;Play;Polycystic Ovary Syndrome;Population;prenatal;Presynaptic Terminals;Preventive measure;Production;Progesterone;Proxy;Rabies;receptor expression;reduce symptoms;Regulation;reproductive;Research;response;Role;steroid hormone;steroid hormone receptor;Symptoms;Synapses;Syndrome;Testing;Testosterone;therapy development;trait;Visualization;Woman;Work

PROJECT_TITLE: The Role of Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in an animal model of polycystic ovary syndrome

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Our community engagement studies have shown that integrating 3 strengths-based intervention components, each with consistent evidence of effectiveness when studied individually in other clinical conditions (transitional care management, problem-solving rehabilitation, and caregiver support), could address unmet care needs of critical illness survivors and their caregivers when integrated. This proposal will conduct a randomized control trial to establish efficacy of the integrated intervention, Post-Intensive Care: Transitional care, Rehabilitation, and Family Support (PIC-TRFS), on survivor and caregiver outcomes including quality of life, function, survival, trauma symptoms, and healthcare utilization. Success would support PIC-TRFS as high-quality, affordable care via a scalable model of integrated service delivery that should be examined for effectiveness through broader implementation.

PI_NAMEs: SCHEUNEMANN, LESLIE PAGE (contact)

PROGRAM_OFFICER_NAME: PARDASANEY, POONAM

PROJECT_TITLE: PIC-TRFS: A Randomized Trial of a Multicomponent Intervention for ICU Survivors and Caregivers

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Lymphatic Research;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative This project seeks to develop drugs for treating various aspects of RASopathies, genetic disorders altering a fundamental biological process called RAS signaling. To do this, the investigators will use two approaches, one relying on an existing drug developed for cancer treatment and several chemically related ones, and the other being the development of a totally new class of drugs. For both, emphasis will be on understanding how these drugs work to overcome the problems associated with RASopathies using fruit fly, human cell and mouse models of disease.

PI_NAMEs: CAGAN, ROSS LEIGH;GELB, BRUCE D (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Affect;Alleles;analog;Azides;Binding;Biological Process;Biology;Bioluminescence;Biotin;Blood;Brain;cancer therapy;Cardiac Myocytes;Case Study;Cell model;Cells;Chemical Evolution;Chemicals;craniofacial;CRISPR interference;Data;Derivation procedure;Development;Disease;disease model;Drosophila genus;drug development;Energy Transfer;fly;gain of function;Genes;Genetic;genetic approach;Genetic Diseases;Goals;Growth;Head;Heart;human induced pluripotent stem cells;human model;Hypertrophic Cardiomyopathy;Hypertrophy;improved;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inhibitor;insight;knock-down;Lead;Lymphatic;lymphatic malformations;Malignant Neoplasms;Mass Spectrum Analysis;Medical;MEKs;Microtubules;mimetics;Mitogen-Activated Protein Kinases;Modeling;mouse model;mutant;nanoluciferase;Nature;novel;novel drug class;novel strategies;novel therapeutics;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;PIK3CG gene;Proteins;Proteome;Proteomics;Publishing;RAF1 gene;RAS inhibition;Research;Research Personnel;screening;Screening for cancer;side effect;Signal Transduction;small molecule libraries;Solubility;stem cell model;Testing;Therapeutic;therapeutic target;therapy development;trait;Transgenic Organisms;Work

PROJECT_TITLE: Therapy Development for Genetic Disorders of the RAS/MAPK Pathway

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Asthma;Lung

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE  Bronchodilator drugs targeting beta-adrenergic receptors on airways have been used as rescue and preventive medications for asthma. However, this class of drugs has come under scrutiny recently due to their ineffectiveness in controlling asthma symptoms, and due to multiple side effects including asthma-associated death. Studies proposed in this application will identify and characterize new compounds that enhance the efficacy of bronchodilators paving the way for the development of a novel and improved strategy for treating patients with asthma.

PI_NAMEs: DESHPANDE, DEEPAK A (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Adrenergic Receptor;Affect;Affinity;Agonist;Air Movements;Airway Disease;airway epithelium;airway hyperresponsiveness;Airway Resistance;Allosteric Site;Animals;Arrestins;Asthma;asthma model;beta-2 Adrenergic Receptors;beta-adrenergic receptor;beta-arrestin;Binding;Binding Sites;Biological Assay;Biological Models;Biology;bronchial epithelium;Bronchoconstriction;Bronchodilation;Bronchodilator Agents;Cell Proliferation;Cell surface;Cells;Cessation of life;Chemicals;Chronic;chronic inflammatory disease;Clinical;clinically relevant;Combined Modality Therapy;Complex;computerized tools;Coupling;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Databases;desensitization;design;Development;Dimensions;Drug Targeting;drug-like compound;Effector Cell;Epithelial Cells;Evaluation;experimental analysis;Experimental Models;Feedback;functional group;G-Protein-Coupled Receptors;Gene Expression;Generations;GTP-Binding Proteins;Guidelines;Human;immunoregulation;improved;in vivo;in vivo Model;Inhalation;innovation;Ligand Binding;Ligands;Lung;Mediating;Medicine;methacholine;Molecular;Molecular Conformation;molecular dynamics;molecular site;Morbidity - disease rate;mouse model;Mucous body substance;Mus;Muscle Contraction;Muscle function;Muscle relaxation phase;novel;novel therapeutics;Obstructive Lung Diseases;Pathology;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacology;Phosphorylation;Phosphotransferases;positive allosteric modulator;Preventive;Production;Proliferating;prophylactic;Prophylactic treatment;Proteins;Publishing;pulmonary function;Pyroglyphidae;rational design;receptor;Recommendation;recruit;Regulation;Relaxation;Resistance;respiratory smooth muscle;Safety;Sampling;screening;side effect;Signal Pathway;Signal Transduction;simulation;Site;Slice;small molecule;Smooth Muscle;Smooth Muscle Myocytes;Structure;Symptoms;Tachyphylaxis;temporal measurement;Testing;Therapeutic;trafficking;Transducers;Transgenic Mice;Treatment Efficacy;Work

PROJECT_TITLE: Allosteric modulation of beta2- adrenoceptors in the treatment of asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Cancer;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH RELEVANCE Our research group recently demonstrated that B7-H3 targeting therapeutics are effective in the early phases of clinical trials for prostate cancer patients. While novel targeted strategies are actively developed, there are still questions of why only certain patients respond. We will test the hypothesis that additional tumor and clinical features regulate therapy response, which includes B7-H3 transcription regulators and clinical agents that perturb AR signaling.

PI_NAMEs: HWANG, JUSTIN H. (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Ablation;Advanced Development;Aftercare;Algorithms;Androgen Receptor;Androgens;Behavior;Binding;Biological;Biology;Biopsy;Cancer Patient;CD276 gene;Cell Line;Cell surface;Cells;Characteristics;ChIP-seq;Clinical;Clinical Trials;cofactor;cohort;Computer Models;CRISPR/Cas technology;CTLA4 gene;Data Set;Development;Disease;early phase clinical trial;Enhancers;Exhibits;exome;Experimental Models;experimental study;Future;Genes;Genetic Enhancer Element;Genetic Transcription;high risk;improved;insight;Laboratories;Legal patent;Localized Disease;Malignant neoplasm of prostate;Membrane Glycoproteins;Metastatic Prostate Cancer;Methods;Modeling;Molecular;Monoclonal Antibodies;neoplastic cell;neural network;novel;Outcome;patient derived xenograft model;patient response;patient stratification;Patients;Phase;Phase II Clinical Trials;precision oncology;predicting response;Predisposition;programmed cell death ligand 1;programs;prostate cancer cell;Prostate Cancer therapy;public health relevance;Publishing;Receptor Signaling;Regulator Genes;Research;research clinical testing;Research Design;Resistance;Resistance development;response;Sampling;Scheme;sequencing platform;Signal Transduction;single-cell RNA sequencing;Site;Specimen;standard of care;targeted agent;targeted treatment;Testing;Therapeutic;therapeutically effective;therapy resistant;tool;transcription factor;transcriptome;treatment response;tumor

PROJECT_TITLE: Dissecting mechanisms of sensitivity to B7-H3 (CD276)-targeted therapeutics in prostate cancer (PC)

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Genetics;Hematology;Orphan Drug;Ovarian Cancer;Pediatric;Pediatric Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: NARRATIVE Therapy related myeloid neoplasms (tMNs), including acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), are malignancies of the bone marrow that occur in patients who have received prior anti- cancer therapy. Additional studies have shown that PARP inhibitors, a recently developed class of drugs that extend relapse-free and overall survival when administered to ovarian cancer (OC) patients as maintenance therapy after initial chemotherapy and surgery, increase the already high rate of tMNs in OC patients. These tMNs typically have mutations in the TP53 gene that make them relatively insensitive to conventional anti- leukemic treatments. Building on preliminary studies showing that a class of targeted agents called replication checkpoint modulators is active against TP53-mutant AML, we now propose to i) study the underlying mechanism by which replication checkpoint modulators kill TP53-mutant AML and ii) assess the activity of replication checkpoint modulators against tMNs isolated from OC patients. Collectively, these studies will provide insight into the subset of tMNs that are most likely to respond to replication checkpoint modulators and position the team to test this new class of antineoplastic agent in OC survivors who develop tMNs.

PI_NAMEs: KAUFMANN, SCOTT H (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Abbreviations;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acute Promyelocytic Leukemia;Adverse event;Alleles;antagonist;antileukemic activity;Antineoplastic Agents;Apoptotic;Biological Models;Bone Marrow;Bone Marrow Diseases;BRCA1 gene;BRCA2 gene;Cancer Patient;Cancer Survivor;cancer therapy;Carboplatin;Caspase;CDK2 gene;Cell Line;Cessation of life;CHEK1 gene;chemotherapy;Clinical;Clinical Trials;Communities;Copy Number Polymorphism;crosslink;cytotoxic;cytotoxicity;Decitabine;design;Disease remission;DNA Repair Pathway;Dysmyelopoietic Syndromes;early phase clinical trial;effective therapy;efficacy evaluation;efficacy study;Exhibits;Fatality rate;Future;Gene Silencing;Genes;homologous recombination;homologous recombination deficiency;Immune checkpoint inhibitor;improved;In Vitro;in vitro Model;in vivo;Incidence;Induction of Apoptosis;inhibitor;inhibitor therapy;insight;kinase inhibitor;Lead;leukemia;leukemia treatment;Leukemic Cell;Maintenance;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;MAPK8 gene;Mediating;member;mimetics;Mitochondria;mortality;multidisciplinary;mutant;Mutation;Myeloproliferative disease;Oncogenic;Oncology;Operative Surgical Procedures;Ovarian;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;peritoneal cancer;Pharmaceutical Preparations;phase 2 testing;Phosphotransferases;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical efficacy;protein activation;Proteins;RAD51C gene;Relapse;Research;Resistance;response;Risk;Role;Sampling;Serous;Solid Neoplasm;Specimen;standard of care;synergism;targeted agent;Testing;Therapeutic;therapy development;TNF gene;TP53 gene;TP53 Gene Inactivation;TP53-mutant acute myeloid leukemia;Transactivation;transcription factor;Transcription Factor AP-1;Treatment Efficacy;Tumor Necrosis Factor Receptor;Tumor Suppressor Proteins;Woman;Xenograft procedure

PROJECT_TITLE: Therapy of PARP inhibitor-associated myeloid neoplasms in ovarian cancer patients

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Nanotechnology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Effective control of advanced oral squamous cell carcinoma (OSCC) remains a clinical challenge. The therapeutic efficacy of cetuximab (CTX)-based anti-epidermal growth factor receptor (EGFR) therapy is unsatisfactory in limiting OSCC, which can be significantly improved in combination with IACS-010759 (IACS), an orally bioavailable mitochondrial complex I inhibitor, by inducing pyroptosis-mediated anti-tumor immunity. Successful completion of this project will provide a comprehensive understanding of the molecular and immunological mechanisms of CTX/IACS combination, leading to an improved therapy that maximizes anti- tumor efficacy while minimizing toxicity.

PI_NAMEs: TENG, YONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Biological Availability;C57BL/6 Mouse;Cancer Model;CD8-Positive T-Lymphocytes;Cell Line;Cell model;Cell Survival;Cetuximab;Clinical;clinical translation;Combined Modality Therapy;Complex;CRISPR/Cas technology;Data;Development;Diagnosis;Disease;draining lymph node;effective therapy;Epidermal Growth Factor Receptor;FDA approved;genome-wide;Goals;Head and Neck Cancer;Human;Immune;Immune system;Immunologics;immunoregulation;Immunotherapy;improved;Inflammasome;inhibitor;insight;Knock-out;Malignant Epithelial Cell;malignant mouth neoplasm;Mediating;Mitochondria;Modeling;Molecular;mortality;mouse model;Mouth Neoplasms;mouth squamous cell carcinoma;Mus;nanoparticle;Nanotechnology;neoplastic cell;novel;Oral;Organoids;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Perfusion;Phase I Clinical Trials;Pilot Projects;pre-clinical;Pre-Clinical Model;programmed cell death protein 1;Reactive Oxygen Species;Recurrence;Remission Induction;Resistance development;Role;Safety;Scheme;screening;Signal Transduction;Survival Rate;Technology;Testing;Therapeutic;therapy design;TNF gene;Toxic effect;Treatment Efficacy;treatment strategy;tumor;tumor growth;Tumor Immunity;TXNIP gene;Xenograft Model

PROJECT_TITLE: Inhibiting mitochondrial complex I to improve cetuximab efficacy in oral cancer


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This project uses cutting-edge approaches to establish how developmental exposure to a PFAS mixture affects the immune system. In the context of fighting human respiratory virus infection, we will define how PFAS influence immune function at cellular levels, parse sex differences, and establish dose-response relationships.

PI_NAMEs: LAWRENCE, B PAIGE  (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acids;Address;Affect;Affinity;Alkanesulfonates;Antibodies;Antibody Formation;Antibody Response;B-Lymphocytes;Body Fluids;CD4 Positive T Lymphocytes;Cell Transplantation;Cells;cellular targeting;Clinical;cohort;Cohort Studies;Communicable Diseases;conditional knockout;Coupled;critical period;Data;defined contribution;Development;Dimensions;Dose;early life exposure;epidemiology study;Event;experimental study;Exposure to;fetal;fighting;Flow Cytometry;Goals;Health;Helper-Inducer T-Lymphocyte;high dimensionality;High Pressure Liquid Chromatography;Human;human population study;Humoral Immunities;Immune;immune function;Immune response;Immune system;immune system function;Immunity;Immunoglobulin Class Switching;Immunologic Memory;immunoregulation;immunotoxicity;improved;in utero;in vivo;Infant;Infection;Influenza A virus;interleukin-21;Kinetics;Knockout Mice;Knowledge;Life;Link;Marketing;Mass Spectrum Analysis;Measures;Mediating;Memory;Mothers;mouse model;Mus;Nature;novel;offspring;Organic Chemicals;perfluorohexane;perfluorooctane sulfonate;perfluorooctanoic acid;Peroxisome Proliferator-Activated Receptors;Persons;pharmacologic;Plasma Cells;Poly-fluoroalkyl substances;Population;Population Study;Populations at Risk;postnatal;Pregnant Women;Receptor Signaling;receptor-mediated signaling;Reporting;Research;Research Project Grants;Resolution;respiratory infection virus;Respiratory Tract Infections;respiratory virus;response;Serum;sex;Sex Differences;Structure of germinal center of lymph node;Study models;T-Lymphocyte;Testing;time use;Uncertainty;Vaccination;Viral;Virus Diseases

PROJECT_TITLE: Developmental immunotoxicity of PFAS

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

PHR: Project Narrative Aging is the most important risk factor for many common afflictions and interventions to biological aging might prevent, delay, or even cure, chronic age-related diseases. This proposal will use a unique model well-suited to identify mechanisms by which cells can supersede normal species lifespan boundaries without undergoing senescence or malignant transformation, while redressing fundamental and longstanding biological concepts. Outcomes of the proposal will identify opportunities to decelerate or stop aging though therapeutic interventions.

PI_NAMEs: MASOPUST, DAVID  (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: age acceleration;age related chronic disease;age related decline;aged;Aging;aging mechanism;Antigens;antimicrobial;Biological;Biological Aging;Biological Models;Cell division;Cell Maintenance;Cell model;Cell Physiology;Cells;Chromosome abnormality;Chronology;cohort;Competence;Cues;Data;Deceleration;Environment;Essential Genes;Exhibits;Genetic Transcription;Goals;Growth;healthspan;Human;improved;in vivo;Inflammaging;insight;Intervention;Learning;life span;Longevity;Maintenance;Malignant - descriptor;Mammalian Cell;Measures;Memory;Metabolic;mitochondrial fitness;Mitogens;Modeling;Mus;Mutation;Noise;old mice;Outcome;Physiological;Population;preservation;prevent;Proliferating;Recording of previous events;Regulation;Resistance;response;Risk Factors;Sampling;senescence;Somatic Cell;Sorting;Stereotyping;Sterile coverings;T memory cell;T-Lymphocyte;Testing;Therapeutic Intervention;Work;Youth

PROJECT_TITLE: Using an in vivo multi-lifetime model to test mechanisms of aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Reelin signaling plays a pivotal role in memory formation and serves as a protective pathway against Alzheimer’s disease (AD). A crucial aspect of Reelin’s effectiveness in enhancing synaptic plasticity hinges on its cognate receptors, APOER2 and VLDLR, which are characterized by a high degree of alternative splicing. This proposal aims to understand the mechanisms underlying the impact of receptor splicing on ligand-receptor interactions and signaling, and how these dynamics affect neuronal function and susceptibility to AD.

PI_NAMEs: BEFFERT, UWE ;HO, ANGELA  (contact);TCW, JULIA

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Affect;Age;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease risk;Amyloid;apolipoprotein E receptor 2;Autopsy;autosomal dominant Alzheimer's disease;Binding;Biological;Biology;Brain;Brain region;Cell Physiology;Cognitive;Cognitive deficits;cognitive function;cohort;CRISPR-mediated transcriptional activation;Data;density;Development;Disease;Disease susceptibility;Effectiveness;entorhinal cortex;Etiology;Event;Functional disorder;Gene Expression;gene function;Genes;Genetic;glycogen synthase kinase 3 beta;Goals;Heterozygote;Hippocampus;Human;hyperphosphorylated tau;Impairment;Induced pluripotent stem cell derived human neuron;insight;Length;Ligand Binding Domain;Ligands;Maps;Mediating;Memory;mild cognitive impairment;Molecular;mouse genetics;mouse model;Mutation;Neurofibrillary Tangles;Neurons;neuroprotection;Paint;Pathogenesis;Pathology;Pathway interactions;Phenotype;Phosphorylation Site;Play;Population;Predisposition;preservation;Prevalence;protective pathway;proteogenomics;receptor;Receptor Signaling;reelin receptor;Research Proposals;resilience;Risk;RNA Splicing;Role;Senile Plaques;Signal Pathway;Signal Transduction;single molecule;synaptic function;Synaptic plasticity;tau Proteins;tau-1;Testing;Therapeutic;Transcript;transcriptome;transcriptomics;treatment strategy;Variant

PROJECT_TITLE: Reelin and Receptor Splicing in Alzheimer's Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE NIAID is supporting the development of a new research Network comprised of a Coordinating and Data Sharing Center (CDSC) and Research Centers to collaboratively produce generalizable knowledge that enables rapid pandemic response to emerging viral pathogens. The overall goal of the RTI International-based CDSC is to establish and maintain an integrated Network to accelerate discovery and dissemination of novel vaccine and monoclonal antibody strategies to prepare for the next pandemic outbreak. This will be accomplished by leveraging RTI multidisciplinary experts and providing centralized administrative communication and operational support for Network-wide activities, while establishing data sharing and analysis standards and platforms.

PI_NAMEs: HANLON, SEAN T.;SEMPOWSKI, GREGORY D (contact)

PROGRAM_OFFICER_NAME: SMITH, RACHELLE MARIE SIMPSON

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Administrative Efficiency;Administrator;Agreement;Antibodies;Antigens;Basic Science;Biometry;Bunyavirales;Collaborations;combat;Communication;Coronavirus;COVID-19 pandemic;Data;Data Analyses;Data Coordinating Center;data hub;data management;data repository;Data Science;data sharing;design;Development;Disease;Disease Outbreaks;Ecosystem;Emerging Communicable Diseases;emerging pathogen;empowerment;Ensure;Family;Family Picornaviridae;future pandemic;Goals;Government;Group Structure;high risk;HIV;Human;Hypersensitivity;Infection;Influenza;influenzavirus;innovation;International;Investments;Knowledge;Leadership;member;metadata standards;Mission;Monoclonal Antibodies;multidisciplinary;National Institute of Allergy and Infectious Disease;new pandemic;novel;novel vaccines;organizational structure;outbreak response;pandemic disease;pandemic potential;pandemic preparedness;pandemic response;Paramyxovirus;pathogenic virus;pathogens of pandemic potential;Performance;preclinical study;Privatization;programs;Qualifying;Readiness;Reagent;Real-Time Systems;Reporting;Research;research and development;Research Design;Research Personnel;Resources;response;RNA vaccine;Secure;Structure;support network;System;Technology;tool;Translational Research;vaccine delivery;vaccine development;vaccine-induced antibodies;Vaccines;Viral;viral outbreak;viral pandemic;Virus;working group

PROJECT_TITLE: Coordinating and Data Sharing Center - R&D of Vaccines and Antibodies for Pandemic Preparedness (ReVAMPP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 NKD-M (J1)]


ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Asthma, accompanied by lung inflammation, bronchoconstriction, and airway hyperresponsiveness, is a significant public health burden. Although recent basic and clinical research has led to a better understanding of the immunological mechanisms of asthma, the neural mechanisms underlying asthma symptoms remain unclear. This proposal aims to investigate how vagal sensory neurons contribute to asthma symptom.

PI_NAMEs: HAN, LIANG  (contact)

PROJECT_TERMS: Ablation;Affect;afferent nerve;Afferent Neurons;Airway Disease;airway hyperresponsiveness;airway inflammation;airway mucous cell metaplasia;airway obstruction;allergic airway inflammation;Allergic inflammation;Anti-Inflammatory Agents;Asthma;asthma model;asthmatic;ATAC-seq;Basic Science;Biological Assay;Bronchi;Bronchoconstriction;Calcium;cell type;Cells;cholinergic;Clinical Research;constriction;cytokine;Data;Development;Disease;Dissociation;Electrophysiology (science);Embryo;Epigenetic Process;epigenomics;Extrinsic asthma;Fluorescence-Activated Cell Sorting;Ganglia;Gene Expression Profile;gene regulatory network;Image;Imaging Techniques;Immune;Immunologics;in vivo;Induced Neurons;Inflammatory;Inflammatory Response;Interleukin-4;Label;Lung;Mechanics;Mediating;Molecular Profiling;Monitor;Mus;Nerve;nerve supply;Neuroimmune;neuromechanism;Neurons;neuroregulation;novel;novel therapeutic intervention;oncostatin M;OSMR gene;patch clamp;Pattern;Peripheral;Physiological;Play;Population;Population Control;Property;Pruritus;Public Health;Pulmonary Inflammation;receptor;response;Role;Skin;Survival Rate;Symptoms;System;Testing;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Interoceptors controlling airway constriction

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Chemotherapy-induced painful peripheral neuropathy (CIPPN) often leads to treatment failure and significantly reduces quality of life. The proposal will discover and validate whether peroxisome proliferator activated receptor gamma (PPARγ) and low-density lipoprotein receptor related protein 1 (LRP1) signaling limits Schwann cell dysfunction, and thereby alleviates aberrations in neuronal bioenergetics and hyperexcitability induced by chemotherapy. A deeper understanding of molecular mechanisms of Schwann cell function, neuroprotection and repair will help develop targeted therapies to treat CIPPN.

PI_NAMEs: CAMPANA, WENDY M.;YE, YI  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: abuse liability;Acute inflammatory pain;Address;Afferent Neurons;Agonist;Anti-Inflammatory Agents;Behavior;Behavioral Assay;Bioenergetics;Biological Models;cancer cell;Cancer Model;Cancer Patient;Cell Physiology;Cell Survival;Cells;chemokine;chemotherapeutic agent;chemotherapy;chronic pain;chronic pain management;clinical development;clinical translation;Clinical Trials;clinically relevant;Coculture Techniques;cytokine;Data;design;Development;diabetes management;Dorsal;Drug Targeting;Exhibits;FDA approved;Flow Cytometry;Functional disorder;Ganglia;genetic manipulation;glucose metabolism;Health;Heterogeneity;Histopathology;Homeostasis;Human;human model;Hypersensitivity;Immune;immune cell infiltrate;immunoregulation;improved;In Vitro;Inflammation;Injury;innovation;Knowledge;LDL-Receptor Related Protein 1;Ligands;lipid metabolism;Lipoprotein Receptor;Macrophage;malignant mouth neoplasm;Measures;Mediating;Metabolic;Migration Assay;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Monitor;Motor;Mus;Natural Immunity;Nerve;nerve damage;Nerve Degeneration;nerve repair;Nervous System Disorder;Neuroglia;neuroinflammation;neuronal metabolism;Neurons;neuroprotection;Nociception;novel;Operative Surgical Procedures;oxaliplatin;Oxidative Stress;Oxidative Stress Induction;Paclitaxel;Pain;Pain management;painful neuropathy;patch clamp;Patients;Peripheral;Peripheral Nervous System Diseases;pharmacologic;Play;PPAR gamma;Predisposition;prevent;Prevention;Preventive therapy;Proteins;Publishing;Punch Biopsy;Quality of life;recruit;Regulation;repaired;Reporter;Reporting;Research;Respiration;respiratory;response;Role;Safety;Schwann Cells;sciatic nerve;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spinal Ganglia;System;targeted treatment;Techniques;Testing;Therapeutic;Tissues;Tongue;Toxicity due to chemotherapy;transcription factor;Treatment Failure;tumor;tumor growth;validation studies;Work

PROJECT_TITLE: Targeting Schwann cell dysfunction and repair signaling in chemotherapy induced painful peripheral neuropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Z (55)]