ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: NARRATIVE: Overall As demonstrated by the COVID-19 pandemic, infectious diseases are continuously evolving threats that cause substantial morbidity and mortality in all populations. Toward the prevention and control of globally important infectious diseases, we propose continuation of the Translational Global Infectious Diseases Research (TGIR) Center. The TGIR Center supports the research and career development of the next generation of scientists in biomedical and quantitative/computational scientific fields and builds a strong collaborative research team to diminish the global health burden from infectious diseases.

PI_NAMEs: KIRKPATRICK, BETH DIANE (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: academic program;Advisory Committees;Applications Grants;Area;Award;biobank;career;career development;Centers of Research Excellence;Clinical;Collaborations;Communicable Diseases;Complement;Computer Models;Core Facility;COVID-19 pandemic;data management;Data Scientist;Dedications;design;Development;Discipline;Education;Evaluation;experience;Faculty;Faculty Recruitment;faculty support;Fostering;Funding;global health;Goals;Grant;Growth;Human;improved;Individual;Infectious Diseases Research;Institution;interest;Language;Leadership;Logistics;Mathematics;meetings;member;Mentors;Mission;Modeling;Morbidity - disease rate;mortality;multidisciplinary;next generation;novel;Phase;Physicians;Pilot Projects;Population;Population Research;Positioning Attribute;predictive modeling;prevent;Prevention;Process;Program Development;programs;recruit;Reporting;Research;research and development;Research Personnel;Research Project Grants;Research Support;Research Training;Resource-limited setting;Role;Scholars Program;Science;Scientist;senior faculty;Services;Structure;success;Training and Education;training opportunity;Training Programs;Universities;Update;Vermont;visiting scholar

PROJECT_TITLE: Translational Global Infectious Diseases Research Center


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Nutrition;Pediatric;Polycystic Kidney Disease

ORG_CITY: KANSAS CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Autosomal-dominant polycystic kidney disease (PKD) is characterized by the formation of numerous fluid-filled renal cysts, immune cell infiltration and interstitial fibrosis which lead to a gradual decline in kidney function. As functional nephron numbers are reduced, phosphate excretion by residual nephrons is dramatically increased to preserve phosphate balance, which may promote further kidney injury. Preliminary data from our group has revealed dietary phosphate restriction to slow PKD progression in mice; therefore, we plan to perform experiments using cell culture techniques and genetically altered mouse models to identify the mechanisms whereby phosphate may promote PKD progression.

PI_NAMEs: STUBBS, JASON  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acceleration;Affect;Attenuated;Autosomal Dominant Polycystic Kidney;Binding;calcium phosphate;Cell Culture Techniques;cell injury;Cell Proliferation;Chronic;Chronic Kidney Failure;clinical practice;Consumption;Crystal Formation;Crystallization;Cyst;Cystic kidney;Cystic Kidney Diseases;Data;Deposition;dietary;dietary excess;Dietary intake;Dietary Intervention;Disease;Disease Progression;End stage renal failure;Epithelial Cell Proliferation;Epithelial Cells;Epithelial cyst;Equilibrium;Event;Excretory function;Exhibits;experimental study;fibroblast growth factor 23;Fibrosis;FRAP1 gene;Functional disorder;Generations;Genetic;Growth;Hormones;Human;immune cell infiltrate;improved;In Vitro;Infiltration;Ingestion;inhibitor;Injury;Injury to Kidney;inorganic phosphate;Integrin alphaV;Integrin Binding;integrin-linked kinase;Integrins;interstitial;Kidney;Kidney Diseases;kidney fibrosis;Liquid substance;Location;Macrophage;Maintenance;Mediating;Metabolism;Methods;Minerals;mouse model;Mus;nanocrystal;Nephrons;nephrotoxicity;novel;novel therapeutic intervention;Oral;osteopontin;Pathologic;Pathology;Pathway interactions;Peptides;pharmacologic;PKD1 gene;Polycystic Kidney Diseases;preservation;Prevalence;prevent;Production;Proteins;recruit;Renal function;Residual state;RGD (sequence);Rodent;Rodent Model;Role;Signal Transduction;Site;sodium-phosphate cotransporter proteins;Solubility;Stimulation of Cell Proliferation;Testing;theories;Tissues;Translations;Tubular formation;urinary;Urine

PROJECT_TITLE: Impact of Phosphaturia on Renal Osteopontin Production and PKD Progression

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Infectious Diseases

PROJECT_TERMS: Advisory Committees;Award;career;career development;Centers of Research Excellence;Collaborations;Communicable Diseases;Communication;Core Facility;Decision Making;Dedications;Development;Education;experience;Faculty;Faculty Recruitment;faculty research;Funding;Goals;Grant;Growth;Growth and Development function;Human;improved;Infectious Diseases Research;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Lead;Leadership;Mathematics;Mentors;Morbidity - disease rate;mortality;multidisciplinary;next generation;operation;Phase;Pilot Projects;Population Research;Positioning Attribute;predictive modeling;Principal Investigator;Program Development;programs;recruit;Research;Research Personnel;Research Project Grants;Running;Scholars Program;scientific hub;Services;Strategic Planning;symposium;Universities;Update;visiting scholar;Writing

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will optimize a powerful platform of genetic tools for chronic, large-scale, non-invasive imaging of neuromodulation in the brain during behavior. This is relevant to NIH’s mission because these tools will permit new classes of experiments that reveal the role these important molecules play in regulating addiction, attention, cognition, mood, memory, motivation, and sleep, and how aberrant neuromodulation causes many neurological disorders.

PI_NAMEs: HIRES, SAMUEL ANDREW (contact);LI, YULONG

PROGRAM_OFFICER_NAME: TALLEY, EDMUND M

PROJECT_TERMS: Acetylcholine;addiction;adenovirus mediated delivery;Affinity;Attention;Behavior;Brain;Brain region;Calcium;Chronic;Cognition;Collaborations;Color;Complex;confocal imaging;cost effective;Cre driver;Deposition;Dimensions;Dopamine;Engineering;experimental study;Fiber;Fluorescence;Functional disorder;G-Protein-Coupled Receptors;Generations;Genetic;genetic approach;Goals;Image;improved;In Vitro;in vivo;in vivo imaging;Injections;invention;Lead;Libraries;Ligands;Light;Measures;Membrane Proteins;Memory;Mission;Molecular;Moods;Motivation;multiplexed imaging;Mus;mutant;Nervous System Disorder;neural circuit;Neuromodulator;neuroregulation;non-invasive imaging;Norepinephrine;Opsin;optogenetics;Performance;photoactivation;Photometry;Photons;Plasmids;Play;prevent;Public Health;red fluorescent protein;Reporter;Research;Research Personnel;Resolution;response;Role;screening;sensor;Serotonin;Signal Transduction;Site;Sleep;Slice;somatosensory;Structure;temporal measurement;Tissues;tool;two-photon;United States National Institutes of Health;uptake;Validation;Vertebral column;virus genetics;voltage

PROJECT_TITLE: Optimization of GPCR-based fluorescent sensors for large-scale multiplexed in vivo imaging of neuromodulation


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Arthritis and other rheumatic diseases are major unmet medical needs, through high-quality mentoring in a broad-based and interactive research environment, this T32 program will support the training of outstanding MD and PhD investigators.

PI_NAMEs: JACKSON, SHAUN WILLIAM;MUSTELIN, TOMAS M (contact);RAWLINGS, DAVID J

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Research Training;Rheumatology

PROJECT_TITLE: Research Training in Rheumatology


PI_NAMEs: PIERCE, KRISTEN  (contact)

PROJECT_TERMS: Address;Area;base;biobank;Biometry;Centers of Research Excellence;Clinical;Clinical Investigator;Clinical Research;Communicable Diseases;Complement;Complex;Consultations;COVID-19 pandemic;Crystallization;Data Analyses;data management;Dedications;design;Development;Education;Educational Curriculum;Ethics;experience;Faculty;Goals;Growth;Human;improved;Infectious Diseases Research;Institution;Knowledge;Lead;Mathematics;Mission;Morbidity - disease rate;mortality;next generation;Phase;Physicians;Pilot Projects;Population Research;predictive modeling;professor;programs;Public Health;public health research;Regulatory Affairs;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Role;Rotation;Scientist;Series;service utilization;Services;skills;Specimen;Specimen Handling;statistics;Structure;synergism;Training;Training and Education;Training Programs;translational health science;Translational Research;Update;vaccine evaluation;Work

PROJECT_TITLE: Human and Population Research Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: The cross-species emergence of SARS-CoV-2 from wild, Rhinolophus spp. bats to human hosts highlights the extreme public health, economic, and societal consequences that can result from zoonotic spillover. This proposal leverages tools from mathematical modeling, field biology, and molecular immunology to decipher the mechanisms underpinning the circulation of bat-borne viruses at a population-level, understand the processes which shape their pathology within-host, and eradicate them from reservoir populations to prevent future threats of zoonotic emergence.

PI_NAMEs: BROOK, CARA  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: 2019-nCoV;Address;African;Animals;Anti-Inflammatory Agents;antiviral immunity;bat-borne;betacoronavirus;Biology;Canis familiaris;Case Fatality Rates;Cell Line;Chicago;Chiroptera;chronic infection;Circulation;Clinical;Collaborations;Communicable Diseases;Communities;Consumption;Coronavirus;cost effective;Coupled;COVID-19 pandemic effects;cross-species transmission;Data;design;Discipline;Disease;Disparate;Doctor of Philosophy;Ebola;Ecology;Economics;Ecosystem;Evolution;Exhibits;experience;exposed human population;Exposure to;field study;Filovirus;Food;Fruit;Future;Goals;Hendra Virus;Henipavirus;Henipavirus Infections;Human;Immune;Immune system;Immunity;Immunologics;immunopathology;Infection;Infection Control;infectious disease model;Innate Immune Response;innovation;interest;Intervention;Island;Jamaican;Laboratories;Learning;Link;Literature;Madagascar;Mammals;Marburgvirus;mathematical model;Measles;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;Molecular Immunology;Monitor;Nature;Nipah Virus;novel;Nutritional;pandemic preparedness;Paramyxovirus;pathogen;Pathology;Pattern;Periodicals;Physiologic pulse;Physiological;Physiology;Population;Population Sizes;Population Study;post-doctoral training;Postdoctoral Fellow;prevent;Prevention;Process;professor;Public Health;Rabies virus;Recommendation;Recrudescences;Regimen;reproductive;Research;Resources;Sampling;Seasonal Variations;Seasons;Series;Serology;Severe Acute Respiratory Syndrome;Shapes;skills;Source;spillover event;Stress;stressor;System;Techniques;Testing;therapy design;Time;tool;transmission process;United States National Institutes of Health;Universities;Vaccinated;Vaccination;vaccine distribution;Vaccines;Viral;Viral Load result;viral transmission;Virulent;Virus;Virus Diseases;Virus Shedding;willingness;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Crossing scales to predict and prevent bat virus zoonoses in a Madagascar ecosystem


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Obesity, diabetes, high carbohydrate diets, alcohol excess and thyroid disorders all contribute to high circulating triglyceride levels, which are found in more than half of women with triple negative breast cancer. Triple negative breast cancers are specifically susceptible to the growth promoting effects of high circulating triglycerides. Through our studies we will uncover how elevated circulating triglycerides contribute to triple negative breast cancer development and spread, and determine if starving triple negative cancer cells of these lipids will prove to be their Achilles’ heel which can be exploited as a novel therapeutic strategy.

PI_NAMEs: GALLAGHER, EMILY JANE (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Adult;Affect;aggressive breast cancer;Alcohols;Apolipoproteins;Biological;breast cancer diagnosis;Breast Cancer gene;breast cancer progression;breast cancer survival;cancer cell;cancer subtypes;Carbohydrates;Cardiovascular system;Caring;Cells;Cholesterol;Circulation;clinical care;clinical translation;Clinical Trials;Cytoskeleton;Development;Diabetes Mellitus;Diet;Disease;Energy-Generating Resources;Epidemiology;epidemiology study;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Estrogen Receptors;Fatty Acids;Gene Expression;Genes;genetic signature;Genetically Engineered Mouse;Glycerol;Goals;Growth;Human;Hydroxycholesterols;Hypertriglyceridemia;Hypoxia;Immunocompetent;immunodeficiency;improved outcome;Link;Lipid Peroxidation;lipidome;Lipids;Lipoprotein Binding;Malignant Breast Neoplasm;Measures;Metabolic;Metabolism;Metastatic Neoplasm to the Lung;Mitogen-Activated Protein Kinases;Modeling;molecular subtypes;mortality;mouse model;Mus;Neoplasm Metastasis;neutrophil;Newly Diagnosed;novel therapeutic intervention;novel therapeutics;Obesity;Oncology;patient derived xenograft model;Peroxisome Proliferator-Activated Receptors;Phospholipids;Phosphorylation;Pre-Clinical Model;preclinical study;Predisposition;Primary Neoplasm;progesterone receptor negative;Prognosis;rapid growth;receptor expression;Receptor Signaling;Recurrence;Research;Serum;Signal Transduction;Signaling Molecule;Starvation;Sterols;Therapeutic;Thyroid Diseases;transcriptome sequencing;transcriptomics;Translating;Triglycerides;triple negative cancer;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Promotion;tumor-immune system interactions;uptake;Very low density lipoprotein;very low density lipoprotein triglyceride;VLDL receptor;Woman;women's outcomes

PROJECT_TITLE: Understanding how elevated triglycerides contribute to triple negative breast cancer growth and metastasis

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases;Prevention

PI_NAMEs: HÉBERT-DUFRESNE, LAURENT  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Affect;antimicrobial;Antimicrobial Resistance;Area;Attention;Behavior;Behavioral;Biological;Biology;Biomedical Computing;biomedical scientist;bridge program;Centers of Research Excellence;Clinical;Collaborations;Communicable Diseases;Communication;Complex;Computer Models;Conscious;COVID-19 pandemic;current pandemic;design;Development;Diagnostic tests;Disease;disease transmission;disorder control;Doctor of Philosophy;Education;education research;Epidemic;Epidemiology;experience;Eye;Faculty;Fostering;Funding;Goals;Growth;Human;Immune response;Immunologics;improved;Inequity;Infectious Diseases Research;Inflammatory;Institution;interest;Intervention;Knowledge;Language;low and middle-income countries;mathematical model;Mathematics;Measures;microbiome;Mission;Modeling;Morbidity - disease rate;mortality;next generation;pandemic disease;pathogen;Pattern;Phase;Pilot Projects;Play;Population;predictive modeling;Predisposition;pressure;prevent;programs;Public Health;Research;Research Personnel;Research Project Grants;Research Support;response;Risk;Role;Scientist;Services;Societies;Structure;synergism;Testing;Therapeutic;Time;tool;Training;Uncertainty;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Mathematical, Computational, and Predictive Modeling Core


NIH_SPENDING_CATS: Infectious Diseases

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative The continued emergence of new pathogens such as SARS-CoV-2, the unacceptable morbidity and mortality due to conventional infections, and the epidemics of antibiotic-resistant bacteria highlight the need for well- trained researchers in infectious diseases. This postgraduate training program in infectious diseases will provide training for investigators capable of harnessing the discoveries in the basic sciences of microbiology and immunology to develop novel interventions aimed at ameliorating the burden of infectious diseases.

PI_NAMEs: HAWKINS, CLAUDIA A (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TITLE: Northwestern University Infectious Diseases Education and Science (NuIDeas)

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Mental Health;Neurosciences

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative  The research proposed here will elucidate visual functioning in healthy human populations. Understanding how we build integrated representations of 3D space and objects – and update them across saccades – may offer critical clues for treatment of visual disorders including strabismus, macular degeneration, stereo-blindness, and neglect, and can inform development of effective visual prosthetics for blind individuals. Additionally, better knowledge of these fundamental processes may hold broad clinical applications for aging, autism, schizophrenia, and depression (all accompanied by changes in visual processing).

PI_NAMEs: GOLOMB, JULIE D (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;Affect;Aging;Attention;attentional control;autism spectrum disorder;Award;Back;Behavior;Binding;Blindness;Brain;Brain Injuries;clinical application;Code;Cognitive;cognitive control;cognitive process;Complex;Depth Perception;Development;Electroencephalography;Environment;experience;experimental study;Eye;Eye diseases;Eye Movements;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;Grant;Hippocampus;Human;improved;Injury;Knowledge;Light;Link;Location;Macular degeneration;Maps;Memory;Mental Depression;Modeling;neglect;neural;neuroimaging;object perception;object recognition;Ocular Prosthesis;Pattern;Perception;Play;Population;Positioning Attribute;Process;programs;rapid eye movement;Research;Resolution;Retina;retinotopic;Role;Saccades;Schizophrenia;Strabismus;Techniques;temporal measurement;theories;tool;Update;Vision;Vision Disorders;Visual;visual cognition;Visual Cortex;visual information;visual neuroscience;Visual Perception;visual processing;Visual System;Visually Impaired Persons

PROJECT_TITLE: Neural and perceptual mechanisms of spatial stability across eye movements

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project narrative This project aims to develop foundational tools for cellular engineering that will enable robust cell-fate programming. Using a combination of stem cell biology, systems biology, synthetic biology, and chromatin engineering, we will define the molecular regulatory rules of cell-fate transitions. Harnessing these design rules will enable the forward design of sophisticated genetic programs capable of robustly regulating gene expression in primary cells to support gene- and cell-based therapies for application in regenerative medicine.

PI_NAMEs: GALLOWAY, KATE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Affect;Behavior;Binding;biological systems;Cell Fate Control;Cell Therapy;Cells;cellular engineering;Chromatin;Chromatin Structure;Cytoskeleton;design;Detection;DNA;Engineering;Enzymes;Epigenetic Process;Event;Gene Expression;gene regulatory network;Gene Silencing;Genes;Genetic;genetic element;Genetic Transcription;Human;improved;Innate Immune Response;insight;Length;metaplastic cell transformation;Molecular;Mus;Oncogenes;Outcome;pathogen;Performance;Phase;Process;programs;Proliferating;quorum sensing;Regenerative Medicine;Regulation;response;Role;Shapes;Signal Transduction;stem cell biology;synthetic biology;Synthetic Genes;System;Systems Biology;three dimensional structure;tool;transgene delivery;Transgenes;tumor;Work;Writing

PROJECT_TITLE: Multiscale tools and approaches for understanding and engineering cell-fate transitions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Genetics;Infectious Diseases;Influenza;Pneumonia and Influenza

PI_NAMEs: BRUCE, EMILY A. (contact)

PROJECT_TERMS: 2019-nCoV;Acute;Affect;Air;Animals;Anti-viral Agents;Biological Assay;Cell Line;Centers of Research Excellence;Choking;Clinical;clinical decision-making;Complex;Coronavirus;cost;COVID-19;COVID-19 detection;COVID-19 diagnostic;COVID-19 pandemic;COVID-19 patient;COVID-19 testing;current pandemic;Death Rate;Detection;Diagnosis;Diagnostic;Diagnostic tests;DNA Sequence Alteration;Doctor of Philosophy;FDA Emergency Use Authorization;Free Will;Funding;Future;future pandemic;Genetic;global health;Goals;Guidelines;Healthcare Systems;improved;Individual;Infectious Diseases Research;Influenza;influenza virus strain;influenzavirus;Liquid substance;Maintenance;Molecular;Morphology;mortality;novel;open source;pandemic disease;pandemic influenza;pandemic potential;particle;Patients;personal protective equipment;Phase;Phenotype;Physiological;Pilot Projects;Play;pressure;Process;Property;Protocols documentation;Public Health;Publications;Quarantine;Reagent;Research Project Grants;Residual state;Resources;respiratory;Respiratory System;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA;RNA Viruses;Sampling;SARS-CoV-2 positive;SARS-CoV-2 transmission;System;Techniques;Temperature;Test Result;Testing;Time;tissue culture;transmission process;United States Food and Drug Administration;Update;Variant;variants of concern;Viral;viral fitness;viral RNA;viral transmission;virology;Virus;Work

PROJECT_TITLE: RNA viruses of pandemic potential - viral infectivity


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Components of the epigenetic complex that regulate enhancer function and methylate histone H3 at lysine 4, including KMT2C, KMT2D, and KDM6A are early oncogenic events in urothelial cancer of the bladder and ureters, and can be detected in normal appearing urothelium. We have generated genetic engineered mouse models of urothelial cancers based on mutations of KMT2C and KMT2D. In this proposal, we will characterize the epigenetic mechanisms of tumor suppression.

PI_NAMEs: CHEN, YU  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Ablation;Affect;Allografting;allotransplant;Benign;Binding;Bladder;bladder transitional cell carcinoma;cancer invasiveness;Carcinogens;Cell Line;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clonal Expansion;combinatorial;Communication;Complex;Data;DNA;Enhancers;Epigenetic Process;Event;Exclusion;Exhibits;EZH2 gene;fitness;Functional disorder;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Engineering;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genomic Segment;Histologic;Histology;histone demethylase;Histone H3;histone methylation;histone methyltransferase;Histones;Human;immune cell infiltrate;Kidney;kinase inhibitor;KRASG12D;Lesion;Location;loss of function mutation;Lysine;Malignant neoplasm of ureter;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;men;Messenger RNA;Methyltransferase;migration;Mitogen-Activated Protein Kinase Kinases;MLL gene;Modeling;Molecular;Morbidity - disease rate;Morphology;mortality;mouse model;Mus;Muscle;Mutation;Neoplasm Metastasis;Nitrosamines;Oncogene Activation;Oncogenes;Oncogenic;Organoids;Output;Pathway interactions;Patients;Phosphotransferases;PIK3CG gene;preclinical study;Predisposition;programs;promoter;protein complex;Proteins;Recurrence;Recurrent disease;Regulation;response;Risk;RNA;Role;Sampling;Secondary to;Signal Transduction;single-cell RNA sequencing;Site;stemness;synergism;Techniques;Time;transcription factor;Transcriptional Regulation;transcriptome;Transitional Cell;Transitional Cell Carcinoma;tumor;tumor initiation;Tumor Suppression;tumorigenesis;Up-Regulation;Ureter;Urethra;Urothelial Cell;Urothelium

PROJECT_TITLE: Defining the role of histone H3K4 mono-methyltransferase dysfunction in urothelial carcinoma

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MAJUMDAR, DEVDOOT  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;American;Antibodies;Antibody Formation;Antibody titer measurement;Antigens;Biological;Cellular Immunity;Cessation of life;Clinical Research;Community Health;Coronavirus;COVID-19;COVID-19 booster;COVID-19 vaccine;Data;design;Detection;Development;Doctor of Philosophy;Dose;Encapsulated;Epitopes;Evaluation;Exhibits;falls;Foundations;Frequencies;gene therapy;Generations;global health;Goals;Grant;Humoral Immunities;Immune response;Immunization;improved;In Vitro;in vivo;Infection;Infectious Diseases Research;innovation;Kinetics;Lipid Chemistry;lipid nanoparticle;low and middle-income countries;low income country;Luciferases;manufacture;Membrane;Messenger RNA;Modality;Moderna COVID-19 vaccine;Molecular Conformation;multiple myeloma M Protein;Mus;Mutation;mutation screening;Names;neutralizing antibody;next generation;novel;novel vaccines;Nucleic Acid Vaccines;Organelles;particle;Pfizer-BioNTech COVID-19 vaccine;Population;preclinical study;prevent;Production;protective efficacy;protein expression;Proteins;Proteome;Public Health;Research;Research Project Grants;Resources;response;RNA;RNA replication;RNA vaccination;RNA vaccine;SARS-CoV-2 genome;SARS-CoV-2 immunity;Secondary Immunization;Series;Serology;SH2D3A gene;Specificity;success;System;T-Lymphocyte;Technology;Testing;timeline;tissue culture;Translations;Untranslated RNA;Vaccinated;Vaccination;vaccination strategy;vaccine acceptance;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine distribution;vaccine immunogenicity;Vaccines;Vesicle;Viral;Viral Antigens;Viral Proteins;World Health Organization

PROJECT_TITLE: Evaluation of iDMV-1.0: A Single Dose Self-Amplifying Vaccine for SARS-CoV-2


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health;Vaccine Related

PI_NAMEs: NOWAK, SARAH A (contact)

PROJECT_TERMS: Address;Adoption;Affect;analytical tool;Belief;Birth;Brazil;Case Study;Categories;Cessation of life;Child;Childhood;Communicable Diseases;Communities;COVID-19;COVID-19 misinformation;COVID-19 pandemic;critical period;Data;Decision Making;Disease;Disease Outcome;Doctor of Philosophy;experimental study;Foundations;global health;Goals;Health behavior;health belief;Immunization Programs;improved;Individual;Infectious Diseases Research;Intervention;Joints;Knowledge;Machine Learning;Misinformation;Modeling;Morbidity - disease rate;mortality;Occupations;online community;Parents;Participant;Perception;prevent;Process;Research Project Grants;Risk;Role;scaffold;smartphone application;social media;Surveys;Syphilis;Testing;Text;theories;tool;Uncertainty;United States;Vaccination;vaccination outcome;vaccine acceptance;vaccine hesitancy;vaccine safety;Vaccines;web site;Work;World Health Organization

PROJECT_TITLE: An examination of childhood vaccine hesitancy in Brazil


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_CITY: CITY OF INDUSTRY

ORG_NAME: PUBLIC HEALTH FOUNDATION ENTERPRISES

PHR: PROJECT NARRATIVE Trans people are the most severely affected by HIV yet trans people of color are particularly under-represented in science. To move the epidemic to zero new infections, zero AIDS deaths, and zero stigma, trans scientists will have to play a significant and central role in the response to HIV, especially those from under-represented racial/ethnic minority groups. This proposed SHINE Strong training program is led by under-represented minority scientists and will address this urgent need for trans HIV investigators.

PI_NAMEs: ARAYASIRIKUL, SEAN ;MCFARLAND, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advocacy;Advocate;Affect;African American;AIDS prevention;Altruism;Ancillary Study;Area;Behavior Therapy;Behavioral;Behavioral Research;Behavioral Sciences;behavioral study;Black race;burden of illness;career;Caring;Cessation of life;Cities;Clinical Sciences;cohort;college;Communities;community advisory board;cost;Country;Data;design;Development;E-learning;Education;Educational process of instructing;Epidemic;epidemic response;Equity;ethnic minority;ethnic minority population;Evidence based program;experience;faculty mentor;Food;Funding;Generations;Goals;Grant;Health;health disparity;High Prevalence;HIV;Incubators;Infection;interest;International;Intervention;Intervention Trial;Lead;Leadership;Lesbian Gay Bisexual;Lesbian Gay Bisexual Transgender;Medical;member;Mentors;Mentorship;minority scientist;minority undergraduate;Modality;Motion;Participant;Pathway interactions;peer;people of color;Persons;Phase;Play;Policies;Population;population based;population health;Positioning Attribute;power analysis;programs;psychologic;Public Health;racial minority;racial minority population;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;response;Risk;Role;Running;Sample Size;San Francisco;Schedule;Science;Scientist;serosurvey;skill acquisition;social science research;social stigma;Social support;Students;success;summer research;Support System;Time;Training;Training Programs;Training Support;transgender;transgender women;Trauma;Travel;Twin Multiple Birth;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Vision;Woman;Work

PROJECT_TITLE: SHINE Strong: Building the pipeline of HIV behavioral scientists with expertise in trans population health


NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE The fundamental biology of tissue maintenance and homeostasis directly relates to public health because our tissues are in constant interaction with our environment and respond in healthy and pathological ways. We reasonably understand the cells and molecules involved in tissue maintenance and repair, yet we do not know how they work in complex communities and networks to preserve a healthy state. The work outlined in this proposal aims to understand the fundamental biology of signaling that controls cell fate during tissue renewal and identify new avenues for therapeutic intervention.

PI_NAMEs: THORNE, CURTIS ANDREW (contact)

PROJECT_TERMS: Behavior;Biology;cell behavior;Cell Fate Control;Cells;Communities;Complex;Disease;Environment;Epithelium;Equilibrium;Gatekeeping;Genes;Goals;Homeostasis;human tissue;Maintenance;Maps;Measures;Mediator;Modeling;novel;Organoids;Outcome;Pathologic;Phosphotransferases;Physiological;Play;preservation;Proliferating;Protein Kinase;Public Health;Quantitative Microscopy;regenerative;regenerative tissue;Regulation;repaired;Research;RNA Splicing;Role;Signal Transduction;stem cell fate;stem cell niche;stem cells;stemness;System;targeted treatment;Therapeutic Intervention;tissue regeneration;Tissues;transcriptome;Work

PROJECT_TITLE: Defining signaling networks in epithelial homeostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Understanding the biological underpinnings leading to sex differences observed in heritable human diseases is critical for developing precision medicine approaches that work equally well in males and females. Equally as important are gender-related exposures including socioeconomic position and sexual assault-trauma which have tremendous and widespread effects on disease risk throughout the lifespan. This proposal aims to create new knowledge of how sex and gender-related exposures impact disease and how they modify genetic risk for disease across the entire medical phenome, including over 1,000 clinically relevant biomarkers.

PI_NAMEs: DAVIS, LEA K (contact);STRANGER, BARBARA E

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Academic Medical Centers;Age of Onset;Awareness;biobank;Biological;Biological Markers;Blood Glucose;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Clinical;clinically actionable;clinically relevant;cohort;comorbidity;Complex;Computerized Medical Record;Data;Development;Diagnosis;diagnostic biomarker;Disclosure;Disease;Disease Outcome;disorder risk;Electronic Health Record;Electronic Medical Records and Genomics Network;Female;Gender;Genes;Genetic;genetic architecture;Genetic Diseases;genetic epidemiology;Genetic Risk;genome wide association study;genome-wide;Genomic medicine;Genomics;Genotype;Genotype-Tissue Expression Project;genotypic sex;Goals;Gynecologic;Health;Heritability;Human;human disease;Incidence;Infrastructure;Knowledge;Laboratories;Lead;Letters;life span;Link;Lipids;Major Depressive Disorder;male;Medical;Medical Records;Medicine;Mental disorders;National Human Genome Research Institute;Obesity;Outcome;Pain;Patients;personalized approach;Pharmaceutical Preparations;phenome;Polycystic Ovary Syndrome;polygenic risk score;Population;Poverty;precision medicine;Prevalence;Procedures;psychosocial;Records;Regulation;Research;Research Personnel;Resources;Risk;Risk Factors;Sampling;Sensitivity and Specificity;Severities;sex;Sex Bias;Sex Differences;Sex Differentiation;sexual assault;Site;Socioeconomic Status;Substance abuse problem;success;Symptoms;Testing;Testosterone;Training;trait;Trauma;White Blood Cell Count procedure;Work

PROJECT_TITLE: Elucidating the phenome-wide impact of sex and gender on disease


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention;Skin Cancer

ORG_DEPT: DERMATOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The majority of melanomas diagnosed and treated in the US are in early stages, and a significant percentage exhibit a high potential for metastasis. Research on early disease has been limited due to lack of appropriate model systems and relevant human tissues. In this proposal, by overcoming prior limitations through innovation, we will study the determinants of the tumor and the host during non-aggressive to aggressive progression in early disease.

PI_NAMEs: HERLYN, MEENHARD F;SCHOBER, MARKUS  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: 3-Dimensional;advanced system;Alleles;Animals;antagonist;anti-CD20;anti-tumor immune response;Antitumor Response;Autologous;B-Lymphocytes;Basic Science;Behavior;Biological;Biological Markers;Biological Models;Biology;CD34 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Lineage;Cells;Clinical;Clinical Data;clinical practice;cohort;Data Set;Dermal;Development;Diagnosis;Differentiation Antigens;Disease;Disease Outcome;Disease Progression;draining lymph node;Epigenetic Process;Etiology;Exhibits;Experimental Models;Failure;Fetal Liver;Future;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Genome;Goals;Growth;Hematopoietic stem cells;HLA-A gene;Host Defense Mechanism;Human;human data;human model;human tissue;humanized mouse;Immune;immune cell infiltrate;Immune response;Immune signaling;Immune system;immunodeficiency;Immunohistochemistry;Immunological Models;immunoregulation;Implant;In Vitro;in vivo;in vivo Model;Innate Immune Response;innovation;Interferons;Invaded;irradiation;Macrophage;Malignant - descriptor;Malignant Neoplasms;malignant state;melanocyte;Melanoma;Melanoma Cell;Melanoma patient;Modeling;Molecular;mouse model;Mus;Mutation;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Organ;pathogen;Pathway interactions;Patients;Phase;Phenotype;potential biomarker;predictive marker;prevent;Prevention strategy;Prognosis;prognostic;prognostic assays;prognostication;Proteins;Radial;reconstitution;Reproducibility;Research;Role;Signal Pathway;Signal Transduction;Skin;Stimulator of Interferon Genes;STING agonists;survival prediction;System;Techniques;Testing;Thick;Thymic Tissue;Time;Tissue Sample;transcriptome;tumor;tumor growth;tumor progression;tumor-immune system interactions;ultraviolet;Ultraviolet B Radiation;Validation;Work

PROJECT_TITLE: Dissecting Phenotype Switching in Early Stage Melanomas


ORG_CITY: Boulder

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE HIV remains the most consequential zoonosis of the last century, with 36 million fatalities and another 37 million infected. Even today, almost 2,000 people per day die of HIV/AIDS globally. We are developing a new model organism that will facilitate better and faster development of HIV vaccines.

PI_NAMEs: SAWYER, SARA  (contact)

PROGRAM_OFFICER_NAME: DANG, QUE

PROJECT_TERMS: acute infection;Animal Model;cross immunity;Development;HIV;HIV Infections;HIV vaccine;HIV-1;HIV/AIDS;Human body;Immune;Macaca;model organism;Modeling;Monkeys;pandemic disease;Persons;Pharmaceutical Preparations;Primates;System;Testing;tool;vaccine candidate;vaccine development;Vaccines;Viral reservoir;viral transmission;Virus Latency

PROJECT_TITLE: Breaking the Barrier to an HIV Vaccine


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: MONTEFIORE MEDICAL CENTER (BRONX, NY)

PHR: The goal of the Montefiore-Einstein Minority/Underserved National Community Oncology Research Program (MU NCORP) is to advance the prevention, diagnosis, treatment, and management of early and advanced cancer. Our goals are to: 1) accrue at least 80 subjects to trials sponsored by the NCORP research bases (including at least 40 to therapeutic trials), 2) provide scientific and administrative leadership to the ECOG-ACRIN, NRG and Alliance research bases; 3) expand our capacity for cancer care delivery research (CCDR) to include at least 3 active CCDR protocols; 4) train and mentor young investigators in all areas of NCORP research; and 5) contribute expertise in novel methodology to address cancer health disparities, including patient engagement, trial design and outcomes measurement.

PI_NAMEs: HALMOS, BALAZS  (contact);OHRI, NITIN ;RAPKIN, BRUCE D

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Academic Medical Centers;Address;Adjuvant;Adjuvant Study;Advanced Malignant Neoplasm;Aftercare;Albert Einstein Cancer Center;American College of Radiology Imaging Network;Anal carcinoma;anti-cancer research;Area;base;Biological Markers;biomarker validation;Black race;black women;Breast Cancer Detection;cancer care;Cancer Center;cancer clinical trial;Cancer Control;cancer health disparity;cancer imaging;Cancer Patient;cancer prevention;cancer therapy;care delivery;career;Clinical;Clinical Research;Collection;college;Committee Members;Communities;Community Clinical Oncology Program;County;Coupled;Diagnosis;Doctor of Philosophy;Eastern Cooperative Oncology Group;Ethnic Origin;Evaluation;experience;Faculty;federal poverty level;financial toxicity;Foundations;Funding;Goals;health care delivery;health related quality of life;Health system;Hematopoietic Neoplasms;Hispanic;Home;Infrastructure;innovation;Institution;institutional capacity;Language;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Medical center;Medicine;member;Mentored Clinical Scientist Development Program;Mentors;Methodology;Methods;Minority;minority engagement;Minority Groups;Minority Participation;minority patient;minority subjects;Mission;Morbidity - disease rate;mortality;NCI-Designated Cancer Center;Neuropathy;New York;Nivolumab;novel;oncology program;Outcome;Outcomes Research;Patient Care;patient engagement;Patients;Pilot Projects;population based;postgraduate education;precision medicine;Prevention;programs;prospective;Protocols documentation;Recording of previous events;Research;Research Personnel;Resources;Role;Science;screening;Site;success;System;taxane;team-based care;Therapeutic;Therapeutic Trials;Training;Training and Education;Training Programs;Training Support;Translational Research;treatment trial;trial design;trial planning;Underrepresented Minority;underserved community;underserved minority;United States;Urban Community

PROJECT_TITLE: MINORITY-BASED COMMUNITY ONCOLOGY PROGRAM


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative One of the most challenging aspects of cancer treatment is the identification of therapies that kill cancer cells, but not healthy tissue. We have found that tumor cells co-opt an energy generation system from human sperm, which is otherwise not found in adult tissues. By studying this mechanism in detail, we will be able to identify a new therapeutic entry point for selectively starving cancer cells of energy while leaving normal tissues unaffected.

PI_NAMEs: WHITEHURST, ANGELIQUE WRIGHT (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adopted;Adult;Aneuploidy;Animals;Antigens;Attenuated;Behavior;Biological;cancer cell;cancer therapy;cancer/testis antigen;Cell Death Signaling Process;Cell Survival;Cells;Characteristics;complex IV;cytochrome c oxidase;Data;design;Development;Dimensions;DNA;DNA Damage;Electron Transport;Environment;female reproductive tract;Gene Expression;gene product;Generations;Genes;Glycolysis;Growth;Human;Hypoxia;In Vitro;in vivo;Individual;inhibitor;innovation;Knowledge;Length;Lung;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Messenger RNA;Metabolic;Metastatic Neoplasm to the Lung;Mitochondria;Modality;Modeling;Molecular;Motility;mRNA Expression;neoplastic cell;Normal tissue morphology;novel;novel therapeutics;Outcome;Ovary;Oxidases;Oxidative Phosphorylation;Oxygen;Patients;Phenotype;Physiology;Placenta;Post-Translational Protein Processing;preservation;Process;Production;programs;Proliferating;protein expression;Protein Isoforms;Proteins;Sampling;selective expression;Sequence Alignment;Signal Transduction;Specificity;sperm cell;Sperm Motility;Starvation;Structural Models;Structure;Structure of parenchyma of lung;success;System;Testing;Testis;Therapeutic;Therapeutic Index;therapeutic target;Time;Tissues;tumor;tumor growth;tumor hypoxia;tumor microenvironment;Tumor Tissue;tumor xenograft;tumorigenesis;tumorigenic;Work;Xenograft procedure

PROJECT_TITLE: The sperm specific protein, COX6B2, promotes metabolic reprogramming in lung adenocarcinoma

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: We aim to unravel the driving mechanisms and identify potential therapeutic targets underlying lung sequelae post-acute COVID-19. Additionally, we will establish a mouse model to validate predictive biomarkers and/or therapeutic targets of lung sequelae post-acute COVID-19. The successful completion of the study will generate unprecedented insights on clinical, viral and immune traits of pulmonary sequelae, and will identify key causal immune mechanisms and therapeutic targets against chronic lung diseases post-acute COVID-19.

PI_NAMEs: SUN, JIE  (contact);VASSALLO, ROBERT

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;Acute Disease;Address;Adult;Age Years;aged;aging population;Animal Model;Automobile Driving;Blood;Bronchoalveolar Lavage Fluid;CD8-Positive T-Lymphocytes;CD8B1 gene;Characteristics;chest computed tomography;Chronic;Chronic lung disease;Chronic Lung Injury;Clinical;clinical examination;Clinical Research;cohort;COVID-19;COVID-19 sequelae;data integration;Development;druggable target;Dyspnea;Enrollment;Exertion;Exhibits;Fatigue;Fibrosis;follow-up;Future;Goals;high risk;Hospitalization;Human;Human Characteristics;human data;Hypoxia;Immune;Immune response;Immunology;Impairment;Individual;Infection;insight;Intervention;Link;Long COVID;long-term sequelae;Longitudinal cohort;Lung;Lung immune response;Memory;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;new therapeutic target;pandemic disease;pathogen;Pathologic;Patients;Physiological;Population;Population Control;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;predictive marker;preventive intervention;pulmonary function;Pulmonary function tests;Resolution;respiratory;Respiratory Signs and Symptoms;response;Role;Sample Size;SARS-CoV-2 infection;Science;Shortness of Breath;Study models;Survivors;System;Systems Biology;T cell response;T-Lymphocyte Subsets;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;tissue resident memory T cell;Tissues;tool;trait;Validation;Viral;Viral reservoir;X-Ray Computed Tomography

PROJECT_TITLE: Uncover mechanisms underlying the development of chronic lung sequelae post COVID-19

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative In lung conditions, such as smoking-related chronic bronchitis, the airways have an abnormally increased mucus production and reduced ability to get it out of the respiratory system. A progression of this process leads to the accumulation of mucus and ultimately plug formation that blocks the airways. We will score mucus plugging in the airways using chest computed tomography images and assess the associations between imaging-detected mucus plugging and respiratory symptoms and future airway disease.

PI_NAMEs: DIAZ, ALEJANDRO  (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Adult;Affect;Air;Air Pollution;Airway Disease;Biological;Biology;bronchial mucus;Bronchitis;cardiorespiratory fitness;Cause of Death;Cells;chest computed tomography;Chronic;Chronic Bronchitis;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;cigarette smoke-induced;Clinical;clinical care;clinical heterogeneity;clinically relevant;cohort;Cohort Studies;community living;Coronary Artery Risk Development in Young Adults Study;Coughing;Cross-Sectional Studies;Data;diagnostic criteria;Diameter;Disease;disorder risk;Environmental Epidemiology;Exposure to;fitness;follow-up;Forced expiratory volume function;Framingham Heart Study;Functional disorder;Future;Genetic;Genetic Predisposition to Disease;genetic variant;genome sequencing;genome-wide;Hospitalization;Image;imaging detection;Impairment;Individual;insight;Intercept;life span;Logistics;longitudinal analysis;Lung;lung health;lung imaging;Marijuana;Marijuana Smoking;marijuana use;mortality;Mucous body substance;mucus clearance;mucus hypersecretion;Particulate Matter;Pathologic;Patients;Pattern;persistent symptom;Persons;Phenotype;Play;Population;Population Study;Predisposition;Prevalence;prevent;Prevention;Prevention strategy;Primary Care;Process;Production;protective factors;Public Health;pulmonary function;Pulmonology;rare variant;Reporting;Reproducibility;resilience;Respiratory Signs and Symptoms;Respiratory System;Risk;Risk Factors;Role;Scanning;Smoker;Smoking;Symptoms;Testing;TP53 gene;Trans-Omics for Precision Medicine;treatment strategy;whole genome;Work;X-Ray Computed Tomography

PROJECT_TITLE: Understanding airway mucus dysfunction in population-based studies

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: WASHINGTON

ORG_NAME: INTERNATIONAL BROTHERHOOD OF TEAMSTERS

ORG_STATE: DC

PHR: Principal Investigator/Program Director (Last, First, Middle): Byrd, Lamont FOA Number RFA-ES-19-004 Project Narrative (DOEWTP) The IBT Consortium represents and has ready access to thousands of workers throughout the DOE Nuclear Weapons Complex who remediate hazardous waste sites, transport hazardous wastes, handle, package, transport and warehouse hazardous materials, and respond to hazardous materials releases. The IBT Consortium is staffed by a team of highly experienced worker health and safety training experts who specialize in industrial hygiene, curriculum development, adult education techniques, information technology, and craft-experienced worker-trainers. The combination of access to worker populations and institutional capacities enables the IBT Consortium to deliver high quality model training that complies with the NIEHS Minimum Criteria, applicable standards and regulations as promulgated by the Department of Energy (DOE), Environmental Protection Agency (EPA), Occupational Safety and Health Administration (OSHA), and the Department of Homeland Security (DHS). IBT Consortium Page 1 Project Narrative (DOEWTP)

PI_NAMEs: AUSTIN, CHARLES  (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Academy;Accidents;Address;Adult;building materials;Communities;community organizations;Competence;Complex;curriculum development;Department of Energy;Educational Technics;Electronic Mail;Emergency response;Emergency Situation;Employee;Employment;Environment;experience;Fire - disasters;Funding;Grant;Hazardous Substances;Hazardous Waste;Hazardous Waste Sites;Health;Hour;Industrial Health;Information Technology;Infrastructure;institutional capacity;International;Louisiana;member;Modeling;Names;National Institute of Environmental Health Sciences;neighborhood safety;Nuclear Weapon;Occupations;Population;Principal Investigator;programs;Radioactive;Radioactive Waste;Radiology Specialty;Regulation;remediation;repaired;resilience;Safety;Security;Site;Soil;Target Populations;Telephone;Training;Training Programs;Transportation;U-Series Cooperative Agreements;United States Environmental Protection Agency;United States Occupational Safety and Health Administration;Washington;web site;Work;worker safety;Workplace

PROJECT_TITLE: International Brotherhood of Teamsters HAZMAT Training at DOE Nuclear Weapons Complex


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Genetics;Health Services;Prevention;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Lynch syndrome is caused by defective DNA repair related to one of four genes, each associated with varying risks of colorectal cancer. In this proposal, we will determine optimal, risk-tailored surveillance strategies by genotype to minimize unnecessary screening tests and reduce overtreatment. These results will allow for broader insights into cancer prevention and control based on genomic data for the advancement of precision medicine initiatives.

PI_NAMEs: HUR, CHIN  (contact);KASTRINOS, FAY

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Acceleration;Address;Adherence;Affect;Age;Area;Attitude;autosome;Award;cancer care;Cancer Control;Cancer Model;cancer prevention;Clinical;cohort;Collaborations;Colonoscopy;Colorectal Adenocarcinoma;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;comorbidity;cost effectiveness;Cost Savings;Deimplementation;Development;DNA;DNA Repair;Effectiveness;Feces;Focus Groups;Foundations;Gender;gene repair;Genes;genetic variant;genomic data;Genotype;Germ Lines;Goals;Guidelines;Health;Health Personnel;Hereditary Breast and Ovarian Cancer Syndrome;Hereditary Nonpolyposis Colorectal Neoplasms;high risk;Hybrids;improved;improved outcome;Incidence;Individual;Inherited;insight;Interdisciplinary Study;lifetime risk;Malignant Neoplasms;Methodology;Mismatch Repair;MLH1 gene;Modality;Modeling;models and simulation;mortality;MSH2 gene;MSH6 gene;mutation carrier;novel;Outcome;overtreatment;Pathogenicity;Patient risk;Patients;PMS2 gene;Polyps;Precision Medicine Initiative;prevent;Provider;Quality of life;Recommendation;Regimen;Research;Resources;Risk;Risk Estimate;Risk Factors;risk stratification;screening;surveillance strategy;Surveys;Syndrome;Testing

PROJECT_TITLE: Optimal Colorectal Cancer Surveillance Strategy for Lynch Syndrome by Genotype

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-Z(02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Patient Safety;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: For patients with peripheral artery disease (PAD) who undergo a peripheral vascular intervention (PVI) to improve quality of life and/or prevent limb loss, there are evidence based, guideline-directed medical therapies that should be prescribed after the intervention. However, adherence to these therapies remain poor among this population of patients, placing them at an increased risk of limb loss, cardiovascular disease, and death. The proposed work leverages complementary methods in qualitative research, implementation science, and clinical trial design to examine the barriers to medication adherence and evaluate a potential tool that may facilitate improved communication between the clinic provider and patient about how to improve adherence to these therapies in patients with PAD who have undergone PVI.

PI_NAMEs: RYMER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;adherence rate;Affect;Ambulatory Care Facilities;American;Amputation;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Antiplatelet Drugs;Aspirin;Award;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career development;Caring;Cessation of life;Characteristics;Chronic Disease;claudication;Clinic;Clinical;Clinical Research;Clinical Trials Design;clopidogrel;cohort;Communication;comorbidity;Competence;Complex;cost;Data;design;Development;effectiveness testing;efficacy outcomes;Electronic Health Record;Ensure;Environment;Ethnic Origin;Event;evidence base;experience;Feedback;Foundations;Future;Gangrene;Goals;Guidelines;Health;Health Care Costs;health care service utilization;health literacy;Health system;high risk;implementation science;implementation strategy;implementation tool;improved;Information Technology;inhibitor;instrument;Intervention;intervention effect;Interview;K-Series Research Career Programs;leadership development;Leg Ulcer;limb loss;Limb structure;low health literacy;Lower Extremity;Measurement;Medical;medication compliance;meetings;Mentors;Methodology;Methods;mortality;Myocardial Infarction;Needs Assessment;Nurses;Outcome;Outpatients;Patient Compliance;patient oriented;patient population;Patient Selection;Patients;Performance;Peripheral;Peripheral arterial disease;Persons;Pharmaceutical Preparations;Pharmacy facility;prevent;primary outcome;Process;Program Development;Provider;Qualitative Research;Quality of life;Race;Randomized;Randomized, Controlled Trials;Regimen;Reporting;Research;Research Personnel;Risk;Risk Reduction;secondary outcome;sex;Site;skills;socioeconomics;Structure;Symptoms;Testing;therapy design;tool;Training;treatment as usual;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Implementation of a Medication Adherence Instrument among Patients with Symptomatic Peripheral Artery Disease after Peripheral Vascular Intervention

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Natural Killer (NK) cell-mediated antibody dependent cellular cytotoxicity (ADCC) is correlated with delayed progression of HIV disease, but exactly how antibodies regulate ADCC activity through immune complexes is not well-understood. This project will illuminate how the molecular nature of antibody binding to HIV influences NK cell ADCC activity by utilizing cutting-edge fluorescence microscopy to examine antibody receptors at the synapse between NK cells and their targets. The data from this project will form guiding principles to engineer HIV antibody therapeutics and vaccines aimed at eliciting more potent ADCC activity, with potential long-term applications to other human viruses and diseases.

PI_NAMEs: MURIN, CHARLES DANIEL (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: 3-Dimensional;Activated Natural Killer Cell;Affect;Antibodies;antibody engineering;antibody-dependent cell cytotoxicity;Antigen-Antibody Complex;arm;Binding;biophysical properties;Biophysics;Cell Death;Cell surface;Cells;Color;Complement;Complex;Data;design;Disease;Engineering;Epitopes;Fab Immunoglobulins;Fc Receptor;FCGR3A gene;fluorescence lifetime imaging;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;geometric structure;Geometry;Goals;Health;HIV;HIV Antibodies;HIV envelope protein;HIV Receptors;Human;human disease;IgG Receptors;Immunoglobulin G;immunological synapse;immunological synapse formation;improved;In Vitro;in vivo;innovation;insight;Kinetics;Knowledge;Location;Measurement;Measures;Mediating;Microscopy;millisecond;Molecular;molecular mechanics;Movement;nanoscale;Nanoscopy;Natural Killer Cells;Nature;neutralizing antibody;novel strategies;Outcome;pathogenic virus;Permeability;permissiveness;Pharmaceutical Preparations;Phosphotransferases;receptor;recruit;Research;Resolution;Signal Transduction;single molecule;spatiotemporal;Surveys;Synapses;Techniques;Testing;Therapeutic;Therapeutic antibodies;therapeutic target;ultra high resolution;Vaccines;Variant;Virus;Work;ZAP-70 Gene

PROJECT_TITLE: HIV antibodies and NK cell ADCC: nanometer-scale tracking of immune synapse dynamics.

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative The mitochondrial protein unfoldase CLPX tunes mitochondrial activity by its selection of protein substrates to unfold and to degrade with its partner protease CLPP. Mutations or misregulation of CLPX and CLPP cause mitochondriopathies, including neurological and blood disorders and drive progression in multiple cancers. Our studies will reveal mechanisms by which CLPX conditionally selects its substrates at the appropriate time or condition, thus describing molecular bases of disease and providing therapeutic targets.

PI_NAMEs: KARDON, JULIA R. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adaptor Signaling Protein;Affect;base;Binding;Binding Sites;Biochemical;Biological Assay;Cell Culture Techniques;Cells;Clinical Trials;Coenzyme A;cofactor;Complex;Coupled;Data;Defect;Detection;Disease;disulfide bond;Drug Targeting;Electrons;Environment;Enzymes;Equilibrium;Eukaryotic Cell;Family member;Fatty Acids;Feedback;Goals;Growth and Development function;Hematological Disease;Heme;heme a;heme biosynthesis;Heme Iron;Human;Human Activities;in vitro Assay;Kinetics;Licensing;Ligands;Ligase;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Methods;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Conformation;Molecular Target;Mus;Mutation;N-terminal;Nature;Negative Finding;Nervous System Disorder;Outcome;Oxygen;Pathway interactions;Peptide Hydrolases;Peptides;Phenotype;Physiology;Process;Productivity;programs;Protein Engineering;Protein Family;protein function;Protein Truncation;Proteins;Proteome;Proteomics;reconstitution;Repression;response;Roentgen Rays;Role;Shapes;Signal Transduction;Site;Spectrum Analysis;Structure;System;Testing;therapeutic target;therapy development;Time;tool;tumor progression;unfoldase;Variant

PROJECT_TITLE: Dynamic control of mitochondrial function by the protein unfoldase CLPX

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Previous research studies have shown that there are racial differences in immunotherapy outcomes for colorectal cancer. With the aid of a specially developed mouse model, tumor progression and immunity differences between patients with African American ancestry and Caucasian ancestry will be studied for this cancer. This project is relevant to public health and the research mission of the National Cancer Institute because we expect to lay a solid foundation for more effective immune-based therapies focused on African American patients with colorectal cancer.

PI_NAMEs: CAMP, ERNEST RAMSAY;RUBINSTEIN, MARK P (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: adenoma;African American;Agonist;American;anti-PD1 therapy;Autologous;Automobile Driving;Biological;Biological Markers;black patient;Black Populations;Cancer Etiology;cancer health disparity;cancer imaging;cancer infiltrating T cells;Caucasians;CD8-Positive T-Lymphocytes;CD8B1 gene;Cellular biology;Cessation of life;chemotherapy;clinical practice;clinically relevant;colon cancer patients;Colorectal Cancer;Combination Drug Therapy;Complex;Cytokeratin;cytokine;Data;Death Rate;design;Development;Disease;Disparity;Engineering;Engraftment;Exhibits;Flow Cytometry;Fluorouracil;Foundations;Frequencies;Future;Genetic;Goals;Human;imaging capabilities;imaging study;Immune;immune activation;immune cell infiltrate;Immune response;Immuno-Chemotherapy;Immunocompetent;Immunologics;Immunologist;Immunotherapy;improved;Incidence;Inflammatory;Interferon Type II;Interleukin-15;Laboratory Finding;Malignant Neoplasms;Mediating;MHC Class I Genes;Mission;Modeling;mortality;mouse model;multidisciplinary;Mus;National Cancer Institute;Natural Killer Cells;novel;Oncology;Outcome;oxaliplatin;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Positioning Attribute;premalignant;prevent;Process;programmed cell death ligand 1;programs;Public Health;Publishing;Race;racial difference;racial disparity;Research;Research Personnel;research study;Resected;response;Role;Sampling;Scientist;Secondary to;Solid;spectrograph;Surgeon;Survival Rate;synergism;T cell clonality;T cell infiltration;T cell receptor repertoire sequencing;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;therapy resistant;Translating;treatment response;tumor;Tumor Antigens;Tumor Escape;Tumor Immunity;tumor progression;Work

PROJECT_TITLE: Defining the role of tumoral MHC Class I Expression in Mediating Colorectal Cancer Racial Disparities

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: We have established ‘The Chicago Clinical Center’ for Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC), bringing together multi-disciplinary team members from major academic centers located in Cook County, one of the most populous, racially and ethnically diverse counties in the United States to help the Consortium to build a diverse clinical cohort. In addition, we propose studies to define the contribution of diet enriched in animal protein and fat and low in fiber, through its interaction with the gut microbiota, to development of diabetes, especially type 1 diabetes following acute pancreatitis. Improving our understanding of these relationships can help to identify novel biomarkers for acute pancreatitis and diabetes that are applicable to general population and to develop effective preventive and treatment strategies.

PI_NAMEs: LAYDEN, BRIAN THOMAS;YAZICI, CEMAL  (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: acute pancreatitis;African American;African American population;Animals;Autoimmune;B-Lymphocytes;Bacteria;Cell Physiology;Chicago;Clinical;clinical center;cohort;Consumption;cooking;Country;County;Data;Data Correlations;Data Set;defined contribution;Development;Diabetes Mellitus;Diet;dietary;Dietary Fiber;Disease;Endocrine;Energy-Generating Resources;Environment;Environmental Risk Factor;ethnic diversity;Etiology;Fatty acid glycerol esters;Feces;Fiber;General Population;Generations;Genes;Goals;gut microbiome;gut microbiota;Health Disparities Research;health disparity;high risk;Hispanic;Hispanic Populations;Hydrogen Sulfide;Immunologics;immunoregulation;improved;in vivo Model;Individual;Inflammatory;Injury;Institution;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Intake;Lead;Link;Longitudinal cohort;Measures;Meat;Mediating;Mediation;member;Metabolic;microbial;microbiome;microbiota composition;Minority Groups;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Nature;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;novel marker;Nutrient;Pancreatitis;Pathway interactions;patient population;Patients;Population Heterogeneity;Prevention strategy;Production;Proteins;racial diversity;Risk;Risk Factors;Role;Sampling;Serum;Sulfur Metabolism Pathway;Translations;treatment strategy;United States;Volatile Fatty Acids

PROJECT_TITLE: Mechanisms of diabetes from acute pancreatitis in African Americans and Hispanics


NIH_SPENDING_CATS: Genetics;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative The essential mechanosensitive channels PIEZO1 and PIEZO2 have been tightly linked to multiple channelopathies, however, the underlying mechanisms of PIEZO diseases remain largely unknown. My previous work identified that disruption of pezo-1, the sole ortholog of PIEZO in C. elegans, caused a reduced brood size, which could be used as a readout for genetic suppressor screens to identify molecular pathways or determinants that suppress or reverse these defects. The goal of this research is to identify new genetic interactors and signaling pathways of PEZO-1 that suppress the defective reproduction phenotypes caused by PIEZO disease alleles, which may serve as a basis for other studies investigating PIEZO function and shed light on the potential for novel therapeutical drug target design.

PI_NAMEs: BAI, XIAOFEI  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Affect;Alleles;Animal Model;Arthrogryposis;Award;Basic Science;Biochemical;Biological Assay;Biological Process;Caenorhabditis elegans;Calcium;Calcium Signaling;Cardiovascular system;career;Cells;Connective Tissue;Data;Defect;Dehydration;design;Development;Disease;Distal;Drosophila genus;Drug Targeting;Dysplasia;egg;Electrophysiology (science);Exocytosis;Functional disorder;gene interaction;Genes;Genetic;genetic analysis;genetic approach;Genetic Predisposition to Disease;Genetic Screening;genome sequencing;Germ Lines;Goals;Gonadal Steroid Hormones;Gonadal structure;Gordon syndrome;Hermaphroditism;Homeostasis;Homologous Gene;Human;Image;in vivo;Inherited;Ion Channel Protein;Knowledge;Link;Mass Spectrum Analysis;mechanical stimulus;mechanotransduction;Membrane;Missense Mutation;Modeling;Molecular;Mus;mutant;Mutation;Nature;Nematoda;Neurons;new therapeutic target;novel;novel therapeutics;Oocytes;Orthologous Gene;Pathway interactions;Patients;Pharyngeal structure;Phenotype;Physiological;Physiological Processes;Piezo 1 ion channel;Piezo 2 ion channel;Prostaglandins;Pump;Rare Diseases;Regulation;Reproduction;Reproductive Process;Reproductive system;reproductive tract;Research;Research Personnel;Role;sensor;Series;Signal Pathway;Signal Transduction;skills;sperm cell;Sperm Motility;stomatocytic anemia;Stretching;Suppressor Mutations;Symptoms;System;Testing;Therapeutic;Tissues;trafficking;Translational Research;Variant;vestibular system;whole genome;Work;Zebrafish

PROJECT_TITLE: Modeling PIEZO associated diseases in Caenorhabditis elegans: from genetics to mechanism

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Mental Health;Pain Research;Palliative Care;Rehabilitation

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Meaning-Centered Psychotherapy (MCP), developed by Breitbart and colleagues at Memorial Sloan Kettering Cancer Center, is the only empirically-supported treatment that has clearly demonstrated efficacy in improving quality of life and spiritual well-being and in alleviating existential distress, loss of meaning, despair, and physical symptom burden distress in patients with advanced cancer. As a result, there has been overwhelming demand for MCP training from multidisciplinary palliative and cancer care clinicians across settings. The continuation of this R25-supported (R25CA190169; P.I. W. Breitbart) research education program in MCP intervention skills will address a critical growing need to train clinicians in evidence-based interventions and to disseminate MCP to advanced cancer patients in need of effective psychosocial care.

PI_NAMEs: BREITBART, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Active Learning;Address;Adoption;Advanced Malignant Neoplasm;Attention;Award;cancer care;Cancer Education Grant Program;Cancer Patient;cancer therapy;care providers;care systems;Cessation of life;Clinical;clinical practice;Communication;Communities;coping;Counseling;Data;Data Collection;Discipline;Dissemination and Implementation;Distress;education research;effective intervention;end of life care;Ensure;Evaluation;Event;evidence base;Evidence based intervention;Faculty;Feeling hopeless;follow-up;Funding;Goals;implementation facilitation;improved;innovation;Institution;interest;International;Intervention;intervention program;Learning;Maintenance;Manuals;Medical;Memorial Sloan-Kettering Cancer Center;Mental Depression;Methodology;Modeling;multidisciplinary;multimodality;National Cancer Institute;novel;Oncology;Palliative Care;Participant;Patients;physical symptom;Play;programs;psychologic;Psychological reinforcement;psychosocial;Psychosocial Assessment and Care;Psychotherapy;Qualifying;Quality of life;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Institute;Role;satisfaction;skill acquisition;skills;Spiritual well-being;Spirituality;success;Symptom Burden;Testing;Time;Training;Training Programs;Translations;United States National Institutes of Health;Waiting Lists;webinar

PROJECT_TITLE: Meaning-Centered Psychotherapy Training Program for Cancer Care Clinicians

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: To maintain skin barrier function epidermal keratinocytes undergo differentiation during which the gene expression programs switch from maintenance of cell proliferation to terminal differentiation. In addition, skin homeostasis relies on cytokines, deregulation of which may lead to psoriasis that affects 2%-3% people worldwide. In the current application, we will functionally interrogate FOXQ1, a novel regulator of keratinocyte differentiation and psoriasis-like phenotypes.

PI_NAMEs: NIKIFOROV, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Affect;Atopic Dermatitis;Automobile Driving;Biological;Calcineurin;Calcium;Cell Maintenance;Cell Proliferation;Cells;Chemicals;cofactor;constitutive expression;cytokine;Dehydration;Differentiation Antigens;Disease;Epidermis;Equilibrium;Event;extracellular;FOXQ1 gene;Gene Expression;gene repression;Genes;Genetic Transcription;Histone Deacetylase;histone demethylase;Homeostasis;Human;Hyperplasia;Imiquimod;Impairment;in vivo;Inflammatory;intercellular communication;interleukin-22;keratinocyte;keratinocyte differentiation;Knock-out;Knockout Mice;Large Keratinocyte;Lesion;Mediating;member;Messenger RNA;Mus;novel;overexpression;Pattern;Persons;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Prevention;Process;programs;Proliferating;Protein Dephosphorylation;Protein Family;Proteins;Psoriasis;Regulation;response;Role;Signal Transduction;Skin;skin barrier;skin disorder;STAT3 gene;Testing;transcription factor;Transcriptional Regulation;treatment response;Wild Type Mouse

PROJECT_TITLE: Bidirectional control of keratinocyte differentiation and proliferation by transcription factor FOXQ1

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Dilated cardiomyopathy (DCM) is a common and deadly form of genetic heart disease that is often caused by mutations in proteins that comprise structural networks in the cytoskeleton of heart cells (cardiomyocytes), and current treatment options for patients with DCM only delay its progression without addressing the underlying mechanisms. These mutations likely cause disruptions in the way cardiomyocytes sense and distribute mechanical forces generated from the contractile apparatus in the cell and/or mechanical cues from extracellular stimuli, but the role of these mechanosignaling pathways in DCM progression remains unknown. The research I propose here will employ gene-edited murine and human cardiomyocytes that express DCM-causing defects in the cytoskeletal protein Filamin C, which will be used in computational and experimental approaches designed to reveal how Filamin C regulates subcellular structure, the transmission and distribution of intracellular forces, and mechanically triggered gene expression of hypertrophic biomarkers in the cell, with the long-term goal of discovering novel treatments that can prevent or attenuate mechanically induced pathological remodeling in the heart.

PI_NAMEs: POWERS, JOSEPH D. (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Atomic Force Microscopy;Attenuated;Biological Markers;biomechanical test;biophysical techniques;Biophysics;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Clinical;Cytoskeletal Proteins;Cytoskeleton;Defect;design;Development;Diagnosis;Diastole;Dilated Cardiomyopathy;Equilibrium;extracellular;Extracellular Matrix;Fibroblasts;filamin;Fluorescence Resonance Energy Transfer;Frameshift Mutation;Functional disorder;functional loss;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Targeting;Genes;Genetic;Geometry;Goals;Heart;heart cell;Heart Diseases;Heart failure;Heterozygote;Homologous Gene;Human;human induced pluripotent stem cells;Human Pathology;Hypertrophy;Image;In Vitro;in vitro Model;induced pluripotent stem cell derived cardiomyocytes;Investigation;Knock-out;Knockout Mice;Length;Life;Link;loss of function mutation;Maintenance;Measurement;mechanical force;mechanical load;mechanical signal;mechanical stimulus;Mechanics;Mediating;Mentors;Microfilaments;Modeling;Molecular;mouse model;multi-scale modeling;Mus;Mutation;Myocardium;Nonsense Mutation;novel;novel therapeutics;Pathogenicity;Pathologic;Pathway interactions;Patients;Phase;Phenotype;Play;post-doctoral training;prevent;Proteins;Reporting;Research;response;Role;Sarcomeres;sensor;Signal Pathway;Stimulus;Stress;Structural defect;Structure;Subcellular structure;Systole;Techniques;Testing;Tissues;tool;transcriptomics;Translating;transmission process;Variant;Ventricular;ventricular hypertrophy;Ventricular Remodeling;X ray diffraction analysis

PROJECT_TITLE: Dysregulated mechanosignaling in dilated cardiomyopathy caused by defective Filamin C


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Patient Safety;Precision Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE The proposed research will provide novel Bayesian models and clinical trial designs for developing and evaluating biological treatments, including cell therapies, immunotherapies, and targeted agents accounting for complex clinical and biological outcomes and multidimensional treatment e ects that may vary with disease subtypes and patient subgroups. The aims are to develop and identify optimal biotherapy-schedule-dose combinations tailored to individual patient characteristics, compare biotherapies for each of a variety of di erent cancers and therapeutic settings, and provide freely available user-friendly computer programs for both trial design and conduct to facilitate broad application. The overarching goal is to provide designs including real-time adaptive decision making rules, in order to give practicing physicians ecient decision-making tools for biotherapies in order to obtain greater anti-disease e ects, longer survival time, and optimal patient safety.

PI_NAMEs: LIN, RUITAO ;THALL, PETER F (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Accounting;Acute Graft Versus Host Disease;Address;adverse outcome;Allogenic;Area;arm;B-Lymphocytes;Bayesian Method;Bayesian Modeling;Biological;Biological Markers;Biological Response Modifier Therapy;Biometry;Biotechnology;cancer immunotherapy;Cations;CD19 gene;CD22 gene;Cell surface;Cell Therapy;Cells;Characteristics;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical;clinical practice;Clinical Trials;Clinical Trials Design;Complex;computer program;Computer software;conventional therapy;cytokine release syndrome;Cytometry;Cytotoxic Chemotherapy;Decision Making;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;disease prognostic;Disease Progression;disorder subtype;Dose;Drops;engineered NK cell;Equilibrium;Evaluation;Futility;Future;Genes;Genomics;Goals;graphical user interface;Growth Factor;Guidelines;Hematologic Neoplasms;Hematological Disease;Heterogeneity;Hybrids;Immune response;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;individual patient;Malignant Neoplasms;Mass Spectrum Analysis;Mean Survival Times;Medical;Mesenchymal Stem Cells;Methods;Modeling;Modernization;Molecular Target;Monitor;Natural Killer Cells;Non-Small-Cell Lung Carcinoma;novel;Oncology;Operative Surgical Procedures;Outcome;Partial Remission;patient safety;patient subsets;Patients;Phase;Physicians;precision medicine;Precision therapeutics;primary outcome;Probability;prognostic;programmed cell death ligand 1;programs;Proteomics;Protocols documentation;Radiation;Randomized;Refractory;Research;research clinical testing;Resources;response;Risk;Running;Safety;Salvage Therapy;Sample Size;Savings;Schedule;screening;simulation;social;software development;Stable Disease;Statistical Models;Stem cell transplant;Steroid therapy;Structure;Subgroup;targeted agent;Testing;Therapeutic;Therapeutic Uses;Time;tool;Toxic effect;Transplant Recipients;trial comparing;trial design;tumor;user friendly software;user-friendly;vector;web site

PROJECT_TITLE: Bayesian Methods for Complex Precision Biotherapy Trials in Oncology

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE During this K25 award, Dr Reeves will develop a phylodynamic model of the HIV reservoir—the primary barrier to cure of HIV. The model will be validated using unique virologic, immunologic, and genetic data. The validated model will be used to study creation, persistence, and elimination of the HIV reservoir, filling a crucial gap in the HIV cure field.

PI_NAMEs: REEVES, DANIEL  (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Advisory Committees;Anatomy;Antigens;antiretroviral therapy;Archives;Automobile Driving;Award;Binding;Biological Assay;Biological Markers;biological research;biomarker discovery;career;CD4 Positive T Lymphocytes;Cell Proliferation;Cells;cohort;Collaborations;Communication;curative treatments;Data;Data Set;Dedications;design;Development;diverse data;DNA;DNA Sequence;DNA-Directed DNA Polymerase;Ecology;Ensure;Epidemic;Evolution;Excision;Face;Financial Hardship;Future;gene therapy;Genes;Genetic;Goals;HIV;HIV Infections;Human;human data;Immunologics;Immunology;improved;in silico;Individual;Infection;infectious disease model;integration site;Knowledge;Laboratories;Laws;Learning;Lymphocyte;Maintenance;mathematical model;Memory;memory CD4 T lymphocyte;Mentors;Mentorship;Methods;Modeling;Modernization;mortality;Nature;Non-linear Models;novel;Persons;Phylogenetic Analysis;Physics;Play;Population Dynamics;Primary Infection;Process;Program Sustainability;Proliferating;Publishing;Regimen;Research;Research Institute;Research Personnel;Research Training;Resolution;Resource-limited setting;response;RNA-Directed DNA Polymerase;Role;San Francisco;Sequence Analysis;side effect;skills;social stigma;standard of care;Statistical Models;statistics;Structure;success;symposium;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;tool;Training;Training Programs;Trees;Universities;Viral;Viral Load result;virology;Virus Integration;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Simulating persistence and elimination of the HIV reservoir

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Multiple sclerosis (MS) diagnostic delay is common and can have severe and life-long consequences with each preventable relapse representing an estimated additional cost of $8,200-$24,180. The problem of misdiagnosis is also significant as approximately 20% of patients referred to an MS center with a previous diagnosis of MS have been found to be misdiagnosed, 2/3 of those misdiagnosed are treated, and healthcare expenditures related to MS disease-modifying therapies (DMT) account for 40% of the total $48 billion associated cost of MS care. We propose the use of the central vein sign as a diagnostic biomarker in MS to allow early and accurate diagnosis.

PI_NAMEs: ONTANEDA, DANIEL  (contact);SATI, PASCAL ;SICOTTE, NANCY L

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: accurate diagnosis;Affect;American;Anatomy;Appearance;Autoimmune Diseases;Biological;Biological Markers;Brain;Brain scan;Caring;Central Nervous System;Central Vein;Clinical;clinical care;clinical decision-making;CNS autoimmune disease;Consumption;cost;Cross-Sectional Studies;Demyelinating Diseases;Demyelinations;Detection;detection method;Development;Diagnosis;diagnosis standard;Diagnostic;diagnostic biomarker;diagnostic criteria;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;disability;Disease;Early Diagnosis;Early treatment;Echo-Planar Imaging;Enrollment;Equipoise;Evaluation;Event;Exposure to;Goals;Health Expenditures;Image;improved;Individual;Inflammatory;Ischemia;Laboratories;Lesion;Life;Literature;Location;Magnetic Resonance Imaging;Measurement;Measures;meetings;Methodology;Migraine;Multicenter Studies;Multiple Sclerosis;Multiple Sclerosis Lesions;neuroimaging;Neurologic Symptoms;Participant;Pathology;Patients;Pattern;Persons;Physiologic pulse;Population;Property;prospective;public health intervention;public health relevance;Publishing;Radiology Specialty;Recommendation;Relapse;relapse prevention;Relapsing-Remitting Multiple Sclerosis;Resolution;Risk;Scanning;Scoring Method;Sensitivity and Specificity;Site;Solid;Specificity;Speed;Symptoms;Syndrome;Testing;Time;Translations;United States;Validation;white matter

PROJECT_TITLE: Central Vein Sign: A Diagnostic Biomarker in Multiple Sclerosis

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer (PDA) is a deadly malignancy characterized by extensive fibrosis and immune suppression. The complex interplay between tumor cells and their surrounding stroma has not been fully elucidated. Since current therapeutic approaches targeting individual components of the tumor microenvironment have failed to benefit patients, the goals of the project are to: 1) define Hedgehog-dependent tumor/fibroblast/immune cross talk, 2) elucidate Hedgehog-dependent tumor/fibroblast/endothelial cross talk, and 3) investigate a novel role for SLIT ligands in PDA.

PI_NAMEs: STEELE, NINA G (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Ablation;Address;Advisory Committees;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;Award;Behavior;Biology;Cancer Biology;Cancer Control;Cancer Etiology;career development;Cell Physiology;Cells;Cessation of life;Clinical Trials;Coculture Techniques;Collaborations;Communication;Complex;Cre driver;Data;Development;Development Plans;Disease;dosage;effective therapy;Endothelial Cells;Endothelium;Epithelium;Erinaceidae;experimental study;Fibroblasts;Fibrosis;Future;Gene Expression;gene function;Genes;Genetic study;Goals;Human;Immune;Immune response;Immune Targeting;Immunology;immunoregulation;Immunosuppression;in vivo;Individual;Infiltration;inhibitor;International;Invaded;Investigation;Laboratories;Laboratory Research;Lead;Ligands;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mentors;Mentorship;Michigan;mouse model;Myeloid-derived suppressor cells;Neoplasm Metastasis;neoplastic cell;neural;novel;novel strategies;Pancreas;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;paracrine;Pathway interactions;patient response;Patients;Pharmacology Study;Phase;Play;Population;Population Heterogeneity;Reaction;receptor;Research;response;Role;Signal Transduction;skills;smoothened signaling pathway;Survival Rate;Testing;Therapeutic;tumor;Tumor Angiogenesis;tumor growth;tumor metabolism;tumor microenvironment;Tumor-Derived;tumor-immune system interactions;Universities;Vascularization;Work

PROJECT_TITLE: Investigating Cellular Communication in the Tumor Microenvironment in Pancreatic Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Barrett’s Esophagus (BE) is a prevalent disease in the US population. There are cell intrinsic (TP53 mutations) and cell extrinsic (extracellular matrix properties) mechanisms that foster BE pathogenesis. These mechanisms will be investigated in novel human induced pluripotent stem cell-derived organotypic raft and patient-derived 3D organoid culture systems to define how BE dysplasia occurs and to uncover translational therapeutic strategies.

PI_NAMEs: CRUZ ACUÑA, RICARDO  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Adenocarcinoma;Adhesives;Advisory Committees;Affect;Barrett Epithelium;Barrett Esophagus;base editing;Biochemical;Biocompatible Materials;Biologic Characteristic;Biology;Biomechanics;Biomedical Engineering;career development;Cells;Characteristics;Clinic;clinically significant;collaborative environment;Cues;Data;defined contribution;density;Development Plans;Disease;Dysplasia;effectiveness testing;Engineering;Environment;Epigenetic Process;Epithelial Cells;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophagus;Event;Extracellular Matrix;Faculty;Fostering;Foundations;Funding;Gene Expression;Gene Expression Profile;General Population;Genes;genomic aberrations;Growth;High grade dysplasia;Human;human disease;human induced pluripotent stem cells;human model;Hyaluronic Acid;Hydrogels;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;Injury;innovation;Institution;intestinal epithelium;Intestinal Metaplasia;MDM2 gene;Medical center;Mentored Research Scientist Development Award;Mentorship;Metaplasia;Modeling;Morphology;Mutation;novel;novel therapeutics;Organoids;Pathogenesis;Pathway interactions;Patients;Peptides;permissiveness;Persons;Pharmaceutical Preparations;Population;Pre-Clinical Model;pre-doctoral;Prevention;Proliferating;Property;Research;Research Personnel;Research Proposals;response;Risk;Role;Signal Transduction;small molecule inhibitor;Squamous Epithelium;stem cell derived tissues;stem cell model;System;targeted treatment;tenure track;Testing;therapeutic target;Time;Tissues;TP53 gene;Training;translational medicine;translational therapeutics;treatment response;United States National Institutes of Health;Universities;Work;Xenograft procedure

PROJECT_TITLE: Engineered Hydrogel Elucidates the Contribution of ECM Stiffness to Barrett's Esophagus Pathogenesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Prevention;Rehabilitation

ORG_CITY: Riverside

ORG_NAME: EMMA PENDLETON BRADLEY HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE This project will test repetitive transcranial magnetic stimulation (rTMS) for its ability to 1) normalize functioning in brain circuits that contribute to compulsive behavior, 2) reduce compulsions during ERP, an effective form of behavior therapy for youth with OCD. It will also test whether these are effective ways to improve clinical outcomes. The R61 phase will randomly assign 60 youth and young adults with OCD to receive ERP with sham (“fake” rTMS) vs. one of two different active rTMS regimens. The R33 Phase will randomly assign 60 youth and young adults with OCD to receive ERP with sham or active rTMS. Results of this study will inform understanding of treatment options in pediatric OCD.

PI_NAMEs: BENITO, KRISTEN G (contact);CONELEA, CHRISTINE A

PROGRAM_OFFICER_NAME: GRABB, MARGARET CHRISTINE

PROJECT_TERMS: 2 arm randomized control trial;Adult;Adverse event;Aftercare;Age;aged;Area;arm;Award;Behavior;Behavior Therapy;Behavioral;Brain;Childhood;Clinical;Clinical Trials;compulsion;Compulsive Behavior;Corpus striatum structure;Data;design;Distress;Dorsal;efficacious treatment;Equilibrium;Exposure to;flexibility;Fright;Functional Magnetic Resonance Imaging;functional outcomes;Goals;Habits;improved;Lateral;learning extinction;Left;Link;Masks;Measures;Mediating;Motor;neural;Neurocognitive;neuromechanism;novel;Outcome;Phase;Prefrontal Cortex;Prevention;Public Health;Randomized;Regimen;repetitive transcranial magnetic stimulation;Research;response;Rest;Safety;Sampling;Severities;Study models;Subgroup;success;symptomatic improvement;Symptoms;Task Performances;Testing;Transcranial magnetic stimulation;treatment arm;treatment effect;Treatment outcome;treatment response;virtual;Work;young adult;Youth

PROJECT_TITLE: Transcranial Magnetic Stimulation to Augment Exposure and Response Prevention for Pediatric OCD


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health;Telehealth

ORG_CITY: CHAPEL HILL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative This Center aims to advance the clinical and translational research of virtual care by building a coalition of Real-World Data, experts, and validated frameworks that enable researchers and organizations to ensure equitable and sustainable virtual care by supporting implementation science and workforce development.

PI_NAMEs: KHAIRAT, SAIF  (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Academic Medical Centers;Acceleration;access disparities;Address;Administrator;Adoption;American;care costs;care delivery;care seeking;care systems;Caring;Clinical;Clinical Research;Clinical Sciences;Complex;Consensus;Consult;Cost Savings;Country;COVID-19 pandemic;Data;Data Collection;Dedications;Development;digital delivery;Disease;Education;Educational workshop;Effectiveness;empowerment;Ensure;Environment;Equitable healthcare;Equity;Ethnic Origin;Evaluation;evidence base;experience;Fee-for-Service Plans;Foundations;Funding;Future;geographic barrier;Goals;Health;health care availability;health care delivery;health care service;health disparity;Health Services Accessibility;Health system;Healthcare;Human;implementation framework;implementation science;improved;Infrastructure;innovation;Institution;instrument;Interview;Investigation;Knowledge;Learning;Measurement;Measures;Modeling;Nature;North Carolina;Outcome;parity;Patients;payment;Pediatric Research;Policies;Policy Developments;Policy Maker;Population;population health;Positioning Attribute;preventable death;Productivity;Program Sustainability;programs;Provider;Race;Research;Research Personnel;research study;Research Support;research to practice;Resources;Risk;Rural;Series;Services;Site;skills;Socioeconomic Status;socioeconomics;Structure;success;telehealth;Time;tool;Training;Translational Research;underserved area;Underserved Population;Universities;virtual healthcare;virtual world;Vision;webinar;Work;Workforce Development

PROJECT_TITLE: Center for Virtual Care Value and Equity (ViVE)