NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Services;Mental Health;Mental Illness;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Mental illness (anxiety and depression) and Non-communicable diseases (Hypertension and Diabetes Mellitus) are major global problems. We propose to test a Behavioral Community-based COmbined Intervention for MEntal Health and Noncommunicable Diseases (BECOME) delivered by Community Health Workers. If successful, the results of this study can provide an intervention that can jointly improve co-morbid conditions of mental illnesses and non-communicable diseases and also help us understand the implementation mechanisms via which the intervention works.

PI_NAMEs: ACHARYA, BIBHAV  (contact);SAPKOTA, SABITRI

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: Address;Anxiety;anxiety symptoms;Attitude;Behavior;Behavior Therapy;Behavioral;beneficiary;Blood Pressure;Caring;Cause of Death;Cessation of life;Clinical Protocols;Cluster randomized trial;Collaborations;Communities;Community Health Aides;comorbidity;Complex;cost;Cost Analysis;cost effective;depressive symptoms;Diabetes Mellitus;Diet;disability;Disease;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation study;evidence base;experience;Face;fasting glucose;follow-up;Funding;Geography;Government;Guidelines;health care delivery;Health system;Healthcare;Healthcare Systems;Heterogeneity;Home;Hypertension;implementation barriers;implementation evaluation;implementation outcomes;implementation research;implementation strategy;improved;innovation;Intervention;Intervention Studies;Leadership;Life Style Modification;low and middle-income countries;Mental Depression;Mental disorders;Mental Health;Methods;Mobile Health Application;Motivation;motivational enhancement therapy;Nepal;Participant;Patient Recruitments;Patients;Persons;Pharmaceutical Preparations;Physical activity;Policy Maker;primary care provider;primary outcome;Provider;Psychotherapy;Public Health;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recording of previous events;Reporting;Research;Resource-limited setting;Risk Factors;Risk Reduction;risk sharing;scale up;secondary outcome;Severities;Site;skills;social norm;sociocultural determinant;Stress;stress reduction;symposium;Testing;Time;time use;Tobacco;Tobacco use;Training;treatment adherence;United States National Institutes of Health;Work;World Health Organization

PROJECT_TITLE: A type II hybrid implementation-effectiveness study of BECOME (BEhavioral Community-based COmbined Intervention for MEntal Health and Noncommunicable Diseases) delivered by community health workers


ADMINISTERING_IC: EB

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Digestive Diseases;Esophageal Cancer;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: One of the biggest challenges in reducing the mortality of esophageal adenocarcinoma is screening for people at high risk for developing this deadly cancer. In this grant, we will create and validate a swallowable tethered capsule screening tool that obtains targeted biopsies of regions of the esophagus that harbor molecular abnormalities that confer risk for developing cancer. Analysis of these biopsies will determine who needs intervention, intercepting esophageal cancer before it has a chance to form.

PI_NAMEs: TEARNEY, GUILLERMO J (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Aneuploidy;Area;Back;Barrett Esophagus;Biological Markers;biomarker discovery;biomarker identification;Biopsy;capsule;Cells;Clinical;Clinical Research;cohort;Color;Columnar Cell;Conscious Sedation;cost;Cyclin A;Data;Death Rate;deep learning;deep learning algorithm;design;Devices;Diagnosis;Disease remission;Dysplasia;Early Intervention;Endoscopic Biopsy;Endoscopy;Epithelium;Esophageal Adenocarcinoma;Esophageal Intraepithelial Neoplasia;Esophageal Tissue;Esophagus;Fiber;Fluorescence;follow-up;Forcep;Freezing;Future;Gastroesophageal reflux disease;General Population;Genes;Genetic;Grant;Healthcare Systems;High Prevalence;high risk;Histologic;Histology;Image;Image Analysis;image guided;Image Guided Biopsy;imaging biomarker;Imaging technology;improved;in vivo;Incidence;innovation;Intercept;Intervention;Laboratories;Light;Light-Scattering Spectroscopy;Location;Malignant neoplasm of esophagus;Malignant Neoplasms;Metabolic;Metaplasia;Methods;Methylation;microendoscopy;microscopic imaging;Microscopy;Modification;Molecular;Molecular Abnormality;mortality;multimodality;Mutation;novel;Nurses;nursing administration;Optical Coherence Tomography;Optics;overexpression;Oxidation-Reduction;Patients;Persons;Population;population based;predictive marker;primary care setting;progression marker;progression risk;Proxy;real-time images;Research;Risk;Rotation;Sampling;screening;Screening procedure;Sedation procedure;Site;spectrograph;Spectrum Analysis;standard of care;System;targeted imaging;Techniques;Technology;Testing;Time;tissue biomarkers;Tissue Sample;Tissues;TP53 gene;Validation;Work

PROJECT_TITLE: Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Hematology;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: HARARE

ORG_COUNTRY: ZIMBABWE

ORG_FIPS: ZI

ORG_NAME: COLLEGE OF HEALTH SCIS UNIV OF ZIMBABWE

PHR: Narrative The SHAZ research group consist of Zambian and Zimbabwean researchers who aspire to join and contribute to the SCD in Sub-Saharan network consortium registry, biorepository and research activities as well as to improve the quality of care for SCD patients in Zimbabwe and Zambia.

PI_NAMEs: KUONA, PATIENCE  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Acute;Address;Adult;adverse outcome;Africa South of the Sahara;Area;biobank;Biological Specimen Banks;Blood flow;Caring;Cerebrovascular Circulation;Child;Chronic;Clinic;Clinical;clinical phenotype;cohort;Cohort Studies;Communication;community engagement;Comprehensive Health Care;Country;Data;design;Diagnosis;Disease;Disease Management;disease registry;Electronics;Energy Intake;Enrollment;Ensure;Epidemiology;Ethics;evidence base;Evidence based practice;Fetal Hemoglobin;follow-up;Food;genetic counselor;Goals;Growth;Guidelines;Hematologist;Hemoglobin concentration result;Hemoglobinopathies;Heritability;hydroxyurea;implementation research;implementation science;implementation study;improved;improved outcome;Individual;Infection prevention;Infrastructure;Laboratory Research;Laboratory Scientists;Maintenance;Modeling;Morbidity - disease rate;mortality;Natural History;Neonatal Screening;Newborn Infant;Nurses;nutrition;operation;outcome prediction;outreach program;Pain management;Paste substance;Patient-Focused Outcomes;Patients;pediatrician;Pharmacogenomics;Physicians;Policies;Procedures;Productivity;programs;Prophylactic treatment;Protocols documentation;quality assurance;Quality Control;Quality of Care;recruit;Registries;Research;Research Activity;Research Infrastructure;Research Personnel;research study;Resources;Risk Factors;screening;Shipping;Sickle Cell Anemia;sickling;Site;sound;Standardization;Stroke;Teaching Hospitals;tool;Training;Training and Infrastructure;transmission process;Universities;uptake;young adult;Zambia;Zimbabwe

PROJECT_TITLE: Sickle Hemoglobinopathy reseArch in Zimbabwe (SHAZ)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Hematology;Infectious Diseases;Lung

ORG_CITY: NEW ORLEANS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: PROJECT NARRATIVE  The COVID-19 pandemic that took lives of more than 500,000 U.S. citizens is the evidence that emerging infectious diseases are a serious threat to human health. Many patients who died from COVID-19 and other infectious diseases developed severe thrombotic complications shortly after disease symptoms were manifested, and their lives could be saved by predictive diagnosis of disease severity and timely treatment. The goal of the proposed research is develop technology for infectious disease severe assessment that requires only a single drop of venous or capillary blood and can be performed inside a hospital, in a clinic or outpatient center, or at home.

PI_NAMEs: KHISMATULLIN, DAMIR B (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Acoustics;Activated Partial Thromboplastin Time measurement;Acute Respiratory Distress Syndrome;Anticoagulants;Blood;Blood capillaries;Blood coagulation;Blood specimen;Blood Tests;Cessation of life;Clinic;Clinical;Clinical Data;Coagulation Factor Deficiency;Coagulation Process;Communicable Diseases;COVID-19;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;COVID-19 vaccine;Critical Illness;cytokine;cytokine release syndrome;Data;Deterioration;Development;Devices;Diagnosis;Disease;disease diagnosis;disorder risk;Disseminated Intravascular Coagulation;Drops;Drug Monitoring;Emerging Communicable Diseases;Endothelial Cells;Event;experience;experimental study;Exposure to;Factor XIII;feasibility testing;Fibrin fragment D;Fibrinogen;Fibrinolysis;Fibrinolytic Agents;Fingers;Flow Cytometry;Gene Expression Profiling;Goals;Health;healthy volunteer;Hemorrhage;Heparin;Home;Hospitals;Human;Hyperactivity;Immune system;Inflammatory;Influenza;Inpatients;Ischemic Stroke;Life;Link;Lung;Measurement;Measures;Methods;Modification;Monitor;mortality;multiplex assay;Operating Rooms;Outcome;outpatient facility;Outpatients;pandemic disease;Patients;Persons;Plasma;platelet function;Pneumonia;point of care;Protocols documentation;rapid test;Recording of previous events;Reference Values;Research;Respiratory Tract Infections;response;Risk Assessment;RNA;Sampling;Sepsis;severe COVID-19;Severities;Severity of illness;Standardization;Surface;Symptoms;System;Techniques;Technology;technology development;Testing;Therapeutic;Thrombolytic Therapy;Thrombosis;thrombotic;thrombotic complications;United States;Vascular Endothelial Cell;Venipunctures;Venous;Venous blood sampling;venous thromboembolism

PROJECT_TITLE: Drop-of-blood technology for diagnosis and therapeutic drug monitoring in patients with infectious disease

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The group A strep bacterium is responsible for serious, life-threatening diseases. We are investigating how a major virulence factor of group A strep, the M protein, gives the bacterium the ability to avoid killing by the immune system. Our studies on the M protein will provide knowledge that will be applicable to the design of novel therapeutics or preventive strategies aimed at combating group A strep infections.

PI_NAMEs: GHOSH, PARTHO  (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: 3-Dimensional;Acute;Amino Acid Sequence;Amino Acids;Antibodies;Antigenic Variation;Antigens;Attenuated;Autoimmune;Bacteria;Binding;Binding Proteins;Blood;Cell Wall;Collaborations;Complement 3b;complement 4b-binding protein;Complement Factor H;Complex;Consensus;Crystallography;Deposition;design;Development;Disease;Fibrinogen;Goals;Hand;Human;Immune;Immune system;Immunity;Infection;Inflammatory;Knowledge;Life;Microbiology;Morbidity - disease rate;mortality;multiple myeloma M Protein;Nature;neutralizing antibody;novel;novel therapeutics;Opsonin;pathogenic bacteria;Pattern;Phagocytes;Prevention strategy;Productivity;Property;protein complex;Proteins;Public Health;Publishing;recruit;Reporting;Research Personnel;Resistance;Role;Sea;Streptococcus pyogenes;success;Surface;Testing;Therapeutic;uptake;Vaccine Design;Vaccines;Variant;Virulence;Virulence Factors;Work;X-Ray Crystallography

PROJECT_TITLE: Evasion of host immunity by the M protein

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Microbiome;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Public Health Relevance This proposal aims to dissect the underlying mechanisms of how the host (Tc1-cells) and the liver microbiota (L. reuteri) affects AIH-like pathology and will assess the efficacy of therapeutic interventions (Trp diet, blocking AhR) to alleviate AIH pathology. The proposal will have a significant positive impact on human health because it will advance our understanding of the pathophysiology of AIH and assess rational therapeutic interventions for patients with AIH. Thus, this work will directly support the NIDDK mission of developing fundamental knowledge that will help reduce the burden of human disease, and improve the health of patients with autoimmune hepatitis.

PI_NAMEs: MEISEL, MARLIES  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Affect;Agonist;Antibiotic Therapy;Antigens;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Autoimmune Hepatitis;Autoimmunity;autoinflammatory;Automobile Driving;Bacterial Translocation;Biological Models;CD8-Positive T-Lymphocytes;Cells;Chronic;Cirrhosis;Clonal Expansion;Clone Cells;commensal bacteria;Concanavalin A;Cytoprotection;Data;Dependence;Diet;dietary;Dioxygenases;Disease;effector T cell;efficacy evaluation;end stage liver disease;Environmental Risk Factor;Epidemiology;Epigenetic Process;Fibrosis;Functional disorder;Genetic;Genetic Predisposition to Disease;genetic signature;Genetic Transcription;Germ-Free;Health;Hematopoietic;Hepatic;Hepatic Tissue;Hepatitis;Hepatocyte;Human;human disease;Immune;Immunity;immunoregulation;Immunosuppressive Agents;improved;Individual;Indole-3-Carbinol;inhibitor;Interferon Type II;Interferons;Knowledge;Lactobacillus;Lactobacillus reuteri;Link;Literature;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver transplantation;Lupus;Mediating;microbiome;microbiota;Mission;Modeling;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Pathogenicity;Pathology;Patients;Play;pre-clinical;Production;programs;public health relevance;Publishing;Receptor Inhibition;Receptor Signaling;Refractory;Role;Severities;Signal Transduction;single-cell RNA sequencing;systemic inflammatory response;T cell differentiation;TC1 Cell;Testing;Tetanus Helper Peptide;Therapeutic;Therapeutic Intervention;Tissues;Tryptophan;Wild Type Mouse;Work

PROJECT_TITLE: Systemic immunoregulatory consequences of bacterial translocation during health and disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Microbiome;Nutrition;Obesity;Precision Medicine;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE This project seeks to identify gut microbial features and metabolites of gut microbial origin that explain inter- individual differences in post-intervention changes in cardiometabolic risk and adiposity in two randomized Mediterranean diet (MedDiet) intervention studies. We will also investigate long-lasting, post-intervention effects of combined MedDiet and autologous fecal microbiota transplantation (derived from the time of maximal weight reduction) and characterize gut microbial changes during and after the combined interventions in a randomized controlled trial. Based on these unique resources and our experienced transdisciplinary team, the proposed research will provide unprecedented insight into the functional role of the gut microbiome in explaining inter-individual variability in response to dietary interventions and lead to translational and reproducible evidence for novel gut microbiome-guided dietary strategies for cardiometabolic disease prevention.

PI_NAMEs: WANG, DONG  (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Adherence;Amines;authority;Autologous;biobehavior;Biochemical;Biological;Biological Markers;Body Weight;Body Weight decreased;burden of illness;Butyrates;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cost efficient;Data;design;Development;Diet;dietary;Dietary Intervention;Dietary Lead;Dimensions;disorder prevention;disorder risk;Enzymes;epidemiology study;experience;fasting glucose;fecal transplantation;Feces;follow-up;Food;Foundations;Genetic Transcription;gut microbiome;gut microbiota;Health;improved;Individual;Individual Differences;individual variation;insight;inter-individual variation;Intervention;intervention effect;Intervention Studies;Intervention Trial;Israel;Lead;Lipids;Medicine;Mediterranean Diet;Memory;metabolomics;Metagenomics;metatranscriptomics;Microbe;microbial;microbiome research;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutritional Study;Obesity;observational cohort study;Outcome;Oxides;Participant;personalized approach;Persons;Plasma;Population;post intervention;precision nutrition;preservation;Prevention;Prevotella;Production;prospective;protective effect;Publishing;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Reproducibility;Research;Research Design;Research Priority;Resolution;Resources;response;Role;Shotguns;Strategic Planning;Subgroup;Taxonomy;Technology;Testing;Time;TNF gene;Translations;United States National Institutes of Health;Visceral fat;Volatile Fatty Acids

PROJECT_TITLE: The Gut Microbiome and Personalized Mediterranean Diet Interventions for Cardiometabolic Disease Prevention

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Thailand remains one of the countries with the largest population of people living with HIV (PLWH) in the Asian-Pacific region. In Thailand, as in other middle-income Asian countries, HIV stigma has been impacted in PLWH and their family members is a pressing health concern. The purpose of this study is to culturally adapt and evaluate the feasibility of a 4 weekly 2-hour group-based stigma reduction intervention to promote health engagement.

PI_NAMEs: CHEN, WEI-TI  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Affective;arm;Asia;Asian;Behavior;Belief;Buddhism;Caring;Cognitive;Compassion;Country;culturally appropriate intervention;Data;Death Rate;Deterioration;Discrimination;Epidemic;ethnic minority;evidence base;Family member;feasibility testing;Future;gender minority;Goals;Health;health care availability;Health Promotion;Health Services;HIV;Hour;Image;Income;Individual;innovation;insight;internalized stigma;Intervention;Intervention Studies;Interview;Manuals;marginalization;Measures;men who have sex with men;Mental Health;Methods;mindfulness;Modeling;Modernization;Myanmar;operation;Outcome;Outcome Assessment;Participant;Pathway interactions;Patients;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Philosophy;physical conditioning;Pilot Projects;Population;Prevalence;primary outcome;Procedures;Process;protective behavior;Protocols documentation;psychoeducation;Randomized;Randomized, Controlled Trials;Research;Risk Factors;Role;Sampling;secondary outcome;Self Management;self-compassion;sex;Sexual and Gender Minorities;social;social stigma;Social support;substance user;Thailand;transgender;Treatment Efficacy;treatment group;Underserved Population;United States;Viral Load result;Woman

PROJECT_TITLE: Buddhism and HIV Stigma in Thailand: An Intervention Study

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The cerebellum contains more neurons and uses more energy than the rest of the brain combined, and in addition to its well-known role in motor control, this remarkable structure has been implicated in language, working memory, cognitive control, and social cognition. Prominent theories of cerebellar computation typically focus on its role in error-based motor learning. The focus of this project is to explore the idea that cerebellar contributions to learning in nonmotor domains may involve the same prediction and error-based learning principles observed in cerebellar motor learning, thus refining current models of cerebellar function in health and disease.

PI_NAMEs: MCDOUGLE, SAMUEL DAVID (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Animals;Architecture;Association Learning;Behavior;Behavioral;Brain;Brain region;Cerebellar Diseases;Cerebellum;Clinical;Cognition;cognitive control;cognitive task;Computational Technique;Computer Analysis;Computer Models;design;Development;Disease;Disparate;Event;experimental study;eyeblink conditioning;Feedback;Functional Magnetic Resonance Imaging;Health;Heterogeneity;Human;Individual;insight;Investigation;Knowledge;Language;Learning;learning network;Link;Measures;Modeling;Motor;motor control;motor learning;Movement;multimodality;neuroimaging;Neurons;novel;Outcome;Pathology;Positioning Attribute;Process;Psychological reinforcement;Reflex action;Research;Rest;Rewards;Role;Sampling;Sensory;sensory input;Short-Term Memory;Signal Transduction;social cognition;statistical learning;Stimulus;Structure;Testing;theories;Time;vestibular system;Visual;Work

PROJECT_TITLE: Generalized prediction errors in the human cerebellum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-N(02)M]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Heart Disease;Heart Disease - Coronary Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Women with a history of preeclampsia are at increased risk for heart disease, and new treatments are needed to help prevent heart attacks and death in this population. This work proposes new insights, using novel noninvasive imaging techniques and biomarkers of inflammation and stress to help identify factors linked to heart disease, and help understand factors that affect disease of the blood vessels in this high risk population of young women.

PI_NAMEs: HAYS, ALLISON G (contact);VAUGHT, ARTHUR JASON

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Affect;age group;angiogenesis;Angiotensins;Atherosclerosis;Autoantibodies;Biological;Biological Markers;Biology;blood pressure elevation;Blood Vessels;Cardiology;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Centers of Research Excellence;Cessation of life;Clinic;Clinical;cohort;Communication;comparison control;Coronary;Coronary Arteriosclerosis;Coronary Vessel Anomalies;Data;Depressed mood;design;Development;Diagnosis;Discipline of obstetrics;Disease;Disease Outcome;Endocrinology;Endothelial Cells;endothelial dysfunction;Endothelium;Event;experience;Functional disorder;Funding;Future;Gender;Gender Role;General Population;Health;heart disease risk;Heart Diseases;Hematological Disease;high risk population;High Risk Woman;Hormones;Human;Hypertension;imaging biomarker;Imaging Techniques;Impairment;improved;Inflammation;inflammatory marker;Injury;insight;Intervention;Intervention Studies;Ischemia;Knowledge;late life;Life;Link;Lived experience;Magnetic Resonance Imaging;maternal morbidity;Maternal Mortality;Measures;Medical;Methods;mortality;multidisciplinary;Myocardial Infarction;Neighborhoods;Nodal;Non-Insulin-Dependent Diabetes Mellitus;non-invasive imaging;normotensive;novel;novel therapeutic intervention;Obesity;Organ;Outcome;Oxidative Stress;Pathogenesis;Patients;perceived stress;Physiological;Placenta;Play;Population;Postpartum Hypertension;Postpartum Period;Postpartum Women;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy disorder;prepregnancy;prevent;Prognostic Marker;programs;Prospective Studies;Psychological Stress;Psychosocial Stress;Public Health;Receptor, Angiotensin, Type 1;Recording of previous events;recruit;Renin-Angiotensin System;Reporting;Reproducibility;Resources;Risk;Risk Factors;Role;Severities;sex;social;Social Behavior;social health determinants;Specialized Center;Stratification;Stress;systemic inflammatory response;Techniques;Testing;Time;United States National Institutes of Health;Vascular Diseases;vascular injury;Woman;Women's mortality;Work;young woman

PROJECT_TITLE: Stress, inflammation and coronary endothelial injury in preeclampsia


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Substance Misuse

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Substance use disorders (SUDs) are pervasive threats to global public health, for which there are few pharmacotherapeutic agents. The aim of the symposium is an interdisciplinary exposition of the recent, most important, research-related advances in medicinal chemistry, pharmacology and (pre)clinical research, related to drug abuse. The emphasis is on laboratory findings that inform the search for SUD pharmacotherapies and to respond to paradigm shifts in the field and emergent threats to at risk populations.

PI_NAMEs: MAKRIYANNIS, ALEXANDROS  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;addiction;Address;Affect;Affective;Animals;Basic Science;Behavioral;behavioral pharmacology;Biology;Biomedical Research;biomedical scientist;Biotechnology;Boston;career;Chemicals;Chemistry;Cities;Clinical;clinical center;clinical practice;Clinical Research;Cognition;combat;Communication;Communities;Community Participation;Complex;design;Designer Drugs;Disease;Drug abuse;drug discovery;drug of abuse;Emotional;Etiology;Exposure to;Frustration;Genetic;Goals;Grant;Health Personnel;Healthcare;Hospitals;Industry;interest;Knowledge;Laboratory Finding;Massachusetts;Medical;medical schools;meetings;Modeling;National Institute of Drug Abuse;Nature;Neurobiology;neuronal circuitry;New Agents;next generation;novel;outreach;Pathologic;Pathology;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Phenotype;Population;Population Group;Populations at Risk;Process;programs;Public Health;Research;Research Institute;Research Personnel;Risk;Scientist;Services;Social Behavior;Standardization;structural biology;Substance Use Disorder;success;symposium;Therapeutic;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Universities;vigilance

PROJECT_TITLE: Chemistry and Pharmacology of Drugs of Abuse Annual Symposium


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Clinical Research;Lung;Networking and Information Technology R&D (NITRD)

ORG_CITY: DURHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative The project aims to systematically evaluate and optimize quantitative CT imaging biomarkers in Chronic Obstructive Pulmonary Disease (COPD) patients, across scanner makes and models, imaging parameters, and patient attributes. This will be performed by developing and using in silico models of COPD patients and CT scanners. The project will position CT alongside other diagnostic methods to accurately and precisely characterize COPD.

PI_NAMEs: ABADI, EHSAN  (contact)

PROGRAM_OFFICER_NAME: HU, TOM CHIH-CHUANG

PROJECT_TERMS: Algorithms;Anatomy;Artificial Intelligence;artificial intelligence algorithm;Biological Markers;Cause of Death;Chronic Obstructive Pulmonary Disease;cohort;Communities;Comparative Study;Complex;Computed Tomography Scanners;Computer Models;Coupled;Data;Data Set;Densitometry;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;disease diagnosis;disease model;Effectiveness;Environmental Risk Factor;Evaluation;Exposure to;Goals;human model;Image;image processing;imaging biomarker;improved;in silico;in vivo;insight;Interstitial Lung Diseases;Libraries;Longitudinal Studies;Lung;Lung Diseases;Magnetic Resonance Imaging;Measurement;Methods;Modality;Modeling;Monitor;Patient imaging;Patients;Persons;Photons;Physiology;Positioning Attribute;Prevalence;Protocols documentation;Provider;Pulmonary Emphysema;quantitative imaging;radiation absorbed dose;Radiation exposure;reconstruction;Recording of previous events;Reporting;Reproducibility;Research;Resolution;Role;Severities;Severity of illness;Smoking;Spirometry;Symptoms;System;Technology;Time;tool;Tube;Variant;verification and validation;virtual;virtual imaging;virtual patient;voltage;X-Ray Computed Tomography

PROJECT_TITLE: Accuracy and Precision in CT Quantification of COPD Through Virtual Imaging Trials

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Congenital Heart Disease (CHD) is the most common major birth defect, affecting an estimated 1 in 130 live births, yet the cause remains elusive. CHD is tightly associated with heterotaxy syndrome, a condition in which numerous major organs including the heart, lungs and liver are positioned abnormally in the chest and abdomen. This study has the potential to increase our understanding of heterotaxy and CHD by elucidating the fundamental processes that regulate the distribution of the heart and other organs during development.

PI_NAMEs: YUAN, SHIAULOU  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Abdomen;Address;Affect;base;Binding;Binding Sites;Biological Assay;Biology;Body Patterning;Calcium;Calcium Channel;calcium indicator;Calcium Oscillations;Calcium Signaling;Calcium-Binding Proteins;Calmodulin;Calmodulin-Binding Proteins;Cardiac;cardiogenesis;Cardiovascular system;Cations;Cell Physiology;Cells;Chest;Cilia;ciliopathy;cilium motility;Complex;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Cues;Cytoplasm;Data;Data Analyses;Defect;Development;Diagnostic;Disease;Embryo;Embryology;Embryonic Development;Embryonic Fluid;Eukaryotic Cell;Extracellular Fluid;fluid flow;Gap Junctions;Gene Expression;Genetic;Handedness;Heart;Human;Image;improved outcome;in vivo;in vivo calcium imaging;innovation;Ions;Knowledge;Left;Light;Live Birth;Liver;Lung;Machine Learning;Mediating;Microscopy;Microtubules;Modeling;Molecular;Morphogenesis;mutant;Mutation;Myocardial;Natural regeneration;Nodal;novel;optogenetics;Organ;Organelles;Patient-Focused Outcomes;Pattern;Perception;Phenotype;PKD2 protein;Play;Positioning Attribute;Process;Proteins;receptor;Regulation;Reporter;Research;Role;Signal Transduction;Situs Inversus;spatiotemporal;Structure;Syndrome;Techniques;Testing;Therapeutic;tool;Transducers;Translating;transmission process;Vascular Diseases;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Optogenetic regulation of intra-ciliary calcium signaling in cardiac situs development

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Aging;Cancer;Genetics;Hematology;Radiation Oncology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK BLOOD CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Mitigation and protection of bone marrow cells, particularly hematopoietic (blood forming) stem cells, from radiation and aging-induced acute and permanent injury is critical for the quality of life of cancer patients receiving radiotherapy and for the elderly. This study will investigate pharmaceutic and genetic inhibition of hematopoietic stress regulatory gene, latexin, in radiation protection and stem cell rejuvenation.

PI_NAMEs: LIANG, YING  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Acute;Aging;aging process;aging related;Amino Acids;Angiotensin II;BCL2 gene;Binding;Binding Proteins;Blood;Blood Cells;Bone Marrow;Bone Marrow Cells;Bone marrow failure;Bone Marrow Transplantation;Cancer Patient;cancer therapy;Carboxypeptidase;Carboxypeptidase A;cell injury;cell regeneration;Cellular Stress;Development;Dose;drug discovery;effective therapy;Elderly;Fluorouracil;functional decline;Funding;Genes;Genetic;genetic regulatory protein;Genetic Transcription;genome integrity;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;hematopoietic stem cell aging;hematopoietic stem cell self-renewal;Hematopoietic stem cells;Hematopoietic System;Hemorrhage;HMGB2 gene;Homing;Immune;In Vitro;in vivo;Induction of Apoptosis;Infection;inhibitor;Injury;Intervention;irradiation;knock-down;Knockout Mice;Knowledge;Lead;Legal patent;Life;Lymphoid;Maintenance;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Molecular;Mus;Myelogenous;Myelosuppression;Natural regeneration;NF-kappa B;novel;novel therapeutics;Older Population;Output;overexpression;Pathologic;Pathway interactions;Patients;PC3.1 antigen;Pharmacologic Substance;Pharmacy (field);Physiological;Population;preconditioning;preservation;prevent;Proliferating;Protein Subunits;Quality of life;Radiation;radiation mitigation;Radiation Protection;radiation response;Radiation therapy;Regenerative capacity;Regulation;Regulator Genes;Rejuvenation;Reporting;Ribosomal Proteins;Risk;Role;self-renewal;senescence;Signal Transduction;stem cell survival;stem cells;Stress;System;Therapeutic;Time;Transplantation;Up-Regulation;Work

PROJECT_TITLE: Latexin function in the maintenance and regeneration of the hematopoietic system

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Most diseases of the nervous system arise from aberrant function of neuronal circuits, but how individual neurons contribute to the function of larger networks is not well understood. This proposal will establish new methods to test the role of individual neurons and how they contribute to the function of a defined neuronal circuit. Success in these proposed experiments will reveal novel strategies used by neuronal circuits to support brain function, behavior, and perception as well as a better understanding of how circuits can become dysfunctional in disease states.

PI_NAMEs: GOLDING, NACE L;GOODRICH, LISA  (contact);JORIS, PHILIP ;MCGINLEY, MATTHEW J

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Animals;Auditory;Auditory area;auditory pathway;Auditory Perception;Auditory system;auditory thalamus;awake;Axon;Behavior;Behavioral;Binding;Biological Models;biophysical analysis;Biophysics;Brain;brain cell;Brain imaging;Brain Stem;Cell Physiology;cell type;Cells;Cochlea;Cochlear nucleus;Code;Complex;Computer Models;Computing Methodologies;confocal imaging;data integration;Decision Making;Dendrites;Detection;detection platform;Disease;Ear;Electron Microscopy;Electrophysiology (science);Elements;Experimental Models;experimental study;Frequencies;Gene Expression Profiling;Goals;Head;Hearing;Image;In Vitro;in vivo;Individual;Inferior Colliculus;insight;Learning;Link;Methods;Midbrain structure;millisecond;Modeling;Molecular;Molecular Analysis;Morphology;Mouse Strains;multidisciplinary;Mus;Nervous System Disorder;neuronal circuitry;Neurons;novel strategies;Octopus;optogenetics;Output;parallel processing;patch sequencing;Pattern;Perception;Performance;Physiological;Physiology;Play;Population;Positioning Attribute;predictive modeling;Process;Property;Psychometrics;reconstruction;Resolution;response;Role;Sensory;sensory input;sensory mechanism;sensory system;Shapes;sound;spatiotemporal;Speech;spiral ganglion;Stimulus;Stream;Study models;success;Synapses;System;Testing;Thalamic structure;Time;tool;Training;transcriptome sequencing;Translating;Travel;two-photon;voltage;Whole-Cell Recordings;Work

PROJECT_TITLE: Single-Cell Computation in Auditory Brainstem and its Impact on Cortical Coding and Behavior


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Infectious Diseases;Orphan Drug;Precision Medicine;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE In the proposed study, we will examine the effectiveness of oral cefixime 400 mg twice-daily for 10 days (compared to injectable single dose benzathine penicillin G) in treating syphilis among people with and without HIV infection. The results of this clinical trial might identify cefixime as a novel alternative treatment for syphilis that is useful for people living with HIV infection, in patients with penicillin allergy or in settings of penicillin shortage. We will also describe predictors of syphilis treatment failure among people with and without HIV.

PI_NAMEs: KLAUSNER, JEFFREY DAVID (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Adherence;Aftercare;Allergic;alternative treatment;Antibiotic Therapy;Antibiotics;arm;Benzathine Penicillin;beta-Lactams;Biological Availability;California;Case Series;CD4 Positive T Lymphocytes;Cefixime;Ceftriaxone;Cell Count;Cephalosporins;Characteristics;Clinical;Clinical Markers;clinical research site;Clinical Trials;compare effectiveness;cost;Data;Data Collection;design;Development;Dose;Doxycycline;Early treatment;effective therapy;effectiveness evaluation;efficacy evaluation;Enrollment;experience;experimental arm;follow-up;Generations;HIV;HIV Infections;Human;Incidence;Individual;Infection;Injectable;Injections;instrument;International;Intramuscular;Macrolides;men who have sex with men;Monitor;novel;novel strategies;open label;Oral;Oral Administration;Oral cavity;Outcome;Participant;participant enrollment;Patients;Penicillin Allergy;Penicillin G;Penicillins;Persons;Peru;pharmacologic;Phase;Pilot Projects;Prediction of Response to Therapy;Pregnancy;Randomized;Recommendation;Recording of previous events;recruit;Regimen;Research;response;Review Literature;Serology;Serum;Site;study population;Symptoms;Syphilis;Tetracyclines;Time;Toxic effect;Training;treatment arm;treatment duration;Treatment Failure;United States Food and Drug Administration;Viral Load result

PROJECT_TITLE: Clinical Trial Comparing the Effectiveness of Cefixime Versus Penicillin G for Treatment of Early Syphilis

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative  Pioneer transcription factors can bind and open silent chromatin, leading to transcriptional activation. The pioneer factors Sox2 and Oct4 orchestrate cell-fate changes during development, yet how they selectively target and destabilize closed chromatin remains largely unknown. This project will investigate the molecular details of how Sox2 and Oct4 alter the structure and epigenetic state of chromatin, which will advance our mechanistic understanding of pioneering action and ability to manipulate stem cells for research and disease therapy.

PI_NAMEs: NIKOLOVA, EVGENIA NIKOLAEVNA (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;adult neurogenesis;Affect;B-DNA;Base Pairing;Binding;Binding Sites;Biochemical;Biological Assay;Cell Physiology;Cells;Chemicals;Chromatin;Chromatin Fiber;chromatin remodeling;Chromatin Structure;Chromosomes;cofactor;Collaborations;Complex;Data;Dependence;Deposition;Development;Digestion;Disease;DNA;DNA Methylation;DNA Packaging;DNA Polymerase II;DNA Sequence;DNA-Binding Proteins;Embryonic Development;embryonic stem cell;Enzymes;Epigenetic Process;Event;flexibility;Future;Gel;Gene Activation;Gene Expression;Gene Expression Regulation;Genes;genetic regulatory protein;Genetic Transcription;Genome;Genomic DNA;Goals;Histone H3;histone methylation;histone methyltransferase;Histones;Human;improved;In Vitro;in vivo;insight;Investigation;Kinetics;Link;link protein;Malignant Neoplasms;Mediating;Methods;Methylation;MLL gene;Modification;Molecular;Molecular Conformation;Monitor;Mutate;Mutation;N-terminal;Nervous System Disorder;NMR Spectroscopy;novel therapeutic intervention;Nuclear Magnetic Resonance;nuclease;Nucleic Acid Regulatory Sequences;Nucleosomes;Organism;Physiology;Play;pluripotency;Positioning Attribute;Post-Translational Protein Processing;preference;programs;Protein Dynamics;Proteins;Regulation;Resolution;RNA;Role;self-renewal;Signal Transduction;Site;Solvents;Somatic Cell;Stem Cell Research;Structure;Tail;Testing;therapeutic target;three dimensional structure;transcription factor;Transcription Initiation;Transcriptional Activation;Variant;Work;Writing

PROJECT_TITLE: Dissecting the Mechanisms of Pioneer Factor Facilitated Chromatin Opening

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Epilepsy affects millions of individuals globally. Among those affected, 30% suffer from untreatable recurrent seizures throughout life, putting them at high risk for post-ictal cardiorespiratory failure and unexpected death (SUDEP). The goal of this fellowship is to determine the role neuroinflammation plays in epilepsy pathophysiology to help identify novel therapeutic targets to prevent the consequences of uncontrolled seizures.

PI_NAMEs: OSMANI, WASIF A (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Address;Affect;Animal Model;anti-epileptic agents;Apnea;Architecture;Astrocytes;audiogenic seizure;Baroreflex;Bioinformatics;Biological Assay;BLR1 gene;Brain;Brain region;Brain Stem;Breathing;Cause of Death;CCL2 gene;Cell Nucleus;cell type;Cells;Cessation of life;chemokine;chemokine receptor;Chemoreceptors;Chronic;CXCL13 gene;cytokine;Data;DNA Sequence Alteration;Epilepsy;Event;Exons;experience;experimental study;Exposure to;Failure;Fellowship;Female;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genes;glial activation;Glial Fibrillary Acidic Protein;Goals;Health;Heart Arrest;Heart Rate;high risk;Hippocampus;Human;human data;IL1R1 gene;Impairment;Individual;Inflammatory;Inpatients;Interleukin-1;Intervention;Intractable Epilepsy;inward rectifier potassium channel;Knock-out;Knowledge;Lead;Life;Ligands;male;Mediating;Mediator;Medical;Microglia;Modeling;Molecular;Monitor;Morphology;mortality;Nerve Degeneration;neural circuit;neural network;neuroinflammation;Neurologic;Neuronal Dysfunction;Neurons;new therapeutic target;novel;Nuclear RNA;Nucleus solitarius;Pathologic;Pathway Analysis;Pathway interactions;patient population;Patients;Pattern;Peptide Hydrolases;Persons;pharmacologic;Play;Potassium Channel;preBotzinger complex;prevent;Prevention;Proteins;Protocols documentation;PTGS2 gene;Publishing;raphe nuclei;Rattus;receptor;receptor function;Recurrence;respiratory;Respiratory physiology;Risk;Rodent Model;Role;Seizures;Serotonin;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;sound;sudden unexpected death in epilepsy;System;Testing;Tissue-Specific Gene Expression;Tissues;Tonic - clonic seizures;transcriptome sequencing;transcriptomic profiling;transcriptomics;zinc finger nuclease

PROJECT_TITLE: Investigating the role of brainstem neuroinflammation in cardiorespiratory control in a rat model of recurrent epilepsy


ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Nanoparticle therapeutics are a promising therapeutic modality that are used clinically to treat a variety of diseases in different tissues, but their successful application requires precise delivery to target sites. Integrating our expertise in nanoparticle design and cell engineering, we will develop living cell inspired systems to improve the delivery of nanoparticle therapeutics by mechanistically understanding how the interface between living cells and nanoparticles impacts the migration of carrier cells and transport of nanoparticle, identifying ideal delivery parameters for engineering living cell as drug delivery carriers, and creating multiscale strategies to enable delivery to specific cells. As such, this project has the potential to positively impact public health by developing new ways to deliver and improve the biological outcomes of nanoparticle therapeutics and other therapeutics.

PI_NAMEs: ZHAO, ZONGMIN  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TITLE: Multiscale approaches to engineering  living cells for nanotherapeutic delivery

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative  (Relevance to Public Health)  This proposal follows a unique sample from age 13 to 37 to examine adolescent peer and family experiences as long-term predictors of key physical health and aging outcomes in early midlife. The project has strong relevance to public health in that it will allow us to identify adolescent-era roots of key outcomes in adulthood ranging from specific health outcomes (e.g., cardiovascular disease risk and metabolic illness) to more fundamental patterns of physiological and epigenetic aging. Results are expected: a. identify several entirely new arenas within adolescence for potential interventions to promote lifelong health and healthy aging; b. suggest specific relational characteristics to target across this period in screening and preventive interventions; c. distinguish social processes in adolescence that directly predict accelerated aging (and are thus critical to address within adolescence) from those that lead to mediated chains of risk (which would suggest multiple promising points of intervention); and d. dramatically advance our overall theoretical understanding of the ways in which early relationship difficulties are linked to and potentially affect physical health and aging outcomes well into midlife.

PI_NAMEs: ALLEN, JOSEPH PATRICK (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;Affect;Age;age acceleration;age effect;Aging;aging process;Biological;Biological Factors;Biological Markers;Body Weight;cardiovascular disorder risk;Characteristics;Child Rearing;Chronic;Conflict (Psychology);contextual factors;Data;Demographic Factors;density;early childhood;emerging adult;epigenetic aging;Ethnic Origin;experience;Family;Family Relationship;follow-up;Future;Health;Health behavior;Health Promotion;healthy aging;Hostility;Individual;Interruption;Intervention;Interview;Knowledge;Life;Life Cycle Stages;Link;Measures;Mediating;Mediation;Mediator;Mental Health;Metabolic;middle age;Nature;Outcome;Parents;participant observation;Pattern;peer;physical conditioning;Physiological;Preventive;preventive intervention;Process;Public Health;Race;Risk;Risk Behaviors;Risk Factors;routine screening;Sampling;screening;sex;Smoking;social;Social Processes;social relationships;Social support;sociodemographics;stressor;Symptoms;Time;Weight;Work

PROJECT_TITLE: Social Relationship Qualities as Predictors of Health & Aging from Adolescence through Mid-Adulthood


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DETROIT

ORG_NAME: HENRY FORD HEALTH SYSTEM

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because our approach will establish the mechanism of disease progression in fatal cerebral phenotype of X-linked adrenoleukodystrophy, a genetic disorder that in 2016 was added to the federal Recommended Uniform Screening Panel of all genetic diseases recommended for state newborn screening programs. The identified metabolic pathways upon completion of the proposed research can be potentially translated to the clinical laboratory setting for drug development. The proposed research is relevant to the part of the NINDS mission that pertains to acquiring and using fundamental new knowledge of the nervous system to decrease the burden of neurological disease.

PI_NAMEs: SINGH, JASPREET  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Accounting;Address;Adrenoleukodystrophy;Adrenomyeloneuropathy;Allogenic;Amino Acids;Area;Astrocytes;Autologous;Automobile Driving;Autopsy;axonopathy;Benign;Biochemical;Body Fluids;Brain;Brain Diseases;Cells;Cerebrum;Citric Acid Cycle;Clinical;Clinical Course of Disease;clinical development;clinical predictors;comparative;CRISPR/Cas technology;cytokine;Data;Defect;Demyelinations;Development;Diagnosis;Disease;disease phenotype;Disease Progression;Distant;DNA Sequence Alteration;Drug Design;drug development;effective therapy;Energy Metabolism;expectation;Exposure to;Female;Fibroblasts;forging;Genes;Genetic Diseases;Genotype;Glucose;Glycolysis;Goals;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;improved;in vivo;Inborn Errors of Metabolism;induced pluripotent stem cell;Inflammatory;Inflammatory Response;Inherited;innovation;Investigation;Knock-in;Knowledge;Laboratories;Life;Link;male;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;metabolomics;Mission;Mitochondria;mitochondrial dysfunction;Modeling;motor disorder;Mutation;National Institute of Neurological Disorders and Stroke;Neonatal Screening;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;Neurons;new therapeutic target;novel;Patients;peroxisome;Phenotype;Plasma;Procedures;prognostic indicator;Protein Import;Public Health;Recommendation;Regulation;Reporting;Research;Respiration;response;Risk;Role;screening panel;screening program;Siblings;Source;Specific qualifier value;Sphingolipids;Spinal Cord Diseases;stem cell gene therapy;Stimulus;Supplementation;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcriptome;Translating;Up-Regulation;Very Long Chain Fatty Acid;white matter

PROJECT_TITLE: Use of IPSC to define role of astrocytes in specifying risk for onset of cerebral adrenoleukodystrophy

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Genetics;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Serious Mental Illness

PHR: PROJECT NARRATIVE The research proposed here will contribute to an understanding of major depressive disorder, the commonest psychiatric disorder and a leading cause of disability throughout the world. The proposal will combine information from voice recordings and genetics to identify subtypes of depression and develop robust predictors of mood, severity of illness and other clinical indicators. Our research will thereby provide new insights into disease, and well enable the more effective targeting of therapy to those who will most benefit at the appropriate time.

PI_NAMEs: FLINT, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: accurate diagnosis;Affect;Alleles;Anxiety;Behavioral;biobank;Biological Markers;Biology;Case/Control Studies;China;Chinese;Classification;Clinical;clinical application;Clinical Management;clinical phenotype;clinical translation;Collection;comorbidity;computer science;Data;Data Set;data sharing;deep neural network;Depressed mood;Development;Diagnosis;disability;Disease;Disease remission;disorder subtype;Drug Prescriptions;effective therapy;efficacy evaluation;Engineering;Far East;flexibility;Frequencies;Frustration;Genetic;genetic architecture;genetic information;genetic predictors;Genetic study;Genomics;Genotype;Heritability;Heterogeneity;improved;innovation;insight;Interview;Linkage Disequilibrium;long short term memory;Major Depressive Disorder;Manuals;Maps;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;Modeling;Moods;Morphologic artifacts;multidimensional data;Neurobiology;neuroimaging;Participant;Patients;Pattern;Persons;Pharmacological Treatment;Phenotype;Population;preservation;Psychiatry;public health priorities;Recurrence;Refractory;Research;Resources;Sampling;Scheme;Severities;Severity of illness;Signal Transduction;Specificity;Speech;statistics;suicidal;System;targeted treatment;Testing;Time;trait;transfer learning;Translational Research;treatment response;vector;Voice;Voice Quality;Woman

PROJECT_TITLE: Combining Voice and Genetic Information to Detect Heterogeneity in Major Depressive Disorder

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from 24 locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: NORTON, ELIZABETH SPENCER;WAKSCHLAG, LAUREN S (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Adverse event;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Caregivers;caregiving;Child;child bearing;Child Development;cohort;Communities;Conceptions;COVID-19;critical period;Data;Data Collection;Data Coordinating Center;data integrity;Data Set;data standards;design;Development;DNA;early experience;early life exposure;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Epigenetic Process;Ethics;Ethnic Origin;Event;experience;Exposure to;Feedback;General Population;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;Human;improved;Infant;Infection;innovation;insight;Life;Link;Location;Magnetic Resonance Imaging;Malnutrition;maltreatment;Marijuana;Maternal Health;maternal stress;Measures;Methods;Modality;Monitor;Mothers;multidimensional data;multimodality;neurodevelopment;neuroimaging;Newborn Infant;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Participant;Persons;Physiological;Population;postnatal;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal exposure;Process;protective factors;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;recruit;remote assessment;Research;Research Design;Research Personnel;Sampling;Second Pregnancy Trimester;Severities;Shapes;Site;socioeconomics;sound;Speed;stem;Stress;Structural Racism;substance use;Time;Time Study;Tobacco;tool;Toxicant exposure;Training;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: 9/24- Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-D(51)R]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Co-transcriptional and post-transcriptional control of RNA metabolism and fate requires the coordinated action of hundreds of RNA binding proteins. This proposal seeks to explore the biological function of a large set of predicted non-canonical RBPs that are enriched for neurological disease-associated nuclear- cytoplasmic transport factors. Characterization of this RNA-binding activity will expand the repertoire of human RBPs and define RNA regulatory networks disrupted in disease.

PI_NAMEs: BRANNAN, KRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Affinity Chromatography;ALS pathology;ALS patients;Alternative Splicing;Amyotrophic Lateral Sclerosis;Binding;Binding Proteins;Biological Process;Biology;Biomedical Research;Biotechnology;C9ALS;C9ORF72;Catalogs;Categories;Cell Nucleus;Cells;Code;Complex;Computing Methodologies;Cytoplasm;Disease;DNA Binding;Environment;experience;experimental study;Gene Expression;Genetic Transcription;genome-wide;genome-wide analysis;Goals;Guanosine Triphosphate Phosphohydrolases;Heart;Human;induced pluripotent stem cell;Life Cycle Stages;Maps;Mass Spectrum Analysis;Mediating;Mentors;Methods;Modeling;Molecular;motor control;Motor Neurons;mRNA Precursor;mutant;Mutate;Nervous System Disorder;Neurodegenerative Disorders;Nuclear;Nuclear Pore Complex;nucleocytoplasmic transport;Nucleocytoplasmic Transport Proteins;Pathology;patient derived induced pluripotent stem cells;Phase;Phenotype;Post-Transcriptional Regulation;programs;Protein Isoforms;protein protein interaction;Proteins;Proteomics;Publishing;RAN GTPase Activating Protein 1;RANGAP1 gene;Reporting;Research;Research Institute;Research Proposals;Resources;RNA;RNA Binding;RNA Computations;RNA metabolism;RNA Probes;RNA Recognition Motif;RNA Transport;RNA-Binding Proteins;RNA-Protein Interaction;Role;Running;Sensitivity and Specificity;sonar;stem cell biology;stress granule;Training;Training Programs;Transcript;transcription factor;transcriptome sequencing;Translations;Untranslated RNA;Validation

PROJECT_TITLE: Exploring functional complexes and disease networks within human RNA-binding protein interactomes

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Liver Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Adenoassociated virus vectors have potential for effective and safe gene therapy of a broad range of liver diseases for which current treatment options are lacking. To realize this potential, we will maximize the efficiency and specificity of therapeutic gene delivery to the target cell types in the human liver.

PI_NAMEs: WILLENBRING, HOLGER  (contact)

PROGRAM_OFFICER_NAME: BURGESS-BEUSSE, BONNIE L

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Bar Codes;Biliary;Capsid;cell type;Cells;Characteristics;cholangiocyte;Cholestasis;Clinical;Clinical Trials;Collagen;Development;Disease;DNA Sequence;DNA Shuffling;Dose;Dose Limiting;Engineering;Engraftment;fatty liver disease;Gene Delivery;gene therapy;Hemophilia A;Hepatic Stellate Cell;Hepatocyte;hepatocyte engraftment;Human;in vivo;Libraries;Liver;Liver diseases;Liver Fibrosis;Monkeys;Mus;Myofibroblast;next generation;Pathogenicity;Performance;Perfusion;Population;Reaction;Reporting;Safety;Satellite Viruses;screening;Side;single-cell RNA sequencing;Source;Specificity;Therapeutic;Therapeutic Effect;therapeutic gene;Toxic effect;Treatment Efficacy;vector

PROJECT_TITLE: Next-generation human liver gene therapy


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lung;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine

PHR: Project Narrative Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-mediated coronavirus disease (COVID-19) is an evolutionarily unprecedented natural experiment that causes major changes to the host immune system. We propose to develop a test that accurately predicts short- and long-term (within one-year) outcomes in hospitalized COVID-19 patients broadly reflecting US demographics who are at increased risk of adverse outcomes from COVID-19 using both clinical and molecular data. We will enroll patients from a hospitalized civilian population in one of the country’s largest metropolitan areas and a representative National Veteran’s population.

PI_NAMEs: BEENHOUWER, DAVID OWEN;DENG, MARIO C. (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;acute infection;adverse outcome;algorithm development;algorithm training;Algorithms;Area;Biological;Biological Markers;biomarker development;Blood;candidate identification;Cardiac;Cardiovascular system;Caring;Cessation of life;Clinical;Clinical Data;combinatorial;Complex;coronavirus disease;cost effectiveness;Country;County;COVID-19;COVID-19 impact;COVID-19 patient;COVID-19 risk;Data;Data Correlations;Death Rate;Decision Making;demographics;design;Diabetes Mellitus;Dimensions;Disease;Disease Outcome;experience;Family;frailty;Functional disorder;Futility;Gene Expression;Genes;Genomics;Geography;Goals;Health;Health Care Costs;high risk;Hospitalization;Immune system;Immunologics;improved;Inflammatory;information gathering;Los Angeles;male;Mediating;metropolitan;military veteran;Modeling;Molecular;Morbidity - disease rate;Multiomic Data;multiple omics;Natural experiment;Neurologic;New York;novel;Obesity;older adult;Organ;Outcome;outcome prediction;participant enrollment;Pathway Analysis;Pathway interactions;Patients;Pattern;people of color;Personal Satisfaction;Phenotype;Population;prediction algorithm;predictive test;Process;Prognosis;prognostic;Proteomics;Quality of life;Reporting;Research;Resource Allocation;respiratory;response;Risk;Role;Severity of illness;Site;symptomatic COVID-19;Symptoms;Testing;Texas;Therapeutic;Time;tool;Training;transcriptomics;Triage;Ventilator;Work

PROJECT_TITLE: Multi-Dimensional Outcome Prediction Algorithm for Hospitalized COVID-19 Patients

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Pediatric;Prevention;Primary Health Care;Substance Misuse;Underage Drinking

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative Simultaneous alcohol and marijuana (SAM) use is common among young adults and can lead to more negative consequences than use of either substance alone. No current intervention addresses SAM use and few leverage new technological methods or strategies to engage young adults. Using the Multiphase Optimization Strategy (MOST) framework, the goal of this project is to test the feasibility and efficacy of a new, fully mobile adaptive ecological momentary intervention on two outcomes (negative consequences and use of protective behavioral strategies) for young adults recruited from primary care clinics who are engaging in SAM use.

PI_NAMEs: PHILLIPS, KRISTINA T. (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Academic achievement;adaptive intervention;addiction;Address;Alcohol consumption;Alcohols;Behavioral;binge drinking;Brain;brief intervention;Cellular Phone;college;Communities;craving;design;Development;Ecological momentary assessment;efficacious intervention;emerging adulthood;Environment;experience;Experimental Designs;feasibility testing;Feedback;Frequencies;Future;Goals;handheld mobile device;Harm Reduction;Hawaii;Health;Health system;impaired driving performance;implementation intervention;improved;improved outcome;Individual;Individuation;Informal Social Control;Injury;interest;Intervention;Intervention Studies;marijuana use;Mental Health;Methodology;Methods;multiphase optimization strategy;Nature;new technology;Outcome;Participant;Persons;pilot test;Population;post intervention;prevent;preventive intervention;Primary Care;primary care clinic;primary care setting;Process;programs;psychoeducation;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;response;Risk;Risk Reduction;satisfaction;Site;smartphone application;social cognitive theory;Substance Use Disorder;substance use treatment;System;Technology;Testing;therapy development;Time;Treatment Efficacy;usability;Work;young adult

PROJECT_TITLE: Mobile adaptive intervention to reduce negative consequences associated with simultaneous alcohol and marijuana use in young adults in primary care

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Emergency Care;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BURNABY

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: SIMON FRASER UNIVERSITY

ORG_STATE: BC

ORG_ZIPCODE: V5A 1S6

PHR: PROJECT NARRATIVE The overdose (OD) crisis continues to devastate communities throughout North America. Although most overdoses are non-fatal, there is little knowledge concerning the health outcomes of people who experience a non-fatal overdose (NFOD). The proposed project will utilize administrative health data to provide insight into the role of sex, gender, and HIV status on the health outcomes of people experiencing an NFOD. This project will establish a Community Advisory Board, composed of people with diverse lived and living expert experiences, to provide guidance and ensure research soundness and relevance to the community. The results from this project will inform the direction and nature of subsequent community co-led research to answer relevant research questions and collaboratively explore barriers to care following an NFOD, which will ultimately support the development and implementation of relevant, and culturally appropriate services for cisgender women and gender minorities living with and without HIV who are affected by the OD crisis.

PI_NAMEs: HOGG, ROBERT S (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adult;Advocacy;Affect;antiretroviral therapy;barrier to care;British Columbia;Canada;Caring;Cause of Death;CD4 Lymphocyte Count;Cessation of life;Chronic;cis-female;cohort;Communities;community advisory board;comorbidity;comparative;Control Groups;Data;Data Set;Death Rate;Development;Disease;Drug usage;Emergency Health Services;Ensure;Epidemic;experience;Fatality rate;Funding;Future;Gender;gender difference;gender disparity;gender minority;General Population;Health;health care service utilization;health data;health difference;Healthcare;Healthcare Systems;High Prevalence;high risk;HIV;immunological status;Incidence;Individual;insight;interest;Knowledge;knowledge translation;Life Expectancy;Link;Literature;Longitudinal cohort;men;Morbidity - disease rate;mortality;National Institute of Drug Abuse;Nature;North America;opioid mortality;Outcome;Overdose;overdose death;Paramedical Personnel;Persons;Pharmaceutical Preparations;Policy Maker;Population;population based;Population Group;Process;Reporting;repository;Research;Research Priority;response;Risk;Role;Sampling;service utilization;Services;Severity of illness;sex;Sex Differences;social structure;sound;structural determinants;substance use;Suicide;Time;Time trend;Treatment outcome;trend;Underrepresented Populations;United States;Viral hepatitis;Woman

PROJECT_TITLE: The non-fatal overdose crisis: Sex and gender differences in healthcare utilization and health outcomes of people living with and without HIV between 2012 and 2020

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE We will investigate four newly identified eye and brain malformations – caused by large unique autosomal DNA insertions at the same chromosome Xq27 site – a palindromic `hotspot' near SOX3, which encodes a potent DNA-binding factor. The insertions harbor enhancer(s) that activate SOX3 in ectopic cells or compartments, homeotically trans- forming one embryonic tissue type into another (SOX3 gain-of-function). We will use patient-derived stem cells, in vitro differentiation, 3D chromatin interaction assays, and informative mouse models to test this hypothesis. Our study will throw light on blindness, brain disorders, human genetics, transcriptional regulation, mutation and evolution.

PI_NAMEs: GLASER, THOMAS M. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;9q21;Affect;Alleles;Anatomy;Anophthalmos;Anterior;Apoptosis;Architecture;arm;autosome;Bilateral;Biological Assay;Blindness;Brain;Brain Diseases;brain malformation;Cell Differentiation process;Cell Reprogramming;cell type;Cells;Cerebellar Ataxia;Cerebellum;Childhood;Choroid Plexus Epithelium;Chromatin;Chromosome Fragile Sites;Chromosomes;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coloboma;Constitution;Cornea;Cre driver;CRISPR/Cas technology;Defect;Development;differentiation in vitro;Disease;Disparate;DNA;DNA Binding;Drosophila genus;Ectoderm;Electroporation;embryo tissue;Embryonic Development;Enhancers;Epithelium;Evolution;Exhibits;Exons;Eye;Eye diseases;Female;gain of function;Genetic Transcription;Genome;Gonadal structure;Heterogeneity;Hi-C;histogenesis;Human;Human Genetics;Human Genome;in utero;Inheritance Patterns;Iris;Kinetics;Lens Placodes;Life;Light;Link;male;malformation;Meiosis;Methods;Microphthalmos;Modeling;Molecular;mosaic;mouse model;Mus;Mutation;nerve stem cell;neural;Neural tube;novel;Nucleotides;optic cup;Optic vesicle;Organ;Pathogenesis;Pathogenicity;patient - derived stem cells;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;photoreceptor degeneration;Photoreceptors;Positioning Attribute;prenatal;Prevalence;proband;programs;promoter;Purkinje Cells;Retina;retinal neuron;Retinal Photoreceptors;Retinitis Pigmentosa;Rod;Running;Series;sex;sex determination;Signaling Molecule;single-cell RNA sequencing;Site;Specific qualifier value;Specificity;Spinocerebellar Ataxias;Structure of retinal pigment epithelium;Surface;Syndrome;System;Techniques;Testing;Testis;Tissues;transcription factor;Transcriptional Regulation;transdifferentiation;Transgenes;Transgenic Mice;Visual Fields;X Inactivation

PROJECT_TITLE: Homeotic hotspot in the human genome for eye and brain disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative  The research will study how supporting cells called astrocytes and microglia are important to the loss of vision caused by the eye disease, glaucoma. The pressure in the eye affects these cells, leading to both good and toxic effects on the important nerve cells whose death is the cause of glaucoma blindness. Treatments that come from this work are envisioned that would preserve vision in a process called neuroprotection.

PI_NAMEs: QUIGLEY, HARRY ALAN (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Affect;Angiopoietins;Area;Astrocytes;Autopsy;Axon;axon injury;Axonal Transport;Behavior;Biochemistry;Biological Assay;Biomechanics;Blindness;Brain;Brain Diseases;Categories;Cell Death;cell injury;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chronic;Classification;Complex;computer studies;Connective Tissue;Cytoprotection;Cytoskeleton;Data;detector;Development;Dimensions;disease model;Elements;Evaluation;Extracellular Matrix;Eye;Eye diseases;ganglion cell;Gene Expression;Glaucoma;glial activation;high intraocular pressure;Histologic;Human;individualized medicine;inhibitor;Injections;Injury;Intervention;kinase inhibitor;Knock-out;Laminin;Lasers;Libraries;Life;Link;Liquid substance;Location;Measures;Mechanical Stress;Mechanics;Mediating;Membrane;Methodology;Microglia;Microscopic;Modeling;mouse model;Movement;Mus;nerve damage;neuronal cell body;Neurons;neuroprotection;neurotoxic;Obstruction;Optic Disk;Optic Nerve;Optic Nerve Injuries;Papillary;Pathogenesis;Pathway interactions;Phenotype;Physiologic Intraocular Pressure;Physiology;Play;preservation;pressure;Prevention;Process;protective effect;protein expression;Proteomics;Publishing;Rattus;Reaction;Report (document);Reporting;Research;response;Retina;Retinal Ganglion Cells;Rho-associated kinase;Role;Sclera;Severities;single-cell RNA sequencing;Site;Specific qualifier value;STAT3 gene;Stress;Structure;Supporting Cell;Testing;Therapeutic;therapeutic target;Thick;Tissues;Toxic effect;Transforming Growth Factor beta;Transgenic Mice;translaminar pressure gradient;Translating;Vision;Visual impairment;Work

PROJECT_TITLE: Pathogenesis of Glaucomatous Optic Nerve Damage

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Infant Mortality;Lung;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Sleep Research;Sudden Infant Death Syndrome

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The Sudden Infant Death Syndrome (SIDS) is a major cause of death in the first year of life for which there is no known cause. While our research strongly implicates defects in and reduced function of the life-sustaining brainstem serotonin system in a major subset of SIDS cases, the mechanisms underlying these defects remain unknown. We will test the hypothesis, directly in SIDS tissue as well as mechanistic validation in model systems, that neuroinflammation in the brain, originating from environmental factors (low oxygen or infections), causes or exacerbates the consequences of abnormalities within the serotonergic system and reduces the likelihood of successful recovery from reflex apneas (periods of breathing cessation). Confirmation of our hypothesis would guide new therapeutic strategies targeting neuroinflammation and aimed at prevention in a substantial group of SIDS infants.

PI_NAMEs: HAYNES, ROBIN LYNN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Affect;Age;Animal Model;Apnea;Autopsy;Back to Sleep;Biological;Biological Markers;Biological Models;Bradycardia;Brain;Brain Stem;brain tissue;Breathing;Cause of Death;Cell model;cell type;Cells;Cerebrospinal Fluid;chemokine;Chronic;Cluster Analysis;cohort;comparison control;cytokine;Data Set;Defect;Detection;Dinoprostone;Effectiveness;Embryo;Endothelial Cells;Engineering;Environmental Risk Factor;Event;experience;Failure;Functional disorder;Gene Expression;Gene Expression Profile;Granulocyte-Macrophage Colony-Stimulating Factor;Health;Histology;Human;human tissue;Hypoxia;IL17 gene;Impairment;In Situ Hybridization;in vivo;Incidence;Infant;Infant Mortality;Infection;Inflammation;Inflammation Mediators;Inflammatory;Injections;insight;Interleukin-1 beta;Interleukin-2;Interleukin-4;Intervention;intervention effect;Kynurenine;Life;Link;Lipopolysaccharides;Maps;Mediator;Molecular;Mus;Neopterin;Neuroglia;neuroinflammation;Neurons;normoxia;novel;novel therapeutic intervention;Oxygen;Pathology;Pathway interactions;Pattern;Physiological;Placental Insufficiency;Poly C;Poly I-C;post-natal intermittent hypoxia;postnatal;postneonatal mortality;Pregnancy;prevent;Prevention;Prevention strategy;preventive intervention;Protocols documentation;pup;receptor binding;Recovery;Reflex action;Research;Resolution;response;Risk;Risk Factors;Risk Reduction;RNA;Saline;Sampling;Serotonergic System;Serotonin;Serotonin Receptor 5-HT2A;single nucleus RNA-sequencing;Smoking;Source;Stress;stressor;success;Sudden Death;Sudden infant death syndrome;Testing;Tissues;Validation;Viral;Work

PROJECT_TITLE: Inflammatory stressors in serotonergic brainstem dysfunction and SIDS

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: Project Narrative The proposed Center for Collaborative Research in Health Disparities (CCRHD) at the University of Puerto Rico Medical Sciences Campus builds upon research resources developed under a previous RCMI-U54 grant and an extensive academic/community partnership to address health disparities affecting the Puerto Rican population. Translational research projects in the areas of basic biomedical, behavioral and clinical research, if successful, will provide different and innovative approaches to increase the capacity to conduct word-class research on diseases that disproportionally affect the Puerto Rican population by enhancing participation of Hispanic patients in clinical studies, partnering with community organizations and enabling all level of investigators to conduct health disparities research.

PI_NAMEs: FERNANDEZ-REPOLLET, EMMA  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Achievement;Address;Affect;Area;Attention;Basic Science;Behavioral;Behavioral Research;bioimaging;Bioinformatics;Biomedical Research;career;career development;Clinical Research;Collaborations;Communicable Diseases;community engagement;community organizations;community partnership;Data Science;Development;Disease;emerging tropical infectious disease;Ensure;Environment;Faculty;Fostering;Funding;Genomics;Goals;Grant;Health Disparities Research;health disparity;Health Sciences;Health Services;Hispanic;Hispanic Populations;improve minority health;Informatics;Infrastructure;innovation;Institution;instrumentation;Intervention;Medical;Mentors;minority health;minority health disparity;Minority Health Research;Monitor;Nature;neurogenomics;organizational structure;Outcome;Patients;Pilot Projects;Population;preservation;programs;Proteomics;Puerto Rican;Puerto Rico;Reduce health disparities;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Science;Services;Structure;tool;Translational Research;translational study;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative – Administrative Core As per RFA MD-22-002 instructions, this section is only required in the Overall Section.

PROJECT_TERMS: Accounting;Address;Advisory Committees;Affect;Area;Bioethical Issues;career;career development;Collaborations;commercialization;Committee Members;Communication;Communities;community organizations;Contracts;Core Facility;Data;Databases;Dedications;design;Development;Ensure;Equipment;Evaluation;experience;Fostering;Funding;Funding Opportunities;Goals;Grant;Health Disparities Research;health disparity;Human Resources;implementation evaluation;improve minority health;Individual;Infrastructure;innovation;Institution;Instruction;instrumentation;Intellectual Property;interest;Leadership;Licensing;Logic;Marketing;Measures;Medical;meetings;Mentors;minority health;minority health disparity;Minority-Serving Institution;Modeling;Monitor;multidisciplinary;Names;National Institute on Minority Health and Health Disparities;Online Systems;Outcome;physical separation;Population;Preparation;Process;programs;Publications;Puerto Rican;Puerto Rico;Reduce health disparities;Reporting;Research;Research Activity;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Science;Series;Services;Signal Transduction;skills;Structure;success;tool;Training Activity;Universities

PROJECT_TITLE: Administrative


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Microbiome;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Human papilloma virus (HPV) has been established as a causative agent of cervical cancer (CC), and Hispanic woman in Puerto Rico have the highest age-adjusted incidence compared to women in the US. Persistent infection with high-risk human papilloma virus (hr-HPV) types is a necessary, but not sufficient to cause cervical cancer. We hypothesize that the key factors that promote cancer progression likely reside in the cervical environment, notably its local multi-kingdom microbiome. Here we propose to comprehensively study crossectionally and longitudinally, the relationship between HPV, lower genital tract commensal bacteria and fungi, the metabolome and the immune response and cervical cancer.

PI_NAMEs: GODOY-VITORINO, FILIPA  (contact)

PROJECT_TERMS: Address;Affect;Age;Algorithms;Atopobium vaginae;Bacteria;Bioinformatics;biomarker identification;Biopsy;Caribbean region;Cervical;Cervical dysplasia;cervicovaginal;cervicovaginal microbiome;chronic infection;Clinical;co-infection;cofactor;Cohort Studies;commensal bacteria;Communities;Cross-Sectional Studies;cytokine;Cytology;Data;Death Rate;Development;Disease;disease phenotype;Disease Progression;Dysplasia;Environment;Etiology;Female;follow-up;Foundations;fungus;Gardnerella vaginalis;Genes;Genome;Genomics;Goals;health disparity;High grade dysplasia;high risk;High Risk Woman;Hispanic Populations;Hispanic Women;host microbiota;host-microbe interactions;HPV negative;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papillomavirus;Immune;Immune response;Immunologic Markers;Incidence;Inflammation;inflammatory marker;Integration Host Factors;intraepithelial;Joints;Lactobacillus;Latin America;Lesion;lifestyle data;Link;Longitudinal Studies;Low risk HPV;Machine Learning;machine learning model;Malassezia;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Metabolic;metabolic profile;metabolome;metabolomics;Metagenomics;Microbe;microbial;Microbial Taxonomy;microbiome;Molecular;multidisciplinary;multiple omics;new therapeutic target;novel;Outcome;Participant;Pathogenesis;Pathway interactions;Patient Selection;Persons;Phenotype;Pilot Projects;Population;predictive modeling;Predictive Value;premalignant;Prevalence;Puerto Rico;reproductive tract;Research;Risk;Risk Factors;Role;Sampling;Shotguns;Squamous intraepithelial lesion;Technology;Testing;tumor progression;United States;Vaccination;vaginal microbiome;Virus;Woman;Women's Group;Work;Yeasts

PROJECT_TITLE: The Microbiome as a risk factor for hr-HPV persistence and Cervical Cancer


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Pediatric;Pediatric Cancer;Rare Diseases

PHR: PROJECT NARRATIVE This research focuses on acute myeloid leukemia (AML), which affects more than 10,000 Americans annually, the majority of who die of their disease within a short time. This research addresses the role of SHP2 in receptor tyrosine kinase signaling in relapsed/refractory AML and the use of SHP2 inhibitors in combination with BCL2 inhibitors in AML treatment. The overall goal of this work is to establish new and effective strategies to treat relapsed/refractory AML.

PI_NAMEs: SMITH, CATHERINE CHOY (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Adhesions;Affect;American;Anoikis;Apoptosis;Apoptotic;Bcl-2 Homology Domain;BCL2 gene;Biochemical;Biological Markers;cancer cell;Cell Death;Cell Death Induction;Cell Survival;Cells;Clinical;clinical development;clinical efficacy;Clinical Trials;Combined Modality Therapy;Data;Dependence;Development;Disease;disease model;efficacy evaluation;efficacy testing;Epithelial Cells;Extracellular Matrix;FLT3 gene;Future;Genes;Genetic;genetic signature;Genetic Transcription;Goals;Growth Factor;Human;improved outcome;in vivo;inhibitor;inhibitor therapy;Knowledge;leukemia;leukemia treatment;Leukemic Cell;Measures;Mediating;Methods;Mitogen-Activated Protein Kinases;Modeling;Molecular;Molecular Conformation;multiple omics;mutant;Mutation;Newly Diagnosed;novel;Oncogenic;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;preclinical efficacy;preclinical trial;Prognosis;programs;Protein Family;Protein Tyrosine Phosphatase;Proteins;Proteomics;Proto-Oncogenes;PTPN11 gene;Receptor Protein-Tyrosine Kinases;Refractory;Relapse;relapse patients;Research;Resistance;Resistance development;resistance mechanism;response;response biomarker;Role;Signal Pathway;Signal Transduction;single cell sequencing;small molecule;Solid Neoplasm;synergism;Therapeutic;therapeutic evaluation;therapeutically effective;Time;Transcriptional Activation;Treatment Efficacy;treatment strategy;Tyrosine Kinase Inhibitor;Up-Regulation;Work

PROJECT_TITLE: Investigating the mechanism of SHP2 and BCL2 Inhibition in Acute Myeloid Leukemia (AML)


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE The Ending the HIV Epidemic Initiatives has the goal of reducing new HIV infections among at risk groups in priority jurisdictions. We propose the creation of ConPrEP; a behavioral intervention to increase PrEP uptake among latino men who have sex with men in Puerto Rico. The proposed study will allow for a comprehensive understanding of what are the best practices for interventions focused on PrEP uptake among Latino MSM in Puerto Rico. It will also provide for the development of a culturally congruent HIV prevention intervention to reduce new HIV infections among Latinos in Puerto Rico.

PI_NAMEs: MALAVE-RIVERA, SOUHAIL M (contact)

PROJECT_TERMS: Affect;AIDS prevention;Appointment;Area;Awareness;behavior change;Behavior Therapy;black men who have sex with men;care outcomes;Caring;Clinic;Collaborations;community partners;Comparative Effectiveness Research;comparative effectiveness study;compare effectiveness;comparison control;comparison intervention;Consolidated Framework for Implementation Research;Continuity of Patient Care;Control Groups;COVID-19 pandemic;Data;design;Development;Education;effectiveness evaluation;efficacy testing;Eligibility Determination;Epidemic;evidence base;experience;Geographic Locations;geographic population;Goals;Health;health care delivery;health disparity;Health Personnel;High Prevalence;HIV;HIV Infections;Human Resources;implementation evaluation;improved;Incidence;Infection;Intervention;intervention delivery;intervention effect;Intervention Studies;Interview;Latino;Latino Population;Managed Care;men who have sex with men;Mental Health;Methods;Modality;Modeling;motivational enhancement therapy;Outcome;Participant;patient engagement;Patient Self-Report;Persons;Phase;Population;Populations at Risk;pre-exposure prophylaxis;Prevalence;prevent;Preventive care;preventive intervention;Principal Investigator;programs;Puerto Rico;Randomized;Research;Risk Reduction;satisfaction;screening;service delivery;Services;social stigma;Spanish;Stigmatization;Subgroup;Techniques;Testing;therapy development;tool;transmission process;uptake;virtual

PROJECT_TITLE: Optimizing PrEP uptake among Latino MSM in Puerto Rico: A comparative effectiveness study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative - Relevance of Proposed Project to Public Health Milder forms of HIV-CI are prevalent in PWH and are at a higher risk to progress to worse stages, reiterating the importance of early diagnosis and possible treatment. We will explore the relationship between biological, behavioral responses and structural racism and discrimination (SRD) factors that position the Puerto Rican and Hispanics HIV population at a higher risk of developing HIV-CI. We expect that our findings will translate into interventions to improve Hispanic health and decrease the severity and prevalence of HIV-CI. Reducing SRD will improve health and reduce disparities.

PI_NAMEs: WOJNA, VALERIE  (contact)

PROJECT_TERMS: Address;antiretroviral therapy;Behavioral;behavioral response;Biological;Biomedical Research;Characteristics;chemokine;cohort;Criminal Justice;cytokine;Discrimination;Disease Progression;Disparity;disparity reduction;Early Diagnosis;economic indicator;Education;effective intervention;Effectiveness;Employment;Environment;Environmental Risk Factor;Epidemic;ethnic minority;Evaluation;Exclusion;Fostering;Geographic Information Systems;Health;health care availability;health care service utilization;health determinants;health disparity;health equity;health equity promotion;health literacy;Healthcare;high risk;Hispanic;Hispanic Populations;HIV;HIV Infections;HIV-associated cognitive impairment;Housing;human old age (65+);Immune;Impaired cognition;improve minority health;improved;Inflammatory;information system analysis;Institution;Intervention;Knowledge;Language;Mexican;Neighborhoods;Neurologic;Neuropathogenesis;Neuropsychology;New York City;Not Hispanic or Latino;novel;Older Population;Outcome;Patient Self-Report;Persons;Physical activity;poor health outcome;Population;Positioning Attribute;Prevalence;Public Health;Puerto Rican;Puerto Rico;racial discrimination;racial minority;Research;Risk;Role;Sampling;Severities;social deprivation;social stigma;Societies;Stress;Structural Racism;Subgroup;systemic inflammatory response;Testing;Translating;United States;Viral;Viral Load result;Virus Diseases;Woman

PROJECT_TITLE: Structural Racism and HIV-Associated Cognitive Impairment Among Hispanics


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Anhedonia, a core symptom of depression and other forms of psychopathology associated with severe negative health outcomes, including suicidality and poor treatment response, is a major public health concern. We will test an innovative positive emotion-focused preventive intervention for children and mothers with a history of major depression with anhedonia to enhance child reward responsiveness and prevent the emergence of anhedonia in youth. This study will advance understanding of how affective neuroscience can be translated into an experimental therapeutics approach to prevention, leading to more personalized interventions to reduce the burden of anhedonia and associated psychopathologies.

PI_NAMEs: BURKHOUSE, KATIE L;KUJAWA, AUTUMN J (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: 12 year old;Adult;Affect;affective neuroscience;Anhedonia;Behavioral;Biological;Brain;Buffers;Child;Clinical;clinical effect;Cognitive;Cognitive Therapy;comparison intervention;Data;depressive symptoms;design;Development;Diagnostic;Dose;Ecological momentary assessment;Effectiveness;Electroencephalography;experience;Family;Feedback;follow up assessment;follow-up;Health;high risk;Impairment;individualized prevention;innovation;interest;Intervention;Investigational Therapies;Life;Major Depressive Disorder;Measures;Mental Depression;Mental Health;Methods;Mothers;Motivation;National Institute of Mental Health;negative affect;neural;Neurosciences;Neurosciences Research;offspring;Outcome;Participant;personalized intervention;Phase;pleasure;Population;positive emotional state;Positive Valence;post intervention;precision medicine;prevent;Prevention;Prevention approach;preventive intervention;Process;prospective;psychoeducation;Psychopathology;Public Health;Randomized;Recording of previous events;Research Domain Criteria;response;Rewards;Risk;skills;suicidal;suicidal risk;symptomatic improvement;symptomatology;Symptoms;System;Testing;therapy resistant;Translating;treatment response;Work;Youth

PROJECT_TITLE: Reward Responsiveness as a Prevention Target in Youth At Risk for Anhedonia


PHR: Project Narrative – Investigator Development Core As per RFA MD-22-002 instructions, this section is only required on the Overall Section.

PI_NAMEs: QUIRK, GREGORY J (contact)

PROJECT_TERMS: Affect;Applications Grants;Area;Award;Behavioral;Cardiovascular system;career;career development;Clinical;Clinical Research;collaboratory;Communicable Diseases;Data;Development;Development Plans;Disease;Ensure;Evaluation;experience;Faculty;faculty mentor;Funding;Goals;Grant;Grant Review;Growth;health disparity;Health Services;HIV;innovation;Instruction;K-Series Research Career Programs;Malignant Neoplasms;Measures;Medical;meetings;Mentors;Metabolic Diseases;minority health;minority health disparity;minority trainee;Monitor;National Institute of Mental Health;Nervous System Disorder;NIH Center for Scientific Review;operation;Outcome;Pilot Projects;Population;professor;programs;Publications;Publishing;Puerto Rican;Puerto Rico;rehearsal;Research;Research Personnel;Research Proposals;Resources;Running;Science;Senior Scientist;Study Section;The Wistar Institute;Time;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: Investigator Development Core