NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T-cell therapies have emerged as a revolutionary advancement in the treatment of many advanced malignancies and have shown remarkable promise in a variety of non-malignant disorders. However, Cytokine Release Syndrome (CRS) represents a major cause of morbidity associated with CAR T-cell therapy. Enhancing the safety and efficacy of CAR T-cell therapy through the amelioration of CRS represents a significant unmet need, and it has the potential to dramatically improve outcomes and further expand the clinical application of CAR T-cell therapies.

PI_NAMEs: PUSIC, ISKRA  (contact)

PROJECT_TERMS: Adult;Affect;antagonist;arm;Autoimmune Diseases;B-Cell Lymphomas;Biological;Biological Assay;Blood specimen;Blood Vessels;cancer therapy;CAR T cell therapy;Cardiogenic Shock;Cell Physiology;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;clinical center;Clinical Trials;clinically significant;Collaborations;comorbidity;Correlative Study;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytokine Activation;cytokine release syndrome;Data;design;Disease;Dose;Double-Blind Method;Effectiveness;efficacy evaluation;Enrollment;experimental study;FDA approved;Fever;Functional disorder;Funding Opportunities;Goals;Hematologic Neoplasms;Hypotension;Hypoxia;IL-6 inhibitor;Immune;immune effector cell-associated neurotoxicity syndrome;Immunologics;Immunology;Improve Access;improved;improved outcome;In Vitro;in vivo;Incidence;Inflammatory;Infrastructure;inhibitor;insight;Institution;Interleukin-6;Libraries;Malignant - descriptor;Malignant Neoplasms;Mantle Cell Lymphoma;Modality;Morbidity - disease rate;Multiple Sclerosis;Non-Hodgkin's Lymphoma;Non-Malignant;novel;Oral;Outcome;Outpatients;patient response;Patient-Focused Outcomes;Patients;peripheral blood;Phase;phase 1 study;phase 3 study;PIK3CG gene;Placebo Control;Placebos;Population;preservation;prevent;Production;programs;Proliferating;prophylactic;Prophylactic treatment;protein kinase inhibitor;Randomized;randomized placebo controlled study;randomized, clinical trials;Reaction;Research;Research Personnel;Respiratory Failure;Safety;Serum;Severities;Site;Steroids;study population;T-Cell Receptor Therapy;Time;tocilizumab;Transgenic Organisms;transplantation therapy;treatment response;trial design;tumor;Universities;Washington

PROJECT_TITLE: Phase III, Multicenter, Randomized, Double-Blind Study of Duvelisib as Cytokine Release Syndrome Prophylaxis in Patients with Large Cell or Mantle Cell Lymphoma Undergoing CAR T-Cell Therapies


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Both HIV and Mycobacterium tuberculosis (Mtb) establish life-long infections that, despite the development of antiretroviral therapy and antibiotics, cause millions of deaths every year, emphasizing the need to develop a cure. This proposal aims to define the methods by which HIV and Mtb evade immune-mediated clearance by characterizing their common target cell, the macrophage, and how this cell acts to shield these pathogens from immune responses. Insight into these mechanisms will help identify macrophage-specific pathways that can be exploited to make these infected cells more susceptible to immune-mediated clearance, potentiating the development of cure-based strategies for HIV and Mtb infection.

PI_NAMEs: CLAYTON, KIERA L. (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Administrative Supplement;Antibiotics;antigen-specific T cells;antiretroviral therapy;Area;Award;Candidate Disease Gene;cell killing;Cells;Cessation of life;Characteristics;Chronic;Cytomegalovirus;Data;design;Development;Doctor of Philosophy;Future;Goals;Granzyme;HIV;HIV Infections;HIV/TB;Human;Immune;Immune Evasion;Immune response;Induction of Apoptosis;Infection;Inflammation;inhibitor;insight;Knock-out;Macrophage;Mediating;Methods;Mission;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;Natural Killer Cells;pathogen;Pathway interactions;Postdoctoral Fellow;Predisposition;prevent;Publishing;Research;Resistance;Supervision;T cell response;T-Lymphocyte;therapeutic development;Tuberculosis;Work

PROJECT_TITLE: Administrative Supplement: Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Human Genome;Liver Disease;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research will determine if or how a subset of liver cells which we recently discovered, contributes to liver scaring, inflammation, and immune regulation in alcohol-associated hepatitis, the disease with a high mortality rate and limited therapeutic options. Our ultimate goal is to apply newly gained information to the development of novel therapeutic approaches for this devastating disease.

PI_NAMEs: TSUKAMOTO, HIDEKAZU  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;AFP gene;Alcoholic Hepatitis;Alcoholic Liver Diseases;Attenuated;Cell Fate Control;Cell Lineage;Cells;Characteristics;Chronic;Cicatrix;Cirrhosis;Copy Number Polymorphism;CTNNB1 gene;CYP1B1 gene;Data;Death Rate;design;Development;Disease;Feedback;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic;Goals;Hematopoietic Stem Cell subsets;Hepatic Stellate Cell;Hepatitis;Hepatocyte;HNF4A gene;Human;immunoregulation;In Vitro;in vivo;Inflammation;Inflammatory;innovation;insight;Liver;Liver diseases;Liver Failure;Liver Fibrosis;liver inflammation;loss of function;Maintenance;Malignant neoplasm of liver;Mesoderm;Mitochondria;Modeling;Molecular;mortality;mouse model;Mus;Myofibroblast;Nodule;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;NR4A2 gene;Nuclear Orphan Receptor;Nuclear Proteins;overexpression;Parkinson Disease;Pathologic;Patients;pharmacologic;Phenotype;programs;promoter;regenerative;Regulation;Research;RNA;Role;Signal Induction;single cell analysis;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;single-cell RNA sequencing;Spottings;Testing;Therapeutic;Transcriptional Activation;transcriptome;transcriptome sequencing;Tumor Promotion;Up-Regulation;wound healing

PROJECT_TITLE: "CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis"

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: RENO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Project Narrative Inflammation is a major contributing factor in many leading causes of death, including heart disease and associated pathologies such as ischemia-reperfusion injury. Adhesion of neutrophils to the vessel wall, followed by infiltration into damaged tissues causes inflammation that is known to make injuries worse. This study will uncover new neutrophil adhesion mechanisms in inflammation, provide crucial insights into cell adhesion, and facilitate the development of novel drugs to limit tissue damage associated with inflammation.

PI_NAMEs: WEN, LAI  (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Address;Adhesions;Affinity;Amino Acids;Binding;Biological Assay;Blood;Blood Circulation;burden of illness;Cardiovascular Diseases;Cause of Death;Cell Adhesion;Cell membrane;cell type;cellular engineering;Cessation of life;Charge;chronic inflammatory disease;Data;Detection;Development;Disease;Endothelium;Event;Flow Cytometry;Goals;Heart Diseases;Image;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Injury;innovation;insight;Integrin alpha Chains;Integrin beta Chains;Integrins;intravital imaging;intravital microscopy;Kinetics;Knock-out;Knockout Mice;Lead;Leukocytes;live cell imaging;Macrophage-1 Antigen;Mediating;Microcirculation;Microfluidics;migration;Modeling;Molecular;Molecular Conformation;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;novel therapeutics;Outcome;Pathogenesis;Pathologic;Pathology;Persons;Pharmaceutical Preparations;pharmacologic;Phase;Phosphatidylinositide 3-Kinase Inhibitor;Physiological;prevent;Process;Proteins;quantitative imaging;recruit;Regulation;Reperfusion Injury;Reporter;Reporting;Research;response;Rest;Role;side effect;Signal Transduction;Site;Sodium Chloride;Tail;Talin;Testing;Tissues;trafficking;United States

PROJECT_TITLE: Molecular regulation of β2 integrin activation in neutrophil adhesion and inflammation

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: FAIRFAX

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: This pilot study evaluates associations between exposures to perfluoroalkyl substances (PFAS) and weight lost during a 10-week weight loss intervention among Hispanic children with overweight and obesity. We will quantify the association between 12 different PFAS measured in pre-intervention blood specimens collected from children at baseline and weight lost during the intervention, as well as with clinical biomarkers of metabolism, lipids and hormones measured in baseline blood specimens. The results will help to improve understanding of the impact of PFAS on weight loss in children with overweight/obesity, and will inform an R01 application to support a larger, more definitive and mechanistic future investigation of PFAS exposure and children’s weight loss.

PI_NAMEs: BLOOM, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Affect;Analytical Chemistry;Biological Markers;Biomedical Research;Biometry;Blood Pressure;Blood specimen;Body fat;Body mass index;Body Weight;Body Weight decreased;Child;clinical biomarkers;Communities;Data;density;Ensure;Environmental Risk Factor;Epidemiology;Exercise Physiology;experience;Exposure to;Future;Hispanic;Hispanic Populations;Hormones;improved;Intervention;intervention program;Investigation;Lipids;Lipoproteins;liver function;Measures;Metabolism;Not Hispanic or Latino;Obesity;obesity in children;obesity risk;obesogenic;Overweight;Parents;Pilot Projects;Poly-fluoroalkyl substances;post intervention;prospective;Public Health;Research;Serum;Weight;weight loss intervention;Youth

PROJECT_TITLE: Impact of Exposure to Perfluoroalkyl Substances on Weight Loss: A Pilot Study of Hispanic Children with Overweight/Obesity Participating in aCommunity-based Weight Loss Intervention Program


ADMINISTERING_IC: EY

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Studying the fundamentals of how retinal neurons and circuit ensembles respond to signaling deficits can provide valuable information as we seek to better understand and treat blinding diseases. This grant application proposes experiments that will deepen our mechanistic understanding of neural compensation in the retina and define the cellular and synaptic deficits of severe congenital stationary night blindness. The knowledge gained from these experiments will be applicable across neural circuits, as manipulation or replacement of integral circuit elements becomes leveraged for therapeutic advancements.

PI_NAMEs: KHOUSSINE, JACOB OMAR (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Action Potentials;Address;Adopted;Affect;Anatomy;Applications Grants;Architecture;Axon;Behavior;Behavioral;behavioral study;Biological Assay;Biophysics;blind;Brain;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Collaborations;Communication;Compensation;Complement;Confocal Microscopy;Coupled;Data;Disease;Electrophysiology (science);Elements;Equilibrium;experimental study;extracellular;Eye;Fostering;Functional disorder;ganglion cell;Gene Deletion;Generations;Genes;Genotype;Glutamate Receptor;Heterozygote;high resolution imaging;Human;Immunohistochemistry;improved;Inherited;insight;interest;Ion Channel;Knock-out;Knockout Mice;Knowledge;Light;luminance;Maps;Measures;Membrane;Metabotropic Glutamate Receptors;microscopic imaging;Modeling;Mus;mutant;Mutation;neural;neural circuit;neuromechanism;neuronal excitability;Neurons;neurophysiology;Neurotransmitter Receptor;Night Blindness;null mutation;Output;patch clamp;Pathway interactions;Patients;Pattern;Perception;Persons;Photoreceptors;Physiology;Process;Property;receptor expression;Research;Research Training;response;Retina;Retinal Diseases;Retinal Ganglion Cells;retinal neuron;Role;Signal Pathway;Signal Transduction;skills;Sodium Channel;Structure;Synapses;Therapeutic;Training;transmission process;Travel;Visual;visual information;Visual Perception;Visuospatial;voltage;voltage clamp;Work

PROJECT_TITLE: Mechanisms of neural compensation in the retina and dysfunction in congenital stationary night blindness


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The retina is an excellent model system for studying the function of specific neuronal subtypes within a circuit. This proposal uses a genetic approach to target a previously uncharacterized population of glycinergic amacrine cells to define their morphological properties and to test the hypothesis that this population provides inhibitory input to the direction selective circuit. It will also test whether the selective expression of Robo3 in this population is required for their proper development.

PI_NAMEs: MENN, ARIELLE  (contact)

PROJECT_TERMS: Affect;Amacrine Cells;Antibodies;axon guidance;Biological Models;Biotin;Candidate Disease Gene;Cell Separation;Cell Survival;Cells;Characteristics;Confocal Microscopy;Data;Data Set;Dendrites;density;Development;Electron Microscopy;Electrophysiology (science);experimental study;falls;Genetic;genetic analysis;genetic approach;Gold;Growth;In Situ Hybridization;Individual;inhibitory neuron;Inhibitory Synapse;Inner Plexiform Layer;Knock-out;Knowledge;Label;Membrane;Mitosis;Molecular Profiling;Morphology;mouse genetics;multimodality;Mus;nervous system development;neural circuit;Neurons;Neurophysiology - biologic function;patch clamp;Pattern;Population;Population Distributions;Population Sizes;postnatal;Property;prospective;receptor;Reporter;Resolution;response;Retina;retinal neuron;selective expression;Shapes;single-cell RNA sequencing;Specific qualifier value;starburst amacrine cell;Stratification;Structure;Study models;Synapses;synaptogenesis;Testing;Time;tool;Visual;visual processing;Work

PROJECT_TITLE: Genetic analysis of the Robo3+ glycinergic amacrine cell


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE A surprising revelation from the research on adaptation is that directional selection often generates significant functional diversity. In this proposal, I will test two mechanistic hypotheses in order to understand the fundamental reasons behind this peculiar phenomenon. This project will enhance our general understanding of adaptive processes and have implications for developing therapeutics for diseases that are caused by evolving entities, such as cancer and treatment-resistant pathogens.

PI_NAMEs: KHRISTICH, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: Adaptive Behaviors;anti-fungal agents;Awareness;Bar Codes;Behavior;Biological Assay;Biology;cancer therapy;Cells;Classification;Collection;combinatorial;Communities;Cyclic AMP-Dependent Protein Kinases;Data;Data Analyses;Data Set;Development;Disease;DNA;Doctor of Philosophy;Drug resistance;drug resistant pathogen;Effectiveness;Environment;Evolution;Exhibits;expectation;experimental study;Exposure to;fitness;Gene Expression;Generations;Genes;Genetic;Genome;genomic data;Genomics;Genotype;Glucose;Goals;Grant;Growth;Home environment;Individual;Infection;insight;Laboratories;Leadership;Learning;loss of function mutation;Malignant Neoplasms;Measurement;Measures;Methods;model organism;Molecular;Molecular Evolution;Molecular Genetics;molecular phenotype;mutant;Mutation;novel;Nutrient Depletion;Organism;Osmolar Concentration;pathogen;Pathway interactions;Pattern;Phase;Phenotype;Physiological;Physiology;Population Genetics;pressure;Process;Recurrence;Research;Research Personnel;Resistance;Resources;response;Saccharomyces cerevisiae;Signal Pathway;single-cell RNA sequencing;skills;Split-Pool Ligation Transcriptome sequencing;Technology;Testing;theories;Therapeutic;therapy development;Time;Training;transcriptome;transcriptome sequencing;transcriptomics;Writing;Yeasts

PROJECT_TITLE: Understanding the mechanism of diversity generation through directional selection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ADMINISTERING_IC: FD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEWARK

ORG_NAME: TRIPLE RING TECHNOLOGIES, INC.

PHR: Narrative This grant aims to improve predictability and reliability of radiation sterilization of medical devices by using com- puter modeling. Current standard of practice is to address sterilization once the product is fully developed as a manufactured device is needed. Our approach allows sterilizability to be assessed with a computer model of the device early in the development process, thereby lowering development cost and risk, facilitate regulatory deci- sion, and ultimately leading to lower cost and safer medical devices.

PI_NAMEs: FUNK, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: WILKICKI, KELLY

PROJECT_TITLE: Virtual dose mapping for radiation sterilization


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE  The mammalian genome is protected by an intricate network of host repair proteins that are responsible for maintaining the fidelity of the genetic code. Viral pathogens have evolved unique mechanisms to hijack these proteins to either cause cell death or long-term disease, but their mechanisms of action remain unknown. We propose to develop a research program that integrates cutting-edge genomic, proteomic and imaging technologies to dissect how host replication and repair proteins are usurped by DNA viruses, identifying new targets for therapeutic intervention to improve human health.

PI_NAMEs: MAJUMDER, KINJAL  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Bacteria;Bacteriophages;cancer therapy;Cell Death;Chemicals;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Repair Gene;DNA Viruses;Genetic Code;Genome;genome integrity;Genome Stability;Genomics;Goals;Health;Human;human DNA;Imaging technology;improved;Knowledge;Life Cycle Stages;mammalian genome;Mammals;Methodology;new therapeutic target;novel;Nuclear;pathogenic virus;Pathogenicity;Pathway interactions;programs;Proteins;Proteomics;Radiation;repaired;Research;Sentinel;Signal Transduction;Site;Surveys;Technology;Therapeutic Intervention;tool;Viral;Virus

PROJECT_TITLE: Defining how cellular DNA replication and repair machinery are hijacked by viral pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-D (55)]


NIH_SPENDING_CATS: Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Orphan Drug;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE This proposal will use rAAV-delivered and CRISPR-mediated gene editing in airway progenitor cells to permanently correct the defects in CFTR gene in cystic fibrosis patients. In addition, it will develop the next generation rAAV vector aligned with the gene editing approach in airway progenitor cells.

PI_NAMEs: QIU, JIANMING  (contact);YAN, ZIYING

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;adeno-associated viral vector;Adverse effects;Air;airway epithelium;Amino Acid Sequence;Basal Cell;Basement membrane;Biology;Capsid;Capsid Proteins;Cause of Death;Cell Culture Techniques;Cell Cycle;Cell Line;Cell Nucleus;cell type;Cells;Characteristics;chemotherapy;Chronic;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;conventional therapy;cost;CRISPR therapeutics;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis airway epithelia;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Defect;Dependence;design;Development;Directed Molecular Evolution;DNA Repair;dosage;Dose;Doxorubicin;effectiveness evaluation;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Epithelium;Evolution;Exons;Face;FDA approved;Ferrets;Financial Hardship;gene therapy;Gene Transfer;gene-editing approach;Genes;Genome;Genotype;Heterogeneity;Homeostasis;Host Defense;Human;Impairment;In Vitro;in vivo;Infection;insight;Integration Host Factors;Intervention;Introns;Ion Channel;Joints;Lead;Libraries;life span;Liquid substance;Lung;Lung infections;Mediating;Methods;Mitotic;Modeling;mutant;Mutation;mutation correction;N-terminal;Natural Immunity;Newborn Infant;next generation;novel;novel strategies;Nuclear;nucleocytoplasmic transport;Patients;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Physiological;Play;postmitotic;Productivity;progenitor;Proliferating;Property;Protocols documentation;Pulmonary Cystic Fibrosis;Recombinant adeno-associated virus (rAAV);reconstitution;Regulation;Regulator Genes;repaired;Reporter;Research;RNA Splicing;Role;screening;self-renewal;stem cells;success;Surface;Therapeutic;Therapeutic Effect;therapeutic genome editing;trafficking;trans-Golgi Network;transduction efficiency;Tropism;Variant;vector;Viviparous-1 protein

PROJECT_TITLE: Development of novel approaches for gene editing therapies of cystic fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The objective of this proposal is to identify inherited genetic variants non-coding RNA sequences that are associated with susceptibility to arsenic toxicity, and to understand their mechanisms. The successful identification of such variants will improve our understanding of the molecular mechanisms involved in host defense against and susceptibility to arsenic toxicities. The results of this study may improve identification of individuals at an increased risk of arsenic-induced lesions and provide candidate, therapeutic targets to decrease their risk of developing lesions after arsenic exposure.

PI_NAMEs: PIERCE, BRANDON LEE (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 3' Untranslated Regions;Affect;Arsenic;Bangladesh;Bangladeshi;Biological;career;Chronic;Consumption;contaminated drinking water;contaminated water;Dermatologic;Development;Disease;Elements;Environmental Health;Etiology;Exposure to;Genes;Genetic;Genetic Determinism;genetic epidemiology;genetic variant;Genome;Goals;health data;Host Defense;Human Genome;improved;Individual;Inherited;insight;Knowledge;Lesion;Longitudinal cohort study;Malignant Neoplasms;Messenger RNA;Metabolism;MicroRNAs;Molecular;Molecular Epidemiology;Morbidity - disease rate;Non-Malignant;Outcome;Participant;Pathway interactions;Persons;Poison;Poisoning;Population;Predisposition;Prevention strategy;Process;Public Health;Recording of previous events;Research;response;Risk;RNA Sequences;Severities;Single Nucleotide Polymorphism;skin lesion;therapeutic gene;therapeutic target;Toxic effect;Training;trait;Untranslated RNA;Variant

PROJECT_TITLE: Arsenic and the Human Genome:  susceptibility and response to exposure Supplement 4


ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Biomolecular condensate assembly is tightly regulated within cells, and failure to control condensate properties such as formation and dissolution has been linked to human disease. This research program will define biochemical and cellular mechanisms that dictate the regulation and function of biomolecular condensates in native cells. A detailed understanding of these molecular mechanisms is critical for furthering our understanding of how biomolecular condensate function in healthy cells and are dysregulated in human disease.

PI_NAMEs: FOLKMANN, ANDREW WILLIAM (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: absorption;Biochemical;Biochemical Process;Biochemical Reaction;Biochemistry;Biological;Caenorhabditis elegans;Cell Physiology;Cells;Cellular biology;Crowding;Cytoplasmic Granules;Cytosol;Development;Embryonic Development;Failure;Genetic;Goals;human disease;in vitro Assay;in vivo;interest;interfacial;Kinetics;Link;Measures;Modeling;Molecular;molecular mechanics;Nature;Phosphotransferases;Physical condensation;programs;Property;Regulation;Research;RNA;Stereotyping;Surface;Time;zygote

PROJECT_TITLE: Regulation and Function of Biomolecular Condensate

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Patient Safety;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chimeric antigen receptor T cells, or CAR T, are engineered white blood cells from patients that destroy cancer. CAR T has the potential to cure several blood cancers. However, side effects of CAR T can cause life-threatening problems with patients’ blood pressure, breathing, and brain. We will test a new approach to not only prevent these severe side effects, but also reduce cancer relapse after CAR T, by using the medications dexamethasone and anakinra.

PI_NAMEs: VASU, SUMITHIRA  (contact)

PROGRAM_OFFICER_NAME: DI FRONZO, NANCY L

PROJECT_TERMS: Acute Lymphocytic Leukemia;Address;Adult;Age;anakinra;Antibodies;Antigens;Aphasia;Arginine;arm;Autologous;Blood;Blood Pressure;Blood Tests;Bone Marrow;Bone Marrow Transplantation;Brain;Breathing;Cancer Patient;Cancer Relapse;CAR T cell therapy;Catabolism;CD19 gene;Cell Therapy;chimeric antigen receptor T cells;Clinical;Critical Care;cytokine release syndrome;Day Care;Delirium;Dexamethasone;Disease;Double-Blind Method;early phase trial;Eastern Cooperative Oncology Group;Eligibility Determination;Encephalopathies;Engineering;Exhibits;Fc Receptor;Ferritin;Fever;Glucocorticoids;Headache;health equity;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;High Dose Chemotherapy;high risk;Hispanic;Hospitalization;Hypotension;Hypoxia;Immune;immune effector cell-associated neurotoxicity syndrome;Immune system;Immunosuppression;Impairment;improved;Incidence;innovation;Interleukin 6 Receptor;Interleukin-1 Receptors;leukemia/lymphoma;Leukocytes;Life;Macrophage;Malignant Neoplasms;Mantle Cell Lymphoma;Measures;Metabolism;neurotoxicity;Non-Hodgkin's Lymphoma;Not Hispanic or Latino;novel strategies;Ohio;Organ;Outcome;Patient Monitoring;Patients;Pharmaceutical Preparations;Phase;phase II trial;Placebos;predict clinical outcome;prevent;Prevention;prophylactic;Prophylactic treatment;Prospective Studies;Randomized;Recurrent disease;Refractory;Relapse;relapse risk;Research;Risk;Risk Factors;Risk Marker;Risk Reduction;Safety;side effect;Signal Transduction;Stratification;success;System;T-Lymphocyte;Testing;tocilizumab;tool;Toxic effect;Universities;Work

PROJECT_TITLE: BMT Core- The Ohio State University blood and marrow transplant research consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-L (M1)]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Lung;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Bacterial lower respiratory tract infections are of great public health interest since they are a leading cause of mortality and morbidity in children. However, their genetic and immunological drivers in humans are, for the most part, unknown. We have identified the first cases of human TANK deficiency in patients with recurrent life- threatening bacterial lower respiratory tract infections and we will decipher the role that this molecule has in human immunity, B cell function and human disease.

PI_NAMEs: MARKLE, JANET G (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: 5 year old;Adaptor Signaling Protein;Address;Affect;Antibodies;Autoimmunity;autoinflammation;B-Cell Activation;B-Cell Development;B-Lymphocytes;biobank;Biological;Case Study;Cell Physiology;cell type;Cells;Cellular biology;Cellular Immunity;Child;Child Mortality;Clinical;Communicable Diseases;congenital immunodeficiency;consanguineous family;Critical Pathways;Cytometry;Data;Defect;Development;Diagnosis;Disease;disease phenotype;Electronic Health Record;exome sequencing;experimental study;Exposure to;Family;Future;Gene Silencing;Generations;Genes;Genetic;genetic approach;Genetic Polymorphism;genetic variant;global health;Health;Human;human disease;Immune;Immune response;Immune system;Immune System Diseases;immune system function;Immunity;Immunoglobulin Class Switching;Immunoglobulin Switch Recombination;Immunoglobulins;Immunologic Receptors;Immunologics;Immunophenotyping;Impairment;Individual;Infection;inhibitor;insight;inter-individual variation;interest;Knockout Mice;Knowledge;Learning;Life;Light;Link;Lower Respiratory Tract Infection;Mediating;Memory B-Lymphocyte;Mendelian disorder;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mutation;Nature;novel;pathogen;Pathway interactions;Patients;phenome;Phenotype;Plasmablast;Play;Pneumococcal Infections;Predisposition;prevent;Privatization;Production;protein expression;Public Health;rare genetic disorder;Recurrence;Reporting;Research;respiratory pathogen;Respiratory Tract Infections;reverse genetics;Risk;Role;Sampling;Signal Pathway;Signal Transduction;Stimulus;Streptococcus pneumoniae;Testing;tool;transcriptomics;Variant;Work

PROJECT_TITLE: Leveraging a novel human inborn error of immunity to understand B cell development and function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The objective of our study, Emergency Department-Initiated Medications for Alcohol Use Disorder (1R01AA030568-01), is to compare outcomes among emergency department patients with alcohol use disorder who are randomized to initiate treatment with naltrexone and gabapentin in the emergency department with compared with those randomized to usual care. The purpose of this supplement is to support the costs of conducting the study under IND status, as deemed necessary by the FDA.

PI_NAMEs: HAWK, KATHRYN  (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: Accident and Emergency department;Acute;addiction;Address;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;American;Automobile Driving;binge drinking;buprenorphine treatment;Caring;Categories;Characteristics;Chronic Disease;Client satisfaction;college;cost;cost effective;craving;Databases;drinking;Drug usage;effective therapy;Emergency Department patient;Emergency department visit;Emergency Department-based Intervention;Emergency Medicine;Enrollment;Ethnic Origin;Family;gabapentin;Gender;Guidelines;hazardous drinking;Health;Healthcare Systems;Heart Diseases;Heavy Drinking;housing instability;improved outcome;Individual;Infection;Injury;Inpatients;Insurance;Intervention;Interview;Malignant Neoplasms;Mediation;Medical;medication compliance;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;Naltrexone;novel;open label;opioid use;opioid use disorder;Outcome;Outpatients;Parents;Participant;Patients;Pharmaceutical Preparations;Pharmacotherapy;programs;Protocols documentation;psychosocial;Race;Randomized;randomized, clinical trials;Recommendation;Reporting;Respondent;screening, brief intervention, referral, and treatment;Societies;sociodemographics;Socioeconomic Status;Stroke;Surveys;Telephone;Tobacco;Tobacco use;treatment as usual;Treatment outcome;Withdrawal;Withdrawal Symptom

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Genetics;Lung;Pulmonary Fibrosis;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Degenerative lung diseases are adding significant burden to the health care in the United States. Currently there are no effective treatments and lung transplantation remains the best resource to improve lung function and survival. Understanding the genetic and cell biological mechanisms that initiate and promote disease pathogenesis in the aged lungs will aid in discovery of novel treatments to block or reverse these diseases.

PI_NAMEs: TATA, ALEKSANDRA  (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Address;age related;aged;Aging;Alveolar;alveolar epithelium;Area;Biological;Biological Assay;cell age;Cell Differentiation process;cell type;Cells;Chronic Obstructive Pulmonary Disease;Coculture Techniques;Confocal Microscopy;Data;Defect;Disease;Ectopic Expression;effective therapy;Electron Microscopy;Environmental Exposure;Epithelial Cells;epithelial repair;Etiology;Fibroblasts;Fluorescence;Functional disorder;Future;Gases;Genes;Genetic;genome wide association study;Goals;Healthcare;Homeostasis;Human;human disease;Image;Impairment;improved;in vivo;Injury;loss of function;Lung;Lung Diseases;lung regeneration;lung repair;Lung Transplantation;Maintenance;Mediating;Metabolic;Microtubule Bundle;Microtubule-Associated Proteins;Microtubules;Mitochondria;Modeling;Morphology;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Natural regeneration;novel;old mice;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;pharmacologic;Phosphorylation;Pulmonary Emphysema;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Regenerative Medicine;repaired;Reporter;Resources;risk variant;Role;stem cells;Surface;tau dysfunction;tau expression;tau mutation;tau Proteins;tau-1;Testing;Therapeutic;therapeutic development;Thick;Thinness;Tissue imaging;Tissues;transcriptome;transcriptome sequencing;Tubular formation;Tubulin;two-dimensional;United States;Western Blotting;Work

PROJECT_TITLE: Tau Mediates Microtubule and Mitochondrial Dynamics to Control Cellular Organization and Alveolar Epithelial Repair

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: BETHESDA

ORG_NAME: U.S. NATIONAL INST ALCOHOL AB/ALCOHOLISM

ORG_STATE: MD

PHR: Project Narrative The ability to stop an action is essential for successfully navigating everyday life. Loss of this skill is a hallmark in many neurological disorders, including alcohol use disorder. Brain regions responsible for action control, like the globus pallidus (GPe), are sensitive to alcohol-induced changes, but the underlying complexity associated with this brain region and lack of detailed movement tracking have hindered a deeper understanding of the underlying mechanisms. This proposal describes experiments using new tools and high-resolution behavior analyses to define the neural basis of GPe activity both in states of health and disorder to further our understanding of how those experiencing alcohol use disorder struggle to inhibit their actions in relationship to their alcohol use.

PI_NAMEs: HAGGERTY, DAVID LEO (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Abstinence;Acute;addiction;Adult;Alcohol consumption;alcohol craving;alcohol effect;alcohol exposure;alcohol response;alcohol use disorder;alcohol use initiation;Alcohols;American;Animals;Behavior;Behavior Control;Behavioral;Behavioral Assay;binge drinking;Biological;Biosensing Techniques;Brain;Brain region;cell type;Cessation of life;Chronic;Corpus striatum structure;Darkness;Decision Making;design;Disease;Dorsal;drinking;drinking behavior;Electrophysiology (science);Elements;experience;experimental study;Exposure to;Failure;FOXP2 gene;Genetic Markers;Globus Pallidus;Goals;Head;Health;Heavy Drinking;high intensity drinking;Human;Image;Impulsivity;in vivo;in vivo imaging;insight;Interoception;Knowledge;Label;Laboratories;Life;Link;Locomotion;Maps;Measures;Modeling;Motor;motor behavior;motor control;Movement;Movement Disorders;mRNA Differential Displays;Mus;Nervous System Disorder;neural;neural circuit;neural correlate;Neurons;new therapeutic target;novel;novel therapeutics;Outcome;Pattern;Performance;Physiological;Play;presynaptic;Process;Property;psychologic;Recording of previous events;Relapse;Research;Resolution;response;Risk;Role;Signal Transduction;skills;Slice;Specificity;Technology;Testing;Time;tool;Training;Transgenic Mice;two-photon;Viral;Visualization;Walking;Work

PROJECT_TITLE: The role of Globus Pallidus externa (GPe) neuronal subtypes in the governance of alcohol response inhibition behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MK)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Mental Health;Mental Illness;Pediatric;Suicide

PHR: PROJECT NARRATIVE Our study is designed to respond to the adolescent mental health crisis, providing critical information about the role of Medicaid managed care organizations (MCOs) in providing mental health access and services for adolescents, the effects of MCO exits on continuity of care, and the implications on parents and adult caretakers of adolescents undergoing a mental health crisis.

PI_NAMEs: MCCONNELL, KENNETH JOHN (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Academy;Acute;Address;Administrator;Adolescent;adolescent mental health;Adolescent Psychiatry;Adult;Advisory Committees;Affect;Age;aged;American;Anxiety;Attention;Behavior;Caregivers;Caring;Characteristics;Child;Child Mental Health;Child Psychiatry;Childhood;Communities;Complex;Continuity of Patient Care;County;Coupled;Data;data management;Data Set;Depressed mood;design;Diagnosis;Emergency department visit;Emergency Situation;Enrollment;Event;experience;Face;Family;family support;Feeling;Feeling hopeless;Feeling suicidal;Female;flexibility;Grouping;Health Personnel;health service use;High School Student;Hospitalization;Improve Access;improved outcome;Incentives;Individual;informant;Information Systems;insight;Insurance Coverage;Interview;Managed Care;Marketing;Measures;Mediating;Medicaid;Mental Depression;Mental Health;Mental Health Services;Methods;novel;Organizational Models;organizational structure;Outcome;pandemic disease;Parents;Patterns of Care;Pediatric Hospitals;Pediatrics;Performance;Play;Policies;Positioning Attribute;Process;programs;Provider;Quality of Care;Reporting;Research;Resources;response;Role;service utilization;Services;Source;Stress;Structure;Students;Suicide;Surgeon;System;Testing;United States;Youth

PROJECT_TITLE: Adolescent Mental Health and the Role of Medicaid Managed Care

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Sexual and gender minority (SGM) couples in the U.S. in general wish to have children and grow their families; however, having children for SGM couples is complex and expensive. There is a relatively large literature on how factors like finances may affect parenting decisions for SGM couples but little research has looked at whether deciding when and whether to have children may also be influenced by the impacts of state and local laws and public opinions about SGM people. This proposal aims to understand multiple levels of influence on SGM couples' decision-making about whether and when to have children—and to examine changes over time.

PI_NAMEs: VELDHUIS, CINDY B (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adoption;Affect;Age;Alcohol abuse;Alcohol consumption;Area;Automobile Driving;Cardiovascular Diseases;cardiovascular health;Child;Child Rearing;cisgender;Climate;Complex;Couples;COVID-19 pandemic;Decision Making;Disparity;Economic Factors;Ethnic Origin;Exclusion;Face;Family;Family health status;family influence;Fertility Rates;Fostering;Gender;gender minority group;Geography;Goals;Health;health disparity;health disparity populations;Health Promotion;Heterosexuals;improved;Individual;Inequity;Institution;interest;Intervention;Interview;Investigation;Knowledge;Laws;Lesbian Gay Bisexual Transgender;Lesbian Gay Bisexual Transgender Queer;Life;Literature;marginalized population;Mental Depression;Mental Health;Methods;National Institute of Child Health and Human Development;Natural experiment;novel;Occupations;Parents;Personal Satisfaction;Persons;physical conditioning;Physiologic pulse;Policies;Politics;Pregnancy;prepregnancy;Process;prospective;Public Health;Public Opinion;Race;recruit;Reporting;reproductive;Reproductive Technology;Research;Resources;Sampling;Security;Sexual and Gender Minorities;sexual minority group;sexual minority health;social;Social Conditions;Social Environment;social factors;social stigma;sociodemographics;Spanish flu;Statutes and Laws;Stress;stressor;Surveys;Testing;Time;United States National Institutes of Health;Variant;Woman;Work

PROJECT_TITLE: Understanding multilevel predictors affecting family formation among sexual and gender minority couples

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Electronic Nicotine Delivery Systems;Tobacco

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: The proposed research is relevant to public health because it focuses on measuring the cellular effects of dihydroxyacetone (DHA) exposure in pulmonary and cardiovascular models to better understand the inhalation exposure effects of DHA. DHA generated by e-cigarettes is inhaled by vapers, enters cells, and is incorporated into metabolic pathways causing metabolic changes and mitochondrial damage. These changes will directly impact pulmonary and cardiovascular cell homeostasis, cause severe declines in cellular function, and may even induce cell death. This work will establish critical links between DHA exposure and disease for e-cigarette users.

PI_NAMEs: GASSMAN, NATALIE ROSE (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: absorption;Acute;Address;biomarker validation;Cardiovascular Models;Cardiovascular system;Cell Death Induction;Cell Physiology;Cells;Cellular Stress;Chronic;cofactor;cytotoxic;Dihydroxyacetone;Disease;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Epidemiology;Exposure to;Future;genotoxicity;Glycerol;Glycolysis;Goals;Homeostasis;Inhalation;Inhalation Exposure;innovation;kidney cell;Link;Lung;Measures;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;programs;Propylene Glycols;Protein Glycosylation;Public Health;Research;Signal Transduction;Skin;Skin tanning;stress reduction;Testing;Tissues;vaper;Work

PROJECT_TITLE: Dihydroxyacetone exposure induces metabolic reprogramming and mitochondrial dysfunction

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Mental Health;Pediatric

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative This study will investigate how adolescents’ social media use affects internalizing symptoms (depression, anxiety), using innovative experimental and longitudinal methods. Findings from this study will have immediate implications for supporting healthier social media use among youth, and for more effectively educating youth about social media’s effects on mental health.

PI_NAMEs: NESI, JACQUELINE  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 17 year old;Adolescence;Adolescent;Affect;Age;American Psychological Association;Anxiety;anxiety symptoms;Behavior;Belief;Caregivers;Clinical;Collection;Data;Data Collection;Depressed mood;depressive symptoms;design;Development;Dimensions;Education;effective intervention;Emotional;Environment;evidence base;experience;Experimental Designs;Feedback;Feeling;Feeling hopeless;Female;follow-up;Frequencies;Future;Gender;Health behavior;health belief;high risk;indexing;Individual;innovation;insight;Investigation;Longitudinal Studies;male;Measures;media use;Mediating;Mediation;Mediator;Mental Depression;Mental Health;Methods;Modeling;Modernization;Nature;novel;Outcome;Parents;Participant;Patient Self-Report;peer;Policy Maker;Procedures;Public Health;public health intervention;recruit;Reporting;Research;resilience;response;Risk;Sampling;Schools;Shapes;social media;Surgeon;Symptoms;Testing;TikTok;Time;tv watching;virtual;Visual;visual tracking;Work;Youth

PROJECT_TITLE: Adolescents' Social Media Use and Internalizing Symptoms: Mechanisms of Risk and Resilience

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative The Tufts IRACDA program provides comprehensive postdoctoral training for outstanding scientists who seek academic careers that combine cutting-edge research, teaching, and mentoring, while ensuring that our nation’s biomedical workforce is diverse. The structured training program provides scholars with tools needed to establish independent research programs, develop and deliver cutting-edge courses rooted in best pedagogical practices, and mentor diverse groups of students. By building teaching and research partnerships with three local institutions that serve students from a variety of racial, ethnic, and socioeconomic backgrounds, Tufts IRACDA will inspire the next generation of scientists and provide them with opportunities and experiences to launch impactful careers.

PI_NAMEs: MAGUIRE, JAMIE LYNN;MCVEY, MITCH  (contact);MOORE, CLAIRE L

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Admission activity;Advisory Committees;Applications Grants;Area;Biomedical Research;Boston;career;career development;Collaborations;community college;course development;Doctor of Philosophy;Educational process of instructing;Ensure;Evaluation;experience;Exposure to;Faculty;Feedback;Foundational Skills;Funding;Future;Goals;improved;innovation;Institution;Interview;Joints;Massachusetts;Mentors;Minority;Monitor;Outcome;Participant;post-doctoral training;Postdoctoral Fellow;Process;programs;Publications;Research;scaffold;Schools;Science;Scientist;student participation;Students;success;Surveys;Time;tool;Training;undergraduate research experience;Underrepresented Populations;Universities

PROJECT_TITLE: IRACDA at Tufts University

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (MS)]


NIH_SPENDING_CATS: Genetics

ORG_DEPT: DERMATOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Narrative. The main objective of this application is to understand the molecular mechanisms of how RNA- methylating enzyme complexes, RNMT/RAM and METTL3/METTL14, are regulated by post-translational modifications (PTMs). Protein semi-synthesis strategies will be used to install site-specific and stoichiometric PTMs, non-hydrolyzable mimics, and chemical probes to evaluate how these marks influence the structure and function of these complexes, impacts their cellular biology, and characterize the molecular machinery that modulates their presence. Results from these studies can pave the way for the rational design of new therapeutics to treat a variety of human disorders, including cancer.

PI_NAMEs: DEMPSEY, DANIEL R. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Arginine;Behavior;Biochemical;Biological;Biological Process;Biology;Cardiovascular Abnormalities;Cell Physiology;Cellular biology;Chemicals;Code;Complex;Defect;Development;Disease;Enzymatic Biochemistry;Enzymes;Family;Future;Gene Expression;Goals;Guanine;Human;Impaired cognition;Malignant Neoplasms;Mass Spectrum Analysis;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;Multienzyme Complexes;novel;novel therapeutics;nucleocytoplasmic transport;Phosphorylation;Post-Translational Protein Processing;Process;programs;protein degradation;protein function;Proteins;Pseudouridine;rational design;Reader;Regulation;Research;Research Personnel;RNA;RNA Caps;RNA methylation;RNA Splicing;Site;structural biology;Structure;System;Therapeutic Intervention;tool;Transcript;Translations;ubiquitin isopeptidase;ubiquitin-protein ligase;Ubiquitination;Viral Pathogenesis;Writing

PROJECT_TITLE: Molecular mechanisms of RNA methyltransferases.

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative The project aims to investigate the mechanisms of a novel age-related endogenous protein, activated protein C (APC) in the pathogenesis of Alzheimer’s disease (AD). This study elucidates the capacity of recombinant APC derivatives in protecting neurofunctions in AD via regulating glucose metabolism and inflammatory responses. The findings could lead to novel therapeutic strategies aimed at preserving the neurofunctions from AD in the elderly.

PI_NAMEs: LI, JI  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: abeta accumulation;activated Protein C;activated protein C receptor;Affinity;age related;Aging;aging related;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-Protein;Amyloid deposition;Anticoagulants;Attenuated;Autopsy;Behavior;behavior test;Behavioral;Binding;Bioenergetics;Biomedical Engineering;Brain;Cause of Death;Chronic;Cognition;Cognitive;cognitive capacity;Cognitive deficits;Complex;cytokine;Cytoprotection;Defect;Dementia;Deposition;effective therapy;EGF gene;Elderly;Electrophysiology (science);Energy Metabolism;Environment;Exhibits;extracellular;Flow Cytometry;Functional disorder;Generations;Glucose;glucose metabolism;glucose transport;Health;Hemorrhage;Homeostasis;Immunofluorescence Immunologic;Impairment;improved;Induced Neurons;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Knock-in;Macrophage Activation;Mediating;Memory Loss;Metabolic;Metabolic Pathway;metabolic rate;Microglia;Mitochondria;Molecular;mouse model;Mus;mutant;Myocardial dysfunction;Neurofibrillary Tangles;neuroinflammation;Neuronal Dysfunction;Neurons;neuroprotection;novel;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathologic;Pathology;Peptide Hydrolases;Plasma;Play;preservation;Process;Property;Proteinase-Activated Receptors;Proteins;Proto-Oncogene Proteins c-akt;Recombinants;Regulation;Reporting;Repression;response;Risk;Role;Senile Plaques;Signal Transduction;Site;Stains;Stroke;success;Symptoms;Synapses;Synaptic plasticity;systemic inflammatory response;tau Proteins;Testing;Therapeutic;therapeutic target;therapeutically effective;Trauma;United States;Work

PROJECT_TITLE: Activated Protein C Signaling in Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Palliative Care;Rural Health;Sleep Research;Social Determinants of Health;Telehealth

PHR: Project Narrative IMPACT: This project expands the reach of evidence-based cancer symptom cluster self-management to rural, underserved communities through a clinical trial. We leverage the power of technology to improve access via telemedicine and mHealth. An effective, accessible, brief alternative to medication-based symptom management is essential given the limited availability of palliative and psychosocial care for advanced cancer patients, especially in rural communities, and the impact of these symptoms on functional status, quality of life, and treatment tolerance.

PI_NAMEs: WELLS-DI GREGORIO, SHARLA MAELYN (contact)

PROGRAM_OFFICER_NAME: MOLLICA, MICHELLE A

PROJECT_TERMS: actigraphy;active method;Advanced Malignant Neoplasm;Aftercare;Age;Anxiety;Appalachian Region;Appointment;associated symptom;Behavioral;Behavioral Symptoms;biobehavior;Blinded;Cancer Patient;Caring;Clinical Trials;clinically significant;Cognitive;Cognitive Therapy;common symptom;Communities;comparison control;Comprehensive Cancer Center;Control Groups;COVID-19;design;Diagnosis;Diagnostic;Disease;Distress;Dose;Educational process of instructing;effectiveness evaluation;effectiveness study;effectiveness trial;Endocrine;Equation;evidence base;Evidence based treatment;Exercise;experience;Fatigue;flexibility;Frequencies;Functional impairment;functional status;Future;Gender;Geographic Locations;Goals;group intervention;Hormones;Hydrocortisone;Improve Access;improved;improvement on sleep;Inflammation;Inflammation Mediators;Inflammatory;innovation;Intervention;Learning Skill;Lung;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Mediator;Melanoma;Mental Depression;Methods;mHealth;mhealth interventions;mobile application;Mobile Health Application;Modeling;Modification;mortality;Motivation;Multiple Myeloma;Ohio;Outcome;Palliative Care;Participant;patient engagement;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;physical symptom;Physiological;pilot trial;Population;prospective;Prostate;psychologic;psychological distress;psychological symptom;Psychosocial Assessment and Care;Quality of life;Randomized;randomized effectiveness trial;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;reduce symptoms;Reporting;Research;Research Assistant;Research Support;response;Rewards;Rural;Rural Community;rural patients;rural underserved;Self Management;Severities;Site;Sleep;sleep difficulty;Sleeplessness;Stratification;Stress;success;survivorship;Symptom Burden;symptom cluster;symptom management;symptomatic improvement;Symptoms;Technology;Telemedicine;Testing;Theoretical model;Therapeutic Intervention;Time;time use;treatment effect;underserved community;Underserved Population;Universities;virtual;web app

PROJECT_TITLE: Randomized clinical trial of a telemedicine-mHealth symptom cluster intervention for advanced cancer patients: Increasing access in underserved rural communities

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M1)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Narrative Mycobacterium tuberculosis (Mtb) has been subject to antibiotic selection in human populations for almost 80 years. We have used population genomics to identify Mtb genes undergoing diversifying selection in clinical strain since the onset of antibiotics. By phenotyping isogenic Mtb strains engineered to carry clinically prevalent variants, we have uncovered a new form of altered drug susceptibility, a recovery phenotype that we call antibiotic resilience. Mtb strains with resilience mutations which are subject to a period of drug exposure recover and begin to grow significantly more rapidly than wildtype strains. We have identified clinically prevalent resilience mutations in four essential regulators and their binding sites; we further find that these regulators regulate each other in modulate expression of key cell growth and division genes. Here we will mechanistically dissect the transcriptional regulatory network underlying antibiotic resilience through three aims: (1) “Define the resilience regulatory response under drug and host relevant conditions” in which we will generate and transcriptionally profile Mtb strains with resilience mutations; (2) “Determine the mechanistic basis of network-associated transcription factor functions under drug- and host-relevant conditions” in which we will use biochemical and structural approaches to determine the functions of the regulators with novel mechanisms of action and the impact of the clinically prevalent variants; and (3) In mouse models, “Test the hypothesis that antibiotic resilience mutations allow Mtb to escape drug and host selection in vivo”. These studies will elucidate the genomic and protein changes underlying resilience, a clinically relevant, previously unrecognized form of drug escape in Mtb, and our findings may inform future treatment and surveillance strategies for TB.

PI_NAMEs: FORTUNE, SARAH  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;Address;Antibiotics;Bacteria;bacterial genetics;Binding Sites;Biochemical;Cell Cycle;Cell division;cell growth;Cell Survival;cell type;Cells;Cellular biology;Clinical;Clinical Research;clinically relevant;Data;defined contribution;DNA biosynthesis;DNA-Directed RNA Polymerase;Drug Exposure;Drug resistance;Drug resistant Mycobacteria Tuberculosis;drug sensitivity;Engineering;Exposure to;Fortune;Future;Gene Expression Profile;Genes;Genetic;Genetic study;Genetic Transcription;Genomics;Growth;Homeostasis;Human;Immune;improved;in vivo;insight;Intercistronic Region;knock-down;Knowledge;M. tuberculosis genome;Modeling;Molecular;mouse model;Mutate;Mutation;Mycobacterium tuberculosis;network models;novel;Oxidation-Reduction;Oxidative Stress;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;Predisposition;pressure;Proteins;Recovery;Regimen;Regulatory Pathway;Relapse;resilience;response;Reverse engineering;Risk Factors;Role;Series;Stress;Structural Biochemistry;structural biology;Structure;surveillance strategy;Survivors;System;Testing;Titrations;transcription factor;transcription regulatory network;Treatment Failure;Treatment outcome;treatment response;treatment strategy;tuberculosis treatment;Variant;Work

PROJECT_TITLE: Molecular basis of antibiotic resilience in Mycobacterium tuberculosis

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


NIH_SPENDING_CATS: Clinical Research;Hematology;Immunotherapy;Infectious Diseases;Precision Medicine;Sepsis

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The global burden of sepsis is concentrated in sub-Saharan Africa, where poor understanding of sepsis pathobiology is a fundamental barrier to the development of effective treatment strategies. The goal of this project is to stratify sepsis patients in Uganda into biologically driven and therapeutically relevant subtypes. Our results will inform design of the first precision medicine clinical trial of sepsis treatment in sub-Saharan Africa and improve sepsis treatment outcomes in high HIV-burden settings worldwide.

PI_NAMEs: CUMMINGS, MATTHEW JOHN (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: activated Protein C;adrenomedullin;Africa South of the Sahara;Automobile Driving;Biological;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Classification;Clinical;Clinical Trials;cohort;Communicable Diseases;comorbidity;Country;Critical Care;Critical Illness;CTLA4 gene;cytokine;Data;Derivation procedure;design;Development;Dimensions;effective therapy;endothelial dysfunction;Evidence based treatment;exhaustion;Flow Cytometry;functional disability;Functional disorder;global health;Goals;Health Priorities;high dimensionality;high risk;HIV;HIV/AIDS;HMGB1 gene;Hospital Mortality;Hospitalization;IL17 gene;IL18 gene;IL2RA gene;IL8 gene;Immune;immune activation;immune checkpoint;Immune response;Immunologist;Immunophenotyping;Immunotherapeutic agent;improved;Income;Individual;Infectious disease threat;Inflammatory;innovation;insight;intercellular cell adhesion molecule;Interdisciplinary Study;Interleukin-6;Machine Learning;Mediating;Mediation;Methods;Mission;Modeling;monocyte;mortality;National Institute of Allergy and Infectious Disease;Natural Killer Cells;NCAM1 gene;Organ;Outcome;pathogen;Pathway interactions;Persons;Physicians;Plasma;precision medicine;precision medicine clinical trials;Production;programmed cell death protein 1;Prospective, cohort study;proteomic signature;Proteomics;Regulatory T-Lymphocyte;Research Infrastructure;Research Institute;Research Personnel;Risk;Scientist;Sepsis;septic patients;Shock;Subgroup;Survivors;T-Lymphocyte;Therapeutic;Time;TNF gene;TNFRSF5 gene;Transcription Factor AP-1;transcriptome sequencing;Translating;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;Uganda;Universities;unsupervised clustering;Up-Regulation;Validation;Vascular Cell Adhesion Molecule-1;Virus;Whole Blood;Work;young adult

PROJECT_TITLE: Multidimensional and longitudinal immune profiling of sepsis in Uganda

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE The overall goal of this project is to develop an innovative, sensitive, specific, and more accessible spatial method to correlate metabolic changes associated with cellular manipulations. We propose combining multiple phasor approaches - the phasor approach to Fluorescence Lifetime Imaging (phasor-FLIM, for metabolic imaging), phasor approach to hyperspectral imaging (sp-phasor, protein expression/ membrane fluidity) and phasor approach to Fluorescence Correlation Spectroscopy (phasor-FCS, protein diffusion). This method will allow us to connect changes in one dimension (e.g., protein diffusion) to the changes in another (e.g., metabolism) in a pixel-wise manner.

PI_NAMEs: RANJIT, SUMAN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Behavior;Binding;biological systems;Biophysics;Cells;Diffusion;Dimensions;Etiology;experimental study;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;fluorescence microscope;Fluorescence Microscopy;Future;Goals;Image;imaging approach;imaging modality;In Vitro;innovation;instrumentation;Investigation;Light;Membrane Fluidity;Metabolic;metabolic imaging;Metabolism;Methodology;Methods;Microscopy;multi-photon;physical property;programs;Property;protein expression;Proteins;Research;Resolution;single molecule;Spectrum Analysis;Stimulus;System;Time;Tissues;Whole Organism

PROJECT_TITLE: Developing multiparametric fluorescence microscopy to connect metabolism with cellular manipulations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-F (55)]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Given that the median age of patients diagnosed with most hematologic malignancies is 65 or older, improving allogeneic blood and marrow transplantation (alloBMT) outcomes in older patients is critically important. Our preliminary data suggest clonal hematopoiesis (CH) in older alloBMT recipients is associated with significantly increased NRM. Detection of CH may add important prognostic information to current risk stratification strategies for older patient, and it may be possible to ameliorate the effects of CH.

PI_NAMEs: JONES, RICHARD J (contact)

PROJECT_TERMS: Address;Age;Allogenic;allotransplant;Antineoplastic Agents;Aplastic Anemia;Area;Assessment tool;Biological Markers;Biology;Blood;Bone Marrow Transplantation;Clinic;Clinical;clinical center;Clinical Trials;cohort;comorbidity Index;conditioning;Cyclophosphamide;Data;Detection;Development;Diagnosis;Disease;Dose;effective therapy;Exclusion;FLT3 gene;Funding;graft vs host disease;Hematologic Neoplasms;Hematopoiesis;Hematopoietic Stem Cell Transplantation;human old age (65+);improved;improved outcome;Institution;Laboratories;Life;Maintenance;Maintenance Therapy;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant Neoplasms;Measurable;Morbidity - disease rate;mortality;Multicenter Trials;Myelogenous;Myeloproliferative disease;Non-Malignant;older patient;Outcome;participant enrollment;Patients;post-transplant;Procedures;prognostic;programs;Prophylactic treatment;Recurrent disease;Regimen;Relapse;Residual Neoplasm;Risk Assessment;risk stratification;Role;Sickle Cell Anemia;standard of care;success;Supportive care;System;Toxic effect;Translational Research;Translations;Transplant Recipients;Transplantation;Transplantation and Immune System;treatment choice;tumor;Tumor Burden;tumor heterogeneity;Tyrosine Kinase Inhibitor;virtual;Work

PROJECT_TITLE: BMT Core - Johns Hopkins


NIH_SPENDING_CATS: Biotechnology

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE The biology of all multicellular organisms relies on the ability of individual cells to communicate with their neighbors, and breakdowns in cell-cell communication are inextricably linked to a broad range of diseases.This proposal outlines a plan for a careful and quantitative dissection of receptor protein oligomerization (clustering), a major class of cell-cell interactions that has been particularly difficult to study experimentally due to the small size and fleeting nature of such molecular clusters. Using Eph receptors in human cells as our primary model system, we plan to combine advances in optogenetics, genome editing, single-molecule fluorescence imaging, and high-throughput sequencing to simultaneously advance our understanding of Eph receptor biology and develop new strategies for probing key oligomeric transitions in living cells.

PI_NAMEs: BELYY, VLADISLAV  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Biochemical;Biological Models;Biological Process;Biology;Biophysics;Cell Communication;Cells;Communication;Development;Disease;Dissection;Embryonic Development;Ensure;Enzymatic Biochemistry;Eph Family Receptors;Event;Evolution;experimental study;Family;Family member;fluorescence imaging;genome editing;Health;High-Throughput Nucleotide Sequencing;Homo;Human;In Vitro;Individual;intercellular communication;interest;Light;Link;Malignant Neoplasms;Membrane;Microscopy;Molecular;Nature;Nerve Degeneration;Optics;optogenetics;Organism;Organoids;Outcome;Pattern;programs;protein oligomer;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Regulation;Research;response;Role;Side;Signal Transduction;single molecule;stoichiometry;Tissues;tool;Work

PROJECT_TITLE: Molecular mechanisms of Eph receptor signaling

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE Microbial keratitis, a leading cause of worldwide visual impariment, disproportionally affects people with lower socioeconomic status. The National Eye Institute’s strategic plan highlights the critical need for point-of-care strategies to diagnose microbial keratitis. The proposed research will create open-source novel machine-learning algorithms to identify causative organisms of microbial keratitis at the point-of-care, using low-cost images and data from geographically-diverse cases, and integrate this information into a decision tool to inform treatment decisions for patients.

PI_NAMEs: FARSIU, SINA ;WOODWARD, MARIA ANNEKE (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Acute Pain;Address;Affect;Algorithmic Analysis;Algorithms;behavior change;behavior change wheel;Blindness;Calibration;Capital;Classification;Clinical;Clinical Data;clinical decision-making;clinical imaging;clinical risk;Communication;Complex;Consensus;Cornea;cost;Data;Data Set;Decision Aid;Decision Analysis;Decision Making;deep learning;deep learning algorithm;Diagnosis;diagnosis standard;Diagnostic;Discrimination;Disease;diverse data;Emerging infection;Environment;Equity;Eye;fungus;Future;Geography;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Health system;Image;improved;India;Infection;Intervention;Keratitis;Knowledge;Laboratories;large datasets;Logistic Regressions;low socioeconomic status;machine learning algorithm;Measures;Medical;microbial;Modeling;Morphology;multidisciplinary;National Eye Institute;Neighborhoods;novel;open source;Organism;Outcome;Pain;patient stratification;Patient-Focused Outcomes;Patients;Performance;performance tests;Persons;pilot test;point of care;point of care testing;Polymerase Chain Reaction;Population Heterogeneity;Poverty;prevent;Probability;productivity loss;prototype;Recording of previous events;Research;Research Personnel;Resources;Risk Factors;Science;Scientist;side effect;Specialist;Strategic Planning;support tools;Technology;Testing;Theoretical Domains framework;tool;Ulcer;Uncertainty;user centered design;Visit;Visual;Visual impairment;Weight;Work

PROJECT_TITLE: Automated Quantitative Ulcer Analysis (AQUA): Diagnosing Organism Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_CITY: HADLEY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl substances (PFAS), which are widely used in non-stick, water-resistant, and stain- resistant coatings for consumer products may adversely impact bone health. We have an excellent opportunity to capitalize on pre-existing, prospectively collected data and biospecimens for an innovative exploration of whether PFAS affect fracture risk, bone mineral density, and markers of bone turnover using prospective data from three established cohorts. Our work may suggest vital opportunities for fracture prevention via reduction in use of these chemicals.

PI_NAMEs: REEVES, KATHERINE WHITNEY (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Acceleration;adjudication;Affect;Age;aged;Aging;American;Behavioral;bioaccumulation;Biological Markers;Biological Monitoring;Black race;Blood;Body Composition;bone;Bone Density;bone health;bone loss;bone metabolism;Bone Resorption;Bone structure;bone turnover;Cell Culture Techniques;chemical stability;Chemicals;Clinical Data;clinical research site;cohort;Cohort Studies;consumer product;cost;cost effective;Cyclophosphamide;Data;Data Pooling;drinking water;Enrollment;Environment;environmental chemical;Epidemiology;epidemiology study;ESR1 gene;Evaluation;Exposure to;Female;Fracture;fracture risk;Health;hip bone;Human;human old age (65+);human tissue;Individual;innovation;insight;Investigation;Laboratory Study;Lead;Link;Longterm Follow-up;male;man;Measures;Mediating;Mediation;men;Metals;novel;older adult;osteoblast differentiation;Osteogenesis;Osteoporosis;osteoporosis with pathological fracture;Participant;perfluorooctanoic acid;Persons;Poly-fluoroalkyl substances;Population;Population Heterogeneity;PPAR alpha;PPAR gamma;Prevalence;Prevention;prospective;Prospective cohort;Public Health;Race;racial diversity;Random Allocation;recruit;Reporting;Research;Research Design;Resistance;Sampling;Scanning;Serum;sex;Source;Stains;Study of serum;study population;Sulfate;Urine;Visit;Vitamin D3 Receptor;Water;Woman;Women's cohort;Work

PROJECT_TITLE: Serum PFAS and risk of fracture and bone loss

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE Lipids, or fats, play an important role in regulating how cells work; accordingly, when lipids are located in the wrong locations within a cell, devastating diseases can occur, like Alzheimer’s and Parkinson’s diseases. This proposal seeks to functionally characterize a novel protein that regulates transport of lipids within cells. We expect this work to provide new insights into the causes of lipid-related diseases and inform the development of new treatments for these disorders.

PI_NAMEs: BASHIRULLAH, ARASH  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adaptor Signaling Protein;Alzheimer's Disease;Animals;Binding;Biological;Biological Models;Biological Process;C-terminal;Carbon;cell growth;Cell membrane;Cell Physiology;Cell Survival;Cells;Defect;Development;Disease;Drosophila genus;Endoplasmic Reticulum;Eukaryotic Cell;Exhibits;Exocytosis;Face;Fatty acid glycerol esters;Functional disorder;Genetic;Genome;Goals;Homeostasis;human disease;Hydrophobicity;in vitro activity;insight;Knock-out;Label;Lipid Binding;lipid metabolism;lipid transfer protein;lipid transport;Lipids;Location;macromolecule;Maintenance;Membrane;membrane biogenesis;membrane flux;Membrane Lipids;Metabolism;Molecular;Mutation;N-terminal;Nitrogen;novel;novel therapeutics;Organelles;Oxygen;Parkinson Disease;Phenotype;Phosphatidylinositols;Physiological;Physiology;Play;Post-Translational Protein Processing;Property;Protein Family;protein function;protein transport;Proteins;Regulation;Rod;Role;Saccharomyces cerevisiae;Shapes;Signal Pathway;Site;Sulfur;Testing;Time;Work

PROJECT_TITLE: Analysis of Bulk Lipid Transport at Membrane Contact Sites

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE Enhancers are non-coding regulatory elements modulating gene transcription in human diseases. We will develop computational methods to dissect enhancer function through data integration and machine learning of eight epigenomic features across hundreds of human cell types. The findings will fill up missing enhancer profiles and generate tools to prioritize enhancers’ impacts in human diseases.

PI_NAMEs: TENG, MINGXIANG  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;algorithm development;Area;Binding;cell type;Chromatin;Computing Methodologies;connectome;Consensus;data integration;data quality;Disease;Dissection;DNA Sequence;Enhancers;epigenomics;Evaluation;experience;Gene Expression;Gene Expression Regulation;gene interaction;Genetic Transcription;Genomics;Goals;heterogenous data;histone modification;Human;human disease;Laboratories;Learning;Machine Learning;machine learning algorithm;machine learning method;Mutation;Phenotype;promoter;Quality Control;Regulatory Element;Research;skills;Statistical Methods;tool;transcription factor;Untranslated RNA;Work

PROJECT_TITLE: Dissecting enhancer function through integrative genomics

STUDY_SECTION: MRAF

STUDY_SECTION_NAME: Maximizing Investigators' Research Award - F Study Section[MRAF]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Allergic diseases such as asthma, hayfever, and food allergy are a growing public health problem. This grant supports the training of academic scientists and physician-scientists, preparing them for careers as investigators into the causes and treatments of these diseases, with the goal of improving diagnosis, prevention, and therapy of allergic diseases.

PI_NAMEs: BARRETT, NORA AMANDA;BOYCE, JOSHUA A (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Immunologic Basis of Resistance and Hypersensitivity

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed PAINT, Precise Area INtroduction and Transfection, technology will be a method for highly localized, versatile, efficient biochemical delivery for “direct-write” guided administration at single cell to multi-cell resolution. The utility of this novel approach to cell modification rests on its adjustable resolution, rapidity, versatility, and ease of use: PAINT permits the simple and quick production of heterogeneously modified samples, including in vitro cell and tissue cultures. This research is relevant to public health because it will enable the in vitro growth of realistic organoids useful for modeling human physiology and disease.

PI_NAMEs: ASHTON, RANDOLPH S;FEDOROV, ANDREI G (contact);KANE, RAVI S.

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Adoption;applied biomedical research;Area;Biochemical;Biological;Biomedical Engineering;Biomedical Research;Biomimetics;Cell Culture Techniques;Cell membrane;Cells;Chemicals;Cytoplasm;Data;Development;Devices;Disease;DNA;Engineering;engineering design;Excision;experimental study;flexibility;Gases;Growth;Heterogeneity;Human;human model;improved;In Vitro;in vivo;Injections;Liquid substance;Mechanics;Membrane;Methods;Microinjections;millimeter;Modification;molecular size;Mutation;nanoparticle;Needles;neural;new technology;novel;novel strategies;Nucleic Acids;operation;Organoids;Permeability;Physiology;Plasma;Process;Production;Proteins;Public Health;Research;Resolution;Rest;RNA;Sampling;scale up;skills;Spatial Distribution;System;targeted delivery;Technology;Thinness;Time;tissue culture;Toxic effect;Transfection;Viral;Virus;Withdrawal;Writing

PROJECT_TITLE: Guided Intracellular Delivery using Precise Area Introduction and Transfection (PAINT)

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Nearly every step of HIV-1 replication is regulated by a dynamic set of interactions between viral and cellular RNA binding proteins and viral RNAs. In this application, we propose to identify new rules by which HIV-1 selectively packages its RNA genome and why it preferentially packages a dimeric genome. We will also define the interdependence of NC-gRNA interactions with other viral and host RNA-binding proteins that bind to the same gRNA at different phases of virus replication.

PI_NAMEs: KUTLUAY, SEBLA B. (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: 7SL RNA;Adenosine;Affect;Affinity;Anti-Retroviral Agents;Anti-viral Therapy;Avidity;Binding;Binding Proteins;Binding Sites;Biochemical;Cell membrane;Cells;Chimera organism;Complex;crosslinking and immunoprecipitation sequencing;Cytosol;Data;Defect;Defense Mechanisms;defined contribution;Dependence;Development;dimer;Dominant-Negative Mutation;empowerment;Equilibrium;Event;experimental study;gag Gene Products;Genetic;Genome;genomic RNA;Guanosine;HIV-1;Host Defense;imaging approach;In Vitro;Infiltration;insight;Integrase;Mediating;member;Messenger RNA;Modeling;Multiplexed Analysis of Projections by Sequencing;novel;Nucleocapsid;Nucleotides;particle;Phase;preference;Property;Protein Family;Proteins;recruit;RNA;RNA Binding;RNA Recognition Motif;RNA Splicing;RNA-Binding Proteins;RNA-targeting therapy;Site;Structural Protein;Testing;tool;trafficking;vector genome;Viral;viral genomics;viral RNA;Virion;virtual;Virus;virus host interaction;Virus Replication;Work;Zinc Fingers

PROJECT_TITLE: Selective packaging and protection of HIV-1 genomic RNAs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (02)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Gene expression is organized into diverse, droplet-like structures called transcriptional condensates in both the eukaryotic nucleus and the mitochondria. Here, in the context of biomolecular phase transitions, we will investigate how biomolecules–including the mitochondrial genome, its gene expression machinery and its RNA products–assemble and persist as disparate condensates within mitochondria. By studying the emergent structure-function relationships of mt- transcriptional condensates, we will determine the biophysical driving forces for the spatiotemporal organization of gene regulation in mitochondria and how anomalies contribute to mitochondrial (dys)function, with implications for human health.

PI_NAMEs: FERIC, MARINA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Behavior;Biology;Biophysical Process;Biophysics;Cell Nucleolus;Cell Nucleus;Cells;Complement;Cytoplasmic Granules;Disease;Disparate;DNA Polymerase II;driving force;experimental study;Functional disorder;Gene Expression;Gene Expression Regulation;Gene Structure;Genetic Transcription;Goals;Health;Higher Order Chromatin Structure;Human;improved;In Vitro;in vivo;light microscopy;Messenger RNA;Microscopy;Mitochondria;mitochondrial genome;Mitochondrial Matrix;Mitochondrial RNA;next generation sequencing;Phase;Phase Transition;Physical condensation;Physics;Polymers;Process;Production;programs;Proteins;Research;Ribosomal RNA;RNA;self organization;spatiotemporal;Stream;Structure;Structure-Activity Relationship;System;Theoretical model;Thermodynamics;ultra high resolution;Vision;Work

PROJECT_TITLE: Flow Of Gene Expression Across Mitochondrial Condensates


NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE This research proposal seeks to define how vaccination alters the course of gammaherpesvirus infection in immunocompetent mice, using the murine gammaherpesvirus 68 model system. While there is clear evidence that the immune system can limit gammaherpesvirus-induced infection, the stage at which infection is disrupted and the cell type(s) involved in protection remain poorly defined. By analyzing viral infection and immune parameters associated with control of gammaherpesvirus infection in the context of vaccination, these studies seek to address this gap in knowledge of gammaherpesvirus infection and disease in susceptible populations.

PI_NAMEs: CLAMBEY, ERIC T;VAN DYK, LINDA F. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Attenuated Vaccines;B-Lymphocytes;Biological Models;CD8-Positive T-Lymphocytes;cell type;Cells;cytokine;Disease;DNA Tumor Viruses;Frequencies;gammaherpesvirus;high dimensionality;Human;Human Herpesvirus 4;Human Herpesvirus 8;Immune;Immune system;Immunocompetent;Immunosuppression;In Vitro;in vivo;infected B cell;Infection;Integration Host Factors;Interferon Type II;Kaposi Sarcoma;Knowledge;latency-associated nuclear antigen;latent nuclear antigen;Lytic Phase;Malignant Neoplasms;Medical;Methods;mouse model;Mus;Myelogenous;Myeloid Cells;Non-Hodgkin's Lymphoma;Oncogenic Viruses;Outcome;Pathogenesis;Pathogenicity;Population;Predisposition;Primary Infection;Process;Regulation;Research Proposals;response;Risk;Role;single cell analysis;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Tropism;Vaccination;vaccination protocol;vaccine efficacy;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: Therapeutic targets in gammaherpesvirus infection


NIH_SPENDING_CATS: Clinical Research;Genetics;Infectious Diseases;Kidney Disease;Microbiome;Organ Transplantation;Prevention;Transplantation

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Infections are one of the leading causes of mortality in kidney transplant recipients who have weakened immune systems because of immunosuppressive therapy. Identifying kidney transplant patients at high risk for future infections could lead to interventions such as more intensive screening or decreasing immunosuppression. In this study, we plan to develop gut-based, blood-based, and urine-based microbial biomarkers for diagnosing and predicting infections in kidney transplant recipients.

PI_NAMEs: LEE, JOHN RICHARD (contact)

PROGRAM_OFFICER_NAME: ROBIEN, MARK ANDREW

PROJECT_TERMS: Anti-viral Therapy;Antibiotics;Bacteria;Bacterial Infections;Biochemical;Bioinformatics;Biological;Biological Assay;Biological Markers;Biomass;Blood;Blood Specimen Collection;cell free DNA;Clinical;Clinical Trials;Development;Diagnosis;diagnostic signature;DNA;End stage renal failure;Environmental Pollution;Escherichia;Escherichia coli;Feces;Future;Genetic Fingerprintings;Goals;Growth;gut bacteria;gut microbiome;gut microbiota;Health;high risk;high risk population;Human;Immune system;immunosuppressed;Immunosuppression;improved;Infection;Infection prevention;infection risk;Intervention;Kidney Transplantation;Klebsiella pneumoniae;Libraries;metabolomics;metagenomic sequencing;microbial;microbiome;Morbidity - disease rate;mortality;novel;Patients;Pilot Projects;Population;predictive test;Preparation;prevent;recruit;Regression Analysis;Risk;Risk Factors;risk prediction;Role;Sampling;screening;secondary analysis;Sensitivity and Specificity;Specimen;standard of care;Techniques;Therapeutic immunosuppression;Time;Tissues;Transplant Recipients;Transplantation;Urinary tract infection;Urine;virome;Virus Diseases;Volatile Fatty Acids;Work

PROJECT_TITLE: Microbial Biomarkers for Diagnosing and Predicting Infections in Kidney Transplant Recipients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative As an increasing number of older adults are suffering from Mild Cognitive Impairment (MCI), Alzheimer’s disease (AD) and AD-related dementias (ADRD); providing them with quality care in long term care (LTC) facilities is becoming problematic due to resource limitations, nursing shortage and high turnover among LTC nursing personnel. A novel approach to utilize socially assistive robotic systems that can meaningfully engage this group of older adults through physical, cognitive and social activities is proposed in the hope that such smart technology will be able to augment, and not replace, the current system of care. This study will contribute to the development of improved intelligent technology as an effective approach to engage older persons with dementia with the long- term goal of enhancing their function and quality of life as well as improving LTC staff satisfaction.

PI_NAMEs: MION, LORRAINE C;SARKAR, NILANJAN  (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: adaptive robot;Address;Administrative Supplement;age-related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;Architecture;assistive robot;Award;care systems;Caregivers;Caring;Clinical Trials;Cognitive;cognitive function;COVID-19 pandemic effects;Dementia;Development;Discipline of Nursing;effective intervention;Enrollment;Formal caregiver;Fostering;Future;Goals;Health care facility;Human Resources;Impaired cognition;improved;informal caregiver;Intervention;Long-Term Care;Long-Term Care Nursing;Mediating;meetings;Methods;mild cognitive impairment;mortality;multimodality;Nature;novel;novel strategies;Nursing Staff;older adult;Older Population;parent grant;Persons;pharmacologic;Phase;Physical Function;Prevalence;Quality of Care;Quality of life;recruit;Research;Resources;response;robotic system;satisfaction;Site;smart technologies;social;social assistive robot;Social Functioning;Social intelligence;Social isolation;Technology;Time;treatment as usual;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Impact of a Novel Socially Assistive Robotic Architecture on Engaging Older Adults with Mild Cognitive Impairment, Alzheimer's Disease, and Related Dementia in Long Term Care Settings

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Firearms Research;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Substance Misuse;Suicide;Suicide Prevention;Violence Research

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Most firearm deaths are suicides, and over half of suicides involve firearms. Further, nearly half of firearm suicide descendants were intoxicated at the time of death making alcohol use a key modifiable risk factor for reducing firearm suicide, which is essential to ameliorating the public health crises of suicide and firearm mortality and injury. We propose to integrate the study of suicide, problematic alcohol use, and firearm access into a coordinated line of research using survey data, qualitative methods, and ecological momentary assessment to advance our understanding of firearm suicide and identify key points for intervention to reduce its harms.

PI_NAMEs: HICKS, BRIAN M;ILGEN, MARK A. (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Address;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol measurement;alcohol use disorder;Alcoholic Intoxication;Alcohols;Area;Back;binge drinking;Blood alcohol level measurement;Cessation of life;Characteristics;Data;design;Ecological momentary assessment;Event;Exhibits;experience;Feeling suicidal;firearm access;Firearms;Focus Groups;General Population;Goals;Gun injury;gun violence;Guns;Heavy Drinking;help-seeking behavior;high risk;high risk population;Home;Injury;Intervention;Interview;Intoxication;Knowledge;Link;Location;Measures;Methods;modifiable risk;mortality;Ownership;Participant;Pathway interactions;Perception;Persons;Play;Population;Populations at Risk;Prevalence;Prevention approach;Probability Samples;Process;psychologic;Psychology;Public Health;public health priorities;Qualitative Methods;Qualitative Research;Recording of previous events;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;Role;Safety;Sampling;Series;Subgroup;suicidal;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;Survivors;Symptoms;Testing;Thinking;Time;timeline;trait;Violence;Work

PROJECT_TITLE: Determining the links between alcohol use, firearm access and suicide risk

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Kidney Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will study and engineer new principles of organ development toward building functional human tissue models. Once these new principles are applied, they will spur significant advances in tissue engineering for regenerative medicine. The proposed research is especially relevant to one of the NIH’s 2021-2025 strategic plan goals, which specifically highlights new cell engineering and bioengineering approaches to building human tissues for disease modeling that will contribute to reducing illness and disability.

PI_NAMEs: HUGHES, ALEX  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Address;Adult;Area;Autologous;Biomedical Engineering;Bioreactors;Body System;Cell Communication;cell type;Cells;cellular engineering;Chronic Kidney Failure;Complex;Data;Development;Dialysis procedure;disability;disease model;Donor person;Duct (organ) structure;Economic Burden;End stage renal failure;Endowment;Engineering;Fetal Kidney;Fibroblast Growth Factor;Filtration;Future;Generations;Goals;Histocompatibility;Human;human induced pluripotent stem cells;human stem cells;human tissue;Hypertension;Immunocompromised Host;improved;in vivo;induced pluripotent stem cell;innovation;Kidney;Knowledge;Lung;Mammary gland;Maps;Metanephric Diverticulum;Molecular;molecular clock;Morbidity - disease rate;Morphogenesis;Mus;neonate;nephrogenesis;nephron progenitor;Nephrons;novel;novel strategies;optogenetics;Organ;organ growth;Organ Transplantation;Organoids;Outcome;Pacemakers;Patients;Pattern;Periodicals;Periodicity;Phase;Plumbing;Population;Production;programs;Prostate;Protocols documentation;Public Health;Quality of life;Reaction;reconstitution;Regenerative Medicine;regenerative tissue;Renal Replacement Therapy;Renal Tissue;replacement tissue;Research;Risk Factors;scale up;segregation;Signal Pathway;Signal Transduction;Somites;spatiotemporal;stem cell differentiation;stem cell division;stem cell organoids;stem cell population;stem cells;Strategic Planning;Structure;Technology;temporal measurement;Time;Tissue Engineering;Tissue Model;Tissues;transcriptome sequencing;Transplantation;Trees;Tretinoin;United States National Institutes of Health;urinary;Vesicle;WNT Signaling Pathway;Work

PROJECT_TITLE: Rhythmic pace-making of nephron induction for renal replacement tissues

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This program centers on developing new organometallic catalysts that can selectively activate different groups on organic molecules according to the wavelength of light irradiation. This will allow for the iterative synthesis of biological targets in one-pot, facilitating rapid access to chemical libraries for medicinal screening and the optimization of biological function. The new technologies developed in the formation of carbon-carbon bonds will also be amenable to automated synthesis platforms of use in medicinal chemistry laboratories.

PI_NAMEs: SANDFORD, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Switchable Organometallic Catalysts for Organic Reaction Development

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]