NIH_SPENDING_CATS: Aging;Aphasia;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Rehabilitation;Stroke

ORG_CITY: MILWAUKEE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE This project will develop a model to decode electrical brain activity while people think of concepts into their concept identities. A model such as this could be used to develop a neuroprosthetic device to assist with speech for people that have severe speech deficits such as aphasia following stroke.

PI_NAMEs: GROSS, WILLIAM L. (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acute;Aphasia;Area;Articulation;awake;Brain;brain based;brain computer interface;brain electrical activity;Brain Neoplasms;brain surgery;Characteristics;Chronic;Clinical;Clinical Trials;Code;cohort;Communication;Computer Models;Data;deep neural network;density;design;Development;Devices;Disabling;Electrocorticogram;Electrophysiology (science);Eligibility Determination;experimental study;Foundations;Functional Magnetic Resonance Imaging;Future;Goals;Image;Imaging technology;Impairment;Implant;Individual;innovation;Institution;Knowledge;Language;Language Disorders;Left;Lesion;Location;Machine Learning;machine learning model;Magnetoencephalography;Maps;Methods;Modality;model development;Modeling;Motor;neural;Neural Network Simulation;neuroprosthesis;Non-aphasic;novel;operation;Operative Surgical Procedures;Outcome;Patient Care;Patients;Pattern;Performance;Persons;Phase;phonology;Population;portability;post stroke;preservation;Production;Psyche structure;Recovery;Research;Retrieval;Semantic memory;Semantics;Signal Transduction;Solid;Specific qualifier value;Specificity;Speech;Stroke;stroke outcome;stroke-induced aphasia;System;Technology;temporal measurement;Testing;Training;Translating

PROJECT_TITLE: Decoding mental concept identities using electrocorticography

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hypertension;Kidney Disease

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Blood pressure is an important, modifiable risk factor for poor clinical outcomes in hemodialysis patients and yet the optimal treatment of blood pressure remains poorly understood in this population. Our hypothesis is that outcomes will improve in hemodialysis patients if physicians measure and treat home blood pressure, rather than blood pressure measured at the time of dialysis, which is the current practice and what guidelines recommend. We propose a 2-center cross-over randomized controlled trial (N = 200) to test whether targeting a home vs. pre-dialysis systolic blood pressure <140 mmHg will reduce rates of intradialytic hypotension, an important clinical outcome.

PI_NAMEs: BANSAL, NISHA  (contact);HSU, CHI-YUAN

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;adverse outcome;Algorithms;Attitude;Belief;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure medication;Cardiovascular Diseases;cardiovascular risk factor;Cessation of life;Clinical;clinical care;Clinical Trials;Cross-Over Studies;Data;design;Dialysis procedure;Dryness;Event;Fatigue;feasibility testing;follow-up;Foundations;Goals;Guidelines;Health Technology;Hemodialysis;Heterogeneity;high risk;Home;Hypotension;implementation science;improved;Knowledge;Literature;Maintenance;Measurement;Measures;mHealth;Modernization;modifiable risk;mortality;mortality risk;Multicenter Trials;Muscle Cramp;optimal treatments;Outcome;Participant;Patients;Perception;Phase;Physicians;Pilot Projects;pilot trial;Population;post intervention;primary outcome;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Design;Risk Factors;Schedule;secondary outcome;Shapes;Standardization;Surveys;Technology;Testing;Text Messaging;Time;Titrations;transmission process;treatment arm;treatment effect;treatment strategy;Weight;willingness

PROJECT_TITLE: Home Blood Pressure in Hemodialysis (HOME-BP)

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases

ORG_DEPT: DENTISTRY

PHR: Several virulence factors have been proposed to contribute to the ability of Porphyromonas gingivalis, a dental pathogen closely associated with periodontitis, to colonize and thrive in diseased sites. In this application the ability by which P. gingivalis lipid A, an essential component of the cell wall and prime contributor to immune evasion, modulates its structure will be characterized. We have identified three key P. gingivalis lipid A modifying genes and we will determine how they are regulated, play a role in virulence factor production, and how their expression correlates to health and disease clinical status.

PI_NAMEs: JAIN, SUMITA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Animal Model;Cell Wall;Cellular Structures;Characteristics;Chronic;Clinical;Data;Dental;Dental Plaque;diagnostic development;diagnostic tool;Disease;dysbiosis;Environmental Risk Factor;Enzymes;Excision;Exhibits;fitness;Future;Gene Expression;Gene Modified;Genes;gingipain;Gingivitis;Glucosamine;Gram-Negative Bacteria;Growth;Health;Human;Immune Evasion;immunoregulation;In Vitro;in vivo;Infection;Infection Control;Inflammation;Inflammatory;Innate Immune Response;inorganic phosphate;Knowledge;Link;Lipid A;Longitudinal Studies;Mediating;Membrane;microbial;Modification;Molecular;mutant;Natural Immunity;novel;pathogen;Pathogenesis;Peptide Hydrolases;Periodontal Diseases;Periodontitis;Phenotype;Phosphoric Monoester Hydrolases;Porphyromonas gingivalis;Positioning Attribute;Prevalence;Process;Production;Property;Proteins;receptor;Regulation;Regulator Genes;Reporting;response;Role;Sampling;Site;Structure;System;Testing;Therapeutic;TLR4 gene;tool;Transcription Initiation Site;Variant;Vertebral column;Vesicle;Virulence;Virulence Factors;Work

PROJECT_TITLE: Regulation and impact of lipid A modification in the pathogenesis of Porphyromonas gingivalis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: COLLEGE STATION

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative  There is a need to develop an effective therapeutic strategy that prevents or alleviates age-related cognitive dysfunction. Using a mouse model of aging, this proposal focuses on testing the efficacy of a non-invasive, intranasal administration of extracellular vesicles generated from human induced pluripotent stem cell-derived neural stem cells for maintaining better cognitive and memory function in old age. If successful, the approach would provide the benchmark for the clinical translation of extracellular vesicle therapy to combat age-related dementia in the future.

PI_NAMEs: SHETTY, ASHOK K (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Adenosine Monophosphate;Age Months;age related;age related changes;Age-associated memory impairment;Aging;aging brain;Allogenic;Anti-Inflammatory Agents;Autophagocytosis;behavior test;Benchmarking;Brain;Brain region;brain tissue;cell type;Cells;clinical translation;Cognitive;cognitive function;combat;CSF1R gene;Data;Dementia;Diet;Dose;Effectiveness;effectiveness evaluation;efficacy testing;Ensure;extracellular vesicles;Family;Female;FRAP1 gene;functional improvement;Future;Gene Expression;Goals;Hippocampus;Homeostasis;human induced pluripotent stem cells;human old age (65+);Impaired cognition;improved;Inflammasome;inhibitor;Intervention;Intranasal Administration;male;marenostrin;Measures;Medial;Mediating;Membrane;Memory;Memory impairment;Microglia;MicroRNAs;middle age;Mitochondria;mouse model;Mus;nerve stem cell;neurobehavioral test;neurogenesis;neuroinflammation;Neurons;neuroprotection;novel strategies;Nucleic Acids;old mice;Outcome;Pathway interactions;Phenotype;Prefrontal Cortex;prevent;Property;Protein Kinase;Proteins;Proteomics;Regimen;Research;Rodent Model;Role;Signal Pathway;Signal Transduction;Synapses;Testing;Therapeutic;therapeutically effective;Time;transcriptome sequencing;uptake;virtual

PROJECT_TITLE: Neural Stem Cell-derived EVs for Improving Aged Brain Function

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE The strongest genetic risk factor for developing late-onset Alzheimer’s disease is carrying the E4 allele of APOE, which codes for the protein apoliprotein E (APOE). We are testing the function of APOE in the fat metabolism of brain cells called astrocytes and microglia. These studies will lead to increased understanding of the mechanism by which APOE4 causes increased risk of neurodegeneration and could lead to the identification of new drug targets.

PI_NAMEs: COHEN, SARAH  (contact);JOHNSON, LANCE ALLEN

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Affect;Age;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloidosis;Apolipoprotein E;apolipoprotein E-4;Area;Astrocytes;Brain;brain cell;Brain region;Cause of Death;Cell Death;cell type;Cellular biology;Central Nervous System;Code;Communities;cytokine;Cytoplasm;Data;Data Set;Databases;Dementia;Dependence;Deposition;disability;Drug Targeting;Educational workshop;Effector Cell;Endoplasmic Reticulum;Fluorescence-Activated Cell Sorting;Future;genetic risk factor;Genotype;Glycolysis;Homeostasis;human old age (65+);Image;Immune;in vivo;Inflammation;Inflammatory;insight;Investigation;Knockout Mice;Knowledge;laboratory experience;Late Onset Alzheimer Disease;lipid metabolism;Lipid Peroxidation;lipid transport;Lipids;Lipoproteins;Metabolism;Microglia;Microscopy;Molecular;mouse model;Mus;Natural Immunity;Nerve Degeneration;Nervous System;Neuroglia;Neurons;new therapeutic target;normal aging;novel;Older Population;particle;Pathway interactions;Play;prevent;Protein Isoforms;Proteins;Research;Resources;Risk;Role;Surface;Testing;Therapeutic;trafficking;United States;Visualization;Work

PROJECT_TITLE: Assessing the role of APOE in glial lipid droplet metabolism and function


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Characterizing mechanisms that create and sustain racial disparities in Alzheimer's disease and related dementias (ADRD) is of critical importance to the diverse, aging population of the U.S. The proposed project will fill an important void in examining the extent to which neighborhood resources contribute to disparities in brain and cognitive aging, as well as whether social networks can buffer against neighborhood disadvantage. Results could have implications for interventions targeted at multiple levels to prevent or delay age-related cognitive decline and reduce racial disparities in ADRD.

PI_NAMEs: SOL, KETLYNE  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Affect;Age;Age-associated memory impairment;Aging;aging brain;aging population;Alzheimer's disease related dementia;American;Area;Attenuated;Biological;Black American;Black Populations;Black race;black/white disparity;Brain;brain dysfunction;Buffers;built environment;caucasian American;Characteristics;Child;clinical care;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive reserve;Cohort Studies;County;Data;data archive;Data Collection;Data Pooling;Data Set;dementia risk;density;Development;Disparity;Education;Environment;ethnic minority;Exposure to;Family;Friends;Goals;Grain;Grant;Health;health disparity;Health Promotion;human old age (65+);improved;Income;Individual;Individual Differences;individual variation;Inequity;Intervention;Knowledge;Libraries;Magnetic Resonance Imaging;Measures;Mediating;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;metropolitan;Michigan;Modeling;neighborhood disadvantage;Neighborhoods;Neuroanatomy;neuroimaging;Not Hispanic or Latino;older adult;Participant;Physical activity;prevent;protective effect;Psychology;Race;racial difference;racial disparity;racial minority;Recreation;recruit;Research;residential segregation;resilience;Resolution;Resources;Risk;Role;Sampling;Scientist;segregation;Siblings;skills;social;social factors;Social Interaction;Social Network;Sorting;Spouses;stress management;Time;Training;Universities;Writing

PROJECT_TITLE: Risk and resilience mechanisms underlying race disparities in ADRD: An examination of neighborhood resources, social networks, brain integrity, and cognition

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Immunotherapy;Neurosciences;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The formation of new nerve populations within and around solid tumors plays an active role in cancer development, progression, and treatment resistance. In the proposed study, we will identify the exact neuronal mechanisms that support tumor progression by enabling oral cancer cells to evade immune surveillance. This new knowledge will position us to develop impactful, rational treatment approaches to address the neural signaling responsible for the suppressive modulation of immune system and reestablish healthy equilibrium of oral tissues.

PI_NAMEs: AMIT, MORAN  (contact);CALIN, GEORGE A.

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Ablation;Address;Adrenergic Agents;Afferent Neurons;Axon;Biological Models;Biometry;Breast;calin;Cancer Biology;cancer cell;cancer genetics;Cancer Patient;cancer therapy;candidate identification;Cell Physiology;cell type;Cells;Cellular biology;Cellular Structures;Clinical;Communication;Complex;Cues;Cytotoxic T-Lymphocytes;Data;Development;Environment;Epithelium;Equilibrium;Event;extracellular vesicles;functional genomics;functional plasticity;Genes;genetic approach;Genetically Engineered Mouse;Genomic approach;Goals;Growth;Head and Neck Squamous Cell Carcinoma;Homeostasis;Human;Imaging Techniques;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune Evasion;Immune response;Immune signaling;Immune system;Immunologic Surveillance;Immunology;immunoregulation;Immunosuppression;Immunotherapy;improved;in vitro activity;Induced Neurons;Infiltration;Inflammatory Response;innovation;insight;Knowledge;malignant mouth neoplasm;Malignant Neoplasms;Mediating;MicroRNAs;Molecular;molecular imaging;mouse model;mouth squamous cell carcinoma;neoplastic cell;Nerve;Nerve Fibers;nerve supply;Nervous System;neural;Neurobiology;Neuroepithelial, Perineurial, and Schwann Cell Neoplasm;Neuroimmune;neuromechanism;neuron loss;Neurons;neuroregulation;neurotransmission;neurotransmitter release;new therapeutic target;novel therapeutic intervention;Oncology;Operative Surgical Procedures;Oral;oral cavity epithelium;oral tissue;Outcome;Pancreas;paracrine;Pathology;Patients;PD-1 blockade;Peripheral Nervous System;Persons;pharmacologic;Play;Population;Positioning Attribute;Pre-Clinical Model;prevent;programs;Prostate;Proteins;Quality of life;recruit;Research;Research Personnel;Resistance;response;RNA;Role;Signal Induction;Signal Transduction;Solid Neoplasm;Stomach;success;T-Lymphocyte;targeted cancer therapy;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Time;Tissues;Transcript;Transcriptional Activation;transcriptomics;treatment response;treatment strategy;tumor;Tumor Biology;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Subtype;Tumor-Derived;tumor-immune system interactions;tumorigenesis;tumorigenic;Work

PROJECT_TITLE: Harnessing the nervous system to overcome resistance to immunotherapy in oral cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Neurosciences;Opioids;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative A common effect of alcohol and many other drugs of abuse is the disruption of presynaptic long-term synaptic depression in striatal neurocircuits and restoring this lost plasticity may be therapeutic for treating alcohol and substance use disorder and/or pathological sequelae associated with long-term drug abuse. Here we develop an innovative technique to decipher components of the presynaptic interactome that are engaged during the induction of striatal synaptic plasticity at distinct striatal synapses (corticostriatal versus thalamostriatal) that display different forms of plasticity and have differential responses to in vivo alcohol exposure as well as determine how alcohol affects those presynaptic interactomes. In using this novel approach, we hope to identify previously unknown signaling proteins that may be promising therapeutic targets for pharmacological intervention in alcohol use disorder and addiction.

PI_NAMEs: ATWOOD, BRADY ;BAUCUM, ANTHONY J. (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Ablation;addiction;Address;adeno-associated viral vector;Adult;Affect;alcohol abuse therapy;alcohol behavior;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;Animals;Anterior;Behavior;Biochemical;Biotin;Biotinylation;Black Box;Brain;Brain region;Cell Culture Techniques;Cell Physiology;cognitive control;Compulsive Behavior;Corpus striatum structure;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Development;differential expression;Disease;disease model;Dorsal;dorsal proteins;Drug abuse;Drug Addiction;Drug Modelings;drug of abuse;Electrophysiology (science);Ethanol;experimental study;Female;Future;Genetic;genetic manipulation;Glutamates;Goals;habit learning;in vivo;Infusion procedures;Injections;innovation;insight;Intervention;Knowledge;Label;Ligase;Long-Term Depression;male;Mass Spectrum Analysis;Mediating;Mental Depression;Methodology;Methods;Modeling;Molecular;Molecular Target;mu opioid receptors;Mus;Naltrexone;neurophysiology;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Pathologic;Pharmaceutical Preparations;pharmacologic;Pharmacology Study;Physiological;Post-Translational Protein Processing;Predisposition;presynaptic;Presynaptic Terminals;protein expression;protein protein interaction;Proteins;Proteome;Proteomics;receptor;Receptor Signaling;Research Personnel;Resistance;response;restoration;Saline;Signal Pathway;Signal Transduction;Signaling Protein;Slice;socioeconomics;Streptavidin;Substance Use Disorder;symptom management;Synapses;synaptic depression;Synaptic plasticity;Synaptic Potentials;Techniques;Testing;Thalamic structure;Therapeutic;therapeutic target;Tissues;tool;Translations;vesicular release;Viral Vector;Work

PROJECT_TITLE: A novel proteomics approach to identify alcohol-induced changes in synapse-specific presynaptic protein interactions.

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Activity;Physical Rehabilitation;Rehabilitation;Stroke

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

PHR: Project Narrative The goal of lower limb rehabilitation after stroke is restoration of independent walking at home and in the community. Few stroke survivors achieve this goal. This project proposes a Stage 1 rehabilitation trial to examine the safety, acceptability, tolerance, therapeutic effects of a novel exercise intervention designed to overcome barriers to recovery and improve walking after stroke.

PI_NAMEs: SCHINDLER-IVENS, SHEILA M (contact)

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: Address;Adoption;Adverse event;Bilateral;Clinical;Communities;Coupled;Data;design;Development;Dose;effective intervention;effective therapy;Exercise;exercise intervention;Exercise Therapy;Funding Opportunities;Future;gait rehabilitation;Goals;Home;improved;Intervention;Laboratories;Left;limb movement;Limb structure;Lower Extremity;Measures;Mechanics;Modeling;Motor;motor impairment;motor recovery;Movement;Muscle;Nature;novel;novel therapeutics;Outcome;Output;Paresis;Participant;patient tolerability;Performance;Phase;Physiological;post stroke;Protocols documentation;Randomized, Controlled Trials;Recovery;Rehabilitation therapy;Research;response;restoration;Rewards;Risk;Robotics;Running;Safety;Specific qualifier value;standard care;Stroke;stroke rehabilitation;stroke survivor;Target Populations;Technology;Testing;Therapeutic Effect;therapy design;Training;treatment response;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: CUped: An Approach to Motor Recovery Post-Stroke, not Compensation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE

ORG_ZIPCODE: SW7 2AZ

PHR: Next-generation influenza vaccines need to induce long-lived heterosubtypic immunity, particularly in the upper respiratory site of initial infection. Existing technologies are insufficient for profiling mucosal humoral immunity at the functional level required for testing future vaccines. To resolve this limitation, this proposal aims to partner highly standardised sampling of the upper airway by nasosorption with flexible, scalable, sensitive assays for neutralisation and Fc- dependent antibody function.

PI_NAMEs: THWAITES, RYAN  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Address;Adoption;Antibodies;antibody-dependent cell cytotoxicity;Antigens;arm;Attenuated;Binding;biobank;Biological Assay;Cohort Studies;Data;Development;dimer;efficacy study;flexibility;Future;Homo;Human;Humoral Immunities;Immune response;Immunity;Immunoassay;Immunoglobulins;Immunologic Memory;Immunology;Infection;Infection prevention;Influenza;Influenza A Virus, H1N1 Subtype;Influenza vaccination;influenza virus vaccine;Measurement;Mediator;Methods;minimally invasive;Mucosal Immunity;mucosal site;Mucous Membrane;next generation;Nose;Outcome;peripheral blood;Positioning Attribute;prevent;Proteins;Protocols documentation;Qualifying;Reference Standards;Reproducibility;Research;respiratory;Respiratory Mucosa;respiratory virus;response;Sampling;Sampling Studies;Signal Transduction;Site;Specificity;Standardization;T-Lymphocyte;Techniques;Technology;Testing;tool;Upper respiratory tract;Vaccination;vaccine efficacy;Vaccines;Virus;Virus Diseases;volunteer

PROJECT_TITLE: Immunity in the Nose to inFLUENza: Correlates of Efficacy (INFLUENCE)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Substance Misuse

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

ORG_STATE: MA

PHR: PROJECT NARRATIVE This research has two key objectives to improve HIV prevention for MSM, (1) to develop a better understanding of how alcohol influences sexual decision-making in their day-to-day lives, and (2) to reduce sexual risk in contexts characterized by intoxication and arousal through a behavioral intervention.

PI_NAMEs: MAISTO, STEPHEN A;PALFAI, TIBOR P. (contact);SIMONS, JEFFREY S

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adult;Affect;AIDS prevention;Alcohol consumption;alcohol effect;Alcoholic Intoxication;Alcohols;Arousal;Basic Behavioral Science;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Mechanisms;binge drinking;brief intervention;Cognitive;cognitive capacity;cognitive testing;condomless anal sex;condoms;Counseling;Cues;Data;Decision Making;design;Desire for food;Development;discounting;Effectiveness;effectiveness testing;Environment;executive function;Exhibits;experience;experimental study;follow-up;Fostering;Goals;group intervention;Heavy Drinking;HIV;HIV diagnosis;Human immunodeficiency virus test;improved;Incidence;Informal Social Control;insight;Intervention;intervention effect;Intoxication;laboratory experiment;Laboratory Finding;Laboratory Research;Link;longitudinal design;male;Measures;Mediating;Mediator;men who have sex with men;Methods;modifiable risk;Motivation;motivational enhancement therapy;Pattern;Persons;post intervention;Prevention;Prevention approach;preventive intervention;Process;psychologic;Public Health;Randomized;Research;response;Rewards;Risk;Risk Factors;Risk Reduction;Role;Route;Sampling;Self-control as a personality trait;Sex Behavior;Sexual Arousal;sexual risk reduction;sexual role;Short-Term Memory;Testing;Text Messaging;theories;therapy design;Translating;transmission process;Treatment Efficacy;United States;Work

PROJECT_TITLE: Alcohol and "Heat of the Moment" Sexual Decision Making among MSM: Identifying Mechanisms of Sexual Risk and Promoting Behavior Change Through Brief Intervention


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Infectious Diseases;Pediatric;Precision Medicine;Sepsis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Establishment of a multi-center biobank of patient-specific pluripotent stem cells for pediatric sepsis research. PROJECT NARRATIVE:  Children with sepsis—a life threatening condition due to an abnormal patient response to an infection— represent a mixed group with varying underlying biology. Our inability to easily study differences in patient- specific biology at the cellular level has prevented the development of the right drugs for the right patients. To address this problem, we seek to establish a vast collection of induced pluripotent stem cells from children with sepsis, which can be used to better understand disease mechanisms and improve patient health outcomes.

PI_NAMEs: ATREYA, MIHIR R (contact);LAUTZ, ANDREW JOHN;ZINGARELLI, BASILIA

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acceleration;Acute;Address;advanced disease;age related;Antibiotics;Benchmarking;biobank;Bioinformatics;biological heterogeneity;Biological Markers;Biology;Body System;Caring;CD34 gene;Cell Line;Cell Therapy;cell type;Cells;Child;Clinical Data;Clinical Trials;Collecting Cell;Collection;Communities;Complex;Core Facility;Coupled;Critically ill children;Cryopreservation;Databases;Dedications;Development;differentiation protocol;Disease;disease model;disease phenotype;Drug Screening;Endothelial Cells;Enrollment;epigenomics;experience;experimental study;Exposure to;Faculty;Failure;Funding;gene environment interaction;Generations;genome editing;Goals;Health;Heterogeneity;Human;human induced pluripotent stem cells;Immune response;improved;improved outcome;in vitro Model;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Infection;Infrastructure;Institution;Leadership;Leukocytes;Life;Malignant Neoplasms;Modeling;Molecular Target;monocyte;mortality risk;multiple omics;National Institute of General Medical Sciences;next generation;novel;Organ;Organoids;Outcome;participant enrollment;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patient Recruitments;patient response;Patients;Pediatric cohort;pediatric patients;pediatric sepsis;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase;Phased Innovation Awards;Phenotype;pluripotency;Pluripotent Stem Cells;precision medicine;Precision therapeutics;prevent;Process;Protocols documentation;PTPRC gene;Research;Research Personnel;response;Risk;risk stratification;RNA;Role;Sampling;scale up;Scientific Advances and Accomplishments;Scientific Inquiry;Sepsis;septic;Septic Shock;Serum;single cell genomics;Source;Standardization;Therapeutic;transcriptomics;Whole Blood;XCL1 gene

PROJECT_TITLE: Establishment of a multi-center biobank of patient-specific induced pluripotent stem cells for pediatric sepsis research

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases;Substance Misuse

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: CATHOLIC UNIVERSITY OF AMERICA

ORG_STATE: DC

PHR: NARRATIVE Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world with over 600,000 new cases per year and a dismal five-year survival rate at less than 9%. Most HCC patients have chronic liver disease resulting mainly from HCV/HBV infection, chronic alcohol consumption or aflatoxin exposure. Although most patients that develop HCC have cirrhosis or hepatitis, the mechanisms promoting HCC differ between pathologies such that not all cases, in principle, should be treated the same. Thus, it is important to understand the mechanisms that promote HCC due to chronic ethanol exposure, a form of HCC that is on the rise as HCV and HBV infections are being better prevented and treated.

PI_NAMEs: TUMA, PAMELA L. (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: 8q24;Affect;Aflatoxins;Alcohol consumption;alcohol exposure;Alcohols;Animal Model;Automobile Driving;Benign;Biochemical;c-myc Genes;Cell Line;Cells;Cellular biology;Cholangiocarcinoma;Chromosomes;Chronic;chronic alcohol ingestion;chronic liver disease;Cirrhosis;clinically relevant;cohort;Combined Modality Therapy;Coupled;Cultured Cells;diagnostic biomarker;Drug resistance;drug sensitivity;epithelial to mesenchymal transition;Epithelium;Etiology;Excision;experimental study;Exposure to;Fluorescent in Situ Hybridization;gene repression;Genomic Instability;Goals;Hepatitis;Hepatitis B Infection;Hepatitis C;Hepatitis C virus;Hepatocyte;Human;human tissue;imaging facilities;In Vitro;knock-down;Label;lymph nodes;Malignant Epithelial Cell;Malignant neoplasm of liver;Malignant Neoplasms;medical schools;member;Mesenchymal;Monitor;Morphology;Neoplasm Metastasis;Normal Cell;novel therapeutics;overexpression;Paraffin Embedding;Pathology;patient response;patient subsets;Patients;Pattern;Phenotype;prevent;Primary carcinoma of the liver cells;Primary Neoplasm;Prognosis;prognostic;protein expression;Renal Cell Carcinoma;Repression;Resources;Services;Site;Stains;stemness;Survival Rate;Testing;Tissue Sample;Tissues;trait;transcriptome;translational impact;translational study;treatment response;treatment strategy

PROJECT_TITLE: Mechanisms that promote hepatocellular carcinoma due to chronic ethanol exposure

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Colorectal cancer is the second leading cause of cancer death in the United States and disparities in mortality by race and ethnicity persist. This application seeks to elucidate why colorectal cancer disparities may persist even when similar rates of screening have been achieved by comprehensively evaluating the entire screening continuum from the tests used and screening quality to follow-up care and guideline-concordant treatment in a dynamic cohort of about 3.8 million people per year over the 2003-2019 17-year period. We will perform mixed- methods studies among people 45-85 years old in Kaiser Permanente in both Northern and Southern California and model the extent to which differences along the screening process cumulatively contribute to disparities.

PI_NAMEs: CORLEY, DOUGLAS ALLEN;DOUBENI, CHYKE ABADAMA (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Address;adenoma;Age;Attention;attributable mortality;Black American;Black Populations;Black race;California;Cancer Etiology;cancer health disparity;Cause of Death;Cessation of life;Characteristics;Clinical Practice Guideline;cohort;Collaborations;Colon;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Communities;Data;Data Element;Death Rate;Detection;Diagnosis;Diagnostic;Disadvantaged;Disease Outcome;Disparity;disparity elimination;Early Diagnosis;Education;ethnic disparity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;experience;follow-up;Foundations;Goals;Guidelines;Health;health equity;human very old age (85+);implementation evaluation;implementation strategy;Improve Access;Incidence;Indigenous;Information Systems;innovation;Intervention;Interview;Intestines;Location;Longitudinal trends;Malignant Neoplasms;Medicare/Medicaid;member;men;Methods;Modeling;models and simulation;mortality;mortality disparity;multidisciplinary;Native American population;older men;older women;Operative Surgical Procedures;Outcome;Patients;Pattern;Persons;Phase;Population;Positioning Attribute;Preparation;Prevention;Process;Productivity;public health priorities;Race;racial disparity;racial minority;racial minority population;racial population;Reporting;Research;screening;screening program;Screening Result;SEER Program;sex as a biological variable;social;social disparities;social factors;social group;sociodemographics;Standardization;success;Survival Rate;Testing;therapy design;Treatment outcome;United States;United States Preventative Services Task Force;Variant;Woman;Work

PROJECT_TITLE: Addressing Disparities in Outcomes of Screening for Colorectal Cancer in Community-Based Settings

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative There are still no effective drugs to treat Alzheimer’s disease (AD). However, there are resilient people who have evidence of disease pathology without displaying cognitive decline. Non- coding RNAs (ncRNAs) are powerful regulators of coding and non-coding gene expression, critical for maintaining homeostasis, resisting cellular stresses, and preventing disease processes. Here we systematically identify ncRNAs that regulates the resilience in AD using comparative transcriptomic analysis, explore the regulatory mechanisms these ncRNAs in neural cells, and validate their protective roles using advanced three-dimensional human neural cell culture models of AD. If successful, future trials on safe-to-use non-coding RNAs could be performed to protect humans against Alzheimer’s disease.

PI_NAMEs: HIDE, WINSTON ALEXANDER;KIM, DOO YEON ;SLACK, FRANK J. (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Address;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid beta-Protein;Basic Science;Biological;biological adaptation to stress;Biological Models;Biology;Brain;Brain region;brain tissue;Cell Culture Techniques;cell dimension;Cell Line;Cell model;Cell Physiology;Cell Survival;Cells;Cellular Stress;Code;Cognition;Cognitive;comparative;Compensation;Complex;CRISPR interference;Data;Dementia;Disease;Elderly;exosome;Future;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic Transcription;Goals;Health;Homeostasis;Human;human induced pluripotent stem cells;human subject;Impaired cognition;in silico;In Situ;In Vitro;Individual;Intervention;knock-down;Life;Link;loss of function;Mediating;MicroRNAs;Modeling;Molecular;nanoparticle;Neurites;Neurofibrillary Tangles;Neuroglia;neuroinflammation;Neurons;neuropathology;neuroprotection;novel;Organoids;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;prevent;Process;promote resilience;rare variant;Regulation;Regulator Genes;resilience;resilience factor;response;RNA;Role;Serum;small hairpin RNA;Solid;Systems Biology;Technology;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Tissues;tool;transcriptomics;Translational Research;Tropism;Untranslated RNA

PROJECT_TITLE: Non-coding RNAs in resilience to Alzheimer’s Disease


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Brain Disorders;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Heart Disease;Heart Disease - Coronary Heart Disease;Intellectual and Developmental Disabilities (IDD);Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Substance Misuse

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The long-term goal of this research is to decipher cardiovascular health outcomes in adults with FASD and to identify novel molecular mechanisms and biomarkers for ethanol-induced congenital heart defects and subsequent cardiac dysfunction in adulthood. We propose to accomplish these goals through a retrospective study on adult patients with and without FASD and by evaluation of a zebrafish model of embryonic alcohol exposure. Our findings will enable early identification or intervention in at-risk patients with FASD and expand our mechanistic understanding of the lasting effects of prenatal alcohol exposure on the heart.

PI_NAMEs: BURNS, C. GEOFFREY ;BURNS, CAROLINE E (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: Adult;Affect;Animal Model;Biological Markers;biomarker identification;Blood specimen;Body mass index;Cardiac;Cardiac Myocytes;cardiometabolism;Cardiomyopathies;Cardiovascular Abnormalities;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cessation of life;Cholesterol;Clinic;clinically relevant;cohort;Cone;Congenital Heart Defects;conotruncal heart defect;cytokine;Data;Defect;Diagnosis;Diet;disease model;Disease Outcome;Disease susceptibility;Double Outlet Right Ventricle;Doxorubicin;Dyslipidemias;Early identification;Early Intervention;Echocardiography;EFRAC;Embolism;Embryo;embryonic alcohol exposure;Embryonic Heart;Embryonic Induction;Ethanol;Evaluation;exercise capacity;Fatty acid glycerol esters;Female;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Future;Goals;Health;Heart;Heart Abnormalities;heart defect;Heart failure;heart function;High Density Lipoproteins;Human;Hypertension;Immune;Incidence;Inflammation;Inflammatory;insight;Larva;life span;Low-Density Lipoproteins;male;Mediating;Mediator;Metabolic;migration;Modeling;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;Myocardial;Myocardial dysfunction;Myocardial Infarction;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Outcome;Overweight;Pathology;Pathway interactions;patient population;Patient-Focused Outcomes;Patients;Phenotype;Plasma;Platelet-Derived Growth Factor;predictive marker;Predisposition;premature;Prevalence;Reporting;Research;Retrospective Studies;Risk;Risk Factors;Role;septal defect;Severities;Stress cardiomyopathy;Stroke;Structure;Testing;Tetralogy of Fallot;transcriptome sequencing;Triglycerides;Ukraine;Validation;vascular injury;Ventricular;women patients;Work;Zebrafish

PROJECT_TITLE: Cardiovascular disease in fetal alcohol spectrum disorder


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Mental Health

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Project Narrative By 2030, nearly 20% of the US population is expected to be 65 years of age or older, and by 2050, 88.5 million US citizens are projected to be over 64 years old. Given the rate at which the national population is aging, it is important to understand how cognitive and emotional processes change across the lifespan and identify processes associated with healthy aging. Such information can inform interventions to promote emotional well-being and subsequent mental and physical health in older adults, as well as people of all ages.

PI_NAMEs: SHOOK, NATALIE  (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adult;Affect;Affective;Age;age difference;Aging;Assessment tool;Attention;Awareness;Behavior;Behavior assessment;Behavioral;Cessation of life;Code;Cognitive;cognitive process;Collaborations;Colorado;Crying;Data Reporting;Devices;digital;Emotional;Environment;Event;Exhibits;experience;Feasibility Studies;Foundations;Future;Goals;Happiness;Health;healthy aging;Hour;human old age (65+);indexing;Individual;information processing;innovation;Intervention;Knowledge;Language;Laughter;Life;life span;Literature;loved ones;Measures;member;Mental Health;Methodology;middle age;Moods;novel;older adult;Participant;Patient Self-Report;Personal Satisfaction;Persons;physical conditioning;Population;positive mood;Process;programs;psychologic;recruit;Reporting;Research;Role;Sampling;social;Social Behavior;Social Environment;stem;Systems Analysis;Testing;theories;Time;tool;Verbal Behavior;Weight;Well in self;young adult

PROJECT_TITLE: Decoding Age Differences in Emotional Well-being and Positivity through Everyday Natural Conversations

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEWARK

ORG_NAME: RUTGERS THE STATE UNIV OF NJ NEWARK

ORG_STATE: NJ

PHR: Project Narrative Perturbed lipid metabolism in aging, Alzheimer’s disease (AD), and AD-related neurodegenerative disorders impacts glial lipid storage and overall lipid profiles in brain cells. Elucidating the mechanisms underlying the crosstalk between different lipid metabolic pathways will inform potential therapeutic targets and strategies. This project aims to define the role of TTYH1 in coordinating lipid storage and lipid efflux in glial cells, and its impact on neuronal homeostasis.

PI_NAMEs: WONG, CHING-ON  (contact)

PROJECT_TERMS: Acute;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Apolipoprotein E;Astrocytes;Autophagocytosis;Brain;brain cell;Brain Diseases;brain health;Cellular biology;Ceramides;Coculture Techniques;conditional knockout;Coupled;Cytosolic Phospholipase A2;Disease;Drosophila genus;Dryness;experimental study;fly;functional outcomes;Genes;Genetic Transcription;Health;healthspan;Homeostasis;Homologous Gene;Human;Impairment;in vivo;inhibition of autophagy;insight;Knockout Mice;Late Onset Alzheimer Disease;lipid biosynthesis;lipid metabolism;Lipid Mobilization;lipidomics;Lipids;Lipoproteins;Mediating;Membrane;Metabolic Pathway;Metabolism;model organism;Modeling;Molecular;Molecular Genetics;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;nutrient deprivation;Orthologous Gene;Pathogenesis;Pathway interactions;Phospholipases A;Phospholipids;Process;Protein Isoforms;response;Role;Signal Pathway;Signal Transduction;Sphingolipids;Stress;Tauopathies;Testing;therapeutic target;trafficking;transcriptomics;Weight

PROJECT_TITLE: Role of TTYH1 in mobilizing lipids and ApoE in glia: Implications for brain aging and neurodegeneration


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DURHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: Alzheimer’s Disease [AD] is a progressive degenerative disorder of unclear etiology, though abnormal hypoperfusion, metabolic deficiency, and stroke may enhance AD progression. Our studies will examine the mechanisms leading to abnormal hypoperfusion and metabolism in AD, differentiating effects of aging versus degeneration, in a mouse model of AD. We will study hemodynamic supply of metabolic substrates to the brain and particularly pericytes and cerebrovascular mechanisms, which are signaled by neurons for enhanced blood flow. These studies may lead to treatments which may be able to improve brain metabolism based on identifying relevant mechanisms through manipulation of abnormal neurovascular coupling.

PI_NAMEs: TURNER, DENNIS ALAN (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Affect;Age;age effect;age related;Aging;aging brain;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;analog;Animal Disease Models;Animals;apolipoprotein E-4;Behavioral;Blood capillaries;Blood flow;Blood Vessels;Brain;brain metabolism;Brain Pathology;Cell Wall;cerebrovascular;Cerebrovascular Circulation;Cerebrum;cholinergic;Clinical;constriction;Cyclophilin A;Degenerative Disorder;Dementia;designer receptors exclusively activated by designer drugs;Disease;disease phenotype;Disease Progression;Elements;Etiology;experience;extracellular;Future;G-Protein-Coupled Receptors;Gender;Genes;Genetic;genetic approach;Genotype;Glucose;Glutamates;Goals;hemodynamics;Hippocampus;Human;Hyperemia;hypoperfusion;Hypoxia;improved;In Vitro;in vivo;Intervention;life span;Link;Memory;Metabolic;metabolic rate;Metabolism;metabolomics;Modeling;mouse model;Mus;Neocortex;Nerve Degeneration;neural;Neurons;neurotransmission;neurovascular;neurovascular coupling;novel strategies;patch clamp;Pathologic;Pathway interactions;Pericytes;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Physiological;Physiology;Population;Potassium Channel;pre-clinical;premature;Premature aging syndrome;prevent;progressive neurodegeneration;Regulation;response;Risk Factors;Senile Plaques;Signal Transduction;Slice;spreading depression;Stereotyping;Stroke;Synapses;Syndrome;tau-1;Time;Tissues;Training;translational model;treatment strategy;Vasodilation

PROJECT_TITLE: Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathology


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Through blocking complement activation and proinflammatory cytokines, we have discovered lipidomic and lysosomal defects in microglia as key disease-driving factors that promote neuronal degeneration in frontotemporal lobar degeneration (FTLD) caused by mutations in the GRN gene. Using mouse models and postmortem tissues we will further uncover the role of lipid metabolism in neurodegeneration in FTLD and AD.

PI_NAMEs: HUANG, ERIC J (contact)

PROJECT_TERMS: 3-Dimensional;age related;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Astrocytes;astrogliosis;Automobile Driving;Autophagocytosis;Autopsy;Biochemical;brain tissue;Cell Fractionation;Coculture Techniques;cohort;comparative;Complement;Complement Activation;cytokine;Data;Defect;Disease;dominant genetic mutation;Endosomes;Frontotemporal Lobar Degenerations;GRN gene;Human;Image;induced pluripotent stem cell;Inflammatory;Knock-in Mouse;Knock-out;Knockout Mice;Label;limbic-predominant age-related TDP-43 encephalopathy;lipid metabolism;lipid transport;lipidomics;Lipids;Lysosomes;Mediating;Memory impairment;Microglia;mouse model;Mus;mutant;Mutation;Nature;Nerve Degeneration;neural circuit;neuroinflammation;neuron loss;Neurons;neurotoxic;neurotoxicity;new therapeutic target;Organoids;Pathology;Pathway interactions;Patients;PGRN gene;Phenotype;Phospholipids;Production;Property;protein TDP-43;Proteomics;RNA-Binding Proteins;Role;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;TDP-43 aggregation;Testing;Tissues;Toxic effect;trafficking;transcriptome;Validation;Vesicle;Work

PROJECT_TITLE: Endolysosomal trafficking and lipid metabolism defects in FTLD


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This application has the goal of continuing to provide education and training to nurses at the predoctoral and postdoctoral level in the field of omics research. Nurses are uniquely positioned to bridge the gap between omics research and clinical practice. They interact with patients at all stages of life, and in all clinical arenas. There continue to be few opportunities for long-term laboratory-based training in the conduct of cutting-edge omics research and such training opportunities are essential because nearly every condition studied by nurse scientists has an omics component. Our objective is to train talented Nurse Scientists, at the beginning stages of their careers, to develop research trajectories related to the application and evaluation of omics in improving patient outcomes.

PI_NAMEs: CONLEY, YVETTE P (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Academic Training;Genomics;Nurses;Research Training;Targeted Research

PROJECT_TITLE: Targeting Research and Academic Training of Nurses in Genomics


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pain Research;Primary Health Care;Rehabilitation;Social Determinants of Health;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE People attending federally qualified health centers (FQHCs) typically have limited access to acupuncture, an evidence-based symptom management intervention. This study will assess the feasibility of implementing acupuncture at an FQHC to alleviate multiple symptoms experienced by breast cancer survivors during endocrine therapy. Long-term, this study is the first step toward ensuring equal access to this evidence-based intervention. Results will provide the foundation for rigorous studies to test the effectiveness of integrating acupuncture into FQHC oncology clinic to support medically underserved breast cancer survivors.

PI_NAMEs: LI, HONGJIN  (contact)

PROGRAM_OFFICER_NAME: JEAN-FRANCOIS, BEDA

PROJECT_TERMS: acceptability and feasibility;Acupuncture Therapy;Address;Adherence;adjuvant endocrine therapy;Affect;Agreement;anastrozole;Anxiety;Arthralgia;associated symptom;Attention;barrier to care;Breast Cancer survivor;Cancer Survivor;Caring;chemotherapy;chronic pain management;Clinic;common symptom;Complementary Health;Consolidated Framework for Implementation Research;cost;Data;Diagnosis;Distress;effectiveness testing;effectiveness/implementation trial;efficacy evaluation;Ensure;ethnic discrimination;evidence base;Evidence based intervention;Evidence based treatment;experience;Face;Fatigue;feasibility testing;Federally Qualified Health Center;Foundations;functional status;Goals;health care availability;health disparity;Health Insurance;Health Services Accessibility;Hormonal;hormone therapy;Hot flushes;implementation process;improved;Income;Individual;Insurance Coverage;Integrative Medicine;Integrative Therapy;Intervention;Interview;Low Back Pain;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medicaid;medically underserved;Medicare;Mental Depression;Mental Health;Methods;Neighborhoods;Oncology;Output;Pain;Participant;Patients;Persons;Polypharmacy;Primary Care;primary outcome;Privatization;Quality of life;racial discrimination;Randomized;Randomized, Controlled Trials;recruit;Regimen;Reporting;Research;research study;Risk;satisfaction;Services;side effect;Site;Sleep disturbances;social health determinants;Socioeconomic Status;stem;Structure;Surveys;symptom cluster;symptom management;Symptoms;Tamoxifen;targeted therapy trials;Testing;Transportation;treatment as usual;Treatment Efficacy;underserved community;United States;Woman;Work

PROJECT_TITLE: Feasibility of Implementing Acupuncture into a Federally Qualified Health Center to Alleviate  Multiple Symptoms Among Breast Cancer Survivors Receiving Endocrine therapy


PHR: Narrative This application requests support for pre- and post-doctoral research training for nurse scientists to build careers directed at understanding and improving health across the life span.

PI_NAMEs: HAPP, MARY E;PICKLER, RITA H (contact)

PROJECT_TERMS: Development;Health Sciences;Training

PROJECT_TITLE: Training in the Science of Health Development


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Genetics;Natural Products

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Plant natural products are the source of ~25% of FDA-approved drugs but drug discovery and development from plants is challenging due to rediscovery of known compounds and difficult scaled production and diversification of lead structures. To overcome these bottlenecks, the proposed research will develop a gene-guided approach to systematically discover new cyclic peptide natural products from plants by (a) mining plant genomes for new peptide biosynthetic genes, (b) biosynthesis of plant peptide lead structures via new plant peptide cyclases and (c) production of plant peptide libraries from diversified plant peptide precursor genes. Cyclic plant peptides are an attractive test case for gene-guided discovery of plant natural product drugs as they constitute lead structures for antiviral and anticancer therapy due to high oral bioavailability, stability and target specificity.

PI_NAMEs: KERSTEN, ROLAND DAVID (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Alkaloids;Anabolism;analog;anti-cancer;Biological Assay;Biological Availability;C-terminal;cancer therapy;Cells;Celosia;Chemicals;Chinese;Complex;Copper;Cyclic Peptides;design;Development;drug development;drug discovery;Engineering;Enzymes;Family;FDA approved;Genes;Genetic;genetic information;genome resource;guided inquiry;In Vitro;in vivo;Lead;Libraries;manufacturing facility;Mass Spectrum Analysis;Medicinal Plants;Medicine;metabolomics;microbial;Mining;Modification;Molecular;Natural Product Drug;Natural Products;Oral;Organic Synthesis;Organism;Pathway interactions;Peptide Library;Peptides;Periodicity;Pharmaceutical Preparations;Pharmacologic Substance;Plant Extracts;Plant Genes;plant genetics;Plant Genome;plant growth/development;plant metabolites;Plant natural product;Plant Sources;Plants;Production;Research;Route;Source;Specificity;Structure;synthetic biology;tandem mass spectrometry;Technology;Tertiary Protein Structure;Testing;therapeutic evaluation;transcriptome;Trees;Tryptophan;Tyrosine;Viral;Viral Cancer;Ziziphus

PROJECT_TITLE: Discovery, Biosynthesis and Engineering of Side-Chain-Macrocyclic Plant Peptides


NIH_SPENDING_CATS: Genetics;Human Genome;Regenerative Medicine;Wound Healing and Care

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: The biggest biomedical challenge of this century is the restoration of diseased organs and tissues. Unlike humans, salamanders have the extraordinary ability to rapidly regenerate organs, including limbs, spinal cords, hearts and brains. Our goal is to discover how these animals rebuild functional adult tissues in a matter of weeks.

PI_NAMEs: BARNA, MARIA  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Adult;Ambystoma;Ambystoma mexicanum;Amputation;Animals;Binding Sites;Brain;Cell Fate Control;cell fate specification;Cell Proliferation;Cell Survival;Cells;Complex;Cytoplasmic Granules;Development;Digit structure;Disease;Evolution;Exhibits;Foundations;FRAP1 gene;Genetic Transcription;genome-wide;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;healing;Health;Heart;Human;human tissue;Injury;Knock-in;limb amputation;limb regeneration;Limb structure;Lysosomes;Mammals;Membrane;Messenger RNA;Methods;Molecular;mouse model;mRNA Translation;Mus;Natural regeneration;novel;Organ;organ regeneration;Organism;Pathway interactions;Phosphotransferases;Polyribosomes;polysome profiling;Production;protein activation;Protein Biosynthesis;Proteins;recruit;regeneration potential;regenerative;Regulation;repaired;Resolution;response;Rest;restoration;Ribosomal Proteins;ribosome profiling;Ribosomes;RNA, Messenger, Stored;Role;Salamander;Science;selective expression;severe injury;Signal Transduction;Site;Spinal Cord;Stress;Stress Response Signaling;Structure;Technology;Testing;Time;tissue regeneration;Tissues;tool;Transcript;transcriptome;transcriptome sequencing;Translating;Translational Activation;translational impact;Translational Regulation;Translational Research;Translations;translatome;Vertebrates;wound healing

PROJECT_TITLE: Rapid remodeling of the translatome underlying wound healing and regeneration

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Infectious Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE The goal of this project is to understand how a fungal meningitis pathogen, Cryptococcus neoformans, manipulates the innate immune system to enable infection. We have identified a protein secreted by this fungal pathogen that converts macrophages, key cells of the immune system, into an ineffective state. Deciphering how this is accomplished at the molecular level has the potential to transform our understanding of invasive fungal infections.

PI_NAMEs: MADHANI, HITEN D (contact);MOLOFSKY, ARI B

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Alveolar Macrophages;arginase;B-Lymphocytes;Binding;Biochemical;Bone Marrow;CD14 Antigen;Cells;Chimera organism;ChIP-seq;Confocal Microscopy;Coupled;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Cytokine Signaling;Data;Diagnosis;Down-Regulation;effector T cell;experimental study;extracellular;Flow Cytometry;forward genetics;Fungal Meningitis;Goals;Growth;Hand;Image;Immune;Immune response;Immune system;Immunity;Immunology;In Vitro;in vivo;Incubated;Infection;Inflammatory;innate immune mechanisms;Innate Immune System;Interleukin-13;Interleukin-4;interstitial;Knock-out;Lead;Ligands;Lung;Macrophage;Mediating;Mediator;Methods;Modality;Modeling;Molecular;monocyte;Mus;Mycoses;Myeloid Cells;Natural Immunity;neutrophil;pathogen;Pathogenesis;pathogenic fungus;Pathway interactions;Population;predictive modeling;Predisposition;programs;Protein Secretion;Proteins;Recombinants;recruit;Reporter;response;Role;Salmonella;Signal Transduction;Site;STAT3 gene;STAT6 gene;STAT6 Transcription Factor;Structure of germinal center of lymph node;Surface;T cell response;Testing;Thick;Tissues;TLR4 gene;Up-Regulation;Virulence;Work

PROJECT_TITLE: Manipulation of macrophage polarization by a fungal meningitis pathogen

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: TROY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: The left-right organizer plays a critical role in animal asymmetry, deviation from which results in severe birth defects, but its biophysical mechanisms are not well understood, especially for humans. We propose to develop a stem cell-based in vitro human organizer and to study the mechanisms of chiral structural formation.

PI_NAMEs: WAN, LEO Q. (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Animals;Basic Science;Biomedical Engineering;Biomimetics;Biophysical Process;Cardiac;Cell Differentiation process;Cell Polarity;Cells;Chick;Cilia;Clinical;Congenital Abnormality;Defect;Development;Devices;differentiation protocol;Diffusion;Embryo;Embryoid bodies;Embryonic Development;Engineering;Ethics;experience;Extracellular Matrix;fascinate;Fishes;Handedness;Healthcare;Human;Human body;human embryonic stem cell;Human Engineering;Hydrogels;In Vitro;Individual;interest;Isomerism;Left;Live Birth;Mechanics;Modeling;Morphogenesis;morphogens;Morphology;Motion;Mus;novel;Organ;Organ Model;organ on a chip;Organoids;Pattern;Pharmaceutical Preparations;planar cell polarity;Play;Positioning Attribute;Premature Birth;prenatal;Process;Regulation;Research;Research Personnel;Role;Scientific Advances and Accomplishments;Scientist;screening;Shapes;Side;Signal Transduction;Spontaneous abortion;stem cell biology;stem cell fate;stem cells;Structure;System;Techniques;Teratogens;three-dimensional modeling;Tissue Engineering;Training;Vertebrates;Xenopus

PROJECT_TITLE: Engineering Human Organizer To Study Left-Right Symmetry Breaking

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE: HIV-1 is able to persist in the face of effective antiretroviral therapy (ART). Identification of cellular reservoirs that support viral persistence are needed to guide the design of viral cure strategies. While HIV-1 can infect T cells and myeloid cells such as microglia, there are few studies being explored to assess the role of myeloid cells in viral persistence. The proposed studies employ novel tools developed by us that allow interrogation of myeloid cell reservoirs in anatomic sites such as the CNS and that have the capacity to reveal the role played by myeloid cells in HIV-1 persistence.

PI_NAMEs: STEVENSON, MARIO  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: acute infection;Affinity;Anatomy;antiretroviral therapy;Area;Binding;CD4 Antigens;CD4 Positive T Lymphocytes;cell mediated immune response;Cell membrane;Cells;Cellular Immunity;Chronic;Clinical;cohort;Cytoprotection;defined contribution;design;Evolution;Frequencies;Funding;Glean;Glycoproteins;high risk population;high throughput analysis;HIV Genome;HIV-1;HIV/AIDS;Immunity;Immunologic Surveillance;Individual;Infection;insight;Interruption;Kinetics;Ligands;Location;Longevity;Lymphoid;Macrophage;Male Genital Organs;Mediating;Membrane;Methods;Microglia;molecular clock;Myelogenous;Myeloid Cells;Nature;novel;novel strategies;Plasma;Plasma Cells;Play;Population;pressure;Proteomics;reproductive tract;Research;Role;Sampling;Source;T-Lymphocyte;T-Lymphocyte Epitopes;Tissues;tool;Variant;Viral;viral rebound;Viral reservoir;Viremia;Virion;Virus

PROJECT_TITLE: Revealing HIV-1 persistence in myeloid cell reservoirs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-H(02)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Precision Medicine

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative The proposed work is relevant to public health because it is expected to identify disease-modifying gene variants (alleles) that can be tested in patients to help clinicians deliver personalized medicine. Gaining knowledge of these modifier alleles will accelerate the advancement of the medical genomics field beyond the perspective of single disease-causing genes to a point of view that considers multiple modifier genes when understanding diseases. 1

PI_NAMEs: LIU, PENGFEI  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: 17q12;1q21;Acceleration;Alleles;candidate identification;Clinical;clinical diagnostics;clinically significant;cohort;Copy Number Polymorphism;Counseling;Data;Databases;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;disease phenotype;disease-causing mutation;DNA Sequence Rearrangement;early onset;Enhancers;Genes;Genetic;Genetic Determinism;Genetic Diseases;genetic variant;Genome;genome sequencing;genomic locus;Genomics;Genotype;Goals;Head;Human;human disease;human subject;individual patient;innovation;Knowledge;Medical;Mendelian disorder;Modeling;Molecular;patient derived induced pluripotent stem cells;Patient Recruitments;Patients;Penetrance;personalized medicine;Phenotype;precision genomic medicine;Public Health;Recurrence;Research;Resources;Role;Sequence Deletion;Testing;Validation;Variant;whole genome;Work

PROJECT_TITLE: Characterizing disease-causing variants using personal genomes with large recurrent deletions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Sleep Research;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

PHR: We propose a series of translational studies that are aimed to improve our understanding or the role of near-infrared light in reducing the Alzheimer’s disease pathology as well as to identify the way of near- infrared light delivery that is most efficient in treating Alzheimer’s disease.

PI_NAMEs: GERASHCHENKO, DMITRY  (contact)

PROJECT_TERMS: absorption;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Animals;APP-PS1;Arteries;Astrocytes;awake;Blood Vessels;Brain;Brain region;brain tissue;Cell Culture Techniques;Cerebral Ischemia;Cerebrovascular Circulation;Clinical Trials;clinically significant;Data;Dependence;design;Disease Progression;Elements;Endothelial Cells;Endothelium;experimental study;Exposure to;Frequencies;Generations;glymphatic flow;glymphatic system;Hippocampus;improved;interest;Ischemic Brain Injury;Knock-in;Knock-out;Light;Measures;Mediator;Memory;Metabolic;Metabolic Clearance Rate;mouse model;multiphoton microscopy;Mus;neuroblastoma cell;Neurons;Nitric Oxide;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;non rapid eye movement;NOS3 gene;novel strategies;offspring;Pathology;Penetration;Performance;Phosphorylation;photobiomodulation;Phototherapy;Play;Process;Production;Property;Proteins;Publishing;Pulsatile Flow;Relaxation;REM Sleep;Role;Senile Plaques;Series;Sleep;System;tau Proteins;Testing;Therapeutic Effect;Tissues;Transgenic Mice;translational study;Vasodilation;vasomotion;virtual;Wakefulness;wasting

PROJECT_TITLE: Sleep-dependent mechanisms of improving cerebral blood flow and reducing Alzheimer's disease progression by photobiomodulation with near-infrared light


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Although astrocytes, the most abundant glia cells in the brain, have been proposed to play important roles in the neural circuitry and behaviors, a mechanistic and comprehensive understanding of the active functional roles of astrocytes in neural circuitry and behaviors is largely lacking partially due to the difficulty in modeling the complex astrocyte activity data. We thus propose to apply advanced machine learning and data science theory to develop advanced computational methods and analytical tools. A deep understanding of bi-directional astrocyte-neuron signaling in health and disease could lead to novel therapies for brain disorders.

PI_NAMEs: WANG, YUE  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: analytical tool;Astrocytes;Award;Behavior;Behavioral;Biological;Blood Vessels;Brain;brain disorder therapy;BRAIN initiative;Breathing;Calcium;calcium indicator;cell type;Cells;Collaborations;Communication;Complex;Computer Models;Computer software;computerized tools;Computing Methodologies;Consensus;Data;Data Science;Data Set;Development;Dimensions;Disease;Event;experimental study;extracellular;Feedback;flexibility;Fluorescence;Funding;Goals;Health;Hour;Human;human induced pluripotent stem cells;Image;imaging capabilities;improved;in silico;Individual;insight;laboratory experiment;Learning;Link;Machine Learning;Membrane;Memory;method development;Methods;Microglia;Microscopy;millisecond;Modeling;Modernization;Morphology;Motor;multidisciplinary;multiplexed imaging;Mus;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neuroglia;neuronal circuitry;Neurons;neuropsychiatric disorder;neurotransmission;new therapeutic target;Noise;novel;novel therapeutics;Oligodendroglia;Outcome;Paper;Parkinson Disease;Pathologic;Pattern;Pharmaceutical Preparations;Phosphotransferases;Physiological;Play;Positioning Attribute;Protocols documentation;prototype;receptor;Role;Science;Scientist;Signal Induction;Signal Transduction;Sleep;Software Engineering;Speed;Statistical Models;stem cell model;success;Synapses;synaptic function;Techniques;Testing;theories;therapeutic target;Time;tool;transmission process;Treatment Efficacy;user-friendly;Vertebral column;vigilance;visual motor;Work;Zebrafish

PROJECT_TITLE: Decoding Astrocyte Signaling in Neural Circuitry with Novel Computational Modeling and Analytical Tools

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Project Narrative Lipid accumulation is one of the major pathological features in the brain of patients with Alzheimer’s dementia (AD). This project will identify specific brain lipid species associated with cognitive decline and AD pathologies using postmortem brain tissue samples collected by two large population cohorts of aging and dementia. Such results will help us understand why lipid accumulation in the aging brain affects AD and are likely to lead to novel therapeutics for AD prevention and treatment.

PI_NAMEs: ZHAO, JINYING  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid beta-Protein;Autopsy;Bioinformatics;Blood;blood lipid;Blood specimen;Brain;Brain Mapping;brain tissue;carrier status;Cellular Membrane;Clinical;Cognition;Cognitive;Cognitive aging;cognitive testing;cohort;Collection;Communities;Complex;Custom;Cytoplasmic Granules;Data;Dementia;Disease;DNA;DNA Methylation;epidemiology study;epigenomics;Freezing;Functional disorder;genome wide association study;Genomics;Glycerophospholipids;Goals;Human;Impaired cognition;Individual;innovation;Knowledge;Libraries;lipid metabolism;lipidome;lipidomics;Lipids;Longitudinal cohort;Mass Spectrum Analysis;Measures;Memory;Meta-Analysis;MicroRNAs;Molecular;Multiomic Data;multiple omics;Multivariate Analysis;Neurofibrillary Tangles;neuroinflammation;neuropathology;novel therapeutics;older adult;Pathogenesis;Pathologic;Pathology;Patients;Persons;Phenotype;Play;Population;Population Study;Prefrontal Cortex;Prevention;Prospective cohort;Regulation;religious order study;Reporting;Role;Sample Size;Sampling;Senile Plaques;sex;Signal Transduction;Specimen;Spectrometry;Spectrum Analysis;Sphingolipids;Synapses;tau Proteins;Tauopathies;Techniques;Technology;Tissue Sample;Tissues;transcriptome sequencing;transcriptomics;Variant;Work

PROJECT_TITLE: Brain lipids and AD


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Prevention;Rare Diseases

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Although signaling and endocytic trafficking of the epidermal growth factor receptor have been studied in the context of mitogenic activation of cells and tumorigenesis, the molecular events that regulate EGFR levels and signaling, and their contribution to oral tumorigenesis are largely unknown. Studies proposed in this application will determine, for the first time, how an essential centriole biogenesis protein, CPAP regulates the ESCRT pathway to suppress EGFR signaling, and prevent EMT and tumorigenesis in oral cancer, independent of its function on the centrioles.

PI_NAMEs: GUDI, RADHIKA ;VASU, CHENTHAMARAKSHAN  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: ATP phosphohydrolase;beta catenin;Binding;Biogenesis;Biological;cancer cell;cancer stem cell;Carrier Proteins;Cell Line;Cells;Centrioles;Centrosome;Chemoresistance;chemotherapy;Clinical;Co-Immunoprecipitations;Complex;Data;Defect;Development;Down-Regulation;Drug Targeting;Endocytic Vesicle;Endocytosis;Endosomes;Epidermal Growth Factor Receptor;epithelial to mesenchymal transition;Epithelium;Event;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;gain of function;Generations;Genetic Models;Goals;Growth;Growth Factor;Homeostasis;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Ligands;Link;loss of function;Lysosomes;Malignant - descriptor;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Mesenchymal;Microtubule-Associated Proteins;Microtubules;Molecular;mouth squamous cell carcinoma;Multivesicular Body;Mutagenesis;Neoplasm Metastasis;new therapeutic target;Nitroquinolines;novel;Oral;oral carcinogenesis;oral tumorigenesis;overexpression;Oxides;Pathway interactions;Patients;Phenotype;Physiological;Predisposition;prevent;Prevention;Preventive;Printing;Proliferating;Property;protein function;Protein Overexpression;Proteins;receptor;Receptor Down-Regulation;receptor downregulation;receptor expression;Receptor Signaling;recruit;Recurrence;Regulation;Resistance;Role;Route;Signal Transduction;Solid;Sorting;Structure;Surface;Survival Rate;Testing;therapeutic target;Time;Tissues;trafficking;Translating;Tubulin;Tubulin Interaction;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic;Tumorigenicity;Unfavorable Clinical Outcome;validation studies;Vesicle;vesicle transport

PROJECT_TITLE: ESCRT-dependent novel regulatory mechanism of EMT and tumorigenesis in oral cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

PHR: PUBLIC HEALTH RELEVANCE: The projects outlined in this renewal application address brain mechanisms through which the heritable risk for alcoholism evolves into human alcohol use disorder. In so doing, it may guide the development of novel preventive strategies. It addresses the public health impact of alcoholism by testing novel treatments for pathological drinking.

PI_NAMEs: KRYSTAL, JOHN H. (contact)

PROGRAM_OFFICER_NAME: EGLI, MARK

PROJECT_TERMS: Achievement;Address;Alcohol consumption;alcohol research;alcohol risk;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholism;Alcohols;Animals;Attenuated;Basic Science;Behavioral;Brain;career development;Chemicals;Clinical;Clinical Research;Corpus striatum structure;Development;Doctor of Medicine;drinking;Education;Ethics;Faculty;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Heritability;high risk;Human;Infrastructure;innovation;insight;International;Learning;metabotropic glutamate receptor 5;Mission;Modeling;Molecular;Molecular Genetics;N-Methylaspartate;National Institute on Alcohol Abuse and Alcoholism;neural circuit;neurochemistry;neuroimaging;Neurosciences;Neurosciences Research;novel;Pathologic;Pilot Projects;Postdoctoral Fellow;preclinical study;Prevention strategy;Productivity;Psychopharmacology;Public Health;public health relevance;Regulation;Research;Research Personnel;Research Support;Research Training;Rewards;Risk;Scientist;Self Administration;Services;Signal Transduction;Signaling Protein;Students;success;symposium;Testing;therapeutic evaluation;translational neuroscience;translational research program;Up-Regulation

PROJECT_TITLE: Center for the Translational Neuroscience of Alcoholism


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Neurosciences;Patient Safety;Substance Misuse

PROJECT_TERMS: Advisory Committees;Alcoholism;career development;Charge;Clinical;Clinical Trials Data Monitoring Committees;Data;Doctor of Medicine;Education;executive function;Faculty;Mission;Monitor;Neurosciences;novel;Pilot Projects;preservation;programs;Research;Research Training;Safety;translational goal;translational neuroscience

PROJECT_TITLE: Administrative Core


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Inheritance of the apolipoprotein (APO) E4 gene is the strongest genetic risk factor identified to date for late onset Alzheimer's disease (AD), an age-related debilitating brain disorder that afflicts more than six million Americans and their families. Although the mechanisms by which APOE4 modifies the risk of AD are not fully understood, compelling evidence indicates that the pathogenic effects of APOE4 are mediated by lipid-related pathways involving the cell's powerhouse – mitochondria. The present study aims to assess the impact of mitochondrial lipidomic dynamics and its interaction with different APOE isoforms on brain aging and the progression of AD and identify novel molecular targets and/or pathways that can be harnessed as diagnostic biomarkers and/or for therapeutic development to block pathogenic brain aging and AD.

PI_NAMEs: LI, DANNI ;LI, LING  (contact)

PROJECT_TERMS: Acceleration;acylcarnitine;Affect;Age;age related;aging brain;aging population;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;American;Amyloid deposition;amyloid pathology;Amyloidosis;Animal Model;apolipoprotein E-3;apolipoprotein E-4;APP-PS1;Astrocytes;Autopsy;Behavioral;Brain;Brain Diseases;brain tissue;Cell Fractionation;Cell model;Cell Nucleus;Cell Physiology;cell type;Cells;Cerebrum;Clinical;Cognition;Cognitive deficits;cognitive function;Coupled;Data;Dementia;Development;diagnostic biomarker;disease phenotype;Energy Metabolism;Evaluation;Family;Genes;genetic risk factor;Genotype;Homeostasis;Human;human old age (65+);human tissue;Impaired cognition;Impairment;Individual;Induced pluripotent stem cell derived human neuron;innovation;Knock-in;Late Onset Alzheimer Disease;Lead;lipidome;lipidomics;Lipids;Literature;Mediating;Metabolic;metabolomics;middle age;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Target;mouse model;multiple omics;Mus;Nerve Degeneration;Neurobehavioral Manifestations;Neuroglia;Neurons;neuropathology;neurotoxicity;novel;Organelles;Organoids;Participant;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Patients;Phospholipase A2;Plasma;Population;Presynaptic Terminals;Prevalence;Protein Isoforms;religious order study;Research;Severities;sex;Specimen;Structure;Synapses;Technology;Testing;therapeutic development;Three-Dimensional Imaging;Tissue Sample;transcriptomics;Transgenic Organisms;Wild Type Mouse

PROJECT_TITLE: Impact of Mitochondrial Lipidomic Dynamics and its Interaction with APOE Isoforms on Brain Aging and Alzheimers Disease


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

PI_NAMEs: TAYLOR, JANE R (contact)

PROJECT_TERMS: Abstinence;addiction;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol seeking behavior;alcohol use disorder;Alcoholism;Alcohols;antagonist;Attenuated;Behavior;Behavioral;behavioral impairment;Behavioral Mechanisms;Choice Behavior;clinical investigation;Clinical Research;Corpus striatum structure;Cues;Data;Decision Making;Development;drinking behavior;Drug usage;effective intervention;Female;Fiber;flexibility;Functional disorder;glutamatergic signaling;Glutamates;Goals;habit learning;Habits;Human;Impairment;improved;insight;Laboratories;Learning;learning strategy;Link;male;Measures;Mediating;Mission;Modeling;Motivation;Mus;neural;neural circuit;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;novel;novel therapeutics;Nucleus Accumbens;Outcome;Patients;Pharmaceutical Preparations;Photometry;pre-clinical;Prefrontal Cortex;Process;Proxy;Psychological reinforcement;Public Health;Publishing;receptor;Relapse;remediation;Reporting;Research;response;Rodent;Rodent Model;Role;Self Administration;sex;Sex Differences;Signal Transduction;System;Techniques;Testing;Therapeutic;Therapeutic Effect;translational neuroscience;Translational Research

PROJECT_TITLE: Behavioral and Neural Mechanisms Underlying the Therapeutic Effects of Mavoglurant in AUD


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This project is relevant to public health because the discovery and characterization of enzymes that degrade the polysaccharides of fungal cell walls will enable the development of novel anti-fungal therapies able to treat drug-resistant infections. Consequently, the proposed research is relevant to NIH’s mission because future applications of the fundamental knowledge gained from this project have the potential to decrease mortality and treatment costs caused by fungal diseases.

PI_NAMEs: GARDNER, JEFFREY  (contact)

PROJECT_TERMS: Acceleration;anti-fungal agents;Antifungal Therapy;Aspergillus nidulans;Bacteria;Basic Science;Biological Assay;Biomass;candidate identification;Cell Wall;Cells;Cellvibrio;Chitin;Chitinase;combat;Complex;Complex Mixtures;Containment;Coupled;Data;depolymerization;design;Development;Disease;Drug resistance;Ensure;Enzymatic Biochemistry;Enzymes;Excision;fitness;fitness test;Fungal Components;Fungi Model;fungus;Future;gene complementation;Gene Deletion;Gene Expression;gene product;Genes;genetic analysis;Glucans;Goals;Growth;Health;Human;In Vitro;in vivo;Incidence;Individual;Infection;innovation;insight;Kinetics;Knowledge;Measurement;Medical;Medical Device;Methods;Microbial Biofilms;Mission;Modeling;Molds;mortality;multiple omics;mutant;Mutation;Mycoses;Nature;novel;novel strategies;Nutrient;Ointments;Outcome;pathogenic fungus;Pattern;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Polysaccharides;poor health outcome;prevent;Property;protein expression;Proteins;Proteome;Proteomics;Public Health;rational design;Regulation;Research;Research Project Grants;Resistance;Saccharomyces cerevisiae;Source;Structure;Substrate Specificity;synergism;System;Systems Biology;Techniques;Testing;Therapeutic;Time;transcriptome;transcriptomics;Treatment Cost;United States National Institutes of Health;Yeasts

PROJECT_TITLE: Characterization of bacterial enzymes that depolymerize fungal cell wall polysaccharides

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative For people living with HIV (PLWH), achieving, and maintaining viral suppression has critical benefits for their health and for reducing the risk of transmitting HIV to others. Viral suppression is thus a critical cornerstone of the US program to end HIV, but over a third of people in the US living with HIV do not have a suppressed viral load. We propose to use observational epidemiology methods to develop a nuanced understanding of the circumstances that surround gaining, sustaining, or losing viral suppression in men who have sex with men and transfeminine people.

PI_NAMEs: SIEGLER, AARON JULIUS;SULLIVAN, PATRICK SEAN (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: acceptability and feasibility;aged;Attention;Behavior;black men who have sex with men;Black Populations;Black race;Blood specimen;care seeking;Caring;Characteristics;Cities;cohort;Collaborations;Communities;community-level factor;Data;Decision Making;Detection;Development;Discrimination;effective intervention;Enrollment;Environment;Epidemic;Epidemiologic Methods;experience;Frequencies;gender minority group;Geography;Health;health care settings;Health Personnel;Hispanic;HIV;HIV Infections;Individual;Intervention;Interview;Measures;Medical;men who have sex with men;Methods;Modeling;Monitor;multilevel analysis;Neighborhoods;Observational epidemiology;outcome disparities;Participant;Pattern;Persons;Policies;prevent;programs;racial disparity;Recommendation;recruit;remote grading;remote monitoring;Research;research study;resilience;Risk;Risk Reduction;sample collection;Sampling;Sex Behavior;Sexual and Gender Minorities;Sexual Partners;Shapes;social;social stigma;socioeconomics;Structural Racism;Subgroup;substance use;Testing;therapy design;Time;transfeminine;transgender;transmission process;Viral;Viral Load result;virtual;young men who have sex with men

PROJECT_TITLE: Limited interaction cohort to identify determinants of viral suppression in MSM and transfeminine individuals living with HIV: A multilevel approach


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Prevention;Substance Misuse

PI_NAMEs: PEARLSON, GODFREY D (contact)

PROJECT_TERMS: Acute;Affect;alcohol abuse therapy;Alcohol consumption;alcohol cue;alcohol response;alcohol risk;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholism;Alcohols;Animals;Attenuated;Basal Ganglia;Behavior;Behavioral;Binding;Biology;Brain;brain abnormalities;Brain region;causal model;Chronic;cognitive control;Coupled;Cross-Over Studies;cue reactivity;Cues;Decision Making;disorder risk;Dopamine;Dose;Double-Blind Method;drinking;Drug Targeting;Evaluation;executive function;Family;Family history of;financial incentive;frontal lobe;Functional Magnetic Resonance Imaging;Genetic Risk;Glutamate Receptor;Glutamates;Goals;Habits;Hippocampus;Human;Image;Impairment;Impulsivity;Individual;Inherited;inhibitor;insight;Investigation;Laboratories;Laboratory Study;Learning;learning strategy;Link;Measures;Medial;Modeling;Morbidity - disease rate;mortality;N-Methylaspartate;neural circuit;Neurobiology;neuroimaging;Neurotransmitter Receptor;novel;Nucleus Accumbens;Operant Conditioning;Participant;Pattern;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phase;Placebo Control;Placebo Effect;Placebos;Positron-Emission Tomography;pre-clinical;Psychological reinforcement;Punishment;Randomized;Recording of previous events;Research;response;Rewards;Risk;Role;Sarin;Signal Transduction;social;soft drink;Specificity;Substance abuse problem;System;Task Performances;Testing;Therapeutic;Therapeutic Effect;translational neuroscience;Variant;Visit

PROJECT_TITLE: Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor, Mavoglurant.


ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: We propose a new imaging technique for tumor detection based on a molecule that is present on the blood vessel walls of most tumors, both primary and metastatic. The method is expected to detect very small, incipient tumors, at the stage for which the chance of successful treatment is very high. This pilot project is aimed at evaluating the performance of the method using mice, in preparation for translation to clinical studies.

PI_NAMEs: RADU, AURELIAN  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Affinity;Anatomy;anti-cancer research;Antibodies;Binding;Blood;Blood Vessels;bone;Brain;cancer clinical trial;Cancer Diagnostics;cancer imaging;cancer predisposition;cancer therapy;cancer type;Cell Culture Techniques;Cells;Circulation;Clinical;Clinical Research;clinical translation;Complex;cost;Coupled;Data;Detection;detection sensitivity;Development;Diameter;Early Diagnosis;Elements;Excision;Fc Receptor;Follicle Stimulating Hormone Receptor;Future;General Population;high risk;Hormones;Human;Image;imaging agent;imaging detection;imaging modality;Imaging Techniques;Immunoglobulin G;Immunohistochemistry;Implant;Incentives;Injections;intravenous injection;iron oxide;Label;Life Style;Ligands;Location;Magnetic Resonance Imaging;Magnetism;Malignant Neoplasms;Medical center;Methods;Modeling;Modification;Monoclonal Antibodies;mortality;Mus;Neoplasm Metastasis;Neoplasms in Vascular Tissue;neoplastic cell;Nutraceutical;Organ;particle;patient screening;patient subsets;Patients;Performance;performance tests;Periodicals;Pharmaceutical Preparations;Pilot Projects;pre-clinical;Preparation;Procedures;programs;Publishing;Reporting;Reticuloendothelial System;Risk;Screening for cancer;Signal Transduction;Surface;Syndrome;System;targeted imaging;Technology;Testing;Tissues;Translations;tumor;Tumor Cell Line;tumor DNA;Tumor Markers;tumor xenograft;Visualization;Work

PROJECT_TITLE: A new highly sensitive targeted imaging method for early tumor detection


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Genetics

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative Tissue resident macrophages (TRMs) are sentinels of the environment that maintain organ homeostasis, yet they remain refractory to standard experimental approaches limiting our understanding of their underlying regulatory mechanisms. We developed a discovery pipeline combining functional genetics with a unique ex- vivo model of lung-specific TRMs, alveolar macrophages, that will enable fundamental discoveries of the TRM functions and maintenance. My research program will leverage these tools to identify new signaling pathways, transcriptional networks and functional mechanisms required for TRMs to maintain tissue homeostasis.

PI_NAMEs: OLIVE, ANDREW  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: Genetic Mechanisms of Tissue-Resident Macrophage Maintenance and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: EB

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cerebrovascular;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative:  Endovascular neurointerventions are critical for treating unruptured aneurysms; however, many such surgical procedures fail due to an inability to maneuver microcatheters safely through tortuous or complex cerebral anatomies. The goal of this research is to engineer and evaluate 3D-nanoprinted microfluidic circuitry- based soft robotic microcatheters that enable real-time multi-directional steering and navigation control by the neurointerventionalist. We expect to improve catheterization efficacy while reducing complication rates in the treatment of cerebral aneurysms.

PI_NAMEs: SOCHOL, RYAN DANIEL (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: 3-Dimensional;3D Print;Address;Anatomy;Aneurysm;Angiography;Animal Model;Blood Vessels;Canis familiaris;Catheterization;Catheters;Cerebral Aneurysm;cerebrovascular;cerebrovascular surgery;Cerebrovascular system;Cerebrum;Cessation of life;Childhood;Clinical;clinically relevant;Complex;Complication;Congenital Heart Defects;Craniotomy;Death Rate;design;Devices;Dissection;Distal;Engineering;General Population;Geometry;Goals;high risk;improved;improved outcome;In Vitro;in vitro Model;in vivo;Infrastructure;innovation;Intervention;Intracranial Hemorrhages;Ischemia;Lasers;Length of Stay;Location;Machine Learning;machine learning framework;manufacture;Measures;Medical;Methods;Microfluidics;microrobot;minimally invasive;Morbidity - disease rate;Nanomanufacturing;Neurologic;neurosurgery;Neurosurgical Procedures;novel;operation;Operative Surgical Procedures;Outcome;Patients;Perforation;Performance;predictive modeling;Printing;procedure safety;Procedures;Reporting;Research;Resolution;Risk;Robot;Robotics;Running;Rupture;Safety;safety and feasibility;Scheme;Side;Specialist;Stents;Subarachnoid Hemorrhage;Surgical Clips;System;Techniques;Technology;Testing;Time;Transistors;Tube;two-photon;Vasospasm;Writing

PROJECT_TITLE: 3D-Nanoprinted Soft Robotic Microcatheters with Integrated Microfluidic Circuitry for Cerebrovascular Surgery

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurosciences;Substance Misuse

PI_NAMEs: KRISHNAN-SARIN, SUCHITRA  (contact)

PROJECT_TERMS: Abstinence;Acute;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol cue;alcohol effect;alcohol exposure;alcohol response;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholic Intoxication;Alcoholism;Alcohols;Ambulatory Care;Animals;antagonist;Attenuated;Autopsy;Behavior;Behavioral Sciences;Beverages;Biological Availability;Brain;Chronic;Clinical;clinical examination;Conceptions;Consumption;Corpus striatum structure;craving;Cues;Decision Making;disorder risk;Doctor of Philosophy;Dose;drinking;drinking behavior;Drug Metabolic Detoxication;Equilibrium;experimental study;Family history of;follow-up;Genes;glutamatergic signaling;Glutamates;Goals;Human;Impulsivity;innovation;Intoxication;kinase inhibitor;Knowledge;Learning;Link;Memantine;Modeling;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Naltrexone;neurochemistry;neuropsychiatry;novel;novel therapeutics;Opioid;Oral;Participant;Pathway interactions;Pharmaceutical Preparations;Phosphotransferases;Pilot Projects;Placebos;polygenic risk score;Population;pre-clinical;Psychological reinforcement;Randomized;receptor;Relapse;Rewards;Role;Safety;Sarin;Self Administration;sex;Signal Transduction;Smell Perception;social;System;Testing;Therapeutic Agents;therapy development;tool;translational neuroscience;Up-Regulation;Variant

PROJECT_TITLE: Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers