ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Public Health Relevance In this renewal application we propose the continued development of the Drug Dependence Epidemiology Training (DDET), a program to support pre- and post-doctoral training in substance use and substance use disorders. Our goal is to increase the number and quality of health professionals who apply expertise in epidemiology, biostatistics, prevention science, and services research to substance use research use research. We have a demonstrated commitment to enhancing diversity within the drug research community, as well as special emphasis in training on: HIV and Hepatitis C, epidemiological and statistical methods, social and structural factors, psychiatric disorders, and emerging issues, such as overdose prevention and SARS-CoV-2.

PI_NAMEs: JOHNSON, RENEE M.;MAHER, BRION S (contact)

PROGRAM_OFFICER_NAME: LOPEZ, MARSHA

PROJECT_TERMS: Epidemiology;National Institute of Drug Abuse;Training Programs

PROJECT_TITLE: NIDA Epidemiology Training Program


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The goal of this work is to understand how cells govern the architecture and assembly dynamics of cortical actin networks that control cell shape, cell polarization, cell division and tissue morphogenesis. To achieve this, we will use a powerful combination of in vitro reconstitution assays and quantitative microscopy.

PI_NAMEs: KOVAR, DAVID R;MUNRO, EDWIN MARSHALL (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;anillin;Architecture;Biological Assay;biophysical analysis;Caenorhabditis elegans;cell cortex;Cell division;Cell membrane;cell motility;Cell Shape;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cofilin;Coupling;crosslink;Crosslinker;Embryo;Equilibrium;experience;F-Actin;Feedback;Filament;Genes;Genetic;Goals;In Vitro;in vivo;Length;Mediating;Microfilaments;Microscopy;molecular imaging;Morphogenesis;Motility;Motor;Myosin ATPase;Myosin Type II;network architecture;non-muscle myosin;particle;plastin;polarized cell;polymerization;Polymers;profilin;Property;Proteins;Quantitative Microscopy;reconstitution;Regulation;Resolution;RNA Interference;single molecule;Tissues;Work

PROJECT_TITLE: Dynamic control of actin network architecture in early C. elegans embryos

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Neurodegenerative

ORG_CITY: AUSTIN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: NARRATIVE We expect this work to provide new insight into the cellular regulation of protein translation by eEF2K and provide critical advancement in understanding various eEF2K-driven pathologies.

PI_NAMEs: DALBY, KEVIN N (contact);GHOSE, RANAJEET

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Affect;Automobile Driving;Binding;Calmodulin;cell growth regulation;Chronic;Clinical Treatment;Divalent Cations;Elements;Goals;innovation;insight;Kinetics;Length;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular Conformation;Neurodegenerative Disorders;Neurologic;novel therapeutic intervention;Nutrient;Pathology;Post-Translational Protein Processing;Property;Proteins;Regulation;Research;Role;sensor;Signal Transduction;Techniques;Testing;Therapeutic;Translations;Work

PROJECT_TITLE: Regulation of eEF-2K an Energy and Nutrient Sensor


ADMINISTERING_IC: IP

IC_NAME: NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Respiratory viruses, like SARS-CoV-2 and RSV, can cause major problems in society by making people sick and causing death, especially in older people, babies, and those with weakened immune systems. The proposed work will provide critical information on who these viruses affect, how quickly they spread in communities and in households, and how well we are protected by vaccines and previous infections. This information will better inform how to protect people from getting sick, and allow us to respond quickly and effectively to new outbreaks.

PI_NAMEs: CHU, HELEN YING-HUI (contact)

PROJECT_TITLE: IP24-045, SEAPREP:  Seattle Pandemic Preparedness Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZIP1 GCA (63)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: PASADENA

ORG_DEPT: CHEMISTRY

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: Project Narrative Accurate protein biogenesis is a pre-requisite for the generation and maintenance of a functional proteome, and is critical for preventing the onset of numerous diseases rooted in defective protein homeostasis. The proposed studies will advance our knowledge of the molecular and cellular mechanisms that ensure protein homeostasis within the cell, and contribute to the general understanding of physiology and pathology of eukaryotic cells at a fundamental level.

PI_NAMEs: SHAN, SHU-OU  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TITLE: Supplement: Accurate Molecular Decision Making during Protein Biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative Domesticated foxes, unlike their wild ancestors, respond in a positive, friendly manner towards humans, similar to domesticated dogs, who, unlike their wolf ancestors, are friendly to people. This project studies the genetics of these inherited behaviors in order to understand the causes and mechanisms involved and to potentially gain broader insight into a range of human neurological disorders that are characterized by impaired social reciprocity or by anxiety-related and/or aggressive behaviors.

PI_NAMEs: KUKEKOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Aggressive behavior;Animal Model;Anxiety;anxiety-like behavior;Behavior;Behavioral;Canis familiaris;Complex;Development;Disease;disorder risk;foxes;Friends;General Population;Genes;Genetic;genetic information;Genetic study;Goals;Growth;Human;Impairment;Inherited;insight;Mental disorders;Molecular;Nervous System Disorder;novel;Pathway interactions;Persons;Phenotype;Population;Rodent;segregation;Severities;Social Behavior;Social Behavior Disorders;Social Facilitation;social influence;social reciprocity;Symptoms;Variant;Vulpes;wolves

PROJECT_TITLE: Molecular Mechanisms of Social Behavior

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

PHR: Project Narrative of Parent Award This study will uncover fundamental molecular mechanisms that regulate neural circuit development through interactions between cell surface proteins. Although our work is conducted in Drosophila, there is a subfamily of human proteins that corresponds to the Dprs and DIPs, called the IgLONs, which are important for neural circuit formation and have been linked to autism, schizophrenia, and dyslexia. By establishing how these proteins instruct precise neural circuit development, our work will build a foundation for clinical approaches to treat these debilitating diseases.

PI_NAMEs: CARRILLO, ROBERT ARNULFO (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Affinity;autism spectrum disorder;Axon;Binding Proteins;Cell Communication;Cell Surface Proteins;Cells;Clinical;Code;Collaborations;combinatorial;Cues;Data;Development;Developmental Process;Disease;Drosophila genus;Dyslexia;Family;Foundations;Genetic;genetic approach;genetic manipulation;Human;Immunoglobulins;insight;Link;Modeling;Molecular;Morphology;Motor Neurons;Muscle;neural;neural circuit;neuromuscular;neuromuscular system;novel;parent project;Pattern;Positioning Attribute;Presynaptic Terminals;Process;programs;Property;Proteins;Reagent;Role;Schizophrenia;Signal Pathway;Specific qualifier value;Specificity;Stereotyping;Structure;Synapses;synaptic function;Variant;Work

PROJECT_TITLE: IgSF protein interactions drive specificity in circuit wiring and synaptic elaboration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Dietary Supplements;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Networking and Information Technology R&D (NITRD);Nutrition

ORG_CITY: BERKELEY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE - R35 PARENT GRANT The gut microbiota plays a role in protecting humans from disease, digesting food, and shaping immune system function. This project will investigate bacterial mechanisms that control why microbial community composition differs from one individual to another. A deeper understanding of these genes and pathways will inform design of personalized probiotics to treat diseases where the gut microbiota is perturbed.

PI_NAMEs: WOLF, ASHLEY ROBIN (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Actinobacteria class;Area;Atherosclerosis;Bacteria;bacterial metabolism;Bacteroides;Bacteroides thetaiotaomicron;Bacteroidetes;Binding;bioinformatics pipeline;Biology;Biomedical Research;Carbon;career;career development;career preparation;Catabolism;Chronic;cluster computing;Collection;Communities;Complement;Complex;Computational Biology;Computer Analysis;computer program;Consumption;Correlative Study;Degradation Pathway;design;Development Plans;Diet;dietary;Disadvantaged;Disease;dysbiosis;Educational workshop;Environment;Enzymes;Escherichia coli;Evolution;Exclusion;experience;Faculty;Food;Funding;Gene Expression;Genes;Genome;genome sequencing;Genomics;Goals;graduate school preparation;Grant;Growth;gut bacteria;gut health;gut microbiome;gut microbiota;Habitats;Heterogeneity;High Performance Computing;Human;human disease;immune system function;Individual;Industry;interest;Intestines;job market;knockout gene;Knowledge;Laboratories;Learning;Link;Lipids;Measures;Meat;Mediating;member;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;microbial;microbial community;microbiome;microbiota;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;Nutrient;Nutrient availability;Orthologous Gene;parent grant;Pathway interactions;Phenotype;Phylogenetic Analysis;Polysaccharides;poor health outcome;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Probiotics;Process;Production;Publishing;Regulation;Regulatory Pathway;Repression;Research;Research Support;Role;Shapes;Shigella;Shigella flexneri;Sialic Acids;single-cell RNA sequencing;Source;Specificity;Students;supportive environment;symposium;Testing;Therapeutic;Time;tool;Training;Type III Secretion System Pathway;undergraduate student;Virulence;whole genome;Work;Writing

PROJECT_TITLE: Regulation of carbon utilization in gut-resident bacteria


ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative from the Parent Award Stresses such as increased heat and oxidation cause condensation of protein and RNA into aggregates which drive a universally conserved response. Following our recent discoveries that these aggregates, long thought to be toxic, are instead often adaptive, we are pursuing an understanding of the novel functions and regulation of these adaptive condensates in the response to heat shock. We use integrated methods, from biochemistry to cell biology, to understand these phenomena in molecular detail, continuing our longstanding work in a budding yeast model and extending our efforts to understand physiological temperature-dependent responses in the immune system during fever.

PI_NAMEs: DRUMMOND, DAVID ALLAN (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Area;Biochemical;Biochemistry;Biological;Cell Physiology;Cells;Cellular biology;Esthesia;Eukaryotic Cell;Fever;fungus;Growth;Heat shock proteins;Heat-Shock Response;immune activation;Immune system;insight;Link;Messenger RNA;Methods;Modeling;Molecular;Molecular Chaperones;Neurodegenerative Disorders;novel;operation;oxidation;parent project;Physical condensation;Physiological;Process;Proteins;proteotoxicity;Regulation;response;RNA;Saccharomycetales;Signal Transduction;Specificity;Stress;Temperature;Work;Yeast Model System

PROJECT_TITLE: Function and Regulation of Stress-Induced Adaptive Condensates


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Relevance to Public Health The identification, recruitment, selection, and mentorship of scientists from diverse backgrounds to conduct research on Alzheimer’s Disease and Related Dementias (ADRD) (i.e., AD-RCMAR Scientists) and to launch their independent research careers will enhance the diversity of the aging research workforce. The work of the AD-RCMR Scientists and the San Diego Alzheimer’s Disease Resource Center for Minority Aging Research will promote critical advances in our understanding and ability to target multilevel factors and interventions to address ADRD inequities among Hispanics/Latinos, limited English proficient (LEP) and refugee communities.

PI_NAMEs: ELDER, JOHN P.;GILBERT, PAUL E;MOORE, ALISON AHERN (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;behavioral and social science;Biological;brain health;California;career;career development;Career Mobility;Climate;Clinical;Cognitive aging;Collaborations;Collection;Communication;Communities;community collaboration;community engaged research;community partners;County;Data;Data Analyses;Discipline;Disparity;Education;education research;Elderly;Engineering;equity, diversity, and inclusion;experience;Faculty;Fostering;Geriatrics;Gerontology;Health Disparities Research;health inequalities;Hispanic;Hispanic Populations;Hispanic-serving Institution;Home;Individual;Inequity;Infrastructure;Institution;Interdisciplinary Study;Intervention;Investigation;Knowledge;Latino;Latino Population;Leadership;Life Cycle Stages;Limited English Proficiency;Linguistics;Measurement;Measures;Medicine;member;Mentors;Mentorship;Mexico;Minority;Minority Groups;Minority Health Research;novel;older adult;Palliative Care;Pharmacologic Substance;Population;Population Heterogeneity;Positioning Attribute;Principal Investigator;programs;Psychology;Psychometrics;Public Health;Recording of previous events;recruit;Refugees;Research;Research Design;Research Methodology;Research Personnel;Resources;Risk Factors;Science;Scientist;skills;social culture;social science research;Source;success;Targeted Research;Techniques;Time;Training;Training and Infrastructure;training opportunity;Training Programs;Trust;Underrepresented Populations;underserved community;Universities;Work

PROJECT_TITLE: San Diego Alzheimer's Disease Resource Center for Minority Aging Research DEIA Mentorship Supplement


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_DEPT: PSYCHIATRY

PHR: Contact PD/PI: Zhou, Xianjin Project Narrative Glutamate excitotoxicity contributes to the pathogenesis of many different psychiatric disorders and is the primary mechanism for neuronal injury in neurological diseases. Currently, there is no medicine that can suppress glutamate excitotoxicity without inhibiting cognitive functions. Success of this application will open up a new avenue for the development of therapeutic long-lasting autoantibodies that specifically suppress glutamate excitotoxicity and enhance cognitive functions in many neurological diseases and psychiatric disorders including TBI, PTSD, and schizophrenia. Project Narrative Page 7

PI_NAMEs: RISBROUGH, VICTORIA B;ZHOU, XIANJIN  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Antibodies;associated symptom;Autoantibodies;Back;Binding;Blood;Blood - brain barrier anatomy;Brain;Chronic;Cognition;Cognitive;cognitive enhancement;cognitive function;Development;Diameter;Electron Microscopy;Encephalitis;excitotoxicity;Exhibits;Glutamates;Human;IgG autoantibodies;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Impairment;Letters;Marines;Mediating;Medicine;Memory impairment;Mental disorders;Mus;Nervous System Disorder;Neurologic Symptoms;Neuronal Injury;neuronal survival;Neurons;neuroprotection;neurotransmission;NMDA receptor A1;Pathogenesis;Patients;Performance;Plasma;Population;Post-Traumatic Stress Disorders;psychiatric symptom;Psychoses;Reaction Time;Reporting;Schizophrenia;Short-Term Memory;success;Synapses;Synaptic Cleft;Testing;therapeutic development;Width

PROJECT_TITLE: Effects of Different Isotypes of Anti-NMDAR1 Autoantibodies on Cognitive Function and Neuroprotection


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative Misregulation of chromatin states either via misregulation of ATP-dependent chromatin remodeling enzymes or misregulation of heterochromatin is strongly associated with cancer and developmental defects. Yet how chromatin remodeling enzymes work or how heterochromatin is assembled and regulated is poorly understood. This proposal combines biophysical approaches with cellular tests to tackle these challenging questions, with the goal of identifying key steps that are targets for regulation and that can be controlled for therapeutic intervention in the future.

PI_NAMEs: NARLIKAR, GEETA J (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TITLE: Measuring the lifetime and mechanical stability of phase-separated heterochromatin domains


PHR: NARRATIVE Transporters in the kidney play important roles in the elimination of drugs, nutrients, and hormones. SLC22A24, a transporter, has been shown to transport drugs and hormones across cell membranes. In this study, we will discover its role in the kidney of mice and healthy volunteers; our studies will lead to a new understanding of the role of SLC22A24 in human biology and drug response.

PI_NAMEs: GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: absorption;Alleles;analytical method;apical membrane;basolateral membrane;Biological;Biological Assay;Biology;Blood;Cell Line;Cell membrane;Cells;Cellular Assay;clinical phenotype;Computer Analysis;Confocal Microscopy;CRISPR/Cas technology;design;drug disposition;Drug Kinetics;Drug Prescriptions;Drug Transport;Equipment;Evaluation;Excision;Exhibits;Expression Profiling;Family;Gene Frequency;genetic association;Genetic Polymorphism;genome-wide;Genomics;Glucuronides;Goals;healthy volunteer;Homology Modeling;Hormones;Human;Human Biology;In Vitro;Individual;Isotopes;Kidney;Knock-in;Laboratories;Ligands;liquid chromatography mass spectrometry;Liquid substance;Measures;member;Membrane Transport Proteins;metabolomics;Methods;Methotrexate;mouse model;Mus;novel;Nutrient;Organic Anion Transporters;Orphan;Orthologous Gene;Participant;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;Physiology;Plasma;Play;polarized cell;Population;preference;Proteins;Proximal Kidney Tubules;Renal clearance function;Research;response;Role;Signal Transduction;solute;stable cell line;steroid hormone;Steroids;Sulfate;Testing;Therapeutic;Transgenic Mice;uptake;urinary;Variant;Xenobiotics

PROJECT_TITLE: Equipment Supplement NOT-GM-24-021

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Genome instability, which is associated with multiple human diseases, is a byproduct of mutations that accumulate in the human genome as a result of the error prone DNA copying translesion synthesis (TLS) enzymes. Recent publications and strong preliminary work from my lab have shown that the TLS REV1 polymerase regulates metabolic pathways, mitotic fidelity, and replication stress, all of which are known to be associated with genome instability. This proposal will determine the molecular mechanisms by which REV1 controls these non-TLS functions and their potential roles in genome instability.

PI_NAMEs: CHATTERJEE, NIMRAT  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Administrative Supplement;Autophagocytosis;Biological;Black Box;Bypass;Cell Death;Cell Physiology;Communicable Diseases;Data;Dimensions;Disease Progression;disorder control;DNA;DNA biosynthesis;DNA Damage;DNA Sequence Alteration;Enzymes;Exercise;Genome Components;Genomic Instability;Goals;human disease;Human Genome;insight;Laboratories;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Mitosis;Mitotic;Modeling;Modification;Molecular;Mutagenesis;Mutation;Neurodegenerative Disorders;novel;novel therapeutics;Onset of illness;Other Genetics;Pathway interactions;Polymerase;Process;Proteins;Publications;replication stress;response;Role;senescence;tool;Translating;Work

PROJECT_TITLE: Administrative supplement: Mechanistic insights into translesion synthesis-dependent genome instability


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Proper control over the cell cycle is essential to development, homeostasis, and regeneration. The regulation of differentiation and the specification of cell fates has been extensively studied, as have the fundamental mechanisms of cell cycle control, but ubiquitous correlations observed between cell fate and the cell cycle have not been studied in detail. To understand how cell fate regulates the duration of the cell cycle and how changes in the duration of the cell cycle influence cell fate, we will employ a combination of cell lineage tracing, spatial transcriptomics, and an evolutionary approach to studying the structure of developmental lineages.

PI_NAMEs: SHAH, PAVAK KIRIT (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: 3-Dimensional;Animals;Atlases;Biological Models;Caenorhabditis elegans;Cell Culture Techniques;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Fate Control;cell fate specification;Cell Lineage;cell transformation;Cells;Collaborations;deep learning;Dependence;design;Development;Developmental Process;Disease;Embryo;Equipment;Evolution;Exhibits;gene network;Gene Transfer Techniques;Genetic;Homeostasis;Human;Image;In Vitro;Individual;insight;Label;Link;Malignant Neoplasms;Microscopy;Modeling;Molecular;Molecular Analysis;mutant;Natural regeneration;Nematoda;novel strategies;Pattern;programs;reconstruction;Recording of previous events;Regulation;Resources;Same-sex;Somatic Cell;stem cells;Stereotyping;Structure;Study models;Techniques;Technology;Tissues;tool;transcriptomics;Work

PROJECT_TITLE: Lineage-Specific Mechanisms of Cell Cycle Timing Control


NIH_SPENDING_CATS: Biotechnology

PHR: See Research Strategy Section for Project Narrative.

PI_NAMEs: KORTEMME, TANJA  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Equipment;Funding;parent project;Protein Engineering;protein function;Research

PROJECT_TITLE: Equipment Supplement - Computational design of proteins and protein functions

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: Pesticides, fungicides and insecticides are established risk-factors for neuronal injury and neurodegenerative onset. Here, we develop and test whether Carbon Quantum Dots (CQDs), which are nano materials synthesized from bio-waste precursors such as fruit peel, lignin, used frying oil and recycled paper, can restore cellular and organismal deficits induced by pesticide exposure. The proposed microscopy imaging work is important because, if successful, it advances a mechanistic understanding of how CQDs can exert their neuroprotective effects in vitro and in vivo by mitigating pesticide-associated neurodegenerative disorders.

PI_NAMEs: NARAYAN, MAHESH  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Ablation;Acids;alpha synuclein;Amyloid;Amyloid Proteins;Architecture;Behavioral;behavioral outcome;Biological Availability;Caenorhabditis elegans;Carbon;cell behavior;Cell Line;Cell model;Cells;Color;confocal imaging;Confocal Microscopy;Data;Development;Dopaminergic Cell;Exposure to;Fluorescence;fluorescence imaging;Free Radicals;Fruit;fungicide;Herbicides;Homeostasis;In Vitro;in vivo;Insecticides;insight;Knowledge;Lignin;Link;microscopic imaging;Modeling;nanomaterials;nanoscale;Nematoda;Nerve Degeneration;Nervous System;Neurodegenerative Disorders;neuron development;neuron loss;Neuronal Injury;Neurons;neuroprotection;neurotoxicity;Neurotoxins;novel;Oils;Organism;Outcome;Paper;Paraquat;parent grant;pesticide exposure;Pesticides;Physiological;prevent;Prevention;protein aggregation;Proteins;Quantum Dots;Recycling;Risk Factors;Role;Stress;Testing;Tissues;Toxic effect;Toxic Environmental Substances;toxicant;Transgenic Organisms;Work;Xenobiotics

PROJECT_TITLE: Development and testing of Carbon Quantum Dot architectures to arrest neurotoxicant-insult- related outcomes


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Fear and anxiety underlie the most common forms of mental illness in the United States, with more than 30% of Americans experiencing an emotional disorder at some point in their life. Consequently, a major goal of NIH is to understand the neural mechanisms that underlie adaptive and maladaptive threat processing. The hippocampus and dopamine release (via the locus coeruleus and ventral tegmental area) both contribute to fear and anxiety, but it is not known how they interact during these states to promote the encoding of aversive memories. This represents a major gap in our understanding of the neural systems that contribute to emotional disorders. Altered catecholamine release accompanies schizophrenia, bipolar disorder, and ADHD, which are often comorbid with fear and anxiety disorders. Alzheimer’s disease also produces severe atrophy of the locus coeruleus, which reduces catecholamine release throughout the brain and is thought to exacerbate amnesia. To determine how altered catecholamine levels impact these disorders, it is essential to establish the basic mechanisms by which neuromodulatory inputs to the hippocampus regulate the formation of aversive memories.

PI_NAMEs: WILTGEN, BRIAN J (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Alzheimer's Disease;American;Amnesia;Animals;antagonist;Anxiety;Anxiety Disorders;Atrophic;Attention deficit hyperactivity disorder;Aversive Stimulus;Behavioral Assay;Binding;Bipolar Disorder;Brain;Brain region;Calcium;Catecholamines;comorbidity;conditioned fear;Data;designer receptors exclusively activated by designer drugs;Disease;Dopamine;Dopamine D2 Receptor;dopaminergic neuron;Dorsal;Emotional disorder;emotional experience;eticlopride;Event;experience;experimental study;Fiber;Fluorescence;Fright;Funding;Future;Goals;graduate student;Hippocampus;Hour;Human;Image;Impairment;Implant;in vivo;Injections;Learning;Lesion;Life;locus ceruleus structure;long term memory;Measures;Memory;memory consolidation;Memory impairment;memory process;Mental disorders;Monitor;Mus;Neocortex;neural;neuromechanism;Neuromodulator Receptors;Neurons;neuroregulation;Neurosciences;Norepinephrine;novel;optical fiber;optogenetics;parent grant;Parents;Photometry;Play;Population;prevent;promoter;psychologic;rehearsal;Research Project Grants;Role;Schizophrenia;selective expression;sensor;Signal Transduction;Site;Source;Stimulus;Synaptic plasticity;System;Techniques;Testing;Time;Training;United States;United States National Institutes of Health;Ventral Tegmental Area;Vertebral column;Work

PROJECT_TITLE: The role of novelty and surprise in aversive learning


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: The results of this translational study will provide the first evidence that a targeted intervention with an anti- inflammatory medication can reverse both the underlying pathology and depressive state in “inflammatory depression” in rodents and humans. As such, our findings will be of direct benefit to MDD patients by providing alternative, targeted treatment options, so as to improve poor remission rates currently associated with use of monoaminergic antidepressants.

PI_NAMEs: DELORENZO, CHRISTINE ;PARSEY, RAMIN V. (contact)

PROGRAM_OFFICER_NAME: LAWHORN, COLLENE

PROJECT_TERMS: Accounting;Affect;Affinity;Aftercare;anti-depressive agents;Anti-Inflammatory Agents;antidepressant effect;Astrocytes;biological heterogeneity;Brain;celecoxib;Chronic;Clinical;Clinical Trials;clinically relevant;cohort;Data;density;Depressed mood;depression model;depressive symptoms;design;Disease;Disease remission;disorder subtype;Enrollment;Evaluation;Exclusion;Exhibits;Functional disorder;Genetic Polymorphism;Genotype;Health;healthy volunteer;Heterogeneity;Human;Image;improved;in vivo;Individual;Inflammatory;inflammatory marker;insight;Intervention;Major Depressive Disorder;Measures;Medicine;Mental Depression;Messenger RNA;Microglia;microPET;Modeling;Molecular;Morphology;mouse model;Mus;Neuroglia;neuroinflammation;novel;optimal treatments;Outcome;Outer Mitochondrial Membrane;Participant;Pathology;Patient Recruitments;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;Population;Positron-Emission Tomography;Prefrontal Cortex;prevent;protein expression;Proteins;Proxy;Psychiatry;Reporting;response;Rodent;Selective Serotonin Reuptake Inhibitor;Severities;Signal Transduction;single episode major depressive disorder;social defeat;Stress;Subgroup;targeted treatment;Testing;Text;translational study;Treatment outcome;treatment strategy;volunteer;Wild Type Mouse

PROJECT_TITLE: A translational study of neuroinflammatory depression: Understanding mechanism and evaluation of a novel pharmacologic intervention


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_DEPT: BIOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative When a taste is placed on our tongues, we must recognize that a taste is on the tongue, identify that taste, decide whether it’s palatable or not, and then either swallow it or expel it. These processes require integration of information about taste from the periphery, which is relayed to the taste cortex, in part through the gustatory thalamus, though it is unclear how thalamus and gustatory cortex interact to produce activity in gustatory cortex that reflects stimulus identity and palatability, which we will study here. These results will increase our understanding of taste that will help us fight against a spectrum of feeding-related disorders.

PI_NAMEs: KATZ, DONALD B;VAN HOOSER, STEPHEN D (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Thalmocortical interactions in taste perception

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


NIH_SPENDING_CATS: Bioengineering;Genetics;Microbiome

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Project Narrative Even genetically identical bacteria may activate different subsets of genes leading to coexistence of diverse metabolic states and behaviors within a bacterial population. In this work, we will develop and apply high-throughput single-cell transcriptomics approaches to profile heterogeneous phenotypic states within complex bacterial communities such as spatially structured biofilms and reduced complexity microbiota. We will use the results to develop systems-level understanding of the fine-scale phenotypic structure and pave the way toward predicting the emergent properties of biofilms and natural microbiota.

PI_NAMEs: KUCHINA, ANNA  (contact)

PROJECT_TERMS: Bacteria;bacterial community;Behavior;Behavioral;biofilm species;biological adaptation to stress;Biological Assay;biological research;cell behavior;Cells;Communities;Complex;Cues;Data;Development;Ecology;Engineering;Environment;Foundations;Gene Expression;gene regulatory network;Genes;gut microbiota;Horizontal Gene Transfer;Human;Image;Individual;laboratory equipment;Ligation;Maps;Measurement;Measures;member;Metabolic;microbial;Microbial Biofilms;microbial community;Microbiology;microbiome research;microbiota;Nature;network models;Organism;Pathway interactions;Phenotype;Play;Population;Postdoctoral Fellow;programs;Property;Pseudomonas aeruginosa;Reporter;Resolution;response;Role;Sampling;single-cell RNA sequencing;Staphylococcus aureus;Structure;System;Technology;Testing;tool;trait;transcriptomics;Work

PROJECT_TITLE: Single-cell transcriptomics of complex bacterial communities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This proposal is a diversity supplement in line with the goals of the NIH to increase diversity in STEM research. This work seeks to better understand the mechanisms by which the brain learns new movement. This new insight will be critical to developing better recovery treatments for people with brain-related movement disorders.

PI_NAMEs: LINDERMAN, SCOTT WARREN;NUYUJUKIAN, PAUL  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Automobile Driving;awake;Behavior;Behavioral;Biological Models;Brain;brain control;Brain Diseases;brain machine interface;Brain region;Central Nervous System;Chronic;cohort;Communities;Complex;computational neuroscience;Coupled;Creativeness;Data;Data Set;Development;Dimensions;dynamic system;Educational process of instructing;Electrophysiology (science);Exertion;Goals;Head;high dimensionality;Image;improved;insight;Investigation;Joints;kinematics;Knowledge;Learning;Limb structure;Literature;Maps;markov model;Measurement;Measures;Methods;Mission;Modeling;Monitor;Motor;motor behavior;motor control;Motor Cortex;motor deficit;Motor disability;motor learning;Motor Neurons;motor recovery;Movement;Movement Disorders;multi-electrode arrays;neural;Neurons;Neurosciences;next generation;nonhuman primate;novel;operation;Parkinson Disease;Performance;Persons;Phase;Physical activity;Population;programs;rate of change;Recovery;Recurrence;repository;Research;Research Proposals;restraint;Standard Model;Standardization;STEM research;Stroke;Synaptic Transmission;System;Time;United States National Institutes of Health;Update;Walking;wireless transmission;Work

PROJECT_TITLE: CRCNS: Deconstructing ... - Diversity Research Supplement - Michael Silverangel

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE Tenuous housing relationships with landlords/property managers can increase feelings among tenants that they must move, resulting in a group of tenants to move (i.e. soft displacement), while another group of tenants stay yet continue to feel the pressure that they must move (i.e. potential displacement). Less is known about these two groups of marginalized renters since there is no court ordered eviction notice attached to their displacement; however, data from the parent award and new data gained through qualitative interviews provide the opportunity to do an in-depth investigation of how (soft vs. potential) displacement, economic hardships, psychosocial stressors, and other decision-making processes contribute to mental health disparities. The supplement also provides the opportunity to support two first-generation college graduates to strengthen their research skills and serve as role models for first-generation college students.

PI_NAMEs: HERNANDEZ, DAPHNE C. (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Adult;Affect;Anxiety;Applied Research;Back;Behavioral Research;Black Populations;career;Child;college;Communities;cost;court;COVID-19;Data;Decision Making;design;Development;disability;Discrimination;Diverse Workforce;diversity and inclusion;Economics;Exhibits;experience;Family Relationship;Feeling;Feeling suicidal;Female;First Generation College Students;Focus Groups;Food;Food Assistance Programs;food insecurity;Funding;Gender Identity;Generations;Goals;Grant;Health;Health Disparities Research;health disparity;Hispanic Populations;Homelessness;Household;Housing;Hunger;improved;Interview;Investigation;Latina;Leadership;marginalized population;Mental Depression;Mental Health;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Nature;Outcome;pandemic disease;parent project;Photography;Policies;Postdoctoral Fellow;pressure;Process;Professional Organizations;programs;Property;psychosocial;Psychosocial Stress;psychosocial stressors;Publications;Race;recruit;Research;research study;Risk;Role;role model;School Nursing;Self Efficacy;Self-reflection;Series;Shelter facility;skills;social determinants;Social Work;structural health determinants;Students;Surveys;symposium;System;Texas;therapy design;Time;Training;Training Programs;Transportation;undergraduate student;webinar

PROJECT_TITLE: Invisible Evictions: Displacement Pressures and Mental Health


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: A hallmark feature of many neurodegenerative diseases is an inability of neurons to meet their cellular homeostasis demands due to hindered autophagy activity. I hypothesize that neurons employ an alternate pathway, autophagy-dependent secretion, to offload damaged proteins and dysfunctional organelles when faced with an overwhelmed autophagy system. I propose to define the interplay between autophagy and secretion when neurons are stressed (Aim 1), and to challenge the hypothesis that neurons offload mitochondria for transcellular internalization (Aim 2).

PI_NAMEs: PALUMBOS, SIERRA DANIELLE (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;acute stress;Aging;Astrocytes;Autophagocytosis;Autophagosome;Cell Separation;cell type;Cells;Cellular Stress;Chronic;Chronic stress;Coculture Techniques;Complement;CRISPR interference;Data;Dementia;design;Disease;Disease Progression;disease-causing mutation;DNA;Electron Microscopy;Equilibrium;experimental study;extracellular vesicles;Frequencies;Functional disorder;Health;high resolution imaging;Homeostasis;Hyperactivity;Impairment;In Vitro;in vivo;insight;interest;knock-down;Link;LRRK2 gene;Magnetism;Mediating;Metabolic;Microscopy;Mitochondria;mitochondrial autophagy;Mitochondrial Proteins;Modeling;Molecular Profiling;Motor;mutant;Mutant Strains Mice;Nature;Neurodegenerative Disorders;Neuroglia;neuron loss;Neuronal Dysfunction;Neurons;Organelles;Parkin;Parkinson Disease;Pathway interactions;Phosphotransferases;PINK1 gene;postmitotic;protein aggregation;Proteins;Proteomics;proteostasis;Quality Control;Resolution;Role;Route;Shunt Device;Stress;Stress and Coping;superresolution microscopy;System;systemic inflammatory response;Testing;Transgenic Mice;Up-Regulation;Visualization;wasting;Western Blotting

PROJECT_TITLE: Interplay between macroautophagy and secretory autophagy in neurons.

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PI_NAMEs: HOUSE, SAMANTHA A. (contact);WONG, SANDRA L

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Accident and Emergency department;care delivery;Caring;Child;Child Mortality;Childhood;cost;Data;Deimplementation;Disparity;Environment;Health;health care delivery;health care service utilization;Health Information System;Healthcare;hospital care;Hospitals;imaging study;Inpatients;Literature;Measures;Medicaid;Methodology;Outcome;Patients;Pediatric Hospitals;peer;poor health outcome;Prevalence;Qualitative Methods;Research;Research Priority;Rural;rural area;rural disparities;Rural Health Centers;Rural Hospitals;Science;Services;System;tool;United States;urban area;Visit;wasting

PROJECT_TITLE: Measuring pediatric hospital-based low-value care: Urban-rural disparities and associated downstream healthcare utilization


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Health Services;Lung;Patient Safety;Prevention;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: PAULIN, LAURA MARIE (contact);WONG, SANDRA L

PROJECT_TERMS: Address;adverse outcome;Air Pollution;Belief;Cessation of life;Characteristics;Chronic Obstructive Pulmonary Disease;Cigarette;cigarette smoking;Clinical;Communities;Development;Disease Progression;Economic Factors;Environmental Exposure;Environmental Risk Factor;Focus Groups;Future;Goals;Health;health care delivery;Health Knowledge Attitudes Practice;Heating;Home;improved;improved outcome;Individual;indoor concentrations;indoor particulate matter;Inhalation Exposure;Intervention;Interview;Morbidity - disease rate;New England;Outcome;Particulate Matter;Patients;Perception;Pollution;poor health outcome;Population;Prevalence;recruit;Research;respiratory;respiratory morbidity;Risk;risk perception;Rural;rural area;rural dwellers;Rural Health;Rural Health Centers;Science;social factors;social influence;solid fuel;Source;Structure;therapy design;Tobacco use;trial design;United States;Wood material

PROJECT_TITLE: COPD and Rural Health: Identifying Environmental Exposures Associated with Adverse Outcomes


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE The proposal “Guiding the Safe and Effective Integration of Ambient Digital Scribes into Primary Care” outlines a clear strategy for swiftly developing a prototype guide to safely and effectively implement ambient digital scribes into their primary care practices, designed to help healthcare provider organizations of all sizes – ranging from large multi-facility healthcare systems to individual clinics and federally qualified health centers. This work will provide novel insight into how this new transformational AI-driven technology will change the workflow of primary care. Given the prevalence of primary care physician burnout and the inevitable ubiquity of this technology, this guide is a timely approach to addressing safety and equity concerns with implementing ambient digital scribes.

PI_NAMEs: BIRO, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Narrative Not Applicable for Supplement Application

PI_NAMEs: SHANK, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: 16S ribosomal RNA sequencing;Administrative Supplement;Agar;Antibiotics;Bacillus;Bacillus subtilis;Bacteria;Behavior;Bioinformatics;Biological;career networking;cell type;Cells;Chemicals;Chemistry;Coculture Techniques;cohort;Coupled;Data Analyses;Data Set;Development;Educational workshop;empowerment;equity, diversity, and inclusion;Exclusion;experimental study;Faculty;Female;Fluorescence-Activated Cell Sorting;Funding;Future;Gene Cluster;Genes;Genetic Transcription;genome sequencing;Goals;graduate student;Heterogeneity;improved;insight;Institution;Knowledge;Lead;Leadership;Liquid Chromatography;Maps;mass spectrometric imaging;Mass Spectrum Analysis;member;Mentors;Mentorship;Metabolic;metabolomics;microbial;Microbial Biofilms;Monitor;multitask;nano-string;outreach program;parent project;Phylogenetic Analysis;Physiology;Production;Productivity;Publishing;Recording of previous events;Research;Research Personnel;Research Project Grants;Science;Services;Signal Transduction;skills;spatial relationship;Structure;symposium;System;Time;Training;Training Activity;transcriptome sequencing;transcriptomics;two-dimensional;Underrepresented Populations;Underserved Population;Visit;whole genome;Work

PROJECT_TITLE: DEIA Mentorship Supplement R35GM145261


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: PITTSBURGH

ORG_NAME: DUQUESNE UNIVERSITY

PHR: Lewy body disorders are associated with the formation of insoluble protein aggregates that may spread from cell to cell, eventually appearing in multiple vulnerable regions of the nervous system. During the intercellular transfer of protein aggregates, innate immune cells residing in the brain may engulf and clear a portion of the aggregates, but this defense mechanism is not sufficient to fully prevent Lewy body disease. To boost this defense, we will determine if engulfment of protein aggregates can be kickstarted with a pharmacologically-induced immune cell depletion and repopulation event.

PI_NAMEs: HU, XIAOMING ;LEAK, REHANA K (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Age Months;alpha synuclein;Amygdaloid structure;Anhedonia;Animal Model;Animals;antagonist;Anterior;Anxiety;Behavior;Biological Availability;Brain;Brain region;Brain Stem;Candidate Disease Gene;Cell Nucleus;cell type;Cells;Central Nervous System;Cessation of life;Clinical;Complex;CSF1 gene;Data;Defense Mechanisms;Dementia;density;Deposition;dietary;Disabling;Disease;disease model;Dopamine;Electron Microscopy;Endocytosis;Endosomes;entorhinal cortex;Event;exhaustion;extracellular;Extracellular Matrix;Family;Genes;Genetic Variation;Goals;Hippocampus;Hour;Housing;Human;Immune;Impairment;improved;in vivo;Inbred Strain;Infusion procedures;inhibitor;Intercellular Fluid;Label;Lewy Body Disease;Lewy body pathology;Macrophage;male;Memory;Memory impairment;Microglia;Modeling;mortality;motor impairment;mouse model;Mus;Nerve Degeneration;nerve supply;Nervous System;Neurons;nigrostriatal pathway;non-motor symptom;olfactory bulb;olfactory nuclei;Oral Administration;Pathology;Patients;Phagocytes;pharmacologic;piriform cortex;Play;Population;Pre-Clinical Model;pre-formed fibril;prevent;Primates;prion-like;Probability;Proliferating;Prosencephalon;protein aggregation;Proteins;Protocols documentation;Rattus;receptor;Rejuvenation;risk variant;Rodent;Role;sex;small hairpin RNA;Smell Perception;Sonication;Sorting;spatial memory;Structure;Synapses;synucleinopathy;Telencephalon;Testing;Therapeutic;transcriptome;transcriptome sequencing;transmission process;Withdrawal;Work

PROJECT_TITLE: Repopulation of the Microglia/Macrophage Niche in Experimental Lewy Body Disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Childhood Leukemia;Digestive Diseases;Hematology;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Ashburn

ORG_NAME: NOVATEUR RESEARCH SOLUTIONS, LLC

ORG_STATE: VA

PHR: ODIN addresses image acquisition, missed diagnosis, and longitudinal monitoring, simplifying the acquisition protocol for trained and untrained individuals. Currently, no such technology exists in the market space for NEC diagnosis.

PI_NAMEs: KUMAR, VIKSIT  (contact)

PROJECT_TITLE: Ultrasound-based Diagnosis and Monitoring of Neutropenic Enterocolitis in Children with Acute Lymphoblastic Leukemia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: The proposed research is relevant to public health because it will advance the toolkit used in discovery science for high yield early phase target validation and therapeutic screening for the development of new treatments for mental health disorders. By understanding how local impairments alter systems-level network function in relation to a clinically relevant cognitive test used for human neuropsychological assessment, it will be possible to promote the development of interventions that improve the health and wellbeing of individuals with mental illness and meet the mission of the NIMH.

PI_NAMEs: BURKE, SARA N;MAURER, ANDREW PORTER (contact)

PROGRAM_OFFICER_NAME: HUPALO, SOFIYA

PROJECT_TERMS: Address;Affect;Affective;analog;Animal Model;Animals;Anxiety;autism spectrum disorder;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Biological Assay;Biological Markers;Bipolar Disorder;Brain;cholinergic;Clinical;Clinical Trials;clinically relevant;Cognition;cognitive function;cognitive process;cognitive testing;Communication;comparative;Coupling;Data;density;design;designer receptors exclusively activated by designer drugs;Development;diagnostic tool;drug discovery;drug efficacy;drug testing;Elderly;Electroencephalography;emotion regulation;Evaluation;experimental study;Failure;Foundations;Funding;Funding Opportunities;Goals;Health;Heart Diseases;high throughput screening;Hippocampus;Human;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;Knowledge;Link;Malignant Neoplasms;Mammals;Measures;mental development;Mental disorders;Mission;Modeling;National Institute of Mental Health;neural;Neurobiology;Neurons;neurophysiology;Neuropsychological Tests;Neuropsychology;Neurotransmitters;novel;novel diagnostics;novel therapeutics;Outcome;Paired-Associate Learning;Parietal;Performance;Personal Satisfaction;pharmacologic;Pharmacologic Substance;Pharmacological Treatment;Phase;Physiological;pre-clinical;predictive marker;Prefrontal Cortex;Psychiatric therapeutic procedure;Psychiatry;Public Health;Research;Rodent;Schizophrenia;Science;screening;Screening procedure;Series;Severities;Severity of illness;Surface;System;Task Performances;Technology;Temporal Lobe;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;touchscreen;Translating;Traumatic Brain Injury;treatment optimization;Validation

PROJECT_TITLE: Preclinical Assays of Hippocampal-Prefrontal Cortical Circuit Engagement for Application in Therapeutic Development

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Alzheimer’s disease is the most common cause of dementia, affecting 6.7 million Americans aged 65 and older, and causing a significant public health crisis. The project aims to develop a translational human-mouse neuronal chimeric brain model for studying tau pathology in Alzheimer’s disease. With this model, we will characterize tau pathology, dissect the relationship between the progression of tau pathology in human neurons and cognitive dysfunction, identify dysregulated cellular pathways in human neurons during the progression of tau pathology, and directly compare tau pathology between human and mouse neurons within the same brain environment.

PI_NAMEs: XU, RANJIE  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Address;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;American;Animal Model;Animals;Autopsy;Behavioral;Brain;brain tissue;Cell Line;Cells;Characteristics;Chimera organism;Clinical Trials;Dementia;Disease;Engraftment;entorhinal cortex;Environment;Exhibits;Face;Fibroblasts;Genes;Genomics;Goals;Hippocampus;hTau Mice;Human;human induced pluripotent stem cells;human old age (65+);Impaired cognition;In Vitro;in vivo;Induced pluripotent stem cell derived human neuron;Injections;innovation;insight;Intervention;Knock-in Mouse;Modeling;Modification;Monitor;Mus;Mutation;Neocortex;neonatal mice;nerve stem cell;Neurofibrillary Tangles;Neuronal Dysfunction;neuronal excitability;Neurons;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Pattern;pre-clinical;Protein Isoforms;Public Health;Research;RNA Splicing;Severities;spatiotemporal;species difference;Study models;targeted treatment;tau aggregation;tau Proteins;Tauopathies;Testing;Therapeutic Intervention;therapeutic target;tool;transcriptomics;Transgenic Mice;translational model;translational therapeutics

PROJECT_TITLE: Develop a human-mouse chimeric brain model for studying tau pathology in human neuron in vivo


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cardiovascular;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: STRATFORD

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Adulteration of the illicit fentanyl supply with xylazine is rapidly spreading across the country. Xylazine reportedly enhances the euphoric effects of fentanyl, but the combination of the two drugs is also associated with increased risk of cardiorespiratory depression and resistance to standard opioid overdose medications. The goal of this research is to identify new treatments that have the potential to block both the desirable and the harmful effects of fentanyl-xylazine mixtures.

PI_NAMEs: MANVICH, DANIEL F. (contact);MARTINEZ, DIANA

PROGRAM_OFFICER_NAME: LE, HOANG VAN

PROJECT_TERMS: Abstinence;Accounting;Adrenergic Agonists;Adrenergic Receptor;Agonist;Analgesics;Animal Model;Animals;antagonist;Anticonvulsants;Blood Pressure;Bradycardia;Cardiovascular Physiology;Case Study;Cessation of life;Chemosensitization;Chronic;Clinical;Country;Development;drug discrimination;Epidemiology;Euphoria;experience;FDA approved;Fentanyl;fentanyl use;Fright;Goals;Government;Health;Heart Rate;Human;Hypotension;Hypoxia;Illicit Drugs;Individual;Intranasal Administration;Measures;Mediating;medical countermeasure;Medical emergency;Mental Depression;mu opioid receptors;Naloxone;Norepinephrine;novel;Opioid;Opioid Antagonist;opioid epidemic;opioid exposure;opioid overdose;Opioid Receptor;opioid user;Overdose;overdose death;Pharmaceutical Preparations;pharmacologic;Physiological;Physiological Processes;Plethysmography;Poison;pre-clinical;preclinical study;Predisposition;presynaptic;prevent;Procedures;Rattus;receptor;Receptor Activation;Receptors, Adrenergic, alpha-2;Reporting;Research;Resistance;Respiration;response;Risk;Sedation procedure;sedative;Series;Stimulus;Surveys;Sympatholytics;synthetic opioid;System;Telemetry;Temperature;Testing;Training;trend;Ventilatory Depression;Whole Body Plethysmography;Work;Xylazine

PROJECT_TITLE: Counteracting cardiorespiratory and subjective effects of fentanyl-xylazine mixtures using a dual antagonist approach

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: VASQUEZ DE CORONADO

ORG_COUNTRY: COSTA RICA

ORG_FIPS: CS

ORG_NAME: INTER-AMERICAN INSTITUTE FOR COOPERATION ON AGRICULTURE -IICA

PHR: Project Narrative: With this new cooperative agreement, we intend to build upon the previous activities to help farms and facilities get an accurate message about the Food Safety Modernization Act (FSMA) regulations and adopt and implement the Rules that pertain to them. The overall goal is to help exporters in Latin America strengthen their food safety programs in order to export safer food and comply with the United States food safety regulations. IICA has the capacity to implement many outreach and innovative capacity building activities relying on its extensive network of professionals trained under current and previous projects related to FSMA and food safety. IICA can find the most appropriate location/users (specific countries/farms, etc.) for any programs and, as appropriate, align with or consider ongoing and planned training by other organizations as part of the context for this proposal. IICA can work and conduct outreach with government, academia, and the private industry. These capabilities have brought success to the previous two cooperative agreements between FDA and IICA. Through this project, we will use innovative and well- tested approaches, new learning techniques, and robust evaluation to ensure sustainable knowledge building and improved understanding around FSMA implementation and compliance. Tracking

PI_NAMEs: CORDERO, ANA MARISA  (contact)

PROGRAM_OFFICER_NAME: MAXIMO, JULIANE

PROJECT_TITLE: Modernizing, Expanding, and Measuring the Impact of FDA Food Safety Initiatives

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 OC-T (06)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: According to NOT-OD-24-001, a project narrative is not applicable.

PI_NAMEs: KESARWALA, APARNA  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Air;Algorithms;Anatomy;Cancer Patient;Cardiac;Cardiotoxicity;Chest;Clinical;cone-beam computed tomography;Coronary artery;Data;Databases;deep learning;Development;Diffusion;Dimensions;Dose;Dose Limiting;early phase clinical trial;Early treatment;Evaluation;Funding;Future;Gender;gender difference;Generations;generative adversarial network;Goals;Heart;Heart Injuries;high risk;Human;Image;imaging Segmentation;improved;Inferior;innovation;Lung;Malignant neoplasm of lung;Maps;member;Methods;Modeling;Modernization;Motion;Non-Small-Cell Lung Carcinoma;novel;Organ;Outcome;parent project;Parents;patient subsets;Patients;Pattern;Phase I Clinical Trials;Physicians;Positioning Attribute;Pre-Clinical Model;prognostic;Race;racial difference;racial population;Radiation;Radiation Oncology;radiation risk;Radiation therapy;rapid technique;Research;Risk;Running;Scanning;Secondary to;simulation;Structure;success;Testing;Time;Tissues;Toxic effect;Training;treatment planning;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Early-Stage Clinical Trial of AI-Driven CBCT-Guided Adaptive Radiotherapy for Lung Cancer

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Genetics;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: CFTR modulators are a novel class of therapeutic compounds, and this research will contribute significantly to the understanding of the metabolism of these compounds in patients with cystic fibrosis to optimize therapy and usher in an era of precision therapeutics. The findings will enhance efficacy of CFTR modulator therapy for all patients with cystic fibrosis and help expand these novel therapies to all patients who might benefit from them. The knowledge gained in metabolism enzyme pharmacogenomics also has important implications for other diseases, including chronic obstructive pulmonary disease, pulmonary infections, and asthma.

PI_NAMEs: GUIMBELLOT, JENNIFER S (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;Affinity;Aftercare;airway epithelium;Alabama;Asthma;autosome;Bicarbonates;Binding;Biological Markers;Body mass index;burden of illness;career;career development;Career Mobility;Caring;Cells;Cessation of life;Childhood;Chlorides;Chronic Obstructive Pulmonary Disease;Clinical Data;Clinical effectiveness;clinical efficacy;Clinical Research;Clinical Trials;Combined Modality Therapy;Complement;Complex;Conduct Clinical Trials;CYP3A4 gene;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Cytochrome P450;Data;Dedications;Defect;Dependence;Development;Disease;DNA;Dose;drug efficacy;Drug Exposure;Drug Kinetics;drug metabolism;Environment;enzyme activity;Enzymes;Epithelial Cells;Epithelium;experience;Exposure to;Faculty;Family;Frequencies;Functional disorder;Future;Genetic;genetic variant;Genetic Variation;Genotype;Goals;Hepatic;Homeostasis;Human;Impairment;In Vitro;Individual;individual patient;Knowledge;Life;Lung;Lung infections;Measurement;Measures;Medical;medical schools;member;Mentors;Metabolism;Methods;Molecular Target;monolayer;Mucous body substance;Mutation;novel;novel therapeutics;Nutritional status;Parents;Patient Care;Patients;pediatric department;Persons;Pharmaceutical Preparations;Pharmacogenetics;Pharmacogenomics;Pharmacologic Substance;Pharmacology;pharmacometrics;Phenotype;Physicians;Pilot Projects;Plasma;Population;Positioning Attribute;Precision therapeutics;Production;Prospective Studies;Protein Isoforms;Proteins;pulmonary function;Pulmonology;Recombinants;recruit;Regulator Genes;Research;response;restoration;Scientist;Single Nucleotide Polymorphism;skills;Spirometry;statistics;success;System;Testing;Therapeutic;Thick;Tissues;Training;treatment optimization;treatment response;Universities;Variant;Viscosity;VX-770

PROJECT_TITLE: Pharmacometric approaches to precision optimization of ivacaftor response in cystic fibrosis patients

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE One of the most important factors causing inter-individual variations in caries susceptibility and high dental caries prevalence worldwide is the host genetics, which influences the tooth anatomy and tooth hard tissue (enamel and dentin) quality. In our interest to understand host susceptibility to efficiently prevent dental caries, the proposed research will provide insights into the molecular mechanisms underlying dental caries risk due to dentin developmental defects caused by deficiency of Trps1 transcription factor in odontoblasts, which also leads to impaired enamel quality. The fundamental understanding of critical pathways controlling crosstalk between odontoblasts/ameloblasts will result in opportunities to achieve precision medicine and improve treatment options for diseases that impact dental hard tissue health, such as dental caries.

PI_NAMEs: SOCORRO, MAIROBYS  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: 3-Dimensional;Acids;Affect;Ameloblasts;Anatomy;Award;Biogenesis;Bioinformatics;bone;Caries prevention;Cell Physiology;cell type;Cells;Chemicals;Child;Chronic;Chronic Disease;Clinical;Code;Communication;Complement;conditional knockout;Critical Pathways;Defect;demineralization;Dental;Dental caries;Dental Caries Susceptibility;Dental Enamel;Dentin;Dentin Formation;Dentinoenamel junction;Dentinogenesis;Dentists;Development;Disease;Down-Regulation;Electron Microscopy;electron tomography;Enamel Formation;Enzymes;Etiology;Experimental Designs;experimental study;follow-up;Foundations;Funding;Future;Gene Expression;Genes;Genetic;genetic risk factor;Genetic study;Genetic Transcription;genome wide association study;Global Change;Grant;Health;Healthcare;Heterozygote;High Prevalence;high risk population;Human Genetics;Immunohistochemistry;impaired driving performance;Impairment;improved;In Situ Hybridization;In Vitro;Incisor;Individual;individualized prevention;insight;inter-individual variation;interest;Knockout Mice;Knowledge;Label;Mandible;Maps;Methodology;mineralization;Molecular;Morphology;Mus;Mutation;nano;nanoscale;Odontoblasts;Online Mendelian Inheritance In Man;Ontology;Outcome;Pathology;Pathway interactions;Patients;permanent tooth;personalized health care;personalized medicine;Physiology;Play;Positioning Attribute;postnatal;precision medicine;Predisposition;Prevalence;prevent;Prevention strategy;Preventive measure;Primary Dentition;Procedures;Process;Proteins;Publishing;Raman Spectrum Analysis;Rare Diseases;Regulation;Research;response;Risk;Risk Assessment;Risk Factors;risk variant;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;structural biology;submicron;Testing;tissue repair;Tissues;Tooth structure;transcription factor;Transcriptional Regulation;Vesicle;WNT Signaling Pathway;X ray microscopy

PROJECT_TITLE: Molecular Signaling in Dentinogenesis and Dental Caries Risk

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: KINGSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE This administrative supplement will expand the URI ESTEEMED program by (1) increasing the size of the annual student cohort augment training activities and (2) strengthening mentor training through the creation of a formal Inclusive Mentor Training Program at URI. The increased cohort size will directly improve trainee outcomes through improved peer-to-peer networking, additional opportunities for near-peer mentoring, and supplemental academic support, while the Inclusive Mentor Training Program will provide sustainable and intensive mentor training with a targeted focus on supporting trainees from diverse and underrepresented backgrounds. With these additional resources, URI ESTEEMED will develop and train a diverse cohort of students with the technical and soft skills necessary to excel in advanced research programs in bioengineering and related fields.

PI_NAMEs: MEENACH, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Academic support;Administrative Supplement;Awareness;Biomedical Engineering;Calendar;cohort;Collaborations;college;Development;Discipline;Education;Educational Curriculum;Environment;experience;Faculty;faculty mentor;Goals;graduate student;Human Resources;improved;Mentors;Mentorship;Outcome;peer;peer coaching;peer networks;programs;recruit;Research;Resources;Rhode Island;skills;student mentoring;Students;Surveys;Technical Expertise;Training;Training Activity;training opportunity;Training Programs;undergraduate student;Underrepresented Students;Universities

PROJECT_TITLE: Administrative Supplement for the URI ESTEEMED Training Program at the University of Rhode Island: Enhancement of Training Outcomes and Mentor Training


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rural Health;Social Determinants of Health;Vaccine Related

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: The Sars-CoV-2 pandemic presented unprecedented challenges in many areas of healthcare, such as accurately forecasting the need for critical resources linked to public health interventions. This research develops novel multi-task graph constrained machine-learning techniques to jointly predict related resources at the local level, including behavioral information. These methods are developed utilizing data from the RadX projects in West Virginia, combining statewide public health surveillance and hospitalization data, and have generalizability beyond Sars-Cov-2 to other public health crises.

PI_NAMEs: PRICE, BRADLEY  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: 2019-nCoV;Acceleration;Age;Appalachian Region;Area;Bachelor's Degree;Behavior;behavior change;Behavioral;care seeking;Cities;Collection;Common Data Element;Communicable Diseases;Communities;Complex;COVID-19;COVID-19 outbreak;COVID-19 pandemic;COVID-19 patient;COVID-19 testing;Data;Data Sources;Death Rate;deep learning;Development;Disease;Disease Outbreaks;Disparity;Economics;Educational Status;Emergency Situation;Emerging Communicable Diseases;Environmental Risk Factor;epidemic response;Event;Face;Future;Graph;health disparity;Healthcare;hospital care;Hospitalization;Hospitals;Household;Incidence;Income;Individual;insight;Knowledge;Learning;Life Expectancy;Link;Location;Machine Learning;machine learning framework;Measures;Methods;Mind;mortality;multitask;next generation;novel;Outcome;pandemic disease;pandemic response;Persons;Phase;Population;Population Surveillance;Poverty;predictive modeling;Public Health;public health intervention;RADx;RADx Underserved Populations;Research;Resource Allocation;Resources;response;Rural;rural America;rural area;rural dwellers;Rural Population;Sampling;Science;Secondary to;Severity of illness;social;social health determinants;sociodemographics;Stable Disease;statistical learning;Surveys;Techniques;Technology;Testing;Time;tool;United States;urban area;Vaccination;vaccine acceptance;West Virginia

PROJECT_TITLE: Leveraging COVID-19 Insights to Develop Novel Behavior-Informed Multi-Task Machine Learning Frameworks for Targeted Public Health Interventions in Rural America

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Natural Products

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: Project Narrative  The human microbiome consists of a dizzying array of bacteria that communicate and compete with one another using a chemical language consisting of secreted secondary metabolites. Among these microbes, Corynebacteria have recently emerged as important skin and upper respiratory tract residents that can cause opportunistic and difficult-to-tread infections, although their secondary metabolomes and how they interact with their environment remains unknown. In this proposal, we will use state-of-the-art methods to characterize the secondary metabolomes of three corynebacterial strains and to elucidate their roles in intra-genus, inter- genus, and inter-kingdom interactions, thus deepening our understanding of these bacteria and contributing to knowledge that can be used to develop therapies against corynebacterial infections.

PI_NAMEs: SEYEDSAYAMDOST, MOHAMMAD R (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: antagonist;Bacteria;beneficial microorganism;Biological Assay;Biology;Cells;Chemical Warfare;Chemicals;clinically relevant;Communication;Corpus striatum structure;Corynebacterium;cytokine;cytotoxicity;Dizziness;Environment;Genes;Genome;Goals;Grant;Health;Human;Human body;Human Microbiome;Infection;Knowledge;Language;Life Style;Light;Mass Spectrum Analysis;member;metabolome;Methods;Microbe;microbiome;microbiome components;multi-drug resistant pathogen;Natural product discovery;Natural Products;Nutrient;Operon;Opportunistic Infections;opportunistic pathogen;pathogen;Production;quorum sensing;resident commensals;Role;screening;secondary metabolite;Skin;small molecule;Staphylococcus aureus;Streptococcus;therapy development;Time;Upper respiratory tract;virtual;Virulence

PROJECT_TITLE: Talking with Small Molecules: Corynebacteria in the Human Microbiome

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE / RELEVANCE:  The cerebral cortex, where high-level sensory and motor processing, cognition, and integrative behavior occurs, contains thousands of distinct types of specialized nerve cells (neurons) to perform such complex tasks; cortical projection neurons (PN) are the class of “long-distance” neurons carrying information within and away from the cerebral cortex to the spinal cord and other brain structures, enabling cortex function. It is only partially understood how specific genes and molecules control how these neurons normally develop or are affected by abnormal development, degeneration, or dysfunction in human disorders, including ALS, spinal cord injury, Huntington's disease, cerebral palsy, intellectual disability, autism spectrum disorders; this work also has relevance for regeneration and drug development, since current genetic analysis systems have major gaps in their abilities. We propose to develop an innovative and unprecedented synthetic biology system to uniquely investigate function of specific genes in specific domains (“growth cones” and “synapses”) that control building of brain and spinal cord circuitry and proper brain function; this work also has potential for development of innovative and uniquely specific therapeutics for a range of developmental, degenerative, and neuropsychiatric disorders, and toward future central nervous system regeneration for acquired injuries like spinal cord injury.

PI_NAMEs: MACKLIS, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Affect;autism spectrum disorder;Axon;axonal pathfinding;Behavior;biological systems;Brain;Cell Nucleus;Cells;Central Nervous System;Cerebral cortex;Cerebral Palsy;Cognition;Communication;Complex;Cues;Data;Degenerative Disorder;Development;developmental disease;Diameter;Disease;drug development;extracellular;Functional disorder;Future;Genes;genetic analysis;Growth Cones;Human;Huntington Disease;In Vitro;in vivo;inducible gene expression;Injury;innovation;Intellectual functioning disability;Investigation;knock-down;Length;Link;Location;Maintenance;Maps;Measures;Mediating;Memory;Messenger RNA;Molecular;Motor;Mus;Natural regeneration;Nature;Nerve Regeneration;nervous system development;Nervous System Disorder;neural circuit;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;novel therapeutics;overexpression;Parents;postsynaptic;presynaptic;prevent;Process;Protein Biosynthesis;protein degradation;protein function;Proteins;Proteome;Proteomics;Regulation;RNA;Sensory;Specificity;Spinal Cord;Spinal cord injury;Structure;Synapses;synaptic function;synthetic biology;System;Systems Analysis;Systems Biology;Therapeutic;tool;transcriptome;Translations;Untranslated Regions;Work

PROJECT_TITLE: Synthetic System for Neuron Subtype- and Context-Specific Subcellular RNA/Protein Manipulation and Bioactive Delivery

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN FRANCISCO

ORG_NAME: SAN FRANCISCO STATE UNIVERSITY

PHR: Enter the text here, which is the new public health relevant information for your application. Using no more than two or three sentences, describe the relevance of this research to public health.  The NIH Bridges to the Doctorate Training Program at SFSU is a joint project between the Hispanic Serving Master’s institution, San Francisco State University (SFSU), and the pre-eminent PhD granting institution, the University of California San Francisco (UCSF). It prepares a diverse population of master’s students at SFSU to enter into top ranked biomedical Ph.D. degree programs such as UCSF, with the skills to successfully complete their Ph.D. degrees, en route to careers in the biomedical research workforce. The partnership between SFSU and UCSF addresses the need to diversify the scientific research community at the Ph.D. level.

PI_NAMEs: BLAKE, NICQUET M.J.;FUSE, MEGUMI M. (contact);RIGGS, BLAKE

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;programs

PROJECT_TITLE: SFSU/UCSF M.S. Bridges to the Doctorate Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Project Narrative The new CTSA K12 funding opportunity announcement (PAR-21-336) requires each K12 Scholar’s mentoring team to include a clinician, and for Scholars planning to lead or gain experience in clinical trials, a clinical trialist mentor. Formal mentor training specifically tailored to non-researcher clinician mentors, however, is not available. In this project, we aim to develop, implement, evaluate, and disseminate mentorship training tailored to clinicians planning to co-mentor researchers.

PI_NAMEs: CAHILL, ALISON G;TSEVAT, JOEL  (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Administrative Supplement;Award;Awareness;career;career development;Clinical;clinical practice;Clinical Research;Clinical Sciences;clinical training;Clinical Trials;Community of Practice;Competence;design;Educational Curriculum;Educational workshop;Elements;equity, diversity, and inclusion;Evaluation;evidence base;experience;Faculty;Funding Opportunities;Grant;Health Sciences;Hour;interest;K-Series Research Career Programs;Lead;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Modality;Modeling;Names;Persons;Postdoctoral Fellow;pre-doctoral;Program Sustainability;Publications;Research;Research Personnel;Research Project Grants;Site;success;symposium;Texas;Trainers Training;Training;Training Programs;Translating;Translational Research;translational scientist;Universities;virtual;Wisconsin;Work

PROJECT_TITLE: CTSA K12 Program at The University of Texas Health Science Center at San Antonio


NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative Research in neuroscience is crucial for attacking the causes of neurological and mental health disorders. If the field of neuroscience is to continue its rapid advance, neuroscientists must use, understand, and develop new technologies, acquire and analyze ever larger data sets, and grapple more directly with the complexity of neurobiological systems. The primary goal of this training program is to train a new generation of interdisciplinary neuroscientists with strong quantitative skills.

PI_NAMEs: CHASE, STEVEN M (contact);TORRES-OVIEDO, GELSY

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: academic minor;Appointment;Artificial Intelligence;Biomedical Research;Brain;Brain Diseases;Clinical Research;Cognition;college;computational neuroscience;computer science;data modeling;Data Set;Doctor of Philosophy;doctoral student;Environment;experience;Faculty;Fostering;Goals;Growth;Interdisciplinary Study;Internet;Machine Learning;Minority-Serving Institution;neural;neuromechanism;Neurosciences;programs;recruit;Research;Research Personnel;Schools;Students;summer program;tool;Training;Training Programs;undergraduate student;United States;Universities

PROJECT_TITLE: Interdisciplinary Training in Computational Neuroscience


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Patient Safety;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prescription Drug Misuse;Prevention;Primary Health Care;Substance Misuse

PHR: NARRATIVES The proposed study aims to harness advanced natural language processing and longitudinal neural network approaches to build on our previously developed machine-learning prediction algorithms to identify patients at risk for opioid overdose or opioid use disorder. We will develop the prediction tool using all-payer electronic health records (EHR), Medicaid claims, and Medicaid claims linked with EHR data from the One Florida Clinical Research Consortium and translate the risk prediction algorithms into a clinical decision support platform integrated into the EHR system to identify patients at high risk of overdose and opioid use disorder. This innovative and integrated platform will better guide clinical providers and health care systems for improving safety of opioid prescribing in clinical practice, and prevent opioid-associated adverse outcomes.

PI_NAMEs: LO-CIGANIC, WEI-HSUAN  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: acceptability and feasibility;Adopted;adverse outcome;Algorithms;Ambulatory Care Facilities;American;Classification;Clinic;Clinical;Clinical Data;clinical decision support;clinical practice;Clinical Research;cohort;Computer software;cost;Criminal Justice;Data;Data Set;Data Sources;deep neural network;design;Development;Diagnosis;Dose;Electronic Health Record;electronic health record system;Ensure;Feedback;Florida;Focus Groups;Funding;Guidelines;Health;Health Care Costs;Health system;Healthcare Systems;high risk;Homelessness;implementation outcomes;improved;Individual;innovation;insurance claims;Intervention;Interview;Letters;Link;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Measures;Medicaid;Medicare;Methods;model development;Naloxone;National Institute of Drug Abuse;Natural Language Processing;neural network;neural network algorithm;novel strategies;Nurse Practitioners;Opioid;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose risk;Patients;Pennsylvania;Performance;Persons;Pharmacy facility;Physician Assistants;Physicians;pilot test;Policy Maker;post implementation;prediction algorithm;predictive modeling;predictive tools;prescription opioid;prescription opioid misuse;prevent;primary care clinic;primary care provider;Process;Proctor framework;Productivity;programs;prototype;Provider;Public Health;recurrent neural network;Reporting;Research;Resources;response;Risk;risk mitigation;risk prediction;risk prediction model;risk stratification;Safety;Social Behavior;structured data;success;support tools;System;Time;tool;Translating;Translations;United States Centers for Medicare and Medicaid Services;Universities;usability;user centered design;user-friendly;Visit;Visualization;Work

PROJECT_TITLE: Developing and Evaluating a Machine-Learning Opioid Prediction & Risk-Stratification E-Platform (DEMONSTRATE)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Regenerative Medicine;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: WORCESTER POLYTECHNIC INSTITUTE

PHR: Project Narrative Tissue engineered heart valves (TEHVs), which have the potential to self-repair and grow with the patient, are a promising alternative to current valve replacements, especially for pediatric patients; yet TEHVs decellularized prior to implantation to minimize the immune response rely on repopulation of the matrix with host cells to facilitate remodeling of the matrix. The proposed project will determine how the dynamic mechanical environment of the valve regulates the attachment, infiltration, and differentiation of host cells into the TEHV matrix with the goal of optimizing TEHV design for host cell repopulation and adaptive remodeling under complex in vivo conditions. The mentoring activities will support students from marginalized communities.

PI_NAMEs: BILLIAR, KRISTEN L (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: 3-Dimensional;Adhesions;Administrative Supplement;Affect;Apoptosis;Behavior;Biomedical Engineering;Biomedical Research;Biopolymers;Bioprosthesis device;Bioreactors;Blood Vessels;cardiac tissue engineering;cell behavior;cell motility;Cell-Matrix Junction;Cells;Complex;Custom;design;Development;endothelial stem cell;Endothelium;Environment;experimental study;Extracellular Matrix;Fibrin;Fibroblasts;fluid flow;Funding;Gel;Goals;graduate student;heart valve replacement;Heart Valves;hemodynamics;Immune response;implantation;In Situ;in vivo;Incentives;Individual;Inequity;Infiltration;interstitial;Invaded;Lead;Liquid substance;marginalized community;mechanical stimulus;Mechanics;Mentors;Mentorship;Mesenchymal;Microfluidic Microchips;Microfluidics;migration;Monitor;novel;Operative Surgical Procedures;Outcome;parent grant;Patients;Pattern;pediatric patients;Periodicity;Phenotype;Population;programs;Proliferating;Proteins;repaired;response;Role;scaffold;shear stress;Signal Transduction;Signal Transduction Pathway;Smooth Muscle Myocytes;Stenosis;Stretching;Students;Surface;symposium;System;Testing;Time;Tissue Engineering;Tissues;Training;Transforming Growth Factor beta;undergraduate student;Universities;valve replacement;Vascular Smooth Muscle;Work

PROJECT_TITLE: The mechanics of host cell repopulation of engineered tissues


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: ATHENS

ORG_NAME: OHIO UNIVERSITY ATHENS

ORG_STATE: OH

PHR: PROJECT NARRATIVE Small regulatory RNAs are an important but severely understudied class of regulatory molecules in bacterial cells. We propose to create an sRNA mutant library, containing 88 mutants, in the human pathogen Neisseria gonorrhoeae and go on to phenotypically characterize these strains in an effort to identify sRNAs that may represent potential targets for therapeutic intervention.

PI_NAMEs: CARROLL, RONAN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Alleles;Antibiotic Resistance;Antibiotics;Bacteria;Base Sequence;Binding;Biological Assay;Categories;Cell Physiology;Cells;Characteristics;combat;Communities;Data Set;falls;Feasibility Studies;Future;Gene Expression Regulation;Generations;Genes;Genome;genome annotation;genomic locus;Gonorrhea;Gram-Negative Bacteria;Growth;High-Throughput RNA Sequencing;Human;Human body;human pathogen;improved;Individual;Infection;Intercistronic Region;Knock-out;Libraries;Metabolism;Morphology;mutant;Neisseria gonorrhoeae;novel;novel strategies;Oropharyngeal;pathogenic bacteria;Phenotype;Pilot Projects;Pilum;Play;Production;programs;Public Health;Rectum;reference genome;Reporting;Research;Resistance;Resistance development;resistant strain;Resources;RNA;Role;Serum;Sexually Transmitted Agents;Sexually Transmitted Diseases;Site;Small RNA;success;targeted treatment;Techniques;Therapeutic;Therapeutic Intervention;tool;transcriptome sequencing;transmission process;Treatment Failure;United States;Update;Virulence

PROJECT_TITLE: Generation and characterization of a small RNA mutant library in Neisseria gonorrhea

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Immunotherapy;Neurodegenerative;Neurosciences

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Oligomeric tau is a key pathogenic species of tau that is believed to drive the pathogenesis of Alzheimer’s disease end related dementias and there is a critical need to develop novel anti-oligomeric tau targeting therapies to treat AD and related dementias. Our objective is to create and assess an innovative immuno-gene therapy method using peripherally deliverable AAV-mediated CNS expression of a single chain variable domain derived from the TOC1 oligomeric tau antibody, which specifically binds to an epitope that relies on conformations induced during tau oligomerization (i.e. dimers and higher multimers, but not filamentous tau). This project will facilitate the initial development and validation of a highly novel anti-oligomeric tau therapy, holding the potential for a significant impact on the treatment of AD and related dementias.

PI_NAMEs: KANAAN, NICHOLAS M (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: adenovirus mediated delivery;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Antibodies;Antibody Therapy;antigen binding;Automobile Driving;Axonal Transport;Behavioral;Binding;Biological Assay;Blood Vessels;Brain;Capsid;Cell model;Cells;Central Nervous System Diseases;Clinical;cognitive performance;Complex;Coupled;Data;Degenerative Disorder;Dementia;Dependovirus;Development;dimer;Dimerization;Disease;disorder prevention;Ensure;Epitopes;expectation;Functional disorder;gene therapy;Generations;Human;human disease;Huntington Disease;immuno-gene therapy;Immunotherapeutic agent;Immunotherapy;Impairment;individualized medicine;innovation;Light;Link;Location;Lysosomal Storage Diseases;Macular degeneration;Measures;Mediating;Methods;mitochondrial dysfunction;Modification;Molecular Conformation;mouse model;multicatalytic endopeptidase complex;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neuronal Dysfunction;Neurons;neuropathology;neurotoxicity;novel;Nuclear;Organ;Parkinson Disease;Passive Immunization;Pathogenesis;Pathogenicity;Pathologic;Pathology;Peptide Signal Sequences;Peripheral;Phase;Phenotype;Physiological;Preclinical Testing;protein protein interaction;Proteins;Reagent;Recombinant adeno-associated virus (rAAV);research clinical testing;Role;Route;Series;Signal Transduction;Site;Synapses;System;Tail;targeted treatment;tau aggregation;tau mutation;tau Proteins;Tauopathies;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutically effective;Ubiquitin;Validation;Veins;Viral Vector;Wild Type Mouse

PROJECT_TITLE: Tau Oligomeric Complex 1 Antibody as a Novel Immuno-Gene Therapy for Tauopathy.

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE The goal of the Building Access to Food through Systems and Solidarity (BASIS) Study is to improve diet by providing culturally appropriate food access and attending to drivers that limit the ability to achieve nutrition security in Sunset Park – a community of Mexican and Chinese American families in Brooklyn, NY that has been hard-hit during the COVID-19 pandemic, has lagged in economic recovery, and where residents are disconnected from government supports. We aim to implement and evaluate a whole-of-community intervention that will prioritize sustainability in the long-term, in partnership with four farming/gardening organizations, one elementary school and three community-based organizations with programmatic offerings that will include linkage to federal, state and local aid and workforce development; a subsidized fresh produce box program, gardening and nutrition education; and a social marketing campaign to promote healthy eating. BASIS presents a powerful model to improve diet in immigrant communities by addressing determinants of food access in a community-centered, culturally competent way, and by fortifying community empowerment.

PI_NAMEs: YI, STELLA S (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Academia;Address;Administrative Supplement;anti-Asian;Asian Americans;Awareness;behavior change;built environment;Businesses;Chinese American;Climate;climate change;climate impact;Clinic;Collaborations;Communities;community empowerment;community engaged research;community intervention;community organizations;Community Workers;community-centered;COVID-19 pandemic;cultural competence;Data Sources;Diabetes Mellitus;Diet;Disparity population;Economics;Educational Curriculum;elementary school;empowerment;Equity;Essential worker;Ethnic Origin;Evaluation;experience;Face;Family;Farm;farmer;Feeling;Food;Food Access;food insecurity;Food Policy;Fortification;Fright;Gender;Generations;Goals;Government;Health;health care service;Healthcare;Healthy Eating;Immigrant;Immigrant community;improved;Individual;Inequity;Infrastructure;infrastructure development;Investments;Justice;Knowledge;Language;Latinx;Learning;Lived experience;Low income;marginalization;Medical Students;Medicine;Mental Health;Mentorship;Methods;Mexican Americans;model building;Modeling;Movement;Neighborhoods;New York;non-alcoholic fatty liver disease;nutrition;nutrition education;occupational hazard;Outcome;Outcome Assessment;pandemic disease;parent grant;Parents;perceived discrimination;Personal Satisfaction;population health;pressure;professional atmosphere;Program Development;programs;psychologic;public health research;Race;Radar;Recovery;Research;Role;Science;Security;Shame;social;social cohesion;Social Justice;Social Marketing;solidarity;stress management;stressor;Students;success;Sun Exposure;Syndrome;System;Techniques;Training Programs;Unhealthy Diet;Vaccination;volunteer;Workforce Development

PROJECT_TITLE: Administrative Supplement - Building Access to Food through Systems and Solidarity