FUNDING_MECHANISM: OTHERS

ORG_NAME: VETERANS AFFAIRS MED CTR SAN FRANCISCO

PHR: Cognitive processing therapy (CPT) and prolonged exposure therapy (PE) were widely disseminated as recommended posttraumatic stress disorder (PTSD) treatments. However, post-9/11 Veterans with PTSD rarely initiate CPT or PE, especially as an initial treatment. Little research has explored the combinations and sequences of psychosocial and medication treatments that Veterans receive (“treatment sequences”). One common and understudied treatment sequence begins with stabilization treatment, which is designed to prepare Veterans for CPT or PE. There is a significant research gap in understanding how treatment sequence affects initiation of CPT or PE. The proposed research is an innovative, mixed-methods approach to assessing the impact of variability in treatment sequence, including stabilization treatment, on initiation of CPT or PE and applying this knowledge by developing a health services intervention that facilitates timely transition to CPT or PE. Research aims can improve PTSD treatment by increasing initiation of and reducing disparities in CPT/PE.

PI_NAMEs: HOLDER, NICHOLAS  (contact)

PROJECT_TERMS: acceptability and feasibility;access disparities;Advocate;Affect;Area;Base Sequence;biopsychosocial;career;Caring;Characteristics;Clinical Practice Guideline;Cognitive;Collaborations;Combination Medication;common treatment;comparison intervention;Coping Skills;Data;Decision Making;design;Development;Diagnosis;Disparity;disparity reduction;Effectiveness;Electronic Health Record;Emotional;Ensure;ethnic minority;Evaluation;experience;Future;Goals;group intervention;Group Psychotherapy;hazard;Health Services;Health Services Accessibility;Health Services Research;Hybrids;implementation research;implementation science;improved;improved outcome;innovation;interest;Intervention;Interview;Knowledge;Longitudinal cohort;men;Mental Health;Methodology;Methods;novel strategies;Outcome;Patient Preferences;Pharmaceutical Preparations;pilot trial;post 9/11;Post-Traumatic Stress Disorders;pragmatic trial;primary outcome;Procedures;psychosocial;Psychotherapy;Qualitative Methods;racial minority;Randomized;Recommendation;Recovery;Research;Research Methodology;Research Personnel;Risk;Sampling;secondary outcome;service intervention;Services;shared decision making;Site;sociodemographic disparity;sociodemographics;success;Suicide prevention;Testing;therapy development;Time;Training;Translating;treatment as usual;treatment disparity;treatment research;Veterans;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Improving Care for Veterans by Understanding and Facilitating Transition to Recommended PTSD Treatment

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The number of Veterans living with dementia (VLWD) is expected to increase by 2030 to nearly 340,000; these Veterans and their caregivers often have complex psychosocial and health needs. Coordinating this care is complicated by the fact that most VLWD are Medicare-eligible and therefore use care both through the VA and Medicare, though dual use is often associated with duplication of services and potentially inappropriate care. In light of these complexities, a 2019 VHA directive mandated that VA facilities establish a Dementia System of Care to provide person-centered services for these VLWD. The goals of this project are to examine the links between dual use, continuity of care, and the patient-centered outcome of home time. Then, we will interview staff and VLWD-caregiver dyads at high- and low-performing VA facilities to identify dementia care delivery strategies that maximize home time. Finally, with a Stakeholder & Expert Panel that includes clinicians, researchers, and a VLWD-caregiver dyad, we will identify promising strategies for a dementia care toolkit.

PI_NAMEs: KREIN, SARAH  (contact);MAUST, DONOVAN T

PROJECT_TERMS: Aging;Ambulatory Care;Attention;care coordination;care delivery;care seeking;care systems;Caregivers;caregiving;Caring;Case Manager;Collaborations;Communities;Community Healthcare;Complex;Continuity of Patient Care;cost;Data;Dementia;dementia care;Dementia caregivers;design;Drug Prescriptions;Eligibility Determination;Enrollment;expectation;experience;Family;Goals;Guidelines;Health;Health Services Accessibility;high risk;Home;Hospitalization;improved;indexing;Individual;innovation;insight;interest;Intervention Trial;Interview;Knowledge;Learning;Left;Light;Link;Long-Term Care;Medical center;Medicare;Medicare claim;member;Methodology;Methods;military veteran;older adult;opioid mortality;opioid overdose;Outcome;Outpatients;Patient-Focused Outcomes;Patients;Performance;person centered;Pharmaceutical Preparations;Policies;preference;prescription opioid;primary care practice;primary outcome;programs;Provider;psychosocial;Publishing;Quality of Care;Recording of previous events;research and development;Research Personnel;Research Priority;Services;skills;Source;Structure;System;Systems Development;Time;tool;Variant;Veterans;Visit;Voice;Work

PROJECT_TITLE: Putting the puzzle together: Leveraging dual use to improve care for Veterans living with dementia

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The objective of this training grant is to develop the next generation of physicians and scientists for the successful pursuit of new knowledge to understand diseases, enhance health, and develop new treatments for digestive diseases.

PI_NAMEs: MALHI, HARMEET  (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Multidisciplinary Training in Digestive Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-T (J1)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative Evidence-based programs that reduce the risk of children developing mental health disorders are rarely sustained in schools. Research that identifies barriers to sustainment is thus needed. The proposed study aims to address this gap by identifying teacher, intervention, and school level factors that influence sustainment.

PI_NAMEs: MCLEOD, BRYCE DOUGLAS (contact);SUTHERLAND, KEVIN SCOTT

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Address;Adherence;aged;Atmosphere;Behavior;Behavior Disorders;burnout;Child;Child Development;Climate;cohort;Communities;Competence;Data;design;Development;Education;elementary school;Emotional disorder;Evidence based program;Face;Feedback;Foundations;Funding;Goals;implementation determinants;improved;improved outcome;inclusion criteria;Individual;Interruption;Intervention;Measures;Mental disorders;Mental Health;Methods;Modification;multilevel analysis;National Institute of Mental Health;Outcome;Phase;post intervention;Prediction of Response to Therapy;Predictive Factor;Problem behavior;Program Sustainability;Property;prospective;Psychometrics;Public Health;public health priorities;Qualitative Methods;Randomized;Randomized, Controlled Trials;Research;Research Methodology;Resources;Risk;Risk Reduction;Sampling;Schools;Self Efficacy;Series;social skills;standard measure;sustainability framework;Target Populations;teacher;Testing;theories;third grade;Time;Training;treatment program;usability

PROJECT_TITLE: Multi-level determinants of implementation and sustainment in the education sector

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-J(04)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The hippocampus plays a critical role in resolving memory interference, which happens when one long-term memory is confused with another similar one. The proposed research will leverage novel computational methods to identify how patterns of activity in the human hippocampus change and adapt over time so as to minimize the potential for memory interference. The training focuses on gaining expertise in computational methods, deepening theoretical knowledge of memory systems, and professional development activities to foster a successful transition to the next career stage and beyond.

PI_NAMEs: GUO, WANJIA  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TITLE: Remapping of episodic memories in the human hippocampus


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Embryonic - Human;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: ATHENS

ORG_NAME: ARUNA BIOMEDICAL, INC.

ORG_STATE: GA

PHR: Project Narrative (3 sentences)  Traumatic brain injury (TBI) is a “silent epidemic” as 2.53 million patients visit the emergency department every year of which 56,800 patients die. Aruna Bio has recently developed a multimodal neuroprotective and regenerative neural stem cell extracellular vesicle (NSC EV) product, AB126™, to treat TBI that has demonstrated significant efficacy for TBI indications. The successful completion of the proposed study will provide key information pertaining to AB126™ dosage, therapeutic effects on TBI pathophysiology (edema, hemorrhage) and functional outcomes, toxicity, and potential adverse side effects that will serve as the basis for an IND submission and future clinical trials.

PI_NAMEs: STICE, STEVEN L (contact);WEST, FRANKLIN D

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Accident and Emergency department;Acute;angiogenesis;animal efficacy;Animal Testing;Area;Assessment tool;Attenuated;Brain;Cerebral hemisphere hemorrhage;Cerebrum;Chemistry;Chronic;Clinical;Clinical Trials;clinically relevant;commercialization;controlled cortical impact;Data;Development;dosage;Dose;Edema;efficacy evaluation;efficacy study;Emergency department visit;Epidemic;Evaluation;Event;experience;extracellular vesicles;Family suidae;Functional disorder;Functional Magnetic Resonance Imaging;functional outcomes;Funding;Future;Goals;Good Manufacturing Process;Government Agencies;Grant;Health;Hemorrhage;Hospitalization;Human;Impairment;Industry;Inflammation;Investigational Drugs;Investigational New Drug Application;Ischemic Stroke;KDR gene;Laboratories;Legal patent;Lesion;Magnetic Resonance Imaging;manufacture;manufacturing capabilities;Medical Care Costs;Methods;Modality;Modeling;Monitor;Motor;motor function improvement;motor function recovery;multimodality;nerve injury;nerve stem cell;nestin protein;neural network;neurogenesis;neuroinflammation;Neurologic;neurological recovery;neuroprotection;New Drug Approvals;novel;old mice;Patients;pharmacologic;Phase;porcine model;Positioning Attribute;preclinical study;Predisposition;Prevalence;programs;Rattus;Recommendation;Recovery;regenerative;Rehabilitation therapy;Resolution;response;response to injury;Rodent;Rodent Model;Safety;side effect;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Stroke;stroke model;Supportive care;TBI Patients;TBI treatment;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Tissues;Toxic effect;Traumatic Brain Injury;Traumatic Brain Injury recovery;Treatment Efficacy;United States Food and Drug Administration;United States National Institutes of Health;Universities;Walking;white matter

PROJECT_TITLE: Neural Stem Cell Extracellular Vesicle Treatment for Traumatic Brain Injury


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Prevention

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative This competitive renewal application for years 31 to 35 of an R25 award at The University of Texas MD Anderson Cancer Center, Cancer Prevention Education: Student Research Experiences, requests support for 25 students in 10-week educational experiences each year for 5 years in multidisciplinary mentored cancer prevention research and career development. The Program recruits graduate and undergraduate students from the basic biomedical sciences, biostatistics, epidemiology, genetics, behavioral and social sciences, nursing, medicine, pharmacy, and related public health disciplines. The overall educational objective is to provide short-term research experiences in cancer prevention research to students as a means of preparing them for careers in cancer prevention research.

PI_NAMEs: CHANG, SHINE  (contact)

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Advisory Committees;anti-cancer research;Award;behavioral and social science;Biometry;broadening participation research;Cancer Control;cancer prevention;career;Career Choice;career development;Career Exploration;cohort;Compensation;COVID-19;COVID-19 pandemic effects;Curiosities;Decision Making;design;Development;Discipline;Discipline of Nursing;Education;Educational Activities;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Ensure;Epidemiology;essays;Evaluation;Event;experience;Exposure to;Faculty;faculty mentor;Family;Feedback;Feeling;forging;Friends;Future;Genetic;Goals;graduate school;graduate student;Group Meetings;Health Professional;Home;Hospitals;improved;innovation;insight;Institution;Instruction;interest;Intervention;Journals;Leadership;Learning;Letters;Lifting;Link;Malignant Neoplasms;Medicine;Mentors;Methods;multidisciplinary;novel;pandemic disease;Peer Review;perceived discrimination;Performance;Personal Satisfaction;Persons;Pharmacy facility;pilot test;Population;Population Scientist Supplement (R25);Positioning Attribute;Prevention education;Prevention Research;Process;professional students;Program Evaluation;programs;Progress Reports;Public Health;Publications;Qualifying;Recovery;recruit;Research;research and development;Research Ethics;Research Project Grants;Research Training;resilience;responsible research conduct;Review Committee;Science;Scientist;Selection Criteria;Self Perception;Site;skill acquisition;Social support;Structure;Student Selections;Students;success;summer research;summer student;symposium;Testing;Time;Training;Training Programs;Travel;undergraduate student;Underrepresented Populations;University of Texas M D Anderson Cancer Center;Work

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The interface of behavioral and biomedical sciences is one of the most vibrant frontiers of science today. The Behavioral-Biomedical Interface Program at the University of Iowa is training the next generation of diverse behavioral researchers to utilize rigorous biomedical methodologies and conceptual frameworks to enable them to make transformative breakthroughs in understanding and addressing mechanisms that influence human health and disease.

PI_NAMEs: LUTGENDORF, SUSAN K (contact);TRANEL, DANIEL T.;VOSS, MICHELLE WEBB

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Behavioral;Disease;Health

PROJECT_TITLE: Understanding Health and Disease at the Behavioral-Biomedical Interface

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: Tampa

ORG_NAME: JAEB CENTER FOR HEALTH RESEARCH, INC.

ORG_STATE: FL

PHR: Project Narrative Visual impairment and blindness from retinal diseases remain a significant public health problem that continues to grow in epidemic proportions in the United States and globally despite advances in treatment. The DRCR Retina Network is a collaborative organization dedicated to improving vision and quality of life for people with retinal diseases through high quality, collaborative, multicenter clinical research of diabetic retinopathy, age-related macular degeneration, and other retinal diseases of public health importance. Network studies addressing novel treatments for diabetic macular edema and proliferative diabetic retinopathy have already had a major direct impact on clinical care guidelines and practices worldwide for diabetic eye disease, making the Network uniquely poised for further impactful contributions in the fight against vision loss from retinal diseases.

PI_NAMEs: GLASSMAN, ADAM R (contact);MARTIN, DANIEL F;SUN, JENNIFER KATHERINE

PROGRAM_OFFICER_NAME: SHOAIBI, AZADEH

PROJECT_TERMS: Address;Age related macular degeneration;Algorithms;Artificial Intelligence;Authorization documentation;Blindness;Childhood;Clinic;Clinical;clinical care;clinical practice;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communities;comparative effectiveness study;Congresses;cost effectiveness;Data Set;Dedications;design;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Disease;Economic Burden;Ensure;Epidemic;Evaluation;Eye diseases;fighting;Financial Support;Fostering;Foundations;Funding;Generations;Genetic;Goals;Grant;Growth;Guidelines;Human Resources;Image;improved;Individual;Industry;Industry Collaboration;Infrastructure;innovation;International;Knowledge;Leadership;macular edema;meetings;Mentors;Methods;Mission;Multi-site clinical study;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Pathology;Patients;Peer Review;Performance;Persons;Pharmaceutical Preparations;Policies;predictive marker;preservation;Principal Investigator;Productivity;Prognostic Marker;proliferative diabetic retinopathy;Protocols documentation;Public Health;public health priorities;Publications;Quality of life;Reading;Reporting;Research;Research Infrastructure;Research Personnel;research study;Resources;Retina;Retinal Diseases;retinal imaging;Retinal Vein Occlusion;Site;standard of care;Structure;success;Testing;Time;United States;United States National Institutes of Health;Vision;Visual;Visual impairment

PROJECT_TITLE: DRCR Retina Network

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (10)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The study aims to reduce morbidity and enhance survival rates in patients with oral cavity tumors. We develop a targeted Dual Function Antibody Conjugate (DFAC) amenable to online deep tissue photoacoustic imaging (PAI) guided surgery followed with targeted photodynamic therapy (PDT) in one intraoperative setting. PAI will enable detection of deep tumor margins that are currently available only through palpation or slower histopathological methods. PDT specifically kills microscopic residual disease, that causes recurrence in most patients, without damage to surrounding healthy tissue. Overall our proposed comprehensive theranostic solution will overcome challenges such as high recurrence rate and low quality of life in oral cancer management.

PI_NAMEs: HASAN, TAYYABA  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: Adjuvant;Age;Algorithms;Antibodies;antibody conjugate;base;bench to bedside;bench-to-bedside translation;Biological Markers;Biology;Biomedical Engineering;cancer cell;Cancer Patient;Cetuximab;Chemicals;chemoradiation;Clinic;Clinical;Clinical Research;clinical translation;Collaborations;contrast imaging;cost;Custom;design;Detection;Development;Diagnostic;Disease;Disease-Free Survival;Dose;Drug Kinetics;Dyes;Ear;effective therapy;Engineering;Ensure;Epidermal Growth Factor Receptor;Evaluation;Excision;experience;Eye;FDA approved;first-in-human;Fluorescence;fluorescence imaging;functional loss;General Hospitals;Geography;Goals;healing;human tissue;hydrophilicity;Image;image guided;Image-Guided Surgery;imaging probe;imaging system;improved;In Vitro;Industrialization;Industry;industry partner;Infrastructure;innovation;insight;interdisciplinary approach;Invaded;Investigational Drugs;Lesion;Light;Local Therapy;Macular degeneration;malignant mouth neoplasm;Malignant Neoplasms;malignant tongue neoplasm;Massachusetts;Methods;Microscopic;Modality;Morbidity - disease rate;mouse model;Mouth Neoplasms;Mucous Membrane;New Drug Approvals;Noise;Normal tissue morphology;Operative Surgical Procedures;Optics;Oral;Oral cavity;Otolaryngology;Outcome;overexpression;Palpation;Patients;Phase;Phase 0 Clinical Trial;photoacoustic imaging;Photochemistry;Photosensitizing Agents;Positioning Attribute;pre-clinical;Primary Neoplasm;Production;Property;PUVA Photochemotherapy;Quality of life;Radiation Tolerance;Rattus;Recurrence;Recurrent disease;Reporting;Research;Resected;Residual Neoplasm;Residual state;Resolution;Rodent;Salivary Glands;Sample Size;Signal Transduction;skills;standard of care;Structure;Surface;Surgeon;Survival Rate;systemic toxicity;targeted treatment;theranostics;Therapeutic;therapeutic evaluation;Time;Tissue imaging;Tissues;Tongue;Toxic effect;Toxicology;Treatment Efficacy;Treatment outcome;tumor;Tumor Burden;Tumor Cell Invasion;Tumor Tissue;Ultrasonography;ultrasound

PROJECT_TITLE: Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapy


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Relevance PWID continue to have high rates of HIV and high mortality rates in the US. The proposed methods have the potential to rapidly identify hotspots without major HIV testing initiatives and can help health departments target HIV prevention and care efforts. The proposed intervention will cover a large geographic area and enhance access to HIV prevention and care materials, peer education, and naloxone.

PI_NAMEs: LATKIN, CARL A (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acute Hepatitis C;Address;AIDS prevention;Area;Baltimore;Baseline Surveys;Behavior;Behavioral;Caring;Censuses;Cessation of life;Characteristics;Cities;Cluster randomized trial;Computer software;Data;Death Rate;Ecological momentary assessment;Education;Equipment;evidence base;Geographic Locations;Goals;Health;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Transmission;high risk;high risk behavior;High School Student;HIV;HIV diagnosis;HIV drug resistance;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;HIV/HCV;Human immunodeficiency virus test;improved;Incidence;indexing;Infection;Injecting drug user;injection drug use;Injections;innovation;Intervention;Intervention Trial;Location;Maps;Maryland;Massachusetts;Methods;Naloxone;novel;novel strategies;Online Systems;Opioid;opioid overdose;opioid use;Outcome;Overdose;overdose death;overdose prevention;overdose risk;overdose risk behaviors;Participant;Patient Self-Report;peer;Pharmaceutical Preparations;prevent;Prevention;Privatization;programs;Randomized;rapid detection;Recording of previous events;recruit;Research;Risk;Risk Behaviors;Risk Reduction;Sampling;social;social network intervention;social norm;standard of care;Surveys;Technology;Testing;Time;Training;transmission process;treatment arm;trend;Viral Load result;virology;Washington

PROJECT_TITLE: A geospatial analysis of hotspots and targeted injection settings pilot intervention for HIV prevention among people who inject drugs in Baltimore, Maryland

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE People who inject drugs (PWID) are at substantial risk for HIV. However, they often do not receive recommended services, including HIV pre-exposure prophylaxis (PrEP) and other indicated care to address their opioid use. We plan to study the impact of a novel approach, involving contingency management with stepped care to PrEP navigation, to improve PrEP adherence among PWID accessing community-based programs.

PI_NAMEs: EDELMAN, E. JENNIFER (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;adaptive intervention;Address;Adherence;AIDS prevention;Apical;Behavior;behavior change;Biological Markers;Blood;Caring;Case Management;Cities;Clinical Trials;Communicable Diseases;Communities;community academic partnership;community based service;community engaged research;Community Healthcare;compare effectiveness;Connecticut;contingency management;Data;design;Disease Outbreaks;disorder prevention;Dose;Dryness;effectiveness evaluation;effectiveness/implementation hybrid;Eligibility Determination;evidence base;experience;falls;flexibility;Goals;Harm Reduction;Health;HIV;HIV Infections;HIV risk;HIV/STD;implementation science;improved;Incentives;Individual;individual response;infectious disease treatment;information gathering;Injecting drug user;injection drug use;innovation;Intervention;Leadership;marginalized population;Massachusetts;Medical;medication compliance;medication for opioid use disorder;Modeling;Motivation;motivational enhancement therapy;multidisciplinary;National Institute of Drug Abuse;Needle-Exchange Programs;novel;novel strategies;opioid epidemic;opioid treatment program;opioid use;opioid use disorder;Outcome;Pamphlets;Participant;Patient Self-Report;Persons;point of care;point of care testing;pre-exposure prophylaxis;Prevention;preventive intervention;primary outcome;Prize;process evaluation;programs;Provider;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;Reducing Agents;Reproducibility;Resources;Rewards;Risk;Risk Behaviors;Risk Reduction;service organization;Services;Site;Spottings;substance use;surveillance data;Testing;Training;treatment as usual;United States;United States Substance Abuse and Mental Health Services Administration;uptake;Urine

PROJECT_TITLE: Promoting HIV risk reduction among people who inject drugs: A stepped care approach using contingency management with PrEP navigation


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period

PHR: Project Narrative This application is for a five-year extension of funding for the Pediatric Eye Disease Investigator Group (PEDIG) – an open clinical research network of pediatric ophthalmologists and pediatric optometrists that was formed to conduct clinical research in strabismus, amblyopia, and other childhood eye conditions. Telehealth through ocular photography and at-home visual acuity testing as well as an amblyopia treatment algorithm will be explored to increase access to care, dissemination, and generalizability. The proposed studies in the current application would continue to advance the pediatric eye care field in evidence-based, diverse directions, improving care and quality of life for children with eye conditions.

PI_NAMEs: KRAKER, RAYMOND  (contact);PINELES, STACY ;WEISE, KATHERINE K

PROGRAM_OFFICER_NAME: EVERETT, DONALD F

PROJECT_TERMS: Academy;Address;Algorithms;Amblyopia;American;Area;care providers;Caring;cerebral visual impairment;Child;Childhood;childhood cataract;clinical practice;Clinical Research;clinical research site;Collaborations;comparative effectiveness study;Conduct Clinical Trials;cost;Decision Making;Dedications;Development;Disease;Enrollment;equity, diversity, and inclusion;evidence base;Evidence based treatment;Eye;Eye diseases;follow-up;Foundations;Funding;Future;Grant;Health Services Accessibility;Home;improved;Infrastructure;Internet;Knowledge;Leadership;leadership development;Manuscripts;meetings;Methodology;Minority Groups;Modeling;Myopia;Nasolacrimal duct structure;novel;Observational Study;Obstruction;ocular imaging;Ophthalmologist;Ophthalmology;Optic Neuritis;optimal treatments;Optometrist;Optometry;organizational structure;Pathologic Nystagmus;Pattern;Photography;Program Development;prospective;Protocols documentation;Publications;Publishing;Quality of life;Randomized;randomized trial;randomized, clinical trials;recruit;Recruitment Activity;Refractive Errors;Research;Research Personnel;Retina;Retinopathy of Prematurity;Sample Size;Site;Strabismus;Strategic Planning;telehealth;Telephone;Testing;Time;Training;Underrepresented Minority;Uveitis;Visit;Visual Acuity;working group;Writing

PROJECT_TITLE: Pediatric Eye Disease Investigator Group Coordinating Center


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This postdoctoral training program at the University of California, San Francisco (UCSF) develops new scientists to conduct high-impact work in substance use disorders (SUD) treatment and services research in a range of high-priority patient populations and settings. Key program strengths include work in HIV, health equity, digital health interventions, health systems, and emerging therapeutics. We aim to continue our highly successful training program, with support for 5 postdoctoral trainees at any given time, as we build on a track record of success and integrate new strategies to address the needs of people with SUD and make substantial contributions to the research field.

PI_NAMEs: SATRE, DEREK D (contact);TSOH, JANICE Y

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Health Services Research;Substance Use Disorder;Training Programs

PROJECT_TITLE: Substance Use Disorders Treatment/Services Research Training Program

STUDY_SECTION: NIDA

STUDY_SECTION_NAME: Career Development Education and Training Study Section[NIDA-K]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Los Angeles

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative We propose to use the integrated approach combining multi-omics, single cell imaging, and CRISPR-based locus-specific gene targeting to elucidate the blood flow regulation of vascular functions via the nuclear envelop- epigenetics mechanisms. The identification of key genomic regions and genes will allow us to develop noninvasive therapeutic tools to mitigate vascular function under pathophysiological conditions. The study will also provide novel knowledge for atherosclerosis prevention, treatment, and management.

PI_NAMEs: CHIEN, SHU ;WANG, YINGXIAO  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: aortic arch;Area;atherogenesis;atheroprotective;Atherosclerosis;Biosensor;Blood flow;Blood Vessels;Carotid Arteries;Cell Fate Control;Cell Physiology;Cells;cellular imaging;Chemicals;ChIP-seq;Chromatin;chromatin remodeling;Clustered Regularly Interspaced Short Palindromic Repeats;Coupling;CRISPR interference;CRISPR-mediated transcriptional activation;emerin;endonuclease;Endothelial Cells;Engineering;Epigenetic Process;epigenetic regulation;epigenome;experimental study;Fluorescence Resonance Energy Transfer;Focused Ultrasound;Functional disorder;functional outcomes;gain of function;Gene Targeting;Genes;Genetic;Genome;genomic locus;genomic profiles;Genomic Segment;Genomics;Guide RNA;histone modification;Histones;Homeostasis;Image;In Vitro;in vivo;Individual;Inflammation;inhibitor;intravenous administration;Investigation;Knowledge;Laboratories;Lamins;Ligation;Link;Location;loss of function;Magnetic Resonance;mechanotransduction;Modeling;Monitor;mouse model;multiple omics;Mus;Nature;novel;Nuclear;Nuclear Envelope;Pattern;Play;Prevention;Proteins;recruit;Regulation;Repression;Role;Series;shear stress;single-cell RNA sequencing;Site;small hairpin RNA;System;Testing;Therapeutic;Thoracic aorta;Time;Tissues;tool;Transcriptional Regulation;transcriptome;transcriptomics;Validation;Vascular Diseases;Vascular Endothelial Cell;Viral;Visualization

PROJECT_TITLE: Integration of single-cell imaging and multi-omics sequencing to study EC mechano-pathophysiology

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Radiation Oncology

ORG_DEPT: PHARMACOLOGY

PHR: Narrative Tumor recurrence is one of the largest clinical challenges in cancer. It is widely accepted that small numbers of tumor cells persist in non-proliferating (dormant) state until cells re-enter the cell cycle, thus originating metastases. The elucidation of the mechanisms, by which tumor cells are reawakened from dormancy, is crucial to achieve eradication of lung cancer. This application will address this problem by studying specific mechanisms regulating dormancy by neutrophils, evaluate their clinical significance and potential therapeutic intervention.

PI_NAMEs: ZHANG, RUGANG  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Adjuvant Chemotherapy;Adrenergic Agents;Adrenergic Receptor;autocrine;Binding;cancer cell;cancer therapy;cancer type;Cell Cycle;Cells;Cessation of life;Characteristics;chemotherapy;Chemotherapy and/or radiation;Clinical;clinically significant;Data;Development;Distant;Distant Metastasis;DNA Damage;Elements;Excision;Felis catus;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Goals;Hormones;Human;In complete remission;Lesion;Leukotriene B4;Lipid Peroxidation;Lipids;Lipopolysaccharides;Lipoxygenase;Lung;lung cancer cell;Lymphocyte;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;Mus;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Neurosecretory Systems;neutrophil;Non-Small-Cell Lung Carcinoma;Norepinephrine;novel;Operative Surgical Procedures;oxidized lipid;Paracrine Communication;Patients;Peroxidases;prevent;Primary Neoplasm;Process;Proliferating;Proteins;radiation response;Radiation therapy;receptor;receptor for advanced glycation endproducts;Receptor Signaling;Recurrence;Recurrent tumor;Regulation;S100A8 gene;senescence;senescent cell;Signal Transduction;Site;Stress;System;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Tissues;TLR4 gene;TP53 gene;treatment choice;treatment response;tumor;Tumor Suppressor Genes;Up-Regulation;WNT Signaling Pathway

PROJECT_TITLE: Regulation of tumor recurrence by stress activated neutrophils

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biodefense and Related Countermeasures;Brain Disorders;Dementia;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Transformation of microglia into reactive states is recognized as one of the major hallmarks of neurodegenerative disease including prion, Alzheimer’s, and Parkinson’s diseases. Very little is known about the role of microglia-driven phagocytosis in pathogenesis of prion disease. This study will inform whether phagocytic activity should be targeted as a potential therapeutic strategy for treating prion diseases.

PI_NAMEs: BASKAKOV, ILIA V (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;Alzheimer's Disease;Animals;Apoptotic;Award;Biological Markers;Cells;Clinical;conditional knockout;Creutzfeldt-Jakob Syndrome;Data;design;Disease;Disease Progression;Eating;Effectiveness;effectiveness testing;Event;FDA approved;Flow Cytometry;Galactose;Goals;Human;inhibitor;ITGAM gene;Knowledge;Macrophage-1 Antigen;Mediating;Microglia;mouse model;Mus;Myeloid Cells;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;Onset of illness;Parkinson Disease;Pathogenesis;Pathway interactions;Phagocytes;Phagocytosis;Phenotype;Population;Prion Diseases;Prions;PrPSc Proteins;Purinoceptor;receptor;Role;screening;Signal Transduction;Solid;Synaptosomes;Terminally Ill;Testing;Therapeutic;Therapeutic Intervention;timeline;uptake;Work

PROJECT_TITLE: Role of microglial phagocytosis in prion diseases

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Hematology;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PHYSIOLOGY

PHR: Narrative (relevance) Stroke is one of the major causes of disability and mortality worldwide. Injury to white matter (WM) is present in most stroke patients. Importantly, stroke in small brain vessels, occurs in subcortical WM regions and accounts for 25% of all strokes, and is the second leading cause of dementia. Despite such clinical importance, the pathophysiology of WM stroke is relatively poorly understood. Moreover, at the present there is no therapy for prevention and/or treatment of WM stroke. Based on our previous studies, activated protein C (APC) therapy has been successfully translated from bench to clinical trials in stroke patients. However, whether activation of APC pathways in the WM is beneficial or not during WM stroke, and/or whether new APC-based therapies can be extended to treat WM stroke, remains unknown, and will be addressed by the proposed studies.

PI_NAMEs: MACK, WILLIAM J (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: activated Protein C;activated protein C receptor;Address;Agonist;Amino Acid Sequence;analog;Anti-Inflammatory Agents;Anticoagulants;Apoptotic;arrestin 2;Arteries;Astrocytes;Axon;behavior test;Biological Products;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;cell type;Cells;Cerebral endothelium;Clinic;Clinical;Clinical Trials;Collaborations;Cytoprotection;Data;Dementia;disability;Endothelium;Engineering;Exhibits;Extravasation;Factor Va;Factor VIIIa;Fiber;Functional disorder;Gene Expression;Generations;Goals;GTP-Binding Proteins;improved;In Vitro;in vivo;in vivo Model;Inflammatory;Injury;insight;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Lesion;Ligands;Magnetic Resonance Imaging;Microglia;mimetics;Modeling;mortality;Mus;mutant;Mutation;N-terminal;Nerve Degeneration;Neurons;neuropathology;neuroprotection;novel;novel therapeutics;Oligodendroglia;PAR-1 Receptor;Pathway interactions;Peptides;peptidomimetics;phase II trial;Platelet Activation;Point Mutation;prevent;Prevention therapy;protective effect;Proteolysis;response;Role;Signal Transduction;Site;Stroke;stroke model;stroke patient;stroke therapy;success;Testing;Therapeutic;Thrombin;Toxic effect;Translating;Traumatic Brain Injury;vascular cognitive impairment and dementia;vasoconstriction;white matter;white matter injury

PROJECT_TITLE: Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE Our studies support the role of inflammatory stimulants in promoting mutant KRAS hyperactivation leading to a long-sustained pancreatic inflammation, irreversible acinar-to-ductal metaplasia, and pancreatic intraepithelial neoplasia. The objective of this proposal is to unravel the role of NADPH oxidases as a critical mediator linking inflammation to mutant KRAS hyperactivation and associated pathologic consequences. Knowledge gained from the current proposal will guide the design of new targets for prevention and treatment in humans of inflammation- associated pancreatic diseases.

PI_NAMEs: LU, WEIQIN  (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Ablation;Acinar Cell;Chronic;chronic pancreatitis;Clinical;Cysteine;Data;design;Disease;Docking;Duct (organ) structure;effective intervention;Enzymes;Fibrosis;gastrointestinal;Generations;Hospitalization;Human;Hyperactivity;Inflammation;Inflammation Mediators;Inflammatory;Knowledge;KRAS2 gene;KRASG12D;Lesion;Link;Mediator;Medical;Metaplasia;Modification;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;mutant mouse model;Mutation;NADPH Oxidase;novel;Oxidation-Reduction;Pancreas;pancreas development;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;Pancreatic Intraepithelial Neoplasia;Pancreatitis;Pathogenesis;Pathologic;Pathology;Patients;Prevention;Preventive;Reactive Oxygen Species;Risk Factors;Role;Signaling Molecule;Stimulant;Stimulus;Testing;Therapeutic;therapeutically effective;Tissue Sample;Work

PROJECT_TITLE: Unraveling the Role of NADPH Oxidase in Inflammation-associated Pancreatic Diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-T(90)]


ADMINISTERING_IC: HG

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Genomic variation is responsible for numerous rare diseases, for propensity for many common traits and diseases, for drug response, and is a key characteristic of cancer evolution. At present, our ability to characterize genetic differences far exceeds our capacity to interpret them either for basic research understanding or for clinical application. The Center for Critical Assessment of Genome Interpretation, operating on robust ethical foundations, will provide an evaluation of the current state of the art and help promote progress in understanding the impact of genomic variation.

PI_NAMEs: BRENNER, STEVEN E (contact);IOANNIDIS, NILAH MONNIER

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Adoption;Affect;Amino Acid Sequence;Artificial Intelligence;base;Basic Science;Blinded;Calibration;Characteristics;Clinical;clinical application;clinical practice;Communities;computerized tools;Computing Methodologies;Copy Number Polymorphism;Data;data acquisition;data dissemination;Data Set;Development;Disease;Educational workshop;Environment;Ethics;Evaluation;Evolution;exome;Experimental Models;experimental study;Foundations;Genetic;genetic information;genetic variant;Genetic Variation;Genome;genomic data;genomic variation;Germ Lines;Health;high standard;human disease;Human Genetics;Infrastructure;innovation;International;Knowledge;Machine Learning;Malignant Neoplasms;meetings;Methods;Molecular;multiple omics;Nucleotides;operation;outreach;Participant;Performance;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Privacy;Provider;Publications;Rare Diseases;response;RNA Splicing;Secure;Structure;symposium;trait;Trust;Variant;whole genome;Work


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Mental Health;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Narrative Hepatitis C virus infection (HCV) mortality exceeds that for HIV in the US and disproportionately affects racial and ethnic minorities. Our innovative mixed methods and multi-site study will advance the National Viral Hepatitis Action Plan (NVHAP) by producing closer to real-time monitoring of implementation of NVHAP, tracking diffusion into vulnerable baby boomer populations of a costly, curative treatment, and developing and implementing tools to understand how factors such as living in a disadvantaged community, discrimination, stigma, poor access, out-of-pocket costs, and depression impede progress toward NVHAP’s goals of addressing racial/ethnic disparities. The study will produce findings about how race and ethnicity influence HCV care, and will identify potential strategies to eradicate HCV among populations facing challenges in maintaining access to care.

PI_NAMEs: SHAPIRO, MARTIN F. (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Address;Affect;Alabama;Anti-viral Therapy;Appointment;Attitude;Awareness;baby boomer;barrier to care;Behavioral Model;Belief;Black Populations;Black race;Caring;Cessation of life;Characteristics;Chronic;Chronic Hepatitis C;cohort;Communicable Diseases;Communities;community collaboration;community partners;contagion;cost;curative treatments;Data;design;Development;Diagnosis;Diffusion;disability;Discrimination;Disease;Disparity;Disparity in diagnosis;Drug usage;Effectiveness;Eligibility Determination;end stage liver disease;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;experience;Family;Feedback;Focus Groups;Gastroenterologist;Gastroenterology;Goals;HCV screening;Health;Health behavior;health care disparity;Health Personnel;Health Services Accessibility;Healthcare;Hepatitis C;Hepatitis C Antiviral;Hepatitis C Therapy;Hepatitis C virus;Hepatology;Hispanic;HIV;Individual;Infection;Injecting drug user;innovation;instrument;insurance claims;Intervention;Knowledge;Licensing;Link;Malignant neoplasm of liver;Measures;Medicaid;medical specialties;Medicine;Mental Depression;Mental disorders;Mental Health;Methods;mortality;neighborhood disadvantage;New York;Newly Diagnosed;novel;opioid misuse;Patients;Pattern;payment;perceived discrimination;Persons;Pharmaceutical Preparations;Phase;Physicians;Population;Primary Care;primary care provider;Progressive Disease;Provider;provider behavior;provider factors;Public Health Administration;public health insurance;Race;racial disparity;racial minority;real time monitoring;Recommendation;Reporting;Research;Research Personnel;RNA;Sampling;screening;Self Efficacy;Shapes;Site;social;social stigma;socioeconomic disparity;Socioeconomic Status;Specialist;Stigmatization;substance misuse;substance use;Surveys;Tablets;Testing;Time;tool;treatment pattern;Treatment Protocols;Trust;Uninsured Medical Expense;Variant;Viral;Viral hepatitis;Vulnerable Populations;Work

PROJECT_TITLE: Disparities in the Diffusion of Direct-Acting Antiviral Therapy for Hepatitis C among Baby Boomers: A Mixed-Methods Study

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Endocrine Disruptors;Mental Health;Neurosciences;Pediatric

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative The first few years of life encompass a period of rapid brain growth and maturation, which is marked by immaturity in the cerebrovasculature and heightened vulnerability to toxicants. Per body weight, children have greater exposure to toxic chemicals than adults, and yet, little is known about the impact of early life toxicant exposures on the developing brain. This study will contribute new information to guide public policy regarding environmental chemicals that, despite their impact on infant development, are common in consumer products.

PI_NAMEs: ENGEL, STEPHANIE  (contact);LIN, WEILI

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: 5 year old;Acceleration;Address;Adult;Age;Area;Attention;Behavior;Behavioral;behavioral outcome;Biometry;Birth;Blood - brain barrier anatomy;Body Weight;boys;Brain;Brain imaging;brain overgrowth;brain volume;Cerebrovascular system;Chemicals;Child;Child Psychiatry;Childhood;Cognition;Cognitive;cognitive function;conduct problem;connectome;consumer product;Development;Dibutyl Phthalate;Diethylhexyl Phthalate;early life exposure;emotional symptom;Enrollment;Ensure;environmental chemical;Environmental Epidemiology;Equipment and supply inventories;Evaluation;Excretory function;executive function;Exhibits;Exposure to;externalizing behavior;frontal lobe;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;high throughput screening;Hyperactivity;imaging biomarker;improved;In Vitro;infancy;Infant;Infant Development;Language Development;language processing;late life;Life;Magnetic Resonance Imaging;Maps;Mass Spectrum Analysis;Measures;Mediator;Metabolism;Motor;neonatal period;neonate;neural;neurobehavioral;neurodevelopment;neurotoxicity;North Carolina;Outcome;Pathway interactions;Pattern;phthalates;Pilot Projects;Plasticizers;Play;Poison;postnatal;prenatal;prenatal exposure;Problem behavior;Public Health;Public Policy;Regulation;Research;Resolution;Resources;Rest;Role;Sample Size;Sampling;Scanning;social;social cognition;spatiotemporal;Structure;Surface;Toddler;Toxic Environmental Substances;toxicant;Toxicant exposure;Toxicology;Universities;Urine;Visit;Visual;welfare;Work;Xenobiotic Metabolism;Xenobiotics

PROJECT_TITLE: Early Life Phthalate Exposures in Relation to Structural and Functional Brain Development

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


NIH_SPENDING_CATS: Kidney Disease;Orphan Drug;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: NARRATIVE The goal of this grant application is to gain a deep understanding of the molecular mechanisms involved in podocyte injury mediated by BRAF signaling, and to harness these insights for the development of much needed, targeted therapies for prevalent forms of FSGS.

PI_NAMEs: GREKA, ANNA  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;Affect;Antioxidants;Applications Grants;autosome;BRAF gene;Cell Death;Cell membrane;Cells;Cessation of life;Chronic Kidney Failure;Clinic;Coenzyme Q10;Data;Development;endoplasmic reticulum stress;Enzymes;Event;FDA approved;Focal and Segmental Glomerulosclerosis;Funding;Gene Expression;Generations;Genetic;Goals;Grant;Human;In Vitro;in vivo;Injury;innovation;insight;Ion Channel;Kidney;Kidney Diseases;Kidney Failure;lipid metabolism;Lipids;loss of function;MAP Kinase Gene;Mediating;metabolomics;Mitochondria;Modeling;Molecular;Mus;Mutation;Nephrotic Syndrome;new therapeutic target;novel;novel therapeutics;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;podocyte;postmitotic;Prevalence;prevent;Proteinuria;Publishing;rare variant;Receptor Signaling;Receptor, Angiotensin, Type 1;Retinoic Acid Receptor;rho GTP-Binding Proteins;Signal Pathway;Signal Transduction;small molecule;Stress;stressor;targeted treatment;Testing;Therapeutic;Tissues;transcriptomics;Up-Regulation;Work

PROJECT_TITLE: Molecular mechanisms of podocyte injury in FSGS

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Stimulant Use and Misuse;Substance Misuse;Women's Health Research

ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Substance use disorder is a significant public health problem. Recent studies demonstrate that females are more vulnerable to the initiation, escalation and withdrawal effects of substance abuse behavior than males. This project will determine the effect of escape from X chromosome inactivation as an epigenetic mechanism on sex differences in addiction.

PI_NAMEs: OGHUMU, STEVE ONYEKA (contact)

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Alleles;Area;Behavior;Bioinformatics;Biometry;brain tissue;Cells;Chronic;Clinical Research;Disease;Disparity;Epigenetic Process;Exposure to;Female;Future;Gene Expression;Gene Modified;Gene Silencing;Genes;Genetic;Goals;Hormonal;in vivo;innovation;knowledge base;Link;male;Modeling;Molecular;Monoamine Oxidase A;mouse model;multidisciplinary;Mus;Nervous System Disorder;Neurons;Neurosciences;novel;novel strategies;Opioid;preclinical study;psychostimulant;Public Health;receptor;Reporter;Research;Research Personnel;sex;Sex Chromosomes;Sex Differences;sex disparity;single-cell RNA sequencing;Substance abuse problem;Substance Use Disorder;Talents;Technology;tool;Visualization;Withdrawal;X Chromosome;X Inactivation

PROJECT_TITLE: X chromosome inactivation in sex disparities to substance use disorder


ORG_CITY: San Diego

ORG_NAME: VIVREON BIOSCIENCES, LLC

PHR: Vivreon Biosciences, LLC 4940 Carroll Canyon Rd. Suite 110  San Diego, CA 92121 milton@vivreonbiosciences.com Vivreon Biosciences, LLC, NCI SBIR Direct to Phase II, Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications, PA-21-259 IND-Enabling Toxicology for VV2003, a Novel CRAC Channel Therapeutic, to Improve Outcomes Associated with Checkpoint Inhibitor Immunotherapy Project Narrative Vivreon Biosciences is conducting investigational new drug (IND)-enabling studies for VV2003, a novel therapeutic to improve outcomes in persons undergoing checkpoint inhibitor immunotherapy. Checkpoint inhibitors have improved overall survival in numerous cancers, but severe diarrhea and enterocolitis side effects limit the effectiveness of these drugs. VV2003 addresses this urgent unmet clinical need through colon-specific immunosuppression, without systemic side effects, by selective blockade of gut-resident inflammatory Ca2+ release activated Ca2+ (CRAC) channels.

PI_NAMEs: GREENBERG, MILTON L (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Abdominal Pain;Address;Animals;Applications Grants;Biological Sciences;Blood;capsule;Cardiovascular system;checkpoint therapy;Chemistry;Clinical;Colitis;Colon;commercialization;cost;design;Development;Diarrhea;Dosage Forms;Dose;Dose Limiting;Effectiveness;Enterocolitis;experience;experimental study;Feces;Fever;Formulation;Funding;gastrointestinal;genotoxicity;Goals;good laboratory practice;gut inflammation;Immune checkpoint inhibitor;immune-related adverse events;Immunosuppression;Immunosuppressive Agents;Immunotherapy;improved;improved outcome;Inflammatory;infliximab;inhibitor;innovation;Investigational Drugs;Investigational New Drug Application;Investigational Therapies;Investments;Malignant neoplasm of lung;Malignant Neoplasms;manufacture;Medical;Metastatic Melanoma;Methods;Minor;Mission;Mucous body substance;novel;novel therapeutics;Oncology;Oral;patient population;Patients;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology and Toxicology;Phase;Process;programs;Property;Regimen;Renal Carcinoma;respiratory;Risk;Running;Safety;safety assessment;safety practice;Secure;side effect;Site;Small Business Innovation Research Grant;small molecule;Steroids;Tablets;Telemetry;Therapeutic;Therapeutic Agents;therapeutic candidate;Therapeutic Effect;Therapeutic immunosuppression;Toxic effect;Toxicogenetics;Toxicology;treatment duration;tumor;United States Food and Drug Administration;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: IND-Enabling Toxicology for a Novel Ca2+ Channel Therapeutic to Improve Outcomes Associated with Checkpoint Inhibitor Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-V(13)B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: Project Narrative Research has demonstrated that parent stress predicts adolescent substance use, but few controlled studies have tested interventions that reduce parent stress to prevent adolescent substance use. The proposed study will use a randomized controlled design to test efficacy and bio-behavioral mechanisms of a parenting-focused mindfulness intervention in reducing parenting stress and parent physiological and neurobiological stress reactivity, improving parenting behavior, and preventing adolescent substance use. Findings will provide evidence for and a mechanistic understanding of an efficient intervention that can decrease parent stress and, at the same time, prevent adolescent substance use disorder risk.

PI_NAMEs: CHAPLIN, TARA M (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: 14 year old;Adolescence;Adolescent;adolescent substance use;Adult;Age;Amygdaloid structure;Anterior;Arousal;Award;Basic Science;behavioral health;biobehavior;Biological;Brain;Brain region;Child Rearing;cingulate cortex;Clinical;Communities;community clinic;Controlled Study;Development;disorder risk;Dorsal;early adolescence;effective intervention;efficacy testing;Emotional;Emotions;Family;Female Adolescents;follow-up;Functional Magnetic Resonance Imaging;Funding;girls;Hydrocortisone;Impairment;improved;innovation;Insula of Reil;Intervention;Interview;Laboratories;Magnetic Resonance Imaging;Measures;Mediating;mindfulness;mindfulness intervention;Mothers;National Institute of Drug Abuse;neurobiological mechanism;Neurobiology;novel;Outcome;Parenting Education;parenting intervention;Parents;Physiological;post intervention;Prefrontal Cortex;prevent;Prevention strategy;Psychopathology;Public Health;Questionnaires;Randomized;randomized controlled design;Randomized, Controlled Trials;recruit;Regulation;Research;response;Rest;Risk;Risk Factors;Sampling;sex;Stimulus;Strategic Planning;Stress;stress reactivity;stress reduction;substance use;Substance Use Disorder;substance use prevention;Symptoms;Teenagers;Testing;Time;Youth

PROJECT_TITLE: Efficacy and Neurobiological Mechanisms of a Parenting-Focused Mindfullness Intervention to Prevent Adolescent Substance Use

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Cardiovascular;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Nanotechnology;Pneumonia and Influenza

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE Respiratory viruses such as influenza cause serious cardiovascular adverse effects in individuals who have poor vascular endothelial cell function. This proposal hypothesizes that circulating sphingosine 1- phosphate that activates endothelial receptors promotes effective host defense and minimizes cardiovascular complications such as blood clots and bleeding. Experiments will define underlying mechanisms and develop new therapeutic strategies to combat cardiovascular complications during respiratory viral infections.

PI_NAMEs: HLA, TIMOTHY TUN (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Adverse effects;Agonist;Albumins;Alveolar;analog;ANGPT1 gene;animal old age;arteriole;Attenuated;beta-arrestin;Binding;Blood coagulation;Blood flow;Blood Platelets;Blood Vessels;Cardiovascular system;career;cell injury;Cell Physiology;Cell Survival;cell transformation;cellular resilience;Chronic;combat;combinatorial;COVID-19 pandemic;cytokine;cytokine release syndrome;Cytoprotection;Data;Dedications;defense response;Dropout;Endothelial Cells;Endothelium;Epoprostenol;experimental study;Fibrosis;Functional disorder;gain of function;Gene Expression;Genetic;Genetic Models;Hemorrhage;High Density Lipoproteins;Homeostasis;Host Defense;Individual;Inflammation;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;influenzavirus;Injury;Knock-out;Laboratories;lipid mediator;loss of function;Lung;lung injury;Mediating;Modeling;Molecular;Molecular Chaperones;mortality;mouse model;Mus;mutant;Names;nanoparticle;NF-kappa B;novel;novel therapeutic intervention;Paracrine Communication;particle;Pathologic;Pericytes;Phosphorylation;prevent;Process;Prostaglandins I;Protective Agents;protective pathway;Pulmonary Inflammation;receptor;Receptor Cell;Recovery;Research;resilience;Resolution;respiratory virus;restraint;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Sphingolipids;sphingosine 1-phosphate;targeted agent;Therapeutic;thromboinflammation;Thrombosis;thrombotic;Transgenic Organisms;Vascular Diseases;Vascular Endothelial Cell;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases;Work

PROJECT_TITLE: Sphingolipid signaling in the endothelium during viral host defense

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Liver Disease;Pediatric;Rare Diseases

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative TReatment for ImmUne Mediated PathopHysiology (TRIUMPH) is a multi-center, three arm, randomized, controlled trial of immunosuppressive therapy for children with acute liver failure. The study will determine if suppressing inflammatory responses with either corticosteroids or equine anti-thymocyte globulin therapy improves survival for children with this rare, life-threatening condition. Developing effective therapy for this disorder would have significant public health impact since mortality in untreated patients exceeds 10% and acute liver failure is one of the most common indications for liver transplantation in children.

PI_NAMEs: ALONSO, ESTELLA M. (contact);DURKALSKI, VALERIE L

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Acceleration;Acute Liver Failure;adaptive immune response;Adrenal Cortex Hormones;Affect;Anti-Inflammatory Agents;Antigen Receptors;Antithymoglobulin;Aplastic Anemia;arm;biobank;Biological Markers;Blood;Blood specimen;Body System;Case Series;Cause of Death;CD8-Positive T-Lymphocytes;Cells;Child;Child health care;Childhood;Circulation;Clinical;Collaborations;Communities;Cytokine Receptors;Data Coordinating Center;Death Rate;design;Diagnosis;Disease;Disease Progression;Dose;Double-Blind Method;Drug toxicity;effective therapy;Effectiveness;efficacy testing;Enrollment;Environmental Exposure;Equilibrium;Equus caballus;Etiology;Evaluation;Event;experience;Functional disorder;functional status;Future;Goals;healing;Health;Hepatic;Hepatocyte;Immune;immune activation;immune function;Immune response;Immunophenotyping;immunoregulation;improved;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Innate Immune Response;Intravenous;Knowledge;Life;Liver;liver biopsy;Liver diseases;liver injury;liver transplantation;Mediating;Methylprednisolone;Minor;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Network Infrastructure;North America;Organ failure;Outcome;Participant;Pathogenesis;Patient Outcomes Assessments;patient subsets;Patients;Pattern;peripheral blood;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Population;Population Analysis;prevent;primary outcome;Process;Prognosis;programs;Public Health;Randomized;randomized placebo controlled trial;Randomized, Controlled Trials;rare condition;Rare Diseases;Rehabilitation therapy;repository;Research;research study;Resolution;Resources;response;Risk;Role;Safety;Sampling;secondary outcome;Severities;side effect;Signal Transduction;Specimen;Steroids;Supportive care;Survival Rate;systemic juvenile idiopathic arthritis;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;theories;Therapeutic immunosuppression;Time;Tissues;Translating;Treatment outcome;treatment trial;Virus;Work

PROJECT_TITLE: Pediatric Acute Liver Failure Immune Response Network (PALF IRN): Treatment for Immune Mediated Pathophysiology (TRIUMPH)


ORG_CITY: BEDFORD

ORG_NAME: EDITH NOURSE  ROGERS MEMORIAL VETERANS HOSPITAL

PHR: PROJECT NARRATIVE Goal 2 of VA's Vision Plan is to "deliver comprehensive and integrated Whole Health care," where a holistic, patient-centered approach is part of all interactions across the healthcare system. However, implementation has been focused in primary and mental healthcare settings, with little attention to specialty care, like HIV clinics. Veterans living with HIV are likely to benefit from a Whole Health approach because of their complex health and social needs. A plan for HIV specialty care implementation is thus needed. We will identify and then work with Veterans with HIV and their HIV providers, as well as leadership, to co-design an implementation blueprint for HIV specialty care. Findings will provide an example of how to provide patient-centered care throughout the VA healthcare system.

PI_NAMEs: FIX, GEMMAE M (contact)

PROJECT_TERMS: Address;Aging;Attention;care coordination;care systems;Caring;Characteristics;Charge;Clinic;Clinical;clinical care;Collaborations;Communicable Diseases;comorbidity;Complex;Data;design;Disease;empowerment;evidence base;experience;Exposure to;Funding;Goals;Health;health care service;health care settings;Health Services;Healthcare;Healthcare Systems;HIV;Home;Homogeneously Staining Region;Hybrids;implementation design;implementation efforts;implementation strategy;innovation;Institutionalization;Interview;Knowledge;Leadership;Learning;marginalization;Medical;medical specialties;member;Mental Health Services;Methodology;Methods;military veteran;Modeling;multidisciplinary;novel;patient oriented;Patient-Centered Care;Patients;Play;Primary Care;primary care team;Primary Health Care;programs;Provider;Recording of previous events;Research;Role;Rural;Sampling;Services;Site;social;social stigma;Stigmatization;Structure;structured data;success;Surveys;System;Testing;Training;training data;United States Department of Veterans Affairs;Variant;Veterans;Veterans Health Administration;Vision;whole health;Work

PROJECT_TITLE: Developing a Blueprint to Implement Whole Health Clinical Care for Veterans with HIV

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Disability Research;Genetics;Hearing Loss;Neurosciences;Pediatric

ORG_DEPT: SURGERY

PHR: Public Health Relevance Statement:  Connexin 26 mutations can induce a high incidence of hearing loss, responsible for >50% of cases of nonsyndromic hearing loss in children. In this proposal, we will investigate detailed cellular and molecular mechanisms underlying Cx26 deficiency induced hearing loss, in particular, mutation-induced pathological changes in the human cochlea. These studies can be expected to have great impact on the understanding underlying deafness mechanisms and are urgently required for developing efficient therapeutic interventions to this most common hereditary hearing loss.

PI_NAMEs: ZHAO, HONG-BO  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Affect;Basilar Membrane;Birth;Cells;Childhood;childhood hearing loss;Clinical;Cochlea;cochlear development;congenital deafness;Connexins;Cytoskeleton;deafness;Development;developmental disease;Diagnosis;Diameter;gap junction channel;Gap Junctions;Gene Expression;gene therapy;Genes;genetic deafness;GJB2 gene;Hair Cells;hearing impairment;hearing restoration;hereditary hearing loss;Human;Impairment;In Situ;Incidence;Induced Mutation;intercellular communication;Knowledge;Laboratories;Lead;Life;Mechanics;Membrane;MicroRNAs;Molecular;mouse model;Mus;Mutation;mutation screening;National Institute on Deafness and Other Communication Disorders;normal hearing;novel;Nucleotides;organ growth;Outer Hair Cells;Pathologic;Pathology;Patients;Permeability;Pillar Cell;preventive intervention;promoter;public health relevance;Recycling;Role;Supporting Cell;Temporal bone structure;Testing;Therapeutic Intervention;transcription factor;Viral

PROJECT_TITLE: Connexin Function and Mechanisms of Cx26 Deficiency Induced Hearing Loss


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The current study seeks to delineate the homeostatic and fibrosis-resolving roles of anti-fibrotic factor CEBPA in lung epithelial cells and to develop a new regenerative therapeutic strategy to treat lung fibrosis in experimental murine models using non-genome editing CRISPR gene activation to promote fibrosis resolution and restore epithelial-mesenchymal homeostasis. The outcomes from proposed studies are expected to have an important positive impact on human chronic lung diseases since identification and application of novel anti- fibrotic regulators will help to overcome current limitations of treating pulmonary fibrosis in human patients.

PI_NAMEs: TAN, QI  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: alveolar epithelium;antagonist;Apoptosis;Attenuated;Bleomycin;BMP4;CEBPA gene;Cell Communication;cell injury;Cell Proliferation;Cells;Chronic lung disease;Cicatrix;Coculture Techniques;CRISPR-mediated transcriptional activation;Cytoprotection;Data;Deposition;Disease;Disease Progression;Epithelial Cells;Epithelium;experimental study;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;gain of function;Gene Expression Profiling;Genes;Genetic Transcription;Goals;Homeostasis;Human;idiopathic pulmonary fibrosis;in vivo;Injury;insight;Knock-out;Link;loss of function;Lung;lung development;lung repair;Mediating;Mediator;Mesenchymal;Mesenchyme;migration;Molecular;mouse model;Mus;Myofibroblast;novel;old mice;Organoids;Outcome;Pathologic;Pathway interactions;Patients;Phenotype;Process;programs;protein expression;Publications;Pulmonary Fibrosis;pulmonary function;Recombinant Proteins;regenerative therapy;repaired;research study;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Sorting;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Transcriptional Regulation;transcriptome sequencing

PROJECT_TITLE: Targeting CEBPA To Restore Epithelial-Mesenchymal Homeostasis In Lung Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Childhood Injury;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Unintentional Childhood Injury

PHR: PROJECT NARRATIVE This community-based participatory research project with Alaska Native tribal organizations seeks to prevent paralytic shellfish poisoning among subsistence harvest communities in Southeast Alaska, through environmental monitoring, modeling, and K12 education.

PI_NAMEs: GRIBBLE, MATTHEW O. (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: Address;Affect;Age;Alaska;Alaska Native;Algae;Area;Awareness;Behavior;Behavioral;Belief;Brazil;Child;China;citizen science;Clams;Communities;community based participatory research;Community Participation;Consumption;cultural competence;Data;Data Collection;Disease;Ecology;Educational Curriculum;Educational Intervention;Educational process of instructing;Educational workshop;elementary school;Elements;Employment;Environmental Monitoring;Evaluation;Freezing;Future;future outbreak;global health;Goals;Grant;Harvest;hazard;health disparity;high risk;high school;High School Student;Human;improved;Indigenous;insight;Intention;interest;Intervention;junior high school;K-12 Education;Laboratories;laboratory equipment;literacy;Location;Measures;member;Mentored Clinical Scientist Development Program;Mexico;Microscopy;model generalizability;Modeling;Molecular;Monitor;Muscarinic Acetylcholine Receptor;Nature;New Zealand;Northern Europe;Not Hispanic or Latino;oceanic research;Oceanography;outreach;Paralysed;Persons;Planning Theory;Poisoning;predictive modeling;prevent;Prevention;Process;programs;Protocols documentation;Public Health;Questionnaires;Recording of previous events;Reporting;Research;Research Project Grants;Resources;Risk;Safety;safety testing;Sampling;Saxitoxin;school district;Science;science education;Seafood;Services;Shapes;Shellfish;skills;skills training;Sodium Channel Blockers;Southern Europe;success;Testing;testing services;Time;Time Series Analysis;tool;toxic algae;Toxic effect;Toxin;Training;training opportunity;tribal Nation;tribal organization;Tribes;Uncertainty;Universities;Visit;web site;Work;Youth

PROJECT_TITLE: Prevention of Paralytic Shellfish Poisoning in Subsistence Shellfish Harvest Communities of Southeast Alaska

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HINES

ORG_NAME: EDWARD HINES JR VA HOSPITAL

PHR: The goal of the Evidence to Policy Evaluation Center for Veterans (EPEC-Vet) is to improve Veteran care and outcomes by conducting rigorous independent evaluations to inform VA policies and programs. These evaluations will address effectiveness, efficiency and sustainability in accordance with the Evidence Act of 2018 (US Public Law 115-435). We will build an infrastructure to support rigorous and timely evaluations by 1. establishing a robust evaluation program to support the planning and conduct of two evaluations per year, 2. Incorporate innovative methods, data collection and/or analytic strategies including developing a set of innovative common evaluation metrics, and 3. employing state-of-the-art knowledge translation methods and use of common evaluation metrics to effectively disseminate results to key VA stakeholders and broader policy and scientific communities.

PI_NAMEs: STROUPE, KEVIN T.;WEAVER, FRANCES M. (contact)

PROJECT_TERMS: Achievement;Address;Affect;Agreement;Area;Budgets;Caring;Centers for Disease Control and Prevention (U.S.);Chicago;Chronic Care;Collaborations;Communication;Communities;Community Healthcare;Complement;Complex;connected care;Contracts;Data;Data Analytics;Data Collection;Databases;design;design and construction;Development;Diffusion;Disease;Dissemination and Implementation;dissemination strategy;economic impact;Effectiveness;Elements;Ensure;Evaluation;evidence base;experience;Feedback;flexibility;Foundations;Generations;Goals;Government Agencies;Health Services;Healthcare;Homelessness;implementation facilitation;implementation framework;implementation strategy;improved;Infrastructure;innovation;knowledge translation;Laws;Leadership;Measures;Methodology;Methods;Modeling;Nursing Services;Office Nursing;operation;Outcome;Patient-Centered Care;pharmacy benefit;Policies;Policy Analysis;Policy Making;pragmatic trial;Principal Investigator;Process;Program Evaluation;programs;prospective;Qualifying;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Seasons;Site;skills;Spinal cord injury;statistics;Translations;United States Department of Veterans Affairs;Universities;Variant;Veterans;Work


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Neurosciences;Rehabilitation;Social Determinants of Health;Stroke

PHR: Project Narrative 795,000 adults who have a stroke annually are vulnerable to reduced social interactions after stroke. This project introduces a new wearable social sensor, SocialBit, that can detect audio signatures of social interactions in real-world settings. In this study, we test whether SocialBit can accurately detect social interactions in stroke patients, which is the crucial first step in reducing social isolation and disability in this population.

PI_NAMEs: DHAND, AMAR  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Adult;Aphasia;Behavior;Behavior Therapy;Binding;Blood Vessels;Caregivers;Cognitive;Cognitive deficits;Communication;Data;Delirium;design;Detection;Ecological momentary assessment;Environment;Exclusion;Future;Growth;Health;Hospitalization;improved;Individual;Inpatients;Intervention;Intervention Trial;Intuition;Language;Language Disorders;Lesion;Life;Location;Loneliness;Measures;Medical;Mental Depression;Methods;Nature;Neurological disability;Outcome;Patient Self-Report;Patients;Personal Satisfaction;Physical Function;Population;post stroke;privacy preservation;prototype;public health priorities;Recovery;recruit;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;sensor;Severities;social;Social Behavior;Social Change;social deprivation;Social disability;Social Interaction;Social isolation;Social Network;Speech;Stroke;stroke outcome;stroke patient;stroke recovery;stroke survivor;Surveys;Synapses;System;Technology;Testing;Time;tool;United States National Institutes of Health;verbal;wearable device;wearable sensor technology

PROJECT_TITLE: SocialBit: Establishing the accuracy of a wearable sensor to detect social interactions after stroke

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Patient Safety

ORG_CITY: EDEN PRAIRIE

ORG_NAME: APLOS MEDICAL INC

PHR: Project NARRATIVE Gastroesophageal reflux disease (GERD) affects millions of Americans. CT Resources has developed a novel device that is an easy and safe surgical option to offer Americans an alternative to current treatments. The device is entering into an early clinical feasibility study to assess performance and safety that will ultimately help to alleviate GERD symptoms and disease progression.

PI_NAMEs: TIHON, CLAUDE NMN (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Adopted;Adverse event;Affect;Amendment;American;Anatomy;Area;arm;Back;Barrett Esophagus;biomaterial compatibility;Chronic Disease;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;commercial application;commercialization;Corrosion;Data;Deglutition;Deglutition Disorders;Dependence;design;Device Safety;Devices;Diagnosis;Disease;Disease Progression;Drug Prescriptions;Drug usage;Enrollment;Esophageal Adenocarcinoma;Esophagitis;Esophagus;experience;Family suidae;Fatigue;Feasibility Studies;feasibility trial;Fibrosis;first-in-human;flexibility;Food;Fundoplication;Gastroenterologist;Gastroesophageal reflux disease;Goals;good laboratory practice;Grant;Health Care Costs;health related quality of life;Hour;Human;Implant;implantable device;improved;Inferior esophageal sphincter structure;innovation;Magnetic Resonance Imaging;Malignant Neoplasms;manufacture;Marketing;meetings;metallicity;Nickel;nitinol;novel;open label;Operative Surgical Procedures;Outcome;pandemic disease;patient safety;Patients;Performance;Persons;Pharmaceutical Preparations;Phase;Physiological;Physiology;preclinical safety;Preparation;pressure;Procedures;Process;prospective;Proton Pump Inhibitors;Quality Control;Quality of life;Recommendation;reduce symptoms;Reflux;Refractory;Report (document);Reporting;Research Personnel;Resistance;Resources;Risk;Safety;safety assessment;safety testing;sample fixation;Shapes;Shoes;Side;side effect;Site;skills;Small Business Innovation Research Grant;Specific qualifier value;Stomach;Stomach Content;Surface;Surgeon;Surgical sutures;Symptoms;Techniques;Testing;Time;Time Study;United States;United States Food and Drug Administration;Validation;Work

PROJECT_TITLE: Clinical Feasibility Study of a Novel Flexible, Non-occlusive GERD Treatment Device


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Comparative Effectiveness Research;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative ACL injuries are common among adolescent athletes, and due to residual muscle weakness and asymmetrical movement and loading patterns, many sustain a second ACL injury following return to unrestricted physical activity. This clinical cohort study seeks to demonstrate that a combination of traditional clinical and novel clinical return to sport measures (including load symmetry) will result in high predictive accuracy for second ACL injuries. The project specifically focuses on assessing the role that novel clinical return to sport measures (load asymmetry, a known risk factor for ACL re-injury) have in predicting second ACL injuries and will result in the development of a clinic based prognostic model that can be used in return to sport decision-making.

PI_NAMEs: QUEEN, ROBIN M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Academy;Address;Adolescent;American;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Behavioral;Bilateral;Caring;Characteristics;Clinic;Clinical;Clinical assessments;clinical care;clinically relevant;Cohort Studies;Consensus;Contralateral;cost;Data;Data Collection;Data Reporting;Decision Making;Development;Equipment;Evaluation;evidence base;Failure;Fright;Future;Goals;graft failure;Guidelines;high risk;improved;Incidence;indexing;Individual;injured;Injury;injury surveillance;innovation;instrument;Intervention;Laboratories;Limb structure;Lower Extremity;Measurement;Measures;Methods;model development;modifiable risk;Motion;Movement;Multicenter Studies;muscle strength;Muscle Weakness;neuromuscular;novel;Observational Study;Orthopedics;Outcome;Patient Self-Report;Patients;Pattern;Performance;Physical activity;Physicians;Play;Postoperative Period;premature;prognostic model;psychologic;Randomized;Readiness;reconstruction;recruit;Rehabilitation therapy;Research;residual limb;Residual state;restoration;return to sport;Risk;Risk Factors;Role;Running;sensor;Shoes;Speed;Sports;standard of care;Surgeon;Testing;Time;Validation;Walking;wearable sensor technology

PROJECT_TITLE: Clinically Assessed Risk Factors for a Second ACL Injury Using an Innovative Wearable Sensor

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Bioengineering;Infectious Diseases;Wound Healing and Care

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE  Microorganisms in biofilms cause a range of human infections and are resistant to most available antibiotics; furthermore, antibiotic resistance, which is heavily influenced by the overuse of antibiotics, is a growing threat to human medicine. To overcome this challenge, we are developing a new “antibiotic-free” way to treat infection, called an “e-bandage,” that will electrochemically generate continuous low concentrations of hydrogen peroxide and/or hypochlorous acid, two antimicrobial/anti-biofilm compounds. We propose to apply this novel strategy to an important medical problem, wound infection; we will design and construct e-bandages and test them in the laboratory and then in animals, with our next step (assuming success), being development of an e-bandage for testing in humans

PI_NAMEs: BEYENAL, HALUK ;PATEL, ROBIN  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acinetobacter baumannii;Acne;Address;Animal Model;Animal Testing;animal tissue;Animals;anti-microbial drug;Antibiotic Resistance;Antibiotics;antimicrobial;Bacteria;Bacterial Infections;Bandage;Biocide;Biology;carbon fiber;Cells;Chemicals;clinic ready;Clinical;clinical practice;Collaborations;Dermal;design;design and construction;Development;Devices;Doctor of Philosophy;dysbiosis;Electrochemistry;Electrodes;Engineering;Ensure;Exhibits;experimental study;Failure;Family suidae;Fibroblasts;flexibility;Foreign Bodies;Funding;Genotype;Genus staphylococcus;Goals;Grant;Host Defense;Human;Hydrogen Peroxide;Hypochlorous Acid;In Vitro;in vitro activity;in vivo;Individual;Infection;innovation;keratinocyte differentiation;Laboratories;Link;Medical;Medicine;Methods;Microbial Biofilms;Microbiology;microorganism;migration;Modeling;Modernization;Mus;novel;novel strategies;novel therapeutics;Orthopedics;Oxygen;prevent;Property;prototype;Pseudomonas aeruginosa;Refractory;Resistance;Safety;Staphylococcus aureus;success;System;Technology;Testing;Textiles;Tissues;Toxic effect;voltage;wound;wound care;wound healing;Wound Infection;wound treatment;Yeasts

PROJECT_TITLE: Novel Electrochemical Bandage for Treatment of Wound Infections

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


PHR: Transgender Veterans (trans Vets) frequently experience gender dysphoria or distress related to discord between their gender identity and birth sex. Gender-affirming treatments (GATs) are medically necessary treatments to reduce gender dysphoria. However, not much is known about the barriers and facilitators that influence GAT access and receipt in VA and VA Community Care (CC), among trans Vets who desire GATs. The goals of this mixed-methods study are to determine which GATs trans Vets receive and in which setting, identify barriers and facilitators associated with desired GAT receipt in VA and CC, how barriers and facilitators influence GAT access and desire, and how to improve GAT access in VA and CC. In partnership with our Stakeholder Advisory Group, we will develop patient-centered implementation strategies to address barriers and enhance facilitators to GAT access. The proposed study will position us to deploy these strategies in a follow-up study to mitigate barriers, improve GAT access in VA and CC, and promote trans health equity.

PI_NAMEs: JASUJA, GUNEET  (contact)

PROJECT_TERMS: Address;Area;Behavioral Model;Birth;Caring;cohort;Collaborations;Communities;Community Healthcare;Competence;cost;Data;Databases;Diagnosis;Discrimination;Distress;effectiveness/implementation study;Ensure;Evidence based treatment;experience;Feeling suicidal;Financial Hardship;follow-up;Follow-Up Studies;Funding;gender affirming therapy;gender dysphoria;gender equity;Gender Identity;Goals;Hair Removal;hazard;Health;health care availability;health care service;health equity;Health Priorities;Health Services Accessibility;hormone therapy;Hormones;housing instability;implementation strategy;improved;innovation;Knowledge;Lesbian Gay Bisexual Transgender Queer;Low income;medically necessary care;Mental Health;Methodology;Methods;nonbinary;novel;Operative Surgical Procedures;Participant;participant interview;patient oriented;Patients;Persons;pharmacy benefit;Positioning Attribute;programs;Prosthesis;Psychotherapy;Quality of life;recruit;reducing suicide;Reporting;Research;Resources;Sampling;Services;sex;Site;social health determinants;Suggestion;suicide mortality;Suicide prevention;Surveys;Time;transgender;Travel;Unemployment;Veterans;Violence;Vulnerable Populations;Work

PROJECT_TITLE: Understanding perceived access and receipt of gender-affirming treatments among transgender Veterans


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: In 2014, a DoD/VA collaboration created the Virtual Hope Box (VHB) mobile app to support suicide prevention. Despite years of investment, the VA does not know if the VHB works and over 90% of high-risk Veterans hospitalized with a recent crisis state they have never heard of it (and even fewer have actually used it). Two VA Medical Centers (Ann Arbor and Puget Sound) will conduct a study of the VHB Enhanced Facilitation (VHB-EF) intervention in which a therapist will help educate Veterans on app purpose for suicide prevention, load the app on their personal phone, practice each app component, discuss strategies to enhance app use, and follow-up after hospital discharge to check-in and support VHB use. This study aims to examine the VHB- EF’s effect on suicide attempts using a randomized controlled trial and explore facilitators and barriers for future implementation of the VHB-EF. Stakeholder input from Veterans and providers (qualitative interviews) will be used to evaluate the VHB-EF and will enable the development of a toolkit for others in the VA to use.

PI_NAMEs: BAGGE, COURTNEY L (contact);REGER, MARK A.

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Adoption;Ambulatory Care;arm;Award;Awareness;Behavior;Behavioral;Caring;Cellular Phone;Clinical;Clinical Practice Guideline;Collaborations;Communities;coping;Data;Department of Defense;depressive symptoms;Development;Education;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation hybrid;Enrollment;evidence base;Evidence based intervention;Feedback;Feeling suicidal;follow up assessment;follow-up;future implementation;General Population;health care service utilization;Hearing;high risk;high risk population;Hospitalization;Hospitals;hybrid type 1 trial;implementation intervention;improved;innovation;inpatient service;Inpatients;Intervention;intervention refinement;Interview;Investments;Knowledge;Location;Measures;Mediating;Mediator;Medical center;member;Mental Health;Methodology;mobile application;Monitor;Outcome;Outpatients;Patients;Persons;Phase;Planning Theory;prevention service;preventive intervention;primary outcome;Provider;Proxy;Randomized;Randomized, Controlled Trials;Recommendation;recruit;reducing suicide;remote delivery;Reporting;Research;Research Priority;Resources;Risk;Role;rural area;Safety;secondary outcome;Self Efficacy;service delivery;Severities;Site;sound;Standardization;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;suicide rate;systematic review;Technology;technology intervention;Telephone;Testing;theories;tool;treatment as usual;treatment guidelines;usual care arm;Veterans;Veterans Health Administration;virtual;virtual assessment;Work

PROJECT_TITLE: Virtual Hope Box Enhanced Facilitation in High-Risk Suicidal Veterans

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


PHR: Emerging antibiotic resistance is a national and global public health crisis that effects veterans and civilians alike. Inappropriate antibiotic use contributes to bacteria developing resistance to these drugs and adverse patient outcomes. The nursing home population is particularly vulnerable to the effects of inappropriate antibiotic use due to their increased susceptibility to infections, high antibiotic use, and increased susceptibility to adverse drug effects, including drug side effects and complications such as Clostridium difficile colitis. Antibiotic choice is guided in part by the patient’s allergy history, with penicillin being the most commonly reported and over-diagnosed allergy leading to unnecessary avoidance of these and related drugs with potentially negative consequences, including increased drug resistance and adverse events. The current project is a crucial first step toward improving evaluation and management of penicillin allergies of veterans in nursing home settings, thereby providing better and safer care for this vulnerable population.

PI_NAMEs: BORZECKI, ANN MARIE (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adverse drug effect;Adverse effects;Adverse event;adverse outcome;Advisory Committees;Affect;Allergic;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Awareness;Bacteria;Belief;care costs;Caring;Clinical;Clinical Pathways;Clinical Pharmacists;community living;Consensus;Consolidated Framework for Implementation Research;contextual factors;design;Development;Diagnosis;Discipline of Nursing;Drug resistance;Drug Side Effects;effectiveness testing;emerging antibiotic resistance;Evaluation;evidence base;Exposure to;Family;Family member;frailty;Future;Geriatrics;Goals;Guidelines;health belief;Health Care Costs;Hospitalization;Hypersensitivity;Hypersensitivity skin testing;implementation strategy;implementation study;improved;improved outcome;Individual;Infection;infection burden;innovation;Inpatients;Instruction;interest;Intervention;Interview;Knowledge;Label;Leadership;Long-Term Care;Methodology;Methods;Modeling;Modification;Nurse Practitioners;Nurses;Nursing Homes;older patient;Oral;Outcome;Outpatients;Pathway interactions;patient oriented;patient safety;Patient-Focused Outcomes;Patients;Penicillin Allergy;Penicillins;Persons;Pharmaceutical Preparations;Pharmacy facility;Physicians;Pilot Projects;Policy Maker;Population;Predisposition;Process Assessment;Provider;Pseudomembranous Colitis;Public Health;Publishing;Recommendation;Recording of previous events;Reporting;residence;Resistance development;Risk;risk perception;Role;Site;Specific qualifier value;Structure;Testing;tool;Treatment Failure;uptake;Veterans;Vulnerable Populations

PROJECT_TITLE: Improving the Evaluation and Management of Penicillin Allergy

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Aging;Genetics;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: NUTRITION

PHR: Project Narrative During aging, protective white adipose in the subcutaneous region decreases whereas pathophysiological white adipose in the visceral region increases. The dysregulation of lipid storage in adipose tissue depots is a driving factor behind many metabolic diseases, such as type II diabetes mellitus, obesity, etc. My proposed research will elucidate the mechanism behind the decrease in subcutaneous adipose tissue to better understand metabolic disease pathogenesis and prime for the development of novel therapeutics.

PI_NAMEs: LIN, FRANCES  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;adipocyte differentiation;Adipocytes;Adipose tissue;Adolescence;Age;aged;Aging;aging related;Area;ATAC-seq;Automobile Driving;Binding;Binding Sites;Biological Assay;Blood Vessels;Cardiovascular Diseases;Categories;Cell Count;Cell Differentiation process;Cell Proliferation;Cell Size;cell type;Cells;ChIP-seq;Chromatin;chromatin remodeling;conditional knockout;cytokine;Defect;Deposition;Development;Disease;Disease Progression;energy balance;Equilibrium;Exhibits;Family;Fatty acid glycerol esters;Fibroblasts;Future;Gene Expression;Generations;Genetic Transcription;Glucose tolerance test;granulocyte;Health;Hematopoietic;Human;Hyperphagia;Hyperplasia;Hypertrophy;Impairment;in vivo;in vivo evaluation;Inflammatory;Inhibition of Cell Proliferation;Insulin Resistance;Knockout Mice;life span;lipid biosynthesis;Lipids;Luciferases;Lymphoid;Macrophage;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolism;Mus;Myelogenous;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Obesity;Organ;Pathogenesis;Pathologic;Population;precursor cell;programs;Proliferating;promoter;Promoter Regions;Proteins;proto-oncogene protein Spi-1;recruit;Reporting;Research;Role;single-cell RNA sequencing;Site;stem cells;Stromal Change;Structure;subcutaneous;T-Lymphocyte;Testing;Therapeutic;Tissues;transcription factor;transcriptome;Visceral

PROJECT_TITLE: Aging-Dependent Changes in Adipose Tissue