NIH_SPENDING_CATS: Cancer;Infectious Diseases

PROJECT_TERMS: 4T1;Acids;Acute;Affect;Allergic;Allergic Disease;Allergic inflammation;aluminum sulfate;Anti-viral Response;Antibody Formation;Asthma;asthma model;Atopic Dermatitis;autocrine;autosome;B-Lymphocytes;Biological Models;Biology;Brain;Breast;Breast Melanoma;CD27 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Collaborations;Complement;Complement Activation;cytokine;Cytokine Activation;Cytokine Receptors;Data;Dendritic Cells;Development;Disease;drug induced liver injury;Epithelial Cells;Epithelium;Event;Family;Genes;Goals;Growth;Hair follicle structure;helminth infection;Human;human disease;IL7 gene;IL7R gene;Immune;Immune response;immune system function;Immunity;Immunization;immunodeficiency;Inflammasome;Inflammation;Influenza;Interleukin 2 Receptor;Interleukin 2 Receptor Gamma;Interleukin-10;Interleukin-13;Interleukin-15;Interleukin-2;interleukin-21;Interleukin-4;Interleukin-9;JAK1 gene;JAK2 gene;Link;Literature;Lung;Lymphocytic choriomeningitis virus;Lymphoid Cell;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Mediating;Memory;methicillin resistant Staphylococcus aureus;microbial;Molecular;mouse model;Mus;Mutate;Mutation;Names;Natural Killer Cells;Neoplasm Metastasis;neoplastic;neutrophil;Papain;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Phosphotransferases;Physiology;Play;Production;programs;Proliferating;Publishing;Pulmonary Inflammation;Pyroglyphidae;Reactive Oxygen Species;receptor;Regulatory T-Lymphocyte;Reporting;response;Retinoids;Role;Sebaceous Glands;Secondary to;Signal Transduction;Skin;Solid Neoplasm;Stat5 protein;Streptococcus pyogenes;Surface;Symbiosis;System;T cell response;T memory cell;T-Cell Development;T-Lymphocyte;Th2 Cells;Therapeutic;Time;TSLP gene;tumor;Virus Diseases;Work;X-Linked Severe Combined Immunodeficiency

PROJECT_TITLE: IL-2 Family Cytokines and their Receptors--Biology of the IL-7/TSLP Systems


ACTIVITY: ZIA

ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Diabetes;Genetics;Neurodegenerative;Neurosciences;Nutrition;Obesity;Pain Research;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MUKOUYAMA, YOH-SUKE  (contact)

PROJECT_TERMS: Address;Adult;Affect;afferent nerve;Afferent Neurons;Anatomy;Animal Model;Arteries;Axon;Binding Proteins;Biology;Blood Vessels;Calcium;calcium indicator;Capsaicin;cell type;Cells;Characteristics;chemokine;Complex;coronary vasculature;CXCR4 gene;CXCR4 Receptors;deep learning;designer receptors exclusively activated by designer drugs;Development;Diameter;diet-induced obesity;Disease;Ear;Embryo;Endothelial Cells;Endothelium;Epidermis;Exhibits;experimental study;Fiber;Fluorescence;Forelimb;Functional disorder;gain of function;Gene Expression Profiling;Genes;Genetic;genetic manipulation;Goals;high resolution imaging;Hypersensitivity;Hypoxia;Image;image processing;imaging modality;imaging system;Impairment;in vivo;inhibitor;insulin signaling;interest;Invaded;Investigation;keratinocyte;Knock-in Mouse;Knock-out;Limb structure;loss of function mutation;Maintenance;Manuscripts;Mediating;Methods;Modeling;Molecular;Morphogenesis;Morphology;mouse model;Mus;Mutation;Nerve;nerve supply;Nervous System;Neuropathy;neurovascular;neutralizing antibody;Nociceptors;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Obesity;Organ;Organ Culture Techniques;Oxygen;pain behavior;Pain Measurement;painful neuropathy;Pathologic;Pathway interactions;Pattern;peripheral blood vessel;Peripheral Nerves;Phenotype;Phosphatidylinositols;PIK3CG gene;Prediabetes syndrome;Preparation;programs;promoter;receptor;recruit;Reporting;Research;Resolution;response;Role;Sensory;Signal Transduction;Skin;Smooth Muscle Myocytes;stem cells;Stromal Cell-Derived Factor 1;Time;Tissues;tool;transcription factor;TRPV1 gene;Tumor Suppressor Proteins;Up-Regulation;Vascular Smooth Muscle;Vascular System;Visualization;wortmannin

PROJECT_TITLE: The study of stem cell and neuro-vascular development


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PI_NAMEs: ZHAO, KEJI  (contact)

PROJECT_TERMS: 3-Dimensional;Active Sites;Acute;Address;Animals;Architecture;ATP phosphohydrolase;Auxins;Bar Codes;Binding;Biological;Biological Assay;Biological Models;CCL4 gene;CD4 Positive T Lymphocytes;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Loop;chromatin modification;cohesin;Complex;cost;Data;Data Set;Deoxyribonuclease I;Deoxyribonucleases;Development;Disease;DNA;DNA Methylation;DNase I hypersensitive sites sequencing;Elements;embryonic stem cell;Enhancers;Enzymes;EP300 gene;Epigenetic Process;epigenome;epigenomics;experimental study;gene conservation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genome;genome-wide;genome-wide analysis;genomic locus;genomic profiling;Genomics;Goals;Heterochromatin;Heterogeneity;Hi-C;histone modification;host cell factor C1;Human;Hypersensitivity;in vivo;indexing;interest;Knock-in;Leukocytes;Ligation;magnetic beads;Malignant Neoplasms;Maps;Mediating;Memory;Methods;Micrococcal nuclease digestion of chromatin followed by sequencing;Modality;Mouse Embryonic Stem Cells;Mus;Mutation;Names;Nature;novel;Nucleic Acid Regulatory Sequences;Nucleosomes;Pathologic;Play;Population;Positioning Attribute;Production;promoter;Property;Proteins;Regulatory Element;Resolution;RNA;RNA Polymerase II;Role;Sampling;Signal Transduction;single cell ATAC-seq;single molecule;Site;SMARCA4 gene;Structure;System;T4 DNA Ligase;Techniques;Technology;Three-dimensional analysis;tool;transcription factor;Transcription Initiation Site;Transcriptional Regulation;Transferase;Undifferentiated;Variant;Visualization

PROJECT_TITLE: Genome-wide analysis of chromatin modifications


NIH_SPENDING_CATS: Aging;Asthma;Bioengineering;Biotechnology;Cardiovascular;Chronic Obstructive Pulmonary Disease;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Hypertension;Lung;Precision Medicine;Prevention

PI_NAMEs: LEVY, DANIEL  (contact)

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Aging;Airway Disease;Alleles;Alternative Splicing;Animals;Anti-Inflammatory Agents;Area;Asthma;asthmatic patient;Atherosclerosis;biobank;Biological Markers;Biology;biomarker identification;biomarker panel;biomarker signature;Blood;Blood Pressure;blood pressure regulation;Bronchoalveolar Lavage Fluid;C-reactive protein;candidate identification;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;clinical epidemiology;Cloud Computing;comorbidity;Complex;Computational Biology;Coronary heart disease;Data;Data Analyses;data exchange;Data Set;database of Genotypes and Phenotypes;Diabetes Mellitus;diagnostic biomarker;Dimensions;disability;Disease;disorder risk;DNA Methylation;DNA sequencing;early detection biomarkers;Engineering;Environmental Pollutants;environmental tobacco smoke exposure;Epigenetic Process;Fibrinogen;Forced expiratory volume function;Framingham Heart Study;Functional disorder;Genes;Genetic;genetic epidemiology;Genetic Predisposition to Disease;genome-wide;Genomic approach;Genomics;Genotype;Goals;Heart;Heart failure;Histopathology;Human;Hypertension;hypertension treatment;improved;Individual;Infection;Inflammation;Inflammatory;insight;Interstitial Lung Diseases;Intervention;Intramural Research;Knowledge;Laboratories;lipid disorder;Lung;Lung Capacity;Lung Diseases;lung volume;Malignant Neoplasms;Manuscripts;Mathematical Computing;Measures;Mendelian randomization;Metabolic syndrome;Methods;Mission;Molecular;mortality;Mus;National Heart, Lung, and Blood Institute;Nature;novel;Obesity;Paper;Participant;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Plasma;Plasma Proteins;Population;Population Sciences;Population Study;pre-clinical;predictive marker;premature;prevent;Prevention;Prevention strategy;Process;programs;Property;protein biomarkers;Proteins;Proteomics;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Pulmonary Sarcoidosis;Pulmonary Surfactant-Associated Protein D;Quantitative Trait Loci;receptor for advanced glycation endproducts;Research;Research Personnel;Resources;Respiration Disorders;respiratory;Respiratory Disease;Risk Assessment;Risk Factors;risk stratification;Role;Science;screening;Secretory Cell;secretory protein;Smoking;Spirometry;Statistical Computing;Stroke;Structure;Systems Biology;Testing;therapeutic target;Time;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Vital capacity;whole genome;Work;working group

PROJECT_TITLE: Framingham Project/Levy


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Cancer;Clinical Research;Cooley's Anemia;Genetics;Hematology;Immunotherapy;Lung;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: TISDALE, JOHN  (contact)

PROJECT_TERMS: Ablation;Acute;Acute Graft Versus Host Disease;Adult;Age;Allogeneic Bone Marrow Transplantation;Allogenic;allograft rejection;Allografting;Amendment;Animal Model;Antibodies;Blood;CD3 Antigens;Child;Chimerism;chronic graft versus host disease;clinical application;Clinical Protocols;Clinical Trials;comorbidity;conditioning;Cross-Sectional Studies;curative treatments;Cyclosporine;Data Analyses;design;Disease;Disease-Free Survival;Disseminated Malignant Neoplasm;Dose;Engraftment;follow-up;Frequencies;Gene Transfer;Genes;Genotype;Globin;Goals;graft vs host disease;heart function;Hematological Disease;Hematopoiesis;Hematopoietic;hematopoietic engraftment;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Heterozygote;Human;hydroxyurea;Immune response;Immunosuppression;improved;Individual;Institutional Review Boards;Investigation;irradiation;Life Expectancy;Lung Diseases;Marrow;Mathematics;Measures;Mendelian disorder;Modeling;mortality;mouse model;Mus;Neurocognitive;Neuropsychological Tests;Non-Malignant;Organ;Organ failure;Outcome Measure;Pain;Patients;peripheral blood;Peripheral Blood Stem Cell;Phenotype;Production;programs;Prospective Studies;Proto-Oncogene Protein c-kit;Protocols documentation;Publishing;pulmonary function;Quality of life;Regimen;Renal function;Reporting;Risk;safety and feasibility;Second Primary Cancers;secondary analysis;secondary endpoint;secondary outcome;Severities;Siblings;Sickle Cell Anemia;Sickle Cell Trait;Signal Transduction;Sirolimus;Source;Stem Cell Mobilization;Stroke;Supportive care;synergism;T-Lymphocyte;Testing;Thalassemia;Time;Toxic effect;Transplant Recipients;Transplantation;vaso-occlusive crisis

PROJECT_TITLE: Nonmyeloablative allogeneic PBSC in globin disorders


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Cooley's Anemia;Gene Therapy;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: absorption;Address;Anemia;Animal Experimentation;Animal Model;Animals;Antibody-drug conjugates;Autologous;B-Lymphocytes;beta Globin;beta Thalassemia;Biological Models;Biotin;Bone Marrow Transplantation;Busulfan;Capsid;Cells;cellular transduction;chemotherapeutic agent;Clinical;clinical application;clinical development;Clinical Research;Clinical Trials;clinically relevant;Clonal Hematopoietic Stem Cell;Communication;conditioning;cross reactivity;Disease;dosage;Dose;Drug Kinetics;endonuclease;Engraftment;Enhancers;Erythrocytes;Erythroid;Fetal Hemoglobin;Formulation;Gene Expression;gene therapy;Gene Transfer;Gene Transfer Techniques;gene transfer vector;gene-editing approach;Genes;genetic manipulation;genetically modified cells;Globin;Hematopoiesis;Hematopoietic stem cells;Hemoglobinopathies;HIV;Homologous Transplantation;Human;human model;improved;in vivo;in vivo Model;individual patient;Infusion procedures;Insertional Mutagenesis;integration site;Intravenous;irradiation;Journals;Label;lentiviral-mediated;Lentivirus Vector;life span;Macaca mulatta;Manuscripts;Marrow;mathematical model;Measures;Medicine;Methods;Modeling;Monitor;mouse model;Myelogenous;Myelosuppression;Nature;neutrophil;New England;nonhuman primate;Oral;peripheral blood;Peripheral Blood Stem Cell;Phenotype;Phylogenetic Analysis;Plasmids;Population;Pre-Clinical Model;preclinical development;preclinical study;Preclinical Testing;Production;promoter;Publishing;Reagent;Regulatory Element;Reporter;Reporting;Retroviral Vector;Rhesus;Risk Assessment;Rodent Model;Series;Sickle Cell;Sickle Cell Anemia;sickling;Single-Gene Defect;SIV;Source;stem cell genes;stem cells;success;T-Lymphocyte;technique development;Technology Transfer;Testing;Thalassemia;transduction efficiency;transgene expression;Transplantation;vector;Viral Vector;Whole-Body Irradiation;Work

PROJECT_TITLE: Preclinical and Clinical Studies in Gene Therapy for Sickle Cell Disease


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: Affect;Benign;beta Globin;Biological Assay;Blood;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;CD34 Antigens;CD34 gene;Cell Lineage;Cells;Clinic;clinical application;clinical practice;Clinical Trials;Disease;Elements;Engraftment;Erythroid;fitness;Gene Transfer;gene-editing approach;Genes;Genetic;Genetic Diseases;genome editing;Globin;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Human;human disease;insight;Lentivirus Vector;Life;Malignant - descriptor;Methodology;Modeling;Modification;Population;Positioning Attribute;postnatal;Reagent;Series;Sickle Cell Anemia;Source;stem cell engraftment;stem cell therapy;stem cells;System;Techniques;Testing;therapeutic gene;Time;tool;transduction efficiency;Transplantation;vector;Viral Vector;Xenograft Model

PROJECT_TITLE: Isolation, characterization, and transplantation of candidate stem cells


NIH_SPENDING_CATS: Genetics;Human Genome;Immunotherapy;Infectious Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: adaptive immune response;Affect;Asthma;Autoimmunity;Bacterial Infections;Binding;Binding Sites;Biological Process;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Lineage;Cells;ChIP-seq;Chromatin;Chromatin Loop;Chromatin Structure;Collaborations;Complex;cytokine;Cytokine Gene;Data;Dendritic Cells;Deposition;Development;Distant;Elements;Enhancers;Ensure;Enzymes;Epigenetic Process;epigenetic profiling;epigenetic regulation;epigenomics;Family;FOXP3 gene;GATA3 gene;Gene Expression;Genes;Genetic Transcription;genome-wide;genomic locus;Helper-Inducer T-Lymphocyte;Hematopoietic stem cells;Heritability;histone modification;Human;Hypersensitivity;IFNG gene;Immune;Immune system;Immune System Diseases;immune system function;Immunologic Memory;Immunology;Innate Immune Response;insight;interest;Interferon Type II;Interferons;Locus Control Region;Lymphoid;Lymphoid Cell;mammalian genome;Mammals;Memory;Methods;Methylation;Micrococcal nuclease digestion of chromatin followed by sequencing;Modeling;Modification;Multipotent Stem Cells;Natural Killer Cells;Nature;Nucleic Acid Regulatory Sequences;Nucleosomes;pathogen;Pathogenesis;Pathologic;Phase;Play;Population Heterogeneity;prevent;progenitor;programs;promoter;Regulatory Element;Regulatory T-Lymphocyte;Reporting;Repression;response;Rest;restraint;Role;Site;stem cells;Structure;T cell differentiation;T cell response;T memory cell;T-bet protein;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Techniques;Th2 Cells;Thymus Gland;Trans-Activators;Transcript;transcription factor;Transcription Factor AP-1;Untranslated RNA;Viral

PROJECT_TITLE: Epigenetic Regulation of T cell differentiation


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Acceleration;Address;Affect;ATP phosphohydrolase;B-Lymphocytes;beta catenin;Binding;Body Regions;Cell Differentiation process;Cells;Chromatin;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Collaborations;Complex;Data;Data Set;demethylation;Deposition;derepression;Development;Developmental Gene;Disease;Dissociation;DNA;DNA Sequence;Dominant-Negative Mutation;Elements;Embryo;embryonic stem cell;Enhancers;Epigenetic Process;epigenetic regulation;epigenomics;Epitopes;GATA3 gene;Genes;Genetic Transcription;Genome;genome-wide;Goals;gut homeostasis;gut inflammation;gut-liver axis;Hematopoietic stem cells;Hepatectomy;Heterochromatin;Heterozygote;Hi-C;Higher Order Chromatin Structure;Histone H3;histone methylation;histone modification;Histone-Lysine N-Methyltransferase;Histones;Immunity;Immunology;Induced Mutation;inhibitor;insight;Intestines;KDM1A gene;KDM5B gene;knock-down;Laboratories;LIF gene;Liver;Love;Lymphoid;Lysine;Maintenance;Malignant Neoplasms;Measures;Mediating;Methylation;microbial;Micrococcal nuclease digestion of chromatin followed by sequencing;Missense Mutation;Modification;Mouse Embryonic Stem Cells;mutant;Mutation;Nature;Nervous System Disorder;Nucleic Acid Regulatory Sequences;Nucleosomes;Oncogenic;Pattern;Physiology;pigment epithelium-derived factor;Play;pluripotency;Polycomb;Positioning Attribute;PPAR alpha;Production;progenitor;promoter;Proteins;Proteomics;Regulation;Repression;Residencies;restraint;Role;self-renewal;Signal Pathway;Signal Transduction;Site;SMARCA4 gene;Source;stem;stem cell differentiation;stem cell function;stem cell proliferation;stem cells;Surface;SWI/SNF Family Complex;System;TCF Transcription Factor;Techniques;Tetanus Helper Peptide;tissue repair;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptomics;tumorigenesis;Variant

PROJECT_TITLE: Epigenetic Regulation of Embryonic and Hematopoietic Stem Cells


PI_NAMEs: LEDERMAN, ROBERT J (contact)

PROJECT_TERMS: Agreement;Cardiovascular system;Caring;Catheterization;Catheters;Collaborations;Dangerousness;Development;Devices;Electrocardiogram;Environment;experimental study;Heating;hemodynamics;Human;Human Subject Research;Image;Industry;interest;Intervention;Iron;Laboratories;Magnetic Resonance Imaging;magnetohydrodynamic;Medical;metallicity;Monitor;novel;Performance;Predisposition;preservation;Property;research and development;Research Personnel;Roentgen Rays;safe patient;Safety;System;technology development;Time;Tissues;tool;Translations;United States National Institutes of Health

PROJECT_TITLE: MRI cardiovascular catheterization technology development


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Congenital Heart Disease;Heart Disease;Pediatric;Rare Diseases

PROJECT_TERMS: Ablation;Address;Adopted;Animals;Aorta;aortic valve;aortic valve replacement;artery occlusion;Bioprosthesis device;Cardiomyopathies;Catheters;Clinical;Clip;congenital heart abnormality;Coronary artery;design;Devices;Disease;Electrocardiogram;Electrosurgery;Enrollment;Future;Heart;Heart failure;Hypertrophic Cardiomyopathy;Implant;implantation;improved;Industry;industry partner;interstitial;Laboratories;Laceration;Left;Left Ventricular Function;Life;Mediation;Medicine;Mitral Valve;Modeling;Multi-Institutional Clinical Trial;Myocardial;Myocardium;novel;novel strategies;Obstruction;Patient Care;Patients;preclinical development;preservation;prevent;Procedures;Psychological reinforcement;Pump;research clinical testing;Slice;structural heart disease;Techniques;Technology;Testing;Tricuspid Valve Insufficiency;Universities;Ventricular;Ventricular Arrhythmia;ventricular hypertrophy;Ventricular Remodeling;Ventricular Tachycardia

PROJECT_TITLE: Novel catheter treatment of structural heart and valve disease


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

PROJECT_TERMS: Ablation;Agreement;Anatomy;Aorta;aortic valve;aortic valve replacement;Arteries;Businesses;Bypass;Cardiomyopathies;Catheters;Clinical;congenital heart abnormality;Dedications;design;Devices;Electrosurgery;Forcep;Goals;Heart;Heart Atrium;Heart failure;high risk;Implant;Industry;Intervention;invention;Laboratories;Legal patent;Life;Magnetic Resonance Imaging;Medical Device;Mitral Valve;Myocardial;myocardial biopsy;Myocardium;Needles;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Pathway interactions;Patient Care;Patients;Private Sector;Procedures;prototype;repaired;Research;research and development;research clinical testing;Research Contracts;Roentgen Rays;Slice;Small Business Innovation Research Grant;Technology;tool;Translating;Tricuspid valve structure;Work

PROJECT_TITLE: MRI and X-ray catheter design and prototyping


NIH_SPENDING_CATS: Nutrition

PI_NAMEs: SACK, MICHAEL  (contact)

PROJECT_TERMS: Adaptive Immune System;Asthma;Atopic Dermatitis;Biology;Cells;Degenerative Disorder;detection of nutrient;dietary;dietary restriction;Disease;disease model;effector T cell;Enzymes;Homeostasis;Immune;immune function;immunoregulation;Inflammatory;Influenza;Innate Immune System;interest;Intervention;Laboratories;Link;Liver;Macrophage;monocyte;Mus;Organ;Organelles;Process;Protocols documentation;resilience;Role;Signal Transduction;Tissues;Work

PROJECT_TITLE: Role of intracellular organelle homeostasis in adaptation to dietary restrictive interventions


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

PI_NAMEs: SELLERS, JAMES  (contact)

PROJECT_TITLE: Studies of Drosophila Myosins


NIH_SPENDING_CATS: Cardiovascular;Physical Activity

PI_NAMEs: HWANG, PAUL M. (contact)

PROJECT_TITLE: Redox and other mechanistic insights into cancer and cardiovascular diseases


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung

PI_NAMEs: LEVINE, STEWART  (contact)

PROJECT_TERMS: Acute;adaptive immune response;adaptive immunity;Adoptive Transfer;Airway Disease;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergic;allergic airway inflammation;Alveolar Macrophages;Apolipoprotein A-I;Apolipoprotein E;Apolipoproteins;Asthma;asthmatic;ATP binding cassette transporter 1;Attenuated;Binding;Bronchoalveolar Lavage Fluid;Caring;Cell Physiology;Cells;Clinical Immunology;cytokine;Dendritic Cells;Dermatophagoides Antigens;Development;eosinophil;Epithelial Cells;Extrinsic asthma;Genes;Goals;Goblet Cells;Granulocyte Colony-Stimulating Factor;Heterogeneity;Human;Hyperplasia;Hypersensitivity;Immunology;Inflammation;Inflammatory;insight;Interferons;Intranasal Administration;ITGAM gene;ITGAX gene;Journals;Knockout Mice;LCN2 gene;Ligands;Low Density Lipoprotein Receptor;Lung;lung microvascular endothelial cells;Macrophage;Mediating;Metaplasia;Modification;Mucous body substance;Mus;Myelogenous;neutrophil;new therapeutic target;novel;Ovalbumin;Pathogenesis;Pathway interactions;Pharmaceutical Preparations;Physiologic pulse;Play;Printing;Production;Publishing;Pyroglyphidae;receptor;receptor binding;recruit;Research;Role;single-cell RNA sequencing;TLR4 gene;uptake;VLDL receptor;Wild Type Mouse

PROJECT_TITLE: Characterizing the Role of Apolipoprotein Receptors in Asthma Pathogenesis


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PI_NAMEs: MURPHY, ELIZABETH  (contact)

PROJECT_TERMS: Acute;Adult;Brain Hypoxia-Ischemia;C-terminal;Cardiac Myocytes;cardioprotection;Cardiovascular Diseases;Cardiovascular Physiology;Cause of Death;Cell Death;Cell Death Induction;Cell Physiology;Cells;Complex;Crista ampullaris;Cyclic GMP;cyclophilin D;Cysteine;cytochrome c;Data;Fibroblasts;Goals;Heart;Heart Diseases;heart function;Hydrogen Peroxide;Hydrophobicity;Intervention;Ischemia;Ischemic Preconditioning;Mediating;Mitochondria;Mitochondrial Proteins;Modification;Molecular Weight;Mus;Mutate;Mutation;Myocardial Ischemia;Nitric Oxide;nitrogen trioxide;novel therapeutics;OPA1 gene;Organ;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Oxygen;palmitoylation;Pathway interactions;Perfusion;Play;Post-Translational Protein Processing;prevent;Process;protein function;Protein S;protein structure;Proteins;Proteomics;Reactive Oxygen Species;Regulation;Reperfusion Therapy;Role;S-Nitrosoglutathione;SKIL gene;Sulfhydryl Compounds;Transition Elements

PROJECT_TITLE: Role of S-nitrosylation in regulating cardiac function and disease


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

PI_NAMEs: DUNBAR, CYNTHIA E (contact)

PROJECT_TERMS: Adult;Allogenic;Animal Model;Animals;Arrhythmia;Autologous;Biological Assay;Biology;Cardiac;Cardiac Myocytes;CD19 gene;CD34 gene;Cell Differentiation process;Cell Therapy;cell type;Cells;Chronic;Clinical;clinical development;Clone Cells;Collaborations;Country;CRISPR/Cas technology;Derivation procedure;Detection;Development;Disease;Ectoderm Cell;Ectopic Expression;Electrophysiology (science);Endoderm Cell;Engraftment;Ensure;Euthanasia;Excision;experimental study;Exposure to;Fibroblasts;gene therapy;Genes;Genetic;Genetic Markers;Germ Layers;Goals;Health;Heart;heart rhythm;Hematopoietic;Histology;Homing;Human;human induced pluripotent stem cells;Image;Immune response;Immunodeficient Mouse;Implant;improved;in vitro Model;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Infarction;Inflammatory Response;intercalation;Investigation;Iodides;Life;Macaca;Macaca mulatta;Magnetic Resonance Imaging;Marrow;Mediating;Medical;Mesoderm Cell;Modeling;mouse model;Mouse Strains;Mus;Mutation;Myocardial Infarction;Myocardium;National Heart, Lung, and Blood Institute;nonhuman primate;novel;PET/CT scan;Phenotype;Physiological;pluripotency;postnatal;Pre-Clinical Model;preclinical development;prevent;Procedures;Property;Protocols documentation;Publications;Publishing;regenerative;Regenerative Medicine;Reporting;Research Personnel;Residual state;Resources;Rhesus;Safety;safety assessment;Signal Transduction;Skin;SLC5A5 gene;Somatic Cell;stem cell fate specification;stem cells;Stromal Cells;System;Teratoma;Therapeutic;Time;Tissues;tool;Tracer;transcription factor;Transplantation;tumor;United States National Institutes of Health;vector;Work;Xenograft procedure

PROJECT_TITLE: Macaque models for preclinical development of iPSCs


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Immunotherapy;Infectious Diseases;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Aging;Alzheimer's Disease;Antibodies;ATAC-seq;Autologous;B-Lymphocytes;Bar Codes;Base Pairing;Behavior;Big Data Methods;Blood;Blood donor;Brain;Busulfan;CD34 gene;Cell Lineage;Cell Ontogeny;Cell Therapy;Cells;Central Nervous System Diseases;Characteristics;chemokine;chimeric antigen receptor T cells;Clinical;clinically relevant;Clonality;Clone Cells;Collaborations;conditioning;Cues;Cytomegalovirus;Cytomegalovirus Infections;cytotoxic;Data;Development;differential expression;Disease;Donor person;engineered NK cell;Engineering;Engraftment;Environment;Epigenetic Process;experimental study;FCGR3B gene;fighting;Gene Expression;Gene Expression Profile;gene therapy;gene-targeted therapy;Generations;Genes;Genetic;genetic manipulation;Goals;Growth;Hematopoiesis;Hematopoietic;hematopoietic engraftment;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homing;Human;Image;Immune;Immunology;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;Individual;Infection;insight;Interleukin-15;Investigation;Knowledge;Laboratories;Lentivirus Vector;life history;Link;Liver;Lung;Macaca;Macaca mulatta;Macrophage;Maintenance;Malignant Neoplasms;Mediating;Memory;Methodology;Methods;Microglia;Minor;Modeling;Molecular;Monkeys;mouse model;Mus;Myeloid Cells;Natural Killer Cells;NCAM1 gene;nonhuman primate;novel;novel strategies;Organ;Output;Pattern;Phenotype;Plasma Cells;Population;Positioning Attribute;post-transplant;Primates;Process;Protein Secretion;Reaction;receptor;recruit;Regimen;Reproducibility;Residual state;response;Retrieval;segregation;self-renewal;single-cell RNA sequencing;SLC5A5 gene;Sorting;Spleen;stem cell engraftment;Surface;Techniques;Testing;Time;Tissues;trafficking;Transgenes;Transplantation;tumor;Vaccination;vector;Viral;Virus Diseases;Waxes;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Clonal and imaging analyses of in vivo hematopoiesis, immune cell ontogeny and adoptive cell therapies


PI_NAMEs: TJANDRA, NICO  (contact)

PROJECT_TERMS: Address;Adopted;alpha helix;Amyloid beta-Protein;Antibodies;Apoptosis;Apoptotic;Area;Bax protein;BCL-2 Protein;BCL2 gene;BCL2L1 gene;Binding;biophysical techniques;C-terminal;Cell Death;Cell Physiology;Cell Survival;Cells;Cellular Assay;Classification;Collaborations;Complex;confocal imaging;Coupling;crosslink;Cryoelectron Microscopy;Cytoplasm;Cytosol;Data;design;Detergents;electric field;Electrons;environmental change;expectation;Family;Fiber;Fluorescence Resonance Energy Transfer;fluorophore;Goals;Gold;Heterogeneity;human disease;humanin;Hybrids;Hydrophobicity;in vivo Model;Inhibition of Apoptosis;interdisciplinary approach;interest;Label;Lanthanoid Series Elements;Length;Location;Measurement;Measures;member;Membrane;Methodology;Methods;Micelles;Mitochondria;mitochondrial membrane;Molecular;Molecular Conformation;Morphology;mutant;Neurons;neuroprotection;new technology;Nuclear Magnetic Resonance;Outer Mitochondrial Membrane;Patients;Peptides;Permeability;Physiologic pulse;Physiological;Play;prevent;Property;Protein Family;protein oligomer;protein structure;Proteins;Protocols documentation;reaction rate;Regulation;Relaxation;Research;Residual state;Scheme;Series;Signal Transduction;Site;Structure;Targeted Research;targeted treatment;Testing;therapeutic development;three dimensional structure;Time;two-dimensional;Variant;Vesicle

PROJECT_TITLE: Regulation of mitochondria morphology


PI_NAMEs: KNUTSON, JAY R (contact)

PROJECT_TERMS: absorption;Binding;Binding Proteins;cancer cell;Cancer Cell Growth;Cell Nucleus;Cells;Chromatin;cofactor;Collaborations;Collection;Color;Correlative Study;Dendrimers;Detection;Development;Device or Instrument Development;Devices;DNA;Dyes;Environment;Equilibrium;flexibility;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescent Dyes;Glycolysis;Hypoxia;Image;improved;intravital imaging;Label;Light;light emission;macromolecule;Measurement;Measures;Metabolic;Metabolism;Methods;Microscope;Mitochondria;Molecular Conformation;multi-photon;multiphoton microscopy;Muscle Cells;NADH;nanosecond;neoplastic cell;Normal Cell;Organelles;Oxidation-Reduction;Oxygen;Oxygen Consumption;Paclitaxel;Photons;Proteins;Publishing;quantitative imaging;Reactive Oxygen Species;Resolution;Shapes;Signal Transduction;Sorting;Spectrum Analysis;Spottings;submicron;Testing;Time;Tissues;tool;transcription factor;Transfection;two-photon;Water;Work

PROJECT_TITLE: Multiphoton Microscopy Development


NIH_SPENDING_CATS: Bioengineering

PROJECT_TITLE: Optical Superresolution Microscopy (Nanoscopy)


PROJECT_TERMS: aptamer;Binding Sites;Biological Assay;Biological Products;Biotechnology;Cells;Collaborations;Communication;Coupling;design;Detection;detection assay;Development;dimer;Disease;DNA;DNA Probes;DNA-Binding Proteins;Drops;Dyes;experience;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescence Spectroscopy;Genetic Polymorphism;Heterogeneity;Industry;Knowledge;Metals;Molecular Structure;nanoassay;nanocomposite;nanomolar;nanoparticle;Nanoscopy;Optics;Organelles;Organism;Peptides;Proteins;quantum optics;rapid test;Reporting;RNA;RNA Probes;Site;System;Techniques;Time;ultra high resolution

PROJECT_TITLE: Nanoassay development


NIH_SPENDING_CATS: Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases

PI_NAMEs: PUERTOLLANO-MORO, ROSA  (contact)

PROJECT_TERMS: Address;Agonist;Animals;Antigen Presentation;Arsenites;Autophagosome;Bacteria;Binding;biological adaptation to stress;Calcium;Cations;CCL2 gene;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Cessation of life;chemokine;Cholesterol;Cholesterol Homeostasis;Collaborations;Color;Complex;Data;Defect;deprivation;Dominant-Negative Mutation;Dynein ATPase;Early Endosome;Embryo;Endosomes;Epidermal Growth Factor Receptor;Event;Family;Family member;follow-up;Follow-Up Studies;gain of function mutation;Ganglioside Sialidase Deficiency Disease;Genes;Genetic Transcription;genome wide association study;Germany;hearing impairment;Homeostasis;human disease;Human Pathology;Immune response;Immunofluorescence Immunologic;Impairment;In Vitro;in vivo;Injections;Innate Immune Response;Integral Membrane Protein;interest;Invaded;Ions;Kidney;knock-down;Knock-out;Knockout Mice;Laboratories;late endosome;Ligands;Link;lymphoid organ;Lysosomal Storage Diseases;Lysosomes;Macrophage;Magnesium;Malignant Neoplasms;Mammals;Mediating;member;Membrane;Messenger RNA;migration;Minus End of the Microtubule;Molecular;Movement;Mus;Mutation;Nerve Degeneration;novel;nutrient deprivation;Nutritional Immunity;Organ;Organelles;overexpression;Oxidative Stress;Pathway interactions;Peripheral;Peritoneal;Phenotype;Physiological;Physiological Processes;Play;Positioning Attribute;Predisposition;prevent;Production;programs;Proteins;Quantitative Reverse Transcriptase PCR;receptor;recruit;Recycling;Regulation;repaired;response;Rest;Role;Salmonella typhi;sensor;Signal Transduction;Starvation;Stress;Surface;System;TFE3 gene;Tissues;Toxic effect;trafficking;transcription factor;transcriptomics;TRP channel;Ubiquitination;Universities;Vestibular dysfunction;Work;Zebrafish

PROJECT_TITLE: Regulation of the Endo/Lysosomal pathway


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: BOEHM, MANFRED  (contact)

PROJECT_TERMS: 5'-Nucleotidase;Acceleration;Adhesions;Adult;Affect;Aneurysm;angiogenesis;Arterial Intimas;arterial tortuosity;Arteries;Atherosclerosis;Atherosclerosis Risk in Communities;autoinflammatory diseases;autosome;Benign;biobank;Biological Assay;Biological Models;biomarker identification;Blood flow;Blood Vessels;Body System;CADASIL;calcification;Calcium;Candidate Disease Gene;Cardiac;Cell Line;Cells;Childhood;Choristoma;Chronic;Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature;Chronic Disease;Chronic Kidney Failure;Clinical;Clinical Research;clinical trial analysis;Coculture Techniques;Collaborations;Collagen;Communication;Complex;Complication;Computerized Medical Record;Connective Tissue;COVID-19 patient;Cutaneous;Dasatinib;Data;Data Analyses;database of Genotypes and Phenotypes;Defect;Degos disease;Dermal;Diagnostic;Dilatation - action;Disease;disease model;Disease Outcome;Disease Progression;DNA Sequence Alteration;Drug Screening;Echocardiography;effectiveness testing;Electrocardiogram;Endothelial Cells;Endothelium;Enrollment;Enzymes;Exons;extracellular;Extracellular Matrix;Extravasation;Face;Fatal Outcome;Fibroblasts;Fibrosis;gain of function mutation;Gene Mutation;General Population;Genes;Genetic;Genetic Diseases;genetic testing;Grant;Granulation Tissue;Haplotypes;healing;Health;health care service;health record;Healthcare;Hepatomegaly;Hyper-IgE Syndrome;hypoperfusion;hypoxia inducible factor 1;imaging study;Immune;Immune system;immunodeficiency;improved;In Vitro;in vivo;induced pluripotent stem cell;Infection;Inflammation;inflammatory modulation;Inherited;inhibitor;insight;Integrins;Intellectual functioning disability;Intercellular adhesion molecule 1;Israel;Job's Syndrome;Joints;kinase inhibitor;large datasets;Life;Liver Fibrosis;Lower Extremity;Lung;LYN gene;Magnetic Resonance Imaging;Manuscripts;Maps;Mediating;Memory Loss;Mesenchymal;Metabolic Pathway;Metabolism;Microvascular Dysfunction;Microvascular Permeability;Migraine;migration;Modeling;Molecular;mouse model;Multiple Abnormalities;Mutation;Myocardial Infarction;National Heart, Lung, and Blood Institute;Nature;Neonatal Onset Multisystem Inflammatory Disease;neutrophil;Neutrophil Infiltration;Non-Insulin-Dependent Diabetes Mellitus;NOTCH3 gene;Nucleotidases;optical imaging;Organ;Oxygen;Pathway interactions;Patients;Perinatal;Perivascular Fibrosis;Pharmaceutical Preparations;Phase;Phenotype;Phosphotransferases;Population;post-COVID-19;programs;Proline;Proteins;Proteomics;psychiatric symptom;Publishing;Pulmonary Hypertension;Purines;Rare Diseases;rare genetic disorder;recessive genetic trait;recurrent infection;Reporting;Research;research clinical testing;Research Technics;Resources;Risk Factors;Role;screening;side effect;Signal Pathway;Signal Transduction;single cell sequencing;Skin;skin ulcer;slug;Spleen;src-Family Kinases;STAT3 gene;Stroke;Subarachnoid Hemorrhage;System;Systemic hypertension;systemic inflammatory response;TBK1 gene;Technology;Testing;Therapeutic;therapeutic target;Time;Tissues;TNF gene;tool;transcriptome sequencing;Treatment Protocols;treatment strategy;vascular abnormality;Vascular blood supply;Vascular calcification;Vascular Diseases;Vascular Endothelial Cell;Vascular remodeling;Vascularization;Vasculitis;whole genome;wound healing;Xaa-Pro dipeptidase

PROJECT_TITLE: Vascular remodeling in patients with rare genetic disorders


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

PROJECT_TERMS: Acceleration;Acute;Affect;angiogenesis;Angiogenic Factor;Angioplasty;Arterial Injury;arterial remodeling;Arteries;Atherosclerosis;autosome;Biological Assay;Blood capillaries;blood perfusion;Blood Vessels;Capillarity;Cell Culture Techniques;Cell Lineage;Cell Proliferation;Cell Survival;cell type;Cells;Clinical;clinically relevant;Compensation;Complex;Coronary Artery Bypass;Cromolyn Sodium;Defect;density;Development;Diabetes Mellitus;Disease;Drug Targeting;Dysplasia;Early Diagnosis;Effectiveness;Endothelial Cells;endothelial dysfunction;Endothelium;Environment;Event;Extracellular Matrix;Faith;femoral artery;Fibroblasts;Fibrosis;graft failure;Granulation Tissue;Growth;healing;HIF1A gene;Hindlimb;Human;Hyper-IgE Syndrome;Hyperplasia;hypoxia inducible factor 1;immune cell infiltrate;Immune response;Immunodeficient Mouse;improved;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;Intervention;Ischemia;Job's Syndrome;Knock-out;Legal patent;Ligation;Link;Lung Diseases;mast cell;Mast Cell Stabilizer;Medial;Mediating;Mediator;Mesenchymal;Modeling;Morphology;mouse model;Mus;Muscle;Mutation;novel;Outcome;Pathologic;Pathology;Pathway interactions;Patients;percutaneous coronary intervention;Perioperative;Pharmaceutical Preparations;Phase;Phenotype;Phosphorylation;Physiology;Play;Postoperative Period;prevent;Procedures;Process;Property;restenosis;restoration;revascularization;Role;Signal Pathway;Signal Transduction;Skin;Skin wound healing;slug;Smooth Muscle Myocytes;Splint Device;STAT3 gene;stem cells;Stents;Structural defect;Structure;Subcutaneous Injections;System;Teratoma;Testing;therapeutic target;Thrombosis;Tissues;Topical application;Transforming Growth Factor beta;Tube;vascular abnormality;Vascular calcification;Vascular Diseases;Vascular remodeling;vascular smooth muscle cell migration;Vein graft;vein occlusion;Veins;wound;wound closure;wound healing;Wound models;wound treatment

PROJECT_TITLE: Murine models of vascular remodeling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Hematology;Lung;Neurodegenerative;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PROJECT_TERMS: Academy;Address;Adenosine;Adenosine A2B Receptor;adenosine deaminase;adenosine deaminase deficiency;Affect;Animal Model;Arterial Disorder;Atrophic;autoinflammatory;autosome;Benign;biobank;Biological Assay;Biological Models;Biotechnology;Blood;blood vessel occlusion;Blood Vessels;Bone marrow failure;Brain Infarction;Cachexia;calcification;Cardiac Myocytes;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;Cell Line;Cell Lineage;Cell model;cell replacement therapy;cell type;Cells;Central Nervous System;Cerebrum;Characteristics;Chemicals;Chronic;Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature;Cicatrix;Clinical;Coculture Techniques;Collaborations;Core Facility;CRISPR correction;CRISPR/Cas technology;Cutaneous;Death Rate;Degos disease;Dental Porcelain;Development;Diagnosis;differentiation protocol;Disease;disease model;Drug Targeting;early onset;Endothelial Cells;Endothelium;Etiology;Exhibits;experience;experimental study;Eye;Fibrosis;Functional disorder;gastrointestinal perforation;Gastrointestinal tract structure;gene correction;gene editing technology;Gene Expression Profile;Gene Mutation;Genes;Genetic;Genetic study;Germ Layers;healthy volunteer;Heart;Heart failure;Hematopoietic;Human;human induced pluripotent stem cells;Hyper-IgE Syndrome;immunodeficiency;improved;In Vitro;in vivo;induced pluripotent stem cell;induced pluripotent stem cell technology;infancy;Inflammation;Inflammatory;Job's Syndrome;Lesion;loss of function mutation;Lung;lung failure;Macrophage;Malignant - descriptor;Mesenchymal;Mesenchymal Stem Cells;Mesoderm;Modeling;Molecular;monocyte;Mus;Mutation;National Heart, Lung, and Blood Institute;novel;novel therapeutic intervention;Organ;Organoids;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;Play;Production;Publications;Pulmonary Fibrosis;Pulmonary Inflammation;rare condition;rare genetic disorder;Research;Role;Sampling;Science;self-renewal;Sepsis;Signal Pathway;Skin;small molecule;Smooth Muscle Myocytes;Somatic Cell;Spinal;Stat3 protein;Stem Cell Research;Stimulator of Interferon Genes;STING1 gene;Stroke;Subcortical Infarctions;Subcortical Leukoencephalopathy;Syndrome;System;systemic inflammatory response;Technology;Teratoma;Testing;Therapeutic;Toxicology;transcription factor;Transgenic Mice;Turner's Syndrome;Up-Regulation;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Vascularization;Vasculitis

PROJECT_TITLE: iPS-technology and patient specific disease models


PI_NAMEs: NEUMAN, KEIR  (contact)

PROJECT_TERMS: Address;Antibodies;Binding;Biological;biomaterial compatibility;Blinking;Canada;cell determination;cell type;Cells;Cellular biology;cellular imaging;Characteristics;Chemical Structure;chemotherapeutic agent;Classification;Collaborations;Detection;Development;Diamond;Doxorubicin;Dyes;Encapsulated;Fingerprint;Fluorescence;fluorescence imaging;fluorophore;Goals;Image;imaging approach;imaging probe;imaging study;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;indexing;interest;Kinesin;Label;Laboratories;Lead;Methods;Microtubules;Modification;molecular imaging;Motor;Multimodal Imaging;nanocrystal;nanodiamond;nanoparticle;Neurons;Nitrogen;Noise;Nucleosome Core Particle;optic trap;optical imaging;optical traps;Optics;particle;Pathway interactions;Penetration;perovskite;Postdoctoral Fellow;Property;Protocols documentation;Publishing;Quebec;Research;Scheme;Side;Signal Transduction;single molecule;Small Interfering RNA;South Korea;Surface;Techniques;Testing;Tissues;Toxic effect;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Development and characterization of optical imaging probes


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: YOUNG, NEAL S (contact)

PROJECT_TERMS: acronyms;Age;Aplastic Anemia;Architecture;Arteritis;Artificial Intelligence;autoinflammation;autoinflammatory;autoinflammatory diseases;B-Lymphocytes;Biology;biomedical referral center;Blood Tests;Bone Marrow;Bone marrow failure;bone marrow failure syndrome;Brazil;Cell Line;Cell surface;Cells;Childhood;Chromosomal Stability;Chromosomes;Clinic;Clinical;clinical diagnosis;Clonal Evolution;Clonal Expansion;Clonality;Collaborations;conditioning;Constitution;Cytokine Gene;cytopenia;Danazol;Data;Decanoates;Degradation Pathway;Dermatologic;Diagnosis;Diamond-Blackfan anemia;Differential Diagnosis;Discrimination;Disease;DNA sequencing;DNMT3a;Dose;Dysmyelopoietic Syndromes;Engraftment;Enzymes;Etiology;Failure;Fanconi's Anemia;Fatal Outcome;GATA2 deficiency;Genes;Genetic;Genetic Diseases;Genomics;Germ Lines;helicase;Hematological Disease;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;High Prevalence;Human;Immune;Immune system;Immunology;immunosuppressed;improved;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;interest;Interferon Type II;Intervention;Lead;Length;Link;link protein;Lymphoid;Machine Learning;Macrophage;male;Malignant - descriptor;Malignant Neoplasms;Marrow;men;Mendelian disorder;Methodology;middle age;misfolded protein;monocyte;Mutate;Mutation;Myelogenous;Myeloproliferative disease;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Natural Killer Cells;older men;older patient;Older Population;Organ;Organ failure;Outcome;overexpression;paroxysmal nocturnal hemoglobinuria;Pathway interactions;Patients;Pattern;peripheral blood;Pharmaceutical Preparations;Phenotype;Population;Prognosis;Promoter Regions;Protocols documentation;Publications;Recurrence;Regimen;repaired;Reporting;Research;rheumatologist;Risk;Role;RUNX1 gene;Sampling;Secondary to;Signal Transduction;single-cell RNA sequencing;Stem cell transplant;stem cells;Symptoms;Syndrome;T-Lymphocyte;telomere;Testing;Thrombosis;Time;TINF2 gene;TNF gene;tool;transcriptome sequencing;United States National Institutes of Health;Up-Regulation;Vacuole;Vasculitis;Venous;web site

PROJECT_TITLE: Telomere Diseases and Other Constitutional and Acquired Genetic Disorders of Hematopoiesis


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease

PI_NAMEs: REMALEY, ALAN THOMAS (contact)

PROJECT_TERMS: Animals;Apolipoprotein A-I;Apolipoprotein E;Apolipoproteins;Apolipoproteins C;Biological;Cardiovascular Diseases;Cells;clinical center;Clinical Protocols;Clinical Trials;computerized data processing;Development;Dose;Drug Delivery Systems;drug testing;Excision;Generations;Goals;High Density Lipoproteins;Hydrocarbons;Hypertriglyceridemia;Inflammation;Infusion procedures;Ligands;Lipoproteins;Low Density Lipoprotein Receptor;Paper;Penetration;Peptides;peptidomimetics;Pharmaceutical Preparations;phase 1 study;Property;Proteins;Proteolysis;Protocols documentation;Publishing;receptor;Resistance;Structural Protein;Therapeutic;United States National Institutes of Health;Work

PROJECT_TITLE: Development of Apo Mimetic Peptides for the Treatment  Cardiovascular Disease


NIH_SPENDING_CATS: Clinical Research

PI_NAMEs: MOSS, JOEL  (contact)

PROJECT_TERMS: Annual Reports;Clinical Research;Collection;Extramural Activities;Human;human tissue;Individual;information processing;Institutional Review Boards;Principal Investigator;Process;programs;Protocols documentation;Reporting;Research;Research Personnel;Research Subjects;Running;sample collection;Specimen;Surveys;Tissue Sample;Translational Research

PROJECT_TITLE: Clinical and Translational Research


PI_NAMEs: TARASKA, JUSTIN  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Adhesions;Apical;Architecture;Area;Biochemistry;Capsid Proteins;Caveolae;Caveolins;Cell Communication;Cell Line;Cell membrane;Cell Physiology;Cell surface;Cells;Chemicals;Clathrin;CLC Gene;Coated vesicle;Color;Complex;cryogenics;Cytosol;Data;Development;Diameter;Disease;Dynamin;Dynamin 2;EGF gene;Electron Microscopy;electron tomography;Electrophysiology (science);Endocytosis;Endocytosis Inhibition;Environment;Epidermal Growth Factor Receptor;EPS15 gene;Exocytosis;extracellular;Extracellular Matrix;Ferritin;FGFR1 gene;Fluorescence;fluorescence imaging;Fluorescence Resonance Energy Transfer;G-Protein-Coupled Receptors;Gene Expression;Genetic;genetic regulatory protein;Goals;Growth;Growth Factor;Heterogeneity;Homeostasis;Human;Human Biology;Image;imaging modality;improved;Individual;Integrins;knock-down;Lifting;Ligands;light microscopy;Lipids;live cell imaging;Location;Mammalian Cell;Maps;Measures;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Methods;microscopic imaging;Microscopy;Modeling;Molecular;Molecular Conformation;Morphology;Names;nanoscale;Nature;Neck;Organelles;particle;pathogen;Pathway interactions;Peptides;Pharmaceutical Preparations;Phosphotransferases;physical property;Platinum;pressure;prevent;Procedures;Process;programs;Proteins;Protocols documentation;receptor;Receptor Signaling;recruit;Regulation;Resolution;Role;Shapes;Signal Pathway;Signal Transduction;Site;small molecule;src-Family Kinases;Standardization;Structure;Surface;System;targeted cancer therapy;Testing;tool;trafficking;Transmission Electron Microscopy;ultra high resolution;Update;uptake;vesicle transport;Visualization;Work

PROJECT_TITLE: Architecture and control of exocytosis and endocytosis in excitable cells


NIH_SPENDING_CATS: Genetics

PI_NAMEs: FERRÉ-D'AMARÉ, ADRIAN  (contact)

PROJECT_TERMS: 5' Untranslated Regions;Alternative Splicing;Anti-Bacterial Agents;Antibiotics;Binding;Binding Proteins;Biological Models;Biophysics;Catheters;Cell Aging;Cells;Chemicals;Clinical;Complex;Disease;DNA-Directed RNA Polymerase;Elements;Family member;Future;Gene Expression;Genes;Genetic Transcription;Health;Implant;interest;Major Groove;member;Messenger RNA;Microbial Biofilms;Morbidity - disease rate;mortality;mRNA Decay;nutrition;Nutritional;Operon;Physiological;Physiology;Procedures;Protein Family;Proteins;Reporting;Resolution;response;Ribonucleoproteins;RNA;RNA Binding;small molecule;stem;Structure;Study Subject;Surface;Telomerase;Tissues;Transcriptional Elongation Factors;Transcriptional Regulation;Translations;tumor growth;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: RNA: Structure, Biophysics and Physiology


NIH_SPENDING_CATS: Nutrition;Obesity

PI_NAMEs: CAO, HAIMING  (contact)

PROJECT_TERMS: clinical application;Code;Diabetes Mellitus;Drug Targeting;Dyslipidemias;Exhibits;fatty liver disease;Genes;glucose metabolism;Health Care Costs;Human;Link;lipid metabolism;Mammals;Metabolic;Metabolic Diseases;metabolic rate;Molecular;Mus;novel;Obesity;Obesity Epidemic;obesity treatment;Pathogenesis;Pathologic;Play;Proteins;Role;Therapeutic Agents;therapeutically effective;Translating;Untranslated RNA

PROJECT_TITLE: Molecular Basis of Obesity and Obesity-induced Metabolic Diseases


NIH_SPENDING_CATS: Biotechnology;Cerebrovascular;Genetics;Lymphatic Research;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: MUKOUYAMA, YOH-SUKE  (contact)

PROJECT_TERMS: Astrocytes;Blood - brain barrier anatomy;Blood Circulation;Blood Vessels;Brain;brain endothelial cell;Cell Communication;Cells;Cellular biology;Central Nervous System;Characteristics;Complex;Data;Development;Developmental Biology;Dura Mater;Ectopic Expression;Endothelial Cells;endothelial stem cell;Environment;frontier;Gene Expression Profiling;genetic manipulation;Genetic Transcription;Heart;Hemorrhage;high resolution imaging;IGF1 gene;Immune system;Individual;Link;lymph nodes;Lymphatic;Lymphatic Endothelial Cells;lymphatic vasculature;lymphatic vessel;Macrophage;Mammals;Manuscripts;Membrane;Meningeal;Mitosis;Molecular;Morphology;nerve stem cell;Neuroglia;Neurons;neurovascular;Organ Culture Techniques;Pattern;Pericytes;Peripheral;Preparation;prevent;programs;Radial;Reporting;Repression;Research;Role;Signal Transduction;Skin;Source;Spinal Cord;Structure;Surface;Tight Junctions;Tissues;transcription factor;transdifferentiation;Transgenes;Vascularization;Venous;Zebrafish

PROJECT_TITLE: The study of neuro-vascular interactions in the central nervous system


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

PROJECT_TERMS: 3-Dimensional;Adrenergic Agents;Affect;angiogenesis;Axon;Biological Models;Blood capillaries;Blood Circulation;Blood flow;Blood Vessels;Cardiac Myocytes;Cells;Chick;chorioallantoic membrane;Coculture Techniques;coronary vasculature;Cyclic AMP;Development;Dextrans;Diameter;Embryo;Embryonic Development;embryonic stem cell;Embryonic Stem Cell Transplantation;Endothelial Cells;Exhibits;experimental study;Future;Gene Expression;genetic manipulation;Heart;hemodynamics;Imaging Techniques;In Vitro;in vivo;induced pluripotent stem cell;Injections;Laboratories;Manuscripts;Modeling;Molecular;Mouse Embryonic Stem Cells;Mutation;Myocardial;Nerve;nerve supply;neuronal guidance;Neurons;neurovascular;Organ;Organ Culture Techniques;Organoids;Pattern;Pericytes;Play;postnatal;Preparation;Proliferating;Property;Protocols documentation;Regulation;Role;Signal Pathway;Skin;Smooth Muscle;Smooth Muscle Myocytes;Structure of left gastric vein;Structure of omphalomesenteric vein;System;Transplantation;Vascular remodeling;Vascular Smooth Muscle;vasculogenesis;Venous

PROJECT_TITLE: The study of neuro-vascular interactions in the developing heart


PI_NAMEs: CHUNG, JAY H (contact)

PROJECT_TERMS: Aging;aging related;Apoptosis;biological adaptation to stress;Chronic;Defect;DNA;endonuclease G;Energy Metabolism;Fatty acid glycerol esters;Genetic Transcription;Heart Diseases;Hybrids;Hypertension;Individual;Inflammation;Liver;Liver diseases;male;Malignant Neoplasms;Metabolic dysfunction;microscopic imaging;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Oxygen Consumption;prevent;pro-aging;Production;recruit;Respiration;Risk;RNA Helicase;Supplementation;Technology;Threonine-Specific tRNA;Transcript;Transfer RNA;Translations;Visualization

PROJECT_TITLE: Stress response and energy metabolism as a function of aging


PI_NAMEs: HAMMER, JOHN A (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;adaptive immune response;Adhesions;Adhesives;Antigen-Presenting Cells;Antigens;Apical;B-Lymphocytes;base;Binding;blebbistatin;Cell Adhesion;Cell division;cell motility;Cell Nucleus;Cell Shape;Cells;Cellular biology;Centrosome;chemokine;cohesion;Complement;Complex;Cytoskeleton;daughter cell;Defect;Dendritic Cells;Dermal;driving force;Embryo;Ensure;Enterocytes;Environment;Epithelium;Exhibits;experimental study;Extracellular Matrix;Fiber;Fibroblasts;Filament;Frequencies;Hela Cells;Image;immunodeficiency;immunological synapse formation;Impairment;In Vitro;Individual;Integrin Binding;Integrins;Interphase;Intestines;knock-down;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Lateral;Lead;Light;Link;live cell imaging;Maintenance;Mediating;Mediation;Membrane;Mesenchymal;Metaphase;Microfilaments;Microfluidic Microchips;Microtubule-Organizing Center;Microtubules;migration;Mitosis;Mitotic spindle;Molecular;Molecular Motors;Motor;Mus;Myosin ATPase;Myosin S-2;Nuclear;Organoids;Phenocopy;Play;Positioning Attribute;Proteins;Resolution;Role;Running;Side;Signal Transduction;Skin;small hairpin RNA;Speed;Stains;stem cells;Structure;superresolution imaging;Supporting Cell;Surface;T-Lymphocyte;Tissue Model;Tubulin;uptake;Villus

PROJECT_TITLE: Motor proteins and cytoskeletal dynamics in T cells, B cells and mesenchymal cells


NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

PROJECT_TERMS: Alleles;Ataxia;Axon;Biological Models;calbindin;CDK6-associated protein p18;Cell Polarity;cell type;Cells;Cerebellar Cortex;Cerebellum;Cessation of life;conditional knockout;Congenital cerebellar hypoplasia;Cre driver;Defect;Demyelinating Diseases;Dendritic Spines;density;design;Development;differentiation in vitro;Electrons;Endoplasmic Reticulum;Equilibrium;Exhibits;Filopodia;Future;Goals;Guanine Nucleotide Exchange Factors;hippocampal pyramidal neuron;Image;In Vitro;in vivo;knock-down;knockout animal;Knockout Mice;Learning;Length;Lobe;Mediating;MicroRNAs;Molecular;Morphology;Motor;motor learning;Mus;mutant;Myelin;Myelin Basic Proteins;Myelin Sheath;myelination;MYO5A gene;Myosin ATPase;nanowire;nerve supply;Neurites;Neurologic;neuronal cell body;Neurons;oligodendrocyte progenitor;Oligodendroglia;Optic Nerve;Organ;Output;Persons;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Process;Proteins;Role;Seizures;Severities;Signal Transduction;Slice;Spasm;Stains;Structure;Symptoms;Synaptic plasticity;Tissues;Tonic - clonic seizures;Vertebral column;Work

PROJECT_TITLE: Roles of motor proteins in neurons


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: RUSAN, NASSER  (contact)

PROJECT_TERMS: Amino Acid Substitution;Amino Acids;Animals;Architecture;Automobile Driving;Binding;biochemical tools;Brain;C-terminal;Cell Cycle;cell motility;Cell Nucleus;Cell Polarity;cell type;Cells;Centrioles;Centrosome;Chromosome Segregation;Complex;Coupling;Data;Daughter;Defect;Development;Disease;Distal;Drosophila genus;Embryo;Ensure;Equilibrium;Event;Evolution;experience;Failure;Fertilization;fly;Future;Gene Duplication;Genetic;germline stem cells;Goals;Growth;Haploid Cells;Head;Homeostasis;Human;Imaging Device;insight;Interphase;kinetosome;Label;Length;Lighting;Link;Location;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Meiosis;Microcephaly;Microscopy;Microtubule Polymerization;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic;Mitotic spindle;model organism;Modeling;Molecular;Mothers;mRNA Transcript Degradation;Mutation;nerve stem cell;novel;Nuclear;Open Reading Frames;Organelles;overexpression;paralogous gene;Physiology;Play;polarized cell;Polycystic Kidney Diseases;Positioning Attribute;Post-Translational Protein Processing;prevent;protein degradation;protein function;Protein Isoforms;Proteins;recruit;Regulation;Relaxation;response;RNA;Role;scaffold;Secure;Side;Site;sperm cell;Sperm Head;Sperm Motility;Sperm Tail;Spermatids;Spermiogenesis;stem cells;Structure;Study models;Surface;Tail;Time;Tissues;Transgenes;Translations;Visualization;Work

PROJECT_TITLE: Centrosome Regulation in Development and Dysregulation in Disease


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Kidney Disease;Networking and Information Technology R&D (NITRD)

PI_NAMEs: KNEPPER, MARK  (contact)

PROJECT_TERMS: Acetylation;Address;Algorithms;Antibodies;Antibody Formation;ATAC-seq;Atlases;Big Data;Bioinformatics;cell type;ChIP-seq;Code;Communities;Computer software;computerized data processing;computerized tools;Data;data integration;data resource;Data Science;Data Set;data sharing;Databases;Democracy;design;Differential Equation;Duct (organ) structure;Enhancers;Ensure;Epithelium;equilibration disorder;Functional disorder;Gene Expression;Gene Expression Regulation;Graph;Histones;improved;indexing;Information Systems;Investigation;Java;Kidney;Knowledge;Laboratories;mass spectrometer;Mass Spectrum Analysis;mathematical model;Measures;member;Messenger RNA;Methodology;Methods;Modeling;Molecular;Multiomic Data;multiple omics;next generation sequencing;novel;Nucleic Acids;Performance;phosphoproteomics;Phosphorylation;Physiological;Physiology;Production;protein aminoacid sequence;Proteins;Proteomics;Pythons;Regional Perfusion;Regulation;renal epithelium;Renal tubule structure;Research;Research Personnel;response;RNA Polymerase II;single-cell RNA sequencing;Sodium Chloride;Software Tools;Structure;synthetic peptide;System;Systems Biology;Techniques;tool;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transport Process;Urea;user-friendly;Vasopressins;Water;water channel;Work

PROJECT_TITLE: Computational Tools for Proteomics


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Coronaviruses;Hematology;Lung;Lymphatic Research;Patient Safety;Primary Immunodeficiencies;Rare Diseases;Women's Health Research

PI_NAMEs: WEN, HAN  (contact)

PROJECT_TERMS: Affect;Agreement;Air;Ankle;Anxiety;Area;Arterial calcification due to deficiency of CD73;autosome;Back;Blood Vessels;calcification;Calibration;Cancer Patient;Clinical;clinical application;clinical care;clinical center;Clinical Protocols;Clinical Research;Code;Collaborations;Computed Tomography Scanners;Computer software;COVID-19 patient;Cyst;Data;Data Analyses;density;Development;Diffusion;Disease;Disease Management;Disease Progression;FDA approved;foot;Future;Genetic Diseases;Growth;Hand;High Resolution Computed Tomography;Human;Hyper-IgE Syndrome;Image;Image Analysis;improved;Job's Syndrome;Joints;Judgment;Limb structure;long term consequences of COVID-19;Lower Extremity;Lung;Lung Capacity;Lung Diseases;lung volume;Lymphangioleiomyomatosis;Manuals;Measurement;Measures;Medical;Medicine;Methods;Monitor;Mosses;Mucous body substance;Muscle Cramp;National Heart, Lung, and Blood Institute;pain symptom;participant enrollment;Patients;Photons;post-COVID-19;Predisposition;procedure safety;Procedures;Protocols documentation;Publishing;pulmonary function decline;Pulmonary function tests;Radiology Specialty;rare genetic disorder;rate of change;Renal Carcinoma;Reporting;research clinical testing;Residual state;Resolution;routine care;SARS-CoV-2 infection;Scanning;Symptoms;System;Technology;Tissues;tool;Training;Transplantation;treatment effect;treatment response;trend;ultra high resolution;Uncertainty;Update;validation studies;Vascular calcification;Vascular Diseases;Visual;Woman;Work;X-Ray Computed Tomography

PROJECT_TITLE: quantitative CT development and clinical applications


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Hydrocephalus;Rare Diseases

PROJECT_TERMS: Animal Model;Aorta;Apolipoprotein E;Apolipoproteins;Atherosclerosis;Blood Vessels;calcification;Cardiovascular Diseases;Collaborations;Computer software;Deposition;Fresh Tissue;Gene Modified;genetic variant;Histopathology;Hydrocephalus;Individual;Knockout Mice;Label;Link;Manuscripts;Measurement;microCT;Modeling;Mus;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;Pathology;Sampling;Technology;Tissue Sample;Tissues;Variant;Work;X ray microscopy

PROJECT_TITLE: X-ray micro tomography of pathology tissue samples


NIH_SPENDING_CATS: Genetics;Human Genome;Sleep Research

PI_NAMEs: HARBISON, SUSAN  (contact)

PROJECT_TERMS: Alleles;ATAC-seq;Bayesian Modeling;behavioral phenotyping;Biological Assay;Brain;Characteristics;Chest;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Communities;Complex;CRISPR/Cas technology;Data;differential expression;Disease;DNA Sequence;Drosophila genus;Drosophila melanogaster;Effectiveness;experimental study;fitness;fly;Freezing;Frequencies;functional genomics;Gene Expression;Gene Frequency;gene interaction;gene network;Generations;Genes;Genetic Polymorphism;Genetic Research;genetic variant;Genetic Variation;Genome;genome wide association study;Genomic DNA;Genomic Segment;Genotype;Goals;Human;Human Genome;Inbreeding;Indiana;Learning;life history;life span;Linkage Disequilibrium;Locomotion;Manuscripts;Measures;Memory;Memory impairment;Methods;model organism;Modeling;mutant;Mutation;Natural Selections;neural correlate;next generation;Parents;Partner in relationship;Pattern;Performance;Phenotype;Poly(A)+ RNA;Population;Procedures;Process;Publishing;Relaxation;Reporting;Resources;RNA;RNA Sequences;Sampling;Scheme;segregation;Sequence Homologs;sex;Short-Term Memory;Sib Matings;Signal Transduction;Single Nucleotide Polymorphism;Sleep;sleep regulation;SNP genotyping;Speed;Surveys;Testing;Time;trait;transcriptome sequencing;Transposase;Untranslated RNA;Variant;Work

PROJECT_TITLE: Verification of Polymorphisms Impacting Sleep


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PROJECT_TERMS: Adopted;Alternative Splicing;anti-microbial drug;Antibiotics;antimicrobial;ATP-Binding Cassette Transporters;Bacillus;Bacteria;Biochemical;Bioinformatics;biophysical properties;Catalytic RNA;Clostridium;cold temperature;Complex;Conserved Sequence;design;Development;Elements;functional group;Gene Expression;Genes;Genetic Transcription;Genus staphylococcus;Human;in vivo;insight;interest;Lead;Listeria;Metabolic Pathway;mRNA Decay;novel;novel therapeutics;pathogen;pathogenic bacteria;Reporter;Research;RNA;screening;Signal Pathway;small molecule;Specificity;Streptococcus;Structure;Study Subject;System;Temperature;Thermometers;three dimensional structure;tool;Transition Temperature;Translations;viral RNA;virulence gene

PROJECT_TITLE: RNA: New Antimicrobial Strategies


PROJECT_TERMS: Alanine;Animals;Anisomycin;Antioxidants;Autophagocytosis;betacoronavirus;Binding;Binding Sites;Biogenesis;biological adaptation to stress;Biological Response Modifiers;Caenorhabditis elegans;Cell Nucleus;Cell Physiology;cell type;Cells;chemokine;Chromatin;chromatin remodeling;Complex;Cues;cytokine;Cytosol;Data;DNA Damage;Ensure;epigenetic regulation;Exocytosis;Family;Family member;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Helix-Turn-Helix Motifs;Heterodimerization;Histones;Homeostasis;Immune;Immune response;Immunoprecipitation;Impairment;Infection;Inflammasome;Inflammatory;Knock-in;Laboratories;Leucine Zippers;Light;Lysosomes;Macrophage;MAP Kinase Gene;Mass Spectrum Analysis;Mediating;member;Mitochondria;Modification;Molecular;Molecular Chaperones;monocyte;Mutate;novel;Nuclear Translocation;Nucleosomes;nutrient deprivation;Organelles;Organism;Output;overexpression;Oxidation-Reduction;Oxidative Stress;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Phosphoric Monoester Hydrolases;Phosphorylation;Physical Exercise;Play;Post-Translational Protein Processing;preservation;prevent;programs;promoter;Protein Dephosphorylation;Protein-Serine-Threonine Kinases;Proteins;recruit;Regulation;Reporting;Research;response;Role;Serine;Signal Pathway;Stimulus;Stress;stressor;Surface;TFE3 gene;Transcription Coactivator;Transcription Elongation;transcription factor;Transcriptional Regulation;transcriptome sequencing;Up-Regulation;Viral;Work

PROJECT_TITLE: Lysosome biogenesis and homeostasis


PI_NAMEs: XU, HONG  (contact)

PROJECT_TERMS: Adenosine Triphosphate;Anabolism;Animals;Binding;Biogenesis;Bioinformatics;biological adaptation to stress;cell behavior;Cell Nucleus;Cell Physiology;Cellular Structures;Circular DNA;Communication;Complex;Cytoplasm;Defect;Deposition;Development;Disease;DNA amplification;DNA Repair;DNA Restriction Enzymes;Drosophila genus;egg;Electron Transport;Embryo;endoplasmic reticulum stress;Enhancers;Ensure;Enzymes;Excision;Exonuclease;Eye;Female;Fertilization;fly;Free Radicals;Gene Expression;Generations;Genes;Genetic;Genetic Phenomena;Genetic Transcription;Genome;Genomics;Germ Cells;Germ Lines;Goals;Health;Heart Diseases;heart function;Homeostasis;Human;human disease;Impairment;In Situ;insight;knock-down;Length;Life;Link;macromolecule;Maintenance;male;Membrane;Metabolic;Metabolic Pathway;Metabolism;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Mitochondrial Inheritance;Mitochondrial Proteins;Modeling;Molecular;Morphogenesis;mutant;Mutation;Nature;next generation;novel;Nuclear;nucleotide metabolism;NURF;Organelles;Organism;overexpression;Pattern;Pattern Formation;Phenotype;Physiological;prevent;Process;Protein Isoforms;Protein translocation;Protein Truncation;Proteins;proton-translocating pyrophosphatase;Regulation;Reproduction;Research;Respiration;response;Role;screening;Series;Sexual Reproduction;Signal Transduction;Single Nucleotide Polymorphism;sperm cell;Spermatids;Spermatogenesis;Sterility;Stress;Structure;sudden cardiac death;System;Tissues;transcription factor;Transgenes;transmission process;Variant;Work

PROJECT_TITLE: Mitochondrial DNA genetics and inheritance


PI_NAMEs: HOGG, J ROBERT  (contact)

PROJECT_TERMS: 3' Untranslated Regions;Address;Affect;Affinity;Affinity Chromatography;Apoptotic;ATP Hydrolysis;ATP phosphohydrolase;B-Cell Lymphomas;BCL-2 Protein;BCL2 gene;Binding;Binding Sites;Biochemical;Biogenesis;Biological;Biological Assay;biophysical techniques;Cell Nucleus;Cells;Collaborations;Complex;Cytoplasm;Data;Defect;Detection;Dissociation;DNA;Elements;Equilibrium;Event;Exhibits;Exons;flexibility;Gene Expression Regulation;Genetic Transcription;helicase;Heterogeneous-Nuclear Ribonucleoprotein L;Human;human disease;Immobilization;Immune;Impairment;in vitro Assay;inhibitor;insight;interest;Laboratories;Link;Malignant Neoplasms;Mechanics;Mediating;messenger ribonucleoprotein;Messenger RNA;Modeling;mutant;Mutation;National Center for Advancing Translational Sciences;Nonsense Codon;novel;Nucleic Acids;Pathway interactions;Physiological;Polyadenylation;premature;prevent;Process;Proteins;Proteomics;recruit;Repression;Research;Research Personnel;RNA;RNA Binding;RNA Decay;RNA Helicase;RNA interference screen;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Rous sarcoma virus;screening;Small Nuclear RNA;System;Terminator Codon;Time;Transcript;transcriptome;Translations;whole genome;Work

PROJECT_TITLE: Mechanisms of nonsense-mediated mRNA decay target selection


NIH_SPENDING_CATS: Bioengineering;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nanotechnology

PROJECT_TITLE: Functional and mechanistic studies of human-specific long noncoding RNAs using a humanized mouse model


PI_NAMEs: LEVINE, STEWART  (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;airway obstruction;American;Apolipoprotein A-I;Asthma;asthmatic;Biological Markers;Chronic;Clinical;Clinical Data;cohort;Collection;comorbidity;cost effective;Critical Care;Data;Disease;disorder control;effective therapy;eosinophil;Extrinsic asthma;Goals;High Density Lipoprotein Cholesterol;High Density Lipoproteins;Individual;Inflammation;Journals;Link;Lipids;Longitudinal, observational study;Manuscripts;Measures;Medicine;Natural History;NMR Spectroscopy;novel;novel therapeutics;Outcome;particle;Pathogenesis;Pathogenicity;Pathway interactions;Patients;periostin;personalized management;personalized medicine;Persons;Phenotype;Physiological;Protocols documentation;Public Health;Publishing;Pulmonary Function Test/Forced Expiratory Volume 1;Research;Resistance;respiratory;Sampling;Serum;Severity of illness;side effect;Specimen;Steroids;Testing;Time;Triglycerides

PROJECT_TITLE: Longitudinal Observational Study of Severe Asthma


PROJECT_TERMS: Adult;Affect;American;Behavioral;Birds;Body Weight;Candidate Disease Gene;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;comparative;CRISPR/Cas technology;Data;Databases;Defect;Development;Drosophila genus;Drosophila melanogaster;egg;Encyclopedia of DNA Elements;experimental study;falls;Female;Fertility;fitness;fly;FZD1 gene;gene conservation;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic architecture;Genetic Polymorphism;genetic testing;genome wide association study;Goals;Heritability;histone modification;Human;in silico;Inbreeding;Intercistronic Region;knock-down;Knock-out;knockout gene;Learning;Life;life history;life span;Link;Manuscripts;Maps;Measures;Mediating;Memory;Modification;Monitor;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;Natural Selections;neurodevelopment;Neurons;novel;novel strategies;Nucleic Acid Regulatory Sequences;Oocytes;Ovary;Paper;Phenotype;pleiotropism;Population;Prevalence;Process;Protocols documentation;Publishing;Relaxation;reproductive fitness;reproductive success;Reptiles;RNA Interference;Role;sex;Site;Sleep;Sleep Architecture;Sleep Disorders;Testing;Time;trait;Transcript;Tube;Work

PROJECT_TITLE: Inferring the function of sleep-associated polymorphisms across species


PROJECT_TERMS: Address;Alternative Splicing;Binding;Binding Proteins;Biochemical;Buffers;candidate identification;Catalogs;Cell Physiology;cell type;Complex;Cytoplasm;Cytoplasmic Granules;Data;Development;Disease;Double-Stranded RNA;ds RNA-Binding Proteins;Elements;Event;Exons;Gene Expression;Genetic Transcription;genetic variant;High-Throughput Nucleotide Sequencing;Histones;Human;In Vitro;Incubated;Innate Immune Response;interest;Interferon-beta;Interferons;macroH2A histone;Macrophage;Mammalian Cell;Mediating;messenger ribonucleoprotein;Messenger RNA;Methods;monocyte;mRNA Decay;mRNA Precursor;mRNA Stability;mRNA Transcript Degradation;mRNA Translation;Nerve Degeneration;novel;Pathway interactions;pharmacologic;Phase;Physiological;Play;Process;programs;protein expression;Protein Overexpression;Proteins;Proteomics;Regulation;Repression;Research;response;Ribonucleoproteins;RNA;RNA Decay;RNA Splicing;RNA-Binding Proteins;RNA-Protein Interaction;Role;Stress;Structure;System;Techniques;Transcription Initiation Site;transcriptome;transcriptome sequencing;Translation Initiation;Translational Repression;Translations;Variant;Zinc Fingers

PROJECT_TITLE: mRNP assembly in response to translational repression


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: DUNBAR, CYNTHIA E (contact)

PROJECT_TERMS: Agonist;Anemia;Annual Reports;Aplastic Anemia;Binding;Biology;Blood;Bone Marrow;Bone marrow failure;Chelating Activity;Clinical;Clinical Research;Clinical Trials;clinically relevant;clinically significant;Clonal Evolution;Cohort Studies;Collaborations;Congenital Disorders;Cyclosporine;Cytogenetics;cytopenia;Data;design;Development;Diamond-Blackfan anemia;Disease;Dose;Dysmyelopoietic Syndromes;Effectiveness;Erythroid;Erythropoiesis;Failure;follow-up;Functional disorder;Gene Proteins;Genes;Globin;Glycine;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Heme;heme biosynthesis;Human;imaging study;Immunosuppression;improved;In Vitro;in vivo;Incidence Study;Inherited;Inherited bone marrow failure;inhibitor;Investigation;Iron;Iron Chelating Agents;Iron Chelation;iron deficiency;iron metabolism;iron supplementation;Knowledge;Laboratory Study;Link;Malignant - descriptor;Marrow;Molecular;Morbidity - disease rate;mouse model;Mutation;Myeloproliferative disease;New Agents;novel therapeutics;Oral;Outcome;Output;participant enrollment;Pathway interactions;patient response;Patients;Pharmaceutical Preparations;predicting response;Production;progenitor;programs;Property;Protein Biosynthesis;Publishing;Reactive Oxygen Species;receptor;Refractory;Refractory anemias;Regimen;Relapse;Report (document);Reporting;Research;response;Ribosomal Proteins;ribosomopathy;Risk;Role;Safety;Sampling;screening;small molecule;Somatic Mutation;stem;stem cells;telomere;Therapeutic immunosuppression;thrombocytosis;Thrombopoietin;Time;Toxic effect;Translational Research;transport inhibitor;Work

PROJECT_TITLE: Investigation of underlying mechanisms and novel therapies for human acquired and congenital disorders of hematopoiesis


NIH_SPENDING_CATS: Biotechnology

PROJECT_TERMS: Affinity;analog;aptamer;Binding;Biophysics;Cellular biology;Compensation;Complex;Crystallography;design;Development;Disease;Dissociation;enthalpy;Entropy;Evolution;Family;Fluorescence;fluorophore;Goals;Green Fluorescent Proteins;Image;Imaging Device;improved;In Vitro;in vivo;insight;Ligands;Mango - dietary;Modification;Molecular;Mutation;nanomolar;next generation;novel;Pharmaceutical Preparations;Property;Proteins;Reporting;Research;Research Project Grants;RNA;small molecule;Spinach - dietary;Structure;thiazole orange;Time;tool;Variant;Visualization;Work

PROJECT_TITLE: RNA: Tools for Cell Biology


NIH_SPENDING_CATS: Genetics;Human Genome;Sleep Research;Social Determinants of Health

PROJECT_TERMS: Biological;Biology;Candidate Disease Gene;Cells;Complex;Darkness;Data;Deposition;differential expression;DNA;DNA sequencing;dosage;Drosophila genome;Drosophila genus;Drosophila melanogaster;Environment;Environmental Exposure;Environmental Risk Factor;Etiology;Evolution;experimental study;Face;Female;fly;Food;food environment;Freezing;Gene Expression;gene expression variation;Gene Frequency;Generations;Genes;Genetic;Genetic Polymorphism;genetic risk factor;genetic variant;genome wide association study;Genomics;Genotype;Goals;Guidelines;Harvest;Heritability;Homologous Gene;Hour;Human;Humidity;Inbreeding;Individual;individual variation;Laboratories;large datasets;Libraries;Light;Maintenance;male;Manuscripts;Maps;Measures;Mental disorders;Messenger RNA;Methodology;Methods;Modeling;Mutation;Narcolepsy;Noise;Nutrient;Phenotype;phenotypic data;Population;Publications;Publishing;Quality Control;Regulation;Research;response;RNA;RNA analysis;RNA Sequences;Sampling;sex;Sleep;Sleep Disorders;Statistical Data Interpretation;Sucrose;Testing;Time;trait;Transcript;transcriptome sequencing;Variant;Work;X Chromosome

PROJECT_TITLE: Assessment of variability in gene expression among genetically identical Drosophila subjected to a common environment


PROJECT_TERMS: adaptive immune response;ADP Ribose Transferases;Airway Disease;airway epithelium;airway inflammation;Allergens;Alveolar Macrophages;Apical;Apolipoproteins;Asthma;asthmatic;asthmatic patient;Attenuated;Binding;Blood;Blood specimen;bronchial epithelium;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Brush Cell;CD14 gene;Cell membrane;Cells;chemokine;Chemotaxis;Ciliated Bronchial Epithelial Cell;Clinical Immunology;Collection;cytokine;Cytokine Receptors;Dendritic Cells;eosinophil;eosinophilic asthma;Epithelial Cells;Epithelium;exosome;Extrinsic asthma;Fasting;FPR2 gene;Genes;Goblet Cells;High Density Lipoproteins;HLA-DR Antigens;Human;human neutrophil peptide 1;human old age (65+);human RNA sequencing;Hypersensitivity;Immune;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Interleukin-1;Interleukin-6;intravenous administration;ITGAX gene;Length;Ligands;Link;Lipids;Liquid substance;Lung;Macrophage;MAP3K7 gene;MAP3K8 gene;MAPK8 gene;Mediating;Membrane;Metaplasia;Microfluidics;Minor;Modification;monocyte;mouse model;mRNA Expression;Mus;Myelogenous;nanoscale;neutrophil;Neutrophil Activation;novel;Nutrient;Obesity;particle;Pathway interactions;patient subsets;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;point of care;Population;Prevalence;Production;Protocols documentation;Pyroglyphidae;receptor;Regulation;Research;Role;sample collection;Sampling;Serum;Serum amyloid A protein;Severity of illness;Signal Pathway;Signal Transduction;soluble TNF receptor type I;Sputum;Steroids;systemic inflammatory response;Th2 Cells;Time;Tissue Procurements;TLR4 gene;TNF gene;Transcript;Triglycerides;Tumor Necrosis Factor Receptor;vesicular release;Viral;VLDL receptor;volunteer

PROJECT_TITLE: Asthma Sample Collection Protocol:  Defining the Role of  Apolipoprotein Pathways in Asthma


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Heart Disease;Intellectual and Developmental Disabilities (IDD);Orphan Drug;Pediatric;Prevention;Rare Diseases

PI_NAMEs: KOZEL, BETH  (contact)

PROJECT_TERMS: Abdominal Pain;Action Potentials;Adult;Affect;Anesthesia procedures;Animal Model;Animals;Area;Arrhythmia;Arterial Disorder;arterial stiffness;Arteries;bench to bedside;Biological Markers;Blood capillaries;Blood flow;Blood Pressure;Blood Vessels;Body Weight decreased;Brain;Calcium;Cardiac;Cardiac Myocytes;Caring;Cell Count;Cells;Choking;Clinical;Constipation;Coronary;Coronary Vessel Anomalies;Data Collection;Death Rate;Deglutition Disorders;Development;Diameter;Diarrhea;Disease;Dissociation;Effectiveness of Interventions;Elastin;Equilibrium;Evaluation;falls;Feeds;Food;Gagging;Gastroenterologist;Gastrointestinal Diseases;Gastrointestinal tract structure;Health;Heart;Heart Rate;heart rate variability;Hematochezia;hemodynamics;Hospitals;Human;Hypertension;imaging modality;Individual;insight;Investigation;Kidney;Kinetics;Knowledge;Literature;Manuscripts;Mechanics;Mediating;medical specialties;Microvascular Dysfunction;Modeling;mortality;mortality risk;Mus;Myocardial dysfunction;Natural History;normal aging;novel;novel therapeutics;Organ;Paper;Patients;Pattern;Perfusion;Persons;Pharmaceutical Preparations;Phenotype;Physiologic pulse;Population;Potassium;Preparation;Procedures;Process;Protocols documentation;Publishing;Pulse Rates;Rectal Prolapse;Reflux;Reporting;Research Design;Rest;Retina;Risk;Risk Assessment;risk mitigation;Smooth Muscle Myocytes;Stenosis;Sudden Death;Testing;therapy design;Tissues;translational approach;United States National Institutes of Health;vascular contributions;Vascular Diseases;Ventricular Fibrillation;Visualization;Vomiting;wearable device;Williams Syndrome;Work

PROJECT_TITLE: Williams syndrome: A Translational Approach to Mechanism and Treatment


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Rare Diseases

PROJECT_TERMS: Adaptive Immune System;Affect;Anatomy;Animal Model;Area;Arterial Disorder;Blood Vessels;Canada;Cardiac;Catheters;Cell Cycle;cell type;Cells;Cessation of life;Characteristics;Child;Chromosome 7;Code;cohort;Collaborations;Data;Development;Disease;disease-causing mutation;disorder risk;Echocardiography;EFRAC;Elastin;Electron Microscopy;Estrogens;exome;Extracellular Matrix;Failure to Thrive;falls;Fatty acid glycerol esters;follow-up;Frequencies;Gastrointestinal tract structure;Genes;Genetic;Genetic Variation;genome sequencing;Genomics;Goals;Growth;GTP-Binding Proteins;Heterozygote;Hour;Human;Human Chromosomes;Hypertension;Immune;improved;Individual;Intervention;Italy;Knockout Mice;lean body mass;Life;lipid metabolism;Location;loss of function;male;Manuscripts;Measures;metabolic abnormality assessment;Mitochondria;Modeling;mouse model;Mus;mutant;Neural Crest;Operative Surgical Procedures;Paper;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Persons;Phenotype;Physicians;Publishing;rare variant;Registries;Research;research clinical testing;risk prediction;Sampling;Scientist;Severities;Signal Pathway;Signaling Protein;Source;Stenosis;surgical risk;targeted treatment;Techniques;Texas;Therapeutic;Tissues;transcription factor;United States;Variant;Vascular Diseases;whole genome;Williams Syndrome;Work

PROJECT_TITLE: Modifiers of elastin arteriopathy


PI_NAMEs: CAMPBELL-WASHBURN, ADRIENNE  (contact)

PROJECT_TERMS: cardiac magnetic resonance imaging;Cardiopulmonary;Cardiovascular system;Catheterization;Collaborations;Computer software;Development;Devices;Diagnostic;Electrocardiogram;Environment;Fluoroscopy;Goals;heart imaging;Heating;Image;image guided;imaging approach;imaging modality;Imaging Techniques;improved;industry partner;innovative technologies;Intervention;Ionizing radiation;lung imaging;magnetic field;Magnetic Resonance Imaging;metallicity;Methods;minimally invasive;novel;Patients;Performance;Predisposition;Procedures;real-time images;reconstruction;Roentgen Rays;soft tissue;System;Techniques;Testing;Therapeutic;Time;Visualization

PROJECT_TITLE: Innovative Technology for MRI Guided Procedures


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Hematology;Human Genome;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

PI_NAMEs: THEIN, SWEE LAY  (contact)

PROJECT_TERMS: 10 year old;2 year old;Affect;African ancestry;alpha-Thalassemia;Basic Science;biobank;Biochemical;Biological Specimen Banks;Blood;Blood Transfusion;Bone Marrow Transplantation;Bone necrosis;Brain;Brain Infarction;brain magnetic resonance imaging;Caring;Cell Culture Techniques;Cell Separation;Cephalic;cerebrovascular;Cerebrovascular Disorders;Characteristics;Child;Clinical;clinical center;Clinical Data;Clinical Management;clinical phenotype;clinical predictors;comorbidity;Complication;Databases;Development;Disease;disease model;Disparate;Early Intervention;Eligibility Determination;Enrollment;exome sequencing;experience;extend lifespan;extracellular;Fetal Hemoglobin;follow-up;Future;General Anesthesia;Generations;Genes;Genetic;Genetic Markers;genetic variant;Genome Scan;genome sequencing;genome wide association study;Genomics;Genotype;Health system;Healthcare;Heart;Hematological Disease;Hemoglobin concentration result;high risk;Hospitals;Human;Impaired cognition;improved;improved outcome;In Vitro;Individual;Infarction;information gathering;Informed Consent;Inherited;Kidney;Life;Liver;Lung;lung injury;Medical;middle cerebral artery;Minority;Molecular;Morbidity - disease rate;Natural History;novel;novel therapeutics;Nucleic Acids;Organ;Other Genetics;Outcome;Patients;Performance;Phenotype;Population;prevent;Procedures;Process;Protocols documentation;Public Health;Quality of life;Recording of previous events;renal damage;Research;Research Methodology;Research Project Grants;research study;Sampling;Scanning;Schools;Science;Severities;Severity of illness;Sickle Cell;Sickle Cell Anemia;Single Nucleotide Polymorphism;Site;Stroke;stroke incidence;Stroke prevention;stroke risk;Technology;therapy outcome;Transfusion;Translational Research;United States National Institutes of Health;Variant;Vascular Diseases;Washington;whole genome

PROJECT_TITLE: Studies of the Natural History of Sickle Cell Disease


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: ALTAN-BONNET, NIHAL  (contact)

PROJECT_TERMS: 2019-nCoV;Adaptive Immune System;Aerosols;Animals;Antigen Presentation;Architecture;Area;Astrovirus;Biophysics;Breast Feeding;Cell Physiology;Cells;Cellular biology;Cooperative Behavior;Coronavirus;COVID-19 pandemic;COVID-19 patient;Cytolysis;Diagnostic;Disabled Persons;Docking;Economics;Enteral;Enterovirus;Enterovirus 68;Environment;Enzymes;Evolution;Exhibits;Exocytosis;extracellular vesicles;Feces;Gastrointestinal tract structure;Genetic Transcription;Golgi Apparatus;Health;Hepatitis C;Human;Human poliovirus;Image;Immune response;Immune System Diseases;Individual;Infant;infant infection;Infection;Inflammatory;Innate Immune System;Intestines;Investigation;Life Cycle Stages;lipid metabolism;Lipids;live cell microscopy;Lung;lysosomal proteins;Lysosomes;Mammary gland;Membrane;Messenger RNA;Molecular;Morbidity - disease rate;mortality;Mothers;mutant;Norovirus;Oral;pandemic disease;particle;pathogen;Pathway interactions;peer;Persons;Pharmacologic Substance;Phosphatidylinositols;Phosphotransferases;Population;Process;protein degradation;Public Health;recruit;response;Rhinovirus;RNA Viruses;Rotavirus;Route;Saliva;Salivary;salivary assay;Salivary Glands;Sanitation;SERPINA4 gene;Side;skills;Small Intestines;small molecule;suckling;System;tool;Translations;transmission process;Travel;Universities;Variant;Vesicle;Viral;Viral Physiology;Viral Proteins;viral transmission;Virion;virology;Virulent;Virus;Virus Assembly;Virus Replication;Water

PROJECT_TITLE: Virus Egress Pathways


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: LEE, JENNIFER  (contact)

PROJECT_TERMS: Adopted;alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid Fibrils;amyloid formation;Amyloid Proteins;Amyloidosis;Binding;Biological;Biological Process;Cell Nucleus;Cell Physiology;Cells;Chemicals;Coupled;Couples;Coupling;Deposition;Disease;Environment;Exclusion;Extracellular Space;Frequencies;Goals;Human;Hydration status;Image;imaging modality;imaging probe;In Vitro;insight;interest;Intervention;Investigation;Lewy Bodies;Lipids;Liquid substance;Maps;Measures;Methods;Microscope;Microscopy;Molecular;Molecular Conformation;Molecular Target;Motion;Nature;Nerve Degeneration;Neurofibrillary Tangles;novel;novel strategies;Nucleotides;Organ;Parkinson Disease;Pathogenicity;Pathologic;Peptide Hydrolases;Phase;Polymorph;polypeptide;Population;Process;protein aggregation;Protein Conformation;Proteins;Raman Spectrum Analysis;Reporting;Resistance;Resolution;Running;Secondary Protein Structure;Site;Specificity;spectrograph;spectroscopic survey;Spectrum Analysis;Structure;Techniques;Tissues;vibration;Visualization;Water;Work

PROJECT_TITLE: Raman Spectroscopic Studies of Amyloids


NIH_SPENDING_CATS: Bioengineering;Neurosciences

PI_NAMEs: JIANG, JIANSEN  (contact)

PROJECT_TERMS: 3-Dimensional;Bicarbonates;Binding;Borates;Boron;Cell Physiology;Characteristics;Classification;computerized data processing;Cryoelectron Microscopy;Data Set;density;Detergents;Development;dimer;Disease;Drug Carriers;Drug Interactions;Drug Transport;experimental study;Family;Goals;Histamine;improved;Integral Membrane Protein;Lead;Ligands;Lipids;Masks;Mediating;Membrane;Membrane Lipids;Membrane Proteins;Membrane Transport Proteins;Metabolite Interaction;method development;Methods;Micelles;microscopic imaging;Molecular Conformation;Molecular Weight;monoamine;Nature;Neurotransmitters;new therapeutic target;Noise;particle;Pharmaceutical Preparations;Plants;prevent;programs;Proteins;Publishing;reconstruction;Regulation;Reporting;Research;Resolution;side effect;Signal Transduction;smoothened signaling pathway;solute;Structure;Synaptic Vesicles;Testing;Therapeutic;Transmembrane Domain;vesicular monoamine transporter 2;Water;WNT Signaling Pathway;X-Ray Crystallography

PROJECT_TITLE: Structural studies of membrane proteins using high-resolution cryo electron microscopy


NIH_SPENDING_CATS: Clinical Research;Hematology;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

PROJECT_TERMS: Acute;Acute Pain;Affinity;Alloimmunization;Binding;Biological Availability;Blood;Bone Marrow Transplantation;Cell membrane;Clinical;Complication;curative treatments;Data;Deoxygenated Sickle Hemoglobin;diphosphoglycerate;Disease;Dissociation;Dose;Drug Kinetics;Drug Targeting;Enzyme Activators;enzyme substrate;Enzymes;Erythrocytes;Event;FDA approved;Fetal Hemoglobin;Frequencies;Glycolysis;Hemoglobin;Histocompatibility;Hospitalization;Human;hydroxyurea;in vivo;Iron Overload;Laboratory Study;novel;Oral;Organ;Oxygen;Pain;Pathway interactions;Pharmacodynamics;Phosphoenolpyruvate;Pilot Projects;polymerization;Polymers;pre-clinical;prescription opioid;Process;Production;Pyruvate;Pyruvate Kinase;pyruvate kinase deficiency;Reaction;Reporting;Risk;Role;Safety;Sickle Cell;Sickle Cell Anemia;sickle cell crisis;Sickle Cell Trait;sickling;small molecule;Source;Supportive care;Syndrome;System;Testing;therapeutic target;Transfusion

PROJECT_TITLE: A Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of escalating multiple oral doses of AG-348 in subjects with stable sickle cell disease


NIH_SPENDING_CATS: Genetics;Hematology;Human Genome;Infectious Diseases;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

PROJECT_TERMS: Acute;Adenosine Triphosphate;Affinity;African;African American population;Anemia;Binding;Biochemical;Biological Assay;Blood specimen;Cell membrane;Chronic;Clinical;Clinical Research;cohort;Deoxygenated Sickle Hemoglobin;diphosphoglycerate;disease phenotype;disorder control;DNA;enzyme substrate;Enzymes;Erythrocytes;Ethnic Origin;Falciparum Malaria;Gene Frequency;Genes;Genetic;Genetic Determinism;genetic variant;Genetic Variation;Genome;Genomic DNA;Genotype;Geographic Locations;Glycolysis;Goals;Hemoglobin;Hemolytic Anemia;Individual;Introns;loss of function;Malaria;metabolomics;Mutation;National Heart, Lung, and Blood Institute;orlistat;Oxygen;Pathology;Pathway interactions;Patients;Phase;Phenotype;Phosphoenolpyruvate;Piezo 1 ion channel;polymerization;Polymers;Population;Production;Proteins;Proteomics;Protocols documentation;Pyruvate;Pyruvate Kinase;pyruvate kinase deficiency;Quantitative Reverse Transcriptase PCR;recruit;Reporting;response;RNA Sequences;Sampling;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;SLC2A1 gene;Source;Syndrome;therapeutic target;trait;transcriptome;transcriptome sequencing;Variant

PROJECT_TITLE: Genotype -Phenotype Correlation of PKLR Variants with Pyruvate Kinase, 2,3-Diphosphglycerate and ATP Activities in Red Blood Cells of Patients with Sickle Cell Disease


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Hematology;Human Genome;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Acute;Address;Anemia;Antibodies;Anticoagulation;Antisickling Agents;assay development;Autologous;Basic Science;Biochemical;Biological Assay;biological development;Biological Markers;Biology;Biotin;bisulfite sequencing;Blood;Blood Platelets;Blood specimen;Blood Vessels;Bone Marrow;CD34 gene;Cell Adhesion Molecules;cell free DNA;Cell Volumes;Cells;Clinical Research;Clinical Trials;Coagulation Process;Collaborations;Collection;comparison control;cytokine;Data;density;Density Gradient Centrifugation;Development;Disease;DNA;endothelial dysfunction;Engraftment;Equilibrium;Erythrocytes;Ethnic Origin;experimental study;extracellular;extracellular vesicles;Fiber;Flow Cytometry;Functional disorder;Gene Expression Profiling;Gene Transfer;Genetic;genetic approach;genome sequencing;granulocyte;Half-Life;healthy volunteer;Hematopoietic Stem Cell heterogeneity;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobin;Human;Image;In Vitro;in vitro Assay;Individual;Inflammation;inter-individual variation;Intramural Research Program;Isomerase;Kinetics;Label;Laboratories;Laboratory Chemicals;laboratory development;Laboratory Research;Libraries;life span;luminescence;Marrow;Measurement;Measures;Methodology;Methods;Mitochondrial DNA;Modification;Molecular;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;neutrophil;Neutrophil Activation;Oxygen;Pathogenesis;Pathologic Processes;Patients;PF4 Gene;phase 2 study;Physics;Plasma;Plasma Proteins;Platelet aggregation;Polymerase Chain Reaction;Preparation;progenitor;Protein Disulfide Isomerase;protein expression;protein function;Protocols documentation;Research;research and development;research study;Research Support;Reticulocytes;Saliva;sample collection;Sampling;Serum;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;Sickle Hemoglobin;sickling;single-cell RNA sequencing;small molecule inhibitor;Specimen;Standardization;Testing;Thermodynamics;Thrombospondins;Urine;Variant;Vascular Diseases;vaso-occlusive crisis;Venous Thrombosis;volunteer;Whole Blood;whole genome

PROJECT_TITLE: Human Specimen Collection to Support Basic and Clinical Research


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Neurodegenerative;Nutrition;Prevention

PI_NAMEs: REMALEY, ALAN THOMAS (contact)

PROJECT_TERMS: Age related macular degeneration;Amendment;Animal Model;Animals;bench to bedside;Biological Markers;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Clinical Protocols;Clinical Trials;Dietary Supplementation;Disease;Energy Metabolism;fatty acid supplementation;Fatty Acids;Fish Oils;Goals;Grant;Health;Hypertriglyceridemia;improved;Length;Lipids;Lipoproteins;Measures;Metabolism;Patient Recruitments;Patients;Plasma;Polyunsaturated Fatty Acids;Publishing;recruit;Role;Supplementation;Testing;Triglycerides;United States National Institutes of Health;Very Long Chain Fatty Acid;Vision

PROJECT_TITLE: Role of fatty acids in health and disease.


PI_NAMEs: AKERA, TAKASHI  (contact)

PROJECT_TERMS: Affect;Alleles;Anaphase;Aneuploidy;Animals;Behavior;Biological;Biology;Cell division;Cell Nucleus;Cells;Centromere;Chimeric Proteins;Chromosome 2;Chromosome Condensation;Chromosome Segregation;Chromosome Structures;Chromosomes;Collaborations;Complex;condensin;CRISPR/Cas technology;Defect;Diploidy;DNA Sequence;Drosophila genus;egg;Elements;Embryo;Eukaryota;Evolution;experimental study;Failure;Female;Female sterility;Fertility;Fertility Disorders;fitness;Fluorescent in Situ Hybridization;Gene Frequency;Genes;Genetic;Genetic Diseases;genetic element;Genome;Germ Cells;Germ Lines;Goals;Haploidy;House mice;Human;Hybrids;Image;Infertility;insight;Laws;Link;live cell imaging;Maize;Mammals;Meiosis;Methods;Microtubules;Molecular;Mus;National Institute of Child Health and Human Development;Nature;next generation;Oocytes;Parents;Phenotype;Physical condensation;Pisum sativum;Population;prevent;Process;Production;Reproduction;reproductive;Rest;Rod;rosin;segregation;Selfish DNA;Selfish Genes;sex;Sexual Reproduction;Shapes;Stretching;System;Techniques;transmission process;Visualization;Work

PROJECT_TITLE: Chromosome Dynamics and Evolution


PROJECT_TERMS: 3-Dimensional;Algorithms;Award;Breathing;California;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;Collaborations;Computer software;Data;denoising;Development;Disease;Feedback;Goals;Grant;healthy volunteer;Image;imaging modality;improved;Industry;Institution;Journals;Lung;lung imaging;Magnetic Resonance Imaging;Medical center;Methods;Morphology;novel;Patients;Performance;Physiologic pulse;Prize;Procedures;real-time images;reconstruction;Research Methodology;Research Personnel;Scanning;symposium;System;Technology;Translating;Universities;Water;Work

PROJECT_TITLE: Development of high-performance low field MRI technology