NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Many developmental and adult cases of neural injury and degeneration such as Alexander disease, multiple sclerosis and Alzheimer’s disease are associated with alterations in the development of glia (gliogenesis). However, studying gliogenesis using classical techniques is labor-intensive and tedious, as gliogenesis displays large variances in its spatial and temporal outputs. To address this challenge, we will develop a technological platform that enables rapid and unbiased analysis of histological tissues with multiple labeled elements to reveal effects of genetic manipulation on gliogenesis.

PI_NAMEs: GREENBAUM, ALON  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Learning;Address;Adoption;Adult;Alexander Disease;Alzheimer's Disease;Anatomy;Artificial Intelligence;Atlases;Biological;Biology;Blood - brain barrier anatomy;Brain;Brain Injuries;Butterflies;Calibration;cell type;Cells;Central Nervous System;central nervous system injury;Classification;Clinical;CNS degeneration;Collection;Color;Communities;computational platform;Data;Data Analyses;deep learning;design;Detection;Development;Disease;Elements;Ensure;Exhibits;Fluorescence Microscopy;Future;Genes;Genetic;genetic approach;genetic manipulation;Genetic Models;gliogenesis;Goals;graphical user interface;Histologic;Histology;Image;imaging platform;improved;in vivo;innovation;Interdisciplinary Study;Label;large datasets;learning network;Life;Light;Lighting;Manuals;Maps;Methods;Microscope;microscopic imaging;Modeling;Morphology;mouse genetics;Multiple Sclerosis;Mus;Myelin;Nerve Degeneration;nerve injury;Neurodegenerative Disorders;neurogenesis;Neuroglia;Neurons;new technology;new therapeutic target;novel;novel strategies;open source;Optics;Organ;Output;Performance;Phase;Phenotype;physical model;Play;Procedures;Production;Prosencephalon;Public Health;Publications;Publishing;Recommendation;Regenerative capacity;Regenerative research;Resolution;Sampling;Signal Transduction;software development;Structure;success;Synaptic Transmission;System;Techniques;Technology;technology platform;Testing;Time;tissue processing;Tissues;Training

PROJECT_TITLE: Imaging and computational platform for integrated analysis of biodata

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Guided by a decade of experience the Center for Undiagnosed Diseases at Stanford, a member site of the Undiagnosed Diseases Network, will continue to develop and implement innovative, effective, and sustainable strategies to diagnose the undiagnosed of all backgrounds. Our Center will continue to bring Stanford’s expertise in technology development, genomic and multi-omic data analysis, stem cell biology, and translational research to the team-based diagnosis and care of diverse individuals with undiagnosed diseases. We will build and carefully study deep collaborations with community partners to promote the participation of the underserved and integrate advanced evaluation of the undiagnosed with routine clinical practice while advancing the scientific mission of the Undiagnosed Diseases Network.

PI_NAMEs: BERNSTEIN, JONATHAN ADAM;TABOR, HOLLY K;WHEELER, MATTHEW THOMAS (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;Bioinformatics;California;Candidate Disease Gene;Caring;Cellular Assay;Child Health;Clinical;clinical care;Clinical Pathways;clinical phenotype;clinical practice;clinical research site;cohort;Collaborations;Communities;community advisory board;community building;community collaboration;community empowerment;Community Health Services;community partners;community partnership;County;Data;Data Analyses;design;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic technologies;diagnostic value;Disease;Enrollment;Evaluation;evidence base;exhaust;experience;falls;Family;Feedback;Funding;genome sequencing;genomic data;Genomics;health disparity;Health system;Healthcare;high dimensionality;improved;Individual;Informatics;innovation;Institution;interdisciplinary collaboration;Investigation;large language model;Leadership;Medical;member;Methodology;Methods;Mission;model organism;Molecular;molecular diagnostics;Monitor;Multiomic Data;multiple omics;New Territories;novel;Outcome;Participant;Patient Representative;Patients;Phase;Procedures;Process;programs;Proteomics;Protocols documentation;Provider;Publishing;rare condition;Rare Diseases;recruit;Research;research clinical testing;Research Personnel;Research Support;Resources;Scientific Advances and Accomplishments;screening;Site;social service provider;Societies;standard of care;stem cell biology;success;technology development;tool;transcriptomics;Translational Research;underserved community;Underserved Population;United States National Institutes of Health;Universities;Update;Validation;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  In all vertebrate embryos, the neural crest gives rise to the sensory, autonomic and enteric nervous system, craniofacial skeleton and melanocytes of the skin. Not only does the neural crest have the capacity to form an amazing number of embryonic cell types, but also neural crest stem cells persist in adult tissue. Because neural crest cells are involved in a variety of birth defects such as Hirschsprung’s disease, cleft palate and various types of cancers, like melanoma and neuroblastoma, the results of this proposal regarding evolution of neural crest cell differentiative ability will provide important understanding of the normal development of these cells that can later lead to disease states.

PI_NAMEs: BRONNER, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Amaze;Anterior;Autonomic nervous system;Brain;cancer type;cell type;Cells;Chick;Cleft Palate;Complex;Congenital Abnormality;Congenital Megacolon;Coupled;craniofacial;Data Set;detection method;Development;Disease;embryo cell;Enteric Nervous System;Evolution;Fluorescence;Ganglia;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genes;Genomics;Heterogeneity;In Situ Hybridization;insight;Intestines;Jaw;Lampreys;Lateral;Lead;Length;Maps;melanocyte;Melanoma;neural;Neural Crest;Neural Crest Cell;Neuroblastoma;Neurons;novel;Oligonucleotides;parent grant;Peripheral;Play;Predatory Behavior;Reaction;Resolution;Role;Sensory;single-cell RNA sequencing;Skeleton;Skin;stem cells;Testing;Tissues;transcriptome sequencing;transcriptomics;Validation;vertebrate embryos;Vertebrates;Visualization;Zebrafish

PROJECT_TITLE: Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolution


ADMINISTERING_IC: HL

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE The CLIMAte-Related Exposures, Adaptation, and Health Equity (CLIMA) Center based at the University of Southern California aims to build transdisciplinary science capacity to advance community-engaged, solution- oriented climate change, adaptation, and health research and to inform climate action policies for health equity. CLIMA will develop novel methods to characterize climate-related exposures such as urban heat islands, wildfire smoke and compound climate events, their impact on cardiovascular health and resilience across the life course, and the role of adaptation strategies (air conditioning, greening interventions for shade), and system and human vulnerability (power outages, social vulnerability). California's diverse communities and array of climate action and health equity policies provide an optimal setting to learn early lessons on real-life effectiveness, co-benefits, and gaps in adaptation strategies that communities and policy makers can use to protect the most vulnerable and strengthen climate change resiliency.

PI_NAMEs: HABRE, RIMA  (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Acceleration;Acute;Adult;Age;aged;Air Conditioning;Air Pollution;allostatic load;Biological;Biostatistical Methods;Blood Pressure;California;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cessation of life;Child;Childhood;Climate;climate adaptation;climate change;climate impact;climate zone;climate-related exposures;climate-related health;Communication;Communities;community based participatory research;community engagement;community partners;Complex;Computerized Medical Record;Data;Dependence;design;Droughts;Education;Effectiveness;Emergency Situation;environmental justice;Event;Exposure to;extreme heat;Fostering;Frequencies;Global Warming;Goals;hazard;Health;health assessment;health determinants;health equity;Health Policy;Heart failure;heat island;Heat Stress;Heat Waves;hospital readmission;Hospitalization;Hospitals;Household;Human;Individual;innovation;intergenerational;Intervention;Lead;Learning;Life;Life Cycle Stages;Link;Los Angeles;Measures;method development;Methods;Mission;Modeling;Monitor;Neighborhoods;novel;Outcome;Particulate Matter;Pattern;Pediatric Hospitals;physical process;Policies;Policy Maker;Population Heterogeneity;programs;promote resilience;Public Health;Pulse Rates;Recording of previous events;Research;research and development;Research Infrastructure;Research Project Grants;resilience;resilience factor;Risk;Role;Science;Scientist;Sentinel;Smoke;social;Social Adjustment;social vulnerability;spatiotemporal;Statistical Methods;System;Temperature;Translational Research;Trees;Universities;Wildfire;young adult;Youth

PROJECT_TITLE: CLIMAte-related Exposures, Adaptation, and Health Equity (CLIMA) Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-K (C2)]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Acceleration;Advisory Committees;Age;burden of illness;California;career;career development;Climate;climate change;climate science;climate-related exposures;climate-related health;clinical application;Communication;Communities;Community Actions;community advisory board;community engagement;Community Health;community organizations;Data;data pipeline;disability;Educational workshop;Effectiveness;Electronic Mail;Ensure;Environmental Health;environmental justice;Epidemiology;Event;Fertilization;Fostering;Grant;Health;health communication;health equity;Health equity research;Health Policy;Health Sciences;Incubated;Individual;Infrastructure;innovation;Institution;interdisciplinary collaboration;intergenerational;International;knowledge base;Learning;Life;Medical;meetings;member;method development;Mission;Modeling;Monitor;Needs Assessment;organizational structure;Outcome;Periodicals;Play;Policies;Policy Maker;Population;Productivity;Program Development;programs;Public Health;Publications;Recommendation;Records;Reporting;Reproducibility;Research;research and development;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;resilience;Resources;Role;Science;Scientist;Series;social media;Statistical Methods;success;symposium;Talents;Translational Research;Translations;United States National Institutes of Health;Universities;Vision;web site;webinar;Youth

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Patient Safety;Social Determinants of Health

PI_NAMEs: GARCIA, ERIKA  (contact)

PROJECT_TERMS: access disparities;Address;Adoption;Affect;Age;Air Conditioning;air filtration;Air Pollution;California;Characteristics;Climate;climate adaptation;climate change;climate impact;climate policy;climate-related exposures;climate-related health;Communities;community intervention;comorbidity;Computerized Medical Record;cooling centers;Data;data fusion;Data Set;decrease resilience;Disparity;Effectiveness;Ensure;Equity;Ethnic Origin;Event;Exposure to;extreme heat;Failure;fine particles;Forestry;Future;Generations;Green space;hazard;Health;Health Care Reform;health disparity;health equity;Heart failure;heat island;Heterogeneity;hospital readmission;Hospitalization;Household;Human;Impairment;indexing;Individual;Inequity;innovation;Intake;Intervention;Joints;Knowledge;Length of Stay;Liquid substance;Location;Los Angeles;Methods;Morbidity - disease rate;Neighborhoods;novel;Outcome;Patient Readmission;Patients;Penetration;Physiologic Thermoregulation;Policies;Population Heterogeneity;Predisposition;programs;Proxy;Public Health;Race;Research;Research Project Grants;resilience;Risk;Role;Safety;secondary outcome;Sentinel;sex;Smoke;social vulnerability;sociodemographics;Socioeconomic Status;Statistical Methods;Stress;success;Time;tool;Universities;urban area;vulnerable community;Vulnerable Populations;Wildfire

PROJECT_TITLE: The role of vulnerability and adaptation on the effects of co-occurring heat, air pollution, and wildfire on heart failure hospitalizations


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PI_NAMEs: FARZAN, SHOHREH F (contact)

PROJECT_TERMS: Address;Adult;adverse outcome;Age;Air Pollution;allostasis;allostatic load;Anxiety;Biological;Blood Pressure;Blood Vessels;Body System;Buffers;California;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Carotid Artery Injuries;Child;Child Health;Childhood;Chronic;Chronic stress;Climate;climate adaptation;climate change;climate impact;climate-related exposures;cohort;Communities;cooling centers;decrease resilience;Development;Disadvantaged;Disease;emerging adult;Environmental Exposure;environmental stressor;Evaluation;Event;experience;Exposure to;follow-up;Goals;hazard;Health;health assessment;health equity;heat island;Heat Stress;Immune;indexing;Individual;Joints;late life;Life Cycle Stages;Link;Measures;Mental Health;Metabolic;Modeling;mortality;Neighborhoods;Neurosecretory Systems;Outcome;Participant;personalized screening;Physiology;Play;promote resilience;public health priorities;Pulse Rates;resilience;resilience biomarker;response;Risk;Role;screening;Smoke;social vulnerability;Stress;stressor;System;therapy design;Time;Trees;ultrasound;vascular injury;Vulnerable Populations;Wildfire;young adult;Youth

PROJECT_TITLE: The Role of Adaptation and Resilience in a Changing Climate: Cardiovascular Risk and Allostatic Load Among Youth


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOHNSTON, JILL E (contact)

PROJECT_TERMS: Address;Adult;Adverse effects;Advocate;Age;Air;Air Pollution;Area;Behavior;Benchmarking;California;cardiovascular health;Cities;Climate;climate change;climate crisis;climate data;climate impact;climate-related exposures;climate-related health;Collaborations;Color;Communication;Communication Methods;Communications Media;Communities;community academic partnership;Community Actions;community center;community engagement;community organizations;community science;coping;Country;design;Development;dissemination strategy;Educational workshop;Environmental Health;environmental health disparity;environmental justice;Equity;Ethnic Origin;Evaluation;experience;Exposure to;Face;Family;Fostering;Frequencies;Goals;Health;health disparity populations;health equity;Health Hazards;health literacy;Health Status;Heat Waves;Home;Immigrant;improved;innovation;intergenerational;Justice;Knowledge;Laws;Location;Los Angeles;marginalized community;Measures;method development;Microclimate;Mission;Modeling;Neighborhoods;novel;Online Systems;Particulate Matter;people of color;pollutant;Population Heterogeneity;Poverty;Printing;programs;protective behavior;Psychosocial Stress;Public Policy;Race;Research;research and development;Research Personnel;Research Project Grants;resilience;Resources;Science;Science Policy;Series;Severities;social disparities;social media;socioeconomics;Structure;success;System;Training;Treatment/Psychosocial Effects;Universities;uptake;urban area;Variant;Visualization;Wildfire;Youth

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: SANDERS, KELLY TWOMEY (contact)

PROJECT_TERMS: Acceleration;Air Conditioning;Air Movements;Area;Burn injury;California;cardiovascular health;Climate;climate adaptation;climate change;climate forcing;climate impact;climate zone;climate-related exposures;climate-related health;Communities;community engagement;Complex;cost;Coupled;Data;Dependence;Droughts;Effectiveness;Electricity;Ensure;Environmental Exposure;environmental justice;Equilibrium;Event;Face;Floods;Frequencies;Future;Global Warming;greenhouse gases;hazard;Health;health equity;Health Policy;heat island;Heat Stress;Heat Waves;high risk;High temperature of physical object;Household;Human;improved;indexing;Intervention;Lead;Life;Life Cycle Stages;Measures;method development;Methods;middle age;Modeling;Natural Disasters;Nature;neighborhood disadvantage;older adult;Pattern;Penetration;Policies;Policy Maker;Population Heterogeneity;Preventive measure;Readiness;Recovery;Research;research and development;Research Project Grants;resilience;Resolution;response;Risk;Safety;Smoke;social vulnerability;spatiotemporal;Surface;System;Temperature;Time;Trees;Universities;Vulnerable Populations;warm temperature;Weather;Wildfire;Youth

PROJECT_TITLE: Methods Development Research Core


NIH_SPENDING_CATS: Brain Disorders;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Lung;Natural Products;Pediatric

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: NARRATIVE Pulmonary complications are the main cause of hospitalizations in children and adults with Down Syndrome, often presenting with upper airway diseases such as tracheobronchial malacia and airway obstruction with wheezing, particularly in babies and children. Therefore, understanding early, perinatal factors leading to lung disease in neonates and children with DS becomes clinically relevant, innovative and transformative, with potential for substantial lifelong impact in a highly vulnerable population with major unmet medical needs. DS is known as a progeric syndrome, exhibiting increased cellular senescence mainly described in brain cells, which may also impact lung disease in early infancy, the focus of our proposed studies.

PI_NAMEs: AL-ALAM, DENISE  (contact);PABELICK, CHRISTINA MARIA

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Adult;Aging;Airway Disease;airway muscle;airway obstruction;airway remodeling;Alzheimer's Disease;Autoimmune Diseases;beta-Galactosidase;Birth;brain cell;Cell Aging;Cell Count;Cell Cycle Arrest;Cells;Characteristics;Child;Childhood;Clinical Trials;clinically relevant;Craniofacial Abnormalities;Dasatinib;Data;Disease;DNA Damage;Down's Syndrome;Elements;endoplasmic reticulum stress;Exhibits;Extracellular Matrix;fetal;Fetal Lung;Fibrosis;fisetin;Flavonoids;Growth;Healthcare;Heart Diseases;Hospitalization;Human;human fetal lung tissue;immune clearance;in utero;Individual;infancy;Inflammatory;innovation;Interferons;Intervention;kinase inhibitor;Life;Link;Live Birth;Lung;Lung Diseases;Maintenance;Mediating;Medical;Mesenchymal;mitochondrial dysfunction;Modeling;Morphology;Muscle Tonus;Neonatal;neonatal lung disease;neural;novel strategies;novel therapeutics;Oxidative Stress;paracrine;Pathogenesis;Pathway interactions;Perinatal;perinatal period;Pharmaceutical Preparations;Phenotype;postnatal;Pregnancy;premature;prenatal;Progeria;Proliferating;Pulmonary Fibrosis;Pulmonary Hypertension;pulmonary hypoplasia;Quercetin;repaired;response;Role;Sampling;senescence;senolytics;senomorphic;Signal Transduction;Slice;Strawberries;Structure of parenchyma of lung;Syndrome;Testing;therapeutically effective;Time;Tissues;Tracheobronchial;Vulnerable Populations;Wheezing

PROJECT_TITLE: Cellular Senescence in Trisomy 21 lung disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Congenital Structural Anomalies;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE Coronary artery disease (CAD) continues to be a leading cause of death in the United States despite lifesaving drugs and procedures like angioplasty and bypass surgery. We propose to study the genetics of human coronary artery structural variation to discover the biological mechanisms behind coronary artery formation and the development of naturally occurring bypass arteries termed `collaterals'. Ultimately, our goal is to use this information to develop new pharmacological or gene therapies that promote arterial growth to improve and lengthen the life of those afflicted with CAD.

PI_NAMEs: ASSIMES, THEMISTOCLES LEONARD (contact);RED-HORSE, MARY ;WALDO, STEPHEN

PROGRAM_OFFICER_NAME: FLEG, JEROME L

PROJECT_TERMS: acute coronary syndrome;Adult;advanced disease;African;Anatomy;Angioplasty;Aorta;Arteries;Awareness;biobank;Biological;Biological Assay;Bypass;Candidate Disease Gene;Cardiology;Cardiovascular Diseases;Cardiovascular system;Catheterization;causal variant;Cause of Death;Cellular biology;Classification;Clinical;Complementary therapies;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;Coronary Vessel Anomalies;Data;Data Set;design;Development;Disease;electronic health record system;Embryonic and Fetal Development;Epidemiology;epigenetic marker;European;Fetal Development;Foundations;gene therapy;Genes;Genetic;Genetic Determinism;genetic epidemiology;genetic manipulation;Genetic Polymorphism;Genetic study;genetic variant;genome wide association study;genomic locus;Genomics;Goals;Growth;Healthcare Systems;Heart Injuries;Heritability;Hispanic Americans;Human;Human Genetics;human induced pluripotent stem cells;human population genetics;human population study;improved;Individual;Injury;innovation;Integrated Health Care Systems;Intervention;Investigation;Investments;Knowledge;Left;Life;Maps;Mechanics;Medical;Medicine;Meta-Analysis;Methods;Modeling;Molecular;mortality;mouse genetics;multidisciplinary;Natural Language Processing;Natural regeneration;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Participant;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Population Genetics;Population Heterogeneity;pre-clinical;Procedures;programs;Property;regenerative cell;Regenerative pathway;Registries;Research;revascularization;Risk;Series;statistics;Stromal Cell-Derived Factor 1;success;Susceptibility Gene;Testing;Translational Research;United States;Variant;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Intersecting clinical, genomic, and experimental investigation to understand the mechanisms and impact of coronary artery patterning

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: LITTLE ROCK

ORG_NAME: ARKANSAS CHILDREN'S HOSPITAL RES INST

ORG_STATE: AR

PHR: Invasive fungal infection caused by Aspergillus fumigatus is a leading cause of death for patients with lowered immune systems. Despite this high mortality, the fundamental mechanism of how A. fumigatus grows and invades the host tissue is not understood and this knowledge is critical to improving therapeutic treatment. Hyphal growth is crucial for A. fumigatus invasive disease and the proposed research will define the mechanism of how a critical calcineurin signaling pathway interacts with other proteins to regulate fungal growth, antifungal response, and disease.

PI_NAMEs: JUVVADI, PRAVEEN RAO (contact);STEINBACH, WILLIAM J

PROGRAM_OFFICER_NAME: LIU, BAOYING

PROJECT_TERMS: Affinity;Animal Model;anti-fungal agents;Aspergillosis;Aspergillus fumigatus;Azole resistance;Azoles;beta-Glucans;Binding;Biochemical;biological adaptation to stress;Biological Assay;Calcineurin;Cause of Death;Cell membrane;Cell Physiology;Cell Wall;clinically relevant;combat;comparative;Complement;Complex;Crystallization;Data;Death Rate;Defect;Dependence;Disease;Drug resistance;echinocandin resistance;Effector Cell;Ergosterol;Fluorescence;Fungal Drug Resistance;fungus;Future;Genetic;genetic approach;Genetic study;Genetic Transcription;Glucosylceramides;Growth;Guidelines;Immune system;Immunocompromised Host;improved;In Vitro;in vivo;Infection;inhibitor;Invaded;Knowledge;lipidomics;Lipids;Membrane;membrane synthesis;Modeling;Molecular;molecular dynamics;molecular modeling;mortality;mouse model;Mus;mutant;Mutation;Mycoses;novel;novel strategies;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphatidylglycerols;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Play;Predisposition;Process;promoter;Protein Dephosphorylation;Proteins;Proteome;Proteomics;Recommendation;Regulation;Research;Resistance;resistant strain;response;Role;Scanning;screening;Signal Pathway;Site;Stress;Structure;Testing;Therapeutic;Time;Tissues;transcription factor;Transcriptional Regulation;Translational Activation;translational potential;Validation;Virulence

PROJECT_TITLE: Calcineurin Control over Aspergillus Fumigatus Antifungal Response Mechanisms

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: The proposed research will significantly advance our understanding of the cellular and molecular pathways, and cell-specific transcriptomic profiles contributing to the neurobiological basis of major depressive disorder. Through a better understanding of the mechanisms of depressive illness, we may be one step closer to developing novel treatment strategies and personalize interventions. The proposed project will be representative of both Caucasians and African American individuals and will be sufficiently powered to identify molecular processes that are sex specific.

PI_NAMEs: GOES, FERNANDO SAMPAIO;HYDE, THOMAS MICHAEL (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;Affect;African American;African American population;Amygdaloid structure;Anterior;anti-depressive agents;Area;association cortex;Autopsy;Biological;Biological Assay;Bipolar Disorder;Brain;brain cell;Brain region;burden of illness;caucasian American;Cell Nucleus;cell type;Cells;Chromosome Mapping;cingulate cortex;cognitive function;cohort;convolutional neural network;Data;deep learning;depressive symptoms;Diagnostic;Disease;Disease remission;Emotional;Emotions;Etiology;European;Female;Functional disorder;functional genomics;Gatekeeping;Gene Expression;gene network;Gene set enrichment analysis;Genes;Genetic;Genetic Transcription;genome wide association study;genome-wide;genomic locus;Genomics;Hippocampus;Human;Human Resources;Impairment;Individual;innovation;Investigation;Ligands;Link;Machine Learning;Major Depressive Disorder;Maps;Mediating;Mental Depression;Mental disorders;Metabolic;Modeling;Molecular;Mood Disorders;mood regulation;Moods;Morbidity - disease rate;multi-ethnic;negative mood;Negative Valence;Network-based;neural network;Neurobiology;Neurosciences;novel;Outcome;Pathway interactions;personalized intervention;Play;Process;Protocols documentation;Psychopathology;Pyramidal Cells;Quantitative Genetics;Quantitative Trait Loci;receptor;Research;Research Domain Criteria;Resolution;Resources;response;Role;Sample Size;Sampling;Series;sex;Sexual Dysfunction;single episode major depressive disorder;single nucleus RNA-sequencing;Structure;Suicide;Techniques;transcriptome;transcriptomics;treatment strategy;Work

PROJECT_TITLE: 1/2 Large-scale, single-cell characterization of molecular and cellular networks of mood regulation circuitry in major depressive disorder

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project narrative Medicaid is an important source of health insurance for people with substance use disorder (SUD), but many Medicaid enrollees with SUD do not receive optimal health care. Most states now contract with Managed Care Organizations (MCO) to deliver care for their SUD Medicaid population. The proposed research will provide im- portant information on how states can further improve their Medicaid program by starting, renewing or to ending contracts with MCOs.

PI_NAMEs: LINDNER, STEPHAN REINHARD (contact)

PROGRAM_OFFICER_NAME: HAEGERICH, TAMARA

PROJECT_TERMS: acamprosate;Adult;Affect;Attention;behavioral health;beneficiary;Buprenorphine;care delivery;Caring;Characteristics;Cognitive Therapy;Continuity of Patient Care;Contracts;Data;Data Files;design;Discharge Plannings;Enrollment;Event;Exclusion;health care delivery;health care service utilization;Health Insurance;Health Services;Health Services Accessibility;Healthcare;Hospitalization;Improve Access;improved;Information Systems;insight;interest;Intervention;Interview;Managed Care;Managed Care Programs;Marketing;Medicaid;Medical;medical specialties;Methods;Monitor;novel;Outcome;Outpatients;Patient Care Management;Performance;Persons;Pharmacotherapy;Play;Policies;Population;prevent;Process;programs;provider networks;psychosocial;Puerto Rico;Quality of Care;Quasi-experiment;Research;Research Design;Research Methodology;Risk;Role;Sampling;Service setting;Services;Source;Structure;substance use;Substance Use Disorder;trend;United States;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Examining the Effects of Medicaid Managed Care Organizations' Entries and Exits for Medicaid Enrollees with Substance Use Disorders

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Nutrition;Pediatric;Pediatric Cardiomyopathy;Physical Activity;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Heart failure is a global pandemic and is increasing in prevalence worldwide, and abnormalities in cardiac metabolism have been implicated in the genesis of cardiomyopathies and heart failure – no surprise given the massive energy demands of the heart. This project proposes development of a metabolic imaging method, hyperpolarized carbon-13 MRI, to measure key processes in glucose metabolism that are altered in heart disease, which cannot be measured by any existing technique. We will develop techniques for hyperpolarized carbon-13 MRI scanning and image analysis, and apply these to hypertrophic cardiomyopathy (HCM) patient studies where we expect to observe regional and global changes in glucose metabolism that correlate with clinical phenotype and are modulated by cutting-edge treatment strategies.

PI_NAMEs: ABRAHAM, MARIA ROSELLE;LARSON, PEDER ERIC ZUFALL (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acetyl Coenzyme A;Acetylcarnitine;Address;Aftercare;Bicarbonates;Biological Markers;Blood;Carbon;Carbon Dioxide;carbonate dehydratase;Cardiac;cardiac magnetic resonance imaging;Cardiac Myosins;Cardiomyopathies;Citric Acid Cycle;Clinic;clinical care;clinical phenotype;Coenzyme A;Coupled;Coupling;Cytosol;Data;Defect;Detection;Development;diabetic cardiomyopathy;Diastolic heart failure;Disease;Disease Management;disease prognosis;Electron Transport;Energy Metabolism;Exercise;exercise capacity;exercise training;Experimental Models;Fasting;fatty acid oxidation;Fatty Acids;FDA approved;Fibrosis;flexibility;Freezing;Functional disorder;Funding;Generations;Genotype;Global Change;Glucose;glucose metabolism;Glutamates;Glycolysis;Goals;Heart;Heart Diseases;Heart failure;heart imaging;heart metabolism;heart motion;Human;hypertensive heart disease;Hypertrophic Cardiomyopathy;Hypertrophy;Image;Image Analysis;image translation;imaging modality;improved;in vivo;in vivo imaging;Individual;inherited cardiomyopathy;inhibitor;Intervention;ischemic cardiomyopathy;Lactate Dehydrogenase;Left Ventricular Ejection Fraction;Left Ventricular Mass;Magnetic Resonance Imaging;Measures;Metabolic;Metabolic Diseases;metabolic imaging;metabolic phenotype;Metabolism;Methods;Mitochondria;mitochondrial dysfunction;Motion;MRI Scans;Muscle Cells;Myocardial;Myosin ATPase;National Heart, Lung, and Blood Institute;next generation;non-invasive imaging;novel;Oral;oxidation;pandemic disease;Patients;Phenotype;Physiological;Pilot Projects;pre-clinical;Prevalence;Process;Prognosis;Protocols documentation;Pyruvate;pyruvate dehydrogenase;recruit;regional difference;Resolution;Rest;Sampling;Scanning;secondary analysis;Stress Tests;sudden cardiac death;Systolic heart failure;Techniques;Testing;Translating;Translations;treatment strategy;Visualization

PROJECT_TITLE: Hyperpolarized 13C MRI of Cardiac Metabolic Remodeling in Heart Disease

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: || NARRATIVE The proposed work focusses on the release of the pro-hormone renin into the blood. This hormone is released almost exclusively by juxtaglomerular cells in the kidney. We present evidence that two new proteins may be involved: pannexin 1 and PIEZO1. We will study how they coordinate renin release in cells and animals.

PI_NAMEs: ISAKSON, BRANT E (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adenylate Cyclase;Aldosterone;Amplifiers;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;Animals;Antibodies;arteriole;Back;biological systems;Blood;Blood Pressure;blood pressure regulation;Calcium;Cardiovascular Diseases;Cell secretion;Cell Separation;Cells;Complex;cost;Coupled;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;ESR1 gene;Estradiol;Estrogens;experimental study;extracellular;Feedback;Feeds;Female;Hand;Hormones;human data;Hypertension;Image;In Vitro;in vivo;International;Intervention;Juxtaglomerular Cell;Kidney;Knockout Mice;male;Mechanics;Mediating;Molecular;mouse model;Mus;novel;Ovariectomy;Pathologic;Pathway interactions;Perfusion;pharmacologic;Phenotype;Phosphorylation;Phosphorylation Site;Physiological;Piezo 1 ion channel;Piezo ion channels;Post-Translational Protein Processing;pressure;Probability;Production;Productivity;prohormone;Property;protein protein interaction;Proteins;Recombinants;Regulation;Renin;Renin-Angiotensin-Aldosterone System;response;Role;sensor;sex;Signal Transduction;Site;Slice;Stimulus;Sum;Techniques;Testing;Work

PROJECT_TITLE: Panx1-PIEZO1 Interactions Regulate Renin Release

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Typhoidal Salmonella serovars cause an estimated 22 million cases of enteric fever each year worldwide, which remains a significant cause of infectious disease morbidity and mortality in lower-income countries. Our understanding of enteric fever pathogenesis is incomplete due to the absence of convenient animal models. In this application, we will elucidate molecular mechanisms of typhoidal Salmonella serovars survival and replication in infection-relevant conditions, including human macrophages in vitro and in humanized mice, which will provide new insights into the pathogenesis of enteric fever caused by nontyphoidal Salmonella.

PI_NAMEs: MONACK, DENISE M (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Animal Model;Anti-Inflammatory Agents;Bacteria;Bar Codes;Biochemical;Bioinformatics;Cessation of life;Communicable Diseases;comparative;Complex;Data;Disease;DNA;efflux pump;enteric pathogen;Environment;Essential Genes;Evolution;expectation;Experimental Designs;fitness;Food Poisoning;Gastroenteritis;Gene Cluster;Gene Expression Profiling;gene function;Gene Modified;Genes;Genomics;Goals;Homeostasis;Horizontal Gene Transfer;Human;humanized mouse;Immune;Immune system;In Vitro;in vivo;Infection;insight;Investigation;Knowledge;Libraries;Link;low income country;Macrophage;Manganese;Membrane;Metabolic;Metals;Methodology;Mobile Genetic Elements;Molecular;Morbidity - disease rate;mortality;Mus;mutant;non-typhoidal Salmonella;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity Island;Pathway Analysis;Pathway interactions;Phenotype;Phosphorylation;Protein translocation;Proteins;Pseudogenes;Research;Resistance;Role;Salmonella;Salmonella typhi;Salmonella typhimurium;Shapes;Site;STAT3 gene;Stress;Study models;Testing;Therapeutic;trafficking;trait;Type III Secretion System Pathway;Typhoid Fever;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Salmonella Interactions with Macrophages

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Sleep Research;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The objective of this project is to understand the mechanisms underlying brain aging and neurodegeneration in males and females. This proposal is focused on a region of the brain known as the hypothalamus, which is critical for controlling sleep, food intake, the stress response, cognition, and neuroendocrine functions. This work will provide insights into how these functions are affected in healthy aging and diseases such as Alzheimer’s disease.

PI_NAMEs: YU, DOUDOU  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Affect;Age;age related changes;age related neurodegeneration;aged;Aging;aging biomarker;aging brain;aging population;aging process;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Apolipoprotein E;Autopsy;biological adaptation to stress;Biology of Aging;Body Composition;Body Weight;Brain;Brain region;cell age;Cell Nucleus;cell type;Cells;Circadian Dysregulation;Circadian Rhythms;Cognition;Complex;Computational Biology;Country;Cues;Data;Development;Diet;Disease;Disease Progression;Disproportionately impacts women;Eating;Epigenetic Process;Equilibrium;Exhibits;extend lifespan;Female;Fibroblasts;functional decline;Gene Expression;Gene Expression Regulation;Gene Silencing;Genes;Genetic Predisposition to Disease;Genetic Transcription;genotypic sex;Goals;hallmarks of aging;Health;healthspan;healthy aging;Heterochromatin;Heterogeneity;Hormones;Human;Hypothalamic structure;Immune;Impaired cognition;In Vitro;in vivo;Individual;Induced Neurons;Inflammation;Inflammatory;insight;Intervention;Intrinsic factor;Knowledge;Laboratories;life span;Link;Machine Learning;machine learning method;machine learning model;male;Mammals;men;Metabolism;Methods;Microglia;Modeling;mouse model;Mus;Nerve Degeneration;neural;Neurons;Neurosciences;Neurosecretory Systems;normal aging;novel marker;Outcome;Phase;Phenotype;Physiological;Postdoctoral Fellow;Predisposition;preservation;Process;Publishing;Regulation;Research Project Grants;resilience;Resolution;response;sex;Sex Differences;sexual dimorphism;Sleep;sleep regulation;specific biomarkers;Stress;Testing;Tissues;tool;Training;transcriptomics;Universities;Up-Regulation;Woman;women versus men;Work;X Inactivation

PROJECT_TITLE: Selective vulnerability of cell types in brain aging and Alzheimer's disease


NIH_SPENDING_CATS: Biotechnology;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Lung;Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE  Duchenne muscular dystrophy (DMD) is a devastating genetic disease which causes progressive muscle weakness, cardiac and breathing difficulties. There is no cure for DMD, and many patients eventually die from respiratory failure. Furthermore, approximately 1/3 of patients have neurological pathology. In this proposal, we will examine the impact of DMD on the breathing muscles, nerves, and central nervous system in mouse models of DMD that have the human genetic mutation. Next, we will examine the impact of a novel adeno-associated viral (AAV) gene therapy to treat both the breathing deficits and the global pathology of DMD.

PI_NAMEs: ELMALLAH, MAI  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: 5 year old;Acceleration;Address;adeno-associated viral vector;Affinity;Animal Model;Automobile Driving;Axon;axonopathy;Behavior;boys;Brain Stem;Breathing;Capsid;Cardiac;Cause of Death;Central Nervous System;Cervical spinal cord structure;Clinic;Clinical Treatment;Clinical Trials;clinically relevant;Dependovirus;Development;Disease;DNA Sequence Alteration;Duchenne muscular dystrophy;dysmyelination;Dystrophin;efficacy evaluation;Evaluation;Exhibits;experimental study;Failure;FDA approved;Functional disorder;Future;gene therapy;Genes;Genetic Diseases;Genetic Transcription;Genotype;Grant;Histologic;Histopathology;Human;Human Genetics;humanized mouse;Hypoglossal nerve structure;Hypoventilation;Impaired cognition;Impairment;improved;innovation;interest;Limb structure;Link;Maintenance;mdx mouse;micro-dystrophin;Molecular;Morbidity - disease rate;Motor;Motor Neurons;mouse model;Mus;Muscle;Muscle function;Muscle Weakness;Muscular Dystrophies;muscular dystrophy mouse model;muscular structure;Mutation;myelination;Myocardium;Myopathy;Nerve;neuroinflammation;Neurologic Symptoms;neurological pathology;neuropathology;Neuropathy;next generation;novel;novel therapeutics;Outcome;Outcome Measure;Pathology;Pathway interactions;Patients;Physiological;preclinical study;preclinical trial;Production;Proteins;Reporting;respiratory;Respiratory Center;Respiratory Diaphragm;Respiratory Disease;Respiratory Failure;Respiratory Insufficiency;Respiratory Muscles;Respiratory physiology;Respiratory System;Series;single nucleus RNA-sequencing;Skeletal Muscle;Structure;Structure of phrenic nerve;Therapeutic;Therapeutic Studies;Translating;translational impact;United States National Institutes of Health;Viral Genes;Work;young man

PROJECT_TITLE: Optimizing Gene Therapy for Respiratory Insufficiency in Duchenne Muscular Dystrophy

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Physical Activity;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Physical inactivity is a global public health problem that is associated with numerous chronic conditions in both urban and rural populations. Older adults with cardiovascular disease who complete cardiac rehabilitation are an especially high-risk group who have a major drop off in physical activity, making them vulnerable to poor health outcomes. Our clinical trial will determine whether a virtual coaching and social support intervention promotes maintenance of physical activity after cardiac rehabilitation as well as psychosocial (e.g., depression, loneliness), social cognitive (e.g., self-efficacy), and clinical (e.g., high blood pressure/cholesterol) outcomes.

PI_NAMEs: PARK, LINDA GRACE (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Age;Aging;arm;Behavior;Behavioral;Blood Pressure;Body mass index;Cardiac;Cardiac rehabilitation;Cardiovascular Diseases;cardiovascular disorder risk;Cholesterol;Chronic;Clinical;clinical outcome assessment;Clinical Trials;Cognitive;comparison control;Control Groups;cost;Diabetes Mellitus;digital health;digital technology;Drops;Education;efficacy testing;ethnic diversity;ethnic minority;Event;evidence base;Evidence based intervention;Exercise;exercise training;Feedback;fitness;functional decline;Future;Glycosylated hemoglobin A;Goals;group intervention;Guidelines;Health;Health behavior;Health Promotion;high risk;high risk population;Home;hospital readmission;Hyperlipidemia;Hypertension;Impaired cognition;improved;Individual;Informal Social Control;innovation;interest;Intervention;intervention effect;Interview;Left;Lipids;Loneliness;Maintenance;Measurement;Measures;Mediating;Mental Depression;mental function;Minority Groups;Minority Women;mobile application;Monitor;Morbidity - disease rate;mortality;Motivation;Multimedia;Myocardial Infarction;neglect;novel;Obesity;older adult;older patient;Outcome;Patient Compliance;Patient Self-Report;Patients;Phase;Physical activity;Physical Function;physical inactivity;Pilot Projects;poor health outcome;Population;prevent;Prevention;Prevention program;Preventive;program costs;programs;psychosocial;Psychosocial Assessment and Care;Public Health;public health priorities;Qualitative Research;Quality of life;racial diversity;racial minority;Randomized, Controlled Trials;readmission rates;Recommendation;recruit;Regimen;Rehabilitation Centers;Reporting;Research;response;revascularization;Risk;Risk Factors;Rural;rural area;Rural Community;rural dwellers;Rural Population;Sampling;Secondary Prevention;sedentary;Self Efficacy;social;social cognitive theory;social engagement;Social Functioning;social interventions;Social Network;Social support;Social Values;Spanish;Spanish/English;System;Target Populations;technology intervention;Testing;Text Messaging;Time;Training;Underrepresented Populations;United States National Institutes of Health;urban area;Urban Community;Urban Population;virtual;virtual coach;virtual technology;wearable device;Weight;Woman;Work

PROJECT_TITLE: Supportive Training After Cardiac Rehabilitation Including Virtual Engagement: The STRIVE Study

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Genetics;Lymphatic Research;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inherited mutations in RASA1 cause vascular anomalies that appear at birth and can have major negative health impacts. The proposed studies will investigate the role of RASA1 during embryonic development and assess the zebrafish as a model to study associated vascular anomalies.

PI_NAMEs: LAWSON, NATHAN D (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Adult;Affect;Alleles;Anatomy;angiogenesis;Animal Model;Apoptosis;Arteries;Arteriovenous malformation;autosomal dominant mutation;Birth;Blood capillaries;Blood Vessels;Brain;burden of illness;capillary bed;Cardiac;Cardinal vein;causal variant;Cells;cognitive function;Collagen Type IV;Cre driver;Defect;deletion analysis;Development;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Ephrins;Exhibits;Failure;fetal;Genes;Genetic;genetic analysis;genetic approach;Germ Lines;Growth;Growth Factor;GTPase-Activating Proteins;Guanosine Triphosphate Phosphohydrolases;Health;Heritability;Heterozygote;hindbrain;Human;Hydrops Fetalis;in vivo;Inherited;innovation;insight;Intercellular Fluid;Knock-out;Lead;Lesion;Liquid substance;Location;LoxP-flanked allele;Lymphatic;lymphatic development;lymphatic malformations;lymphatic vessel;malformation;Mediating;Modeling;Molecular;Morphogenesis;Morphology;mosaic;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nature;Neonatal;novel;Operative Surgical Procedures;Pathway interactions;Patients;Phenotype;Phosphorylation;Pleural effusion disorder;Port-Wine Stain;postnatal;Pre-Clinical Model;Preclinical Testing;predictive modeling;Process;progenitor;Proteins;Receptor Protein-Tyrosine Kinases;response;Role;Signal Transduction;Skin;small molecule therapeutics;Specific qualifier value;stem cells;Syndrome;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Tissues;tool;Vascular Endothelial Growth Factors;Veins;vessel regression;Zebrafish

PROJECT_TITLE: Role of Rasa1 in embryonic development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDD-Q (81)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation;Social Determinants of Health

ORG_CITY: Charlestown

ORG_NAME: MGH INSTITUTE OF HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The proposed research addresses social connectedness and, consequently, the overall health and quality of life outcomes of people with neuromotor disease. Determining the factors that contribute to the social isolation and loneliness of people with amyotrophic lateral sclerosis (ALS) will promote health through the development of novel assessment and treatment approaches designed to facilitate social connectedness.

PI_NAMEs: CONNAGHAN, KATHRYN PATRICIA (contact);GREEN, JORDAN R

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Address;Affect;Age;ALS patients;Amyotrophic Lateral Sclerosis;biopsychosocial;Cellular Phone;Clinical;Cognitive;cohort;Communication;Communities;Data;Data Collection;design;Development;Disease;Disease Progression;Dysarthria;Environment;Family;Global Positioning System;Goals;Health;Health Promotion;high risk;Immobilization;Impairment;Individual;innovation;Knowledge;Link;Loneliness;Longitudinal Studies;Maps;Measures;Mediating;Medical Research;mHealth;minimally invasive;mobile computing;Mobility decline;Modeling;Moods;Motor;motor deficit;Nervous System Disorder;network models;Neurology;novel;Outcome;Ownership;Participant;Patient Self-Report;Patients;Perception;Persons;Physical therapy;Positioning Attribute;protective factors;psychosocial;Psychosocial Factor;Quality of life;remediation;Research;Research Design;response;Risk Factors;Series;service providers;Severities;Severity of illness;social;social health determinants;Social isolation;Social Network;social stigma;Speech;Speech Disorders;Speech-Language Pathology;Surveys;System;therapy design;Time;Walking

PROJECT_TITLE: Social Connectedness in People with Amyotrophic Lateral Sclerosis: The Impact of Dysarthria, Immobility, and Psychosocial Factors

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Portland

ORG_NAME: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER

PHR: PROJECT NARRATIVE Circadian rhythms powerfully regulate our daily physiological and mental functions, but these rhythms can be disrupted in shift work, during jet lag, during ageing, and in individuals with a wide variety of neurological disorders. Individuals with these conditions experience cognitive impairment. Our studies focus on neural mechanisms in the prefrontal cortex that we believe contribute to this impairment during disruption of daily rhythms. These studies have translational potential in humans because impaired cognition can be debilitating for those with altered sleep/activity rhythms and for those with disorders linked to dysregulation of biological timing mechanisms.

PI_NAMEs: IMPEY, SOREN ;SORG, BARBARA A (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Address;Adult;Aging;aging population;Amygdaloid structure;ARNTL gene;Auditory;Automobile Driving;Behavior;Binding;Biological;Biological Clocks;Brain;brain circuitry;Brain region;Cells;chromatin immunoprecipitation;circadian;circadian regulation;Circadian Rhythms;Clock protein;Cognitive deficits;Communication;conditioned fear;Coupling;Crying;Darkness;Data Storage and Retrieval;Disease;Diurnal Rhythm;Electrophysiology (science);Excision;Exhibits;experience;Extracellular Matrix;fear memory;Genes;genetic approach;genome editing;Hippocampus;Homeobox;Human;Immunochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Individual;innovation;Interneurons;Jet Lag Syndrome;Learning;Light;Link;Location;Measures;Medial;Memory;memory retrieval;mental function;Molecular;N-Methylaspartate;Nervous System Disorder;neuromechanism;Neuronal Plasticity;Neurons;novel;object recognition;Organism;Output;Parvalbumins;Pattern;Periodicity;Phase;Physiological;Play;Prefrontal Cortex;prevent;promoter;Property;Prosencephalon;Proteins;Rattus;Regulation;Retrieval;Role;shift work;Signaling Protein;Sleep;Structure;Synapses;Testing;Time;translational potential;Work

PROJECT_TITLE: Regulation of diurnal rhythms in parvalbumin and perineuronal net function

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Regenerative Medicine;Stroke

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Brain ventricle is lined by specialized cells known as ependyma, which bears dozens of motile cilia. Ciliary beating contributes to the flow of cerebrospinal fluid. In the proposed study, we will determine whether occurrence of intraventricular hemorrhage (IVH) disrupts the development of ependyma and motile cilia and if so, how this can reversed to restore CSF flow and prevent hydrocephalus in the premature newborns with IVH. This research is relevant to public health because discovery of mechanisms by which IVH contributes to hydrocephalus will lead to interventions to prevent this disorder.

PI_NAMEs: BALLABH, PRAVEEN  (contact)

PROJECT_TERMS: Affect;Agonist;Animal Experiments;Apoptosis;Astrocytes;ATP1A1 gene;Attenuated;Autopsy;Behavior;Behavioral;Brain;Cell Physiology;Cell Proliferation;Cells;Cellular Structures;Cerebral aqueduct;Cerebral Palsy;Cerebral Ventricles;cerebrospinal fluid clearance;cerebrospinal fluid flow;Cilia;cilium biogenesis;cilium motility;Cleavage Under Targets and Release Using Nuclease;Cognitive deficits;Complication;Cyclic AMP;Data;density;Development;Disease;Electron Microscopy;Ependyma;Ependymal Cell;Exhibits;Fetus;Gene Mutation;Gene Targeting;Genes;Gestational Age;Head;Hemorrhage;Histology;Human;Hydrocephalus;Immunohistochemistry;Infant;Inflammation;Injury;Intervention;intraventricular hemorrhage;Knockout Mice;Measures;Mediating;Modeling;Movement;mutant;Mutation;nerve stem cell;neurobehavioral;Neuroglia;Neurologic;neurological recovery;novel therapeutics;optimal treatments;Oryctolagus cuniculus;overexpression;Population;postnatal;premature;Premature Infant;preterm newborn;prevent;Production;programs;Proliferating;Pseudostratified Epithelium;Public Health;purmorphamine;Radial;repaired;Research;restoration;Role;Sampling;Scanning Electron Microscopy;SHH gene;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;smoothened signaling pathway;Specific qualifier value;stem cell proliferation;stem cells;Structure of choroid plexus;subventricular zone;Survivors;Testing;therapy development;Time;transcription factor;transcriptomics;Transmission Electron Microscopy;ultrasound;Up-Regulation;Ventricular

PROJECT_TITLE: Restoration of ependymal integrity reduces posthemorrhagic hydrocephalus in preterm neonates

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Orphan Drug;Pediatric;Primary Immunodeficiencies;Rare Diseases;Schizophrenia;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative Both mitochondrial and blood brain barrier (BBB) dysfunction have been independently associated with neuropsychiatric illness. Based on our recent publications and compelling preliminary data, we propose that in a relatively common genetic cause of neuropsychiatric illness, mitochondrial dysfunction contributes to BBB dysfunction and presents a novel therapeutic target. If our hypothesis is correct, this finding can shift paradigms for inflammatory influences on brain development and function based on the synergistic influences of relatively subtle structural and energetic weaknesses in the BBB.

PI_NAMEs: ALVAREZ, JORGE IVAN (contact);ANDERSON, STEWART A

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 22q11.2;3' Untranslated Regions;Agonist;Animals;Area;autism spectrum disorder;Behavioral;behavioral phenotyping;Bezafibrate;Biogenesis;Birth;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Cells;blood-brain barrier function;Brain;brain health;Cell Line;cell type;Cells;clinically relevant;Cognitive deficits;Complex;Data;Defect;Development;diet and exercise;DiGeorge Syndrome;Disease;Endothelium;experimental study;FDA approved;functional restoration;Gene Deletion;Genes;Genetic;Heterozygote;Hippocampus;Immune;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammatory;Intellectual functioning disability;Intervention;knock-down;Knockout Mice;lymphoblastoid cell line;Measures;Memory impairment;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mouse model;Mus;Mutation;Neurodevelopmental Disorder;neuroinflammation;neuropsychiatric disorder;neuropsychiatry;neurovascular;new therapeutic target;Nicotinamide Mononucleotide;novel therapeutics;Oxidative Phosphorylation;Peripheral;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;pharmacologic;Phenotype;Process;Production;Property;Proteins;Publications;Publishing;Risk;Schizophrenia;schizophrenia risk;social;System;Testing;Therapeutic;Therapeutically Targetable;Tight Junctions;Variant;Work

PROJECT_TITLE: Mitochondrial influences on blood brain barrier function and neuropsychiatric illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-M(91)]


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: NASHVILLE

ORG_NAME: VOLUMETRIX, LLC

ORG_STATE: TN

PHR: Project Narrative Decompensated HF is the leading cause of hospitalization. HF leads to water accumulation in the tissues (lungs and legs) resulting in shortness of breath and leg swelling. This project will advance the development of an accurate, inexpensive, easy to use device (“NIVAHF”) for volume measurements in patients with HF. Use of these devices will ultimately help health care providers and patients prevent water overload. The long-term goal is to prevent costly hospital readmissions, improve quality of life, and reduce mortality in patients with HF.

PI_NAMEs: HOCKING, KYLE MITCHELL (contact);LINDENFELD, JOANN

PROGRAM_OFFICER_NAME: TINSLEY, EMILY

PROJECT_TERMS: Advanced Development;Algorithm Design;Blood capillaries;Clinical;commercialization;Congestive Heart Failure;Data;Device Designs;Devices;diagnostic tool;Elderly;Experimental Animal Model;Goals;Health Personnel;Heart failure;Hospital Costs;hospital readmission;Hospitalization;Human;improved;Laboratories;Leg;Lung;Measurement;Monitor;mortality;Patients;Phase;Physiological;prevent;Process;Quality of life;Shortness of Breath;Signal Transduction;Signs and Symptoms;Swelling;Tissues;usability;Venous;Water;Work

PROJECT_TITLE: Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)


NIH_SPENDING_CATS: Aging;Amyotrophic Lateral Sclerosis (ALS);Bioengineering;Brain Disorders;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Project Narrative This project seeks to develop a Bayesian computational system to model longitudinal functional microcircuits and use it to examine microcircuit changes in TDP-43 knockout mouse model. We will have delineated a unique brain network mechanism in TDP-43 related neurodegeneration, leading to novel therapeutic concepts.

PI_NAMEs: CHEN, RONG  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Address;Algorithms;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animals;awake;Bayesian Analysis;Bayesian learning;Bayesian Method;Bayesian Modeling;Brain;Calcium;Cells;Code;Complex;computational neuroscience;Data;Data Analyses;data modeling;Data Set;density;design;Development;Disease Progression;Encephalopathies;Enterobacteria phage P1 Cre recombinase;Exhibits;Exons;experience;feature extraction;Foundations;Frontotemporal Dementia;Genes;Heart;high dimensionality;hippocampal pyramidal neuron;Image;information processing;innovation;interest;Knock-out;Knockout Mice;Learning;longitudinal analysis;longitudinal dataset;loss of function;Machine Learning;machine learning method;Measures;Methods;Modeling;mouse model;multidimensional data;Mus;Nerve Degeneration;neural;Neurodegenerative Disorders;neuroimaging;Neurons;novel;novel therapeutics;Nuclear;Nuclear RNA;optical imaging;Outcome;Participant;Pathogenesis;Pathologic;Pathway interactions;Pattern;Positioning Attribute;Prefrontal Cortex;premature;Prevalence;Process;protein TDP-43;Records;Reporting;Research Personnel;Resolution;RNA Splicing;RNA-Binding Proteins;Sampling;Site;Solid;System;temporal measurement;Terminator Codon;Therapeutic;Time;tool;Transcriptional Regulation;Work

PROJECT_TITLE: Understanding dynamics of brain network in TDP-43 related neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (80)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PI_NAMEs: VU, BAO GIA (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Biology;Candida;Candida glabrata;drug development;Drug resistance;Environment;Genes;Genetic Techniques;Genetic Transcription;Goals;Growth;human pathogen;Hypoxia;Immunity;Infection;interdisciplinary approach;Knowledge;Metabolism;microbial;Molecular Genetics;next generation sequencing;novel;Oklahoma;Organism;Pathogenesis;Physiology;Proteins;Proteomics;resistance mechanism;respiratory;response;Role;transcription factor;transcriptomics;Translating;Work

PROJECT_TITLE: Transcriptomic and proteomic analyses of Upc2A under Candida glabrata hypoxic growth


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Alcohol dependence and alcohol use disorder (AUD), as well as stress-related disorders such as post-traumatic stress disorder (PTSD) constitute a significant health concern for our Veterans. Given that the prevalence of AUD and PTSD comorbidity is especially high in Veterans, the need to better understand how stress interacts with alcohol is critical for developing more effective treatments for this significant health problem. This research project utilizes a model in which stress further enhances escalated alcohol drinking associated with dependence. The main objective of the project is to examine brain mechanisms underlying the ability of exercise to attenuate stress-enhanced drinking in dependent subjects. The ultimate goal is to provide new insights about mechanisms underlying a promising therapeutic intervention that will aid in treatment for individuals suffering from alcohol dependence and the exacerbating effects of stress that lead to harmful drinking - an especially important and clinically relevant problem for our Veteran patients.

PI_NAMEs: BECKER, HOWARD C. (contact)

PROJECT_TERMS: Address;Affect;Agonist;Alcohol abuse;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol intervention;alcohol measurement;alcohol relapse;alcohol use disorder;Alcoholism;Alcohols;Animal Model;antagonist;Attenuated;Behavioral;Brain;Brain-Derived Neurotrophic Factor;Chronic;Clinical;clinically relevant;comorbidity;Complex;Data;Dependence;drinking;effective therapy;Ethanol;Ethanol dependence;Exercise;Exposure to;Flavones;Funding;Goals;Health;Healthcare;healthcare burden;Heavy Drinking;High Prevalence;Individual;Infusion procedures;Injections;insight;Intake;Intervention;knock-down;Mediating;Modeling;mouse model;Mus;neuroadaptation;neuromechanism;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel;novel therapeutic intervention;overexpression;Patients;Phosphorylation;Pilot Projects;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Prevalence;prevent;programs;receptor;Receptor Signaling;Recurrent disease;Relapse;Research;Research Project Grants;Research Proposals;Role;Running;Signal Transduction;Signaling Molecule;Small Interfering RNA;Societies;Stress;stress related disorder;Swimming;Therapeutic Intervention;treatment strategy;Veterans;Viral;Work

PROJECT_TITLE: Role of BDNF in Stress Effects on Ethanol Dependence-Induced Escalated Drinking


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Project Narrative Cardiovascular disease and metabolic syndromes are the rising health risk factor to our returning Gulf War and Afghanistan Veterans. Exercise-mediated hemodynamic forces impart both metabolic and mechanical effects to initiate atherosclerosis. While elucidating vascular metabolomic profiles in reponse to pulstile vs. disturbed flow uncovers metabolic biomarkers and therapeutic targets, developing 3-D electrochemical impedance sensors provides new insights into detecting arterial metabolic changes in response to hemodynamic forces.

PI_NAMEs: HSIAI, TZUNG K (contact)

PROJECT_TERMS: 3-Dimensional;6-Phosphofructo-2-kinase;Afghanistan;Agonist;Angiography;Arterial Fatty Streak;atheroprotective;Atherosclerosis;Attenuated;Autophagosome;Biological Markers;Biology;Blood Vessels;Cardiovascular Diseases;Detection;Development;Diameter;dielectric property;DNA Damage;Dominant-Negative Mutation;electric impedance;electrical property;Electrodes;Endothelium;Exercise;exercise intervention;Fatty Acids;flexibility;Frequencies;Fructose;Genetic Models;Glycolysis;Gulf War;Health;heart disease risk;hemodynamics;Homeostasis;Hyperlipidemia;Impairment;insight;Lesion;Life Style Modification;lipid metabolism;Lipids;MAPK8 gene;Maps;Mechanics;Mediating;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolic syndrome;metabolomics;meter;Microelectrodes;Middle East;Mitochondria;Mitochondrial DNA;Modeling;monocyte;Mus;N-terminal;NADPH Oxidase;Natural regeneration;Nature;New Zealand;Nuclear Hormone Receptors;Oryctolagus cuniculus;oxidized low density lipoprotein;Pathway interactions;Peroxisome Proliferator-Activated Receptors;Phase;Phosphotransferases;Production;protein aggregation;Pulsatile Flow;receptor;recruit;repaired;response;Risk Factors;rosiglitazone;sensor;shear stress;Signal Pathway;Signal Transduction;Spectrum Analysis;Stress;Testing;Therapeutic;therapeutic target;Tissues;Vascular Endothelial Cell;Vascular regeneration;Veterans;Wild Type Mouse

PROJECT_TITLE: Exercise-Induced Shear Stress Modulates Metabolic Pathways for Vascular Repair and Protection

STUDY_SECTION: CARB

STUDY_SECTION_NAME: Cardiovascular Studies B[CARB]


ORG_CITY: HUNTINGTON

ORG_NAME: HUNTINGTON VETERANS AFFAIRS MED CTR

ORG_STATE: WV

PHR: Pre-deployment hazardous binge drinking is highly prevalent in active-duty US military personnel and can increase the likelihood of developing an alcohol use disorder. This is particularly relevant to combat veterans who increasingly treat symptoms of depression and anxiety by ‘self-medicating’ with alcohol. This research furthers the VA mission by identifying novel non-neuronal mechanisms that are involved in the dysregulation of neuronal activity and subsequent neuronal remodeling that occurs after binge ethanol exposure. Understanding these mechanisms in the context of synaptic dysfunction and the emergence of alcohol use disorder could lead to the development of novel pharmacotherapies designed to break the cycle of chronic substance abuse in this at-risk population.

PI_NAMEs: RISHER, MARY-LOUISE  (contact)

PROJECT_TERMS: active duty;Acute;Affect;Afghanistan;Age;aged;Alcohol abuse;alcohol abuse therapy;alcohol exposure;alcohol misuse;alcohol use disorder;Alcohols;anxiety symptoms;Astrocytes;Automobile Driving;Behavior;Behavioral;binge drinking;Cells;Central Nervous System;Chronic;Cognitive deficits;combat veteran;Communication;Consumption;Coupling;Data;Dendritic Spines;depressive symptoms;design;Development;drinking;drinking behavior;Drug Exposure;Electron Microscopy;Electrophysiology (science);Ethanol;Female;Freedom;Fright;Functional disorder;Goals;hazardous drinking;Health;Hippocampus;Homeostasis;Hyperactivity;Immunohistochemistry;Impaired cognition;Impairment;In Vitro;in vivo;Induced Neurons;innovation;insight;Ions;Knowledge;Label;Learning;Link;Long-Term Effects;male;Mediating;Mediator;member;Memory impairment;Military Personnel;military veteran;Mission;Modeling;Molecular;Morphology;neuronal circuitry;Neurons;novel;operation;Output;peer;Pharmacotherapy;Population;Populations at Risk;Positioning Attribute;Prevalence;prevent;Prevention;Process;Rattus;Regulation;Reporting;Research;Research Personnel;resilience;Risk;Risk Factors;Role;Short-Term Memory;Signal Transduction;Site;Slice;spatiotemporal;Structure;Substance abuse problem;Surveys;symptom treatment;Synapses;synaptic function;Synaptic Transmission;targeted treatment;Vertebral column;Veterans;Viral;Vulnerable Populations

PROJECT_TITLE: Long-term effects of binge drinking on astrocyte-synaptic interactions


FUNDING_MECHANISM: OTHERS

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Photoreceptor dysfunction is one of the hallmark pathologies associated with retinal degenerative (RD) diseases that manifests in patients as a progressive loss of vision. This encompasses heterogenous diseases such as retinitis pigmentosa, which affects 1 in 3500 people worldwide and age-related macular degeneration, which is projected to affect 288 million people by 2040. We have shown modest exercise provides retinal neuroprotection in a mouse model of RD, through increased brain derived neurotrophic factor (BDNF) signaling. The cellular modifications provoking neural protection and repair from exercise are not understood. Our proposal reveals novel data supporting retinal astrocyte and vasculature involvement in exercise-induced BDNF signaling. Our studies will illuminate the roles of retinal astrocytes and vasculature in this known neuroprotective therapy, ultimately optimizing exercise-based therapeutics and creating new pharmacological strategies targeting the underlying mechanisms of exercise-induced neuroprotection.

PI_NAMEs: BALES, KATIE LEIGH (contact)

PROJECT_TERMS: Affect;Affinity;Age related macular degeneration;Animal Model;antagonist;Astrocytes;Atrophic;Award;Biological Assay;Biology;Blindness;Blood Vessels;Brain;Brain-Derived Neurotrophic Factor;Cell Density;Cell Separation;cell type;Cells;Cellular Morphology;Clinical Research;Clinical Trials;Computer software;Data;density;Disease;Disease Progression;Endothelial Cells;Exercise;exercise intervention;Exhibits;experimental group;Foundations;Functional disorder;functional improvement;Future;gain of function;Gene Expression;Gene Expression Profile;gene function;Goals;Healthcare;Hyperemia;Image;improved;In Vitro;Inbred BALB C Mice;Inflammation;Intervention;Knowledge;Label;Light;Light Exercise;Magnetism;Mediating;military veteran;Modeling;Modification;Molecular;Monitor;Morphology;mouse model;Mus;Nerve Degeneration;neural;neural repair;Neurodegenerative Disorders;neuroinflammation;Neuronal Plasticity;neuroprotection;Neurotrophic Tyrosine Kinase Receptor Type 2;neurovascular coupling;novel;Outcome Study;Pathogenesis;Pathology;patient population;Patients;Persons;Phagocytosis;pharmacologic;Phenotype;Photoreceptors;Physiological;preservation;Process;receptor;repaired;Research;response;Retina;Retinal Degeneration;Retinitis Pigmentosa;Retrospective Studies;Role;Severities;Severity of illness;Signal Transduction;Stress;Structure;Testing;Therapeutic;Translating;Up-Regulation;Vascular Endothelial Cell;Veterans;Vision;Visual impairment;Writing

PROJECT_TITLE: Investigating the role of retinal astrocytes in exercise-induced retinal neuroprotection


ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Obesity affects more veterans than the general population and even more so among veterans using VA health care services. Moreover, the number of obese older veterans has markedly increased because of both the increase in the aging of the veteran population and the percentage of older veterans who are obese. In older veterans, obesity aggravates the age-related decline in physical function resulting in frailty that leads to loss of independence in activities of daily living. However, lifestyle therapy resulting in weight loss in obese older adults remains controversial because of concerns about harmful effects of weight loss on muscle and bone mass in this population. Metformin, a drug widely used to treat diabetes, could slow the aging process and improve health span, the part of a person’s life during which they are in good health. It is possible that the addition of metformin to lifestyle therapy will reverse frailty and preserve muscle and bone mass in obese older veterans, thereby prevent their loss of independence and decrease need for admission to a VA nursing home care.

PI_NAMEs: VILLAREAL, DENNIS T. (contact)

PROJECT_TERMS: Activities of Daily Living;Admission activity;adult obesity;Affect;age acceleration;age related;age related decline;Aging;aging process;Anabolism;Animals;Biguanides;Blood;Body mass index;Body Weight decreased;bone;Bone Density;bone mass;bone quality;Cell Aging;Cell Cycle Arrest;Chronic;Clinical;comparative efficacy;Data;Diabetes Mellitus;Diet;Drug usage;Dual-Energy X-Ray Absorptiometry;Elderly;Exercise;exercise training;extend lifespan;Failure;Finite Element Analysis;Frail Elderly;frailty;functional independence;functional loss;functional outcomes;functional status;Future;Gait speed;General Population;Goals;Head;head-to-head comparison;Health;health care service;Health Personnel;Healthcare Systems;healthspan;high risk population;Home Nursing Care;Human;human old age (65+);Immunohistochemistry;Impairment;improved;Intervention;lean body mass;Length;Life;life span;lifestyle intervention;Lifestyle Therapy;Magnetic Resonance Imaging;Mediating;Medical;Metformin;military veteran;mortality;multi-component intervention;Muscle;muscle form;muscle strength;Muscular Atrophy;Non-Insulin-Dependent Diabetes Mellitus;novel;Nursing Homes;obese patients;Obesity;Obesity Epidemic;Observational Study;older adult;older patient;Older Population;Oral;Osteopenia;Outcome;Overweight;Performance;performance tests;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Physical Function;Physical Performance;Placebo Control;Population;preservation;Prevalence;prevent;programs;Quality of life;Randomized, Controlled Trials;Recommendation;reduced muscle mass;Reporting;Resolution;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;sarcopenia;sarcopenic obesity;secondary analysis;senescence;senescence associated secretory phenotype;senescent cell;Skeletal Muscle;standard care;standard of care;telomere;Testing;Thigh structure;treatment group;Uncertainty;Veterans;Veterans Health Administration;Weight Gain;Weight maintenance regimen;Western Blotting;X-Ray Computed Tomography

PROJECT_TITLE: Lifestyle Intervention plus Metformin to Treat Frailty in Older Veterans with Obesity


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: BASIC HEALTH INTERNATIONAL, INC.

PHR: PROJECT NARRATIVE Existing thermal ablation probes will be optimized to improve cure rates of a handheld device commonly used in low- and middle-income countries (LMIC). This thermal ablation device will be combined with a digital colposcope to provide triage and treatment in one instrument. In addition, a machine learning algorithm will be integrated into the new device to triage women at highest risk for cervical precancer.

PI_NAMEs: ALFARO, KARLA ;MASCH, RACHEL  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Ablation;Aftercare;Algorithms;Area;automated visual evaluation;Biopsy;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cervix Uteri;Classification;Clinic;Clinical;Cold Therapy;Colposcopes;Colposcopic Biopsy;Colposcopy;common treatment;Complex;cost;Dangerousness;Data;detector;Devices;Diagnosis;Diagnostic;digital;digital imaging;Disease;Electricity;Eligibility Determination;Enrollment;Ensure;Equipment;Excision;follow-up;Gases;Genotype;handheld equipment;Health;High Risk Woman;Histopathology;HPV positive;HPV-High Risk;Human Papillomavirus;Image;improved;industry partner;Infection;innovation;instrument;International;laboratory equipment;low and middle-income countries;Machine Learning;machine learning algorithm;Malignant neoplasm of cervix uteri;manufacture;Medical;Modification;mortality;overtreatment;Pathologist;Pathology;Patients;Penetration;point of care;portability;premalignant;primary endpoint;programs;prototype;Provider;Reporting;Resources;Risk;risk stratification;ROC Curve;Scotland;screening program;Services;System;Temperature;Testing;Thermal Ablation Therapy;Time;Training;treatment optimization;treatment strategy;Triage;United Kingdom;Validation;Variant;Woman;women's treatment;World Health Organization

PROJECT_TITLE: POINT of CARE: PrOviding an Innovative New Triage and Treatment strategy for Cervical cAncer scReening Efficiency

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases

ORG_CITY: RICHMOND

ORG_DEPT: DENTISTRY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: PROJECT NARRATIVE Macrophage polarization enables macrophages adapt to different microenvironmental cues and acquire a spectrum of functional phenotypes, mainly including the classically activated (Pro-inflammatory, M1) and the alternatively (pro-healing, M2) activated phenotypes, of which the balance of M1/M2 is critical to the progression and severity of inflammatory responses and tissue damages. Thus, identification of the intracellular immune regulators that control macrophage polarization in periodontitis is key to redirect the dysregulated macrophage phenotypes and develop the novel host-directed therapeutics for this disease. We have identified the alternative macrophage polarization mediated by an oral model organism, porphyromonas gingivalis (Pg), that flows via SGK1-YAP1 signaling, a novel and potent regulatory module in periodontal inflammation, which will not only advance our understanding of the host immune response to Pg but also inform studies to identify novel targets to restore the balance of different macrophages subsets and thus ameliorate or prevent Pg-induced tissue destruction.

PI_NAMEs: WANG, HUIZHI  (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adopted;Alveolar Bone Loss;Biological Assay;Biological Response Modifiers;bone loss;Categories;Cells;Classification;Clinical Trials;Cues;cytokine;Cytoplasm;Data;Disease;Disease Progression;Environment;Equilibrium;Event;gain of function;Gingiva;Glucocorticoids;Goals;healing;Immune;Immune response;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;knockout gene;Knockout Mice;Lead;Left;loss of function;Macrophage;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;model organism;Modeling;Molecular;Mus;Neutrophil Infiltration;novel;Nuclear;Oral;Oral cavity;oral pathogen;Patients;Pattern;Periodontitis;Periodontium;Phagocytes;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Play;Porphyromonas gingivalis;prevent;Process;Production;Proteasome Inhibitor;Proteins;Regulation;Research;response;Role;Serum;Severities;side effect;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Testing;Therapeutic;Time;Tissues;Transcription Coactivator;transcription factor;Transcriptional Coactivator with PDZ-Binding Motif;Ubiquitin;Ubiquitination;Work

PROJECT_TITLE: SGK1 and the control of periodontal inflammation

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Narrative The mechanisms by which global regulatory proteins operate on their RNA targets are complex and are still largely not understood; understanding these mechanisms is crucial for preventing or alleviating bacterial infections and antibiotic resistance. The overarching goal of the proposed work is to characterize in vivo the molecular features that underlie novel CsrA-target interactions that we have recently uncovered as well as to decipher the biological relevance of these interactions; the CsrA protein is part of the Csr (carbon storage regulator) system, a global regulatory network known to impact virulence factors, secretion systems, and other important genes for rapid host adaptation in a number of pathogens. We expect these studies to further expand our knowledge of the diversity of post-transcriptional regulation approaches that global regulators can exert in bacteria.

PI_NAMEs: CONTRERAS, LYDIA MARIA (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 5' Untranslated Regions;Antibiotic Resistance;Bacteria;Bacterial Infections;Binding;Binding Sites;Biological;Biological Assay;Carbon;Cells;cofactor;Collaborations;Complex;EMSA;Escherichia coli;flexibility;Genes;genetic regulatory protein;Goals;head involution defective protein;Homologous Gene;In Vitro;in vivo;innovation;Knowledge;Lead;Literature;Maps;Messenger RNA;Methods;Modeling;Molecular;novel;Outcome;pathogen;Pathway interactions;Pattern;Post-Transcriptional Regulation;posttranscriptional;prevent;Proteins;Pseudomonas aeruginosa;Regulation;Reporting;Repression;Resistance to infection;RNA;RNA Binding;RNA-Binding Proteins;Scheme;Stress;System;Testing;Text;therapeutic target;time use;tool;Virulence Factors;Work

PROJECT_TITLE: Novel mechanisms of posttranscriptional regulation by CsrA

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PI_NAMEs: MILLER, CLINT L (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Affect;Angiography;Architecture;Arteries;Atherosclerosis;Automobile Driving;biobank;Biological Assay;Blood Pressure;Blood Vessels;Candidate Disease Gene;cardiometabolism;causal variant;Cell Lineage;Cell Nucleus;cell type;Cell Wall;Cells;Chromatin;Chromosome Mapping;Clinical;clinical imaging;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary artery calcification;Coronary Vessels;Coupled;Data;differential expression;Disease;Disease Outcome;disease phenotype;Disease Progression;disorder prevention;disorder risk;Endothelial Cells;Enhancers;epigenomic profiling;epigenomics;Etiology;experience;Fibroblasts;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic;Genetic Markers;genetic profiling;Genetic Variation;genome wide association study;genome-wide analysis;genomic locus;genomic profiling;Genomics;Grain;Haplotypes;Heterogeneity;Histologic;histone modification;Human;Image;Individual;Injury;insight;Knowledge;Life Style Modification;Link;Lipids;Maps;Meta-Analysis;Molecular;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;multimodality;multiple omics;Myeloid Cells;Myocardial Infarction;next generation;osteogenic;Paracrine Communication;Pathway Analysis;Pathway interactions;Patients;Phenotype;phenotypic biomarker;Population Genetics;Population Heterogeneity;Positioning Attribute;Process;Public Health;Quantitative Trait Loci;Regulation;Regulatory Element;Resolution;Resources;response;Risk Factors;risk stratification;risk variant;RNA;single cell genomics;single-cell RNA sequencing;Smooth Muscle Myocytes;Stroke;targeted treatment;Testing;tissue resource;Tissues;trait;transcription factor;transcriptomics;Translating;treatment strategy;Untranslated RNA;Vascular remodeling;Work

PROJECT_TITLE: Multimodal genetic regulatory architecture of coronary artery disease

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

PHR: Project Narrative The obligate intracellular parasites from the genus Plasmodium grow within human red blood cells, causing a lethal disease called malaria. The proposed research aims to understand the parasite-specific glycosylation pathways required for transporting proteins to specific sub-cellular locations within the infected red blood cell. The proposed study will help us identify targets for novel targets for antimalarial therapies, which are sorely needed because Plasmodium has developed resistance to all currently available antimalarial drugs.

PI_NAMEs: MURALIDHARAN, VASANT  (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Anti-malarials;asexual;Asparagine;Automobile Driving;Binding;Biological;Biological Assay;Biological Process;Blood;Carrier Proteins;Catalytic Domain;Cellular Assay;Clinical;clinically relevant;Complement;Complex;Data;Disease;Endoplasmic Reticulum;Ensure;Enzymes;Erythrocytes;Eukaryota;Event;Genes;Genetic;Glycobiology;glycoproteomics;glycosylation;glycosyltransferase;Golgi Apparatus;Growth;Homologous Gene;Human;Hydrolase;IGF Type 2 Receptor;Immune response;Immune system;in vitro Assay;Invaded;knock-down;Knowledge;Lectin;Length;Life;Life Cycle Stages;Link;Location;Lysosomes;Malaria;mannose 6 phosphate;Membrane;Modification;Molecular;Molecular Chaperones;Mutation Analysis;novel;obligate intracellular parasite;Oligosaccharides;Organelles;Organism;Parasites;Parasitology;Pathway interactions;Peptide Hydrolases;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium genome;Plastids;Polysaccharides;Post-Translational Protein Processing;programs;protein biomarkers;Protein Biosynthesis;protein folding;protein function;Protein Glycosylation;Protein Secretion;Protein Sortings;protein transport;Proteins;Proteomics;Quality Control;Reagent;Recombinants;Research;Resistance development;rhoptry;Role;Route;Serine;Sorting;Structure;Subtilisins;sugar;Symptoms;Testing;Threonine;tool;trafficking;Transferase;Vacuole;Vesicle

PROJECT_TITLE: Protein glycosylation and trafficking in Plasmodium falciparum

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Spiny mice naturally regenerate complex musculoskeletal tissues whereas other mammals use scar tissue to repair identical injuries. Thus, the proposed research is relevant to public health because discovering the cell types and molecules that permit and direct this unique example of mammalian regeneration is expected to generate novel clinical interventions to reduce fibrosis and enhance healing in humans. Stimulating tissue regeneration greatly improves the functionality of injured tissue and will help reduce the burden human disability.

PI_NAMEs: SEIFERT, ASHLEY WINN (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Acomys;Adult;Behavior;Biological Assay;Cell Aging;Cell Cycle Progression;Cell Proliferation;cell type;Cells;Chromatin;Cicatrix;Clinical;comparative;Complement;Complex;cytokine;Data;Dichloromethylene Diphosphonate;disability;Drug or chemical Tissue Distribution;Ear;Epigenetic Process;external ear auricle;Extracellular Matrix;Fibrosis;Gene Expression;Generations;Genetic;Genetic Transcription;Goals;healing;Human;improved;Infiltration;Inflammation;Inflammatory;injured;Injury;innovation;insight;Intervention;Laboratory mice;Lactoferrin;Leucocytic infiltrate;Liposomes;Macrophage;Mammals;Molecular;multiple omics;Mus;Musculoskeletal;musculoskeletal injury;Natural regeneration;novel;novel therapeutics;Oxidative Stress;Phase;Phenotype;Production;programs;Proliferating;Public Health;Publishing;re-epithelialization;regenerative;regenerative healing;regenerative tissue;repaired;Research;Resolution;response;response to injury;Rodent;Rodent Model;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Spatial Distribution;Sterility;Stress;Stromal Cells;Testing;Tissue atlas;tissue regeneration;tissue trauma;Tissues;transcriptome sequencing;VEGFC gene;Work;wound;wound healing

PROJECT_TITLE: Deciphering how tissue resident macrophages regulate musculoskeletal regeneration in spiny mice

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Autism;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative Modern genomic sequencing technologies have allowed the field to identify many risk genes associated with neurodevelopmental disorders such as autism spectrum disorder (ASD). Here we propose to further investigate the effects of CHD8, a prominent ASD risk gene that we showed affects a major neuronal population of the brain, cortical GABAergic interneurons. We will use newly-developed “brain organoid” systems, cell culture models of human brain development derived from pluripotent stem cells, to understand the effect of this ASD risk gene on interneuron development and circuit function in the human cerebral cortex.

PI_NAMEs: ARLOTTA, PAOLA  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;ASD patient;autism spectrum disorder;Binding Proteins;Biology;Brain;Brain region;Calcium;Cell Culture Techniques;cell type;Cells;Cerebral cortex;Chromatin Remodeling Factor;Collaborations;Data;Defect;Development;disorder subtype;DNA Sequence Alteration;Dorsal;Electrophysiology (science);Engineering;Equilibrium;excitatory neuron;experimental study;extracellular;Genes;Genetic;Genomics;Grant;helicase;Heterozygote;High Prevalence;Human;Human Biology;human model;Image;individual variation;inhibitory neuron;inter-individual variation;Interneurons;Lateral;Link;loss of function;Loss of Heterozygosity;Macrocephaly;Manuscripts;Medial;model of autism spectrum disorder;Modeling;Modernization;Molecular;multi-electrode arrays;Mus;mutant;Mutate;Mutation;Nature;neural;Neurodevelopmental Disorder;neurogenesis;neuron development;neuronal circuitry;Neurons;next generation;Organoids;permissiveness;pharmacologic;Pharmacology;Phenotype;Physiological;Physiology;Pluripotent Stem Cells;Population;Population Analysis;Predisposition;Preparation;Printing;progenitor;Prosencephalon;Reproducibility;Research Personnel;risk variant;Role;Synapses;System;Technology;Telencephalon;Testing;Work

PROJECT_TITLE: Modeling ASD-linked genetic mutations in 3D human brain organoids

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Mechanisms that amplify the generation of intermediate progenitors boosts stem cell output in producing differentiated cells without increasing the frequency of stem cell division thereby safeguarding the long-term health of stem cells. However, not all stem cells display this amplification mechanism in the physiological context, and it is unclear how this capacity can be activated to increase the production of differentiated cells on demand. Our proposal will investigate the mechanisms that control the amplification of intermediate progenitors and how stem cell-specific functions can be properly regulated in general to ensure normal brain development and to prevent brain tumor formation.

PI_NAMEs: LEE, CHENG-YU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;analog;Binding;Brain;Brain Neoplasms;Cell Count;Cell Differentiation process;Cell division;cell type;Cells;Childhood Brain Neoplasm;Chromatin;Collection;Competence;Data;Development;Drosophila genus;Enhancers;Ensure;experimental study;Family;fly;Frequencies;gain of function;Ganglia;Gene Activation;Gene Expression;gene regulatory network;Generations;Genes;Genetic Transcription;Health;Heterogeneity;histone modification;Histones;Image;insight;Intellectual functioning disability;Link;loss of function;Modeling;Molecular;Mothers;nerve stem cell;neuroblast;neurogenesis;Neuroglia;Neurons;notch protein;Nuclear Hormone Receptors;Outcome;Output;Pattern;Physiological;Play;premature;prevent;Production;progenitor;programs;Proliferating;Radial;Regulation;Role;Signal Transduction;single-cell RNA sequencing;Sorting;Specific qualifier value;stem cell division;stem cell function;stem cells;transcription factor;Undifferentiated;Vertebrates

PROJECT_TITLE: Regulation of generation and functions of intermediate progenitors

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]