ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: NARRATIVE The UCSF-Stanford Center of Excellence in Regulatory Sciences and Innovation (CERSI) conducts collaborative research in innovative regulatory science. This research enhances the FDA’s public health mission including the evaluation of safe and effective medical products. In addition, the CERSI develops training and outreach programs for the purpose of training students, postdoctoral fellows and career scientists in regulatory sciences.

PI_NAMEs: ALTMAN, RUSS BIAGIO;GIACOMINI, KATHLEEN M (contact)

PROGRAM_OFFICER_NAME: SEPULVEDA, KRISTIN

PROJECT_TITLE: UCSF-Stanford Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN DIEGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Transforming the process by which academic researchers, healthcare leaders, clinicians, and other stakeholders (from patients to community) determine what research questions to ask is essential for addressing the health and healthcare needs of underserved populations. This transformation is only possible with an infrastructure that supports involvement in the research identification, selection, implementation, and dissemination processes. This application seeks to build on the efforts of a Federally Qualified Health Center located in a rural, border community in California to inform new approaches for supporting the knowledge transfer process through a clinical research network.

PI_NAMEs: AYALA, GUADALUPE X (contact);BELL, YVONNE

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Administrative Supplement;adverse pregnancy outcome;Advisory Committees;Awareness;Border Community;California;Characteristics;Clinical;Clinical Research;clinical research site;cohort;Cohort Studies;Collaborations;Collection;Common Data Element;Communities;community organizations;Contracts;County;Data;Data Collection;data harmonization;data interoperability;data sharing;diabetes control;diabetes management;Diabetes Mellitus;Education;Educational Status;Electronic Health Record;Equipment;Equity;Ethnic Origin;Evidence based practice;Federally Qualified Health Center;Future;Health;health disparity;health equity;Health Personnel;Healthcare;Healthcare Systems;Household;Human Resources;Immigration;implementation efforts;Income;Infrastructure;Intervention;Intervention Studies;Knowledge;Leadership;Measures;Mediation;Mental Health;novel strategies;Outcome;Participant;Patients;Personal Satisfaction;PhenX Toolkit;Poaceae;Policies;population based;Population Heterogeneity;postpartum care;Postpartum Period;pragmatic trial;Prenatal care;Procedures;Process;Protocols documentation;Provider;Race;Research;Research Activity;Research Infrastructure;Research Personnel;Research Priority;Resources;Rural;Sample Size;Sampling;secondary analysis;Site;social;social health determinants;suburb;System;Translations;treatment adherence;Treatment Effectiveness;Underserved Population;Woman

PROJECT_TITLE: Imperial County Clinical Research Network for Health Equity (Administrative Supplement)


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. PROJECT NARRATIVE The Centers of Excellence in Regulatory Science and Innovation (CERSI) program allows the U.S. Food and Drug Administration (FDA) to form extramural partnerships that foster robust and innovative research to develop new tools, standards, and approaches to assess the safety, efficacy, quality, and performance of FDA- regulated products, supporting regulatory decision-making and the overall mission of the FDA. Over the past seven years, the Yale-Mayo Clinic CERSI has pursued a series of innovative research projects that leverage real-world data sources to assess the safety, efficacy, quality, and performance of FDA-regulated products, informing regulatory decision-making as well as manufacturers, clinicians, and patients in support of optimizing patient-centered care, along with providing and supporting high-quality mentorship and training in regulatory science. The Yale-Mayo Clinic CERSI will continue this work, conducting high-quality, high-impact regulatory science research in priority areas identified by the FDA to modernize development and evaluation of FDA- regulated products, strengthen post-market surveillance and labelling of FDA-regulated products, and invigorate public health preparedness and response of FDA, patients, and consumers.

PI_NAMEs: ROSS, JOSEPH SOLOMON (contact)

PROGRAM_OFFICER_NAME: BATTLES, JESSICA JOY

PROJECT_TITLE: Yale-Mayo Clinic FDA Center of Excellence in Regulatory Science and Innovation (CERSI)


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The Johns Hopkins CERSI (JH-CERSI) represents a highly innovative collaboration between the world’s leading regulatory authority and the country’s largest research university. In this renewal, we combine the remarkable success of JH-CERSI since its inception with three new elements to accelerate knowledge and enhance impact in areas of incredibly high regulatory importance. There is not a moment to lose.

PI_NAMEs: ALEXANDER, G. CALEB (contact)

PROJECT_TITLE: Johns Hopkins Center of Excellence in Regulatory Science and Innovation


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MONROVIA

ORG_NAME: CHROMOLOGIC, LLC

PI_NAMEs: ROGERS, CLAUDE  (contact)

PROJECT_TERMS: 3-Dimensional;Animals;Award;Blood Vessels;Cell Survival;checkpoint therapy;drug development;Evaluation;Exposure to;Human;Immune checkpoint inhibitor;Immune response;Immune system;in vitro Model;in vivo;innovation;Interferon alpha;Interferons;Intestines;Investigation;Malignant - descriptor;Mediating;microRNA biomarkers;Modeling;Molecular;neoplastic cell;novel strategies;novel therapeutics;Organ;organ on a chip;Organoids;Outcome;Pharmacologic Substance;Pharmacotherapy;Phase;Physiological;Procedures;Production;programs;Prostate;Radiation;radiation effect;radiation response;Radiation therapy;radiation-induced tissue damage;response;Role;Science;Stimulator of Interferon Genes;Technology;Testing;Therapeutic;Tissue Model;Tissues;tool development;tumor;Up-Regulation;x-ray irradiation

PROJECT_TITLE: PHASE I AWARD - AN ORGAN-ON-VASCULARNET MODEL FOR IN VITRO EVALUATION OF RADIATION AND DRUG THERAPIES


NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SHREWSBURY

ORG_NAME: SPATIAL SURGICAL LLC

ORG_STATE: MA

PI_NAMEs: MONTY, NATHAN  (contact)

PROJECT_TERMS: 3-Dimensional;Ablation;Algorithmic Software;Area;Attention;cancer therapy;Cancerous;Carbon Dioxide;Cells;Cervical;Clinical;Collection;Colon;Colon Carcinoma;Colorectal Cancer;Custom;ergonomics;Eye;Fluorescence;Fluorescent Dyes;fluorophore;Hand;Lasers;lens;low and middle-income countries;Microscope;Modeling;Monitor;Operative Surgical Procedures;Optics;Oral;Performance;Phase;Photons;preservation;Production;Resource-limited setting;Solid Neoplasm;Spottings;Surgeon;Surgical Oncology;System;Technology;Testing;tumor;usability;Visualization

PROJECT_TITLE: Topic Number 431Cancer Treatment Technologies for Low-Resource Settings


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: MORGANTOWN

ORG_NAME: SOSTOS LLC

ORG_STATE: WV

PI_NAMEs: YE, QING  (contact)

PROJECT_TERMS: Acceleration;Award;Biological;Biological Markers;biomarker discovery;Blood specimen;cancer biomarkers;Cancer cell line;cancer diagnosis;Cancer Prognosis;Cells;cloud based;cloud software;Comparative Study;Computer software;Computing Methodologies;Data;Data Analyses;Data Security;Data Sources;drug development;drug repurposing;Encyclopedias;Ensure;Environment;feasibility testing;Goals;graphical user interface;Immune;improved;Malignant Neoplasms;Marketing;Methods;miRNA expression profiling;Modeling;multimodal data;multiple omics;Network-based;new technology;Non-Small-Cell Lung Carcinoma;novel therapeutics;optimal treatments;Outcome;Patients;Phase;Privacy;prototype;Recommendation;Safety;Sampling;scale up;single-cell RNA sequencing;Small Business Innovation Research Grant;Technology;Testing;The Cancer Genome Atlas;tumor;usability;user-friendly;Visualization

PROJECT_TITLE: Topic 464 Phase I Award: Network-Based Multimodal Data Analysis Cloud Software for Cancer Biomarker Discovery and Drug Development


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Health Services;Prevention;Radiation Oncology;Rare Diseases;Social Determinants of Health

ORG_CITY: TUCSON

ORG_NAME: LIGHT RESEARCH, INC.

ORG_STATE: AZ

PI_NAMEs: WILDER-SMITH, PETRA  (contact)

PROJECT_TERMS: Achievement;advanced disease;Animal Model;Contracts;Death Rate;Diagnosis;Disease Progression;Early Diagnosis;FDA approved;Health Care Costs;high risk;high risk population;Human;image guided;imaging system;innovation;Lesion;Light;low and middle-income countries;malignant mouth neoplasm;Malignant Neoplasms;Marketing;Modality;Morbidity - disease rate;mortality;Oral;Oral Stage;Oropharyngeal Squamous Cell Carcinoma;Patients;Phase;Photochemistry;premalignant;PUVA Photochemotherapy;Research;Resource-limited setting;screening;Screening for Oral Cancer;Small Business Innovation Research Grant;System;Technology;Time;United States National Institutes of Health

PROJECT_TITLE: FY24 SBIR Phase 2 RD Contract - Topic 431 Light Research, Inc.


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer

ORG_CITY: SOUTH SAN FRANCISCO

PI_NAMEs: JOBLING, MICHAEL  (contact)

PROJECT_TITLE: CBC LIBRARY SCREENING


ORG_CITY: CHICAGO

ORG_NAME: IIT RESEARCH INSTITUTE

ORG_STATE: IL

PI_NAMEs: MCCORMICK, DAVID  (contact)

PROJECT_TERMS: Adverse effects;Animals;base;Canis familiaris;Dose;Drug Kinetics;Hour;Organ;pre-clinical research;Rattus;Testing;Toxic effect;Toxicology

PROJECT_TITLE: TOXICOLOGY STUDIES IN RATS AND DOGS ADMINISTERED AIT-102


NIH_SPENDING_CATS: Bioengineering;Cancer

ORG_CITY: MIDDLETON

ORG_NAME: STANDARD IMAGING, INC.

ORG_STATE: WI

PI_NAMEs: HOLMES, SHANNON  (contact)

PROJECT_TERMS: beamline;Clinical;commercialization;Data Collection;design;design and construction;Dose;Dose Rate;dosimetry;Electrons;Frequencies;improved;ionization;Ions;irradiation;Measures;Methods;Modality;Monitor;novel;Performance;Phase;Physiologic pulse;pre-clinical;Protocols documentation;Protons;prototype;radiation detector;response;Signal Transduction;Small Business Innovation Research Grant;Structure;System;Testing;Time;time resolved data

PROJECT_TITLE: FY24 SBIR PHASE IITOPIC NO. 434PROJECT TITLE:  NOVEL NIST TRACEABLE IONIZATION CHAMBER FOR FLASH DOSIMETRY


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: GAITHERSBURG

PHR: NIDCD is committed to building and expanding our clinical trials program to promote the development of therapies and interventions to treat and prevent communication and other disorders in our core mission areas: hearing, balance, taste, smell, voice, speech, and language. NIDCD has a longstanding history of funding basic science research in these areas and encourages the translation of basic science discoveries to therapies that benefit patients through the conduct of clinical trials and other patient-oriented research.

PROJECT_TERMS: Area;Award;Basic Science;Clinical Data;Clinical Trials;Communication;Conduct Clinical Trials;Contract Services;Contractor;data management;data quality;Disease;Ensure;Equilibrium;experience;Funding;Hearing;high risk;Implementation readiness;improved;Intervention;Language;Life Cycle Stages;Mission;National Institute on Deafness and Other Communication Disorders;operation;patient oriented research;Patients;Performance;prevent;programs;Recording of previous events;Research;Smell Perception;Speech;Taste Perception;therapy development;Translations;United States National Institutes of Health;Voice;Work

PROJECT_TITLE: NIDCD Clinical Trials Program (CTP)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Vascular calcification and stiffness are hallmarks of diabetic vascular disorder, a prevalent cardiovascular complication in the Veteran's population that leads to increased morbidity and mortality. Disrupted circadian clock is a common issue in military personnel, which affects many of our Veterans. The proposal will establish a novel paradigm underlying circadian regulation of O-GlcNAcylation-mediated signaling in diabetic vascular calcification. The mechanistic insights learned from this proposal can not only advance our understanding of the basic mechanisms governing pathogenesis of diabetic vascular calcification, but also provide molecular insights into the development of novel strategy or drugs for prevention and therapy of these diabetic complications.

PI_NAMEs: CHEN, YABING  (contact)

PROJECT_TERMS: Acceleration;Affect;Animal Model;Animals;Aorta;ARNTL gene;Arteries;Blood Vessels;calcification;Cardiovascular system;Cell Physiology;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Clinical;Complication;Complications of Diabetes Mellitus;Darkness;Development;Diabetes Mellitus;diabetic;Diabetic Angiopathies;diabetic cardiomyopathy;Diabetic mouse;Disease Progression;Dose;Echocardiography;feeding;FOXO1A gene;Genes;Health;High Fat Diet;Hyperglycemia;improved;In Vitro;in vivo;insight;Knowledge;Learning;Light;Lipids;Mass Spectrum Analysis;Mediating;Military Personnel;military veteran;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;novel therapeutics;Outcome;Outcome Study;Oxidative Stress;Pathogenesis;Pathologic;Physiological;Post-Translational Protein Processing;Prevention;Proteins;Proteomics;Proto-Oncogene Proteins c-akt;Regulation;Reporting;Role;Signal Induction;Signal Transduction;Smooth Muscle Myocytes;Streptozocin;Time;tool;United States Department of Veterans Affairs;Up-Regulation;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Veterans

PROJECT_TITLE: Molecular Regulation of Vascular Calcification in Diabetes


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE: Antenna design remains one of the major challenges in the miniaturization of implantable medical devices. Conventional antenna designs are too large for next-generation miniaurized implants.This proposal will combine novel nanomaterial synthesis and innovative antenna design to create a remotely coupled and injectable antenna system. This new class of implantable antenna can be injected into the body, where they transform into a soft, conductive antenna. Once the antenna is injected, it will be able to remotely coupled with a much smaller antenna in the implantable medical device without physical attachment.

PI_NAMEs: FURSE, CYNTHIA M (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;Animal Model;biomaterial compatibility;Bionics;Body Surface;chemical property;Communication;Computers;Coupled;Data;data acquisition;design;Device Designs;Devices;Diagnostic;Disease;Electrodes;Electronics;Energy Transfer;Equipment;Evaluation;fabrication;Fatty acid glycerol esters;Foreign Bodies;Frequencies;Generations;Histology;Hydrogels;Implant;implantable device;improved;In Vitro;in vivo;in vivo imaging;Infection;Injectable;Injections;innovation;Intuition;Length;Mechanics;Medical;Medical Device;Medical Electronics;medical implant;Methods;Miniaturization;miniaturize;miniaturized device;Modeling;nanocomposite;nanomaterials;nanowire;next generation;novel;Operative Surgical Procedures;Outcome;Pathway interactions;Performance;Positioning Attribute;Property;Proxy;Publishing;Rattus;Research;response;Shapes;Signal Transduction;simulation;Skin;Solid;subcutaneous;Surgical complication;System;Techniques;Technology;Temperature;Testing;Toxic effect;transmission process;Utah;viscoelasticity;wireless

PROJECT_TITLE: Remotely Coupled Wireless Antenna System For Implantable Electronics

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Esophageal Cancer;Patient Safety;Prevention;Rare Diseases

ORG_CITY: Newton

ORG_NAME: LUMICELL, INC.

PI_NAMEs: FERRER, JORGE  (contact)

PROJECT_TERMS: Ablation;Agreement;Barrett Esophagus;Biopsy;Clinical Protocols;Clinical Research;Computer software;Data;design;Devices;Documentation;Dysplasia;Early Diagnosis;Endoscopes;Endoscopy;Esophageal Adenocarcinoma;Esophagus;Excision;Fluorescence;Fluorescent Probes;Gastroscopes;Guidelines;High grade dysplasia;Human;Image;imaging agent;imaging platform;In Situ;Incidence;Institutional Review Boards;Lesion;Light;Malignant neoplasm of esophagus;Malignant Neoplasms;meetings;Methods;Molecular;mortality;novel;Patients;premalignant;Process;Protocols documentation;Recommendation;research clinical testing;Research Design;Secure;Small Business Innovation Research Grant;System;Testing;Therapeutic;Time;Validation

PROJECT_TITLE: SBIR Topic 463: Clinical evaluation for early detection of esophageal cancer with a novel fluorescence endoscope and pegulicianine, a novel fluorescent probe


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PI_NAMEs: LEE, CHRISTOPH I (contact)

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Hematology;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: NARRATIVE Work from our groups has recently implemented a rapid, reliable and scalable test to quantify the functionality of the T cellular response against SARS-CoV-2. There is an urgent need to assess the persistence of cellular immunity, especially in immunocompromised patients (e.g. MM patients), to assess their level of protection. This study aims at establishing a scalable assay to assess cellular immunity, possibly aiding in nationwide booster strategies or passive antibody infusion support to protect these vulnerable population.

PI_NAMEs: GUCCIONE, ERNESTO  (contact);OCHANDO, JORDI ;PAREKH, SAMIR

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: 2019-nCoV;Address;Antibodies;Antibody Response;antigen detection;antigen-specific T cells;Bacterial Infections;Biological Assay;Biological Markers;Biotechnology;Blood;Blood specimen;booster vaccine;Bypass;cancer cell;Cancer Patient;Cells;Cellular Immunity;chemotherapy;Clinical;cohort;Cohort Studies;comorbidity;COVID-19;COVID-19 assay;COVID-19 complications;COVID-19 vaccination;CXCL10 gene;Data;Enrollment;Flow Cytometry;Goals;Hematologic Neoplasms;Hematology;Humoral Immunities;hypogammaglobulinemia;IL2 gene;Immune;Immune response;Immunity;Immunocompromised Host;Immunoglobulin G;Immunosuppression;Individual;Infection;Infusion procedures;Institutional Review Boards;Interferon Type II;Measures;Mediating;Methods;Modeling;Monitor;monocyte;Multiple Myeloma;Nature;neutralizing antibody;neutrophil;older patient;Oncology;Outcome;passive antibodies;Pathway interactions;patient population;Patients;Peptides;Peripheral Blood Mononuclear Cell;Phase;Plasma Cells;Population;Prevalence;prevent;Production;prophylactic;Proxy;Publishing;Quality Control;Recommendation;Recurrence;Reporting;response;RNA purification;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Sensitivity and Specificity;Social Distance;Specificity;Steroids;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Time;Vaccinated;Vaccination;vaccination strategy;Vaccinee;Vaccines;Validation;Viral;Viral Antibodies;Virus Diseases;Vulnerable Populations;Whole Blood;Work

PROJECT_TITLE: Implementation of a qPCR-based assay for the quantification of SARS-CoV-2-specific T cells in immunocompromised patients


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Acute;Adjuvant;Antigens;Biological;Biological Assay;Clinical;Clinical Trials;Clinical Trials Design;co-infection;comorbidity;Contracts;Data;Emerging Communicable Diseases;Evaluation;HIV Infections;HIV vaccine;HIV/AIDS;Immunologics;International;Knowledge;Laboratories;Monitor;Monoclonal Antibodies;National Institute of Allergy and Infectious Disease;programs;quality assurance;Quality Control;Reproducibility;Research;research clinical testing;Resources;Site;Specific qualifier value;Testing;vaccine candidate;vaccine platform;Vaccines;Virus

PROJECT_TITLE: External Quality Assurance Program Oversight Laboratory (EQAPOL)


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Climate-Related Exposures and Conditions;Infectious Diseases;Microbiome

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PI_NAMEs: YUAN, MENGTING MAGGIE (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TITLE: Legionella in soil: biotic and abiotic controls of pathogenicity


NIH_SPENDING_CATS: Cancer;HIV/AIDS

ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PI_NAMEs: WEST, JOHN T. (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE


ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PI_NAMEs: HEATH, JAMES R. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TITLE: PROJECT 1: TIME-Based Spatiotemporal Cancer Immunograms Predictive for Immunotherapy-Targeted Therapy Sequential Combinations


ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

PROJECT_TITLE: REAGENTS FOR IMMUNOLOGIC ANALYSIS OF COTTON RAT.


ACTIVITY: ZIA

ADMINISTERING_IC: AA

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

PI_NAMEs: LOVINGER, DAVID M (contact)

PROJECT_TERMS: Abstinence;Acetylcholine;Acetylcholinesterase;Acetylcholinesterase Inhibitors;Acute;Address;Adenosine;Adenosine A1 Receptor;alcohol and other drug;alcohol behavior;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;alcohol seeking behavior;alcohol use disorder;Alcoholic Intoxication;Alcohols;antagonist;Axon;Basal Ganglia;Behavior;Behavior Control;Brain;brain circuitry;Calcium;Cannabis;Cells;Chronic;Cognition;Corpus striatum structure;Coupling;Darkness;Decision Making;Dependence;desensitization;Dopamine;dopaminergic neuron;Dorsal;drinking;drinking water;drug action;Drug Exposure;drug misuse;drug of abuse;Electric Stimulation;Elements;Ethanol;extracellular;Frequencies;Future;Galantamine;Ganglia;Goals;Habits;Individual;Intake;interest;Intoxication;Investigation;Laboratories;Learning;Lobular Neoplasia;Measures;Mediating;Midbrain structure;Mus;neural;neural circuit;neuroadaptation;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;Neurosciences;Nicotinic Antagonists;nicotinic receptor beta2;Nicotinic Receptors;Nucleus Accumbens;Parkinson Disease;Pattern;Periodicity;Photometry;Physiologic pulse;Physiological;Physiology;Play;presynaptic;Presynaptic Terminals;Procedures;Process;Prosencephalon;PubMed;receptor;Receptor Activation;Receptor Inhibition;Research;Research Personnel;response;Role;Scanning;sensor;Slice;Stimulus;substance misuse;Synapses;Synaptic Transmission;System;Technology;Thalamic structure;Ventral Striatum

PROJECT_TITLE: Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of Abuse


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PI_NAMEs: HOLMES, ANDREW  (contact)

PROJECT_TERMS: addiction;alcohol effect;alcohol exposure;alcohol misuse;alcohol seeking behavior;alcohol use disorder;Alcohols;Amygdaloid structure;Animal Model;antagonist;Anxiety;Anxiety Disorders;anxiety reduction;Area;Behavior;Behavior Control;Behavioral;behavioral impairment;Binding;Biological Models;Brain;Chronic;Clinical;CNR1 gene;Cognitive;cognitive performance;Collaborations;comorbidity;Corpus striatum structure;cortico-limbic circuits;Data;design;Discrimination Learning;Dorsal;Drug Delivery Systems;Emotional disorder;Endocannabinoids;Enzymes;executive function;experience;experimental study;Exposure to;Extinction;fatty acid amide hydrolase;foot;Fostering;Fright;Genetic;Genetic Engineering;Genetic study;Genomics;Goals;Human;Impairment;improved;Individual;Individual Differences;inter-individual variation;interest;Interneurons;Laboratories;Laboratory mice;Learning;Lesion;Measures;Mediating;Mental Depression;mouse model;Mouse Strains;Mus;mutant;neglect;neural;neural circuit;Neurons;neuropsychiatric disorder;Neurosciences;novel;novel therapeutics;Pattern;Performance;Pharmaceutical Preparations;Pharmacology;Play;Post-Traumatic Stress Disorders;Prefrontal Cortex;Prevention;Procedures;programs;psychological trauma;Punishment;Recovery;Research;resilience;Reversal Learning;Rewards;Risk;Role;Scheme;Shock;Stimulus;Stress;stress disorder;substance misuse;Substance Use Disorder;System;Testing;Therapeutic;Training;Trauma;Trauma recovery;Work

PROJECT_TITLE: Mouse models of stress disorders and addiction


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric;Substance Misuse;Women's Health Research

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Adult;Adult women;Affect;aged;Agonist;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol use disorder;Alcohols;antagonist;Basal Ganglia;Behavior;Behavioral;Body Weight;Brain;Brain region;Breathing;cannabinoid drug;Caring;Cells;Child;cholinergic;Consumption;Control Groups;Corpus striatum structure;Deglutition;Development;Disease;Dopamine;drinking;Drug Design;drug misuse;Drug usage;Electric Stimulation;Electrophysiology (science);Enzymes;Event;Exhibits;experience;experimental study;Exposure to;Extinction;extracellular;Female;fetal;first grade;Future;Ganglia;Genetic;Goals;Grooming;habit learning;Habits;Health;Hormonal;Human;Impairment;improved;in vivo;Inhalation;Injections;interest;Interneurons;Lead;learned behavior;Learning;learning extinction;Learning Skill;Life;male;Maternal Behavior;Measures;Mediating;member;Midbrain structure;Modeling;Molecular;Mothers;Motor Skills;motor symptom;mouse model;Mus;neural circuit;Neurobiology;neuromechanism;Neuromodulator;Neurons;neuroregulation;Nicotinic Receptors;offspring;Operant Conditioning;Outcome;Performance;performance tests;Periodicity;postnatal;preference;Pregnancy;prenatal;Process;Public Health;pup;receptor;Receptor Activation;Regimen;response;Retrieval;Rewards;Rod;Role;Rotation;Scanning;sensor;sex;skills;Sleep;Sleep Architecture;Sleep disturbances;Slice;smoking cessation;social;Social Behavior;Social Interaction;Specificity;Speed;statistics;Stereotyping;Stimulus;Study Section;Substance Use Disorder;Symptoms;Synapses;Task Performances;Testing;therapy development;Third Pregnancy Trimester;Time;United States;varenicline;Weight;Women's Group

PROJECT_TITLE: Corticostriatal mechanisms of action learning and habit formation


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cocaine;Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: ALVAREZ, VERONICA A (contact)

PROJECT_TERMS: Absence of pain sensation;Affect;Agonist;alcohol behavior;alcohol use disorder;Behavioral;Behavioral Assay;Brain;cell type;Cells;Cocaine;cocaine related behaviors;cocaine self-administration;Cocaine use disorder;Compulsive Behavior;Corpus striatum structure;Cre-LoxP;Data;Development;Dopamine;Dopamine D2 Receptor;dopamine D3 receptor;dopaminergic neuron;DRD2 gene;drug action;drug misuse;Drug usage;Environment;Ethanol;Exploratory Behavior;Genetic;Globus Pallidus;Goals;Hyperactivity;In Situ Hybridization;In Vitro;in vivo;Individual;Intake;Knock-out;Laboratories;Locomotion;Mediating;mesolimbic system;Methods;Microdialysis;Midbrain structure;motivated behavior;mouse model;Mus;neural circuit;Neurobiology;Neurons;novel;Nucleus Accumbens;Opioid;optogenetics;Oxycodone;oxycodone self-administration;Pathway interactions;Periodicity;Pharmaceutical Preparations;Physiologic pulse;Physiology;Play;Population;postsynaptic;presynaptic;Psychological reinforcement;receptor;receptor expression;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Rewards;Role;Scanning;Stimulant;substance misuse;Synapses;Techniques;tool

PROJECT_TITLE: Synaptic mechanisms underlying reward seeking and compulsive drug use


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: FARMER, NICOLE  (contact)

PROJECT_TERMS: Adult;Affect;African American;African American population;Baptist Church;Behavior;Behavior Therapy;Blood;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;clinical center;Communities;Contracts;cooking;Data;Data Analyses;Data Collection;data management;design;Diet Habits;dietary;Disease;Eating;electronic consent;Electronics;Eligibility Determination;Evaluation;Event;Feasibility Studies;Focus Groups;Food;food security;Genetic Transcription;heart disease risk;Heart Diseases;Home;Hour;Intervention;Interview;Journals;Knowledge;Lead;Learning;Life Style;Location;Manuscripts;Medical History;Methodology;Modification;National Heart, Lung, and Blood Institute;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Occupational Therapist;Paper;Participant;Patient Self-Report;Pattern;Pennsylvania;Phase;phase 2 study;Pilot Projects;Preparation;Procedures;Process;programs;Protocols documentation;Publishing;Questionnaires;recruit;Research;Research Personnel;Resources;Risk Factors;Risk Reduction;Sampling;Services;skills;Stress;Surveys;symposium;telehealth;Training;Transportation;United States National Institutes of Health;virtual;virtual group;Visit;ward;Washington

PROJECT_TITLE: Dietary Behavior Intervention in African-Americans at Risk for Cardiovascular Disease


PI_NAMEs: WENDLER, DAVID S (contact)

PROJECT_TERMS: Address;Caring;clinical practice;Data;Decision Making;design;Emotional;emotional distress;experience;Face;Future;Goals;improved;interest;Interview;Medical;Medical Records;Methods;Patient Preferences;Patients;preference;Process;Research;shared decision making;surrogate decision making;Surveys;Work

PROJECT_TITLE: Surrogate Decision Making


PROJECT_TERMS: Address;Adult;Area;Attention;Benefits and Risks;Biological;Caring;Child;Childhood;Clinical;clinical care;Clinical Research;Collaborations;Compensation;Computers;Data;design;Empirical Research;Enrollment;Ensure;Ethics;Evaluation;Exposure to;Goals;Guidelines;health care availability;Individual;Informed Consent;Institutional Review Boards;Intervention;Intuition;Life;Medical Research;Methods;minimal risk;National Institute of Child Health and Human Development;Organizational Ethics;Participant;participant enrollment;Pediatric Research;Pediatrics;Pregnant Women;Prisoner;Procedures;Publishing;Regulation;Research;Research Subjects;Risk;risk minimization;Safety;Sampling;Scientific Advances and Accomplishments;Specimen;Spinal Puncture;Systematic Bias;Testing;Vulnerable Populations;Work

PROJECT_TITLE: Research and care with vulnerable individuals


PI_NAMEs: KIM, SCOTT  (contact)

PROJECT_TERMS: Address;Architecture;Benefits and Risks;Canada;Clinical;Collaborations;comparative;comparative effectiveness trial;comparison intervention;Consent;Data;Data Collection;Decision Making;design;Dialysis procedure;electronic medical record system;Ethical Issues;Ethics;evidence base;Goals;Individual;Informed Consent;interest;Intervention;Methods;minimal risk;personalized decision;Pragmatic clinical trial;pragmatic trial;Procedures;Randomized;Research;Risk;standard of care;Testing;trial design;Work;working group

PROJECT_TITLE: Ethics of Emerging RCT Designs: Risk analysis and informed consent


PROJECT_TERMS: Agreement;analytical method;Assisted Suicide;Attitude;Canada;Caring;Categories;Country;Decision Making;end of life;end of life care;Ethical Issues;Ethicists;Euthanasia;Evaluation;Human Rights;Inequity;Injections;Interview;Knowledge;Laws;Lawyers;Legal;Life;Literature;Medical;Medical Assistance;Medicine;Methods;Modeling;Monitor;Nature;Netherlands;neuropsychiatry;Patients;Persons;Pharmaceutical Preparations;Philosophy;Physician-Assisted Suicides;Physicians;preference;Reporting;Resort;Role;Surveys;Terminal Disease;trend

PROJECT_TITLE: End of life decision-making, euthanasia, and physician assisted suicide in persons with neuropsychiatric conditions


PROJECT_TERMS: Address;Adult;Affective;Benefits and Risks;cognitive enhancement;comparative effectiveness trial;Data;Decision Making;Drug usage;Emerging Technologies;Enhancers;Ethical Issues;experimental study;Government;Individual;Inequality;Informed Consent;Institution;Justice;Label;Logit Models;Medical Societies;Participant;Personal Satisfaction;Persons;Pharmacologic Substance;Physicians;Policy Making;Population;Publications;Reporting;Research Ethics;Risk;Sampling;side effect;social;Societies;Stimulant;therapeutic misconception;Universities

PROJECT_TITLE: Issues in Research Ethics


PROJECT_TITLE: Decision-making capacity in clinical and research settings


PROJECT_TERMS: Adult;Affect;Ambulatory Care Facilities;amino acid metabolism;Area;Behavior;Blood Tests;chronic pain;Clinical;clinical center;Clinical Research;Data;data management;dietary;Dietary intake;Dietary Practices;DNA Sequence Alteration;electronic consent;Electronics;Enrollment;food environment;food insecurity;Genes;Goals;Health;Heart;Hematology;Hemoglobin;Inflammation;Informed Consent;Interview;Journals;Manuscripts;Nutrient;nutrition;Outpatients;Oxidative Stress;Participant;Pathway interactions;Patient Recruitments;Peer Review;Personal Satisfaction;Persons;pre-clinical;Procedures;Process;Protocols documentation;Provider;psychosocial;recruit;research study;Resources;Risk;Role;Services;Severity of illness;Sickle Cell Anemia;social health determinants;Stroke;Surveys;telehealth;Telemedicine;United States National Institutes of Health;Venous blood sampling;Visit

PROJECT_TITLE: Observational Dietary Intake and Dietary Behvaiors among Adults Living with Sickle Cell Disease


PI_NAMEs: ASADA, YUKIKO  (contact)

PROJECT_TERMS: Adolescent;Adult;Attention;Behavioral;Characteristics;Childhood;Country;Data;Data Collection;Decision Trees;Development;Disability status;Disadvantaged;Disparity population;Education;Ethics;Ethnic Origin;Floods;Gender;Health;health difference;Health Disparities Research;health disparity;health inequalities;Hot Spot;Immigration;Income;intersectionality;Label;Life Cycle Stages;Literature;Longitudinal Studies;Measurement;Measures;Methodology;Methods;Modeling;Morbidity - disease rate;multilevel analysis;National Longitudinal Survey of Adolescent to Adult Health;Outcome;Patient Self-Report;Persons;Population;psychosocial;Race;Reduce health disparities;Research;Sampling;secondary analysis;Sex Orientation;social;social group;Societies;socioeconomics;sound;Surveys;Time;tool;United States

PROJECT_TITLE: Social group inequality and intersectionality


PROJECT_TERMS: Affect;Articulation;Behavior;Childhood;Ethics;Exercise;Goals;Health;Health and Retirement Study;health equity;health inequalities;Individual;Inequality;Inequity;Mathematics;Measurement;Measures;Modeling;models and simulation;older adult;Play;Policies;Role;simulation;social group;Societies;socioeconomics;theories;United States

PROJECT_TITLE: Egalitarianism and its empirical operationalization


PROJECT_TERMS: Articulation;Assisted Suicide;Canada;Communities;Demographic Survey;design;Disadvantaged;Economics;Feedback;General Population;Health;Health Fairs;Health Policy;Health system;high risk;Hour;improved;Individual;insight;Laboratories;Laboratory Study;Learning;Life;Medical;member;Methodology;Methods;Participant;Persons;Philosophy;Pilot Projects;Play;Population;prevent;Resources;Running;Science;social;Social Concepts;social disparities;Societies;sociodemographics;socioeconomics;System;Techniques;theories;Thinking;United States;United States National Institutes of Health;Work

PROJECT_TITLE: FairLab: Fairness Dialogues Field Laboratory


PI_NAMEs: MAKI, KATHERINE  (contact)

PROJECT_TERMS: Alcohol consumption;alcohol use disorder;Assessment tool;Behavior assessment;Behavioral;Biological;Biological Markers;Blood specimen;clinical phenotype;cognitive interview;Data;Data Collection;data management;Dental;Dental Hygiene;Enrollment;feasibility testing;Goals;Health behavior;Heavy Drinking;Incidence;Individual;Infection;Inflammation;Institutional Review Boards;Measures;Oral;Oral health;Pathologic;Patients;Periodontal Diseases;Population;Process;Questionnaires;Research;Risk;saliva sample;Salivary;Signal Transduction;Stress;Systemic disease;systemic inflammatory response;Tooth Diseases

PROJECT_TITLE: Quantifying Associations of Stress and Inflammation-Associated Oral Biomarkers with Oral Health, Oral Health Behaviors, Systemic Biomarkers & Clinical Phenotype in Individuals with Alcohol Use Disorde


PROJECT_TERMS: Canada;Data;Eligibility Determination;Financial Hardship;health care service;Health Services;Health Services Accessibility;Link;Medial;Medical Assistance;meetings;Netherlands;Newspapers;Paper;Persons;programs;Publishing;Radio;Reporting;Resources;Service provision;Social Work;standard care;Wait Time

PROJECT_TITLE: Medical assistance in dying and health services access in Canada


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease

PI_NAMEs: CHEN, WANJUN  (contact)

PROJECT_TERMS: Animal Model;Antigens;Apoptosis;Apoptotic;Attention;Autoimmune Diseases;autoimmune inflammation;Autoimmunity;Basic Science;Cells;Communicable Diseases;Dendritic Cells;design;Development;Disease;FOXP3 gene;Generations;Genes;Genetically Engineered Mouse;Glycolysis;Goals;human disease;IL2RA gene;Immune Tolerance;Immunity;Immunosuppression;Inflammation;Insulin-Dependent Diabetes Mellitus;interest;intraepithelial;Knockout Mice;Knowledge;Lymphocyte;Lymphoid;Lymphoid Tissue;Macrophage;malignant mouth neoplasm;Malignant Neoplasms;Mannose;Mediating;Metabolism;Mission;Molecular;mouse model;Mucous Membrane;National Institute of Dental and Craniofacial Research;Oral cavity;Oral mucous membrane structure;Pathogenesis;Pathway interactions;Peptides;Peripheral;Play;Production;Pulmonary Inflammation;Regulation;Regulatory T-Lymphocyte;Research;Role;Sepsis;Signal Transduction;System;T cell regulation;T-Lymphocyte;Therapeutic Intervention;Thymus Gland;Time;transcription factor;Transforming Growth Factor beta;Transforming Growth Factor beta Receptors;tumor;wound healing

PROJECT_TITLE: TGF-beta Regulation of Mucosal and Systemic T Cell Immunity and Tolerance


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: YAMADA, KENNETH  (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Address;Adhesives;Binding Sites;Biochemical;Biological Models;biophysical properties;cancer cell;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;cell motility;Cell-Cell Adhesion;Cells;Cellular biology;Chimera organism;Chimeric Proteins;Chondrocytes;collagenase 3;Complement;Complex;Conflict (Psychology);Cytoskeletal Proteins;Cytoskeleton;Degenerative polyarthritis;Disease;ECM receptor;Embryonic Development;Environment;Extracellular Matrix;Extracellular Matrix Proteins;Fascia;Feedback;Fibronectins;Funding;Future;Goals;Health;Human;Human Development;In Vitro;Integrin alpha5beta1;Integrins;Invaded;Lead;Malignant Neoplasms;Mammalian Cell;Manuscripts;Matrix Metalloproteinases;Mediating;Mentors;Methods;Microscopy;migration;Molecular;Molecular Biology;Motor;Mus;mutant;Myosin Type II;non-muscle myosin;Normal Cell;novel strategies;Pathogenesis;Pathologic;paxillin;Peptide Hydrolases;Physiological;Play;polypeptide;Process;Production;Productivity;programs;Protein Isoforms;Proteins;receptor;Regenerative Medicine;Regulation;Research;Research Project Grants;response;Role;Signal Pathway;Signal Transduction;Source;Suggestion;synergism;System;Testing;Tissue Engineering;two-photon

PROJECT_TITLE: Cell-Matrix Interactions and Migration


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Regenerative Medicine;Transplantation

PROJECT_TERMS: 3-Dimensional;Acinar Cell;Acinus organ component;Address;Adhesives;Apical;Architecture;Basement membrane;Cell Adhesion;cell motility;Cell Transplantation;cell type;Cell-Cell Adhesion;Cell-Matrix Junction;Cells;Characteristics;Collaborations;Complex;craniofacial;craniofacial development;craniofacial tissue;Cytoskeleton;Deposition;Development;Disease;Drosophila genus;egg;Electron Microscopy;Embryo;embryo cell;Embryonic Development;Endoplasmic Reticulum;Epithelial Cells;Epithelium;experimental study;Fibroblasts;Fluorescent in Situ Hybridization;Gene Expression;Gene Expression Alteration;Gene Expression Profile;gene induction;Genes;Gland;Goals;Golgi Apparatus;Image;Immunofluorescence Immunologic;in vivo;Integrins;Intramural Research;Kinesin;Laboratories;Location;Maintenance;Mammalian Cell;Mediating;membrane assembly;Membrane Proteins;Mesenchymal;Mesenchyme;Messenger RNA;Methods;Microscopy;Microtubules;Molecular;Morphogenesis;Motor;Mucous body substance;Mus;Muscle;Myoepithelial;Myoepithelial cell;National Institute of Dental and Craniofacial Research;Neural Crest;novel;Organ;organ growth;Parotid Gland;Positioning Attribute;Process;Production;Protein Biosynthesis;Proteins;Recording of previous events;Regulation;Research;restoration;RNA;Role;Salivary;Salivary Glands;Signal Transduction;single molecule;single-cell RNA sequencing;Site;Specificity;stem cells;Switch Genes;System;Testing;Tissue Engineering;Tissue Recombination;Tissue Transplantation;Tissues;transcriptomics;Ubiquitination;Vesicle;Writing

PROJECT_TITLE: Craniofacial Developmental Dynamics


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Pain Research

PI_NAMEs: RYBA, NICHOLAS J (contact)

PROJECT_TERMS: Animals;Behavior;Biology;bone;Brain;Cells;Code;Complex;craniofacial;Detection;detection platform;Discrimination;Electrophysiology (science);Environment;Esthesia;Eye;Face;Genetic;Goals;imaging approach;Individual;Inflammation;Injury;Logic;Meninges;Molecular;Muscle;Nasal cavity;Oral cavity;Pain;Pathway interactions;Peripheral;Physiological;Receptor Cell;response;Response to stimulus physiology;Sensory;sensory input;sensory stimulus;Signal Transduction;Skin;somatosensory;Specificity;Stimulus;Surface;System;Taste Perception;Tooth structure;Touch sensation;Work

PROJECT_TITLE: Sensory Biology


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Dental, Oral, and Craniofacial Disease;Diabetes;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PI_NAMEs: KULKARNI, ASHOK  (contact)

PROJECT_TERMS: Ablation;Acidity;Action Potentials;addiction;Adult;Affect;Afferent Neurons;allodynia;Analgesics;Animal Experiments;Animal Model;Back;Behavior;behavior test;Behavioral;behavioral response;behavioral study;Biochemical;Calcium;calcium indicator;Candidate Disease Gene;Capsaicin;Categories;Cell Death Process;cell injury;Cells;Chemical Injury;Chemicals;chronic neuropathic pain;chronic pain;chronic painful condition;Cinnamon - dietary;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Consultations;cost;Coupled;craniofacial development;CRISPR/Cas technology;Cyclin-Dependent Kinase 5;Cyclin-Dependent Kinase Inhibitor;Detection;Development;Devices;Diabetes Mellitus;Diabetic Neuralgia;differential expression;Disease;Distal;endoplasmic reticulum stress;Engineering;Environment;Enzymes;Etiology;Exhibits;experience;Face;Fire - disasters;foot;functional genomics;Ganglia;gene editing technology;Gene Expression;Gene Expression Regulation;gene-editing approach;Genes;genetic signature;Genetically Engineered Mouse;Goals;Green Fluorescent Proteins;Hand;Heart Diseases;Human;Hyperactivity;Hyperalgesia;Hyperglycemia;Hypersensitivity;Image;Immune response;in vivo;Individual;Inflammation;inflammatory pain;Ion Channel;Kinetics;Knock-out;Length;Light;Limb structure;Long term disability;Malignant Neoplasms;mammalian genome;Metabolic;metabolomics;Mitochondria;Molecular;mouse genome;mouse model;multiple omics;Mus;mustard oil;Nervous System Physiology;Neurodegenerative Disorders;neurodevelopment;neuron loss;neuronal cell body;neuronal excitability;Neuronal Injury;Neuronal Plasticity;Neurons;Neuropathy;neurophysiology;neurotransmitter release;Nociception;Nociceptors;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Non-Steroidal Anti-Inflammatory Agents;Olfactory Nerve;Opioid;Oral health;Organ Donor;orofacial;Orofacial Pain;overexpression;Oxidative Stress;Pain;Pain Measurement;Pain Research;pain sensitivity;pain signal;painful neuropathy;Paper;patch clamp;Pathway Analysis;Pathway interactions;Patients;Persistent pain;Phosphorylation;Phosphotransferases;Plants;Play;Process;Productivity;Property;Proteomics;Publishing;Quality of life;receptor;Refractory;Reporting;Research;Research Project Grants;response;Rheumatoid Arthritis;Rodent;Rodent Model;Role;Sampling;sensor;Signal Pathway;Signal Transduction;Societies;Spinal Cord;Spinal Ganglia;Stimulus;Structure;Structure of trigeminal ganglion;success;Techniques;Testing;tissue injury;Tissues;transcriptome;transcriptomics;Transgenic Mice;Transgenic Organisms;Trigeminal nerve structure;TRP channel;TRPV1 gene;Up-Regulation;Visualization;Work

PROJECT_TITLE: Characterization of Molecular Pathways in Chronic Pain Conditions


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics

PI_NAMEs: CHIORINI, JAY  (contact)

PROJECT_TERMS: adeno-associated viral vector;Antinuclear Antibodies;Apoptosis;Apoptotic;AQP1 gene;aquaporin 5;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Responses;Autoimmunity;Biology;Biopsy;Cannulations;Caspase;Cathepsins B;Cell Communication;Cell Culture Techniques;Cell Death;Cell Death Induction;Cell Physiology;Cells;Characteristics;Chloroquine;Chronic;Clinical;Complex;computerized tools;Data Set;Dependovirus;Development;differential expression;Disease;effective therapy;Epithelial Cells;Epithelium;Estradiol;Event;experimental study;Exposure to;extracellular;extracellular vesicles;Female;fodrin;Functional disorder;functional genomics;Future;G-Protein-Coupled Receptors;Gene Expression;Gene Expression Regulation;gene therapy;Gene Transfer;gene transfer vector;Genes;Gland;gland development;Goals;Gonadal Steroid Hormones;Human;Hydroxychloroquine;Hypergammaglobulinemia;image visualization;improved;In Vitro;indexing;Induction of Apoptosis;Liquid substance;live cell imaging;Lysosomes;male;Mediating;Membrane;Membrane Proteins;Messenger RNA;Methods;Minor salivary gland structure;Modeling;Molecular;mouse model;Movement;mRNA Expression;Mus;novel strategies;novel therapeutics;Orphan;Other Genetics;overexpression;particle;Pathogenicity;Pathway interactions;patient response;patient stratification;patient subsets;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Play;prevent;Production;Proteins;Proteomics;Reagent;Recombinants;response;Role;saliva secretion;Salivary;Salivary Glands;Sampling;Satellite Viruses;Serotyping;Serum;Severities;Sex Bias;Sialadenitis;Sjogren's Syndrome;Sodium-Potassium-Chloride Symporters;Subgroup;Symptoms;Syndrome;Testing;Therapeutic;Therapeutic Intervention;tool;transcriptomic profiling;transcriptomics;Transfection;Transgenic Mice;Tropism;uptake;vector;Virus;Work;Xerostomia

PROJECT_TITLE: Adeno-associated Virus Biology And Utilization For Gene Transfer


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Rare Diseases;Regenerative Medicine

PI_NAMEs: BUGGE, THOMAS H (contact)

PROJECT_TERMS: Acute;Alveolar Macrophages;Animal Model;Antifibrinolytic Agents;Bacteria;Binding;Biochemistry;Biology;Blood Coagulation Disorders;Blood Vessels;canine model;Canis familiaris;CD36 Antigens;Cell surface;Cells;Chinese Hamster Ovary Cell;Chronic;Clinical;Coagulation Process;Collaborations;Collagen;Collagen Receptors;Collectins;crosslink;Data;Denmark;Deposition;Development;Encapsulated;Endocytosis;Enzyme Precursors;Epithelium;experimental study;Extracellular Matrix;Extracellular Matrix Degradation;Extracellular Matrix Proteins;Factor XIII;Family;Family member;Fibrin;Fibrinogen;Fibrinolysis;Fibrinolytic Agents;Fibronectins;Glycoproteins;Health;Hemophilia A;Hemorrhage;Hemostatic Agents;Hemostatic function;Homologous Gene;Immobilization;improved;Incidence;Inflammatory;Injury;interest;knock-down;Lectin;Ligands;lipid nanoparticle;Liquid substance;Lung;lung injury;Macrophage;Malignant - descriptor;Malignant Neoplasms;mannose receptor;medical schools;member;Membrane Glycoproteins;Modeling;mouse model;Mus;Natural regeneration;novel;Operative Surgical Procedures;oral tissue;Pathologic;Pathology;Pathway interactions;Pattern recognition receptor;Peptide Hydrolases;Periodontal Diseases;Phenotype;Pilot Projects;Plasmin;Plasminogen;polymerization;Polymers;prevent;Proteins;Proteolysis;Proteomics;receptor;receptor function;Recombinants;Recurrence;Regulation;Research;Residual state;response;Saphenous Vein;Small Interfering RNA;stem;Therapeutic;Thrombin;Thrombolytic Therapy;Thrombospondin 1;thrombospondin 4;Thrombospondins;tissue injury;tissue regeneration;tissue repair;Tranexamic Acid;Transfection;triple helix;Universities;uptake;Urokinase Plasminogen Activator Receptor;Wild Type Mouse;Wisconsin

PROJECT_TITLE: Cell surface proteolysis in development, tissue repair, and malignancy


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

PI_NAMEs: MEZEY, EVA M. (contact)

PROJECT_TERMS: adult stem cell;Affect;Anemia;Autoimmune;Blood Cells;bone;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell;cancer therapy;Cartilage;Cell Lineage;Cell Separation;Cells;chemotherapy;Clinic;Disease;Environment;Erythrocytes;Fatty acid glycerol esters;fighting;follow-up;Growth Factor;healing;healthy volunteer;Hematopoiesis;Hematopoietic stem cells;Human;Immune;immune function;Immune system;immunoregulation;In Vitro;Inflammatory;Infusion procedures;interest;Iron;Knowledge;Learning;Leukocytes;Mesenchymal Stem Cells;Mus;novel therapeutics;Organ;Patients;Persons;Pharmaceutical Preparations;Population;Production;Radiation therapy;skeletal stem cell;Stromal Cells;System;Therapeutic;tissue culture;tissue regeneration;tissue repair

PROJECT_TITLE: Contribution of bone marrow cells to tissue regeneration, immune function and hematopoiesis


NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease

PROJECT_TERMS: 3-Dimensional;Actomyosin;Address;Adult;Antigen-Presenting Cells;Architecture;Basement membrane;Biochemical;Biophysics;cancer cell;Cell Adhesion;Cell Communication;Cell Culture Techniques;cell type;Cell-Matrix Junction;Cells;Collagen;Collagen Fibril;Collagen Type I;Complex;Confocal Microscopy;Dimensions;Embryonic Development;Encapsulated;Environment;Epithelial Cells;Event;Extracellular Matrix;Fibrillar Collagen;Fibroblasts;Fibronectins;Focal Adhesions;Gel;Genes;Goals;Homeostasis;Human;In Vitro;in vivo;insight;Integrin alpha2beta1;Integrin alpha5beta1;Integrins;interstitial;Invaded;Lateral;Macrophage;Malignant Neoplasms;Mammalian Cell;Mediating;migration;Modeling;Morphogenesis;Morphology;Motility;Mouse Cell Line;Nature;Neoplasm Metastasis;novel;Organ;Pathologic;Perforation;Play;Process;Property;Publishing;Recording of previous events;response;Role;Signal Transduction;spheroids;System;tissue culture;Tissue Engineering;Tissues;tumor;two-dimensional;Visualization;wound healing

PROJECT_TITLE: Matrix Organization and Dimensionality


NIH_SPENDING_CATS: Aging;Arthritis;Cancer;Chronic Pain;Dental, Oral, and Craniofacial Disease;Osteoarthritis;Pain Research

PROJECT_TERMS: 3-Dimensional;Actins;Adhesions;articular cartilage;Basement membrane;cancer cell;cartilage degradation;Cartilage Matrix;Cell Adhesion;cell behavior;Cell Communication;Cell surface;Cell Surface Receptors;Cells;Chondrocytes;Collaborations;Collagen;collagenase 3;Complement;Connective Tissue;Cytoskeleton;Degenerative Disorder;Degenerative polyarthritis;Dental Faculty;Development;Diagnostic;Disease;Early Endosome;Embryonic Development;Encapsulated;Endosomes;Environment;Enzymes;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Feedback;Fibronectins;Goals;Growth Factor;Head and Neck Cancer;Homeostasis;Human;In Vitro;in vivo;Integrin alpha5beta1;Integrins;Invaded;Joints;Length;Malignant - descriptor;Malignant Neoplasms;Matrix Metalloproteinases;Mediating;Mediator;Medicine;Microtubules;Modeling;Molecular;Morphogenesis;Myosin Type II;Neoplasm Metastasis;Normal Cell;novel;Oral health;Organelles;Oxidation-Reduction;pain receptor;pain signal;Pathogenesis;Pathologic;Pathologist;Patients;Peptide Hydrolases;Perforation;Phosphotransferases;polypeptide;prevent;Production;Protein Fragment;Proteins;Radiation;Radiation therapy;Reactive Oxygen Species;Recycling;Regulatory Pathway;Research;Research Project Grants;response;Role;Salivary Glands;Signal Induction;Signal Transduction;spheroids;Therapeutic;therapy development;Thinness;Tissues;trafficking;transcriptome sequencing;Tumor Cell Invasion;Universities;Vesicle;Xerostomia

PROJECT_TITLE: Cell-Surface Interactions in Pathogenesis


NIH_SPENDING_CATS: Autoimmune Disease;Dental, Oral, and Craniofacial Disease;Immunotherapy;Microbiome

PROJECT_TERMS: Animal Model;Antigens;Apoptosis;Autoimmune Diseases;autoimmune pathogenesis;Autoimmunity;Cells;Cellular Metabolic Process;Chronic;Development;Disease;effector T cell;Experimental Animal Model;Experimental Models;Future;Goals;Homeostasis;immune function;Immune response;Immune system;Immune Tolerance;Immunity;Immunotherapy;Inflammation;Knowledge;Macrophage;Malignant Neoplasms;Metabolic syndrome;Metabolism;microbiota;mucosal microbiota;Oral cavity;Pathogenesis;Patients;prevent;Regulation;Regulatory T-Lymphocyte;Role;T-Lymphocyte;Therapeutic;Transforming Growth Factor beta;Translating;Tumor Antigens

PROJECT_TITLE: Immunotherapy of  inflammation, autoimmune disease and cancer


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Pediatric

PI_NAMEs: TABAK, LAWRENCE A. (contact)

PROJECT_TITLE: Structure and Function of UDP-GalNAc:polypeptide alpha-GalNAc transferases


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Orphan Drug;Rare Diseases;Regenerative Medicine;Transplantation

PI_NAMEs: MAYS, JACQUELINE  (contact)

PROJECT_TERMS: 2019-nCoV;academic review;Acinus organ component;Affect;Allogenic;Autoimmune;Biological Assay;care providers;Cells;Chilblains;chronic graft versus host disease;clinical care;clinical center;Clinical Trials;Collaborations;Conduct Clinical Trials;COVID-19;curative treatments;Dental Care;Dermatology;Development;Diagnosis;Diffuse;Disease;Duct (organ) structure;Environment;Evaluable Disease;fecal microbiome;Fibrosis;Functional disorder;Goals;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;human model;Immune;Immune response;Immunobiology;Immunocompromised Host;Infiltration;Interferon Type I;Intervention;Investigation;Laboratory Study;Lesion;Link;longitudinal analysis;Lymphocyte Subset;Lymphocytic Infiltrate;metagenomic sequencing;Methods;mouse model;Mucous Membrane;Multi-Institutional Clinical Trial;National Institute of Dental and Craniofacial Research;Oral;oral care;Oral cavity;Oral Examination;Oral health;oral microbiome;Oral mucous membrane structure;Organ;pandemic disease;Parents;Pathogenesis;Pathogenicity;Pathologic;Patient advocacy;Patient Education;Patients;photobiomodulation;Physiological;Population;post-transplant;Process;Publishing;Quality of life;randomized placebo controlled trial;Research;Salivary Gland Diseases;Salivary Glands;Sampling;SARS-CoV-2 exposure;screening;Site;skin lesion;Streptococcus salivarius;System;targeted treatment;therapeutic target;Tissue Transplantation;Toes;tool;Translating;Transplant Recipients;Transplantation;United States National Institutes of Health;Veillonella parvula;viral RNA;Virus;Work

PROJECT_TITLE: Immunobiology and therapy of oral mucosal and salivary gland chronic graft-versus-host disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Lung;Lung Cancer;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: WERNER, ACHIM  (contact)

PROJECT_TERMS: Affect;Age;Anterior;autoinflammation;autoinflammatory;autoinflammatory diseases;Automobile Driving;Biochemical;Blood;Brain;CDC42 gene;Cell Differentiation process;Cell Fate Control;Cell Nucleus;Cells;Chick Embryo;Clinical;clinical investigation;Collaborations;Complex;craniofacial;craniofacial development;CUL3 gene;Cytoplasm;Cytoskeleton;Data;Defect;Development;developmental disease;Disease;Dissection;Ectoderm;Ectoderm Cell;Embryonic Development;Ensure;Enzymes;Future;Genetic;Genetic Transcription;Genotype;Goals;Head;Hematological Disease;Hematopoietic;Hematopoietic stem cells;High Prevalence;Human Development;human disease;human embryonic stem cell;Human Genetics;imaging approach;induced pluripotent stem cell;Inflammatory;inhibitor;insight;Lead;Ligation;Link;Malignant neoplasm of lung;member;men;Missense Mutation;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphology;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neural Crest;Neural tube;Neural Tube Closure;Neurons;never smoker;novel;novel therapeutic intervention;p21 activated kinase;Pathogenesis;Pathogenicity;Pattern;Post-Translational Protein Processing;programs;Property;Protein Isoforms;Proteins;Proteomics;Regulation;Reporting;Research;Role;screening;self-renewal;Signal Pathway;Signal Transduction;Site;Skeleton;Skin;Somatic Mutation;Spinal Muscular Atrophy;stem cells;Syndrome;Therapeutic;Translations;Ubiquitin;ubiquitin ligase;Ubiquitin-Activating Enzymes;Ubiquitination;Vacuole;Variant;X Chromosome

PROJECT_TITLE: Ubiquitin-dependent cell-fate decisions during human development and disease


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

PI_NAMEs: SAMARA, NADINE  (contact)

PROJECT_TERMS: Acetylgalactosamine;Active Sites;Affect;Alternative Splicing;Binding;Biochemical;biochemical tools;C-terminal;CA-15-3 Antigen;Catalysis;Catalytic Domain;Charge;Collaborations;college;Colorectal Cancer;Computing Methodologies;Development;developmental disease;Drosophila melanogaster;Enzymes;Epithelium;Family;flexibility;follow-up;Functional disorder;GALNT12 gene;Glycopeptides;Glycoproteins;glycoproteomics;glycosylation;Goals;Golgi Apparatus;Human;in vivo;Infection;Isoenzymes;Lectin;London;Malignant Neoplasms;Membrane;microbiota;Modeling;Modification;Morphology;Mucins;Mucous body substance;Mutation;National Institute of Allergy and Infectious Disease;National Institute of Dental and Craniofacial Research;Nervous System Disorder;Pathogenesis;Patients;Peptides;Polypeptide N-acetylgalactosaminyltransferase;preference;Property;Protein Isoforms;Proteins;Publishing;recruit;Regulation;RNA Splicing;Roentgen Rays;Role;Salivary Glands;Secretory Vesicles;Specificity;structural biology;Structure;Substrate Specificity;Testing;Toxoplasma gondii;Work

PROJECT_TITLE: Structural and functional studies of polypeptide N-acetylgalactosaminyltransferases (GalNAc-Ts)


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Lung;Lymphatic Research;Neurosciences

PROJECT_TERMS: Anatomy;Blood Vessels;Brain;brain parenchyma;Cells;Central Nervous System;Connective Tissue Cells;COVID-19;Cranial Nerves;Data;Elements;glossopharyngeal;Goals;Human;Infection;interstitial;Journals;Lymph;Lymphatic;Lymphatic Endothelial Cells;Lymphatic Endothelium;Lymphatic System;lymphatic vessel;Maps;Meninges;Mus;Nerve;Nervous System;Oral cavity;oral pathogen;Pathway interactions;Patients;Peripheral;Process;Publishing;Respiratory Center;Respiratory physiology;Route;Site;System;Travel;Trigeminal System;Vascular Endothelial Cell;Virus;Waste Products;wasting

PROJECT_TITLE: Lymphatic endothelial marker positive cells in the mouse and human nervous system


NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

PI_NAMEs: LIU, YUANYUAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Brain;Brain region;central sensitization;chronic pain;Clinical;Communicable Diseases;Communication;design;Disinhibition;Dissection;Electrophysiology (science);Herpes zoster disease;Hypersensitivity;Imaging Techniques;Light;mechanical allodynia;Medicine;Metabolic;Mind;mind/body;Mission;Nature;neural;neural circuit;Neurons;Neuropathy;Nociception;novel therapeutic intervention;Pain;Pain management;painful neuropathy;Pathway interactions;Patients;Pattern;Perception;Peripheral;Peripheral Nerves;Signal Transduction;single cell sequencing;somatosensory;Specificity;Spinal Cord;Tactile;transmission process;Trauma;Viral

PROJECT_TITLE: Somatosensation and pain


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases;Microbiome;Prevention

PROJECT_TERMS: adverse pregnancy outcome;Anabolism;Antibiotic Resistance;Biochemical;bioinformatics tool;Biological;Code;Colorectal Cancer;Communities;Disease;dysbiosis;Environment;Enzyme Inhibition;Enzymes;Genetic;Genome;glycosylation;glycosyltransferase;Link;Methods;Microbial Biofilms;microbial community;microorganism;Mouth Diseases;Nucleic Acids;Operon;oral bacteria;oral biofilm;oral microbiome;Pathway interactions;Periodontitis;Polysaccharides;prevent;Proteins;Role;Systemic disease

PROJECT_TITLE: Characterizing exopolysaccharide (EPS) biosynthesis pathways in oral biofilm


NIH_SPENDING_CATS: Antimicrobial Resistance;Dental, Oral, and Craniofacial Disease;Infectious Diseases

PROJECT_TITLE: Structural and functional studies of microbial O-glycosyltransferases that synthesize virulence factors


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

PI_NAMEs: EMIOLA, AKINTUNDE  (contact)

PROJECT_TITLE: Microbial exploration for new antimicrobial discovery


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Immunotherapy;Infectious Diseases;Kidney Disease

PI_NAMEs: AFZALI, BEHDAD  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Acute Renal Failure with Renal Papillary Necrosis;airway epithelium;American;Animal Model;antagonist;anti-fungal agents;Anti-Inflammatory Agents;autocrine;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;BACH2 gene;Behavior;Benchmarking;Biological;Biological Markers;Biology;CD4 Positive T Lymphocytes;CDK2 gene;Cell Lineage;cell motility;Cells;Cicatrix;Clinical;Collaborations;Communicable Diseases;Communication;Complement;Complement component C5;Complex;Computing Methodologies;COVID-19;COVID-19 patient;Data;Data Set;Discipline;Disease;EGR2 gene;Encephalitis;Enhancers;Environment;Epidemiology;Epigenetic Process;Epithelial Cells;Event;Failure;Folic Acid;Functional impairment;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;healing;Human;Immune;Immune system;Immunity;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;Infection;Inflammation;Inflammatory;inhibitor;Injury;injury and repair;insight;interest;Interferon Type I;Journals;JUN gene;Kidney;Kidney Diseases;Knowledge;Life;Link;Lymphocyte;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammals;Mediating;Mediator;Medical;Medicine;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myeloid Cell Activation;National Center for Advancing Translational Sciences;Nature;Neoplastic Cell Transformation;New England;novel;Occupations;Organ;Paper;paracrine;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;Physiology;Plasma;Polyglandular Autoimmune Syndrome Type I;post SARS-CoV-2 infection;prevent;Process;prognostic;programs;Psoriasis;Publications;Publishing;recruit;Regulation;Regulatory T-Lymphocyte;Renal function;Repression;Research;Research Personnel;Resolution;Resources;response;Risk;Role;Science;severe COVID-19;Shapes;Signal Induction;Signal Transduction;Skin;STAT3 gene;Syndrome;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;Therapeutic;Tissues;tool;transcription factor;transcriptome;Untranslated RNA;Vitamin D;Vitamin D Deficiency;Work

PROJECT_TITLE: Unravelling immunoregulatory circuits of tissue inflammation


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Estrogen;Fibroid Tumors (Uterine);Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: DIXON, DARLENE  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;analog;Archives;Benign;Biological;Biological Models;bisphenol A;Cadmium;carcinogenesis;cell growth;Cell Line;Cell Proliferation;Cells;Chemicals;Clinical;Clinical Treatment;Data;Development;Disease;disorder prevention;environmental agent;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Risk Factor;ESR1 gene;Estrogen Receptors;Estrogens;Exposure to;Extracellular Matrix;Fibroid Tumor;Fibrosis;gene induction;Genistein;Genomics;Goals;GPER gene;Growth;Growth and Development function;Growth Factor;Hormones;Human;Human Cell Line;improved;In Vitro;in vitro Model;in vivo;Knowledge;Leiomyoma;Ligands;Malignant Neoplasms;Membrane;Metals;Mission;Mitotic Activity;Modeling;Molecular;Morphology;Mus;Myometrial;myometrium;neoplastic cell;novel;overexpression;Pathogenesis;Pathway interactions;Patients;Phase;Phenotype;Phytoestrogens;Play;Premenopause;Prevention strategy;Preventive measure;Production;proliferative phase Menstrual cycle;prospective;Public Health;receptor;Receptor Protein-Tyrosine Kinases;reproductive tract;Research;Risk Factors;Rodent;Role;Sampling;Signal Pathway;Telomerase;Therapeutic Intervention;three dimensional cell culture;Tissue Sample;Tissues;Treatment Protocols;tumor;Tumor Expansion;tumor growth;tumorigenesis;Uterine Fibroids;Uterus;Woman

PROJECT_TITLE: Pathobiology Of Uterine Leiomyomas (fibroids)


NIH_SPENDING_CATS: Bioengineering;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: SCHMITT, CHARLES  (contact)

PROJECT_TERMS: climate change;Committee Members;Computer Models;Data;Data Discovery;data ecosystem;data harmonization;Data Management Resources;data repository;Data Science;Data Set;Development;digital;diverse data;Environment;Environmental Health;Environmental Risk Factor;epidemiology study;Funding;Genes;Goals;graph learning;Health;Intramural Research;Knowledge;knowledge graph;Language;large language model;Machine Learning;Manuals;Manuscripts;Metadata;Methodology;Methods;Modeling;National Institute of Environmental Health Sciences;Nutritional;Outcomes Research;Paper;Patient-Focused Outcomes;predictive modeling;Process;programs;reproductive system disorder;Research;Research Personnel;Resources;Science;stem;Strategic Planning;System;Text;Toxicology;Trust;United States National Institutes of Health;unstructured data;Wildfire;Work;working group

PROJECT_TITLE: Development of Data Science Methods


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: MESSIER, KYLE  (contact)

PROJECT_TERMS: Address;Air Pollutants;Air Pollution;Autoimmune Diseases;Bayesian Method;Cardiovascular system;Censuses;Chemicals;climate change;climate-related health;Complex;complex data;CYP1A1 gene;Data;Development;Dose;environmental chemical;Environmental Health;Exposure to;fine particles;Floods;gene regulatory network;Genetic Transcription;gradient boosting;ground water;Health;Health protection;Humidity;improved;Information Systems;Left;Maps;Messenger RNA;Methodology;Modeling;Molecular Target;North Carolina;novel;open source;Outcome;Outcomes Research;Pesticides;Process;Public Health;Research;Resolution;response;Risk;Risk Assessment;Science;Skin;social vulnerability;spatiotemporal;Statistical Methods;Temperature;Toxicokinetics;Toxicology;Up-Regulation;Update

PROJECT_TITLE: Spatiotemporal Health Analytics: Geospatial connections to toxicology


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: CRIZER, DAVID  (contact)

PROJECT_TITLE: Novel Tools and Approaches Research Program


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Contraception/Reproduction;Heart Disease;Hypertension;Networking and Information Technology R&D (NITRD);Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: BEVERLY, BRANDY  (contact)

PROJECT_TERMS: American;Animal Model;Animals;Area;Artificial Intelligence;Biological Assay;Biology;Biomedical Engineering;Blood Vessels;Cardiotoxicity;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Categories;Chemicals;Chronic;Clinical;Coculture Techniques;Collaborations;Communication;comorbidity;Complex;computational toxicology;Data;data integration;Databases;design;Development;Disease;Endothelial Cells;environmental chemical;Environmental Epidemiology;Environmental Exposure;Environmental Hazards;Environmental Health;evidence base;Exposure to;Failure;Functional disorder;Future;Goals;Government;hazard;Hazard Assessment;Health Disparities Research;Health Hazards;Human;Human Biology;human data;Hypertension;improved;in silico;In Vitro;in vivo;Industry;Injury;innovation;insight;International;Knowledge;Knowledge Management;Link;Manuscripts;Maps;Measures;Mediator;meetings;Mission;Modeling;Morbidity - disease rate;mortality;National Center for Advancing Translational Sciences;National Institute of Environmental Health Sciences;novel;Outcome;Peer Review;Physiological;Postdoctoral Fellow;Pre-Eclampsia;pregnancy disorder;programs;psychosocial stressors;Public Health;Publications;Qualifying;Quantitative Structure-Activity Relationship;Research;Risk;Scientist;screening;Skeletal Muscle;Societies;Structure;symposium;System;Testing;Tissue Engineering;Toxic effect;Toxicology;United States;Universities;Work

PROJECT_TITLE: Cardiovascular Health Effects Innovation Research Program


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Liver Cancer;Liver Disease;Rare Diseases;Women's Health Research

PI_NAMEs: PANDIRI, ARUN KUMAR  (contact)

PROJECT_TERMS: 3-Dimensional;agent orange;Air;Alveolar;Animals;Austria;Benzene;Bioinformatics;bioinformatics pipeline;Biological Assay;Biological Sciences;Breast Adenocarcinoma;Breeding;Bronchiolo-Alveolar Adenocarcinoma;Cancer Center;Cancer Etiology;carcinogenesis;carcinogenicity;Carcinogens;Cells;chemical carcinogenesis;Chemical Exposure;Chronic;Collaborations;Colon;Colorectal Cancer;Complex;contaminated water;CRISPR/Cas technology;Data;Data Analyses;data mining;data repository;Deposition;Development;DNA Sequence Alteration;early onset colorectal cancer;England;Environment;environment related cancer;Environmental Exposure;epigenomics;Etiology;Evaluation;exome;exome sequencing;Exposure to;Fatty acid glycerol esters;Fibroadenoma;Fructose;Genes;genomic data;Genomics;genotoxicity;Goals;ground water;hazard;Hazard Identification;Health;Health Sciences;Human;human data;improved;in silico;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;innovation;inorganic phosphate;insight;International;Italy;Joints;Knowledge;Laboratories;Liquid substance;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Manuscripts;material transfer agreement;Medical;Methods;MicroRNAs;Military Personnel;Mining;Mission;Modeling;Molecular;molecular pathology;Multiomic Data;multiple omics;Mus;Mutate;Mutation;National Institute of Environmental Health Sciences;next generation sequencing;Pathology;Pilot Projects;polyposis;Postdoctoral Fellow;predictive marker;Preparation;Primary carcinoma of the liver cells;Probability;programs;Proteomics;Public Health;Rattus;Registries;Renal Cell Carcinoma;Research;response;Rodent;Role;Sampling;Site;Structure;System;technical report;Technology;Testing;The Cancer Genome Atlas;Tissues;tool;Toxic effect;Toxicology;Trichloroethylene;tumor;tumor registry;United States Department of Veterans Affairs;Universities;University Health Services;Vinyl Chloride;western diet;whole genome;Work

PROJECT_TITLE: Carcinogenicity Health Effects Innovation Research Program


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PI_NAMEs: THOMAS, CRAIG  (contact)

PROJECT_TERMS: Biological;Biological Assay;Biology;Chemicals;Collection;cost;Development;Disease;disease model;drug discovery;Environment;Evaluation;fitness;Goals;improved;Industrialization;Libraries;Molecular;new chemical entity;novel;Phenotype;Play;Process;programs;Property;Research Personnel;Role;screening;small molecule;small molecule libraries;System;tool

PROJECT_TITLE: Novel small molecule library development


NIH_SPENDING_CATS: Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

PROJECT_TERMS: Adult T-Cell Leukemia/Lymphoma;B-Lymphocytes;Basic Science;Biological Assay;cancer type;Carcinoma;Caring;Clinical;Clinical Trials;combinatorial;Combined Modality Therapy;Cyclophosphamide;Disease;Doxorubicin;Drug Combinations;Ebola;Evaluation;Hematologic Neoplasms;Human;Immunotoxins;Informatics;inhibitor;Interleukin-2;Kyocristine;Malaria;Malignant Neoplasms;Methods;National Center for Advancing Translational Sciences;Non-Hodgkin's Lymphoma;novel;novel drug combination;Outcome;Outcome Study;Pharmaceutical Preparations;Phenotype;pre-clinical;Prednisone;Regimen;research clinical testing;Research Personnel;rituximab;screening;Signal Pathway;Technology;Vincristine;Visualization

PROJECT_TITLE: HTS enabled examination of drug combinations


NIH_SPENDING_CATS: Biotechnology;Charcot-Marie-Tooth Disease;Digestive Diseases;Eye Disease and Disorders of Vision;Genetics;Human Genome;Liver Disease;Neurodegenerative;Neurosciences;Pediatric;Peripheral Neuropathy;Rare Diseases

PI_NAMEs: INGLESE, JAMES  (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Age;alpha 1-Antitrypsin;alpha 1-Antitrypsin Deficiency;Alzheimer's Disease;Anti-malarials;Apoptosis;Applications Grants;assay development;Autoimmune Diseases;Autophagocytosis;autosome;Axon;Basic Science;Biogenesis;Biological Assay;Biological Models;Blindness;Calcinosis;Carbon;Categories;CD86 gene;Cell Cycle;Cell Line;Cells;Cellular Assay;Charcot-Marie-Tooth Disease;Chemicals;Child;Chromosome abnormality;Chromosomes;Chronic;Classification;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communicable Diseases;Communities;Congenital Disorders;Contracture;Cystic Fibrosis;Data Analyses;Defect;Demyelinations;Dental Enamel Hypoplasia;design;Development;Disease;Distal;DNA Sequence Alteration;drug discovery;early screening;Endoplasmic Reticulum;Engineering;environmental agent;Enzymes;Evaluation;Exanthema;experience;Extramural Activities;falls;Fatigue;Fibroblasts;Fission Yeast;functional genomics;Gametogenesis;Gene Library;Generations;Genes;Genetic;Genetic Screening;Genetic Transcription;genome editing;genome-wide;genomic locus;Genomics;Ghana;Glucose;Goals;hearing impairment;Hepatocyte;Hereditary Disease;Hereditary Motor and Sensory-Neuropathy Type II;high throughput screening;Human;Immune system;Immunity;Impairment;Individual;infancy;Infection;Inherited;inhibitor;innovation;Intellectual functioning disability;interest;Interferons;Investigation;Jordan;Kidney Calculi;Knowledge;Laboratories;Lead;Libraries;Life;Limb structure;Link;liver development;Liver diseases;Liver Dysfunction;loss of function;Lung Diseases;malaria infection;Malignant Neoplasms;Mediating;Membrane;Messenger RNA;Metabolic;method development;Microscopy;Missense Mutation;Modality;model organism;Modeling;Molecular;Molecular Biology;Molecular Conformation;monomer;Motor;multicatalytic endopeptidase complex;Multienzyme Complexes;Mus;Muscle Weakness;mutant;Mutation;Myositis;National Center for Advancing Translational Sciences;National Institute of Allergy and Infectious Disease;neglect;Nervous System Disorder;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Organism;Osteopenia;oxidation;Pain;Parents;Pathway interactions;Patients;Peripheral Nervous System Diseases;peroxisome;Pharmaceutical Preparations;pharmacologic;Phenocopy;Phenotype;PMP22 gene;Polymers;Production;programs;Protein Biosynthesis;Protein Conformation;protein expression;Proteins;Proteolysis;prototype;Quantitative Microscopy;Reporter;Reporter Genes;Reporting;repository;research and development;Research Personnel;response;Retinal Degeneration;Retinal Dystrophy;Retinitis Pigmentosa;RNA Interference;RNA Splicing;RPE65 protein;Science;Scientist;screening;Sensory;Services;Signal Transduction;Site;small molecule;small molecule libraries;Stress;Symptoms;System;T-Cell Activation;Technology;Testing;therapy development;Tissues;Toxin;trafficking;Translational Research;Translations;ubiquitin-protein ligase;Ubiquitination;Ulcer;Uniparental Disomy;Universities;Work;Yeasts

PROJECT_TITLE: Phenotypic Assay Design and Development for Rare and Neglected Diseases


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: 2019-nCoV;Active Sites;Adenylate Cyclase;Affinity;Agonist;Allosteric Site;Anabolism;Analytical Chemistry;antagonist;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;antimicrobial resistant infection;Antineoplastic Agents;Applications Grants;Aromatic Amino Acids;assay development;atrial natriuretic factor receptor B;Attenuated;beta-Lactamase;Binding;Biochemical;Biochemistry;Biological Assay;Brain natriuretic peptide;Carbapenems;Cell Differentiation process;Cells;Cessation of life;Chemicals;Cholesterol;Chorismate Mutase;chronic itch;Clinical;Collaborations;Colorado;Complex;Coupling;Cyclic AMP;Cyclic Peptides;design;Development;dietary;Disease;Doctor of Philosophy;drug discovery;Embryo;embryo cell;Enzyme Inhibitor Drugs;Enzymes;Erinaceidae;Evaluation;Extramural Activities;G-Protein-Coupled Receptors;Gene Expression;GTP-Binding Proteins;Guanylate Cyclase;high throughput screening;inhibitor;Interferons;Laboratories;Lactamase;Lactams;Lead;Link;Machine Learning;Malignant Neoplasms;Mammals;McCune-Albright Syndrome;medical schools;Messenger RNA;method development;Methods;microorganism;Missense Mutation;Modeling;Molecular Conformation;Morphology;mutant;Mutation;National Center for Advancing Translational Sciences;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;Natriuretic Peptides;Natural Products;Nerve;novel;Nucleic Acids;Osteitis Fibrosa Disseminata;palmitoylation;Pathway interactions;peptide analog;Peptide Library;Peptide Receptor;Peptides;Peripheral;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Phenylalanine;Plants;Process;programs;Protein Precursors;Proteins;prototype;Pruritus;Public Health;Quality of life;receptor;research and development;response;SARS coronavirus;SARS-CoV-2 inhibitor;Scientist;screening;Series;Signal Pathway;Signal Transduction;small molecule;small molecule libraries;Source;Spectrophotometry;Spinal Cord;synthetic peptide;Technology;Therapeutic;Tokyo;Transferase;Translations;transmission process;Tyrosine;United States National Institutes of Health;Universities;vaccine trial;Validation;Viral;Viral Nonstructural Proteins;virology;Virulence Factors;Virus;Work

PROJECT_TITLE: Target-based Assays and Screening Strategies for Chemical Probe and Therapeutic Lead Discovery


PI_NAMEs: HENDERSON, MARK  (contact)

PROJECT_TITLE: Modulators of Secreted ER Ca2+ Monitoring Protein (SERCaMP)


NIH_SPENDING_CATS: Biotechnology;Osteoporosis

PI_NAMEs: MARUGAN, JUAN  (contact)

PROJECT_TERMS: Agonist;assay development;Automobile Driving;Basic Science;Biology;Collaborations;Disease;drug candidate;drug development;drug discovery;Drug Kinetics;Evaluation;Extramural Activities;Family;Goals;Health;Human;Human Genome;improved;Informatics;lead optimization;male fertility;Modeling;mouse model;National Center for Advancing Translational Sciences;new technology;novel;novel therapeutics;Osteoporosis;Peptide Receptor;Pharmaceutical Chemistry;pharmacologic;Phenotype;Process;programs;Property;Rare Diseases;Relaxin;Reporting;Research;Research Personnel;screening;Screening Result;small molecule;small molecule therapeutics;Synthesis Chemistry;therapeutic development;tool;Translations;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Identification of novel agonist of the Relaxin family peptide receptor 2 (RXFP2) as potential new therapeutics for testicular maldescent


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Biotechnology;Brain Disorders;Cancer;Cardiovascular;Depression;Mental Health;Neuroblastoma;Neurosciences;Orphan Drug;Rare Diseases

PROJECT_TERMS: antagonist;assay development;Atherosclerosis;Biological Assay;Biology;Cell Line;Cells;Chronic stress;Collaborations;Disease;drug development;drug discovery;Extramural Activities;Follow-Up Studies;Goals;high throughput screening;Informatics;lead optimization;Mental Depression;Modeling;molecular modeling;Neuroblastoma;neuroblastoma cell;new technology;novel;PACAPR-1 protein;Pharmaceutical Chemistry;Phenotype;Process;Reporter;Research;Research Personnel;screening;small molecule;small molecule therapeutics;Synthesis Chemistry;Testing;therapeutic development;tool;Translations;United States National Institutes of Health;Validation;virtual screening;Work

PROJECT_TITLE: PAC1 receptor antagonists as potential treatments for depression and atherosclerosis associated with chronic stress


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Neurodegenerative;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: analog;Automobile Driving;Basic Science;Biological Assay;Cells;Collaborations;Disease;drug candidate;Enhancers;Extramural Activities;galactosylceramidase;Globoid cell leukodystrophy;Goals;Health;high throughput screening;Human;Human Genome;improved;induced pluripotent stem cell;Informatics;Lipids;Mass Spectrum Analysis;Modeling;mutant;National Center for Advancing Translational Sciences;Neurologic;novel;Oligodendroglia;Patients;Pharmaceutical Chemistry;pharmacologic;Process;programs;Psychosine;Rare Diseases;Reporting;Research;Residual state;screening;small molecule;small molecule therapeutics;therapeutic development;tool;Training;Translations;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: A Novel Cell-Based Assay to Identify Small Molecules for Galactocerebrosidase (GALC)


PI_NAMEs: HALL, MATTHEW  (contact)

PROJECT_TERMS: analog;Automobile Driving;Base Pairing;Basic Science;Chemicals;drug candidate;Drug Kinetics;Dystonia;early onset;Genes;Health;Human;Human Genome;improved;Inclusion Bodies;inhibitor;Lead;Membrane;mutant;Mutation;National Center for Advancing Translational Sciences;novel;Pathology;Pattern;Pharmaceutical Chemistry;pharmacologic;Primary Dystonias;programs;Property;Proteins;Rare Diseases;Research;Series;small molecule;tool;TorsinA;Translations

PROJECT_TITLE: qHTS to Identify Inhibitors of DYT1 Inclusion Formation


PROJECT_TERMS: anti-cancer treatment;Apoptotic;Automobile Driving;Basic Science;Binding;Biological Assay;Chemicals;Chemistry;Clinical;Data;DNA Damage;drug candidate;Drug Kinetics;Environment;Family;Fluorescence;Health;Human;Human Genome;improved;inhibitor;lead optimization;lead series;Malignant Neoplasms;Mass Spectrum Analysis;member;National Center for Advancing Translational Sciences;novel;overexpression;pharmacologic;PPM1D gene;Prognosis;programs;protein phosphatase 2C;Protein Serine/Threonine Phosphatase;Proteins;Rare Diseases;Reporter;Research;response;scaffold;screening;small molecule;Surface Plasmon Resonance;Testing;therapeutic development;tool;TP53 gene;Translations;tumor growth;Work

PROJECT_TITLE: qHTS to Identify Activators and Inhibitors of Wip1


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Antineoplastic Agents;Binding;Biological Assay;Blood - brain barrier anatomy;cancer cell;cancer type;Cell Line;Cells;Homologous Gene;Human Activities;Libraries;Membrane;neoplastic cell;overexpression;Pharmaceutical Preparations;small molecule;solute;Therapeutic;Tissues;Translations;Zebrafish

PROJECT_TITLE: qHTS to Identify Substrates of P-glycoprotein (P-gp) and Collateral Sensitivity agents of P-gp-expressing Cancer Cells


NIH_SPENDING_CATS: Biotechnology;Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PI_NAMEs: RAI BANTUKALLU, GANESHA  (contact)

PROJECT_TERMS: 3-Dimensional;aldehyde dehydrogenases;Aldehydes;Anabolism;analog;Biological;Biological Assay;cancer cell;Cancer cell line;cancer drug resistance;Cancer Relapse;cancer stem cell;Carboxylic Acids;Cells;Cyclophosphamide;cytotoxicity;design;Development;Dopamine;Drug Kinetics;Drug Metabolic Detoxication;Enzymes;Ethanol Metabolism;Exhibits;gamma-Aminobutyric Acid;high throughput screening;Homeostasis;Human;in vivo;inhibitor;Isoenzymes;Malignant neoplasm of ovary;member;Metabolism;miniaturize;Neurotransmitters;novel;oxidation;Oxidative Stress;Paclitaxel;Pharmaceutical Chemistry;Prognosis;quinoline;Research;Resistance;Series;small molecule;spheroids;Structure-Activity Relationship;Therapeutic;therapeutic target;Tretinoin;Work

PROJECT_TITLE: Selective Inhibitors of ALDH1A1


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurodegenerative;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: autosome;Cells;Disease;enzyme replacement therapy;Gaucher Disease;Genes;glucosylceramidase;Glucosylceramides;high throughput screening;induced pluripotent stem cell;large scale production;Lead;Lipids;lysosomal proteins;Lysosomes;Molecular Chaperones;molecular modeling;mutant;Mutation;Patients;Phenotype;Physiological;prevent;Proteins;Reporting;small molecule;Study models;Testing;Therapeutic;trafficking;Variant;virtual screening

PROJECT_TITLE: Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Epilepsy;Neurodegenerative;Neurosciences

PROJECT_TERMS: ABL1 gene;Alzheimer's Disease;Alzheimer's disease model;Amyloid beta-Protein;Automobile Driving;Basic Science;Biological Assay;blood-brain barrier penetration;Clinic;cognitive recovery;drug candidate;Drug Kinetics;Enzymes;Epilepsy;Evaluation;Exposure to;Health;high throughput screening;Human;Human Genome;Impaired cognition;improved;inflammatory marker;inhibitor;mouse model;National Center for Advancing Translational Sciences;Neurodegenerative Disorders;Neurons;novel;pharmacologic;Phosphotransferases;pre-clinical;programs;Rare Diseases;Research;small molecule inhibitor;Structure;Structure-Activity Relationship;tool;Translations

PROJECT_TITLE: HTS to Identify Inhibitors of c-Abl kinase for the Potential Treatment of Epilepsy and Neurodegenerative diseases


PROJECT_TERMS: analog;Animals;Brain;cancer cell;Cancer Model;cancer type;Cell Nucleus;Chemicals;Complex;Critical Pathways;Disseminated Malignant Neoplasm;Goals;high throughput screening;In Vitro;in vivo;inhibitor;mouse model;Nature;Neoplasm Metastasis;neoplastic cell;neurotoxicity;Nuclear;Patients;Penetration;Prevalence;Solid;Structure;Structure-Activity Relationship;tool;Translations;Tumor Cell Invasion

PROJECT_TITLE: Progression of Metarrestin that Reduces PNC Prevalence and Elucidation of its Mechanism of Action


PROJECT_TERMS: Agonist;analog;assay development;Automobile Driving;Basic Science;Binding;Biological Assay;Biology;Collaborations;Cryoelectron Microscopy;Data;Disease;drug candidate;drug development;drug discovery;Drug Kinetics;Extramural Activities;Formulation;Goals;Health;Human;Human Genome;improved;in vitro Assay;in vivo;in vivo Model;Informatics;Lead;lead optimization;Metabolic;Modeling;National Center for Advancing Translational Sciences;new technology;novel;Pharmaceutical Chemistry;pharmacologic;Phenotype;Process;programs;Rare Diseases;receptor;Relaxin;Research;Research Personnel;screening;small molecule;small molecule therapeutics;Synthesis Chemistry;Testing;therapeutic development;tool;Translations;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Small molecule agonists of the relaxin 1 receptor


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

PROJECT_TERMS: Animal Model;antagonist;Bipolar Disorder;Catalepsy;Dopamine D2 Receptor;DRD2 gene;efficacy study;Evaluation;Gilles de la Tourette syndrome;Human;improved;in vivo;Intervention;Lead;Legal patent;novel;Pharmaceutical Chemistry;pharmacologic;preclinical development;Property;Psychoses;Research;Schizophrenia;Series;side effect;Structure-Activity Relationship;Translations

PROJECT_TITLE: Discovery of Novel Modulators of the Human D2 Dopamine Receptor


NIH_SPENDING_CATS: Autoimmune Disease;Orphan Drug;Rare Diseases

PROJECT_TERMS: Agonist;antagonist;Antibody Activation;Autoimmune Diseases;Automobile Driving;Basic Science;Binding;Biological Assay;Cells;Cyclic AMP;Development;Disease;Dose;drug candidate;Germ-Line Mutation;Goals;Graves' Disease;Health;Human;Human Genome;Hyperthyroidism;improved;Lead;lead optimization;Metabolic;mouse model;National Center for Advancing Translational Sciences;novel therapeutics;Pathogenesis;Patients;Pharmaceutical Preparations;pharmacologic;Population;Prevalence;Production;programs;Rare Diseases;receptor function;Receptor Signaling;Research;response;scale up;small molecule;Testing;Therapeutic;thyroid associated ophthalmopathies;Thyroid Gland;Thyroid Hormones;Thyroid stimulating immunoglobulins;Thyrotropin Receptor;Tissues;tool;Translations;Treatment Protocols;Vision

PROJECT_TITLE: Assay for Small-Molecule Antagonists of the TSH Receptor


NIH_SPENDING_CATS: Cancer;Rare Diseases

PI_NAMEs: SHEN, MIN  (contact)

PROJECT_TERMS: advanced disease;Antineoplastic Agents;Automobile Driving;Autophagocytosis;Basic Science;Biochemical;biological adaptation to stress;Biological Assay;Biological Availability;cancer cell;Cell Physiology;Cells;Development;Disease;disease model;drug candidate;Enzymes;Growth;Health;Human;Human Genome;improved;inhibitor;insulin signaling;kinase inhibitor;Lipids;Malignant Neoplasms;Modality;mutant;National Center for Advancing Translational Sciences;novel;pharmacokinetics and pharmacodynamics;pharmacologic;Phosphatidylinositols;Phosphotransferases;Play;pre-clinical;programs;Proliferating;Rare Diseases;Research;Role;Signal Transduction;small molecule inhibitor;Therapeutic;tool;TP53 gene;Translations;Work

PROJECT_TITLE: Identification of Inhibitors of the Lipid Kinase PI5P4Ka/B as Potential Anti-Cancer Agents


NIH_SPENDING_CATS: Cancer;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

PROJECT_TERMS: analog;Animal Cancer Model;Attenuated;Biological Assay;Biology;Cancer Cell Growth;Cancer Etiology;Cessation of life;Chemicals;Death Rate;Disease;Dose;Drug Kinetics;Enzymes;experimental study;Female Genital Neoplasms;Fibroblasts;Greater sac of peritoneum;Human;improved;In Vitro;in vivo;inhibitor;Investigational Therapies;knock-down;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;member;Metabolic;Mus;Mutation;Neoplasm Metastasis;Nicotinamide N-Methyltransferase;Ovary;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Prognosis;programs;Property;Quality of life;Recombinants;Recurrence;Reporting;Role;Serous;Site;Structure;Symptoms;Therapeutic;therapeutically effective;TP53 gene;tumor;tumor heterogeneity;Woman

PROJECT_TITLE: qHTS to Identify Inhibitors of NNMT1


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

PROJECT_TERMS: Agonist;analog;assay development;Biological Assay;Biology;Cells;Collaborations;Disease;drug development;drug discovery;Evaluation;Extramural Activities;G-Protein-Coupled Receptors;Goals;Informatics;Lead;lead optimization;Measures;Metabolic;Modeling;mouse model;Multiple Sclerosis;nerve damage;Neurons;new technology;novel;Optic Nerve;Pharmaceutical Chemistry;Phenotype;Process;Research;Research Personnel;screening;small molecule;small molecule therapeutics;Structure-Activity Relationship;Synthesis Chemistry;therapeutic development;tool;Translations;Traumatic Brain Injury;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Medicinal chemistry campaign to synthesize synaptamide analogs (GPR110)


NIH_SPENDING_CATS: Cancer;Orphan Drug;Rare Diseases

PI_NAMEs: SIMEONOV, ANTON  (contact)

PROJECT_TERMS: beta catenin;Biological Assay;Biological Process;cancer immunotherapy;cancer type;colon cancer cell line;Development;Disease;Eukaryota;Excision;Family;Genes;Glioblastoma;high throughput screening;Human;human disease;in silico;Inflammatory;inhibitor;interest;Knockout Mice;Lead;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Melanoma;mouse model;Neurodegenerative Disorders;NF-kappa B;overexpression;Pathway interactions;Play;Post-Translational Protein Processing;prospective;Proteins;Role;screening;Signal Pathway;small molecule;small molecule inhibitor;Structure;T-Cell Activation;Testing;TP53 gene;Transforming Growth Factor beta;tumorigenesis;Ubiquitin;ubiquitin isopeptidase;ubiquitin-specific protease;Ubiquitination;Virus Diseases;Work

PROJECT_TITLE: Identification of small molecule inhibitors of USP15


NIH_SPENDING_CATS: Biotechnology;Immunotherapy

PROJECT_TERMS: Automobile Driving;Binding;Biological Assay;Clinical Trials;Collaborations;Communities;Cryoelectron Microscopy;Development;Disease;drug discovery;Extramural Activities;Fostering;General Population;high throughput screening;Host Defense;human disease;Immune checkpoint inhibitor;Immunomodulators;improved;In Vitro;in vivo;Informatics;Ligands;Link;Macrophage;Molecular Medicine;molecular modeling;novel;novel therapeutics;peptide analog;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Process;Publications;recruit;Research;Research Personnel;Resources;screening;Signal Transduction;Site;small molecule;Structure;Surface;synthetic peptide;Translations;tumor;United States National Institutes of Health;Work

PROJECT_TITLE: CD206 activators as novel immunomodulators


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases

PROJECT_TERMS: Animals;Anti-viral Agents;Antibodies;Biological;Biological Assay;Blood - brain barrier anatomy;Brain;candidate identification;Chemicals;Clinical Trials;Collaborations;Collection;design;Development;Disease;drug repurposing;efficacy study;Failure;Fatality rate;Hamsters;HepG2;Human;In Vitro;Infection;inhibitor;Libraries;Luciferases;Modeling;Mus;National Center for Advancing Translational Sciences;novel;Pharmaceutical Chemistry;pharmacologic;Pharmacologic Substance;Phenotype;prevent;Prophylactic treatment;Quantitative Structure-Activity Relationship;Rabies;Rabies virus;Recombinants;Reporter;Research;screening;Series;Site;small molecule;small molecule inhibitor;small molecule therapeutics;Therapeutic;Therapeutic Intervention;Toxic effect;Translations;Triage;Vaccination;Viral;viral transmission;Work

PROJECT_TITLE: qHTS to Identify Inhibitors of Rabies Virus