ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative The proposed research aligns with the priority objectives and goals in the HIV National Strategic Plan for the United States: A Roadmap to End the Epidemic 2021–2025, which states that “[…] to successfully achieve the goal of ending the HIV epidemic, issues such as discrimination and systemic racism that contribute to differences in health care quality and access […] and lead to ongoing disparities among racial, ethnic, and sexual and gender minority populations, must be addressed.” By targeting structural racism and discrimination at the organizational (clinic) and systems (provider/staff) levels, we will indirectly impact its downstream manifestations affecting processes and co-morbidities for Black, Indigenous, and People of Color at the individual level. Findings will support the creation of a manual for SRD reduction and racial equity promotion that may be adopted by other RWHAP-funded clinics and facilities serving marginalized groups.

PI_NAMEs: BROWNE, FELICIA AMIRA;LELUTIU-WEINBERGER, CORINA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Accountability;Address;Adopted;Affect;anti-racism;Anxiety;Area;Behavior;Black race;Black, Indigenous, People of Color;Caring;Characteristics;Clinic;clinical care;Cluster randomized trial;comorbidity;Consolidated Framework for Implementation Research;Data Collection;Discrimination;Disparity;distrust;Education;Ensure;Environment;Epidemic;Equity;equity, diversity, and inclusion;ethnic minority population;Ethnic Origin;evidence base;experience;Feedback;Fostering;Funding;Gender;gender minority group;Geography;Goals;Health;health care quality;health difference;Health Personnel;Health Policy;Health Promotion;Healthcare;HIV;HIV/AIDS;improved;Incidence;indexing;Individual;individual patient;Institutional Racism;Intervention;Job Satisfaction;Justice;Latinx;Leadership;Manuals;marginalized population;Medical;Mental Depression;Mental Health;Mission;Modality;Modification;Monitor;multi-racial;Outcome;Patients;perceived discrimination;Personal Satisfaction;Persons;Police;Policies;Prejudice;Prevention;primary outcome;Process;programs;Provider;Race;racial discrimination;Racial Equity;racial minority population;racism;Randomized;Recording of previous events;Reporting;Research;response;secondary outcome;Services;sexual minority group;Sexuality;Site;social stigma;Societies;socioeconomics;Staff Attitudes;Strategic Planning;Structural Racism;Surveys;System;Testing;theories;Training;Transcend;Trauma;United States;uptake;Vision

PROJECT_TITLE: Ending the HIV Epidemic with Equity: An All-facility Intervention to Reduce Structural Racism and Discrimination and Its Impact on Patient and Healthcare Staff Wellbeing


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The proposed studies will investigate the regulation of ferroptosis, a unique non-apoptotic cell death mechanism. This knowledge will enhance our understanding of this fundamental biological process. This research is relevant to public health because it may help identify new ways to manipulate ferroptosis to treat disease.

PI_NAMEs: DIXON, SCOTT  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Biochemical;Biological Process;Biology;biomarker identification;cancer therapy;Cell Death;Cell Death Process;Cell membrane;Cells;Chemicals;Coenzyme A Ligases;Complex;Cystine;Data;deprivation;Development;Disease;Endoplasmic Reticulum;Enzymes;Family member;functional genomics;Genes;Genetic;Genetic Screening;genome-wide;Genomics;Goals;Health;Human;Imaging Device;imaging modality;Imaging Techniques;improved;In Vitro;in vivo;innovation;insight;Iron;Knowledge;Lipid Peroxides;lipidomics;Lipids;Membrane;Metabolic;Mitochondria;Molecular;molecular marker;Morphology;Nerve Degeneration;novel;Pathology;Pharmaceutical Preparations;Phospholipids;Process;Production;Public Health;Regulation;Reperfusion Injury;Research;response;Role;Shapes;Signal Transduction;small molecule inhibitor;Stimulus;Technology;Testing;tool;Toxic effect;transcriptome sequencing;Transmission Electron Microscopy;tumor;Tumor Suppression

PROJECT_TITLE: Characterizing the Regulation of Ferroptosis

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT 2: NARRATIVE ER+ breast tumors often fail to respond to endocrine therapies. There is a need for combinations of targeted drugs and endocrine therapies that block distinct escape mechanisms for the cells to become resistant. The proposed studies will address the epigenetic mechanisms of bromodomain signaling on endocrine therapy responses in ER+ breast cancer.

PI_NAMEs: FRIETZE, SETH E (contact)

PROJECT_TERMS: Acceleration;Acetylation;adjuvant endocrine therapy;Binding;Biological Markers;Breast Cancer Cell;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;Bromodomain;Calorimetry;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer therapy;Cell model;cell type;Cells;ChIP-seq;Chromatin;clinical application;clinically relevant;Data;Development;Disease;Drug Targeting;druggable target;Effectiveness;Elements;Endocrine;Enhancers;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;ESR1 gene;Estrogen Antagonists;Estrogens;Exhibits;gene regulatory network;Genes;Genetic Transcription;Genome;Genomics;Histone Acetylation;Histones;hormone therapy;improved;Individual;inhibitor;insight;Ligand Binding;Ligands;Link;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metastatic/Recurrent;Modality;Molecular;novel;Organoids;Outcome;Pathway interactions;Patients;Pattern;Peptides;Phase;Phenotype;Post-Translational Protein Processing;precision medicine;preference;Prognosis;programs;Proteins;Publishing;Reader;Recurrence;Refractory;Relapse;Resistance;resistance mechanism;response;Response Elements;Role;RUNX1 gene;Signal Transduction;System;Tamoxifen;targeted treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Treatment Failure;treatment response;treatment risk;tumor;Variant;Women's mortality;Work

PROJECT_TITLE: Project 2: Bromodomains as Epigenetic Modulators of Endocrine Responsiveness in ER+ Breast Cancer


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Transplantation

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Retinal progenitor sheet transplants into rodents with retinal degeneration (RD) have been shown to make nerve connections to the recipient RD retina, and to generate basic visual responses to light in the superior colliculus (SC, a primary target of retinal ganglion cells). However, we still do not know whether and to what degree complex, higher-level visual processing is restored in visual cortex. The objectives of this study are to investigate to what extent rat fetal- and hESC-derived retinal sheet transplants restore higher level visual function and connectivity in the visual cortex in rat models of severe RD.

PI_NAMEs: LYON, DAVID C (contact);SEILER, MAGDALENE J

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;Address;advanced disease;Age;Age Months;Age related macular degeneration;Anatomy;Animal Model;Animals;Anterior;Area;area striata;Behavior;behavior test;blind;Blindness;Breeding;Cell Nucleus;cell type;Cells;Clinical;Collaborations;college;Complex;Conscious;Cues;Data;Disease;Dorsal;Electrocorticogram;excitatory neuron;experimental study;extrastriate visual cortex;eye regeneration;Feedback;fetal;flexibility;Frequencies;Gene Modified;gene therapy;Generations;Goals;Histologic;Human;human embryonic stem cell;human tissue;Image;image processing;immunodeficiency;Implant;improved;ineffective therapies;inhibitory neuron;Knowledge;Label;Lateral;Lead;Light;Maintenance;Medial;Methods;Microelectrodes;Midbrain structure;Modeling;Nerve;neural circuit;Neurons;neurophysiology;Operative Surgical Procedures;Organoids;Outcome;Perforation;Persons;Photoreceptors;Play;preference;Process;progenitor;rabies viral tracing;Rabies virus;Rattus;Recovery;remediation;response;Retina;retina transplantation;Retinal Degeneration;Retinal Ganglion Cells;retinal progenitor cell;retinal regeneration;Retinitis Pigmentosa;rho;Rodent;Rodent Model;sight restoration;skills;Stream;Structure;Structure of retinal pigment epithelium;superior colliculus Corpora quadrigemina;Surface;Surgeon;Synapses;Testing;Time;Tissue Donors;tissue stem cells;Tissues;Transgenic Organisms;Transplantation;Vision;Visual;Visual Cortex;visual information;Visual Pathways;visual processing;Visual System

PROJECT_TITLE: Retinal sheet transplant impact on functional organization of visual cortex in retinal degenerate animal models


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative Episodic Ataxia type 2 (EA2) and Familial hemiplegic migraine (FHM1) are neurological disorders resulting from mutations in the CACNA1A gene, which encodes the pore-forming subunit of the P/Q type calcium channel (Cav2.1). Recently, CACNA1A patients presenting primarily with cognitive defects have been described, suggesting a novel cellular mechanism may lead to their symptoms. Here we propose combining a heterologous expression system and an in vivo model system (C. elegans) to delineate the effects of CACNA1A mutations that lead primarily to cognitive symptoms on channel and synaptic function and expression.

PI_NAMEs: KURSHAN, PERI T (contact);SNELL, HEATHER DANIELLE

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Ataxia;Awareness;Behavioral;Biological Models;biophysical properties;Biophysics;Brain;Caenorhabditis elegans;Calcium Channel;cell fixing;Cell surface;Cells;Cerebellum;Characteristics;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Cognitive deficits;Complementary DNA;confocal imaging;Data;Defect;Developmental Delay Disorders;Disease;disease phenotype;Dominant-Negative Mutation;Electrophysiology (science);Embryo;Episodic ataxia;Familial Hemiplegic Migraine;Foundations;Genes;Goals;Homologous Gene;Human;Image;immunocytochemistry;Impaired cognition;in vivo;in vivo Model;Intellectual functioning disability;Kidney;Lead;Mediating;Mediator;Methods;Modeling;Molecular;Motor;motor deficit;motor disorder;mouse model;Movement Disorders;mutant mouse model;Mutate;Mutation;Nematoda;Nervous System;Nervous System Disorder;Neurobehavioral Manifestations;Neuromuscular Junction;neuronal excitability;Neurons;novel;P-Q type voltage-dependent calcium channel;Patient-Focused Outcomes;Patients;pharmacologic;Phenotype;Play;presynaptic;Presynaptic Terminals;Property;Publishing;Purkinje Cells;Q-Type Calcium Channels;Role;Structure;Surface;Symptoms;Synapses;synaptic function;Synaptic Vesicles;System;Techniques;Testing;Therapeutic Intervention;Transfection;vesicular release;voltage;Work

PROJECT_TITLE: Assessing Synaptic and Intrinsic Effects of Patient-Derived ID-Associated CACNA1A Mutations Using Multiple Models

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: MADISON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative The goal of baroreflex activation therapy (BAT) is to activate the baroreceptor afferents without activating chemoreceptor afferents or motor nerve fibers, however, selectivity between stimulation of these populations is limited in current clinical neural interface designs. In this study, we seek to determine the functional neuroanatomy responsible for the side effects of BAT and to use these data to design and test approaches for more effective BAT neural interfaces. These optimized designs will expand the therapeutic window between baroreceptor activation and limiting off-target effects.

PI_NAMEs: LUDWIG, KIP A (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adult;Affect;Anatomy;Applications Grants;Baroreflex;Biomedical Engineering;blood perfusion;Blood Pressure;Breathing;Cadaver;Cardiac;Carotid Body;carotid sinus;Cervical;Chemoreceptors;Chronic;Clinical;clinical application;Computer Models;Controlled Clinical Trials;Data;design;EFRAC;Electric Stimulation;Electrodes;engineering design;Exhibits;experimental study;Family suidae;FDA approved;Fiber;Geometry;Goals;Heart failure;Heart Rate;Histologic;Hospitalization;Human;human model;Hypertension;Image;Imaging Techniques;improved;In Situ;Larynx;Life Expectancy;Measurement;Mediating;Medical;Methods;Modeling;Motor;Motor Pathways;Muscle;Muscle Contraction;Nerve;Nerve Fibers;neural;Neural Pathways;Neuroanatomy;neuroregulation;novel;Outcome;Pathway interactions;Patients;Performance;Pharmacological Treatment;Population;porcine model;Postural adjustments;pre-clinical;Pressoreceptors;Process;Quality of life;Receptor Activation;Recurrence;Research Project Grants;Resistance;respiratory;response;Sampling;side effect;Skeletal muscle structure of neck;Source;Stretching;targeted treatment;Testing;Therapeutic;therapy design;Tissues;Translating;translational therapeutics;Treatment Efficacy;vagus nerve stimulation

PROJECT_TITLE: A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

PHR: NARRATIVE  MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer Cancer cells are characterized by altered rearrangements of chromosomal interactions with regulatory factors that contribute to expression of genes promoting tumor growth and metastasis to distal organs—the devastating end stage of breast cancer (BCa). Long non-coding RNAs (lncRNAs) are epigenetic regulators that support the genomic properties of normal and BCa cells through chromatin interactions with their target genes. We have discovered a lncRNA named MANCR that is highly expressed in metastatic BCa cells and in ER+ cells that become resistant to hormone therapy. Because inhibition of MANCR in aggressive BCa cells results in cell death, this proposal is investigating the potential for MANCR to be used as a biomarker for diagnosis in breast cancer biopsies and for therapeutic intervention in preventing primary tumor growth and tumor cells advancing to the metastatic stage. This challenging goal requires a full understanding of the mechanisms by which MANCR supports the survival of aggressive BCa cells related to MANCR-mediated regulation of chromatin interactions.

PI_NAMEs: LIAN, JANE B. (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;Address;advanced breast cancer;aggressive breast cancer;ATAC-seq;Binding Sites;Biological Markers;Biopsy;Biopsy Specimen;bone;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Cancer Prevention;breast cancer survival;Breast Cancer Treatment;Breast Epithelial Cells;cancer cell;cancer invasiveness;Cell Death;Cell Death Induction;Cell Line;Cell Proliferation;Cell Survival;Cells;Chromatin;chromatin isolation by RNA purification sequencing;Chromosomal Rearrangement;Chromosome Structures;clinical candidate;clinically significant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Coupled;CRISPR interference;CRISPR/Cas technology;Data;design;Development;Diagnosis;Distal;DNA Repair;Effectiveness;Environment;Epigenetic Process;ESR1 gene;Estradiol;Estrogen receptor positive;Estrogens;Fatty acid glycerol esters;Gene Expression;Genes;Genetic Transcription;Genome;Genome Stability;genomic locus;Genomic Segment;Genomics;Goals;Hi-C;hormone therapy;in vivo;in vivo Model;innovation;insight;Intervention;Investigation;knock-down;Literature;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Maps;MCF10A cells;MCF7 cell;MDA MB 231;Mediating;Mediator;Metastatic breast cancer;Mitosis;Mitotic;Mus;Names;Necrosis;Neoplasm Metastasis;neoplastic cell;Non-Malignant;Normal Cell;Normal tissue morphology;Oncogenic;Organ;organoid transplantation;Organoids;Outcome;overexpression;Patients;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Primary Neoplasm;Prognosis;Property;protein complex;Publishing;Regulation;Regulatory Element;Resected;Resistance;Resolution;RNA Binding;RNA purification;RUNX1 gene;Signal Transduction;Site;Spleen;Supporting Cell;Tamoxifen;Testing;Testis;Therapeutic Intervention;therapeutic target;Tissue Microarray;translational goal;Transplantation;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Promotion;Tumor Suppressor Proteins;Tumor Tissue;Untranslated RNA;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Project 3: MANCR Mediates Epigenetic Mechanisms for Survival of Advanced Breast Cancer


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Non-Hodgkin Lymphoma (NHL) will affect 2.1% of men and women during their lifetime with over 70,000 new cases diagnosed every year. This proposed research will investigate a novel immune-base therapy to treated aggressive non-Hodgkin Lymphoma. This project will investigate the basis of success and failure of this treatment and provide critical data that will optimize post-treatment surveillance strategies.

PI_NAMEs: FRANK, MATTHEW J. (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adult;Affect;Aftercare;Antigen Targeting;Antigens;appropriate dose;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;Bioinformatics;Blood;Bone Marrow Transplantation;Cancer Personalized Profiling by Deep Sequencing;Cancer Vaccines;CAR T cell therapy;career;CD19 Antigens;CD19 gene;CD22 gene;CD58 gene;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clinical Trials;Clinical Trials Design;cohort;Cytotoxic Chemotherapy;Data;density;Detection;determinants of treatment resistance;Diagnosis;Disease Resistance;Dose;Down-Regulation;Early treatment;effective therapy;Eligibility Determination;Evaluation;experience;Failure;Fine needle aspiration biopsy;Flow Cytometry;Funding;Futility;Genes;Genetic Fingerprintings;Genomic approach;genomic profiling;Genomics;Goals;High-Throughput Nucleotide Sequencing;Immune response;Immunoglobulins;Immunology;Immunotherapy;Incidence;Individual;instructor;large cell Diffuse non-Hodgkin's lymphoma;Lymphoma;Lymphoma cell;Malignant Neoplasms;men;Mentors;Mentorship;Methods;Monitor;Mutation;neoplastic cell;Non-Hodgkin's Lymphoma;novel;novel therapeutics;outcome prediction;Paper;Patients;Phase;phase I trial;Plasma;Pre-Clinical Model;predicting response;Prediction of Response to Therapy;Prognosis;programmed cell death ligand 1;Proteomics;Publishing;receptor function;Recommendation;recruit;Recurrence;Refractory;Relapse;relapse patients;Research;Resistance;response;Role;Safety;safety and feasibility;safety assessment;Site;skills;success;Surface Antigens;surveillance strategy;System;T cell response;targeted treatment;Technology;Testing;Training;Training Programs;translational research program;Treatment Failure;Treatment outcome;treatment response;tumor;tumor DNA;United States;Universities;Woman

PROJECT_TITLE: Lymphoma Antigen Density and Circulating Tumor DNA Profiling As Determinants of Novel CAR Therapies

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Primary open angle glaucoma (POAG) affects tens of millions of people around the world characterized by loss of vision as well as progressive structural and functional changes.1 Optical coherence tomography (OCT) and visual field (VF) testing are the clinical standard for measuring the structural (OCT) and functional (VF) changes associated with the development and progression of POAG.2 Combining data from these sources as well as information about patient demographics, medical history, and clinical

PI_NAMEs: CHRISTOPHER, MARK  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Affect;Age;American;Award;Blindness;career;career development;Caring;Characteristics;Clinical;Clinical Data;Data;data infrastructure;Data Set;Data Sources;deep learning;deep learning model;demographics;Detection;Development;Diagnosis;Disease;Evaluation;explainable artificial intelligence;field study;Funding;Glaucoma;Goals;Image;improved;individual patient;Infrastructure;Legal Blindness;legally blind;Measurement;Medical History;Mentors;Methods;Modeling;Monitor;multimodality;Optical Coherence Tomography;Patients;Performance;Persons;Phase;Population;Positioning Attribute;predictive modeling;preservation;Primary Open Angle Glaucoma;Progress Reports;Progressive Disease;Publications;Publishing;Qualitative Evaluations;Quantitative Evaluations;Research;Research Personnel;Research Proposals;Secure;standard measure;Techniques;tool;Training;training data;United States;Update;Vision;Visual Fields;Visualization;Work

PROJECT_TITLE: Deep Learning Approaches to Detect Glaucoma and Predict Progression from Spectral Domain Optical Coherence Tomography

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


PHR: NARRATIVE  Administration and Coordination Core Gary Stein, Core Leader; Janet Stein, Co-Leader The Administration and Coordination Core will provide scientific leadership and management, program coordination and communication, and administrative and fiscal support for the Program to maximize collaborative pursuit of epigenetic mechanisms that impact genome organization and gene expression in the context of biological control and cancer. This Core has an important role in facilitating integration of the three research projects and the shared resource core, as well as with institutional and external collaborators.

PI_NAMEs: STEIN, GARY S. (contact)

PROJECT_TERMS: Advisory Committees;Animals;Biological;Budgets;college;Committee Members;Communication;Communities;community organizations;data management;design;Documentation;Epigenetic Process;Evaluation;Gene Expression;Genome;Health;Health Benefit;Health Insurance;Health Sciences;Human;Immigration;Institution;Leadership;Logistics;Malignant Neoplasms;Manuscripts;meetings;Occupational activity of managing finances;Personnel Management;Pharmacy facility;Preparation;programs;Progress Reports;Protocols documentation;Reagent;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Schedule;Site;Specimen;Travel;Universities;Vermont

PROJECT_TITLE: Administration and Coordination Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Project Narrative: The primary mission of G-RISE at the University of Texas at El Paso is to increase the participation and retention of underrepresented minority (URM) students in biomedical research. The G-RISE program will involve the training of URM Ph.D. trainees from the Departments of Biological Sciences and Chemistry and Biochemistry. The overarching goal of this proposal is to significantly increase the participation of URM doctoral students in these Ph.D. programs over the next 5 years and successfully prepare them for careers in the research workforce using effective, evidence-informed approaches.

PI_NAMEs: AGUILERA, RENATO J (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Texas;Universities

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

PHR: NARRATIVE Experimental Integration, Design and Analysis Core The Experimental Integration, Design, and Analysis (EIDA) Core is innovatively designed to support Program Project investigations of different parameters of epigenetic control and genome organization that characterize breast cancer. The EIDA Core provides expertise in experimental design, data analysis, and laboratory support that will enhance scientific capabilities, integration, rigor and reproducibility of the Program. The Core will provide a centralized knowledge base to facilitate collaboration and data sharing to advance understanding of breast cancer biology and pathology.

PI_NAMEs: STEIN, JANET L (contact)

PROJECT_TERMS: Acceleration;Achievement;Antibodies;Area;biobank;Bioinformatics;Biological Models;Biometry;Biopsy Specimen;Cancer Biology;Cell Line;Cell model;Cells;Clinical;clinical application;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complement;Computer Analysis;Data;Data Analyses;data integration;Data Set;data sharing;data standards;Data Storage and Retrieval;design;Dimensions;Ensure;Epigenetic Process;epigenetic regulation;Experimental Designs;Faculty;Future;Generations;Genome;genome editing;genomic data;Goals;high throughput analysis;Human Resources;imaging study;Individual;Informatics;innovation;insight;Investigation;knowledge base;Laboratories;Libraries;Malignant Breast Neoplasm;Methods;Molecular;next generation sequencing;novel;Organoids;Output;Pathology;Patients;Positioning Attribute;Procedures;programs;Property;Protocols documentation;public database;Quality Control;Reagent;reagent standardization;Reproducibility;Research;Research Personnel;Resources;Sampling;Services;Source;Standardization;synergism;Technology;Testing;Tissue Microarray;Tissues;Translating;translational applications;treatment response;Tumor Tissue;Validation;Work


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative This study will combine eight data sources on lifecourse social and vascular risk factors for Alzheimer’s Disease and Related Dementias (ADRD) to create a large (N=304,171) and diverse (25% Black) synthetic birth cohort (age 0 to 90) for research on ADRD. We will apply rigorous methods to estimate and incorporate corrections for selection forces, including survival, enrollment, attrition, and reverse causation from incipient dementia to risk factor changes. The synthetic cohort will then be used to rigorously estimate how lifecourse social and vascular factors and hypothetical age-specific interventions on those risk factors would affect ADRD risk and ADRD disparities.

PI_NAMEs: GLYMOUR, MEDELLENA MARIA;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adolescent;Adopted;Adult;Affect;African American population;Age;age related;Aging;Alzheimer's disease related dementia;Alzheimer's disease risk;Attenuated;biological sex;Birth;Black American;Black Populations;Black race;Blood Vessels;Body Weight decreased;caucasian American;Child;Childhood;cohort;Cohort Studies;Coronary artery;cost;Data;Data Collection;Data Set;Data Sources;Dedications;Dementia;dementia burden;dementia risk;Development;Diagnosis;Disparity;emerging adult;Enrollment;Etiology;Evaluation;Face;Genetic Risk;geographic disparity;Goals;Health;Health and Retirement Study;Heart;high risk;human old age (65+);Impaired cognition;improved;Individual;Intervention;late life;Lead;Life;Life Cycle Stages;Longitudinal Studies;men;Mendelian randomization;Methodology;Methods;middle age;Modeling;multiple data sources;National Health and Nutrition Examination Survey;National Longitudinal Survey of Adolescent to Adult Health;National Longitudinal Survey of Youth;nutrition;Obesity;older adult;Pattern;Phase;Positioning Attribute;prevent;Prevention;Process;protective factors;Public Health;racial disparity;Research;research study;Risk;Risk Factors;Role;Sampling;social;social factors;socioeconomic disadvantage;Socioeconomic Factors;Stroke;Structure;Time;tool;vascular factor;vascular risk factor;Walking;Woman;young adult

PROJECT_TITLE: Building an unbiased pooled cohort for the study of lifecourse social and vascular determinants of Alzheimer's Disease and Related Disorders

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Novel functional cell models will be established from normal prostate and different stages of prostate cancer from African American (AA) and European American (EA) men. Biological and genetic analysis of these cultures will be correlated with corresponding xenografts and annotated genomic and patient clinical information. Overall our studies will provide a new and invaluable resource for evaluating the known health disparities of prostate cancer in these patient populations.

PI_NAMEs: LIU, XUEFENG  (contact)

PROGRAM_OFFICER_NAME: KAI, MIHOKO

PROJECT_TERMS: Abnormal Karyotype;advanced prostate cancer;African American;African ancestry;American;Anchorage-Independent Growth;androgen independent prostate cancer;androgen sensitive;Androgens;Behavior;biobank;Biological;Biological Assay;Biological Process;c-myc Genes;Cancer Biology;cancer diagnosis;Cancer Etiology;cancer initiation;Cancer Model;Cancer Patient;carcinogenesis;Caring;CDK4 gene;Cell Culture Techniques;Cell Line;Cell model;Cell Reprogramming;cell transformation;Cells;Cessation of life;Chemoresistance;Clinical;Data;Death Rate;Diagnosis;Disparity;Economics;Education;Environment;Epigenetic Process;Epithelial Cells;Epithelium;ethnic difference;Ethnic Origin;European;Exhibits;exome sequencing;Fibroblasts;Genes;Genetic;genetic analysis;Genomics;Goals;health disparity;Human;In Vitro;in vivo;Incidence;Invaded;Laboratories;male;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;men;metaplastic cell transformation;Methods;migration;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutation;Nature;Neoplasm Circulating Cells;Neuroendocrine Prostate Cancer;novel;novel strategies;Oncogenes;Organoids;outcome disparities;Pathway interactions;patient population;Patients;Phase;Phenotype;Play;Population;Predisposition;Prevention strategy;Property;Prostate;prostate cancer cell;prostate cancer progression;prostate cancer risk;Prostatic Neoplasms;Protocols documentation;Public Health;Race;racial difference;Refractory;Research;Resistance;Resources;response;Role;SCID Mice;screening;social;success;Technology;Testosterone;Therapeutic Intervention;tool;transcriptome;transdifferentiation;treatment strategy;tumor;tumor progression;Tumor-Derived;United States;Work;Xenograft procedure

PROJECT_TITLE: Developing Functional Human Cell Models to Study Initiation and Progression of Prostate Cancer between AA and EA men

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Precision Medicine;Stroke

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE/ RELEVANCE TO PUBLIC HEALTH STATEMENT This multicenter study of Platelet Expression of FcγRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis advances recent data on blood flow changes in brain arteries that cause repeated injury and disability. New approaches to blood samples and imaging of mechanical forces around narrowed arteries are used to predict new strokes and silent brain damage over the course of 1 year. The research has direct implications for enhancing precision medicine of stroke, targeting the devastating consequences of the most common cause of stroke and leading cause of disability with vast disparities around the world.

PI_NAMEs: LIEBESKIND, DAVID SIGMUND (contact);SCHNEIDER, DAVID J

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: 3-Dimensional;Accounting;Acute;Address;adjudication;Age;Agonist;Angiography;Architecture;Arteries;Biological;Biological Assay;Biology;Blood flow;Blood Platelets;Blood specimen;Brain;Brain Injuries;brain magnetic resonance imaging;Cardiovascular system;Cerebral Ischemia;cerebrovascular;Clinical;clinical translation;Collaborations;comorbidity;Core Facility;Coronary Arteriosclerosis;Coronary Circulation;Data;data management;Diagnostic;disability;disease diagnosis;Disparity;Distal;Eligibility Determination;Enrollment;ethnic diversity;Ethnic Origin;Event;Exposure to;Functional disorder;Geography;Goals;hemodynamics;Heterogeneity;Hour;Hypertension;Image;Incidence;indexing;Individual;Individual Differences;individualized medicine;Injury;Intracranial Atherosclerotic Disease;Ischemia;ischemic injury;Ischemic Stroke;Liquid substance;Magnetic Resonance Imaging;Measurement;mechanical force;Minor;Modeling;Multicenter Studies;neurovascular;novel;novel strategies;Observational Study;Outcome;Participant;Pathology;Patients;Pattern;Pharmaceutical Preparations;Platelet Activation;Platelet aggregation;Platelet Aggregation Induction;Population Heterogeneity;post stroke;precision medicine;prevent;Productivity;Public Health;Race;racial diversity;Recording of previous events;recruit;Recurrence;Research;Research Infrastructure;response;Risk;Risk Factors;Role;Serial Magnetic Resonance Imaging;sex;shear stress;Site;Statistical Models;statistics;Stenosis;Stimulus;Stratification;Stroke;Stroke prevention;stroke risk;stroke therapy;Symptoms;synergism;Thrombosis;Transient Ischemic Attack;Universities;Vermont;Work

PROJECT_TITLE: Platelet Expression of FcgammaRIIa and Arterial Hemodynamics to Predict Recurrent Stroke in Intracranial Atherosclerosis

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Project Narrative The proposed research will determine the underlying mechanism(s) for increased cancer risk in individuals with the Ashkenazi-specific p53 hypomorph G334R, using human LCLs and CRISPR knock-in lines as well as a novel mouse model. It will also analyze common activities between three different p53 hypomorphs, and it will test the hypothesis that we can create a gene-signature that is prognostic for other hypomorphs: as such, this research can be used to more accurately predict cancer risk in hundreds of thousands of families in the United States with germline variants in p53.

PI_NAMEs: MURPHY, MAUREEN E. (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Adopted;Adrenal Gland Neoplasms;Affect;Age;Alleles;American;anti-cancer research;Apoptosis;Arginine;Benign;Binding;Biology;Breast Cancer Cell;Breast Cancer Model;breast cancer progression;Cancer Biology;cancer risk;Cell Line;Cells;chemotherapy;Childhood;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;cytotoxicity;Data;Defect;Diagnostic;Disease;DNA;Doctor of Philosophy;Family;gain of function;Generations;Genes;Genetic;genetic signature;Genetic Transcription;genetic variant;Germ-Line Mutation;Glutaminase;Glycine;Goals;HCT116 Cells;Human;Impairment;improved;Incidence;Individual;Inherited;inhibitor;Knock-in;Li-Fraumeni Syndrome;Life;Loss of Heterozygosity;lymphoblastoid cell line;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;medical schools;Molecular Conformation;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;NF-kappa B;novel;novel therapeutics;Oncogenic;Patients;Penetrance;Pennsylvania;Peripheral Blood Mononuclear Cell;personalized therapeutic;Persons;Pharmaceutical Preparations;Philadelphia;Prognosis;prognostic;Proteins;Reagent;Research;Risk;RNA;senescence;Siblings;Testing;The Wistar Institute;Therapeutic;TP53 gene;Transactivation;transcriptome sequencing;tumor;Tumor Suppression;Tumor Suppressor Proteins;United States;Universities;University Hospitals;Variant

PROJECT_TITLE: The genetics of tumor suppression by p53

STUDY_SECTION: CCB

STUDY_SECTION_NAME: Cancer Cell Biology Study Section[CCB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Precision Medicine

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative The proposed study uses novel, advanced imaging techniques (i.e. individual-specific Precision Functional Mapping of resting state functional connectivity MRI), along with new computational tools (i.e. Functional Random Forest) to identify atypical brain physiologies related to negative valence symptoms in trans- diagnostic fashion across ADHD, Autism and typical development. This work will utilize new methods to identify brain biomarkers related to important outcomes of interest (i.e. negative valence symptoms) independent of diagnostic category. The findings from this study will advance our knowledge of the neurobiological underpinnings of negative valence symptomatology, ADHD and Autism, and assist in the improved characterization of homogeneous subtypes for future genetic, functional, and therapeutic investigations.

PI_NAMEs: DOSENBACH, NICO ;FAIR, DAMIEN A (contact)

PROGRAM_OFFICER_NAME: PACHECO, JENNIFER LYNN

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Algorithms;Amygdaloid structure;Anger;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral;behavioral study;Biological Markers;Brain;brain behavior;Categories;Child;Child Psychiatry;Childhood;Clinical;clinical care;clinical heterogeneity;clinical practice;cognitive control;cognitive development;cohort;Communities;Complement;Complex;Computational Science;computerized tools;cost;Data;Data Set;design;Detection;Development;Diagnosis;Diagnostic;Dimensions;Disease;disorder subtype;Etiology;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Future;Genetic;Graph;gray matter;Heterogeneity;Hybrids;Imaging Techniques;improved;Individual;Individual Differences;individual patient;innovation;interest;Investigation;Knowledge;Machine Learning;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Mental disorders;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Motion;Movement;Myelin;National Institute of Mental Health;Nature;Negative Valence;network architecture;Neurobiology;Neurodevelopmental Disorder;neuroimaging;next generation;novel;Outcome;Output;parent grant;Participant;Patients;Pediatrics;personalized diagnostics;Phenotype;Physiology;Population;Prevention;Procedures;Psychiatry;Psychopathology;Publishing;random forest;Research;Research Domain Criteria;Research Personnel;Rest;Retinal blind spot;Sample Size;Sampling;Scanning;Signal Transduction;Site;Specificity;symptomatology;Symptoms;System;Testing;Therapeutic;Time;Translating;Translations;treatment stratification;treatment trial;unsupervised learning;Variant;Work;Youth

PROJECT_TITLE: Identification of outcome-based sub-populations using deep phenotyping and precision functional mapping across ADHD and ASD

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: Project Narrative This training grant supports predoctoral trainees in the Immunology Training Program of Mayo Graduate School, providing students with the requisite research and leadership skills to become heads of research laboratories and leaders in the biomedical sciences. Understanding how the immune system functions and its role in disease pathogenesis is critical to developing novel approaches to cure disease. The young scientists supported by this training grant will become the next generation of innovators to develop new therapies for immune-related disease.

PI_NAMEs: SHAPIRO, VIRGINIA SMITH (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Immunology;Training Programs

PROJECT_TITLE: Training Program in Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Successful completion of this proposed study will help elucidate new signal transduction pathways that are important for red cell development. Understanding how these pathways function may lead to the development of novel strategies for the treatment of red-cell related diseases and production of red blood cells for transfusion medicine.

PI_NAMEs: JI, PENG  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Acetylation;Actins;Affect;Anemia;Biochemical;Biological Assay;Biology;Cell Cycle;Cell Nucleus;Cells;Cytokinesis;Cytoplasmic Protein;Data;Deacetylase;Deacetylation;Defect;Development;Disease;Electron Transport Complex III;Enzymes;Erythroblasts;Erythrocyte Transfusion;Erythrocytes;Erythroid;Erythroid Cells;Erythropoiesis;Functional disorder;Generations;genetic technology;Genetic Transcription;Goals;HDAC6 gene;Hematopoietic;Image;In Vitro;in vivo;insight;Knockout Mice;Lysine;Mass Spectrum Analysis;Mediating;Mediator;Membrane;Microfilaments;Microscopy;Mitosis;Modification;Motility;mouse model;Mus;mutant;non-histone protein;novel;novel strategies;Organelles;overexpression;Pathway interactions;Phosphorylation;Play;polymerization;Polymers;Post-Translational Protein Processing;Process;Production;Proliferating;protein complex;Protein Family;Publishing;Regulation;Reporting;Reticulocytes;Rho-associated kinase;Role;Serum Response Factor;Signal Transduction;Signal Transduction Pathway;Spectrin;Techniques;Transcriptional Regulation;transfusion medicine;Transplantation;treatment strategy;Work

PROJECT_TITLE: The roles of mDia2 in membrane remodeling and organelle clearance during reticulocyte formation

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics;Immunotherapy;Precision Medicine;Prevention;Skin Cancer

PHR: PROJECT NARRATIVE Patients with stage II-III melanoma have an uncertain prognosis, with ~50% mortality due to tumor recurrence, emphasizing the need for biomarkers to stratify patients for clinical trials of adjuvant therapies. In this UH2-UH3 proposal, we will analytically and clinically validate a previously discovered immune gene signature biomarker(s) for prognostic application in patients with stage II-III melanoma.

PI_NAMEs: SAENGER, YVONNE MARGARET (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Adjuvant;Adjuvant Study;Adjuvant Therapy;Algorithmic Analysis;autoimmune toxicity;Binding;Biological Assay;Biological Markers;biomarker development;biomarker signature;Biopsy;Biotechnology;British Columbia;Cd68;CD8B1 gene;Cessation of life;CLIA certified;Clinical;clinical application;clinical diagnostics;clinical practice;clinical prognostic;Clinical Trials;cohort;Collaborations;Comprehensive Cancer Center;Data;Data Set;density;Diagnosis;Eastern Cooperative Oncology Group;Ensure;Environment;Excision;experimental study;Exposure to;Face;follow-up;Formalin;Future;Genes;Genetic Markers;genetic signature;Goals;health care settings;Herbert Irving Comprehensive Cancer Center;high risk;Immune;immune activation;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunologic Markers;Immunology procedure;Immunotherapy;immunotherapy clinical trials;Impairment;improved;indexing;Infiltration;instrumentation;Interferons;Interobserver Variability;Investments;Laboratories;Manuals;Melanoma;Melanoma patient;Messenger RNA;Methodology;Methods;Migration Assay;Morphology;mortality;nano-string;New York;Operative Surgical Procedures;Outcome;Paraffin Embedding;Pathologic;patient biomarkers;patient population;Patient Selection;patient stratification;Patients;Phase;Pilot Projects;Placebos;Polymerase Chain Reaction;Population;predicting response;prevent;Procedures;Process;Prognosis;prognostic;Prognostic Marker;prognostic value;Program Evaluation;prospective;Publishing;Randomized;Recurrence;Recurrent tumor;Regulator Genes;relapse prevention;Reporter;Reproducibility;Research;Resected;Retrospective Studies;Risk;Risk Assessment;RNA;Roswell Park Cancer Institute;sample fixation;Sampling;Specificity;Specimen;Staging;System;Technology;Testing;Time;Tissue Embedding;Tissues;tool;Training;transcriptome sequencing;trial design;tumor;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Universities;Validation

PROJECT_TITLE: A prognostic mRNA immune signature for resected stage II-III melanoma


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Immunization;Immunotherapy;Infectious Diseases;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

PHR: PROJECT NARRATIVE Herpes simplex virus 1 (HSV-1) is the leading cause of infectious blindness in the Western world. The objective of the proposed research, which uses a unique HLA transgenic rabbit model of HSV-1 spontaneous reactivation, is to develop an innovative tissue-targeted vaccine designed to bolster the number of functional TG-resident CD8+ TRM cells to reduce virus reactivation from latently infected TG, reducing virus shedding in tears, thus preventing potentiall y blinding recurrent ocular herpetic disease.

PI_NAMEs: BENMOHAMED, LBACHIR  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: adeno-associated viral vector;Afferent Neurons;Blindness;booster vaccine;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;chemokine;Combined Vaccines;Cornea;CXCL11 gene;CXCR3 gene;cytokine;Data;Dependovirus;Engineering;Epitopes;exhaust;exhaustion;Eye Infections;Eyedrops;FDA approved;Frequencies;Funding;genome-wide;Goals;Grant;Herpes Simplex Infections;Herpesviridae Infections;Herpesvirus 1;Herpetic Keratitis;HLA A*0201 antigen;Homing;immune checkpoint;immune checkpoint blockade;Immunization;Immunodominant Epitopes;Immunotherapeutic agent;Individual;Infection;innovation;Interleukin-15;interleukin-15 receptor;Interleukin-2;Intramuscular;Intravenous;Knowledge;Lead;Ligands;Longevity;man;Maps;Memory;Modeling;Monoclonal Antibodies;multidisciplinary;Neurons;neurotropic;Oryctolagus cuniculus;Pathway interactions;Patients;PD-1 blockade;PD-1 pathway;Persons;Phenotype;Positioning Attribute;prevent;Primary Infection;programmed cell death protein 1;promoter;prototype;Publishing;reactivation from latency;receptor;Recurrence;Research;Research Personnel;Residencies;RNA vaccine;Role;Satellite Viruses;Simplexvirus;single-cell RNA sequencing;Structure of trigeminal ganglion;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Therapeutic;therapeutic vaccine;therapeutically effective;Tissues;Topical application;transcriptome;Transgenic Organisms;Translational Research;United States;vaccine candidate;Vaccine Design;Vaccine Production;Vaccines;vector;vector-based vaccine;Viral;Virus;Virus Shedding;Western World;Work

PROJECT_TITLE: Developing A Tissue-Targeted Ocular HSV Therapeutic Vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Genetics;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases;Tuberculosis

PHR: Narrative Mycobacterium tuberculosis, the causative agent of tuberculosis disease, remains a global public health challenge, and development of new interventions and identification of drug resistance are among the objectives of the World Health Organization End TB Strategy. Leveraging on the success of the TM4 mycobacteriophage and the sensitivity of the nanoluciferase reporter enzyme, the proposed work will offer a rapid, cost-effect phenotypic reference method drug susceptibility testing of M. tuberculosis.

PI_NAMEs: O'DONNELL, MAX  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Antibiotic susceptibility;Antimycobacterial Agents;Bacteriophages;Biological Assay;Biological Markers;Clinical;Clinical Trials;Collection;community transmission;Complement;Complex;cost;Data;Detection;detection limit;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic development;Disease;DNA cassette;drug development;drug repurposing;Drug resistance;Drug resistance in tuberculosis;Drug resistant Mycobacteria Tuberculosis;drug testing;Early identification;Ensure;Enzymes;Fluorescence;Funding;Gene Modified;Genetic;genome sequencing;Genotype;Genus Mycobacterium;Grant;Growth;Health system;improved;Income;Infection;instrument;Intermediate resistance;International;Intervention;Laboratories;Libraries;Linezolid;luminescence;Measurement;Measures;Mediating;Methods;Minimum Inhibitory Concentration measurement;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Mycobacteriophages;Mycobacterium tuberculosis;Mycobacterium tuberculosis complex;nanoluciferase;New York;Newly Diagnosed;next generation;novel;novel therapeutics;Oral;Outcome;Patients;Persons;phage vector;Pharmaceutical Preparations;Phenotype;phenotypic data;point of care;Prediction of Response to Therapy;Predisposition;preservation;prevent;Process;programs;Prospective, cohort study;Public Health;Publishing;rapid detection;Reader;recruit;Regimen;Reporter;Research;Resistance;Rifampicin resistance;Rifampin;Sampling;Site;South Africa;South African;Sputum;success;System;Techniques;Testing;Time;Treatment outcome;Treatment Protocols;treatment response;Tuberculosis;Tuberculosis diagnosis;tuberculosis drugs;tuberculosis treatment;Validation;Virulent;Virus;whole genome;Work;World Health Organization

PROJECT_TITLE: Rapid phenotypic detection of complex and emergent TB drug-resistance using a next-generation nanoluciferase reporter phage


NIH_SPENDING_CATS: Behavioral and Social Science

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: The goal of the proposed U-RISE program at the City College of New York is to further increase the number of qualified undergraduates from underrepresented groups who continue their education at the Ph.D. level in the biomedical and behavioral sciences. This will enhance public health by increasing the pool of biomedical scientists working to study the underlying bases of biological phenomena and diseases.

PI_NAMEs: LEVITT, JONATHAN B (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic Medical Centers;Address;Admission activity;Advisory Committees;atmospheric sciences;Behavioral Sciences;Biochemistry;Biology;Biomedical Engineering;Cancer Center;Chemistry;Cities;college;community college;Coupled;Development;Doctor of Philosophy;Earth science;Education;Educational workshop;experience;Faculty;faculty mentor;Goals;graduate school preparation;Institution;Laboratories;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;New York;New York City;Outcome;peer;Physics;programs;Psychology;Publications;Qualifying;recruit;Research;Research Training;Schools;Science;scientific atmosphere;Scientist;Self Perception;structural biology;Student recruitment;student training;Students;symposium;System;Training;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;Universities;Work

PROJECT_TITLE: U-RISE at City College of New York


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: RENO

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Neuronal axons are essential for proper brain wiring and travel long distance from the cell body, which necessitates localized protein synthesis in axons. Although dysfunctional axonal protein synthesis is linked to multiple brain disorders, our understanding of the molecular mechanisms underlying the local protein synthesis in axons is largely limited. This proposal aims to elucidate how axonal protein synthesis is regulated at the molecular level, which will provide essential basic knowledge for developing effective treatment for the brain disorders that are caused by dysregulated axonal protein synthesis.

PI_NAMEs: KIM, JUNG HWAN  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: 3' Untranslated Regions;Amino Acids;Axon;Binding;Binding Sites;Biological Models;Biological Process;Brain;Brain Diseases;Cell Adhesion Molecules;Cells;CPE-binding protein;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Dendrites;derepression;Disease;Down Syndrome Cell Adhesion Molecule;Drosophila genus;effective therapy;Event;gain of function;Genetic;Goals;in vivo;innovation;insight;Knowledge;Length;Leucine Zippers;Link;long term memory;loss of function;Maps;Mediating;Messenger RNA;mimetics;Modeling;Molecular;mRNA Translation;mutant;Nervous System;Nervous System Physiology;Neurobiology;Neurons;novel;Oocytes;Outcome;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Play;Poly(A) Tail;polyadenylase;Polyadenylation;Protein Biosynthesis;protein expression;Proteins;Regulation;Research;Role;Signal Transduction;Synapses;System;Testing;tool;Translational Derepression;Translations;Travel;Untranslated Regions

PROJECT_TITLE: Mechanisms of Local Protein Synthesis in Axon Arborization

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: INDIANAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative  The proposed research in this application is highly relevant to public health because better understanding of the molecular pathogenesis of alcohol-related liver disease is expected to provide potential novel drug targets for the prevention and treatment of this common liver disorder. Specifically, the proposed research in this application will address the underpinning for the strong association of the human PNPLA3 gene with the alcohol-related liver disease. Thus, this project is highly relevant to the part of NIH’s mission that pertains to pursuing fundamental knowledge that will help extend healthy life and reduce the burdens of illness.

PI_NAMEs: DONG, X. CHARLIE (contact)

PROGRAM_OFFICER_NAME: MURRAY, GARY

PROJECT_TERMS: Address;Alcohol consumption;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcohols;Amino Acids;Animal Model;Biochemical;burden of illness;Cell Culture Techniques;Cell Death Induction;Cell model;Cirrhosis;common treatment;Data;Development;Disease;expectation;Fatty Liver;Fibrosis;Functional disorder;Future;gain of function;Genes;genetic variant;genome wide association study;Health;Hepatic;Hepatic Fibrogenesis;Hepatic Stellate Cell;Hepatitis;high risk;Human;Hydrolase;In Vitro;in vivo;Individual;Infiltration;innovation;insight;Investigation;Isoleucine;Knowledge;Kupffer Cells;Life;Lipase;Lipids;Liver;Liver diseases;Liver Fibrosis;liver inflammation;loss of function;Macrophage;Mediating;Mediation;Metabolism;Methionine;migration;Mission;Molecular;mouse model;mutant;Mutation;new therapeutic target;NF-kappa B;novel;Pathogenesis;Pathology;Pathway interactions;Patients;Phenocopy;Phospholipase;Play;Predisposition;Prevention;Primary carcinoma of the liver cells;Process;Proliferating;Proteins;Public Health;Regulation;Reproducibility;Research;response;retinyl palmitate;risk variant;Role;Signal Pathway;Single Nucleotide Polymorphism;Source;therapeutic development;TNF gene;Transforming Growth Factor beta;Transgenic Mice;United States National Institutes of Health;Validation;Variant

PROJECT_TITLE: The pathophysiological function of PNPLA3-148M variant in alcohol-induced liver injury

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Kidney Disease;Nutrition;Obesity;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Immune checkpoint blockade (ICB) has revolutionized cancer treatment but many patients fail to respond to even the most promising immunotherapies. Thus, there persists an urgent need to identify the host factors responsible for the limited efficacy of these otherwise potent immunotherapies in cancer patients. Our study will focus on evaluating contributions of obesity- associated IL-1b as an apex regulator of ICB outcomes in renal cancer, with the goal of obtaining knowledge that will improve treatment outcomes for RCC patients and ultimately save lives.

PI_NAMEs: NORIAN, LYSE A (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Adult;Advanced Malignant Neoplasm;antagonist;anti-PD-1;Apical;Area;Biological;Biological Response Modifiers;Body mass index;cancer care;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;cancer type;CCL2 gene;cell type;chemokine;Chemotactic Factors;Clinical Management;Clinical Research;cohort;Combination immunotherapy;comorbidity;comparative efficacy;CXCL1 gene;CXCL10 gene;cytokine;Data;Development;Disease;Disease Progression;Disparate;effector T cell;Exhibits;fighting;Frequencies;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Healthcare;human subject;immune checkpoint blockade;Immune system;Immunooncology;Immunosuppression;Immunotherapy;improved;Infiltration;Inflammation;Integration Host Factors;Interdisciplinary Study;Interleukin-1;Kidney Neoplasms;Knowledge;Link;Mediating;Modeling;Mus;Myelogenous;Myeloid-derived suppressor cells;nanoparticle;novel;novel therapeutic intervention;novel therapeutics;Obese Mice;obese patients;Obesity;Outcome;Overweight;Patient-Focused Outcomes;Patients;Pattern;pre-clinical;Pre-Clinical Model;preclinical study;Predisposing Factor;Predisposition;Prevalence;prospective;Publications;RANTES;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research;Research Personnel;Resistance;response;Slide;Solid Neoplasm;standard of care;Study Subject;T-Lymphocyte;Testing;Therapeutic;Thinness;Time;Treatment outcome;trend;tumor;tumor DNA;Tumor Immunity;tumor microenvironment;tumor progression;tumorigenic;X-Ray Computed Tomography

PROJECT_TITLE: Overcoming obesity-associated immunotherapy resistance in renal cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: This research will help us identify differences and similarities in how social reward versus non-social rewards are processed and how the various dimensions of social reward are represented in the brain. Findings from this study will ultimately aid in the development of better therapeutic options to help patients with social behavioral deficits, such as autism spectrum disorder.

PI_NAMEs: MURUGAN, MALAVIKA  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Address;adult with autism spectrum disorder;Amygdaloid structure;Animals;autism spectrum disorder;autistic children;Automobile Driving;Behavior;Behavioral;Behavioral Paradigm;Biological Assay;Brain;Color;Communities;Development;Diagnosis;Dimensions;Disease;Food;Friends;Glutamates;Health;Human;human subject;Image;imaging modality;Imaging Techniques;Individual;Interneurons;Knowledge;Life;Loneliness;Mammals;Maps;Medial;Mediating;member;Microscope;Motivation;Mus;neural;neural circuit;neural correlate;Neurons;novel;Nucleus Accumbens;optogenetics;Oxytocin;Patients;Persons;Play;Population;Population Projection;Positive Reinforcer;Prefrontal Cortex;Process;Research;Resolution;response;reward circuitry;reward processing;Rewards;Role;Route;Shapes;social;Social Behavior;social deficits;Social Interaction;Stimulus;Sucrose;Testing;Therapeutic;Thirst;Ventral Tegmental Area;Visit;Water

PROJECT_TITLE: Prefrontal circuits in processing social versus non-social rewards

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lymphatic Research;Prevention;Rare Diseases;Tuberous Sclerosis;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative This UO1 brings together a unique team of leaders in lymphangioleiomyomatosis (LAM) and tuberous sclerosis complex (TSC) to address key unanswered questions with high clinical impact. First, how can factors secreted by LAM cells, identified through analysis of the LAM “secretome” and single cell RNA-sequencing, be used therapeutically and in the development of models of disease progression? Second, what are potential Rapamycin-insensitive pathways leading to LAM cell survival? Third, are there genetic factors associated with the risk of disease progression, including both novel disease modifiers and somatic genetic mosaicism for TSC gene mutations?

PI_NAMEs: HENSKE, ELIZABETH P (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Address;Alleles;Alveolar Cell;alveolar destruction;analog;Angiomyolipoma;apoAI regulatory protein-1;Autophagocytosis;Award;Biogenesis;Biological Markers;Blood;celecoxib;Cell Death;cell growth;Cell Survival;Cells;Chronic;Clinical;clinical center;clinical phenotype;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Cyst;Data;Data Set;Development;Diagnostic;diagnostic biomarker;Disease;disease model;Disease Progression;disorder risk;Doctor of Philosophy;dosage;early detection biomarkers;Early identification;Extramural Activities;Fibroblasts;FRAP1 gene;Gene Mutation;Genes;Genetic;genetic analysis;genome sequencing;genome wide association study;Goals;high risk;Human;human RNA sequencing;Immunocompetent;In Vitro;in vivo Model;Interleukin-6;Intramural Research Program;Longitudinal Studies;Loss of Heterozygosity;Lung;Lung Lymphangioleiomyomatosis;Lymphangiogenesis;Lymphangioleiomyomatosis;Manuscripts;member;Metabolism;MicroRNAs;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mosaicism;Mosses;mouse model;Mus;Mutation;New Agents;Nodule;novel;novel marker;novel therapeutic intervention;participant enrollment;Pathogenesis;Pathway interactions;Patients;Pattern;Peer Review;personalized care;personalized medicine;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Pleural effusion disorder;Preparation;Prevalence Study;Prognostic Marker;programs;progression risk;protein complex;Protein Secretion;Protocols documentation;Publishing;pulmonary function;pulmonary function decline;recruit;Renal Angiomyolipoma;Research;research study;Resources;response;Risk;Safety;sensor;Serum;Severities;single-cell RNA sequencing;Sirolimus;System;Testing;Therapeutic;therapeutic target;Therapeutic Uses;Toxic effect;TSC2 gene;Tuberous Sclerosis;Tuberous sclerosis protein complex;tumor;tumor-immune system interactions;United States National Institutes of Health;Vascular Endothelial Growth Factor D;whole genome;Woman;Women's study;Work

PROJECT_TITLE: The Molecular and Genetic Pathogenesis of LAM


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Public Health Relevance: HIV Associated Neurocognitive Disorder (HAND) is one of the most common and clinically important complications of patients living with HIV infection. Unfortunately, the progression of HAND is known to be worsened by drugs such as cocaine. We will explore the role of a novel metabolic intermediate, itaconate, in modulating the immune response to neuroinflammation in the presence of HAND and cocaine.Brain- penetrant itaconate esters with translational therapeutic potential will be employed to resolve neuroinflammation.

PI_NAMEs: BOOZE, ROSEMARIE M;FRIZZELL, NORMA ;SHTUTMAN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: Aconitic Acid;activating transcription factor 3;Animal Model;Anti-Inflammatory Agents;Arthritis;Attenuated;attenuation;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;brain tissue;Carboxy-Lyases;Cell Death;Cells;Cessation of life;Clinical;clinically relevant;Cocaine;cocaine exposure;Cocaine use disorder;cytokine;Data;Development;Disease;drug of abuse;Esters;Fumarates;Functional disorder;Funding;Genes;HIV;HIV Infections;HIV-associated neurocognitive disorder;Immune;Immune response;immunoregulation;Impaired cognition;Individual;Infection;Inflammasome;Inflammation;Inflammatory;innovation;Lipopolysaccharides;Macrophage;Metabolic;Microglia;Modeling;mouse model;Mus;National Institute of Drug Abuse;Neurocognitive;neuroinflammation;Neurons;novel;novel strategies;novel therapeutics;overexpression;Pathway interactions;Patients;Penetration;Peripheral;Persons;Pharmaceutical Preparations;Post-Translational Protein Processing;Production;programs;Proteins;Proteomics;Psoriasis;public health relevance;Regulation;Research;response;Rodent;Role;Severities;Shock;Study models;suicidal;Suicide;Testing;Therapeutic;therapeutically effective;Toxic effect;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;translational therapeutics;Treatment Efficacy;Tricarboxylic Acids;Up-Regulation;Work;World Health Organization

PROJECT_TITLE: Targeting Immunometabolism: a novel role for itaconate in the treatment of HIV-associated neurocognitive disorder and cocaine use disorder

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Immunization;Infectious Diseases;Nutrition;Pediatric;Prevention;Vaccine Related

ORG_CITY: KARACHI

ORG_COUNTRY: PAKISTAN

ORG_FIPS: PK

ORG_NAME: AGA KHAN UNIVERSITY (PAKISTAN)

PHR: Project Narrative This D43 International Research Training Grant award will: a) Build a training program at the Aga Khan University (AKU), Pakistan; 2) Develop research capacity in infectious and gastrointestinal disease; 3) Emphasize three areas of critical importance to child survival in Pakistan; undernutrition as an enteric infectious disease (i.e., Environmental Enteric Dysfunction – EED), vaccine efficacy, and understanding and reversing the vicious association of the cycle between maternal-child undernutrition and infectious diseases. This work will be executed in collaboration with colleagues from the University of Virginia (UVa). Through this proposal, we aim to produce a cadre of high quality, independent local scientists and build sustainable capacity in pediatric infectious disease and gastroenterology and nutrition research, specifically related to EED and its complications such as vaccine failure, undernutrition and subsequent growth failure in children residing in Pakistan.

PI_NAMEs: ALI, SYED ASAD  (contact);MOORE, SEAN RYAN

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acute-Phase Reaction;Address;Area;Bioethics;Biometry;burden of illness;Child;Childhood;Chronic;Clinical Markers;Clinical Nutrition;Clinical Research;Communicable Diseases;Country;Data Science;Development;Disease;Doctor of Philosophy;Educational workshop;empowerment;Enteral;enteric pathogen;Epidemiology;Exposure to;Failure;Foundations;Functional disorder;Gastroenterology;Goals;Grant;Growth;Health;Immunologic Stimulation;Immunologics;Immunology;Impairment;Infectious Diseases Research;Inflammation;Laboratories;low and middle-income countries;Malnutrition;Mucous Membrane;neglect;Neurocognitive;nutrition;Nutritional Study;Oral;Organoids;Pakistan;Pathway interactions;programs;Research;Research Personnel;Research Project Grants;Research Training;Scientist;Series;Short-Term Course;skills;Small Intestines;socioeconomics;Training;Training Programs;Underweight;Universities;vaccine failure;vaccine immunogenicity;Virginia;wasting

PROJECT_TITLE: Pediatric Infectious Diseases, Enteric Health and Malnutrition in Pakistan (PIDEMP) Research Training Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Z(55)R]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Genetics;Osteoarthritis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Osteoarthritis (OA), the most common joint disease, leads to severe pain and disability primarily due to altered chondrocyte mechanotransduction and increased joint inflammation. Exome-sequencing studies have identified a mutation that increases risk of developing early on-set OA in COL6A3, a critical component of the chondrocyte’s pericellular matrix (PCM). While it is likely that the effects of this mutation are due to changes in the properties of the PCM, the etiopathogenesis remains unknown. This project will determine the mechanistic link between COL6A3 mutation and OA by investigating how this mutation affects the PCM’s susceptibility to inflammation-induced degradation and chondrocyte catabolism, along with determining alterations in chondrocyte mechanotransduction.

PI_NAMEs: HARISSA, ZAINAB  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Area;arthropathies;Atomic Force Microscopy;Biochemical;Biological;Biomechanics;Cartilage;cartilage degradation;Cartilage Matrix;Catabolism;Cell Culture Techniques;cell type;Chemicals;Chondrocytes;COL6A3;Collagen Type VI;cytokine;Cytoskeleton;Degenerative polyarthritis;disability;Disease;disease model;Disease Progression;disorder prevention;disorder risk;DNA Sequence Alteration;early onset;Elasticity;Environment;Environmental Risk Factor;environmental stressor;Equilibrium;exome sequencing;exposed human population;Exposure to;Extracellular Matrix;Fluorescence Recovery After Photobleaching;Gene Expression;Gene Modified;Genes;Genetic;Homeostasis;human induced pluripotent stem cells;human model;IL6 gene;In Situ;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interleukin-1;Ion Channel;joint inflammation;Knock-out;Link;Measures;mechanical drive;mechanical load;mechanical properties;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Mediator;Metabolic;Modeling;Modulus;Molecular;Molecular Biology;Mutate;Mutation;novel;Onset of illness;Pain;Pathogenesis;Pathway interactions;Perception;Persons;Physiological;Predisposition;Production;Property;Proteins;Research;response;Risk;Risk Factors;Role;Signal Transduction;symptom management;targeted treatment;Testing;therapeutic development;Therapeutic Uses;Tissues;Training;transmission process;United States;Weight-Bearing state;Work

PROJECT_TITLE: The Impact of COL6A3 Mutation on Inflammatory Susceptibility in Osteoarthritis


ORG_CITY: LAWRENCE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative In the US, there are ~795,000 cases of stroke annually with 140,000 deaths making stroke the 3rd leading cause of death. While there are therapies for certain types of stroke, for example recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke, <7% of patients actually receive therapy in part due to the lack of an in vitro diagnostic that can supply information on patient management within the short (<4.5 h) therapeutic time window. In this R01 application, an innovative set of tools will be developed along with the associated biomarkers to realize delivery of an in vitro diagnostic test for stroke. In its final rendition, the test will diagnose stroke in ~31 min and use blood plasma as a source of markers (i.e., RNAs secured from extracellular vesicles, EVs).

PI_NAMEs: BAIRD, ALISON E;SOPER, STEVEN ALLAN (contact)

PROGRAM_OFFICER_NAME: MULVANEY, SHAWN PATRICK

PROJECT_TERMS: Acute;Affect;Affinity;Alteplase;Appearance;Biological Assay;Biological Markers;Biotinylation;Blood flow;Blood Tests;blood-based biomarker;Brain;Brain Diseases;Brain hemorrhage;Cause of Death;CD8B1 gene;Cells;Cessation of life;circulating biomarkers;Clinical;Clinical Sensitivity;clinically relevant;Collaborations;Complementary DNA;Coulter counter;Data;design;Detection;Development;Devices;Diagnosis;Diagnostic;diagnostic platform;Diagnostic tests;Emergency Situation;Expression Profiling;extracellular vesicles;Fluorescence;Genetic Transcription;Harvest;Hospitals;Image;In Vitro;in-vitro diagnostics;Injections;innovation;innovative technologies;Ischemic Stroke;Label;Lasers;Length;Leukocytes;Ligase;Light;Magnetic Resonance Imaging;Measurement;Membrane;Messenger RNA;meter;Molds;Molecular;mRNA Expression;multidisciplinary;nano;nanocolumn;nanopore;nanosensors;novel;Oligonucleotide Primers;operation;Output;Patients;Peripheral;peripheral blood;Phase;Plasma;Plastics;point of care testing;Process;Productivity;Rapid diagnostics;Reaction;Recovery;Research;Reverse Transcription;RNA;RNA marker;Sampling;Secure;Sensitivity and Specificity;single molecule;Solid;Source;Stroke;stroke event;stroke model;stroke patient;stroke therapy;Structure;success;Surface;Syndrome;System;Technology;Testing;Therapeutic;Time;tool;Transcript;transcriptome sequencing;Validation;Vascular blood supply;vesicular release;Work;X-Ray Computed Tomography

PROJECT_TITLE: mRNA Expression Profiling from Extracellular Vesicles (EVs): Generating a Rapid Diagnostic for Stroke

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE In the last decade there has been huge progress in identifying the genetic bases of complex diseases. However, it has been much more challenging to interpret the molecular mechanisms through which these genetic variants act to affect disease outcomes. In this project we propose to develop new techniques for studying how disease-associated genes may affect gene regulatory networks in cells, as these are one important step linking genetic variation to disease.

PI_NAMEs: PRITCHARD, JONATHAN K (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Affect;Autoimmune;Autoimmune Diseases;base;Biological Models;Cell Count;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Complex Genetic Trait;Computer software;Computing Methodologies;cost;CRISPR screen;Data;Data Analyses;design;Development;Disease;Disease Outcome;effector T cell;experience;experimental study;Funding;gene network;gene regulatory network;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;Grant;Guide RNA;Immune;improved;Information Networks;interest;Knock-out;knockout gene;Light;Link;Literature;Maps;Measures;method development;Methodology;Methods;Molecular;Pathway interactions;Process;Property;Proteins;Protocols documentation;Regulation;Regulator Genes;Regulatory T-Lymphocyte;Research Personnel;Ribonucleoproteins;RNA library;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Techniques;Technology;tool;trait;transcriptome sequencing;Variant;Work

PROJECT_TITLE: Integration of functional data and GWAS to elucidate genetic basis of diseases

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Rehabilitation

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Cognitive impairment results in decreased ability to complete daily activities such as managing medications, finances, and appointments resulting in care needs. However, one out of four individuals with cognitive impairment lives alone and requires distance caregiving, which is associated with unique challenges compared to in-person caregiving. This study involves developing an integrative stakeholder (care receivers with cognitive impairment and their remote caregivers) co-designed intervention focused on improving use of innovative remote caregiver technology, everyday functioning and independence of care receivers, remote caregiver involvement, and the emotional bond between the dyad.

PI_NAMEs: WEAKLEY, ALYSSA MAE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Agreement;Alzheimer's Disease;Alzheimer's disease related dementia;American;Appointment;Area;asynchronous communication;Behavior Therapy;Calendar;California;care recipients;career;career development;caregiver interventions;Caregivers;caregiving;caregiving outcomes;Caring;Child Rearing;Clinical;cognitive rehabilitation;Couples;Data;Database Management Systems;design;Development;digital;Doctor of Philosophy;Education;Emotional;Emotional Bonds;Employment;Encapsulated;Enhancement Technology;environmental enrichment for laboratory animals;Ethnic Origin;evidence base;Exercise;experience;Familiarity;Family Caregiver;family caregiving;Family member;Focus Groups;functional improvement;Funding;Future;Goals;Habits;Health;healthy aging;Home;Home Page;Impaired cognition;improved;improved outcome;in-home care;Individual;innovation;innovative technologies;Intervention;Interview;K-Series Research Career Programs;Knowledge;Leadership;Life;Long-Term Care;Medication Management;Memory;Mentors;Mentorship;Methods;Modification;multidisciplinary;National Institute on Aging;novel;older adult;Outcome;Participant;Persons;Positioning Attribute;primary caregiver;programs;psychosocial;psychosocial outcome;Race;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Research Project Grants;Resources;Role;Sampling;satisfaction;Schedule;Series;Services;skills;Techniques;Technology;technology intervention;technology training;Testing;therapy design;tool;Training;Universities;uptake;web platform;web-based tool;Work

PROJECT_TITLE: A stakeholder derived intervention to enhance technology engagement and reduce the emotional divide in distance caregiving of older adults with cognitive impairment

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


NIH_SPENDING_CATS: Aging;Arthritis;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Nutrition;Obesity;Osteoarthritis;Pediatric;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Women's Health Research

PHR: PROJECT NARRATIVE Parental high-fat diets that are rich in omega-6 fatty acids have been shown to increase osteoarthritis severity in adult mouse offspring. I hypothesize that maternal obesity programs offspring osteoarthritis risk by epigenetically programming the cells of the developing knee joint. Here we propose that re-balancing the fatty acid ratio in the presence of maternal obesity will improve pregnancy health and protect the offspring from susceptibility to injury-induced osteoarthritis.

PI_NAMEs: OESTREICH, ARIN KETTLE (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Adult;Adult Children;Affect;Animal Model;ATAC-seq;Behavior;Bioinformatics;bisulfite sequencing;Breeding;Candidate Disease Gene;candidate validation;career;career development;cartilage degradation;cartilage development;Cell Nucleus;Cells;Chromatin;chromatin immunoprecipitation;Coupled;cytokine;Data;Degenerative polyarthritis;design;Development;Development Plans;Diagnosis;Diet;dietary;Dietary Component;Dietary Fatty Acid;Dietary Intervention;Disease;DNMT3B gene;Doctor of Philosophy;effectiveness evaluation;Embryo;Epigenetic Process;epigenome;Faculty;FAT gene;Fatty acid glycerol esters;Fatty Acids;fetal;Fetal Growth;Flow Cytometry;Generations;Genes;Genetic;Goals;Growth;Health;High Fat Diet;High Prevalence;Histologic;Hypertension;implantation;improved;in utero;Inflammation;Inflammatory;Injury;Insulin;joint formation;joint injury;Joints;Knee;Knee joint;Life;life span;Limb Development;Macrophage;maternal obesity;Measures;Medial meniscus structure;Metabolic;microCT;Molecular;Morphology;mother nutrition;multiple omics;Mus;Musculoskeletal;Musculoskeletal Development;Musculoskeletal Diseases;Musculoskeletal System;non-alcoholic fatty liver disease;novel;novel strategies;Nucleic Acid Regulatory Sequences;obese person;Obesity;obesity in pregnancy;obesogenic;offspring;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Operative Surgical Procedures;Outcome;Overnutrition;Pain;Pharmaceutical Preparations;Placenta;Population;Positioning Attribute;Predisposition;Pregnancy;pregnancy health;prenatal;Prenatal Nutrition;progenitor;programs;Regulation;Reproduction;Research;Research Personnel;Risk;Role;Secondary to;Serum;Severities;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;skills;stem cells;subchondral bone;Synovitis;Testing;Training;transcriptome;transcriptomics;Transgenic Mice;Transgenic Organisms;translational approach;Vitamins;western diet;Work

PROJECT_TITLE: The role of maternal obesity in osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The proposed research will provide a fundamental mechanistic understanding of the photoreceptor cilium and the way disk membranes form to create the outer segment. Numerous retinal degenerations are related to the photoreceptor cilium, so that the studies will also provide a scientific framework for understanding the pathogenesis of these degenerations. Indeed, defects in the photoreceptor cilium are often related to defects in other cilia, in tissues elsewhere in the body, so that the studies may have a wide-ranging benefit to understanding human health and disease.

PI_NAMEs: WILLIAMS, DAVID S (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Cellular Mechanisms of Photoreceptor Disk Morphogenesis

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Congenital Structural Anomalies;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Pediatric;Pediatric Cancer;Polycystic Kidney Disease;Rare Diseases;Tuberous Sclerosis

PHR: Narrative This project focused on the mechanisms of development and progression of kidney disease in tuberous sclerosis complex (TSC), an autosomal dominant disease in which renal disease (including cystic disease, which can resemble autosomal dominant polycystic kidney disease [ADPKD]) is the second leading cause of death. We hypothesize that CD206-positive macrophages and expression of B7-H3 on TSC2-deficient cells cooperate to promote cell survival and growth in TSC. Targeting these pathways could lead to completely novel therapeutic strategies for children and adults with TSC.

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Angiomyolipoma;Antibodies;antibody detection;Area;Autosomal Dominant Polycystic Kidney;autosome;Benign;Bilateral;Body mass index;Carcinoma;Cause of Death;CD276 gene;CD8-Positive T-Lymphocytes;cell growth;Cell Physiology;Cell Proliferation;Cell Surface Proteins;Cell Survival;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Child;Childhood;Chronic;Clinical;clinical development;Clinical Trials;Complex;Couples;Cyst;Cystic kidney;Data;Development;Disease;early childhood;Epithelium;Fatty acid glycerol esters;FRAP1 gene;Genetic;Germ Lines;Growth;Hemorrhage;Homologous Gene;Human;human data;Immune;immune checkpoint;Immunological Models;immunoregulation;Immunosuppression;immunosuppressive macrophages;improved;In Vitro;in vivo;Individual;infancy;Infection;inhibitor;innovation;Kidney;Kidney Diseases;Knockout Mice;Lead;Lesion;Life;Lipids;loss of function mutation;Macrophage;Membrane Glycoproteins;Morbidity - disease rate;Morphology;mortality;mouse model;mTOR inhibition;Mus;Myeloid-derived suppressor cells;nano-string;novel;novel therapeutic intervention;Null Lymphocytes;Pathway interactions;Patients;Peptides;Phenotype;PKD1 gene;Play;Polycystic Kidney Diseases;Pre-Clinical Model;preclinical efficacy;programmed cell death ligand 1;protein complex;Proteins;Proteomics;Renal Angiomyolipoma;Renal Cell Carcinoma;response;Seizures;single-cell RNA sequencing;Smooth Muscle;Specimen;Testing;Therapeutic;therapeutic target;transcriptomic profiling;TSC1 gene;TSC1/2 gene;TSC2 gene;Tuberous Sclerosis;tumor-immune system interactions;Work

PROJECT_TITLE: Mechanisms of immunosuppression in the development and progression of renal disease in Tuberous Sclerosis Complex

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE The Vision Science Training Program in Oklahoma will recruit and train students pursuing a PhD or MD degree (pre-doctoral trainees) or individuals who already have the PhD or MD degree (postdoctoral trainees) to perform clinical and basic science research in vision science. An outstanding group of investigators spanning several departments and two institutions has interfaced to create a collaborative and highly competitive, yet nurturing environment for our trainees to excel. Training in research laboratories of well-funded, highly productive, and nationally and internationally recognized scientists, along with a strong program in vision science course work, retreats/workshops, clinical experiences, and national/international meetings will provide training critical for future vision scientists in the United States.

PI_NAMEs: CALLEGAN, MICHELLE C (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;vision science

PROJECT_TITLE: Vision Science Training Program


NIH_SPENDING_CATS: Mental Health;Telehealth

PHR: Narrative Our Multidisciplinary Training Program in Digital Mental Health is the first in the nation to co-train postdoctoral fellows with backgrounds in behavioral and psychological sciences and human-computer interaction. The program admits roughly equivalent numbers of fellows from each domain. The program uses a co-training model, in which fellows from both domains work together in research and have mentors from both behavioral and psychological sciences and human computer interaction.

PI_NAMEs: GERGLE, DARREN ;MOHR, DAVID CURTIS (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: digital mental health;multidisciplinary;Training Programs


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE. The visual cycle regenerates key light-sensitive opsin pigments that are essential for vision- these opsins are chemically changed by light exposure, and needs to be rapidly converted back to their initial “dark” state for vision to be sustained in the retina. Impairments of this visual cycle lead to the buildup of toxic molecular intermediates, which kill cells of the retina and potentiate vision loss. In this proposal, I will test if artificially consolidating key visual cycle enzymes into photoreceptor cells can reduce the buildup of these toxic intermediates, exploring their potential in prolonging retinal health and vision.

PI_NAMEs: ENGFER, ZACHARY JOHN (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 11 cis Retinal;11-cis-Retinol;Affect;Age;All-Trans-Retinol;Back;Binding;Biochemical;Biochemical Pathway;Biochemistry;Blindness;Brain;Cell Death;cell killing;cell type;Cells;Chemicals;chromophore;Chronic;Cone;Coupled;Coupling;crosslink;Darkness;Defect;Degenerative Disorder;Disease;Electrophysiology (science);Electroretinography;Engineering;Enzymes;Esters;Ethanolamines;experience;Eye;Fatty Acids;Functional disorder;Future;Genetic;Health;Helper-Inducer T-Lymphocyte;High Pressure Liquid Chromatography;Human;Immunohistochemistry;Immunology;Isomerism;Kinetics;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Knowledge;Lasers;Lead;lecithin-retinol acyltransferase;Light;Link;Molecular;Molecular Biology;Molecular Evolution;Morphology;mouse model;Muller's cell;Mus;Natural regeneration;Ophthalmoscopy;Opsin;Optic Nerve;Optical Coherence Tomography;Patients;Phenotype;Photoreceptors;Phototransduction;Physiological;Pigments;Proteins;Quality of life;Reaction;Recycling;Regenerative pathway;remediation;Research Technics;Resistance;Retina;retinal damage;Retinal Degeneration;Retinal dehydrogenase;Retinal Diseases;Retinal Dystrophy;Retinal Pigments;Retinoids;Retinol dehydrogenase;retinol isomerase;Rod;RPE65 protein;Scanning;sex;Signal Transduction;stem;Structure of retinal pigment epithelium;Supporting Cell;Testing;Therapeutic;therapeutic gene;Therapeutic Intervention;Training;Travel;treatment optimization;Vertebrate Photoreceptors;Vision;vision science;Visual;visual cycle;Visual Fields;Visual impairment;Work

PROJECT_TITLE: Recapitulation of the two-cell visual cycle in photoreceptors and its effects on retinoid flux and remedy of toxic retinoid species


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Prevention;Telehealth

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Traditional clinical research studies that require travel to a research site for in-person assessments place undue burden on participants with Parkinson’s disease, particularly as the disease advances, and fail to capture the range and complexity of Parkinson’s disease. This project will extend the remote follow-up of two clinical trial cohorts using video visits, remote patient reporting, smartphones, and wrist-worn sensors. By addressing some of the limitations of traditional assessments and evaluating new methods for predicting events like falls and cognitive impairment, we will help to accelerate the development of new treatments for people with Parkinson’s disease.

PI_NAMEs: SCHNEIDER, RUTH  (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Acceleration;actigraphy;Address;Affect;Biological;Cellular Phone;Charge;Clinical;clinical care;clinical development;clinical phenotype;clinical predictors;Clinical Research;Clinical Trials;clinically relevant;Cognitive;cohort;Collection;COVID-19 pandemic;Data;Data Collection;Data Set;Decentralization;Development;digital assessment;digital phenotyping;digital tool;disability;Disabling;Disease;Disease Outcome;Disease Progression;Early identification;Evaluation;Event;experience;fall risk;falls;fitbit;fitness;follow-up;Frequencies;Funding;Gait;genome sequencing;Geography;Goals;Health Services Accessibility;Heart Rate;Heterogeneity;high risk;Home;illness length;Impaired cognition;improved;Individual;insight;Institutionalization;Knowledge;Link;Longitudinal Studies;Measures;Methods;Modeling;Moods;Morbidity - disease rate;mortality;Motor;National Institute of Neurological Disorders and Stroke;Natural History;Nervous System Disorder;Neurodegenerative Disorders;novel therapeutics;Observational Study;Outcome;Outcome Measure;Parkinson Disease;Participant;patient oriented;Patient Outcomes Assessments;Patient Self-Report;Patients;Persons;Pharmaceutical Preparations;Phase III Clinical Trials;Phenotype;Physical activity;Physical assessment;Plasma;Population;posture instability;Qualifying;Questionnaires;Refractory;remote assessment;Reporting;Research;Research Methodology;research study;Risk;sensor;Site;Sleep;sleep pattern;smartphone application;smartphone based assessment;Source;Surveys;Symptoms;telehealth;therapeutic development;Time;tool;Training;Travel;Tremor;United States National Institutes of Health;video visit;whole genome;Wrist

PROJECT_TITLE: Assessing Tele-Health Outcomes in Multiyear Extensions of Parkinson's Disease Trials-2 (AT-HOME PD-2)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]