ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Statins are a widely used class of lipid-lowering medication, yet, little is known about their effect on the risk of Alzheimer’s disease and related dementias (ADRD). In this project, we will leverage a unique opportunity to create a quasi-experiment using a clinical guideline in the UK and established statistical methods in economics to study the effect of statins on ADRD risk overall, and across relevant subgroups.

PI_NAMEs: CALONICO, NESTOR SEBASTIAN;ODDEN, MICHELLE CHRISTINA;ZEKI AL HAZZOURI, ADINA  (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Accounting;Address;Adherence;Adult;Adverse event;Age;Age Years;aged;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Antiinflammatory Effect;cardioprotection;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Caring;Characteristics;Chronic;Clinical;Code;Cognition;Cognitive;cognitive function;comorbidity;Computerized Medical Record;Coupled;Data;Data Sources;Databases;dementia risk;design;Drug Prescriptions;econometrics;Economics;Effectiveness;Elderly;electronic data;Electronic Health Record;Event;Exclusion;experience;flexibility;follow-up;forest;General Population;General Practices;Guidelines;Health;Heart;Impaired cognition;improved;inclusion criteria;Individual;innovation;interest;Intervention;Knowledge;learning strategy;Lipids;Machine Learning;machine learning method;Memory Loss;Methods;Modeling;Modernization;Natural experiment;novel;Observational Study;Outcome;Participant;patient subsets;Patients;Pharmaceutical Preparations;Placebo Control;Placebos;Population;Population Intervention;pragmatic trial;Pravastatin;precision medicine;Prevalence;Prevention approach;Prevention strategy;Prospective Studies;Public Health;Quasi-experiment;randomized trial;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Risk;Role;Safety;Sample Size;sex;side effect;Statistical Methods;Subgroup;supervised learning;Techniques;Time;treatment effect;United Kingdom;United States Food and Drug Administration;United States National Institutes of Health;Woman

PROJECT_TITLE: Illuminating our understanding of statins and Alzheimers Disease and Dementia using modern causal inference methods

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Pediatric;Precision Medicine;Prevention

ORG_CITY: CINCINNATI

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Pediatric emergency department visits for anaphylaxis have tripled during the past decade, with mandatory prolonged observation periods driving emergency department overcrowding and excessive healthcare costs. There is a need for personalized clinical prediction models and the discovery of prognostic biomarkers to enhance patient risk stratification, optimize observation periods and prevent unnecessary hospitalizations. The research goals of this K23 award are consistent with the mission of NIAID, to better understand, treat, and ultimately prevent allergic diseases, and will improve patient outcomes and optimize healthcare utilization.

PI_NAMEs: DRIBIN, TIMOTHY ERICK (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Accident and Emergency department;Address;Allergic Disease;Anaphylaxis;Automobile Driving;Basophils;Biological Markers;Biological Products;Biology;biomedical informatics;Biometry;Cardiovascular system;career development;Caring;Characteristics;Child;Clinical;clinical care;clinical predictive model;clinically actionable;cohort;Communities;Consensus;Crowding;Data;Derivation procedure;Development;diagnostic accuracy;diagnostic biomarker;Dose;Emergency Care;Emergency department visit;Enrollment;Epinephrine;Exhibits;Funding;Goals;Guidelines;hands-on learning;Health Care Costs;health care service utilization;Healthcare Systems;Histamine;Home;Hospitalization;Hour;Human;IgE;IL8 gene;Immunologics;Immunology;improved;Infant;Infrastructure;infrastructure development;Investigation;Knowledge;Life;Machine Learning;mast cell;Measures;Mediating;Mediation;Mentored Patient-Oriented Research Career Development Award;Mission;Modeling;National Institute of Allergy and Infectious Disease;neutrophil;Neutrophil Activation;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;Patient risk;patient stratification;Patient-Focused Outcomes;Patients;pediatric emergency;Peroxidases;personalized care;Phase;Plasma;predictive modeling;prevent;prognostic;Prognostic Marker;Prospective cohort;Prospective Studies;Reaction;Refractory;Research;research and development;Research Personnel;Resolution;Retrospective cohort;Risk;Risk Factors;risk stratification;Role;S100A12 gene;Serum;Severities;skills;success;Symptoms;System;Testing;Therapeutic;Time;tool;Training;translational approach;translational scientist;treatment response;Tryptase;Urine;validation studies;Wait Time;Wheezing

PROJECT_TITLE: Improving Anaphylaxis Outcomes Through Personalized Care Strategies

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Alzheimer’s disease (AD) and other neurodegenerative diseases involve a loss of brain function and brain cells over time and eventually cause death, affecting one third of people over the age of 85. Recent research has found that brain cells build up new mutations in the DNA (known as somatic mutations) in AD, which appears to harm the brain cells. This proposal will test how somatic mutations are related to the progression of AD in the brain, and how they are related to the buildup of misfolded proteins amyloid-β and tau.

PI_NAMEs: MILLER, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta oligomer;Affect;Age;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Anatomy;association cortex;Autopsy;Biological;Brain;brain cell;Brain region;brain tissue;Cause of Death;Cell model;Cell Nucleus;Cells;Clinical;Cognitive;Data;Dementia;Deposition;Development;Disease;Disease Progression;DNA;DNA Damage;Event;Freezing;Functional disorder;Genome;genome sequencing;genome-wide;Genomics;Human;human tissue;Incubated;Individual;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Investigation;Link;Maps;medial temporal lobe;Methods;misfolded protein;Molecular;Mutation;Neoplasms;Neurodegenerative Disorders;neurofibrillary tangle formation;neuron loss;Neurons;normal aging;novel;novel sequencing technology;novel strategies;oxidation;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathology;Persons;Play;progressive neurodegeneration;Proliferating;protein misfolding;regional difference;Research;Role;Signal Transduction;Single Nucleotide Polymorphism;Somatic Mutation;Sorting;Stage Grouping;Staging System;stem;Stereotyping;System;tau aggregation;tau Proteins;tau-1;Technology;Testing;Time;Tissue Sample;Tissues;Variant;variant detection;whole genome

PROJECT_TITLE: Mechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron Analysis

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Human Genome

ORG_CITY: AUGUSTA

ORG_DEPT: PEDIATRICS

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The lack of diversity among the US biomedical research workforce remains a significant challenge. However, it is clear that expanding research technical skills combined with novel mentoring approaches are essential components of programs seeking to increase diversity. The Program to Increase Diversity Among Individuals Engaged in Health-Related Research- Functional and Translational Genomics of Blood Disorders, at Augusta University will address these challenges by providing intensive mentoring and research experiences, to develop competitive grant applications, and increase diversity of the US biomedical workforce.

PI_NAMEs: PACE, BETTY SUE (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Academic support;Accountability;Achievement;Address;Administrative Supplement;African American;Applications Grants;Basic Science;Behavioral Sciences;Biomedical Research;Cardiovascular system;career;career development;Clinical Research;cohort;Collaborations;Committee Members;Data;Development;disabled;Disadvantaged;Educational Curriculum;Educational process of instructing;empowerment;Ethnic Population;experience;Extramural Activities;Faculty;Fostering;functional genomics;Funding;Funding Mechanisms;Future Teacher;Goals;Grant;Grant Review;Growth;hands-on learning;Health;health disparity;Hematological Disease;Home;improved;Individual;Inequity;innovation;Institution;Leadership;matriculation;meetings;member;Mentors;Mentorship;Monitor;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Obesity;Outcome;parent grant;peer;Principal Investigator;Private Sector;Process;Program Evaluation;programs;Protein Analysis;Public Sector;Publications;racial population;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Science;Scientist;Series;skills;statistics;Study Section;success;summer institute;Technical Expertise;Testing;Texas;Training;Training Programs;Training Support;translational genomics;Translational Research;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman;Writing

PROJECT_TITLE: PRIDE-Functional and Translational Genomics of Blood Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O2)]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Physical Activity;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Promoting physical activity and healthy food intake in patient-centered ways is key to improving heart health in rural areas. This project will use a new digital health tool called PREVENT to improve healthcare quality in rural communities by providing tailored physical activity and food intake goals and offering resources and Community Health Worker support to overcome barriers to healthy behaviors. This project will provide a foundation for the candidate’s career as an independent investigator by providing focused training and the data to support a larger study of PREVENT.

PI_NAMEs: KEPPER, MAURA  (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Adult;American Heart Association;Award;Awareness;Behavior;behavior change;Behavior Therapy;Body mass index;Cardiac health;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;career;career development;Caring;chronic care model;Chronic Disease;Clinic;Clinic Visits;Collaborations;Communities;Community Health Aides;Counseling;County;Data;design;Diabetes Mellitus;digital health;dissemination science;Eating;Effectiveness;Electronic Health Record;Equity;Evaluation;evidence base;experience;Federally Qualified Health Center;Feedback;follow-up;Foundations;Future;Goals;Health behavior;Health behavior and outcomes;health care quality;health equity;Health equity research;Health Food;Healthcare;healthy weight;implementation protocol;implementation science;improved;Institution;International;Interview;K-Series Research Career Programs;Leadership;Life;Low income;Maps;Medical Care Team;member;Mentored Clinical Scientist Development Program;Mentors;Methodology;Methods;Missouri;mortality;Motivation;Multiple Partners;obese patients;Obesity;obesity management;Overweight;Patient Care;patient engagement;patient oriented;Patients;Physical activity;Pragmatic clinical trial;Prevalence;prevent;primary care team;Process;programs;Quality of Care;randomized trial;Recommendation;recruit;Reporting;Research;Research Methodology;Research Personnel;Resources;Rural;rural area;Rural Community;Rural Health;rural health clinic;rural patients;rural setting;Science;skills;social;Structure;success;technology intervention;Testing;tool;Training;United States;United States Health Resources and Services Administration;Visual;Work

PROJECT_TITLE: K01 Career Development Award

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Sleep Research

ORG_CITY: CORAL GABLES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The goal of the Behavioral Medicine and Sleep Disorders Institute (BSM PRIDE) at the University of Miami is to continue to increase diversity in the academic workforce. This will be achieved by providing congruent mentored learning experience to an additional cadre of 48 URM faculty pursuing careers aiming at cardiovascular risk reduction through implementation of translational behavioral models. Trained URM faculty will be empowered to develop independent careers in behavioral medicine and sleep disorders research, applying innovative methods to improve health equity in minoritized communities.

PI_NAMEs: JEAN-LOUIS, GIRARDIN  (contact);RUNDEK, TATJANA

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Academic achievement;Achievement;Address;Area;Award;Behavior;Behavioral;Behavioral Medicine;Behavioral Model;Behavioral Sciences;Biometry;cardiovascular risk factor;career;Characteristics;circadian;Communities;Consultations;Critiques;Data;Development Plans;Disease;Educational Curriculum;Educational workshop;effectiveness evaluation;empowerment;Enrollment;Ensure;Environment;Ethics;Evaluation;evidence base;experience;Exposure to;Faculty;Feedback;follow-up;Funding;Goals;Grant;health equity;improved;Individual;innovation;intrinsic motivation;Knowledge;Leadership;Learning;Measures;Medicine;meetings;Mentors;Mentorship;Methodology;Methods;minority communities;minority scientist;Modeling;Monitor;National Heart, Lung, and Blood Institute;Neurology;novel;Online Systems;Outcome;peer;peer coaching;Peer Review;Persons;Planning Theory;Positioning Attribute;professor;Program Evaluation;Program Research Project Grants;programs;Protocols documentation;Psychiatry;Publications;Publishing;Qualifying;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Proposals;resilience;Resources;Risk Reduction;Science;Scientist;Self Efficacy;Sleep;Sleep Disorders;social cognitive theory;Social support;Study Section;success;tool;Training;Underrepresented Minority;United States;United States National Institutes of Health;Universities;webinar;Work;Workforce Development;Writing

PROJECT_TITLE: Program to Increase Diversity in Behavioral Medicine and Sleep Disorders Research


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: STRATFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

ORG_STATE: NJ

PHR: A hallmark of many neurodegenerative diseases, including Amyotrophic Lateral Sclerosis and Alzheimer’s disease, is the cytoplasmic accumulation of TDP-43, a nuclear DNA/RNA binding protein. This research proposal will use both yeast and mammalian models of TDP-43 to uncover the molecular role cyclin C plays in TDP-43 toxicities.

PI_NAMEs: COOPER, KATRINA FRANCES (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;alpha synuclein;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Animals;Applications Grants;Binding;Biological Models;Biology;Cell Culture Techniques;Cell Death;Cell Line;Cell Nucleus;Cell Separation;Cell Survival;cell type;Cells;Central Nervous System;chemical genetics;Complex;cyclin C;Cyclin-Dependent Kinases;Cytoplasm;Cytoprotection;cytotoxicity;Data;Development;Disease;Disease Progression;DNA;Dynamin;Enzymes;Fluorescence Microscopy;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;genetic approach;Genetic Transcription;Goals;Grant;Guanosine Triphosphate Phosphohydrolases;Homologous Gene;Human;In Vitro;insight;Laboratories;Lewy Body Disease;Link;Mammalian Cell;Mediating;Mediator;member;misfolded protein;Mitochondria;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Modeling;Molecular;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Nuclear;Outer Mitochondrial Membrane;overexpression;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Phosphotransferases;Play;preservation;prevent;Primary Lateral Sclerosis;Prion Diseases;Process;Production;protein aggregation;protein TDP-43;Proteins;Reactive Oxygen Species;Reagent;Recombinants;Repression;Research Proposals;response;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;Saccharomycetales;Series;Stress;System;TDP-43 aggregation;Testing;Toxic effect;Work;Yeasts

PROJECT_TITLE: The Role of Cyclin C in mediating neurodegenerative proteinopathies

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: Abdominal aortic aneurysm (AAA) is a common tobacco-related condition in which progressive dilatation of the largest blood vessel in the abdomen leads to rupture and approximately 41,000 deaths world-wide annually. Given that the major risk factors for AAA include advanced age, male sex, and a history of tobacco use, it is not surprising that AAA disease is relatively common in the Veteran population. There are currently no medical therapies that prevent AAA development, rupture, or aneurysm-related death. We propose to study and identify the key mechanisms behind nicotine-induced acceleration of AAA disease, with the ultimate goal of finding novel pharmacological or genetic therapies that could inhibit AAA growth and prevent associated sickness and death. This line of research may also add insight as to how other forms of environmental exposures impact chronic cardiovascular diseases.

PI_NAMEs: TSAO, PHILIP S (contact)

PROJECT_TERMS: Abdomen;Abdominal Aortic Aneurysm;Acceleration;Acetylation;Address;Aneurysm;Aorta;Behavior;Binding;Blood Vessels;Bromodomain;Cardiovascular Diseases;cell behavior;Cell Culture Techniques;cell type;Cells;Cessation of life;Characteristics;ChIP-seq;chromatin remodeling;Chronic;clinical translation;CRISPR/Cas technology;Cultured Cells;Development;Dilatation - action;Disease;DNA;DNA Methylation;Elderly;Electronic cigarette;electronic cigarette use;Enhancers;Environment;Environmental Exposure;Epidemiology;Epigenetic Process;epigenome;Event;experimental study;Exposure to;Gene Expression;gene therapy;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Growth;Growth and Development function;Health;Histone Acetylation;Human;Immunofluorescence Immunologic;in silico;In Vitro;Individual;Inflammation;Inflammatory;insight;Interruption;Intervention;Intervention Trial;Life;Link;Location;male;Medical;military veteran;Modeling;modifiable risk;Modification;Molecular;Monitor;mouse model;Mus;Nicotine;nicotine inhalation;novel;Oxidative Stress;Pathway Analysis;pharmacologic;Phenotype;Play;prevent;programs;Proteins;Reagent;Recording of previous events;Research;Resolution;response;Risk Factors;Role;Rupture;sex;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;Smoking;Testing;Therapeutic;therapeutic target;Time;Tissues;Tobacco;Tobacco use;Toxic Environmental Substances;transcription factor;transcriptome;transcriptomics;translational therapeutics;vaping;vaping nicotine;vascular inflammation;Veterans;Work

PROJECT_TITLE: E-cigarette Nicotine Induces Epigenetic Changes in Vascular Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 CARB-R (01)]


FUNDING_MECHANISM: OTHERS

ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

ORG_STATE: IN

PHR: The veteran population develops chronic kidney disease (CKD) at a higher rate than the general population. Patients with CKD are at an increased risk of fracture and if a fracture occurs, patients with CKD have a greater risk of death compared to other populations. Unfortunately, treatments aimed at reducing fracture risk in CKD patients are limited in part due to the lack of extensive studies. My research program is focused on understanding causes of bone fragility in CKD and working on approaches to minimize fracture risk. Beyond CKD, bone loss from other conditions (such as osteoporosis) affects millions of Veterans and thus our work in CKD has far reaching implications. The results of this work will provide a basis for improving the quality of life of veterans at risk of bone loss and fracture.

PI_NAMEs: ALLEN, MATTHEW R (contact)

PROJECT_TERMS: Academia;Adverse effects;Affect;Age;Aging;Alcohol consumption;American;Animal Model;Area;Award;Biological Markers;Biology;Biopsy;bone;bone fragility;bone loss;bone preservation;bone quality;Bone remodeling;Bone Resorption;Bone structure;Bone Tissue;bone turnover;Book Chapters;Books;career;Career Mobility;caregiving;Cell Physiology;Cessation of life;Chronic;Chronic Kidney Failure;Clinical;clinical investigation;Clinical Research;Clinical Sciences;clinically relevant;Collagen;Death Rate;design;Diabetes Mellitus;Disease;early-career faculty;editorial;efficacy testing;Endocrinology;experience;experimental study;Fracture;fracture risk;Future;Future Generations;General Population;Goals;Grant;Growth;Health;Heart Diseases;High Prevalence;high school;Histologic;Hospitalization;Human;human tissue;Hydration status;IACUC;Impairment;improved;Incubators;indexing;Indiana;Individual;Institution;International;Intervention;Journals;Kidney;Laboratories;Life Style;mechanical properties;Mechanics;medical schools;member;Mentors;Metabolism;MicroRNAs;mid-career faculty;military veteran;Minerals;Modification;Morphology;mortality;mortality risk;Musculoskeletal;nanoindentation;Nephrology;next generation;novel marker;novel strategies;opioid use;Osteogenesis;Osteoporosis;Outcome;Patients;Persons;pharmacologic;physical inactivity;Population;Porosity;Post-Traumatic Stress Disorders;precision medicine;preclinical study;Prevalence;Process;programs;Publications;Publishing;Quality of life;Regimen;Research;Research Personnel;Resources;Risk;Risk Factors;Role;Scientist;Services;skeletal;skeletal tissue;Skeleton;Smoking;Societies;socioeconomic disadvantage;Students;Study Section;Support System;targeted treatment;Testing;Textbooks;Tissues;translational potential;Translational Research;Treatment Efficacy;Underrepresented Populations;United States National Institutes of Health;Veterans;Work;Workforce Development

PROJECT_TITLE: BLRD Research Career Scientist Award Application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 RCSR-N (01)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunotherapy;Pain Research;Palliative Care

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Adoptive cellular therapy (ACT) is a complex, novel, and potentially life-saving therapy for patients with hematologic malignancies but is associated with significant toxicities, high symptom burden, and extreme prognostic uncertainty which results in poor end of life (EOL) outcomes. This clinical research and career development proposal will support an early stage investigator to refine and test a palliative care (PC) intervention (PEACE) tailored to the needs of patients receiving ACT and their caregivers given their profound unmet supportive care needs. The intervention aims to improve the quality of life, symptoms, coping, prognostic understanding, and EOL communication of patients receiving ACT and their caregivers and will lay the foundation to demonstrate the role of PC for improving the quality of care and lived experience of these patients and their families.

PI_NAMEs: JOHNSON, PATRICK CONNOR (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: acceptability and feasibility;Active Learning;Address;Adoptive Cell Transfers;Advisory Committees;anxiety symptoms;Award;Awareness;CAR T cell therapy;care giving burden;care preference;career;career development;Caregiver Burden;Caregivers;Cessation of life;clinical care;Clinical Research;Clinical Trials;clinically significant;Complex;coping;cytokine release syndrome;Data;depressive symptoms;Disease Progression;end of life;end of life care;end of life outcomes;end-of-life communication;Enrollment;Evaluation;experience;Face;Failure;Family;Fatigue;Fever;Five-Year Plans;Foundations;Funding;Genetic Engineering;Goals;Headache;health care service utilization;Hematologic Neoplasms;Hospitalization;Hospitals;improved;Intervention;Life;Life Experience;Lived experience;Longitudinal Studies;loved ones;Lymphocyte;Malignant Neoplasms;manufacture;Medical Oncologist;medical specialties;Mentors;Mentorship;Monitor;Names;Nausea;neurotoxicity;novel;Oncology;Outcome;Palliative Care;Participant;Patient Care;Patient-Focused Outcomes;Patients;physical symptom;Physicians;Pilot Projects;pilot test;pilot trial;Population;Positioning Attribute;prognostic;programs;psychological symptom;Qualitative Research;Quality of Care;Quality of life;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;research and development;Research Methodology;Research Personnel;Role;satisfaction;Seizures;skill acquisition;skills;Solid Neoplasm;Supportive care;Symptom Burden;Symptoms;Testing;Time;Toxic effect;Training;treatment as usual;trial design;Uncertainty;Work

PROJECT_TITLE: Defining the Role of Palliative care for Patients with Hematologic Malignancies Undergoing Adoptive Cellular Therapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: PSYCHOLOGY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Emotional disorders are among the primary causes of disability and impairment worldwide, but predicting their course, which can be used to improve disease management and to deliver more timely and individually tailored treatment, is notoriously difficult. We propose to create a precision-medicine framework for predicting emotional disorder symptoms that leverages theoretically relevant time-series measures using modern “forecasting” machine learning methods. By promoting more accurate predictions of future symptom changes and just-in-time interventions for emotional disorders, this framework will provide a foundation for alleviating one of the major causes of disease and financial burden worldwide.

PI_NAMEs: CURTISS, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: adaptive intervention;Address;Affect;Anxiety;Behavior;Behavior Disorders;burden of illness;career development;Cellular Phone;Competence;Complex;Computational Technique;Computer Models;Data;Data Reporting;design;Diagnostic;disability;Disease;Disease Management;Disease Progression;dynamic system;Ecological momentary assessment;Economic Burden;Emotional;emotional behavior;Emotional disorder;emotional symptom;evidence base;Financial Hardship;Foundations;Future;General Hospitals;Heart Rate;Impairment;improved;Individual;individualized medicine;innovation;Intervention;Jordan;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;machine learning model;Massachusetts;Measures;medical schools;Mental Depression;Mentors;Modeling;Modernization;Monitor;Nature;Notification;Pathology;Patient Self-Report;Patients;Performance;personalized care;Phenotype;precision medicine;predictive modeling;Prevalence;Procedures;prognostic;programs;Property;Psychopathology;recruit;Research Activity;Resources;response;sensor;Series;Signal Transduction;Symptoms;technique development;Techniques;Theoretical model;theories;Time;Training;Training Activity;treatment planning;unsupervised learning

PROJECT_TITLE: Forecasting emotional disorder symptoms: A dynamical systems and time-series machine learning approach

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

PHR: PROJECT NARRATIVE This project will provide mechanistic insight and novel therapeutic targets for treating cognitive dysfunction in Rett syndrome, a neurodevelopmental disorder with loss of cognitive, motor and sensory function in early childhood. The project uses a novel human cerebral organoid model–3D neuronal cultures generated from induced pluripotent stem cells from patients with Rett syndrome–to study how brain cells form functional connections in early life and how these networks are altered by the genetic change in Rett syndrome. Our goal is to identify strategies for restoring cellular-scale brain network activity and development to reduce disability and enable children and adults with Rett syndrome to more fully participate in their family and community life.

PI_NAMEs: MIERAU, SUSANNA  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Affect;Age Months;Air;Allogenic;autism spectrum disorder;Behavioral;Birth;boys;Brain;brain cell;Calcium;Case Study;Cell model;cell type;Cells;Cerebrum;Child;Cognition;Cognition Disorders;Cognitive;cognitive function;Communities;computerized tools;Data;Defect;density;Development;disability;early childhood;Electric Stimulation;Ensure;excitatory neuron;Family;Female;Functional disorder;Funding;Future;gene therapy;Generations;Genes;girls;Goals;Human;Image;Impaired cognition;Impairment;improved;In Vitro;in vitro Model;Independent Scientist Award;infancy;information processing;inhibitory neuron;insight;Interneurons;Language;laser capture microdissection;Lead;Life;life span;Liquid substance;loss of function mutation;Mediator;Methyl-CpG-Binding Protein 2;Microelectrodes;Modeling;Motor;mouse model;Mus;Mutation;N-Methyl-D-Aspartate Receptors;Necrosis;network dysfunction;Neurodevelopmental Disorder;neuron development;neuronal circuitry;Neurons;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;optogenetics;Organoids;Outcome;Parvalbumins;patient derived induced pluripotent stem cells;Patients;pharmacologic;premature;Preparation;prevent;Research;Rett Syndrome;screening;Sensory;single-cell RNA sequencing;skills;social;Symptoms;Synapses;Synaptic Transmission;Testing;three-dimensional modeling;Time;tool;Translating;Vision;Work;X Chromosome;X Inactivation

PROJECT_TITLE: RESTORING CORTICAL NETWORK FUNCTION IN RETT SYNDROME

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine that is accompanied by pain, disability, and irreversible joint damage. Veterans with AS have a high incidence of co-morbidities including cardiovascular disease, inflammatory bowel disease, uveitis, and psoriasis making it a significant public health concern for which there is no cure. Given the diversity in the clinical manifestations of AS, and our limited understanding of the cause of disease, we are currently unable to predict what treatment plan is best for each patient. This project uses a translational research approach to investigate the cellular mechanism by which the AS-associated gene CARD9 controls arthritis-causing T cells in AS and develop a biomarker of treatment responders in the clinic. Our study results may become the basis for new personalized-therapeutic strategies that will improve treatment responses and alleviate Veterans suffering from this debilitating disease.

PI_NAMEs: NAPIER, RUTH  (contact)

PROJECT_TERMS: Affect;Alternative Therapies;Ankylosing spondylitis;Antigen Presentation;Arthritis;Arthritogenic;Autoimmune;autoinflammation;autoinflammatory;Automobile Driving;autoreactive T cell;autoreactivity;Biological Markers;Biological Products;Biological Response Modifiers;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cell Physiology;Cells;chronic back pain;chronic inflammatory disease;Clinic;Clinical;Clinical Research;Coculture Techniques;cohort;comorbidity;cytokine;Cytoplasmic Granules;cytotoxic;Data;Deformity;disability;Disease;Enrollment;extracellular;Funding;Future;Gene Dosage;Genes;Genetic;Genetic Determinism;genetic risk factor;Genetic study;genetic variant;Genotype;Goals;Grant;Health;Heterozygote;Histones;Homeostasis;IL17 gene;Immunity;improved;Incidence;indexing;Individual;individualized medicine;Inflammation;Inflammatory;Inflammatory Arthritis;Inflammatory Bowel Diseases;inhibitor;inhibitor therapy;insight;joint injury;Joints;Knowledge;Mediating;Mediator;microbial;Military Personnel;military veteran;Molecular;Mus;Mutation;Mycoses;Natural Immunity;neutrophil;novel;Outcome;Pain;Pathogenesis;Pathogenicity;Pathologic;patient biomarkers;patient response;Patients;personalized biomarkers;personalized medicine;personalized therapeutic;Pharmaceutical Preparations;Pharmacogenetics;pharmacologic;Physicians;predictive marker;Predisposition;Production;programs;Proteomics;Psoriasis;Public Health;Regulation;Research;response;response biomarker;Role;Sacroiliac joint structure;Serum;Signal Pathway;Signal Transduction;Signaling Molecule;Spinal;Spinal Diseases;spine bone structure;Spondylarthritis;Sterility;Symptoms;synergism;T-Lymphocyte;Testing;Therapeutic;therapy development;Translational Research;treatment planning;treatment responders;treatment response;treatment strategy;Uveitis;Variant;Veterans

PROJECT_TITLE: CARD9 in Ankylosing Spondylitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 IMMA-G (01)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Epilepsy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Tuberous Sclerosis

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE  Drug-resistant epilepsy is a devastating neurological disorder that afflicts approximately 1 million people in the United States who have limited effective treatment options. Brain stimulation is a novel therapy for epilepsy that is adjustable and generally well-tolerated; however, the optimal protocols and underlying mechanisms of neurostimulation in epilepsy remain unknown. The proposed study will explore the temporal and spatial optimization of neurostimulation in epilepsy, and investigate its novel mechanistic effects on disease evolution with the ultimate goal to improve neurostimulation therapy and the lives of people with epilepsy.

PI_NAMEs: FOUTZ, THOMAS  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;Anatomy;Anesthesia procedures;Animal Model;Antiepileptogenic;Award;Basic Science;Biomedical Engineering;Brain;career;career development;Characteristics;Chronic;Chronic Disease;Clinical;clinical training;Data;Deep Brain Stimulation;Development;Development Plans;Devices;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;effective therapy;Electric Stimulation;Electrodes;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;Epileptogenesis;Etiology;Evolution;Excision;Frequencies;Genetic;Goals;Heterogeneity;Hippocampus;Histopathology;Human;improved;in vivo;interpatient variability;Intervention;Intractable Epilepsy;Kainic Acid;Knockout Mice;Location;Long-Term Effects;Medial;Mentorship;Modality;Modeling;mossy fiber;mouse model;Mus;Nervous System Disorder;neural stimulation;Neuroglia;Neurons;neuroregulation;next generation;novel;novel therapeutics;Operative Surgical Procedures;Patients;Persons;Physicians;Precision therapeutics;prevent;Program Development;Proliferating;Protocols documentation;Recurrence;Refractory;Research;Resources;Rodent Model;Scientist;Seizures;skill acquisition;skills;spatiotemporal;statistics;Stimulus;symptomatic improvement;Technology;Temporal Lobe Epilepsy;Testing;Therapeutic Effect;Time;Training;translational scientist;treatment optimization;Tuberous Sclerosis;United States;Universities;Washington;Work

PROJECT_TITLE: Optimization and mechanisms of electrical neurostimulation in mouse models of epilepsy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Social anxiety is associated with significant deficits in social and occupational functioning. The proposed study seeks to evaluate the feasibility of implementing a brief text-based intervention for decreasing social anxiety related safety behaviors among Veterans attempting to re-integrate into the workforce. Findings from this pilot will support a larger randomized controlled study examining the efficacy of the intervention for improving functional outcomes and quality of life among Veterans.

PI_NAMEs: GRUBAUGH, ANOUK L (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Age;Anxiety;arm;barrier to care;Behavior;Behavioral;Benign;Characteristics;Cognitive;Cognitive Therapy;Communities;community reintegration;community setting;Compensation;cost effective;Data;Dissemination and Implementation;Dropout;efficacy evaluation;efficacy outcomes;Employment;Enrollment;Ethnic Origin;Evaluation;Event;Expectancy;experience;Eye;Feedback;Feeling suicidal;follow-up;Fright;Functional impairment;functional improvement;Future;Gender;Goals;Impairment;improved;indexing;Individual;innovation;interest;internet delivery;Intervention;intervention refinement;Intervention Trial;Interview;Light;Loneliness;Major Depressive Disorder;Mental Depression;Methods;Military Personnel;Monitor;Nature;new technology;Occupational;Outcome;Participant;Patients;Persons;Play;post intervention;Post-Traumatic Stress Disorders;premature;Prevalence;prevent;Productivity;programs;Provider;psychosocial;Quality of life;racial population;randomized, controlled study;Randomized, Controlled Trials;Recovery of Function;recruit;Research Design;Research Methodology;Research Personnel;Resources;response;Risk;Role;Safety;Sampling;satisfaction;Self Efficacy;Self-Examination;Services;social;social anxiety;social integration;Social Interaction;social situation;substance use;Substance Use Disorder;success;Suggestion;Surveys;Symptoms;System;Technology;technology intervention;Testing;Text Messaging;text messaging intervention;Time;treatment adherence;Treatment Efficacy;Unemployment;Veterans;Vocation;Work;Workplace

PROJECT_TITLE: Improving Psychosocial Functioning among Veterans with Social Anxiety: A Pilot Evaluation of Self-Monitoring Intervention to Reduce Safety Behaviors

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Diabetic retinopathy is the most common cause of preventable vision loss in the U.S. and disproportionately affects minorities and people with limited socioeconomic resources. The proposed study will co-design, implement, and evaluate a ride-share transportation intervention, adapted from the existing PROgram for Non- emergency TranspOrtation (PRONTO), in patients with diabetic retinopathy residing in neighborhoods with high social vulnerability with a goal to increase adherence to scheduled ophthalmology visits as a critical step in reducing vision loss. This study will prioritize the association of social vulnerability with missed ophthalmology appointments to help guide a targeted patient-centered intervention.

PI_NAMEs: SCANZERA, ANGELICA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Academy;Address;Adherence;Adoption;Adult;Affect;Appointment;Area;Award;blind;Blindness;care providers;career;career development;Caring;Chicago;Chronic;Clinic;Clinical;Communities;Complement;Complications of Diabetes Mellitus;Consolidated Framework for Implementation Research;Data;design;Diabetes Mellitus;Diabetic Retinopathy;Diagnosis;Discipline;Disparity;disparity elimination;Early Diagnosis;Early treatment;Educational workshop;effective intervention;effectiveness/implementation hybrid;effectiveness/implementation study;Electronic Health Record;Eligibility Determination;Equity;ethnic minority;Evaluation;Evidence based intervention;experience;Exposure to;Eye;Eye diseases;Goals;Health;Health Disparities Research;health disparity;health equity promotion;Health Services Accessibility;Health system;Healthcare Systems;high risk;Home;Hospitals;Human;human centered design;Illinois;implementation outcomes;implementation science;implementation strategy;Improve Access;improve minority health;improved;indexing;Individual;individual patient;Institute of Medicine (U.S.);Intervention;Interview;K-Series Research Career Programs;Letters;Managed Care;Maps;Measures;Medicine;Mentors;Mentorship;Methods;Minority;multi-site trial;Names;National Eye Institute;Neighborhoods;novel;Ophthalmology;Outcome;patient oriented;patient-level barriers;Patients;Penetration;Persons;Pilot Projects;pilot test;poor health outcome;Population;post intervention;prevent;primary outcome;Proctor framework;programs;prototype;Proxy;Public Health;racial minority;Recommendation;Reduce health disparities;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resources;Risk;Risk Reduction;Schedule;Services;social vulnerability;socioeconomics;Strategic Planning;stressor;Structural Racism;Surveys;Testing;therapy design;Time;Training;Translational Research;Transportation;underserved area;underserved community;United States National Institutes of Health;Universities;Vision;Visit;Visual;Visual impairment;Work

PROJECT_TITLE: Toward equity in vision health: Using implementation science to adapt a targeted transportation intervention for patients with diabetic retinopathy (PRONTO-EYE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MORGANTOWN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE: Perivascular spaces (PVS) are hypothesized to have roles in brain resilience and disease. To understand their associations in aging and AD, we propose to study PVS metrics in a large, underserved aging population using an automated Frangi filter technique.

PI_NAMEs: MEHTA, RASHI  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Age;age difference;age related;Aging;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;American;Appalachian Region;Area;Assessment tool;Basal Ganglia;Biological;Biological Markers;biomarker performance;Blood Vessels;Brain;Brain Injuries;brain magnetic resonance imaging;Brain region;Cardiovascular system;Clinic;Clinical;clinical imaging;cohort;Communities;comorbidity;computer studies;computerized tools;Data;Data Set;Databases;Dementia;Detection;Diagnosis;diagnostic biomarker;Diagnostic Factor;Disease;Disease Progression;Education;Educational Status;Future;glymphatic system;Health;Homeostasis;Human;Image;image processing;imaging biomarker;Impaired cognition;insight;Investigation;Knowledge;Link;Liquid substance;Literature;Lobar;Lobe;Lymphatic clearance;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Memory;Methods;Microvascular Dysfunction;Midbrain structure;mild cognitive impairment;Nervous System Disorder;Neuroimmunomodulation;neuroinflammation;Neurologic;neuropathology;Neurosciences;novel;novel diagnostics;open source;Parietal;Patients;Persons;Phase;Physiology;Play;Populations at Risk;pre-clinical;Prevalence;prevent;Prognostic Factor;Prognostic Marker;Property;Qualifying;Recording of previous events;Regulation;Reporting;Research;resilience;Resources;response;Rodent;Role;Rural Appalachia;Rural Community;sex;software development;statistics;Techniques;Time;tool;West Virginia;white matter;Work

PROJECT_TITLE: Exploring Perivascular spaces in Alzheimer's disease using an automated Frangi filter technique

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: College Station

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: PROJECT NARRATIVE Increased levels of ceramides, bioactive sphingolipids in the brain, are associated with memory deficits in Alzheimer’s disease and in people with advanced age. Using the state-of-the-art lipidomics and novel genetically engineered mice where ceramide metabolism is targeted in a cell type specific manner, this project aims to understand the cellular and molecular basis of abnormal ceramide production in the brain and how it contributes to neurodegeneration and inflammation.

PI_NAMEs: LI, JIANRONG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta deposition;acid sphingomyelinase;Age;age related;age related neurodegeneration;Age-associated memory impairment;age-related disease;Aging;aging hippocampus;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;amyloid pathology;Amyloidosis;Anabolism;Animal Model;Area;Astrocytes;Automobile Driving;Brain;Brain region;Carbon;Cell Aging;Cell Communication;Cell Death;cell injury;Cell Lineage;Cell Physiology;cell type;Cells;Ceramides;Cognition;Cognitive deficits;conditional knockout;conditional mutant;cytokine;Data;Demyelinations;Deposition;Deterioration;Development;dihydroceramide desaturase;Disease;Disease Progression;Elderly;Etiology;extracellular;Foundations;Functional disorder;genetic manipulation;Genetically Engineered Mouse;glial activation;Goals;Hippocampus;Homeostasis;Human;Hydrolysis;immune activation;Impaired cognition;In Situ;in vivo;Individual;Inflammasome;Inflammation;Inflammatory;insight;Intervention;knock-down;Late Onset Alzheimer Disease;lipid metabolism;lipidomics;Lipids;Lysosomes;Mediating;Memory impairment;Metabolism;Microglia;Molecular;mouse model;Multiple Sclerosis;Mus;Mutant Strains Mice;Myelin;Myelin Sheath;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurons;non-demented;non-genetic;novel;old mice;oligodendrocyte lineage;Oligodendroglia;Onset of illness;paracrine;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Persons;Physiological;Play;Predisposition;prevent;Process;Production;Regulation;Research;Risk;Risk Factors;risk variant;Role;Signal Transduction;Sphingolipids;Sphingomyelinase;Sphingomyelins;Testing;Thinness;Time;TNF gene;transcriptomics;Up-Regulation;white matter

PROJECT_TITLE: Role of glial sphingolipid ceramide in aging and Alzheimer's disease

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE Informal caregiving for persons with dementia (PWD) who are living at home typically involve multiple caregivers, but little is known about the full scope of caregiving experienced by the many family members and/or friends involved in caregiving for PWD in the community. The proposed research will for the first time characterize informal caregiving networks of PWD longitudinally and generate evidence on how the network characteristics affect caregivers and PWD outcomes to help identify strategies for alleviating caregiver burden.

PI_NAMEs: SONG, MI-KYUNG  (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Activities of Daily Living;Adult;Affect;Aging;Alzheimer's disease related dementia;American;Black race;care burden;care giving burden;Caregiver Burden;Caregivers;caregiving;caregiving research;Caring;Characteristics;Collaborations;Communities;Complex;Consumption;Data;Decision Making;Dementia;Dementia caregivers;demographics;density;disability;Emergency department visit;Ensure;Evidence based program;experience;Family;Family Caregiver;Family member;Financial Hardship;First Degree Relative;Frequencies;Friends;Goals;Health;health management;Home;Hospitalization;Hour;human old age (65+);Impaired cognition;improved;indexing;Individual;informal caregiver;informal caregiving;informant;Literature;Living Arrangement;Long-Term Care;Maps;Mediating;member;Mental Depression;Monitor;older adult;Older Population;Outcome;Personal Satisfaction;Persons;Pharmaceutical Preparations;physical conditioning;Population;primary caregiver;Property;Proxy;psychosocial;Quality of life;Race;Reporting;Research;Residential Treatment;Resource Sharing;response;Rewards;Role;Sampling;Self Care;social group;Social Interaction;Social Network;social vulnerability;Societies;socioeconomics;Subgroup;Testing;Time;Vertebral column

PROJECT_TITLE: Informal Caregiving Networks of Older Adults with Dementia

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Immunotherapy;Infectious Diseases;Organ Transplantation;Precision Medicine;Sepsis;Transplantation

PHR: Project Narrative Bacterial bloodstream infections (BSI) are among the most common and serious infections in solid organ transplant (SOT) recipients. Optimal immunosuppression management in SOT recipients with BSI is unknown but critical to improving outcomes. The proposed studies will identify cytokine, chemokine, immunoglobulin, and gene expression biomarkers of 30-day mortality and septic shock among SOT patients with BSI, enabling the development of an immunologic prognostic model.

PI_NAMEs: EICHENBERGER, EMILY M. (contact)

PROJECT_TERMS: adverse outcome;Advocate;Affect;Bacteremia;Bacterial Infections;Bayesian Modeling;Big Data Methods;biobank;Biological;Biological Markers;biomarker identification;Biomedical Research;biosignature;career;Case/Control Studies;Cause of Death;CCL2 gene;chemokine;Clinical;Clinical Data;Clinical Management;clinical predictors;combat;CXCL10 gene;CXCR3 gene;cytokine;Data;Death Rate;Dedications;Development;Environment;Exhibits;experience;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Markers;Goals;Graft Rejection;Home;Hospitalization;IL8 gene;Immune;Immune response;Immunocompetent;Immunocompromised Host;Immunoglobulin G;Immunoglobulins;Immunologic Markers;Immunologics;immunomodulatory therapies;immunoregulation;Immunosuppression;improved outcome;Incidence;Infection;infection risk;Inflammatory;Inflammatory Response;Infrastructure;insight;Institution;Interferons;Interleukin-10;Interleukin-12;Interleukin-15;Interleukin-2;Interleukin-6;Literature;Machine Learning;Maintenance;Measures;Medical center;medical schools;Mentors;Mentorship;Methods;mortality;next generation;novel;organ transplant recipient;Organ Transplantation;Outcome;outcome prediction;Pathway interactions;Patients;Peripheral;peripheral blood;Physicians;Play;Population;Positioning Attribute;predictive modeling;predictive signature;prevent;prognostic;prognostic model;prognostication;prospective;Publishing;Recommendation;Research;Resources;Risk;Risk Factors;RNA;Role;Sampling;Scientist;Sepsis;Septic Shock;Serum;Severities;Solid;Specimen;success;Techniques;Testing;Tissue-Specific Gene Expression;TNF gene;Training;transcriptome sequencing;transplant centers;Transplantation;Transplantation Immunology;treatment strategy;United States National Institutes of Health;Universities;University Hospitals;Whole Blood

PROJECT_TITLE: Immune biomarkers to predict outcomes in solid organ transplant patients with bloodstream infections


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Aggression is often considered a “negative” behavior, but proper display of aggression is essential for self- preservation and maintenance of resources. The negative context of aggression has limited its study as a motivated behavior, yet it is critical to understand the adaptive as well as the maladaptive consequences of aggression in both sexes, in order to appreciate the underlying neurobiology and improve mental health outcomes. This proposal will advance our understanding of synaptic plasticity driving aggression reward and motivation, including the roles of glutamate and oxytocin.

PI_NAMEs: BORLAND, JOHNATHAN  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Aggressive behavior;Automobile Driving;Bathing;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral plasticity;Brain;Calcium;Calcium Signaling;career;Cells;clinical translation;combat;conditioned place preference;Custom;Dendritic Spines;density;design;Development;Electric Stimulation;Electrophysiology (science);experience;Female;Fiber;Glutamate Receptor;Glutamates;Goals;graduate school;Home;Hormones;Hypothalamic structure;Image;improved;in vivo;Lead;Learning;Love;Maintenance;male;Measures;Mediating;Mediator;Mental disorders;Mental Health;Mentors;Mentorship;Mesocricetus auratus;Modeling;motivated behavior;Motivation;Nature;neurobiological mechanism;Neurobiology;neuromechanism;neuron component;Neurons;novel;Nucleus Accumbens;optogenetics;Outcome;Oxytocin;paraventricular nucleus;patch clamp;Pathway interactions;Phase;Photometry;Physiological;Physiology;Postdoctoral Fellow;preference;Prefrontal Cortex;preservation;programs;Property;Publishing;receptor expression;Research;research facility;Research Personnel;Resources;Rewards;Role;role model;Running;sex;Sex Differences;skill acquisition;skills;Slice;social;Social Interaction;Source;Synapses;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;transmission process;women versus men

PROJECT_TITLE: Synaptic plasticity underlying sex differences in aggression reward

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (05)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This research project investigates the link between cerebral microvascular health and brain function in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients. CADASIL is the most common heritable cause of vascular dementia. Collectively, this project will provide fundamental knowledge about small vessel disease in humans and help to elucidate the link between cerebral microvascular health and clinical, functional, and cognitive impairments associated with small vessel disease.

PI_NAMEs: BARNES, JILL NICOLE (contact);LU, HANZHANG ;PAULSEN, JANE S

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Adult;Age;Alzheimer's disease related dementia;American;Arterial Disorder;autosome;Biological Markers;Blood Vessels;Brain;candidate marker;Carbon Dioxide;Cerebral small vessel disease;cerebrovascular health;cerebrovascular reactivity;Cerebrum;Clinical;Cognitive;cohort;Data;Data Collection;Development;Disease;Frequencies;functional decline;Functional disorder;Functional impairment;Funding;Gene Mutation;Genetic;Health;Heritability;Human;Impaired cognition;Impairment;Knowledge;Lacunar Infarctions;Life Cycle Stages;lifestyle factors;Light;Link;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Mental Depression;Microvascular Dysfunction;Migraine;Modeling;modifiable lifestyle factors;Motor Skills;Mutation;mutation carrier;National Institute of Neurological Disorders and Stroke;neurofilament;neuroimaging;Neuropsychology;NOTCH3 gene;novel;Participant;Pathogenesis;Patients;Pericytes;Phenotype;phenotypic biomarker;Physiological;preclinical study;primary outcome;Process;Rare Diseases;rate of change;Recommendation;Research Project Grants;response;Role;Seizures;Sensitivity and Specificity;Severities;Severity of illness;sex;Site;Smooth Muscle Myocytes;Source;Stimulus;Stroke;Subcortical Infarctions;Subcortical Leukoencephalopathy;Symptoms;Transient Ischemic Attack;trial readiness;United States National Institutes of Health;Validation;Variant;vascular cognitive impairment and dementia;Vascular Dementia;Vascular Smooth Muscle;white matter;white matter change;White Matter Hyperintensity;Work

PROJECT_TITLE: Cerebrovascular reactivity as a VCID biomarker in CADASIL

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: More than 42,000 persons with spinal cord injury (SCI) are eligible for treatment in the VA Healthcare System, with direct healthcare expenditures exceeding $716 million/year. Skeletal muscle fibrosis is a pathologic and currently unresolvable consequence of SCI. Fibrosis worsens muscle force producing capacity and promotes contractures, thereby facilitating limb impairment and hindering physical rehabilitation efforts. There is no known treatment for SCI-induced muscle fibrosis because a major gap exists in understanding of the cellular and molecular signals that stimulate fibrosis after SCI. As such, significant need exists to identify these signals and to test therapeutic strategies that target muscle fibrosis in the impaired limbs after SCI.

PI_NAMEs: OTZEL, DANA M (contact)

PROJECT_TERMS: Affect;Area;Atrophic;Attenuated;Behavior;Cell Separation;Cells;Chronic;Clinic;Clinical Trials;clinically relevant;Collagen;Contracture;crosslink;Data;Deposition;Development;Dose;Early identification;effective therapy;Eligibility Determination;Enzymes;Exhibits;Extracellular Matrix;Fibroblasts;Fibrosis;Future;Gene Expression;Generations;Genes;Genetic;Goals;Health Expenditures;Healthcare Systems;Heart;high risk;Hindlimb;Impairment;improved;In Situ;Infiltration;inhibitor;innovation;Intervention;Kidney;Knowledge;Limb structure;Liver;Locomotor Recovery;Lung;mechanical force;Modeling;Molecular;mRNA Expression;Muscle;Muscle Development;Muscle function;muscle regeneration;Muscular Dystrophies;Myofibroblast;Nerve;Nicotinamide adenine dinucleotide;Oral;Organ;Outcome;Oxidases;Pathologic;Pathway interactions;Perfusion;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphoric Monoester Hydrolases;Physical Rehabilitation;prevent;Production;progenitor;protein expression;Proteins;Rattus;Reactive Oxygen Species;Recovery;Recovery of Function;Rehabilitation therapy;response;Role;sham surgery;Signal Transduction;Skeletal Muscle;small molecule;Soleus Muscle;Spinal Cord Contusions;Spinal cord injury;Spinal cord injury patients;Testing;Therapeutic;therapeutic evaluation;Tissues;transcriptome sequencing;Translating;Translations;treatment strategy;Veterans;Yarrow

PROJECT_TITLE: Influence of NOX4 activity on muscle fibrosis after spinal cord injury


ORG_CITY: TUCSON

ORG_NAME: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: NARRATIVE  The number of patients with non-alcoholic steatohepatitis (NASH) in the United States will continue to escalate due to the high prevalence of the two main risk factors for the disease—obesity and diabetes that are both higher within the Veteran community compared to the general public. From a public health standpoint, there are no effective medications to treat NASH, no biomarkers for disease progression, and no effective high- throughput screening technologies. The goal of the project is to benchmark the in vitro microfluidic system against two animal models of NASH. The technology has unique advantages afforded by its ability to be a high- throughput system that utilizes patient-specific cells that can be obtained with minimal intervention. Once validated here, the microfluidic system will enable improved diagnostics, uncover molecular pathways and identify new treatments for a disease that leads to liver cancer, need for transplantation, and oftentimes death.

PI_NAMEs: WERTHEIM, JASON A (contact)

PROJECT_TERMS: Animal Disease Models;Animal Model;Animals;Award;Benchmarking;Biological Markers;biomarker identification;Biomedical Engineering;Biomimetics;Blood;Blood Coagulation Disorders;C57BL/6 Mouse;cell type;Cells;Cessation of life;Characteristics;cholangiocyte;Cirrhosis;Clinical;Communities;Data Set;Diabetes Mellitus;Diagnostic;Diet;Disease;disease model;Disease Progression;drug candidate;Drug Screening;Dyslipidemias;Endothelial Cells;Endothelium;Epithelium;experience;Extracellular Matrix;Fatty acid glycerol esters;fatty liver disease;Gene Expression;General Population;Genetic;genetic makeup;Goals;Grant;Guidelines;Healthcare;Hemorrhage;Hepatocyte;Hepatology;High Fat Diet;High Prevalence;high throughput screening;Histology;Human;human disease;human induced pluripotent stem cells;human model;Hypertension;Immune;improved;In Vitro;in vitro Model;Inbred NOD Mice;induced pluripotent stem cell;Intervention;Investigation;Kupffer Cells;lipid metabolism;lipidomics;Liver;liver biopsy;Liver diseases;Liver Dysfunction;Liver Failure;Liver Function Tests;Liver Stem Cell;liver transplantation;Malignant neoplasm of liver;Measures;Medical;member;Metabolic syndrome;metabolomics;Microfluidic Microchips;microfluidic technology;Microfluidics;military veteran;Modeling;Molecular;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;organ on a chip;Organoids;Pain;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;pluripotent stem cell differentiation;Population;precision drugs;Primary carcinoma of the liver cells;Productivity;programs;protein expression;protein metabolism;Public Health;Publishing;Reproducibility;Research;response;Risk;Risk Factors;Signal Transduction;stellate cell;System;Technology;Thrombocytopenia;Tissue Engineering;tissue/cell culture;Tissues;trait;transcriptomics;Transplantation;Transplantation Surgery;United States;United States National Institutes of Health;Validation;Veterans

PROJECT_TITLE: Validation of Patient-Specific, iPSC-based In Vitro Liver System

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 GAST-L (01)]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE We identified MLLT3 as a critical human HSC “stemness” regulator that dictates HSC fate decisions using distinct isoforms. Both long and short isoforms of MLLT3 are highly enriched in human HSCs but become downregulated in cultured HSCs, compromising their self-renewal and engraftment. Here we will use cutting edge molecular approaches to examine the mechanisms by which MLLT3 isoforms regulate human HSC functional maturation and ability to provide sustained multilineage engratfment, which may help develop new approaches to generating HSCs for the treatment of blood diseases.

PI_NAMEs: MIKKOLA, HANNA KATRI ANNIKKI (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: AF-9 protein;Alternative Splicing;Anabolism;Binding;Biology;blood treatment;Cell Culture Techniques;Cell Line;Cell Maturation;Cell Ontogeny;Cell Physiology;Cells;Cellular Assay;ChIP-seq;Chromatin;Clinical;cohesin;Complex;Cord Blood Hematopoietic stem cells;Data;Development;Elements;Embryo;Engraftment;Enhancers;Epigenetic Process;Equilibrium;Exons;fetal;Fetal Liver;gain of function;Generations;Genetic Transcription;Growth;Hematological Disease;Hematopoietic;hematopoietic stem cell differentiation;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hemogenic endothelium;Homeostasis;Human;Immunodeficient Mouse;Immunologics;Immunophenotyping;knock-down;leukemia;Life;Link;loss of function;Maintenance;Maps;Minority;Mitochondria;mitochondrial metabolism;MLLT3 gene;Molecular;multiple omics;nanopore;novel;novel strategies;overexpression;Oxidative Phosphorylation;Parents;Patients;Physiological;premature;prevent;programs;Protein Isoforms;protein protein interaction;Protein Truncation;Proteins;Regulation;Regulator Genes;Regulatory Element;Repression;self-renewal;single-cell RNA sequencing;Stem Cell Development;stem cell function;stemness;success;Transcript;transcriptome sequencing;Translations;Umbilical Cord Blood;Undifferentiated;Variant

PROJECT_TITLE: REGULATION OF HUMAN HEMATOPOIETIC STEM CELL FATE VIA MLLT3 ISOFORMS

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Lewy Body Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Parkinson's Disease;Sleep Research

PHR: Project Narrative Lewy body dementia is the second most common neurodegenerative dementia following Alzheimer disease and imposes significant human and economic costs. Loss of synapses, or chemical connections between nerve cells in the brain, is thought to be a major mechanism by which these dementias cause symptoms. For this project, we will study volunteers who are at risk for Lewy body dementia using simultaneous magnetic resonance imaging and positron emission tomography to quantify the density of synapses in their brains relative to other measures of brain health, thus providing a temporal map of brain changes for use in future intervention trials.

PI_NAMEs: GALLAGHER, CATHERINE L. (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Age;Aging;aging population;alpha synuclein;Alzheimer's Disease;Alzheimer's disease pathology;Attention;Autopsy;behavior change;Biological Markers;Brain;brain health;Brain imaging;Brain Mapping;Cells;Central Nervous System;Cerebral cortex;Chemicals;Clinical;Cognition;Cognitive;cognitive change;cognitive function;cohort;Constipation;Data;Delusions;Dementia;Dementia with Lewy Bodies;density;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Dose;Dysautonomias;economic cost;Education;Evaluation;Event;executive function;experience;follow-up;Future;Goals;healthy aging;Hippocampus;Human;Image;Impaired cognition;Impairment;in vivo;Individual;innovation;Intervention Trial;Language;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Lewy neurites;Magnetic Resonance Imaging;Maps;Measures;Medial;Memory;mild cognitive impairment;Modeling;Moods;Motor;Movement;Neocortex;Nerve Degeneration;Neurites;neurodegenerative dementia;neuroimaging;Neurons;Neuropsychology;novel;Onset of illness;Orthostatic Hypotension;Paranoia;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;Participant;Pathologic;Patients;Peripheral Nervous System;Persons;Physics;Polysomnography;Population;Positron-Emission Tomography;pre-clinical;programs;protein aggregation;Proteins;Psychoses;Radiopharmaceuticals;rate of change;recruit;REM Sleep Behavior Disorder;Research;Resolution;response;Risk;Risk Factors;Role;sex;Smell Perception;Specific qualifier value;Standardization;structural imaging;Structure;Substantia nigra structure;Symptoms;Synapses;synucleinopathy;Temporal Lobe;theories;Therapeutic Intervention;Thick;Tremor;Visual Hallucination;Visuospatial;volunteer;white matter;Work

PROJECT_TITLE: Mapping Synaptic Density in Prodromal and Manifest Lewy Body Dementia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: BOSTON

PHR: NARRATIVE The goal of this project is to construct biomarkers for risk of dementia using multiple novel EEG measures and deep learning techniques. Using the existing large datasets of >8,000 subjects from four longitudinal cohort studies, the project will also test whether the constructed biomarkers mediate or moderate the genetic influence on the risk for dementia and can facilitate a better prediction of future cognitive decline and other adverse health outcomes. This project will potentially provide a non-invasive, cost-efficient tool that can be used to identify people at risk for developing dementia and to evaluate the treatments/interventions of the disease.

PI_NAMEs: HAGHAYEGH, SHAHAB  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: abeta deposition;Address;Adult;Advisory Committees;age effect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Artificial Intelligence;Award;Biological Markers;Biomedical Engineering;Biometry;Brain;Brain region;circadian;Circadian Dysregulation;circadian pacemaker;Clinical;Clinical Research;Cognition;Cognitive;cognitive change;cohort;Complex;convolutional neural network;cost efficient;Coupling;Data;data harmonization;Data Science;Data Set;deep learning;Dementia;dementia risk;Dependence;Diagnosis;disability;disability risk;Disease;effective therapy;Electroencephalography;Epilepsy;Ethnic Origin;Evaluation;follow-up;Fourier Transform;Fractals;Frequencies;functional outcomes;Future;Genes;Genetic;genetic analysis;Genetic Risk;Goals;Health;Hospitals;Human;Impaired cognition;improved;Individual;Interdisciplinary Study;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Intervention;large datasets;Learning;Link;Longitudinal cohort study;Measures;Mediating;medical schools;Medicine;Mentors;Methods;mild cognitive impairment;Modeling;Monitor;Nerve Degeneration;network models;Neural Network Simulation;Neurobehavioral Manifestations;Neurons;Nonlinear Dynamics;novel;older adult;Older Population;Outcome;Pathologic;Pattern;Performance;Phase;Phenotype;Physiological;Physiology;polygenic risk score;Populations at Risk;pre-clinical;predictive tools;prevent;prognostic value;programs;Research;Research Activity;Research Project Grants;Resources;Risk;risk prediction;sex;Signal Transduction;Single Nucleotide Polymorphism;Sleep;Sleep Stages;Techniques;Testing;theories;Time;tool;Training;Training Activity;Woman

PROJECT_TITLE: Prediction of dementia in older adults using nonlinear EEG features

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Urologic Diseases

ORG_CITY: ORANGEBURG

ORG_DEPT: BIOLOGY

ORG_NAME: SOUTH CAROLINA STATE UNIVERSITY

PHR: Although prostate cancer deaths have declined in the United States over the past decade, it is still the second leading cause of cancer death in males. Developing a method to increase phagocytic uptake of tumor cells could greatly improve mortality rates and racial disparities associated with prostate cancer. The goal of this work is to evaluate the role of acetylation on concentration of a surface exposed damage associated molecular pattern.

PI_NAMEs: THOMAS, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: WALI, ANIL

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Advisory Committees;American;androgen sensitive;Androgens;Binding;Binding Proteins;biobank;Biological Assay;Black race;calreticulin;cancer cell;cancer diagnosis;Cancer Etiology;cancer health disparity;Cancer Patient;cancer type;Cancerous;career;career development;Cell Differentiation process;Cell Line;Cell surface;cell type;Cells;Cessation of life;Cloning Vectors;cohort;Coumarins;Data;Death Rate;Dependence;design;disorder control;Down-Regulation;DU145;Eating;Endoplasmic Reticulum;Environment;Epithelial Cells;Epithelium;Gleason Grade for Prostate Cancer;Goals;Hispanic;Immune signaling;Immune system;improved;Incidence;Knowledge;Ligand Binding;LNCaP;Location;Lysine;male;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Mentors;Methods;migration;Molecular;Molecular Biology;Molecular Chaperones;Monitor;Mutate;Mutation;neoplastic cell;Not Hispanic or Latino;Outcome;Pathologist;Patient-Focused Outcomes;Patients;Pattern;PC3 cell line;Phagocytes;Phagocytosis;Post-Translational Protein Processing;Process;programs;Prostate;prostate cancer cell;prostate cancer cell line;Prostatic Epithelium;Protein Isoforms;protein structure;Protein translocation;Proteins;Proteome;Proteomics;Protocols documentation;Qualifying;Race;racial disparity;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Restriction Mapping;Role;Scientist;Severities;Signal Transduction;Site;skills;South Carolina;Stains;Stromal Cells;Structure;Surface;Surface of the Prostate;Testing;therapeutic target;Tissue Sample;Tissues;tool;trafficking;Training;tumor microenvironment;Tumor stage;undergraduate research;undergraduate student;United States;Universities;Up-Regulation;uptake;Work

PROJECT_TITLE: Role of Calreticulin Acetylation on Trafficking in Prostate Cancer


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Lung;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Sleep Research

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is becoming the most common neurodegenerative disorder among adults, a population that is projected to grow exponentially in the coming decades. A growing body of research demonstrates that modifiable lifestyle factors are key to understanding the progression of AD from midlife – when the nascent pathologic processes underlying AD begin – to later life. This project will evaluate the associations of midlife aerobic fitness and sleep apnea with increased risk of AD pathology and dementia, making critical advances toward the early identification and potential prevention of AD.

PI_NAMEs: OKONKWO, OZIOMA C (contact);PEPPARD, PAUL E

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;Adult;Aerobic Exercise;Age;Age of Onset;aged;Aging;aging population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid;Amyloid beta-Protein;apolipoprotein E-4;Attenuated;Biological Assay;Biological Markers;Brain;cardiorespiratory fitness;Chronic;Clinical;Cognition;Cognitive;cognitive process;cohort;Cohort Studies;Collection;Data;Dementia;Dependence;design;disability;Disease;Disease Outcome;Early identification;Epidemic;fitness;Functional disorder;Glial Fibrillary Acidic Protein;Health;health data;Hippocampus;human old age (65+);Image;Impaired cognition;improved;Incidence;Individual;innovation;interest;Investigation;late life;lifestyle factors;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;Methods;middle age;mild cognitive impairment;modifiable lifestyle factors;modifiable risk;Modification;Neurocognition;Neurocognitive;Neurodegenerative Disorders;novel;Obstructive Sleep Apnea;older adult;Onset of illness;Participant;participant retention;Pathologic Processes;Pattern;Phenotype;Physical activity;physical conditioning;Plasma;Play;Population;Positioning Attribute;Positron-Emission Tomography;pre-clinical;prevent;Prevention;prospective;protective factors;Public Health;Recording of previous events;Reporting;Research;resilience factor;Risk;Risk Factors;Role;Running;Sampling;Senile Plaques;Severities;sex;sex as a biological variable;Sleep;Sleep Apnea Syndromes;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;sociodemographics;stem;Symptoms;tau Proteins;tau-1;Therapeutic;Time;Transducers;white matter;Wisconsin;Woman;Work

PROJECT_TITLE: Sleep and Aerobic Fitness as Midlife Modifiers of Later Life Cognitive Decline and Alzheimer's Disease Biomarkers in the Wisconsin Sleep Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-D (02)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Heart Disease;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The disease course of chronic heart failure, a prevalent disease with high morbidity and mortality, is highly variable and our ability to predict progression on an individual level and prevent it is limited. Data from animals suggests that the gut microbiome, a community of microbes living in our gastrointestinal tract, may play a role in heart failure pathophysiology and disease progression. The goal of this project is to better understand disturbances in the gut microbiome, its interactions with the host and their joint impact on heart failure pathophysiology and disease progression in patients with chronic heart failure, which will identify novel preventative and therapeutic targets and improve risk stratification in this disease.

PI_NAMEs: MAMIC, PETRA  (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: Adult;Affect;animal data;Anti-Inflammatory Agents;Applied Skills;Award;Bacteria;Bifidobacterium;Biological Markers;Biology;Blood specimen;Blood Vessels;Cardiac;career;career development;chemokine;Clinical;Clinical Data;Clinical Research;Clinical Trials;cohort;Communication;Congestive Heart Failure;CXCL10 gene;CXCR3 gene;cytokine;Data;Data Analyses;Data Set;Dependence;Development;Dietary Fiber;Dietary Intervention;Disease;Disease Progression;disorder risk;Double-Blind Method;Echocardiography;Enrollment;Environment;Fasting;Fermentation;Functional disorder;functional status;Funding;Future;Gastrointestinal tract structure;Goals;Gram-Positive Bacteria;gut dysbiosis;gut microbes;gut microbiome;Heart failure;heart failure with reduced ejection fraction;Heterogeneity;host microbiome;Human;Immune;Immune response;improved;improved outcome;Individual;inflammatory marker;insight;Intervention;Investigation;Joints;Knowledge;Lead;Leadership;Mediating;member;Mentors;Mentorship;metabolomics;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;microbial community;microbiome;microbiome analysis;microbiome composition;microbiome research;Modality;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;National Heart, Lung, and Blood Institute;new therapeutic target;novel;novel marker;Nutrient;Outcome;Outcomes Research;Participant;Pathway interactions;Patient Care;Patients;Pattern;Pharmaceutical Preparations;Physicians;Physiology;post intervention;precision medicine;prevent;primary endpoint;probiotic supplementation;Probiotics;prognostication;programs;prospective;Publishing;randomized placebo controlled study;recruit;Regulation;Research;Research Methodology;Research Personnel;Research Proposals;risk stratification;Role;Running;Scientist;secondary endpoint;Severities;skill acquisition;stool sample;Structure;Therapeutic;therapeutic target;Time;Time Series Analysis;Translating;Translational Research;treatment response;Variant;Volatile Fatty Acids;Work

PROJECT_TITLE: The Role of the Bifidobacterium Gut Microbiome Guild in Pathophysiology of Chronic Heart Failure with Reduced Ejection Fraction

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Alzheimer’s disease (AD) is a major public health crisis. The goal of this project is to leverage the electronic Self-Administered Gerocognitive Examination (eSAGE), the metadata collected during eSAGE test-taking, the rich electronic health record data, and advanced machine learning techniques to develop a widely accessible, easy-to-use, and highly accurate assessment tool, its smart app and its integration with EHR systems for cognitive impairment detection. The tool will be evaluated and validated by socioeconomic disadvantaged, AD- vulnerable populations.

PI_NAMEs: NING, XIA  (contact);SCHARRE, DOUGLAS W

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease diagnosis;American;Assessment tool;Attention;Behavioral;Black Populations;case finding;Characteristics;Clinic;Clinical;Clinical Data;Cognitive;cognitive capacity;cognitive skill;cognitive testing;cost;Data;data modalities;Dementia;Detection;Disadvantaged;Disparity;E-learning;Early Diagnosis;effective therapy;Electronic Health Record;electronic health record system;Electronics;ethnic minority population;explainable machine learning;generative adversarial network;Goals;health care availability;Health Care Costs;health disparity;Healthcare;Hispanic Populations;human old age (65+);Impaired cognition;improved;Individual;innovation;Knowledge;Learning;Machine Learning;machine learning method;Medical center;Memory Disorders;Metadata;mild cognitive impairment;Minority Groups;Monitor;novel;Ohio;Outcome;outreach;payment;personalized predictions;Population;Prevalence;Public Health;racial minority population;Research;Resource-limited setting;Resources;Rural Population;rural underserved;Self Administration;Series;social health determinants;socioeconomic disadvantage;Stress;synergism;Techniques;telehealth;Testing;Time;tool;Translating;translational impact;Underserved Population;Vulnerable Populations

PROJECT_TITLE: Integrating eSAGE with EHR data using machine learning for the early detection and monitoring of cognitive impairment in individuals including those underserved

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Immunization;Neurodegenerative;Neurosciences

PHR: Antibodies are critical components of the immune system that direct inflammation and other immune responses through interactions with receptors, which are controlled in large part by conserved sugar, or glycan, molecules on the antibody. Proinflammatory changes in antibody glycosylation have been shown to correlate with Alzheimer’s Disease and may be a predictive biomarker of disease onset and/or severity. We have developed a novel method for comprehensive profiling the glycosylation states of antibodies that we will use to decipher the glycosylation code of Alzheimer’s Disease.

PI_NAMEs: ROBERTS, BLAINE RUSSELL;SUNDBERG, ERIC JOHN (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Adaptive Immune System;Address;Affinity;Age;Alzheimer's Disease;Alzheimer's disease patient;Amino Acid Sequence;Amyloid;Antibodies;Antibody Therapy;Binding;Blood;Brain;Cell Culture Techniques;Cells;Cerebrospinal Fluid;Chemical Structure;Chemicals;Code;cohort;Complement 1q;Disease;Dissociation;Electrons;Exhibits;Fab domain;Fc domain;Fc Receptor;Gender;genetic variant;Glycopeptides;Glycoproteins;glycosylated IgG;glycosylation;Human;IgG Receptors;IgG1;IgG2;IgG3;IgG4;Image;Immune response;Immune system;Immunoglobulin Constant Region;Immunoglobulin G;Immunoglobulins;Immunologic Stimulation;Immunologics;Impaired cognition;Individual;individual patient;Inflammation;Inflammatory;inflammatory marker;innovation;Ions;Light;Link;liquid chromatography mass spectroscopy;longitudinal analysis;Mass Spectrum Analysis;Measurement;Measures;Mediating;Methods;Molecular;Monitor;Monoclonal Antibodies;novel;Onset of illness;Patients;Peptides;Plasma;Polysaccharides;predictive marker;Preparation;Property;Proteins;Protomer;Race;receptor;receptor binding;recruit;Research;Sampling;Serum;Severity of illness;side effect;Signal Transduction;sugar;Techniques;Technology;Time;tool;two-dimensional;Vaccines;Work

PROJECT_TITLE: Deciphering the IgG glycosylation code of Alzheimer's Disease

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The UCSD PRIDE Future Faculty Cardiovascular Sciences (FOCUS) program will successfully mentor underrepresented early career faculty and transitioning postdoctoral fellows and develop sustainable skills to enhance their research progress and success in obtaining NIH or equivalent funding. The overall goal of the FOCUS is to improve the diversity of the biomedical workforce.

PI_NAMEs: ROSS, ROBERT SCOTT;TREJO, JOANN  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: academic preparation;Academic skills;academic standard;African American population;American;American Heart Association;Applications Grants;Area;Award;Basic Science;Biomedical Research;California;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;career development;Career Mobility;career networking;Caring;Categories;Censuses;Child;Client satisfaction;Clinical Research;cohort;Communication;Data;design;Development;Diagnosis;disabled;disadvantaged background;Disparity;early-career faculty;Education;ethnic minority population;Ethnic Origin;evidence base;Extramural Activities;Faculty;faculty mentor;Fellowship Program;Fostering;Frequencies;Funding;Future Teacher;Goals;Grant;Health;health care disparity;Healthcare;High Prevalence;Hispanic Americans;Home;Hypertension;improved;Individual;innovation;Institution;Insurance;journal article;K-Series Research Career Programs;Knowledge;Leadership;Manuscripts;medical schools;member;Mentors;Mentorship;Minority Groups;Modeling;Native Americans;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Participant;Patients;Physicians;Population;Postdoctoral Fellow;Prevalence;primary care provider;Principal Investigator;Process;Productivity;programs;Race;racial minority population;Recording of previous events;recruit;Reduce health disparities;Research;research and development;Research Personnel;Science;Self Efficacy;skills;success;summer institute;Surgeon;System;Testing;Training;Training Programs;Translational Research;Underrepresented Populations;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: UCSD Future Faculty of Cardiovascular Sciences (FOCUS)

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-G (O2)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project narrative Using a multidisciplinary approach, this proposal will investigate how brain feeding-driving neurons are the upstream of stress-responsive neurons to directly regulate stress responses. The expected findings from this proposal will have a significant impact on understanding the novel brain basis and mechanisms that underlie stress responses, and will provide novel insights on developing effective therapeutic strategy against an array of comorbidities of eating disorders and stress-related mental illnesses.

PI_NAMEs: XU, YUANZHONG  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: acute stress;Anatomy;Animals;Anxiety;Apical;ART protein;Automobile Driving;base;behavior test;Behavioral;behavioral outcome;behavioral response;biological adaptation to stress;Brain;Buffers;Circulation;comorbidity;Complex;coping;Corticotropin-Releasing Hormone;Cues;Data;Eating Disorders;effective therapy;Emotional;environmental stressor;Equilibrium;Exposure to;feeding;Feeding behaviors;Fiber;Food;gamma-Aminobutyric Acid;Genetic;genetic approach;Glutamates;Homeostasis;Hormonal;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;in vivo;in vivo calcium imaging;Induced Neurons;insight;interdisciplinary approach;Label;Mediating;Mental disorders;Modality;Modeling;Mus;neural;Neurons;neuroregulation;Neurotransmitters;novel;optogenetics;paraventricular nucleus;Phase;Photometry;Physiologic pulse;Pilot Projects;pilot test;Pituitary Gland;Play;Population;Post-Traumatic Stress Disorders;presynaptic;Pseudorabies;Public Health;Regulation;Reporter;response;restraint;Role;sensor;Shapes;Signal Transduction;Societies;Source;Stimulus;Stress;stressor;Structure of nucleus infundibularis hypothalami;Synapses;Testing;therapeutically effective;Time;Transgenic Organisms;Viral

PROJECT_TITLE: The direct regulation of feeding-driving hypothalamic GABAergic neurons on stress responses

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: INDIANAPOLIS

ORG_NAME: RLR VA MEDICAL CENTER

PHR: Multiple Myeloma is incurable cancer with increased prevalence among older Veterans, African Americans and those exposed to Agent Orange. Myeloma cells alter bone marrow to support their growth, causing non-healing bone damage. Current treatments do not heal bone lesions and drug resistance is common. Patients are on treatment lifelong, with new options needed at periodic relapses, putting a huge strain on the VA system. We propose to add the already approved non-cancer drug, fingolimod, to proteasome inhibitor the mainstay of myeloma treatment, to improve response and bone health. Deeper response is expected to lead to longer disease control and better quality of life. The combination will be tested in animal models of MM with effects on tumor burden and bone cells determined. Markers of response will be mapped in patients, and the combined treatment tested against patient bone marrow samples, with the goal of a rapid and efficient clinical trial within five years, which would lead to swift adoption of the combined treatment.

PI_NAMEs: SUVANNASANKHA, ATTAYA  (contact)

PROJECT_TERMS: Adjuvant;Adoption;Affect;African American population;agent orange;analog;Animal Model;antitumor effect;Biological Assay;bone;bone cell;Bone Formation Stimulation;bone healing;bone health;Bone Marrow;Bone Pain;Bortezomib;Cell Communication;Cell Line;Cell Separation;Cells;Chronic;Clinic;Clinical Trials;Coculture Techniques;Combined Modality Therapy;Data;design;Diagnosis;Disease remission;disorder control;Distant;Drug Modulation;Drug resistance;Elderly;Endocrine;Endothelial Cells;Exposure to;Family;FDA approved;Financial Hardship;Future;Generations;Genes;Genetic Markers;genetic risk factor;Goals;Grant;Growth;Gulf War;healing;Health;Hematopoietic Neoplasms;Human;human model;Immune system;Immunomodulators;improved;Incidence;Intravenous;Lesion;Maintenance Therapy;male;Malignant Neoplasms;Maps;Modeling;molecular sequence database;mouse model;Multiple Myeloma;Multiple Sclerosis;Mus;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;Oral;Osteoblasts;Osteoclasts;Osteogenesis;Osteolytic;Outcome;Patients;Periodicals;Pharmaceutical Preparations;Phase I/II Clinical Trial;pill;Plasmacytoma;pre-clinical;preservation;Prevalence;prevent;prospective;Proteasome Inhibitor;Quality of life;Recurrence;Refractory;Regimen;Relapse;response;response biomarker;Risk;Safety;Sampling;skeletal;Solid Neoplasm;Specificity;Sphingolipids;subcutaneous;substantia spongiosa;System;Testing;Tissue Banks;treatment response;trial planning;tumor;Tumor Burden;Validation;Vertebral column;Veterans;Vietnam;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Preclinical Validation of Adjuvant Fingolimod to Increase Efficacy of Proteasome Inhibitors for Treatment of Multiple Myeloma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDB-P (01)]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

ORG_CITY: FORT COLLINS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alzheimer’s disease is a condition in which neurons of the brain cannot remove damaged and dysfunctional proteins. This proposal will test whether increasing the ability of neurons to remove these proteins improves cellular health and cognition in mice. If successful, these studies will reveal a new target for the treatment and management of Alzheimer’s disease.

PI_NAMEs: LARK, DANIEL  (contact);LAROCCA, THOMAS

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Age;age related;aged;Aging;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;Atlases;Brain;brain cell;brain health;Cell membrane;Cells;Charge;Clinical;clinical development;Cognition;Cognitive;cognitive function;Complex;Data;Data Set;Defect;Dependovirus;Economic Burden;Elderly;Endosomes;exosome;experimental study;Foundations;Frontotemporal Dementia;Functional disorder;Future;Goals;Health;Human;Immunotherapy;Impaired cognition;Impairment;improved;In Vitro;in vivo;Kidney;life span;Mechanics;Membrane;Metabolism;Molecular;mouse model;Multivesicular Body;Mus;Neurodegenerative Disorders;neuroinflammation;Neurons;neuropathology;Parkinson Disease;Pathologic;Pathology;Patients;prevent;Prophylactic treatment;protein expression;Proteins;Research;secondary analysis;Sorting;synaptic function;tau aggregation;tau mutation;tau Proteins;Testing;therapeutic development;trafficking;transcriptomics;Transgenic Organisms;Treatment Efficacy;Wild Type Mouse

PROJECT_TITLE: Targeting age-related endosome dysfunction to treat cognitive decline and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Z (55)]