NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Clinical Research;Heart Disease;Prevention;Women's Health Research

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Doxorubicin (Adriamycin®) is a highly effective cancer treatment, but it causes heart toxicity in 10 to 20 percent of patients who receive it. This proposal seeks to understand how the heme-binding protein hemopexin could serve as a blood biomarker as well as a protective treatment for patients at risk of doxorubicin heart toxicity.

PI_NAMEs: ASNANI, AARTI  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Address;Adriamycin PFS;Affinity;Algorithms;Anthracycline;aptamer;Binding;biobank;Biodistribution;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;Brain;Breast Cancer therapy;Cancer Biology;cancer therapy;Cardiac;Cardiomyopathies;cardioprotection;Cardiotoxicity;Cardiovascular Diseases;Chemicals;chemotherapy;Chronic;Clinical;cohort;Collaborations;cost effective;Cytotoxic Chemotherapy;Data;Dedications;Diagnosis;Dose;Doxorubicin;Drug Metabolic Detoxication;early detection biomarkers;Echocardiography;effective therapy;Enzyme-Linked Immunosorbent Assay;Female;Genetic;Glycoproteins;Hand;Heart;Heart failure;heart function;Heart Injuries;Hematologic Neoplasms;Heme;heme oxygenase-1;heme-binding protein;Hemopexin;Human;Imaging Techniques;improved;Inflammation;Inflammatory;insight;Institution;Investigation;Iron;iron metabolism;Iron Overload;Israel;Kinetics;Knockout Mice;leukemia;Liver;loss of function;Lymphoma;Macrophage;male;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical center;medical schools;Metabolism;Molecular;mouse model;multidisciplinary;Mus;Myocardial dysfunction;Natriuretic Peptides;novel therapeutic intervention;Oncology;Oxidative Stress;Pathogenesis;Pathway interactions;patient population;Patients;Phenotype;Physiological;Pilot Projects;Plasma;Plasma Proteins;prevent;professor;Prognosis;Proteins;Proteomics;Reactive Oxygen Species;receptor mediated endocytosis;Recycling;response;Reticuloendothelial System;Risk;risk stratification;Rodent Model;Role;Sarcoma;screening;Spleen;Stress;Toxic effect;Treatment Protocols;trend;Troponin;Validation;Wild Type Mouse;Women's cohort;women's treatment;Work

PROJECT_TITLE: Hemopexin as an Early Biomarker of Anthracycline Cardiac Toxicity


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: BROOKLYN COLLEGE

ORG_STATE: NY

PHR: Project narrative Failure of proper cell cycle control results in chromosome instability which is a hallmark of tumorigenesis. It has been extensively studied how Cyclin Dependent Kinase (Cdk1) promotes cell cycle progression, but little is known how the Cdk1-dependent phosphorylation events are reversed by phosphatase. In this study, we identify and investigate targets of the PP2A phosphatase during cell cycle progression.

PI_NAMEs: IKUI, AMY E (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Affect;Binding;Biological Models;C-terminal;Cancer Patient;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell division;Cell model;Cell Physiology;Cell Proliferation;Cells;ChIP-seq;Chromosomal Instability;Chromosome Segregation;cohesin;Complex;Consensus;Cyclin-Dependent Kinases;Cyclins;daughter cell;Dissociation;DNA biosynthesis;Ensure;Equilibrium;Eukaryota;Eukaryotic Cell;Event;Extramural Activities;Failure;Gel;Genome;genome integrity;Goals;Homologous Gene;Human;inhibitor;Knowledge;Learning;Licensing;Malignant Neoplasms;Mitosis;Mitotic spindle;model organism;mutant;N-terminal;novel;novel anticancer drug;Pattern;Phase;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Process;Productivity;Protein Dephosphorylation;Protein phosphatase;Protein-Serine-Threonine Kinases;Proteins;PTTG1 gene;remediation;Replication Initiation;Research;Research Project Grants;Role;Saccharomyces cerevisiae;separase;Serine;Signal Transduction;Signal Transduction Pathway;Site;targeted agent;Testing;therapeutic target;Threonine;tumorigenesis;Yeasts

PROJECT_TITLE: A role of PP2A-Cdc55 in cell cycle


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Genome-wide association studies have identified many broad genomic regions associated with psychiatric disorders. The goal of this project is to pinpoint the causal DNA sequence in each disease-associated region and study the mechanism through which those sequences contribute to mental illness.

PI_NAMEs: LUO, CHONGYUAN  (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Adopted;Adult;Alleles;autism spectrum disorder;Biological Assay;Brain;brain cell;BRAIN initiative;Brain region;causal variant;Cell Line;Cell Nucleus;cell type;Cells;Censuses;Chromatin;Chromosome Mapping;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Coupled;CRISPR interference;CRISPR/Cas technology;Data Set;Disease;disorder risk;DNA Methylation;DNA methylation profiling;DNA Sequence;Enhancers;epigenomics;Etiology;experimental study;Gene Expression Regulation;Genes;Genetic;Genetic Engineering;genetic variant;genome wide association study;genome-wide;Genomic Segment;Goals;Hippocampus;Human;improved;Individual;insight;Joints;Link;Maps;Measurement;Mediating;Mental disorders;Methods;Methylation;Molecular;Molecular Conformation;multiple omics;nerve stem cell;neuropsychiatric disorder;novel;Phenotype;pleiotropism;polygenic risk score;Population;Probability;Property;Protein Isoforms;psychiatric genomics;Quantitative Trait Loci;Regulation;Regulatory Element;repaired;Resolution;Risk;risk variant;Schizophrenia;single nucleus RNA-sequencing;Statistical Methods;Structure;Technology;Testing;Tissues;trait;Transcription Alteration;Transcriptional Regulation;transcriptome;transcriptomics;Untranslated RNA;Variant

PROJECT_TITLE: SINGLE-CELL MULTI-OMIC APPROACHES TO MECHANISTICALLY CHARACTERIZE PSYCHIATRIC DISORDER RISK LOCI IN THE HUMAN BRAIN


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Clinical Research;Contraception/Reproduction;Genetics;Infertility;Prevention;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative: Chemotherapy-induced premature menopause and infertility are major sources of health problems. If the mechanisms of chemotherapy-induced oocyte death as well the pathways to repair and prevent such damage are understood, quality of life of cancer survivors can be greatly enhanced. The same knowledge would also enable us to moderate reproductive aging for all women and can also provide insights into the prevention of overall aging.

PI_NAMEs: OKTAY, KUTLUK H (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Acute;Affect;Age;Aging;analog;Apoptotic;ATM Signaling Pathway;Biological Assay;Biological Models;BRCA mutations;BRCA1 gene;BRCA2 gene;BRCA2 Mutation;Cancer Etiology;cancer therapy;Cells;Ceramides;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical Research;clinical translation;Code;cohort;Collaborations;comparison control;Complementary DNA;Confocal Microscopy;Coupled;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;Double Strand Break Repair;efficacy testing;experience;experimental study;FDA approved;Fertility;fertility preservation;Funding;Future;Gene Expression;Genes;Genotoxic Stress;genotoxicity;Germ Cells;gonad function;Grant;Growth;Health;high risk;Human;Immunohistochemistry;In Vitro;in vivo;Individual;Infertility;inhibitor;insight;Intervention;knock-down;Knowledge;Laboratories;Lasers;life span;Longitudinal Studies;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;member;Memorial Sloan-Kettering Cancer Center;Microinjections;Modeling;Molecular;Mus;Mutation;mutation carrier;novel;Oocytes;Ovarian;Ovarian aging;ovarian damage;Ovarian Follicle;ovarian reserve;Ovary;Pathway Analysis;Pathway interactions;pharmacologic;Pharmacological Treatment;Phase;Phosphorylation;Predisposition;Premature Menopause;preservation;prevent;Prevention;Primordial Follicle;Proteins;Public Health;quality of life for cancer survivors;Quantitative Reverse Transcriptase PCR;Registries;repaired;reproductive;reproductive outcome;reproductive senescence;RNA Interference;Role;Serum;Small Interfering RNA;Source;sphingosine 1-phosphate;Time;Tissues;transcriptome sequencing;translational study;Woman;women's diagnosis;Women's mortality;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Characterization and prevention of Chemotherapy-Induced Damage to Ovarian Reserve

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Hematology;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in individuals receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). Plasmacytoid dendritic cells (pDCs) are known potent suppressor of alloreactive T cell responses and can be potentially used to reduce GVHD. The proposed studies will investigate the role of Dot1l in regulating the dynamics of the interaction between pDCs and GVHD in the setting of allo-HSCT and the impact of pDCs on controlling GVHD.

PI_NAMEs: ZHANG, YI  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Adoptive Transfer;Allogenic;Allografting;Autoimmunity;Blood;Cancer Patient;Cell Therapy;Cells;Cellular Stress;Cessation of life;Clinic;Clinical;Complication;CSF3 gene;Data;Defect;Dendritic Cells;Development;Disease;disorder prevention;Epigenetic Process;FLT3 ligand;Functional disorder;Generations;graft versus host disease induction;graft vs host disease;Granulocyte-Macrophage Colony-Stimulating Factor;Hematologic Neoplasms;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Human;Immune;Immunity;Immunosuppression;Impairment;improved;in vivo;Individual;Infection;Inflammatory;Interferons;isoimmunity;Life;Maintenance;Malignant Neoplasms;Methods;Methylation;Modeling;Molecular;Morbidity - disease rate;mortality;Multipotent Stem Cells;Mus;novel;novel strategies;Oxidative Stress Induction;Pathway interactions;Patients;peripheral blood;Population;prevent;Production;progenitor;programmed cell death ligand 1;Proliferating;Property;reconstitution;Recovery;Regulation;Repression;Role;Signal Transduction;Specific qualifier value;stem cell differentiation;Stimulus;Suppressor-Effector T-Lymphocytes;System;T cell response;T-Cell Activation;T-Lymphocyte;Testing;transcription factor;Translating;translational potential;Transplant Recipients;Work

PROJECT_TITLE: DOT1L, reconstitution of plasmacytoid dendritic cells and alloimmunity

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer-related death in the United States and is in grave need of new therapeutic strategies. This proposal examines the intersection of the field of cancer neurogenesis and cancer immunology by studying the role of Spon1+ inflammatory monocytes on the progression of lung cancer. I incorporate in vitro and in vivo techniques to answer how nerves are recruited into tumors by inflammatory monocytes and to determine their role in lung cancer tumor progression and metastasis with a long term goal of providing patients with more effective treatment options.

PI_NAMEs: SENGOTTUVEL, NISITHA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Accounting;Adoptive Transfer;Axon;axon guidance;Biological Assay;Biology;Blood;Bone Marrow;cancer cell;Cancer Etiology;career;CCL2 gene;Cells;Cessation of life;checkpoint inhibition;chemokine;Coculture Techniques;Data;Development;Discipline;Disease Progression;Dissection;Distant;effective therapy;experimental study;Funding;Ganglia;genetic approach;Genetic Engineering;Goals;Growth;Human;Image;Immune;Immune checkpoint inhibitor;Immune system;Immunocompetent;Immunology;In Vitro;in vivo;in vivo Model;indexing;Infiltration;Inflammatory;Inflammatory Infiltrate;Malignant Epithelial Cell;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Microfluidics;Modeling;monocyte;mortality;mouse model;Mus;Neoplasm Metastasis;Nerve;nerve supply;Nervous System;neurogenesis;Neurons;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Patients;PD-1/PD-L1;Physicians;Prognosis;Proteins;recruit;Role;Scientist;Squamous Cell Lung Carcinoma;System;targeted treatment;Techniques;Testing;The Cancer Genome Atlas;therapeutic target;Tissues;Training;training project;transcriptome sequencing;tumor;tumor immunology;tumor microenvironment;tumor progression;Tumor-associated macrophages;United States;Up-Regulation;Work

PROJECT_TITLE: The Role of SPON1 Expressing Inflammatory Monocytes in Promoting Lung Cancer Metastasis.


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Complementary and Integrative Health;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Ocular pathologies and vision loss are understudied sequelae of numerous autoimmune diseases despite being prevalent in multiple sclerosis (MS), neuromyelitis optica (NMO), uveitis, and Sjogren’s syndrome. The proposed studies using a mouse model of MS are designed to advance a readily-implementable nutritional approach to mitigate autoimmune demyelinating optic neuritis.

PI_NAMEs: PLAFKER, SCOTT M (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: adaptive immunity;Adjuvant;Adoptive Transfer;Adverse effects;Anatomy;Anti-Inflammatory Agents;Autoimmune;Autoimmune Diseases;Autoimmunity;autoreactive T cell;Biological Assay;Blindness;Blood;Brain;Cardiovascular system;Cells;Central Nervous System Diseases;Clinical Trials;Consumption;cytokine;Demyelinations;design;Diagnostic;diagnostic biomarker;Diet;Diet Habits;dietary;Disease;dysbiosis;empowerment;Environment;Erythrocytes;Erythropoietin;experience;Experimental Autoimmune Encephalomyelitis;Eye;Fatty acid glycerol esters;Fatty Acids;Flare;Food;Fumarates;Goals;gut health;gut homeostasis;gut microbiome;Health;Homeostasis;IL17 gene;Immune;Immune Tolerance;Immunohistochemistry;Immunologics;immunoregulation;improved;in vivo;Incidence;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Intestinal permeability;Intestines;ITGAM gene;ketogenic diet;Leaky Gut;Life Style;Link;lipidomics;Measurement;Mediating;Medium chain triglycerides;Metabolic;Metabolic syndrome;migration;Modeling;monocyte;Motor;motor deficit;mouse model;Multiple Sclerosis;Multiple Sclerosis Lesions;multiple sclerosis patient;multiple sclerosis treatment;Mus;Natural Immunity;nerve damage;Neuromyelitis Optica;neuroprotection;novel;nutritional approach;Ocular Pathology;Optic Nerve;Optic Neuritis;Optics;Oral Administration;Outcome;Pain;Pathogenicity;Pathology;Patients;Plasma;Population;Predisposition;premature;preservation;prevent;Process;Proliferating;Psychophysics;Recombinant Erythropoietin;reconstitution;Reducing diet;remyelination;repaired;Reporter;Resolution;Retina;Site;Sjogren's Syndrome;Source;Spinal Cord;standard of care;systemic inflammatory response;T-Lymphocyte;Testing;Time;Treatment Efficacy;treatment response;Uveitis;Vision;Visual;Work

PROJECT_TITLE: Interrogating the intersection between diet and ocular autoimmunity

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: WASHINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Youth-onset type 2 diabetes is increasingly common and parallels the obesity epidemic, yet effective treatment and prevention strategies for high-risk children are extremely limited. It remains unclear why some high-risk youth experience normal pubertal progression, while others do not, despite similar physical and metabolic characteristics. The Biostatistics Research Center will provide the framework and infrastructure for the Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes Consortium though effective and collaborative organization, communication, and support, to successfully recruit a cohort of pubertal youth at risk for developing prediabetes and type 2 diabetes, deeply phenotype them through puberty, and contribute to a better understanding of the pathophysiology of youth-onset type 2 diabetes.

PI_NAMEs: BEBU, IONUT ;BRAFFETT, BARBARA HALINA (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Adolescent;Adult;adverse childhood events;Agreement;Beta Cell;Biometry;blood glucose regulation;Case Report Form;Cell Physiology;Certification;Characteristics;Child;Childhood;Chronic stress;Clinical Research;clinical research site;Clinical Trials;cohort;Collaborations;collaborative environment;Communication;comparative effectiveness study;Complications of Diabetes Mellitus;Conflict of Interest;Consent;Coupled;Creativeness;Data;data exchange;data management;Deterioration;Development;Devices;diabetes control;Diabetes Mellitus;diabetes prevention program;diabetes risk;effective therapy;Enrollment;Ensure;Environmental Risk Factor;Epidemiology;ethnic diversity;Ethnic Origin;Event;experience;follow-up;Functional disorder;Funding;Future;Gender;Genetic Materials;glycemic control;Goals;high risk;Hormonal;improved;Incidence;Infrastructure;innovation;Institutional Review Boards;Insulin Resistance;insulin secretion;insulin sensitivity;Intention;Intervention;Laboratories;Leadership;Logistics;Manuals;Manuscripts;Mediator;meetings;Metabolic;Methodology;Methods;Monitor;Multicenter Studies;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Obesity Epidemic;Observational Study;operation;Participant;Pathogenesis;Performance;Persons;Phenotype;Physiological;Physiology;Population Characteristics;Prediabetes syndrome;preservation;Prevalence;prevent;Prevention approach;Prevention strategy;primary outcome;Privatization;Procedures;Process;programs;progression risk;Protocols documentation;Puberty;Publications;Qualifying;quality assurance;Quality Control;Race;racial diversity;randomized trial;recruit;Reporting;repository;Research;Research Design;Research Personnel;Resources;response;Risk;Risk Factors;Safety;secondary outcome;sedentary lifestyle;Serious Adverse Event;Sex Differences;Site;Specific qualifier value;Statistical Data Interpretation;Statistical Methods;success;System;timeline;Training;Translating;treatment strategy;type 2 diabetes in children;Universities;user-friendly;Validation;virtual;Washington;web site;Youth

PROJECT_TITLE: Understanding and Targeting the Pathophysiology of Youth-onset Type 2 Diabetes - Biostatistics Research Center


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Natural Products;Women's Health Research

ORG_CITY: BAYAMON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSIDAD CENTRAL DEL CARIBE

ORG_STATE: PR

PHR: Public Health Relevance Triple negative breast cancer is a lethal cancer subtype that lacks targeted therapies and patients have a grim prognosis. Taking advantage of TNBC’s dependency on sterol uptake, removal of misfolded proteins and altered redox homeostasis, this application seeks to investigate ergosterol peroxide, a natural product sterol with promising cancer cell death inducing properties. Herein, we propose to demonstrate the mechanism of action by which EP suppresses cancer progression, as well as EPs safety and bioavailability to develop a promising therapeutic strategy for this intractable disease.

PI_NAMEs: MARTINEZ, MICHELLE M (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: 4T1;Address;Affect;African American;aggressive breast cancer;Aminoacyl-tRNA hydrolase;Ankyrin Repeat;anti-cancer therapeutic;antiproliferative agents;Apoptosis;Biological;Biological Assay;Biological Availability;Biomedical Research;Biophysics;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer subtypes;Cell Death;Cell Death Induction;Cell Line;Cell model;Cells;Cellular Assay;Cessation of life;Chemicals;chemotherapy;Cholesterol;Cholesterol Homeostasis;Clinic;Clinical Research;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Cytosol;Data;Death Rate;Dependence;Development;Diagnosis;Disease;Dose;Doxycycline;Drug toxicity;Early Diagnosis;efficacy evaluation;efficacy testing;Environment;Enzymes;ERBB2 gene;Ergosterol;Excision;Extravasation;Female;fungus;Future;Genes;Goals;Hispanic Americans;Homeostasis;Impairment;improved;In complete remission;in vivo;in vivo Model;inhibitor;Knowledge;Lead;Ligation;Malignant Breast Neoplasm;Malignant Neoplasms;MCF10A cells;Membrane;misfolded protein;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modality;Modeling;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Natural Products;neoplastic cell;Normal Cell;Normal tissue morphology;novel;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patient-derived xenograft models of breast cancer;Patients;Peroxides;pharmacokinetics and pharmacodynamics;pharmacologic;pre-clinical;Prognosis;Property;Protac;protein aggregation;protein complex;Proteins;public health relevance;Puerto Rico;Recurrent disease;Research;Resistance;Safety;Scientist;stem;Sterols;Structure;student participation;Students;Substrate Specificity;Survival Rate;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Toxic effect;triple-negative invasive breast carcinoma;tumor progression;Tumor Volume;Ubiquitin;Ubiquitination;underrepresented minority student;United States;uptake;valosin-containing protein;Woman;women of color;Xenograft procedure;Zinc Fingers

PROJECT_TITLE: Validating the mode of action of ergosterol peroxide as a selective breast cancer inhibitor


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative The neural circuit that controls mammalian reproduction feeds information on circadian rhythms from the suprachiasmatic nucleus via the neuropeptides arginine vasopressin and vasoactive intestinal peptide to the kisspeptin and gonadotropin-releasing hormone neurons, respectively, and the kisspeptin neurons detect sex steroid hormone status to integrate these signals to the gonadotropin-releasing hormone neurons. All of these hypothalamic neuronal populations depend on homeodomain proteins for development and function, in particular, Ventral Anterior Homeobox 1 (Vax1), Six3, and Six6. Defects in this hypothalamic neuronal circuit cause infertility and subfertility and alter circadian rhythms; thus, elucidation of the molecular and cellular mechanisms underlying development, migration, network formation, and responses to circadian cues of this hypothalamic circuit, are critical for our understanding of hypothalamic development and reproductive function.

PI_NAMEs: MELLON, PAMELA L (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Adult;Anterior;Apoptosis;Argipressin;Axon;Cell Differentiation process;Cell Line;Cells;circadian;circadian pacemaker;Circadian Rhythms;Cues;Defect;Development;Embryo;Estrous Cycle;Exhibits;experience;Failure;Feeds;Fertility;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Heterozygote;Homeobox;homeodomain;Homeodomain Proteins;Hormones;Hypothalamic structure;In Vitro;in vitro Model;in vivo;Infertility;innovation;insight;KISS1 gene;Knock-out;Knockout Mice;Laboratories;male;median eminence;Methodology;migration;Molecular;Morphology;Mus;Mutation;neural circuit;Neurites;Neuroendocrine Cell;neuron development;neuronal circuitry;Neurons;Neuropeptides;Neurosecretory Systems;novel;Olfactory Nerve;Pathway interactions;Perinatal mortality demographics;Physiological;Pituitary Gland;Population;promoter;Puberty;Regulation;Regulatory Pathway;Reproduction;reproductive;reproductive function;response;Role;Sex Behavior;Signal Transduction;Small Interfering RNA;subfertility;suprachiasmatic nucleus;Testosterone;transcription factor;Transfection;Transgenic Organisms;Vasoactive Intestinal Peptide;Ventral Anterior Thalamic Nucleus;VIP gene

PROJECT_TITLE: Neurosecretory Gene Expression in the Hypothalamus


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Mental illness characterized by dysregulated behaviors contribute to emotional and physical suffering and are associated with high healthcare costs and increased risk of death to the self and others. The proposed training program will train the next generation of investigators pursuing translational research to reveal the underlying mechanisms contributing to mental illness and reduce disorder-related suffering, economic burden, and mortality through identifying novel targets for prevention and treatment.

PI_NAMEs: ECKEL, LISA A;KEEL, PAMELA K. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Integrated Clinical Neuroscience Training for Translational Research


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative Cell fate recommitment underlies the pathogenesis of multiple esophageal diseases including Barrett’s esophagus and small cell carcinoma in the esophagus. This proposal will identify the mechanism by which the transcription factor p63 safeguards esophageal basal progenitor cells from neuroendocrine cell differentiation. The knowledge gained will be used for comprehensively identifying new therapeutic targets for treating esophageal diseases involving cell fate switch.

PI_NAMEs: LU, CHAO ;QUE, JIANWEN  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Adult;ASCL1 gene;ATAC-seq;Automobile Driving;Barrett Esophagus;Binding;Binding Sites;Biochemistry;Biological Assay;Biology;Candidate Disease Gene;Cell Differentiation process;Cell Fate Control;Cell Line;Cells;Cellular biology;ChIP-seq;Chromatin;Complex;Data;Data Set;derepression;Disease;effective therapy;Embryo;Epigenetic Process;epigenetic regulation;epigenetic silencing;epigenomics;Epithelium;Esophageal carcinoma;Esophageal Diseases;Esophagus;EZH2 gene;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;genome-wide;Germ Cells;Germ Lines;Goals;High-Throughput Nucleotide Sequencing;Human;human pluripotent stem cell;inhibitor;insight;insulinoma associated 1;Joints;Knockout Mice;Knowledge;Lesion;Mediating;member;Modeling;Molecular;mouse genetics;mouse model;Mus;Neuroendocrine Cell;neuroendocrine differentiation;Neuroendocrine Tumors;Neurosecretory Systems;new therapeutic target;novel;novel strategies;Pathogenesis;Play;pluripotent stem cell differentiation;Polycomb;postnatal;programs;Promoter Regions;Protein Isoforms;Role;Small Cell Carcinoma;Specific qualifier value;Squamous Cell;Squamous Differentiation;stem cell differentiation;stem cells;Stratified Squamous Epithelium;Surveys;Testing;transcription factor;transcriptome sequencing;Transposase;Work

PROJECT_TITLE: Cell Fate Regulation in Esophageal Progenitor Cells

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: FLUSHING

ORG_NAME: QUEENS COLLEGE

PHR: Public Health Narrative Proper microglia functioning is necessary for a healthy brain; disruption of microglia can alter behavior and lead to neurological pathologies. We will study how microglia are regulated by sensory experience and in turn how they may impact the perineuronal net, a neuron specific form of the extracellular matrix. The perineuronal net protects cells from oxidate stress and constrains neural alterations in adulthood. How microglia and the perineuronal net interact is unknown and will be the focus of the present study using a synthesis of anatomical, physiological and behavioral experiments.

PI_NAMEs: BRUMBERG, JOSHUA CRAIG (contact)

PROJECT_TITLE: Microglial interactions with the Perineuronal Net


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE A better understanding of factors contributing to sustainability of evidence-based interventions is urgently needed to improve childhood cancer survival in low-resource settings. This project studies the ability of low- resource hospitals in Latin American to sustain an evidence-based intervention, a Pediatric Early Warning System (PEWS), that improves outcomes among hospitalized children with cancer. Upon completion, this study will identify components of clinical capacity that contribute to long-term sustainability of interventions in low-resource hospitals and develop strategies to promote sustainability, thus advancing the science of implementation and improving survival for children with cancer globally.

PI_NAMEs: AGULNIK, ASYA  (contact);MCKAY, VIRGINIA R

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Address;Administrator;Admission activity;Adopted;Adoption;cancer care;cancer survival;cancer therapy;Cessation of life;Childhood;Clinical;cohort;Country;design;Deterioration;Early identification;Equity;Evaluation;evidence base;Evidence based intervention;Face;Failure;Focus Groups;Goals;Health;health equity;Hospitalized Child;Hospitals;implementation intervention;implementation process;implementation science;improved;improved outcome;Individual;innovation;Intervention;Investments;Knowledge;Latin American;Leadership;longitudinal, prospective study;Malignant Childhood Neoplasm;Maps;Measurement;Mentors;Methods;Modernization;Monitor;mortality;novel;novel strategies;Nurses;organizational readiness;Outcome;Patient-Focused Outcomes;Patients;Pediatric Oncology;Phase;Predictive Factor;prevent;preventable death;prospective;Registries;Resource-limited setting;Resources;Saint Jude Children's Research Hospital;Standardization;Supportive care;Surveys;System;Testing;Time;Toxic effect;Training;Universities;Washington;wasting;Work

PROJECT_TITLE: Sustainability determinants of an intervention to identify clinical deterioration and improve childhood cancer survival in low-resource hospitals

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Services;Human Genome;Pediatric;Rare Diseases

ORG_CITY: IRVINE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PUBLIC HEALTH NARRATIVE Mendelian conditions, particularly those presenting during childhood, are a major disease burden causing suffering and taxing the healthcare system, yet are difficult to diagnose. To improve the rate of diagnosis, we propose a Pediatric Mendelian Genomics Research Center, leveraging the pediatric clinical and research expertise of Children’s National Hospital and Research Institute in a partnership with Invitae, a world leader in affordable and comprehensive genetic testing, and incorporating innovative sequencing and variant evaluation strategies to better discover disease-causing variants. Our center, in collaboration with the other Mendelian Genomic Research Centers, will draw from a large and diverse population to identify the underlying causes of Mendelian disease and translate the findings into clinical practice.

PI_NAMEs: VILAIN, ERIC J. (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Acceleration;Affect;Alleles;Basic Science;Benign;burden of illness;Candidate Disease Gene;Categories;Child;Childhood;Classification;Clinical;clinical implementation;clinical practice;Clinical Research;ClinVar;Code;cohort;Collaborations;Communication;community center;Consanguinity;Copy Number Polymorphism;Data;Data Coordinating Center;data dissemination;data sharing;Diagnosis;diagnostic strategy;Disease;Disease Management;disease phenotype;disease-causing mutation;Ensure;Evaluation;exome sequencing;Family;Family member;gene discovery;Genes;Genetic;Genetic Counseling;genetic testing;genetic variant;genome-wide;genomic data;Genomics;Goals;Health Personnel;Healthcare Systems;Hospitals;improved;Individual;industry partner;innovation;Interdisciplinary Study;Investigation;Maps;Mendelian disorder;Methods;Modeling;Molecular;mRNA Expression;novel;Optics;participant enrollment;Pathogenicity;patient registry;Patients;Phenotype;Population;Population Heterogeneity;Process;Proxy;public database;Public Health;Publications;Publishing;Rare Diseases;rare mendelian disorder;recruit;repository;Reproducibility;Research;Research Institute;RNA Splicing;Sampling;Source;Standardization;Structure;symposium;System;Taxes;Technology;Testing;Tissues;transcriptome;transcriptome sequencing;Translating;Translational Research;Untranslated RNA;Variant;variant of unknown significance;whole genome


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Precision Medicine

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative When cancer cells sustain deletion of a tumor suppressor gene, neighboring genes are invariably co-deleted. When the passenger deleted gene is a member of a gene family that encodes a cell essential function, the redundant gene (co-expressed paralog) residing elsewhere in the genome represents a cancer-specific vulnerability that would spare normal cells with intact genomes. We believe that this proposed research study will identify multiple novel drug targets for cancer treatment, thereby improving outcomes and prolonging patients’ lives.

PI_NAMEs: DEPINHO, RONALD ANTHONY (contact);HART, GLEN TRAVER

PROGRAM_OFFICER_NAME: HUGHES, SHANNON K

PROJECT_TERMS: 1p36;Adult;Alleles;Apoptotic;ARID1A gene;Biochemical;Biological;Biological Assay;cancer cell;Cancer cell line;cancer therapy;cancer type;candidate validation;CDKN2A gene;Cell Culture Techniques;Cell division;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Chromosomes;Cleavage Stimulation Factor;Clustered Regularly Interspaced Short Palindromic Repeats;Common Neoplasm;Complex;Computer Analysis;Computing Methodologies;Coupled;CRISPR/Cas technology;Cultured Cells;Data;deep learning;Defect;Dependence;design;Diphosphates;drug discovery;Endoplasmic Reticulum;Engineering;enzyme activity;Enzymes;Event;Extinction;Face;gain of function;Gene Deletion;Gene Family;Genes;Genetic;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;Housekeeping;Human;improved outcome;in vivo;Individual;Knock-out;Lactate Dehydrogenase;Ligase;live cell imaging;MADH4 gene;malic enzyme;Malignant Neoplasms;Mammalian Cell;Maps;Measurement;Measures;Mediating;member;Metabolism;metabolomics;Methods;Mitochondria;Mitosis;Mitotic spindle;model organism;Modeling;Monitor;mRNA Precursor;Mus;mutant;new therapeutic target;NF1 gene;NF1 tumor suppressor;Normal Cell;Nuclear Envelope;nucleotide metabolism;Organoids;Orthologous Gene;overexpression;paralogous gene;Patients;pharmacologic;Phosphatidylserine Synthase;Phosphatidylserines;Polyadenylation;Precision cancer therapy;Probability;Proteins;Proteomics;PTEN gene;public database;Pyruvate;RB1 gene;receptor expression;Reiterated Genes;research study;response;Ribose-Phosphate Pyrophosphokinase;Sample Size;screening;Sequence Deletion;Signal Transduction;small hairpin RNA;Survival Analysis;System;Systemic Therapy;targeted treatment;tool;Toxic effect;TP53 gene;transcriptomics;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;U1 small nuclear RNA;Validation;validation studies;vector;whole genome

PROJECT_TITLE: Identifying and targeting collateral lethal vulnerabilities in cancers


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The NICHD MFMU Network conducts randomized clinical trials and large-scale observational studies designed to improve maternal and perinatal outcomes. For the past 27 years, the Utah Network Center has been a major contributor of research protocols and high-quality research data derived from a large, community-based population in the Intermountain West. The Utah Center’s impressive past performance and it’s stable long-term capabilities make it an ideal candidate to continue its work on MFMU Network protocols through 2030.

PI_NAMEs: METZ, TORRI D (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accounting;Address;African;antenatal;Arizona;Caring;Catchment Area;Clinic;Clinical;clinical center;Clinical Research;clinical translation;Collaborations;Colorado;Communities;Community Participation;Complement;Conduct Clinical Trials;Data;data quality;Dedications;Department chair;Development;Discipline of obstetrics;Drug Kinetics;Enrollment;Ensure;experience;fetal;follow-up;Follow-Up Studies;frontier;Funding;Geography;Health Sciences;Healthcare;High-Risk Pregnancy;Hospital Administrators;Hospitals;Human;Idaho;improved;Infant;Investigational Drugs;Lactation;Letters;Location;Longterm Follow-up;maternal morbidity;Maternal Mortality;maternal risk;Maternal-Fetal Medicine Units Network;Medical;member;Montana;Mothers;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Native American community;Native Hawaiian;Native Hawaiian or Other Pacific Islander;Neonatal;Neonatal Intensive Care Units;neonate;Nevada;New Mexico;Observational Study;Obstetric pharmacology;Pacific Islander;Participant;Patients;Pediatric Hospitals;Performance;Perinatal;perinatal outcomes;Persons;Pharmacy facility;Physician Executives;Policies;Population;population based;Population Heterogeneity;Post-Acute Sequelae of SARS-CoV-2 Infection;pregnant;Process;Productivity;programs;Protocols documentation;Provider;Publications;randomized, clinical trials;recruit;Refugees;Research;Research Design;Research Personnel;research study;retention rate;Rural;Science;screening;secondary analysis;Services;Silver;Site;Specimen Handling;success;Testing;Translational Research;Ultrasonography;United States National Institutes of Health;Universities;Utah;Work;Wyoming

PROJECT_TITLE: UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical Centers


NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness in African Americans. This proposal will identify and investigate genetic variants of biologic importance to this disease using genotypic and phenotypic data from the Primary Open- Angle African American Glaucoma Genetics study cohort. Our findings will contribute to the development of more targeted screening and precise therapeutic interventions for this blinding disease.

PI_NAMEs: O'BRIEN, JOAN M (contact)

PROJECT_TERMS: Address;Affect;African American;African American population;African ancestry;Age;American;Authorization documentation;Bilateral;Biological;Biological Models;blind;Blindness;burden of illness;causal variant;Cell Culture Techniques;Cell model;Cells;Cities;Clinical;Code;cohort;Cohort Studies;CRISPR/Cas technology;Data;Development;Disease;Disparity;DNA sequencing;economic outcome;Electrophysiology (science);endophenotype;Enhancers;Ethnic Population;European;exome;exome sequencing;experience;Familial disease;Funding;gene function;Generations;Genes;Genetic;genetic information;Genetic Predisposition to Disease;Genetic study;genetic variant;Genetic Variation;genome editing;genome wide association study;genome-wide;genome-wide analysis;genomic data;Genomics;Genotype;Glaucoma;Goals;Health;human data;Individual;induced pluripotent stem cell;interest;Intervention;Lentivirus Vector;loss of function;Meta-Analysis;Modeling;Morphology;novel;optic nerve disorder;overexpression;Pathway interactions;Patients;Persons;Phase;Phenotype;phenotypic data;Philadelphia;polygenic risk score;Population;Precision therapeutics;Predisposition;pressure;Prevalence;Primary Open Angle Glaucoma;promoter;Public Health;rare variant;Recontacts;recruit;Retinal Ganglion Cells;Risk;Role;screening;SNP array;Specialist;structural genomics;Structure;success;Susceptibility Gene;Symptoms;Target Populations;Testing;Therapeutic Intervention;Trabecular meshwork structure;trait;transcriptome;transcriptome sequencing;Untranslated RNA;Variant;Visual impairment

PROJECT_TITLE: Primary Open Angle African-American Glaucoma Genetics Study Renewal


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative/Relevance to public health statement The NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course) is a 4.5-day multidisciplinary in-person clinical trial training course providing focused instruction on the design, conduct and analysis of ADRD clinical trials, ranging from mechanistic studies to large, community-based interventions. Multidisciplinary training that combines traditional clinical trials education with specialized skills in biostatistics, study recruitment, study organization, neuropsychology, ethics and informatics will accelerate the establishment of a new, diverse and well-trained cadre of investigators to lead the development of therapies for ADRD, a key priority for improving public health.

PI_NAMEs: GRILL, JOSHUA ;RAMAN, REMA  (contact)

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Acceleration;Achievement;Active Learning;Address;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;Area;Award;Biological Markers;Biometry;Budgets;career;Caring;Characteristics;Clinical;clinical care;Clinical Investigator;Clinical Trials;cohort;Communication;Communities;community intervention;Continuing Education;design;Development;Diagnosis;Disabled Persons;disadvantaged background;Disparity population;Diverse Workforce;Education;education resources;Elements;Ensure;Ethics;Ethnic Population;Evaluation;Evidence Based Medicine;Evolution;experience;Faculty;Fellowship;follow-up;Funding;Generations;Geriatrics;Goals;Grant;Hispanic-serving Institution;Historically Black Colleges and Universities;improved;Individual;Informatics;Infrastructure;innovation;Instruction;Interdisciplinary Study;Knowledge;Lead;Learning;Long-Term Effects;Measures;Medical;Medical Research;medical specialist;medical specialties;meetings;Mentors;Mentorship;Methodology;Methods;Minority Groups;Mission;Modernization;Monitor;multidisciplinary;multimodal learning;multimodality;National Institute on Aging;Neuropsychology;neuropsychopharmacology;next generation;novel;Outcome Study;outreach;Participant;Patient Recruitments;Persons;Principal Investigator;Professional Organizations;programs;Protocols documentation;Public Health;racial population;recruit;Request for Proposals;Research;Research Personnel;Resources;satisfaction;Science;Scientist;skills;sociodemographics;Sorting;Source;Structure;success;symposium;therapy development;Training;Training Programs;trial design;United States National Institutes of Health;virtual education;Woman;workforce needs


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Depression;Estrogen;Mental Health;Neurosciences;Pediatric;Prevention;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Millions of individuals take hormonal contraceptives (HC) often starting at adolescence when ovarian hormones have important effects on maturation of the prefrontal cortex (PFC). Yet, there is a fundamental lack of information about the consequences of hormonal alterations with adolescent HC use on PFC development. Considering that HC usage among adolescents has been associated with greater depression risk in adulthood, understanding how HC influence mood regulating brain regions like the PFC is critical and will better inform the use of HC among teens.

PI_NAMEs: LENZ, KATHRYN M.;LEUNER, BENEDETTA J (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Acne;Address;Adolescence;Adolescent;adolescent brain development;Adrenal Cortex Hormones;Adult;aged;analog;anti-depressive agents;Behavior;Behavioral;behavioral health;behavioral outcome;Blood;Brain;brain health;Brain region;Cells;clinical effect;Cognitive;Contraceptive Agents;Contraceptive Usage;Corticosterone;critical developmental period;critical period;Data;Development;DLG4 gene;Dysmenorrhea;Elements;Endocrine;Estradiol;Ethinyl Estradiol/Levonorgestrel;experimental study;Exposure to;Feedback;Female;Female Adolescents;flexibility;Glucocorticoids;Goals;Gonadal Steroid Hormones;Hormonal;hormonal contraception;Hormones;Human;Hydrocortisone;hypothalamic pituitary gonadal axis;hypothalamic-pituitary-adrenal axis;Immune;Impairment;Individual;innovation;interest;Knowledge;Lead;life span;Link;Major Depressive Disorder;Medial;Mediating;Mental Depression;Microglia;Modification;Moods;neurodevelopment;Neurons;Neurosecretory Systems;neurosteroids;Ovarian hormone;Peripheral;Persons;Phagocytosis;Pharmacologic Substance;Play;Prefrontal Cortex;Process;Progesterone;Puberty;Rattus;receptor expression;Regulation;Reporting;Research;response;Risk;Rodent;Role;sex;sexually active;Shapes;steroid hormone;steroid hormone receptor;Stress and Coping;Structure;suicidal risk;Synapses;synaptic pruning;Teenagers;Testing;Time;United States;Woman;Women's Health;women's treatment

PROJECT_TITLE: Hormonal Contraceptives and Adolescent Brain Development

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Genomic integrity is challenged by spontaneous DNA damage that results from endogenous and exogenous sources. This proposal focuses on elucidating the molecular mechanisms by which cells detect and repair the most common forms of DNA damage, especially single strand breaks and damaged bases. This information is critical to understanding the impact of genetic deficiencies, exposure to carcinogens, and to improving cancer therapy.

PI_NAMEs: O'BRIEN, PATRICK J (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Age;base;Base Excision Repairs;Biochemical;Biological;Biophysics;cancer therapy;Carcinogens;Cell Death;Cells;Clinical;Disease;DNA Damage;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;Enzymes;Exposure to;Failure;Genetic;genome integrity;Genotoxic Stress;Genotype;Goals;Human;improved;interdisciplinary approach;Kinetics;Malignant Neoplasms;Modeling;Molecular;Mutagenesis;Mutation;Phenotype;repaired;Risk;Site;Somatic Mutation;Source;Structure;System;Time;Training;Translating;Work

PROJECT_TITLE: Mechanisms of Base Excision DNA Repair

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE The events of developmental programming are thought to contribute to an increased prevalence of metabolic disorders, but the physiological events driving the programming of key neural inputs linked to the homeostatic processes of drinking and feeding remain poorly understood. This proposal will be the first step in defining the developmental integration of drinking and feeding states during the neonatal period in the hypothalamus. The results of this proposal will provide new insight into unappreciated developmental events that impact metabolic phenotypes throughout life, which could ultimately lead to new therapeutic targets for metabolic disorders.

PI_NAMEs: SWEET, SERENA  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Acute;Adult;Affect;Age;Anatomy;Anorexia;Appetite Stimulants;Architecture;Automobile Driving;Behavior;Behavior assessment;Behavioral;Blood;Body Weight;Body Weight decreased;Body Weights and Measures;Brain;Communication;Confocal Microscopy;Consumption;critical developmental period;critical period;Cues;Dehydration;Dependence;Development;drinking;energy balance;Environmental Risk Factor;Event;experimental study;Exposure to;feeding;Fluid Balance;Food;Genetic Recombination;Health;Homeostasis;Hunger;Hypothalamic structure;Immunohistochemistry;Impairment;Ingestion;insight;Intake;Label;Leptin;Life;Link;Liquid substance;Malnutrition;Maps;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Milk;milk intake;Mus;Neonatal;neonatal mice;neonatal period;nerve supply;neural;neural circuit;Neural Pathways;Neuroanatomy;Neurons;Neuropeptides;Neurosecretory Systems;neurotransmission;new therapeutic target;Nipples;Nitric Oxide Synthase Type I;novel;Nutrient;Nutritional;Obesity;offspring;Organism;Osmolalities;Overnutrition;paraventricular nucleus;Peptides;Physiological;Physiology;Population;Positioning Attribute;postnatal;preoptic nucleus;Prevalence;Process;pup;Rattus;Regulation;response;Saline;Signal Transduction;Solid;Specific qualifier value;Structure of nucleus infundibularis hypothalami;Testing;Thirst;Time

PROJECT_TITLE: Developmental programming of neural circuits integrating drinking and feeding


NIH_SPENDING_CATS: Cystic Fibrosis;Lung;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE These studies will use a novel mucociliary transport assay that can measure mucus transport in the small airways at a spatial and temporal resolution not achieved before. By studying defects in CF pigs, we develop understanding of the mechanism of mucociliary transport and how it is controlled.

PI_NAMEs: ABOU ALAIWA, MAHMOUD  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Affect;Air;Airway Disease;airway epithelium;Algorithmic Analysis;Alveolar;Animal Model;Anions;Asthma;Back;Biological Assay;Biological Models;Birth;Blood;Characteristics;children with cystic fibrosis;Chronic Obstructive Pulmonary Disease;Cilia;Clinical;Cystic Fibrosis;cystic fibrosis airway;Cystic Fibrosis Transmembrane Conductance Regulator;Data;Defect;Development;digital;disease model;Distal;Duct (organ) structure;Early Intervention;Elasticity;Environment;Event;Family suidae;Functional disorder;Gases;Genetic Transcription;Gland;Goals;Host Defense Mechanism;idiopathic pulmonary fibrosis;Impairment;in vivo;Individual;Inhalation;innovation;Invaded;Liquid substance;Locomotion;Lung;Lung Diseases;Measures;Mediating;Microbe;model organism;Motion;Movement;Mucociliary Clearance;Mucolytics;Mucous body substance;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Organism;Outcome;Outcome Study;Oxygen;particle;Particle Size;pathogen;Pathogenesis;Periodicals;PET/CT scan;Positron;Positron-Emission Tomography;preference;prevent;Primary Ciliary Dyskinesias;Process;Property;radiotracer;Research;Role;Signal Transduction;Slice;Submucosa;success;Surface;System;Techniques;temporal measurement;Testing;Therapeutic;Time;Trachea;Transgenic Animals;tris(2-carboxyethyl)phosphine;Tube;viscoelasticity

PROJECT_TITLE: Contribution of Small Airways to Mucociliary Transport Dysfunction

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: BROOKLYN COLLEGE

PHR: Project Narrative: Numerous reports link socioeconomic and ethnic disparities to the frequency, lack of care, and severity of chronic disorders and disabilities in US minority and low-income populations compared with majority, more affluent groups. Training a diverse research workforce to address these disparities is increasingly critical when considering the burden on society of unequal health care. The aim of Brooklyn College’s U-RISE proposal is to increase the impact of research produced by individuals from diverse backgrounds to avoid even greater health disparities in the future.

PI_NAMEs: HAINLINE, LOUISE ;TORRENTE, MARIANA PLAZAS (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Achievement;Bachelor's Degree;Biomedical Computing;CCL7 gene;college;Communication;Development;Doctor's Degree;Eligibility Determination;Ethnic Origin;experience;Faculty;faculty mentor;Family;improved;Individual;Institution;Instruction;Low income;matriculation;member;Mental Health;Mentors;Mentorship;New York City;pandemic impact;Personal Satisfaction;Preparation;programs;Race;recruit;Reproducibility;Research;Research Design;responsible research conduct;Science;science education;Self Efficacy;skills;Social support;statistics;STEM career;Student recruitment;Students;Study Skills;synergism;Teacher Professional Development;Training;undergraduate research;undergraduate research experience;Underrepresented Populations;university student

PROJECT_TITLE: U-RISE at Brooklyn College

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE: Melanocyte regeneration is important for the homeostasis and repair of pigmented skin. This proposal seeks to identify and characterize genetic and cellular factors that guide melanocyte regeneration, both by identifying and characterizing human melanocyte stem cells and utilizing the advantages of functional analyses available in the zebrafish system. The knowledge gained from these studies aims to positively impact treatment of individuals with pigmentary disorders, including the 0.2-1.8% of the world’s population with vitiligo.

PI_NAMEs: CEOL, CRAIG JOSEPH (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Ablation;Adopted;Affect;Autoimmune Diseases;Autologous Transplantation;Biological Assay;Biological Models;BRAF gene;Bulla;Cell Lineage;Cell Maintenance;cell type;Cells;combinatorial;Data;Disease;Dissection;Drug resistance;experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;Homeostasis;Human;Hypopigmentation;Immersion;Immune checkpoint inhibitor;Individual;inhibitor therapy;insight;Knowledge;Lead;Lesion;Macrophage;Maintenance;Maps;Measures;Mediating;melanocyte;Melanoma;Melanoma Cell;Methodology;Molecular;Natural regeneration;NGFR gene;novel;Pathway interactions;patient subsets;Patients;Pharmacotherapy;Phototherapy;Population;Procedures;Process;psychologic;Recovery;regenerative cell;repaired;Resistance;Resources;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;Skin Pigmentation;social;stem cell biology;stem cell fate;stem cell genes;stem cell self renewal;stem cells;Stigmatization;System;Techniques;Time;tissue injury;tissue regeneration;Tissues;transcriptomics;tumor;Ultraviolet Rays;Vitiligo;Zebrafish

PROJECT_TITLE: Cellular and molecular regulators of melanocyte regeneration

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Spontaneous brain activity drives dramatic variability in both neural and perceptual responses to identical sensory stimuli. Although this finding has sparked myriad resting state fMRI studies searching for links between spontaneous brain states and psychiatric diagnoses, little is understood about the fundamental neurocognitive processes underlying spontaneous brain states. My proposal applies cutting-edge technologies to reveal the predictive functions and basic circuit mechanisms underlying spontaneous cortical states, with the ultimate goal of generating novel insights into how resting state activity contributes to psychiatric illness.

PI_NAMEs: MITRA, ANISH  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Advisory Committees;Animal Behavior;Area;Arousal;Automobile Driving;Behavior;behavior prediction;Behavioral;behavioral response;Belief;Bilateral;Brain;Calcium;career;Cells;cognitive control;cognitive neuroscience;cognitive process;Complex;Data;Decision Making;Detection;Development;Dorsal;Environment;Expert Systems;Fellowship;Female;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Halorhodopsins;Head;hippocampal pyramidal neuron;Human;Image;Injections;insight;Interneurons;Investigation;Knowledge;Link;male;Mathematics;Mental Depression;Mental disorders;Mentors;Mentorship;Methods;Modeling;mouse model;multidisciplinary;Mus;National Institute of Mental Health;Nervous System;neural;Neurocognitive;neurocognitive disorder;neuroimaging;neuromechanism;Neurons;neuroregulation;Noise;novel;optical imaging;optogenetics;Pattern;Perception;Physicians;Positioning Attribute;Post-Traumatic Stress Disorders;predicting response;Process;Psychiatric Diagnosis;Psychiatry;Psychophysics;Publications;Recording of previous events;Reporting;Reproducibility;Research;Research Personnel;response;Rest;Rewards;Rodent;Role;Schizophrenia;Scientist;sensory stimulus;Shapes;Signal Transduction;Somatostatin;Specificity;Stimulus;Structure;System;Technology;Testing;theories;Training;Variant;Visual;Visual Cortex;visual processing;Visual System;Water;Work

PROJECT_TITLE: Predictive Functions and Neural Mechanisms of Spontaneous Cortical Activity

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: SEATTLE

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative MEG has an excellent spatiotemporal resolution and it is an excellent tool for non-invasive study of normal brain functions as well as diagnosis of a large variety of neurological conditions including epilepsy, autism spectrum disorders, Parkinson’s disease, and Alzheimer’s disease. The spatial resolution of MEG is limited by the signal-to-noise ratio of brain-related magnetic fields but also the fact that the spatially smooth features of the brain signals dominate the measurements over the more fine-detailed components. This research will provide novel mathematical methods to extract and emphasize the fine-detailed field components, both in terms of mathematical modeling and design of novel MEG sensor array geometries.

PI_NAMEs: TAULU, SAMU  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Anatomy;Area;autism spectrum disorder;Brain;Brain imaging;Brain region;Clinical;Clinical Research;Compensation;Complex;Data;Derivation procedure;design;Detection;Development;Devices;Diagnosis;Diagnostic;electric field;Electroencephalography;Epilepsy;Etiology;experimental study;flexibility;Frequencies;Functional Imaging;Geometry;Head;Helmet;Human;human data;human subject;imaging modality;improved;Individual;individual patient;interest;Lead;Location;magnetic field;Magnetism;Magnetoencephalography;mathematical methods;mathematical model;Measurement;Measures;Methodology;Methods;Modality;Modeling;Movement;Nervous System Disorder;neural;Neurologic;Neurology;Neurosciences;Noise;non-invasive imaging;novel;operation;Optics;Parkinson Disease;Positioning Attribute;Pump;reconstruction;Research;Resolution;Scalp structure;sensor;sensor technology;Shapes;signal processing;Signal Transduction;simulation;Source;spatiotemporal;Structure;superconducting quantum interference device;System;Techniques;Testing;Time;tool;Translating;treatment planning;Validation;vector;wearable device

PROJECT_TITLE: Spatial-frequency decompositions for enhancement of source reconstruction resolution in MEG

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Cadmium is a toxic metal that is a major public health concern, due to its ubiquity in the human environment. If successful, our work will show that exposure to cadmium during development causes non-alcoholic fatty liver disease in later life through activating a specific set of genes, identifying these genes as potential markers of disease susceptibility and novel targets for treatment. Given that NAFLD affects 30-40 % of the US adult population, and has been linked to metabolic impairments and a shorter lifespan, findings from our work have the potential to improve disease prediction and management for a large number of people.

PI_NAMEs: COWLEY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Adult;Affect;Alleles;Behavior Disorders;Cadmium;Cardiovascular Diseases;Cell Culture Techniques;Cell model;Chemicals;Child;Data;Deposition;Development;developmental disease;Disease;Disease Marker;Disease susceptibility;disorder prevention;DNA;DNA Methylation;Dose;Environment;Epigenetic Process;Event;Exposure to;Extracellular Matrix;Fatty acid glycerol esters;Functional disorder;Gene Activation;gene network;Genes;Genetic;Genetic Transcription;genome-wide;Health;Heavy Metals;Hepatic Stellate Cell;Hepatocyte;high risk;Human;human data;human model;Impairment;imprint;improved;in vivo;Inflammation;K-Series Research Career Programs;Kidney;Knowledge;late life;Lead;Life;life span;Link;Lipids;Liver;liver metabolism;Malignant neoplasm of liver;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;Molecular;Molecular Profiling;Molecular Target;mouse model;Mus;National Institute of Environmental Health Sciences;Nature;new therapeutic target;Newborn Infant;non-alcoholic fatty liver disease;North Carolina;novel;Onset of illness;overexpression;Paracrine Communication;Pathway interactions;Patients;Persons;Play;Population;Pregnant Women;prevent;Production;Program Development;programs;Public Health;Relaxation;Respiratory System;Role;Skeletal system;stressor;System;Testing;Therapeutic Intervention;Tissues;Toxic effect;toxic metal;toxicant;Umbilical Cord Blood;Up-Regulation;Work;World Health Organization

PROJECT_TITLE: The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions

ORG_CITY: NEW HAVEN

ORG_DEPT: CHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative Enzymes turn atmospheric nitrogen into ammonia, and turn carbon dioxide into reduced products; in both cases, they use clusters of iron and sulfur atoms. The mechanisms of these clusters are unclear, and we propose to prepare new chemical compounds with iron-sulfur environments that resemble those in the clusters. Using these synthetic clusters, we will illuminate the fundamental chemistry underlying their reactions in nature.

PI_NAMEs: HOLLAND, PATRICK L (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Active Sites;Amaze;Ammonia;analog;Atmosphere;Behavior;Binding;Binding Sites;biological systems;Biomimetics;Carbon Dioxide;Carbon monoxide dehydrogenase;Catalytic Domain;Charge;Chemicals;Chemistry;cofactor;Complex;Confusion;Coupled;Coupling;Crystallography;design;diazene;Educational process of instructing;Electron Transport;Electrons;Environment;enzyme mechanism;enzyme substrate;Enzymes;Equilibrium;experience;feasibility testing;Future;Geometry;Hydrogen Bonding;innovation;Inorganic Chemistry;insight;Iron;Iron Compounds;Knowledge;Ligands;Mediating;metallicity;metalloenzyme;Metalloproteins;Metals;migration;Modeling;molecular orbital;Movement;Nature;Nickel;Nitrogen;Nitrogenase;novel;Organometallic Chemistry;oxidation;Oxidation-Reduction;Pathway interactions;Pattern;Process;Proteins;Protons;Reaction;Reducing Agents;sample fixation;Science;Shapes;Site;small molecule;spectroscopic survey;Spectrum Analysis;Structure;success;Sulfides;Sulfur;System;Testing;Time;Work

PROJECT_TITLE: Low-Coordinate Synthetic Models for Iron-Sulfur Enzymes

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Data Science;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: This project will focus on large-scale retinal imaging genetics data mining, develop and validate an automated early ocular disease prediction and decision support system to identify risk factors and detect patients at risk of ocular disease. The ultimate goal is to have the model monitor patients and identify those at high risk during very early stage, thus the ophthalmologists can act on these patients before the irreversible outcome occurs to provide the precision healthcare.

PI_NAMEs: CHEN, WEI ;HUANG, HENG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acceleration;Address;Adult;Age;Big Data;Blindness;case control;Child;Chronic;Clinical Data;Clinical Management;cohort;Complex;Data;data complexity;data integration;data mining;Data Science;Data Set;Decision Support Systems;deep learning model;design;Development;Dimensions;disability;Disabling condition;Disease;disease diagnosis;Disease Management;disease prognosis;Disease Progression;Early Diagnosis;endophenotype;Eye;Eye diseases;Foundations;Genetic;genetic architecture;genetic association;Genetic Determinism;Genetic Markers;Genetic Research;Genetic study;genome wide association study;genome-wide;Genomics;Genotype;Goals;health data;Heterogeneity;heterogenous data;high dimensionality;high risk;Image;Image Analysis;imaging genetics;improved;innovation;insight;International;Intervention;Joints;Knowledge;Learning;Machine Learning;machine learning algorithm;machine learning framework;machine learning method;Mining;Modeling;multiple data sources;novel;Ophthalmologist;Ophthalmology;Outcome;Pathogenesis;Patient Monitoring;Patients;personalized health care;Play;Positioning Attribute;Precision therapeutics;Prevention;progression risk;progressive neurodegeneration;rare variant;Reporting;Research;Retina;retinal imaging;Risk;Risk Factors;risk variant;Role;Scientific Advances and Accomplishments;Software Tools;Specialist;success;synergism;System;Systems Biology;Techniques;therapy development;Time;tool;Validation;Variant;wasting

PROJECT_TITLE: SCH: New Advanced Machine Learning Framework for Mining Heterogeneous Ocular Data to Accelerate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-VH-N(50)R]


ORG_CITY: LOUISVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: NARRATIVE  “Immunotherapeutic targeting of MIF-dependent chaperone activity”  Despite some very encouraging improvements in response rates and overall survival in late-stage melanoma patients receiving anti-PD-1/anti-CTLA-4 immune checkpoint blockade (ICB) immunotherapies, an unacceptably high percentage of treated patients remain unresponsive to these therapies. Studies proposed in this project application will investigate a unique metabolic transcriptional programming pathway that is governed by MIF-dependent chaperone activity. When therapeutically inhibited with a suicide antagonist discovered by our laboratory, highly immune suppressive myeloid lineage cells are converted to highly immune stimulatory myeloid cells in the tumor microenvironment which is sufficient to induce tumor rejection and increased survival.

PI_NAMEs: MITCHELL, ROBERT A (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acute;ALS patients;analog;angiogenesis;antagonist;anti-CTLA4;anti-CTLA4 antibodies;anti-PD-1;anti-PD1 antibodies;Antibody Therapy;Binding;Biological Assay;Biological Availability;cancer immunotherapeutics;cancer therapy;Cell Lineage;Cell surface;Cells;Clinic;Clinical;combinatorial;Communities;CTLA4 gene;Cuprozinc Superoxide Dismutase;cytokine;Data;Disease Progression;Disease Resistance;Drug Targeting;Effector Cell;endoplasmic reticulum stress;Functional disorder;Future;Gene Expression Profile;Genetic Transcription;Homeostasis;Human;Hypoxia;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immunogenic;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;Individual;Induced Neurons;inhibitor;Innate Immune Response;Laboratories;Lead;Lesion;Macrophage;Malignant - descriptor;Malignant Neoplasms;Melanoma;Melanoma patient;Metabolic;Metastatic Melanoma;Migration Inhibitory Factor;Mitochondria;mitochondrial dysfunction;Modality;Molecular Chaperones;Monoclonal Antibodies;monocyte;mouse model;mutant;Myelogenous;Myeloid Cell Activation;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;neovascularization;neurotoxicity;novel;Oral;overexpression;partial response;Pathway interactions;Patients;Phenocopy;Phenotype;Physiological;Play;polarized cell;prevent;programmed cell death protein 1;protein folding;Proteins;receptor;Respiration;response;Role;small molecule;small molecule inhibitor;Solid;Solid Neoplasm;stressor;Stromal Cells;Structure-Activity Relationship;Suicide;Superoxide Dismutase;T-Lymphocyte;Testing;Therapeutic;Tissue-Specific Gene Expression;Transgenic Organisms;tumor;tumor microenvironment;tumor progression;Tumor-associated macrophages;tumorigenic

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIO-D(01)Q]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: KANSAS CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PUBLIC HEALTH RELEVANCE To our knowledge, this is the first study prospectively designed to directly compare effectiveness and acceptability of menthol EC versus tobacco EC in menthol smokers transitioning to EC. We expect that both products will be acceptable and result in high rates of switching and improvements in tobacco-related health effects. Impact on the field will be significant. The study will provide critical data to the FDA to support restrictions on menthol EC that could slow youth and young adult initiation with no resulting negative impact on switching in adult combustible cigarette smokers transitioning to EC and no unintended consequences in a priority population of predominately African American and Latinx smokers.

PI_NAMEs: NOLLEN, NICOLE L (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: Adult;African American;Area;Blood Pressure;Cessation of life;Cigarette;Cigarette Smoker;combustible cigarette;Communities;compare effectiveness;Consumption;Country;craving;Data;Dependence;design;Disease;Effectiveness;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;ethnic minority;experience;Flavoring;follow-up;Gender;Generations;Harm Reduction;Health;health disparity;improved;Inhalation;interest;Intervention Studies;Latinx;Maintenance;Marketing;Measures;Menthol;minority communities;multidisciplinary;Nicotine;Observational Study;open label;Participant;Pattern;Population;primary outcome;Process;prospective;Prospective Studies;Public Health;public health relevance;public policy on tobacco;pulmonary function;Quality of life;Race;racial minority;Randomized;randomized, clinical trials;Research Priority;Respiratory Signs and Symptoms;Sample Size;Smoke;Smoker;Smoking;Sodium Chloride;System;Tobacco;tobacco flavor;tobacco toxicant;Tobacco use;trial comparing;vaping;Withdrawal;young adult;Youth

PROJECT_TITLE: The Impact of Menthol Flavoring on Switching in Adult Menthol Smokers


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Myocardial infarction is the most prevalent sequela of ischemic heart disease and is the leading cause of mortality in the world. Although progress has been made in understanding the endogenous regenerative potential of cardiomyocytes, the function of extracellular milieu in cardiac repair has yet to be unraveled. We will dissect the Nkx2.5 transcriptional pathway to uncover novel matrix proteins in zebrafish and will exploit innate pro-regenerative mechanisms to augment cell-based transplantation therapies for patients suffering from coronary artery disease.

PI_NAMEs: TARGOFF, KIMARA L (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Address;Adult;Atomic Force Microscopy;Biological Assay;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;cardiogenesis;Cardiomyopathies;cell motility;Cell Therapy;Cells;Cellular Infiltration;Cicatrix;congenital heart abnormality;Coronary Arteriosclerosis;Cues;Data;Dedications;Defect;Deposition;Development;Elastic Tissue;Elasticity;Elements;Embryo;Engraftment;Ensure;Epicardium;Exhibits;experimental study;extracellular;Extracellular Matrix;FBLN5 gene;fibulin;Fishes;Fostering;gain of function;Gene Activation;gene regulatory network;Genes;Genetic Transcription;Glycoproteins;healing;Heart;Heart failure;heart imaging;Heart Injuries;heart preservation;homeodomain;Human;Human Genetics;human induced pluripotent stem cells;human migration;Impairment;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Infarction;injured;Injury;innovation;insight;Invaded;Investigation;Ischemia;loss of function;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Methods;migration;Modeling;Modulus;Morbidity - disease rate;Morphogenesis;mortality;Movement;Mus;Mutate;Myocardial;Myocardial dysfunction;Myocardial Infarction;myocardial injury;Myocardial Ischemia;myocardial migration;Myocardium;Natural regeneration;neonatal mice;novel;Outcome;Pathway interactions;Patients;Pattern;Penetration;Play;preservation;Production;Prognosis;Proliferating;Proteins;Proteomics;Rattus;regeneration following injury;regeneration function;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regenerative response;regenerative therapy;Regulation;repaired;Research;Resolution;response;response to injury;Role;Signal Transduction;Slice;Stress;Testing;Therapeutic;Time;time use;Tissues;Titrations;transcription factor;transcriptome sequencing;Transducers;Transforming Growth Factor beta;transplantation therapy;Up-Regulation;Work;wound;Zebrafish

PROJECT_TITLE: Mechanisms of myocardial regeneration mediated by Nkx2.5 in zebrafish

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Drug abuse is an enormous public health challenge; human genetics studies have identified a significant genetic contribution to the risk of developing drug abuse. Rodent genetic studies are vital to understanding the molecular genetic basis of drug abuse, but are hampered by an incomplete catalogue of potentially causative genetic variants. In this project, we will examine two important but understudied sources of genetic variation: structural variants and tandem repeats.

PI_NAMEs: GYMREK, MELISSA ;PALMER, ABRAHAM A (contact);SEBAT, JONATHAN

PROGRAM_OFFICER_NAME: LOSSIE, AMY C

PROJECT_TERMS: addiction;Addictive Behavior;Address;autism spectrum disorder;Behavioral;behavioral phenotyping;Bioinformatics;Bipolar Disorder;Catalogs;causal variant;cohort;Communities;Complex;computerized tools;Computing Methodologies;Data;Data Set;Drug abuse;Gene Expression;Genetic;Genetic Polymorphism;Genetic study;genetic variant;Genetic Variation;genome sequencing;genome wide association study;genome-wide;genomic locus;Genotype;Height;Heritability;Human;Human Genetics;Human Genome;Hybrids;Inbred Mouse;Inbred Strain;Inbred Strains Rats;Inbreeding;Leadership;Malignant Neoplasms;Methods;model organism;Molecular Genetics;mouse genome;Mouse Strains;Mus;Mutation;nanopore;novel sequencing technology;Phenotype;Play;Population;Population Study;Public Health;Publishing;rat genome;Rattus;Recombinant Inbred Strain;Resources;Risk;Rodent;rodent genome;Role;Schizophrenia;Signal Transduction;single molecule;Single Nucleotide Polymorphism;Source;Surveys;Tandem Repeat Sequences;Technology;technology platform;trait;Variant;whole genome

PROJECT_TITLE: Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and Rats


ORG_CITY: CAMBRIDGE

ORG_NAME: NATIONAL BUREAU OF ECONOMIC RESEARCH

PHR: Project Relevance This research will contribute to public health by investigating the potential effects on tobacco use of two important public policies. These policies are complete bans on internet sales of e-cigarettes, and comprehensive bans on added flavors in e-cigarettes. The effects of new retailer penalties for the sale of e- cigarettes to underage buyers will also be investigated.

PI_NAMEs: SAFFER, HENRY  (contact)

PROJECT_TERMS: Address;Adolescent Risk Behavior;Adoption;Adult;adverse outcome;Affect;Age;Area;Behavioral Risk Factor Surveillance System;Cigarette;cognitive development;combustible tobacco;Consumption;Cotinine;Data;Drug usage;econometrics;Effectiveness;Electronic cigarette;electronic cigarette use;Electronic Nicotine Delivery Systems;Future;Health;Health Promotion;Health Surveys;Individual;Internet;Intervention;Knowledge;Laws;Legal;Licensing;Life Cycle Stages;Literature;Measures;Monitor;National Health Interview Survey;Natural experiment;Nervous System Trauma;Nicotine;Nicotine Dependence;nicotine exposure;nicotine use;Outcome;Pattern;Policies;Population Assessment of Tobacco and Health;Prevention;Public Health;Public Policy;Quasi-experiment;Regulation;Research;Risk;Sales;Smokeless;Smokeless Tobacco;smokeless tobacco use;Smoker;Smoking;smoking abstinence;smoking cessation;Surgeon;Surveys;Suspensions;System;tobacco products;tobacco regulation;Tobacco use;uptake;vaping;Variant;virtual;young adult;Youth

PROJECT_TITLE: The Effects of New E-cigarette Internet Sales Bans and E-cigarette Flavor Bans on Tobacco Use by Youth, Young Adults and Adults


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: STOCKTON

ORG_NAME: UNIVERSITY OF THE PACIFIC-STOCKTON

PHR: Project Narrative: The proteins known as KV7.1, KCNE1 and NaVβ1 are found in different types of cells, including those in the heart and neurons in the brain. We have recently discovered that NaVβ1 exerts an inhibitory effect on the activity of KV7.1 counterbalancing the well-known positive modulatory effect of KCNE1. This study will investigate how alteration in the balance of the actions of KCNE1 and NaVβ1 can lead to faulty KV7.1 activity potentially causing in encephalopathies and cardiac arrhythmias.

PI_NAMEs: VILLALBA-GALEA, CARLOS ALBERTO (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Affect;Amino Acids;amino group;Architecture;Arrhythmia;Auditory system;Brain;Cardiac Myocytes;Cell membrane;cell type;Cells;Cessation of life;Characteristics;Clinical;Complex;Data;deafness;Dependence;Disease;disease-causing mutation;Encephalopathies;Engineering;Equilibrium;Ethers;Event;Exposure to;extracellular;Family;Family member;Genes;Glycine;Hearing problem;Heart;Human;Kinetics;Lead;Leucine;Link;Literature;Membrane;Membrane Potentials;Modeling;Modification;Molecular;Muscle Cells;Mutate;Mutation;Neurons;Nonsense Mutation;novel;Oocytes;Organ;Outcome;Periodicity;Potassium;Predisposition;prevent;Process;Protein Isoforms;Proteins;Recovery;RNA Splicing;Signal Transduction;Sodium;Testing;Transmembrane Domain;Ventricular;virtual;voltage;Work;Xenopus oocyte

PROJECT_TITLE: KCNE1 as a molecular shield of KV7.1


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: NARRATIVE The opioid crisis (e.g., overdose deaths) has worsened significantly during the COVID-19 pandemic, despite a decrease in the number of prescriptions for opioids and relaxation of prescribing practices for medication assisted treatment (e.g., buprenorphine). However, the number of prescriptions for (and the off-label use of) gabapentinoids (pregabalin [Lyrica®] and gabapentin [Neurontin®]) is soaring with gabapentinoids increasingly detected in drug overdose victims, raising serious concerns about the health risks of this class of drugs. By characterizing the contribution of gabapentinoids to the abuse-related and toxic effects of opioids, these studies will help guide regulatory agencies and practitioners confront this unexplored and underappreciated misuse of FDA-approved medications that is contributing to the opioid crisis. 1

PI_NAMEs: HIRANITA, TAKATO  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: Accounting;Address;Adverse effects;Advocacy;American;Area;Attention;Attenuated;Autopsy;Behavior;Biological Assay;Breathing;Buprenorphine;Cessation of life;Classification;Clinical;Clinical Trials;clinically relevant;Cocaine;cocaine self-administration;Convulsions;COVID-19 pandemic;Data;Dependence;Development;drug discrimination;Drug usage;epidemiologic data;experience;FDA approved;Female;Fentanyl;fentanyl seeking;fentanyl self-administration;gabapentin;General Population;Health;Heroin;Individual;Life Expectancy;Literature;male;medication-assisted treatment;Morbidity - disease rate;mortality;mu opioid receptors;Naloxone;naloxone dosing;non-opioid analgesic;off-label use;Opiate Addiction;Opioid;Opioid agonist;opioid epidemic;opioid exposure;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid withdrawal;Overdose;overdose death;pandemic disease;Parents;Patients;Pharmaceutical Preparations;Physical Dependence;Pilot Projects;Policies;Predisposition;pregabalin;prescription opioid;pressure;Procedures;Public Health;Rattus;Recording of previous events;Relaxation;Reporting;Research;Research Personnel;Research Project Grants;respiratory;response;Risk;Risk Assessment;Risk Factors;Schedule;Seizures;Self Administration;sex;Stimulus;Substance Use Disorder;Testing;Time;Toxic effect;Toxicology;United States National Institutes of Health;Ventilatory Depression;Withdrawal

PROJECT_TITLE: Gabapentinoid/opioid mixtures: abuse and toxicity

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Regenerative Medicine;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SYRACUSE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative Deep within the human brain lies a reservoir of stem cells capable of generating new neurons throughout life. We will build a molecular map of all cell types within this reservoir, which will allow us to understand how increased presence of immune cells in schizophrenia support or hinder the development of new neurons. This work will bring us closer to unlocking the potential of these stem cells to treat both psychiatric and neurological brain diseases in the future. .

PI_NAMEs: WEICKERT, CYNTHIA SHANNON (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Adult;adult neurogenesis;Anatomy;angiogenesis;Anti-Inflammatory Agents;Astrocytes;Blood;Blood - brain barrier anatomy;Bone Marrow;Brain;Brain Diseases;brain parenchyma;Brain region;brain research;Cell Maintenance;Cell Proliferation;cell type;Cells;Characteristics;comparison control;Complex;cytokine;density;Development;Diagnosis;Endothelial Cells;Exposure to;Future;Gene Expression Profile;Genetic Transcription;Grant;Heterogeneity;Human;ICAM1 gene;Immune;Impairment;Inflammation;Inflammatory;Interneurons;Label;Laboratories;lateral ventricle;Life;Macrophage;Maps;Microglia;migration;Molecular;Molecular Profiling;monocyte;Morphology;Nature;nerve stem cell;neural;neurogenesis;Neuroglia;neuroinflammation;Neurologic;Neuronal Differentiation;Neurons;neuropathology;Pathway interactions;Persons;Phenotype;Population;Positioning Attribute;Proliferating;Proteins;Resolution;response;Role;Route;Schizophrenia;Signaling Molecule;stem;stem cell biomarkers;stem cells;Subependymal;Tight Junctions;Transcript;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Neuroinflammation and Neurogenesis in Schizophrenia

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Narrative The importance of T cells to immune responses has led to many measures of their strength of interaction with antigen. Our studies will translate these measures along with functional phenotype into the bond lifetime and affinity between the T cell receptor and antigen.

PI_NAMEs: EVAVOLD, BRIAN D (contact);WILLIAMS, MATTHEW A

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: 3-Dimensional;Address;Affect;Affinity;Antigen-Presenting Cells;Antigens;Applications Grants;Automobile Driving;Biological Assay;biophysical properties;Biophysics;CD8-Positive T-Lymphocytes;Cell membrane;Cell Physiology;Cell surface;Cell Survival;Cells;Cellular biology;complementarity-determining region 3;Data;Development;driving force;Engineering;Equation;functional outcomes;Goals;IL17 gene;IL2RA gene;Immune response;In Situ;Infection;Infectious Agent;Influenza;Interferon Type II;Interleukin-10;Interleukin-2;Joints;Knowledge;Ligands;Listeria;Lymphocytic choriomeningitis virus;Measures;Mediating;Membrane;Memory;Methods;MHC antigen;MHC Interaction;microbial genome;Mind;Modeling;Mus;novel;Outcome;OX40;Peptide/MHC Complex;Peptides;Peripheral;Phenotype;Plasmodium;Play;programmed cell death protein 1;Proteins;Proxy;Publishing;Receptor Signaling;Regulatory T-Lymphocyte;Reporter;response;Role;segregation;Signal Transduction;Surface;T cell response;T-Cell Receptor;T-Lymphocyte;TCR Activation;Technology;Thymocyte Development;Tissues;Translating;two-dimensional;Work

PROJECT_TITLE: Deconstructed T cell antigen recognition: Separation of affinity from bond lifetime

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(90)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Physical Despite aims evidence-based based inactivity is prevalent and chronic diseases impact racial/ethnic minorities at a disproportionate rate. the availability of evidence-based physical activity interventions, few go to scale. The proposed study to develop and test implementation strategies to accelerate the uptake, spread, and sustainment of an physical activity intervention to improve health outcomes of underserved communities in faith- organizations.

PI_NAMEs: ARREDONDO, ELVA M (contact)

PROGRAM_OFFICER_NAME: MASTERSON, MARY YAA SEDEGAH

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Advocate;attentional control;Behavior;behavior change;Body mass index;Cancer Control;Cardiovascular Diseases;cardiovascular risk factor;Cessation of life;Chronic Disease;Church;Communities;community collaboration;Community Health Aides;community setting;contextual factors;Control Groups;Data;design;Diabetes Mellitus;Effectiveness;effectiveness/implementation trial;empowerment;ethnic minority;evidence base;Evidence based intervention;exercise intervention;expectation;experience;experimental study;Faith;Faith-based organization;follow-up;Gender Role;Guidelines;Health;Health Promotion;Hybrids;implementation framework;implementation strategy;improved;Individual;innovation;Intervention;Latina Population;Latino;Latino Population;Life Style;Maintenance;Malignant Neoplasms;member;Methods;moderate-to-vigorous physical activity;National Cancer Institute;Obesity;Organizational Change;organizational climate;Outcome;Pathway interactions;Personal Satisfaction;Physical activity;Physical activity scale;physical inactivity;Population;Practical Robust Implementation and Sustainability Model;prevent;program dissemination;programs;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Research;Risk Factors;Role;scale up;social culture;sustainability framework;tailored messaging;Testing;Training;underserved community;uptake

PROJECT_TITLE: Enhancing capacity in faith-based organizations to implement and sustain multilevel innovations to improve physical activity


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: EDINBURG

ORG_NAME: UNIVERSITY OF TEXAS RIO GRANDE VALLEY

PHR: Pancreatic adenocarcinoma shows increased rate of ribosome biogenesis and desmoplastic tumor microenvironment resulting in poor therapeutic response. Thus, novel strategy is required to inhibit ribosome biogenesis and depletion of desmoplastic TME for the management of advanced pancreatic cancer. This study for the first time will establish a new therapeutic approach for the treatment of advanced pancreatic tumor growth via targeting ribosome biogenesis and desmoplastic tumor by combination therapeutic regimen of RNA polymerase I and hyaluronan inhibitor (BMH-21+ 4-Methylumbelliferone).

PI_NAMEs: HAFEEZ, BILAL BIN (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: 3-Dimensional;4-methylumbelliferone;Adenocarcinoma;advanced pancreatic cancer;Affect;anti-cancer;antitumor effect;Biogenesis;Biological Assay;bioluminescence imaging;cancer cell;Cancer Etiology;cancer therapy;Catalytic Domain;Cell Cycle;Cell Physiology;Cells;Cessation of life;Chemoresistance;Chemosensitization;chemotherapy;Clinic;Clinical;Complex;Data;Desmoplastic;Development;Disease Progression;Distant;DNA Polymerase I;effector T cell;Environment;Erlotinib;Extracellular Matrix;fibrillarin;Fibroblasts;Fluorouracil;Foundations;Future;gemcitabine;Grant;Growth;Human;Hyaluronan;Hyaluronic Acid;Immunologic Surveillance;improved;In Vitro;Infiltration;inhibitor;Injections;Invaded;KRASG12D;Liver;Luciferases;Lung;lymph nodes;Malignant neoplasm of pancreas;Malignant Neoplasms;Mesentery;Migration Assay;Molecular;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel strategies;novel therapeutic intervention;novel therapeutics;Nude Mice;Organ;Paclitaxel;Pancreas;Pancreatic Adenocarcinoma;pancreatic cancer cells;pancreatic cancer model;pancreatic neoplasm;pancreatic stellate cell;patient derived xenograft model;Pattern;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Phosphotransferases;preclinical study;prevent;Process;Production;Property;PubMed;Regimen;Repression;Research;Resistance;response;Retroperitoneal Space;Ribosomes;RNA Polymerase I;RNA Polymerase Inhibitor;Signal Transduction;spheroids;Testing;Therapeutic;Therapeutic Effect;Time;Transgenic Mice;translational impact;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Tissue;tumor xenograft;United States;United States National Institutes of Health;uptake;Xenograft procedure

PROJECT_TITLE: Targeting ribosome biogenesis and desmoplastic tumor microenvironment for the treatment of advanced pancreatic cancer


NIH_SPENDING_CATS: Aging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Heart Disease;Stroke

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Despite the absence of supporting evidence, treatment guidelines and prescription drug insurance formularies typically assume that individual drugs within medication classes are equally effective and equally safe. Yet, when incorrect, these assumptions expose patients to suboptimal treatments and clinical harms, particularly older adults, who are disproportionately affected by chronic conditions and take more prescription medications than any other population. Taking advantage of natural experiments created by the design of the Medicare prescription drug benefit, the proposed study will use existing data on more than 22 million Medicare beneficiaries to answer key questions about the comparative benefits and harms among drugs within each of four therapeutic classes widely-used among older adults.

PI_NAMEs: GERHARD, TOBIAS  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Affect;Amputation;Anticoagulants;Area;Atherosclerosis;atorvastatin;Atrial Fibrillation;Atrial Flutter;beneficiary;Brain hemorrhage;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cessation of life;Characteristics;Chronic;Clinical;clinical effect;Clinical Medicine;clinically relevant;comparative;comparative effectiveness study;Cost Savings;Data;data resource;design;Dipeptidyl Peptidases;Disease;drug development;Drug Insurance;Drug Prescriptions;Drug usage;economic implication;economic incentive;Economics;Enrollment;Ensure;Event;evidence base;Face;financial incentive;Formularies;Future;Glucose;Head;Healthcare Systems;Heart failure;high risk;Hydroxymethylglutaryl-CoA Reductase Inhibitors;improved;indexing;Individual;inhibitor;innovation;Ischemic Stroke;Knee;Knowledge;Light;Manufacturer;Marketing;Measures;Medical Records;Medicare;Medicare claim;Meta-Analysis;Methodology;Methods;Natural experiment;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;older adult;Oral;Outcome;Outcome Measure;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;Privatization;Process;Public Health;Randomized, Controlled Trials;Research;research and development;Research Design;Risk;rosuvastatin;Secondary Prevention;Sodium;Stroke prevention;stroke risk;Structure;symporter;Therapeutic;Therapeutic Equivalency;treatment guidelines;Uncertainty;Uninsured Medical Expense;Update;Validation;Variant;Withdrawal;Work

PROJECT_TITLE: A Novel Approach to Examine Within-Class Therapeutic Exchangeability of Medications

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]