NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Digestive Diseases;Genetics;Obesity;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_DEPT: SURGERY

PHR: Diminished first-phase insulin secretion is the early and detrimental defect in type 2 diabetes. The preliminary data show an increase in first-phase insulin secretion and improved glucose tolerance to supranormal levels following exocrine pancreas ablation. This proposal aims to understand the dramatic increase in the first-phase insulin secretion following the exocrine tissue ablation, test the effect of exocrine pancreas loss in mice models of hyperglycemia, and identify the underlying causes of the improved insulin secretion that accompany loss of the exocrine tissue.

PI_NAMEs: SALEH, MOHAMED  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Acetic Acids;Acinar Cell;Acinus organ component;Adult;Adverse effects;Affect;allotransplant;Anabolism;Animals;Attention;Beta Cell;Biphasic Pattern;blood glucose regulation;cancer cell;Cause of Death;Cell membrane;Cell Physiology;Cellular biology;Characteristics;Closure by clamp;Coculture Techniques;Communication;Cytoplasmic Granules;Data;Defect;design;Development;Diabetes Mellitus;Diagnosis;Diphtheria Toxin;diphtheria toxin receptor;Duct (organ) structure;Economic Burden;economic cost;Elastases;Endothelial Cells;Enzymes;Excision;Exocrine pancreas;Exocytosis;Financial Hardship;Funding;gene therapy;Genetic Models;Genetic Transcription;Glucose;glucose tolerance;Glucose tolerance test;Goals;Health;High Fat Diet;Human;Hyperglycemia;Hypoglycemia;Image;impaired glucose tolerance;improved;In Situ;in vivo;Infusion procedures;Institution;Insulin;insulin granule;insulin secretion;insulin sensitivity;Intercellular Fluid;Intervention;islet;Islets of Langerhans;knock-down;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;nerve supply;Non-Insulin-Dependent Diabetes Mellitus;nonhuman primate;novel therapeutics;Obesity;Operative Surgical Procedures;Pancreas;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;Pancreatic enzyme;Pathway interactions;Patients;Peptide Hydrolases;peripheral blood;Phase;Phenotype;Physiological;Physiology;Prediabetes syndrome;Preparation;Prevalence;promoter;radiological imaging;Reporting;Research;Research Personnel;Resources;response;Reverse Transcriptase Polymerase Chain Reaction;Rodent;selective expression;Serine Proteinase Inhibitors;Signal Transduction;small hairpin RNA;Streptozocin;Supervision;Surgical Models;Testing;therapeutic target;Tissues;trafficking;transcriptome sequencing;Translations;Transplantation;tumor;United States;Universities;Viral;Viral Genes;Work

PROJECT_TITLE: Loss of the Exocrine Pancreas Improves Glucose Tolerance and Insulin Secretion

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: EUGENE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE  This project provides a comprehensive picture of social, neural, and hormonal changes and their relationship to mental health problems in mid-to-late adolescence, a period of peak symptom severity and diagnosis rates for internalizing disorders and self-harm among girls. Understanding the core mechanisms associated with these problems across adolescence will not only enhance our knowledge of how mental illness develops in vulnerable individuals, but also enable translation of this knowledge for developmentally targeted approaches to early intervention and prevention. This project seeks to inform clinical intervention and prevention approaches that target close peer relationships and leverage biological insights to improve adolescent mental health, specifically through the lens of investigating emergence and recurrence of internalizing disorders in adolescent girls.

PI_NAMEs: PFEIFER, JENNIFER HOPE (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Acceleration;Address;Adolescence;Adolescent;adolescent mental health;Affect;Age;Aggressive behavior;Anxiety;Area;Behavior;Behavioral;Biological;Biological Assay;Biological Factors;Biological Markers;Biological Process;Biology;biomarker identification;biopsychosocial;Brain;Buffers;Clinical;cohort;Communities;Conflict (Psychology);Data;data acquisition;Data Sources;design;Development;Diagnosis;Diagnostic;diaries;Disease;dynamic system;early adolescence;Early Intervention;Enrollment;experience;Feeling;Female Adolescents;Fostering;Frequencies;Friendships;Funding;Future;girls;Gonadal Steroid Hormones;Hormonal;Hormonal Change;Hormones;improved;Individual;innovation;insight;interest;Intervention;Interview;intimate behavior;Investigation;Knowledge;knowledge translation;Laboratories;lens;life span;Longitudinal Studies;longitudinal, prospective study;Measures;Medial;Mediating;Mental Depression;Mental disorders;Mental Health;Modality;Motion;multimodality;National Institute of Mental Health;Nature;neural;neurodevelopment;novel;Patient Self-Report;peer;Personal Satisfaction;personalized intervention;Phase Transition;Phenotype;Play;Populations at Risk;Prefrontal Cortex;Prevention;Prevention approach;Process;prospective;psychosocial;pubertal timing;Puberty;Public Health;Questionnaires;racism;Recording of previous events;Recurrence;recurrent depression;Research;resilience;Risk;Risk Marker;risk prediction;Role;rumination;Sampling;Self Disclosure;Self Perception;Self-Injurious Behavior;Series;Severities;Sexual Maturation;Shapes;social;Social Change;social cognition;Social Development;Social Functioning;Social Processes;Societal Factors;socioeconomic disparity;stress management;Stressful Event;Structure;Symptoms;Time;Transact;translational neuroscience;Ventral Striatum;Visit;Vulnerable Populations

PROJECT_TITLE: A prospective longitudinal study of transactional associations between social, neural, and hormonal changes and adolescent girls' mental health trajectories

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative. People living with HIV and non-communicable diseases (NCDs) have a high mortality post-discharge in Sub-Saharan Africa. This is in part due to disintegrated linkages of care post-admission for HIV/NCD. We will address the HIV/NCD care cascade after hospitalization to reduce adverse outcomes post-discharge.

PI_NAMEs: KANYAMA, CECILIA  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: acceptability and feasibility;Address;Admission activity;Adopted;Adoption;Adult;adverse outcome;Africa South of the Sahara;antiretroviral therapy;Area;Awareness;Behavioral;burden of illness;cardiometabolism;Caregivers;Caring;Cessation of life;Clinical;clinical practice;Communities;community based care;Community Outreach;comorbidity;Complex;Continuity of Patient Care;Control Groups;cost;Data;Diabetes Mellitus;Discharge Plannings;Disease;Disease Management;Effectiveness;Enrollment;Evaluation;evidence base;experience;feasibility testing;Focus Groups;follow-up;Goals;Healthcare Systems;Heart failure;HIV;Home;hospital readmission;Hospitalization;Hospitals;Hotlines;Human immunodeficiency virus test;hypertensive;implementation framework;implementation science;improved;Income;Individual;Inflammation;innovation;Inpatients;integrated care;Intervention;Interview;Lead;Length of Stay;low and middle-income countries;Malawi;Mediating;Meta-Analysis;Methods;Modeling;mortality;neglect;Nurses;Opportunistic Infections;Outcome;Outpatients;outreach program;Participant;Patient Admission;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmacists;Phase;Physician Assistants;pilot test;Polypharmacy;posthospitalization care;Preparation;programs;provider communication;readmission risk;recruit;Research;Research Personnel;research study;Resources;Role;Surveys;Viral;Virus;Visit

PROJECT_TITLE: Adaption of the Transition of Care Model for Post-Discharge HIV-NCD care in Malawi

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Rare Diseases;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Tick-borne rickettsial diseases causing human ehrlichiosis and human anaplasmosis have become a growing public health concern over the past three decades throughout the USA and many parts of the world. In this proposal, we will work to develop attenuated vaccines to protect against the pathogen infections into the blood stream or from tick transmission; the two possible means by which tick-borne rickettsial pathogens cause infections in people.

PI_NAMEs: GANTA, ROMAN R. (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Adaptive Immune System;Address;Advanced Development;Anaplasma;Anaplasma phagocytophilum;Anaplasmataceae;Anaplasmosis;antiporter;Attenuated;Attenuated Vaccines;attenuation;Bacteriophages;Blood;Canis familiaris;chronic infection;Code;Data;deep sequencing;Development;Diagnosis;Disease;effective intervention;Ehrlichia;Ehrlichia canis;Ehrlichia chaffeensis;Ehrlichia ewingii;Ehrlichiosis;Ensure;Epitopes;experimental study;Family;Family member;Foundations;gene function;Gene Mutation;Genes;Goals;granulocyte;Health;Homologous Gene;Human;Immune response;Immunity;Immunologic Memory;Infection;innovation;Insertion Mutation;Intervention;member;Membrane Proteins;Methods;microbial;Modeling;monocyte;Mutagenesis;mutant;Mutation;Organ;pathogen;Pathogenesis;Patients;Persons;Physiological;Positioning Attribute;prevent;Proteins;Proteome;Public Health;Publishing;Reporting;Research;Resources;Rickettsia;Rickettsia Infections;Risk;RNA;Route;Sepsis;Stream;Structure;System;Testing;tick transmission;tick-borne;Tick-Borne Diseases;Tick-Borne Infections;tick-borne pathogen;Ticks;tool;transcriptome;Vaccination;vaccine development;Vaccines;Variant;Vertebrates;Work

PROJECT_TITLE: Vaccines Against Ehrlichia and Anaplasma Species Infections


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: AMHERST

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Project Narrative This proposal is aimed at understanding how key regulators (transcription factors) interact with and modify the epigenetic landscape and promote retinal ganglion cell differentiation. The findings from the proposed experiments will lead to further insights into the molecular basis underpinning the generation of the cellular diversity in the retina and offer guidance for developing strategies to treat degenerative retinal diseases.

PI_NAMEs: MU, XIUQIAN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Amino Acids;Antibodies;ATOH7 gene;Binding;Binding Sites;Cell Differentiation process;cell fate specification;Cell Lineage;cell type;Cells;Central Nervous System;Clustered Regularly Interspaced Short Palindromic Repeats;Data;differential expression;E-Box Elements;Ectopic Expression;Embryonic Development;Enhancers;Epigenetic Process;Event;Experimental Designs;experimental study;Gene Activation;Gene Expression;Generations;Genes;genome editing;Genomics;Immunofluorescence Immunologic;Immunohistochemistry;In Situ Hybridization;in vivo;Individual;insight;Knock-in Mouse;Knock-out;Knowledge;Maps;Mediating;Molecular;mouse genetics;Multipotent Stem Cells;mutant;Mutation;Phenotype;Photoreceptors;Play;programs;Research;Retina;Retinal Degeneration;Retinal Ganglion Cells;retinal progenitor cell;Role;sample fixation;Shapes;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;SOX11 gene;SOX4 gene;Specificity;Stains;Surveys;Techniques;Testing;Therapeutic;Time;transcription factor;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Regulatory mechanisms for retinal ganglion cell genesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-M(02)M]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: PROJECT NARRATIVE Adherence to combination antiretroviral therapy is required to suppress patient HIV viral loads, which is essential to both optimize individual health and prevent onward transmission of HIV. We therefore propose to investigate a novel urine-based point-of-care assay that detects the presence of tenofovir, the backbone of most antiretroviral regimens worldwide, to detect inadequate adherence and support adherence. Our objectives are to study the ability of this new assay to identify patients in need of adherence support and its usefulness, feasibility and acceptability when used to reinforce and support treatment adherence.

PI_NAMEs: GANDHI, MONICA ;ORRELL, CATHERINE ;VAN ZYL, GERT UVES (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: acceptability and feasibility;Adherence;Aftercare;Agreement;Anti-Retroviral Agents;Antibodies;antiretroviral therapy;arm;Biological Assay;Blood;California;care systems;Caring;Client satisfaction;Clinic Visits;Clinical;compliance behavior;cost;Counseling;Cross-Sectional Studies;design;detection assay;Development;Diphosphates;Drug resistance;Dryness;Enrollment;Failure;Feedback;follow-up;Grant;Guidelines;Hair;Health;Health Personnel;high risk;HIV;HIV-1;Immunoassay;Immunologics;improved;improved outcome;Individual;instrumentation;Intervention;intervention participants;Interview;Laboratories;Lamivudine;Length of Stay;Measures;Modernization;Monitor;novel;Outcome;Participant;Patient Compliance;Patient Recruitments;Patient Selection;Patient Self-Report;Patients;Perception;Pharmaceutical Preparations;Pharmacy facility;Plasma;point of care;point of care testing;prevent;primary care clinic;primary outcome;Process;Provider;Psychological reinforcement;Questionnaires;Ramp;randomized, controlled study;Randomized, Controlled Trials;Rapid diagnostics;rapid test;Recommendation;Regimen;Resistance;Resource-limited setting;Risk;Sampling;San Francisco;Scientist;secondary outcome;Service delivery model;Services;side effect;South Africa;South African;Specificity;Spottings;standard of care;success;Supervision;support tools;Surveys;Technology;Tenofovir;Testing;therapy adherence;Time;tool;transmission process;treatment adherence;treatment arm;Treatment Failure;Underrepresented Populations;Universities;Urine;Vertebral column;Viral load measurement;Viral Load result;viral resistance;Visit

PROJECT_TITLE: Urine tenofovir point-of-care test to identify patients in need of ART adherence support


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Rehabilitation;Stroke

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Due to extremely limited infrastructure and healthcare resources, motor and cognitive impairments in general and HIV-Associated Neurocognitive Disorders (HAND) in particular often go undiagnosed in people living with HIV (PLWH) and non-communicable diseases (NCDs) in Low and Middle Income Countries (LMICs). Novel and affordable technology-based strategies are needed to offer both evaluation and treatment. In collaboration with partners in Botswana, where the prevalence of both HIV and NCDs is high, we seek to determine the feasibility, acceptability and preliminary efficacy of an innovative and affordable robot-assisted solution to objectively assess and diagnose motor and cognitive impairments after HIV and HIV-Stroke.

PI_NAMEs: JOHNSON, MICHELLE J. (contact)

PROJECT_TERMS: Activities of Daily Living;Address;Affect;Africa;Africa South of the Sahara;African;Age;AIDS dementia;antiretroviral therapy;base;Botswana;Cardiovascular Diseases;Caring;Central Nervous System;Classification;Clinical;Cognitive;cognitive disability;cognitive function;cognitive testing;Collaborations;comorbidity;computerized;cost;cost effective;Country;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;disability;Disease;Education;Engineering;Environment;Evaluation;exergame;Face;Freedom;Gait;Goals;Grant;haptics;Health;Healthcare;Hepatitis C;High Prevalence;HIV;HIV Seronegativity;HIV-associated neurocognitive disorder;Hospitals;Human;Human Resources;Hypertension;Impaired cognition;Individual;Infection;Infrastructure;innovation;International;lifestyle factors;low and middle-income countries;manufacture;Measures;Meta-Analysis;Modeling;Motor;Motor disability;motor impairment;Nervous System Trauma;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Neurologic;neurological rehabilitation;Neuropsychology;novel;novel strategies;Participant;Patients;Pennsylvania;Persons;Prevalence;programs;prototype;Quality of life;recruit;Rehabilitation therapy;rehabilitative care;repaired;Reporting;Research Personnel;Resources;Risk;Robot;robot assistance;robot rehabilitation;robot therapy;robotic system;Robotics;screening;Screening procedure;Sensitivity and Specificity;Series;sex;Standardization;Stroke;stroke risk;stroke survivor;Substance abuse problem;Supervision;System;systematic review;Target Populations;Technology;technology platform;Testing;Time;Tobacco;Tobacco use;tool;Training;treatment program;Uganda;Universities;Upper arm;usability;Validation;Validity and Reliability;Vascular Diseases;Viral Load result;Work

PROJECT_TITLE: Affordable Robot-Based Assessment of Cognitive and Motor Impairment in People Living with HIV and HIV-Stroke

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Cytochrome P450 2E1 (CYP2E1) is a unique mammalian enzyme that can participate in normal biochemical metabolic reactions and can also contribute to cellular damage through production of reactive metabolites. We are studying this paradox using different approaches including cell culture and animal models. I propose to follow up on my recent discoveries that CYP2E1 can have different effects in different compartments of the cell, and study how, why, and when its activity is important for human health.

PI_NAMEs: HARTMAN, JESSICA HELENE (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acetaminophen;Acetone;Address;Alcoholic liver damage;Animal Model;Biochemical;Cell Compartmentation;Cell Culture Techniques;cell injury;Cells;CYP2E1 gene;Cytochrome P450;diet-induced obesity;endoplasm;Endoplasmic Reticulum;Enzymes;Epilepsy;Ethanol;Fatty Acids;follow-up;Genetic;Goals;Health;Human;Hydroxylation;improved;ketogenic diet;Knock-out;Lipids;Liver;liver repair;loss of function mutation;Metabolic;Metabolism;Mitochondria;Mixed Function Oxygenases;Modality;non-alcoholic fatty liver disease;Open Reading Frames;Organelles;pandemic disease;Pharmaceutical Preparations;pharmacologic;Phenotype;polypeptide;Population;Positioning Attribute;Post-Translational Regulation;posttranscriptional;Production;programs;Pyruvaldehyde;Reaction;Reagent;Recommendation;Regulation;Reporting;Research;Resources;Rodent Model;Role;Stress;therapeutic target;Tissues;Toxic effect;Variant;Work

PROJECT_TITLE: Regulation and Consequences of Cytochrome P450 2E1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(55)R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This proposal will explore the role of mitochondria and oxidative stress in astrogliosis associated with acquired epilepsy. The major goal is to investigate the role of mitochondrial redox processes in initiating seizure-induced astrogliosis. The studies can have a sustained impact on the field and result in novel metabolism-based therapies to control neuroinflammation in epilepsy.

PI_NAMEs: PATEL, MANISHA N (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: acquired epilepsy;Adult;Antioxidants;Astrocytes;astrogliosis;Award;Bioenergetics;Brain;Brain Injuries;Calcium;calmodulin-dependent protein kinase II;Cell Death;Chronic;clinical application;comorbidity;Convulsants;Cysteine;cytokine;Deacetylase;Embryo;Epilepsy;Functional disorder;Generations;Glial Fibrillary Acidic Protein;Glucose;Goals;Image;Impaired cognition;In Vitro;in vivo;Inflammation;Injury;innovation;kainate;Laboratories;Literature;Mass Spectrum Analysis;Mediator;Messenger RNA;Metabolic;Metabolic dysfunction;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Modification;mouse model;mRNA Expression;Mus;mutant;neuroinflammation;neuronal excitability;Neurons;Neurotransmitters;novel;novel therapeutics;Oxidants;Oxidation-Reduction;Oxidative Stress;Pilocarpine;Post-Translational Protein Processing;Process;Prosencephalon;protein expression;Proteins;Reactive Oxygen Species;Regulation;Role;Seizures;Sirtuins;Site;SOD2 gene;Status Epilepticus;Testing;therapeutic target;tool;two-photon;Up-Regulation

PROJECT_TITLE: Mitochondrial Mechanisms of Astrogliosis in Epilesy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HL

ED_INST_TYPE: OVERALL MEDICAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Neurosciences;Prevention;Sleep Research

ORG_CITY: PORTLAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: Project Narrative There are clear day/night patterns in the timing of adverse cardiovascular events, including myocardial infarction, stroke and sudden cardiac death, which all strike most frequently in the morning. This research program will examine how circadian rhythms in the cardiovascular system, behavior-related alterations in the cardiovascular system, and an individual’s own vulnerability may interact to affect risk for adverse cardiovascular events. This research will lay the groundwork for optimizing timed therapies for cardiovascular diseases.

PI_NAMEs: SHEA, STEVEN A (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adrenergic Agents;Adult;Adverse event;Affect;Autonomic nervous system;Behavior;Behavioral;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular disorder therapy;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cells;circadian;circadian pacemaker;Circadian Rhythms;Clinical;Clinical Research;Discipline of Nursing;Drug Targeting;Equilibrium;Event;Exercise Physiology;experience;Funding;Grant;Heart;Human;Hypertension;improved;Individual;laboratory experiment;Lead;Left ventricular structure;Medicine;middle age;multidisciplinary;Myocardial Infarction;Obstructive Sleep Apnea;Paper;Pattern;Physiological;Population;Positron-Emission Tomography;postsynaptic;Posture;preclinical study;Predisposition;presynaptic;programs;Protocols documentation;Publications;Research;Research Personnel;response;Rest;Risk;Risk Factors;Services;Sleep;Stress;stressor;Stroke;sudden cardiac death;System;Time;Tissues;tool;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Endogenous circadian mechanisms underlying cardiovascular risk


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: PROJECT NARRATIVE Immunotherapies are new medications used treat a variety of cancers. Treatment with immunotherapies, such as checkpoint inhibitors, result in toxicity to the kidneys by activating the immune system. We plan to study how immunotherapies affect the immune system and damage the kidneys and ways to identify this toxicity early in cancer treatment.

PI_NAMEs: ALEKSUNES, LAUREN M;JOY, MELANIE S (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;acute toxicity;Affect;Animal Model;anti-cancer;anti-CTLA4 antibodies;anti-PD1 antibodies;Antitumor Response;Biological;Biological Markers;Biological Products;Biology;Biopsy;Cancer Center;Cancer Model;Cancer Patient;Cancer Survivor;cancer therapy;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;checkpoint therapy;Chronic Kidney Failure;circulating biomarkers;Clinical;Clinical Oncology;clinical practice;Combined Modality Therapy;Creatinine;CTLA4 gene;Data;Detection;Development;Diagnostic;drug development;drug disposition;Drug Exposure;Drug Kinetics;Drug Modelings;Evaluation;Exhibits;feasibility testing;follow-up;Glomerular Filtration Rate;Glomerulonephritis;Goals;Guidelines;Hematopoietic;Histopathology;Human;humanized mouse;Immune;Immune checkpoint inhibitor;immune modulating agents;Immune Sera;Immune system;immune-related adverse events;Immunologic Surveillance;Immunological Models;Immunology;Immunomodulators;Immunophenotyping;Immunotherapy;immunotoxicity;Implant;improved;Inbred BALB C Mice;Infiltration;Inflammation;Infusion procedures;Injury;Injury to Kidney;innovation;Interstitial Nephritis;Intervention;ipilimumab;Kidney;kidney biopsy;kidney dysfunction;Kinetics;Ligands;Lymphocyte;Malignant Neoplasms;Masks;Measures;Mediating;Modeling;Monitor;mouse model;multidisciplinary;Mus;NCI-Designated Cancer Center;Nephrology;nephrotoxicity;Newborn Infant;Nivolumab;novel;novel marker;Pathology;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Phenotype;pre-clinical;pre-clinical assessment;Pre-Clinical Model;Preclinical Testing;preservation;prevent;programmed cell death protein 1;Proteomics;receptor;reconstitution;Regimen;renal damage;Renal function;Research;response;restoration;Risk;Serum;Signal Transduction;System;T-Lymphocyte;Therapeutic;Time;Toxic effect;Toxicology;translational impact;treatment response;tumor;urinary;Vasculitis

PROJECT_TITLE: Preclinical and Clinical Models of Drug Induced Kidney Injury

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Social connection is an essential human aspect, yet is poorly understood despite the developmental implications on well-being and development during adolescence, especially for the current GenZ population. This project will disentangle the different elements of social connection in adolescence and its associations to well-being using multiple measurements across short-term (daily) and long-term (across months) time, as well as neurobiological assessment, across contexts. This information will help inform “when” and “who” need intervention to promote positive well-being (and prevent negative well-being) outcomes in support of healthy adolescent development.

PI_NAMEs: HUDAC, CAITLIN MACKENZIE;XIA, MENGYA  (contact)

PROGRAM_OFFICER_NAME: GALLEN, COURTNEY LEIGH

PROJECT_TERMS: 17 year old;Accounting;Address;Adolescence;Adolescent;Adolescent Development;adolescent health;adolescent mental health;Adult;Age;Behavioral;Brain;design;Development;diaries;Distress;Electroencephalography;Elements;Enrollment;Ensure;experience;experimental study;Face;Family;Feeling;follow-up;Gender;Goals;Human;intersectionality;Intervention;Life;Liquid substance;Longitudinal Studies;Longterm Follow-up;Maps;Measurement;Measures;Mental Health;Modeling;multilevel analysis;Nature;neural;neurobiological mechanism;Neurobiology;Outcome;Participant;Pathologic;peer;Perception;Personal Satisfaction;Persons;physical conditioning;Population;predictive marker;prevent;Prevention;Probability;Process;prospective;psychologic;Puberty;Questionnaires;Race;Research Design;Risk Factors;Sampling;sex;social;Social Behavior;social exclusion;social factors;Social Interaction;Social isolation;social reciprocity;Specificity;Subgroup;Time;visual tracking;Work

PROJECT_TITLE: Reciprocity of Social Connection and Well-Being: Convergence of Temporal and Neural Underpinnings of Adolescent Social Connection Quality, Quantity, and Need

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(90)S]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Genetics;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Malaria remains one of the biggest infectious disease problems in the world, and a major reason for this is resistance of malaria parasites to available drugs. New antimalarial drugs are needed, and a number of candidates are under development. The goals of this project are to characterize ex vivo sensitivity to new antimalarial agents in Uganda and Burkina Faso and genotypic and phenotypic characterization of drug sensitivity outliers to inform optimal choices of new antimalarial drug combinations and the direction of continued drug discovery efforts

PI_NAMEs: ROSENTHAL, PHILIP JON (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Africa;African;antagonist;Anti-malarials;Area;Artemisinins;Burkina Faso;Coculture Techniques;Collaborations;Combined Modality Therapy;Communicable Diseases;Complex;Data;Development;drug action;Drug Combinations;drug discovery;Drug resistance;drug sensitivity;Drug Targeting;Falciparum Malaria;fitness;Funding;Genes;Genetic Polymorphism;genome sequencing;Genotype;Goals;Growth;improved;Individual;Infection;interest;Laboratories;Laboratory Study;Lead;Link;Malaria;malaria transmission;Mediator;Medicine;Molecular;Mutation;New Agents;next generation;novel;Parasites;Pattern;Pharmaceutical Preparations;Phenotype;Plasmodium falciparum;Predisposition;Property;Proteins;Resistance;resistance mechanism;Role;Seasons;Site;Southeastern Asia;synergism;Technology;Testing;Time;Toxic effect;transmission process;Treatment Efficacy;Uganda;whole genome

PROJECT_TITLE: Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI) are intersecting diseases affecting a significant portion of the global population. Spatial transcriptomics technology provides insights into cell type heterogeneity, but identifying colocalizing cell types and understanding fibrosis, immune interactions, and epithelial repair in kidney spatial transcriptomics data present computational challenges. In this project, we use AI-based spatial transcriptomics methods with multi-omics cell atlas data to understand the pathogenesis of kidney disease.

PI_NAMEs: EADON, MICHAEL THOMAS;MA, QIN ;WANG, JUEXIN  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Atlases;Brain;cell injury;cell type;Cells;Chronic Kidney Failure;Communities;Complex;Computing Methodologies;Data;deep learning;Disease;Distant;empowerment;epithelial repair;Fibrosis;Genomics;Goals;Graph;graph neural network;Health;Heart;Heterogeneity;Human;Human BioMolecular Atlas Program;Immune;Individual;Injury;Injury to Kidney;insight;Kidney;Kidney Diseases;Lung;Methods;Molecular Profiling;mosaic;Multiomic Data;multiple omics;Nephrons;Organ;Pathogenesis;Performance;Physicians;Population;precision medicine;prevent;Process;Public Health;Research;self supervised learning;Technology;Training;transcriptome;transcriptomics

PROJECT_TITLE: SCH: Graph-based Spatial Transcriptomics Computational Methods in Kidney Diseases


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: 8. Project Narrative This proposal seeks to improve the clinical utility of cardiac magnetic resonance imaging (CMR) for the evaluation of heart failure (HF) by creating simplified and robust free-breathing, non-ECG gated techniques which can simultaneously assess myocardial function using cine imaging and evaluate myocardial scar using T1 mapping and late gadolinium enhanced imaging in under 5 minutes. HF is highly prevalent affecting 6.2 million patients in the US. If a comprehensive CMR exam could be performed rapidly using a simplified protocol, the diagnostic and prognostic advantages of CMR for the assessment of HF could be extended to a broader range of patients potentially providing more accurate and specific diagnoses of the cause of a patients HF.

PI_NAMEs: SALERNO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Address;Affect;American;Assessment tool;Breathing;Cardiac;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiovascular system;Cessation of life;Cicatrix;Clinical;Clinical Research;Communities;Data;data space;Development;Diagnosis;Diagnostic;Dictionary;Dimensions;Echocardiography;Electrocardiogram;Etiology;Event;experience;extracellular;Fibrosis;Gadolinium;Grant;Guidelines;Heart;Heart failure;heart function;high risk;Hospitalization;Hour;Image;Image Analysis;Image Enhancement;Imaging Techniques;improved;Learning;Left Ventricular Ejection Fraction;Maps;Measurement;Modeling;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;multitask;Myocardial;Outcome;Patients;Physiologic pulse;Prevalence;prognostic;Protocols documentation;Public Health;Quality of life;Radial;Reader;real-time images;reconstruction;Recovery;Resolution;respiratory;Signal Transduction;Slice;Techniques;temporal measurement;Testing;Validation;Ventricular Function

PROJECT_TITLE: Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Spinal Muscular Atrophy is a devastating neuromuscular disease caused by insufficient amounts of SMN protein. The basic mechanism of how the reduction in SMN protein leads to the loss of motor neuron function is not known. Using genetic mutations in the SMN gene we can test the function of SMN in cells and mice to determine if splicing defects are the root cause of SMA.

PI_NAMEs: BURGHES, ARTHUR H. M. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Address;Affect;Alleles;Animals;autosome;Axon;Binding;Biochemical;Biochemical Pathway;Biological Assay;Birth;C-terminal;Cell Culture Techniques;Cell Line;Cell Survival;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Critical Pathways;Defect;Development;Disease;DNA Sequence Alteration;effective therapy;Electrophysiology (science);Engineering;Excision;Exons;Genes;Genetic;Genetic Suppression;Human;Length;loss of function;Missense Mutation;Modeling;Motor;motor neuron function;Motor Neurons;mouse model;Mus;mutant;Mutate;Mutation;Nervous System Disorder;Neuromuscular Diseases;overexpression;Pathogenesis;Pathway interactions;Patients;Phenotype;profilin;Proteins;Reporting;RNA;RNA Splicing;Role;Small Nuclear Ribonucleoproteins;SMN deficiency;SMN protein (spinal muscular atrophy);SMN1 gene;SMN2 gene;snRNP Biogenesis;Spinal Muscular Atrophy;Study models;survival motor neuron gene;System;Tertiary Protein Structure;Testing;Transgenic Mice;Translating;Translations;U7 Small Nuclear Ribonucleoprotein;Zebrafish

PROJECT_TITLE: Genetic Suppression of SMN Mutations in Spinal Muscular Atrophy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE  Congenital heart disease (CHD) is the most frequent birth defect in the United States, but only few genetic loci have been identified in some CHDs. Genomic sequencing efforts identified many genetic variants as potentially associated with CHD in a patient-specific fashion, but validation has not been trivial, in part due to a likely oligogenic basis for many CHDs, including the severe hypoplastic left heart syndrome. We propose a multi- system platform using Drosophila, with validation in human iPSC and zebrafish models to evaluate CHD gene candidates in health and potentially disease causing, and to build CHD-based gene regulatory networks.

PI_NAMEs: BODMER, ROLF  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Animals;Binding Sites;Bioinformatics;Candidate Disease Gene;candidate identification;Cardiac;cardiogenesis;causal variant;Cells;Clinic;cohort;combinatorial;Complex;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Data;Defect;Development;diagnostic development;diagnostic tool;Disease;Drosophila genus;Embryo;Embryonic Heart;fly;GATA4 gene;gene discovery;Gene Expression Profile;gene function;gene network;Gene Proteins;gene regulatory network;Genes;Genetic;genetic variant;genome sequencing;genomic locus;Genomics;Goals;Grant;Growth;Health;Heart;heart cell;heart function;Human;human disease;human induced pluripotent stem cells;Hypoplastic Left Heart Syndrome;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;insight;Mitochondria;Modeling;Molecular Genetics;multidisciplinary;mutant;Mutation;myocyte-specific enhancer-binding-factor 2C;Nature;Neonatal Mortality;novel;Orthologous Gene;Pathway interactions;Patients;Phenotype;Proliferating;prototype;Publications;Ribosomal Proteins;RNA Interference;Role;single-cell RNA sequencing;Sorting;Specific qualifier value;System;Testing;Therapeutic Intervention;Tin;transcription factor;United States;Validation;Variant;whole genome;Zebrafish

PROJECT_TITLE: Genetic Control of Cardiac Development: Congenital Heart Disease Gene Discovery in Drosophila

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ORG_CITY: LOS ANGELES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The goal of this project is to identify the cell-type diversity and gene regulatory programs in developing human brains. To this end, the project will generate single-cell datasets of DNA methylation, chromosomal architecture, chromatin accessibility and gene expression. The results generated from this project will aid in the understanding of neuropsychiatric disorders such as schizophrenia or autism that involve impaired brain development.

PI_NAMEs: LUO, CHONGYUAN  (contact);PAREDES, MERCEDES

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: 10 year old;3-Dimensional;5 year old;Adult;age group;Alleles;Architecture;Atlases;autism spectrum disorder;Automobile Driving;Biological Assay;Birth;Brain;brain cell;BRAIN initiative;Brain region;Catalogs;Cell Lineage;Cell model;Cell Nucleus;cell type;Cells;Childhood;Chromatin;Chromatin Loop;Classification;collaboratory;combinatorial;Complement;Computing Methodologies;Consensus;Data;Data Analyses;data management;data modalities;data resource;Data Set;Development;Developmental Gene;digital;Disease;DNA;DNA Methylation;DNA methylation profiling;Enhancers;Epigenetic Process;epigenomics;Event;Exhibits;experience;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene interaction;gene regulatory network;Generations;Genes;genetic variant;genomic data;Goals;Human;impaired brain development;In Situ;innovation;Joints;Life;Link;Location;Maps;Mental disorders;Methods;methylome;Modeling;Molecular;Molecular Conformation;Molecular Profiling;multimodality;Mus;nano-string;Neocortex;neuropsychiatric disorder;nonhuman primate;novel;Nucleic Acid Regulatory Sequences;Play;Population;postnatal period;predictive modeling;Predisposition;Pregnancy;prenatal;Process;programs;Property;Regulatory Element;Research Personnel;Resources;response;RNA;RNA methylation;Role;Sampling;Schizophrenia;Sensory;Series;single cell ATAC-seq;single cell technology;spatiotemporal;Specific qualifier value;stem cells;Symptoms;Time;Tissues;tool;transcription factor;transcriptome;transcriptomics;Transitional Cell;Variant

PROJECT_TITLE: Spatiotemporal epigenomic and chromosomal architectural cell atlas of developing human brains


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Health Services;Mental Health;Mental Illness;Serious Mental Illness

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE To-date, depression interventions in low- and middle-income countries have struggled on two fronts: they often fail to leverage the infrastructure of existing chronic care systems to reduce costs and improve quality, and they tend to overlook indirect benefits on broader health outcomes and other individuals. We will evaluate the effectiveness and cost-effectiveness of a stepped-care model of depression treatment integrated into Malawi’s national HIV platform, specifically examining depression symptoms, functional impairment, and overall health of 420 adults with moderate/severe depression. We will achieve this by conducting a stepped-wedge cluster randomized trial in which n=14 health facilities are randomized to implement depression care for patients (n=420) in five steps (2-3 facilities per step) over a 15-month period and measured at three months intervals inclusive of baseline, pre-treatment, post-treatment, 6- and 12-months follow-up—with cost-effectiveness taking into account indirect benefits on comorbid conditions such as HIV and hypertension, and household- level effects such as reduced burden of care.

PI_NAMEs: MCBAIN, RYAN K (contact);WAGNER, GLENN JOHN

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Accounting;Address;Adherence;Adult;Affect;Africa South of the Sahara;Aftercare;anti-depressive agents;Blood Pressure;burden of illness;care burden;care delivery;care systems;Caring;Chronic Care;Clinic;cluster randomized design;Cluster randomized trial;Collaborations;comorbidity;cost;Cost Analysis;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost estimate;Country;Dedications;depression model;depressive symptoms;design;Diabetes Mellitus;diagnostic tool;disability;Disease;economic impact;Effectiveness;effectiveness evaluation;effectiveness measure;Emotional;Epidemic;EuroQOL;Evaluation;evidence base;experience;Financial Support;follow-up;Functional impairment;Funding;Health;Health care facility;HIV;Household;human capital;Human Resources;Hypertension;improved;Incidence;Individual;infectious disease treatment;informant;Infrastructure;Institution;integrated care;International;Intervention;Interview;low and middle-income countries;Major Depressive Disorder;Malaria;Malawi;Maps;Measures;member;Mental Depression;Mental disorders;Mental Health;Mentorship;Methods;Modeling;Outcome;Output;Participant;participant enrollment;Patient Care;Patients;Perception;Phase;physical conditioning;post intervention;Prevalence;primary outcome;problem solving therapy;programs;Protocols documentation;Provider;Randomized;Research;response;scale up;screening;Screening procedure;secondary outcome;service delivery;Services;success;symposium;Time;tool;Training;treatment as usual;treatment effect;Uganda;Universities;Viral;Viral Load result;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: Integrating a Stepped Care Model of Screening and Treatment for Depression into Malawi's National HIV Care Delivery Platform


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Addictive drugs usurp the normal neural machinery for learning and memory to generate maladapted pathological cognitions for compulsive drug seeking. The neural circuits governing drug associative learning interface between the drug-evoked molecular cellular adaptations and drug-seeking behaviors. A mechanistic understanding of these neural circuits is of major significance for advancing our knowledge on drug-induced cognitive states and developing novel therapeutic treatments for substance use disorders.

PI_NAMEs: SUN, YANJUN  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Advanced Development;Affect;Animal Behavior;Animal Model;Association Learning;Behavioral;Brain;Brain region;cell type;Cells;Clinical;Code;Cognition;Cognitive;Color;Communication;Computer Models;conditioned place preference;conditioning;Data;Development;drug craving;drug relapse;drug reward;drug seeking behavior;Drug Targeting;Drug usage;drug withdrawal;Exposure to;Genetic;Goals;Head;high dimensionality;Hippocampal Formation;Hippocampus;human model;Image;Imaging Device;in vivo;in vivo imaging;Individual;insight;Intervention;Ketamine;Knowledge;Knowledge acquisition;Label;Learning;machine learning method;Maps;Mediating;Memory;Methods;Modeling;Molecular;Morphine;Mus;Nature;Negative Reinforcements;neural;neural circuit;neural model;neuroimaging;Neurons;novel;novel therapeutics;Opioid;opioid withdrawal;Output;Pathologic;Perception;Pharmaceutical Preparations;Positioning Attribute;programs;prolonged abstinence;Property;psychostimulant;Public Health;Research;response;Retrieval;Rewards;Running;skill acquisition;Speed;Substance Use Disorder;substance use treatment;Testing;Therapeutic;tool;Training;virus genetics;Withdrawal

PROJECT_TITLE: Neural circuit mechanisms of drug-context associations in the hippocampus

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This research project is focused on enabling the development of a new class of chemotherapeutic agents based on a protein that is found naturally in the human body. Specifically, the agents are based on ribonuclease, which is an enzyme that can enter human cells and catalyze the cleavage of RNA, leading to cell death. The goal of the project is to obtain fundamental insights into the relationship between the amino-acid sequence of ribonuclease, its three-dimensional structure, and its biological function, and to use those insights to create novel ribonucleases of potential therapeutic utility.

PI_NAMEs: RAINES, RONALD T (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Affinity;Amino Acid Sequence;anti-microbial drug;Asparagine;Bacterial RNA;Benign;Binding;Biochemical;Biochemistry;Biological Process;cancer cell;cathelicidin antimicrobial peptide;Cell Death;Cells;Cellular biology;chemotherapeutic agent;Clinic;Clinical;clinical research site;Clinical Trials;Complex;Cysteine;Cytosol;cytotoxic;cytotoxicity;Cytotoxin;Development;Endowment;Enzyme Precursors;Enzymes;Esterification;glycosylation;Goals;Grant;Homologous Gene;Human;Human body;In Vitro;in vivo;inhibitor;insight;intein;Link;Malignant Neoplasms;Mediating;Metalloproteases;Methods;Molecular Biology;Molecular Conformation;novel;oxidation;oxidative damage;Pancreas;Pancreatic ribonuclease;Pathway interactions;Peptide Hydrolases;Peptides;Pharmaceutical Preparations;Physiological;Physiology;Polysaccharides;Prodrugs;Protein Splicing;Proteins;public health relevance;Reaction;Reactive Oxygen Species;Research;Research Project Grants;Ribonucleases;RNA;Role;sensor;small molecule;Structure;Therapeutic;three dimensional structure;Toxic effect;Translating;uptake;Variant

PROJECT_TITLE: Human Ribonuclease as a Cytotoxin

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Immunology and microbiology are essential to understanding human health and disease, and therefore obtaining fundamental knowledge of pathogenic microbial agents and the immune response is of paramount importance. This proposal is a request for continued funding of an institutional combined pre- and postdoctoral NRSA Training Program in Immunology and Molecular Pathogenesis at Northwestern. Funded since 1996, this training program remains deeply committed to training the next generation of successful immunologists and microbiologists.

PI_NAMEs: THORP, EDWARD BENJAMIN (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TITLE: Immunology and Molecular Pathogenesis Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Autoimmune Disease;Celiac Disease;Digestive Diseases;Immunotherapy;Nutrition

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE This research proposal addresses the contribution of B lymphocytes, specialized cells mostly studied for their ability to differentiate into antibody-secreting cells, to the pathogenesis of celiac disease. The proposed studies will shed light on the ability of B lymphocytes to interact with T lymphocytes to promote inflammation and intestinal tissue damage and will test the relevance of B cell therapy as a therapeutic strategy for celiac disease.

PI_NAMEs: ABADIE, VALERIE  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Address;Adherence;Affect;Antibodies;Antibody Formation;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoantibodies;Autoimmune Diseases;Automobile Driving;B cell therapy;B-Cell Activation;B-Lymphocytes;Case Study;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Celiac Disease;cell mediated immune response;Cells;Cellular Immunity;Chronic;Clinical;Complex;cytokine;cytotoxic;Data;deamidation;Development;dietary;Disease;effective therapy;effector T cell;Enzymes;Epithelial Cells;Exposure to;Functional disorder;Gene Expression Profile;Genetic Transcription;Gluten;Gluten-free diet;HLA-DQ2;HLA-DQ8 antigen;Immune;Immune System Diseases;Immunoglobulin-Secreting Cells;Immunology;immunopathology;Impairment;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;innovation;insight;Intervention;intestinal epithelium;Intestinal Mucosa;Intestines;intraepithelial;Knowledge;Laboratories;Lamina Propria;Mediating;mesenteric lymph node;Modeling;Monitor;mouse model;Mucous Membrane;Mus;novel therapeutics;oral tolerance;Pathogenesis;Pathway interactions;Patients;Peptide antibodies;Peptides;persistent symptom;Peyer's Patches;Phenotype;Plasma Cells;Play;Population;Predisposition;prevent;Production;programs;Proliferating;Property;Research Proposals;response;Role;Severity of illness;Small intestine mucous membrane;Small Intestines;stem;Stress;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic target;therapeutically effective;Time;Tissues;tositumomab;transcriptome sequencing;Transgenic Mice;transglutaminase 2;uptake;Villous Atrophy

PROJECT_TITLE: B cell-T cell crosstalk in celiac disease

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: The proposed research is relevant to public health because the geriatric syndromes, such as heart failure and frailty, are a major reason why elders lose the ability to live independently, and result in large individual, family, and societal costs for medical, personal, and custodial care of dependent elders. The proposed project seeks new treatments for ameliorating the geriatric syndromes, and preserving elder independence, based on molecular mechanisms that regulate longevity and diseases of aging. The project will explore one such molecular mechanism, ketone bodies, in deep detail, and attempt to understand how ketone bodies affect specific geriatric syndromes and diseases of aging.

PI_NAMEs: STUBBS, BRIANNA JANE (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Affect;age related;age-related disease;Aging;aging biomarker;aging mechanism;aging related;aging related disease;Animals;Aorta;Award;beta-Hydroxybutyrate;Biological Markers;Biology;biomarker selection;Biopsy;Blood;Blood Vessels;Brain;Businesses;Caenorhabditis elegans;Cardiac;career;career development;Chronic;Clinical;Clinical Research;Clinical Trials;Complement;Complex;Custodial Care;Data;Development;Development Plans;dietary;dietary restriction;drug development;Drug Industry;EFRAC;Elderly;Elements;Endothelium;Entrepreneurship;Enzymes;Epigenetic Process;Esters;experience;extend lifespan;Family;Fasting;Fatty acid glycerol esters;Food;Frail Elderly;frailty;functional decline;Functional disorder;functional outcomes;Future;Geroscience;gerotherapeutic;Goals;Health;healthspan;Heart;Heart Diseases;Heart failure;Human;Immersion;Immune;Immune System Diseases;improved;Individual;Industry;Inflammation;Inflammatory;Ingestion;inhibitor;Intervention;Intravenous;ketogenic diet;Ketone Bodies;Ketones;Knowledge;Left Ventricular Ejection Fraction;life span;Lipids;Liver;Longevity;Mass Spectrum Analysis;Measures;Medical Care Costs;meetings;Mentors;Mentorship;Metabolic;Metabolism;Metformin;Methods;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Mus;Muscle;Myocardium;Obesity;older adult;Oral;Organ;Outcome Measure;Oxidative Stress;Pathway interactions;Patients;Physiological;Physiology;Plasma;pre-clinical;Pre-Clinical Model;preservation;Production;Program Development;Proteins;Proteomics;Public Health;randomized placebo controlled study;Rattus;Research;research and development;Research Institute;Research Personnel;Risk;Rodent;Rodent Model;Role;Scientist;Self Care;senescence;senescence associated secretory phenotype;Signal Transduction;Skeletal Muscle;skills;societal costs;Strenuous Exercise;stressor;Syndrome;Testing;Therapeutic Uses;Tissues;Translating;translational potential;Translational Research;translational scientist;translational therapeutics;United States National Institutes of Health;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Exogenous ketones target geroscience pathways and ameliorate geriatric syndromes


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: MISCELLANEOUS

ORG_NAME: PURDUE UNIVERSITY

PHR: Project Narrative  Neutrophils provide a critical defense against infection, but they can also promote tumor progression and metastasis in the aggressive glioblastoma. This study will employ a novel strategy to interrogate neutrophil biology and reprogram tumor-associated neutrophils into antitumor effector cells, which will have implications for developing novel neutrophil-targeted strategies for treating cancer, neutropenia and inflammation.

PI_NAMEs: BAO, XIAOPING  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: 3-Dimensional;Address;Animals;antitumor effect;Architecture;Bioinformatics;Biology;Biomimetics;Blood;Blood - brain barrier anatomy;Blood Vessels;cancer cell;cancer therapy;Cell Therapy;cell type;Cells;chemotherapy;Chemotherapy and/or radiation;chimeric antigen receptor;Clinical;Coculture Techniques;cytokine;cytotoxicity;Development;Disease;Effector Cell;engineered stem cells;Engineering;Evaluation;exosome;experience;Gelatinase B;Gene Expression;Gene Modified;Genes;Genetic Engineering;genome editing;Glioblastoma;Goals;Growth;Hematopoietic stem cells;Heterogeneity;Human;Human Engineering;human induced pluripotent stem cells;IL17 gene;Immune;Immunotherapy;improved;In Situ;in vivo;Infection;Infiltration;Inflammation;Inflammatory;innovation;insight;interstitial;Knowledge;Life;life span;Lung;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;Microfluidic Microchips;Microfluidics;Microglia;MicroRNAs;Modeling;Morphology;mouse model;Mus;Neoplasm Metastasis;neuro-oncology;Neutropenia;neutrophil;Neutrophil Infiltration;novel;novel strategies;Organoids;Pathologic;Patient Isolation;Patients;Phenotype;Play;pre-clinical;Primary carcinoma of the liver cells;programs;Proteins;Proteomics;Publishing;Radiation therapy;Resistance;Role;single-cell RNA sequencing;Slice;Solid;Solid Neoplasm;Specimen;targeted cancer therapy;temozolomide;Testing;therapeutic target;therapy resistant;Time;Tissues;tool;transcriptome sequencing;Transforming Growth Factor beta;transplant model;tumor;Tumor Antigens;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor stage;Vascularization;Xenograft procedure

PROJECT_TITLE: Engineer Biomimetic Microfluidic Models to Investigate and Reprogram Tumor Associated Neutrophils for Cancer Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Atherosclerosis;Building Research Capacity at Institutions with Limited NIH Funding;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: PROJECT NARRATIVE Human fibroatheroma cap rupture leads to myocardial infarction and sudden death in more than half a million Americans every year. We discovered that microcalcifications within the fibroatheroma can significantly increase the risk of fibroatheroma rupture. We here investigate whether microcalcifications in the cap is an sensitive and specific biomarker of fibroatheroma cap rupture.

PI_NAMEs: CARDOSO, LUIS  (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: 3-Dimensional;absorption;acute coronary syndrome;Agreement;American;aortic arch;Apolipoprotein E;Apoptosis;Area;Arterial Fatty Streak;Arteries;Biological;Biological Markers;Biomechanics;Breast Microcalcification;calcification;Cardiovascular system;Cessation of life;Clinical;Collagen;contrast enhanced;Coronary;coronary artery calcification;Coronary Vessels;density;Descending aorta;digital;Elements;Environment;experience;Frequencies;Geometry;high risk;Histologic;histological image;Human;human tissue;Hypertension;Image;in vivo;Infiltration;Inflammation;Intrinsic factor;Knockout Mice;Lesion;Lipids;Logistic Regressions;Macrophage;Maps;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;mechanical force;Mechanical Stress;Mechanics;meter;Modeling;Morphology;Mus;Myocardial Infarction;Necrosis;old mice;Pathologic;Patients;Play;prevent;Process;Property;Regression Analysis;Research;Resolution;Risk;Risk Factors;Risk Reduction;Roentgen Rays;Role;Rupture;Sampling;Scanning;Sensitivity and Specificity;Shapes;Site;Smooth Muscle Myocytes;soft tissue;Spatial Distribution;specific biomarkers;Stenosis;Stress;Sudden Death;Testing;Thick;Thinness;Thrombus;Tissue Inhibitor of Metalloproteinases;tissue stress;Tissues;vasa vasorum;Vascular calcification

PROJECT_TITLE: Microcalcifications in Atherosclerotic Plaque


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  A hallmark of HIV infection is intestinal inflammation, which results in irreversible depletion of gut resident CD4+ T cells and loss of intestinal epithelial integrity. This is then believed to cause translocation of gut bacteria into the circulation, chronic systemic immune activation and HIV disease progression. In this proposal we will utilize unique human cohorts in sub-Saharan Africa in combination with in vivo and ex vivo model systems and cutting-edge technologies to investigate the mechanism by which HIV infection results in defects in the gut epithelium and intestinal stem cells.

PI_NAMEs: KLOVERPRIS, HENRIK ;KWON, DOUGLAS  (contact);YILMAZ, OMER

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;Africa South of the Sahara;antiretroviral therapy;Apoptosis;Area;Bacteria;Biological Markers;Biological Models;Biopsy;Biopsy Specimen;Blood;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cessation of life;Chronic;Circulation;cohort;Colon;cytokine;Data;Defect;Development;Disease;Disease Progression;Duodenum;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;exhaustion;experience;Functional disorder;gastrointestinal;gastrointestinal epithelium;Gastrointestinal tract structure;Genetic Transcription;graft vs host disease;gut bacteria;gut dysbiosis;gut inflammation;Health;Heart Diseases;Histology;HIV;HIV Infections;Homeostasis;Hospitals;Human;Hyperglycemia;IL17 gene;Immune;immune activation;Immune System Diseases;Immunology;Impairment;improved;In Situ;in vivo;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;Intercellular Junctions;Interferon Type I;Interferon Type II;Interleukin-10;Interleukin-13;interleukin-22;intestinal barrier;intestinal epithelium;Intestinal Mucosa;Intestinal permeability;Intestines;Knowledge;Massachusetts;Mediating;MHC Class II Genes;microbial;microbial products;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mus;novel therapeutic intervention;Organoids;Outcome;Pathogenesis;Pathologist;Pathology;Pathway interactions;Peripheral;Permeability;Persons;Phenotype;Population;Positioning Attribute;Prevalence;Process;Production;Proliferating;protein expression;Regimen;Reporting;response;Role;Sampling;self-renewal;Signal Pathway;Signal Transduction;Site;South Africa;stem cell biology;stem cell differentiation;stem cell function;stem cell proliferation;stem cells;Stroke;System;systemic inflammatory response;T-Cell Depletion;T-Lymphocyte;Techniques;Technology;Testing;Tissue Sample;Tissues;Viral Load result;Virus Replication

PROJECT_TITLE: Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunction


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE - OVERALL COMPONENT The Colorado NORC will advance the science of nutrition and obesity by facilitating interdisciplinary, collaborative, translational research and by fostering the development of the next generation of scientists in the Rocky Mountain region. The Colorado NORC will accomplish this mission by support a research base of 118 funded scientists and their trainees with a pilot program, an enrichment program, and three biomedical research cores.

PI_NAMEs: MACLEAN, PAUL S. (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Area;base;Basic Science;Biomedical Research;career development;Clinical;Clinical Nutrition;Clinical Research;collaborative environment;Colorado;Community Outreach;community research;comorbidity;Development;Direct Costs;Discipline;Education;Effectiveness;Ensure;Environment;Equipment;Evaluation;Exercise;Exhibits;Faculty;Fostering;Funding;Growth;Health;health difference;improved;Institution;interdisciplinary collaboration;Interdisciplinary Study;Intervention;Investments;Knowledge;Leadership;Life;life span;Life Style Modification;Medical;member;Metabolic;Metabolism;Mission;Mississippi;next generation;novel;nutrition;Nutrition management;Nutritional Science;Nutritional Study;Obesity;obesity treatment;operation;Positioning Attribute;pre-clinical;pre-clinical research;preclinical study;Prevention;Productivity;programs;recruit;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Scientist;Secure;Sex Differences;skills;Strategic Planning;Structure;success;Technology;Training;Training Programs;Translating;Translational Research;translational scientist;translational study;Translations;United States;United States National Institutes of Health;Universities;Vision;Weight maintenance regimen;Wellness Center;Women's Health

PROJECT_TITLE: Colorado Nutrition Obesity Research Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PHR: The long-term goal is to understand how thermo-sensory stimuli are transformed into adaptive behaviors. By generating a model of these transformations spanning scales from cellular mechanisms to brain wide circuits we can uncover general principles of sensori-motor transformations. This will help understanding neural processing in health and disease states.

PI_NAMEs: HAESEMEYER, MARTIN  (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TERMS: Ablation;Adaptive Behaviors;Algorithms;Anatomy;Animals;Behavior;Behavioral;behavioral response;biophysical model;Biophysical Process;Biophysics;Brain;Brain Stem;Calcium;cell type;Cells;Data;Detection;Disease;Electrophysiology (science);Electroporation;Encapsulated;Environment;experimental study;Generations;Goals;Health;heat stimulus;Heating;hindbrain;Image;image guided;insight;Label;Maps;Modality;Modeling;motor control;Motor Neurons;Motor output;multi-scale modeling;Nervous System;Nervous System Disorder;neural;neural circuit;Neural Network Simulation;Neurons;Neurosciences;novel;Optics;Output;patch clamp;Physiologic Thermoregulation;Physiology;predictive modeling;Property;Research;Resolution;response;Role;Sensory;sensory input;sensory stimulus;Shapes;Stimulus;Study models;Techniques;Temperature;Testing;Time;Trigeminal System;two-photon;Vision;Work;Zebrafish

PROJECT_TITLE: Principles of sensorimotor processing in zebrafish thermosensation


NIH_SPENDING_CATS: Nutrition;Obesity

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Nutrition;Obesity;Physical Activity;Prevention

PI_NAMEs: CORNIER, MARC-ANDRE  (contact)

PROJECT_TERMS: Abbreviations;Address;Area;Award;base;Behavior Therapy;behavioral health;behavioral health intervention;behavioral outcome;Body Weight;Body Weight decreased;Center for Translational Science Activities;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Collection;Colorado;Communities;Consultations;cost;data access;design;Development;Diet;Dietary Intervention;doubly-labeled water;Eating Behavior;Electronics;energy balance;Equipment;Exercise;exercise intervention;exercise prescription;exercise training;experience;fitness;Fitness Centers;Fostering;Funding;Grant;Growth;Health;Hospitals;Individual;Information Storage;Information Systems;Information Technology;Infrastructure;interest;Intervention;Intervention Studies;Isotopes;Italy;Laboratories;lifestyle intervention;Maintenance;Mass Spectrum Analysis;Mediation;Medical;Modification;Molecular;Monitor;nutrition;Nutrition Assessment;Obesity;operation;Outcome Assessment;Participant;pediatric department;Pediatric Hospitals;Physical activity;Physiological;program costs;programs;Registries;Reporting;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Support;resistance exercise;response;Schools;Services;Supervision;System;Target Populations;Technology;Training Programs;Translational Research;Translations;Universities;Weight maintenance regimen;Well in self;Wellness Center;Work;Workplace

PROJECT_TITLE: Clinical Intervention and Translation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Aging is associated with cognitive decline, which can manifest pathologically as age-related dementia and is also the major risk factor for Alzheimer’s disease. There is currently no effective treatment for age-associated dementia and no therapies for Alzheimer’s disease. Our long-standing interest in the meninges and its role in brain function has led us to characterize meningeal lymphatic vessels and to observe many intriguing changes in meningeal immunity with age, and accordingly to raise the questions: are meningeal immune and lymphatic alterations relevant to age-related cognitive decline? If so, could meningeal lymphatic vessels or meningeal immune cells be therapeutically targeted to alleviate age-related dementia and/or Alzheimer’s disease? Here, we will elucidate the role of meningeal vasculature and immunity in age-associated cognitive decline, dementia and mouse models of Alzheimer’s disease using state-of-the-art imaging, surgical and pharmacological techniques in mice, as well as a validation of select findings in human dura specimens from fresh autopsies. Our findings may have significant potential to uncover the etiology of and novel therapeutic targets for age-related dementia and Alzheimer’s disease. ! !

PI_NAMEs: KIPNIS, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Ablation;Address;Affect;Age;age related;age related changes;Age-associated memory impairment;age-related disease;Aging;aging related;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer's disease therapy;Autopsy;Blood;Blood - brain barrier anatomy;Blood Vessels;Brain;Brain Diseases;Cell Compartmentation;Cells;Cognition Disorders;Cognitive;cognitive function;combat;cytokine;Data;Dementia;design;Development;Disease;Dura Mater;effective therapy;Etiology;Excision;Exhibits;Functional disorder;Funding;Homeostasis;Human;Image;Immune;Immune system;Immune Targeting;Immunity;Immunologic Surveillance;Impaired cognition;Impairment;improved;Inflammation;Inflammatory;interest;Interleukin-4;intravital imaging;learned behavior;Leukocyte Adhesion Molecules;Link;Lymphatic;lymphatic dysfunction;Lymphatic function;lymphatic vasculature;lymphatic vessel;Mediator;memory retrieval;Meningeal;Meningeal lymphatic system;Meninges;mouse model;Mus;Neonatal;Neurologic;Neurons;neuroregulation;new therapeutic target;old mice;Operative Surgical Procedures;Parabiosis;Pathologic;Peripheral;pharmacologic;Phenotype;Population;Prevalence;Publishing;Recombinants;Regulation;Regulatory T-Lymphocyte;Rejuvenation;Risk Factors;Role;Sampling;single-cell RNA sequencing;Specimen;Structure;Support System;System;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;thymus transplantation;Tight Junctions;Tissues;Validation;Vascular Diseases;VEGFC gene;Waste Products;web site

PROJECT_TITLE: Immune system supports brain function

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_CITY: Aurora

PI_NAMEs: KOHRT, WENDY M (contact)

PROJECT_TERMS: Abbreviations;Award;base;Body Composition;Body Water;Bone Density;Calibration;Center for Translational Science Activities;Centers of Research Excellence;Clinical;clinical center;Clinical Nutrition;Clinical Research;Colorado;comparative;Consultations;cost effectiveness;Data Analyses;data quality;doubly-labeled water;Dual-Energy X-Ray Absorptiometry;Education;Elderly;energy balance;Energy Intake;Energy Metabolism;Experimental Designs;Fatty acid glycerol esters;Food;Health;Health Expenditures;Hospitals;Human Resources;Individual;Inpatients;Institution;instrument;instrumentation;Isotopes;Laboratories;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Mass Spectrum Analysis;Measurement;Measures;Medicine;Mission;Musculoskeletal;National Institute of Diabetes and Digestive and Kidney Diseases;Needs Assessment;nutrition;Nutritional Study;Obesity;Outpatients;Output;oxidation;Participant;Pediatric Hospitals;Peripheral;Physical activity;Principal Investigator;Procedures;programs;Protocols documentation;quality assurance;Quality Control;Research;Research Personnel;Resolution;Resources;respiratory;Rest;Safety;Schedule;Science;Services;Sex Differences;Sleep;Specialized Center;Spectrum Analysis;stable isotope;Standardization;Techniques;Time;Tissues;tomography;total energy expenditure;Training;Translational Research;United States National Institutes of Health;Universities;Wellness Center;X-Ray Computed Tomography

PROJECT_TITLE: Energy Balance Assessment Core


PI_NAMEs: BERGMAN, BRYAN C (contact)

PROJECT_TERMS: analytical tool;Animals;Award;base;Basic Science;Bioinformatics;Biological Assay;Biological Metamorphosis;Blood;bone;Calibration;Cell Nucleus;Cells;Clinical Research;clinical translation;Colorado;Communities;Consultations;cost;Data;Data Analyses;Disease;Energy Metabolism;Enzyme-Linked Immunosorbent Assay;Equipment;Evolution;experience;Experimental Designs;experimental study;Fatty acid glycerol esters;Genus Hippocampus;Grant;high throughput analysis;Human;Human Milk;Human Resources;Hybrids;Individual;instrumentation;Interdisciplinary Study;Investigation;Isotopes;Kinetics;Laboratories;lipidomics;Liquid substance;Liver;Maintenance;Mass Spectrum Analysis;Measures;meetings;member;Metabolic;Metabolic Diseases;Metabolism;Mission;Mitochondria;Modernization;Molecular;mouse model;Muscle;Non-Insulin-Dependent Diabetes Mellitus;Nucleic Acids;nutrition;Nutritional Study;Obesity;Outcome;Pathology;Pathway interactions;PIK3CG gene;Plasma;Procedures;quality assurance;Quality Control;Regulation;Research;Research Personnel;Respiration;Reverse Transcriptase Polymerase Chain Reaction;Schedule;Services;Standardization;System;Techniques;Technology;Time;Tissues;tool;Tracer;Training;transcriptome sequencing;Translational Research;Western Blotting

PROJECT_TITLE: Molecular and Cellular Analytical Core


ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

PHR: Project Narrative The proposed research is relevant to public health because it addresses the molecular origins of chromosome instability, which is prevalent in cancer and reproductive aging. We will test the hypothesis that each person’s unique complement of centromeres contains molecular and genetic information that biases how accurately chromosomes are transmitted from cell to cell. The project is relevant to the NCI mission to discover molecular and genetic origins of human genome stability.

PI_NAMEs: GERTON, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: 3-Dimensional;Address;Affect;Amaze;Anaphase;Aneuploidy;Binding;Biology;blind;Calibration;Cancer Etiology;cancer type;Catenated DNA;Cell Culture Techniques;Cells;Centromere;ChIP-seq;Chromosomal Instability;Chromosome 4;chromosome loss;chromosome missegregation;Chromosome Segregation;Chromosome Structures;Chromosomes;cohesin;cohesion;Complement;Complex;Cultured Cells;Data;DNA;Double Strand Break Repair;Elements;Ensure;Environment;Event;Fatigue;Genetic;Genetic Determinism;genetic information;Genome;genome integrity;Genome Stability;Genomic Instability;genomic tools;Goals;grasp;Hand;Haplotypes;Health;Human;Human Cell Line;Human Chromosomes;Human Genome;Human Pathology;human tissue;Image;Imaging Device;Individual;innovation;Kinetochores;Literature;loss of function;Malignant Neoplasms;Maps;Mediating;Metaphase;micronucleus;Microtubules;Mission;Mitosis;Modeling;Molecular;molecular modeling;Mutation;Organizational Models;Outcome;Pathologic;Pattern;Persons;prevent;Proteins;Public Health;Repetitive Sequence;Reporting;reproductive senescence;Research;Role;segregation;Shapes;Sister Chromatid;superresolution imaging;Testing;Time;tissue/cell culture;tool;Topoisomerase II;transmission process;Tumor Tissue;tumor xenograft;Variant;Work;Yin-Yang

PROJECT_TITLE: Maintaining the integrity of a genome

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Clinical Research;Nutrition;Obesity

PI_NAMEs: BESSESEN, DANIEL HOLLAND (contact)

PROJECT_TERMS: Area;Award;base;Basic Science;career;Clinical Research;Colorado;Data;design;disability;disadvantaged background;Disease;Financial Support;Foundations;Funding;Individual;K-Series Research Career Programs;life span;medical schools;Minority Groups;nutrition;Nutritional Study;Obesity;Pilot Projects;Population Study;programs;Research;Research Personnel;Research Support;Secure;Source;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Pilot And Feasibility Program


PI_NAMEs: MELANSON, EDWARD L (contact)

PROJECT_TERMS: Ambulatory Monitoring;Award;base;career;Colorado;Communication;Communities;Community Outreach;Development;doctoral student;Education;Education and Outreach;Educational Activities;Educational workshop;Environment;Event;evidence base;Fostering;Funding;Goals;Health;Institution;interdisciplinary collaboration;interest;International;Investments;Journals;Knowledge;Link;meetings;Metabolic Diseases;Methodology;Mission;Movement;next generation;nutrition;Nutritional Science;Nutritional Study;Obesity;outreach;outreach program;Physical activity;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Personnel;Research Proposals;Resources;Science;Scientist;Secure;senior faculty;success;symposium;synergism;Training;Training and Education;training opportunity;Training Programs;Translating;United States National Institutes of Health;Wellness Center;working group

PROJECT_TITLE: Enrichment Program


ORG_CITY: KUMASI

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH

PHR: Narrative Thanks to effective treatment, people with HIV (PWH) are living longer and are now exposed to diseases that come along with aging. In sub-Saharan Africa, where most PWH live, less is known about the complex, multiple, interacting diseases that older PWH experience. Our study will describe these diseases of aging in PWH in Ghana, evaluate how they are currently being managed, and build a foundation on which to test a new model of care to treat older PWH to improve both the quantity and quality of live for this group.

PI_NAMEs: AYISI-BOATENG, NANA KWAME ;SO-ARMAH, KAKU ;TAWIAH, PHYLLIS  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;African;aged;Aging;aging and technology;aging related disease;antiretroviral therapy;Boston;Cardiometabolic Disease;care systems;Caring;Categories;Cessation of life;Chronic Disease;Clinical;clinical practice;Communicable Diseases;community organizations;Complex;Comprehensive Health Care;Country;Data;Dependence;diabetes management;Diagnosis;Disease;Disease Management;Dyslipidemias;effective therapy;effectiveness testing;Elderly;Enrollment;Epidemic;Epidemiology;experience;Exposure to;Family Practice;Female;follow-up;Foundations;frailty;Frequencies;Future;Geriatric Assessment;Geriatrics;Ghana;Goals;Guidelines;Health Personnel;Health Services;Healthcare;healthy aging;high risk;HIV;HIV therapy;human old age (65+);Hypertension;Impaired cognition;improved;Incidence;indexing;Informed Consent;Intervention Studies;Interview;kidney dysfunction;Life;Life Expectancy;Longitudinal, observational study;Measures;Medical Records;Mental Depression;Mental Health;Modeling;Morbidity - disease rate;mortality;mortality risk;multiple chronic conditions;older adult;Older Population;Organ;Outcome;Outcome Study;Participant;patient oriented;Patient Self-Report;Patients;peer;Perception;Persons;Phenotype;Physical assessment;physical conditioning;Physiological;Policies;policy implication;Polypharmacy;pragmatic trial;preservation;Prevalence;Principal Investigator;programs;Psychosocial Assessment and Care;Quality of life;Research;Research Assistant;Research Training;satisfaction;Science;screening;Screening Result;sex;social vulnerability;Structure;Surveys;Syndrome;Technology;Testing;Universities;University Hospitals;Update;Work

PROJECT_TITLE: KNUST Aging and HIV Outcomes

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases

PHR: Public Health Narrative: SARS-CoV-2 is a coronavirus and causative agent of COVID-19 that has caused a global pandemic pushing healthcare systems to their limits. To date, there is little understanding how coronaviruses such as SARS-CoV-2 utilize the host lipid network to spread from cell to cell. This project brings together a diverse set of researchers to understand assembly, budding and spread of SARS-CoV-2 from human cells, which should in turn identify novel drug targets in the viral life cycle.

PI_NAMEs: STAHELIN, ROBERT VIRGIL (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Address;Automobile Driving;Behavior;Binding;Biochemical;Biochemistry;Biological Models;biophysical analysis;Biophysical Process;Biophysics;biosafety level 3 facility;C-terminal;Category C pathogen;Cell membrane;Cells;Cellular Assay;Classification;Collaborations;Computer Analysis;Computer Models;computer studies;Coronavirus;COVID-19;Dangerousness;Data;Drug Targeting;experimental study;Fatality rate;Future;Genome;Goals;Golgi Apparatus;Grain;Grant;Healthcare Systems;Human;in silico;In Vitro;Infection;inhibitor;innovation;insight;International;Laboratories;Life Cycle Stages;Lipid Binding;Lipids;Measurement;Mediating;Membrane;Middle East Respiratory Syndrome;Modeling;Molecular;Molecular Conformation;molecular dynamics;Morbidity - disease rate;mortality;multiple myeloma M Protein;multitask;new therapeutic target;novel coronavirus;Nucleocapsid;Nucleoproteins;pandemic disease;particle;pathogen;Pathogenesis;Patients;Phosphatidylinositols;PIK3CG gene;Planet Earth;Play;Process;Production;programs;Property;Protein Analysis;Protein C;protein function;protein protein interaction;protein structure;Proteins;Public Health;public health emergency;recruit;Research;Research Personnel;RNA;Role;Severe Acute Respiratory Syndrome;Site;Sphingolipids;structural biology;Structural Models;Structural Protein;Structure;System;Techniques;Testing;Therapeutic;therapeutic development;therapeutic target;tool;United States National Institutes of Health;Vaccines;Validation;Viral;viral envelope lipids;Viral Genome;Viral Packaging;Viral Pathogenesis;Viral Proteins;Virion;virology;Virus;Virus Assembly;Virus Replication;Virus Shedding;World Health Organization;Zoonoses

PROJECT_TITLE: Elucidation of Assembly and Budding Mechanisms of SARS-CoV-2

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative The mission of this new NCI Youth Enjoy Science Training in Health Equity, Highlighting Environmental Inequities, & Growing neighborHood Teachers and Students (YES in THE HEIGHTS) program at the Herbert Irving Comprehensive Cancer Center (HICCC) is to reduce the cancer burden and cancer health inequities in the HICCC Catchment Area (CA) through training and mentoring of students and teachers to increase the diversity of future cancer researchers. We will continue our commitment to mentoring students in minority-serving institutions, including students from nearby City University of New York (CUNY), the largest minority-serving undergraduate university in the U.S. and have partnered with Math and Science for America (MfA) Program to develop novel training programs for high school students. Across all five years, YES in THE HEIGHTS will mentor, train and engage over 1,125 individuals within the communities we serve.

PI_NAMEs: MCDONALD, JASMINE ALISE (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: academic standard;Address;Affect;anti-cancer research;Area;Award;Basic Science;Biomedical Research;Cancer Burden;Cancer Etiology;cancer health disparity;Cancer health equity;cancer prevention;cancer risk;career;Catchment Area;Chemicals;Cities;citizen science;Clinical Research;cohort;college;Communities;Community Services;curriculum development;design;Development;Education Projects;Educational Curriculum;Educational process of instructing;Environment;environmental disparity;Environmental Epidemiology;Environmental Exposure;environmental justice;Etiology;experience;Faculty;Family;Future;Goals;Health;Health education;health equity;health inequalities;Height;Herbert Irving Comprehensive Cancer Center;high school;High School Student;Household;Individual;Inequity;Intervention;laboratory experience;Laboratory Research;Life Cycle Stages;Life Style;Malignant Neoplasms;Mathematics;member;Mentors;Mentorship;Middle School Student;Minority;Minority-Serving Institution;Mission;Modification;Molecular Epidemiology;Neighborhoods;New York;novel;outcome disparities;outreach;Poverty;Predisposition;Program Evaluation;programs;Public Health Schools;Research;Research Methodology;Research Personnel;Risk Factors;Risk Reduction;Running;Schools;Science;science teacher;screening;Smoking;social health determinants;student mentoring;Students;success;teacher;Toxicology;Training;Training Programs;undergraduate student;Underrepresented Minority;Underrepresented Students;Universities;virtual;Washington;Woman;Work;workforce needs;Youth

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Serious Mental Illness;Telehealth

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The proposed project seeks to reduce the burden of adolescent depression by evaluating in a randomized trial an 8-week mobile health meditation intervention in adolescents reporting elevated depressive symptoms and characterizing psychological, behavioral, and psychophysiological mechanisms of change using innovative ambulatory assessment methods. Long-term, this program of research is designed to test and optimize the feasibility, acceptability, safety, efficacy, and effectiveness of mobile technologies for the treatment and prevention of adolescent depression. The current study will provide essential training and pilot data for a future large-scale randomized clinical trial involving an active control arm and ambulatory assessment of candidate mechanisms of change.

PI_NAMEs: HIRSHBERG, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 3-Dimensional;acceptability and feasibility;active control;Address;Adolescence;Adolescent;Adult;arm;Attention;Award;Behavior;Behavior assessment;Behavioral;Caring;Cellular Phone;child depression;Clinical;Clinical Research;Clinical Trials;Cognitive;Complex;Control Groups;cost;Coupled;COVID-19 pandemic;Data;depressive symptoms;design;Development;effective therapy;Effectiveness;efficacy evaluation;Equation;follow-up;frontier;Funding;Future;Geography;Goals;Grant;Growth;Healthcare;Heart;Heart Rate;high school;Individual Differences;Information Systems;innovation;Intercept;Intervention;intervention delivery;Intervention Studies;K-Series Research Career Programs;Knowledge;Lead;Loneliness;Major Depressive Disorder;Mediating;Mediation;Mediator;Meditation;Mental Depression;Mental Health;Mental Health Services;Mentors;Methods;mHealth;mhealth interventions;Mind;mindfulness;mobile computing;Modeling;Outcome Measure;Participant;Patient Outcomes Assessments;Patient Self-Report;Personal Satisfaction;Persons;Pilot Projects;Population;Positioning Attribute;Prevalence;Prevention;programs;psychologic;Psychopathology;Psychophysiology;Race;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Religion;Reporting;Research;Rest;Safety;Sampling;service providers;skills;skills training;Sleep;sleep quality;smartphone application;social;Social isolation;Symptoms;Technology;Testing;Thinking;Training;Translational Research;Treatment Efficacy;United States;United States National Institutes of Health;virtual;Waiting Lists;wearable device;Work

PROJECT_TITLE: Smartphone-based meditation training to reduce adolescent depression

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Natural killer (NK) cell immunotherapies have been successfully developed for hematologic malignancies; however, their application to solid tumor malignancies faces several challenges. Using a customizable NK cell platform, we propose to design tumor-specific, off-the-shelf NK cell products as novel immunotherapies to treat brain tumors and prostate cancer. Jeffrey Miller, MD, is uniquely qualified to lead the proposed research, both because he has a successful track record of developing novel NK cell immunotherapies for hematologic malignancies and because he has assembled of team of established and new collaborators in NK cell biology and solid tumor malignancies.

PI_NAMEs: MILLER, JEFFREY S. (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Adoptive Transfer;Advanced Malignant Neoplasm;Allogenic;Area;Award;Biology;Blood Cells;Blood donor;Brain Neoplasms;cancer care;CD276 gene;Cell Lineage;Cells;Cellular biology;Cellular immunotherapy;chimeric antigen receptor;Clinical;Clinical Trials;Communities;cost;Cytomegalovirus;Dependence;design;Development;directed differentiation;Engineering;Environment;experience;Exposure to;Face;Funding;Genes;Glioblastoma;Goals;Grant;Hematologic Neoplasms;Homing;Hypoxia;Immune;Immunotherapy;Individual;induced pluripotent stem cell;Ink;interest;Interleukin-15;Investigation;Malignant neoplasm of prostate;Malignant Neoplasms;Methods;migration;Minnesota;nanobodies;Natural Killer Cell Immunotherapy;Natural Killer Cells;Normal tissue morphology;novel;novel strategies;Oncogenic;Output;overexpression;Patients;Population;programs;Proteins;Qualifying;receptor;Research;Solid Neoplasm;Specificity;stem cell genes;T-Lymphocyte;Testing;Translating;translational scientist;tumor;Universities;Work

PROJECT_TITLE: Targeting off-the-shelf iPSC-derived natural killer cells against solid tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_NAME: CHILDREN'S HOSPITALS AND CLINICS

PHR: NARRATIVE Relapse is a common problem in B-ALL. In response to PAR-20-292, we will decouple autonomous cell survival at a critical stage of B-cell developmental with an immunoconjugate against the pre-B-cell receptor. Limited in scope to B-ALL stages of developmental arrest, the immunoconjugate (alternatively, antibody-drug conjugate) will exploit normal internalization and transport mechanisms to effect cell killing, but without pan B-cell ablation or imbalanced T-cell activation. The problems we are trying to solve are relapse, opportunistic infections, and off-target toxicities in children and adults with B-ALL.

PI_NAMEs: GORDON, PETER M;WINTER, STUART SHELDON (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Ablation;acute lymphoblastic leukemia cell;Acute Lymphocytic Leukemia;adaptive immunity;Address;Adolescent;Adult;Adverse drug effect;Adverse event;Age;Algorithms;Antibodies;Antibody-drug conjugates;Antigen Targeting;Antigens;B cell repertoire;B cell therapy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Lymphomas;B-Lymphocytes;Biological Products;Blood;burden of illness;Cancer Patient;cancer therapy;cell bank;cell killing;Cell surface;Cell Surface Receptors;Cell Survival;Cell Therapy;Cells;Central Nervous System;chemotherapy;Child;Clinical;Clonal Expansion;Communicable Diseases;Data;Development;Diagnosis;Disease;disorder risk;Dose;Down-Regulation;Ethnic Origin;Event;Face;Family;Future;Genetic;Goals;Hepatic;Hepatocyte;high risk;humanized mouse;Immune;Immune system;Immunoconjugates;immunoreactivity;Immunotherapy;improved;In Vitro;in vivo;Infant;Infection;innovation;insight;Investigational Therapies;leukemia;leukemia relapse;leukemia/lymphoma;Leukemic Cell;Life;Liver;liver injury;Malignant Neoplasms;Mature B-Lymphocyte;Measurable;Mediating;Microvascular Dysfunction;Molecular;mortality risk;mouse model;Mus;Natural Immunity;novel;novel therapeutics;Opportunistic Infections;Organ;Pathway interactions;patient safety;patient subsets;Patients;Pediatric Oncology Group;Persons;Pharmaceutical Preparations;Pharmacologic Substance;phase 1 study;Phosphotransferases;Physiology;Population;Positioning Attribute;pre-B cell receptor;Precision therapeutics;preclinical study;Precursor B-Lymphoblast;Publishing;Race;receptor;receptor expression;Relapse;relapse risk;Residual Neoplasm;Resistance;resistance mechanism;response;Risk;Risk Reduction;Safety;Sampling;Science;Sepsis;septic;side effect;Signal Transduction;Surface;SYK gene;symptom management;T-Cell Activation;targeted treatment;Therapeutic Agents;therapy resistant;Toxic effect;Toxin;Treatment-related toxicity;young adult

PROJECT_TITLE: A Novel VpreB1 Anti-body Drug Conjugate for the Treatment of B-Lineage Acute Lymphoblastic Leukemia/Lymphoma


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Complementary and Integrative Health;Digestive Diseases;Genetics;Human Genome;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

PHR: PROJECT NARRATIVE The proposed research will lead to a better understanding of how host genetics and intestinal bacterial communities interact with each other to modulate inflammation in the developing neonatal gut. New knowledge gained from this research will also contribute to the development of personalized, microbial-based therapies based on underlying genetic predisposition and/or gut microbiome signatures to help maintain gut homeostasis. Such novel, individualized therapies are expected to drastically reduce the incidence of necrotizing enterocolitis in a safe and effective manner by targeting infants at highest risk of the disease.

PI_NAMEs: CUNA, ALAIN  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Antibiotics;Apoptosis;Award;bacterial community;Bioinformatics;Biology;career;Cellular biology;Child;Cities;Complex;CRISPR/Cas technology;Data;Development;disorder risk;driving force;dysbiosis;Environment;Etiology;Exhibits;experience;Family;fecal transplantation;Fostering;Funding;gene environment interaction;Genes;Genetic;Genetic Models;Genetic Predisposition to Disease;Genetic study;Goals;gut homeostasis;gut inflammation;gut microbiome;gut microbiota;high risk;Homeostasis;Human;Hyperactivity;Immune;Immunoglobulins;Immunologic Receptors;improved outcome;Incidence;individualized medicine;Infant;Inflammation;Inflammatory Bowel Diseases;Injury;insight;Interleukin-1;Intestines;Kansas;Knock-in Mouse;Knowledge;Laboratories;Measures;Medicine;Mentors;Mentorship;microbial;microbial based therapy;microbiome alteration;microbiome research;microbiome sequencing;microbiome signature;microbiome therapeutics;microbiota profiles;Molecular Biology;mouse model;Mus;Mutation;Nature;Necrotizing Enterocolitis;Neonatal;novel;Outcome;Pathogenesis;Pathologic;Pediatrics;Phenotype;Physicians;Positioning Attribute;Pre-Clinical Model;Predisposition;Premature Infant;Prevention;Probiotics;professor;programs;receptor;Receptor Activation;Receptor Signaling;Research;Research Ethics;Research Personnel;reverse genetics;Role;Scientist;skills;success;Testing;therapeutic evaluation;Time;Toll-like receptors;Training;Transgenic Mice;translational impact;United States National Institutes of Health

PROJECT_TITLE: Gene-environment interactions in necrotizing enterocolitis: impact of SIGIRR mutation and gut microbiota on intestinal TLR hyperactivity

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]