NIH_SPENDING_CATS: Bioengineering;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: Project Narrative We propose to study the molecular basis of how the ribosome translates the genetic information encoded in messenger RNAs into proteins. The main impacts of our work on public health are that: (i) Bacterial ribosomes are prime targets for many classes of clinically important antibiotics. These include the anti- tuberculosis antibiotic viomycin, whose mechanism of action we have recently elucidated. (ii) Many human RNA viruses, including HIV and coronaviruses, depend on programmed shifting of the translational reading frame for their pathogenicity. Our research has recently shed light on how the reading frame is maintained.

PI_NAMEs: NOLLER, HARRY F (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Antibiotics;Antitubercular Agents;Antitubercular Antibiotics;Biochemistry;Clinical;Collaborations;Complex;Computing Methodologies;Coronavirus;Coupled;Cryoelectron Microscopy;Development;Elongation Factor;exhaust;Fluorescence Resonance Energy Transfer;Genetic;genetic information;Head;helicase;HIV;Human;insight;Label;Laboratories;laser tweezer;Measurement;Messenger RNA;Methods;model design;Molecular;Molecular Conformation;Movement;Mutation;novel;novel strategies;optic tweezer;Pathogenicity;Peptide Elongation Factor G;preservation;Protein Biosynthesis;Proteins;Public Health;Reading Frames;Research;Ribosomal RNA;Ribosomes;RNA Viruses;Rotation;single molecule;single-molecule FRET;Site;structural biology;Structure;Transfer RNA;Translating;Viomycin;Work

PROJECT_TITLE: Ribosome Structure and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RAND CORPORATION

PHR: Project Narrative We seek to understand whether and how historical and current mortgage discrimination impacts obesity disparities through changes in neighborhood and resident behaviors. We propose to use a large longitudinal cohort of white and Black adults residing in four cities with mortgage discrimination histories to understand the paths by which mortgage discrimination may influence racial disparities in body mass index changes through dynamic neighborhood conditions, discrimination, homeownership, physical activity, and dietary behaviors. The results will deliver the needed evidence to guide housing and neighborhood policy by understanding whether and how long-term effects of historical mortgage discrimination and current biased mortgage lending underlie neighborhood and obesity disparities.

PI_NAMEs: RICHARDSON, ANDREA  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;Adult;aged;Area;Attention;Behavior;Black race;Body mass index;Censuses;Chicago;Cities;Coronary Artery Risk Development in Young Adults Study;Data;Database Management Systems;Diet;dietary;Discrimination;Disparity;Economic Conditions;Economics;Environment;Epidemic;Equation;Evaluation;Exposure to;follow-up;Food;Future;Geographic Information Systems;Geographic Locations;Health;Health behavior;health determinants;high risk;Home;Housing;indexing;Inequality;Investments;Knowledge;Link;Location;Long-Term Effects;Longitudinal cohort;Maps;Modeling;Neighborhoods;Obesity;obesogenic;Outcome;Ownership;Participant;Pattern;Persons;Physical activity;physical inactivity;Policies;Poverty;Price;Process;Race;racial bias;racial difference;racial disparity;Recording of previous events;Research;residence;Resources;Role;segregation;social;Social Conditions;sociodemographics;structural determinants;Time;United States;Variant

PROJECT_TITLE: Impacts of Discriminatory Mortgage Lending Practices on Obesity

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: PHILADELPHIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: 8. Project Narrative Adolescence is an “age of risk” for the emergence of major depressive disorder (MD), a major public health problem. Using an innovative biobehavioral high-risk approach with a prospective longitudinal design, this application will examine bidirectional relationships between peripheral inflammation and multimodal reward function and their joint prediction of first onset of MD and increases in depression symptoms, particularly anhedonia. It will provide critical tools for identifying vulnerabilities to MD, integrate two separate research traditions to increase our understanding of specific etiological pathways underlying MD, and facilitate development of behavioral and biological interventions for ameliorating reward processing and inflammatory abnormalities that contribute to MD.

PI_NAMEs: ALLOY, LAUREN BERSH (contact);NUSSLOCK, ROBIN

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: 15 year old;Adolescence;Adolescent;Age;Anhedonia;Attenuated;Behavior;behavior measurement;Behavior Therapy;Behavioral;biobehavior;Biological;Birth History;Blood;Brain;child depression;Childhood;Chronic;Code;Corpus striatum structure;cytokine;depressive symptoms;design;Development;Diagnostic;Diet;Dimensions;dysphoria;Etiology;Event;Excision;Failure;Fatty acid glycerol esters;Feedback;follow-up;Foundations;functional MRI scan;Generations;high risk;Immune;Immune signaling;Immune system;indexing;Inflammation;Inflammation Mediators;Inflammatory;innovation;Intervention;Interview;Joints;Life;Literature;longitudinal design;Longitudinal Studies;Major Depressive Disorder;Measures;Mediating;Mediator;Mental Depression;Modeling;multimodality;network models;neural;Neuroimmune;ninth grade;novel;Onset of illness;Participant;pathogen;Pathway interactions;Patient Self-Report;Peripheral;persistent symptom;predicting response;Prevalence;prevent;prospective;Public Health;Recording of previous events;Research;Resources;reward processing;Rewards;Risk;Risk Marker;Sampling;Signal Transduction;Sleep disturbances;social;Specific qualifier value;Stress;stressor;substance use;sugar;Symptoms;synergism;System;Tail;Testing;Time;tool;Unhealthy Diet;Work;wound healing

PROJECT_TITLE: Integrated Reward-Inflammation Model of First Onset of Major Depression in Adolescence

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Diabetes;Health Services;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The overall goal of this new program is to provide understanding of the risk factors for progression of childhood prediabetes to type 2 diabetes during puberty via a standardized, approach to characterize risk and disease mechanisms Children's Hospital of Philadelphia, a national leader in Diabetes research proposes to be a Clinical Center in the cooperative network of centers committed to research in the risks of T2DM.

PI_NAMEs: KATZ, LORRAINE E LEVITT (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Acceleration;actigraphy;adipokines;Adipose tissue;Adolescence;Adolescent;Adult;Algorithms;anxiety symptoms;Arginine;base;Beta Cell;biobank;Biological Markers;blood glucose regulation;Body Composition;Caring;Child;Childhood;Childhood diabetes;Clinical;clinical center;Collaborations;Communication;Communities;community based participatory research;Community Health Aides;Community Healthcare;Data;Data Collection;Defect;depressive symptoms;design;Deterioration;Development;Diabetes Mellitus;diabetes risk;Diet;digital health;Disease;DNA;Eating Behavior;Eating Disorders;Education;Environment;Evaluation;Exposure to;Family;Family history of;Fatty acid glycerol esters;Fetal Growth Retardation;Fetal Macrosomia;Future;Genetic Risk;genetic variant;Genomics;Genotype;Glucagon;Glucose;Goals;Growth;Health Personnel;healthy weight;Hepatic;high risk;Home Care Services;Home environment;Hormonal;Hour;Human;in utero;indexing;innovation;insight;Institution;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Interruption;Intervention;intrauterine environment;Life Style;Longitudinal cohort;Longitudinal Studies;maternal diabetes;Medical;Medical Care Team;member;Mental Health;Metabolic;Methodology;Methods;Mission;Molecular;Multicenter Studies;Nature;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;open source;Participant;Patients;Pediatric Hospitals;Phase;phenomics;Phenotype;Philadelphia;Physical activity;Physical assessment;physical inactivity;Plasma;Population;Prediabetes syndrome;prenatal exposure;preservation;Prevalence;prevent;Process;programs;Prospective Studies;Protocols documentation;Psychosocial Factor;Puberty;recruit;Reporting;Research;Research Design;Resources;Risk;Risk Factors;RNA;Sampling;SARS-CoV-2 infection;Science;screening;Secretory Cell;Secretory Rate;Sleep;sleep health;social health determinants;Specific qualifier value;Specificity;Standardization;study population;Teenagers;Testing;tool;Viral;Visceral;Youth

PROJECT_TITLE: Assessing Diabetes Risk Origins in Teens (ADROIT)


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Project Narrative This project will determine the role of immune signals in regulation of cardiomyocyte proliferation and heart regeneration

PI_NAMEs: SADEK, HESHAM  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Adult;Area;Biological Process;Cardiac;cardiac aging;Cardiac Myocytes;cardiac regeneration;Cell Cycle Arrest;Cell Cycle Regulation;Cell Therapy;Cells;Cessation of life;Chronic Disease;Complex;Dedications;Failure;frontier;Functional disorder;Generations;Goals;Growth;healing;Heart;Heart failure;Heart Hypertrophy;Hyperplasia;Hypertrophy;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunity;Immunologics;Immunology;Inflammatory;Injections;Injury;Innate Immune Response;interest;Investigation;Lead;Life;Link;Macrophage;Mediating;member;multidisciplinary;Muscle Cells;Myocardial;Myocardial Infarction;Myocardium;Natural regeneration;Neonatal;Pathologic;Pathology;Pathway interactions;Pattern;Physiological;Physiology;Play;postnatal;postnatal development;prevent;Process;programs;Proliferating;Regulation;repaired;Reporting;Research Personnel;response;response to injury;Role;Signal Transduction;single-cell RNA sequencing;Sterility;Stimulator of Interferon Genes;Testing;Therapeutic;Time;Ventricular Remodeling;Work

PROJECT_TITLE: Immune Response-Mediated Regulation of Cardiomyocyte Growth and Renewal

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(JA)]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PROJECT_TERMS: Adult;Agreement;Animal Experiments;Area;Bioinformatics;Biological Process;Budgets;Cardiac;cardiac aging;Cardiac Myocytes;Cardiology;Cells;Cessation of life;Child;Chronic Disease;Communication;Communities;Complex;Consultations;Data Analyses;data communication;data sharing;Experimental Designs;experimental study;Failure;frontier;Generations;Goals;Growth;healing;Heart;Heart failure;Homeostasis;Human Resources;Hyperplasia;Hypertrophy;immune activation;Immune response;Immune system;Immunity;Immunology;Individual;Injury;Institution;Intellectual Property;Investigation;Knowledge;Laboratories;Life;Link;Logistics;Manuscripts;Mediating;Medical center;meetings;member;Myocardial;Myocardium;National Heart, Lung, and Blood Institute;Natural regeneration;Neonatal;Online Systems;operation;Participant;Pathology;Pathway interactions;Physiology;Play;Postdoctoral Fellow;postnatal;Preparation;prevent;Process;programs;Progress Reports;Proliferating;Reagent;recruit;Regulation;repaired;Research;Research Personnel;Resources;response to injury;Role;Schedule;Series;Services;Signal Transduction;Students;Testing;Texas;Therapeutic;Tissues;Training;Universities;Ventricular Remodeling;web site

PROJECT_TITLE: Administrative Core (Core A)

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DAVIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Relevance to public health: Niacin (vitamin B3, a NAD+ precursor) is widely used as a food supplement to improve heath. Administration of NAD+ precursors has also been shown to ameliorate human deficiencies related to aberrant NAD+ metabolism. Our studies may provide insights into the development of therapeutic reagents for NAD+ deficiency-associated diseases such as diabetes and cancers, and also have broad implications for improving human nutrition and health.

PI_NAMEs: LIN, SU-JU  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;age related;Anabolism;Bacteria;Biochemical;Biological Models;Cell Physiology;Cells;Complex;detection of nutrient;Diabetes Mellitus;Disease;Eukaryota;Eukaryotic Cell;flexibility;Food Supplements;Genes;Genetic;Goals;Growth;Health;Homeostasis;Human;human disease;improved;insight;Knowledge;Longevity;Malignant Neoplasms;Metabolic Diseases;Metabolism;Methods;Molecular;Molecular Genetics;Niacinamide;Nicotinamide adenine dinucleotide;Nicotinic Acids;novel;Nutrient;nutrition;Pathway interactions;preservation;Proteins;Public Health;Reagent;Regulation;response;Saccharomyces cerevisiae;Saccharomycetales;Signal Pathway;Signal Transduction;System;therapeutic development;therapeutic target;transcription factor

PROJECT_TITLE: Understanding the Regulation of NAD+ Homeostasis and Signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE) Precision-CARRS seeks to transform the way we predict, prevent, and treat heart disease, stroke, and heart failure, from identifying late stage disease to earlier disease, that may be different across groups of people. We will leverage the NHLBI-funded CARRS Cohort of 21,864 adult South Asians, a population at high risk for heart disease even at young ages and who might not have obvious reasons to develop heart disease, stroke, and heart failure. Our proposed research program includes inter-connected studies that will help us understand how factors that lead to heart attacks and heart failure develop in different people and will drive a revolution of finding unique factors in people that can be targeted with suitable prevention and care strategies.

PI_NAMEs: NARAYAN, KABAYAM M VENKAT (contact);QUYYUMI, ARSHED A

PROGRAM_OFFICER_NAME: PUGGAL, MONA A

PROJECT_TERMS: acquired factor;Adult;Age;aged;Air;Air Pollution;Asia;Atherosclerosis;Automobile Driving;Behavior;behavior influence;Behavioral;biobank;Biological;Body Weight;built environment;cardiometabolic risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Caring;Cessation of life;Clinical;clinical phenotype;cohort;Collaborations;Complex;Coupling;COVID-19;Data;Data Analyses;Data Analytics;Data Collection;data management;design;Detection;Development;Diabetes Mellitus;diabetes risk;Disease;disease diagnostic;Disease Outcome;Disease Pathway;disease phenotype;disorder risk;Dyslipidemias;Environmental Exposure;Epidemiology;Etiology;Event;Fatty Liver;follow-up;Functional disorder;Funding;Future;Genetic;Goals;health assessment;Health behavior;heart disease risk;Heart Diseases;Heart failure;Heterogeneity;high risk;high risk population;Humanities;Hybrids;Immune System Diseases;improved;Incidence;India;Individual;Inflammation;innovation;insight;Investigation;Knowledge;Lead;Longitudinal cohort;Maps;Measures;Mediating;Molecular;mortality;multiple omics;Myocardial Infarction;National Heart, Lung, and Blood Institute;Natural History;Outcome Study;Pathogenicity;Pathway interactions;Pattern;Persons;Phenotype;Population;population based;Population Heterogeneity;Prevalence;prevent;Prevention;Program Research Project Grants;programs;protein biomarkers;Proteins;public health relevance;recruit;Research;Research Personnel;Resource Sharing;Resources;retention rate;Risk;Risk Factors;risk prediction;Risk Reduction;Role;Sampling;Signal Transduction;Social Behavior;social factors;social influence;South Asian;Stroke;Thinness;Time;Variant;Vascular Diseases

PROJECT_TITLE: Precision Cardiovascular Diseases Phenotyping and Pathophysiological Pathways in the CARRS Cohort (Precision-CARRS)


PI_NAMEs: ALI, MOHAMMED KUMAIL (contact)

PROJECT_TERMS: adjudication;Ancillary Study;Asia;aspirate;biobank;cardiometabolic risk;Cardiovascular Diseases;Chronic Disease;Clinical;cohesion;cohort;Collaborations;Communication;Communities;Core Grant;COVID-19 pandemic;Data;Data Analyses;Data Collection;data exchange;data handling;data management;design;disease phenotype;disorder control;Electronics;Ensure;Environmental Risk Factor;Ethics;experience;Federal Government;Feedback;Funding;Goals;Group Meetings;Growth;Health;Human Resources;Incentives;India;Infrastructure;innovation;Institution;Interdisciplinary Study;Knowledge;Laboratories;Lead;Leadership;Link;Local Government;Logistics;Manuals;Measurement;Measures;Methods;Monitor;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;Newsletter;Occupational activity of managing finances;operation;organizational structure;Outcome;outreach;Participant;Pathway interactions;Phenotype;Play;Policies;precision medicine;Principal Investigator;Process;Productivity;Program Research Project Grants;Progress Reports;Protocols documentation;Publications;Publishing;quality assurance;Quality Control;recruit;Reporting;repository;Research Personnel;retention rate;Risk Reduction;Role;Science;Scientist;Services;Site;Standardization;Strategic Planning;Structure;success;synergism;Training;United States National Institutes of Health;Universities;Update;Vision;web site;Work

PROJECT_TITLE: Administrative and Field Coordination Core


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PI_NAMEs: MOLKENTIN, JEFFERY D (contact)

PROJECT_TERMS: Acute;aorta constriction;Apical;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;Cardiovascular system;Catheters;data integration;Disease;disease phenotype;Echocardiography;Ensure;Excision;Foundations;Generations;Genes;Genetic;Growth;Heart;Heart Diseases;Heart failure;Heart Injuries;hemodynamics;Human Resources;Immune response;Injury;Intraventricular;ischemic injury;Link;Mediating;model organism;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;Myocardial Reperfusion Injury;Natural regeneration;neonatal mice;Operative Surgical Procedures;Phenotype;Physiology;pressure;Production;programs;Regulation;Reproducibility;Services;skills;Structure;Surgical Models

PROJECT_TITLE: Mouse Cardiac Physiology and Surgical Core (Core C)


ADMINISTERING_IC: DA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Rural Health;Social Determinants of Health;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The application proposes to create the UW Medical Student Addiction Research (MedStAR) program to provide opportunities for mentored research and education for medical students in 5 western rural-serving states. The MedStAR program will develop a “pipeline” for medical students who are interested in pursuing Addiction Medicine fellowships to become the next generation of physician-scientists focused on the discovery and implementation of evidence-based care for patients with substance use disorders.

PI_NAMEs: TSUI, JUDITH  (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: addiction;Address;Affect;Alaska;American;Area;Attention;Awareness;Behavior;Behavioral Research;Belief;Biomedical Research;career;Career Choice;Caring;Clinical;clinical care;Clinical Research;clinically relevant;Collaborations;college;Community Physician;Complement;Complex;Dedications;Discipline of obstetrics;Disease;Drug Addiction;early experience;Education;Education Projects;education research;Educational Activities;Eligibility Determination;Emergency Medicine;Ensure;Environment;evidence base;Evidence based practice;Evidence based treatment;experience;Faculty;falls;Family Practice;Fellowship;Funding;Future;Generations;Goals;Gynecology;hands on research;Health;HIV/HCV;Idaho;improved;Individual;interest;Internal Medicine;Knowledge;Learning;lectures;Life Expectancy;Medical;Medical Education;medical schools;medical specialties;Medical Students;Medicine;meetings;Mentors;model development;Montana;mortality;National Institute of Drug Abuse;next generation;Operative Surgical Procedures;opioid epidemic;opioid use disorder;Outcome;Patient Care;Patients;Pediatrics;Persons;Pharmaceutical Preparations;Physicians;Population;posters;programs;Psychiatry;Publications;Qualifying;Readiness;Research;Research Methodology;Research Personnel;Research Project Grants;Rural;rural area;Rural Community;Scholars Program;Scientist;Stigmatization;Students;Substance abuse problem;Substance Addiction;substance use;Substance Use Disorder;symposium;Talents;Targeted Research;Time;Training;Universities;Urban Community;Washington;Wyoming

PROJECT_TITLE: The UW Medical Student Addiction Research (MedStAR) Program to Address Substance Use and Disorders in Urban and Rural Communities in Five Western States


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Rare Diseases

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Undifferentiated pleomorphic sarcoma is a soft tissue sarcoma with one of the worst prognosis. We identified an innovative approach to treatment based on targeting a small population of tumor cells that are responsible for metastasis. This proposal will determine how this treatment approach will best work for patients with this devastating tumor type.

PI_NAMEs: ALMAN, BENJAMIN AARON (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Actins;Adult;Aftercare;alpha Tubulin;Antibodies;Automobile Driving;Bar Codes;behavior influence;Biological;Biological Process;cell motility;Cell Survival;Cells;ChIP-seq;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Deacetylase;deep sequencing;Development;Diagnosis;differential expression;Disease Progression;EGFR inhibition;Endowment;Engraftment;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Epigenetic Process;Event;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic approach;Genetically Engineered Mouse;Growth;HDAC2 gene;HDAC3 gene;Heterogeneity;high-throughput drug screening;Histone Acetylation;Histone Deacetylase;Histone Deacetylase Inhibitor;histone methylation;Human;human disease;Immunodeficient Mouse;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;innovation;insight;Interphase Cell;Invaded;Label;Libraries;limb amputation;Limb structure;Lung;lung colonization;lung volume;Malignant Fibrous Histiocytoma;Malignant Neoplasms;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;member;Metastatic Neoplasm to the Lung;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;novel;novel therapeutic intervention;organ on a chip;Outcome;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Population;Primary Neoplasm;Prognosis;Proliferating;Property;Regulation;Role;Sarcoma;self-renewal;single-cell RNA sequencing;Soft tissue sarcoma;Structure of parenchyma of lung;Tail;targeted agent;Testing;transcriptome sequencing;Transplantation;tumor;tumor growth;tumor initiation;tumor progression;tumor xenograft;Veins;Western Blotting;whole genome;Work;Xenograft procedure

PROJECT_TITLE: Targeting the metastasis initiating cell in undifferentiated pleomorphic sarcoma

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: CHANG, HOWARD H (contact)

PROJECT_TERMS: Address;analytical method;analytical tool;Area;Asia;Bayesian Modeling;biobank;Bioinformatics;Biological Markers;Biometry;Blood;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;Caring;Chronic Disease;Clinical;cohort;Collaborations;Collection;Communication;Complex;complex data;Computational Biology;Data;Data Analyses;Data Analytics;data cleaning;data complexity;data management;data platform;Data Science;Data Set;data sharing;data streams;data visualization;data-driven model;Databases;Dedications;Detection;Development;digital;disease diagnostic;disease phenotype;disorder control;disorder prevention;diverse data;Documentation;Ecological momentary assessment;Engineering;Ensure;Environment;Environmental Exposure;epidemiological model;Epigenetic Process;epigenomics;Equation;Evaluation;experience;follow-up;Funding;Goals;graduate student;Health;heterogenous data;high dimensionality;Human Resources;indexing;India;Infrastructure;innovation;Institution;International;Lead;learning strategy;longitudinal analysis;Longitudinal Surveys;Machine Learning;machine learning method;machine learning prediction;Measurement;metabolomics;Methodology;Methods;model development;Modeling;Monitor;multidimensional data;multiple omics;National Heart, Lung, and Blood Institute;Pathway interactions;Persons;Phenotype;Play;Postdoctoral Fellow;predictive modeling;Procedures;Program Research Project Grants;Protocols documentation;Public Health;Reproducibility;Reproducibility of Results;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Resources;Risk Reduction;Role;Sampling;Secure;sensor;service programs;Source;South Asian;statistical and machine learning;structured data;synergism;Techniques;Technology;Training Programs;Universities;Urine;wearable data;Work

PROJECT_TITLE: Data Management and Analysis Core


PI_NAMEs: CHEN, ZHIJIAN J (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Adult;Antibodies;Antigen-Antibody Complex;Binding;Biological Process;Cardiac;Cardiac Myocytes;Cardiovascular system;Cell Aging;Cell Cycle Arrest;Cells;Cessation of life;Chromium;Complex;Consultations;Cyclic GMP;Data Analyses;design;Digestion;DNA;Enzymes;Equipment;experience;Failure;Flow Cytometry;gain of function;Gene Expression Profiling;Generations;Genomics;Goals;Growth;healing;Heart;Heart failure;Hyperplasia;Hypertrophy;Immune;Immune response;immunocytochemistry;Immunologics;Immunologist;Immunology;Immunology procedure;Inflammatory Response;inhibitor;Injury;Innate Immune Response;innovation;interest;Interferon Type I;Interferons;Isomerism;Life;Link;Logistics;loss of function;Macrophage;Mediating;Medical center;meetings;member;Modeling;Myocardial;Natural Immunity;Natural regeneration;Neonatal;Pathway interactions;Play;postnatal;prevent;Process;Production;Productivity;programs;Proliferating;Reagent;Regulation;Rejuvenation;Research;Research Design;Research Personnel;Resource Allocation;Resources;response to injury;Role;Second Messenger Systems;sensor;Services;Signal Transduction;single-cell RNA sequencing;skills;Stimulator of Interferon Genes;success;synergism;T-Lymphocyte;Technical Expertise;Techniques;Therapeutic;Tissues;Tumor Immunity;Ventricular Remodeling;Virus;Western Blotting

PROJECT_TITLE: Cardiovascular Immunology Research Core (Core B)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The poor prognosis for this disease is due to the presence of highly invasive tumor cells that escape surgical resection. Weakly adherent cells within the tumors likely contribute to local invasion, and leveraging new cellular and molecular methods, this proposal will improve our understanding of invasion mechanisms governed by how cells adhere to their environment and suggest new therapeutic strategies.

PI_NAMEs: ENGLER, ADAM J (contact);FURNARI, FRANK

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;adhesion receptor;Adhesions;Adhesives;Adult;Affect;Astrocytes;ATAC-seq;Behavior;Biochemical;Biological Assay;Biological Models;Biophysics;Brain;brain parenchyma;Cell Adhesion;Cells;chemotherapy;ChIP-seq;Chromatin;Clinical;Co-Immunoprecipitations;Coculture Techniques;Color;Combined Modality Therapy;comparative;Complex;Contralateral;cytokine;Data;Dependence;Disease;disease prognosis;Distal;Education;Enhancers;Environment;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Epigenetic Process;Excision;Exons;Exposure to;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Fibronectins;Fluorescence-Activated Cell Sorting;Focal Adhesions;Fostering;Gene Expression;Gene Expression Profile;Gene Silencing;Genes;Genetic;Genetic Engineering;Genetic Heterogeneity;Genotype;Glioblastoma;Glioma;Heterogeneity;High-Throughput Nucleotide Sequencing;Histologic;human induced pluripotent stem cells;improved;In Vitro;in vivo;Injections;Integrins;Intervention;Invaded;Lesion;Malignant Glioma;Measurement;Mediating;Methods;migration;Modeling;Molecular;Mus;mutant;Mutate;Mutation;neoplastic cell;Neurologic;novel therapeutic intervention;Operative Surgical Procedures;paracrine;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphotransferases;Phosphotyrosine;Population;Primary Brain Neoplasms;Process;Production;Prognosis;promoter;Proteins;public database;Radiation therapy;receptor;Receptor Cell;Receptor Protein-Tyrosine Kinases;recruit;Recurrence;Role;Sampling;Serial Passage;Signal Pathway;Signal Transduction;Sorting;spheroids;Stains;System;Technology;Testing;Time;transcriptome sequencing;transmission process;tumor;Tyrosine Kinase Inhibitor;Variant

PROJECT_TITLE: Biophysical Interrogation of Signals that Drive GBM Invasion


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

PI_NAMEs: PRABHAKARAN, DORAIRAJ  (contact)

PROJECT_TERMS: adipokines;adjudication;arterial stiffness;Autopsy;Biochemical;Biological Markers;Blood;Blood Vessels;Calcium;Cardiac;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;carotid intima-media thickness;Cessation of life;Clinical;clinical phenotype;Clinics and Hospitals;cohort;Collection;Consent;Coronary;Coronary Arteriosclerosis;coronary artery calcium;Data;data acquisition;Data Analyses;Data Collection;data management;Databases;Death Certificates;Diagnosis;Disease Outcome;disease phenotype;Documentation;Elements;Equipment;Event;experience;Fatty acid glycerol esters;Fatty Liver;Functional disorder;Goals;Health;Health Care Visit;Heart failure;Hepatic;Household;immune activation;indexing;India;Inflammation;Infrastructure;Institution;International;Interviewer;Laboratories;Lead;Left;Link;Lipids;Logistics;Measurement;Measures;Metabolic;Monitor;mortality;Myocardial;Myocardial dysfunction;Myocardial Infarction;novel;Participant;participant enrollment;Pathway interactions;Peripheral arterial disease;Persons;Phenotype;phenotypic data;Physiologic pulse;Play;Process;Program Research Project Grants;Proteins;Protocols documentation;quality assurance;Quality Control;Questionnaires;Reading;Reproducibility;Research;revascularization;Risk Factors;Role;sample collection;Sampling;secondary outcome;Services;Standardization;Stress;Stroke;Structure;success;Symptoms;synergism;Techniques;Testing;thrombogenesis;Training;Transient Ischemic Attack;Transportation;Urine;Vascular Diseases;Ventricular;Visit;Work

PROJECT_TITLE: Cardiovascular Disease (CVD) Phenotyping Core


NIH_SPENDING_CATS: Congenital Structural Anomalies;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: HOUSTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: RICE UNIVERSITY

PHR: Project Narrative We propose to create models of human ectodermal development using human pluripotent stem cells, and to use these to understand the interplay between cell-cell signaling, fate patterning, and morphogenesis. As this stage of human development is almost completely inaccessible to observation and crucial for understanding birth defects and infertility, these models and the information gained will be valuable for engineering treatments for these conditions. We will use these models to gain an understanding of crucial questions about how patterns of signaling are established and interpreted in cell fate decisions and morphogenesis in order to shape the body plan.

PI_NAMEs: WARMFLASH, ARYEH  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: 3-Dimensional;Anterior;Cells;Congenital Abnormality;Development;Ectoderm;Embryo;Engineering;Ethics;Event;experimental study;Fibroblast Growth Factor;Human Development;human model;human pluripotent stem cell;implantation;Infertility;insight;intercellular communication;Lateral;Medial;Methods;Modeling;Morphogenesis;morphogens;Movement;Nervous System;Neural Crest;Neural tube;Neural Tube Closure;Organ;Organizational Models;Pathway interactions;Pattern;Recovery;Reporter;Reproducibility;self organization;Sensory;Shapes;Signal Transduction;Skin;Spontaneous abortion;System;Tissue Sample;Tissues;two-dimensional

PROJECT_TITLE: Signaling dynamics in the control of ectoderm patterning and morphogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Burden of Illness;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PI_NAMEs: QUYYUMI, ARSHED A (contact)

PROJECT_TERMS: Adverse event;Age;algorithm development;Algorithms;American Heart Association;arterial stiffness;Asia;Asian population;Atherosclerosis;biobank;Biological Markers;Blood Vessels;Body mass index;cardiometabolic risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Artery Plaques;carotid intima-media thickness;Cessation of life;Cities;Classification;Clinical;cohort;Communities;coronary artery calcium;coronary calcium scoring;Data;Data Analyses;Data Collection;data management;Development;Disease;Disease Pathway;disease phenotype;Disease Progression;Dyslipidemias;Echocardiography;EFRAC;Epigenetic Process;Equation;Ethnic Population;Evaluation;Event;Fatty acid glycerol esters;Fatty Liver;follow-up;Functional disorder;Funding;Genetic;glucose metabolism;Goals;Heart failure;Hepatic;High Prevalence;high risk;high risk population;Hypertension;Image;Immune;improved;Incidence;India;Inflammation;Lead;Left;Left Ventricular Dysfunction;Link;lipid metabolism;Lipids;Maps;Measurement;Measures;Metabolic;Myocardial;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Natural History;Necrosis;Non-Insulin-Dependent Diabetes Mellitus;novel;Participant;Pathway interactions;Persons;Phenotype;Physiologic pulse;Population;Population Study;prediction algorithm;preservation;Prevalence;Prevalence Study;Process;Program Research Project Grants;protein biomarkers;Resources;retention rate;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;Role;Sampling;South Asian;Stretching;Stroke;thrombogenesis;Vascular Diseases;Ventricular

PROJECT_TITLE: Prevalence, Incidence, and Predictors of Subclinical and Clinical Vascular and Myocardial Disease: Pathophysiologic Pathways


PROJECT_TERMS: Adult;Agonist;Binding;Biological Assay;Biological Process;Birth;Calcineurin;Cardiac Myocytes;cardiac regeneration;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;cell type;chemokine;Chromosome Segregation;Complex;Consensus;cytokine;Cytoplasm;Cytosol;Data;DNA;DNA Binding;DNA Damage;DNA Repair;Endoplasmic Reticulum;Failure;Genes;Genetic;Genetic Transcription;Growth;Heart;Heart failure;Immune response;Immune signaling;inhibitor;Innate Immune Response;IRF3 gene;Link;loss of function;Mediating;micronucleus;Mitochondria;Mitosis;Modeling;Molecular;Myocardial;Myocardium;Neonatal;Newborn Infant;NF-kappa B;Nuclear;oxidative DNA damage;Oxidative Phosphorylation;Oxidative Stress;Pathway interactions;postnatal;prevent;Process;Proliferating;Property;Proteins;Publishing;regenerative;Regenerative capacity;Regulation;response;response to injury;Role;Stimulator of Interferon Genes;System;Testing;Time

PROJECT_TITLE: Role of cGAS-STING in cardiomyocyte cell cycle regulation


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

PI_NAMEs: NARAYAN, KABAYAM M VENKAT (contact)

PROJECT_TERMS: Accounting;Address;Adult;advanced analytics;aged;Air;Air Pollution;ambient air pollution;Area;arterial stiffness;Arteries;Asia;Atherosclerosis;Biological;Biological Markers;Blood Glucose;blood pressure elevation;Body Weight;built environment;Calcium;cardiometabolic risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular effects;Carotid Artery Plaques;carotid intima-media thickness;Cessation of life;Chronic Disease;Cities;Clinical;cohort;Complex;coronary artery calcium;Cross-Sectional Studies;Data;Data Analyses;data management;density;Development;Disease;disease phenotype;Echocardiography;Environmental Exposure;Environmental Risk Factor;Equipment and supply inventories;Event;fine particles;follow-up;Functional disorder;Funding;global health;Health;Health Policy;Heart failure;high risk;Hybrids;Hypertension;Immune;improved;Incidence;Income;India;individualized prevention;Inflammation;Investigation;Knowledge;land use;Lead;Left Ventricular Dysfunction;Link;Long-Term Effects;Maps;Measurement;Measures;Mediating;Meteorology;Methods;metropolitan;mortality;multiple omics;Myocardial Infarction;Myocardial Ischemia;National Heart, Lung, and Blood Institute;Natural History;Nitrogen Oxides;Ozone;Participant;Particulate Matter;Pathogenesis;Pathway interactions;Persons;Phenotype;Pollution;Population;population based;Population Heterogeneity;predictive modeling;Prevention;Production;Program Research Project Grants;prospective;protein biomarkers;Proteins;recruit;Resolution;Risk Factors;risk prediction;Risk Reduction;Role;Sampling;social;Social Environment;sociodemographics;South Asian;spatiotemporal;statistical and machine learning;stem;Stress;Stroke;Techniques;Thick;Time;Uncertainty;United States National Institutes of Health;Vascular Diseases

PROJECT_TITLE: Environmental Exposures and the Development of Subclinical and Clinical Vascular and Myocardial Disease


NIH_SPENDING_CATS: Brain Disorders;Cancer;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE  This project is relevant to human health, as mutations in human PCDH19 cause a female-limited form of epilepsy and are associated with an increased incidence of other brain disorders. In addition, other δ-pcdhs to be studied in this proposal (pcdh7, pcdh9, pcdh17 and pcdh18) have been implicated in autism or schizophrenia. This gene family has also been linked to a variety of cancers as putative tumor suppressors that are downregulated in cell lines or primary tumors. Moreover, PCDH1 is linked to asthma. Understanding the function these genes in neurogenesis could provide important insights into the origins of neurodevelopmental disorders and provide novel drug targets in cancer.

PI_NAMEs: JONTES, JAMES DAVID (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Adhesives;Affect;Asthma;autism spectrum disorder;beta catenin;Brain;Brain Diseases;cancer risk;Cell Adhesion Molecules;cell behavior;Cell Communication;Cell Differentiation process;Cell division;Cell Line;cell motility;Cell Physiology;Cell Proliferation;cell type;Cell-Cell Adhesion;Cells;Complex;Data;Defect;Development;developmental disease;Disease;Epilepsy;Event;experimental study;Family;family influence;Female;Gene Family;gene function;Gene Mutation;Genetic;Goals;Health;Human;human disease;Image;in vivo;Incidence;Individual;insight;Lateral;Link;Malignant Neoplasms;mature animal;Mechanics;Mediating;member;Molecular;Mosaicism;mutant;Mutation;nerve stem cell;Nervous System;nervous system development;neural circuit;Neural tube;neurodevelopment;Neurodevelopmental Disorder;Neuroepithelial;Neuroepithelial Cells;neuroepithelium;neurogenesis;Neurons;new therapeutic target;Organism;Primary Neoplasm;Process;Production;Proliferating;Protein Family;Proteins;protocadherin 19;rational design;receptor;Role;Schizophrenia;Signal Transduction;spatiotemporal;stem cell division;stem cell proliferation;stem cells;superior colliculus Corpora quadrigemina;Testing;Therapeutic;Time;Tumor Suppressor Genes;Tumor Suppressor Proteins;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Protocadherin control of cell proliferation and differentiation

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Precision Medicine;Prevention

PI_NAMEs: SUN, YAN  (contact)

PROJECT_TERMS: 20 year old;acquired factor;Age;Algorithms;ambient air pollution;arterial stiffness;Asia;Atherosclerosis;Biological Process;cardiometabolic risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Caring;Carotid Artery Plaques;carotid intima-media thickness;Cessation of life;Clinical;clinical phenotype;cohort;Collection;Complex;Coronary Arteriosclerosis;coronary calcium scoring;design;Detection;Development;Diabetes Mellitus;Disease;Disease Management;Disease Outcome;disease phenotype;disorder risk;Dyslipidemias;Echocardiography;EFRAC;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Evaluation;Feasibility Studies;follow-up;Functional disorder;Funding;Gene Expression;Genes;Genetic;genetic risk factor;Genetic Variation;genome wide association study;genomic locus;Genomics;Goals;Heart failure;High Density Lipoprotein Cholesterol;High Prevalence;human disease;Hypertriglyceridemia;improved;India;Individual;inter-individual variation;Investigation;Ischemia;Joints;Lead;Left;Link;Low Prevalence;machine learning algorithm;Measurement;Measures;Mediating;Mendelian randomization;metabolome;metabolomics;Methods;Modification;Molecular;multiple omics;Myocardial Infarction;National Heart, Lung, and Blood Institute;Natural History;novel;Obesity;Participant;Pathway interactions;personalized diagnostics;Phenotype;Physiological;Play;Population;population based;Population Study;precision medicine;predictive marker;predictive modeling;preservation;Prevention;Program Research Project Grants;response;Risk;Risk Assessment;Risk Factors;risk prediction;Risk Reduction;Role;Sampling;small molecule;South Asian;synergism;Technology;Testing;Time;Vascular Diseases;Ventricular;Visit

PROJECT_TITLE: Epigenomic and Metabolomics Determinants of Subclinical and Clinical Vascular and Myocardial Disease


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: ITHACA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative (relevance) Many human diseases arise from defects in the subcellular membrane and protein sorting machinery and its regulators. This project investigates the function and regulatory mechanisms of key proteins controlling sorting that are essential for cell viability.

PI_NAMEs: FROMME, J CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemical;Biological;Biological Assay;Cell membrane;Cell Survival;Cells;Communication;Defect;Destinations;Endoplasmic Reticulum;Endosomes;Eukaryotic Cell;Experimental Genetics;experimental study;Family;genetic approach;glycosylation;Golgi Apparatus;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;human disease;In Vitro;in vivo;live cell imaging;Logic;Lysosomes;Membrane;Membrane Protein Traffic;Molecular;mutant;Nucleotides;Organelles;Pathway interactions;Physiological;Process;programs;protein protein interaction;Protein Sortings;Proteins;Proteomics;Reaction;reconstitution;recruit;Regulation;Research;Role;Signal Transduction;Site;Sorting;structural biology;tool;trafficking;Vesicle;Visualization;Work

PROJECT_TITLE: GTPase Regulation of the Golgi Complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

PHR: Narrative The proper alignment of internal circadian clocks with the 24-hour rhythm of the environment is critical for human health. A central goal of chronobiology is to understand the network properties of brain’s master clock and its modulation by environmental cues. Here we use Drosophila melanogaster, an organism that continues to enrich and inform our understanding of circadian timekeeping in the brain, to understand the signals neurons use to create an internal sense of time and how the microanatomical structures of neuronal clocks support robust circadian timekeeping and the proper synchronization with the environment.

PI_NAMEs: SHAFER, ORIE T (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TITLE: Micro-Anatomical Mechanisms of Neuronal Circadian Timekeeping, Output, and Entrainment

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Heart Disease;Nutrition;Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: PATEL, SHIVANI A (contact)

PROJECT_TERMS: Adult;Affective;Age;aged;Air;Air Pollution;Algorithms;Asia;Atherosclerosis;Behavior;Behavioral;Blood;Blood Glucose;Blood Pressure;Body mass index;built environment;cardiometabolic risk;Cardiomyopathies;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cessation of life;Characteristics;Cholesterol;Clinical;clinical risk;cohort;Communities;contagion;coronary calcium scoring;Data;design;Development;Diabetes Mellitus;Diet;Disease;disease phenotype;Early Diagnosis;Early identification;Ecological momentary assessment;Education;Enrollment;Environment;Environmental Exposure;Environmental Risk Factor;experience;Family;Fasting;Funding;Future;Geography;Health;Health behavior;Household;Hypertension;improved;Incidence;India;Individual;Intervention;Investigation;Lead;Life Style;longitudinal analysis;longitudinal design;man;Marriage;Measures;Mental Depression;mHealth;Myocardial Infarction;National Heart, Lung, and Blood Institute;Natural History;novel;Outcome;Overweight;Pathway interactions;Phenotype;Physical activity;Polysomnography;population based;Population Heterogeneity;prediction algorithm;psychosocial;Psychosocial Factor;Random Allocation;real time monitoring;Recording of previous events;recruit;Research;Research Personnel;Resource Sharing;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;Role;Sampling;Science;Sleep;smartphone application;social;social determinants;Socioeconomic Factors;South Asian;Spouses;Stress;Stroke;synergism;Technology;Time;Vascular Diseases;wearable device;Woman;wristband

PROJECT_TITLE: Spousal Influences on Subclinical and Clinical Vascular and Myocardial Disease


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Repetitive negative thinking (RNT) is a core cognitive process central to the etiology and maintenance of many forms of psychopathology. Given that the presence of RNT undermines treatment outcomes, an urgent unmet need is to understand the precise psychological targets and neural systems underlying RNT that could be engaged in treatment. Thus, this project takes an experimental therapeutics approach to assess: (a) target engagement of attentional/cognitive control (as measured by eye tracking, event related potentials, and self- report data), (b) preliminary treatment efficacy of a transdiagnostic treatment for elevated RNT optimized to address attention regulation, and (c) whether improvements in attentional/cognitive control are associated with improved RNT and disorder-specific symptoms (i.e., target validation).

PI_NAMEs: JACOBY, RYAN J (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affective;affective neuroscience;Aftercare;Anxiety;Area;associated symptom;Attention;attentional control;Behavioral;biobehavior;biobehavioral measurement;career development;Clinical;clinical translation;Clinical Trials;Cognitive;cognitive control;cognitive process;Cognitive Therapy;comorbidity;Conflict (Psychology);Control Groups;cue reactivity;Cues;Data;Data Reporting;depressive symptoms;Development Plans;Diagnostic;Disease;Dose;Electrophysiology (science);emotion regulation;Emotional;emotional stimulus;EP300 gene;Etiology;Event-Related Potentials;Exposure to;Failure;flexibility;follow-up;Fright;Functional impairment;Funding;Generalized Anxiety Disorder;Goals;Health Care Costs;Impairment;improved;indexing;Individual;individual response;Intervention;Investigational Therapies;Learning;Maintenance;Major Depressive Disorder;Measurement;Measures;Mediation;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Monitor;Mood Disorders;National Institute of Mental Health;Nature;neural;Obsessive-Compulsive Disorder;Outcome;overtreatment;P300 Event-Related Potentials;Patient Self-Report;Patients;Positioning Attribute;Process;Protocols documentation;Psyche structure;psychologic;Psychopathology;Psychotherapy;Public Health;Randomized;Randomized, Controlled Trials;Reaction Time;Refractory;Regulation;Research;Research Domain Criteria;Residual state;response;Rest;Risk;Ritual compulsion;rumination;sample fixation;Science;Scientist;Severities;skills;source localization;Specificity;statistics;stressor;sustained attention;Symptoms;System;temporal measurement;Testing;Theoretical model;Therapeutic;Thinking;Training;Treatment Efficacy;treatment optimization;Treatment outcome;treatment response;Uncertainty;Validation;validation studies;visual tracking

PROJECT_TITLE: Targeting Attentional and Cognitive Control to Enhance the Transdiagnostic Treatment of Repetitive Negative Thinking


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy

PI_NAMEs: HILL, JOSEPH A (contact)

PROJECT_TERMS: Abbreviations;adaptive immune response;antagonist;Antigen Presentation;Antigen-Presenting Cells;antimicrobial;Apoptosis;Atherosclerosis;Atrial Fibrillation;cancer complication;cancer immunotherapy;Cardiac;Cardiac Myocytes;Cardiovascular system;CD27 Antigens;CD28 gene;CD80 gene;CD86 gene;Cell Physiology;cell type;Cells;Clinical;Clinical Trials;Collaborations;Core Facility;CTLA4 gene;CXCL9 gene;Cyclic GMP;Cytosol;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;Development;DNA;ds-DNA;Elements;Event;Extracellular Matrix;Failure;Fibroblasts;Fibrosis;Functional disorder;Goals;Growth;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Homing;hypertensive heart disease;Hypertrophic Cardiomyopathy;Hypertrophy;Immune;Immune response;Immunomodulators;Immunotherapy;Inflammatory;insight;Interferons;Intervention;Knowledge;Knowledge acquisition;Ligands;Macrophage;Malignant Neoplasms;Mediating;Molecular;Myocardial Infarction;Myocardial Ischemia;novel;pathogen;Pathway interactions;Patients;Pattern;pharmacologic;Population;pressure;Process;Production;programmed cell death protein 1;programs;Reaction;Reading;Reagent;recruit;Regulation;Reporting;Research Design;response;Role;Second Messenger Systems;sensor;Series;Signal Transduction;Stimulator of Interferon Genes;STING agonists;Stress;T cell regulation;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;targeted treatment;TCR Activation;Testing;tool;Translations;Up-Regulation;Ventricular Arrhythmia;ventricular hypertrophy;Ventricular Remodeling;Work

PROJECT_TITLE: Role of cGAS-STING in Afterload-Induced Cardiac Remodeling


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Low-density lipoprotein cholesterol (LDL-C) is a causative factor in the development of atherosclerotic cardiovascular disease (ASCVD), and lipid-lowering therapy can markedly reduce this risk. Yet, exactly when to begin lipid-lowering therapy has not been well understood. Despite the increasing rates of ASCVD in US young adults aged 18-39 years over the past two decades, use of lipid-lowering therapy remained low, with <7% of young adults with LDL-C ≥160 mg/dL being treated (vs. ~50% in those aged ≥40 years). It is estimated that 52% US young adults have non-optimal LDL-C ≥100 mg/dL and 7% have LDL-C ≥160 mg/dL. However, there is little evidence to guide lipid management in young adults, partly due to the lack of empirical evidence. We propose to study ~805,000 young adults from 4 cohort studies (CARDIA, Framingham, HCHS/SOL, JHS) and Kaiser Permanente Southern California to identify more effective lipid-lowering and ASCVD prevention strategies and reduce health inequity in young adults.

PI_NAMEs: AN, JAEJIN ;ZHANG, YIYI  (contact)

PROGRAM_OFFICER_NAME: MUSSOLINO, MICHAEL EUGENE

PROJECT_TERMS: Address;Adolescence;Adult;Adverse event;Age;age group;Age Years;aged;Algorithms;Assessment tool;Atherosclerosis;California;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Clinical Trials;clinically actionable;clinically relevant;cohort;Cohort Studies;cost;cost effective;Data;Databases;Development;Diabetes Mellitus;Disease Outcome;Early Intervention;Economics;emerging adult;enhancing factor;Equation;ethnic diversity;Event;experience;Family history of;follow-up;Future;Goals;Guidelines;Health;health equity;health inequalities;healthy aging;Hereditary Disease;high risk;Hyperlipidemia;improved;late life;LDL Cholesterol Lipoproteins;Life Style;Life Style Modification;lifestyle intervention;lifetime risk;Lipids;Lipoprotein (a);Metabolic syndrome;Myocardial Infarction;Not Hispanic or Latino;older adult;Patients;Performance;Persons;Policy Maker;Population;Population Heterogeneity;premature;prevent;Prevention;Prevention strategy;Prior Therapy;Qualifying;racial diversity;randomized trial;Recommendation;Risk;Risk Assessment;Risk Estimate;Risk Factors;risk prediction model;Selection Bias;simulation;Smoking;Smoking History;social health determinants;Statistical Models;Subgroup;Time;treatment risk;young adult

PROJECT_TITLE: Improving Lipid Management Strategies in Young Adults

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Asthma;Childhood Obesity;Clinical Research;Eczema / Atopic Dermatitis;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Obesity;Pediatric;Social Determinants of Health

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Children and adolescents with asthma living in urban settings suffer from increased disease severity, morbidity and mortality; the NIAID has provided long-standing support of networks to implement improved approaches to care for this at-risk population. Our objective is to demonstrate that the Mount Sinai Health Care System is well-positioned and prepared to create a NIAID Childhood Asthma in Urban Settings Clinical Research Network Center (CAUSE-CRC). We are proposing two Center-studies, which address how the co-morbidities of atopic dermatitis (Project 1) and obesity (Project 2) worsen asthma control in an urban pediatric population, findings of which will guide interventions to improve their outcomes.

PI_NAMEs: BUNYAVANICH, SUPINDA ;BUSSE, PAULA J (contact);WISNIVESKY, JUAN P

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;Adolescent;Adolescent obesity;airway inflammation;Allergens;Allergic Disease;Area;Arginine;Asthma;Atopic Dermatitis;Blood;burden of illness;Caring;Child;Childhood;Childhood Asthma;Clinical;Clinical Research;Collaborations;comorbidity;Cutaneous;Data;Dietary Supplementation;Disease;Ensure;Environmental Exposure;Epidemiology;Equilibrium;Ethnic Origin;experience;Extrinsic asthma;Funding;Future;health care disparity;Health system;Healthcare Systems;high risk;high risk population;Hospitals;Hypersensitivity;Immune response;Immunology;Impairment;improved;Individual;Inflammation;innovation;Institution;interest;Intervention;Intervention Studies;Laboratories;Laboratory Technicians;Lead;Literature;member;metropolitan;Microbe;microbiome;Minority Groups;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;New York City;Nitric Oxide;novel;novel therapeutics;Nurses;Obesity;Outcome;Pathogenicity;Pathway interactions;Pattern;personalized therapeutic;Pharmacists;Phenotype;Population;Populations at Risk;Positioning Attribute;Poverty;Process;programs;prospective;Proteomics;Protocols documentation;Qualifying;recruit;Research;Research Contracts;Research Personnel;Research Project Grants;research study;respiratory;Risk;Risk Factors;Sampling;Self Management;Severity of illness;Site;Skin;success;support network;Systems Biology;transcriptomics;United States National Institutes of Health;urban children;urban minority;Urban Population;urban setting;Work

PROJECT_TITLE: Childhood Asthma in Urban Settings


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Narrative Innovative new technologies that enable experimentally robust interrogation of epigenetic mechanisms are needed to broaden our understanding of epigenetic regulatory pathways in human development, disease, and therapeutic resistance. Formalin fixed, paraffin embedded (FFPE) tissues contain a wealth of information on human disease, however, extraction of high-quality chromatin (DNA together with associated nuclear proteins) from these samples for use in epigenetic assays has proven virtually impossible. We will explore the use of a unique cavitation enhancement reagent in simplifying and standardizing chromatin extraction from FFPE tissues, with the goal of making archived biospecimens available for a broad range of epigenetic-based biomedical research.

PI_NAMEs: DAVIS, IAN J;PATTENDEN, SAMANTHA GAIL (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Acoustics;Address;Architecture;autism spectrum disorder;Biological;Biological Assay;biological specimen archives;Biology;Biomedical Research;Cell Nucleus;cell type;Cells;Cellular Assay;Chemicals;Chromatin;chromatin immunoprecipitation;Consumption;crosslink;Data;Dehydration;Development;Devices;Diagnostic;Disease;Disease Resistance;DNA;DNA Fragmentation;DNA Packaging;DNA-Protein Interaction;driver mutation;Enhancement Technology;Epigenetic Process;Epilepsy;Formaldehyde;Formalin;Formulation;Genomic DNA;Goals;Heating;Heterogeneity;Histones;Human;Human Development;human disease;innovation;Intellectual functioning disability;invention;Legal patent;Link;Malignant Neoplasms;Methods;Mutation;nanoDroplet;Nervous System Disorder;new technology;next generation sequencing;Nuclear Proteins;Nucleic Acids;Nucleosomes;Paraffin Embedding;parallel processing;Pattern;preservation;prevent;programs;Proteins;Protocols documentation;Reagent;Regulation;Regulatory Pathway;Reproducibility;Research;sample fixation;Sampling;Sonication;Specimen;Standardization;Syndrome;Techniques;Technology;therapy resistant;Time;tissue archive;Tissue Banks;Tissue Embedding;Tissue Sample;Tissues;tumor;virtual

PROJECT_TITLE: Development of a cavitation enhancement technology to access archived tissues for epigenetic-based biomedical research

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CORAL GABLES

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative While sebaceous glands in our skin secrete an oily film (sebum) for skin lubrication, have multiple other indispensable functions, and are involved in many skin diseases, it is still quite unclear how they are regulated. Therefore, we aim to identify the role of a powerful regulatory protein located in mitochondria, the energy power houses of our cells, called MPZL3, in regulating sebaceous gland function, using state-of-the-art mouse and human skin research tools. Besides helping us to better understand how healthy sebaceous gland functions are regulated, the innovative skin research focusing on MPZL3 proposed here also promises to identify novel drug targets for more effective and better-tolerated treatment of human skin diseases with prominent sebaceous gland abnormalities such as acne, dry skin, scarring alopecia (hair loss) and sebaceous carcinoma.

PI_NAMEs: PAUS, RALF ;WIKRAMANAYAKE, TONGYU CAO (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: 3-Dimensional;Acne;Acne Vulgaris;adipokines;Adipose tissue;Agonist;Alopecia;antagonist;Biology;c-myc Genes;Cells;Cicatrix;Clustered Regularly Interspaced Short Palindromic Repeats;Critical Pathways;Data;Dermal;Dermis;Differentiation Antigens;druggable target;Dryness;Elasticity;Elements;Endocrine;Epithelium;FASN gene;Film;Genes;genetic regulatory protein;Genetic Transcription;gland development;Gonadal Steroid Hormones;Hair;Histocytochemistry;Homeostasis;Hormones;Human;Hyperplasia;Immunologics;In Situ Hybridization;In Vitro;in vivo;in vivo Model;innovation;insight;knock-down;Knock-out;Knockout Mice;Label;laser capture microdissection;lipid biosynthesis;lipid metabolism;lipidomics;Lipids;Lubrication;Luciferases;Mass Spectrum Analysis;Mediating;Metabolic;microbiome;Mitochondria;Mitochondrial Proteins;Molecular;Mus;Myelin P0 Protein;new therapeutic target;novel;Nuclear;Organ Culture Techniques;Organoids;overexpression;Pathology;Pathway Analysis;Pathway interactions;Phenotype;Physiologic pulse;Physiologic Thermoregulation;Physiology;PRDM1 gene;Production;Proliferating;Proteins;Proteomics;Quantitative Reverse Transcriptase PCR;Reactive Oxygen Species;Regulation;Reporter;Research;Research Project Grants;RNA;Role;Scalp structure;Sebaceous Adenocarcinoma;Sebaceous Gland Neoplasms;Sebaceous Glands;Seborrheic dermatitis;Sebum;Signal Transduction;Skin;skin barrier;skin disorder;skin microbiome;Small Interfering RNA;Testing;Therapeutic Intervention;Therapeutically Targetable;Tissues;tool;transcriptome sequencing;Translational Research

PROJECT_TITLE: MPZL3 as a Therapeutically Targetable Mitochondrial Regulator of Sebaceous Gland Homeostasis and Sebum Production

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

PI_NAMEs: OLSON, ERIC N (contact)

PROJECT_TERMS: Ablation;Acute;adaptive immune response;adaptive immunity;Adult;Affect;angiogenesis;Anti-Inflammatory Agents;Apoptosis;Binding;Cardiac;Cardiac Myocytes;cardiac regeneration;cardiac repair;CCL24 gene;Cell Proliferation;Cell secretion;Cells;cytokine;Cytokine Receptors;Development;Dichloromethylene Diphosphonate;gain of function;Generations;Genetic;Growth;Heart;Helper-Inducer T-Lymphocyte;Human;Immune;immune activation;Immune response;Immune signaling;Immune system;Impairment;in vivo;Inflammatory;Inflammatory Response;Injury;injury recovery;Interleukin 4 Receptor;Interleukin-4;Liposomes;loss of function;Macrophage;Maps;Mediating;Mediator;Mus;Myocardial Infarction;Natural Immunity;Natural regeneration;Neonatal;neonatal mice;Outcome;Pathway interactions;Phenotype;Population;Process;Production;Proliferating;receptor;Receptor Signaling;recruit;regeneration following injury;Regenerative capacity;Regulation;repaired;response to injury;Role;Signal Pathway;Signal Transduction;Surface;T-Lymphocyte;Testing;Therapeutic;Tissues;tool

PROJECT_TITLE: T-Cell-Mediated Inflammatory Response in Neonatal Heart Regeneration


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Services;Heart Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Acute heart failure is a common reason for emergency department visits and hospitalization, but the diagnosis can be challenging because of non-specific symptoms and signs. The current diagnostic approach to acute heart failure has modest accuracy, leading to delayed diagnosis and treatment, which associate with worse prognosis. Our prior work suggests diagnostic accuracy can be improved with the addition of multiple circulating biomarkers discovered through proteomics, and herein we propose to derive and validate a multi- marker model to improve diagnostic accuracy for acute heart failure in the emergency department.

PI_NAMEs: COLLINS, SEAN PATRICK;GUPTA, DEEPAK  (contact)

PROGRAM_OFFICER_NAME: POOL, LINDSAY REGINA

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Acute;Address;adjudication;adverse outcome;Affect;American;Antibiotics;Asthma;base;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker panel;biomarker selection;Bronchodilator Agents;Calibration;candidate selection;Cardiac;Chronic Obstructive Pulmonary Disease;circulating biomarkers;Clinical;Clinical Data;clinical diagnostics;clinical practice;clinical predictive model;cohort;Congestive Heart Failure;cost;Data;Derivation procedure;Diagnosis;diagnosis standard;diagnostic accuracy;diagnostic strategy;Diagnostic tests;Discrimination;Diuretics;Dyspnea;EFRAC;Elasticity;Emergency department visit;Enrollment;Frequencies;Future;Guidelines;health care service utilization;Heart failure;Hospitalization;improved;Investigation;IV Fluid;Knowledge;Left Ventricular Ejection Fraction;Logistic Models;Medicare;Modeling;mortality;Natriuretic Peptides;novel;novel diagnostics;novel marker;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Performance;performance tests;Plasma;Pneumonia;predictive modeling;preservation;Probability;Prognosis;prospective;protein biomarkers;Proteins;Proteomics;Recommendation;Recording of previous events;recruit;Reporting;Research Design;respiratory;Sample Size;Sampling;Shortness of Breath;Signs and Symptoms;Specificity;Symptoms;Testing;Thoracic Radiography;Validation;Work

PROJECT_TITLE: Improving Diagnostic Accuracy for Acute Heart Failure

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Digestive Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative    The cellular pathophysiology of gastrointestinal motility disorders are extremely complex and elusive.  Damage  or  loss  of  enteric  inhibitory  motor  neurons  is  responsible  for  a  broad  range  of  gut  motility  disorders.  Here,  taking  advantage  of  human  pluripotent  stem  cell  differentiation,  we  propose  to  establish  an  innovative  framework  to  establish  a  new  cellular  model  for  the  study  enteric  inhibitory  neurons and an experimental pipeline for cell replacement therapy in GI dysmotility.

PI_NAMEs: FATTAHI, FARANAK  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adult;Affect;Behavior;Brain;Cell model;cell replacement therapy;Cell Therapy;cell type;Cells;Chemicals;clinical phenotype;Complex;Congenital Megacolon;Cues;Defect;Derivation procedure;Development;Disease;disease model;Dissection;drug discovery;Engraftment;Enteral;Enteric Nervous System;enteric neuropathy;Enzymes;Esophageal achalasia;Experimental Models;follow-up;Functional disorder;gastrointestinal;Gastrointestinal Motility;Gastroparesis;Goals;Human;human pluripotent stem cell;Hypertrophic Pyloric Stenosis;in vitro Model;infancy;inhibitory neuron;innovation;Intestinal Motility;Investigation;Knockout Mice;Link;Maps;Medical;Modeling;Motility;motility disorder;Motor Neurons;mouse model;Mus;Muscle;Nervous System Disorder;neuron component;Neuronal Differentiation;Neurons;Neurosphere;Neurotransmitters;Nitrergic Neurons;Nitric Oxide;Nitric Oxide Synthase Type I;Pathway interactions;Patients;Pattern;pharmacologic;Play;pluripotent stem cell differentiation;Population;Population Heterogeneity;Process;Production;prospective;reconstruction;regeneration potential;regenerative;Regulation;Relaxation;Reporting;Research;response;Role;screening;small molecule;Smooth Muscle;Specific qualifier value;Spinal Cord;Stimulus;Study models;Surface Antigens;System;Therapeutic Intervention;therapeutically effective;Time;Tissues;transcriptomics;Transplantation;treatment strategy

PROJECT_TITLE: Human pluripotent stem cells for the study of gastrointestinal dysmotility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-T(90)]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PI_NAMEs: MOLKENTIN, JEFFERY D (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acute;Adopted;adult stem cell;Apoptosis;Area;Atherosclerosis;Bacteria;Basic Science;Bioinformatics;Biology;Blood Vessels;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;Cell secretion;Cell Therapy;cell type;Cells;Cicatrix;Clinical Data;Clinical Trials;Collaborations;Compensation;Complement Activation;Data;Dendritic Cells;Disease;DNA;Endothelial Cells;Event;Fibroblasts;fungus;Genes;genetic manipulation;Goals;Growth;healing;Heart;Heart failure;Heart Injuries;Human;Immune;Immune response;Immune signaling;improved;Infarction;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Infusion procedures;Injection of therapeutic agent;Injections;injured;Injury;innate immune mechanisms;Innate Immune Response;ischemic injury;life span;Literature;Macrophage;Mediating;mouse genetics;Mus;Muscle Cells;Myocardial Infarction;Natural regeneration;Nature;Neurosecretory Systems;neutrophil;novel;novel therapeutics;Outcome;paracrine;Pathway interactions;Patients;Pattern recognition receptor;physical property;Production;protective effect;Proteins;Regulation;Rejuvenation;repaired;Reporting;Reproducibility;Research;response;response to injury;RNA;Rodent Model;Signal Pathway;Signal Transduction;stem cell therapy;stem cells;Stimulator of Interferon Genes;Structure;Therapeutic;Therapy trial;Tissue Expansion;Tissues;Toll-like receptors;transdifferentiation;Uncertainty;Virus;Western World;Work

PROJECT_TITLE: Innate Immune Response in Cardiac Healing and Rejuvenation


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Eye Disease and Disorders of Vision;Immunization;Neurosciences;Vaccine Related

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Chronic autoimmune uveitis is a prevalent intraocular inflammatory disease, with the potential of causing severe visual impairment and blindness including in young adults, leading to an oversized public health burden. The clinical management of patients with chronic uveitis is challenging due to the limited availability of efficacious treatments, primarily due to our poor understanding in the immunopathogenesis of this condition. We propose to determine the novel immunological memory-mediated mechanisms in sustaining disease chronicity, with the objective of improving our understanding of disease pathogenesis and facilitating future translational studies.

PI_NAMEs: CHEN, YIHE  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Acute;Acute Disease;Address;Adrenal Cortex Hormones;Adult;Age;Animals;antigen-specific T cells;Antigens;Apoptosis;Autoimmune Diseases;autoimmune uveitis;autoreactivity;beta catenin;Biological Assay;Biology;Blindness;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Physiology;Cell Survival;Cells;Chronic;Chronic Disease;Clinical;Clinical Management;Data;Dependence;Development;Disease;Disease Resistance;Economic Burden;economic impact;efficacious treatment;Electroretinography;experimental study;Flow Cytometry;Future;Genetic Transcription;glucose uptake;Glycolysis;Health Care Costs;Histopathology;Human;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immune response;Immunologic Memory;Immunotherapeutic agent;improved;In Vitro;in vivo;Incidence;Individual;Infiltration;Inflammation;Inflammatory;Knowledge;Laboratories;Longevity;Mediating;Mediator;Medical;memory CD4 T lymphocyte;memory recall;Metabolic;Metabolic Pathway;Metabolism;Modeling;Molecular;mouse model;novel;novel therapeutic intervention;overexpression;Oxygen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Play;Population;productivity loss;Proliferating;Proteins;Public Health;Resistance;response;Retina;Role;sensor;Severity of illness;side effect;socioeconomics;T memory cell;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tissues;transcriptional reprogramming;Transgenic Mice;Transgenic Model;translational study;Up-Regulation;Uveitis;Viral Cancer;Virus Diseases;Vision;Visual impairment;Western Blotting;Work;young adult

PROJECT_TITLE: Mechanisms of immunological memory-mediated pathogenesis in chronic autoimmune uveitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Neurosciences;Women's Health Research

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative Brain metastases are a growing problem across cancers. They can take many years to manifest, but are lethal once they do. Here, we propose to investigate breast tumor cells upon their arrival to the brain in order to define the cues that make them dormant, and to unravel the consequent signaling. We believe that solving these mysteries will inspire approaches to prevent brain metastasis by leveraging our discoveries for prophylactic therapies.

PI_NAMEs: GHAJAR, CYRUS M (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Ablation;Address;Agonist;Agrin;Articulation;Astrocytes;Autopsy;Basement membrane;Binding;Blood Vessels;bone;Bone Marrow;Brain;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;Cancer Patient;Cell Proliferation;cerebrovascular;Clinical;Clinical Data;Cues;Curiosities;Data;Deposition;Development;Disease;Dystroglycan;Early Diagnosis;Enzymes;glycosylation;Goals;high dimensionality;Human;in vivo;Individual;innovation;intravital imaging;Investigation;knock-down;Laminin;Lesion;Liver;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;metastasis prevention;Metastatic breast cancer;Metastatic malignant neoplasm to brain;mouse model;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;Organ;Outcome Measure;Ovary;palliative;Pathway interactions;Patients;Penetrance;Phase;prevent;prophylactic;Publishing;receptor;Recording of previous events;Resources;Seminal;Signal Transduction;Signaling Molecule;Site;Soil;Specimen;Suppressor-Effector T-Lymphocytes;Systemic Therapy;Testing;theories;Therapeutic;Time;Transgenic Mice;Transgenic Model;Woman;Work;Xenograft Model

PROJECT_TITLE: Defining and characterizing microenvironmental drivers of disseminated tumor cell dormancy in brain

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative Patients with dilated, nonischemic cardiomyopathy (DCM), even in the absence of severe cardiac dysfunction, may be at high risk for life-threatening ventricular arrhythmias and sudden cardiac death. However, current paradigms are insufficiently sensitive to correctly identify patients with ‘arrhythmogenic’ DCM who are at risk. Our application is built around this unmet need: we will generate a ‘risk stratification score’ that can be used as a clinical tool, uncover the molecular mechanisms triggering arrhythmias in these patients, which are currently unknown, and dissect the mechanisms of lethal fibrosis, thus paving the way for development of novel therapeutic strategies.

PI_NAMEs: MESTRONI, LUISA  (contact);TAYLOR, MATTHEW R

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Age;Arrhythmia;Basic Science;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cells;Circulation;Clinical;Clinical Data;clinical predictors;Clinical Sciences;cohort;Cohort Studies;Colorado;coronary fibrosis;Data;design;Development;Dilated Cardiomyopathy;Disease;Early identification;Ethnic Origin;experimental study;Fibroblasts;Fibrosis;filamin;FLNC gene;Foundations;Gender;Gene Expression Profile;Gene Mutation;Genes;Genetic;genetic predictors;genome editing;genome sequencing;Genomics;Genotype;Goals;Heart;heart rhythm;high risk;human induced pluripotent stem cells;Image;Implantable Defibrillators;implantation;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;interdisciplinary approach;Knowledge;Left Ventricular Ejection Fraction;Life;Malignant - descriptor;Modeling;Molecular;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;mutant;Mutation;Myocardial dysfunction;National Heart, Lung, and Blood Institute;Nature;next generation sequencing;novel;novel therapeutic intervention;Outcome Measure;Pathogenicity;Pathway interactions;Patients;pharmacologic;Phenotype;Population;precision medicine;Prevention;Preventive;Prognosis;Registries;Reporting;Research Personnel;Risk;risk prediction;risk stratification;Role;Science;Signal Pathway;Signal Transduction;Societies;sudden cardiac death;therapeutic target;tissue support frame;Tissue-Specific Gene Expression;tool;Trans-Omics for Precision Medicine;transcriptome;transcriptome sequencing;Translating;Translational Research;United States National Institutes of Health;Universities;Variant;Ventricular Arrhythmia;whole genome;Work

PROJECT_TITLE: Elucidating the Origin of Sudden Cardiac Death in Dilated Cardiomyopathy: from Phenotype Predictors to Therapeutic Targets

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Primary Health Care

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

PHR: Screening for autism spectrum disorder (ASD) during well-child pediatric check-ups reduces the age of diagnosis, allowing more time for critical early intervention. This study will follow up screen negative cases to detect children with ASD missed by screening, to calculate sensitivity of toddler screening. This will lead to improvements in detecting and treating ASD as early as possible.

PI_NAMEs: ROBINS, DIANA L (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 14 year old;3 year old;8 year old;Academy;Address;Age;Age disparity;aged;American;autism spectrum disorder;autism symptoms;autistic children;Benefits and Risks;Characteristics;checkup examination;Child;Childhood;Classification;Clinical;clinical diagnosis;clinically significant;cohort;Communities;Complement;cost;Data;Detection;Diagnosis;disorder risk;Disparate;disparity reduction;Early Diagnosis;Early Intervention;early screening;Education;Enrollment;Evaluation;Female;follow-up;Goals;Health;improved;Literature;male;Masks;Measures;Medical Records;Methods;Minority;Modified Checklist for Autism in Toddlers;Outcome;Parents;Participant;Pattern;Pediatrics;Positioning Attribute;Prevalence;Primary Care;primary care setting;prospective;Prospective Studies;Provider;psychiatric comorbidity;public health relevance;Readiness;Recommendation;Records;Reporting;Research;Resources;Risk;Sampling;School-Age Population;screening;Screening procedure;Secure;Sensitivity and Specificity;Signal Transduction;Site;Standardization;Symptoms;Testing;Time;Toddler;tv watching;United States Preventative Services Task Force;validation studies;Visit;web portal;Well Child Visits

PROJECT_TITLE: Sensitivity of toddler screening: Integrating concurrent and prospective strategies to detect ASD

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-R(02)M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: OMAHA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE People living with HIV that develop HIV-associated neurocognitive impairment (HAND) show increased brain amyloid-β (Aβ) production and aggregation, amyloid plaques, increased Tau hyperphosphorylation (pTau) and formation of neurofibrillary tangles-like structures, but the associated mechanisms are not known. This proposal will investigate the role of CCR5 in these pathologies and determine whether following HIV-1 infection, co- administration of antiretroviral drugs with the CCR5 antagonist maraviroc can prevent the formation of amyloid plaques, pTau, and neuroinflammation, abrogate brain vascular injury, neuronal loss and HAND. These novel studies involve mechanistic in vitro, in vivo, and ex vivo approaches and are relevant for designing therapeutic strategies to prevent or reduce Alzheimer’s Disease-like pathologies in HIV-infected individuals.

PI_NAMEs: KANMOGNE, GEORGETTE D. (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Abeta synthesis;Address;Alzheimer like pathology;Alzheimer's Disease;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;amyloid precursor protein processing;amyloidogenesis;Animal Model;antagonist;Anti-Retroviral Agents;antiretroviral therapy;Area;Autopsy;beta-site APP cleaving enzyme 1;Blood - brain barrier anatomy;Brain;Brain Pathology;brain tissue;Catabolism;CCL4 gene;CCR5 gene;Cells;Central Nervous System;central nervous system injury;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Cerebrovascular Trauma;design;Development;Down-Regulation;Endocytosis;Endothelium;Enzymes;epigenome;epigenomics;Functional disorder;Genes;Genetic Transcription;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;HIV/AIDS;Human;humanized mouse;hyperphosphorylated tau;Impaired cognition;Impairment;In Vitro;in vivo;Individual;Induced Neurons;Infection;Injury;Interleukin-6;LDL-Receptor Related Protein 1;Lipoproteins;Macrophage;Mediating;Metabolism;Molecular Profiling;Neprilysin;Nerve Degeneration;Neurocognitive Deficit;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;neuron loss;Neurons;neurotoxic;novel;novel therapeutic intervention;Pathology;Pathway interactions;Peptide Hydrolases;Persons;Pharmaceutical Preparations;Phosphotransferases;Play;prevent;Production;protective effect;RANTES;receptor;receptor expression;receptor for advanced glycation endproducts;Regimen;Research Priority;Role;Senile Plaques;Structure;System;tau Proteins;tau-1;Tenofovir;Testing;Therapeutic;transcriptome;transcriptomics;United States National Institutes of Health;Up-Regulation;uptake;Vascular Endothelium;Viral Load result;Zidovudine

PROJECT_TITLE: PREVENTING ALZHEIMER’S DISEASE-LIKE BRAIN PATHOLOGY IN HIV INFECTION BY TARGETING CCR5

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_DEPT: BIOLOGY

PHR: Project Narrative The ability to learn and form memories is crucial for everyday life. Therefore, it is not surprising that diseases that affect these abilities are devastating and individuals affected are often unable to care for themselves. The fundamental goal of this project is to understand the role of local and long-range interneurons in hippocampal and medial prefrontal cortex oscillations in associative learning.

PI_NAMEs: RAMIREZ-GORDILLO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acute;Address;Advisory Committees;Affect;Animals;Area;Association Learning;awake;Axon;Behavior;Behavioral;Brain;Brain region;Ca(2+)-Calmodulin Dependent Protein Kinase;Calmodulin;calmodulin-dependent protein kinase II;career;career development;Career Mobility;Caring;Cells;Cellular biology;Colorado;Communication;Core Facility;Coupling;Data;Data Analyses;density;Development Plans;Developmental Biology;discrimination task;Disease;Distant;Drug Controls;Electrodes;Ensure;Environment;experimental study;Faculty;Feedback;Frequencies;Fright;Funding;Goals;Hippocampus;improved;Individual;Interneuron function;Interneurons;Knockout Mice;Lead;learned behavior;Learning;Life;Link;Long-Term Depression;Long-Term Potentiation;mature animal;Medial;Mediating;member;Memory;Mentors;Mus;neural circuit;Neurons;Neurosciences;neurotransmission;odor discrimination;Odors;olfactory bulb;Olfactory Learning;optogenetics;Parvalbumins;Performance;Phase;Phosphotransferases;Play;Population;Positioning Attribute;Prefrontal Cortex;Pythons;Research;research and development;Research Personnel;Research Project Grants;Resources;Respiration;Rewards;Role;senior faculty;Sensory;sensory integration;Signal Transduction;skills;Somatostatin;success;symposium;Testing;Training;Training Programs;transmission process;Universities;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Sensory and learning improvements elicited by oscillatory coupling through local and long-range interneurons


NIH_SPENDING_CATS: Genetics

ORG_DEPT: PEDIATRICS

PHR: Project Relevance Transcription factors (TFs) of the TALE family play essential roles in embryonic development, and their dysregulation underlies several types of cancer. We find that closely related family members – that appear to function interchangeably in vitro – actually diverge considerably with respect to their function in vivo. By defining the mechanisms that control this heightened in vivo selectivity, our experiments will provide fundamental information about the activity of these TFs in their native environment, as well as their roles in human disease.

PI_NAMEs: SAGERSTROM, CHARLES G (contact)

PROJECT_TERMS: Address;Affect;Animals;Area;Binding;Binding Proteins;Binding Sites;Biological Process;cancer type;Cell Count;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Compensation;Congenital Abnormality;Data;Data Set;Dimerization;Disease;DNA;DNA Binding;Elements;Embryo;Embryonic Development;Environment;Equilibrium;experimental study;Family;Family member;functional outcomes;gain of function;Gene Expression;Gene Structure;Genes;Genetic Transcription;genome-wide;Genomics;homeodomain;Homeostasis;HOX protein;human disease;In Vitro;in vivo;insight;loss of function;Malignant Neoplasms;Mediating;member;Mutation;novel;Oogenesis;Outcome;Output;permissiveness;Phenotype;Play;Positioning Attribute;preference;Preparation;programs;Property;protein protein interaction;Proteins;Reporting;Repression;Research;Role;Site;System;Testing;transcription factor;Transcriptional Regulation;transcriptome sequencing;tumor progression;tumorigenesis;Work;Zebrafish;zebrafish development

PROJECT_TITLE: In vivo motif selectivity and functionality of TALE family TFs

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Relevance Production of collagen matrix in the heart is critical for proper growth and maturation of this organ, and related pathways are responsible for the accumulation of fibrotic material in the heart of post- MI patients. Cardiac fibrosis contributes to progressive heart disease, and new therapies directed at limiting the fibrotic response are desperately needed, especially end stage heart failure. This application will investigate the interplay between cardiac fibroblasts and myocytes in the heart, and the role that ECM structural support plays.

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Actins;Acute;Adhesions;Adult;beta Actin;beta catenin;Biology;Cardiac;Cardiac Myocytes;cardiogenesis;cell type;Cells;Characteristics;Collagen;Collagen Fibril;Collagen Type I;Communication;Complementary DNA;Complex;coronary fibrosis;crosslink;Data;Defect;density;Disease;Dystroglycan;Extracellular Matrix;F-Actin;Fibroblasts;Fibrosis;Focal Adhesions;Foundations;Future;gamma Actin;Gene Deletion;Gene Modified;Generations;Genetic;genomic locus;Growth;Hand;healing;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Hydrogels;Hypertrophy;Impairment;in vivo;Injury;Integrins;Mediating;Molecular;mouse model;Mus;Muscle Cells;Myocardial Infarction;Myofibroblast;novel;novel therapeutics;Organ;overexpression;paracrine;Pathogenesis;Pathologic;Pathway interactions;Patients;periostin;Play;pressure;Process;Production;Property;protein aggregation;Protein-Lysine 6-Oxidase;Receptors, Adrenergic, beta-1;Reporter;response;Role;Signal Pathway;Signal Transduction;Tamoxifen;Testing;therapeutic target;three dimensional cell culture;tool;Transforming Growth Factor beta Receptors;Transgenic Mice;Ventricular Remodeling

PROJECT_TITLE: Dissecting the role of the cardiac fibroblast in hypertrophy.

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Dysfunction and death of the insulin-producing β cell underlies virtually forms of diabetes, and the regeneration of β cells through growth and replication represents an approach to the treatment of diabetes that has yet to be exploited. Nutrients are key regulators of β cell growth and development, and this proposal will provide a better understanding of how nutrients induce β cell replication. Using novel mouse models, we will interrogate the molecular pathways that mediate nutrient induced β cell replication, with the intent of eventually targeting these pathways in the treatment of diabetes.

PI_NAMEs: ALONSO, LAURA C;MIRMIRA, RAGHAVENDRA G (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Acute;Amino Acids;Anabolism;Arginine;Assessment tool;ATF6 gene;Beta Cell;Biogenic Amines;Biosensor;blood glucose regulation;Cell Cycle;cell growth;Cell Proliferation;Cells;Cellular biology;Cessation of life;Collection;conditional knockout;Data;deoxyhypusine synthase;Dependence;Diabetes Mellitus;Diet;Disease;eIF-5A;Enzymes;experimental study;Functional disorder;functional restoration;Gatekeeping;Genetic;Genetic Transcription;Glucose;Glutamine;Growth;Growth and Development function;Human;Hyperglycemia;hypusine;Image;in vivo;Insulin;islet;Knockout Mice;Leucine;Link;Mediating;Messenger RNA;Metabolic;Methionine;Modeling;Modification;Molecular;mouse model;mRNA Translation;Mus;Natural regeneration;novel;Nutrient;Nutritional;Obesity;obesogenic;Ornithine Decarboxylase;Pathway interactions;Phase;Phenylalanine;Polyamines;Positioning Attribute;Production;Proliferating;Proline;Proteins;Publishing;Reagent;response;Ribosomes;Rodent;Role;Signal Induction;Signal Transduction;small molecule;Spermidine;Stress;Techniques;Technology;Testing;Time;transcription factor;translation factor;Translations;virtual

PROJECT_TITLE: Role of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and Replication

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Many aspects of cell biology and tissue physiology are essentially problems in material science. The physics of soft materials sets the background on which living organisms evolved, and changes in the material properties of cells and tissues are a central feature of normal development, as well as numerous pathophysiological processes including atherosclerosis, fibrotic disease, and some forms of cancer. This MIRA application combines studies of the 3-D networks formed by protein filaments and the 2D surfaces formed by phospholipids to determine how the physical-chemical properties of these structures help determine their biological function.

PI_NAMEs: JANMEY, PAUL A (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Regulation of cell function by mechanical properties of biopolymer networks and lipid bilayers


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Genomic profiling and cytogenetic analysis have characterized AML as highly heterogeneous disease. Targeted therapies have been developed for some prevalent mutations yet their clinical responses are short- lived as resistance develops over time, prompting the rapid shift toward combination. The proposed research builds on the largest AML patient cohort, and seeks to study the interplay between tumor heterogeneity, microenvironment, and ex-vivo combination therapy response, at an individual cell resolution using new integrative machine learning approaches.

PI_NAMEs: NIKOLOVA, OLGA H (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: actionable mutation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;BCL2 gene;bcr-abl Fusion Proteins;Biological Assay;Bone Marrow;cancer therapy;Cell Differentiation process;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chronic Myeloid Leukemia;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combination Drug Therapy;combinatorial;Combined Modality Therapy;Computing Methodologies;CRISPR/Cas technology;Cytogenetic Analysis;Data;Data Set;Disease;driver mutation;Drug Combinations;Drug Controls;drug efficacy;Drug resistance;drug response prediction;Drug Screening;drug sensitivity;Drug Targeting;Face;Genes;Genetic;genetic signature;Genetic Transcription;Genetic Variation;Genome;genome-wide;genomic profiling;Genomics;improved;Individual;individual patient;inhibitor;Joints;Karyotype;leukemia;Link;Machine Learning;machine learning algorithm;Malignant Neoplasms;Mass Spectrum Analysis;MCL1 gene;MEKs;Modality;Modeling;Molecular;molecular drug target;multiple omics;Mutation;Myelogenous;novel strategies;Outcome;patient stratification;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Play;predicting response;predictive modeling;Proteins;Research;Resistance;Resistance development;resistance mechanism;Resolution;Resources;response;Role;Sampling;Shapes;Signal Transduction;targeted agent;targeted treatment;Testing;Therapeutic Intervention;Time;Training;transcriptomics;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Joint differentiation-state plasticity and genetic diversity modeling to predict response and improve efficacy of drug combination therapy