NIH_SPENDING_CATS: Aging;Cancer

PHR: Project Narrative Intrinsically disordered proteins play critical roles in many cellular functions, as well as many diseases including cancer, neurodegenerative disorders, and cardiomyopathies. Research presented at the 2024 Intrinsically Disordered Proteins (IDPs) Gordon Research Conference (GRC) will emphasize molecular mechanisms of intrinsically disordered protein function, as well as understanding how dysregulation of disordered proteins leads to disease. This information exchange at the forefront of knowledge will promote new, interdisciplinary scientific research, collaborations, and training opportunities in this key area for human health.

PI_NAMEs: MITTAG, TANJA  (contact)

PROGRAM_OFFICER_NAME: AMIN, ANOWARUL

PROJECT_TERMS: Address;Aging;Alzheimer's Disease;Amino Acids;Area;Binding;Biochemical;Biocompatible Materials;Biological;Biological Process;biological systems;Biology;Biophysics;cancer cell;Cardiomyopathies;career;Cell Physiology;Cells;Chromosomal translocation;Chronic Myeloid Leukemia;Collaborations;Communicable Diseases;Communities;Dedications;Disease;diversity and inclusion;Environment;Exclusion;Exhibits;Female;flexibility;Frontotemporal Dementia;Functional disorder;Funding;Fusion Oncogene Proteins;Future;Health;Hour;Human;human disease;improved;inhibitor;interest;Knowledge;Lead;lectures;Life;Link;Malignant Neoplasms;meetings;minority scientist;Molecular;Molecular Conformation;Mutate;Mutation;Neurodegenerative Disorders;Nucleolar Proteins;nucleophosmin;Organism;Output;Pathogenesis;Pathologic;Pattern;Pharmaceutical Preparations;pharmacologic;Phase;Physical condensation;Play;Polymers;Post-Translational Protein Processing;Process;programs;Property;protein function;Protein Region;Protein Tyrosine Phosphatase;Proteins;Publishing;Receptor Protein-Tyrosine Kinases;Reporting;Research;Role;Science;Scientist;Shapes;Signal Pathway;single molecule;small molecule;Solubility;Structure;Structure-Activity Relationship;Switzerland;symposium;targeted treatment;Tertiary Protein Structure;Therapeutic;Therapeutic Intervention;therapeutic target;Time;TP53 gene;training opportunity;Travel;Tumor Suppressor Proteins;Underrepresented Minority;Underrepresented Populations;Virus Diseases;Vision;Woman

PROJECT_TITLE: 2024 Intrinsically Disordered Proteins Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 PCRB-9 (J1)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

ORG_CITY: IOWA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE. The proposed research is investigating alterations to Golgi structure and function, essential components of β-cell secretory pathway functioning, following exposure to proinflammatory cytokines produced by immune cells during Type 1 Diabetes pathology. Currently, clinical therapies preventing long-term disease progression are lacking, and the mechanisms of β-cell contribution to disease pathology are unknown. This work will therefore describe how iNOS-mediated pathological NO production contributes to GRASP55- dependent Golgi remodeling, and how this ultimately impacts cell-surface glycosylation and secretory protein sorting and modification, providing critical information and understanding of how altered β-cell presentation may be contributing to disease pathology in early Type 1 Diabetes.

PI_NAMEs: BLOM, SANDRA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affect;Autoimmune;Beta Cell;cell injury;Cell Line;Cell surface;Cells;Chemicals;Clinical;Coupling;cytokine;Data;Defect;Dependence;Disease;Disease Progression;Early Intervention;Enzymes;Event;experimental study;Exposure to;Flow Cytometry;Genetic;glycosylation;Golgi Apparatus;GORASP2 gene;Heat Stress;Human;Huntington Disease;Immune;Impairment;Inflammatory;insight;Insulin-Dependent Diabetes Mellitus;Interferon Type II;Interleukin-1 beta;islet;knock-down;Knock-out;Letters;Measures;Mediating;Mentors;Metabolic;Modeling;Morphology;mutant;neoantigens;Neurons;new therapeutic target;Nitric Oxide;Nitric Oxide Donors;nitrosative stress;Non-Insulin-Dependent Diabetes Mellitus;NOS2A gene;novel;novel therapeutics;Pathologic;Pathology;Pathway interactions;pharmacologic;Post-Translational Protein Processing;prevent;Production;Protein Export Pathway;Protein Glycosylation;Protein Sortings;protein transport;Protein-Folding Disease;Proteins;Quality Control;Regulation;Reporting;Research;Rodent;Role;Secretory Cell;secretory protein;Site-Directed Mutagenesis;Stress;Structural Protein;Structure;Structure of beta Cell of islet;Testing;TNF gene;Up-Regulation;Work

PROJECT_TITLE: GRASP55 Regulates Pancreatic Beta-cell Golgi Structure and Function During Cytokine Stress

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Diabetes Endocrinology and Metabolic Diseases [DDK-E]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: WASHINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE This 2-year F32 proposal will facilitate the successful launch of Dr. LoParco’s independent research career focused on multilevel determinants of substance use among young adults and related inequities. The proposed research uses a Social Determinants of Health lens and novel methods, and focuses on derived psychoactive cannabis products (DPCPs), which are an increasing but understudied public health concern; the specific aims are to examine: 1) cannabis and DPCP marketing characteristics in relation to state cannabis and DPCP related policies; 2) causal associations between cannabis/DPCP state policy, marketing, individual determinants (perceptions, use motives), use, and consequences (via longitudinal cohort data from an ongoing R01); and 3) young adults’ cannabis- and DPCP-specific experiences/perceptions regarding legal and commercial determinants of use (via interviews). Training goals focus on: 1) legal and commercial determinants of health; 2) qualitative/mixed methods research and advanced quantitative analysis; and 3) professional development.

PI_NAMEs: LOPARCO, CASSIDY R (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: Address;Advertising;Age;Agriculture;Automobile Driving;Behavior Therapy;Cannabis;Cannabis policy;Cannabis retail;career;Characteristics;Classification;Cognitive;Complex;Data;Development;Dryness;Ethnic Origin;evidence base;experience;Farm;Foundations;Frequencies;gender minority;Goals;health determinants;Hemp;Illicit Drugs;Imagery;improved;Individual;Industry;Inequity;Intervention;Interview;Knowledge;Laws;Legal;lens;Longitudinal cohort;male;marijuana legalization;marijuana use;Marketing;Mediating;Mediation;Mental Health;Methods;National Institute of Drug Abuse;novel;Outcome;Participant;Perception;Persons;Plants;poison control;Policies;Population;Prevalence;Public Health;Race;Reaction;Recreation;Regulation;Reporting;Research;Research Methodology;Research Personnel;Research Priority;Risk;risk minimization;Safety;sex;sexual minority;skills;social health determinants;social norm;social structure;sociodemographics;Stimulus;structural determinants;Structure;substance use;surveillance data;Tetrahydrocannabinol;Time;Training;Weight;young adult;Youth

PROJECT_TITLE: Socio-structural determinants of cannabis and derived psychoactive cannabis product use and consequences among young adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative: The purpose of membrane depolarization and ionic flux in human cortical histogenesis remains poorly examined. The recent identification by our lab of mutations in the gene encoding the ATP-releasing ion channel Pannexin 1 (PANX1) associated with cases of polymicrogyria (many small brain folds; PMG) provides a window for investigating processes of brain development regulated by electrical coupling. The proposed research aims to functionally investigate these novel PANX1 variants to further both our understanding of the gene’s role in PMG pathogenesis, as well as the impact of early electrical activity on developmental processes such as neural proliferation, migration, and differentiation.

PI_NAMEs: HYLTON, NORMA KIMBERLEA (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Anions;Biophysics;Brain;Calcium;Calcium Oscillations;Calcium Signaling;cell growth;Cell Line;cell motility;Cell Physiology;Cell Proliferation;Cells;Cerebral cortex;cohort;Complex;Cortical Malformation;Coupling;Cryoelectron Microscopy;Data;Development;Developmental Process;Diagnosis;Disease;DNA Sequence Alteration;Electroporation;Epilepsy;exome;exome sequencing;extracellular;Family;Ferrets;fetal;Functional disorder;gain of function;Gap Junctions;Generations;Genes;Genetic;genetic analysis;Glycoproteins;glycosylation;histogenesis;Human;Human Genetics;Image;in utero;In Vitro;in vivo;in vivo Model;Individual;insight;Intellectual functioning disability;Investigation;Ion Channel;Ions;lens;malformation;Membrane;Microgyria;migration;Molecular;Mus;mutant;Mutation;Neocortical Dysplasia;nerve stem cell;neural;Neuroglia;Neuronal Differentiation;Neurons;novel;overexpression;particle;patch clamp;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Pattern;Phenotype;Process;programs;Proliferating;Property;protein function;Proteins;Regulation;Reporting;Research;Role;Shapes;Signal Transduction;stem;Structure;Testing;Therapeutic Intervention;Time;Variant;voltage clamp;Western Blotting;Work

PROJECT_TITLE: Non-Classical Ion Channel Function in Human Cortical Histogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative Negative affect and stress experienced during alcohol abstinence can be a key contributor to relapse in individuals with alcohol use disorder. This proposed research will provide important insight into the neural circuitry underlying the development of negative affective behaviors and stress hypersensitivity during ethanol abstinence. The findings from this research have the potential to identify novel therapeutic targets and inform the development of more effective treatments for individuals with alcohol use disorder.

PI_NAMEs: EDWARDS, CAITLYN MARIE (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;Acute;Affective;alcohol abstinence;alcohol behavior;alcohol response;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Anxiety;Behavior;Behavioral;behavioral response;biological adaptation to stress;Brain;Brain imaging;Brain region;Calcium;Calcium Signaling;cell type;Cells;Chronic;Collection;Confocal Microscopy;Corticotropin-Releasing Hormone;Data;Development;drug of abuse;effective therapy;Ethanol;experience;experimental study;Fiber;Fluorescence Microscopy;Genetic;genetic approach;genetic manipulation;glutamatergic signaling;Glutamates;hindbrain;Hypersensitivity;improved;in vivo;Individual;insight;Lesion;Light;Maps;Modernization;Mus;N-Methyl-D-Aspartate Receptors;negative affect;neural;neural circuit;neurobiological mechanism;Neurons;Neurosciences;Neurosecretory Systems;neurotransmission;new therapeutic target;noradrenergic;Norepinephrine;Nucleus solitarius;opioid withdrawal;Peptide Receptor;Phenotype;Photometry;Play;Population;postsynaptic;prolactin-releasing peptide;rabies viral tracing;receptor;Receptor Signaling;recruit;Relapse;Research;response;Role;Self Administration;Signal Transduction;Source;Stimulus;Stress;Structure of terminal stria nuclei of preoptic region;Synapses;Testing;Viral;Visceral;Withdrawal

PROJECT_TITLE: Role of PrRP+ projections to BNST in ethanol withdrawal and negative affective behavior

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative We seek to understand the interplay between autophagy and senescence malfunctioning as drivers of aging to guide future autophagy therapies to resolve persistent senescence and ameliorate age-related diseases, such as fibrosis and degenerative conditions with unresolved senescence.

PI_NAMEs: SEREDA, REBECCA Z (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Age;age related;age related changes;age related decline;age-related disease;aged;Aging;attenuation;Autophagocytosis;Biochemical;Biology of Aging;career;Cell Aging;Cell Death;cell growth regulation;Cell Physiology;cell type;Cells;Chemicals;Chronic;comparative;Data;Degenerative Disorder;Deterioration;Disease;drivers of aging;Ensure;Excision;Fibrosis;Flow Cytometry;functional loss;functional restoration;Future;Genetic;Goals;Immune;Immune response;Impairment;improved;In Vitro;Inflammation;Interphase Cell;Intervention;Joints;Kinetics;Knock-out;Lysosomes;Macrophage;Malignant Neoplasms;Mediating;Membrane;Mentors;Metabolic dysfunction;Molecular Chaperones;mouse model;Mus;Nature;novel;old mice;Oral;Organ;Organism;Pathway interactions;pharmacologic;Phenocopy;Phenotype;Physiological;Physiological Processes;Play;Polyribosomes;Positioning Attribute;Postdoctoral Fellow;preservation;prevent;Process;Property;Protein Secretion;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Quality Control;receptor;Regulation;Reporter;Research;Resolution;response;Ribosomes;Role;senescence;senescence associated secretory phenotype;senescent cell;skills;small molecule;Stimulus;Stress;System;Testing;Tissues;Training;Translations;Up-Regulation;Work;wound healing;Writing

PROJECT_TITLE: Role of Chaperone-Mediated Autophagy in Cellular Senescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: NEW YORK

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE The Institute for Health Equity Research Catalyst Center will provide scientific training and support to promote community-informed minority health and health disparities research. Catalyst will focus on health equity science methods and approaches; the development of robust, sustainable academic-community partnerships; and the creation of novel dissemination strategies for scientific and non-scientific communities. Through an innovative pilot project program, Catalyst Equity Scholars will be supported with funding, mentoring, and unique research training, and career development activities in collaboration with a network of community partners, providing opportunities for multi-sector learning and partnership with the goal of rapid translation of research to policy and practice.

PI_NAMEs: HANKERSON, SIDNEY H;HOROWITZ, CAROL R;RICHARDSON, LYNNE D. (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Area;Behavioral;behavioral health;career;career development;catalyst;Clinical;Collaborations;Collection;Communities;community academic partnership;community engaged approach;community engaged research;community engagement;Community Networks;community organizations;community partners;Complex;Consultations;Data;Data Analyses;Dedications;design;Development;Discipline;Disparity;disparity elimination;Disparity population;dissemination strategy;Education;Educational workshop;Environmental Health;Equity;Ethnic Origin;Evaluation;experience;Faculty;Food;Funding;gender minority group;Goals;Grant Review;Health;Health Disparities Research;health disparity;health equity;Health equity research;Health Priorities;Healthcare;Homelessness;improved;innovation;Institution;Intervention;Intervention Studies;Journals;Learning;Link;Low income;Malignant Neoplasms;Measurable;Measurement;Measures;medical schools;member;Mentors;Methodology;Methods;minority health;minority health disparity;Mission;National Institute on Minority Health and Health Disparities;Neighborhoods;novel;outreach;Performance;Phase;PhenX Toolkit;Pilot Projects;Policies;Population;population health;Population Heterogeneity;Postdoctoral Fellow;Process;programs;Race;Research;research and development;Research Design;Research Methodology;Research Personnel;Research Training;Resources;Science;Services;Sexual and Gender Minorities;skill acquisition;skills;social;Source;symposium;Training;Training and Education;Training Programs;Translational Research;Translations;United States National Institutes of Health;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 ML (J1)]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: RICHARDSON, LYNNE D. (contact)

PROJECT_TERMS: Address;Advocate;Award;Budgets;Calendar;catalyst;Collaborations;Communication;Communities;community engaged approach;community engagement;community partners;community partnership;Data;Data Sources;design;Development;Discipline;Disparity population;Educational Activities;empowerment;Ensure;Equity;Evaluation;Faculty;Goals;Grant;Health;Health Disparities Research;health disparity;health equity;Health equity research;Healthcare;Human Resources;implementation process;Information Dissemination;Infrastructure;innovation;Institution;Leadership;Link;Logic;long-standing disparities;Measures;medical schools;meetings;Methods;minority health;minority health disparity;Mission;Modeling;Monitor;Names;National Institute on Minority Health and Health Disparities;network models;Outcome;outcome disparities;Patients;Performance;Pilot Projects;Policies;Policy Maker;Postdoctoral Fellow;Process;Productivity;Program Development;Program Evaluation;programs;Publications;Reporting;Research;Research Methodology;Research Personnel;Research Training;Resource Sharing;Resources;Science;Surveys;Training;Training Activity;Translations;web site

PROJECT_TITLE: The Institute for Health Equity Research Catalyst Center


PI_NAMEs: HANKERSON, SIDNEY H (contact)

PROJECT_TERMS: Address;Applications Grants;Appointment;Area;Award;career;career development;catalyst;cohort;Collaborations;Communities;community academic partnership;community center;community collaboration;community engaged research;community engagement;community partners;Complex;Consultations;curriculum enhancement;Data;design;Development;Development Plans;Discipline;Disparity;dissemination strategy;Economically Deprived Population;Education;Educational Curriculum;Educational workshop;empowerment;Ensure;ethnic minority;Evaluation;Extramural Activities;Faculty;Fostering;Funding;Future;Goals;Grant;health determinants;Health Disparities Research;health disparity;health disparity populations;health equity;Health equity research;Health system;Individual;Institution;interest;Journals;Knowledge;Lead;Learning;Manuscripts;Medical;medical schools;meetings;Mentors;Mentorship;Methodology;Methods;minority health;minority health disparity;Modeling;Names;National Institute on Minority Health and Health Disparities;novel;Outcome;Participant;Pilot Projects;Policy Maker;Population;Postdoctoral Fellow;programs;Publications;racial minority;repository;Research;research faculty;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Science;Scientist;Secure;Services;Sexual and Gender Minorities;skill acquisition;skills;socioeconomic disadvantage;Training;Underrepresented Populations;United States National Institutes of Health;Work


PI_NAMEs: HOROWITZ, CAROL R (contact)

PROJECT_TERMS: Address;Adoption;Area;Basic Science;Budgets;career;catalyst;Chronic Disease;Clinical Trials;Collaborations;Communities;community academic partnership;community engaged research;community engagement;community involvement;Community Networks;community organizations;community partners;community partnership;Consultations;Development;Discipline;Disparity;dissemination strategy;Education;Ensure;Environmental Health;Evaluation;Event;experience;Faculty;Focus Groups;Fostering;Funding;Future;Goals;Grant;Health;Health Disparities Research;health equity;Health equity research;health inequalities;Health Priorities;ideation;Individual;interest;Justice;Knowledge;Language;Link;literacy;Machine Learning;Manuscripts;meetings;member;Mental Health;Mentors;Methods;minority health;minority health disparity;Modeling;Neighborhoods;network models;novel;Outcome;Paper;Phase;Pilot Projects;Policies;Population;Productivity;programs;Publications;Rare Diseases;Research;Research Design;Research Personnel;Research Training;Resources;Science;Services;Summary Reports;symposium;tool;Training;Translational Research;translational scientist;virtual;Work


ADMINISTERING_IC: HD

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  The objective of this project is to assess various options when weighing the goals of dorsiflexion assistance and energy recycling in a Decoupled Energy Storage and Return Variable-Stiffness Orthosis (DESR-VSO). Doing so will shed light on how the DESR-VSO can impact the mechanics of foot drop, a condition caused by a variety of disabilities which can lead to falling, gait compensation, and injury. The rigidity of current ankle-foot orthoses (AFOs) limits range of motion, which compromises ankle push-off power, and the DESR-VSO seeks to combat that technological weakness.

PI_NAMEs: BYWATER, EMILY ANN (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Affect;Agreement;Ankle;ankle joint;Articular Range of Motion;Biomechanics;Cerebral Palsy;Clinical;Clinical Trials;Collaborations;combat;Communication;comorbidity;Compensation;control theory;Data;design;Development;Device Designs;Devices;disability;Disabled Persons;Energy Transfer;Environment;equilibration disorder;Equilibrium;Equipment;equity, diversity, and inclusion;Evaluation;evaluation/testing;fabrication;falls;Feedback;foot;Foot-drop;functional mimics;Future;Gait;Gait abnormality;Goals;Heart Diseases;Heel;Hip region structure;human subject;improved;improved mobility;Injury;innovation;insight;kinematics;Kinetics;Lead;mechanical behavior;Mechanics;Mental Depression;Michigan;Mobility decline;Motor;Muscle Weakness;Nature;nerve damage;Neurologic Deficit;normal aging;novel;Obesity;older adult;Orthotic Devices;Outcome;Pathology;Patients;Performance;peroneal nerve;Phase;Prevention;Process;Property;Prosthesis;Recycling;Rehabilitation therapy;Research;Risk;Risk Factors;Robotics;Safety;Self-Help Devices;Shapes;Software Engineering;Specialist;stem;Stroke;Study Subject;success;Technology;Testing;Toes;Torque;Training;transmission process;Universities;volunteer;Walking;Water;Weight;Work

PROJECT_TITLE: Assessing Design Trade-Offs in an Orthosis with Enhanced Functionality and Customizability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Mental Health;Mental Illness;Nutrition;Prevention

ORG_CITY: ORLANDO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE  The current proposal seeks to enhance the training of the applicant through formal and informal training experiences in eating pathology, qualitative analysis, psychometrics, and advanced nested data methodology. The research project seeks to develop a new measure of protective behaviors, derived primarily from non-binge eating individuals, that can be applied in a binge eating sample to reduce the deleterious effects of this behavior. The final set of protective behaviors will take a harm reduction approach and serve as intervention targets for a fairly intractable psychological disorder with significant public health implications.

PI_NAMEs: BURR, EMILY K (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Affect;Aftercare;Alcohol consumption;attributable mortality;Behavior;Behavior assessment;Behavior Control;Behavioral;behavioral response;Binge Eating;Binge eating disorder;career;Cause of Death;Characteristics;Clinical;Clinical Research;cognitive interview;Comprehension;Consumption;cost;craving;Data;Death Rate;Development;Diagnosis;Diagnostic;dieting;Disease;Disease remission;DSM-V;Eating;Eating Behavior;Eating Disorders;eating pathology;Ecological momentary assessment;economic cost;economic impact;Effectiveness;efficacy evaluation;Eligibility Determination;eligible participant;Ensure;Exhibits;experience;Fatty acid glycerol esters;Feedback;Food;food craving;Frequencies;Future;Harm Reduction;health related quality of life;Heart Diseases;Individual;Intervention;Interview;Intoxication;Investigation;Life;Literature;Measures;Medical;Mental disorders;Methodology;Methods;Modality;Morbidity - disease rate;mortality;negative affect;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Participant;Patients;Phase;Population;prevent;protective behavior;protective efficacy;protective factors;Protocols documentation;psychological distress;Psychometrics;Public Health;Qualitative Methods;Questionnaires;Recording of previous events;recruit;Recurrence;Relapse;Reporting;Research;Research Project Grants;response;Risk;Sampling;Statistical Methods;stress management;stressor;Structure;substance use;Substance Use Disorder;sugar;Surveys;Technology;Testing;Time;Training;United States;usability;Variant;Work

PROJECT_TITLE: Applying Harm Reduction to Binge Eating Disorder: An Investigation of Protective Behavioral Strategies Against Uncontrolled Eating

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: HANOVER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Pseudomonas aeruginosa (Pa) and Candida albicans (Ca) commonly co-infect human airways, leading to overall elevated microbial burden and virulence. This project investigates the Pa signaling pathways that sense and respond to Ca, leading to increased virulence. Research into these mechanisms of virulence regulation is essential for understanding the dynamics of polymicrobial infections and developing improved therapies.

PI_NAMEs: CONAWAY, AMY CAROLYN (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TITLE: Cross-fed metabolites modulate Pseudomonas aeruginosa fitness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Genetics;Mental Health;Neurosciences

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Synaptic development in the human brain is strikingly prolonged compared to other mammals, and in humans, this may contribute both to extended periods of learning and increased susceptibility to neurodevelopmental disease. However, the true biological significance and impact of this extended timing on circuit and behavioral maturation is largely unknown. This project will investigate the impact of synaptic developmental timing on the formation of cortical circuits and adult behavior, and this will present a potential novel approach to prevent disease through therapeutic modulation of neurodevelopmental timing.

PI_NAMEs: RECUPERO, ALEKSANDRA  (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Animals;autism spectrum disorder;Behavior;Behavioral;Biological;Birth;Brain;Cells;Collaborations;CRISPR/Cas technology;critical period;Critical Thinking;density;Development;Disease;Dissection;DLG4 gene;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Equilibrium;Excitatory Synapse;Exhibits;experimental study;Gene Duplication;Genes;Genetic;genetic manipulation;Genome;gephyrin;GTPase-Activating Proteins;Heterozygote;hippocampal pyramidal neuron;Homo;Human;Human Genome;Image;improved;in vivo;indexing;Individual;Inhibitory Synapse;insight;Intellectual functioning disability;Knock-in;Learning;Mammals;Measures;Mediating;Molecular;Morphology;Motion;Movement;multisensory;Mus;Mutation;neural;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;novel strategies;patch clamp;Pathologic;Patients;Phenotype;postsynaptic;Predisposition;prevent;Probability;Proteins;Resolution;response;rho GTPase-activating protein;Role;Sensory;sensory integration;Slice;SRGAP2 gene;Synapses;Testing;Therapeutic;two-photon;Visualization

PROJECT_TITLE: Impact of Species-Specific Synaptic Maturation Timing on Cortical Circuit and Behavioral Development


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Neurostimulation is a promising method for treating emotion dysregulation, a symptom that contributes to transdiagnostic psychiatric distress and is associated with insula dysfunction. Given that the neurostimulation efficacy is related to the precision of stimulation at a specific cortical target, understanding the neural mechanisms of emotion dysregulation will lead to improved transdiagnostic brain stimulation interventions. With the goal of optimizing therapeutic neuromodulation, proposed studies will investigate the role of insular network connectivity in transdiagnostic emotion dysregulation and brain stimulation therapy for dysregulation.

PI_NAMEs: GERLUS, NIMESHA  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adult;Affect;Algorithms;Amygdaloid structure;Anatomy;Arousal;Autobiography;automated segmentation;Birth;Brain;career;causal model;Clinical;Clinical Trials;cognitive control;cognitive reappraisal;Communities;comparison group;Complex;Computer software;connectome;Coupling;Data;Development;Diagnostic;Distress;Doctor of Philosophy;Down-Regulation;Economic Burden;emotion dysregulation;emotion regulation;Emotional;Emotions;Equilibrium;Fiber;Foundations;Functional disorder;Functional Magnetic Resonance Imaging;functional MRI scan;Funding;Galvanic Skin Response;Goals;gray matter;Heart Rate;Hyperactivity;improved;indexing;Informal Social Control;Insula of Reil;Intervention;Knowledge;Lateral;Linear Models;Maintenance;Maps;Medial;Memory;Mental disorders;Methods;Modeling;National Institute of Mental Health;negative affect;Network-based;neural circuit;neuroimaging;neuromechanism;neuroregulation;Neurosciences;novel;Outcome;Participant;Patient Self-Report;Persons;Physicians;Physiological;post intervention;Prefrontal Cortex;Process;Psychiatry;Psychopathology;Public Health;recruit;Regulation;repetitive transcranial magnetic stimulation;Risk Factors;Role;Scientific Advances and Accomplishments;Scientist;Severities;Signal Transduction;skills;Stimulus;Symptoms;System;Testing;Therapeutic;therapy development;therapy outcome;tractography;Training;translational neuroscience;Treatment Efficacy;treatment response

PROJECT_TITLE: Insular Connectomic Mechanisms of Emotion Dysregulation and Neuromodulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Driven to overcome the extreme health disparities experienced by Kentucky’s rural (particularly Appalachian), Black, Hispanic, and socioeconomically disadvantaged populations, the University of Kentucky (UK) proudly proposes UK ASCEND (Achieving Success in Community-Engaged research to elimiNate Disparities). UK ASCEND will cultivate health equity and community-engaged research (CER) success among early stage investigators (ESIs) from diverse backgrounds by implementing and evaluating the innovative ASCEND Scholars Program (ASP). Housed in the Center for Health Equity Transformation and leveraging UK’s rich and collaborative community partnerships and institutional strengths, the ASP’s strategically designed, comprehensive CER Training Program leads directly into a CER Pilot Program that will provide the skills development, bi-directional engagement with community stakeholders, and preliminary studies needed to foster research independence and advance health equity.

PI_NAMEs: CONWELL, DARWIN LEWIS;SCHOENBERG, NANCY E. (contact);WILLIAMS, LOVORIA B

PROJECT_TERMS: Address;Appalachian Region;Area;Black race;Cardiovascular Diseases;career development;Career Mobility;clinical center;collaborative environment;Communication;Communities;community advisory board;community engaged research;community engagement;community partnership;community setting;design;Development;Diabetes Mellitus;Disadvantaged;disparity elimination;dissemination strategy;diversity and inclusion;Economically Deprived Population;Environment;Evaluation;experience;Faculty;Fostering;Grant;health disparity;health equity;health equity promotion;Health equity research;health inequalities;Hispanic;innovation;Institution;Intervention;Kentucky;Leadership;Malignant Neoplasms;Mission;Modeling;Motivation;National Institute on Minority Health and Health Disparities;Nervous System Disorder;Obesity;Outcome;pilot test;Policy Maker;Positioning Attribute;Principal Investigator;Productivity;programs;Provider;Reduce health disparities;remediation;Research;Research Personnel;Research Priority;Research Training;Resources;Rural;scaffold;Scholars Program;Science;Scientist;skill acquisition;skills;socioeconomic disadvantage;Specialized Center;Structure;Substance Use Disorder;success;System;Talents;Training;Training Programs;Translating;Translational Research;Universities;Vision


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SCHOENBERG, NANCY E. (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Appalachian Region;Applications Grants;Area;Black race;cancer health disparity;Cardiovascular Diseases;career development;clinical center;Clinical Research;Collaborations;Communication;Communities;community advisory board;community based participatory research;community engaged research;community engagement;community partnership;data sharing;Dedications;Development;Diabetes Mellitus;Disease;disparity elimination;diversity and inclusion;Economically Deprived Population;Ensure;Environment;Equity;Evaluation;experience;Fostering;Foundations;Goals;Health;health disparity;health equity;health equity promotion;Health equity research;health inequalities;Hispanic;Home;improved;Infrastructure;innovation;Institution;Investments;Kentucky;Lead;Leadership;Link;Malignant Neoplasms;Measures;meetings;mindfulness;National Institute on Minority Health and Health Disparities;Nervous System Disorder;novel;Obesity;Occupational activity of managing finances;Outcome;Performance;primary outcome;Principal Investigator;Productivity;programs;Protocols documentation;Research;Research Personnel;Research Priority;Research Training;rural underserved;Scholars Program;Science;skills;socioeconomic disadvantage;Substance Use Disorder;success;Teacher Professional Development;Training;Training Programs;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities

PROJECT_TITLE: UK ASCEND (Achieving Success in Community-Engaged research to elimiNate Disparities)


PI_NAMEs: PEARSON, KEVIN JOSEPH (contact)

PROJECT_TERMS: Address;Affect;Appalachian Region;Applications Grants;Area;Award;Black race;Cardiovascular Diseases;career;career development;Centers of Research Excellence;cohort;college;Communities;community advisory board;community engaged research;community engagement;community partnership;Data;design;Development;Diabetes Mellitus;Disease;disparity elimination;diversity and inclusion;Economically Deprived Population;Educational workshop;Ensure;Environmental Health;Evidence based program;experience;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;health disparity;health equity;health equity promotion;Health equity research;Hispanic;Institution;Kentucky;Leadership;Link;Malignant Neoplasms;Medicine;member;Mentors;Mentorship;Minority Groups;minority health;minority health disparity;model development;Modeling;Nervous System Disorder;Neurologic;Obesity;Outcome;Pathway interactions;peer;peer coaching;Pilot Projects;Postdoctoral Fellow;programs;Publications;Research;Research Personnel;Research Priority;Research Training;Rural;Scholars Program;skill acquisition;skills;skills training;social;Social Network;socioeconomic disadvantage;Substance Use Disorder;success;Training;Training Programs;Translational Research;translational scientist;United States National Institutes of Health;Universities;Work;Writing


PI_NAMEs: WILLIAMS, LOVORIA B (contact)

PROJECT_TERMS: Address;Affect;Appalachian Region;Black race;career development;Catalogs;Collaborations;Communities;community advisory board;Community Developments;community engaged research;community engagement;Community Health Aides;community organizations;community partners;community partnership;Consultations;design;Development;Disease;Disparity;disparity elimination;Doctor of Philosophy;Economically Deprived Population;Ensure;Equity;evidence base;experience;Faculty;Feedback;Fostering;Funding;Goals;Grant;Health;health disparity;health disparity populations;health equity;health equity promotion;Hispanic;Individual;Institution;interest;Kentucky;Leadership;Malignant Neoplasms;member;minority health;minority health disparity;Mission;Modeling;mortality;National Institute on Minority Health and Health Disparities;novel;Outcome;outcome disparities;Pilot Projects;Play;Population Heterogeneity;Process;Productivity;programs;Research;Research Activity;research data dissemination;Research Infrastructure;Research Personnel;Research Project Grants;Resources;Role;Rural;Scholars Program;skill acquisition;socioeconomic disadvantage;success;symposium;System;Training;Training Programs;training project;Translational Research;Translations;Trust;United States National Institutes of Health;Universities;Work;Writing


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative This project will use Escherichia coli to explore new ways that bacteria protect themselves from methylglyoxal (MGO), a toxic compound ubiquitously produced during central metabolism. In bacteria, MGO interacts with and modifies certain proteins, but the bacterial targets and effects of these modifications are not known. There is growing evidence demonstrating the importance of MGO in both host and microbial physiology, therefore understanding how bacteria cope with exposure to this molecule may inform the development of strategies to combat bacterial infections or modulate the human microbiome.

PI_NAMEs: ALEXANDER, SARA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: antiporter;Arginine;Bacteria;Bacterial Infections;Bacterial Physiology;Bacterial Proteins;Behavioral Mechanisms;biological adaptation to stress;cell injury;Cells;Collaborations;combat;coping;Coupled;Cysteine;Cytoplasm;Data;Detoxification Process;Development;Dihydroxyacetone Phosphate;Discipline;Drug Metabolic Detoxication;Educational process of instructing;Educational workshop;Enterobacteriaceae;Enzymes;Escherichia coli;Escherichia coli Proteins;Eukaryota;experimental study;Exposure to;Famines;follow-up;Fostering;Functional disorder;Future;glycation;Heat shock proteins;High Pressure Liquid Chromatography;host microbiome;Human Microbiome;improved;Infection;Inflammation;insight;interest;Knock-out;knockout gene;Laboratories;Life;Lipids;Lysine;Measures;Mediating;Metabolic;Metabolism;Microbial Physiology;microorganism;Modification;mutant;National Research Service Awards;Nature;Nitrogen;novel;Nucleotides;Pathway interactions;Phenotype;Phosphorylation;Phosphotransferases;Play;Poison;Positioning Attribute;Post-Translational Protein Processing;Potassium;prevent;Process;Production;protective pathway;protein aggregation;protein expression;Proteins;Protons;Pyruvaldehyde;Reporting;Research;Resources;response;Role;Scientist;Site-Directed Mutagenesis;skills;Stress;sugar;Sugar Phosphates;symposium;System;tandem mass spectrometry;Testing;Time;Toxic effect;virtual

PROJECT_TITLE: The Role of Post-Translational Modifications in Bacterial Responses to Methylglyoxal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: MADISON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have demonstrated immense promise to regenerate contractile myocardium in the diseased heart, but reproducibly generating pure populations of hPSC- CMs has been difficult to achieve due to significant batch-to-batch and line-to-line variability in differentiation outcome. To resolve this translational barrier, we propose to better understand human cardiac cell specification in vitro through temporal profiling of high and low purity hPSC-CM differentiations using single nucleus RNA and ATAC sequencing at key progenitor states in the differentiation process. Using this knowledge, we expect to understand how low purity hPSC-CM differentiations assume an alternate differentiation trajectory to inform methods to reproducibly generate high purity hPSC-CMs for cell therapy, drug toxicity, and disease modeling applications.

PI_NAMEs: FEENEY, AUSTIN K. (contact)

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Address;Animal Model;Arrhythmia;ATAC-seq;Biology;Biomanufacturing;Biomedical Engineering;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cause of Death;Cell Communication;Cell Line;Cell Nucleus;Cell Separation;Cell Therapy;cell type;Cells;Clinical;clinical translation;combinatorial;Consumption;Data Set;Development;Developmental Biology;differentiation protocol;disease model;Drug toxicity;embryo tissue;epigenetic marker;epigenomics;Ethics;Event;Flow Cytometry;Future;gene regulatory network;Generations;Genetic Markers;Glycolysis;Growth;Heart Diseases;Heart failure;heart function;Heart Injuries;Human;human pluripotent stem cell;Hypoxia;improved;In Vitro;in vivo;insight;Knowledge;Laboratories;Leadership;manufacture;MAP Kinase Gene;Mesoderm;Metabolic;metabolomics;Methods;Modality;Molecular;molecular marker;Monitor;mortality;multiple omics;Mus;Muscle;Myocardial Infarction;Myocardium;Natural regeneration;novel;Outcome;Pathway interactions;Patients;Phase I Clinical Trials;Physicians;pluripotent stem cell differentiation;Population;preclinical study;Prevention;Process;Production;progenitor;Proteomics;Protocols documentation;Regenerative capacity;Reproducibility;Research;revascularization;RNA;Sampling;Scientist;Signal Pathway;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;skills;Specific qualifier value;stem cell differentiation;stem cells;success;symptom management;Testing;Therapeutic;training opportunity;Transcriptional Regulation;transcriptomics;translational barrier;treatment strategy;Troponin T;Universities;Wisconsin;Work

PROJECT_TITLE: Enhancing robustness of human pluripotent stem cell differentiation to cardiomyocytes by uncovering on- and off-target differentiation trajectories via single nucleus multi-omics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurosciences;Pediatric;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: PROJECT NARRATIVE This research project aims to document family language planning and participation in early interventions, and identify health and demographic disparities in access to interventions or vocabulary skills in deaf and hard of hearing children. This study will make use of a new database of all identified deaf and hard of hearing children in California, and – for the first time ever in the United States – recruit a large prospective sample of children who are representative of the full spectrum of language use and communication preferences. The results of this study will provide critical information about how families navigate the landscape of early interventions, and how these interventions relate to language outcomes.

PI_NAMEs: HALL, WYATTE CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 3 year old;5 year old;access disparities;Address;Age;American Sign Language;Assessment tool;Auditory;Birth;California;Child;Child Development;Clinic;clinical application;Cochlear Implants;Collaborations;Communication;Communication Methods;Complex;Country;Data;Databases;deaf;demographic disparity;design;Development;Diagnosis;Disability status;early childhood;Early Intervention;Education;Ensure;Ethnic Origin;Evidence based intervention;experience;Exposure to;Family;family management;Family Planning;follow-up;forging;foster child;Foundations;Gender;Goals;Guidelines;hard of hearing;health disparity;Human Resources;improved;improved outcome;Infrastructure;Instruction;Intervention;Interview;Knowledge;Language;Language Delays;Language Development;language outcome;Learning;life span;Measures;Mentors;Multilingualism;Nature;neurodevelopment;Outcome;Parents;Patient Recruitments;Pattern;Personal Satisfaction;Policy Developments;Population;preference;Process;programs;prospective;Race;recruit;Research;Research Personnel;Research Project Grants;research study;Resources;Risk;Sampling;Sampling Biases;Schools;Science;screening;Series;Services;Sign Language;skills;Spanish;Speech Therapy;Surveys;System;Technology;Test Result;Time;United States;United States National Institutes of Health;Universities;Vocabulary;Work

PROJECT_TITLE: Family language planning and language acquisition among deaf and hard of hearing children

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (47)]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: NARRATIVE The proposed experiments are aimed at understanding how different parts of the brain form in the correct place. Brain formation is sensitive to disruptions by a variety of factors (e.g., environmental toxins, infectious agents, and genetic conditions) that give rise to a range of neurodevelopmental disorders – ranging from motor control problems such as ataxia, to cognitive defects such as autism. The results from our experiments will begin explaining the basis of such disorders and will help inform studies aimed at treating them.

PI_NAMEs: SAGERSTROM, CHARLES G (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Animals;Anterior;Ataxia;autism spectrum disorder;Brain;Cell Nucleus;cell type;Cells;Cerebellum;Cognitive deficits;constriction;Data;Defect;Development;Developmental Biology;developmental disease;Diagnosis;directed differentiation;Disease;dopaminergic neuron;Embryo;Embryonic Development;Epigenetic Process;experimental study;Functional disorder;gastrulation;GBX1 gene;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Diseases;Goals;hindbrain;in vivo;Individual;Infectious Agent;Knowledge;Limb structure;Midbrain structure;Modeling;Molecular;Molecular Profiling;morphogens;motor control;mutant;nerve stem cell;neural;neurodevelopment;Neurodevelopmental Disorder;neuronal replacement;Organ;Play;Population;Positioning Attribute;Primordium;progenitor;programs;Replacement Therapy;Resolution;response;Role;Signal Transduction;stem cell differentiation;Structure;Substantia nigra structure;Testing;Time;tool;Toxic Environmental Substances;vertebrate embryos;Work;Zebrafish

PROJECT_TITLE: Molecular identification of the isthmic organizer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (02)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Project Narrative Simultaneous alcohol and cannabis use (i.e., co-use) is a significant rising concern given its steady increase in prevalence and increased risk for negative consequences (e.g., cognitive impairment and driving under the influence) among young adults. The proposed project will examine the extent that alcohol and cannabis protective behavioral strategies (PBS) are used and associated with alcohol and cannabis use outcomes on co-use occasions using ecological momentary assessment data. Findings will inform PBS interventions for reducing harm associated with co-use, particularly those that may be delivered in-the-moment through mobile devices such as just-in-time adaptive interventions.

PI_NAMEs: TODARO, SABRINA  (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: adaptive intervention;Address;Age;age group;Alcohol consumption;alcohol measurement;Alcohols;Attention;Behavior;Behavioral;Cannabis;Characteristics;Complex;Data;Data Analyses;Development;drinking;driving under influence;Ecological momentary assessment;Environment;Event;Exhibits;experience;Frequencies;Funding;Goals;handheld mobile device;Harm Reduction;Heavy Drinking;high risk;Holidays;Ice;Impaired cognition;improved;Individual;Intervention;Knowledge;Link;Literature;marijuana use;Measures;Methods;Motivation;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;Outcome;Parents;peer;Persons;Population;Prevalence;prevent;programs;Public Health;Reporting;Research;Research Methodology;Risk;Role;secondary analysis;sexual assault;social;Sports;Strategic Planning;substance use;Tilia;Time;Training;United States National Institutes of Health;United States Substance Abuse and Mental Health Services Administration;university student;young adult

PROJECT_TITLE: Protective Behavioral Strategies on Alcohol and Cannabis Co-Use Occasions


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Astrocytic contributions to the pathology of Alzheimer's disease (AD) gain warranted attention. We will investigate ion transporter Na+/H+ Exchanger Isoform 1 (NHE1) as a therapeutic target for astrogliosis in AD pathogenesis using an APP/PS1dE9 AD mouse model. Completing this study will shed light on efficacy of NHE1 blockade on delaying or attenuating AD pathogenesis.

PI_NAMEs: COLLIER, JENELLE MONET (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;abeta deposition;AD transgenic mice;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;Amyloid beta-Protein;Astrocytes;astrogliosis;Attention;Attenuated;Autopsy;Brain;Brain Diseases;Brain Injuries;Brain region;brain tissue;career development;Cell Count;Cell Volumes;Cognitive;Cognitive deficits;comorbidity;comparison control;Crossbreeding;density;Deposition;Development;Disease Progression;efficacy testing;environmental enrichment for laboratory animals;excitotoxicity;Experimental Models;Flow Cytometry;Functional disorder;Genetic;Genetic Transcription;Glial Fibrillary Acidic Protein;Glutamates;Hippocampus;Histology;Human;Immunohistochemistry;Impaired cognition;Impairment;improved;Inflammatory;inhibitor;innovation;Ions;Ischemic Stroke;knockout gene;Knockout Mice;Learning;Measures;Memory;Messenger RNA;Methods;Modeling;Morphology;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroinflammation;neuroprotection;osmotic minipump;Outcome;Pathogenesis;Pathologic;Pathology;pH Homeostasis;Phagocytes;pharmacologic;Physiological;Pilot Projects;prevent;protein activation;protein expression;Protein Inhibition;Protein Isoforms;Proteins;Protons;Regulation;Reporting;Research;Research Activity;reuptake;Role;Saline;Severities;Specimen;stroke model;Synapses;Synaptic plasticity;tau aggregation;Testing;therapeutic target;Time;Training;transcriptome;Transgenic Mice;Transgenic Organisms;Universities;Up-Regulation;uptake;Vascular Dementia;Wild Type Mouse

PROJECT_TITLE: Astrocytic Na/H exchanger in AD astrogliosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-K (20)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: DAVIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE: Our overarching goal is to develop a transformative integrative experimentally informed digital twin technology for patient-specific prediction. Digital twins across the scales from the atom to the rhythm will allow incorporation of individual differences in genes that affect individual protein structure, cellular electrophysiology and electrocardiograms to predict individual likelihood and mechanisms of disease and to predict individualized therapeutic intervention.

PI_NAMEs: CLANCY, COLLEEN E (contact);SANTANA, LUIS F;VOROBYOV, IGOR

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Adult;Affect;Affinity;Arrhythmia;Artificial Intelligence;atomic data;Behavior;Benign;Binding;Biological Process;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;Cell Extracts;Cell model;Cells;Characteristics;Chemistry;Clinical;Collection;cost;Coupling;Data;Data Set;deep learning;deep learning model;design;Development;digital;digital applications;digital twin;Disease;Disease Progression;DNA Sequence Alteration;Dose;drug efficacy;Drug Interactions;Drug Screening;Drug Targeting;Drug toxicity;Electrocardiogram;Electrophysiology (science);Event;Fingerprint;flexibility;Future;Genes;Genetic;Genetic Diseases;genetic predictors;Genetic Variation;Genotype;Goals;Growth;Heart;Heart Diseases;heart rhythm;Human;improved;in silico;Individual;Individual Differences;individual response;induced pluripotent stem cell derived cardiomyocytes;innovation;insight;Ion Channel;Ion Channel Protein;kinetic model;Kinetics;learning network;Link;Machine Learning;Measurement;Methods;Modeling;models and simulation;Modification;Morphology;multi-scale modeling;novel strategies;Output;Patients;personalized diagnostics;personalized medicine;personalized predictions;Persons;Pharmaceutical Preparations;Pharmacology;Phenotype;Physiological;Physiological Processes;Play;Process;protein function;protein structure;Proteins;Protocols documentation;Regimen;Regulation;response;Risk;Role;Ryanodine Receptor Calcium Release Channel;Safety;screening;Severity of illness;Signal Transduction;simulation;Sorting;stem cells;Structural Models;Structure;System;Systems Integration;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Training;trait;Translating;Twin Multiple Birth;Validation;Variant;variant of unknown significance;virtual;virtual model

PROJECT_TITLE: Digital Twins from the Atom to the Rhythm

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE - OVERALL Uterine fibroids are a major public health issue for all individuals with a uterus and a disease with profound disparities for Black/African American individuals with fibroids. COEQUaL, the COllaboration for EQuity in Uterine Leiomyomas, builds on longstanding collaborations among individuals with uterine fibroids and multidisciplinary researchers at Mayo Clinic, the Fibroid Foundation, University of Mississippi Medical Center and University of Florida-Jacksonville to use behavioral and social science research to identify affected individuals earlier, understand and better meet their needs, delineate internal and external barriers to care, optimize communication between affected individuals and health care providers, and use innovative tools to eliminate barriers to individualized care. The overarching goal of COEQUaL is to improve outcomes for all individuals with uterine fibroids and eliminate health disparities for Black/African American individuals with uterine fibroids. 1

PI_NAMEs: STEWART, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Adoption;Advocacy;advocacy organizations;Affect;African American;African American population;African American Women;age group;Agreement;Anemia;Articulation;Awareness;barrier to care;behavioral and social science;Behavioral Sciences;Black race;cardiometabolism;Caring;Clinic;Clinical;clinical care;Collaborations;college;Communication;community partnership;Conceptions;Data;Decision Making;design;Disease;disparities in women;Disparity;disparity elimination;disparity reduction;Early Intervention;Education;Education and Outreach;Electronic Health Record;empowerment;Equity;Ethics;evidence base;experience;Fibroid Tumor;Florida;Foundations;Functional disorder;Goals;Gonadotropin Hormone Releasing Hormone;Health Disparities Research;health disparity;health equity;Health Personnel;Healthcare Systems;Hemorrhage;Hormone Antagonists;Hysterectomy;improved;improved outcome;Individual;innovation;Insurance;Insurance Carriers;International;Internships;Intervention;Logistics;Medicaid;Medical center;Medicine;Mentors;Mississippi;Modality;Modeling;Modernization;mortality;multidisciplinary;Myometrial;National Institute on Minority Health and Health Disparities;Neoplasms;Newsletter;next generation;Operative Surgical Procedures;Oral;Outcome;Ovary;Pain;Patient advocacy;Patients;personalized care;Pilot Projects;podcast;Policies;pressure;Process;programs;Provider;psychologic;Public Health;racial diversity;reproductive;Research;Research Personnel;risk prediction model;Science;social science research;Source;Specialized Center;Students;success;Symptoms;synergism;Technology;Therapeutic;tool;Training;Universities;Uterine Fibroids;Uterine myomectomy;Uterus;Woman;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZHD1 DSR-B (50)]


NIH_SPENDING_CATS: Contraception/Reproduction;Eye Disease and Disorders of Vision;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: Advisory Committees;Advocate;African American Women;Award;Black race;Caring;Chronic progressive external ophthalmoplegia;Clinic;Collaborations;Communication;Communities;community partnership;Education;Equity;experience;Fibroid Tumor;Fostering;Funding;Future;General Population;Goals;health disparity;Human Resources;improved;improved outcome;Individual;Infrastructure;Institution;Literature;Mentors;multidisciplinary;next generation;Outcome;outreach;Patients;peer coaching;Pilot Projects;programs;Publishing;recruit;Research;Research Personnel;Resources;Science;Staff Development;success;synergism;Training;Travel;United States National Institutes of Health;Uterine Fibroids;Woman;Women's Health;Work

PROJECT_TITLE: Supporting COEQUal projects and personnel: Administrative CORE


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Dissemination and Implementation Research;Fibroid Tumors (Uterine);Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: ALLYSE, MEGAN A. (contact)

PROJECT_TERMS: Adolescent and Young Adult;Advertising;Affect;African American;African American Women;Age;analog;Anemia;Area;Awareness;behavioral and social science;Black race;black women;burden of illness;care seeking;Caring;Clinic;Clinical;Collaborations;Communication;Communities;community based research;community engaged research;contextual factors;County;Data;design;Diagnosis;digital;digital health;early awareness;Early Diagnosis;early onset;Early treatment;Education;Equity;Evaluation;Event;experience;Family;Family member;fertility preservation;Fibroid Tumor;Florida;Focus Groups;girls;Goals;Gynecology;Health;health related quality of life;Health system;Hemorrhage;High Prevalence;high risk;Hysterectomy;implementation efforts;implementation framework;improved;Incidence;Individual;Information Dissemination;Insurance Coverage;Intervention;Knowledge;Medical Care Team;Medical center;Menstruation;Methods;Mississippi;Multicultural Education;Muscle Cramp;Newsletter;Not Hispanic or Latino;Pain;Patient Care;patient engagement;Pelvis;Penetration;Performance;Population;Provider;Quality of life;Recommendation;Reporting;reproductive;Research Methodology;Research Personnel;Resources;routine care;Self Care;Self Efficacy;Signs and Symptoms;social media;social science research;Source;Subgroup;success;Symptoms;Taboo;tool;Treatment outcome;ultrasound;Universities;Uterine Fibroids;White Women;Woman;Women's study;Work

PROJECT_TITLE: Targeted Awareness and Education on Options in Uterine Fibroids


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: BORAH, BIJAN  (contact)

PROJECT_TERMS: access disparities;Adoption;African American;African American Women;Area;Articulation;Black race;Caring;Characteristics;Clinical;Collaborations;Combined Modality Therapy;copayment;Data;Decision Making;Diagnosis;Discipline of obstetrics;Disparity;disparity reduction;distrust;Educational Status;Empirical Research;empowerment;Equity;evidence base;Evidence based treatment;experimental study;Family Practice;Fibroid Tumor;Focus Groups;Future;Goals;Gonadotropin Releasing Hormone Inhibitor;Gynecologic;Gynecologist;Gynecology;health assessment;health care quality;Health Care Sector;health care service organization;Health Disparities Research;Health Insurance;Health Personnel;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;Hysterectomy;Infrastructure;insight;Insurance;Insurance Coverage;Internal Medicine;Knowledge;Link;Literature;Measures;Medicaid;Medical;medical specialties;National Institute on Minority Health and Health Disparities;novel;Nurse Practitioners;optimal treatments;Oral;Organizational Change;Outcome;Patients;Pediatrics;Physician Assistants;Physicians;Pilot Projects;Policies;Policy Developments;Population;post-COVID-19;preference;Procedures;Provider;racial difference;Recommendation;Reporting;Research;Research Personnel;Safety;Secondary to;shared decision making;social health determinants;standard care;structural health determinants;Symptoms;Training;treatment and outcome;Uterine Fibroids;Uterine myomectomy;Uterus;White Women;Woman;women's treatment

PROJECT_TITLE: Articulating External Factors that Limit UF Outcomes for All Women and Create Disparities for BAA women


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: LAUGHLIN-TOMMASO, SHANNON KATHLEEN (contact)

PROJECT_TERMS: Address;African American Women;Age;Artificial Intelligence;Attention;Awareness;behavioral and social science;biobank;Black American;Black race;care delivery;Caring;Characteristics;Clinical;clinical care;Clinical Data;clinical decision support;clinical risk;Collaborations;Communities;community advisory board;community clinic;Community Hospitals;Country;Data;Decision Making;Diagnosis;Disease;Disparity;Early Diagnosis;Early identification;Early Intervention;early onset;electronic health data;Electronic Health Record;electronic health record system;empowerment;Ensure;Equity;Ethics;ethnic diversity;Evaluation;evidence base;experience;Exposure to;Fibroid Tumor;Foundations;Genetic;genetic information;genetic variant;Geography;Goals;Health;health care disparity;health care service utilization;Health Personnel;Health Status;Healthcare;Healthcare Systems;Heritability;High Risk Woman;Hysterectomy;Image;improved;Individual;individualized medicine;Inequity;innovation;innovative technologies;Intervention;Link;Machine Learning;marginalization;Medical;medical specialties;Medicine;member;minimally invasive;Modeling;Operative Surgical Procedures;Outcome;Ovarian;patient advocacy group;Patient Care;patient oriented;Patients;Perception;Performance;Play;polygenic risk score;poor health outcome;Population;portability;Positioning Attribute;preservation;Prevention;Process;Provider;racial diversity;Research;Research Methodology;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;Rural;screening;shared decision making;Site;social science research;Standardization;support tools;Symptoms;System;Technology;Therapeutic;tool;Translating;treatment guidelines;treatment optimization;Uterine Fibroids;Uterus;Variant;Woman;Women's Health;Work

PROJECT_TITLE: Developing Innovative Tools To Overcome Factors that Limit Outcomes for All Women and Disparities for BAA women


NIH_SPENDING_CATS: Contraception/Reproduction;Fibroid Tumors (Uterine);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: VENABLE, SATERIA  (contact)

PROJECT_TERMS: Advocacy;advocacy organizations;Affect;African American population;African American Women;Articulation;Black race;Caring;Clinical;clinical practice;Collaborations;Communities;Community Health Education;community partnership;Conceptions;design;disparities in women;disparity elimination;disparity gap;Education;Education and Outreach;Educational Materials;Elements;Equity;Ethics;Evolution;Family;Feedback;fertility preservation;Fibroid Tumor;Focused Ultrasound;Foundations;Future;Goals;Gonadotropin Hormone Releasing Hormone;Growth;Gynecologic;health disparity;Health Insurance;Health Personnel;Healthcare Systems;Hormone Antagonists;Hysterectomy;improved;improved outcome;Individual;innovation;Internships;Leadership;Leiomyoma;life span;Magnetic Resonance;member;Mentors;Modality;Modeling;next generation;novel therapeutics;Oral;outreach;Patients;personalized care;podcast;Policies;Positioning Attribute;Preparation;programs;psychologic;Radiofrequency Interstitial Ablation;Research;Research Design;Research Personnel;Source;Specialized Center;Students;success;synergism;Training;Uterine Fibroids;Uterine myomectomy;Uterus;Voice;Woman;Women's study;Work

PROJECT_TITLE: Community Partnership, Education, and Outreach Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: NARRATIVE Opioids pose a serious risk to skeletal health by compounding bone loss in patients requiring pain management, such as those with osteoporosis, as well as predispose opioid users to fracture. Preclinical studies addressing potential causes of reduced bone quality are lacking, and this will be the first proposal to delineate the role of sensory neuron-osteoblast communication via noncoding microRNAs on opioid-induced bone loss. Results will provide basic insights on the regulation of bone formation by micro RNAs that may inform clinical strategies to treat skeletal pain and monitor patients on opioids.

PI_NAMEs: LANGLAIS, AUDRIE  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: addiction;Address;Affect;Afferent Neurons;Award;Biogenesis;Biological Assay;bone;bone cell;Bone Density;bone health;bone loss;Bone Marrow;bone quality;Bone remodeling;bone turnover;Brain;Cell Communication;cell type;Cells;circulating microRNA;Clinical;Communication;cortical bone;Coupled;Data;differential expression;Down-Regulation;Engineering;Female;Femur;Foundations;Fracture;fracture risk;Future;Gene Expression;Gene Targeting;Genes;Genetic Transcription;Goals;Health;Homeostasis;Human;Hypogonadism;Impairment;In Situ;In Vitro;in vivo;insight;knock-down;male;Measures;Mediating;Mediator;Mentors;MicroRNAs;mineralization;Modeling;Morphine;mu opioid receptors;Mus;Musculoskeletal;Musculoskeletal Pain;nerve supply;Nervous System;neural;neuromechanism;Neurons;novel;Ontology;Opiate Addiction;opiate tolerance;Opioid;Opioid agonist;Opioid Analgesics;opioid epidemic;Opioid Receptor;opioid use;opioid user;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteoporosis;Osteosarcoma;Outcome;Overdose;overexpression;Pain;Pain management;Pathway interactions;Patient Monitoring;Patients;Pharmaceutical Preparations;Postdoctoral Fellow;Postmenopause;preclinical study;Prevention strategy;Production;Proteins;receptor expression;Regulation;Research Personnel;Risk;Role;Sensory;Serum;skeletal;Source;Spinal Ganglia;Stains;substantia spongiosa;success;Testing;Tissues;Training;transcriptome sequencing;treatment strategy;United States;Untranslated RNA;Validation;Woman;Work

PROJECT_TITLE: Investigating miRNA-Mediated Bone Loss from Morphine Treatment


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE: Attention importantly constrains vision, filtering sensory information so the brain only receives what it needs to act. But its mechanisms have been enigmatic since its formalization by William James (1890). My project will be the first to rigorously test the validity of the pervading hypothesis that release of the neuromodulator acetylcholine supports attention. Results from this will deepen our understanding of the core principles governing vision, cortical information encoding and representation, and neurological diseases in which attention is disrupted (e.g., schizophrenia, dementia), where interventions affecting cholinergic signaling have had variable results.

PI_NAMEs: AMODEO, JOHN MICHAEL (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Acetylcholine;Affect;Animals;area V4;Arousal;Attention;attentional control;attentional modulation;behavior measurement;Brain;cholinergic;Concentration measurement;Cues;Custom;Dementia;design;Detection;Electrochemistry;Electrodes;Electrophysiology (science);Elements;expectation;Future;innovation;Intervention;Location;Macaca;Maps;Measures;Mediating;Modeling;Monkeys;Nervous System Disorder;neurochemistry;neuromechanism;Neuromodulator;Neurons;neurophysiology;new technology;orientation selectivity;Physiological;Physiology;Play;Positioning Attribute;Primates;rate of change;receptive field;Reporting;Rewards;Role;role model;Rotation;sample fixation;Schizophrenia;Sensory;Signal Transduction;spatial relationship;Specificity;Stimulus;Surface;System;Task Performances;temporal measurement;Testing;Vision;Visual;Visual attention;Visual Cortex;Visuospatial

PROJECT_TITLE: Assessing the spatial and temporal scales of attention effects and attention-dependent cholinergic release in macque V4.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Contraception/Reproduction;Digestive Diseases;Genetics;Human Genome;Maternal Health;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Undernutrition remains a pressing global health problem and the associated poor long-term outcomes are transmitted from mother to child, perpetuating the cycle of poverty. Environmental enteric dysfunction (EED) is a small intestinal inflammatory enteropathy that has been postulated to mediate intergenerational pathogenesis of undernutrition in utero; yet, how maternal EED transmission affects fetal development is not understood. The goal of this proposal is to investigate the hypothesis that the small intestinal microbiota from EED affected mothers contributes to delayed fetal development via aberrant placental vascular remodeling by integrating gnotobiotic mouse models and multi-omic technologies to identify mechanism of intergenerational EED transmission and ultimately develop therapies targeted towards maternal and child undernutrition.

PI_NAMEs: COSKUN, REYAN  (contact)

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Adult women;Affect;Age;aged;angiogenesis;Area;arterial remodeling;Arteries;aspirate;Bacteria;Bangladeshi;Bioinformatics;Biopsy;Birth;Blood flow;Blood Vessels;Body mass index;Brain;Cell Lineage;Cell Physiology;Cellular biology;Characteristics;Child;Child Malnutrition;Childhood;Chronic;computational suite;computerized tools;Data Set;Decidua;Decidual Cell;Decidual Cell Reactions;Defect;Development;Dietary Intervention;DNA;Duodenum;Electric Capacitance;Embryo;Endoscopy;Enteral;Epithelium;Esophagogastroduodenoscopy;experimental study;Feces;Female;Female of child bearing age;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetal Reduction;Fetus;Flow Cytometry;Fluorescence-Activated Cell Sorting;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;Germ-Free;global health;Gnotobiotic;Goals;Growth;gut inflammation;gut microbiota;Histologic;Histopathology;Human;Immune;Immune response;Immunologics;Impairment;improved;in utero;Inflammation;Inflammatory;insight;Interferon Type II;intergenerational;Intestinal Content;intestinal villi;Intestines;Knowledge;Laboratories;Lead;Link;Low Birth Weight Infant;Malnutrition;maternal microbiota;maternal weight;Maternal-Fetal Exchange;Mediating;Mediator;member;Metabolic;metabolic profile;Methods;microbial community;microbiota;Modeling;Mothers;mouse model;Mucous Membrane;multiple omics;multiplex assay;Mus;Natural Killer Cells;neurodevelopment;novel therapeutics;Nuclear RNA;Nutrient;Nutrient availability;Nutritional status;offspring;Outcome;Pathogenesis;Placenta;Placentation;Population;Positioning Attribute;postnatal;postnatal development;Poverty;pre-clinical;Pregnancy;Pregnancy Trimesters;pregnant;prenatal;pup;recruit;repaired;reproductive;Resistance;Resolution;Risk;Role;Second Pregnancy Trimester;Serum Proteins;Shotgun Sequencing;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Slum;Small Intestines;Spiral Artery of the Endometrium;Structure;systemic inflammatory response;targeted treatment;Technology;Testing;Therapeutic;therapy development;Third Pregnancy Trimester;Tissues;transcriptome sequencing;transmission process;treatment group;Uterus;Vascular remodeling;Vertical Disease Transmission;Woman;Women's Health

PROJECT_TITLE: Modeling the effects of the gut microbiota of undernourished mothers with environmental enteric dysfunction on vascular remodeling at the fetal-placental interface

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F06-L (20)]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Regenerative Medicine

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: The elevation of CO2 in blood and tissues (hypercapnia), which is independently associated with ICU mortality, is often an inevitable clinical consequence of mechanical ventilation strategies used to reduce the severity of ventilator induced lung injury in patients with the acute respiratory distress syndrome (ARDS). We propose to investigate whether hypercapnia by inhibiting the tricarboxylic acid (TCA) cycle and activating the integrated stress response (ISR) increases alveolar epithelial permeability by stalling differentiation of alveolar epithelial type 2 (AT2) into AT1 cells. Mitigating the effects of hypercapnia by small molecules may improve recovery after lung injury and thus patients with ARDS.

PI_NAMEs: CHANDEL, NAVDEEP S;SZNAJDER, JACOB I (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute Lung Injury;Acute Respiratory Distress Syndrome;adverse outcome;Air;Alveolar;alveolar epithelium;Animal Model;biological adaptation to stress;Blood;Blood capillaries;Capillary Permeability;Carbon Dioxide;Cell Differentiation process;Cell model;Cell Proliferation;Cells;Citric Acid Cycle;Clinical;Data;Down-Regulation;Edema;Electron Transport;Endothelium;Enzymes;Epithelial Cells;epithelial repair;Epithelium;experimental study;Exposure to;Functional disorder;Gases;Genetic;Genetic Screening;Homeostasis;Human;human RNA sequencing;human tissue;Hypercapnia;Hypoventilation;Impairment;improved;influenza A pneumonia;Influenza A virus;Injury;Isocitrate Dehydrogenase;Link;Liquid substance;Lung;Lung Compliance;Lung Diseases;lung injury;lung repair;Mechanical ventilation;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;mortality;mouse model;Mus;Natural regeneration;Organoids;Outcome;Pathologic;Pathway interactions;Patients;Permeability;Pneumonectomy;pre-clinical;Predisposition;prevent;Publishing;pulmonary function;Recovery;Regulation;repaired;Reporting;response;self-renewal;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Slice;small molecule;Technology;Testing;Tidal Volume;Tissues;transcriptomics;Up-Regulation;ventilation;Ventilator-induced lung injury

PROJECT_TITLE: Mitochondrial maladaptive response of the lung epithelium to elevated CO2 levels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (03)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Genetics;Heart Disease;Human Genome;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Hypoplastic left heart syndrome is a severe type of congenital heart defects with poorly understood origins, partly due to the lack of accessible biological models that can imitate key features of the disease. This proposal aims to address these needs by developing a useful 3D bioprinted platform with disease-specific cells and applying it as a laboratory model to better understand the progression of hypoplastic left heart syndrome in humans. Information gathered from this study will, therefore, advance our overall comprehension of abnormal cardiac development which could lead to new targets for preventative and therapeutic strategies.

PI_NAMEs: ALONZO, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: 3-Dimensional;Address;Anatomy;Animals;Aorta;Architecture;ascending aorta;Biocompatible Materials;Biological Assay;Biological Models;biological systems;Biomechanics;bioprinting;Blood Circulation;Blood flow;Cardiac;Cardiac Myocytes;cardiogenesis;Cardiovascular system;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cells;Characteristics;Clinical;clinical phenotype;Complex;Comprehension;Congenital Heart Defects;Cues;Deformity;Deposition;design;Development;developmental disease;Dimensions;Disease;Electrophysiology (science);Embryo;Endocardial Fibroelastosis;Endocardium;Endothelial Cells;Engineering;Environmental Risk Factor;Ethics;Etiology;Experimental Models;extracellular;Extracellular Matrix;Family member;Gender;gene environment interaction;Genetic;genetic information;Genetic Transcription;Genome;Genomics;Growth;Heart;Heart Abnormalities;heart defect;hemodynamics;Hereditary Disease;Human;human induced pluripotent stem cells;human model;hydrogel scaffold;Hydrogels;Hypoplastic Left Heart Syndrome;Immunofluorescence Immunologic;improved;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;Infant;information gathering;insight;Laboratories;Left;Left ventricular structure;Light;Link;Liquid substance;Mitochondria;Mitral Valve;Modeling;Morbidity - disease rate;Mutate;Mutation;Myocardial;Nature;NOTCH1 gene;novel;Organ;Organogenesis;palliative;Pathogenesis;Patients;Pattern;Procedures;Prognosis;programs;Proliferating;Property;Quality of life;Respiration;response;RNA;Role;Scientist;sensor;shear stress;Side;Signal Transduction;single-cell RNA sequencing;Small RNA;Stains;Stress;Structural defect;Structure;Syndrome;System;Techniques;Technology;Testing;Therapeutic;three dimensional cell culture;three-dimensional modeling;Tissue Engineering;Tissues;tool;transcriptomics;Tube;Ventricular

PROJECT_TITLE: A Dynamic and Three-Dimensional Human Model of Hypoplastic Left Heart Syndrome to Probe Compromised Cardiomyocyte Proliferation


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Preschoolers (3-4-yr-olds) experience accelerated weight gain (ie, increased zBMI) during the summer and lose weight (ie, decreased zBMI) during the school year. We don’t know the places preschoolers go, who they are with, and what they do during the summer that influences their health behaviors and weight status. This project will open new opportunities in obesity prevention by establishing the need to focus on preventing excessive summer weight gain among preschoolers.

PI_NAMEs: BEETS, MICHAEL W (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Acceleration;Accelerometer;Address;Age;Anthropometry;Automobile Driving;Behavior;Calendar;Caring;Child;Child Care;cohort;Communities;Data;Data Set;Development;diaries;Diet;Eating;effective intervention;elementary school;Enrollment;excessive weight gain;executive function;experience;Family;first grade;Fostering;Health behavior;Home;Household;Individual;Informal Social Control;innovation;Interview;kindergarten;Low income;Measures;Mediator;Medicaid eligibility;Methodology;Motor Skills;Neighborhoods;Nursery Schools;Obesity;obesity prevention;Outcome;Overweight;Parents;Physical activity;Play;Poverty;prevent;Prevention;primary outcome;Research;Risk;Sampling;Schedule;School-Age Population;Schools;secondary outcome;Sleep;social;Target Populations;Time;Weight;Weight Gain

PROJECT_TITLE: Contextual Determinants of Accelerated Weight Gain During Summer Among Preschoolers from Low-income Households

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Genetics;Wound Healing and Care

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: PROJECT NARRATIVE Myofibroblasts generate scar tissue in wound healing, but their deactivation and signaling mechanisms after wound healing have yet to be addressed. These studies will characterize the myofibroblast life cycle in the skin and explore the role of Hippo-YAP/TAZ signaling in myofibroblast deactivation. Understanding the mechanisms of myofibroblast fate can lead to new therapeutics to control myofibroblast persistence in wound healing and, more broadly, in fibrotic diseases and cancer stroma.

PI_NAMEs: JEONG, SUNHYE  (contact)

PROJECT_TERMS: Address;Apoptosis;ATAC-seq;Cell Lineage;Cell Nucleus;Cells;Chromatin;Chronic;Cicatrix;Clinical;cofactor;Data;data integration;Data Set;Disease;experimental study;Fibroblasts;Fibrosis;Gene Expression;Genetic;genetic approach;Genetic Transcription;healing;Health;Heterogeneity;Human;Hyperactivity;Hypertrophic Cicatrix;in vivo;inducible Cre;inhibitor;Keloid;Label;Life Cycle Stages;Malignant Neoplasms;Maps;Memory;Messenger RNA;migration;Modeling;Modernization;Modification;Molecular;mouse genetics;mouse model;Mus;Myofibroblast;non-healing wounds;novel therapeutics;Organ;Pathway interactions;periostin;Phenotype;Probability;Process;Proliferating;Regenerative Medicine;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;Skin;skin fibrosis;Skin injury;Skin wound healing;System;Tamoxifen;Techniques;Testing;Tissues;tool;transcription factor;transcriptome sequencing;Translating;upstream kinase;wound;wound closure;wound healing

PROJECT_TITLE: Deciphering the myofibroblast life cycle in skin wound healing


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Rockville

ORG_NAME: FEDERATION OF AMER SOC FOR EXPER BIOLOGY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Subcellular localization of RNAs and mechanisms that ensure on-site protein synthesis play a crucial role in neurons and glia, contributing to morphogenesis, axon guidance, and synapse growth and plasticity and their deregulation has been causally linked to numerous neurodevelopmental and neurodegenerative diseases. The goal of this proposal is to provide support for early-career investigators and trainees, with an emphasis on underrepresented communities, to attend the 2024 FASEB Science Research Conference on RNA Localization and Local Translation. The meeting will promote and advance research in the field, facilitate collaborations, and provide training and career development for junior scientists.

PI_NAMEs: GAVIS, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;age-related disease;Area;Award;axon guidance;axonal pathfinding;Biological Models;Biology;Biophysics;career;career development;Cells;Cellular biology;cellular development;childcare allowance;clinically relevant;Collaborations;Communities;Cytoplasmic Granules;Dedications;Defect;Development;Developmental Biology;Developmental Process;Disease;Educational workshop;Embryo;Ensure;Event;experience;Fostering;Funding;Future;Gel;Gene Expression Regulation;Generations;genome-wide;Genus Mentha;Goals;Growth;Health;Human;Image;improved;Individual;innovation;interest;International;Link;Liquid substance;Mediating;meetings;member;messenger ribonucleoprotein;Messenger RNA;Methods;Modeling;Molecular;Molecular Biology;Morphogenesis;mRNA Translation;multidisciplinary;Nature;Neurobiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neurologic;Neurons;new technology;novel;novel strategies;Oral;Organelles;Organism;Pattern;Physical condensation;physical property;Play;Postdoctoral Fellow;posters;Prevalence;Production;programs;Property;Protein Biosynthesis;protein expression;protein function;Proteins;Regulation;Research;Research Personnel;RNA;RNA metabolism;RNA Transport;RNA-Binding Proteins;Role;Science;Scientist;Site;spatiotemporal;structural biology;Students;Support Groups;symposium;Synapses;System;Techniques;Technology;therapeutic RNA;Time;Tissues;Training;Translational Regulation;Translations;Travel;Underrepresented Minority;Visualization;Woman

PROJECT_TITLE: RNA Localization and Local Translation

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-K (43)]


PHR: Project Narrative Dilated cardiomyopathy is a common cause of heart failure that is associated with reduced cardiac contractility. This project tests the hypothesis that the contractile dysfunction results from the myosin motors being shifted towards a super-relaxed state where they cannot contribute to force-generation.

PI_NAMEs: WELLETTE-HUNSUCKER, AUSTIN  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Actins;Adrenergic Agents;Adrenergic beta-Antagonists;Angiotensin-Converting Enzyme Inhibitors;Attention;Binding;Biochemical;Biochemistry;Biological Assay;Calcium;canine model;Cardiac;Cardiac Myosins;Control Groups;Coupled;Depressed mood;Dilated Cardiomyopathy;Disease;Disease Progression;DNA Sequence Alteration;Doctor of Philosophy;Drug abuse;Endocrine;Enzymes;Equilibrium;Event;Exhibits;experimental study;Functional disorder;gel electrophoresis;Generations;genetic regulatory protein;Goals;Heart;Heart failure;Human;insight;Investigation;Ischemia;Left;Length;Link;Measures;Mediating;meter;Molecular;Molecular Conformation;Motor;Myocardial;Myocardium;Myosin ATPase;Myosin Regulatory Light Chains;myosin-binding protein C;NADH;novel;Patients;Permeability;Phosphorylation;Physiologic pulse;Prevalence;prevent;Principal Investigator;Production;Protein Dephosphorylation;Proteins;Pump;Regulation;Relaxation;Role;Sampling;Sarcomeres;Signal Transduction;Signaling Protein;Source;Stress;Sturnus vulgaris;Symptoms;Techniques;Testing;Therapeutic;Thick Filament;Thin Filament;Training;Translational Research;Transplantation;Ventricular;Virus Diseases;Western Blotting;Work

PROJECT_TITLE: The myosin super-relaxed state and human dilated cardiomyopathy


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Histotripsy is an emerging noninvasive, nonthermal, and nonionizing tumor treatment that uses focused ultrasound to mechanically destroy tissue. Recently, histotripsy underwent a successful Phase I human clinical trial for treatment of liver tumors, however, only ~50% of tumors in the liver can currently be treated due to an inability to visualize and target the tumors using a transcostal approach. In this grant, we will characterize the effects of ribs on histotripsy targeting, develop a model to predict tumor-specific offsets when targeting through the ribs, and implement the targeting technique real-time in preclinical, large animal and tumor models.

PI_NAMEs: FALK, KATRINA LAUREN (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: 3-Dimensional;Acoustics;Adoption;Agar;Alcoholic Liver Diseases;Animal Model;Animals;Area;Bathing;Cancer Etiology;Cells;Cessation of life;Clinical;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;cohort;cone-beam computed tomography;Coupled;Data;Data Set;Dependence;Development;Diagnostic;dimensional analysis;Disease;Eligibility Determination;Ethanol;Europe;experimental study;Failure;Family suidae;Fluoroscopy;Focused Ultrasound;Focused Ultrasound Therapy;Foundations;Future;Gases;Goals;Grant;Hepatitis B;Hepatitis C;Histologic;Human;Image Analysis;image guided;image guided intervention;imaging modality;Immune;improved;in silico;in vivo;in vivo Model;individualized medicine;Intervention;Kidney;Liver;Liver diseases;Liver neoplasms;Location;Machine Learning;machine learning algorithm;machine learning model;Malignant neoplasm of liver;Measures;Mechanics;metabolic-associated fatty liver disease;Metastatic Neoplasm to the Liver;Methods;Modality;Modeling;nanoscale;novel;Organ;Oryctolagus cuniculus;Pancreas;Patient Selection;Patients;Pelvis;Phase;Physicians;Physiologic pulse;porcine model;Positioning Attribute;pre-clinical;preclinical study;Prevalence;Primary carcinoma of the liver cells;Process;Property;prospective;radiological imaging;Resources;Retroperitoneal Space;rib bone structure;Roentgen Rays;Safety;Scientist;simulation;Site;sound;Speed;Spleen;standard of care;Stress;Techniques;Testing;Therapeutic;Thermal Ablation Therapy;Time;Tissues;Training;training data;Transducers;Translations;Treatment Efficacy;treatment planning;tumor;Ultrasonic Therapy;Ultrasonic Transducer;Ultrasonography;ultrasound;Validation;Visualization;Water;X-Ray Computed Tomography

PROJECT_TITLE: Developing an Accurate and Robust Targeting Technique to Enable Transcostal Histotripsy Treatment of Liver Tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

PHR: Project Narrative Activating mutations in platelet derived growth factor receptor beta have recently been discovered in humans to cause Penttinen Syndrome leading to multiple craniofacial defects. These studies will expand the current understanding of PDGFRb signaling and will illuminate how elevated signaling leads to craniofacial defects in humans. Furthermore, the results of these studies may inform the adjacent fields of cancer and cardiovascular disease as there is evidence of upregulated PDGF signaling in these diseases as well.

PI_NAMEs: KIM, JANG HOON (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Acro-Osteolysis;Address;aged;Apoptosis;Appearance;Atrophic;Binding;Binding Sites;Bioinformatics;Blood capillaries;bone;Calvaria;Cardiovascular Diseases;Cells;Cephalic;Childhood;Cleavage Under Targets and Release Using Nuclease;craniofacial;Craniofacial Abnormalities;craniofacial development;Craniosynostosis;cranium;Data;Defect;Dermal;Development;differential expression;Dimerization;Disease;Embryo;Embryonic Development;Exhibits;extracellular;Gene Expression;gene repression;Genes;Genetic Transcription;genomic data;Genotype;Goals;High-Throughput Nucleotide Sequencing;Human;human disease;Knock-out;Knowledge;Ligand Binding;Ligands;Malignant Neoplasms;Mediating;Mediator;Meningeal;Meninges;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Microaneurysm;migration;Modeling;Molecular;Molecular Conformation;mouse model;Mus;mutant;Mutation;overexpression;Patients;PDGFRB gene;Pericytes;Phenotype;Phosphorylation;Phosphotransferases;PIK3CG gene;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Point Mutation;premature;Process;Proliferating;promoter;Proteins;Purpura;Rare Diseases;receptor;Receptor Protein-Tyrosine Kinases;response;Role;Sampling;Signal Transduction;skills;STAT1 protein;Syndrome;Testing;Thinness;Tissues;transcription factor;transcriptome sequencing;Tyrosine;Visualization

PROJECT_TITLE: Understanding the role of PDGFRb signaling in Penttinen syndrome craniofacial development

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: Ciudad Aut?noma de Buenos Aires

ORG_COUNTRY: ARGENTINA

ORG_FIPS: AR

ORG_NAME: NATIONAL COUNCIL SCIENTIFIC & TECH RES

PHR: Project narrative During their movements, birds can disperse infectious agents (bacteria, viruses) and ectoparasites (ticks, fleas, lice) representing an important mode of transport of emerging pathogens. Wetlands are known to serve as hotspots for resident bird diversity as well as a stopover and overwinter sites for migratory birds, since they are stable ecosystems, with high food productivity. We intend to use this study as a foundation to understanding how wetlands works as hub for arboviruses exchange and spillover in an interconnected wetland networks across the Americas.

PI_NAMEs: DIAZ, ADRIAN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Americas;Animal Migration;Arboviruses;Argentina;arthropod-borne;Attention;Bacteria;Biological;Biological Assay;Birds;Blood;Central America;climate change;Competence;Country;Culex (Genus);Culicidae;cytochrome c oxidase;density;Destinations;Detection;Ecosystem;emerging human pathogen;emerging pathogen;Emigrations;environmental change;Flavivirus;Fleas;Food;Foundations;Genotype;Geography;Habitats;Hibernation;Human;Infectious Agent;Lice;Mediating;migration;migratory bird;Molecular;mosquito-borne;Movement;neutralizing antibody;North America;Phylogenetic Analysis;Prevalence;Productivity;Province;Rest;Role;Route;Seasons;Series;Seroprevalences;serosurveillance;serosurvey;Site;Social Change;South America;St. Louis Encephalitis Virus;Systemic Lupus Erythematosus;Ticks;Time;transmission process;Transportation;United States;urban area;vector;Viral;Virus;virus host interaction;West Nile virus;Work

PROJECT_TITLE: Wetlands in Argentinaas hubs for exchange and emigration of bird-borne arboviruses

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 SAS-W (J1)]