NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  VSMC phenotypic switch and calcification play important roles in the development of atherosclerosis. The current application seeks to fill the scientific gaps by developing a novel paradigm underlying the regulation of VSMC phenotypic switch and calcification in atherosclerosis by the PRMT1/Runx2 signaling network, which should advance our understanding of basic mechanisms governing VSMC phenotypic modulation in atherosclerosis; and also have broader scientific impacts in maintaining SMC homeostasis and vascular integrity, and improve vascular health. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page Continuation Format Page

PI_NAMEs: CHEN, YABING  (contact);ZHAO, XINYANG

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: acute myeloid leukemia 1 protein;Aging;Aorta;Apolipoprotein E;Arginine;Arterial Fatty Streak;arterial stiffness;Atherosclerosis;Blood Vessels;bone;calcification;Calcium;Cardiovascular system;Cells;ChIP-seq;Chronic Kidney Failure;Clinical Research;Complex;Deposition;design;Development;Diabetes Mellitus;Diet;Disease;DNA Binding;Down-Regulation;Elasticity;experimental study;gain of function;Genes;Genetic Markers;Genetic Transcription;Health;Homeostasis;Human;human tissue;improved;In Vitro;in vivo;Kidney Diseases;Link;Lipids;loss of function;Malignant Neoplasms;Mediating;Methylation;Molecular;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;myocardin;novel;osteogenic;Oxidative Stress Induction;Pathogenesis;Pathologic;Pathologic Processes;Phenotype;Play;protein arginine methyltransferase 2;Protein-Arginine N-Methyltransferase;Proteins;Proteomics;Regulation;Role;Serum Response Factor;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Testing;therapy development;transcription factor;transcriptomics;Transgenic Mice;Transgenic Organisms;Up-Regulation;Vascular calcification;Vascular Diseases;Vascular Smooth Muscle;Vascular Smooth Muscle Tissue

PROJECT_TITLE: Protein Arginine Methylation in Vascular Smooth Muscle Cell Phenotypic Modulation and Calcification


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: NORTHEASTERN UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative: Public Health Relevance: Monocytes and macrophages play major roles in many human diseases including infection, atherosclerosis, and cancer (tumor associated macrophages). In these different contexts, they have different polarizations that are incompletely understood. Here I propose experiments that can help us better understand their polarization and thus inform future therapeutic modalities.

PI_NAMEs: SLAVOV, NIKOLAI  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: aerobic glycolysis;Algorithms;Atherosclerosis;Automobile Driving;Biomedical Research;Cells;Data;Data Analyses;Environment;experimental study;Future;Genetic;Genetic Transcription;Goals;Human;human disease;Immune response;Infection;Macrophage;Macrophage Activation;Maintenance;Malignant Neoplasms;Masks;Measurement;Mediating;Metabolic;Metabolism;Methods;Modality;Molecular;monocyte;pathogen;Pattern;pharmacologic;Physiological;Play;Population;Population Analysis;Positioning Attribute;Process;Property;Proteins;public health relevance;Research;Resolution;response;Role;Shapes;Signal Transduction;single cell analysis;System;Testing;Therapeutic;tissue regeneration;transcriptomics;Tumor-associated macrophages;Variant

PROJECT_TITLE: Molecular and metabolic influences on the activation of monocytes and macrophages at single-cell resolution

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative ATP-sensitive potassium (KATP) channels regulate membrane excitability according to the energetic state of a cell, and dysfunction of these channels underlie a number of devastating human diseases. The goal of this project is to understand the structural mechanisms governing the activity of various KATP channel subtypes found in different tissues in order to design better drugs to treat diseases caused by channel dysfunction.

PI_NAMEs: SHYNG, SHOW-LING  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: ATP-Binding Cassette Transporters;Binding;Biological Assay;biophysical properties;Blood Vessels;Cantu syndrome;Cardiac;Cardiovascular Diseases;Cell Energetics;Cells;Complex;Cryoelectron Microscopy;design;Disease;DNA Sequence Alteration;drug discovery;Drug or chemical Tissue Distribution;Endocrine System Diseases;Functional disorder;gain of function mutation;Goals;Health;Homeostasis;Human;human disease;Hypotension;in silico;inhibitor;innovation;inward rectifier potassium channel;Ion Channel;Knowledge;Literature;Membrane;Membrane Proteins;Molecular Conformation;molecular dynamics;Mutation;Myopathy;Neurons;Nucleotides;Outcome;Pancreas;particle;Patients;Pharmaceutical Preparations;Pharmacology;Physiological Processes;Potassium;Property;protein complex;Protein Isoforms;Publishing;Regulation;Research Personnel;Resolution;screening;sensor;Structure;Structure-Activity Relationship;sulfonylurea receptor;Testing;three dimensional structure;Tissues;Vascular Smooth Muscle

PROJECT_TITLE: Correlating structure and function in KATP channel isoforms


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We aim to determine the molecular requirements for healthy skeletal muscle function, in order to pave the way for discovery and design of more effective therapies for muscle disease and weakness. Our work will answer crucial questions about how the protein myosin-binding protein C (MyBP-C), a cause of distal arthrogryposis, functions in skeletal muscle, using reporter probes to visualize dynamic protein structures in contracting muscle cells. This research will greatly improve the human health prospects for understanding disease by determining effects of disease mutations and developing tools that can be used to discover novel treatments.

PI_NAMEs: COLSON, BRETT A (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Actins;Actomyosin;Address;Affect;Anisotropy;Arthrogryposis;Artificial skin;Binding;Biological Assay;biophysical tools;Cardiac Myosins;Contracts;Contracture;Cyclic AMP-Dependent Protein Kinases;Deceleration;design;Development;Disease;Distal;effective therapy;Equilibrium;Evaluation;experimental study;Fiber;Fluorescence;Fluorescence Resonance Energy Transfer;Frequencies;Gel;Genes;Health;Human;Hypertrophic Cardiomyopathy;improved;In Situ;In Vitro;in vivo;innovation;Joints;Kinetics;Knock-out;Knockout Mice;Knowledge;Label;Length;Live Birth;Lower Extremity;Mass Spectrum Analysis;Measures;Mediating;Medical;Microfilaments;Molecular;Molecular Conformation;Monitor;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;Muscle function;Muscle Proteins;Muscle Weakness;mutant;Mutant Strains Mice;Mutation;Myocardial;Myopathy;Myosin ATPase;myosin-binding protein C;N-terminal;Nonmuscle Myosin Type IIA;novel;novel therapeutics;Outcome;Pathogenicity;Performance;Permeability;Phosphoproteins;phosphorescence;Phosphorylation;Physiological;Positioning Attribute;Post-Translational Protein Processing;prevent;Protein Dynamics;Protein Isoforms;protein structure;Proteins;Publishing;Recombinants;Regulation;Reporter;Reporting;Research;Resolution;RNA Splicing;Role;Sampling;Sarcomeres;sensor;Site;skeletal;Skeletal Muscle;Slide;spectroscopic data;Stains;Structure;Structure-Activity Relationship;Testing;Therapeutic;Thick Filament;Thin Filament;Time;time use;tool;Tropomyosin;Upper Extremity;Variant;Visualization;Work

PROJECT_TITLE: Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative:  Of the many examples of cellular trans-differentiation and reprogramming in the research literature, very few if any efficiently generate new cells that exhibit terminal differentiation suitable for cellular therapeutics and disease modeling. In the past funding periods of my two grants that converge into this R35 application, our laboratory has found that genes residing in particular varieties of chromosomal condensation, known as H3K9me3-heterochromatin, are refractory to activation during trans-differentiation and reprogramming. The present application uses a research environment for diversity, equity, and inclusion to bring together diverse technologies and cellular systems to understand how gene regulatory proteins overcome the heterochromatin barrier and to apply the information to create more differentiated cells for therapeutics and disease modeling.

PI_NAMEs: ZARET, KENNETH  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Amino Acids;Binding;Biochemical;Categories;Cell Culture Techniques;Cell Differentiation process;Cell Fate Control;Cell Reprogramming;Cell Therapy;cell type;Cells;Chromatin;Chromosomes;Deoxyribonucleases;disease model;DNA;Enabling Factors;Environment;equity, diversity, and inclusion;Event;Exhibits;Funding;Gene Expression Regulation;gene repression;Genes;Genetic;genetic approach;genetic regulatory protein;Genetic Transcription;Genomics;Goals;Grant;Heterochromatin;Histones;improved;In Vitro;in vivo;insight;knock-down;Laboratories;Licensing Factor;Literature;Mus;Nucleosomes;Physical condensation;Proteins;reconstitution;Refractory;Research;Resistance;single molecule;System;Technology;Tertiary Protein Structure;Therapeutic;transcription factor;transdifferentiation;Work;XCL1 gene

PROJECT_TITLE: Transcription Factors Overcoming Chromatin Barriers to Control Cell Fate


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Gene Therapy;Genetics;Regenerative Medicine;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Islet transplantation replaces the lost insulin-producing pancreatic islet beta cells due to type 1 diabetes. However, this therapy is not widely used because of its variable efficacy and the requirement for life-long immunosuppression that can lead to a whole host of problems. We will tackle these issues using genetic engineering to help islet to withstand the stress of transplantation and resist immune attacks. The goal is to develop strategy for highly efficient islet transplantation without the need of immunosuppression.

PI_NAMEs: MCMANUS, MICHAEL T;TANG, QIZHI  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Ablation;Address;antagonist;arm;base editing;Beta Cell;beta cell replacement;CD28 gene;Cell Death;cell replacement therapy;Cell Survival;Cells;Cellular biology;Cellular Infiltrate;Cellular Stress;Cessation of life;Chronic;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Complementary DNA;CRISPR interference;curative treatments;cytokine;Data;efficacy testing;Engineering;Engraftment;Environment;experience;experimental study;gene-editing approach;Genes;Genetic Engineering;genome editing;Glucose;Goals;high throughput screening;Histocompatibility Antigens Class I;HLA Antigens;Human;humanized mouse;Hypoxia;IFNAR1 gene;IL1R1 gene;Immune;Immune Evasion;immune function;Immune response;Immune system;Immunocompetent;immunogenic;immunogenicity;Immunologics;Immunosuppression;improved;in vivo;Inbred NOD Mice;Individual;Inflammation;Inflammatory;Insulin;Insulin-Dependent Diabetes Mellitus;intercellular cell adhesion molecule;Interferons;Interleukin-1;Intervention;Ischemia;ischemic injury;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Knowledge;Laboratories;Mediating;Metabolic;Modality;mouse model;novel;nutrient deprivation;overexpression;Pancreas;Pathway interactions;prime editing;Research;revascularization;Risk;RNA Interference;RNA interference screen;Screening procedure;Secondary to;somatic cell gene editing;stem cells;Stress;Structure of beta Cell of islet;synthetic biology;Systems Biology;Testing;Tissues;TNF gene;TNFRSF1A gene;Toxic effect;trafficking;Transplantation;Transplantation Immunology;Treatment Efficacy;vascular bed;Vascular blood supply;Vascular regeneration;Vascularization;Vision;Work

PROJECT_TITLE: Genome editing of human pancreatic islets to withstand ischemic injuries and promote immune evasion


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: VILLALONGA OLIVES, ESTER  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: Belief;Black Populations;Complex;Data;Data Sources;Dimensions;Discrimination;economic indicator;Economics;effective intervention;Epidemiologist;Ethnic Population;Health;health determinants;health disparity;health inequalities;Health Promotion;Healthcare;Hispanic;Hispanic Populations;indexing;Individual;inequitable distribution;Institution;Latino Population;marginalized population;Measurement;Measures;Modernization;multi-racial;Nature;novel;Outcome;Pattern;Persons;Policies;Population;Psychometrics;Public Health;Race;Racial Equity;Racial injustice;racial population;Research;Resources;Sampling;social;social disparities;Societies;sound;Spanish/English;Structural Racism;System;Techniques;Testing;theories;tool

PROJECT_TITLE: Assessing intersectional, multilevel and multidimensional structural racism for English- and Spanish-speaking populations in the US


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: Project Narrative There is an urgent need to provide high-quality survivorship care to the rapidly growing population of adolescent and young adult (AYA) cancer survivors. The new National Standards for Cancer Survivorship Care provide a robust framework for developing and assessing survivorship care programs across and within U.S. healthcare systems. We will leverage our existing large contemporary cohort of AYA cancer survivors cared for within Kaiser Permanente to: 1) Examine the availability of the new National Standards within KP; 2) Assess referral to and utilization of recommended National Standards within our KP AYA cancer survivor cohort; the proposed work will be a supplement to our current program grant (P01CA233432).

PI_NAMEs: HAHN, ERIN ELIZABETH;KUSHI, LAWRENCE H (contact)

PROGRAM_OFFICER_NAME: SMITH, ASHLEY

PROJECT_TERMS: Accident and Emergency department;Address;Administrative Supplement;Adolescent and Young Adult;Adolescent and young adult cancer patients;Aftercare;Age Years;Area;Behavior;cancer diagnosis;cancer recurrence;Cancer Survivor;cancer survivorship care;cancer therapy;care coordination;care systems;Caring;Characteristics;Chronic;clinical care;cognitive development;cohort;Colonoscopy;Complex;Comprehensive Cancer Center;Data;Development;Diagnosis;Disease;Education;Elements;Emotional;Employment;Ethnic Origin;Evaluation;experience;Family;Financial Hardship;Funding;Future;Grant;Guidelines;health assessment;health care disparity;Health system;Healthcare;Healthcare Systems;improved;Inequity;insight;Insurance Coverage;Integrated Health Care Systems;interest;Intervention;Late Effects;Leadership;Life;Life Style;Malignant Neoplasms;Mammography;Measures;Medical Records;medical specialties;Morbidity - disease rate;National Cancer Institute;National Comprehensive Cancer Network;Oncology;Outcome;patient population;patient stratification;Physical assessment;Physical therapy;Policies;Population;Premature Mortality;Preventive care;primary care services;Process;programs;psychologic;Race;Recommendation;Recurrence;response;Risk;screening;Services;social;Social Development;Socioeconomic Status;Structure;Supportive care;Survivors;survivorship;Vaccination;Visit;Work

PROJECT_TITLE: Clinical Care Gaps and Unmet Needs in Adolescent and Young Adult (AYA) Cancers


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

PHR: Project Narrative  The goal of the parent grant is to dissect the evolution of the multi-protein, multi-functional protein complexes formed by Toll-like receptor 4 (TLR4). TLR4 is an important driver for inflammation in both healthy and pathological contexts. It evolved the ability to form complexes with a wide variety of protein partners. The equipment supplement will be used to acquire instrumentation that will allow us to directly study the assembly of these complexes and thus better understand their biochemistry and function.

PI_NAMEs: HARMS, MICHAEL JONATHAN (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Agonist;Binding;Biochemistry;CD14 Antigen;CD14 gene;Chronic;Complex;Equipment;Evolution;Funding;Goals;High Pressure Liquid Chromatography;Infection;Inflammation;instrument;instrumentation;Lasers;light scattering;Malignant Neoplasms;Measures;parent grant;parent project;Pathologic;protein complex;protein function;protein protein interaction;Proteins;response;S100A9 gene;System;TLR4 gene;tool;wound healing

PROJECT_TITLE: Evolution of new protein function in the multi-protein, multi-functional Toll-like receptor 4 complex


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Not applicable.

PI_NAMEs: CHOOK, YUH MIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Antineoplastic Agents;Binding;Biochemical;Bioinformatics;Biological;Cell Nucleus;Cell Physiology;Cells;Chemicals;Collection;Complex;Cytoplasm;design;Development;Disease;experimental study;Exportins;Food and Drug Administration Drug Approval;Gene Expression;Grant;Histones;Importins;inhibitor;Karyopherins;Knowledge;Learning;Ligands;Maps;Mediating;Messenger RNA;Molecular Chaperones;mRNA Export;Nuclear;Nuclear Export;Nuclear Import;Nuclear Localization Signal;Nucleosomes;Pathway interactions;Peptide Signal Sequences;Phosphorylation;prevent;Proline;protein transport;Proteins;Proteome;receptor;RNA-Binding Proteins;Signal Transduction;Tyrosine;Work

PROJECT_TITLE: Biochemical and cellular functions of Karyopherins - Revision - 2


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This project examines the phytochromes, a superfamily of photoreceptors that can detect to a broad range of colors and can transmit that information to the cell to control many aspects of biology. Plant phytochromes are a major stumbling block in improving agricultural yield by mediating the shade avoidance response caused by competition for light among neighboring plants, while their bacterial relatives have proven a valuable source of imaging reagents for biomedical research and of photosensory reagents for synthetic control of cellular processes with light. Work under this project will provide new insight into color tuning, the usage of light energy, the integration of light with signals such as temperature and pH, and the transmission of information within these photoreceptors and to the rest of the cell.

PI_NAMEs: LAGARIAS, JOHN CLARK (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Agriculture;Algae;Bacteria;Basic Science;behavioral response;Bilin;Binding;Biological Process;Biology;biomedical imaging;Biomedical Research;Biophysical Process;Cell Physiology;Cells;chromophore;circadian pacemaker;Color;Dependence;design;Detection;Development;Environment;Eubacterium;Evolution;Exhibits;Family member;Family Process;feeding;Flowers;Fluorescence;Food;fungus;Genes;Germination;Goals;Human;Image;Imaging Device;improved;insight;interest;Interphase Cell;knowledge base;Learning;Light;light intensity;LIGHT protein;Mediating;member;Metabolism;Methods;Microbial Biofilms;Mission;Molecular;Motility;National Institute of General Medical Sciences;Nature;new technology;Nucleotides;Organism;Output;Photoreceptors;phyA phytochrome;Phytochrome;plant growth/development;Plants;Population;Principal Investigator;Process;promoter;Protein Family;Protein Kinase;Proteins;Reagent;Reporting;Reproduction;Research;response;Shapes;Signal Transduction;Source;synthetic biology;System;Systems Biology;Targeted Research;Temperature;Tetrapyrroles;Tissues;transcription factor;transmission process;ultraviolet;Work

PROJECT_TITLE: Understanding and leveraging molecular diversity within the phytochrome superfamily


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Clinical Research;Dissemination and Implementation Research;Genetics;Health Services;Human Genome;Pediatric;Prevention;Primary Health Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Genomic medicine seeks to improve clinical outcomes and public health, and identification of clinically actionable inherited genetic conditions before symptoms manifest can enable physicians to intervene earlier and achieve these goals. The newborn screening program exemplifies this paradigm but is limited to a narrow subset of conditions relevant at birth, thereby missing the opportunity to identify many other similarly actionable conditions. Given the many challenges associated with clinical whole genome sequencing in the newborn period, we propose to expand the scope of genomic screening by offering parents targeted sequencing of their children at distinct time-points during development, to discover actionable genetic conditions when that information would have the greatest relevance.

PI_NAMEs: BERG, JONATHAN S (contact);MILKO, LAURA VOGEL

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Address;Adult;Age;age group;Age of Onset;Applied Genetics;Awareness;Benefits and Risks;Biological Assay;Birth;Child;Child Care;Child health care;Childhood;Clinic;Clinical;clinical trial implementation;clinically actionable;clinically relevant;Collaborations;Communities;community based participatory research;community clinic;community engagement;Consensus;Data;Decision Making;design;Development;Disease;economic outcome;education resources;Eligibility Determination;Ethics;Expert Opinion;Feedback;Future;Genetic Diseases;genetic information;Genetic Medicine;genetic variant;genome sequencing;genome-wide;Genomic medicine;Genomics;Goals;Health;health economics;Healthcare;implementation facilitators;implementation framework;implementation outcomes;implementation strategy;implementation trial;improved;Individual;infancy;Infant;Inherited;innovation;Intervention;Interview;Laboratories;Leadership;life span;Longitudinal Studies;Maps;Measures;Methods;Modeling;Neonatal Screening;Newborn Infant;novel;organizational readiness;Outcome;Parents;Perception;Physicians;Pilot Projects;Population;pragmatic study;prevent;Primary Care;primary care setting;Process;programs;Protocols documentation;Provider;Public Health;Qualitative Methods;rare mendelian disorder;reduce symptoms;Research;research and development;Resources;Risk;screening;screening program;Screening Result;Site;social;Specific qualifier value;Symptoms;targeted sequencing;Technology;technology validation;Time;Training;Training and Education;Treatment Efficacy;Underrepresented Populations;Underserved Population;Variant;Well Child Visits;whole genome;Work

PROJECT_TITLE: Age-based genomic screening in newborns, infants, and children: a novel paradigm in public health genomics


ORG_CITY: BERKELEY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE With the support of our current award, we are investigating microscale mechanisms through which cells generate force and change shape during polarization and motility, particularly through confined spaces in tissue. Accomplishing these goals requires high-resolution and long-term live-cell imaging capabilities, and our laboratory's live-cell imaging system is nearly 20 years old and beginning to fail. We therefore request funding to support purchase of a brand new, state-of-the art optical imaging system that will greatly enhance our ability to execute and even transcend our originally proposed studies.

PI_NAMEs: KUMAR, SANJAY  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Biophysical Control of Cell Form and Function by Single Actomyosin Stress Fibers: Instrument Supplement


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Disability Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Sarcopenia;Telehealth

ORG_CITY: LYME

ORG_NAME: SYNCHROHEALTH LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Older adults diagnosed with sarcopenia (e.g., loss of muscle mass, strength, and function) or frailty, are typically prescribed at-home resistance-based exercises to maintain and enhance physical function. Such prescriptions rely on self-report patient compliance to confirm whether the exercises are conducted and whether their exercise fidelity is sufficient to promote functional recovery. Herein, we propose to optimize the BandPass system, a Bluetooth-enabled resistance exercise band, patient app, clinician dashboard, and a cloud-based infrastructure that automatically senses the continuous force exerted during exercises to enable remote monitoring, compliance checking, and exercise classification while helping to overcome the current gaps of clinically tailored home exercise programs.

PI_NAMEs: HALTER, RYAN JOSEPH (contact)

PROGRAM_OFFICER_NAME: FOX, JENNIFER THERESA

PROJECT_TERMS: Accelerometer;Acute;Address;Adherence;Affect;Age;age group;aging in place;Algorithms;American;Bluetooth;Businesses;Calibration;Caring;Cessation of life;Classification;classification algorithm;Clinical;clinically relevant;cloud based;Cognitive;commercialization;Computer software;computing resources;Consumption;cost;Custom;dashboard;Data;Data Collection;data communication;data dashboard;data exchange;Data Science;data visualization;design;Device Designs;Devices;Diagnosis;diaries;disability;disability risk;Distal;Drops;Elasticity;Electronics;evidence base;Exercise;exercise adherence;exercise physiologist;exercise program;exercise training;experience;Feedback;frailty;functional decline;Future;Goals;Hand Strength;handheld mobile device;Health;Healthcare;Home;Hour;Housing;improved;Infrastructure;innovation;Institutionalization;Internet;Interview;Lead;machine learning algorithm;manufacture;Marketing;Measurement;Measures;Medical Device;Methods;mHealth;mobile application;Monitor;monitoring device;Morbidity - disease rate;Motion;muscle form;muscle hypertrophy;muscle regeneration;muscle strength;Muscular Atrophy;Musculoskeletal;Non-Invasive Detection;novel;older adult;operation;Outcome;Pain;Patient Compliance;Patient Monitoring;Patient Monitoring System;patient oriented;Patient Self-Report;Patients;Persons;Phase;Physical Function;Physical Performance;physical therapist;Physicians;Pilot Projects;Positioning Attribute;Predictive Analytics;preservation;Procedures;Production;Quality of life;Recommendation;Recovery;Recovery of Function;Recreation;remote monitoring;remote patient monitoring;remote sensing;Reporting;Research Design;Resistance;resistance exercise;Resolution;Resources;Risk;sarcopenia;satisfaction;Self-Help Devices;sensor;Services;Site;Small Business Technology Transfer Research;Sports;standard care;Structure;success;Surveys;System;Technology;Testing;Time;Training;transmission process;Tube;usability;user centered design;user-friendly;validation studies;Variant;verbal;Vision;Visual;Writing

PROJECT_TITLE: BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative - Overall X-ray crystallography, solution scattering and X-ray footprinting are critical tools in the study of biological systems. They provide information that has been a prerequisite to understanding the fundamentals of life. They are also methods that have proved themselves to be central to the development of new therapeutics for human disease. The overarching goal of this proposal is to provide an integrated synchrotron Resource that makes mature technologies available to a broad research community. This will lead to more insightful biological interpretation and better drugs to improve human health.

PI_NAMEs: ADAMS, PAUL DAVID (contact);HURA, GREGORY L

PROJECT_TERMS: 2019-nCoV;Automation;beamline;Biocompatible Materials;Biological;biological systems;California;Collection;Communities;Complex;Country;Coupling;Cryoelectron Microscopy;Crystallization;Crystallography;Data;Data Analyses;Data Collection;data quality;Data Set;design;Development;Disease;Education and Outreach;Educational workshop;Effectiveness;Ensure;Exclusion;experience;experimental study;flexibility;Fluorescence Spectroscopy;Goals;Health;Human;human disease;improved;In Situ;Individual;Infrastructure;instrument;Internet;Investigation;Journals;Life;Ligands;Light;macromolecular assembly;Mass Spectrum Analysis;meetings;member;Methods;novel therapeutics;Office of Administrative Management;operation;outreach;pathogen;Peer Review;Performance;Pharmaceutical Preparations;Productivity;programs;Proteome;Publications;Raman Spectrum Analysis;recruit;Research;Research Personnel;Resources;response;Roentgen Rays;Route;screening;Site;small molecule;Source;structural biology;Structure;success;Synchrotrons;Techniques;Technology;Temperature;Testing;tool;Training;Work;X-Ray Crystallography

PROJECT_TITLE: ALS Efficiently Networking Advanced Beam Line Experiments (ALS-ENABLE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PI_NAMEs: ELLIOTT, DAWN M (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Advisory Committees;Annual Reports;Attention;Basic Science;Biological;career development;Clinical Research;Collaborations;Communication;Communities;Complex;Cues;Data;Delaware;Development;Development Plans;Disease;Ensure;Evaluation;Extramural Activities;Faculty;formative assessment;Functional disorder;Funding;Future;Goals;Grant;Growth;Health;improved;Infrastructure;Leadership;meetings;Mentors;Musculoskeletal;Musculoskeletal Diseases;novel;Office of Administrative Management;operation;Periodicals;pre-clinical;pre-clinical research;Program Development;Program Evaluation;programs;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Structure;success;Therapeutic Intervention;Tissues;tool;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Delaware Center for Musculoskeletal Research – Administrative Core


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cerebrovascular;Neurosciences;Rehabilitation;Stroke

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PI_NAMEs: KAUTZ, STEVEN A. (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Accountability;Address;Administrative Supplement;Advisory Committees;bioimaging;Biology;Biomechanics;Biomedical Engineering;Biomedical Research;Brain;career;Centers of Research Excellence;Clinical;Collaborations;college;Communication;cost;dashboard;Data;Decision Making;design;Development;Discipline;Doctor of Philosophy;Evaluation;experience;Extramural Activities;Fostering;Funding;Future;Goals;Grant;Health Occupations;Human Resources;improved;Individual;Information Dissemination;Infrastructure;infrastructure development;innovation;Inpatients;Institution;Interdisciplinary Study;International;Lead;Leadership;Medical;Medicine;meetings;Mentors;Modeling;Modification;Monitor;multidisciplinary;novel;Office of Administrative Management;operation;Outcome Assessment;Peer Review;Peer Review Grants;Performance;Phase;Pilot Projects;Process;Program Evaluation;Program Research Project Grants;programs;Recovery;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resources;Schedule;Scheme;Science;Scientist;Services;Source;South Carolina;Strategic Planning;Stroke;stroke recovery;Structure;success;sustainable resource;Teacher Professional Development;technological innovation;tool;Universities;web platform;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Natural Products

PHR: Project Narrative A preparative HPLC comprising an ultra-high-pressure LC unit and automated collection will be used to significantly increase productivity and workflow towards the parent goals of R35GM130387, including the development of catalysts and catalytic reactions that modify or introduce functional groups site-selectively in complex molecules relevant to human health. The preparative HPLC is requested to enable rapid separation of constitutional isomers and stereoisomers of reactions involving non-volatile reactants and products, predominantly those generated by the functionalization of C–H bonds.

PI_NAMEs: HARTWIG, JOHN F (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Address;Alkylation;catalyst;Cells;Collection;Column Chromatography;Complex;Computer software;Constitution;Derivation procedure;Development;Equipment;functional group;Funding;Goals;Health;High Pressure Liquid Chromatography;Human;Hydrogen Bonding;instrument;Isomerism;Laboratories;metalloenzyme;Methods;Natural Products;oxidation;Parents;Pharmaceutical Chemistry;Productivity;Reaction;Research;Research Personnel;Site;Stereoisomer;System;Terpenes;Transition Elements;ultra high pressure;United States National Institutes of Health

PROJECT_TITLE: Discovery and Development of Organic Reactions Catalyzed by Transition Metals Valuable for Medicinal Chemistry


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: Project Narrative We will systematically explore epistatic interactions that drive evolution of antibiotic resistance with the ultimate goal of developing novel antibiotics and antibiotic treatment strategies that select against resistance. Towards this goal, we will study molecular evolution of the dihydrofolate reductase (DHFR) enzyme in Escherichia coli under antibiotic selection, and engineer mutant-specific competitive and allosteric DHFR inhibitors that can select against resistance-conferring DHFR mutations. Finally, we will develop and synthesize a novel class of molecules that we named “-lactamase traps” (or BLTs) to select against -lactamase genes in Gram-negative bacteria.

PI_NAMEs: TOPRAK, ERDAL  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;Biochemical;Biological Assay;Biological Sciences;Carbapenems;Cephalosporinase;Cephalosporins;Chemicals;Clinic;Clinical;Communicable Diseases;Cyclophosphamide;design;Dihydrofolate Reductase;Dihydrofolate Reductase Inhibitor;DNA Gyrase;Drug Targeting;effective therapy;Engineering;Enzymes;Escherichia coli;Evolution;FDA approved;fitness;Folic Acid;Future;Genes;Genetic;Genetic Epistasis;Genotype;Goals;Gram-Negative Bacteria;Health;Hydrolysis;In Vitro;Induced Mutation;inhibitor;innovation;Interdisciplinary Study;Lactamase;Lactams;Libraries;Life;Maps;Mathematics;Metabolism;Modeling;Modification;Molecular Evolution;Monobactams;Mutagenesis;mutant;Mutation;Names;Non-Steroidal Anti-Inflammatory Agents;novel;novel drug class;Operative Surgical Procedures;Pathway interactions;Patient-Focused Outcomes;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Procedures;Prodrugs;programs;Public Health;Research;Resistance;resistance mechanism;Role;Shapes;Site;small molecule;Testing;therapeutic target;Time;tool;treatment strategy;Trimethoprim;Trimethoprim Resistance;Variant

PROJECT_TITLE: Mapping epistatic interactions in molecular evolution of antibiotic resistance


ADMINISTERING_IC: HD

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Pediatric

ORG_CITY: ROCKVILLE

ORG_NAME: THE EMMES COMPANY, LLC

PI_NAMEs: ANAND, RAVINDER  (contact)

PROJECT_TERMS: Amendment;authority;Authorization documentation;Award;Best Pharmaceuticals for Children Act;Biological Products;Child;Childhood;Clinical;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Collaborations;Complement;Conduct Clinical Trials;Consultations;Contractor;Contracts;Data;Data Coordinating Center;data integration;data management;data quality;data sharing;data standards;Data Storage and Retrieval;Devices;Disease;Drug Kinetics;Drug usage;Good Clinical Practice;Guidelines;improved;Individual;information gathering;Infrastructure;International;Knowledge;Label;Leadership;Monitor;National Institute of Child Health and Human Development;Obstetric pharmacology;off-patent;Office for Human Research Protections;pediatric drug development;pediatric pharmacology;Pediatric Research;Pharmaceutical Preparations;Pharmacodynamics;Population;pre-clinical;preclinical study;preclinical trial;Preparation;Process;Program Development;programs;prospective;protocol development;Protocols documentation;Quality Control;Regulation;Reporting;repository;Research;Research Personnel;Role;Safety;Site;Specimen;Statistical Data Interpretation;statistics;Statutes and Laws;Structure;Therapeutic;Therapeutic Uses;Time;Training;Treatment Efficacy;treatment strategy;United States;United States Dept. of Health and Human Services;United States Food and Drug Administration;United States National Institutes of Health;United States Public Health Service;web site;Work

PROJECT_TITLE: DATA COORDINATING CENTER FOR THE BEST PHARMACEUTICALS FOR CHILDREN ACT (BPCA) - PTN


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research

ORG_CITY: SILVER SPRING

ORG_NAME: SOCIAL AND SCIENTIFIC SYSTEMS,  INC.

PI_NAMEs: BAYAT, NASTARAN  (contact)

PROJECT_TERMS: Accountability;Adverse event;Advertising;Amendment;Autoantibodies;Autoimmunity;Award;Back;Biological;Biological Specimen Banks;Biopsy;Blood;Classification;Clinical;Clinical Laboratory Information Systems;Clinical Research;Clinical Services;Clinical Trials Database;Collaborations;Collection;Conflict of Interest;Consent;Consent Forms;Contractor;Data;Data Analyses;data cleaning;Data Collection;Data Reporting;Databases;demographics;Development;Diagnosis;DNA;Enrollment;Ensure;Environmental Risk Factor;Equipment and supply inventories;Evaluation;Experimental Pathology;Fractionation;Funding Agency;Health;Hobbies;Human;Image;interest;International;Laboratories;Ligase;material transfer agreement;member;Monitor;Myositis;National Institute of Environmental Health Sciences;Nursing Research;Occupations;Outcome;Parents;Participant;patient screening;patient subsets;Patients;Performance;performance site;Periodicals;Peripheral Blood Mononuclear Cell;Physicians;Plasma;Procedures;Process;programs;Protocols documentation;Questionnaires;Recontacts;Records;recruit;Regulation;Reporting;repository;Research;Research Assistant;Research Personnel;research study;Research Support;Research Training;response;RNA;sample collection;Sampling;screening;Serum;Services;Signs and Symptoms;Site;Specimen;Spottings;Surveys;Syndrome;Test Result;Time;Tissues;United States Department of Veterans Affairs;United States Food and Drug Administration;United States National Institutes of Health;Update;Visit;Whole Blood;Work

PROJECT_TITLE: TASK ORDER 4R - ENVIRONMENTAL AUTOIMMUNITY GROUP (EAG) - STUDY SUPPORT


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Aging

ORG_CITY: FREDERICK

ORG_NAME: PRECISION BIOSERVICES, INC.

PI_NAMEs: LANGENBACH, KURT  (contact)

PROJECT_TERMS: Aging;Biological;Specimen

PROJECT_TITLE: BIOLOGICAL SPECIMENS' RECEIPT, STORAGE, MANAGEMENT AND DISTRIBUTION


NIH_SPENDING_CATS: Cancer

ORG_CITY: ALACHUA

ORG_NAME: ALCHEM LABORATORIES CORPORATION

ORG_STATE: FL

PI_NAMEs: TALTON, JAMES D (contact)

PROJECT_TERMS: base;Chemicals;Clinical Trials;Contractor;Contracts;Cyclic GMP;Development;Ensure;Equipment;Formulation;Human Resources;Kilogram;Laboratories;manufacture;Pharmaceutical Preparations;Pharmaceutical Resources;Pharmacology and Toxicology;Procedures;Process;Reproducibility;Retinoblastoma Protein;Services;small molecule;Solubility;Work

PROJECT_TITLE: SYNTHESIS OF NON-GMP SMALL MOLECULES Base Year Increment 2


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: FOUTS, TIMOTHY  (contact)

PROJECT_TERMS: Acceleration;Antigens;Clinical Trials;Contractor;Contracts;Databases;Development;Documentation;efficacy study;Engineering;Equipment and supply inventories;Good Manufacturing Process;HIV envelope protein;HIV vaccine;HIV-1;Human;immunogenicity;In Vitro;Investigational Drugs;Label;Laboratories;Laboratory Animals;manufacture;manufacturing run;nanoparticle;National Institute of Allergy and Infectious Disease;Phase;plasmid DNA;preclinical development;Preclinical Testing;Preventive vaccine;product development;Production;Proteins;Protocols documentation;prototype;quality assurance;Quality Control;research clinical testing;stability testing;Testing;Toxicology;Vaccines;Viral Vector

PROJECT_TITLE: cGMP Manufacture, Fill-Finish, Release, and Stability Testing of a Nanoparticle Based HIV Envelope Containing Vaccine


PHR: Project Narrative Oxygen metabolism is mediated by several metalloenzymes, and one of the most complicated and least understood of these is the oxygen-evolving complex in photosystem II containing a manganese-calcium cluster, which is the only enzyme in nature that is capable of oxidizing H2O to O2. This proposal is directed towards using the newly available ultra-fast X-ray free electron laser, to take snapshots of the geometric and electronic structural changes of photosystem II and its metal center, in real time under physiological conditions, to understand the mechanism of water oxidation and oxygen evolution, and extending our studies to the study of other related Fe/Mn/Ni containing metalloenzymes of importance.

PI_NAMEs: YACHANDRA, VITTAL  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: absorption;Aerobic;Atmosphere;Biochemical Reaction;Biological;Calcium;Catalytic Domain;Charge;Chemical Structure;Chemicals;Chemistry;cofactor;Complex;cryogenics;Data Collection;Data Correlations;density;Dioxygen;electronic structure;Electronics;Electrons;Enzymes;Evolution;Excision;geometric structure;isopenicillin N;Life;Light;Manganese;Mediating;Membrane Proteins;Metabolism;metalloenzyme;Metalloproteins;Metals;Methane;Natural regeneration;Nature;novel strategies;optical spectra;oxidation;Oxidation-Reduction;Oxygen;photosystem II;Physiologic pulse;Physiological;Process;protein complex;Protein Dynamics;protein structure;Proteins;Reaction;Ribonucleotide Reductase;Roentgen Rays;Role;Sampling;Signal Transduction;Source;Spectrum Analysis;Structure;Temperature;Time;Water;X ray diffraction analysis;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Taking Snapshots of Enzymatic Reactions Using X-ray Crystallography and Spectroscopy


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative Many transcription factors perform diﬀerent functions in diﬀerent cell types throughout animal development and dysregulation of this process can lead to human pathologies such as developmental disorders and cancer. This project will explore how cell type-speciﬁc protein-protein interactions allow the Drosophila Hox transcription factor Ultrabithorax (Ubx) to perform distinct chromatin remodeling activities in diﬀerent cell types. The proposed studies will provide insight into how a single transcription factor functions to specify multiple cell types throughout animal development.

PI_NAMEs: MUNCE, ROSS  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Animals;appendage;ATAC-seq;Binding;Biological Assay;C-terminal binding protein;cell fate specification;cell type;Cells;Chest;Chromatin;chromatin modification;chromatin remodeling;Chromatin Structure;Co-Immunoprecipitations;Development;developmental disease;Distal;DNA;DNA Binding;Drosophila genus;Ectopic Expression;Enhancers;Ensure;Enzymes;experimental study;gain of function;Gene Expression Profile;gene regulatory network;gene repression;Genes;genetic corepressor;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;Histones;Human Pathology;Individual;insight;interest;loss of function;Malignant Neoplasms;Mediating;Methods;Modeling;Modification;Morphogenesis;Morphology;mutant;Mutation;novel;Population;Positioning Attribute;Post-Translational Protein Processing;Process;programs;protein protein interaction;Reading;recruit;Regulation;Regulatory Element;Repression;Research;Role;segregation;Series;Specific qualifier value;Stereotyping;Structure;Techniques;Testing;Tissues;transcription factor;Wing;Work;Zinc Fingers

PROJECT_TITLE: Mechanisms controlling cell type-specific transcription factor activity in the development of serially homologous structures in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Trauma-related nightmares in Veterans are associated with poor clinical outcomes, greater substance use, and increased risk of suicide. In spite of an urgent need to reduce the burden of trauma-related nightmares, the underlying physiological changes accompanying their occurrence are poorly understood, and there are no clear evidence-based recommendations for their treatment. Limitations of current assessment procedures represent a barrier to improved care. In-laboratory sleep studies infrequently capture nightmares, limiting our knowledge of phenotypic markers and their response to treatment. This CDA-2 addresses these limitations by using extended, in-home sleep monitoring to capture physiological parameters associated with nightmare reports in Veterans, and assessing how these physiological features are altered throughout a cognitive- behavioral nightmare treatment. Results from this CDA-2 will increase understanding of trauma-related nightmare pathophysiology, and advance strategies for personalizing symptom management in Veterans.

PI_NAMEs: MILLER, KATHERINE ELIZABETH (contact)

PROJECT_TERMS: Accelerometer;actigraphy;active method;Address;Aftercare;Arousal;Attention;Attenuated;Behavioral;Biological Markers;Body Surface;Calibration;candidate marker;career;Caring;Chest;Clinical;clinical care;Clinical Research;Clinical Sciences;clinically significant;Cognitive;Cognitive Therapy;comparison control;Data;design;Detection;eligible participant;Environment;Event;evidence base;evidence based guidelines;Evidence based treatment;Exclusion;follow up assessment;Frequencies;Functional disorder;Goals;Home;Home environment;improved;improvement on sleep;Intervention;Knowledge;Laboratories;Mattresses;Measures;Methodology;Methods;Monitor;Movement;multimodality;Nightmare;Outcome;Parasympathetic Nervous System;Participant;Pattern;personalized medicine;personalized strategies;phenomenological models;phenotypic biomarker;physical conditioning;Physiological;Polysomnography;poor sleep;Post-Traumatic Stress Disorders;Procedures;Quality of life;Randomized;Relaxation;REM Sleep;Reporting;Research;research and development;Research Methodology;respiratory;response;Sampling;sensor;Severities;Signal Transduction;Sinus Arrhythmia;Sleep;Sleep Apnea Syndromes;Sleep disturbances;sleep physiology;Sleep Stages;Sleeplessness;substance use;suicidal behavior;suicidal risk;symptom management;Symptoms;System;Time;Training;Trauma;trauma exposure;traumatic stress;treatment comparison;treatment planning;treatment research;treatment response;Veterans

PROJECT_TITLE: Characterization of sleep with trauma nightmares using ambulatory sleep measurement


ORG_CITY: WORCESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative: This project seeks to describe the basic principles that govern maternal RNA recognition and regulation in early development. Analysis of how post-transcriptional regulatory mechanisms, and more broadly how maternally supplied proteins and mRNAs, contribute to cell fate specification events in early development will ultimately lead to a better understanding of how developmental processes fail in disease. This project focuses on regulation mediated by the 3’UTR of maternal RNAs, and includes a variety of experiments to establish which regulatory events are most important for reproductive health, and how regulation works at a mechanistic level.

PI_NAMEs: RYDER, SEAN PATRICK (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3' Untranslated Regions;Address;Atmosphere;Binding;Binding Sites;Biochemical;Biology;Caenorhabditis elegans;cell fate specification;Coupled;CRISPR/Cas technology;Development;Developmental Process;Disease;Embryo;Embryonic Development;Ensure;Event;experimental study;Fertilization;Genetic;genome editing;Germ Lines;In Vitro;in vivo;innovation;interdisciplinary approach;interest;Maps;Maternal Messenger RNA;Mediating;medical schools;Messenger RNA;mRNA Expression;mutant;Mutation;Nematoda;oocyte maturation;Oogenesis;Pattern;Pattern Formation;Phenotype;Positioning Attribute;Post-Transcriptional Regulation;posttranscriptional;Property;Proteins;Regulation;Regulatory Element;Reporter Genes;Reproduction;Reproductive Health;RNA;RNA Binding;RNA-Binding Proteins;Specificity;Technology;temporal measurement;Time;tool;Transcript;Transgenes;Untranslated Regions;Work

PROJECT_TITLE: Post-transcriptional regulation of germline mRNAs in C. elegans


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: ITHACA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The efforts of my research program have been directed at probing the actions of membrane receptors and their G protein signaling partners that influence cell growth, differentiation, and development. These studies have culminated in a series of exciting new discoveries that describe how these signal transduction pathways are linked to the assembly of multi-protein complexes that regulate the metabolic activities of cells and the biogenesis of extracellular vesicles, important in embryonic stem cell function, differentiation, cellular senescence and aging, and infectious disease. By probing the signaling mechanisms that regulate these metabolic complexes and the biogenesis and function of extracellular vesicles, together with elucidating their structural features, we expect to gain new insights into the critical roles they play in a broad spectrum of biology and disease, as well as highlight new targets and strategies for therapeutic intervention.

PI_NAMEs: CERIONE, RICHARD A. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Area;Bacteria;Biochemical;Biogenesis;Biological;Biological Process;Biology;cancer cell;cancer survival;cdc42 GTP-Binding Protein;Cell Aging;cell growth;cell growth regulation;cell motility;Cell Physiology;Cell Polarity;Cell Survival;Cells;Cellular biology;Characteristics;Cloning;Communicable Diseases;Complex;Cues;Development;Disease;embryonic stem cell;Environment;Epidermal Growth Factor Receptor;Evolution;extracellular vesicles;FRAP1 gene;genetic regulatory protein;Glutamine;Goals;Growth;GTP-Binding Proteins;Human;insight;intercellular communication;interdisciplinary approach;Knowledge;Laboratories;Link;Mediating;Membrane;Messenger RNA;Metabolic;Metabolism;Monomeric GTP-Binding Proteins;Multiprotein Complexes;Neuronal Differentiation;novel;Organism;Physiology;Play;Process;programs;protein complex;Protein Kinase;receptor;Research;RNA Splicing;Role;Series;Signal Transduction;Signal Transduction Pathway;Signaling Protein;stem cell function;Therapeutic Intervention;three dimensional structure;Up-Regulation;Yeasts

PROJECT_TITLE: Studies of Global Signal Transduction


ADMINISTERING_IC: EY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Glaucoma is the leading cause of irreversible blindness throughout the world, and there are currently no options for restoration of vision in persons with blindness caused by this disease. Here we propose a series of novel strategies to advance the audacious goal of replacing retinal ganglion cells (RGCs), the output nerve cells of the eye, which form the optic nerve and are damaged in glaucoma. We will systematically test a series of manipulations to enhance the survival and integration of human induced pluripotent stem cell-derived RGCs in the glaucomatous retina.

PI_NAMEs: FORTUNE, BRAD ;MEYER, JASON STEPHEN (contact);OU, YVONNE ;SIVYER, BENJAMIN M

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: Anatomy;Astrocytes;Axon;Biology;Blindness;Brain;cell age;cell injury;Cell Survival;Characteristics;Communities;designer receptors exclusively activated by designer drugs;Disease;Electrophysiology (science);Environment;experimental study;Eye;FRAP1 gene;Genetic;Glaucoma;glial activation;Goals;Human;human induced pluripotent stem cells;Immunosuppressive Agents;improved;induced pluripotent stem cell;Knowledge;Modeling;Neuroglia;neuroinflammation;Neurons;novel strategies;Optic Nerve;optic nerve disorder;Output;overexpression;Persons;Process;receptor;Rejuvenation;Resources;Retina;retina transplantation;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal neuron;Series;sight restoration;sound;synaptogenesis;Testing;Thrombospondins;Translations;transmission process;Transplantation;Vision Disorders;Visual;Visual impairment;Visual System;Visually Impaired Persons

PROJECT_TITLE: Overcoming Barriers to retinal ganglion cell replacement in experimental glaucoma


NIH_SPENDING_CATS: Clinical Research;Wound Healing and Care

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The proposed studies focus on small extracellular vesicles secreted by wound macrophages in sites of injury that regulate stromal cells by suppressing the inflammation phase to promote re- epithelialization. We hypothesize that a mechanistic understanding of how small extracellular vesicles are formed, what contents are biologically active, and which cells uptake these vesicles is critical for the over-arching goal of developing extracellular vesicles that have therapeutic potential by promoting the resolution of inflammation and wound closure.

PI_NAMEs: ELICEIRI, BRIAN P (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Biogenesis;Biological;Biology;Biomedical Engineering;cell type;Cells;Engineering;Epithelial Cells;extracellular vesicles;Genetic;genetic approach;Goals;Immune;Impaired wound healing;Inflammation;Injury;Intercellular Communication Process;Knowledge;Macrophage;Mass Spectrum Analysis;Mediating;Mediator;Modeling;novel;Nucleic Acids;overexpression;Phase;programs;Proteins;re-epithelialization;Regulation;Resolution;Signal Transduction;Site;skin wound;Skin wound healing;Stromal Cells;Therapeutic;tissue repair;tool;uptake;Vesicle;wound;wound bed;wound closure;wound healing;Wound models

PROJECT_TITLE: Mechanisms of extracellular vesicle biogenesis that regulate wound healing


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ILLINOIS INSTITUTE OF TECHNOLOGY

ORG_STATE: IL

PHR: Transgender women are among the groups in the United States at highest risk for HIV, as well as hazardous substance misuse, due in part to elevations in three interrelated areas underpinned by stigma and lack of gender affirmation: internalized stigma, psychological distress, and healthcare avoidance. Acceptance and Commitment Therapy (ACT), which has been shown to reduce internalized stigma, psychological distress, and improve treatment engagement, may thus improve substance misuse and HIV risk. By employing a user-centered design approach to adapt, design, and test a peer-delivered gender affirming ACT intervention to improve substance misuse and HIV risk in transgender women, this K99/R00 proposal answers a compelling need for sustainable delivery of evidence-based programming in transgender-serving community-based organizations.

PI_NAMEs: GUY, ARRYN ALEIA (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;AIDS prevention;analytical method;Area;Attitude;Award;Behavior;behavior change;Behavior Therapy;Behavioral;behavioral health;behavioral response;career;Caring;Collaborations;Communities;community advisory board;community based participatory research;community engaged research;community organizations;community partnership;comparison intervention;consistent condom use;coping;Coping Skills;Data;design;Diagnostic;Distress;Educational workshop;Effectiveness;effectiveness testing;effectiveness/implementation trial;Epidemic;evidence base;Evidence based intervention;experience;Feedback;Feeling;flexibility;Focus Groups;follow-up;Foundations;Fright;Future;gender affirmation;Gender Identity;gender minority group;Goals;Hazardous Substances;Health;health inequalities;Health Personnel;Healthcare;high risk;High Risk Woman;HIV;HIV disparities;HIV risk;Human immunodeficiency virus test;Hybrids;improved;Individual;internalized stigma;Intervention;Interview;Learning;Life;Manuals;marginalized population;meetings;Mentors;Mentorship;Methods;mindfulness;model design;Modeling;Modification;Needs Assessment;Outcome;peer;Persons;Phase;physical assault;pilot test;pilot trial;Play;Policies;Population;Positioning Attribute;post intervention;Process;programs;Provider;psychologic;psychological distress;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;Research Personnel;Resources;Risk;Role;Running;scale up;Scholarship;Science;Self Care;Services;sex;sexual assault;sexual minority group;Shame;skills;social health determinants;Social isolation;social stigma;Source;Stigmatization;Strategic Planning;substance misuse;substance use;Substance Use Disorder;symposium;System;telehealth;Testing;Theoretical model;Therapeutic Intervention;therapy development;Thinking;Training;transgender;transgender women;transmission process;treatment as usual;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;usability;user centered design;Victimization;Violence;Woman;Work

PROJECT_TITLE: A Gender-Affirming Stigma Intervention to Improve Substance Misuse and HIV Risk among Transgender Women


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pediatric;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative: Using Bionano’s optical mapping technology we are taking a novel approach to understand the structure and organization of the 22q11.2 region deleted in 22q11.2DS and duplicated in 22q11.2 duplications, significant pediatric disorders. We will examine the prevalence and role of various inversion polymorphisms and copy number variants as risk factors for these and other genomic disorders of 22q11.2 in several populations (CEU, African and African Americans) including parent/ affected child trios of 22q11DS subjects. In order to continue carrying out this proposed research we need to purchase a Generation 2 Saphyr System from Bionano Genomics.

PI_NAMEs: EMANUEL, BEVERLY S (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 22q;22q11;22q11.2;Affect;African;African American;African American population;Alleles;Automobile Driving;cat eye syndrome;caucasian American;Characteristics;Child;Childhood;Chromosome 22;Chromosome Deletion;Chromosomes;Classification;cohort;Complex;Copy Number Polymorphism;Data;DiGeorge Syndrome;Disease;Dissection;DNA;DNA Sequence;Ethnic Origin;Etiology;Event;Family;Fostering;Frequencies;Funding;Gene Rearrangement;General Population;Generations;Genetic Polymorphism;Genetic Recombination;Genetic Structures;Genome;Genomic Segment;Genomics;Germ Lines;Goals;Haplotypes;homologous recombination;Hospitals;human disease;Human Genome;Individual;innovation;insight;Lead;Live Birth;Maps;Mediating;Meiosis;microdeletion;Molecular;nanochannel;neuropsychiatry;novel;novel strategies;offspring;Optics;Parents;Pathology;Patients;Phase;Phenotype;Play;Population;Positioning Attribute;Prevalence;proband;Production;Recurrence;Research;Risk Factors;Role;segregation;single molecule;Site;Structural defect;Structure;Suggestion;Syndrome;System;Technology;Testing;Variant;whole genome;Work

PROJECT_TITLE: Molecular Dissection of the 22q11.2 Deletion Syndrome

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative We seek to develop new transition metal-catalyzed methods that are general, user-friendly, and have a significant impact on the field of organic synthesis, particularly in pharmaceutical research. Our current work is focused on palladium and copper-catalyzed coupling methods for the formation of carbon-carbon and carbon-heteroatom bonds. We specialize in creating highly functionalized molecules reliably and our techniques are widely adopted in academia and industry for synthesizing complex compounds. Our research heavily relies on analytical instruments, notably the GCMS. The GCMS plays a pivotal role in analyzing reaction mixtures, monitoring progress and elucidating mechanisms. Our current GCMS system has become outdated and in need of extensive repairs, necessitating a replacement. A new GCMS system will enhance the efficiency and reliability of our research, facilitating our work in the development of new reaction methodology.

PI_NAMEs: BUCHWALD, STEPHEN L (contact)

PROJECT_TERMS: Academia;Address;Administrative Supplement;Adopted;Agrochemicals;Air;Alcohols;Alkenes;Alkynes;Amination;Amines;analytical tool;Aniline;Area;base;Bibliography;Bromides;Carbon;catalyst;Charge;Complex;Consumption;Contract Services;Copper;cost;Coupling;Data;Dedications;design;Development;Diamines;drug discovery;Ensure;Equipment;Funding;Gas Chromatography;Gases;High Pressure Liquid Chromatography;Industry;infrared spectroscopy;insight;instrument;invention;Isotope Labeling;Kinetics;Ligands;Longevity;Magnetism;Maintenance;Manufacturer;Mass Fragmentography;Mass Spectrum Analysis;Metals;method development;Methodology;Methods;Modeling;Monitor;Natural Products;Needles;Nitrogen;novel;Nuclear;operation;Organic Synthesis;outcome prediction;Oxygen;Palladium;parent grant;Pathway interactions;Performance;Persons;Pharmacologic Substance;Play;Process;Property;Protocols documentation;Publications;rational design;Reaction;Reaction Time;Recurrence;repaired;Reporting;Research;Research Activity;research and development;Research Personnel;Role;Sampling;scale up;sensor;Services;Side;side effect;Solvents;Spectrum Analysis;Supercritical Fluid Chromatography;Syringes;System;Techniques;Temperature;Time;tool;Toxic effect;Training;Transition Elements;user-friendly;Vial device;Volatilization;Work

PROJECT_TITLE: Administrative Supplement for Equipment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Telehealth;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: ELKRIDGE

ORG_NAME: EVON MEDICS, LLC

PHR: NARRATIVE Longstanding neuroscience evidence is consistent that olfactory, other sensory, sensorimotor, and motor impairments often precede cognitive impairments in AD, thereby presenting an alternative strategy for detection of people at risk of progressive cognitive decline. The small business, Evon Medics created a prototype called EMRAST (Evon Medics Rapid Smell Test for AD), to perform culture- and language- independent smell tests for AD screening. This project will further product development to allow the: (1) incorporation of physiological monitoring and motor processing sensors and a sniff magnitude test, which we recently showed to signal an irreversible phase of AD progression when impaired; (2) development of machine learning/Artificial Intelligence algorithms to compute the EMRAST metrics into prediction of AD; (3) optimization of size, cost reductions, test functionality, durability, and hardware complexity for large-scale manufacturing; (4) demonstration of clinical validity in large samples; and (5) advancement of regulatory pathway to lead to adoption of optimized EMRAST (i.e., EMRAST-Extended) for clinical and community screening and prediction of AD progression.

PI_NAMEs: NWAOKOBIA, CHARLES CHIEDU (contact);NWULIA, EVARISTUS A;REDDY, VAMSI

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Adopted;Adoption;Age;age related;Age-associated memory impairment;Algorithms;Alzheimer's disease related dementia;Alzheimer's disease test;Anxiety;artificial intelligence algorithm;Businesses;Classification;classification algorithm;Clinical;clinical practice;Clinical Research;Cloud Computing;Cognition;Cognitive;Cognitive aging;cognitive task;Collaborations;Communities;comorbidity;cost;cost effectiveness;data communication;Dementia;Detection;Development;Devices;Diagnosis;digital;Disease;Early Diagnosis;Early identification;early screening;Education;Elderly;Evaluation;experience;Family member;Feedback;finger movement;Fingers;follow-up;Goals;Grant;health determinants;Health Insurance Portability and Accountability Act;Health Personnel;Home;Impaired cognition;Impairment;Incentives;Individual;Infrastructure;International;Intervention;Language;large scale production;Machine Learning;Marketing;Measurement;Measures;Memory;mild cognitive impairment;mobile application;Motor;motor disorder;motor impairment;Neurodegenerative Disorders;Neurologist;Neurosciences;normal aging;novel;Odors;older patient;Olfactory dysfunction;Pathologic;patient population;Persons;Phase;phase 2 study;Physicians;Physiologic Monitoring;Physiological;pilot test;Population;Populations at Risk;portability;pre-clinical;Predisposition;primary care provider;Process;product development;prognostic value;prognostication;prototype;Provider;Psychophysics;Public Health;Reflex action;Regulatory Pathway;remote monitoring;Research;research clinical testing;Research Personnel;Risk;Sampling;satisfaction;Science;screening;Self Efficacy;sensor;Sensorimotor functions;Sensory;Sensory impairment;Services;Severities;Signal Transduction;Small Business Innovation Research Grant;Smell Perception;smell test;Specificity;Staging;success;Surveys;Symptoms;Testing;tool;Universities;Use Effectiveness;user-friendly;Validation

PROJECT_TITLE: Development and Evaluation of Portable Compendium of Psychophysical and Physiological Tests for Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-M(12)B]


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The Exon Junction Complex (EJC) and Nonsense-Mediated mRNA Decay (NMD) components lie at the heart of a eukaryotic mRNA surveillance mechanism that monitors ribosomes during translation to suppress genetic errors and regulate normal gene expression. To answer the long-standing question of how these mRNA surveillance machineries engage with the ribosome, we have identified mutations that arrest the key NMD components on the ribosomes. The Biocomp gradient fractionation system requested here will be used to purify these ribosome-associated surveillance complexes to determine their genome-wide locations and protein composition, thereby advancing the project proposed in the parent grant.

PI_NAMEs: SINGH, GURAMRIT  (contact)

PROJECT_TERMS: Adaptor Signaling Protein;Animals;Anti-viral Response;Award;Binding;Biochemical;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Complex;Defect;Development;Embryo;equipment acquisition;Eukaryota;Exons;fitness;Fractionation;Gene Expression;Genetic;Genetic Processes;genome-wide;Genomics;Germ Cells;Goals;Health;Heart;Human;in vivo;Intellectual functioning disability;Knowledge;Location;Mediating;Mental Retardation;Messenger RNA;Modeling;Molecular;Monitor;motor neuron development;mRNA Decay;mRNA Surveillance;Muscle Development;mutant;Mutation;neurogenesis;Nonsense Mutation;Organism;paralogous gene;parent grant;parent project;Parents;Pathway interactions;Post-Transcriptional Regulation;posttranscriptional;premature;Process;programs;Proteins;Recycling;Regulation;Research;Ribosomes;RNA;Role;Shapes;Signal Transduction;Site;stem cells;System;Technology;Therapeutic;Translations;United States National Institutes of Health;Variant;Work;Zebrafish

PROJECT_TITLE: Post-transcriptional gene regulation by the exon junction complex


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The goal of this supplement project is to use a 3D ex vivo ovarian follicle culture model to study the female reproductive toxicity and molecular mechanisms of real-world surface river water organic matter extracts. These studies are critically important to reveal novel insight into chemical mixtures-induced ovarian toxicity and prioritize chemicals of high ovotoxicity concern and for further risk assessment for protecting women’s reproductive health.

PI_NAMEs: XIAO, SHUO  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: 3-Dimensional;Acceleration;aged;Animals;Architecture;Biological Assay;Chemicals;consumer product;cost;Development;environmental chemical;Fertilization;girls;Goals;Gonadal Steroid Hormones;Growing Follicle;Growth;harmful algal blooms;Hormone imbalance;Hormone secretion;Human;Image;In Vitro;Infertility;innovation;insight;Liver;liver metabolism;Luteinization;Menstrual cycle;Microfluidics;Modeling;Molecular;Morphology;novel;oocyte maturation;Oocytes;Ovarian;Ovarian Follicle;Ovary;ovotoxicity;Ovulation;parent grant;peptide hormone;Pharmacologic Substance;Premature Ovarian Failure;prepuberty;Primordial Follicle;reproductive;reproductive outcome;reproductive toxicity;Research;Risk;Risk Assessment;screening;Surface;Testing;Toxic effect;Toxic Environmental Substances;Toxin;Transgenic Mice;Translating;validation studies;Water;Woman;women's reproductive health;Women's study

PROJECT_TITLE: Diversity Supplement to An ovary-on-a-chip to identify ovarian toxicity

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

ORG_STATE: MA

PHR: Narrative The goal of this research effort is to develop novel and versatile computational methods for deriving quantitative understanding of the molecular basis of disordered proteins and dynamic interactions in biomedically important processes. Through strategic experimental collaborations, new insights will be generated for addressing fundamental and biomedical questions related to signaling, cancer, protein misfolding, protein aggregation and innate immunity. 2

PI_NAMEs: CHEN, JIANHAN  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Address;Antineoplastic Agents;Area;Biological;Biology;Biomedical Research;Cells;Collaborations;Complex;Computing Methodologies;coping;Decision Making;Development;Diabetes Mellitus;Disease;Epigallocatechin Gallate;Family;Feedback;Flavivirus;Goals;Heart Diseases;Human;human disease;Immune;insight;Length;Malignant Neoplasms;Measurement;Mediating;Methodology;Methods;models and simulation;Molecular;Molecular Chaperones;Molecular Conformation;molecular modeling;Mutation;Names;Natural Immunity;Neurodegenerative Disorders;novel;Peptide Hydrolases;Peroxidases;Pharmaceutical Preparations;Phosphorylation Site;Play;Prevalence;Process;Property;protein aggregation;Protein Dynamics;protein folding;protein function;protein misfolding;protein protein interaction;protein structure function;Proteins;Research;Role;Signal Transduction;simulation;Staphylococcus aureus;Structure;System;Testing;Therapeutic;Time;TP53 gene;Transactivation;virtual;Virulence

PROJECT_TITLE: Disordered Proteins and Dynamic Interactions in Biology and Diseases


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: DNA recombination is essential for chromosome stability, for antibody diversification, for gene targeting that has broad application in the medical field, and is highly relevant to many human disorders, cancer, and aging. This project will address fundamental questions about the mechanism and control of recombination, focusing on the formation of the initial recombination intermediate, single-stranded DNA.

PI_NAMEs: IRA, GRZEGORZ A (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aging;Antibodies;Biological Assay;Cell Cycle;Cells;Chromatin;Chromosomal Breaks;Chromosomal Stability;Complex;design;Disease;DNA;DNA Double Strand Break;Double Strand Break Repair;Euchromatin;Excision;Fission Yeast;Gene Targeting;Genetic Recombination;Genetic Transcription;Genome Stability;Goals;helicase;Heterochromatin;homologous recombination;Human;Malignant Neoplasms;Mediating;Medical;Minor;model organism;Nonhomologous DNA End Joining;nuclease;Pathway interactions;Process;Proteins;RAD52 gene;Regulation;repaired;response;Role;Single-Stranded DNA;System;Yeasts

PROJECT_TITLE: Regulation of Initial Steps of Chromosomal Breaks Repair


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chromatin replication is a complex cellular process that requires multiple regulatory mechanisms to maintain genomic and epigenomic stability. The histone H3.1-TSK/TONSL pathway plays a major role in resolving stalled or broken replication forks via homologous recombination. We will further characterize the role of H3.1- TSK/TONSL in regulating DNA repair and genome stability, and define new functions for this conserved pathway during replication.

PI_NAMEs: JACOB, YANNICK  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Cell Physiology;Chromatin;Complex;daughter cell;Development;DNA biosynthesis;DNA Methylation;DNA Repair;DNA replication fork;Epigenetic Process;epigenomics;Eukaryota;Genetic;Genetic Transcription;Genome;Genome Stability;Genomics;Goals;Health;Histone H3;histone modification;Histones;homologous recombination;Human;human disease;Information Protection;interest;Maintenance;Malignant Neoplasms;Mediating;Molecular;Mutation;Neurodegenerative Disorders;novel;Organism;Pathway interactions;Play;prevent;Process;Proteins;Research;Role;Tertiary Protein Structure;transmission process;Variant;Work

PROJECT_TITLE: Investigating the roles of the H3.1-TSK/TONSL pathway during chromatin replication


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Prevention

ORG_NAME: NEW YORK UNIVERSITY

PHR: Mitochondrial permeability transition is stress-induced damage to the mitochondrial inner membrane that disrupts mitochondrial function and leads to cell death. Our proposal aims to investigate molecular mechanisms underlying permeability transition. This knowledge will help to understand one of the central pathological events that cause damage during the stroke and heart attack.

PI_NAMEs: PAVLOV, EVGENY  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Animal Diseases;Award;Biological Assay;Calcium;Cell Death;Cell Membrane Permeability;Cells;Cessation of life;Complex;Coupled;Disease;Drug Targeting;electrical potential;Electrophysiology (science);Energy-Generating Resources;Ensure;Eukaryotic Cell;Event;Functional disorder;Generations;Goals;Homeostasis;Inner mitochondrial membrane;Knowledge;Link;Measurement;Measures;Membrane Potentials;Methods;Mitochondria;mitochondrial membrane;Modeling;Molecular;Myocardial Infarction;Nerve Degeneration;oxidation;Oxidative Phosphorylation;patch clamp;Pathologic;Pathway interactions;Permeability;Phosphorylation;Potential Energy;prevent;Prevention;Process;programs;Regulation;Research;Respiratory Chain;Severities;Stress;Stroke;Therapeutic;therapeutic development;Tissues

PROJECT_TITLE: Molecular mechanisms of the mitochondrial permeability transition


PHR: Narrative Little is known on the regulatory pathways mediating transgenerational epigenetic inheritance. Our results provide genetic evidence for a novel pathway in mice that regulates high fat diet response in the next generation and that is governed by the E3 ligase Rlim in paternal testicular Sertoli cells. Investigating this Sertoli cell --> sperm --> offspring pathway, our research will uncover novel epigenetic mechanisms and establish our conditional Rlim KO mice as a new paradigm for transgenerational epigenetic regulation.

PI_NAMEs: BACH, INGOLF M (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Ablation;Adult;Affect;Alleles;Biological;Biological Models;blastocyst;cell type;Diet;diet-induced obesity;DNA Methylation;Dosage Compensation (Genetics);Embryo;Energy Metabolism;Epigenetic Process;epigenetic regulation;epigenetic silencing;Fathers;Female;Genes;Genetic;Genetic Models;Germ Cells;Goals;High Fat Diet;histone modification;imprint;Investigation;Knockout Mice;Link;male;Mediating;Microscope;Molecular;mouse model;Mus;next generation;novel;offspring;Pathway interactions;Publishing;Regulatory Pathway;Research;response;Ring Finger Domain;sertoli cell;Signal Transduction;Small RNA;sperm cell;Spermatids;Spermatogenesis;Spermatogenic Cell;Technology;Testis;transgenerational epigenetic inheritance;transmission process;ubiquitin-protein ligase;X Chromosome;X Inactivation

PROJECT_TITLE: Microscope


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: The repair of DNA double-strand breaks (DSBs) is essential to maintain genome integrity and to guard against cancer in humans. We will use the yeast Saccharomyces cerevisiae model system to address the mechanisms of DSB repair; specifically, we will determine how repair proteins interacts with chromatin remodeling complexes to process DSB ends, and define the roles of the Mre11 complex and nucleosome assembly factors in repair of collapsed replication forks. In the long term we believe that mechanisms under investigation in this proposal will provide new insight and fundamental knowledge for understanding disease caused by genomic instability.

PI_NAMEs: SYMINGTON, LORRAINE S (contact)

PROJECT_TERMS: Address;Biological Models;Cell Survival;Cells;Cellular Metabolic Process;Chemotherapy and/or radiation;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosomal Breaks;chromosome loss;Complex;Coupled;cytotoxic;Defect;Development;Disease;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Gene;DNA replication fork;Double Strand Break Repair;Endonuclease I;Event;Excision;Genetic Recombination;genome integrity;Genomic Instability;Goals;homologous recombination;Human;Immunologics;insight;Investigation;Knowledge;Lesion;Malignant Neoplasms;Methodology;Micrococcal nuclease digestion of chromatin followed by sequencing;Neurologic;Normal Cell;novel;novel therapeutics;Nucleosomes;Pathway interactions;practical application;Predisposition;Process;programs;Proteins;Regulation;repaired;replication stress;Research;Resistance;Role;Saccharomyces cerevisiae;Sister Chromatid;Site;System;targeted treatment;Toxic effect;Yeasts

PROJECT_TITLE: Mechanism and regulation of DNA double-strand break repair


ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

PHR: NARRATIVE DNA nanostructures have promise in biomedical applications such as biosensing, drug delivery and bioimaging, but the field faces several challenges for it to be used in practical applications. In addressing these challenges, I propose to develop robust, multifunctional drug delivery platform for treating multisystemic diseases and design self-assembled 3D DNA crystals as scaffolds for X-ray structure determination using the new technique of Serial Femtosecond X-ray Crystallography. In the long-term, I envision that our modular, platform technology using DNA nanostructures can be adopted by other labs for different disease treatments and drug screening and to obtain crystallographic information of hard-to-crystallize molecules.

PI_NAMEs: CHANDRASEKARAN, ARUN RICHARD  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Antibodies;Area;Award;Binding;Biodistribution;bioimaging;Biological;Biological Availability;Biosensing Techniques;Body System;Cell Culture Techniques;Cells;Chemicals;Crystallization;Crystallography;Data;design;design and construction;Development;Disease;DNA;drug candidate;Drug Carriers;Drug Delivery Systems;Drug Screening;Face;fluorophore;Freezing;Health;Immune response;improved;Ligands;Methods;Minor Groove;Modification;mouse model;Myotonic dystrophy type 1;nanoparticle;Nanostructures;Nanotechnology;National Institute of General Medical Sciences;Oligonucleotides;Peptides;Pharmaceutical Preparations;Polycyclic Compounds;Positioning Attribute;practical application;pre-clinical;Proteins;Radiation induced damage;Research;Research Personnel;Resolution;Roentgen Rays;scaffold;Scaffolding Protein;screening;self assembly;Structure;Systemic disease;technology platform;Toxic effect;Use of New Techniques;Validation;Work;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: Programmable DNA Nanostructures as Biomedical and Structural Scaffolds

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE This longitudinal observational study examines multiple levels of Structural Racism and Discrimination (SRD) including individual (both intrapersonal and interpersonal), neighborhood, institutional, and societal/policy and their associations with mental, physical, and behavioral health outcomes across the life course. Innovative mixed-methods (e.g., ecological momentary assessment, geographic information system data, community- based participatory approaches, biomarkers) are being used at two sites (Minnesota, Georgia), across two time points 18 months apart, with families from racially/ethnically and socioeconomically diverse households (n=927). Study findings will identify targets for intervening at multiple SRD levels to promote health equity.

PI_NAMEs: BERGE, JERICA M;FERTIG, ANGELA RICE (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: Adolescence;Adult;African American;behavioral health;Biological;Biological Markers;Blood Pressure;Cardiometabolic Disease;cardiometabolism;Childhood;Clinical Trials;community based participatory approach;cytokine;Data;design;Discrimination;Ecological momentary assessment;Elements;ethnic diversity;Ethnic Origin;Family;Geographic Information Systems;Glycosylated hemoglobin A;Health;health disparity;health equity;health equity promotion;Heart Rate;Hispanic;Household;Immigrant;Individual;innovation;Institution;Institutional Racism;Intervention;Life Cycle Stages;Lipids;Longitudinal cohort study;Longitudinal Studies;Longitudinal, observational study;Measures;Mental Depression;Mental Health;Methods;Minnesota;Native Americans;Neighborhoods;Outcome;Outcome Measure;Parents;Participant;perceived discrimination;Persons;physical conditioning;Policies;prospective;Psyche structure;Public Health;Race;racial diversity;racism;Refugees;Research;Research Design;Rural;rural families;rural setting;Sampling;segregation;Site;socioeconomics;Source;Stress;Structural Racism;Surveys;therapy development;Time;urban setting;waist circumference;Well in self

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp - Clinical Trial Not Allowed)


NIH_SPENDING_CATS: Aging;Biotechnology

ORG_CITY: ANN ARBOR

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: The proposed work will generate first-in-class small molecule inhibitors of the PAPP-A protease, which will be useful chemical tools to explore the biology of IGF1 signaling, and serve as promising candidate anti-aging compounds. Mice lacking PAPP-A show extended lifespan and protection from diverse age- associated diseases. The proposed work is therefore relevant to NIA’s mission to support biological research on aging, and to NIH’s larger mission to foster research to protect and improve health.

PI_NAMEs: LOMBARD, DAVID BENNER;NIKOLOVSKA-COLESKA, ZANETA  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Ablation;Address;Adipose tissue;Adult;Age related pathologies;age-related disease;Aging;analog;anti aging;Antibodies;Area;Atherosclerosis;Binding;Biochemical;Biological Assay;Biological Availability;biological research;Biology;biomarker identification;Biophysics;Cardiomyopathies;Cell Culture Techniques;Cell surface;Cells;Chemicals;Chronic;Chronic Disease;comparison control;Complex;Cultured Cells;Data;Dependence;design;Development;Diet;Disease;Drug Design;effective therapy;Enzyme Inhibition;enzyme mechanism;extend lifespan;Fibroblasts;Fluorescence;Fostering;Future;Gene Expression;Genes;Genetic Transcription;Germ Lines;Goals;Health;high throughput screening;Homeostasis;Homologous Gene;Human;IGF1 gene;IGFBP4 gene;IGFBP5 gene;improved;In Vitro;in vivo;inhibitor;Insulin-Like Growth Factor Binding Protein 4;Insulin-Like Growth Factor Receptor;Insulin-Like Growth-Factor-Binding Proteins;Intervention;Kidney Diseases;Knockout Mice;Knowledge;Lead;life span;Ligands;Link;Longevity;loss of function;Macrophage;Malignant Neoplasms;Mammals;Measures;Mediator;Membrane;Metabolic;Metalloproteases;Mission;Mus;Mutation;Nerve Degeneration;novel;Oral;Pathogenicity;Pathology;Peptide Hydrolases;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Phase;Phenotype;Phosphorylation;Physiological;Polycystic Kidney Diseases;Pre-Clinical Model;Pregnancy-Associated Plasma Protein-A;Prevention;prohormone;Property;Proteins;Quantitative Reverse Transcriptase PCR;rate of aging;Reagent;Research;response;Risk Factors;Series;Signal Transduction;Skeletal Muscle;small molecule;small molecule inhibitor;Solubility;Somatotropin;Structure;Structure-Activity Relationship;Testing;Therapeutic;Thymus Gland;Time;Tissues;tool;transcriptome sequencing;United States National Institutes of Health;Validation;Western Blotting;Work

PROJECT_TITLE: Targeting the longevity regulator PAPP-A with small molecule inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-F(02)M]


ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Halide-containing nucleosides and nucleotides represent an important family of synthetic drugs for anticancer and antiviral treatments, thus it is essential to develop novel and effective synthetic strategies to expand halogenated nucleoside/nucleotide compound library for drug discovery. Radical halogenation via carbon- hydrogen bond activation catalyzed by iron and 2-oxoglutarate (Fe/2OG) dependent enzymes represents an attractive strategy to install carbon-halide bonds in a regio- and stereo-specific fashion. In this projects, two newly discovered Fe/2OG enzymes that catalyze radical halogenation to generate halide-containing nucleotide natural products and amino acids will be mechanistically investigated, the obtained mechanistic insights will be further deployed to develop these enzymes into biosynthetic platform to access new halide-containing nucleotide/nucelosides.

PI_NAMEs: GUO, YISONG  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Agrochemicals;alpha ketoglutarate;Amino Acids;Anions;Antineoplastic Agents;Architecture;Binding;Biomedical Engineering;Carbon;Carrier Proteins;chemical synthesis;Chemicals;chlorination;Consensus;design;drug discovery;electronic structure;Enzyme Kinetics;enzyme mechanism;Enzymes;Family;Foundations;Future;halogenation;Halogens;Hydrogen Bonding;Hydroxyl Radical;Hydroxylation;insight;interest;Iron;Knowledge;Libraries;Methodology;Modernization;molecular dynamics;Mononuclear;Natural Products;novel;Nucleosides;Nucleotide Biosynthesis;Nucleotides;Pharmacologic Substance;Proteins;Reaction;Research;Substrate Interaction;synthetic drug;Testing;Viral

PROJECT_TITLE: Dissect Mechanism of Iron(II)/2-Oxoglutarate Dependent Enzymes Catalyzed Halogenation in Nucleotide Biosynthesis


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Roles of ribonucleic acids (RNAs) for diverse functions in cellular processes continue to be discovered, calling for sophisticated approaches to investigate these central molecules in living cells. My research group has recently pioneered fluorescence lifetime imaging microscopy (FLIM) as an advantageous modality to visualize RNAs in live mammalian cells and live whole organisms, and demonstrated that FLIM offers the capability to visualize and track RNAs with multiplexing capabilities. The requested FLIM upgrade of an existing confocal microscope will allow us to advance these research goals.

PI_NAMEs: BRASELMANN, ESTHER  (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Alternative Splicing;Biological;Biological Models;Cell model;Cell Nucleus;Cell Physiology;Cells;Complex;Confocal Microscopy;Cues;Disease;DNA Sequence Alteration;environmental stressor;fluorescence lifetime imaging;Fluorescence Microscopy;Goals;Health;Home;imaging capabilities;imaging modality;interest;Introns;Joining Exons;Label;Link;Malignant Neoplasms;Mammalian Cell;Messenger RNA;Microscope;Modality;Nervous System Disorder;Pattern;Play;Process;programs;Proteins;Regulation;Request for Applications;Research;Research Personnel;RNA;RNA Splicing;Role;spatiotemporal;Spliceosomes;System;Technology;Time;Untranslated RNA;Visualization;Whole Organism;Work

PROJECT_TITLE: Illuminating multiplexed RNA dynamics to interrogate splicing in health and disease


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ATLANTA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: National Initiative on Gender, Culture and Leadership in Medicine: C-Change Project Narrative The FIRST CEC is requesting support for research/analyses that are within the original scope of an active NIH research grant U24MD017138-03. FIRST Program awardees are required to evaluate site-level institutional culture change as described in RFA-RM-22-008.

PI_NAMEs: OFILI, ELIZABETH O. (contact);RIVERS, BRIAN M.

PROGRAM_OFFICER_NAME: ROUSSOS, GINA PATIENCE

PROJECT_TERMS: Academic Medical Centers;Administrative Supplement;Alabama;anti-racism;Baltimore;California;cohort;County;Data;Data Collection;Data Set;Dimensions;Equity;Evaluation;experience;Faculty;Feedback;Feeling;Florida;Gender;Health Sciences;Institution;instrument;Leadership;Maryland;Measures;medical schools;Medicine;Mentors;New Mexico;Organizational Culture;Perception;Program Evaluation;programs;Research;Research Project Grants;Research Support;Respondent;Site;skills;South Carolina;Surveys;Teacher Professional Development;Texas;Trust;United States National Institutes of Health;Universities

PROJECT_TITLE: FIRST Coordination and Evaluation Center to promote inclusive excellence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(52)-R]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: STRATFORD

ORG_NAME: ROWAN UNIVERSITY SCHOOL/OSTEOPATHIC MED

PHR: Project Narrative DNA is constantly damaged in cells and must be repaired to maintain cellular health. This application examines protein complexes that form during a DNA repair process called uracil base excision repair. Uracil base excision repair regulates several biological processes including adaptive immunity, the infectivity of certain viruses, and the efficacy of specific chemotherapeutics.

PI_NAMEs: WEISER, BRIAN PATRICK (contact)

PROJECT_TERMS: adaptive immunity;Administrative Supplement;Architecture;Area;base;Base Excision Repairs;Binding;Biochemical;Biological Assay;Biological Process;Cell Nucleus;Cells;chemotherapeutic agent;Colorectal;Complex;CRISPR/Cas technology;crosslink;Data;design;Development;Dissociation;DNA;DNA Binding;DNA biosynthesis;DNA Maintenance;DNA Repair;DNA replication fork;DNA Structure;ds-DNA;Engineering;Escherichia coli;Excision;experimental study;Genetic Recombination;Health;HT29 Cells;Human;In Vitro;in vivo;Individual;interest;Knock-out;Ligation;Methodology;Methods;Modeling;Molecular;Multiprotein Complexes;mutant;Nature;Nuclear;Pathway interactions;Process;Proliferating Cell Nuclear Antigen;protein complex;Protein Engineering;protein function;protein purification;Proteins;Proteomics;Reaction;Recombinants;Repair Complex;repaired;replication factor A;Replication-Associated Process;Role;scaffold;Single-Stranded DNA;Site;Stress;Structure;success;Surface;synthetic construct;System;Telomere Maintenance;Testing;Therapeutic;Uracil;uracil-DNA glycosylase;Virus

PROJECT_TITLE: RPA-Directed DNA Repair Mechanisms - Administrative Supplement II


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Chromosomes must accurately segregate in order for organisms to develop and survive. Chromosome segregation errors lead to aneuploidy that drives cancer and genetic disease. Our proposed studies address the mechanisms that ensure proper chromosome segregation to avoid cancer and genetic disease associated aneuploidy.

PI_NAMEs: STRAIGHT, AARON F (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Aneuploidy;Binding Proteins;Binding Sites;Cell Cycle;Cell division;Cell Division Process;Cells;Centromere;centromere protein A;centromere protein C;Chromatin;chromosome missegregation;chromosome movement;Chromosome Segregation;Chromosomes;Complement;Complex;Coupling;Defect;density;Down's Syndrome;Ensure;Genetic Diseases;Genome;Histone H3;Histones;HMGN Proteins;Human;Human Genetics;Kinetochores;Lead;Maintenance;Malignant Neoplasms;Maps;Methods;Methylation;Microtubules;Mitotic spindle;Natural regeneration;Nucleosomes;Organism;Physical condensation;Positioning Attribute;Property;Proteins;Resistance;Role;segregation;Site;Testing;Variant;Vertebrates;Work

PROJECT_TITLE: Mechanisms of Kinetochore Assembly