NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Disability Research;Physical Activity;Sarcopenia

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative This K25 application seeks support for career development that will allow the PI to gain expertise in development, validation, and clinical implementation of a new type of magnetic resonance imaging methodology that can be used to quantify microvascular changes as well as the accumulation of macromolecules in tissue that occur with aging. The PI will also undertake didactic and professional training to allow her to become an independent investigator applying novel imaging biomarkers to the study of degenerative changes in skeletal muscle tissue with aging.

PI_NAMEs: ADELNIA, FATEMEH  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 3-Dimensional;Adult;Age;age group;age related;age related chronic disease;Aging;Anatomy;Animal Model;animal old age;Animals;Biological;Biological Markers;Biology of Aging;Blood capillaries;Blood Vessels;Blood Volume;Capillarity;career;career development;Cells;Characteristics;Chronic Disease;Clinical;clinical application;clinical implementation;Clinical Research;cohort;Collagen;Data;data acquisition;Data Analyses;Deposition;Deterioration;Development;diffusion weighted;digital pathology;disability;Elderly;Environment;Etiology;experience;Extracellular Matrix;Fatty acid glycerol esters;Fibrosis;Foundations;frailty;Functional impairment;Goals;hemodynamics;Histologic;Histology;Human;human subject;Image;imaging biomarker;imaging modality;imaging science;imaging study;Imaging Techniques;Impairment;improved;Inbred F344 Rats;indexing;innovation;Institution;interest;juvenile animal;K-Series Research Career Programs;Knowledge;macromolecule;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Mass Spectrum Analysis;Measurement;Measures;Membrane;Mentorship;Metabolic;Methodology;Methods;microvascular pathology;middle age;mitochondrial dysfunction;Muscle;muscle aging;Muscle Contraction;Muscle Fibers;Muscular Atrophy;Noise;novel;Nutrient;Oxygen;parametric imaging;Pathologic;Pathology;Patient Self-Report;Physical activity;Process;programs;protein distribution;Protocols documentation;quadriceps muscle;Relaxation;Reporting;Research;Research Personnel;Resolution;Rest;Rodent Model;Role;Rotation;sarcopenia;Scanning;Signal Transduction;simulation;Skeletal Muscle;soft tissue;Structure;Surrogate Markers;Techniques;Therapeutic;Thigh structure;Time;time interval;tissue degeneration;Tissues;tool;Training;Translating;translational applications;Universities;Validation;Variant;walking speed;Water

PROJECT_TITLE: Development and Application of T1rho Dispersion Imaging of Aging Muscle

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Genetics;Hematology;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Blood flow is essential for the production of hematopoietic stem cells (HSCs) during embryonic development; successful harnessing of the regulatory program initiated or maintained by this extrinsic regulatory factor may facilitate growth and expansion of HSCs for therapeutic use. I propose to use zebrafish as an in vivo platform to dissect the physical, cellular and molecular mechanisms by which hemodynamic forces intersect with YAP transcriptional regulation to drive HSC production. Translation of this work to in vitro human hematopoietic differentiation has potential to facilitate generation of clinically useful HSCs for the treatment of blood diseases.

PI_NAMEs: SUGDEN, WADE WILLIAM (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Achievement;Address;Adult;Advisory Committees;Algorithms;Animals;Aorta;Arteries;Award;Behavior;Blood;Blood Cells;Blood flow;blood treatment;Blood Vessels;Boston;Candidate Disease Gene;career development;Cell Nucleus;cell type;Cells;Cellular biology;Chemicals;Circulation;Cleavage Under Targets and Release Using Nuclease;Clinical;cofactor;Complex;Coupled;Coupling;Cues;Data;Dedications;Development;developmental genetics;directed differentiation;Distant;DNA;DNA Binding;DNA-Protein Interaction;Dorsal;Embryo;Embryonic Development;Endothelial Cells;endothelial stem cell;Endothelium;Enhancers;Environment;Erythroid;Event;Exhibits;Fetal Liver;Fishes;Future;Gene Expression;Generations;Genes;Genetic;genetic manipulation;Genetic Transcription;genome-wide;Goals;Growth;Growth and Development function;Hematological Disease;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic Cell Production;hematopoietic differentiation;hematopoietic gene;Hematopoietic Neoplasms;hematopoietic stem cell differentiation;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell formation;Hematopoietic Stem Cell Specification;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;hematopoietic tissue;hemodynamics;hemogenic endothelium;Home;Human;Image;Immune;improved;In Vitro;in vivo;in vivo evaluation;Individual;induced pluripotent stem cell;Integrins;interest;knock-down;Laboratories;large scale production;Learning;leukemia/lymphoma;Link;link protein;Logic;Lymphoid;Mammals;mechanical force;mechanical signal;Mechanical Stimulation;Mechanics;Mediating;Mediator;medical schools;Membrane;Membrane Proteins;Mentors;Mentorship;Methods;migration;Molecular;Morphogenesis;Morphology;Myelogenous;new technology;non-genetic;novel;Nuclear;Organism;Patients;Pediatric Hospitals;Periodicity;Phase;Phenotype;Piezo 1 ion channel;Piezo ion channels;Postdoctoral Fellow;Production;programs;protein activation;Protein Activation Pathway;Proteins;Protocols documentation;Regulation;Research;Research Training;response;RUNX1 gene;Scientist;self-renewal;shear stress;Signal Transduction;Signaling Protein;Solid;Sorting;Specific qualifier value;stem cell biology;Stem Cell Development;Stretching;success;System;Therapeutic;Therapeutic Uses;Tissues;Training;transcription factor;Transcriptional Regulation;transcriptomic profiling;transcriptomics;Translational Research;Translations;Transplantation;vertebrate embryos;Viscosity;Work;Zebrafish

PROJECT_TITLE: Mechanisms of Flow-driven Transcriptional Control of Hematopoietic Stem Cell Development by YAP


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative: Clonal hematopoiesis of indeterminant potential (CHIP) is thought to occur in >10% of individuals over the age of 70 and has been associated with an increased risk of hematologic malignancy and cardiovascular disease. At present, it is unclear which individuals with CHIP will progress to malignancy and how inflammation contributes to this process. The proposed research will assess the impact of CHIP-associated mutations on hematopoietic stem cell clonal output and immune cell development and differentiation with the goal of identifying relevant cells and pathways that may be clinically targeted to prevent or delay leukemic transformation.

PI_NAMEs: RUBIN, SARA ANN (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adult;Affect;Age;Animal Model;Anti-Inflammatory Agents;Atherosclerosis;B-Lymphocytes;Bar Codes;Blood Cells;Blood Platelets;cancer risk;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;Cell Separation;cell type;Cells;Chemicals;Clinical;Clinical Management;clinical practice;Clonal Expansion;Clonal Hematopoietic Stem Cell;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coronary heart disease;CRISPR/Cas technology;cytokine;Development;Dichloromethylene Diphosphonate;Disease;Disease Progression;DNA Sequence Alteration;Erythrocytes;Etiology;EZH2 gene;Fishes;Frequencies;Gene Expression Profile;Gene Expression Profiling;Generations;Genes;genetic manipulation;Genetic Transcription;genome editing;genomic locus;Goals;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterozygote;high risk;Human;Immune;in vivo;Individual;Inflammation;Inflammatory;insight;Kidney;knock-down;Knock-out;Knowledge;Lead;leukemic transformation;Life;Liposomes;Lymphocyte;Lymphoid;Lymphoid Cell;Macrophage;Malignant Neoplasms;Maps;Marrow;Mature Lymphocyte;Methods;Modeling;mosaic variant;mutant;Mutate;Mutation;Myelogenous;Myeloid Cells;neutrophil;novel;Nutrient;Organism;Orthologous Gene;Output;Pathway interactions;Patients;Play;Population;Population Heterogeneity;Precancerous Conditions;Prevalence;prevent;Prevention strategy;Process;Production;programs;Research;Risk;Role;RUNX1 gene;Sampling;Scientist;Secondary to;single cell analysis;single cell technology;single-cell RNA sequencing;Somatic Mutation;stem cell biology;Stem Cell Development;stem cell differentiation;stem cell expansion;stem cells;T cell clonality;T cell receptor repertoire sequencing;T-Lymphocyte;Technology;Testing;Thymus Gland;Time;tissue injury;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Single-Cell Profiling and Lineage Tracing of Zebrafish Hematopoiesis


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: Personalized medicine will greatly improve the effectiveness of cancer care. This study explores a unique personalized medicine opportunity for B cell hematologic malignancies by time-efficient and cost-effective generation of nucleic acid aptamers to target cell-based markers that are specific to the tumor and unique to the patient. These aptamers will be used to enable personalized disease monitoring and precision therapy, potentially initiating a transformative change in the care of patients with B cell hematologic malignancies.

PI_NAMEs: LIN, QIAO  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Affinity;Antibodies;aptamer;B lymphoid malignancy;B-Cell Antigen Receptor;B-Cell Lymphomas;B-Cell Neoplasm;B-Lymphocytes;Behavior;Binding;Biochemical;Biological;Blood specimen;cancer care;cancer cell;Cancer Diagnostics;Cell Line;Cell surface;Cells;Chronic Lymphocytic Leukemia;Classification;Clinical;clinical decision-making;cohort;Consumption;cost effective;COVID-19;cross reactivity;Detection of Minimal Residual Disease;Development;Diagnostic;Disease;Disease remission;DNA;Effectiveness;Evolution;Generations;Hematologic Neoplasms;Hour;Immunoglobulin Idiotypes;improved;In Vitro;innovation;Libraries;Ligands;Magic;Magnetic nanoparticles;Malignant - descriptor;Malignant Neoplasms;Mantle Cell Lymphoma;Methods;Microfluidics;Monitor;Monoclonal Antibodies;Multiple Myeloma;neoplastic cell;novel;Nucleic Acids;Oligonucleotides;Patient Care;Patients;peripheral blood;personalized medicine;personalized therapeutic;Precision therapeutics;Process;protein biomarkers;Proteins;Protocols documentation;Randomized;Reagent;Residual Neoplasm;response;Sampling;Specificity;Surface Immunoglobulins;targeted treatment;Technology;Therapeutic;Time;Translations;treatment strategy;tumor

PROJECT_TITLE: A Practical Approach to Tumor-Specific Aptamers for B-Cell Hematologic Malignancies


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE The Communities Actively Researching Exposure Study (CARES) is a successful and well-established environmental pediatric epidemiology cohort study that has reported the impact of environmental manganese exposure on pediatric brain function. This proposal will retain the over 600 child-parent pairs, enhance the robust dataset with ambient and internal exposure characterization during early childhood development, and build the infrastructure needed to share the unique data within the cohort.

PI_NAMEs: HAYNES, ERIN N (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Acceleration;Adolescent;Adult;Age;Air;Anatomy;Applications Grants;biobank;Biological;Biological Markers;Blood;Brain;Caregivers;Chemistry;Chicago;Child;Childhood;cohort;Cohort Studies;Collaborations;Communities;Community Developments;community engaged research;Data;data management;Data Management Resources;Data Set;data sharing;deciduous tooth;Development;Dust;early childhood;Environmental Epidemiology;Environmental Exposure;Environmental Health;Environmental Impact;Equipment and supply inventories;Etiology;Evaluation;Exposure to;Funding;Grant;Growth and Development function;Hair;Home;Illinois;improved;Infrastructure;innovation;Knowledge;Lab On A Chip;Laboratories;life span;Magnetic Resonance Imaging;Maintenance;Manganese;Measurement;Measures;Metals;Methods;Motor;National Institute of Environmental Health Sciences;Neuroanatomy;neurodevelopment;Neurodevelopmental Deficit;Neuropsychology;next generation;novel;Ohio;Outcome;Parents;Participant;participant retention;patient engagement;Pediatric cohort;Pediatric epidemiology;Physiology;Play;point of care;Police;Population;preservation;primary caregiver;Psychosocial Factor;Reporting;research study;Resources;Role;Saliva;Sampling;Scientific Advances and Accomplishments;Scientist;sensor;Serum;Side;Soil;Structure of nail of toe;Time;toxicant;Training;United States;Urine;Water;Whole Blood

PROJECT_TITLE: Retention, Maintenance and Enhancement of the Communities Actively Researching Exposure Study (CARES)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: NARRATIVE Social cognition is among the most complex and poorly understood aspects of human behavior. It is a core milestone in human ontogeny and broadly involves psychosocial conditions such as autism spectrum disorder, bipolar affective disorder and schizophrenia. Here, we aim to provide the first direct comprehensive single- neuronal, population-, time-causal and local network-based investigation of social cognition in the human prefrontal cortex.

PI_NAMEs: WILLIAMS, ZIV  (contact)

PROGRAM_OFFICER_NAME: GEBREHIWET, HERMON RUSSOM

PROJECT_TERMS: Acute;Address;Affect;Amygdaloid structure;Animal Model;Anterior;Area;autism spectrum disorder;Behavior;Behavioral;Belief;Bipolar Disorder;Brain;cingulate cortex;Cognitive;cognitive function;cognitive process;Communities;Complex;Computer Models;Data;design;Disease;Dissociation;Dorsal;Electrodes;Elements;Emotional;Evaluation;Event;experience;FDA approved;frontal lobe cortex;Goals;Growth;Hippocampus;Human;imaging study;Individual;innovation;insight;Institution;Institutional Review Boards;Investigation;Judgment;Lesion;Maps;memory process;Mental Depression;microstimulation;Modality;Network-based;neural;Neurons;novel;Participant;Pattern;Performance;Play;Population;Population Analysis;Prefrontal Cortex;Process;prospective;psychosocial;recruit;Research;Resolution;Role;Schizophrenia;Sensory;social;Social Behavior;social cognition;social neuroscience;Social Processes;Stroke;Structure;Techniques;Testing;theories;theory of mind;Time;Trauma;Work

PROJECT_TITLE: An Integrated Single-Neuronal, Population-, Local Network- and Stimulation-Based Prefrontal Investigation of Human Social Cognition


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Obesity

ORG_CITY: CORVALLIS

ORG_DEPT: BIOLOGY

ORG_NAME: OREGON STATE UNIVERSITY

ORG_STATE: OR

PHR: Nearly 90 million adults in the United States have prediabetes and limited options for effective therapeutic intervention. This project will provide new understanding of the therapeutic potential of using sodium-glucose cotransport 2 (SGLT2) inhibition as a treatment for prediabetes and generate new information regarding the mechanisms to explain how SGLT2 inhibition can improve skeletal muscle metabolism.

PI_NAMEs: NEWSOM, SEAN A. (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: 5'-AMP-activated protein kinase;Accounting;Address;Adult;adult obesity;Aftercare;Biological Models;Biopsy;Body Composition;Body Weight decreased;Cardiometabolic Disease;Cardiovascular system;Ceramides;Clinical Trials;clinically significant;comparison intervention;Data;Diglycerides;Disease;Disease Progression;Double-Blind Method;Excretory function;Fatty acid glycerol esters;Fatty Acids;feasibility testing;Glucose;Glucose Clamp;glucose disposal;glucose metabolism;Health;high risk;Human;human model;Hyperglycemia;Hyperinsulinism;improved;Individual;inhibitor;Insulin;Insulin Resistance;insulin signaling;Intervention;Kinetics;Life Style Modification;lipid metabolism;lipidomics;Lipids;Metabolic;Metabolic Diseases;metabolic phenotype;Metformin;Mission;Mitochondria;Modeling;Muscle Cells;Muscle Mitochondria;National Institute of Diabetes and Digestive and Kidney Diseases;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Overweight;oxidation;Participant;pilot test;Placebos;Prediabetes syndrome;Proteins;Randomized;Reporting;Respiration;response;Risk;Rodent Model;Role;Signal Transduction;Skeletal Muscle;skeletal muscle metabolism;Sodium;Stress;symporter;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Tracer;Treatment Efficacy;United States;urinary;Weight Gain

PROJECT_TITLE: Use of SGLT2 inhibition to improve skeletal muscle metabolism in prediabetes

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Violence Research

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Changes in cannabis and alcohol use, driven by cannabis legalization policies, may be important but underappreciated contributors to self-directed and interpersonal violence. We need to better understand how combinations of local cannabis and alcohol policies lead to high densities of both alcohol and cannabis outlets in low-socioeconomic status communities and resulting impacts on violence for community residents. This information is critical for local policymakers seeking to make informed decisions about regulating intoxicants in diverse communities.

PI_NAMEs: MATTHAY, ELLICOTT COLSON (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: Address;Affect;Alcohol consumption;alcohol effect;Alcohol Laws;alcohol outlet density;alcohol prevention;alcohol related consequences;Alcoholic Beverages;Alcohols;Algorithms;Area;assault;California;Cannabis;Cannabis policy;career;Categories;Cause of Death;Censuses;Cessation of life;Cities;City Government;Code;Communities;Community Health;community violence;County;County Government;Crime;Data Set;Databases;density;Depressive disorder;design;Disinhibition;Disparity;disparity reduction;Drug Controls;Drug usage;effectiveness evaluation;Emergency department visit;Epidemiologist;epidemiology study;Face;Feeling suicidal;Funding;Geography;Goals;Grant;Health;health data;Heterogeneity;Hospitalization;Individual;Injury;Inpatients;Interpersonal Violence;Joints;Knowledge;Laws;Lead;Legal;Licensing;Link;low socioeconomic status;marijuana legalization;marijuana use;Medical;Mentors;Mentorship;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Oranges;Outcome;outcome disparities;Pattern;Pharmaceutical Preparations;Play;Policies;Policy Maker;Population;population health;pressure;Prevention Research;Psychoses;public policy on alcohol;Quasi-experiment;Recreation;Reduce health disparities;Regulation;Reporting;Research;Research Training;Role;San Francisco;Self Direction;Self-Injurious Behavior;skills;social;Socioeconomic Status;Statistical Methods;substance use;Suicide attempt;Techniques;theories;Training;United States;Universities;Variant;Violence;violence prevention

PROJECT_TITLE: Joint Impacts of Local Alcohol and Cannabis Laws and Outlet Densities on Violence

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Orphan Drug;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative Over 300 different inherited mutations have been found in IKs channels that decrease the activity of IKs channels and cause a prolonged cardiac action potential (i.e. Long QT Syndrome), which can lead to cardiac arrhythmias in patients. We have identified a family of compounds that activate IKs channels, shorten the cardiac action potential, and are antiarrhythmic when applied to cardiomyocytes. We will here test variants of these compounds in order to develop a drug that will shorten the cardiac action potential to prevent cardiac arrhythmias and sudden cardiac deaths in Long QT Syndrome patients.

PI_NAMEs: BARRO-SORIA, RENE  (contact);DYKXHOORN, DEREK MICHAEL;LARSSON, HANS PETER;ODENING, KATJA ;TIELEMAN, PETER

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Action Potentials;Animal Model;Animals;Anti-Arrhythmia Agents;Aromatic Amino Acids;Arrhythmia;Binding;Binding Sites;Calcium Channel;Cardiac;Cardiac Myocytes;Cells;Cessation of life;Child;Clinical;Clinical Trials;Computer Simulation;Computers;Data;data modeling;Defect;Dependence;Development;efficacy testing;Electrocardiogram;Electrodes;Exhibits;experimental study;Family;functional restoration;Future;Heart;Human;human induced pluripotent stem cells;In Vitro;in vivo;Individual;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;Length;Long QT Syndrome;Membrane Potentials;Molecular;Molecular Mechanisms of Action;Movement;Mutation;novel;novel therapeutics;Oryctolagus cuniculus;Patients;personalized medicine;Pharmaceutical Preparations;Pharmacologic Substance;Polyunsaturated Fatty Acids;Potassium;Potassium Channel;preclinical study;prevent;Prevention;Property;Research Personnel;Risk Factors;sensor;simulation;Site-Directed Mutagenesis;Sodium Channel;Structure;sudden cardiac death;System;Techniques;Testing;Transgenic Animals;Transgenic Model;Transgenic Organisms;Variant;Ventricular;Ventricular Fibrillation;voltage;voltage clamp;young adult

PROJECT_TITLE: Polyunsaturated fatty acids as anti-arrhythmic agents.

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

PHR: PROJECT NARRATIVE Over 90% of pancreatic cancer patients die within 5 years of diagnosis because we currently lack effective treatments. We recently discovered a specific protein, Krüppel-like factor 5 (KLF5), is selectively essential for pancreatic cancer cell growth, and may therefore be a compelling target. In this project, we will combine innovative models and approaches to determine how KLF5 functions in pancreatic cancer and to evaluate if targeting KLF5 represents a promising therapeutic opportunity.

PI_NAMEs: CUNNIFF, PATRICK  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Acinar Cell;Acute;acute pancreatitis;Address;Adult;anti-cancer research;Binding;Biochemical;Biological Sciences;Biology;cancer cell;Cancer Cell Growth;cancer type;cell growth;Cell Proliferation;Cells;Chemoresistance;Chromatin;Clinical;Complementary DNA;Complex;Cytotoxic Chemotherapy;Data;Dependence;Development;Diagnosis;drug development;drug discovery;effective therapy;Environment;Epigenetic Process;epigenome;epigenomics;Epithelium;fitness;Gene Expression Regulation;Genes;Genetic Screening;Genetic study;Genetic Transcription;Genome;Goals;Growth;Homeostasis;Human;improved;In Vitro;Individual;Inflammation;innovation;Intestines;Investigation;Knowledge;KRAS oncogenesis;Laboratories;Link;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mentorship;Modeling;Molecular;mouse genetics;mouse model;multiple omics;Mus;Mutation;new therapeutic target;Oncogenic;Output;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic tumorigenesis;Pancreatitis;Patients;precursor cell;Process;Prognosis;protein protein interaction;Proteins;Regenerative capacity;Reporter;Research;Resources;Role;Schools;Serpins;Shapes;skills;standard of care;stem cell self renewal;stem cells;Survival Rate;targeted treatment;Therapeutic;Therapeutic Index;therapeutic target;Tissues;Training Programs;Transcription Coactivator;transcription factor;Transgenic Mice;tumor;tumorigenesis;Up-Regulation

PROJECT_TITLE: Targeting of Krüppel-like Factor 5 (KLF5) in Pancreatic Ductal Adenocarcinoma


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cervical Cancer;Clinical Research;Genetics;Infectious Diseases;Prevention;Primary Health Care;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: FARMINGTON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narrative This project is to develop a simple, rapid, and low-cost paper-based microfluidic device to detect multiple high- risk HPV genotypes for cervical cancer screening at the point of care. The portable diagnostic system can be used in low- and middle-income countries (LMICs) without the need for expensive equipment and well-trained health care personnel.

PI_NAMEs: LIU, CHANGCHUN  (contact)

PROGRAM_OFFICER_NAME: PATRIOTIS, CHRISTOS F

PROJECT_TERMS: Acetic Acids;Address;Air;anti-cancer research;Bioinformatics;Biological Assay;burden of illness;Cancer Etiology;Cellular Phone;Cervical Cancer Screening;Cessation of life;Chemicals;chronic infection;Clinical;clinical application;Clinical Sensitivity;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;cost;COVID-19 detection;Cytology;Data;design;Detection;detection assay;detection method;detection sensitivity;detector;Devices;diagnostic platform;DNA;Electronics;emerging pathogen;Engineering;Equipment;experience;Eye;Feedback;Funding;Genotype;global health;Hand;Health;Health Personnel;health training;high risk;HPV screening;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Image;industry partner;Infectious Diseases Research;innovation;instrument;Interdisciplinary Study;internal control;Laboratories;Lesion;low and middle-income countries;Malignant neoplasm of cervix uteri;Methods;Microfluidic Microchips;Microfluidics;Molecular;multiplex detection;novel;Nucleic Acids;Oncologist;Optics;Paper;Performance;point of care;point-of-care diagnostics;Polymerase Chain Reaction;portability;Printing;Procedures;Process;Published Comment;rapid technique;Reaction;Recommendation;Reporting;Reproducibility;Resource-limited setting;Resources;RNA;Sampling;Sensitivity and Specificity;Services;smartphone application;Specificity;Speed;Swab;System;Technology;technology platform;Temperature;Test Result;Testing;Time;Training;United States Food and Drug Administration;Virus;Visual;Waxes;Women's mortality;World Health Organization;Zambia

PROJECT_TITLE: Low-Cost CRISPR-on-Paper for Cervical Cancer Screening at the Point of Care


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The influenza vaccine needs to be improved since the current vaccine is only 40-60% effective, must be received annually, and provides limited protection against new, potentially pandemic strains of influenza. CD8+ T cells that reside in the lung can protect against current and potentially emerging strains of influenza and could increase the effectiveness of the flu vaccine. This project aims to improve our understanding of the duration and function of lung CD8+ resident memory cells in humans to determine their potential utility in a vaccine strategy for influenza or other respiratory pathogens.

PI_NAMEs: MATTINGLY, CAMERON  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: Alleles;Antibodies;ATAC-seq;Blood;Blood specimen;Bronchoalveolar Lavage;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Survival;Cells;cross immunity;cytokine;Development;Effectiveness;Epigenetic Process;Epitopes;experimental study;Flow Cytometry;flu;Future;Genetic Transcription;Goals;Human;Immune;Immune response;Immune system;Immunity;immunopathology;Immunophenotyping;improved;Individual;Infection;Influenza;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;influenzavirus;insight;Knowledge;Label;Lavage;Lung;Lung Transplantation;Mediating;Membrane Proteins;Memory;Mus;Mutate;Nose;novel;pandemic disease;pandemic influenza;pandemic potential;Parabiosis;Peptides;Persons;Play;Population;Positioning Attribute;pressure;Prevention;Production;pulmonary function;recruit;Research;respiratory pathogen;Respiratory System;respiratory virus;response;Role;Sampling;seasonal influenza;Sentinel;Series;Sorting;Structure of parenchyma of lung;T memory cell;Techniques;Time;tissue resident memory T cell;Tissues;transcriptome sequencing;Transplant Recipients;Transplantation;vaccination strategy;Vaccine Design;vaccine development;vaccine strategy;Vaccines;Viral;Viral Load result;Work

PROJECT_TITLE: Duration and Function of Lung Tissue Resident CD8+ Memory T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-F(20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: OVERALL PROJECT SUMMARY In this Program Project renewal, we bring together investigators with very different expertise and approaches from structural biology, proteomics, immunology, biophysics and computational biology to understand T cell antigen receptor (TCR) signaling. We will study the distinct features of the T cell-expressed tyrosine kinase enzymes that make these most suitable for TCR signaling, how the biochemical features and assembly of particular molecules are used to amplify signals, how distinct signaling pathways coordinate different cellular responses and how signaling circuitry generated enables the T cell to discriminate and respond to signals generated from self-antigens versus pathogen or tumor antigens.

PI_NAMEs: ROOSE, JEROEN  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Address;Agonist;analog;Antigens;Autoantigens;B-Lymphocytes;Biochemical;Biochemistry;Biological;Biophysics;Cell Line;Cell membrane;Cell Physiology;Cells;Characteristics;Collaborations;Computational Biology;Computer Models;Cytoplasm;Development;digital;Discrimination;Distal;Engineering;Ensure;Enzymes;Event;Evolution;Exhibits;experimental study;Family;Family member;Feedback;FRAP1 gene;Gene Expression;Goals;Image;Immunity;Immunology;in vivo;Individual;Kinetics;Knowledge;Lead;Ligands;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;member;Molecular Conformation;mouse model;Nuclear;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Pattern;Peptide/MHC Complex;Phase Transition;Phosphotransferases;Physical condensation;Process;Productivity;programs;Property;Protein Tyrosine Kinase;Proteins;Proteomics;ras Guanine Nucleotide Exchange Factors;Receptor Signaling;reconstitution;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;response;Role;scaffold;Scaffolding Protein;Signal Pathway;Signal Transduction;Signaling Molecule;single molecule;skills;Specificity;structural biology;Structure;synergism;System;T cell regulation;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;TEC Protein Tyrosine Kinase;Tumor Antigens;Tumor Immunity;two-dimensional;Tyrosine Phosphorylation;Work;ZAP-70 Gene

PROJECT_TITLE: Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR


PI_NAMEs: WEISS, ARTHUR  (contact)

PROJECT_TERMS: Budgets;Communication;Complex;Consumption;Funding;Goals;Grant;improved;Institution;Leadership;meetings;Occupational activity of managing finances;Process;programs;Property;Proteomics;Research;Research Personnel;Signal Transduction;Site;Time;United States National Institutes of Health

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Rates of Alzheimer's disease and related dementias (ADRD) among Mexican older adults are projected to grow sharply with the estimated threefold increase of the older adult population by 2030, but the underlying genetic and environmental risk factors for ADRD in this population are not well understood. The proposed study will examine the effects of environmental risk factors, including education, socioeconomic status, literacy, rurality, and migration, on ADRD risk among Mexican older adults, as well as the extent to which these environmental risk factors moderate genetic effects of APOE and a polygenic ADRD risk score recently developed for Mexican ancestral populations. Project findings will identify the role of genetic and environmental influences on ADRD risk among Mexican older adults and facilitate development of targeted intervention strategies that mitigate ADRD risk.

PI_NAMEs: TURESON, KAYLA  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Accounting;Activities of Daily Living;Address;Adult;Affect;African;Age;Aging;aging population;Alleles;Alzheimer's disease related dementia;Alzheimer's disease risk;Amerindian;Apolipoprotein E;Apolipoproteins;cognitive ability;Communities;comorbidity;Data Set;Dementia;dementia risk;Development;Disadvantaged;Disparity;Economic Factors;Economics;Education;Environmental Exposure;Environmental Risk Factor;epidemiologic data;epidemiology study;Ethnic Population;European;European ancestry;Exclusion;Exposure to;Face;gene environment interaction;Genes;Genetic;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Health;healthcare burden;Heritability;Impaired cognition;improved;Incidence;indexing;Individual Differences;individual variation;Inequity;innovation;Intervention;Latinx;Latinx population;Life Cycle Stages;literacy;low socioeconomic status;Measures;Mexican;Mexico;migration;Minority Groups;older adult;Persons;polygenic risk score;Population;population based;Population Heterogeneity;Prevalence;Public Health;racial population;rapid growth;Research;Risk;Risk Factors;risk variant;Role;rural area;rurality;Sampling;social;social factors;socioeconomic disadvantage;Socioeconomic Status;Specific qualifier value;Subgroup;Testing;theories;Training;urban area;Work

PROJECT_TITLE: Environmental Moderation of Genetic Influences on Dementia Risk in Mexican Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetic Testing;Genetics;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Pheochromocytomas and paragangliomas are understudied cancers with no reliable predictors of penetrance for the SDHx hereditary forms and no predictors or curative treatments for metastatic disease. The goals of this proposal are to determine inherited genetic risk loci for sporadic and SDHx-associated tumors in order to identify those at highest risk for screening and surveillance and to identify targets for cancer prevention and therapeutic intervention.

PI_NAMEs: FISHBEIN, LAUREN MICHELLE (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adrenal Glands;Age of Onset;American;Asian;biobank;Biological;Biological Assay;Blood;Cancer Etiology;cancer prevention;Cancer Prevention Intervention;Cancer Prognosis;cancer risk;cancer therapy;Cardiovascular system;Caring;case control;Case/Control Studies;Catecholamines;causal variant;Clinical;clinical care;Clinical Data;Colorado;Complex;curative treatments;design;Detection;Development;Disease;disease prognosis;disease-causing mutation;disorder risk;Division of Cancer Control and Population Sciences;DNA;DNA Repair;early childhood;Emotional;Etiology;Financial Hardship;Fumarates;Gastrointestinal Stromal Tumors;Gene Modified;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genotype;Germ Lines;Germ-Line Mutation;Glioblastoma;Goals;Hereditary Paraganglioma;high risk;Hypoxia;Image;In Vitro;Individual;Inherited;International;Laboratories;Malignant Neoplasms;Metabolic;Metastatic Pheochromocytoma;Methods;Mitochondria;molecular marker;Morbidity - disease rate;Neuroendocrine Tumors;Paraganglioma;Pathogenicity;Pathway interactions;Patient Care;patient subsets;Patients;Penetrance;personalized medicine;personalized screening;Phenotype;Pheochromocytoma;Positioning Attribute;predictive marker;Predisposition;Prevention;Primary Neoplasm;rare variant;Regulatory Element;Renal Cell Carcinoma;Respiratory Chain;response;Risk;risk variant;Role;Sampling;screening;screening guidelines;Secondary to;Stromal Neoplasm;Succinate Dehydrogenase;Succinates;Susceptibility Gene;Syndrome;targeted sequencing;Testing;Therapeutic Intervention;therapeutic target;trait;Translations;tumor;understudied cancer;Variant;working group

PROJECT_TITLE: Inherited genetic variation and penetrance of Hereditary Paraganglioma-Pheochromocytoma Syndrome

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: SALOMON, ARTHUR ROBERT (contact)

PROJECT_TERMS: Affinity Chromatography;Alleles;Amino Acids;analog;Biochemical;Biological Assay;CD8B1 gene;Cell Culture Techniques;Cell Line;Cell Physiology;Cells;Cellular Structures;Collaborations;Collection;computational suite;Computer Analysis;Computer Models;computerized tools;Coupled;Custom;Data;data acquisition;data analysis pipeline;Data Set;design;Detection;Effectiveness;Evaluation;Event;experimental study;Feedback;Funding;Generations;Guanine Nucleotide Exchange Factors;High Pressure Liquid Chromatography;Immunology;improved;Infrastructure;instrument;intermolecular interaction;Knowledge;Label;liquid chromatography mass spectrometry;Maps;mass spectrometer;Mass Spectrum Analysis;Mediating;Methods;Modernization;Molecular;Mus;mutant;Nature;new technology;novel;Paper;Pathologic;Peptides;Peripheral;Phase;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotyrosine;Post-Translational Protein Processing;Process;programs;Property;Protein Analysis;protein profiling;protein protein interaction;protein purification;Proteins;Proteome;Proteomics;PTPRC gene;Publications;Publishing;Receptor Signaling;recruit;Research Personnel;response;Role;Sampling;senior faculty;Signal Pathway;Signal Transduction;Signaling Protein;Site;Source;Speed;src Homology Region 2 Domain;Stable Isotope Labeling;Statistical Data Interpretation;Stimulus;Structure;System;T-Cell Receptor;T-Lymphocyte;Techniques;Therapeutic Intervention;Time;tool;transmission process;Tyrosine;Tyrosine Phosphorylation Site;Universities;ZAP-70 Gene

PROJECT_TITLE: Proteomics Core


PI_NAMEs: KURIYAN, JOHN  (contact)

PROJECT_TERMS: Adaptive Immune System;Adaptor Signaling Protein;Affect;Agonist;Amino Acid Sequence;Antigens;B-Lymphocytes;Behavior;Binding;Biochemical;Biological;Biophysics;CD8B1 gene;Cell Line;Cell Physiology;Cells;Charge;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;design;Diabetes Mellitus;Dimerization;Discrimination;Engineering;Environment;Evolution;Exhibits;exome sequencing;experimental study;Family;Family member;fitness;Future;Genes;Genetic Transcription;Glutamine;Goals;growth factor receptor-bound protein 2;Hematopoietic;Inbred NOD Mice;inhibitor;inorganic phosphate;insight;Insulin-Dependent Diabetes Mellitus;Jurkat Cells;Knock-out;LCP2 gene;Ligands;Lymphocyte-Specific p56LCK Tyrosine Protein Kinase;Malignant Neoplasms;Mediating;member;Membrane;membrane reconstitution;Methods;Molds;Molecular Conformation;Monitor;Mus;Mutagenesis;mutant;Mutation;novel;nuclear factors of activated T-cells;Outcome;pathogen;Peptide/MHC Complex;Pharmaceutical Preparations;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Phylogenetic Analysis;Physiological;pressure;programs;Property;Protein Dephosphorylation;Protein Dynamics;protein purification;Protein Tyrosine Kinase;Proteins;PTPRC gene;receptor;reconstitution;reconstruction;resistance mutation;response;Rest;Role;Scaffolding Protein;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Signaling Molecule;Signaling Protein;single molecule;Site;Sorting;src Homology Region 2 Domain;src-Family Kinases;Stimulus;Structure;Substrate Specificity;Syndrome;T Cell Receptor Signaling Pathway;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Tail;TEC Protein Tyrosine Kinase;Testing;Trees;Up-Regulation;Variant;ZAP-70 Gene

PROJECT_TITLE: Evolution of proximal kinase network in T cells


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Cardiovascular;Neurosciences;Nutrition;Obesity

ORG_CITY: MADISON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The growing incidence of eating disorders and obesity, and their associated health costs have led to intensive research efforts directed at understanding the mechanisms and signaling pathways that control and regulate food intake. This competitive renewal grant application aims at developing innovative mass spectrometry- based technologies and strategies in combination with physiological approaches to characterize neuropeptides and biogenic amines involved in feeding with increased sensitivity, accuracy and throughput. The molecular insights gained from this research promise to increase our knowledge about peptidergic signaling and neuromodulation in the regulation of this essential physiological process, which could ultimately lead to the development of new therapeutic strategies for obesity and eating disorders that have become a big concern of modern societies.

PI_NAMEs: LI, LINGJUN  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Acceleration;Address;Amines;analytical tool;Animals;Applications Grants;Beds;behavior measurement;Behavioral;Biogenic Amines;Biological;Biological Models;Brain region;Cardiac;Cardiac Output;Cardiovascular system;Central Nervous System;Chemicals;Complement;Complex;Coupled;Crustacea;Data;Defect;Development;Disease;Eating;Eating Disorders;Elements;energy balance;Exclusion;Family;feeding;Feeding behaviors;Food Energy;Food Intake Regulation;Health Care Costs;Heart;Homeostasis;Hormones;imaging study;Imaging Techniques;improved;In Situ;in vivo;Incidence;Individual;information processing;Infusion procedures;innovation;innovative technologies;insight;Knowledge;Liquid substance;Maps;Mass Spectrum Analysis;Measurement;Measures;Methodology;Methods;Microdialysis;Modeling;Modernization;Modification;Molecular;nanosecond;Nervous System;neural circuit;neurochemistry;Neurons;Neuropeptides;neuroregulation;Neurosecretory Systems;Neurotransmitters;novel;novel therapeutic intervention;novel therapeutics;Obesity;Organ;Outcome;Pathway interactions;Pattern;peptide hormone;Peptide Signal Sequences;Peptides;Physiological;Physiological Processes;Physiology;Play;Preparation;Process;Protein Isoforms;Rattus;Reaction;Regulation;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;Societies;Source;Specificity;spectrograph;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Surface;System;Techniques;Technology;technology development;technology validation;Testing;Time;tool;Translating;Work

PROJECT_TITLE: Mass Spectrometric Studies of Neuropeptides in Feeding

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


PI_NAMEs: CHAKRABORTY, ARUP K. (contact)

PROJECT_TERMS: adaptive immune response;Agonist;Alleles;Binding;Biochemistry;cancer cell;CD3 Antigens;Cells;Complex;Computer Models;computer studies;Data;Dependence;Discrimination;Disease;Distal;Event;experimental study;Feedback;Genetic;Genetic Transcription;Half-Life;immunopathology;in vivo;Individual;inhibitor;Kinetics;Lead;Ligands;Malignant Neoplasms;Mediating;Membrane;Modeling;Molecular;mouse model;mutant;Noise;pathogen;Pathway interactions;Patients;Peptide/MHC Complex;Peptides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physical condensation;Physics;Play;Probability;programs;Property;Protein Tyrosine Kinase;Proteins;Reagent;receptor;Receptor Signaling;reconstitution;recruit;Regulation;response;Rest;Role;Series;Signal Pathway;Signal Transduction;single molecule;Source;Specificity;Study models;System;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;Time;Titrations;tool;Tyrosine Phosphorylation;Work;ZAP-70 Gene

PROJECT_TITLE: The role of positive and negative regulation on ligand discrimination by the TCR signaling pathway


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE The Center for Dental, Oral, & Craniofacial Tissue & Organ Regeneration (C-DOCTOR) a public-private consortium focused on accelerating promising tissue engineering/regenerative medicine therapies for dental, oral, and craniofacial tissue and organ regeneration to human clinical trials. Our overall vision for C-DOCTOR is to be a comprehensive national resource center for the clinical translation of innovative regenerative technologies to replace DOC tissues or organs lost to congenital disorders, traumatic injuries, diseases, and medical procedures. In Stage 3, we will continue to provide interdisciplinary translational project teams with fully customized support from expert scientists, clinicians, commercialization strategists and regulatory advisors as the teams refine their products, complete their IND/IDE-enabling studies, transition to current good laboratory/manufacturing practices methods for scale-up, form strategic partnerships, and interact with the FDA ahead of Phase I clinical trials.

PI_NAMEs: CHAI, YANG  (contact);LOTZ, JEFFREY C.

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Acceleration;Adoption;Advocate;Biocompatible Materials;Biomedical Research;Brain;Businesses;California;Center for Translational Science Activities;Clinical;clinical center;Clinical Research;clinical translation;Clinical Trials;Collaborations;commercialization;Communities;Congenital Disorders;craniofacial;Craniofacial Abnormalities;craniofacial tissue;cranium;Dental;Dentists;Development;Disease;Ecosystem;education resources;Ensure;experience;Face;Goals;Health;Human;improved;Incentives;Industry;Infrastructure;innovation;Institution;knowledge base;knowledge hub;knowledgebase;Laboratories;Life Experience;Los Angeles;manufacture;Marketing;Medical;Methodology;Methods;Mission;National Institute of Dental and Craniofacial Research;Oral;oral tissue;Organ;organ regeneration;Outcome;Patient Care;Patients;Phase I Clinical Trials;pre-clinical;preclinical study;Preclinical Testing;Privatization;Probability;Procedures;Process;programs;Protocols documentation;recruit;regenerative;Regenerative Medicine;regenerative therapy;Regulation;Reproducibility;Research Personnel;Research Project Grants;Resources;San Francisco;scale up;scientific hub;Scientist;Sense Organs;Series;Shapes;success;Surgeon;Technology;Tissue Engineering;tissue regeneration;Trauma;Traumatic injury;Universities;Vision

PROJECT_TITLE: Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: GROVES, JAY T. (contact)

PROJECT_TERMS: Address;Agonist;Antigens;Autoantigens;Binding;Biology;Cell membrane;Cells;cellular imaging;Chemicals;Complex;Data;Dimensions;dimer;Discrimination;Elements;engineered T cells;Engineering;Event;Exhibits;experimental study;Feedback;Foundations;Gene Expression;Image;Imaging Techniques;Immune system;Individual;insight;Investigation;Kinetics;MAP Kinase Gene;Measurement;Modification;Molecular;mutant;Mutation;Noise;novel;Nuclear;Output;Pathway interactions;Peptide/MHC Complex;Phase Transition;Phosphorylation;Physical condensation;Process;Property;Proteins;Reaction;receptor binding;Receptor Signaling;reconstitution;Resolution;response;Role;scaffold;Scaffolding Protein;Series;Signal Transduction;Signaling Molecule;single molecule;Structure;System;T Cell Receptor Signaling Pathway;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutic development;two-dimensional;Variant;Work

PROJECT_TITLE: The role of LAT protein condensation phase transitions in T cell signaling


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Higher order organization of membrane proteins and lipids is pivotal to various cellular signaling pathways. Combining lipid vesicle technology with native mass spectrometry, the project aims to develop a novel experimental platform that can provide a quantitative molecular view of organization of membrane proteins and lipids in the bilayer. With membrane proteins being targets of more than 60% marketed drugs, the transformative potential of this approach lies in its broad impact in understanding various membrane associated pathological states.

PI_NAMEs: GUPTA, KALLOL  (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Ablation;Accounting;Address;Benchmarking;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biological Models;Biological Process;biophysical properties;cell growth;cell growth regulation;Cell membrane;Cell Physiology;Cells;Cellular Membrane;cellular targeting;Chemicals;Collaborations;Complex;complex biological systems;Crowding;Data;Detection;detection platform;Detergents;Disease;drug market;Endoplasmic Reticulum;Environment;experimental study;Goals;Human;Impairment;In Vitro;insight;Lateral;Link;Lipid Bilayers;Lipid Binding;Lipids;Liquid substance;Malignant Neoplasms;Mass Spectrum Analysis;Membrane;membrane assembly;Membrane Lipids;Membrane Proteins;membrane reconstitution;Methodology;Methods;Mitochondria;Molecular;Molecular Analysis;Mutation;Nerve Degeneration;Nervous System Disorder;Neurobiology;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;new technology;next generation;novel;Pathologic;Physiological;Play;pressure;Property;protein complex;Proteins;Proteome;Protocols documentation;reconstitution;Role;Signal Pathway;Signal Transduction;SNAP receptor;Speed;Stimulus;stoichiometry;Synapses;Synaptic Vesicles;Synaptophysin;System;technological innovation;Technology;tool;Vesicle;vesicular release

PROJECT_TITLE: Understanding organization of membrane proteins and lipids through lipid vesicle native mass spectrometry


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Dietary Supplements;Microbiome;Nutrition;Pediatric;Prevention

ORG_CITY: HADLEY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative This proposed study seeks to promote health by two primary means. First, it investigates a beneficial host- microbial interaction potentially mediated by human milk with implications to infant nutrition and metabolism. Second, it may provide molecular targets for diagnostics and interventions to tune nitrogen metabolism efficiency in infants and potentially adults.

PI_NAMEs: SELA, DAVID A. (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Adult;Amino Acids;Ammonia;Basal metabolic rate;Bifidobacterium;Binding;Biochemical Pathway;Birth;Colon;Communities;Development;Diagnostic;Diet;dietary;Dietary Intervention;Goals;gut colonization;gut microbiome;Health Promotion;Homeostasis;host-microbe interactions;Human Milk;Immune system;In Vitro;in vitro Model;Infant;infant gut microbiome;Infant Health;infant nutrition;innovation;Intervention;Investigation;Knowledge;Life;Link;Mediating;Metabolic;Metabolism;microbial;microbial community;microbial host;microbiome;microbiome composition;microbiota;Milk;Modeling;Molecular;Molecular Target;Mothers;Neonatal;Nitrogen;nitrogen metabolism;Nursing infant;Nutrient;nutrition;Nutritional;Nutritional status;Oligosaccharides;pathogen;Pathway interactions;Phenotype;Physiological;Physiology;Population;pre-clinical;Recycling;Research;Role;Source;Structure;Systems Development;targeted treatment;Testing;tool;Urea;Urea Nitrogen;Urease;usability;Vitamins

PROJECT_TITLE: Human milk urea nitrogen is recycled by Bifidobacterium infantis to impact the emergent physiology of the infant gut microbiome

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


PROJECT_TERMS: Address;Agonist;analog;Autoimmune Diseases;Biological Assay;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular biology;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communication;Data;Development;digital;Discipline;Discrimination;effector T cell;Event;Feedback;Foundations;FRAP1 gene;Homeostasis;Human;Immune;immune function;Immunity;In Vitro;in vivo;Individual;innovation;innovative technologies;insight;Kinetics;Lipid Bilayers;LoxP-flanked allele;MAP Kinase Gene;Molecular;mouse model;Mus;novel;Output;p38 Mitogen Activated Protein Kinase;pathogen;Pathway interactions;Pattern;Peptide/MHC Complex;Phase Transition;Phosphotransferases;Physical condensation;Process;Progress Reports;Proliferating;Property;ras Guanine Nucleotide Exchange Factors;Regulatory T-Lymphocyte;Research;Seminal;Signal Transduction;Signaling Protein;Structure;T cell regulation;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;tumor;Tumor Immunity;tumor immunology;Visualization

PROJECT_TITLE: Canonical and non-canonical RasGEF pathways in T cells


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project narrative Scientific fields such as astronomy and particle physics have had tremendous success using an “observatory” based approach to data collection, in which researchers propose experiments to be carried out in centralized facilities too complex and expensive to be operated by individual laboratories. We will apply this model to neuroscience by opening the Allen Institute Brain Observatory’s state-of-the-art optical and electrophysiological data collection pipelines to the entire neuroscience community. This will lower barriers to testing new hypotheses about brain function, bring in new computational and theoretical talents into the field, and enhance the reproducibility of results in brain research, thereby accelerating progress toward an integrated understanding of neural activity in health and disease.

PI_NAMEs: KOCH, CHRISTOF ;LECOQ, JEROME ANTHONY-JEAN (contact)

PROGRAM_OFFICER_NAME: TRZCINSKI, NATALIE KATHERINE

PROJECT_TERMS: Acceleration;Address;Anatomy;Animals;Area;Astronomy;Back;barrier to testing;Behavioral;Biomedical Research;Blinded;Brain;BRAIN initiative;brain research;Calcium;cell type;Cells;cloud based;Code;Communities;Complex;Core Facility;Data;data acquisition;Data Analyses;Data Collection;data format;Data Set;data standards;design;Detection;Disease;Educational workshop;Electrophysiology (science);Engineering;Environment;experimental study;falls;Fostering;Funding;Future;Glass;Hawaii;Health;Image;imaging platform;implantation;in vivo;Incentives;Individual;innovation;Institution;instrument;Knowledge;Laboratories;Learning;Location;Machine Learning;Modeling;Modernization;Mus;neural;neural circuit;Neurons;neurophysiology;Neurosciences;novel;Operative Surgical Procedures;Optics;particle physics;Physiology;Procedures;Process;programs;Protocols documentation;Publications;Quality Control;Reproducibility;Reproducibility of Results;Research;Research Personnel;Resources;Running;Scientist;Silicon;Site;software development;Standardization;statistics;Structure;success;Surveys;System;Talents;Technical Expertise;Techniques;Technology;Testing;theories;tool;Training;two-photon;Variant;Visual;visual stimulus;web portal

PROJECT_TITLE: OpenScope: A Platform for High-Throughput and Reproducible Neurophysiology Open to External Scientists to Test Impactful Theories of Brain Function


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: Narrative The enormous complexity of brain interactions makes understanding brain diseases such as stroke, autism, and Alzheimer disease extremely difficult. Part of this complexity lies in the need to understand how the chemicals that underlie learning and memory, and brain energy, interact with the electrical signals that travel along nerve fibers. We are extending NEURON, one of the most widely used nerve and brain computer simulators, to simulate chemical reactions both inside and outside of cells. This will allow us to better understand the roles of oxygen, toxins and drugs in brain dysfunctions of neurological and psychiatric disease.

PI_NAMEs: LYTTON, WILLIAM W (contact);MCDOUGAL, ROBERT A.

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Adoption;Alzheimer's Disease;Amyloid;application programming interface;artificial neural network;autism spectrum disorder;Bayesian Analysis;Biological;Biology;Biomedical Engineering;Blood;Body System;Brain;Brain Chemistry;Brain Diseases;brain dysfunction;brain research;Cells;chemical addition;Chemical Agents;chemical reaction;Chemicals;Clinical;Communities;Complement;Complex;Computational Biology;computational neuroscience;computer science;Computers;Dendrites;Development;Differential Equation;Diffusion;Disease;Documentation;Edema;Education;Educational process of instructing;Educational workshop;Electrophysiology (science);Epilepsy;Equation;experimental study;extracellular;Failure;Functional disorder;Funding;Future;Gap Junctions;Gatekeeping;Genome;Heart;High Performance Computing;Homeostasis;Hormones;Human;improved;in vivo;Information Theory;interoperability;Intracellular Space;Ischemia;Kinetics;Learning;Link;Manuals;Medical;meetings;Memory;Mental disorders;Modality;Modeling;multi-scale modeling;Myocardial Infarction;neglect;neocortical;Nerve;Nerve Degeneration;Nerve Fibers;Nervous System;Nervous System Disorder;neural;Neurologic;Neurons;Neurosciences;neurotechnology;Neurotransmitters;novel;online course;online tutorial;Organ;Oxygen;Pathology;Pattern Recognition;Performance;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Play;postsynaptic;pressure;presynaptic;Process;Proteome;Pythons;Reaction;Reading;reconstruction;Recovery;Research;Research Personnel;Rest;reuptake;Role;Running;Second Messenger Systems;Signal Transduction;simulation;Speed;Stroke;Structure;Synapses;Synaptic Transmission;syntax;synuclein;Systems Biology;tau Proteins;Techniques;Thinking;Time;Tissues;tool;Toxin;transcriptome;Travel;Trees;Work

PROJECT_TITLE: Extension of NEURON simulator for simulation of reaction-diffusion in neurons


NIH_SPENDING_CATS: Microbiome

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative We use a natural host colonization model system to study how competitive interactions between bacterial populations impact which populations can infect and persist inside a host. We found that bacterial colonizers use a type VI secretion system (T6SS) to kill competing strains for access to host colonization sites. We will determine how these bacteria target other cells for killing, as well as the extent to which competition influences the spatial arrangements of members comprising a natural host-associated microbiome.

PI_NAMEs: SEPTER, ALECIA  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Bacteria;Biological Models;Biological Process;cell killing;Cells;Cessation of life;Communicable Diseases;Communities;Development;disorder risk;dysbiosis;Genetic Determinism;Goals;Health;host colonization;Human;improved;Light;Mediating;member;microbial;microbiome;microbiome alteration;microbiome composition;Molecular;Organ;Pathogenicity;Population;Predisposition;Protein Export Pathway;Proteins;Role;Shapes;Site;Squid;Structure;Syringes;System;Work

PROJECT_TITLE: Genetic determinants of interbacterial competition during host colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dissemination and Implementation Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative Elevated mental health problems have been documented in children of divorced families – over 8.1 million in the US – and in their parents. While behavioral parent training interventions, including digital interventions, have demonstrated success to reduce children’s mental health problems, they have shown weaker effects in divorced parents with elevated psychological distress, and digital fully self-administered interventions have shown no effects to reduce the distress of divorced parents. By developing digital mindfulness training components and adding them to an existing evidence-based parenting intervention, as a combined, web- based, self-administered intervention, this project has great potential to maximize its reach and impact, reducing mental health problems in high-risk divorced families.

PI_NAMEs: ZHANG, NA  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: acceptability and feasibility;Address;Anxiety;Applied Research;Arizona;Attention;Award;Behavioral;career;Child;Child Mental Health;Child Rearing;Clinical;clinical training;cognitive control;Collaborations;Connecticut;court;Data;design;digital;digital intervention;Distress;Divorce;Dose;Educational Intervention;Educational workshop;Effectiveness;Electronics;Emotions;evidence base;Evidence based practice;executive function;experience;Family;Feedback;Focus Groups;Goals;group intervention;Health;high risk;high risk parents;Human Development;implementation measures;improved;Individual;Informal Social Control;innovation;Intervention;Interview;Learning Skill;Literature;Massachusetts;Measures;Meditation;Mental Depression;Mental Health;Mental Health Services;Mentorship;Methods;Military Personnel;mindfulness;mindfulness intervention;Mindfulness Training;Modeling;Mothers;National Institute of Mental Health;novel;online resource;Online Systems;Outcome;Paper;parenting intervention;Parents;Philosophy;Policies;prevent;primary outcome;Principal Investigator;programs;prototype;psychological distress;Psychologist;Public Health;Randomized;Reporting;Research;Research Activity;Research Personnel;Research Support;Risk;Science;Self Administration;service providers;skills;Socialization;Stress;success;symposium;Techniques;Testing;theories;therapy development;Training;Training Activity;Training Programs;Universities;uptake;usability;user centered design;Washington;webinar;Wisconsin;X Inactivation

PROJECT_TITLE: A digital mindfulness-informed parenting intervention for high-risk divorced families


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE Several psychiatric disorders including post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are characterized by excessive and persistent emotional responses to conditioned cues. Exposure therapy, where these cues are repeatedly presented without the expected threatening or rewarding outcome, helps diminish the conditioned response to these cues, but they often return in a subset of patients. This research could open the possibility for the use of CO2 reactivity as a transdiagnostic screening tool to determine whether an individual with addiction or a trauma/anxiety disorder would maintain their response to exposure therapy and thus be a good candidate for treatment.

PI_NAMEs: RASKIN, MARISSA RENEE (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;alcohol cue;alcohol exposure;alcohol memory;alcohol use disorder;Alcohols;Amygdaloid structure;antagonist;Anxiety Disorders;Association Learning;Attenuated;Basic Science;Behavior;Behavior Therapy;Behavioral;Brain;brain tissue;Carbon Dioxide;career;Cells;Clinic;conditioned fear;Conditioned Reflex;conditioning;Cues;Data;diagnostic screening;Disease;Emotional;Exposure to;Extinction;fear memory;Flushing;Food;FOS gene;Fright;Goals;Hippocampus;Human;hypocretin;Hypothalamic structure;Immunohistochemistry;improved;Individual;Individual Differences;Knowledge;Label;Laboratories;large datasets;Lateral;Lead;Learning;learning extinction;long term memory;Medial;Memory;Mental disorders;neural circuit;Neurons;Outcome;patient subsets;Patients;Phase;Phenotype;Post-Traumatic Stress Disorders;predicting response;Prefrontal Cortex;prevent;Rattus;receptor;Recording of previous events;reduce symptoms;reinforcer;Research;response;Rewards;Rodent;Sampling;Screening procedure;Statistical Models;statistics;Stimulus;Stress;System;Testing;Time;Training;Translating;Trauma;traumatic event;treatment strategy;Work

PROJECT_TITLE: CO2 reactivity and orexin activation as predictors of extinction phenotype to fear and reward cues


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Social Determinants of Health;Substance Misuse

ORG_DEPT: MISCELLANEOUS

PHR: PROJECT NARRATIVE The HIV epidemic in many global settings is highly concentrated among people who inject drugs (PWID), and efforts to scale up HIV treatment have largely failed to reach this population. The proposed research utilizes a mixed methods, implementation science-focused approach to explore the understudied relationship between clinic characteristics (which can act as significant barriers or facilitators to intervention implementation) and the scale-up, adaptation, and sustainment of an evidence-based systems navigation and psychosocial counseling intervention for PWID with HIV in Vietnam. Findings can inform governments globally on how to distribute limited resources, based on clinic characteristics, to scale up and sustain effective HIV interventions for PWID, ultimately reducing mortality and improving wellbeing for PWID with HIV across low and middle-income countries.

PI_NAMEs: BARTELS, SOPHIA M (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Affect;antiretroviral therapy;arm;barrier to care;career;Caring;Characteristics;Climate;Clinic;cost;Counseling;Data;Death Rate;design;Epidemic;evidence base;Evidence based intervention;Excision;experience;Fellowship;follow-up;Foundations;Funding;Future;Goals;Government;Health;HIV;Human immunodeficiency virus test;implementation barriers;implementation facilitators;implementation intervention;implementation science;implementation strategy;implementation study;implementation trial;improved;Incidence;indexing;Individual;Injecting drug user;Intervention;Interview;Knowledge;Leadership;Linear Models;low and middle-income countries;Maps;Measurement;medication-assisted treatment;Mentorship;Methods;Modification;mortality;National Institute of Drug Abuse;novel;organizational readiness;Outcome;Parents;Participant;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;Process;Provider;Province;psychosocial;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;research to practice;Resources;Sample Size;scale up;Scientist;Site;skills;Statistical Data Interpretation;Statistical Models;success;Surveys;System;Testing;theories;Time;Vietnam;Vietnamese;Viral;Work

PROJECT_TITLE: A Mixed Methods Assessment of Clinic Characteristics Associated with Successful Scale-up & Sustainment of Systems Navigation & Psychosocial Counseling for People Who Inject Drugs with HIV in Vietnam


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Complementary and Integrative Health;Data Science;Dietary Supplements;Genetics;Machine Learning and Artificial Intelligence;Natural Products;Networking and Information Technology R&D (NITRD);Nutrition;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE: With increased market demand for medicinal plant products comes a greater risk for adulteration of botanicals, posing a large health risk to consumers. The innate complexity of herbal products makes authentication and identification of bioactive compounds challenging. Thus, this proposal aims to combine advanced metabolomic (UPLC-HRMS), DNA barcoding, and bioactivity data with multivariate statistical models and machine learning algorithms for improved authentication schemes and bioactive compound discovery, using Ocimum (basil) as a model species, to develop novel approaches with application to a range of botanical products.

PI_NAMEs: ABRAHAM, EVELYN  (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Anti-Bacterial Agents;antimicrobial;Antioxidants;Attention;Bar Codes;Biological Assay;Biological Models;biomarker discovery;Botanical dietary supplements;Botanicals;cell growth;Chemicals;Chemistry;Classification;Creativeness;cytotoxic;cytotoxicity;Data;Data Collection;data modeling;Data Set;Detection;Development;DNA;drug development;Dryness;Ensure;Flavonoids;Future;Genetic;Genetic Fingerprintings;genomic locus;Goals;Health;Health Benefit;Health Promotion;Herbal Medicine;Herbal supplement;improved;in vivo;Industry;Investigation;Least-Squares Analysis;Machine Learning;machine learning algorithm;machine learning model;Marketing;Medicinal Plants;Medicine;metabolomics;methicillin resistant Staphylococcus aureus;Methods;Mission;model building;model organism;Modeling;Modernization;Molecular Conformation;molecular marker;Multiomic Data;National Center for Complementary and Integrative Health;Natural Products;neoplastic cell;novel;novel strategies;Ocimum;Ocimum basilicum;Output;Phytochemical;Plants;Property;Protocols documentation;Quality Control;random forest;Recommendation;Research Personnel;Resolution;Risk;Safety;Sampling;Scheme;small molecule;Statistical Models;statistics;System;Testing;Therapeutic;tool;Toxicology;Training;trustworthiness;Validation;Variant;Visualization;Voting

PROJECT_TITLE: Multivariate Statistics and Machine Learning for Quality Control of Dried Ocimum Products


ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Difficulty initiating or executing appropriate movement is characteristic of neurological disorders including Parkinson’s disease and ataxias, while abnormally repetitive movements are characteristic of neurological disorders such as Tourette Syndrome and neuropsychiatric disorders such as OCD and ASD. This research is aimed at understanding the neuronal mechanisms by which C. elegans nematodes initiate, execute and stabilize appropriate motor actions, in order to make predictions about how dysregulation of motor action patterns arise.

PI_NAMEs: BUCK, FRIEDERIKE  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Ablation;Address;Affect;Ataxia;autism spectrum disorder;Behavior;Behavioral;Behavioral Mechanisms;Brain;Caenorhabditis elegans;Characteristics;Chemotaxis;combinatorial;Complex;connectome;Disease;Environment;experimental study;flexibility;Food;Future;Gene Library;Generations;Genetic;Genetic study;Gilles de la Tourette syndrome;Health;Individual;Interneurons;Laboratories;Learning;Locomotion;Mental disorders;Modeling;Motor;motor control;Motor output;Movement;Nematoda;Nervous System Disorder;neural;neural circuit;Neurons;neuropsychiatric disorder;novel;optogenetics;Output;Parkinson Disease;Pathologic;Patients;Pattern;Phenotype;Physicians;Physiological;Probability;Production;Research;response;Role;Scientist;screening;Signal Transduction;System;Testing;Time;tool;Training

PROJECT_TITLE: Neuronal Control of Motor State Transitions


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Radiation Oncology;Skin Cancer

ORG_CITY: DAVIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Dogs are outbred companion animals that develop spontaneous cancers in the setting of an intact immune system, allowing for the study of complex immune interactions during cancer therapies while also addressing endpoints of efficacy and toxicity. This proposal seeks to capitalize on the dog model to speed the translation of novel immunotherapy approaches with the goal of enhancing and building on readily available and commonly utilized immunotherapies in human cancer patients while at the same time helping to train the next generation of translational comparative oncologists.

PI_NAMEs: RAZMARA, ARYANA  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Adoptive Transfer;Adverse event;Allogenic;anti-PD-L1 antibodies;Antigen-Antibody Complex;Autologous;Biological Assay;Biopsy;Blood;cancer immunotherapy;Cancer Model;Cancer Patient;cancer therapy;canine model;Canis familiaris;career;CD8-Positive T-Lymphocytes;Cells;Cellular immunotherapy;checkpoint inhibition;chimeric antigen receptor T cells;Clinic;Clinical;clinical effect;Clinical Trials;clinically relevant;Combination immunotherapy;Combined Modality Therapy;companion animal;comparative;Correlative Study;cytokine;cytotoxic;cytotoxicity;Data;Development;dimensional analysis;Disease;Dose;Effector Cell;Evaluation;exhaustion;experience;first-in-human;Flow Cytometry;Functional disorder;Future;Gene Expression Profile;Genetic;genetic signature;Genomics;Goals;Granzyme;Homing;Human;Immune;immune checkpoint blockade;Immune system;Immunologics;Immunooncology;immunoregulation;Immunosuppression;Immunotherapy;improved;innovation;insight;Knowledge;Ligands;lymph nodes;Lymphocyte;Lymphoma;Malignant Neoplasms;Mediating;Melanoma;Methods;Modeling;Modification;mouse model;Mus;Natural Killer Cell Immunotherapy;Natural Killer Cell toxicity;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;next generation;NK Cell Activation;NK cell therapy;novel;novel therapeutics;Oncologist;Oncology Group;Organ;Osteosarcoma;palliative;Pathway interactions;Patients;PD-1/PD-L1;PD-L1 blockade;PDL1 inhibitors;Phase II Clinical Trials;phase II trial;Phenotype;pilot trial;Population;Pre-Clinical Model;predicting response;primary endpoint;Prognosis;programmed cell death ligand 1;Progression-Free Survivals;Radiation;Radiation therapy;Recording of previous events;regional difference;Research;Residencies;response;Safety;safety assessment;Sampling;Scientist;single cell sequencing;skills;Solid Neoplasm;species difference;Speed;standard of care;success;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Tissues;tool;Toxic effect;trafficking;Training;transcriptome;transcriptome sequencing;Translating;translational study;Translations;treatment response;tumor;tumor immunology;tumor microenvironment;Unresectable;Up-Regulation;Variant

PROJECT_TITLE: Combining Radiation, Allogeneic Natural Killer Immunotherapy, and PD-L1 blockade in Dogs with Naturally-Occurring Melanoma


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE V(D)J recombination stand at the basis of our immune system, and its dysfunction causes severe human immunodeficiency syndromes, genomic instability and cancer. The goal of this study is to define the molecular events that govern this intricate process under normal and aberrant conditions using innovative technology. Furthering our understanding of the mechanisms of V(D)J recombination and related disease would bring us closer to mechanism-based therapeutics.

PI_NAMEs: ROTHENBERG, ELI  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immunity;Address;Affect;Antigen Receptors;B-Lymphocytes;Binding;Biochemical;Biological;Biological Assay;Cell Line;Cell Nucleus;Cells;Chromatin;Chromosomal translocation;Chromosome Deletion;Complex;Defect;Disease;DNA;DNA Damage;DNA Double Strand Break;DNA Ligation;DNA Repair;Double Strand Break Repair;Ephrin-A5;Event;experimental study;Functional disorder;Genetic Recombination;Genomic Instability;Goals;Heart;HMGB1 gene;Human;IgK;Immune system;immunodeficiency;Immunologic Deficiency Syndromes;In Vitro;in vivo;Individual;innovation;innovative technologies;insight;Ionizing radiation;Kinetics;Knowledge;Malignant Neoplasms;Mammalian Cell;Mediating;Methods;Molecular;Monitor;mutant;Mutation;nanoscale;Nonhomologous DNA End Joining;Nuclear;Nucleic Acid Regulatory Sequences;Pathway interactions;Peptide Signal Sequences;Phase;Process;Proteins;Radiation Tolerance;Reaction;reconstitution;recruit;Regulation;repaired;Research;Resolution;response;Series;Severe Combined Immunodeficiency;single molecule;Site;spatiotemporal;superresolution imaging;System;Techniques;Therapeutic;Time;V(D)J Recombination;virtual;Visualization

PROJECT_TITLE: Mechanism and Fidelity of RAG mediated DNA recombination

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: Insomnia is a serious health problem in Veterans suffering from chronic Traumatic Brain Injury (TBI) and often associated with extensive prescription of sleeping medications. Although safer, even the latest “sleeping pills” can lead to daytime impairment and risk of abuse. Thus non-pharmacological treatments for insomnia have been pursued as alternatives to medications. Cognitive Behavior Therapy for Insomnia (CBT-I) is the term widely used to describe therapies that combine behavioral and cognitive therapies for insomnia. The combined CBT-I approach has well-documented efficacy. Between 2012 and 2014 over 650 VA mental health clinicians have received extensive training in CBT-I. Although CBT-I has been suggested to be a good treatment alternative to pharmacological approaches its efficacy has not yet been sufficiently demonstrated in TBI associated insomnia. We propose to address this gap in our knowledge with a carefully designed clinical trial comparing the benefits of CBT-I with an active control/placebo condition in Veterans with TBI.

PI_NAMEs: FURST, ANSGAR J. (contact)

PROJECT_TERMS: active control;Address;affective disturbance;Aftercare;alternative treatment;Arousal;Beds;Behavior Therapy;Characteristics;Chronic;Chronic Insomnia;clinical center;Clinical Trials Design;Cognitive;cognitive benefits;Cognitive deficits;Cognitive Therapy;Collaborations;Combined Modality Therapy;comorbidity;Data;design;Education;efficacy evaluation;evidence base;Fatigue;follow-up;Future;Health;Health Surveys;Healthcare Systems;Hospitals;Impairment;improved;improved outcome;indexing;Individual;Injury;Inpatients;insight;Intervention;Joints;Knowledge;Manuals;Measures;Mediator;Mental disorders;Mental Health;Meta-Analysis;mild traumatic brain injury;Modeling;Multiple Trauma;Nonpharmacologic Therapy;Outcome;Outcome Measure;outcome prediction;Pain;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Placebos;Post-Traumatic Stress Disorders;primary outcome;Quality of life;Randomized;Randomized Controlled Clinical Trials;randomized, clinical trials;Randomized, Controlled Trials;Recording of previous events;Rehabilitation therapy;Research;Research Design;Research Project Grants;response;Risk;screening;secondary outcome;Severities;SF-36;side effect;Site;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleeping pill;Sleeplessness;TBI Patients;TBI treatment;Testing;Time;Training;Traumatic Brain Injury;Treatment outcome;trial comparing;Veterans;War

PROJECT_TITLE: Cognitive behavioral therapy for insomnia in chronic traumatic brain injury

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Primary Health Care;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PUBLIC HEALTH RELEVANCE  Alcohol Use Disorders (AUDs) are a significant public health problem which contribute to high levels of mortality, morbidity and healthcare costs, and while safe and effective medications are available for treating AUDs, there is reluctance to prescribe and they are underused, particularly in primary care. There is little research on interventions to improve primary care-based AUD medication delivery and addiction treatment initiation; to address this gap, this pragmatic, cluster-randomized trial in adult primary care clinics in a healthcare system with a diverse membership will examine the effectiveness of an innovative, multi-faceted intervention, the Addiction Telemedicine Consultant (ATC) service. The ATC will provide a centralized, flexible, expert addiction medicine consultation to primary care physicians (PCPs) and their patients with AUDs, via video, telephone or email consultation, and findings from this study could spur wider adoption of ATC in health systems as a standard practice in primary care settings, and profoundly affect how we treat and investigate the full spectrum of unhealthy alcohol use.

PI_NAMEs: STERLING, STACY ANN (contact)

PROGRAM_OFFICER_NAME: KWAKO, LAURA ELIZABETH

PROJECT_TERMS: acamprosate;Accident and Emergency department;addiction;addiction treatment referral;Address;Adoption;Adult;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol screening and brief intervention;alcohol use disorder;arm;care systems;Caring;Characteristics;clinical care;Clinical Pharmacists;Clinical Services;Cluster randomized trial;Consult;Consultations;continuing medical education;cost;Data;design;Disulfiram;drinking;Drug Prescriptions;effectiveness evaluation;Electronic Health Record;Electronic Mail;Elements;ethnic disparity;Ethnic Origin;evidence base;Feasibility Studies;Feedback;flexibility;follow-up;Formulation;Frequencies;gender disparity;Health Care Costs;Health Personnel;health service use;Health system;Healthcare Systems;Heavy Drinking;implementation outcomes;improved;Injectable;innovation;inpatient service;insight;Intervention;Interview;Literature;Logistics;Medical;medical complication;medical specialties;Medicine;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;multi-component intervention;Naltrexone;Oral;patient population;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Pilot Projects;Primary Care;primary care clinic;Primary Care Physician;primary care provider;primary care setting;primary care visit;programs;Provider;Public Health;public health relevance;racial disparity;Research;Route;routine care;screening, brief intervention, referral, and treatment;service utilization;Services;socioeconomics;Structure;Techniques;Telemedicine;Telephone;Time;tool;Training;Training and Education;treatment arm;treatment as usual;urgent care;usual care arm;Visit

PROJECT_TITLE: Addiction Telemedicine Consultation in Primary Care: Increasing Access to Pharmacotherapy and Specialty Treatment for Alcohol Problems

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA(03)-3]


ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative Cytochromes c play an essential role in bioenergetics, functioning in diverse electron transport chains for aerobic/anaerobic respiration, photosynthesis and detoxification, which are critical for bacterial survival. The proposed studies strive to elucidate the molecular mechanisms of cytochrome c biogenesis, specifically heme delivery, trafficking and attachment. Investigation of these pathways will provide insights into two fundamental, yet poorly understood, biological processes, cytochrome c biogenesis and heme trafficking, laying the foundation for future studies on other heme transporters.

PI_NAMEs: SUTHERLAND, MOLLY CUDDY (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Address;Aerobic;antimicrobial;Bioenergetics;Biogenesis;Biological;Biological Models;Biological Process;Catalysis;Cell Physiology;cofactor;cytochrome c;Cytoplasm;cytotoxicity;Drug Metabolic Detoxication;Electron Transport;Environment;Escherichia coli;Eukaryota;Foundations;Future;Heme;heme receptor;Hemeproteins;Individual;insight;Integral Membrane Protein;Investigation;Knowledge;Learning;Ligase;Membrane;Membrane Proteins;Molecular;Molecular Chaperones;Nature;novel;Organism;pathogen;Pathway interactions;periplasm;Photosynthesis;Play;Positioning Attribute;Prokaryotic Cells;protein function;protein purification;Reaction;Recombinants;Regulation;Respiration;Role;Signal Transduction;System;trafficking;Work

PROJECT_TITLE: Heme trafficking in prokaryotic cytochrome c biogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE  The subfamily of the tandem Coronins forms a structurally unique class among the extensive family of the Coronins, however to date their actin- regulatory functions remain completely unknown. Using a combination of single molecule techniques, protein crystallography, and cell biology, we will investigate how the mammalian tandem Coronin, Coro7, structurally and mechanistically inhibits Arp2/3-mediated nucleation induced by nucleation promoting factors (N- WASP, WHAMM, and JMY), and other Arp2/3 regulators, including GMF, and SPIN90. In addition, we will elucidate how these actin-regulatory activities of Coro7 work in concert with Arp2/3 and its various interactors in intracellular membrane transport and autophagy. Altogether, this proposal will shed light on the enigmatic actin-regulatory functions of the class of the tandem Coronins in vitro, and in cells.

PI_NAMEs: JANSEN, SILVIA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Actin-Binding Protein;Actins;Address;Adhesions;Affect;Automobile Driving;Autophagocytosis;Autophagosome;Binding;Biochemical;Biological Assay;Biological Process;Biophysics;cell motility;Cell Physiology;Cell Shape;Cells;Cellular biology;Complex;coronin protein;Crystallization;Crystallography;Cytoskeleton;Data;Distant;Family;Fluorescence;Genetic;genetic regulatory protein;Glia Maturation Factor;Image;Imaging Techniques;immunological synapse formation;In Vitro;Individual;insight;interdisciplinary approach;Intracellular Membranes;Learning;Length;live cell imaging;Lysosomes;Mediating;Membrane;Microfilaments;misfolded protein;Modeling;Molecular;Natural Immunity;Neurons;neurotransmission;Nutrient;Organelles;overexpression;Phagocytosis;Play;Process;Protein Biochemistry;Proteins;Pyrenes;reconstruction;Recovery;Regulation;Resolution;Role;Series;single molecule;spatiotemporal;Specificity;Speed;Surface;synergism;System;Tail;Techniques;Testing;Time;Total Internal Reflection Fluorescent;trafficking;Transmembrane Transport;Vesicle;Work;wound healing

PROJECT_TITLE: Regulation of membrane trafficking by Coronins

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: DURHAM

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Esthesioneuroblastoma is a rare tumor that arises in the nasal cavity and frequently causes patients to permanently lose their sense of smell. The biological pathways driving esthesioneuroblastoma growth remain poorly understood, and treatment options for patients have not improved for decades. This proposal aims to define mechanisms regulating proliferating cells in esthesioneuroblastoma and normal olfactory progenitors, with a goal of improving treatment strategies.

PI_NAMEs: FINLAY, JOHN BARRATT (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Adjuvant;Age related pathologies;Anosmia;Anterior;Area;ATAC-seq;Automobile Driving;Basal Cell;biocomputing;Biological;Biological Assay;Brain;cancer type;career;Cell Differentiation process;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;Chemotherapy and/or radiation;Chromatin;Collection;Complex;COVID-19 associated anosmia;Custom;Data;Data Set;Development;Disease;driver mutation;Epigenetic Process;epigenetic regulation;Epithelial Cells;Epithelium;Excision;Fossa;Genes;Genetic Transcription;Goals;Growth;Human;human tissue;Immune;Immunotherapy;improved;inhibitor;insight;Invaded;Life;Lymphocyte;Lymphocytic Infiltrate;Maintenance;Malignant Neoplasms;Maps;Medical;Mentorship;Modification;Molecular;Molecular Target;Morbidity - disease rate;mouse model;multiple omics;Mus;nano-string;Nasal cavity;Neoadjuvant Therapy;neurogenesis;Neuronal Differentiation;Neurons;new therapeutic target;Nose;novel;novel therapeutics;Ocular orbit;Olfactory Epithelial Cell;Olfactory Epithelium;olfactory neurogenesis;Operative Surgical Procedures;Organ;Outcome;Paraffin Embedding;Pathologic;Pathology;Pathway interactions;patient population;Patients;Peripheral;pharmacologic;Play;Polycomb;Population;post-COVID-19;preservation;Process;progenitor;Proliferating;Proliferation Marker;Proteins;Proteomics;Publishing;rare cancer;Recurrence;Research;Resected;Resolution;Role;Sampling;Scientist;Signal Transduction;skull base;Smell Perception;Spatial Distribution;Specific qualifier value;Specimen;Stains;stem cell niche;stem cells;Surgeon;Techniques;Technology;Therapeutic;Tissue Embedding;Training;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment strategy;tumor;tumor growth;Tumor Promotion;Tumor Tissue;Tumor-Derived;Undifferentiated;Up-Regulation;Variant;Work

PROJECT_TITLE: Leveraging multi-omics to define the role of epigenetic regulation by PRC2 in Esthesioneuroblastoma


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE We aim to train the next generation of addiction scientists to become rigorous and creative investigators to understand, treat and prevent drug abuse. Our goal is to provide pre- and post-doctoral trainees with both specialized research training in their chosen discipline, and also give them an appreciation for the broader issues related to addiction and addiction-related research, from molecular to policy. We have an experienced and dedicated team of researchers, in a rich and collaborative academic environment.

PI_NAMEs: HEDEKER, DONALD  (contact);ZHUANG, XIAOXI

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TITLE: Integrative Training in the Neurobiology of Addictive Behaviors


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: PROJECT NARRATIVE Women who enter pregnancy with obesity are more likely to experience pregnancy complications, such as gestational diabetes, hypertension, and babies born with obesity. Currently, weight management programs during pregnancy focus on helping women with obesity gain between 5 and 9 kg. However, these programs have not prevented many adverse health outcomes. This research project will determine the health effects and safety of a program to promote weight maintenance during pregnancy in women with severe obesity. If effective, the program has the potential to prevent many health problems in women who enter pregnancy with severe obesity and may also improve the health of their children.

PI_NAMEs: PHELAN, SUZANNE ;REDMAN, LEANNE MAREE (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: 37 weeks gestation;Adherence;Adverse event;Agreement;Behavior Control;Birth;Birth Weight;Black race;Blood Pressure;Body Composition;Body Water;Body Weight Changes;Body Weight decreased;Breast Feeding;Caloric Restriction;cardiometabolic risk;cardiometabolism;Cesarean section;Child;clinical care;clinically significant;Data;depressive symptoms;Desire for food;Dietary intake;dieting;effective therapy;efficacy testing;energy balance;epidemiologic data;epidemiology study;Ethnic Origin;excessive weight gain;experience;Fatigue;Fatty acid glycerol esters;fetal;Fetal Growth;Fetal Growth Retardation;Food;Gestational Diabetes;gestational weight gain;Glucose;Goals;Growth;Guidelines;Health;Healthcare;Hispanic;Hunger;Hypertension;improved;Incidence;Infant;innovation;Insulin;Intake;Intervention;lifestyle intervention;Lipids;maternal obesity;maternal weight;Measurement;Measures;Mediator;Modeling;Monitor;Morbid Obesity;Morbidity - disease rate;Neonatal;novel;Obesity;obstetric outcomes;Outcome;parity;Pattern;Physical activity;Placenta;Postpartum Period;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Trimesters;pregnant;Pregnant Women;preservation;prevent;programs;Prospective, cohort study;Race;Randomized;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Reporting;Research Project Grants;restraint;Risk Factors;Safety;Second Pregnancy Trimester;Small for Gestational Age Infant;Testing;therapy design;Third Pregnancy Trimester;Translating;treatment as usual;Weight;Weight Gain;weight maintenance;Weight maintenance regimen;Woman;women's treatment;Women's trial

PROJECT_TITLE: Promoting fat loss during pregnancy in women with grade 2 and 3 obesity

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]