ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Americans over age 65 are the largest group of patients and survivors of cancer in the U.S. and are also the most likely to experience sub-optimal treatment outcomes. Assessment of these factors, as part of a clinical exam, can help reduce risk. However, assessment and documentation of age-related risk is not well- coordinated, putting older adults at greater risk, especially diverse older patients such as those with limited English proficiency. The proposed project seeks to examine medical record and multi-level factors that can improve assessment of age-related risk and documentation with a broader goal of improving treatment planning and care for diverse older adults with cancer.

PI_NAMEs: SCHIAFFINO, MELODY K (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adult;Affect;age effect;age related;Aging;algorithm development;Algorithms;American;Award;Bioinformatics;Biometry;cancer care;Cancer Center;cancer health disparity;cancer risk;Cancer Survivor;cancer therapy;cancer type;care coordination;care delivery;care fragmentation;career;career development;Caring;Cities;Classification;Client satisfaction;Clinic;Clinical;Clinical assessments;clinical decision-making;clinical examination;clinical implementation;clinical practice;Clinical Trials;Communication;Comprehensive Cancer Center;Data;Data Science;Data Set;Decision Making;Dedications;demographics;design;Development;Diagnosis;Disease;Disparity;diverse data;Doctor of Philosophy;Documentation;Education;Elderly;Electronic Health Record;English Language;Ensure;Epidemiology;Equity;evidence base;experience;Face;Faculty;Future;Geriatric Assessment;Geriatrics;Gerontology;Goals;health disparity;health equity;Health Services Research;Health Status;Health system;human old age (65+);implementation science;improved;information gathering;Interview;K-Series Research Career Programs;Knowledge;Language;Limited English Proficiency;Location;Machine Learning;Malignant Neoplasms;medical examination;Medical Records;medical specialties;Medicine;member;Mentors;Methods;Minority;Natural Language Processing;older adult;older patient;Oncologist;Oncology;oncology program;Outcome;patient health information;patient-clinician communication;Patient-Focused Outcomes;Patients;Pattern;Persons;predictive modeling;Prevalence;Process;professor;Provider;Quality of Care;Radiation;Radiation Oncology;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Risk Reduction;routine practice;Scientist;screening;Series;shared decision making;skills;Specific qualifier value;Survivors;Symptom Burden;symptom treatment;System;tenure track;Testing;Time;tool;Training;Translational Research;Treatment outcome;treatment planning;Treatment-related toxicity;Uncertainty;Universities;unstructured clinical data;unstructured data;Variant

PROJECT_TITLE: Improving age-related risk assessment and documentation for diverse older adults with cancer

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

ORG_CITY: FREDERICK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

ORG_STATE: MD

PI_NAMEs: ALBERT, SARA  (contact)

PROJECT_TERMS: Acceleration;Africa;Cardiovascular Diseases;Chronic Disease;Clinical Research;co-infection;Disease Progression;Epidemiology;HIV;HIV Infections;Kidney Diseases;programs;Role;treatment response

PROJECT_TITLE: HIV CLINICAL RESEARCH IN WEST AFRICA


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: BETHESDA

ORG_NAME: TECHNICAL RESOURCES INTERNATIONAL, INC.

PI_NAMEs: CARAVOULIAS, CHRISTINA  (contact)

PROJECT_TERMS: Amendment;Cancer Therapy Evaluation Program;Cancer Trials Support Unit;clinical development;Clinical Trials;Communication;Contractor;Contracts;Goals;Letters;Process;programs;Protocols documentation;Research Personnel;Standardization;Time;Writing

PROJECT_TITLE: TASK ORDER 5A: CENTRALIZED PROTOCOL WRITING SUPPORT; CONTRACT TITLE: CANCER TRIALS SUPPORT UNIT CTSU.


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Treating dental caries infections is a massive healthcare expense due to the high number of cases to remove oral plaque, and mature biofilms are resilient to clinically available antibiotics due to their intricate architecture and strong binding to the hydroxyapatite coating of the enamel. Reported natural antibiofilm agents, such as isolates from Morus alba leaves and plant lectins, have shown moderate antibiofilm activity for S. mutans by targeting glucosyltransferases, yet natural product isolation can be time-consuming and expensive. Since there are no effective antibiofilm therapies provided in clinic, there is a demand for the development of antibiofilm agents that target a signaling pathway of S. mutans and other pathogenic bacteria while keeping the oral microbiome intact.

PI_NAMEs: ROJAS, EDWIN M (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: 3-Dimensional;Actinobacillus actinomycetemcomitans;Actinomyces naeslundii;Active Sites;Affect;Affinity;Anaerobic Bacteria;analog;Antibiotics;Architecture;Bacteria;beneficial microorganism;Binding;Binding Proteins;Biological;Biological Assay;Clinic;Clinical;Code;commensal bacteria;commensal microbes;confocal imaging;Consumption;cost;dental biofilm;Dental caries;Dental Enamel;design;Development;Dietary Sugars;Dinucleoside Phosphates;Disease;Docking;Down-Regulation;Enzymes;Etiology;Evaluation;experimental study;Genes;Genotype;Glucans;glucosyltransferase B;Glucosyltransferases;Glycolysis;Goals;Growth;HA coating;Healthcare;improved;in silico;In Vitro;in vitro Assay;Infection;inhibitor;Lactic acid;lead optimization;Marketing;meter;Microbe;Microbial Biofilms;Modeling;Morus;nanomolar;Natural Products;novel;novel strategies;novel therapeutics;Oral;oral bacteria;Oral cavity;oral commensal;oral microbiome;oral plaque;pathogen;pathogenic bacteria;Pathogenicity;Periodicity;Plant Lectins;polymicrobial biofilm;prevent;Prevention;Production;Radiolabeled;Reporting;resident commensals;resilience;Resistance;Saliva;screening;Signal Pathway;small molecule;Streptococcus;Streptococcus gordonii;Streptococcus mutans;Streptococcus sanguis;Structure;Structure-Activity Relationship;Surface Plasmon Resonance;targeted agent;Testing;Time;Tooth Demineralization;tooth surface;transcription factor;Transferase;Virulence;Water;Widespread Disease

PROJECT_TITLE: Streptococcus mutans diadenylate cyclase: A promising target for preventing dental caries

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cardiovascular;Dental, Oral, and Craniofacial Disease;Heart Disease;Infectious Diseases;Microbiome;Prevention

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Streptococcal species, such as S. mutans and S. gordonii, are known to cause or contribute to infections of the oral cavity such as caries and periodontal diseases using surface proteins to adhere to tissues for colonization and infection. A streptococcal-specific set of surface proteins, the AgI/II-family, have been shown to adhere to a range of human extracellular matrix proteins, other microbes, and components of the biofilm such as dextran. Directly interrupting adhesion to these targets would offer an antibiotic-fee treatment option to prevent infections of the oral cavity as well as preventing their contribution to infections of vital organs where AgI/II proteins contribute to disease.

PI_NAMEs: MIEHER, JOSHUA LEE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Abscess;Address;Adherence;Adhesions;Affinity;Agglutinins;Antibiotics;Antigens;Apical;Area;Bacteria;Bacterial Adhesins;Binding;Binding Sites;biofilm species;Biological;Biological Assay;Blood;Brain;C-terminal;Calcium ion;Calorimetry;Candida albicans;Cardiovascular system;Cell Wall;Characteristics;Clinical;Co-Immunoprecipitations;Collagen;cystic fibrosis infection;dental agent;Dental Care;Dental caries;design;Development;Dextrans;Dimensions;Disease;Dose;Etiology;Extracellular Matrix;Extracellular Matrix Proteins;Family;Fellowship;Fibrinogen;Fibronectins;glycoprotein 340;Goals;Growth;Heart;Heart Valves;Homologous Gene;host-microbe interactions;Housing;Human;Immunofluorescence Microscopy;Immunoglobulin Domain;In Vitro;Infection;Infection prevention;Infective endocarditis;Infiltration;Inflammation;inhibitor;Interruption;Invaded;Knock-out;Length;Liver;Lung;member;Membrane Proteins;Meta-Analysis;Microbe;microbial;Microbial Biofilms;microorganism;Minor;Modeling;Molecular;mutant;nanomolar;opportunistic pathogen;Oral cavity;oral commensal;oral infection;oral streptococci;Organ;Pathogenicity;Peptides;Periodontal Diseases;Periodontitis;Play;prevent;Protein Family;Proteins;Pseudomonas aeruginosa;Pulmonary Cystic Fibrosis;Reporting;Role;Salivary;Scavenger Receptor Cysteine-Rich Domain;Site;Spleen;Stream;Streptococcus;Streptococcus gordonii;Streptococcus intermedius;Streptococcus mutans;Structure;Surface;Surface Plasmon Resonance;Therapeutic;Tissues;Titrations;treatment fees;Variant

PROJECT_TITLE: Multifunctional Roles of AgI/II Family Proteins


ADMINISTERING_IC: AA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Screening and Brief Intervention for Substance Misuse;Social Determinants of Health;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Project Narrative: This Stage II Randomized Efficacy Trial will compare the effectiveness of a theoretically informed and culturally responsive brief motivational intervention to a non-adapted brief intervention among non-treatment seeking Latinxs admitted for medical treatment of an injury who engage in at risk drinking or were drinking at the time of their injury. The culturally informed brief motivational intervention (CI-BMI) increases autonomous motivation to engage in protective drinking behavior and reduce alcohol problems while addressing barriers to help seeking and facilitating treatment utilization. This project will address the alcohol related health disparities and treatment inequities among Latinx who are more likely to experience alcohol problems yet less likely to receive treatment in order to reduce the negative public health impact of alcohol.

PI_NAMEs: FIELD, CRAIG A (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Acculturation;Address;Admission activity;Adopted;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol related problem;alcohol use disorder;alcohol-related injury;Alcohols;Behavior;behavior change;Behavioral Mechanisms;brief alcohol intervention;brief intervention;brief motivational intervention;community based participatory research;compare effectiveness;comparison intervention;Competence;Consumption;cultural values;Data Analyses;design;Dimensions;drinking;drinking behavior;Early identification;Effectiveness;efficacy testing;efficacy trial;Eligibility Determination;ethnic difference;experience;flexibility;General Population;Harm Reduction;Health Disparities Research;health disparity;help-seeking behavior;high risk drinking;Individual;injured;Injury;innovation;Intervention;Intoxication;Knowledge;Latinx;Lead;Mediator;Medical;Medical center;Meta-Analysis;Modification;Motivation;Outcome;Outcome Study;patient subsets;Patients;Population;primary outcome;Process;protective factors;Provider;psychologic;Public Health;Randomized;randomized trial;randomized, clinical trials;reduced alcohol use;Research;Research Support;response;Risk Factors;satisfaction;Science;secondary outcome;Self Determination;Stress;Testing;Texas;theories;Time;trauma care;trauma centers;treatment as usual;treatment disparity;treatment effect;Universities

PROJECT_TITLE: Stage II Efficacy Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities among Latinxs

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance Some types of hormonal contraception have been associated with an increased risk of adverse cardiovascular outcomes, but the safety of these contraceptives has not been well studied among people with sickle cell disease (SCD) even though they have an elevated risk for these outcomes. Further, people with SCD are more likely to have an unplanned pregnancy than the general population, but little is known about what factors affect contraceptive decisions in this population. Results from the proposed study would help inform patient-centered contraceptive counseling for people with SCD by evaluating the safety of different contraceptive methods and examining patient and provider factors that affect contraceptive choices.

PI_NAMEs: HOWARDS, PENELOPE P. (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: abortion;active comparator;Address;Affect;African ancestry;Age;Attitude;Belief;Birth;black women;Cardiovascular system;Caring;Characteristics;Chronic;Chronic Disease;Clinical;clinical practice;Confusion;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;court;Data;design;Diagnosis;Discrimination;Early Diagnosis;Electronic Health Record;Enrollment;Estrogens;experience;Face;falls;Family Planning;Financial Hardship;Formulation;Foundations;Future;General Population;Goals;Health;Health system;hormonal contraception;housing instability;improved;Injectable;Interview;Knowledge;life span;Link;Long-Term Effects;Methods;Modernization;Myocardial Infarction;National Institute of Child Health and Human Development;Outcome;Pain;patient oriented;Patients;Persons;Population;preference;Pregnancy;Progestins;Provider;provider factors;public health relevance;Publishing;Quality of Care;Quality of life;racial minority;Recommendation;Recording of previous events;Reporting;reproductive;Research;Risk;Safety;safety assessment;Services;Sickle Cell Anemia;social stressor;sociodemographics;socioeconomic disadvantage;Stroke;Structure;Surveys;unintended pregnancy;United States;venous thromboembolism;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Hormonal contraception choice and safety among people with sickle cell disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-D(90)S]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE The autonomic innervation of the heart provides regulatory roles in heart function. Here, we propose to develop a 3D microphysiological co-culture platform to better understand fundamental aspects of sympatho-cardiac interaction and reciprocal regulation and growth of cardiac and autonomic cells. We will also establish a human model of cardiac muscle disease with sympathetic neurons, which will provide novel insights into understanding neuromodulation of cardiac pathogenesis.

PI_NAMEs: KIM, DEOK-HO  (contact);KWON, CHULAN

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Affect;Animal Model;Area;Arrhythmia;arrhythmogenic cardiomyopathy;Autonomic nervous system;Basic Science;Cardiac;cardiac muscle disease;Cardiac Myocytes;Cardiac Output;Cardiomyopathies;Cell Nucleus;Cells;chronotropic;Coculture Techniques;cost effective;Data;Desmosomes;Development;developmental disease;Diabetes Mellitus;disease model;disease phenotype;Disease Progression;Disparity;drug testing;electric impedance;Electrodes;Electrophysiology (science);Etiology;Evaluation;Exhibits;Feedback;Gene Mutation;Genes;Genetic;Goals;Growth;Heart;Heart Diseases;heart function;heart innervation;Human;human disease;human embryonic stem cell;human induced pluripotent stem cells;human model;Impairment;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell derived cardiomyocytes;insight;Measures;Microelectrodes;Microfabrication;microphysiology system;Mitotic Cell Cycle;Modeling;Molecular;Monitor;multimodality;Muscle Cells;Myocardial Infarction;Natural regeneration;Neonatal;Nerve;nerve supply;Neurons;Neuropathy;neuroregulation;novel;novel therapeutics;optogenetics;Pathogenesis;Pathogenicity;patient derived induced pluripotent stem cells;Patients;Performance;Phenotype;Physiological;Physiology;Population;pre-clinical;Process;Property;Regulation;Reporter;Research;Resolution;Rodent;Role;Specific qualifier value;spheroids;Structure;Structure of superior cervical ganglion;Sudden Death;Sympathectomy;synaptogenesis;System;targeted treatment;Techniques;Testing;Therapeutic;tissue culture;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Microphysiological Model of Human Cardiac Sympathetic Innervation

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative (Public Health Relevance Statement) Copper is an essential metal nutrient that is required for physiological functions spanning respiration and metabolism to antioxidant defense. Loss of copper homeostasis resulting from a combination of genetics, environment, diet, and lifestyle is connected to diseases including cancer, heart and neurodegenerative diseases, and metabolic disorders like obesity and diabetes. We are developing new chemical reagents for copper imaging and proteomics in biological systems to help decipher how copper contributes to healthy and disease states and target copper-dependent disease vulnerabilities, focusing on the contributions of copper and oxidative stress in cancer.

PI_NAMEs: CHANG, CHRISTOPHER J. (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: activity-based protein profiling;Animal Model;Animals;Antioxidants;Binding;Biochemical;Biological;Biological Models;biological systems;Biology;bioluminescence imaging;Cell model;Cell Proliferation;Cells;Chemicals;chemoproteomics;Complex;Copper;Cysteine;design;Detection;Development;Diabetes Mellitus;Diet;Disease;Environment;Enzymes;Evaluation;Fluorescence;Fluorescent Probes;Genetic;Health;Heart Diseases;Homeostasis;hormone biosynthesis;Human;Image;imaging agent;imaging modality;imaging probe;In Vitro;in vivo;inhibitor;innovation;invention;Label;Lead;lead candidate;Life Style;Logic;luminescence;Malignant Neoplasms;Maps;Melanoma;Metabolic;Metabolic Diseases;Metabolism;Metals;Methods;Modality;Modeling;Monitor;Neurodegenerative Disorders;neurotransmitter biosynthesis;next generation;Noise;novel;Nutrient;Obesity;Oncogenes;Optics;Organelles;Output;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathology;Pathway interactions;Physiological;Physiological Processes;Physiology;Play;Prognosis;protein purification;Proteins;Proteomics;proteostasis;public health relevance;Puromycin;Reagent;receptor;Research;Research Personnel;Resolution;Respiration;Role;Sampling;screening;Signal Transduction;Site;Specificity;Stains;Structure;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;Visualization

PROJECT_TITLE: Chemical Probes to Study Copper Biology

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE This project will determine the disease-altering properties of high-intensity exercise by randomizing 150 cognitively intact, sedentary elders (ages 65-80 years) at genetic risk for Alzheimer’s disease into two groups: one engaged in a high-intensity home-based cycling program and the other engaged in their habitual level of physical activity. Both groups will be monitored over 18 months with cognitive testing and MRI brain scans serving as primary outcomes to determine the disease-altering characteristics of aerobic exercise. Successful translation and demonstration of the effectiveness of a scalable home-based exercise intervention capable of slowing disease course will transform AD treatment, improve patient outcomes and quality of life, and reduce healthcare costs.

PI_NAMEs: ALBERTS, JAY L.;RAO, STEPHEN MARK (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Aerobic Exercise;Age;Alzheimer's Disease;Alzheimer's disease risk;Applications Grants;Area;Brain scan;Budgets;Characteristics;Cognitive;cognitive testing;cost;design;Disease;Disease Progression;Effectiveness;efficacy evaluation;Elderly;Enrollment;exercise intensity;exercise intervention;Funding;Genetic Risk;Goals;Health Care Costs;Home;improved;inclusion criteria;Magnetic Resonance Imaging;meetings;Methods;metropolitan;Monitor;Older Population;parent project;Participant;Patient-Focused Outcomes;Physical activity;primary outcome;Process;programs;Property;Quality of life;Randomized;Randomized, Controlled Trials;recruit;Research Design;sedentary;Translations;Travel

PROJECT_TITLE: CYCLE-AD: Randomized Controlled Trial to Assess the Efficacy of Indoor Cycling in Slowing Disease Progression in Healthy Older Persons at Genetic Risk for Alzheimer's Disease


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neurosciences;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Glioblastoma is the most lethal form of primary brain cancer in adults and robustly infiltrated with tumor- associated macrophages (TAMs). In this proposal, we will explore the key signaling axis that participates in TAM reprogramming and promotes glioblastoma progression. We plan to develop therapeutics targeting TAM programming against this deadly disease.

PI_NAMEs: CHEN, PEIWEN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;CCL2 gene;CCL7 gene;Cell Culture Techniques;Cells;Clinical;Combined Modality Therapy;Cytometry;Data;Data Set;Diagnosis;Disease;druggable target;Epigenetic Process;Exhibits;Family;Fees;Flow Cytometry;G-Protein-Coupled Receptors;gain of function;Genetic;Genetically Engineered Mouse;Glioblastoma;Glioma;Goals;Growth;Immunofluorescence Immunologic;Immunotherapeutic agent;Impairment;In Vitro;in vivo;Infiltration;inhibitor;innovation;Knockout Mice;Knowledge;loss of function;Macrophage;Malignant neoplasm of brain;Mediating;Modeling;Molecular;monocyte;mouse model;Mus;Myeloid Cells;novel;novel therapeutic intervention;Pathway interactions;patient derived xenograft model;Patients;peripheral blood;pharmacologic;Phenotype;Population;pre-clinical;preclinical trial;Process;programs;Proteomics;receptor;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Specimen;Stat3 protein;stemness;System;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;Time;transcriptome sequencing;transcriptomic profiling;transcriptomics;Translational Research;translational study;tumor;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;Validation

PROJECT_TITLE: Targeting macrophage reprogramming in glioblastoma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative The discovery of circRNAs opens an entirely new window into mechanisms of neurodegeneration in Alzheimer’s disease and related dementias (AD/ADRD). This proposal seeks to identify and characterize disease-linked circRNAs and RNA-binding proteins (RBPs), and functional changes in circRNAs or circRNA- RBP interactions that modify ADRD neuropathology or neurodegeneration. Successful discovery of key circRNAs or circRNA-RBP interactions in aging human brains could uncover novel biomarkers, disease mechanisms, or therapeutic targets to diagnose, mediate, or prevent the progression of AD/ADRD.

PI_NAMEs: WOLOZIN, BENJAMIN L;ZHANG, XIAOLING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Aging;Alzheimer's disease related dementia;Binding;Binding Proteins;Binding Sites;Biology;Brain;Brain region;circular RNA;Code;crosslinking and immunoprecipitation sequencing;Data;Diagnosis;Disease;Elements;Evaluation;Exhibits;Experimental Designs;Frontotemporal Dementia;Functional disorder;Future;Genes;Genetic;Genome;Genomics;Human;Investigation;Link;Mediating;Messenger RNA;Methods;MicroRNAs;Modeling;Molecular;Mutation;Nerve Degeneration;Neurons;neuropathology;novel;novel marker;Nucleotides;Organoids;Pathology;Porifera;prevent;Process;Production;protein aggregation;Proteins;Proteomics;Recording of previous events;Regulation;Ribosomal RNA;RNA metabolism;RNA Splicing;RNA-Binding Proteins;synaptic function;tau Proteins;therapeutic target;Tissues;transcriptome sequencing;Untranslated RNA;Variant

PROJECT_TITLE: Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology


PHR: Project Narrative (Public Health Relevance Statement) Reversible oxidation and reduction of protein methionines is an emerging mechanism for maintaining cellular homeostasis, contributing to regulation of protein function, cell signaling, and antioxidant defense. Indeed, increased oxidative stress and/or decreased capacity for reduction of methionine sulfoxide to methionine is linked to life-span regulation, neurodegeneration, vascular diseases and thrombosis, and cancer cell proliferation. We are developing new chemical tools to probe methionine with high specificity in protein and proteome settings to identify, biochemically characterize, and provide new imaging reagents for redox- responsive methionine sites important to physiology and disease, particularly in metabolic and oncogenic proteins.

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: activity-based protein profiling;adduct;Amino Acids;Antioxidants;Biochemical;Biology;Biomimetics;cancer cell;Cancer cell line;Cell Fractionation;Cell Line;Cell model;Cell Proliferation;Cells;Cellular Metabolic Process;Chemicals;Chemistry;chemoproteomics;collaborative environment;Complex;Cysteine;Data;Data Set;design;desthiobiotin;Development;Disease;Drug Metabolic Detoxication;Ectopic Expression;Endowment;Engineering;Enzymes;Free Energy;Glucose;Glycolysis;Health;Homeostasis;Hydrogen Peroxide;Image;improved;innovation;inorganic phosphate;Isotopes;Knock-out;Label;life span;Link;liquid chromatography mass spectrometry;lung cancer cell;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Metabolic;Metabolism;Methionine;methionine sulfoxide;methionine sulfoxide reductase;Methods;model design;Modeling;multiple omics;mutant;Mutation;NADP;Neoplasm Metastasis;Nerve Degeneration;Neurodegenerative Disorders;Nitrogen;NMR Spectroscopy;novel;Oncogenic;oxaziridine;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;pancreatic cancer model;Pathologic;Pathology;Pathway interactions;Pentosephosphate Pathway;Phase;Physiological;Physiological Processes;Physiology;Post-Translational Protein Processing;predictive modeling;Property;protein function;protein purification;Proteins;Proteome;Proteomics;public health relevance;Pyruvate Kinase;Reagent;Regulation;Research Personnel;Resistance;Respiration;response;Shunt Device;Signal Transduction;Site;Specificity;Sulfoxide;Sulfur;Surface;Techniques;Testing;Thrombosis;Time;Tissues;tool;Training;Vascular Diseases

PROJECT_TITLE: Chemical Probes to Study Methionine Redox Biology


NIH_SPENDING_CATS: Hematology

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: No project 4 in grant document

PI_NAMEs: STOWELL, SEAN R (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: ABO blood group system;Grant;Immunity;novel strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 PPG-C (O2)]


PHR: No Project 5 listed in grant document


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: MISCELLANEOUS

PHR: PUBLIC HEALTH RELEVANCE: The study advances National Institute of Child Health and Human Development (NICHD) dissemination and implementation research priorities of community-based participatory studies to engage communities in prevention of violence and injury, improve quality of life and functional status after violence, and foster resilience. Findings will advance the science for large-scale implementation of technology-based safety interventions in settings of greatest need.

PI_NAMEs: DECKER, MICHELE R. (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: acceptability and feasibility;Adoption;Advocate;Affect;Area;arm;Attitude;Cellular Phone;Characteristics;Code;college;Communities;community engagement;Community Health;community organizations;Conflict (Psychology);Consolidated Framework for Implementation Research;Dangerousness;Data;Decision Aid;Disclosure;Dissemination and Implementation;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation hybrid;efficacy evaluation;experience;Faith;Female;follow-up;Fostering;Frequencies;functional status;Government;Health;Homicide;implementation determinants;implementation strategy;improved;Individual;Informal Sectors;informal support;Injury;innovation;Institution;International;Internet;Intervention;intervention effect;Interview;intimate partner violence;Justice;Kenya;Knowledge;Leadership;life span;Link;low and middle-income countries;Maintenance;meetings;Mental Health;Methods;mHealth;mobile computing;mortality;National Institute of Child Health and Human Development;Nature;Nongovernmental Organizations;organizational readiness;Outcome;outreach;Pathway interactions;physical conditioning;post-traumatic stress;prevent;Process;promote resilience;Protocols documentation;Public Health;public health relevance;Quality of life;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Recommendation;Research;Research Priority;resilience;Resource-limited setting;Resources;response;revictimization;Risk;Safety;Schools;Science;secondary outcome;Secure;Self Efficacy;Services;Severities;sexual and reproductive health;Sexual Health;Shame;Social Impacts;Source;structural determinants;Support System;Surveys;Survivors;System;Technology;technology intervention;technology validation;Training;Translating;Trauma;trend;underserved area;Universities;Violence;violence prevention;volunteer;web app;web site;Woman;Women's cohort;Women's Health

PROJECT_TITLE: Dissemination, Implementation, and Effectiveness of an Intervention to Prevent Intimate Partner Violence

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Narrative The activities of this grant represent a major upgrade in the technology to precisely analyze protein molecules from cells and the human body. From model systems and humans, proteins are measured from cell culture, cells, fluids, and solid tissue to better understand and detect mechanisms and markers of human disease. Technological improvements assist the collaborating clinical and research labs directly, but also the field of protein measurement science in general through robust programs for training, dissemination and community engagement.

PI_NAMEs: KELLEHER, NEIL L (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: age-related disease;American;anti-cancer research;Applications Grants;Area;Automobile Driving;Basic Science;Biological Models;Biology;Cell Culture Techniques;Cells;Chicago;Clinical;Clinical Research;Collaborations;community engagement;data streams;Development;Disease;Ensure;Environment;experience;Generations;Geographic Distribution;Grant;Heart Diseases;Human;Human body;human disease;Immunology;improved;innovation;Institution;interest;International;Investments;Letters;Liquid substance;Mass Spectrum Analysis;Measurement;Measures;Medical Research;Mission;Molecular;National Institute of General Medical Sciences;Neurology;new technology;operation;Phase;Post-Translational Protein Processing;programs;Protein Analysis;Proteins;Proteomics;Research;Resources;Role;Science;Solid;synergism;Technology;technology research and development;Tissues;Training;Training Activity;Training Programs;Translating;United States National Institutes of Health;Universities

PROJECT_TITLE: National Resource for Translational and Developmental Proteomics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(40)-P]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Telehealth

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Stagnant survival and relapse rates for adolescents and young adults with cancer are partially attributed to a modifiable behavior—nonadherence to cancer treatments. To address multiple calls from the NCI and other federal agencies for research targeting disparities in cancer treatment outcomes for this population, this K08 research will use novel real time mobile health methodologies to examine and intervene on the time-varying, contextual factors that influence daily oral chemotherapy adherence in adolescents and young adults with acute lymphoblastic leukemia. The proposed research and career development plan will yield critical multi-level data and a just-in-time adaptive intervention for nonadherence, with the potential for the investigator to advance adherence intervention science and improve clinical outcomes in adolescents and young adults with cancer.

PI_NAMEs: PSIHOGIOS, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: 6-Mercaptopurine;acceptability and feasibility;Acute Lymphocytic Leukemia;adaptive intervention;Address;Adherence;Adolescent and Young Adult;Adolescent and young adult cancer patients;behavior change;cancer health disparity;Cancer Patient;cancer therapy;career development;Caregivers;chemotherapy;Clinical;Conduct Clinical Trials;contextual factors;Data;design;Development;Development Plans;Dissemination and Implementation;Ecological momentary assessment;effective intervention;Environment;Fatigue;Feedback;Focus Groups;Goals;Health behavior;improved;Intervention;Knowledge;leukemia;Life;longitudinal design;Maintenance;Malignant Childhood Neoplasm;Mentorship;Methodology;Methods;mHealth;mHealth methodology;modifiable behavior;Motivation;multidisciplinary;novel;Oral;Outcome;Patient Recruitments;Patients;Phase;pilot test;Population;Preparation;randomized trial;Relapse;relapse prevention;Research;research and development;Research Personnel;Science;Scientist;Self Management;skill acquisition;skills;statistics;Targeted Research;technological innovation;Testing;theories;therapy adherence;therapy development;Time;treatment adherence;Treatment outcome

PROJECT_TITLE: Using Real Time Mobile Health Approaches to Understand and Promote Oral Chemotherapy Adherence in Adolescents and young Adults with Leukemia

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric

ORG_CITY: PHILADELPHIA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: No PHR

PI_NAMEs: TONG, WEI  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Admission activity;Adult;Area;Basic Science;Benign;Biomedical Research;career;Childhood;Clinical Sciences;Collaborations;Data;Dedications;Degree program;design;Development;Educational Curriculum;Elements;Environment;Epidemiology;Evaluation;Faculty;Fox Chase Cancer Center;Goals;Grant;Hematological Disease;Hematology;Hematopoiesis;High School Student;innovation;Institution;inter-institutional;interest;investigator training;Kidney;Kidney Diseases;Laboratories;life span;Manuscripts;Master of Science;Medical Students;Mentors;Mentorship;Minority Recruitment;Pediatric Hospitals;peer coaching;Pennsylvania;Philadelphia;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Recording of previous events;recruit;Research;Research Personnel;Research Training;Science;Site;skills;skills training;Talents;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Students;Universities;Urologic Diseases;Urology;virtual;Vocational Guidance;Work;Writing

PROJECT_TITLE: Training Core


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Individual aging is the outcome of biological configuration and socioeconomic conditions and experiences. Aggregate population aging alters individual aging as it generates conditions that affect social organization, health services, and macro-economic change. CDHA helps to investigate these issues as an innovative and flexible provider of research products, training, and infrastructure for sharing scientific insights.

PI_NAMEs: ENGELMAN, MICHAL  (contact)

PROGRAM_OFFICER_NAME: BRAUDT, DAVID BRUCE

PROJECT_TERMS: Advocate;Affect;Aging;aging demography;aging population;aging related;Architecture;Attention;Awareness;biodemography;Biological;Biological Markers;Biological Process;Biomedical Research;Birth Place;care delivery;Caring;Cognitive;Collaborations;college;Communities;computer infrastructure;Computer software;Data;data acquisition;Data Analytics;data centers;Data Collection;data enclave;data library;data resource;Data Set;Demography;design;Deterioration;Development;disability;Ecology;Economic Conditions;economic outcome;Economics;Educational workshop;Epidemiology;epidemiology study;Epigenetic Process;Evaluation;Event;experience;Extramural Activities;Faculty Recruitment;faculty support;Family;fetal programming;flexibility;Foundations;Future;gene environment interaction;Genetic Processes;Geography;Goals;Graduate Education;Growth;Health;health economics;Health Services;Health Services Research;Health Status;high risk;Hormonal;Hospitals;improved;Individual;Infrastructure;innovation;insight;Institution;interest;Knowledge;late life;Lead;Leadership;Letters;Life Cycle Stages;Link;Longitudinal Studies;microbiome;middle age;Monitor;mortality;multidisciplinary;Outcome;Pilot Projects;Play;Policies;Policy Maker;prenatal;Professional Organizations;Program Development;programs;Provider;Research;Research Activity;Research Assistant;Research Infrastructure;Research Priority;Research Project Grants;Research Support;Resources;response;Role;Rural;Science;Scientist;Secure;senescence;Services;Shapes;social;social organization;Social outcome;Social Processes;sociodemographic disparity;socioeconomics;symposium;Technology;Text;tool;Training;Training Programs;United States National Institutes of Health;Universities;Update;Variant;Vision;Visit;Wisconsin;Work

PROJECT_TITLE: Center for Demography of Health and Aging


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE We propose a strategy to develop an integrated-diagnostics tool for eventual clinical translation, which will enable enhanced predictive modeling of clinical outcome and diagnostic precision in 1st line immunotherapy for NSCLC, the choice of which has shown to have a large impact on patient survival during the course of cancer management since subsequent lines of treatment are increasingly less likely to be successful. Our radiomics signatures, combined with clinically established and emerging biomarkers, will result in increased precision for the management of patients selected for anti-PD1/PDL1 therapy by more accurately predicting who will benefit from therapy and detect response with more precision and earlier than currently possible.

PI_NAMEs: KATZ, SHARYN ;KONTOS, DESPINA  (contact)

PROGRAM_OFFICER_NAME: LIN, CHARLES

PROJECT_TERMS: Address;American College of Radiology Imaging Network;anti-PD-1;Biological Markers;Blood Vessels;cancer immunotherapy;Cancer Patient;Characteristics;circulating DNA;Clinical;Clinical Management;clinical predictive model;clinical translation;Clinical Trials;cohort;Cytotoxic Chemotherapy;Data;Data Set;Databases;Detection;Diagnostic;diagnostic tool;Early treatment;Eastern Cooperative Oncology Group;effective therapy;empowerment;Eye;Goals;Human;Image;Immunotherapeutic agent;Immunotherapy;improved;Individual;information gathering;Institution;Malignant Neoplasms;Multi-Institutional Clinical Trial;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;open source;Outcome;Patient Selection;patient stratification;Patients;Pattern;pembrolizumab;personalized diagnostics;personalized management;phenomics;Phenotype;Population;Prediction of Response to Therapy;predictive marker;predictive signature;programmed cell death ligand 1;programmed cell death protein 1;prospective;radiological imaging;radiomics;Research;response;Scanning;Selection for Treatments;software development;Standardization;Structure;Surface;therapeutic biomarker;Time;treatment response;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;user-friendly;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Predictive and Diagnostic Radiomic Signatures in Non-Small Cell Lung Cancer (NSCLC)on Immunotherapy

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: SANTA CRUZ

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA CRUZ

ORG_STATE: CA

PHR: PROJECT NARRATIVE Tumor cells invariably have defects in the biochemical mechanisms that regulate cell growth and division, so understanding how these processes work is vital to understanding and inhibiting cancer. This research is determining a molecular picture of how proteins control normal and cancer cell proliferation.

PI_NAMEs: RUBIN, SETH MICHAEL (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biochemical;Biological Assay;cancer cell;Cell Cycle;Cell Cycle Regulation;Cell division;cell growth;Cell Proliferation;Cells;Chromatin;Chromatin Structure;Complex;Defect;DNA biosynthesis;FOXM1 gene;Gene Expression;Genetic Transcription;Growth;improved;inhibitor;innovation;insight;Malignant Neoplasms;Mitosis;Molecular;neoplastic cell;Normal Cell;Pathway interactions;Phosphorylation;Phosphotransferases;Process;Proteins;Regulation;Research;structural biology;Structure;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Molecular Mechanisms of Cell Cycle Dependent Gene Expression

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Endocrine Disruptors;Foodborne Illness;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: OVERALL: PROJECT NARRATIVE We have identified six complex problems associated with Superfund chemical contaminants that have proven intractable to current methods, in consultation with the Center’s key stakeholders. Using biomedical and engineering approaches we aim to generate research findings that will help solve these problems in association with our community partners and US government and California stakeholders.

PI_NAMEs: SMITH, MARTYN T (contact)

PROGRAM_OFFICER_NAME: CARLIN, DANIELLE J

PROJECT_TERMS: Address;Arsenic;Basic Science;Biological;biological systems;Biometry;Birth;California;Chemical Exposure;Chemicals;Child;Chromium;Collaborations;Communities;community based participatory research;community engagement;community partners;Complementary therapies;Complex;Consultations;Data;data sharing;design;drinking water;early life exposure;Education;Engineering;Ensure;Environment;Environmental Engineering technology;Environmental Health;environmental justice;environmental toxicology;Evaluation;Exposure to;Face;Fetus;Fostering;Goals;Government;Growth;Guidelines;halogenation;Hazardous Waste Sites;Health;Immune system;improved;In Situ;Infrastructure;innovation;Knowledge;Laws;Learning;Location;Mentorship;Metals;Methods;Mothers;neighborhood disadvantage;novel;Outcome;perinatal outcomes;Pesticides;Poison;Policies;pollutant;Poly-fluoroalkyl substances;Pregnant Women;prenatal influence;Problem Solving;Process;programs;Public Health;Regulation;remediation;Research;Research Ethics;Resistance;Resources;Risk Assessment;Site;Soil;success;Superfund;superfund chemical;System;Technology Transfer;Time;tool;Toxic effect;Toxicology;Training;translational engagement;vaccine-induced immunity;Water;Water Pollutants;water quality;Work

PROJECT_TITLE: Toxic substances in the environment


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

PHR: PROJECT NARRATIVE The brain is a predictive organ: its memories of the past are used to adaptively guide behavior in anticipation of events that might occur seconds, minutes, hours, or longer in the future. This project will uncover how the brain can simultaneously represent anticipatory signals at multiple timescales, how these signals are influenced by top-down goals, and how they can guide future-oriented behavior. Understanding how hierarchical anticipation signals support behavior at a range of timescales will yield important insights into how flexible, future-oriented actions are planned and implemented in a constantly changing world.

PI_NAMEs: ALY, MARIAM  (contact);BALDASSANO, CHRISTOPHER

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Affect;Area;Behavior;Behavioral;Brain;Brain region;Cities;Computer Models;Creativeness;Data;Destinations;Development;Distant;Environment;Episodic memory;Event;expectation;experience;extrastriate visual cortex;flexibility;Functional Magnetic Resonance Imaging;Future;Generations;Goals;Hour;Human;Impairment;Individual;insight;Knowledge;Laboratory Study;Learning;Lesion;Link;Memory;Methods;Modeling;Movement;movie;Natural Language Processing;Neuropsychology;novel;Organ;Participant;Patients;Pattern;Play;Poetry;predictive modeling;prospective;recurrent neural network;Role;Route;Semantic memory;Semantics;Signal Transduction;simulation;spatiotemporal;Stimulus;Structure;System;Testing;theories;tool;Update;virtual reality environment;Visual;Visual Cortex;Visual System;visual tracking;Walking;Work

PROJECT_TITLE: Hierarchies of spatiotemporal anticipation in the human brain

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: NARRATIVE – OVERALL With an estimated 22,000 new cases and 14,000 deaths each year, cancer of the ovary, fallopian tube or peritoneum (termed “ovarian cancer” in this application) remains the most lethal of the gynecological malignancies. The Mayo Clinic SPORE in Ovarian Cancer provides support for translational research projects that are intended to have a rapid impact for ovarian cancer patients. Specifically, we will develop and test four novel therapeutic approaches designed to i) stimulate the immune system (Project 1), ii) introduce a Next Generation TOP1 inhibitor for ovarian cancer (Project 2), iii) repurpose the FDA-approved kinase inhibitor ceritinib as an ovarian cancer therapeutic (Project 3) and iv) provide a new form of adoptive immune cell therapy (Project 4).

PI_NAMEs: KAUFMANN, SCOTT H (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: Acceleration;Adjuvant;Adoptive Immunotherapy;Allogenic;Animal Model;anti-cancer research;Basic Science;Biochemical;Bioinformatics;Biological;Biometry;Biostatistics Core;Cancer Biology;Cancer cell line;Cancer Model;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;Carcinoma;career;cellular engineering;Cellular immunotherapy;Cessation of life;chimeric antigen receptor natural killer cells;Clinic;Clinical;Clinical Trials;Clinical Trials Cooperative Group;Collaborations;Complementary DNA;Data;Dendritic Cell Vaccine;Dendritic Cells;design;Development;Disease;DNA Repair Pathway;effective therapy;Enrollment;Epithelial ovarian cancer;FDA approved;follow-up;FOLR1 gene;Fostering;Funding;Future;Generations;Genes;Genomics;Goals;Grant;Homing;homologous recombination;homologous recombination deficiency;Immune;Immune response;Immune system;Immunologic Stimulation;Immunotherapy;improved;inhibitor;innovation;insight;kinase inhibitor;Leadership;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Mammalian Oviducts;Mediating;Mentors;Metformin;Methods;Minnesota;Mission;Mitochondria;mortality;mTOR Inhibitor;Natural Killer Cells;next generation;novel;novel therapeutic intervention;novel therapeutics;Organ;Ovarian;Pathway interactions;patient derived xenograft model;patient registry;Patients;Peer Review;Peptides;peritoneal cancer;Peritoneum;phase 1 study;Phase I Clinical Trials;phase I trial;phase II trial;Phenotype;Physiologic pulse;Pilot Projects;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;programs;Publications;Reactive Oxygen Species;Recurrence;Relapse;Research;research clinical testing;Research Personnel;Research Project Grants;Resistance;Resources;Respiration;safety testing;Serous;Signal Transduction;Survival Rate;taxane;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic Studies;Therapeutic Trials;TOP1 gene;transcriptomics;translational pipeline;Translational Research;translational research program;translational scientist;treatment response;tumor;tumor microenvironment;United States National Institutes of Health;Universities;Uterus;vaccine response;vaccine strategy;Vaccines;women's treatment

PROJECT_TITLE: Next Generation TOP1 Inhibition for the Treatment of Uterine Serous Carcinoma


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Genetics;Infectious Diseases;Natural Products

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Public Health Relevance Statement Nature continues to drive the design of new drug leads through the inherent capacity of naturally produced chemicals to treat human disease. New tools in genomics and synthetic biology now allow for the accelerated discovery and engineering of novel natural product compounds from microbes and their DNA. We propose to combine poorly studied biological resources, such as deep-sea marine microbes, with modern genome mining strategies to increase the prospects for the discovery of new drug leads.

PI_NAMEs: JENSEN, PAUL R;MOORE, BRADLEY S (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Actinobacteria class;Address;Anabolism;Antibiotics;antimicrobial;Aquaculture;Bacteria;Bacterial natural products;Bioinformatics;Biological;chemical group;Chemicals;Chemistry;Clinical;Cloning;Collaborations;Collection;Communicable Diseases;comparative genomics;Crude Extracts;deep ocean;design;design,build,test;Development;DNA;drug discovery;emerging antibiotic resistance;Engineering;Environment;Enzymes;Evolution;Expeditions;experimental study;Fractionation;Future;Gene Cluster;gene synthesis;Genes;Genetic;Genetic Transcription;Genome;Genomics;Gifts;Goals;halogenation;Human;human disease;Hybrids;innovation;insight;isoprenoid;Knowledge;Laboratories;Lactones;Lead;Learning;Link;Malignant neoplasm of brain;marine;Marine Sediment;Medicine;metagenome;Metagenomics;meter;Methods;Microbe;microbial;microbial genome;Microbiology;Mining;Modeling;Modernization;Natural product discovery;Natural Products;Natural Products Chemistry;Nature;novel;novel therapeutics;Oceanography;Oceans;Orphan;Peptide Hydrolases;Pharmaceutical Preparations;phase III trial;Productivity;programs;Proteasome Inhibitor;public health relevance;Research;resistance gene;Resources;salinosporamide A;Sampling;Science;screening program;Signaling Molecule;small molecule;synthetic biology;Synthetic Genes;Taxon;Techniques;Testing;Time;tool;Vanadium;Virulence;Virulence Factors

PROJECT_TITLE: Natural Product Genome Mining

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE To date there is no access to long-acting injectable (LAI) antiretroviral therapy (ART) – specifically long-acting cabotegravir and rilpivirine (LA-CAB/RPV) – in low- and middle-income countries outside of research studies. Our overall objective is to leverage a critical opportunity to determine the clinical and economic value of viral load, drug concentration and genotypic data in making clinical treatment decisions amongst adolescents and young adults in South Africa who would benefit from LA-CAB RPV. Understanding the durable value of LA- CAB/RPV among adolescents – and which adolescents would benefit most from this intervention – will be critical to convey to policymakers and international organizations negotiating for access as well as to global treatment strategies.

PI_NAMEs: NEILAN, ANNE  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrative Supplement;Adolescent;Adolescent and Young Adult;Adult;African;Age;antiretroviral therapy;Area;Clinical;clinical decision-making;Clinical Treatment;cohort;Cohort Studies;Computer Simulation;cost;cost effectiveness;Data;economic impact;economic value;Effectiveness;Enrollment;experience;Failure;follow-up;Formulation;Genotype;Health;high risk;HIV;improved;Individual;Injectable;insight;International;Intervention;Lead;low and middle-income countries;Mediation;Modality;Modeling;models and simulation;Monitor;novel;Opportunistic Infections;Oral;oral care;Outcome;parent grant;Participant;Pharmaceutical Preparations;Policies;Policy Maker;Population;Prevention strategy;Recording of previous events;Regimen;Reporting;Research;research study;Resistance;Retroviridae Infections;Risk;Safety;Sampling;South Africa;standard of care;symposium;treatment response;treatment strategy;Viral;Viral Load result;Viremia;Work

PROJECT_TITLE: Adolescent-tailored HIV treatment and prevention strategies in South Africa: projecting clinical benefits and value (Supplement)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Aging;Arthritis;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Services;Osteoarthritis;Pain Research;Patient Safety;Physical Activity

ORG_NAME: TUFTS MEDICAL CENTER

PHR: PROJECT NARRATIVE Current clinical practice guidelines issued by the American College of Rheumatology strongly recommend Tai Chi as an intervention for knee Osteoarthritis (OA). To date, however, critical gaps exist in the evidence regarding "real world" effectiveness and implementation of mind-body approaches for knee OA pain across multiple Health Care Systems. The proposed pragmatic trial will test whether remote Tai Chi can be deployed effectively across multiple Health Care Systems in management of knee OA. The results will facilitate widespread deployment of Tai Chi mind-body therapies across multiple health systems in the U.S.

PI_NAMEs: LAVRETSKY, HELEN ;ROSEEN, ERIC J;SAPER, ROBERT BRUCE;WANG, CHENCHEN  (contact)

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: Adoption;Advisory Committees;Affect;Ambulatory Care Facilities;American;Analgesics;Behavioral;Boston;California;Chronic;Clinic;clinical diagnosis;Clinical Practice Guideline;Clinical Trials;Clinical Trials Data Monitoring Committees;clinically significant;collaboratory;college;comorbidity;compare effectiveness;Data;Degenerative polyarthritis;design;digital;Dimensions;disability;Effectiveness;Electronic Health Record;Enrollment;Ethics;Exercise;Exhibits;experience;Florida;follow-up;Future;Geographic Locations;Health;health care service utilization;health related quality of life;Health system;Healthcare Systems;implementation strategy;improved;Individual;Informed Consent;Injections;innovation;Internet;Intervention;Interview;Knee;Knee Osteoarthritis;knee replacement arthroplasty;Leadership;Los Angeles;Massachusetts;Medical Care Costs;Medical center;Mental Health;Mind-Body Intervention;mind/body;Musculoskeletal;Ohio;older adult;Online Systems;Operative Surgical Procedures;organizational structure;osteoarthritis pain;Outcome;Pain;Pain interference;pandemic disease;Participant;Patient-Focused Outcomes;Patients;Persons;Pharmacotherapy;Phase;physical conditioning;Population;pragmatic trial;Procedures;programs;Provider;psychosocial;Quality Control;Randomized;randomized trial;Recommendation;recruit;reduce symptoms;remote delivery;Replacement Arthroplasty;Research Design;retention rate;Rheumatology;routine care;Selection for Treatments;Site;Structure;Surveys;System;Tai Ji;Technology;Testing;Time;Toxic effect;treatment group;treatment trial;trial comparing;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: Remote Tai Chi for Knee Osteoarthritis: an Embedded Pragmatic Trial


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Despite the increasing availability and effectiveness of antiretroviral therapy, HIV continues to be the greatest pandemic of the last 50 years — 70 million infected, 36 million currently living with HIV and over 1.8 million new infections, including over 180,000 new infant infections annually — so it is imperative to develop an effective population-based approach to reduce transmission. This proposal for the Leadership and Operations Center of the HIV Vaccine Trials Network, the collaboration of scientists at 64 clinical trial sites in 15 countries on 4 continents dedicated to developing a globally effective HIV vaccine, describes the marked advances in candidate vaccines to induce broadly neutralizing antibodies (bnAbs), the advances in bnAbs administered by injection at levels that can prevent infection, and the HVTN’s extensive programs in engaging both local communities and other scientists throughout the world working to stop the spread of HIV. The goal of the HVTN is to develop a vaccine or monoclonal antibody combination that will, either alone or in combination, reduce HIV acquisition in adults and children by more than 60 percent.

PI_NAMEs: BAROUCH, DAN H.;COREY, LAWRENCE  (contact);GRAY, GLENDA E;TOMARAS, GEORGIA DORIS

PROGRAM_OFFICER_NAME: CALDER, THOMAS JAMES

PROJECT_TERMS: Adult;Africa South of the Sahara;AIDS prevention;Antibodies;antiretroviral therapy;Behavioral Sciences;Biological Specimen Banks;Child;Clinical;Clinical Trials;Collaborations;Communities;community advisory board;Complex;computational platform;Country;data repository;Dedications;design;Effectiveness;efficacy evaluation;efficacy trial;Enrollment;Funding;Germ Lines;Goals;HIV;HIV prevention trials network;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Infant;infant infection;Infection;Infection prevention;Infrastructure;Infusion procedures;Injections;Laboratories;Leadership;Mediating;Mentors;Monoclonal Antibodies;neutralizing antibody;neutralizing monoclonal antibodies;novel;novel vaccines;operation;pandemic disease;participant enrollment;people of color;Persons;Phase;Physicians;population based;prevent;Prevention trial;Process;programs;Randomized;recruit;Regimen;Research;Sampling;Science;Scientist;Site;success;Training;transgender;transmission process;Tuberculosis Vaccines;vaccine candidate;Vaccine Clinical Trial;Vaccine Design;vaccine development;vaccine trial;vaccine-induced antibodies;Vaccines

PROJECT_TITLE: LOC:  HIV Vaccine Trials Network


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_NAME: NEW YORK BLOOD CENTER

PHR: Narrative Vaccines are efficient measures to prevent infections, a critical problem is that aging-associated changes in the immune system lead to decreased immunogenicity and clinical efficacy of most currently used vaccines; novel strategies that increase vaccination efficacy and specifically target the aged immune system are imperative. An essential facet of these efforts is the use of combinatory adjuvants that synergistically potentiate more effective vaccine-induced immune responses against various pathogens. Our goal is to deliver a novel, efficacious combination of innate cytoplasmic PRR adjuvants with rASP-1, a unique parasite protein adjuvant, that promotes protective long-lived adaptive responses and boosts efficacy of vaccines in aged populations.

PI_NAMEs: LUSTIGMAN, SARA  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adjuvant;Adult;age related;aged;aging population;aging related;Agonist;Allergic Disease;Anti-viral Response;Antibody Response;Antigens;asparaginase;Autoimmune Diseases;Automobile Driving;B-Lymphocytes;Biochemistry;Bioinformatics;Biology;Blood;CD34 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular Immunity;clinical efficacy;Collaborations;Communicable Diseases;CXCL10 gene;CXCR3 gene;Cytoplasm;Data;Dendritic Cells;Development;Disease;effectiveness evaluation;enzyme linked immunospot assay;experimental study;Fluzone;Frequencies;functional improvement;Funding;Future;Genes;Goals;Grant;Helper-Inducer T-Lymphocyte;Hematopoietic stem cells;Human;human data;human model;humanized mouse;IL6 gene;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunity;immunogenicity;Immunoglobulin G;immunological status;Immunologics;Immunology;improved;in vitro activity;in vivo;Inactivated Vaccines;Individual;Infection prevention;influenza infection;influenza virus vaccine;influenzavirus;interest;Interferon Type II;Interferons;Interleukin-10;Investigation;Lead;Ligands;Malignant Neoplasms;Measures;Mediator;Memory;Methods;microbial;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;National Institute of Allergy and Infectious Disease;Nature;neutralizing vaccine;novel;novel strategies;old mice;Older Population;Parasites;parent grant;parent project;Parents;pathogen;Pathway interactions;Pattern recognition receptor;peripheral blood;Pre-Clinical Model;prevent;programs;Proteins;Receptor Cell;Recombinants;Recording of previous events;Regulatory Pathway;response;seasonal influenza;Signal Transduction;Spleen;Subunit Vaccines;synergism;System;T cell response;T-Lymphocyte;Testing;TLR7 gene;transcriptomics;TSLP gene;type I interferon receptor;United States National Institutes of Health;Up-Regulation;Vaccinated;Vaccination;Vaccine Adjuvant;vaccine efficacy;vaccine formulation;vaccine immunogenicity;vaccine-induced antibodies;Vaccines;vaccinology;Validation;Work

PROJECT_TITLE: Restoring age-dependent vaccine unresponsiveness by a novel ASP-1 adjuvant combination


ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Project Narrative The University of Alabama at Birmingham (UAB) Center for AIDS Research (CFAR) Implementation Science hub will provide coaching and consultation support to scientists receiving NIH supplement grants aligned with the national Ending the HIV Epidemic (EHE) initiative that seeks to reduce new HIV infections by 75% by 2025, and 90% by 2030. Proposed activities are well aligned with NIH HIV/AIDS Research Priorities, most notably supporting research in the cross-cutting areas of “health disparities, behavioral and social sciences research, epidemiology, information dissemination, implementation sciences, and training,” and will be achieved via five specific aims centered on: 1. Coaching, 2. Consultation, 3. Dissemination, 4. Collaboration, and 5. Conducting a cross-hub IS pilot with other CFARs and AIDS Research Centers (ARCs) across the country.

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Alabama;Applications Grants;Area;Award;behavioral and social science;Caring;Clinical;Clinical Services;Collaborations;Communication;Communities;community engagement;Community Health;community setting;Consultations;Coordination and Collaboration;Country;Data Coordinating Center;Development Plans;Diagnosis;Educational workshop;Environment and Public Health;Epidemic;Epidemiology;Evaluation;Foundations;Funding;Generations;Goals;Grant;health care delivery;health disparity;health equity;HIV;HIV Infections;HIV/AIDS;implementation research;implementation science;implementation strategy;Individual;Information Dissemination;innovation;Knowledge;Learning;Logic;Measures;Methodology;Modeling;Outcome Measure;Pilot Projects;Play;Positioning Attribute;prevent;Prevention;programs;Protocols documentation;Public Health;public health research;Publications;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Research Support;Research Training;Resources;Robin bird;Role;Science;Scientist;Series;service delivery;Services;Site;social science research;success;System;Time;Training;United States Dept. of Health and Human Services;United States National Institutes of Health;United States Public Health Service;Universities;uptake;Walking;Work;working group

PROJECT_TITLE: IS Hub Renewal (Year 2)


NIH_SPENDING_CATS: Brain Disorders;Breastfeeding, Lactation and Breast Milk;Digestive Diseases;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: PROJECT NARRATIVE This project is relevant to public health and the mission of NICHD because it will 1) help determine the molecular mechanisms of how human milk improves neurocognitive development by reducing intestinal-, systemic-, and neuro-inflammation in preterm infants, and 2) validate relevant non-invasive human biomarkers for clinical use. Determining the precise mechanism(s) with validated non-invasive biomarkers can improve monitoring of mixed human milk and infant formula feedings in clinical settings and/or in homes to optimize neurocognitive development. This proposal addresses the NICHD Pediatric Growth and Nutrition Branch’s research priorities to 1) understand the lifetime impact of nutrition on … child growth and development; and 2) understand the composition and function of human milk.

PI_NAMEs: CHEN, YIMIN  (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: Achievement;Address;Affect;Biological Markers;Brain;Brain region;brain tissue;brain volume;Child;Childhood;Clinical;Clinical Practice Guideline;clinically relevant;Cognition;cognitive performance;Comparative Study;Complex;Confounding Factors (Epidemiology);Connexins;Development;Disease;Encephalitis;Ensure;Ethics;expectation;experience;feeding;fighting;Future;glial activation;Goals;Growth;Growth and Development function;gut inflammation;gut-brain axis;Histologic;Home;Human;Human Milk;Immune;Immune response;improved;Incidence;infancy;Infant;Infant Development;Infant formula;Inflammation;Inflammatory;inflammatory marker;innovation;intestinal barrier;Intestines;Investigation;Knowledge;Life;Literature;Live Birth;Measures;Methods;Mission;Molecular;Monitor;Motor;National Institute of Child Health and Human Development;Neonatal;Neurocognitive;neurodevelopment;Neurodevelopmental Deficit;neuroinflammation;Neurologic;nutrition;Observational Study;Outcome;Performance;Pilot Projects;Policies;Population;porcine model;premature;Premature Birth;Premature Infant;preservation;protein expression;Proteins;Public Health;Randomized;Regimen;Research;Research Priority;Serum;Shapes;System;systemic inflammatory response;T-Lymphocyte;targeted treatment;Tissues;tool;Translational Research;Urine;Variant;white matter;white matter injury

PROJECT_TITLE: Mechanistic investigation of human milk feeding on neurodevelopment: a comparative study using neonatal piglets and translatable biomarkers

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative The project will reveal the underlying molecular mechanisms for how OLFML3 triggers microglial infiltration in CLOCK/BMAL1-high GBM. Based on these mechanistic results, the project will develop novel therapeutic strategies targeting microglial infiltration with or without with immune checkpoint inhibitors for GBM.

PI_NAMEs: CHEN, PEIWEN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Affect;anti-CTLA4;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Antibodies;ARNTL gene;Binding Proteins;Biological Assay;CD8-Positive T-Lymphocytes;Cell Count;cell motility;Cells;Characteristics;chemokine;circadian;Clinic;Co-Immunoprecipitations;Combined Modality Therapy;Complex;cytokine;Cytometry;Data;density;Development;Diagnosis;effective therapy;Failure;gain of function;Genetic;Genetic Heterogeneity;Genetically Engineered Mouse;genomic profiling;Glioblastoma;Glioma;Goals;Growth;Heterogeneity;Immune checkpoint inhibitor;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Impairment;In Vitro;in vivo;Infiltration;innovation;Integrin alpha5beta1;Integrins;Knowledge;loss of function;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane Proteins;Metabolic;Microglia;migration;Molecular;mouse model;neoplastic cell;novel;novel strategies;novel therapeutic intervention;olfactomedin;Oncogenes;Pathway interactions;patient derived xenograft model;Patients;pharmacologic;Phase;Population;preclinical trial;programmed cell death ligand 1;Protein Array;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;recruit;Regulation;release of sequestered calcium ion into cytoplasm;Resistance;Role;Sampling;sensor;Signal Pathway;Signal Transduction;single-cell RNA sequencing;stem cell self renewal;stem cells;Subgroup;success;SYK gene;synergism;System;targeted treatment;Testing;Therapeutic;therapeutic target;transcriptomics;treatment strategy;tumor;tumor microenvironment;tumor progression;Validation

PROJECT_TITLE: Mechanism and therapeutic potential of microglia regulation in glioblastoma


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative  Synapses are connections between neurons that change dimensions during long-term potentiation (LTP) and depression (LTD), cellular mechanisms of synaptic plasticity that underlie learning. We have discovered that individual synapses have both functional active zones (AZs) and structural nascent zones (NZ) that can be converted to AZ during LTP. We propose a multidisciplinary approach involving slice physiology, optogenetics, glutamate uncaging, and novel three-dimensional electron microscopy to investigate how NZ and AZ dynamics during synaptic plasticity regulate the success of future plasticity with outcomes promising new insights about learning and memory and new targets for understanding and treating learning disabilities.

PI_NAMEs: HARRIS, KRISTEN M (contact);ZITO, KAREN

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TITLE: Synaptic plasticity mechanisms that protect and refine local circuits

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: EMS administered buprenorphine is a promising strategy to increase access to life saving, evidence-based addiction treatment and referral for ongoing OUD care. Current evidence for EMS initiated buprenorphine is promising but limited to small retrospective or nonrandomized prospective cohort studies. During this study period, we will develop a study protocol for prehospital EMS-initiated buprenorphine and linkage to care for patients with OUD presenting with an opioid or in acute opioid withdrawal

PI_NAMEs: CARROLL, GERARD ;D'ONOFRIO, GAIL  (contact);HSER, YIH-ING ;KEATING, ELIZABETH

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;addiction;adverse outcome;Buprenorphine;buprenorphine treatment;Caring;Consensus;Data;Effectiveness;effectiveness evaluation;Emergency Care;Emergency medical service;Emergency Medicine;Ensure;evidence base;Feasibility Studies;field study;Focus Groups;Healthcare Systems;Hospitals;Human Resources;implementation trial;Individual;Intervention;Life;Medical;Methods;Naloxone;Observational Study;Opioid;opioid overdose;opioid use;opioid use disorder;opioid withdrawal;Outpatients;Overdose;Overdose reversal;Patient Care;Patients;Persons;Pre-hospital setting;prevent;Process;Prospective, cohort study;Protocols documentation;Publishing;randomized trial;Research;service engagement;Site;Testing;treatment strategy

PROJECT_TITLE: EMS initiated Buprenorphine for Opioid Use Disorder


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framedwithin our project research theme of health equity.

PI_NAMEs: BARRY, MICHELE ;HARRIS, EVA ;KO, ALBERT ICKSANG (contact);MADHIVANAN, PURNIMA

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Allergy and Infectious Disease;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skills;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - NIAID - Tariq

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(58)-R]

SUFFIX: SC


PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low- and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Allergy and Infectious Disease;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skill acquisition;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - NIAID - Pouye

SUFFIX: SD


PHR: PROGRAM NARRATIVE This training program is specifically designed to train a new cadre of researchers and leaders to address major but as yet under-studied public health problems engendered by conditions prevalent in urban and rural informal human settlements (slums) of low and middle-income countries (LMIC). This training is relevant also to developed countries as informal settlements in the form of homeless encampments expand. Selected candidates will undergo field training on site in LMICs to develop new global health research skills framed within our project research theme of health equity.

PROJECT_TITLE: GHES - NIAID - Villasis

SUFFIX: SB


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative Alzheimer’s Disease, a neurodegenerative condition ultimately leading to cognitive decline and dementia, can present in a variety of time courses and symptoms in different individuals. We aim to explore the consequences on the function of brain cells of different variation in human DNA that contribute to Alzheimer, using a combination of work in cell culture, human tissue and analysis of large-scale information. Ultimately, this will allow us to characterize the mechanisms by which combinations of changes in DNA lead to different manifestations of the manifestations of Alzheimer.

PI_NAMEs: DE JAGER, PHILIP L (contact);ST GEORGE-HYSLOP, PETER HENRY

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Address;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Binding;Bioinformatics;Biological;Biological Assay;Biology;Blood;Brain;brain cell;Cell Culture Techniques;Cell model;Cells;Clinical;Clinical Data;clinical phenotype;Code;Collection;Complex;cytokine;Data;Data Analyses;data and analysis portal;data modalities;Data Set;Databases;Dementia;Disease;Disease Progression;DNA;enzyme activity;Epigenetic Process;Event;experimental study;Genes;Genetic Risk;Genetic study;Genetic Transcription;Genetic Variation;Genome;Heterogeneity;Human;human data;human DNA;human induced pluripotent stem cells;human tissue;Immunoprecipitation;Impaired cognition;Individual;induced pluripotent stem cell;knock-down;Knock-out;Knowledge;Label;Lead;Link;lipidomics;Mass Spectrum Analysis;Measures;metabolomics;Microglia;migration;Molecular;Multiomic Data;multiple omics;Nerve Degeneration;neuropathology;Nodal;novel;Nucleic Acid Regulatory Sequences;Onset of illness;Pathway interactions;Phagocytosis;PLCG2 gene;Predisposition;Proteins;Proteomics;Research;risk variant;Signal Induction;Site;small molecule;Susceptibility Gene;Symptoms;Time;tool;transcriptomics;TREM2 gene;Tyrosine Phosphorylation;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Alzheimer variants: Propagation of shared functional changes across cellular networks


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative – Public Health Relevance Statement Recent statistics on endometrial cancer incidence and mortality underscore the need to understand not only what is driving the increases in endometrial cancer, but also why Black females have a higher likelihood of developing the serous histologic subtype and much worse outcomes. The objective of this study is to create 20 new patient-derived organoid models of serous endometrial cancer using tumor specimens from Black patients and make these models available to the research community. Preclinical models that represent all patients is essential to define biological contributors to disparities in outcomes.

PI_NAMEs: BURKARD, MARK E (contact)

PROGRAM_OFFICER_NAME: BELIN, PRECILLA L

PROJECT_TERMS: Address;Administrative Supplement;Area;Asian;Atypical Endometrial Hyperplasias;Automobile Driving;biobank;Biological;black patient;Black Populations;Black race;black women;Blood specimen;Breast;Cancer cell line;Cancer Center Support Grant;Cancer Death Rates;Cancer Patient;Carcinoma;Catchment Area;Cells;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Management;Clinical Trials;Coculture Techniques;Collaborations;Colorectal Cancer;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;County;Data;Death Rate;Diabetes Mellitus;Diagnosis;Disease;Disparity;Dwarfism;Education;Endometrial;Endometrial Carcinoma;Endometrial Neoplasms;ethnic disparity;exome sequencing;experimental study;Female;Female Breast Carcinoma;Funding;geographic disparity;Goals;Grant;Health;health equity;Histologic;Histology;Holden Comprehensive Cancer Center at the University of Iowa;Immune;Immunotherapy;improved;In Vitro;Incidence;interest;Iowa;Iowan;Laboratories;Lesion;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;medical schools;Minority;Minority Groups;Modeling;molecular subtypes;mortality;Mutation;Operative Surgical Procedures;Organoids;Outcome;patient population;patient privacy;Patients;pembrolizumab;peripheral blood;Population;Positioning Attribute;Pre-Clinical Model;Prevalence;Primary Neoplasm;Privatization;Prostate;public health relevance;racial disparity;Regimen;Research;Research Personnel;Research Support;response;Serous;Socioeconomic Factors;Specimen;Stage at Diagnosis;statistics;Survival Rate;TP53 gene;treatment response;treatment stratification;Trust;tumor;Tumor Debulking;Tumor Suppressor Proteins;Underrepresented Minority;Universities;Uterus;White Women;Wisconsin;Women's mortality

PROJECT_TITLE: Preclinical models of serous endometrial cancer from diverse patient populations


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE While significant advances in global health have been achieved in recent decades, serious disparities in health outcomes persist, especially among children, adolescents and their adult caregivers. The proposed research training program in global health disparities research, entitled “Addressing the Research Capacity Gap in Global Child, Adolescent & Family Health Disparities Utilizing Implementation and Data Sciences among Vulnerable Populations in Resource-limited Settings (ACHIEVE)”, focuses on increasing dissemination and implementation (D&I) and data science research capacity in order to address global health disparities affecting children, adolescents and their adult caregiving families; and is designed for Medical Doctors and Post-Doctoral trainees from diverse backgrounds in the United States (including underrepresented minorities) and sub-Saharan Africa. The ultimate goal of the ACHIEVE program is to support the development of a cadre of early career researchers applying D&I and data science research methods to ensure that research on evidence-based practices, interventions, and policies are effectively translated to and used in real-world settings heavily affected by health disparities impacting children, adolescents, and the adults who raise them in low and middle-income countries.

PI_NAMEs: BETANCOURT, THERESA STICHICK;HUANG, KENG-YEN ;MCKAY, MARY MCKERNAN;SSEWAMALA, FRED M (contact);TOZAN, YESIM ;WEINE, STEVAN MERRILL

PROJECT_TERMS: Active Learning;Address;Adolescent;adolescent health;Adult;Affect;Africa South of the Sahara;Asia;burden of illness;Caregivers;Child;Child Health;cohort;Collaborations;Consultations;Country;Data Science;Dissemination and Implementation;dissemination science;Eastern Europe;Emerging Communicable Diseases;Ensure;Equity;Family;Family health status;Funding;global health;Goals;Graduate Degree;Health;health care disparity;health disparity;health inequalities;Health Professional;Healthcare Systems;Immersion;implementation science;Incidence;Knowledge;Learning;Light;low and middle-income countries;Mentors;Mentorship;Methodology;Monitor;Online Systems;Outcome;outcome disparities;Pattern;Population;Populations at Risk;Postdoctoral Fellow;programs;Public Health;Research;Research Methodology;Research Personnel;Research Training;Resource-limited setting;skills;Time;Training;Training Programs;Translations;trend;Universities;uptake;Vulnerable Populations

PROJECT_TITLE: Addressing the Research Capacity Gap in Global Child, Adolescent, & Family Health Utilizing Implementation and Data Sciences


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PROJECT_TERMS: Address;Africa;Arizona;Asia;California;career;Career Choice;career development;Caribbean region;Central America;Collaborations;Communicable Diseases;Communities;Country;Dedications;design;Discipline;Disease;doctoral student;Eastern Europe;Educational workshop;Environmental Health;Exposure to;Faculty;faculty mentor;global health;Health;health equity;Health equity research;HIV;Human;Inequity;Injury;Institution;Interpersonal Violence;low and middle-income countries;member;Mental Health;Mentors;Mentorship;Methods;multidisciplinary;Persons;Postdoctoral Fellow;pre-doctoral;programs;recruit;Research;Research Methodology;Research Personnel;Research Support;Research Training;Rural;Scholars Program;Site;skill acquisition;Slum;South America;Substance abuse problem;Supervision;Time;Training;Training Programs;Universities;Vulnerable Populations;Women's Health;Work

PROJECT_TITLE: GHES - OAR - Babirye

SUFFIX: SA


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Lung Cancer;Prevention;Rare Diseases;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health;Tuberculosis

ORG_CITY: BOSTON

PHR: SUPPLEMENT PROJECT NARRATIVE Clinical and public health strategies to reduce tobacco use are urgently needed in sub-Saharan Africa, where tobacco use is increasing and colliding with epidemics of HIV and tuberculosis. This project will evaluate the impact of brief telephonic tobacco cessation counseling and of a tobacco sales ban on tobacco use among people with and without HIV in rural South Africa.

PI_NAMEs: REDDY, KRISHNA P (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adult;Africa South of the Sahara;Age;antiretroviral therapy;Area;Behavior;Behavioral;Cardiovascular Diseases;Caring;Cause of Death;Cessation of life;Chronic;Clinical;Cohort Studies;Collaborations;Communities;Complement;Counseling;Country;Data;Disease;economic impact;economic outcome;Epidemic;Epidemiologist;Ethics;HIV;HIV/TB;Home;Improve Access;Income;Intervention;Intervention Studies;Life Expectancy;low and middle-income countries;Malignant Neoplasms;member;Modeling;multidisciplinary;National Institute of Drug Abuse;Outcome;Parents;Participant;Persons;pharmacologic;Policy Maker;Population;Positioning Attribute;Prevalence;programs;Public Health;public health intervention;reduce tobacco use;Reporting;Research;respiratory;Risk Factors;Rural;Rural Population;rural South Africa;Sales;Smoking;smoking prevalence;South Africa;Surveys;Telephone;telephone coaching;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco Dependence;Tobacco Industry;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;Tuberculosis;Urban Population;World Health Organization

PROJECT_TITLE: Tobacco Use and Cessation, HIV, and TB in South Africa: Clinical and Economic Outcomes (Clinical and public health approaches to tobacco cessation in South Africa supplement)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)]


ORG_STATE: AL

PHR: NARRATIVE The proposed research activities will contribute a fundamental, hyperlocal knowledge of HIV risk among persons who inject drugs in Alabama. This data is essential to identify and prioritize communities for HIV prevention services, in addition to harm reduction and addiction interventions. We will not reach the ambitious aims of the Ending the HIV Epidemic Initiative without tailoring prevention efforts to meet the needs of PWID, a group who is most marginalized and at heightened risk of HIV.

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute care;addiction;Address;AIDS prevention;Alabama;Bacterial Infections;Behavior;care systems;Caring;Communicable Diseases;Communities;community advisory board;community based participatory research;community building;community collaboration;community engagement;community partners;County;COVID-19;Data;Disease Outbreaks;Drug usage;Epidemic;Epidemiologic Methods;Epidemiologic Monitoring;Epidemiology;Event;Evidence based practice;Fentanyl;fentanyl test;Geographic Distribution;Goals;Harm Reduction;Health;Health Service Area;Hepatitis C virus;high risk;HIV;HIV diagnosis;HIV disparities;HIV risk;HIV/HCV;Hospitalization;Hospitals;implementation strategy;Infection;Infrastructure;Injecting drug user;Injections;integrated care;Intervention;Knowledge;Legal;Life;Maps;marginalization;Medicaid;Medical;Methamphetamine;Naloxone;Nature;novel;opioid overdose;opioid use disorder;Outcome;Overdose;pandemic disease;person centered;Pharmaceutical Preparations;Population;Positioning Attribute;Poverty;pre-exposure prophylaxis;Prevention;prevention service;primary care provider;primary medical care;Provider;Public Health;public health emergency;Qualitative Methods;Qualitative Research;Reporting;Research;Research Activity;Resources;return to use;Risk;Rural;rural counties;rurality;scale up;Scientist;service organization;Services;Site;substance use;Surrogate Markers;surveillance data;test strip;Time;transactional sex;Translating;treatment center;Viral Load result;Virus Diseases;Work

PROJECT_TITLE: Using Geospatial Mapping and Epidemiologic Methods to Identify and Support Persons who Inject Drugs (PWID) at risk for HIV in Alabama


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Lupus;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE Glucocorticoids are commonly prescribed as a short course in the treatment of autoimmune diseases such as lupus, lupus nephritis, rheumatoid arthritis, IgG4-related disease, and ANCA-associated vasculitis, whether as an induction therapy of a study regimen or as a permitted rescue medication for both disease-related and unrelated reasons. Protocols often apply strict criteria for tapering on a pre-specified time course and fixed stepwise reduction in dose levels to discontinuation. Common Data Elements (CDEs) to capture glucocorticoid administration do not exist in the NIH CDE Repository, and data representing the specifics of a glucocorticoid taper are crucial for analysis to understand patient benefit from this approach, would support deep learning, and could inform future approaches to recording intermittent use of concomitant medications.

PI_NAMEs: SCHMIDT, PETER N. (contact);SNYDER, CATHIE

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: ANCA vasculitis;Artificial Intelligence;Autoimmune Diseases;Budgets;Case Report Form;Clinical;Clinical Data;clinical training;clinically relevant;Common Data Element;Complex;Congresses;Consensus;Data;Data Collection;data management;Data Set;data standards;deep learning;Development;Disease;Dose;Education;efficacy evaluation;Ensure;Fostering;Future;Glucocorticoids;Health;Human;Human Resources;Hypersensitivity;IgG4-related disease;Immunology;improved;insight;Lupus;Lupus Nephritis;Machine Learning;Malignant Neoplasms;National Institute of Allergy and Infectious Disease;Neoadjuvant Therapy;Outcome;Participant;Patients;Pharmaceutical Preparations;Population;Preparation;prevent;programs;Protocols documentation;Recommendation;Regimen;Registries;Reporting;repository;Research Design;Rheumatoid Arthritis;Safety Management;Semantics;Services;simulation environment;Specific qualifier value;Testing;Time;Transplantation;United States National Institutes of Health;Validation

PROJECT_TITLE: RhoFED CDSMC