ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

PHR: PROJECT NARRATIVE The HIV epidemic disproportionately affects young adult gay, bisexual, and other men who have sex with men (YMSM; age 18-34), a population largely impacted by stigma (i.e., minority stress) and mental health issues, both create a “syndemic” condition surrounding sexual risk behaviors and suboptimal HIV testing. Mindfulness-based interventions (MBIs) are efficacious in reducing psychological distress and promoting behavioral health, and successful adaptation of MBI for content and internet-delivery may offer an innovative, transdiagnostic, and scalable approach to reach YMSM and address this public health issue. Using an evidence-based adaptation model (ADAPT-ITT) for HIV behavioral health, the current project aims to systematically adapt mindfulness-based stress reduction (MBSR), an empirically-supported intervention with efficacy, to the context of HIV prevention and minority stress reduction via internet-based delivery among distressed, high risk YMSM, followed by a randomized feasibility trial.

PI_NAMEs: SUN, SHUFANG  (contact)

PROGRAM_OFFICER_NAME: MUDD, LANAY MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Affect;Age;AIDS prevention;Anxiety;behavioral health;behavioral health intervention;Benchmarking;biological adaptation to stress;Biological Markers;biopsychosocial;Bisexual;career;Clinical;clinical development;clinical efficacy;clinical trial implementation;Clinical Trials;condomless anal sex;coping;Counseling;Data;design;Development;Diagnostic;diagnostic strategy;Disclosure;Discrimination;disorder prevention;Disparity;Distress;Educational workshop;efficacious intervention;efficacy study;emotion dysregulation;Epidemic;Evaluation;evidence base;experience;feasibility trial;Feedback;Focus Groups;Foundations;Funding;Future;Gays;Grant;Hair;Health;health disparity;Health education;Health Promotion;Health Services;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Home;Human immunodeficiency virus test;Hydrocortisone;improved;Impulsivity;Individual;innovation;Institution;internalized stigma;Internet;internet delivery;Intervention;intervention refinement;K-Series Research Career Programs;Lead;life span;Link;marginalized community;men who have sex with men;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;mindfulness;mindfulness intervention;Mindfulness Training;mindfulness-based stress reduction;Minority Groups;minority health;minority stress;Modeling;National Center for Complementary and Integrative Health;Patient Self-Report;Persons;Phase;Physiological;Physiology;pilot test;Population;population health;pre-exposure prophylaxis;Prevention strategy;preventive intervention;primary outcome;Process;Production;protocol development;Protocols documentation;Provider;psychological distress;psychological symptom;Public Health;Public Health Schools;Randomized;recruit;Research;research and development;Research Personnel;Resources;Risk;sample collection;Sampling;Scientist;Series;Sexual Health;sexual risk behavior;social stigma;Stigmatization;Stress;Stress and Coping;stress reduction;substance use;syndemic;Testing;Training;Underserved Population;Universities;Work;young adult;young men who have sex with men

PROJECT_TITLE: Developing Internet-Delivered, Mindfulness-based Intervention to Reduce HIV Risk and Promote Mental and Sexual Health among Young Adult MSM


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Maternal Morbidity and Mortality;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The Northwestern University Biostatistics Research Center (NU BRC) will serve as a central leadership hub for the Glycemic Profile of Pregnancy Consortium, coordinating all data-related and operational activities using cutting-edge resources for study design, planning and conduct, ongoing data monitoring and statistical analysis. The NU BRC will develop novel and clinically interpretable statistical models for continuous glucose monitoring data, and will investigate associations between maternal glycemia during early pregnancy with development of gestational diabetes and outcomes at delivery.

PI_NAMEs: SCHOLTENS, DENISE M (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Address;Adolescence;adverse pregnancy outcome;Area;Biometry;Birth;Birth trauma;Case Report Form;central database;Cesarean section;Charge;Child;Childhood;Clinical;clinical center;Clinical Trials;Communication;Continuous Glucose Monitor;Data;Data Analyses;data modeling;data quality;design;Development;Diabetes Mellitus;Diagnosis;diagnostic criteria;Dystocia;early pregnancy;experience;Faculty;fetal programming;follow-up;Follow-Up Studies;Generations;Gestational Diabetes;Glucose;glucose metabolism;Glucose Metabolism Disorders;High birth weight infant;high risk;Human Resources;Hyperglycemia;innovation;insight;International;Investigation;Laboratories;Lead;Leadership;Link;long-term sequelae;maternal hyperglycemia;Measures;meetings;member;Metabolic Diseases;method development;Methodology;Modeling;Monitor;Mothers;Multicenter Studies;multiple data types;National Institute of Diabetes and Digestive and Kidney Diseases;newborn adiposity;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Observational Study;offspring;Outcome;Outcome Study;perinatal outcomes;perinatal period;Population Research;Pregnancy;Pregnancy Complications;Pregnancy in Diabetics;Pregnant Women;Procedures;protocol development;Publications;Qualifying;quality assurance;Reproducibility;Research;Research Design;Resources;Risk Factors;Role;Sampling;screening;sensor;Shoulder;Statistical Data Interpretation;Statistical Models;Structure;Technology;Translations;Universities;Work

PROJECT_TITLE: Glycemic Profile of Pregnancy Consortium Biostatistics Research Center


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Narrative This project will use emerging, state-of-the-art optical technology to characterize, with unprecedented detail, neural processes that contribute to conscious, visual experience. This work will separate mechanisms related to perception from these related to sensory encoding and behavioral report in thousands of type-specific neurons across all brain areas relevant for vision in laboratory mice and test their mechanistic value. These results will reveal mechanistic targets for new treatments of disorders such as coma and spatial neglect, which severely damage experience and have no viable treatments currently available.

PI_NAMEs: REDINBAUGH, MICHELLE JORDAN (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Agreement;Anesthetics;Animal Behavior;Animal Model;Appearance;Area;area striata;Behavior Control;Behavioral;Behavioral Assay;Biological Assay;Brain;Brain Stem;Calcium;cell type;Cells;Cerebral hemisphere;Clozapine;Coma;Communication;Complex;Conscious;Consciousness Disorders;Consensus;Data;Decision Making;design;designer receptors exclusively activated by designer drugs;Detection;Disease;Emerging Technologies;Event;experience;extrastriate visual cortex;Feedback;General Anesthesia;genetic manipulation;Genetic Techniques;Goals;Hallucinations;Health;hippocampal pyramidal neuron;Image;Imaging Techniques;Individual;Injections;instrument;instrumentation;Laboratory mice;Life;Link;Lived experience;Machine Learning;Macular degeneration;Medical;Microscope;Microscopic;Modality;mouse model;Mus;Nature;neural;neuroimaging;neuromechanism;Neurons;new technology;Operative Surgical Procedures;Optical Illusions;Optics;Outcome;Oxides;Parietal Lobe;Patients;Pattern;Perception;Photons;Play;prevent;Process;Property;Psychometrics;Pulvinar structure;Recurrence;Reporting;Research;Resolution;Retina;Risk;Rodent;Role;Sensory;sensory mechanism;Signal Transduction;spatial neglect;Specificity;Stimulus;Stroke;Structure;Study models;Syndrome;synthetic drug;System;Techniques;Technology;Testing;Thalamic Nuclei;Thalamic structure;theories;Time;Training;Transgenic Mice;Trauma;Trauma patient;Vision;Visual;Visual Cortex;Visual Perception;visual stimulus;voltage;Work

PROJECT_TITLE: Large-scale calcium and voltage imaging to illuminate neural mechanisms of visual experience


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE  Synaptic connections between neurons form the basis of network connectivity in the brain, and synaptic plasticity is widely believed to underlie adaptive behavior and learning. However, the dynamic range and modulation of synaptic strength in vivo is essentially unknown, raising a major challenge to our understanding of nervous system function. Here, we combine conceptual and methodological innovations to drive a pioneering exploration of the relationship between synaptic transmission and ongoing behavior.

PI_NAMEs: HIGLEY, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adaptive Behaviors;adaptive learning;Animals;Area;Behavior;Behavioral;Brain;Communities;Data;Goals;in vivo;innovation;insight;Laboratories;Learning;Methodology;Modification;Molecular;Monitor;Mus;Neocortex;Nervous System;Nervous System Physiology;Neurons;Neurosciences;Perceptual learning;Probability;Process;Property;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Time;Variant;Visual Cortex;visual motor

PROJECT_TITLE: Bridging cellular and systems neuroscience: synaptic dynamics underlying behavior


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative The genomic and phenotypic complexity of malignant glioma has been implicated as the root causes of most treatment failure. Long-term goal of our research program is to develop strategies to model, predict, and target therapeutic sensitivity and resistance of glioblastoma. This research plan is articulated around the development of a novel and integrated computational-experimental framework for the dissection of biologically homogeneous subgroups of glioblastoma, the study of cancer heterogeneity at the single cell level that will inform on the irreplaceable tumor cell-specific core pathways and the therapeutic exploitation of synthetically lethal driver modules.

PI_NAMEs: IAVARONE, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Articulation;Biological;Brain Neoplasms;cancer genome;cancer heterogeneity;Cancer Model;Cancer Patient;Cells;Classification;Clinical Research;Computer Analysis;computerized tools;Dependence;design;Development;Dissection;drug sensitivity;Genes;Genomics;Glioblastoma;Goals;high throughput technology;Human;in vitro Model;in vivo;Individual;innovation;Investigation;Laboratories;Malignant Glioma;Malignant Neoplasms;Modeling;Molecular;Motion;neoplastic cell;new technology;new therapeutic target;novel;Oncogenes;Oncogenic;operation;Outcome;Pathogenesis;Pathway interactions;Patients;personalized therapeutic;Phenotype;programs;Proteins;Proteomics;Research;Resistance;Route;Solid Neoplasm;Stratification;Subgroup;targeted treatment;Testing;Therapeutic;therapeutic target;Tissues;tool;transcriptomics;Treatment Failure;tumor;Universities;Validation;Work

PROJECT_TITLE: Oncogenic mechanisms, molecular stratification and therapeutic targets of brain tumors


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease

ORG_CITY: SAN FRANCISCO

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Enzymes are central to biology and a physical understanding of enzyme function in vitro and in vivo has far- reaching implications in medicine and industry. Here we will leverage adaptive evolution and high-throughput technologies to build the first map between enzyme sequence, enzyme function and organism fitness. This sequence-function-fitness map will allow us to address many important questions in biochemistry and evolution and will usher in a new era of integrative biochemical evolution studies.

PI_NAMEs: PINNEY, MARGAUX  (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Active Sites;Address;Affect;Amino Acid Sequence;anti-cancer;Anti-viral Agents;antimicrobial;Appointment;Area;Award;Bar Codes;Basic Science;Benchmarking;Biochemical;biochemical evolution;Biochemistry;Biological;Biological Assay;Biological Markers;Biology;Biophysics;Bioremediations;catalyst;Cell Therapy;Cells;chemical reaction;Chemicals;Chemistry;Collaborations;Communities;Complex;computing resources;Data;Data Set;Dedications;design;Discipline;Doctor of Philosophy;Environment;enzyme mechanism;Enzymes;Evolution;experience;Faculty;faculty mentor;fitness;frontier;Future;genetic variant;Goals;graduate student;high throughput technology;HRK gene;human pathogen;improved;In Vitro;in vivo;Individual;Industry;Institution;interest;Investigation;Knowledge;Laws;Lead;Learning;Libraries;Life;Link;macromolecule;Maps;Measurement;Measures;Medicine;Mentors;Mentorship;Metabolic Diseases;Methods;microfluidic technology;Modeling;Molecular;Molecular Evolution;Mutation;next generation;novel;Organism;Pathogenesis;Pharmaceutical Preparations;Physics;Positioning Attribute;Postdoctoral Fellow;precision medicine;Predisposition;pressure;Property;protein function;Proteins;Publications;recruit;Regulation;Research;Research Proposals;response;senior faculty;Specific qualifier value;Specificity;Structure;Techniques;Technology;Temperature;Testing;Therapeutic;tool;Translating;Translational Research;undergraduate student;Variant;Virulence;Work

PROJECT_TITLE: Leveraging Adaptive Evolution and High-Throughput Techniques to Dissect the Link Between Biochemical Function and Fitness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Auditory categorization is essential for survival in the animal kingdom and speech comprehension in humans. This project aims to quantify differences between excitatory neural subpopulations, as well as how learning shapes their role in auditory-guided behaviors. Studying these specific cell-types in greater detail could bring about new theories of information processing, neural coding, and learning, providing a foundation for understanding numerous cognitive and behavioral disorders.

PI_NAMEs: SCHNEIDER, NATHAN A (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TITLE: Learning-induced changes in distinct auditory cortical cell-types


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: At-risk alcohol use, alcohol use disorder and return to drinking can have negative impacts on people with HIV (PWH). We propose to integrate alcohol reduction and relapse prevention interventions into HIV clinical care settings and to study the long-term effects of the spectrum of alcohol use on the alcohol and HIV care continua, comorbidities and disparities among a large, multi-site cohort of PWH.

PI_NAMEs: CHANDER, GEETANJALI ;MCCAUL, MARY E (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;Acquired Immunodeficiency Syndrome;Address;Age;alcohol abstinence;alcohol abuse therapy;Alcohol consumption;alcohol exposure;alcohol intervention;alcohol relapse;alcohol related problem;alcohol research;alcohol risk;alcohol screening;alcohol use disorder;Alcohols;analytical method;antiretroviral therapy;Attention;Behavioral;Biological Markers;Biometry;brief intervention;Cardiovascular Diseases;Caring;Chronic Disease;Classification;Clinic;Clinical;clinical care;clinical infrastructure;clinical research site;co-infection;Cognition;cohort;Collaborations;Communities;comorbidity;computerized;Computers;contextual factors;Continuity of Patient Care;Data;Database Management Systems;Development;Disease remission;Disparity;drinking;Drug usage;Effectiveness;effectiveness/implementation design;effectiveness/implementation trial;Electronic Health Record;Epidemic;Epidemiology;epidemiology study;evidence base;Evidence based intervention;frailty;Frequencies;Goals;Health;high risk drinking;HIV;Hybrids;implementation research;implementation science;implementation strategy;implementation/effectiveness;Individual;Intervention;Intervention Studies;Intervention Trial;Knowledge;Liver diseases;Long-Term Effects;Longitudinal Studies;Malignant Neoplasms;Measures;Medical Records;Mental disorders;Methods;Neighborhoods;novel;Outcome;Patient Outcomes Assessments;Patient Self-Report;Persons;pharmacologic;pilot trial;Prevalence;preventive intervention;Process;programs;Quality of life;Recording of previous events;Relapse;relapse prevention;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resources;response;Risk;screening;Severity of illness;Site;social health determinants;Source;Structure;success;synergism;System;Testing;treatment as prevention;treatment strategy;United States Dept. of Health and Human Services;Universities;unsupervised learning;uptake;Viral hepatitis;Viremia

PROJECT_TITLE: Alcohol Research Consortium in HIV: Ending the HIV Epidemic through interventions and Epidemiology at the intersection of the alcohol and HIV care Continua


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Public Health Narrative This fundamental research will determine how “good” and “bad cholesterol” and associated proteins change their functionality in obesity. This research will also determine how these proteins interact with heparin, and how these interactions can contribute to the life-threatening complications of obesity such as cardiovascular and amyloid diseases.

PI_NAMEs: GURSKY, OLGA  (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acceleration;Address;Affect;Affinity;Affinity Chromatography;Aftercare;Alzheimer's Disease;American;Amyloid;Amyloid deposition;amyloid formation;Amyloidosis;Apolipoprotein A-I;Apolipoprotein A-II;Apolipoprotein E;Apolipoproteins;Apolipoproteins B;Atherosclerosis;bariatric surgery;Binding;Biochemical;biochemical tools;Biological Markers;Biological Models;biophysical tools;Biophysics;Books;Cardiovascular Diseases;Cardiovascular system;Cartoons;Cell Nucleus;Cells;Cessation of life;Cholesterol;Chronic;Complex;Complication;computerized tools;Computing Methodologies;COVID-19 mortality;crosslink;Data Set;Deposition;Deuterium;Diagnosis;diagnostic tool;Disease;Disease Management;disorder risk;extracellular;fundamental research;Goals;Heparin;Heparin Binding;Heparitin Sulfate;High Density Lipoproteins;Human;Hydrogen;In Vitro;in vivo;Inflammation;Kinetics;Life;Link;lipid metabolism;Lipids;Lipolysis;Lipoprotein (a);lipoprotein lipase;lipoprotein triglyceride;Lipoproteins;Low-Density Lipoproteins;Mass Spectrum Analysis;Measures;Metabolic;Metabolism;mimetics;Minor;Modeling;Molecular;Molecular Conformation;Morbid Obesity;nanoparticle;Non-Insulin-Dependent Diabetes Mellitus;novel;novel diagnostics;novel marker;obese patients;obese person;Obesity;obesity biomarkers;obesity treatment;Outcome;particle;Particle Size;Pathway interactions;Patients;Periodicals;Peripheral;Pilot Projects;Plasma;Population;premature;Process;Progress Reports;Property;protein misfolding;Proteins;Public Health;Publications;Receptor Cell;Research;Role;Serum amyloid A protein;severe COVID-19;stem;Structure;Surface;Testing;therapeutic target;tissue tropism;Triglycerides;Very low density lipoprotein;Virus Diseases;Work

PROJECT_TITLE: Apolipoprotein conformation in amyloid and cardiovascular diseases

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;HIV/AIDS;Prevention;Substance Misuse

PI_NAMEs: CHANDER, GEETANJALI  (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;adjudication;Advisory Committees;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol epidemiology;alcohol exposure;alcohol intervention;alcohol research;alcohol use disorder;Alcohols;Attention;Biometry;burden of illness;career development;Caring;Characteristics;Clinical;clinical care;Clinical Research;co-infection;cohort;Collaborations;Communication;Communities;comorbidity;contextual factors;Continuity of Patient Care;Data Collection;data repository;Development;Discipline;eHealth;Ensure;Epidemic;Epidemiology;epidemiology study;experience;Faculty;Foundations;Funding;Funding Agency;Goals;Health;health disparity;HIV;HIV/AIDS;implementation research;implementation science;Individual;Information Dissemination;Infrastructure;innovation;Interdisciplinary Study;International;Intervention;Intervention Studies;Knowledge;Lead;Link;Maintenance;meetings;Methodology;Methods;Monitor;National Institute on Alcohol Abuse and Alcoholism;Outcome;Patient Outcomes Assessments;Patients;Persons;Prevention Research;primary care clinic;primary care visit;Process;Productivity;programs;Psychology;Publications;Quality Control;relapse prevention;Research;Research Personnel;Research Priority;Research Project Grants;Resource Allocation;Resources;Schedule;Services;Site;social;social health determinants;Special needs;Structure;student mentoring;Students;synergism;System;Technology;treatment as prevention;treatment disparity;Treatment outcome;United States;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Alcohol Research Consortium in HIV:  Administrative Core


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: MISSOULA

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: The Center for Biomolecular Structure and Dynamics (CBSD), an NIH Center of Biomedical Research Excellence, supports research programs that use biophysical and structural biology methods to understand the underlying mechanisms of normal and pathological physiological processes. This proposal will fund the instrumentation-intensive research core facilities necessary to conduct this research and programs designed to sustain the center over the long term so that CBSD researchers can continue to lay the groundwork to discover new therapies for the treatment of human pathogens, diabetes, neurodegenerative diseases, and cancer.

PI_NAMEs: BOWLER, BRUCE E (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Acceleration;Applications Grants;Area;Award;base;Basic Science;Biological Process;Biomimetics;Biophysics;Budgets;career;cellular imaging;Centers of Research Excellence;Charge;cohort;college;Communities;Computational Biology;Core Facility;Counseling;Cryoelectron Microscopy;design;Development;Diabetes Mellitus;Disease;Docking;drug development;drug discovery;Educational workshop;Ensure;Equipment;Evolution;Extramural Activities;Faculty;Fees;Financial Support;Fluorescence;Fostering;Foundations;Funding;Future;Genes;Genetic Transcription;Goals;Grant;Grant Review;Growth;Health;Human;human pathogen;Humanities;Image;imaging capabilities;Imaging Techniques;in vivo;Incentives;Infrastructure;Institution;instrumentation;Investments;Laboratory Research;Ligands;macromolecule;Malignant Neoplasms;Mass Spectrum Analysis;Mathematical Biology;member;Mentors;metabolomics;Methods;Mission;Modernization;Molecular;Molecular Computations;molecular dynamics;Monitor;Montana;Neurodegenerative Disorders;novel therapeutics;Pathologic;Peer Review;Phase;Physiological Processes;Pilot Projects;Positioning Attribute;programs;protein expression;Proteomics;Publications;receptor;Research;research facility;Research Personnel;Research Support;Resolution;Resources;Role;Sampling;Science;Services;single molecule;small molecule;structural biology;Structural Chemistry;Structure;success;Translational Research;two-dimensional;United States National Institutes of Health;Universities;Water;Work;Writing

PROJECT_TITLE: Biomolecular Structure and Dynamics


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Chronic Pain;Emerging Infectious Diseases;Infectious Diseases;Influenza;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Pneumonia and Influenza

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The larynx is richly innervated with nerves and depends on release of neuro-transmitters and -peptides for relay of signals for sensory cells and following injury, likely via neuroimmune interactions. This objective of this application is to elucidate functional roles of afferent/efferent neural circuits and cells, develop a small animal injury model of postviral vagal neuropathy and test the hypothesis that ASCL1+ neuroendocrine and CHAT+ cells drive a neurosensory-immune circuit for laryngeal neuropathy and hypersensitivity. Results will provide insight into mechanisms promoting laryngeal health and targets for clinical treatment options for neurosensory disorders and viral-related mucosal inflammation.

PI_NAMEs: FOOTE, ALEXANDER G (contact)

PROJECT_TERMS: Acute;Address;Affect;afferent nerve;airway hyperresponsiveness;Animals;arm;ASCL1 gene;Attention;Cell Physiology;cell type;Cells;Chronic;Clinical Treatment;conditional knockout;Coughing;Data;Diagnostic;Disease;Dysplasia;effective therapy;Efferent Neurons;efficacy testing;Environment;Epithelium;Etiology;experimental study;Faculty;Functional disorder;Genetic;Goals;Health;Hypersensitivity;Image;Immune;Immune response;improved;Infection;Inflammation;Inflammatory;Influenza A virus;influenza infection;Injury;innovation;insight;Knockout Mice;Laryngeal Epithelium;Laryngeal Mucosa;Laryngismus;Larynx;Link;Lung;Maps;Mediating;Mentors;Modeling;Motor;mouse genetics;mouse model;Mucositis;Mucous Membrane;mutant;Nerve;neural;neural circuit;Neuroendocrine Cell;Neuroimmune;Neuroimmunomodulation;neuroinflammation;Neurons;Neuropathy;neuroregulation;Neurosecretory Systems;neurosensory;neurotransmitter release;novel;Organ;Outcome;Paralysed;Pathway interactions;Peptides;Physiology;Population;Postdoctoral Fellow;programs;repaired;Research;Research Personnel;Resolution;Respiratory Signs and Symptoms;Role;Science;Secretory Cell;sensor;Sensorimotor functions;Sensory;sensory neuropathy;Signal Transduction;Specialist;Testing;Therapeutic;therapeutic target;Tissues;transcriptome;transcriptomics;Transgenic Animals;Upper Respiratory Infections;Upper respiratory tract;Vagus nerve structure;Viral;Virus;Virus Diseases;vocal cord;Voice;Work

PROJECT_TITLE: Neuroimmune interactions for laryngeal sensorimotor neuropathy in postviral influenza infection


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Award;base;Biomedical Research;Budgets;career;Centers of Research Excellence;Charge;Collaborations;Communication;Communities;Core Facility;Counseling;Coupled;Data;Educational workshop;Ensure;Environment;Evaluation;Evolution;Feedback;Funding;Future;Goals;Grant;Grant Review;Growth;improved;Income;informal atmosphere;instrumentation;Leadership;meetings;member;Mentors;Mission;Molecular;Monitor;Montana;Occupational activity of managing finances;operation;outreach;peer;Phase;Pilot Projects;programs;Progress Reports;recruit;Regulation;Research;Research Personnel;Resources;Role;Science;Series;Services;Structural Biologist;Structure;success;synergism;United States National Institutes of Health;Universities;voucher;Water;Writing

PROJECT_TITLE: Administrative Core: Biomolecular Structure and Dynamics


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: LAU, BRYAN  (contact)

PROJECT_TERMS: Abstinence;Accounting;Address;Affect;Age;alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol relapse;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Area;barrier to care;Biological Markers;Biometry;Cardiovascular Diseases;Caring;Clinical;Cognition;cohort;Collaborations;Communities;comorbidity;comparison group;contextual factors;Continuity of Patient Care;Data;data management;Data Sources;design;Development;Disease remission;Effectiveness;Electronic Health Record;Epidemic;Epidemiologic Methods;Epidemiology;Event;evidence base;frailty;Goals;Grant;Heterogeneity;HIV;HIV Infections;implementation science;improved;Individual;innovation;insight;Intervention;Leadership;Learning;Liver diseases;Machine Learning;machine learning prediction;Malignant Neoplasms;Measurement;Measures;Medical Records;Methodology;Methods;Neighborhoods;novel;Outcome;Patient Outcomes Assessments;Patient Self-Report;Persons;Population;predictive modeling;Process;Property;Publications;Recording of previous events;Recovery;Relapse;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Science;Site;social determinants;social health determinants;Source;Statistical Methods;success;supervised learning;treatment as prevention;Treatment outcome;unsupervised learning;uptake

PROJECT_TITLE: Alcohol Research Consortium in HIV: Biostatistics and Method Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: OVERALL Narrative The Seattle Wellstone Center is focused on translational research into the 2 most common forms of muscular dystrophy: FSHD and DMD. Our groups are exploring mechanisms of disease progression with a focus on remaining barriers to therapeutic development, including developing enhanced gene therapies.

PI_NAMEs: CHAMBERLAIN, JEFFREY S (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: adenovirus mediated delivery;Advocacy;Animal Model;Animals;Biological;boys;career;Characteristics;Clinical;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;Data Analyses;Data Set;design;Development;Disease;Disease Progression;Dose;Dose Limiting;Duchenne muscular dystrophy;Dystrophin;Education;Education and Outreach;Educational Activities;effective therapy;Ensure;Epitopes;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Family;Fellowship;Foundations;Future;Gene Delivery;gene therapy;Goals;graduate student;Human;Human Characteristics;immunogenicity;improved;Infrastructure;intein;inter-institutional;Lead;Magnetic Resonance Imaging;Measurement;Measures;Mediating;meetings;Mentors;Methods;micro-dystrophin;Miniature Swine;Molecular;Monitor;mouse model;Muscular Dystrophies;Myocardium;next generation;novel therapeutics;Online Systems;outreach;Patient advocacy;Patients;Performance;porcine model;Postdoctoral Fellow;Pre-Clinical Model;preclinical study;predictive modeling;Production;Reagent;recruit;Research;Research Personnel;Research Training;Resource Sharing;Resources;Safety;Skeletal Muscle;Speed;success;symposium;Technology;Testing;Therapeutic;therapeutic candidate;Therapeutic Clinical Trial;therapeutic development;Toxic effect;Training;transgene delivery;Transgenic Organisms;Translational Research;translational study;Variant;vector;Visit;Work

PROJECT_TITLE: Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Center - Seattle


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Narrative The protozoan Toxoplasma gondii is an opportunistic parasite causing encephalitis and birth defects, and is the number two most lethal food-borne infection in the USA. In order to identify additional drug targets to increase the limited treatment options, the stress-related transcriptional program will be dissected for its role in resisting stress faced by parasites residing in the extracellular environment versus the role of stress in the initiation and/or maturation of bradyzoite cyst differentiation.

PI_NAMEs: GUBBELS, MARC-JAN  (contact);ZARRINGHALAM, KOUROSH

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Automobile Driving;Back;Binding Sites;biological adaptation to stress;Biology;cancer therapy;Carbon Dioxide;Cell Cycle;Cell Cycle Stage;cell type;Cells;Cellular Stress;Chronic;Cleavage Under Targets and Release Using Nuclease;Clinical;Cluster Analysis;combinatorial;Communities;comparative;computational pipelines;computerized tools;Congenital Abnormality;Cyst;Data;Data Analyses;Data Set;differentiation in vitro;DNA Binding;Drug Targeting;Early identification;Encephalitis;Environment;Event;experimental study;Exposure to;extracellular;Fibroblasts;foodborne infection;gene interaction;Genes;Genetic Transcription;Genotype;Human;Hypersensitivity;Immune;Immune response;Impairment;In Vitro;Individual;Infection;innovation;insight;Interferon Type II;knock-down;Knowledge;Life;Maps;Mediating;Modeling;Muscle Cells;Muscle Fibers;Neurons;new therapeutic target;novel;novel therapeutic intervention;obligate intracellular parasite;Opportunistic Infections;Organ Transplantation;Parasites;Pathway interactions;Pharmaceutical Preparations;Phase;Physiological;Population;Positioning Attribute;programs;promoter;reference genome;Research;Resistance;Resources;response;Role;single-cell RNA sequencing;Stress;stressor;System;Time;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomics;Validation;Work

PROJECT_TITLE: Defining the shared transcriptional network underlying Toxoplasma extracellular stress and stage transition

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(02)]


PI_NAMEs: SPRANG, STEPHEN R (contact)

PROJECT_TERMS: analytical method;analytical tool;Biochemistry;Biological Process;Biophysics;Cellular biology;Centers of Research Excellence;Charge;Client;Client satisfaction;Collaborations;Complex;Core Facility;Cryoelectron Microscopy;Crystallography;design;Ensure;Evaluation;Faculty;Fee-for-Service Plans;Funding;Funding Opportunities;Future;Genes;Goals;Grant;Institution;instrumentation;Laboratories;Ligand Binding;light scattering;Measurement;Methodology;Mission;Molecular Biology;Molecular Structure;Monitor;Montana;Outcome;Performance;Phase;Pilot Projects;Policies;Process;Productivity;Property;protein expression;protein purification;Proteins;Publications;Reporting;Research;research faculty;Research Personnel;Resources;Self-Examination;service programs;Services;small molecule;Standardization;Structural Biochemistry;structural biology;Structure;student training;Surface Plasmon Resonance;Surveys;Technical Expertise;Technology;Thermodynamics;tool;Training;Universities;Validation;X-Ray Crystallography

PROJECT_TITLE: Integrated Structural Biology Core


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: CRANE, HEIDI M. (contact)

PROJECT_TERMS: Address;Adherence;adjudication;Admission activity;age related;Age related comorbidities;aging population;Alcohol consumption;alcohol effect;alcohol intervention;alcohol misuse;alcohol research;alcohol use disorder;Alcohols;antiretroviral therapy;Anxiety;arm;Atrial Fibrillation;Biostatistical Methods;Caring;Censuses;cerebrovascular;Clinical;Clinical assessments;clinical care;Clinical Data;clinical infrastructure;cohort;Collaborations;Communities;comorbidity;Continuity of Patient Care;COVID-19;COVID-19 complications;COVID-19 pandemic;Data;Data Collection;Disease;disease transmission;disparity reduction;drinking;Drug usage;end stage liver disease;Epidemic;Epidemiology;epidemiology study;experience;flexibility;food insecurity;frailty;Gender;gender diverse;Geography;Health;health care delivery;health data;health related quality of life;Healthcare;Heart failure;High Prevalence;HIV;Homelessness;Hospitalization;Housing;Imprisonment;improved;Incidence;Individual;innovation;Intervention;Intubation;Joints;Knowledge;life span;Long-Term Effects;marginalized population;Mental Depression;Mental disorders;Mental Health;Modeling;Modernization;mortality;novel;Outcome;outcome disparities;pandemic disease;pandemic impact;Patient Outcomes Assessments;Patients;Pattern;Persons;Population Heterogeneity;Poverty;racial diversity;Reporting;Research;Research Priority;Resources;response;Risk;Role;Severities;Site;social;Social Distance;social health determinants;Social isolation;social stigma;Social support;socioeconomics;Standardization;Statistical Models;Street Address;Structural Models;success;Symptoms;System;telehealth;thrombotic complications;transgender women;United States National Institutes of Health;venous thromboembolism;Viral;Work

PROJECT_TITLE: Alcohol Research Consortium in HIV: Epidemiology Research Arm


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Heart Disease;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Pediatric cardiac arrest in the out-of-hospital setting is a tragic event that affects over 7000 children less than 18 years of age in the US annually. Many of these children are successfully resuscitated, but the majority later die in the hospital or are left with severe lifelong disabilities for many years secondary to the brain injury occurring during the cardiac arrest. This clinical trial proposes to first determine whether longer durations of cooling improve recovery better than shorter durations of cooling and secondly to determine the best duration of cooling, in comatose patients resuscitated from cardiac arrest.

PI_NAMEs: MEURER, WILLIAM JOSEPH;MOLER, FRANK W (contact);TOPJIAN, ALEXIS A.

PROGRAM_OFFICER_NAME: PEMBERTON, VICTORIA

PROJECT_TERMS: 18 year old;Accident and Emergency department;Adaptive Behaviors;Adult;Adverse event;Affect;age group;American Heart Association;Asphyxia Neonatorum;Brain;Brain Injuries;Cardiopulmonary Arrest;Categories;cerebral ischemic injury;Cerebrum;Cessation of life;Child;Childhood;Clinical;clinical investigation;clinical practice;Clinical Trials;Clinical Trials Network;Cohort Studies;Coma;Data;Data Reporting;Development;Devices;Dose;Emergency Care;Etiology;Evaluation;Event;experience;FDA approved;Fever;Goals;Guidelines;Heart Arrest;Hospitals;Hour;Hypoxic-Ischemic Brain Injury;improved;improved outcome;Infrastructure;innovation;International;Left;Life Expectancy;Lifelong disability;Long-Term Care;Long-Term Survivors;Measures;Methods;Modeling;mortality;Multicenter Studies;National Heart, Lung, and Blood Institute;National Institute of Neurological Disorders and Stroke;natural hypothermia;neonate;neurobehavioral;neurological recovery;neuroprotection;out-of-hospital cardiac arrest;Outcome;Parents;Patient Admission;Patient Selection;Patients;Pediatric Intensive Care Units;Performance;Population;pre-clinical;preference;prevent;Publications;Quality of life;Recommendation;Recovery;Reporting;Resources;response;Resuscitation;Safety;secondary endpoint;Secondary to;Selection Criteria;societal costs;Survival Analysis;Survivors;Temperature;Therapeutic;Time;treatment duration;treatment effect;trend;trial design;United States National Institutes of Health;Update

PROJECT_TITLE: 1/2 Pediatric Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: ROSS, J B ALEXANDER  (contact)

PROJECT_TERMS: Address;Alaska;Alberta province;analytical ultracentrifugation;Applications Grants;Award;base;Biochemical;Biochemistry;Biological Sciences;biological systems;biomacromolecule;Biophysics;Biotechnology;Canada;Cells;Centers of Research Excellence;Charge;Client;Client satisfaction;Collaborations;Communities;Complex;confocal imaging;Data;design;Disease;Doctor of Philosophy;Educational process of instructing;Educational workshop;Effectiveness;Electronics;Ensure;Environmental Health;Evaluation;experience;experimental study;Fee-for-Service Plans;Fees;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Spectroscopy;Fostering;Foundations;Funding;Geoscience;graduate student;Grant;Health;Image;imaging system;Individual;Industrialization;insight;Institution;instrumentation;interdisciplinary approach;Laboratory Research;Lasers;Lateral;lectures;Measures;Microscope;Microscopic;Microscopy;Mission;Molecular Biology;Monitor;Montana;multiphoton microscopy;Neurosciences;operation;Outcome;Pacific Northwest;Phase;Photons;Postdoctoral Fellow;Productivity;programs;Progress Reports;Reporting;Research;Research Personnel;Resolution;Resources;Scanning;Science;Scientist;service programs;Services;single molecule;small molecule;Specificity;Spectrum Analysis;Structure;Students;success;Surveys;System;Technology;Time;Tissues;tool;Training;Training and Education;training opportunity;translational medicine;Trust;ultra high resolution;United States National Institutes of Health;Universities;Visualization;Washington

PROJECT_TITLE: BioSpectroscopy Research Laboratory


ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Public Health Relevance/Narrative The goal of this technology development proposal, “Single molecule localization microscopy via angstrom-scale three-dimensional imaging of electron spin labels”, is to create a technology for localizing individual biomolecules with angstrom precision using spin labels. This technology would allow one to determine how biomolecules are arranged in single copies of complex biomolecular assemblies. The molecular machines that carry out biological processes such as transcription, translation, signaling, and locomotion are complex assemblies comprised of mul- tiple biomolecules. The ability to determine the structure of these assemblies at the single molecule level would signiﬁcantly accelerate eﬀorts to understand — and design interventions for — a broad spectrum of biological processes, disorders, and diseases.

PI_NAMEs: MAROHN, JOHN A (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Acceleration;Antibodies;Architecture;Biological;Biological Process;Biology;cantilever;Cells;cold temperature;Collection;Complex;cryogenics;Data;density;Detection;detector;Development Plans;Diameter;Disease;Electrons;experimental study;Explosion;Freezing;Frequencies;Frustration;Genetic Transcription;Goals;Image;improved;Individual;innovation;irradiation;Label;Location;Locomotion;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Magnetism;Maps;Mechanics;Microscope;Microscopy;microwave electromagnetic radiation;microwave imaging;Molecular Machines;Motion;nanometer;new technology;Noise;novel;Nucleic Acids;Optics;Organelles;Physiologic pulse;Positioning Attribute;protein complex;Proteins;Protocols documentation;public health relevance;reconstruction;Resolution;Role;Sampling;Scheme;Signal Transduction;simulation;single molecule;Source;Spin Labels;Structure;Surface;Technology;technology development;Temperature;theories;therapy design;Three-Dimensional Imaging;Time;Translations;ultra high resolution;Vacuum;Work

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Statement of Broader Impact Despite longstanding scholarship that calls for science instruction to center student interest, address socio scientific issues, and promote social justice, there continues to be a persistent and problematic relationship between race, class, health and environmental risks. EMPOWER (Enacting Materials to Promote OWnership, Engagement and Relevance) aims to prepare teachers to adapt and use curriculum materials so that students will be engaged, interested, and empowered to enact change in their urban, small urban, and rural communities. EMPOWER will transform the research and practice community by amplifying the voices of students in the process of curriculum design and enactment, and broaden our understanding of the relationships between teachers, curriculum materials, students, and the socio political contexts in which students live.

PI_NAMEs: KO, MONLIN MONICA  (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;Belief;cohort;Color;Communities;Community Practice;design;Development;Educational Curriculum;Educational process of instructing;Educational workshop;empowerment;Environmental Health;Environmental Risk Factor;Face;Goals;Health;Human;Instruction;interest;junior high school;Knowledge;Learning;learning strategy;Libraries;Mediating;Memory;minority student;Morphologic artifacts;Next Generation Science Standards;open source;Ownership;Politics;Process;programs;Race;recruit;Research;Research Activity;Research Personnel;Rural Community;Scholarship;school district;Science;Social Justice;student participation;Students;Surveys;teacher;Teacher Professional Development;theories;United States;Urban Community;Video Recording;Voice;Work

PROJECT_TITLE: EMPOWER: Enacting Materials to Promote OWnership, Engagement and Relevance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Prevention;Substance Misuse

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adoption;Age;alcohol abuse therapy;Alcohol consumption;alcohol misuse;alcohol research;Alcohols;antiretroviral therapy;Area;arm;Behavioral;Boston;brief intervention;Cardiovascular Diseases;Caring;Clinic;Clinical;clinical practice;Cognition;Cognitive Therapy;comorbidity;Computers;Consolidated Framework for Implementation Research;Continuity of Patient Care;Effectiveness;effectiveness outcome;effectiveness testing;Epidemic;Epidemiology;Evaluation;evidence base;Evidence based intervention;experience;flexibility;formative assessment;frailty;future implementation;High Prevalence;HIV;Hybrids;implementation evaluation;implementation facilitators;implementation outcomes;implementation research;implementation science;implementation strategy;implementation/effectiveness;improved;Infrastructure;Interruption;Intervention;intervention delivery;Investments;Knowledge;Liver diseases;Maintenance;Malignant Neoplasms;medication compliance;Methods;Modeling;National Institute on Alcohol Abuse and Alcoholism;Outcome;Patient Care;Patients;Persons;pharmacologic;Pharmacotherapy;Phase;post implementation;preference;primary outcome;Provider;Reach, Effectiveness, Adoption, Implementation, and Maintenance;reduced alcohol use;Research;Research Priority;Resources;Risk;Risk Behaviors;Sexual Transmission;Site;System;Telemedicine;Testing;therapy adherence;Time;Time Series Analysis;tool;Translations;transmission process;treatment as prevention;Treatment Efficacy;uptake;Viral;Viral hepatitis;Work

PROJECT_TITLE: Alcohol Research Consortium in HIV: Implementation Research Arm


ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative Aberrations in genes that help repair damaged DNA are seen in 20-25% of men with metastatic castration- resistant prostate cancer, the lethal form of prostate cancer. We have assembled a multidisciplinary team to increase our understanding of the role the spectrum of DNA repair aberrations play in early prostate cancer. Specifically, we will study men with high-risk localized and oligometastatic prostate cancer to evaluate the usefulness of testing for these aberrations, to develop new strategies to treat the potentially lethal form of the disease early, and to improve outcomes for patients and their relatives who carry inherited aberrations in DNA repair genes.

PI_NAMEs: OFFIT, KENNETH  (contact);POMERANTZ, MARK M.

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: Address;advanced disease;adverse outcome;androgen independent prostate cancer;cancer diagnosis;Cancer Etiology;Cessation of life;Clinical;Clinical Investigator;clinically significant;Data;Diagnosis;Disease;disease natural history;DNA Repair;DNA Repair Gene;DNA Repair Pathway;Early Intervention;Epidemiologist;Ethnic Origin;Ethnic Population;Frequencies;gene repair;Genes;Genetic Variation;Germ Lines;Germ-Line Mutation;Goals;high risk;improved;improved outcome;Individual;Inherited;insertion/deletion mutation;Institution;Intervention;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;men;Molecular Abnormality;multidisciplinary;mutational status;Outcome;Pathogenicity;Pathologist;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Play;precision medicine;programs;prostate cancer risk;Protein Truncation;Research Personnel;Role;Scientist;screening;Screening for Prostate Cancer;Series;Somatic Mutation;systemic intervention;Testing;Therapeutic;Time;treatment strategy;tumor;United States;Variant;Vision

PROJECT_TITLE: The Impact of DNA Damage Repair Abnormalities in Prostate Cancer


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: NARRATIVE. The Catalyzing Cancer Research among Urban Underrepresented Minority Youths and Teachers (CATALYST) program expands upon seven years of a successful intervention pilot to excite middle school (MS) students from disadvantaged West Baltimore communities about cancer-related STEM subjects and careers. CATALYST will incorporate cancer research experiences for teachers that are used to develop MS curriculum and community outreach components. Integral to the success of this program is a holistic approach to address scholar, family and community needs that are essential for academic success. CATALYST scholars are part of a cancer-focused STEM education pipeline that will produce the next generation of researchers and healthcare professionals. This diverse workforce will stimulate innovation, enhance productivity and foster consideration of disparities issues in the fight against cancer.

PI_NAMEs: ADEBAMOWO, CLEMENT ADEBAYO (contact);ADEBAMOWO, SALLY NNEOMA;HASSEL, BRET A

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;anti-cancer research;Area;Back;Baltimore;cancer education;cancer health disparity;career;Career Exploration;Caregivers;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;curriculum development;Data;Development;Development Plans;Disadvantaged;disadvantaged student;Disparity;Diverse Workforce;Education;education pathway;Educational Activities;Educational Curriculum;Educational Intervention;Ensure;experience;Faculty;Family;fighting;Fostering;Foundations;Funding;Goals;Health Care Research;Health Professional;Health Sciences;Healthcare;high school;holistic approach;improved;Incidence;Individual;Infrastructure;innovation;Institution;interest;Journals;junior high school;Learning;Longterm Follow-up;Malignant Neoplasms;Maryland;Medical;Mentors;Middle School Faculty;Middle School Student;minority children;minority communities;next generation;novel;Outcome;outcome disparities;outreach;Participant;peer;Peer Review;Population;Positioning Attribute;Production;Productivity;program dissemination;programs;Publishing;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Resources;Schools;Science;science education;Science, Technology, Engineering and Mathematics Education;Secondary Schools;social determinants;social health determinants;social learning;Social Network;Structure;success;successful intervention;System;teacher;Teacher Professional Development;Trust;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;urban underrepresented;Vision;Visualization;Washington

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Address;Area;base;Biochemistry;Biophysics;Centers of Research Excellence;Charge;cluster computing;Collaborations;Communities;comparative;Computer Models;Computer software;computerized tools;computing resources;Consultations;Contract Services;Core Facility;cost effective;Data;Data Set;deep learning algorithm;design;Docking;Drug Design;Educational workshop;Ensure;Environment;Feedback;Fluorescence Spectroscopy;Goals;in silico;Individual;Infrastructure;insight;Investigation;Laboratories;Libraries;Ligands;Methods;Mission;Modeling;Molecular Computations;molecular dynamics;molecular mechanics;Montana;Nature;operation;Phase;Positioning Attribute;Process;programs;Proteins;Quantum Mechanics;receptor;Research;Research Personnel;Resources;Services;Structure;synergism;System;Techniques;Testing;tool;Training;Universities;user friendly software;X-Ray Crystallography

PROJECT_TITLE: Molecular Computation Core Facility


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Liver Cancer;Liver Disease;Natural Products;Nutrition;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Prevention of hepatocellular carcinoma (HCC) in cirrhosis is an urgent unmet medical need given the limited efficacy of existing therapies and resulting poor HCC mortality. We will test epigallocatechin gallate (EGCG), a green tea catechin, as a biomarker-guided dietary-supplement-based HCC chemoprevention in a phase II placebo-controlled clinical trial for its safety and efficacy in patients with cirrhosis. We will also explore clinical and molecular correlates with the response to inform design of subsequent phase III trial toward clinical translation of the therapy.

PI_NAMEs: HOSHIDA, YUJIN  (contact);SINGAL, AMIT

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Acoustics;Adverse event;Biological Markers;Cause of Death;cell type;Chemoprevention;Chemopreventive Agent;Cirrhosis;Clinical;Clinical Chemoprevention;clinical translation;Clinical Trials;clinically relevant;Conduct Clinical Trials;Consent;Controlled Clinical Trials;design;Development;dietary supplements;Double-Blind Method;elastography;Epigallocatechin Gallate;experimental study;follow-up;Future;Goals;Green tea;Hepatic;high risk;Histologic;Immunohistochemistry;improved;Incidence;indexing;Individual;insight;Liver;liver biopsy;liver stiffness;Lung;Malignant Neoplasms;Measurement;Measures;Mediating;Medical;Molecular;Molecular Target;Monitor;mortality;Myofibroblast;novel;Oral Administration;Participant;patient prognosis;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;permissiveness;Phase;phase I trial;Phase III Clinical Trials;phase III trial;Placebo Control;Placebos;Plasma;prevent;Prevention;prevention clinical trial;Primary carcinoma of the liver cells;primary endpoint;prognostic;Quality of life;Randomized;Research Design;response;Risk;Rodent Model;Safety;Sample Size;Sampling;secondary endpoint;senescence;Serum;Slice;Stromal Cells;Surrogate Endpoint;Testing;Therapeutic;Time;Tissues;translational approach;translational therapeutics;tumor

PROJECT_TITLE: Epigallocatechin gallate for prevention of lethal cirrhosis complications

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative This Training Program will serve the public health by developing MD- and PhD-trained independent investigators capable of conducting patient-oriented research to improve the quality of life and quality of care of the ever-increasing number and proportion of older Americans. Trainees will gain unique expertise in Behavioral Geriatrics, harnessing both biomedical and social/behavioral scientific approaches to study pressing problems of aging (e.g., pain, cognitive impairment, polypharmacy, caregiving, end-of-life medical decision making, bereavement).

PI_NAMEs: CZAJA, SARA J;REID, MANNEY CARRINGTON (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TITLE: The Weill Cornell Medicine Research Training Program in Behavioral Geriatrics


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Recovery Support Services;Substance Misuse

PI_NAMEs: HUTTON, HEIDI  (contact)

PROJECT_TERMS: Abstinence;Adherence;Adoption;Aftercare;AIDS prevention;alcohol abuse therapy;Alcohol consumption;alcohol relapse;alcohol research;alcohol risk;alcohol use disorder;Alcohols;Anxiety;arm;Behavioral Model;Caring;Clinic;Clinical;Clinical Services;comorbidity;Computer software;computerized;Computers;Continuity of Patient Care;Diagnosis;Dimensions;Disease remission;Disparity;drinking;Effectiveness;Effectiveness of Interventions;efficacy/implementation trial;Epidemic;Epidemiology;evidence base;experience;Feedback;Frequencies;Future;General Population;Health;Heavy Drinking;high risk;HIV;Hybrids;implementation framework;implementation outcomes;improved;Intervention;Interview;Literature;Maintenance;Mental Depression;Methods;Moods;Outcome;Outcome Measure;Participant;Patients;Pattern;personalized medicine;Persons;Phase;pilot test;Population;preventive intervention;Process;programs;Provider;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Relapse;relapse prevention;relapse risk;Risk;skills;social determinants;social disparities;substance use;success;synergism;Testing;therapy development;Time;Training;treatment as usual;treatment services;United States National Institutes of Health;uptake

PROJECT_TITLE: Alcohol Research Consortium in HIV: Relapse Prevention Arm


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_DEPT: OTHER CLINICAL SCIENCES

PHR: PROJECT NARRATIVE The mission and vision of the University of California, San Francisco's Clinical and Translational Science Institute (CTSI) is to accelerate research to improve health by creating and fostering a transdisciplinary clinical and translational science environment in collaboration with, and embracing the diverse group of scientific and community stakeholders at its center. Integrating core themes of the CTSA network, CTSI will continue to develop, demonstrate, and disseminate innovative research methods and technologies, with a strong and continuing commitment to train and sustain the next generation of clinical and translational scientists, diverse in their disciplines and demographics, and both well-prepared and positioned to lead in this transformative time characterized by the convergence of patient-centered care, digital health, and unprecedented computational power. Project Narrative Page 217

PI_NAMEs: COLLARD, HAROLD R;JACOBY, VANESSA  (contact);NGUYEN, TUNG T.

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Award;Beverages;Calendar;California;Childhood;Clinical;clinical care;Clinical Competence;Clinical Data;clinical development;Clinical effectiveness;Clinical Informatics;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;data interoperability;Data Science;demographics;Development;digital health;Discipline;early-career faculty;Effectiveness;Ensure;Environment;Equity;ethnic minority;extend lifespan;Fostering;Funding;Funding Opportunities;Future;gender minority;Goals;Grant;Health;health care delivery;Health system;Healthcare;Heterogeneity;Home;improved;Incentives;Individual;Informatics;Information Technology;Infrastructure;innovation;insight;Institution;interest;Lead;Learning;life span;Maintenance;Methods;minority trainee;Mission;National Institute of General Medical Sciences;next generation;operation;patient oriented;Patient-Centered Care;Patients;Policies;Policy Maker;Population;Positioning Attribute;Process;programs;racial minority;Research;Research Methodology;Research Personnel;research to practice;Resource Development;Resources;Rural Health;Rural Population;San Francisco;Science;Scientific Advances and Accomplishments;Secure;skills;soda tax;Special Population;Special Populations Research;success;synergism;System;Technology;Time;tool;Training;Training Programs;Translating;Translational Research;translational scientist;Underrepresented Minority;Universities;Vision;Workforce Development


PI_NAMEs: RYTER, KENDAL  (contact)

PROJECT_TERMS: Biological;Biomedical Research;biophysical analysis;Biophysics;Centers of Research Excellence;Client;Collaborations;Communities;Computer software;Consultations;Core Facility;Data;design;Ensure;Environment;Equipment;Evaluation;Fee-for-Service Plans;Fees and Charges;Fostering;Funding;Future;Goals;Human Resources;improved;Individual;innovation;Institution;instrumentation;Laboratories;Licensing;MALDI-TOF Mass Spectrometry;Mass Fragmentography;Mass Spectrum Analysis;Medical;metabolomics;mid-career faculty;Mission;Modernization;Montana;novel strategies;operation;outreach program;Peptide Mapping;Phase;Preparation;Property;Protein Analysis;Protein Dynamics;Proteins;Proteomics;Research;Research Personnel;Sampling;Schedule;Services;small molecule;Structure;Training;translational medicine;Universities;Work

PROJECT_TITLE: Mass Spectrometry Core Facility


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Primary Health Care;Social Determinants of Health

PHR: PROJECT NARRATIVE The use of Community Health Workers has been found to be an effective strategy in reducing hypertension disparities, but there are barriers to their utilization in primary healthcare settings. Implementation science theories, frameworks, and methods may improve our understanding of how best to overcome these obstacles.

PI_NAMEs: IBE, CHIDINMA ADANNA (contact)

PROGRAM_OFFICER_NAME: PLEVOCK HAASE, KAREN MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Behavioral;blood pressure control;bone;Cardiovascular system;Care given by nurses;care outcomes;career;career development;Caring;Case Manager;Clinic;Clinical;Cluster randomized trial;collaborative care;Communities;community clinic;Community Health Aides;compare effectiveness;Complement;Consolidated Framework for Implementation Research;Data;design;Development;Development Plans;Diffusion;Disparity;disparity reduction;Effectiveness;ethnic disparity;experience;Exposure to;feasibility testing;Federally Qualified Health Center;Fostering;Foundations;Frontline worker;Funding;Future;Goals;health care service organization;health care settings;Health Personnel;Healthcare;Healthcare Systems;Hospitals;human centered design;Hypertension;hypertension control;ideation;implementation determinants;implementation research;implementation science;improved;Inequity;innovation;Institution;instrument;Internal Medicine;Intervention;Interview;Investigation;K-Series Research Career Programs;Life Style;Link;Managed Care;Measures;Medical;Medical Care Team;medical schools;meetings;member;Mentors;Methods;Modeling;multidisciplinary;National Heart, Lung, and Blood Institute;Organizational Change;Outcome;Patient Self-Report;Patient-Focused Outcomes;Patients;Perception;Positioning Attribute;pragmatic randomized trial;Prevalence;primary care provider;Primary Health Care;Process;professor;Program Development;Psychometrics;psychosocial;Public Health;racial disparity;Randomized;Research;Research Activity;Research Personnel;Role;routine care;safety net;Scientist;Self Management;Shapes;Site;skill acquisition;skills;social;socioeconomics;standard of care;structural determinants;Structure;Testing;Theoretical Domains framework;theories;Training;Training Activity;Translations;Universities;uptake;vulnerable community;Vulnerable Populations;Work;working group

PROJECT_TITLE: Community Health Worker Integration into Healthcare Teams: Advancing a Theory-driven Implementation Science Model


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Eye Disease and Disorders of Vision;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Photophobia, or abnormal sensitivity to light, is a common symptom of a migraine, which is a disabling neurologic disorder. This project aims to better understand how signals from the eye that code the brightness of light interact with pain signals from the head using a mouse model of migraine. The long-term goal is to develop new, targeted therapeutic options for migraine and photophobia.

PI_NAMEs: KAISER, ERIC ALAN (contact)

PROGRAM_OFFICER_NAME: SYPEK, ELIZABETH IRENE

PROJECT_TERMS: Ablation;Affect;Behavior;Behavioral Model;Biometry;Calcitonin Gene-Related Peptide;career;career development;Chemosensitization;Clinical;Code;common symptom;Cone;Cornea;Development Plans;Disabling;disabling symptom;Disease;Doctor of Philosophy;Dura Mater;Educational process of instructing;Ethics;experience;Eye;Faculty;FOS gene;Functional disorder;Future;Generations;Goals;Grant;grasp;Head;Headache;Household;Human;Immunohistochemistry;improved outcome;Individual;inhibitor;instructor;irritation;K-Series Research Career Programs;Knock-in Mouse;Knowledge;Lateral Geniculate Body;Learning;Light;Mediating;Medicine;melanopsin;Mentors;Methods;Migraine;mouse genetics;mouse model;Mus;Nature;Nervous System Disorder;neural;neural circuit;neural network;Neural Pathways;Neurogenic Inflammation;Neurology;neuromechanism;Neuronal Plasticity;Neurons;Neuropeptides;Neurosciences;new therapeutic target;Nociception;optogenetics;Pain;pain signal;Pathogenesis;Pathologic;Pathway interactions;Pediatric Hospitals;Pennsylvania;Perception;Peripheral;Persons;Philadelphia;Photophobia;Photoreceptors;Photosensitivity;Physicians;Physiologic pulse;Play;Population;Population Scientist Supplement (R25);pre-clinical;programs;Protocols documentation;Reporting;Research;Resources;response;Retina;Retinal Ganglion Cells;Rodent;Rodent Model;Role;Scientist;sensory system;Signal Transduction;Site;skills;Spreading Cortical Depression;Stimulus;Structure;System;targeted treatment;Technical Expertise;Techniques;Testing;Thalamic structure;tool;Training;Traumatic Brain Injury;treatment trial;trial design;Trigeminal System;United States National Institutes of Health;Universities;Vasodilation;Visual;Visual Discomfort;Visual Pathways;Visual Perception;visual processing;Visual System;Work;Writing

PROJECT_TITLE: Neural Pathways of Light Aversion in a Rodent Model of Migraine


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Infectious Diseases;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE I propose that HPV DNA integration into the human genome promotes is a crucial early event in cervical dysplasia and cancer that promotes the emergence of expanded clones of altered cells. The proposed project will directly analyze early steps in proliferation and clonal evolution of keratinocytes harboring HPV DNA integrations in both patient samples and cell cultures. It will formally test the hypothesis that HPV DNA insertion acts by stabilizing expression of viral oncogenes and by activating human cancer genes that flank sites of viral DNA integration in the human genome.

PI_NAMEs: VAN ARSDALE, ANNE  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Award;Bar Codes;Biological Assay;Cancer Etiology;Carcinoma;career;Cell Culture Techniques;Cell Cycle;Cells;Cervical;Cervical dysplasia;Cervical Intraepithelial Neoplasia;Cervix Carcinoma;Cervix Neoplasms;Circular DNA;Clinical;Clonal Evolution;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Color;Contact Inhibition;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Custom;Development;Disease;DNA;DNA Integration;DNA sequencing;DNA Structure;ds-DNA;Dysplasia;Endowment;Engineering;Episome;Epithelium;Event;Fluorescent in Situ Hybridization;Funding;Genes;genetic testing;Genome;Genomic DNA;Genomic Instability;genomic locus;Goals;Growth;Guide RNA;Histologic;HPV screening;HPV-High Risk;Human;human DNA;Human Genome;Human papilloma virus 45;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Human papillomavirus 18;Individual;Infection;insight;integration site;interest;Interphase;Invaded;K-Series Research Career Programs;keratinocyte;Knowledge;Label;Laboratories;laboratory experience;Laboratory Research;Lentivirus;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Maps;Mentors;Methodology;Methods;migration;Modeling;Molecular;Molecular Structure;next generation sequencing;Normal Cell;novel;Nucleotides;Oncogenes;Oncogenic;Outcome;Pathogenicity;Patients;Phase;Phenotype;Plasmids;Population;Positioning Attribute;premalignant;programs;Proliferating;promoter;Property;PVT1 gene;Recombinants;Recurrence;Research;Research Design;Research Personnel;Resolution;Role;Sampling;Science;Scientist;Site;skills;spatiotemporal;System;Technology;Testing;tool;Training;Transcriptional Activation;transcriptomics;Transfection;tumor;Tumor Promotion;tumorigenesis;tumorigenic;Viral;viral DNA;Viral Genome;Viral Oncogene;Virus Integration;Visualization;Woman

PROJECT_TITLE: Pathogenic role of human papillomavirus (HPV) DNA Integration and clonal expansion in cervical tumorigenesis

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Muscular Dystrophy;Rare Diseases

PI_NAMEs: CHAMBERLAIN, JEFFREY S (contact)

PROJECT_TERMS: Advertising;Advisory Committees;Advocacy;Animals;Area;Communities;Critiques;Data;data sharing;Doctor of Medicine;Doctor of Philosophy;Education and Outreach;Educational Activities;Ensure;Event;Funding;Goals;Individual;Institution;Institutional Review Boards;lectures;Legal patent;Link;meetings;member;Mentors;Methods;Mission;Muscular Dystrophies;operation;outreach;outreach program;patient advocacy group;Patients;Progress Reports;Publications;Reagent;Research;Research Personnel;Resource Sharing;Resources;Schools;Science;Series;symposium;Training;Training Activity;Travel;vector;Visit;web site;Work

PROJECT_TITLE: ADMIN CORE


NIH_SPENDING_CATS: Clinical Research;Lung;Physical Activity;Pulmonary Hypertension;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Right ventricular (RV) failure is the predominant cause of death in patients with pulmonary arterial hypertension, but no RV-specific treatments exist because the underlying mechanisms are poorly understood. We recently discovered marked accumulation of lipid (steatosis) in the human PAH RV. We propose to study the relationship between RV steatosis and RV function, exercise capacity, and outcomes in humans with PAH and to identify potential drivers of lipid accumulation.

PI_NAMEs: BRITTAIN, EVAN L (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Activities of Daily Living;acylcarnitine;Address;Animal Model;Apoptosis;Autopsy;Biological Assay;biomarker validation;BMPR2 gene;Body mass index;candidate identification;cardiac magnetic resonance imaging;Cardiopulmonary;Cause of Death;Ceramides;Circulation;Clinical;clinical phenotype;Clinical Research;clinically relevant;Coronary sinus structure;Data;Defect;Event;evidence base;Exercise;exercise capacity;Exercise Test;experience;Fatigue;fatty acid oxidation;Fatty Acids;Foundations;Functional disorder;Future;Glucuronates;hemodynamics;Heritability;High Prevalence;Human;Impairment;improved outcome;in vivo;insulin mediators;Insulin Resistance;Intervention;Knowledge;Link;lipid metabolism;lipidomics;Lipids;long chain fatty acid;Magnetic Resonance Spectroscopy;Measurement;Measures;Mediator;Medical;Metabolic;metabolomics;Metformin;Mitochondria;mouse model;Muscle;Muscle Cells;mutant;Natural History;Nonesterified Fatty Acids;novel;Outcome;Participant;Pathway interactions;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Pilot Projects;Plasma;primary pulmonary hypertension;prognostic;Proteins;Protons;Publishing;pulmonary arterial hypertension;Reporting;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Rodent Model;Sampling;Scleroderma;Skeletal Muscle;Specificity;Specimen;Subgroup;Testing;Therapeutic Intervention;tibialis anterior muscle;Transgenic Organisms;Vasodilator Agents;Ventricular;Walking;Work

PROJECT_TITLE: Clinical and Mechanistic Understanding of Right Ventricular Steatosis in Pulmonary Arterial Hypertension

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: BOWLER, BRUCE E (contact)

PROJECT_TERMS: Advisory Committees;Applications Grants;Area;Award;career;Centers of Research Excellence;Charge;Collaborations;Complex;Core Facility;design;Development;Educational workshop;Effectiveness;effectiveness evaluation;Elements;Faculty;Fostering;Funding;Goals;Grant;Growth;improved;Income;Institution;Journals;Mentors;Methods;Mission;Outcome;Paper;Peer Review;Phase;Pilot Projects;Productivity;programs;Publishing;Research;research facility;Research Personnel;Research Project Grants;Research Support;Secure;Strategic Planning;Structure;success;synergism;Techniques;Technology;technology development;trend;Water;Writing

PROJECT_TITLE: Pilot Projects


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Eating Disorders;Mental Health;Nutrition;Obesity;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Overweight and obesity remain significant public health concerns in the United States, and are difficult to treat; A strong overeating drive may contribute to weight gain and the common challenge of maintaining weight loss. The proposed K23 project refines the development of a healthy eating intervention, and conducts preliminary testing of this mechanism-focused mindfulness-based intervention to reduce overeating drive among adults with overweight. This research will advance our knowledge of specific mechanisms that can reduce overeating drive, and will have the potential to impact long-term metabolic health.

PI_NAMEs: RADIN, RACHEL MILLER (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;active control;Address;Adult;adult obesity;Area;Awareness;behavior change;Behavioral;Binge Eating;Body Weight decreased;career;career development;Clinical;Collaborations;Communities;Consultations;craving;Data;design;Development;diaries;digital;Drops;Eating;Eating Behavior;Educational Status;effective therapy;emotional eating;Enrollment;Evaluation;evidence base;Failure;Fellowship;Focus Groups;Goals;Health;Healthy Eating;high risk;high risk population;Hunger;Hyperphagia;improved;Individual;infancy;Insulin Resistance;Integrative Medicine;Integrative Therapy;Intervention;intervention refinement;K-Series Research Career Programs;Knowledge;Lead;Light;Maintenance;Measures;Meditation;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metabolic dysfunction;Metabolic syndrome;mindfulness;mindfulness intervention;Mindfulness Training;Motivation;motivational enhancement therapy;motivational intervention;National Center for Complementary and Integrative Health;novel;Obesity;Overweight;Participant;patient oriented research;Pattern;Phase;Pilot Projects;pilot test;Postdoctoral Fellow;programs;psychologic;Psychologist;Public Health;Qualitative Research;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Sampling;Science;Self Efficacy;symptom management;symptom science;Testing;therapy design;therapy development;Touch sensation;Training;trait;treatment effect;United States;Weight;Weight Gain;weight loss intervention;weight loss program;Work

PROJECT_TITLE: Development of an integrative intervention to decrease overeating drive and improve weight loss maintenancee


PI_NAMEs: REGNIER, MICHAEL  (contact)

PROJECT_TERMS: Address;advocacy organizations;Area;Award;Awareness;Basic Science;Biochemistry;Biology;Biomedical Engineering;Biomedical Research;Cardiovascular system;career;career development;Cellular biology;Childhood;Clinic;Clinical;Clinical Medicine;Clinical Research;Collaborations;Communication;Communities;cost;Coupled;Dedications;Discipline;Education;Education and Outreach;Educational process of instructing;Educational workshop;Environment;Ethics;Event;experience;Faculty;Family;Fellowship;Fostering;Funding;Goals;graduate student;Grant;Hand;Individual;insight;Institution;Intervention;Interventional radiology;Joints;Kansas;Knowledge;Lead;Medical;Medical center;Medicine;meetings;member;Mentors;Mentorship;Molecular Biology;Muscle;muscle physiology;Muscular Dystrophies;Musculoskeletal Diseases;Myopathy;Neurology;neuromuscular;Nevada;next generation;outreach;Pacific Northwest;Patient advocacy;patient advocacy group;Patients;Pediatric Hospitals;peer;Postdoctoral Fellow;Private Sector;Program Development;programs;Recording of previous events;recruit;Regenerative Medicine;Research;research and development;Research Personnel;Research Training;Resources;Role;Running;Scientist;Series;skills;Societies;stem cells;STEM program;Students;symposium;Talents;teacher;Training;training opportunity;Training Programs;Training Support;translational health science;Translational Research;undergraduate research;undergraduate student;United States National Institutes of Health;Universities;Update;Washington;Work;Writing

PROJECT_TITLE: Training Core


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Muscular Dystrophy;Rare Diseases

PI_NAMEs: CHAMBERLAIN, JOEL R (contact)

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Animals;Antibodies;Basic Science;Biotechnology;Canis familiaris;Capsid;Cardiac Myocytes;Cell Line;Cells;Centrifugation;Charge;Clinical Research;Collaborations;Complementary DNA;Consumption;cost;Cytokeratin-8 Staining Method;Cytomegalovirus;design;Doctor of Philosophy;Dystrophin;Family suidae;Funding;Gene Delivery;gene therapy;Gene Transfer;Genes;Hand;High Pressure Liquid Chromatography;Human Resources;Immune Sera;improved;induced pluripotent stem cell;interest;Laboratories;Learning;Lentivirus Vector;Medical;member;Methods;mouse model;Muscle;Muscular Dystrophies;Myoblasts;Myopathy;Plasmid Cloning Vector;Plasmids;Play;Preparation;prevent;Procedures;Production;Protein Isoforms;Protocols documentation;Quality Control;Reagent;Recombinants;Research;Research Personnel;research study;Resource Sharing;Resources;Retroviral Vector;RNAi vector;Role;Roller Bottle;Serotyping;Services;stem cells;Techniques;Technology;Time;Training;Translational Research;Universities;Utrophin;vector;Vertebral column;Viral;Viral Vector;Visit;Washington;web site;Work

PROJECT_TITLE: Shared Resources Core-Viral Vector Core


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orthopoxviruses;Rare Diseases;Vaccine Related

ORG_CITY: TEMPE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: The World Health Organization has identified monkeypox virus as the most important orthopoxvirus infection in humans after eradication of smallpox. Zoonotic monkeypox virus disease in Africa appears to be occurring more frequently in recent years, perhaps due to the cessation of smallpox vaccination. The work described in this proposal will aid in identifying treatments for monkeypox virus infections and in identifying safe vaccination regimens for preventing spread of monkeypox virus.

PI_NAMEs: JACOBS, BERTRAM L. (contact)

PROGRAM_OFFICER_NAME: KNISELY, JANE M

PROJECT_TERMS: Africa;Animal Experiments;Animal Model;Animals;Attenuated;Binding;canine model;Caspase;Cell Death;Cells;Cessation of life;Data;Disease Outbreaks;E3L gene;Exposure to;Failure;Funding;Genetic Recombination;Goals;Homologous Gene;Human;human pathogen;Immune Evasion;In Vitro;in vivo;Incubated;Infection;inhibitor;Interferons;Lead;loss of function mutation;Molecular;Monkeypox virus;mortality;Mus;mutant;N-terminal;Nucleic Acid Binding;Orthopoxvirus;pathogen;Pathogenesis;Pathogenicity;Pattern;Pattern recognition receptor;Persons;Phosphorylation;Phosphotransferases;Poxviridae;Prairie Dog;prevent;Proteins;prototype;Regimen;repaired;Research;Resistance;RIPK3 gene;Smallpox;smallpox eradication;Vaccination;vaccine development;Vaccinia virus;Viral Pathogenesis;Virulence;Virus;Virus Diseases;Work;World Health Organization;Zoonoses

PROJECT_TITLE: Monkeypox virus, Interferon, and Necroptosis

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


NIH_SPENDING_CATS: Burden of Illness;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

PHR: NARRATIVE Clinical outcomes among men diagnosed with localized prostate cancer are highly variable, even within the subset of patients whose disease has high-risk clinical features. This project proposes to comprehensively characterize the role of genetic aberrations in genes in the DNA repair pathway and the development of lethal prostate cancer in two at-risk populations: i) men diagnosed with high-risk, localized prostate cancer, and ii) African American men. Identification of genetic variants associated with lethal disease in these populations would profoundly influence prostate cancer screening and treatment strategies.

PI_NAMEs: OFFIT, KENNETH  (contact)

PROJECT_TERMS: Accounting;Address;Affect;African American;African American population;African ancestry;American;androgen independent prostate cancer;attributable risk;Biological;Biological Markers;Blood specimen;BRCA2 gene;cancer health disparity;Cancer Patient;Cessation of life;CHEK2 gene;chemotherapy;Clinical;clinical risk;cohort;Dana-Farber Cancer Institute;Data;Data Set;deep sequencing;Development;Diagnosis;Disease;disorder risk;DNA;DNA analysis;DNA Repair;DNA Repair Pathway;Epidemiology;European;European ancestry;Event;experimental study;Follow-Up Studies;Frequencies;gene repair;Genes;Genetic;Genetic Screening;genetic variant;Genome;genomic locus;Germ Lines;Germ-Line Mutation;Health;Health Professional;high risk;high risk men;high risk population;homologous recombination deficiency;Hospitals;Inherited;insertion/deletion mutation;International;Localized Disease;Longterm Follow-up;Malignant neoplasm of prostate;Memorial Sloan-Kettering Cancer Center;men;mortality;multi-ethnic;Mutation;mutational status;Natural History;Neoplasm Metastasis;new therapeutic target;novel;Operative Surgical Procedures;Outcome;PARP inhibition;Pathogenicity;Pathway interactions;Patient Care;patient stratification;patient subsets;Patients;Physicians;Platinum;Population;population based;Population Study;Populations at Risk;precision medicine;Prevalence;prognostic;prospective;Prospective cohort;Prostatic Neoplasms;Protein Truncation;PTEN gene;Public Health Schools;racial disparity;Radiation;Radical Prostatectomy;Reproducibility;Retrospective cohort;Risk;Role;Sampling;Screening for Prostate Cancer;Screening procedure;Somatic Mutation;Specimen;targeted treatment;Therapeutic Intervention;therapeutic target;Time;TMPRSS2 gene;TP53 gene;Treatment Protocols;treatment strategy;tumor;Variant;Vision

PROJECT_TITLE: The Clinical and Epidemiological Characterization of Pathogenic DNA Damage Repair Pathway Variation in Prostate Cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer

ORG_CITY: BINGHAMTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STATE UNIVERSITY OF NY,BINGHAMTON

PHR: PROJECT NARRATIVE The accurate assessment of a malignant solitary pulmonary nodule with medical imaging modalities normally takes months or even years of periodical surveillance, which increases the burden of healthcare costs and might increase the risk of metastasis. To make a definitive diagnosis with a five-day turnaround time, an assay for non-invasive, repeatable liquid biopsy will be developed to interrogate the genetic information in the lesion- derived extracellular vesicles (EV). Accordingly, a ready-to-use and disposable device for isolation of adequate EVs from plasma and a gene mutation panel for next-generation sequencing will be developed, validated, and translated to clinical use for molecular diagnostics in the near future.

PI_NAMEs: WAN, YUAN  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Age;assay development;Benign;Biological;Biological Assay;Body Fluids;cell free DNA;Cells;Cholesterol;Clinical;clinical care;clinical investigation;clinical translation;clinically relevant;computed tomography screening;Consensus;cost;Cryopreservation;Data Analyses;Density Gradient Centrifugation;design;Detection;detection limit;detection sensitivity;Devices;Diagnosis;diagnostic accuracy;Diameter;Differential Diagnosis;Disease;DNA;DNA Library;DNA Sequence Alteration;Early Diagnosis;Encapsulated;Epidermal Growth Factor Receptor;Etiology;Evolution;extracellular vesicles;Female;Future;Gene Frequency;Gene Mutation;gene panel;Gene Targeting;Genes;genetic information;Genomics;Goals;Health Care Costs;healthcare burden;Height;Heterogeneity;High-Throughput Nucleotide Sequencing;Image;imaging modality;Incidence;iodixanol;KRAS2 gene;Length;Lesion;Libraries;liquid biopsy;Lung;Lung Adenocarcinoma;lung cancer screening;male;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Medical Imaging;meter;Methods;microdevice;Microspheres;Modality;Molecular;Molecular Analysis;molecular diagnostics;Mutation;Mutation Analysis;Neoplasm Metastasis;next generation sequencing;non-smoker;Normal tissue morphology;Nucleic Acids;operation;Patients;Pattern;Performance;Periodicals;Plasma;Plasma Proteins;Preparation;pressure;Probability;Process;Proteins;Pulmonary Coin Lesion;rapid diagnosis;rapid test;Reproducibility;Risk;RNA;Role;Sampling;Sensitivity and Specificity;sequencing platform;sex;Smoker;Smoking History;Specificity;targeted sequencing;Temperature;Testing;Time;Tissue Sample;Tissues;Translating;tumor;tumor progression;Tumor Tissue;United States;vesicular release;Visit;Width

PROJECT_TITLE: Liquid biopsy of solitary pulmonary nodule with extracellular vesicles


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Precision Medicine;Prostate Cancer;Radiation Oncology;Urologic Diseases

PHR: NARRATIVE More than ten percent of patients with high-risk prostate cancer carry mutations in DNA repair genes in their blood; these cancers are more likely to stop responding to standard treatment early, spread to other organs, and lead to death. The researchers propose a clinical trial to treat these cancers at an earlier stage with a drug that targets these mutations (niraparib), as well as with hormonal therapy, surgery, and radiotherapy. This trial will study the mutations in the cancers before and after treatment to learn which patients are likely to benefit most from this treatment approach, and to find the best combination of drugs to treat these lethal prostate cancers that have aggressive mutations.

PI_NAMEs: SCHER, HOWARD I (contact)

PROJECT_TERMS: abiraterone;Acceleration;Acetates;actionable mutation;Aftercare;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;arm;Attenuated;Beds;biomarker identification;Blood;Blood specimen;brca gene;BRCA2 gene;cell free DNA;Cessation of life;Classification;Clinical;Clinical Trials;Clinical Trials Design;cohort;Combined Modality Therapy;Complement;Dana-Farber Cancer Institute;Data;Development;Diagnostic;Disease;Disease remission;DNA analysis;DNA Double Strand Break;DNA Repair;DNA Repair Gene;Drug Combinations;drug development;Drug resistance;drug sensitivity;Drug Targeting;Early treatment;Educational workshop;Evaluation;Event;exceptional responders;exome sequencing;experience;flexibility;Frequencies;Future;gene repair;Genes;genomic profiling;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Grant;Guidelines;high risk;hormone therapy;Immune;improved;In complete remission;inhibitor;insight;Learning;Lesion;Local Therapy;Localized Disease;Loss of Heterozygosity;Lymph Node Dissections;lymph nodes;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Memorial Sloan-Kettering Cancer Center;men;Metastatic Neoplasm to the Prostate;Molecular;Molecular Profiling;Monitor;multimodality;Mutate;Mutation;National Comprehensive Cancer Network;Neoplasm Metastasis;novel;Operative Surgical Procedures;Organ;palliation;PARP inhibition;participant enrollment;Pathologic;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Pelvis;Pharmaceutical Preparations;Pharmacologic Substance;Poly(ADP-ribose) Polymerase Inhibitor;Postoperative Period;potential biomarker;predictive marker;Probability;Prognosis;programs;prospective;Prostate;prostate biopsy;prostate cancer risk;Protocols documentation;Radiation;Radiation therapy;Radical Prostatectomy;Randomized;Receptor Signaling;Recovery;Recurrence;Relapse;Reporting;Research Personnel;Residual Neoplasm;Residual state;Resistance;responders and non-responders;response;response biomarker;Risk;Science;Selection for Treatments;Site;Somatic Mutation;standard care;Structure;synergism;Systemic Therapy;targeted treatment;Testing;Testosterone;Therapeutic;Time;Tissue Sample;transcriptome sequencing;transcriptomic profiling;Translational Research;treatment arm;treatment effect;trial comparing;trial enrollment;tumor;Tumor Burden;tumor DNA;Tumor Tissue;Variant;Writing

PROJECT_TITLE: Targeting the DNA Damage Repair Pathway in Non-Castrate Prostate Cancers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project relevance The proposed research aims to develop new optical microscopy methods that will significantly expand the applications of single molecule measurement methods for in vitro, live cell and in vivo studies. These methods will enable unprecedented control in the introduction of molecules and nanoparticles into cells or onto cell membranes, allow single molecule fluorescence resonance energy transfer (smFRET) with time resolution of ≤ 100? ? , and smFRET will be developed to reach across live cell membranes. A prototype instrument will have been constructed that will allow the observation of sub-nanometer movement of live cell and in vitro systems with 100 ? ?  time resolution.

PI_NAMEs: CHU, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: 3-Dimensional;Address;Animals;Axon;Biological;biological research;biological systems;Biophysics;cell injury;Cell membrane;Cells;Cellular Structures;Cryoelectron Microscopy;Cytosol;Data;Detection;Development;Devices;Dyes;Dynein ATPase;Endocytosis;Enzymes;extracellular;Feedback;Fluorescence;Fluorescence Resonance Energy Transfer;Funding;Genes;GTP-Binding Proteins;Hour;Image;improved;In Situ;In Vitro;in vivo;Individual;infrared microscopy;insight;instrument;instrumentation;Kinetics;Label;laser tweezer;Ligand Binding;Light;Measurement;Measures;Membrane Proteins;Methods;Microfluidics;Microscope;Microscopy;millimeter;millisecond;Modeling;Molecular;molecular imaging;Molecular Motors;molecular scale;Molecular Structure;Motion;Movement;nanometer;nanoparticle;nanoscale;Neurons;new technology;novel;optic tweezer;Optics;Organism;particle;Pathway interactions;Photobleaching;Photons;Physics;plasmonics;Power stroke;prevent;Process;professor;promoter;Proteins;prototype;receptor;Research;Research Personnel;Resolution;response;Roentgen Rays;Side;Signaling Protein;single molecule;single-molecule FRET;Spatial Distribution;superresolution microscopy;Surface;Survival Rate;Synapses;System;technique development;Technology;temporal measurement;Testing;Time;Tissues;tool;Transfection;ultra high resolution;Vesicle;Virus;Visualization;Work

PROJECT_TITLE: Extending the temporal and spatial capabilities of single-molecule methods

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]