NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PHR: Project Narrative The 3D chromatin architecture of retinal cells is important for understanding how neuronal cell lineage commitment is established. Previous epigenetic and transcriptomic studies of retinal development suggest that changes in chromatin organization precede changes in cell state, however, a direct link between these processes has not been established. This research proposal will characterize the chromatin organization of retinal cells at the single-cell level, establish an integrated dataset of both chromatin organization and transcription at the single-cell level during retinal development, which will in turn be used to improve our understanding of gene regulatory networks that control retinal development.

PI_NAMEs: TRINH, VICKIE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Atlases;Binding;Cell Fate Control;cell fate specification;Cell Lineage;cell type;Cells;Central Nervous System;ChIP-seq;Chromatin;Chromatin Loop;chromatin remodeling;Chromatin Structure;Chromium;Chromosome Structures;Competence;conditional knockout;Data;data integration;Data Set;Development;Enhancers;Epigenetic Process;epigenomics;Family;Gene Expression;gene regulatory network;Genes;Genetic Transcription;Genome;Genome Mappings;genome-wide;genome-wide analysis;Genomics;Hi-C;improved;Individual;Knockout Mice;Link;loss of function;Mediating;Methods;Microfluidics;Muller's cell;Multiomic Data;multiple omics;Mus;network models;neuron development;Neurons;NFIA gene;novel;novel strategies;nuclear factor 1;Pattern;Photoreceptors;Play;Process;Protocols documentation;Regulatory Element;Research;Research Proposals;Resolution;Retina;Retinal Diseases;retinal neuron;retinal progenitor cell;retinal rods;retinogenesis;Rod;Role;single cell ATAC-seq;single cell sequencing;single cell technology;single-cell RNA sequencing;Sorting;Specific qualifier value;Structure;Study models;System;Technology;transcription factor;transcriptome sequencing;transcriptomics;Transitional Cell

PROJECT_TITLE: Understanding the chromatin architectural landscape of retinal development at the single-cell level


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative The average adult generates >2 million red blood cells per second. The process of generating a mature red blood cell from a committed progenitor is complex, and defects in this process result in anemia. The goal of this proposal is to understand how the Integrator complex, an important regulator of the transcription machinery, controls red blood cell production.

PI_NAMEs: STEINER, LAURIE A. (contact);WAGNER, ERIC J

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Adult;alpha Globin;Anemia;Attenuated;beta Globin;Binding;Biochemical;Biological Assay;Biology;Cell Nucleus;Cell Physiology;Cells;Cleavage Under Targets and Release Using Nuclease;Code;Complex;Data;Defect;Endoribonucleases;Enhancers;Erythroblasts;Erythrocytes;Erythroid;Erythroid Cells;erythroid differentiation;Erythropoiesis;functional genomics;Gene Expression;gene repression;Genes;Genetic Transcription;Genomics;Goals;Hematology;Homeostasis;Human;Impairment;insight;Knowledge;Laboratories;Mediating;Messenger RNA;Modeling;novel;Phosphoric Monoester Hydrolases;Phosphorylation;Preparation;prevent;Process;Production;progenitor;programs;Proliferating;promoter;protein expression;Protein phosphatase;Regulation;Research;Research Personnel;Resource Allocation;RNA;RNA Polymerase II;RNA Processing;Role;Scientist;senescent cell;System;Testing;Transcript;transcription termination;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Elucidating the Role of Integrator Complex in Erythropoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking;Women's Health Research

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: PROJECT NARRATIVE Adolescent alcohol exposure is associated with adult behavioral deficits, such as increased risk-taking and psychiatric disorders. I will examine how adolescent binge drinking causes sex differences in prelimbic somatostatin neuronal regulation of behavior, and I will test the therapeutic potential of targeting this population for prevention of adolescent alcohol’s long-term consequences. This application combines novel technological approaches with understudied questions surrounding adolescent binge drinking and its lasting effects on cortical microcircuits.

PI_NAMEs: SEEMILLER, LAUREL  (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;addiction;Adolescence;Adolescent;adolescent alcohol effect;adolescent alcohol exposure;adolescent binge drinking;Adult;aged;Alcohol consumption;alcohol exposure;alcohol research;Alcohols;Bathing;Behavior;behavior change;behavior test;Behavioral;behavioral pharmacology;Brain;brain health;Calcium;career;Chronic;chronic alcohol ingestion;Cognitive;Collection;Consumption;D Cells;Darkness;Data;Data Analyses;Development;Disinhibition;drinking;Drug Modulation;drug of abuse;druggable target;Electrophysiology (science);Engineering;experience;experimental study;Exploratory Behavior;Female;Future;gamma-Aminobutyric Acid;Health;Home;Human;Imaging Techniques;Impaired cognition;in vivo;in vivo evaluation;in vivo imaging;Intervention;L-Type Calcium Channels;Laboratories;male;Mental disorders;Mentors;Mentorship;Monitor;mouse model;Mus;neural;Neurobiology;neuroimaging;neuronal excitability;Neurons;Neurosciences;neurotransmission;new technology;optical imaging;Outcome;patch clamp;pharmacologic;Photons;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-clinical;prevent;Prevention;Problem behavior;Productivity;Qualifying;Regulation;Reporting;Research;Risk;Risk Taking;Role;sex;Sex Differences;Signal Transduction;Slice;Somatostatin;Substance Use Disorder;System;Target Populations;Techniques;Testing;therapeutic evaluation;Time;Training;Transgenic Mice;underage drinking;Up-Regulation

PROJECT_TITLE: Sex differences in somatostatin cell dynamics and exploratory behavior after adolescent binge drinking in mice

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE By studying how loss of NXF2 leads to male infertility and discovering if the NXF2 protein has gained a novel function, I will increase our understanding of which proteins are important in regulating RNA transport. If my hypothesis is correct, I will increase our understanding of testicular germ cell biology through discovering a member of a highly conserved nuclear export gene family has evolved a completely novel function only in testicular germ cells. My studies of mouse NXF2 in fertility defects will help inform cases of human male infertility associated with NXF2 mutations.

PI_NAMEs: LAWSON, ANN MARIE (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Affinity;age related;Backcrossings;Binding;Biochemical;Biological Assay;Biology;Cell Nucleus;Cell Physiology;Cells;Cellular biology;Cytoplasm;Data;Defect;Detection;Development;DNA;Drosophila genus;Eukaryota;Exhibits;Exons;Fertility;Fertility Disorders;gene conservation;Gene Duplication;Gene Family;Generations;Genes;Genetic;Genetic Transcription;Genomic approach;Germ Cells;Germ Lines;Homeostasis;human male;Hybrids;Immunologics;improved;Infertility;Link;Maintenance;male;male fertility;Male Infertility;Mammals;Mediating;Meiosis;member;Microscopy;Modeling;Molecular;mouse model;Mus;Mutation;novel;Nuclear Export;Nuclear Pore;Nuclear RNA;paralogous gene;Pattern;Penetrance;Phenotype;Play;Positioning Attribute;progenitor;Proteins;Proteomics;Regulation;Resolution;RNA;RNA Binding;RNA Recognition Motif;RNA Stability;RNA Transport;Role;single cell sequencing;Somatic Cell;Spermatocytes;Spermatogenesis;subfertility;Techniques;Testing;Testis;transcriptomics;Translating;Yeasts

PROJECT_TITLE: NXF2-mediated RNA transport in the male germline

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE: Survivors of critical illness often exhibit new and persistent impairments following hospitalization, which may require specialized follow-up care. Methods employed to identify patients who may benefit from advanced interventions, such as a post-acute care clinic, include risk prediction tools, which are subject to bias. Our project endeavors to investigate healthcare disparities among survivors of critical illness within statistical modeling set the groundwork for delivering personalized and equitable care following critical illness, and provide a comprehensive training plan for an F32 candidate.

PI_NAMEs: NAIDITCH, HIAM  (contact)

PROGRAM_OFFICER_NAME: GOGINENI, ARUNDHATI

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Acute Physiology and Chronic Health Evaluation;Address;Affect;black patient;Black race;Calibration;Cardiovascular Diseases;care costs;care delivery;career;Caring;Clinic;cohort;Consultations;COVID-19;Critical Care;Critical Illness;Data;Data Set;Databases;design;Discrimination;Disparity;Equity;ethnic diversity;Ethnic Origin;Ethnic Population;Exhibits;experience;Family member;follow-up;Foundations;functional outcomes;Future;future implementation;Grant;Health;health care delivery;health care disparity;Health Services Research;Healthcare Systems;high risk;Hispanic;hospital readmission;Hospitalization;Hospitals;Impaired cognition;Impairment;implementation intervention;improved;Inequality;innovation;Inpatients;Intensive Care Units;Intervention;Intervention Studies;K-Series Research Career Programs;Knowledge;Measures;Mentorship;Methods;model development;Modeling;mortality;mortality risk;Needs Assessment;neurocognitive disorder;novel strategies;Organ failure;Outcome;Outpatients;Palliative Care;patient population;patient stratification;Patient-Focused Outcomes;Patients;Performance;Phase;physically handicapped;Physicians;Population;prediction algorithm;predictive modeling;predictive tools;prognostication;Public Policy;Qualifying;Race;racial difference;racial disparity;racial diversity;racial population;readmission rates;Research;Research Methodology;respiratory;Risk;risk prediction;risk prediction model;Role;Scientist;Severity of illness;social factors;Societies;Source;Statistical Algorithm;Statistical Models;Structure;Survivors;tool;Training;Underrepresented Populations;Universities;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Examining Racial Disparities in Predictive Modeling Among Survivors of Critical Illness

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease;Microbiome;Urologic Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Catheter-associated urinary tract infections (CAUTIs) are one of the most common healthcare associated infections worldwide and are often polymicrobial with the most common co-colonizing bacteria being P. mirabilis, E. coli, and E. faecalis. Polymicrobial studies have demonstrated mutualistic interactions that lead to an enhancement in biofilm formation that contributes to the disease progression of CAUTIs. Understanding the factors that allow for enhancement of triple species biofilms and progression of disease within the catheterized urinary tract has the potential to guide future therapeutic prevention and intervention in CAUTIs.

PI_NAMEs: TADDEI, STEVEN MARCEL (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Antibiotic Resistance;Architecture;Bacteremia;Bacteria;Bacterial Adhesins;bacterial community;biofilm species;Biological Assay;Biomass;Bladder;Bladder Calculi;catheter associated UTI;Catheterization;Catheters;co-infection;Coculture Techniques;Communities;Coupled;Data;Disease Progression;Drainage procedure;Elderly;Enterococcus faecalis;Escherichia coli;Exhibits;extracellular;fimbria;Fluorescence Microscopy;Future;Glass;Growth;Harvest;Healthcare;healthcare-associated infections;Hour;Human;Immune system;Immunocompromised Host;in vitro Assay;Incidence;Indwelling Catheter;Infection;insight;interest;Intervention;Kidney;Kidney Calculi;Knowledge;Link;Literature;Mediating;Mediator;Metabolism;Microbe;Microbial Biofilms;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mutant;mutualism;pathogen;Pathogenesis;Pathogenicity;Patients;Physiological;Polymers;polymicrobial biofilm;Prevention;Process;Production;Proteins;Proteus mirabilis;Recurrence;recurrent infection;renal damage;Research;Resolution;Risk;Scanning Electron Microscopy;Severities;Severity of illness;Spatial Distribution;Spleen;Structure;System;Testing;Therapeutic;urinary;Urinary Catheterization;Urinary tract;Urinary tract infection;Urine;urolithiasis;Uropathogen;Virulence Factors;Vulnerable Populations;Work

PROJECT_TITLE: Building a community: examining polymicrobial Interactions within urinary catheter biofilms and their contribution to infection severity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: LAWRENCE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it contributes to our understanding of reciprocal communication in nonspeaking autistic children in caregiver-child interactions. This project will assess how common caregiver interaction strategies, namely multimodal communication and imitation, promote moment- to-moment changes in reciprocity and how child receptive language impacts the relationship between caregiver strategies and reciprocal interaction. This project reflects the NIDCD's mission to improve the lives of individuals with communication disorders by improving our understanding of mechanisms of social interaction in nonspeaking autistic children, which may lead to future advancements in communication interventions for this population.

PI_NAMEs: BOOROM, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 6 year old;Address;Age;autism spectrum disorder;autistic children;Behavior;behavior influence;Behavior Therapy;Behavioral;Benchmarking;Caregivers;Characteristics;Child;Classification;Clinical;cohort;Communication;Communication impairment;Data;design;Development;Dimensions;Distal;dyadic interaction;Effectiveness;executive function;experience;Frequencies;Future;Gestures;Goals;Heterogeneity;Home;improved;Individual;Individual Differences;individual variation;individualized medicine;innovation;insight;Intervention;intervention effect;intervention refinement;Knowledge;Language;Language Development;language outcome;Learning;Link;Measures;Methods;minimally verbal;Mission;multimodality;National Institute on Deafness and Other Communication Disorders;Nature;non-verbal;Outcome;Parents;Pathway interactions;Pattern;personalized approach;Play;Population;Population Intervention;Public Health;Quality of life;Reciprocal Social Interaction;Research;Risk;Sampling;Shapes;skills;social engagement;Social Interaction;Testing;Time;tool;Treatment outcome;treatment program;treatment strategy;verbal;vocalization;Work

PROJECT_TITLE: Understanding how caregivers shape reciprocal communication with nonspeaking autistic children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Real-life decisions are often context-dependent- you might decide to grab an umbrella on a sunny day if you heard a forecast of rain or sunglasses if you did not. In this study, I will leverage whole-brain and cellular-level imaging techniques to reveal how the mammalian brain keeps contextual information in mind to flexibly guide decision-making. By advancing our understanding of the neurobiology of this higher-order cognitive process, this proposal will facilitate the identification of new therapeutic targets for psychiatric disorders in which context-dependent decision-making is impaired, including schizophrenia and post-traumatic stress disorder.

PI_NAMEs: GRUSKIN, DAVID COURT (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acceleration;Address;Anatomy;Animal Model;Animals;Anterior;Area;Behavior;Behavioral;behavioral impairment;behavioral response;Brain;brain based;Brain imaging;Calcium;cingulate cortex;Clinical;Cognition;cognitive control;cognitive process;Communities;Complex;Cues;Decision Making;Development;Disease;experimental study;flexibility;frontal lobe;Functional Magnetic Resonance Imaging;Future;Genetic;Goals;Health;Hearing;Human;human model;Image;imaging study;Imaging Techniques;Impairment;insight;Lateral;Left;Life;Light;Link;Location;Maintenance;Maps;Mental disorders;Mind;Motor;Mus;neural;Neurobiology;Neurons;new therapeutic target;novel;novel therapeutics;Odors;optogenetics;Parietal Lobe;Pattern;Performance;Physicians;Police;Population;Post-Traumatic Stress Disorders;preclinical study;Process;Professional Competence;Rain;Research;response;Rewards;Rodent;Role;Schizophrenia;Scientist;sensor;Sensory;sensory stimulus;Shapes;sunglasses;System;Task Performances;Technical Expertise;Testing;Thalamic structure;Training;two photon microscopy;Water;Work

PROJECT_TITLE: Multiscale imaging of context-dependent decision-making


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: PROJECT NARRATIVE The Gordon Research Conference on Bacterial Cell Surfaces and accompanying Gordon Research Seminar will bring together junior researchers, leaders of the bacterial envelope field, and members of the pharmaceutical industry to discuss cutting-edge research and the most-pressing questions about the bacterial cell surface and its impact on human health and disease. The conference will focus on disseminating the latest research on how the bacterial cell surface is built, adapts, evolves, and interacts with the outside world, as well as on the development of much-needed novel antibacterial strategies that target the cell envelope of disease-causing bacteria.

PI_NAMEs: RUIZ, NATIVIDAD  (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TERMS: Academia;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Automobile Driving;Bacteria;Bacterial Drug Resistance;Bacterial Infections;Bacterial Physiology;Bacteriophages;Basic Science;Behavior;Biochemistry;Biogenesis;Biological Models;Biology;Biophysics;career;Cell division;cell envelope;Cell Maintenance;Cell Physiology;Cell surface;Cells;Cellular biology;Collaborations;collaborative environment;combat;Communicable Diseases;Communities;demographics;Development;Disease;Disease Resistance;diversity and inclusion;Drug Industry;educational atmosphere;Ensure;Environment;Evolution;fighting;Fostering;Future;Generations;Genetic;Goals;graduate student;Gram-Negative Bacteria;Growth;Health;host microbiome;host-microbe interactions;Hour;Human;Human Microbiome;Image;Immune system;Infection;informal atmosphere;insight;interest;Knowledge;Maintenance;Mediating;Medical;meetings;member;microbiome;microbiota;Mission;Modeling;Modification;Molecular;Morphogenesis;Nature;new technology;novel;novel strategies;Oral;Organism;Outcome;Participant;Pathogenicity;peer;Permeability;Postdoctoral Fellow;posters;programs;Research;Research Personnel;Resort;Scientist;structural biology;Structure;Surface;symposium;Technology;Translational Research;United States National Institutes of Health;vaccine development;Voting;Work;Workplace

PROJECT_TITLE: Bacterial Cell Surfaces Gordon Research Conference and Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 LK-D (J1)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Prevention;Rare Diseases;Sickle Cell Disease;Stroke

ORG_CITY: Nashville

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Sickle cell anemia (SCA) is the most common and severe form of sickle cell disease and predisposes individuals for increased lifelong risk for stroke or brain injury. While protocols exist for children, there are currently no validated screening protocols for assessing stroke risk in adults with SCA. This project focuses on using novel proposed neuroimaging biomarkers to characterize brain health in adults with SCA and to assess how these biomarkers change after treatments that are known to reduce stroke risk; findings are intended to provide new information on the mechanisms contributing to brain injury in SCA with the long-term goal of using this information to triage patients for appropriate treatments.

PI_NAMEs: SONG, ALEXANDER K (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;African American population;Aftercare;Age;Anemia;arterial spin labeling;Atherosclerosis;Biological Markers;Blood;Blood capillaries;Blood Transfusion;Blood Vessels;Brain;brain health;Brain Injuries;cerebral hemodynamics;Cerebral Infarction;Cerebrovascular Circulation;Cerebrum;Child;Chronic;Clinical;Clinical Research;Clinical Trials;Cognitive deficits;Compensation;curative treatments;Data;data acquisition;design;Development;Disease;Doctor of Philosophy;Eligibility Determination;Equilibrium;Erythrocytes;Exhibits;experience;faculty support;Functional disorder;Funding;Goals;Health;Hematology;hemodynamics;Hemoglobin;Hemolytic Anemia;high risk;Human;image processing;imaging modality;imaging science;improved;Individual;Infarction;Injury;Ischemia;Jordan;Label;Magnetic Resonance Imaging;Measurement;Measures;Medicine;Mentors;Metabolic;Methodology;Methods;Modeling;Monitor;mutant;neuroimaging;neuroimaging marker;Neurology;Noise;non-invasive imaging;novel;Oxygen;Oxygen Consumption;Patient Triage;Patients;Persons;Physiologic pulse;Physiology;potential biomarker;Prospective Studies;Protocols documentation;Recovery;Relaxation;Reporting;Risk;Risk Assessment;Risk Factors;Risk Reduction;Secondary to;Severities;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;Signal Transduction;Slice;statistics;Stroke;stroke risk;stroke therapy;Testing;Time;tissue oxygenation;Tissues;Training;Transfusion;treatment response;United States;United States National Institutes of Health;Variant;Water;Work

PROJECT_TITLE: Cerebral oxygen extraction efficiency in patients with sickle cell anemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Neonatal Respiratory Distress;Orphan Drug;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Public Health Relevance Statement Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by an imbalance of lung injury and repair in developing immature lungs of premature infants and affects over 10,000 premature infants in the United States every year. These critically ill premature infants often require mechanical ventilation as a lifesaving measure, and effective disease management includes an individualized approach to choosing the right ventilation strategy and medications. This proposal will develop Electrical Impedance Tomography (EIT) technology to provide real- time feedback to guide the clinician in the treatment strategy in infants with BPD.

PI_NAMEs: MUELLER, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Affect;Age;Air;Airway Resistance;Algorithms;Biological Markers;Birth;Blood flow;Breathing;Bronchodilator Agents;Bronchopulmonary Dysplasia;Caring;Chronic lung disease;Clinical;Clinical Research;Collaborations;Colorado;comorbidity;Computer software;Critical Illness;Data;design;Diagnosis;Disease Management;Dysbarism;Effectiveness;effectiveness evaluation;effectiveness measure;efficacy evaluation;electrical impedance tomography;Electrocardiogram;Enrollment;experience;Feedback;Functional Imaging;Gestational Age;Heart Rate;Hospitals;Image;image visualization;Imaging Techniques;improved;Incidence;indexing;individualized medicine;Infant;innovation;Institution;Intubation;Life;Lung;Lung Diseases;lung imaging;lung injury;lung repair;Measurement;Measures;Mechanical ventilation;member;Methods;Morbidity - disease rate;Neonatal Intensive Care Units;neonate;novel;Observational Study;Output;Patients;Pattern;Pediatric Hospitals;Perfusion;personalized approach;Pharmaceutical Preparations;Pharmacologic Substance;Positive-Pressure Respiration;premature;Premature Infant;premature lungs;pressure;Procedures;prospective;Protocols documentation;public health relevance;Pulmonary Hypertension;Pulsatile Flow;real-time images;reconstruction;Research;Research Personnel;Resistance;Risk;side effect;Staging;success;System;Techniques;Technology;Three-Dimensional Image;Three-Dimensional Imaging;Time;tomography;Tracheobronchomalacia;translational study;Treatment Effectiveness;treatment planning;treatment strategy;United States;Universities;ventilation;Ventilator;Ventilator-induced lung injury;Visualization

PROJECT_TITLE: Real-time EIT pulmonary imaging for infants requiring ventilatory therapy

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Genetics;Lung;Regenerative Medicine

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Chronic Respiratory Diseases, such as Chronic Obstructive Pulmonary Disease (COPD), are the third leading cause of death and disability in the United States, generating $50 billion dollars in expenses every year. There are no cures for this disease group. We want to study lung healing so that we can develop new treatments to help people with Chronic Respiratory Diseases.

PI_NAMEs: PANTUCK, MORGAN  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Affect;alpha ketoglutarate;alveolar epithelium;ATAC-seq;Binding;Biological;Calcium;Cause of Death;Cell Differentiation process;cell injury;Cells;Chromatin;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Citric Acid Cycle;Cleavage Under Targets and Release Using Nuclease;Clinical Medicine;Complex;Country;CRISPR/Cas technology;Cytoplasm;Data;Defect;demethylation;Dependovirus;Development;disability;Disease;Doctor of Philosophy;economic cost;Effector Cell;Ensure;Epigenetic Process;experimental study;Failure;Gases;Gatekeeping;Gene Deletion;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Grant;Guide RNA;healing;health economics;histone demethylase;Histone H3;histone methylation;Histones;In Vitro;in vivo;inhibitor;Injury;Institution;interest;Knock-out;Link;Location;Lung;lung injury;lung regeneration;lung repair;Lysine;Measures;Mediating;medical schools;Messenger RNA;Metabolic;Metabolism;Methylation;Mitochondria;Mitochondrial Matrix;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;novel;novel strategies;novel therapeutic intervention;Oxidoreductase;Pathogenesis;Patients;Persons;pharmacologic;Process;Production;programs;Proliferating;Proteins;Public Health;pulmonary function;Reaction;Research;Signal Transduction;stem cell population;success;Succinates;Supplementation;tissue regeneration;Training;transcription factor;transcriptome sequencing;translational medicine;treatment strategy;United States;Universities;uptake

PROJECT_TITLE: Linking Mitochondrial Calcium to Histone Methylation Underlying Lung Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative As the most common primary brain malignancy, glioblastoma (GBM) carries poor prognosis and insights into tumor biology in the context of the normal brain environment are desperately needed to define new therapeutic strategies. Using a patient-derived GBM organoid model, this proposal seeks to repurpose monosynaptic rabies viral tracing in the adult mouse brain for understanding the circuit connectivity of GBM, aided by a combination of calcium imaging, optogenetics, electrophysiology, and RNA sequencing. Our findings will define the diverse brain circuitry that interacts with GBM and harness this knowledge to propose novel therapeutic targets for this disease, such as the metabotropic cholinergic receptors.

PI_NAMEs: SUN, YUSHA  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acetylcholine;Address;Adult;Anatomy;Animals;Architecture;Area;Axon;basal forebrain;basal forebrain cholinergic neurons;Basic Science;Behavior;bench to bedside;Biological Assay;Brain;brain circuitry;Brain Neoplasms;Brain region;Calcium;Calcium Signaling;Cancer Biology;Career Choice;Cell Line;cell motility;Cell Proliferation;cell type;Cells;Central Nervous System;cholinergic;cholinergic neuron;Cholinergic Receptors;CHRM3 gene;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cognitive function;Complex;connectome;Data;Development;Disease;Disease Progression;Electrophysiology (science);Environment;Functional disorder;Glioblastoma;Glioma;Glutamates;Goals;Helper Viruses;Heterogeneity;Human;human model;Image;Immunodeficient Mouse;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;in vivo Model;insight;Knowledge;Label;Location;Malignant neoplasm of brain;Malignant Neoplasms;Maps;Mediating;medical schools;Membrane;Methodology;Methods;migration;Modeling;Molecular;mouse model;Mus;Muscarinic M3 Receptor;neoplastic cell;neural;neural circuit;neuronal excitability;Neurons;neuroregulation;Neurosciences;neurotransmission;Neurotransmitters;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;optogenetics;organoid transplantation;Organoids;Outcome;paracrine;Pathogenesis;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Pennsylvania;Physicians;Play;Population;preservation;Prognosis;programs;Proliferating;Property;Proteins;Rabies;rabies viral tracing;Rabies virus;receptor;Regulation;Reporting;Research;Role;Scientist;Signal Transduction;Simplexvirus;single-cell RNA sequencing;small hairpin RNA;Specificity;Specimen;stem cells;Synapses;Testing;Therapeutic;Time;Tissues;Training;transcriptional reprogramming;transcriptome sequencing;transcriptomics;transmission process;Transplant Recipients;Transplantation;tumor;Tumor Biology;Tumor Cell Invasion;tumor heterogeneity;tumor progression;Universities;voltage;Work;Xenograft procedure

PROJECT_TITLE: Monosynaptic tracing defines circuit connectivity of human high-grade glioma in the adult mouse brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01A-V (20)]


ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The development of single-cell Erk biosensors and single-cell RNA sequencing has revealed that Erk activity is heterogeneous: both in transcriptional activity and temporally, with some cells exhibiting complex Erk-signaling dynamics. Using novel biosensors, high-resolution live-imaging, 3D models of mammalian development, and scalable CRISPR-screening approaches, this work proposes to interrogate how single-cells integrate Erk activity and gene-expression programs, in addition to addressing the mechanisms that generate single-cell Erk signaling dynamics. Erk signaling is responsible for many cellular decisions, including the evolution of drug-resistant cancer cells, therefore an understanding of the precise behavior and regulation of Erk activity at the single-cell level will directly inform chemotherapeutic drug development.

PI_NAMEs: SOLLEY, SABRINA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Area;Behavior;Biological;Biosensor;Cancer Biology;cancer cell;career;cell behavior;Cell Differentiation process;cell motility;Cell Therapy;Cells;clinical application;Communication;Communities;Complex;Core Facility;Coupled;CRISPR screen;Cues;Data;Data Collection;Decision Making;Development;Disease;drug development;Drug resistance;dynamic system;Early Gene Transcriptions;Embryonic Development;Engineering;Environment;ERG gene;Evolution;Exhibits;experimental study;Feedback;Future;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;genome wide screen;genome-wide;Genomic approach;Genomics;Growth and Development function;Heritability;Heterogeneity;Image;Immediate-Early Genes;in vivo;insight;Laboratories;live cell imaging;Malignant Neoplasms;Measurement;Mediating;Mentorship;Methods;Modernization;Molecular;Molecular Biology;next generation sequencing;novel;Outcome;Pathway interactions;PC12 Cells;Phenotype;Phosphotransferases;Physiologic pulse;Population;programs;Proliferating;Property;Regulation;Research;Research Personnel;Research Training;Resolution;Resources;response;Running;Signal Pathway;Signal Transduction;single-cell RNA sequencing;skills;Source;Supervision;supportive environment;synthetic biology;Technology;Therapeutic;three-dimensional modeling;Training;transcriptome sequencing;transcriptomics;Universities;Work;wound healing

PROJECT_TITLE: Characterizing the interpretation and generation of Erk signaling dynamics using high-throughput genetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Pediatric;Violence Research;Youth Violence

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE Children who exhibit externalizing behaviors are at significant and enduring risk for experiencing subsequent substantial psychological difficulties which carry substantial societal and economic costs. Although callous- unemotional traits are consistent risk factors for externalizing problems, there is limited research identifying explanatory processes of this association. The present study leverages a multimethod, multi-informant, multilevel, longitudinal approach to examine attention to emotions, emotion knowledge, and physiological reactivity to challenges as mediators of the relation between children’s early CU traits and subsequent externalizing behaviors.

PI_NAMEs: CAO, VANESSA T (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;Adult;Aggressive behavior;Anger;Area;Attention;attentional bias;Attentional deficit;Behavior;Behavioral;Biological;callous unemotional trait;Child;Child Care;Clinical;Cognitive;conduct problem;Cues;Data;Depressed mood;design;Development;early childhood;Early identification;economic cost;Emotional;Emotions;Empathy;Environment;Equation;Exhibits;experience;externalizing behavior;Face;Facial Expression;Family;Financial cost;Guilt;Happiness;Hyperactivity;Impairment;improved;informant;information processing;Intervention;Investigation;Knowledge;Literature;Longitudinal Studies;Measurement;Mediating;Mediator;Methodology;Methods;metropolitan;Modeling;Mothers;Motivation;Mydriasis;Ocular Physiology;Parasympathetic Nervous System;Pathogenicity;Pathway interactions;perspective taking;Physiological;Preschool Child;Problem behavior;Process;prospective;psychologic;psychopathic personality;recruit;Research;Research Design;Resources;respiratory;response;Risk;Risk Factors;Role;Sinus Arrhythmia;societal costs;Societies;Surveys;Sympathetic Nervous System;Symptoms;teacher;Testing;Theoretical model;tool;visual tracking;Withdrawal;Work

PROJECT_TITLE: Identifying Risk Mechanisms Underpinning the Association Between Callous-Unemotional Traits and Externalizing Behavior


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative from Parent Award Cell-adhesion receptors are key molecules for cellular communication and have emerging functions in numerous cellular processes. The research proposed in this application will yield key insights into fundamental molecular mechanisms that underlie the function of two poorly understood families of cell-adhesion receptors in multicellular organisms (namely the 33 adhesion G Protein-Coupled Receptors (aGPCRs) and the four teneurins). This research will provide critical knowledge into the molecular mechanisms of intercellular communication, and since many aGPCRs and teneurins are found mutated in neurological disorders and cancers, this research is expected to provide crucial clues for the development of novel strategies to understand and treat these disorders.

PI_NAMEs: ARAC-OZKAN, DEMET  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: adhesion receptor;Adhesions;Biochemical;Biological Assay;Biophysics;brain malformation;Cell Adhesion;Cell Physiology;Cell Surface Receptors;Communication;Communities;Complex;Development;developmental disease;Disease;Eukaryota;Evolution;extracellular;Family;FDA approved;Future;G-Protein-Coupled Receptors;Genetic study;Goals;Heart;human disease;insight;intercellular communication;interdisciplinary approach;Knowledge;Ligands;Link;Malignant Neoplasms;malignant neurologic neoplasms;Mediating;Molecular;Mutagenesis;Mutate;Nature;nervous system development;Nervous System Disorder;novel strategies;Organism;parent project;Pharmaceutical Preparations;Physiological;programs;Protein Engineering;receptor;receptor function;Research;Role;Signal Transduction;Skeletal system;Structure;success;Testing;Therapeutic;three dimensional structure;tool;Work

PROJECT_TITLE: Structural and Functional Studies of Cell-Adhesion Receptors

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PHR: Project narrative Categorization is an important cognitive function that underlies our ability to assign the same behavioral output to a variety of sensory inputs, and deficits in categorization have been observed in a number of neurological disorders. This project will use large-scale electrophysiological recordings and reversible inactivation to investigate the circuit mechanisms that mediate categorization behavior. The insight gained from this work will advance our understanding of mechanisms of category representation and flexible cognition, and enhance our ability to detect and treat brain disorders that disrupt categorization systems.

PI_NAMEs: COOLEY, RORY  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Alzheimer's Disease;Area;Attention deficit hyperactivity disorder;Behavior;Behavioral;Brain;Brain Diseases;Categories;Cognition;cognitive function;cognitive process;Color;Complex;Decision Making;Dimensions;Disease;Disparate;dorsal visual stream;Educational process of instructing;Electrophysiology (science);experimental study;Feedback;flexibility;Goals;Grouping;insight;Knowledge;Lateral;lateral intraparietal area;Learning;Mediating;Monitor;Monkeys;Motion;Nervous System Disorder;neural;neuromechanism;Neurons;nonhuman primate;novel;object recognition;Outcome;Output;Parkinson Disease;Pattern;Performance;Play;Population;Prefrontal Cortex;Primates;Process;Research;Role;Sensory;sensory input;sensory stimulus;Shapes;Stimulus;Structure;superior colliculus Corpora quadrigemina;System;targeted treatment;Task Performances;Testing;theories;Training;ventral visual stream;Visual;visual information;visual map;visual processing;visual stimulus;Work

PROJECT_TITLE: How do cortical hierarchies mediate visual categorization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE The proposed research is geared towards discovering novel druggable sites on a physiologically important ion channel to treat neurological conditions such as infantile epileptic encephalopathy, which is a severe form of early-onset epilepsy. We will apply novel and established techniques and approaches towards determining the binding sites and the mechanisms of action of known allosteric inhibitors and activators, which will help us understand how these molecules affect these channels. The insight we gain into the basic mechanism of this important class of channels will also enable the design and discovery of novel therapeutics that specifically target the channels responsible for these disease conditions.

PI_NAMEs: NIMIGEAN, CRINA M (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Ablation;Affect;Allosteric Site;Binding;Binding Sites;Bioinformatics;Biological Assay;Cells;Cellular Membrane;Child;Complex;conformer;Conserved Sequence;Coupling;Cryoelectron Microscopy;Cyclic AMP;Cyclic Nucleotides;cyclic-nucleotide gated ion channels;density;design;Development;Disease;Drug Binding Site;Drug Design;drug development;Drug usage;early onset;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Family member;FDA approved;Generations;Genetic Polymorphism;Genomics;Goals;HCN1 channel;HCN1 gene;Impairment;infancy;Inherited;inhibitor;insight;Investigation;Ion Channel;Ion Channel Gating;Ligands;Lipid Binding;Lipids;Liposomes;Maps;Membrane;Missense Mutation;Modeling;Molecular;Molecular Conformation;Mutagenesis;mutant;Mutate;Mutation;Nervous System;Neurologic;neuronal excitability;novel;novel drug class;novel therapeutics;Oocytes;Pain;pain inhibition;painful neuropathy;particle;Pathogenicity;Pathology;Pathway interactions;Patients;Periodicity;personalized medicine;Pharmaceutical Preparations;Pharmacologic Substance;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Physiological;Play;Positioning Attribute;positive allosteric modulator;Property;Propofol;Protein Engineering;Protein Isoforms;rational design;reconstitution;Research;Resolution;response;Role;Sampling;sensor;Severities;side effect;Site;small molecule;Specificity;Structure;Structure-Activity Relationship;Techniques;Testing;Therapeutic;therapeutic candidate;tool;trafficking;Validation;Vesicle;voltage

PROJECT_TITLE: Uncovering druggable allosteric sites in HCN channels

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Genetics are known to play a strong role in the development of inflammatory bowel diseases but exactly how genetic variants contribute to disease pathways is not well understood. Genetic variants can be associated with regulating molecular mechanisms such as chromatin accessibility and gene expression by mapping molecular quantitative trait loci (QTL). Using colocalization, we can link QTL to disease-associated variants to identify putative causal mechanisms of genetic variants that can provide novel insight into disease mechanisms as well as serve as potential therapeutic targets or clinical markers by identifying target genes contributing to disease.

PI_NAMEs: NISHIYAMA, NINA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Alleles;ATAC-seq;Binding;Bioinformatics;Biological Assay;calmodulin-dependent protein kinase II;Candidate Disease Gene;career;causal variant;cell type;Chromatin;Chromatin Structure;Chronic;Clinical;Clinical Markers;Code;collaborative environment;Colon;Colonic Diseases;Computational Biology;computing resources;Crohn's disease;Data;Development;Disease;disease heterogeneity;Disease Pathway;disease phenotype;disorder risk;Doctor of Philosophy;Elements;Enhancers;Environmental Risk Factor;Epithelial Cells;experience;falls;Freezing;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Genes;Genetic;genetic variant;Genetic Variation;genome wide association study;genomic data;genomic locus;Genotype;Genotype-Tissue Expression Project;gut inflammation;gut microbiota;Immune;Immune response;improved;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;intestinal epithelium;Knowledge;Link;Luciferases;Maps;Mentorship;Molecular;monolayer;Mucous Membrane;North Carolina;novel;novel marker;Pathogenesis;Pathway interactions;Patients;Permeability;Physiological;Play;Predisposition;Promoter Regions;Publishing;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Research;Research Personnel;risk variant;Role;Sampling;therapeutic candidate;therapeutic target;Tight Junctions;Tissues;Training;trait;transcription factor;Ulcerative Colitis;Universities;Untranslated RNA;Variant

PROJECT_TITLE: Using molecular quantitative trait loci mapping approaches to determine candidate gene regulatory mechanisms of functional variants within inflammatory bowel disease GWAS loci.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

ORG_STATE: MA

PHR: PROJECT NARRATIVE Mammalian SWI/SNF (mSWI/SNF or BAF) complexes are multi-subunit ATP-dependent chromatin remodeling complexes that play critical roles in establishing and maintaining DNA accessibility and gene expression. In this work, I will define the contribution of sequence-non-specific DNA binding domains, a known structured feature of mSWI/SNF complexes, to complex assembly and integrity, nucleosome remodeling and ATPase activities, and genome-wide chromatin targeting and DNA accessibility in a human cellular context. This work will further our mechanistic understanding of mSWI/SNF biology and elucidate its role in the regulation of gene expression in normal and disease states.

PI_NAMEs: LIEBERMAN, WHITNEY KATE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Architecture;ARID Domain;ARID1A gene;ATAC-seq;ATP phosphohydrolase;Biochemical;Biological Assay;Biological Models;Biology;Cancer cell line;Cell Physiology;Cells;Chromatin;Chromatin Remodeling Factor;Cleavage Under Targets and Release Using Nuclease;Combinatorics;Complex;Deficiency Diseases;defined contribution;Disease;DNA;DNA Binding;DNA Binding Domain;experimental study;Family;Fellowship;Foundations;Gene Expression;Gene Expression Regulation;gene product;Generations;Genes;genome-wide;Genomics;High Mobility Group Proteins;Histones;Human;Human Cell Line;human disease;Immunoprecipitation;In Vitro;Incubated;Investigation;knock-down;Knock-out;Length;Link;Maintenance;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;mutant;Mutate;Mutation;Neurodevelopmental Disorder;novel therapeutics;Nucleosomes;Pathway interactions;Play;Process;programs;protein complex;rare cancer;Reader;Recurrent disease;Research;restriction enzyme;Role;SMARCB1 gene;SMARCE1 gene;stoichiometry;Structure;Sucrose;Surface;SWI/SNF Family Complex;Variant;Western Blotting;Winged Helix;Work

PROJECT_TITLE: Defining the roles for the sequence-non-specific DNA-binding domains in mammalian SWI/SNF chromatin remodeling complex assembly and function


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: BLOOMINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  Disrupted interoception (i.e., detection, integration, and interpretation of internal body states) may be a critical process in distressing psychosis symptoms (i.e., hallucinations and delusion). Manipulation of internal body states during predictive coding experiments is necessary to move beyond descriptive research, overcome limitations of existing tasks, and elucidate how interoceptive perception is related to key clinical features in the psychosis-spectrum. Using an individual differences design, computational modeling will dissect interoceptive predictive coding into subprocesses and disentangle their relationships with psychosis symptoms versus cognition to provide translational insights that may inform future treatment targets.

PI_NAMEs: HERMS, EMMA  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TITLE: Computational Modeling of Interoceptive Perception across the Psychosis-Spectrum

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Stroke;Traumatic Head and Spine Injury

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Closed-loop VNS was recently approved by the FDA to restore upper limb mobility for patients with stroke, but the mechanism is poorly defined. This work will explore the hypothesis that closed-loop VNS gates plasticity through disinhibition by phasic cholinergic signaling.

PI_NAMEs: WELLE, CRISTIN G (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acceleration;Acetylcholine;addiction;Area;basal forebrain;behavioral outcome;Brain;cholinergic;Clinical Research;Data;Dendritic Spines;Disinhibition;Elements;Etiology;excitatory neuron;FDA approved;Future;Goals;improved;Infarction;injury recovery;Interneurons;Intervention;Learning;Mediating;Modeling;Motor;Motor Cortex;motor learning;motor recovery;Nervous System Trauma;neural;Neurologic;Outcome;patient mobility;Phase;Play;Population;post stroke;Post-Traumatic Stress Disorders;pre-clinical;prevent;Protocols documentation;Recovery;Recovery of Function;Rehabilitation therapy;Rodent;Role;Signal Transduction;skills;Spinal cord injury;Stroke;stroke recovery;Synaptic plasticity;Therapeutic;Time;Traumatic Brain Injury;Upper Extremity;vagus nerve stimulation;Work

PROJECT_TITLE: Vagus nerve stimulation drives plasticity through inhibitory interneurons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Avoiding immune destruction is a hallmark of cancer that is especially prominent within pancreatic cancer tumors (10,11). The proposed studies will investigate of a population of highly functional regulatory T cells to determine their mechanisms of immune suppression and their impact in pancreatic cancer. The data generated from these studies will have implications in the study of autoimmune disease and other types of cancer, providing critical information for not only the development of these diseases but also in the design of new therapeutics.

PI_NAMEs: DROUILLARD, DONOVAN G (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;anti-tumor immune response;Autoimmune Diseases;Biological Assay;cancer cell;cancer type;career;CCL20 gene;CCR;CCR6 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aggregation;Cell Physiology;Cells;Cellular biology;checkpoint therapy;chemokine;chemokine receptor;Chemotaxis;cytokine;Cytoprotection;Data;Dendritic Cells;design;Development;Disease;Disease Progression;effector T cell;Enzyme-Linked Immunosorbent Assay;Equilibrium;Fellowship;Fibroblasts;Flow Cytometry;Genetic Transcription;Goals;human disease;immune checkpoint;Immune checkpoint inhibitor;Immune mediated destruction;Immunosuppression;Immunotherapy;In Vitro;in vitro Assay;in vivo Model;infiltrating duct carcinoma;Infiltration;innovation;insight;Interruption;Learning;Lesion;Life Expectancy;Ligands;Macrophage;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mediator;Methods;mouse model;Myelogenous;nanomolar;novel;novel therapeutics;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pharmacologic;Phenotype;Physicians;polarized cell;Population;Pre-Clinical Model;premalignant;prevent;Prognosis;Property;Proteins;receptor;receptor function;recruit;Regulatory T-Lymphocyte;Reporting;Resistance;response;Role;Scientist;Shapes;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Solid;Surface;T memory cell;T-Cell Depletion;T-Lymphocyte;T-Lymphocyte Subsets;Testing;trafficking;Transgenic Mice;tumor;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenic;Work

PROJECT_TITLE: The role of CCR6 in Pancreatic Cancer and Tregs

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE To make high-potency antibodies that both help control infections cause allergies and autoimmune diseases, B cells go through a process of Darwinian-like evolution in which those that make the most potent antibodies are preferentially selected to become antibody producers. Work in this proposal is aimed at clarifying certain key points of this evolutionary process that are not completely understood. Clarifying these points may help us induce more potent antibodies against pathogens such as influenza, HIV, and SARS-CoV2 by vaccination.

PI_NAMEs: VICTORA, GABRIEL D (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;Affinity;Amino Acid Substitution;Antibodies;Antibody-mediated protection;antigen binding;Antigens;Autoimmune Diseases;B-Cell Antigen Receptor;B-Lymphocytes;Basic Science;Biological;Cell Lineage;Cells;Chickens;Clone Cells;Communicable Diseases;Complex;computer framework;Coupling;COVID-19 vaccination;DNA;Elements;Enzyme Activation;Epitopes;Evolution;experimental study;Feedback;fitness;Goals;Hand;HIV;Hypersensitivity;IgY;Immunoglobulin Genes;Immunoglobulin Somatic Hypermutation;Immunoglobulins;improved;in vivo;Individual;Infection Control;Influenza;Influenza Hemagglutinin;insight;Knowledge;Laboratories;Lesion;Measures;Methodology;Methods;Modeling;Modification;Molecular;Mus;Mutation;mutation screening;OLFM4 gene;Outcome;outcome prediction;Output;pathogen;Pathway interactions;Pattern;permissiveness;Play;Population;Positioning Attribute;Process;Property;Proteins;Reaction;repaired;Reproducibility;Shapes;Site;Somatic Mutation;Structure of germinal center of lymph node;System;Techniques;Time;tool;Vaccination;Work;Yeasts

PROJECT_TITLE: Inferring the rules of antibody evolution using replicated germinal centers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-U (02)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Natural Products

ORG_DEPT: CHEMISTRY

PHR: PROJECT NARRATIVE Nonribosomal peptides are an important class of natural products which display great structural and functional diversity, and many possess important bioactivity. This project proposes to elucidate the structure and biosynthesis of several nonribosomal peptides containing α,β-dehydroamino acids produced by a unique C domain, the CmodAA domain. Discovering novel nonribosomal peptides and expounding their biosynthesis will provide a base of knowledge that can lead to the discovery of other α,β-dehydroamino acid containing natural products and expand our current library of bioactive therapeutic peptides.

PI_NAMEs: MULL, RYAN WYATT (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acids;adenylate;Amides;Amino Acids;Anabolism;Anti-viral Agents;anticancer activity;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;Antineoplastic Agents;Bacteria;base;beta-Lactams;bioactive natural products;Bioinformatics;Biological;Biological Assay;Bleomycin;Chemical Structure;Chemicals;Cloning;comparative;Complex;Cre lox recombination system;Dehydration;design;Development;Enterococcus faecium;Enzymes;Exhibits;Family;Gene Cluster;genetic manipulation;Genome;Goals;in silico;In Vitro;in vivo;insight;Knowledge;Libraries;Mass Spectrum Analysis;metabolomics;microcystin;microorganism;Minimum Inhibitory Concentration measurement;Mining;natural product derivative;Natural Products;novel;novel therapeutics;Pathway interactions;Peptide Biosynthesis;peptide drug;peptide structure;peptide synthase;Peptides;Physical condensation;Plasmids;Play;Production;reconstitution;Research;Resistance;Role;Soil;Source;stem;Streptomyces;Structure;Tandem Repeat Sequences;Therapeutic;therapeutic development;Toxin;Valine;Work

PROJECT_TITLE: Identification and Biosynthesis of Dehydrated Nonribosomal Peptides from Streptomyces

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The aim of this research is to develop multimodal delineation algorithms capable of accurately and reproducibly delineating radiation therapy gross target volumes and clinical target volumes in a variety of head and neck cancer locations, as well as target volumes specific to recurrent disease scenarios. Our approach will use deep learning and multimodal PET/CT imaging, while capturing inter- and intra- observer variability.

PI_NAMEs: EL FAKHRI, GEORGES  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Accounting;Agreement;Algorithms;Anatomy;cancer site;chemotherapy;Classification;Clinical;clinical predictors;clinical risk;cohort;common treatment;Consensus;Consumption;contrast enhanced computed tomography;Data;deep learning;deep learning algorithm;deep neural network;Diffusion;Disease;Dose;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Guidelines;Head and Neck Cancer;head and neck cancer patient;high risk;Histology;Human Papillomavirus;Image;improved;Intraobserver Variability;irradiation;Label;Learning;learning network;Malignant neoplasm of larynx;Malignant neoplasm of nasopharynx;malignant oropharynx neoplasm;Maps;multimodality;neglect;Nodal;nonbinary;novel;Operative Surgical Procedures;Organ;Pathway interactions;Patient imaging;Patients;Pattern;Performance;PET/CT scan;Physicians;Primary Neoplasm;Prognosis;Radiation therapy;Recurrence;Recurrent disease;Reproducibility;Research;Risk;risk prediction;Site;standard of care;Techniques;Time;Training;treatment planning;treatment strategy;tumor;Tumor Volume;Validation;virtual clinical trial;Weight;X-Ray Computed Tomography

PROJECT_TITLE: Deep learning-based target volume delineation capturing observer variability in head and neck cancer

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: -Project Narrative- Dendritic anomalies are a prominent clinical feature across neurodevelopmental disorders, indicating that impeding dendrite development can have long-lasting consequences on neuron and circuit function. This project seeks to elucidate the mechanisms that guide dendritic development, which is critical to understanding disease pathology and informing early treatment strategies. Specifically, a portion of the proposed research investigates potential dysfunction in dendritic development caused by mutation of a gene called FRMD7 that is responsible for most cases of idiopathic congenital nystagmus in humans.

PI_NAMEs: PITCHER, MIAH NIEVA (contact)

PROJECT_TERMS: Adult;Behavior;Biological Assay;Biological Models;Calcium;Cell Physiology;Cells;Cellular Morphology;Clinical;clinically relevant;Congenital Nystagmus;Coupled;Cues;Dendrites;detector;Development;Disease;Distal;Early treatment;Elements;Exhibits;experimental study;Eye;Functional disorder;Genes;Genetic;Glutamate Receptor;Glutamates;Human;Image;Impairment;insight;Interneurons;Knowledge;Label;Light;Location;Maps;Measures;Mediating;Modeling;Molecular;Morphology;Motion;mouse model;Mus;Mutation;Nervous System Physiology;Neurodevelopmental Disorder;neuronal cell body;Neurons;neurotransmitter release;Neurotransmitters;Output;Pathologic Nystagmus;Pathology;Patients;Pattern;Phenotype;postsynaptic;preference;Property;protein transport;Proteins;Radial;receptor;Reflex action;Reporter;Research;research study;response;Retina;Shapes;Signal Transduction;starburst amacrine cell;Stimulus;Structure;Synapses;Tertiary Protein Structure;Testing;Time;timeline;trafficking;treatment strategy;two-photon;Varicosity;visual stimulus;visual tracking;Work

PROJECT_TITLE: Investigating Mechanisms of Development in Retinal Direction Selective Circuits

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PI_NAMEs: SHAREEF, AFZAAL  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Ablation;Alternative Splicing;Amino Acids;Binding;Bioinformatics;Biological;Biological Assay;Biological Process;Chimeric Proteins;Chromatin;clinically relevant;Co-Immunoprecipitations;Complementary DNA;Custom;Data;Data Set;Databases;Disease;Distant;DNA Damage;DNA Repair;DNA strand break;Elements;endonuclease;Event;experience;Future;Gene Expression;Generations;Genes;genetic approach;genetic element;Genome;Genomic DNA;Genomic Instability;Histones;Human;Human Genome;In Vitro;intermolecular interaction;Introns;Knowledge;Long Interspersed Elements;mammalian genome;Mediating;Messenger RNA;mouse genome;Mus;nonhuman primate;novel;Organ;Output;overexpression;Plasmids;Point Mutation;Process;programs;Protein Isoforms;protein structure;Proteins;Publishing;Pythons;Repetitive Sequence;Reporting;Resources;Retrotransposition;Retrotransposon;Reverse Transcription;RNA Binding;RNA Splicing;RNA-Directed DNA Polymerase;Rodent;Role;seal;sex;Single-Stranded DNA;Site;Structure;Testing;tool;Transcript;transcriptome;transcriptome sequencing;Variant

PROJECT_TITLE: Deciphering functions of the LINE-1 ORF2p protein

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F08-L (20)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Prevention;Sleep Research

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE Circadian disturbance is a well know hazard of shift work and has been linked to the development of long-term negative health outcomes such as cardiovascular and cardiometabolic diseases. While this link is known, there are not quantitative frameworks for measuring disturbance of central and peripheral body clocks in humans in real-world settings. This proposal seeks to further our knowledge of circadian rhythms in the real-world using wearable sensors, advance our technologies for quantitating synchrony of central and peripheral body clocks, and translate this information into actionable models to help shift workers maintain synchrony.

PI_NAMEs: WEED, LARA  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Algorithms;Ambulatory Monitoring;Behavior;Behavioral;Biological;Biological Clocks;Biological Rhythm;biological systems;Biomechanics;Biomedical Engineering;Breathing;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;career;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical assessments;Collaborations;collaborative environment;Communication;Complex;Coupled;Data;Development;Diet;Disease;Doctor of Philosophy;empowerment;Engineering;Environment;Equilibrium;Evaluation;Exposure to;Future;Goals;hazard;Health;Healthcare;Heart Rate;Homeostasis;Human;Hypothalamic structure;Impairment;improved;in silico;Intervention;Knowledge;Laboratories;Leadership;Light;Link;Longevity;Machine Learning;Maintenance;Malignant Neoplasms;Measurement;Measures;Melatonin;Mentors;Metabolic Diseases;Methods;Modeling;novel;Outcome;Pattern;Periodicity;Peripheral;Persons;Phase;Physiologic Monitoring;Physiological;prediction algorithm;Process;programs;Recovery;Research Personnel;Resources;response;Risk Reduction;Rotation;Schedule;shift work;signal processing;Signal Transduction;skills;Stimulus;suprachiasmatic nucleus;System;Technology;Testing;theories;Time;tool;Training;Translating;Translations;Universities;Variant;wearable data;wearable sensor technology;Work

PROJECT_TITLE: A quantitative framework for measuring the coordination of central and peripheral body clocks in humans in the real world

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE SCN8A encephalopathy is a severe epilepsy syndrome caused by gain-of-function mutations in the sodium channel Nav1.6. It is unknown how these mutations affect the physiology of parvalbumin-positive (PV) inhibitory interneurons, a critical inhibitory interneuron subtype that expresses Nav1.6. By electrophysiologically recording neurons from two patient-derived mouse models of SCN8A encephalopathy, this proposal aims to clarify the contributions of PV interneurons to SCN8A encephalopathy and better understand if these interneurons may provide a novel therapeutic target.

PI_NAMEs: MIRALLES, RAQUEL  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Action Potentials;Affect;Age;Age Months;Axon;Cells;Data;Disease;Down-Regulation;dravet syndrome;Electroencephalography;Electrophysiology (science);Epilepsy;epileptic encephalopathies;excitatory neuron;Exhibits;experience;Failure;Fire - disasters;Frequencies;Functional disorder;gain of function;gain of function mutation;Generations;Genetic;Germ Lines;Human;Impact Seizures;Impaired cognition;in vivo;inhibitory neuron;Interneuron function;Interneurons;Kinetics;knock-down;Knock-in;Link;Modeling;Monitor;mouse model;Mus;mutant;Mutation;neuronal cell body;Neuronal Dysfunction;Neurons;new therapeutic target;novel therapeutic intervention;Parvalbumins;patch clamp;Patients;Phenotype;Physiology;Play;Predisposition;Pyramidal Cells;Refractory;Risk;RNA;Role;SCN1A protein;SCN8A encephalopathy;SCN8A gene;Seizures;selective expression;Sodium;Sodium Channel;Somatosensory Cortex;Somatostatin;sudden unexpected death in epilepsy;Synapses;Synaptic Transmission;Syndrome;Techniques;Temporal Lobe Epilepsy;Testing;Therapeutic;Training;voltage;Work

PROJECT_TITLE: Aberrant Parvalbumin-Positive Interneuron Activity in SCN8A Epileptic Encephalopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Defects in mitochondria morphology negatively affect cellular health and are observed in a wide range of diseases such as in Parkinson’s disease and fatty liver disease. Understanding how mitochondria regulate their morphology is a critical component in recognizing causes of mitochondria dysfunction within those diseases. This proposal aims to explore a new pathway for regulating mitochondria morphology through sensing defects in mitochondria proteostasis.

PI_NAMEs: YEUNG, NELSON  (contact)

PROJECT_TERMS: Affect;Biological Assay;Biotin;Biotinylation;Categories;Cells;Censuses;chaperonin;Complex;Cytoplasm;Defect;Disease;Drug Targeting;Electron Transport;Escherichia coli;experimental study;fatty liver disease;Gel;Genes;Genus Hippocampus;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Heart failure;Heat shock proteins;Homologous Gene;Homologous Protein;Human;Image;Inner mitochondrial membrane;interest;knock-down;Knowledge;Label;Length;Ligase;Mass Spectrum Analysis;member;Membrane;Metabolic Diseases;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Matrix;Mitochondrial Proteins;Molecular;Molecular Chaperones;Morphology;Neurodegenerative Disorders;Optic atrophy 1;Outer Mitochondrial Membrane;overexpression;Parkin;Parkinson Disease;Pathway interactions;Production;Protein Family;protein folding;Protein Import;Protein Isoforms;Proteins;proteostasis;Regulation;Research;RNA Interference;Role;Running;Series;Set protein;Signal Transduction;Silver Staining;Small Interfering RNA;stem;Streptavidin;Testing;Translating;translocase;Visualization

PROJECT_TITLE: Investigating the Role of HSPE1 in Regulating OPA1

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Glioblastoma ranks among the deadliest of all human cancers, with no effective treatment. I will study roles of a tRNA modification enzyme in maintaining stemness and promoting growth of cancer stem cells in glioblastoma. This study will inspire the design of potential new treatments for patients afflicted with glioblastoma.

PI_NAMEs: DUAN, TINGTING  (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Adenine;Adult;Affect;aggressive therapy;Amino Acids;angiogenesis;Area;Base Pairing;Biological Assay;Brain Neoplasms;cancer stem cell;Cell Maintenance;cell type;Chromatography;clinical care;Codon Nucleotides;cofactor;Cues;Data;Data Set;Dependence;Deposition;design;Development;dietary restriction;differential expression;Disease;effective therapy;Enzymes;Epigenetic Process;epitranscriptomics;experimental study;Failure;Genetic Code;Genetic study;Genetic Transcription;Glioblastoma;Growth;Homeostasis;Human;Immune;improved;In Vitro;in vivo;Individual;Initiator Codon;insight;knock-down;life span;Link;Liquid substance;Maintenance;Malignant neoplasm of brain;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Messenger RNA;Metabolic Control;Metabolism;model organism;Modification;Molecular;molecular targeted therapies;mRNA Translation;Mus;mutant;neoplastic cell;nerve stem cell;novel therapeutics;Oncogenic;Operative Surgical Procedures;palliation;Patient Care;Patients;Peptide Initiation Factors;Peptides;Phenotype;Population;posttranscriptional;Process;Prognosis;programs;Proliferating;Protein Biosynthesis;Proteomics;Publishing;Recurrence;Regulation;ribosome profiling;Role;Sampling;self renewing cell;self-renewal;Signal Transduction;standard of care;stem;stem cell growth;stem cell proliferation;stem cells;stem-like cell;stemness;Structure;tandem mass spectrometry;Testing;Threonine;Transfer RNA;Translational Regulation;Translations;tumor;tumor growth;tumor heterogeneity;tumor xenograft;tumorigenesis

PROJECT_TITLE: Metabolic control of tRNA-mediated translational reprogramming in glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09A-R (20)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative  Alcohol misuse (e.g., binge and high-intensity drinking) adversely affects psychosocial well-being across development. While social influences (i.e., the quality, frequency, and specific nature of social interactions and social relationships) can protect against alcohol misuse, they can also exacerbate risk. Research investigating both longitudinal and proximal social influences on alcohol use is required to identify precise intervention targets.

PI_NAMEs: VOLPE, LAILA  (contact)

PROGRAM_OFFICER_NAME: ZHA, WENXING

PROJECT_TERMS: Acceleration;Adolescence;Adolescent;Adult;Affect;Age;Alcohol abuse;alcohol availability;Alcohol consumption;alcohol measurement;alcohol misuse;alcohol related consequences;alcohol risk;alcohol use disorder;Alcoholic Intoxication;Alcohols;Award;binge drinking;career;Cellular Phone;Clinical;cohort;cost;Data;Data Analyses;Data Set;density;Dependence;design;Development;diverse data;drinking;Eating;Ecological momentary assessment;emerging adult;Emotional;Ensure;Event;Expectancy;experience;Family;Fostering;Frequencies;Friends;Future;Government;Growth;Health;Heavy Drinking;high intensity drinking;high risk;Home;Individual;Injury;Intervention;Interview;Investigation;Life;Light;Link;longitudinal dataset;Manuscripts;Measures;Methodology;Mission;multilevel analysis;National Institute on Alcohol Abuse and Alcoholism;National Longitudinal Survey of Adolescent to Adult Health;National Research Service Awards;Nature;Outcome;Parents;Participant;Pathway Analysis;Pattern;peer;Peer Group;Perception;Persons;Prevention;Process;protective factors;Psychopathology;psychosocial wellbeing;Public Health;Questionnaires;recruit;reduced alcohol use;Reporting;Research;Research Support;Risk;Schools;Scientist;Signal Transduction;skills;social;Social Environment;social influence;Social Interaction;Social Network;social relationships;Social support;Students;Surveys;Techniques;Time;Training;underage drinking;Variant;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Using Advanced Methodologies to Investigate the Effect of Social Influences on Alcohol Use Across Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Project Narrative Mycobacterium tuberculosis infects a quarter of the global population and the prevalence of multidrug resistant strains of Mycobacterium tuberculosis is on the rise. Understanding Mycobacterium tuberculosis physiology and identifying the pathways involved in antibiotic resistance are key to developing novel anti-tuberculosis drugs. This research is relevant to the NIAID mission to support basic research that advances our understanding, treatment, and prevention of infectious diseases.

PI_NAMEs: SAKARIN, ISABEL JANTANA (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Address;Affect;Anabolism;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;Antibiotics;arabinogalactan;Bacterial Infections;Basic Science;Biochemical;Biogenesis;Biological Models;Biological Process;Biology;Carbohydrates;cell envelope;Cell Membrane Permeability;Cell model;Cells;combat;Communicable Diseases;Data;Deposition;Detection;Disease;Drug Combinations;Drug resistance;Drug Targeting;Enzymes;fighting;fluidity;Fluorescent Probes;Gene Modified;Genetic;genomic locus;Genus Mycobacterium;Goals;Hydrolase;Hydrophobicity;Immune response;In Vitro;inhibitor;Knowledge;Lipids;Membrane;Membrane Fluidity;Mission;Morphology;Multi-Drug Resistance;mutant;mycobacterial;Mycobacterium tuberculosis;Mycolic Acid;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;Pathway interactions;Permeability;Phenotype;Physiology;Population;Predisposition;Prevalence;Prevention;Production;Property;Protein Biosynthesis;protein purification;Proteins;rational design;Research;Resistance;resistant strain;Review Literature;Role;solute;Structure;Testing;Therapeutic;Tuberculosis;tuberculosis drugs

PROJECT_TITLE: Rv3802c function in mycobacterial cell envelope remodeling, barrier properties, and antibiotic susceptibility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Monoaminergic systems in the brain play critical roles in the regulation of a wide variety of neural processes, and are heavily implicated in the etiology of numerous mood-related disorders in humans, including major depressive disorder (MDD). While mood disorders are highly heritable, it is clear that environmental factors also contribute significantly to disease, with chronic stress representing one of the most common precipitating factors for mood-related diagnoses; however, little remains known concerning the precise molecular mechanisms mediating mood disorder/stress vulnerability or individual responsiveness to antidepressants. This proposal thus aims to comprehensively examine a novel molecular mechanism recently implicated in stress vulnerability and MDD – i.e., histone H3 monoaminylation in brain, a protein modification discovered and characterized by our laboratory – with respect to its contributions to cell-type specific transcriptional plasticity and its roles in the mediation of stress susceptibility and/or antidepressant efficacy.

PI_NAMEs: MAZE, IAN S. (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Adult;Affect;Animals;anti-depressive agents;Astrocytes;Attenuated;Autopsy;Behavior;Behavioral;behavioral plasticity;Binding;Biochemical;Biophysics;Brain;cell type;Cells;Central Nervous System;Chemicals;Chromatin;Chromatin Structure;Chronic;Chronic stress;Cognitive;Complex;Coupled;Data;Diagnosis;Disease;Dopamine;early life stress;Environmental Risk Factor;Enzymes;epigenomics;Etiology;Exposure to;Female;Fluoxetine;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profiling;genetic manipulation;Genetic Transcription;genome-wide;Glutamine;Heritability;Histamine;Histone H3;Histones;Human;In Vitro;in vivo;Individual;Ketamine;Label;Laboratories;Link;Major Depressive Disorder;male;Medial;Mediating;Mediation;Mental disorders;Methodology;Microglia;Modeling;Molecular;monoamine;Mood Disorders;Moods;Mus;neural;Neuroglia;Neuronal Dysfunction;Neurons;neurotransmission;novel;NRH - quinone oxidoreductase2;Nucleosomes;Oligodendroglia;Onset of illness;Output;Oxidoreductase;oxysterol binding protein;permissiveness;pharmacologic;Physiological;Play;Post-Translational Protein Processing;pre-clinical;Precipitating Factors;Predisposition;Prefrontal Cortex;Process;programs;Proteins;Public Health;Quinone Reductases;Reader;recruit;Regulation;Resources;response;Rewards;Rodent Model;Role;Selective Serotonin Reuptake Inhibitor;Serotonin;Signal Transduction;Stress;stress related disorder;Structure;Study models;Substance Use Disorder;Syndrome;System;therapy outcome;Transcriptional Regulation;transglutaminase 2;Validation;Writing

PROJECT_TITLE: Molecular studies of neural histone monoaminylation in normal and aberrant brain plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases;West Nile Virus

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: RESEARCH NARRATIVE Flaviviruses are a large family of RNA viruses that are significant global pathogens, infecting up to 400 million people a year. The flavivirus protease is an essential non-structural protein that is an attractive target for antiviral therapeutics; however, the intracellular molecular determinants for flavivirus protease cleavage of substrates and how these factors affect viral fitness is unknown. The purpose of the proposed study is to understand the proteolytic determinants of flavivirus infection to uncover potential pathways that can be exploited in the development of antiviral therapies targeting this viral protein.

PI_NAMEs: CORLISS, LOCHLAIN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Address;Affect;Amino Acids;Anti-viral Agents;antiviral drug development;arthropod-borne;Capsid;Cells;Clinical;cofactor;Complex;Cytoplasm;Data;Dengue Virus;Development;Disease;Encephalitis;Endoplasmic Reticulum;Event;experimental study;Family;Fetus;Flavivirus;Flavivirus Infections;Genetic;Genome;Goals;helicase;Individual;Infection;interest;Intervention;Kinetics;Knowledge;Laboratories;Life Cycle Stages;live cell imaging;live cell microscopy;Mediating;Membrane;Microcephaly;Molecular;Mutation;Nonstructural Protein;Organelles;pathogen;Pathway interactions;Peptide Hydrolases;Peptides;Persons;Pharmaceutical Preparations;Play;Polyproteins;Process;Productivity;Protease Domain;protein complex;Proteins;Public Health;Publishing;recombinant virus;Recovery;Reporter;Reporting;RNA;RNA Viruses;Role;Serine Protease;Shock;Site;Specificity;Structural Protein;Structure;Substrate Specificity;System;targeted treatment;Testing;therapeutic target;Therapeutic Uses;therapeutically effective;tool;Translating;Translation Process;Viral;viral fitness;Viral Hemorrhagic Fevers;Viral Nonstructural Proteins;Viral Physiology;Viral Proteins;Virus;Virus Diseases;West Nile virus;Work;Yellow fever virus;Zika Virus

PROJECT_TITLE: Elucidating the Proteolytic Determinants of Flavivirus Infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-Y (20)]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE Differential RNA-sequencing of temporal cortex autopsy samples from typical and atypical forms of the neurodevelopmental disorder Rett syndrome (RTT) has uncovered elevated heat shock signaling as a highly conserved aspect of the disease. Here we describe a strategy to delineate whether inhibition of HS signaling is therapeutic through genetic and pharmacological manipulation of the HS response in mouse models of RTT and determine the underlying mechanisms driving cellular stress responses. We posit that our findings may uncover novel mechanisms for RTT pathogenesis which will aid in drug-discovery efforts for the disorder.

PI_NAMEs: GONZALEZ, SONIA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Acute;Address;Adverse effects;Affect;autism spectrum disorder;Automobile Driving;Autopsy;Behavioral;Bioinformatics;biological adaptation to stress;Brain region;Breeding;career;career development;Cellular Stress;Cessation of life;Chromatin;Chromatin Structure;Clinical;clinical diagnosis;clinical efficacy;cohort;Complement;Conceptions;Coupling;Data;design;differential expression;Disease;Disease Progression;Disinhibition;DNA Methylation;DNA Polymerase II;DNA Repair;drug discovery;Exhibits;experimental study;Fetal Alcohol Spectrum Disorder;flavopiridol;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Goals;Harvest;Health;Heat shock proteins;heat-shock factor 1;Heat-Shock Response;hyperthermia treatment;Impairment;in vivo;Induced Hyperthermia;Inflammation;inhibitor;Kinetics;Knockout Mice;Knowledge;loss of function mutation;Mediating;Mentors;Methyl-CpG-Binding Protein 2;Missense Mutation;Modeling;Molecular;Morphologic artifacts;mouse model;Movement;Mus;Mutant Strains Mice;Mutation;Neurodevelopmental Disorder;Neuropharmacology;Neurosciences;Noise;novel;Outcome Measure;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway Analysis;Pathway interactions;patient population;Patients;pharmacologic;Phenotype;Population;Precision Run-On Sequencing;Process;promoter;Proteins;Reader;Regulator Genes;Research;response;Rett Syndrome;Role;Running;Sampling;Seizures;Signal Transduction;social;Symptoms;Syndrome;Temporal Lobe;Testing;theories;Therapeutic;Time;Training;transcription factor;Transcription Initiation;Transcription Initiation Site;Transcription Repressor;transcriptome sequencing

PROJECT_TITLE: The interplay of the heat shock cascade and Rett syndrome


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Nutrition

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE While rates of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH) continue to rise worldwide, the mechanisms that govern fatty liver disease onset and progression remain poorly understood. We have shown that loss of the mitophagy receptor BNIP3 leads to spontaneous lipid accumulation in healthy liver, and contributes to NAFLD and NASH severity in mice and to hepatocellular carcinoma in humans. Here, I propose to elucidate the mechanism by which BNIP3 works to clear lipid from the liver, with the goal of contributing to the development of novel therapeutic options for NAFLD and NASH.

PI_NAMEs: BOCK-HUGHES, ALTHEA  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Ablation;Accounting;Adult;Affect;analysis pipeline;Automobile Driving;Autophagocytosis;Cell Physiology;Cells;Central Vein;Characteristics;Cirrhosis;Data;Dependovirus;Development;Disease;Disease Progression;Exhibits;Fasting;Fatty Liver;fatty liver disease;Fluorescence-Activated Cell Sorting;Future;Gene Expression;Gene Expression Profile;Genetic;Genetically Engineered Mouse;Goals;Hepatic;hepatocellular carcinoma cell line;Hepatocyte;HepG2;Homeostasis;Hour;Human;Image Analysis;In Vitro;in vivo;insight;knock-down;Link;lipid metabolism;Lipids;Liver;Liver diseases;Liver parenchyma;liver transplantation;Lysosomes;Machine Learning;Mediating;Mediator;Membrane;Metabolic;Mitochondria;mitochondrial autophagy;Molecular;Morphology;Mus;new therapeutic target;non-alcoholic fatty liver;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel strategies;novel therapeutics;Nutrient;nutrient deprivation;obese patients;Obesity;Onset of illness;Output;overexpression;Pathway interactions;Pattern;Population;Portal vein structure;prevent;Primary carcinoma of the liver cells;Process;Proteins;receptor;Regulation;response;Risk Factors;Role;Severities;Sorting;Stress;Testing;Therapeutic Intervention;Time;tool;Western World;Work

PROJECT_TITLE: The Role of BNIP3 in Lipid Homeostasis in the Liver

STUDY_SECTION_NAME: Fellowships in Digestive Diseases and Nutrition[DDK-F]


NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE  This proposal investigates the role of visual exploration in forming map-like representations of our surroundings. The knowledge gained from this research will be important for developing rehabilitation strategies, assistive devices, and accommodations for those with impaired sight or differences in sensory processing (e.g., from autism and ADHD), who often suffer from navigational difficulties. Moreover, because the brain regions that we plan to study are often impacted by normal aging, stroke, and neurodegenerative diseases such as Alzheimer's disease, knowledge about the role of visuo-spatial processes in these regions will be useful for predicting, diagnosing, understanding, and treating these conditions.

PI_NAMEs: SHAFER-SKELTON, ANNA  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: 3-Dimensional;3D world;Address;Alzheimer's Disease;Animals;Area;Attention deficit hyperactivity disorder;autism spectrum disorder;Back;Brain;Brain region;Cognitive;Computer Models;computing resources;Data;Data Science;design;Detection;Diagnosis;educational atmosphere;Environment;experimental study;falls;Foundations;Functional Magnetic Resonance Imaging;gaze;Goals;Human;Image;Impairment;Individual;Intervention;Knowledge;Link;Literature;Location;Machine Learning;Maps;medial temporal lobe;meetings;Modeling;neural;Neurodegenerative Disorders;Neurosciences;normal aging;novel;Outcome;Participant;Perception;performance tests;Primates;Procedures;Process;Published Comment;rehabilitation strategy;Research;Rewards;Rodent;Role;sample fixation;Scanning;Self-Help Devices;Sensory;Shapes;Stroke;System;Testing;Training;virtual;virtual environment;Vision;vision science;Visit;Visual;Visual impairment;Visual System;visual tracking;Visuospatial;way finding;Work

PROJECT_TITLE: From visual snapshots to allocentric representations of a 3D world

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Contraception/Reproduction

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative The 2024 Gordon Research Conference on Mammalian Reproduction aims to promote the understanding of fundamental processes guiding reproductive functions in mammals, foster new research collaborations and enhance the career development of trainees and junior investigators. We will promote the participation of trainees, women, and individuals from underrepresented groups in all aspects of the program. The overarching goal is to assemble a diverse and international community of experts in reproduction to share cutting-edge discoveries that advance the frontier of research that impacts reproductive medicine and human health.

PI_NAMEs: JORGENSEN, JOAN S (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Achievement;Address;Agriculture;Animals;Area;Atmosphere;Body System;career;career development;career networking;cell type;Cells;Clinical;Collaborations;Communities;Complex;data sharing;Development;doctoral student;Ensure;Environment;ethnic identity;Etiology;Exclusion;experience;Feedback;Fertility;Fostering;frontier;Future;Gametogenesis;Goals;graduate student;Growth and Development function;Health;Human;improved;Individual;International;Joints;Mammals;marginalized community;marginalized population;Modernization;novel strategies;Organ;Participant;Pathologic;Population;Positioning Attribute;Postdoctoral Fellow;Process;Program Development;programs;racial identity;Reproduction;reproductive;Reproductive Biology;reproductive function;Reproductive Medicine;Reproductive Sciences;Research;research and development;Research Personnel;Scientist;Senior Scientist;sexual identity;skills;symposium;Underrepresented Minority;Underrepresented Populations;Woman;Work

PROJECT_TITLE: 2024 Mammalian Reproduction Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Prevention;Rehabilitation

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Currently, the decision to continue using bimodal hearing or pursue a second cochlear implant (i.e., transition from bimodal hearing to bilateral cochlear implant use) is highly subjective, and no clinical guidelines exist to support this decision. Assessing the patient-reported benefits of each listening configuration has been understudied; however, previous literature and our preliminary data suggest that patients hold valuable insights into real-world listening benefits that may differentiate bimodal hearing and bilateral cochlear implants. In this study, we will investigate the patient-reported advantages and limitations of each listening configuration using a novel research approach.

PI_NAMEs: LEWIS, JESSICA HALEY (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Address;Adult;American;Area;Auditory;Bilateral;Caring;Clinical;clinically relevant;Cochlear implant procedure;Cochlear Implants;Code;Complex;Contralateral;Counseling;Data;deaf;design;Detection;Ear;Emotional;evidence base;evidence based guidelines;expectation;Frequencies;Goals;Guidelines;Hearing;Hearing Aids;hearing impairment;improved;Individual;individual patient;individual variation;insight;Institution;Interview;Knowledge;Literature;Measures;Methods;Modality;Music;National Institute on Deafness and Other Communication Disorders;Noise;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Patient Schedules;Patients;Perception;Performance;Phase;Positioning Attribute;Postdoctoral Fellow;Postoperative Period;psychosocial;Recommendation;Reporting;Research;Research Design;Research Methodology;Resolution;shared decision making;social;sound;Sound Localization;Speech;speech recognition;standard care;standard of care;Statistical Data Interpretation;Testing;tool;Training

PROJECT_TITLE: Patient-Reported Benefits of Cochlear Implant Listening Configurations

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Y (58)]


ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE: Actin is a key component of the cellular cytoskeleton that enables cells and tissues to control their shape, and thus is essential for force generation (for example, during embryonic development) and migration (for example, during cancer extravasation), yet we lack the knowledge of how actin structures are coordinated across multiple levels of organization. This project aims to determine how the protein Bitesize, in the Drosophila fly model system, directly interacts with the actin protein to enable the individual actin molecule to assemble into filaments, and to organize these filaments into larger, more intricate structures. Thus, this research seeks to advance the NIH’s mission by establishing knowledge of how cells regulate the hierarchical actin structures that are fundamental to tissue development and disease.

PI_NAMEs: MCDOUGAL, ANTHONY DREW (contact)

PROJECT_TERMS: Acceleration;Actins;Affect;animal tissue;Animals;Architecture;Automobile Driving;Behavior;Binding;Binding Proteins;Biochemistry;Biological Models;Biology;Bundling;Cells;Coupling;crosslink;Cryoelectron Microscopy;Cytoskeleton;Data;Development;Developmental Biology;Disease;Drosophila genus;Drosophila Proteins;Embryo;Embryology;Embryonic Development;Exhibits;Extravasation;F-Actin;Filament;fly;G Actin;gene function;Generations;Genes;Genetic;Goals;human disease;In Vitro;in vitro Assay;in vivo;Individual;innovation;Knowledge;Length;Link;Malignant Neoplasms;Mediating;Membrane;migration;Mission;moesin;Molecular;Morphogenesis;Morphology;mutant;Organism;Phenotype;Protein Biochemistry;Protein Isoforms;Proteins;Regulation;Reporting;Research;Role;Shapes;Structure;synaptotagmin;System;Tissues;Training;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Investigating mechanisms of coordinating actinstructure across multiple levels oforder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]