ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative Several studies have found a positive effect of increasing brain activity levels on rehabilitation outcomes in stroke, but the large heterogeneity among individual patients limits the efficiency of existing stimulation treatments. This application will identify cellular- and system-level mechanisms of post-stroke rehabilitation in rats and link them to motor recovery. Results will introduce the basis for a new paradigm to tailor the treatment protocol to the animal condition, where monitoring brain activity near the injured brain region will provide essential information to tune the treatment parameters and to promote recovery of lost motor skills.

PI_NAMEs: BAKER, KENNETH B;DANA, HOD MICHAEL (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Anatomy;Animal Model;Animals;Brain;Brain Injuries;Brain region;brain tissue;Calcium;Cells;Cerebral cortex;Chronic;Clinical;Clinical Trials;cohort;comparative;Data;Deep Brain Stimulation;Dorsal;effective therapy;efficacy evaluation;Electron Microscopy;Endothelin-1;Female;Frequencies;Generations;Goals;Heterogeneity;Histology;Image;Implant;improved;Individual;individual patient;individualized medicine;Injury;injury recovery;insight;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Limb structure;Link;male;Maps;meter;microstimulation;middle age;Modeling;Monitor;Motor;Motor Cortex;motor deficit;motor recovery;motor rehabilitation;Motor Skills;Neurons;neuroregulation;novel;novel therapeutics;Outcome;Paresis;Pathway interactions;Patients;Phase;Phase I Clinical Trials;Physiologic pulse;Physiological;post stroke;pre-clinical;Process;Property;Quality of life;Rattus;Recovery;Rehabilitation Outcome;Rehabilitation therapy;Resolution;Rodent Model;Sensory;Severities;sex;Sex Differences;Somatosensory Cortex;Stroke;stroke model;stroke recovery;stroke rehabilitation;stroke survivor;Stroke Volume;success;Synapses;synaptogenesis;System;Testing;Therapeutic;Tissues;Training;Translating;treatment effect;Treatment Efficacy;Treatment Protocols;two photon microscopy;vasoconstriction;Visual Cortex;Visualization;Width;Work

PROJECT_TITLE: Calcium imaging-based insights and guidance of deep brain stimulation to enhance chronic, post-stroke rehabilitation in a rodent model of ischemia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Immune checkpoint inhibitors dramatically improve prognosis for many cancer patients but come at the cost of a new class of immune-related adverse events that reduce overall quality-of-life and the net benefit of treatment. This proposal seeks to automatically detect immune-related adverse event phenotypes from the electronic health record to support timely, data-driven cancer care that enhances survivorship. To achieve this goal, we will develop and clinically validate advanced informatics and artificial intelligence technologies, such as deep learning language models, to automate immune-related adverse event monitoring and data collection.

PI_NAMEs: BITTERMAN, DANIELLE S (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Achievement;Address;Adverse event;adverse event monitoring;Artificial Intelligence;Attention;Autoimmune;biobank;Biomedical Research;Boston;cancer care;Cancer Detection;Cancer Patient;Cancer Surveillance Research;cancer survival;Cancer Survivorship;Caring;Classification;Clinical;clinical application;clinical care;clinical phenotype;Clinical Research;clinical translation;clinical trial enrollment;Clinical Trials;clinically significant;Common Terminology Criteria for Adverse Events;computer scientist;Computers;cost;Dana-Farber Cancer Institute;Data;Data Collection;data format;Data Set;data standards;data streams;Databases;deep learning;deep learning model;design;Detection;Development;Diagnosis;Diagnostic;Effectiveness;electronic health data;Electronic Health Record;electronic structure;Eligibility Determination;Enrollment;Environment;follow-up;General Practitioners;Generations;Goals;Health Insurance Portability and Accountability Act;Hospitals;Human;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunologic Monitoring;Impairment;improved;Inflammatory;Informatics;Information Retrieval;innovation;insight;interoperability;Investigation;Knowledge;Label;Language;Language Development;language training;large language model;Malignant Neoplasms;Manuals;Measures;Methods;Modeling;Monitor;Morbidity - disease rate;multidisciplinary;Natural Language Processing;neural;novel;Output;Pathology;Pathway interactions;Patient Monitoring;Patients;Performance;pharmacovigilance;Phenotype;Physicians;pre-trained model;Process;Prognosis;prospective;Quality of life;Randomized, Controlled Trials;Reporting;Research Personnel;Retrieval;Rhode Island;Risk Factors;Severities;Standardization;structured data;survivorship;synthetic data;System;Technology;Text;Translating;tumor;unstructured data;usability;Validation;Work

PROJECT_TITLE: Informatics strategies to improve immune-related adverse event detection in cancer patients

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE There are no approved drug treatments for Mitochondrial Myopathy with a contributory factor being the lack of tools to quantify patient symptoms in past clinical trials. We propose to establish new instruments that we have developed and obtain these measurements in our Mitochondrial Myopathy study population over time. Results will improve the scientific rigor of future Mitochondrial Myopathy clinical trial design.

PI_NAMEs: ZOLKIPLI CUNNINGHAM, ZARAZUELA  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: 5 year old;Address;Adult;Affect;Age;Antioxidants;Assessment tool;Biochemical;Biological Assay;Biological Markers;Child;Classification;Clinic;Clinic Visits;Clinical;Clinical assessments;Clinical Trials;Clinical Trials Design;cohort;COVID-19 pandemic;Data;Databases;design;dexterity;Disease;Disease Progression;DNA;Enrollment;exercise intolerance;Fatigue;FDA approved;frontier;Future;Gender;Genes;Genetic Diseases;Genetic Predisposition to Disease;Glutathione;Growth;heteroplasmy;Image;improved;in vivo;Individual;Institutional Review Boards;instrument;Interview;Ketone Bodies;Longitudinal Studies;longitudinal, prospective study;male;Measurement;Measures;Medicine;Metabolic;Methods;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;Mitochondrial Myopathies;Modeling;Motor;Muscle;Muscle Fatigue;muscle strength;Myopathy;Natural History;novel;Nuclear;Outcome Measure;Oxidation-Reduction;Oxidative Phosphorylation;Pathogenicity;Patient Outcomes Assessments;Patients;Pediatric Hospitals;Performance;Persons;Pharmacologic Substance;Pharmacotherapy;Philadelphia;programs;prospective;Protocols documentation;Quality of life;Quality of Life Assessment;randomized, clinical trials;remote assessment;Reproducibility;Research;response;sex;study population;Subgroup;Symptoms;Testing;Time;tool;trial design;Validation;Variant;Visit

PROJECT_TITLE: Addressing the Research Gap in Mitochondrial Myopathy with Validated Outcome Measures and Natural History

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Neurosciences;Rural Health;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative We will use lessons learned and our success in Phases 1 and 2 to continue our current activities to provide diagnoses for our patients and will also take on new initiatives like focusing on non- genetic disorders, enrolling more patients with health disparities so they can also benefit from the UDN and we will also see more patients than in Phase 2.

PI_NAMEs: SHASHI, VANDANA  (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Address;Adult;Area Health Education Centers;Artificial Intelligence;bioinformatics pipeline;Child;Childhood;clinical research site;Collaborations;Communities;community based participatory research;community collaboration;Cost Analysis;Data;Data Coordinating Center;demographics;design;Diagnosis;Diagnostic;Disease;economic evaluation;Education;Educational workshop;Eligibility Determination;Enrollment;Environmental Exposure;Etiology;Evaluation;exome;experience;family support;Future;gene discovery;Genetic Diseases;Genome;Genome Mappings;Genomic approach;genomic data;Genomic medicine;Genomics;health disparity;health economics;Health Personnel;Health Services Research;implementation framework;Individual;Information Networks;innovation;Knowledge;Leadership;literacy;Medical;medical specialist;medically underserved;Methodology;Minority;Minority Enrollment;minority patient;Mission;non-genetic;non-genomic;North Carolina;novel;Optics;outreach;Pamphlets;Participant;participant enrollment;Patient Participation;patient-level barriers;Patients;Phase;Phenotype;Positioning Attribute;Principal Investigator;Productivity;programs;Provider;provider-level barriers;psychologic;Psychological Impact;Publications;Research;research clinical testing;Resources;Role;Rural;rural counties;Rural Health;Science;Secure;success;support network;Surveys;Technology;transcriptome sequencing;Travel;Underinsured;Update;Validation;Work;working group

PROJECT_TITLE: An integrated and diverse genomic medicine program for undiagnosed diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

ORG_STATE: CA

PHR: PROJECT NARRATIVE The human genome is stored in the nucleus, a compartment segregated by a double membrane which is spanned by large proteinaceous assemblies acting as its exclusive and selective gateways, the so-called nuclear pore complexes (NPCs). As such, defects in the NPC are associated with a broad set of human diseases, including aggressive forms of cancer and neurodegenerative disorders, and its components are commonly targeted by many viruses to dampen the host’s antiviral response. Our research focuses on obtaining atomic-level snapshots of the NPC to understand how it mediates the relay of information encoded by the genome, and how its dysfunction relates to human health and disease.

PI_NAMEs: HOELZ, ANDRE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: 2019-nCoV;Accounting;Address;Anatomy;Anti-viral Response;antiviral drug development;Architecture;Binding;Biochemical;Biological;Biological Assay;Cell Nucleus;Cell Physiology;Cells;Characteristics;Chromatin;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cytoplasm;Cytoplasmic Filaments;dalton;Defect;density;Diffusion;Disease;Dissection;Docking;Eukaryota;Eukaryotic Cell;Event;Face;flexibility;Functional disorder;Future;Genetic;genetic information;Genetic Variation;Genome;Goals;Head;Health;Human;human disease;Human Genome;In Vitro;in vitro activity;in vivo;in vivo evaluation;insight;interdisciplinary approach;Knowledge;Link;Location;macromolecular assembly;Macromolecular Complexes;macromolecule;Malignant Neoplasms;Maps;Mediating;Membrane;messenger ribonucleoprotein;Messenger RNA;Molecular;molecular mass;mRNA Export;Mutation;neoplastic;Nerve Degeneration;Neurodegenerative Disorders;Nuclear;Nuclear Envelope;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Structure;nucleocytoplasmic transport;particle;Physiological;Predisposition;Process;programs;protein folding;protein protein interaction;protein purification;Proteins;Protomer;receptor;Recombinants;reconstitution;reconstruction;recruit;Reporter;Research;Resolution;Rest;Retinal blind spot;Ribonucleoproteins;RNA;RNA Binding;RNA Transport;RNA-Protein Interaction;Role;Sarbecovirus;segregation;Structure;success;Tail;Translations;Validation;Viral;Viral Interference;Viral Pathogenesis;Virulence Factors;Virus;Virus Diseases;Work

PROJECT_TITLE: Molecular Basis of mRNA Export

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lymphatic Research;Lymphedema;Microbiome;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases;Wound Healing and Care

ORG_CITY: KUMASI

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: KWAME NKRUMAH UNIVERSITY/SCIENCE/TECH

PHR: Project Narrative At first glance, lymphatic filariasis (LF) may appear as an obscure tropical disease, overlooked by many and as such there exist no standard protocol in managing LF manifestation and related complications, thus makes this very worrying. LF-associated manifestations, especially lymphedema (LE) involves crisis of recurrent wounds and infections that impacts chronic pain, disfigurement, disability, and economic devastation that disproportionately impacts marginalized communities, trapping them in a cycle of poverty and despair (Asiedu et al., 2022). Understanding the critical importance of this problem is paramount hence, through this comprehensive career development program, we seek to characterise microbial communities that colonise the debilitating chronic filarial wounds associated to help establish LF-specific genomic library that guide evidence-based interventions that empower communities and restore their health and dignity.

PI_NAMEs: KWARTENG, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Attention;care outcomes;Career Choice;career development;Characteristics;Chronic;chronic pain;Clinical;clinical practice;Collaborations;Communities;community empowerment;Country;Data;Data Set;Development;disability;Early Intervention;Economics;evidence base;Evidence based intervention;Experimental Designs;Filarial Elephantiases;Genetic;Genetic Variation;Genomic Library;genomic profiles;Ghana;global health;Goals;Guidelines;Health;Health Priorities;Healthcare;Hunger;Impaired healing;improved;Individual;Infection;infection management;Injury;Intervention;Leadership;Life;Limb structure;low and middle-income countries;Lymphatic System;Lymphedema;marginalized community;Medical;Mentorship;microbial;Microbial Biofilms;microbial community;microbial signature;microbiome;Minor;Molecular;neglect;Outcome;Outcomes Research;pathogen;Patient-Focused Outcomes;Patients;Pattern;Policies;Population;Poverty;prediction algorithm;Prevalence;Process;Program Development;programs;Protocols documentation;Public Health;Recurrence;recurrent infection;Research;Research Project Grants;Resistance;resistance mechanism;resistant strain;Resource-limited setting;Resources;Site;skills;Skin;socioeconomics;Technology;Time;Translating;Tropical Disease;Variant;wound;wound care;wound healing;wound treatment

PROJECT_TITLE: Microbiome profiling of non-healing filarial lymphedema wounds in Ghana.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation;Sleep Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of therapeutic interventions such as deep brain stimulation on sleep-related neuronal activity and sleep behavior, are not well understood. Results from this preclinical study will provide a better understanding of the brain circuitry involved in disordered sleep in parkinsonism and inform the development of targeted therapeutic interventions to treat sleep disorders in people with neurodegenerative disease.

PI_NAMEs: JOHNSON, LUKE AARON (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Affect;Animals;Basal Ganglia;Behavior;Biological Markers;Brain;brain circuitry;Cell Nucleus;Cells;Chronic;clinical care;Coupling;Data;Deep Brain Stimulation;Development;Disabling;Dorsal;Dose;Drowsiness;Evolution;Excessive Daytime Sleepiness;Exhibits;Fiber;Frequencies;Functional disorder;Ganglia;Globus Pallidus;Goals;Human;improved;improvement on sleep;Individual;individual patient;insight;Intervention;invention;Knowledge;Measures;Modeling;Motor;Motor Activity;Motor Cortex;motor symptom;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neurophysiology;Neurotoxins;non rapid eye movement;nonhuman primate;Outcome;Output;Parkinson Disease;Parkinsonian Disorders;Pathway interactions;Patients;Persons;Physiological;Play;Polysomnography;Population;preclinical study;Protocols documentation;Quality of life;Regulation;REM Sleep;Reporting;Resistance;Rodent;Role;Secondary to;Severities;Signal Transduction;Site;Sleep;Sleep Architecture;sleep behavior;Sleep Disorders;Sleep Disorders Therapy;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep regulation;Sleep Stages;Sleep Wake Cycle;Slow-Wave Sleep;STN stimulation;Structure;Structure of subthalamic nucleus;Substantia nigra structure;targeted treatment;Thalamic structure;Therapeutic;Therapeutic Effect;Therapeutic Intervention;Time;Travel;wireless;Work

PROJECT_TITLE: The effects of parkinsonism and deep brain stimulation on basal ganglia-thalamocortical circuitry during sleep-wake behavior

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative We will determine the mechanisms by which substance P produces lethal bronchoconstriction and greatly potentiated eosinophilic inflammation after allergen challenge in offspring exposed to maternal asthma. Our findings will identify new therapeutic targets to address this novel tachykinin asthma phenotype.

PI_NAMEs: DRAKE, MATTHEW G. (contact);FRYER, ALLISON DEBORAH;JACOBY, DAVID B

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Address;afferent nerve;airway hyperresponsiveness;Allergens;antagonist;Antigens;Asthma;asthmatic;Atropine;Biopsy;Bronchoconstriction;Cell Communication;Chemotactic Factors;Confocal Microscopy;cytokine;Data;Dendritic cell activation;Dendritic Cells;density;Drug Targeting;Enterobacteria phage P1 Cre recombinase;eosinophil;eosinophilic asthma;eosinophilic inflammation;Eotaxin;Exposure to;Fiber;Flow Cytometry;G-Protein-Coupled Receptors;Genetic;histological studies;Human;IL5 gene;in vivo;Inflammation;Inflammatory Response;Inhalation;Interleukin-5;lens;Link;LoxP-flanked allele;Lung;Measurement;Measures;Mediating;member;Methodology;Modernization;Mothers;Mus;MYH11 gene;Nerve;nerve supply;Neurons;Neuropeptides;new therapeutic target;novel;offspring;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;prenatal exposure;programs;Publications;Pyroglyphidae;recruit;Reflex action;response;Role;Sensory;Serotonin;Severity of illness;Signal Transduction;Smooth Muscle;Stimulus;Structure;Substance P;Tachykinin;TACR1 gene;Testing;Transgenic Mice;Transgenic Organisms

PROJECT_TITLE: Mechanisms of tachykinergic nerve-mediated severe bronchoconstriction and inflammation

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Relevance: Sensory cortices undergo substantial changes during learning of behaviorally important information. In this proposal, we will elucidate how sound-evoked adenosine release controls synaptic and cortical plasticities in the murine auditory cortex and affects perceptual performance.

PI_NAMEs: ZAKHARENKO, STANISLAV S (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acoustic Stimulation;Acoustics;Address;Adenosine;Adolescent;Adult;Affect;age related decline;Area;Astrocytes;Auditory;Auditory area;Auditory Perception;Auditory system;auditory thalamus;awake;Basal Nucleus of Meynert;Behavioral;Behavioral Mechanisms;Calcium;Cerebral cortex;Characteristics;cholinergic;cortex mapping;critical period;Data;Development;Discrimination;Disinhibition;environmental enrichment for laboratory animals;Equilibrium;Event;excitatory neuron;experience;experimental study;Exposure to;extracellular;Frequencies;G-Protein-Coupled Receptors;Gatekeeping;Genetic;Glutamates;Image;Impairment;improved;Individual;Inferior Colliculus;inhibitory neuron;Language Development;Learning;Life;mature animal;Measures;Methods;Mus;neural;neural circuit;Neuromodulator;Neuronal Plasticity;neuroregulation;novel;Nucleoside Transporter;Nucleotidases;optogenetics;Organism;Performance;Periodicity;pharmacologic;Production;Property;pup;Reporting;response;Rodent;Role;Scanning;Science;sensor;Sensory;sensory cortex;sensory input;sensory stimulus;Signal Transduction;Signaling Molecule;Site;sound;sound frequency;Source;spatiotemporal;Stimulus;Synapses;Synaptic plasticity;System;temporal measurement;Testing;Thalamic structure;Training;two-photon;uptake;Ventral Tegmental Area;Wakefulness

PROJECT_TITLE: Sensory-evoked adenosine release in cortical plasticity

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Gene Therapy;Genetics;Nanotechnology;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE: Efficient, non-toxic delivery of nucleic acid sequences into the cytosol remains the largest bottleneck precluding the development of potent RNA interference technologies that combat diseases in a non-palliative manner. Accelerated treatment of chronic diabetic wounds, our specific disease model of interest, remains a major ongoing challenge in medicine.

PI_NAMEs: MONTCLARE, JIN KIM (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Acceleration;Address;Amino Acid Sequence;Ammonium;Antigen-Antibody Complex;Base Sequence;Binding;Biocompatible Materials;biomaterial compatibility;Capsid;Cell membrane;Cells;Cellular Infiltration;Characteristics;Chemicals;Chronic;chronic wound;Clinical;clinical translation;combat;cost;Cytosol;cytotoxic;cytotoxicity;delivery vehicle;design;Development;Diabetes Mellitus;Diabetic mouse;diabetic ulcer;Digestion;Disease;disease model;Dose;effective therapy;Effectiveness;Endocytic Vesicle;Endocytosis Pathway;Endosomes;Environment;Enzymes;Epitopes;Formulation;Foundations;Gene Delivery;Gene Expression;Generations;Genes;Goals;Health Care Costs;Homeostasis;Hybrids;Hyperglycemia;Immune response;Immune system;immunogenic;improved;In Vitro;in vivo;Incidence;Infiltration;inhibitor;innovation;interest;knock-down;Libraries;Lipids;Liposomes;Major Histocompatibility Complex;Masks;Medicine;Membrane;Methods;Modeling;mouse model;Mus;mutant;nanoparticle;Non-Viral Vector;novel;nuclease;Nucleic Acid Binding;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;Outcome;Oxidation-Reduction;Pathologic;Pathologic Processes;Pathway interactions;Penetration;Peptide Hydrolases;Peptides;Phenotype;pre-clinical;Predisposition;Propane;Property;Protein Engineering;Proteins;Rare Diseases;rational design;receptor;Recombinant Proteins;Research;Research Personnel;Reticuloendothelial System;Ribonucleases;Risk;RNA Binding;RNA Interference;RNA Sequences;Role;Safety;Scaffolding Protein;self assembly;siRNA delivery;Site;Skin;skin disorder;Skin repair;skin wound;Small Interfering RNA;Sodium Cholate;Structure;Surface;System;Techniques;Technology;technology platform;Testing;Therapeutic;therapeutic RNA;Time;tissue repair;Tissues;trafficking;Transfection;transgene expression;translational impact;translational potential;uptake;Validation;Viral;Viral Vector;Virus;Work;wound healing;Wound models

PROJECT_TITLE: Modular Toolbox of Protein and Lipid Hybrid Biomaterials for siRNA Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness;Suicide

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE FOR ADDICTION AND MENTAL HEALTH

ORG_STATE: ON

PHR: PROJECT NARRATIVE A first episode of psychosis is a leading cause of disability in young adults, with high risk of suicide and all-cause mortality. A substantial part of the burden and cost relates to poor functional outcomes, and the inability to determine the right antipsychotic treatment during the earliest phases of psychotic illness, particularly for those who might need clozapine, a medication that is already known to work best for those who do not respond to conventional antipsychotics. In patients with a first episode of psychosis, the present study aims to determine whether the use of biomarker-guided treatment decisions leads to better outcomes and equivalent side effects in people prescribed clozapine compared to conventional antipsychotics, including changes in brain function.

PI_NAMEs: VOINESKOS, ARISTOTLE NICHOLAS (contact)

PROGRAM_OFFICER_NAME: RUDORFER, MATTHEW V

PROJECT_TERMS: Acceleration;acute care;Adherence;Adolescence;Age;aged;Agranulocytosis;Antipsychotic Agents;aripiprazole;Biological Markers;blind;Brain;Brain scan;Caring;Clinical;Clozapine;cohort;Complex;Controlled Study;Corpus striatum structure;cost;Country;critical developmental period;critical period;Data;Decision Making;Dedications;Development;disability;dissemination strategy;Dose;early psychosis;Education;efficacy evaluation;efficacy trial;Elements;emerging adult;Employment;expectation;experience;Failure;Family;Family member;Feeling suicidal;first episode psychosis;Functional Magnetic Resonance Imaging;functional MRI scan;functional outcomes;Future;General Population;genetic testing;genomic locus;Genotype;Goals;high risk;HLA-DQB1;Hospitalization;Hospitals;Image;implementation science;improved;improved outcome;indexing;Individual;inpatient service;Lifelong disability;Lived experience;Magnetic Resonance Imaging;Melanocortin 4 Receptor;mortality;National Institute of Mental Health;Neutropenia;Outcome;Patient-Focused Outcomes;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacogenetics;Phase;Population;Precision therapeutics;predicting response;predictive marker;preservation;primary outcome;Psychiatry;Psychoses;psychotic;Psychotic Disorders;Publishing;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Receptor Gene;reducing suicide;Research Design;Resistance;responders and non-responders;response;Rest;Risk;risk variant;Risperidone;Schizophrenia;secondary outcome;Services;side effect;specific biomarkers;Subgroup;suicidal morbidity;suicidal risk;support tools;Symptoms;System;Testing;Therapeutic;tool;treatment response;trial comparing;Weight;Weight Gain;Work;young adult;Youth

PROJECT_TITLE: 1/5 Biomarkers to Enhance Early Schizophrenia Treatment (BEEST)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-S (60)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Congenital Structural Anomalies;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Rare Diseases;Regenerative Medicine;Spina Bifida;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Spina bifida affects approximately 2,500 live births per year in the United States, making this malformation amongst the most common of all human birth defects with a significant public health concern. The proposed research program addresses novel minimally-invasive intervention strategies to mitigate the impact of birth defects associated with spina bifida.

PI_NAMEs: CORRADETTI, BRUNA  (contact);FINNELL, RICHARD H.;TARABALLI, FRANCESCA

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: Address;Affect;amniotic cavity;Amniotic Fluid;amniotic fluid derived stem cell;Animal Model;Ankle;Area;Back;Biodistribution;Biological Models;Biomedical Engineering;Biomimetics;Bladder;Caregivers;Cell Therapy;Cells;Cerebrospinal Fluid;Child Development;Clinical;Clinical effectiveness;clinical practice;clinically relevant;comorbidity;Complex;Congenital Abnormality;Data Set;Defect;Development;Diagnosis;Economics;Effectiveness;efficacy evaluation;embryo culture;embryo surgery;Embryonic Development;Environment;Etiology;exosome;experience;Extravasation;Family;feasibility testing;Fetus;forging;Gel;Generations;Genetic;Genetically Modified Animals;Goals;Health;hindbrain;House mice;Human;Hyaluronic Acid;Impairment;Implant;improved;improved mobility;in utero;in vivo;Infant;Injections;Interdisciplinary Study;Intervention;Intestines;Knockout Mice;Knowledge;Leg;Lesion;Lifelong disability;Liquid substance;Live Birth;malformation;materials science;Mechanics;Medical;Meningomyelocele;Messenger RNA;minimally invasive;Modeling;Molecular;mouse model;Mus;nanomedicine;Natural regeneration;Nervous System Trauma;Neural tube;Neural Tube Defects;Neural Tube Development;novel;Operative Surgical Procedures;Oryctolagus cuniculus;Outcome;Paste substance;Pathogenesis;Penetrance;Placenta;placental stem cell;postnatal;Pregnancy;prenatal exposure;prenatal therapy;preservation;Prevalence;prevent;Procedures;programs;Public Health;regeneration potential;regenerative;repaired;Research;Route;Severities;Shunt Device;Site;social;Spinal Cord;Spinal Dysraphism;Spinal nerve structure;stem;stem cell biology;Stem Cell Development;stem cell therapy;stem cells;success;Syringes;System;Temperature;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tissue degeneration;tissue repair;Tissues;Treatment Efficacy;United States

PROJECT_TITLE: Biomimetic intervention strategies for endogenous in utero repair of Spina Bifida

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Genetics;Human Genome;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Tobacco;Tobacco Smoke and Health

PHR: Public Health Relevance: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality, but we have not yet discovered treatments that significantly reverse the lung damage of COPD. In this project, we will study an important cell type for COPD, human airway epithelial cells (HAECs), and we will understand how genetic differences between individuals can increase risk for COPD by their effects on alternative splicing in HAECs. We will use advanced long read sequencing and proteomic technologies, as well as deep learning models of alternative splicing to identify how COPD-causing genetic differences that affect splicing have broader effects on the biological processes and cellular functions of HAECs.

PI_NAMEs: CASTALDI, PETER  (contact);TESFAIGZI, YOHANNES

PROGRAM_OFFICER_NAME: GAN, WEINIU

PROJECT_TERMS: Affect;Air;airway epithelium;Alternative Splicing;Bayesian Method;Biological;Biological Process;Biology;Blood;Cause of Death;Cell Physiology;cell type;Cells;Cellular biology;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoking;Collection;Complement;Complex;computer science;Data;deep learning;deep learning model;Development;disability;Disease;Drug Targeting;Environmental Exposure;Epithelial Cells;exposure to cigarette smoke;FDA approved;fine art;Functional disorder;Gene Expression;gene network;gene regulatory network;Genes;Genetic;genetic predictors;Genetic Predisposition to Disease;genetic variant;Genome Mappings;genome wide association study;genome-wide;Genomics;Genotype;Goals;Human;human data;Human Genetics;human subject;improved;Individual;Interdisciplinary Study;Investigation;knock-down;Liquid substance;Lung;lung injury;Machine Learning;Maps;Mass Spectrum Analysis;Measurement;Methods;Modeling;mortality;multiple omics;network models;new therapeutic target;Pathogenicity;Pathway Analysis;Pathway interactions;Performance;Phenotype;Play;predictive modeling;Protein Isoforms;Proteins;Proteomics;public health relevance;pulmonary function;Quantitative Trait Loci;Research;Research Priority;Resources;response;Risk;RNA;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Science;sequence learning;small hairpin RNA;Small Interfering RNA;Source;Spliced Genes;Structure of parenchyma of lung;Technology;TGFB1 gene;TGFB2 gene;Tissue Sample;Tissues;tool;Training;trait;transcriptome;transcriptome sequencing;Transforming Growth Factor Beta 2;Translational Research;Variant;Work

PROJECT_TITLE: COPD GWAS Functional Variant Identification in Airway Epithelial Cells using Deep Learning Splicing Models

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: Cognitive fluctuations – called “the Lewy Roller Coaster” by families – are a debilitating symptom of Lewy body disorders, including Parkinson’s Disease (PD) and Lewy Body Dementias (LBD). This proposal seeks to model cognitive fluctuations using alpha-synuclein in the ascending arousal network with the hope of understanding underlying mechanisms and uncovering targets for treatment.

PI_NAMEs: ALDRIDGE, GEORGINA  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Acute;Address;Adrenergic Receptor;Affect;alpha synuclein;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Animal Model;Arousal;Attention;Autopsy;awake;Axon;Brain;Brain Diseases;Brain Stem;Cell Count;Cell Nucleus;Cells;Cellular Morphology;Cephalic;Chronic;circadian;Cognition;Cognitive;cognitive change;Coma;Data;debilitating symptom;Dementia;Dementia with Lewy Bodies;Development;Diagnosis;Diagnostic;Disease;Dorsal;Dose;effective therapy;Electrodes;Electroencephalography;Excessive Daytime Sleepiness;Exposure to;Family;flexibility;Frequencies;Goals;Guanfacine;Head;high risk;Home;Hour;Human;Image;Impairment;improved;in vivo;Individual;Injections;insight;Knowledge;Laboratories;Lesion;Lewy Bodies;Lewy Body Dementia;Lewy Body Disease;Literature;locus ceruleus structure;Maintenance;Measures;Methods;Microdialysis;Modeling;mouse model;Mus;Neuromodulator;Neurons;neuroregulation;neurotransmitter release;novel;Outcome;overexpression;parabrachial nucleus;Parkinson Disease;Parkinson's Dementia;Pathology;Patients;Persons;pharmacologic;Population;pre-formed fibril;Prefrontal Cortex;Process;Proteins;Publishing;recruit;Research;response;Sleep;Sleep Architecture;Speed;Stimulus;Surrogate Markers;Symptoms;System;Techniques;Testing;Time;Toxin;Transgenic Organisms;two-photon;United States;Ventral Tegmental Area;vigilance;Wakefulness;Work

PROJECT_TITLE: Vulnerability of the ascending arousal network to alpha-synuclein pathology

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Natural transformation is a multi-step process used by bacteria to take up DNA from the environment, thereby acquiring new traits. These include genes that contribute to antibiotic resistance, virulence, and immune evasion. This proposal will elucidate the three major steps of bacterial transformation: the uptake of DNA from the environment across the cell wall, the transport of DNA across the membrane into the cytoplasm, and the recombination of DNA into the recipient cell chromosome.

PI_NAMEs: DUBNAU, DAVID A (contact);NEIDITCH, MATTHEW B

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Antibiotic Resistance;ATP phosphohydrolase;Bacillus subtilis;Bacteria;Bacterial Transformation;Binding;Biochemical;Biochemistry;Bioinformatics;biophysical analysis;Biophysics;Black Box;Cell membrane;Cell Wall;Cells;Cellular biology;Chromosomes;Collaborations;Complex;Cytoplasm;DNA;DNA Binding;DNA Binding Domain;DNA Structure;DNA-Binding Proteins;endonuclease;Environment;Evolution;experience;Genes;Genetic;Genetic Recombination;Genetic Transformation;Genome;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Horizontal Gene Transfer;Immune Evasion;in silico;insight;laser tweezer;Measures;Membrane;Methodology;Methods;Modeling;Molecular;Molecular Biology;Mutagenesis;neglect;optic tweezer;Pathway interactions;Peptidoglycan;periplasm;Physical condensation;Physiology;Play;Positioning Attribute;Process;Protein Biochemistry;protein complex;Protein translocation;Proteins;Recording of previous events;Research Personnel;resistance gene;Resolvase;Roentgen Rays;Role;single molecule;Single-Stranded DNA;structural biology;Structure;Testing;Thick;tool;trait;Transport Process;uptake;Virulence;virulence gene;X-Ray Crystallography

PROJECT_TITLE: Understanding the mechanism of genetic transformation

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurodegenerative;Palliative Care;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative  The proposed research is relevant to public health because the study aims to adapt and finalize our web app based on acceptance and commitment therapy for family caregivers of people with dementia and to test its feasibility, acceptability, and usability. The greatest unmet need in these caregivers is support for mental health, and the findings will contribute to the timely development of an evidence- based, easily accessible mental health app. Thus, the proposed research is relevant to the National Institutes of Health’s mission of enhancing human health.

PI_NAMEs: HAN, AREUM  (contact);LEE, HEE YUN

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Adherence;aging in place;Anxiety;Artificial Intelligence;Back;Behavior;behavior change;Caregiver support;Caregivers;caregiving;Caring;Clinical Trials;Collaborations;community advisory board;coping;cost;Data;Dementia;Dementia caregivers;depressive symptoms;design;Development;diagnostic strategy;Distress;Dropout;Emotions;Equilibrium;Evaluation;evidence base;experience;Family Caregiver;Family psychotherapy;Feasibility Studies;feasibility testing;Feedback;Feeling;flexibility;Future;Goals;Grief reaction;Guilt;Health;Human;improved;Individual;Internet;internet delivery;Intervention;Interview;Learning;Life;Mental Depression;Mental Health;Mental health promotion;Methods;mindfulness;Mission;Modification;Online Systems;Outcome;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Phase;phenomenological models;Pre-Post Tests;prevent;Process;programs;prototype;psychoeducation;psychologic;psychological distress;Public Health;Questionnaires;recruit;Reporting;Research;Research Design;response;scale up;Schedule;Self Care;self help;Services;Severities;skills;skills training;Stress;Symptoms;Target Populations;targeted treatment;Testing;Thinking;United States National Institutes of Health;usability;web app

PROJECT_TITLE: Adaptation and feasibility testing of an AI-enabled web app based on acceptance and commitment therapy for family caregivers of people with dementia

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Rare Diseases

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE Cholera was introduced into Haiti in 2010, with over 820,000 reported cases and close to 10,000 deaths. After the initial epidemic peak, case numbers declined, with no clinical cases officially reported after February 2018 until September 2022, when cholera recurred in epidemic form. The current proposal explores causes for the 2022 recurrence of cholera in Haiti.

PI_NAMEs: MORRIS, JOHN GLENN (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Address;Antibody titer measurement;Area;Artificial Intelligence;artificial intelligence model;Automobile Driving;Bacteriophages;Biological Models;Case Study;Cessation of life;Characteristics;Cholera;Cholera Vaccine;Clinical;clinical database;cohort;Collaborations;Communities;Complex;Country;Data;Disease;Disease Outbreaks;Effectiveness of Interventions;Environment;Epidemic;Evolution;exhaust;Floods;future epidemic;genetic analysis;Government;Grant;Haiti;Haitian;Hospitalization;Immune response;Immunity;Infection;infection rate;Infrastructure;Intervention;Island;Laboratories;Medical Research;Microbial Biofilms;Modeling;Monitor;Morbidity - disease rate;mortality;new epidemic;Patients;Pattern;Periodicals;Polysaccharides;Population;population movement;Positioning Attribute;Predatory Behavior;Prevention;Production;Public Health;Recurrence;Reporting;Research;Research Institute;Resistance;Serotyping;Site;Source;Surface;Time;Toxic effect;Vaccination;Vibrio cholerae;Vibrio cholerae O1;Virulence;War;whole genome

PROJECT_TITLE: Recurrence of Cholera in Haiti: Exploration of Contributing Factors and Intervention Strategies

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Cardiac fibrosis contributes to the progression of heart failure, but there is no FDA-approved drug specifically targeting cardiac fibrosis due to the lack of understanding of the underlying mechanism and a reliable drug discovery platform. This proposal will leverage state-of-the-art iPSC biology, tissue engineering, animal models, and single-cell multiome analyses to elucidate the underlying mechanisms for cardiac fibrosis. We expect to identify new treatments for patients with cardiac fibrosis and heart failure which is an unmet need.

PI_NAMEs: LIAO, RONGLIH ;MERCOLA, MARK ;WU, JOSEPH C. (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: 3-Dimensional;absorption;Aging;Animal Model;ATAC-seq;Bioinformatics;Biomechanics;Cardiac;cardiac tissue engineering;Cardiomyopathies;Cell Communication;Cell Line;Cell Nucleus;cell type;Cells;Chromosome Mapping;Circulation;Clinical;Coculture Techniques;Collaborations;coronary fibrosis;differentiation protocol;Dilated Cardiomyopathy;DNA Damage;drug discovery;Drug Kinetics;Echocardiography;Endothelial Cells;epigenome;Excretory function;experimental study;Extracellular Matrix Proteins;FDA approved;Fibroblasts;Fibrosis;Generations;Genetic Predisposition to Disease;genome sequencing;genomic platform;Genotype;Heart;Heart failure;heart function;high throughput screening;Histology;human induced pluripotent stem cells;In Vitro;Individual Differences;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;Journals;Libraries;Measures;Metabolism;Methodology;Modeling;mouse model;multiple omics;mutant;Mutation;Myocardial;Myocardial dysfunction;Myocardial Ischemia;Myofibroblast;novel;Paper;patient derived induced pluripotent stem cells;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Process;profibrotic cytokine;Property;Publishing;Qi;Regulation;Reporter;Research Personnel;response;senescence;Severities;Signal Pathway;small molecule;stem cell biology;stem cells;Stimulus;systemic toxicity;Therapeutic;Therapeutic Effect;Time;Tissue Engineering;Tissue Model;Tissues;transcriptome;transcriptome sequencing;transcriptomics;whole genome

PROJECT_TITLE: Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE This proposal seeks to define causal and consequential mechanisms of DNA methylation dysregulation that is an epigenetic hallmark of colon cancer. Deep mechanistic insight into DNA methylation regulatory mechanisms has great potential for revealing root causes of tumorigenesis and novel strategies for colon cancer therapy.

PI_NAMEs: ROTHBART, SCOTT  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Address;Binding;Binding Sites;Biological Models;cancer cell;Cancer Etiology;cancer therapy;cancer type;Cell Aging;Cell division;Cells;Cessation of life;Chromatin;Clinical;clinical efficacy;clinically relevant;Colon;colon cancer treatment;Colon Carcinoma;colon tumorigenesis;CpG Islands;Data;Development;Disease;DNA;DNA Methylation;DNA methyltransferase inhibition;DNA Methyltransferase Inhibitor;DNA Modification Methylases;DNA Transposable Elements;Enzymes;epigenetic drug;Epigenetic Process;epigenome;Evolution;Gene Expression Regulation;Gene Silencing;Genome;Genomic Imprinting;Genomic Instability;Genomic Segment;Goals;Histone H3;histone methylation;Histones;Hypermethylation;insight;Intergenic DNA;Intestines;Knowledge;Ligase;Link;Maintenance;Malignant Neoplasms;men;Methylation;methylation pattern;Methyltransferase;Mitotic;Modification;Molecular;Monoubiquitination;non-histone protein;novel;novel strategies;Oncogenic;Organoids;overexpression;Pathway interactions;Play;Post-Translational Protein Processing;promoter;Proteins;Reading;recruit;Regulation;Repression;Role;Shapes;Signal Transduction;Testing;Therapeutic;Transcriptional Silencer Elements;treatment strategy;Tumor Suppressor Genes;tumorigenesis;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;Ubiquitination;United States;Woman;Work;X Inactivation

PROJECT_TITLE: Mechanisms of DNA methylation signaling and dysregulation in colon cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Prevention;Substance Misuse

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Opioid use disorders are characterized by the development of tolerance, escalation of use, and withdrawal upon abstinence, leading to compulsive use in some individuals. In this proposal, we explore the role of habenula- interpeduncular circuit activity at the molecular and cellular levels in behavioral expression of tolerance and withdrawal to oxycodone and probe whether NOS1 is critical for these drug adaptations. We hope that our findings may open new avenues of research for development of therapies to treat addiction.

PI_NAMEs: ABLES, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Abstinence;Acute;addiction;Adult;Affect;Affective;Analgesics;Behavior;Behavioral;behavioral tolerance;Binding;Biological Assay;Calcium;cholinergic;Chronic;chronic pain patient;clinical practice;Consumption;Data;Development;Dose;drinking water;Drug Exposure;effective therapy;Exposure to;feasibility testing;Feedback;Female;Fentanyl;Fiber;Foundations;Future;Gene Expression;Gene Expression Profile;Goals;Habenula;Home;Individual;insight;Intake;interpeduncular nucleus;Intoxication;knock-down;male;Medial;Mediating;Mediator;Medical;Molecular;Molecular Target;Moods;mu opioid receptors;multidrug abuse;multidrug tolerance;Mus;neural;Neurons;next generation sequencing;Nicotine;Nicotine Withdrawal;Nitric Oxide Synthase Type I;novel therapeutics;Opiate Addiction;opiate tolerance;Opioid;opioid epidemic;opioid use disorder;opioid withdrawal;Oral;Overdose;overdose death;Oxycodone;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Photometry;Play;postsynaptic;Pre-Clinical Model;prescription opioid;presynaptic;Presynaptic Terminals;prevent;Prevention;Psychiatry;Publishing;Regulation;research and development;response;reward circuitry;Rewards;Ribosomes;Role;Solid;suicidal risk;synthetic opioid;Testing;Therapeutic;therapeutic development;therapeutic target;therapy development;Time;transcription factor;United States;Up-Regulation;Viral;Withdrawal;Work;Zinc

PROJECT_TITLE: Molecular and Cellular Profiling of the Habenulointerpeduncular Circuit in Opioid Tolerance and Withdrawal

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Sepsis;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Here we propose to create a unique resource, the Sepsis ClinicAl Resource And Biorepository (SCARAB) registry comprising prospectively enrolled sepsis patients and critically ill control patients, their complete, de-identified medical records, automated phenotyping algorithms, and a complement of serial biological specimens to be used by the sepsis research community.

PI_NAMEs: BASTARACHE, JULIE ANNE (contact);WARE, LORRAINE B

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Academic Medical Centers;Acute Respiratory Distress Syndrome;Adult;Affect;Age;Antibiotics;antimicrobial;aspirate;biobank;Bioinformatics;Biological;Biological Factors;biological heterogeneity;biomedical informatics;Blood;Blood specimen;career;Caring;Censuses;Cessation of life;Child;Childhood;Clinical;Clinical Data;clinical phenotype;Collection;Communities;Complement;concept mapping;Coupled;Critical Illness;Data;Data Collection;data de-identification;data modeling;Data Security;Data Set;data sharing;Delirium;design;Development;Distal;DNA;Electronic Health Record;Elements;Enrollment;epidemiology study;ethnic diversity;experience;Functional disorder;Gene Expression;Genetic;Heterogeneity;Hospitals;Human;Image;Immune response;indexing;injured;innovation;Institution;interest;Link;Liquid substance;Lung;lung microbiome;Manuals;Mechanical ventilation;Medical Records;medical schools;Methodology;Methods;microbial;Microbiology;Minority Groups;Molecular;multidisciplinary;multiple omics;Natural Language Processing;novel;Observational Study;Online Systems;Organ;Organ failure;organ injury;Outcome;Outcome Study;participant enrollment;pathogen;Pathologic;patient population;Patients;Persons;Phase;Phenotype;phenotyping algorithm;Plasma;predictive marker;Process;prospective;Prospective Studies;Protocols documentation;racial diversity;Registries;Reproducibility;Research;Research Design;Research Personnel;Resources;respiratory;Risk;Risk Factors;sample collection;Sampling;scale up;screening;Security;Sepsis;Sepsis Syndrome;septic patients;sociodemographics;Socioeconomic Factors;socioeconomics;Specimen;Supportive care;Syndrome;targeted treatment;Testing;Trachea;Urine;Validation;ventilation;web portal;Whole Blood

PROJECT_TITLE: The Sepsis ClinicAl Resource And Biorepository (SCARAB) Project

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Genetics;Intellectual and Developmental Disabilities (IDD);Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: (Did not change) Dietary intake of the essential nutrient choline is typically below requirements; although supplemental choline improves cognitive outcomes in those who experience heavy prenatal alcohol exposure (PAE), how it confers this benefit is unclear. This proposal tests the hypothesis that polymorphisms in genes known to alter choline needs also alter vulnerability to the behavioral deficits that typify those with PAE; these variants may identify those who benefit most from choline intervention. Findings inform the mechanisms underlying choline’s protective action and facilitate optimization of choline interventions for alcohol-exposed pregnancies and those who experienced PAE.

PI_NAMEs: MOONEY, SANDRA M;SMITH, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Affect;alcohol exposure;alcohol intervention;Alcohols;Alleles;at-risk pregnancies;Behavior;behavior influence;behavior measurement;Behavioral;behavioral outcome;Brain;Candidate Disease Gene;candidate identification;Carbon;Child;Choline;choline transporter;clinically relevant;Cognition;Cognitive;cognitive ability;cognitive disability;cohort;Consumption;Data;Data Set;Databases;design;Development;dietary;Dietary intake;Dietary Practices;experience;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Formyltetrahydrofolates;Funding;Future;Genes;Genetic;Genetic Polymorphism;genome wide association study;Genotype;Impaired cognition;improved;improved outcome;Individual;insight;Intake;Intervention;Intervention Trial;lead candidate;Link;Mediating;Memory;Metabolism;methyl group;Micronutrients;Minor;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;Neuroanatomy;neurobehavior;novel;Nutrient;nutritional genomics;Outcome;Oxidoreductase;personalized medicine;Phenotype;Pilot Projects;Play;Population;pre-clinical;Pre-Clinical Model;prenatal;prenatal experience;Reporting;response;Risk;Role;Testing;Variant

PROJECT_TITLE: Choline-Related Polymorphisms in Fetal Alcohol Spectrum Disorders

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;HIV/AIDS;Infectious Diseases;Prevention;Sexually Transmitted Infections;Topical Microbicides;Women's Health Research

ORG_CITY: MONROVIA

ORG_NAME: OAK CREST INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE Multipurpose prevention technologies (MPTs) coupling a broad-spectrum antiviral agent against HSV, and other sexually transmitted infections, with a contraceptive offer user-controlled convenience with the potential to drive product use. We will use state-of-the-art biology, chemistry, biomedicine, and pharmacology to develop novel nonhormonal contraceptives and formulate them with a lead antiviral peptide into an innovative intravaginal ring for extended delivery. The proposed research is relevant to public health, in the U.S. and globally, because a convenient, user-administered MPT will slow the spread of sexually transmitted infections and decrease unintended pregnancies.

PI_NAMEs: BAUM, MARC MICHAEL (contact)

PROGRAM_OFFICER_NAME: GLOCK, JONATHAN A

PROJECT_TERMS: Adenylate Cyclase;Adherence;Adopted;Affinity;Age;Anti-viral Agents;Anti-viral Therapy;avoid pregnancy;Biochemical;Biological Assay;Biology;Characteristics;Chemicals;Chemistry;Clinical;Clinical Trials;Coitus;Collaborations;Contraceptive Agents;Contraceptive methods;contraceptive target;Coupled;Coupling;Data;design;Development;Disease;Dose;Drug Combinations;Drug Delivery Systems;Drug Interactions;Drug Kinetics;drug release kinetics;Effectiveness;Ensure;Enzymes;Epidemic;Evaluation;Excipients;experience;female reproductive tract;Fertilization in Vitro;Formulation;genital herpes;Genitalia;Goals;Health Benefit;Herpes Simplex Infections;Herpesvirus 1;High Risk Woman;HIV;Hormones;Human;Human Herpesvirus 2;Human Papillomavirus;Hybrids;improved;In Vitro;in vivo;Individual;Infection;inhibitor;innovation;interest;Knowledge;Lead;lead candidate;Lesion;Libraries;male fertility;Membrane;meter;Methods;Modality;Mus;next generation;novel;Oocytes;Oral;Pathogenesis;pathogenic microbe;Peptides;Periodicals;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;pre-clinical;Pre-Clinical Model;pre-exposure prophylaxis;prevent;Prevention;Prevention therapy;Process;Property;prototype;Public Health;Regimen;reproductive;Research;Research Personnel;residence;Risk;Safety;scale up;sex;Sexually Transmitted Diseases;Sheep;Simplexvirus;small molecule;small molecule inhibitor;sperm cell;sperm function;Sperm Motility;success;targeted delivery;Technology;Testing;Topical application;Translations;transmission process;Ulcer;unintended pregnancy;uptake;User Compliance;Vaccines;Vagina;Vaginal delivery procedure;vaginal fluid;Vaginal Gel;Vaginal Ring;Viral;viral transmission;Virus;Woman;zygote

PROJECT_TITLE: A Novel, Multi-compartment Intravaginal Ring for Prevention of Genital Herpes and Unintended Pregnancy

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: Aging;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Modified Public Health Relevance Section   Childhood obesity continues to rise at an alarming rate “making it one of the most common pediatric chronic diseases in the US”. In children, excess fat on the thorax exerts an unfavorable burden on the respiratory system, particularly during exercise, reducing lung function, exercise tolerance, and provoking exertional breathlessness. However, it is unknown if an increase in obesity with aging worsens respiratory function, exercise tolerance, or dyspnea on exertion (DOE). To answer this question, we will re-examine body composition, lung function, exercise tolerance, and DOE in children with and without obesity who were originally studied as 8–12-year-olds; these results will have broad mechanistic relevance to our understanding of the effects of worsening obesity as children age.

PI_NAMEs: BABB, TONY G (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 12 year old;Adolescence;Age;Aging;Body Composition;boys;Breathing;cardiorespiratory fitness;Characteristics;Chest;Child;Childhood;Chronic Disease;cohort;Dyspnea;emerging adult;Ergometry;Exercise;Exercise Tolerance;Exertion;Fatty acid glycerol esters;Functional Residual Capacity;Gases;girls;Grant;Growth;Impairment;lung health;lung volume;Measures;novel;Obesity;obesity in children;Participant;Perception;Physical activity;Physical Fitness;Physiological;public health relevance;pulmonary function;Reporting;Research;respiratory;Respiratory Mechanics;Respiratory physiology;Respiratory System;Rest;Sex Differences;Testing;Weight;Work

PROJECT_TITLE: Respiratory Effects of Obesity in Children: Longitudinal Consequences after 6 Years of Aging

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Behavioral and Social Science;Comparative Effectiveness Research;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE By developing a suite of local models of syphilis epidemic calibrated for 40 cities in the United States, we aim to determine the optimal selection of existing interventions to curb new syphilis infections and to identify conditions under which emerging diagnostic and biomedical interventions are impactful and cost effective.

PI_NAMEs: KASAIE, PARASTU  (contact)

PROGRAM_OFFICER_NAME: CHUANG, ELEANORE JENNIFER

PROJECT_TERMS: Address;Adherence;Affect;Age;authority;Baltimore;Benchmarking;Birth;Budgets;Calibration;Caring;Cities;Clinic;Clinical;co-infection;Collaborations;Community Health;Congenital Syphilis;Contact Tracing;cost;cost effective;cost effectiveness;cost efficient;cost per quality-adjusted life year;Counseling;Data;Decision Making;Demographic Factors;Detection;Development;Diagnosis;Diagnostic;Doxycycline;economic impact;Economic Models;Epidemic;epidemiological model;Epidemiology;ethnic disparity;ethnic minority;Ethnic Origin;evidence base;experience;Face;Feedback;Fingers;Formulation;Frequencies;Future;Geography;Goals;Health;health disparity;Health Policy;Health Resources;Heterosexuals;HIV;Home;home test;improved;Incidence;incremental cost;Infection;Infection Control;infectious disease model;innovation;interactive visualization;Intervention;Investments;male;Marketing;mathematical model;men who have sex with men;Modeling;models and simulation;neglect;New York;New York City;novel;novel diagnostics;peer;point of care;Policies;Policy Maker;Policy Making;Population;Pregnant Women;Prevention;Prevention strategy;Preventive;preventive intervention;Prophylactic treatment;Public Health;Race;racial disparity;racial minority;randomized trial;Recommendation;Research;Risk;sample collection;scale up;Serology test;sex;sexual minority;Sexually Transmitted Diseases;simulation;social health determinants;Subgroup;Suggestion;Syphilis;Syphilis Serodiagnosis;syphilis vaccine;Testing;Time;tool;Translating;Translations;transmission process;trend;United States;United States Department of Health;urban area;user-friendly;Vaccines;Walking

PROJECT_TITLE: Translating Evidence into Action: Novel modeling approaches to end the syphilis epidemic in the U.S.


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: Project Narrative Positron emission tomography (PET) is a widely used imaging modality in oncology studies. This project aims to develop advanced image reconstruction and motion correction methods to improve 68Ga- DOTATATE and 68Ga-PSMA-11 PET image quality. Success of this project can enable better diagnosis and treatment managements of neuroendocrine tumors and prostate cancer.

PI_NAMEs: GONG, KUANG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Address;Adopted;attenuation;Breathing;cancer cell;Cancer Patient;Cine CT;Clinic;Clinical Data;Data;Data Set;deep learning;Detection;Diagnosis;Diagnostic;Diffusion;Disease;Disease Management;Distant Metastasis;Dose;Dose Limiting;Early Diagnosis;Effectiveness;empowerment;Evaluation;flexibility;fluorodeoxyglucose;FOLH1 gene;Gallium;Goals;Half-Life;Image;image reconstruction;imaging modality;Imaging Techniques;improved;Incidence;Indolent;Injections;kinetic model;Label;Learning;Lesion;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;men;Methods;Modeling;Monitor;Morphologic artifacts;Motion;Neuroendocrine Tumors;Noise;novel;Oncology;Organ;Outcome;overexpression;parametric imaging;Patients;Performance;Phase;Positron;Positron-Emission Tomography;Primary Neoplasm;Probability;Property;prospective;Prostate Cancer therapy;Radiation exposure;radiologist;Reader;reconstruction;research clinical testing;respiratory;Scanning;Selection for Treatments;Sensitivity and Specificity;sex as a biological variable;simulation;Solid;Staging;Structure;success;supervised learning;Time;Tracer;Training;tumor;Uncertainty;United States;whole body imaging;X-Ray Computed Tomography

PROJECT_TITLE: Deep Learning Methods for Improving Gallium 68-Based PET Imaging

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Infant brain development is associated with precisely timed epochs of high regional ‘plasticity’, time windows in which interventions can have substantial and life-long impact on the developing brain. The goal of this study is to characterize mechanisms of human neonatal plasticity and measure how interventions influence highly plastic brain regions. The results of this study will be useful in targeting specific interventions to specific brain regions when they are most plastic, thereby reducing psychiatric risk by optimizing brain development.

PI_NAMEs: SYLVESTER, CHAD MICHAEL (contact)

PROGRAM_OFFICER_NAME: ZEHR, JULIA L

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Animal Model;Anxiety;Attention;Birth;Body part;Brain;Brain region;Child;Clinical;Cognitive;comparison control;Data;Data Set;Development;disorder risk;Emotions;Exposure to;foot;Frequencies;Functional Magnetic Resonance Imaging;Goals;Hand;high risk infant;high risk population;Hour;Image;Impairment;improved outcome;Individual;infancy;Infant;Intervention;Language;Learning;Life;Link;Magnetic Resonance Imaging;Maps;Massage;Measurement;Measures;Mental Depression;Mental disorders;Modeling;Neonatal;neonatal brain;neonatal human;neonatal period;neonate;neurodevelopment;neuromechanism;Neuronal Plasticity;Oral cavity;Pattern;personalized predictions;postnatal;Predisposition;prevent;Prevention strategy;Preventive measure;Public Health;response;Rest;Risk;Risk Reduction;Sensory;sensory input;sensory system;Social Interaction;Testing;theories;Time;Training;Vision;Work;Youth

PROJECT_TITLE: Individualized Mechanisms of Neural Plasticity and Response to Interventions in Neonates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]


NIH_SPENDING_CATS: Bioengineering;Pediatric

ORG_DEPT: BIOCHEMISTRY

PHR: Shape is critical for the proper functioning of most tissues and organs, and the ability to understand or manipulate the outcome of tissue morphogenesis has implications for both embryonic development and regenerative medicine. This project examines the mechanical properties of tissues and the forces driving morphogenesis, which is essential for understanding animal development.

PI_NAMEs: DOUBROVINSKI, KONSTANTIN  (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Affect;Animal Organ;animal tissue;Animals;Apical;Automobile Driving;Behavior;Biological Models;Biology;Biophysical Process;biophysical properties;biophysical techniques;Biophysics;cantilever;cell cortex;cell motility;Cell Proliferation;Cells;Computer Models;Control Animal;Cytoplasm;Cytoskeleton;Data;Development;Developmental Biology;driving force;Drosophila genus;Drug or chemical Tissue Distribution;Elasticity;Embryo;embryo tissue;Embryonic Development;Epithelium;Evaluation;Event;experimental study;Gastrula;gastrulation;gene network;Generations;Genes;Goals;in silico;Knowledge;Lateral;Magnetism;Maps;Measurement;Measures;mechanical properties;Mechanics;Membrane;Membrane Lipids;Memory;Methods;Microscopic;Modeling;Molecular;Morphogenesis;Morphology;mutant;Myosin ATPase;novel;Organ;Organism;Outcome;Pathway interactions;Phenotype;physical property;Physics;predictive modeling;Process;Property;Proteins;Regenerative Medicine;Resolution;response;RNA Interference;Shapes;Spatial Distribution;Specific qualifier value;System;Techniques;Testing;Time;Tissues;Viscosity;Work

PROJECT_TITLE: Physical aspects of Drosophila Gastrulation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Genetics;Nutrition

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: 8. Project Narrative Copper, because of its function as a redox cofactor and its prevalence in enzymes that catalyze reactions with oxygen (O2) or oxygenated substrates, is an essential micronutrient for most aerobic organisms, and hence for human health. Organisms sense nutritional Cu deficiency and respond by turning on a suite of genes, which in Chlamydomonas is dependent on a transcription factor, CRR1, to facilitate copper economy and copper- dependent metabolism. CRR1 is degraded and economy measures are turned off in copper-replete cells. In this project, the investigators will dissect the signaling pathway that responds to copper supply, leading potentially to the discovery of a copper sensor and a mechanistic understanding of the connection between copper-deficiency and hypoxia.

PI_NAMEs: MERCHANT, SABEEHA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: 26S proteasome;Aerobic;Affinity;Algae;Animals;Binding;Bioenergetics;Biology;Cells;Chemistry;Chlamydomonas;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;cofactor;Complex;Copper;Cullin Proteins;cytochrome c oxidase;Cytochromes c6;Data;Development;Enabling Factors;Enzymes;Eukaryota;F-Box Proteins;Family;Feedback;gain of function;Genes;genetic analysis;Genetic Screening;Half-Life;Health;heme a;heme biosynthesis;Hemeproteins;Homeostasis;Human;hypocupremia;Hypoxia;Immunofluorescence Immunologic;Immunoprecipitation;in vitro testing;Individual;Iron;knowledge base;Life;Location;Maintenance;Malnutrition;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Micronutrients;model organism;Modeling;Modification;Monitor;multicatalytic endopeptidase complex;mutant;Mutation;Mutation Analysis;Nutrient;nutrition;Nutritional;operation;Organism;oxidation;Oxidation-Reduction;Oxygen;Pathway interactions;Photosynthesis;Physiological;Planets;Plants;Plastocyanin;Post-Transcriptional Regulation;Post-Translational Protein Processing;Prevalence;Property;Proteins;Proteomics;Reaction;Regulation;Regulon;Reporter;Research Personnel;Respiration;response;Response Elements;sensor;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;Solubility;Supplementation;Testing;Thylakoid Membranes;tool;transcription factor;Transcriptional Activation;Trees;ubiquitin-protein ligase;uptake;Work;Zinc deficiency

PROJECT_TITLE: Nutritional Cu Signaling and Homeostasis

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative This study addresses efforts to improve academic, economic, and health outcomes by preventing reading difficulties via phonological awareness intervention. The study aligns with NICHD CBDD priorities to conduct basic and translational research that optimizes interventions and thereby prevents negative public health outcomes. Specifically, our findings will inform the content, timing, and goals of phonological awareness intervention to increase effectiveness and efficiency.

PI_NAMEs: PHILLIPS, BETH ;PIASTA, SHAYNE B. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;American;Awareness;Basic Science;Child;Child Development;Child Support;Clupeidae;COVID-19;Data;Development;Disparity;Economics;Educational process of instructing;Effectiveness;Equation;Ethnic Origin;evidence base;Exhibits;experience;Funding;Goals;Health;improved;Individual;Inequity;Instruction;Intervention;kindergarten;Knowledge;Language;Learning;learning materials;Linguistics;literacy;marginalized population;National Institute of Child Health and Human Development;Nursery Schools;Outcome;peer;phonological awareness;phonology;Poverty;prevent;Prevention;Process;Professional Education;Public Health;Race;Randomized, Controlled Trials;Reading;reading difficulties;Recommendation;Research;Resources;Science;Scientist;screening;skills;Socioeconomic Status;Speech Sound;spelling;Standardization;Testing;therapy design;Time;Translational Research;Uncertainty;Variant;X Inactivation

PROJECT_TITLE: Optimizing early phonological awareness instruction to support reading and spelling acquisition

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: The proposed research is relevant to public health because it represents a new focus on zinc as a regulator of processes that sperm undergo between mating and fertilization. This aligns with NICHD’s mission, which pertains to understanding the basic biology of fertilization to build the foundation needed for the development of innovative fertility therapies.

PI_NAMEs: CARLSON, ANNE E (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Adenylate Cyclase;Bicarbonates;Biochemistry;Biology;Body part;CatSper;Cell membrane;Computer Assisted;Contraceptive methods;Cytoplasm;Data;Development;Diethyl Pyrocarbonate;egg;Electrophysiology (science);Endowment;Enzymes;Event;Excision;Exhibits;experimental study;extracellular;Family;Family suidae;Fertility;Fertilization;Fluorescence;Fluorometry;FluoZin-3;Foundations;Homeostasis;Human;Human body;In Vitro;in vivo;Incubated;Infertility;infertility treatment;innovation;insight;Knowledge;Link;Male Infertility;Mass Spectrum Analysis;Mediating;meter;Mission;Molecular;Motility;Mus;National Institute of Child Health and Human Development;novel strategies;Partner in relationship;Pattern;Penetration;Physiology;Play;prevent;Process;Property;Proteins;Proteomics;Public Health;Publishing;Recombinants;Regulation;reproductive success;Research;Role;Route;Seminal;Seminal fluid;Signal Transduction;Site;sperm analysis;sperm cell;Sperm Motility;Sperm Penetration;Swimming;Testing;Time;Trace metal;uptake;Zinc;Zona Pellucida;zygote

PROJECT_TITLE: Molecular Determinants of Zinc Regulation of Mammalian Sperm

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Suicide is the second leading cause of death among US youth and more research is needed on factors that contribute to risk and resilience to suicide attempts in adolescence. Environmental stress exposures increase risk of suicidal behavior, yet measuring environmental risk is a major challenge for research due to the complex dynamic structure of environment. In this proposal we will use multimodal longitudinal data on thousands of adolescents (i) to develop reproducible methods that quantify environmental risk in multiple cohorts globally; (ii) to better understand disparities in environmental risk and factors that confer resilience in high-risk youth; and (iii) to study biological processes through which environmental stress increases risk of suicide attempts.

PI_NAMEs: BARZILAY, RAN  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Adolescence;Adolescent;adolescent mental health;Adolescent Risk Behavior;Age;allostatic load;Biological;Biological Process;Biology;Blood Glucose;Body mass index;Brain;Cause of Death;Childhood;Classification;Clinical;clinical risk;clinically relevant;cognitive development;cohort;Complex;cyberbullying;Data;dimension reduction;Discrimination;Disparity;Distal;Ecosystem;emotion regulation;Environment;Environmental Exposure;Environmental Monitoring;Environmental Risk Factor;environmental stressor;Ethnic Origin;Etiology;experience;Exposure to;Family;follow-up;Foundations;Future;Goals;health disparity;Health Surveys;Heterogeneity;high risk;Household;improved;Individual;Intervention;large scale data;Life;lifestyle factors;Link;Maps;Measures;Mediating;Mental Health;Methods;Mexican;Minority Groups;Modeling;multimodality;multiple omics;National Institute of Mental Health;non-genomic;novel;Outcome;Pathway interactions;Pediatric Hospitals;peer;Philadelphia;physical conditioning;Physiological;Population Heterogeneity;preadolescence;Predisposition;prevent;Problem Solving;prospective;psychobiologic;psychologic;Psychopathology;Race;Reproducibility;Research;resilience;resilience factor;response;Risk;Risk Factors;Role;Running;Sampling;Schools;sexual minority;skills;Skin;Statistical Methods;Stress;Structure;Subgroup;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;Surveys;System;Testing;theories;Time;tool;translational impact;Trauma;Weight;Work;Youth

PROJECT_TITLE: The Role of the Exposome and Allostatic Load in Risk and Resilience to Youth Suicide Attempts

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Measuring proteins in blood samples or tissue biopsies collected from patients participating in cancer clinical trials is essential to understand the effect of promising new treatments on the patient’s body and tumor. These measurements are critical for helping us to determine the best dose and treatment schedule for new cancer drugs, which are important for maximizing treatment success and minimizing side effects or toxicity. Unfortunately, current technological limitations hamper our ability to measure many proteins important to cancer treatment, and our team is working to solve this problem by translating novel technologies to overcome these limitations and thereby facilitate more efficient development of new therapies and improved abilities to select patients for personalized oncology approaches.

PI_NAMEs: PAULOVICH, AMANDA G (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Address;Affect;Aftercare;Antibodies;Antibody Specificity;Antineoplastic Agents;Biological Assay;Biological Process;Biological Products;Biopsy;Blood;Blood specimen;Calibration;Cancer Center;cancer clinical trial;cancer therapy;Clinical;clinical translation;Clinical Trials;Collaborations;Collection;commercialization;Complex;Consumption;Correlative Study;Data;design;Development;DNA;DNA analysis;DNA Damage;dosage;Dose;early phase clinical trial;Environment;Enzyme-Linked Immunosorbent Assay;evidence base;Funding;Genomics;Goals;Heterogeneity;Human;immune activation;Immunoassay;Immunohistochemistry;improved;Incubated;industry partner;interest;intervention effect;kinase inhibitor;laboratory manuals;Letters;Licensing;Mass Spectrum Analysis;Measurement;Measures;Medicine;Methodology;Methods;multiple reaction monitoring;new technology;next generation;Noise;novel;novel anticancer drug;novel therapeutics;Patient Participation;patient population;Patient Selection;Patients;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacodynamics;Phase;Positioning Attribute;Post-Translational Protein Processing;precision oncology;Procedures;Process;Progress Reports;prospective;Proteins;prototype;Reagent;Research;response;RNA;Role;Sampling;Schedule;side effect;Signal Transduction;Source;Standardization;Stress Tests;success;targeted treatment;Technology;Therapeutic;therapeutic target;Time;Tissue Sample;Tissues;Toxic effect;Translating;Translations;treatment effect;Treatment Protocols;Tube;tumor;Validation;Variant;Western Blotting;Work

PROJECT_TITLE: Clinical translation of a NexGen platform for quantifying protein networks in human biospecimens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE School Based Health Centers are an important setting to improve health equity and health outcomes. Too few people are vaccinated for the human papillomavirus (HPV), which can prevent tens of thousands of deaths from cancer each year. Our program will evaluate a multilevel intervention to increase HPV vaccination and the use of School Based Health Centers for primary and preventive care.

PI_NAMEs: PETRIK, AMANDA F. (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Accounting;Address;Adolescent;Age;age group;animation;Anogenital cancer;Awareness;Behavior;behavioral health;Cancer Burden;cancer prevention;Caregivers;Caring;Cessation of life;Characteristics;Child;Clinic;Collaborations;collaborative environment;Communication;Communities;community engagement;community organizations;comparative;Comprehensive Health Care;Consent;County;COVID-19;design;Disparity;Education;Educational workshop;effectiveness evaluation;effectiveness testing;Eligibility Determination;Enrollment;Ensure;evidence base;experience;Feedback;flu;Health;health care availability;health care service;health equity;Healthcare;HPV vaccine acceptance;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation science;improved;Individual;innovation;Intervention;Intervention Studies;Interview;Language;Laws;Link;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mediator;Medical;medically underserved;Meningitis;Mental Health;Methods;Neighborhood Health Center;Oregon;Outcome;Parents;Patients;peer;Persons;physical conditioning;Population;prevent;Preventive care;Preventive healthcare;Primary Care;primary care clinic;primary health center;programs;Provider;Recommendation;Research;Research Design;satisfaction;school based health center;School-Age Population;Schools;Scientist;Series;Services;Spanish/English;Students;Subgroup;support network;tailored messaging;Text;Text Messaging;Translations;United States;uptake;Vaccination;vaccine acceptance;Vaccinee;Vaccines;young adult;Youth

PROJECT_TITLE: Multilevel Peer-to-Peer Education Program to Increase HPV Vaccinations and Wellness in School Based Health Centers (PEER)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: The proposed research will determine how the genomic RNA of MRV becomes detectable by host cells. We will determine how virus entry events influence exposure of RNA, define how accumulation of newly synthesized RNA is controlled by the µ1 outer capsid protein and define a previously unidentified role for RNautophagy in controlling viral RNA turnover.

PI_NAMEs: DANTHI, PRANAV  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acids;Affect;bat-borne;Biochemical;Biological;Bluetongue virus;Capsid;Capsid Proteins;Cathepsin L;Cathepsins;Cathepsins B;Celiac Disease;Cell Culture Techniques;Cell Death;Cell Death Induction;Cells;Cessation of life;Cryoelectron Microscopy;Cytoplasm;Data;Degradation Pathway;Detection;Double Stranded RNA Virus;Double-Stranded RNA;Endosomes;Engineering;Enzymes;Event;Experimental Models;experimental study;Exposure to;Family;follow-up;Genetic Transcription;Genome;genomic RNA;Genomics;Immune;Immune response;in vivo;Infection;Innate Immune Response;Interferons;knock-down;Lysosomes;Mammalian Orthoreovirus;Mediating;Membrane;Messenger RNA;Molecular;mRNA capping;mutant;Oncolytic;particle;particle exposure;pathogen;pathogenic virus;Pathway interactions;Pattern;Penetration;Peptide Hydrolases;Predisposition;Process;Production;programs;Property;Protein Biosynthesis;Proteins;Publishing;Reovirus;Reovirus Infections;Research;response;RNA;RNA chemical synthesis;RNA Degradation;RNA Stability;RNA Transport;Role;Rotavirus;sensor;Signal Transduction;Structure;Structure-Activity Relationship;Translating;uptake;vaccine platform;vector;Viral;viral genomics;Viral Proteins;viral RNA;Virion;Virus;Virus Assembly;Virus Diseases;Virus Replication;Work;Zoonoses

PROJECT_TITLE: Regulating the Detection of Reovirus Infection

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Clinical Research;Genetics;Health Services;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: The University of Alabama at Birmingham UAB Undiagnosed Diseases Program (UAB UDP) provides diagnostic assessments for children and adults with chronic undiagnosed conditions. It is currently a Diagnostic Center of Excellence in the Undiagnosed Diseases Network (UDN). This proposal describes numerous innovations to the UAB UDP, including increased use of telemedicine and a “genome-first” diagnostic approach, the inclusion of basic scientists in a set of diagnostic teams, collaboration with a federally qualified health center to increase diversity of patients seen, and incorporation of a set of bioinformatic and AI-powered tools, all aimed to increase patient access and diversity, as well as to improve diagnostic success rates and turnaround times.

PI_NAMEs: KORF, BRUCE R (contact)

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: Acceleration;accurate diagnosis;Adult;Affect;Alabama;Algorithms;Appointment;Area;Artificial Intelligence;artificial intelligence method;artificial intelligence model;Awareness;Bioinformatics;Biotechnology;Caregivers;Caring;Charge;Child;Childhood;Chronic;Clinical;Collaborations;Communication;Communities;Community Health;community partnership;Complex;Computational Biology;Data;data sharing;deep learning;Diagnosis;diagnosis standard;Diagnostic;Diagnostic Services;diagnostic strategy;diagnostic value;Differential Diagnosis;disability;Disease;Enrollment;Evaluation;explainable artificial intelligence;Faith-based organization;falls;Federally Qualified Health Center;Fee-for-Service Plans;Feedback;Genetic;genetic disorder diagnosis;genetic testing;Genome;genome analysis;genome sequencing;Genomics;Health;Health Insurance Portability and Accountability Act;Health Personnel;imaging study;Immunologics;improved;Inflammatory;informant;Informatics;Informed Consent;Infrastructure;innovation;Institutional Review Boards;Insurance;Interview;Investigation;Laboratories;Laboratory Study;large language model;Location;Medical;Medical Records;Medicine;meetings;Metabolic Diseases;Modernization;Molecular;Natural Language Processing;Nerve Degeneration;neuromuscular;Nurse Practitioners;patient engagement;Patient Selection;Patient-Focused Outcomes;Patients;personalized diagnostics;Persons;phenotypic data;Physicians;Process;Program Evaluation;programs;Provider;provider-level barriers;Qualifying;Rare Diseases;research clinical testing;Scientist;Secure;Services;Site;Specialist;Speed;success;symposium;System;Telemedicine;Test Result;Testing;Time;tool;Training;Universities;Variant;Visit;whole genome;Work

PROJECT_TITLE: Increasing Diversity, Diagnostic Yield, and Efficiency in Clinical Evaluations of Rare Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-W (21)]


ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Abnormal healing of blood vessels leads to narrowing and failure in half of all procedures for vascular blockages. Currently, balloons coated with medications to prevent this problem are delivered from inside the vessel, yet significant drug is washed off by the bloodstream and delivery to the vessel target remains poor. This project will investigate a chambered retrievable stent to reduce drug loss in the bloodstream, allow use of higher dose medications, improve exposure time to the drug, and may improve the treatment of recurrent vascular narrowing.

PI_NAMEs: TILLMAN, BRYAN W. (contact);YAZDANI, SAAMI K

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Aftercare;Anatomy;Angioplasty;antiproliferative drugs;Area;Arteries;aspirate;Biological Assay;Bioreactors;Blood Circulation;Blood Vessels;Bypass;Catheters;Cell Proliferation;chemotherapy;Circulation;cost;design;Distal;Dose;Drug Delivery Systems;Drug Exposure;drug isolation;Drug Kinetics;drug standard;Drug Targeting;Effectiveness;Embolism;Endothelial Cells;Endothelium;Excision;Exhibits;Exposure to;Failure;Femur;Genes;healing;Histologic;Human;Hyperplasia;immune modulating agents;Impaired healing;Implant;improved;improved outcome;in vivo;Incubated;Infusion procedures;Inguinal region;Intervention;Ischemia;Life;limb loss;Limb structure;Liquid substance;Location;Mass Spectrum Analysis;Medical;Methods;minimally invasive;Modeling;Myocardial Ischemia;Nature;Needlestick Injuries;novel;novel therapeutics;Operative Surgical Procedures;Paclitaxel;Pathology;Perfusion;Pharmaceutical Preparations;Pharmacotherapy;Polymers;porcine model;preservation;prevent;Procedures;Proliferating;Recovery;Recurrence;restenosis;Risk;Risk Reduction;seal;Shapes;Smooth Muscle;Specific qualifier value;Specimen;Stents;Stroke;Surgical incisions;System;systemic toxicity;Testing;Therapeutic;Thrombosis;Time;Toxic effect;Translating;vascular bed;vasoactive agent;vector

PROJECT_TITLE: A Retrievable, Chambered Stentgraft to Achieve Localized, High Intensity Drug Delivery for Treatment of Vascular Restenosis

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE Idiopathic Pulmonary Fibrosis (IPF) is a devastating rare lung disease of older adults marked by progressive respiratory failure for which there remains a significant unmet need for effective medical therapies. Lung epithelial cell dysfunction associated with disrupted cell quality control including an exuberant unfolded protein response (UPR)(i.e. endoplasmic reticulum (ER) stress) and/or mitochondrial dysfunction has emerged as an important causal contributor to lung fibrosis. This proposal will leverage novel mouse models expressing mutations in the Surfactant Protein C (SFTPC) gene that are associated with human lung fibrosis and will use them characterize the molecular and cellular mechanisms which contribute to epithelial cell dysfunction, emergence of pathological cell states, and the ensuing fibrotic response.

PI_NAMEs: BEERS, MICHAEL FRANCIS (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Adult;Affect;Aging;alveolar epithelium;Architecture;arm;ATF6 gene;Autophagocytosis;Bioenergetics;Biogenesis;Biological Models;Cell Reprogramming;Cells;Cellular Metabolic Process;cellular targeting;Cessation of life;Chronic;Cicatrix;Consensus;Coupled;Data;Distal;Elements;endophenotype;Endoplasmic Reticulum;endoplasmic reticulum stress;epigenomics;Epithelial Cells;Epithelium;Equilibrium;Equipoise;Event;fibrogenesis;Fibrosis;fibrotic lung;Functional disorder;Funding;Gases;Gene Mutation;Generations;Genes;Genetic;Genetic Transcription;genetic variant;Glycolysis;Human;human disease;Hypoxemic Respiratory Failure;idiopathic pulmonary fibrosis;Impairment;In Vitro;in vitro Model;in vivo;injury and repair;Interstitial Lung Diseases;Knock-in Mouse;Lung;Lung Diseases;Mediating;Mediator;Medical;Membrane;Metabolic;Metabolic Control;Metabolism;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Molecular Profiling;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutation;nintedanib;novel;novel therapeutics;older adult;Outcome;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;pharmacologic;Phenotype;Phosphotransferases;Physiology;Pirfenidone;Population;pre-clinical;Pre-Clinical Model;programs;Progress Reports;Protein Isoforms;Proteins;proteostasis;prototype;Publishing;Pulmonary Fibrosis;Pulmonary Surfactant-Associated Protein C;Quality Control;Refractory;repaired;Respiration;Respiratory Failure;response;Role;Secondary to;Seminal;Signal Pathway;Signal Transduction;stem cell function;Subgroup;Support System;Testing;Therapeutic;Tissues;tool;transcriptome;transcriptomics;Transitional Cell;Translations;Transplantation;Work

PROJECT_TITLE: Alveolar Epithelial Cell Dysfunction in Pulmonary Fibrosis: Leveraging SFTPC Mutations for Discovery of Molecular and Cellular Targets

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Immunotherapy;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE Peritoneal metastases have been considered a terminal condition for the majority of patients, but emerging evidence of immune advantages associated with intraperitoneal administration presents opportunities to advance novel therapeutics for these cancers. Intraperitoneal delivery of immunogenic mesoporous silica nanoparticles leads to rapid internalization by free and spheroid-associated myeloid cells with subsequent trafficking to tumor implants. Completion of this project will facilitate clinical translation of nanotechnology platforms for immune therapy of patients with ovarian cancer with broader application to other tumors associated with peritoneal metastases.

PI_NAMEs: SERDA, RITA ELENA (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acoustics;Agonist;Alleles;anti-cancer;Antibodies;Ascites;B-Lymphocytes;Biological Assay;Blood;cancer cell;cancer immunotherapy;Cancer Model;Cancer Patient;Cell Line;Cells;cellular targeting;Clinical;Clinical Oncology;clinical translation;Clinical Trials;Colon Carcinoma;Colorectal Cancer;comparison control;Complex;Confocal Microscopy;cytokine;cytotoxicity;Diagnosis;Disease;Dose;Electron Microscopy;Flow Cytometry;Hematogenous Spread;Hematology;Hemolysis;Histopathology;HLA-A gene;Human;Human Biology;humanized mouse;IgG1;Immune;immune activation;Immune checkpoint inhibitor;immunogenic;Immunologic Markers;Immunotherapy;Implant;In Vitro;Injections;intraperitoneal;Intravenous;intravital microscopy;ITGAM gene;Leucocytic infiltrate;leukocyte activation;Liver;Lymphoid;Magnetic nanoparticles;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Modeling;mouse model;Mus;Myeloid Cells;Myeloid-derived suppressor cells;nano;Nanoimmunotherapy;nanomedicine;nanoparticle;nanotechnology platform;Neoplasm Metastasis;neoplastic cell;neutralizing antibody;novel strategies;novel therapeutics;Patients;Peritoneal;Pharmacology;Poly I-C;pre-clinical;preclinical study;Property;Qualifying;Research;resiquimod;Route;Sampling;Serous;Serum;Silicon Dioxide;spheroids;subcutaneous;T-Lymphocyte;tertiary lymphoid organ;Testing;Tissues;Toll-like receptors;Toxic effect;Toxicology;trafficking;Treatment Efficacy;treatment response;tumor;Tumor Burden;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor Tissue;Validation;Variant;Woman;Work

PROJECT_TITLE: TLR Agonist Nano-Immune Therapy for Peritoneal Metastases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-U (55)]