PHR: Narrative The central goal of our translational research is to get the most up to date laboratory research and the most current clinical experience to talk productively to each other, for the most rapid and efficient progress toward controlling and eliminating breast cancer. Thus we have designed this career enhancement program to expose young researchers to the full range of the breast cancer research experience in a vigorously translational environment, whatever their initial training was, as they move towards research independence.

PI_NAMEs: FUQUA, SUZANNE AW (contact)

PROJECT_TERMS: Agreement;anti-cancer research;Area;Award;Breast;Cancer Research Project;candidate selection;career;Clinical;clinical investigation;clinical practice;course development;design;Development;Doctor of Philosophy;Environment;experience;Exposure to;Faculty;Fellowship;Goals;Grant;Individual;Laboratories;Laboratory Research;Malignant Breast Neoplasm;Mentors;Positioning Attribute;Process;Productivity;programs;Research;Research Personnel;Research Project Grants;Role;skills;Time;Training;Translational Research

PROJECT_TITLE: Career Enhancement Program (CEP)


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: COLUMBIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PI_NAMEs: GREEN, JONATHAN A (contact)

PROJECT_TERMS: Address;Alleles;Animal Experiments;Animal Model;Animal Testing;Animals;Basic Science;Biological;Breeding;Cells;clinical application;Clinical Trials;cohort;Communication;Cryopreservation;Data;design;Development;disease model;Drug Kinetics;Ensure;Evaluation;Evolution;expectation;Family suidae;Genes;Genome;genome editing;Human;human disease;Individual;Methods;Mission;Missouri;Modeling;Monitor;Movement;novel;Pharmacodynamics;Phenotype;Physiological;porcine model;pre-clinical;pre-clinical research;preservation;Procedures;programs;Reagent;reagent testing;Reporter;Reporting;Research Personnel;Resources;Role;Safety;Services;somatic cell gene editing;Standardization;Technology;Testing;testing services;Therapeutic;Tissues;Toxic effect;Translating;Translational Research;Translations;Universities;Work

PROJECT_TITLE: Genome Editing and Biological Effects Testing: Somatic Cell Gene Editing Testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V]


PI_NAMEs: PRATHER, RANDALL S (contact)

PROJECT_TERMS: Alleles;Animal Experiments;Animal Testing;Animals;biosafety level 2 facility;biosecurity;Breeding;Cells;cohort;Communities;Consultations;Cryopreservation;Data;detection sensitivity;disease model;efficacy evaluation;Ensure;experience;Family suidae;Fee-for-Service Plans;Future;Genes;Genetic;genetic resource;genome editing;Goals;Human;Income;Individual;Maintenance;Methods;Modeling;Nature;new technology;novel;pathogen;Patients;porcine model;preservation;Production;programs;Protocols documentation;Reagent;reduce symptoms;Reporter;Research;Resources;Role;Sampling;sex;Slide;somatic cell gene editing;System;Technology;Testing;Therapeutic;Tissues;tool;Validation;Work

PROJECT_TITLE: Resource: Swine Somatic Cell Gene Editing Testing Center


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Collective cell migration is a process by which cells move in concert with each other that occurs across all stages of human development, as well as in tissue repair and various pathologies. The proposed work seeks to understand the mechanisms that drive collective cell movement. New tools will be developed to activate, monitor, and analyze a critical molecule involved in collective migration, thereby enabling the identification of pathways and cellular behaviors that can be manipulated to control this process in pathological conditions.

PI_NAMEs: KREEGER, PAMELA K (contact);MASTERS, KRISTYN S

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actins;Biochemical;Biocompatible Materials;Biological Assay;Biophysical Process;biophysical tools;Biophysics;Breast Cancer Cell;cell behavior;Cell model;cell motility;Cell Physiology;Cells;Cellular Structures;Chemicals;Chronic;Collaborations;Coupling;Cues;Cytoskeleton;Decision Making;EGF gene;Elements;Environment;Epidermal Growth Factor Receptor;Epithelium;Event;experimental study;Fluorescence Resonance Energy Transfer;Foundations;Genetic;Goals;Growth Factor;healing;Health;Human;Human Development;human tissue;Impairment;Individual;innovation;insight;Intercellular Junctions;Intervention;keratinocyte;Knowledge;Link;Malignant Neoplasms;Methods;migration;Molecular;Monitor;Motion;Movement;novel;optogenetics;Pathologic;Pathology;Pathway interactions;Pattern;PLC gamma1;Process;repaired;Reporter;Signal Transduction;spatiotemporal;spheroids;Stimulus;tissue repair;Tissues;tool;Traction Force Microscopy;Translating;transmission process;Travel;Work

PROJECT_TITLE: Deciphering mechanisms that drive collective cell migration


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

ORG_CITY: NEW YORK

ORG_DEPT: DENTISTRY

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE  Emerging adulthood (EA) is a developmental phase characterized by increased risk-taking behaviors including heavy episodic drinking (HED). Romantic relationship conflict may be a particularly salient social influence in EA drinking behavior and a promising target for prevention and intervention, but these associations have not yet been explored. The proposed award will support the candidate’s transition to independence in patient-oriented alcohol research and address this critical gap in the literature by examining the associations between controlled alcohol administration, conflict communication behaviors, and the psychophysiological responses that may underpin this bidirectional relationship.

PI_NAMEs: HOGAN, JASARA  (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Acute;acute stress;Address;Adolescence;Adult;Alcohol abuse;Alcohol consumption;alcohol misuse;alcohol poisoning;alcohol prevention;alcohol research;alcohol use disorder;Alcoholic Intoxication;Alcohols;Area;Arousal;Autonomic nervous system;Award;Behavior;Behavioral;binge drinking;Biological Markers;breath alcohol measurement;career;career development;Clinical Trials;Code;Communication;communication behavior;Conflict (Psychology);conflict resolution;Consult;Consumption;coping;coping mechanism;Couples;craving;Data;Data Collection;Depressed mood;design;Development;disorder risk;drinking;drinking behavior;emerging adult;emerging adulthood;emotion regulation;Emotional;Emotions;Enrollment;experience;Foundations;Frequencies;Future;Goals;Grant;Health behavior;heart rate variability;Hostility;improved;Individual;Intervention;Laboratories;Laboratory Procedures;Learning;Life;Link;Literature;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Mission;National Institute on Alcohol Abuse and Alcoholism;Nervous System Physiology;Neurobiology;novel;optimism;Participant;Pathway interactions;patient oriented;peer;Phase;Physiological;Population;Positioning Attribute;Prevention;Prevention approach;Prevention program;problem drinker;Procedures;Process;Productivity;programs;protective factors;Psychophysiology;public health priorities;Relapse;Research;Research Personnel;response;Rest;Risk Factors;Risk Taking;Role;Self Administration;Series;sexual assault;skills;social;social influence;Stressful Event;Time;Training;training opportunity;Treatment outcome;Video Recording;Writing

PROJECT_TITLE: Understanding the Associations between Romantic Relationship Conflict, Psychophysiological Responding and Alcohol Misuse among Emerging Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Replication of the DNA within our genome requires a highly orchestrated series of molecular events to propagate genetic information during cell proliferation with high fidelity, and thus to suppress the onset of diseases such as cancer. This project will combine a unique genetic strategy in the fruit fly Drosophila melanogaster with sophisticated imaging and molecular biology approaches to determine how the synthesis of histones proteins and their packaging of DNA into chromatin regulates the process and fidelity of DNA replication. Because of the high evolutionary conservation of regulators of chromatin and DNA replication, discoveries resulting from our mechanistic studies in flies will be directly applicable to humans.

PI_NAMEs: DURONIO, ROBERT J (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acetylation;Address;Anabolism;Animals;Base Pairing;Biochemical;Biological;Cell Cycle;Cell Cycle Regulation;Cell Proliferation;Cells;Chemicals;Chromatin;Chromatin Modeling;Chromosomes;Development;DNA;DNA biosynthesis;DNA Packaging;DNA sequencing;Drosophila genus;Drosophila melanogaster;Engineering;Epigenetic Process;Event;fly;Gene Cluster;Gene Expression;Genes;genetic approach;genetic information;Genetic Transcription;Genome;Health;Histones;Homeostasis;Human;Human Pathology;Image;in vivo;Individual;Location;Malignant Neoplasms;Messenger RNA;Methods;Methylation;Modification;Molecular;Molecular Biology;mRNA Precursor;Mutation;N-terminal;next generation;Nuclear;Nucleosome Core Particle;Nucleosomes;Onset of illness;Phosphorylation;Play;Poly(A) Tail;prevent;Process;Proteins;Regulation;Role;S phase;Series;stem;System;Tail;whole genome

PROJECT_TITLE: Epigenetic Control of the Cell Cycle During Animal Development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project Narrative The ODSP will develop a flexible, scalable open data science platform for the DSI-Africa consortium to find and access data, select tools and workflows and run analyses on a choice of computing environments, all through easy to use workspaces. Administration and support of the core resources and consortium activities will be coordinated by the CC. Together, the ODSP and CC will provide an infrastructure for researchers to use data science technologies to deliver cutting edge biomedical research for health, while promoting cohesion, collaborative cross-consortium activities and engagement with external stakeholders to facilitate innovation and translation.

PI_NAMEs: MULDER, NICOLA  (contact);SKELTON, MICHELLE

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: Accountability;Address;Africa;African;Agreement;Biomedical Research;cohesion;Computational Biology;Country;Data;data access;Data Analyses;data management;Data Science;Data Set;data sharing;Data Storage and Retrieval;data submission;Deposition;Development;Educational workshop;Elements;Ensure;Environment;ethical, legal, and social implication;Event;experience;flexibility;Fostering;Goals;Grant;Health;Human;Industrialization;Industry;Informatics;Infrastructure;innovation;insight;Joints;Knowledge;member;Methods;multidisciplinary;novel;open data;Organizational Efficiency;Outcome;Output;Participant;Policies;Policy Developments;preservation;Privatization;Reporting;Research;Research Personnel;Resource Informatics;Resource Sharing;Resources;Running;Science Policy;Scientist;success;Sum;Techniques;Technology;tool;tool development;Training;Training Programs;Translations;Universities;Vision;website development;Work

PROJECT_TITLE: eLwazi Open Data Science Platform and Coordinating Center

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: MULDER, NICOLA  (contact)

PROJECT_TERMS: Academia;Address;Africa;African;Authorization documentation;Automobile Driving;Bioinformatics;Catalogs;cloud platform;cohort;Complex;complex data;computing resources;Core Facility;cost;Data;data access;Data Analyses;data hub;data integration;data management;data modeling;data platform;data registry;data repository;Data Science;data science infrastructure;Data Set;data sharing;data standards;Development;diverse data;Ensure;Environment;experience;Feedback;flexibility;Fostering;Funding;Generations;Genomics;graphical user interface;Health;health application;Health Sciences;Human;indexing;Industry;industry partner;Infrastructure;innovation;International;interoperability;Knowledge;Location;low and middle-income countries;machine learning model;Maps;Measures;Metadata;Methodology;Modeling;Monitor;multiple datasets;novel;open data;Outcome;Output;outreach;outreach program;Performance;Personal Satisfaction;Population;Privatization;Procedures;Process;programs;Protocols documentation;Recommendation;Registries;Reproducibility;Research;Research Personnel;Research Support;Resources;Running;Science;Scientist;Secure;Services;Site;skills;Structure;success;support tools;System;Techniques;tool;Training;Training Programs;Translating;Universities;Vision;Visualization;web interface;Work

PROJECT_TITLE: eLwazi Open Science Data Platform for Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: CAPE COAST

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: UNIVERSITY OF CAPE COAST

PHR: Project Narrative The proposed research harnesses data science applications to establish the spatial variability in the impact of ambient PM2.5 exposure on children’s health in Sub-Saharan Africa (SSA) and further identify the explanatory and moderating factors. The proposed research is relevant as it focuses on leveraging data science tools to address a very pressing public health problem in Africa in line with the overarching goals of the DSI-Africa program. The proposed research will enhance public health data science capacity on the continent and with the findings triggering investment in air pollution control as well as policy action for addressing area and household poverty to help improve child health and survival in SSA.

PI_NAMEs: AMEGAH, ADELADZA KOFI (contact);BAINOMUGISHA, ENGINEER

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acute respiratory infection;Address;Adolescence;Adult;Africa;Africa South of the Sahara;African;Air;air monitoring;Air Pollution;air pollution control;ambient air pollution;Area;Bayesian Modeling;burden of illness;Cessation of life;Child;Child Development;Child Health;Child Malnutrition;Childhood;Cities;Complex;computer scientist;Country;Data;Data Science;Data Set;Data Sources;Demographic and Health Surveys;disability;diverse data;early life exposure;Environment;Environmental Exposure;Environmental Health;Environmental Monitoring;Epidemiologist;Excess Mortality;fine particles;Future;Ghana;Goals;Health;health data;Household;Imagery;improved;in utero;Individual;Infant Mortality;innovation;interest;Internet of Things;Investments;Knowledge;land use;Life;Machine Learning;Maps;Methods;Modeling;Monitor;multidisciplinary;Neighborhoods;Neonatal Mortality;nutrition;Outcome;Outcome Assessment;Policies;Poverty;Prevalence;programs;Province;Public Health;remote sensing;Research;Resolution;respiratory;Respiratory Tract Infections;response;Risk;Risk Factors;Role;Sanitation;sensor;Surveys;Techniques;Technology;Testing;tool;Uganda;Water;water quality

PROJECT_TITLE: Leveraging Data Science Applications to Improve Children's Environmental Health in Sub-Saharan Africa (DICE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Data Science

PI_NAMEs: SKELTON, MICHELLE  (contact)

PROJECT_TERMS: Administrator;Adopted;Africa;African;Agreement;Area;Awareness;Biotechnology;Botswana;career;Career Choice;career development;Career Mobility;Cities;Cognitive;cohort;Collaborations;Communication;Communities;community based participatory research;community engagement;Community Healthcare;Computer Models;Consultations;Country;Data;Data Collection;data repository;Data Science;Data Scientist;data sharing;Databases;Decision Making;Dedications;Development;digital;Educational Curriculum;Educational workshop;Ensure;Environment;Epidemic;Evaluation;evidence base;exhibitions;experience;Fostering;Future;Goals;Government;Guidelines;Health;Health Sciences;Healthcare Systems;Human Resources;implementation strategy;improved;Individual;Industry;innovation;Institution;Instruction;Intellectual Property;interdisciplinary collaboration;interest;International;Internships;Investments;Knowledge;Leadership;Learning;Literature;Mauritius;meetings;member;Mentors;Mentorship;Methods;Mission;Monitor;multidisciplinary;Needs Assessment;open data;outreach;Peer Review;Persons;Policies;Population;Positioning Attribute;Principal Investigator;Procedures;Process;Productivity;Program Development;programs;Progress Reports;Reporting;repository;Research;research and development;Resources;Scientist;Secure;skills;skills training;Surveys;System;Time;tool;Training;training opportunity;Training Support;Translational Research;United States National Institutes of Health;Universities;Vision;volunteer;web page;Work;working group

PROJECT_TITLE: Data Science for Health Discovery and Innovation in Africa Coordinating Centre (DS-I Africa CC)


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Cilia are linked to important human disease. There lacks a detailed structural mechanism of the cilium assembly and ciliary motility. We aim to tackle this problem by cryo‐EM, biochemistry, single‐molecule biophysics, and computational approaches.

PI_NAMEs: ZHANG, KAI JACK (contact)

PROJECT_TERMS: Address;Algae;appendage;arm;ATP Hydrolysis;Biochemistry;Biological Models;biophysical model;Biophysics;Cells;Cellular biology;Cilia;ciliopathy;Computer Models;Congenital Disorders;Cryoelectron Microscopy;Defect;Disease;disease model;Dynein ATPase;Electron Microscopy;Environment;extracellular;Flagella;Functional disorder;Future;Human;human disease;Individual;Lead;light microscopy;Link;Liquid substance;mechanical force;Methods;Modeling;Motility;Motor;Movement;Mutagenesis;Mutation;Organelles;Orthologous Gene;Patients;Primary Ciliary Dyskinesias;Proteins;Regulation;Signal Transduction;single molecule;Symptoms;System

PROJECT_TITLE: Structural basis of dynein-driven ciliary motility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetic Testing;Genetics;Health Services;Human Genome;Pediatric;Precision Medicine

ORG_CITY: SEATTLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Although the widespread adoption of clinical exome sequencing has helped identify the genetic basis of many previously unsolved Mendelian disorders, approximately 50% of individuals remain unsolved after a complete clinical workup. Long-read sequencing has the potential to identify and resolve many complex or difficult-to- identify variants such as insertions, deletions, repeat expansions, and variants within duplicated genes, but it has yet to be systematically evaluated in a clinical cohort. Here I propose a set of experiments which seek to evaluate the incremental diagnostic rate of long-read sequencing in cohorts that have had extensive but nondiagnostic clinical genetic testing and to compare long-read sequencing as a single test to a standard outpatient clinical workup.

PI_NAMEs: MILLER, DANNY ERWIN (contact)

PROGRAM_OFFICER_NAME: MILLER, BECKY

PROJECT_TERMS: Adoption;Appointment;Award;Biological Assay;Biological Process;Caring;Clinic;Clinic Visits;Clinical;clinical diagnostics;clinical practice;cohort;Collaborations;Communities;Complex;complex data;Cost Savings;Critical Illness;Data;Data Set;Data Sources;Diagnosis;Diagnostic;Diagnostic tests;Disease;disease-causing mutation;DNA Insertion Elements;DNA sequencing;Evaluation;exome;exome sequencing;experience;experimental study;Family;Funding;Gene Duplication;Gene Expression;Genetic;Genetic Diseases;genetic disorder diagnosis;genetic testing;Genetic Variation;genome sequencing;Genomic Segment;Genomics;Goals;graduate student;Health system;Healthcare Systems;human disease;human genome sequencing;imprint;Individual;Institution;interest;International;Investments;Laboratories;Medical;Medical Genetics;meetings;Mendelian disorder;Mentors;Messenger RNA;Methods;Methylation;nanopore;neonate;new technology;novel;novel therapeutics;Nucleotides;operation;Outpatients;Parents;Patients;pediatric department;Pediatric Hospitals;Persons;Postdoctoral Fellow;precision medicine;Precision therapeutics;prediction algorithm;professor;prognostic;Protein Isoforms;rare genetic disorder;Research;research clinical testing;Research Personnel;Residencies;Sensitivity and Specificity;skills;Spliced Genes;success;Technology;Testing;Time;Training;transcriptome sequencing;Universities;Variant;variant detection;Vision;Washington;whole genome;Work

PROJECT_TITLE: Long-read DNA and RNA sequencing to identify disease-causing genetic variation and streamline testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-H(70)R]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: The known dental caries pathogen Streptococcus mutans is able to survive an acidic environment and cause disease by increasing the proportion of unsaturated fatty acids in its cell membrane. The proposed research will determine the extent of this acid stress response among oral bacteria, and the mechanism by which unsaturated fatty acids protect against environmental acid stress. Results generated from this study will improve understanding of the pathogenesis of dental caries, the world’s most common chronic infectious disease, and will likely open the door to investigation of novel anti-caries therapeutics.

PI_NAMEs: BAKER, JONATHON  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: acid stress;Acids;Address;anticaries;ATP phosphohydrolase;Attention;Award;Bacteria;bacterial community;Basic Science;bioinformatics tool;biological adaptation to stress;Biological Assay;career development;Caries prevention;cariogenic bacteria;Cell membrane;Cerulenin;Chronic;combat;Communicable Diseases;Communities;community setting;Complex;Data;Data Set;demineralization;Dental caries;Dental Enamel;Dentistry;Diffusion;Disease;Ensure;Environment;environmental stressor;Enzymes;Exhibits;fatty acid biosynthesis;Fatty Acids;Flow Cytometry;fluidity;Fluorescence Microscopy;Fluorides;Funding;Gene Deletion;Genome;Goals;Health;Homologous Gene;improved;In Vitro;inhibitor;interest;Investigation;Isomerase;Lactobacillus casei;lectures;lipidomics;Lipids;Liquid Chromatography;Mass Fragmentography;Mass Spectrum Analysis;Mediating;medical schools;Membrane;Membrane Fluidity;Membrane Lipids;Membrane Proteins;Mentors;Metabolism;metabolomics;Metagenomics;metatranscriptomics;microbial;Microbial Biofilms;microbial community;Microbiology;Modeling;Modification;Molecular;Monitor;mutant;novel;novel therapeutic intervention;novel therapeutics;Oral;oral bacteria;oral biofilm;Oral cavity;Oral Examination;oral microbial community;oral microbiome;Organism;pathogen;Pathogenesis;Phase;Prevalence;prevent;Prevention strategy;Process;Production;programs;Property;Research;response;Scientist;skills;Streptococcus mutans;tandem mass spectrometry;Therapeutic;tooth surface;Training;Universities;Unsaturated Fatty Acids;Virulence

PROJECT_TITLE: Investigating Membrane Alterations as a Mechanism of Acid Tolerance in Cariogenic Bacteria

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Teenage Pregnancy;Women's Health Research

ORG_CITY: LUSAKA

ORG_COUNTRY: ZAMBIA

ORG_FIPS: ZA

ORG_NAME: CENTRE FOR INFECTIOUS DISEASE RESEARCH

PHR: Project Narrative  Zambian AGYW remain at high risk for HIV as incidence rates rose from 2010 – 2020 while decreasing in all other groups. AGYW, 15-19 year-olds are 4 times more likely to acquire HIV than their male peers, but HIV testing rates are low (45.4%), and 71.2% do not know their HIV status. PreP uptake and sustained adherence is poor. This theoretically-grounded, hypothesis-driven hybrid-trial will address critical gaps in the HIV prevention continuum for Zambian AGYW, with a long-term goal to sustain effective programs that reduce HIV/STI infections.

PI_NAMEs: BOLTON MOORE, CAROLYN  (contact);HOSEK, SYBIL

PROGRAM_OFFICER_NAME: LEE, SONIA S

PROJECT_TERMS: 18 year old;19 year old;2 arm randomized control trial;Address;Adherence;Adolescent;Adult;AIDS prevention;Area;Attention;Automobile Driving;Awareness;black women;burnout;catalyst;Chicago;Clinical;Clinical Research;Communities;community advisory board;condoms;Control Groups;cost;Coupled;design;dissemination science;Distress;effective intervention;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Ensure;evidence base;Evidence based program;Exploration, Preparation, Implementation, and Sustainment;Failure;Feedback;Feeling;Female Adolescents;Focus Groups;follow-up;Funding;Geography;Goals;Government;Health;Health Personnel;Health Promotion;Health Services;high risk;High Risk Woman;HIV;HIV Infections;HIV-infected adolescents;Hour;Human immunodeficiency virus test;Hybrids;Illinois;implementation outcomes;implementation research;implementation science;implementation strategy;Incidence;Individual;Infection;Infectious Diseases Research;informant;Intervention;Interview;Job Satisfaction;Logic;male;Medical;Mental Health;Methods;Minor;Modeling;Mothers;Occupations;Outcome;Participant;Patient Self-Report;peer;performance site;pilot test;poor health outcome;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevention service;Primary Prevention;Program Sustainability;programs;Province;Psyche structure;psychosocial;Public Health;Randomized;Research;Research Infrastructure;Resource-limited setting;Resources;Risk;Safe Sex;screening;sex;Sex Behavior;sexual risk taking;sexually active;Sexually Transmitted Diseases;social;South Africa;Specific qualifier value;stem;success;testing uptake;transmission process;treatment arm;United States;United States National Institutes of Health;Universities;uptake;Viral;working group;Workplace;young woman;Zambia

PROJECT_TITLE: ZAIMARA: Zambian Informed Motivated Aware and Responsible Adolescents and Adults


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: The University of Illinois at Chicago Center for Clinical and Translational Science (UIC CCTS) proposes to continue to be a robust and highly contributory hub in the national CTSA program that both advances and applies clinical translational research in a timely manner and expands and diversifies the clinical translational workforce. The overarching goal - and driving focus - of UIC CCTS is to improve population health, particularly among minorities and underserved populations across the lifespan. Today's health problems are complex, and addressing them requires the integrated collaborative efforts of scientists and practitioners along the translational spectrum, along with processes to overcome translational barriers. We propose a suite of programs and processes that will help accelerate the translation of scientific discoveries into practice and to overcome the challenges of addressing the complex health problems of today.

PI_NAMEs: KARNIK, NIRANJAN SUBHASH;MERMELSTEIN, ROBIN J. (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: Acceleration;Address;Automobile Driving;Basic Science;catalyst;Chicago;Clinical;Clinical and Translational Science Awards;clinical center;Clinical Research;Clinical Sciences;clinical translation;Collaborations;college;Communities;community engaged research;community engagement;Community Health;Complex;Data;Data Sources;Development;Discipline;Dissemination and Implementation;Education;Ethnic Origin;Evaluation;Foundations;Funding;Goals;graduate student;Health;Health Personnel;Health Sciences;Illinois;implementation science;improved;Individual;Industry;Informatics;informatics infrastructure;innovation;Institution;life span;member;method development;Methods;Minority Groups;Mission;Modeling;Movement;multi-site trial;multidisciplinary;multimodal data;Outcome;Patients;Persons;Policies;Policy Maker;Population;population health;Population Heterogeneity;Positioning Attribute;Postdoctoral Fellow;Process;programs;recruit;Reproducibility;Research;Resources;Science;Scientist;Site;social health determinants;Special Population;success;System;Training;Training Programs;translational barrier;translational pipeline;Translational Research;Translations;Underserved Population;United States National Institutes of Health;Universities;Vulnerable Populations;Workforce Development


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of this application is to continue our project that facilitates the research network for “Harmonization of cross-national studies of aging to the Health and Retirement Study.” This network supports the development of new international studies with harmonized HRS around the world data, maintains harmonization and data development among existing comparable HRS studies, and fosters a cross-country research agenda that can provide important insights for understanding health disparities.

PI_NAMEs: WEIR, DAVID R. (contact)

PROGRAM_OFFICER_NAME: CHATTERJI, MINKI

PROJECT_TERMS: Acceleration;Accelerometer;Achievement;Aging;Agreement;Behavior;Brazil;China;Collaborations;Communities;Comparative Study;cost;Country;Data;design;Development;Egypt;England;Exercise;experience;Family Study;Feasibility Studies;Fostering;Funding;Future;Goals;Grant;Great Britain;Health and Retirement Study;health disparity;improved;India;innovation;insight;Institution;International;Ireland;Joints;journal article;Leadership;Lebanon;Malaysia;meetings;member;Methodology;National Institute on Aging;Nature;pandemic disease;Persons;Population;Principal Investigator;Professional Organizations;R24;Recommendation;Reporting;Research;Research Personnel;Scientist;Sleep;South Africa;Subgroup;support network;Surveys;symposium;Thailand;Uruguay;virtual;web site

PROJECT_TITLE: Harmonization of Cross-National Studies of Aging to HRS (NIA)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Proteins perform critical cell functions, but they also fuel growth and proliferation, which, can lead to cancer if not carefully controlled. The goal of this research is to understand how the functions of the molecule named LARP1 change in response to its environment and how these changes influence the cell’s fundamental ability to make proteins. Our work will reveal the mechanisms of LARP1 that can be targeted for the future design of chemotherapeutics to treat these diseases.

PI_NAMEs: BERMAN, ANDREA J. (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Affect;Amino Acids;Binding;Binding Proteins;Biochemistry;Biological Models;Biology;Biophysics;Cell Physiology;Cells;Chemistry;Communication;design;Disease;Environment;Future;Gene Expression;Goals;Growth;Homeostasis;Malignant Neoplasms;Membrane Proteins;Messenger RNA;Modification;Molecular;Names;Outcome;Output;Pathway interactions;Post-Transcriptional RNA Processing;Post-Translational Protein Processing;posttranscriptional;programs;Proliferating;Protein Conformation;Proteins;Regulation;Repression;Research;response;RNA;RNA Binding;RNA Recognition Motif;RNA-Binding Proteins;Shapes;Shunt Device;Signal Pathway;Signal Transduction;structural biology;Structure;Structure-Activity Relationship;System;Therapeutic;Transcript;Translational Regulation;Translations;Work

PROJECT_TITLE: Translation regulation by molecular switch RNA-binding protein LARP1

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Children from low-income Latino backgrounds are at elevated risk for poor school readiness, which perpetuates existing health inequities. Primary care is an ideal setting to promote optimal school readiness given its frequent contact with at-risk children. The current proposal will yield important information on the effects of an innovative family wellness program in primary care and in turn will provide insight on how primary care can promote whole person 360-degree care for at-risk children and their families.

PI_NAMEs: JIMENEZ, MANUEL E (contact)

PROGRAM_OFFICER_NAME: SAGATOV, ROBYN

PROJECT_TITLE: Ready and Healthy for Kindergarten: A Primary Care Innovation to Promote a 360-degree View of Child Health

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SALT LAKE CITY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The results of this research will provide quantitative characterization of anatomical form and its relationship with function in patients that undergo ankle fusion surgery to treat ankle osteoarthritis. These data should help surgeons to better address deformities at the time of ankle fusion surgery, which could in turn improve clinical outcomes and reduce the likelihood that patients will develop secondary subtalar arthritis later in life.

PI_NAMEs: ANDERSON, ANDREW EDWARD (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: 3-Dimensional;Accounting;Address;Adopted;Anatomy;Ankle;Arthritis;Arthrodesis;base;Biomechanics;calcaneum;Cartilage;Clinical;clinical effect;Compensation;Complex;Data;Deformity;Degenerative polyarthritis;Development;disability;Enrollment;Exhibits;experience;experimental study;Film;Fluoroscopy;foot;Future;Goals;improved;in vivo;Inferior;insight;Intervention Studies;Ipsilateral;Joints;kinematics;Leg;Life;Limb structure;Measures;Mechanics;Medial;Mediating;Modeling;Morphology;Motion;Operative Surgical Procedures;Outcome;Pain;pain relief;Patient Outcomes Assessments;Patient Recruitments;Patient-Focused Outcomes;Patients;Physical Function;Postoperative Period;Quality of life;Recommendation;Research;Risk;Role;Scanning;Schedule;Shapes;structural determinants;subchondral bone;Subtalar joint structure;Surgeon;Testing;tibia;Time;Walking;Weight-Bearing state;X-Ray Computed Tomography

PROJECT_TITLE: Morphologic and Kinematic Adaptations of the Subtalar Joint after Ankle Fusion Surgery in Patients with Varus-type Ankle Osteoarthritis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Chronic Pain;Clinical Research;Comparative Effectiveness Research;Digestive Diseases;Health Services;Liver Disease;Pain Research;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Pain is a highly prevalent and undertreated symptom in patients with cirrhosis, a population which may also be particularly vulnerable to adverse outcomes related to pain medications. Currently, there is limited understanding of how pain is managed or the actual, real-world harms associated with use of pain medications in this population. This proposal aims to quantify the harms of specific types of pain medications in cirrhosis patients, using these data to develop evidence-based guidance to help clinicians feel more comfortable managing pain, improving quality of life and outcomes for patients with cirrhosis.

PI_NAMEs: RUBIN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: Acetaminophen;active comparator;Address;Adverse effects;Adverse event;adverse outcome;Affect;American;Analgesics;Biometry;Biostatistical Methods;California;career development;Caring;Characteristics;chronic pain;Cirrhosis;Clinical;clinical care;Clinical Data;clinical phenotype;clinical practice;cohort;Collection;comorbidity;Confusion;Consensus;cost;Data;data dissemination;data management;data resource;Data Set;data warehouse;Development;Diagnosis;Drug Kinetics;Electronic Health Record;Epidemiology;epidemiology study;Etiology;evidence base;experience;Fostering;Foundations;Future;General Population;Goals;health service use;Health Services;Health Services Research;Healthcare Systems;Hemorrhage;Hepatology;Impairment;improved;Individual;large datasets;Literature;Longitudinal cohort;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolism;Methodology;Methods;Modeling;multidisciplinary;Non-Steroidal Anti-Inflammatory Agents;Nonpharmacologic Therapy;Opioid;Opioid Analgesics;Outcome;Outcomes Research;Output;Overdose;Pain;Pain management;Patient-Focused Outcomes;Patients;Pattern;Pharmacoepidemiology;pharmacologic;Physicians;Policies;Population;Population Heterogeneity;Positioning Attribute;Practice Management;pragmatic trial;Predisposition;Primary Care;Process;Provider;Publishing;Quality of life;Recommendation;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Support;Risk;Risk Factors;Safety;San Francisco;seal;Severities;skills;Symptoms;Techniques;Testing;Time;tool;Training;Translating;Translations;Universities;Veterans;Veterans Health Administration;Work;Writing

PROJECT_TITLE: Using real-world evidence to define safe pain management strategies in cirrhosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The inheritance of a particular gene expression profile is key to conveying proper cellular identity to progeny cells upon cell division. The proposed studies will directly expose key mechanistic aspects and biologically relevant factors inherent to this epigenetic regulation, as well as the sequence of events that accompany leukemogenesis as a consequence of naturally occurring mutations that target this inheritance.

PI_NAMEs: REINBERG, DANNY  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult Acute Myeloblastic Leukemia;Affect;Auxins;Base Pairing;Binding;Biological;Biological Assay;Cell Cycle;Cell Cycle Stage;Cell division;Cells;Chromatin;Chromatin Structure;Compensation;Complex;Cytoplasm;daughter strand;Deposition;derepression;Disease;DNA;DNA biosynthesis;DNA Methylation;DNA replication fork;DNMT3a;DNMT3a mutation;Epigenetic Process;epigenetic regulation;epigenome;Essential Genes;Event;Exhibits;Exons;Family;Foundations;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Gene Targeting;Genes;grasp;Heterochromatin;Histones;Homeobox Genes;Human;In Vitro;in vivo;Individual;Inherited;Investigation;Karyotype;knock-down;Label;leukemia;leukemogenesis;Lysine;Maintenance;Mammalian Cell;Mediating;metaplastic cell transformation;Methods;Methylation;microscopic imaging;Microscopy;Modification;Molecular;Molecular Chaperones;Monitor;Mouse Embryonic Stem Cells;mouse model;Mus;mutant;Mutate;Mutation;Myeloproliferative disease;NPM1 gene;nucleophosmin;nucleoplasmin;Nucleosomes;Oncogenes;Optics;Polycomb;Post-Translational Protein Processing;preservation;protein complex;Protein Isoforms;Proteins;Proteomics;reconstruction;Reporting;Repression;Role;S phase;segregation;Series;single molecule;synergism;tissue culture;Transcript;tumorigenic;Visualization;Writing

PROJECT_TITLE: Repression via Facultative Heterochromatin

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative Based on the hypothesis that the peripheral inflammation to neuroinflammation pathway largely drives the relationship between periodontal disease and Alzheimer’s disease, our long-term goal is to investigate the full spectrum of oral organisms that drive this association, and with an understanding of related social determinants that affect oral health, evaluate their potential as a target in the development of oral health interventions for the mitigation of Alzheimer’s disease onset and progression. The main objective of this study is to characterize the taxonomy and function of oral bacteria, viruses and fungi among cognitively normal individuals at risk for Alzheimer’s disease, and over a two-year period, investigate relationships among periodontal disease associated microbiome features, inflammation, social determinants of oral health, and Alzheimer’s disease central cerebrospinal fluid biomarkers.

PI_NAMEs: YANG, IRENE  (contact)

PROGRAM_OFFICER_NAME: DHRUV, NEEL TUSHAR

PROJECT_TERMS: Address;Adult;Affect;Age;aging population;Alleles;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;apolipoprotein E-4;Bacteria;Behavior;Biological Markers;Biometry;Blood;Candida albicans;Cerebrospinal Fluid;Chronic;Clinical;clinical examination;clinically relevant;Cognitive;cohort;Culture-independent methods;Data;Dentistry;Development;Diagnosis;diagnostic development;Disease;Disease Marker;Disease Progression;Education;Enrollment;Epidemiology;Ethnic Population;Etiology;Exposure to;Family;Family history of;Feasibility Studies;Forsythia;Funding;fungus;Fusobacterium nucleatum;Future;Genetic;Gingiva;Goals;Health;health care availability;high risk;Human;Hygiene;Individual;Inequity;Infection;Inflammation;Inflammatory;inflammatory marker;interest;Intervention;Interview;Investigation;Knowledge;Life Style;Link;Longitudinal cohort study;Medical;Microbial Biofilms;microbiome;microbiota;middle age;modifiable risk;multidisciplinary;neuroinflammation;Neuropsychological Tests;novel;older adult;Onset of illness;Oral;oral bacteria;Oral cavity;Oral Characters;oral condition;Oral Examination;Oral health;Oral Microbiology;oral microbiome;oral spirochetes;Organism;Participant;Pathogenesis;Pathway interactions;Periodontal Diseases;Periodontium;periodontopathogen;Peripheral;Pharmaceutical Preparations;Porphyromonas gingivalis;prevent;Quality of life;racial diversity;racial population;Recording of previous events;Research;Risk;Risk Factors;Role;Saliva;Salivary;sample collection;Sampling;social;social determinants;social health determinants;Societies;Structure;Surveys;Symptoms;systemic inflammatory response;tau Proteins;tau-1;Taxonomy;Time;Tissues;Tooth structure;Treponema denticola;United States National Institutes of Health;Viral;Virus;Visit

PROJECT_TITLE: The Contribution of the Oral Microbiome to Alzheimer’s Disease Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Z(55)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric;Tourette Syndrome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The majority of patients with Tourette Syndrome and other chronic tic disorders do not experience adequate benefit from the first-line tic treatment, Comprehensive Behavioral Intervention for Tics (CBIT). This study will measure brain, behavioral, and psychosocial functioning in patients receiving CBIT to identify predictors of response (for whom does CBIT work?), the therapeutic processes that activate change (what are the potent aspects of CBIT delivery?), and correlates of response (what changes occur in patients whose tics improve?). Results will help guide treatment decision-making for patients and providers and reveal novel targets for treatment development research in the future.

PI_NAMEs: CONELEA, CHRISTINE A;WANG, SONYA GRACE (contact)

PROGRAM_OFFICER_NAME: GARVEY, MARJORIE ANN

PROJECT_TERMS: Affect;Age;associated symptom;Behavior;behavior measurement;behavior observation;Behavior Therapy;Behavioral;bench-to-bedside translation;biobehavior;Brain;Child;Childhood;Chronic;Clinical;Clinical assessments;clinical practice;Clinical Trials;Code;Data;Decision Making;design;Disabling;efficacy trial;Electroencephalography;Elements;experience;follow up assessment;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Gilles de la Tourette syndrome;Goals;Impairment;Improve Access;improved;Impulsivity;indexing;individualized medicine;Intervention;Knowledge;Link;Literature;Logistic Regressions;magnetic resonance imaging/electroencephalography;Measurement;Measures;member;Mental disorders;Methods;Modeling;Motor;motor control;Movement;Multi-Institutional Clinical Trial;multidisciplinary;multimodality;neural;neuropsychiatric disorder;neuropsychiatric symptom;neuroregulation;novel;Obsessive-Compulsive Disorder;Outcome;Outcome Measure;Outpatients;patient engagement;Patient-Focused Outcomes;Patients;predicting response;predictive marker;predictive modeling;primary care setting;Procedures;Process;profiles in patients;prognostic indicator;Provider;psychosocial;repetitive behavior;Research;research and development;response;Rest;Sampling;Seminal;Severities;Signal Transduction;skills;standard care;support network;Symptoms;Therapeutic;therapeutic target;therapy development;Tic disorder;tic suppression;treatment adherence;treatment planning;vocalization;Work;Youth

PROJECT_TITLE: Multimodal Profiling of Response to Pediatric Comprehensive Behavioral Intervention for Tics

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: LOS ANGELES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative This project seeks to develop synthetic nanomaterials inspired by bacteriophages and study their fundamental properties as well as antibacterial potential. This knowledge could lead to new antibacterial therapies and biotechnologies.

PI_NAMEs: CHEN, IRENE ANN (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TITLE: Phage-inspired engineering and evolution


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Mental Health;Mental Illness;Prevention;Rural Health;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_DEPT: OTHER CLINICAL SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE  While permanent supportive housing is typically situated in high-risk environments, it is also surrounded by public spaces that can be resourceful and supportive for formerly incarcerated people with serious mental illnesses. The risk environment framework provides a structure for understanding the geography of permanent supportive housing during reentry, including the individual, interpersonal, and environmental factors interacting with these spaces to reduce risk and promote reentry wellbeing. This project involves career development and training activities that will enhance the applicant’s expertise in spatial methods supportive housing and the risk environment framework, community-based intervention development, and community-based participatory research methods to help support the use and interaction of public and private spaces in supporting reentry from prison for people with serious mental illnesses.

PI_NAMEs: KRIEGEL, LIAT S. (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Address;Area;career;career development;Case Management;Client;Clinical;Cluster Analysis;Communities;community advisory board;community based participatory research;Community Integration;community intervention;Community Participation;Data;design;Development;Development Plans;Distress;Economics;Employment;Environment;Environmental Risk Factor;experience;Geography;Goals;health disparity;high risk;Home;Homelessness;Housing;Imprisonment;improved;indexing;Individual;innovation;Intervention;Interview;Jail;Legal;Legal system;Life;Maps;Medical;Mental Health;Mentored Research Scientist Development Award;Mentorship;Methods;Modeling;National Institute of Mental Health;Overdose;Participant;participatory mapping;peer;Personal Satisfaction;Persons;Pharmaceutical Preparations;Policies;Poverty;Prisons;Privatization;Provider;recidivism;Recovery;Research;Research Methodology;Research Personnel;resilience;Resources;Risk;Risk Reduction;Role;Rural;Sampling;satisfaction;self esteem;Service delivery model;severe mental illness;Site;social;social capital;Social Interaction;Social isolation;Social support;Structure;substance use;Substance Use Disorder;supported housing;therapy development;Training;Training Activity;Work

PROJECT_TITLE: Risk Environments of Permanent Supportive Housing for Formerly Incarcerated People with Serious Mental Illnesses

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: American Indian or Alaska Native;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Racial minorities in the United States have a disproportionately higher burden of heart failure and often receive worse quality of care, however, studies of American Indian/Alaska Native patients are limited. This study aims to characterize the disease burden, quality of care, and outcomes of American Indians/Alaska Natives with heart failure receiving care through the Indian Health Service, as well as develop strategies to ensure quality heart failure care for this population. The findings of this study will allow better understanding of the current state of cardiovascular health of the American Indian/Alaska Native population and ways in which it can improved, and will also inform a future pragmatic clinical trial seeking to improve cardiovascular outcomes for this vulnerable population.

PI_NAMEs: EBERLY, LAUREN A (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: access disparities;Address;Advisory Committees;Africa South of the Sahara;Alaska Native;Alaska Native population;American Indian Population;American Indians;Award;Behavior;burden of illness;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;care delivery;career;Caring;Characteristics;Chronic Disease;Clinical;clinical database;clinical training;Collaborations;combat;Coronary heart disease;cost;Data;Data Sources;Databases;Death Rate;Devices;Disparity;effectiveness evaluation;Ensure;Equity;evidence base;Face;Familiarity;Funding;Future;General Population;Goals;Guidelines;health care availability;health disparity;Health Personnel;Health Priorities;Health Services;Heart failure;heart failure with reduced ejection fraction;high risk;Hospitalization;implementation science;implementation strategy;improved;Incidence;Inequity;innovation;Institution;Interview;Literature;Maps;marginalization;marginalized population;Medical;Mentors;Mentorship;Methodology;Modeling;Morbidity - disease rate;mortality;Navajo;Outcome;Patient Discharge;patient oriented;Patients;Pharmaceutical Preparations;Pharmaceutical Services;Population;Pragmatic clinical trial;Provider;Public Health;Publishing;Qualitative Research;Quality of Care;Race;racial minority;racial population;Recommendation;Research;Research Methodology;Research Personnel;Research Priority;Research Training;Resources;Rural;Service delivery model;service providers;Site;Specialist;Structure;study population;System;Testing;theories;Therapeutic;Time;Training;trend;Tribes;United States;United States Indian Health Service;United States National Institutes of Health;uptake;Variant;Vulnerable Populations;Work

PROJECT_TITLE: Improving the Quality of Heart Failure Care for American Indian Patients Receiving Care through the Indian Health Service

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal focuses on the design, development, and evaluation of open-source data visualization and analytical tools for computational analysis of high-dimensional, spatially-resolved image and omics data. Such data promise to revolutionize how we study and diagnose cancer and their exploration, quantification, and distribution will be greatly accelerated by the tools we will develop and make available to the community.

PI_NAMEs: PFISTER, HANSPETER  (contact);SANTAGATA, SANDRO

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;analytical method;analytical tool;Architecture;Atlases;Back;Biological;Biological Markers;Biology;cancer diagnosis;Cancer Research Project;Cell Communication;Cells;Clinical;cloud based;Collaborations;Communication;Communities;Complex;complex data;Computer Analysis;computer infrastructure;Computer software;cost;Coupled;Cultured Cells;Data;Data Analyses;Data Collection;data communication;data dissemination;data exploration;data integration;data repository;Data Set;data sharing;data visualization;Databases;design;Development;digital;digital pathology;Disease Progression;diverse data;Education;Educational process of instructing;Elements;Evaluation;experimental study;FAIR principles;Generations;Genes;Hematoxylin and Eosin Staining Method;high dimensionality;Human;Human BioMolecular Atlas Program;human-in-the-loop;Image;Image Analysis;Immunologic Surveillance;improved;Individual;Informatics;innovation;interest;International;interoperability;Intuition;Invaded;Knowledge;Label;Laboratories;Length;light weight;Machine Learning;Malignant Neoplasms;Manuscripts;mass spectrometric imaging;Measurement;Messenger RNA;Metadata;Methods;Microscope;microscopic imaging;Modeling;Morphology;multimodal data;Multimodal Imaging;multimodal learning;Mutation;Neighborhoods;next generation;Normal tissue morphology;Oncologist;Online Systems;open data;open source;open source tool;Paper;Participant;Pathologist;Pattern;Phase;Process;professional atmosphere;programs;protein biomarkers;Publications;Publishing;Research;Resolution;single-cell RNA sequencing;skills;Slide;small molecule;Software Tools;Solid;Source;Specimen;Structure;Techniques;Technology;Testing;The Cancer Genome Atlas;Three-Dimensional Image;Tissue atlas;Tissue imaging;Tissues;tool;Training;Transcript;transcriptomics;tumor;tumor initiation;tumor microenvironment;United States National Institutes of Health;usability;User-Computer Interface;Visual;Visualization;Visualization software;web-based tool;Weight;whole slide imaging;Work

PROJECT_TITLE: Visual Analytics for Exploration and Hypothesis Generation Using Highly MultiplexedSpatial Data of Tissues and Tumors


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: NEW YORK

ORG_NAME: STATE COLLEGE OF OPTOMETRY

PHR: PROJECT NARRATIVE Current rehabilitation programs for people with ultra-low vision (ULV) (VA<20/1600) mainly involve sensory substitution training with audio and haptic devices with no recommendations for maximizing the use of their residual vision. It is not known whether and how residual vision plays a role in functional vision performance when integrated with other senses in people with ULV. The proposed research will address this critical gap in knowledge and develop a multisensory rehabilitation program using, among others, assessment and training in virtual reality to improve functional vision and independence in people with ULV, in keeping with NIH’s mission to improve quality of life through innovative use of technology and devices in rehabilitation research.

PI_NAMEs: KARTHA, ARATHY GANGA (contact);WITTICH, WALTER

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: age related;aging population;American;Area;Auditory;auditory feedback;blind;Blindness;Canada;career;Cream;Cues;Darkness;Data;Dedications;design;Development;Devices;Educational process of instructing;effectiveness evaluation;effectiveness study;evidence base;Evidence based program;Exclusion;experimental study;Eye;eye hand coordination;feasibility testing;Frustration;gene therapy;Goals;grasp;Hand;haptic feedback;haptics;improved;Individual;information gathering;innovation;Knowledge;Letters;Life;Light;Location;Measures;member;Mentors;Methods;Mission;Modeling;multimodality;multisensory;Outcome;Outcome Measure;Outcomes Research;Participant;Patients;Pattern;Performance;performance tests;Persons;Phase;Population;programs;Prosthesis;Protocols documentation;Psychophysics;Quality of life;Questionnaires;Recommendation;Recovery;Rehabilitation Outcome;rehabilitation research;rehabilitation strategy;Rehabilitation therapy;Research;Residual state;Retina;Sensory;Sensory impairment;sensory integration;sensory substitution;Shapes;sight restoration;skills;Source;Space Perception;stem cell therapy;Tactile;Techniques;Technology;Testing;tool;Touch sensation;Training;Training Programs;Tube;United States National Institutes of Health;Universities;vestibular system;virtual environment;virtual reality;virtual reality environment;Vision;vision rehabilitation;Visual;visual feedback;Visual impairment;visual information;visual performance;Washington;way finding;Weight;Work

PROJECT_TITLE: Development of a Multi-sensory Rehabilitation Program for People with Ultra Low Vision


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Opioid Misuse and Addiction;Opioids;Primary Health Care;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: CAMBRIDGE

ORG_NAME: DIMAGI, INC.

PHR: PROJECT NARRATIVE Substance use disorder (SUD) is a major public health challenge in the United States that has been further exacerbated in recent years by the Covid-19 pandemic and social isolation, leading to a higher demand for treatment with limited provider capacity to meet the need. In this Phase II SBIR project, we will evaluate the effectiveness and implementation of Suzy, an innovative mobile- and web-based chatbot designed to provide engaging, scalable, on-demand follow-up support for primary care patients on the path to SUD recovery. Suzy will be developed with features that are evidence-based and will follow a community-based continuing care model with an interface designed with and for individuals who struggle with SUDs.

PI_NAMEs: HO, Y. XIAN  (contact);JACKSON, JONATHAN LEE

PROGRAM_OFFICER_NAME: FLOOD, MORRIS

PROJECT_TERMS: Acute;addiction;Address;Adherence;Adoption;Age;Appointment;behavioral health;Caring;Characteristics;chatbot;Client;Clinic;Clinic Visits;Clinical;clinical care;commercialization;Communication;Communities;cost;Cost Analysis;cost effective;cost effectiveness;cost estimate;cost outcomes;Costs and Benefits;COVID-19 pandemic;craving;Criminal Justice;Data;design;Development;digital;Drug usage;Economics;Effectiveness;effectiveness evaluation;Emergency department visit;Enrollment;Ensure;Ethnic Origin;Event;evidence base;experience;follow-up;Funding;Future;Gender;Goals;Health;health data;Health Insurance Portability and Accountability Act;Health Personnel;Health Services Accessibility;Health Status;Healthcare;Hospitalization;human centered design;implementation cost;implementation evaluation;improved;indexing;indigenous community;Individual;innovation;Intervention;intervention cost;Intervention Studies;Interview;Investments;Link;marginalized population;Measures;Medicare/Medicaid;member;Mental Health;Methods;Modeling;novel;Online Systems;opioid use disorder;Outcome;Outcome Study;overdose death;Participant;Patient Care;patient engagement;Patients;peer recovery;Personal Satisfaction;Persons;Pharmaceutical Preparations;Phase;Play;post intervention;pragmatic trial;primary care patient;primary care provider;Prisons;Productivity;prototype;Provider;Public Health;Quality of life;Race;Recommendation;Recovery;Recurrence;reduced substance use;remote health care;Resources;Risk;Role;Running;rural area;Sampling;secondary analysis;secondary outcome;Severities;sex;Small Business Innovation Research Grant;Social isolation;Specialist;Speed;Structure;substance use;Substance Use Disorder;substance use treatment;Surveys;System;Systems Analysis;Techniques;Technology;Testing;Time;Training;United States;uptake;usability;Visit;waiver;Work

PROJECT_TITLE: A conversational agent to support remote care for individuals with substance use disorder


NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Regenerative Medicine;Rehabilitation

ORG_CITY: Columbus

ORG_DEPT: NEUROSURGERY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Spinal cord stimulation (SCS) is a validated treatment for pain, including with painful diabetic peripheral neuropathy (PDPN), the most common form of small fiber neuropathy that impacts more than half of patients with diabetes. The mechanisms by which SCS improves pain are not known, but may include the promotion of small fiber nerve plasticity and regeneration, which we will test in this study in PDPN patients across 3 groups: conventional medical management, SCS, and SCS with a delayed start of stimulation. We will compare traditional measures of neuropathy (small and large fiber), including a new measurement of small fiber nerve electrical activity with the Detecting Early Neuropathy (DEN) device, with improvements in pain scores across an 18mo longitudinal study with the hypothesis that pain improvement correlates with better tissue innervation.

PI_NAMEs: DALM, BRIAN ;TOWNSEND, KRISTY L (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Accounting;Age;American;Ankle;Biometry;Biopsy;Blood;Blood Pressure;Body fat;Body mass index;Clinic;Clinic Visits;Clinical;Clinical Management;cohort;Data;Data Set;Dependence;design;Detection;Development;Devices;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Neuralgia;Diabetic Neuropathies;Diagnosis;Diagnostic Equipment;diagnostic signature;Diagnostic tests;Distal;Early Diagnosis;effective therapy;Electric Stimulation;Electromyography;fasting glucose;FDA approved;Fiber;follow-up;foot;Glycosylated hemoglobin A;Goals;Growth;Heart Rate;Histologic;Human;Implant;implantable device;implantation;improved;innovation;instrument;Length;Link;Lipids;Location;longitudinal dataset;Longitudinal Studies;machine learning algorithm;Manufacturer;Measurement;Measures;Mechanics;Medical;Metabolic;Methods;Michigan;Natural regeneration;Needles;Nerve;Nerve Fibers;Nerve Regeneration;nerve supply;Nerve Tissue;Neural Conduction;Neurologist;Neuronal Plasticity;Neuropathy;neuroregulation;Neurostimulation procedures of spinal cord tissue;neurotrophic factor;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Operative Surgical Procedures;Opiate Addiction;Opioid Analgesics;Pain;Pain management;Pain Measurement;pain reduction;pain score;painful neuropathy;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System Diseases;Placebo Control Effect;Placebo Effect;Population;Prediabetes syndrome;preimplantation;primary endpoint;Quality of life;Recovery;Research;Research Personnel;Risk;screening;secondary endpoint;sex;SF-36;Skin;Skin Tissue;Spinal;Spinal Cord;Spinal nerve structure;Stimulus;Subcutaneous Tissue;Surface;Surgeon;Testing;Thigh structure;timeline;Tissues;treatment group;Validation;Vertebral column;Visit;Work

PROJECT_TITLE: Functional and histological changes to peripheral innervation following spinal cord stimulation in patients with painful diabetic neuropathy


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Kidney Disease;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Our goal is to establish a diabetes and kidney disease study site (DSS) comprised of 300 racially and ethnically diverse participants, including 200 with diabetes (half with kidney disease) and 100 healthy controls. Our DSS will be part of a collaborative initiative with an overall mission to advance the application of integrative multi-omics technologies to study health and disease in ancestrally diverse populations.

PI_NAMEs: ARGOS, MARIA ;KELLY, TANIKA NICOLE (contact);RICARDO, ANA CATHERINE

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Adult;Affect;analytical method;Biological;Biological Markers;Black Populations;Black race;Blood;blood glucose regulation;blood pressure control;Blood specimen;Chicago;Chronic Kidney Failure;Clinical Research;cloud based;cohort;Collaborations;Collection;Data;data analysis pipeline;Data Collection;Data Linkages;Development;Diabetes Mellitus;Diabetic Nephropathy;Disease;Disease Progression;disorder prevention;Disparity;Ecosystem;effective intervention;Electronic Health Record;eligible participant;end stage disease;End stage renal failure;Environment;Environmental Exposure;epigenomics;ethnic diversity;experience;Exposure to;Face;Generations;Genomics;Goals;Health;Health Sciences;Health system;Hispanic;hispanic community;Hispanic Populations;Histopathology;Hospitals;Illinois;Informatics;Infrastructure;innovation;Intervention;Kidney;Kidney Diseases;kidney preservation;Link;Measures;metabolomics;Metals;Methods;Mission;Molecular;Molecular Profiling;mortality;multidisciplinary;Multiomic Data;multiple omics;National Human Genome Research Institute;Natural History;Not Hispanic or Latino;novel;novel strategies;Outcome;Participant;patient population;Patient Recruitments;Patients;peripheral blood;Pharmaceutical Preparations;Phenotype;Population;Population Heterogeneity;Precision Health;precision medicine;Process;Proteomics;protocol development;Protocols documentation;Public Health;racial diversity;recruit;Renal function;Renin-Angiotensin-Aldosterone System;Research;Research Methodology;Residual state;Risk;Role;Sampling;Site;social health determinants;System;Systems Biology;Technology;Testing;Time;Tissues;transcriptomics;Universities;Variant;Visualization;Work

PROJECT_TITLE: Multi-Omics at the Intersections of Environment, Diabetes, and Kidney Disease: A Multi-Omics for Health and Disease Study Site


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The Washington University Postbaccalaureate Program (WUP) is a one-year, multi-pronged program designed to increase the number of underrepresented individuals matriculating and graduating from research-intensive biomedical doctoral programs. The WUP will achieve this through a rigorous mentored research experience and career and educational programs designed to enhance scientific self-efficacy, sense of belonging, identity, and communication skills of participating scholars.

PI_NAMEs: GRANT, GREGORY A;KAST, DAVID J;TRUE-KROB, HEATHER L (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Anxiety;Area;Biochemistry;Biology;Biomedical Research;biomedical scientist;career;Career Choice;career development;Career Mobility;Cellular biology;cohort;college;commune;Communication;Communities;Critical Thinking;Decision Making;Dedications;Degree program;design;Development;Development Plans;disabled;Disabled Persons;disabled students;Disadvantaged;disadvantaged student;Disparity population;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;Education;education research;Educational workshop;effectiveness evaluation;Eligibility Determination;Enrollment;Ensure;Environment;Equity;equity, diversity, and inclusion;Ethics;Evaluation;experience;Faculty;Funding;Goals;graduate school;graduate school preparation;graduate student;Grant;improved;Individual;Infrastructure;innovation;Institution;Instruction;interest;intervention program;Interview;Journals;Laboratories;Leadership;matriculation;Measures;medical schools;Mentors;Oral;Participant;Periodicals;Population;Postbaccalaureate;Preparation;Process;Productivity;programs;psychologic;Public Speaking;Records;Regenerative Medicine;Reproducibility;Research;Research Personnel;Research Training;Running;Scholars Program;Science;Self Assessment;Self Efficacy;Series;skills;socioeconomics;Structure;Students;success;Talents;Training;Training Programs;trait;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Washington;Writing

PROJECT_TITLE: Washington University Postbaccalaureate Research Education Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: Project Narrative Abnormal activation of the complement pathway, which regulates innate immunity and inflammation, is associated with blinding diseases such as inherited and age-related macular degenerations. This research will investigate how a novel pathway of intracellular complement activation endangers the health of the retinal pigment epithelium, a key site of insult in macular degenerations. We will study the impact of intracellular complement on the function and integrity of the retinal pigment epithelium, and identify potential points of therapeutic intervention that can be targeted to preserve vision.

PI_NAMEs: LAKKARAJU, APARNA  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Age related macular degeneration;ATP binding cassette transporter 1;Atrophic;Autophagocytosis;Biogenesis;Blindness;Cell Physiology;Cells;Ceramides;Cholesterol;cholesterol transporters;Chronic;Complement;Complement Activation;complement pathway;complement system;Data;Defect;design;Development;Disease;disease model;Drusen;Early Endosome;Endosomes;Equilibrium;extracellular;Extracellular Space;FRAP1 gene;Functional disorder;Generations;Genes;Genetic Polymorphism;Health;Homeostasis;Human;Image;Inflammation;Inflammatory;Inherited;Injury;innovation;insight;Link;Lipofuscin;live cell imaging;Location;Macular degeneration;Mediating;Metabolic;Metabolism;Mitochondria;Modeling;Molecular;mouse model;Mus;Natural Immunity;novel;Pathogenicity;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;photoreceptor degeneration;Play;Precision therapeutics;preservation;prevent;Process;programs;Proteolysis;receptor;Receptor Activation;Receptor Inhibition;Receptor Signaling;Recycling;Research;Retina;Retinal Degeneration;Retinal Diseases;Role;Secondary to;segregation;Signal Transduction;Site;Speed;Stress;Structure of retinal pigment epithelium;Swelling;Therapeutic;Therapeutic Intervention;therapeutic target;trafficking;ultra high resolution;uptake;Vision

PROJECT_TITLE: Diversity Supplement Nguyen 2023-2025


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Kidney Disease;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE This proposal is relevant to public health since it would: 1. Add scale to the study of genetic variants related to CKD, more particularly by having power to identify  rare variants associated with this condition which has not been addressed by prior studies. By conducting  gene-burden analysis in a diverse sample comprising 850,000 participants with whole-genome or whole-  exome sequencing information, we will improve our ability to identify people carrying increased genetic  risk related to CKD, opening opportunities for primary and secondary prevention. 2. This will be the largest study addressing the penetrance of CKD-related variants in an unbiased way.  Absolute and unbiased association estimates between CKD-related variants and CKD and other renal  phenotypes will be computed and stratified by age, sex, and comorbidities. These findings will be useful  the interpretation of genetic variants in scenarios where the clinical trait is absent or just partially present.  In conjunction with the finding of rare variants, the results of this proposal are expected to support  investigations in translational research, more specifically in terms of mechanisms of disease,  development of biomarkers, and identification of possible targets for intervention and new therapies. 3. By fostering the career development of a researcher representative of a minority group, the diversity  supplement would empower the candidate to become a strong representative of her minority group within  her Institution and the nephrology community, fostering new similar initiatives, inspiring students and  colleagues from similar backgrounds, and creating opportunities for mentoring within the diversity scope.

PI_NAMEs: GAROVIC, VESNA D (contact)

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Acceleration;Address;age stratification;Albuminuria;Award;biobank;biomarker development;career development;Caring;Chronic Kidney Failure;Clinic;Clinical;clinical center;Clinical Sciences;Clinical Trials;Communities;comorbidity;Competence;Computational algorithm;Cystic kidney;Data;Data Sources;digital;digital health;Disease;disease phenotype;Diverse Workforce;drug development;drug repurposing;Education;empowerment;End stage renal failure;Environment;equity, diversity, and inclusion;exome sequencing;Fostering;Genes;Genetic;Genetic Risk;Genetic study;genetic variant;genomic data;Genomics;Glomerular Filtration Rate;Grant;Health;health equity promotion;Health system;Healthcare;improved;individualized medicine;Informatics;innovation;Institution;Interdisciplinary Study;interest;Investigation;Kidney;Kidney Diseases;Knowledge;Link;Maps;member;Mentors;Meta-Analysis;Methods;Minority Groups;multidisciplinary;Nephrology;novel;novel therapeutics;parent project;Parents;Participant;Pathogenicity;Patient Care;Patients;Penetrance;Persons;Phenotype;Populations at Risk;Preparation;Prevention;Primary Prevention;Process;programs;Public Health;rare variant;repository;Research;Research Personnel;Resources;Sample Size;Sampling;Secondary Prevention;sex;Students;Systems Integration;Testing;Therapeutic Intervention;therapeutic target;Training;trait;Translational Research;Translations;underserved community;Variant;whole genome;Work

PROJECT_TITLE: Mayo Clinic Center for Clinical and Translational Science (CCaTS)


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Clinical translational science could better address health equity if researchers and communities had access to community level data to identify inequities, recognize the people and communities impacted, detect potential underlying causes of and solutions to address disparities, and longitudinally track changes over time. Building on its expertise calculating census tract level community measures, engaging communities to understand needs and priorities, and unique bright spot and community asset mapping approach, the Wright Regional CCTS will develop the Virginia Accountable Health Equity and Action Dashboard (Va-AHEAD) to identify bright and cold spot communities that do better or worse than predicted for 15 equity topics and the modifiable socioecological factors that contribute to outcomes. Once created, we will engage local translational science researchers, learners, care team members, and policymakers to use Va-AHEAD and its community designed products to inform their work, and we will track the use and impact of content on health equity, including the dissemination of the approaches and assets used by bright spot communities for success.

PI_NAMEs: KRIST, ALEXANDER H (contact)

PROJECT_TERMS: Accountability;Address;advanced analytics;Affect;American;burden of illness;care delivery;Caring;Censuses;Characteristics;Cities;clinical care;Clinical Sciences;clinical translation;Collaborations;Communities;community advisory board;community based participatory research;community collaboration;community engagement;community partners;dashboard;Data;data dashboard;Data Sources;data warehouse;Databases;design;Development;Disparity;E-learning;Economic Factors;Educational process of instructing;Effectiveness;Equity;experience;Frequencies;Goals;Health;health care delivery;health care service organization;health equity;health equity promotion;Health equity research;health inequalities;Health system;Healthcare Systems;human centered design;improved;indexing;Inequity;Informatics;Information Systems;Infrastructure;innovation;Intervention;learning community;Life Expectancy;Maps;marginalized community;Measures;Medical Assistance;medical schools;member;Modeling;mortality;North Carolina;novel;opioid mortality;Outcome;Patients;Persons;Phase;Policies;Policy Maker;Population;premature;Premature Mortality;Process;programs;Records;Reporting;Research;Research Methodology;Research Personnel;Resources;Services;social factors;Spottings;success;Surveys;Tennessee;Time;Training;Translational Research;Translations;trend;underserved community;Underserved Population;Universities;usability;Virginia;Vital Statistics;Work

PROJECT_TITLE: Virginia Accountable Health Equity and Action Dashboard (VA-AHEAD):  Community Framing of Equity Data to Support Clinical and Translational Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 CI-3 (01)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biomedical Imaging;Eye Disease and Disorders of Vision;Neurosciences

PHR: PROJECT NARRATIVE Neurological injuries and diseases negatively affect quality of life for millions of people in the US, such as the various visual and oculomotor pathologies (e.g. optic ataxia and oculomotor apraxia) caused by damage to the posterior parietal cortex (PPC). Despite extensive research, much remains unknown about how PPC encodes motor decisions, in part due to technical limitations of existing neural recording technologies. This project aims to increases our understanding of the neuronal circuits involved in these visual-motor pathologies by using a novel neuroimaging technique (functional ultrasound neuroimaging) and conventional electrophysiology to investigate how and where motor and decision variables are represented from the single neuron level to detailed maps of neural populations across the entire PPC.

PI_NAMEs: GRIGGS, WHITNEY SCOTT (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Affect;Anatomy;Animals;Anterior;Apraxia;Area;Ataxia;Bilateral;Brain region;cerebral hemodynamics;clinical application;Complex;cortex mapping;Cues;Data;Doctor of Philosophy;Electrophysiology (science);environmental change;Exhibits;Eye;Fingers;Functional disorder;Functional Magnetic Resonance Imaging;Future;Hand;hemodynamics;Human;Image;in vivo;innovation;Knowledge;lateral intraparietal area;Lesion;Link;Liquid substance;Location;Macaca mulatta;Maps;Measures;Mentorship;meter;Methods;Motor;motor disorder;Movement;multisensory;Music;Nervous System Disorder;Nervous System Trauma;neural;neuroimaging;neuronal circuitry;Neurons;neurovascular coupling;nonhuman primate;novel;oculomotor;Optics;Parietal;Parietal Lobe;Pathology;Patients;Pattern;Persons;Physicians;Play;Population;Probability;Quality of life;Reporting;Research;Resolution;response;Rewards;Role;Saccades;Scientist;Signal Transduction;skills;spatiotemporal;Specific qualifier value;Techniques;Technology;temporal measurement;Testing;ultrasound;Validation;ventral intraparietal area;Visual;visual motor;Visual Motor Coordinations

PROJECT_TITLE: Uncovering the Internal Representation of Actions in Posterior Parietal Cortex


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MOUNTAIN HOME

ORG_NAME: JAMES H QUILLEN VA MEDICAL CENTER

ORG_STATE: TN

PHR: People with tinnitus, or ringing in the ears, frequently report that it impacts their ability to concentrate and can make them feel depressed or anxious. Recently, about 1.5 million adults in the US said that their tinnitus was a “big or very big problem.” Veterans report higher rates of tinnitus than the public, so we expect there to be proportionately more Veterans bothered by their tinnitus. There are no practical ways to measure tinnitus because we cannot pinpoint its location, making it hard to treat. We think that when tinnitus becomes difficult to ignore, people must work harder to listen. We also think that when tinnitus makes people feel depressed or anxious, their bodies respond negatively to certain sounds and pictures. If we are correct, we plan to use these tools to improve how we identify and treat Veterans with bothersome tinnitus.

PI_NAMEs: GIULIANI, NICHOLAS  (contact)

PROJECT_TERMS: Address;Adult;Affect;Affective;Anxiety;anxious;Area;Arousal;associated symptom;Attention;Audiology;auditory stimulus;Behavioral Model;blast exposure;Categories;Clinic;Cognitive;comorbidity;Data;Depressed mood;design;Development;disability;Distress;Ear;Exhibits;experience;Fatigue;Feasibility Studies;Galvanic Skin Response;Goals;Health;hearing impairment;Heart Diseases;Image;improved;Kidney Diseases;Link;Location;Measurement;Measures;medical specialties;Mental Depression;Methods;military veteran;Modeling;Monitor;multitask;Mydriasis;normal hearing;Participant;Patients;Pattern;Personal Satisfaction;Persons;Physiological;Post-Traumatic Stress Disorders;Pupil;recruit;Reporting;Research;Resources;response;selective attention;Services;Sleeplessness;sound;Stimulus;Sympathetic Nervous System;Symptoms;Testing;Therapeutic;therapy design;Thinking;Tinnitus;tool;Traumatic Brain Injury;United States;Veterans;visual stimulus;Work

PROJECT_TITLE: Using sympathetic nervous system responses to evaluate distressing tinnitus: a pupillometry and skin conductance feasibility study.

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Racial discrimination is one of the most common stressors reported by Black individuals and is related to a host of negative outcomes including increased substance use among Black youth. The current project will use a mixed method longitudinal design to examine individual, interpersonal, and contextual factors influencing emotional health and substance use outcomes over time among Black youth who experienced racial discrimination. Findings will help identify novel leverage points for strengths-based interventions that jointly address experiences of discrimination and substance use to improve emotional health among Black youth.

PI_NAMEs: REIS, STEVEN E (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Address;Adolescence;Adolescent and Young Adult;Adolescent Development;adolescent substance use;Affect;Age;Alcohol consumption;Behavior;binge drinking;Black Populations;Black race;career;career development;Clinical Sciences;Cluster randomized trial;Communities;Complex;contextual factors;coping;Coping Skills;Data;data infrastructure;Development;didactic education;Dimensions;Discrimination;District of Columbia;Ecology;Economics;Ecosystem;Emotional;experience;Exposure to;follow-up;forging;Friends;Future;Gender;Goals;Health;improved;Individual;innovation;insight;Institution;Intervention;Interview;Justice;Link;longitudinal design;Longitudinal Surveys;marijuana use;Mental Health;Mentors;Mentorship;Methods;Minority Groups;Modeling;Neighborhoods;novel;Outcome;perceived discrimination;Personal Satisfaction;physical conditioning;pilot test;Prevention Research;protective factors;psychologic;Psychologist;Qualitative Methods;Race;racial discrimination;racial identity;recruit;Reporting;Research;Research Infrastructure;Research Personnel;Risk;Risk Factors;skills;social;Social support;stressor;Structure;substance use;Substance Use Disorder;substance use prevention;Surveys;System;Time;training opportunity;Translational Research;Universities;Youth

PROJECT_TITLE: University of Pittsburgh Clinical and Translational Science Institute


ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: OVERALL PROJECT NARRATIVE The Boston University Core Center for Clinical Research will provide broad clinical research expertise with state- of-the-art methods and resources to a large multidisciplinary research community whose research focuses on rheumatic and musculoskeletal diseases including osteoarthritis, crystal-related arthritis, spondyloarthritis, musculoskeletal pain, among others. Our group, which includes persons with backgrounds in rheumatology, physical therapy, epidemiology, biostatistics, behavioral science, engineering, computer science, and pain meets weekly to critically review research projects and serves a broad research community with which it actively engages. The CCCR has been successful in publishing influential papers on the diseases of focus and in training many of the clinical research faculty in the US and internationally.

PI_NAMEs: NEOGI, TUHINA  (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Address;Allied Health Profession;Area;Arthritis;Behavioral Sciences;Biological;Biometry;Boston;Clinical;clinical center;Clinical Research;clinical translation;Clinical Trials;Cohort Studies;Collaborations;Communities;computer science;Consultations;data resource;Data Sources;Databases;Dedications;deep learning;Degenerative polyarthritis;digital health;Disease;doctoral student;Education;Electronic Health Record;Engineering;Ensure;Environment;Epidemiologic Methods;Epidemiology;epidemiology study;Faculty;Feedback;Fostering;Foundations;Funding;Goals;Grant;health application;health inequalities;Health Technology;implementation science;improved;Industry;Influentials;Infusion procedures;insight;Institution;interdisciplinary collaboration;Interdisciplinary Study;International;Journals;Knowledge;Localized Disease;Machine Learning;machine learning method;Manuscripts;Medical;Medical center;medical schools;meetings;Mentors;Methodology;Methods;Musculoskeletal Diseases;Musculoskeletal Pain;novel;Outcome Measure;outreach;Pain;Paper;patient oriented;Peer Review;Persons;Physical therapy;Postdoctoral Fellow;posters;prevent;Privatization;Productivity;Program Evaluation;programs;protocol development;Protocols documentation;Public Health Schools;Publications;Publishing;Research;Research Design;research faculty;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Rheumatism;Rheumatology;Schools;Sensory;Services;Spondylarthritis;success;Talents;Testing;Training;Translational Research;Universities;wearable device

PROJECT_TITLE: Boston University CCCR

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 KM (M1)]


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Chronic Pain;Osteoporosis;Pain Research;Scleroderma

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LAVALLEY, MICHAEL PAUL (contact)

PROJECT_TERMS: Address;Area;Arthritis;Biometry;Boston;Clinical;Clinical Research;clinically relevant;Cohort Studies;Communities;Consultations;Continuing Education;data integrity;Data Sources;Databases;deep learning;Degenerative polyarthritis;digital health;doctoral student;Education;Education and Outreach;education research;Electronic Health Record;Epidemiologic Methods;Epidemiology;epidemiology study;Faculty;Framingham Heart Study;Goals;Grant;health application;Health Benefit;health inequalities;Health Technology;Image;implementation science;improved;Individual;innovation;Interdisciplinary Study;Jackson Heart Study;Journals;Knowledge;Machine Learning;machine learning method;Medicaid;meetings;Mentorship;Methodology;Methods;multidisciplinary;Musculoskeletal Diseases;Musculoskeletal Pain;novel;Outcome Measure;Persons;Postdoctoral Fellow;professor;programs;protocol development;Protocols documentation;Quality of life;Rehabilitation therapy;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Resources;Rheumatism;Rheumatology;Sensory;Series;Services;social media;Spondylarthritis;Testing;Training;Universities;virtual;Visit;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Methodology Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: ONCOSTING LLC

ORG_STATE: MD

PHR: Narrative Aside from COVID-19, TB is the leading cause of death globally from a single infectious disease. At present, the only approved tuberculosis (TB) vaccine—BCG, which was introduced in 1921—has variable efficacy in adolescents and adults. As vaccination remains the most cost-effective method of controlling the disease, an improved vaccine for TB infection and disease prevention would have very large public health impact. This project will support the development of a novel TB vaccine in the form of a novel recombinant BCG strain that compared to traditional BCG has greater protective efficacy that lasts into adulthood, and an improved safety profile.

PI_NAMEs: WALLACH, TODD  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Acceleration;acquired immunity;Address;Adjuvant;Adolescent;Adult;Advanced Development;Aerosols;Agonist;Animal Cancer Model;Animal Model;Antibiotic Resistance;Antitubercular Agents;Attenuated;Attenuated Vaccines;Bacille Calmette-Guerin vaccination;Bacterial Vaccines;BCG Live;BCG Vaccine;Biological Assay;Bone Marrow;Cause of Death;Cavia;Cessation of life;Child;Clinical Trials;co-infection;Communicable Diseases;cost effective;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Cyclic GMP;Data;Databases;Detection;Development;Disease;Disease Progression;disorder control;disorder prevention;DNA cassette;Dose;Drug resistance;efficacy study;Engineering;Evolution;Excipients;Fermentation;Formulation;Freeze Drying;Funding;Goals;Growth;guinea pig model;Hamsters;Health Services Accessibility;HIV/TB;Human;Immune response;Immunity;immunogenicity;improved;In Vitro;in vivo;Infection prevention;Inflammatory Response;interest;Interruption;intravesical;Journals;Kanamycin;Kanamycin Resistance;Kinetics;Life;Liquid substance;Lung;Macrophage;Malignant neoplasm of urinary bladder;manufacture;Medical;Messenger RNA;Methods;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Myeloid Cells;Natural Immunity;Nature;next generation;non-muscle invasive bladder cancer;novel;overexpression;Paper;Pathology;Pathway interactions;Performance;Pharmaceutical Preparations;Phase;phase 3 study;Plasmids;Population;population movement;Positioning Attribute;prevent;Prevention;Production;protective effect;protective efficacy;Protocols documentation;Public Health;Pulmonary Tuberculosis;Recombinants;Recovery;Reporting;Research;Resistance;resistance gene;resistant strain;Role;Running;Safety;Saline;Schedule;side effect;Site;small molecule;Stimulator of Interferon Genes;systemic toxicity;Time;Toxic effect;Toxicology;Training;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;Up-Regulation;Vaccination;vaccine access;vaccine development;Vaccines;Virulent

PROJECT_TITLE: BCG overexpressing a small molecule STING agonist as a vaccine for TB

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative: Modern electron-microscopy imaging and analysis methods permit the comprehensive reconstruction of all neu- rons and synapses in large volumes of brain tissue or the entire brains of individual organisms. This data is now being paired with functional and behavioral measurements, but how to integrate these new data modalities is not clear. Litwin-Kumar’s group is developing analysis methods to translate the rich anatomical information identified in electron microscopy data into insights about how neural circuits give rise to behavior.

PI_NAMEs: LITWIN-KUMAR, ASHOK  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Address;Adult;Anatomy;Behavior;behavior measurement;Behavioral;Benchmarking;Biological Models;Biophysical Process;Brain;BRAIN initiative;Brain region;brain tissue;brain volume;Calibration;Complex;connectome;connectome data;Data;Data Analyses;data modalities;data modeling;Data Set;Data Sources;Decision Making;design;Development;Dimensions;diverse data;Drosophila genus;Effectiveness;effectiveness evaluation;Electron Microscopy;Ensure;Exhibits;Functional Imaging;Future;Generations;Goals;improved;Individual;insight;interest;Knowledge;Link;Mammals;Methodology;Methods;microscopic imaging;model organism;Modeling;Modernization;Motor;Mus;Nervous System;network models;neural;neural circuit;Neurons;Neurosciences;Neurotransmitters;Organism;Pathway interactions;Population;Property;Protocols documentation;reconstruction;Recurrence;Research Personnel;Sensory;statistics;Structure;Synapses;System;technique development;Techniques;Theoretical model;theories;tool;Translating;Uncertainty;Visual

PROJECT_TITLE: Relating structure and function in synapse-level wiring diagrams

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (M1)]