ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: While new medication classes promise to transform diabetes care and reduce diabetes complications, there remains limited evidence of their effects in Veterans with type 2 diabetes. This is largely because Veterans are not well-represented in randomized clinical trials, and Veterans often differ from clinical trial participants across many clinical and demographic characteristics, exacerbating the challenge of generalizing trial results to Veterans. Recent advances in biostatistical methods offer tools for bridging this evidence gap between clinical trials and real-world patient populations. We propose to apply these methods, called transportability methods, to several recent clinical trials in type 2 diabetes to generate valid VA-specific evidence of the efficacy of contemporary diabetes treatments in Veterans. We will then use this real-world evidence in Veterans to project short-term impacts - the potential number of diabetes complications prevented, budget impact for the VA, and cost-effectiveness of different treatment strategies - that may inform VA diabetes treatment guidelines.

PI_NAMEs: RAGHAVAN, SRIDHARAN  (contact)

PROJECT_TERMS: Biostatistical Methods;budget impact;Caring;Characteristics;Clinical;clinical care;clinical trial participant;Clinical Trials;Comparative Effectiveness Research;Complications of Diabetes Mellitus;cost effectiveness;Cost Effectiveness Analysis;Data;Diabetes Mellitus;Eligibility Determination;Event;Glucose;Goals;Methods;Non-Insulin-Dependent Diabetes Mellitus;patient population;Pharmaceutical Preparations;Policies;prevent;randomized trial;randomized, clinical trials;Research Methodology;Subgroup;tool;Translating;Treatment Cost;treatment effect;Treatment Efficacy;treatment guidelines;treatment strategy;Veterans

PROJECT_TITLE: Transportability Methods to Extend Inferences from Contemporary Type 2 Diabetes Clinical Trials to Veterans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 ENDA-L (01)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Regenerative Medicine

ORG_CITY: DENVER

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: PROJECT NARRATIVE Inflammatory lung diseases affect over 1 million individuals in the United States annually and are responsible for high mortality associated with respiratory infections. We believe that lung immune cells, called macrophages, are responsible for promoting repair of the injured lung. This study will help identify whether all macrophages, or specific subsets participate in repair and identify mechanisms that drive recovery from lung inflammation.

PI_NAMEs: MOULD, KARA J (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Adult;Affect;Alveolar;alveolar epithelium;Apoptotic;Automobile Driving;Binding;Biological;Bronchoalveolar Lavage;cell growth;Cell Physiology;Cells;Cholesterol;Clinical;clinically relevant;Coculture Techniques;Data;Data Set;Dependence;differential expression;Epithelial Cell Proliferation;Epithelial Cells;epithelial repair;Epithelium;epithelium regeneration;Event;Exposure to;Gene Expression Profile;Genetic Transcription;Goals;Growth Factor;Hepatic;Heterogeneity;Human;Immune;Individual;Infiltration;Inflammation;Inflammatory;inflammatory lung disease;Injury;injury and repair;interstitial;Intrinsic factor;Link;Lipids;Lipopolysaccharides;Lung;Lung Diseases;lung health;lung repair;Macrophage;Measures;Modeling;Molecular;monocyte;mortality;Outcome;Paracrine Communication;Participant;Pathway interactions;Patients;Phagocytes;Population;Process;Production;promoter;Proteins;pulmonary function;Pulmonary Inflammation;Recovery;recruit;repair function;repaired;Research;Resolution;Respiratory Tract Infections;Role;Signaling Molecule;single-cell RNA sequencing;Site;Surface;System;Testing;Therapeutic;tissue repair;Transcript;transcriptomics;United States;Vascular Endothelial Growth Factors

PROJECT_TITLE: Reparative functions of human airspace macrophage subsets

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Prevention

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

ORG_STATE: CA

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) is a major public health burden, but an underlying cause, the deterioration of glu- cose-evoked insulin secretion by pancreatic β-cells, is poorly understood. The goal of this project is to uncover cellular mechanisms that could be treatment targets for preventing functional impairment of β- cells and the development of T2D.

PI_NAMEs: GERENCSER, AKOS A (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Address;ATP Synthesis Pathway;Beta Cell;Bioenergetics;Biological Assay;Cell Physiology;Cells;Cellular Metabolic Process;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Compensation;Coupling;Data;design;Deterioration;Development;diabetic;Disease;Energy Metabolism;Enzymes;Failure;Functional disorder;Functional impairment;Gene Expression;Gene Expression Profile;Genetic;Glucose;glucose metabolism;Goals;Human;Impairment;improved;Individual;individual variation;Insulin;insulin regulation;Insulin Resistance;insulin secretion;islet;Knock-out;Knowledge;Malonates;Mediating;Mediator;Membrane Potentials;Metabolic;Metabolic Activation;Metabolism;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Molecular;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear;Organ Donor;Outcome;Oxaloacetates;Pathway interactions;Peripheral;pharmacologic;Physiological;Play;Prediabetes syndrome;prevent;Preventive;Preventive therapy;Process;Public Health;Recovery;Regenerative capacity;Regulation;Replacement Therapy;Research;Respiration;response;restoration;Role;Structure of beta Cell of islet;success;Succinate Dehydrogenase;Supportive care;Up-Regulation;Work

PROJECT_TITLE: Novel components of mitochondrial regulation of insulin secretion in type 2 diabetes

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Nanotechnology;Rare Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE Ultrasound is among the world’s most widely used biomedical imaging technologies, but plays a relatively small role in molecular and cellular imaging due to a lack of contrast agents connected to specific aspects of cellular function such as gene expression and intracellular signaling. To address this limitation, we are developing acoustic biomolecules – proteins that can be imaged with ultrasound and serve as targeted nanoscale contrast agents and genetically encoded acoustic reporter genes. In this project, we will advance the engineering of these unique proteins and related ultrasound methods and apply them to imaging tumors and tumor-infiltrating immune cells.

PI_NAMEs: SHAPIRO, MIKHAIL  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Acoustics;Address;Air;Architecture;Area;Biology;biomedical imaging;Biomedical Research;Biosensor;Biotechnology;Brain Neoplasms;brain tumor resection;Calpain;cancer cell;cancer imaging;cell motility;Cell Physiology;Cell Proliferation;Cells;cellular imaging;Cellular immunotherapy;chimeric antigen receptor T cells;Clinic;Clinical;clinical development;clinical translation;clinically relevant;Code;commensal microbes;Contrast Media;cost;Cryoelectron Microscopy;Data;Detection;Diagnostic;Disease;Dose;Engineering;extracellular;Extravasation;Foundations;Future;Gases;Gene Expression;Genes;Genetic;hydrophilicity;Hydrophobicity;Image;imaging agent;imaging modality;Imaging technology;Immune;immunogenicity;Immunologic Monitoring;Immunotherapy;in vivo;in vivo imaging;Injectable;Internal Ribosome Entry Site;Intravenous;Label;Learning;Liver diseases;Mammalian Cell;Medicine;Methods;Microbe;migration;Molecular;molecular imaging;Molecular Structure;mouse model;Mus;nano;nanoscale;Nanostructures;Nature;neoplasm immunotherapy;neuro-oncology;neurosurgery;Paper;Peptide Hydrolases;Physiologic pulse;Play;Production;Proliferating;Proteins;Protocols documentation;real-time images;Reporter;Reporter Genes;Research;Resolution;response;Role;Science;Signal Transduction;Solid Neoplasm;Specificity;Standardization;Structure;Surface Properties;T-Lymphocyte;temporal measurement;Therapeutic;Tissues;translational applications;tumor;tumor xenograft;Tumor-infiltrating immune cells;Ultrasonics;Ultrasonography;ultrasound;uptake;Vesicle;Visualization;Work

PROJECT_TITLE: Biogenic Gas Nanostructures as Molecular Imaging Reporters for Ultrasound

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE (RELEVANCE) Receiver operating characteristic (ROC) analysis is an important methodology and cornerstone of medical imaging because it is the main tool for evaluating diagnostic performance of radiologists, medical devices, and new technologies in binary medical decision-making tasks (e.g., diagnosis of a patient as having a cancer vs. not). This proposal, which we call weighted ROC (WROC) analysis, innovates on basic ROC theory and practical applications alike by introducing a new case-weight factor, which will add flexibility to ROC analysis, improve clinical performance inference from laboratory studies, produce new ways to design better studies, and spawn new future research. WROC analysis will help make ROC analysis more general, broadly applicable, practical, accurate, precise, efficient, and user-friendly, and will enable it to make greater impact on evaluation and optimization of medical technologies and medical decision-making.

PI_NAMEs: JIANG, YULEI  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Algorithms;Case Study;Clinical;clinical practice;Communities;Computer software;Decision Making;Derivation procedure;design;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Dimensions;Evaluation;flexibility;foot;Friends;Health;improved;Individual;innovation;Knowledge;Laboratory Study;Malignant Neoplasms;mathematical algorithm;Mathematics;Maximum Likelihood Estimate;Medical;Medical Device;Medical Imaging;Medical Technology;Methodology;Methods;Modeling;new technology;novel;Patients;Performance;practical application;prospective;Publications;radiologist;Reader;Receiver Operating Characteristics;Research;Research Design;Research Personnel;ROC Curve;Sampling;simulation;software development;study characteristics;theories;tool;user-friendly;Validation;Weight

PROJECT_TITLE: Development of a new weighted ROC (WROC) analysis - Resubmission - 1

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: The economic and social impact of obesity has reached an all-time high of almost 1.4 trillion dollars in 2018, of which 40% is attributed to cardiovascular diseases. The current proposal will address a novel central mechanism that could be pharmacologically targeted for reducing or preventing the heightened risk for cardiovascular diseases in obese individuals.

PI_NAMEs: SUBRAMANIAN, MADHAN  (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Agonist;Anti-Hypertensive Agents;Astrocytes;Attention;Attenuated;autonomic reflex;biological adaptation to stress;blood pressure elevation;Brain;Brain Stem;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;Cell Aging;Cell Nucleus;cell type;Cells;Chronic;Classification;Conscious;Dasatinib;Data;economic impact;Event;experimental study;extracellular;first responder;Functional disorder;Gene Delivery;Gene Transfer;Generations;genetic manipulation;Glutamate Transporter;Glutamates;Healthcare;Heart failure;Homeostasis;Human;Hypertension;hypertension treatment;Impairment;In Vitro;Inflammation;Intervention;lipidomics;Mediating;Methods;Microglia;Monitor;mortality;mouse model;Mus;nanoparticle delivery;Nerve;Neuroglia;neuroinflammation;Neurons;new therapeutic target;novel;novel therapeutics;Obese Mice;obese patients;obese person;Obesity;Organ;overexpression;Overweight;oxidative DNA damage;Oxidative Stress;Oxidative Stress Induction;Pathogenicity;pharmacologic;Phenotype;Play;Population;pressure;Prevalence;prevent;Prevention;programs;Proteomics;Publishing;Quercetin;Reporting;Resistance;response;reuptake;Risk;Risk Reduction;Role;senescence;senescence associated secretory phenotype;senolytics;single cell sequencing;single-cell RNA sequencing;Social Impacts;Synapses;Techniques;Testing;Therapeutic;Time;Transgenic Mice;Vasomotor

PROJECT_TITLE: Brainstem glial senescence and dysfunction in obesity-induced hypertension

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Sleep Research

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Insomnia is prevalent and is associated with adverse health outcomes and increased risk for Alzheimer's disease related dementia. We propose to study the role of the autonomic nervous system and its relationship with sleep quality and cognition in mid to late life adults with insomnia and to identify novel pathophysiological mechanisms. The findings have the potential to lead to mechanistically targeted therapies for patients with insomnia who are at risk for dementia.

PI_NAMEs: GRIMALDI, DANIELA ;ZEE, PHYLLIS C. (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Adult;Age;age related changes;age related decline;Agonist;Alzheimer's disease related dementia;Alzheimer's disease risk;Arousal;Attention;Autonomic nervous system;Biological;Brain;Chronic Insomnia;Clonidine;Cognition;Cognitive;cognitive function;comorbidity;Control Groups;Data;dementia risk;Development;Electroencephalography;Episodic memory;executive function;Exposure to;Functional disorder;Health;high risk;Homeostasis;human old age (65+);Impaired cognition;Impairment;improved;innovation;insight;Intervention;Laboratories;late life;Light;Link;locus ceruleus structure;Measures;Medical;middle age;Modeling;Nervous System Physiology;Neuropsychology;noradrenergic;Norepinephrine;novel;older adult;Outcome;Participant;Patients;Performance;Peripheral;Pittsburgh Sleep Quality Index;Plasma;Play;poor sleep;presynaptic;Publishing;Quality of life;Randomized;Regulation;response;Risk;Role;sex;Short-Term Memory;Sleep;sleep behavior;Sleep Fragmentations;sleep onset;sleep quality;sleep regulation;Sleeplessness;System;targeted treatment;Testing;tool;Visit;young adult

PROJECT_TITLE: Noradrenergic Dysregulation, Sleep and Cognition in Older Adults with Insomnia

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE High levels of circulating androgens can negatively affect neuroendocrine reproductive hormone levels in females, yet the mechanisms and target cells by which androgens achieve these effects remain unknown. Indeed, hyperandrogenemia from exogenous androgens is a fundamental aspect of reproductive disruptions seen in transgender men (genetic females) and other clinical conditions, but little is known about how such disruptions are incurred. This proposal will utilize cutting edge molecular, genetic, and physiological techniques coupled with experiments in both genetic mouse models and human transgender subjects to delineate the specific cell targets and physiological mechanisms by which androgens can impact normal female reproductive hormone secretion and will improve understanding of androgen inhibition of neuroendocrine reproductive dysfunction.

PI_NAMEs: KAUFFMAN, ALEXANDER S (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Address;Affect;Amenorrhea;Androgen Receptor;Androgens;Anovulation;assigned female at birth;Basic Science;Behavioral;Biomedical Research;Brain;Caring;cell type;Cells;Characteristics;Clinical;Clinical Research;Clinical Sciences;Complement;Coupled;Data;Development;Dose;ESR1 gene;Estrogens;experience;experimental study;Exposure to;Family;Feedback;Female;Fertility;fertility preservation;Frequencies;Functional disorder;Future;gender affirmation;gender minority group;gender minority health;Gene Expression;Generations;Genetic;genetic manipulation;GNRH1 gene;Gonadotropins;Hormone secretion;Human;human female;human subject;Hyperandrogenemia;Hypothalamic structure;improved;in vivo;Individual;Infertility;innovation;interest;Intervention;Investigation;KISS1 gene;Knowledge;male;Masculine;Measures;men;Menstrual cycle;Menstruation;Messenger RNA;Methodology;Molecular;mouse model;Mus;neural;Neuroendocrine Cell;neuromechanism;Neurons;Neurosecretory Systems;nonbinary;novel;Ovarian;ovarian dysfunction;Ovarian hormone;Ovulation;Pathway interactions;patient population;Pattern;Periodicity;Persons;Physiologic pulse;Physiological;Population;Pregnancy;Production;Receptor Cell;Receptor Inhibition;Receptor Signaling;Reproduction;reproductive;reproductive axis;reproductive function;Reproductive Health;reproductive hormone;Research;restoration;Role;sex;Sexual and Gender Minorities;sexual minority group;sexual minority health;Site;Social Processes;Solid;steroid hormone;Techniques;Testing;Testosterone;Time;transcriptome;transcriptome sequencing;transcriptomics;transgender;transgender men;Transgenic Mice;Transgenic Organisms;Translating;Woman;women subjects;Women's study

PROJECT_TITLE: Androgen effects on the reproductive neuroendocrine axis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Orthopoxviruses;Rare Diseases;Vector-Borne Diseases;West Nile Virus;Zika Virus

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: NARRATIVE Accurate diagnosis is crucial for successful medical intervention in infectious diseases, but can be challenging due to shared symptoms among different infections and the rising prevalence of drug resistance. There remains a need to rapidly identify causative pathogens and choose appropriate treatments quickly given that prognosis can depend on the turnaround time between sample collection and diagnosis. In this competing renewal, we aim to build upon technology developed in our previous R01 to enable rapid, sensitive, and information-rich diagnosis of infectious diseases from clinical samples.

PI_NAMEs: ABATE, ADAM R. (contact)

PROGRAM_OFFICER_NAME: DYALL, JULIE

PROJECT_TERMS: Abate;accurate diagnosis;Address;Adoption;bacterial genome sequencing;Bacterial Infections;Bacterial Meningitis;bioinformatics tool;Biological Assay;Biological Markers;Cellular Assay;Central Nervous System Infections;Cerebrospinal Fluid;CLIA certified;Clinical;clinically actionable;clinically relevant;Collaborations;communicable disease diagnosis;Communicable Diseases;computerized tools;deep sequencing;Development;Diagnosis;Diagnostic;diagnostic tool;diagnostic value;digital;disease diagnostic;DNA;Doctor of Philosophy;Drug resistance;drug resistant pathogen;Emulsions;Ensure;experience;Family;Flaviviridae;Flavivirus;Flow Cytometry;Genome;genome sequencing;Genomics;Goals;Grant;Human;improved;in silico;Infection;Infectious Agent;Intervention;Laboratories;Medical;Meningitis;Methods;Microfluidics;Mission;Monkeypox;Morbidity - disease rate;new outbreak;next generation sequencing;novel diagnostics;Nucleic Acids;Orthopoxvirus;pathogen;Pathogen detection;pathogen genome;pathogenic virus;Pathogenicity;Patients;Physicians;Plasma;Prevalence;Prognosis;resistance gene;sample collection;Sampling;Selection for Treatments;single cell sequencing;Specimen;success;Symptoms;Technology;Time;Vesicle;Virulence Factors;Virus;West Nile virus;whole genome;Zika Virus

PROJECT_TITLE: Gigapixel Next-Generation-Sequencing: An Ultra-Sensitive Diagnostic for Infections of the CNS

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Lung

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Ciliated cells provide essential host defense through the clearance of inhaled contaminants out of the lungs by the directional movement of cilia. Abnormal cilia and ciliated cell loss precipitate and exacerbate chronic inflammatory airway diseases like cystic fibrosis, asthma and COPD. Here we study a Wnt cell signaling mechanism that ensures the generation of the correct number of functional ciliated cells with the aim of identifying novel therapeutic approaches to target ciliary dysfunction in chronic airway disease.

PI_NAMEs: VLADAR, ESZTER KATALIN (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Airway Disease;airway epithelium;airway inflammation;Asthma;base;beta catenin;Cell Culture Techniques;Cell Nucleus;Cells;Cellular biology;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;chronic rhinosinusitis;Cilia;cilium biogenesis;Clustered Regularly Interspaced Short Palindromic Repeats;Cystic Fibrosis;cytokine;Data;Disease;Ectopic Expression;Ensure;epithelial stem cell;Epithelium;experience;Failure;Felis catus;Fluorescence;Functional disorder;Generations;Goals;Health;Host Defense;Human;Impairment;In Vitro;Inflammation;Inflammatory;Inhalation;inhibitor;innovation;insight;Interleukin-1 beta;kinetosome;Knock-out;Knockout Mice;Knowledge;Label;Ligands;Lung;Maintenance;Mediating;Mediator;Methods;Modeling;Molecular;Molecular Target;Motility;mouse model;Movement;Mucociliary Clearance;Mus;mutant;novel;novel therapeutic intervention;Nuclear Import;Pathology;Pathway interactions;pharmacologic;Phosphorylation;Physiologic pulse;planar cell polarity;prevent;programs;Protein Isoforms;Publishing;recruit;Regulation;repaired;response;Role;Signal Transduction;Specific qualifier value;Specificity;Testing;therapeutic target;Tissues;Transgenic Mice;WNT Signaling Pathway;WNT4 gene;Work

PROJECT_TITLE: Canonical to noncanonical Wnt signaling switch in airway epithelial health and disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Emerging evidence implicates previously unknown glomerular endothelial lipid dysfunction as an important pathological process in the development of Alport syndrome. In this proposal we will investigate the role of lipid metabolism in the development of glomerular endothelial dysfunction and will use extracellular vesicles as a tool to re-establish functional homeostasis. Better understanding of the role of glomerular endothelium in the development of Alport pathology will facilitate the discovery of strategies to more effectively target the kidney for therapy.

PI_NAMEs: SEDRAKYAN, SARGIS  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;Acetyl-CoA Carboxylase;Affect;amniotic fluid derived stem cell;Biological;Caveolae;Cell Culture Techniques;cell injury;Cell membrane;Cellular biology;Cellular Metabolic Process;Chronic Kidney Failure;Collagen Type IV;Complex;Data;design;Deterioration;Development;Digestion;Disease;Disease Progression;Dose;End stage renal failure;Endocytosis;Endoplasmic Reticulum;Endothelial Cells;endothelial dysfunction;Endothelium;Enzymes;Etiology;experimental study;extracellular vesicles;fatty acid biosynthesis;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fatty Change;Fatty-acid synthase;fluorescence lifetime imaging;FRAP1 gene;Functional disorder;gain of function;gene repression;Genes;Genetic;Genetic Diseases;glomerular basement membrane;glomerular endothelium;glomerular filtration;Goals;Hereditary nephritis;Homeostasis;Human;improved;In Vitro;in vivo;Injury;insight;intravital imaging;KDR gene;Kidney;kidney biopsy;Kidney Failure;knock-down;Knock-out;Knowledge;Link;lipid metabolism;lipidomics;Lipids;loss of function;Lysosomes;Mediating;membrane assembly;Membrane Microdomains;Metabolic;Metabolic dysfunction;Mitochondria;Modeling;Molecular;Mus;Mutation;novel;oxidation;Palmitates;Pathogenesis;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Permeability;Phosphorylation;Physiology;PIK3CG gene;Play;podocyte;PPAR alpha;preservation;prevent;Proteinuria;Proteome;Publishing;Regulation;Reporting;Role;Scheme;Signal Transduction;stressor;System;Testing;Therapeutic;Time;tool;transcriptome;transcriptomics;Triglycerides;Vascular Endothelial Growth Factors;very low density lipoprotein triglyceride

PROJECT_TITLE: Glomerular endothelial damage: a new role of the lipids in Alport syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Boulder

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative Alzheimer's disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia are fatal, currently untreatable neurodegenerative diseases. We have identified a novel molecular mechanism, accumulation of double-stranded RNA, that may contribute to the neuronal pathology in these diseases. The proposed studies will test this hypothesis.

PI_NAMEs: HOEFFER, CHARLES A;LINK, CHRISTOPHER D. (contact);ZHANG, YONGJIE

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: adeno-associated viral vector;Adenoviruses;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Anti-viral Response;Antibodies;Autopsy;Biological Assay;Brain;Caspase;Cell Death Induction;cell type;Cells;Complement;Cultured Cells;Cytoplasm;Data;Deposition;Disease;Double Effect;Double-Stranded RNA;Engineering;Etiology;experimental study;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic Transcription;Gliosis;Goals;Hippocampus;Human;human induced pluripotent stem cells;immune activation;Immunofluorescence Immunologic;Immunoprecipitation;in vivo;in vivo evaluation;Induced pluripotent stem cell derived human neuron;Infection;Innate Immune Response;knock-down;Knock-out;lentivirally transduced;Lentivirus;Molecular;Motor Cortex;mouse model;Mus;Nerve Degeneration;neural;Neurodegenerative Disorders;neurodegenerative phenotype;neuroinflammation;neuron loss;Neuronal Dysfunction;Neurons;neuropathology;new therapeutic target;Normal Cell;novel;Nuclear;Pathologic;Pathology;Pathway interactions;Patients;Procedures;protein TDP-43;Proteins;Ribonucleases;RNA;RNA immunoprecipitation sequencing;RNA metabolism;Role;Sampling;Spinal Cord;tau Proteins;Testing;Tissues;Transcript;transcriptome;transcriptomics;Transgenic Mice;Viral;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Double-stranded RNA in neuronal cell death in Alzheimer's and related neurodegenerative diseases

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Headaches;Migraine;Neurosciences;Pain Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Migraine affects more than one in ten people in the US, yet we still do not understand basic features of this disease, like how a migraine attack starts. This proposal will study the origins of the migraine attack by focusing on the initiation of spreading depolarization (SD), the physiological correlate of the migraine aura, which in turn is the first measurable event in in a migraine attack. We will use a combination of imaging, electrophysiology, and genetic manipulation to examine the cerebral cortex at cellular resolution during the initiation of SD, hopefully generating novel insight into how an attack of migraine begins, and thus critical information on how to stop it.

PI_NAMEs: BRENNAN, KEVIN CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TITLE: Noncanonical glutamate signaling in the origins of the migraine attack

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Contact PD/PI: Anand, Kanwaljeet Singh Preschool children exposed to adverse childhood experiences (ACEs) and/or early life adversity (ELA) are likely to have worse physical and mental health across their lifespan, whereas positive childhood experiences (PCEs) can build resilience and prevent these outcomes. We plan to assess the interactions of ACEs, PCEs, parenting, and poverty on the social psychology of childhood and develop objective measures for stress dysregulation using hair cortisol as a chronic stress biomarker. These studies will address fundamental gaps in our current knowledge and establish a scientific framework to investigate the long-term effects of early childhood adversity, physical or emotional trauma, child maltreatment, or other adverse experiences in early childhood, as well as the preventive and protective effects of loving, nurturing, and consistent caregiving to children during their early childhood.

PI_NAMEs: ANAND, KANWALJEET S (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adrenal Glands;Adult;adverse childhood events;Adverse event;Affect;Age;aged;Alcohols;Algorithms;allostatic load;Attentional deficit;autism spectrum disorder;Behavioral;Biological Assay;Biological Markers;Brain;Cardiovascular system;caregiving;Child;Child Abuse and Neglect;Child Health;Child Rearing;Childhood;Chronic;Chronic stress;Classification;Cognitive;community partnership;COVID-19 pandemic;Data;Development;Diabetes Mellitus;Disease;disorder prevention;Drug abuse;early childhood;early life adversity;Ecology;Eligibility Determination;Emotional;emotional trauma;Emotions;Enrollment;Epidemiology;Ethnic Origin;Event;experience;Exposure to;Family;Growth;Hair;Health;Health Care Costs;health disparity;Homicide;Human;Hydrocortisone;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Immune system;Imprisonment;improved;Income;intervention program;Intervention Trial;Knowledge;Lead;Life;life span;Link;Long-Term Effects;longitudinal, prospective study;Love;Malignant Neoplasms;Measurement;Measures;Mediating;Mental Depression;Mental Health;Metabolic;Methodology;Modeling;Mood Disorders;multidisciplinary;National Institute of Child Health and Human Development;novel;Obesity;Outcome;Oxytocin;pandemic disease;pandemic stress;Parents;pediatric trauma;Phase;physical conditioning;Physiological;Pituitary Gland;poor health outcome;Poverty;Preschool Child;Prevalence;prevent;Preventive;programs;promote resilience;Property;protective effect;Psyche structure;Psychometrics;Psychopathology;psychosocial;Public Health;Publishing;Race;Regulation;Research;resilience;Respiratory Disease;Risk;Role;salivary assay;Sampling;screening;secondary analysis;self esteem;Severities;sex;Single Parent;social;social attachment;social disparities;social health determinants;Social isolation;Social Psychology;Stress;stress reactivity;stressor;Substance abuse problem;Suicide;Symptoms;System;Testing;Time;Toxic effect;Training;traumatic stress;Youth

PROJECT_TITLE: Do Hair Cortisol and Hair Oxytocin represent the Stressful and Supportive Experiences of Preschool Children?

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rheumatoid Arthritis

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE Arthritic pain often persists after the resolution of inflammation, yielding a chronic state in which the sensory neuron displays increases in at least four sodium channels and a decrease in at least one potassium channel, yielding a polyneuropathy. To advance our thinking that management of this early inflammation and late polyneuropathy pain state is optimized by addressing changes in not only one channel but several, we will use spinal delivery of the CRISPR-dCas9 platform to epigenetically regulate these channels, a strategy with clear implication for safely managing the chronic pain in the arthritic patient.

PI_NAMEs: YAKSH, TONY L. (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Accounting;Address;Adverse event;Afferent Neurons;allodynia;Amino Acid Sequence;Anti-Inflammatory Agents;Antibodies;Antigen-Antibody Complex;Appearance;Arthralgia;arthritic pain;Arthritis;Biological Products;Biology;Capsaicin;Cell Culture Techniques;Chronic;chronic pain management;Clustered Regularly Interspaced Short Palindromic Repeats;conditioned place preference;Coupled;design;dorsal horn;Down-Regulation;early onset;Electrophysiology (science);Engineering;Epigenetic Process;epigenome;Extravasation;Female;gabapentin;gene repression;Genes;Goals;Guide RNA;Homologous Gene;Human;Immune Targeting;improved;in silico;In Vitro;in vitro testing;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory pain;insight;joint inflammation;Joints;K/BxN model;knock-down;Life;male;Mediating;Membrane;Messenger RNA;Modeling;Modification;Motor;Mus;nerve injury;nerve supply;Neurons;Neuropathy;Nociception;Nociceptors;Nodose Ganglion;olfactory bulb;Pain;pain behavior;Pain management;pain model;patch clamp;Pathology;Patients;Peripheral;Persistent pain;Pharmaceutical Preparations;Pharmacology;Phase;Phenotype;Plasma;Play;Polyneuropathy;Population;Potassium Channel;pre-clinical;prevent;Protein Engineering;Quality of life;receptor;Regulation;Repression;Resolution;Retina;RNA;Rodent Model;Role;Safety;Serum;sex;side effect;Sodium Channel;Spinal;Spinal Anesthesia;Substance P;System;Therapeutic;Therapeutic Intervention;Thinking;Time;Tissue Harvesting;tool;Transcriptional Activation Domain;transcriptome sequencing;Transfection;urinary;Variant;vector;Viral Load result;Work

PROJECT_TITLE: NEURAXIAL AAVS TARGETING DRG CHANNELS INVOLVED IN CHRONIC POST INFLAMMATORY PAIN


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: NASHVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: TN

PHR: Myeloid malignancies are common among veterans, in whom there were over 2000 cases of myelodysplastic syndrome alone between 1996-2005. This incidence is only increasing as the median age of all veterans is ~65 years, and Vietnam veterans, the largest cohort of VA patients, reach their 70s, when myeloid malignancies peak in incidence. Myeloid malignancies find their origin in acquired mutations in hematopoietic stem cells. This project will first dissect the clonal and phenotypic identities of mutated stem and progenitor cells within the common myeloid malignancies of myelodysplastic syndrome and acute myeloid leukemia at single cell resolution. It will then determine how intracellular signals differ across clones to characterize the nongenetic causes of clonal dominance. Using cutting edge single cell techniques with computational analysis, we will link various multiomic datasets to establish a new framework for clonal discovery.

PI_NAMEs: FERRELL, PAUL B (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Age;Aging;antibody detection;Architecture;Blood typing procedure;Cell model;Cell Ontogeny;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clonal Evolution;Clonality;cohort;Computer Analysis;CRISPR/Cas technology;Cytometry;Data;Data Set;Disease Progression;DNA sequencing;Dysmyelopoietic Syndromes;Epigenetic Process;extracellular;FLT3 gene;Gene Mutation;gene regulatory network;Genetic Transcription;Genotype;Hematopoietic Neoplasms;Hematopoietic stem cells;Incidence;Inflammatory;Link;Malignant Neoplasms;Methylation;military veteran;Mitochondrial DNA;Modality;Molecular;Multiomic Data;mutant;Mutate;Mutation;mutational status;Myeloproliferative disease;non-genetic;Output;Patients;Pattern;Phenotype;Population;Property;Proteins;Recording of previous events;Resolution;response;Sampling;Secondary acute myeloid leukemia;Signal Transduction;single-cell RNA sequencing;stem;stem cells;Surface;Techniques;Testing;therapeutic target;tool;transcriptome;Veterans;Vietnam

PROJECT_TITLE: Dissecting Clonal Evolution of Myeloid Malignancies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 HEMA-G (01)]


NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Amyotrophic lateral sclerosis (ALS) and related motor neuron diseases affect more than 30,000 people in the United States, and 90% of ALS patients die within 5 years of diagnosis. It is well known that there is a strong genetic component to these degenerative diseases, yet many of the genetic causes remain poorly defined. The proposed studies will investigate the genetic functions of a gene ZNF106 newly understood to be involved in human ALS-like neurodegeneration to determine how ZNF106 mutations cause motor neuron degeneration.

PI_NAMEs: BLACK, BRIAN L (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Address;Adolescent;Affect;ALS patients;Amyotrophic Lateral Sclerosis;Binding;Biochemical;Categories;Cell Culture Techniques;Cell Nucleolus;cell type;Cells;Data;Degenerative Disorder;Diagnosis;Disease;early onset;falls;familial amyotrophic lateral sclerosis;G-Quartets;Generations;Genes;Genetic;genetic approach;genetic association;Histopathology;Human;Human Chromosomes;human disease;in vitro Assay;in vivo;Knock-in;Knock-in Mouse;Knock-out;Knockout Mice;Learning;loss of function;Maintenance;Maps;Modeling;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;neuroprotection;Nuclear;Orthologous Gene;Patients;Persons;Phenotype;Play;Predisposition;protein function;Proteins;RNA;RNA Binding;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Site;Skeletal Muscle;sporadic amyotrophic lateral sclerosis;Testing;United States;unpublished works;Variant

PROJECT_TITLE: Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Nutrition;Obesity;Prevention

PHR: PROJECT NARRATIVE Age-related eye disorders affect more than half of the elderly population, compromising their ability to perform daily activities. In this proposal, we will determine conserved genes that influence eye degeneration through their effects on diet, aging, and circadian clocks in the eye. These studies will provide insights into therapeutic targets to slow age-related decline in visual function and their detrimental effects on peripheral tissues.

PI_NAMEs: KAPAHI, PANKAJ  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Address;Affect;Age;age acceleration;age effect;age related;age related changes;age related decline;Aging;aging clocks;base;Behavioral;Blindness;Calories;Cell Physiology;chromatin immunoprecipitation;circadian;circadian pacemaker;Circadian Rhythms;circadian transcriptome;Cues;Darkness;Data Set;deep sequencing;Diabetic Retinopathy;Diet;dietary restriction;Disease;Elderly;Evolution;extend lifespan;Eye;Eye diseases;fly;Functional disorder;fundus imaging;gene conservation;Gene Expression;gene network;Genes;Genetic;Genetic Polymorphism;Genetic Transcription;genome wide association study;Goals;Health;healthspan;Homeostasis;Housing;Human;insight;Intervention;life span;lifestyle intervention;Light;Mediating;Molecular;molecular clock;Morbidity - disease rate;Morphology;mortality risk;Mus;novel;Nutrient;Obesity;older adult;Orthologous Gene;Outcome;Outcome Study;Output;Overnutrition;Pathway interactions;Periodicity;Peripheral;photoreceptor degeneration;Photoreceptors;Phototransduction;Pigments;Population;prevent;protective effect;response;Retina;Rhodopsin;Risk;Risk Factors;Role;senescence;systemic inflammatory response;therapeutic target;Tissues;transcription factor;transcriptome sequencing;transcriptomic profiling;Vision;Visual;visual photoreceptor;Visual System

PROJECT_TITLE: The role of diet and aging in photoreceptor homeostasis and visual function decline

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Even though most heart attack patients have underlying heart disease, not all patients with heart disease have a heart attack. This observation suggests that some of the biological mechanisms that establish and promote heart disease are different from those that cause a heart attack. By integrating various experimental approaches, this project will discover and validate novel genes that specifically increase risk of heart attack in heart disease patients but not heart disease itself.

PI_NAMEs: ALLAYEE, HOOMAN  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: 9p21;ABO blood group system;Address;Affect;Aorta;Apolipoprotein E;Atherosclerosis;atherosclerotic plaque rupture;Bioenergetics;Bioinformatics;Biological;Candidate Disease Gene;Cardiac;Carotid Stenosis;causal variant;Cause of Death;Cells;Chromosomes;Classification;clinically significant;cohort;Collaborations;comparative;Coronary Arteriosclerosis;Data;Development;Endothelin-1;Event;Exhibits;exome;experimental study;Extracellular Matrix;Follow-Up Studies;Foundations;functional genomics;gene discovery;Genes;Genetic;genetic analysis;genetic approach;Genetic Predisposition to Disease;genetic risk factor;Genetic study;genome wide association study;Genomics;Heart Diseases;Human;human model;in vivo;Individual;innovation;Lead;Lesion;Maps;Meta-Analysis;migration;Mitochondrial DNA;Molecular;mouse model;Mus;Myocardial Infarction;new therapeutic target;novel;Pathway interactions;Patients;Pattern;Ploidies;Probability;Production;rare variant;Regional Disease;Risk;Role;Rupture;Series;Signal Transduction;Smooth Muscle Myocytes;Societies;Stroke;Sudden Death;Surgical Models;Susceptibility Gene;Testing;therapeutic development;thrombotic;transcriptome sequencing;Validation;Variant

PROJECT_TITLE: Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Contraception/Reproduction;Genetics;Human Genome;Infertility;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE The repair of programmed DNA breaks by homologous recombination is essential for meiosis, the cellular process that produces sperm and eggs. This proposal addresses a critical gap in our understanding of meiotic recombination in mammals, the role of the breast cancer associated protein, BRCA2, which loads the central recombination enzyme RAD51 onto the ends of DNA breaks. Defects in BRCA2-mediated recombination are associated with infertility, pregnancy loss, congenital disease and ovarian insufficiency.

PI_NAMEs: HEYER, WOLF-DIETRICH ;HUNTER, NEIL  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Ablation;Address;Alleles;Antibodies;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Biology;BRCA2 gene;BRCA2 Protein;Cell division;Cell Physiology;Cells;Cellular biology;ChIP-seq;Chromatin;Chromosome Pairing;Chromosome Segregation;Chromosomes;Complex;Cre driver;Data;Defect;Development;Disease;DNA;DNA Double Strand Break;DNA Repair;Double Strand Break Repair;egg;Enzymes;Epitopes;Essential Genes;Event;Filament;gene function;Genetic;Genetic Crossing Over;Genetic Recombination;genome integrity;genome-wide;Genomics;Germ Cells;Growing Follicle;Haploidy;Histologic;Homologous Gene;homologous recombination;Human;Hybrids;Image;Immunofluorescence Immunologic;in vivo;in vivo evaluation;Infertility;insight;Invaded;Kinetochores;Knowledge;Length;LoxP-flanked allele;Maintenance;Malignant Breast Neoplasm;Mammals;Maps;Mediating;Meiosis;Meiotic Prophase I;Meiotic Recombination;Molecular;Mus;mutant;Mutant Strains Mice;Mutate;Nucleoproteins;Oocytes;Ovarian;ovarian reserve;Pathology;Pathway interactions;Pattern;Phenotype;Physiological;Play;Ploidies;Positioning Attribute;Pregnancy loss;primary ovarian insufficiency;Primordial Follicle;Process;Prophase;Proteins;Publishing;Rad51 recombinase;Reagent;Regulation;repaired;Reporting;Resolution;Role;segregation;Series;Site;Somatic Cell;Spatial Distribution;sperm cell;Spermatocytes;SPO11 gene;Spontaneous abortion;superresolution imaging;Testing;Time;tool;ultra high resolution

PROJECT_TITLE: Roles of BRCA2 in Mammalian Meiosis and Gamete Quality

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: Pasadena

ORG_NAME: DOHENY EYE INSTITUTE

PHR: Project narrative We will develop a high-resolution adaptive optics fluorescence lifetime imaging ophthalmoscope (AOFLIO) and use this instrument to characterize the fluorescence lifetime of fluorophores within individual cells or specific layers in the retina and its supporting retinal pigment epithelium (RPE) in the living human eye. Our study will provide precise localization of retinal and RPE metabolic function at the cellular level in normal human eyes with normal aging and age-related macular degeneration.

PI_NAMEs: FRASER, SCOTT E;SADDA, SRINIVAS R (contact);ZHANG, YUHUA LIANG

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: absorption;Achievement;adaptive optics;adaptive optics scanning laser ophthalmoscopy;Age;Age related macular degeneration;Aging;aging related;American;Blindness;Budgets;cell type;Cells;Central Nervous System Diseases;Characteristics;Clinical;Collection;Color;Complex;Databases;Development;Diagnosis;Disease;Ethnic Origin;Eye;Flavin-Adenine Dinucleotide;Fluorescence;fluorescence lifetime imaging;fluorophore;Fortification;Foundations;Functional disorder;Future;Ganglion Cell Layer;Gender;Health;Health Status;Histology;Human;human imaging;human subject;Image;image processing;Imaging Device;improved;in vivo;in vivo evaluation;in vivo imaging;Individual;Inner Plexiform Layer;instrument;Intraocular Lens Implantation;Investigation;Lateral;lens;Light;Lipofuscin;Longitudinal Studies;macula;Measurement;Measures;Metabolic;Microscopy;Mitochondria;Molecular;Monitor;Nerve Fibers;non-invasive monitor;normal aging;novel;Ophthalmoscopes;Ophthalmoscopy;Optics;outer plexiform layer;Oxidative Stress;Pathogenesis;Performance;Photons;Photoreceptors;Physiology;Property;quantitative imaging;Race;Resolution;Retina;Retinal Diseases;retinal imaging;Risk Factors;Role;Sensitivity and Specificity;Signal Transduction;Source;Speed;Structure of retinal pigment epithelium;Subcellular structure;Time;Tissues;Vitamin A

PROJECT_TITLE: In vivo Imaging of the Human Retina at the Molecular Level

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Human Genome;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: Project narrative: Infants born more than 3 months prematurely are at high risk for lung disease that often persists through childhood, manifests as wheezing or abnormalities in lung or heart function, and may represent subtypes of disease that cannot be discerned in the early neonatal intensive care unit (NICU) course. Genetics may play a role in contributing to these subtypes, but studies have been inconclusive because of the imprecise definition of lung disease in the NICU and insufficient numbers of participants. We are assembling almost 2000 former premature infants who were enrolled in studies in the NICU, who have genetic data available, and who are now enrolled in studies at school-age to: 1) use gene pathways to define these subtypes of lung disease; 2) predict longer-term cardiorespiratory outcomes early in the NICU course; and 3) understand the genetic mechanisms that determine these outcomes so that we might treat or prevent these lung diseases early on.

PI_NAMEs: HAMVAS, AARON  (contact);MOORE, PAUL E;TORGERSON, DARA

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Address;Adult;Age;Alveolar;Asthma;Bronchopulmonary Dysplasia;Candidate Disease Gene;cardiogenesis;Child;Child Health;Childhood;chronic respiratory disease;Clinical;Clinical Data;cohort;Corticotropin-Releasing Hormone;Data;data repository;Disease;disorder subtype;DNA;Early Diagnosis;Early Intervention;Echocardiography;Enrollment;Epidemiology;Epidermal Growth Factor;exome;extreme prematurity;Future;Genes;Genetic;genetic architecture;genetic association;Genetic Determinism;genetic information;Genetic study;Genetic Variation;genome wide association study;genome-wide;Genomics;Goals;Gonadotropins;heart function;Heterogeneity;high risk;improved;Individual;Infant;Inflammation;Intervention;Link;longitudinal analysis;Lung;Lung Diseases;Meta-Analysis;Methods;Morbidity - disease rate;Neonatal Intensive Care Units;neonatal lung disease;Newborn Infant;novel;Outcome;Participant;Pathway Analysis;Pathway interactions;personalized intervention;Phenotype;Physiological;Physiological Processes;polygenic risk score;Pregnancy;premature;Premature Infant;preterm newborn;prevent;preventive intervention;programs;Prospective cohort;Prospective Studies;pulmonary function;Pulmonary Hypertension;pulmonary vascular disorder;Recurrence;Research;resilience;respiratory;Respiratory Disease;Respiratory Insufficiency;respiratory morbidity;Retrospective cohort;reverse genetics;Risk;Sampling;School-Age Population;Signaling Protein;SNP array;Specific qualifier value;Spirometry;Statistical Data Interpretation;trait;Variant;Wheezing

PROJECT_TITLE: Long-term Endotypes of Prematurity Associated Respiratory Disease (LEOPARD)

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ORG_CITY: WASHINGTON

ORG_NAME: U.S. DEPT/VETS AFFAIRS MEDICAL CENTER

ORG_STATE: DC

PHR: Chronic pain, that is, pain that persists or recurs for 3 months or more, affects 20 % of adults in the United States and contributes to an annual economic cost of greater than $600 billion and is more prevalent among Veterans compared to non-Veterans with significantly higher rates of chronic pain in women veterans. Using noninvasive techniques to change the function of brain areas that are involved in chronic pain is one approach to developing treatments for chronic pain conditions. A small area of the brain called the insula is activated in chronic pain conditions. This study tests a new noninvasive technique called low intensity focused ultrasound (LIFU) as a way to inhibit the insula and determine whether this causes individuals with chronic pain to have a reduced response to painful stimuli and whether activity in the insula is decreased after LIFU. Results from this study could provide important information on how brain function changes with chronic pain disorders and may lead to improved treatments for chronic pain.

PI_NAMEs: LEE, MARY  (contact)

PROJECT_TERMS: Address;Adult;Affect;Affective;American;Anterior;Area;Auditory;Awareness;Back;behavior measurement;Bilateral;blood oxygen level dependent;Brain;Brain region;central sensitization;chronic back pain;chronic pain;chronic pain management;chronic pain patient;Chronic pain syndrome;chronic painful condition;clinical pain;clinical predictors;Code;conditioned pain modulation;cost;Data;Diagnosis;economic cost;Economics;effective therapy;eligible participant;Emotions;Epidemic;Event;Evoked Potentials;expectation;experience;Focused Ultrasound;Functional Magnetic Resonance Imaging;Human;improved;Individual;Insula of Reil;Knowledge;Laboratories;Link;Measures;Methods;military veteran;millimeter;multiple datasets;neural;Neurologic;neuroregulation;Neurosurgical Procedures;Nociception;noninvasive brain stimulation;Nonpharmacologic Therapy;novel;Opioid;Outcome;Pain;Pain intensity;Pain management;pain processing;pain reduction;Pain Threshold;Patients;Pattern;Pharmacological Treatment;Phenotype;Placebos;Population;Process;Public Health;Recurrence;Resolution;response;Rest;Role;Sensory;Site;social;somatosensory;Specificity;Spinothalamic Tracts;Stimulus;Structure;Symptoms;Techniques;Testing;Therapeutic;Transcranial magnetic stimulation;United States;Veterans;Woman

PROJECT_TITLE: Low Intensity Focused Ultrasound for Chronic Pain: High Resolution Targeting of The Human Insula

STUDY_SECTION_NAME: Special Emphasis Panel[ZRD1 NURP-N (01)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Project Narrative Viral persistence due to low antiretroviral (ARV) penetration in secondary lymphoid tissues (SLTs) and poor adherence to daily ARV regimen remain major barriers to achieving a functional cure for HIV. We want to develop “stealth” long-acting lipid polymeric nanoparticles (GM3-PLA-NPs) that can potentially increase ARV entry and retention in SLTs by forming cellular drug depots in CD169+ macrophages. Our proposed studies will investigate the stealth and biodistribution mechanisms of GM3-PLA-NPs to elucidate new strategies for targeted delivery of safe long-acting drugs in the SLTs and hence aid in the development of nanotherapeutics for prevention and treatment of HIV.

PI_NAMEs: FOFANA, JOSIANE  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Address;Adherence;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Binding;Biodistribution;Biotin;CD4 Positive T Lymphocytes;Cell membrane;Cell surface;Cell Survival;Cells;Chronic;Coculture Techniques;combinatorial;comorbidity;cytokine;Data;Dendritic Cells;design;Development;Disease;Disseminated Malignant Neoplasm;Dose;drug action;Dyes;Exposure to;extracellular;Failure;Flow Cytometry;Gangliosides;Goals;HIV;HIV therapy;HIV-1;Image Cytometry;immune activation;immunoregulation;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;Inflammatory Response Pathway;Injections;innovation;Integrase Inhibitors;Label;Lectin Receptors;Ligase;Link;Lipid Bilayers;Lipids;live cell imaging;Lymphoid Tissue;Macrophage;Measures;Mediating;medication compliance;Membrane;monocyte;Morbidity - disease rate;mortality risk;Mus;Myeloid Cells;nanoformulation;nanoparticle;nanopolymer;nanotherapeutic;non-nucleoside reverse transcriptase inhibitors;nonhuman primate;novel strategies;Nucleosome Core Particle;Oral;Patients;Penetration;Pharmaceutical Preparations;Phenotype;Plasma;poly(lactic acid);Polymers;Predisposition;preservation;prevent;Prevention;Property;Protein-Protein Interaction Map;Regimen;response;Risk;Role;Secondary to;Sialic Acids;Site;Spatial Distribution;spectrograph;Synapses;T-Lymphocyte;targeted delivery;Testing;Therapeutic;Time;Tissues;Toxic effect;transmission process;uptake;Viral;viral rebound;viral transmission;virological synapse;Virus

PROJECT_TITLE: Dual antiretroviral loaded nanoparticles for long-acting suppressive HIV therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F17A-H(20)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE    Although immunotherapy has had remarkable successes in the treatment of cancer, it only benefits a minority of  cancer patients, and we do not know how to rationally combine immunotherapy with other treatments. Advances  have been difficult in part because we do not have animal models that respond well to immunotherapy. The goal  of  this  project  is  to  develop  better  mouse  cancer  models  that  harbor  both  the  driver  and  passenger  mutations  seen in human cancers, and use this to understand mechanisms of response and resistance to immunotherapy  and rationally design more effective combination immunotherapy strategies.

PI_NAMEs: WHITE, EILEEN P. (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Affect;Animal Cancer Model;Animal Model;anti-tumor immune response;Antibodies;Bypass;Cancer Burden;Cancer Model;Cancer Patient;cancer therapy;cancer type;checkpoint therapy;Clinic;Clinical;Clinical Trials;Combination immunotherapy;Combined Modality Therapy;CTLA4 gene;Defect;Development;DNA Polymerase III;DNA-Directed DNA Polymerase;Generations;Genetically Engineered Mouse;Genome;Germ Lines;Goals;Growth;Hand;Human;Immune;immune activation;immune checkpoint;immune checkpoint blockade;Immune response;Immune system;Immunocompetent;immunogenic;Immunotherapy;Induced Mutation;Knowledge;KRASG12D;Link;Lung;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;Melanoma;Minority;Mismatch Repair;Mitochondria;mitochondrial genome;Modeling;mouse model;Mus;Mutagenesis;Mutation;Nature;neoantigens;nonsynonymous mutation;novel;Nuclear;Oncogene Activation;Oncogenes;Oncogenic;patient population;Patient-Focused Outcomes;Patients;Peptides;Phenotype;Physiological;Polymerase;Predisposition;programmed cell death protein 1;rational design;Resistance;response;Signal Transduction;Skin;Solid Neoplasm;Somatic Mutation;Specimen;success;T-Lymphocyte;targeted treatment;Testing;Translating;treatment response;treatment strategy;tumor;tumor growth;Tumor Immunity;Wild Type Mouse

PROJECT_TITLE: Impact of mutation burden on cancer growth and the immune landscape

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Cancer;Prostate Cancer;Radiation Oncology;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Urologic Diseases

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Narrative We recently identified a novel mitochondrial signaling axis centered on MnSOD-K68 which, when its normal acetylation status is altered, disrupts cellular metabolism, leading to aberrant ROS levels (Zhu et al, 2019). This data has been extended to show that LNCaP-MnSODK68Q cells exhibit increased HIF2α, shown to promote a stemness-like phenotype, and two stem cell biomarkers, SOX2, and Oct4, consistent with stemness properties. Thus, is the disruption of cell metabolism surrounding MnSOD-K68-Ac a potential mechanism for radiation resistance as well as enzalutamide resistance and potential molecular target for novel therapies?

PI_NAMEs: GIUS, DAVID  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Acetylation;Allografting;androgen deprivation therapy;Antioxidants;Appearance;Biology;Cell Reprogramming;Cells;Cellular Metabolic Process;Chemical Agents;Chemicals;ChIP-seq;Clinical;Clinical Research;Compensation;Complex;Data;Development;Drug Metabolic Detoxication;enzalutamide;Exhibits;Exposure to;Genes;Genetic;Goals;Grant;Growth;high risk;In Vitro;in vivo;in vivo Model;Ionizing radiation;knock-down;Link;LNCaP;Lysine;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Measures;men;Metabolic;Metabolism;Methods;Mitochondria;mitochondrial metabolism;Modeling;molecular marker;Molecular Target;monomer;mouse model;mutant;Nature;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Organoids;Paper;patient derived xenograft model;Peroxidases;Phenotype;Process;Property;Prostate;prostate cancer cell;Proteins;radiation resistance;Reactive Oxygen Species;Recurrence;Reporter;Research;Resistance;Role;Signal Transduction;SOD2 gene;stem cell biomarkers;stemness;Superoxides;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Time;tissue culture;Tissue Recombination;transcriptome sequencing;tumor;tumor growth;Tumor Suppressor Proteins;vector

PROJECT_TITLE: Lineage Plasticity, due to Disruption of MnSOD Biology, drives resistance to Ionizing Radiation / Androgen Deprivation Therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: The overall goal of the BrainMap Project is to provide the human neuroimaging community with curated data sets, metadata, computational tools, and related resources that enable coordinate-based meta-analyses (CBMA), meta-analytic connectivity modeling (MACM), meta-data informed interpretation (“decoding”) of imaging results, and meta-analytic priors for mining (including machine learning) primary (per-subject) neuroimaging data.

PI_NAMEs: FOX, PETER THORNTON (contact)

PROGRAM_OFFICER_NAME: BENNETT, YVONNE MARIE

PROJECT_TERMS: 3-Dimensional;Address;biomarker discovery;Brain Mapping;case control;Categories;Code;Cognition Disorders;cognitive neuroscience;cohort;Communities;Computer software;computerized tools;connectome;Data;Data Analyses;Data Set;data submission;data tools;data visualization;Databases;design;Diagnostic;Disease;disease model;Educational workshop;Equation;experimental study;Funding;Goals;graph theory;Guidelines;hemodynamics;Human;Image;independent component analysis;Java;Learning;learning materials;lectures;Location;Machine Learning;Mango - dietary;Manuals;Mental disorders;Meta-Analysis;Metabolic;Metadata;Methods;Mining;Modeling;morphometry;Multivariate Analysis;network models;neuroimaging;Output;Parameter Estimation;Peer Review;Phase;Physiology;Plug-in;Property;Publications;Publishing;Regional Disease;Research Domain Criteria;Resources;Retrieval;simulation;Site;Software Framework;Surface;Symptoms;Taxonomy;Texas;Training;Uncertainty;Validation;webinar

PROJECT_TITLE: Meta-analysis in human brain mapping


FUNDING_MECHANISM: OTHERS

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: Exercise is an evidence-based intervention for the management of chronic conditions, yet the majority of US adults, including Veterans, are inactive. Telehealth is critically important for providing care to Veterans because it increases access and flexibility. Group telehealth exercise programs combine the benefits of group exercise sessions, such as social support, and telehealth technology. Exercise programs designed to address the different skills needed for exercise initiation and exercise maintenance are critical to ensure sustained exercise participation. This project addresses the high prevalence of inactivity among Veterans. Creation of a group telehealth exercise program that can be widely disseminated and implemented will not only meet physical activity guidelines but will also improve the health and quality of life for Veterans by reducing the burden of health conditions improved with participation in exercise.

PI_NAMEs: ABBATE, LAUREN M (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Administrator;Adult;Ambulatory Care Facilities;Cardiac;care delivery;career;Caring;Characteristics;Chronic;Chronic Disease;Chronic lung disease;Communities;contextual factors;Data;Data Collection;Degenerative polyarthritis;design;Development;dissemination science;effectiveness testing;Ensure;Environment;Equipment;evidence base;Evidence based intervention;Exercise;exercise intervention;exercise program;exercise training;experience;Feedback;flexibility;Focus Groups;formative assessment;Future;Guidelines;Health;health care availability;Health Technology;Healthcare;High Prevalence;Home;human old age (65+);Human Resources;implementation evaluation;implementation science;implementation trial;Improve Access;improved;Individual;innovation;Instruction;instructor;Integrated Health Care Systems;Internet;Intervention;Interview;Lower Extremity;Maintenance;Mentorship;Methodology;Methods;Modeling;Monitor;multidisciplinary;Participant;Phase;Physical activity;Physical Function;pilot trial;Population;Practical Robust Implementation and Sustainability Model;prevent;program dissemination;programs;Provider;Public Health;pulmonary rehabilitation;Qualitative Methods;Quality of life;Randomized;Recommendation;remote delivery;Research;Research Personnel;Resources;response;Site;skills;Social support;stakeholder perspectives;Surveys;Technology;telehealth;Text Messaging;therapy development;Training;Translating;trial design;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Expanding Exercise Programming for Veterans Through Telehealth

STUDY_SECTION_NAME: Research Career Scientist[MRA0]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences

PHR: Project Narrative Alzheimer’s disease is a devastating neurodegenerative disease that has a long “preclinical” stage in which pathological processes have begun but overt cognitive impairment is absent. Understanding mechanisms of initial neuronal changes and corresponding effects on memory abilities is critical for distinguishing between normal and pathological aging, and to improve risk prediction models that can be applied during the preclinical stage of AD. By combining cognitive neuroscience approaches with biofluid/PET quantification of disease, our research program will make significant contributions towards understanding early disease and cognitive aging.

PI_NAMEs: MORMINO, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Age;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;angular gyrus;Area;Biological Markers;Brain;Brain region;Cerebrospinal Fluid;Classification;Clinical;clinically significant;Cognitive aging;cognitive neuroscience;cognitive testing;cohort;Collection;Data;Data Collection;Dementia;Deposition;Development;Disease;eligible participant;Enrollment;entorhinal cortex;Episodic memory;ethnoracial;Failure;Functional disorder;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Goals;Hippocampus;Human;Image;imaging modality;Impaired cognition;improved;Individual;Individual Differences;innovation;insight;Lateral;Ligands;Magnetic Resonance Imaging;Measurement;Measures;medial temporal lobe;Memory;Memory impairment;Memory Loss;memory process;memory retrieval;Modality;Modeling;Molecular;Neurobehavioral Manifestations;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neurons;next generation;normal aging;older adult;Older Population;Participant;Pathologic Processes;pathological aging;Pathology;Pattern;Performance;Phenotype;Positioning Attribute;Positron-Emission Tomography;pre-clinical;Process;programs;Proteomics;Research;Resolution;Retrieval;risk prediction;risk prediction model;Sampling;Senile Plaques;Signal Transduction;Site;Spinal Puncture;structural imaging;Structure;tau Proteins;Temporal Lobe;Testing;Thick;Time;ultra high resolution;Visit;Visual;Work

PROJECT_TITLE: Hippocampal-dependent memory decline in aging and early Alzheimer's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

PHR: PROJECT NARRATIVE The long-term goal of PREP@UCD is to increase diversity in the biomedical science workforce. Broadening inclusion will lead to diverse perspectives and scientific approaches, which is expected to build capacity for scientific breakthroughs with positive implications for biotechnological and public health outcomes.

PI_NAMEs: CHIU, JOANNA CHUNGYEN (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: academic preparation;Area;Award;base;Benchmarking;Biomedical Research;Biotechnology;California;career;career development;Color;Communication;Communities;Country;Coupled;Critical Thinking;design;Development;Development Plans;disadvantaged background;Doctor of Philosophy;Doctor's Degree;doctoral student;education research;Educational workshop;empowerment;Engineering;Enrollment;Environment;equity, diversity, and inclusion;Ethics;Exercise;experience;Exposure to;Faculty;Fellowship;First Generation College Students;Fostering;Funding;Future Generations;Goals;graduate school;graduate student;Grant;Individual;innovation;Institution;Interview;Journals;Knowledge;Laboratories;laboratory experiment;Laboratory Research;Latinx;Learning;Life;Literature;marginalized population;Medicine;member;men;Mentors;Mentorship;oral communication;Outcome;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Problem Solving;programs;Public Health;Publications;Qualifying;Readiness;Recommendation;Reproducibility;Research;Research Ethics;Research Personnel;Research Proposals;role model;Science;Scientist;Self Assessment;Self Perception;skills;Social skills development;student retention;Students;success;supportive environment;symposium;Technical Expertise;Testing;Time;Training;Transcript;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Academy of Sciences;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Postbaccalaureate Research Education Program at UC Davis

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: This R25 renewal application supports an innovative skills development program to educate the current nursing workforce to meet the nation's need for palliative care in oncology. By utilizing a skills-based innovative program to educate Advanced Practice Registered Nurses (APRNs), this proposal will equip and expand the nursing workforce to meet a critical need for palliative care in oncology.

PI_NAMEs: FERRELL, BETTY R (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Advanced Practice Nurse;Cancer Center;Cancer Patient;care providers;career networking;Caring;Clinical Cancer Center;Clinical Oncology;Clinical Practice Guideline;Collaborations;Communities;community setting;Comprehensive Cancer Center;Diagnosis;Discipline of Nursing;Disease remission;Educational Curriculum;Educational workshop;end of life care;experience;Family;Funding;General Practitioners;Guidelines;improved;innovation;Institution;Knowledge;Leadership;Long Term Survivorship;medical specialties;Modeling;National Cancer Institute;Nurse's Role;Nurses;Nursing Education;Oncology;Oncology Nurse;Organizational Change;Outcome;palliative;Palliative Care;Palliative Care Nursing;Participant;Patient Care;Patients;Peer Review;Process Measure;Program Development;programs;Publications;recruit;Recurrent disease;Registered nurse;Research;Research Personnel;Resources;skill acquisition;skills;skills training;success;System;systematic review;Testing;Training;Training Programs;Underrepresented Minority

PROJECT_TITLE: Preparing Oncology Advanced Practice Nurses as Generalists in Palliative Care

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Understanding the mechanisms of protein synthesis, or translation, is crucial to connecting genotype to phenotype in all forms of life. The project areas described in this proposal will reveal fundamental aspects of translation control in humans. In the long term, understanding translation control will provide a foundation for applications in human therapeutics, including targeting “undruggable proteins” and cellular immunotherapy.

PI_NAMEs: CATE, JAMIE H (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Affect;Area;Back;Behavior;Binding;Biochemical;Cells;Cellular immunotherapy;design;drug discovery;drug-like compound;Elements;Engineering;Eukaryota;Eukaryotic Initiation Factor-3;experimental study;Foundations;Future;Genotype;Glean;Human;human disease;improved;insight;interest;Investigation;Life;Maps;Messenger RNA;Molecular;Pathway interactions;Peptide Initiation Factors;Phenotype;polypeptide;Process;Protein Biosynthesis;Proteins;Quality Control;Ribosomal Frameshifting;Ribosomes;RNA;Role;small molecule;Speed;Structure;T cell regulation;T-Cell Activation;T-Cell Development;T-Cell Receptor;Therapeutic;Tissues;Trans-Activators;Translation Initiation;Translational Regulation;Translational Repression;Translations

PROJECT_TITLE: Mechanisms of Translation Control in Humans

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The proposed research evaluates immunity induced by the yellow fever vaccine 17D in humans. This knowledge is critical to understanding the determinants and correlates of yellow fever virus immunity as well as effective evaluation and improvement of this vaccine that is critical to control this globally important disease. The results of this project are highly and directly relevant to the NIH’s mission fostering innovative research strategies to reduce the burden of illness and disease.

PI_NAMEs: MESSER, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: FLORESE, RUTH HUAB

PROJECT_TERMS: Acute;adaptive immune response;Address;Adult;Aedes;Africa;African;Antibodies;antibody detection;Antibody titer measurement;Antibody-mediated protection;Antigens;arthropod-borne;Attenuated;Attenuated Live Virus Vaccine;Attenuated Vaccines;booster vaccine;Brazil;burden of illness;Cells;Cessation of life;cohort;Country;critical period;Cross-Sectional Studies;Culicidae;Data;Dengue Virus;Disease;Disease Outbreaks;Dose;Enrollment;Evaluation;falls;Flavivirus;Fostering;Foundations;Frequencies;Future;future outbreak;health organization;Heterogeneity;Human;human pathogen;Immune;immune activation;Immune response;Immunity;immunogenicity;Immunologic Markers;improved;Individual;Infection;Innate Immune Response;innovation;Kinetics;Knowledge;Long-Term Effects;Mass Vaccinations;Memory B-Lymphocyte;Mission;Modeling;mortality;Nail plate;neutralizing antibody;nonhuman primate;pathogenic virus;Phase I/II Clinical Trial;Policies;pressure;prospective;Prospective Studies;prototype;Public Health;Recommendation;Recording of previous events;recruit;Research;response;Safety;secondary analysis;seroconversion;seropositive;serosurvey;South Africa;South America;Surveys;Symptoms;Testing;Time;transmission process;United States National Institutes of Health;Vaccinated;Vaccination;Vaccine Antigen;vaccine immunogenicity;Vaccinee;Vaccines;Viral Antibodies;Viral Load result;Viral Vaccines;Viremia;Virus;Yellow Fever;Yellow Fever Vaccine;Yellow fever virus;Zika Virus

PROJECT_TITLE: Long Term Immunity Following Yellow Fever Vaccination

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: TUCSON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative – Public Health Relevance Statement This project will develop a personalized, non-invasive hippocampal stimulation protocol and determine its therapeutic effect on memory function and brain plasticity. We will apply this brain stimulation therapy to older adults at high risk of developing Alzheimer's disease in order to provide early intervention in attenuating neurodegeneration. !

PI_NAMEs: CHOU, YING-HUI  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: active method;Adult;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;amnestic mild cognitive impairment;Animal Model;Attenuated;Behavioral;Brain;brain magnetic resonance imaging;Brain region;Brain-Derived Neurotrophic Factor;clinical practice;Clinical Trials;cognitive function;comparative efficacy;Cross-Over Studies;Data;Development;Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;Dose;Double-Blind Method;Early Intervention;Enrollment;experience;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Genetic Polymorphism;high risk;hippocampal atrophy;Hippocampus;Human;image guided;Impaired cognition;Impairment;improved;Individual;innovation;Intervention;Knowledge;Learning;Magnetic Resonance Imaging;Maps;Measures;Medical;Memory;Methodology;Methods;Nerve Degeneration;Neurons;Neuropsychology;neuroregulation;noninvasive brain stimulation;novel;older adult;Outcome Measure;Participant;Pathology;Patients;Physiologic pulse;Population;precision medicine;preclinical study;predicting response;predictive modeling;prodromal Alzheimer's disease;Protocols documentation;public health relevance;Publishing;Randomized;recruit;Refractory;repetitive transcranial magnetic stimulation;Research;Rest;sex;Site;Statistical Models;Synaptic plasticity;Techniques;Testing;Therapeutic Effect;tractography;Treatment Efficacy;treatment response;treatment strategy

PROJECT_TITLE: Enhancement of Hippocampal Plasticity Using Repetitive Transcranial Magnetic Stimulation


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative Genomically unstable cancers such as breast and ovarian cancers are hard to treat due to their ongoing accumulation of copy number aberrations (CNAs) which leads to intratumoral heterogeneity. New single-cell whole genome sequencing (scWGS) methods such as direct library preparation (DLP) can profile CNAs at single-cell resolution, providing new insights on mutational processes and clonal competition within tumors. While previous scWGS analysis has focused on non-replicating cells, this proposal aims to use the S-phase cells captured in DLP libraries to predict clonal proliferation rates and determine the role of aberrant DNA replication across cancers of varying mutational processes.

PI_NAMEs: WEINER, ADAM CLAYTON (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Basic Science;Bayesian Modeling;Biological Markers;BRCA1 gene;BRCA2 gene;cancer cell;cancer therapy;Cell Count;Cell Cycle;Cell Line;cell type;Cells;chemotherapy;Clinical;Clinical Management;Clonal Evolution;computer framework;Computing Methodologies;Data;Data Set;daughter cell;Development;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;drug development;Drug resistance;drug sensitivity;Ensure;Evolution;Exposure to;Fire - disasters;fitness;Genes;Genetic;genetically modified cells;Genome;genome sequencing;Genomic Instability;Genomics;Goals;Grant;Heritability;Heterogeneity;improved;inhibitor;insight;Libraries;Literature;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Methods;Modeling;Mutation;Neoplasm Metastasis;next generation;Parents;Pathologist;patient derived xenograft model;patient stratification;Patients;Pattern;Phenotype;Phylogenetic Analysis;Platinum;Positioning Attribute;Preparation;Process;Proliferating;Property;prospective;Proxy;replication stress;Research Personnel;Resolution;response;Role;S phase;S-Phase Fraction;Sampling;Series;Somatic Mutation;Stress;stressor;targeted treatment;Technology;Testing;therapeutic development;Time;TP53 gene;treatment response;tumor;tumor heterogeneity;whole genome;Work

PROJECT_TITLE: Quantifying replication dynamics to predict clonal evolution and drug sensitivity in cancer cells using single-cell whole genome sequencing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Physical Activity;Prevention;Rehabilitation;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Cardiovascular disease is the primary cause of non-cancer morbidity and mortality among cancer survivors; however, standard of care strategies to prevent cardiovascular disease do not exist. We propose to evaluate the effects of aerobic exercise therapy (AT) program length and volume on cardiorespiratory fitness (CRF) response rate and other pertinent outcomes in EBC. Results from this investigation will identify the AT regimen that maximizes CRF response rate and other clinically relevant endpoints in EBC, and ultimately will inform policy, evidence-based guidelines, and standard clinical care.

PI_NAMEs: SCOTT, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TERMS: Address;Adjuvant Therapy;Adverse event;Aerobic Exercise;Age;arm;attentional control;Biological;Blood Vessels;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer therapy;Cancer Survivor;Cardiac Output;Cardiopulmonary;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder risk;Cessation of life;Classification;Clinical;clinical care;clinically relevant;cohort;Common Terminology Criteria for Adverse Events;cytotoxic;Data;Diagnosis;Dose;effective therapy;efficacy testing;Evaluation;Event;evidence based guidelines;exercise physiologist;exercise program;Exercise Therapy;follow-up;Frequencies;functional improvement;Heart;Home;improved;instrument;inter-individual variation;Interruption;Intervention;Investigation;Length;Life Style;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Masks;Measurement;Measures;Modification;Monitor;Morbidity - disease rate;mortality;Muscle;novel;Oncology;Outcome;Oxygen;Oxygen Consumption;Participant;Patient Outcomes Assessments;Patient Self-Report;Peripheral;Phase;Phase II/III Trial;Physiological;Policies;Population;prevent;primary endpoint;programs;Quality of life;radiation-induced injury;Random Allocation;randomized trial;Randomized, Controlled Trials;Regimen;Reporting;response;Safety;Sampling Studies;Skeletal Muscle;standard of care;Stretching;Survivors;System;tele-exercise;Testing;therapy adherence;Time;treadmill;treatment response;treatment strategy;trial design;Venous;virtual;Woman;Work

PROJECT_TITLE: A Randomized Trial to Minimize Non-Response to Aerobic Training in Operable Breast Cancer

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health as it is expected to identify novel epigenetic predictors and targets of stress-associated coronary heart disease (CHD), thereby opening new horizons towards personalized interventions that can beneficially modulate the epigenome of individuals experiencing high stress levels and CHD risk. These expected contributions are relevant to NHLBI’s mission as they have the potential to enhance prevention and treatment of CHD, which is the single leading cause of death in the United States.

PI_NAMEs: ZANNAS, ANTHONY S. (contact)

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Age;Alcohol consumption;Atherosclerosis;Biological Response Modifiers;Blood Cells;Body mass index;Cause of Death;Cell model;Cell Physiology;cell type;Cells;Chemicals;cohort;Cohort Studies;Complex;Computing Methodologies;Coronary heart disease;Data;Disease Outcome;DNA;DNA Methylation;Environment;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Ethnic Origin;Ethnic Population;Exhibits;experience;Exposure to;FOXP1 gene;Genes;Genetic;Genetic Code;Genomics;Goals;Health;heart disease prevention;heart disease risk;Hormones;Human;Immune;immune function;Individual;Inflammation;Inflammatory;innovation;insight;Investigation;Jackson Heart Study;Knowledge;Link;Macrophage;Methylation;methylation pattern;methylomics;Mission;Modernization;Modification;Molecular;Molecular Target;monocyte;Multi-Ethnic Study of Atherosclerosis;National Heart, Lung, and Blood Institute;novel;Outcome;Participant;Pathogenesis;Pattern;peripheral blood;personalized intervention;Phenotype;Physiological;prevent;Prevention;Process;programs;Psychosocial Stress;Public Health;Race;racial population;Research;Risk;Risk Factors;sex;Shapes;Signal Transduction;Site;Smoking;Societies;socioeconomics;Stress;systemic inflammatory response;Testing;TNF gene;Trans-Omics for Precision Medicine;United States;Whole Blood;Women's Health;Work

PROJECT_TITLE: Epigenetic mechanisms linking psychosocial stress with coronary heart disease

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed project proposes brain positron emission tomography (PET) with [11C]ER176, a novel radiotracer for translocator protein (TSPO), a biomarker of glial activation, [11C]WAY-100635, a selective, high-affinity agonist for serotonin 1A receptors, and near infrared spectroscopy (NIRS) to measure mitochondrial function in brain of unmedicated major depression compared with healthy volunteers. This cross-sectional study looks simultaneously at relationships between neuroinflammation, serotonin and mitochondrial function, with respect to presence of illness and severity of major depression. Results are relevant to the mission of the NIH as they have potential to unify major theories of depression pathophysiology, and findings may guide new treatment approaches that can be individualized.

PI_NAMEs: MANN, JOSEPH JOHN (contact);SUBLETTE, M ELIZABETH

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Acute;Affinity;Anterior;Autoreceptors;behavioral phenotyping;Binding;Binding Proteins;Bioenergetics;Biological Markers;Blood;Brain;Cephalic;chemokine;Chronic;Cluster Analysis;Cross-Sectional Studies;cytochrome c oxidase;cytokine;Data;Data Set;Depressed mood;depressed patient;depression model;depressive symptoms;Development;Disease remission;DSM-V;Equilibrium;Exhibits;Familial disease;Free Radicals;Functional disorder;Future;Generations;glial activation;Hamilton Rating Scale for Depression;Health;healthy volunteer;Impaired cognition;in vivo;indexing;individualized medicine;Inflammation;Inflammatory;innovation;Kynurenic Acid;Kynurenine;Lethargies;Link;Major Depressive Disorder;Measures;Mental Depression;Meta-Analysis;Methodology;Midbrain structure;Mission;Mitochondria;mitochondrial dysfunction;Modality;Modeling;Monitor;Motivation;Mus;Near-Infrared Spectroscopy;neuroinflammation;Neurons;novel;novel therapeutic intervention;Oxidative Stress;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient subsets;Patients;Peripheral;peripheral blood;personalized medicine;Pharmaceutical Preparations;Phenotype;Population;Positron-Emission Tomography;Prefrontal Cortex;Proteins;Quinolinic Acid;radiotracer;Relapse;Research;response;Sampling;serotonergic regulation;Serotonin;Serotonin Agonists;Serotonin Receptor 5-HT1A;Severities;Subgroup;theories;Tracer;trait;Translational Research;transmission process;Tryptophan;Tryptophan 2,3 Dioxygenase;United States National Institutes of Health;Volunteer Group;Work

PROJECT_TITLE: Inflammatory, mitochondrial and serotonergic interrelationships in the pathogenesis of major depression

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: This project will provide important information on the function of pial collaterals, small anastomotic arterioles in the brain that maintain perfusion to the penumbra and provide a level of salvageable tissue during large vessel occlusion (LVO). We will investigate clinically relevant strategies to enhance collateral perfusion during LVO to sustain the penumbra and improve long-term outcome from LVO. These treatments are particularly relevant for patients with co-morbidities and poor collateral flow in which current endovascular therapy or thrombolysis is delayed or inaccessible.

PI_NAMEs: CIPOLLA, MARILYN J (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;Anastomosis - action;Angiotensin II;Angiotensin-Converting Enzyme Inhibitors;arteriole;Behavioral;Blood flow;Blood Pressure;blood pressure elevation;blood pressure reduction;Brain;Cell Death;Cerebrum;Chronic;Clinical;clinically relevant;Collateral Circulation;comorbidity;constriction;Data;Distal;effective therapy;efficacy evaluation;endothelial dysfunction;Endothelium;Evolution;experimental study;Female;Functional disorder;functional status;Goals;Hydralazine;Hypertension;hypertensive;Image;Impairment;Implanted Electrodes;improved;improved outcome;In Vitro;in vivo;Inbred SHR Rats;Infarction;inhibitor;Ion Channel;Ischemia;Ischemic Stroke;Knowledge;Legal patent;Leptomeninges;male;Measures;Mediating;Middle Cerebral Artery Occlusion;Neurological outcome;Neuroprotective Agents;Nitric Oxide Synthase;normotensive;NOS3 gene;Outcome;outcome prediction;Pathway interactions;Patients;Perfusion;Plasminogen;Plasminogen Activator Inhibitor 1;pressure;prevent;Publishing;Rattus;receptor;Receptor, Angiotensin, Type 1;Reperfusion Therapy;response;Role;Serine Protease;sex;shear stress;Stroke;stroke outcome;stroke patient;stroke therapy;Telemetry;Testing;Therapeutic;therapeutic target;thrombolysis;Time;Tissues;Vanilloid;Vascular blood supply;Vascular Diseases;vasoconstriction;Vasodilation;wireless;Wistar Rats

PROJECT_TITLE: Targeting Pial Collaterals for Acute Stroke Treatment

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Neurodegenerative;Neurosciences;Nutrition;Physical Activity;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: NARRATIVE We propose an early stage pilot randomized controlled trial of a non-pharmacological intervention that was co- designed with non-Hispanic black (NHB) safety-net primary care patients and their providers. The intervention is delivered by safety-net providers and involves hypertension self-management education, Mediterranean- Dash Intervention for Neurodegenerative Delay (MIND) diet, and aerobic training. We will evaluate intervention feasibility and processes and investigate intervention effects on cognition in NHB adults with hypertension.

PI_NAMEs: CLARK, DANIEL O (contact)

PROJECT_TERMS: Address;Adult;Adverse event;Aerobic Exercise;Aftercare;Age;Age Years;age-related disease;Alzheimer's disease related dementia;attentional control;behavior change;Behavior Therapy;Biological Markers;black patient;Black race;Blood;Blood Pressure;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care seeking;Caring;Cognition;Cognitive;cooking;Dementia;dementia risk;design;Diet;diet and fitness;Disparity;Drops;Education;Educational Intervention;Educational Status;Federally Qualified Health Center;fitness;follow-up;Food;Foundations;Future;Genetic;Glycosylated hemoglobin A;health disparity;Health Personnel;high risk;Home;Hypertension;improved;Intervention;intervention cost;intervention effect;intervention participants;intervention refinement;lifestyle intervention;low socioeconomic status;Measures;Mediator;Medical;middle age;Minority;Nerve Degeneration;Nonpharmacologic Therapy;Not Hispanic or Latino;novel;nutrition;Outcome Assessment;Participant;patient oriented;Patients;pilot trial;Plasma;preference;prevent;Prevention;Prevention trial;Primary Care;primary care patient;primary care provider;Process;Provider;Public Health;Race;racial disparity;Randomized;Randomized, Controlled Trials;Recommendation;Research;Risk Factors;safety net;satisfaction;Scientist;Self Efficacy;Self Management;Site;Social support;socioeconomic disparity;Socioeconomic Status;Source;System;Testing;therapy design;therapy development;Training;treatment as usual;treatment effect;Trust;Unhealthy Diet;United States National Institutes of Health;videoconference;Work

PROJECT_TITLE: MIND Foods and Aerobic Training in Black Adults with HTN: An ADRD Prevention Pilot RCT (MAT)

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]