NIH_SPENDING_CATS: Cancer

PI_NAMEs: ALDRICH, LESLIE  (contact)

PROJECT_TERMS: Affect;Autophagocytosis;Binding;Biochemistry;Biological;Biological Assay;Biological Process;Biology;Cancer Biology;cancer therapy;Catabolic Process;Cells;Cellular biology;Chemicals;Complex;Development;Disease;disease phenotype;drug discovery;Endosomes;Energy Transfer;Eukaryota;Evaluation;Fluorescence Polarization;Goals;Health;healthy aging;high throughput screening;Homeostasis;Human;human disease;improved;in vivo;inhibition of autophagy;inhibitor;Interdisciplinary Study;interest;Laboratories;Lamin Type A;Lead;Lipids;Lysosomes;Malignant Neoplasms;Medical;Neurodegenerative Disorders;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Organic Chemistry;Pathway interactions;Pharmaceutical Chemistry;Phenotype;Phosphotransferases;Positioning Attribute;protein protein interaction;Proteins;Recycling;research clinical testing;Role;screening;small molecule;small molecule inhibitor;targeted treatment;Therapeutic;therapeutic development;therapeutic target;trafficking

PROJECT_TITLE: Development of small-molecule autophagy modulators


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: DZUTSEV, AMIRAN  (contact)

PROJECT_TERMS: Affect;Animal Model;anti-cancer research;Bacteria;cancer immunotherapy;cancer therapy;CAR T cell therapy;Clinical Trials;commensal microbes;Complex;detection method;Development;Distant;Ecosystem;Elements;fungus;host-associated microbial communities;host-microbe interactions;Human;human subject;Immune checkpoint inhibitor;Immune response;Immunotherapy;improved;Investigation;Malignant Neoplasms;Manipulative Therapies;Methodology;Methods;Microbe;microbial;microbial products;microbiome;microbiota;microorganism;Mucous Membrane;Multiomic Data;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;novel;Organ;Outcome;Patients;pre-clinical;Primary Neoplasm;Property;Research;Risk;Role;Sensitivity and Specificity;Site;Skin;Surface;T cell therapy;T-Lymphocyte;Tissues;tool;tumor;tumor progression;Virus;Work

PROJECT_TITLE: Investigation of role of microbiota in development, progression and therapy of cancers


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Prostate Cancer;Urologic Diseases

PI_NAMEs: HARMON, STEPHANIE  (contact)

PROJECT_TERMS: advanced prostate cancer;Appearance;Appointment;Architecture;artificial intelligence algorithm;autoencoder;Biological;Biological Markers;Biopsy;cancer cell;Clinical;clinical implementation;Clinical Management;Clinical Protocols;Clinical Trials;cohort;Collaborations;Collection;Complex;cost effective;Data;Development;digital;digital pathology;Disease;Equipment;genomic predictors;Genomics;Heterogeneity;Image;image processing;imaging biomarker;Individual;Institution;Literature;Localized Disease;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Medical;Metastatic Prostate Cancer;Methods;model development;Modeling;Molecular;molecular imaging;Morphology;mortality;Multi-Institutional Clinical Trial;Multimodal Imaging;multimodality;National Cancer Institute;NCI Center for Cancer Research;neoplastic cell;novel;Nuclear;Operative Surgical Procedures;Outcome;outcome prediction;Pathology;pathology imaging;Patient-Focused Outcomes;Patients;Pattern;Postbaccalaureate;Postdoctoral Fellow;predicting response;predictive modeling;predictive tools;Process;prognostic;Radical Prostatectomy;radiological imaging;Reagent;recruit;Research;Research Personnel;research study;response;Sampling;Scanning;Space Perception;Specimen;standard of care;Systemic Therapy;Techniques;Technology;tenure track;therapeutic development;therapy resistant;tool;Training;Translating;Translations;Validation;Work

PROJECT_TITLE: Development and Validation of Artificial Intelligence Algorithms in Digital Pathology


NIH_SPENDING_CATS: Bioengineering;Cancer;Emerging Infectious Diseases;Infectious Diseases;Natural Products

PI_NAMEs: MONTEIRO, DIANA  (contact)

PROJECT_TERMS: Academia;Adopted;Affect;beamline;Biology;CCR;Chemicals;Chimeric Proteins;Collaborations;Communication;Crystallization;Crystallography;data analysis pipeline;data handling;Death Rate;Development;Drug Design;drug development;drug discovery;Emerging Communicable Diseases;experimental study;Funding;Hand;Harvest;Immunocompromised Host;Industrialization;Infrastructure;instrumentation;Laboratories;large datasets;Liquid substance;Malignant Neoplasms;Metabolic Pathway;Natural Products;Oncogenic;Proteins;Robot;Roentgen Rays;Sampling;Sarcoma;Science;screening;Source;Structure;Synchrotrons;Technology

PROJECT_TITLE: High throughput crystallographic compound screening


PI_NAMEs: NIETHAMER, TERREN  (contact)

PROJECT_TERMS: activating transcription factor 3;Acute;Adult;adult stem cell;Alveolar;Appointment;Atlases;Blood capillaries;Blood Vessels;Cancer Biology;Capillary Endothelial Cell;cell behavior;Cell Line;Cell Proliferation;cell type;Cells;Chronic lung disease;Communication;Complex;Confocal Microscopy;Development;Developmental Biology;Distal;Embryo;Endothelial Cells;Endothelium;Epithelium;Equipment;functional restoration;Future;Gases;Heterogeneity;Homeostasis;Impairment;Individual;Infection;Injury;Interferons;Laboratories;Lung;lung development;lung regeneration;lung repair;Malignant neoplasm of lung;Maps;Mus;National Cancer Institute;Natural regeneration;NCI Center for Cancer Research;Population;Postbaccalaureate;Postdoctoral Fellow;postnatal;postnatal development;Process;Pulmonary alveolar structure;Reagent;recruit;Regenerative research;Research;Research Personnel;research study;Resources;response to injury;Role;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Structure;Structure of parenchyma of lung;targeted treatment;Technology;tenure track;Tissues;Training;transcription factor;Vascular regeneration;Viral;Virus Diseases;Work

PROJECT_TITLE: Endothelial plasticity and signaling in development and regeneration of the lung


PI_NAMEs: TSCHERNIA, NICHOLAS  (contact)

PROJECT_TERMS: bench to bedside;Cell Therapy;clinical center;clinically actionable;cytokine release syndrome;Dedications;Development;digital health;Early identification;Educational workshop;Extramural Activities;Fostering;Futility;Goals;Immune;industry partner;investigator-initiated trial;Laboratories;laboratory equipment;Malignant Neoplasms;Monitor;NCI Center for Cancer Research;novel;Outcome;Protocols documentation;Secondary to;Solid Neoplasm;Temperature;Testing;Toxic effect;United States National Institutes of Health;wearable device;Work;Writing

PROJECT_TITLE: Cellular Therapy Discovery for Solid Tumors


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Prostate Cancer;Urologic Diseases

PI_NAMEs: CHOYKE, PETER L (contact)

PROJECT_TERMS: Age;Area;artificial intelligence model;cancer therapy;Classification;clinical decision-making;Data;Diagnosis;Diagnostic;Disease;Goals;Human;Image;improved;Lesion;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Outcome;Patients;Positron-Emission Tomography;prognostic tool;Prostate;PSA level;radiologist;Radiopharmaceuticals;Research;Research Personnel;Scanning;Screening for Prostate Cancer;tumor;Work

PROJECT_TITLE: Radiopharmaceutical Imaging and Therapy of Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Machine Learning and Artificial Intelligence;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: NGUYEN, JOE  (contact)

PROJECT_TERMS: Affect;Algorithms;Area;Biopsy;cancer cell;carcinogenesis;cell behavior;Cell Line;Cells;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR/Cas technology;Data;Data Set;Death Rate;deep learning;deep learning model;Development;diagnostic strategy;diagnostic tool;Disease Progression;Early Diagnosis;Engineering;Environment;Future;gene network;Generations;Genes;Genetic Engineering;Goals;Head and Neck Cancer;high risk;Human;improved;individual patient;innovation;insight;Intervention;Investigation;Knock-out;Mediating;metabolomics;Methodology;mimetics;Modeling;Molecular;mouse model;mouth squamous cell carcinoma;multidisciplinary;Multiomic Data;multiple omics;Mus;new therapeutic target;novel;oral lesion;Pathogenesis;Patient-Focused Outcomes;Patients;Pattern;personalized diagnostics;personalized strategies;Phylogenetic Analysis;Play;potential biomarker;premalignant;programs;Proteomics;Regulatory Pathway;Research;Risk Assessment;Role;Sensitivity and Specificity;Signal Transduction;single-cell RNA sequencing;Smoker;Spatial Distribution;targeted treatment;Therapeutic Intervention;therapeutic target;Tissues;Tobacco;tongue root;Training;transcriptomics;treatment strategy;tumor;Tumor Burden;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Unraveling the Molecular Underpinnings of Premalignant Oral Lesion Transformation into Head and Neck Cancer


NIH_SPENDING_CATS: Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

PI_NAMEs: COOK, LEAH  (contact)

PROJECT_TERMS: Appointment;bone;Bone neoplasms;Disease;Environment;Equipment;ethnic diversity;Goals;Immune;innovation;Laboratories;Malignant Neoplasms;Metastatic Neoplasm to the Bone;Metastatic Prostate Cancer;Modeling;National Cancer Institute;NCI Center for Cancer Research;Neoplasm Metastasis;neutrophil;Patients;Postbaccalaureate;Postdoctoral Fellow;Process;programs;Reagent;recruit;Research;Research Personnel;research study;Role;Technology;Training

PROJECT_TITLE: Investigating the role of neutrophils in bone metastasis


NIH_SPENDING_CATS: Biotechnology;Cancer;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: KRUG, LAURIE T (contact)

PROJECT_TERMS: Address;American;Antibodies;Antigens;B-Lymphocytes;Biological Assay;cell type;Cells;Clinical;Collaborations;Data;design;Disease;Engineering;Funding;gammaherpesvirus;Genome;Glycoproteins;Herpesviridae;Herpesviridae Infections;Heterogeneity;Human;Human Herpesvirus 4;Human Herpesvirus 8;human model;immune activation;Immune Evasion;Immune response;Immunocompetent;immunogenicity;Immunosuppression;in vivo;in vivo Model;Incidence;Infectious Mononucleosis;Institution;Laboratories;Link;Lytic;Malignant Neoplasms;Modeling;Multiple Sclerosis;Mus;novel;pathogen;Pathogenesis;Patients;Pattern;prevent;programs;Proteins;Protocols documentation;Recombinants;response;Role;Serum;Standardization;Structure;System;T-Lymphocyte;Testing;Tissues;United States;Vaccinated;Vaccination;vaccination strategy;vaccine efficacy;vaccine formulation;vaccine platform;Vaccines;Validation;Viral Antigens;Virus

PROJECT_TITLE: Strategic Herpesvirus Immune Evasion and Latency Defense


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Pediatric;Pediatric Cancer;Rare Diseases;Skin Cancer

PI_NAMEs: YOHE, MARIELLE  (contact)

PROJECT_TERMS: Adult;checkpoint inhibition;Child;Childhood;Childhood Melanoma;Clinical;cohort;Evaluation;Family;Funding;Germ Lines;Guidelines;humanized mouse;immune checkpoint;Immunocompetent;improved;Inherited;inhibitor;MAP Kinase Gene;Melanoma;Modeling;molecular marker;mouse model;Mutation;novel;Outcome;Pathway interactions;preclinical study;Prospective Studies;Research;Resistance;resistance mechanism;Risk;Sampling;Susceptibility Gene;therapeutic target;transcriptome sequencing;transcriptomics;treatment guidelines;treatment response;tumor;variant of unknown significance;whole genome

PROJECT_TITLE: Improving Pediatric Melanoma Outcomes in a Longitudinally Evaluated Cohort


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Immunotherapy;Orphan Drug;Precision Medicine;Rare Diseases;Skin Cancer;Women's Health Research

PI_NAMEs: HANNENHALLI, SRIDHAR  (contact)

PROJECT_TERMS: Address;Adrenocortical Carcinoma;Affect;African;Aftercare;anti-cancer research;Bacteria;Benchmarking;Binding;Biological Process;Brain Neoplasms;cancer cell;Cancer Etiology;Cancer Patient;cancer subtypes;cancer type;Cell Fraction;Cell Line;cell type;Cells;Cessation of life;chemotherapy;Clinical;Clinical Trials;Code;Collaborations;CRISPR/Cas technology;Data;data integration;Data Set;differential expression;Disease;Disparate;Disseminated Malignant Neoplasm;DNA Sequence Alteration;Drug resistance;drug sensitivity;Drug Targeting;Endothelium;Epigenetic Process;Etiology;Exhibits;extracellular vesicles;Future;Gene Expression;Genes;Genetic Polymorphism;genetic signature;Genetic Transcription;Heterogeneity;Human;immune checkpoint blockade;Immune response;Immunotherapy;improved;Incidence;Knock-out;Liver;Lung;Lymphoid;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Melanoma;men;Metastatic malignant neoplasm to brain;Metastatic Melanoma;metastatic process;Modeling;mouse model;Mutation;Myelogenous;Neoplasm Metastasis;Network-based;non-genetic;novel;Patients;Pharmaceutical Preparations;Pharmacotherapy;polygenic risk score;Population;Predictive Factor;prognostic;programs;Property;Publishing;Resistance;responders and non-responders;response;Role;Shapes;single-cell RNA sequencing;Stimulus;Therapeutic;therapy resistant;Thinness;Tissues;tool;transcription factor;transcriptomics;Treatment Failure;treatment response;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor-immune system interactions;tumorigenesis;tumorigenic;Untranslated RNA;Work;Writing;Yeasts

PROJECT_TITLE: Transcriptional heterogeneity and regulatory mechanisms in tumor microenvironment


PI_NAMEs: ZHAO, CHEN  (contact)

PROJECT_TERMS: Affect;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Dendritic Cells;imaging system;Immune;Immunotherapy;Knowledge;Label;lymph nodes;Mediating;Memory;Methods;Monitor;Non-Small-Cell Lung Carcinoma;Pathway interactions;Play;recruit;Reporter;Role;System;T-Lymphocyte;therapeutic target;Time;tumor;Tumor Immunity;tumor microenvironment;two-photon

PROJECT_TITLE: Elucidate how dendritic cells affect T cells' function in the TME of non-small cell lung cancer


PROJECT_TERMS: Address;Alveolar Macrophages;CD8-Positive T-Lymphocytes;Cell Physiology;Crossbreeding;Enterobacteria phage P1 Cre recombinase;Genetic;innovation;ITGAX gene;Lung;Macrophage;Mediating;Modeling;Modification;mouse model;Mouse Strains;Mus;new therapeutic target;Non-Small-Cell Lung Carcinoma;Pathway interactions;Population;Role;System;T-Lymphocyte;Tissues;treatment strategy;tumor;tumor microenvironment

PROJECT_TITLE: Study the interactions between alveolar macrophages and T cells in non-small cell lung cancer


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Aconitic Acid;Active Sites;Binding;cancer cell;cancer therapy;Carboxy-Lyases;Cell Proliferation;Cells;chemotherapy;Crystallization;Crystallography;design;Environment;Enzymes;Goals;high throughput screening;Immune Evasion;Immune system;in silico;inhibitor;Ligands;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;novel;novel therapeutics;Nutritional Requirements;Oncogenic;Pharmaceutical Chemistry;Play;protein expression;Proteins;Protocols documentation;Regulation;Resolution;screening;small molecule;Structure;Structure-Activity Relationship;Testing;Tissues;trait;tumor growth;Work

PROJECT_TITLE: hIRG1 medicinal chemistry effort


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases;Women's Health Research

PROJECT_TERMS: Biological Assay;Cancer Patient;Cancer Prognosis;Cells;Clinical Trials;Collaborations;Communicable Diseases;Complex;Crystallization;Data;design;DNA biosynthesis;DNA Repair;Drug Design;drug discovery;Drug Targeting;Environment;in vivo;Inhibition of Cell Proliferation;inhibitor;interest;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Modeling;Monitor;novel;Oncogenic;Organism;overexpression;Penetration;Play;Prognosis;Proliferating Cell Nuclear Antigen;Proteins;Role;scaffold;screening;structural biology;Structure;Techniques;Testing;therapeutic target;Trypanosoma brucei brucei;Virginia

PROJECT_TITLE: PCNA as an oncogenic drug target


PROJECT_TERMS: Basic Science;biophysical analysis;cancer type;Cancerous;CCR;Cells;Cessation of life;Chimeric Proteins;Clinical;Development;Disease;FOXO1A gene;high throughput screening;in silico;interest;Mediating;Modeling;new therapeutic target;novel;novel therapeutics;Oncogenic;Organic Chemistry;Pathway interactions;PAX3 gene;Peptides;protein degradation;protein phosphatase inhibitor-2;protein protein interaction;Proteins;Proteomics;Structure;Synthesis Chemistry;tool;Ubiquitin;Ubiquitination;Validation;working group

PROJECT_TITLE: Structural studies of oncogenic fusion proteins and development of novel PROTACS


PROJECT_TERMS: Affect;Architecture;Brain;Cell Physiology;Collaborations;design;Drug Design;in silico;inhibitor;Modeling;Molecular;novel;novel therapeutics;prolyl oligopeptidase;Protein Secretion;Resolution;Serine Protease;Signal Transduction;Signaling Protein;Structure;Structure-Activity Relationship

PROJECT_TITLE: Structure-activity relationships in PreP inhibitor design


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: SHAH, NIRALI  (contact)

PROJECT_TERMS: Acute leukemia;Address;Adult;Affect;American;anakinra;antagonist;Antibodies;Antigens;Award;B lymphoid malignancy;B-Cell Acute Lymphoblastic Leukemia;B-Cell Leukemia;B-Cell Lymphomas;Back;bench to bedside;Biological;Biology;Blood Coagulation Disorders;Blood Component Removal;CAR T cell therapy;CD22 gene;CD28 gene;CD3 Antigens;CD8B1 gene;Cell Therapy;Cells;cellular engineering;Child;Childhood;chimeric antigen receptor T cells;Clinical;clinical center;clinical investigation;Clinical Trials;clinically relevant;Collaborations;combinatorial;Communicable Diseases;Consensus;Cryopreservation;cytokine;cytokine release syndrome;cytopenia;Dedications;Development;Disease remission;Dose;early phase clinical trial;Effector Cell;Evaluation;experience;Ferritin;Foundations;Functional disorder;Future;Goals;Guidelines;Hematologic Neoplasms;Hematology;Hemophagocytic Lymphohistiocytoses;Hepatic;high dimensionality;high risk;Hydrocortisone;IL18 gene;Immune;immune effector cell-associated neurotoxicity syndrome;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;Incidence;Inflammation;Inflammatory;Inflammatory Response;Infrastructure;Infusion procedures;insight;Interferon Type II;Interleukin-1 Receptors;interpatient variability;Investigation;Knowledge;Late Effects;Learning;leukemia/lymphoma;Life;Lymphopenia;Macrophage activation syndrome;manufacture;Mediating;Minor;Mission;Modeling;Modification;Multicenter Trials;multidisciplinary;Multiple Myeloma;Myeloid Leukemia;Myeloproliferative disease;National Comprehensive Cancer Network;Natural Killer Cells;Non-Malignant;novel;novel strategies;novel therapeutics;Oncology;Outcome;Package Insert;Patient-Focused Outcomes;Patients;pre-clinical;predictive tools;prevent;Process;Production;Prognosis;programs;Protocols documentation;Publishing;Recovery;Refractory;Relapse;Reporting;Research;Resistance;response;Rheumatology;Risk;Risk Factors;risk mitigation;Role;Scientific Advances and Accomplishments;Severities;Societies;Syndrome;synergism;T-Lymphocyte;Testing;Therapeutic;Therapeutic Index;tocilizumab;Toxic effect;transplantation therapy;treatment strategy;United States National Institutes of Health;Vision;Work;young adult;γδ T cells

PROJECT_TITLE: Comprehensive Interrogation of Toxicity Profiles Associated with Novel CAR T-cell Constructs


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: DAVIES, ERIN  (contact)

PROJECT_TERMS: 4-Hydroxy-Tamoxifen;Adult;adult stem cell;Animals;Behavior;Catalytic RNA;cell fate specification;Cell Lineage;Cells;Chimeric Proteins;Clone Cells;CRISPR/Cas technology;Development;Event;Fluorescence Microscopy;Generations;Genetic Recombination;Germ Cells;Goals;Guide RNA;Homeostasis;imaging approach;Inherited;Label;Maintenance;marine;Mediating;Monitor;Natural regeneration;Pharmaceutical Preparations;Physiological;Platyhelminths;Population;Production;promoter;regenerative;Regulation;Reporter;RNA;Somatic Cell;stem cell fate;stem cells;System;Technology;Testing;Tissues;tool;Transgenic Organisms;Work

PROJECT_TITLE: Development of transgenic tools to assess adult stem cell potency and behavior in the regenerative flatworm Macrostomum lignano


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: SUMMERS, RONALD M. (contact)

PROJECT_TERMS: Abdominal Aortic Aneurysm;abdominal CT;accurate diagnosis;Affect;American;Area;Atherosclerosis;Body Composition;bone;Cancer Etiology;Cathartics;Cessation of life;Colon;Colonic Polyps;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer screening;Computed Tomographic Colonography;computer aided detection;Computer software;Consumption;deep learning;Densitometry;detection platform;Diabetes Mellitus;Diagnosis;Disease;Economics;follow-up;Future;Goals;Human;Image;improved;Incidence;Intestines;Kidney Calculi;Laboratories;Length;Malignant Neoplasms;Measures;Metabolic syndrome;Methods;Minerals;Modification;Optics;Osteoporosis;Pancreas;Patients;Perception;Physicians;Polyps;Preparation;radiologist;sarcopenia;screening;Sedation procedure;Sensitivity and Specificity;software development;Techniques;Testing;Time;Training;Tube;X-Ray Computed Tomography

PROJECT_TITLE: Computer Aided Detection for CT Colonography


PROJECT_TERMS: Abdomen;abdominal CT;Algorithms;Arterial Fatty Streak;Artificial Intelligence;Big Data;Body Composition;Clinical;computer aided detection;Computer Assisted;Computer-Assisted Diagnosis;Computers;convolutional neural network;Data;deep learning;Detection;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Errors;Disease;disease diagnosis;Early Diagnosis;Edema;Health;Image;image registration;improved;Kidney;large language model;Lead;Lesion;Liver;Machine Learning;Magnetic Resonance Imaging;Measurement;Medical Imaging;Methods;MRI Scans;Muscle;Network-based;Organ;Pancreas;Patients;Performance;Phase;Physicians;radiological imaging;radiologist;Reporting;Roentgen Rays;Scientific Advances and Accomplishments;skills;Spleen;Techniques;Training;training data;United States National Institutes of Health;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Computer Aided Detection for Radiologic Images


PI_NAMEs: MANNES, ANDREW  (contact)

PROJECT_TERMS: 7q11.23;Absence of pain sensation;Acute Pain;Address;Advanced Malignant Neoplasm;Affect;Afferent Neurons;Agonist;Analgesics;Anesthesia procedures;Animals;Arthralgia;Autopsy;Axon;Basic Science;Behavior;Binding;Biological;Brain;Calcium;Calcium ion;cancer pain;Case Study;Cells;Central Nervous System;Cerebrospinal Fluid;chronic pain;chronic painful condition;Clinical;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Collaborations;Copy Number Polymorphism;Coupled;cytotoxicity;density;Development;direct application;Dorsal;Dose;effective intervention;Exhibits;experimental study;FDA approved;Gene Expression;Genes;Genetic;Genetic Variation;genomic locus;Goals;Human;human tissue;Immune;Immunofluorescence Immunologic;In Situ Hybridization;Individual;Infiltration;Inflammation;information processing;Injections;injured;Institutional Review Boards;Intervention;Intractable Pain;Investigation;Ion Channel;Joints;Knowledge;Lesion;Lidocaine;Mechanics;Mediating;Methodology;Modeling;Molecular;Molecular Biology;Morton's Neuroma;Motor;National Center for Complementary and Integrative Health;National Institute on Deafness and Other Communication Disorders;Nerve;Nerve Endings;Nerve Fibers;nerve injury;Neuroma;Neuronal Plasticity;Neurons;neurosurgery;Nociception;Nociceptors;novel therapeutic intervention;oral mucositis;Organ Donor;osteoarthritis pain;overexpression;Pain;Pain management;pain processing;Pain Research;pain sensation;pain sensitivity;pain signal;painful neuropathy;Pathway interactions;Patients;perineural;Peripheral;Peripheral Nerves;Peripheral Nervous System;Persistent pain;Phantom Limb Pain;pharmacologic;Pharmacotherapy;phase 1 study;Phase I Clinical Trials;Physiological Processes;Pilot Projects;pre-clinical;Pre-Clinical Model;preclinical study;preservation;pressure;prevent;Process;programs;Property;Proprioception;Proteins;Protocols documentation;Publications;Publishing;Regional Cancer;Research;Resiniferatoxin;Route;Sensory Ganglia;Serious Adverse Event;Signal Transduction;single nucleus RNA-sequencing;Site;Skin;small molecule;sodium ion;species difference;Spinal Cord;Spinal Ganglia;Stains;subcutaneous;Surgical incisions;Synapses;Techniques;Therapeutic;Therapeutic Agents;Time;tissue injury;Tissues;Touch sensation;transcriptome sequencing;Transducers;translational potential;Translational Research;translational study;transmission process;Trigeminal Neuralgia;TRPV1 gene;United States National Institutes of Health;wound healing;Writing

PROJECT_TITLE: Integrative And Molecular Studies Of Pain And Pain Control


PROJECT_TERMS: Acute Pain;Adaptive Immune System;Address;Affect;Afferent Neurons;Analgesics;Animal Model;Animals;Antibodies;antibody detection;antigen test;Antigens;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune Process;Autoimmune Responses;Autoimmunity;Autopsy;Bacterial Infections;Biological;Biological Assay;Biological Factors;Biological Markers;Body part;C Fiber;Cell membrane;Cell Surface Proteins;Cells;Central Nervous System;Cerebrospinal Fluid;Cessation of life;chemotherapeutic agent;Chemotherapy-induced peripheral neuropathy;Chickenpox;Chronic;chronic neuropathic pain;chronic pain;chronic pain patient;chronic painful condition;Clinical;cohort;Communicable Diseases;Communication;Complex;cytokine;Data;Data Set;Diabetes Mellitus;diabetic;Diagnostic;diagnostic biomarker;diagnostic tool;Diameter;Disease;disorder control;drug development;Dysesthesias;Enzymes;Evaluation;Evolution;Extracellular Domain;Fiber;Ganglia;Generations;Genome;Goals;Headache;Herpes zoster disease;Herpesvirus 1;Herpesvirus Type 3;Human;human disease;Immune;Immune response;Immunology;Immunoprecipitation;Infection;Inflammation;Injury;Innate Immune System;insight;Intervention;Investigation;Ion Channel;Knowledge;latency associated transcript;Ligands;Liquid substance;Luciferases;luminescence;Maintenance;Mammalian Cell;Measures;Membrane;Membrane Proteins;Metabolic Diseases;Methodology;Migraine;Modeling;Molecular;Nature;Nerve;Nerve Endings;Nerve Fibers;nerve injury;Nervous System;Nervous System Disorder;neural;Neurobiology;Neuroimmunomodulation;Neurons;Neuropathy;Nociception;Nociceptors;Operative Surgical Procedures;Pain;pain chronification;Pain Disorder;painful neuropathy;Paraneoplastic Polyneuropathy;pathogenic autoantibodies;Pathogenicity;Pathologic;Patients;Peptides;Peripheral Nerves;Peripheral Nervous System Diseases;Persons;Pharmaceutical Preparations;Phase;Plasma;Postherpetic neuralgia;Predictive Value;Process;Production;Protein Fragment;Proteins;Publishing;receptor;Recombinant Proteins;Recording of previous events;Reporting;Research;Role;Saliva;Sampling;Schwann Cells;Serum;Signal Pathway;Signaling Protein;Specificity;Spinal Cord;Spinal cord damage;Structure of trigeminal ganglion;System;Technology;Testing;Thinking;Time;tissue injury;Tracer;Transcript;transcriptome;transcriptome sequencing;translational research program;Transmembrane Domain;transmission process;Trauma;Traumatic injury;Viral;virology;Virus;Virus Diseases;Whole Blood

PROJECT_TITLE: Mechanisms of Pain and Immune Processes


PROJECT_TERMS: Absence of pain sensation;Acute Pain;Address;Analgesics;analog;Anesthetics;Animal Model;Autopsy;Axon;Basic Science;behavior measurement;Biochemical;Biological;Brain;Cancer Control;cancer pain;Canis familiaris;Capsaicin;Capsicum;CARTPT gene;Cells;chronic pain;chronic painful condition;clinical pain;clinical practice;Clinical Research;Clinical Trials;clinically relevant;Code;combinatorial;Communication;Complex;Custom;Data;Data Analyses;density;design;Development;Disease;dorsal horn;effective intervention;endogenous opioids;Environment;Enzymes;Esthesia;Experimental Models;Exposure to;Fluorescent in Situ Hybridization;ganglion cell;Gene Expression;gene induction;Generations;Genes;Goals;Hour;Human;human study;human tissue;Immune;In Situ;In Situ Hybridization;in vivo;Individual;Inflammation;Inflammatory;insight;Intervention;Investigation;Ion Channel;Knowledge;Leucocytic infiltrate;Ligands;lipidomics;Lipids;Macrophage;Measures;Mediating;Mediator;Messenger RNA;Methods;Molecular;Molecular Biology;Molecular Neurobiology;Molecular Profiling;mu opioid receptors;Muscle satellite cell;Nerve;nerve damage;nerve injury;neural;neural circuit;Neuroglia;neuronal cell body;Neurons;Neuropathy;Neuropeptides;neurotransmission;Nociception;Nociceptors;non-opioid analgesic;novel strategies;Opioid;Opioid agonist;opioid epidemic;Organ;Organ Donor;Pain;Pain management;pain sensation;painful neuropathy;Pathologic;Pathway interactions;Patient Recruitments;Patients;Peptides;perineural;Peripheral;Phenotype;Photobleaching;Physiology;Population;Process;prodynorphin;proenkephalin;programs;Proteins;Protocols documentation;Publications;Rattus;receptor;recruit;Regulation;Reporting;Research;Resiniferatoxin;Resolution;Rodent;Role;Route;Sampling;Sensory Nerve Endings;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Site;Skin;software infrastructure;Spinal;Spinal Cord;Spinal Ganglia;Spine pain;Supporting Cell;Surgeon;Surgical incisions;System;Techniques;therapeutic development;Therapeutic Intervention;Therapeutic Uses;Time;Tissues;Transcript;transcriptome;transcriptome sequencing;transcriptomics;transmission process;TRPV1 gene;Work;wound;wound closure;wound healing

PROJECT_TITLE: The Pain Neural Transcriptome


PI_NAMEs: MERKE, DEBORAH  (contact)

PROJECT_TERMS: 21-hydroxylase deficiency;adeno-associated viral vector;Adenovirus Vector;Adrenal Glands;Adult;Age;Animals;Biodistribution;Cardiovascular Diseases;Cessation of life;clinical development;Clinical Trials;Congenital adrenal hyperplasia;CYP21A2 gene;Death Rate;Dependovirus;design;Diagnosis;Dose;effective therapy;efficacy evaluation;enzyme activity;expression vector;first-in-human;gene therapy;Human;human study;Incidence;Injections;intravenous injection;Lead;Life;life span;Mendelian disorder;Metabolic Diseases;Monitor;Mus;nonhuman primate;open label;Participant;Patients;Phase;Phenotype;pre-clinical;programs;Quality of life;Recombinants;Research Design;Risk;Safety;safety assessment;Serotyping;sex;Shock;standard of care;Steroid biosynthesis;vector;vector genome;Weight Gain

PROJECT_TITLE: Gene Therapy for Congenital Adrenal Hyperplasia through Administration of an Adeno-Associated Virus (AAV) Serotype 5-Based Recombinant Vector Encoding the Human CYP21A2


PROJECT_TERMS: 21-hydroxylase deficiency;Adrenal Cortex Diseases;Adrenal Glands;Adult;Aldosterone;androgen excess;Androgens;Biochemical;Biological Markers;Circadian Rhythms;Clinical;clinical center;conventional therapy;design;Dexamethasone;disorder control;Dose;Failure;Formulation;Glucocorticoids;Goals;Growth;Hormonal;Hormone replacement therapy;Hormones;Hour;Hydrocortisone;improved;Infertility;International;Long-Term Effects;Menstruation;Metabolic syndrome;Multicenter Studies;novel;novel therapeutic intervention;Obesity;Osteoporosis;Outcome;Patient-Focused Outcomes;Patients;Phase;phase 2 study;phase 3 study;Phase III Clinical Trials;Physiological;Prednisone;Pregnancy;primary outcome;Randomized;Randomized, Controlled Trials;Reporting;restoration;Serum;standard care;United States National Institutes of Health;Virilism

PROJECT_TITLE: Modified-release Hydrocortisone Therapy as a Treatment for CAH


PROJECT_TERMS: 10 year old;21-hydroxylase deficiency;6p21.3;Acceleration;Adrenal gland hypofunction;Adrenal Gland Neoplasms;Adrenal hormone preparation;Adult;Affect;androgen excess;Androgens;Anxiety;Attenuated;Biochemical;Bone Density;bone health;Cardiovascular Diseases;cardiovascular risk factor;carrier status;Child;Child Development;Childhood;Chimera organism;chimeric gene;Chromosome 6;Chromosome Arm;Chronic;Chronic stress;Clinical;Clinical Management;clinical phenotype;Clinical Trials;Cognition;cohort;Complex;Congenital adrenal hyperplasia;Country;COVID-19 pandemic;critical period;CYP21A2 gene;Data;design;Development;Disease;disorder control;Distress;early experience;efficacy evaluation;Ehlers-Danlos Syndrome;emerging adult;Emotional;Enrollment;Epigenetic Process;Etiology;Evaluation;Exposure to;Female infertility;Future;Gene Deletion;Gene Duplication;General Population;Genes;Genetic;Genetic Counseling;Genetic study;Genotype;Glucocorticoids;Gonadal Steroid Hormones;Gonadotropin-Releasing Hormone Analog;Growth;Growth and Development function;health related quality of life;Height;High Prevalence;Hormonal;Hyperandrogenism;in utero;Individual;instrument;Knowledge;Life;life span;male;Maps;Measurement;Mediating;Memory;men;Mental Health;Metabolic;Molecular;Morbidity - disease rate;Names;National Health and Nutrition Examination Survey;Natural History;Neonatal Screening;novel;Outcome;Patient Outcomes Assessments;Patient Recruitments;Patients;Phenotype;Population;Precocious Puberty;premature;profiles in patients;promote resilience;protective factors;Pseudogenes;psychologic;Psychological Impact;Puberty;Quality of life;Rare Diseases;Reporting;research clinical testing;Research Personnel;response;Retrospective Studies;Risk;Risk Assessment;Role;screening program;sex;Sex Differences;Steroid 21-Monooxygenase;Syndrome;Tenascin;tenascin X;Testicular Neoplasms;Therapeutic Intervention;US State;Variant;Woman

PROJECT_TITLE: Natural History Study of Patients with Excess Androgen


PROJECT_TERMS: Adrenal Gland Hyperfunction;Adrenal Glands;Adult;Androgen Antagonists;Androgens;Aromatase Inhibitors;bone;Child;Child Development;clinical center;conventional therapy;Data Analyses;Dose;Estrogens;Flutamide;Goals;Gonadal Steroid Hormones;Growth;Growth and Development function;Height;Hydrocortisone;Hyperandrogenism;improved;Letrozole;novel;Patients;prevent;prospective;Randomized;Regimen;Retrospective Studies;Treatment Protocols;United States National Institutes of Health

PROJECT_TITLE: Novel treatment approaches: sex steroid blockade in children


PROJECT_TERMS: Adrenal Glands;Adrenal hormone preparation;adverse outcome;Affinity;alternative treatment;Androgens;Androstenedione;antagonist;Biological Markers;Chronic;Clinical Research;Congenital adrenal hyperplasia;Corticotropin;Corticotropin-Releasing Hormone;CRF receptor type 1;Development;Disease;disorder control;Dose;Double-Blind Method;Functional disorder;Glucocorticoids;healthy volunteer;Hypothalamic structure;Maintenance;Minor;novel therapeutics;Patients;Phase;phase 2 study;Physiological;Pituitary Gland;placebo controlled study;placebo group;Placebos;Production;Randomized;receptor;Reporting;safety study;Serum;small molecule

PROJECT_TITLE: Study of a corticotropin releasing factor-1 receptor antagonist for the treatment of congenital adrenal hyperplasia


PI_NAMEs: PATTERSON, AMY PATE  (contact)

PROJECT_TERMS: Affect;African Trypanosomiasis;age related;antagonist;APOL1 gene;Apolipoprotein A-I;Apolipoproteins;Apolipoproteins B;Atherosclerosis;Biology;Blood Vessels;Cardiovascular Diseases;CD36 gene;Cells;Cholesterol Esters;Chronic;Clinical;Collaborations;Coronary Arteriosclerosis;coronary plaque;Cytidine;Data;Defense Mechanisms;Development;DNA;endothelial dysfunction;Event;Family;fatty acid transport;Frequencies;Genome;Hepatitis B Virus;High Density Lipoproteins;high risk;Host Defense;Host Defense Mechanism;Human;Hydrolysis;Immunity;In Vitro;in vivo;Induced Mutation;Infection;Inflammation;Innate Immune Response;Innate Immune System;Integral Membrane Protein;Intervention;Investigation;Kidney;Kidney Diseases;Link;lipid metabolism;Lipids;Lipoprotein Binding;Lipoprotein Receptor;Lipoproteins;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Lung;lung injury;Lytic;Malignant - descriptor;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic syndrome;Metabolism;Molecular;Mutate;Mutation;National Heart, Lung, and Blood Institute;Natural Immunity;Nucleocapsid;Organ;Parasites;particle;pathogen;Pathologic;Pathway interactions;Pattern;Peptides;pgRNA;Phospholipids;Physiological;Play;polypeptide;Population;preference;prevent;prophylactic;Protein Family;protein function;Proteins;Publishing;receptor;Regulation;Research;Reverse Transcription;Risk;RNA Splicing;Role;SARS-CoV-2 pathogenesis;SARS-CoV-2 spike protein;Signal Transduction;Site;Sorting;SR-B proteins;Therapeutic;therapeutic target;Tissues;Transcription Process;Triglycerides;Trypanosoma;Trypanosoma brucei rhodesiense;uptake;Uridine;Variant;vascular endothelial dysfunction;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Role of Class B Scavenger Receptors in Lipid Metabolism and Inflammation


PROJECT_TERMS: 3D Print;Adult;Animal Model;burden of illness;Caring;Clinical Trials;cost;design;Devices;Emergency Situation;endotracheal;Evaluation;first-in-human;Goals;Human;human data;In Vitro;Lung;Lung Diseases;Maintenance;Mechanical Ventilators;Operative Surgical Procedures;Organ Donor;Oxygen;patient population;Patients;pre-clinical;pressure;Preventive;Respirators;respiratory;Schedule;Systemic disease;Time;Training;Translating;Tube;Ventilator;Work

PROJECT_TITLE: First in-human trial of Miniature in-line pressure cycled, emergency respirator device at the end of scheduled surgical procedure


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioids;Pain Research;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

PI_NAMEs: SU, TSUNG PING  (contact)

PROJECT_TERMS: addiction;Adrenal Glands;Affect;Agonist;Alzheimer's Disease;Amnesia;Amygdaloid structure;antagonist;behavioral study;Binding;Biochemical;Biological;Biological Process;Brain;Calcium;Cell membrane;Cells;Cellular biology;Cellular Stress;Client;Clinical;Cocaine;Cocaine Dependence;cocaine reward;cocaine self-administration;Cocaine withdrawal;cohort;craving;Data;Decision Making;Development;Disease;dopaminergic neuron;Dose;Electrophysiology (science);endocannabinoid signaling;Endoplasmic Reticulum;Fentanyl;Foundations;Future;gamma-Aminobutyric Acid;Genomics;Glutamates;Goals;Heart;human disease;Hydrogen Peroxide;Hyperalgesia;in vivo Model;Incubated;Induced Neurons;Integral Membrane Protein;knock-down;Knock-out;Knockout Mice;Laboratories;Life;Ligands;Lipid Binding;Liver;Lung;Malignant Neoplasms;Mediating;Mental Depression;Methamphetamine;migration;Molecular;Molecular Chaperones;Molecular Mechanisms of Action;monomer;Morphine;Mothers;mu opioid receptors;Mus;National Institute of Drug Abuse;Nature;Neonatal Abstinence Syndrome;neuronal excitability;Neurons;novel;novel therapeutics;Nuclear;Opioid;Organ;Organism;Oxidative Stress;Pain;Parkinsonian Disorders;Pentazocine;Peripheral;pharmacologic;Play;preclinical study;preconditioning;Pregnancy;presynaptic;Process;Property;Proteins;Publications;Publishing;pup;Rattus;Receptor Activation;RNA;RNA Binding;Role;Self Administration;Sensory;sigma receptors;sigma-1 receptor;Signal Transduction;Spleen;Stimulus;Stress;stressor;Stroke;Structure;Testing;Thapsigargin;Tissues;Tubular formation;vapor;Work

PROJECT_TITLE: Biological And Biochemical Characterization Of Sigma Receptors


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Drug Abuse (NIDA only);Neurosciences;Opioids;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: SHAHAM, YAVIN  (contact)

PROJECT_TERMS: Abstinence;adverse outcome;Agonist;Animal Model;antagonist;Behavior;Behavioral;Brain;Claustral structure;Cocaine;Corpus striatum structure;Cues;Desire for food;Drug usage;Drug user;Event;Exposure to;Extinction;Fentanyl;Food;Goals;Heroin;Home;human subject;Laboratory Animals;Methamphetamine;Modeling;Negative Reinforcements;Neurobiology;neurochemistry;Neurons;Neurotransmitters;non-drug;novel;Opioid;Oxycodone;peer;Persons;Pharmaceutical Preparations;programs;psychostimulant;Rattus;Recording of previous events;Relapse;Reporting;Research;Rewards;Role;Self Administration;Social Interaction;Stimulus;System;Testing

PROJECT_TITLE: Neurobiology Of Relapse To Opiate and Psychostimulant Drugs


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

PI_NAMEs: HOPE, BRUCE  (contact)

PROJECT_TERMS: 3-Dimensional;addiction;Address;Adult;Area;Attenuated;Back;Bathing;Behavior;Behavioral;beta-Galactosidase;Brain;Brain region;Breeding;Calcium;Cell Nucleus;Cells;Characteristics;Chemicals;Cocaine;cocaine seeking;cocaine self-administration;Collaborations;conditioned place preference;Corpus striatum structure;Cue-induced relapse;Cues;Dendritic Spines;Dissociation;Drug Addiction;drug induced behavior;drug of abuse;Electrophysiology (science);Environment;Enzymes;experimental study;Exposure to;Extinction;Fluorescence-Activated Cell Sorting;Food;FOS gene;Glutamates;Goals;Green Fluorescent Proteins;Heroin;Human;Image;Injections;Label;LacZ Genes;learned behavior;Learning;Light;Malignant Neoplasms;Mediating;Memory;Messenger RNA;Methods;Microscopy;Modeling;Molecular;Morphology;Mus;N-Methylaspartate;Neuronal Plasticity;Neurons;Neurotransmitters;novel;Nucleus Accumbens;Pharmaceutical Preparations;Phosphorylation;Play;Prefrontal Cortex;Preparation;Presynaptic Terminals;Procedures;Process;Proteins;Rattus;Relapse;Resolution;response;Rewards;Role;Self Administration;Signal Transduction;Slice;Social Interaction;Sorting;Stimulus;suicide substrates;Synapses;Synaptosomes;temporal measurement;therapeutic target;Training;transcriptome sequencing;Transgenic Organisms

PROJECT_TITLE: Characterization of neuronal ensembles activated during cue-induced reward seeking


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health;Substance Misuse

PI_NAMEs: YANG, YIHONG  (contact)

PROJECT_TERMS: Acetylcholine;addiction;Address;Adolescent;adverse childhood events;aged;Algorithms;Anterior;Architecture;Area;Autopsy;Behavioral;Bilateral;Brain;brain based;Brain Diseases;Brain region;Buffers;Cell Nucleus;Characteristics;Chronic;cingulate cortex;clinical application;cognitive control;cognitive development;cognitive function;cohort;Communities;connectome;Corpus striatum structure;Data;Development;Diagnostic;Disease;DSM-V;Effectiveness;Etiology;Exhibits;experience;falls;Female;follow-up;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;Gene Expression;human data;imaging biomarker;improved;indexing;Individual;Least-Squares Analysis;Link;Magnetic Resonance Imaging;Major Depressive Disorder;Manuscripts;Medial;mental development;Mental disorders;Meta-Analysis;Methodology;Methods;Modeling;Molecular;Molecular Analysis;Motor;neural;neurobiological mechanism;neuroimaging;neurophysiology;neuroregulation;Noise;outcome prediction;Parietal Lobe;Pathologic;Pathway interactions;personalized intervention;Persons;preadolescence;Prefrontal Cortex;prospective;Psychiatric therapeutic procedure;Psychiatry;Psychopathology;putamen;receptor;Relapse;repetitive transcranial magnetic stimulation;Reproducibility;Research Project Grants;resilience;resilience factor;Resolution;Rest;Scalp structure;Scanning;Schizophrenia;Serotonergic System;Signal Transduction;Site;Spatial Distribution;Structure;Substance Use Disorder;System;Techniques;tool;Transcranial magnetic stimulation;Treatment Efficacy;Verbal Auditory Hallucinations;Work;Youth

PROJECT_TITLE: Development of MRI Techniques for Applications in Substance Use Disorders


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Mental Health;Neurosciences;Opioids;Substance Misuse

PI_NAMEs: FERRE, SERGI  (contact)

PROJECT_TERMS: abuse liability;Acute;Address;Adrenergic Receptor;Affect;Amino Acids;Anxiety;Attention deficit hyperactivity disorder;Attentional deficit;Behavior;Behavior monitoring;Behavioral;behavioral phenotyping;behavioral study;Binding;Biochemical;Biological Assay;Brain;Cell Nucleus;Cells;Clinical Research;Cognitive;Complement;Corpus striatum structure;dimer;Disease;Dopamine;Dopamine Receptor;Dopaminergic Cell;dopaminergic neuron;DRD4 gene;Efferent Pathways;enantiomer;endophenotype;experimental study;extracellular;Fentanyl;flexibility;Fluorescence;foot;frontal lobe;gain of function;Galanin;Gene Modified;Genes;Genetic Polymorphism;Glutamates;Goals;hippocampal pyramidal neuron;Human;Impairment;Impulsivity;In Vitro;in vivo;Individual Differences;interest;Link;loss of function;Mammalian Cell;Medial;Mediating;Mediator;Methadone;Microdialysis;Minisatellite Repeats;Molecular Conformation;molecular dynamics;Monitor;Morphine;Movement;mu opioid receptors;Mus;Neurons;neuropsychiatric disorder;neurotransmission;NMDA receptor antagonist;Norepinephrine;novel;Opioid;Opioid agonist;opioid use disorder;optogenetics;Outcome;Perfusion;Personality Traits;pharmacologic;Phenotype;Play;Population;Proline;Property;Protein Isoforms;Protomer;Rattus;receptor;Reporting;response;Rewards;Risk Taking;Role;Self Administration;Shock;Short-Term Memory;Site;social;social deficits;Stimulus;Structure;Substance Use Disorder;Techniques;Transfection;Transmembrane Domain;Variant;Ventral Tegmental Area

PROJECT_TITLE: Functional and Pharmacological Significance of Receptor Heteromers in the CNS


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Natural Products;Substance Misuse

PI_NAMEs: EPSTEIN, DAVID  (contact)

PROJECT_TERMS: Automobile Driving;Behavior;Behavioral;Clinic;Cocaine use disorder;Complement;Data;Data Analyses;Drug Monitoring;Drug usage;Drug user;Ecological momentary assessment;Environment;Faculty;Goals;interest;Life;marijuana use;marijuana use disorder;meetings;member;Mental association;mental state;Methods;Mitragyna;Moods;Motivation;National Institute of Drug Abuse;Nicotine;opioid use disorder;Outcome;Outpatients;Paper;Participant;Persons;Pharmaceutical Preparations;Physiological;Plants;Population;Postdoctoral Fellow;Publications;Publishing;real time model;real time monitoring;Reporting;Research;Running;Sampling;Site;telework;Testing;Time;Tobacco

PROJECT_TITLE: Real-Time Assessment of Drug Use, Along with Mental States and Environments


NIH_SPENDING_CATS: Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: MORALES, MARISELA  (contact)

PROJECT_TERMS: Animal Model;Behavior;Clinical Research;Cocaine;cocaine seeking;cohort;combinatorial;conditioned place preference;Dopamine;dopaminergic neuron;Drug Addiction;drug of abuse;Enzymes;Fiber;Follow-Up Studies;gamma-Aminobutyric Acid;Glutamate Decarboxylase;Glutamate Transporter;Glutamates;Goals;Implant;interdisciplinary approach;Measures;mesolimbic system;Mus;Neurons;Nucleus Accumbens;optical fiber;Output;Pathway interactions;Play;Population;preference;recombinase;Regulation;Relapse;reward processing;Rewards;Role;selective expression;Serotonin;serotonin transporter;Site;SLC17A8 gene;Study models;Synapses;Transgenic Mice;Tyrosine 3-Monooxygenase;vector;Ventral Tegmental Area;Viral Vector

PROJECT_TITLE: Neuronal connectivity within the mesolimbic system


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Immunization;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Vaccine Related

PI_NAMEs: RICE, KENNER  (contact)

PROJECT_TERMS: Agonist;analog;antagonist;Antibodies;Antibody Affinity;Antibody Response;Antigens;antinociception;Appearance;Bacterial Proteins;Behavioral;Biological Assay;Brain;Buprenorphine;Candy;carfentanil;chemical synthesis;Child;China;Clinical Medicine;Clinical Research;Color;combat;Combined Vaccines;Complex;cost;Cyclic AMP;Data;design;Disease;Dose;Drug abuse;drug action;Drug Addiction;drug of abuse;Drug Targeting;Exhibits;Fentanyl;Firearms;Goals;Haptens;head-to-head comparison;Heroin;Homicide;imaging agent;Immunize;immunogenic;Immunoglobulin G;improved;In Vitro;in vivo;interest;Label;Legal patent;Licensing;Ligands;manufacture;Mediating;Methadone;Mexico;Monoclonal Antibodies;Mouse Strains;multidisciplinary;Mus;mutant;Naloxone;Naltrexone;Narcotics;new chemical entity;novel;novel therapeutics;novel vaccines;Opioid;opioid abuse;Opioid Antagonist;opioid epidemic;opioid mortality;Opioid Receptor;Opium;overdose death;Pain;Papaver;Pattern;Peripheral;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacologic Substance;phenylmorphan;pill;Population;Positron-Emission Tomography;Powder dose form;prevent;Prevention;Production;programs;Proteins;rational design;Rattus;receptor;Research;Research Personnel;response;Seizures;Series;small molecule;Stress;Suicide;synthetic opioid;System;Tablets;Technology;Tetanus Toxoid;tool;Toxic effect;Vaccine Production;Vaccines;vehicular accident;Ventilatory Depression

PROJECT_TITLE: Medicinal Chemistry of Drugs Acting on Central and Peripheral Opioid Receptors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Drug Abuse (NIDA only);Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Substance Misuse

PROJECT_TERMS: Affinity;Agonist;Autophagocytosis;Brain;C9ORF72;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Clinical;Cytosol;Data;design;Disease;Drug usage;Fluvoxamine;frontotemporal lobar dementia amyotrophic lateral sclerosis;Impairment;Importins;Ligands;Mediating;Metabolism;Molecular Chaperones;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;Neuroglia;neuronal survival;Neurons;non-opioid analgesic;Nuclear;Nuclear Pore;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Pathologic;Poison;Pore Proteins;receptor;recruit;RNA;Serotonin;sigma-1 receptor;Signaling Molecule;Stress;Therapeutic Agents;therapeutic development;transcription factor

PROJECT_TITLE: Neurobiological Basis of Neuronal Survival


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;HIV/AIDS;Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PI_NAMEs: HARVEY, BRANDON  (contact)

PROJECT_TERMS: Acute;adeno-associated viral vector;Affect;Cell Line;Cells;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Corpus striatum structure;CRISPR/Cas technology;DNA;Dose;drug of abuse;Exposure to;GAG Gene;Genetic Transcription;Genome;Goals;Health;HIV;HIV Long Terminal Repeat;In Vitro;in vivo;Investments;Long Terminal Repeats;Luciferases;Methamphetamine;Microglia;Modeling;Monitor;neuroinflammation;Neurons;neurotoxicity;novel;Pharmaceutical Preparations;pol genes;Production;promoter;Proteins;Proviruses;psychostimulant;Research;Ribonucleoproteins;RNA;Rodent;Role;Substance Addiction;tool;Transgenic Organisms;vector;Work

PROJECT_TITLE: Microglia, HIV and drugs of abuse


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Genetics;Hearing Loss;Neurosciences

PI_NAMEs: KELLEY, MATTHEW  (contact)

PROJECT_TERMS: Adult;Afferent Neurons;Alagille Syndrome;Alleles;Animals;Auditory;Bioinformatics;Candidate Disease Gene;candidate identification;Cell Survival;cell type;Cells;Cochlea;cochlear development;Collaborations;Cranial Nerves;Data;deafness;Defect;Development;Developmental Process;Ear;Embryonic Development;Epithelium;Fibroblast Growth Factor;Ganglia;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Germ Cells;Goals;Hair Cells;Hearing;hearing impairment;hearing restoration;hindbrain;Human;improved;interest;Laboratories;Labyrinth;Mammals;Mediator;member;Molecular;Mus;Mutant Strains Mice;nerve supply;Neurons;Neurosciences;novel;Organ of Corti;otoconia;Outer Hair Cells;Pathway interactions;Patients;Pattern;Phenotype;Process;Production;Reporting;Research;Research Personnel;Role;Sensory;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;spiral ganglion;Structure;Supporting Cell;Suppressor-Effector T-Lymphocytes;Syndrome;System;Testing;transcription factor;transcriptome;Transgenic Mice;Universities;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;vestibular system

PROJECT_TITLE: Hair Cell Development in the Mammalian Cochlea


NIH_SPENDING_CATS: Batten Disease;Bioengineering;Brain Disorders;Clinical Research;Congenital Structural Anomalies;Data Science;Eye Disease and Disorders of Vision;Hearing Loss;Intellectual and Developmental Disabilities (IDD);Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Prevention;Rare Diseases;Usher Syndrome

ORG_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

PI_NAMEs: HERTZANO, RONNA  (contact)

PROJECT_TERMS: Age;Algorithms;Amikacin;Aminoglycoside Antibiotics;Animal Model;Antineoplastic Agents;arterial calcification of infancy;Auditory;Auditory Evoked Potentials;Auditory system;autosome;Brain Neoplasms;Cantor;Characteristics;Cisplatin;Clinical;Clinical Research;Clinical Trials;CLN3 gene;cloud based;Code;Collaborations;Computer software;Computerized Medical Record;Congenital disorders of glycosylation;Cryptococcal Meningitis;Data;Data Analyses;Data Analytics;Data Science;data sharing;Data Storage and Retrieval;data visualization;design;Development;Disease;Early Diagnosis;Electrocochleographies;electronic data;Electronics;Environmental Risk Factor;Equilibrium;experience;Extramural Activities;Family;Funding;Gangliosidoses;Genotype;Grant;Healthcare;Hearing;hearing impairment;Hearing problem;human model;improved;Infrastructure;inhibitor therapy;interest;ketotic hyperglycinemia;Laboratories;Labyrinth;large scale data;loss of function;malformation;Manuscripts;McCune-Albright Syndrome;Measures;Medical;MEKs;Mentors;Mentorship;Methodology;methylmalonic aciduria;multidisciplinary;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;National Institute of Neurological Disorders and Stroke;National Institute on Deafness and Other Communication Disorders;Natural History;Neimann-Pick's Disease Type C;Neurofibromatosis 1;New Agents;Noise;Normal Range;Osteogenesis Imperfecta;otoacoustic emission;ototoxicity;Paper;Patients;Persons;Phenotype;Physiologic pulse;Platinum;Posture;Predisposition;Prevalence;Prevention;programs;prospective;Protocols documentation;Publishing;Radiation therapy;Reference Values;Relapse;Research;Research Design;Research Infrastructure;Research Personnel;Retrospective Studies;Risk;Risk Factors;Science;Scientist;sex;Sex Differences;Smith-Lemli-Opitz Syndrome;Spielmeyer-Vogt Disease;Steroids;Stimulus;Surveillance Program;System;Technology;Testing;Time;tool;Training Programs;Translational Research;treatment trial;Type 7 Spinocerebellar Ataxia;United States National Institutes of Health;Usher Syndrome;Vestibular function;vestibular system;Visualization software;Work

PROJECT_TITLE: Clinical Analysis of Disorders of Hearing and Balance


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Hearing Loss;Neurosciences;Rare Diseases;Regenerative Medicine;Rehabilitation;Usher Syndrome

PROJECT_TERMS: Affect;Animal Model;Animals;Auditory;autosome;Basic Science;clinical center;Clustered Regularly Interspaced Short Palindromic Repeats;Cochlea;deafness;disability;Dizziness;DNA Sequence Alteration;Equilibrium;Gene Delivery;gene therapy;Genes;Genome;genome editing;hair cell regeneration;Hearing;hearing impairment;hearing loss treatment;hereditary hearing loss;Human;improved;Inherited;interest;Labyrinth;mouse model;Mus;Mutation;Natural History;novel;Operative Surgical Procedures;Pathology;Patient Recruitments;Patients;Population;Process;programs;Proteins;Research;transcription factor;Translating;Trauma;United States National Institutes of Health;Usher Syndrome;Vestibular function;vestibular system;WHRN gene

PROJECT_TITLE: Inner ear gene therapy program


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Patient Safety

PI_NAMEs: LEVY, JOSHUA  (contact)

PROJECT_TERMS: 2019-nCoV;Address;Ageusia;Airway Disease;Allergic;Amendment;American;antigen test;Area;aspirin-exacerbated respiratory disease;Attitude;Award;Basic Science;Chronic Sinusitis;Clinic;Clinical;clinical center;Clinical Data;Clinical Practice Guideline;Clinical Protocols;Clinical Research;clinically relevant;Collection;COVID-19 screening;Data;Dinoprostone;Disease;Disseminated eosinophilic collagen disease;Epithelial Cells;Goals;Health;healthy volunteer;Hypersensitivity;Immunology;Immunotherapy;improved;Inflammation;Inflammatory;Inhalant dose form;Institutional Review Boards;interest;Irrigation;Journals;Knowledge;Lead;Liquid substance;Manuscripts;Medical;medical specialties;meetings;Methods;Nasopharynx;National Institute of Allergy and Infectious Disease;National Institute on Deafness and Other Communication Disorders;Natural History;Neurologic;Nose;novel therapeutics;Olfactory dysfunction;Olfactory Epithelium;Operative Surgical Procedures;oropharyngeal swab;Otolaryngology;Participant;Patient Care;Patients;Peripheral;polyposis;programs;Protocols documentation;Provider;Recommendation;Research Personnel;research study;Reverse Transcriptase Polymerase Chain Reaction;saliva sample;Sampling;SARS-CoV-2 B.1.1.529;Sensory Disorders;Signal Transduction;Sinus;Sinusitis;Smell Perception;Societies;Specimen;Surveys;Taste Perception;Techniques;Tissue Sample;Tissues;translational study;Viral Load result;Work

PROJECT_TITLE: Sinonasal and Olfaction Program


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases

PI_NAMEs: BUCHANAN, SUSAN  (contact)

PROJECT_TERMS: Acinetobacter;Antibiotic Resistance;Antibiotics;antimicrobial;Area;Bacteria;Bacterial Outer Membrane Proteins;Bacteriophages;Binding;Binding Proteins;Biochemistry;capsule;Cations;Cells;Citrates;Clinical;Code;colicin;Colicin Ia;Collaborations;Communicable Diseases;Complex;Computer Analysis;crosslink;Cryoelectron Microscopy;Data;design;Development;drug development;drug discovery;Drug Targeting;efflux pump;Electron Microscopy;Electrophysiology (science);Elements;Engineering;Enterobactin;Escherichia coli;experimental study;Family;Generations;Genetic;Gram-Negative Bacteria;Human;Human Genome;in silico;insight;Integral Membrane Protein;interest;Ions;Iron;Klebsiella pneumoniae;Length;Libraries;Lipids;Lower Organism;lysin;Manuscripts;Membrane;Membrane Proteins;Membrane Transport Proteins;Metals;Molecular;Molecular Conformation;molecular dynamics;Motor;Movement;Mutation;nanodisk;nanomachine;National Institute of Allergy and Infectious Disease;Nature;Neisseria;Neisseria meningitidis;new therapeutic target;novel;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Patient Isolation;periplasm;Pesticin;Pharmacologic Substance;Plague;Plasma Proteins;Positioning Attribute;Preparation;protein complex;Protein Engineering;Protein Import;protein structure;Proteins;Proton-Motive Force;Protons;Pseudomonas aeruginosa;Pseudomonas Infections;Pump;receptor;receptor binding;Regulation;Resistance development;Resolution;Roentgen Rays;Role;screening;Serum;Siderophores;Signal Transduction;small molecule;Spectrum Analysis;stoichiometry;Structure;success;Surface;System;Toxin;Transferrin;Transition Elements;Translating;uptake;Vaccines;Virulence;Work;X-Ray Crystallography;Yersinia pestis;Zinc

PROJECT_TITLE: Structural characterization of OM proteins from Gram-negative pathogens


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Nutrition

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: CHOW, CARSON  (contact)

PROJECT_TERMS: Bayesian Analysis;Biological;Communicable Diseases;Complex;COVID-19;COVID-19 pandemic;Data;Data Analyses;Diabetes Mellitus;Diet;Differential Equation;Disease;disease model;dynamic system;epidemiologic data;experimental study;Fat Body;Future;Goals;human model;Immune;Immunologic Memory;Individual;Infectious Agent;Inflammatory Response;Insulin;interest;Lipolysis;Machine Learning;Macronutrients Nutrition;Malignant Neoplasms;mathematical model;Measurement;Metabolism;Methods;Modeling;novel;Obesity;Population;Property;reaction rate;SARS-CoV-2 infection;Sepsis;Serology;Spreading Cortical Depression;System;Techniques;Thinness;Time;Tissues

PROJECT_TITLE: Modeling and data analysis of complex diseases


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Machine Learning and Artificial Intelligence;Neurosciences

PROJECT_TITLE: Analysis of cortical function


NIH_SPENDING_CATS: Diabetes;Nutrition

PI_NAMEs: SHERMAN, ARTHUR  (contact)

PROJECT_TERMS: Action Potentials;Adult;Alpha Cell;Azides;Basic Science;Behavior;Beta Cell;Biophysical Process;Calcium;calcium metabolism;Calcium Oscillations;Cell Respiration;cell type;Cells;Chemicals;Child;Circulation;clinically significant;Communication;Coupled;Coupling;Cyclic AMP;D Cells;Defect;Diabetes Mellitus;Differential Equation;Endocrine;enzyme activity;Enzymes;Exocytosis;experimental study;Feedback;Fructose;gain of function mutation;genome wide association study;Glucagon;Glucokinase;Glucose;glucose metabolism;Glyburide;Glycolysis;Hereditary Disease;Hormone secretion;Human;Hyperinsulinism;Hypoglycemia;Impairment;Individual;Insulin;insulin granule;insulin secretion;interest;Investigation;Ion Channel;ion dynamics;islet;Islets of Langerhans;Journals;Life;Link;Liver;loss of function mutation;mathematical model;Mathematics;Membrane;Metabolic;Michigan;millisecond;Mitochondria;model development;Modeling;neonatal diabetes mellitus;Non-Insulin-Dependent Diabetes Mellitus;Oral;Organ;oxidation;Pancreas;Pathogenesis;Pharmaceutical Preparations;Phase;Physiologic pulse;Physiological;Plasma;Play;Potassium;Protein Kinase C;Published Comment;Publishing;Pyruvate Kinase;Reporting;Respiration;response;Rodent;Role;Signal Pathway;simulation;Sodium Azide;Somatostatin;Stimulus;Structure of beta Cell of islet;Suggestion;Sulfonylurea Compounds;System;theories;Time;Tissues;Tolbutamide;tool;Universities;Wisconsin;Work;Writing

PROJECT_TITLE: Stimulus secretion coupling in pancreatic beta-cells


PROJECT_TERMS: 3-Dimensional;Action Potentials;Adult;Affect;Anterior Pituitary Gland;Astrocytes;Attention;Bioinformatics;Blood Cells;Blood Vessels;Calcium;Calcium Channel;Calcium Signaling;cell type;Cells;Chemicals;Chimeric Proteins;circadian;Code;Communication;comparative;Coupled;Darkness;Data;desensitization;Development;Differential Equation;Discontinuous Capillary;Dose;Embryo;embryonic stem cell;Endocrine;Endoplasmic Reticulum;Endothelial Cells;Enzymes;Exocytosis;Family;Future;G-Protein-Coupled Receptors;Gene Expression Profiling;Generations;Genes;Genetic Markers;Genetic Transcription;Genomics;Gland;gland development;Heterogeneity;Hodgkin Disease;hormonal signals;Hormone secretion;Hormones;Hypothalamic structure;In Situ Hybridization;insulin secretion;intercellular communication;interest;lactotroph;Manuscripts;mathematical model;Mediating;Mediator;Melatonin;Membrane;Membrane Lipids;Microglia;Modeling;National Institute of Child Health and Human Development;Natural regeneration;Nerve;neural;Neuroglia;Neurons;Neurotransmitters;Nobel Prize;notch protein;novel;Organelles;Pattern;pharmacologic;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Physiology;PI3 gene;Pineal gland;Pinealocyte;Pituitary Gland;Pituitary Hormones;Population;postmitotic;postnatal;Preparation;Process;Production;progenitor;programs;Prolactin;Publishing;Quantitative Reverse Transcriptase PCR;Rattus;receptor;Receptor Gene;Resources;Role;Sampling;Second Messenger Systems;SERPINA4 gene;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Solid;Somatostatin;Somatostatin Receptor;somatostatin receptor 3;somatostatin receptor 5;Specificity;stem cell biomarkers;stem cells;Stress;Structure of beta Cell of islet;System;Time;Tissues;tool;transcriptomics;Validation;Vertebrates;Vesicle;voltage;Work;wortmannin

PROJECT_TITLE: Mathematical Modeling of Neurons and Endocrine Cells


NIH_SPENDING_CATS: Bioengineering;Diabetes;Machine Learning and Artificial Intelligence

PI_NAMEs: PERIWAL, VIPUL  (contact)

PROJECT_TERMS: Acute;Address;Biological Models;Bolus Infusion;Cardiovascular Diseases;Clinical;convolutional neural network;Data;Data Set;deep learning;Defect;Development;Diabetes Mellitus;Disease;Enzymes;Glucose;Goals;Hour;Hypertension;in vivo;indexing;Insulin;insulin regulation;Insulin Resistance;insulin sensitivity;Insulin Signaling Pathway;intravenous glucose tolerance test;Lipolysis;Malignant Neoplasms;mathematical model;Mathematics;Methodology;Methods;Mitochondria;Modeling;Modification;neural network;Nonesterified Fatty Acids;Nonlinear Dynamics;novel;Obesity;Output;Performance;physiologic model;Physiological;Plasma;Protocols documentation;Quantitative Evaluations;reconstruction;Regulation;Research;response;Risk Factors;Role;Sampling;Serum;systemic inflammatory response;Techniques;Testing;Time;Tissues;Training;Width;Work

PROJECT_TITLE: Quantitative Estimation of Sensitivity of Lipolysis to Insulin


PI_NAMEs: HALL, KEVIN  (contact)

PROJECT_TERMS: Affect;Agonist;bariatric surgery;Behavior;Biological Sciences;Body Composition;Body Weight;Body Weight Changes;Calories;Clinical;Clinical Management;Clinical Sciences;Complex;Computer Models;Computer Simulation;Continuous Glucose Monitor;Data;design;Eating;energy density;Energy Metabolism;Engineering;experimental study;Food;GLP-I receptor;Glucose;Goals;Human;human model;Intake;interstitial;Intervention;knowledge integration;mathematical model;Mathematical Model Simulation;Metabolic;Metabolic Diseases;Metabolism;Modeling;physical science;Regulation;Research;response;System;Testing;Time;tool

PROJECT_TITLE: Computational modeling of human metabolism, body weight and composition


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Nutrition;Obesity;Physical Activity;Prevention

PROJECT_TERMS: Adult;Affect;Body Composition;Body fat;Body Weight;Body Weight Changes;Carbohydrates;Clinical Research;Clinical Trials;Consumption;Crossover Design;design;Diet;Eating;energy density;Energy Intake;Energy Metabolism;Exercise;Fat-Restricted Diet;Fiber;Food;Human;improved;ketogenic diet;Ketosis;Macronutrients Nutrition;men;Metabolism;nicotinamide riboside supplementation;Obesity;obesity development;Overweight;Physiology;Randomized;randomized placebo controlled trial;Role;Running;Sleep;sugar;Testing;Time;Woman

PROJECT_TITLE: Interactions of diet, exercise, metabolism, and weight change in humans


PROJECT_TERMS: Behavior;Body Composition;Body Weight;Collaborations;cost;data integration;Development;Diabetes Mellitus;Eating;Endocrinology;Energy Metabolism;Human;improved;Investigation;Laboratories;mathematical model;Molecular;mouse model;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Obesity;Organism;Physical activity;Regulation;Rodent

PROJECT_TITLE: Regulation of rodent energy metabolism, body weight and composition


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetics;Human Genome;Women's Health Research

PI_NAMEs: OLIVER, BRIAN  (contact)

PROJECT_TERMS: Adult;Aging;Animals;Atlases;Attention;Biological;Biomedical Research;cell type;Cells;Chemicals;ChIP-seq;Chromatin Structure;Code;Communities;comparative;Computational Technique;Consumption;Data;Deposition;Development;differential expression;Disease;DNA;DNA Sequence;DNA-Binding Proteins;Drosophila genus;egg;Elements;Event;experimental study;Exposure to;FDA approved;Female;follow-up;functional genomics;Gene Expression;gene function;gene interaction;gene network;Genes;Genetic;genetic information;Genetic Models;Genetic Screening;Genetic Techniques;Genetic Transcription;Genome;genome-wide;Genomics;Germ Cells;Germ Lines;gonad development;Gonadal structure;Health;Human;human disease;Human Genome;human model;improved;in vivo;Individual;interest;Investments;knock-down;learning network;literacy;Machine Learning;male;Maps;Measures;Mediating;Methodology;model organism;Molecular Genetics;mutant;network models;novel strategies;Obesity;Outcome;Ovary;Pathway interactions;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Physiology;positional cloning;Process;Protein Isoforms;Proteins;public repository;Reagent;Regulatory Element;Resources;response;RNA Interference;Sex Bias;single-cell RNA sequencing;small hairpin RNA;sperm cell;stem cell function;stem cell model;success;Systems Biology;Testing;Testis;Time;tissue/cell culture;Tissues;tool;Toxic Environmental Substances;transcription factor;transcriptome sequencing;Tumor Stem Cells;Validation;whole genome;Work

PROJECT_TITLE: Drosophila Functional Genomics


PI_NAMEs: LEI, ELISSA  (contact)

PROJECT_TERMS: Acute T Cell Leukemia;Architecture;Area;Beckwith-Wiedemann Syndrome;beta Globin;Binding;Binding Sites;Biology;Bombyx;Bombyx mori;CCCTC-binding factor;Cell Culture Techniques;cell type;Cells;Chromatin;Chromosome Segregation;Chromosomes;Complex;Defect;Development;Disease;DNA;egg;Enhancers;Erythropoiesis;Euchromatin;Event;Future;Gene Expression;Generations;Genes;genetic information;Genetic Transcription;Genome;Germ Lines;Glioma;H19 gene;Heterogeneity;Homeobox Genes;Homologous Gene;IGF2 gene;imprint;Kinetics;Kinetochores;Masks;Meiosis;Metaphase;Microscopy;Microtubules;Moths;multiple omics;Mus;mutant;Nephroblastoma;novel;Nuclear;Oncogene Activation;Organism;postmitotic;Process;promoter;protein complex;Proteins;recruit;Regulation;reproductive success;retinal rods;Rod;segregation;Shapes;Sister;Site;Sorting;Specific qualifier value;Specificity;sperm cell;Spermatogenesis;Structure;System;telomere;Testing;Transcription Repressor;Transcriptional Regulation;transcriptome;Work

PROJECT_TITLE: Chromatin Insulator Function and Nuclear Organization


PI_NAMEs: DEAN, JURRIEN  (contact)

PROJECT_TERMS: Acrosome;Adult;Binding;Biocompatible Materials;Cell division;Cell Lineage;Cell Maintenance;Cells;child bearing;Childhood;chromatin remodeling;cohort;Complex;Congenital Abnormality;Contraceptive methods;Cytokinesis;Cytoplasmic Granules;Dependence;Development;Disease;egg;Embryo;embryo cell;Ensure;Ethics;Event;Exocytosis;exosome;Extracellular Matrix;Female;Fertilization;Gametogenesis;Gene Combinations;Genes;Genome;Germ Cells;Glycoproteins;Growing Follicle;Haploidy;Human;Human Development;human disease;Individual;insight;Investigation;Maintenance;male;Mammalian Oviducts;Mammals;Mediating;Meiosis;Molecular;Molecular Biology;Morphology;mouse model;Mus;natural Blastocyst Implantation;Neonatal;next generation sequencing;Ovary;Ovulation;Patients;piRNA;Polyspermic Fertilizations;Population Growth;postnatal;Pre-implantation Embryo Development;Prevention;Process;Prophase;Proteins;Public Health;reproductive;Reproductive Medicine;Reproductive Technology;Research;Ribonucleases;RNA Helicase;Role;Somatic Cell;Specificity;sperm cell;Spermatocytes;Spermatogonia;Spermiogenesis;stem cell niche;stem cells;Structure;Surface;Taxon;Technology;Testis;Therapeutic;Totipotency;transcription termination;Translations;Zona Pellucida

PROJECT_TITLE: Molecular Biology of Mammalian Gametogenesis, Fertilization and Early Development


NIH_SPENDING_CATS: Genetics

PI_NAMEs: O'CONNELL, KEVIN  (contact)

PROJECT_TERMS: Address;Alanine;Alleles;Area;Autosomal recessive primary microcephaly;Binding;Biochemical;Birth;C2 Domain;Caenorhabditis elegans;Candidate Disease Gene;CCDC6 gene;cell motility;Cell surface;cell type;Cells;Centrioles;Centrosome;Chromosome Segregation;Cilia;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;confocal imaging;Daughter;Defect;Diffusion;Dimensions;Disease;Dwarfism;Embryo;Escherichia coli;Event;Exhibits;Failure;Flagella;Gene Conversion;gene function;Gene Mutation;Generations;Genes;genetic approach;Genetic Screening;genome editing;Genomics;Glutamates;Goals;Growth;In Vitro;Individual;interest;Investigation;kinetosome;Knowledge;Laboratories;Lead;Length;Lesion;Link;loss of function;Maintenance;Maps;Mass Spectrum Analysis;Microtubule-Organizing Center;Microtubules;migration;mimetics;Mitosis;Mitotic;Mitotic spindle;Molecular;molecular phenotype;Mothers;mutant;Mutation;mutation screening;Nematoda;novel;Organelles;overexpression;Phenotype;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;postmitotic;Process;Production;Proteins;Radial;Recombinant Proteins;recruit;Role;scaffold;screening;Serine;Shapes;Signal Transduction;Site;Structure;Suppressor Genes;Suppressor Mutations;Temperature;Threonine;Time;time use;Tissues;Western Blotting

PROJECT_TITLE: Centrosome Maturation and Duplication in the C. elegans Embryo


PI_NAMEs: MASISON, DANIEL  (contact)

PROJECT_TERMS: Affect;Alzheimer's Disease;Amyloid;Amyloidosis;ATP Hydrolysis;Behavior;Binding;Biochemical;Biological Assay;Biophysics;cell growth;Cell Physiology;cell type;Cells;Cellular Stress;Client;cohort;Cytoprotection;Development;Diabetes Mellitus;Disease;Distant;Drug Targeting;Environment;Family member;Goals;Growth;Heat-Shock Proteins 70;Heat-Shock Proteins 90;Human;Impairment;in vivo;insight;interest;Modeling;Molecular;Molecular Chaperones;Molecular Conformation;molecular mechanics;Mutate;Mutation;novel strategies;Organism;Output;paralogous gene;Pathology;Phenotype;Physiological;Play;Point Mutation;Prions;Process;protein folding;protein function;Protein Structure Initiative;Proteins;proteostasis;Quality Control;Reaction;Regulation;response;Role;Site;Solubility;Source;Specific qualifier value;Specificity;Structure;Structure-Activity Relationship;sup35;Supporting Cell;System;targeted treatment;Tertiary Protein Structure;therapeutic candidate;Therapeutic Intervention;Toxic effect;translation factor;Work;yeast genetics;Yeasts

PROJECT_TITLE: Hsp70 and Hsp90 chaperones


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PI_NAMEs: WICKNER, REED B. (contact)

PROJECT_TERMS: Alzheimer's Disease;Amino Acid Sequence;Amyloid;amyloid formation;amyloid structure;Amyloidosis;Architecture;Bacterial Infections;beta pleated sheet;Binding Proteins;Carbon;Cells;Complex;Defect;Diphosphates;Disadvantaged;Disease;DNA;expectation;F-Box Proteins;Filament;Frequencies;Generations;Genes;Genetic;Glutamate-Ammonia Ligase;Glycerol;Growth;Human;human disease;In Vitro;in vivo;Infection;Innate Immune System;Inositol;Learning;Mammals;Mediating;Minority;Mitochondria;Modeling;Molecular Chaperones;Molecular Conformation;mRNA Decay;multicatalytic endopeptidase complex;Mutagenesis;mutant;Mutation;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;non-prion;Normal Cell;overexpression;Parkinson Disease;Pathogenicity;Pathology;Pathway interactions;Polyphosphates;prevent;Prevention;Prion Diseases;prion seeds;prion-like;Prions;Process;Production;Protein Conformation;protein protein interaction;Protein Structure Initiative;Proteins;pyrophosphatase;restoration;Ribosomes;Science;solid state nuclear magnetic resonance;Son;Source;Stress;Structure;System;Testing;Time;transcription factor;ubiquitin-protein ligase;Variant;Virus Diseases;Work;yeast prion;Yeasts

PROJECT_TITLE: Prions of Yeast and Anti-Prion Systems


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

PROJECT_TERMS: Affect;Agreement;Amino Acids;Amyloid;amyloid formation;Cell division;Cells;Cytosol;daughter cell;Dependence;Deposition;Disease;Drug Metabolic Detoxication;Fiber;Generations;Goals;Heat-Shock Proteins 70;Human;In Vitro;in vivo;interest;Liquid substance;Mediating;member;misfolded protein;Molecular;Molecular Chaperones;Monitor;monomer;Mothers;Mutation;N-terminal;Organism;Pathology;Phase;Phenotype;Physiological;Point Mutation;polyglutamine;Prions;Process;Production;Property;protein aggregation;Proteins;PrP;Quality Control;recruit;Role;segregation;sup35;System;Tertiary Protein Structure;Tissues;Toxic effect;transmission process;Work;Yeasts

PROJECT_TITLE: Chaperone-amyloid interactions


PROJECT_TERMS: Affect;Alleles;Autoantigens;Axon;Behavior;Binding;Biogenesis;Biological Assay;Caenorhabditis elegans;Cell Cycle;Cell division;cell type;Cells;Centrioles;Centrosome;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;copolymer;Cytology;Data;Daughter;Defect;design;Development;Embryo;embryo cell;Exhibits;experimental study;Failure;Fathers;Female;follow-up;Genes;genetic analysis;Genotype;Germ Lines;Goals;helicase;Image;interest;Investigation;Knock-out;Label;male;Meiosis;Messenger RNA;MicroRNAs;Microscopy;Microtubule-Organizing Center;Microtubules;Mitosis;Mitotic;Modeling;Mothers;mutant;Mutation;National Heart, Lung, and Blood Institute;Neurons;Nuclear;Organism;Orthologous Gene;overexpression;Pathway interactions;Phenotype;Phosphotransferases;Postembryonic;premature;Process;Production;Protein phosphatase;Proteins;Regulation;response;RNA-Binding Proteins;Role;Sexual Reproduction;sperm cell;Spermatocytes;Syndrome;Temperature;Time;Tissues;Tube;Visit;Work;Zinc Fingers;zygote

PROJECT_TITLE: Developmental Regulation of Centrosome Duplication


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Genetics;Hematology;Infectious Diseases;Neurosciences;Pain Research;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

PI_NAMEs: SCHECHTER, ALAN  (contact)

PROJECT_TERMS: Adhesions;Affect;alpha Globin;alpha-Thalassemia;Anabolism;Anemia;Annual Reports;Archives;Biology;biophysical analysis;Blood coagulation;Blood flow;career;CD34 gene;Cells;Central Nervous System;central sensitization;Cerebral Malaria;Circulation;clinical center;clinical effect;Clinical Research;cohort;Collaborations;Collection;Complex;contrast enhanced;Cyclic GMP;Data;Development;Developmental Biology;Disease;Drug usage;Enzymes;Erythrocytes;Erythroid;Erythroid Cells;Erythropoietin;Exhibits;Fees;Fellowship Program;Festival;Fetal Hemoglobin;Forearm;Functional disorder;Funding;gamma Globin;Gene Expression;Genes;Genetic;Genetic Diseases;Globin;Growth;Head;Hematopoietic;Hemoglobin;Hemoglobin concentration result;Hemolysis;Historical Aspects;Human;hydroxyurea;Impairment;improved;Institution;interest;International;Intramural Research Program;Ions;Journals;Laboratories;Lead;lectures;Life;Malaria;MAP Kinase Gene;Measurement;Measures;Medicine;meetings;member;Metabolism;Modality;Molecular Genetics;mTOR Signaling Pathway;Multicenter Studies;Muscle;Myeloproliferative disease;Myocardial;National Heart, Lung, and Blood Institute;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;Nitrites;novel strategies;novel therapeutics;Oral;Organ;Pain;pain perception;pandemic disease;Pathogenesis;Pathway interactions;Patients;perfusion imaging;Peripheral Nervous System;Pharmaceutical Preparations;pharmacologic;Phenotype;Philosophy;PI3 gene;polymerization;Polymers;Positioning Attribute;Process;Production;programs;Proto-Oncogene Proteins c-akt;Publications;Publishing;Recording of previous events;recruit;Reporting;Research;response;Reticulocyte count;Science;Series;Severity of illness;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;Signal Transduction;symposium;Syndrome;System;Textbooks;Thalassemia;Therapeutic;thrombotic;transcription factor;treatment effect;treatment response;ultrasound;United States National Institutes of Health;Universities;Variant;Work;Writing

PROJECT_TITLE: Control Of the Human Erythrocytic Hemoglobin Phenotype and Approaches to the Therapy of Sickle Cell Disease


NIH_SPENDING_CATS: Hematology;Nutrition;Rare Diseases;Regenerative Medicine;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Women's Health Research

PI_NAMEs: NOGUCHI, CONSTANCE  (contact)

PROJECT_TERMS: Adipose tissue;Adult;Adverse effects;Affect;Age;Age Months;Anemia;Animal Model;Binding;biological adaptation to stress;Biological Assay;blood glucose regulation;bone;bone health;Bone Marrow;Bone Marrow Cells;CD34 gene;Cell Proliferation;Cell Separation;Cell Surface Receptors;Cells;Chronic Kidney Failure;Chronic stress;Combined Modality Therapy;Data;deoxyhemoglobin;Development;Diet;diet-induced obesity;Dose;Embryo;Environmental Risk Factor;EPOR gene;Erythrocytes;Erythroid;Erythroid Progenitor Cells;Erythropoiesis;Erythropoietin;Erythropoietin Receptor;ESR1 gene;Estrogens;Exhibits;Fatty acid glycerol esters;feeding;Female;Fetal Hemoglobin;fracture risk;Gene Modified;Glucose;glucose tolerance;Growth;Guanosine Monophosphate;Hematocrit procedure;Hematopoietic;Hemoglobin;High Fat Diet;Hormones;Human;Human Cloning;hydroxyurea;Hypoxia;improved;In Vitro;Inflammation;inhibitor;insight;Insulin Resistance;interstitial cell;Investigation;Kidney;Knockout Mice;Knowledge;Link;lipid biosynthesis;male;Mediating;Metabolic;Metabolism;Modification;mouse model;Mus;Nitric Oxide;Nitric Oxide Donors;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;NOS3 gene;Obesity;Osteogenesis;Ovariectomy;Oxygen;Pathway interactions;Patients;peripheral blood;pharmacologic;Production;progenitor;Proliferating;protective effect;receptor;Receptor Activation;receptor expression;recombinant human erythropoietin;Regulation;response;Role;sex;Sickle Cell;Sickle Cell Anemia;Signal Pathway;stem cell survival;Thalassemia;Therapeutic;Tissue Survival;Tissues;transcription factor;Transplantation;treatment comparison;Wild Type Mouse;women's treatment

PROJECT_TITLE: Erythropoietin treatment for anemia and hematopoietic/erythroid progenitor cell responses


NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

PROJECT_TERMS: Acute;Adipose tissue;Adult;Affect;Anemia;Animal Model;Animals;Binding;biological adaptation to stress;Biological Assay;Biological Models;Blood Vessels;Body Weight Changes;Brain;Brown Fat;cardioprotection;Cardiovascular system;Cell Proliferation;Cell Survival;Cerebrum;Chronic;Chronic Kidney Failure;Communities;cytokine;Defect;diet-induced obesity;Dose;EFRAC;Endothelial Cells;Energy Metabolism;Erythrocytes;Erythroid;Erythroid Progenitor Cells;Erythropoiesis;Erythropoietin;Erythropoietin Receptor;Estrogens;Exhibits;experimental study;Fatty acid glycerol esters;feeding;Female;Gene Expression;Gene Modified;Genes;Glucose;Heart failure;heart function;Hematocrit procedure;Hemodialysis;High Fat Diet;High Prevalence;Hormones;Human;Hypothalamic structure;Hypoxia;improved;in utero;Inflammation;Injury;insight;Insulin Resistance;Investigation;Kidney;Left;Life;lipid metabolism;Liver;Luciferases;Maintenance;male;Mediating;Metabolic;Metabolism;Morphology;mouse model;Mus;Muscle;Nitrates;Nitric Oxide;Nitric Oxide Signaling Pathway;Nitric Oxide Synthase;Nitric Oxide Synthase Type I;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Ovariectomy;Oxygen;Patients;Phenotype;Pima Indian;Play;Predisposition;Process;Production;Proliferating;promoter;protective effect;receptor;receptor expression;Recombinant Erythropoietin;Regulation;repaired;Reporter Genes;response;RUNX1 gene;secondary analysis;Shortening Fraction;Signal Pathway;Signal Transduction;Skeletal Muscle;stem cell survival;Supplementation;Thinness;Tissue Survival;Tissues;transcription factor;Transgenic Organisms;ubiquitin ligase;Vascular Endothelium;Ventricular;Wild Type Mouse;wound healing

PROJECT_TITLE: Receptor Mediated Erythropoietin Metabolic Response


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Nutrition

PROJECT_TERMS: Acute;Adsorption;Affect;Aging;Animal Experiments;Animal Model;Animals;Arginine;Australia;Back;Biochemical;Biological Assay;Biopsy Specimen;Blood;Blood coagulation;Blood flow;Blood Platelets;Blood specimen;Blood Vessels;bone;Canis familiaris;cardiovascular effects;Cell Culture Techniques;Cessation of life;Chemistry;Chronic;Clinical;clinical application;Clinical Research;clinically significant;Collaborations;Compensation;Cornea;Critical Care;Cyclic GMP;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disease;Dry Eye Syndromes;endothelial dysfunction;Erythrocytes;Exercise;Eye;eye chamber;falls;Family suidae;Food;Frequencies;Functional disorder;genetic manipulation;Glaucoma;Goals;Health Benefit;Hemoglobin;Hormones;Human;human subject;human tissue;Human Volunteers;Hypoxia;improved;Individual;Infusion procedures;Ingestion;Inhalation;inhaled nitric oxide;Institutional Review Boards;Insulin;Insulin Resistance;Ions;Isotopes;Juice;Label;Laboratories;Lacrimal gland structure;Leg;Legal patent;Liver;Lung;Macular degeneration;Mammalian Cell;Mammals;Mass Spectrum Analysis;Measurement;Measures;Medical center;Medicine;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Methods;Muscle;muscle form;muscle physiology;Muscular Atrophy;National Institute of Diabetes and Digestive and Kidney Diseases;Nitrates;Nitric Oxide;Nitrites;Nitrogen;nitrogen metabolism;Nitrogen Oxides;nutrition;Nutritional;Obesity;older patient;Older Population;Ophthalmologist;Ophthalmology;Organ;oxidation;Oxygen;Pathway interactions;Patients;Performance;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physicians;Physiologic Intraocular Pressure;Physiological;Plants;Process;Production;Property;Protocols documentation;Publications;Publishing;Pulmonary Hypertension;Pump;Reaction;Reporting;Rest;Retina;Rodent;Sampling;sarcopenia;Sclera;Sickle Cell;Skeletal Muscle;Study models;Surface;Syndrome;System;Testing;Texas;Thalassemia;Time;Tissues;Tracer;United States National Institutes of Health;Universities;uptake;Variant;vascular bed;volunteer;Writing

PROJECT_TITLE: Clinical Applications of Nitrite and Nitrate


PI_NAMEs: CLORE, MARIUS  (contact)

PROJECT_TERMS: 3-Dimensional;Amyloid;Amyloid beta-Protein;amyloid fibril formation;autosome;Binding;Binding Proteins;Biochemical Process;Biological Process;biophysical techniques;Biophysics;Calcium;Calmodulin;Cell Nucleus;chaperonin;Complex;Computing Methodologies;Darkness;DBL Oncoprotein;Development;Diameter;Disease;DNA;Electron Spin Resonance Spectroscopy;Fingers;Freezing;Genetic Transcription;Goals;HIV Protease;HIV-1;Huntington Disease;Huntington gene;Kinetics;Laboratories;Macromolecular Complexes;macromolecule;Measurement;Measures;method development;Methods;Molecular Chaperones;Molecular Conformation;molecular recognition;Molecular Weight;monomer;Multidimensional NMR Techniques;nanoparticle;Nature;Nerve Degeneration;NMR Spectroscopy;novel;novel strategies;Nucleic Acids;Pathway interactions;Physiologic pulse;Play;polyglutamine;polypeptide;protein complex;Protein Dynamics;protein folding;protein protein interaction;Proteins;Relaxation;Research;RNA-Directed DNA Polymerase;sensor;Signal Transduction;Slide;solid state nuclear magnetic resonance;Spectrum Analysis;Spin Labels;Structure;System;Techniques;Tertiary Protein Structure;Thumb structure;transcription factor;Visualization;Work

PROJECT_TITLE: Structure and Dynamics Of Macromolecules In Solution By NMR


PI_NAMEs: TYCKO, ROBERT  (contact)

PROJECT_TERMS: Address;Amides;Amino Acids;Amyloid;Area;Biological Models;Biopolymers;cold temperature;computer studies;Copper;Data;Dependence;Deposition;Deuterium;Development;Diameter;DNA;Electron Spin Resonance Spectroscopy;Equipment;Evaluation;Evolution;experimental study;Film;Fluorescent Dyes;Freezing;Goals;Helium;HIV-1;Hydrogen;Imaging technology;improved;isopentane;Journals;Letters;Ligand Binding;Liquid substance;Magnetic Resonance;Magnetic Resonance Imaging;mathematical analysis;Measurement;Measures;Metals;method development;Methods;millisecond;Molecular Structure;Nitrogen;NMR Spectroscopy;novel;Nuclear;Nucleic Acids;optical spectra;Paper;Peptides;Physics;Physiologic pulse;Process;protein folding;Proteins;Publications;Publishing;radio frequency;Reporting;self assembly;Series;Signal Transduction;solid state nuclear magnetic resonance;Solvents;Speed;Study models;Surface;tau Proteins;Techniques;Technology;Temperature;temperature jump;Time;Tissues;Torsion;Work;Writing

PROJECT_TITLE: Development of Solid State NMR Methods and Technology


NIH_SPENDING_CATS: Bioengineering

PI_NAMEs: ANFINRUD, PHILIP  (contact)

PROJECT_TERMS: absorption;Active Sites;Affinity;Aluminum;Arctic Regions;Bacteria;base;beamline;Behavior;Binding;Biochemical;Biochemical Reaction;biophysical analysis;Bite;Blood capillaries;Carboxyhemoglobin;Cells;chemical reaction;Chemicals;Code;cold temperature;computer science;Computer software;Computers;data acquisition;Data Set;design;detection platform;digital;Drug Design;Electronics;Ensure;Environment;Enzymes;Equilibrium;Event;Exhibits;Fishes;Genetic Recombination;Head;High temperature of physical object;Higher Order Chromatin Structure;Home;Industry;insight;instrument;kinematics;Laboratories;Lasers;Learning;Life;Light;Lighting;Logic;macromolecule;Measurement;Methods;millisecond;Molecular;molecular scale;Monitor;Motion;movie;novel;novel strategies;Operating System;operation;Optics;Output;Performance;photonics;Physiologic pulse;Population;Positioning Attribute;Postdoctoral Fellow;pressure;Procedures;Process;Productivity;protein structure;Pump;Pythons;Ramp;reaction rate;Resistance;Resolution;Roentgen Rays;Running;Sampling;Semiconductors;Series;Services;Signal Transduction;Site;software development;Source;Spectrum Analysis;Structure;Surface;Syringes;System;Techniques;technology development;Temperature;temperature jump;Testing;Time;Tube;undergraduate student;United States National Institutes of Health;Update;Vent;volunteer;Water

PROJECT_TITLE: Ultrafast Biophysical Studies of Biomolecules at the NIH


NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

PI_NAMEs: BAX, ADRIAAN  (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acceleration;Active Sites;Agreement;Algorithms;alpha helix;aqueous;Binding;C-terminal;Calmodulin;Chemicals;Collection;Data;data acquisition;Data Analyses;Data Set;Databases;Deposition;dynamic system;Equilibrium;experimental study;falls;Four-dimensional;Goals;improved;Ligation;Liquid substance;maltose-binding protein;Measurement;Measures;Methods;Modeling;Molecular Conformation;Molecular Structure;monomer;Motion;mutant;N-terminal;NMR Spectroscopy;novel;Pattern;Peptide Hydrolases;polypeptide;Population;Process;programs;protein data bank;Protein Dynamics;protein structure;Proteins;Residual state;Resolution;restraint;Roentgen Rays;Sampling;SARS-CoV-2 protease;Scheme;Spectrum Analysis;Structure;Suspensions;System;Time;Vertebral column;Virus;X ray diffraction analysis

PROJECT_TITLE: Methods to accelerate protein structure determination by solution NMR


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Orphan Drug;Pain Research;Rare Diseases;Sickle Cell Disease

PI_NAMEs: EATON, WILLIAM  (contact)

PROJECT_TERMS: Abnormal Hemoglobins;Adenosine Triphosphate;Antisickling Agents;Ants;Binding;Biological Assay;Blood;Cell Volumes;Characteristics;Chronic;Clinical Trials;Data Analyses;diphosphoglycerate;Disease;Dose;Drug Kinetics;drug repurposing;Erythrocytes;Fetal Hemoglobin;Fiber;Foundations;Frequencies;Funding;Genes;Hemoglobin;Hemoglobin concentration result;Hemolysis;high throughput screening;Human;hydroxyurea;Individual;inhibitor;Libraries;machine learning algorithm;Measurement;Methods;Microscope;Molecular Conformation;Molecular Disease;molecular drug target;Monitor;Mus;mutant;nanomolar;National Heart, Lung, and Blood Institute;Nitrogen;novel therapeutics;Oral;Organ;Oxygen;Pain;Pathogenesis;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacotherapy;phase 1 study;Phase II/III Clinical Trial;polymerization;Polymers;Pyruvate Kinase;Safety;Sample Size;screening;Serum;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;small molecule;Structure;System;targeted treatment;Testing;Therapeutic;Therapeutic Agents;therapeutically effective;Time;Transgenic Organisms;United States Food and Drug Administration;Whole Blood

PROJECT_TITLE: Sickle cell disease molecular pathogenesis and drug therapy


PROJECT_TERMS: Active Sites;Articular Range of Motion;base;beamline;Biochemical;Biochemical Reaction;biophysical analysis;Cells;chemical reaction;chromophore;Code;Communication;Complement;complex data;Computer software;Computer Systems;Computers;Crystallization;Crystallography;Data;data acquisition;Data Analyses;Data Collection;detector;Development;Electronics;Electrons;Ensure;Enzymes;Equipment;Event;Exhibits;experimental study;Fingerprint;free-electron laser;Generations;Goals;Higher Order Chromatin Structure;Hybrids;improved;Infrastructure;insight;Instruction;Lasers;Learning;Life;Literature;macromolecule;Methodology;Methods;Modeling;Modification;Molecular Conformation;molecular modeling;Motion;Motor;Names;Noise;Operating System;operation;Optics;Output;Pathway interactions;Pattern;Phase;Photons;Physiologic pulse;Physiological;Play;Positioning Attribute;protein function;protein structure;Proteins;Publishing;Pump;Reaction;Records;Reporting;Resolution;Roentgen Rays;Role;Sampling;Secondary to;Shapes;Side;Signal Transduction;Signaling Protein;Site;software development;Source;Specific qualifier value;Spectrum Analysis;Spottings;Structure;Structure-Activity Relationship;Synchrotrons;System;Temperature;Theoretical Studies;Time;virtual;Work

PROJECT_TITLE: Ultrafast Biophysical Studies of Biomolecules at the APS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Nanotechnology;Neurodegenerative;Neurosciences

PROJECT_TERMS: Address;Agreement;Alzheimer's Disease;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid formation;Area;Atomic Force Microscopy;beta pleated sheet;Chemicals;Cryoelectron Microscopy;Darkness;Data;density;Electron Microscope;Genetic Polymorphism;Goals;Growth;Hydrogen Bonding;Journals;Length;Measurement;microscopic imaging;Molecular;Molecular Structure;Morphology;nanometer;neurotoxicity;Paper;Peptides;Physical Chemistry;Polymorph;Proteins;Publishing;Registries;self assembly;Series;solid state nuclear magnetic resonance;Structure;Thick;Transmission Electron Microscopy;Width;Work

PROJECT_TITLE: Structural Studies of Alzheimer's beta-Amyloid Fibrils


PI_NAMEs: JACOBSON, KENNETH ALAN (contact)

PROJECT_TERMS: Address;Adenosine;ADORA2A gene;Affinity;Agonist;Agreement;Alendronate;Amides;Amines;amino group;analog;antagonist;Antineoplastic Agents;Apomorphine;Binding;Binding Sites;Biological;Biological Assay;bone;bone loss;Cardiovascular system;Charge;chemical synthesis;Chemicals;Clinical;Complex;Coupling;Delayed-Action Preparations;Dendrimers;Derivation procedure;design;Detection;Development;Disease;Distal;Docking;Dopamine;DRD2 gene;Drug Carriers;drug discovery;Drug Screening;Drug Targeting;Environment;Enzymes;Exposure to;extracellular;Extracellular Domain;flexibility;Flow Cytometry;Fluorescence Resonance Energy Transfer;fluorophore;Frequencies;functional group;G-Protein-Coupled Receptors;Geometry;Glucose;Glucuronates;GPR105 receptor;Hydrophobicity;Immobilization;improved;Inflammation;inhibitor;Kinetics;Knockout Mice;Knowledge;Laboratories;Length;Ligand Binding;Ligands;Lipids;Malignant Neoplasms;Mediating;Membrane;Membrane Lipids;Metabolic;Methods;Modeling;Modification;Molecular Conformation;molecular modeling;Mus;Mutagenesis;nanocarrier;nanoGold;Nerve Degeneration;novel;nucleobase;nucleotide receptor;Parents;Parkinsonian Disorders;particle;Penetration;Peptides;permissiveness;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;pharmacophore;Phospholipids;Phosphotransferases;PLK1 gene;Polo-Box Domain;Polymers;Positioning Attribute;prevent;Prodrugs;Property;Proteins;Pulmonary Inflammation;Purinergic P1 Receptors;Quantum Dots;radioligand;receptor;receptor binding;Reporter;Research;Roentgen Rays;scaffold;screening;Screening procedure;side effect;Signal Pathway;Site;small molecule;Structure;Structure-Activity Relationship;Surface;Time;tissue injury;Tissues;tool;Transmembrane Domain;Trees;Uracil Nucleotides;Vestibule;Work;Xanthines

PROJECT_TITLE: Functionalized Congeners of Bioactive Compounds