NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Digestive Diseases;Liver Disease;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

PHR: This study will help to discover causes of cholestatic liver diseases, develop new diagnostic tests and markers of disease activity, and develop and test new treatments for infants and children with rare cholestatic liver diseases .

PI_NAMEs: SOKOL, RONALD J. (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Accounting;Alagille Syndrome;alpha 1-Antitrypsin Deficiency;Ancillary Study;Applications Grants;Bile Acid Biosynthesis Pathway;Bile Acids;Bile fluid;Biliary Atresia;Biology;biomarker discovery;cell injury;Cellular biology;Child;Childhood;cholangiocyte;Cholestasis;Chronic;clinical center;Clinical Management;Clinical Research;Clinical Trials;Collection;Colorado;Creativeness;Data;data acquisition;Data Science;Data Set;Defect;Development;Developmental Biology;diagnostic biomarker;Diagnostic tests;Disease;Disease Marker;disease model;DNA;Enrollment;epigenomics;Evolution;Fat-Soluble Vitamin;Funding;Future;Genetic;Genetic Diseases;Genomics;Genotype;Goals;Hepatobiliary;Hepatocyte;Hepatotoxicity;Image;Immune response;Impairment;improved;Infant;Injury;Investigation;Knowledge;Leadership;Liver diseases;Liver Failure;Liver Fibrosis;liver injury;liver transplantation;Los Angeles;Malnutrition;mathematical model;Measurement;member;metabolomics;Mitochondria;Morbidity - disease rate;multiple omics;Natural History;Natural regeneration;Neonatal;neonatal hepatitis;next generation sequencing;novel diagnostics;novel therapeutic intervention;Participant;participant enrollment;participant retention;Pathogenesis;Pediatric Hospitals;Pediatric Research;Phase;Play;Population;Portal Hypertension;primary sclerosing cholangitis;Productivity;Progressive intrahepatic cholestasis;Proteomics;Protocols documentation;Pruritus;Public Health;Publications;Publishing;Request for Applications;Research;research study;response;Role;Scientific Advances and Accomplishments;Services;Site;Specimen;success;Technology;Testing;Therapeutic;translational impact;Translational Research;translational study;Universities;Vitamin Deficiency;Work;Xanthomas

PROJECT_TITLE: Colorado Center of Childhood Liver Disease ResearchNetwork

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-Q (M1)]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Natural Products;Opioids

ORG_CITY: ITHACA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: CORNELL UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The project aims to elucidate and reconstruct the biosynthetic machinery of kratom natural products in yeast for novel non-opioid analgesic development. It will address the longstanding question in plant metabolism about the role plant enzyme complexes play in regulating complicated biosynthesis. This work will provide new methods to discover novel plant complexes and the pathways they organize and ultimately advance pharmaceutical compound biosynthesis for “biased” non-opioid analgesics as the next-generation painkillers.

PI_NAMEs: LI, SIJIN  (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Absence of pain sensation;Acceleration;Address;Anabolism;Analgesics;Biochemical;Biological;Biological Assay;Biology;Candidate Disease Gene;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;cost;dark matter;Development;Electrophoresis;Engineering;enzyme pathway;Enzymes;Escherichia coli;Evaluation;experience;Flow Cytometry;Fluorescence;Fruit;functional genomics;Genes;Genome;Genomics;Goals;Harvest;Indole Alkaloids;Interruption;Knowledge;Libraries;Link;Luciferases;Medicinal Herbs;Messenger RNA;Metabolism;metabolomics;Methods;microbial;Mining;Mitragyna;Monoterpenes;multidisciplinary;Multienzyme Complexes;multiple omics;Natural product discovery;Natural Products;Nature;next generation;non-opioid analgesic;novel;Opioid;Opioid agonist;opioid epidemic;Outcome;Pain;Pathway interactions;Pharmacologic Substance;Plant Genome;Plant natural product;Plant Proteins;Plants;Play;Production;protein protein interaction;Proteins;Reaction;Reader;reconstruction;Regulation;Research;respiratory;Role;screening;side effect;Structure;success;synthetic biology;Technology;Tissues;transcriptome;transcriptomics;Validation;Variant;Work;Yeasts

PROJECT_TITLE: Synthetic biology to discover kratom natural product biosynthetic pathways for biased analgesic development

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Hematology;Infectious Diseases;Sepsis;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: SURGERY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Patients with alcohol use disorder who develop sepsis are significantly more likely to die or have a complicated intensive care unit stay than septic patients without a history of alcohol use disorder. Animal models demonstrate that both gut permeability and the adaptive immune system are disproportionately impacted in septic mice following chronic alcohol ingestion. Understanding mechanisms underlying why mortality is higher in septic hosts with alcohol use disorder may lead to precision medicine approaches to a disease that is common, costly, and highly lethal.

PI_NAMEs: COOPERSMITH, CRAIG M (contact);FORD, MANDY L

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Accounting;Adaptive Immune System;Adhesions;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Animal Model;Animals;Anti-Inflammatory Agents;Antibiotics;Antigens;Apical;Bacteria;Binding;Biological Process;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cecal ligation puncture;Cell Compartmentation;Cells;Cessation of life;Chronic;chronic alcohol ingestion;claudin 4;clinically significant;commensal bacteria;comorbidity;cost;cytokine release syndrome;Data;Dendritic Cells;Diagnosis;Diameter;differential expression;Disease;Down-Regulation;E-Cadherin;effector T cell;Ensure;Epithelial Cells;Epithelium;Equilibrium;FOXP3 gene;Frequencies;Functional disorder;Goals;Heterogeneity;Histology;Homeostasis;Homing;Hospitalization;Immune;Immune response;immunoreaction;Impairment;improved outcome;Infection;Inflammation;Inflammatory;Inflammatory Response;Intensive Care Units;Intestinal permeability;Intestines;Maintenance;Mediating;Mediator;Modeling;mortality;mortality risk;Movement;mucosal site;Mucous Membrane;Mus;MYLK gene;Organ;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patient Admission;patient population;Patients;Permeability;Persons;Phenotype;Play;precision medicine;prevent;Pseudomonas aeruginosa pneumonia;randomized trial;Recording of previous events;Regulation;Regulatory T-Lymphocyte;Role;Sepsis;septic;septic patients;small molecule;Surface;T-Lymphocyte;Testing;Tight Junctions;Time;Tissues;United States;Water

PROJECT_TITLE: The Impact of Chronic Alcohol Abuse on the Pathophysiology of Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation

ORG_CITY: NEW YORK

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative The proposed research is relevant to public health as it aims to develop an objective biomarker for vocal hyper- function, a common symptom in patients with dysphonia. This development is expected to improve diagnosis, treatment outcomes, and quality of life for individuals suffering with voice disorders. Therefore, the proposed re- search aligns with the NIH’s mission to foster innovations that improve health, extend healthy life, and reduce the burdens of illness and disability.

PI_NAMEs: JOHNSON, AARON MATTHEW (contact);SHAHRJERDI, DAVOOD

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: accurate diagnosis;Address;Aftercare;Age;age related;Atrophic;Biological Markers;burden of illness;Caring;clinical practice;Clinical Trials;common symptom;comparison control;Complex;Development;Diagnosis;Diagnostic Procedure;disability;Dose;Dysphonia;Early Diagnosis;effective therapy;Electromyography;Fatigue;Fellowship;Fostering;Foundations;Functional disorder;fundamental research;Future;Gender;Health;improved;Individual;innovation;Intervention;Knowledge;Laryngeal muscle structure;Lesion;Life;Measurement;Measures;Medial;Methods;Mission;Muscle;Muscle strain;Muscle Tension;Myalgia;Neck;neuromuscular;neuromuscular activity;neurophysiology;novel;novel marker;Outcome Measure;Paralysed;Patient Self-Report;Patients;Pattern;precision medicine;predictive tools;Protocols documentation;Public Health;Quality of Care;Quality of life;Reporting;Research;research clinical testing;response;Scanning;sensor;Sensorimotor functions;Series;Solid;Specificity;standard care;standard of care;Surface;Symptoms;Techniques;Testing;Time;Training;treatment as usual;Treatment outcome;treatment planning;treatment response;United States National Institutes of Health;vocal cord;vocalization;Voice;Voice Disorders;voice therapy;Work

PROJECT_TITLE: Functional synergistic perilaryngeal muscle network using synchronized multi-sensor surface electromyography to improve diagnosis and treatment of voice disorders

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Diabetes;Dissemination and Implementation Research;Mental Health;Mental Illness;Pediatric;Prevention

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is a common chronic illness among children requiring a high degree of self-management for good glycemic control. Adolescents are at risk for poor disease management and health outcomes due to a number of factors, including high rates of depression, anxiety, and stress-related, maladaptive eating behavior, which undermine treatment adherence and worsen glycemic control. The current study therefore aims to conduct a pragmatic clinic-based efficacy trial with an additional feasibility of implementation aim utilizing a two-site clinic screening and referral process to a randomized controlled trial of a group-based mindfulness-based intervention, BREATHE-T1D, as compared to a health education condition, HealthEd-T1D.

PI_NAMEs: MACKEY, ELEANOR RACE (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adherence;Adolescence;Adolescent;adolescent health;Affect;Anxiety;anxiety symptoms;Area;attentional control;Behavior;Behavior Therapy;Blood Glucose;Caring;Child;Childhood;Chronic Disease;Clinic;Clinical;Collaborations;Colorado;Continuous Glucose Monitor;coping;critical period;Data;Data Analyses;Depression screen;depressive symptoms;design;Deterioration;Development;diabetes distress;diabetes management;diabetes self-management;Disease Management;Dissemination and Implementation;Documentation;Eating;Eating Behavior;Eating Disorders;effective intervention;efficacy evaluation;efficacy trial;Eligibility Determination;Enrollment;Equity;executive function;experience;Failure;Feasibility Studies;glycemic control;Glycosylated hemoglobin A;Goals;Health;Health education;Hospitals;implementation facilitators;implementation intervention;improved;Impulsivity;Infrastructure;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Learning;Measures;Mental Depression;Methods;mindfulness intervention;Moods;multidisciplinary;negative affect;novel;Outcome;Outcome Assessment;Parents;Participant;Patient Self-Report;Patients;peer;Phase;Pilot Projects;pilot test;pilot trial;Population;Practical Robust Implementation and Sustainability Model;Pragmatic clinical trial;pragmatic trial;primary outcome;Process;programs;Provider;psychosocial;Pump;Qualitative Methods;Randomized;Randomized, Controlled Trials;Reporting;Resources;response;retention rate;Risk;Risk Factors;Rotation;screening;Screening procedure;secondary outcome;Self Care;Self Management;Site;social health determinants;Source;standard care;Stress;Surveys;Symptoms;Teenagers;therapy design;therapy development;Time;Translating;Translations;treatment adherence;Treatment Protocols;trial comparing;Universities;virtual;virtual intervention;Washington;Work;Youth

PROJECT_TITLE: Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth with Type 1 Diabetes

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE Abnormal heart rhythms are a major cause of heart failure, strokes, and death in the US. Our research focuses on how the heart acquires its normal heart rhythm during development, so we can apply this knowledge to better understand why abnormal heart rhythms form in the adult heart. Using this approach, we have identified an essential factor called all-trans retinoic acid (ATRA) and found that ATRA can be used to reverse disease processes in the heart.

PI_NAMEs: PARK, DAVID S (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Acute Promyelocytic Leukemia;Address;Adult;Algorithms;Anti-Arrhythmia Agents;Anti-Inflammatory Agents;aorta constriction;Arrhythmia;Atrial Fibrillation;Attenuated;biological adaptation to stress;Biological Process;Cardiac;Cardiac ablation;Cardiovascular system;cell type;Cells;Cessation of life;Chick;Chromatin;comparative;Complex;Data;Data Set;Development;Disease;dosage;Dose;Electrocardiogram;Enhancers;experimental study;FDA approved;Fibroblasts;Fibrosis;Gene Expression Profiling;Genes;Harm Reduction;Heart;Heart Abnormalities;Heart Atrium;Heart failure;heart rhythm;Human;Hypertension;improved;Inflammation;Inflammatory;inflammatory milieu;intercellular communication;intracardiac pressure;Knowledge;Left;Left atrial structure;Macrophage;Metabolic Pathway;Metabolism;Modeling;Morbidity - disease rate;mortality;mouse model;Multiomic Data;multiple omics;Mus;Muscle Cells;Myopathy;new therapeutic target;novel therapeutics;Nuclear;Nuclear RNA;Pathologic;Pathway interactions;Patients;Physiological;Population;Predisposition;pressure;Prevalence;prevent;Prevention;Process;Public Health;Recovery;Repression;Research;response;Role;side effect;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Specific qualifier value;Stroke;Structural defect;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic target;therapy resistant;Time;tissue regeneration;Tissue-Specific Gene Expression;transcriptome sequencing;transcriptomics;Tretinoin;Vitamin A;Withdrawal

PROJECT_TITLE: Therapeutic Modulation of Atrial Remodeling

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: This is a service-user informed mixed-methods study of the implementation and impacts of the Certified Community Behavioral Health Clinic (CCBHC) program in New York State. Though the model is slated for continued expansion on a national basis, there has been limited research on it and none incorporating service user experience in the research process. By examining the service user perspective alongside rigorous empirical tests of the impact of CCBHCs on utilization and quality of care, this study will provide needed evidence for future implementation of the model.

PI_NAMEs: BRESLAU, JOSHUA A (contact);JONES, GENEVRA

PROGRAM_OFFICER_NAME: FREED, MICHAEL C

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Administrator;Advocacy;Ambulatory Care Facilities;Antipsychotic Agents;Authorization documentation;behavioral health;Caring;Certification;Characteristics;Chronic;Clinic;Clinical Trials;Communities;Community Actions;Community Mental Health Centers;Community Mental Health Services;Congresses;cost;Cost Analysis;COVID-19 pandemic;Data;data resource;design;Development;Evaluation;Evidence based practice;experience;Federal Government;Funding;Future;future implementation;Grant;health care settings;Health Personnel;Health Services;Health Services Research;Healthcare;implementation evaluation;implementation science;improved;Individual;innovation;Institution;International;Interview;Investments;Knowledge;Medicaid;Medical;member;Mental Health;Mental Health Services;Metabolic;Methods;Modeling;Modification;Monitor;National Institute of Mental Health;New York;Organizational Decision Making;Outcome;Outpatients;patient oriented;Patients;Patterns of Care;payment;peer;peer support;Perception;Persons;Pharmaceutical Preparations;Phase;physical conditioning;Play;Policies;Policy Making;Process;programs;prospective;protocol development;Psyche structure;psychosocial rehabilitation;Public Health;Quality of Care;Recording of previous events;Recovery;rehabilitation service;Reporting;Research;Research Personnel;response;Rights;Role;Running;Sampling;scale up;Schizophrenia;Service delivery model;Services;Site Visit;State Government;Statutes and Laws;Structure;Surveys;Testing;Time;Training;United States Dept. of Health and Human Services;Visit;Wages

PROJECT_TITLE: A Service User Informed Study of Certified Community Behavioral Health Center (CCBHC) Implementation and Impact in New York State

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-I (01)]


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

ORG_STATE: MA

PHR: Project Narrative Type I Spiral ganglion neurons (SGNs) process and convey all electrical signal generated in the inner ear to the brain. Of the three known subtypes of SGNs, one is particularly critical for hearing in noisy environments but vulnerable to disconnection and eventual degeneration due to sound overexposure or old age. Here we investigate how the three subtypes of SGNs are generated, focusing on genetic and activity-dependent regulation of their unique identities during development in mice.

PI_NAMEs: SHRESTHA, BRIKHA RAJ (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustics;Acute;acute myeloid leukemia 1 protein;Address;Afferent Neurons;Auditory;Automobile Driving;Back;Behavior;Biological Assay;Biology;Brain;cell type;Cells;Chromatin;Chromosome Mapping;Classification;Cochlea;Code;conditional knockout;Confocal Microscopy;Cues;Deterioration;Development;Down-Regulation;Embryo;Embryonic Development;Environment;Epigenetic Process;epigenetic regulation;epigenome;Epithelium;experimental study;Family member;Gene Expression;Genes;Genetic;genetic corepressor;Genetic Identity;Genetic Transcription;Genome;Genomic approach;genomic locus;Glutamates;Goals;Health;Hearing;hereditary hearing loss;Heterogeneity;human old age (65+);Image;Individual;Injections;Inner Hair Cells;Intervention;Joints;Knockout Mice;Labyrinth;Link;Location;Logic;Maintenance;Maps;Molecular;Morphology;multiple omics;Mus;mutant;Nerve Degeneration;neural;neural circuit;Neuronal Plasticity;Neurons;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 1;Noise;normal hearing;NTRK1 gene;Output;Pattern;Perinatal;postnatal;Process;Production;programs;Property;Proxy;reconstruction;Regulation;reinnervation;Repression;response;runx proteins;RUNX1 gene;segregation;Shapes;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;SLC17A8 gene;sound;Specific qualifier value;Spinal Ganglia;spiral ganglion;Subgroup;Synapses;Tamoxifen;Testing;Time;Tomatoes;transcription factor;Transcription Repressor;transcriptome;transcriptomics;transmission process;Undifferentiated

PROJECT_TITLE: Development and Plasticity of Neural Circuits Underlying Sound Encoding

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE/RELEVANCE TO PUBLIC HEALTH Immunotherapy has revolutionized cancer treatment, but therapy resistance remains a significant problem. One promising strategy to trigger an immune response within tumors and enhance immunotherapy efficacy is by inducing the accumulation of endogenous ‘virus-mimetic’ nucleic acids in cancer cells. We have uncovered a novel viral mimicry-inducing factor, DHX9, involved in the suppression of double-stranded RNAs and RNA/DNA hybrids in cancer cells and aim to study how DHX9 controls these endogenous nucleic acids, as well as targeting DHX9 to enhance antitumor immunity and boost immunotherapy in ‘cold’ tumors, such as Small Cell Lung Cancer.

PI_NAMEs: CANADAS, ISRAEL  (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Ablation;Abscopal effect;anti-tumor immune response;Anti-viral Response;Antitumor Response;Biological Availability;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;Cell Death;Cell Survival;Cells;Clinical;Complex;Data;DNA;DNA biosynthesis;DNA Damage;Double-Stranded RNA;Elements;Enhancers;epigenetic therapy;Event;Genetic Engineering;Genetic Transcription;Genome Stability;Genomic Instability;Genomics;helicase;Hybrids;immune checkpoint blockade;Immune response;Immunocompetent;immunogenic;immunogenicity;Immunologics;Immunotherapy;improved;In Vitro;in vivo;inhibitor;Innate Immune Response;innovation;Interferons;knock-down;lung cancer cell;Maintenance;Malignant Neoplasms;Medicine;Methodology;mimetics;mimicry;Modality;mouse model;Mus;Natural Immunity;neoplastic cell;novel;nucleic acid structure;Nucleic Acids;Oral;Pathway interactions;patient subsets;Public Health;Regulation;replication stress;Resistance;resistance mechanism;Resolution;response;RNA;RNA Processing;RNA Transport;Role;Signal Transduction;small cell lung carcinoma;small molecule inhibitor;success;Testing;Treatment outcome;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Viral;Virus

PROJECT_TITLE: Targeting DHX9 to trigger viral mimicry and immunotherapy responsiveness in Small Cell Lung Cancer (SCLC)

STUDY_SECTION: TIR

STUDY_SECTION_NAME: Therapeutic Immune Regulation Study Section[TIR]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Osteoporosis

ORG_CITY: KANSAS CITY

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MISSOURI KANSAS CITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This research is relevant to public health as it will use state-of-the-art imaging in living cells and live animals to provide novel insights into the dynamic processes by which the bone in our skeletons is built by bone forming cells called “osteoblasts” and is resorbed/reshaped by bone destroying cells called “osteoclasts”. We will for the first time dynamically image the process by which key proteins that form the bone structure are assembled in living bone cells and in live animals and determine in real time how drugs that are used to treat osteoporosis (low bone mass) affect bone cell dynamics and bone resorption dynamics. These studies will significantly advance our mechanistic understanding of the processes of bone formation and resorption and have implications for treatment of osteoporosis, osteogenesis imperfecta and metabolic bone diseases.

PI_NAMEs: DALLAS, SARAH L (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: 3-Dimensional;Address;Affect;aging population;Animals;Automobile Driving;Behavior;Binding;bone;bone cell;Bone Density;Bone Diseases;bone fragility;bone imaging;bone mass;bone metabolism;bone quality;Bone remodeling;Bone Resorption;Bone Resorption Inhibition;Bone Resorption Stimulation;Bone structure;Caring;Cell Communication;Cell Death;cell motility;Cell Physiology;Cells;Cellular biology;Clinical;Collagen;Collagen Fibril;Collagen Type I;Complex;Critical Pathways;Data;Dendrites;dentin matrix protein 1;Deposition;Disease;Drug usage;Extracellular Matrix;Fibronectins;fracture risk;Gene Expression;Genes;Genetic Transcription;Hip Fractures;Image;imaging approach;imaging study;In Situ;In Vitro;in vivo;inhibitor;insight;Institutionalization;intravital imaging;live cell imaging;Maps;mechanical force;Mediating;Metabolic Bone Diseases;migration;mineralization;Molecular;molecular imaging;Molecular Target;Motility;Motion;Movement;multiplexed imaging;Mus;Nature;novel;older patient;Organism;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;Osteogenesis Imperfecta;osteogenic;Osteoporosis;Pathway interactions;Patients;Pharmaceutical Preparations;Physiology;Positioning Attribute;postmitotic;prevent;Process;Proteins;Public Health;Publishing;real-time images;Recording of previous events;recruit;Recycling;Reporter;Research;Resolution;response;scaffold;seal;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Skeleton;Structure;Therapeutic;Time;Tissues;TNFSF11 gene;tool;Transgenic Organisms;Withdrawal;Work

PROJECT_TITLE: Dynamics of Bone ECM Assembly and Resorption

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pachyonychia congenita (PC) is a rare genetic skin disorder caused by mutations in specific keratin genes. PC profoundly alters quality of life owing to, in particular, excruciatingly painful lesions in plantar/palmar skin, and there are no effective treatments available for this condition. This project aims at creating and validating transgenic mouse models that genetically and phenotypically recapitulate PC.

PI_NAMEs: COULOMBE, PIERRE  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acanthosis;Accounting;Affect;Age Months;Alleles;appendage;Area;Bone callus;Characteristics;Chemicals;Clinical Management;Clinical Trials;clinically significant;Code;Complex;Cytolysis;Defect;Dermatologic;Development;Disease;disease model;Distress;Ectoderm;effective therapy;embryonic stem cell;Epidermal Growth Factor Receptor;Epidermis;Epithelium;Equilibrium;Erlotinib;Etiology;Exhibits;Functional disorder;Genes;Genetic;Genetic Models;genetic pedigree;Genome;Goals;Heterozygote;Homeostasis;Hot Spot;Human;Hyperkeratosis;in vivo;Individual;Infection;Inflammatory;inhibitor;insight;Intermediate Filaments;Keratin;keratinocyte;knock out mouse project;Knock-in;Knockout Mice;Knowledge;Laboratories;LacZ Genes;Lead;Lesion;Missense Mutation;mouse model;Mouse Strains;Mus;mutant;mutant mouse model;Mutate;Mutation;Nail plate;novel;novel therapeutics;Open Reading Frames;Oral Leukoplakia;Outcome;Oxidative Stress;pachyonychia congenita;Pain;palliative;Palmoplantar Keratosis;Penetrance;Pharmaceutical Preparations;Phenotype;Phorbol Esters;Population;pressure;Production;Proprotein Convertase 1;Proteins;Quality of life;Rare Diseases;Recurrence;Research Personnel;Sebaceous Glands;Skin;skin disorder;skin lesion;Stress;stressor;Testing;Therapeutic;Thick;Tissues;Topical application;trait;Transgenic Mice;Variant;wound

PROJECT_TITLE: Creating transgenic mouse models that genetically and phenotypically recapitulate pachyonychia congenita

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Human Genome;Immunotherapy;Infectious Diseases;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE We have characterized the recurrent mutations observed in patients diagnosed with large granular lymphocytic leukemia (LGLL). In this project, we determine the functional consequences of those mutations in T- and NK cell models to identify disease-relevant molecular pathways, predictive markers of treatment response, and new targets for therapeutic intervention. The assembled multidisciplinary team is uniquely suited for the proposed work that requires integration of genomic datasets (Ratan, Zang) and genome editing in immune cells (Luckey) with expertise in LGL leukemia biology and an extensive patient registry (Loughran, Feith).

PI_NAMEs: LOUGHRAN, THOMAS P. (contact);RATAN, AAKROSH

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: 2019-nCoV;Acute;Aging;Anemia;Anti-viral Response;Antigens;Architecture;Autoimmune Diseases;Autoimmunity;Azacitidine;Biological Assay;Biological Specimen Banks;Biology;cancer cell;Catalogs;CCL22 gene;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death Induction;Cell Line;Cell model;Cell Therapy;cell type;Cells;Cellular biology;Chromatin;chronic infection;chronic T-cell leukemia;Clinical;clinical heterogeneity;clinical phenotype;Clonal Expansion;combinatorial;Computer Analysis;Cyclophosphamide;Cyclosporine;cytokine;Cytomegalovirus;cytopenia;Cytosine;Cytotoxic T-Lymphocytes;Data;Data Set;Diagnosis;differential expression;Dimerization;Disease;disease heterogeneity;DNA Binding Domain;DNA Methylation;DNA methylation profiling;DNMT3a;DNMT3a mutation;driver mutation;efficacy evaluation;Epigenetic Process;Event;Exhibits;FDA approved;Funding;Gene Expression;Genes;Genetic;genome editing;genomic data;Genomics;Goals;Heterogeneity;Histone Code;histone modification;HIV;Immune;Immune response;Immunosuppressive Agents;improved;ineffective therapies;Infection;Infiltration;Inflammatory;insight;Knowledge;leukemia;Long COVID;loss of function;Malignant Neoplasms;Mass Spectrum Analysis;Memory;Methotrexate;Methylation;methylome;Modeling;Molecular;molecular subtypes;Molecular Target;molecular targeted therapies;multidisciplinary;Multiomic Data;multiple omics;mutant;Mutation;Natural Killer Cells;Neutropenia;new therapeutic target;novel;Outcome;Pathogenesis;Pathway interactions;patient registry;Patient-Focused Outcomes;Patients;predictive marker;Predisposition;Production;programs;Proliferating;Recurrence;Reducing Agents;Registries;Research;Resources;response;Role;Sampling;Signal Transduction;single cell analysis;Site;Somatic Mutation;STAT3 gene;Structure;Surface;T cell differentiation;T-Cell Receptor Genes;T-Lymphocyte;targeted agent;targeted treatment;Therapeutic;Therapeutic Intervention;therapeutic target;therapy resistant;Tissue-Specific Gene Expression;transcription factor;transcriptome;transcriptomics;transition mutation;treatment response;tumor;Tumor-Infiltrating Lymphocytes;Variant;Work

PROJECT_TITLE: Genomic Architecture of LGL Leukemia

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE:  Hypoplastic Left Heart Syndrome (HLHS) is the leading indication for heart transplantation in infancy and is the most common cause of cardiovascular death in infants. With improved understanding of HLHS pathogenesis, the identification of novel therapeutic strategies will serve to decrease costs and improve outcomes for this vulnerable group. The results of this study will establish key mechanisms and modulators of heart failure progression in HLHS and will elucidate a potential therapeutic pathway to mitigate cardiometabolic impairments and progressive cardiac dysfunction in this vulnerable population.

PI_NAMEs: GARCIA, ANASTACIA M (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, BRYANNA NICOLE

PROJECT_TERMS: Adult;Apoptosis;Autocrine Communication;Autophagocytosis;Bioenergetics;Cardiac;Cardiac Myocytes;cardiometabolism;Cardiovascular system;care outcomes;Cell Physiology;Cells;Ceramides;Child;Childhood;Chronic;clinical care;Complex;congenital heart abnormality;cost outcomes;Data;Development;Disease;Failure;Functional disorder;Gene Expression;Glycolipids;Glycosphingolipids;Goals;Healthcare;Heart;Heart failure;Heart Transplantation;hemodynamics;Human;Hypoplastic Left Heart Syndrome;Hypoxia;Immune;Impairment;improved;improved outcome;In Vitro;in vivo;infancy;Infant Mortality;Inflammation;Inflammatory;Lactosylceramides;Life;Liposomes;Longevity;Mediating;Mediator;Membrane Lipids;Membrane Proteins;Metabolic;Metabolic dysfunction;Metabolic Pathway;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Morbidity - disease rate;mortality;multiple omics;Myocardial dysfunction;Myocarditis;Myocardium;neonatal period;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Oxidative Phosphorylation;Oxidative Stress;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Perioperative;Perioperative Care;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Play;Population;Populations at Risk;preclinical study;pressure;Quality of life;rare condition;Resources;respiratory;response;Right Ventricular Hypertrophy;Risk;Role;Signal Transduction;Techniques;Testing;Therapeutic;Tissues;transcriptomics;Ventricular;Vulnerable Populations;young adult

PROJECT_TITLE: Glycosphingolipid-Mediated Cardiomyocyte and Immune Cell Dysfunction in Hypoplastic Left Heart Syndrome

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative Retinoblastoma is a childhood retinal cancer that is thought to develop by forming premalignant lesions in utero, followed by malignant progression and tumor emergence in infants and young children. This project aims to understand how the aberrantly proliferating retinal cells overcome initial barriers to growth, form quiescent premalignant lesions, and later emerge as retinoblastoma tumors. Understanding this process may enable approaches to suppress malignant progression and the development of retinoblastoma in genetically predisposed individuals.

PI_NAMEs: COBRINIK, DAVID  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Address;Adopted;Age;Behavior;cancer predisposition;CDKN2A gene;Cell Cycle;Cell Cycle Checkpoint;Cell Cycle Completion;Cell Proliferation;cell type;Cells;Child;Childhood;cohesion;Cone;Defect;Development;E2F transcription factors;Epigenetic Process;epigenomics;Failure;fetal;Gene Expression;Gene Expression Profile;Genetic Predisposition to Disease;Growth;Hyperplasia;Image;Impairment;improved;in utero;In Vitro;in vitro Model;in vivo;Individual;Infant;knock-down;Knock-out;Knowledge;Label;Lesion;Loss of Heterozygosity;Malignant - descriptor;Malignant Neoplasms;malignant retina neoplasm;Mediating;Mediator;Minority;Mitosis;Mitotic;Modeling;Mutation;MYCN gene;Oncogenic;Organoids;Outcome;Patients;Perinatal;postnatal period;Precancerous Conditions;precursor cell;Predisposition;premalignant;Premalignant Cell;prevent;Process;Production;Proliferating;Proliferation Marker;RB1 gene;response;Retina;Retinal Neoplasms;Retinoblastoma;Retinoblastoma Protein;Series;Signal Transduction;single-cell RNA sequencing;stem cells;success;Testing;Tissues;transcriptomics;tumor;tumorigenesis;Up-Regulation;Xenograft procedure

PROJECT_TITLE: Production and progression of premalignant retinoblastoma lesions.


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: ICAM-1 is an adhesion molecule expressed on the surface of alveolar epithelial cells, endothelial cells, immune cells, and other parenchymal cells that mediates parenchymal cell-leukocyte adhesion and outside-in intracellular signaling through binding to β2 leukocyte integrins during homeostasis and the innate immune response. Studies of ICAM-1 are stymied by the critical need for mice generated by CRISPR/Cas9 technology and for cell-specific Icam1 knockout mice. We are generating mice deficient in ICAM-1 in alveolar epithelial cells or endothelial cells and propose to study the function of both membrane-bound and soluble ICAM-1 in clearance of alveolar surfaces by alveolar macrophages, maintenance of circulating neutrophil counts, sequestration of neutrophils by intravascular inflammatory mediators, and inflammatory and innate immune responses to S. pneumoniae and P. aeruginosa, two common and clinically relevant bacteria that recruit neutrophils through different adhesion pathways, so that we can understand this interesting and critically molecule and assess its potential as a therapeutic target.

PI_NAMEs: DOERSCHUK, CLAIRE M (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;Adhesions;Adhesives;Alleles;Alveolar;alveolar epithelium;Alveolar Macrophages;Bacteria;Binding;Capillary Endothelial Cell;Cell Adhesion Molecules;Cell Communication;cell type;Cells;Chimera organism;clinically relevant;Code;CRISPR/Cas technology;crosslink;cytokine;Cytoskeleton;differential expression;Disparity;Endothelial Cells;Endothelium;Epithelial Cells;ERM protein;Family;Glycoproteins;Homeostasis;homologous recombination;ICAM1 gene;Immune;Immune response;Immunoglobulins;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;Innate Immune Response;Integrins;Intercellular adhesion molecule 1;Interferon Type II;Interleukin-1;Interleukin-8;Knock-out;Knockout Mice;Knowledge;Laboratories;Leukocytes;Leukocytosis;Ligands;Ligation;Lipopolysaccharides;LoxP-flanked allele;Lung;lung microvascular endothelial cells;lung repair;Macrophage;Maintenance;Mediating;member;Membrane;migration;Motility;Mus;Natural Killer Cells;neutrophil;Neutrophil Activation;Neutrophil Infiltration;Oxidants;Pathway interactions;Play;Pneumonia;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa pneumonia;Pulmonary Inflammation;receptor;Recombinant Proteins;Recombinants;recruit;Resolution;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Site;Stimulus;Streptococcus pneumoniae;Surface;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;TNF gene;trafficking;transcription factor;Transcriptional Activation;Up-Regulation;Xanthine Oxidase;XDH gene

PROJECT_TITLE: Uncovering and understanding the many functions of ICAM-1 in the lungs during homeostasis and innate immune responses

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Precision Medicine

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative While current guidelines suggest that restrictive transfusion threshold of 7 to 8 g/dL is safe, this might not be true for patients with different underlying disorders that are less tolerant of anemia. This individual patient data meta-analysis (IPDMA) will establish a comprehensive database with the power and detail to fully explore the effects of transfusion thresholds across clinically important subgroups of patients. The results will inform red blood cell transfusion guidelines and influence clinical care.

PI_NAMEs: CARSON, JEFFREY LEE (contact)

PROGRAM_OFFICER_NAME: SMITH, ERIN E

PROJECT_TERMS: Acute;Acute myocardial infarction;Address;Age;Agreement;Anemia;arm;Cardiac;Cardiac Surgery procedures;Cardiovascular Diseases;Cardiovascular system;Chronic;Chronic Disease;Chronic Kidney Failure;Clinical;clinical care;clinical decision-making;clinical practice;clinical trial analysis;Clinical Trials;comorbidity;Coronary heart disease;cost efficient;Data;Data Pooling;Databases;Disease;Disparate;Effectiveness;Erythrocyte Transfusion;Erythrocytes;falls;Future;Gastrointestinal Hemorrhage;Goals;Guidelines;Heart failure;Hemoglobin;Hemorrhage;high risk population;Hospitalization;Hospitals;human old age (65+);Human Resources;improved outcome;Individual;individual patient;interest;Kidney Failure;Knowledge;Letters;Malignant Neoplasms;Medical;Meta-Analysis;model design;Modeling;mortality;Myocardial Infarction;novel strategies;Outcome;Participant;participant enrollment;patient subsets;Patients;personalized medicine;personalized strategies;Population;primary outcome;Publications;Publishing;randomized trial;randomized, clinical trials;Recommendation;Renal Carcinoma;Research Personnel;Risk;Risk Factors;Risk Reduction;Safety;Sample Size;secondary outcome;Series;sex;Specific qualifier value;Subgroup;Techniques;text searching;Therapeutic;Transfusion;treatment effect;trial comparing;Update;Work

PROJECT_TITLE: Individual Patient Data Meta-Analysis of Red Blood Cell Transfusion Trials Comparing Liberal versus Restrictive Thresholds

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Transplantation

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The R01 renewal focuses on refining the Non-Invasive Venous waveform Analysis for Heart Failure (NIVAHF) device, a tool developed for non-invasive monitoring of volume status in heart failure patients. Through a series of detailed aims, the project intends to overcome its discovered limitations by better understanding how the device's signals are influenced by conditions such as tricuspid regurgitation, post-heart transplantation, and the presence of a left ventricular assist device. By leveraging advanced statistical analyses and machine learning, this research aims to optimize the clinical utility of the NIVAHF device for these specific patient subsets, ensuring more accurate and timely detection of complications.

PI_NAMEs: ALVIS, BRET D (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: Achievement;Address;Affect;Algorithms;Analysis of Covariance;artificial intelligence algorithm;beneficiary;Blood Vessels;Calibration;Cardiology;Caring;Characteristics;CHRM3 gene;Clinical;comorbidity;Complex;Complication;Data;Data Collection;Data Set;Databases;Detection;Development;Devices;Diagnosis;Disease Marker;Early Diagnosis;Early identification;Enrollment;Ensure;Equipment Malfunction;Exhibits;experimental study;Family suidae;Frequencies;Generations;graft dysfunction;graft failure;Graft Rejection;Health;Heart failure;Heart Transplantation;hemodynamics;Human;human subject;improved;improved outcome;innovation;insight;Left;left ventricular assist device;Liquid substance;Longevity;Machine Learning;Measures;Monitor;monitoring device;Network-based;neural network;neural network algorithm;non-invasive monitor;Outcome;patient subsets;Patients;Pattern;Peripheral;personalized care;post-transplant;pressure;Prevalence;Pulmonary Capillary Wedge Pressure;Pulse Rates;Quality of life;Research;Research Proposals;rho;Series;Severities;Severity of illness;Side;Signal Transduction;simulation;Statistical Data Interpretation;Study Subject;Survival Rate;tool;transplant database;Transplant Recipients;Tricuspid Valve Insufficiency;Venous;Work

PROJECT_TITLE: Non-Invasive Venous waveform Analysis (NIVA) for Monitoring Volume Status in Heart Failure Patients

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE This proposal aims to study pathways that lead to environmentally-associated social anxiety symptoms in Black and Latinx youth living in the context of economic disadvantage, a population that is at high risk for mental health problems but has been underrepresented in neuroimaging research. We propose to investigate effects of prenatal exposure to air pollution on risk for social anxiety symptoms through studying effects of prenatal exposure to air pollution on behavioral inhibition, a marker of social anxiety, and brain function underlying cognitive control, a risk factor for social anxiety in children with behavioral inhibition. The long-term goal is to inform development of novel prevention and interventions programs for social anxiety in youth living in the context of economic disadvantage, and to promote interdisciplinary developmental team science in which the wider mental health system has the skills to work together to improve the health and development of vulnerable children.

PI_NAMEs: FOX, NATHAN A;MARGOLIS, AMY  (contact)

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Age;aged;Air Pollutants;Air Pollution;ambient air pollution;Animal Model;Anterior;Anxiety;Anxiety Disorders;anxiety symptoms;Aromatic Polycyclic Hydrocarbons;avoidance behavior;Behavior;behavior observation;Behavioral inhibition;Birth;Black race;Brain;Brain region;Child;Child Behavior;Child Behavior Checklist;Child Development;Childhood;cingulate cortex;cognitive control;cohort;comorbidity;Conflict (Psychology);Country;Data;Detection;Development;developmental psychology;Disadvantaged minority;economic disparity;Electroencephalography;Environment;Environmental Health;epidemiology study;ethnic minority population;Exposure to;Future;Goals;Health;Health system;high risk;Human;Impairment;improved;Individual;individualized prevention;Infant;information processing;Intervention;intervention program;Latinx;Link;marginalized population;Measures;Mediating;Mediation;Mental Health;Modeling;Monitor;neural;neuroimaging;Neurophysiology - biologic function;Neurosciences;neurotoxic;novel;Nursery Schools;Outcome;Parents;Pathogenicity;Pathway interactions;Performance;physical conditioning;Population;prenatal;prenatal exposure;Prevention;Prevention program;Prevention strategy;prospective;Public Health;Questionnaires;racial minority population;Reporting;Research;Risk;Risk Factors;Risk Reduction;Role;Sampling;School-Age Population;Schools;Science;skills;social anxiety;Social Anxiety Disorder;Social isolation;Socioeconomic Status;Structure;Symptoms;Temperament;Testing;Third Pregnancy Trimester;Time;Toxic Environmental Substances;Withdrawal;Work;Youth

PROJECT_TITLE: Prenatal Exposure to Air Pollution and Childhood Social Anxiety Symptoms: Novel pathogenic pathways

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Prevention;Primary Immunodeficiencies;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_DEPT: DERMATOLOGY

PHR: NARRATIVE Although hidradenitis suppurativa (HS) is a common condition, particularly in Black patients and women, and impacts qualify of life more severely than almost any other skin disease, there is currently limited understanding of the genetic factors that contribute to disease risk and severity. Our initial genetic study of 720 HS patients combined with patient data in biobanks identified genetic variants that contribute to the risk of developing HS and that may affect the genes SOX9 and KLF5 to influence wound healing, inflammation, and the maintenance of the skin and hair follicles. In addition to studying how the recently discovered genetic variants affect HS, we will use a larger genetic study of 2,000 patients and more biobanks to identify more variants affecting HS, including any related to ancestry and disease severity, which may help predict risk of disease progression and reveal new targets for treatments.

PI_NAMEs: LI, YUN ;MOHLKE, KAREN L.;SAYED, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Adolescence;Adolescent;Affect;Age of Onset;American;biobank;Bioinformatics;Biological;Biological Assay;Biology;black patient;Black Populations;Black race;black women;Blood specimen;Candidate Disease Gene;candidate identification;cell type;Cells;Characteristics;Chromatin;chronic inflammatory disease;chronic inflammatory skin;chronic wound;Clinic;Clinical;Clinical Trials;cohort;comorbidity;Country;Cutaneous;Data;Dermatologic;Dermatologist;design;Development;Disease;Disease Progression;disorder risk;Disproportionately impacts women;DNA;DNA analysis;Early Intervention;Epidermis;epigenome;experience;Family member;Functional disorder;Funding;gamma secretase;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Gene Proteins;Genes;Genetic;genetic architecture;Genetic study;Genetic Transcription;genetic variant;genome wide association study;genome-wide;Genotype;Goals;Hair follicle structure;Heritability;Hidradenitis Suppurativa;Human;Immunohistochemistry;improved;Inflammation;Inflammatory Response;keratinocyte;Learning;Lesion;Link;Maintenance;men;Meta-Analysis;North Carolina;novel therapeutic intervention;Odds Ratio;Outcomes Research;Pathogenesis;Pathogenicity;Pathway interactions;Patient Recruitments;Patients;Persons;Phenotype;Play;Population;prevent;Prevention strategy;programs;protein expression;Proteins;Publishing;Quality of life;Recurrence;Registries;Regulatory Element;Reporter;Reporting;repository;Research;Risk;risk prediction;risk variant;Role;Saliva;Sample Size;Sampling;secondary analysis;Severities;Severity of illness;sex;Siblings;single-cell RNA sequencing;Skin;skin disorder;Skin Tissue;Specimen;Structure;Subgroup;Symptoms;Therapeutic;therapeutic target;Tissue Sample;Tissues;transcriptome;transcriptome sequencing;treatment response;Universities;Untranslated RNA;Validation;Variant;Woman;wound healing;young adult

PROJECT_TITLE: Determining the Genetic Basis of Hidradenitis Suppurativa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-G (90)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Women's Health Research

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative The rising rates of maternal morbidity and mortality in the United States demand answers. The obstetric outcomes of hemorrhage and infection, which contribute to maternal mortality, and cesarean delivery in low- risk women, which increases maternal and neonatal morbidity risk, vary widely across hospitals and are marked by stark disparities between Black and non-Black women. The overarching goal of the proposed research is to improve maternal health and reduce maternal health disparities by developing actionable evidence about the influence of changes in labor and delivery nursing unit organizational characteristics (work environment, nurse workload, percentage of registered nurses with a Bachelor of Science in Nursing degree) on these three obstetric outcomes and disparities in these outcomes.

PI_NAMEs: LAKE, EILEEN T (contact);SRINIVAS, SINDHU K

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Academy;Address;Birth;Black race;care providers;Caring;Cesarean section;Characteristics;Childbirth;Clinical;cohort;Data;Data Set;Databases;Decision Making;design;Discipline of Nursing;Discipline of obstetrics;Disparity;disparity reduction;Education;Exhibits;Experimental Designs;Future;Geography;Goals;Guidelines;Health;Health Care Costs;health disparity;health equity;Healthcare Systems;Hemorrhage;Hospital Administrators;hospital care;Hospitalization;Hospitals;improved;infant morbidity;Infection;Inpatients;Intervention;Investigation;Link;Literature;Longitudinal Studies;Maternal Health;maternal morbidity;Maternal Mortality;Measures;medical specialties;Medicine;microsystems;Mission;Monitor;Mothers;neonatal morbidity;Neonatal Nursing;novel;Nurses;obstetric care;Obstetric Delivery;obstetric outcomes;Obstetrical Nursing;Organization administrative structures;Outcome;outcome disparities;Patient Discharge;patient population;Patient-Focused Outcomes;Patients;Perinatal;Policies;policy implication;Policy Making;Population;post-pandemic;Postpartum Hemorrhage;Preparation;Prevention;professional atmosphere;Professional Organizations;programs;Quality Indicator;Quality of Care;Race;Recommendation;Reduce health disparities;Registered nurse;Reporting;Research;Resources;Risk;Safety;Sampling;Science;Surveys;Testing;Time;Translating;United States;United States National Institutes of Health;Variant;Washington;Woman;Women's Health;Workload

PROJECT_TITLE: Effects of Changes in Labor and Delivery Nursing Organizational Characteristics on Obstetric Outcomes and Disparities

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  After loss of vestibular (inner ear balance) sensation, some patients ultimately recover enough to perform daily activities, but many fail to fully compensate and remain disabled by chronic imbalance and the inability to see clearly while moving. This research project will identify the neural mechanisms that underlie how the brain adapts to changes in vestibular input and will advance development of an implantable bionic inner ear device that can help restore quality of life to thousands of individuals disabled by unilateral and bilateral loss of vestibular sensation.

PI_NAMEs: CULLEN, KATHLEEN E (contact);DELLA SANTINA, CHARLES C

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Acute;Address;Adult;Advanced Development;Animals;Attenuated;Behavior;Behavioral Paradigm;Bilateral;Bionics;Brain;Cells;Central Nervous System;Chronic;clinical care;Clinical Trials;CNS processing;Compensation;Complex;Conflict (Psychology);design;Devices;disabled;Disabled Persons;Disabling;Electric Stimulation;Ensure;Equilibrium;Esthesia;evidence base;Exhibits;experimental study;Eye;first-in-human;Foundations;Frequencies;functional improvement;Funding;Gait;gaze;Goals;Head;Head Movements;Human;human subject;Impairment;Implant;improved;innovation;insight;Investigation;Labyrinth;Learning;Life;Locomotion;Macaca mulatta;Mechanics;Mediating;Methods;Modeling;Monkeys;Motion;Motor;motor learning;Movement;multimodality;Musculoskeletal Equilibrium;neural;neural circuit;neuromechanism;Neuronal Plasticity;Neurons;neurophysiology;Neurosciences;nonhuman primate;Pathway interactions;Patients;Performance;Phase;Physiologic pulse;Physiology;Population;Positioning Attribute;Posture;posture instability;Primates;Probability;programs;Prosthesis;Protocols documentation;Publications;Pulse Rates;Quality of life;Recovery;recruit;Reflex action;Research;Research Project Grants;Research Project Summaries;response;restoration;Running;sample fixation;Sensory;sensory input;sensory integration;sensory system;Signal Transduction;Solid;Speed;Stimulus;Symptoms;System;Technology;Testing;Time;translational impact;United States;Vertigo;Vestibular function;Vestibular loss;Vestibular Nerve;Vestibular nucleus structure;vestibular pathway;vestibular prosthesis;vestibular reflex;vestibular system;vestibulo-ocular reflex;Vision;Visual;Walking

PROJECT_TITLE: The Physiology of Vestibular Compensation

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative  Despite intensive research, the etiology leading to neuronal cell loss in Parkinson’s diseases (PD), Alzheimer’s diseases and related dementias remains unknown. Genome wide association studies (GWAS) have identified numerous sequence variants associated with the risk to develop sporadic PD, however, there is little insight regarding which and how these risk variants mechanistically contribute to the development and progression of PD, thus impeding the clinical use and the development of novel therapeutics based on these data. This proposal aims to systematical identify and define the molecular and cellular mechanisms how GWAS-risk variants contribute to the development and progression of neurodegenerative diseases.

PI_NAMEs: SOLDNER, FRANK  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Affect;Aging;alpha synuclein;Alzheimer's Disease;Alzheimer's disease related dementia;Automobile Driving;Autophagocytosis;Autopsy;base editing;Biological;Biology;Brain;brain tissue;Cell Nucleus;cell type;Cells;Chimera organism;Chronic;Clinical;Coculture Techniques;Complex;CRISPR/Cas technology;cytokine;Data;Development;Diagnosis;Disease;Distal;Elements;Enhancers;Environmental Risk Factor;Epidemiology;Epigenetic Process;Etiology;experimental study;gain of function;Gene Expression;Gene Expression Profile;gene function;Genes;Genetic;genetic association;Genetic Enhancer Element;Genetic Risk;Genetic Transcription;genome editing;genome wide association study;genome-wide;Genomic Segment;glial activation;Goals;Human;human pluripotent stem cell;Impairment;In Vitro;Inflammasome;Inflammatory;Inflammatory Response;insight;Lead;Lewy Body Dementia;Link;loss of function;Maps;Mediating;member;Microglia;migration;Modeling;Molecular;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;neuroinflammation;neuron loss;neuronal survival;Neurons;novel;novel therapeutics;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern Recognition;Phagocytosis;Pilot Projects;Play;Population Genetics;prime editing;Probability;Process;protective allele;protein aggregation;Protein Family;Proteins;Regulation;Regulatory Element;Research;response;Risk;risk variant;Role;sensor;Signal Pathway;Signal Transduction;Sorting;sporadic Parkinson's Disease;synuclein;synucleinopathy;System;Testing;Therapeutic;Tissue Sample;tool;Untranslated RNA;Up-Regulation;Upstream Enhancer;Variant;Work

PROJECT_TITLE: The Role of GPNMB in Parkinson's Disease.

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: NEW HAVEN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Atherosclerosis underlies the leading cause of death in industrialized societies. During atherogenesis, the accumulation of apolipoprotein B containing lipoproteins (LDL and VLDL) in the matrix beneath the endothelial layer of blood vessels leads to the recruitment of monocytes, cells of the immune system that give rise to macrophages and dendritic cells. Macrophages derived from recruited monocytes participate in a maladaptive non-resolving inflammatory response that expands the subendothelial layer due to the accumulation of cells, lipids, and matrix. This proposal aims to investigate the contribution of TMEM86 enzymes in regulating phospholipid remodeling and plasmalogen-derived active lipids mediators in macrophages. We will define how plasmalogen metabolism regulated by TMEM86a controls macrophage immunometabolic responses during the progression of atherosclerosis.

PI_NAMEs: FERNANDEZ HERNANDO, CARLOS  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Antioxidants;Aorta;Apolipoproteins B;Apoptosis;Arterial Fatty Streak;atherogenesis;Atherosclerosis;Binding;Binding Proteins;Biogenesis;Blood Vessels;Bone Marrow;Cardiometabolic Disease;Cardiovascular Diseases;Cause of Death;Cell Nucleus;Cells;Cholesterol;Cholesterol Homeostasis;Choline;Chronic;Collagen;Complex;cytokine;Data;Dendritic Cells;Development;Eicosanoids;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Enzymes;Ethers;Family;fatty acid biosynthesis;fatty acid metabolism;fatty acid oxidation;Fatty Acids;fatty aldehyde;Foam Cells;Gene Expression;Gene Expression Profiling;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;glycerophosphoethanolamine;Glycerophospholipids;Health;High Density Lipoproteins;Histologic;Homeostasis;Human;Hydrolysis;Immune system;Induction of Apoptosis;Industrialization;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Integral Membrane Protein;Laboratories;Lesion;Leukotrienes;Link;lipid mediator;lipid metabolism;Lipid Peroxidation;lipidome;lipidomics;Lipids;Lipoproteins;Lipoxins;Liver X Receptor;Low-Density Lipoproteins;Lysophospholipids;Macrophage;Maintenance;Mediating;Membrane;Membrane Fluidity;Metabolic;Metabolism;metabolomics;MicroRNAs;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Necrosis;Neurodegenerative Disorders;novel;Nuclear Receptors;Output;Pathway interactions;Peritoneal;Phagocytosis;Phospholipase A2;Phospholipid Metabolism;Phospholipids;Physiology;Plasmalogens;Play;Polyunsaturated Fatty Acids;Process;Production;programs;Proliferating;Prostaglandins;Reaction;receptor;recruit;Regulation;Resolution;response;Response Elements;Rest;reverse cholesterol transport;Role;Signal Pathway;Signal Transduction;Societies;Sterol Biosynthesis Pathway;Sterols;Structure of brachiocephalic artery;Subendothelial Layer;systemic inflammatory response;Techniques;Thick;Time;transcription factor;Transcriptional Regulation;transcriptomics;Transplantation;uptake;vascular inflammation;Very low density lipoprotein;vinyl ether;Work

PROJECT_TITLE: Contribution of novel lysoplasmalogenases enzymes in regulating macrophage immunometabolic responses in cardiovascular disease

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE Heart disease is the leading cause of morbidity and mortality in the United States and across the world, and cardiac fibrosis is one of the most detrimental factors for a variety of heart disease including hypertrophy and heart failure. However, an efficient therapy for fibrosis-associated heart disease is still an unmet need. We propose to investigate novel mechanisms of cardiac fibrogenesis and to identify potential new therapeutic targets for developing better therapy for fibrosis-associated heart diseases.

PI_NAMEs: YUE, LIXIA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: aorta constriction;Biochemistry;Calcium Signaling;candidate marker;Cardiac;coronary fibrosis;Data;disease model;effective therapy;Effector Cell;Fibroblasts;fibrogenesis;Fibrosis;Gene Knock-Out Model;Goals;Heart;Heart Diseases;Heart failure;Human;hypertensive;Hypertrophy;Image;In Vitro;in vivo;Infarction;inhibitor;innovation;insight;interdisciplinary approach;ischemic injury;Knock-in;Knock-in Mouse;Left ventricular structure;Mediating;Mediator;Modeling;Molecular Biology;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Ischemia;Myofibroblast;new therapeutic target;novel;novel therapeutic intervention;Oxidative Stress;patch clamp;Pathologic;Pathway interactions;Patients;Permeability;Phosphotransferases;Play;pressure;Prognostic Marker;protective effect;receptor;Reporting;Research;Role;side effect;Signal Pathway;Signal Transduction;Stimulus;System;Testing;Therapeutic;therapeutic target;Transforming Growth Factor beta;Transgenic Mice;United States

PROJECT_TITLE: Calcium Signaling Mechanisms in Cardiac Fibrogenesis

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ODESSA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS OF THE PERMIAN BASIN

ORG_STATE: TX

PHR: Project Narrative The goal of this proposal is to elucidate the novel mechanism underlying the pathogenesis of amyotrophic lateral sclerosis (ALS). Based on our novel findings, we hypothesize that the mitochondrial carrier protein PSAP plays a regulatory role in mitochondrial quality control, apoptosis, and autophagy pathways, thereby contributing to the pathogenesis of ALS and other neurodegenerative diseases . The elucidation of the molecular mechanisms underlying the pathogenesis of ALS will facilitate the development of preventive and therapeutic strategies .

PI_NAMEs: XU, XUEMIN  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Aging;Amyotrophic Lateral Sclerosis;Apoptosis;Apoptotic;Astrocytes;Autophagocytosis;Carrier Proteins;CASP3 gene;Cell Culture System;Cell Line;Cell Surface Receptors;Cells;Cessation of life;Coculture Techniques;Cognitive;Complex;Data;Dementia;Development;Disease;Disease Progression;DNA Sequence Alteration;effective therapy;extend lifespan;Gliosis;Goals;Homeostasis;Impairment;In Vitro;in vivo;Inclusion Bodies;Induction of Apoptosis;Inhibition of Apoptosis;innovation;insight;Knock-out;Knockout Mice;Lead;Mediating;Membrane Proteins;Mitochondria;Molecular;motor function improvement;motor neuron degeneration;Motor Neurons;mouse model;MTCH1 gene;Mus;Muscular Atrophy;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuromuscular Junction;neuronal survival;neuroprotection;new therapeutic target;novel;Onset of illness;Outer Mitochondrial Membrane;Paralysed;Parkin;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Phosphorylation;Physiological Processes;Play;Preventive;pro-apoptotic protein;Process;protein function;protein TDP-43;Proteins;Quality Control;receptor;Regulation;release factor;Research;Risk Factors;Role;Signal Pathway;Spinal Cord;Stress;success;superoxide dismutase 1;System;Testing;Therapeutic;therapy development;Toxic effect;treatment strategy;Ubiquitination;Voltage-Dependent Anion Channel

PROJECT_TITLE: Novel role of mitochondrial carrier protein PSAP in regulation of both apoptosis and autophagy in ALS

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

PHR: Project Narrative  The black-legged tick, Ixodes scapularis, transmit several pathogens, including Anaplasma phagocytophilum, the causative agent of human anaplasmosis. Survival in the vector in different developmental stages of ticks is particularly important for intracellular microbes, such as A. phagocytophilum, that cannot be transovarially transmitted. In this study, we propose to characterize the role of tick molecules such as organic anion transporting polypeptide (OATP), Xanthurenic acid (XA), tryptophan pathway and microRNAs in A. phagocytophilum survival and transmission from these medically important vectors.

PI_NAMEs: NEELAKANTA, GIRISH  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Active Immunization;Address;Affect;Anaplasma phagocytophilum;Anaplasmosis;Antibodies;Arthropod Vectors;Arthropods;Aryl Hydrocarbon Receptor;Bacteria;Binding;Biological Assay;Black-legged Tick;Cell Death;Cells;Data;design;Development;differential expression;Enzymes;FDA approved;Funding;Gene Expression;Gene Expression Regulation;Genes;Goals;Grant;Human;Hypothetical Protein;Immunization;Immunize;Impairment;Infection;Ingestion;inhibitor;Interruption;Journals;knock-down;Kynurenine-oxoglutarate aminotransferase;Lead;MAP Kinase Gene;Mediating;Medical;Messenger RNA;Microbe;MicroRNAs;Modeling;Molecular;Molecular Analysis;Mus;Natural Immunity;novel;OATP Transporters;overexpression;p38 Mitogen Activated Protein Kinase;Passive Immunization;pathogen;Pathway interactions;Peer Review;Pharmaceutical Preparations;Play;prevent;promoter;Proteins;Publications;Publishing;Reactive Oxygen Species;Recombinants;Regulation;Reporting;Research;Rickettsia;RNA Interference;Role;Salivary Glands;success;tick bite;tick transmission;Ticks;Time;tool;Transcript;transcription factor;Transcription Factor AP-1;Transcriptional Activation;Transcriptional Regulation;transmission process;Tryptophan;Tryptophan Metabolism Pathway;United States;Validation;vector;vector transmission;Virus;Xanthurenic Acid

PROJECT_TITLE: Anaplasma Phagocytophilum Modulate Tick Gene Expression for its Survival and Transmission from the Vector Host

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE This study is to optimize the inhibition of BACE1, known as β-site amyloid precursor protein, for reducing both amyloid plaques and subsequent tau pathology. We aim to investigate how to inhibit BACE1 together with enhancing microglial function for reducing AD pathologies. The obtained results will eventually be used to develop safe BACE1 inhibitors and modulator for microglia function for AD treatment.

PI_NAMEs: YAN, RIQIANG  (contact)

PROGRAM_OFFICER_NAME: PETANCESKA, SUZANA

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Abeta clearance;Abeta synthesis;Address;Adult;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Amyloid deposition;Apolipoprotein E;Astrocytes;autocrine;Behavior;Behavioral;beta-site APP cleaving enzyme 1;Biological Assay;Biology;Brain;Breeding;Cell Nucleus;Cells;Chemicals;chemokine;Chemotactic Factors;Clinical Trials;Cognitive deficits;cognitive function;conditional knockout;Coupled;CXCL14 gene;Data;Data Set;Disease associated microglia;Dose;Enzymes;Excision;experimental study;functional improvement;Funding;Gene Expression;Generations;glial cell development;Growth;Human;IL1R2 gene;Immune;improved;inhibitor;Knowledge;Learning;Mediating;Memory;Microglia;migration;Mitogen-Activated Protein Kinase Kinases;Modeling;Molecular;Monitor;mouse model;Mus;Neurofibrillary Tangles;Neuroglia;neuron loss;Neurons;novel;p38 Mitogen Activated Protein Kinase;paracrine;Pathogenesis;Pathology;Pathway interactions;Phagocytes;Phagocytosis;promoter;Publishing;Recombinants;response;Role;RXR;Senile Plaques;side effect;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;sulfated glycoprotein 2;Synapses;Tamoxifen;tau aggregation;tau Proteins;Testing;Tetanus Helper Peptide;Therapeutic;TLR2 gene;TLR4 gene;Toll-like receptors;Toxic effect;transcriptome sequencing;Transgenic Mice;Transgenic Model;Up-Regulation

PROJECT_TITLE: Inhibition of BACE1 for benefiting Alzheimer's patients

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission in the central nervous system, while their disfunction is associated with devastating psychiatric, neurological, and neurodegenerative disorders, including schizophrenia, depression, autism, amyotrophic lateral sclerosis, epilepsy, and Alzheimer’s disease. We aim to study heteromeric assembly, noncompetitive inhibition, and ion channel block of AMPA and kainate subtypes of iGluRs using a combination of biophysical and biochemical approaches. Our results will advance understanding of iGluR structure and function and guide structure-based drug design.

PI_NAMEs: SOBOLEVSKY, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acids;Adamantane;Alzheimer's Disease;AMPA Receptors;Amyotrophic Lateral Sclerosis;antagonist;anti-epileptic agents;autism spectrum disorder;Binding;Binding Sites;Biochemical;Biophysics;Bipolar Disorder;Calcium;Calcium Channel Blockers;Cells;Central Nervous System;Chemical Structure;Chemicals;Clinical;cognitive process;Complex;Cryoelectron Microscopy;Data;Dementia;Dependence;design;Development;Disease;drug candidate;Drug Design;drug development;Drug Targeting;efficacious treatment;Electrophysiology (science);Epilepsy;Excitatory Postsynaptic Potentials;experience;experimental study;Family;feasibility research;Fluorescence;Functional disorder;Future;Generations;Glutamate Receptor;Goals;Green tea;Homo;Huntington Disease;inhibitor;Ion Channel;ion channel blocker;Ischemia;kainate;Kainic Acid Receptors;Knowledge;Learning;Mediating;Memory;Mental Depression;Mental disorders;Mental Retardation;Methods;Modeling;Modernization;Molecular;molecular modeling;Molecular Structure;Mood Disorders;Mutagenesis;nervous system development;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Symptoms;neuropathology;neurotransmission;neurotransmitter release;next generation;novel;Obsessive compulsive behavior;Pain;patch clamp;Permeability;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Play;Polyamines;Positioning Attribute;Protocols documentation;Publishing;receptor;reduce symptoms;Regulation;Research;Schizophrenia;side effect;Specificity;Structure;Synaptic plasticity;Synaptic Receptors;Techniques;Testing;Therapeutic;Toxin;Traditional Medicine;trafficking;Transmembrane Domain

PROJECT_TITLE: Structure and Function of Ionotropic Glutamate Receptors

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: NARRATIVE The healing response within the myocardium after a myocardial infarction (MI) is complex and involves both temporal and regional changes including inflammation, cardiac scar formation, and tissue remodeling. Over the last decade the importance of the spleen has been highlighted as a reservoir for the majority of monocytes trafficking to the heart in response to ischemic damage. In this proposal, we will utilize advanced nanomaterials as tools to localize inhibitors to the spleen to dissect the mechanisms by which HDACs modulate the cardiac inflammatory affect after MI.

PI_NAMEs: MCCARTHY, JASON R.;MENICK, DONALD R. (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TITLE: Biomimetic nanomaterials for the immunomodulation of the cardiosplenic axis post-myocardial infarction

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Infectious Diseases;Microbiome;Sexually Transmitted Infections

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Human papillomaviruses (HPV) cause 5% of human cancers. While there are highly eﬀec>ve, prophylac>c HPV vaccines, their poor uptake in the US combined with the fact that they do not treat exis>ng persistent infec>ons or the cancers arising from those pre-exis>ng infec>ons necessitates that we con>nue eﬀorts to learn how to eliminate persistent HPV infec>ons and the cancers they cause. These are the goals of this grant.

PI_NAMEs: LAMBERT, PAUL F. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: animal model development;Cancer Etiology;carcinogenesis;chronic infection;Disease;epithelial stem cell;Estrogens;experimental study;Faculty;Funding;Generations;Genes;Genome;Goals;Grant;Human;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immunity;Immunotherapy;innovation;insight;Knowledge;Learning;Malignant Neoplasms;medical schools;Merkel Cells;microbiome;microbiome alteration;mouse model;Mus;next generation;Oncogenic Viruses;Papillomavirus;Papillomavirus Infections;Pathogenesis;Polyomavirus;Positioning Attribute;Process;Productivity;programs;prophylactic;Public Health;Publications;Research;Resistance;Role;Scientist;Sexual Transmission;Training;Transgenic Mice;tumor;Universities;uptake;virology;Wisconsin

PROJECT_TITLE: Defining Drivers of HPV-associated Carcinogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-E (M1)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Thalamic circuits are dominated by two sources of inhibition that influence the type and quality of information that relay cells transmit from eye to brain. Here we use an interdisciplinary approach that combines diverse experimental techniques with theory and computation to explore how inhibition contributes to local and global feature processing in thalamus. Understanding how thalamic circuits operate is key to understanding sensory integration per se, and, moreover, serves studies of disorders such as amblyopia or the development of visual prosthetics by providing a blueprint for how healthy brains function.

PI_NAMEs: HIRSCH, JUDITH A (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Amblyopia;Anatomy;Axon;Brain;Cannulas;Cell Nucleus;cell type;Cells;comparative;Complex;computer framework;Data Set;density;design;Diffuse;Disease;Dorsal;Electrodes;experimental study;Eye;Feedback;Felis catus;Foundations;Frequencies;Future;Goals;Image;Individual;insight;interdisciplinary approach;interest;Interneurons;Interruption;Lateral Geniculate Body;Learning;Link;luminance;Mammals;Maps;model development;Modeling;Mus;neural;neural circuit;neuronal cell body;Neurons;Noise;Ocular Prosthesis;Opsin;Optics;optogenetics;orientation selectivity;Output;Pathway interactions;Pattern;Physiological;Positioning Attribute;preference;Primates;Property;receptive field;response;Reticular Cell;Retina;retinotopic;Sampling;selective expression;sensory integration;Shapes;Site;Source;spatiotemporal;Stimulus;Structure;Synapses;Synaptic Transmission;Techniques;Thalamic Nuclei;Thalamic structure;theories;Thinness;Time;tool;Training;Transfection;transmission process;vesicular release;Viral;Vision;vision development;Visual;visual information;visual processing;Visual System;Voice

PROJECT_TITLE: Neural Circuits that Process Visual Information

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative This research project will use micro- and macro-scale anatomical and physiological brain imaging techniques to identify biological mechanisms of cognitive decline in people with multiple sclerosis (MS). We will explore the link between neuronal integrity and alterations in brain networks across different stages of MS. This research will provide insight into novel therapeutic targets to treat cognitive impairment in MS and, in addition, tools that can be used by clinicians to predict patients at risk for cognitive decline.

PI_NAMEs: GAUTHIER, SUSAN A (contact);KUCEYESKI, AMY FRANCES

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Agreement;Anatomy;Atrophic;Automobile Driving;Binding;Biological;Brain;Brain imaging;cerebral atrophy;Chronic;Clinical;clinical application;clinically relevant;Cognition;Cognitive;cognitive function;cognitive performance;cohort;Data;design;Diffusion Magnetic Resonance Imaging;Disease Progression;effective therapy;exhaustion;experience;Flumazenil;Functional Magnetic Resonance Imaging;Future;Goals;gray matter;Health;high risk;Image;imaging approach;imaging biomarker;imaging modality;Imaging Techniques;Impaired cognition;Impairment;Individual;Inflammation;insight;Link;Magnetic Resonance Imaging;Measures;Methods;Microscopic;mild cognitive impairment;Modeling;Multimodal Imaging;multimodality;Multiple Sclerosis;multiple sclerosis patient;Neurobehavioral Manifestations;Neurobiology;neuroimaging;neuron loss;Neurons;new therapeutic target;novel therapeutics;Pathology;Patients;Pattern;personalized medicine;Pharmacologic Substance;Physiological;Positron-Emission Tomography;predictive modeling;preservation;prevent;Publications;receptor;receptor density;receptor function;Relapsing-Remitting Multiple Sclerosis;Research;Research Project Grants;resilience;response;Risk;serial imaging;Severities;Structure;Testing;therapeutic development;Therapeutic Intervention;Time;tool;treatment strategy;Up-Regulation;white matter;white matter damage;Work

PROJECT_TITLE: Multi-scale, multi-modal imaging assessment of trajectories of cognitive impairment in Multiple Sclerosis

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

PHR: A SYSTEMS THEORY APPROACH TO THE STUDY OF COLON AND LUNG CANCER HEALTH  DISPARITIES USING NOVEL DATA LINKAGES Project narrative/relevance African Americans and rural Americans are disproportionately affected by both cancer incidence and mortality with little progress made in narrowing the gap with their white or urban counterparts. With this application, we will combine unique data sources to create a population-based, racially, socio-economically, and geographically (urban versus rural) diverse cohort of men and women to examine targeted therapies, comorbidities, and multi-level contributors to survival disparities for colon and lung cancers. We will convene an advisory board of community leaders, organizations, and clinicians to identify multi-level and modifiable targets for intervention.

PI_NAMEs: ADAMS, SWANN ARP (contact);BELL, NATHANIEL

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Address;Adherence;Affect;African American;African American population;Age Years;American Cancer Society;Area;Behavioral;Biological;Breast Cancer survivor;Cancer Burden;cancer care;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer site;cancer survival;Cancer Survivor;cancer therapy;cohort;Colon;colon cancer patients;Colon Carcinoma;Color;Colorectal Cancer;Communities;community advisory board;community partners;community partnership;comorbidity;cost;Data;data integration;Data Linkages;data resource;Data Sources;data warehouse;Databases;Decentralization;Diabetes Mellitus;Diagnosis;Disease;Disparity;Excess Mortality;experience;Failure;Future;Geography;Goals;health record;Health system;improved;Incidence;Individual;Infrastructure;innovation;Interdisciplinary Study;Intervention;Investigation;Joints;Knowledge;life span;Link;Literature;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;meetings;men;Mental Depression;Mental Health;Minority Groups;minority health;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;neoplasm registry;new therapeutic target;novel;opioid use disorder;Outcome;Participant;Pattern;Persons;Physical environment;Policies;Population;population based;Race;racial diversity;Records;Research;Resources;Rural;rural Americans;rural area;rural disparities;rural dwellers;rural patients;Rural Population;Science;social culture;Socioeconomic Status;socioeconomics;Source;South Carolina;Structure;survival disparity;survival outcome;Survivors;System;Systems Theory;targeted treatment;Translating;treatment and outcome;treatment disparity;treatment effect;Treatment outcome;Woman;women of color;Work;young cancer survivor

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Congenital Structural Anomalies;Genetics;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

PHR: Chronic kidney diseases such as Goodpasture's disease, Alport syndrome, and diabetic nephropathy damage the ultrafilter causing kidney failure. We study the molecular architecture and function of the collagen scaffolds that comprise the normal filter and which are damaged by these diseases. The knowledge gained provides a framework to develop new forms of therapy.

PI_NAMEs: BUDKO, SERGEY PETROVICH;HUDSON, BILLY GERALD (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: 3-Dimensional;Achievement;Address;Affect;Agrochemicals;Animal Experiments;Antibodies;Architecture;Atomic Force Microscopy;Autoantibodies;Autoantigens;Autoimmune Diseases;Basement membrane;Binding;Biological Assay;Cell Culture Techniques;Chlorides;Chronic Kidney Failure;COL4A3 gene;Collagen;collagen scaffold;Collagen Type IV;Complex;CRISPR/Cas technology;Cryoelectron Microscopy;Crystallization;Data;Deuterium;Development;Diabetic Nephropathy;Disease;Electron Microscopy;environmental chemical;Environmental Risk Factor;environmental tobacco smoke exposure;Enzymes;Etiology;Exposure to;Genes;Genetic;genetic risk factor;genetic variant;glomerular basement membrane;glomerular filtration;Glucose;Hereditary nephritis;Home;Hydrogen;insight;Integrins;Kidney;Kidney Failure;Knowledge;Label;Lung;Lung Diseases;macromolecule;Maps;Mass Spectrum Analysis;Medical;Modification;Molecular;Mutate;Negative Staining;neoantigens;Pathogenicity;Persons;pressure;Production;Protein Isoforms;protein purification;Proteins;Protomer;Publishing;rational design;receptor;Receptor Cell;Recombinants;reconstruction;Roentgen Rays;scaffold;Scanning Electron Microscopy;Structure;targeted treatment;therapy design;therapy development;Tissues;tool;transcriptome sequencing;Transmission Electron Microscopy;triple helix;Variant

PROJECT_TITLE: Studies on the structure of basement membranes

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Nutrition;Prevention;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Narrative.  Cerebral small vessel disease (CSVD) is a leading cause of vascular dementia and stroke. We have previously identified a genetic risk factor associated with CSVD which then was confirmed in multiple different manifestations of the disease implicating polyamines as the potential explanation of the association. To prove it, we are measuring levels of the different forms of polyamines and looking at the brain imaging manifestations of CSVD. If positive, there are both dietary and pharmacologic interventions that may be used to reduce risk in the future. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: DEMEL, STACIE ;LANGEFELD, CARL D;PAREDES, DANIEL A;WOO, DANIEL  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 1q22;Acetylation;Acetyltransferase;Acrolein;African ancestry;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;biracial;Blood specimen;Blood Vessels;blood-brain barrier disruption;brain health;Brain hemorrhage;Brain imaging;cardiovascular risk factor;Cardiovascular system;Cells;Cerebral hemisphere hemorrhage;Cerebral small vessel disease;Child;Chromatography;Cognitive;cohort;Data;Data Set;deep sequencing;detection method;Development;dietary;Dietary History;Diffusion Magnetic Resonance Imaging;Disease;disease phenotype;DL-alpha-Difluoromethylornithine;Enhancers;Enrollment;Environmental Risk Factor;Etiology;European;Evaluation;Excision;Fluorescence;follow-up;Food;Funding;Future;Gene Expression;Genes;genetic association;Genetic Risk;genetic risk factor;genome wide association study;genome-wide;Genomics;Grant;gut microbiota;Hemorrhage;high risk;high risk population;Infarction;Inflammation;Intervention;Intervention Studies;Ischemic Stroke;Label;Lasers;Lead;Literature;Magnetic Resonance Imaging;Measurement;Measures;Mediation;Mediterranean Diet;Metabolism;metabolomics;Neurocognitive;neurotoxicity;Not Hispanic or Latino;novel;Ohio;Orphan Drugs;Oxidative Stress;Parkinson Disease;Participant;Pathway interactions;pharmacologic;Pharmacology;Phenotype;Polyamines;Population;progressive neurodegeneration;promoter;Prospective, cohort study;protective effect;Proteins;rare variant;Recording of previous events;recruit;Research Personnel;Risk;Risk Factors;Risk Reduction;RNA;Sampling;Source;Spermidine;Spermine;Stroke;Target Populations;Techniques;Testing;Time;tractography;transcription factor;trend;Variant;Vascular Cognitive Impairment;Vascular Dementia;White Matter Hyperintensity

PROJECT_TITLE: Genetic and Environmental Risk Factors for Hemorrhagic Stroke – V

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE Many patients with gynecologic cancer experience treatment-related sexual health concerns but do not raise these concerns with their clinicians due to a lack of preparation for how to do so effectively. The objectives of the proposed study are to evaluate the efficacy of a patient-focused intervention designed to promote clinical communication about sexual health for patients with gynecologic cancer (Starting the Conversation – Gynecologic Cancer; STC-GC), to test intervention mediators, and to obtain qualitative data from patients and clinicians to contextualize and interpret quantitative findings of the trial. This study has public health relevance because enhancing gynecologic cancer patients’ communication about sexual health would directly impact clinical care and could improve patients’ sexual and psychological health.

PI_NAMEs: REESE, JENNIFER BARSKY (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;arm;Arousal;Behavioral Model;Belief;Body Image;Breast Cancer Patient;cancer care;Cancer Intervention;Cancer Patient;Cancer Survivor;care delivery;Caring;chemotherapy;Clinic;Clinical;clinical care;Clinical Practice Guideline;Code;Communication;comparison control;cost;Data;dissemination trial;Distress;efficacy evaluation;efficacy trial;Emotional;empowerment;Evidence based intervention;Expectancy;expectation;experience;Feeling;follow-up;Fostering;Future;Genitalia;Health;health communication;Hysterectomy;Impairment;improved;innovation;insight;Intervention;intervention effect;Interview;Investigation;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Measures;Mediating;Mediation;Mediator;Medical;Mental Health;Methods;neglect;novel;Oncology;Operative Surgical Procedures;Outcome;Pain;patient population;Patient Self-Report;Patients;Pelvic floor structure;Pelvis;Physiological;pilot test;pilot trial;Population;post intervention;Preparation;psychological distress;public health relevance;Radiation;Randomized;Randomized, Controlled Trials;recruit;Reporting;Research;resource guides;Sampling;Self Efficacy;Sex Functioning;Sexual Health;skills;social cognitive theory;surgery outcome;Target Populations;Testing;theories;therapy design;therapy development;tool;Training and Education;treatment as usual;United States National Institutes of Health;Vagina;vaginal dryness;Woman;women patients;Work

PROJECT_TITLE: Promoting Effective Clinical Communication about Sexual Health after Gynecologic Cancer: A Randomized Controlled Trial of a Patient-Focused Intervention

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Abdominal Aortic Aneurysm (AAA) carries an enormous human toll and is characterized by macrophage- overactivation that causes profound degradation of the aortic matrix accelerating rupture and mortality. We observed that within the AAA microenvironment, increased local tension activates Cdh11 which exerts strategic control of aortic macrophage reprograming capable of collapsing the aortic tissue. Our experiments will detail mechanisms connecting Cdh11 and pathologic macrophage function in AAA by using mice models of macrophage proliferation, lineage, plasticity and newly designed drug targeting Cdh11 coupled with state-of-the- art sequencing approaches in human samples to thoroughly delve into new treatment approaches urgently needed to treat individuals with AAA.

PI_NAMEs: RAMKHELAWON, BHAMA  (contact)

PROGRAM_OFFICER_NAME: STABLEY, JOHN N

PROJECT_TERMS: abdominal aorta;Abdominal Aortic Aneurysm;Acceleration;Address;Aorta;Aortic Aneurysm;Aortic Rupture;autocrine;Behavior;Binding;Blood Vessels;cadherin-11;Cadherins;Cause of Death;Cell Proliferation;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;Chronic;Clinical;clinically relevant;Clonal Expansion;Clonality;Colony Stimulating Factor Activation;combat;Coupled;CRISPR/Cas technology;cytokine;Defect;Development;Dilatation - action;Drug Design;Drug Targeting;efficacy testing;Epitope Mapping;experimental study;Extracellular Matrix;Extracellular Matrix Degradation;Fibroblasts;Fostering;Funding;Goals;Human;Immune;immune checkpoint;Immunophenotyping;improved;In Vitro;in vitro Assay;Incidence;Individual;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;interest;Letters;Link;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor;Maps;Matrix Metalloproteinases;Mechanics;Mediating;Membrane;MMP3 gene;Modeling;Molecular;mortality;mouse model;Mus;novel;novel therapeutic intervention;NTN1 gene;Operative Surgical Procedures;Outcome;overexpression;paracrine;Pathogenicity;Pathologic;Pathology;Pathway interactions;permissiveness;Pharmaceutical Preparations;Phenotype;Piezo 1 ion channel;Play;prevent;Proliferating;Protein Isoforms;Proteolysis;receptor;Research;response;Role;Rupture;Sampling;Severities;Shapes;Signal Transduction;single-cell RNA sequencing;Site;small molecule inhibitor;Solid;spatiotemporal;Testing;Therapeutic Intervention;Tissues;trafficking;trait;transcription factor NF-AT c3;transcriptome;transcriptomics;Transgenic Mice;Variant;Vascular Diseases;Vascular remodeling;Verteporfin;Work

PROJECT_TITLE: Spatiotemporal checkpoints of macrophages in aortic aneurysms- Renewal

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]