NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Mono-allelic antigen receptor gene expression is a hallmark of adaptive immunity that ensures mono-specificity of B and T cells. The applicant discovered that signals emanating from antigen receptor gene assembly on one allele transiently feedback inhibit this process on the other allele to help achieve mono-allelic expression. The applicant presents new preliminary data that identifies two components that might govern inter-allelic control of antigen receptor gene assembly. The applicant proposes experiments to elucidate underlying mechanisms for each component and test their roles in enforcing mono-allelic antigen receptor gene assembly and expression.

PI_NAMEs: BASSING, CRAIG H (contact)

PROJECT_TERMS: adaptive immunity;Alleles;Antigen Receptors;Area;ataxia telangiectasia mutated protein;ATM deficient;ATM Signaling Pathway;Autoimmunity;B-Lymphocytes;Binding Sites;Biology;cell type;Cells;Chromosomes;Data;DNA;DNA Double Strand Break;Double Strand Break Repair;Elements;endonuclease;Ensure;Exclusion;experimental study;Feedback;Frequencies;Gene Expression;Gene Expression Regulation;Genes;Genetic Recombination;Genetic Transcription;Genomics;IgK;Immune response;insight;Knowledge;Lymphocyte;Malignant lymphoid neoplasm;Mediating;Methods;Modeling;mouse model;Mus;NF-kappa B;novel;nuclease;Pattern;Process;promoter;protein phosphatase inhibitor-2;Proteins;Rag1 Mouse;receptor;Receptor Gene;repaired;Repression;Research;response;Role;Signal Pathway;Signal Repression;Signal Transduction;Signaling Protein;T-Cell Receptor;T-Lymphocyte;Testing;thymocyte;Time;Transcriptional Regulation;Untranslated RNA;V(D)J Recombination;Work

PROJECT_TITLE: Elucidating Mechanisms of RAG Endonuclease Mediated Feedback Inhibition of V(D)J Recombination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-E(02)]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health

ORG_CITY: LOS ANGELES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Integrative multidisciplinary science training is much needed to understand and address the complex relationships of biological, behavioral, and sociocultural processes in their contribution to the crucial public health problems of mental disorders as well as psychological and physical health disparities in the population. The proposed training will produce a cohort of scientists for the next generation of cutting-edge basic and translational research.

PI_NAMEs: DUNKEL SCHETTER, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TITLE: Biobehavioral Issues in Physical and Mental Health


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Approximately one-third of pharmaceuticals target a single large class of proteins, the G-protein coupled receptors. This same receptor superfamily is used by olfaction to detect chemicals. This proposal aims to develop a system-wide understanding of the relationship between receptors and the chemicals they detect, and may lead to new principles for understanding how to model or target these receptors.

PI_NAMEs: HOLY, TIMOTHY  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Afferent Neurons;Amino Acids;Animals;Behavioral;blind;Calcium;candidate identification;carboxylate;cell type;Cells;Characteristics;chemical binding;Chemicals;Code;Collection;Color Visions;combinatorial;computerized tools;Cues;Data;Decision Making;Detection;Development;Disadvantaged;Ectopic Expression;Equipment and supply inventories;Exhibits;Family;feature detection;flexibility;Food;functional group;G-Protein-Coupled Receptors;Genes;Goals;Harvest;Human;Image;In Vitro;Individual;insight;Laboratories;Length;Ligand Binding;Ligands;Light;Link;Maps;Measures;member;Microscopy;Modeling;Molecular;Molecular Conformation;Mutagens;novel;Olfactory Pathways;olfactory receptor;Optics;Output;Partner in relationship;Pharmacologic Substance;pharmacophore;Physiological;Population;predicting response;Property;Proteins;receptor;Receptor Activation;Receptor Gene;response;Retinal Cone;Role;screening;Sensory;sensory system;Sequence Homology;Site;Smell Perception;Specificity;Steroids;Stimulus;Structure;Structure-Activity Relationship;Sulfate;System;Techniques;Testing;tool;Vertebral column;Volatilization;vomeronasal organ;Vomeronasal Systems;Work

PROJECT_TITLE: Mechanisms of chemosensory recognition

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Pediatric;Social Determinants of Health

ORG_DEPT: GENETICS

PHR: NARRATIVE The creation of holistic K-12 programs that spark student interest in science, empower their academic pursuits, and provide them with bona fide research experiences is essential to enhance the migration of talented, STEM-focused, minoritized students into college STEM majors. Such efforts are essential for the U.S. to realize the immense latent scientific potential contained within its diverse population. By leveraging partnerships with community K-12 organizations and listening to the needs of our partners and their students, we have sculpted a new, integrated program that will provide holistic training and support to minoritized, low- income high school students to help them succeed in STEM.

PI_NAMEs: SKEATH, JAMES BENJAMIN;WYLIE, KRISTINE M. (contact)

PROGRAM_OFFICER_NAME: MANN KOEPKE, KATHY M

PROJECT_TERMS: Academic support;Address;Affect;African American student;Age;Bachelor's Degree;Baltimore;Biomedical Research;Black American;Black Populations;career;Career Choice;career preparation;Child;college;Communities;computer science;County;demographics;Doctor of Philosophy;doctoral student;Education;Education Gap;Educational workshop;empowerment;experience;Genome;genome sciences;Genomics;Goals;Graduation Rates;Hand functions;health disparity;high school;High School Student;Hispanic Americans;Human Genome Project;interest;K-12 student;Lead;Leadership;Learning;literacy;Low income;Maryland;Mathematics;matriculation;Mentors;migration;Minority;minority student;minority undergraduate;Modernization;Motivation;Native Americans;next generation;outreach;Parents;Population;Population Heterogeneity;Postbaccalaureate;Poverty;programs;Qualifying;Research;Research Project Grants;role model;Running;school district;School-Age Population;Science;Science, Technology, Engineering and Mathematics Education;Scientist;stem;STEM career;STEM field;student mentoring;student participation;Students;success;Talents;Training;tutoring;twelfth grade;undergraduate student;Underrepresented Minority;Underrepresented Students;United States;Universities;Washington

PROJECT_TITLE: WASHINGTON UNIVERSITY SCIENCE PARTNERSHIP PROGRAM - BUILDING STEM CAREER READINESS IN K-12 STUDENTS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Infectious Diseases

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PI_NAMEs: OROZCO, ROBIN C. (contact)

PROJECT_TERMS: Address;Alleles;Amino Acid Substitution;antiviral immunity;Arginine;assay development;Binding;Biological;Biology;C-terminal;Cells;Chemicals;Chronic;Communicable Diseases;Computer Analysis;cytokine;Data;Disease;Enzymes;experimental study;Flow Cytometry;Funding;Future;Goals;Health;Immune;Immunology;in vivo;Individual;inhibitor;interest;Kansas;Length;Libraries;Molecular;Mus;Mutation;Myeloid Cells;N-terminal;novel;novel therapeutics;Peptides;Phenotype;Production;Protein Tyrosine Phosphatase;Proteins;PTPN22 gene;rational design;Role;Specificity;Structure;therapeutic target;tool;Tryptophan;Universities;Viral Physiology;Virus Diseases;Work

PROJECT_TITLE: Chemical Inhibition PTPN22 to boost anti-viral immunity


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Immunization;Immunotherapy;Infectious Diseases;Nanotechnology;Vaccine Related

PI_NAMEs: KIM, HYUNJOON  (contact)

PROJECT_TERMS: Adjuvant;Animal Model;Antibiotics;Antigens;Attenuated;B-Cell Activation;Bacteria;Biodistribution;Biological Assay;Biology;Caco-2 Cells;Cell Line;Cells;Chemicals;Chronic;Communicable Diseases;cytokine;Dendritic Cells;Disease;Drug Delivery Systems;Drug Kinetics;efficacy validation;Encapsulated;Endothelial Cells;Flow Cytometry;fluorescence imaging;gastrointestinal;Gastrointestinal tract structure;Goals;Healthcare;high throughput screening;high-throughput drug screening;Histologic;Immune;Immunity;Immunoglobulin A;Immunotherapeutic agent;Immunotherapy;in vitro Assay;in vivo;Inflammation;Inflammatory;Intestines;Libraries;liquid chromatography mass spectrometry;Measures;mesenteric lymph node;Methods;Mucosal Immunity;Mutate;nano;nanoparticle;nanoparticle drug;nanoparticulate;nanopolymer;nanotoxicity;novel;Oral;Organ;pathogen;Pathogenesis;Pharmaceutical Preparations;prophylactic;Regimen;Rodent;Route;Safety;screening;Small Intestines;small molecule;Source;standard of care;System;T-Lymphocyte;Therapeutic;TNF gene;uptake;Vaccine Adjuvant;vaccine development;Vaccines;Virus

PROJECT_TITLE: Methods to modulate GI inflammatory and infectious diseases


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Kidney Disease;Organ Transplantation;Pediatric;Precision Medicine;Prevention;Transplantation

ORG_STATE: PA

PHR: PROJECT NARRATIVE To improve pediatric kidney transplant survival, we propose to investigate how non-invasive MRI and contrast- enhanced ultrasound imaging biomarkers may detect and predict allograft injury at-risk of failure. This research is highly relevant to public health as it targets improving long-term health outcomes globally by validating more accessible imaging technology and enhancing personalized management based on individual imaging patterns of kidney transplant dysfunction; imaging as surveillance tool to assess allograft health.

PI_NAMEs: VITERI BAQUERIZO, BERNARDA  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Adult;Advisory Committees;allograft rejection;Allografting;arterial spin labeling;Back;Biological Markers;biomedical imaging;Biopsy;Blood capillaries;Blood flow;Blood Vessels;career;career development;Child;Childhood;Childhood Injury;Chronic;Chronic Kidney Failure;Clinical;Clinical Research;cohort;contrast enhanced;Contrast Media;cost;Data;data acquisition;Data Analyses;Death Rate;design;Deterioration;Development Plans;Diagnosis;diagnosis standard;diagnostic biomarker;Dialysis procedure;Diffusion;Doctor of Philosophy;Early Diagnosis;End stage renal failure;Ensure;Environment;experience;Extravasation;Failure;Fistula;follow-up;Foundations;Freedom;Functional disorder;Future;Glomerular Filtration Rate;Goals;graft failure;Health;Hemorrhage;Hypoxia;Image;Image Enhancement;imaging biomarker;imaging modality;Imaging technology;Immunologics;Immunotherapy;improved;indexing;Individual;Infiltration;Inflammation;Inflammatory;Injury;Intervention;Investigation;kidney allograft;Kidney Diseases;Kidney Transplantation;Leadership;life span;Magnetic Resonance Imaging;Measures;Mentors;Mentorship;Microbubbles;multidisciplinary;Nephrology;Non-Invasive Detection;non-invasive imaging;noninvasive diagnosis;novel;Oncogenic;Operative Surgical Procedures;Outcome;Participant;patient oriented;patient oriented research;Pattern;Pediatric Hospitals;Pennsylvania;Perfusion;personalized management;personalized medicine;Philadelphia;Positioning Attribute;post-transplant;pre-clinical;Process;Prognosis;Prognostic Marker;Public Health;quantitative imaging;rate of change;Renal function;Research;Research Design;Research Personnel;Research Project Grants;research study;Research Training;Risk;Scientist;skills;Statistical Methods;Structure;success;surveillance imaging;Time;tool;Training;Translational Research;Transplant Recipients;Transplantation;treatment planning;Ultrasonography;ultrasound;Universities;vasoconstriction;water diffusion

PROJECT_TITLE: IMPAKT Study: Imaging Modalities in Pediatric Assessments of Kidney Transplants

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK(M1)-1-D]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Microbiome

PI_NAMEs: ANTUNES, LUIS CAETANO MARTHA (contact)

PROJECT_TERMS: Anti-Infective Agents;Bacteria;Biological Assay;Biology;Categories;Chemicals;Cholera;Collection;Communicable Diseases;Communication;Complex;Development;Environment;fecal metabolome;Feces;Food;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;Genome;Goals;gut microbiota;Health;Host resistance;Human;Human body;human pathogen;Immune system;Infection;insight;Mass Spectrum Analysis;Microbe;microbial community;microbiome;microbiota;microbiota metabolites;Modeling;Motility;Nature;Nuclear Magnetic Resonance;pathogen;Pathogenesis;Pathogenicity;Phenotype;Play;Property;Repression;response;Role;Salmonella enterica;Signal Transduction;Signaling Molecule;small molecule;Source;Therapeutic;transcriptome;Vibrio cholerae;Virulence;virulence gene;Work

PROJECT_TITLE: Microbiome-derived small molecules and host resistance against Vibrio cholerae


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Rural Health;Social Determinants of Health

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Bleeding or excessive blood clots are concerns in multiple diseases, injury, and in many other situations that require blood thinners/anticoagulants. It is difficult to manage these conditions in limited-resource settings, especially since current tools to test blood are expensive, cumbersome, and slow. To overcome these drawbacks, we will create a low cost, highly portable, accurate paper-based clotting analysis test (P-CAT) to assess characteristics of blood clotting, while requiring no external power, similar in concept to rapid antigen tests used for COVID-19.

PI_NAMEs: BARK, DAVID  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Anticoagulants;antigen test;Arrhythmia;Biological Assay;Biological Markers;Blood;Blood coagulation;Blood flow;Blood Glucose;Blood Platelets;blood product;Blood specimen;Blood Tests;Blood Transfusion;Capital;Cardiovascular Diseases;Cause of Death;Characteristics;clinically relevant;Coagulation Process;Collagen;combat;Consumption;Coronary Arteriosclerosis;cost;cost effective;COVID-19;Data;Defect;Dependence;Devices;Diagnostic Equipment;Disease;Drops;Drug Costs;Electricity;Environment;Equipment;experimental study;Extracorporeal Membrane Oxygenation;Feedback;Fibrinolytic Agents;Functional dependence;Generations;Goals;Growth;Health;Health Care Costs;health disparity;Hemorrhage;Hemostatic Agents;Hemostatic function;Hospitals;improved;Infection;inhibitor;Injury;innovation;Ischemia;Life;light weight;low and middle-income countries;Medical Device;Microfluidics;Modeling;Monitor;Nature;operation;Operative Surgical Procedures;Outcome;Paper;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;point of care;Point of Care Technology;point-of-care diagnostics;Porosity;portability;prevent;Process;Resource-limited setting;Resources;response;rural area;rural health clinic;Sampling;Secondary to;Sensitivity and Specificity;Severities;skills;Speed;Stenosis;Technology;test strip;Testing;Thromboplastin;Thrombosis;thrombotic;Thrombus;Time;Tissues;tool;Transfusion;Trauma;user-friendly;Warfarin;Work

PROJECT_TITLE: Paper-based high shear hemostatic analytical device

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-D(81)S]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Youth obesity and related disparities are increasingly recognized as a systems problem requiring multi-level, multi-component interventions. Learning from positive deviator schools who show unexpectedly low obesity prev- alence, the proposed study aims to identify factors in food systems that may have contributed to the low preva- lence in these schools and assess the applicability of these factors in other disadvantaged school settings using simulation models. The results of this study will advance our understanding of obesogenic factors in food sys- tems affecting schoolchildren and propose potential changes in food systems to improve diet among youth and mitigate youth obesity disparities.

PI_NAMEs: MATSUZAKI, MIKA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Adolescent;Adult;Affect;Award;Biological;Biological Models;Black American;California;cardiometabolism;Career Mobility;Characteristics;Child;Cities;Collaborations;Communities;Data;Data Sources;design;Development;Diet;Disadvantaged;Disparity;Disparity population;Doctor of Philosophy;Eating;Educational Curriculum;Educational workshop;Effectiveness;Environment;ethnic minority;ethnic minority population;Ethnic Origin;Evaluation;Exercise;experience;experimental study;Exposure to;Food;food environment;Food Supply;Future;Gender;Generations;Geographic Information Systems;Goals;Grant;Health;Human;improved;Individual;insight;Institution;International;Intervention;Interview;Knowledge;large scale simulation;Laws;Learning;Location;Low Prevalence;meetings;Mentored Research Scientist Development Award;Mentors;Methods;Mexican Americans;minority student;Modeling;models and simulation;multi-component intervention;neglect;New York;Not Hispanic or Latino;novel;novel strategies;nutrition;Nutrition Policy;nutritional epidemiology;Obesity;obesogenic;Overweight;Policies;Policy Maker;Population;predictive modeling;Prevalence;prevent;Process;professor;Public Health;Public Health Schools;Race;racial minority;racial minority population;Regulation;Research;Research Training;Review Literature;San Francisco;Scholarship;school district;Schools;Science;Series;service delivery;Services;simulation;skills;social;socioeconomic disadvantage;socioeconomics;Source;Statistical Models;Students;Subgroup;success;supply chain;System;systemic intervention;Techniques;Testing;tool;Training;trend;Universities;Urbanicity;Variant;Youth

PROJECT_TITLE: Systems Science Approaches for Reducing Youth Obesity Disparities


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: SAN ANTONIO

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Oral diseases remain highly prevalent and greatly affect the health of the US population. In addition, there is a well-documented shortage of faculty members in US dental schools and a persistent need for research and improved dental treatments. Therefore, building on our expertise in research training, our goal is to train a cadre of highly skilled scientists who can successfully address the new opportunities in dental, oral, and craniofacial research and serve as future academic faculty in US dental schools.

PI_NAMEs: HARGREAVES, KENNETH M (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TITLE: Craniofacial Oral-biology Student Training in Academic Research (COSTAR)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Systematic tuberculosis (TB) screening is recommended for all HIV-infected individuals living in TB endemic areas to identify individuals without active TB who are eligible for preventive therapy, an intervention proven to reduce both TB incidence and mortality. However, tests to rule-out TB perform poorly in people living with HIV resulting in millions of eligible individuals being denied this life-saving intervention. We plan to perform a clinical trial to determine whether a more accurate and efficient approach to TB screening – screening based on C-reactive protein levels – reduces TB incidence and mortality by increasing uptake of TB preventive therapy in people living with HIV. Because successful scale-up of TB preventive therapy has been projected to prevent hundreds of thousands of new TB diagnoses and save tens of thousands of lives, findings from this trial have the potential to have enormous clinical and public health impact and are essential for informing future TB/HIV policy.

PI_NAMEs: DOWDY, DAVID WESLEY;PHILLIPS, PATRICK PJ;YOON, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: VUGA, LOUIS J

PROJECT_TERMS: Acceleration;Acute-Phase Proteins;Africa;Africa South of the Sahara;antiretroviral therapy;Area;Biological Assay;Biological Testing;Blood capillaries;Blood specimen;C-reactive protein;CD4 Lymphocyte Count;Cells;Characteristics;Clinic;Clinical;Clinical Trials;comparative cost effectiveness;cost;cost comparison;cost effective;cost effective intervention;cost effectiveness;Data;Detection;Diagnosis;Drug resistance in tuberculosis;Economics;effectiveness evaluation;Eligibility Determination;Epidemic;Epidemiology;Fingers;Future;Generations;Grant;HIV;HIV diagnosis;HIV Seropositivity;HIV/AIDS;HIV/TB;improved;improved outcome;Incidence;incremental cost-effectiveness;Individual;Infection;innovation;Interleukin-6;Intervention;Lead;Life;Measures;Mediating;Modeling;mortality;Outcome;Participant;Patient-Focused Outcomes;Peripheral;Persons;point of care;Policies;Population;prevent;Preventive therapy;primary endpoint;primary outcome;Public Health;Randomized;randomized trial;Recommendation;Regimen;Research;Resource-limited setting;Risk;routine practice;scale up;screening;screening guidelines;secondary outcome;Specificity;Symptoms;Testing;therapy outcome;tool;transmission process;trial planning;Tuberculosis;Tuberculosis diagnosis;Uganda;United States National Institutes of Health;uptake;Work;World Health Organization

PROJECT_TITLE: Point-of-care C-reactive protein-based tuberculosis screening in people living with HIV: a randomized trial


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics

ORG_CITY: KANSAS CITY

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

PHR: PROJECT NARRATIVE A gap of knowledge exists in haploid sperm formation with regard to how male germ cells initiate meiotic cell cycle for homologous recombination and reduction of chromosome content. In this project, the investigators will determine the novel role of autophagy, a protein and cellular organelle recycling process, in regulating meiotic initiation. In addition to providing new research directions in studying this process unique to sex cells, the study will offer new approaches for the treatment of male infertility, contraception, and production of haploid sperm cells in culture.

PI_NAMEs: WANG, NING  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Alleles;Autophagocytosis;Binding;Cell Culture Techniques;Cell Cycle;Cell model;Cells;ChIP-seq;Chromosomes;Contraceptive methods;Data;Diploidy;Event;Gatekeeping;Gene Activation;Genes;Genetic;genetic approach;Germ Cells;Haploidy;homologous recombination;In Vitro;in vivo;Individual;inhibition of autophagy;inhibitor;Investigation;Knowledge;lead candidate;Link;LoxP-flanked allele;Lysosomes;Male Contraceptive Agents;male fertility;Male Infertility;Mammals;Mediating;Meiosis;Meiotic Prophase I;men;Mitotic;Molecular;Mus;mutant;new therapeutic target;novel;novel therapeutic intervention;Organelles;overexpression;Pathway interactions;pharmacologic;Phenotype;prevent;Process;Production;promoter;Protein Degradation Induction;Proteins;Proteomics;receptor;Recycling;Reproductive Medicine;Research;Research Personnel;Resistance;Role;small hairpin RNA;sperm cell;Spermatocytes;Spermatogenesis;Spermatogenic Cell;Spermatogonia;System;Techniques;Testing;Time;Transactivation;transcription factor;Translations;Tretinoin;Work;Zinc Fingers

PROJECT_TITLE: Defining the Mechanism of Meiotic Initiation Through Autophagy Pathway

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE A fundamental understanding of how transcription factors control early development events in human is a critical question in basic biology research. This project uses a new large-scale, systematic approach to study the function of these factors. This work is critical to understand basic mechanisms of development and disease as well as provide knowledge that can be directly applied to develop new applications in regenerative medicine.

PI_NAMEs: SHEYNKMAN, GLORIA  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Acceleration;Alternative Splicing;Area;Binding Proteins;Biological;Biology;Cell Differentiation process;Cell Lineage;Chromatin;cofactor;Data;Development;Disease;DNA Binding;Ectopic Expression;embryonic stem cell;engineered stem cells;Event;Exhibits;FOXP1 gene;Gene Activation;gene regulatory network;gene repression;Genes;Goals;Human;induced pluripotent stem cell;Investigation;Knowledge;Length;Libraries;Messenger RNA;Molecular;Pathologic;Pathway interactions;Phenotype;Physiological;Play;programs;Protein Isoforms;Proteins;proteogenomics;Proteome;Proteomics;Regenerative Medicine;Research;Role;screening;self-renewal;Somatic Cell;Specificity;stem cell differentiation;Systems Biology;transcription factor;transdifferentiation;Work

PROJECT_TITLE: Uncovering the functional diversification mechanisms of transcription factor isoforms involved in stem cell differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Obesity;Physical Activity;Prevention;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE: This multisite mechanistic randomized crossover trial in 180 adults with prediabetes will take place in metropolitan Chicago, IL, and Minneapolis/St. Paul, MN. Comparisons will be made between the effects of six weeks of walking (150 min/week) in natural urban greenspaces and urban areas lacking greenspace. The primary outcomes include measures of psychosocial and physiological stress, air pollution exposure, and biological risk markers for diabetes, inflammation, and cardiovascular disease.

PI_NAMEs: HORTON, TERESA H;PEREIRA, MARK A (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Adult;Air Pollution;Anxiety;Area;Attention;Behavioral;Biological;biological adaptation to stress;Biological Markers;Blood Glucose;blood glucose regulation;Blood Pressure;Buffers;built environment;burden of illness;Carbon Black;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;Chicago;climate change;Communities;Cross-Over Trials;Diabetes Mellitus;diabetes prevention program;diabetes risk;Disease;disorder risk;Economics;effectiveness trial;Elements;Enrollment;Environment;environmental stressor;Etiology;Exercise;experimental study;Exposure to;Green space;Health;Health Benefit;health goals;health inequalities;heart rate variability;high risk;Hormonal Change;Hydrocortisone;Hyperglycemia;improved;indexing;Individual;Inflammation;Inflammatory;Infrastructure;innovation;Insulin;Insulin Resistance;Lipids;Location;Measures;Mediating;Mediation;metropolitan;Modeling;Monitor;Moods;Morbidity - disease rate;mortality;multi-site trial;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesogenic;Outcome;Oxidative Stress;Particulate Matter;Pathway interactions;patient engagement;perceived stress;Persons;Physical activity;Physiological;Play;Poaceae;Policies;Pollution;Population;Prediabetes syndrome;Prevalence;prevent;Preventive measure;primary outcome;psychologic;Psychological Stress;psychosocial;Psychosocial Stress;psychosocial stressors;Public Health;Randomized;response;restoration;Risk;Risk Marker;Role;Salivary;Science;Site;social stressor;Stress;stress reduction;Target Populations;Time;Trees;trial comparing;urban area;urban setting;Urbanization;Walking;walking intervention;Water

PROJECT_TITLE: Effects of Walking in Greenspace and the Built Environment in Adults with Prediabetes: A Randomized Crossover Trial

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Alzheimer’s Disease (AD) and AD-related dementias (ADRDs) are among the most devastating and challenging societal health concerns that we face. The studies described in this application will characterize the cognitive decline and temporal and spatial progression of tau-based pathology in a rhesus monkey model of tauopathy using comprehensive cognitive assessments, in vivo PET and MRI imaging, longitudinal plasma and CSF biomarkers of degeneration and inflammation, with postmortem quantitative microscopic analyses. Such studies will improve our understanding of the progression of degenerative processes related to tauopathy and provide a powerful translational platform for testing new therapies designed to prevent or modulate the degenerative cascade of AD and ADRDs.

PI_NAMEs: BAXTER, MARK G;KORDOWER, JEFFREY H;MORRISON, JOHN H (contact)

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: 13 year old;Adult;Affect;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;American;Animals;Autopsy;Behavior;Behavior assessment;behavioral impairment;behavioral study;Bilateral;Biological Markers;Brain;Cognition;Cognitive;cognitive task;cognitive testing;cost;Data;Data Set;Dementia;Dependovirus;design;Development;Disease;Distal;Dose;effective therapy;Emotional;Emotions;entorhinal cortex;experience;Face;Future;Genetic;Goals;Health;hippocampal atrophy;Hippocampus;Human;Image;imaging study;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;Inflammation;Infusion procedures;Injections;Liquid substance;Macaca mulatta;Magnetic Resonance Imaging;Measurement;medial temporal lobe;Memory;memory recognition;Microscopic;Modeling;Monkeys;Nature;neocortical;Nerve Degeneration;Neurofibrillary Tangles;neuroinflammation;neuron loss;neuropathology;neuroprotection;nonhuman primate;novel therapeutics;object recognition;Pathogenesis;Pathologic;Pathology;Patients;Pattern;Phase;Phylogeny;Physiology;Plasma;Positron-Emission Tomography;prevent;Process;programs;Request for Proposals;Rodent;Sampling;Serum;Site;Social Behavior;Structure;Synapses;tau aggregation;tau expression;tau mutation;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic Agents;therapeutic development;therapeutic evaluation;therapy design;Time;Translating;translational model;translational potential;Validation;vector;Viral;Work

PROJECT_TITLE: Tau based Monkey model of Alzheimer's Disease; Structure and Function


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Liver Disease;Nanotechnology

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE This R01 proposal will develop novel nanoformulations of CF10, the first DNA-based fluoropyrimidine (FP) polymer. CF10 displays improved anti-cancer activity relative to standard of care 5-FU in pre-clinical colon cancer models and an improved toxicity profile. Lipid nanoparticle (LNP) formulation and conjugation with polyethylene glycol (PEG) polymers will be implemented to improve CF10’s pharmacological properties. Further, our nanomaterials will be targeted specifically to tumor tissue using a tripeptide motif, RGD, recognized only by malignant cells. We prepare for the first time FP polymers including EdU, a nucleotide analog with complementary cytotoxicity to CF10, and implement the most effective nanoformulation to deliver the most potent FP polymer. Our project will produce a novel nanomaterial with exceptional antitumor activity for clinical development.

PI_NAMEs: GMEINER, WILLIAM H. (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Adjuvant;analog;anticancer activity;Bile fluid;Biodistribution;cancer cell;Cancer Model;Chemistry;Chemotherapy-Oncologic Procedure;clinical candidate;clinical development;clinical translation;Collaborations;Colon;colon cancer patients;Colon Carcinoma;Colorectal;Colorectal Cancer;Combination Drug Therapy;copolymer;cytotoxic;cytotoxicity;Deoxyuridine;design;DNA;Dose;Drug Kinetics;Extrahepatic;fluoropyrimidine;Fluorouracil;Formulation;Generations;Genetically Engineered Mouse;Goals;Half-Life;Hepatic;Immune response;improved;improved outcome;In Vitro;in vivo evaluation;Injections;Integrins;Link;lipid nanoparticle;liquid chromatography mass spectrometry;Liver;Lung;Malignant - descriptor;Metabolism;metastatic colorectal;Metastatic Neoplasm to the Liver;Methodology;Methods;Modeling;Molecular Target;monomer;mouse model;Mus;Nanodelivery;nanoformulation;nanomaterials;nanopolymer;nanoscale;novel;novel strategies;Nucleic Acids;nucleotide analog;overexpression;Peptides;Periodicity;Pharmaceutical Preparations;pharmacologic;Phase;Plasma;Plasma Enhancement;Polyethylene Glycols;Polymers;potency testing;pre-clinical;preclinical study;Prevention;Property;pyrimidine metabolism;Rattus;Recurrence;Recurrent disease;Regimen;Relapse;Resistance;RGD (sequence);Ribonucleotides;Risk;Risk Reduction;scaffold;Single-Stranded DNA;Specificity;standard of care;System;systemic toxicity;Testing;Therapeutic;Thymidine;Thymidylate Synthase;Time;Tissues;Toxic effect;Toxicity Tests;Toxicology;Treatment Failure;tumor;tumor specificity;Tumor Tissue;Vertebral column

PROJECT_TITLE: Nanodelivery of FP polymers to improve treatment of metastatic colorectal cancer


NIH_SPENDING_CATS: Bioengineering;Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative. Post-translational modifications of histone proteins regulates gene expression and dysregulation is associated with a wide range of diseases, making them an important medicinal target. However, many of the fundamental molecular mechanisms are still poorly understood and new chemical tools are needed to advance the field. This proposal develops new approaches to address these challenges and advance biomedical research in the field.

PI_NAMEs: WATERS, MARCEY L (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Mechanistic Investigation and Engineering of Histone Reader Proteins

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Diabetes;Kidney Disease

ORG_CITY: TOLEDO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS

ORG_STATE: OH

PHR: PROJECT NARRATIVE Podocyte dysfunction, due to defective insulin signaling, oxidative stress or accelerated senescence, is a key determinant of progression of diabetic kidney disease, a severe disease that afflicts hundreds of millions of people worldwide and imposes a heavy burden on the treasury and health-care systems with no definitive treatment available yet. Our preliminary data demonstrated that glycogen synthase kinase (GSK)3β is hyperactive in glomerular podocytes in clinical and experimental diabetic kidney disease, correlating with the severity and progression of diabetic kidney injury. We now propose to continue to examine the role of GSK3β in the pathogenesis of diabetic kidney disease in hopes of developing innovative therapies to halt the progression of diabetic kidney disease by targeting GSK3β with the ultimate goal to improve kidney health.

PI_NAMEs: GONG, RUJUN  (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Acceleration;Acute;Adriamycin PFS;Affect;Albuminuria;Animals;Antioxidants;Attenuated;Automobile Driving;CDKN2A gene;Cell Aging;Chemicals;Clinical;clinically relevant;conditional knockout;Consensus;constitutive expression;Data;db/db mouse;diabetic;Diabetic mouse;Diabetic Nephropathy;Disease;Dose;Ectopic Expression;efficacy testing;End stage renal failure;Exposure to;FDA approved;Functional disorder;Gene Delivery;Genetic;Glycogen Synthase Kinase 3;glycogen synthase kinase 3 beta;glycogen synthase kinase 3 beta inhibitor;Glycogen Synthase Kinases;Goals;Health;Healthcare Systems;Histologic;Hyperactivity;Impairment;improved;In Vitro;in vivo;inhibitor;injured;Injury;injury and repair;Injury to Kidney;Innovative Therapy;Insulin;insulin signaling;Kidney;Kidney Diseases;knock-down;Knock-in;Knock-in Mouse;Knock-out;Lithium;Mediator;men;Modeling;Molecular;Mood stabilizers;multitask;Mus;Natural regeneration;Nephrectomy;novel;organ injury;overexpression;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Pathogenesis;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Phase II Clinical Trials;Phosphorylation;Physiological;Play;podocyte;premature;preservation;prevent;Protein Isoforms;Protein-Serine-Threonine Kinases;Regulation;repaired;Reporting;Research;response;Retinoic Acid Receptor;retinoic acid receptor alpha;Role;senescence;Severities;Signal Transduction;small molecule inhibitor;Specificity;Streptozocin;Stress;synergism;Techniques;Testing;therapeutic target;TP53 gene;transcription factor;Transducers;Tretinoin;Type 2 diabetic;type I diabetic;Work

PROJECT_TITLE: Role of GSK3beta in diabetic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: SCORE NARRATIVE The Brigham and Women's Hospital/Harvard Medical School SCORE Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes will address an important knowledge gap in our understanding of how 1) social and metabolic stress exposures that are more common or unique in women result in health problems during and after menopause—bothersome hot flashes, sleep problems, body fat gain, heart disease; and 2) dissect the brain circuity’s response to stress that drives these health changes during and after menopause. Our Brigham/Harvard SCORE will catalyze women’s health and sex/gender difference research and grow the next generation of investigators in this field. Results of our studies will produce a significant public health impact in aging women by understanding the role and mechanisms of stress in producing midlife women’s health outcomes that are linked with cardiovascular disease and dementia.

PI_NAMEs: JOFFE, HADINE  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Age;Aging;aging related;Animal Model;Animals;Basic Science;biological adaptation to stress;Biology;Body fat;Brain;Brain imaging;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;career;Clinical;Clinical Sciences;Cognition;cognitive change;Collaborations;Data;Dementia;dementia risk;Dynorphins;Education;experience;Exposure to;Fellowship;Female;gamma-Aminobutyric Acid;Gender;gender difference;Goals;Gonadal Steroid Hormones;Growth;Health;health difference;Heart Diseases;hormone therapy;Hormone use;Hospitals;Hot flushes;Human;human model;hypothalamic pituitary gonadal axis;Impaired cognition;improved;Infrastructure;innovation;Institution;Interdisciplinary Study;Investigation;KISS1 gene;Knowledge;Leadership;life span;Link;Mediating;medical schools;Medicine;Metabolic;Metabolic stress;Midlife women;neural;neural circuit;neural network;Neurobehavioral Manifestations;Neuroendocrinology;neuroimaging;neuromechanism;Neurons;neuropsychiatric symptom;neuroregulation;Neurosciences;Neurosecretory Systems;next generation;novel;novel therapeutics;nutritional epidemiology;older women;Outcome;Perimenopause;physiologic stressor;Pilot Projects;Policies;poor sleep;Population;Population Sciences;Postmenopause;Predisposition;Pregnancy;Prevention strategy;Process;programs;Psychosocial Stress;Public Health;Quality of life;reproductive epidemiology;reproductive hormone;reproductive senescence;Research;Research Personnel;Resources;response;Rodent;Rodent Model;Role;Science;Scientist;sex;Sex Differences;Site;Sleep;Sleep Disorders;Sleep disturbances;social stress;social stressor;Stress;stressor;symptom treatment;synergism;Translational Research;translational research program;Travel;vasomotor symptoms;Woman;Women's Health;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Contraception/Reproduction;Dementia;Neurosciences;Sleep Research;Women's Health Research

PHR: LEADERSHIP ADMINISTRATIVE CORE NARRATIVE The Leadership Administration Core (LAC) will oversee the scientific agenda and administration of the research Projects, Career Enhancement Core, and Sleep Resource Core of the Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes. The LAC will also ensure engagement of the Brigham/Harvard SCORE with the broader SCORE research consortium. The LAC will support investigators in achieving the translational aims outlined in the respective Projects and Cores. Our overarching goals are to advance our understanding of stress exposures and neural regulation of reproductive aging health outcomes and catalyze the growth of interdisciplinary and translational women’s health and sex-differences research.

PROJECT_TERMS: Aging;Award;Biology;brain health;cardiometabolism;Cardiovascular system;career;Characteristics;Cognitive;Cognitive aging;Collaborations;Communication;Communities;Dementia;dementia risk;Ensure;Environment;Fortification;Fostering;Future;Gender;Goals;Growth;Health;health difference;Hospitals;Infrastructure;innovation;Institution;interdisciplinary collaboration;International;Investigation;Lead;Leadership;medical schools;Medicine;Monitor;neuroregulation;Neurosciences;Outcome;Performance;Perimenopause;Pilot Projects;Policies;policy implication;Predisposition;Productivity;programs;reproductive senescence;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Role;sex as a biological variable;Sex Differences;Site;Sleep;Sleep disturbances;Stress;symposium;synergism;Time;Translating;translational potential;Translational Research;translational therapeutics;Travel;United States National Institutes of Health;vasomotor symptoms;Woman;Women's Health

PROJECT_TITLE: Leadership Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMNR-A]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Women's Health Research

PHR: CAREER ENHANCEMENT CORE NARRATIVE The Brigham/ Harvard Career Enhancement Core (CEC) will train, support and engage the next generation of investigators in sex differences research in stress, sleep, neural regulation, and health outcomes. The CEC will also impact the wider SCORE and national community through Travel Exchange Fellowships and public dissemination of methods and best practices.

PI_NAMEs: REXRODE, KATHRYN M (contact)

PROJECT_TERMS: Address;Affect;Aging;Award;Basic Science;Biology;Body System;Cardiometabolic Disease;Cardiovascular Diseases;career;Career Mobility;Clinical Research;Cognition;Collaborations;Communities;Dementia;Development;Discipline;E-learning;Education;education research;education resources;educational atmosphere;Educational Models;Educational process of instructing;Elements;Evaluation;Faculty;Fellowship;Fostering;Funding;Future;Gender;Goals;Grant;Growth;Health;health difference;Hospitals;Impaired cognition;Infrastructure;innovation;Institution;Interdisciplinary Study;investigator training;Knowledge;Leadership;Learning;Measurement;medical schools;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Methods;Mission;neuromechanism;neuroregulation;Neurosciences;next generation;Outcome;Participant;Pilot Projects;Population Research;Postmenopause;Predisposition;programs;Publications;Reproducibility;reproductive senescence;Research;Research Infrastructure;Research Methodology;Research Personnel;Resources;Role;Science;sex;sex as a biological variable;Sex Differences;Site;skill acquisition;skills;Sleep;Stress;Structure;Training;Training Programs;Travel;United States National Institutes of Health;Visit;webinar;Woman;Women's Health;Work

PROJECT_TITLE: Career Enhancement Core


ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative: This NCBIB will develop, translate, and disseminate novel noninvasive metabolic imaging technologies to enhance biomedical research, diagnosis, and management in the areas of oncology, cardiovascular disease, neuropsychiatry, and musculoskeletal disorders. These technologies will have substantial impact on the fundamental understanding of disease mechanisms, early diagnosis, and development of novel therapies for several diseases such as Alzheimer’s disease, Epilepsy, Arthritis, Cancer, Stroke, and heart disease, and thus contribute to precision medicine and enhanced patient care.

PI_NAMEs: REDDY, RAVINDER  (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Advanced Development;Advisory Committees;Alzheimer's Disease;Area;Arthritis;Basic Science;bench to bedside;Biological;Biological Markers;Biomedical Engineering;biomedical imaging;Biomedical Research;biomedical resource;Brain;Cardiovascular Diseases;Cardiovascular system;Chemicals;Clinical;clinical care;Clinical Investigator;Clinical Management;Clinical Research;Collaborations;Country;Data;data analysis pipeline;Data Set;Dedications;design;Development;Diagnosis;diffuse optical spectroscopy and imaging;Disease;Early Diagnosis;Educational workshop;Engineering;Ensure;Environment;Epilepsy;experience;Extramural Activities;Faculty;Fostering;Funding;Genetic;Geography;Goals;Health;Healthcare;Heart;Heart Diseases;Housing;Human;Image;imaging biomarker;Imaging Device;Imaging technology;Individual;innovation;Institution;instrument;Intervention;Lesion;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Measurement;Measures;Medical Imaging;Medicine;Metabolic;metabolic imaging;Metabolism;Molecular;Monitor;Muscle;Musculoskeletal;Musculoskeletal Diseases;neuropsychiatry;new technology;next generation;novel;novel strategies;novel therapeutics;Oncology;optical imaging;Oxygen Consumption;Patient Care;patient stratification;Peer Review;Pennsylvania;personalized approach;personalized diagnostics;personalized medicine;personalized strategies;Physiologic pulse;Physiological;Physiology;Placenta;Population;Postdoctoral Fellow;precision medicine;program dissemination;Property;Protocols documentation;Publications;Records;Reproducibility;Research;Research Institute;Research Personnel;Resources;Sampling;Scientist;Services;Skeletal Muscle;Spectrum Analysis;Stroke;Students;technological innovation;Technology;technology development;technology research and development;technology validation;Therapeutic;Therapeutic Intervention;Tissues;tool;Training;training opportunity;Training Programs;Translating;Translations;tumor;Universities;Validation;Visit;visiting scholar;web site

PROJECT_TITLE: Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)


PROJECT_TERMS: Advisory Committees;Animal Experiments;animal imaging;Animals;Businesses;Clinical;Collaborations;Dedications;Doctor of Philosophy;experience;experimental study;Goals;Grant;Human;Human Resources;imaging facilities;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;medical schools;meetings;member;metabolic imaging;National Institute of Biomedical Imaging and Bioengineering;operation;Pennsylvania;precision medicine;Principal Investigator;programs;Protocols documentation;Radiology Specialty;Reporting;Running;Safety;Scanning;Scientist;Services;Spectrum Analysis;Technology Transfer;Time;Training;Universities;Vision;Work

PROJECT_TITLE: Administrative Core-CAMIPM


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Neurosciences;Sleep Research;Women's Health Research

PHR: SLEEP RESOURCE CORE NARRATIVE The Sleep Resource Core (SRC) will be integrated into this SCORE by providing equipment, analysis, sleep- related expertise, and sleep data to the two human, one animal, and relevant Career Enhancement Core projects. The scientific leadership and technical support to facilitate and integrate rigorous collection, processing, analysis, and interpretation of sleep measures, will enable the SRC to promote interdisciplinary, collaborative, synergistic, and translational work and support the scientific and career enhancement goals of this SCORE. This work will expand the scientific impact of the SCORE by including sleep as a key health measure in human and animal models of women’s health and aging, including impacts on response to stress; body composition; neurological, cardiovascular, reproductive, and metabolic function; cognition; and mental health.

PI_NAMEs: KLERMAN, ELIZABETH B. (contact)

PROJECT_TERMS: actigraphy;Address;Affect;Age;Aging;Algorithms;Animal Experimentation;Animal Model;Animals;Area;Body Composition;Calibration;cardiometabolism;Cardiovascular system;career;Certification;Cognition;Cognitive;Collaborations;Collection;Communities;Data;Data Analyses;data cleaning;Data Collection;data de-identification;data integration;Databases;Dementia;demographics;Deposition;Devices;diaries;Disease;Disease Outcome;Education;Electroencephalography;Ensure;Equipment;experience;experimental study;Funding;Goals;Health;health difference;Hospitals;Hot flushes;Human;human model;Implanted Electrodes;indexing;Information Dissemination;innovation;inter-individual variation;Leadership;Link;Maintenance;Manuals;Manuscripts;Measurement;Measures;Mediating;medical schools;Mental Health;Metabolic;Modality;Monitor;Mus;Neurologic;neuroregulation;novel;Operative Surgical Procedures;Outcome;Outcome Measure;Participant;Performance;Perimenopause;Physiological;Physiology;Pilot Projects;Polysomnography;poor sleep;Postmenopause;Predisposition;Preparation;Prevalence;Process;programs;Protocols documentation;Quality Control;Questionnaires;Reading;reproductive;reproductive senescence;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Rest;Risk Factors;Rodent;Science;Secure;Sex Differences;Signal Transduction;Sleep;Sleep disturbances;sleep health;sleep onset;sleep quality;Sleeplessness;Stress;Symptoms;Syndrome;Teacher Professional Development;Techniques;Time;tool;Training;United States National Institutes of Health;Variant;Vasomotor;vasomotor symptoms;web site;Woman;Women's Health;Work;Wrist

PROJECT_TITLE: Sleep Resource Core


NIH_SPENDING_CATS: Cancer;Diabetes;Digestive Diseases;Nutrition;Obesity;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Novel strategies to treat pancreatic ductal cancer (PDA) are urgently needed due to its very poor prognosis. Branched chain amino acids (BCAAs) are avidly consumed by the normal pancreas, and circulating BCAA levels are elevated in both PDA and obesity, a strong risk factor for PDA. We propose here that BCAAs contribute to PDA in two keys ways, first by directly promoting tumor initiation, and next by promoting a systemic environment highly supportive of PDA growth, and will test these hypotheses with a range of mouse models and comprehensive studies on the roles of BCAAs in PDA.

PI_NAMEs: ARANY, ZOLTAN P;WELLEN, KATHRYN ELAINE (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acinar Cell;Allografting;amino acid metabolism;ATP Citrate (pro-S)-Lyase;Biological Markers;Branched-Chain Amino Acids;cancer type;Catabolism;Cell Proliferation;Cell Survival;Cells;chemotherapy;Cholesterol;Citrates;Citric Acid Cycle;Clinical;Clinical Trials;Consumption;curative treatments;Cytoplasm;Dairy Products;Data;Development;Diabetes Mellitus;Diagnosis;Diet;dietary;Disease;Duct (organ) structure;Environment;Epigenetic Process;Evaluation;Fatty acid glycerol esters;Fatty Acids;Feedback;Fibroblasts;gain of function;Genetic;Genetic Models;Goals;Grant;Growth;Growth Factor;Histones;Human;Hyperinsulinism;improved;In Vitro;in vivo;Incidence;inhibitor;insight;Insulin;Insulin Resistance;insulin secretion;insulin signaling;Islets of Langerhans;Isotopes;KRAS2 gene;KRASG12D;Link;Location;loss of function;Malignant neoplasm of pancreas;Malignant Neoplasms;Meat Products;Mediating;Metabolic;Metabolism;Metaplasia;Mitochondria;mouse model;Mus;mutant;novel;novel strategies;novel therapeutic intervention;Nuclear;nutrition;Nutritional;obese person;Obesity;Pancreas;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic tumorigenesis;Patients;pharmacologic;Plasma;Play;Prognosis;response;Risk;Risk Factors;Role;Signal Transduction;Source;standard of care;Survival Rate;Testing;Tracer;treatment response;tumor;tumor growth;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Unresectable;Work;wound healing;young adult

PROJECT_TITLE: Branched chain amino acids and pancreatic cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Cannabinoid Research;Endocannabinoid System Research;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Retinol-binding protein 2 (RBP2) is found solely in the adult intestine and its role in dietary vitamin A uptake and metabolism by absorptive cells is well studied. However, in the previous grant period, we established that RBP2 is also expressed in non-absorptive cells in the gut, including in incretin hormone-secreting enteroendocrine cells and in the colon. We are proposing studies aimed at identifying the actions of RBP2 in the synthesis and secretion of incretin hormones in the small intestine and in the colon.

PI_NAMEs: BLANER, WILLIAM S (contact);GOLCZAK, MARCIN BERNARD;PAIK, JISUN

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: 2-arachidonylglycerol;Adipose tissue;Adult;Affect;Affinity;aldehyde dehydrogenases;All-Trans-Retinol;anandamide;Animal Model;Binding;Binding Proteins;Biochemical;Biology;Body Weight;Cell Differentiation process;cell growth;Cell Physiology;Cell Proliferation;Cell surface;cell type;Cells;Cellular biology;Chromatin;CNR1 gene;CNR2 gene;cognitive function;Colon;Complex;Desire for food;Development;Diet;dietary;Endocannabinoids;Energy Metabolism;Enteroendocrine Cell;Enzymes;Fasting;Fatty acid glycerol esters;G-Protein-Coupled Receptors;gastric inhibitory polypeptide receptor;Genes;Genetic Transcription;glucagon-like peptide 1;Glucose;glucose metabolism;Glycerol;Goals;GPR119 receptor;Grant;Hepatic;High Fat Diet;hormone regulation;Hormone secretion;human model;Hydrolase;Immune response;Impairment;In Vitro;in vivo;incretin hormone;Inflammation;interest;Intestines;Killer Cells;Knockout Mice;L Cells;Ligands;Link;lipid metabolism;lipoprotein lipase;Maintenance;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Methodology;Molecular Weight;Monoacylglycerol Lipases;Monoglycerides;mood regulation;Motivation;Mus;Nerve Degeneration;neurogenesis;Nociception;Nuclear Hormone Receptors;Nutrient availability;Oral;Organoids;oxidation;Pathway interactions;Phenotype;Physiological;prevent;Proliferating;Proteins;Publishing;RBP4 gene;Reporting;response;Retinaldehyde;Retinoic Acid Binding;Retinoic Acid Receptor;retinoic acid receptor alpha;retinoic acid receptor gamma;Retinoic Acid Response Element;Retinoids;Retinol Binding Proteins;Rewards;Role;Secretory Vesicles;Signal Pathway;Signal Transduction;Small Intestines;Smooth Muscle;Tretinoin;Triglycerides;uptake;Vitamin A;Weight Gain;Wild Type Mouse;Work

PROJECT_TITLE: RBP2 Biology and Pathobiology

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Machine Learning and Artificial Intelligence;Neurosciences;Precision Medicine

PROJECT_TERMS: 3-Dimensional;absorption;Address;Alzheimer's disease model;Animal Model;Biological Markers;biomedical scientist;Blood;Brain;Brain imaging;brain tissue;Breathing;Cardiac;Central Nervous System Diseases;Chemical Models;Chemicals;Clinical;clinical translation;Collaborations;commercialization;Consumption;Country;Creatine;data analysis pipeline;data exchange;deep learning;Dependence;Development;Diagnosis;Disease;Disease Progression;Doctor of Philosophy;Early Diagnosis;Epilepsy;Exercise;Glutamates;Goals;healthy volunteer;Heart;heart motion;high resolution imaging;Human;Human Activities;human subject;Image;Imaging Techniques;improved;in vivo;Institution;Kinetics;learning strategy;Machine Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;Mediating;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;Methods;Mitochondrial Diseases;Modeling;Molecular;molecular imaging;Monitor;Myocardium;myoinositol;neurochemistry;Neurotransmitters;new technology;next generation;novel;novel therapeutics;Oxidative Phosphorylation;Parkinson Disease;Pathogenesis;Patient Care;Patients;Physicians;Play;Positron-Emission Tomography;precision medicine;Process;Protons;radio frequency;Radioisotopes;Recovery;Research Personnel;Resolution;Sampling;Scanning;Scheme;Schizophrenia;Scientist;Services;Signal Transduction;simulation;Skeletal Muscle;Slice;spatiotemporal;Specificity;System;Techniques;Technology;Testing;therapeutic development;therapeutic evaluation;Time;Training;Translations;Treatment Efficacy;treatment response

PROJECT_TITLE: Chemical Exchange Weighted Molecular MRI: Technical Development and Clinical Translation


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Menopause;Mental Health;Neurosciences;Sleep Research;Women's Health Research

PHR: NARRATIVE Hot flashes and night sweats, or vasomotor symptoms (VMS), affect up to 85% of postmenopausal women, persist 10 or more years in 33–40% of postmenopausal women, and are strongly liked with stress, which exerts its effects through the brain. Understanding biological mechanisms underlying VMS occurrence and persistence will have significant public health impact because VMS affect so many women, have a negative impact on quality of life, and are associated with sleep disruption and cardiometabolic disease, which increase susceptibility to dementia in aging women. As part of the Brigham/Harvard Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes, this study will advance the health of postmenopausal women by determining stress responses, neural processes, and neurobiological mechanisms that are affected when VMS occur and persist.

PROJECT_TERMS: Acute;acute stress;Adrenal Cortex Hormones;Affect;Aging;Anterior;Anxiety;Autonomic nervous system;Behavior Therapy;Biological;biological adaptation to stress;Brain;Brain region;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;career;Chronic stress;cingulate cortex;cohort;common symptom;comorbidity;Data;Dementia;Dynorphins;Educational process of instructing;Exhibits;Faculty;follow-up;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Health;High Prevalence;Hippocampus;hormone therapy;Hot flushes;hypothalamic-pituitary-adrenal axis;improved;improvement on sleep;innovation;Institution;Insula of Reil;Intervention;Investigation;KISS1 gene;Link;Magnetic Resonance Spectroscopy;Measures;Mediating;Mental Depression;Mentors;Metabolic Diseases;Methodology;neural;neural network;neurobiological mechanism;Neurons;Neurophysiology - biologic function;neuroregulation;Neurotransmitters;Night Sweating;novel;Outcome;Pain;participant enrollment;Pathway interactions;perceived stress;Play;Postmenopause;predicting response;Predisposition;Prevention;Process;Psychosocial Stress;Public Health;Quality of life;reproductive senescence;Resources;response;Risk;Role;Sleep;Sleep disturbances;Stress;Symptoms;targeted treatment;Testing;vasomotor symptoms;Woman

PROJECT_TITLE: Stress response and neural network function in women with vasomotor symptoms


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Exposure to interpersonal violence (IPV) is associated with long-term negative mental health consequences, including an increased risk for posttraumatic stress disorder (PTSD), especially in women. Our previous studies examining the impact and timing of IPV experienced during specific developmental windows revealed increased psychophysiological reactivity and a unique EV protein signature belonging to a 17q21 gene cluster and associated with skin keratinocytes, specific to Merkel cells and only found when IPV was experienced between 14-18 yrs. Our overarching hypothesis to be examined here is that tactile-based IPV trauma exposure during late adolescence increases the sensitivity of threat circuitry, and we propose a cross-species translational study to examine molecular and physiological analyses of the RDoC Acute Threat construct.

PI_NAMEs: BALE, TRACY L (contact);JOVANOVIC, TANJA

PROGRAM_OFFICER_NAME: BORJA, SUSAN EILEEN

PROJECT_TERMS: 17q21;Acute;Adolescence;Adolescent;Adult;Adult women;Age;age group;Behavior;Biological;Biological Markers;biomarker identification;Birth;black men;Black race;black women;Brain;Cations;Characteristics;Childhood;Chronic;cohort;Collection;Complex;conditioned fear;Data;designer receptors exclusively activated by designer drugs;Development;Discrimination;Disease Outcome;disorder risk;emotional abuse;experience;Exposure to;extracellular vesicles;Freezing;Fright;Galvanic Skin Response;Gene Cluster;Health;Human;Individual;insight;Interpersonal Violence;Intervention;Keratin;keratinocyte;life span;Light;Link;Longitudinal cohort;Measures;men;Mental Health;Merkel Cells;Molecular;mouse model;multimodality;Mus;nanoparticle;Neurites;Neuroendocrine Cell;Neurons;neurophysiology;novel;novel marker;Outcome;Pathway interactions;Physiological;Piezo 2 ion channel;Play;Population;Post-Traumatic Stress Disorders;potential biomarker;Production;programs;prospective;Proteins;Proteomics;Psychophysiology;Puberty;Reporting;Research Domain Criteria;Resources;response;RiboTag;Risk;Role;Sensory;Sensory Thresholds;Skin;specific biomarkers;Startle Reaction;Stimulus;Stress;Tactile;tactile stimulation;Testing;Tissues;Touch sensation;transcriptomics;translational study;Trauma;trauma exposure;violence exposure;Woman;Women's study;young adult;zeta potential

PROJECT_TITLE: Extracellular vesicles as biomarkers of trauma exposure and PTSD risk


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Contraception/Reproduction;Dementia;Depression;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Maternal Health;Maternal Morbidity and Mortality;Menopause;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Obesity;Pregnancy;Prevention;Sleep Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

PHR: NARRATIVE During perimenopause, women experience dramatic changes that extend beyond cessation of menses, including alterations that accelerate the aging process and elevate risks for cardiometabolic diseases cognitive impairment, and dementia as well as Alzheimer’s disease. This Project will investigate physiological and social stressors in early life and around the time of pregnancy as predictors of body composition, neuropsychiatric symptoms, and sleep duration and quality in mid-life. Results from the proposed series of investigations have the potential to influence clinical care of aging women through informing both guidelines on screening and long- term follow-up from the reproductive years into menopause and research priorities related to cardiometabolic diseases and dementia risk profiles in women.

PI_NAMEs: OKEN, EMILY  (contact)

PROJECT_TERMS: actigraphy;Address;Adipose tissue;Adult;adverse childhood events;Affect;Age;age acceleration;Aging;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Anxiety;Attention;Behavior;Behavioral;Blood Pressure;blood pressure elevation;Body Composition;Body System;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Cerebrovascular Disorders;Cholesterol;clinical care;cognitive function;cohort;Data;Dementia;dementia risk;depressive symptoms;Development;diaries;Disease;disorder risk;early pregnancy;Electronics;Environmental Risk Factor;experience;Exposure to;Fasting;follow-up;Future;Genetic;Gestational Diabetes;gestational weight gain;Glucose;Goals;Guidelines;Health;Hour;Hypertension;Impaired cognition;Insulin;interest;Investigation;Life;Lipids;Longitudinal Studies;Longterm Follow-up;Measures;Mediating;Memory;men;Menopause;Menstruation;Mental Depression;Metabolic;Methods;middle age;Neurobehavioral Manifestations;neuropsychiatric symptom;neuropsychiatry;neuroregulation;Non-Insulin-Dependent Diabetes Mellitus;Obesity;OGTT;Outcome;Outcome Assessment;Perimenopause;Perinatal;physiologic stressor;poor health outcome;poor sleep;Postmenopause;postpartum weight;Pregnancy;pregnancy disorder;Premenopause;prospective;Quality of life;Questionnaires;racism;recruit;reproductive;reproductive senescence;Research Priority;Resources;Risk;Risk Factors;Roentgen Rays;screening;Series;sex;Sleep;Sleep disturbances;social;social stressor;Statistical Data Interpretation;Stress;study population;synergism;Testing;Time;vascular cognitive impairment and dementia;Vasomotor;vasomotor symptoms;Violence;Visceral;waist circumference;Weight;Weight Gain;Woman;Women's cohort;Work;Wrist

PROJECT_TITLE: Physiologic and social stressors and health during menopausal transition


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: HERSHEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative  Translesion DNA synthesis, the predominant DNA damage tolerance pathway in humans, promotes cell survival in the face of DNA damage by allowing replication of a damaged genome to continue. Tight regulation of translesion DNA synthesis is critical as dysfunction can selectively propagate cells with increased mutagenesis or gross chromosomal rearrangements, which can lead to cancer. This research proposal seeks a fundamental, molecular understanding of human translesion DNA synthesis to identify dysfunctions that promote disease.

PI_NAMEs: HEDGLIN, MARK  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: Acute;Area;Biochemistry;Biological;Biophysics;cancer cell;Cancer Etiology;cancer therapy;carcinogenesis;Cell Death;Cell Survival;Cells;chemotherapy;Chromosomal Rearrangement;Closure by clamp;Code;Complex;Critical Pathways;design;Disease;DNA biosynthesis;DNA Damage;DNA Repair;DNA Replication Damage;DNA Replication Factor;DNA-Directed DNA Polymerase;Environment;Event;Exposure to;Fibroblast Growth Factor;Functional disorder;Genetic;Genome;Goals;Health;Human;Human Activities;human DNA damage;Human Genome;interest;Kinetics;Knowledge;Link;Malignant Neoplasms;Modification;Molecular;Molecular Biology;Monoubiquitination;Mutagenesis;Pathway interactions;programs;Property;recruit;Regulation;Research;Research Proposals;Site;Slide;Techniques

PROJECT_TITLE: Deciphering the progression and regulation of human translesion DNA synthesis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: PROJECT NARRATIVE This study proposes the novel use of a bedrail-affixed technology-based patient hand hygiene system with verbal and visual reminders to improve hospitalized older adults’ self-management of their hand hygiene practice, which in return reduces harmful germs found on hands that lead to infections.

PI_NAMEs: KNIGHTON, SHANINA C (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Acute;acute care;Address;Admission activity;Adult;Advocacy;Age;age-related disease;Auditory;Beds;Behavior;Biomedical Engineering;Biometry;Cessation of life;Clinical;Cognitive;Collaborations;Colony-forming units;Communicable Diseases;Communities;cost;Cost Analysis;cost effectiveness;Dependence;dexterity;disability;Disease;Disease Outbreaks;Elderly;Elements;Enhancement Technology;Environment;Equipment;Equity;Ethnic Origin;experience;Failure;fall risk;frailty;Friends;Germ;Goals;Group Hospitalization;Hand;Hand functions;Health;health disparity;Healthcare;healthcare-associated infections;high risk;Hospitalization;Hospitals;human old age (65+);Hygiene;implementation evaluation;implementation outcomes;implementation science;improved;Infection;Infection Control;Infection prevention;infection rate;infection risk;Inpatients;Institution;Intervention;Long-Term Care;manufacture;Measures;Mechanics;Medical Device;Methods;microbial;Motion;Motivation;multi-drug resistant pathogen;new technology;novel;Nurses;older adult;Outcome;Participant;pathogen;patient engagement;patient oriented;Patients;Perception;Personal Satisfaction;Physical Efforts;pilot test;Policies;prevent;Prevention;primary outcome;Process;Public Hospitals;Quality of Care;Race;Randomized;Randomized, Controlled Trials;Reduce health disparities;Research;Research Personnel;Risk;Safety;Scientist;Self Management;Sensory;Sepsis;Strategic Planning;Surface;System;Technology;Testing;Time;Touch sensation;Training;translational potential;transmission process;treatment as usual;trial comparing;United States National Institutes of Health;Update;Upper Extremity;user-friendly;verbal;Visual;Work

PROJECT_TITLE: Clean Hands Accessible and Manageable for Patients (CHAMPs): A technology-based self-management intervention to improve patient hand hygiene and reduce hand contamination among older adults.

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Estrogen;Menopause;Neurosciences;Sleep Research;Women's Health Research

PHR: NARRATIVE Reproductive aging in women (i.e., menopause) leads to a number of distressing physiological alterations associated with the decrease in circulating estrogens, among which vasomotor symptoms (also referred to as hot flashes) significantly disrupt sleep and disturb quality of life and may be relevant to subsequent risk of adverse health outcomes such as cardiovascular disease and dementia. Stress can affect the severity of vasomotor symptoms; however, the mechanisms underlying the control of thermoregulation by sex steroids and how this can be modulated by stress remain unknown. We aim to address this knowledge gap by using a series of genetic, behavioral and pharmacological approaches to identify the neuronal circuitry connecting the reproductive axis, stress, thermoregulation, and sleep quality.

PI_NAMEs: KAISER, URSULA B. (contact)

PROJECT_TERMS: Ablation;Address;Adrenal Cortex Hormones;Adverse effects;adverse outcome;Affect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Behavioral;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;Cells;Dementia;Development;Disease susceptibility;disorder risk;Distress;Dynorphin A;Dynorphins;Estradiol;Estrogens;experience;Female;GABA Receptor;gamma-Aminobutyric Acid;Genetic;Glucocorticoid Receptor;Glucocorticoids;Goals;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Health;High temperature of physical object;Hormone secretion;Hormones;Hot flushes;hypercortisolemia;hypothalamic pituitary gonadal axis;Hypothalamic structure;Impairment;improved;insight;KISS1 gene;Knowledge;Link;Malignant Neoplasms;Mediating;Mediator;Menopausal Symptom;Menopause;Modeling;mouse genetics;mouse model;Mus;neural circuit;Neurokinin B;neuronal circuitry;Neurons;Neuropeptides;neuroregulation;novel strategies;Obesity;Outcome;Ovariectomy;Pathway interactions;Patients;Peripheral;pharmacologic;Physiologic Thermoregulation;Physiological;Play;Predisposition;Quality of life;Regulation;Reproduction;reproductive axis;reproductive function;Reproductive Health;reproductive senescence;restraint stress;Risk;Role;Series;Severities;Sleep;Sleep disturbances;sleep pattern;sleep quality;Stress;stress symptom;stressor;Structure of nucleus infundibularis hypothalami;Sweating;Tachykinin;Testing;Time;tool;Vasodilation;vasomotor symptoms;Woman;women's outcomes;Work

PROJECT_TITLE: Deciphering the interactions of stress, corticosteroids, and Kiss1 neurons in reproduction and vasomotor symptoms in aging females


ADMINISTERING_IC: TR

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative

PI_NAMEs: LEE, DEXTER L;SANDBERG, KATHRYN L (contact)

PROGRAM_OFFICER_NAME: BOUGH, KRISTOPHER J

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Acceleration;Active Learning;Aging;Animals;Basic Science;Bioethics;Biomedical Research;career;career development;Clinical;Clinical and Translational Science Awards;clinical application;clinical center;Clinical Research;Clinical Sciences;Clip;college;community engagement;cost effective treatment;Cultural Sensitivity;Development Plans;didactic education;Discipline;Disease;District of Columbia;doctoral student;drug discovery;Drug Formulations;drug synthesis;Drug Targeting;Education;Educational process of instructing;Educational Status;Educational workshop;experience;Faculty;Foundations;Future;Goals;Grant;Health;Healthcare;Human;improved outcome;Individual;Industry;Inosine Diphosphate;Institution;Laboratories;Leadership;Link;Marketing;Medical center;Medicine;Mentors;Mentorship;Minority-Serving Institution;National Research Service Awards;Neurosciences;novel;Pharmaceutical Preparations;Phase;Phase II Clinical Trials;Positioning Attribute;Postdoctoral Fellow;pre-clinical research;pre-doctoral;Principal Investigator;programs;Reporting;Research;research and development;Research Institute;Safety;scale up;Science;Scientist;skills;therapeutic target;Toxicity Tests;Training;Training Programs;translational goal;Translational Research;translational scientist;Translations;United States Department of Veterans Affairs;Universities;Washington;Work;Workforce Development

PROJECT_TITLE: Translational Biomedical Science Training Grant


ORG_CITY: PHILADELPHIA

PI_NAMEs: WEHRLI, FELIX W (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Blood;Blood flow;blood fractionation;blood oxygen level dependent;Blood Vessels;Body System;Brain;Breathing;Calibration;Carrying Capacities;Categories;Cells;Cerebrum;Clinic;Clinical;Clinical Medicine;Consumption;Coupling;Data;Degenerative Disorder;Development;Diagnosis;Disease;Doctor of Philosophy;Equation;Erythrocytes;Evaluation;extracellular;falls;Fetus;Gases;Heme Iron;Hemoglobin;Human;Hypercapnia;Hyperoxia;imaging modality;Imaging technology;in utero;in vivo;Information Dissemination;Institution;interest;Intervention;Knowledge;Laboratories;Life Style;magnetic field;Magnetic Resonance Imaging;Magnetism;Maps;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;metabolic imaging;metabolic rate;Metabolism;Methods;milliliter;Modeling;Mole the mammal;neural stimulation;new technology;Optics;Organ;Oxygen;Oxygen Consumption;Oxygen saturation measurement;Patients;Performance;Physiological;Placenta;precision medicine;Predisposition;Preparation;Protocols documentation;Publishing;Quantitative Evaluations;Relaxation;Reproducibility;Research Personnel;response;Response to stimulus physiology;signal processing;Signal Transduction;Standardization;Techniques;Technology;technology development;temporal measurement;Testing;Time;Tissues;Translating;Translations;treatment response;Validation;Water;water diffusion;Work

PROJECT_TITLE: High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in Humans


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioids;Substance Misuse

PHR: NARRATIVE The dorsal endopiriform nucleus (DEn) is a long, thin subcortical brain region that is highly connected with the limbic circuit and considered by some to be the limbic component of the claustrum, however its function remains largely unknown. We have found a non-dopaminergic projection from the ventral tegmental area (VTA) to the DEn that is strongly inhibited by mu opioid receptor activation. Here we propose to anatomically and functionally characterize the neural connection from the VTA to the DEn and investigate the contribution of this connection to behavior.

PI_NAMEs: MARGOLIS, ELYSSA  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acceleration;Agonist;Alcohol consumption;Anatomy;Animals;Attention;Behavior;Brain;Brain region;Cell Nucleus;Cerebral cortex;Claustral structure;Conscious;Cues;delta opioid receptor;design;Development;Disease;Dopamine;Dorsal;endogenous opioids;experimental study;food consumption;G-Protein-Coupled Receptors;Generations;Genetic;Health;Investigation;kappa opioid receptors;Label;Learning;Light;Link;Maps;Medial;Messenger RNA;Modality;motivated behavior;Motivation;mu opioid receptors;nerve supply;neural;neurochemistry;Neurons;neurotransmitter release;Neurotransmitters;Nucleus Accumbens;Opioid;Opioid Peptide;Opioid Receptor;Optics;Outcome;Output;Performance;Phenotype;Play;postsynaptic;preference;Prefrontal Cortex;Prosencephalon;Proteins;Psychological reinforcement;Receptor Activation;receptor expression;receptor function;Resolution;response;Rewards;Role;Seizures;Sensory;sensory cortex;sensory input;sensory integration;Signal Transduction;Site;Stress;Structure;Synapses;Techniques;Testing;Thinness;Time;tool;Tracer;Ventral Tegmental Area;Viral Vector;Whole-Cell Recordings

PROJECT_TITLE: A highly opioid responsive VTA projection to the dorsal endopiriform nucleus.

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Asthma;Biotechnology;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Genetics;Human Genome;Lung;Pediatric

PHR: Project Narrative Increasing molecular evidence suggests a lifelong trajectory of lung impairment from prenatal lung development to asthma in childhood to chronic obstructive pulmonary disease (COPD) in adulthood. Multi-omics data collected over time across well-characterized cohorts hold the potential to understand this complex disease progression. Here, we propose to apply network-based computational methods that will integrate and jointly analyze genetic, epigenetic and transcriptomic data to better understand the temporal progression from fetal lung development to childhood asthma, and to determine the key molecules mediating between asthma and COPD.

PI_NAMEs: HALU, ARDA  (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Address;Adult;Advisory Committees;airway obstruction;Algorithms;Area;Asthma;asthmatic;Award;Big Data;Bioinformatics;Biological;Biology;Blood;Blood specimen;Catalogs;CD4 Positive T Lymphocytes;Childhood;Childhood Asthma;chronic airflow obstruction;Chronic Obstructive Pulmonary Disease;clinical translation;cohort;Complex;Computing Methodologies;computing resources;Confidence Intervals;Data;Development;Disease;disease model;Disease Progression;DNA Methylation;Educational workshop;Environment;Epidemiology;Epigenetic Process;epigenetic regulation;epigenomics;Etiology;Fetal Lung;fetal smoke exposure;Gene Expression;Genes;Genetic;Genetic Risk;Genetic Transcription;Genome;Genomics;high risk;human data;Impairment;improved;in utero;insight;Life;Link;Lung;lung development;Lung Diseases;Mediating;Mediator;Medical Informatics;medical schools;Medicine;meetings;member;Mentors;Messenger RNA;Methodology;Methods;Methylation;MicroRNAs;Modeling;Molecular;Multiomic Data;Network-based;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Phenotype;Physics;Population;precision medicine;Predisposition;prenatal;Proteome;Public Health;Research;risk variant;Sampling;Signal Transduction;Site;skills;Smoke;SNP genotyping;Standardization;Structure of parenchyma of lung;System;Systems Biology;Teaching Hospitals;Testing;Time;Tissue Microarray;Tissues;Training;Training Programs;Transcription Process;transcriptomics;Whole Blood

PROJECT_TITLE: Integrative network-based analysis of multi-omics data to elucidate the molecular connection between asthma and COPD

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


NIH_SPENDING_CATS: Diabetes

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: We are training the next generation of scientists with expertise in diabetes, metabolic, and endocrine diseases. These trainees will make discoveries during and after their training that will improve our understanding of and lead to new and improved treatment for these conditions.

PI_NAMEs: NISWENDER, KEVIN D (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Research Training in Diabetes and Endocrinology

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Biotechnology;Neurodegenerative;Neurosciences;Precision Medicine;Rare Diseases

PI_NAMEs: WITSCHEY, WALTER R.T. (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adenine;Adenine Nucleotides;Adenosine;Adenosine Triphosphate;Affect;Age;age related;age related decline;Aging;Amides;Amines;Attenuated;Biological Assay;Biological Markers;biomedical scientist;Brain;Carnosine;Chemical Shift Imaging;Chemicals;Collaborations;commercialization;contaminated water;curve fitting;Data;Detection;Development;Diagnosis;Disease;disease diagnosis;Doctor of Philosophy;efficacy evaluation;experience;experimental study;Friedreich Ataxia;Glutamates;Glutamine;Goals;healthy volunteer;Heart;Homeostasis;Human;human subject;Imidazole;improved;in vivo;Institution;magnetic field;Magnetic Resonance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Magnetism;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Metabolic;metabolic imaging;Metabolism;Methodology;Methods;Mitochondrial Diseases;Modeling;Molecular;Muscle;Muscular Dystrophies;Myocardial Infarction;Myocardium;N-acetylaspartate;Nerve Degeneration;new technology;next generation;Niacinamide;Nicotinamide adenine dinucleotide;Noise;novel;novel strategies;Pathologic;Phase;Phosphocreatine;Physiologic pulse;precision medicine;Property;Protons;Qualifying;Rattus;Recovery;Relaxation;Resolution;Role;Scheme;Services;Signal Transduction;Skeletal Muscle;Spectrum Analysis;synergism;targeted treatment;Techniques;Technology;technology development;technology research and development;therapeutic evaluation;Time;Tissues;Training;Treatment Efficacy;Water;Work

PROJECT_TITLE: Down Field Spectroscopy at Ultrahigh Fields


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Pediatric

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE This proposal requests partial funding for continued support of the annual Symposium on Research in Child Language Disorders (SRCLD), a well-respected meeting for researchers and students in training that is hosted by the Department of Communication Sciences and Disorders at the University of Wisconsin- Madison (http://www.srcld.org/home/home.aspx). Funds will be used to provide travel awards to allow students to participate in the conference, travel costs for invited plenary speakers, website management, and part-time salary support for a conference administrative coordinator.

PI_NAMEs: KAUSHANSKAYA, MARGARITA  (contact);STERLING, AUDRA MARIE

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Accounting;Address;Archives;Area;Award;Child;Child Language;Collaborations;Communication;Communities;cost;Data;Development;Discipline;Disease;doctoral student;Evaluation;Event;Evolution;Faculty;Fees;Fostering;Funding;Future;Genetic;Goals;graduate student;Grant;Home;improved;Information Dissemination;interest;International;Language;Language Development;Language Disorders;Learning;Link;meetings;Methodology;National Institute of Child Health and Human Development;National Institute on Deafness and Other Communication Disorders;Neurosciences;Oral;Outcome;Paper;Participant;podcast;Postdoctoral Fellow;posters;pre-doctoral;Principal Investigator;Privatization;Production;programs;Psycholinguistics;Psychology;Publishing;Request for Proposals;Research;research and development;Research Personnel;Research Project Grants;response;Schedule;Science;Scientist;Series;social;student participation;Student Selections;Students;symposium;theories;Time;Training;Travel;Underrepresented Minority;underrepresented minority student;United States National Institutes of Health;Universities;virtual;Wages;web site;Wisconsin;Woman;Work

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Cardiovascular

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Narrative The goal is to train Ph.D. students and post-doctoral fellows to fulfill the need for new investigators to discover mechanisms of human disease.

PI_NAMEs: ELROD, JOHN WILLIAM (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Cancer;Machine Learning and Artificial Intelligence;Neurosciences;Precision Medicine

PI_NAMEs: YODH, ARJUN G. (contact)

PROJECT_TERMS: absorption;Address;Anterior;Biological Markers;Blood flow;Brain;brain health;Brain Injuries;Brain region;brain research;brain tissue;Breathing;Calibration;cancer diagnosis;cancer therapy;Cerebrovascular Circulation;Cerebrum;chromophore;classification algorithm;Clinical;Clinical Research;Collection;comparative;Complement;cost;cytochrome c oxidase;Data Analyses;Data Science;deoxyhemoglobin;detector;Development;Devices;Diagnosis;diagnostic value;Diffuse;diffuse optical spectroscopy and imaging;Diffusion;Doctor of Philosophy;Environment;Equation;Euthanasia;Event;Exercise;Exhibits;Fiber;Fingers;Frequencies;frontal lobe;Gases;Hair;Hair Root;Head;Health;healthy volunteer;Heart Arrest;hemodynamics;Heterogeneity;Human;Hypoxia;image reconstruction;Imaging technology;improved;individualized medicine;injured;instrument;instrumentation;Intensive Care;Light;light scattering;Lipids;machine learning algorithm;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Measurable;Measurement;Measures;Mechanics;metabolic abnormality assessment;metabolic imaging;Metabolism;Methods;Microdialysis;millimeter;Mitochondria;Modeling;molecular marker;Monitor;Motor Cortex;Nervous System Trauma;neuroregulation;Noise;novel;Optical Methods;optical spectra;Optics;Oxidative Phosphorylation;Oxygen;Parietal;Patients;Penetration;personalized care;personalized management;Physiologic Monitoring;Physiological;porcine model;portability;Positioning Attribute;pre-clinical;precision medicine;pressure;Process;Property;Pyruvate;real time monitoring;Research;Resolution;Rest;Scalp structure;Series;Services;Signal Transduction;Skeletal Muscle;spatiotemporal;Spectrum Analysis;Spirometry;statistical and machine learning;success;Surface;System;Techniques;Technology;Thrombectomy;Time;Tissue Extracts;tissue injury;tissue reconstruction;Tissues;tomography;tool;Transcranial magnetic stimulation;treatment response;Validation;Variant;Water;Work

PROJECT_TITLE: Emerging Diffuse Optical Imaging Technologies for Precision Medicine


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project will use data from the robust Midlife in the United States (MIDUS) study to address how social connectedness contributes to reducing the risk of poor mental health outcomes among Black adults in the United States. Quantitative and qualitative findings are proposed to elucidate key psychosocial pathways and mechanisms relevant to the social experiences of Black adults, particularly those who reside in socially disadvantaged urban neighborhoods. Results are anticipated to have broad translational importance for reducing racial health inequalities and catapult future research on social connectedness in this population.

PI_NAMEs: RANSOME, YUSUF  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adult;Affect;Area;Behavioral;biopsychosocial;Black American;Black Populations;Black race;Buffers;care outcomes;caucasian American;Chicago;Chronic;Church;Communities;community intervention;Data;depressive symptoms;Diagnosis;Dimensions;Discrimination;Distress;DSM-III;Ecosystem;Empirical Research;Environment;environmental stressor;Epidemiologist;Equation;evidence base;experience;Exposure to;Factor Analysis;Focus Groups;Foundations;Frequencies;Funding;Generations;Geography;Goals;healing;Health;health determinants;health disparity;health equity;health inequalities;health outcome disparity;HIV diagnosis;improved;Income;indexing;Individual;Inequality;innovation;Intervention;intervention refinement;Knowledge;Life Cycle Stages;Loneliness;Low Income Population;Low Prevalence;Major Depressive Disorder;Measurement;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Mental Health;middle age;minority health;minority health disparity;Modeling;National Institute on Minority Health and Health Disparities;Neighborhoods;novel;Outcome;Pathway interactions;Perception;Personal Satisfaction;Persons;Philadelphia;Police;Policies;Population;Poverty;Prevalence;Process;programs;Property;protective factors;psychologic;psychological distress;Psychometrics;psychosocial;Publishing;Race;racial discrimination;Recovery;Reduce health disparities;Regression Analysis;Religion;Research;Research Support;Resources;response;Risk;Risk Factors;Risk Reduction;Sampling;Scientist;Seasons;Severity of illness;Shapes;social;social adversity;social capital;social cohesion;social disparities;social group;social integration;Social isolation;Social Network;social relationships;social structure;Social support;Spirituality;Strategic Planning;stressor;Structure;substance use;Systems Theory;Techniques;Technology;Testing;theories;therapy development;Trauma;United States;United States National Institutes of Health;Work

PROJECT_TITLE: The Impact of Individual- and Neighborhood-Level Social Connectedness on Mental Health in Black Adults

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: MERCED

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, MERCED

ORG_STATE: CA

PHR: PROJECT NARRATIVE Inflammasomes are large protein complexes that trigger inflammatory responses in the presence of injury or infection. Inflammasome dysfunction leads to chronic inflammation; an underlying cause of several human diseases such as atherosclerosis, rheumatoid arthritis, diabetes, cancer, and neurological disorders. This project is relevant to public health because it proposes to broadly reduce inflammation by capturing extracellular inflammasomes using a hydrogel technology that does not require drug loading and is tunable to potentially create implantable, injectable, and sprayable hydrogels for expanded biomedical applications.

PI_NAMEs: DE ALBA BASTARRECHEA, EVA  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adaptor Signaling Protein;Adopted;Amino Acid Sequence;Anti-Inflammatory Agents;Atherosclerosis;Binding;Biochemical;Cardiovascular Diseases;CASP1 gene;Cell Death;Cell membrane;Cell-Free System;Cells;Cellular biology;cellular imaging;Chronic;Chronic Obstructive Pulmonary Disease;cytokine;cytokine release syndrome;Data;Dependence;design;Detection;Diabetes Mellitus;Diameter;direct application;Disease;DNA;Environment;Enzyme-Linked Immunosorbent Assay;experience;extracellular;Filament;Flow Cytometry;Fluorescence;Fluorescence Microscopy;Fluorescence Spectroscopy;Functional disorder;Funding;Future;Glues;human disease;Hydrogels;Immune;Implant;Infection;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Injectable;Injury;Knowledge;Label;Laboratories;Life;macromolecular assembly;Macrophage;Malignant Neoplasms;Measures;meter;Molecular;Monitor;Multiprotein Complexes;Nervous System Disorder;optic trap;optical traps;Organ;particle;pathogen;Pathogen detection;Pathogenicity;Penetration;Peptide Hydrolases;Pharmaceutical Preparations;Play;protein complex;Protein Engineering;Protein Isoforms;protein protein interaction;Proteins;Public Health;recruit;Regulation;Reporting;Research;Resolution;Rheumatoid Arthritis;Role;Rupture;SARS-CoV-2 infection;self assembly;sensor;Signal Transduction;Sodium Chloride;Structure;Technology;Temperature;Testing;therapeutic target;three dimensional structure;Time;Tissues;ultra high resolution;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: Anti-inflammatory activity of hydrogels designed to capture extracellular inflammasomes