NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Dental, Oral, and Craniofacial Disease;Headaches;Migraine;Neurosciences;Pain Research;Prevention;Sleep Research

PHR: Project Narrative This project will validate the use of a novel, minimally invasive, microchip/video recording system as a platform for testing migraine treatments. We will characterize the physiological and behavioral responses in 3 different migraine models and examine the effects of widely used acute and preventive migraine therapies on these responses. This platform will increase the accuracy and translational value of animal models for migraine for the discovery and characterization of new treatments.

PI_NAMEs: CHARLES, ANDREW C (contact);PRADHAN, AMYNAH AMIR ALI

PROJECT_TERMS: Acute;Address;Animal Model;Animals;Auras;Back;Behavior;behavioral response;Body Temperature;Brain;Calcitonin Gene-Related Peptide;Calibration;Cephalic;Cerebrovascular Circulation;Characteristics;Chronic;Clinical;clinical efficacy;cranium;Data;Development;disability;Disabling;Dose;Estrous Cycle;Facial Expression;Goals;Hair;Head;Head Movements;Headache;Heart Rate;heat stimulus;Human;improved;Individual;Institution;Machine Learning;Measurement;Measures;mechanical allodynia;microchip;Microchip Analytical Procedures;Migraine;migraine treatment;minimally invasive;Modeling;Movement;Mus;Nervous System Disorder;neurovascular;Nitroglycerin;non rapid eye movement;novel;novel strategies;novel therapeutics;Pain;Pain Threshold;Pattern;Phase;Physiological;Posture;Preventive;Preventive therapy;REM Sleep;Research;Respiration;response;screening;Screening procedure;sensor;Sensory;Sleep;Sleep Wake Cycle;Spreading Cortical Depression;Stereotyping;Stress;Sumatriptan;System;Systems Analysis;Testing;Therapeutic;Time;tool;topiramate;Training;treatment effect;Universities;Variant;Video Recording;Washington

PROJECT_TITLE: A novel platform for the discovery and characterization of migraine therapies

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Delirium affects millions of hospitalized older adults each year and increases one’s risk of dementia, functional decline, and death, yet comparatively little is known about delirium in older adults hospitalized for traumatic brain injury (TBI). While older adults suffering from even “mild” TBI are at increased risk for subsequent dementia and disability, whether delirium contributes to these worsened outcomes is unclear. This project combines an investigation of age-related delirium risk factors, using clinical assessments and novel biomarkers, with meaningful long-term clinical outcomes, to ultimately improve cognitive and functional recovery for older adults with mild TBI.

PI_NAMEs: LAHUE, SARA CATHERINE (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Accounting;Acute;Address;Adult;adverse outcome;Affect;Age;age related;age related biomarkers;aged;Aging;aging mechanism;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Biochemical Markers;biological age;Biological Aging;Biological Markers;Biology of Aging;Biometry;Biostatistical Methods;Blood;blood-based biomarker;career;career development;Career Mobility;Cessation of life;Chronology;Clinical;Clinical assessments;Cognition;Cognitive;cognitive enhancement;cognitive function;cognitive recovery;cognitive testing;cohort;comparative;confusion assessment method;Data;Delirium;Dementia;dementia risk;Diagnosis;Diagnostic;disability;DNA Methylation;Elderly;Enrollment;epigenetic clock;Exclusion;Fellowship;Foundations;functional decline;functional outcomes;Future;Geriatrics;Glasgow Coma Scale;Glasgow Outcome Scale;Goals;Health;Hospitalization;hospitalization rates;Impaired cognition;Impairment;improved;improved outcome;Incidence;indexing;Individual;Injury;Inpatients;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Lead;Leadership;lens;Link;Literature;Measures;mental state;Mentors;mild traumatic brain injury;modifiable risk;Multicenter Studies;Multiple Trauma;neglect;Nervous System Disorder;Nervous System Trauma;Neurologic;Neurologist;Neurology;novel marker;older adult;Outcome;Outcomes Research;Patient Care;Patient-Focused Outcomes;Patients;Physical Function;Population;Prevalence;Prevention;Prognostic Marker;prospective;Prospective cohort;Qualifying;Quality of life;Questionnaires;Recovery;Recovery of Function;Research;research clinical testing;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Risk;Risk Factors;San Francisco;Severities;skills;Structure;Subgroup;success;Testing;Therapeutic;therapeutic target;Time;Training;Training Programs;Traumatic Brain Injury;Unemployment;United States;United States National Institutes of Health;Wages

PROJECT_TITLE: Characterizing the Relationship Between Delirium and Biological Age in Traumatic Brain Injury: Implications for Cognitive Decline in Older Adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Narrative Current mouse models of the highly lethal Glioblastoma (GBM) are not clinically relevant in humans due to huge dissimilarities of size, structure, and physiology. Here, we propose to develop a large animal syngeneic pig glioma model using a local anti-inflammatory treatment and the innate immunosuppressive microenvironment with optimum engraftment conditions at implantation site of oncogene activated transformed pig neural progenitor cells (Tr-pNPCs) or Cre-responsive virus. This first-in-kind, clinically relevant syngeneic pig GBM model will better recapitulate human brain physiology, improve clinical imaging, predict treatment responses, and ultimately provide better outcomes in GBM patients as compared to current GBM mouse models.

PI_NAMEs: HORNER, PHILIP J;ROSTOMILY, ROBERT C (contact);VISHNOI, MONIKA

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Animal Model;Animals;Anti-Inflammatory Agents;Basic Science;Benchmarking;Biology;Brain;Brain Neoplasms;brain size;Cells;Cephalic;Chronic;clinical imaging;clinical material;clinically relevant;cohort;Communities;Development;Dexamethasone;Disease Progression;Disseminated Malignant Neoplasm;Drug resistance;Engraftment;epidermal growth factor receptor VIII;Evaluation;experimental study;Failure;Family suidae;Fostering;Future;Gadolinium;Generations;Glioblastoma;Glioma;glioma cell line;graft failure;Growth;Heterogeneity;high risk;Histologic;Human;human disease;Image;imaging study;Imaging Techniques;Immune;immune activation;Immune response;Immune system;Immunity;Immunocompetent;Immunohistochemistry;immunoreaction;Immunosuppression;Immunotherapy;Implant;implantation;improved;improved outcome;In Situ;in vivo;Incidence;Infiltration;Inflammation;Inflammatory;Injections;insight;Knowledge;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Measures;Mediating;Metabolic stress;Miniature Swine;model development;Modeling;Molecular;Monitor;mouse model;Mus;Mutation;neoplastic cell;nerve stem cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear Pore Complex;Nude Mice;Oncogenes;Oncogenic;Oncopig;Operative Surgical Procedures;Outcome;Pathology;Patients;personalized immunotherapy;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Placebos;porcine model;Postoperative Period;pre-clinical;pre-clinical assessment;pre-clinical research;Precision therapeutics;Prediction of Response to Therapy;pressure;Prognosis;Property;Publishing;Quality of life;Reporting;Research;research study;Residual state;Rodent;Rodent Model;Sampling;Site;Stem cell transplant;Structure;subventricular zone;Tacrolimus;Techniques;Testing;Therapeutic;Time;TP53 gene;Transgenes;translational study;Trauma;treatment response;tumor;Tumor Biology;tumor growth;tumor initiation;tumor microenvironment;tumor-immune system interactions;tumorigenesis;tumorigenic;Tumorigenicity;Viral;Virus;white matter;Xenograft procedure

PROJECT_TITLE: Development of a pre-clinical syngeneic pig glioma model for research and translational studies

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M1)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PROVIDENCE

ORG_NAME: PROVIDENCE VA  MEDICAL CENTER

ORG_STATE: RI

PHR: Veterans with bipolar disorder (BP) and comorbid substance use disorders (SUDs) have poor treatment adherence and poor clinical outcomes, high rates of suicide, and increased psychiatric hospitalization. They are at particularly high risk for treatment nonadherence when transitioning from psychiatric hospitalization to outpatient care, with little to no treatment options available to improve care of this high-risk population at the critical period following hospital discharge. The current project will test the effectiveness of Integrated Treatment Adherence Program (ITAP), which is the first adjunctive psychosocial program specifically designed to improve treatment adherence and reduce suicidality, bipolar symptoms, and substance use among high-risk patients with BP-SUD. If shown effective, ITAP could be easily and efficiently adopted as standard care for hospitalized Veterans with co-occurring BP and SUD within VHA. Findings from this study will inform clinical and policy efforts on the implementation of BP treatment for Veterans with co-occurring SUD post-discharge.

PI_NAMEs: GAUDIANO, BRANDON A;METRIK, JANE  (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adoption;Aftercare;Alcohol consumption;Alcohols;Ambulatory Care;Appointment;Area;Behavior;Behavioral;Bipolar Disorder;Blinded;Caring;Cessation of life;Clinical;comorbidity;contextual factors;critical period;Data;Death Rate;depressive symptoms;design;Disease;Dissemination and Implementation;Dose;Drug usage;effective intervention;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Electronics;Emergency department visit;Evaluation;evidence base;Feeling suicidal;follow-up;formative assessment;Future;future implementation;Gender;Health Care Costs;Health Services;high risk;high risk population;hospital readmission;Hospitalization;Hospitals;Hybrids;implementation efforts;implementation framework;Implementation readiness;implementation strategy;implementation trial;improved;innovation;inpatient psychiatric treatment;inpatient service;Intervention;intervention effect;intervention program;Leadership;Manic;Measures;Mediating;Mediator;medication compliance;Mental Health;Methodology;Monitor;mood symptom;Moods;Opioid;opioid overdose;organizational readiness;Outcome;Participant;Patient Discharge;Patients;Perception;Persons;Pharmaceutical Preparations;Pharmacotherapy;Policies;Population;Populations at Risk;Prevalence;preventive intervention;primary outcome;Problem Solving;process evaluation;programs;psychiatric inpatient;psychosocial;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reducing suicide;Relapse;Research;Research Priority;safety assessment;Sampling;scale up;secondary outcome;Severities;Site;skills;Social Workers;standard care;standard of care;Substance abuse problem;substance use;Substance Use Disorder;substance use treatment;Suicide;Suicide attempt;Suicide prevention;suicide rate;Symptoms;Telephone;Testing;Therapeutic;therapy design;Training;treatment adherence;treatment as usual;treatment effect;Treatment outcome;treatment risk;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Post-Hospital Intervention for Veterans with Comorbid Bipolar and Substance Use Disorders

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: A significant proportion of Veterans with substance use disorders (SUDs) have co-occurring psychiatric disorders, the combination of which frequently leads to high inpatient service utilization. Homelessness and higher risk for suicide is common among this population. The combination of SUD with co-morbid MH diagnoses warrants innovative treatment approaches that: a) identify and treat patients during their most vulnerable periods; b) leverage technology; c) partner with current VA programs (e.g. Home Telehealth) and operational priorities (i.e., VHA Handbook 1160.06), toward the goal of reducing inpatient admissions, enhancing treatment engagement and reducing SUD. This study investigates the effectiveness of Combined Recovery Program (CRP) for Veterans with SUDs in the inpatient setting and Home Telehealth in the aftercare setting. Outcomes are assessed at 1 and 3-month follow-up using a multi-modal approach. The ultimate goal is to increase outpatient utilization, reduce substance use, and reduce inpatient/ED visits.

PI_NAMEs: SANTA ANA, ELIZABETH J (contact)

PROJECT_TERMS: Address;Admission activity;Aftercare;Age;Alcohols;Ambulatory Care;Area;arm;Behavior;Care given by nurses;Caring;Cellular Phone;Chronic;Communities;community engagement;Community Integration;comorbidity;cost;COVID-19 pandemic;Data;design;Development;Devices;Diagnosis;Drug Use Disorder;Effectiveness;Eligibility Determination;Emergency department visit;Evaluation;Event;Exhibits;follow-up;Frequencies;future implementation;Goals;handbook;Health;health care service;Health Services Accessibility;Health Technology;health training;Healthcare;Healthcare Systems;high risk;Home;Homelessness;hospital readmission;Hospitalization;Hospitals;Housing;housing instability;illicit drug use;Impairment;implementation barriers;implementation evaluation;implementation intervention;improved;innovation;inpatient psychiatric settings;inpatient service;Inpatients;Intervention;Interview;Life;Maintenance;Measures;meetings;Mental disorders;Mental Health;Mental Health Services;Methods;Modeling;Monitor;motivational enhancement therapy;multimodality;Nicotine Dependence;novel;Nurses;Occupational;Outcome;Outcome Assessment;Outpatients;Participant;patient response;Patients;Performance;Phase;Population;preservation;primary outcome;Procedures;Process;programs;Psychiatric therapeutic procedure;Quality of life;Randomized;readmission rates;Recommendation;Recovery;recruit;reduced substance use;Relapse;relative effectiveness;Reporting;Research Personnel;Research Priority;secondary outcome;Self Management;service gap;service utilization;Services;skills;skills training;social;Social Functioning;substance use;Substance Use Disorder;substance use treatment;suicidal;suicidal risk;Technology;telehealth;Training;treatment arm;treatment as usual;treatment effect;Veterans;web app

PROJECT_TITLE: Impact of Combined Recovery Program and Home Telehealth Among Veterans with substance use disorders in the VA Inpatient Setting


ORG_CITY: ANN ARBOR

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: The proposed research will adapt CPT into a brief format using empirical methods. This project is relevant to Veterans’ health because will improve treatment effectiveness, reduce attrition, and improve efficiency, enabling providers to treat more Veterans with need. This proposal is directly responsive to the 2021 HSR&D mental health priorities to increase the engagement and retention of Veterans in evidence-based therapies for PTSD and to develop innovative and efficient models of healthcare delivery. It addresses the cross-cutting HSR&D Implementation Science priority to use a theory-based method to improve uptake of effective practices. It is also directly responsive to the VA National Center for PTSD’s operational priorities to develop adapted treatments that attend to patient preferences and to improve treatment efficiency, effectiveness, and engagement.

PI_NAMEs: SRIPADA, REBECCA KAUFMAN (contact)

PROJECT_TERMS: Abbreviations;Address;Adherence;Age;Characteristics;clinical practice;clinically significant;Cognition;Cognitive;design;Distress;Dose;Dropout;Drops;DSM-V;effective intervention;Effectiveness;effectiveness testing;effectiveness trial;Elements;Engineering;Ensure;evidence base;Evidence based treatment;Exclusion Criteria;experience;Experimental Designs;experimental study;follow-up;Future;Goals;Health;Health Priorities;Health Services Accessibility;implementation science;improved;improved outcome;Individual;innovation;Institute of Medicine (U.S.);Intervention;late life;Logistics;Measures;Mediating;Mediator;medical specialties;Mental Health;Methodology;Methods;multi-component intervention;multiphase optimization strategy;novel;Outcome;Participant;Patient Preferences;Performance;Personal Satisfaction;personalized intervention;personalized medicine;Persons;physically handicapped;post 9/11;Post-Traumatic Stress Disorders;premature;Process;Productivity;Provider;Psychotherapy;Quality of life;Randomized;reduce symptoms;Research;Research Priority;Service delivery model;Severities;sex;substance use;suicidal risk;Symptoms;System;telehealth;Testing;theories;Therapeutic;Time;Training Programs;Trauma;Treatment Effectiveness;treatment response;uptake;Veterans;Work

PROJECT_TITLE: Using the Multiphase Optimization Strategy to Adapt Cognitive Processing Therapy


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Nutrition;Obesity

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Obesity affects a large fraction of adults and children and is a major risk factor for leading causes of death such as heart attack and stroke. One major cause of poor health outcomes in obesity is increased inflammation in the fat due to a reduction in regulatory T cells (Tregs), a type of cell that normally suppresses inflammation. Therefore, this work will focus on the identifying the causes of this reduction in Tregs, with a focus on cell cholesterol, so we can rescue these cells and improve health outcomes associated with obesity.

PI_NAMEs: ELKINS, CODY  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Ablation;Adipose tissue;Adoptive Transfer;Adult;Affect;Antigens;Automobile Driving;Biological Assay;Cardiovascular Diseases;Cause of Death;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Death;Cell Physiology;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Child;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Chronic;Clonal Expansion;CRISPR/Cas technology;Data;Ear;Exhibits;experimental study;Fatty acid glycerol esters;feeding;Flow Cytometry;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Germ Lines;Goals;Health;Heterogeneity;High Fat Diet;Homeostasis;Immunization;Impairment;improved;in vitro Assay;in vivo;Inflammation;Insulin Resistance;interest;Knock-out;Liver;LoxP-flanked allele;Lung;Lymphoid;Mediating;Membrane Microdomains;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;Molecular;mouse model;Mus;Myocardial Infarction;nanocluster;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Outcome;Pathway interactions;Peptides;Phenotype;Play;poor health outcome;Population;preventable death;programs;Proliferating;Publishing;Receptor Signaling;recruit;Regulatory T-Lymphocyte;Risk Factors;RNA;Role;single cell analysis;Societies;Stroke;subcutaneous;Surface;Symptoms;System;T cell receptor repertoire sequencing;T-Cell Proliferation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte Subsets;Testing;therapeutic target;Tissues;Transcript;transcriptomics;Transgenic Mice;Transgenic Organisms;uptake;Visceral;Work

PROJECT_TITLE: The importance of Treg-intrinsic cholesterol metabolism for visceral adipose tissue Treg homeostasis, phenotype, and function


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Maternal Health;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PHARMACOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PRIOJECT NARRATIVE A key step in placental development is the invasion of trophoblast cells into the endometrium of the uterus. Dysregulation of this process can lead to severe pregnancy complications including preeclampsia and miscarriage, but the cell signaling mechanisms controlling the process of trophoblast migration are unclear. This proposal will establish a novel signaling axis governing trophoblast migration, and will shed light on how signaling becomes dysregulated during this process, potentially highlighting targets to be explored in therapies for common pregnancy complications related to aberrant placental development.

PI_NAMEs: SONG, CLAIRE  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Ablation;Adhesions;Affect;Biological Assay;Biosensor;Blood Vessels;cell motility;Cell Polarity;Cells;Cellular Morphology;Chorionic villi;clinically relevant;CRISPR/Cas technology;Cultured Cells;Cytoskeletal Modeling;Cytoskeleton;cytotrophoblast;Data;Docking;Endometrium;Family;Fetal Growth Retardation;Fetus;Genes;Guanosine Triphosphate Phosphohydrolases;Human;In Vitro;inhibitor;Invaded;JUN gene;kinase inhibitor;knock-down;Literature;MAPK8 gene;Mediating;Mediator;migration;Mitogen-Activated Protein Kinases;Molecular;Molecular Target;Monomeric GTP-Binding Proteins;Mothers;mutant;N-terminal;novel;Outcome;overexpression;Phenotype;Phosphorylation;Phosphotransferases;Placenta;Placentation;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Process;Proteins;Publishing;Regulation;rho;rho GTP-Binding Proteins;rho GTPase-activating protein;Role;Signal Transduction;Site;Spontaneous abortion;Tissue Sample;Tissues;trophoblast;Uterus;Vascular blood supply;Villous;wound healing

PROJECT_TITLE: Rho GTPase regulation in trophoblasts by c-Jun N-terminalkinase signaling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: DENVER

ORG_NAME: COLORADO STATE DEPT/PUB HLTH & ENVIRONMT

ORG_STATE: CO

PHR: Project Narrative – Component A (Core Surveillance) The Pregnancy Risk Assessment Monitoring System (PRAMS) is a surveillance project of the Centers for Disease Control and Prevention and the Colorado Department of Public Health and Environment. PRAMS collects state-specific, population-based data on maternal attitudes, behaviors, and experiences before, during, and shortly after pregnancy. PRAMS data are used by state and local governments and their stakeholders to plan and evaluate programs and policies aimed at improving the health of mothers and infants.

PI_NAMEs: TOLLIVER, RICKEY  (contact)

PROJECT_TITLE: DP21-001 Pregnancy Risk Assessment Monitoring System (PRAMS)


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Poor sleep is a nearly universal experience for Veterans with post-traumatic stress disorder (PTSD), and the current first-line psychotherapy for insomnia disorder - cognitive-behavioral therapy for insomnia (CBT-I) - is less beneficial for individuals with comorbid PTSD. This study will evaluate a newly-developed psychotherapy for insomnia disorder in the context of PTSD called “Acceptance and the Behavioral Changes to treat Insomnia (ABC-I), which incorporates the core behavioral components of CBT-I with the theoretical framework and techniques from Acceptance and Commitment Therapy (ACT). The results of this study will improve knowledge about the best non-medication treatments for insomnia disorder for Veterans with PTSD.

PI_NAMEs: MARTIN, JENNIFER L (contact)

PROJECT_TERMS: Address;Adopted;Adoption;Aftercare;Anxiety;Area;Attenuated;avoidance behavior;Behavior;Behavioral;Clinical;clinical care;Cognitive;Cognitive Therapy;Combined Modality Therapy;Comorbid Insomnia;comorbidity;Data;design;diaries;effective therapy;effectiveness evaluation;evidence base;Exclusion Criteria;Exercise;experience;Feeling suicidal;flexibility;follow-up;Health;improved;improvement on sleep;Individual;innovation;interest;Intervention;Knowledge;Measures;Medicine;Mental Depression;Mental Health;Methodology;mindfulness;Neurobehavioral Manifestations;novel;Outcome;Outcome Measure;Outcome Study;Pathway interactions;Patients;poor sleep;Population;Post-Traumatic Stress Disorders;Process;Process Measure;programs;Provider;psychologic;Psychotherapy;Quality of life;Randomized;randomized trial;Recommendation;reducing suicide;Relaxation;response;Services;Sleep;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;sound;Specific qualifier value;standard care;Stimulus;Symptoms;Techniques;Testing;Therapeutic Intervention;therapy design;Time;Training;Training Programs;treatment response;trial design;Veterans;women's treatment;Work

PROJECT_TITLE: A Novel Acceptance-based Treatment for Insomnia in Veterans with Post-Traumatic Stress Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: It has become increasingly clear that the genome, gut microbiome, diet, lifestyle, socioeconomic status, and environmental exposures all effect an individual’s metabolic state, contributing to brain health and Alzheimer’s disease (AD). In this application, we propose to build research infrastructure that can expand our coverage of the chemical exposome in large AD and epidemiological studies to evaluate the possible effects of environmental exposures on cognition and brain health; where all data will be made publicly available through Sage Bionetworks. We will coordinate with other large exposome initiatives including the Neighborhood Atlas (socioeconomic disadvantage), HHEAR and Netherlands Exposome Initiative (geolocation), biobanks and epidemiological studies (UK Biobank, FHS, Rotterdam) to enhance our understanding of the influences of the exposome in AD.

PI_NAMEs: FIEHN, OLIVER ;GOLDSTEIN, LEE E.;KADDURAH-DAOUK, RIMA F (contact);WISHART, DAVID

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Acceleration;Address;Administrative Supplement;Affect;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnostic;Alzheimer's disease related dementia;Animal Model;Atlases;Autopsy;Big Data;Bile Acids;biobank;Biochemical;Biological Markers;Biological Models;Blood;Blood specimen;Brain;Brain Diseases;brain health;Brain imaging;Brain region;Categories;Cells;cerebral atrophy;Chemical Exposure;Chemicals;Cholesterol Homeostasis;Classification;Clinical Data;Cognition;Cognitive;cognitive change;cognitive function;cohort;Collaborations;Communities;comparative;Complex;Consensus;Data;data harmonization;data integration;Data Pooling;data sharing;Databases;Dementia;Diet;Dietary Component;Dietary Intervention;Disease;Disease Marker;environmental chemical exposure;Environmental Exposure;environmental justice;epidemiology study;ethnic diversity;Ethnic Origin;European;Exposure to;Failure;fluorodeoxyglucose positron emission tomography;Food;Funding;Generations;Genetic;Genetic Risk;Genome;Genomics;Geography;Glucose;Goals;Government;gut bacteria;gut microbiome;gut-brain axis;Health;Human;human data;Image;immune function;Impaired cognition;in vitro Model;Individual;Industry;Inflammation;Infrastructure;insight;Intervention Studies;Investments;Joints;Knowledge;Knowledge Portal;Lead;Life Style;lifestyle intervention;Link;lipidomics;Liver;liver function;Longitudinal cohort study;Maps;Measures;Medicine;Meta-Analysis;Metabolic;Metabolic Diseases;metabolic imaging;metabolome;metabolomics;Mind;Mitochondria;Modeling;Molecular;Molecular Disease;mouse model;Neighborhoods;Netherlands;neuroimaging;Nonprofit Organizations;novel;novel therapeutic intervention;Participant;Pathogenesis;Peripheral;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Play;Population Study;Positron-Emission Tomography;pre-clinical;Preventive measure;Process;Reporting;Research;Research Infrastructure;Research Personnel;resilience;Resources;Role;Sampling;Secure;Sex Differences;socioeconomic disadvantage;Socioeconomic Status;socioeconomics;Specimen;System;Technology;Testing;Time;toxicant;Toxicant exposure;Work

PROJECT_TITLE: The Role of Chemical Exposures in Alzheimer's Disease (AD) and its Trajectory

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-P (M2)]


ORG_CITY: NORTH LITTLE ROCK

ORG_NAME: CENTRAL ARKANSAS VETERANS HLTHCARE SYS

ORG_STATE: AR

PHR: Project Narrative  The proposed aims address a critically important gap in Veterans’ health care - specifically, the need to identify effective strategies for linking Veterans in VHA PC who screen positive for hazardous drinking and PTSD and/or depression to alcohol care. Our VHA partners in the Office of Primary Care and Office of Mental Health and Suicide Prevention are highly interested in implementing SLAC nationally should it be found to be effective in a subsequent, fully powered RCT. The aims of this proposal support VA HSR&D priorities (Access to Care, Mental Health, and Primary Care) by adapting and pilot testing a novel intervention to help facilitate Veterans’ linkage to alcohol care. Increasing the use of care among this high need Veteran population is likely to lead to significant reductions in acute health care costs and improved outcomes.

PI_NAMEs: CUCCIARE, MICHAEL ANTHONY (contact);TIMKO, CHRISTINE D

PROJECT_TERMS: Academy;Acute;Address;adverse outcome;Age;Alcohol abuse;Alcohol consumption;alcohol screening;alcohol use disorder;Alcohols;Area;barrier to care;Behavioral;care seeking;Caring;Chronic;Clinical;clinical care;Clinical effectiveness;comorbidity;cost outcomes;Counseling;Decision Making;design;diagnostic criteria;Disease;drinking;Educational process of instructing;Effectiveness;eHealth;Enrollment;evidence base;Evidence based intervention;follow-up;hazardous drinking;Health Care Costs;Health Personnel;Health Services Accessibility;Healthcare;High Prevalence;high risk;Hybrids;Improve Access;improved;improved outcome;information gathering;innovation;interest;Intervention;Interview;Knowledge;Letters;Link;Measures;Medical;medical specialties;medication-assisted treatment;meetings;member;Mental Depression;Mental Health;Mental Health Services;Methodology;military veteran;Monitor;Motivation;novel;novel strategies;operation;Outcome;Patients;pilot test;pilot trial;Population;Post-Traumatic Stress Disorders;Primary Care;primary care provider;primary care setting;Provider;Psychologist;Randomized, Controlled Trials;Recommendation;Reporting;Risk;Role;satisfaction;screening;Services;Site;skills;Social Workers;substance use;Substance Use Disorder;Suicide prevention;telephone delivery;Testing;Uncertainty;Veterans

PROJECT_TITLE: Multi-site Pilot Trial of Strengths-based Linkage to Alcohol Care (SLAC) for Hazardous Drinkers in Primary Care


PHR: Major recent transformations in health care financing and delivery within and outside of the Department of Veterans Affairs (VA) are now presenting Veterans with unprecedented health care choices. These choices give Veterans opportunities to make decisions about their use of VA and non-VA health care that optimize the timeliness, affordability, quality, and patient-centeredness of their care. However, these decisions also carry great potential for unintended consequences if they are not well-informed. Despite such high stakes, little is known about how Veterans are currently making decisions about using VA and non-VA health care, what information they want to use in this decision-making, and how the provision of information to Veterans about their health care options could be improved. This research will examine how Veterans are now making decisions about using VA and non-VA health care and identify promising new strategies to better support Veterans in making well-informed, personalized decisions about their VA and non-VA health care options.

PI_NAMEs: KULLGREN, JEFFREY  (contact)

PROJECT_TERMS: Acceleration;care preference;Caring;Characteristics;Communities;Community Healthcare;Community Networks;Complex;Decision Making;Deductibles;design;Eligibility Determination;Evolution;experience;Focus Groups;Geography;Health;health care cost/financing;health care service;health care settings;health plan;Healthcare;Healthcare Systems;improved;innovation;insight;Interview;Learning;Low income;Measures;Medicaid;Methodology;Methods;Participant;patient oriented;patient population;Perception;personalized decision;Policies;Policy Analysis;Privatization;Process;programs;Provider;public health insurance;Qualitative Methods;Reporting;Research;Resource Allocation;Sampling;Science;Services;Source;Statutes and Laws;Structure;success;Surveys;System;Translations;United States Department of Veterans Affairs;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Optimizing Veteran Decision-Making About Use of VA and Non-VA Health Care

STUDY_SECTION_NAME: HSR-2 Behavioral, Social, and Cultural Determinants of Health and Care[HSR2]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Defects in cranial neural crest development lead to a variety of craniofacial diseases and malformations affecting the face, e.g. Treacher Collins syndrome, DiGeorge syndrome, and cleft palate to name a few. In this project, I will investigate the regulation and mechanism of function of the secreted protein Draxin, which will significantly enhance our understanding of the regulation of cranial neural crest delamination and migration, providing new scientific avenues for translational research applications in the treatment of craniofacial defects.

PI_NAMEs: HUTCHINS, ERICA  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Affect;antagonist;beta catenin;Binding;Biochemistry;Bioinformatics;Biological Assay;Cadherins;Cartilage;Cell Adhesion;Cell Adhesion Molecules;Cell-Cell Adhesion;Central Nervous System;Cephalic;Chick;ChIP-seq;Cleft Palate;Co-Immunoprecipitations;craniofacial;Craniofacial Abnormalities;craniofacial structure;Data;Defect;Development;DiGeorge Syndrome;Disease;Down-Regulation;E-Cadherin;Embryo;Embryology;epithelial to mesenchymal transition;Etiology;Event;experimental study;Extracellular Matrix Proteins;Face;Fluorescence Resonance Energy Transfer;Gelatinase B;Gene Expression;Genomic Segment;Goals;Head;Image;Immunoprecipitation;In Situ Hybridization;in vivo;Integrins;knock-down;Laminin;laminin alpha5;Lead;Ligation;Light;Maintenance;malformation;Mandibulofacial Dysostosis;Mediating;Mentors;Messenger RNA;Microscopy;migration;Molecular;mRNA Expression;Mutate;Mutation;N-Cadherin;Names;Neural Crest;Neural Crest Cell;neural plate;Neural tube;neuroepithelium;overexpression;Pathway interactions;Phase;Play;Population;Post-Transcriptional Regulation;posttranscriptional;Protein Secretion;Proteins;public health relevance;receptor;Regulation;Reporter;Research;RNA;RNA-Binding Proteins;Role;sensor;Site;Skeleton;Snails;spatiotemporal;stem cell population;Tail;Techniques;Time;Translational Research;Untranslated Regions;Up-Regulation;WNT Signaling Pathway

PROJECT_TITLE: Characterization of the roles and regulation of Draxin in cranial neural crest


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative This project will focus on developing and validating new tools to measure financial hardship across families, including individuals living with Alzheimer's disease and related dementias (ADRD) and their families, partners, and caregivers. These measures of financial hardship in ADRD will be publicly available to inform researchers and policymakers about the extent of the burden and any disparities in who is most impacted. Ultimately, new measurement tools of financial hardship will address these disparities and improve quality of life for individuals living with ADRD and their families, partners, and caregivers, by providing early identification of financial stress and burden.

PI_NAMEs: SHIN, JU YOUNG  (contact);TULSKY, DAVID SCOTT

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Alzheimer's disease care;Alzheimer's disease related dementia;Black race;Calibration;care costs;Caregiver Burden;Caregivers;Caring;Child;clinical practice;cost;cost estimate;Dementia;dementia care;Development;Disparity;Disparity population;Early identification;Economic Burden;experience;Family;Family Caregiver;Family member;Financial Hardship;Goals;grandchild;Health;Health care facility;health care service;health disparity;Healthcare Systems;Hispanic Americans;Home;Home Care Services;improved;Income;Individual;Insurance;intergenerational;Intervention;life time cost;Literature;Living Costs;Long-Term Care;lost earning;loved ones;Low income;marginalization;marginalized population;Measurement;Measures;Medical;Medical Care Costs;Methods;Modification;National Institute on Aging;Nature;novel;novel strategies;older adult;Persons;Policies;Policy Maker;Positioning Attribute;Productivity;Psychometrics;Qualitative Methods;Quality of life;Quality of Life Assessment;Reporting;Research Personnel;Resources;response;Risk;screening;Shapes;socioeconomics;Spouses;Standardization;theories;tool;Uninsured Medical Expense;user-friendly;Work

PROJECT_TITLE: Development of Measure(s) of Financial Hardship and Health Disparities among Individuals Living with ADRD and Their Family Caregivers

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Many consider proton beam radiotherapy (PBRT) to be a promising treatment for children with brain tumors as it may preserve cognitive functioning without sacrificing disease control. This will be the first large-scale study to prospectively compare symptom burden, treatment toxicity, and neurocognitive change between patients treated with PBRT vs. conventional photon radiotherapy on comparable treatment protocols and to assess important measures of daily functioning that will quantify the clinical significance of any differences identified between groups in survivorship. Ultimately, this line of research is intended to: (1) help physicians and families better understand the relative effect of PBRT on symptoms and neurocognitive functioning to inform treatment decisions, and (2) provide functional outcome data to be used toward justifying or reconciling the high cost and access limitations currently associated with PBRT.

PI_NAMEs: HINDS, PAMELA S;KAHALLEY, LISA SCHUM (contact);MABBOTT, DONALD

PROGRAM_OFFICER_NAME: SCHWEPPE, CATHERINE ANN

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Aftercare;Attention;Australia;Awareness;Benefits and Risks;Brain;Brain Neoplasms;brain tissue;Canada;Cancer Center;Cancer Patient;Child;Childhood Brain Neoplasm;Childhood Injury;Clinical;clinically significant;Cognitive;cognitive function;cohort;contextual factors;cost;Costs and Benefits;Cranial Irradiation;daily functioning;Data;Decision Making;Deposition;design;Development;disability;Disease;disorder control;Dose;Education;Exhibits;experience;Face;Family;Fatigue;functional independence;functional outcomes;Goals;Hospitals;Impact evaluation;Impaired cognition;improved;Knowledge;Late Effects;Lead;Life;Longitudinal cohort;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mediating;Medical;member;Methodology;Modality;Modeling;multidisciplinary;Neurocognitive;Neurocognitive Deficit;neurodevelopment;neurotoxicity;Normal tissue morphology;North America;Occupational;Outcome;Patients;Pediatric Hospitals;Pediatric Oncology Group;Photons;Physicians;Population;Positioning Attribute;predictive modeling;preservation;Process;prospective;Protocols documentation;proton beam;Protons;Quality of life;Radiation;radiation delivery;Radiation therapy;Radiation Toxicity;recruit;reduce symptoms;Research;Research Infrastructure;Risk;Sampling;Short-Term Memory;Site;social;Social Problems;Socioeconomic Status;standard of care;Survivors;survivorship;Symptom Burden;symptom treatment;Symptoms;Texas;theories;Time;Tissues;Toxic effect;treatment group;Treatment Protocols;Treatment-related toxicity;tumor;Work;x-ray irradiation

PROJECT_TITLE: Comparison of Symptom Burden/Toxicity, Neurocognitive Change, and Functional Outcomes in Pediatric Brain Tumor Patients Treated with Proton vs. Photon Radiotherapy.

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Women's Health Research

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: 2. PROJECT NARRATIVE The proposed research is relevant to public health because if a low-cost, community-based weight loss program with a national infrastructure is effective at weight loss among African American breast cancer survivors with excess weight, it has the potential to reduce of the health disparities of excess weight; breast cancer recurrence and mortality; and cardiovascular disease mortality among African American breast cancer survivors. The proposed research is relevant to the part of the NIH mission that pertains to enhancing health and reducing illness and disability.

PI_NAMEs: MITCHELL, NIA SCHWANN (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;adverse outcome;African American;African American population;African American Women;arm;Biological Markers;Bluetooth;Body Weight decreased;Breast Cancer Patient;Breast Cancer Risk Factor;Breast Cancer survivor;Breast Cancer survivorship;cancer recurrence;Cancer Survivor;Cardiovascular Diseases;Cardiovascular system;Characteristics;clinically significant;Communities;cost;Counseling;Country;Data;Databases;Dietitian;disability;Disease Outcome;Effectiveness;effectiveness testing;Electronic Health Record;Event;evidence base;Exercise;experience;Focus Groups;Future;Goals;Grant;Health;Image;improved;Infrastructure;innovation;Institution;Intervention;Investments;Life Style;Maintenance;Malignant Breast Neoplasm;Measures;Mission;Morbidity - disease rate;mortality;nutrition;Nutritionist;Obesity;Outcome;Participant;Patient Recruitments;peer;Persons;Phase;Physical activity;Pilot Projects;pilot test;Population;Process;programs;Public Health;Quality of life;Recipe;Recommendation;recruit;Reduce health disparities;Research;Resources;Serum;Sister;Site;Surveys;Telephone;Test Result;Testing;Time;transmission process;treatment arm;United States National Institutes of Health;usual care arm;virtual;Weight;weight loss intervention;weight loss program;Weight maintenance regimen;Woman;women's diagnosis

PROJECT_TITLE: Planning grant for Take Off Pounds Sensibly (TOPS) for African American (AA) Cancer Survivors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (M1)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: This project has important public health implications because preterm birth affects approximately 1 in 10 infants worldwide, and preterm children face neurodevelopmental impairments, including listening difficulty (LiD). Elucidating the mechanisms and clinical antecedents of LiD will enable targeted therapies and early identification of those at risk, thereby improving neurodevelopmental outcomes and reducing the public health burden associated with preterm birth. By enhancing our understanding of this common communication disorder associated with preterm birth, this research will help improve neurodevelopmental outcomes and aligns with the mission to understand the pathogenesis of communication disorders and develop effective interventions.

PI_NAMEs: KOJIMA, KATSUAKI  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 8 year old;Address;Affect;Age;aged;Audiology;Auditory;behavior test;Behavioral;brain abnormalities;brain magnetic resonance imaging;Caregivers;Caring;Child;Clinical;Clinical Data;cohort;Communication impairment;Comprehension;Cues;Data;design;Disease;distraction;Early identification;Early Intervention;Educational Intervention;effective intervention;Elements;Evaluation;Event;extreme prematurity;Face;Frequencies;Future;General Population;Goals;Hearing Aids;Hearing problem;Hearing Tests;high risk;high risk infant;High-Frequency Hearing Loss;Impairment;improved;Incidence;individualized medicine;Infant;Language Development;Language Disorders;language impairment;language outcome;Linear Regressions;Magnetic Resonance Imaging;Magnetoencephalography;Methods;Mission;Modeling;Monitor;National Institute on Deafness and Other Communication Disorders;Neonatal;neural;Neurodevelopmental Impairment;neuroimaging;neuromechanism;neuroprotection;Neuropsychology;novel strategies;Otitis Media;ototoxicity;Outcome;Pathogenesis;Perinatal;Pharmaceutical Preparations;Phase;Pregnancy;Premature Birth;Premature Infant;prevent;Prevention;prospective;Prospective cohort;Public Health;Questionnaires;Recording of previous events;Research;Risk;Risk Factors;Role;School-Age Population;Sensory impairment;skills;social;Social status;socioeconomics;spatial integration;Speech;speech processing;stem;targeted treatment;Testing;Therapeutic Intervention;Training;Work

PROJECT_TITLE: Uncovering the Neural Mechanisms and Antecedent Factors of Listening Difficulty in Preterm Children

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Prevention;Primary Health Care;Rare Diseases;Social Determinants of Health;Tuberculosis

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: Project narrative Globally, over 58 million pulmonary tuberculosis (TB) survivors are at a high risk of developing chronic lung disease that leads to early death and an impaired health-related quality of life. Addressing the important gap for post-TB lung disease in TB endemic areas where respiratory symptoms are often attributed to recurrent TB infection is the central aim of this proposal. We will develop and test a clinical algorithm for timely diagnosis of post-TB lung disease in Uganda with an ultimate goal of improving the care of TB survivors worldwide.

PI_NAMEs: NUWAGIRA, EDWIN  (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acceleration;acceptability and feasibility;active method;Acute;Address;Adult;Africa South of the Sahara;Age;Algorithms;Ambulatory Care Facilities;American;Applications Grants;Area;Attitude;Award;Awareness;Biological;Biometry;career;Caring;Cessation of life;Characteristics;Chest;Chronic lung disease;chronic respiratory disease;Clinic;Clinical;clinical diagnostics;clinical predictors;Clinical Trials Design;cohort;Communicable Diseases;Consensus;Cross-Sectional Studies;Data;Data Set;design;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic criteria;Diagnostic Procedure;diagnostic screening;diagnostic strategy;diagnostic tool;disability-adjusted life years;disease diagnosis;disease diagnostic;Educational Activities;effective therapy;effectiveness trial;Ensure;epidemiology study;Exercise;experience;feasibility testing;Fellowship;follow-up;Gatekeeping;Goals;Government;Grant;Guidelines;Health;Health care facility;health care settings;Health Personnel;health related quality of life;high risk;Hospital Referrals;Hospitals;Impaired health;Impairment;improved;Infection;Intervention;Intervention Studies;Interview;Knowledge;Laboratories;Literature;Longitudinal cohort;Low income;Lung Diseases;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;Multi-Drug Resistance;multidisciplinary;multiple chronic conditions;Obstructive Lung Diseases;Outcome;Outpatients;Output;Participant;Patients;person centered;Pharmaceutical Preparations;Physicians;Positioning Attribute;post intervention;practice setting;Predisposition;Prevention;Primary Health Care;Probability;programs;Protocols documentation;provider-level barriers;Public Health;pulmonary function decline;Pulmonary Tuberculosis;Qualitative Methods;Qualitative Research;Quality of Care;Quality of life;radiological imaging;randomized, clinical trials;Recommendation;Recording of previous events;recruit;Recurrence;Relapse;Research;Research Methodology;Research Personnel;Research Training;Resource-limited setting;Resources;Respiratory Disease;Respiratory Signs and Symptoms;Risk;Risk Factors;Sample Size;Sampling;scale up;Scientist;screening;Screening procedure;skills;Societies;sociodemographics;Spirometry;Sputum;success;Survivors;Symptoms;Testing;Therapeutic;Thoracic Radiography;Time;Training;Training Programs;Tuberculosis;tuberculosis treatment;Uganda;United States National Institutes of Health;Walking;Work

PROJECT_TITLE: Improving Diagnostic Strategies for Post-Tuberculosis Lung Disease in Ugandan Primary Healthcare Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICP-P (55)]


NIH_SPENDING_CATS: Chronic Pain;Fibromyalgia;Neurosciences;Pain Research;Women's Health Research

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Recent key studies have demonstrated that immune dysregulation is a defining component of fibromyalgia and chronic muscle pain. The goal of this proposal is to assess the mechanisms by which immunometabolism differentially contributes to chronic muscle pain in male and female mice. Understanding the metabolic processes underlying female-biased mechanisms will bolster research efforts in the development of novel targeted therapeutics for the alleviation of muscle pain.

PI_NAMEs: LENERT, MELISSA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Acute;adaptive immunity;Adolescent;Affect;American;Anti-Inflammatory Agents;Automobile Driving;Award;Back;Behavior;Behavioral;Bioinformatics;Biological Assay;Cells;Cellular Metabolic Process;Chronic;chronic musculoskeletal pain;chronic pain;chronic pain patient;Clinical;Clinical assessments;Clinical Data;Clinical Immunology;Clinical Research;Communication;Computational Biology;Computing Methodologies;cytokine;Data;Data Set;design;Development;Disproportionately impacts women;Estrous Cycle;Excision;Experimental Designs;Faculty;Female;Fibromyalgia;fibromyalgia patients;Flow Cytometry;follow-up;Functional disorder;Goals;Gonadal Steroid Hormones;High Fat Diet;Immune;immunocytochemistry;Immunology;improved;Inflammation;Inflammatory;Institution;Intervention;Intramuscular Injections;Journals;Literature;Maintenance;male;Measurement;Mediating;Mentors;Mentorship;Metabolic;Metabolism;Molecular Biology;monocyte;mouse model;Movement;Mus;muscle strength;Myalgia;Neuroendocrinology;neuroimaging;Neuroimmune;Neurosciences;Neurosecretory Systems;new therapeutic target;novel;Oral;Output;Pain;pain behavior;Pain Measurement;pain outcome;pain processing;pain signal;patient population;Patient-Focused Outcomes;Patients;Peripheral;Phase;Phenotype;Phosphotransferases;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-clinical assessment;Pre-Clinical Model;Preparation;Prevalence;Price;profiles in patients;Publishing;Quality of life;Research;Research Personnel;Research Project Grants;Rheumatism;Role;Saline;Scientist;sex;Sex Bias;Sex Differences;sexual dimorphism;Signal Transduction;skills;spontaneous pain;statistics;STK11 gene;symposium;Symptoms;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;translating ribosome affinity purification and RNA-sequencing;translational approach;Translational Research;Woman;Work;Writing

PROJECT_TITLE: Identification of Sex Differences in Monocytes and Metabolism in the Maintenance of Chronic Muscle Pain


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE The evolutionary and mechanistic relationship between spatial and abstract cognition remains understudied and elusive. Prior research addressing this connection has relied on limited methodology in a small number of primate subjects, despite the reality that rodent models possess excellent spatial and abstract abilities and are much more suitable for precise neural manipulation. My pre- and postdoctoral research will take a comparative approach towards investigating the neural mechanisms of higher order cognition where I will 1) utilize chemogenetic tools to manipulate rodent neural activity, and 2) expand my technical training, potentially including in vivo recording in primates and computational approaches – providing me with the intellectual, technical, and professional skills necessary to successfully pursue an independent career in comparative behavioral neuroscience at an academic research institution.

PI_NAMEs: WISE, TAYLOR BLAINE (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Affect;Amygdaloid structure;Area;Arousal;Auditory;auditory stimulus;Automobile Driving;base;Behavior;Behavioral;Behavioral Paradigm;Brain;brain computer interface;Brain region;career;Cognition;Communication;comparative;Complex;conditioning;Data;design;Disease;Ecology;Environment;Environmental Risk Factor;Exhibits;Face Processing;Facial Expression;fly;Future;gaze;Genetic;in vivo;indexing;insight;Institution;Investigation;Knowledge;Left;Macaca;Machine Learning;Methodology;Methods;Monkeys;Motivation;Mus;neural;neuromechanism;Neurosciences;nonhuman primate;novel;Pattern;Perception;Postdoctoral Fellow;pre-doctoral;preference;Primates;Research;Rodent;Rodent Model;skills;social;social attention;Social Behavior;social bias;social cognition;social deficits;social engagement;social influence;Social Interaction;social interventions;Social Perception;Stimulus;Techniques;Time;tool;Training;Visual;visual information;visual stimulus;Work

PROJECT_TITLE: Neural Bases of Internal States Driving Social Attention and Perception


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Childhood Injury;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Transplantation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Due to the similarities between pig and human brain anatomy, development, and neuroinflammatory response, pigs are a highly promising model for studying age-specific responses to mechanical trauma. Here we have developed a training plan where I will use a battery of multiparametric behavioral and physiological assessments to characterize post-injury changes in a pig model of pediatric concussion. The findings from these studies could encourage researchers to use the pig to develop novel therapies for use in neurotrauma patients, and ultimately improve diagnostics and prognostication on the front lines of TBI patient care.

PI_NAMEs: NETZLEY, ALESA HUGHSON (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Adolescent;Adult;age related;Anatomy;Animal Model;Animals;Architecture;Area;Assessment tool;Attention;Autopsy;Behavior;Behavior assessment;behavior test;Behavioral;bench to bedside;Biological;Biological Markers;biomarker identification;Brain;Brain Concussion;Brain Injuries;care outcomes;career;Cause of Death;Cell Transplantation;Child;Childhood;Clinical;Clinical Research;clinically relevant;Closed head injuries;Cognition;cognitive function;computerized data processing;Craniocerebral Trauma;Data;Demyelinations;design;Development;Devices;Diagnosis;Diagnostic;Diffuse;disability;Disease;Domestic Pig;Early identification;Effectiveness;efficacy evaluation;efficacy validation;Electrophysiology (science);Emergency department visit;Exhibits;experience;Faculty;Family suidae;Functional disorder;Functional Magnetic Resonance Imaging;Future;Goals;head impact;Health;Histologic;Hour;Human;Imaging Techniques;Impaired cognition;improved;improved outcome;Individual;Injury;interest;Ischemic Stroke;Learning;Long-Term Potentiation;Magnetic Resonance Imaging;Measures;Mechanics;member;Mental Depression;Mentors;mild traumatic brain injury;Miniature Swine;Modeling;Molecular;mouse model;multimodality;Natural regeneration;nerve injury;nerve stem cell;Nervous System Trauma;neural;Neurocognitive;neuroimaging;neuroinflammation;Neurons;nonhuman primate;novel;novel therapeutic intervention;novel therapeutics;Organism;Patient Care;Patient-Focused Outcomes;Patients;pediatric patients;Phase;Physiological;Physiology;porcine model;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-clinical;Procedures;prognostication;Public Health;Publishing;Rattus;Recovery;Rehabilitation therapy;Reproducibility;Research;Research Personnel;response;Rodent;Rodent Model;sham surgery;skills;Sleep disturbances;Stem cell transplant;stroke model;Structure;Study models;System;TBI Patients;Techniques;Teenagers;Therapeutic;Tissues;Training;Translating;translational neuroscience;Translational Research;transplantation therapy;Trauma;Traumatic Brain Injury;United States;white matter;Work

PROJECT_TITLE: Assessing the efficacy of NIR therapy to modulate shared secondary injury mechanisms in a murine model of ischemic stroke and porcine model of TBI


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative  Optical coherence tomography angiography (OCTA) allows measurement of vessel density in the retina that provides novel information on retinal microvasculature associated with the development and worsening of glaucoma in a racially diverse cohort. We propose to improve detection and prediction of glaucomatous progression by disassociating age-related changes in OCTA measurements from glaucoma-related changes, by employing deep-learning analyses and by modifying predictive models by adding OCTA measurements. Enhanced detection of progression should lead to earlier and more effective treatment, thus reducing the rate of disease worsening and preventing loss of vision-related quality of life (including blindness).

PI_NAMEs: WEINREB, ROBERT N (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;Age;age related changes;Angiography;Area;Blindness;Blood Vessels;Classification;Clinical;clinical imaging;cohort;Data;deep learning;density;Detection;Development;Diagnosis;diagnostic accuracy;Disease;Disease Progression;effective therapy;Eye;Eye diseases;Functional disorder;Glaucoma;Image;imaging modality;improved;Individual;instrument;Laboratories;Longitudinal Studies;Machine Learning;macula;Measurement;Measures;Monitor;multimodality;novel;Open-Angle Glaucoma;Optic Disk;Optical Coherence Tomography;Patients;predictive modeling;prevent;Quality of life;racial diversity;rate of change;Research;Retina;retina blood vessel structure;retinal nerve fiber layer;Risk;Risk Reduction;Scotoma;Severity of illness;statistical learning;Suspect Glaucomas;Thick;Time;Tissues;Visual impairment;Visualization

PROJECT_TITLE: Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography Angiography

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(81)-S]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE After a stroke, individuals with sensory impairments have high instances of balance problems, falls, and lower extremity dysfunction, implicating the role of sensorimotor reorganization (i.e., plasticity). Here, we take an initial step in characterizing post-stroke sensorimotor plasticity and its relationship to walking using paired associative stimulation. The proposed work will lay the foundation for a career in which I aim to better inform lower extremity rehabilitation efforts by providing functional biomarkers as targets for modulation, and structural neural correlates to improve prognoses.

PI_NAMEs: CASH, JASMINE JAMILAH (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Academic Medical Centers;Activities of Daily Living;Address;Award;balance recovery;Behavior;Biological Assay;Biological Markers;brain health;Brain Stem;career;career development;Central Nervous System;Clinical;Communication;Complex;conventional therapy;Corticospinal Tracts;Diffusion;Effectiveness;Electric Stimulation;Electroencephalography;Electrophysiology (science);equilibration disorder;Equilibrium;Exhibits;experience;fall risk;falls;Feedback;Foundations;Functional disorder;functional independence;Functional Magnetic Resonance Imaging;Goals;high risk;Hypesthesia;Image;Impairment;improved;independent ambulation;Individual;Individual Differences;interest;Investigation;Knowledge;Learning;Lower Extremity;Measures;Mediating;Mediator;Mentors;Mentorship;method development;Methods;Motor;Motor Cortex;Motor Evoked Potentials;Motor output;multimodality;Muscle;Nervous System;neural;neural correlate;neuroimaging;Neuronal Plasticity;neurophysiology;neuroregulation;novel;Obesity;Outcome;Performance;Phase;post stroke;Postdoctoral Fellow;postsynaptic neurons;pre-doctoral;presynaptic neurons;Process;Prognosis;Protocols documentation;Quality of life;Recovery;Rehabilitation therapy;Research;Research Personnel;Research Training;response;Role;Route;Sensory;sensory cortex;Sensory impairment;sensory input;sensory integration;Shapes;Signal Transduction;skills;Somatosensory Cortex;Somatosensory Evoked Potentials;spasticity;Spinal Cord;Stimulus;Stroke;stroke recovery;stroke survivor;Structure;Synapses;System;Techniques;Time;Training;Transcranial magnetic stimulation;Translations;treatment response;Upper Extremity;Walking;Work

PROJECT_TITLE: The Effects of Obesity on Limiting Brain Health and Stroke Recovery

STUDY_SECTION: NST

STUDY_SECTION_NAME: Neurological Sciences Training 3 Study Section[NST-3]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Despite the clear link between type 1 diabetes (T1D), decreases in brain structures and functions, and challenges with mental flexibility, intelligence, memory, executive functioning, and processing speed, studies focused on neuroimaging and neurocognition in the context of T1D biomarkers; social determinants of health; sleep; diabetes technologies; academic achievement; and psychological, social, and school functioning in children with new-onset T1D in the United States are extremely sparse. Therefore, there is an urgent need to address these gaps in the extant literature to identify opportunities to prevent or mitigate cognitive challenges for individuals with T1D across the lifespan. The overarching goals of the Diabetes Brain and Cognitive Development – Type 1 Diabetes (DBCD-T1) study are consistent with NIDDK’s desire to understand neurocognitive complications of pediatric type 1 diabetes and the role of risk and protective factors.

PI_NAMEs: DRISCOLL, KIMBERLY  (contact);GURKA, MATTHEW JAMES;SCHATZ, DESMOND ARTHUR;ZIELINSKI, BRANDON A.

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Academic achievement;actigraphy;Address;Adult;Age;Age of Onset;American;Anxiety;Area;Attention;Autoantibodies;Behavior;Beta Cell;Biologic Characteristic;Biological;Biological Markers;Biological Process;Biometry;Blood Glucose;Bolus Infusion;Brain;Brain imaging;brain volume;C-Peptide;Carbohydrates;caregiver education;Caregivers;Cell Physiology;Cerebellum;Characteristics;Child;Childhood;Clinical;clinical center;Cognition;Cognitive;cognitive ability;cognitive development;cognitive performance;Collection;community advisory board;community engagement;community science;Conflict (Psychology);Consult;Continuous Glucose Monitor;coping;Data;dementia risk;demographics;density;Development;Devices;Diabetes autoantibodies;diabetes distress;Diabetes Mellitus;diabetes self-management;Diabetic Ketoacidosis;early childhood;Energy-Generating Resources;executive function;experience;Family;flexibility;Florida;Frequencies;Fright;frontal lobe;General Population;Genetic Risk;Glucose;glucose metabolism;glucose monitor;Glycosylated hemoglobin A;Goals;gray matter;Growth;Healthcare;Hippocampus;Hormones;Household;human old age (65+);Hyperglycemia;Hypoglycemia;imaging study;Impaired cognition;inattention;Income;Individual;Insulin;insulin dependent diabetes mellitus onset;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Insurance Coverage;Intelligence;Language;Length;Life;life span;Link;Literature;Mathematics;Measurement;Medicine;Memory;Mental Depression;Motor Skills;National Institute of Diabetes and Digestive and Kidney Diseases;Neurocognition;Neurocognitive;neurocognitive test;neurodevelopment;neuroimaging;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;Occipital lobe;older adult;Outcome;Pancreas;Parietal Lobe;Participant;Population;prevent;prisma;processing speed;Program Evaluation;protective factors;Psyche structure;psychologic;Psychology;psychosocial;Quality of life;Questionnaires;Reading;real time monitoring;Recommendation;recruit;Research Design;Residual state;resilience;Risk Factors;Role;rural counties;Schools;Science;screening;Severities;sex;Site;skills;Sleep;social;social health determinants;social structure;sociodemographics;Standardization;Stress;Structure;success;Syringes;Technology;Temporal Lobe;Testing;Thalamic structure;Time;United States;Universities;Variant;verbal;white matter;Writing

PROJECT_TITLE: Diabetes Brain and Cognitive Development-Type 1 (DBCD-T1)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M3)]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Microglia, immune cells in the brain, address alterations in brain function and disease using selective signaling pathways. One of these pathways—the calcium pathway—becomes very active during epilepsy development, but its purpose is not well understood. By determining the function of this calcium pathway, we can establish its potential for therapeutic value and advance basic knowledge of its role in the disease process.

PI_NAMEs: UMPIERRE, ANTHONY DAVID (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Address;Affect;Anesthesia procedures;Animals;Area;Automobile Driving;awake;Benchmarking;Brain;Calcium;Calcium Signaling;Calcium-Sensing Receptors;Cells;Cellular Morphology;Central Nervous System;Clinic;Cognition;Complex;confocal imaging;cytokine;Cytoskeleton;Development;Disease;Electroencephalography;Epilepsy;Epileptogenesis;excitotoxicity;experience;Genetic Transcription;Goals;GTP-Binding Proteins;Hippocampus;Histology;Image;Immune;in vivo;Induced Neurons;Inflammation;Inflammatory;innovation;insight;Internal Ribosome Entry Site;kainate;Knock-out;Knockout Mice;Knowledge;lens;Link;Lysosomes;Metabolic Clearance Rate;Microglia;Microscope;miniaturize;Modeling;Morphology;Motility;Movement;Mus;National Institute of Neurological Disorders and Stroke;network dysfunction;Neuroglia;neuronal circuitry;Neurons;next generation sequencing;novel;optogenetics;Pathway interactions;Phagocytes;Phagocytosis;prevent;Process;protective effect;Purines;Purinoceptor;purinoceptor P2Y6;Receptor Signaling;Research;Rest;Risk;Risk Reduction;Role;Seizures;Signal Pathway;Signal Transduction;Signaling Protein;Source;Status Epilepticus;Supervision;Techniques;Technology;Testing;Therapeutic;Time;tissue fixing;Tissues;Training;two photon microscopy;two-photon;Visualization

PROJECT_TITLE: Microglial P2Y6 receptor calcium signaling as a core regulator of epileptogenesis

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative The study aims to delineate targeted brain mechanisms that contribute to the speech processing difficulties underlying key aspects of social communication impairments in autism spectrum disorder (ASD). We utilize innovative encephalography methods to test the hypothesis that context-dependent auditory processing, i.e., the brain’s ability to fine-tune auditory signals based on prior predictions, is disrupted in ASD across levels of the neural auditory pathway. The extent to which disrupted context-dependent auditory processing contributes to key clinical- behavioral speech and social language phenotypes of ASD will be tested.

PI_NAMEs: LAU, CHUNG YIN JOSEPH  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Acoustics;Auditory;auditory pathway;auditory processing;autism spectrum disorder;autistic;base;Behavioral;Biological;Biological Markers;Brain;brain behavior;Clinical;clinical translation;clinically relevant;Communication;Communication difficulty;comparison control;Complex;Cueing for speech;Data;Development;Electroencephalography;Elements;Emotional;encephalography;Environment;Equilibrium;Esthesia;Etiology;expectation;experience;Factor Analysis;Feedback;Foundations;Frequencies;Friendships;Future;Hearing;Homeostasis;improved;Individual;individuals with autism spectrum disorder;innovation;insight;Intervention;Language;Linguistics;Literature;Measures;Methods;neural;neuromechanism;Neurosciences;Noise;novel;Pattern;Perception;Phenotype;phrases;Play;Process;Quality of life;Recording of previous events;response;Role;Sampling;Sensory;Signal Transduction;skills;social;social communication;social communication impairment;social interventions;sound;Speech;speech in noise;Speech Perception;speech processing;Speech Sound;Stimulus;System;Techniques;Testing;Theoretical model;theories;tool;Translational Research;Workplace

PROJECT_TITLE: The Role of Context in the Neural Processing of Speech in Autism Spectrum Disorder


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Hematology;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative With advancing age, many people develop mutant clones of blood cells that circulate throughout their body. Surprisingly, having such clones associates with protection against Alzheimer’s disease and some of these mutant cells are able to engraft in the brain. Here, we will use genetic data and brain samples from large cohorts and established brain banks to uncover how these mutant cells provide protection against Alzheimer’s.

PI_NAMEs: BENDALL, SEAN CURTIS;JAISWAL, SIDDHARTHA  (contact);KEENE, CHRISTOPHER DIRK;MONTINE, THOMAS J

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Acute Myelocytic Leukemia;aged;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer's disease therapy;ATAC-seq;Atherosclerosis;biobank;Biological;Biological Assay;Blood;Blood Cells;Brain;Brain imaging;Brain region;brain tissue;Cell Nucleus;Cells;chromosome Y loss;chronic inflammatory disease;clinically relevant;Clonal Expansion;cohort;Data;Dementia;density;Development;Disease;DNMT3a;Elderly;Engraftment;Epidemiology;epidemiology study;Epigenetic Process;Functional disorder;Gene Expression;Gene Expression Profile;Genes;Genetic;genomic data;Germ Lines;Goals;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;high dimensionality;Hippocampus;Human;Image;Immune;Immunohistochemistry;In Situ;Infiltration;Inherited;innovation;Lead;Lesion;Link;Macrophage;Mediating;Medicine;Methods;Microglia;Molecular;Mosaicism;multiplexed imaging;mutant;Mutate;Mutation;Myeloid Cells;Nature;neuropathology;novel;novel therapeutics;Organ;Outcome;Outcomes Research;Pathogenesis;Pathway interactions;Persons;Phagocytosis;Phenotype;Physiology;Play;Prefrontal Cortex;prevent;programs;Proliferating;promote resilience;Property;Research;Research Proposals;resilience;Risk;Role;Sample Size;Sampling;senescence;senescent cell;single cell genomics;single nucleus RNA-sequencing;stem cells;Stress;Surveys;Testing;Time;tissue stem cells;Variant;Work

PROJECT_TITLE: Uncovering mechanisms of protection from Alzheimer's disease in CHIP using human cohorts and biosamples

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-I (M3)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Neuronal calcium dysregulation has been linked to numerous neurological and neurodegenerative disorders including Alzheimer’s Disease, Parkinson Disease, and Autism. This proposal will employ innovative imaging approaches and precise casual manipulations, including a novel optogenetic tool, to test the role of the endoplasmic reticulum calcium store in brain function and learning & memory. In so doing, this work may shed light on the mechanism(s) by which neuronal calcium contributes to neurodegenerative disease.

PI_NAMEs: O'HARE, JUSTIN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, KARI ANNE

PROJECT_TERMS: Action Potentials;Address;Alzheimer's Disease;Animals;Apical;Area;autism spectrum disorder;Automobile Driving;awake;Behavior;Behavioral;Biophysics;Brain;BRAIN initiative;Calcium;career development;Cells;cellular imaging;Color;Communities;Dendrites;Development Plans;Electroporation;Endoplasmic Reticulum;Environment;Equipment;experience;experimental study;Fire - disasters;Foundations;gain of function;Genetic;Glutamates;Goals;Head;hippocampal pyramidal neuron;Hippocampus;Image;imaging approach;Imaging Techniques;improved;In Vitro;in vivo;innovation;insight;Intervention;Investigation;Knowledge;Laboratories;Learning;Light;Link;Literature;Logic;Memory;Mentorship;Mission;Molecular;Molecular Genetics;Monitor;Morphology;Mus;Nervous System Disorder;neural;Neurodegenerative Disorders;neuronal cell body;Neuronal Plasticity;Neurons;Neurosciences;new technology;novel;optogenetics;Output;Parkinson Disease;Pathway interactions;Pattern;pharmacologic;Pharmacology;place fields;Play;post-doctoral training;Postdoctoral Fellow;postsynaptic;presynaptic;Prevalence;receptive field;Reporter;Reporting;Research;Research Activity;Resource Development;Role;Shapes;spatiotemporal;subcellular targeting;Synapses;Synaptic plasticity;Testing;tool;two-photon;virtual environment;virtual reality;way finding;Work

PROJECT_TITLE: Defining the Circuit, Synaptic, and Molecular Mechanisms Linking Intracellular Ca2+ Release to Learning Using Subcellularly-Targeted Manipulations and Imaging Techniques in Dendrites in Vivo


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative More than 20% of individuals over 70 have a mutant blood clone that increases risk of multiple aging diseases. We will use data from 1.5 million people to identify resiliency mechanisms that modify this blood clone expansion including genetics, circulating proteins, vitamins, and medications. This research will improve our knowledge about how to risk stratify and modify risk of aging diseases in individuals with mutant blood clones.

PI_NAMEs: BICK, ALEXANDER  (contact);JAISWAL, SIDDHARTHA ;MAJETI, RAVINDRA

PROJECT_TERMS: Address;adverse outcome;Affect;Age;Aging;aging mechanism;aging population;aging related disease;Ascorbic Acid;biobank;Biological Assay;Biological Models;Birth;Blood;blood fractionation;Blood specimen;Cardiovascular Diseases;Cells;Centenarian;Chromosome abnormality;Clonal Expansion;cohort;Collection;Computing Methodologies;Critical Pathways;cytokine;Data;Data Set;defined contribution;Dementia;detection limit;Development;Disease;Disease Outcome;disorder risk;DNA;DNA Sequence Alteration;epidemiology study;Experimental Hematology;functional decline;Genes;Genetic;genetic association;genetic epidemiology;genetic variant;Genome;genome-wide;Genomic approach;genomic data;Genomics;Germ-Line Mutation;Growth;Health;Hematopoiesis;Hematopoietic stem cells;high risk;Human;human genomics;human old age (65+);improved;In Vitro;in vivo;in vivo Model;Incidence;Individual;individualized prevention;Infection;infection risk;Inherited;insight;Kidney Diseases;Knowledge;life span;lifestyle intervention;Link;Liver diseases;Loss of Heterozygosity;Malignant Neoplasms;metabolomics;Modeling;molecular modeling;mortality;mosaic;Mosaicism;multidisciplinary;mutant;Mutation;National Heart, Lung, and Blood Institute;Nature;Nervous System Disorder;novel;Participant;Persons;Pharmaceutical Preparations;Phenotype;Plasma;Point Mutation;poor health outcome;Population;Predictive Factor;preventive intervention;Process;programs;promoter;Proteins;Proteomics;rare variant;Research;resilience;resilience in aging;Resistance;Respiratory Disease;Risk;risk stratification;Role;Sampling;Scientific Advances and Accomplishments;Somatic Mutation;Stroke;Surveys;System;targeted sequencing;targeted treatment;Testing;therapeutic development;therapy development;Time;Tissues;Trans-Omics for Precision Medicine;United States National Institutes of Health;Vitamins;whole genome;Work;young adult

PROJECT_TITLE: Clonal Hematopoiesis Aging Resiliency Mechanisms


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PROVO

ORG_DEPT: PHYSICS

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: Project Narrative In this project, we aim to combine advanced computer algorithms and fast experimental tests to develop improved proteins for medical purposes. By merging the power of artificial intelligence and physics-based simulations, we seek to speed up the process of designing enzymes that are both stable and functional. Specifically, we will focus on enhancing the diagnostic protein NanoLuc and the potential cancer treatment Onconase, paving the way for more effective and precise medical applications.

PI_NAMEs: DELLA CORTE, DENNIS  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Active Sites;American;Amino Acid Sequence;Artificial Intelligence;artificial intelligence model;Award;Base Sequence;Biological Assay;cancer immunotherapy;cancer therapy;career;Cells;clinical diagnostics;Computational algorithm;cost;design;design,build,test;Diagnostic;Education;Engineering;Enzyme Stability;Enzymes;Evolution;experience;experimental study;Faculty;Free Energy;glucose monitor;Goals;graduate student;Health;Healthcare;heuristics;improved;Industry;Injections;Institution;Insulin;Learning;Life;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;machine learning prediction algorithm;Malignant Neoplasms;Medical;Medicine;Methods;Modeling;Molecular Conformation;Movement;Mutation;Neural Network Simulation;next generation;Onconase;Persons;Physics;Process;Protein Biosynthesis;Protein Engineering;protein folding;protein structure prediction;Proteins;rational design;Reaction;Reporter;Research;Research Personnel;simulation;Speed;Structure;Students;Technology;Testing;Therapeutic;therapeutic protein;tool;Training;undergraduate student;Validation

PROJECT_TITLE: Engineering Enzymes for Improved Stability and Retained Function via Rapid Design-Build-Test-Learn Cycles integrating AI/Physics based predictions with Cell-free Protein Synthesis Experimental Testing

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE The activation of proton-activated chloride channel (PAC) is one of the key factors that determines the severity of brain damage after ischemic stroke. The proposed study aims to elucidate the working mechanism of how PAC senses environmental pH and its pharmacological properties. This knowledge will serve as a foundation to develop novel treatment strategies for ischemic stroke and other diseases that are associated with tissue acidosis.

PI_NAMEs: RUAN, ZHENG  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Acidosis;Acids;Adopted;Anions;Antibodies;Antibody Formation;Architecture;Award;Benzoic Acids;Binding;Binding Sites;Biochemical;Brain;Brain Injuries;Cell Death Induction;Cell Line;Cells;Cerebrum;Cessation of life;channel blockers;Chloride Channels;Chlorides;Computing Methodologies;Cryoelectron Microscopy;design;Development;disability;Disease;effective therapy;Electrophysiology (science);experimental study;extracellular;Extracellular Domain;Foundations;Future;Genes;Goals;Human;Immunize;improved;inhibitor;Injury;insight;Intervention;Investigation;Ions;Ischemic Stroke;Knowledge;Link;Lipids;Mediating;Membrane Proteins;Mentors;Metabolic;Molecular;Molecular Conformation;Monoclonal Antibodies;Mouse Protein;Mus;mutant;Mutation;nanodisk;Neurons;neurotoxicity;Niflumic Acid;novel;Orthologous Gene;Outcome;particle;patch clamp;Pathologic;Pathologic Processes;Pathway interactions;Patients;pharmacologic;Pharmacologic Substance;Phase;Physiological;Play;Post-Translational Protein Processing;Postdoctoral Fellow;pregnenolone sulfate;Probability;Procedures;Property;protein purification;protein structure;Proteins;Protons;Recombinants;Research;Research Personnel;response;Rest;RNA Splicing;Role;screening;sensor;Services;Severities;small molecule;Solid;stoichiometry;Structure;Supervision;Swelling;System;Techniques;Therapeutic;Time;Tissues;Titrations;Toxic effect;Training;treatment strategy;United States;Variant;voltage;Work

PROJECT_TITLE: Structural and Functional Studies on Proton-activated Chloride (PAC) Channel


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Neurosciences;Sexually Transmitted Infections

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Herpes simplex virus (HSV) persists for life in neurons as a latent infection and can reactivate to cause disease. The aims of this study are to develop and fully characterize a new model of HSV latent infection in human sensory neurons, along with testing the ability of a clinically relevant compound to prevent reactivation. This new model will be an easily scalable system in a relevant human neuronal type that can be used to investigate the mechanisms of HSV latency and reactivation, and ultimately permit the identification of new therapeutic targets.

PI_NAMEs: CLIFFE, ANNA RUTH (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Afferent Neurons;American;Anti-viral Agents;Attention;Biological Models;Body Surface;Cell Line;cell type;Cells;Cellular Stress;Chromatin;clinically relevant;Cutaneous;Data;Development;differentiation protocol;Disadvantaged;Disease;Encephalitis;Epigenetic Process;fetal;Gene Expression;genital herpes;genital infection;Genome;Goals;Heat Stress;Herpesvirus 1;Heterochromatin;Histones;Human;Human Cell Line;human pathogen;improved;In Vitro;in vitro Model;Infection;inhibitor;Interruption;Keratitis;Late Onset Alzheimer Disease;latency associated transcript;latent infection;Latent virus infection phase;Lesion;Life;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Nature;neonate;Nerve Growth Factor Receptors;Nerve Growth Factors;neuron development;Neuronal Differentiation;Neurons;neurotrophic factor;new therapeutic target;novel;novel therapeutics;Pain;Pathway interactions;Peripheral;Phase;Post-Translational Protein Processing;prevent;Production;reactivation from latency;receptor;recombinant virus;Recombinants;Refractory;response;Risk;Role;Sexual Transmission;Signal Pathway;Signal Transduction;Simplexvirus;Spinal Ganglia;Stimulus;Structure;System;targeted treatment;Testing;Therapeutic;Time;tool;Toxic effect;transmission process;Viral Genes;Viral Genome;viral resistance;viral transmission;Virus;Virus Latency;Work

PROJECT_TITLE: HSV latency and reactivation in a human sensory neuronal model system

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This study aims to uncover the long-term effects of early exposure to environmental toxicants on the development of Alzheimer's Disease and related dementias (AD/ADRD), utilizing extensive, longitudinal data from the CARDIA Study. It will employ advanced techniques in exposomic, genomic, epigenomic, transcriptomic data analyses to trace the biological impact of the toxicants and understand their role in cognitive decline and changes in brain structure. The research also seeks to understand the social determinants of health that contribute to racial disparities in AD/ADRD development, striving for a comprehensive view of environmental and societal influences.

PI_NAMEs: CHEN, AIMIN  (contact);HOU, LIFANG ;JONES, DEAN PAUL;YAFFE, KRISTINE

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;Affect;African American;Age;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Artificial Intelligence;Biological;Biological Assay;Biological Markers;Biological Process;biracial;Black Populations;Black race;Blood;Brain;brain magnetic resonance imaging;Cadmium;Cerebrovascular Circulation;chemical association;Chemicals;Chlorinated Hydrocarbons;Cities;Clinical;Cognition;cognitive change;cognitive function;cohort;Cohort Studies;Communities;Coronary Artery Risk Development in Young Adults Study;Coupled;Data;Data Analyses;dementia risk;Development;dichlorodiphenyltrichloroethane;Discrimination;Disease;DNA Methylation;Education;Enrollment;environmental chemical;Environmental Exposure;Environmental Impact;Environmental Risk Factor;epigenetic marker;Epigenetic Process;epigenomics;Exposure to;follow-up;Funding;Future;Genetic;genome sequencing;Genomics;health disparity;Heavy Metals;High Prevalence;Impaired cognition;individualized prevention;insight;Joints;Laboratories;Lead;Life;Link;Long-Term Effects;machine learning method;Magnetic Resonance Imaging;Maps;Measures;Mediating;Mediation;Mendelian randomization;Metals;middle age;Modification;multiple omics;National Heart, Lung, and Blood Institute;Nerve Degeneration;neuroimaging;neuroinflammation;neurotoxic;novel;older adult;organochlorine pesticide;Organophosphates;Oxidative Stress;Participant;Pathogenesis;Pathway interactions;Pattern;persistent organic pollutants;Persons;Pesticides;Plasma;polybrominated diphenyl ether;Polychlorinated Biphenyls;Poverty;pre-clinical;Prevalence;Process;programs;Property;racial difference;racial disparity;recruit;Request for Applications;Research;Risk;Role;Sampling;screening;sex;social health determinants;Structure;Symptoms;systemic inflammatory response;Techniques;Thick;Time;Toxic Environmental Substances;toxicant;Toxicant exposure;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;Urine;white matter;whole genome;young adult

PROJECT_TITLE: Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIA


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Gene Therapy;Genetics;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: VILLANOVA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VILLANOVA UNIVERSITY

PHR: PROJECT NARRATIVE Current cell therapies use a lentivirus to effectively deliver therapeutic genes to T cells and HSCs, but this strategy can be expensive and potentially hazardous. The goal of this project is to optimize the non-viral delivery, integration, and expression of genes in T cells and HSCs to provide a safer and less expensive alternative to viral gene delivery. Eighteen undergraduate students will be recruited to participate in this project as part of Villanova’s Senior Project Studio (a 2-semester research for credit course), while the PIs will also use the data and methods developed in this project to develop group projects and other learning experiences for dozens of other students in their lecture and lab courses.

PI_NAMEs: ELMER, JACOB JAMES (contact);HUANG, ZUYI

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adenosine deaminase deficiency;Area;Binding Sites;Biocompatible Materials;biocompatible polymer;CAR T cell therapy;carcinogenesis;Cell Nucleus;Cell Survival;Cell Therapy;cell type;Cells;cellular engineering;Charge;Chemistry;ChIP-seq;Collaborations;Complex;Data;delivery vehicle;design;Development;Disadvantaged;Drug Delivery Systems;Dysmyelopoietic Syndromes;Educational process of instructing;Environment;Epigenetic Process;epigenetic regulation;experience;experimental study;Family;Flow Cytometry;Future;Gene Activation;Gene Delivery;Gene Expression;Gene Expression Profile;gene therapy;Genes;Genome;Genomics;Goals;hands on research;Hematopoietic stem cells;Hemophilia A;histone modification;Human;Immunology;improved;in silico;In Vitro;in vivo;inhibitor;integration site;Knock-in;Knock-out;Learning;lectures;lentiviral integration;Lentivirus;Ligands;lipofection;Malignant Neoplasms;Methods;mRNA delivery;nanoparticle;nanopolymer;non-viral gene delivery;novel;novel therapeutics;nucleic acid delivery;Oncogenic;overexpression;Patients;Pattern;Polymers;Probability;Proteins;recruit;Repression;Research;Research Project Grants;screening;siRNA delivery;Site;Small Interfering RNA;small molecule inhibitor;stem cell therapy;Structure-Activity Relationship;Students;success;Surface;T-Lymphocyte;Testing;therapeutic gene;tool;Transfection;transgene expression;Transgenes;undergraduate student;uptake;viral gene delivery;Virus;Virus Inhibitors;Work

PROJECT_TITLE: Improving Non-Viral Gene Delivery, Integration, and Expression Methods for Cell Therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Clonal Hematopoiesis (CH) refers to somatic mutations that have a strong association with aging. However, the risk factors associated with CH development and the trajectory of aging- associated CH, as well as its relationship with age-related diseases are poorly understood. Through the means of this proposal, we will leverage a singular cohort enriched for exceptional longevity to comprehensively characterize CH and the role of protective longevity-related factors on disease prevalence and incidence in the presence of CH.

PI_NAMEs: MILMAN, SOFIYA ;SHASTRI, ADITI  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Age;age related;age-related disease;Aging;aging related;Alzheimer's Disease;Alzheimer's disease risk;Area;Biological;Biological Factors;Biology;Blood Cells;Cardiovascular Diseases;Centenarian;Clinical;clinical phenotype;Clonal Evolution;Clonal Hematopoietic Stem Cell;cognitive function;cohort;college;comparison control;Complex;Data;Development;Disease;DNA;DNA Methylation;Dysmyelopoietic Syndromes;Epidemiology;ethnic diversity;Exhibits;exome sequencing;Family history of;follow-up;follower of religion Jewish;frailty;Future;General Population;Genetic;genetic risk factor;genetic variant;Genotype;Germ Lines;Health;healthspan;healthy aging;Hematologic Neoplasms;Hematopoiesis;Human;Incidence;Independent Living;Individual;insight;Intervention;Investigation;Lead;life span;Literature;Longevity;longevity gene;longitudinal analysis;Longitudinal Studies;Low Prevalence;Malignant Neoplasms;Medicine;methylomics;mortality;multiple omics;Mutation;New England;Non-Insulin-Dependent Diabetes Mellitus;novel;offspring;older adult;Outcome;Parents;Pathway interactions;Pattern;Persons;Population;Population Heterogeneity;Prevalence;prospective;Protein Methylation;Proteins;Proteomics;racial diversity;Reporting;Research Proposals;resilience factor;resilience in aging;Risk;Risk Factors;Role;Sampling;sex;socioeconomics;Somatic Mutation;study population;Time;validation studies;Variant;Whole Blood

PROJECT_TITLE: CH in Aging and Exceptional Longevity