NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE APOE4 is the greatest known genetic risk factor for sporadic Alzheimer's and there exists a high unmet medical need for therapeutics that could prevent disease associated with this variant. We have developed an innovative split luciferase assay that can detect the binding of compounds to ApoE4 in cells. We propose to leverage this breakthrough to both discover new and optimize known ApoE4 correctors into drugs that can generate in vivo proof of concept that they can functionally correct ApoE4 pathobiology in murine models and ultimately be developed into a therapeutic for AD.

PI_NAMEs: JACKSON, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: Acceleration;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer's disease therapeutic;Amino Acids;Amyloid deposition;analog;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Arginine;Astrocytes;Binding;Biological;Biological Assay;Biological Markers;Biology;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier function;Brain;C-terminal;Cell model;Cells;Chemicals;Clinical Trials;Complex;Cysteine;Data;Defect;design;Disease;DNA Sequence Alteration;Dose;Drug Kinetics;effective therapy;Engineering;experimental study;Functional disorder;gain of function;Genetic;Genetic Risk;genetic risk factor;Genotype;high throughput screening;Human;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Inherited;innovation;Laboratories;Lead;Length;Libraries;Lipid Binding;Lipids;loss of function;Luciferases;Measures;Mediating;Medical;melting;Membrane;miniaturize;Modeling;mouse model;Mus;mutant;Mutation;N-terminal;nanoluciferase;Neurofibrillary Tangles;Pathway interactions;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Positioning Attribute;prevent;Property;Protein Conformation;Protein Isoforms;protein purification;Proteins;Public Health;Publishing;Recombinant Proteins;Recombinants;Relative Risks;Research;Risk;Route;scaffold;Scientist;screening;Series;small molecule;Structure;Synapses;Techniques;Testing;Therapeutic;Toxic effect;Transgenic Animals;Transgenic Mice;Transgenic Model;Transgenic Organisms;Variant

PROJECT_TITLE: Discovery and optimization of ApoE4 correctors for the treatment of Alzheimer's Disease

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Artificial intelligence systems are emerging into clinical practice but due to the way in which these systems are trained on historical data their performance is highly sensitive to variations in the imaging data used as input. Quality assurance and monitoring frameworks that can monitor and verify the performance of these artificial intelligence systems are an unmet need in the medical community including radiation oncology. The goal of this project is to develop and evaluate quality assurance frameworks for several different artificial intelligence use cases in radiation oncology.

PI_NAMEs: HUGO, GEOFFREY D (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;artificial intelligence model;automated segmentation;Biological Models;Clinic;Clinical;Clinical Data;Clinical effectiveness;clinical practice;Clinical Research;Communities;Data;Data Compression;Data Set;data streams;Databases;design;Detection;detector;Development;effectiveness evaluation;Ensure;Environment;Equipment;Error Sources;Expert Systems;Generations;Goals;Half-Life;human data;Image;image reconstruction;image registration;improved;Information Systems;Institution;Label;Link;Magnetic Resonance Imaging;Medical;Methods;Modeling;Monitor;novel strategies;Outcome;Output;patient population;Performance;predictive modeling;predictive tools;prospective;Protocols documentation;quality assurance;Radiation Oncology;Radiation therapy;Safety;Seminal;Series;Shapes;Source;Supervision;System;Testing;Time;tool;Training;training data;treatment planning;Validation;Variant;Work

PROJECT_TITLE: Quality assurance for safe use of AI systems in radiotherapy

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: PROJECT NARRATIVE Mitral valve disease is often under-recognized and not well characterized in echocardiography, the most common form of cardiac imaging. Artificial intelligence has the potential to identify subtle phenotypes, often not recognized by human clinicians, and distinguish between stable asymptomatic incidental findings and high-risk features that can lead to sudden cardiac death and other adverse outcomes. We will leverage deep learning applied to cardiovascular imaging to capture key features of mitral valve disease that could represent intervenable targets for mitigating cardiovascular risk.

PI_NAMEs: OUYANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acceleration;Adult;Adverse event;adverse outcome;Affect;Age;Aging;Anemia;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;artificial intelligence model;automated assessment;Biological Markers;biological sex;biomedical imaging;burden of illness;Cardiac;cardiovascular imaging;cardiovascular risk factor;Cardiovascular system;Characteristics;Chronic;Chronic Kidney Failure;Chronology;Clinical;clinical care;cohort;Cohort Studies;community setting;comorbidity;Compensation;Complementary Health;coronary artery calcium;Data;Data Set;deep learning;deep learning algorithm;Derivation procedure;Diabetes Mellitus;Diagnosis;Dimensions;Disease;disease phenotype;Disease Progression;disorder risk;Early identification;Echocardiography;effective therapy;Electrocardiogram;Epidemiology;experience;explainable artificial intelligence;Eye;Framingham Heart Study;Functional disorder;Future;hands-on learning;health care settings;Health system;Healthcare;Healthcare Systems;Heart;Heart Arrest;Heart failure;heart imaging;Heart Valve Diseases;hemodynamics;high dimensionality;high risk;Human;Hypertension;Image;Incidence;Incidental Findings;Individual;Inflammation;Injury;insight;Knee;knee pain;Left;Left Ventricular Ejection Fraction;Measurement;Measures;Medical center;Medical Imaging;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Morbidity - disease rate;mortality;Motion;Muscle Cells;Myocardial;Myocardial perfusion;neural network;Outcome;outcome prediction;Output;Participant;Pathway interactions;Patients;Pattern;Phenotype;pre-clinical;Ptosis;radiologist;Reporting;response;Risk;San Francisco;serial imaging;Severities;Smoking;Source;spatiotemporal;standard measure;stem;Stress;stressor;Structure;sudden cardiac death;System;Testing;Thick;Time;Training;trait;United States Department of Veterans Affairs;Validation;Ventricular;Ventricular Remodeling;Work;X-Ray Film

PROJECT_TITLE: Deep Learning Based Phenotyping and Outcomes Prediction for Valvular Heart Disease

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Neurosciences;Prevention;Women's Health Research

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative  Cardiovascular disease is the worldwide leading cause of death and is frequently initiated or exacerbated by stress. Further, both chronic stress exposure and heightened physiological reactivity to acute psychological stress predict cardiovascular mortality. Our prior work found that the rodent infralimbic prefrontal cortex divergently regulates male and female stress responses and the goal of this proposal is to determine how sex-specific function of infralimbic projections to the hypothalamus mediate stress-induced cardiovascular susceptibility.

PI_NAMEs: MYERS, BRENT PHILIP (contact)

PROGRAM_OFFICER_NAME: OH, YOUNGSUK

PROJECT_TERMS: Acute;acute stress;Adrenal Glands;Adrenal hormone preparation;Affect;Baroreflex;Biological;biological adaptation to stress;Blood Pressure;Blood Vessels;Cardiac;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cell Nucleus;Cells;Chronic;Chronic stress;Cognitive;combinatorial;Data;Disease;Disproportionately impacts women;Electrophysiology (science);Emotions;Endocrine;Endocrine system;experimental study;Female;Functional disorder;GABA Receptor;gamma-Aminobutyric Acid;Gene Expression;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;health disparity;Heart Hypertrophy;Heart Rate;hemodynamics;Human;Hypothalamic structure;in vivo;Incidence;Investigation;knock-down;Link;male;Measures;Medial;Mediating;mind body interaction;Mood Disorders;mortality;Myocardial dysfunction;nerve supply;neural;neurobiological mechanism;Neurobiology;Neurons;Neuropeptides;Neurosecretory Systems;neurotransmitter release;novel;optogenetics;Outcome;Output;patch clamp;Pathway interactions;Physiological;Physiology;Pituitary Gland;Population;Posterior Hypothalamus;postsynaptic;Predisposition;Prefrontal Cortex;prevent;Process;Psychological Stress;Psychosocial Stress;Rattus;Regulation;response;Risk Factors;Rodent;Severities;sex;Sex Bias;Signal Transduction;Slice;Stress;stress reactivity;Structure;Synapses;System;Telemetry;Testing;Tetanus Toxin;Translating;Vascular Diseases;vascular endothelial dysfunction;Viral;Visceral;Work

PROJECT_TITLE: Prefrontal-hypothalamic circuitry mediates chronic stress-induced cardiovascular susceptibility

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Racial disparities in blood pressure (BP) control persist even after accounting for individual risk factors, and access to healthcare and insurance. Although currently available therapies can achieve high BP control rates, many patients experience uncontrolled BP, and racial disparity in BP control persist likely due to less aggressive treatment and poor patient follow-up. This study aims to explore the extent and determinants of racial/ethnic disparity in hypertension treatment according to recommended guidelines and its impact on patient BP control, with the goal of developing future targeted interventions to improve BP control.

PI_NAMEs: TEDLA, YACOB G (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accounting;Address;Adherence;Advocate;Age;aggressive therapy;Anti-Hypertensive Agents;Asian population;Awareness;Behavior;Black Populations;Blood Pressure;blood pressure control;Body mass index;Cardiovascular system;Caring;Cessation of life;Chronic Disease;Clinic;Clinical;Clinical Practice Guideline;Clinical Research;Clinical Trials;comorbidity;cost;Data;Databases;Demographic Factors;deprivation;Disparity;dosage;Drug Side Effects;Economics;Elderly;Equity;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;Event;evidence base;experience;Failure;Focus Groups;follow-up;Future;Goals;Guidelines;health care availability;health equity;health equity promotion;Health Insurance;Hispanic Populations;Hypertension;hypertension control;hypertension treatment;hypertensive;hypertensives;Hypotension;improved;indexing;Individual;Inequality;information gathering;insight;Insurance;Intervention;Intervention Studies;Interview;Knowledge;Laboratories;Location;low socioeconomic status;Measurement;medical specialties;medication compliance;minority patient;National Health and Nutrition Examination Survey;Neighborhoods;Obesity;Patients;Perception;Pharmaceutical Preparations;Pharmacotherapy;Physicians;Predictive Factor;Prevalence;Provider;provider adherence;Public Health;Race;racial determinant;racial disparity;racial diversity;racial minority;racial population;randomized trial;Recommendation;Reporting;Research;Risk Factors;Role;rural setting;social factors;Southeastern United States;statistics;Surveys;Technology;Titrations;tool;treatment disparity;treatment guidelines;Treatment Protocols

PROJECT_TITLE: Understanding Racial/Ethnic Disparities in Clinician Concordance with Hypertension Treatment Guidelines and Blood Pressure Control

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: SMITH-KETTLEWELL EYE RESEARCH INSTITUTE

PHR: Public Health Relevance Central field loss due to age-related macular degeneration is highly prevalent, debilitating, and can lead to accidents and injury. The individuals’ decreased visual acuity and inability to correctly make compensatory eye movements and exploratory gaze shifts make performing daily tasks such as navigating a crowded street very difficult and even dangerous. This proposal investigates how loss of central vision affects individuals’ ability to look between objects in depth, stabilize objects on the retina during linear motion (e.g., walking), and coordinate eye and head movements to resolve oculomotor conflicts to appropriately meet gaze-shifting demands.

PI_NAMEs: SHANIDZE, NATELA M. (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;Accidents;Address;Affect;Age;Age related macular degeneration;Automobile Driving;Behavior;Blindness;Central Scotomas;Compensation;Conflict (Psychology);Contrast Sensitivity;Crowding;Cues;Dangerousness;Data;Dependence;Depth Perception;Disease;Elderly;Environment;experimental study;Eye;Eye Movements;falls;fovea centralis;gaze;Geometry;Head;Head Movements;Image;improved;Individual;Injury;interest;kinematics;Life Style;Location;Locomotion;monocular;Motion;Movement;Nature;object motion;oculomotor;oculomotor behavior;older adult;Participant;Pattern;Planet Earth;Play;Positioning Attribute;Poverty;prevent;Primates;Productivity;public health relevance;Reflex action;rehabilitation strategy;response;Retina;Rotation;Saccades;sample fixation;Scotoma;Sensory;Smooth Pursuit;Testing;Training;Translations;vestibular reflex;vestibular system;vestibulo-ocular reflex;Vision;Vision Disparity;Visual;Visual Acuity;visual information;Visual System;Walking

PROJECT_TITLE: Oculomotor Demands for Target Stabilization without Central Vision

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-A (02)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Endometriosis;Genetics;Human Genome;Infertility;Pain Research;Precision Medicine;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: NARRATIVE Endometriosis is a common condition, and there is a poor understanding of the genes and noncoding regulatory elements that drive disease development. This project will combine state-of-the-art single cell epigenomics and multiomics with new analytic methods that leverage germline risk information to identify cell types, regulatory elements and genes involved in disease development and outcomes. These insights are expected to pave the way to the development of personalized risk scores and precision medicine for endometriosis.

PI_NAMEs: LAWRENSON, KATE  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Affect;Age;Alleles;Allelic Imbalance;American;analytical method;Anxiety;Automobile Driving;Biological;biomarker identification;candidate marker;Categories;cell type;Cells;central pain;Characteristics;Chromatin;Chromosome Mapping;Chronic;chronic pain;Clinic;Clinical;Cohort Studies;Collaborations;comorbidity;Complex;Data;Data Set;Detection;Development;Diagnostic;dimension reduction;Disease;disease phenotype;Dysmenorrhea;Endometrial;Endometriomas;endometriosis;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Epithelium;Etiology;European ancestry;Excision;experience;Fatigue;Female infertility;fertility improvement;Financial Hardship;follow-up;gastrointestinal;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;genetic predictors;Genetic Risk;Genetic study;Genetic Transcription;Germ Lines;Goals;Gynecologic;Haplotypes;Hemorrhage;Heritability;Immune;immune cell infiltrate;improved;in vivo;Individual;Infertility;Inflammatory;insight;instrument;internal control;Lesion;Life;Link;Maps;Measurement;Mental Depression;Methods;Modeling;Molecular;multidimensional data;multidisciplinary;multimodality;multiple omics;novel;Operative Surgical Procedures;Outcome;outcome prediction;Pain;pain reduction;Patient-Focused Outcomes;Patients;personalized medicine;polygenic risk score;Population;population based;precision medicine;predictive tools;programs;Proteins;Quantitative Trait Loci;Recurrence;Regulator Genes;Regulatory Element;reproductive;Reproductive Medicine;Research;Risk;risk variant;screening;Severities;single cell technology;Societies;Staging;Symptoms;Syndrome;Testing;Time;Tissues;transcription factor;transcriptomics;Translating;tumor-immune system interactions;Untranslated RNA;Variant;Woman

PROJECT_TITLE: Disentangling the genetic mechanisms of endometriosis severity with single-cell multi-omics

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Hematology;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Monosomy 7 (-7) and deletions (del) of the long arm of chromosome 7 (-7/del(7q)) are the most frequent cytogenetic abnormalities and are associated with poor prognosis and chemoresistance. The proposed experiments aim to elucidate the mechanisms of NUP205 deletion in driving the bone marrow insufficiency phenotype, creating specific vulnerabilities, and influencing drug responses, as well as access the efficacy of elesclomol-based combination therapeutics for the treatment of -7/del(7q) malignancies in vivo and in vitro. Our long-term goal is to leverage a deep mechanistic understanding of haploinsufficient essential gene-mediated synthetic lethality to develop innovative therapeutic approaches to treat predisposition syndromes, preleukemia, and leukemia carrying chromosome and copy number deletions.

PI_NAMEs: ZHANG, HAIJIAO  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Affect;Apoptosis;Automobile Driving;Biological Assay;Biological Process;Bone Marrow;bone marrow failure syndrome;Bone Marrow Transplantation;cancer cell;Candidate Disease Gene;Cell Cycle;Cell Cycle Arrest;Cell Cycle Regulation;Cell Death Induction;cell growth;cell killing;Cell Line;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Chemoresistance;chemotherapy;chromosome 5q loss;Chromosome 7;chromosome 7 loss;Chromosome abnormality;Chromosome Arm;Chromosome Deletion;Chromosomes;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Combined Modality Therapy;Complex;Cytarabine;cytopenia;Cytoplasm;Data;demethylation;Development;differential expression;differentiation in vitro;Diploid Cells;Disadvantaged;DNA Damage;DNA Repair;DNA Repair Pathway;dosage;Dose;Drug resistance;Drug Targeting;Dysmyelopoietic Syndromes;Dysplasia;effective therapy;Endonuclease I;Engraftment;Essential Genes;Exhibits;experimental study;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Goals;Growth;Hematologic Neoplasms;Hematology;Hematopoiesis;Hematopoietic Neoplasms;Hematopoietic stem cells;High Prevalence;In Vitro;in vivo;Individual;Ineffective Hematopoiesis;Inherited bone marrow failure;inhibitor;innovation;Innovative Therapy;knock-down;Knock-out;leukemia;Leukemic Cell;Maintenance;Malignant Neoplasms;Mediating;member;Modeling;Molecular;Molecular Profiling;Monosomy 7;Mutation;Myeloproliferative disease;Normal Cell;novel therapeutics;Nuclear;Nuclear Export;Nuclear Pore Complex;overexpression;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Play;Predisposition;Preleukemia;Prognosis;prognostic;Proliferating;Proteins;Proteomics;prototype;Recurrence;research clinical testing;Resistance;response;Ribosomal Proteins;Ribosomes;RNA;Role;Sampling;screening;Shapes;Small Interfering RNA;Solid;Stains;Statistical Data Interpretation;stem cell function;Syndrome;targeted treatment;Therapeutic;therapeutic target;TP53 gene;trafficking;transcriptome sequencing;Translational Research;Validation;Work;Xenograft Model

PROJECT_TITLE: Characterization of NUP205 as a haploinsufficient essential gene for the treatment of  hematopoietic malignancies

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-9 (J1)]


ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Narrative We aim to generate novel bispecific antibody-drug conjugates (bisADCs) against pairs of emerging prostate cancer cell surface antigens expressed by adenocarcinoma and small cell neuroendocrine cancer. BisADCs have unique advantages compared with a mix of monoclonal ADCs, as they trigger synergistic effects through antigen tethering that improve drug delivery and anti-tumor efficacy. By benchmarking against ADCs currently in clinical trials, we will identify lead bisADCs with superior therapeutic index against the two subtypes of prostate cancer, which will be translated to clinical testing in the near future.

PI_NAMEs: LIU, BIN  (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Address;Adenocarcinoma;androgen independent prostate cancer;Animal Model;Animals;antibody conjugate;Antibody-drug conjugates;Antigen Targeting;Antigens;Architecture;Benchmarking;Binding;Binding Sites;Bispecific Antibodies;Cancer Patient;cancer therapy;CD276 gene;CD46 Antigen;Cell surface;Characteristics;Clinic;Clinical;Clinical Trials;Credentialing;Data;design;Development;dimer;Drug Combinations;Drug Delivery Systems;Drug Kinetics;early phase clinical trial;early phase trial;Effectiveness;Epitopes;Exatecan;Future;Heterogeneity;human monoclonal antibodies;improved;In Vitro;in vivo;innovation;interest;Lead;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;Molecular Conformation;Monoclonal Antibodies;nanobodies;Nature;neoplastic cell;neuroendocrine cancer;Neuroendocrine Cell;Neuroendocrine Prostate Cancer;Neuroendocrine Tumors;Neurosecretory Systems;next generation;novel;novel strategies;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Penetration;Pharmaceutical Preparations;Phase;phase I trial;Positioning Attribute;prostate cancer cell;prostate cancer model;Prostate Cancer therapy;Research;research clinical testing;Safety;Sampling;Signal Transduction;small cell lung carcinoma;Solid Neoplasm;success;Surface Antigens;targeted treatment;Testing;Therapeutic;Therapeutic Index;Therapeutic Monoclonal Antibodies;Therapeutic Studies;therapy outcome;Tissues;Toxic effect;Translating;Translations;Treatment Efficacy;Treatment outcome;tumor;Tumor Antigens;uptake;Validation

PROJECT_TITLE: Develop novel bispecific antibody-drug conjugates against metastatic lethal prostate cancer across subtype

STUDY_SECTION: TIO

STUDY_SECTION_NAME: Translational Immuno-oncology Study Section[TIO]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Cancer;Clinical Research;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE We discovered that HMGB1 induces autophagy –a pro-survival mechanism in malignant mesothelioma (MM) that leads to chemo-resistant, and we found that antidepressant drugs (ADs) inhibit autophagy and sensitize MM cells to chemodrugs-induced apoptosis. Moreover, mitochondria protein, Mcl-1, blocks MM cell death when treated with chemotherapy. Here, we propose to study whether ADs may improve chemotherapy and whether that effect is further enhanced in combination with Mcl-1 inhibition.

PI_NAMEs: CARBONE, MICHELE ;RIPLEY, ROBERT TAYLOR;YANG, HAINING  (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acceleration;Acetylation;Address;Alleles;anti-depressive agents;antidepressant effect;Apoptosis;Apoptotic;Asbestos;Autophagocytosis;BAP1 gene;Biological;biomedical referral center;Biopsy;BRCA1 Mutation;carcinogenesis;carcinogenicity;Cell Death;Cell Death Induction;Cell Line;Cell Nucleus;Cell Survival;cell type;Cells;Chemoresistance;chemotherapy;Cisplatin;Clinic;clinically relevant;Constitution;Cutaneous Melanoma;Cytoplasm;Data;Deacetylation;Development;Drug Sensitization;Endoplasmic Reticulum;erionite;Exposure to;extracellular;Fiber;Genes;Growth;HDAC1 gene;HMGB1 gene;Human;Immunotherapy;Impairment;improved;In Vitro;Induction of Apoptosis;Inflammation;inhibition of autophagy;inhibitor;Intervention;intraperitoneal;Link;Malignant - descriptor;Malignant mesothelioma;Malignant Neoplasms;MCL1 gene;Mediating;Mesothelial Cell;Mesothelioma;Mitochondria;Mitochondrial Proteins;Modeling;mouse model;Mutation;Nature;neoplastic cell;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Pathway interactions;patient derived xenograft model;Patients;Pemetrexed;pericardial sac;Peritoneum;Pharmaceutical Preparations;Pharmacotherapy;Pleura;Process;Prognosis;Proteins;Reagent;Renal Cell Carcinoma;Research;Resistance;Resources;response;Risk Factors;Serious Adverse Event;side effect;Testing;therapeutically effective;Translating;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Uveal Melanoma;Xenograft procedure

PROJECT_TITLE: Novel strategies to improve mesothelioma therapy

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Lipids are abundant molecules in the brain and, as a result, are thought to be involved in both the aging process and common age-related neurodegenerative diseases. We recently discovered a new class of anti-inflammatory lipids, called SGDGs, that are greatly reduced in the brain during aging. In this proposal, we aim to understand why SGDG levels decrease with age and whether these lipids contribute to aging and a higher risk of disease.

PI_NAMEs: ELLISMAN, MARK H;SAGHATELIAN, ALAN  (contact);SIEGEL, DIONICIO R

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Age;age difference;age related;age related changes;age related neurodegeneration;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease model;analog;Anti-Inflammatory Agents;Antibodies;Apolipoprotein E;apolipoprotein E-4;Biochemical;Biology;Brain;candidate identification;Carrier Proteins;Cell Line;Cells;Cellular biology;Central Nervous System;Chemicals;Chemistry;Clinical;Complex;Coupling;Custom;dark matter;Data;Degradation Pathway;design;Development;diacylgalactosylglycerol;Diglycerides;Disease;disorder risk;Dryness;Electron Microscopy;Encephalitis;Enzymes;experimental study;frontier;functional group;Genetic;Genomics;Glucocorticoids;Goals;Haptens;Health;high risk;Human;Human Biology;imaging modality;Immune Sera;Immunofluorescence Immunologic;immunogenic;Impaired cognition;improved;in vivo;Inflammation;innovation;Isotope Labeling;Libraries;Ligands;Lipase;lipid metabolism;lipidome;lipidomics;Lipids;Location;Macaca;Measures;Mediating;Metabolic Pathway;Metabolism;Modeling;mouse model;Mus;Myelin;Nerve Degeneration;Neurodegenerative Disorders;novel;Oligodendroglia;Outcome;Pathway interactions;Pharmacology;Phenotype;Positioning Attribute;prevent;Primates;Production;Proteins;Proteomics;Reagent;Regulation;Reporting;Research;Risk;Role;Signal Transduction;Stable Isotope Labeling;Steroids;Structural Chemistry;Structure;Sulfoglycosphingolipids;Techniques;Testing;TLR4 gene;tool;Validation;Weight;Work

PROJECT_TITLE: Function and metabolism of aging lipids in the brain

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Digestive Diseases;Heart Disease;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: Woodland Hills

ORG_NAME: TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION

PHR: PROJECT NARRATIVE Despite the tremendous advancement in organ-on-a-chip technologies, antibody-mediated rejection (ABMR) models on-a-chip have not been developed. Therefore, the overarching goal of this proposal is to engineer a synergistically integrated multi-organ-on-chip platform comprised of biomimetic vascularized human-tissue chips that will recapitulate the pathophysiology of ABMR, which will be coupled with a fully automated, compact, cost- effective, electrochemical biosensor monitoring allograft function and injury. Our goal is to offer a novel platform that can significantly impact transplant immunology research while accelerating the understanding of ABMR, increasing the translation of novel ABMR treatment protocols and regimens to the clinic, and improving organ allocation schemes for highly sensitized patients.

PI_NAMEs: JUCAUD, VADIM  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acceleration;Allogenic;allograft rejection;Allograft Tolerance;Allografting;Animal Model;Antibodies;Antibody Specificity;antibody-mediated rejection;Arterial Fatty Streak;Binding;Biological Markers;Biomimetics;Biosensor;Blood;Cardiac Myocytes;CCL4 gene;Cell Line;Chronic;Clinic;Clinical;clinical translation;Complement 1q;cost effective;Coupled;cytokine;Data;Development;Diagnosis;disease model;donor-specific antibody;drug development;Drug Screening;end-stage organ failure;Endothelial Cells;Endothelium;Engineering;Epitopes;Failure;Fibroblasts;Functional disorder;Genotype;Goals;Growth Factor;Hearing;Heart;Heart Transplantation;Hepatocyte;HLA-A gene;HLA-DRB1;human induced pluripotent stem cells;human model;human tissue;Hypoxia;Immune system;Immunoglobulin G;Immunoglobulin M;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;Inflammation;Injury;Kidney Transplantation;Kinetics;Kupffer Cells;Label;Liver;liver transplantation;Lung;Lung Transplantation;manufacture;Measurement;Mediating;Microcirculatory Bed;Microfabrication;Microfluidic Microchips;Microfluidics;Modeling;Modernization;Monitor;Natural regeneration;novel;Organ;organ allocation;organ on a chip;Organ Transplantation;Organoids;Pathogenicity;Pathologic;Patients;Perfusion;personalized medicine;Physiological;prevent;Protocols documentation;Regimen;Research;response;Risk;Role;Scheme;sensor;Site;Specificity;Swelling;System;Systems Integration;Techniques;Technology;Thrombus;Tissue Microarray;Tissues;Translations;Transplant Recipients;Transplantation;Transplantation Immunology;Treatment Protocols;Validation;vascular bed;Vascularization

PROJECT_TITLE: Vascularized liver-heart on-a-chip modeling antibody-mediated rejection and tolerance of allografts

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: IRVINE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Skeletal muscle is central to everything we do and must repair to meet the vital demands of human life. Human pluripotent stem cells are the only in vitro system that can create unlimited numbers of muscle cells in a dish. How hPSCs commit to all stages of skeletal muscle growth and how to support these muscle cells once they are created is pivotal to improve our understanding of skeletal muscle repair, development, and to design better cell therapies. Skeletal muscle stem cells are supported by their niche, but the molecular cues regulating the niche of hPSC muscle cells has only begun to be explored. This proposal seeks to regulate the hPSC muscle niche to better support the number and function of muscle cells created by hPSCs.

PI_NAMEs: HICKS, MICHAEL RYAN (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 3-Dimensional;Ablation;Actins;Activities of Daily Living;Adult;adult stem cell;Apoptosis;Architecture;Automobile Driving;Basal lamina;Body System;Caspase;Cell Count;Cell Fate Control;Cell Physiology;Cell Therapy;Cell Transplantation;Cells;Characteristics;Chronic;cofactor;combat;Cues;design;Development;directed differentiation;Disease;DNA Sequence Alteration;Embryo;endogenous stem cells;Engineering;Engraftment;exhaustion;experimental study;Extracellular Matrix;fetal;Future;gain of function;Generations;Genes;Genetic;Goals;Growth;HIF1A gene;Human;human interactome;human pluripotent stem cell;human tissue;Hypoxia;improved;In Vitro;in vitro Model;in vivo;Injury;Lead;Life;Ligands;Maintenance;Measures;Molecular;mouse model;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;muscle progenitor cell;muscle regeneration;muscle repair;Muscle satellite cell;Mutate;myogenesis;Myopathy;Natural regeneration;Neural Crest;Outcome;overexpression;Oxygen;PAX7 gene;Phenotype;pluripotency;pluripotent stem cell differentiation;Population;Process;progenitor;receptor;regenerative;Regenerative capacity;regenerative cell;regenerative therapy;Regulation;repaired;Sclerotome;self-renewal;Series;skeletal maturation;Skeletal Muscle;skeletal muscle growth;stem;Stem Cell Development;stem cell homeostasis;stem cell niche;stem cell proliferation;Stem cell transplant;stem cells;Supporting Cell;System;Testing;Therapeutic;Time;Tracer;transcription factor;transcriptome sequencing;Transplantation;transplantation therapy;Work

PROJECT_TITLE: Modulating the Stem Cell Niche Set Point to Improve Skeletal Muscle Regeneration

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Kidney Disease;Patient Safety;Prevention

PHR: PRINCIPAL INVESTIGATOR (LAST, FIRST, MIDDLE): Legrand, Matthieu Project Narrative Hypotension during surgery and anesthesia is a major contributor to postoperative acute kidney injury (PO-AKI), which is associated with higher risk of cardiovascular events, chronic kidney disease, higher costs, and mortality. Vasopressors are the key pharmacologic intervention to correct general anesthesia-induced vasodilation but the best vasopressor to use is unknown. We propose to perform a multicenter cluster randomized, multiple-crossover trial of phenylephrine versus norepinephrine in adult patients undergoing major non-cardiac surgery to answer the question of the best vasopressor to prevent PO-AKI. VEGA-2 M.Legrand June 2023 1

PI_NAMEs: KHETERPAL, SACHIN ;LEGRAND, MATTHIEU  (contact)

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Abdomen;Acute Renal Failure with Renal Papillary Necrosis;Adrenergic Agents;Adult;Agonist;Anesthesia procedures;Bayesian Analysis;Cardiac;Cardiac Output;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Clinical;clinical care;Cluster randomized trial;cohort;Complication;Consensus;cost;Coupling;Critical Illness;Cross-Over Trials;Data;design;Detection;Enrollment;Event;feasibility trial;functional status;Future;General Anesthesia;Glomerular Filtration Rate;Guidelines;Health;Health Care Costs;Health system;Heart failure;Hemorrhage;Heterogeneity;high risk;hospital readmission;Hospitalization;human old age (65+);hypoperfusion;Hypotension;improved;Incidence;Individual;Inflammation;Infusion procedures;Intervention;Intravenous;Kidney;Kidney Diseases;Learning;Level of Evidence;Medicine;Mission;Modernization;mortality;mortality risk;National Institute of Diabetes and Digestive and Kidney Diseases;Norepinephrine;open label;Operative Surgical Procedures;Organ;Outcome;Patient-Focused Outcomes;Patients;Perfusion;Perioperative;pharmacologic;Phenylephrine;pilot trial;Population;Postoperative Period;prevent;Prevention;Principal Investigator;Probability;Property;Public Health;Randomized;randomized trial;Recommendation;Recording of previous events;Renal Blood Flow;Risk;Sample Size;secondary outcome;Shock;Subgroup;systemic inflammatory response;treatment effect;United States;Vascular Permeabilities;Vasoconstrictor Agents;Vasodilation

PROJECT_TITLE: The choice of vasopressor to prevent postoperative acute kidney injury after major non-cardiac surgery: a multicenter pragmatic cluster cross-over randomized trial (the VEGA-2 trial)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Disorders such as major depression, schizophrenia, and autism spectrum disorders are marked by debilitating deficits in social interactions, but our lack of understanding of the basis of social interactions presents a major roadblock to developing neural circuit-based therapies to treat them. Here, we propose to study the single-neuron and circuit basis of cooperation and inter- brain synchronization using rhesus macaques playing cooperative social games. We will investigate how recent social interactions shape neural representations and the causal basis of cooperation.

PI_NAMEs: HAROUSH, KEREN  (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adaptive Behaviors;Address;Affect;affective neuroscience;Animals;Anterior;Architecture;Area;autism spectrum disorder;Behavior;Behavioral;Brain;cingulate cortex;Cognition;Common Good;Complex;Cooperative Behavior;Cortical Synchronization;Data;deep learning model;Dependence;design;Disease;Dorsal;experience;falls;Future;Goals;Human;Impairment;Individual;individuals with autism spectrum disorder;innovation;Investigation;Joints;Lateral;Link;Macaca mulatta;Major Depressive Disorder;Maps;Mathematics;Medial;Mental disorders;Monkeys;National Institute of Mental Health;Nervous System Disorder;neural;neural circuit;neuronal circuitry;Neurons;neurophysiology;nonhuman primate;Personal Satisfaction;Play;Population;Prefrontal Cortex;Primates;Prisoner's Dilemma;Process;programs;Publishing;response;Rewards;Role;Schizophrenia;Shapes;social;social attachment;Social Behavior;Social Change;social cognition;social deficits;Social Environment;Social Functioning;Social Interaction;social neuroscience;Societies;Sum;Thalamencephalon;Time;Update

PROJECT_TITLE: Organizing Principles of the Neural Circuits for Social Interaction

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: Project Narrative  Impairments in new learning and memory are common in Multiple Sclerosis (MS) and negatively impact several important aspects of everyday life (e.g., social and occupational functioning), but treatment options are limited due to the lack of cognitive rehabilitation (CR) protocols supported by Class I research evidence. To address this critical need, the presently proposed randomized clinical trial (RCT) examines the efficacy of an 8-session CR protocol encompassing training in the application of three strategies (self-generation, spaced learning, and retrieval practice) with the greatest empirical evidence to treat impaired learning and memory in persons with MS: Strategy-Based Training to Enhance Memory (STEM). Results are expected to substantially improve our ability to treat learning and memory deficits in persons with MS, which would lead to improved everyday functioning and overall quality of life for persons with MS, as well as reduced caregiver burden.

PI_NAMEs: CHIARAVALLOTI, NANCY D. (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Address;Aftercare;Brain;Caregiver Burden;Cognition;cognitive performance;cognitive rehabilitation;Cognitive Science;daily functioning;Data;design;Development;disability;Disabled Persons;Double-Blind Method;Educational process of instructing;efficacious treatment;efficacy evaluation;efficacy testing;Evaluation;evidence base;follow-up;Generations;Impairment;improved;Individual;innovation;interest;Intervention;Learning;Life;Literature;Manuals;Measures;Medical center;Memory;Memory impairment;Methodology;Multiple Sclerosis;multiple sclerosis patient;National Institute of Child Health and Human Development;neural correlate;neuroimaging;neuromechanism;Neuropsychology;novel;Occupational;optimism;Outcome;Outcome Measure;Participant;Patients;Performance;Population;Population Intervention;Protocols documentation;Publications;Quality of life;Questionnaires;randomized placebo-controlled clinical trial;randomized, clinical trials;Recommendation;reduce symptoms;rehabilitation research;Rehabilitation therapy;remediation;Research;Research Design;Retrieval;self testing;Shivering;social;Social Functioning;Societies;Standardization;standardize measure;Structure;Techniques;theories;Time;Training;treatment effect;Treatment Protocols;United States National Institutes of Health;Work

PROJECT_TITLE: Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Heart Disease;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: NARRATIVE The incidence of dementia is dramatically increasing, and there is an urgent need to identify risk factors and prevention strategies for cognitive impairment and dementia, including Alzheimer’s disease. There is growing recognition that cardiovascular integrity is associated with abnormal brain changes and cognitive impairment. The proposed project will generate evidence to support the development of novel strategies for delaying dementia onset and progression.

PI_NAMEs: JEFFERSON, ANGELA L. (contact)

PROGRAM_OFFICER_NAME: SILVERBERG, NINA B

PROJECT_TERMS: Acceleration;Accounting;Adult;Affect;Age;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer’s disease biomarker;Aorta;Apolipoprotein E;Atrophic;Biological Markers;Blood brain barrier dysfunction;Blood flow;Blood Vessels;Brain;brain abnormalities;brain health;Cardiac;Cardiovascular Physiology;Cardiovascular system;cerebral atrophy;cerebral hemodynamics;Cerebrospinal Fluid;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Cerebrum;Clinical;Cognition;Cognitive;cognitive change;cohort;Data;Dementia;design;Development;Disease;Early Diagnosis;Enrollment;executive function;extracellular;Extracellular Matrix;follow-up;Functional disorder;Funding;genetic risk factor;Grant;hemodynamics;Hippocampus;Human;Impaired cognition;in vivo;Incidence;Individual;Inflammation;Inflammatory;Influentials;Injury;innovation;insight;K-Series Research Career Programs;Link;Low Cardiac Output;Mediating;Memory;Memory Loss;Modeling;Modification;molecular marker;National Research Service Awards;Nerve Degeneration;neuroimaging;neuroimaging marker;neuropathology;novel;novel strategies;older adult;Outcome;outreach;Paper;Participant;Pathologic Processes;Pathology;Pathway interactions;Physiologic pulse;Population;Predisposing Factor;prevent;Prevention strategy;Procedures;Process;prospective;Public Health;Publishing;recruit;Research;Risk Factors;Role;Spinal Puncture;structural imaging;Structure;success;Symptoms;Synapses;tau-1;Techniques;Testing;Time;Training;Vascular blood supply;vascular factor;white matter change;white matter damage

PROJECT_TITLE: Vanderbilt Memory & Aging Project

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: Project Narrative: The South Texas MSTP trains the next generation of well-rounded physician scientists in an interdisciplinary training environment with translational science and health disparities components. A special focus is on the social determinants of health and needs of a growing Hispanic and impoverished patient population in the US, populations with high prevalence in South Texas.

PI_NAMEs: CAVAZOS, JOSE E (contact);VADLAMUDI, RATNA K;ZANG, MENGWEI

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: South Texas Medical Scientist Training Program (STX-MSTP)

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE The cell surface proteome (surfaceome) is the primary hub cells use to interact with the outside. Here we will develop small-scale surfaceome proteomics techniques allowing access to rare cell types, a new high- resolution antibody-based proximity labeling method to characterize cell surface signaling interactomes, and validate using recombinat antibody probes to critical cell surface targets.

PI_NAMEs: WELLS, JAMES A (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Advanced Development;Antibodies;Antineoplastic Agents;Bacteriophages;Biological Markers;Cell membrane;Cell surface;Cell Surface Proteins;cell type;Cells;Complex;Cytokine Receptors;Development;Disease;Drug Targeting;Energy Transfer;Environment;Epidermal Growth Factor Receptor;Family;Generations;Goals;Grant;Health;Immunology;improved;induced pluripotent stem cell;Label;Malignant Neoplasms;Maps;Mediating;Membrane;Membrane Proteins;Methods;Minority;Modeling;Nerve Degeneration;Neurology;Oncogenes;Patients;Phenotype;Population;Process;protein complex;Protein Secretion;Proteome;Proteomics;receptor;Recombinants;Regulation;Resolution;Sampling;Science;Signal Transduction;T-Lymphocyte;Techniques;Technology;Vision;Yeasts

PROJECT_TITLE: Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolution

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Microbiome;Precision Medicine

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Interindividual variation in the effectiveness of cancer chemotherapy cannot be fully explained or predicted, resulting in health risks to patients and inefficient utilization of limited healthcare resources. While variations in the gut microbiome of patients have been shown to influence treatment outcomes, the mechanisms by which these microbes change chemotherapeutic drug disposition remain poorly understood. Based on our strong in vivo and in vitro data showing that a prevalent gut microbe inhibits a key drug efflux transporter, this proposal will expand our mechanistic understanding of host-microbiome interactions in drug disposition and provide the first step towards using microbial genes and/or metabolites as predictive markers for cancer chemotherapy.

PI_NAMEs: KYAW, THAN SOE (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: ABCB1 gene;Actinobacteria class;Adjuvant;Affect;Affinity;Antineoplastic Agents;ATP-Binding Cassette Transporters;Binding;Biochemical;Biological Availability;Body Weight decreased;California;cancer cell;Cancer Model;cancer therapy;Candidate Disease Gene;career;Cell Death;Cell Line;Cells;Cellular Assay;Chemoresistance;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;colon cancer cell line;Colorectal Cancer;comorbidity;comparative;comparative genomics;CRISPR/Cas technology;cytotoxic;Cytotoxic agent;Data;demographics;diagnostic biomarker;Dose Limiting;Doxorubicin;drug disposition;drug efficacy;Drug Efflux;Drug Kinetics;drug response prediction;Drug toxicity;Effectiveness;Environment;Enzymes;Escherichia coli;Etiology;experimental study;Fluorescence;Fluorescent Probes;Foundations;Fractionation;Genes;Genetic Polymorphism;Genetic Transcription;Germ-Free;Gnotobiotic;Goals;Guide RNA;gut microbes;gut microbiome;Health;Healthcare;Heterogeneity;Histology;host microbiome;Human;imaging system;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;in vivo fluorescence imaging;Incubated;inhibitor;insight;inter-individual variation;Kinetics;Knock-out;Measures;Mediating;Medical;medical schools;member;Metabolism;metabolomics;Methods;Microbe;microbial;microbial community;microbiome;microbiome research;microbiota;Morbidity - disease rate;mortality;Mus;Nature;Oral;Patients;Pharmaceutical Preparations;Physicians;Play;predictive marker;Prognostic Marker;Proliferating;Reader;Rectal Cancer;Rectal Neoplasms;Rectum;Research;Research Project Grants;Resistance;Resources;Risk;Role;San Francisco;Scientist;Serum;Shapes;small molecule;Specificity;Staging;Testing;Therapeutic;therapy outcome;Toxic effect;Toxicity due to chemotherapy;Training;Training Programs;Transcriptional Activation;Transplantation;Treatment outcome;treatment response;tumor;Universities;Variant;Vesicle;Weights and Measures;Xenograft Model

PROJECT_TITLE: Impact of the microbiome on chemotherapeutic outcomes


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative New therapeutic strategies are badly needed in Early T-cell precursor Acute Lymphoblastic Leukemia (ETP- ALL), yet current biological understanding of this subtype of pediatric leukemia is limited. The completion of COG’s AALL00344 clinical trial, which enrolled 325 ETP-ALL patients, represents an exciting opportunity to improve our understanding of the biological reasons for treatment failure. Using single cell multi-omics coupled with patient-specific and large-scale computational validation studies, we will define molecular features of ETP- ALL that explain treatment resistance, improve understanding of carcinogenesis and its relation to normal T-cell development, and define novel targetable genes and pathways for patients with ETP-ALL.

PI_NAMEs: XU, JASON  (contact)

PROJECT_TERMS: Accounting;Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Automobile Driving;B-Lymphocytes;Biologic Characteristic;Biological;Biological Assay;Biological Models;Bone Marrow;cancer diagnosis;carcinogenesis;CD32 Antigens;Cell Line;Cell surface;cell type;Cells;Cellular Assay;Characteristics;chemotherapy;Childhood Leukemia;Chromatin;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Common Acute Lymphoblastic Leukemia;Computer Analysis;conventional therapy;Coupled;Cytoplasm;Data;Data Analyses;Development;Diagnosis;Disease remission;Early identification;Early treatment;Enrollment;Epigenetic Process;Equilibrium;Flow Cytometry;Gene Expression;Gene Expression Profile;Genes;Genetic;Goals;Grant;Hematopoietic stem cells;high risk;Immunophenotyping;improved;In complete remission;Inferior;Knowledge;Lead;Lymphoid;Lymphoid Cell;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Measurement;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;multiple omics;Mutation;Myelogenous;myeloid cell development;Myeloid Cells;Myeloid Progenitor Cells;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Pharmacological Treatment;Phenotype;Population;Postdoctoral Fellow;Process;progenitor;prognostic;prognostic signature;prospective;Publishing;Regimen;Relapse;Residual Neoplasm;response;risk stratification;Sampling;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;Small Interfering RNA;Stains;stem;stem cells;stemness;synergism;T-Cell Development;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Thymus Gland;tool;transcriptome sequencing;transcriptomics;Transposase;Treatment Failure;treatment response;United States National Institutes of Health;validation studies;Work

PROJECT_TITLE: Analysis of Developmental Arrest and Treatment Resistance in High-risk T-ALL


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Neurosciences;Prevention

ORG_CITY: CHAPEL HILL

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Program Narrative Approximately 25% of persons in the United States have an audiometric signs of hearing loss consistent with noise damage, and this hearing loss impacts their ability to understand speech and discern different sounds. Although the primary cause of hearing loss is damage to the hair cells in the cochlea, the central nervous system also undergoes changes in how the remaining auditory signal is processed and perceived. In this proposal, we examine changes to the brain mechanisms in the first part of the brain that processes sound, the cochlear nucleus, in order to help develop optimal strategies to correct for hearing loss, and to understand how sound (including speech) discrimination and perception are affected by hearing loss.

PI_NAMEs: MANIS, PAUL B (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acoustics;Adolescent;Adult;Affect;Age;Aging;American;Animals;Audiology;Auditory;auditory processing;Auditory system;Axon;Bilateral;Brain;Caliber;cancer therapy;Cell Nucleus;cell type;Cells;Central Nervous System;Cochlea;Cochlear nucleus;Code;Cognition;Communication;Complex;Computer Models;Dendrites;Detection;Development;Discrimination;dorsal cochlear nucleus;Environment;Environmental Risk Factor;Etiology;Exposure to;Fiber;Frequencies;Functional disorder;ganglion cell;Genetic;Goals;Hair Cells;hearing impairment;Hearing problem;hippocampal pyramidal neuron;Human;Hyperacusis;in vivo;Individual;Infection;information processing;insight;Interneurons;Ion Channel;Ions;juvenile animal;Knowledge;Literature;Loudness;Maps;mature animal;Measures;Modeling;Molecular Profiling;Mus;Nerve Fibers;nerve supply;neural circuit;Neurons;Noise;Noise-Induced Hearing Loss;novel;Occupational;Output;Pathway interactions;Pattern;Perception;Peripheral;Persons;Pharmacotherapy;Population;Poverty;Process;programs;Pyramidal Cells;Rattus;receptor;Recreation;Residual state;response;Rodent;Sensory;sensory discrimination;sensory input;sensory integration;Sensory Thresholds;Signal Transduction;Slice;Social isolation;sound;Speech;spiral ganglion;stimulus processing;Synapses;synaptic function;Synaptic Transmission;Testing;Tinnitus;Training;United States;virtual;Work

PROJECT_TITLE: Cellular Mechanisms of Auditory Information Processing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative/Relevance: Atherosclerosis is a progressive chronic inflammatory disease that remains the leading cause of death in the USA and worldwide in spite of widespread use of statins, other lipid lowering strategies, and life-style modifications. Remarkably, despite decades of research, little is known about late stage lesion development and mechanisms that result in the rupture or erosion of the protective fibrous cap overlying advanced atherosclerotic lesions leading to catastrophic thrombotic events including a heart attack (i.e. myocardial infarction) or stroke. The goal of studies in this proposal is to develop novel approaches for reducing the late stage clinical complications of atherosclerosis through dietary and/or pharmacological approaches that induce metabolic reprogramming of the key cell types that we have recently shown form the protective fibrous cap, enabling them to form a thicker and mechanically more robust fibrous cap (i.e. analogous to a stronger patch on a tire), and thereby reducing the probability of lesion rupture or erosion leading to a possible heart attack or stroke.

PI_NAMEs: OWENS, GARY K (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Accounting;aerobic glycolysis;antagonist;aortic arch;Apolipoprotein E;Arterial Fatty Streak;Atherosclerosis;atherothrombosis;Carotid Endarterectomy;Cause of Death;Cd68;Cell Lineage;Cell Reprogramming;cell type;Cells;Cessation of life;chronic inflammatory disease;Clinical;Clinical Research;Collagen;conditional knockout;Coronary artery;Coronary heart disease;Data;Databases;Development;Diet;dietary;dietary approach;Endothelial Cells;Endothelium;Energy Metabolism;Energy Metabolism Pathway;Event;Exhibits;Extracellular Matrix;Failure;feeding;Flow Cytometry;Genetic;Glucose;Glutamine;Goals;high risk;Histologic;Human;In Vitro;in vivo;indexing;Individual;Inflammation;inhibitor;insight;Investigation;Investments;knock-down;Knock-out;Lactate Dehydrogenase;Lesion;Lesion by Stage;Life Style Modification;Lipids;Macrophage;Maintenance;Manuscripts;Mechanics;Medicine;Mesenchymal;Metabolic;metabolic profile;Microscopic;Modeling;multiplexed imaging;Mus;Myocardial Infarction;Myofibroblast;Nature;novel;novel strategies;Paper;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Play;prevent;Probability;Property;pyruvate dehydrogenase;Research;response;Role;Rupture;Sampling;sex;single-cell RNA sequencing;small hairpin RNA;Smooth Muscle Myocytes;Stroke;Testing;Thick;thrombotic;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;United States;validation studies;western diet

PROJECT_TITLE: Role of Metabolic Reprogramming in Formation and Maintenance of the Acta2+ Atherosclerotic Lesion Protective Fibrous Cap

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Hematology;Immunotherapy;Liver Disease;Prevention;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Gene therapy holds the promise of a lasting cure for the inherited bleeding disorder hemophilia but is troubled by immune responses. The goal of this project is overcome these immunological hurdles so that treatment by gene therapy is long-term in patients.

PI_NAMEs: DE JONG, YPE PETER;HERZOG, ROLAND W. (contact);TERHORST, CORNELIS P

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adeno-associated viral vector;Adrenal Cortex Hormones;anakinra;Animals;antagonist;Antibodies;Antibody Formation;Antibody Response;Antigens;B-Lymphocytes;Blood Coagulation Disorders;Capsid;CD3 Antigens;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Clinical;Clinical Trials;Coagulation Process;Collaborations;Cross Presentation;Cross-Priming;Culture Techniques;cytokine;Cytokine Signaling;Dendritic Cells;Dose;empowerment;Environment;Experimental Designs;Factor VIII;FDA approved;gene product;gene therapy;Gene Transfer;genetic manipulation;Goals;Hemophilia A;Hepatic;Hepatocyte;Hepatology;Human;IL1R1 gene;IL2RB gene;Immune;Immune response;Immune Targeting;Immune Tolerance;Immunodeficient Mouse;Immunologics;Immunology;immunoregulation;Immunosuppression;Immunosuppressive Agents;In Vitro;in vivo;Inherited;inhibitor;Innate Immune Response;innovation;Interferons;Interleukin-1;Interleukin-1 Receptors;Interleukin-15;interleukin-15 receptor;Link;Liver;Macrolides;Memory;Molecular;mouse model;Mus;Myeloid Cells;Natural Killer Cells;neutralizing antibody;nonhuman primate;novel;Oral;Outcome;Outcome Study;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phase III Clinical Trials;preservation;prevent;Production;Protocols documentation;Publishing;Reagent;receptor;Receptor Signaling;Regimen;Regulatory T-Lymphocyte;Role;Signal Pathway;Signal Transduction;Sirolimus;T cell response;T-Cell Receptor;Testing;Toxic effect;transgene expression;Transgenes;vector;Viral;Viral Genes;Viral Vector;virology

PROJECT_TITLE: Enhancing immune regulation in gene therapy for hemophilia

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Osteoporosis

ORG_CITY: BALTIMORE

ORG_DEPT: ORTHOPEDICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PUBLIC HEALTH RELEVANCE STATEMENT (NARRATIVE) Increasing clinical evidence suggests an association between osteoporosis and Alzheimer's disease (AD), two age-related disorders, but the underlying mechanisms remains poorly understood. Our goal is to define the mechanisms by which bone-derived cues regulate brain aging. With this work we hope to develop novel strategies for early AD treatment.

PI_NAMEs: WAN, MEI  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Ablation;Acceleration;Affect;Age;age acceleration;age related;age-related disease;Aging;aging brain;aging mechanism;Alzheimer's Disease;Alzheimer's disease pathology;animal old age;Attenuated;Blood;Blood - brain barrier anatomy;Blood Circulation;Blood Vessels;bone;Bone Density;Bone Diseases;bone loss;Bone Marrow;Bone Marrow Cells;Bone Marrow Transplantation;Bone Resorption;Brain;brain dysfunction;Brain Pathology;brain pericytes;Cell Aging;Cell secretion;Cell Separation;Cells;Central Nervous System;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Clinical;Cognitive;Cognitive deficits;comorbidity;Cues;cytokine;Data;Dementia;dementia risk;density;Development;Diagnostic;Diffuse;Disease;Disease Progression;Early treatment;Elderly;Endothelial Cells;Endothelium;Functional disorder;Genetic;Goals;Growth Factor;Health;Hippocampus;Homeostasis;Human;human old age (65+);Impairment;In Situ;Incidence;juvenile animal;Knock-in;Knock-in Mouse;Knock-out;Link;migration;Modeling;Mononuclear;Mouse Strains;Mus;Neurodegenerative Disorders;neuropathology;neutralizing antibody;novel strategies;old mice;Organ;Osteoclasts;Osteoporosis;Pathologic;Patients;Pericytes;Permeability;Phenotype;Physiological;platelet-derived growth factor BB;Population;Positioning Attribute;pro-aging;Proliferating;promoter;public health relevance;Rattus;receptor internalization;Reporter;risk prediction;Role;senescence;senescent cell;Senile Plaques;Serum;Signal Transduction;skeletal;Sorting;Source;Testing;Tissues;Transgenic Mice;Transgenic Organisms;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Role of Cellular Senescence in the Bone-Brain Interplay

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed MARC-WSU program will equip high achieving juniors and seniors from underrepresented groups with the skills needed to complete their undergraduate degrees, matriculate into a graduate program, and pursue a career as a leader in biomedical research. Through the MARC-WSU program, a diverse and well-trained pool of scientists and engineers will contribute to creative and innovative health solutions allowing the United States to remain a world leader in biomedical sciences. Moreover, by increasing diversity in the biomedical sciences workforce MARC-WSU will enable the United States to eliminate health disparities across the nation by providing an empathetic workforce that reflects all socioeconomic backgrounds.

PI_NAMEs: GIZERIAN, SAMANTHA ;KOSTYUKOVA, ALLA S.;LANIER, MARY SANCHEZ (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Bachelor's Degree;Biomedical Research;career;CCL7 gene;community building;Critical Thinking;Data Analyses;Development;Doctor of Philosophy;Educational workshop;empowerment;Engineering;Ethics;experience;Experimental Designs;Future;Goals;health disparity;improved;Individual;innovation;Knowledge;knowledge integration;Laboratories;Leadership;matriculation;Measures;Mentors;oral communication;Outcome;Pathway interactions;peer coaching;Personal Satisfaction;programs;Research;resilience;Science;Self Efficacy;skills;Students;success;supportive environment;symposium;System;systemic barrier;tool;underserved community;Universities;Washington;Work;Writing

PROJECT_TITLE: MARC at Washington State University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative (Relevance) Episodic memory plays a key role in children's social and cognitive development, and likely influences life outcomes in adulthood, but young children have poor memories for past events. In this grant, we propose a theory-based and innovative series of studies in which we measure component processes of episodic memory longitudinally, while also collecting measures of structural brain changes and measures of real-world autobiographical memory. Findings from the proposed studies will lead to a better theoretical framework to facilitate healthy development and to ground intervention methods with at-risk populations such as children with temporal lobe epilepsy, Down Syndrome or Type 1 diabetes.

PI_NAMEs: NEWCOMBE, NORA STEFANIE (contact);OLSON, INGRID R

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Adult;Amnesia;Area;Autobiography;Behavior;behavior test;Behavioral;Binding;Biological Models;Brain;Child;Childhood;Cognition;cognitive development;cohort;Complex;Comprehension;critical developmental period;Data;dentate gyrus;Development;Diffusion;Down's Syndrome;elementary school;Elements;Episodic memory;Etiology;Evaluation;Event;experience;Future;Generations;Grant;gray matter;Hippocampus;Image;improved;Individual;infancy;Infant;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;Laboratories;Language;language comprehension;Learning;Life;Link;Location;Longitudinal Studies;Magnetic Resonance Imaging;Maps;mathematical model;Mathematics;Measures;Memory;Methods;Modeling;neocortical;neural;neurodevelopment;Nursery Schools;Outcome;Pathway interactions;Pattern;Perforant Pathway;Performance;Personal Satisfaction;Persons;Play;Populations at Risk;Process;Publishing;Research;Retrieval;Series;Social Development;Structure;System;Temporal Lobe Epilepsy;Testing;theories;Time;Toddler;Trace Elements;virtual;Vocabulary;white matter;white matter change;Work

PROJECT_TITLE: Mapping the Development of Episodic Memory


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Drug resistance in targeted cancer therapy usually occurs in solid tumors. This project aims to identify the biological and structural bases of resistance to aid in the selection and development of a pipeline of drugs to delay the progression of tumors. This project is relevant to the mission of the National Cancer Institute because it will lead to longer survival of patients with cancer and an eventual cure for the disease.

PI_NAMEs: AHNERT, JORDI RODON;MOOERS, BLAINE H. M.;WU, JIE  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Animals;base;Biological;Bypass;Cancer Patient;cancer therapy;cell free DNA;Cells;Clinic;Clinical;clinical development;Complex;Data;Databases;design;Development;Disease;Disease Management;Disease Progression;Drug resistance;drug sensitivity;drug structure;Drug Tolerance;effectiveness evaluation;experience;Foundations;Generations;Genes;Goals;Human;improved;in vivo;in vivo evaluation;inhibitor;insight;Knowledge;Laboratories;Link;Lung Neoplasms;Malignant neoplasm of thyroid;Malignant Neoplasms;Maps;Methods;Mission;Modeling;Molecular Biology;Molecular Conformation;mutant;Mutation;National Cancer Institute;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Outcome;Patients;personalized management;Pharmaceutical Preparations;pharmacologic;Phosphotransferases;Plasma Cells;Pre-Clinical Model;Precision cancer therapy;Protein Tyrosine Kinase;Proteins;PTK2 gene;Recurrent tumor;Residual Neoplasm;Residual state;Resistance;Resistance development;resistance mutation;response;RET gene;Roentgen Rays;Signal Transduction;Solid Neoplasm;Structure;Study models;System;targeted cancer therapy;targeted treatment;Testing;Transfection;Transgenic Mice;translational impact;treatment response;tumor;tumor progression;Tumor Promotion;Tumor Suppression;Tumor-Derived;Tyrosine Kinase Inhibitor;United States Food and Drug Administration;Validation;Variant

PROJECT_TITLE: Blocking tumor progression in therapy-responsive RET aberration-associated cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation

PHR: The long-term goal is to develop effective physical rehabilitation approaches to improve balance and gait to prevent falls in people with Parkinson’s disease and other elderly people at high fall risk. To reach this goal, we will identify objective measures of turning, gait and mobility activity during daily life that best reflect fall risk and to explore the use of home monitoring of mobility as outcome measures for rehabilitation to improve turning quality. We will also test the effectiveness of a Turning Boot Camp rehabilitation intervention to improve quality of turning and mobility in people with Parkinson’s disease. 05-08-17

PI_NAMEs: HORAK, FAY BAHLING (contact);MANCINI, MARTINA

PROJECT_TERMS: active control;Affect;Age;Boxing;Characteristics;Chronic Disease;Clinical;clinical practice;Clinical Trials;community living;Cross-Sectional Studies;Data;design;Disease;Effectiveness;effectiveness testing;Elderly;Ensure;equilibration disorder;Equilibrium;exercise intervention;exercise program;experience;Fall prevention;fall risk;falls;flexibility;foot;Fracture;functional outcomes;Future;Gait;Gait abnormality;Goals;Healthcare;Hip Fractures;Home;Hour;Impairment;improved;improved mobility;innovation;Intervention;Intervention Studies;Life;Measurement;Measures;Mobility disability;mobility rehabilitation;Monitor;Nervous System Disorder;new technology;novel;Outcome;Outcome Measure;Parkinson Disease;Parkinsonian Disorders;Persons;Pharmaceutical Preparations;Physical Rehabilitation;Pilot Projects;programs;prospective;Prospective Studies;Protocols documentation;Randomized;Recording of previous events;recruit;Rehabilitation therapy;Reporting;sensor;Severity of illness;strength training;Tai Ji;Testing;Time;Walking;wearable sensor technology;Weight

PROJECT_TITLE: Mobility in Daily Life and Falls in Parkinson's Disease: Potential for Rehabilitation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: AMES

ORG_DEPT: MISCELLANEOUS

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: Dynamic rearrangements of the actin cytoskeleton are essential to all eukaryotic cells. Defects in actin regula- tion are associated with various diseases, ranging from immunodeficiency and neurodevelopmental disorders to cancer metastasis and pathogen infection. The proposed research will determine the fundamental mecha- nisms of central actin regulators known as the Wiskott-Aldrich Syndrome Protein (WASP) family proteins, which will lay the foundation for understanding how actin remodeling is dysregulated in diseases and can be treated therapeutically.

PI_NAMEs: CHEN, BAOYU  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Address;axon guidance;Binding;Binding Sites;Biochemistry;Biology;Cell membrane;cell motility;Collaborations;Complex;Cryoelectron Microscopy;Cytoskeleton;Defect;Development;Disease;DNA Sequence Alteration;Eukaryotic Cell;experimental study;field study;Fluorescence;Fluorescence Microscopy;Foundations;Guanosine Triphosphate Phosphohydrolases;human disease;Human Pathology;Immune;immune activation;Immunologic Deficiency Syndromes;Individual;Infection;interest;Knowledge;Laboratories;Ligands;Link;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Monomeric GTP-Binding Proteins;Morphogenesis;Mutation;Names;Neoplasm Metastasis;Neurodevelopmental Disorder;Neurons;novel;Oxidation-Reduction;Parasitic infection;particle;pathogen;Patients;Phosphatidylinositols;Play;polymerization;Polymers;Process;Protein Engineering;Protein Family;Proteins;receptor;Regulation;Research;Role;Series;Signal Transduction;single molecule;Syndrome;Therapeutic;trafficking;vasodilator-stimulated phosphoprotein;Vesicle;WAVE protein;Wiskott-Aldrich syndrome protein;Work

PROJECT_TITLE: Signal Integration from Membranes to the Actin Cytoskeleton


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

ORG_STATE: MA

PHR: PROJECT NARRATIVE A three-week intensive lecture- and laboratory-based course will be held at an institution renowned for advanced research courses, with the overall goal of attracting new investigators to research on normal and disordered hearing and balance. Course participants at various stages of training (all post-undergraduate) will work shoulder-to-shoulder with many expert course faculty to learn cutting-edge experimental approaches specific to auditory and vestibular biology as well as the potential for conducting research that improves the lives of patients. The course experience will initiate scientific networks for the course participants and, as a corollary benefit, increase interactions among established investigators from different sub-fields of hearing, balance, and related research.

PI_NAMEs: EATOCK, RUTH ANNE;GROVES, ANDREW K;HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acceleration;Address;Affect;Age;American;Area;Atmosphere;Auditory;Automobile Driving;Biological;Biological Models;Biology;career;career development;Central Nervous System;Chalk;Clinical;Collaborations;Communication;Communities;Complex;design;Development;Developmental Cell Biology;economic impact;Education;education research;Educational Curriculum;Educational process of instructing;Enrollment;Environment;equilibration disorder;Equilibrium;experience;Faculty;Feedback;Fostering;Foundations;Functional disorder;gene therapy;Genetic;Goals;graduate student;Health;Hearing;hearing impairment;Hearing problem;Human;improved;innovation;Institution;Instruction;instructor;interest;Investigation;Knowledge;Laboratories;laboratory curriculum;laboratory experience;Labyrinth;lateral line;Learning;lectures;marine;Mentors;Methods;Modeling;Molecular;neural;neural prosthesis;neurophysiology;next generation;Participant;Pathway interactions;Patients;peer networks;Population;Postdoctoral Fellow;Problem Solving;programs;recruit;Research;Research Personnel;Research Project Grants;Research Training;response;role model;Science;Scientific Inquiry;Scientist;Sensory;Shoulder;Side;Site;socioeconomics;stem cell biology;Structure;Students;System;Talents;Technical Expertise;Techniques;theories;Time;tool;Training;Translating;translational progress;Translations;undergraduate student;Underrepresented Populations;Underrepresented Students;Vestibular dysfunction;vestibular system;Work

PROJECT_TITLE: Advanced Research Training in the Biology of the Inner Ear and Related Systems


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Prevention;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Although the clinical high risk for psychosis (CHR) criteria offer an important public health target and opportunity to prevent psychotic disorders, substantial heterogeneity exists in CHR both at ascertainment and in outcome that limits treatment development. Our 26 international sites will recruit 1040 CHR and follow them with clinical and biomarker assessments over two years, along with 260 healthy controls assessed at baseline. In partnership with the Data Processing, Analysis, and Coordinating Center, we will contribute to analyses to dissect the heterogeneity of CHR and develop tools for outcome definition and patient stratification.

PI_NAMEs: BEARDEN, CARRIE E;KANE, JOHN M;WOODS, SCOTT W (contact)

PROGRAM_OFFICER_NAME: MORRIS, SARAH ELIZABETH

PROJECT_TERMS: Address;Affect;Affective Symptoms;Anxiety;Architecture;Attenuated;attenuated psychosis syndrome;behavior measurement;Behavioral;behavioral health;behavioral outcome;Biological Markers;biomarker driven;Body Fluids;Brain;brain behavior;Brain Mapping;Cellular Phone;Clinical;Clinical Drug Development;clinical heterogeneity;clinical high risk for psychosis;clinical outcome measures;Clinical Trials;clinically actionable;clinically relevant;Cognition;Cognitive deficits;Collaborations;Communities;computerized data processing;Data;Data Aggregation;data archive;data integration;Databases;design;Development;digital phenotyping;Disease;Ecological momentary assessment;effective therapy;Electrophysiology (science);Evaluation;falls;Family;Functional impairment;Future;gamma-Aminobutyric Acid;Genetic;Glutamates;Glutamine;Goals;healthy volunteer;Heterogeneity;high risk;Image;improved;Individual;individual patient;Informatics;insight;interest;International;Intervention;Intervention Studies;Knowledge;Language;Left;Link;Liquid substance;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maps;Measures;Medicine;member;Mental Health;Methods;Monitor;multimodality;National Institute of Mental Health;neural;Neurobiology;novel;Onset of illness;Outcome;Participant;Pathogenicity;patient stratification;Patients;Pattern;personalized medicine;personalized predictions;Phase;Phenotype;predictive marker;prevent;Procedures;Prognostic Marker;programs;prospective;Psychopathology;Psychoses;psychosis risk;Psychotherapy;Psychotic Disorders;psychotic symptoms;Public Health;recruit;Reporting;Research;Risk;Sampling;Schizophrenia;schizophrenia risk;Secure;sensor;Services;severe mental illness;Site;Speech;Standardization;Stratification;Structure;success;Surveys;Symptoms;Syndrome;Testing;Therapeutic;therapy development;Time;tool;Validation;Variant;working group;Youth

PROJECT_TITLE: ProNET: Psychosis-Risk Outcomes Network


NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PHR: PROJECT NARRATIVE For use in low- and middle-income countries, we propose to develop an affordable, automated colorectal cancer detection (GeneXpert® CRC-MD) assay that analyzes our published, hypermethylated DNA panel in plasma to rapidly detect malignancy. In collaboration with our industry partner, Cepheid, and our clinical team in Nigeria and Memorial Sloan Kettering Cancer Center, we will analytically and technically validate the assay for future product development. Innovative approaches to increase early detection and decrease treatment delays of CRC can save thousands of lives in the many resource-poor areas of the world.

PI_NAMEs: SUKUMAR, SARASWATI  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: 2019-nCoV;Actins;Affect;Africa;African;Age;Aliquot;Asia;Attention;Benign;Biological Assay;biomarker panel;bisulfite;Blood Tests;Body mass index;Breast Cancer Detection;cancer biomarkers;cell free DNA;Cells;Cessation of life;Characteristics;Classification;Clinical;clinical practice;Clinical Research;Collaborations;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer screening;colorectal cancer treatment;commercialization;Communicable Diseases;Community Health;cost;Cost Savings;Data;Death Rate;Detection;detection assay;Development;Diagnosis;Diagnostic;diagnostic tool;Disease;DNA;DNA Methylation;DNA Modification Process;Early Diagnosis;Ensure;Equilibrium;financial toxicity;flu;Future;Genes;Goals;Hour;Hypermethylation;improved;Industrialization;industry partner;Infrastructure;innovation;Intervention;Knowledge;Laboratories;Lead;Lesion;liquid biopsy;low and middle-income countries;Malignant - descriptor;Malignant Neoplasms;Manuals;Measures;Memorial Sloan-Kettering Cancer Center;Methods;Methylation;methylation biomarker;Modification;Molecular;Nigeria;Oncology Group;Outcome;Pathology;Patient Care;Patient Selection;patient subsets;Patients;Performance;Persons;Plasma;point of care;point of care testing;Predictive Value;product development;programs;prospective;Prospective Studies;prototype;Publishing;rapid detection;rapid diagnosis;Reproducibility;Research;Resource-limited setting;Resources;Sampling;Sensitivity and Specificity;sex;Signs and Symptoms;Specificity;success;System;Technology;Testing;Tissues;Training;Triage;tumor;Tumor Subtype;underserved area;Validation

PROJECT_TITLE: Development of an automated, point of care DNA methylation cartridge blood test for colorectal cancer detection in LMICs- an academic-industrial partnership

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-S(57)R]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The Division of Rheumatology, Immunology and Allergy at Brigham and Women’s Hospital and this training grant vehicle provide the core that integrates basic and translational investigators across Harvard-affiliated institutions working in areas of basic biology, and translational and population sciences relevant to and focused in musculoskeletal and autoimmune rheumatic disease. Its goal is to provide an ongoing pipeline of select, highly trained and expert investigators prepared for and focused in rheumatic disease research.

PI_NAMEs: BRENNER, MICHAEL B. (contact);GRAVALLESE, ELLEN M

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TERMS: Disease;Immunologics;Rheumatism

PROJECT_TITLE: Immunologic Mechanisms and Rheumatic Diseases


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Epilepsy;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Genetic copy number variations (CNVs) play a causative role in neurodevelopmental disorders, increasing their risk by up to 30-fold. Although the biological effects of CNVs are not fully understood, we show that they produce abnormal excitability in neurons and circuits. We will use mouse and human cells to study the biological effects of a specific CNV on chromosome 16 and repurpose current anticancer and antiepilepsy drugs in an attempt to reverse the excitatory/inhibitory imbalance in human neurons with this CNV.

PI_NAMEs: PENZES, PETER  (contact);SAVAS, JEFFREY NICHOLAS

PROGRAM_OFFICER_NAME: DOSS, ARGENIA LANISHA NECOLE

PROJECT_TERMS: 16p11.2;Affect;Agreement;anti-cancer;anti-epileptic agents;Antineoplastic Agents;autism spectrum disorder;BIK gene;Bioinformatics;Biological;Brain;Cell membrane;Cells;Child;childhood epilepsy;Chromosome 16;Chromosomes;clinical phenotype;comorbidity;Complement;Complex;Copy Number Polymorphism;Data;Development;Disease;drug repurposing;Drug Targeting;effective therapy;Epilepsy;Equilibrium;Etiology;excitatory neuron;FDA approved;Future;Genes;Genetic;genetic architecture;Genomic DNA;Genotype;High Prevalence;Human;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitory neuron;innovation;insight;Intellectual functioning disability;Investigation;Ion Channel;Knowledge;Membrane;Mendelian disorder;Methodology;Modeling;Molecular;mouse model;multidisciplinary;Mus;network dysfunction;Neurobiology;Neurodevelopmental Disorder;neuronal excitability;Neurons;neuroproteomics;NIH Program Announcements;novel;novel strategies;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phenotype;Physiology;Play;Predisposition;Prevalence;Process;Property;protein protein interaction;Proteins;Proteome;Proteomics;receptor;Recurrence;Regulation;Relative Risks;Research;Risk;Risk Factors;Role;Seizures;Signal Transduction;Site;SNAP receptor;stem cell model;stem cells;superresolution imaging;superresolution microscopy;Synapses;Synaptic Receptors;Synaptic Transmission;Synaptosomes;Therapeutic;therapeutic development;trafficking;treatment strategy;Work

PROJECT_TITLE: Neuronal excitability and copy number variation disorders


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative This pre-doctoral student training program will develop ImmunoEngineering leaders of the future with the knowledge and skills in state-of-the-art immunology with application of engineering principles and the leadership skills to take prominent positions in ImmunoEngineering Academia and Industry.

PI_NAMEs: BABENSEE, JULIA E (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TITLE: T32 Research Training Program in ImmunoEngineering


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Opioid Misuse and Addiction;Opioids;Primary Health Care;Social Determinants of Health;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative Improving opioid use disorder outcomes depends not only on developing evidence-based treatments and prevention strategies, but also on optimizing the healthcare delivery and payment systems in which these interventions are deployed. Though value-based care is one of the most widespread healthcare delivery system innovations in the US today, large knowledge gaps remain in our understanding of whether – and how – these models promote better care quality for people with opioid use disorder. This career development award application proposes to use Massachusetts Medicaid accountable care organization implementation as a natural experiment to understand the effect of value-based care reform on quality of care and adequacy of reimbursement for opioid use disorder.

PI_NAMEs: HSU, HEATHER  (contact)

PROGRAM_OFFICER_NAME: WILEY, TISHA R  A

PROJECT_TERMS: accountable care organization;addiction;Address;Adopted;Advisory Committees;American;Applied Research;base;behavioral health;Benchmarking;beneficiary;Boston;care costs;care delivery;care providers;career;Caring;Cause of Death;Clinical;Community Surveys;comparison group;Complex;cost;Data;Diabetes Mellitus;disability;econometrics;Educational workshop;Effectiveness;effectiveness evaluation;efficacious treatment;Electronic Health Record;Enrollment;Ensure;evidence base;Evidence based intervention;Evidence based treatment;experience;Foundations;Funding;Goals;Group Practice;Health;health care delivery;health care model;health care quality;Health Care Reform;health economics;health management;Health Services Research;Health system;Healthcare;Healthcare Systems;Home;Homelessness;Hospitals;housing instability;Hypertension;improved;Incentives;Infectious Disease Epidemiology;innovation;Interruption;Intervention;K-Series Research Career Programs;Knowledge;Link;Managed Care Programs;Massachusetts;Measures;Medicaid;Medical;Medical center;medical schools;Medicine;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Modeling;National Institute of Drug Abuse;Natural experiment;Neighborhood Health Center;Neighborhoods;novel;opioid use disorder;Organizational Models;Outcome;Patient Care;Patient-Focused Outcomes;Patients;payment;Performance;Persons;Pharmacotherapy;Physicians;population health;Positioning Attribute;predictive modeling;Prevention strategy;primary outcome;Principal Investigator;Process;programs;Proliferating;Provider;Public Health;Quality of Care;Quasi-experiment;Research;Research Design;Research Personnel;Retrospective cohort study;Risk;Risk Adjustment;Risk Factors;safety net;Service delivery model;skill acquisition;skills;social;social health determinants;Strategic Planning;substance use;Substance Use Disorder;System;Time Series Analysis;Training;Treatment Efficacy;treatment strategy;United States;Universities;uptake

PROJECT_TITLE: Improving value-based healthcare delivery for opioid use disorder

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: ES

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative Bacterial and human hypermutations are essential for fitness in response to environmental challenges, but must be tightly regulated to avoid genetic chaos. The proposed research studies the regulation of error-prone DNA polymerase V, required to copy past DNA template lesions in Escherichia coli, which avoids cell death, and the regulation of activation-induced deoxycytidine deaminase (AID), which initiates somatic hypermutation required to generate antibody diversity in humans.

PI_NAMEs: GOODMAN, MYRON  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Affinity;Antibodies;Antibody Diversity;Antigens;Applications Grants;Asthma;ATP phosphohydrolase;B-Lymphocytes;Bacteria;Base Pairing;Biochemical;Catalysis;Cell Death;Cells;Cessation of life;Cryoelectron Microscopy;Deamination;deoxycytidine deaminase;design;DNA;DNA biosynthesis;DNA Damage;DNA polymerase V;DNA-dependent ATPase;Energy-Generating Resources;Ensure;Environment;environmental allergen;Enzymes;Escherichia coli;Exposure to;Fc Receptor;fitness;Fluorescence Resonance Energy Transfer;Frequencies;Generation of Antibody Diversity;Genetic;Genetic Transcription;high reward;high risk;Human;human DNA;IgE;Immune response;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;Individual;inhibitor;Ion Channel;Lesion;Location;Medical;Microscopy;Molecular Conformation;Monoclonal Antibodies;Mutation;novel;Organism;Oxygen;Pain;pain relief;Play;Polymerase;Production;Proteins;Pruritus;Rad30 protein;Reaction;receptor;recombinase;reconstitution;Regulation;research study;Resolution;response;RNA Polymerase II;Role;single molecule;Single-Stranded DNA;Stress;Structure;System;Testing;toxic industrial chemical;Tube;Ultraviolet Rays;Visualization

PROJECT_TITLE: Hypermutation in Bacteria and Humans


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Narrative (Public health relevance) This project will investigate whether introducing endothelial Sox13/17 will improve blood vessel adaptation to arterial environment. It has broad impact to vascular diseases where the homeostatic remodeling is impaired such as hyperplasia, stenosis, aneurysm, vein graft adaptation, as well as designing better tissue-engineered vascular grafts.

PI_NAMEs: DAI, GUOHAO  (contact);DARDIK, ALAN

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Adult;Anatomy;Aneurysm;Animal Model;arterial remodeling;Arteries;Biomechanics;Biomedical Engineering;Blood Vessels;calponin;clinical application;Coculture Techniques;Connexins;Data;decorin;design;Development;Developmental Biology;Diameter;differential expression;Disease;Elastin;Endothelial Cells;Endothelium;Environment;Ephrins;Exhibits;Extracellular Matrix;Family;Fistula;Gene Expression Profile;Genes;Genetic Transcription;hemodynamics;Human;Hyperplasia;Impairment;improved;In Vitro;in vivo;insight;Knowledge;Life;mechanotransduction;Mediating;Modeling;Molecular;Molecular Profiling;Molecular Target;mouse model;Mus;Muscle Cells;MYH11 gene;notch protein;overexpression;Pathologic;Pathway interactions;Periodicity;Phenotype;Physiology;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Play;Process;Production;programs;Property;public health relevance;reconstitution;recruit;Regulation;response;Role;Semaphorins;Series;Signal Transduction;Smooth Muscle Myocytes;SOX13 gene;SOX17 gene;Stenosis;Structure;System;Testing;Therapeutic Intervention;Thick;Tissue Engineering;transcription factor;Translating;Vascular Diseases;Vascular Graft;Vascular remodeling;vascular tissue engineering;Vein graft;Veins;Venous

PROJECT_TITLE: Role of endothelial Sox17 in EC-SMC crosstalk and homeostatic regulation of blood vessel adaption to arterial hemodynamics

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PI_NAMEs: HUTH, ALEXANDER  (contact);WEHBE, LEILA

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Address;Affect;Architecture;Area;Benchmarking;Brain;brain surgery;cognitive neuroscience;Computer Models;Computer software;Data;data integration;Data Set;data-driven model;Dependence;driving force;Epilepsy;experimental study;Fostering;Functional Magnetic Resonance Imaging;Goals;Health;Human;Human Characteristics;improved;in silico;innovation;insight;Instruction;Language;language impairment;language processing;Learning;Linguistics;Machine Learning;Maps;Methods;model building;Modeling;multitask;Names;natural language;Natural Language Processing;neural network;Neural Network Simulation;neuroimaging;Neurosciences;Participant;Patient-Focused Outcomes;post stroke;Productivity;Research;Research Personnel;Resolution;response;Running;Speech;Stimulus;Sum;System;targeted treatment;Techniques;Testing;Text;theories;therapy design;Training;transfer learning;tumor;Work

PROJECT_TITLE: CRCNS: Discovering Computational Principles of Language Processing in the Brain