NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Gene therapy with recombinant adeno-associated viral (rAAV) vectors provides the promise of curing inherited genetic disorders, however, it is challenges include the need to produce adequate amounts of rAAV to meet the needs of clinical trials and the poor efficiency of gene expression. Understanding the role of cellular proteins in replication of rAAV vector genomes will suggest ways to improve rAAV production and effective gene delivery. The studies proposed here seek to identify cellular proteins that associate with the AAV genome during replication in producer cells and transduction in target cells, and these results will lead to generation of resources to improve production and overcome current limitations.

PI_NAMEs: WEITZMAN, MATTHEW D. (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;adeno-associated viral vector;Adenoviruses;bioinformatics pipeline;Biological Assay;Cell Communication;Cells;Cellular Assay;chromatin immunoprecipitation;Clinical;Clinical Trials;confocal imaging;Coupling;Data;DNA;DNA biosynthesis;DNA Viruses;Environment;experience;Gene Delivery;gene delivery system;Gene Expression;gene therapy;Gene Transduction Agent;Generations;Genes;Genome;Goals;Helper Viruses;Hereditary Disease;Host Defense;Immunofluorescence Immunologic;improved;innovation;insight;Knowledge;Label;Mass Spectrum Analysis;Methodology;novel;overexpression;particle;Plasmid Cloning Vector;Plasmids;pre-clinical;Production;Proteins;Proteomics;Reagent;Recombinant adeno-associated virus (rAAV);Recombinants;recruit;Resources;RNA;Role;Serotyping;success;TCF3 gene;Techniques;Technology;Time;transduction efficiency;Transduction Gene;Transfection;vector;vector genome;Viral;viral DNA;Viral Genes;Viral Genome;Viral Packaging;Virus;Virus Replication

PROJECT_TITLE: Identifying cellular proteins associated with AAV genomes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ADMINISTERING_IC: DE

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Infectious Diseases;Microbiome

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Periodontal disease impacts millions globally. Our study focusses on the bacterium Veillonellae's role in oral health and its relationship with the periodontopathogen Porphyromonas gingivalis. This understanding could lead to novel treatments that enhance oral health and overall well-being.

PI_NAMEs: WU, CHENGGANG ;ZHOU, PENG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;Address;Altruism;Applications Grants;Bacteria;Bacterial Adhesins;Behavior;Biological Assay;Coculture Techniques;Cytolysis;Dancing;Data;dental biofilm;Dental Plaque;Ecology;Elements;Equilibrium;Erythrocytes;Gene Expression;gene regulatory network;Genes;Genetic Research;global health;Goals;Gram-Negative Anaerobic Bacteria;grasp;Growth;Heme;heme biosynthesis;Hemin;Hemolysis;Immune Evasion;Immune response;Immune system;In Vitro;in vitro Assay;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Iron;Libraries;Luciferases;member;mutant;Nature;novel;Nutrient;Operon;Oral;oral biofilm;Oral cavity;Oral health;oral microbial community;pathogen;Pathogenesis;Pathway interactions;Peptide Hydrolases;Periodontal Diseases;Periodontal Pocket;periodontopathogen;Personal Satisfaction;polymicrobial biofilm;Porphyromonas gingivalis;Process;Production;Proliferating;Proteins;receptor;Regulation;Regulator Genes;Reporter;Research;Resources;Role;Saliva;screening;Signal Pathway;Signaling Molecule;Source;Surface;Testing;theories;Time;Tissues;Tongue;tool;transcriptome sequencing;Veillonella;Veillonella atypica

PROJECT_TITLE: Hemin Production by Veillonella: A Novel Mechanism in Inhibiting P. gingivalis Hemolysis

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Disability Research;Health Services;Neurodegenerative;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE In this study, we will develop a refined rehabilitation toolbox that can be used to improve outpatient physical therapy service delivery for older adults with Alzheimer’s Disease and Related Dementias (ADRD). We need this study because current rehabilitation approaches do not address the unique needs of older adults with ADRD. Study findings will set a solid foundation for my future research and career as a leader in aging-focused rehabilitation research.

PI_NAMEs: MILLER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: Acceleration;Acute;Address;adverse outcome;Aging;Alzheimer disease screening;Alzheimer's disease related dementia;Award;career;Caring;Clinical;clinical practice;Clinical Trials Design;Cognitive;cognitive ability;cognitive disability;cognitive function;cognitive testing;Communities;Data;Data Analyses;Dementia;Development;disability;disability risk;Doctor of Philosophy;Early Diagnosis;Education;effectiveness testing;Epidemiology;evidence base;executive function;experience;fall injury;falls;Foundations;Future;Goals;Grant;Health;Health and Retirement Study;Health Services Research;Heterogeneity;hospital readmission;Hospitalization;human centered design;ideation;Impaired cognition;Impairment;implementation science;improved;Injury;innovation;instrumental activity of daily living;Intervention;Interview;K-Series Research Career Programs;Knowledge;Language;Leadership;Measures;Memory;Mentors;Morbidity - disease rate;mortality;National Institute on Aging;novel;Nursing Homes;older adult;Operative Surgical Procedures;Outcome;Outpatients;Patient Care;Patients;Physical Function;physical therapist;Physical therapy;Population;Pragmatic clinical trial;Prevalence;Protocols documentation;prototype;Provider;Qualitative Methods;Quality of life;Recording of previous events;Rehabilitation Outcome;rehabilitation research;rehabilitation service;Rehabilitation therapy;rehabilitative care;Reporting;Research Personnel;Research Training;Risk;screening;Screening procedure;service delivery;Services;Severities;skills;Solid;Testing;tool;Training;Uncertainty;United States National Institutes of Health;Visuospatial;Walking;Work;Writing

PROJECT_TITLE: Tailoring Rehabilitation to the needs of Older Adults with Cognitive Impairment and Dementia

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-6 (M1)]


ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

NIH_SPENDING_CATS: Aging;Cardiovascular;Dental, Oral, and Craniofacial Disease;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Infectious Diseases;Prevention

ORG_CITY: BETHLEHEM

ORG_NAME: LEHIGH UNIVERSITY

ORG_STATE: PA

PHR: Narrative Our proposed project will build upon previous research which has shown an association between oral health and systemic health, including the relationship between heart disease and periodontitis. We will benefit from recent methodological advances in computational genomics and be the first study to provide causal evidence about the postulated relationship between poor oral health and heart disease using nationally-representative, longitudinal data. Specifically, we will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model that are suitable for use in instrumental variables estimation. To accomplish our Aims, we will use longitudinal files containing 11 years of data (2006-2016) from the Health and Retirement Study (HRS). This longitudinal database will provide over 22,000 older Americans producing a sufficiently large sample size to overcome prior analytical obstacles.

PI_NAMEs: MEYERHOEFER, CHAD DELBERT (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Adult;Affect;Age;alveolar bone;American;Caring;Cessation of life;Chronic;Chronic Disease;Complex;Congestive Heart Failure;Control Groups;Coronary Arteriosclerosis;Data;Dental;dental biofilm;Dental Hygiene;Disease;Enrollment;Equation;Etiology;Excision;Exclusion;experimental study;Genetic;genetic information;Genetic Predisposition to Disease;genetic risk factor;Genetic Variation;genome wide association study;Genomics;Gingiva;Government;Health;Health and Retirement Study;Heart Diseases;Heritability;Home;human old age (65+);Immune system;improved;Individual;Infection;Inflammation;Injury;instrument;longitudinal database;Medical;Medicare;Mendelian randomization;Methodology;Methods;Modeling;Mouth Diseases;Myocardial Infarction;Nobel Prize;older adult;Older Population;Oral health;Outcome;Pathogenicity;Pathway interactions;Periodontal Diseases;Periodontitis;pleiotropism;Policy Analysis;Population;Prevalence;prevent;Preventive dental care;Probability;programs;Randomized;Randomized, Controlled Trials;Research;Risk Factors;Role;Sample Size;systemic inflammatory response;Tooth Loss;Tooth structure;treatment group;Twin Studies;unethical;Variant;Work

PROJECT_TITLE: Identifying the Role of Oral Health in Heart Disease through Integration of GWAS-by-Subtraction Genomic-Structural Equation Modeling with the Method of Instrument Variables

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (13)]


ADMINISTERING_IC: MH

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Eye Disease and Disorders of Vision;Mental Health;Neurosciences;Women's Health Research

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Proper integration of emotional and social information is essential for thriving and relies on the brain systems implicated in mental disease and often work differently in males and females, but the mechanisms of sex differences remain largely unknown. Based on a new paradigm for social synchronization in mice, this study tests a hypothesis that a female-specific alternative visual stream to the auditory fear circuit drives negative fear synchrony. The resulting basic knowledge will inform how the brain organizes even simple behaviors in a sex- specific manner using competing circuits.

PI_NAMEs: MOROZOV, ALEXEI  (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Amygdaloid structure;Animals;Attention;Auditory;auditory stimulus;Behavior;Behavioral;Brain;Cell Nucleus;cohesion;Conscious;Cues;designer receptors exclusively activated by designer drugs;Disease;Drops;early childhood;Emotional;Emotions;Empathy;Ensure;Facial Expression;Feeds;Female;Fostering;Freezing;Fright;Genetic;Gestures;Hippocampus;Human;Individual;Knowledge;Laboratories;Lateral;Lateral posterior nucleus of thalamus;Learning Skill;male;Mediating;Methods;midbrain central gray substance;mimicry;Mothers;Movement;Mus;Neurons;optogenetics;Outcome;Pathway interactions;Pattern;peer;Photic Stimulation;Physiology;Play;Positioning Attribute;Process;Property;Psyche structure;Puberty;response;Role;sex;Sex Differences;social;social attachment;Social Interaction;Speech;Stimulus;Stream;superior colliculus Corpora quadrigemina;Synapses;Synaptic plasticity;Synaptic Transmission;System;Testing;Testosterone;Unconscious State;Vision;Visual;visual information;Visual Pathways;visual stimulus;Work

PROJECT_TITLE: Sex Difference in the Integration of Visual Social Stimulus and Emotional Auditory Stimulus

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Disability Research;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Patient Safety;Prevention;Rehabilitation

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Community dwelling patients with dementia and their family caregivers represent a burgeoning and vulnerable population with significant unmet needs, one of which is pain management. The proposed study will refine and pilot test a novel non-pharmacological caregiver-assisted pain coping skills intervention to train patients and caregivers in skills to help them manage patient pain. The intervention is expected to benefit both patients and their caregivers by improving patient pain and quality of life and caregiver self-efficacy for managing pain, caregiver burden, and caregiving satisfaction.

PI_NAMEs: PORTER, LAURA S (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: acceptability and feasibility;Adherence;advanced disease;Agitation;Alzheimer's disease related dementia;arm;Behavioral;Benchmarking;Caregiver Burden;Caregivers;caregiving;Client satisfaction;Clinical;clinical care;clinical practice;Cognitive;Communities;community advisory board;Coping Skills;COVID-19 pandemic;Dementia;dementia care;design;disability;Disabling;Disease;Distress;Drug Interactions;Educational Intervention;Eligibility Determination;Enrollment;Ensure;Evaluation;fall risk;Family Caregiver;Feedback;future implementation;Health care facility;Impaired cognition;improved;indexing;Intervention;intervention delivery;intervention refinement;Interview;Learning;Length;Literature;Long-Term Care;Measures;Medical;meetings;member;Mental Health;mental state;neuropsychiatric symptom;Nonpharmacologic Therapy;novel;novel strategies;Nurses;older adult;Outcome;Pain;Pain management;Patient Care;Patient Education;Patient-Focused Outcomes;Patients;Persistent pain;Persons;Pharmacotherapy;physical conditioning;Physician Assistants;Pilot Projects;pilot test;Population;Positioning Attribute;Preparation;Prevalence;prevent pandemics;Procedures;Process;programs;Protocols documentation;psychological distress;psychosocial;Quality of life;randomized, clinical trials;recruit;Reporting;Research;response;retention rate;Risk;Role;Sample Size;satisfaction;Self Efficacy;Site;skills;skills training;Social Workers;Stress;Surveys;Testing;theories;United States;United States National Institutes of Health;Vulnerable Populations

PROJECT_TITLE: Caregiver-assisted pain coping skills training for dementia

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: PITTSBURGH

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Auditory-guided behavior is ubiquitous in everyday life. The deep layers of the auditory cortex gives rise to a major projection system that exerts brain-wide influence over many downstream regions, providing a putative substrate for such behavior. The proposed studies will monitor and manipulate this cortical output in awake, behaving mice, providing an important first step in understanding how corticofugal circuits govern animal behavior and insight into how descending contributions that may underlie sensory dysfunction.

PI_NAMEs: WILLIAMSON, ROSS STEWART (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Active Listening;Anatomy;Anesthesia procedures;Animal Behavior;Animals;Apical;Area;association cortex;Auditory;Auditory area;auditory categorization;auditory pathway;awake;Axon;Behavior;Behavioral;behavioral outcome;behavioral response;Brain;Brain region;Calcium;Categories;cell type;Cognitive;Corpus striatum structure;Data;Decision Making;Dendrites;design;flexibility;Functional disorder;Genetic;Goals;Head;Image;in vivo;Individual;Inherited;insight;Knowledge;Learning;Life;Mediating;Midbrain structure;Monitor;Morphology;Motor;Mus;Neocortex;neural;neural circuit;Neurons;novel;optogenetics;Output;Parietal Lobe;Pathway interactions;Physiological;Pilot Projects;Play;Population;Positioning Attribute;Process;Property;Research;response;Role;Route;Sensory;sensory cortex;sensory stimulus;Shapes;Signal Transduction;Source;Stimulus;Structure;System;Techniques;Testing;transmission process;two-photon;Viral;Work

PROJECT_TITLE: Extratelencephalic contributions to auditory categorization

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative The structure of brain ECM is dynamically regulated by experience and plays a critical role in neuronal plasticity and behavior. However, how the brain’s ECM is structured, maintained, and remodeled is poorly understood, in part due to the limitation of tools that monitor the structural heterogeneity and dynamics of the brain’s ECM. Using a novel live-cell imaging probe that we developed, we will identify neuronal ECM organizers and reveal the regulatory process of the brain’s ECM.

PI_NAMEs: PARK, SUNG JIN  (contact);ZELIKOWSKY, MORIEL

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Aging;Amygdaloid structure;animal old age;Antibodies;Architecture;Behavior;Brain;brain based;brain volume;cell type;Cells;Collagen;Color;conditioned fear;Diffuse Pattern;End Point Assay;excitatory neuron;experience;Extinction;Extracellular Matrix;fear memory;flexibility;Fluorescence;Foundations;Fright;Functional disorder;Gel;Genetic;genetic manipulation;Glycoproteins;Goals;Heterogeneity;Hyaluronan;Image;imaging probe;In Vitro;in vivo;Individual;insight;Interneurons;interstitial;Knowledge;Label;Lectin;Ligands;Link;link protein;live cell imaging;loss of function;Mediating;memory consolidation;Memory Loss;Modeling;Molecular;Monitor;Names;neuronal cell body;Neuronal Plasticity;Neurons;novel;novel strategies;Parvalbumins;Pattern;Peripheral;Play;Polysaccharides;Population;Process;Proteoglycan;recruit;Regulation;Role;scaffold;Specificity;Structure;sugar;Surface;Tissues;tool;Visualization

PROJECT_TITLE: Revealing the extensive structural features and regulatory process of the brain’s ECM

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Our selection of foods we consume is governed in large part by taste pathways in the periphery (sweet, salty, sour, etc). However, there is a paucity of information about the molecular identities of afferent sensory neurons that process taste signals and transmit these signals to the brain. Understanding how basic tastes are encoded by sensory neurons whose molecular profiles are known is key for understanding diet selection and making rational choices of what we eat.

PI_NAMEs: CHAUDHARI, NIRUPA ;ROPER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Afferent Neurons;Auditory;biomarker validation;Brain;Brain Stem;Categories;Cell Communication;Cell Nucleus;cell type;Cells;Cephalic;Chromium;Code;combinatorial;Data;designer receptors exclusively activated by designer drugs;Detection;Diet;Eating;Electrophysiology (science);Entropy;Feeding behaviors;food consumption;Food Selections;Funding;Ganglia;Gene Expression Profile;Genetic;Genomics;glucose tolerance;Goals;Image;in vivo;Insulin;Label;Laboratories;Lasers;Measures;Mediating;Methods;Molecular;molecular marker;Molecular Profiling;Mouse Strains;Mus;Neural Pathways;Neurons;Noise;nutrition;Pathway interactions;Phase;Physiological;Process;prototype;Reflex action;response;Reticular Formation;Retina;Retinal Ganglion Cells;Signal Transduction;single-cell RNA sequencing;somatosensory;Stimulus;Structure of geniculate ganglion;System;Taste Bud Cell;Taste Buds;Taste Perception;taste stimuli;Testing;transcriptome;transmission process;Visual

PROJECT_TITLE: Functions of gustatory afferent neuron types.

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: AUSTIN

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE  The descending auditory efferent pathway may be involved in supra-threshold hearing, but a comprehensive understanding of how the efferent system develops in humans is lacking. The proposed work will investigate the development of the temporal aspects of efferent mechanisms in children. It is clinically and scientifically relevant, as the knowledge gained can be used to develop objective tests for assessing auditory function, guide intervention efforts and may be applied for designing hearing devices.

PI_NAMEs: MISHRA, SRIKANTA  (contact)

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TERMS: 12 year old;Acoustics;Adult;Affect;Age;Algorithms;Audiology;Auditory;Auditory Perception;auditory processing;Auditory system;Biological Assay;Brain Stem;Child;Childhood;Clinical;cochlear synaptopathy;Code;Communication;Complex;Contralateral;Data;design;Development;developmental plasticity;Device Designs;Efferent Pathways;Environment;Exhibits;experience;Feedback;Frequencies;Goals;Hearing;Hearing Aids;Human;improved;infancy;innovation;insight;Intervention;Ipsilateral;Knowledge;Language Development;Life;Measurement;Measures;Medial;Modeling;neural;Noise;noise exposure;Noise-Induced Hearing Loss;novel;Outcome;Outcome Study;Peripheral;Play;Population;Predisposition;Principal Investigator;Public Health;Research;response;Role;signal processing;Signal Transduction;sound;Speech;Speech Perception;Stimulus;System;Techniques;Testing;theories;Time;Work

PROJECT_TITLE: Development of medial efferent mechanisms in children


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PUBLIC HEALTH RELEVANCE Recent studies have uncovered the existence of at least 16 mechanistically distinct forms of regulated cell death, and commonly used anti-cancer drugs have the ability to activate many, if not all, of these pathways. Understanding which forms of cell death are activated by a drug is critical for predicting mechanisms of drug resistance and for improving drug efficacy; however, this information is not currently known due to the lack of tools needed to simultaneously evaluate all types of cell death. This proposal aims to develop new tools to enable a comprehensive evaluation of which forms of cell death are activated by a drug, and how these features vary across patients, disease types, and treatment contexts.

PI_NAMEs: LEE, MICHAEL JUNGHO (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Address;Animal Model;Antineoplastic Agents;ANXA5 gene;Apoptosis;Apoptotic;Binding;Biochemical;Biochemical Markers;Biological Markers;cancer type;CASP3 gene;Cell Death;cell type;Cells;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;Coupled;Custom;Data;Dependence;design;Development;Disease;Dose;drug action;Drug Combinations;drug efficacy;Drug Evaluation;Drug Kinetics;drug mechanism;Drug resistance;Environment;Evaluation;experimental study;Failure;Future;Genetic;genetic profiling;genome-wide;Goals;Growth;Histone Deacetylase Inhibitor;improved;In Vitro;in vivo;in vivo evaluation;Individual;insight;Knock-out;Libraries;Location;Measures;Mediating;Methods;Modeling;mouse model;Necrosis;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;pharmacologic;Population;pre-clinical;Property;public health relevance;random forest;Regulation;Reporting;Resolution;response;response biomarker;Rupture;Sampling;Signal Transduction;specific biomarkers;Techniques;Testing;Therapeutic;Thinking;Time;tool;Toxic effect;triple-negative invasive breast carcinoma;tumor;Variant

PROJECT_TITLE: Characterization of drug mechanisms of lethality in vivo

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Prevention;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE This proposal will characterize the role of the gut microbiome in susceptibility to the human pathogen Shigella flexneri, which causes the disease shigellosis. Our research will identify bacterial strains that may be protective against disease and yield candidate probiotics. Additionally, we will define gut bacterial pathways involved in protection against Shigella pathogenesis.

PI_NAMEs: WOLF, ASHLEY ROBIN (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Adult;Aerobic;Antibiotic Resistance;Antibiotics;Automobile Driving;Bacteroides fragilis;Cessation of life;Child;Clinical Trials;Clostridium difficile;Coculture Techniques;Collection;Communities;Complex;Country;Data;diarrheal disease;Disease;Dose;Epithelial Cells;Escherichia coli;experimental study;fecal transplantation;Food Contamination;Future;gastrointestinal;Germ-Free;Growth;gut bacteria;gut microbiome;high risk population;Human;Human Microbiome;human pathogen;humanized mouse;Immunity;in vitro Model;Individual;Infection;Inflammasome;interest;intestinal epithelium;Invaded;Knowledge;Laboratories;Literature;Measures;Mediating;Metabolic Pathway;metagenomic sequencing;microbial;microbiome;microbiome research;mouse model;Multi-Drug Resistance;Mus;novel;novel therapeutic intervention;Oral;Participant;pathogen;Pathogenesis;Pathway interactions;Persons;Predisposition;prevent;Prevention;Probiotics;prophylactic;Regimen;Research;Resistance;resistance mechanism;resistant Shigella;resistant strain;Resources;Role;Route;Salmonella;Sampling;Sanitation;Shigella;Shigella flexneri;Shigella Infections;stool sample;Streptomycin;Symptoms;Testing;Therapeutic;Time;transmission process;Transplantation;United States;vaccine access;Vibrio cholerae;Virulence;Vulnerable Populations

PROJECT_TITLE: Defining human gut microbiome-mediated protection against Shigella infection

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Hearing Loss;Mental Health;Neurodegenerative;Neurosciences;Rehabilitation

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Sensorineural hearing loss (SNHL) affects nearly 50% of adults over the age of 60 and has a profoundly negative effect on speech comprehension, leading to increased social isolation, reduced quality of life, and increased risk for the development of dementia in older adulthood. The studies in our proposal use combined pupillometry and cognitive event-related brain potentials to characterize the effects of listening effort on comprehension and memory functioning in older adults with and without hearing loss. If successful, this project will lead to the identification of objective and reliable neural markers of comprehension and memory processes impaired by SNHL, leading to better future clinical assessment and the improved design of evidence-based interventions to improve speech comprehension and memory in aging.

PI_NAMEs: PAYNE, BRENNAN  (contact)

PROJECT_TERMS: Acoustics;Address;Adopted;Adult;Affect;Age;age related;Aging;Area;Attention;Audiology;Award;Brain;career;Chronic;clear speech;Clinical;Clinical assessments;clinically relevant;Cognitive;cognitive neuroscience;Comprehension;cost;Data;Dementia;design;Development;Electrophysiology (science);Event;evidence base;Evidence based intervention;experience;experimental study;Extramural Activities;Foundations;Funding;Future;Goals;Health;hearing impairment;Impairment;improved;innovation;insight;Intervention;Knowledge;Language;language processing;Literature;Measures;Memory;memory process;Methods;Mydriasis;National Institute on Deafness and Other Communication Disorders;neural;Neurocognitive;neuromechanism;Noise;novel;older adult;Performance;Phonetics;Physiological;Prevalence;Process;Psycholinguistics;Public Health;Quality of life;Research;Research Priority;Resources;response;Retrieval;Risk;Semantics;Sensorineural Hearing Loss;Social isolation;specific language impairment;Speech;speech in noise;Speech Perception;speech processing;syntax;Testing;Time;Voice;Work

PROJECT_TITLE: Understanding the effects of listening effort on sentence processing and memory in sensorineural hearing loss: Evidence from simultaneous electrophysiology and pupillometry

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Clinical Research;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Hearing and balance disorders affect millions of people worldwide, yet the underlying damage patterns in the ear are not understood well for many inner ear-related clinical problems. This project will develop a large human temporal bone collection as a resource for the scientific community to investigate the inner ear correlates of hearing and balance problems in a diverse population. The project will also refine methods for rapid processing of newly obtained temporal bones and create a multi-platform imaging and analysis pipeline for maximization of the information obtained from each specimen.

PI_NAMEs: CAREY, JOHN PATRICK;LAUER, AMANDA M. (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Academic Medical Centers;Acceleration;Address;Adopted;Affect;African American population;Age;Aging;analysis pipeline;Animal Disease Models;Arachnoid mater;Auditory;Autopsy;Baltimore;bilingualism;Biological;Brain;Brain Stem;Catalogs;Childhood;Clinical;Cochlea;Collaborations;Collection;Communication;Communities;Consent;cost;crowdsourcing;Data;Databases;Decalcification;Democracy;demographics;digital;Disease;Ear;Ear Diseases;Education;Education and Outreach;education resources;Educational Materials;Enrollment;Ensure;epidemiology study;equilibration disorder;Equilibrium;Equipment;Facial nerve structure;Faculty;Funding;Goals;Harvest;Health;Hearing;Hearing problem;Hematoxylin and Eosin Staining Method;Histology;Human;Image;imaging platform;Improve Access;Information Dissemination;Infrastructure;inner ear diseases;Intention;Knowledge;Laboratories;Laboratory Finding;Laboratory Research;Labyrinth;Longitudinal Studies;macula;Measures;Medical;Medical Illustration;meetings;Melanins;Meniere's Disease;Mentors;microCT;Modernization;Nature;nerve supply;Neurosciences;nonhuman primate;novel;Online Systems;otoconia;Otology;outreach;Participant;Pathology;Pattern;Persons;Population Heterogeneity;Population Study;Postdoctoral Fellow;pre-doctoral;Presbycusis;preservation;Prevalence;Process;programs;Proliferating;Protocols documentation;rapid technique;reconstruction;Recording of previous events;recruit;Research;Research Personnel;Resources;response;Role;Scientist;Semicircular canal structure;sex;Sickle Cell Anemia;Slide;Specimen;Stains;Students;Techniques;Temporal bone structure;Testing;Time;timeline;Tissues;tool;Training;training opportunity;transcriptomics;Uncertainty;Underrepresented Populations;Underrepresented Students;Vestibular Diseases;Vestibular function;vestibular system;Visualization;Work;working group

PROJECT_TITLE: Johns Hopkins Human Temporal Bone Resource


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE Evaluating interventions that consider both social communication and disruptive behavior strategies is critical for children with autism spectrum disorder (ASD) who have challenges in both domains, which limit a family's participation in everyday activities. Understanding when, in what sequence, and how best to teach parents to use social communication and disruptive behavior interventions is critical to reducing family burden and increasing the efficiency and efficacy of each intervention. Developing and evaluating interventions for children with ASD supports NIDCD's mission of behavioral research aimed to support social communication in children with ASD.

PI_NAMEs: ROBERTS, MEGAN Y (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 9 year old;adaptive intervention;adult with autism spectrum disorder;Affect;Age Months;autism spectrum disorder;autistic children;Behavior;Behavior Therapy;behavioral outcome;Behavioral Research;Characteristics;Child;Communication;Communication difficulty;cost;design;Development;Diagnosis;Disruptive Behavior Disorder;Early identification;Educational process of instructing;Exhibits;Family;family burden;Feedback;Frequencies;Goals;implementation intervention;improved;in vivo;Individual;Instruction;Intervention;Joints;Learning;Life;Link;Manuals;Measures;Mediating;Mediator;Methods;minimally verbal;Mission;Modeling;National Institute on Deafness and Other Communication Disorders;Outcome;parenting intervention;Parents;Play;Prevention;Randomized;randomized trial;Research;Role;Sequential Multiple Assignment Randomized Trial;skills;social communication;social learning;teacher;trial design

PROJECT_TITLE: Optimizing Outcomes through Sequencing Parent-Mediated Interventions for Young Children with Autism

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because it maximizes the biological information from human biospecimens by creating a comprehensive multi-omic platform that results in genotype to phenotype analysis that will be used in diagnostics for personalized medicine and target identification for drug discovery. A multi- omics extraction methodology combined with pathway analysis software will increase the rate of biomarker discovery, which will allow early identification of sensitive individuals, provide biomarkers of responsiveness to therapy, and new drug targets and thereby therapeutic agents. The proposed research is relevant to the part of NIH’s mission that pertains to developing fundamental knowledge and technology that will help reduce and treat disease.

PI_NAMEs: MACDONALD, JEFFREY M. (contact);MIECZKOWSKI, PIOTR ANDRZEJ;SCOTT, WILLIAM K

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Acids;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acids;Animals;Autolysis;Autopsy;Biochemistry;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Body Temperature;Brain;Brain Diseases;brain research;brain tissue;Categories;Cause of Death;Cells;Cessation of life;Computer software;Cryopreservation;data acquisition;Data Analyses;data quality;Databases;Disease;DNA;drug discovery;Early identification;Ethics;Etiology;Freezing;Future;Genes;Genomics;Genotype;Goals;Heterogeneity;Hippocampus;Human;human tissue;Individual;Ischemia;Knowledge;Laboratories;Lipase;lipidome;lipidomics;Lipids;Location;macromolecule;Measures;metabolome;metabolomics;Methodology;Methods;Microanatomy;Mission;Molecular;multiple datasets;multiple omics;Neurodegenerative Disorders;Neurologic;new technology;new therapeutic target;Nonesterified Fatty Acids;North Carolina;novel;Nucleus Accumbens;Outcome;Pathway Analysis;Pathway interactions;Pentas;personalized diagnostics;personalized medicine;Phenotype;Phospholipids;Procedures;Process;Proteins;Proteome;Proteomics;Public Health;Quality Control;rapid test;Regulation;Reporting;repository;Research;Ribonucleases;Ribosomes;Risk;RNA;Sampling;standard measure;Technology;Testing;Therapeutic Agents;Time;tissue resource;Tissue Sample;Tissues;tool;transcriptomics;Translations;United States National Institutes of Health;Universities;Validation

PROJECT_TITLE: Validation of penta-omic assays in brain tissue and identification of markers of tissue and -omic data quality

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Neurosciences;Rehabilitation

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The goal of this research is to better understand the efferent auditory system’s role in speech-in-noise perception by: 1) improving methods used to study it and 2) evaluating its function in normal-hearing adults with and without speech-in-noise deficits. The outcomes of this research can be used to: 1) create clinical assessments and targeted treatments for individuals with severe difficulties understanding speech-in-noise and 2) create biologically-inspired noise reduction algorithms for hearing aids and cochlear implants that are based on neural processing strategies in the normal auditory system.

PI_NAMEs: SMITH, SPENCER  (contact)

PROJECT_TERMS: Academic achievement;Acoustic Nerve;Active Listening;Adult;Algorithms;Amplifiers;Animals;Attention;attentional modulation;Auditory;auditory pathway;Auditory system;base;Biological Assay;Biophysics;Brain;brain computer interface;Brain Stem;Clinical;Clinical assessments;Cochlea;Cochlear Implants;Cognitive;Communication impairment;Contralateral;Development;experimental study;Frequencies;Glean;Goals;Hearing Aids;Hearing Tests;Human;Impairment;improved;Individual;Labyrinth;Lesion;Light;Measurement;Measures;Mechanics;Medial;Methods;Modeling;Nervous System;neural;neural circuit;Neurobiology;neurophysiology;Noise;noise perception;normal hearing;otoacoustic emission;outcome disparities;Outcomes Research;Outer Hair Cells;Patients;Perception;Performance;personalized diagnostics;Physiological;Play;predictive test;Proxy;Reflex action;Research;Research Project Grants;response;Role;Signal Transduction;Site;social;Speech;speech in noise;Speech Perception;speech processing;standard measure;Statistical Models;Stimulus;Structure of tractus olivocochlearis;System;targeted treatment;Time;treatment strategy;Vocation;Withdrawal;Work

PROJECT_TITLE: Efferent Auditory Measurements during Continuous Attended Speech in Normal Hearing Listeners With and Without Speech-in-Noise Deficits


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative  The goal of this study is to employ Bayesian inference to design subject-specific models of voice production for norm and structural vocal pathologies. The proposed models utilize high-speed videoendoscopy, electroglottography, and acoustic data for parameter inference and model validation. The vocal dynamics, glottal aerodynamics and their interactions are studied comprehensively using the computational models to better understand the normal and disordered function of voice.

PI_NAMEs: NAGHIBOLHOSSEINI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Adult;Affect;Air Movements;Area;Award;Bayesian Analysis;Bayesian Modeling;Bayesian Prediction;Behavior;Biomechanics;Biophysical Process;Characteristics;Communication;Complex;Computer Models;Coupled;Coupling;Data;design;Diagnosis;Disease;Edema;efficacy evaluation;Elements;Functional disorder;Future;Goals;Health;Human;human data;Hybrids;improved;in vivo;Individual;kinematics;Kinetics;Knowledge;Laryngitis;Larynx;Liquid substance;Lung;Measurement;Methods;model design;Modeling;National Institute on Deafness and Other Communication Disorders;Nature;Noise;Normal Range;novel strategies;Operative Surgical Procedures;Oral cavity;Outcome;Outcome Study;Outcomes Research;Parameter Estimation;Participant;Pathologic;Pathology;Patients;Pattern;Phonation;Polyps;predictive modeling;Prevention;Probability;Production;Property;Research;Research Personnel;Signal Transduction;simulation;Speed;Strategic Planning;Structure;System;Techniques;Tissues;tool;Treatment Efficacy;Uncertainty;Validation;vibration;vocal cord;Voice;Voice Disorders

PROJECT_TITLE: Bayesian Data-Driven Subject-Specific Modeling of Voice Production


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cerebrovascular;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: The proposed research is relevant to public health because it will create a widely accessible tool for alleviating an immense neurological burden in brain cancer patients, i.e. seizures induced by brain tumors. This research is relevant to the NIH’s mission, and in particular the mission of NINDS because it will transform how scientists can study seizures occurring in a brain cancer microenvironment, generate fundamental knowledge about the neurobiology of the seizure-brain tumor nexus, and pave the way for physicians to test new synergistic anti-seizure/anti-tumor therapeutics.

PI_NAMEs: PATHAK, ARVIND P;SENARATHNA, DANAPALA M. M. JANAKA (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 3D Print;Address;Anesthesia procedures;Anesthetics;Animals;Anticonvulsants;awake;Behavior;Blood flow;Blood Vessels;Brain Neoplasms;Cancer Patient;Cell Proliferation;Cerebrovascular Circulation;Clinical;Clinical Management;Clinical Research;clinically relevant;cloud based;cohort;Computer software;Data;data acquisition;design;Development;Electroencephalography;Fluorescence;Functional Magnetic Resonance Imaging;Glioma;Goals;Halorhodopsins;hemodynamics;Hour;hypoperfusion;Hypoxia;Image;imaging modality;Imaging technology;Impact Seizures;Implant;in vivo;in vivo imaging;Induced Neurons;insight;Internet;Invaded;Knowledge;Laser Speckle Imaging;Lighting;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;meter;Microscope;miniaturize;Mission;Modeling;Motion;Mus;National Institute of Neurological Disorders and Stroke;neoplastic cell;Neurobiology;neuroimaging;Neurologic;Neurons;neurovascular coupling;neurovascular unit;novel;Optics;optogenetics;Patients;Physicians;Physiological;Physiology;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;preclinical imaging;preclinical study;Proliferating;prototype;Public Health;Quality of life;radiation resistance;remote control;Research;Resistance;Resolution;Scientist;Seizures;Severities;Signal Transduction;Specificity;Stream;Structure;Technology;Testing;Therapeutic;Time;tool;Treatment Efficacy;tumor;Tumor Cell Invasion;tumor growth;tumor microenvironment;tumor progression;two-photon;United States National Institutes of Health;Variant;Work;Xenograft procedure

PROJECT_TITLE: NeuroVu: A Novel Cloud-based Microscope for Remote Neurosurveillance of the Seizure-Brain Tumor Nexus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hearing Loss;Pediatric;Prevention;Rehabilitation

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

PHR: Project Narrative (Relevance) Hearing loss, including deafness, poses obstacles to children's language development and social relationships. This project employs innovative, longitudinal modeling of objectively measured naturalistic behavior to investigate young children's vocal interactions in preschool, and the influence of those interactions on their language development. The project will indicate whether understudied processes of peer- and teacher-influenced language development differ between children with hearing loss and their typically hearing preschool peers over months and years. These efforts will pave the way for classroom-based interventions to enhance the language development of children with hearing loss and other children with language delays.

PI_NAMEs: MESSINGER, DANIEL S (contact);PERRY, LYNN K

PROJECT_TERMS: 2 year old;3 year old;4 year old;Affect;Age;Age Months;automated analysis;Behavior;Behavioral;Biological Assay;biological sex;Child;Child Development;Child Language;Cochlear implant procedure;Cochlear Implants;cohort;Competence;Complex;Computer Models;cost;Data;data de-identification;deafness;design;Development;Developmental Process;Early Intervention;Enrollment;Exposure to;Fertile Period;Growth;Hearing;Hearing Aids;hearing impairment;Impairment;improved;indexing;Individual;Individual Differences;innovation;Intervention;Language;Language Delays;Language Development;Life;Location;Measurement;Measures;Mediating;Modeling;Movement;multilevel analysis;Nursery Schools;Oral;Participant;Pattern;peer;Physics;Positioning Attribute;Process;Quality of life;Reproducibility;Role;Sampling;scaffold;Schools;Severities;social;social contact;Social Development;Social Interaction;social relationships;societal costs;Socioeconomic Status;Speech;Speech Development;Standardization;Statistical Models;teacher;temporal measurement;Testing;Time;tool;Veins;vocalization

PROJECT_TITLE: Language Development and Social Interaction in Children with Hearing Loss

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Prevention

PI_NAMEs: ACHARYA, BIBHAV  (contact);SAPKOTA, SABITRI

PROGRAM_OFFICER_NAME: VEDHAM, VIDYA

PROJECT_TERMS: acceptability and feasibility;Address;Adverse effects;Advocacy;Advocate;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;anxiety reduction;Awareness;Behavior;behavior test;Behavior Therapy;Behavioral;Belief;Breathing;Caregiver Burden;caregiver stress;Caregiver support;Caregivers;Chronic;cognitive capacity;cognitive function;Communities;Community Health Aides;Community Services;comorbidity;Country;Cues;Deceleration;Dementia;dementia care;Diabetes Mellitus;Disease;Disease Progression;Disparate;Effectiveness;evidence base;Face;Feedback;Frequencies;functional improvement;Future;Goals;Guidelines;Health Benefit;Health Services Accessibility;Hypertension;Impaired cognition;improved;Income;Infrastructure;Intervention;intervention refinement;Interview;low and middle-income countries;Manuals;Mental Depression;Mental disorders;Mental Health;Methods;mild cognitive impairment;Morbidity - disease rate;mortality;motivational enhancement therapy;multidisciplinary;Nepal;neuropsychiatric symptom;parent project;Parents;Patients;Persons;Pharmaceutical Preparations;Physical activity;Pilot Projects;Play;Polypharmacy;preference;Quality of life;Recommendation;Respiratory Diaphragm;Risk;Role;side effect;skills;Smoking;stress reduction;Structure;Surveys;Symptoms;Testing;Work

PROJECT_TITLE: Adapting evidence-based behavioral interventions to address non-communicable diseases and common mental health conditions among people with dementia or mild cognitive impairment


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Hearing Loss;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Hearing disorders such as tinnitus, presbycusis, and noise-induced hearing loss are incredibly common and have long been recognized as public health epidemics. This project employs novel strategies to identify how feedback loops between high and low-level auditory centers contribute to hearing, which could eventually inspire new treatments for hearing disorders. More broadly, similar feedback loops occur across all sensory systems; these studies thus lay the conceptual groundwork to understand a general principle of mammalian sensory perception and higher-order brain function.

PI_NAMEs: APOSTOLIDES, PIERRE F (contact)

PROJECT_TERMS: Acoustics;Active Listening;Address;Anatomy;Anesthesia procedures;Animals;Apical;Auditory;Auditory area;auditory discrimination;auditory pathway;auditory processing;Auditory system;awake;Behavioral;Behavioral Assay;Biophysical Process;Brain;Brain Stem;Cognition;Cognitive;Complex;Data;Dendrites;Detection;Discrimination;discrimination task;Epidemic;Event;experience;experimental study;Feedback;Frequencies;Generations;Glutamates;Goals;Head;Hearing;hearing impairment;Hearing problem;Image;improved;In Vitro;Inferior Colliculus;Knowledge;Learning;Light;Linguistics;Link;Mediating;Midbrain structure;Mus;neuronal cell body;Neurons;Noise-Induced Hearing Loss;novel strategies;operation;optogenetics;Outcome;Output;Pathway interactions;Perception;Perceptual learning;physical property;Play;Presbycusis;prevent;Public Health;Quality of life;Rewards;Role;segregation;Sensory;sensory system;Shapes;Signal Transduction;sound;Speech;Stimulus;Stream;Synapses;Testing;Time;Tinnitus;transmission process;two-photon;Work

PROJECT_TITLE: Dendritic Mechanisms Underlying Behaviorally-Relevant Activity in a Descending Auditory Pathway


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Rare Diseases;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), or other disorders can become unable to move or speak despite being awake and alert. In this project, we seek to further translate knowledge about interpreting brain signals related to movement, and to further develop an intracortical brain-computer interface (iBCI) that could restore rapid and intuitive use of communication apps on tablet computers by people with paralysis.

PI_NAMEs: HOCHBERG, LEIGH R (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: alternative communication;Amyotrophic Lateral Sclerosis;arm;Augmentative and Alternative Communication;awake;Brain;brain computer interface;BRAIN initiative;Brain Stem Infarctions;Calibration;Caregivers;Clinical Research;Clinical Trials;Collaborations;Communication;communication device;Competence;Computer software;Computers;Darkness;Data;deep learning;design;Detection;Development;Devices;Dimensions;Disease;expectation;experience;Family;Fatigue;feasibility trial;Feedback;first-in-human;flexibility;Friends;Gestures;Hand;Home;Human;Human Activities;Implant;improved;Individual;Industry;Injury;innovation;Institution;Intention;Interactive Communication;Intuition;Knowledge;Language;Lighting;Location;Locked-In Syndrome;long short term memory;Methods;Modeling;Modernization;Motor;Motor Cortex;motor disorder;motor impairment;Movement;Mus;National Institute on Deafness and Other Communication Disorders;neural;neural implant;Neurons;neuroregulation;nonhuman primate;novel;Outcome Measure;Paralysed;Participant;Pattern;Performance;Persons;phrases;preference;Research;Research Support;Residual state;Signal Transduction;Speech;Speed;Surveys;System;Tablet Computer;Tablets;Technology;Testing;Time;tool;Touch sensation;touchscreen;Translating;Translations;two-dimensional;United States National Institutes of Health;wireless

PROJECT_TITLE: Intuitive, complete neural control of tablet computers for communication


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

PHR: Project Narrative  Discovering mechanisms to enhance adult brain function is of utmost importance when devising therapeutics to recover and refine normal brain function later in life. We found that temporarily depriving vision leads to recovery of plasticity in the adult auditory cortex, which can benefit auditory function. In this proposal, we aim to determine the mechanisms that allow recovery of adult brain plasticity, and whether temporary visual deprivation improves auditory performance in adults.

PI_NAMEs: KANOLD, PATRICK O;LEE, HEY-KYOUNG  (contact)

PROJECT_TERMS: Adult;Affect;Area;Auditory;Auditory area;auditory processing;auditory thalamus;Automobile Driving;Behavior;Behavioral;behavioral outcome;Blindness;Brain;Cell Nucleus;Cells;Chemosensitization;Cochlear Implants;critical period;Data;Detection;Development;discrimination task;Disinhibition;Environment;Excitatory Synapse;experience;Feedback;Hearing;Image;improved;in vivo;information processing;Injury;insight;Lateral;Life;Mediating;Modality;Mus;Nerve Degeneration;Neurons;Neurophysiology - biologic function;novel;Operative Surgical Procedures;Organ;Patients;Performance;Peripheral;Population;postnatal development;Prognosis;Publishing;receptive field;Recovery;Recovery of Function;Regulation;Reporting;Research;response;Role;Sensory;Signal Transduction;sound;Source;speech recognition;Stimulus;Stroke;success;Synapses;Testing;Thalamic structure;Therapeutic;therapy development;Time;Tinnitus;two-photon;Vision;Visual;visual deprivation;Visually Impaired Persons;vocalization;Work

PROJECT_TITLE: Cross-modal enhancement of auditory plasticity and performance in adults


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Immunotherapy;Liver Cancer;Liver Disease;Microbiome;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Gut microbiota may play a role in the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC). We will follow patients with MASLD-related HCC treated with immunotherapy to assess the impact of gut microbiome and host susceptibility in the disease progression and response to immunotherapy. Our long-term goal is to improve dismal survival rates in HCC patients and to develop a new method of intervention and strategy to complement current clinical efforts focused on personalized and effective care for MASLD-related HCC.

PI_NAMEs: JALAL, PRASUN KUMAR (contact)

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Adverse event;anti-PD-L1;Asia;B-Cell Activation;bevacizumab;Biological Assay;Blood;Blood specimen;Cancer Center;Caring;CCL20 gene;Cell Proliferation;checkpoint therapy;chronic liver disease;circulating biomarkers;Cirrhosis;Clinic Visits;Clinical;Collaborations;Collection;college;Complement;Core Facility;curative treatments;Development;Diagnosis;Disease Progression;dysbiosis;Enrollment;Europe;Excision;experience;Exposure to;Feces;follow-up;Future;Genes;Genetic Markers;Genotype;Goals;gut dysbiosis;gut microbiome;gut microbiota;Hepatic;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C virus;Hepatobiliary;Histologic;Immune;Immune checkpoint inhibitor;Immunotherapy;improved;Incidence;Inflammatory;Institutional Review Boards;Intervention;Intestinal permeability;Lead;Liver diseases;liver transplantation;macrophage-derived chemokine;Medicine;Metabolic dysfunction;Metabolic syndrome;Methods;microbial;microbiome;microbiome alteration;microbiome signature;microbiota;microbiota composition;microbiota profiles;Migration Inhibitory Factor;Modality;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Participant;Patient Recruitments;Patient-Focused Outcomes;Patients;personalized approach;phase III trial;Pilot Projects;Plasma;Population;predicting response;Predisposition;Prevalence;Prevention;Primary carcinoma of the liver cells;Process;Prognosis;prognostication;Progression-Free Survivals;protein biomarkers;Proteins;Protocols documentation;Public Health;Research;Research Infrastructure;response;Risk;Role;Sampling Studies;Southeastern Asia;Steatohepatitis;stool sample;stromelysin 2;success;Survival Rate;Testing;Texas;Therapeutic;Time;Treatment outcome;tumor;tumor-immune system interactions;United States;University of Texas M D Anderson Cancer Center;Variant;whole genome;Whole-Genome Shotgun Sequencing

PROJECT_TITLE: CROSSTALK BETWEEN GUT MICROBIOTA AND HEPATOCELLULAR CARCINOMA INDUCED BY METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE  The human genome and that of its experimental surrogate, the mouse, contain an estimated 20,000 genes. Studying these genes has traditionally involved modifying the mouse genome on a gene-by-gene and study-by- study basis. The proposed experiments are designed to accelerate the development and decrease the cost of mouse genome studies, moving strain development efforts from a gene-by-gene method to a more massively parallel approach.

PI_NAMEs: BERGSTROM, DAVID ERIC (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Ablation;Acceleration;animal resource;Animals;base editing;blastocyst;Cell Line;Cells;chromosomal location;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Communities;Complex;Consumption;cost;CRISPR/Cas technology;Development;DNA;DNA Modification Process;DNA Sequence;Elements;embryonic stem cell;Event;Experimental Designs;experimental study;Funding;Generations;Genes;Genome;genome analysis;genome editing;genome-wide;Germ Cells;Guide RNA;Haploidy;Health;Heart;HSV-Tk Gene;Human;Human Genome;in vivo;Individual;International;Knock-out;Knockout Mice;LacZ Genes;Methods;Microinjections;Modification;mouse development;Mouse Embryonic Stem Cells;mouse genome;Mus;Nature;new technology;novel;nuclease;Oocytes;Pharmaceutical Preparations;Plasmid Cloning Vector;Ploidies;prime editing;prime editor;Process;Proteins;recombinase;Reporter;Resistance;Resources;Reverse Transcription;RNA-Directed DNA Polymerase;Site;Specificity;System;Technology;technology development;Testing;Thymidine Kinase;Time;Toxin;zygote

PROJECT_TITLE: Rapid Development of Mouse Resource Strains through the Application of Prime Editors

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Many Latinas with untreated depression and/or anxiety do not get the care they need. This study compares a choice-driven, interactive, evidence-informed storytelling web-based app intervention with links to resources and local treatment recommendations, to a web-based app with links to publicly available informational internet videos, resources, and a local treatment locator for at least moderately anxious/depressed untreated English and Spanish speaking Latinas to determine if a story-based, character-driven approach is more effective for catalyzing mental health treatment initiation. Knowledge gained about drivers of action will expand strategies to connect Latinas to sources of needed treatment via our scalable web-based app for low cost.

PI_NAMEs: HEILEMANN, MARYSUE V (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: 2 arm randomized control trial;Age;Anxiety;anxiety symptoms;anxious;Appointment;arm;Attitude;Back;Behavior;behavior change;California;Caring;Cellular Phone;Clinic;comparison control;Computers;Consent;Control Groups;cost;culturally appropriate intervention;Data;Data Analytics;Data Collection;Depressed mood;depressive symptoms;Diagnosis;digital platform;Distress;distrust;effectiveness evaluation;efficacy testing;Electronic Health Record;Electronic Mail;Emotions;evidence base;experience;feasibility testing;Film;follow-up;Health;Health Resources;help-seeking behavior;Insurance;Internet;Intervention;intervention effect;Knowledge;Latina;Latina Population;Latino;Latinx;Latinx population;Lead;Link;Major Depressive Disorder;Mediating;Mediation;Mediator;Medical;Medical Records;men;Mental Depression;Mental Health;Mental health promotion;Mental Health Services;multidisciplinary;Nurses;Participant;Pharmacotherapy;pilot test;Planning Theory;Procedures;psychoeducation;psychologic;psychological distress;Randomized, Controlled Trials;Recommendation;Reporting;Research;Resources;Risk;Role;role model;Sampling;Site;social cognitive theory;social culture;social media;social stigma;Source;Spanish;Spanish/English;Suicide;Surveys;Symptoms;Tablets;Testing;Text;Trust;United States;video chat;web app;web site;White Women;Woman

PROJECT_TITLE: Randomized controlled trial of a choice-driven, interactive, storytelling web-based app to investigate mental health treatment initiation among symptomatic Latinas

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE This proposal aims to investigate the mechanisms underpinning the role of the Forkhead domain transcription factor, Foxp2, in the development of the inferior olive in mice. The research outcomes will deepen our understanding of how mutations in different FOXP2 proteins lead to a spectrum of cognitive disorders in humans.

PI_NAMEs: LI, JAMES Y.H (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Adult;Alleles;Atlases;autism spectrum disorder;Automobile Driving;Brain region;Cell Aggregation;cell motility;Cell Nucleus;cell type;Cells;Cerebellar Cortex;Cerebellum;Chromosome Mapping;Cognition Disorders;cognitive process;Complex;cost effective;Data;Development;Disease;disease prognosis;DNA Sequence Alteration;Embryo;Fiber;FOXP2 gene;Gene Expression;Gene Expression Alteration;Heterogeneity;hindbrain;Human;human tissue;imaging study;Individual;Inferior;innovation;insight;intercellular communication;Intervention;Knowledge;Label;language impairment;Lead;Measures;Mediating;Medulla oblongata olive;Mental association;Mental disorders;Molecular;mosaic nature;Motor;Mus;Mutation;neuroimaging;Neurons;novel strategies;Olives - dietary;Outcomes Research;Output;Pattern;personalized medicine;Play;Pontine structure;protein profiling;Proteins;Purkinje Cells;Regulation;Research;Resolution;Role;Schizophrenia;single-cell RNA sequencing;Synapses;System;Testing;therapeutic development;tool;transcription factor;transcriptome;transcriptomics;treatment response;Variant

PROJECT_TITLE: Molecular Mechanisms and Heterogeneity in the Inferior Olivary Nucleus Development


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Lung;Organ Transplantation;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth;Transplantation

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This proposal is focused on establishing the safety, feasibility, and accessibility of a remotely delivered exercise-focused intervention to treat frailty in candidates for lung transplantation. This focus directly addresses areas identified by the National Heart Lung and Blood Institute as key priorities to advancing lung transplant clinical care and research.

PI_NAMEs: SINGER, JONATHAN PAUL (contact);SMITH, PATRICK JOSEY

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: acceptability and feasibility;Address;Age;American;Anxiety;Area;Behavior;behavior change;Behavior Therapy;Behavioral;Biological Markers;Cardiovascular system;Cessation of life;Chest;Clinical;clinical care;Clinical Management;Clinical Research;Communities;Computer software;Consensus;Data;design;Development;disability;disability risk;drug development;effectiveness trial;effectiveness/implementation hybrid;efficacy study;efficacy testing;efficacy trial;European;Evaluation;Event;Exercise;exercise adherence;Exercise Physiology;exercise program;exercise training;experience;frailty;Geriatrics;Goals;Guidelines;Habilitation;health literacy;health related quality of life;Heart Transplantation;Home;Hospitalization;Hospitals;improved;inclusion criteria;innovation;International;Intervention;intervention program;Intervention Studies;Intervention Trial;Interview;Lead;Life Style;Life Style Modification;lifestyle intervention;Lung Diseases;Lung Transplantation;Measures;meetings;Mental Depression;Modeling;modifiable risk;mortality;motivational enhancement therapy;multidisciplinary;National Heart, Lung, and Blood Institute;novel;Obesity;older adult;Operative Surgical Procedures;Organ Transplantation;Outcome;Outpatients;Oxygen;Participant;Pathway interactions;patient engagement;Patient Outcomes Assessments;Patient Representative;Patient Selection;Patients;Perioperative complication;Phase;Physical activity;Physical Function;Population;Positioning Attribute;post-transplant;Postoperative Period;Preparation;primary outcome;Professional Organizations;prognostic;programs;Protocols documentation;psychologic;Psychological Factors;Pulmonary Hypertension;pulmonary rehabilitation;Qualifying;Randomized;Recommendation;recruit;Rehabilitation therapy;Relaxation;remote delivery;remote intervention;Reporting;respiratory;Risk;Risk Factors;risk stratification;Safety;sarcopenia;satisfaction;Science;screening;Self Efficacy;Seminal;Series;Societies;Solid;standard of care;systemic inflammatory response;telehealth;Testing;therapy design;Training;Translating;Transplant Recipients;Transplantation;trend;United States National Institutes of Health;videoconference;Visit;Waiting Lists;Walking;Work

PROJECT_TITLE: XFIT: An Exercise-based Frailty Intervention in Lung Transplant Candidates

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-F (M2)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Rehabilitation;Substance Misuse;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project narrative: Excessive use of prescribed opioids during and after major surgery is a significant contributor to persistent opioid use, misuse and ongoing opioid epidemic, which are recently worsened by the pandemic. The proposed research has significant public health relevance because it aims to reduce surgical pain and opioid use with a promising non-pharmacological tool, digital cognitive behavioral intervention, that helps decrease anxiety and depression before surgical procedures. By proactively reducing mood disorder (anxiety, depression) severity, postoperative surgical pain, opioid use and opioid-related serious adverse effects with digital cognitive behavioral intervention, this research will enable the best-in-class post-surgical pain and opioid-related outcomes in millions of Americans undergoing painful surgeries every year while minimizing the nation's opioid epidemic burden.

PI_NAMEs: CHELLY, JACQUES E. (contact);KAYNAR, A. MURAT

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Adverse effects;adverse outcome;Affect;American;Anxiety;anxiety reduction;anxious;Blinded;Cellular Phone;Cessation of life;Chronic;chronic pain;chronic pain patient;Chronic pain syndrome;chronic painful condition;Client satisfaction;Clinical Trials;Cognitive Therapy;comparison intervention;cost;COVID-19 pandemic;Data;Dependence;depressed patient;Development;digital;digital applications;digital delivery;Dose;Effectiveness;evidence base;experience;fighting;Guidelines;Head;high risk;Hip region structure;hip replacement arthroplasty;improved;Inflammatory Bowel Diseases;innovation;knee replacement arthroplasty;Knowledge;Length;Mental Depression;Mental Health;Mood Disorders;morphine equivalent;multidisciplinary;Nonpharmacologic Therapy;novel;Operative Surgical Procedures;Opioid;opioid epidemic;opioid mortality;opioid sparing;opioid tapering;opioid use;opioid use disorder;Oral;Orthopedic Surgery;Outcome;Overdose;overdose death;Pain;pain catastrophizing;Pain management;pain relief;pandemic disease;Patient Schedules;Patients;Perioperative;Positioning Attribute;Postoperative Pain;Postoperative Period;prescription opioid;Procedures;Property;prospective;psychologic;public health relevance;Randomized;Research;Resources;Risk;Risk Factors;Role;Safety;Severities;standard of care;Statutes and Laws;Substance Use Disorder;substance use treatment;success;surgical pain;Symptoms;Techniques;Technology;telehealth;Telemedicine;Testing;Time;tool;Traction;treatment duration;trend;Work

PROJECT_TITLE: Telemedicine-delivered digital cognitive behavioral intervention to decrease post-operative opioid use among patients undergoing total knee and hip arthroplasty

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: In Hirschsprung disease (HSCR), we have just completed whole genome sequencing of 766 unrelated HSCR cases, their 99 affected and 1,293 unaffected first-degree relatives. Here, we use state-of-the-art genomic and functional analysis to enable a near complete genetic characterization of HSCR by improved detection of all variant types in coding and cis regulatory elements of known and novel genes. In addition, using other available genetic data, we test whether HSCR genes contribute to the risk of associated neurocristopathies, to explain the wide spectrum of HSCR phenotypes.

PI_NAMEs: CHATTERJEE, SUMANTRA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Affect;Alleles;ATAC-seq;Base Sequence;biobank;Cell Line;Child;Code;Computer Simulation;Congenital diaphragmatic hernia;Congenital Heart Defects;Congenital Megacolon;Copy Number Polymorphism;Data;Data Analyses;database of Genotypes and Phenotypes;Databases;de novo mutation;Defect;Detection;Development;developmental disease;Disease;disease phenotype;Disease susceptibility;DNase I hypersensitive sites sequencing;Down's Syndrome;Embryo;Enteral;Enteric Nervous System;Epispadias;Esophageal Atresia;exome;Exons;Fibrinogen;First Degree Relative;Frequencies;Gastrointestinal tract structure;Gene Expression;Gene Frequency;gene regulatory network;Genes;Genetic;Genetic Heterogeneity;Genome;genome sequencing;Genomics;Grant;Heritability;Heterogeneity;Histones;Human;improved;Incidence;Individual;insertion/deletion mutation;Intestines;Introns;Kidney;Length;Literature;Machine Learning;male;Methods;Molecular;Multifactorial Inheritance;Mus;Neural Crest Cell;Neuroblastoma;novel;Nucleotides;Odds Ratio;Parents;Pathogenesis;Pathogenicity;Penetrance;Population Attributable Risks;proband;programs;Proliferating;promoter;Proteins;Quality Control;Regulatory Element;Risk;Risk Factors;RNA Splicing;Sampling;segregation;sex;Signal Transduction;Site;Susceptibility Gene;Testing;Trans-Omics for Precision Medicine;transmission process;United States National Institutes of Health;Variant;whole genome

PROJECT_TITLE: Computational identification of Hirschsprung disease susceptibility genes

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Disability Research;Physical Rehabilitation;Prevention;Rehabilitation;Wound Healing and Care

ORG_CITY: Los Angeles

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT SUMMARY Diabetic foot ulcers (DFUs), which often lead to disability, reduced quality of life, and amputation, require offloading foot pressure during walking to prevent recurrence after healing. However, many patients struggle to follow the recommended offloading treatment. Thus, we propose a lifestyle-focused occupation therapy (OT) intervention to help patients develop self-care routines and habits that support consistent offloading.

PI_NAMEs: TAN, TZE-WOEI  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: academic standard;acceptability and feasibility;Address;Adherence;Affect;Amputation;Area;behavioral health;Caring;Cessation of life;Clinical;Complications of Diabetes Mellitus;Control Groups;Coping Skills;cost;cost-effectiveness evaluation;Data;Development;diabetes distress;Diabetes Mellitus;diabetic;Diabetic Foot;Diabetic Foot Ulcer;Direct Costs;disability;Dropout;Education;Effectiveness;Enrollment;environmental adaptation;Evaluation;experience;Feasibility Studies;Focus Groups;foot;Goals;group intervention;Habits;healing;Health;health care service utilization;health related quality of life;high risk;high risk population;Hispanic;improved;Individual;innovation;interdisciplinary collaboration;Intervention;Interview;Knowledge;Life Style;lifestyle intervention;lifetime risk;Limb Salvage;Limb structure;Lower Extremity;Measures;Mentored Patient-Oriented Research Career Development Award;Methods;mortality risk;Neuropathy;Occupational Therapist;Occupational Therapy;Occupations;Outcome;Outcome Measure;Participant;participant interview;patient oriented;Patient Outcomes Assessments;patient population;Patients;Persons;Physical Function;physical impairment;Pilot Projects;Play;Population Heterogeneity;pressure;prevent;Prevention;Provider;psychosocial;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recurrence;recurrence prevention;Research Personnel;Resources;retention rate;Risk;Role;routine care;satisfaction;Schedule;Self Care;Societies;Surveys;System;Telephone;Therapeutic;Therapeutic Intervention;Ulcer;United States;Visit;Walking

PROJECT_TITLE: Evaluating the Feasibility and Acceptability of a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers: A Pilot Study

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Prevention;Stroke

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: This project aims to look at targeting neuroinflammation to prevent cerebral vasospasm after subarachnoid hemorrhage. This project will contribute to the application of knowledge to enhance health, lengthen life, and reduce illness and disability among subarachnoid hemorrhage patients to prevent ongoing morbidity and mortality. Project Narrative

PI_NAMEs: HOH, BRIAN LIM;HOH, BRIAN LIM (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Aneurysmal Subarachnoid Hemorrhages;Behavior;Behavioral;behavioral outcome;bench to bedside;Biological Markers;catalyst;Cell Death;Cerebral Ischemia;Cerebrospinal Fluid;Cerebrovascular Spasm;Clinical Trials;Data;Development;disability;first-in-human;Funding;Health;Hospitalization;Hospitals;Human;Hydrocephalus;IL-6 inhibitor;Image;improved;Inflammatory;Inflammatory Response;Interleukin-6;Investigation;Journals;Knowledge;Laboratories;Life;Link;Microglia;Molecular;Morbidity - disease rate;mortality;Mus;neuroinflammation;Neurologic;Oxidative Stress;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Phase II Clinical Trials;PLEKHG5 gene;pre-clinical;prevent;Prevention;Publications;Publishing;Receptor Signaling;Ruptured Aneurysm;Sampling;Seminal;Subarachnoid Hemorrhage;Time;Toll-like receptors;Training;Vasospasm

PROJECT_TITLE: Satralizumab as a Treatment for Aneurysmal Subarachnoid Hemorrhage (the STASH Trial)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative  This project proposes to establish paradigm-changing geometric deep learning models to uncover tissue domains coherent in both histology and gene expression and enable automated prediction of pathology from single-cell spatially resolved transcriptomics (SRT) tissue samples. As SRT is anticipated to revolutionize the study of cellular biology, this new modeling paradigm will have a transformative impact on the computation and machine learning methods for SRT analyses.

PI_NAMEs: GAO, SHOU-JIANG ;HUANG, YUFEI  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: 3-Dimensional;Adopted;Algorithms;Alveolus;Attention;Awareness;Bar Codes;Biological;Cell model;Cell Physiology;Cells;Cellular biology;Cellular Structures;Classification;commercialization;Complex;computerized tools;COVID-19;COVID-19 patient;Data;Data Analyses;Data Set;deep learning;deep learning model;design;Disease;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Geometry;Goals;Graph;graph neural network;Heterogeneity;Histology;imaging Segmentation;in situ sequencing;Individual;innovation;insight;Learning;learning strategy;Location;machine learning method;Measurement;Measures;Methods;Modeling;Molecular;Molecular Profiling;neural network;neural network algorithm;Neural Network Simulation;novel;Pathologic;Pathology;Pattern;Performance;Physiological;Pneumonia;Positioning Attribute;Process;Regional Disease;Reporting;Resolution;Semantics;single cell technology;Spottings;Structure;Structure of parenchyma of lung;Technology;Testing;Tissue Model;Tissue Sample;Tissues;Training;Transcript;transcriptomics

PROJECT_TITLE: Novel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics data

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cardiovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Hypertension;Infant Mortality;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases;Substance Misuse;Sudden Infant Death Syndrome;Women's Health Research

ORG_CITY: BOCA RATON

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

PHR: Project Narrative The aims of this study are to: (1a) estimate the extent of comorbidities among pregnant women with prenatal alcohol exposure; (1b) build maternal morbidity risk profiles based on social and behavioral determinants of health among women with prenatal alcohol intake using machine learning (ML) methods; (2a) examine the effects of comorbidities on adverse birth outcomes among alcohol-exposed pregnancies; and 2(b) build risk profiles for adverse birth outcomes using ML methods. This study presents a model of study that combines both maternal and infant health in the context of maternal-fetal exposure to alcohol, using innovative methods of data analyses that will yield previously unidentified risk profiles. Given the need for careful allocation of scarce health care resources for prevention and treatment programs, the identification of women and their infants for adverse health outcomes most at risk is critical. .

PI_NAMEs: KITSANTAS, PANAGIOTA  (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;adverse birth outcomes;Affect;alcohol abstinence;Alcohol consumption;alcohol consumption during pregnancy;alcohol effect;alcohol exposure;Alcohols;Behavioral;binge drinking;Birth;Brain;Cardiac;Cardiovascular Diseases;Child;classification trees;Clinical;comorbidity;Confidence Intervals;Congenital Abnormality;congenital anomaly;Data;Data Analyses;Decision Trees;design;Developmental Delay Disorders;Diabetes Mellitus;drinking;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Health;health determinants;Healthcare;Heavy Drinking;High Prevalence;high risk;high risk population;Hypertension;Infant;Infant Health;Infant Mortality;Infection;Injury;innovation;Intervention;large datasets;Lead;Logistic Regressions;Machine Learning;machine learning method;Maternal and Child Health;maternal comorbidity;Maternal Health;maternal morbidity;Medical;medical complication;Mental Depression;Mental disorders;Methods;Monitor;Morbidity - disease rate;Mothers;Obesity;Odds Ratio;offspring;Outcome;Overweight;Persons;Play;Population;population based;Population Research;Pre-Eclampsia;Pregnancy;pregnancy hypertension;Pregnant Women;premature;prenatal;prenatal exposure;Prevention program;Public Health;public health priorities;Reporting;Research;Resources;Risk;Risk Assessment;Role;Science;screening;Screening procedure;Septic Toxemia;Small for Gestational Age Infant;social;Social Controls;Source;Statistical Methods;stillbirth;Study models;Sudden infant death syndrome;System;Target Populations;Techniques;Translating;treatment program;Woman

PROJECT_TITLE: Comorbidities in Pregnant Women with Prenatal Alcohol Exposure and Adverse Birth Outcomes

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative Connexin channels mutations cause deafness, blindness, dermatological and neurological disorders, and developmental diseases. We seek to develop a nanobody tool kit that help us to study connexin channels role in normal biology and pathology.

PI_NAMEs: CONTRERAS, JORGE ENRIQUE (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Affinity;Affinity Chromatography;Amyotrophic Lateral Sclerosis;Antibodies;Antibody titer measurement;Applied Research;Arrhythmia;Astrocytes;Atherosclerosis;B-Lymphocytes;Bacteria;Bacteriophages;Basic Science;Behavior;Biology;Blindness;Brain Ischemia;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell membrane;Cells;Chronic Kidney Failure;Code;Communication;Communities;Connexin 43;Connexins;Cytoplasm;Data;deafness;Dermatologic;Development;developmental disease;Diabetes Mellitus;Disease;disease model;Disease Progression;Docking;Duchenne muscular dystrophy;Engineering;Ensure;Enzyme-Linked Immunosorbent Assay;Epitopes;extracellular;Extracellular Domain;Fab Immunoglobulins;fluorophore;Functional disorder;gap junction channel;Genetic;Genetic Engineering;genetic manipulation;Germ Cells;Glutamates;Goals;Health;Hela Cells;Human;Hyperactivity;Hypertension;Immunization;Immunize;immunocytochemistry;Immunofluorescence Immunologic;immunogenicity;in vitro activity;in vivo;inhibitor;innovation;intercellular communication;Intrabody;Ions;Length;Libraries;Literature;Liver Failure;Llama;Mediating;Modeling;Molecular;mouse model;Mutation;myocardial injury;N-terminal;nanobodies;natural antibodies;Nervous System Disorder;neurotoxicity;Organ;Pathologic;Pathology;Penetration;Peptides;peptidomimetics;Permeability;Phage Display;pharmacologic;Physiological;Physiology;Play;prevent;Production;Protein Isoforms;Proteins;Protomer;Recombinants;Reporting;response;RNA;RNA Sequences;Role;screening;Serum;Signal Transduction;Sorting;Source;Specificity;Spinal cord injury;Stress;Stroke;Structure;System;Technology;Therapeutic Intervention;Tissues;tool;Western Blotting;willingness;Xenopus oocyte

PROJECT_TITLE: Development of a nanobody tool kit to study connexin channels

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Bipolar Disorder;Brain Disorders;Depression;Genetics;Mental Health;Mental Illness;Neurosciences

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Relevance Mutations in LRRC57, an evolutionarily conserved gene of unknown function, have been identified among the top hits in bipolar disorder studies. Here we propose to identify the biochemical function of LRRC57 and characterize its role in neural excitability, synaptic plasticity, cognition, and bipolar disorder–related behaviors.

PI_NAMEs: ZAKHARENKO, STANISLAV S (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Affect;Animals;Antibodies;antibody engineering;Atlases;Behavior;Behavioral Assay;Biochemical;Biology;Bipolar Disorder;Brain;Caenorhabditis elegans;Cell Line;Cell membrane;Cell Proliferation;Cell Survival;Cells;Chronic;Cognition;Cognition Disorders;cognitive function;cognitive testing;Complex;conditional knockout;Cre driver;Data;Defect;depressive symptoms;Development;Disease;Drosophila melanogaster;Electrophysiology (science);Embryo;Etiology;excitatory neuron;experimental study;fly;FlyBase;Foundations;Functional disorder;gene conservation;Genes;Genetically Engineered Mouse;genome wide association study;genomic locus;Germ Lines;Growth Factor;Hippocampus;Homologous Gene;Human;human disease;Immunochemistry;insight;knock-down;Knock-out;Knockout Mice;Learning;Leucine-Rich Repeat;Lifestyle-related condition;Lipids;Literature;LoxP-flanked allele;Manic;Mediating;Memory;Mental Depression;Mental disorders;Messenger RNA;Molecular Profiling;Moods;mRNA Expression;Mus;Mutant Strains Mice;Mutation;N-Myristoylation;Nervous System Disorder;neural;Neural Crest;Neurites;neurodevelopment;Neurons;neurophysiology;Neurophysiology - biologic function;neuropsychiatric disorder;Neurosecretory Systems;neurotrophic factor;Oryctolagus cuniculus;overexpression;Persons;Physiological;Population;Population Study;postnatal;Preparation;preservation;pressure;presynaptic;Presynaptic Terminals;Prosencephalon;Proteins;Public Health;Recurrence;Reporting;response;Rodent;Role;Shapes;Signal Transduction;Slice;suicidal risk;Synapses;synaptic function;Synaptic plasticity;Synaptic Transmission;System;Tail;Testing;Tissues;tool;Transgenic Mice;Western Blotting;Work;WormBase

PROJECT_TITLE: LRRC57 modulates neurotrophic growth factor signaling in synaptic function and behavior

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Dietary Supplements;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: MADISON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Central nervous system (CNS) injuries result in severe disability or death partly due to lack of axon regeneration in CNS neurons. This proposal uses a recently developed method of purifying CNS neurons that regenerate axons after injury, from those that do not. Coupled with established high-throughput single-cell methylomic and transcriptomic protocols, this approach provides a unique opportunity to distinguish molecular profiles specifically associated with regenerating neurons and unique to select neuronal subtypes, and how a known neuroprotective and pro-regenerative molecule (folic acid) alters the regenerative capacity of specific cell subtypes.

PI_NAMEs: ALISCH, REID SPENCER;ISKANDAR, BERMANS J (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Axon;axon injury;axon regeneration;Biochemical;Biochemical Pathway;Blindness;Brain;Brain Diseases;Cell Separation;cell type;Cells;Central Nervous System;central nervous system injury;Cessation of life;Characteristics;Coupled;differential expression;disability;DNA Methylation;DNA methylation profiling;Environment;Exhibits;Eye;Failure;Folic Acid;folic acid supplementation;Gene Expression;Genes;Genetic Transcription;improved;Injections;Injury;Intervention;Methods;Methylation;methylomics;Modeling;Molecular;Molecular Profiling;Natural regeneration;Nerve Degeneration;Nervous System Disorder;neuron regeneration;neuronal cell body;neuronal survival;Neurons;neuroprotection;novel;Ophthalmoscopy;Optic Nerve;Optic Nerve Transections;Optics;Paralysed;Pathway interactions;Peripheral Nerves;permissiveness;Population;Predisposition;Protocols documentation;Publishing;rat genome;Rattus;regenerative;Regenerative capacity;Reporting;Research;resilience;response;retinal ganglion cell regeneration;Retinal Ganglion Cells;Spinal Cord;Spinal Diseases;Stroke;System;Testing;Tissues;transcriptome sequencing;transcriptomics;Trauma;whole genome

PROJECT_TITLE: Defining folate-dependent single-cell methylomic and transcriptomic networks in distinct retinal ganglion cell types associated with axon regeneration


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE The identification and quantification of low-abundance and post-translationally modified proteins is a formidable and unmet challenge with tremendous potential to impact human health. The proposed research will develop a new chemical platform employing N-heterocyclic carbenes and gold nanoparticles to improve the ionization efficiency of peptides, which is critical for elucidating protein structure. This increased sensitivity has the potential to reveal new disease biomarkers and provide a protein-level view of cellular functions.

PI_NAMEs: CAMDEN, JON  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Adoption;Alkynes;Amino Acids;Ammonium;Azides;Benchmarking;Biochemical;Biological Markers;biomarker identification;carbene;Cell Physiology;cellular imaging;Chemicals;Chemistry;Coupled;Darkness;Detection;detection limit;Disease;Electrospray Ionization;experimental study;Gases;Genes;Goals;Health;high reward;high risk;Human;human genome sequencing;improved;instrumentation;ionization;Label;Lasers;Length;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Methods;Modeling;Modernization;Modification;nanoGold;Peptide Fragments;Peptides;Phase;Post-Translational Protein Processing;Process;protein structure;Proteins;Proteome;Proteomics;Research;Route;Salts;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Sulfhydryl Compounds;Surface;System;Tissues;tool;Variant

PROJECT_TITLE: Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Burden of Illness;Chronic Pain;Disability Research;Neck Pain;Pain Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: Project Narrative  Neck pain is a highly prevalent condition that leads to considerable pain, disability, and economic burden. Despite the clinical significance of neck pain, limited treatment options are available and often ineffective or unsafe. In this project, we will develop a wireless soft electronics-enabled smart transdermal microneedle patch to manage neck pain by integrating electronic devices with therapeutic microneedles.

PI_NAMEs: JIN, LI ;LI, XUDONG J.;XU, BAOXING  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Analgesics;Animals;Anti-Inflammatory Agents;Area;Back;Behavior;Biocompatible Materials;Biological Assay;Cadaver;Cellular Phone;Clinical;clinically relevant;clinically significant;Computers;cost;Data;data communication;data exchange;design;Development;Devices;Dextrans;Diffusion;disability;disability burden;disability-adjusted life years;Drug Delivery Systems;Drug Kinetics;Drug Modelings;Economic Burden;economic cost;efficacious treatment;Electronics;Encapsulated;Equipment;Evaluation;experimental study;Feedback;Film;fluorescein isothiocyanate dextran;Gastrointestinal tract structure;Goals;Gold;Health Care Costs;Heating;Hemorrhage;Ibuprofen;Immobilization;immunoreaction;in vivo;in vivo imaging system;Inflammation;Injury to Kidney;Label;Lidocaine Patch;liver injury;manufacture;Mediating;Metabolism;Modeling;Molecular;Monitor;Motion;multimodality;Neck;Neck Pain;Needles;non-opioid analgesic;Non-Steroidal Anti-Inflammatory Agents;novel;Opiate Addiction;Oral;Oral Administration;Overdose;Pain;Pain in lower limb;Pain management;pain model;pain relief;patient oriented;Pattern;Penetration;Persons;Pharmaceutical Preparations;phase change;Positioning Attribute;Posture;Power Sources;Process;Production;Rattus;Reader;Resistance;Risk Reduction;Route;Safety;sensor;Sick Leave;side effect;Silicon;Site;Skin;skin barrier;Skin Temperature;Slipped Disk;Stratum corneum;Structure;Surface;System;Temperature;Testing;Therapeutic;Time;Time Management;Tissues;Ulcer;Validation;wireless;wireless electronic

PROJECT_TITLE: A soft electronics-enabled smart microneedle patch for neck pain management

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The goal of this application is to enhance the ability of the Johns Hopkins University Center for AIDS Research (CFAR) to nurture and support high-impact HIV research and researchers across a broad range of disciplines and specialties in the multiple divisions of this major research university. The CFAR will recruit, mentor and support new investigators, including members of underrepresented population groups, provide research support services, and leverage the capacity of Johns Hopkins to help end the HIV epidemic in Baltimore and nationally.

PI_NAMEs: CHAISSON, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: WONG, ELAINE WAI-KEN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS prevention;Area;Award;Baltimore;base;Bioinformatics;Biological Assay;career;Career Mobility;Cities;Clinical;Clinical Pharmacology;Clinical Research;Collaborations;collaboratory;combat;Communication;Communities;community based research;community building;community intervention;community organizations;community partnership;Consultations;data sharing;Development;Discipline;District of Columbia;Electronic Mail;Epidemic;epidemic preparedness;ethnic disparity;experience;Extramural Activities;Faculty;Foundations;Funding;Future;Generations;Goals;Government Agencies;Grant;Health;health disparity;Historically Black Colleges and Universities;HIV;HIV Infections;HIV/AIDS;Immunology;Individual;Information Dissemination;innovation;Institution;instrument;interdisciplinary collaboration;Interest Group;Investments;Laboratories;Leadership;Link;medical schools;medical specialties;Medicine;meetings;member;Mentors;Methods;Mid-Atlantic Region;Minority-Serving Institution;Mission;Modeling;multidisciplinary;Newsletter;next generation;Pathway interactions;Pilot Projects;Population;Population Group;Positioning Attribute;Preparation;Prevention;Productivity;programs;Public Health;Public Health Schools;Publications;racial disparity;recruit;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Risk;Role;Scholars Program;School Nursing;Science;Services;social interventions;Specimen;Statistical Methods;symposium;tool;Training;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Update;virology;Vision;web site;Work;working group

PROJECT_TITLE: The Johns Hopkins Center for AIDS Research (JHU CFAR)


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health