ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: RALEIGH

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH The proposed research is relevant to public health because the proposed novel biofeedback combined with neural prosthesis control will improve balance control, postural stability, and balance confidence in individuals with lower limb amputation. This, in turn, improves their community participation and quality of life. The project is relevant to the part of the NIH’s mission such that demonstrating the effectiveness of biofeedback will help individuals with lower limb amputation to improve the capacity to maintain balance, which reduces risk of fall, encourages prosthesis usage, and improves the health of lower limb amputees.

PI_NAMEs: HUANG, HE  (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: Address;Adopted;Affect;Amputation;Amputees;Ankle;ankle joint;ankle prosthesis;Artificial Leg;Biofeedback;Biomechanics;career;Clinical;clinically significant;Cognitive;cognitive process;Community Participation;Cues;Devices;Effectiveness;Environment;Equilibrium;fall risk;haptics;Health;Impairment;improved;Individual;Knowledge;Lead;limb amputation;Limb Prosthesis;Link;Lower Extremity;Mission;Motor;motor control;motor learning;Musculoskeletal Equilibrium;neural prosthesis;neuromuscular;neuroregulation;novel;parent project;Perception;Physical therapy;Posture;powered prosthesis;promote resilience;Prosthesis;prosthesis control;Public Health;Quality of life;Rehabilitation therapy;Research;Resources;response;restoration;Risk Reduction;sensor;sensory substitution;Technology;Time;Torque;training opportunity;United States National Institutes of Health;Visual

PROJECT_TITLE: Toward Restoration of Normative Postural Control and Stability using Neural Control of Powered Prosthetic Ankles

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(03)-M]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: NARRATIVE Dopaminergic neurons are comprised of diverse subsets, and declines in these critical cells contribute to many mental illnesses and neurological disorders. However, the mechanisms responsible for generating and maintaining dopamine neuron diversity are not well mapped. In this project, we examine how a specific kinase pathway programs the numbers, diversity, and connectivity of dopamine neurons with the long-term goal of preserving these cells to improve outcomes in dopamine-regulated mental illnesses and disease.

PI_NAMEs: ARENKIEL, BENJAMIN R;SAMUEL, MELANIE A (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Biochemical;Brain;Brain region;cell type;Cells;Data;Disease;Dopamine;Dopaminergic Cell;dopaminergic neuron;Endowment;Eye;Genetic;Goals;improved outcome;Interneurons;Location;Maps;Mental disorders;Midbrain structure;Molecular;Nervous System Disorder;neural;neurogenetics;Neuromodulator;Neurons;novel therapeutics;Pathway interactions;Phosphotransferases;Play;preservation;Production;programs;Property;Protein-Serine-Threonine Kinases;Retina;Role;Signal Transduction;Specific qualifier value;STK11 gene;Testing;Viral

PROJECT_TITLE: Molecular specification of dopaminergic neuron diversity


PHR: NARRATIVE Several sight threatening diseases involve excessive cell and synapse removal by an important immune cell type called microglia. The goal of this work is to understand the molecular mechanisms that connect microglia function to their intracellular states. Results from this study will inform the longer- term goal of preventing vision loss by modulating microglia-dependent outcomes in eye diseases.

PI_NAMEs: SAMUEL, MELANIE A (contact)

PROJECT_TERMS: Astrocytes;Blindness;CD47 gene;cell type;Cells;Cessation of life;Cues;Data;Development;Disease;Eating;Event;Excision;experimental study;Eye diseases;Goals;Immune;Ligands;Link;Microglia;Molecular;Neurons;neurotransmission;novel therapeutics;Outcome;Phagocytes;Phagocytosis;Physiological;Play;prevent;programs;receptor;Retina;Role;SHPS-1 protein;Signal Transduction;Specific qualifier value;Synapses;Testing;Vision;Work

PROJECT_TITLE: Microglial plasticity mechanisms in the developing retina


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cancer;Clinical Research;Contraception/Reproduction;Fibroid Tumors (Uterine);Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: SAN ANTONIO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE Uterine fibroids (UFs) are the most important benign neoplastic threat to women’s health worldwide, but disproportionately affect women of color, particularly African American (AA) women, who have a threefold higher incidence and relative risk of UFs than European American (EA) women. The underlying cause for this risk disparity is not fully understood, and it is unclear if and how the processes that drive UF formation and determine relative risk are genetically or biochemically linked. This Diversity Supplement to parent grant R01HD087417 is impactful as its suggests a mechanistic basis to couple UF etiology and disease risk through a functional interplay between Vitamin D3 and DNA damage in UFs, and further offers proof-of-concept for clinical treatment of UFs with Vitamin D3 and its FDA-approved nonhormonal analog Doxercalciferol. The studies proposed herein thus address and mechanistically connect three overarching issues in the field: the molecular pathogenesis of UFs, the racial disparity in UF risk, and the development of novel tolerable fertility-saving and cost-effective oral therapies for UFs.

PI_NAMEs: BOYER, THOMAS G (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Accounting;Address;Affinity;African American Women;Agonist;American;analog;Area;Benign;Binding;Biochemical;Biological;Biological Assay;cell growth;Cell Reprogramming;cell transformation;Cells;Cholecalciferol;Chromosomal Breaks;Chromosomal Instability;Chromosomal Loss;Chromosomal Rearrangement;Clinical;Clinical Treatment;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cost effective;Coupled;Defect;design;Development;disorder risk;Disparity;Disproportionately impacts women;DNA Damage;Doxercalciferol;driving force;effective therapy;efficacy evaluation;Enhancers;Etiology;European;FDA approved;Fertility;Fibroid Tumor;Functional disorder;Gene Expression;Genes;Genetic;Genetic Transcription;Genetic Transformation;Genome;genome-wide;Genomic Instability;Habitual Abortion;Half-Life;Health Care Costs;Human;human model;Immunoprecipitation;Impairment;In Vitro;Incidence;Induced Mutation;Infertility;inhibitor;insight;Knock-out;Lesion;Link;Maintenance;Mass Spectrum Analysis;Mediating;Mediator;Menorrhagia;Mitotic;Molecular;Molecular Conformation;Morbidity - disease rate;mouse model;mutant;Mutation;Myometrial;National Institute of Child Health and Human Development;neoplastic;Neoplastic Cell Transformation;novel;novel therapeutics;Oral;Output;parent grant;parent project;Pathogenesis;Pathogenicity;Pelvic Pain;Phosphotransferases;pre-clinical;Pre-Clinical Model;Premature Labor;Process;programs;promoter;Race;racial disparity;receptor;Recurrence;Relative Risks;replication stress;Research Priority;Resolvase;Risk;Risk Factors;RNA Polymerase II;Role;Route;Safety;segregation;Serum;Somatic Mutation;stem cell fate;stem cell self renewal;stem cells;Structural Biochemistry;structural biology;Testing;Therapeutic;Therapeutic Intervention;Toxic effect;transcriptome sequencing;Treatment Efficacy;tumor;Tumor Burden;tumor growth;tumor initiation;tumor progression;Uterine Fibroids;validation studies;Vitamin D3 Receptor;Vitamin Deficiency;Woman;women of color;Women's Health;women's treatment

PROJECT_TITLE: Molecular basis of MED12 in the pathogenesis of uterine fibroids

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(02)-M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Maternal Health;Orphan Drug;Patient Safety;Pediatric;Prevention;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: PORT-AU-PRINCE

ORG_COUNTRY: HAITI

ORG_FIPS: HA

ORG_NAME: GHESKIO CENTER

PHR: Project Narrative: GHESKIO is a Haitian organization dedicated to research, service, and training in HIV/AIDS with a 37 year track record of NIH-funded clinical research. The GHESKIO Clinical Trials Unit has two clinical research sites in Port au Prince and will conduct research in two NIAID networks: The adult HIV/AIDS therapeutic clinical trials group and the maternal-adolescent-pediatric HIV/AIDS trials group. The goal is to improve the treatment of HIV, tuberculosis, and HIV complications across the lifespan in pregnant women, adolescents, children, and adults of all ages in Haiti and around the world.

PI_NAMEs: PAPE, JEAN WILLIAM (contact)

PROGRAM_OFFICER_NAME: SOUTHARD, COURTNEY MEAGAN

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescent;Adult;Age;Anti-Retroviral Agents;Antibody Therapy;antiretroviral therapy;bactericide;Cardiovascular Diseases;Cardiovascular system;Caring;Child;Childhood;Chronic;Chronic Disease;Clinic;Clinical Research;clinical research site;Clinical Trials Cooperative Group;Clinical Trials Unit;co-infection;cohort;Communication;Communities;community intervention;data management;Dedications;Development;Dietary Intervention;Disease remission;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;Early treatment;effectiveness trial;Enrollment;Evaluation;experience;Family;Female;Funding;Goals;Growth;Haiti;Haitian;HIV;HIV-infected adolescents;HIV/AIDS;HIV/TB;Hospitals;hypertension control;Immunity;improved;Infant;Inpatients;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;isoniazid;Isoniazid resistance;Laboratories;Laboratory Research;Lead;life span;male;Maternal-Child Health Centers;Multidrug-Resistant Tuberculosis;National Institute of Allergy and Infectious Disease;neonatal infection;Neurologic;Newborn Infant;novel;Participant;patient population;Patients;pediatric human immunodeficiency virus;pediatrician;Pharmaceutical Preparations;Pharmacy facility;Phase;Population;Pregnant Women;Prevalence;prevent;programs;Prophylactic treatment;Prostitution;recruit;Regimen;Research;Research Infrastructure;Research Personnel;Research Priority;rifapentine;Safety;safety study;Services;Site;Slum;Therapeutic;Therapeutic Clinical Trial;Therapeutic Trials;Training;Training Programs;treatment optimization;treatment trial;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Tuberculosis Vaccines;United States National Institutes of Health;Viral;Vulnerable Populations

PROJECT_TITLE: GHESKIO Clinical Trials Unit


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Dementia;Hydrocephalus;Neurosciences;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Parent Grant Narrative How the brain determines cerebral ventricular volume, and how that in turn affects brain function or the development of normal pressure hydrocephalus, are poorly understood. This proposal will investigate our discovery of an ependymal chemosensory-mechanotransduction system that uses motile cilia to convert chemical signals into changes in flow which govern ependymal cell junction assembly, ventricular wall stiffness and ependymal permeability. By controlling ventricular compliance and the exchange of CSF between the ventricular and interstitial spaces, this system regulates ventricular volume, the relative distribution and composition of fluid in the ventricular and interstitial compartments, and neuronal activity in brain regions that subserve memory and motor functions.

PI_NAMEs: JOHNSON, MARK D (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Acute;Adult;Affect;Agonist;antagonist;awake;beta catenin;Brain;brain abnormalities;Brain region;Calpain;Cells;cerebral atrophy;Cerebrospinal Fluid;cerebrospinal fluid flow;Cerebrum;Characteristics;Chemicals;Cilia;cilium motility;Dementia;dentate gyrus;Development;diagnostic biomarker;DNA Sequence;Drainage procedure;Ependymal Cell;epithelial Na+ channel;Frequencies;Functional disorder;Gait;Gene Expression;Genes;Harvest;Hippocampus;Hydrocephalus;improved;Incontinence;Infection;Intercellular Fluid;Intercellular Junctions;interstitial;Intracranial Hemorrhages;Intracranial Hypertension;Intracranial Pressure;Ligands;Liquid substance;Measures;mechanotransduction;Memory;Motility;Motor;Motor Apraxias;Mus;Mutant Strains Mice;Mutation;Neurologic Deficit;Neurons;Normal Pressure Hydrocephalus;Obstruction;overexpression;p38 Mitogen Activated Protein Kinase;parent grant;Parietal Lobe;Patients;Permeability;Photometry;PI3K/AKT;Piezo 1 ion channel;planar cell polarity;pressure;Process;Production;Proteins;Proteomics;receptor;Receptor Activation;Research Personnel;response;Role;Sensory;sensory system;Serum Proteins;Shunt Device;Signal Pathway;Signal Transduction;Signaling Molecule;Sleep;social;Structure of choroid plexus;subventricular zone;System;transcriptome sequencing;Ventricular

PROJECT_TITLE: A Chemosensory-Mechanotransduction System Regulating Ventricular Size and Brain Function


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: Project Narrative Microsatellite repeat expansions are a growing family of 50+ neurological, neuromuscular, and neurodegenerative diseases that includes the most common cause of adult-onset muscular dystrophy (myotonic dystrophy, DM) and large group of rare neurodegenerative diseases (spinocerebellar ataxias, SCAs). This project, which supports the research and career training of Caroline Pritchard, will focus on bioinformatic approaches to characterize the transcriptomic interface between these repeat expansion disorders. Characterizing shared alternative splicing disease mechanisms in multiple repeat expansion diseases and the synergy in splicing dysregulation at the transcript level will enhance our understanding of the disease biology of SCAs and open new potential avenues for therapeutic development across the entire family of repeat expansion diseases.

PI_NAMEs: BERGLUND, ANDREW  (contact);SHIN, DAMIAN SEUNG-HO;SHORROCK, HANNAH

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Adult;Affect;Alternative Splicing;Bioinformatics;Biology;Brain;CAG repeat;career;Complement;Data;Development;Disease;Family;Microsatellite Repeats;Muscular Dystrophies;Mutation;Myotonic Dystrophy;Myotonic dystrophy type 1;Nervous System Disorder;Neurodegenerative Disorders;Neuromuscular Diseases;novel;parent grant;Pathogenesis;Pathogenicity;polyglutamine;Proteins;Research Support;RNA;RNA Splicing;RNA-Binding Proteins;Role;small molecule;small molecule therapeutics;Spinocerebellar Ataxias;synergism;Technology;Therapeutic;therapeutic development;Training;Transcript;transcriptomics;Translations

PROJECT_TITLE: Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar Ataxias


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Precision Medicine;Prevention;Schizophrenia;Serious Mental Illness;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Though various interventions exist for reducing involvement in the justice system among previously incarcerated people with serious mental illness, no one intervention works for all. This project proposes novel precision medicine methods to understand which justice-involved people with SMI benefit from which interventions. This work will ultimately result in policy recommendations for matching services to the characteristics, needs, and risk factors of those in this population.

PI_NAMEs: MONTOYA, LINA  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: Adult;anti social;Award;Behavior Therapy;Behavioral;Characteristics;Clinical;Cognitive;Cognitive Therapy;court;criminal behavior;Criminal Justice;Data;Dedications;demographics;Development;experience;Foundations;Funding;Goals;Grant;Heterogeneity;Imprisonment;improved outcome;Individual;individualized medicine;Intervention;intervention effect;Justice;Knowledge;Learning;Machine Learning;marginalized community;Mediating;Mental disorders;Mentorship;Methods;National Institute of Mental Health;North Carolina;novel;Outcome;Participant;Pathway interactions;personalized intervention;Persons;Phase;Policies;policy recommendation;Population;Population Heterogeneity;Populations at Risk;Positioning Attribute;precision medicine;prevent;Prevention;Prisons;Probability;psychiatric symptom;Public Health;Randomized, Controlled Trials;recidivism;Recommendation;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Support;Risk Factors;Safety;scale up;Services;severe mental illness;skill acquisition;skills;Statistical Methods;statistics;substance use;Symptoms;System;Talents;Techniques;theories;Time;Training;trait;Translating;treatment as usual;treatment response;treatment strategy;underserved community;Vulnerable Populations;Work

PROJECT_TITLE: What works, for whom? Applying novel precision medicine methods to people with mental illness in the justice system.

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: DA

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Natural Products;Substance Misuse

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: Project Narrative The overarching goal of this proposal is to conduct a placebo-controlled randomized trial comparing the effects of hemp-derived CBD with and without THC, relative to placebo, on reducing cannabis use and CUD symptoms in adult treatment seeking cannabis concentrate users with CUD. This question has enormous public health importance because the field lacks an effective CUD medication, particularly for high potency concentrate users. In addition, hemp-derived CBD products with and without low levels of THC are already widely available to consumers; thus, a positive finding would have an immediate public health impact.

PI_NAMEs: BIDWELL, L. CINNAMON (contact);HUTCHISON, KENT E.

PROGRAM_OFFICER_NAME: WANG, JIA BEI

PROJECT_TERMS: Adult;Affective;affective disturbance;Anxiety;Blood;Cannabidiol;Cannabinoids;Cannabis;cannabis seeking;CNR1 gene;CNR2 gene;Creatinine;Data;Double-Blind Method;drug reward;DSM-V;effective therapy;Flowers;Goals;Hemp;high risk;high risk population;Intervention;marijuana legalization;marijuana use;marijuana use disorder;medication compliance;Monitor;Participant;Patient Self-Report;Pharmaceutical Preparations;physical symptom;Physiological;Placebo Control;placebo controlled trial;Placebos;primary outcome;Protocols documentation;psychologic;Public Health;Randomized;randomized placebo controlled trial;Recreation;recruit;Standardization;Symptoms;Testing;Tetrahydrocannabinol;THC concentration;THC exposure;trial comparing;United States;Urine;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Hemp-derived Cannabidiol for the treatment of cannabis use disorder in concentrate users: A double-blind placebo-controlled randomized trial

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative MyGoals for Healthy Aging is a randomized controlled trial testing if a novel anti-poverty program slows biological aging in highly disadvantaged public housing recipients, including by inducing changes in risk factors for Alzheimer's disease/Alzheimer's disease-related dementias.

PI_NAMEs: BELSKY, DANIEL WALKER;MUENNIG, PETER A (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Acceleration;Age;age acceleration;age related chronic disease;Aging;aging process;aging related;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Automobile Driving;Behavioral;biobank;Biological;biological age;Biological Aging;Biological Assay;Blood;Blood Glucose;blood pressure regulation;Blood specimen;Body System;Brain;C-reactive protein;Caring;Cause of Death;Central Nervous System;Cessation of life;Chronic Disease;Cognition;Cognitive;Cognitive Science;cohort;Collaborations;Collection;Consultations;Control Groups;Crime;Data;Data Collection;Data Linkages;Data Set;dementia risk;design;Development;Diabetes Mellitus;Diet;diet and exercise;Disadvantaged;disparity elimination;disparity reduction;DNA Methylation;economic outcome;Economics;electronic data;Emotional;Employment;epigenetic clock;Executive Dysfunction;executive function;Exercise;Family;field study;follow-up;frailty;Funding;Future;Genes;Glycosylated hemoglobin A;Goals;Health;Health behavior;health disparity;Health Food;Health Insurance;health related quality of life;healthy aging;Height;Homeostasis;Housing;Human;Human Resources;improved;Incentives;Income;Individual;innovation;interdisciplinary approach;Intervention;intervention effect;Investigation;Laboratories;life span;Link;Loneliness;loss of function;Maintenance;Measures;Medical;Memory;Mental Depression;Mental Health;Methodology;Methods;methylation pattern;minority investigator;Moods;mortality;Motivation;National Institute on Aging;neural;Neurons;novel;nutrition;Obesity;Outcome;Outcome Assessment;Outcome Measure;Participant;Pathway interactions;patient engagement;Personal Satisfaction;Persons;Phase;physical conditioning;Population;Poverty;Premature aging syndrome;prevent;Process;programs;Psyche structure;Psychological Stress;Psychologist;Public Housing;Randomized;randomized trial;Randomized, Controlled Trials;rate of aging;Records;Research;research and development;Resources;Risk;Services;Sleep;social;Social Functioning;social health determinants;Social outcome;Social Policies;Stress;success;Surveys;System;Testing;Time;treatment group;Unemployment;United States Dept. of Health and Human Services;Weight;welfare;whole genome;Work

PROJECT_TITLE: The MyGoals for Healthy Aging Multi-Center Randomized Controlled Trial

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LOUISVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Electronic cigarettes (e-cigs) aerosolize a mixture of chemical solvents, flavor additives and nicotine, and inhalation of the resultant aerosol by e-cigarette users has unknown effects on the heart. In this project, we will examine how specific flavoring chemicals that are inhaled during e-cigarette use impact the function of mouse and human heart cells and tissues. Ultimately, this study will advance knowledge of the toxicity of e-cigarettes, which will direct new regulation of e-liquid constituents based on their potential for adverse effects on the heart.

PI_NAMEs: CARLL, ALEX PERROW (contact);NYSTORIAK, MATTHEW A

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Agents;Adult;Adverse effects;aerosolized;Aerosols;Affect;air filter;Anatomy;Arrhythmia;Attention;Blood Vessels;Breeding;Cardiac;Cardiac Electrophysiologic Techniques;Cardiac Myocytes;Cardiotoxicity;cardiovascular effects;cardiovascular risk factor;Cardiovascular system;Cause of Death;Chemicals;Child;Chronic;combustible cigarette;Compensation;Data;density;Devices;e-cigarette aerosols;Echocardiography;Electrocardiogram;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Event;Exposure to;Fellowship;Female;Fibrosis;Flavoring;Frequencies;Health;Heart;heart cell;Heart Rate;heart rate variability;Heating;hemodynamics;Human;Hypertrophy;Impairment;In Vitro;in vivo;Incidence;Individual;Inflammation;Ingestion;Inhalation;Isolectin;Knowledge;Long-Term Effects;manufacture;Marketing;Maternal Mortality;Mechanics;Morbidity - disease rate;mortality;Mus;Necrosis;Nicotine;nicotine exposure;Outcome;parent grant;Performance;Periodicity;Physiology;Policies;Population;Positioning Attribute;post pregnancy;Postdoctoral Fellow;Predisposition;Pregnancy;pregnant;Pregnant Women;pressure;Regulation;research faculty;Research Priority;Risk;Risk Factors;sex;Signal Transduction;skills;Smoker;Solvents;Stains;Stress;Structure;sudden cardiac death;Telemetry;Testing;Time;Tissues;tobacco advertising;Toxic effect;Toxicology;Ventricular;Ventricular Arrhythmia;Work

PROJECT_TITLE: Systematic identification of cardiotoxic e-cigarette flavorants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(56)-R]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This research aims to accelerate the implementation of evidence-based interventions to reduce health disparities and promote health for Latinos in the rural United States. In this study, we will adapt, implement, and evaluate the effectiveness of El Valor, a Latino-focused retail food store (tienda) evidence-based intervention to increase the consumption of fruits and vegetables delivered by community health workers for Latinos living in rural communities. We address diet health disparities through our participatory research process, an implementation equity research focus, and innovative application of community health workers delivering the intervention in retail and commercial settings.

PI_NAMEs: BAQUERO, BARBARA I (contact)

PROGRAM_OFFICER_NAME: AKUBU-ODERO, MAUREEN KALAMBU

PROJECT_TERMS: Acceleration;Address;Affect;Agricultural Workers;Behavior;Behavioral;bilingualism;California;cancer type;Cessation of life;Chronic Disease;Communities;community based participatory research;Community Health Aides;Community Networks;community research;Commuting;Consumption;County;Data;design;Desire for food;Diabetes Mellitus;Diet;disease disparity;Disparity;Effectiveness;effectiveness evaluation;Employee;Environment;Environmental Risk Factor;Equity;Ethnic Origin;Ethnic Population;Evidence based intervention;experience;follow-up;Food;Food Access;food environment;fruits and vegetables;Funding;good diet;Health;health disparity;health equity;Health Food;health inequalities;Health Promotion;Hybrids;Immigrant worker;implementation evaluation;Inequity;innovation;Intervention;intervention effect;Knowledge;Latina;Latino;Latino Population;Latinx;Malignant Neoplasms;Measures;member;Methods;Modeling;Morbidity - disease rate;multidisciplinary;North Carolina;Obesity;Outcome;Process;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Reporting;Research;Research Design;Risk;Rural;rural area;Rural Community;rural counties;Rural Health;Services;social;Social Change;social factors;social health determinants;Social Work;structural determinants;suburb;Testing;theories;therapy development;Training;Translating;Transportation;Trust;Unhealthy Diet;United States;Wages;Washington

PROJECT_TITLE: Nuestro Valor: Increasing healthier food access for rural Latino communities through a food retail intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZNR1 REV-M (44)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: The vascular contributions to cognitive impairment and dementia are well recognized mediators of Alzheimer's disease and related disorders, and endothelial cells are essential players in the vascular pathology due to their role of gatekeepers of the blood-brain barrier (BBB). Micro RNAs are short non-coding RNAs that regulate cell survival and function, but their role as contributors to endothelial cell stress and death mechanisms as well as BBB permeability in AD and cerebral vascular amyloidosis is largely unknown. Here, through the use of human endothelial cells in culture and vessels purified from mouse and human brains with vascular amyloid deposits, we plan to test the hypothesis that the miR-212 downregulation induced by Amyloid β contributes to BBB failure and neurovascular dysfunction in AD and related dementias.

PI_NAMEs: FOSSATI, SILVIA  (contact);HÉBERT, SÉBASTIEN

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;abeta deposition;abeta oligomer;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Amyloidosis;Apoptosis;Binding;Blood;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier disruption;blood-brain barrier permeabilization;Brain;Cell Death;Cell Physiology;Cell Survival;Cells;Cellular Stress;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Complex;Data;Deposition;Diagnosis;Disease;Disease Progression;Down-Regulation;Endothelial Cells;Exhibits;exosome;Failure;Functional disorder;Funding;Gatekeeping;Genes;Goals;Grant;Human;Inflammatory;loss of function;Measures;Mediator;MicroRNAs;Mus;Neurofibrillary Tangles;neuroinflammation;neurovascular;neurovascular unit;parent grant;Pathology;Permeability;Phenotype;Play;Post-Transcriptional Regulation;Regulation;Role;Senile Plaques;System;Testing;Untranslated RNA;vascular cognitive impairment and dementia

PROJECT_TITLE: Vascular MicroRNA-212 in CAA and Alzheimer's disease


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Prevention;Stroke

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative: Down syndrome (DS) is one of the most common genetic disorders with a prevalence of 1 per 700 liveborn infants in the United States and is associated with an increased risk of developing cerebrovascular disorders (CeVD), which commonly present with stroke as the first evidence of disease. The proposed research will result in the creation of a validated, non-invasive, low-cost, biometric screening tool for young persons with DS in order to address the pressing need of reliable screening of CeVD in at-risk individuals. This proposal presents a five-year research career development program with training that will position me with a unique set of interdisciplinary skills to enable transition to independence as a physician-scientist to study the prediction and prevention of CeVD in persons with DS.

PI_NAMEs: SANTORO, JONATHAN DOUGLAS (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Acceleration;Accounting;Active Learning;Address;Age;aged;Architecture;Area;Bioinformatics;Biological Markers;biomedical informatics;Biometry;Blood Pressure;blood pressure elevation;blood pressure reduction;Blood Vessels;Brain;career;career development;Caring;CCL2 gene;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Child;Childhood;Chronic;chronic inflammatory disease;Clinical Trials;Clinical Trials Design;cohort;Communication;comparison control;Competence;cost;Data;Data Analyses;Deposition;design;Development;Development Plans;Diagnosis;Disease;Disease Pathway;Down's Syndrome;Early Diagnosis;Early identification;Early Intervention;early screening;Edema;Educational workshop;Ensure;Epidemiology;Etiology;experience;feasibility research;Functional disorder;Funding;Genetic Diseases;Gliosis;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Head and neck structure;Health;Health Sciences;Healthcare;Height;Hemosiderin;Home;Hypertension;Hypotension;Image;Immune;improved;Incidence;Individual;Infant;Inflammation;Inflammatory;Institution;Interferon Type II;interleukin-22;Interleukin-6;Investigation;K-Series Research Career Programs;Knowledge;Learning;Link;Location;Los Angeles;Magnetic Resonance Imaging;Measurement;Measures;Mentors;Mentorship;Metabolic dysfunction;Modality;Morbidity - disease rate;mortality;Moyamoya Disease;Neck;Neurocognitive;neurocognitive test;neurodevelopment;neuroimaging;Neurologic;Neurologic Symptoms;Patients;Persons;PGF gene;Physicians;population based;Positioning Attribute;predictive marker;Prevalence;prevent;Prevention;Program Development;prospective;Prospective Studies;Publishing;Regression Analysis;Reproducibility;Research;Research Personnel;response;Retrospective Studies;Risk;Risk Assessment;Role;Scientist;screening;Screening procedure;Secondary to;sex;skills;Standardization;Stenosis;Stroke;systemic inflammatory response;Techniques;Therapeutic Intervention;Time;TNF gene;tool;Training;Transcranial Doppler Ultrasonography;Ultrasonography;United States;United States National Institutes of Health;Vascular Cell Adhesion Molecule-1;Vascular Diseases;Vascular Endothelial Growth Factors;vascular inflammation;Weight;Work

PROJECT_TITLE: Non-invasive biometric screening for cerebrovascular disorders in persons with Down syndrome.

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The reprogramming of differentiated cells to induced pluripotent stem cells represents a remarkable reconfiguration of gene regulatory programs and provides the unprecedented ability to generate any type of human cell in unlimited amounts for therapeutic purposes and drug screening. The goal of this project is to identify the general principle regarding transcription factors remodeling cellular networks that define human cell identities. The results of this project will further reveal how human genetic variation affects the establishment and maintenance of the induced stem cell state.

PI_NAMEs: LUO, CHONGYUAN  (contact);PLATH, KATHRIN ;ZAITLEN, NOAH A

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Affect;Alleles;Architecture;ATAC-seq;Binding;Biological Assay;c-myc Genes;causal variant;Cell Differentiation process;Cell Line;Cell Nucleus;cell type;Cells;Cellular Morphology;Characteristics;ChIP-seq;Chromatin;Classification;Clustered Regularly Interspaced Short Palindromic Repeats;Computer Models;CRISPR interference;Cytosine;Data;Data Set;Development;disease model;DNA Methylation;Drug Screening;embryonic stem cell;Enhancers;epigenetic regulation;epigenome;epigenomics;Event;experimental study;Fibroblasts;Gene Expression;Gene Expression Regulation;gene interaction;gene regulatory network;Genes;Genetic;Genetic Engineering;genetic variant;Genetic Variation;genome-wide;genomic data;Genomics;Goals;histone modification;Human;human embryonic stem cell;Human Genetics;human induced pluripotent stem cells;Individual;induced pluripotent stem cell;innovation;insight;Joints;Knowledge;Maintenance;Mammalian Cell;Measurement;Mediating;Methods;Methylation;Modeling;Molecular;Molecular Conformation;Mouse Strains;Multiomic Data;multiple omics;Nature;Noise;novel;overexpression;personalized medicine;Phenotype;pluripotency;Population;predictive modeling;Process;programs;Quantitative Trait Loci;Regenerative Medicine;Regulation;Regulatory Element;repaired;Repression;Resolution;risk variant;RNA;RNA methylation;Role;Series;single cell ATAC-seq;single-cell RNA sequencing;Site;Somatic Cell;Specificity;Statistical Methods;stem cells;System;Testing;Therapeutic;Time;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Leveraging genetic variation to dissect gene regulatory networks of reprogramming to pluripotency


ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative We will determine the role of immune mechanisms in driving HIV persistence, elimination, or expansion of HIV infected clones, and determine whether immune selective pressures shape clone size and composition in young adults in the U.S. living with perinatal HIV-1. In this protocol, we will determine whether the reservoir properties are similar in individuals who acquire HIV with immature immune systems. By identifying and overcoming obstacles to engagement of underrepresented populations, this project advances the overall goal of improving equity and justice in participant selection for clinical studies, which has important impact on relevant strategies for HIV cure research in this population.

PI_NAMEs: CHAHROUDI, ANN M;PERSAUD, DEBORAH  (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Achievement;Adolescent;Adult;Automobile Driving;Binding;Childhood;Clinical;clinical center;Clinical Data;Clinical Research;Clonal Expansion;Collaborations;collaboratory;Dedications;Equity;Evaluation;Goals;HIV;HIV Infections;HIV-1;Immune;Immune system;Immunologics;improved;Individual;innovation;International;Justice;Laboratories;Long-Term Effects;Longitudinal Studies;novel;Participant;pediatric human immunodeficiency virus;perinatal HIV;Population;pressure;programs;Property;Protocols documentation;recruit;Registries;Research;research study;Resources;Role;Sampling;Seminal;Shapes;Source;Techniques;tool;Underrepresented Populations;United States National Institutes of Health;Viremia;Virus;young adult

PROJECT_TITLE: Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney Collaboratory


NIH_SPENDING_CATS: Genetics;Human Genome

PHR: PROJECT NARRATIVE UNC was asked by NHGRI leadership to request supplemental funds to cover the planning and execution of the Genomic Medicine XV Meeting, sponsored by the NHGRI and hosted in-person in the Washington, DC area tentatively scheduled over two days in December, 2024.

PI_NAMEs: BERG, JONATHAN S (contact)

PROGRAM_OFFICER_NAME: VOLPI, SIMONA

PROJECT_TERMS: Address;Administrative Supplement;American;Area;Clinical;Communicable Diseases;Funding;Genes;genome resource;Genomic medicine;Genomics;Grant;Hybrids;Leadership;Medical Genetics;medical schools;meetings;member;National Human Genome Research Institute;Persons;Research;Schedule;Science;Variant;virtual;Washington;working group

PROJECT_TITLE: Administrative Supplement: The Clinical Genome Resource - Advancing genomic medicine through biocuration and expert assessment of genes and variants at scale


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

PHR: Hepatocellular carcinoma (HCC) is a very common and lethal cancer in Africa, and as patients with HIV live longer, the burden of HCC may increase. The proposed Consortium will conduct clinical research projects in Uganda and Senegal to investigate if and how treatment of HCC-causing infections may prevent HCC. In parallel, Consortium resources are applied towards developing human and clinical research capacity in both countries to address the growing problem of HIV and HCC.

PI_NAMEs: KIRK, GREGORY D (contact);OCAMA, PONSIANO

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Address;Advocate;Africa;Africa South of the Sahara;African;Age;career development;Chronic;chronic infection;Clinical;Clinical Research;Country;Data;design;Development;Goals;Hepatitis B Infection;Hepatitis B Therapy;Hepatitis B Virus;Hepatitis C virus;HIV;Human;Immune response;Individual;Infection;interest;Interruption;Investigation;Liver;Malignant Neoplasms;Medical;Mentors;novel marker;Patients;Persons;Pilot Projects;Population Research;prevent;Primary carcinoma of the liver cells;Prospective cohort;Research;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Schistosoma mansonii infection;Senegal;Translational Research;Uganda;Universities

PROJECT_TITLE: HIV and HCC in Africa: The H2A Consortium


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infectious Diseases;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE (of the Parent Award) Spontaneous pregnancy loss is a devastating and serious public health problem affecting 1 in 4 women worldwide. Uterine infection is associated with implantation failure but how infection affects endometrial function remains unknown. The proposed research will determine the mechanisms by which double-stranded RNA that is present in all viruses impact endometrial decidualization and communication with placental trophoblasts, contributing to our current understanding of the pathophysiology of early pregnancy loss in women who have been exposed to infection.

PI_NAMEs: TONG, MANCY  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acceleration;Affect;Angiogenic Factor;Bacterial Infections;Binding;Biology;Cell Communication;Cell Differentiation process;Cell Physiology;cell type;Chromosome abnormality;Coculture Techniques;Communication;cytokine;Data;Decidual Cell;Decidual Cell Reactions;Double-Stranded RNA;early pregnancy loss;Endometrial;Endometrial Stromal Cell;Endometrium;Enzyme-Linked Immunosorbent Assay;Escherichia coli;Exposure to;extracellular vesicles;failure Implantation;fetal;Fetal Growth Retardation;Functional disorder;Gestational Age;healthy pregnancy;Human Herpesvirus 2;Impairment;implantation;improved;in vivo;Infection;Infection prevention;Inflammatory;inhibitor;Innate Immune Response;insight;intercellular communication;interest;Invaded;Knowledge;Link;Lipids;MAP Kinase Gene;Maternal-Fetal Exchange;Mediating;Membrane;Microbe;migration;Modeling;Monitor;Mothers;mouse model;Mus;natural Blastocyst Implantation;novel;Nucleic Acids;obstetrical complication;Outcome;p38 Mitogen Activated Protein Kinase;parent project;Partner in relationship;PGF gene;Phase;Placenta;placental trophoblasts;Placentation;Play;Poly I-C;Pre-Eclampsia;Pregnancy;Pregnancy loss;Premature Birth;Process;Production;Progesterone Receptors;Proteins;Public Health;pup;Receptor Signaling;Reproductive Immunology;Research;Rest;Risk;senescence;senescent cell;Series;Signal Transduction;Spontaneous abortion;success;Testing;Therapeutic;three-dimensional modeling;TLR3 gene;trophoblast;Uterus;vesicular release;Viral;Virus;Virus Diseases;Weight;Woman;Work

PROJECT_TITLE: Mechanisms of Endometrial Innate Immune Responses to Infection and Impact on Placental Interactions


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The proposed research is relevant to public health because it will lead to development of biomarkers that reflect granular neurobiological principles underlying ASD and related neurodevelopmental conditions. Among these individuals, understanding and addressing challenges related to atypical sensory processing is repeatedly noted as a common goal that would improve quality of life. In the long term, by developing objective brain-based measures of sensory processing (which has historically been a subjective phenomenon), this work has the potential to elevate research for a host of different diseases, alongside a wide variety of neurodevelopmental and sensory conditions.

PI_NAMEs: LEVIN, APRIL R. (contact)

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 4 year old;Address;Anxiety;Attention;autism spectrum disorder;autistic children;behavior prediction;Behavioral;behavioral phenotyping;Biological Markers;biomarker development;biotypes;Brain;brain based;Caregivers;Child;Classification;clinical diagnostics;Complement;Data;Development;diagnostic development;Disease;Electroencephalography;endophenotype;Functional disorder;functional outcomes;Goals;improved;Individual;individuals with autism spectrum disorder;innovation;Measurement;Measures;Methods;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuromechanism;Neurophysiology - biologic function;novel;outcome prediction;personalized medicine;Public Health;Quality of life;Research;response;Sensory;sensory input;Sensory Process;sensory stimulus;social skills;Stratification;Subgroup;Symptoms;Testing;time use;Work

PROJECT_TITLE: Paradoxical Sensory Responses: A Clue Towards Understanding Biotypes in Autism Spectrum Disorder and Other Neurodevelopmental Disorders (R01 Diversity Supplement - Mankaryous)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Los Angeles

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative  The proposed work will uncover intrinsic shape of DNA duplexes and elucidate its roles in CRSIPR Cas9 and Cas12a target discrimination. Information learned will be incorporated into algorithms for enhancing CRISPR targeting specificity, ultimately advancing CRISPR-based technologies for effective genome manipulation in both basic research and therapeutic development.

PI_NAMEs: QIN, PETER Z (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 3-Dimensional;Administrative Supplement;Affect;Algorithms;Award;Base Pairing;Basic Science;Biology;Cells;Chromatography;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Development;Discrimination;Distal;DNA;DNA Sequence;DNA-Binding Proteins;ds-DNA;Engineering;equipment acquisition;experimental study;FASTK Gene;Funding;Gene Targeting;Genes;Genome;genome editing;genome-wide;Guide RNA;improved;instrument;interest;Learning;Liquid substance;Methods;Molecular Conformation;National Institute of General Medical Sciences;next generation;Nucleic Acids;Parents;Peripheral;physical property;Productivity;Proteins;research and development;RNA;Role;Shapes;Site;Specificity;Spin Labels;System;Technology;Therapeutic;therapeutic development;Work

PROJECT_TITLE: Supplement: Acquisition of an NGC Discover 10 Pro Chromatography System


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Caregiving Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: CHICAGO

ORG_NAME: LOYOLA UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed project will identify the culture-specific linguistic experiences that support Latino children's healthy bilingual development. Carrying out the proposed research activities and career development plan, Ms. Carbajal will be better positioned for an independent research career in the health-related sciences.

PI_NAMEs: GAMEZ, PERLA B. (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Agreement;Award;Behavior;bilingualism;career;career development;Caregivers;caregiving;Child;Child Language;Child Support;Code;cohesion;cultural values;Data;Development;Development Plans;dyadic interaction;Emotional;Environment;experience;Exposure to;Family;Fostering;Grant;hands on research;Health;innovation;journal article;Knowledge;Language;Language Development;language outcome;Latino;Latino Population;Lead;Linguistics;meetings;Mentors;Methods;nutrition;Outcome;parent grant;Parents;Pathway interactions;Play;Positioning Attribute;primary caregiver;professor;Publishing;Research;Research Activity;research and development;Science;skill acquisition;Source;Spanish;Speech;Structure;success;symposium;United States National Institutes of Health;Video Recording

PROJECT_TITLE: Spanish-speaking Latinos' Early Language Environments and Dual Language Development


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Comparative Effectiveness Research;Neurosciences;Pediatric

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: The proposed research examines the neurocognitive bases of treatment response to a well-established evidence-based treatment program. We use pre and post treatment neuroimaging and, for the first time, frequent neuroimaging during the course of treatment 1) to gain new insights into how evidence-based treatment modulates brain organization for literacy, language learning, and remediation; and 2) why it fails to do so for some children. The proposed research represents a key step towards the development of comprehensive and mechanistic models of the neural underpinnings of typical and atypical reading development.

PI_NAMEs: PUGH, KENNETH R. (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: adaptive learning;Aftercare;Age;base;Behavior;behavior change;Brain;brain based;Brain imaging;Child;Code;Cognitive;cohort;coping;Dependence;design;Development;Dimensions;disabled;Disabled Children;Educational Technology;Electroencephalography;elementary school;Employment;evidence base;Evidence based treatment;Exhibits;experimental study;Follow-Up Studies;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Funding;Goals;Grant;Image;insight;Instruction;junior high school;Language Development;Learning;literacy;Measures;Modeling;neural;neural model;Neurobiology;Neurocognitive;neuroimaging;novel;Outcome;Phase;Reading;recruit;remediation;Research;Research Project Summaries;response;Sampling;Schools;Technology;Testing;Time;Training;treatment program;treatment response;Variant

PROJECT_TITLE: Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Congenital Structural Anomalies;Down Syndrome;Heart Disease;Intellectual and Developmental Disabilities (IDD);Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: NARRATIVE The fundamental question for the field of Down Syndrome (DS) basic research is how an extra copy of human chromosome 21 (HSA21) translates into the organ-specific defects observed in the DS population. Control of when cells differentiate from progenitor to differentiated cell is important for normal organ formation. We will test the overall hypothesis that altered Hh signaling response and cardiac differentiation timing is a mechanism underlying increased CHD risk in DS.

PI_NAMEs: MOSKOWITZ, IVAN PAUL (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Affect;Anterior;Basic Science;Cardiac;cardiogenesis;Cell Differentiation process;Chromosome 21;Complex;Congenital Abnormality;Defect;Development;Down's Syndrome;Equilibrium;Erinaceidae;Failure;Gene Expression Regulation;Growth;Heart;heart defect;Human Chromosomes;Laboratory Finding;Literature;Molecular;Morphogenesis;Organ;Organogenesis;parent project;Pathology;Patients;Pattern;Population;progenitor;Proliferating;response;Risk;Signal Pathway;Signal Transduction;stem cell differentiation;stem cells;Structure;Testing;Time;Translating;Tretinoin;Work

PROJECT_TITLE: Trisomy 21 and its impact on hedgehog-dependent gene regulation and  differentiation timing


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetic Testing;Genetics;Precision Medicine;Prevention;Wound Healing and Care

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

PHR: Project narrative  In this work, we will develop and validate prognostic biomarkers for prediction of diabetic wound healing. The optimized biomarkers would allow the identification of individuals who are not likely to heal their ulcer when treated with the standard of care, for use in the personalization of treatment and/or the refinement of entry criteria for clinical trials of new treatments.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: JONES, TERESA L Z

PROJECT_TERMS: Area;Base Ratios;Biological Markers;Cells;Chronic;Clinical;clinical effect;Clinical Trials;cohort;collagen scaffold;Complex;cost;Death Rate;Debridement;Detection;Diabetic Foot;Diabetic Foot Ulcer;diabetic patient;diabetic wound healing;Ensure;Foundations;Gene Expression;Gene Expression Profiling;Genes;Genetic Markers;Goals;healing;Human;immune activation;Impaired wound healing;Impairment;In Vitro;indexing;Individual;Inflammation;Inflammatory;limb amputation;Link;Lower Extremity;Measurement;Measures;meetings;Methods;non-healing wounds;patient variability;Patients;personalized medicine;Phase;Phase II Clinical Trials;predicting response;predictive marker;Process;prognostic;Prognostic Marker;prognostic value;Quality Control;Quantitative Reverse Transcriptase PCR;Reproducibility;Research;Resolution;responders and non-responders;response;RNA;ROC Curve;sample collection;Sampling;secondary analysis;Sensitivity and Specificity;Shipping;Specificity;standard of care;Standardization;Techniques;Time;Tissue Banks;Tissue Model;Tissue Sample;Ulcer;United States;Visit;Work;wound;wound care;wound healing

PROJECT_TITLE: Inflammation-related gene biomarkers in human diabetic foot ulcer healing


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: The proposed research will reveal how non-invasive brain stimulation promotes protective immune functions in the context of genetic risk for Alzheimer’s disease. These findings will lay the foundation for new early intervention for Alzheimer’s disease. The proposed project provides an enhanced training opportunity for a promising graduate student from a group underrepresented in science.

PI_NAMEs: SINGER, ANNABELLE CATHERINE (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid beta-Protein;amyloid pathology;Amyloidosis;Animal Model;Animals;Anti-Inflammatory Agents;apolipoprotein E-4;Astrocytes;Behavior;beta amyloid pathology;Biological Assay;Brain;cell type;Cells;cytokine;Data;Dementia;Disease;Early Intervention;Environment;Enzyme-Linked Immunosorbent Assay;experience;Foundations;Frequencies;Funding;Future;Gene Expression Profile;Genes;genetic manipulation;Genetic Risk;genetic risk factor;Genetic Transcription;Goals;graduate student;Health;Hippocampus;Human;human tissue;Immune;immune function;Impairment;improved;Inflammation;Inflammatory;innovation;Knock-in Mouse;Lead;Learning;Light;Memory;Memory impairment;Memory Loss;memory process;Mentorship;Methods;Microglia;mouse model;Mus;Nerve Degeneration;neural;Neuroglia;Neuroimmune;Neurons;neurotransmission;NF-kappa B;noninvasive brain stimulation;novel therapeutic intervention;parent grant;Pathogenesis;Pathology;Persons;pharmacologic;Phenotype;Play;Populations at Risk;Positioning Attribute;pre-clinical;Pre-Clinical Model;pre-clinical therapy;Predisposition;Prefrontal Cortex;Principal Investigator;Process;promote resilience;prophylactic;Proteins;recruit;Research;Research Project Grants;resilience;response;Rewards;RiboTag;Risk;Role;safety and feasibility;Science;Senile Plaques;Sensory;Signal Transduction;small hairpin RNA;sound;Synapses;Testing;Training;training opportunity;transcriptomics;Underrepresented Populations;virtual environment;Wood material;Work

PROJECT_TITLE: Diversity Supplement: Effects of stimulation on resilience in brain immune cells


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Infectious Diseases;Malaria;Neurosciences;Pediatric;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE Identification of the key central nervous system and systemic factors that together contribute to neurodevelopmental impairment in cerebral malaria or severe malarial anemia could lead to interventions that prevent or decrease brain injury and the loss of developmental potential in hundreds of thousands of children in malaria endemic areas of Africa.

PI_NAMEs: JOHN, CHANDY C. (contact);OPOKA, ROBERT

PROJECT_TERMS: 4 year old;Acute Renal Failure with Renal Papillary Necrosis;Affect;Africa;Age;Area;Atrophic;Behavior;Biology;Blood flow;Blood Vessels;Brain;Brain Injuries;brain magnetic resonance imaging;Central Nervous System;Central Nervous System Diseases;Cephalic;cerebral atrophy;Cerebral Malaria;Cerebrovascular Circulation;Child;Childhood;Clinical;Cognition;cohort;Communities;Control Groups;cytokine;Data;design;Development;Disease;Electroencephalography;Electrophysiology (science);Endothelium;Enrollment;Evaluation;Event-Related Potentials;follow-up;Functional disorder;global health;Goals;Immune response;Impairment;Indiana;Inflammatory;inflammatory marker;Intervention;Investments;Kenya;machine learning model;Magnetic Resonance Imaging;Malaria;malarial anemia;Malawi;Mediating;Mediation;Multifocal Lesion;neurodevelopment;Neurodevelopmental Impairment;Neurological observations;neuroregulation;neurotransmission;novel;Obstruction;Pathway interactions;Pattern;Plasma;point of care;point of care testing;prevent;Process;public health relevance;Qualifying;Recovery;Reproducibility;Research;response;Risk;Risk Factors;Statistical Models;System;Testing;Training;Transcranial Doppler Ultrasonography;Traumatic Brain Injury;UCHL1 gene;Uganda;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Severe Malaria And Risk to The Brain (SMART Brain)


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_DEPT: BIOCHEMISTRY

PHR: Contact PD/PI: WEK, RONALD C PROJECT NARRATIVE Metabolic diseases, including diabetes mellitus and obesity, are major public health concerns in the US and worldwide. The objective of this Training Program is to recruit, mentor, and train a talented and diverse cadre of scientists to carry out cutting-edge basic science and translational research focused on improving the health of individuals with or at risk of type 1 and type 2 diabetes, obesity, and their associated complications. This program will leverage the infrastructure, resources, and rich training environment of the Indiana University School of Medicine and the Indiana Diabetes Research Center to nurture the careers of the next generation of diabetes, obesity, and metabolism investigators. Project Narrative Page 7

PI_NAMEs: EVANS-MOLINA, CARMELLA ;WEK, RONALD C (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TITLE: Diabetes and Obesity Training Grant

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Various adverse and protective environments may affect child development. The Healthy Brain and Child Development National Consortium (HBCD-NC) will follow 7,500 mothers and their children from locations across the U.S. from before birth to 10 years of age to better understand which harmful and protective environments exert the greatest impact on child development. This study will help to improve the health and development of children across the nation.

PI_NAMEs: NORTON, ELIZABETH SPENCER;WAKSCHLAG, LAUREN S (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: 10 year old;Address;Affect;Alcohols;Behavioral;Biological;Birth;Brain;Child;Child Development;cohort;Communities;Data Coordinating Center;Data Set;Development;early experience;Electroencephalography;Enrollment;Environment;Environmental Exposure;Environmental Hazards;Ethnic Origin;Exposure to;Genes;Goals;hazard;Health;Helping to End Addiction Long-term;improved;Infant;innovation;insight;Life;Location;Magnetic Resonance Imaging;maltreatment;Marijuana;Maternal Health;Measures;Methods;Mothers;multidimensional data;multimodality;neuroimaging;novel;Opiate Addiction;Opioid;opioid misuse;Outcome;Physiological;Population;postnatal;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Process;Protocols documentation;psychologic;Psychopathology;Public Health;Public Policy;Race;Research;Sampling;Shapes;Site;socioeconomics;Speed;Stress;Structural Racism;substance use;Time Study;Tobacco;tool;Toxicant exposure;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: 9/24- Healthy Brain and Child Development National Consortium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE This study is designed to help improve the care of SGM with AD/ADRD in LTSS by conducting a rigorous study of the policies of LTSS agencies in Minnesota and by training the state’s LTSS workforce in SGM culturally responsive care. The study of policy will inform whether LTSS agencies need regulation or have already adopted SGM appropriate policies. The randomized controlled trial will rigorously test the effects of an in- person versus an online training program on improving SGM culturally responsive care.

PI_NAMEs: ROSSER, B R SIMON  (contact);SHIPPEE, TETYANA P.

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adopted;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;arm;Assisted Living Facilities;Attention;Attitude;Caring;Certification;cisgender;Client;comparative effectiveness study;Control Groups;Data Collection;dementia care;design;Discrimination;E-learning;Educational Curriculum;Educational Intervention;Effectiveness;efficacy evaluation;Environment;evidence base;Evidence based intervention;Family member;follow-up;Fright;Funding;Gender Identity;gender minority health disparity;Health;health care availability;health care service;health disparity;Heterosexuals;Hostility;human old age (65+);Human Resources;Impaired cognition;improved;Individual;Inferior;Instruction;Intake;Intervention;Knowledge;Lesbian Gay Bisexual;Licensing;Long-Term Care;Long-Term Effects;Marketing;Medicare/Medicaid;Methods;Minnesota;Minority;Modeling;Nursing Homes;older adult;online course;online intervention;online version;Outcome;Participant;peer;Persons;Policies;Policy Analysis;Population;Prevalence;Quality of life;Randomized, Controlled Trials;Regulation;Religion;Research;Risk;Rural;Safety;satisfaction;Service provision;Services;Sex Orientation;Sexual and Gender Minorities;skills;Social Work;sound;Statutes and Laws;Testing;Training;Training Programs;Training Support;transgender;United States National Institutes of Health;Violence;Waiting Lists

PROJECT_TITLE: Training the Long-Term Services and Supports Dementia Care Workforce in Provision of Care to Sexual and Gender Minority Residents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(02)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Epilepsy;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LA JOLLA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE This goals of this project are to (1) investigate longitudinal trajectories of cognitive and brain aging in older adults with epilepsy, and (2) identify modifiable risk factors to mitigate or prevent cognitive decline and progression to dementia. This research will be accomplished by combining advanced structural, diffusion, and perfusion imaging with neuropsychological, CSF biomarker and vascular risk factor data to model cognitive and brain changes, as well as moderators of change, over a 5-year period. The information gained from this investigation may help to shift epilepsy care beyond seizure control to include factors to protect and promote brain health in our elderly patients.

PI_NAMEs: MCDONALD, CARRIE R (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Acceleration;Adult;adverse outcome;Age;age acceleration;aging brain;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Apolipoproteins;Benchmarking;Biological Markers;Blood Vessels;Brain;brain health;Caring;Cerebrospinal Fluid;Cognition;Cognitive;Data;Dementia;Diffusion;Disease;Epilepsy;ethnic diversity;Frontal Lobe Epilepsy;Genetic;Geography;Goals;Grant;Health Care Costs;Healthcare Systems;hypoperfusion;Image;Impaired cognition;Incidence;Individual;Investigation;life span;Link;mild cognitive impairment;Modeling;modifiable risk;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurodegenerative Disorders;neuroimaging;Neuropsychology;normal aging;older adult;older patient;Partial Epilepsies;Pathology;Patient Care;Patients;perfusion imaging;Population;Prevalence;prevent;progression risk;Public Health;Quality of life;racial diversity;regional atrophy;Research;Risk;Risk Factors;Seizures;Site;tau Proteins;Temporal Lobe Epilepsy;Therapeutic;vascular risk factor;white matter injury

PROJECT_TITLE: BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigation of vascular, genetic, and biomarker risk profiles in elderly patients with epilepsy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE This administrative supplement project examines whether criminal legal system involvement impedes the reach of harm reduction services and exacerbates overdose mortality. This evaluation could help clarify for policymakers and service providers what practices or barriers need to be adapted to improve the health of people who use drugs. These findings are critical for public health and public safety agencies who continue to struggle with solutions that reduce overdose mortality in the United States.

PI_NAMEs: KRAL, ALEXANDER H (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Address;Administrative Supplement;Affect;Anticonvulsants;Collaborations;Communities;community-level factor;contagion;Crime;Data;data harmonization;drug market;Drug usage;Drug user;Effectiveness;effectiveness evaluation;Epidemiologist;Equity;Evaluation;Event;Fright;Funding;Future;Harm Reduction;Health;Helping to End Addiction Long-term;Illicit Drugs;Imprisonment;improved;innovation;International;Intervention;Investigation;Legal system;Manuscripts;Measures;Medical Examiners;Metric System;Modeling;mortality;Municipalities;National Institute of Drug Abuse;Opiate Addiction;opiate tolerance;Opioid;opioid misuse;Outcome;Overdose;overdose death;Overdose reduction;overdose risk;parent grant;parent project;Parents;Peer Review;Persons;Pharmaceutical Preparations;Police;Policy Maker;Predisposition;protective factors;Public Health;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Research Personnel;Safety;Sampling;San Francisco;service providers;Services;Site;Smoke;Speed;success;Supervision;Surveys;Testing;Time;Travel;United States;United States National Institutes of Health;Writing

PROJECT_TITLE: Assessing the Reach, Effectiveness, and Implementation of Multiple Harm Reduction Interventions.


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: COLLEGE PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative Experiences of adversity, including racism and discrimination, among pregnant women is a substantial public health concern that impacts their functioning and outcomes in their offspring. The proposed supplement examines Black/White racial disparities in perinatal experiences and outcomes among women with substance use histories, as well as the interaction of discrimination and perinatal adversity on Black women’s functioning. This work will provide a better understanding of the effects of pre- and postnatal factors that impact maternal functioning and infant health and developmental outcomes.

PI_NAMEs: FOX, NATHAN A (contact);HARDEN, BRENDA J;RIGGINS, TRACY L.

PROJECT_TERMS: 10 year old;Acceleration;Adverse event;adverse maternal outcomes;Behavioral;Biological;Black race;black women;Brain;career;Caucasians;Child Development;Cognitive;Data;Data Set;Development;Discrimination;Disparity;early life adversity;Economics;Educational Status;Emotional;experience;fetal substance exposure;food insecurity;Genetic;Helping to End Addiction Long-term;Household;Immigration;improved;indexing;Infant;Infant Health;infant outcome;intimate partner violence;Link;Low income;Marital Status;Maternal Exposure;Maternal Health;Mental Depression;Mental Health;Morbidity - disease rate;neighborhood safety;Neighborhoods;offspring;Opiate Addiction;Opioid;opioid misuse;Outcome;parent grant;Perinatal;physical conditioning;postnatal;Pregnancy;Pregnant Women;Premature Infant;prenatal;prenatal experience;Prevention;Public Assistance;Public Health;racial disparity;racism;Recording of previous events;Research;Risk;Role;social;Social support;sociodemographic factors;Speed;Stress;substance use;training project;trauma exposure;United States National Institutes of Health;White Women;women's outcomes;Work

PROJECT_TITLE: 16/24 Healthy Brain and Child Development National Consortium HEAL Diversity Supplement


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health

PHR: Growing evidence demonstrates that secure attachment in childhood predicts children’s healthy social, biological, and behavioral functioning, whereas insecure attachment predicts behavior problems and physiological dysregulation; thus, efforts to foster secure attachment are crucial for promoting the healthy development of children and families. This proposal describes a randomized controlled trial (RCT) of an innovative intervention program that can be widely implemented designed to foster children’s secure attachment, promote healthy physiological regulation, and reduce the risk for behavior problems: The Circle of Security – Parenting intervention. To this end, we will conduct an RCT with 249 parent-child dyads enrolled in two diverse Early Head Start programs.

PI_NAMEs: CASSIDY, JUDE A (contact);WOODHOUSE, SUSAN SOLEDAD

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Adaptive Behaviors;Address;Adverse effects;Area;behavior prediction;Behavioral;Berlin;Biological;Buffers;caregiving;Child;Child Behavior;Child Development;Child Mental Health;Child Rearing;Childhood;Collaborations;Communities;depressive symptoms;design;Development;Distress;early life stress;Effectiveness of Interventions;efficacy testing;efficacy trial;Emotional;Emotions;Enrollment;Environment;Evaluation;experience;Exposure to;Family;follow-up;foster child;Fostering;Foundations;Goals;group intervention;Head Start Program;Health;high risk;hypothalamic-pituitary-adrenal axis;implementation efforts;Infrastructure;innovation;Intervention;intervention effect;intervention program;Learning;Light;Link;Low income;Maternal Behavior;Mediating;Mediation;Mental Depression;Meta-Analysis;National Institute of Child Health and Human Development;Neighborhoods;Outcome;Parent-Child Relations;parenting intervention;Parents;physical conditioning;Physiological;post intervention;prevent;Prevention;Prevention Protocols;Problem behavior;Protocols documentation;Psychopathology;psychosocial adjustment;Public Health;Randomized, Controlled Trials;Recovery;Regulation;Research;resilience;Resources;response;Risk;Risk Factors;Risk Reduction;Risk Reduction Behavior;Sampling;Secure;Security;service delivery;Services;social;Source;Stress;stressor;Temperament;Testing;theories;therapy design;Trauma;Treatment Efficacy;violence exposure;Work

PROJECT_TITLE: Prevention of Attachment Insecurity, Physiological Dysregulation, and Child Behavior Problems

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Project Narrative PACS1 R203W pathogenic substitution is solely responsible for over 200 patients presenting with the ASD- associated disease, PACS1 Syndrome, yet the mechanisms that lead to the neurodevelopmental defects remain largely unknown. Moreover, genome-wide association studies (GWAS) identified the human PACS1 locus as a susceptibility gene in severe early-onset obesity, developmental delay, and bipolar disorder, suggesting a broader role in neural development and function. In this proposal, we will use modern molecular biology and stem cell techniques combined with neuroscience tools to better understand the pathogenic mechanisms by which PACS1 deficits affect the developing nervous system, possibly revealing convergent therapy targets.

PI_NAMEs: GUEMEZ GAMBOA, ALICIA DIONE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Address;Affect;autism spectrum disorder;Bipolar Disorder;Brain;cancer cell;Cell Nucleus;Cell Physiology;Cerebrum;Chromatin;Complex;Data;Data Set;Defect;Development;Developmental Delay Disorders;Disease;effective therapy;Equilibrium;Etiology;Family;Gene Expression;Genetic;genome wide association study;Glutamates;Health;Histone Deacetylase;Human;Impaired cognition;Individual;Knowledge;Modernization;Molecular;Molecular Biology;nerve stem cell;Nervous System;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurologic;Neurons;Neurophysiology - biologic function;Neurosciences;Nuclear;Nuclear Localization Signal;Organoids;PACS1 Syndrome;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Pattern;Phenotype;programs;Proteins;Research;research and development;Role;S phase;severe early onset obesity;single-cell RNA sequencing;Sorting;Specific qualifier value;stem cells;Structure;Susceptibility Gene;targeted treatment;Techniques;Testing;tool;trans-Golgi Network;transcriptome;Variant;Work

PROJECT_TITLE: Identifying pathogenic mechanisms underlying PACS1 Syndrome: implications for neural development - Research Supplement to PromoteDiversity in Health-Related Research #2

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative (of Parent Grant 1-R01 NS131399-01) Developmental and epileptic encephalopathies (DEE) are a devastating group of neuropsychiatric disorders where seizures (that begin early in life) and an underlying genetic mutation or brain lesion result in developmental delay, intellectual disability and a complex spectrum of neurobehavioral disturbances. In this proposal, we apply a mouse model of DEE to clarify the molecular and circuit-level mediators underlying such behavioral syndromes using a novel homecage approach to measuring mouse behavior.

PI_NAMEs: KRISHNAN, VAISHNAV  (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Ablation;Arousal;Behavior;behavior measurement;Behavior Therapy;Behavioral;Biological Assay;Biological Models;Brain;Calcium;Clinical Trials;Cognitive;Communication;comorbidity;Complex;Deterioration;Development;Developmental Delay Disorders;developmental genetics;digital;Dissociation;DNA Sequence Alteration;drug discovery;Electroencephalography;Emotional;Encephalopathies;Epilepsy;epileptic encephalopathies;ergonomics;exome sequencing;experimental study;feeding;Foundations;Functional disorder;Genetic;Genome;Hippocampus;Home;Human;Hyperactivity;Image;Impairment;improved;In Situ;innovation;insight;instrumentation;Intellectual functioning disability;Lesion;Life;Measurement;Measures;Mediator;Modeling;Molecular;motor deficit;mouse model;Mus;Mutant Strains Mice;neurobehavioral;neuropsychiatric disorder;neuropsychiatry;novel;parent grant;Patient Care;Patients;Personal Satisfaction;pharmacologic;pre-clinical;Precision therapeutics;Process;Recurrence;Rodent;Seizures;sensory integration;Shapes;Sleep;Sleeplessness;social reciprocity;Spontaneous Remission;Syndrome;synergism;Telemetry;Testing;Therapeutic;transcription factor;wearable device;Work

PROJECT_TITLE: Dissecting the Developmental and Epileptic Components of Encephalopathy in DEE


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Somatic point mutations are very frequent in the context of several human genetic diseases but their causes are still poorly understood. Within the scope of the funded parent grant, this application aims at performing computational analyses on existing data on mutational signatures to better define the origins of different mutational signatures across mutagens and conditions. The other main goal of this application is to foster scientific and educational training for Dr Paolo Mita to promote his future academic career.

PI_NAMEs: BOEKE, JEF D;DAVOLI, TERESA  (contact);PETLJAK, MIA

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Cancer cell line;carcinogenesis;career;cell type;Cells;Chromosome Mapping;Communities;Computer Analysis;Data;Disease;DNA Damage;DNA Repair;DNA Sequence Alteration;Environmental Risk Factor;Exposure to;Fostering;Frequencies;Funding;Future;gain of function;Genes;Genetic;Genetic Diseases;Genetic Screening;Genetic study;Goals;Health;Human;human disease;Human Genetics;human tissue;innovation;Knowledge;Lead;Left;loss of function;Mammalian Cell;Methods;model organism;Mutagenesis;Mutagens;Mutation;novel;parent grant;Point Mutation;Process;Reporter;Tissues;Training and Education;Writing

PROJECT_TITLE: Davoli/Mita Diversity Supplement

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Social Determinants of Health

PHR: Project Narrative Heart failure diagnosis and treatment in Uganda faces significant challenges due to limited specialist availability and resources. The candidate, leveraging her background in global health and echocardiography training of non-specialists in Haiti, aims to address these issues through the co-design of an Echocardiography Training Intervention Package tailored for non-specialists in six Regional Referral Hospitals in Uganda. This project, by improving the early detection of heart failure and studying Guideline-Directed Medical Therapy prescribing practices, seeks to enhance patient outcomes and advance heart failure care practices in Uganda.

PI_NAMEs: CAFAZZO, JOSEPH ANTONY;SCHWARTZ, JEREMY IAN (contact);SSINABULYA, ISAAC

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Cardiovascular system;Caring;Clinical;Community of Practice;design;Diagnosis;digital;Early Diagnosis;Early identification;Echocardiography;Educational Intervention;experience;Face;Funding;global health;Goals;Guidelines;Haiti;health care delivery;Healthcare;Heart failure;heart failure with reduced ejection fraction;High Prevalence;Hospital Referrals;implementation science;improved;improved outcome;Lead;Logistic Regressions;Longitudinal cohort;Medical;Medicine;Mentorship;Modeling;National Heart, Lung, and Blood Institute;Outcome;parent grant;Parents;Patient-Focused Outcomes;Patients;professor;programs;Research Personnel;Resources;Self Care;Site;sociodemographic disparity;Specialist;Training;trend;Uganda;Work

PROJECT_TITLE: Optimization of echocardiography training and guideline-directed medical therapy for heart failure within a digital-first self-care program in Uganda

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE: The use of population descriptors is important to the interpretation of clinical genomic research across populations. This project will expand population descriptors included in the CHOP eMERGE cohort to include geographic descriptors and evaluate the perceived utility of descriptors in genomic professionals and trainees.

PI_NAMEs: HAKONARSON, HAKON  (contact)

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academy;Address;algorithmic bias;Algorithms;Assessment tool;Asthma;biobank;Budgets;built environment;Categories;Characteristics;Childhood;Classification;Classification Scheme;Clinical;cohort;Communities;Computerized Medical Record;Data;Data Set;Descriptor;Development;Dimensions;DNA;Electronic Medical Records and Genomics Network;Ensure;Equity;Ethnic Origin;Evaluation;Genetic;genomic data;Genomic medicine;Genomics;Geography;Goals;health disparity;Healthcare;improved outcome;indexing;Individual;informant;innovation;insight;Insulin-Dependent Diabetes Mellitus;interest;Interview;Learning;Measures;Minority;Modeling;National Human Genome Research Institute;Nationalities;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Participant;Pediatric Hospitals;Philadelphia;polygenic risk score;Population;population based;Population Heterogeneity;Prevention;Provider;Publications;Race;Recommendation;Reporting;Research;Research Personnel;Risk;Risk Assessment;social computing;social health determinants;social vulnerability;Structure;study population;Suggestion;tool;training data;type I and type II diabetes

PROJECT_TITLE: Utilizing Polygenic Risk to Understand and Improve Outcomes: A Model for Overturning Health Disparities Through Minority-Enriched Genomics Healthcare


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Telehealth

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE/ RELEVANCE OF PROJECT TO RESEARCH AND PUBLIC HEALTH Widespread utilization of genomic sequencing in medicine creates an urgent need to educate providers and patients. Currently, providers frequently misinterpret genomic information and patients often don't understand their own test results. In order to address this critical need, we propose to design and test multiple e-Health communication tools that will help providers and patients to better understand genomic data, lead to higher quality patient care, and facilitate genomic information sharing within families.

PI_NAMEs: GRAY, STACY W. (contact)

PROGRAM_OFFICER_NAME: LOCKHART, NICOLE C

PROJECT_TERMS: Address;Administrative Supplement;Area;Attitude;Caring;Cessation of life;Clinic;clinical care;clinical practice;Communication;Communication Tools;Community Physician;Data;design;disorder prevention;disorder risk;Effectiveness;effectiveness testing;eHealth;Environment;Excision;exome;Family;Family member;Genetic;genome sequencing;genomic data;Genomic medicine;genomic platform;Genomics;Health;Healthcare;Human Genome;improved;Information Networks;Intervention;Interview;Lead;Malignant Neoplasms;Medicine;Methods;multidisciplinary;National Human Genome Research Institute;Natural Language Processing;online resource;Organ;Patient Care;Patients;Persons;Physicians;pilot test;Positioning Attribute;premature;Process;Provider;Public Health;Randomized, Controlled Trials;Research;Research Priority;Resources;Risk;Secure;Social Network;Spanish;Test Result;Testing;tool;Translating;uptake;Vision;whole genome;Work

PROJECT_TITLE: Scalable tools to effectively translate genomic discoveries into the clinic : Administrative Supplement


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Astrocytes, the most abundant glial cells in the central nervous system, perform a multitude of evolutionary conserved functions including, metabolic support to neurons, regulating blood-brain barrier, and modulating synapse-formation, -function and -plasticity, and are crucial in maintaining normal brain homeostasis. Dynamic crosstalk between astrocytes and neuronal synapses modulates most if not all of these functions, yet the molecular mechanism of neuron-astrocyte cross-communication at the synapse is largely untapped. Based on our preliminary studies, we propose a novel mechanism of neuron-astrocyte crosstalk at the synapse via S1P/S1PR1 signaling that regulates astrocyte function and neuronal synapse formation, function and plasticity.

PI_NAMEs: SINGH, SANDEEP KUMAR (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Astrocytes;Blood - brain barrier anatomy;Brain;Brain Diseases;Brain Pathology;Calcium;Central Nervous System;Communication;Coupled;Data;Development;Drug Targeting;Excitatory Synapse;Funding;Glutamates;Glypican;Goals;GTP-Binding Proteins;hevin;Homeostasis;In Vitro;in vivo;insight;Knock-out;Knowledge;Link;Mediating;Metabolic;Molecular;Morphogenesis;Morphology;Mus;Nervous System Disorder;neural circuit;Neuroglia;neuronal circuitry;neuronal growth;neuronal survival;Neurons;neuropathology;neurotransmission;novel;parent project;Process;Protein Secretion;Proteins;Publishing;receptor;Research;Role;Shapes;Signal Pathway;Signal Transduction;Sphingolipids;sphingosine 1-phosphate;sphingosine kinase;Sphingosine-1-Phosphate Receptor;Structure;Synapses;synaptic function;synaptogenesis;Testing;thrombospondin 4;Thrombospondins;underrepresented minority student;vesicular glutamate transporter 2

PROJECT_TITLE: URM Student supplement  - R01 NS126504 SSingh

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: NEW ORLEANS

ORG_NAME: LSU HEALTH SCIENCES CENTER

ORG_STATE: LA

PHR: NARRATIVE The overall vision of the “Kaposi Sarcoma in the Era of ART in Africa Program (KEAAP)” is to build a collaborative network between the Cancer Diseases Hospital and the University Teaching Hospitals in Zambia, the Ocean Road Cancer Institute in Tanzania, and the Stanley S Scott Cancer Center at the Louisiana State University Health Sciences Center-New Orleans, to conduct cutting edge research that will lead to a better understanding of Kaposi sarcoma, a common HIV associated cancer in Africa. KEAAP is high impact because it builds on successful ongoing Fogarty and NCI training programs, it will implement a cross-disciplinary tri- lateral research and training program driven by our Tanzanian and Zambian collaborators with broad local support to ensure their sustainability. The lessons learned will also benefit Louisiana HIV-1 and cancer research since the state has the fifth largest population of people living with HIV, mostly among its health disparities population.

PI_NAMEs: MWAISELAGE, JULIUS DAVID;NGALAMIKA, OWEN ;WOOD, CHARLES  (contact)

PROGRAM_OFFICER_NAME: KALEEBA, JOHNAN AUGUSTINE

PROJECT_TERMS: Address;Africa;Africa South of the Sahara;AIDS related cancer;anti-cancer research;antiretroviral therapy;Bilateral;Cancer Biology;Cancer Center;Cancer Patient;Cancer Research Infrastructure;Caring;Chronic;clinical care;Collaborations;Core Facility;Country;Detection;Diagnosis;Disease;Educational workshop;Ensure;Epidemic;Etiology;Fostering;Funding;Future;Goals;health disparity populations;Health Sciences;HIV;HIV-1;HIV/AIDS;Hospitals;Human Herpesvirus 8;Human Resources;immune activation;Immune response;Immunosuppression;Incidence;Individual;Kaposi Sarcoma;Lateral;Lead;Leadership;Link;Louisiana;low and middle-income countries;Malignant Neoplasms;Mediating;Mentors;metabolome;Molecular;next generation;Oceans;Oncology;Outcome;Pathogenesis;Pathology;Patients;Persons;Pilot Projects;Population;Positioning Attribute;prevent;programs;Public Health;Research;Research Infrastructure;Research Personnel;Research Project Grants;Residual state;Staging;success;Tanzania;Teaching Hospitals;Technology Transfer;Tissues;Training;Training Activity;Training and Infrastructure;Training Programs;United States;Universities;Viral;Vision;Zambia


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lung;Pediatric;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The supplement aims to support Sally for two years to help build a strong foundation in research before applying for graduate school. Under the mentorship and guidance of Dr. Neeta Thakur, Sally will contribute to the EXposomic Profiling in Airway disease to uNravel Determinants of disease (EXPAND) Asthma study that aims to explore how underrepresented children and adolescents with and without asthma respond to social exposures like poor air quality.

PI_NAMEs: CHRISTENSON, STEPHANIE A (contact);THAKUR, NEETA

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: 16 year old;Acute;Admission activity;Adolescent;Affect;Age;Air;air monitoring;Airway Disease;ambient air pollution;Asthma;asthma exacerbation;California;career;career development;Caregivers;Child;Childhood Asthma;climate change;Collection;Color;Communities;community engagement;Community Health;community partners;Coupled;Data;Data Analyses;Data Element;Data Set;Dedications;Disease;Ensure;Environmental Exposure;environmental justice;Exposure to;Family;Fellowship;fine particles;Foundations;Future;Goals;graduate school;Health;Heterogeneity;Home;Housing;Infiltration;Inflammation;Inflammatory;International;Intervention;Interview;knowledge base;Manuscripts;matriculation;Measures;Mentors;Mentorship;Monitor;Morbidity - disease rate;Paper;parent grant;Parents;Participant;participant enrollment;Pathway interactions;Predisposition;Process;Program Development;programs;Psychosocial Stress;Publishing;Qualitative Methods;recruit;Reporting;Research;research and development;Research Methodology;Research Personnel;Role;Sampling;San Francisco;Services;skills;Smoke;social;social relationships;social stress;social stressor;study population;symposium;Technical Expertise;Time;Time trend;Training;undergraduate student;United States;Universities;Wildfire;Work;Writing

PROJECT_TITLE: EXposomic Profiling in Airway disease to uNravel Determinants of disease in Asthma (EXPAND-Asthma) Center


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: EL CERRITO

ORG_NAME: MAGNETIC TIDES, INC.

PHR: Project Narrative We have recently developed a new non-invasive brain stimulation (NIBS) system, kilohertz transcranial magnetic perturbation (kTMP), that opens a new experimental space for safely modulating neural excitability in targeted areas of the human brain. This project will focus on building and testing an instrumented glove designed to capture detailed motor performance during a reach-to-grasp task. In addition, the supplementee will carrying out an engineering gap analysis to create a Formal Design History File for kTMP that is necessary to prepare a Premarket Submission to the FDA.

PI_NAMEs: LABRUNA, LUDOVICA  (contact)

PROGRAM_OFFICER_NAME: FORBES, JESSICA CARLENE

PROJECT_TERMS: Appointment;Area;Behavioral;Biomedical Engineering;Brain;career;Career Choice;Cephalic;Characteristics;design;Device or Instrument Development;Engineering;experience;experimental study;Frequencies;Goals;grasp;Human;improved;instrument;Leadership;magnetic field;Magnetism;Marketing;Measurement;Medical Device;Motor;Motor Skills;Movement;neural;noninvasive brain stimulation;parent grant;Participant;Performance;Physiological;pre-doctoral;Recording of previous events;Regulation;Research Project Grants;System;Technology;technology development;Testing;Time;Training

PROJECT_TITLE: Exploring the Parameter Space of High Frequency Magnetic Perturbation in Manipulating Neural Excitability and Plasticity.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]