ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Telehealth;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative This project will develop a One Health mHealth platform to improve detection of zoonotic spillover in the Bwindi region of southwestern Uganda. It will be applicable to other sub-Saharan regions and help answer questions regarding the ecological scenarios supporting ebolavirus emergence, enabling forecasting to prevent future outbreaks.

PI_NAMEs: EVANS, TIERRA SMILEY (contact);KELLERMANN, ALAN SCOTT;WILKES, MICHAEL S

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Acute;Address;Africa;Africa South of the Sahara;Antibodies;Biodiversity;Border Community;Cellular Phone;Chikungunya virus;Chiroptera;Collaborations;Communicable Diseases;Communication;Communities;Congo;dashboard;Data;Data Analytics;Data Collection;data dissemination;data streams;deep neural network;Democratic Republic of the Congo;Dengue Fever;design;Detection;Disease;Disease Outbreaks;Disease Surveillance;Early Diagnosis;Early identification;Ebola Hemorrhagic Fever;Ebola virus;Ecosystem;electronic data;Emerging Communicable Diseases;emerging virus;Epidemiology;Event;falls;Fever;Filovirus;forest;Funding;future outbreak;Goals;Health;Health care facility;health data;health empowerment;Health Personnel;Health Professional;Hospitals;Household;Human;human data;Human Resources;Immunoglobulin G;improved;Incidence;Infrastructure;Machine Learning;machine learning algorithm;Marburg Virus Disease;member;Methods;mHealth;Modeling;Monitor;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;new outbreak;next generation;Outcome;pandemic potential;pathogen;Patients;Pattern;Phase;Population;preempt;prevent;prevent outbreaks;Primates;programs;Proliferating;prospective;Reaction Time;remote communities;Reporting;Research;Risk;Risk Factors;Sampling;smartphone application;Specimen;spillover event;surveillance network;Surveillance Program;System;Systems Analysis;Technology;technology platform;Telephone;Testing;Time;tool;trend;Uganda;Virus;Yellow Fever;Zika Virus;Zoonoses;zoonotic spillover

PROJECT_TITLE: Advancing One Health Data Capture at the Point of Zoonotic Spillover in the Congo Basin Forest Perimeter


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;Lung;Mental Health;Rare Diseases;Rehabilitation

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The vast majority of adults with Acute Respiratory Failure (ARF) in the U.S. survive, but many experience new and persistent physical, cognitive, and mental health impairments and >50% remain dependent on family caregivers who also experience elevated levels of depression. This study will clarify the relationship between expectations for recovery, self-efficacy, mental health, and coping behaviors in ARF survivor-care partner dyads. Using a mixed methods approach, we will identify modifiable factors that contribute to better mental health and dyadic coping to inform the development of a dyadic coping intervention.

PI_NAMEs: PARKER, ANN MARIE;TURNBULL, ALISON  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Activities of Daily Living;Acute respiratory failure;Adult;Aging;anxiety symptoms;behavior influence;Caregivers;Caring;Chronic;Clinical;Cognitive;Communities;coping;Coping Behavior;COVID-19 pandemic;Critical Care;critical care nursing;Critical Illness;Dementia caregivers;depressive symptoms;Development;Effectiveness;emotional distress;Enrollment;Evidence based intervention;expectation;experience;Family;Family Caregiver;Feedback;Financial Hardship;follow-up;Funding;Future;Goals;Health;Health behavior;health care service utilization;health management;Health Status;Heart Diseases;High Prevalence;Hospitalization;Hospitals;Impaired health;improved;innovation;International;Intervention;Intervention Trial;Interview;Learning;Longitudinal cohort study;Malignant Neoplasms;Managed Care;member;Mental Depression;Mental Health;Methods;Nature;older adult;Outcome;participant retention;Patients;persistent symptom;Population;Positioning Attribute;primary outcome;programs;prospective;Prospective, cohort study;Psychology;Quality of life;Race;Recovery;Rehabilitation therapy;Reporting;Research;Research Methodology;response;Sampling;secondary outcome;Self Efficacy;Shapes;skills;socioeconomics;Structure;success;Surveys;Survivors;survivorship;Symptoms;systematic review;Telephone;Testing;Time;United States National Institutes of Health;Variant;Work

PROJECT_TITLE: Health expectations after acute respiratory failure in survivor-care partner dyads

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  This project combines the expertise of three laboratories to identify genes regulated by the Bordetella PlrSR two-component regulatory system. Our recent data indicate that one or more PlrSR-regulated genes is critical for bacterial survival in the lower respiratory tract. The gene products could serve as therapeutic targets or new vaccine components for treating or preventing pertussis (aka whooping cough), a serious respiratory illness that is increasing in the United States and other countries that use acellular pertussis vaccines.

PI_NAMEs: BOURRET, ROBERT B.;COTTER, PEGGY A (contact);JULIO, STEVE

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acellular Vaccines;Binding Sites;Biochemical;Biochemistry;Bordetella;Bordetella bronchiseptica;Bordetella Infections;Bordetella pertussis;Bypass;Carbon Dioxide;ChIP-seq;Collaborations;Country;Dangerousness;Data;Data Analyses;Disease;Epitopes;Expert Systems;Foundations;Future;Gene Expression;gene product;Genes;Goals;high reward;Homologous Gene;Human;Immune response;improved;In Vitro;in vivo;Infant;Infection;insight;Investigation;Knowledge;Laboratories;Link;Lower Respiratory Tract Infection;Lower respiratory tract structure;Mammals;Measures;Methods;model organism;Molecular Biology;Mus;novel vaccines;Oxidative Stress;Pathogenesis;Pertussis;Pertussis Vaccine;Physiological;Population;prevent;Probability;Production;Proteins;Public Health;Quantitative Reverse Transcriptase PCR;Regulation;Regulon;Reporter;Repression;respiratory;Respiratory Disease;respiratory pathogen;response;Risk;Role;Sensory;Signal Transduction;Stimulus;Study models;System;Therapeutic;therapeutic target;Time;Training;transcriptome sequencing;transmission process;trend;United States;Vaccinated;vaccine access;vaccine candidate;Vaccinee;Vaccines;Virulence;Virulence Factors

PROJECT_TITLE: Identifying the Bordetella PlrSR regulon

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE This renewal application builds on our successful execution of the RAPID EC (RCT Assessing Pregnancy with Intrauterine Devices for Emergency Contraception) trial, which demonstrated the levonorgestrel (LNG) 52 mg IUD is effective for emergency contraception (EC) and can be placed throughout the menstrual cycle, with a negative pregnancy test. This project will test the reproducibility and generalizability of our data in “real world” clinical situations, in 8 sites across the U.S. With a larger and more heterogenous population, this work could favorably impact millions of people’s IUD access globally.

PI_NAMEs: TUROK, DAVID  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, STEVEN

PROJECT_TERMS: Adopted;American College of Obstetricians and Gynecologists;Binding;Caring;Clinical;clinical application;clinical care;Collaborations;Contraceptive Agents;Contraceptive methods;Copper;Copper Intrauterine Devices;cost;Data;data access;design;Effectiveness;effectiveness evaluation;effectiveness study;emergency contraception;Enrollment;ethnic diversity;Exclusion;gender diversity;Geographic Locations;Geography;Goals;Guidelines;Health;Home;inclusion criteria;Individual;Intrauterine Devices;Journals;Justice;Levonorgestrel;Medical;Medicine;Menstrual cycle;Menstruation;Methods;New England;Outcome;Participant;Persons;Planned Parenthood Federation of America;Population;Population Heterogeneity;Practice Guidelines;Pregnancy;Pregnancy Rate;Pregnancy Tests;prevent;primary outcome;Privatization;prospective;Publications;Publishing;racial diversity;Recommendation;Recording of previous events;Reporting;Reproducibility;reproductive;Research Infrastructure;Research Personnel;Risk;Site;standard of care;Testing;Time;United States National Institutes of Health;Unsafe Sex;Urine;Work

PROJECT_TITLE: Levonorgestrel IUD for Emergency Contraception & Same-Day Start Study

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE To improve early access to pre-emergency care for pediatric patients, a telemedicine and medication delivery service (TMDS) is a promising innovative alternative to conventional approaches. Our objectives are to: (i) develop an electronic clinical decision support (eCDS) tool for a TMDS, (ii) derive a disease severity prediction (DSP) algorithm to enhance the eCDS for accurate triage and escalation of care, and (iii) externally validate the DSP and evaluate the eCDS in a pilot stepped wedge cluster randomized trial. This single-site study will provide essential experience and metrics for a future multi-site randomized controlled trial of the DSP integrated into the eCDS.

PI_NAMEs: NELSON, ERIC JORGE (contact)

PROJECT_TERMS: 5 year old;Acute respiratory infection;Address;Area;Artificial Intelligence;Caring;Cessation of life;Child;Child Care;Childhood;Clinical;clinical decision support;Clinical Pathways;Cluster randomized trial;Communities;Complex;Data;Databases;Derivation procedure;design;diarrheal disease;Disease;Electronics;Emergency Care;Emergency medical service;Emergency Situation;Environment;Evaluation;Event;experience;Funding;Future;Ghana;Goals;Guideline Adherence;Guidelines;Haiti;health care availability;health care delivery;Health Services Accessibility;Hospital Referrals;Hospitals;Household;human centered design;implementation science;improved;Infrastructure;innovation;Intervention;Knowledge;Location;Logistics;Methods;mHealth;Modeling;Morbidity - disease rate;mortality;novel;Outcome Measure;Paper;Participant;Pathway interactions;Patients;pediatric patients;Performance;Persons;Pharmaceutical Preparations;Pilot Projects;prediction algorithm;primary outcome;Probability;prototype;Provider;Qualitative Research;Randomized, Controlled Trials;Research;Research Design;Resource-limited setting;Resources;Safety;Sensitivity and Specificity;service delivery;Service delivery model;Services;Severities;Severity of illness;Site;statistical learning;Stress Tests;success;support tools;Technology;Telemedicine;Treatment Cost;treatment planning;Triage;United States National Institutes of Health;USAID;Validation;virtual;Virtual Tool;World Health Organization

PROJECT_TITLE: Improving Performance of a Pediatric TeleMedicine and Medication Delivery Service through mHealth Technology


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Women are more represented within obese and extremely obese classifications, and women and girls are three times more likely to engage in disordered eating than men and boys. Here we propose studies to understand sex differences in the neural circuit that regulates feeding, specifically how an understudied population of neurons can modulate the effects of estrogens on food intake. Ultimately, these neurons may be critical modulators of the effects of estrogens that can be exploited to treat obesity and eating disorders in women.

PI_NAMEs: CORREA, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;anorexic;Behavior;boys;Brain;Caspase;Cavia;Cell Nucleus;Cells;Classification;Cues;Data;Dependence;Diet;disorder risk;Eating;Eating Disorders;energy balance;Energy Metabolism;Estradiol;Estrogens;Estrous Cycle;Exclusion;Exhibits;Fatty acid glycerol esters;feeding;Feeding behaviors;Female;Flow Cytometry;Genetic Transcription;girls;Goals;Gonadal Hormones;Gonadal Steroid Hormones;Health;Human;Hunger;Hypothalamic structure;immunoreactivity;Label;male;Masks;Mediating;men;Menopause;Menstrual cycle;Metabolic;Morbid Obesity;Mus;neural circuit;Neurons;neuroregulation;Obesity;Peripheral;permissiveness;Phase;Physiology;Population;Proestrus;Rattus;Regulation;Reporting;reproductive;Research;Role;sex;Sex Differences;sex variable;Signal Transduction;Somatostatin;sugar;Testing;transcriptome sequencing;Transplantation;Wild Type Mouse;Woman

PROJECT_TITLE: Hypothalamic gating of the anorexic effects of estradiol

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Telehealth

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The economic, environmental and health infrastructure in cities is not equally distributed nor sufficient to serve this growing urban population. Poor urban sanitation is responsible for disproportionate health impacts especially in underserved communities. mHealth has tremendous potential to engage and include underserved populations to increase access to inclusive sanitation solutions resulting in positive impacts on health and well-being.

PI_NAMEs: COSTA, FEDERICO ;STAUBER, CHRISTINE ELIZABETH (contact)

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accountability;Address;Adherence;Adoption;behavior change;Behavioral;Brazil;Cessation of life;Cities;climate change;Communication;Communities;community based participatory research;community engagement;Community Participation;cost effective;Country;Data;disability-adjusted life years;disorder risk;Disparity;Dose;Economics;Educational workshop;Effectiveness;Emerging Communicable Diseases;Environmental Impact;environmental intervention;Environmental Pollution;Equity;ethnic health disparity;Exclusion;experience;Focus Groups;Goals;Government;Health;Health Services;Health Technology;Healthcare;Household;Housing;Hygiene;improved;Infrastructure;innovation;Intervention;Interview;Investigation;Investments;Link;low and middle-income countries;Maintenance;marginalization;Measurement;Measures;member;Mental Health;mHealth;migration;Neighborhoods;Observational Study;operation;Personal Satisfaction;Persons;Population;primary outcome;process evaluation;Program Effectiveness;programs;Public Health;Quality of life;racial health disparity;Research;Research Design;Resources;Sanitation;satisfaction;scale up;Secure;service providers;Services;Slum;Solid;Surveys;Sustainable Development;System;underserved community;Underserved Population;uptake;urban area;Urban Community;Urban Population;urban setting;urban underserved;Urbanization;validation studies;vulnerable community;Vulnerable Populations;wasting;Water

PROJECT_TITLE: Environmental and Sanitation Improvements with mHealth


ADMINISTERING_IC: AG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Racial and ethnic minorities – especially American Indians, Alaska Natives, Native Hawaiians, and Pacific Islanders – are underrepresented in health research. The Community Health and Aging in Native Groups of Elders Resource Center for Minority Aging Research is training program that focuses on community-based research with Native communities. It will also implement the National Institute on Aging’s mandate to increase the diversity of investigators conducting research with Native populations in the US.

PI_NAMEs: BALDWIN, JULIE ANN;DILLARD, DENISE A (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Aging;aging related;Alaska Native;Aleut;American Indians;Arizona;career;Cherokee Nation;Chippewa;Choctaw;cohort;Colorado;Communities;community based research;community engagement;Community Health;Community Health Education;Community Integration;Community Outreach;community partners;Development;Doctor of Philosophy;early-career faculty;Education;education research;Educational Curriculum;Eels;Elderly;Ensure;Epidemiologist;equity, diversity, and inclusion;ethnic minority;experience;Faculty;Funding;Goals;Hawaii;Health;improved;Individual;innovation;Institution;Intervention;Lead;Leadership;Letters;Literature;Mentors;Minnesota;Minority;minority investigator;National Institute on Aging;native elder;Native Hawaiian or Other Pacific Islander;Native-Born;Oklahoma;Outcome;Parents;Participant;Persons;Pilot Projects;Population;prevent;Principal Investigator;programs;promoter;Publications;racial minority;Records;recruit;Research;Research Institute;Research Personnel;Resources;role model;Scientist;senior faculty;skills;success;supportive environment;Time;Training;Training Programs;Trust;Underrepresented Minority;underserved community;Universities;Update;Washington

PROJECT_TITLE: Community Health and Aging in Native Groups of Elders Resource Center for Minority Aging Research (CHANGE RCMAR)


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Pediatric

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE If healthy babies are sequenced near birth, when should genetic information relevant to later stages of their lives be revealed? There are different possible strategies for when this genomic information is revealed, and this research will determine their clinical feasibility, analyze their ethical, legal and social implications, understand diverse parents' preferences, and seek consensus on the necessary and desirable features of a strategy. The project will generate concrete recommendations for implementers of newborn sequencing and will hence help ensure the ethical rollout of genomic medicine for all.

PI_NAMEs: LEWIS, ANNA  (contact)

PROGRAM_OFFICER_NAME: KAUFMAN, DAVE J

PROJECT_TERMS: Address;Adoption;Adult;Age;Attitude;Birth;career;Child;Childhood;Clinical;Clinical Research;Clinical Trials;cohort;Complex;Consensus;Consent;Data;Decision Making;design;Development;Educational workshop;Enrollment;Ensure;Equilibrium;Equity;ethical, legal, and social implication;Ethics;evidence base;Future;gene-targeted therapy;Genetic;genetic counselor;Genetic Diseases;genetic information;Genetic Screening;genetic testing;Genome;Genomic medicine;Genomics;Goals;Government;Health;Health Personnel;Healthcare;Individual;Industry;Interview;Laboratories;Legal Obligations;life span;Medical;member;Mentors;Mentorship;Methodology;Methods;National Human Genome Research Institute;Newborn Infant;novel;Parents;Pediatric Oncologist;Policies;Population;preference;primary care provider;Privacy;Process;Provider;Recommendation;Registries;Reporting;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;Risk;Science;screening panel;Series;skills;Specific qualifier value;Structure;study population;Surveys;Technology;Testing;Time;Training;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: Identifying strategies to reveal genetic results over the lifespan


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health

PI_NAMEs: DILLARD, DENISE A (contact)

PROJECT_TERMS: Acceleration;Achievement;Adherence;Advisory Committees;Aging;Agreement;Alaska Native;Alaska Native population;Aleut;Alzheimer's Disease;American Indian Population;American Indians;Arizona;Budgets;Cherokee Nation;Chippewa;Collaborations;college;Colorado;Communication;Communities;community engagement;Community Health;Community Health Education;Community Integration;Community Outreach;community partners;Creativeness;distinguished professor;Doctor of Philosophy;Education;education research;Elderly;Ensure;experience;Faculty;federal policy;Funding;Health;Health equity research;Health Sciences;Healthcare Systems;Institution;Institutional Review Boards;Leadership;Learning;Medicine;Mentors;Methods;Minority;Minority-Serving Institution;Mission;Modeling;Monitor;native elder;Native Hawaiian or Other Pacific Islander;next generation;novel;Oklahoma;operation;Outcome;Participant;Pilot Projects;Principal Investigator;Procedures;process evaluation;professor;Program Reviews;programs;Progress Reports;Proverb;Provider;Publishing;recruit;Research;Research Institute;Research Personnel;Resources;Scholarship;Science;Scientist;Senior Scientist;Sioux Indians;Strategic Planning;Tribes;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MACLEHOSE, RICHARD F (contact)

PROJECT_TERMS: Acute;Adopted;Affect;Aging;Alaska Native;Alzheimer's Disease;American;American Indians;Anecdotes;Biometry;Black Populations;career;Career Mobility;Catalogs;Censuses;Chronic Disease;cohort;Collaborations;Communities;community based participatory research;community collaboration;community engaged research;Community Health;Community Integration;community partners;Creativeness;curriculum development;Data;Data Analyses;data quality;Death Certificates;Dedications;Demography;deprivation;Development;Dimensions;disorder risk;Ecology;Economics;Education;Educational Curriculum;Effectiveness;Elderly;empowerment;Epidemiologist;Epidemiology;Equity;Ethnic Population;Evaluation;experience;Expert Opinion;Faculty;Failure;flexibility;Funding;Genocides;Geography;Goals;Grant;hamstring;Hawaii;Health;health disparity;health equity;Healthcare;high risk;Hispanic Populations;Indigenous;Inequity;Instruction;Journals;Leadership;Life Expectancy;Measurement;Measures;member;men;Mentors;Minnesota;Minority;Minority Groups;Morals;native elder;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;novel;Personal Satisfaction;Persons;Pilot Projects;Population;Principal Investigator;Productivity;Program Evaluation;programs;public health research;Publications;Qualitative Methods;Qualitative Research;racial population;recruit;Reporting;Research;Research Design;research faculty;Research Methodology;Research Personnel;research study;Research Support;Resources;Scientist;senior faculty;Services;social health determinants;statistics;Structural Racism;success;Systematic Bias;Training;Trust;Underrepresented Minority;Underserved Population;United States National Center for Health Statistics;United States National Institutes of Health;Universities;virtual;Woman;Work;Writing

PROJECT_TITLE: Analysis Core


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative:  Heart failure (HF), the leading cause of death worldwide, is characterized by T-cell mediated inflammation and cardiac fibrosis. However, anti-inflammatory or anti-fibrotic therapies have not yet shown efficacy in the prevention or treatment of HF. The goal of this proposal is to study novel signaling pathways in T-cells that contribute to cardiac fibrosis and may result in new therapeutic targets in HF.

PI_NAMEs: BAYER, ABRAHAM  (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Adaptor Signaling Protein;Adhesions;Adoptive Transfer;Affect;Anti-Inflammatory Agents;antifibrotic treatment;Antigen Presentation;Antigens;aorta constriction;Binding;Cardiac;career;Cause of Death;Cell Adhesion;Cell Communication;Cell Death;cell injury;Cell Physiology;Cell Survival;Cells;Chronic;clinical training;coronary fibrosis;Data;Development;Doctor of Philosophy;effector T cell;Exhibits;Fibroblasts;Fibrosis;Functional disorder;Goals;Heart;heart damage;Heart failure;heart function;Heart Hypertrophy;Helper-Inducer T-Lymphocyte;Immune response;Impairment;improved;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Integrin alpha4;Interferon Type II;Interferon-beta;Interleukin-2;Investigation;Knock-out;lymphoid organ;Mediating;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;Myocarditis;Myofibroblast;new therapeutic target;novel;Pathway interactions;Patients;Pattern;Persons;Physicians;Prevention;Production;receptor;reconstitution;Research Training;response;restoration;Role;Scheme;Scientist;Signal Pathway;Signal Transduction;systemic inflammatory response;T cell infiltration;T cell reconstitution;T-Cell Activation;T-Cell Activation Pathway;T-Lymphocyte;Testing;TLR4 gene;TNF gene;Training;United States;Vascular Cell Adhesion Molecule-1;Work

PROJECT_TITLE: Comparing the role of MyD88 and TRIF in T-cell effector function and the development of heart failure


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: HEBERT, LUCIANA ESTELLE (contact)

PROJECT_TERMS: Academia;Acceleration;Address;Adopted;Advocate;Affect;Aging;Alaska Native;American;American Indians;Attention;Autobiography;career;career life balance;Career Mobility;Categories;Choctaw;cohort;Collaborations;Communities;community based participatory research;community engaged research;Community Health;Community Integration;community partners;Curiosities;Dedications;Development;didactic education;disability;disadvantaged background;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational workshop;Eels;Elderly;Ensure;Environment;equity, diversity, and inclusion;Ethnic Population;Extramural Activities;Faculty;Fostering;Funding;Goals;Grant;Growth;Hawaii;Health;health disparity;Health equity research;improved;indexing;innovation;Institution;Leadership;lens;Literature;marginalized population;Mentors;Minority;Minority Groups;minority investigator;Mission;native elder;Native Hawaiian or Other Pacific Islander;Oklahoma;Outcome;Parents;Participant;peer;peer networks;Peer Review;Persons;Pilot Projects;Play;Population;prevent;Principal Investigator;professor;programs;promoter;Publications;racial population;recruit;Reporting;Research;research faculty;Research Personnel;Research Project Grants;Resources;role model;Scholarship;Scientist;senior faculty;Series;Services;social;Structure;success;supportive environment;System;Training;Training Programs;Trust;Underrepresented Minority;United States National Institutes of Health;Universities;Washington;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Emergency Care;Physical Injury - Accidents and Adverse Effects

ORG_DEPT: SURGERY

PHR: Project Narrative The proposed research is relevant to public health because the development and validation of a smartphone- based ultrasound program for trauma aims to fill a critical deficit in existing diagnostic capacity and decrease preventable deaths among injured patients in Cameroon. If found to be feasible and effective, this approach would shift clinical practice patterns in this context. The research is relevant to NIH’s mission because it seeks to lengthen the lives of trauma patients.

PI_NAMEs: CHICHOM, ALAIN MEFIRE;CHRISTIE, SABRINAH ARIANE (contact)

PROJECT_TERMS: acceptability and feasibility;Area;Blinded;Cameroon;Caring;Cellular Phone;Cessation of life;Clinical Practice Patterns;cloud based;cohort;Collaborations;Competence;Consultations;cost;Country;Data Collection;Death Rate;design;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Imaging;Education;education evaluation;Educational Curriculum;Effectiveness;effectiveness evaluation;efficacy evaluation;encryption;Equipment;Failure;feasibility testing;Future;Goals;Health;Health system;Hemorrhagic Shock;Hospitals;Image;implementation facilitators;implementation protocol;improved;injured;Injury;injury burden;Interruption;Interventional Ultrasonography;Interview;Knowledge;Knowledge acquisition;Life;low and middle-income countries;Malaria;Methods;mHealth;Mission;Mobile Health Application;Modality;mortality;operation;Operative Surgical Procedures;Outcome;Patients;Performance;Phase;Population;preventable death;Procedures;programs;Provider;Public Health;radiologist;Registries;Research;research and development;scale up;Scanning;severe injury;Site;skill acquisition;skills;Standardization;Structure;Surveys;systems research;Testing;Time;Training;Trauma;trauma care;Trauma patient;Tuberculosis;Ultrasonography;ultrasound;United States National Institutes of Health;Validation

PROJECT_TITLE: Smartphone ultrasonography to improve diagnosis and treatment of life-threatening injuries for trauma patients in Cameroon


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Lung;Lung Cancer;Patient Safety;Physical Activity

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Frail older adult patients do better during and after surgery if they are in better condition before surgery, so an “app” with videos of exercises was created to help patients get in better condition by encouraging and tracking exercise. However, patients have never been asked to give feedback about the app, so this study will get feedback from frail older adult patients who need lung cancer surgery to improve the app. By combining principles of user-centered design and implementation science, our proposed research will aim to enhance the prehabilitation app for increased uptake and usage particularly among frail/pre-frail older adults.

PI_NAMEs: MADARIAGA, MARIA LUCIA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adherence;Adoption;Aging;American College of Surgeons;behavior change;Behavior Therapy;Behavioral Model;Behavioral trial;Black race;Cancer Etiology;Cancer Patient;cancer surgery;Caregivers;Caring;Cessation of life;Clinic;Clinical;clinical practice;Clinical Trials;design;Devices;Effectiveness;Elderly;Eligibility Determination;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Excision;Exercise;experience;Failure;Feedback;Focus Groups;forgetting;Foundations;Frail Elderly;frailty;Future;Goals;Habilitation;Health;Health Care Costs;Heterogeneity;Home;Hospital Costs;Hospitals;human old age (65+);implementation framework;implementation science;improved;innovation;Institutionalization;International;Intervention;Interview;Knowledge;Length of Stay;male;Malignant neoplasm of lung;Medical;Modification;mortality;Motivation;National Institute on Aging;nutrition;older adult;older patient;Oncology;Operative Surgical Procedures;Outcome;patient engagement;Patients;Perioperative;Phase;physical conditioning;Physiological;Pilot Projects;Postoperative Complications;preference;programs;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Records;Reporting;Research;Research Personnel;risk mitigation;Scientist;screening;smartphone application;Social support;Societies;Structure;surgery outcome;Text Messaging;therapy design;therapy development;Thoracic Surgical Procedures;Time;Translating;Translations;treatment effect;United States;United States National Institutes of Health;uptake;user centered design

PROJECT_TITLE: Applying User-centered Design and Implementation Science to Enhance Prehabilitation for Frail Older Adults Undergoing Lung Cancer Surgery


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Many patients with stroke, in particular minority and older patients, receive stroke care at hospitals without advanced stroke-related resources or expertise and may be less likely to receive life-saving reperfusion or high-quality stroke care as a result. A critical area for intervention is the way that patients are transferred between hospitals so that stroke patients are more equitably matched with the resources needed for their care. In this project, our goal is to understand the role that interhospital transfer processes play in contributing to disparities in access and outcomes for stroke patients, and to identify solutions to ensure better access and outcomes for stroke patients of all races and ethnicities.

PI_NAMEs: ZACHRISON, KORILYN SAUSER (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: access disparities;Acute;Acute myocardial infarction;acute stroke;Address;Affect;American;Area;Behavior;Black race;California;care outcomes;Caring;Cessation of life;Characteristics;Communities;Community Networks;Data;demographics;Destinations;Detection;detection method;deviant;disability;Disparity;disparity reduction;effective intervention;efficacious intervention;Elderly;Emergency Situation;endovascular thrombectomy;Ensure;Equity;ethnic disparity;Ethnic Origin;Funding;geographic disparity;Geography;Goals;health disparity;Health Services Accessibility;Health system;Hispanic;Hospitals;improved;improved outcome;Inequality;Inequity;Insurance;Intervention;Interview;Intravenous;Ischemic Stroke;Life;Location;Long term disability;Measures;Methodology;Methods;Minority Groups;minority patient;Modeling;mortality;Native Americans;new technology;Not Hispanic or Latino;older patient;organizational structure;Outcome;Patient Care;Patient Transfer;Patient-Focused Outcomes;Patients;Pattern;Play;Policy Maker;post stroke;primary outcome;Process;Publications;Qualitative Methods;Race;racial disparity;Racial Segregation;Reperfusion Therapy;Resources;response;Role;Science;secondary outcome;Stroke;stroke intervention;stroke outcome;stroke patient;Structural Racism;Structure;System;telestroke;thrombolysis;Time;Trauma;Underserved Population;Uninsured;United States National Institutes of Health;uptake;Variant;Work

PROJECT_TITLE: Addressing Racial/Ethnic Disparities in Stroke Care Access Using Hospital Transfer Networks

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: PROJECT NARRATIVE Pulmonary disease and recurrent exacerbations dominate the lives of patients with cystic fibrosis (CF) infected with Pseudomonas aeruginosa (Pa). The proposed K23 project will evaluate Pa antibiotic tolerance mediated by its bacteriophage, Pf, as well as the potential of Pf as a predictive biomarker for response to antibiotic therapy. This will lead to new mechanistic insights to guide therapy in treatment of Pa associated CF pulmonary disease.

PI_NAMEs: BURGENER, ELIZABETH BENDIG (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute;Address;Adult;Advisory Committees;Airway Disease;Anti-microbial susceptibility;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Aztreonam;Bacterial Chromosomes;Bacteriophages;biobank;Biological Markers;Biological Testing;Biology;Biometry;Bronchiectasis;career;career development;Caring;Chronic;chronic infection;Clinical;clinical care;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;cystic fibrosis patients;Cystic Fibrosis sputum;Data;Denmark;Development;Development Plans;Disease;Disease Management;emerging antibiotic resistance;Environment;Evolution;experience;experimental study;Foundations;Future;gene function;genome sequencing;Genomics;Growth;Human;Impairment;improved outcome;In Vitro;in vivo;Infection;Inhalation;Inovirus;insight;Longitudinal cohort;Lung;Lung Diseases;Lung infections;Measures;Mediating;Mentors;Microbial Biofilms;Microbiology;Minimum Inhibitory Concentration measurement;mucoid;Nonlytic;novel;novel therapeutics;Organism;pathogen;Patient Care;Patients;personalized approach;Phenotype;Phylogeny;Physicians;Polysaccharides;Population;predicting response;predictive marker;Prophages;prospective;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;Pulmonology;Recurrence;Research;Resistance;resistance gene;respiratory;Respiratory Disease;Respiratory Failure;Respiratory Tract Infections;response;response biomarker;Retrospective cohort;Sampling;Scientist;Serial Passage;skills;Sputum;Testing;Therapeutic;Time;Tobramycin;Tracheostomy procedure;Training;translational medicine;Translational Research;treatment strategy;Virion;Virus Integration;whole genome

PROJECT_TITLE: Bacteriophage as a predictive biomarker in chronic Pseudomonas airway disease


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Mosquito-borne alphaviruses, such as chikungunya virus, causing debilitating arthritis, and Eastern equine encephalitis virus, causing fatal encephalitis, are becoming endemic in the Americas with no available vaccines or antivirals. Using reverse genetics, cutting-edge microscopy, and molecular biology approaches, we will explore the functional role of alphavirus ion channel 6K in affecting intracellular ion homeostasis, membrane modifications, and virus budding. Identifying the host proteins in the secretory pathway modifying the Golgi facilitating virus budding will provide targets for antiviral strategies.

PI_NAMEs: JOSE, JOYCE  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 2019-nCoV;Acute;Address;Affect;Alpha Virus;Alphavirus Infections;Americas;Amiloride;Anti-viral Agents;Arthralgia;Arthritis;arthropod-borne;Biological Assay;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cell surface;Cells;chikungunya;Chikungunya fever;Chikungunya virus;Chimera organism;Communities;confocal imaging;Confocal Microscopy;CRISPR library;CRISPR/Cas technology;Defect;Disease Outbreaks;Drug Design;drug repurposing;E protein;Eastern Equine Encephalitis Virus;Encephalitis;env Gene Products;enzootic;experimental study;Family;Fluorescence-Activated Cell Sorting;Fluorescent Probes;Foundations;Geographic Locations;global health;Glycoproteins;Golgi Apparatus;Hepatitis C virus;HIV-1;Homeostasis;Human;Immunofluorescence Immunologic;In Vitro;Indian Ocean Islands;Influenza A virus;inhibitor;Integral Membrane Protein;Intracellular Membranes;Ion Channel;Ion Channel Protein;Ion Transport;Ions;Knock-out;Knowledge;knowledge of results;Life Cycle Stages;Mediating;member;Membrane;Methods;Microscopy;Mission;Modification;Molecular;Molecular Biology;Morbidity - disease rate;Morphogenesis;mortality;mosquito-borne;mutant;Mutation;National Institute of Allergy and Infectious Disease;Nature;new outbreak;new therapeutic target;novel;pathogen;Pathway interactions;Persons;Pharmaceutical Preparations;Plaque Assay;Play;Polyarthritides;premature;prevent;Process;protein transport;Proteins;proteoliposomes;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;Reporting;Reunion Island;reverse genetics;Risk;RNA Viruses;Role;Secretory Vesicles;Series;Sindbis Virus;stable cell line;Structural Protein;Structure;Surface;Testing;Therapeutic Intervention;Time;Togaviridae;tool;trafficking;United States;vaccine access;Vacuole;vector;Vesicle;Viral;Virion;Virus;Western Blotting;Work

PROJECT_TITLE: Intracellular functions and mechanisms of alphavirus ion channel 6K

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Suicidal thoughts and behaviors are increasing among children in the U.S., especially among Black youth. It is still very difficult to know who is at risk for suicide. In this study, we propose to measure experiences like loneliness, low self-worth, and hopelessness in young children to determine whether risk for suicide can be captured in early childhood, and whether protective factors such as racial socialization and identitity protect Black youth from developing suicidal thoughts.

PI_NAMEs: KEENAN, KATHRYN ELIZABETH;STEPP, STEPHANIE D (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: 11 year old;7 year old;9 year old;acceptability and feasibility;Adolescent;Age;age group;aged;analog;Behavior;Behavioral;Black American;Black race;Buffers;Cause of Death;Child;Childhood;cohort;Communities;Data;design;Development;Discrimination;early adolescence;early childhood;Early identification;emerging adult;Enrollment;ethnic identity;experience;Exposure to;Failure;falls;Family;Feeling hopeless;Feeling suicidal;girls;heart rate variability;high risk;Impulsivity;Individual Differences;Institutional Racism;Lead;Left;Loneliness;Longitudinal Studies;Measures;member;Methods;Modeling;Moods;Mothers;National Institute of Mental Health;offspring;Parents;Participant;Patient Self-Report;Phenotype;prevent;Procedures;Process;Process Measure;prospective;protective factors;Psychological Theory;Race;racial identity;racism;Reaction;Recording of previous events;recruit;Recurrence;Research;response;Risk;Risk Factors;Sampling;Self-Injurious Behavior;Social Environment;Socialization;Structural Racism;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;System;Testing;Thinking;trend;Woman;Work;Youth

PROJECT_TITLE: A Developmental Approach to Testing Suicidal Phenotypes in Early Childhood in Black Youth


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Emergency Care;Health Services;Mental Health;Prevention

ORG_CITY: BIRMINGHAM

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Delirium, an acute, fluctuating change in cognition with significant downstream consequences, is present in up to 35% of older adults in the Emergency Department (ED), but the incidence (number of patients developing delirium in the ED, versus those with delirium prior to ED visit) and time course are currently unknown. Prevention is the only effective treatment for delirium, requiring early identification of patients at-risk of developing delirium in the ED, but up to 83% of ED providers fail to recognize delirium cases, often due to lack of screening. We propose to tackle the first steps towards developing preventive and management strategies for delirium in the ED — that is, determining its incidence and time course, identifying the most relevant risk factors, and evaluating geriatric risk assessment instruments for ED delirium.

PI_NAMEs: SKAINS, RACHEL MICHELLE (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accident and Emergency department;Accreditation;Acute;acute care;Admission activity;Adult;adverse outcome;aged;Aging;aging brain;Alzheimer disease screening;Area Under Curve;Assessment tool;Award;Biometry;Caring;Cognition;Cognitive;confusion assessment method;Continuity of Patient Care;Data;Delirium;Dementia;Detection;Development;disability;Discipline of Nursing;Early identification;Early Intervention;effective therapy;Elder Abuse;Elderly;Electronic Health Record;Eligibility Determination;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency Nursing;Emergency Situation;Environment;falls;Family;frailty;Future;Geriatrics;Goals;Guidelines;Health;high risk;Hospitalization;Hospitals;Hour;human old age (65+);Impaired cognition;improved;Incidence;indexing;informant;Infrastructure;innovation;Inpatients;instrument;Intervention;Interview;K-Series Research Career Programs;Logistic Regressions;Long-Term Care for Elderly;Mentorship;Modeling;National Institute on Aging;nursing administration;Nursing Assessment;Nutritional;older adult;Outcome;Patient Admission;Patients;Performance;prevent;Prevention;Prevention strategy;Preventive;Prognosis;programs;Prospective, cohort study;Provider;Recommendation;Research;Research Assistant;Research Design;Research Personnel;Risk;Risk Assessment;Risk Factors;risk stratification;screening;Severities;skills;social;Time;tool;Triage;virtual;Visit;Work

PROJECT_TITLE: Risk Factors and Time Course of Incident Delirium Among Older Adults in the Emergency Department (ED)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Pulmonary Fibrosis;Radiation Oncology;Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Narrative: Our preliminary data suggests that radiation induced pulmonary fibrosis (RIPF) is caused by radiation-induced isoprostane signaling through the thromboxane-prostanoid receptor (TPr), and that blocking TPr with a small molecule, ifetroban, significantly reduces RIPF. In this project, we test mechanistic hypotheses, ensure that ifetroban does not diminish the effect of standard of care (immune checkpoint therapy), and still works to reduce RIPF when combined with it. We also examine human radiation oncology patients to ensure that the increased isoprostanes are also present in patients.

PI_NAMEs: FREEMAN, MICHAEL L.;WEST, JAMES D (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Ablation;Affect;Agonist;antagonist;anti-PD-1;arachidonate;Arachidonic Acids;Architecture;Attenuated;Bleomycin;Calcium;Calpain;Cancer Model;Cell Culture Techniques;cell type;Cells;checkpoint inhibition;checkpoint therapy;chemoradiation;Chest;Clinical;Clinical Research;Clinical Trials;Collagen;Complex;coronary fibrosis;Data;Deposition;Diagnostic Imaging;Disease;Dose Limiting;Ensure;epithelial injury;Event;F2-Isoprostanes;Fibroblasts;Fibrosis;Free Radicals;Gases;Generations;Genetic;Goals;Hermanski-Pudlak Syndrome;Human;idiopathic pulmonary fibrosis;ifetroban;in vivo;Infiltration;Inflammatory;inhibitor;Ionizing radiation;irradiation;Isoprostanes;Knock-out;Knowledge;Ligands;Lung;lung injury;Malignant neoplasm of lung;Mediating;Mus;Muscular Dystrophies;Mutation;Myofibroblast;Non-Small-Cell Lung Carcinoma;novel;Orphan Drugs;oxidation;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;peroxidation;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;preclinical study;prevent;programmed cell death protein 1;Proliferating;Prostaglandins;Pulmonary Fibrosis;Pulmonary Inflammation;Radiation;Radiation Fibrosis;Radiation Oncology;Radiation therapy;radiation-induced lung injury;receptor;Receptor Inhibition;Receptor Signaling;Regulation;Research;research clinical testing;response;Role;Safety;Signal Transduction;small molecule;standard of care;Structure of parenchyma of lung;Techniques;Testing;Therapeutic;Therapeutic Effect;Thromboxane A2;Thromboxanes;Time;Tissues;Toxic effect;TP53 gene;Transforming Growth Factor beta;Translations;tumor;Urine;Work

PROJECT_TITLE: The Thromboxane-Prostanoid Receptor in Radiation-Induced Pulmonary Fibrosis

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE  Arterial Spin Labeled perfusion magnetic resonance imaging (ASL-MRI) is the only non-invasive method to measure regional cerebral blood flow and has been included as a part of multi-modal MRI in several multisite longitudinal studies aimed at aging and Alzheimer's disease and related dementias (ADRD) research. ASL data can be noisy and can also vary significantly across sites. The proposed project will develop methods for automated quality evaluation and harmonization of data that will ensure maximal data retainment, optimal statistical analysis, and biomarker development.

PI_NAMEs: DOLUI, SUDIPTO  (contact);WANG, ZE

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Address;Adopted;age effect;Aging;Algorithms;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;arterial spin labeling;Automated Indexing;Biological;Biological Preservation;biomarker development;Brain;Brain imaging;cerebrovascular;Cerebrovascular Circulation;Clinical;clinical research site;combat;Computer software;Data;data harmonization;data preservation;data quality;Data Set;deep learning;deep learning algorithm;detection sensitivity;Diagnosis;Early Diagnosis;Ensure;Evaluation;Evaluation Indexes;Future;Goals;Head;Human;Image;imaging modality;Impaired cognition;improved;indexing;Infrastructure;interest;large datasets;learning network;Longitudinal Studies;Magnetic Resonance Imaging;Manuals;Maps;Mathematics;Measures;Meta-Analysis;Methods;mild cognitive impairment;Modification;Morphologic artifacts;Motion;multimodality;multiple data types;neuroimaging;Noise;novel;open source;Patients;Perfusion Weighted MRI;Phase;Physiological;preservation;Probability;Prognosis;Protocols documentation;prototype;Quality Control;Reading;Reproducibility;Research;Research Infrastructure;research study;Scanning;secondary analysis;sex;signal processing;Signal Transduction;Site;Software Tools;Source;Statistical Data Interpretation;synthetic data;Techniques;Technology;Testing;Time;tool;Training;Travel;treatment response;Validation;Vendor;Visual;Work

PROJECT_TITLE: Automated Quality Evaluation and Harmonization for Multisite ASL MRI Data


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Services;Palliative Care;Patient Safety

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Community-dwelling older adults admitted to a skilled nursing facility (SNF) following a hospitalization represent a medically complex and vulnerable population at high risk for several potentially adverse outcomes. This project uses a sample of Medicare beneficiaries aged 65 years and older discharged from a hospital to a SNF to develop and internally validate a parsimonious clinical prediction model for multiple separate outcomes (hospital re-admission, successful discharge home, prolonged SNF stay suggesting transition to long-term care, and 6-month mortality) using readily available clinical predictors that will allow SNF clinicians to directly obtain risk estimates through an easy-to-use web calculator. Prognostic information from this calculator can help frame conversations with patients and families related to management of acute and chronic conditions, treatment preferences, and future planning, and will lay the foundation for future work exploring how the implementation of this prognostic information can improve shared decision making and patient-oriented outcomes.

PI_NAMEs: DEARDORFF, WILLIAM JAMES (contact)

PROJECT_TERMS: Acute;Admission activity;Advance Care Planning;Adverse event;adverse outcome;Age;Anti-Hypertensive Agents;Award;behavior measurement;beneficiary;Calibration;career;Caring;Cessation of life;Characteristics;Chronic;Chronic Disease;Classification;Clinical;clinical care;Clinical Management;clinical practice;clinical predictive model;clinical predictors;clinically relevant;cohort;Communities;comorbidity;Complex;Data Set;Decision Making;Diabetes Mellitus;Diagnosis;Discrimination;Event;expectation;experience;falls;Family;Fee-for-Service Plans;Foundations;Funding;Future;Goals;Healthcare Systems;high risk;Home;hospice environment;hospital readmission;Hospitalization;Hospitals;human old age (65+);improved;Individual;innovation;interest;Internet;K-Series Research Career Programs;Length of Stay;Life;Long-Term Care;Measures;Medical;Medicare;Modeling;mortality;mortality risk;older adult;Outcome;outcome prediction;Palliative Care;Patient Care;Patient-Focused Outcomes;Patients;payment;Performance;Pharmaceutical Preparations;Play;predictive modeling;preference;prognostic;prognostic model;prognostic tool;randomized, clinical trials;readmission risk;Rehabilitation therapy;Research Personnel;Research Project Grants;restraint;Risk;Risk Estimate;Role;Sampling;satisfaction;shared decision making;Skilled Nursing Facilities;Techniques;Testing;Time;Update;Visit;Vulnerable Populations;Work

PROJECT_TITLE: A comprehensive prognostic model for older adults discharged to skilled nursing facilities.


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: Project Narrative Effective vaccination is key to mitigating the burden of influenza and other respiratory infections, however frailty and associated immune system aging may reduce its effectiveness among older adults at the highest risk. This work will clarify the role of frailty in outcomes following influenza vaccination among older adults. This will inform vaccine policies and future clinical trials to optimize administration of influenza vaccines.

PI_NAMEs: SELIGMAN, BENJAMIN JOSEPH (contact)

PROJECT_TERMS: Adjuvant;Adult;Affect;Age;aged;Aging;Antibody titer measurement;Cessation of life;clinical outcome assessment;Clinical Trials;cohort;Communities;comorbidity;Computerized Medical Record;Data;Data Set;Development;Dose;Effectiveness;Formulation;frailty;Future;Goals;Healthcare Systems;high risk;Hospitalization;human old age (65+);Immune response;Immune system;Impairment;indexing;Individual;Influenza;Influenza prevention;Influenza vaccination;influenza virus vaccine;Integrated Health Care Systems;Life;Link;Measures;middle age;Observational Study;older adult;Outcome;Phenotype;Physiological;Pneumococcal vaccine;Policies;Population;Population Heterogeneity;precision medicine;prevent;Preventive care;primary outcome;Recommendation;Recovery;Research;Respiratory Tract Infections;Role;seasonal influenza;Stress;stressor;Syndrome;Testing;tool;United States Department of Veterans Affairs;Use Effectiveness;Vaccination;vaccination outcome;vaccine effectiveness;Vaccines;Veterans Health Administration;Work

PROJECT_TITLE: Frailty and Influenza Vaccination Outcomes In A National Healthcare System


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Caregiving Research;Clinical Research;HIV/AIDS;Mental Health;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HUNTER COLLEGE

ORG_STATE: NY

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Older women living with HIV require adequate support from their informal care networks to meet their caregiving needs and promote mental and behavioral health as they age. Understanding the social resources that older women living with HIV have in place, including how care networks evolve over time, the factors that shape them, and how effective they are in meeting care needs, are critical areas of needed research in the HIV and aging field. Findings from this study can be used to inform social support promoting intervention development, health policy, and clinical practice to promote healthy aging among people with HIV.

PI_NAMEs: MANALEL, JASMINE A (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Active Learning;Address;Affect;Age;Age related comorbidities;Aging;Area;Basic Science;Behavioral;behavioral health;Black race;care burden;career development;Caregivers;caregiving;Caring;Classification;clinical practice;Community Developments;community partnership;Complex;Data;Data Reporting;Data Sources;depressive symptoms;Development;Development Plans;Dimensions;Effectiveness;Evolution;experience;Family;Friends;Future;Health;Health behavior;Health Policy;healthy aging;HIV;HIV Seropositivity;HIV/AIDS;Individual;informal care;informal caregiving;Intervention;Interview;Knowledge;Latina;Life Cycle Stages;life history;Link;Literature;Loneliness;Managed Care;marginalization;Measures;Medicaid;medication compliance;meetings;men;Mental Health;Mental health promotion;Mentors;Methodology;Methods;Modeling;multiple chronic conditions;New York City;novel;older adult;Older Population;older women;Participant;Patient Self-Report;Pattern;Personal Satisfaction;Persons;Population;preference;psychosocial;Public Health;public health relevance;recruit;Reduce health disparities;Reporting;Research;Research Methodology;Research Project Grants;research study;Resources;Role;Sampling;Shapes;skills;social;Social Network;Social support;sociocultural determinant;Source;Structure;Support System;Surveys;Targeted Research;Testing;therapy development;Time;Training;translational impact;Translational Research;United States;United States National Institutes of Health;Woman;women of color

PROJECT_TITLE: Caregiving networks of older women living with HIV.

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Gene editing utilizes a collection of molecular technologies to change the genetic sequences in cells or organisms. Although extremely useful, gene editing technologies have several limitations, including difficulties controlling the number and location of insertions produced during transgenesis, and limitations in the scale and throughput of genome editing in lab animals such as zebrafish. This proposal seeks to address these limitations by developing several new gene editing technologies based on DNA integrases and CRISPR nucleases.

PI_NAMEs: PETERSON, RANDALL T (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Animals;Area;Bar Codes;Biomedical Research;Biomedical Technology;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;combinatorial;Communities;CRISPR screen;CRISPR/Cas technology;Development;disease model;DNA;droplet sequencing;Embryo;Engineering;Financial Support;Fishes;Funding;Future;gene editing technology;gene function;Gene Transfer Techniques;gene-editing approach;Genes;Genetic Diseases;Genome;genome editing;genomic locus;Genomics;high throughput screening;high throughput technology;innovation;Integrase;interest;Location;Locomotion;metabolomics;Methods;Microfluidics;Modification;Molecular;molecular phenotype;Monitor;Morphology;mutant;Mutation;nanolitre;Needles;new technology;nuclease;Organism;Phenotype;Plasmids;prime editing;promoter;Proteins;recombinase;Recovery;Regulatory Element;Research Personnel;reverse genetics;screening;single-cell RNA sequencing;Site;small molecule;Specific qualifier value;Specificity;System;Technology;technology development;technology platform;tool;transcription activator-like effector nucleases;Transgenic Organisms;Visual;Zebrafish

PROJECT_TITLE: ADVANCING GENE-EDITING NUCLEASES FOR DIVERSE ZEBRAFISH APPLICATIONS

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_DEPT: PATHOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Prevalence of cardiac transplantation continues to increase around the globe with little improvement to patient morbidity and late stage allograft rejection. This proposal aims to understand the role of the conventional dendritic cell 1 (cDC1) subset in prolonging cardiac allograft survival and the influence of donor antigen exposure on cDC1 function. Specifically, how cDC1 signaling may facilitate a regulatory and hypoactive T cell response to improve graft survival and how such mechanisms can be targeted to decrease morbidity and improve patient care.

PI_NAMEs: SCHROTH, SAMANTHA LEIGH (contact)

PROJECT_TERMS: Acute;adaptive immune response;Adult;Affect;Alloantigen;allograft rejection;Allograft Tolerance;Allografting;Anti-Inflammatory Agents;Antibodies;Antigen-Presenting Cells;Antigens;Apoptotic;arm;Biological Response Modifiers;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Therapy;Cells;central tolerance;Childhood;Chimerism;Chronic;Coupled;cytokine;Data;Dendritic Cells;Development;Diabetes Mellitus;Disparate;Echocardiography;Evaluation;experience;Exposure to;Flow Cytometry;Genetic Transcription;graft failure;Graft Rejection;Graft Survival;Growth;heart allograft;Heart failure;Heart Transplantation;Histology;Immune;Immune response;Immune system;Immune Tolerance;Immunologics;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;infancy;Inflammatory;inflammatory milieu;Infusion procedures;Instruction;Interleukin-6;Investigation;kidney dysfunction;Malignant Neoplasms;Manuals;Mediating;Mediator;Metabolic;Methods;Mitochondria;Modeling;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;mouse model;Mus;nonhuman primate;novel;Operative Surgical Procedures;Organ Transplantation;Palpation;Pathology;Pathway interactions;Patient Care;Patients;Peripheral;peripheral tolerance;Pharmaceutical Preparations;Physiological;Play;Population;post-transplant;Prevalence;prevent;Process;programmed cell death ligand 1;programs;Reporting;Research;response;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Solid;Splenocyte;standard of care;Surface;T cell response;T-Cell Proliferation;T-Lymphocyte;Techniques;Testing;TNF gene;TNFSF5 gene;transcriptional reprogramming;transcriptomics;transplant model;Transplant Recipients;Transplantation;Up-Regulation;uptake;Validation;Vascular Diseases;Work

PROJECT_TITLE: Requirements and mechanisms of alloantigen-induced cardiac allograft survival by cDC1s


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Microbiome;Women's Health Research

ORG_CITY: MELBOURNE

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: MURDOCH CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE One million individuals in the United States identify as transgender (0.39% of population), of which 90% are either on gender-affirming hormone therapy (GAHT) or considering starting GAHT. In this project we will apply a systems immunology approach to explore how GAHT affects immune function at the cellular, metabolic, and epigenetic level. Considering the high rates of HIV infection in transgender women in the United States, understanding how GAHT influences immune function and susceptibility to infection is relevant to public health, while in the longer-term potential immune signalling pathways can be therapeutically targeted to improve immune function during GAHT.

PI_NAMEs: NOVAKOVIC, BORIS  (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Address;Affect;Antibodies;ATAC-seq;B-Lymphocytes;Biological Assay;Birth;Blood;Blood Cells;Blood specimen;CD28 gene;CD3 Antigens;Cell Physiology;cell type;Cells;Cheek structure;Cholesterol;Chromatin;Chronic;circulating biomarkers;Circulation;cis-female;cohort;Cohort Studies;Collection;cytokine;DNA Methylation;Environment;Epigenetic Process;epigenomics;Epithelial Cells;Estradiol;Exposure to;fecal microbiota;Feces;Feminization;fighting;Flow Cytometry;Fumarates;gender affirming hormone therapy;Gender Identity;Gene Expression;genomic locus;Gonadal Steroid Hormones;Hair;high dimensionality;histone modification;Histones;HIV;HIV Infections;Hydrocortisone;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;Immunology;Immunophenotyping;immunoregulation;improved;In Vitro;in vitro Model;Individual;Infection;Inflammation;innate immune function;Knowledge;Ligands;Link;Longitudinal cohort;Maps;Masculine;Measures;Metabolic;Microbe;microbial;microbiome;Modeling;Molecular;Molecular Biology;Molecular Profiling;monocyte;Natural Killer Cells;Nuclear Receptors;Pathway interactions;Peripheral;peripheral blood;Peripheral Blood Mononuclear Cell;Phenotype;Plasma;Population;predicting response;Predisposition;Pregnancy;Prevalence;Puberty;Public Health;receptor;recruit;reproductive tract;response;Risk;Role;Saliva;sample collection;sex assigned;Sex Differences;sexual dimorphism;Sexual Transmission;Sexually Transmitted Diseases;Signal Pathway;single cell ATAC-seq;single-cell RNA sequencing;Stress;System;T cell response;T-Cell Proliferation;T-Lymphocyte;targeted treatment;Techniques;Testosterone;Therapeutic;Therapeutic Intervention;therapeutic target;Training;transcription factor;transcriptome sequencing;transgender;transgender men;transgender women;United States;Vaccines;vaginal microbiota;Viral;Virus;Virus Diseases

PROJECT_TITLE: Understanding the effects of Gender Affirming Hormone Therapy (GAHT) on immune function using a systems immunology approach

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: The overall purpose of the Texas RCMAR is to enhance the diversity of the aging research work force by mentoring scientists from underrepresented populations to help them develop sustained careers in behavioral, social, economic, and medical research with a focus on minority populations, primarily Hispanics/Latinos in Texas, the Southwestern United States, and Mexico, as well as health disparities in general. Through our Leadership and Administrative Core (LAC), Analysis Core (AnC) and Research Education Component (REC), we will continue to leverage our national and international network of colleagues to develop infrastructure to promote advances in these areas and to increase the number of investigators in the area of health and aging of minority populations and health disparities. Our success in mentoring RCMAR Scientists into independent researchers will expand, with the addition of the University of Texas at San Antonio as a new partner, joining the University of Texas Medical Branch and the University of Texas at Austin in support of our theme of Migration, Aging, and Health.

PI_NAMEs: MARKIDES, KYRIAKOS S (contact)

PROJECT_TERMS: advanced analytics;Aging;analytical method;Area;Behavioral;Behavioral Sciences;career;career development;Collaborations;Data;Development Plans;Economics;education research;Educational Activities;Elderly;Ensure;Epidemiology;epidemiology study;equity, diversity, and inclusion;Ethnic Population;experience;Faculty;Funding;Goals;Health;Health Disparities Research;health disparity;Health Status;Hispanic;Hispanic Populations;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;Instruction;interest;International;Latino Population;Leadership;Longitudinal Studies;Measurement;Measures;Medical;Medical Research;Mentored Clinical Scientist Development Program;Mentors;Methodology;Mexican;Mexico;migration;Minority;Minority Groups;minority health disparity;Minority Health Research;Mission;Monitor;multidisciplinary;older adult;organizational structure;Pilot Projects;Population;population based;Population Heterogeneity;Procedures;Process;program dissemination;Program Evaluation;programs;Puerto Rican;Qualifying;racial population;recruit;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;Resources;Science;Scientist;social;social health determinants;Social Sciences;Source;Southwestern United States;Structure;success;Texas;Training;Training Programs;Underrepresented Populations;Universities;Update;Work

PROJECT_TITLE: The Texas Resource Center on Minority Aging Research (RCMAR)


NIH_SPENDING_CATS: Aging;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Advocate;Aging;Area;Behavioral;career;Communication;Databases;Development;Economics;education research;Educational Activities;Educational workshop;Ensure;equity, diversity, and inclusion;Ethics;Evaluation;Faculty;faculty mentor;Funding;Grant;Health;health disparity;Hispanic Populations;improved;Infrastructure;innovation;Institution;International;Knowledge;Latino Population;Lead;Leadership;lectures;Longevity;Medical Research;member;Mentors;Mexico;migration;Minority;Minority Groups;minority health disparity;minority investigator;Modeling;older adult;operation;Outcome;Parents;peer coaching;Pilot Projects;Population Sciences;Procedures;Process;programs;recruit;Reporting;Research;Research Activity;Research Personnel;Resources;responsible research conduct;Science;Scientist;skills;social;Source;Southwestern United States;Teacher Professional Development;Texas;Training;Underrepresented Populations;Universities;Work;Writing


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: KUO, YONG-FANG  (contact)

PROJECT_TERMS: advanced analytics;Aging;analytical method;Behavioral;behavioral and social science;Collaborations;Communities;Consultations;Data;Data Analyses;data management;Data Set;Dedications;Demographer;design;Disablement;Discipline;Disparity population;Economics;education research;Educational workshop;Elderly;Epidemiologist;epidemiology study;Faculty;Fostering;frailty;Generations;Geriatrics;Gerontology;Health;Health Disparities Research;health disparity;health inequalities;Healthcare;Hispanic;Hispanic Populations;Home;Human Resources;Individual;Influentials;Infrastructure;innovation;Institution;Instruction;Knowledge;longitudinal analysis;longitudinal dataset;Longitudinal Studies;Machine Learning;Measurement;Medical;medical specialties;Mentors;Methodology;Methods;Mexican;Mexican Americans;Mexico;migration;Minority;Minority Groups;Minority Health Research;Modeling;Monitor;older adult;Online Systems;Outcomes Research;Pilot Projects;Population;population health;Productivity;psychologic;Publishing;Recording of previous events;Rehabilitation therapy;Research;Research Design;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Scientist;Series;Services;social;Social Behavior;social disparities;social health determinants;social science research;Social Sciences;sociologist;Source;Southwestern United States;Statistical Data Interpretation;Surveys;Techniques;Texas;Training;Universities;Update


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Rehabilitation;Stroke

ORG_CITY: SANTA BARBARA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative More than one million Americans present with foot drop after stroke. As our aging population grows in the United States and across the world, incidence of stroke will grow as age is a key risk factor, thus there will be a need for low-cost, easy-to-use, and scalable solutions to administer proper therapy to promote recovery. This study will evaluate a Variable Friction shoe (VF shoe), a new low-cost medical device, to offer therapy for foot drop in an at-home setting.

PI_NAMEs: HAWKES, ELLIOT WRIGHT (contact)

PROGRAM_OFFICER_NAME: NURMINSKAYA, MARIA

PROJECT_TERMS: actigraphy;Address;Adoption;Affect;Age;aging population;American;Ankle;ankle joint;arm;Auditory;Biofeedback;Characteristics;Chronic;chronic stroke;clinical efficacy;Clinical Trials;cost;Coupled;Custom;Data;Devices;Effectiveness;Equilibrium;Exhibits;fear of falling;Feedback;Floor;foot;Foot-drop;Foundations;Friction;functional electrical stimulation;Future;Gait;Gait abnormality;Gait speed;hazard;Hip region structure;Home;Home Ranges;improved;Individual;Joints;kinematics;Manuals;Measurement;Measures;Mechanics;Medical Care Costs;Medical Device;Minor;Modeling;Monitor;Motion;Movement;Muscle;Musculoskeletal;Nature;neglect;neuromuscular system;Orthotic Devices;Participant;Patients;Performance;peroneal nerve;Persons;Phase;Positioning Attribute;post stroke;prevent;primary outcome;Recovery;Rehabilitation therapy;responders and non-responders;Risk;Risk Factors;Series;Shoes;sound;stem;Stress;Stroke;stroke incidence;stroke survivor;Structure;Surface;Testing;Therapeutic;Therapeutic Effect;therapy outcome;Toes;tool;Torque;Training;United States;Volition;Walking;walking speed;Weight;Work

PROJECT_TITLE: Characterization and clinical trial of a Variable Friction Shoe, a new paradigm of reduced-constraint locomotor therapy for people exhibiting foot drop due to stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: WONG, REBECA  (contact)

PROJECT_TERMS: Abbreviations;Achievement;Address;Aging;Americas;Applications Grants;Association of American Medical Colleges;Behavioral;behavioral and social science;Benchmarking;Black race;cancer prevention;career;career development;caregiving;Cervical Cancer Screening;Clinical and Translational Science Awards;cognitive testing;cohort;Collaborations;Communities;community based research;Dementia;design;Development;Development Plans;Discipline;Education;education research;experience;Faculty;faculty mentor;Funding;Group Meetings;Health;Health Disparities Research;health disparity;health organization;Health Sciences;Hispanic;improved;Individual;Institution;instrument;Interdisciplinary Study;interest;International;K-Series Research Career Programs;Lead;Leadership;Learning;Medical;meetings;member;Mentored Clinical Scientist Development Program;Mentors;migration;Minority;Minority Health Research;Mission;Monitor;multidisciplinary;next generation;Outcome;Pan American Health Organization;Pilot Projects;population health;Population Study;Preparation;Prevention Research;Process;Productivity;professor;Program Effectiveness;programs;Protocols documentation;Public Health Schools;Qualifying;recruit;Research;research faculty;Research Personnel;Resources;responsible research conduct;Retirement;Role;Science;Scientist;screening;senior faculty;skills;social;Stress;Structure;success;Surveys;symposium;System;Texas;timeline;Training;Translational Research;trend;Underrepresented Populations;Universities;Work;World Health Organization


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Aortic Stenosis (AS) is a significant disease of the aortic valve of the heart, which is chronic, progressive, and has a 2-year survival rate of 50% in symptomatic patients who are untreated. In as many as 30-40% of subjects with low gradient but potentially severe AS current diagnostic methods are discordant and inconclusive. The proposal will develop new MRI methods for improved stratification of these subjects.

PI_NAMEs: AMINI, AMIR A (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;4D MRI;Adopted;adverse outcome;Affect;aging population;anatomic imaging;Anatomy;Aortic Diseases;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Area;Breathing;Catheterization;Cessation of life;Chest;Chronic;Classification;Clinical;Correlation Studies;data space;deep learning;Diagnostic;Diagnostic Procedure;Dobutamine;Dobutamine Stress Echocardiography;Doppler Echocardiography;Drops;Echocardiography;Enrollment;Equation;Goals;Heart;Heart failure;Heart Valve Diseases;hemodynamics;human subject;Image;imaging modality;improved;Learning;Left Ventricular Ejection Fraction;Liquid substance;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;Modality;Morphologic artifacts;Nature;Noise;Operative Surgical Procedures;Patients;pressure;Protocols documentation;respiratory;Rest;Risk;Safety;Scanning;Severities;Severity of illness;simulation;Stratification;Stress;Subgroup;Survival Rate;Symptoms;Syncope;Therapeutic Embolization;tomography;training data;ultrasound;Work

PROJECT_TITLE: 4D Flow MRI in Assessment of True Severe Low-Gradient Aortic Stenosis

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Diabetes;Genetics

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Diabetes is a chronic disease that results from poor function of insulin-producing beta cells within the pancreas. The goal of our study is to understand how strengthening the health of beta cell mitochondria, the power plants of the cell, is important for the prevention of diabetes. Our studies will determine the relevance of supporting the health of mitochondria to ensure that beta cells can generate the energy needed to make insulin and control blood sugar.

PI_NAMEs: KAUFMAN, BRETT A;RUTTER, GUY ALLEN;SOLEIMANPOUR, SCOTT  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Affect;Agonist;Anabolism;Area;Beta Cell;Blood Glucose;blood glucose regulation;Cell Physiology;Cells;Cellular biology;Characteristics;Chronic Disease;Data;Defect;Deposition;Diabetes Mellitus;diabetes pathogenesis;Diabetes prevention;Diabetic mouse;DNA copy number;Dynamin;Equilibrium;Evaluation;Exhibits;Exposure to;Failure;Functional disorder;Gene Dosage;Glucose Intolerance;Goals;Guanosine Triphosphate Phosphohydrolases;Health;high resolution imaging;Homeostasis;Human;imaging approach;Impairment;improved;in vivo;Induced Mutation;insight;Insulin;insulin secretion;islet;islet amyloid polypeptide;Link;Maintenance;Mediating;Membrane;Metabolic;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;Mitochondrial RNA;Modeling;mouse model;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;optogenetics;overexpression;Pancreas;Pathogenesis;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Peptide Hydrolases;Peripheral;pharmacologic;Physiological;Ploidies;posttranscriptional;Power Plants;Prediabetes syndrome;prevent;Production;Publishing;Regulation;Reporting;Respiration;restoration;Risk;Role;Signal Transduction;Stress;Structural defect;Structure;superresolution imaging;Testing;Tissues;Xenograft Model

PROJECT_TITLE: Control of insulin secretion by mitochondrial fusion

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Periodontitis affects nearly half of the US adults and is associated with poor quality of life and increased healthcare costs. Periodontitis can be prevented if the high-risk patients are identified before the disease initiation and progression. A prediction model that identifies early bone loss patterns using advanced image processing and informatics methods proposed in this study may identify high-risk patients before the disease initiation to provide preventive management.

PI_NAMEs: PATEL, JAY  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: accurate diagnosis;Adult;Affect;Algorithms;alveolar bone;Alveolar Bone Loss;American;Area Under Curve;Artificial Intelligence;Assessment tool;Biological;bone;Bone Density;bone loss;career development;Censuses;Clinical;Clinical Decision Support Systems;clinical practice;community research;Computer software;Computer Vision Systems;Data;data quality;Data Set;Databases;Decision Making;deep learning algorithm;deep learning model;demographics;Dental;Dental Clinics;Dental Informatics;Dental Records;Dental Schools;Dentistry;Dentists;design;Detection;Deterioration;Development Plans;Diagnosis;Diagnostic;diagnostic accuracy;disability;Disease;disease diagnosis;disorder prevention;Documentation;Early Diagnosis;Early identification;Electronics;empowerment;Ensure;Evidence based practice;Exposure to;Eye;Frequencies;Funding;Goals;Habits;Health;Health Care Costs;Health Status;high risk;Human;Image;Image Enhancement;image processing;imaging informatics;improved;lectures;Lesion;Literature;Manuals;Measurement;Measures;Medical Records;Medicine;Mentors;Methods;Minerals;Modeling;National Institute of Dental and Craniofacial Research;Natural Language Processing;Noise;novel;novel strategies;Oral;Oral health;Pain;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Performance;periapical;Periodontal Diseases;Periodontitis;predictive modeling;Prevalence;prevent;Prevention;Prevention strategy;Preventive;Preventive care;Privatization;Process;Prognosis;programs;protective factors;prototype;Psyche structure;psychologic;Quality of life;radiological imaging;Radiology Specialty;Reporting;Research;Research Personnel;Risk;Risk Assessment;Scientist;skills;social;social health determinants;Systemic disease;Technology;Testing;Therapeutic;Time;tool;Tooth Diseases;Tooth Loss;Training;training data;Translating;Translations;treatment planning;Visit

PROJECT_TITLE: Automatic identification of early bone loss patterns from radiographs invisible to human eyes for early periodontal disease diagnosis and prevention


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Current influenza viruses do not provide broadly protective immunity due to the immunodominance of humoral immunity against evolving epitopes of the hemagglutinin head domain rather than against the conserved stalk domain. In this study, we will rationally design and test a vaccine that shifts immunodominance of humoral immunity towards the stalk domain by increasing the diversity of head epitopes, which will allow stalk-specific B cells to more readily acquire antigen and be selected into the long-lived memory B cell pool. Using multiple models of preexisting immunity, our study will reveal that increasing head epitope diversity augments broadly protective humoral immunity.

PI_NAMEs: GUTHMILLER, JENNA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Adult;Affinity;anti-influenza;Antibodies;Antibody Binding Sites;Antibody Response;Antigen Presentation;Antigenic Variation;Antigens;Avidity;B-Cell Antigen Receptor;B-Lymphocytes;Binding;Binding Sites;CD4 Positive T Lymphocytes;combinatorial;Coronavirus;crosslink;design;Ebola virus;emerging pathogen;Epitopes;experimental study;Exposure to;Flavivirus;Frequencies;Generations;Hantavirus;Head;Health;Helper-Inducer T-Lymphocyte;Hemagglutinin;HIV;Human;Humoral Immunities;Immune;Immune system;Immunity;Immunize;Immunologics;improved;Individual;Infant;Influenza A Virus, H1N1 Subtype;influenza virus vaccine;influenzavirus;Knowledge;Laboratories;Libraries;lymph nodes;Memory B-Lymphocyte;memory recall;Modeling;Monoclonal Antibodies;monoclonal antibody production;Mus;Mutagenesis;Mutate;Mutation;neoantigens;novel;Organoids;pandemic disease;Parasites;pathogen;Plasmodium;Play;Population;Postdoctoral Fellow;Pre-Clinical Model;prevent;rational design;Recording of previous events;recruit;Research;response;Role;seasonal influenza;Seasons;Serum;Shapes;Site;Specificity;T cell response;Testing;Titrations;translational immunology;Vaccination;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine efficacy;vaccine evaluation;Vaccines;Variant;Virus;Work;Yeasts

PROJECT_TITLE: Shifting immunodominance of humoral immunity against influenza viruses


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

PHR: PROJECT NARRATIVE: OVERALL The purpose of the MCUAAAR is to recruit, mentor, and develop the next generation of diverse NIH researchers engaged in research on the science and amelioration of health inequities and disparities among African American older adult populations, and to engage the community of African American older adults in new ways to promote research participation.

PI_NAMEs: LICHTENBERG, PETER A.;TAYLOR, ROBERT JOSEPH (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Adult;African American;African American population;Aging;behavioral and social science;Black race;college;Communities;community advisory board;community based research;community engagement;Community Health Education;community involvement;Development;Development Plans;education research;Evaluation;experience;Faculty;Foundations;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;health inequalities;improved;Individual;Knowledge;Leadership;lens;Life Cycle Stages;Link;Manuscripts;Measurement;meetings;Mentors;Methods;Michigan;Mission;Modeling;next generation;older adult;Outcome;Participant;Population;Preparation;Principal Investigator;programs;Publications;Publishing;recruit;Reduce health disparities;Registries;Research;research faculty;Research Methodology;Research Personnel;Role;Science;Scientist;Series;Stress and Coping;Structure;success;summer program;Training;Training Activity;Translational Research;Twin Multiple Birth;United States National Institutes of Health;Universities;virtual;Writing

PROJECT_TITLE: Michigan Center for Urban African American Aging Research


NIH_SPENDING_CATS: Aging;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: TAYLOR, ROBERT JOSEPH (contact)

PROJECT_TERMS: Address;African American;African American population;Aging;Alzheimer's Disease;American;Arabs;Asian;Attention;Behavioral Sciences;Black American;Capsicum;Cessation of life;Collaborations;Communities;community advisory board;community engagement;Community Outreach;community partners;contaminated water;Country;Educational workshop;Emergency Situation;Ensure;Environmental Health;equity, diversity, and inclusion;ethnic minority;Ethnic Origin;Evaluation;Event;experience;Faculty;faculty community;follow-up;Funding;Gerontology;Goals;Grant;Group Meetings;Health;Historically Black Colleges and Universities;Individual;Institution;Lead;Leadership;Life Cycle Stages;meetings;member;Mentors;Methods;Michigan;Modeling;next generation;Outcome;Participant;Performance;Principal Investigator;Process;Productivity;programs;racial diversity;Recording of previous events;recruit;Registries;Research;Research Personnel;Role;Scientist;Site;skills;social;Social Sciences;Stress and Coping;Structure;success;summer program;symposium;Teacher Professional Development;Technology;Teleconferences;Time;Training;United States;United States National Institutes of Health;Universities;Videoconferencing;women faculty;Work

PROJECT_TITLE: Michigan Center for Urban African American Aging Research - Leadership and Administrative Core (LAC)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: MEZUK, BRIANA  (contact)

PROJECT_TERMS: Address;African American;African American population;Aging;analytical method;analytical tool;Applications Grants;Behavioral;Behavioral Sciences;Biological;biopsychosocial;case-based;Code;Collaborations;Communication;Communities;Consultations;coping;Data;Data Analyses;Data Collection;data resource;data sharing;Decision Making;design;Documentation;Educational workshop;Ensure;Ethics;experience;Exposure to;Faculty;Goals;Health;health determinants;health inequalities;human centered design;innovation;insight;Institution;inter-institutional;interest;Knowledge;Lead;Leadership;Life Cycle Stages;Machine Learning;Manuscripts;Measurement;meetings;Mentors;Mentorship;Methodology;Methods;Michigan;Minority;Modeling;novel;novel strategies;older adult;open data;Outcome;Participant;Peer Review;Personal Satisfaction;Phase;Pilot Projects;Procedures;Process;Protocols documentation;psychologic;Publications;Recording of previous events;Reproducibility;Research;Research Assistant;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;research to practice;Resources;Science;Scientist;skills;social;Social Sciences;stakeholder perspectives;Statistical Data Interpretation;Stress;Structure;symposium;Techniques;tool;Training;United States National Institutes of Health;Universities;videoconference;webinar;Work;working group

PROJECT_TITLE: Michigan Center for Urban African American Aging Research - Analysis Core (AnC)


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WOODWARD, AMANDA TOLER (contact)

PROJECT_TERMS: Academia;African American;African American population;Aging;Area;Behavioral;behavioral and social science;Behavioral Sciences;biopsychosocial;Black American;Black race;college;Communities;community partners;course development;Development;Development Plans;doctoral student;Economics;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Effectiveness;Elderly;Ethics;ethnic minority;Ethnic Origin;Evaluation;Faculty;follow-up;fundamental research;Funding;graduate school;Grant;Health;health disparity;Historically Black Colleges and Universities;Individual;K-Series Research Career Programs;Latino Population;Life Cycle Stages;Literature;Manuscripts;member;Mental Health;Mentors;Methodology;Methods;Michigan;Minority;minority investigator;Native Americans;next generation;Occupations;older adult;Outcome;outreach;Peer Review;Personal Satisfaction;physical conditioning;Pilot Projects;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Publications;Publishing;Race;racial minority;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;research study;Role;Schools;Science;Scientist;Series;social;Social Sciences;Social Workers;sociologist;Stress and Coping;Structure;success;Tennessee;tenure track;Training;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Michigan Center for Urban African American Aging Research - RESEARCH CORE (REC)


PI_NAMEs: MITCHELL, JAYMIA ANN (contact)

PROJECT_TERMS: African American;African American population;Aging;Applications Grants;Black race;Cessation of life;Characteristics;Communities;community advisory board;community based practice;community based research;community engaged research;community engagement;community organizations;Community Outreach;COVID-19;COVID-19 pandemic;Dementia;Educational workshop;Elderly;Enrollment;experience;Faculty;Fright;Gerontology;Grant;Health;Impaired cognition;innovation;interest;Investigation;Leadership;Logic;Manuscripts;member;Mental Health;Methods;Michigan;Modeling;Not Hispanic or Latino;older adult;Outcome;pandemic disease;Participant;Peer Review;Population;Prevalence;Program Evaluation;programs;racial population;recruit;recruitment science;Registries;Reporting;Research;Research Design;research in practice;Research Personnel;Research Project Grants;Scholarship;social health determinants;symposium;Training;United States National Institutes of Health;Universities;Visit;web site;Work

PROJECT_TITLE: Michigan Center for Urban African American Aging Research - COMMUNITY LIAISON AND RECRUITMENT CORE (CLRC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung

PHR: NARRATIVE Effective preventions and therapeutics for Staphylococcus aureus infection remain limited to antibiotics, which are challenged by increasing bacterial resistance. It is vitally important to determine the infection specific-roles of bacterial products as they contribute to pathogenesis. This project focuses on a newly identified S. aureus factor that is required for lung infection and will determine its mechanism of action, in order to elucidate therapeutic targeting potential.

PI_NAMEs: ALCORN, JOHN F (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Address;Adherence;Adhesions;Alveolar Macrophages;Animal Model;Antibiotic Therapy;Antibiotics;Antigen Presentation;Attenuated;attenuation;Bacteria;Bacterial Adhesion;Bacterial Attachment Site;bacterial resistance;Binding;Cell Culture Techniques;Cell Death;Cell Wall;Cell-Matrix Junction;Cells;Clinical;community acquired pneumonia;COVID-19 pandemic;cytokine;Data;Enzymes;Epithelial Attachment;Epithelial Cells;Epithelium;experimental study;Extracellular Matrix Proteins;Future;Genome;Growth;Human;human model;humanized mouse;Imaging Techniques;Immune;Immune system;Immunity;immunoregulation;In Vitro;in vitro Assay;in vivo;Individual;Infection;Inflammasome;Inflammation;Inflammatory;Influenza;influenza infection;influenzavirus;Injury;Interleukin-1 beta;Laboratories;Lung;Lung infections;lung injury;Macrophage;Mediating;member;Membrane Proteins;methicillin resistant Staphylococcus aureus;Monoclonal Antibodies;mortality;Mus;mutant;Mutation;new therapeutic target;novel;Organoids;Pathogenesis;Pathway interactions;Phagocytes;Phagolysosome;Pneumonia;pre-clinical;Predisposition;Prevention;Production;protein expression;Protein Family;Proteins;Publishing;Pulmonary Inflammation;recruit;Regulation;Research;Role;Signal Transduction;sortase;Stains;Staphylococcus aureus;Staphylococcus aureus infection;superinfection;System;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;therapeutic target;therapy design;tool;uptake;Vaccine Design;Vaccines;Viral;Virulence;Virulence Factors;Virus Diseases;Work

PROJECT_TITLE: The Role of Staphylococcus aureus SasD in Lung

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RCCS-Q(03)]