NIH_SPENDING_CATS: Asthma;Genetics;Immunotherapy;Lung

PHR: PROJECT NARRATIVE: CD4+ T helper 2 (TH2) cells normally function against parasitic diseases but can largely contribute to the development of asthma, a hyperinflammatory airway disease with increasing prevalence worldwide. Gaps in knowledge exist regarding the mechanisms governing TH2 differentiation and effector function. The work described in this proposal seeks to provide novel mechanistic insight into the molecular regulation of TH2 cells, with an overarching goal to identify molecular targets that can be leveraged for therapeutic benefit.

PI_NAMEs: TUAZON, JASMINE ASHLEY (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adoptive Transfer;Adult asthma;Airway Disease;Allergic;Anti-Inflammatory Agents;Apoptosis;Asthma;asthma model;ATAC-seq;Autoimmune Diseases;Binding;career;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cells;Cellular Immunology;Childhood;ChIP-seq;Chromatin;college;Communication;Complex;Critical Care;cytokine;Cytokine Receptors;Cytokine Signaling;Data;Development;Disease;Doctor of Philosophy;Environment;Epigenetic Process;extracellular;Extrinsic asthma;Fellowship;Flow Cytometry;FOXP3 gene;Functional disorder;GATA3 gene;Gene Expression;Generations;Genes;Genetic Transcription;genomic locus;Goals;Health;Helper-Inducer T-Lymphocyte;Human;Hypersensitivity;IL-4R alpha;Immune response;Immunity;Immunology;Impairment;improved outcome;In Vitro;in vivo;Infection;Inflammatory;insight;Interleukin-13;Interleukin-2;Interleukin-4;Interleukin-5;Jasminum;Knowledge;Laboratories;Location;Lung;Mediating;Medicine;Mentors;microbial;mid-career faculty;Molecular;Molecular Immunology;Molecular Target;mouse model;Mus;mutant;novel;Ohio;Outcome;overexpression;Parasites;Parasitic Diseases;pathogen;Pathogenesis;Phosphorylation;Physicians;Play;polarized cell;Population;Prevalence;programs;Proliferating;Property;protein expression;Publishing;Pyroglyphidae;Reaction;receptor;Receptor Activation;Regulation;Regulatory Element;Regulatory T-Lymphocyte;Research;response;retroviral transduction;RNA;Role;Scientist;Signal Induction;Signal Transduction;Sleep;STAT protein;Stat2 protein;stem;T cell differentiation;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;Technical Expertise;Techniques;Testing;Therapeutic;Training;transcription factor;Transgenic Organisms;Tyrosine Phosphorylation;Universities;Work;Writing;Zinc Fingers

PROJECT_TITLE: The Ikaros zinc finger transcription factor Eos as a candidate regulator of TH2 differentiation and effector function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE In its most severe form, sepsis causes hypotension that can lead to organ failure and death, a process that is often treated with vasopressor medications that raise blood pressure and increase blood flow to vital organs. This proposal will assess current practices for delivering vasopressors in sepsis and the association of these practices with patient outcomes and complications, and will identify factors that influence provider decisions about how to administer vasopressors. The ultimate goal of this proposal is to inform future clinical trials to optimize vasopressor delivery and improve sepsis outcomes.

PI_NAMEs: MUNROE, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Academic support;Address;Affect;Area;Award;Blood flow;Blood Pressure;Blood Vessels;care providers;career;career development;Case Study;Catheters;Cessation of life;Chicago;Clinical;Clinical Trials;Complication;Critical Care;Data;Data Set;Decision Making;design;Development;Development Plans;Dose;Equilibrium;Equipoise;evidence base;experience;Fellowship;Funding;Future;Goals;Grant;Health Care Research;Hospitalization;Hospitals;Hypotension;Iatrogenesis;Impairment;implementation barriers;improved;Infection;innovation;interest;Internal Medicine;IV Fluid;K-Series Research Career Programs;Knowledge;Liquid substance;Lung;Medicine;Mentors;Methods;Michigan;Modeling;Monitor;Morbidity - disease rate;mortality;multilevel analysis;National Heart, Lung, and Blood Institute;novel;Organ;Organ failure;Outcome;Patient-Focused Outcomes;Patients;Pattern;Peripheral;Peripheral Resistance;Pharmaceutical Preparations;Physicians;pilot trial;Policies;Process;Protocols documentation;Provider;Publications;Publishing;Randomized;Recommendation;Recovery;recruit;Registries;Research;Residencies;Residual state;Resuscitation;Risk Adjustment;Route;routine care;Safety;safety and feasibility;Scientist;Sepsis;Septic Shock;Severity of illness;Shock;skills;Societies;Statistical Data Interpretation;Statistical Methods;statistics;success;Surveys;Survivors;symposium;Testing;Thrombosis;Time;tissue injury;Training;Universities;Variant;Vasoconstrictor Agents;Venous;willingness;Work

PROJECT_TITLE: Optimizing Vasopressor Delivery in Early Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10A-K (20)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: East Greenwich

ORG_NAME: GORDON RESEARCH CONFERENCES

ORG_STATE: RI

PHR: Project Narrative Since 1994, the biennial Biology of Spirochetes Gordon Research Conference has served as the foremost forum for researchers who study this diverse group of bacteria that include several successful pathogens. Since the spirochete phylum includes the bacteria that cause Lyme disease, syphilis, leptospirosis, relapsing fever, and intestinal spirochetosis, as well as bacteria that contribute to periodontal disease, the 2024 Biology of Spirochetes Gordon Research Conference will allow presentation and discussion of the frontiers of research relevant to both human and animal health.

PI_NAMEs: CAIMANO, MELISSA J (contact)

PROGRAM_OFFICER_NAME: STRICKLER-DINGLASAN, PATRICIA M

PROJECT_TITLE: 2024 Biology of Spirochetes Gordon Research Conference and Gordon Research Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-D (S2)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Genetics;Immunotherapy;Nutrition;Pancreatic Cancer;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is a highly lethal disease for which new therapeutic interventions are needed. The proposed project aims to develop a novel mouse model to determine whether increased production and activation of peroxisome proliferator-activated receptor delta (PPARD) in pancreatic cancer cells propels pancreatic cancer progression. New knowledge from this project is expected to help show whether drugs that are being developed to target PPAR-d function can be used to prevent pancreatic cancer.

PI_NAMEs: SHUREIQI, IMAD  (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Acceleration;Acinar Cell;Adult;Age;Binding;cancer cell;carcinogenesis;CCL2 gene;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Colon Carcinoma;CRISPR/Cas technology;cytokine;Data;Diet;dietary control;Dietary Fatty Acid;Disease;Doxycycline;drinking water;effective therapy;Epithelial Cells;Evaluation;Genetic Transcription;Granulocyte-Macrophage Colony-Stimulating Factor;High Fat Diet;Human;Immune;Immune system;Immunocompetent;immunodeficiency;Immunosuppression;Incidence;Individual;Inflammatory;insight;Interleukin-6;Intraepithelial Neoplasia;Knock-out;Knowledge;KPC model;KRAS2 gene;KRASG12D;Lentivirus;Ligands;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Messenger RNA;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;novel therapeutic intervention;Nuclear;Operative Surgical Procedures;Organ Donor;Organoids;overexpression;Palmitic Acids;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic Intraepithelial Neoplasia;Patients;Peroxisome Proliferator-Activated Receptors;Pharmaceutical Preparations;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor B;Platelet-Derived Growth Factor beta Receptor;PPAR delta;prevent;Prevention;Production;promoter;Proteins;receptor;recruit;Reporting;Resected;Role;T-Lymphocyte;Tamoxifen;Testing;Tissues;TP53 gene;Transplantation;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumor-immune system interactions

PROJECT_TITLE: PPARD hyperactivation promotes pancreatic intraepithelial neoplasia progression into pancreatic ductal adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-S (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Memory CD8 T cells are generated in response to infection or vaccination and form a critical component of antiviral immunity, rapidly responding to subsequent infections by killing virus-infected cells. These memory CD8 T cells are functionally diverse, with some better-suited than others to respond during infection, but little is known about how and why T cells develop to be more or less functional. This research will use cutting-edge techniques to track the development of CD8 T cells that recognize SARS-CoV-2, providing blueprints to design vaccines that provoke more effective responses and shedding light on multiple possible underlying causes of Long COVID.

PI_NAMEs: PAINTER, MARK M (contact)

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;Acute;adaptive immune response;Affect;Antibodies;antigen-specific T cells;Antigens;antiviral immunity;Automobile Driving;Blood specimen;breakthrough infection;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Cellular biology;Chromatin;Chronic;Clone Cells;cohort;combat;Complementary DNA;COVID-19 impact;COVID-19 pandemic;COVID-19 patient;COVID-19 severity;COVID-19 therapeutics;Custom;cytokine;debilitating symptom;design;Detection;Development;Disease;DNA sequencing;Epigenetic Process;Future;Goals;Homeostasis;Human;Immune;Immunity;Immunologic Memory;Immunologics;Immunology;Impairment;improved;Individual;Infection;Infection prevention;Influenza;influenzavirus;innovation;insight;Knowledge;Light;Long COVID;Malignant Neoplasms;Mediator;Membrane Proteins;Memory;Memory B-Lymphocyte;Mitochondria;Mitochondrial DNA;Molecular;Morbidity - disease rate;mortality;mRNA Expression;neutralizing antibody;novel;pandemic disease;pathogenic virus;Pathology;Peptides;persistent symptom;Persons;prevent;programs;Proliferating;protein expression;Research;Research Proposals;response;RNA;Sampling;Series;Serum;severe COVID-19;Severities;Shapes;single cell sequencing;Sorting;Symptoms;System;T cell differentiation;T cell response;T-Cell Receptor;T-Lymphocyte;Techniques;Technology;Testing;Time;Vaccination;Vaccine Design;vaccine efficacy;Vaccinee;Vaccines;Variant;Virus;Virus Diseases

PROJECT_TITLE: Elucidating the lineage dynamics of optimal human CD8 T cell responses to SARS-CoV-2 and how CD8 T cell homeostasis is altered in Long COVID

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE The critical importance of myelin for proper nervous system function is underscored by the devastating symptoms in diseases in which it is disrupted, including multiple sclerosis, leukodystrophies, and peripheral neuropathies that affect millions of Americans. It is also now becoming clear that myelin is a dynamic rather than a static structure that modulates neural plasticity in the healthy as well as diseased and injured central and peripheral nervous systems. The 2024 Myelin Gordon Research Conference and Seminar will bring together experts and trainees in the field of myelinating glial cell biology and repair to provide a forum to highlight recent advances in the field with a focus on themes of dynamism and plasticity.

PI_NAMEs: WOOD, TERESA L (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Academia;Acceleration;Achievement;Adult;Affect;Alzheimer's Disease;American;Animals;Axon;Biochemical;Biology;Biotechnology;Black race;California;Cell Communication;Cells;Cellular biology;Central Nervous System;central nervous system demyelinating disorder;central nervous system injury;Chemical Engineering;Data;Development;developmental disease;Disease;Disease Progression;Drug Industry;Emotional;Ensure;Environment;Faculty;Fostering;Future;Genetic Diseases;Goals;graduate student;Health;Holidays;Hour;human disease;improved;Industry;Injury;interest;International;Learning;leukodystrophy;Life;Mediating;meetings;member;Memory;Metabolic;Mexican Americans;Minority;Multiple Sclerosis;Myelin;myelination;Native Americans;Nature;Nervous System;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neuroglia;Neuronal Plasticity;Neurons;neuropsychiatric disorder;novel therapeutics;Oligodendroglia;Oral;Organism;Participant;Pathogenicity;Pathology;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Physiological;Physiology;Postdoctoral Fellow;posters;prevent;programs;Publishing;repaired;Research;Research Personnel;Role;Schwann Cells;Science;Scientist;Senior Scientist;Site;social;Societies;Structure;success;symposium;Symptoms;Therapeutic;Translations;white matter injury;Woman;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-P (11)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE:  Induction of plasticity is a potential therapeutic avenue for ameliorating neural deficits due to early perturbation, such as amblyopia, but the mechanisms underlying plasticity in the adult brain are not fully understood. This proposal will examine a novel form of adult plasticity in the visual cortex and identify how interneurons that express somatostatin (SST-INs) contribute to experience-dependent plasticity in mouse visual cortex. We expect our findings to provide important insights into the cellular underpinnings of plasticity in the adult brain.

PI_NAMEs: CARDIN, JESSICA A (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Adolescent;Adult;Amblyopia;area striata;Automobile Driving;Brain;Cells;Cerebral cortex;Cognition;Complex;Data;Dendrites;Development;Electrophysiology (science);Elements;Equilibrium;excitatory neuron;experience;Exposure to;Goals;hippocampal pyramidal neuron;Image;Injury;insight;Interneurons;Lead;Learning;Mediator;Methodology;Methods;microscopic imaging;movie;Mus;neural;neural circuit;Neuronal Plasticity;Neurons;novel;novel therapeutics;optogenetics;Pattern;Peptides;Physiology;Play;Population;response;Role;Sensory;sensory input;Shapes;Signal Transduction;Site;Somatostatin;Stimulus;Synapses;Therapeutic;Training;transmission process;two-photon;Vision;Visual;Visual Cortex;visual information;visual plasticity;visual processing;visual stimulus;Work

PROJECT_TITLE: Experience-dependent plasticity of circuit dynamics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Y (02)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Type one diabetes (T1D) is a chronic autoimmune condition resulting from the progressive destruction of insulin- producing β cells, leading to irreversible dysglycemia. It is well accepted that both immune system and β-cell dysfunction contribute to T1D pathogenesis, however many investigations of interventions focus on either the β cell or the immune system. Manipulation of the PGE2 signaling pathway, through its functionally opposing receptors EP3 and EP4, may provide an intervention which can simultaneously alter the autoimmune attack and provide cell-autonomous protection to the β cells, allowing delay, prevention, or reversal of disease pathogenesis.

PI_NAMEs: BURKETT, JULIANN B (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Affect;Affinity;antagonist;Antioxidants;Attenuated;Autoimmune;Autoimmune Diseases;autoimmune inflammation;autoimmune pathogenesis;Autoimmunity;Autophagocytosis;autoreactivity;Beta Cell;biological adaptation to stress;Blood Glucose;Cell Death;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cellular Stress;Chronic;Clinical;Clinical Trials;Couples;cytokine;Cytotoxic T-Lymphocytes;db/db mouse;Defect;Dendritic Cells;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;Dinoprostone;Disease;Disease Progression;endoplasmic reticulum stress;Environment;EP4 receptor;Equation;Exposure to;fluorescence imaging;Fostering;Functional disorder;Gene Expression;Gene Silencing;glucose monitor;GTP-Binding Protein alpha Subunits;Health;Hematoxylin and Eosin Staining Method;Histologic;Homeostasis;Human;Hyperglycemia;Immune;immune cell infiltrate;Immune system;Immune Targeting;Immunoglobulin Class Switching;Immunohistochemistry;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;Impairment;improved;in vivo;Inbred NOD Mice;Inflammation;Inflammatory;Inflammatory Response;Insulin;Insulin-Dependent Diabetes Mellitus;insulitis;Intervention;Invaded;Investigation;islet;Lesion;Leukocytes;Ligands;Link;lipid mediator;Lipids;Lipoxins;Literature;Lymphocyte;Macrophage;Mediating;Modeling;mouse model;Mus;Natural regeneration;Non obese;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Onset of illness;Oxidative Stress;Pancreas;Pathogenesis;Pathway interactions;Patients;Peptides;pharmacologic;Pharmacological Treatment;Phenotype;preservation;prevent;Prevention;Process;Production;Proliferating;protein expression;Proteins;receptor;Resolution;response;Role;senescence;senescence associated secretory phenotype;Side;Signal Pathway;Signal Transduction;Signaling Molecule;Stains;Stress;T-Lymphocyte;targeted treatment;therapeutic target;therapy design;tumor-immune system interactions;WFDC2 gene

PROJECT_TITLE: Targeting the Opposing Roles of Prostaglandin E2 Receptors, EP3 and EP4, in the Pathogenesis of Type One Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O1)]


NIH_SPENDING_CATS: Infectious Diseases;Kidney Disease;Urologic Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Kidney infection caused by Escherichia coli can lead to systemic infection, impaired renal function, or renal scarring. Recent work in mouse models shows that androgen exposure worsens pyelonephritis, often leading to abscess formation in the kidney. This project will define how an E. coli toxin called alpha-hemolysin (HlyA) promotes renal damage and how its toxic activity in the kidney is amplified by testosterone.

PI_NAMEs: KUHN, HUNTER W (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Abscess;Affinity;alpha Toxin;androgen sensitive;Androgenization;Androgens;antagonist;Antibodies;ascending urinary tract infection;Automobile Driving;Binding;Biological Assay;Bladder;C3H/HeN Mouse;Cations;Cell Culture Techniques;Cell Line;Cell membrane;cell type;Cells;Chronic;chronic infection;Clinical;Communication;Cystitis;cytokine;Cytolysis;cytotoxicity;Data;defined contribution;Development;Duct (organ) structure;Ductal Epithelial Cell;epidemiologic data;Epithelial Cells;Epithelium;Escherichia coli;Etiology;Exhibits;extracellular;Family;Female;Flow Cytometry;Fluorescence Microscopy;Health;Hematopoietic;Hemolysin;Histology;Hypertension;Immune response;Immunofluorescence Microscopy;Immunology;Impaired Renal Function;In Vitro;in vitro Model;in vivo;Infection;inhibitor;Investigation;Ion Channel;Ions;Kidney;kidney infection;knock-down;Leukocytes;male;Mammalian Cell;Measures;Mediating;Mediator;Modeling;Molecular;mouse model;Mus;mutant;neutrophil;Operon;Oral;Outcome;overexpression;P2X-receptor;Pathogenesis;Pathogenicity;Pathology;Patients;Permeability;pharmacologic;pre-clinical;Predisposition;Publishing;Quantitative Reverse Transcriptase PCR;receptor;recruit;release of sequestered calcium ion into cytoplasm;renal abscess;renal damage;renal epithelium;renal scarring;Renal Tissue;response;Risk;RNA;Role;Sex Bias;Small Interfering RNA;small molecule;Specific qualifier value;Systemic infection;Technical Expertise;Testing;Testosterone;Toxic effect;Toxin;Training;Transfection;Tubular formation;Update;Ureter;Urinary tract infection;Uropathogenic E. coli;Virulence;Western Blotting;Work;Writing

PROJECT_TITLE: Androgen Enhancement of E. coli Hemolysin Toxicity during Pyelonephritis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Eye Disease and Disorders of Vision;Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE The primary target of ∆9-Tetrahydrocannabinol (THC) is cannabinoid type-1 receptors (CB1Rs), which have been shown to be downregulated, desensitized, and internalized following chronic THC exposure, and can ultimately play a key role in synaptic plasticity and cannabinoid function. While there are numerous studies on the effects of chronic THC immediately following exposure, long-term effects and chronic prenatal THC exposure are poorly understood. This proposal will investigate the gap between previous literature that shows a decrease in CB1R expression and function and plasticity following chronic THC exposure, and our preliminary data, which shows that CB1R expression and cortical plasticity is increased two weeks after chronic THC exposure, and will ultimately inform novel therapeutic strategies for prenatal THC exposure.

PI_NAMEs: PRUITT, MOLLY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Affect;Agonist;Angelman Syndrome;Animal Model;Animals;Anxiety;area striata;attenuation;Binding;Brain;Cannabinoids;Cannabis;Cartoons;Cells;Chronic;CNR1 gene;comparison control;Control Animal;critical period;Data;density;desensitization;Development;Electrophysiology (science);Endocannabinoids;experience;experimental study;Exposure to;Eye;Eyelid structure;Ferrets;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;fetal marijuana exposure;Fetus;Growth;hippocampal pyramidal neuron;Human;illicit drug use;Impairment;in vivo;Interneurons;Ligands;Literature;Long-Term Effects;Maintenance;marijuana use in pregnancy;Measures;Messenger RNA;Modeling;monocular deprivation;Morphology;Nausea;Neocortex;Neurodevelopmental Disorder;neuron loss;Neurons;neurotransmission;novel;novel therapeutic intervention;Ocular Dominance;Parvalbumins;patch clamp;Phosphorus 32;Play;postnatal;postsynaptic;Pregnancy;Pregnant Women;prenatal;prenatal exposure;receptor expression;receptor function;Recommendation;Research Personnel;response;Rett Syndrome;Risk;ST13 gene;Stress;success;Surgical sutures;Symptoms;Synaptic plasticity;synaptogenesis;Testing;Tetrahydrocannabinol;THC exposure;Third Pregnancy Trimester;United States;Visual Cortex

PROJECT_TITLE: A Novel Animal Model to Investigate the Effects of Delta-9 - Tetrahydrocannabinol in the Primary Visual Cortex of Ferrets.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02A-W (20)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Astrocytes play important roles in health and disease but their role in the pathogenesis of Parkinson’s Disease (PD), as well as targets for their therapeutic modulation, are still largely unknown. I found that the sigma-1 receptor (SigmaR1) drives astrocyte disease-promoting responses in PD. In this project, I propose to define the role of SigmaR1 signaling in the control of astrocyte pathogenic responses in PD and evaluate its potential as a therapeutic target.

PI_NAMEs: PIESTER, GAVIN EDWARD (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: alpha synuclein;antagonist;arm;Astrocytes;astrogliosis;Cells;Central Nervous System;Central Nervous System Diseases;clinical training;Coculture Techniques;Conflict (Psychology);Corpus striatum structure;CRISPR/Cas technology;cytokine;Data;Development;Disease;disease model;dopaminergic neuron;Elements;endoplasmic reticulum stress;Experimental Autoimmune Encephalomyelitis;experimental study;Functional disorder;Genetic;Genetic Transcription;Gliosis;Health;In Vitro;in vitro activity;in vivo;Inflammation;Inflammatory;Inflammatory Response;Injections;Interleukin-1 beta;Knock-out;Laboratory Finding;Microglia;Modeling;monomer;motor deficit;motor symptom;mouse model;Multiple Sclerosis;Mus;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neurons;neurotoxic;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Persons;pharmacologic;Phosphorylation;Physicians;Play;pre-clinical;Pre-Clinical Model;pre-formed fibril;prevent;Prions;Process;Production;Proteins;Receptor Inhibition;Receptor Signaling;Recombinants;Regulation;Regulatory Pathway;Reporting;Research Training;response;Role;Scientist;Severity of illness;sigma-1 receptor;Signal Transduction;Stimulus;Testing;Therapeutic;therapeutic candidate;therapeutic target;Training;translational potential;transmission process;Up-Regulation;uptake;XBP1 gene

PROJECT_TITLE: Sigma-1 Receptor as a modulator of Astrocyte pro-inflammatory activities in Parkinson's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03C-N (20)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: ECHELON BIOSCIENCES, INC.

ORG_STATE: UT

PHR: A minority of alcohol users develop problem drinking patterns, or even worse a chronic alcohol use disorder, which exacts a huge toll on society. This proposal addresses the need for better detection of ethanol use/abuse using a direct biomarker for alcohol consumption. The rapid point-of-care lateral flow immunoassay developed in this project will provide a quick & reliable tool to monitor problem alcohol use, and help caregivers provide better treatments.

PI_NAMEs: NEILSEN, PAUL O (contact)

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Abstinence;Acute;Address;Agreement;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol monitoring;alcohol testing;alcohol use disorder;Alcohols;analytical method;Binding;Biological Markers;Biological Sciences;Blood;Caregivers;Caring;Cell membrane;Cellular Phone;checkup examination;Chronic;chronic alcohol ingestion;Clinical;Communication;Confusion;Consumption;contingency management;cost;Country;Detection;detection limit;Devices;Diagnosis;diagnostic biomarker;Direct Costs;drinking;Emergency department screening;Enzyme-Linked Immunosorbent Assay;Equipment;Erythrocytes;Ethanol;Evaluation;experience;follow-up;Forensic Medicine;Friends;Future;global health;Goals;Hand;Heavy Drinking;high risk drinking;high risk population;home test;Hospitals;Hour;Immunoassay;improved;In Vitro;Individual;Industry;innovation;Insurance;Intervention;Intoxication;Lateral;legal cases;Lipids;long term abstinence;Marketing;Mass Spectrum Analysis;Measures;medical specialties;Methods;Minority;Monitor;Monoclonal Antibodies;National Institute on Alcohol Abuse and Alcoholism;Nature;neonate;Pattern;Phase;phosphatidylethanol;point of care;point of care testing;Population;Preparation;Primary Care;Privatization;Procedures;Prognostic Marker;programs;Protocols documentation;prototype;Publications;Rapid screening;rapid testing;Reader;Research;Resource-limited setting;Rewards;Risk Assessment;Rural;Sampling;Security;Small Business Technology Transfer Research;Societies;Specimen;success;Test Result;Testing;Time;tool;Transplantation;Treatment Efficacy;Universities;Visual;Washington;Whole Blood;With laterality;Workplace

PROJECT_TITLE: Innovative Point-of-Care Solutions for Long-term Alcohol Biomarkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-J (10)]


ADMINISTERING_IC: HD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The glycine receptor type alpha 2 (GlyRα2) plays a role in neurogenesis, and mutations have been linked to neurodevelopmental disorders such as autism spectrum disorder and epilepsy. By investigating the structure-function relationship and lipidic profile of GlyRα2, this study aims to provide a better understanding of the role of this receptor in neurogenesis, adult physiology, and pathology. The knowledge gained from this study may lead to the development of pharmacologic therapies targeting GlyRα2 to help alleviate the symptoms of these disorders.

PI_NAMEs: KRUEGER, EMILY  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Address;Adult;Affect;Agonist;Anions;Area;autism spectrum disorder;Binding;Brain;Coupling;Cryoelectron Microscopy;Data;desensitization;Development;differential expression;Disease;Electrophysiology (science);Environment;Epilepsy;Estradiol;Extracellular Domain;Family;Future;Glycine;Glycine Receptors;Goals;Health;Human;Impairment;improved;interest;Investigation;Ion Channel;Ion Channel Gating;Kinetics;Knowledge;Length;Ligand Binding;Ligands;Link;Lipids;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Lipids;Membrane Proteins;Molecular;Molecular Conformation;motor learning;Movement;Mutation;Neonatal;Nervous System;nervous system development;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;new therapeutic target;patch clamp;Pathology;pharmacologic;Physiological;Physiology;Play;postsynaptic;Process;Progesterone;Property;Prosencephalon;Proteins;Rationalization;receptor;receptor function;reduce symptoms;Resolution;response;Role;Site;Site-Directed Mutagenesis;Specificity;Structure;Structure-Activity Relationship;Synapses;Synaptic Transmission;targeted treatment;Testing;Therapeutic;Time;Transmembrane Domain;Work

PROJECT_TITLE: Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Microbiome;Rheumatoid Arthritis

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates the novel use of live engineered bacteria for the oral delivery of peptide drugs, specifically for treating autoimmune disease. These investigations will enable new microbe-based drug delivery strategies, enhancing access to care with the potential to significantly advance our understanding of gut microbe behavior. Therefore, the proposed research contributes to the NIH’s mission of seeking knowledge on the behavior of living systems and applying it to reduce illness.

PI_NAMEs: KADY, MOHAMED RYAN (contact)

PROJECT_TERMS: absorption;Address;Adherence;Adhesions;analog;Anatomy;arm;Arthritis;Autoimmune;autoimmune arthritis;Autoimmune Diseases;Bacteria;Behavior;Biological Assay;Biological Availability;Biological Response Modifier Therapy;Biomedical Engineering;Blood Circulation;capsule;career;Cell Proliferation;Cells;Circulation;Clinical Treatment;Clinical Trials;Collaborations;Collagen Arthritis;Data;design;Development;Diffusion;Disease;Drug Delivery Systems;Electrophysiology (science);Elements;Enabling Factors;Engineered Probiotics;Engineering;Enteral;Environment;Epithelial Cells;Epithelium;experience;experimental study;FDA approved;Formulation;gastrointestinal epithelium;Goals;gut bacteria;gut microbes;Health;Health Services Accessibility;host-microbe interactions;Human;human disease;Immune;Immunofluorescence Microscopy;Immunology;Immunomodulators;immunoregulation;improved;in vivo;Injections;insight;Integration Host Factors;Interdisciplinary Study;interest;Intestinal Mucosa;Intestines;Intrinsic factor;Investigation;investigator training;Knock-out;Knowledge;Lactobacillus reuteri;Length;Location;Measures;Mediating;Microbe;microbial;microbial products;Microbiology;Microscopy;Mission;Modality;Molecular;Molecular Weight;Mucous body substance;Mucous Membrane;novel;novel therapeutics;Oral;Oral Administration;oral bacteria;Organism;Outcome;Pathway interactions;peptide drug;Peptides;Permeability;Pharmaceutical Preparations;Physicians;Principal Investigator;Probiotics;Property;Proteins;Public Health;Publishing;Rattus;recombinant peptide;Research;Scientist;Serum;side effect;Small Intestines;Structural Protein;synthetic peptide;Testing;Therapeutic Effect;Tight Junctions;Tissues;Training;Treatment Efficacy;United States National Institutes of Health;Weight

PROJECT_TITLE: Mechanisms enabling the oral-to-systemic absorption of a microbially delivered immunomodulatory peptide


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative TDP-43 pathology, due to loss of TDP-43 nuclear function, is a hallmark of several neurodegenerative diseases including mixed etiology dementias (MEDs) such as Alzheimer’s Disease with TDP-43 pathology (AD-TDP) and frontotemporal dementia (FTD). Proposed studies will elucidate the role of TDP-43 in the pathological conversion and “prion-like” spreading of tau protein in the presence or absence of ß-amyloidosis. These mechanistic insights can guide the development of novel therapeutic approaches for MEDs currently without effective treatment.

PI_NAMEs: BURNS, GRACE D (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;aged;aging population;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloidosis;Autopsy;beta amyloid pathology;Biochemical;Bioinformatics;biomarker development;Cause of Death;cerebral atrophy;Classification;collaborative environment;corticobasal degeneration;Cytoplasm;Data;Dementia;Development;Disease;Disease Progression;DNA;effective therapy;Exhibits;Exons;experimental study;Frontotemporal Dementia;Functional disorder;genetic signature;Goals;Hippocampus;Human;human disease;human tissue;Impaired cognition;Injections;insight;Knockout Mice;Laboratories;Mediating;Mentors;Mentorship;Microglia;mixed dementia;Modeling;Molecular;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;neuron loss;Neurons;new therapeutic target;novel;novel therapeutic intervention;Nuclear;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phenotype;Play;Population;prion-like;Prosencephalon;protein TDP-43;Repression;Research;Risk Factors;RNA Splicing;RNA-Binding Proteins;Role;Scientist;Senile Plaques;Silver Staining;single-cell RNA sequencing;skills;Synapses;Tars;tau Proteins;Tauopathies;Techniques;Testing;Therapeutic;therapeutic target;Tissues;Training;Transgenic Model;United States;Wild Type Mouse;Work;Writing;young adult

PROJECT_TITLE: Characterizing novel Mixed Etiology Dementia models compromised for TDP-43 function


NIH_SPENDING_CATS: Diabetes;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Narrative Diabetic retinopathy (DR) is a microvascular retinal complication of diabetes mellitus that leads to breakdown of the blood retinal barrier (BRB). Building on prior work in the lab suggesting that hyperinsulinemia induces BRB breakdown under hyperglycemic conditions, we will investigate the effects of insulin on tight junction proteins of the RPE. This proposal will broaden our understanding of the pathogenesis of DR and could potentially identify therapeutic targets for macular edema

PI_NAMEs: HERNANDEZ, KAREN  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Age;Animals;Binding;Blindness;Blood Vessels;Blood-Retinal Barrier;C-terminal;Cell Line;Cell Maintenance;Cell Polarity;Cells;Centers for Disease Control and Prevention (U.S.);Chronic;Co-Immunoprecipitations;Complications of Diabetes Mellitus;Cytoplasm;Defect;Developed Countries;Development;Diabetes Mellitus;diabetic;diabetic patient;Diabetic Retinopathy;Diffusion;Disease;Endothelial Cells;Epidemic;Event;experimental study;Exposure to;extracellular;Family;Family suidae;Glucose;Human;Hyperglycemia;Hyperinsulinism;improved;In Vitro;in vivo;Individual;Insulin;Insulin Resistance;insulin secretion;Integral Membrane Protein;Ions;Laboratories;Liquid substance;Literature;macula;macular edema;Membrane;Metabolic Diseases;Modeling;Molecular;Movement;Multiprotein Complexes;Mutation;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Pathogenesis;Peripheral;Permeability;Persons;Post-Translational Protein Processing;Prevalence;Process;Property;Protein Family;Proteins;Regulation;Retina;Role;single-cell RNA sequencing;small molecule;Structure of beta Cell of islet;Structure of retinal pigment epithelium;Testing;therapeutic target;Tight Junctions;Tissues;Vascular Endothelial Cell;Vision;Visual impairment;Work;Zebrafish

PROJECT_TITLE: Role of Hyperglycemia/Hyperinsulinemia in the Breakdown of the Blood Retinal Barrier in Diabetic Retinopathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The study of cortical and subcortical communication in the oculomotor system offers insights into how the brain represents and transforms information to produce eye movements, a fundamental human behavior. An understanding of how visual-motor structures communicate is a key step in the development of clinically useful brain-computer interfaces for the restoration of sight as well as the development of affordable, non-invasive assessments of eye movements for the detection and monitoring of numerous diseases.

PI_NAMEs: WILLETT, SHAWN  (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: analytical tool;Area;Behavior;Behavioral;Biological;Biological Markers;Brain;brain computer interface;Brain region;clinical development;Cognition Disorders;Communication;Complex;Data Analytics;Detection;Development;Diagnosis;Dimensions;Disease;Eye;Eye Development;Eye Movements;Failure;fovea centralis;frontal eye fields;Future;health assessment;high dimensionality;Human;insight;kinematics;Knowledge;Maintenance;Masks;Measures;Midbrain structure;Modernization;Monitor;Monkeys;Motion;Motor;Movement;multidimensional data;Neurodegenerative Disorders;Neurons;Neurosciences;oculomotor;Population;Population Dynamics;Prefrontal Cortex;Primates;Privatization;Production;rapid eye movement;Reaction Time;research clinical testing;Role;Saccades;Sensory;Shapes;sight restoration;Smooth Pursuit;Structure;superior colliculus Corpora quadrigemina;System;Vision;Visual;visual motor;visual tracking;Work

PROJECT_TITLE: The cortical and subcortical control of coordinated eye movements

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-Y (20)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative Anti-tumor immune responses and response to immunotherapy rely on direct recognition by cytotoxic CD8 T cells of antigens presented on the surface of tumor cells. Tumors like melanoma suppress native immune response through induction of T cell dysfunction and exhaustion, but the direct interactions between tumor- specific CD8 T cells and cells in the tumor leading to dysfunction are incompletely understood. Investigation of the anti-tumor T cell specificities required for tumor control, and the intratumoral interactions of tumor-specific CD8 T cells in melanoma, will contribute to a better understanding of the mechanisms driving anti-tumor T cell responses and pave the way for future TCR-based therapeutic approaches.

PI_NAMEs: AFEYAN, ALEXANDER BADRIG KJELL (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Achievement;Address;Adoptive Cell Transfers;Animal Model;anti-CTLA4;anti-PD-1;anti-tumor immune response;Antigen Presentation;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigenic Diversity;Antigens;Antitumor Response;arm;Autologous;Automobile Driving;Avidity;Bar Codes;Biopsy;cancer cell;cancer infiltrating T cells;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cells;Cellular biology;cellular transduction;Clone Cells;cytotoxic;cytotoxic CD8 T cells;cytotoxicity;Data;exhaust;exhaustion;Experimental Designs;experimental study;Functional disorder;Future;Genetic Heterogeneity;Human;Immune;immune checkpoint blockade;Immune response;Immunity;immunoregulation;Immunotherapy;In Vitro;in vivo;Individual;Infiltration;insight;Investigation;Link;Maps;Mediating;Melanoma;Melanoma patient;Melanoma Tumor;mouse model;Mus;neoantigens;neoplastic cell;patient derived xenograft model;Patients;Phenotype;pressure;Property;reconstruction;Recurrence;Recurrent tumor;Refractory;Relapse;Renal Cell Carcinoma;Resistance;response;Role;sequencing platform;single cell sequencing;Slide;Solid Neoplasm;Specificity;Surface;System;T cell infiltration;T cell receptor repertoire sequencing;T cell response;T-Cell Antigen Receptor Specificity;T-cell diversity;T-Cell Immunologic Specificity;T-Cell Receptor;T-cell receptor repertoire;T-Cell Receptor Therapy;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;transcriptomics;tumor;Tumor Antigens;tumor growth;Tumor Markers;tumor microenvironment;tumor specificity;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes

PROJECT_TITLE: Defining the functional and spatial properties of tumor-specific tumor-infiltrating CD8 T cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09C-Z (20)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Physical Injury - Accidents and Adverse Effects

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative Musculoskeletal tissues like tendon undergo a variety of mechanical changes at the microscale that lead to inferior tissue-level mechanics and increased rupture rates. The purpose of this study is to elucidate the role of glycosaminoglycans in fatigue-induced rupture in aging and healing Achilles tendons using a multiscale experimental and computational approach. This research will innovate current biomechanical evaluations of tendon rupture due to fatigue, enhance our understanding of how tendon ruptures occur in vulnerable populations, and inform future treatments to improve tendon function and prevent injury.

PI_NAMEs: BLANK, JONATHON  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Glycosaminoglycan-mediated fibril sliding and its role in fatigue-induced microdamage and rupture in aged and healing Achilles tendons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-C (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Influenza;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia and Influenza;Pregnancy;Prevention;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Pregnant people, fetuses, and infants are at increased risk of influenza-associated morbidity and mortality, which can be prevented by administering seasonal influenza vaccine during pregnancy. Leveraging data from a previously conducted maternal influenza vaccine RCT in Nepal, this project seeks to close gaps in knowledge in low- and middle-income countries (LMICs) pertaining to maternal influenza disease severity, the impact of maternal influenza vaccination on infant growth, the optimal timing of vaccination during pregnancy, and the cost-effectiveness of this intervention. These data could inform vaccine policy changes, facilitate implementation of maternal influenza vaccines in LMICs, and provide opportunities for the F31 candidate to gain expertise in new methods and advance as an independent investigator studying maternal immunization.

PI_NAMEs: FRIVOLD, COLLRANE  (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: Accounting;adverse birth outcomes;Age Months;Anthropometry;antibody transfer;arm;Behavior;Birth;Birth Weight;Budgets;burden of illness;care seeking;career;Cessation of life;Communities;cost;cost effective;cost effectiveness;cost-effectiveness ratio;Country;Data;Death Rate;Decision Trees;Disease;Disease Outbreaks;disparity reduction;Effectiveness of Interventions;Enrollment;Epidemiology;Equity;evidence base;experience;fetal;Fetal Growth;Fetus;Fever;flu transmission;Goals;Growth;Head circumference;Health;health economics;high risk;Household;Immunization Programs;implementation facilitation;Income;incremental cost-effectiveness;Individual;Infant;Infant Mortality;infant outcome;Infection prevention;Infectious Disease Epidemiology;Influenza;influenza surveillance;Influenza vaccination;influenza virus vaccine;Intervention;Investments;Knowledge;Lead;Length;Life;Live Birth;Logistic Regressions;low and middle-income countries;Lower Respiratory Tract Infection;Maternal antibody;maternal comorbidity;maternal vaccination;Measures;Mentorship;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Mothers;Neonatal Mortality;Nepal;Outcome;Parents;Participant;Persons;phase 4 study;Placebo Control;placebo group;Placebos;Placenta;Policies;Population;Positioning Attribute;Postpartum Period;pre-doctoral;Pregnancy;pregnant;Premature Birth;prevent;public health intervention;Randomized;Randomized, Controlled Trials;Recommendation;Reporting;Research;research data dissemination;Research Personnel;Research Project Grants;Resource-limited setting;Resources;respiratory pathogen;Risk;Risk Estimate;Rural;seasonal influenza;Second Pregnancy Trimester;secondary analysis;Services;Severity of illness;stillbirth;Surveys;Symptoms;System;Testing;Third Pregnancy Trimester;Time;Training;Vaccinated;Vaccination;vaccine access;vaccine effectiveness;vaccine efficacy;vaccine evaluation;Vaccinee;Vaccines;Visit;Weights and Measures;World Health Organization

PROJECT_TITLE: Associations between influenza vaccination during pregnancy and outcomes related to maternal influenza disease, infant anthropometry, and cost-effectiveness in rural Nepal

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F18-E (20)]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Genetics;Neurosciences;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: BELAY DIAGNOSTICS, LLC

ORG_STATE: IL

PHR: PROJECT NARRATIVE Belay Diagnostics has developed and validated a highly sensitive and specific multi-omic technology, CSF-TumorDx, that can detect tumor derived DNA in cerebrospinal fluid to aid in the diagnosis of brain cancers. In this Fast-Track application we will: i) establish pre-analytic quality control procedures, ii) determine the analytical sensitivity and specificity of CSF-TumorDx and iii) determine the clinical validity of CSF-TumorDx. Belay Diagnostics will work closely with investigators at the Johns Hopkins University School of Medicine to validate the performance of CSF-TumorDx and at the completion of this proposal will have a CLIA certified test ready for clinical implementation and commercialization.

PI_NAMEs: BETTEGOWDA, CHETAN ;COE, BRIAN  (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: Address;Alleles;Aneuploidy;Anxiety;Benchmarking;Benign;Biological Assay;Biological Markers;Biopsy;Blinded;Blood;Blood Circulation;Brain;brain abnormalities;Brain imaging;brain magnetic resonance imaging;Brain Neoplasms;burden of illness;Cancer Detection;Cancer Patient;Cells;Cerebrospinal Fluid;Circulation;CLIA certified;Clinical;clinical implementation;clinical practice;Collaborations;Collection;commercialization;Consultations;Credentialing;Data;Demyelinating Diseases;design;Detection;detection assay;detection limit;Developmental Process;Diagnosis;Diagnostic;Disease;DNA;Etiology;experience;Financial Hardship;Genes;Glioblastoma;Glioma;Grant;Health Personnel;Image;Incidental Findings;Individual;Inflammatory;Lesion;Liquid substance;Magnetic Resonance Imaging;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Measures;medical schools;Methodology;minimally invasive;Molecular;molecular diagnostics;MRI Scans;multiple omics;mutant;Mutation;neoplastic;Nervous System Trauma;neuro-oncology;Neurologic;neurosurgery;Neurosurgical Procedures;new technology;Non-Malignant;Oncology;Operative Surgical Procedures;optimal treatments;Patients;Performance;Phase;Plasma;Procedures;Process;Protocols documentation;Quality Control;Recording of previous events;Research Personnel;Risk;sample collection;Sensitivity and Specificity;serial imaging;Shipping;Somatic Mutation;Specialist;Specificity;Techniques;Technology;Testing;Tube;tumor DNA;Tumor Markers;Tumor-Derived;Uncertainty;United States;Universities;Validation;Work;X-Ray Computed Tomography

PROJECT_TITLE: Multi-omic CSF Assay for the Diagnosis of Brain Cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Whether obesity is unhealthy depends in large part upon the balance between maladaptive fat expansion via adipocyte hypertrophy (growth in pre-existing fat cells) and metabolically protective fat expansion via adipocyte hyperplasia (increasing numbers of new fat cells). In this proposal, we will investigate the potential of insulin-like growth factor 2 (IGF2) to promote adipocyte progenitor proliferation and differentiation, the dynamic processes that drive hyperplastic fat expansion. The results of this proposal will provide a better understanding of whether enhanced IGF2 action in adipocyte progenitors is a viable strategy for promoting hyperplastic fat expansion and uncoupling obesity from metabolic disease.

PI_NAMEs: SHARMA, ANKIT  (contact)

PROJECT_TERMS: Address;adipocyte differentiation;Adipocytes;Adipose tissue;Age;age related decline;Aging;Attenuated;Bioinformatics;Biological Assay;Blood;Calories;Cardiomyopathies;Cardiovascular Diseases;career;cdc Genes;Cell Cycle Inhibition;cell growth;Cell Proliferation;Characteristics;Clonal Expansion;Data;Development;Diabetes Mellitus;diet-induced obesity;differential expression;Down-Regulation;Enhancers;Equilibrium;Fatty acid glycerol esters;fatty liver disease;Fibrosis;Flow Cytometry;follow-up;Follow-Up Studies;Functional disorder;gain of function;Gene Expression;Goals;Growth;Health;Heart;High Fat Diet;Human;Hyperplasia;Hypertrophy;IGF2 gene;Impairment;in vivo;Inflammation;Insulin Resistance;Insulin-Like Growth Factor II;Isotopes;Knowledge;Link;lipid biosynthesis;Lipids;Liver;loss of function;Luciferases;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;metabolomics;Mitotic;Molecular;mouse model;Mus;novel;novel therapeutic intervention;Obesity;Pathologic;Phase;Physicians;Physiology;Play;postnatal;postnatal development;preservation;Process;progenitor;Proliferating;Recombinant Insulin-Like Growth Factor;Research;Role;Scientist;single-cell RNA sequencing;Skeletal Muscle;stable isotope;stem cell differentiation;stem cell proliferation;subcutaneous;Techniques;Testing;Therapeutic Intervention;Tissues;Training;transcriptome sequencing;Weight Gain;Work

PROJECT_TITLE: Defining the role of IGF2 in regulating adipocyte progenitor proliferation and adipogenesis


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: GRAND FORKS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: Project Narrative This proposal requests support of two symposia specifically related to aging. The Sixteenth and Seventeenth International Symposia on Neurobiology and Neuroendocrinology of Aging will be held July 12-16, 2024 and in July 2026. These meetings focus on mechanisms of aging with an emphasis on the central nervous system including both neuronal and hormonal aspects in addition to age-related disease.

PI_NAMEs: BROWN-BORG, HOLLY M. (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Age;age related neurodegeneration;age-related disease;aged;Aging;aging mechanism;aging related;Alzheimer's Disease;Area;Austria;Award;Biology of Aging;Central Nervous System;Clinical;Collaborations;Communication;deregulated nutrient-sensing;Dietary Intervention;Disease;Endocrine system;Endocrinology;Environment;Epigenetic Process;Faculty;Funding;Genomic Instability;Geriatrics;Gerontology;Geroscience;graduate student;Health;Hormonal;hormone deficiency;Human;Impaired cognition;Inflammation;interest;International;Intervention;Investigation;Journals;lectures;Left;Link;Mediator;meetings;Metabolic dysfunction;Mitochondria;mitochondrial dysfunction;Modeling;Molecular Biology;Neurobiology;Neurodegenerative Disorders;Neuroendocrinology;Neurons;neuroprotection;novel;Oral;Oxidation-Reduction;Parkinson Disease;Participant;Pharmaceutical Preparations;Population;Positioning Attribute;Postdoctoral Fellow;posters;Publishing;Regenerative research;Rejuvenation;Request for Applications;Request for Proposals;Research;Research Personnel;Schedule;Science;Scientist;senescence;Senior Scientist;Series;Slide;stem cell exhaustion;student conference;symposium;Technology;Tissues;Training;translational potential;Travel;United States

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Rheumatoid arthritis (RA) affects approximately 1% of the population and can lead to significant morbidity, in- creased mortality, and substantial health-care and societal costs. This project will study two immune cell sub- sets from the lung to understand whether they are involved in the production of RA-related antibodies in the lung during the early phases of RA development. Ultimately, these findings can lead to novel approaches for RA prevention that target these cells or proteins produced by these cells.

PI_NAMEs: DEMORUELLE, M. KRISTEN  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Ancillary Study;Antibodies;Antibody Formation;Autoantibodies;B cell differentiation;B-Lymphocyte Subsets;CD14 gene;Cells;cellular targeting;Classification;Clinical Research;Clinical Trials Design;comparison control;CXCL13 gene;cyclic citrullinated peptide;cytokine;Data;Development;Disease;disorder prevention;FCGR3B gene;Flow Cytometry;Gene Expression Profile;Generations;Health Care Costs;Helper-Inducer T-Lymphocyte;high risk;Immune;Individual;Inflammation;interleukin-21;Interleukin-6;joint inflammation;Joints;Lung;Macrophage;monocyte;Morbidity - disease rate;mortality;novel;novel strategies;Parents;Pathogenesis;Pathway interactions;Patients;Peripheral;peripheral blood;Phase;Population;pre-clinical;prevent;Prevention;Prevention trial;Production;Proteins;Public Health;Publishing;Research;Rheumatoid Arthritis;Rheumatoid Factor;Role;Sampling;Serum;Site;societal costs;Sorting;Sputum;Strategic vision;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Time;Tissues;transcriptome sequencing;United States National Institutes of Health

PROJECT_TITLE: Sputum Tph cells and CD14+CD16+ monocytes in the development of RA

STUDY_SECTION_NAME: Special Emphasis Panel[ZAR1 SP (M1)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Precision Medicine;Women's Health Research

PHR: This research is clinically relevant as it aims to improve the accuracy of assessing HER2 expression in breast cancer patients, particularly those with HER2-low/negative tumors, and to develop personalized treatment strategies for these patients. Subclassifying breast cancer by quantitatively measuring spatial HER2 expression patterns using our proposed high-sensitivity HER2 assay and morphologic, deep learning-based approaches could lead to better patient selection for trastuzumab deruxtecan therapy, ultimately improving treatment outcomes and reducing healthcare costs. The research also has the potential to advance our understanding of the pathologic and spatial biomarker expression parameters that influence antibody-drug conjugate therapy response, contributing to the advancement of cancer medicine.

PI_NAMEs: ROBBINS, CHARLES JOHN (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Algorithms;anti-cancer research;Antibody-drug conjugates;Architecture;Biological Assay;Biological Markers;BRAF gene;Breast Cancer Patient;Breast Cancer therapy;Bystander Effect;Cells;Characteristics;Classification;Clinical;Clinical Trials;clinically relevant;cohort;companion diagnostics;Computer Vision Systems;convolutional neural network;Data;Data Set;deep learning;design;diagnostic strategy;ERBB2 gene;ERBB2 Gene Amplification;Estrogen receptor positive;Gene Amplification;Guidelines;Health Care Costs;Heterogeneity;Image;Immunofluorescence Immunologic;Immunohistochemistry;Immunotherapy;improved;In Vitro;innovation;insight;investigator-initiated trial;learning strategy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Maps;Measurable;Measures;Medicine;Modernization;Morphology;mosaic;multitask;Mutation;new therapeutic target;novel diagnostics;novel therapeutics;objective response rate;Oncologist;Oncoproteins;overexpression;Pathologic;Pathologist;Pathology;Patient Selection;patient stratification;Patients;Pattern;personalized medicine;Primary Neoplasm;prospective;Registries;Reproducibility;Research;response;Selection for Treatments;Side;Specimen;Stains;Supervision;targeted treatment;Techniques;Testing;Theoretical model;Tissues;Training;Trastuzumab;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;tumor;tumor heterogeneity;Variant;virtual;whole slide imaging;Work

PROJECT_TITLE: Next-generation diagnostic approaches for HER2-low breast cancer and trastuzumab deruxtecan therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F09B-Z (20)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Physical Activity;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative An unacceptably high risk for second ACL injuries exists for young and physically active individuals who suffer a first-time anterior cruciate ligament (ACL) injury and opt for surgical reconstruction to restore stability in preparation to return to pre-injury levels of activity. The current ancillary study aims to develop a predictive model for underlying kinematic mechanisms for this increased risk of re-injury by using easily accessible, open-source, markerless video capture technology combined with innovative data processing techniques to derive movement coordination features during single-leg jump maneuvers. The findings of this study will provide an evidence-based approach for personalized & precision care for patients recovering from ACL reconstruction surgeries that leverages current data analytics and technology to better inform healthcare decisions and to promote health and well-being through safe engagement in physical activity despite prior injury and surgery.

PI_NAMEs: HART, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Ancillary Study;Ankle;ankle joint;Anterior Cruciate Ligament;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;anterior cruciate ligament rupture;Applications Grants;Area;Award;Bilateral;Caring;Clinical;Clinical Data;clinical translation;Computer software;computerized data processing;Consumption;Contralateral;cost;Data;Data Analytics;Data Collection;Detection;Devices;Electronics;empowerment;Enrollment;Ensure;Environment;Equipment;evidence base;Female;Funding;Grant;Health Promotion;Healthcare;high risk;Hip region structure;improved;Individual;Infrastructure;Injury;innovation;instrument;Investments;joint mobilization;Joints;kinematics;Kinetics;Knee;Laboratories;Leg;Limb structure;male;Measures;Medical;Methods;Modeling;Motion;Movement;muscle strength;open data;open source;Operative Surgical Procedures;Outcome;parent grant;Parents;Participant;participant enrollment;Patient Care;Patient Outcomes Assessments;Patient Recruitments;Patients;Pattern;Personal Satisfaction;personalized approach;personalized care;Physical activity;Physicians;Positioning Attribute;predictive modeling;Preparation;prevent;Procedures;Process;prognostic;prognostic model;Reconstructive Surgical Procedures;recruit;Recruitment Activity;Rehabilitation therapy;Research;Research Project Grants;Risk;Risk Factors;Rupture;Sample Size;Sampling;Schedule;Scientist;Sensitivity and Specificity;sensor;Series;Shoes;Site;Surveys;Technical Expertise;Techniques;Technology;Testing;Time;timeline;tool;Travel;United States National Institutes of Health;Virginia;Visit;wearable data;wearable sensor technology;women patients

PROJECT_TITLE: Predicting second injuries after primary ACL reconstruction using clinically accessible videography


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: CHEMISTRY

PHR: Project Narrative:  This project aims to seek to understand the role of histone marks in immune and blood cell development and why stem cells differentiate non-uniformly into one or another possible lineage (e.g., T-cells or B-cells). This improved understanding has the potential to significantly benefit bone marrow transplantation outcomes.

PI_NAMEs: WONG, MADELINE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: B-Lymphocytes;Biomedical Research;Blood;Blood Cells;Bone Marrow Transplantation;Cell division;Cell Lineage;cell type;Cells;ChIP-seq;Clonal Hematopoietic Stem Cell;Communities;Coupling;Decision Making;Development;Discipline;Environment;Epigenetic Process;epigenetic regulation;Evaluation;Generations;Genes;Genetic Transcription;Genome;genomic locus;Health;Hematopoiesis;hematopoietic stem cell differentiation;Hematopoietic Stem Cell heterogeneity;Hematopoietic stem cells;Heritability;Heterogeneity;histone modification;Histones;Human;Image;imaging modality;Immune;Immune system;improved;In Vitro;Individual;Inherited;interest;Macrophage;Malignant Neoplasms;Measures;Methodology;Methods;Natural regeneration;Outcome;Polymerase;Population;preference;premature;Proteins;Regulator Genes;Repression;Research Personnel;Role;self-renewal;Shapes;Somatotype;Specific qualifier value;stem;stem cell biology;stem cell differentiation;stem cell population;stem cells;superresolution microscopy;T-Lymphocyte;Testing;Work

PROJECT_TITLE: Investigating the Impact of Epigenetic Heterogeneity on Hematopoiesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10C-D (20)]


NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Palliative Care

PHR: Project Narrative Patients supported by extracorporeal membrane oxygenation (ECMO) and their families likely have numerous palliative care needs due to high mortality and complication rates for patients, increased psychological distress for families, and the unique ability of ECMO to support life nearly indefinitely even when prognosis is very poor. Despite the exponentially increasing use of ECMO for cardiac and pulmonary failure, research into the palliative care needs of these patients and their families is lacking. This project aims to better understand which patients on ECMO are receiving specialty palliative care support, what type of support palliative care services are providing, and what types of support patients and their family members need.

PI_NAMEs: KIKER, WHITNEY ALLYN (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Brain Injuries;Address;Adoption;Age;Award;care systems;Caring;Caucasians;Cessation of life;Chronic Disease;Clinical;clinical care;Communication;Complex;Complication;conflict resolution;Consultations;Critical Illness;Data;Decision Making;design;Development;Distress;Electronic Health Record;Environment;experience;Extracorporeal Membrane Oxygenation;Face;Family;Family member;Future;Goals;Heart failure;Hospitals;improved;Intensive Care Units;Intervention;Intervention Trial;Interview;K-Series Research Career Programs;Life;Literature;loved ones;lung failure;Medical;medical complication;medical specialties;Medicine;Mentorship;Methodology;Methods;mortality;Multiple Organ Failure;Needs Assessment;older patient;Palliative Care;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Physicians;Play;Population;Positioning Attribute;Process;Prognosis;prognostic;psychological distress;psychosocial;Psychosocial Assessment and Care;Recovery;Research;Research Personnel;Research Project Summaries;Research Training;Respiratory Failure;Role;Sampling;Scientist;Sepsis;Services;Severity of illness;shared decision making;skills;Specialist;Statistical Data Interpretation;Stress;Structure;success;surrogate decision maker;symptom management;Technology;therapy design;therapy development;Time;Uncertainty;Universities;Visit;Washington;Withdrawal

PROJECT_TITLE: Palliative Care Utilization and Needs Assessment for Patients on Extracorporeal Membrane Oxygenation and their Families

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-H (20)]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative The recently developed charge-altering releasable transporter (CART) gene delivery vectors exhibit remarkable efficiency for mRNA transfection and expression with site specific selectivity and low cytotoxicity. We propose to study the structure-property-function relationship of mRNA/CARTs complexes with advanced microscopy and scattering techniques to elucidate how physicochemical properties affect nanostructure. Distinct formulations will be further screened to relate biological function to structure allowing for the establishment of a set of design rules to aid the development of CARTs for efficient and selective immunotherapies.

PI_NAMEs: HURST, PAUL JOSHUA (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affect;Benchmarking;Biological;Biological Process;cancer therapy;career;career development;Cations;Cell Culture Techniques;Cells;Cellular Assay;Charge;Chemical Structure;Chemicals;Chemistry;Collaborations;Complex;COVID-19 vaccine;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;cytotoxicity;Data;delivery vehicle;design;Development;Educational process of instructing;electron tomography;Environment;Exhibits;Formulation;Freeze Drying;functional outcomes;Future;Gene Delivery;gene therapy;Goals;Immunotherapy;improved;In Situ;In Vitro;in vivo;insight;Laboratories;lipid nanoparticle;Lipids;Liver;Lung;Measurement;Medicine;Mentors;Messenger RNA;Methods;Microfluidics;Microscopy;Modeling;Morphology;mouse model;mRNA delivery;mRNA Translation;nano;nanoparticle;Nanostructures;Nature;next generation;Organ;Ornithine;outreach;particle;Phase;physical property;professor;Property;Protocols documentation;Research;responsible research conduct;RNA;Roentgen Rays;Sampling;Site;skill acquisition;Spleen;Structure;System;targeted treatment;Techniques;therapeutic RNA;therapeutically effective;Training;Transfection;Transmission Electron Microscopy;Universities;Unsaturated Fats;Vaccination;Variant;zeta potential

PROJECT_TITLE: Structure-Property-Function Relationship in mRNA/CARTs for Targeted mRNA Delivery


PHR: PROGRAM OVERALL – Project Narrative - CCHI Enteric bacterial infections include different types of diarrheal illnesses caused by pathogenic Salmonella and Shigella which afflict major populations around the world, particularly in developing nations, disproportionally affecting children. The development of new and improved vaccines is hampered because we do not fully understand how the human immune system operates to protect children and adults from these infections. To address these problems, the central theme of our “Mechanisms of Mucosal and Systemic Immunity to Vaccination and Infection with Enteric Pathogens in Children and Adults” CCHI application is to further our understanding of the immune mechanisms that operate in both systemically and in the gut mucosal environment, by using unique human infection and vaccination models of Salmonella and Shigella.

PI_NAMEs: SZTEIN, MARCELO B. (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Acceleration;adaptive immunity;Address;Adjuvant;Adjuvanticity;Adult;Affect;Architecture;arm;ATAC-seq;Attenuated;B-Lymphocytes;Bacterial Infections;Bioinformatics;Biometry;Cells;Characteristics;Child;Clinical;Clinical Research;Cytometry;Data;data integration;Developing Countries;Development;diarrheal disease;Disease;Distal part of ileum;Duodenum;Enteral;enteric pathogen;Environment;Epigenetic Process;Epithelial Cells;Epithelium;Exposure to;Future;Gene Expression Profile;Genomics;global health;Goals;Gut Mucosa;Helper-Inducer T-Lymphocyte;Human;Image;Immune;Immune response;Immune system;Immunity;Immunization;Immunize;Immunologics;Immunology;improved;in vitro Model;Infection;Infectious Agent;Intestinal Mucosa;Knowledge;Location;Maintenance;Memory;Memory B-Lymphocyte;Methods;Modeling;Modification;Molecular;Mucosal Immunity;Mucous Membrane;Natural Immunity;non-typhoidal Salmonella;novel;Oral;Organism;Organoids;Participant;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Play;Population;programs;Regulatory T-Lymphocyte;Research Project Grants;response;Role;Salmonella;Salmonella typhi;Salmonella typhimurium;Salmonella Vaccines;Scientist;Serotyping;Shigella;Shigella flexneri;Shigella Infections;Shigella Vaccines;single-cell RNA sequencing;Site;Specimen;stemness;Suspensions;synergism;System;T-Lymphocyte;Techniques;Technology;Tissues;tool;Transcriptional Activation;transcriptome sequencing;transcriptomics;Typhoid Fever;Vaccination;vaccine candidate;vaccine development;Vaccines

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 AM-I (J1)]


NIH_SPENDING_CATS: Digestive Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PROJECT_TERMS: Adult;Award;Baltimore;Child;Collaborations;collaborative environment;Communication;Contracts;data management;data sharing;Doctor of Medicine;Enteral;enteric pathogen;experience;Fostering;global health;Goals;Grant;Human;Immunity;Immunology;Infection;Institution;Intellectual Property;Lead;Maryland;Monitor;Mucous Membrane;Office of Administrative Management;operation;Principal Investigator;Productivity;programs;Progress Reports;Research;Research Personnel;Research Project Grants;Resources;Site;synergism;timeline;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Vaccination;vaccine development;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Patient Safety;Prevention;Vaccine Related

PI_NAMEs: CHEN, WILBUR H. (contact)

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Biological Specimen Banks;Biometry;Biopsy;Biopsy Specimen;Blood;Blood donor;Businesses;Child;Clinic;Clinical;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;clinically relevant;Collection;Colonoscopy;Communication;Consent;Cytometry;Data Analyses;data sharing;Databases;Distal part of ileum;Documentation;Duodenum;Eligibility Determination;Endoscopy;Ensure;enteric pathogen;Esophagogastroduodenoscopy;experience;Faculty;Future;Goals;Good Clinical Practice;Guidelines;Health Insurance Portability and Accountability Act;Human;human subject protection;Human Subject Research;Image;Immunity;Immunization;Immunologics;Individual;Infection;Informed Consent;Infrastructure;Institutional Review Boards;Intervention;Intestinal Mucosa;Label;Leadership;Legal;Licensing;Maryland;Medical;Medical center;medical schools;meetings;Methods;Monitor;Mucous Membrane;National Institute of Allergy and Infectious Disease;non-typhoidal Salmonella;Nurses;Oral;Patient Care;Patients;Physicians;Policies;Procedures;Process;Protocols documentation;Quality Control;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Salmonella typhi;Schedule;Scientist;Shigella;Specific qualifier value;Specimen;Standardization;Systems Biology;Time;Training;Ty21a typhoid vaccine;Typhoid Vaccine;Universities;unvaccinated;Vaccinated;Vaccination;Vaccinee;Vaccines;volunteer

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: FORST, CHRISTIAN  (contact)

PROJECT_TERMS: Acceleration;Adjuvant;Adult;Antibody Repertoire;Attenuated;Automobile Driving;B-Lymphocytes;Bacteria;Bacterial Infections;Bioinformatics;Biological Process;Biometry;Biostatistics Core;cell type;Cells;Child;Clinical;Clinical Data;Communities;Complex;complex data;Cytometry;Data;Data Analyses;data integration;Data Set;data sharing;Development;Ensure;Enteral;enteric pathogen;Enterobacteriaceae;Epigenetic Process;epigenomics;experimental analysis;Experimental Designs;experimental study;Exposure to;Genes;Goals;high dimensionality;Human;Image;Immune response;Immunity;Immunologic Adjuvants;Immunologics;Immunomodulators;improved;Infection;Interest Group;Knowledge;Leadership;Maps;Methods;Modeling;Molecular;Molecular Profiling;molecular scale;Mucosal Immune Responses;Mucous Membrane;multi-scale modeling;multidimensional data;Multiomic Data;multiple omics;Natural Immunity;network models;Network-based;novel;Organoids;Outcome;outcome prediction;Participant;pathogen;pathogenic bacteria;Pathway Analysis;Pathway interactions;Performance;Procedures;programs;Property;Protocols documentation;Research;Research Design;Research Personnel;Research Project Grants;Research Support;response;Services;Severity of illness;Signal Pathway;Statistical Methods;Structure;success;System;Systems Biology;T-Lymphocyte;transcriptomics;Vaccination;vaccine immunogenicity;Vaccines;Validation;Variant

PROJECT_TITLE: Systems Biology and Biostatistics Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: HO, WON JIN  (contact)

PROJECT_TERMS: Acceleration;Adult;Antibodies;B-Lymphocytes;Bacteria;Biological Assay;Biopsy;Biopsy Specimen;Biostatistics Core;cell type;Cells;Child;Clinical;clinical infrastructure;Color;Computer software;Custom;Cytometry;Data;data management;data modalities;Data Set;data sharing;Dissociation;Ensure;Enteral;enteric pathogen;Epigenetic Process;epigenomics;Evaluation;experience;Exposure to;global health;Goals;Grant;Gut Mucosa;high dimensionality;Histologic;Human;Image;imaging Segmentation;Immune;Immune response;Immune system;Immunity;Immunohistochemistry;Immunologics;Immunologist;Immunology;improved;In Situ;Individual;Infection;Infrastructure;insight;instrument;interest;Lead;Leadership;Location;Maryland;Methodology;Methods;Molecular;Molecular Analysis;Mucosal Immune Responses;Mucous Membrane;operation;pathogen;pathogenic bacteria;Pathologist;Performance;peripheral blood;Phenotype;Physicians;Process;Proteins;Protocols documentation;public repository;Research;Research Personnel;Research Project Grants;Research Support;Resolution;response;Salmonella typhi;Sampling;Scientist;Secure;Services;Shigella;spatial integration;spatial relationship;Stains;success;synergism;Systems Biology;T-Lymphocyte;Techniques;Tissues;Titrations;Training;transcriptomics;tumor-immune system interactions;Universities;Vaccination;vaccine development;Vaccines;Validation

PROJECT_TITLE: Imaging Mass Cytometry Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Human Genome;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related

PROJECT_TERMS: Address;Adult;Affect;Africa South of the Sahara;antigen-specific T cells;Antigens;Architecture;ATAC-seq;Attenuated;B-Lymphocytes;Biopsy;Cells;Cellular Immunity;Characteristics;Child;Clinical;Clinical Research;combat;Conjugate Vaccines;Cytometry;Data;design;Developing Countries;Development;Disease;Distal part of ileum;Duodenum;effector T cell;Enteral;enteric pathogen;Epigenetic Process;Exposure to;Future;Generations;Genomic approach;Goals;Gut Mucosa;Health;Helper-Inducer T-Lymphocyte;Homing;Human;Image;Immune;Immune response;Immunity;Immunization;Immunize;Immunologics;Infection;Intestines;Knowledge;Licensing;Location;Maintenance;Memory;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;Mucosal Immunity;Mucous Membrane;novel vaccines;Oral;Outcome;Participant;pathogen;pathogenic bacteria;Pathway interactions;Play;Population;Publishing;Regulatory T-Lymphocyte;response;Role;Route;Salmonella;Salmonella infections;Salmonella typhi;Salmonella typhimurium;Serotyping;Shigella;Shigella Infections;Shigella Vaccines;single-cell RNA sequencing;Site;Specimen;stemness;Systems Biology;T memory cell;T-Lymphocyte;T-Lymphocyte Subsets;Technology;Testing;Tissues;transcriptome sequencing;transcriptomics;Ty21a typhoid vaccine;Typhoid Fever;Typhoid Vaccine;Vaccinated;Vaccination;vaccine access;Vaccine Design;Vaccines;volunteer;Work;young adult

PROJECT_TITLE: Mechanisms of Induction and Maintenance of Systemic and Gut Mucosal T Cell Immunity to Salmonella and Shigella Following Infection and Vaccination in Children and Adults


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: TOAPANTA, FRANKLIN R. (contact)

PROJECT_TERMS: Adult;Affect;age group;age related;Antigens;Architecture;Attenuated Vaccines;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Bacteria;bacterial resistance;Biopsy;Biostatistics Core;CD4 Positive T Lymphocytes;CD8B1 gene;Cells;Characteristics;Child;Collaborations;Conjugate Vaccines;Cytometry;Data;data integration;Data Set;Developing Countries;Development;Disease;Distal part of ileum;Enteral;enteric pathogen;Epigenetic Process;epigenome;extensive drug resistance;Flow Cytometry;Funding;Gene Expression;Genomics;Goals;Gut Mucosa;Human;Image;Immune;Immunity;Immunization;Immunize;Immunoglobulin A;Immunologics;improved;Individual;Infection;Location;Measures;Memory B-Lymphocyte;Methods;Modeling;Mucosal Immunity;Mucous Membrane;Natural Immunity;novel;novel vaccines;Oral;oral vaccine;pathogen;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Predisposition;Primary Infection;Public Health;Reagent;Research Project Grants;resistant Shigella;response;Salmonella;Salmonella infections;Salmonella typhi;Salmonella Vaccines;Shigella;Shigella flexneri;Shigella Infections;Specimen;Systems Biology;Testing;tissue resident memory T cell;Tissues;transcriptome;transcriptome sequencing;Ty21a typhoid vaccine;Vaccinated;Vaccination;Vaccine Design;Vaccinee;Vaccines;volunteer

PROJECT_TITLE: Immune Mechanisms Regulating the Development of Systemic and Mucosal Antigen-specific B Cells After Vaccination and Challenge in Humans


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Digestive Diseases;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

PI_NAMEs: MEZGHANNI, ROSANGELA  (contact)

PROJECT_TERMS: Address;Adjuvant;Adjuvanticity;Adult;Affect;Animal Model;Antigens;Bacteria;Bacterial Infections;Cell Separation;cell type;Cells;Cellular Structures;Child;Chromatin;chromatin modification;Clinical;Collaborations;Colon;combat;Complement;cytokine;Cytometry;Cytotoxic T-Lymphocytes;D Cells;Development;differential expression;Distal part of ileum;DNA Sequence Alteration;Duodenum;enteric pathogen;Environment;Epigenetic Process;epigenome;Epithelial Cells;Epithelium;Exhibits;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Heritability;Human;Image;Immune response;Immune system;Immunity;Immunization;Immunize;Immunologic Memory;improved;In Vitro;in vivo;in vivo Model;Individual;Infection;insight;intestinal epithelium;Intestinal Mucosa;Intestines;Lead;Maps;migration;Modeling;Modification;Mucous Membrane;Natural Killer Cells;novel;Oral;oral vaccine;Organoids;pathogen;Pattern;peripheral blood;pharmacologic;Phenotype;placebo group;Play;programs;Reader;Research Project Grants;Resistance;response;Role;Salmonella typhi;Sampling;Shigella flexneri;Signal Pathway;Signal Transduction;small molecule;Specimen;Stimulus;System;Systems Biology;T-Cell Receptor;T-Lymphocyte;Testing;Tissues;tool;Training;Ty21a typhoid vaccine;Typhoid Fever;Vaccination;vaccination outcome;vaccine development;Vaccines;Work

PROJECT_TITLE: Role of Epigenetics and their Pharmacological Modulators in Innate Intestinal Immunity and Adjuvanticity in Humans


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Relevance to Public Health Due to its significant involvement in biological processes, cell migration contributes to disease progression in cancer and arthritis, while its impairment leads to anomalous tissue development or regeneration. Our approach of combining genetic resources with live-cell imaging and optogenetic operations will uniquely dissect the molecular mechanisms of cell migration, and may offer novel mechanistic insights into the cell migration-related diseases.

PI_NAMEs: SAEZ GONZALEZ, CRISTIAN J. (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Acetylation;Acetyltransferase;Actins;Actomyosin;Affect;alpha Tubulin;Arthritis;Axon;Back;Biological Process;biophysical properties;Biophysics;cell motility;Cell Physiology;Cell Polarity;cell type;Cells;Cellular biology;Cellular Morphology;Characteristics;Cilia;comparison control;Cytoskeleton;Data;Defect;Destinations;Development;Disease;Disease Progression;Elements;Embryo;Embryonic Development;Environment;Event;Exhibits;Extracellular Matrix;F-Actin;Family;Fibroblasts;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Focal Adhesions;Future;Generations;Genetic;genetic resource;Guanosine Triphosphate Phosphohydrolases;Immune response;Impairment;indexing;insight;Knock-out;Knockout Mice;live cell imaging;Malignant Neoplasms;Measures;Mediator;Membrane Lipids;Membrane Proteins;Microfilaments;Microtubules;migration;Migration Assay;Molecular;Monitor;Morphology;Motility;Motor;Movement;Multiprotein Complexes;Myosin ATPase;Natural regeneration;Neoplasm Metastasis;Neurons;novel;operation;optogenetics;Out-Migrations;Pathogenesis;pharmacologic;Phenotype;Physiological;Physiological Processes;Play;polarized cell;polymerization;Polymers;Post-Translational Protein Processing;Property;Proteins;Public Health;Reaction;Regulation;Resources;rho;rho GTP-Binding Proteins;Role;sensor;Shapes;synthetic biology;Testing;Time;Tissues;tool;Traction;Traction Force Microscopy;two-dimensional;Vinculin;Visualization;wound closure;wound healing

PROJECT_TITLE: The role of acetylated microtubules in cell migration


NIH_SPENDING_CATS: Cancer

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Covalent protein modifications are critical regulatory signals that enable cells to adapt to changing conditions, but they are often dysregulated in diseases, such as cancer. In the interest of improving public health, we must understand–at the molecular level–how such modifications affect protein function and dysfunction. To this end, the proposed work will establish a causative link between protein modification, structure, and function, which may ultimately translate to new treatment strategies for human diseases.

PI_NAMEs: USHER, EMERY THOMAS (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Advanced Development;Affect;Agreement;Amino Acids;Behavior;Binding;biophysical properties;Biophysics;C-terminal;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;cell growth regulation;Cell Physiology;Cell Proliferation;Cells;Chemicals;Data;Dependence;Development;Disease;Dissociation;E2F transcription factors;Electrostatics;Epitopes;Etiology;Eukaryotic Cell;Event;Excision;experimental study;Fluorescence;Fostering;Functional disorder;functional outcomes;Future Generations;G1/S Transition;Generations;genetic regulatory protein;human disease;improved;Infrastructure;insight;interest;intermolecular interaction;Link;Malignant Neoplasms;Maps;Methods;Mission;Modeling;Modification;Molecular;Molecular Conformation;Neurodegenerative Disorders;NMR Spectroscopy;novel therapeutic intervention;Phosphorylation;Phosphorylation Site;Phosphoserine;Phosphothreonine;Post-Translational Protein Processing;Process;Property;Protein Conformation;protein folding;protein function;Protein Region;Proteins;Public Health;Publishing;Radial;Regulation;Reporting;Research;Research Personnel;response;Retinoblastoma Protein;Roentgen Rays;Role;Science;Signal Transduction;simulation;single molecule;single-molecule FRET;Structure;Surface;System;Testing;therapeutic development;Training;Transcriptional Regulation;Translating;Tumor Suppressor Proteins;United States National Institutes of Health;Work

PROJECT_TITLE: CONTROL OF RB TUMOR SUPPRESSOR FUNCTIONS THROUGH POST-TRANSLATIONAL MODIFICATIONS

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


NIH_SPENDING_CATS: Neurosciences

PHR: Project Narrative Recent work has uncovered incredible transcriptional diversity within the somatostatin cortical interneuron class. Although much work has shown that interneuron circuit integration drives the proper maturation of cortex, the precise efferent connectivity of cortical interneurons subtypes, and how this precision is achieved in development, is unknown. This project seeks to link transcriptional diversity of somatostatin subtype specific functional connectivity in cortical microcircuits, to examine how this specify arises in development and to explore the role of developmental activity in this process.

PI_NAMEs: HAIRSTON, ARIEL  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TITLE: Activity-Dependent Circuit Integration of Somatostatin Interneuron Subtypes in the Developing Neocortex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative  Liver fibrosis is the consequence of chronic liver diseases, such as hepatitis B and C infection and alcoholic and non-alcoholic steatohepatitis, and to date, there is no effective anti-fibrotic agent for treating liver cirrhosis, thus, effective treatments for liver fibrosis and cirrhosis are desperately needed. The invasion of hepatic stellate cells (HSCs) to liver parenchyma is crucial for fibrosis development and we found that Wilms tumor 1 (WT1) is upregulated in migrated and invaded HSCs. Because the role of WT1 in the HSC invasive phenotype of HSCs is not fully understood, we will investigate the role of WT1 and its downstream effector pathways in HSC migration, invasion and extracellular matrix production, developing bridging fibrosis.

PI_NAMEs: SEKI, EKIHIRO  (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Alcoholic steatohepatitis;antifibrotic treatment;Architecture;bile duct;Binding;Binding Sites;Biological Assay;Carbon Tetrachloride;carboxypeptidase C;cathepsin K;cell motility;Cellular biology;Cholestasis;chronic liver disease;Cicatrix;Cirrhosis;Collagen;collagenase;Data;Development;Digestion;digital;effective therapy;Elements;Environment;Enzymes;Exhibits;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Fibrosis;HAS2 gene;Hepatic;Hepatic Stellate Cell;Hepatitis B;Hepatitis C;Heterogeneity;Human;Hyaluronic Acid;Hypoxia;improved;In Vitro;in vivo;Infection;inhibitor;Invaded;Knock-out;Knockout Mice;Life;Ligation;Liver;Liver Cirrhosis;liver development;Liver Failure;Liver Fibrosis;liver hypoxia;Liver parenchyma;Mediating;migration;Modeling;Molecular;Mus;nonalcoholic steatohepatitis;Pathway interactions;Phenotype;Population;Portal Hypertension;Primary carcinoma of the liver cells;Process;Production;Promoter Regions;Role;single-cell RNA sequencing;Specimen;stellate cell;Testing;therapeutic target;Thioacetamide;Toxin;transcription factor;transcriptome sequencing;transcriptomics;WT1 gene

PROJECT_TITLE: Determination of Molecular Mechanism of Stellate Cell-Mediated Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 KUDS-Y (04)]


ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project narrative In the United States, 1.84 million people have type 1 diabetes with 21% increase in diagnosis between 2001 and 2009, and 5 million people expected to be diagnosed by 2050. Islet transplantation can cure type 1 diabetes, but it requires chronic systemic immunosuppression which limits the applicability of this procedure only to the most severe cases of type 1 diabetes. Our innovative platform for islet microencapsulation through conformal coating combined with our localized immunomodulatory approaches may eliminate the need for lifelong systemic immunosuppression and extend the applicability of islet transplantation to a larger number of patients with type 1 diabetes.

PI_NAMEs: TOMEI, ALICE  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Affect;Alloantigen;Allogenic;Allografting;anergy;Animal Model;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Biocompatible Materials;biomaterial compatibility;Calcineurin inhibitor;capsule;Chronic;Clinical;clinical application;clinical translation;Combined Modality Therapy;Dependence;design;diabetic;Diagnosis;Diameter;Drug Targeting;Encapsulated;Funding;Glucose;Human;humanized mouse;Hydrogels;immune modulating agents;immunomodulatory therapies;immunoregulation;Immunosuppression;improved;In Vitro;in vivo;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interferon Type II;intrahepatic;islet;islet allograft;Islets of Langerhans Transplantation;Luciferases;lymph nodes;Metabolic Control;meter;Modeling;mouse model;Mus;nanofiber;nanomaterials;nanomicelles;nanovesicle;nonhuman primate;Omentum;Patients;Performance;Permeability;Persons;Pharmaceutical Preparations;Physiological;Polyethylene Glycols;pre-clinical;preconditioning;prevent;Procedures;Protocols documentation;Quality of life;Rattus;Recurrence;Regimen;Regulation;Safety;serial imaging;side effect;Site;Source;stem cells;Steroids;Stromal Cells;Structure of beta Cell of islet;subcutaneous;Supplementation;synergism;T-Cell Activation;T-Lymphocyte;Testing;Thick;Transplantation;United States;Vascularization;Work

PROJECT_TITLE: Conformal islet encapsulation for transplantation at vascularized sites to allow physiological insulin secretion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (83)]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative New antibiotics are urgently needed as pathogens become increasingly drug-resistant, and an attractive set of targets are the bacterial machines involved in cell wall growth. In Escherichia coli, there are two major cell wall synthesizing complexes: the Rod system involved in cell elongation, and the divisome responsible for cell division. My project will investigate the function of the RodZ protein that is important for the activity of the rod system, and the insights gained have the potential to identify new vulnerabilities in bacterial surface growth to target for antibiotic development.

PI_NAMEs: SUAREZ, KATHERINE AIMEE (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: analog;Antibiotics;Binding;Biochemical;Biogenesis;Biological Assay;Bypass;C-terminal;Cell division;cell envelope;Cell Shape;Cell Wall;Cells;Complex;Cytolysis;Development;Drug resistance;Escherichia coli;Escherichia coli Proteins;experimental study;Family;fluorescence imaging;Genetic;Growth;High temperature of physical object;Homologous Gene;Hyperactivity;insight;Label;Lateral;Mediating;Membrane Proteins;Modeling;Multiprotein Complexes;mutant;Mutation;Mutation Analysis;Osmosis;pathogen;Penicillin-Binding Proteins;Peptides;Peptidoglycan;periplasm;Phenotype;Physiological;Play;Polymerase;Polysaccharides;prevent;Production;protein crosslink;Proteins;Rod;Role;Sedimentation process;Shapes;Site;Site-Directed Mutagenesis;Sodium Chloride;Stress;Structure;Surface;System;Testing;transposon sequencing;Variant

PROJECT_TITLE: Elucidating the Function of the Periplasmic Domain of Shape-Determining E. coli Protein RodZ

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Prevention;Wound Healing and Care

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Although evidence indicates that half of all surgical site infections may be preventable, they are on the rise in the United States and are a substantial cause of morbidity, prolonged hospitalization, mortality, and healthcare costs. There is a lack of evidence-based guidelines for pediatric surgical infection risk factors and prevention protocols leading to high variability and low reliability across pediatric surgical care settings. This study aims to apply machine learning to generate prediction models using electronic health data that will inform the design of a clinical decision support tool prototype that provides clinicians with precision pediatric infection risk estimations and prevention recommendations.

PI_NAMEs: CHAN, CARRIE  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: 18 year old;Adult;Artificial Intelligence;Calibration;California;career;Caring;Child;Child Health;Childhood;Clinical;clinical care;clinical decision support;clinical decision-making;Clinical Informatics;cost;Data;Data Science;Data Set;Data Sources;Databases;Decision Making;design;Discrimination;disorder prevention;Early Diagnosis;electronic health data;Electronic Health Record;Environment;Epidemiologic Methods;Evaluation;evaluation/testing;evidence base;evidence based guidelines;experience;faculty research;Family;Feedback;Focus Groups;Future;Goals;Health;Health Care Costs;health care quality;Health Promotion;Healthcare Systems;high dimensionality;Hospitalization;human centered design;improved;Individual;Infection;Infection prevention;infection risk;Informed Consent;Infrastructure;iterative design;Lead;Learning;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Medicine;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Nurse Practitioners;Operative Surgical Procedures;Patient Care;Patient-Focused Outcomes;Patients;Pediatric Nursing;pediatric patients;Pediatric Surgical Procedures;Pediatrics;Performance;personalized care;point of care;Postdoctoral Fellow;Precision Health;precision medicine;predictive modeling;prevent;Prevention;Prevention Protocols;Preventive care;Process;programs;prospective test;Protocols documentation;prototype;Public Health Informatics;Recommendation;Research;Research Personnel;Risk Estimate;Risk Factors;risk prediction;risk prediction model;Safety;Sample Size;San Francisco;shared decision making;skills;statistical and machine learning;Statistical Methods;statistics;support tools;surgery outcome;surgical risk;Surgical Wound Infection;technology validation;Testing;Time;tool;Training;training data;trend;United States;Universities;usability

PROJECT_TITLE: PreoP-SSI: Prediction and prevention of pediatric surgical site infections