ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: A new tPA nanoconjugate is being investigated as an effective and safe treatment for stroke. It could benefit more stroke patients than can be treated with tPA alone because of the extended window of treatment and reduced risk of hemorrhagic complications.

PI_NAMEs: LABHASETWAR, VINOD D (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;Alteplase;angiogenesis;Animals;antioxidant enzyme;Binding;Blood;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Brain hemorrhage;Brain Infarction;brain repair;brain tissue;Carotid Arteries;catalase;Cause of Death;Cerebrovascular Circulation;Characteristics;Clinical;Coagulation Process;Cytolysis;Data;design;Development;disability;Dose;economic cost;Edema;effective therapy;Elderly;Encapsulated;endovascular thrombectomy;Environment;enzyme activity;Event;Extravasation;FDA approved;Fibrinolytic Agents;Formulation;Goals;Half-Life;Heart;Hemorrhage;improved;In Vitro;in vivo;Infarction;Inflammation;Inflammatory;Injections;Intravenous;intravenous administration;intravenous injection;Ischemia;ischemic injury;Ischemic Stroke;Kidney;Long term disability;Lung;Mediating;Mediator;Memory;migration;Mitochondria;Modeling;Morbidity - disease rate;Motor;Movement;nano;Nanoconjugate;nanoparticle;Natural regeneration;neurogenesis;Neurologic;neurological recovery;neuron apoptosis;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;Organ;Oxidative Stress;Phase;Play;post stroke;prevent;Process;protective effect;Rattus;Reactive Oxygen Species;Recovery;Recovery of Function;repaired;Reperfusion Injury;Reperfusion Therapy;response;Risk;Role;Sequential Treatment;Signal Transduction;Slice;socioeconomics;stem cells;Stroke;stroke model;stroke patient;stroke therapy;Superoxide Dismutase;Survival Rate;Symptoms;Tail;Temperature;Testing;Therapeutic Agents;thromboembolic stroke;Thromboembolism;thrombolysis;Thrombus;Time;translational potential;treatment risk;Veins

PROJECT_TITLE: tPA nanoconjugate for stroke therapy

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Nanotechnology;Wound Healing and Care

ORG_CITY: FAIRFAX

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: GEORGE MASON UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE We will design self-propelled urease-fueled DNA origami-based nanoparticles (DNA-SPPs) that can disrupt the topical biofilm matrix and deliver antibiotics in most acidic regions of the biofilms for efficient bacteria killing. Aim 1 will optimize the enzymatic propulsion mechanism for directed locomotion in different urea and pH distributions, while Aims 2 and 3 will respectively demonstrate the efficacy of DNA-SPP-mediated degradation of the biofilm matrix and DNA-SPP-powered delivery of antibiotics to kill bacteria.

PI_NAMEs: MORAN, JEFFREY LAWRENCE (contact);VENEZIANO, REMI

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TERMS: Acidic Region;Anti-Bacterial Agents;anti-microbial drug;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antigens;Area;Bacteria;Biological;Biological Assay;Biomass;biomaterial compatibility;Bladder;Burn injury;Bypass;Ceftazidime;Cessation of life;Chemotaxis;Clinical;Clinical Trials;combinatorial;Complex;Data Set;Dependence;design;Destinations;diabetic ulcer;Diameter;Disease;DNA;DNA Maintenance;Economics;Environment;Enzymes;extracellular;Extracellular Matrix;fabrication;Fibroblasts;Fluorescence Spectroscopy;Foundations;Future;Gastrointestinal Diseases;Gel;Health Care Costs;Human;Hydrogen Peroxide;Hydrolase;Immune response;in vivo;Infection;innovation;Location;Locomotion;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Measures;Mediating;Medical Care Costs;Methods;Microbial Biofilms;Microbiology;model organism;Modeling;mouse model;Mucins;multidisciplinary;Mus;nanoparticle;nanoscale;Nanotechnology;Nutrient;open wound;Output;particle;pathogen;Patients;Pattern;Penetration;Permeability;pH gradient;Pharmaceutical Preparations;Platinum;Polymers;Predisposition;Pseudomonas aeruginosa;quorum sensing;remediation;response;Shapes;Skin;skin lesion;Speed;spheroids;Stomach;Stress;success;targeted delivery;technology platform;Testing;Topical application;Transmission Electron Microscopy;Uncertainty;Urea;Urease;Urine;Work

PROJECT_TITLE: Enzyme-Powered Self-Propelled DNA Nanoparticles for Disruption and Antibiotic Delivery in Topical Biofilms

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: Project narrative Outcomes of this study will provide data-driven evidence to improve novel vaccine candidates and vaccination strategies aimed at inducing protective immune responses against tuberculosis. The study focuses on a novel indication for a licensed product, the BCG vaccine, which is not currently administered to adolescents in countries with high tuberculosis burden. A realistic estimate of vaccine efficacy and duration of protection in susceptible populations are the main determinants to evaluate the public health impact and cost-effectiveness of such intervention.

PI_NAMEs: NEMES, ELISA  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: adaptive immune response;Adolescent;Antibodies;Antimicrobial Resistance;arm;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;Biological Assay;Blood;Blood specimen;Cells;Cessation of life;Clinical Trials;cohort;Collection;confirmatory trial;Containment;cost effectiveness;Country;Cytometry;Data;Development;Disease;efficacy evaluation;efficacy testing;efficacy trial;Epidemic;experience;Flow Cytometry;follow-up;Genus Mycobacterium;high risk population;HIV;Immune;Immune response;Immune system;Immunoglobulin A;Immunologics;improved;Individual;Infection;Infectious Agent;Innate Immune Response;Interleukin-10;Intervention;Lavage;Licensing;Liquid substance;Longevity;Lung;Lung immune response;Macaca mulatta;Measures;Mediating;Mycobacterium tuberculosis;Myelogenous;novel;novel vaccines;Outcome;Outcome Study;Participant;participant enrollment;peripheral blood;Phase;Placebos;Population;Predisposition;prevent;Prevention;Primary Infection;Proteomics;Public Health;research clinical testing;response;Risk;Sampling;Serology;Signal Transduction;Site;Specimen;System;Technology;Testing;Time;Tuberculosis;Tuberculosis Vaccines;Vaccination;vaccination against tuberculosis;vaccination strategy;vaccine candidate;vaccine efficacy;vaccine immunogenicity;vaccine response;vaccine trial;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Durability of systemic and lung immune correlates of BCG-induced protection against M. tuberculosis infection

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: Lack of social connection—especially loneliness—is a common and powerful contributor to suicidal ideation, suicide attempts, functional decline, and even death. The COVID-19 pandemic and its long aftermath amplify risk for loneliness, health problems, and suicide as well as other causes of mortality. A population of particular concern is older adults and patients with medical or psychiatric problems who have limited engagement in treatment. Caring Contacts is an evidence-based suicide prevention intervention that can potentially help. In this project, we will conduct a clinical trial of an adaptation of Caring Contacts tailored to older Veterans who miss their VA healthcare appointments. This project will help advance scientific understanding of how, and in what ways, Caring Contacts works. It will also evaluate a timely, pragmatic, low-cost, and scalable intervention with applicability to post-pandemic treatment engagement and future disasters.

PI_NAMEs: TEO, ALAN  (contact)

PROJECT_TERMS: acceptability and feasibility;Acute;Address;Affect;Age;Aging;Ambulatory Care;Appointment;Area;arm;care outcomes;Caring;Cessation of life;Clinical;Clinical Trials;comparison control;Control Groups;cost;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;dashboard;Data;Diagnosis;Disasters;effectiveness evaluation;evidence base;experience;Feeling suicidal;follow-up;functional decline;Funding;Future;future implementation;Gender;Grant;Health;Health Resources;Health Services;Health Services Accessibility;Health Services Research;Health system;Healthcare;Individual;innovation;Intervention;intervention refinement;Loneliness;Medical;Mental Health;Mental Health Services;Methodology;mortality;Nonpharmacologic Therapy;novel;older adult;older patient;Outcome;Outpatients;outreach;Overdose;pandemic disease;patient population;Patient Self-Report;Patients;peer;peer support;Pharmaceutical Preparations;Population;post-pandemic;pragmatic trial;Prevention strategy;preventive intervention;primary care visit;psychiatric comorbidity;Randomized, Controlled Trials;recruit;research and development;Resources;response;Risk;Scientific Advances and Accomplishments;Site;social;social health determinants;Social isolation;Social support;sociodemographics;Socioeconomic Status;Specialist;Suicide;Suicide attempt;Suicide prevention;suicide rate;Survival Analysis;Testing;Time;treatment arm;treatment as usual;treatment response;Trust;usual care arm;Veterans;whole health;Work

PROJECT_TITLE: Increasing Social Connection Through Crisis Caring Contacts: A Pragmatic Trial

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Recent stroke trials have shown that with the help of imaging, late thrombectomy is beneficial. We propose to further the development of pH and diffusion kurtosis imaging for improved ischemic tissue characterization. We will test the refined mismatch paradigm using permanent and transient middle cerebral artery occlusion (MCAO) rats, laying the foundation for future clinical translation.

PI_NAMEs: SUN, PHILLIP ZHE (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Acute;acute stroke;Address;Age;aged;American Heart Association;Amides;Benign;Clinic;Clinical;clinical decision-making;clinical translation;Clinical Trials;comorbidity;Complement;Development;Diabetes Mellitus;diabetic;diabetic rat;Diffusion;Diffusion Magnetic Resonance Imaging;effectiveness testing;Eligibility Determination;Evolution;Filament;follow-up;Foundations;Funding;Future;Guidelines;Histology;Image;image guided;Imaging Techniques;improved;Investigational Therapies;Ischemia;ischemic injury;Ischemic Stroke;Lesion;Magnetic Resonance Imaging;Maps;Mechanics;Metabolic;Middle Cerebral Artery Occlusion;Modeling;Monitor;Morphologic artifacts;National Institute of Neurological Disorders and Stroke;neuroimaging;Outcome;Outcome Assessment;Patients;Pattern;Perfusion;Predictive Value;prospective;Protons;Radiology Specialty;Rattus;Relaxation;Reperfusion Therapy;Reporting;Research Personnel;revascularization;severe injury;spatiotemporal;Stroke;stroke model;stroke outcome;stroke patient;stroke therapy;stroke trials;success;Surrogate Markers;T2 weighted imaging;Techniques;Testing;Thrombectomy;Time;tissue injury;Tissues;tool;United States National Institutes of Health;Yin

PROJECT_TITLE: Development of fast penumbral imaging in acute ischemic stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;HIV/AIDS;Infectious Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our aims are to determine the burden of persistent HIV infection using novel Positron Emission Tomography (PET) scanning techniques and to study if PET tracer uptake correlates with blood and tissue measures of HIV persistence. Insights gained by this study has the potential to significantly improve development of novel strategies to eradicate or control HIV-1 infection.

PI_NAMEs: HENRICH, TIMOTHY JENSEN (contact);HSUE, PRISCILLA Y.;VANBROCKLIN, HENRY F.

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Address;Adult;Anatomy;Animal Testing;antiretroviral therapy;Binding;Biopsy Specimen;Blood;Blood specimen;Bone Marrow;Cells;Circulation;cohort;Collaborations;Collection;Data;Development;Enrollment;Feasibility Studies;first-in-human;Funding;Genetic Transcription;Goals;Heterogeneity;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;Human;Image;imaging approach;imaging program;imaging study;ImmunoPET;improved;in vivo;Individual;Infection;Inguinal lymph node group;insight;Interruption;Knowledge;Location;lymph nodes;Lymphoid;Macaca;Magnetic Resonance;Magnetic Resonance Imaging;Measurable;Measures;Methods;Monitor;Monoclonal Antibodies;Noise;novel;novel strategies;Nucleic Acids;Participant;Peripheral;Positron-Emission Tomography;preclinical development;Production;programs;protein expression;Proteins;Protocols documentation;Radiolabeled;Recrudescences;Regional Anatomy;Research;Residual state;Resolution;Sampling;Signal Transduction;SIV;Techniques;Technology;Tissue Sample;Tissues;tool;Tracer;uptake;Viral;Viral Physiology;Viral Proteins;viral rebound;Viremia;Visualization

PROJECT_TITLE: In Vivo PET Imaging of HIV Infection


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Huntington's Disease;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Using a collection of novel monoclonal antibodies raised to structurally-defined species of mutant huntingtin exon1 (mHTTex1), we will characterize the structure and biochemical properties of various mHTTex1 assemblies, map the conformations influencing misfolding, seeding, and oligomerization in vitro, identify and characterize neuroinvasive species in human neurons and determine whether they trigger pathology in mouse models of HD. Moreover, we will examine whether any of the recombinant conformation-specific antibodies secreted in the CNS of HD mice inhibit the amplification of mHTT assemblies, and further validate their therapeutic properties. These studies will fill some of the knowledge gaps in the pathogenesis of HD, introduce novel therapeutic targets, and a collection of well-characterized antibodies and their recombinant versions for diagnostic and therapeutic applications.

PI_NAMEs: KHOSHNAN, ALI  (contact);LANGEN, RALF

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acceleration;adenovirus mediated delivery;Affect;Antibodies;Antibody Therapy;Binding;Biochemical;Biological;Biological Assay;biophysical techniques;Biophysics;Brain;Classification;Collection;conformer;Cryoelectron Microscopy;Development;Diagnostic;diagnostic assay;diagnostic platform;Disease;Disease Progression;Epitopes;Exons;experimental study;extracellular;Human;Huntington Disease;Huntington gene;In Vitro;in vivo;Inherited;Injections;innovation;insight;Intervention;Knowledge;Length;Libraries;Link;Maps;Measures;Methodology;Methods;Modeling;Molecular;Molecular Conformation;Monoclonal Antibodies;monomer;mouse model;Mus;mutant;Nerve Block;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurons;neurotoxic;neurotoxicity;new therapeutic target;novel;Outcome;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;physical state;Physiological;Plasma;polyglutamine;prevent;Production;Property;Proteins;proteostasis;Protocols documentation;Reagent;receptor;Recombinant Antibody;Recombinants;Research;Resolution;Role;Severity of illness;Specimen;Structure;targeted treatment;Testing;Therapeutic;therapeutic target;therapy development;Time;tool;Toxic effect

PROJECT_TITLE: Characterizing the Conformations and Neurotoxic Species of Huntingtin

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pediatric;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The development of protective immunity to influenza is of central importance to public health, yet little is known about how natural infections and vaccinations contribute to the development of protection against diverse influenza strains over time. This research uses observations from a large, longitudinal pediatric cohort to fit mathematical models to explain how protection evolves early in life. The results will contribute to fundamental knowledge of influenza epidemiology and the development of next-generation influenza vaccines.

PI_NAMEs: COBEY, SARAH  (contact);GORDON, AUBREE L

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: adaptive immune response;Address;Advanced Development;Affect;Age;Antibody Response;Antibody titer measurement;Antigens;associated symptom;Avian Influenza;Biological;Birth;Cessation of life;Characteristics;Child;Childhood;cohort;Cohort Studies;Complex;Complication;Computer software;cross immunity;Data;Dependence;Development;Development Plans;diverse data;Effectiveness;Epidemiology;Evolution;Exposure to;flexibility;Formulation;Future;Household;Immune;Immune response;Immunity;Immunologic Memory;imprint;improved;Individual;Infection;infection risk;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus strain;influenza virus vaccine;Knowledge;Life;longitudinal dataset;mathematical model;Mathematics;Measures;Methods;Modeling;next generation;Nicaragua;pathogen;Pattern;Pediatric cohort;Persons;Predisposition;Primary Infection;Public Health;Recording of previous events;Research;respiratory;response;Risk Reduction;Role;Sampling;seasonal influenza;Seasons;Serology;Severities;sex;Shapes;Strategic Planning;success;Symptoms;Techniques;Time;tool;transmission process;United States National Institutes of Health;universal influenza vaccine;Vaccination;Vaccines;Variant;Viral;Virus Diseases;Work

PROJECT_TITLE: Longitudinal dynamics of protection after influenza infection and vaccination

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Pediatric;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHOLOGY

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative Parent-based alcohol interventions (PBI) are an effective strategy for preventing alcohol-related risk during the transition into college; however, our understanding of how well PBIs work to protect against these risks is based on controlled studies that are unlikely to produce the same results in the real-world. The proposed project addresses this limitation by developing and optimizing low-cost PBIs so that they are maximally engaging to parents, appealing to university stakeholders, and effective at preventing and reducing alcohol- related risk under real-world conditions. The overall impact of this research can be tremendous given that the focus is not only only identifying the most effective PBI approach outside of tightly controlled studies, but also on how to improve the adoption of these programs.

PI_NAMEs: LABRIE, JOSEPH W. (contact)

PROGRAM_OFFICER_NAME: BALACHOVA, TATIANA NIKOLAYEVNA

PROJECT_TERMS: Address;Administrator;Adoption;Alcohol consumption;alcohol intervention;alcohol measurement;alcohol prevention;alcohol risk reduction;alcohol use initiation;Alcohols;Characteristics;Child;Child Rearing;cohort;college;Communication;Controlled Study;cost;Coupling;Data;design;digital;Documentation;drinking;Education;effective intervention;effective therapy;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation trial;efficacy evaluation;Electronic Mail;Evaluation;experience;Feedback;financial incentive;Focus Groups;Frequencies;Funding;handbook;Health;high risk drinking;implementation barriers;implementation intervention;improved;Incentives;Instruction;Intervention;intervention effect;Interview;Libraries;Marketing;Mediating;Mediator;Methods;Modeling;Motivation;Multimedia;National Institute on Alcohol Abuse and Alcoholism;Outcome;Parents;permissiveness;personalized normative feedback;Phase;pilot trial;Preparation;prevent;programs;prototype;psychoeducation;Public Health;Published Comment;Recommendation;reduced alcohol use;Reporting;Research;Resources;Risk;Risk Reduction;Sampling;Site;skills;skills training;social media;social norm;student drinking;Students;Surveys;Testing;Time;Translating;treatment as usual;underage drinking;Universities;University resources;university student;willingness;Work

PROJECT_TITLE: Norms re-education to promote engagement in parent-based interventions: A Type 1 implementation-effectiveness trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-E (02)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Machine Learning and Artificial Intelligence;Pediatric

ORG_CITY: FORT COLLINS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Public Health Relevance Statement Intubating newborns for mechanical ventilation is challenging due to their size and delicate nature. Unfortunately, nearly 40% of initial intubation attempts result in accidental misplacement of the endotracheal tube in the esophagus instead of the trachea or incorrectly in the trachea or bronchus, and it is critical to detect such tube misplacement promptly. This proposal combines deep learning Simultaneous Multi Source Electrical Impedance Tomography (EIT)-based confirmation of tube placement with EIT images of lungs being ventilated, resulting in a real-time, closed-loop system for tube placement detection and ventilation imaging.

PI_NAMEs: MUELLER, JENNIFER LYNN (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Accidents;adverse outcome;Algorithms;Bedside Technology;Blinded;Bronchi;carina;Cessation of life;Classification;classification algorithm;Clinical;clinical decision-making;Collaborations;Colorado;convolutional neural network;Data;Databases;deep learning;deep learning algorithm;Detection;electrical impedance tomography;Electrodes;Emergency Situation;endotracheal;Enrollment;Esophagus;Functional Imaging;Goals;Hypoxemia;Image;Imaging Techniques;Infant;Intubation;Ionizing radiation;Left;Life;Lung;lung imaging;lung visualization;Maps;Measures;Mechanical ventilation;models and simulation;Modification;Monitor;Nature;Neonatal Intensive Care Units;neonate;Network-based;Newborn Infant;novel;Observational Study;Operating Rooms;Output;Patients;Pneumothorax;portability;Positioning Attribute;prevent;Probability;prospective;public health relevance;Radiation;real-time images;reconstruction;Research;Roentgen Rays;Saline;Scanning;side effect;skills;Source;Special needs;standard of care;stem;success;System;Techniques;Technology;Time;Trachea;training data;Tube;ultrasound;United States;Universities;ventilation;Visualization;voltage;X-Ray Computed Tomography

PROJECT_TITLE: Real-time noninvasive visualization of endotracheal tube placement and 3D lung monitoring in infants with electrical impedance tomography

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative The ultimate purpose of this research is to investigate what cellular, physical, and biochemical characteristics of the environment provided by the membrane in the Masquelet technique are responsible for the procedure’s success in reconstructing large segmental bone defects via grafting. Our results could save hundreds of thousands of limbs that would otherwise be amputated and improve patient care by refining the procedure and expanding its use. It will also uncover novel bone repair mechanisms that may be applicable to other bone formation scenarios like non-union and fusions.

PI_NAMEs: MCBRIDE-GAGYI, SARAH H (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adjuvant;Adult;Amputation;Amputees;Animals;Autologous;Biochemical;Biological;Biological Assay;Biology;Blood Vessels;Body System;bone;Bone Cements;Bone Regeneration;bone repair;Bone Transplantation;cell type;Cells;Characteristics;Clinical;clinical application;clinical practice;cohort;Communities;cost;Defect;design;diagnostic development;Environment;experimental study;Foreign Bodies;Future;Gene Expression;Generations;Genes;Genetic;Goals;Harvest;healing;Health Care Costs;Histology;Imaging Techniques;Implant;implantation;improved;Infection;Infiltration;Isogenic transplantation;Label;Lead;Limb structure;Location;Malignant Neoplasms;Membrane;microCT;migration;Modeling;mouse model;Mus;Natural regeneration;novel;Operative Surgical Procedures;Osteoblasts;Osteocytes;Osteogenesis;osteogenic;Pathway interactions;Patient Care;patient population;Patients;pediatric patients;Population;Procedures;Process;protein expression;Rattus;Reagent;reconstruction;regenerative;regenerative biology;Regimen;Reporting;Research;Research Design;Roentgen Rays;Role;sample fixation;Structure;success;Techniques;Testing;Therapeutic;tissue regeneration;Tissues;tool;Transgenic Mice;Transgenic Organisms;Trauma

PROJECT_TITLE: Bone Regeneration in a Mouse Model of Masquelet's Induced Membrane Technique

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Machine Learning and Artificial Intelligence;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Narrative: GBM is the most common primary brain tumor in adults, and recurrence is almost inevitable. The TIME model developed in this project will enable early prediction of GBM recurrence and salvage radiotherapy without harming the essential neurological functions. The early intervention for GBM recurrence has the potential to delay tumor growth and prolong patient survival.

PI_NAMEs: YANG, WENSHA  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Adult;aggressive therapy;Algorithms;Anatomy;Attention;Benefits and Risks;Brain;brain parenchyma;Brain Stem;Cancer Patient;cell motility;Cells;chemotherapy;Classification;Clinical;Clinical Trials;Collaborations;Coupling;Data;data acquisition;deep learning model;design;Diagnosis;Disease;Dose;Early Intervention;Excision;experience;follow-up;Future;Geometry;Glioblastoma;Goals;Growth;high risk;improved;Intervention;Intervention Trial;Label;Location;machine learning classifier;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Neoplasms;Manuals;Microscopic;Modeling;Nature;neoplastic cell;Nervous System Physiology;neural network;novel;Operative Surgical Procedures;Optic Nerve;Organ;participant enrollment;Patient imaging;patient response;Patient-Focused Outcomes;Patients;Performance;Prediction of Response to Therapy;predictive modeling;Primary Brain Neoplasms;Primary Neoplasm;Productivity;prospective;Radiation Dose Unit;Radiation therapy;radiological imaging;Radiology Specialty;Recurrence;Recurrent tumor;Research;Research Personnel;Risk;Role;stem cell niche;stem cells;success;Testing;Time;Training;treatment planning;treatment response;trial comparing;tumor;tumor growth;Validation

PROJECT_TITLE: Advanced prediction of GBM recurrence (TIME) for personalized radiotherapy


NIH_SPENDING_CATS: Breast Cancer;Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_DEPT: PATHOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The epithelial-mesenchymal transition (EMT) program endows breast cancer cells with stemness, therapy resistance and metastatic competence. The intermediate filament protein vimentin serves an important biological role in sustaining cells that have undergone EMT, and regulated changes in its phosphorylation status (termed “phospho-malleability”) are critical for its function. The proposed studies aim to link vimentin phospho-malleability uniquely to cancer stem cells and develop strategies to treat metastasis, including increasing sensitivity to commonly used chemotherapeutic drugs.

PI_NAMEs: MANI, SENDURAI AYYAVOO (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 4T1;Affect;Behavior;Biological;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Treatment;cancer cell;Cancer cell line;cancer recurrence;cancer stem cell;cancer survival;Cell Line;Cell Survival;Cells;Characteristics;Chemoresistance;combat;Competence;Cytokeratin;Cytokeratin filaments;Cytoprotection;Cytoskeleton;Data;Endowment;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;experimental study;Fibroblasts;Filament;Human;Hybrids;Impairment;In Vitro;in vivo;inhibitor;innovation;Intermediate Filament Proteins;Intermediate Filaments;Link;Literature;M cell;Malignant Breast Neoplasm;Malignant Epithelial Cell;Mesenchymal;mimetics;Modeling;Mus;Mutate;Neoplasm Metastasis;novel;patient derived xenograft model;patient prognosis;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Phosphorylation Site;Play;prevent;Process;programs;Property;Protein Dephosphorylation;Proteins;Recurrence;Research;Resistance;Role;Sampling;Serine;Signal Pathway;Signal Transduction;Site;stem cell function;stem cells;stemness;Stress;targeted treatment;Testing;Therapeutic;triple-negative invasive breast carcinoma;tumor;tumor xenograft;Up-Regulation;Vimentin;Xenograft procedure

PROJECT_TITLE: Vimentin Phospho-Malleability is Critical for Maintaining Stemness and Metastatic Properties

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Missense-loss of function mutations in TTC7A result in severe infantile-onset congenital diarrhea and intestinal inflammation, with a median survival age of patients with TTC7A disease less than 1 year. To expand our understanding of these patient mutations, we are exploring how TTC7A causes symptoms in an evolving model of epithelial cell development and cellular polarity in primary patient derived organoids. The findings from these studies will be broadly impactful for the developmental biology of the GI tract, congenital enteropathies and inflammatory bowel diseases.

PI_NAMEs: BUGDA GWILT, KATLYNN  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;3-Dimensional;Address;Affect;Age;Apical;apical membrane;Apoptotic;Applications Grants;Architecture;Automobile Driving;basolateral membrane;Biological Assay;Biology;Caco-2 Cells;Cell Line;Cell Maintenance;Cell membrane;Cell Polarity;Cells;Cellular Membrane;Cholera Toxin;Cyst;Defect;Development;Development Polarity;Developmental Biology;Diarrhea;Dimerization;Disease;Endoplasmic Reticulum;Endosomes;Enterocolitis;Enterocytes;Epithelial Cells;Epithelium;Etiology;experimental study;Functional disorder;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Generations;Genes;Gland;Goals;Golgi Apparatus;gut inflammation;Heterozygote;human disease;Image;Immune;Immunoglobulin G;in vivo;infancy;Inflammatory Bowel Diseases;inorganic phosphate;Intestinal Atresia;intestinal epithelium;Intestines;knock-down;Knowledge;Label;Ligands;Light;Lipids;Location;loss of function;loss of function mutation;Maps;Mediating;Membrane;Membrane Proteins;Modeling;Molecular Chaperones;Monitor;monolayer;Movement;mutant;Mutation;neonatal Fc receptor;new technology;novel;Organ;Organoids;Pathology;Pathway interactions;Patients;Phenotype;Phosphatidylinositols;Phosphorylation;Phosphotransferases;polarized cell;Process;Production;protein complex;Proteins;receptor;Recycling;Resolution;Role;scaffold;Scaffolding Protein;SERPINA4 gene;Site;Sorting;Source;Space Perception;spatiotemporal;Specialized Epithelial Cell;Symptoms;Testing;Therapeutic;Tissues;trafficking;Training;transcytosis;Translating

PROJECT_TITLE: The role of TTC7A in apical lumen formation and polarized trafficking in the intestinal epithelium


ORG_CITY: MINNEAPOLIS

ORG_NAME: MINNEAPOLIS VA  MEDICAL CENTER

ORG_STATE: MN

PHR: Effective psychotherapies for depression are available in VA but are underutilized by therapists working in specialty mental health clinics. Reasons for low use have not been empirically investigated. Findings from research on the implementation of evidence-based psychotherapies for other conditions such as PTSD cannot be fully generalized to depression because depression care is organized differently in VA. In this project, we use an explanatory sequential mixed-methods approach to examine contextual and system factors that impact delivery of evidence-based psychotherapies for depression as well as explore the impact of potential therapist- and patient-level factors. Findings will inform an intervention framework that will help our partners and stakeholders in the field to prioritize barriers on which to intervene and identify promising solutions.

PI_NAMEs: ACKLAND, PRINCESS E. (contact)

PROJECT_TERMS: Address;Adjustment Disorders;administrative database;Attitude;Behavior Therapy;burden of illness;care delivery;Caring;chronic pain;Classification;Clinic;clinical implementation;Clinical Practice Guideline;Cognitive Therapy;Coin;Competence;Consultations;Data;Dedications;Depressed mood;Depressive disorder;design;Development;Economic Burden;Effectiveness;Evaluation;evidence base;evidence based guidelines;experience;Feeling suicidal;Goals;Guidelines;Health system;Homogeneously Staining Region;innovation;interpersonal therapy;Intervention;intervention mapping;Interview;Investigation;Leadership;Learning;Major Depressive Disorder;Medical center;medical specialties;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Methodology;Methods;Modeling;multiple data sources;Occupational;Patients;Perception;physical conditioning;Policies;Post-Traumatic Stress Disorders;Process;Program Evaluation;Provider;provider-level barriers;Psychotherapy;Quality of life;Random Allocation;Recommendation;Recurrence;reducing suicide;Research;Resources;Risk Factors;Schedule;Site;Sleep Disorders;Specific qualifier value;statistics;Structure;Substance abuse problem;Suicide;Suicide prevention;System;theories;Training;training data;Training Programs;translational study;Veterans;Visual

PROJECT_TITLE: From Training to Practice: Understanding the Integration of Evidence-Based Psychotherapies for Depression (INTEGRATE)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Patient Safety

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Program Director/Principal Investigator (Last, First, Middle): Culley, Deborah J Narrative: Older surgical patients with cognitive impairment are at high risk for poor outcomes after surgery. This proposal will investigate the relationship between preoperative cognitive impairment and aberrant immune responses in the pathogenesis of postoperative complications. As such the proposal may identify new mechanisms involved in adverse patient outcomes after surgery in this high-risk patient population. OMB No. 0925-0001/0002 (Rev. 03/16 Approved Through 10/31/2018) Page Continuation Format Page

PI_NAMEs: CULLEY, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Address;Age;Age Years;age-related disease;Aging;Biological Assay;Brain;care outcomes;Cell Physiology;Cellular Assay;Clinical;clinical center;Clinical Immunology;Cognition;Cognitive;Communication;Data;Defect;Delirium;differential expression;Disease Marker;Elderly;Elements;Event;extracellular vesicles;Functional disorder;Future;Genes;Goals;high risk;Home;Homeostasis;Human;human old age (65+);IL6 gene;Immune;Immune response;Immune system;Immunologics;Immunology;Impaired cognition;Impairment;improved outcome;In Vitro;Inflammation;Inflammation Mediators;Inflammatory;innovation;Location;Mediating;Mediator;Methods;Modeling;Molecular Profiling;monocyte;Morbidity - disease rate;novel;older patient;Older Population;Operative Surgical Procedures;Outcome;particle;Pathogenesis;Pathogenicity;patient population;patient screening;Patient-Focused Outcomes;Patients;Perioperative Care;Persons;Phagocytes;Plasma;Postoperative Complications;postoperative delirium;Postoperative Period;Predisposition;Principal Investigator;Probability;programs;Recovery;Replacement Arthroplasty;Research;Resolution;response;Risk;Risk Factors;Risk Marker;sensor;Shapes;Signal Transduction;Source;Speed;Spine surgery;surgery outcome;Surgical complication;systemic inflammatory response;Technology;Testing;Therapeutic;therapeutic target;Time;tissue trauma;transcriptome;transcriptomics;young adult

PROJECT_TITLE: Cognition and the immunology of postoperative outcomes

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative: Dengue, Chikungunya, Zika and other mosquito-borne diseases continue to pose a major global health burden through much of the world, despite the widespread distribution of insecticides and other interventions. Novel strategies have been proposed to control these diseases, including the release of mosquitoes transfected with Wolbachia and engineered with gene drive systems, the safety and efficacy of which critically depends on a detailed understanding of mosquito movement. In this project, we will use genetic data to quantify the fine- scale movement patterns of Aedes aegypti mosquito vectors and explore implications for novel intervention strategies.

PI_NAMEs: MARSHALL, JOHN MACKY (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Aedes;analytical method;Anti-malarials;Breeding;California;chikungunya;Chikungunya virus;Chromosomal translocation;Chromosome Mapping;Collection;coral;cost;Culicidae;Data;Death Rate;Dengue;Dengue Virus;density;Development;disorder control;Ecology;Effectiveness;Engineering;Environmental Wind;Fishes;gene drive system;Genes;Genetic;genetic analysis;genome sequencing;genomic data;global health;Habitats;Homing;Housing;in silico;Individual;innovation;Insecticides;interest;Intervention;Knowledge;land cover;Larva;Location;male;Male Sterility;mating behavior;Methods;Modeling;Mosquito Control;Mosquito-borne infectious disease;Movement;novel;novel strategies;offspring;Parameter Estimation;Parents;Partner in relationship;Pattern;Population;Population Dynamics;Population Replacements;Population Sizes;Protocols documentation;Research;Safety;Sample Size;Sampling;Scheme;Siblings;simulation;Singapore;Site;Speed;Structure;surveillance strategy;System;three dimensional structure;three-dimensional modeling;tool;Transfection;trial design;Tuna;Variant;vector control;vector mosquito;Wolbachia;ZIKA;Zika Virus

PROJECT_TITLE: Understanding mosquito movement and its relevance to control through genetic analysis

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research

ORG_CITY: HERSHEY

ORG_DEPT: ORTHOPEDICS

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative This project will provide an inclusive technical training to cover key facets of the iterative medical device development process, spanning discovery, invention, regulatory decision-making, prototyping, testing and commercialization. The main objective of this training is to improve students’ problem recognition skills, their motivation to propose and validate a solution, and their ability to apply multidisciplinary knowledge. This training opportunity will allow students to apply fundamental knowledge learned from classes to real applications in team-based biomedical device design, and will prepare students for a career in healthcare technology research and development.

PI_NAMEs: HAYES, DANIEL J.;LEWIS, GREGORY STEPHEN (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Area;Biomedical Engineering;career;Clinical;clinical conference;Clinical Research;Clinical Trials;commercialization;Communication;Computer Analysis;Computer Simulation;cost;Creativeness;Data;Decision Making;design;Development;Device Designs;Device or Instrument Development;Devices;Dimensions;Education;Educational Curriculum;Educational workshop;engineering design;Equipment;experience;Experimental Designs;experimental study;Fostering;Future;Goals;Guidelines;Health Technology;Healthcare;Human;Human Resources;ideation;Immersion;improved;Institution;Interdisciplinary Communication;Interview;invention;Knowledge;Leadership;leadership development;Learning;learning strategy;lectures;Link;Medical Device;Motivation;multidisciplinary;Operative Surgical Procedures;Participant;Pathway interactions;peer;peer learning;Phase;Preclinical Testing;preclinical trial;Procedures;Process;Production;programs;prototype;Regulatory Affairs;repaired;Research;research and development;research clinical testing;Research Training;Self Direction;simulation;skills;Social Responsibility;student participation;Students;Technical Expertise;technology research and development;Testing;Thinking;Training;training opportunity;Training Programs;undergraduate education;undergraduate student;United States Food and Drug Administration;Validation;Work

PROJECT_TITLE: Biomedical Engineering Design: Integrating Simulation, Clinical Immersion, and Regulatory Training


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering

ORG_CITY: WASHINGTON

ORG_NAME: UNIVERSITY OF THE DISTRICT OF COLUMBIA

ORG_STATE: DC

PHR: PROJECT NARRATIVE  Despite a burgeoning elderly population (i.e., globally the number of individuals older than 50 years old is projected to increase to 1.2 billion by 2025), there are insufficient clinicians and researchers to meet this demand. Through this NIA MSTEM project (Advancing Diversity in Aging Research through Undergraduate Education at the University of the District of Columbia), we aim to expose, train, and mentor a diverse cadre of underrepresented minority undergraduate students at the University of the District of Columbia, a Historically Black College and University, to become the next generation of researchers and professionals contributing to novel investigations and interventions tied to aging-related issues.

PI_NAMEs: THOMPSON, LARA A (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Active Learning;African American;Age Years;Aging;aging related;Alzheimer's Disease;Area;Awareness;Behavioral Research;Biomedical Engineering;Biomedical Research;Capital;Clinical Research;college;Communication;Communities;community living;Country;Data Analytics;Degree program;design;Development;Devices;District of Columbia;doctoral student;Ecosystem;Education;education research;education resources;Educational Curriculum;Elderly;Engineering;Equilibrium;ethnic diversity;Ethnic Origin;experience;Exposure to;Faculty;falls;Fostering;Funding;Gait;gender diverse;Gerontology;global health;Goals;Graduate Education;Grant;Health;health training;higher education;Historically Black Colleges and Universities;Human Resources;Image;Individual;Infrastructure;innovation;Institution;Intervention;Investigation;Journals;Lead;Medical Students;Mentors;Mentorship;Methodology;Minority;minority undergraduate;Modeling;next generation;novel;Older Population;Oral;Osteoporosis;outreach;peer;Play;Population;Problem Solving;professional students;programs;Public Health;Publications;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Resources;Role;Science;Series;Site;skills;skills training;Societies;student training;Students;symposium;Talents;Training;trend;undergraduate education;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;ward;Washington;Writing

PROJECT_TITLE: NIA MSTEM: Advancing Diversity in Aging Research through Undergraduate Education at the University of the District of Columbia


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Disability Research;Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Physical Activity;Rehabilitation;Telehealth

ORG_CITY: Chicago

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Cognitive impairment, particularly slowed cognitive processing speed (CPS), is prevalent among 67% of the nearly one million American adults living with multiple sclerosis (MS). The proposed Phase-II, randomized controlled trial examines the effect of a highly-developed and refined Internet-delivered physical activity (PA) intervention for yielding immediate and sustained improvements in remotely-assessed CPS among 280 persons with mild MS-related ambulatory disability who demonstrate impaired CPS. The research proposed in this application, if successful, will provide Class I evidence for the efficacy of an Internet-delivered PA intervention as an accessible and translatable approach for rehabilitation of impaired CPS among persons with MS who most need such an intervention.

PI_NAMEs: MOTL, ROBERT WAYNE (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Accelerometer;active control;Adult;American;Anxiety;Attention;attentional control;Behavior Therapy;Behavioral;Blinded;Clinical;clinical practice;Cognitive;cognitive function;cognitive performance;cognitive rehabilitation;comparison intervention;cost;Data;Data Analyses;depressive symptoms;design;Development;Devices;Digit structure;disability;Disabling;Disabling condition;disabling disease;efficacy evaluation;evidence base;exercise intervention;experience;Fatigue;follow-up;Fostering;Functional disorder;Guidelines;Health;Impaired cognition;Impairment;improved;innovation;internet delivery;Intervention;intervention delivery;Investigation;Knowledge;Life Style;Logistic Regressions;Measures;Medical center;Mental Depression;Mission;Modality;Modeling;Multiple Sclerosis;multiple sclerosis patient;Nature;novel;Outcome;Outcome Assessment;Patient Self-Report;Persons;Pharmacotherapy;Phase;Physical activity;physically handicapped;post intervention;primary outcome;processing speed;Productivity;programs;prospective;Public Health;Quality of life;Randomized;Randomized, Controlled Trials;recruit;rehabilitation research;Rehabilitation therapy;remote assessment;remote delivery;Reporting;Research;Resources;restoration;screening;secondary outcome;Single-Blind Study;social contact;Stimulus;Testing;Time;Translations;Travel;Waiting Lists

PROJECT_TITLE: Internet-Delivered Lifestyle Physical Activity Intervention for Cognitive Processing Speed in Multiple Sclerosis

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE COVID-19/SARS-CoV-2 is now a world-wide pandemic threatening humanity, with emerging Variants of Concern threatening the efficacy of drugs and vaccines against it. This project will seek define the limits of the B cell and antibody response directed against the Receptor Binding Domain (RBD) of the Spike protein in their ability to protect against current and future potential variations in the SARS-CoV-2 virus. We will also address the fundamental question if RBD-specific immunity differs whether it is the result of natural infection and vaccination.

PI_NAMEs: KOBIE, JAMES J (contact);MARTINEZ-SOBRIDO, LUIS ;WALTER, MARK R

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Affinity;Alleles;Anti-viral Agents;Antibody Response;Antigens;B-Lymphocytes;Binding;breakthrough infection;Cessation of life;Chimeric Proteins;Classification;cohort;Complex;COVID-19;COVID-19 therapeutics;COVID-19 vaccine;Development;Disease;drug efficacy;Effectiveness;Epitopes;Evolution;expectation;Failure;Future;Grant;Heterogeneity;Human;Humanities;Humoral Immunities;Immune;Immunity;Immunoglobulins;Immunologics;in vitro activity;in vivo;Incidence;Infection;Inhalation;K-18 conjugate;Maintenance;Mediating;Mesocricetus auratus;Monoclonal Antibodies;mouse model;neutralizing antibody;next generation;Ontology;pandemic disease;Patients;Persons;Phase I/II Clinical Trial;Phenotype;Plasma;Population;Predisposition;preservation;pressure;prospective;Proteins;prototype;rational design;receptor binding;Recombinants;Reporting;Resolution;response;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 transmission;SARS-CoV-2 variant;scaffold;Serology;System;Testing;Therapeutic;Transgenic Mice;Vaccination;Vaccinee;Vaccines;Variant;variants of concern;Viral;Virus;Work

PROJECT_TITLE: The origin and future protective activity of SARS-CoV-2 RBD specific neutralizing antibodies


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: ROCHESTER

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) suffer dismal prognosis due to limited treatment options, especially for those with locally advanced pancreatic cancer or metastatic disease. We recently developed an innovative therapy that resulted in compelling and durable responses in preclinical PDAC models. This application will translate these promising findings into a clinical trial and further optimize this therapy to be effective against metastatic disease.

PI_NAMEs: GERBER, SCOTT ANDREW (contact);LINEHAN, DAVID C

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Acceleration;adaptive immune response;advanced pancreatic cancer;arm;bench to bedside;Biopsy;Blood specimen;Cancer Etiology;Cancer Model;cancer surgery;cancer type;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Clinic;clinical application;Clinical Trials;clinically relevant;Collaborations;Combination immunotherapy;Combined Modality Therapy;cytokine;Cytotoxic T-Lymphocytes;Data;Diagnosis;Disease;Distal;effective therapy;effector T cell;efficacy evaluation;Encapsulated;Excision;Exhibits;first-in-human;Future;Genetically Engineered Mouse;Human;Immune;Immune response;Immune system;Immunologics;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Injections;Innate Immune System;innovation;innovative technologies;Innovative Therapy;Interferon Type II;Interleukin-12;irradiation;Lead;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Liver;Metastatic/Recurrent;microsphere delivery;microsphere encapsulation;Microspheres;multiple sclerosis treatment;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasm Metastasis;novel;Operative Surgical Procedures;Outcome;Pancreas;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;participant enrollment;patient prognosis;Patients;Peptide Hydrolases;peripheral blood;Pharmacologic Substance;Polymers;pre-clinical;Pre-Clinical Model;Primary Neoplasm;Production;Prognosis;Progression-Free Survivals;protein degradation;Publishing;Radiation Dose Unit;Radiation therapy;Research Personnel;Resectable;response;Safety;Sampling;Schedule;success;systemic toxicity;Technology;Testing;Therapeutic;Therapeutic Effect;tool;Translating;treatment optimization;treatment strategy;tumor;tumor microenvironment;tumor-immune system interactions;ultrasound;United States;Unresectable;Work

PROJECT_TITLE: Repolarizing the Tumor and Metastatic Microenvironments to Treat Patients with Pancreatic Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_NAME: PHILADELPHIA VA MEDICAL CENTER

PHR: Previously believed to be uncommon, subscapularis tendon tears are present in 50% of patients undergoing rotator cuff repair. Unrecognized subscapularis tears may be a source of chronic shoulder pain and dysfunction. The objective of this study is to determine the effects of subscapularis tendon tears on shoulder joint damage, function, and pain. The study will identify the mechanisms of these changes and delineate the contribution of the tear alone versus the potential compounding effect of a tear in the setting of shoulder overuse. Results will highlight the importance of detection and influence future clinical studies to reduce pain, improve function, and preserve shoulder joint health. With the high prevalence of subscapularis tears now recognized, this study will have significant impact on the aging and veteran populations, and is highly relevant to the Veterans Health Administration’s mission.

PI_NAMEs: KUNTZ, ANDREW FREDERIC (contact)

PROJECT_TERMS: Affect;Aging;Animal Model;Anterior;Area;Arthroscopy;articular cartilage;Articular Range of Motion;Biological Models;Cartilage;cartilage degradation;Chronic;chronic pain;chronic shoulder pain;Clinical;clinical care;clinical practice;Clinical Research;Clinical Treatment;Clinical Trials;clinically relevant;Complex;Data;design;Detection;Diagnosis;Elasticity;Equilibrium;Evaluation;experimental study;Functional disorder;functional improvement;Future;Gait;Gait abnormality;Hand Strength;Health;High Prevalence;Image;improved;in vivo;Individual;Inflammation;infraspinatous muscle;Injury;insight;joint injury;Joint structure of shoulder region;Joints;kinematics;Knowledge;Limb structure;loss of function;Measurement;Measures;mechanical load;mechanical properties;Mechanics;military veteran;Mission;Modeling;Modulus;Motion;Muscle;Neuropeptides;Operative Surgical Procedures;Pain;pain reduction;Pathology;Patients;Population;pre-clinical;Pre-Clinical Model;preclinical study;preservation;prospective;Protocols documentation;Randomized, Controlled Trials;Rattus;repaired;Research;restoration;Role;Rotation;Rotator Cuff;rotator cuff tear;Running;Series;sham surgery;Shoulder;Source;Structure;subscapularis muscle;supraspinatus muscle;Techniques;Tendon structure;Time;Tissues;treadmill;Treatment outcome;treatment strategy;United States;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: Impact of Overload and Overuse Following Subscapularis Tears: Mechanisms of Shoulder Joint Damage

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Clinician burnout has reached endemic levels and is an established risk factor for cardiovascular disease, but knowledge gaps in assessing and understanding the longitudinal development of burnout hamper risk-based prevention and targeted interventions. We propose a novel digital phenotyping approach using deep learning based on a video-recorded interview about the experiences of emergency clinicans at work with the aim to identify objective digital biomarkers that predict burnout and cognitive functioning in emergency clinicians. We will determine how candidate digital biomarkers relate to physiological markers of chronic stress, and test the potential of digital biomarkers to self-manage burnout risk and promotes low-threshold burnout prevention.

PI_NAMEs: SCHULTEBRAUCKS, KATHARINA  (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accident and Emergency department;acute care;Affect;anthropogenesis;Behavioral;Biological Markers;biomarker panel;Blood specimen;burnout;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular risk factor;care systems;Chronic stress;Clinical;clinical predictors;clinical risk;clinically relevant;cognitive function;cognitive performance;cohort;Computing Methodologies;COVID-19 pandemic;Data;Data Analyses;deep learning;deep learning algorithm;deep neural network;Detection;Development;Diagnostic;digital;Digital biomarker;digital measure;digital phenotyping;Disasters;Emergency Care;Emergency department crowding;Emergency Department Physician;Emergency Nursing;Emergency Situation;Emotional;Emotions;Environment;executive function;experience;Exposure to;Face;Facial Expression;Feedback;Foundations;gaze;Goals;Hair;Head Movements;Health;Health Personnel;Healthcare;Healthcare Systems;High Prevalence;Hydrocortisone;Impaired cognition;improved;Individual;innovation;Intervention;Interview;Knowledge;longitudinal, prospective study;Machine Learning;Mediating;Medical Errors;Methods;Modality;Monitor;mortality;Movement;multimodal fusion;multimodality;Mydriasis;novel;Occupations;Outcome;pandemic disease;Pathology;Patient Care;Patient Self-Report;Patients;Pattern;Pattern Recognition;Performance;Personal Satisfaction;Persons;Physicians;Physiological;predictive marker;Prevention;Prevention strategy;Prognosis;prognostic;prognostic tool;prognostic value;prognostication;programs;Psyche structure;psychologic;psychological outcomes;Public Health;Reporting;Research;response;Risk;safety net;Sampling;Schedule;screening;Secure;Self Care;Self Management;shift work;Sleep;social;Societies;Speech;Stress;stressor;Structure;Symptoms;Testing;Training;training data;transfer learning;Vertebral column;Video Recording;Visit;Voice;Well in self;Work

PROJECT_TITLE: Early Signs:digital phenotyping to identify digital biomarkers for predicting burnout and cognitive functioning in ED clinicians (Early Signs)

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Pancreatic Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Pancreatic cancer is currently the 3rd leading cause of cancer death in the United States with an estimated 56,770 new pancreatic cancer diagnosed in the United States in 2019. Prior epidemiological studies have been limited in size and lacked representation from individuals of African ancestry. We will discover new pancreatic cancer loci by conducting the first genetic study of pancreatic cancer risk specifically focused on African Americans as well as doubling the size of existing GWAS studies of pancreatic cancer.

PI_NAMEs: KLEIN, ALISON P (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;admixture mapping;African American;African American population;African ancestry;Age;Alcohol consumption;Asian;Body mass index;BRCA1 gene;BRCA2 gene;Cancer Control;cancer diagnosis;Cancer Etiology;cancer genomics;Cancer Patient;cancer risk;case control;CDKN2A gene;Cessation of life;cohort;Data;design;Diabetes Mellitus;Diagnosis;Disease;DNA;epidemiology study;Ethnic Population;Etiology;European ancestry;exome sequencing;Family history of;Frequencies;Funding;gene environment interaction;gene repair;Genes;Genetic;genetic analysis;Genetic study;genetic testing;Genetic Variation;genome sequencing;genome wide association study;genome-wide;genomic locus;Genomic Segment;Genotype;Geographic Locations;Germ Lines;Goals;Hereditary Disease;Heritability;improved;Incidence;Individual;Inherited;Knowledge;Laboratory Research;Lead;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Meta-Analysis;Methods;Mismatch Repair;multi-ethnic;Mutation;National Cancer Institute;Newly Diagnosed;novel;Oncogenes;PALB2 gene;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;Pathogenicity;Patients;Population;Population Genetics;Population Group;Prevention;recruit;Research;Risk;Risk Factors;risk variant;Role;Sample Size;Signal Transduction;Smoking;study population;Susceptibility Gene;Testing;Twin Multiple Birth;United States;Variant;whole genome;Work

PROJECT_TITLE: Multi-Ancestry Mapping of Pancreatic Cancer Susceptibility Loci

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Health Services;Networking and Information Technology R&D (NITRD)

ORG_CITY: FAIRFAX

ORG_NAME: GEORGE MASON UNIVERSITY

PHR: PROJECT NARRATIVE This proposal is to develop a new senior year capstone design course and summer immersion program for Bioengineering students at George Mason University where three neighboring clinical centers will be hosting students for summer immersion. Nursing and Health Informatics and Administration faculty and students will join Bioengineering students and faculty in this senior design program to provide a bread of skills for solving clinical challenges involving medical data and patient-oriented care. Industry advisors will be members of the advising teams to provide guidance on marketability and product development for novel solutions to newly identified clinical needs. 1

PI_NAMEs: ACUÑA, SAMUEL ;ROSS, SHANI  (contact)

PROJECT_TERMS: Academic Medical Centers;Address;Advocate;Biocompatible Materials;Biomedical Engineering;Biomedical Technology;Bread;Businesses;Caring;Child;Clinical;clinical center;Clinical Medicine;cohort;Collaborations;college;Computer-Aided Design;computerized tools;Data;design;Development;diagnostic tool;Discipline of Nursing;Educational Curriculum;Educational process of instructing;Educational workshop;engineering design;Ethics;experience;Faculty;Foundations;Graduate Education;health administration;health data;Health Policy;Health Professional;high school;Immersion;Industry;Industry Standard;Intellectual Property;Knowledge;Learning;Marketing;Medical;Medical center;Medical Device;member;multidisciplinary;novel;Nursing Faculty;Nursing Informatics;Nursing Students;oral communication;Outcome;Participant;Patient Care;patient oriented;Performance;Phase;Physicians;Population;Positioning Attribute;Process;product development;professional students;programs;Public Health Informatics;recruit;Regulatory Pathway;Resources;Risk;skills;Students;summer student;Technology;Training;translational approach;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: Clinical Immersion with Health Professionals and Industry Advising in Undergraduate Biomedical Engineering Capstone Design


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: Project Narrative About half of extremely premature infants develop lung disease (bronchopulmonary dysplasia), which is associated with high rates of poor outcomes. A large ongoing trial in the NICHD Neonatal Research Network will evaluate whether hydrocortisone treatment reduces bronchopulmonary dysplasia and improves outcomes at 2 years in high-risk preterm infants. The proposed study will measure how hydrocortisone and lung disease affect the functional respiratory and developmental outcomes of this established trial population at 5 years old, or early school age.

PI_NAMEs: DAS, ABHIK  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 5 year old;Affect;Age;Biometry;Bronchopulmonary Dysplasia;Caring;Child;Clinical;clinical center;clinical practice;Clinical Research;Clinical Trials;Cognitive;cohort;Cohort Studies;Collaborations;Companions;Consensus;Counseling;Data;data cleaning;Data Coordinating Center;data management;data quality;Data Reporting;Data Set;Development;economic outcome;Education;electronic data;Enrollment;Ensure;Evaluation;Event;evidence base;exercise capacity;experience;Exposure to;extreme prematurity;Failure;flexibility;follow-up;Follow-Up Studies;Functional impairment;Future;Goals;health economics;high risk;Human Resources;Hydrocortisone;Impairment;improved;improved outcome;infancy;Infant;Information Dissemination;Informed Consent;Infrastructure;Institution;Intervention Studies;Journals;Knowledge;Leadership;Letters;Longterm Follow-up;Low Birth Weight Infant;Lung Diseases;Manuals;Measures;meetings;Monitor;motor impairment;Multicenter Neonatal Research Network;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;neonatal lung disease;neonatal respiration;neonate;Network Infrastructure;Newborn Infant;novel;Oscillometry;Outcome;Outcome Study;Parents;Participant;Patients;payment;Peer Review;Phase;placebo controlled trial;Population;Premature Infant;prevent;primary outcome;Process;Productivity;programs;Protocols documentation;Publications;Qualifying;Recording of previous events;Records;Reporting;Research;Research Personnel;Resources;respiratory;Respiratory Failure;Running;Safety;Sample Size;Sampling Studies;School-Age Population;Schools;Services;Severities;Statistical Data Interpretation;Structure;System;Testing;tool;Training;United States National Institutes of Health;Update;Visit;Walking;Work

PROJECT_TITLE: Neonatal Research Network Data Coordinating Center (DCC) 2023-2028


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: PROJECT NARRATIVE Small cell lung cancer (SCLC) patients frequently suffer from relapse and resistant disease with a large number of these resistance mechanisms remaining elusive. From a genetic screen followed by functional validation and clinical genomic correlation, we identified a putative resistance biomarker in SCLC for both current and novel drug therapies (i.e. cisplatin and PARP inhibitors, respectively). This proposal aims to understand how this biomarker works in a protein-recycling pathway (i.e. ubiquitin-proteasome pathway) and DNA repair with identification of novel treatments for treatment resistant/relapsed SCLC dependent on this biomarker to improve outcomes for afflicted patients.

PI_NAMEs: LOK, BENJAMIN H (contact);RAUGHT, BRIAN

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Amino Acid Sequence;Antibodies;Behavior;Biochemical;Biological;Biological Assay;Biological Markers;Biology;Biotin;brca gene;BRCA mutations;Cancer cell line;Cancer Etiology;Cancer Patient;Cell Line;cell type;Cellular Assay;Cessation of life;chemotherapy;chromosome 2p loss;Cisplatin;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Code;Complementary DNA;Complex;CRISPR library;CRISPR screen;CRISPR/Cas technology;CUL1 gene;Custom;Disease;Disease Resistance;DNA Damage;DNA Repair;DNA Repair Pathway;Enzymes;Etoposide;Exhibits;F Box Domain;F-Box Proteins;FDA approved;functional genomics;Gene Targeting;Genes;Genetic Screening;genome-wide;Genomics;Goals;homologous recombination;homologous recombination deficiency;improved;improved outcome;In Vitro;in vivo;inhibitor;insight;Knock-out;Laboratories;Libraries;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Mediator;men;Modeling;Molecular;multicatalytic endopeptidase complex;Mutagenesis;Mutate;Mutation;novel;novel therapeutics;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;pre-clinical;Protein Cycling Pathway;Proteins;Radiation therapy;recombinational repair;recruit;Recurrent disease;Recycling;Regulation;Relapse;relapse patients;Reporter;Reporting;Resistance;resistance mechanism;response;restoration;Role;small cell lung carcinoma;small hairpin RNA;Structure;synthetic lethal interaction;Tertiary Protein Structure;Therapeutic;therapeutic development;therapy resistant;treatment response;tumor;Ubiquitin;ubiquitin-protein ligase;Up-Regulation;Validation;vector;Woman;Work;Xenograft procedure

PROJECT_TITLE: Understanding the molecular mechanism of a protein-recycling complex in small cell lung cancer treatment resistance.


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Malaria is an infectious disease that continues to cause extensive morbidity and mortality throughout tropical and sub-tropical regions of the developing world, especially among young children in sub-Saharan Africa. This project focuses on the ability of malaria parasites to avoid the human immune response and to cause severe disease. A better understanding of these processes will lead to new forms of treatment that will help to relieve the enormous public health burden that malaria inflicts on the developing world.

PI_NAMEs: DEITSCH, KIRK W (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adhesions;Adhesives;Africa;Africa South of the Sahara;African;Anemia;Antibodies;Antibody Response;Antigenic Variation;Babesia;Binding;Biological Process;Blood Vessels;Cell surface;Cells;Cerebral Malaria;Characteristics;Child;chromatin modification;chronic infection;Communicable Diseases;Communication;Data;design;Disease;Endothelium;Epigenetic Process;Epitopes;Erythrocytes;Event;exhaust;Exposure to;Family;Freezing;Gene Activation;Gene Deletion;Gene Expression;Gene Family;Gene Modified;gene network;Gene Order;Gene Silencing;Gene Structure;Genes;Genetic Transcription;Genome;Haploidy;Heart;Human;Immune response;Immune system;Individual;Infection;Infectious Agent;Length;Malaria;malaria infection;mathematical model;Mediating;member;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;Nature;Nonsense-Mediated Decay;Open Reading Frames;parasite genome;parasite invasion;Parasitemia;Parasites;Pattern;Persons;Phenotype;Placenta;Plasmodium;Plasmodium falciparum;Play;Population;Positioning Attribute;Pregnancy;Pregnant Women;Probability;Process;Property;Proteins;Public Health;receptor;Reporter;Role;Severities;Structure;Surface;Surface Antigens;Switch Genes;Syndrome;System;Testing;Time;Trypanosoma;Virulence;Work

PROJECT_TITLE: A structured transcriptional switching network that coordinates antigenic variation by malaria parasites

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative  The overarching goal of this project is to evaluate the activity of the Tat inhibitor, didehydro-Cortistatin A (dCA), for inhibition of HIV transcription. Tat inhibitors are not yet part of the clinical antiretroviral ammunition despite their immense potential at shutting down particle production from infected cells and blocking Tat toxicity. We expect to gain valuable insight into the potentially transformative benefits of adding HIV transcriptional inhibitors to current antiretroviral therapy, whether dCA could act as a single-therapy to block HIV expression, and whether dCA can limit virus recrudescence when therapy is interrupted.

PI_NAMEs: EVANS, DAVID T;VALENTE, SUSANA T (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Acute;acute infection;age acceleration;Anatomy;Anti-Retroviral Agents;antiretroviral therapy;Biological Assay;Biopsy;Blood;CD4 Positive T Lymphocytes;Cells;Chemistry;Chronic;Clinic;Clinical;Colon;comorbidity;Complete Blood Count;cortistatin;Development;Disease Progression;Disease remission;disease transmission;DNA;Dose;Drug Kinetics;Drug or chemical Tissue Distribution;epigenetic silencing;Evaluation;experience;experimental study;fighting;Genetic Transcription;Goals;HIV;HIV Infections;HIV-1;Hormones;humanized mouse;immune activation;Immune System Diseases;In Vitro;Individual;Infection;Inflammation;inflammatory marker;inhibitor;Injections;insight;Interruption;Label;lymph node biopsy;Macaca;Macaca mulatta;Malignant Neoplasms;Measurement;Measures;Mediating;memory CD4 T lymphocyte;Modeling;Monitor;mouse model;Mucous Membrane;novel strategies;particle;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phase;Plasma;prevent;Production;promoter;Provirus Integration;Recrudescences;Regimen;Residual state;Resistance;Rest;RNA;Safety;Serum;Shock;simian human immunodeficiency virus;SIV;small molecule;subcutaneous;T cell reconstitution;T-Cell Depletion;Time;Tissues;Toxic effect;transcriptome sequencing;Variant;Viral;Viral Proteins;viral rebound;Viral reservoir;viral RNA;Viremia;Virus;Virus Replication

PROJECT_TITLE: Evaluation of didehydro-Cortistatin A as a block-and-lock agent for a functional HIV cure in a macaque model

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: The Covid pandemic and the continued rise of fentanyl and stimulant use have dramatically worsened the national public health crisis of substance use in the US. Our work will provide clinicians, policymakers, and community organizations with critically needed guidance about strategies to mitigate the consequences of opioid and stimulant use and improve quality of life and health equity for people with substance use disorder.

PI_NAMEs: OWENS, DOUGLAS K (contact)

PROGRAM_OFFICER_NAME: HARTSOCK, PETER

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Alaska Native population;American Indian Population;Area;Award;Black race;Cessation of life;Communities;community organizations;COVID-19;COVID-19 pandemic;Dimensions;Disease;Disease Outbreaks;Drug abuse;Epidemic;epidemiological model;Epidemiology;Equity;Ethnic Origin;Fentanyl;fentanyl use;fighting;Funding;Grant;Guidelines;Harm Reduction;health disparity;health equity;Health Promotion;Hepatitis C Transmission;Hepatitis C virus;high risk;HIV;HIV/HCV;Housing;implementation barriers;improved;Incidence;Individual;Inequity;International;Intervention;intervention delivery;Latinx;Length;Life Expectancy;marginalized community;Measures;medication-assisted treatment;methamphetamine use;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;naloxone dispensing;National Institute of Drug Abuse;Opioid;opioid epidemic;opioid use;Outcome;Overdose;overdose death;Paper;Peer Review;Persons;Policies;Policy Maker;Population;population health;Prevalence;prevent;Prevention;Prevention strategy;programs;psychosocial;Public Health;Publishing;Quality of life;Race;Resources;SARS-CoV-2 transmission;screening;social;social health determinants;sociodemographics;stem;Stimulant;stimulant use;structural determinants;substance use;Substance Use Disorder;syndemic;transmission process;Virus Diseases;Work

PROJECT_TITLE: Making Better Decisions: Policy Modeling for AIDS and Drug Abuse

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Genetics;Neurosciences;Patient Safety;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: NEUROSURGERY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder leading to deficient synthesis of dopamine and serotonin in the brain. Delivery of a functional copy of the DDC gene would significantly reduce suffering in afflicted patients and pave the way for registration of other gene therapies for neurological disease.

PI_NAMEs: BANKIEWICZ, KRYSTOF S (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 4 year old;affective disturbance;Age;aged;amino acid therapy;Amino Acids;Anesthesia procedures;aromatic L-amino acid decarboxylase deficiency;Aromatic-L-Amino-Acid Decarboxylases;Bilateral;Biological Markers;Biological Products;Brain;brain metabolism;California;Cannulas;Carboxy-Lyases;Childhood;Chronic;Clinical;clinical efficacy;Clinical Trials;cohort;Control Groups;Convection;Corpus striatum structure;Data;debilitating symptom;Developmental Delay Disorders;Diagnosis;Disease;Disorder of neurometabolic regulation;Dopamine;dopaminergic neuron;Dose;Dyskinetic syndrome;Dystonia;efficacy study;Enrollment;Enzymes;Epinephrine;Ethics Committees;Exhibits;Family;Funding;Future;gene replacement;gene therapy;Gene Transfer;Genes;Genetic;Goals;Head;Human;improved;Individual;Infusion procedures;Intellectual functioning disability;Involuntary Movements;Lead;Licensing;Magnetic Resonance Imaging;Measures;Medical;Midbrain structure;Moods;Motor;Motor disability;Movement;Multicenter Studies;Muscle;Muscle hypotonia;Mutation;Natural History;Nervous System Disorder;Neurologic Dysfunctions;Neurotransmitters;Norepinephrine;novel;Ohio;open label;Operative Surgical Procedures;Outcome;pars compacta;patient advocacy group;Patients;Pharmaceutical Preparations;Phase;Phase I/II Trial;Physiological;Poland;Positron-Emission Tomography;Procedures;programs;prospective;Quality of life;rare genetic disorder;Recombinant adeno-associated virus (rAAV);Recommendation;recruit;Research;Research Design;restoration;Safety;safety and feasibility;safety assessment;safety study;San Francisco;Serotonin;Side;Signal Transduction;Sleep;Sleep disturbances;Standardization;Structure;Substantia nigra structure;Symptoms;Time;Trust;United States National Institutes of Health;Universities;uptake;vector;Ventral Tegmental Area;Waiting Lists;Walking

PROJECT_TITLE: A Safety and Efficacy Study of AAV2-hAADC for AADC Deficiency


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: One in three women and one in six men over age 50 will suffer a spine fracture in their remaining lifetime. This project focuses on determining how age-related changes in the structure of a key region of the bone in the spine, and degeneration of the intervertebral discs adjacent to this bone, affect the likelihood of fracture.

PI_NAMEs: MORGAN, ELISE F (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Adult;Affect;Age;age related changes;Aging;aging population;Biochemical;Biological Assay;Biomechanics;bone;Bone Density;Bone Tissue;Cadaver;Cartilage;Characteristics;Classification;Clinical;Collagen;Coupled;crosslink;Data;density;Dependence;Diagnostic;diagnostic tool;Elderly;Elements;experimental study;Failure;Fracture;fracture risk;Future;Goals;Health;high risk;Human;Image;image guided;improved;Incidence;innovation;interdisciplinary approach;Intervertebral disc structure;intervertebral disk degeneration;Magnetic Resonance Imaging;Measurement;Measures;mechanical behavior;mechanical properties;Mechanics;Mediating;men;Methods;microCT;Minerals;model building;Modeling;Modulus;novel;Osteoporosis;Outcome;Pathogenesis;Patient Compliance;Patients;Performance;Persons;pre-clinical;predictive tools;Prevention;Process;Property;Publishing;Resolution;Rest;Risk;Risk Factors;Scanning;simulation;Specimen;Spinal Fractures;spine bone structure;Stress;Structure;substantia spongiosa;Surface;Testing;Thick;three-dimensional visualization;Tissues;Treatment Protocols;Vertebral column;Woman;X-Ray Computed Tomography

PROJECT_TITLE: 3-D Visualization and Prediction of Vertebral Fractures

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE Re: Sani Kizilbash, MBBS, MPH (eRA Commons ID: skizilbash, FOA # RFA-FD-21-001) WSD0922-FU is a novel drug which both penetrates into brain cancers and blocks a genetic change in the cancer (EGFR) that is critical for brain cancer growth and survival. The clinical trial proposed in this research study will determine the safety of WSD0922-FU in patients with brain cancers and will provide valuable data on how effective this drug can be in these patients. The results of this research will accelerate progress in developing new treatment strategies for patients with these brain cancers, and may eventually improve patient survival.

PI_NAMEs: KIZILBASH, SANI HAIDER (contact)

PROGRAM_OFFICER_NAME: NUGENT, BRIDGET

PROJECT_TITLE: Phase I study to evaluate safety, tolerability, pharmacokinetics and anti-tumor activity of WSD0922-FU


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE Epilepsy is now believed to result from aberrant activity of multiple neural “nodes” that together create a self- reinforcing network phenomenon. Standard clinical electrodes used in the diagnosis and treatment of drug- resistant epilepsy do not offer sufficiently fine resolution for microscale interrogation of the epileptogenic networks. This project aims to deliver a fully wireless multi-thousand channel electrode system with large-scale but precise cortical coverage, which will advance our understanding and treatment of epilepsy through analysis of neural activity at an unprecedented resolution, as demonstrated in acute human studies, semichronic animal safety and efficacy tests, and a small clinical trial.

PI_NAMEs: DAYEH, SHADI  (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Acute;Anatomy;Animal Model;animal safety;Animal Testing;Animals;Area;Authorization documentation;Biological Markers;biomaterial compatibility;Biophysics;Brain;Brain imaging;brain machine interface;Brain region;brain tissue;Certification;Charge;Chronic;Clinical;clinical biomarkers;Clinical Trials;Computer software;Craniotomy;cranium;Data;Data Analyses;data exchange;density;Development;Device or Instrument Development;Devices;Diagnosis;Diagnostic;Diameter;efficacy testing;electric impedance;Electrocorticogram;Electrodes;Electronics;Electrophysiology (science);Epilepsy;epileptiform;ergonomics;Excision;fabrication;Family suidae;Feasibility Studies;Film;Generations;Goals;Grant;High Frequency Oscillation;Histologic;Human;Impairment;Implant;Incidence;Injections;Institutional Review Boards;integrated circuit;Intractable Epilepsy;Laboratories;Language;manufacturing process;Maps;Measures;Medical Device;meetings;Methods;Microelectrodes;Microfabrication;miniaturize;minimally invasive;Monitor;Motor;Movement;nanorod;neural;neuroregulation;Neurostimulation procedures of spinal cord tissue;novel;Operative Surgical Procedures;Outcome;parylene C;Pathologic;Patients;Performance;Phase;phase 2 testing;Platinum;pre-clinical;Preclinical Testing;preservation;Procedures;Protocols documentation;Radio;Reaction;Research;Resolution;Safety;safety testing;Seizures;Signal Transduction;software development;Source;Structure;success;Surface;System;Systems Development;Systems Integration;Technology;Testing;Therapeutic;Therapeutic procedure;Thinness;Tissues;transmission process;Vision;Visualization;wireless;wireless sensor

PROJECT_TITLE: Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


ORG_CITY: SAN ANTONIO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Project Narrative Scleroderma is a chronic disease of the connective tissue that is characterized by excessive accumulation of fibrous material (i.e. collagen) in the skin and ultimately in the lungs and other internal organs leading to multiple organ failure and death. Although there is no cure for this disease, research progress in animals and humans has led to better understanding of the disease process, and possible treatment options that can halt or reverse the disease are on the horizon. Recently, our research identified that an FDA-approved drug (for other disease) might be effective for scleroderma, and we now propose to conduct additional studies to develop the drug, as well as understand the mechanism(s) by which it blocks collagen accumulation in cells obtained from scleroderma patients, and in animal models of the disease.

PI_NAMEs: GHEBRE, YOHANNES T (contact)

PROGRAM_OFFICER_NAME: PARK, HEIYOUNG

PROJECT_TERMS: 3-Dimensional;Affect;analog;Animal Disease Models;Animal Model;Animals;Anti-Inflammatory Agents;antifibrotic treatment;Appearance;Binding;Binding Sites;Biological;Blood Vessels;Cell Nucleus;Cells;Cessation of life;Chronic;Chronic Disease;Coin;Collagen;Connective Tissue Diseases;Cream;Cutaneous Involvement;Data;Deposition;Dermal;Development;Diffuse;Disease;Distant;efficacy evaluation;Environmental Risk Factor;Esomeprazole;Etiology;Extracellular Matrix Proteins;Family;FDA approved;Fibroblasts;fibrogenesis;Fibrosis;Genetic;heme oxygenase-1;high throughput screening;Human;Image;Immune;Immune System Diseases;Immunosuppressive Agents;In Vitro;in vivo;Inflammation;Inflammatory;insight;Knock-out;knockout animal;Knockout Mice;Lung;MAPK1 gene;Mediating;member;Mitogen-Activated Protein Kinases;Modeling;Molecular;mouse model;Multiple Organ Failure;Mus;Myofibroblast;novel;nuclear factor-erythroid 2;Nuclear Translocation;Oral Administration;Organ;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phosphorylation;Process;Proliferating;Promoter Regions;Pulmonary Fibrosis;Pulmonary Inflammation;reduce symptoms;Regulation;Research;Scleroderma;Secondary to;Skin;skin fibrosis;small molecule;standard of care;Systemic Scleroderma;targeted treatment;Testing;Tissues;Topical application;transcription factor;transdifferentiation;Transforming Growth Factor beta;Universities;Visceral

PROJECT_TITLE: Repurposing esomeprazole for the treatment of scleroderma

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: Project Narrative WHO estimates that there are currently 5 million humans living with some form of lupus. There is a great need for developing effective therapies for lupus, a condition that is difficult to diagnose and treat due to variability of symptoms from person to person. The goal of this grant is to engineer highly potent lymphatic system-targeting nanoparticles for customized delivery of cyclosporine, an immunosuppressive drug often used as last option due inherent shortcomings of conventional formulations, such as poor lymphoid targeting and toxicity.

PI_NAMEs: ARORA, MEENAKSHI ;MAJETI, RAVIKUMAR N (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Affect;Autoimmune Diseases;B-Lymphocytes;Benchmarking;Benefits and Risks;Biological;Biological Availability;Blood flow;capsule;Carbon;CD3 Antigens;cell mediated immune response;Cells;chemokine;chemokine receptor;Chronic;Clinic;Clinical Research;Complement;CXCR4 gene;Cyclosporine;cytokine;Cytostatics;Data;density;design;Diagnosis;Disease;Dose;Drug Delivery Systems;ds-DNA;effective therapy;Engineering;Evaluation;FDA approved;Formulation;Glomerulonephritis;Goals;Grant;Gut associated lymphoid tissue;Human;Human Characteristics;human disease;Immune;Immune system;Immunoglobulin G;Immunologics;immunoregulation;Immunosuppressive Agents;improved;in vivo;Individual;Inflammatory;innovation;Intestines;Kidney;Knowledge;Laboratory Finding;Length;Ligands;Lupus;Lupus Nephritis;Lymph;lymph nodes;Lymphatic;Lymphatic System;Lymphocyte;Lymphoid;Lymphoid Cell;Lymphoid Tissue;Modeling;mouse model;MS4A1 gene;Mus;nanomedicine;nanoparticle;nanosystems;nephrotoxicity;next generation;Nucleosome Core Particle;Oral;Oral Administration;Organ;particle;Patients;Periodicals;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Plasma;Polyesters;Portal vein structure;prevent;prophylactic;rational design;receptor;Regimen;Serum;Severities;side effect;Signs and Symptoms;Site;Spleen;Steroids;Stromal Cell-Derived Factor 1;Structure-Activity Relationship;success;Survival Rate;Symptoms;Systemic Lupus Erythematosus;Technology;Testing;TFRC gene;Therapeutic;therapeutic target;therapy outcome;Tissues;Titrations;Toxic effect;Translating;uptake;Work

PROJECT_TITLE: Engineering the next generation nanoparticle-cyclosporine A therapy in lupus

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: We will perform a detailed cartography of the metabolic programing of the immune cells in the gastrointestinal tract and adjacent tissues and probe the role of metabolism in driving HV pathogenesis by administration of a western diet (WD, rich in fats and sugars, low in fiber) and therapeutic interventions with statins and assessment of their impact on the reservoir seeding, maintenance and reactivation. We developed and optimized the assays necessary for the proposed studies and established strategic collaborations with academic and industry leaders in this field. Importantly, if our strategy is successful, our project could have a major impact in the management of HIV patients, either alone or in combination with latency reversing agents, and will represent a significant step towards a better control of HIV.

PI_NAMEs: APETREI, CRISTIAN  (contact);SAEZ-CIRION, ASIER

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Adipose tissue;antiretroviral therapy;Area;Automobile Driving;Berlin;Biological Assay;Blood;Cancer Cell Growth;CD4 Positive T Lymphocytes;Cell Survival;Cells;Cellular Metabolic Process;Chronic;Collaborations;Consensus;Data;Diet;dietary;Dietary Fats;Dietary Intervention;Dietary Sugars;Disease Progression;Elements;Environment;Epidemic;exhaust;Fasting;Fatty acid glycerol esters;Fiber;gastrointestinal;Gastrointestinal tract structure;Goals;gut health;gut microbiome;Hematopoietic Stem Cell Transplantation;High Fat Diet;HIV;HIV Infections;HIV-1;host microbiome;Human;Immune;immune activation;Immune response;Immune system;Immunity;immunoregulation;improved;Industry;Infection;Inflammation;Inflammatory Bowel Diseases;inhibitor;innovation;Intervention;Knowledge;Link;Lipids;London;Lymphoid Tissue;Macaca mulatta;Maintenance;Malignant Neoplasms;Metabolic;Metabolic Control;Metabolic dysfunction;Metabolic Pathway;metabolic profile;Metabolism;microbiome;microbiome alteration;Mississippi;nonhuman primate;Nutritional;Pathogenesis;Pathologic;Patients;Persons;Plasma;Predisposition;Process;Production;prognostic;Proliferating;Relapse;Reporting;Research;Residual state;response;Role;Scientific Advances and Accomplishments;Shapes;Site;SIV;sugar;T-Cell Depletion;T-Lymphocyte;Therapeutic;Therapeutic Intervention;Tissues;tool;Viral reservoir;Viremia;Virus;western diet;Work

PROJECT_TITLE: Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-S(07)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: NATIONAL DISEASE RESEARCH INTERCHANGE

PHR: Program Director/Principal Investigator (Bell, Thomas, J.): Project Narrative: The first public resource correlating gene expression and genetic variation in pediatric tissues from all major organ systems in the human body will be available to scientists upon the completion of the developmental Genotype-Tissue Expression (dGTEx). To enable this groundbreaking effort, the pediatric Biospecimen Procurement Center (BPC) will provide high-quality tissue samples from a cohort of pediatric donors for the dGTEx project to the pediatric Laboratory Analysis Data Collection Center (LDACC) suitable for their experimental analysis. This proposal supports the development and implementation of the BPC to empower the advancement of pediatric research and the development of new clinical approaches to treat pediatric disorders. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page Continuation Format Page

PI_NAMEs: BELL, THOMAS J (contact);BLANCHARD, THOMAS G;HERNANDEZ, RAQUEL GOMEZ;LINN, REBECCA L;TAYLOR, DEANNE MARIE;VONDRAN, MELISSA

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acceleration;Address;Adult;Anatomy;Authorization documentation;Autopsy;biobank;Bioinformatics;Body System;Brain;Brain imaging;Brain Pathology;brain research;Cells;Cellular biology;Child;Childhood;Clinical;Clinical Investigator;Collection;Communities;community advisory board;Data;Data Analyses;Data Collection;data exchange;Data Storage and Retrieval;design;Development;Developmental Gene;Diagnosis;Disease;early childhood;empowerment;equity, diversity, and inclusion;ethical, legal, and social implication;Ethnic Origin;Evaluation;Exclusion;experimental analysis;Family;Gene Expression;Genetic Variation;Genotype;Genotype-Tissue Expression Project;Grant;health disparity;Health equity research;hospital care;Hospitals;Human body;Image;improved;Informatics;Infrastructure;insight;Institution;Investigation;Laboratories;Lead;Maryland;medical specialties;Methodology;Methods;Modeling;Molecular;Molecular Profiling;novel;operation;Organ Procurements;Pathologic;Pathologist;Pathology;pathology imaging;Pediatric cohort;Pediatric Hospitals;Pediatric Research;Philadelphia;Physiology;Population;postnatal;prepuberty;Principal Investigator;Procedures;Process;programs;Puberty;quality assurance;Quality Control;Race;Recovery;Reliability of Results;Reproducibility of Results;Research;research and development;Research Design;Research Personnel;Resources;Risk;Sampling;Scientist;single cell analysis;Site;social culture;Specimen;Structure;success;Technical Expertise;Techniques;Tissue Banks;Tissue Donations;Tissue imaging;Tissue Sample;Tissues;Training;United States National Institutes of Health;Universities;whole slide imaging

PROJECT_TITLE: Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project