NIH_SPENDING_CATS: Aging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: PROJECT NARRATIVE Glioblastoma (GBM) is an incurable primary brain cancer with a median age at diagnosis of 65 years old and the mechanisms through which advanced age suppress cell intrinsic and extrinsic factors allowing for maintenance and outgrowth of GBM cancer stem cells (CSCs) is unexplored. We recently discovered that the redox gasotransmitter, hydrogen sulfide (H2S), which decreases during advanced age and is suppressed by thyroid hormone activity, enhances immune surveillance and functions as a tumor suppressor in subjects with GBM. By integrating our team’s collective expertise in GBM, CSCs, and H2S, we will interrogate how advanced age changes the brain microenvironment to favor CSC survival and outgrowth through deficiencies in H2S signaling while also leveraging anti-thyroid hormone approaches to reverse H2S declines and improve GBM outcomes in pre-clinical models.

PI_NAMEs: HINE, CHRISTOPHER MICHAEL (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Acceleration;Adult;Affect;Age;age effect;age related decline;aged;Aging;amino acid metabolism;Attenuated;Biological Availability;Brain;cancer stem cell;Cell Maintenance;Cell Proliferation;Cells;Chemicals;Clinical;Clinical Trials;clinically relevant;Cues;Cysteine Desulfhydrase;Data;detection assay;Diagnosis;dietary;Elderly;Enzymes;Epigenetic Process;experimental study;FDA approved;Generations;Genetic;Genetically Engineered Mouse;Glioblastoma;Goals;Growth;hormonal signals;Human;human old age (65+);Hydrogen Sulfide;Hypothyroidism;immune activation;immune function;Immunologic Surveillance;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Intervention;juvenile animal;Knock-out;Knockout Mice;Life;Longevity;Maintenance;Malignant - descriptor;Malignant neoplasm of brain;Mediating;Metabolic;metabolic fitness;Metabolism;Methimazole;Mitochondria;Modeling;Molecular;mouse model;multimodality;neoplastic cell;Nerve Degeneration;neural;novel;Outcome;overexpression;Oxidation-Reduction;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;pre-clinical;Pre-Clinical Model;prevent;Primary Brain Neoplasms;pro-aging;Production;programs;Progression-Free Survivals;Proliferating;Propylthiouracil;Protein S;Proteins;Publishing;Radio;Recurrence;Regulation;Repression;Resistance;response;Role;Sampling;self-renewal;Signal Transduction;Site;Specimen;standard of care;stem cell population;stem cell self renewal;stem cell survival;sulfhydration;Sulfur Amino Acids;synergism;Tamoxifen;temozolomide;Testing;Therapeutic;Therapeutic Effect;Therapeutic Studies;therapy resistant;Thyroid Gland;Thyroid Hormones;Time;Tissues;treatment strategy;tumor;Tumor Burden;tumor growth;tumor initiation;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;tumorigenic;Visit

PROJECT_TITLE: Hydrogen sulfide functions as a tumor suppressor in glioblastoma

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: The Neonatal Research Network (NRN) is an excellent platform for conceiving and completing large, well- designed clinical trials. The NRN has a strong track record of impactful research and ongoing randomized clinical trials in a number of areas of neonatal medicine. The URUB Clinical Center has the leadership, enrollment and follow-up capabilities to continue to be an excellent venue for future, similar successes and has unique, specialized resources and expertise to facilitate cutting-edge research.

PI_NAMEs: BLISS, JOSEPH MARK (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Address;Admission activity;Area;Basic Science;Birth;Black race;Caregivers;Caring;Catchment Area;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Conduct Clinical Trials;COVID-19;Creativeness;Data;data access;Data Collection;data management;data sharing;Databases;Deposition;Discipline of obstetrics;Enrollment;Ethics;Evaluation;experience;Eye;Faculty;Female;follow-up;Future;Geography;Goals;high risk;Hospitals;improved;Infant;Information Systems;Infrastructure;Institution;Investigation;Laboratories;Lactation;Latino;Lead;Leadership;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Measures;Medicine;meetings;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;National Institute of Child Health and Human Development;Neonatal;neonate;network models;novel;organizational structure;Participant;Peer Review;Performance;performance site;perinatal complications;Population;Population Heterogeneity;Pregnancy;programs;Protocols documentation;Race;randomized, clinical trials;recruit;repository;Reproducibility;Research;Research Personnel;Resources;Scientist;Services;Site;social;Specimen;Structure;success;therapy design;Training Programs;United States National Institutes of Health;Universities

PROJECT_TITLE: Rochester-Buffalo Neonatal Research Group


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE High stress during pregnancy has tremendously negative consequences for women’s ability to sensitively care for their infants, as well as derails maternal mental health. Very little is known about how stress is processed by the maternal brain to cause these negative effects, but it may do so through the stress-signaling molecule, corticotropin releasing factor (CRF), interacting with the brain’s serotonin system. Greater knowledge about CRF-serotonin interactions in the maternal brain will greatly improve our ability to understand the mechanisms underlying peripartum stress, thus helping the millions of mothers struggling to care for their infants and suffering from poor mental health.

PI_NAMEs: LONSTEIN, JOSEPH S (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: abuse neglect;Affect;Affective;Anxiety;anxiety symptoms;anxiety-like behavior;Autoradiography;Basic Science;Behavior;behavioral impairment;Birth;Brain;caregiving;Caring;Cells;Chemicals;Corticotropin-Releasing Hormone;Corticotropin-Releasing Hormone Receptors;CRF receptor type 1;Data;depressive symptoms;Development;Dorsal;dorsal raphe nucleus;Down-Regulation;Electrophysiology (science);Ensure;Female;Future;gamma-Aminobutyric Acid;Genes;Goals;high risk;Hormonal;Immunohistochemistry;Impairment;improved;In Situ Hybridization;Infant;innovation;Intervention;Knowledge;Label;Laboratories;Laboratory Rat;Lactation;Life Stress;Ligands;male;maternal anxiety;maternal caregiving;maternal depression;maternal stress;Measures;Mediating;Mental disorders;Mental Health;Messenger RNA;MicroRNAs;Midbrain structure;Modeling;motherhood;Mothers;negative affect;neural;Neurobiology;neurochemistry;neuromechanism;Neurons;Neuropeptides;Neurotransmitters;Perinatal;Phenotype;post pregnancy;Postpartum Period;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prevent;Process;Prosencephalon;protein expression;Quantitative Reverse Transcriptase PCR;Rattus;receptor;receptor expression;Reproduction;Research;Research Methodology;response;Rodent;Serotonergic System;Serotonin;Sex Differences;Signal Transduction;Signaling Molecule;Site;Slice;Source;Stress;System;Technology;Testing;Time;tool;transmission process;Viral Vector;virtual;Woman;women's treatment

PROJECT_TITLE: Neural Basis of Stress-Derailed Motherhood

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Lewy Body Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  Alzheimer’s Disease and related dementias are heritable, severe, and complex brain disorders character- ized by substantial clinical and biological heterogeneity. Thus far, we haven’t been able to fully leverage the whole spectrum of multi-omics datasets that have been generated from molecular profiling efforts to identify genetically driven gene dysregulation for dementias. This project will use cell-type and area specific imputed transcriptomes, proteomes and epigenomes for Alzheimer’s disease, frontotemporal lobar degeneration and dementia with Lewy bodies which will be integrated with a novel data-driven correlation-aware approach to- wards identifying key associated genes.

PI_NAMEs: VOLOUDAKIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;analytical method;Area;Awareness;Biological;Biological Assay;biological heterogeneity;Biological Process;Brain;brain cell;Brain Diseases;Brain region;brain tissue;causal variant;Cell Nucleus;Cell Separation;cell type;Chromatin;clinical heterogeneity;Code;Complex;Data;data integration;Data Set;Dementia;Dementia with Lewy Bodies;Development;Disease;disorder risk;drug development;Drug Targeting;Epigenetic Process;epigenetic profiling;epigenome;Formulation;Frontotemporal Lobar Degenerations;Future;Gene Expression;Genes;Genetic;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic approach;Genomics;Genotype;Goals;Heritability;histone modification;Human;improved;Intervention;Lewy Body Dementia;Linkage Disequilibrium;Mediating;Meta-Analysis;Modeling;Molecular Profiling;multi-scale modeling;Multiomic Data;neuropsychiatric disorder;next generation;novel;novel strategies;online resource;Outcome;Pathway interactions;Positioning Attribute;Prefrontal Cortex;Proteome;Proteomics;psychopharmacologic;Regulation;Research;Resources;Risk;risk variant;Role;Schizophrenia;Sorting;Specificity;statistics;Therapeutic Intervention;Tissues;Training;trait;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;Untranslated RNA;Variant

PROJECT_TITLE: Identifying genetically driven gene dysregulation in Alzheimer's disease and related dementias using statistical data integration

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Genetics;HIV/AIDS;Human Genome;Infectious Diseases;Patient Safety;Precision Medicine

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Approximately 1.2 million individuals in the United States and 38 million worldwide are living with HIV. A better understanding of how human genetics affect how people living with HIV respond to various treatments that have been studied in clinical trials may be used to ultimately improve the lives of people living with HIV in the US and worldwide.

PI_NAMEs: HAAS, DAVID W (contact);RITCHIE, MARYLYN D

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: absorption;Acceleration;Affect;AIDS clinical trial group;Anti-Retroviral Agents;Anti-viral Agents;antiretroviral therapy;Biology;Cells;Chronic;Clinical;clinical care;clinical effect;Clinical Trials;clinically relevant;cohort;Collaborations;Complex Genetic Trait;Computerized Medical Record;Data;Data Analyses;Data Set;Databases;Drug Interactions;Drug Kinetics;Drug toxicity;endophenotype;Epidemiology;Exogenous Factors;FDA approved;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;genetic association;Genetic Polymorphism;Genetic Transcription;genetic variant;Genome;genome wide association study;genome-wide;Genomic approach;genomic data;Genotype;Goals;Heritability;HIV;HIV therapy;HIV-1;Human Genetics;Human Genome;Immune;immune activation;improved;Individual;Infection;Inflammation;Injectable;inter-individual variation;interest;Intervention;Intervention Trial;Laboratories;Messenger RNA;Metabolism;Methodology;non-genetic;novel;novel therapeutics;Organ;Pathology;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacogenomics;phenome;Phenotype;polygenic risk score;Predisposition;prevent;prospective;Randomized;Recovery;Research;Research Personnel;response;Risk;Single Nucleotide Polymorphism;Specimen;System;Tablets;Technology;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;Toxic effect;trait;Transcript;transcriptome;Translating;treatment response;Treatment-related toxicity;United States;Variant;Virus Replication;Visualization;whole genome;Work

PROJECT_TITLE: Pharmacogenomics of HIV Therapy

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation;Sleep Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of therapeutic interventions such as deep brain stimulation on sleep-related neuronal activity and sleep behavior, are not well understood. Results from this study will provide a better understanding of the brain circuitry involved in disordered sleep in PD and inform the development of targeted therapeutic interventions to treat sleep disorders in people with neurodegenerative disease.

PI_NAMEs: JOHNSON, LUKE AARON (contact)

PROGRAM_OFFICER_NAME: CHO, HYUN JOO

PROJECT_TERMS: actigraphy;Affect;Basal Ganglia;Behavior;Biological Markers;biophysical model;Brain;brain circuitry;Characteristics;Clinical;Clinical Data;Coupling;Data;Deep Brain Stimulation;design;Development;Diffusion;Disabling;Disease;Electrocorticogram;Electrophysiology (science);Excessive Daytime Sleepiness;Frequencies;Goals;imaging facilities;improved;improvement on sleep;Individual;individual patient;Infrastructure;insight;invention;Knowledge;Magnetic Resonance;Magnetic Resonance Imaging;Maintenance;Measures;Minnesota;Modeling;Motor;motor disorder;motor symptom;Nervous System Disorder;Neural Pathways;Neurodegenerative Disorders;Neurons;neurophysiology;neuroregulation;non rapid eye movement;novel;Operative Surgical Procedures;Outcome;Parkinson Disease;Pathologic;Pathway interactions;Patients;Pattern;Persons;Physiologic pulse;Physiological;Play;pre-clinical;Prefrontal Cortex;Quality of life;REM Sleep;Reporting;Research;Resistance;Resolution;Role;Sleep;sleep behavior;Sleep Disorders;Sleep disturbances;Sleep Fragmentations;sleep quality;sleep regulation;Sleep Wake Cycle;targeted treatment;Therapeutic;Therapeutic Effect;Therapeutic Intervention;tractography;Universities

PROJECT_TITLE: Sleep-specific DBS therapy in Parkinson's disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Antibodies are proteins in the blood that protect against - and indicate past exposure to - pathogens, however the number of possible antibody targets is vast, making it difficult to develop a comprehensive view from a single blood sample. This project aims to develop a technology that enables antibodies against 100,000s of custom targets to be measured simultaneously using a small drop of blood, with an initial focus on antibodies that recognize any of the >300 viruses capable of infecting humans. Success in this project will provide a new and powerful tool for monitoring the immune response that will be broadly applicable for basic and clinical research.

PI_NAMEs: ALTIN, JOHN  (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Allergens;Amino Acids;Antibodies;Antibody Response;antibody test;Antigens;assay development;Autoantigens;Autoimmune Diseases;B-Lymphocytes;Bar Codes;Basic Science;Benchmarking;Biological Assay;Biological Markers;Blood;Blood specimen;Cells;Clinical Research;cohort;Communities;cost;Custom;Data;data access;Data Analyses;Data Set;data visualization;Databases;design;Disease;DNA;DNA sequencing;Drops;Dryness;Epidemiologic Monitoring;Evaluation;Event;Exposure to;Frequencies;Generations;Genome;Gold;Human;human virome;IgE;immune function;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulin M;Immunologic Monitoring;Immunology;In Vitro;Individual;Length;Libraries;Link;longitudinal analysis;Measures;Methods;Monitor;Mutagenesis;open data;pathogen;pathogen exposure;Peptides;Performance;Plasma;Population;Procedures;Process;Production;Proteins;Protocols documentation;Reproducibility;Research;Resolution;Resources;Sampling;Sensitivity and Specificity;Serology test;Seroprevalences;Serum;Signal Transduction;single cell sequencing;Specificity;Spottings;Standardization;success;System;Technology;Testing;Time;Titrations;tool;transcriptome;transcriptome sequencing;transcriptomics;Vaccines;Variant;Viral;Viral Antibodies;virome;Virus;Visualization software

PROJECT_TITLE: A scalable platform for highly-multiplexed analysis of antibody reactivity from <1uL of blood


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Pancreatic cancer claims the lives of 47,000 Americans annually; therefore, understanding the mechanisms that contribute to the initiation and progression of this disease is of great significance. Previous work has demonstrated that MTOR signaling play an important role during pancreatic tumorigenesis and that inhibition of MTOR can prolong survival in model systems. The proposed project will assess the impact of inhibiting MTOR in established pancreatic tumors, thus potentially leading to the development of novel therapeutic strategies and thereby reducing the impact of this disease on public health.

PI_NAMEs: LEWIS, BRIAN C (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Ablation;Acute;American;aurora B kinase;Biological Models;Cancer cell line;Cancer Etiology;Cell Line;Cell Survival;Cessation of life;Combined Modality Therapy;Complex;Credentialing;Critical Pathways;Data;data integration;Data Set;Development;Diagnosis;Disease;Disease Progression;gemcitabine;Gene Expression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Goals;Human;Impairment;in vivo;K-ras mouse model;knock-down;Knock-out;KRAS2 gene;KRASG12D;Laboratories;Lesion;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;MEK inhibition;MEKs;Modeling;Molecular;mouse model;mTOR inhibition;mTOR Inhibitor;mutant;Mutation;novel;novel therapeutic intervention;Organoids;overexpression;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pancreatic Intraepithelial Neoplasia;pancreatic neoplasm;pancreatic tumorigenesis;Pathway interactions;Phenotype;Phosphotransferases;Play;Proteomics;Public Health;Publishing;recombinase;Regimen;Resistance;resistance mechanism;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;statistics;Therapeutic;therapeutic target;Treatment Efficacy;tumor;tumor microenvironment;United States;Work

PROJECT_TITLE: Targeting MTOR signaling in pancreatic cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_STATE: OH

PHR: PROJECT NARRATIVE Alcohol abuse is a leading cause of morbidity and mortality worldwide and recent data indicate that alcoholic liver disease affects over 10 million Americans. The overall goal of the Northern Ohio Alcohol Center (NOAC) is to identify specific molecular targets of ethanol-induced damage, as well as understand the complex adaptive and maladaptive responses of cells and systems to that damage. This information will enable us to target therapeutic interventions that will either slow and/or reverse the progression of disease in patients suffering from injury due to excessive alcohol consumption.

PI_NAMEs: NAGY, LAURA E. (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acute;Address;Adipose tissue;Affect;Alcohol abuse;Alcohol consumption;alcohol exposure;alcohol research;Alcohol-Induced Disorders;Alcoholic beverage heavy drinker;Alcoholic Liver Diseases;Alcohols;American;Animal Model;Animals;Apoptosis;Area;Biological Assay;Biological Markers;Brain;Cell Separation;Cells;Cessation of life;Chronic;chronic alcohol ingestion;circadian pacemaker;circulating biomarkers;Clinic;Clinical;Clinical Investigator;clinical translation;clinically relevant;comorbidity;Complex;Core Facility;Data;design;Development;Disease;Disease Progression;drug testing;effective therapy;efficacy evaluation;efficacy testing;Ethanol;Funding;Future;Genetic;glial activation;Goals;Heavy Drinking;Hospitals;Image;Impairment;Individual;Inflammation;Injury;Institution;International;Intestines;Investigation;Kidney;Lipids;Liver;liver injury;Mediator;Medical;microbial;Microglia;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;National Institute on Alcohol Abuse and Alcoholism;neural;neuroinflammation;novel;novel strategies;novel therapeutic intervention;Nutrient;Nutritional;Ohio;Organ;organ injury;Patients;Pediatric Hospitals;Peer Review;Pharmaceutical Preparations;Pilot Projects;Population;prevent;problem drinker;Public Health;Publications;Publishing;rational design;Research;research and development;Research Personnel;Resource Development;Resources;response;Role;Sampling;sarcopenia;Scientist;senior faculty;Site;Skeletal Muscle;skeletal muscle wasting;Standardization;Stress;Structure;student training;synergism;System;targeted treatment;Testing;Therapeutic Intervention;therapy development;tissue injury;Tissues;Training;Translating;translational scientist;treatment strategy;two photon microscopy;two-photon;Universities;Work

PROJECT_TITLE: Alcohol and tissue injury, from mechanisms to treatments


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;Liver Disease;Substance Misuse

PROJECT_TERMS: Alcoholic Liver Diseases;Alcohols;Animal Model;Award;Basic Science;Biochemistry;Bioinformatics;Budgets;Cell model;Chemistry;Clinical;clinical practice;Clinical Sciences;Communities;Discipline;Education;effective therapy;Ethanol;Functional disorder;Gastroenterology;Genetic;Goals;Grant;Hepatology;interdisciplinary collaboration;interest;large datasets;meetings;Metabolism;Molecular;Monitor;novel;Ohio;Organ;organ injury;Pathology;Pilot Projects;programs;Reporting;Research;Research Personnel;Resource Development;Sampling;Scientist;Speed;symposium;System;tissue injury;Training;Translating;Translations;Travel;treatment strategy;Visit

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: GALVESTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PUBLIC HEALTH RELEVANCE This research is relevant to public health and the mission of NIH, because it will evaluate the therapeutic potential of the transcription factor DFosB for combatting the effects of substance use disorder. To this end, we will delineate and then specifically target molecular features in DFosB in order to define the mechanisms by which they regulate drug addictive behaviors. The genetic models and chemical probes targeting DFosB developed in this proposal will also enable us to validate a dramatically novel strategy to mitigate drug addictive behaviors, which is important for addressing the opioid epidemic.

PI_NAMEs: NESTLER, ERIC J.;ROBISON, ALFRED J;RUDENKO, GABRIELLE  (contact);ZHOU, JIA

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: addiction;Addictive Behavior;Address;Adopted;Affinity;Animal Model;Architecture;Behavior;Behavioral;behavioral outcome;behavioral response;Binding;Biological Assay;Biophysics;Brain;Cell Culture Techniques;Cell model;Cells;Chemicals;Chronic;Cocaine;cocaine exposure;combat;Complex;Corpus striatum structure;Data;Development;Diagnostic;Dimerization;DNA;DNA Binding;Dorsal;Drug Addiction;drug development;drug discovery;Drug Industry;drug of abuse;drug reward;Drug Targeting;Drug usage;Drug Use Disorder;Event;Exposure to;Family;Functional disorder;Funding;G-Protein-Coupled Receptors;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Models;Genetic Transcription;Goals;Heroin;Human;In Vitro;in vivo;in vivo evaluation;Industry;innovation;insight;Knowledge;Lead;Macromolecular Complexes;Mediating;Mental disorders;Mission;Molecular;Molecular Mechanisms of Action;Molecular Target;mouse model;Mus;Mutagenesis;Mutation;neural;new therapeutic target;novel;novel strategies;Opioid;opioid epidemic;opioid exposure;opioid use disorder;Outcome;Oxidation-Reduction;Pharmaceutical Preparations;pharmacologic;Play;pre-clinical;programs;Proteins;Public Health;public health relevance;Regulation;Relapse;Research;response;Rewards;Risk;Rodent Model;Role;scaffold;Self Administration;Series;small molecule;stimulant use;Substance Use Disorder;Testing;Therapeutic;therapeutic target;tool;Toxic effect;transcription factor;Translational Research;United States National Institutes of Health;Validation;Withdrawal;Work

PROJECT_TITLE: Small molecule modulators of ΔFosB

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Microbiome;Nutrition;Sleep Research;Substance Misuse

PI_NAMEs: BROWN, JONATHAN MARK (contact)

PROJECT_TERMS: Address;Alcohol abuse;Alcohol consumption;Alcoholic Fatty Liver;Alcoholic Liver Diseases;Alcohols;Amines;biobank;Cardiovascular Diseases;Carnitine;Choline;Chronic Kidney Failure;Chronotherapy;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;cohort;Communication;Communities;Cues;Data;Development;Diabetes Mellitus;Diet;Disease;Drug Targeting;Environment;Environmental Risk Factor;Enzyme Inhibitor Drugs;Enzymes;Ethanol;Fatty acid glycerol esters;fatty liver disease;Feces;FMO3;Food;FRAP1 gene;Funding;G-Protein-Coupled Receptors;Genome;Germ-Free;Grant;gut microbes;gut microbiome;Hepatic;Homeostasis;Homo sapiens;host microbiota;Human;Human body;human disease;inhibitor;integrated circuit;Intestines;Knowledge;Lecithin;Levocarnitine;Link;Liver;liver development;Liver diseases;liver injury;Lyase;Malignant Neoplasms;Microbe;microbial;Micronutrients;mouse model;Mus;Muscular Atrophy;mutant;Mutate;National Institute on Alcohol Abuse and Alcoholism;non-alcoholic fatty liver;Nutrient;Obesity;Organism;Oxides;Pathogenesis;Pathway interactions;Patients;Peripheral;pharmacologic;Production;R24;receptor;Research Personnel;resident commensals;sarcopenia;Signal Transduction;skeletal muscle metabolism;skeletal muscle wasting;small molecule;symbiont;Testing;Therapeutic;Time;tissue injury;Tissues;transmission process;Transplantation

PROJECT_TITLE: Project 1 Title: Gut microbial metabolites as drivers of ethanol-induced liver injury


NIH_SPENDING_CATS: Emerging Infectious Diseases;Hematology;Infectious Diseases;Orphan Drug;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE: Human babesiosis is an emerging and potentially lethal infectious disease caused by eukaryotic pathogens of the genus Babesia. In our search for more potent and safer antibabesial drugs, we discovered that the clinically approved and safe antihypertensive drug fosinopril is a potent inhibitor of Babesia parasites in vitro and in animal models of babesiosis infection. Our proposed studies aim to develop analogs of this drug, determine their mode of action, and conduct efficacy studies to identify candidate drugs that could be advanced toward future clinical evaluation.

PI_NAMEs: BEN MAMOUN, CHOUKRI  (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adverse event;Affect;analog;Angiotensin-Converting Enzyme Inhibitors;Animal Model;Anti-Hypertensive Agents;atovaquone;Azithromycin;Babesia;Babesia microti;Babesiosis;Biochemical;Biological Assay;Biological Availability;Black-legged Tick;Blood Transfusion;Borrelia microti;Bortezomib;candidate identification;Case Study;Chemicals;Clindamycin;Clinical;Clinical Trials;Combined Modality Therapy;Communicable Diseases;Data;Dermacentor;design;Development;Dipeptidyl Peptidases;Disease;Dose;drug candidate;Drug Combinations;Drug Kinetics;Drug usage;effective therapy;efficacy study;Erythrocytes;esterase;Esters;Failure;FDA approved;Formulation;Future;Genetic;Genetic study;Goals;Growth;Human;human model;Hybrids;In Vitro;in vitro testing;in vivo;Infection;inhibitor;Knowledge;Libraries;Link;Malaria;Mass Spectrum Analysis;mouse model;multicatalytic endopeptidase complex;Mus;mutant;Parasites;Parents;pathogen;Peptide Hydrolases;peptidyl-dipeptidase Dcp;Pharmaceutical Preparations;Pharmacodynamics;pre-clinical;Prodrugs;Property;Proteasome Inhibitor;Pyrimethamine;Quinine;rational design;Recrudescences;Regimen;Reporting;research clinical testing;Resistance;Route;Safety;Serum;side effect;Specificity;Structure;Structure-Activity Relationship;success;System;Therapeutic;Therapeutic Index;tick-borne;Ticks;transmission process;Treatment Failure;Treatment Protocols;United States

PROJECT_TITLE: Fosinopril analogs for the treatment of human babesiosis

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE American Indian adults have a high burden of Alzheimer’s Disease and Related Dementias- related comorbidities, however, bilingualism—also common among American Indian peoples and communities—may improve cognition and reduce risk. This project will build on the Strong Heart Study, a 30-year cohort of American Indian adults, in coordination with ongoing efforts funded by NHLBI, to assess the broad and heterogeneous continuum of bilingualism in American Indian peoples by culturally adapting the Language History Questionnaire; examine bilingualism in an estimated 2,500 American Indians in association with measures of fluid and crystallized cognition from the NIH Toolbox Cognition Battery, physical and mental status, and cultural factors; and construct conceptual models of intervariable relationships of bilingualism with cognition, including moderation by crystallized cognition. This study will illuminate a major public health concern in an understudied population.

PI_NAMEs: BARBOSA-LEIKER, CELESTINA  (contact);SUCHY-DICEY, ASTRID M

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Acculturation;Adult;Affect;Age;Aging;Alzheimer's disease related dementia;American;American Indian community;American Indian Population;American Indians;attentional control;bilingualism;cerebrovascular;cofactor;Cognition;Cognitive;cognitive performance;cognitive reserve;cognitive testing;cohort;Communities;community advisory board;comorbidity;Crystallization;Data Collection;Dementia;Diagnosis;Education;Educational Status;experience;federal policy;Funding;Future;General Population;Generations;Geographic Locations;Heart;human old age (65+);Impaired cognition;improved;Individual;instrument;Interview;Language;Link;Liquid substance;Measurement;Measures;mental state;Modeling;Modification;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;performance tests;Population;Population Study;Prevalence;Prevention strategy;protective factors;psychologic;Public Health;Punishment;Questionnaires;Recording of previous events;recruit;Research;response;rho;Risk;Risk Reduction;Role;Schools;sex;Short-Term Memory;skills;social;Socioeconomic Status;Standardization;treatment strategy;United States;United States National Institutes of Health;Vocabulary;Vulnerable Populations;Work

PROJECT_TITLE: Bilingualism as a protective factor of ADRD in American Indian adults: the Strong Heart Study


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Interstitial Cystitis;Pain Research;Urologic Diseases

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Interstitial cystitis/bladder pain syndrome (IC/BPS) represents a potentially life-long chronic pain disorder that is challenging to diagnose, difficult to treat, and often results in a severely diminished quality-of-life. In this pilot and feasibility clinical trial, we will evaluate the safety and efficacy of a non-invasive therapeutic strategy, pulsed electromagnetic field (PEMF) therapy, for pain management in IC/BPS patient subgroups. The goal is to provide preliminary data that will lead to large, hypothesis-driven, multi-center clinical trials.

PI_NAMEs: WALKER, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Adult women;Analgesics;Anesthetics;antinociception;Area;Bladder;Brief Pain Inventory;Characteristics;chronic painful condition;chronic pelvic pain;Clinic;Clinical Trials;Cognitive;cohort;comparison group;Controlled Clinical Trials;Cystectomy;Data;Databases;Degenerative polyarthritis;Devices;Diagnosis;diaries;Disease;Double-Blind Method;Electrocoagulation;Electromagnetic Fields;Enrollment;Exclusion Criteria;Exhibits;experience;Fibromyalgia;Flare;follow-up;Frequencies;Goals;Home;Inflammatory;Injections;Interstitial Cystitis;Intervention;Investigation;Lesion;Maintenance;Microcirculation;Mission;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;Numeric Rating Scale;Opioid Analgesics;Outcome Measure;Pain;Pain management;pain perception;pain reduction;pain score;Patient Recruitments;patient subsets;Patients;Pelvic Pain;Pelvis;Phenotype;Physiologic pulse;Placebo Control;placebo controlled study;placebo group;primary outcome;Process;Publishing;Quality of life;Questionnaires;Randomized;recruit;Regenerative capacity;regenerative tissue;Regimen;Registries;Research Design;response;Rheumatoid Arthritis;Risk;Safety;safety testing;secondary outcome;Site;Symptoms;Syndrome;Testing;Therapeutic;Training;treatment duration;treatment group;Treatment Protocols;Urologist;women patients;Work

PROJECT_TITLE: Investigation of Non-Invasive Pulsed Electromagnetic Field (PEMF) Therapy for Female Patients with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PROVIDENCE

ORG_NAME: WOMEN AND INFANTS HOSPITAL-RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE The overarching goal of this application is to leverage the exceptional clinician-scientists, research infrastructure, NICU Follow-up Program and diverse patient population of the Women and Infants Hospital of Rhode Island (WIH) to make important contributions to the Neonatal Research Network (NRN). Our current application highlights the significant contributions we have made to improving the outcomes of critically ill newborns since we joined the Network in 1991, and important changes we have made to our program and team of investigators to best invigorate and innovate our site. We aim to perform rigorous, systematic, multicenter studies to expand the evidence base for treatment of preterm and term infants and look forward to collaborating and data sharing with a broad range of centers across the Unites States as we work towards achieving the shared goal of improving healthcare and outcomes for newborns.

PI_NAMEs: MARON, JILL LAMANNA (contact)

PROJECT_TERMS: 7 year old;Affect;Area;Behavioral;Biological Markers;Caring;Childhood;Clinical;Clinical Management;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Network;Collaborations;Critical Illness;critically ill newborn;data sharing;design;Development;Diagnostic tests;early childhood;evidence base;Evidence based treatment;experience;Family;follow-up;Foundations;Genomics;Goals;Healthcare;high risk;Home;Hospital Costs;hospitalization rates;Hospitals;Image;improved;improved outcome;Infant;Infusion procedures;innovation;Intensive Care;Leadership;Link;Magnetic Resonance Imaging;Massachusetts;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;Measures;Mission;Morbidity - disease rate;Mothers;Multicenter Neonatal Research Network;Multicenter Studies;Multicenter Trials;National Institute of Child Health and Human Development;Neonatal;Neonatal Intensive Care Units;neurobehavior;Newborn Infant;novel;novel marker;Outcome;Outcome Study;outreach;patient population;Perinatal;perinatal medicine;Physicians;Pregnancy;premature;Premature Infant;preterm newborn;Productivity;prognostic assays;programs;Protocols documentation;Reproducibility;Research;Research Infrastructure;Research Personnel;Rhode Island;Scientist;Sepsis;Site;Solid;Term Birth;United States;Woman;Work

PROJECT_TITLE: NICHD Neonatal Research Network


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Clinical Research;Neurosciences;Prevention;Substance Misuse;Substance Misuse Prevention

PI_NAMEs: DAVALOS, DIMITRIOS  (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Adaptor Signaling Protein;Adolescent;Adolescent and Young Adult;Adult;Affect;Age;Alcohol abuse;alcohol behavior;alcohol effect;alcohol exposure;alcohol prevention;alcohol response;Alcohol-Induced Neurotoxicity;Alcohols;Animal Behavior;Behavior assessment;behavioral impairment;binge drinking;Biological Process;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Proteins;blood-brain barrier disruption;Brain;Brain region;brain tissue;Brush Border;Cell Nucleus;Cells;Central Nervous System;Chronic;Clinical;cytokine;Data;design;Development;drinking;Encephalitis;Endothelial Cells;Ethanol;Fibrinogen;Frequencies;Future;Genes;Genetic Transcription;glial activation;Hemorrhage;Hippocampus;Histologic;Human;human tissue;imaging modality;Immune;impaired brain development;Impairment;in vivo;in vivo imaging;Individual;Induced Neurons;Inflammatory;Knockout Mice;Knowledge;Macrophage;Mediating;Microglia;Modeling;Molecular;monocyte;Morphology;mouse model;Mus;Mutation;Nature;neuroinflammation;neuron loss;Neurons;neurotoxic;novel;Pathology;Pathway interactions;Patients;Play;Population;pre-clinical;Predisposition;preference;Prefrontal Cortex;prevent;Prevention strategy;Property;Reactive Oxygen Species;regional difference;Signal Transduction;single nucleus RNA-sequencing;Synapses;Technology;Testing;Time;tissue injury;Tissues;TLR4 gene;transcriptomics;two photon microscopy;Visual Cortex

PROJECT_TITLE: Project 2 Title: The brain brush border and microglial activation in response to ethanol


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases;Women's Health Research

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: NARRATIVE These studies will determine the extent to which macropinocytosis drives tumor growth and therapeutic resistance using pre-clinical metastatic breast cancer models. Completing these studies will clarify whether agents that limit macropinocytosis could have value as single agents or should be deployed in combination with other therapies. This work will also fill critical gaps in our knowledge of the signals that regulate macropinocytosis in solid tumor cells.

PI_NAMEs: EDINGER, AIMEE L (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Address;Amino Acids;Anabolism;androgen independent prostate cancer;Anthracycline;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Antineoplastic Agents;Autophagocytosis;Bladder;Blood;Blood Vessels;Breast;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;cancer cell;Cancer Patient;cancer therapy;Carbohydrates;Cell Death;Cell Physiology;Cells;Cessation of life;Chemicals;chemotherapy;Clinical;Collecting Cell;Colon Carcinoma;Colorectal;combination cancer therapy;Combined Modality Therapy;Consumption;Data;defined contribution;Dependence;Digestion;disabled;Drug resistance;Drug Targeting;Effectiveness;Epidermal Growth Factor Receptor;Equilibrium;extracellular;Extracellular Protein;Failure;FDA approved;Genetic;Goals;Growth;Immune;Immune checkpoint inhibitor;in vivo;Inflammatory;inhibitor;Innate Immune System;innovation;interstitial;Knowledge;KRAS2 gene;Lipids;Lung;Lysosomes;macromolecule;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;Metastatic breast cancer;Molecular;Mutation;Necrosis;Neoplasms in Vascular Tissue;neoplastic cell;novel;nucleotide metabolism;Nucleotides;Nutrient;Oncogenes;Oncogenic;Outcome;Pancreas;Pathway interactions;Patients;Pattern;PIK3CG gene;Play;pre-clinical;preservation;pressure;Prevalence;prevent;Process;Productivity;Proliferating;prostate cancer cell;Proteins;Proto-Oncogene Proteins c-akt;Publishing;Recycling;Research;response;Risk;Role;Side;Signal Transduction;Solid Neoplasm;Source;standard of care;Starvation;Stream;Supporting Cell;targeted cancer therapy;Testing;Therapeutic;therapeutic target;therapy resistant;tool;trafficking;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor metabolism;tumor microenvironment;tumor progression;Tumor Promotion;tumor-immune system interactions;WNT Signaling Pathway;Work

PROJECT_TITLE: Defining the role of macropinocytosis in solid tumor growth and therapeutic resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-D(02)M]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Sarcopenia;Substance Misuse

PI_NAMEs: DASARATHY, SRINIVASAN  (contact)

PROJECT_TERMS: Adverse effects;Affect;alcohol effect;alcohol exposure;alcohol response;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcohols;Amino Acids;Ammonia;Antioxidants;Autophagocytosis;Biological Assay;Biopsy;Butyrates;Clinical;clinically relevant;clinically significant;Complex;complex IV;Cysteine;Data;Defect;demethylation;effective therapy;Electron Transport;Essential Amino Acids;Ethanol;Fasting;Foundations;FRAP1 gene;Free Radicals;Funding;gain of function;Generations;Goals;Human;human subject;Hyperammonemia;Impairment;improved;In Vitro;in vivo;Infusion procedures;inhibitor;Intervention;Kinetics;Leucine;Lipids;loss of function;Mediating;Metabolic;metabolomics;methyl butyrate;Methylation;Mitochondria;mitochondrial dysfunction;Modeling;Modification;Molecular;multimodality;Mus;Muscle;Muscle Fibers;muscle form;Muscle Mitochondria;Muscle Proteins;Muscular Atrophy;Nitrogen;novel therapeutic intervention;novel therapeutics;Outcome;Oxidation-Reduction;Oxygen Consumption;Pathway interactions;Patients;Phenotype;phosphatase inhibitor;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphotransferases;Plasma;Post-Translational Protein Processing;Pre-Clinical Model;preclinical study;Property;Protein Biosynthesis;Protein Dephosphorylation;Protein Isoforms;Protein Kinase;Protein phosphatase;Proteins;Proteolysis;Proteomics;proteostasis;proteostasis loss;Regulation;Reporting;Respiratory Chain;response;sarcopenia;Signal Transduction;Signaling Molecule;Skeletal Muscle;skeletal muscle wasting;stressor;Testing;tissue injury;Tracer;transcriptome sequencing;Transferase

PROJECT_TITLE: Project 3 Title: Sarcopenia of ALD: regulation of skeletal muscle autophagy by alcohol


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Social Determinants of Health;Telehealth;Tobacco;Tobacco Smoke and Health

ORG_CITY: Newark

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE This study addresses gaps in knowledge and care delivery related to implementation of shared decision making for lung cancer screening with low-dose CT (LDCT) consistent with national guidelines. The research team will conduct a randomized trial to evaluate whether a workflow aware, telemedicine decision coaching and nurse navigation intervention improves quality decision making, adherence with screening and diagnostic testing, and referrals for smoking cessation. With well over 10 million US adults eligible for LDCT, there is a high potential for reducing the burden of lung cancer among heavy smokers by supporting high-quality decision making about LDCT and smoking cessation.

PI_NAMEs: HOFFMAN, RICHARD MICHAEL;KINNEY, ANITA Y. (contact);VOLK, ROBERT J

PROGRAM_OFFICER_NAME: BRUNO, FERNANDO PEREIRA

PROJECT_TERMS: Address;Adherence;Adult;Age;Awareness;black men;Cancer Burden;Cancer Etiology;cancer risk;care delivery;Caring;Cessation of life;Characteristics;Clinical;Cluster randomized trial;comparison intervention;computed tomography screening;Conflict (Psychology);cost;Counseling;Death Rate;Decision Aid;Decision Making;Diagnosis;Diagnostic Procedure;Diagnostic tests;Disparity;disparity reduction;distrust;effective intervention;effectiveness testing;effectiveness/implementation hybrid;Eligibility Determination;ethnic diversity;Ethnic Origin;Exclusion;expectation;experience;feasibility testing;follow-up;Goals;Guidelines;Health Personnel;Health Services Accessibility;high risk;hybrid type 1 trial;implementation evaluation;improved;Incidental Findings;Individual;interest;Intervention;Knowledge;Longitudinal Studies;low dose computed tomography;Lung;lung cancer screening;Malignant neoplasm of lung;Medical;meetings;Methods;Minority;Modeling;mortality;novel strategies;Nurses;Pathway interactions;Patient Care;patient engagement;patient navigation;Patients;Persons;Policy Maker;Population Heterogeneity;Practical Robust Implementation and Sustainability Model;Primary Care;primary care clinician;primary care practice;primary care setting;primary outcome;Provider;Quality of Care;quitline;Race;racial diversity;Radiation exposure;randomized trial;Recommendation;Recording of previous events;Reporting;Research;Resources;screening;screening guidelines;screening services;shared decision making;Smoker;Smoking;smoking abstinence;smoking cessation;social stigma;socioeconomics;System;telehealth;Telemedicine;Testing;Time;Tobacco;tobacco control;Tobacco use;Training;treatment as usual;trial design;Trust;Uncertainty;Underserved Population;United States Preventative Services Task Force;uptake;Woman;X-Ray Computed Tomography

PROJECT_TITLE: TELEhealth Shared decision-making COaching for lung cancer screening in Primary care (TELESCOPE)

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: Maternal alcohol abuse during pregnancy can result in a range of physical, mental, behavioral and learning disabilities termed as Fetal Alcohol Spectrum Disorders. Efforts to successfully prevent or ameliorate the deleterious effects of maternal alcohol consumption have been impeded in part by a limited understanding of alcohol’s complex mechanisms of action involving multiple organ systems. The proposed R01 studies are designed to identify novel etiological molecular pathway(s) for FASD cardinal outcomes using integrative physiologic approaches.

PI_NAMEs: RAMADOSS, JAYANTH  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 3-Dimensional;Affect;Agonist;Alcohol abuse;alcohol abuse during pregnancy;Alcohol consumption;alcohol exposure;Alcohols;Animal Model;Arteries;Arteriographies;ascending aorta;basilar artery;Behavioral;Biological Availability;Biological Markers;Blood flow;Body System;Brain;Cephalic;cerebrovascular;Cerebrum;Child;Complex;cost;cost estimate;Data;design;Development;disease model;Electrophysiology (science);Endothelium;Ethanol Metabolism;Etiology;experimental study;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Growth;Fetal Growth Retardation;FRAP1 gene;Functional disorder;Future;Grant;Growth;Growth Disorders;High Pressure Liquid Chromatography;human model;Image;Immunofluorescence Immunologic;Impairment;improved;In Vitro;in vivo;indexing;Individual;insight;Learning Disabilities;Lecithin;Lifelong disability;maternal alcohol use;Measures;Mediating;Mediator;Microspheres;middle cerebral artery;Modeling;Molecular;Molecular Target;Morphology;Myography;Neurobiology;neurodevelopment;Neurodevelopmental Deficit;neuron development;Neurons;Nitric Oxide;NOS3 gene;novel;Nutrient;Organ;Outcome;Oxygen;patch clamp;Pathway interactions;pharmacologic;Phenotype;Phosphatidic Acid;phosphatidylethanol;Physiological;Play;Positioning Attribute;pregnant;pressure;prevent;Prevention;Preventive;Production;Psyche structure;Rattus;Reporting;Reverse Transcriptase Polymerase Chain Reaction;Role;School-Age Population;Signal Transduction;Societies;System;Teratogenic effects;therapy design;Tissues;Toothache;transcriptome sequencing;ultrasound;United States;Uterus;Vasodilation;Western Blotting

PROJECT_TITLE: A Novel Mechanistic Framework for FASD Etiology.

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Maternal Health;Maternal Morbidity and Mortality;Neurosciences;Physical Injury - Accidents and Adverse Effects;Pregnancy;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: Relevance Maternal birth injury clearly contributes to the development of pelvic floor disorders, yet we possess an incomplete understanding of the impact of maternal pelvic support adaptations, birth injury, and injury recovery on pelvic floor support. Using the novel approach of magnetomyography, our project will combine clinical, anatomic, and physiologic endpoints to improve our knowledge of maternal pelvic muscular adaptations and injury recovery patterns.

PI_NAMEs: ESWARAN, HARI  (contact);OLIPHANT, SALLIE SHERROD

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Address;Adult women;Affect;Anatomy;antenatal;Biomedical Engineering;Birth;Birth trauma;Bladder Control;Brain;Cesarean section;Classification;Clinical;clinical predictors;clinically significant;cohort;Complex;Data;Detection;Development;Discipline of obstetrics;disorder risk;Early Diagnosis;Electromagnetic Fields;Electromyography;Electrophysiology (science);Event;experience;Fecal Incontinence;Female;fetal;First Pregnancy Trimester;Future;Goals;Gravid;High Risk Woman;Human;imaging study;improved;Injury;injury prevention;injury recovery;innovation;innovative technologies;insight;Institution;Intestines;Knowledge;levator ani muscle;long-term sequelae;Magnetic Resonance Imaging;Maps;Measures;Methodology;Methods;models and simulation;multidisciplinary;Muscle;Muscle Contraction;National Institute of Biomedical Imaging and Bioengineering;neuromuscular;neuromuscular function;novel;novel strategies;Nulliparity;Organ;Participant;Pathway interactions;Pattern;Pelvic Floor Disorders;Pelvic Floor Muscle;Pelvic floor structure;pelvic organ prolapse;Pelvis;Physiological;Postpartum Period;Predisposition;Pregnancy;Pregnancy Trimesters;pregnant;prevent;primipara;Protocols documentation;Proxy;Recovery;reproductive;Research;Research Project Grants;response;Risk;Severities;signal processing;Signal Transduction;Skeletal Muscle;soft tissue;Soft Tissue Injuries;sphincter ani muscle structure;Stretching;Symptoms;System;Techniques;Technology;Third Pregnancy Trimester;Time;tool;Trauma;ultrasound;Urinary Incontinence;Uterine Contraction;Uterus;Vagina;Vaginal delivery procedure;Woman;Work

PROJECT_TITLE: Development of Analysis Tools to Enhance Magnetomyographic Assessment of Pelvic Floor Muscles


NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE There are ~1,500 patients in the United States with autosomal recessive polycystic kidney disease (ARPKD), a hepatorenal fibrocystic disorder due to mutations in PKHD1. Our proposed studies aim to understand how mice with Pkhd1 mutations have minimal kidney disease, while human patients with either missense or truncating PKHD1 mutations have severe renal cystic disease. This research has the potential to reveal novel, therapeutic strategies that can attenuate human PKHD1-related renal cystic disease.

PI_NAMEs: CALDOVIC, LJUBICA MORIZONO (contact);GUAY-WOODFORD, LISA MARIE

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Address;Affect;ATP12A gene;Attenuated;Autosomal Dominant Polycystic Kidney;Autosomal Recessive Polycystic Kidney;Biliary;Binding;C-terminal;Cell membrane;Compensation;Cyst;Cystic Kidney Diseases;Data;Disease;disease phenotype;Duct (organ) structure;Engineering;Exons;experimental study;Foundations;Gene Expression;Gene Family;Genes;Genetic;Genetic Models;Genetic Transcription;Human;human disease;in vivo;infancy;Infant;insight;Integral Membrane Protein;integrated circuit;Kidney;Kidney Diseases;Liver Fibrosis;loss of function;Messenger RNA;Modeling;mouse genetics;Mus;Muscular Dystrophies;mutant;Mutant Strains Mice;Mutation;MYC Family Protein;notch protein;novel;Nuclear;Outcome;overexpression;Pathogenesis;Pathway interactions;Patients;Perinatal;Phenocopy;Phenotype;Phylogenetic Analysis;promoter;protein protein interaction;Proteins;Regulation;renal epithelium;Renal function;Research;Role;Severity of illness;Survivors;Testing;Therapeutic;therapeutic target;trafficking;Transcriptional Regulation;Translating;United States

PROJECT_TITLE: Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-H(04)]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Machine Learning and Artificial Intelligence;Nanotechnology;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative All cells dynamically excrete into circulation nano-sized packages called extracellular vesicles (EVs), but this pathway can be hijacked by cancer cells for means of immune system suppression and metastasis. Innovative cross-disciplinary engineering methods are urgently needed to realize the diagnostic application of circulating cancer EVs to improve early detection of diseases like ovarian cancer, which do not have effective early screening tests. This project encompasses the design of highly multiplexed new nanoplasmonic probes for sensitive chemical fingerprinting of targeted circulating EVs, to ultimately improve the limit of detection for diagnosing ovarian cancer compared to conventional methods.

PI_NAMEs: CARNEY, RANDY  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;Antibodies;antigen binding;Architecture;Area;Bar Codes;Binding;Biocompatible Materials;Biological;Biological Assay;Biological Markers;biomarker evaluation;biomaterial compatibility;biosignature;Blood;Blood Circulation;CA-125 Antigen;cancer biomarkers;cancer cell;Cancer Detection;cancer drug resistance;Cancer Patient;Cancer Prognosis;cancer type;Cells;chemical fingerprinting;Chemicals;circulating biomarkers;Circulation;Clinical;clinical application;Communities;cost;Coupling;design;Detection;detection limit;Development;Diagnosis;Diagnostic;diagnostic biomarker;Diagnostic Neoplasm Staging;diagnostic platform;diagnostic technologies;Disease;Early Diagnosis;early screening;Engineering;Enzyme-Linked Immunosorbent Assay;Excretory function;exosome;experimental study;Extinction;extracellular vesicles;Fingerprint;Genes;Goals;Gold;Heterogeneity;Human;Hybrids;Immune system;improved;innovation;Libraries;Ligands;Lipids;liquid biopsy;Liquid substance;Literature;Logic;Machine Learning;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Methods;minimally invasive;Modality;Modeling;Molecular;Monitor;multiplex detection;multiplexed imaging;Multivariate Analysis;nanoparticle;nanoplasmonic;nanoscale;nanosized;Nanostructures;Neoplasm Metastasis;neoplastic cell;new technology;next generation;novel;Optics;Outcome;Parents;particle;Pathology;Pathway interactions;Patients;Peptides;Phenotype;Physicians;Plasma;plasmonics;Play;Population;Process;Property;Proteins;Raman Spectrum Analysis;rapid diagnosis;recruit;Recurrent tumor;Reporting;Reproducibility;Research;Residual Neoplasm;Resolution;Role;Sampling;Sensitivity and Specificity;Series;Shapes;Silanes;Silicon Dioxide;small molecule;Solid;spectroscopic imaging;Spectrum Analysis;Standardization;Structure;Study Subject;Surface;targeted agent;Techniques;Technology;Testing;Thick;Time;Training;tumor;Tumor Antigens;tumor growth;Untranslated RNA;Validation;Vesicle;vesicle transport;vesicular release;Width;women's diagnosis

PROJECT_TITLE: SERS diagnostics platform for liquid bioapsy analysis of tumor-associated exosomes


NIH_SPENDING_CATS: Pediatric

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVES This project will prepare a new generation of Native Hawaiians and Pacific Islanders in the 7 US State and US- affiliated territories for careers in health and sciences under the One Health umbrella. In doing so, it will also expand and strengthen the science education capacity of Pacific high schools, and research and training at Pacific colleges. Importantly, It will raise community awareness of the intimate connections between the well beings of humans, animals and eco-environment where solutions to improve health for all can be found.

PI_NAMEs: HUI, GEORGE S (contact)

PROGRAM_OFFICER_NAME: BODDIE, THOMAS ARTIS

PROJECT_TERMS: Academic advising;Address;Adopted;Agriculture;Animals;Awareness;Biological Sciences;Burn injury;career;Cell Nucleus;cohort;college;combat;Communities;community based research;cultural values;Databases;Disadvantaged;disadvantaged background;Disease;Education;eleventh grade;Enrollment;Environment;Environmental Science;experience;Federated States of Micronesia;follow-up;Fostering;Fruit;Future;Generations;Goals;Grant;Guam;hands on research;Hawaii;Health;health disparity;Health Promotion Sciences;health science research;Health Sciences;Healthcare;high school;High School Outreach;high school program;High School Student;higher education;Home;Human;improved;Incentives;Individual;instrument;interest;Internships;Island;Knowledge;Laboratories;Laboratory Research;Marshall Islands;medical schools;Mentors;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Native Hawaiian or Other Pacific Islander;natives;next generation;Northern Mariana Islands;Outcome;outreach;Pacific Islands;Palau;Pathway interactions;Personal Satisfaction;Persons;Population;Process;programs;Progress Reports;Qualifying;recruit;Reduce health disparities;Research;Research Project Grants;Research Training;responsible research conduct;Samoa;Schools;Science;science education;Scientist;Shapes;social media;Solid;STEM program;Stress;Students;summer program;summer research;Training;Training and Education;Training Programs;twelfth grade;Underrepresented Students;Universities;US State;Water

PROJECT_TITLE: Pacific High Schools STEP-UP to One Health


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease;Substance Misuse

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PROJECT_TERMS: Affect;Alcohol abuse;alcohol exposure;Alcoholic Liver Diseases;Alcohols;American;Apoptosis;biomarker identification;Bone Marrow Transplantation;Breeding;Caspase;Cell Culture Techniques;Cell Death;Cells;Cessation of life;circulating biomarkers;Clinical;Complex;Coupled;Cytoprotection;Data;Development;Differential Diagnosis;Disease;Environment;Enzyme-Linked Immunosorbent Assay;Ethanol;Family member;Functional disorder;Hepatocyte;High Fat Diet;Immune;in vivo;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;inhibition of autophagy;Injury;insight;Knock-out;Lead;Liver;liver biopsy;Liver diseases;liver inflammation;liver injury;Mediating;Messenger RNA;Methods;MicroRNAs;Mitogen-Activated Protein Kinases;mixed lineage kinase 3;Modeling;Molecular;mouse model;Mus;Myeloid Cells;Natural Immunity;nonalcoholic steatohepatitis;novel;Organelles;Pathway interactions;Patients;Persons;Phosphorylation;Phosphotransferases;Plasma;predictive modeling;Prevention;Process;protein protein interaction;Proteins;Proteome;Proteomics;receptor function;Regulation;Regulatory Pathway;Resolution;RIPK1 gene;RIPK3 gene;Sampling;Signal Transduction;Stress;Therapeutic;therapeutic development;tissue injury;treatment strategy;Ubiquitin;ubiquitin-protein ligase;Ubiquitination

PROJECT_TITLE: Project 4 Title: Innate immunity and cell death in ALD


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative/Relevance  This research is relevant to public health because it addresses the basic molecular mechanisms of how mutations in a brain-specific enzyme, protein kinase C gamma, result in aberrant function to cause the disease spinocerebellar ataxia. This enzyme transduces Ca2+ signals in the brain and understanding the structural basis for how mutations alter its structure and function will inform on potential therapies.

PI_NAMEs: NEWTON, ALEXANDRA C. (contact);TAYLOR, SUSAN S.

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Affect;Ataxia;Automobile Driving;autosome;Biochemical;Brain;Cerebellar Ataxia;Cerebellar Diseases;Cerebellum;Cryoelectron Microscopy;Cyclic AMP-Dependent Protein Kinases;Diglycerides;Disease;disease phenotype;Enzymes;Fluorescence Resonance Energy Transfer;Future;Germ-Line Mutation;Goals;Homeostasis;Isoenzymes;Knowledge;Length;live cell imaging;Malignant Neoplasms;Molecular;Molecular Conformation;Motor;mouse model;mutant;Mutation;Neurodegenerative Disorders;Neurons;novel;Output;Pathology;Pathway interactions;Patients;phosphoproteomics;Phosphotransferases;protein function;protein kinase C gamma;Protein Region;Proteins;Public Health;Purkinje Cells;Quality Control;Regulation;Research;Resolution;sensor;Shunt Device;Signal Pathway;Signal Transduction;Signaling Protein;spatiotemporal;Spinocerebellar Ataxias;Spinocerebellar Degenerations;structural biology;Structure;Therapeutic;transcriptome;transcriptome sequencing;Vision

PROJECT_TITLE: Structural and Molecular Mechanisms for Dysregulation of Protein Kinase C Gamma in Cerebellar Ataxia

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative Inadequate health literacy costs the U.S. economy $100-$200 billion annually, while Justice-involved African American, Black (AAB) and Hispanic adults (JIA) experience inadequate health literacy and structural racism that contributes to disparities in healthcare access and higher rates of acute and chronic conditions. The proposed project uses a longitudinal mixed-methods randomized clinical trial design to test the effectiveness of a coach-guided health literacy intervention (versus a self-study Control Group) to improve JIA’s health literacy and reduce their disparities in healthcare access. The proposed intervention has significant potential for increasing health literacy among JIA and thus improving the well-being of this sizeable and underserved community of >20 million U.S. persons.

PI_NAMEs: OJEDA, VICTORIA D (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: acceptability and feasibility;access disparities;Acute;Address;Adopted;Adult;African American;Age;arm;Attitude;barrier to care;Black Populations;Black race;burden of chronic illness;care systems;Caring;Chronic;Clinical Trials Design;Communicable Diseases;Communities;community collaboration;community partners;community reentry;community setting;comparison control;Control Groups;cost;Data;design;Diffusion;Disparity;disparity reduction;Economics;effectiveness evaluation;effectiveness testing;Ethnic Origin;Evidence based intervention;Exhibits;experience;Face;follow-up;forging;Fortification;Funding;Goals;Health;health care availability;health care disparity;health care service;health care service utilization;Health Care Visit;health disparity;Health Insurance;health literacy;Health Promotion;Health Resources;Health Services;Health Services Accessibility;Healthcare;Hispanic;Hispanic Populations;improved;Individual;Institution;Institutional Racism;Insurance Coverage;Interdisciplinary Study;interest;Intervention;intervention effect;Intervention Studies;Interview;Justice;Knowledge;Longitudinal Studies;low health literacy;Low income;Maintenance;Measures;member;Methods;National Institute on Minority Health and Health Disparities;novel;Outcome;Participant;Perception;Personal Satisfaction;Persons;Pilot Projects;Police;Policies;prevent;primary outcome;programs;racial disparity;Randomized;randomized, clinical trials;recruit;Reduce health disparities;Reporting;Research;Research Personnel;Resources;Sampling;satisfaction;secondary outcome;Self Care;Self Efficacy;Service delivery model;service utilization;Services;skills;social;social contact;Source;Strategic Planning;structural determinants;Structural Racism;Structure;System;Testing;theories;therapy design;Time;treatment arm;treatment group;underserved community;United States National Institutes of Health;Work

PROJECT_TITLE: An RCT Testing a Health Literacy Intervention to Reduce Disparities in Access to Care Among Justice Involved Adults (JIA)


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Narrative: The benefits of cancer screening are uncertain for adults >75 years and there are known harms (e.g., anxiety due to false alarms and diagnosis and treatment of cancers that otherwise would never have caused problems in an older adult's lifetime); therefore, guidelines recommend that cancer screening decisions consider older adults' risk for cancer, 10-year life expectancy, and value and preferences. Yet, many adults >75 years are screened for cancer without being informed of the harms and with little chance of benefit; therefore, Dr. Schonberg's research and mentoring program aims to improve shared decision making around cancer screening among clinicians, older adults, and their involved family members. A NIA K24 would allow Dr. Schonberg to continue to build her patient oriented research program in shared decision making around cancer screening for older adults, to expand her mentorship program to prepare the next generation of aging researchers in shared decision making, and would help ensure broad implementation of her decision support tools thereby improving the care of older adults.

PI_NAMEs: SCHONBERG, MARA A (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adult;Age;Aging;Ancillary Study;Anxiety;Awareness;Breast Cancer Risk Factor;Caliber;cancer risk;cancer therapy;Caregivers;Caring;Cessation of life;Client satisfaction;Colorectal Cancer;colorectal cancer screening;Decision Aid;Dementia;Detection;Development;Diagnosis;Ensure;Family member;Funding;Future;Goals;Guidelines;Habits;Health;implementation science;improved;Incidence;Infrastructure;Intervention;Investigation;Israel;Knowledge;late life;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Mammography;Medical;Medical center;medical schools;Mentors;Mentorship;Modeling;models and simulation;next generation;novel;older adult;older women;Online Systems;Outcome;Output;overtreatment;Paper;Patient Care;patient engagement;patient oriented research;Patient risk;Patients;pilot test;Population;predictive modeling;preference;primary care clinician;Prognosis;programs;randomized trial;randomized, clinical trials;Recommendation;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Resources;screening;Screening for cancer;secondary analysis;shared decision making;skills;support tools;supportive environment;System;Teacher Professional Development;Testing;Time;tool;Training;tumor;Visit;Woman

PROJECT_TITLE: Research and mentoring program in shared decision making in the care of older adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Infectious Diseases;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The role of peroxisome proliferator-activated receptor-delta (PPAR-d) protein in cancer development needs to be defined to generate drugs to either inhibit or stimulate its function. Our proposed research will explore for the first time the role and molecular mechanisms of PPAR-d in gastric tumor development, as well as translational significance of molecular targeting PPAR-d signaling for gastric tumor intervention. The results of this proposal will provide much-needed information for developing new drugs to target this protein for cancer prevention and treatment.

PI_NAMEs: ZUO, XIANGSHENG  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Adenocarcinoma;Adult;Advanced Development;Affect;Agonist;antagonist;Breeding;cancer prevention;cancer stem cell;cancer therapy;carcinogenesis;Carcinogens;CCL20 gene;CCR6 gene;Cell Lineage;Cell Separation;Cells;chemokine;Chronic;Coculture Techniques;Data;delta protein;Development;Enterobacteria phage P1 Cre recombinase;Epithelial Cells;Epithelium;Event;experimental study;Exposure to;Flow Cytometry;gastric cancer prevention;gastric corpus;Gastric Tissue;gastric tumorigenesis;Gastritis;Genes;Genetic;Goals;Harvest;Helicobacter felis;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;Histologic;Human;IFNGR1 gene;Immune;In Vitro;Incidence;Individual;Infiltration;Inflammation;insight;Interferon Type II;Internal Ribosome Entry Site;Intervention;Knockout Mice;Knowledge;LGR5 gene;loss of function;Malignant Neoplasms;malignant stomach neoplasm;Methylnitrosourea;Migration Assay;Modality;Molecular;Molecular Target;mouse model;mRNA Expression;Mus;Muscle;novel;novel therapeutics;overexpression;Pathogenesis;Pathway interactions;patient prognosis;Pharmaceutical Preparations;Population;PPAR delta;prevent;Process;Production;progenitor;Proliferating;promoter;Protein Sortings;Proteins;PTPRC gene;Publishing;receptor;red fluorescent protein;Reporter Genes;Research;Risk Factors;Rodent;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Sorting;stem cell proliferation;stem cells;stemness;Stomach;Stomach Neoplasms;Survival Rate;Tamoxifen;Testing;Time;Tissues;Transgenic Organisms;tumor;Tumor-infiltrating immune cells;tumorigenesis;Up-Regulation;villin

PROJECT_TITLE: Molecular Understanding and Targeting of Determinant Factors in Gastric Tumorigenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Endothelial disease is a leading indication for corneal transplantation in the United States and around the world. Corneal transplantation techniques have evolved and improved rapidly in recent years, but there is no consensus on the best technique; additionally, endothelial cell loss after endothelial keratoplasty remains a concern. Here we propose a randomized clinical trial to evaluate two common selective endothelial keratoplasty techniques and determine the utility of topical rho-kinase inhibitors in preventing endothelial cell loss after corneal transplantation.

PI_NAMEs: ROSE-NUSSBAUMER, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Address;Adjuvant;Anterior;anterior chamber;Apoptosis;arm;California;Cell Count;Cell Density;Cell Proliferation;Cells;cellular imaging;Clinical Trials;Complication;Consensus;Cornea;Corneal edema;cost;Data;Descemet's membrane;design;Disease;Eligibility Determination;Endophthalmitis;Endothelial Cells;endothelial dysfunction;Endothelium;Eye Banks;Eyeglasses;Failure;Fuchs' Endothelial Dystrophy;Funding;Future;graft failure;Graft Rejection;Graft Survival;Health;Health system;high resolution imaging;Human;Image;Imaging Techniques;improved;improved outcome;In Vitro;individual patient;innovation;Keratoplasty;kinase inhibitor;Lamellar Keratoplasty;Maintenance;Maryland;Masks;Medical;meter;Modeling;novel;Operative Surgical Procedures;Ophthalmology;Optics;Oregon;Outcome;Participant;Patients;Penetrating Keratoplasty;Perioperative;Pharmaceutical Preparations;Placebos;Play;Positioning Attribute;Postoperative Period;prevent;Randomized;randomized, clinical trials;Recovery;Research Design;Rho-associated kinase;Risk;Role;Safety;Science;Series;Societies;Surgeon;Techniques;Testing;Therapeutic Exploratory Study;Thick;Time;Topical application;Transplant Surgeon;Transplantation;Transplantation Surgery;treatment group;United States;Universities;Vision;Visual;Visual Acuity

PROJECT_TITLE: Descemet Endothelial Thickness Comparison Trial (DETECT)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Digestive Diseases;Liver Disease;Substance Misuse

PI_NAMEs: MCINTYRE, THOMAS M (contact)

PROJECT_TERMS: Alcohol abuse;alcohol exposure;alcohol research;alcohol response;alcohol use disorder;Alcoholic Liver Diseases;Alcohols;Animal Model;antimicrobial;Applications Grants;Area;Biological Assay;Biological Markers;biomarker development;Brain;Cell model;Cells;Child;Chronic;Clinic;Clinical;clinical investigation;Clinical Investigator;clinical translation;clinically relevant;Collaborations;college;Communities;Complex;Data;depolymerization;Development;developmental neurotoxicity;Disease Progression;Disease susceptibility;Doctor of Philosophy;efficacy evaluation;Elements;Environment;Ethanol;Ethanol Metabolism;exosome;Faculty;Fingerprint;flasks;Functional disorder;Funding;Future;Goals;Grant;gut microbiome;Hepatic;Hepatic Encephalopathy;Human;Individual;innovation;Institution;Kidney Diseases;Magnetic Resonance;Medical center;Medicine;member;Microfilaments;Molecular Target;Monitor;Muscular Atrophy;novel;novel strategies;novel therapeutic intervention;Ohio;organ transplant recipient;Organoids;oxidation;Oxidation-Reduction;Pediatric Hospitals;Pilot Projects;Population;programs;Proteome;Publications;Recovery;Research;Research Personnel;response;Role;Scientist;Sepsis;Sirtuins;success;System;targeted treatment;Testing;Therapeutic Intervention;tissue injury;Tissues;translational scientist;Universities;wound healing

PROJECT_TITLE: Pilot Project Core


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The Neonatal Research Network's high impact research requires active sites with energized, collaborative research teams with innovative ideas. The North Carolina Clinical Center for the Eunice Kennedy Shriver NICHD Neonatal Research Network Clinical Center provides a large and diverse patient population for Network studies from three large independent academic tertiary medical centers and adds a very strong record of working with Network collaborators to 1) develop innovative, multidisciplinary approaches to health problems of newborn infants, and 2) foster early career development of young clinician scientists who will have significant impact on the care of newborns.

PI_NAMEs: COTTEN, CHARLES MICHAEL (contact);LAUGHON, MATTHEW ;MOORE, RYAN THOMAS

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Active Sites;African American;Candidiasis;career;career development;Childhood;Classification;Clinical;clinical center;clinical practice;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Design;Collaborations;collaborative approach;Common Data Element;Communities;community engaged research;Databases;design;Development;DNA Library;Eligibility Determination;Enrollment;environmental enrichment for laboratory animals;experience;Faculty;follow-up;Follow-Up Studies;Fostering;Health;health equity;high risk;Hispanic;imaging biomarker;improved;improved outcome;Incubators;Infant;Infant Care;Infant Health;infant outcome;innovation;Inositol;Institution;interdisciplinary approach;Journals;Lead;Leadership;Link;Low Birth Weight Infant;Manuscripts;Maternal Health;Medical center;Mission;mortality risk;Multicenter Neonatal Research Network;Multicenter Trials;National Institute of Child Health and Human Development;Neonatology;Neurodevelopmental Impairment;neuroimaging marker;new technology;Newborn Infant;next generation;North Carolina;Not Hispanic or Latino;novel;Observational Study;operation;Optical Coherence Tomography;Outcome;Outcome Assessment;Paper;participant enrollment;patient population;Patients;Perinatal;perinatal services;Phase;Phototherapy;Population Heterogeneity;premature;Premature Infant;Process;protocol development;Protocols documentation;Psychologist;Publications;Reporting;Research;Research Design;Research Personnel;Resources;retinal imaging;Review Committee;Scientist;Site;Staff Development;Support Groups;System;Testing;Transfusion;trial design;Universities;Update;Visual Acuity;Vital Statistics

PROJECT_TITLE: North Carolina Clinical Center


PI_NAMEs: CRONIGER, COLLEEN MARIE (contact)

PROJECT_TERMS: Abbreviations;Acute;Acute Hepatitis;alcohol exposure;alcohol research;alcohol response;Alcohols;animal breeding;Animal Model;Animals;Backcrossings;biobank;Biological Assay;Body Weight;Cell model;Cell Separation;Cells;Chronic;clinically relevant;Complex;Consult;Consultations;Cost Savings;Data;Data Analyses;data integration;Databases;design;Development;diet-induced obesity;Eating;efficacious treatment;efficacy evaluation;Endothelial Cells;Ensure;Equipment and supply inventories;Ethanol;experience;Experimental Designs;experimental study;Exposure to;Fibrosis;Funding;Genetic;Genetic Models;Goals;Harvest;Hepatic;Hepatic Stellate Cell;Hepatocyte;Human Resources;Immune;In Vitro;in vivo Model;Injury;innovation;International;Knock-out;Laboratories;Liver;Macrophage;Maintenance;member;Metabolic;Modeling;Molecular;Molecular Target;mouse model;Mus;National Institute on Alcohol Abuse and Alcoholism;novel;novel therapeutic intervention;Ohio;Organ;Pathogenesis;Pilot Projects;Population;Primary Cell Cultures;Procedures;Process;Protocols documentation;Quality Control;Rattus;Research;Research Personnel;Research Project Grants;Research Support;Resources;response;Rodent;Sampling;Sorting;sound;Source;Standardization;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;tissue injury;Tissue Sample;Tissues;treatment strategy

PROJECT_TITLE: Animal Model and Cell Isolation Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Both coding and noncoding RNAs can affect regulatory processes that go awry in Alzheimer’s disease (AD), though until now the focus has been on coding RNAs. Through isolation of synapses in the form of synaptosomes from in AD versus control frontal cortex tissue, we have identified a series of circular RNAs that are differentially expressed in genes critical for AD etiology including in GSK3B and PSEN2. We propose to interrogate the consequences of these circular RNAs to disease pathogenesis and their mechanism of action.

PI_NAMEs: VALDMANIS, PAUL NILS (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: abeta accumulation;Affect;Alternative Splicing;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's Disease Pathway;Alzheimer's disease patient;Amyloid beta-Protein;Biogenesis;Brain;brain tissue;Cell Line;Cells;circular RNA;Code;Complement;design;differential expression;Disease;effective therapy;Etiology;Evaluation;Event;Exons;frontal lobe;Generations;Genes;Genetic Transcription;glycogen synthase kinase 3 beta;glycogen synthase kinase 3 beta inhibitor;High-Throughput RNA Sequencing;Hippocampus;Human;Hypoxia;In Vitro;Individual;Knowledge;Large-Scale Sequencing;Late Onset Alzheimer Disease;Mediating;Messenger RNA;mouse model;mRNA Translation;Neurodegenerative Disorders;Neurons;novel;novel therapeutic intervention;Oxidative Stress;Pathogenesis;Pathogenicity;Pathology;Patients;physiologic stressor;presenilin-2;preservation;Prevalence;prevent;Process;Production;Protein Isoforms;Proteins;Regulation;Regulatory Element;Repetitive Sequence;repository;RNA;RNA Helicase;RNA Splicing;Role;Sampling;Series;Study models;Synapses;Synaptosomes;tau aggregation;tau expression;tau Proteins;tau-1;Testing;Therapeutic;Tissues;Transcript;transcriptome;transcriptome sequencing;Translations;Untranslated RNA;Variant;vector

PROJECT_TITLE: Mechanisms underlying circular RNA biogenesis in Alzheimer’s disease related genes


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project Narrative All physiological processes (including aging) involve processes across different time scales, but how the dynamics relate to the outcome is poorly understood. Without such understanding, it is difficult to engineer strategies of intervention, e.g., to slow age-related diseases. This project aims to build a fundamental understanding of the aging trajectory in an experimental system C. elegans; the approach and insights are likely applicable to aging and other long-term physiological processes in other systems including human.

PI_NAMEs: BERMAN, GORDON JOSEPH;LU, HANG  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: age-related disease;Aging;aging process;aging related;Animal Behavior;Animal Model;Animals;Automobile Driving;Behavior;Behavioral;Biological;Biological Models;Biological Phenomena;Biological Process;biological systems;Brain;Caenorhabditis elegans;Calcium;Cell model;Communities;computational pipelines;Computer software;Cues;Data;data quality;Data Set;data-driven model;design;Development;dimension reduction;dynamic system;Engineering;Environment;Event;experience;experimental study;feeding;Food;Genes;Genetic;Genetic Models;Goals;Health;healthspan;healthy aging;high dimensionality;Human;Image;in vivo;Individual;innovation;insight;instrumentation;Intermittent fasting;Intervention;life span;Link;Longevity;machine learning method;Measurement;Measures;Metabolic;Methods;model organism;Modeling;Mus;mutant;Nematoda;Nervous System Disorder;neural;neural circuit;neurogenetics;neuroimaging;Neurons;Neurosciences;nonhuman primate;Outcome;Output;Pathology;Physiological;Physiological Processes;Physiology;Process;Research;Research Personnel;response;Scheme;sex;System;Techniques;Technology;theories;Time;tool;Work

PROJECT_TITLE: Inferring multi-scale dynamics underlying behavior in aging C. elegans

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_DEPT: CHEMISTRY

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Nucleic acids exhibit inherently unfavorable biopharmaceutical properties due to specific and non-specific interactions with proteins (enzyme stability, immunostimulation, coagulopathy, etc.), which hamper their development as therapeutic agents. Herein, we will investigate a novel mechanism for nucleic acid delivery based upon entropic protection (termed pacDNA), which facilitates duplex formation but disfavors protein binding (generally the first step leading to undesirable non-hybridization side effects). We will investigate and understand the molecular parameters that give rise to the unique properties of the pacDNA, probe its in vivo characteristics in mouse and non-human primates, and demonstrate improved efficacy in preclinical models for Hutchinson-Gilford progeria syndrome over the state-of-the-art.

PI_NAMEs: ZHANG, KE  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: adaptive immunity;Adopted;Affect;Antisense Oligonucleotides;Area;Benign;Binding;Binding Proteins;Biodistribution;Biological Availability;Biological Products;Blood;Blood Coagulation Disorders;Brain;Cell Communication;Cells;Characteristics;Chemicals;Clinical;Clinical Trials;combinatorial;cost;Cytoplasm;delivery vehicle;density;Deposition;design;Development;Disease;disease model;DNA;DNA Structure;dosage;Dose;Drug Kinetics;efficacy evaluation;Endosomes;Endowment;Enzyme Stability;epigenetic regulation;Exhibits;Face;fomivirsen;Frequencies;Funding;Genes;Genetic Diseases;Goals;Heart;Hydrophobicity;immune activation;Immune system;Immunologic Stimulation;improved;in vivo;Injections;insight;Investigation;Kinetics;KRAS2 gene;learning materials;Libraries;Lipids;Liver;Machine Learning;Messenger RNA;Metabolic Diseases;Modality;Modeling;Modification;Molecular;monomer;mRNA Precursor;Mus;Muscle;nanoparticle;neglect;Non-Small-Cell Lung Carcinoma;nonhuman primate;novel;novel strategies;Nuclear;nuclease;nucleic acid delivery;Nucleic Acids;nucleobase;oligonucleotide delivery;oligonucleotide therapeutics;Oligonucleotides;Organ;Peptides;pharmacologic;Philosophy;Plasma;Plasma Enhancement;Polymers;pre-clinical;Pre-Clinical Model;preservation;Progeria;Property;Proteins;Renal clearance function;research clinical testing;Ribonuclease H;RNA;RNA Splicing;Safety;Side;side effect;simulation;Site;Skeletal Muscle;Skin;stem;Structure;Syndrome;System;Technology;Therapeutic;Therapeutic Agents;Thermodynamics;Tissues;tool;Toxic effect;Transcriptional Regulation;Transfection;Translational Repression;Treatment Efficacy;Tumor Suppression;United States Food and Drug Administration;Untranslated RNA;uptake;vector;Vertebral column;Virus Diseases;Xenograft Model

PROJECT_TITLE: Making Oligonucleotides Better Biopharmaceuticals by Steric Protection

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE – OVERALL Liver disease affects nearly one in three Americans. The Yale Liver Center's mission is to enhance knowledge of the etiology, diagnosis and treatment of liver diseases and other related disorders of the digestive system, thereby advancing the nation's public health. It does so by simulating both basic, translational and clinical research in this discipline at the University and by establishing core research facilities for use by multiple liver investigators.

PI_NAMEs: NATHANSON, MICHAEL H (contact);STRAZZABOSCO, MARIO

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Affect;American;Applied Genetics;Area;Autoimmune Diseases;Award;base;Basic Science;bench to bedside;Biochemical;Biochemistry;Biology;Biomedical Engineering;Biophysics;Cellular biology;Cholestasis;Cirrhosis;Clinical;clinical application;Clinical Research;clinically relevant;Collaborations;comparative;Consumption;Core Facility;cost;Diagnosis;Digestive System Disorders;Discipline;Discipline of obstetrics;Disease;Environment;Epidemiology;Epithelium;Etiology;Faculty;Fibrosis;Fostering;Funding;gastrointestinal system;Genetic Diseases;Goals;Grant;Gynecology;Human Genetics;Immunobiology;Individual;Infection;Inflammation;Institution;interest;Internal Medicine;Investigation;Joints;Knowledge;Liver;Liver diseases;liver metabolism;Malignant neoplasm of liver;Medicine;member;microbial;Mission;Molecular;Morphology;multidisciplinary;nonalcoholic steatohepatitis;Nursing Faculty;Operative Surgical Procedures;Organizational Efficiency;Participant;Pathogenesis;Pathology;Patients;Pediatrics;Persons;Pharmacology;Physiological;Physiology;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Procedures;programs;Public Health;Publications;Radiology Specialty;Research;research facility;Research Personnel;Role;Science;Scientist;Structure;symposium;Talents;Techniques;Technology;Time;Training;training opportunity;Translational Research;translational study;Universities;Urology;Visit;Work

PROJECT_TITLE: Yale Liver Center


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

PI_NAMEs: DASARATHY, JAIVIDHYA  (contact)

PROJECT_TERMS: Alcoholic beverage heavy drinker;Alcoholic Hepatitis;Alcoholic Liver Cirrhosis;Alcoholic Liver Diseases;Alcohols;Archives;Basic Science;biobank;Biological;Biological Assay;biological specimen archives;Biological Specimen Banks;Biopsy;Biopsy Specimen;case history;circulating biomarkers;Clinic;Clinical;Clinical Data;Clinical Distribution;Clinical Investigator;clinical practice;Clinical Research;clinically relevant;Communication;Data;data acquisition;Databases;Development;Diagnosis;Diagnostic;Disease;DNA;Ensure;Ethanol;Feces;follow-up;Genetic Polymorphism;Goals;Heavy Drinking;Histologic;Human;Immune;Individual;Institutional Review Boards;Liver;Liver diseases;Medical center;member;Minority Groups;minority patient;Morbidity - disease rate;mortality;Mus;nonalcoholic steatohepatitis;novel;Obesity;Ohio;Pathologic;Pathologist;Patient Recruitments;Patients;Peripheral Blood Mononuclear Cell;Pilot Projects;Plasma;Protocols documentation;recruit;Research;Research Personnel;Resources;sample collection;Sampling;Serum;Severity of illness;specific biomarkers;Teaching Hospitals;Testing;Therapeutic Intervention;Thinness;tissue injury;Tissues;Translations;treatment response;Universities;Urine;Work

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Infectious Diseases;Vector-Borne Diseases

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: KENYATTA UNIVERSITY

PHR: NARRATIVE PZQ monotherapy is used to treat schistosome infection, and so evolution of PZQ resistance is a major concern, and new drugs are urgently needed. We have developed a unique platform that I will use to examine drug response in individual field derived schistosomes. This will allow us to (i) examine the prevalence of PZQ resistance in the field and their contribution to treatment failure, (ii) to determine the genome regions underlying resistance, (iii) to determine the genes underlying resistance to other schistosome drugs under development.

PI_NAMEs: NDOMBI, ERIC MAKUTO (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: Adult;Africa;African;Anthelmintics;Area;Biological Assay;Biomphalaria;Breeding;Caenorhabditis elegans;chemotherapy;Collaborations;Communities;Computational Biology;Country;Development;Disease;Drug Delivery Systems;Drug resistance;Drug Screening;egg;Evolution;Exposure to;Failure;field study;Genes;Genetic;genetic analysis;Genetic Variation;Genome;genome sequencing;genomic data;Genomic Segment;Genomics;Goals;Hamsters;Harvest;hatching;Helminths;In Vitro;Individual;individual response;Infection;Infrastructure;Kenya;Knowledge;Laboratories;Larva;male;Measures;Methods;Natural Resistance;Nematoda;novel;novel therapeutics;Parasite resistance;Parasites;Patients;Perfusion;Pharmaceutical Preparations;Pharmacology;Phenotype;phenotypic data;Population;Praziquantel;Praziquantel resistance;Predisposition;Prevalence;Recommendation;Research;research and development;Resistance;response;scale up;Schistosoma;Schistosoma mansoni;Schistosome Parasite;Schistosomiasis;Site;Snails;stool sample;Target Populations;Testing;tool;Treatment Failure;treatment program;TRP channel;Variant;whole genome;Work;World Health Organization

PROJECT_TITLE: Characterisation of drug resistance in field-collected schistosomes