NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Alzheimer’s disease is a major public health concern that continues to increase in severity given the aging population. It is also a condition that disproportionately affects minority populations, who have reduced access to healthcare and may have distinguishable risk factors including cerebrovascular risk. The goal of this project is to establish the role of cerebrovascular injury and dysfunction in the pathophysiology of preclinical Alzheimer’s and develop individualized imaging-based cerebrovascular profiles that predict memory decline across racially and ethnically diverse populations.

PI_NAMEs: YASSA, MICHAEL A (contact)

PROJECT_TERMS: Address;Adopted;Adverse event;Affect;African American population;Age;Age Years;Aging;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Amyloid;asymptomatic Alzheimer's disease;Award;Awareness;Biological Markers;Black Populations;Black race;Blood Pressure;Blood Vessels;Brain;brain dysfunction;Brain imaging;Brain Injuries;Cardiovascular Diseases;caucasian American;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;cerebrovascular reactivity;Chronic;Classification;Clinical;clinical outcome assessment;Clinical Research;Clinical Trials;Cognitive;cognitive testing;cohort;community partnership;Complement;Data;Dementia;Deterioration;Development;Diffusion Magnetic Resonance Imaging;digital;Discrimination;Education;Enrollment;ethnic disparity;ethnic diversity;Ethnic Population;Etiology;Exclusion;Female;fitness;follow up assessment;Functional disorder;Future;Gases;Goals;Health;health care availability;health disparity;Hemorrhage;high dimensionality;high risk;Hippocampus;Hispanic;Hispanic Populations;Image;Imaging Techniques;Impaired cognition;Income;Individual;Infrastructure;Injury;innovation;insight;Intervention;Intervention Trial;Latino;Latino Population;Life Style;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;Maps;medial temporal lobe;Mediating;Memory;Memory Loss;Minority Groups;Minority Recruitment;Modeling;modifiable risk;Multimodal Imaging;multimodality;Natural History;Neighborhoods;neural;Neurobiology;Neuronal Dysfunction;Neuropsychological Tests;non-demented;novel;novel marker;Obesity;Observational Study;Occupations;older adult;Outcome Measure;Paper;Participant;Pathogenesis;Patients;Pattern;Performance;Physical activity;Population;Population Heterogeneity;Positron-Emission Tomography;pre-clinical;precision medicine;Predisposition;Prevalence;primary outcome;Public Health;Publications;racial disparity;racial diversity;racial population;Recording of previous events;recruit;Resolution;Rest;Risk;Risk Factors;risk prediction;Role;Sampling;secondary outcome;Severities;Sleep;social health determinants;social stress;Social support;sound;Statistical Models;Stroke;structural determinants;Structure;Sum;tau aggregation;tau Proteins;Testing;Thick;Vascular Dementia;Vascular Diseases;White Matter Hyperintensity;Work

PROJECT_TITLE: Assessing the role of cerebrovascular brain injury and dysfunction in Alzheimer’s disease pathogenesis in the BEACoN Cohort

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Lung

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project will develop new volumetric magnetic resonance imaging technology for the detection of dynamic airway problems, and for guiding invasive procedures in the heart. It will also form a strategic partnership between NIH and USC to develop technology for MRI at the novel field strength 0.55 Tesla that could provide better images of the heart, lungs, and airway, while being safer and quieter than current MRI systems.

PI_NAMEs: CAMPBELL, ADRIENNE ;NAYAK, KRISHNA S (contact)

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: 3-Dimensional;3D ultrasound;Adult;Air;Anatomy;Arrhythmia;Basic Science;Breathing;Cardiac;Cardiac ablation;Cardiac Catheterization Procedures;Cardiac Output;Cardiovascular system;Caring;Catheterization;Catheters;Clinical;clinical center;clinical translation;cohort;Collaborations;Data;data acquisition;deep learning;Deposition;Detection;Development;Devices;Diagnostic Imaging;Disease;Disease Progression;Early Diagnosis;Engineering;Evaluation;Extramural Activities;flexibility;Goals;Heart;heart function;heart imaging;Heating;Image;image reconstruction;imaging approach;imaging modality;Imaging technology;improved;innovation;instrument;Intervention;Ionizing radiation;lung imaging;magnetic field;Magnetic Resonance Imaging;Manuals;Methods;millisecond;Modality;Monitor;Morphologic artifacts;Motion;Movement;Myocardial;National Heart, Lung, and Blood Institute;next generation;novel;Obstructive Sleep Apnea;Organ;Outcome;Patients;Pattern;Performance;Physiologic pulse;Procedures;programs;prospective test;radio frequency;real-time images;reconstruction;Relapsing polychondritis;Relaxation;Research;Resolution;respiratory imaging;Sampling;Scanning;Scientist;simulation;Sleep Apnea Syndromes;Slice;soft tissue;spatiotemporal;Surface;synergism;System;Techniques;Technology;temporal measurement;Testing;Time;Tissues;Trachea;tracheomalacia;Training;Translating;Ultrasonography;ultrasound;United States National Institutes of Health;Variant;Visualization;volunteer;Work;X-Ray Computed Tomography

PROJECT_TITLE: Volumetric Real-Time MRI at 0.55 Tesla


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: DAVIS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The proposed research is relevant to public health because it will test a novel multi-pronged therapeutic paradigm for HIV/AIDS, and will further elucidate its underlying mechanism of action. Findings will provide solid grounds upon which to develop innovative HIV curative strategies that target CD8 T cell exhaustion and viral sequestration. Thus the proposed research is relevant to ORIP’s mission that pertains to supporting veterinarian scientists pursuing translational research projects using non-human primate models.

PI_NAMEs: KOL, AMIR  (contact)

PROGRAM_OFFICER_NAME: MIROCHNITCHENKO, OLEG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adopted;Allogenic;Animals;antiretroviral therapy;Autopsy;B-Lymphocytes;Biological Assay;Blood;BLR1 gene;CD8-Positive T-Lymphocytes;cell killing;Chronic;Clinical Trials;Color;Complex;Confocal Microscopy;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Epigenetic Process;Exclusion;exhaust;exhaustion;Flow Cytometry;Foundations;Functional disorder;Genetic Transcription;global health;Goals;Granzyme;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV/AIDS;Immune;immune cell infiltrate;Immune response;Immunity;Immunohistochemistry;immunoregulation;improved;In Situ;In Vitro;Infiltration;Infusion procedures;innovation;Interruption;Intestinal Mucosa;Intravenous infusion procedures;Knowledge;Location;lymph nodes;Lymphoid Follicle;Macaca;Macaca mulatta;Malignant Neoplasms;Mesenchymal;Microanatomy;Mission;Modeling;Molecular;molecular marker;nonhuman primate;novel;novel therapeutics;Pathogenesis;Patients;Peripheral;peripheral blood;Phenotype;Population;pre-clinical;Process;Production;programs;Property;Public Health;receptor;Rejuvenation;Research;Research Project Grants;response;Role;Safety;Sampling;Scientist;single-cell RNA sequencing;Site;SIV;Solid;Sorting;Stains;stem;Stromal Cells;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;therapeutic candidate;therapeutic target;Tissues;trafficking;Translational Research;Veterinarians;Viral;Viral Load result;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Latency;Virus Replication

PROJECT_TITLE: Mesenchymal stem/stromal cells to enhance cytotoxic T cell immunity during HIV infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Lung;Lung Cancer;Rare Diseases;Sleep Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: 8. Project Narrative Environmental disruption of circadian rhythms caused by altered timing of light exposure as occurs in shift work increases the risk of several types of cancer, including lung cancer. We found that an altered lighting schedule that mimics the circadian disruption experienced by shift workers enhances tumor formation in a mouse model of KRAS-driven lung adenocarcinoma. This project tests the hypothesis that increased tumor formation in response to chronic circadian disruption is caused by perturbation of normal daily cycles in signaling through the transcription factor heat shock factor 1 (HSF1), which leads to chronic activation of a molecular proteotoxic stress response pathway.

PI_NAMEs: LAMIA, KATJA A (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Address;Affect;Animals;anti-cancer research;Behavior;Biological;biological adaptation to stress;Breast Cancer Model;cancer risk;cancer type;Carcinogens;Cell Physiology;cell type;Cells;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Cytometry;Data;design;Detection;Development;digital;disorder risk;Epidemiology;Exhibits;experience;experimental study;Exposure to;Future;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Growth;Health;heat shock transcription factor;Heat Stress;heat-shock factor 1;Helicobacter pylori;Hour;in vivo;Incidence;insight;International Agencies;Investigation;Jet Lag Syndrome;K-ras mouse model;Kinetics;Knowledge;KRAS oncogenesis;KRAS2 gene;KRASG12D;Light;Lighting;Link;Location;Lung;Lung Adenocarcinoma;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;Metabolic Diseases;Molecular;mouse model;Mus;mutant;Nervous System Disorder;Nuclear;Oncogenic;Outcome;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Periodicity;Peripheral;Persons;Physiological;Physiology;Play;Probability;proteostasis;proteotoxicity;Public Health;RAS driven cancer;Research;Resolution;response;Risk;Role;Schedule;shift work;Signal Transduction;Skin Cancer;Source;Stimulus;Stress;System;temporal measurement;Testing;Time;transcription factor;transcriptome sequencing;transcriptomics;Travel;tumor;tumor barcoding and sequencing;Tumor Burden;tumor microenvironment;tumorigenesis;Vulnerable Populations;Work

PROJECT_TITLE: Establishing a mechanistic basis for enhanced tumorigenesis under chronic circadian disruption

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(02)M]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Mental Illness;Pediatric

ORG_CITY: TEMPE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: Project Narrative This study will use newly developed person-centered and multidimensional approaches to identify which parentally bereaved children experience problems in grief, mental health or development of competencies over six years and could benefit from an effective program. The study also tests the effects of the Family Bereavement Program (FBP) to reduce those problems in childhood and how reducing problems in childhood leads to reduced mental health problems in adulthood. The findings will have implications for who should receive services and how to optimize the FBP for dissemination to the public.

PI_NAMEs: SANDLER, IRWIN N. (contact);TEIN, JENN-YUN

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Adolescence;Adult;Age;Behavior;Bereavement;Cessation of life;Child;Child Mental Health;Childhood;Chronic;Competence;competence factor;COVID-19;Data Analyses;Development;dimensional analysis;Dimensions;Disease;effective intervention;Evaluation;evidence base;experience;Family;Family Study;Feeling suicidal;Generalized Anxiety Disorder;Goals;Grief reaction;health service use;Impairment;improved;Individual;Individual Differences;Intervention;Longitudinal Studies;Major Depressive Disorder;Mediating;Mediation;Mediator;Mental Depression;mental development;Mental disorders;Mental Health;Mental Health Services;Methods;National Institute of Mental Health;Outcome;pandemic disease;Paper;Participant;peer;person centered;Persons;Population;Prevalence;program dissemination;programs;protective factors;Publishing;randomized trial;Reporting;Research;resilience;responders and non-responders;Risk;Risk Factors;Risk Reduction;Sampling;secondary analysis;Services;Strategic Planning;Stressful Event;suicidal;suicidal behavior;Testing;Time;traumatic event;young adult

PROJECT_TITLE: A multidimensional approach to assessing six-year trajectories of outcomes of bereaved children, the effects of the FBP to modify trajectories and mediation of effects 15 years later

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: DK

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative Skeletal muscle satellite cells (MuSCs) are tissue stem cells responsible for muscle repair in response to injury and degenerative diseases. This project aims to investigate the novel role played by lipid droplets and lipid metabolism in satellite cell biology. Knowledge from the proposed work will lead to better understanding of the cellular and molecular regulation of MuSC function in the context of muscle regeneration under pathological conditions.

PI_NAMEs: KUANG, SHIHUAN  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acetylation;Adipocytes;Adult;Affect;Aging;Biochemical;Biogenesis;Catabolism;Cell Cycle;Cell Differentiation process;Cell Fate Control;Cell Nucleus;Cell Physiology;Cell Proliferation;Cell Respiration;Cells;Cellular biology;Cellular Metabolic Process;Centrosome;Citric Acid Cycle;Cues;Data;Degenerative Disorder;Development;DNA;Energy Supply;Exhibits;fatty acid oxidation;Fatty Acids;glucose metabolism;Growth;Homeostasis;improved;In Vitro;in vivo;Injury;injury and repair;insight;Knowledge;Label;Laboratories;Link;lipid biosynthesis;lipid mediator;lipid metabolism;lipidomics;Lipids;Lipolysis;Maintenance;Maps;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Molecular;Molecular Profiling;Muscle;Muscle function;muscle regeneration;muscle repair;Muscle satellite cell;Myoblasts;Natural regeneration;nerve stem cell;novel;Nutrient;Organelles;Pathogenesis;Pathologic;Pattern;Phosphorylation;Play;postnatal;Production;Proliferating;Protein Acetylation;Proteins;regeneration function;Regenerative capacity;Regulation;Reporting;response to injury;Role;segregation;self renewing cell;Self-Injurious Behavior;self-renewal;Signal Transduction;Sister;Skeletal Muscle;Skeletal Muscle Satellite Cells;stem cell biology;stem cell fate;stem cell function;stem cells;STK11 gene;System;Testing;tissue stem cells;Translating;Transplantation;tumor metabolism;Work

PROJECT_TITLE: Metabolic regulation of muscle satellite cell homeostasis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Periodontitis is chronic gum inflammation leading to systemic inflammation and neuroinflammation and may subsequently promote the pathogenesis of Alzheimer’s disease. The proposed study will identify a novel mechanism by which periodontitis increases succinate in cerebrospinal fluid and activates succinate receptor in microglia to induce neuroinflammation and neurodegeneration. The study will provide a potential therapeutic strategy by targeting succinate receptor.

PI_NAMEs: LI, XIN  (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acute;Age;Alveolar Bone Loss;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease therapy;amyloid pathology;antagonist;arm;assault;Autopsy;Behavior;behavior test;Blood specimen;Brain;Brain Diseases;brain tissue;CASP1 gene;Cell Nucleus;Cells;Cerebellum;Cerebrospinal Fluid;Chronic;Citric Acid Cycle;Cognition;Cognitive;cohort;cytokine;Data;Dementia;Development;Disease;dysbiosis;Etiology;Exhibits;extracellular;Female;Formulation;Funding Opportunities;Fusobacterium nucleatum;Gel;Gender;Gene Expression;Genotype;Gingiva;glial activation;Growth;high risk;Hippocampus;Histology;Homeostasis;Immunoblot Analysis;Impaired cognition;In Situ Hybridization;In Vitro;in vivo;Inflammasome;Inflammation;Inflammatory;Injections;Interleukin-1 beta;Knock-out;Knockout Mice;Ligands;Ligature;Location;male;marenostrin;Measures;Mediating;Messenger RNA;metagenomic sequencing;Microglia;Modeling;Monitor;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;new therapeutic target;novel;novel therapeutics;Nuclear;object recognition;Oral;Oral health;oral microbial community;oral microbiome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;performance tests;Periodontitis;periodontopathogen;Proteins;Randomized;receptor;Receptor Activation;receptor expression;Receptor Signaling;Research;response;Rodent;Role;sample collection;Serum;Signal Transduction;Succinates;systemic inflammatory response;Testing;Therapeutic;Tissue Banks;Tissue Sample;touchscreen;transcriptome sequencing;virulence gene;Virulent;Wild Type Mouse

PROJECT_TITLE: Succinate signaling in periodontitis induced neuroinflammation and dementia


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Regenerative Medicine;Transplantation;Wound Healing and Care

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Corneal blindness affects millions worldwide, with less than 2% of patients having access to donor corneal tissue required for a sight-restoring transplant. A way to transparently restore scarred stromal tissue and support epithelial re-growth without the need for sutures or graft tissue would be of great benefit to patients suffering from the blinding consequences of corneal injury and disease. To this end, this research seeks to develop a novel therapy that suturelessly removes and replaces corneal scars with mesenchymal stromal cells encapsulated within an in situ-forming, transparent gel designed to regenerate healthy corneal tissue and potentially stave off the need for traditional transplant surgery.

PI_NAMEs: MYUNG, DAVID  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Actins;Address;Affect;Alkynes;analog;Anterior;Autologous;Azides;Behavior;beneficiary;Biological Assay;biological systems;Biomedical Engineering;Blindness;Burr hole procedure;Cadaver;catalyst;Cell Survival;Cells;Central Scar;Chemistry;Cicatrix;Clinical;clinical translation;Coculture Techniques;Collagen;Copper;Cornea;Corneal Diseases;corneal epithelial wound healing;corneal epithelium;Corneal Injury;corneal scar;corneal surgery;cross reactivity;crosslink;curative treatments;Custom;cycloaddition;Data;Defect;design;Dimensions;Disease;Encapsulated;Engineering;Enzyme-Linked Immunosorbent Assay;Epithelial Cells;Epithelium;Esters;Evaluation;Excision;Exhibits;Eye;FDA approved;Fluorescamine;Fluorescein;Fostering;Gel;graft failure;Growth;Growth Factor;Harvest;healing;HGF gene;Hydrogels;Immunohistochemistry;improved;In Situ;In Vitro;in vivo;Inflammation;Keratoplasty;Light;Liquid substance;Mechanics;Mediating;mesenchymal stromal cell;Modality;Modeling;Morphology;Natural regeneration;novel therapeutics;Operative Surgical Procedures;Optics;Organ Culture Techniques;Oryctolagus cuniculus;oxidative damage;paracrine;Paracrine Communication;Patients;Phenotype;phenotypic biomarker;Photochemistry;PicoGreen;preservation;prevent;Procedures;Proliferating;Property;Proteins;re-epithelialization;regenerative;Regenerative capacity;regenerative growth;repaired;Research;Rheology;Riboflavin;severe injury;Shapes;Side;sight restoration;Site;Source;Spectrophotometry;Stains;Stromal Cells;Succinimides;Surface;Surgical sutures;Suspensions;Techniques;Technology;Testing;Therapeutic;Therapeutic Effect;Thick;Time;Tissue Donors;Tissue Grafts;Tissues;Transplantation;Transplantation Surgery;Viscosity;Vision;Visual impairment;Visual Pathways;Western Blotting;Work;wound;wound healing

PROJECT_TITLE: Corneal Scar Repair through SPAACKL:  Sutureless, Pro-regenerative Anterior Additive Collagen gel KeratopLasty

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stroke

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Germinal matrix intraventricular hemorrhage (IVH) occurs in 15-20% of babies born before 32 weeks of pregnancy. Lifelong consequences may include post-hemorrhagic hydrocephalus (PHH), developmental delay, and cerebral palsy. We propose to use cutting-edge optical, genetic, molecular, and clinically informed approaches in our mouse model of neonatal IVH to test if two distinct and complementary endogenous responses to intraventricular blood can be harnessed to mitigate IVH sequelae: (1) ChP-NKCC1 gene therapy to remove excess CSF, and (2) macrophage clearance of ventricular blood. Our findings will give insight into the sequence and causality of events following IVH, unveil new therapeutic targets, and test the first potential gene therapy for PHH.

PI_NAMEs: LEHTINEN, MARIA  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: absorption;Adult;Apical;Biology;Blood;blood product;Brain;Brain hemorrhage;Brain Pathology;brain tissue;Calcium;Cell secretion;Cells;Cerebral Palsy;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid clearance;Childhood;chloride-cotransporter potassium;Choroid Plexus Epithelium;Clinical;clinical development;clinical diagnostics;Clinical Treatment;conditional knockout;Data;Demyelinations;Development;Developmental Delay Disorders;Diagnostic Procedure;Drainage procedure;Embryo;Epithelial Cells;Equilibrium;Etiology;Event;Excision;experience;experimental study;extracellular;Extravasation;Fluids and Secretions;FOS gene;gene therapy;Genetic;Goals;Hemorrhage;Home;Homeostasis;Hydrocephalus;Image;Immediate-Early Genes;Immune;improved outcome;Infant;Inflammatory;Infusion procedures;insight;Intraventricular;intraventricular hemorrhage;Ions;life span;Liquid substance;long-term sequelae;Macrophage;Magnetic Resonance Imaging;Membrane Proteins;Modeling;Molecular;Morbidity - disease rate;Motion;mouse model;Mus;Myelin;Neonatal;Neurologic Deficit;new therapeutic target;novel;Operative Surgical Procedures;Optics;Outcome;overexpression;Pathogenicity;Perinatal;Phagocytosis;Phosphorylation;Physiological;postnatal;Pregnancy;Premature Infant;Process;Production;Proteins;Reaction;recruit;Repeat Surgery;Research;Resolution;response;Role;Route;Serial Magnetic Resonance Imaging;Severities;Signal Transduction;Site;Structure of choroid plexus;Supplementation;Surface;System;Testing;Therapeutic;therapy development;Transgenic Mice;Traumatic Brain Injury;two-photon;Ventricular;Viral;Water;Water Movements

PROJECT_TITLE: Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  The goals of this project are to obtain preclinical data on the placental transfer of amenamevir and pritelivir and to assess the reproductive hazard of pritelivir in an animal model to determine the potential use of these novel antiherpesviral drugs for treatment of genital herpes in pregnancy.

PI_NAMEs: BRYANT, VALENTINA FOKINA (contact)

PROGRAM_OFFICER_NAME: SAMEDY BATES, LESLY

PROJECT_TERMS: Abdominal Cavity;Accreditation;Acetazolamide;Acyclovir;Adult;alternative treatment;Ammonium;animal care;animal facility;Animal Model;animal resource;Animal Welfare;Animals;Asphyxia;Biological Sciences;Bladder;Canis familiaris;Carbon Dioxide;carbonate dehydratase;Certification;Chronic;Chronic Toxicity Tests;Classification;Cleft Palate;Clinical;clinical development;Clinical Drug Development;Clinical Trials;Data;Data Set;Dermal;Development;developmental toxicity;DNA Primase;Dose;drug distribution;Dry Ice;Embryo;Enzymes;Epithelium;experience;Experimental Models;exposed human population;Exposure to;Female;fetal;Fetal safety;Fetus;Fixatives;Freezing;genital herpes;Goals;Gravid;hazard;Healthcare;helicase;Hematology;Hematoxylin and Eosin Staining Method;Herpes Simplex Infections;Herpes zoster disease;Human;Hyperplasia;implantation;In Vitro;inhibitor;insight;Investigation;Japan;Laboratories;Laboratory Animals;Letters;light microscopy;Liver;Membrane Transport Proteins;men;Microdissection;Microscopic;Monkeys;Morbidity - disease rate;Morphology;mortality;Mothers;Mus;natural hypothermia;neonate;Newborn Infant;novel;novel therapeutics;nucleoside analog;Oral;Oral Administration;Organogenesis;Oryctolagus cuniculus;Paraffin;Partner in relationship;Pathologic;Pathologist;Perinatal transmission;Pharmaceutical Preparations;pharmacophore;Pharmacotherapy;Phase I Clinical Trials;Phase II Clinical Trials;phase II trial;Phase III Clinical Trials;phase III trial;Placebos;Placenta;placental transfer;pre-clinical;Pregnancy;Pregnant Women;preservation;prevent;Rattus;Reporting;reproductive;Research Design;Resistance;response;restraint;Risk;Risk Reduction;Rodent;Role;Safety;Schedule;Sectioning technique;side effect;Simplexvirus;Site;Stains;standard care;Sulfites;Sulfonamides;Summary Reports;Supervision;Techniques;technology validation;Terminology;Thoracic cavity structure;Time;Tissues;Toxic effect;Toxicology;Training;transmission process;Uterus;Veterinarians;viral transmission;Virus Shedding;Visceral;Visualization;Woman;Work

PROJECT_TITLE: Human placental biodisposition of novel antiherpesviral drugs, amenamevir and pritelivir, using ex vivo and in vitro experimental models

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative Rapid progress in experimental neuroscience techniques and machine learning-based models for the brain presents a common challenge in understanding high-dimensional (many neurons) neural representations in an interpretable and quantifiable way. This proposal represents a path to a multi-level framework for connecting neural representational geometry to multiple scales (neurons to regions) and levels of computational abstraction, such as (i) the effect of single neuron tuning properties on neural representations, (ii) the role of region-to-region transformations and task-learning, and (iii) new algorithms for training neural network models of the brain via geometry and machine learning. The synergy between two modern approaches – task-efficient representational geometry and machine learning – will lead to new fundamental principles and methods in computational neuroscience and enable multi-level, multi-scale theory of neural representations and discover common principles of neural computation across different brain regions and multiple modalities.

PI_NAMEs: CHUNG, SUEYEON  (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: Acceleration;algorithm training;Algorithmic Analysis;Algorithmic Software;Algorithms;Animals;Area;artificial neural network;Behavior;Behavioral;Biological;Brain;Brain region;Code;Cognition;cognitive task;Communities;Complex;computational neuroscience;Computer Analysis;Data;Data Analyses;design;Development;geometric structure;Geometry;Goals;Heterogeneity;high dimensionality;Human;Individual;insight;Learning;Machine Learning;machine learning model;Mathematics;Measures;Methods;Modality;Modeling;Modernization;network architecture;neural;neural circuit;Neural Network Simulation;neuromechanism;Neurons;Neurosciences;novel;object recognition;open source;Outcomes Research;Pattern;Perception;Population;Property;Research;response;Role;Sensory;Shapes;Signal Transduction;spatiotemporal;Stimulus;Structure;Synapses;synergism;System;Task Performances;Techniques;Testing;theories;tool;Training;Work

PROJECT_TITLE: A multi-level framework for characterizing task-efficient coding geometry of neural population activities

STUDY_SECTION_NAME: Special Emphasis Panel[ZEB1 OSR-F (A1)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Hypertension;Infectious Diseases;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Pregnancy;Women's Health Research

ORG_CITY: JACKSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Preeclamptic women, women with newly developed hypertension during pregnancy, have elevated autoantibodies and inflammatory markers and cells programmed to kill virus infected cells or tumor cells. However, the exact pathway linking the pregnancy and the activation of these specialized cells, autoantibodies or inflammatory factors with the increase in blood pressure and intrauterine growth restriction associated with preeclampsia has yet to be clearly defined. This proposal focuses on determining specific cellular interactions that lead to the production of autoantibodies and other factors that cause increased blood pressure and decreased fetal growth during pregnancy and hypertension in the offspring.

PI_NAMEs: LAMARCA, BABBETTE  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Adult Children;Affect;Attenuated;Autoantibodies;blood pressure elevation;Cardiovascular Diseases;Cell Culture Techniques;Cell secretion;Cells;Cerebrovascular Disorders;Cerebrum;Cessation of life;Chronic;cognitive function;COVID-19;COVID-19 pandemic;COVID-19 patient;Data;Development;Disease;endothelial dysfunction;Engineering;Exhibits;Female;Fetal Growth;Fetal Growth Retardation;Functional disorder;Genetic Complementation Test;Headache;hemodynamics;Hospitals;Hypertension;hypertensive;Immune;immune activation;Immunologics;Impaired cognition;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;inflammatory marker;Ischemia;Kidney;Link;Long COVID;male;maternal hypertension;maternal morbidity;Medical center;Memory Loss;Mississippi;Modeling;Molecular;Natural Killer Cells;neoplastic cell;NK Cell Activation;normotensive;novel;offspring;Pathogenesis;Pathway interactions;Patients;Peptides;Perfusion;Perinatal;perinatal morbidity;pharmacologic;Phenotype;Physiological;Placenta;Postpartum Hypertension;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnant;Pregnant Women;pressure;Production;Rattus;Receptor, Angiotensin, Type 1;Recording of previous events;Renal function;Research;response;Role;SARS-CoV-2 infection;SARS-CoV-2 infection history;sex;Sex Differences;Techniques;Testing;Universities;Uterus;vasoconstriction;Virus;Woman

PROJECT_TITLE: Sex differences in hypertension, cognitive function and renal hemodynamics; a role for B cells and autoantibodies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-P (52)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Carpal Tunnel Syndrome (CTS) is an idiopathic age-related disease that impacts 10 million people per year in the US alone. This age-related disease presents at middle-age and results in significant quality of life and work force issues for patients. The experiments outlined in this proposal are designed to validate the role of cellular senescence in CTS and determine the efficacy of targeting cellular senescence in CTS.

PI_NAMEs: GINGERY, ANNE  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Affect;age related;age related chronic disease;age-related disease;Aging;aging process;aging related disease;American;Animal Model;Apoptosis;Appearance;Attenuated;Automobile Driving;beta-Galactosidase;Biology;Biopsy;Carpal Tunnel Syndrome;CD47 gene;CDKN2A gene;Cell Aging;Cell model;Cells;cellular targeting;comorbidity;Connective Tissue;Connective Tissue Cells;cost;cost estimate;Dasatinib;Data;design;Diabetes Mellitus;Disease;disease mechanisms study;disease phenotype;Disease Progression;effective therapy;efficacy evaluation;Etiology;Exhibits;experimental study;Failure;Fibroblasts;Fibrosis;Geroscience;Hormonal Change;Human;Immune Evasion;In Vitro;in vivo;innovation;Interferon Type II;Intervention;lost work time;median nerve;Metabolic;middle age;Modeling;Molecular;National Institute of Neurological Disorders and Stroke;new therapeutic target;novel;novel therapeutic intervention;Obesity;Operative Surgical Procedures;Oryctolagus cuniculus;Pathologic;pathological aging;Pathology;Pathway interactions;Patients;PDGFA gene;Persons;pharmacologic;Plasminogen Activator Inhibitor 1;Play;Prevalence;Prevention;programmed cell death ligand 1;Quality of life;Quercetin;Resistance;Resolution;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;senolytics;Severities;Testing;Therapeutic;therapeutic target;Time;tissue culture;Tissues;TP53 gene;Transforming Growth Factor beta;Translating;transplant model;Transplantation;Work;wound healing

PROJECT_TITLE: The Role of Cellular Senescence in Carpal Tunnel Syndrome

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Late recurrence stemming from acquired therapy resistance is a persistent clinical problem for patients with estrogen receptor (ER)+ breast cancer. We propose that steroid receptor (SR) co-activators, PELP1 and SRC- 3, cooperate as key inputs to oncogenic signaling pathways that mediate therapy resistance mechanisms, such as the survival of cancer stem cells (CSC). Identifying and targeting reversible events that drive metastatic ER+ tumor cells is an unmet need that has the potential to extend patient lives and improve well-being.

PI_NAMEs: TRUONG, THU HA (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Accounting;Adopted;advanced disease;Aftercare;Area;Automobile Driving;Binding;Biological;Biology;Breast;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;breast cancer progression;cancer cell;cancer diagnosis;cancer stem cell;cancer survival;candidate identification;candidate validation;career;Cell Compartmentation;Cell model;Cell Nucleus;Cell Survival;Chemoresistance;chemotherapy;Clinical;Complex;Cytometry;Cytoplasm;Data;Development;Disease;Disease Progression;Distant Metastasis;Endocrine;Enzymes;Estrogen receptor positive;Estrogen Receptors;Event;Family member;Foundations;Genes;genetic signature;Genetic Transcription;Goals;Growth;Growth Factor;Health;hormone therapy;Human Biology;Impairment;improved;in vitro Model;in vivo;K22 Award;knock-down;Link;Malignant Breast Neoplasm;mammary;Mammary Neoplasms;Mediating;Mediator;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Metastatic breast cancer;Minority Groups;Modeling;Molecular;NCOA3 gene;Neoplasm Metastasis;neoplastic cell;novel;Nuclear;Oncogenic;Organoids;Paclitaxel;Pathway interactions;Patient-Focused Outcomes;Patients;Personal Satisfaction;Phenocopy;Phenotype;Phosphoric Monoester Hydrolases;Phosphotransferases;Population;predictive signature;Progesterone Receptors;Proliferating;Publishing;Recurrence;Relapse;Reporting;Research;Resistance;Resistance development;resistance mechanism;Role;Scaffolding Protein;self-renewal;Signal Pathway;Signal Transduction;Site;Solid;standard care;stem;stem cell biology;stem cell expansion;stem cell population;stem cell survival;Steroid Receptors;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;transcriptome sequencing;translational cancer research;tumor;tumor metabolism;tumor progression;Woman;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Targeting Oncogenic PELP1/SRC-3 Signaling Complexes in ER+ Breast Cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy;Infectious Diseases

PHR: Contact PD/PI: Tinoco, Roberto PROJECT NARRATIVE The proposed research is relevant to public health because discovering how PSGL-1 signaling mediates immune inhibition is anticipated to increase our understanding of pathways that suppress the immune system. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to development of fundamental knowledge to help reduce the burdens of patients afflicted with chronic viral infection and cancer. Project Narrative Page 7

PI_NAMEs: TINOCO, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: adhesion receptor;Anti-viral Response;Antigens;Autoimmune Diseases;Biology;Blocking Antibodies;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Adhesion Molecules;cell motility;Cell Physiology;cell type;Cells;Chronic;Chronic Disease;Colitis;Combined Modality Therapy;CTLA4 gene;Development;Disease;Down-Regulation;Drug Targeting;Economic Burden;effector T cell;exhaust;exhaustion;Experimental Autoimmune Encephalomyelitis;Functional disorder;Goals;Grant;Hepatitis C virus;HIV;Human;Immune;immune checkpoint blockade;Immune response;Immune system;Immune Targeting;Immunity;immunoregulation;Immunotherapy;improved;in vivo;Induction of Apoptosis;Infection;innovation;Knockout Mice;Knowledge;Link;Lymphocytic choriomeningitis virus;Mediating;Melanoma;Mission;Modeling;Molecular;Monkeys;Morbidity - disease rate;mortality;Mus;Myeloid Cells;new therapeutic target;novel drug class;novel therapeutic intervention;novel therapeutics;Outcome;P-selectin ligand protein;pathogen;Pathway interactions;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;prevent;Primates;programmed cell death ligand 1;programmed cell death protein 1;Proteins;Proteomics;Public Health;Publishing;receptor;receptor expression;Receptor Signaling;Recombinants;Regulation;Regulatory T-Lymphocyte;Research;safe patient;Signal Pathway;Signal Transduction;standard care;success;T cell differentiation;T cell response;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;Toxic effect;translational impact;tumor;Tumor Escape;unilamellar vesicle;United States National Institutes of Health;Viral;Viral Cancer;Virus Diseases;virus related cancer

PROJECT_TITLE: PSGL-1 mechanisms of T cell exhaustion

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cannabidiol Research;Cannabinoid Research;Digestive Diseases;Emerging Infectious Diseases;Endocannabinoid System Research;Foodborne Illness;Genetics;Infectious Diseases;Microbiome;Neurosciences;Therapeutic Cannabinoid Research

ORG_CITY: MADISON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PI_NAMEs: SPERANDIO, VANESSA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 2 year old;2-arachidonylglycerol;Adrenergic Agents;Animals;Antibiotics;Applications Grants;Attenuated;Beta-glucuronidase;Biochemical;Cannabidiol;Cannabinoids;Carbon;Child;Citrobacter rodentium;Colitis;Disease;Down-Regulation;Endocannabinoids;endogenous cannabinoid system;Enterocytes;Enzymes;Epinephrine;Epithelial Cells;Equilibrium;Escherichia coli;Escherichia coli EHEC;experimental study;FDA approved;Gene Expression;Gene Expression Regulation;Genes;Genetic;Glucuronates;Goals;Grant;Hormones;In Vitro;Infection;Instruction;Intestines;Isomerase;Knock-out;Knowledge;Large Intestine;Lesion;Liposomes;Maps;Mediating;Membrane;microbiota;mouse model;Mus;mutant;Neurotransmitters;Norepinephrine;novel therapeutic intervention;Oxidopamine;pathogen;Pathogenesis;Pathogenicity Island;Pathway interactions;pharmacologic;Plants;prevent;Principal Investigator;Process;Production;programs;Progress Reports;protein expression;protein-histidine kinase;Quantitative Reverse Transcriptase PCR;quorum sensing;receptor;reconstitution;Regulation;Regulon;Research;response;Role;Signal Transduction;Source;Stress;Sugar Acids;System;transcriptomics;Translating;United States National Institutes of Health;uronate;Virulence;virulence gene;Western Blotting

PROJECT_TITLE: Quorum Sensing Regulation of EHEC Virulence Genes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Epilepsy;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Recurrent seizures are the most common manifestation of an acute brain insult in neonates and children and are often resistant to antiepileptic drugs that target inhibitory chloride permeable GABAA receptors. It is well established that hypoxia-ischemia (HI) induces neuronal chloride elevation resulting in cytotoxic edema and recurrent seizures. Emergent prevention of neuronal chloride influx might reduce cell swelling, restore GABAergic inhibition, improve treatment and prevent seizures.

PI_NAMEs: DZHALA, VOLODYMYR  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;Admission activity;anti-epileptic agents;Anticonvulsants;Astrocytes;Biological Assay;Blood - brain barrier anatomy;Brain;Brain Hypoxia-Ischemia;Carotid Arteries;Cations;cell injury;cell type;Cell Volumes;Cells;Cerebral Palsy;Child;Chlorides;Chronic;Circulation;clomeleon;Cytoplasm;cytotoxic;Data;deprivation;disability;Drug Targeting;Early treatment;Edema;Epilepsy;Epileptogenesis;experimental study;extracellular;fluorescence lifetime imaging;fluorophore;gamma-Aminobutyric Acid;Glucose;Goals;high risk;Hippocampus;Hour;Human;hypoxic ischemic injury;Image;improved;In Vitro;in vivo;Incidence;Induced Neurons;inhibitor;Injury;Interneurons;Ischemia;Ligation;LoxP-flanked allele;Measurement;Measures;Membrane;Modeling;Monitor;multiphoton microscopy;Mus;Neonatal;neonatal human;neonatal hypoxic-ischemic brain injury;neonatal injury;neonatal seizure;neonate;Neuronal Injury;Neurons;Newborn Infant;Outcome;Oxygen;Pathway interactions;Perfusion;Perinatal Hypoxia;Permeability;postsynaptic;Potassium;Potassium Chloride;Preparation;prevent;Prevention;Process;Pyramidal Cells;Randomized;ratiometric;receptor;receptor-mediated signaling;Recovery;Recurrence;Regulation;Reperfusion Therapy;Resistance;Role;Salts;Seizures;Severities;Signal Transduction;Sodium Chloride;sodium-potassium-chloride cotransporter 1 protein;spreading depression;Swelling;symporter;synaptic inhibition;Testing;Therapeutic;therapeutically effective;Tissues;Transgenic Organisms;treatment strategy;two photon microscopy;two-photon;uptake;Water

PROJECT_TITLE: Timing of Neuronal Chloride Uptake for Control of Neonatal Seizure


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Epithelial polarization – an essential biological process serving many physiological roles including tissue morphogenesis and wound healing – relies on the separation of the cell plasma membrane into distinct apical and basolateral domains with unique lipid and membrane-protein constituents. Despite the critical nature of polarization, the fundamental determinants of the composition, structure, and function of apical and basolateral membrane domains remain unknown. I will examine the lipid components of the membrane and the consequent biophysical membrane properties, investigate the structural determinants of polarized protein sorting, and explore the role of apical plasma membrane elements on determining membrane structure, namely the formation of epithelial tubules such as cilia or microvilli.

PI_NAMEs: SHURER, CAROLYN RENEE (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Achievement;Affect;Affinity;Apical;apical membrane;Automobile Driving;basolateral membrane;Behavior;Binding;Binding Proteins;Biogenesis;Biological Process;Biology;biophysical properties;Biophysics;Cell membrane;Cell Separation;Cells;Cellular Membrane;cellular microvillus;Cholesterol;Cilia;Client;Complement;crosslink;Development;Diffusion;driving force;Elements;Embryonic Development;Engineering;environmental enrichment for laboratory animals;Epithelial Cells;Epithelium;Excretory function;experimental study;extracellular;Extracellular Space;Family;fluidity;Formulation;Galactose Binding Lectin;Generations;Glycocalyx;Glycolipids;Glycoproteins;glycosylation;Goals;Homeostasis;Human body;Imaging Techniques;insight;Integral Membrane Protein;Knowledge;Lateral;Lectin;lipidome;lipidomics;Lipids;Maintenance;Mass Spectrum Analysis;Mediating;Membrane;membrane assembly;membrane biogenesis;Membrane Biology;Membrane Lipids;Membrane Microdomains;Membrane Proteins;Methods;Molecular;Morphogenesis;Morphology;Mucins;Nature;Organelles;Phase;Phenotype;Physiological;polarized cell;Polysaccharides;Post-Translational Protein Processing;prevent;Process;Property;Protein Engineering;Protein Glycosylation;Protein Sorting Signals;Protein Sortings;Proteins;Regulation;Role;saturated fat;self assembly;Shapes;Signal Transduction;Sorting;Sphingolipids;structural determinants;Structure;sugar;Surface;System;Testing;Tissues;trafficking;Transmembrane Domain;Uncertainty;uptake;Vesicle;Work;wound healing

PROJECT_TITLE: Composition, sorting, and morphology of the apical plasma membrane in epithelial cells.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE These studies will contribute to our understanding of cellular stress responses regulated by the EGF receptor using a host-virus approach. These are fundamental processes in mammalian cells, and as such these studies will have broad medical implications. We propose that many common human disorders such as cancer and a range of inflammatory diseases employ the same cellular stress pathways as infectious agents. Our studies will therefore lead to identification of common biological pathways and new drug targets for multiple human diseases.

PI_NAMEs: CARLIN, CATHLEEN R (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Accounting;Address;Adenovirus Infections;Adenovirus Vector;Adenoviruses;Adult;airway epithelium;airway immune response;Anti-viral Therapy;Apical;apical membrane;Attenuated;Autophagocytosis;Back;basolateral membrane;beta catenin;Biological;biological adaptation to stress;Biological Process;Calmodulin;Cell Adhesion;Cell membrane;Cell model;Cell Polarity;Cells;Cellular Stress;Chronic lung disease;Clathrin Adaptors;Clinical;Cyclic AMP-Dependent Protein Kinases;cytokine;Cytoskeleton;Data;design;Development;Disease;Docking;Endoplasmic Reticulum;endosome membrane;Endosomes;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Exhibits;Exposure to;ezrin;Failure;Future;GAB1 gene;gene product;gene therapy clinical trial;Genes;Genetic Transcription;Goals;Human;human disease;Immune;Immune response;Immune signaling;Individual;Infectious Agent;Inflammatory;innate immune function;Innate Immune Response;Innate Immune System;insight;Invaded;Knowledge;Lead;Ligands;Link;Lung infections;Malignant Neoplasms;Mammalian Cell;Medical;Membrane;Membrane Proteins;Modeling;Molecular;Molecular Conformation;Multivesicular Body;Natural Immunity;new therapeutic target;novel;novel therapeutics;Oncolytic;pathogen;Pathogenesis;Pathologic;Pathway interactions;Physiological;Play;Process;protein activation;Protein Sortings;Proteins;public health relevance;receptor;receptor expression;receptor function;Receptor Signaling;Recombinants;Recycling;release of sequestered calcium ion into cytoplasm;Research;respiratory;Respiratory Disease;Respiratory System;Respiratory Tract Infections;response;Role;Serotyping;Signal Pathway;Signal Transduction;Sorting;src-Family Kinases;Stimulus;Stress;Surface;Testing;Therapeutic;Therapeutic Intervention;Tissues;TNF gene;trafficking;transcytosis;Transplant Recipients;Virus

PROJECT_TITLE: Role of epithelial cell intracellular trafficking in the innate immune response to adenovirus infection

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Genetics

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PUBLIC HEALTH RELEVANCE/ PROJECT NARRATIVE: Functional protein production necessitates highly stable and processive RNA polymerase II (RNAPII) elongation, with synthesis of the average human messenger RNA (mRNA) requiring RNAPII to transcribe over 30 kilobases of genomic sequence without dissociating from the DNA template. In contrast, promiscuous transcription by RNAPII of enhancers and other regulatory elements is typically terminated within several hundred bases. Here we will study this dichotomy, elucidating the nucleic acid sequences and protein factors that selectively promote productive elongation of mRNAs, and those that drive efficient termination of unwanted RNA species.

PI_NAMEs: ADELMAN, KAREN L (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 5' Splice Site;Address;Affect;Anti-sense RNA;Architecture;Automobile Driving;base;Base Pairing;Base Sequence;Behavior;Binding Proteins;Biochemical;Biogenesis;Bioinformatics;Biological Assay;Cell Line;Cell-Free System;Cells;Chromatin;chromatin modification;Chromatin Remodeling Factor;cis acting element;Cis-Acting Sequence;Code;Complement;Complex;CRISPR/Cas technology;Data;Data Set;Development;Disease;Dissection;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA Insertion Elements;DNA Repair;Double-Stranded RNA;egg;Enhancers;enhancing factor;Environment;Enzymes;Eukaryota;Evolution;Exhibits;Exons;experimental study;Fluorescence;Gene Expression;Generations;Genes;Genetic Transcription;Genomic Instability;genomic locus;Genomics;Goals;Growth;Homeostasis;Human;Immune System Diseases;In Vitro;in vivo;innovation;interest;Introns;Length;Libraries;Malignant Neoplasms;Mammals;Mass Spectrum Analysis;Measures;Mediating;Messenger RNA;Methods;Modeling;Molecular;Monitor;Mouse Embryonic Stem Cells;mutant;Mutate;Mutation;Nature;Nerve Degeneration;novel;Nucleoplasm;Play;Polyadenylation;Polymerase;premature;Prevalence;prevent;Production;Productivity;promoter;Property;protein complex;Proteins;public health relevance;Recombinant Proteins;recruit;Regulation;Regulatory Element;Reporter;Research;response;RNA;RNA analysis;RNA chemical synthesis;RNA Polymerase II;RNA Processing;RNA Splicing;Role;screening;Signal Transduction;small molecule;Suggestion;Surface;System;termination factor;Terminator Regions;Testing;Tissues;Transcript;Transcription Elongation;Transcription Initiation Site;transcription termination;transcriptome sequencing;U1 Small Nuclear Ribonucleoprotein;U1 small nuclear RNA;Untranslated RNA;Variant;Work;Xenopus

PROJECT_TITLE: Identifying the sequences and factors that govern the fate of elongating RNAPII

STUDY_SECTION: MGA

STUDY_SECTION_NAME: Molecular Genetics A Study Section[MGA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_DEPT: PATHOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This study sets out to investigate the role of microglia and the neurotrophin receptor p75NTR on neuronal degeneration in frontotemporal dementia. We combine molecular analyses including single-nucleus RNA sequencing in postmortem brain tissue with a dynamic human stem cell model of frontotemporal dementia using patient-derived induced pluripotent stem cells. Co-culture assays, overexpression and knockdown of p75NTR as well as cell transplantation and single cell analyses will be performed to elucidate the mechanisms underlying this disease.

PI_NAMEs: HARGUS, GUNNAR  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Address;Alzheimer's Disease;Area;Astrocytes;Autopsy;Award;behavioral impairment;Biological Assay;Brain;brain tissue;brain-derived neurotrophic factor precursor;career development;Cell Death;Cell Death Induction;Cell Survival;Cell Transplantation;Cells;Cellular Stress;Central Nervous System;Cessation of life;Coculture Techniques;Cognition;Comparative Study;Control Groups;curative treatments;cytokine;Data;Dementia;Development;Disease;Down-Regulation;early onset;Engraftment;frontal lobe;Frontotemporal Dementia;gene correction;Gene Expression Profile;glial activation;Goals;High Prevalence;Histologic;Human;human stem cells;IL18 gene;imaging study;Immunocompromised Host;improved;In Vitro;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammatory;insight;knock-down;Language;Ligands;Link;Mediating;Mediator;Microglia;Molecular Analysis;Mus;Nerve Degeneration;Nerve Growth Factor Receptors;neural;Neurites;neurodegenerative dementia;Neurodegenerative Disorders;Neuroglia;neuron loss;neuronal survival;Neurons;neurotrophic factor;NGFR Protein;novel;overexpression;Pathogenesis;Pathologic;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Play;Population;Predisposition;programs;Risk;Role;Signal Induction;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;Site;stem cell model;Stress;Substantia nigra structure;Surface;synaptogenesis;tau mutation;Testing;Therapeutic;Tissues;Training;transcriptome;Transplantation

PROJECT_TITLE: Elucidating the Role of Microglia and Neurotrophin Receptor p75 on Neuronal Degeneration in Frontotemporal Dementia

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PPG Title: Overall: New Approaches to Reduce Cardiovascular Risk RELEVANCE TO PUBLIC HEALTH Our Program Project Grant is dedicated to understanding the molecular mechanisms that regulate production, secretion and metabolism of ApoB-containing lipoproteins with the goal of discovering new therapeutic opportunities for the reduction of residual cardiovascular risk.

PI_NAMEs: HORTON, JAY D. (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Acetyl-CoA Carboxylase;Acyltransferase;Angiopoietins;ANGPTL3 gene;Animals;Antibody Formation;Apolipoproteins B;Binding;Binding Proteins;Binding Sites;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cholesterol;Clinical;Co-Immunoprecipitations;Collaborations;Complex;Coronary heart disease;Cytosol;Dedications;design;Development;DNA Resequencing;Eligibility Determination;Endoplasmic Reticulum;Enzymes;epidemiology study;Event;Fatty Acids;Fatty-acid synthase;Foundations;Funding;Genes;Genetic study;Goals;High Density Lipoproteins;Hypertriglyceridemia;Individual;inhibitor;innovation;insight;Knowledge;LDL Cholesterol Lipoproteins;LIPG gene;Lipids;lipoprotein lipase;Lipoproteins;Liver;loss of function mutation;Low Density Lipoprotein Receptor;Mass Spectrum Analysis;member;Membrane;Metabolic;Metabolic Pathway;Metabolism;mimetics;Molecular;Multienzyme Complexes;Mutation;National Heart, Lung, and Blood Institute;novel;novel strategies;novel therapeutics;originality;Palmitic Acids;Paper;Participant;Pathway interactions;Pharmaceutical Preparations;Physiological;Plasma;population based;prevent;Process;Production;Productivity;Program Research Project Grants;Proteins;Public Health;Publishing;Recording of previous events;Research Personnel;Research Project Grants;Residual state;Resolution;Risk;Series;small molecule;Specificity;Sterols;success;Therapeutic Intervention;tissue culture;transcription factor;Triglycerides;Variant;Very low density lipoprotein;Work

PROJECT_TITLE: New Approaches to Reduce Residual Cardiovascular Risk

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(OA)]


NIH_SPENDING_CATS: Cardiovascular

PROJECT_TERMS: Accounting;Animal Experimentation;cardiovascular risk factor;Coffee;Communication;Computer Assisted;Computer software;Contract Services;Data;Data Storage and Retrieval;Ensure;Equipment;Human Resources;implementation facilitation;Individual;Laboratories;Lead;meetings;member;Monitor;Mouse Strains;National Heart, Lung, and Blood Institute;Notification;novel strategies;Participant;Personnel Management;Preparation;Procedures;Program Research Project Grants;Progress Reports;Protocols documentation;Radiation;Reagent;Recommendation;Reporting;Research Personnel;Research Project Grants;Residual state;Resource Sharing;Role;Safety;Schedule;Supervision;Training;Travel;Universities;Vendor

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


PI_NAMEs: DEBOSE-BOYD, RUSSELL ALFRED (contact)

PROJECT_TERMS: Agarose Chromatography;Aliquot;Animals;Antibodies;Antibody Formation;Area;Baculoviruses;cardiovascular risk factor;Cell Line;cell preparation;Cells;Charge;Clone Cells;Complementary DNA;Core Facility;CRISPR/Cas technology;Cultured Cells;Dedications;Dependovirus;Enhancers;experience;experimental study;Fibroblasts;Freezing;G-substrate;gene function;Generations;Genes;genetic manipulation;Goals;Growth;Guidelines;Human;Hybridomas;in vivo;Incubators;Injections;Insecta;interest;lipid metabolism;Liquid substance;Liver;Maintenance;Mammalian Cell;Metabolic Diseases;Methods;Microscope;Molecular Genetics;Monoclonal Antibodies;monoclonal antibody production;Mus;Mutate;Nitrogen;novel strategies;Open Reading Frames;operation;Oryctolagus cuniculus;Patients;permanent cell line;Plasmids;polyclonal antibody;Production;Program Research Project Grants;promoter;protein function;protein purification;Proteins;Quality Control;Reagent;Recombinant adeno-associated virus (rAAV);Recombinant DNA Research;Recombinant Proteins;Recombinants;Refrigeration;Research Personnel;Research Project Grants;Residual state;Roller Bottle;skin biopsy;stable cell line;Staphylococcal protein A-sepharose;Sterility;Suspension Culture;tissue culture;tool;Transfection;United States National Institutes of Health;Work

PROJECT_TITLE: Tissue Culture & Antibody Production Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Dental, Oral, and Craniofacial Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Wound Healing and Care

ORG_CITY: UNIVERSITY PARK

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: RELEVANCE TO PUBLIC HEALTH Craniomaxillofacial (CMF) injuries need to be treated for protection of the brain as well as aesthetic and functional restoration of the calvaria and the skin but there are no satisfactory treatments available to aid in reconstructing large composite tissues to an acceptable level, much less to natural form and function. The proposed work will investigate the intraoperative bioprinting of composite tissue (bone and skin) constructs with localized delivery of differentiation factors such as miRNA mimics and decellularized tissue components to repair CMF defects on a rat model. Successful completion of the proposed work will have a great potential to pioneer the translation of advanced bioprinting technologies from bench to bedside, which will have incredible advantages in operations for CMF repair in surgical settings for humans in the future.

PI_NAMEs: OZBOLAT, IBRAHIM  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Adipocytes;adipose derived stem cell;Adipose tissue;Allografting;analog;Anatomy;Area;Autologous Transplantation;bench to bedside;bioink;Biological Products;Biology;bioprinting;Blood - brain barrier anatomy;bone;bone quality;Bone Regeneration;Bone Tissue;Brain;Calvaria;CD34 gene;Cell Differentiation process;Ceramics;Choristoma;Clinical;Collaborations;Complex;Cosmetics;craniomaxillofacial;cranium;cytokine;Debridement;Defect;Dermal;Dermis;Deterioration;Development;dosage;Esthetics;Excision;Extracellular Matrix;Fracture;functional restoration;Future;Gene Delivery;gene therapy;Growth;Heterogeneity;Histologic;Human;human stem cells;Immune response;immunodeficiency;immunogenicity;implantation;improved;In Situ;In Vitro;in vivo;Infection;injured;Injury;injury and repair;Intervention;Knowledge;lipid biosynthesis;Manuals;Measures;Mechanics;Methods;MicroRNAs;Modeling;Morbidity - disease rate;morphogens;Natural regeneration;novel;Nude Rats;Operating Rooms;operation;Operative Surgical Procedures;osteogenic;Pathogenicity;Pathway interactions;Patients;Plastic Surgical Procedures;Polymers;Preparation;Procedures;Process;Production;progenitor;Proliferating;Property;Public Health;Rattus;re-epithelialization;reconstruction;Regenerative Medicine;repaired;Rodent Model;Role;scaffold;Scanning;Series;Shapes;Site;Skin;skin healing;skin regeneration;Skin repair;Skin Tissue;soft tissue;stem;stem cell differentiation;stem cells;Sterility;Stratification;subcutaneous;Technology;Testing;Tissue constructs;Tissue Engineering;tissue regeneration;Tissues;Transfection;Translations;Vascularization;Work

PROJECT_TITLE: Intraoperative bioprinting of composite tissues with zonal stratification for craniomaxillofacial reconstruction

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Inflammatory bowel disease (IBD) is an increasingly prevalent disease characterized by chronic inflammatory immune responses directed against the gut microbiota (the collection of microbes and viruses that inhabit the intestine), and severely impedes the health of its sufferers. A major unmet clinical need entails development of improved therapeutic regimens that quell ongoing inflammation while sparing protective immunity. We propose to leverage strain-level variation in a model gut bacterium that is associated with imparting distinct immune phenotypes to identify health-promoting anti-inflammatory pathways to treat IBD.

PI_NAMEs: AHERN, PHILIP PATRICK (contact)

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Address;Adult;Affect;Ally;Anti-Inflammatory Agents;Bacteria;Bacterial Genes;Bacteroides thetaiotaomicron;Chronic;Clinical;Colitis;Collection;Colon;Crohn's disease;cytokine;Development;Disease;Disease remission;Environment;fecal transplantation;fitness;Gene Cluster;Genes;Genetic;Genetic Determinism;Genetic Engineering;genetic manipulation;Genomics;Gnotobiotic;gut bacteria;gut inflammation;gut microbes;gut microbiota;Health;health administration;Health Promotion;Homeostasis;host microbiota;Immune;immune function;Immune response;Immune Tolerance;Immunity;immunoregulation;improved;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;Interleukin-10;Intestines;Knowledge;Lipoproteins;Mediating;Microbe;microbial;Microbial Biofilms;microbiota;Modeling;Molecular;Mus;Nature;novel;Pathogenicity;Pathway interactions;Patients;Phenotype;Positioning Attribute;Predisposition;prevent;probiotic therapy;Probiotics;Production;Refractory;Regimen;Regulatory T-Lymphocyte;Resolution;Severities;symbiont;System;Technology;Testing;Therapeutic;TNF gene;trait;Transplantation;treatment strategy;Ulcerative Colitis;Variant;Virus

PROJECT_TITLE: Unraveling strain-level variation in the induction of anti-inflammatory responses in the intestine

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


PI_NAMEs: MCDONALD, JEFF G (contact)

PROJECT_TERMS: Anabolism;Animals;Bile Acids;cardiovascular risk factor;Catabolism;Cholesterol Esters;Chromatography;Complement;Complex;Coupled;Cultured Cells;Data;Deuterium;Eicosanoids;Ensure;Equipment;experience;experimental study;Fatty Acids;Genes;Goals;High Pressure Liquid Chromatography;improved;Individual;insight;instrument;Isotopes;Leadership;lipid metabolism;lipidomics;Lipids;liquid chromatography mass spectrometry;Liquid substance;mass spectrometer;Mass Spectrum Analysis;Mathematics;Measurement;Measures;Metabolic Pathway;Methods;Nitrogen;Noise;novel;novel strategies;Pathway interactions;Phospholipids;Play;Preparation;Program Research Project Grants;programs;Publications;Research;Research Personnel;Research Project Grants;Residual state;Resolution;Robot;Role;Sampling;Services;Signal Transduction;Specificity;Sphingolipids;stable isotope;Stable Isotope Labeling;Steroids;Sterols;Techniques;Time;ultra high resolution

PROJECT_TITLE: Lipid Mass Spectrometry


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

PI_NAMEs: RADHAKRISHNAN, ARUN  (contact)

PROJECT_TERMS: Animal Experiments;Animal Feed;Animal Model;Apolipoproteins B;Applications Grants;Binding;Binding Proteins;Binding Sites;Blood;Carbohydrates;cardiovascular risk factor;Cell Nucleus;Chemicals;Cholesterol;cholesterol-binding protein;Complex;Coronary Arteriosclerosis;Coronary heart disease;Development;Diet;Dissociation;Drug Kinetics;Eligibility Determination;Endoplasmic Reticulum;Fatty Acids;Gene Activation;Genes;Goals;Golgi Apparatus;Hamsters;Heart Diseases;Hepatic;High Fat Diet;improved;in vivo;indexing;inhibitor;Laboratories;Lead;lipid biosynthesis;lipid disorder;Lipids;Lipoproteins;Liver;Medicine;Membrane;Membrane Proteins;Metabolic;mimetics;Modeling;Modification;Molecular;Mus;nanomolar;novel;novel drug class;novel strategies;novel therapeutic intervention;novel therapeutics;Nuclear;Patients;Peptide Hydrolases;Plasma;prevent;Process;Production;Property;protein complex;Proteins;Rapid screening;Regulatory Element;Research Project Grants;Residual state;Risk;Risk Reduction;Science;small molecule;small molecule inhibitor;Specificity;Stabilizing Agents;Sterols;Structure;three dimensional structure;transcription factor;Transcriptional Activation;Triglycerides;Wild Type Mouse

PROJECT_TITLE: Targeting Scap to Lower ApoB-Containing Lipoproteins (ApoBCL) Production


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE More than 60% of metastatic and castration-resistant prostate cancers (CRPC) contain deletion and mutations of PTEN and TP53 genes, which defined a distinct molecular subtype. This proposed project is expected to illuminate the roles of immune checkpoint B7-H3 in prostate cancer progression and the tumor microenvironment remodeling, as well as provide a compelling rationale for molecular biomarker-driven B7-H3 targeted therapies for patients with metastatic CRPC.

PI_NAMEs: ZHAO, DI  (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: advanced prostate cancer;androgen deprivation therapy;androgen independent prostate cancer;Anti-androgen Therapy;Antibody-drug conjugates;antitumor effect;Biological;Biological Process;Biology;biomarker driven;cancer cell;Cancer Patient;cancer recurrence;CD276 gene;Cells;checkpoint therapy;Clinical;clinically relevant;Combination immunotherapy;Complex;CTLA4 blockade;Cytometry;Data;Defect;Development;Disease;Disease Progression;Gene Deletion;Genetically Engineered Mouse;Goals;Human;Immune;immune checkpoint;Impairment;In Vitro;in vivo;Infiltration;inhibitor;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Modeling;Molecular;molecular marker;molecular subtypes;Monoclonal Antibodies;mouse model;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Nature;novel;novel strategies;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phenotype;Pilot Projects;Play;Pre-Clinical Model;predicting response;predictive marker;programmed cell death protein 1;Prostate;prostate cancer model;prostate cancer progression;PTEN gene;RB1 gene;receptor;Research;Resistance;response;Role;Signal Pathway;Signal Transduction;T cell infiltration;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Time;tool;TP53 gene;transcriptomic profiling;transcriptomics;tumor;tumor microenvironment;Tumor-associated macrophages;Variant

PROJECT_TITLE: Novel Approaches Targeting B7-H3 in Castration-resistant Prostate Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Genetics;Hematology;Human Genome;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE As an orally transmitted pathogen, Epstein-Barr virus (EBV) spreads through saliva, infects tonsil B-cells, and establishes latency in the B-cell compartment in over 95% of the global adult human population. While the balance between latency and lytic reactivation underlies the pathogenesis of EBV-associated diseases, including infectious mononucleosis and nasopharyngeal carcinomas and lymphomas, the mechanisms that mediate this switch remain incompletely understood. The overall goal of this study is to elucidate the role of the protein SFPQ in suppressing EBV lytic reactivation so that these findings can be leveraged for development of lytic induction therapeutic approaches.

PI_NAMEs: MURRAY-NERGER, LAURA  (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Address;Adult;Architecture;B-Lymphocytes;Binding;Biology;Biopsy;Burkitt Lymphoma;Carcinoma;Cell Compartmentation;Cells;collaborative environment;craniofacial;CRISPR screen;Detection;Development;Disease;DNA;DNA Binding;DNA-Binding Proteins;Down-Regulation;EBV-associated disease;Environment;Epithelial Cells;Epithelium;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Equilibrium;Foundations;gammaherpesvirus;Gene Expression;Genetic Transcription;Genome;Genomic Segment;Genomics;Glutamine;Goals;Histones;HIV;Hodgkin Disease;Hospitals;Human;Human Herpesvirus 4;Immune Evasion;Infectious Mononucleosis;insight;Integration Host Factors;interdisciplinary approach;Knock-out;Knowledge;live cell imaging;Location;Lymphoma;Lytic;lytic gene expression;Lytic Phase;lytic replication;Lytic Virus;Malignant neoplasm of nasopharynx;Malignant Neoplasms;Mediating;medical schools;Membrane;Memory B-Lymphocyte;Methods;Microscopy;Molecular Conformation;Molecular Virology;Nasopharynx;Nasopharynx Carcinoma;Nervous System Disorder;novel therapeutic intervention;Nuclear Protein;Oral;oral infection;Oropharyngeal;pathogen;pathogenic virus;Phase;Population;post-transplant;programs;Proline;promoter;Protein Splicing;Proteins;reactivation from latency;Repression;Research;Resources;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Running;Saliva;Salivary;scientific atmosphere;Site;Stomach Carcinoma;Structure;Testing;Therapeutic;Tissues;Tonsil;Tonsillar Tissue;Training;transcription factor;Transcriptional Regulation;transcriptomics;transmission process;Untranslated RNA;Viral Genes;Viral Genome;viral genomics;Virus Diseases;virus host interaction;Virus Latency;Woman;Work

PROJECT_TITLE: Defining how the DNA- and RNA-binding protein SFPQ represses Epstein-Barr Virus lytic reactivation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07B-U(20)]


ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative Organelle tethering and mitochondrial membrane contact sites plays a central role in regulating the function and distribution of the mitochondrial network. Identifying the physiological functions of mitochondrial membrane contact sites and how they are regulated in space and time is relevant to public health as dysregulation of mitochondrial function plays key roles in human disease, such as neurodegeneration and cancer. Thus, the proposed research on mitochondrial membrane contact sites is relevant to the part of the NIH mission that seeks to advance fundamental knowledge that will lead to improvements in human health.

PI_NAMEs: CASLER, JASON  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Affect;Aging;Binding;Biochemical;Biocompatible Materials;Biological;Biology;career development;Cell membrane;Cells;chemical genetics;Communication;Complex;design;Development;Dissection;diversity and inclusion;Dynein ATPase;Educational process of instructing;environmental stressor;Ethics;fitness;Fluorescence Microscopy;Genes;Genetic;genetic approach;Goals;Group Meetings;Health;Homeostasis;Human;human disease;improved;Individual;interdisciplinary approach;Interdisciplinary Study;Knowledge;Learning;live cell imaging;Malignant Neoplasms;Mediating;Membrane;Mentorship;metabolome;Mission;Mitochondria;mitochondrial membrane;Molecular;Nerve Degeneration;novel;Nuclear;Organelles;Paper;Physiological;Play;Positioning Attribute;Process;programs;Proteins;Public Health;Regulation;Research;research and development;Research Personnel;Respiratory physiology;response;Role;Running;Saccharomyces cerevisiae;Saccharomycetales;Science;screening;Site;skill acquisition;skills;Stress;stressor;symposium;System;Techniques;Testing;Time;tool;Training;United States National Institutes of Health;Visualization;Work;Yeasts

PROJECT_TITLE: The Functions of Mitochondrial Membrane Contact Sites in Space and Time

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


PROJECT_TERMS: Acetyl-CoA Carboxylase;Acyltransferase;ADD-1 protein;alpha-glycerophosphoric acid;Apolipoproteins B;ATP Citrate (pro-S)-Lyase;Binding;cardiovascular risk factor;Cardiovascular system;Cholesterol;Co-Immunoprecipitations;Complement;Complex;Coronary heart disease;Cytoplasm;Cytosol;Data;density;Development;Dyslipidemias;Endoplasmic Reticulum;enzyme activity;Enzymes;Event;Fatty-acid synthase;gene synthesis;Genes;Genetic study;Goals;heart disease risk;Hepatic;Hepatocyte;hormonal signals;Hypertriglyceridemia;In Vitro;in vivo;Individual;inhibitor;insight;LDL Cholesterol Lipoproteins;lipid metabolism;Lipids;Lipoproteins;Liver;Location;Low-Density Lipoproteins;Metabolic;Metabolism;Mitochondria;mitochondrial membrane;Molecular;Multienzyme Complexes;Mus;New Agents;novel strategies;Organelles;Outcome;Palmitates;Physiological;Plasma;polymerization;Polymers;posttranscriptional;Production;Program Research Project Grants;protein protein interaction;Proteins;Regulation;Research Project Grants;Residual state;Risk;Role;Series;Signal Transduction;stem;Structural Protein;transcription factor;Triglycerides;Very low density lipoprotein

PROJECT_TITLE: Role of Multi-enzyme Complex in ApoBCL Secretion


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_NAME: DANA-FARBER CANCER INST

PHR: Narrative: Mutations in the epidermal growth factor receptor (EGFR) are a frequent cause of lung cancer. We are working to develop a new class of drugs that selectively target the mutant receptor by binding in a site that is different from existing drugs. In the long term these “allosteric” inhibitors, used alone or in combination with other EGFR- targeted drugs, should lead to more effective and better tolerated treatments for lung cancers caused by certain EGFR mutations.

PI_NAMEs: ECK, MICHAEL J (contact);GRAY, NATHANAEL SCHIANDER

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: acquired treatment resistance;Active Sites;Allosteric Site;Antibodies;Automobile Driving;Binding;Binding Sites;Biochemical;Biological Assay;Cancer Etiology;Cell model;Cetuximab;Chemicals;Clinical Trials;Combined Modality Therapy;design;Dimerization;drug discovery;Drug resistance;Drug Targeting;Enzymes;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Equilibrium;Erlotinib;Exhibits;Extracellular Domain;Family;Future;Gefitinib;Generations;Genetically Engineered Mouse;Goals;Grant;Human;human model;improved;In Situ;In Vitro;in vivo;inhibitor;innovation;Interdisciplinary Study;Ligands;Link;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Medicine;member;monomer;mouse model;multidisciplinary;mutant;Mutation;Non-Small-Cell Lung Carcinoma;novel;novel drug class;novel strategies;novel therapeutic intervention;Oncologist;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Phosphotransferases;Point Mutation;pre-clinical;prevent;Probability;Progress Reports;Protein Kinase;receptor binding;Resistance;resistance mechanism;resistance mutation;response;scaffold;Series;Site;Somatic Mutation;standard of care;Structural Biologist;Structure;success;synergism;targeted agent;targeted treatment;Testing;therapeutic development;Toxic effect;Translations;tumor;Tyrosine Kinase Domain;Tyrosine Kinase Inhibitor;Validation;Variant;Work;Xenograft Model

PROJECT_TITLE: Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


PHR: Modified Public Health Relevance Section  We are proposing to define immunologic mechanisms responsible for glycoconjugate vaccine processing and presentation leading to optimal T helper–cell reactivity. In this study, we will develop an understanding of the characteristics of glycopeptide epitopes presented by MHCII that induce potent antibodies that are highly efficacious in protecting against microbial infection. Our basic discoveries will lead to new, more effective glycoconjugate vaccines against important pathogens.

PI_NAMEs: KASPER, DENNIS L. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Affinity;Antibodies;Antibody Affinity;Antibody Avidity;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Attention;Avidity;Carbohydrates;Carrier Proteins;CD4 Positive T Lymphocytes;Cell Communication;Cells;Characteristics;Dendritic Cells;Disease;Egg Proteins;Elderly;Epitopes;Evaluation;Genetic Transcription;Glycoconjugates;Glycopeptides;Health Benefit;Helper-Inducer T-Lymphocyte;high risk;Immune;Immune response;Immunity;Immunization;Immunoglobulin G;Immunologics;Infection;Link;Mediating;Memory B-Lymphocyte;microbial;Modeling;mouse model;pathogen;Peptide Vaccines;Peptides;Polysaccharides;Population;Proteins;Proteomics;public health relevance;Recombinants;response;Role;Site;Streptococcus Group B;sugar;Surface;T-Cell Receptor;T-Lymphocyte;TCR Activation;Tularemia;vaccine immunogenicity;Vaccines;Work

PROJECT_TITLE: Elucidating the Structural Requirements for Next-Gen Glycoconjugate Vaccines

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


PI_NAMEs: HOBBS, HELEN HASKELL (contact)

PROJECT_TERMS: Acceleration;Affect;Angiopoietins;ANGPTL3 gene;antagonist;Antibody Specificity;Apolipoprotein E;Apolipoproteins B;Biochemical;Biological;candidate identification;Cardiometabolic Disease;cardiovascular risk factor;Cells;Cholesterol;Cholesterol Homeostasis;Clinical Trials;Complement;Complex;Coronary heart disease;Cultured Cells;Defect;Development;Disease;DNA Sequence;Enzymes;experimental study;Family member;Fatty Acids;Female;Functional disorder;Generations;Genetic;genetic approach;genetic manipulation;Genetic Screening;Genotype;Goals;Grant;Hepatic;Hepatocyte;Human;Hydrolysis;Hypertriglyceridemia;in vitro activity;in vivo;insight;Knockout Mice;Laboratories;Ligands;Link;Lipase;LIPG gene;lipid metabolism;Lipids;Lipoprotein (a);lipoprotein lipase;Lipoproteins;Liver;Location;Low-Density Lipoproteins;male;Mediating;Metabolic;Metabolic Pathway;Metabolism;Molecular;Mus;Mutation;Mycoplasma;New Agents;novel strategies;Pathway interactions;Peripheral;Pharmaceutical Preparations;Phenotype;Plasma;Plasmids;Post-Translational Protein Processing;Prevention strategy;Process;Program Research Project Grants;Property;protein function;Proteins;Published Comment;receptor;Research Project Grants;Residual state;Resolution;reverse genetics;Role;Route;routine screening;Sample Size;scavenger receptor;sex;stoichiometry;Structure;success;syndecan;Testing;therapeutic development;Tissues;Triglyceride Metabolism;Triglycerides;uptake;Variant;Very low density lipoprotein;Work

PROJECT_TITLE: Post-translational Control of Triglyceride and Cholesterol Metabolism by ANGPTL3 & ANGPTL8 in ApoBCL Clearance


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Metabolism plays a significant role in human physiology and pathology. A better understanding of this interplay may uncover opportunities that could be exploited therapeutically. We will test the concept that intermediary mitochondrial metabolism is a key regulator of RNA methylation, a newly recognized epigenetic modification that is abnormal in multiple human conditions.

PI_NAMEs: AGUIAR, RICARDO C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Agreement;alpha ketoglutarate;B-Lymphocytes;Biological Models;Biological Process;Cell Line;Cells;Chemicals;chromatin immunoprecipitation;Complex;control theory;Cysteine;Data;demethylation;Dioxygenases;Distal;DNA;DNA Methylation;Enzymes;Epigenetic Process;epitranscriptome;Exercise;field study;Gene Expression;Gene Expression Profile;Generations;Genetic Models;Genetic Transcription;Hexosamines;histone demethylase;histone methylation;Histones;Homeostasis;Human;human disease;Hypermethylation;In Vitro;in vitro Model;in vivo;Knowledge;Link;Location;loss of function;Mediating;Messenger RNA;Metabolism;Methylation;Methyltransferase;Mitochondria;mitochondrial metabolism;Mitochondrial RNA;Mixed Function Oxygenases;Modeling;Modification;mouse model;Mutation;novel;Nuclear;O-GlcNAc transferase;Organelles;Output;oxidation;Oxidoreductase;Pathology;Pathway interactions;Phenotype;Physiology;Play;Post-Translational Protein Processing;Production;Proliferating;Proteins;Reactive Oxygen Species;Reporter;Reporting;Research;RNA;RNA methylation;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Signal Transduction;Stem Cell Development;Testing;Therapeutic;Transcriptional Activation;Transgenic Mice;Work

PROJECT_TITLE: Mitochondrial 2-hydroxyglutarate dehydrogenases modulate the cellular epitranscriptome

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention

PHR: PROJECT NARRATIVE Multidrug-resistant (MDR) pathogens result in over 2.8 million potentially life-threatening infections in the United States annually. This proposal aims to establish how the microbes naturally associated with our bodies (i.e. our microbiome) protect against difficult-to-treat MDR pathogens. From this work, we will gain a clearer understanding of the factors that render the oral microbiome vulnerable to invading pathogens and will identify promising lead molecules for antibiotic drug development.

PI_NAMEs: ZELASKO, SUSAN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Aerodigestive Tract;Age;Animals;anti-microbial drug;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Autoimmune Diseases;Bacteria;bactericide;Caliber;Cardiovascular Diseases;career;Clinical;Clinical Skills;colonization resistance;Communication;comparative;Dangerousness;Disease;drug development;drug resistant microorganism;drug resistant pathogen;dysbiosis;efficacy testing;Environment;Evaluation Studies;fecal microbiome;Fractionation;Gatekeeping;Gene Cluster;Genome;Genomics;Genus staphylococcus;Growth;Health;health determinants;Human;Human Microbiome;human microbiota;immunoregulation;in vivo;Infection;insight;Integration Host Factors;Invaded;Laboratories;Lead;Life;Lower Gastrointestinal Tract;Mediating;Medical;Mentorship;metabolomics;Metadata;metagenome;metagenomic sequencing;Metagenomics;Microbe;microbial community;Microbiology;microbiome;microbiota;microorganism;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Natural Products;Nose;Oral;Oral cavity;oral microbial community;oral microbiome;oral streptococci;Participant;pathogen;Pathogenicity;Peptides;Periodicity;Pharmaceutical Preparations;Physicians;Play;polyketides;Population Heterogeneity;Predisposition;prevent;Prevention;Prevotella;Procedures;Production;reference genome;Research;Research Training;Resources;Respiratory System;Ribosomes;Risk Factors;Role;safety testing;Salivary;Sampling;Scientist;screening;Shapes;Shotguns;Site;small molecule;socioenvironmental factor;Source;Streptococcus;Structure;Swab;Testing;Therapeutic immunosuppression;United States;Universities;urban setting;Vancomycin resistant enterococcus;War;Wisconsin;Work

PROJECT_TITLE: Identification of antimicrobial specialized metabolites from the human oral microbiome to target multidrug-resistant pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07C-M(20)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Many animals exist in two different sexes which perform different behaviors. The sex of the brain and behavior are defined during development through discrete changes to neurons and circuit between the two sexes. Here, we will investigate how and when the brain-masculinizing transcription factor Fruitless acts on genes to establish the sex of the brain.

PI_NAMEs: BROVKINA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Adult;Afferent Neurons;Aggressive behavior;Anatomy;Animals;Applications Grants;Axon;axon guidance;Behavior;Behavioral;Bioinformatics;Biological Assay;Biological Metamorphosis;Brain;Brain region;brain size;career;Caring;cell type;Cells;Cellular biology;Chimeric Proteins;Chromatin;Chromatin Remodeling Factor;Communities;Complex;Courtship;Data;Development;Disparate;DNA Binding Domain;Doctor of Philosophy;Drosophila genus;Drosophila melanogaster;Educational Curriculum;Enhancers;Event;Female;Gene Expression;gene repression;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Genomics;Goals;Growth;in vivo;Insecta;Label;laboratory experience;Link;male;Maps;mating behavior;Men's Role;Mentors;Mentorship;Michigan;model organism;Molecular;Molecular Biology;Molecular Genetics;Morphology;multidisciplinary;Mutate;neural;neural circuit;Neuroanatomy;neuronal circuitry;Neuronal Differentiation;Neurons;Neurosciences;offspring;Organism;Output;Partner in relationship;Pathway interactions;Pattern;Physiology;Play;Population;Positioning Attribute;Productivity;programs;Proteins;recruit;Regulatory Element;Reporter;Reporting;Repression;Role;sensory input;sex;sex determination;Sex Differentiation;sexual dimorphism;Sexual Reproduction;Social Behavior;Specific qualifier value;Specificity;Synapses;synaptogenesis;System;Testing;tool;Training;transcription factor;Universities;Work;Writing

PROJECT_TITLE: Chromatin-based encoding of sex differentiation of neurons


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: NARRATIVE We plan to develop a radically new technology for molecular computation, whereby molecules themselves respond to external stimuli and produce output at the level of cellular phenotype, serving as nanocomputing agents (NCAs). Advent of such NCAs would revolutionize the interrogation of biological systems, enable a deeper understanding of human biology and disease, and facilitate development of in situ precision therapeutics.

PI_NAMEs: DOKHOLYAN, NIKOLAY  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Address;algorithm development;Algorithms;Binding;Biological;biological systems;Biology;Biotechnology;cell motility;Cells;Code;Communication;Complex;Computers;design;Development;Distal;Docking;Evaluation;flexibility;Growth;Human Biology;human disease;In Situ;insight;Libraries;Light;Maps;Methods;Modeling;Molecular;Molecular Computations;Molecular Conformation;nanoscale;new technology;novel;Output;Pathway interactions;Phenotype;Physiological;Precision therapeutics;Process;Programming Languages;Protein Engineering;Proteins;prototype;rational design;Reaction;Regulation;Research;RNA;Signal Pathway;Signal Transduction;Silicon;Site;small molecule;Speed;Stimulus;Structure;supercomputer;synthetic biology;Technology;Temperature;tool;Vertebral column;Writing

PROJECT_TITLE: Nanoscale programing of cellular and physiological phenotypes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-G(55)R]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Mental Illness;Prevention;Rehabilitation

ORG_CITY: PROVIDENCE

ORG_NAME: BUTLER HOSPITAL (PROVIDENCE, RI)

ORG_STATE: RI

PHR: PROJECT NARRATIVE  Mindfulness-Based Cognitive Therapy (MBCT) is an efficacious treatment for patients with depression and those at risk for depression relapse, though the processes through which MBCT achieves its outcomes are not well understood. By bringing together two parallel research literatures on basic cognition and cognitive biases in depression, this project aims to examine whether affective executive functioning serves as a mechanism of action of MBCT via a pilot randomized controlled trial. Better understanding how MBCT works will help us to better identify individuals who may benefit from MBCT and further personalize MBCT to target such processes directly.

PI_NAMEs: KRAINES, MORGANNE A (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Address;Adherence;Adult;Affect;Affective;arm;Attention;attentional bias;Back;Behavior;Clinical Trials;Code;Cognition;Cognitive;cognitive function;Communities;Computers;Conscious;daily functioning;Data Analyses;Depressed mood;depressive symptoms;Development;Disease;Educational workshop;efficacious treatment;Emotional;emotional stimulus;Environment;Executive Dysfunction;executive function;experience;Financial Hardship;General Population;Goals;Grant;Health;Health education;Home;Hospitals;Impairment;improved;Individual;information processing;innovation;Institution;Intervention;Knowledge;Literature;Major Depressive Disorder;Measures;meetings;member;Mental Depression;Mental Health;mental set;Mentors;Methods;Mind-Body Intervention;mind/body;mindfulness;mindfulness based cognitive therapy;mindfulness intervention;Mindfulness Training;Modeling;Monitor;Mood Disorders;National Center for Complementary and Integrative Health;Neurocognitive;novel;operation;Outcome;Participant;Patients;Personal Satisfaction;prevent;Process;programs;psychoeducation;Randomized;Randomized, Controlled Trials;recruit;reduce symptoms;Relapse;Research;Research Ethics;Research Methodology;Research Personnel;resilience;Risk;Schedule;Services;Severities;skills;Stimulus;Structure;symposium;System;Testing;theories;Time;Training;training opportunity;Treatment Protocols;Universities;Update;Work

PROJECT_TITLE: Affective Executive Functioning as a Mechanism of Mindfulness-Based Cognitive Therapy: A Pilot Randomized Controlled Trial


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Hearing Loss;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative About 15% of Americans have hearing loss due to noise exposure. Here, we propose to use in vivo imaging of the mouse cochlea to determine how auditory nerves are damaged by loud sounds. The findings of this research may ultimately support a clinical trial in human subjects that attempts to treat hearing loss during the few hours after blast or noise trauma.

PI_NAMEs: OGHALAI, JOHN S (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Acute;Affect;American;Anatomy;Auditory;Auditory Brainstem Responses;Auditory Threshold;base;Basilar Membrane;blast trauma;Cell Death;Cells;Clinical;Clinical Trials;Cochlea;Cochlear duct;cochlear synaptopathy;Data;Dendrites;Diameter;effective therapy;Endolymph;Endolymphatic Hydrops;excitotoxicity;Exposure to;extracellular;Functional disorder;Glutamates;Hair Cells;hearing impairment;hidden hearing loss;Hour;human subject;Image;Immunohistochemistry;Impairment;in vivo;in vivo imaging;innovation;Ions;Loudness;Measures;mechanical energy;Metabolic;Methodology;Mus;nerve damage;Nerve Fibers;neural;Neurons;Neurotransmitters;Noise;noise exposure;noise trauma;Noise-Induced Hearing Loss;Optical Coherence Tomography;Pathway interactions;Pattern;permanent hearing loss;Physiological;Physiology;pressure;Presynaptic Terminals;prevent hearing loss;Research;Residual state;response;ribbon synapse;Saline;Signal Transduction;SLC17A8 gene;sound;Surrogate Markers;Swelling;Synapses;Testing;Time;Transmission Electron Microscopy;Trauma;two photon microscopy;Water

PROJECT_TITLE: Mechanisms of cochlear synaptopathy after noise or blast trauma

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Menisci of the knee cushion our joints during normal loading, but are commonly injured. Unfortunately, healing of the meniscus in adults is limited, and current treatment options do not restore function, resulting in degeneration of the underlying cartilage. To address this, we engineer fibrous scaffolds with tailored release of factors that sequentially promote endogenous cell migration from the surrounding tissue and direct differentiation upon arrival at the wound site, and test these in a large animal model of meniscus repair.

PI_NAMEs: BURDICK, JASON A;MAUCK, ROBERT L (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Address;Adult;Animal Model;Animals;Biocompatible Materials;Cartilage;Cell Culture Techniques;cell motility;Cell Nucleus;Cells;Chemotactic Factors;Clinical;clinical translation;clinically relevant;cost;Cultured Cells;Data;Defect;Dense Connective Tissue;design;Development;Devices;directed differentiation;Dose;Drug Delivery Systems;Enabling Factors;Engineering;Ensure;Environment;Excision;Exposure to;Fiber;Formulation;functional restoration;Funding;healing;Health;Heterochromatin;Histone Deacetylase Inhibitor;Hyaluronic Acid;Implant;implantation;improved;In Vitro;in vivo;individualized medicine;injured;Injury;Instruction;Invaded;Joints;Knee;Mechanics;meniscal tear;meniscus injury;Meniscus structure of joint;Methods;Microfluidics;migration;Miniature Swine;Modeling;Musculoskeletal System;novel therapeutics;Nuclear;Patients;Pattern;Phenotype;Platelet-Derived Growth Factor;polycaprolactone;Polyethylene Glycols;Population;Porosity;pre-clinical;preservation;Production;Property;recruit;reduce symptoms;release factor;repair function;repaired;Role;scaffold;Signal Transduction;Site;subcutaneous;Surgical sutures;synergism;Technology;Testing;Thick;Time;Tissue Differentiation;tissue regeneration;tissue repair;Tissues;Transforming Growth Factor beta;transforming growth factor beta3;Trichostatin A;Work;wound

PROJECT_TITLE: Dynamic Fibrous Scaffolds for Repairing Dense Connective Tissues