ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: PROJECT NARRATIVE Understanding the mechanisms underlying physiological brain aging is essential for developing approaches to counteract cognitive decline and develop new therapies for neurodegenerative diseases. The goal of this highly collaborative project is to use novel integrated proteomics approaches to study protein stability and protein complexes and to elucidate the fundamental mechanisms of brain aging. This study will provide foundational data to understand the alterations observed in the aged brain proteome.

PI_NAMEs: FORNASIERO, EUGENIO FRANCESCO;JOVANOVIC, MARKO  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Adult;Affect;Age;age acceleration;age effect;age related;age related changes;aged;Aging;aging brain;Alzheimer's Disease;Animal Model;animal old age;Binding;Binding Proteins;Bioinformatics;Brain;Cell Aggregation;Cell Aging;Cells;Cerebellum;Complex;Complex Analysis;Dangerousness;Data;Deterioration;Development;Exclusion;experience;follow-up;Fractionation;Goals;Half-Life;Homeostasis;Human Pathology;Huntington Disease;Impaired cognition;Impairment;in vivo;insight;International;Intervention;juvenile animal;Label;Link;link protein;Macromolecular Complexes;Mammals;Measurement;Measures;Metabolic;misfolded protein;Molecular;Molecular Sieve Chromatography;monomer;multicatalytic endopeptidase complex;Mus;Nerve Degeneration;Neurodegenerative Disorders;novel;novel therapeutics;old mice;Parkinson Disease;Physiologic pulse;Physiological;Physiology;Polyribosomes;Population;Predisposition;Production;protein aggregation;protein complex;protein degradation;protein protein interaction;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;Research;Ribosomes;Risk Factors;Specificity;stoichiometry;Sucrose;Synapses;Tissues;Work;young adult

PROJECT_TITLE: Understanding protein turnover alterations in physiological brain aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Antimicrobial Resistance;Diabetes;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: DETROIT

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Public Health relevance Statement CDC reported that among the US population 34.2 million people of all ages—or 10.5% of the US population— had diabetes in 2018. Diabetic patients are known to have a higher incidence of infection, including microbial keratitis, with increased disease severity and higher rate of multi-drug resistance. The causes for increased susceptibility and rapid progression of microbial keratitis at cellular and tissue levels are elusive. Using Pseudomonas aeruginosa keratitis model of normal and diabetic mice in combination with RNA-seq and sophisticated bioinformatic, we propose to investigate biological processes that contribute to the defects in immune response and to identify means that reverse these adverse effects in diabetic corneas. CDC recently reported one death, three with permanent vision loss, and 55 people infected with antibiotic-resistant P. aeruginosa, linked to the use of EzriCare eye drops. Our proposed study is timely, clinically relevant, and will fill a major knowledge gap and lead to better treatment for infectious keratitis for the patients with or without diabetes.

PI_NAMEs: YU, FU-SHIN X (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Address;Adverse effects;Age;Antibiotic Resistance;Apoptosis;Arginine deiminase;Artificial Tears;Bacteria;Bacterial Infections;Bioinformatics;Biological Process;Blindness;CASP8 gene;Caspase;CD47 gene;Cell Death;Cells;Cessation of life;clinically relevant;Code;Cornea;corneal epithelium;Cytoplasmic Granules;Data;Defect;density;Deterioration;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;differential expression;Disease Outbreaks;DNA;effectiveness evaluation;Epithelial Cells;extracellular;Eye Infections;Eyedrops;Generations;Genes;Glucose;Goals;High-Throughput RNA Sequencing;Histones;Homeostasis;Human;human disease;Hyperglycemia;Immune;Immune response;Immunity;Impairment;improved outcome;In Situ Nick-End Labeling;In Vitro;Incidence;Infection;Infiltration;Inflammation;Inflammatory Response;inhibitor;Innate Immune Response;Insulin-Dependent Diabetes Mellitus;Invaded;Investigation;Keratitis;Knowledge;Leukocyte Elastase;Ligands;Link;Lytic;Macrophage;Measures;Mediating;methicillin resistant Staphylococcus aureus;microbial;Modeling;mRNA sequencing;Multi-Drug Resistance;Mus;Natural Immunity;Necrosis;neutrophil;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Obesity;Ontology;pathogen;Pathogenesis;Pathway interactions;Patients;Persons;Phagocytosis;Play;Population;Predisposition;Prevalence;prevent;Protein Family;Protein-Serine-Threonine Kinases;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;public health relevance;receptor;Receptor-Interacting Protein;Reporting;response;RIPK1 gene;RIPK3 gene;Role;Sepsis;Serine;Severities;Severity of illness;Stains;Staphylococcus aureus;Streptozocin;Testing;Tissue Preservation;Tissues;transcriptome sequencing

PROJECT_TITLE: Role of Programmed Cell Death Pathways in Bacterial Keratitis

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Endocrine Disruptors;Estrogen;Prevention;Women's Health Research

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Cancer remains to be a major challenge affecting men and women in their lifetime. Cancer risk and development can be influenced by environmental factors, diet and lifestyle. The link between commonly occurring environmental endocrine disruptors and their impact on breast cancer development could offer a new insight how and why environmental exposure of certain chemicals may impact public health.

PI_NAMEs: SUH, NANJOO  (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Animal Model;Animals;Biological Process;breast cancer diagnosis;Breast Cancer Model;breast cancer progression;Breast Cancer Risk Factor;cancer risk;cancer stem cell;carcinogenesis;Cell Culture Techniques;cell growth;Cellular Metabolic Process;Chemicals;Complex;consumer product;Development;developmental toxicity;Diet;disorder subtype;Endocrine Disruptors;Endothelial Cells;environmental chemical;Environmental Estrogen;Environmental Exposure;Environmental Risk Factor;Estrogen receptor positive;Estrogen Receptors;estrogenic;estrogenic activity;estrogenic endocrine disruptor;Estrogens;Exposure to;Fibroblasts;Goals;Health;Hormonal;Human;In Vitro;in vivo;insight;Life Style;Link;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary gland;Mammary Tumorigenesis;Mammospheres;MCF7 cell;men;Metabolism;metabolome;Modeling;Neoplasm Metastasis;novel;Outcome;Patients;phthalates;Proliferating;Property;Public Health;Receptor Signaling;reproductive toxicity;Role;Structure;Testing;timeline;Tissues;tumor;tumor growth;tumor metabolism;Tumor Promotion;tumor xenograft;Woman;Zeranol

PROJECT_TITLE: Influence of environmental endocrine disruptors and carcinogenesis

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Foodborne Illness;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: 8. Project Narrative The goal of this work is determine the mechanisms by which arsenic impairs the differentiation of stem cells into functioning motor neurons. This information will help to determine whether the current drinking water standard for arsenic is protective enough of human health.

PI_NAMEs: BAIN, LISA J (contact)

PROGRAM_OFFICER_NAME: HOLLANDER, JONATHAN

PROJECT_TERMS: Acetylcholine;Acetylcholinesterase;Ache;Adult;Arsenic;Brain;Cell Differentiation process;Cells;Choline O-Acetyltransferase;cholinergic;critical period;Data;Data Correlations;Dose;drinking water;Environment;Enzymes;Epidemiology;epidemiology study;exposed human population;Exposure to;Food;Future;Goals;Health;Human;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;Length;Messenger RNA;Motor;Motor Activity;motor deficit;motor impairment;motor neuron function;Motor Neurons;Movement;Muscle;Muscle Contraction;Muscle Weakness;Muscular Atrophy;nerve stem cell;nestin protein;neural;Neurites;neurobehavioral;Neuromuscular Junction;Neurons;Neuropathy;neurotransmitter release;neurotransmitter uptake;Neurotransmitters;perinatal period;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Physiologic pulse;Predisposition;Process;Production;protein biomarkers;protein expression;response;Rodent;Skeletal Muscle;skeletal muscle weakness;SOX1 gene;Specificity;stem;stem cell biomarkers;stem cell differentiation;Synaptosomes;Time;Transcript;transcriptome sequencing;uptake;Vesicle;vesicle transport;Western Blotting;Work

PROJECT_TITLE: Motor neuron formation is inhibited by arsenic

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Microbiome;Nutrition;Prevention;Urologic Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The proposed research is relevant to public health because it is focused on developing a new strategy to combat the incidence of salmonellosis in the US and to reduce the risk of carriage of antibiotic resistant Enterobacteriacea that are an increasingly important health issue. The proposal is focused on optimizing binding activity of type 1 fimbriae in E. coli Nissle 1917 as a probiotic strain that can outcompete pathogenic Salmonella strains for intestinal colonization in chickens. The project should lead to a reduction in Salmonella infectious diseases and provide alternatives to the usage of antibiotics to reduce these infections.

PI_NAMEs: JONES, BRADLEY D (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Address;Adherence;Agriculture;Alleles;Animals;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Adhesins;Bacterial Antibiotic Resistance;Binding;Biological Assay;Biological Models;carbapenem resistance;Cells;Chickens;Clinical;combat;Communicable Diseases;Consumption;cost estimate;Data;Domestic Fowls;egg;Engineered Probiotics;Engineering;Epithelial Cells;Escherichia coli;Exclusion;Food Safety;foodborne illness;Gene Cluster;Gene Expression;Genes;Goals;Gram-Negative Bacteria;gut colonization;gut microbiome;hatching;Health;Hospitalization;Human;human disease;improved;Incidence;Infection;infection risk;intestinal epithelium;Intestines;Invaded;Link;Macrophage;Meat;Mediating;Multi-Drug Resistance;Mutagenesis;novel strategies;Organism;pathogenic bacteria;Pathogenicity;Pathogenicity Island;Plasmids;Play;Positioning Attribute;Probiotics;Proteins;Public Health;Receptor Cell;Research;resistant strain;Risk Reduction;Role;Salmonella;Salmonella infections;Salmonella typhimurium;Source;Specificity;Surface;Testing;type 1 fimbriae;United States;United States Department of Agriculture;United States National Institutes of Health;Virulence;Virulence Factors;Work

PROJECT_TITLE: Influence of an E. coli hyperadherent probiotic on Salmonella intestinal colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_DEPT: PLASTIC SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health because it will facilitate and vertically advance the development of critically needed medical countermeasures against chemicals induced skin injuries. The proposed mechanistic studies will facilitate understanding the dynamics of the key processes involved in the chemicals induced injuries that will have an enormous impact on our capabilities to design countermeasure strategies and test them directly on human skin using our novel model system. This whole process will shorten the time for developing countermeasure and increase the chances of success in clinical translation Thus, the proposed research is relevant to the NIH/NIAID/Chemicals Countermeasure Program’s mission to develop new countermeasures and add them to the national stockpile.

PI_NAMEs: EJAZ, ASIM  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Abdomen;Acceleration;adiponectin;adipose derived stem cell;Advanced Development;Anatomy;Apoptosis;Apoptotic;Appearance;Area;Arsenicals;arsine;Biological Models;Bioreactors;Blood Vessels;Bulla;Cannulations;CASP3 gene;Cell Death;cell injury;Cell Nucleus;Cell Separation;cell type;Cells;Characteristics;Chemical Agents;chemical countermeasure;Chemical Injury;Chemicals;Cicatrix;Clinic;Clinical;clinical translation;Collaborations;Consumption;Controlled Environment;Dermal;design;Development;DNA Damage;Dose;Down-Regulation;efficacy testing;Ensure;Environment;Erythema;Evaluation;experience;Exposure to;Extracellular Matrix;Fibroblasts;Fibrosis;Fresh Tissue;Funding;Future;Gene Expression;Gene Expression Profiling;Genes;Glucose;Goals;Guidelines;Histologic;Hour;Human;Human Resources;human tissue;In Situ Nick-End Labeling;Inflammation;Injury;innovation;insight;Knowledge;Laboratories;Legal patent;Mechlorethamine;medical countermeasure;Metabolic;Metformin;Mission;Modeling;Molecular;Monitor;mouse model;Mus;National Institute of Allergy and Infectious Disease;Necrosis;novel;novel therapeutics;Operative Surgical Procedures;Outcome;Oxides;Pain;Pathway interactions;Perfusion;Physiological;Plastic Surgical Procedures;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;pressure;Probability;Process;Production;programs;Proliferating;Protective Devices;Proteins;Public Health;Quality of life;Radiation;Reaction;Reporting;Research;research clinical testing;Research Support;response;response to injury;Risk;screening;single cell sequencing;Site;Skin;skin fibrosis;Skin injury;Skin wound healing;Specimen;Stains;Stimulus;success;Symptoms;System;Temperature;Testing;Time;tissue injury;Tissue Viability;Tissues;tool;Toxic effect;Toxicant exposure;Training;Training Programs;Translations;United States National Institutes of Health;vasoconstriction;Vasodilation;Vesicants;wasting;weapons of mass destruction;wound healing

PROJECT_TITLE: Explant human skin perfusion model to study mechanisms of chemical injury and mitigation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (02)]


ADMINISTERING_IC: AG

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DURHAM

ORG_NAME: NORTH CAROLINA CENTRAL UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Developing easy-to-use and low-cost assays with high sensitivity and specificity to detect early Alzheimer's disease (AD) and differentiate AD from other related dementias is urgent unmet need. We will develop novel biofluid misfolded tau protein-based molecular biomarkers for early AD diagnosis and for differentiating AD from other tauopathies. Our work may lead to significant clinical and translational advances in AD and ADRD medical diagnosis and related healthcare.

PI_NAMEs: WU, LING  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Antibodies;Autopsy;biobank;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker panel;biomarker validation;Brain;Brain imaging;Brain region;brain tissue;Cerebrospinal Fluid;Characteristics;Clinical;clinical diagnosis;Cognitive;cohort;Communities;cost;Dementia;detection test;Development;Diagnosis;Diagnostic;Diagnostic Specificity;Diagnostic tests;Differential Diagnosis;Disease;early detection biomarkers;Early Diagnosis;effectiveness evaluation;Enzyme-Linked Immunosorbent Assay;Frequencies;Goals;Healthcare;Human;human old age (65+);Image;Imaging Device;Impaired cognition;improved;Intervention;Medical;Methods;Microscopic;mild cognitive impairment;minimally invasive;molecular array;molecular marker;Monitor;neurocognitive test;Neurology;novel;Pathologic;Patients;Performance;Persons;Pharmacotherapy;Plasma;Positron-Emission Tomography;Process;Progressive Disease;Radioactive Tracers;Rare Diseases;Registries;repository;Sampling;Scanning;screening;Senile Plaques;Sensitivity and Specificity;Severity of illness;single molecule;Site;Symptoms;tau aggregation;tau Proteins;tau-1;Tauopathies;Technology;technology development;Testing;Time;Translating;Translations;United States;Work

PROJECT_TITLE: New biomarkers for early Alzheimer's diagnosis and tauopathy differentiation

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ORG_DEPT: PATHOLOGY

PHR: Project Narrative During infection, lung sensory neurons play an important role in primary host defense by triggering coughing, but how they modulate inflammation in the lung is incompletely understood. On the other hand, dendritic cells (DCs) play a crucial role in immunity by sensing pathogens and activating T cells. By using a mouse model of helminth infection, the goal of this project is to understand how DCs and sensory neurons cooperate in orchestrating type 2 inflammatory responses in the lung.

PI_NAMEs: KUMAMOTO, YOSUKE  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Ablation;adaptive immune response;adaptive immunity;Afferent Neurons;airway hyperresponsiveness;Allergens;Anatomy;antigen-specific T cells;Antigens;Asthma;asthma model;behavioral response;Calcitonin Gene-Related Peptide;Cells;Chemicals;Circulation;clinically relevant;Coughing;cytokine;Data;defense response;Deglutition;Dendritic Cells;Dermal;detection platform;Development;Disease;egg;Fibrosis;Gene Expression;Genes;Goals;Health;helminth infection;Helminths;Hemorrhage;Hookworm Infections;Hookworms;Host Defense;Human;Hypersensitivity;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunologics;In Vitro;Infection;Inflammation;Inflammatory Response;Innate Immune Response;Interleukin-4;Intestines;Invaded;Larva;Leucocytic infiltrate;Leukocytes;Life Cycle Stages;Lung;migration;Modeling;mouse model;Mus;Mycoses;Nematoda;Neurons;Neuropeptides;Nippostrongylus;Nociception;Organ;Pain;Parasites;pathogen;Peripheral;Play;Process;Production;Pruritus;pulmonary function;Pulmonary Inflammation;Regulation;Research Proposals;restraint;Role;sensor;Site;Skin;Small Intestines;Sneezing;Source;Staphylococcal Infections;T-Cell Activation;Testing;Th2 Cells;TRPV1 gene

PROJECT_TITLE: Regulation of lung inflammation by crosstalk between dendritic cells and sensory neurons

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Patient Safety;Prevention

ORG_CITY: MINNEAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Immune effector cell-associated neurotoxicity syndrome (ICANS) is a cluster of symptoms associated with immunotherapy that did not show up in pre-clinical studies but has been found in 40-90% of the people undergoing immunotherapy as part of cancer treatment. In this project we will develop technology that will enable frequent automated monitoring of the patients’ cognitive status in order to detect early subtle symptoms of ICANS. If detected early, ICANS can be treated and prevented from progressing to more severe symptoms including brain swelling, coma and, in rare cases, death.

PI_NAMEs: BACHANOVA, VERONIKA S (contact);PAKHOMOV, SERGUEI VS

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Artificial Intelligence;associated symptom;Attention;Brain Edema;Cancer Patient;cancer therapy;CAR T cell therapy;Caring;Cell Therapy;Cessation of life;chatbot;chimeric antigen receptor T cells;Classification;Clinical;Clinical Pharmacology;Clinical Protocols;Clinical Research;Clinical Trials;Cognitive;cognitive testing;Coma;Complication;computer human interaction;Confusion;cost effective;Data;debilitating symptom;design;Detection;diagnostic accuracy;diagnostic tool;Dose;Dysgraphias;Early Diagnosis;Early identification;early screening;Early treatment;effective therapy;Effector Cell;Encephalopathies;Exhibits;Expressive Aphasia;Fright;Generations;Goals;Hematology;Hour;Human;Immune;immune effector cell-associated neurotoxicity syndrome;Immunologic Monitoring;Immunological Diagnosis;Immunotherapeutic agent;Immunotherapy;Impaired cognition;improved;Individual;Infusion procedures;Inpatients;Institutional Review Boards;Intubation;Language;Learning;Measurement;Memory;Memory impairment;Modality;Modeling;Monitor;Motor;multidisciplinary;Natural Language Processing;Neurobehavioral Manifestations;Neurocognitive;neurocognitive test;neurotoxicity;novel strategies;Outcome;Patient Monitoring;patient response;Patient Selection;Patients;Persons;Positioning Attribute;preclinical study;prevent;prospective;Protocols documentation;Provider;Public Health Informatics;random forest;response;Risk;risk minimization;Safety;screening;Sensitivity and Specificity;Severities;Short-Term Memory;software development;Specificity;Speech;standard of care;Steroids;Stimulus;Stress;symptom cluster;Symptoms;Systems Analysis;Technology;Telephone;Testing;therapy outcome;Time;transmission process;verbal;Work

PROJECT_TITLE: Improving safety and access to immune effector cell therapy with artificial intelligence technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-Z (90)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Malaria parasites resistant to first-line artemisinin-based combination therapies (ACT) have emerged in East Africa. Patients who have been treated with ACT may harbor drug resistant parasites at low levels one month following treatment. This study will find whether these low level infections are transmissible to mosquitoes and contribute to the spread of antimalarial resistance.

PI_NAMEs: LIN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Africa;Africa South of the Sahara;Aftercare;Alleles;Anopheles gambiae;Anti-malarial drug resistance;Anti-malarials;artemether;Artemisinins;benflumetol;Biological Assay;Blood;Blood specimen;Cambodian;Cessation of life;Child;Clinical;Combined Modality Therapy;cost;Country;Culicidae;design;Detection;Dose;Drug resistance;Failure;feeding;fitness;follow-up;Frequencies;Genetic Polymorphism;Human;in vivo;Individual;Infection;insight;Interruption;Legal patent;Low Prevalence;Malaria;Measures;Membrane;Microscopy;mosquito-borne;Mutation;novel;Parasite resistance;Parasitemia;Parasites;Patients;Persons;Pharmaceutical Preparations;Plasmodium falciparum;prevent;Primaquine;Recurrence;recurrent infection;Regimen;Reporting;Resistance;resistance allele;resistance mutation;Risk;Rwanda;Safety;Salivary Glands;Site;Sporozoites;Symptoms;Tanzania;Therapy trial;Time;transmission process;treatment comparison;treatment duration;Treatment Failure;vector

PROJECT_TITLE: Measuring the transmissibility of recurrent parasitemias that arise following artemisinin-based combination therapy

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Chronic Liver Disease and Cirrhosis;Dementia;Digestive Diseases;Liver Disease;Neurodegenerative;Neurosciences;Nutrition;Obesity

ORG_CITY: CLAREMONT

ORG_NAME: KECK GRADUATE INST OF APPLIED LIFE SCIS

ORG_STATE: CA

PHR: PROJECT NARRATIVE Obesity and high fat/sugar diet are risk factors of Alzheimer’s disease (AD), which is the sixth leading cause of death in the United States. The mechanisms underlying obesity-induced AD are not completely understood. Obesity significantly affects the liver, but the relationship between obesity-induced liver damage and AD pathology is poorly understood. Our proposal explores how obesity-induced liver changes affect the brain to induce and/or exacerbate AD.

PI_NAMEs: HAN, DERICK S (contact);SUMBRIA, RACHITA

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Alcohols;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Area;beta-site APP cleaving enzyme 1;Brain;C57BL/6 Mouse;Cause of Death;cerebral amyloidosis;Cerebrum;Chronic;Circulation;Cirrhosis;Cognition;Data;Dependovirus;Diet;dietary control;Disease Marker;Down-Regulation;Etiology;Fatty acid glycerol esters;Fatty Liver;feeding;Gene Expression;genetic manipulation;Gliosis;Goals;Hepatic;Homeostasis;Human;Human Amyloid Precursor Protein;Impairment;Insulinase;Investigation;knowledge of results;Link;Lipoprotein Receptor;Liver;Liver diseases;liver injury;MicroRNAs;Mus;Neprilysin;neuron loss;new therapeutic target;nonalcoholic steatohepatitis;Obese Mice;Obesity;overexpression;Pathologic;Peripheral;presenilin;Protein Overexpression;Proteins;Proteomics;receptor;Research;Satellite Viruses;Source;Specialist;Sucrose;sugar;tau-1;Techniques;United States;Viral Vector;western diet

PROJECT_TITLE: The impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer’s disease pathology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: The project is aimed at finding pre-diagnosis biomarkers for Age-related Macular Degeneration - features of blood samples which may predict whether the donors will develop the disease. The goal will be achieved by analyzing stored blood samples, obtained from donors, years before the disease becomes detectable. Such markers will facilitate faster discovery of treatments, which currently do not exist for the most frequent forms of the disease.

PI_NAMEs: BLENKINSOP, TIMOTHY A. (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Affect;Age;age related biomarkers;Age related macular degeneration;aptamer;Area;Award;biobank;Biological Markers;biomarker discovery;Blood;Blood Donations;Blood specimen;chemical bond;Clinical;Color Visions;cost;data acquisition;Developed Countries;Development;Diagnosis;Diagnostic;diagnostic biomarker;dietary supplements;Disease;disorder prevention;DNA;Dryness;effective intervention;Elderly;Electronic Health Record;Environmental Risk Factor;Exclusion;Exudative age-related macular degeneration;Fingerprint;Funding;Genetic;genetic information;genetic risk factor;Genetic study;Genotype;geographic atrophy;Goals;high reward;high risk;Incidence;Individual;innovation;Intelligence;Intervention;Laboratories;Life Style;Link;Longitudinal Studies;macula;Measures;medical schools;Methods;multiplex assay;Nonexudative age-related macular degeneration;optical spectra;Patients;Persons;Phase;Plasma;Plasma Proteins;predictive marker;Predisposing Factor;Prevalence;prevent;Prevention;Prevention strategy;Preventive therapy;Primary Open Angle Glaucoma;Proteins;Proteomics;Publishing;Reporting;repository;research clinical testing;Research Design;Research Personnel;Retinal Degeneration;Sampling;Spectroscopy, Fourier Transform Infrared;Subjects Selections;success;United States;United States National Institutes of Health;Vascular Endothelial Growth Factors;Visual Acuity;Visual impairment

PROJECT_TITLE: Pre-diagnosis Biomarker Discovery for Age-Related Macular Degeneration


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHIATRY

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Following a randomized controlled trial of a parenting intervention with Congolese mothers of infants/toddlers experiencing significant adversity, we now propose a follow-up study of these participants to evaluate the long- term effect of a parenting support program on child mental health outcomes at school age, and test the impacts of social family, maternal mental health, and child growth factors as predictors of longer-term child mental health. A significant strength of our assessment plan includes leveraging our prior extensive phenotyping of environmental, social, caregiving, developmental, and medical risk/resilience factors (assessed in early childhood) and the new array of questionnaire-based and eye tracking response (to emotion-laden video content) assessments of child mental health. Characterizing how early childhood parenting support enhances child mental health, along with the family social, child growth, and maternal mental health factors driving this process will inform prevention of child mental health problems in low- and middle-income countries (LMICs).

PI_NAMEs: BOIVIN, MICHAEL JOSEPH (contact);FAMILIAR-LOPEZ, ITZIAR

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: 12 year old;Affect;age related;anxiety symptoms;Area;arm;Automobile Driving;Behavior;Behavioral;behavioral outcome;caregiver education;caregiver interventions;Caregivers;caregiving;Child;Child Development;Child Mental Health;Child Rearing;Childhood;Clinical Trials;community organizations;Competence;Congo;Data Analyses;Democratic Republic of the Congo;depressive symptoms;Development;Distress;early childhood;emotion regulation;Emotional;Emotions;Environment;executive function;experience;Family;Family dynamics;follow up assessment;follow-up;Follow-Up Studies;Food;Future;Growth;Growth Factor;Health Benefit;HIV;improved;Infant;Informal Social Control;Intercept;Intervention;Learning;Link;Long-Term Effects;low and middle-income countries;Measures;Mediator;Medical;member;Mental disorders;Mental Health;middle childhood;Mothers;neurodevelopment;Orphan;Outcome;parenting intervention;Parents;Participant;Performance;Phenotype;Prevention;Prevention program;Problem behavior;Process;programs;Psychopathology;psychosocial;Quality of Care;Questionnaires;Randomized;Randomized, Controlled Trials;resilience factor;response;Risk;Role;Rural;School-Age Population;Schools;Self Efficacy;social;social communication;social factors;South Africa;Testing;therapy development;Time;Toddler;treatment as usual;Uganda;United States National Institutes of Health;Video Recording;visual tracking;Water

PROJECT_TITLE: Congolese mother and child mental health in response to early child development interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-C (01)]


ADMINISTERING_IC: HD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_CITY: STILLWATER

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: PROJECT NARRATIVE/RELEVANCE STATEMENT Uterine NK (NK) cells within the uterine-placental interface contribute to the modification of uterine vasculature and its failure may result in pregnancy related pathologies. Deeper understanding of the uterine NK cells biology during pregnancy will lead to the discovery of strategies for early detection of pregnancy failures and therapeutic intervention.

PI_NAMEs: IQBAL, KHURSHEED  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Abruptio Placentae;Address;Alleles;Biological;Biology;Blood;Candidate Disease Gene;Cell Count;Cell Lineage;Cells;Cellular biology;Classification;Communities;Cre driver;CRISPR/Cas technology;Decidua Basalis;Deposition;Development;Developmental Process;Early Diagnosis;early pregnancy loss;Ensure;Enterobacteria phage P1 Cre recombinase;Environment;Etiology;Evaluation;Event;Experimental Models;experimental study;Failure;fetal;Fetal Development;Fetal Growth;Fetal Growth Retardation;Fetus;Gases;Generations;Genes;genome editing;Health;healthy pregnancy;High-Risk Pregnancy;Human;Immune;Inferior;Infiltration;Interferon Type II;Invaded;Knock-in;Link;LoxP-flanked allele;Macrophage;Maternal-Fetal Exchange;migration;Missouri;Modeling;Modification;Molecular;Mothers;Mus;Natural Killer Cells;novel;Nutrient;Organ;Pathology;Phenotype;Placenta;Placental Biology;Placentation;Play;Population;postnatal;Pre-Eclampsia;Pregnancy;pregnancy failure;Premature Birth;Rat Strains;Rat Transgene;Rattus;Regulation;Research;Resources;Role;Science;Sentinel;Shapes;Spiral Artery of the Endometrium;Therapeutic Intervention;Tissues;tool;trophoblast;trophoblast stem cell;United States National Institutes of Health;Universities;Use Effectiveness;Uterus;Vascular remodeling;Villous

PROJECT_TITLE: Rat model for investigating NK cells at the uterine-placental interface

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Genetics;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases

ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

ORG_STATE: TX

PHR: Project Summary This new R21 application “Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue” will provide novel insights into the role of tissue non-specific alkaline phosphatase (TNSALP) on lung development and function. Hypophosphatasia (HPP) is an inherited disorder of mineral metabolism in patients with loss of function mutations in the tissue-nonspecific alkaline phosphatase gene (ALPL). This disorder is associated with high neonatal morbidity and mortality, impaired musculoskeletal development, and respiratory distress syndrome (RDS), yet the in utero origins of the disease are unknown and the ontogeny of development of lung pathology is poorly understood. The PI’s laboratory developed the first large animal model of HPP in sheep, creating an ALPL gene mutation in exon 10 (c.1077C>G) recapitulating the human HPP phenotype. As observed in human patients, but not in mice, neonatal lambs carrying a loss of function mutation in ALPL commonly have respiratory complications as neonates and have an increased incidence of pneumonia compared to wildtype control lambs throughout life. Preliminary findings in HPP sheep demonstrate severe lung pathology on Day 100 of gestation (GD100), suggesting programming of the postnatal lung phenotype during fetal development, and that the known postnatal respiratory complications result from more than insufficient rib cage mineralization. This sheep HPP model will be used to test the hypothesis that reduced TNSALP activity causes lung-specific developmental abnormalities, as well as deficiencies in diaphragm structure and respiratory function that contribute to RDS by the analyses of WT and HPP fetuses on GD130 and in lambs at 4 months of age. Specific Aim 1 will characterize the respiratory phenotype in WT and HPP sheep throughout development (GD130 and postnatal 4 months of age). Specific Aim 2 will determine the impact of HPP on resting lung function in 4 month old WT and HPP sheep by measuring arterial blood gases (pO2, pCO2), bicarbonate, pH, ammonia and lactate, and bronchoalveolar lavage (BAL). Specific Aim 3 will determine the efficacy of recombinant TNSALP therapy to rescue the developmental respiratory phenotype in HPP sheep using lentiviral GFP control or ALPL-GFP constructs injected into WT or HPP sheep zygotes. This interdisciplinary collaborative team includes a current clinical veterinary physiologist collaborator (an expert on respiratory diseases in ruminants) who will collect arterial blood and bronchoalveolar lavage fluids for assessment of lung pathophysiology. This study will provide the first investigations into the in utero developmental origins of the severe respiratory phenotype in sheep with HPP, and describe contributions of non-skeletal tissues (lung, lung-resident immune cells, diaphragm) to RDS in HPP. These findings will have immediate relevance to the management of RDS in human HPP.

PI_NAMEs: GADDY, DANA  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Age;Age Months;Alkaline Phosphatase;Alveolar;Ammonia;Anesthesia procedures;Animal Model;Architecture;Bacterial Infections;Bicarbonates;Birth;Blood;Blood gas;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Candidate Disease Gene;candidate validation;Cells;Clinical;Conceptus;CRISPR/Cas technology;Development;Disease;efficacy evaluation;Etiology;Exons;Exploratory/Developmental Grant;Fetal Development;Fetal Lung;Fetus;Functional disorder;Gene Mutation;gene therapy;Genes;Growth;Hereditary Disease;Histology;Human;Hypophosphatasia;Immune;Impairment;in utero;Incidence;Individual;Inflammation;Inflammatory;innovation;insight;Investigation;Laboratories;Life;loss of function mutation;Lung;lung development;Measures;Metabolism;mineralization;Minerals;Modeling;mouse model;Mus;Musculoskeletal Development;Musculoskeletal System;Neonatal;neonatal morbidity;Neonatal Mortality;neonate;novel;Pathogenesis;Patients;Phase;Phenotype;Pneumonia;Positioning Attribute;postnatal;Postnatal respiratory distress;Pregnancy;Protein Analysis;pulmonary function;Pulmonary Pathology;Recombinants;Reporting;Respiration;respiratory;Respiratory Diaphragm;Respiratory Disease;Respiratory distress;respiratory distress syndrome;Respiratory physiology;Rest;Rewards;rib bone structure;Risk;Role;Ruminants;Sheep;sheep model;single-cell RNA sequencing;Structure;Testing;Time;Tissues;Veterinarians;zygote

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project narrative A number of age-related neurodegenerative disorders including Alzheimer’s disease is associated with the amyloid aggregation which involves the formation of oligomers that are difficult to study using standard structural biology techniques. Two-dimensional infrared spectroscopy (2D IR) is an emerging technology uniquely suitable for elucidating the structure and tracking the kinetics of toxic oligomers, but it relies on simulations that connect structural models and experimental spectra. The aim of this proposal is to develop and implement methods and algorithms for calculating 2D IR spectra from coarse-grained protein and implicit solvent models.

PI_NAMEs: KANANENKA, ALEXEI  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;age related;age related neurodegeneration;aggregation pathway;Agreement;Algorithms;Alzheimer's Disease;Amber;Amides;Amyloid;Amyloid Fibrils;amyloid formation;Amyloid Proteins;Amyotrophic Lateral Sclerosis;Binding Proteins;Cause of Death;Cell membrane;Charge;chemical bond;Complex;Computational algorithm;Computer Simulation;Computer software;Computing Methodologies;cost;Crowding;Data;Descriptor;Dimensions;Disease;electric field;Emerging Technologies;Environment;experimental study;Failure;Frequencies;frontier;Grain;improved;infrared spectroscopy;insight;interest;Isotope Labeling;Kinetics;Length;Libraries;Light;Machine Learning;magnetic field;Measures;Membrane;Methodology;Methods;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;Nervous System Disorder;neuron loss;neurotoxic;neurotoxicity;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Nuclear Magnetic Resonance;Parkinson Disease;Pathology;Persons;Phase;Physiologic pulse;Population;Prion Diseases;programs;protein aggregation;Protein Dynamics;Proteins;Protocols documentation;Resolution;Sampling;self assembly;Senile Plaques;Shapes;simulation;simulation software;Site;software development;Solvents;Spectrum Analysis;Speed;structural biology;Structural Models;Structure;System;Techniques;Technology;temporal measurement;Testing;theories;Time;Tissue imaging;tool;two-dimensional;United States;vibration;Work;X-Ray Crystallography

PROJECT_TITLE: Algorithms and Software for Multidimensional Vibrational Spectroscopy of Coarse-Grained Protein Models

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Lung

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Project Narrative Chronic exposure to airborne particles could lead to debilitating pulmonary inflammation and subsequent development of several chronic diseases, making it important to develop new strategies to resolve lung inflammation and prevent disease development. We propose to study the kinetic production of extracellular vesicles (EV) and their miRNAs cargos in the lung after particle exposure using an advanced analytical system to gain better understanding of how EV can mediate cell-cell communication and contribute to inflammation resolution. Our exploratory work can help reveal the potential roles of the EVs derived from selected pulmonary cells in anti-inflammation, immunomodulation, and/or airway epithelium protection, which could be leveraged for developing effective tools to reduce the burden of chronic airway inflammatory diseases.

PI_NAMEs: ADAMCAKOVA-DODD, ANDREA  (contact);WANG, YINSHENG

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;advanced analytics;Air Pollution;airway epithelium;analytical tool;Anti-Inflammatory Agents;Asthma;Biological Models;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Cell Communication;Cell secretion;cell type;Cells;chemokine;Chronic;Chronic Disease;Chronic Obstructive Pulmonary Disease;chronic respiratory disease;Communication;Consumption;cytokine;Detection;Development;Disease;Environment;Environmental Hazards;Epithelial Cells;Epithelium;exosome;Exposure to;extracellular;Extracellular Space;extracellular vesicles;fine particles;Flow Cytometry;Future;Gene Expression;Goals;Heterogeneity;Immune;immunoregulation;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;Inhalation;innovation;Kinetics;Knowledge;Lipids;Lung;lung injury;Macrophage;Mediating;Membrane;MicroRNAs;Modeling;Monitor;Mus;nanoparticle;neutrophil;Nucleic Acids;particle;particle exposure;Particulate Matter;Phase;Population;prevent;Production;Proteins;Pulmonary Inflammation;Regulation;Resolution;Respiratory Disease;response;Role;Sampling;Sensitivity and Specificity;Signaling Molecule;Smoking;Source;Stimulus;Structure of parenchyma of lung;Subgroup;success;System;Techniques;therapeutic development;Time;tool;treatment strategy;Ultrafine;ultrafine particle;Vesicle;vesicular release;Work

PROJECT_TITLE: The Role of Extracellular Vesicles in Pulmonary Inflammation

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Nutrition

ORG_DEPT: GENETICS

PHR: Narrative We propose mechanisms t o study the pathological aging in both adipose and brain tissues to identify the common molecular  associated with pathological aging. We will also identify gene regulations putatively involved in adipose-brain cross-tissue talk and experimentally validate them using mouse models.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Address;Adipose tissue;Age;age-related disease;Aging;aging mechanism;aging related;Alzheimer's Disease;Alzheimer's disease model;Animal Model;Biological;Biology of Aging;Brain;brain tissue;Candidate Disease Gene;Classification;Cognition;cognitive function;cohort;Communication;Complex;Data;Development;Diet;diet-induced obesity;dietary control;Disease;Elderly;experimental study;Fatty acid glycerol esters;Foundations;frontal lobe;gene conservation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;genetic signature;Genotype-Tissue Expression Project;Geroscience;Goals;healthy aging;Heterogeneity;High Fat Diet;Hippocampus;Human;Human body;human tissue;innovation;insight;interest;Investigation;Learning;Link;Mediating;Metabolic;Metabolic Diseases;Molecular;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;Non-Insulin-Dependent Diabetes Mellitus;normal aging;novel;Organ;Organ Model;Pathologic;Pathologic Processes;pathological aging;Peripheral;Prefrontal Cortex;prevent;Risk Factors;subcutaneous;Subgroup;Testing;Tissue-Specific Gene Expression;Tissues;transcriptome;transcriptomics;Transplantation;Validation;Visceral;Work

PROJECT_TITLE: Molecular mechanisms of pathological aging of human brain and adipose and their inter-organ communication

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The current pandemic of COVID-19, caused by SARS-CoV-2, has led to tremendous damage to all aspects of our society. The goal of this project is to identify host or viral RNA 2’-O methyltransferases (MTases) that install internal 2’-O methylation in SARS-CoV-2 RNA and to explore the biological functions of internal 2’-O methylation in SARS-CoV-2 RNA. Understanding these fundamental questions will facilitate the development of therapeutic agents by targeting 2’-O methyltransferases and internal 2’-O methylation.

PI_NAMEs: LI, JIANRONG  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;Affinity Chromatography;base;Bioinformatics;Biological Process;Biology;bronchial epithelium;Catalysis;Cells;Collaborations;Complementary DNA;Complex;COVID-19 pandemic;current pandemic;Data;Dengue Virus;Diamond;Discrimination;Disease;Ebola virus;Enzymes;Epigenetic Process;Eukaryota;Gene Expression;Goals;Guanine;HIV;Human;hydroxyl group;Hydroxyl Radical;IFIH1;Immune;Innate Immune Response;Interferons;Maps;Mass Spectrum Analysis;Messenger RNA;methyl group;Methylation;Methyltransferase;Modification;Molecular Profiling;mRNA capping;mRNA Translation;Mutate;Natural Immunity;Nucleosides;Nucleotides;Play;Positioning Attribute;prevent;Property;Proteins;Recombinants;Resolution;reverse genetics;Ribose;Ribosomal RNA;RNA;RNA Caps;RNA metabolism;RNA Processing;RNA Stability;RNA Viruses;RNA-Protein Interaction;Role;sensor;Site;Societies;Structure;System;targeted treatment;Techniques;Testing;therapeutic development;Time;Transcript;Transfer RNA;Translations;Viral;Viral Genes;Viral Nonstructural Proteins;viral RNA;Virus;Virus Diseases;Virus Replication;West Nile;West Nile virus

PROJECT_TITLE: RNA internal 2’-O methylation in SARS-CoV-2

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Pediatric;Prevention;Primary Health Care

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Vision screening, a key public health tool to identify children at risk for vision problems (significant uncorrected refractive error, amblyopia, and strabismus) is currently mandated in 41 states; however, it is not known which currently used screening test(s) effectively identify at-risk school-age children in need of further eye care. Development of evidence-based school-age vision screening guidelines and policies requires much stronger data on the effectiveness of screening tests than are currently available. This planning grant helps lay the foundation for a future UG1 to perform a full-scale study with side-by-side comparisons between alternative screening tests to determine the best screening test(s) for identification of school-age children at risk for significant vision problems that are common in school-age children and may impede learning.

PI_NAMEs: CINER, ELISE B;COLLINS, MEGAN E;KULP, MARJEAN T (contact);YING, GUI-SHUANG

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: access disparities;Address;Adopted;Affect;Age;Amblyopia;Baltimore;Blindness;Caring;Case Manager;Certification;Child;Child Care;clinical center;community partners;compare effectiveness;cost;cost effectiveness;Cost Measures;Data;Data Analyses;Data Collection;data management;Development;Disparity population;economic cost;Effectiveness;elementary school;Enrollment;Ensure;Equity;Ethnic Origin;Evaluation;evidence base;experience;Eye;Eye diseases;Feasibility Studies;follow-up;Foundations;Future;Gender;Grant;Health Personnel;Health Services Accessibility;improved;instrument;Interview;Learning;Manuals;Measures;Methods;Minority Groups;Monitor;multidisciplinary;new technology;Nurses;ophthalmic examination;organizational structure;Parents;Participant;Population Heterogeneity;Procedures;protective factors;Protocols documentation;Public Health;Quality of life;Race;Reading;recruit;Refractive Errors;Reporting;Risk;Sample Size;School-Age Population;screening;screening guidelines;screening policy;Screening Result;Sensitivity and Specificity;Side;Site;Socioeconomic Status;Specificity;Statistical Data Interpretation;Strabismus;study population;Subgroup;success;teacher;Technology;Testing;Time;tool;Training;Use Effectiveness;Variant;Vision;Vision Screening;Visual;Visual Acuity

PROJECT_TITLE: Identification of School-age Eye conditions Evaluation (ISEE)

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (01)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE The microcirculation plays a critical role in organ homeostasis and disease pathogenesis, yet developing quantitative methods to assess organ-specific microcirculation remains an ongoing challenge. Our proposal establishes methods to identify and validate measures of the coronary microcirculation from clinical coronary angiography cine imaging data (2-dimensional x time imaging). This project is therefore relevant to the NIH's mission to address an unmet need by developing novel imaging methods to improve the diagnosis of microvascular diseases and accelerate research into this crucial and understudied area.

PI_NAMEs: GUERRATY, MARIE A (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Affect;Anatomic Models;Anatomy;Angiography;Area;Biological Markers;biomarker identification;biomarker selection;Blood flow;Blood Vessels;Cardiac;Cardiovascular system;Caring;Cerebrum;Clinical;clinical care;cohort;Computer Models;Coronary;Coronary Angiography;Coronary Arteriosclerosis;Coronary artery;cost;Data;Data Set;Dedications;deep learning;design;Diagnosis;Disease;heart imaging;Heterogeneity;Homeostasis;Hybrids;Image;Image Analysis;imaging biomarker;imaging modality;imaging study;improved;instrument;Intelligence;Investigation;Kidney;Lung;Magnetic Resonance Imaging;Manuals;Measurement;Measures;Metabolic Clearance Rate;meter;Methods;Microcirculation;Microvascular Dysfunction;Mission;Monitor;Myocardial;Myocardial Ischemia;Myocardial tissue;new technology;novel;novel imaging technology;Optics;Organ;Parameter Estimation;Pathogenesis;Patients;Perfusion;Peripheral;Phenotype;Play;Positron-Emission Tomography;Public Health;Research;Resolution;Role;Rubidium;Stenosis;Techniques;Testing;Texture;Three-Dimensional Imaging;Time;time use;Tissues;two-dimensional;United States National Institutes of Health;Variant;Visualization;X-Ray Computed Tomography

PROJECT_TITLE: Angiography-derived Imaging Biomarkers of the Coronary Microcirculation

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE In 2022, New Jersey became the first U.S. state to enact a law requiring sales of nicotine replacement therapy (NRT) in licensed tobacco retailers. The extent to which such a law could further reduce tobacco use, with a positive equity impact, is unknown and the proposed research seeks to examine compliance with the NRT law and its association with community demographics, sales of NRT using retailer scanner data, and engagement with NJ Quitline. Study results may inform public health and tobacco regulatory policies and enhance future longitudinal research.

PI_NAMEs: HRYWNA, MARIA  (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Address;Advocacy;Censuses;Characteristics;Cigarette;cohort;Communities;Data;Data Collection;demographics;density;design;Devices;Disparity;disparity reduction;Effectiveness;Enrollment;Environment;Equity;ethnic diversity;Ethnic Population;evidence base;FDA approved;Future;Geographic Distribution;Health;health disparity;health equity promotion;high risk;implementation evaluation;improved;Income;Intake;Intervention;Laws;Learning;Licensing;Location;Low income;Marketing;Massachusetts;Medical;Methods;Monitor;neighborhood disadvantage;Neighborhoods;New Jersey;Nicotine;nicotine replacement;novel;Oral;Outcome;Pharmaceutical Preparations;Pharmacy facility;Policies;population health;Population Heterogeneity;programs;Public Health;public policy on tobacco;quitline;racial diversity;racial population;Reduce health disparities;reduce tobacco use;Regression Analysis;Research;Research Proposals;response;Sales;Sampling;social disparities;socioeconomics;Statutes and Laws;therapy adherence;Tobacco;tobacco advertising;tobacco control;tobacco exposure;tobacco products;Tobacco use;Tobacco Use Cessation;tobacco-free;Traction;trend;US State;Visit;web site

PROJECT_TITLE: Evaluating a novel policy to increase access to nicotine replacement therapy in community retailers

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: Project Narrative The proposed research project is relevant to public health because we address a major gap in our understanding of the genetic basis of cancer initiation and progression in pediatric brain tumor patients. The proposed research is highly relevant to the NIH mission of improving health outcomes as the heritability of pathogenic germline variants will inform genetic counseling and discoveries of basic genetic mechanisms of tumor initiation and progression will lead to rational clinical interventions.

PI_NAMEs: DISKIN, SHARON  (contact);ROKITA, JO LYNNE

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: 19 year old;Address;American;Atlases;Automobile Driving;Biological;Biological Markers;Blood - brain barrier anatomy;BRAF gene;Brain;Brain Neoplasms;Cancer Etiology;Cancer Histology;cancer initiation;cancer predisposition;Central Nervous System Neoplasms;Cessation of life;chemotherapy;Child;Childhood;Childhood Brain Neoplasm;Childhood Glioma;Clinical;clinically actionable;cohort;comparison control;computational pipelines;Copy Number Polymorphism;Correlative Study;Data;data integration;data resource;design;Diagnosis;Disease;DNA;DNA Repair Gene;DNA Sequence;DNA Sequence Alteration;DNA sequencing;Epidemiology;Evaluation;Event;evidence base;Future;Gene Fusion;gene repair;Gene set enrichment analysis;Genes;Genetic;Genetic Counseling;genetic risk factor;Genetic study;genetic variant;Genomics;Germ Lines;Germ-Line Mutation;Glioma;Goals;Health;Heritability;Histology;improved;improved outcome;in silico;Inherited;inhibitor;insertion/deletion mutation;insight;Intervention;kinase inhibitor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;Medical Genetics;medical schools;MEKs;Mismatch Repair;Mission;Modeling;molecular targeted therapies;Mutation;novel;Oncogenic;Outcome;Parents;Pathogenicity;Pathway interactions;Patients;Pediatric Neoplasm;Predisposition;proband;Process;Protein Isoforms;Public Health;rare variant;Recurrence;Reporting;Research;Research Project Grants;risk prediction;risk stratification;RNA;RNA Sequences;Sampling;Single Nucleotide Polymorphism;Solid Neoplasm;Spinal Cord Neoplasms;Structural Congenital Anomalies;success;Survival Analysis;Susceptibility Gene;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Transcript;transcriptome sequencing;tumor;tumor DNA;tumor heterogeneity;tumor initiation;tumor progression;tumorigenesis;United States;United States National Institutes of Health;Variant;virulence gene

PROJECT_TITLE: Identification and characterization of genetic risk factors in pediatric brain tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BTC-H (02)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Dietary Supplements;Emerging Infectious Diseases;Infectious Diseases;Nutrition;Rare Diseases;Tuberculosis

PHR: Project narrative Tuberculosis, caused by Mycobacterium tuberculosis, remains one of leading causes of death from infectious diseases. This program studies the function and mechanism of type II mitochondrial arginase in mediating the expression of host innate and adaptive immunity in response to M. tuberculosis infection. The program will lead to the development of adjunct HDTs by dietary supplementation of arginine and/or ornithine to improve bacterial clearance and shorten the duration of antibiotic therapy.

PI_NAMEs: SHI, LANBO  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: adaptive immunity;Animal Model;Antibiotic Therapy;antimicrobial;Antimycobacterial Agents;ARG2 gene;arginase;Arginine;Biochemical Pathway;Bioenergetics;Biological Assay;Biology;Bone Marrow;Cause of Death;Cells;co-infection;Communicable Diseases;Cytosol;Data;Development;Diet therapy;Dietary Supplementation;Disease;efficacy evaluation;Enzymes;Epidemic;experience;Generations;Genes;HIV;Homeostasis;Hyperargininemia;hypoxia inducible factor 1;Immune;immune activation;Immune response;Immunity;Immunologics;improved;in vivo;Infection;Inflammasome;Inflammatory Response;interest;Knockout Mice;Knowledge;latent infection;Lung;Macrophage;Macrophage Activation;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial metabolism;Morbidity - disease rate;mortality;mouse model;Multiple drug resistant Mycobacteria Tuberculosis;Mus;Mycobacterium tuberculosis;Natural Immunity;NOS2A gene;novel;Ornithine;Outcome;pathogen;Pathogenesis;Pathway interactions;Play;prevent;Preventive;Production;programs;Property;Recovery;Repression;Research;Research Personnel;response;Role;Signal Pathway;Signal Transduction;Signaling Molecule;stable isotope;Stimulator of Interferon Genes;Supplementation;Testing;Therapeutic;transcriptome sequencing;transcriptomic profiling;transcriptomics;Treatment outcome;Tuberculosis;tuberculosis immunity;Up-Regulation;Warburg Effect;Work

PROJECT_TITLE: Type II arginase and tuberculosis pathogenesis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: MILWAUKEE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: Project Narrative This project aims to develop a microscopic nuclear imaging technique that can provide the 3D distribution of clinical radiotracers (instead of tritiated forms or analogs) in a thick, living biological specimen (instead of a fixed and sliced specimen). The proposed instrument will improve our understanding of how clinical radiotracers are distributed at cellular level in a living, multi-cellular organism, and thereby will help us to better interpret clinical nuclear imaging. It will also allow us to test and select new radiopharmaceuticals using patient-derived organoids for safe and effective therapy.

PI_NAMEs: SUNG, YONGJIN  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TITLE: Three-dimensional imaging of radiopharmaceutical distribution in multicellular organism at cellular resolution

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases;Malaria;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Asymptomatic malaria infections caused by the Plasmodium falciparum parasite, while not clinically apparent, have significant individual and public health consequences, including chronic anemia, susceptibility to bacterial infections, and maintenance of onward transmission by serving as parasite reservoirs. Such infections can also adversely impact cognitive performance in school-aged children, but the potential mechanisms by which this occurs has not been well-studied. This project will measure blood inflammatory biomarkers and cognitive performance in asymptomatic children naturally infected with P. falciparum before and after anti-malarial treatment to determine whether clearance of parasitemia leads to improvements in cognitive performance by reducing systemic inflammation.

PI_NAMEs: MCHENRY, MEGAN SONG;TRAN, TUAN MANH (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: 10 year old;9 year old;Academic achievement;Acute-Phase Proteins;Address;Africa South of the Sahara;age stratification;aged;Anemia;Anti-malarials;Area;Artemisinins;Attention;Bacteremia;Bacterial Infections;Biological Markers;biomarker performance;Blood;Brain;C-reactive protein;Cessation of life;Child;Chronic;Clinical;Cognition;Cognitive;cognitive performance;cognitive testing;Combined Modality Therapy;Communities;cytokine;Data;density;Development;Female;follow-up;Goals;Hemoglobin;Immunity;improved;Income;Individual;Infant;Infection;Inflammation;Inflammatory;inflammatory marker;Interleukin-1 beta;Interleukin-10;Interleukin-6;Intervention;Intervention Trial;Kenya;Knowledge;Legal patent;Life;Link;Maintenance;Malaria;malaria infection;malaria transmission;Measurable;Measures;Mediating;Microscopy;Morbidity - disease rate;mortality;Outcome;Parasitemia;Parasites;Pilot Projects;Plasma;Plasmodium falciparum;Predisposition;processing speed;Productivity;programs;Public Health;Random Allocation;randomized trial;Research;School-Age Population;Schools;Short-Term Memory;sustained attention;systemic inflammatory response;Testing;TNF gene;transmission process;treatment effect

PROJECT_TITLE: Assessing the Impact of Treatment of Asymptomatic Malaria Infections on Inflammation and Cognition in Schoolchildren

STUDY_SECTION: PRID

STUDY_SECTION_NAME: Population based Research in Infectious Disease Study Section[PRID]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: Project Narrative The stakes for determining whether the surprisingly resilient infant health advantage observed among U.S. Hispanics has been imperiled by the COVID-19 pandemic are high. Healthy birth outcomes set the stage for the health and well-being across the life course, with poor perinatal outcomes producing enduring effects in later life. If the Hispanic infant health advantage has indeed been threatened, then there are likely long- term consequences for inequality that urgently need to be documented in order to determine where to focus resources, not just at birth, but also at other stages of child development.

PI_NAMEs: FRANK, REANNE  (contact);WILDSMITH, ELIZABETH

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Accounting;Adult;Affect;Age;Agreement;Birth;burden of illness;California;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;Child Care;Child Development;Communities;Country;County;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Discrimination;Educational Status;Employment;Environment;Epidemiology;ethnic minority population;Ethnic Population;Exclusion;experience;Generations;geographic difference;Growth;Health;Heterogeneity;Hispanic;Hispanic Americans;Hispanic Populations;Hispanic Women;hospitalization rates;Income;Inequality;Infant;Infant Health;Infant Mortality;Intake;Label;late life;Latinx;Latinx population;Life Cycle Stages;Life Expectancy;Low Birth Weight Infant;maternal stress;Measures;model building;Modeling;mortality;Mothers;Not Hispanic or Latino;Nutritional;Occupations;older adult;Outcome;pandemic disease;pandemic impact;Pattern;perinatal outcomes;Personal Satisfaction;Persons;Play;Population;post-pandemic;Poverty;Predisposition;premature;Race;racial population;resilience;Resources;response;Risk;SARS-CoV-2 infection;Severe Acute Respiratory Syndrome;Shock;Small for Gestational Age Infant;socioeconomics;Source;Specific qualifier value;Subgroup;Terminology;Testing;Time;trend;Uterus;Variant;Vital Statistics;White Women

PROJECT_TITLE: The Impact of the COVID19 Pandemic on the Hispanic/Latinx Birth Outcome Advantage

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative There is no contemporary, nationwide data about how diabetes is managed among people with diabetes and end-stage kidney disease, and how this affects the risks of health-related outcomes (mortality, readmissions, hospitalizations) and severe hypoglycemia and hyperglycemia crises -common yet potentially preventable events in this high-risk population. This proposal will leverage expertise (secondary data analysis, health- outcomes research) of a multi-disciplinary research team and the most comprehensive nationwide database of patients with ESKD, the United States Renal Data System (USRDS), to characterize contemporary patterns of glucose-lowering therapy and diabetes technologies among patients with diabetes and ESKD; quantify rates of all-cause and cause-specific hospitalizations/emergency department visits (severe hypoglycemia and hyperglycemia), mortality, and readmissions, as a function of each glucose-lowering therapy. These results will have strong clinical and translational impact on the management of glycemia in the setting of ESKD and will be used to inform prospective trials to support safer treatments in this high-risk population.

PI_NAMEs: GALINDO, RODOLFO  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Address;Adult;adverse event risk;Affect;African American population;Age;aging population;Agonist;Amputation;analog;Anti-diabetic Drugs;Big Data;Blood capillaries;Bolus Infusion;Calibration;Cardiovascular Diseases;Cardiovascular system;Caring;Cessation of life;Clinical;Clinical Research;Clinical Trials;comorbidity;Complement;Complex;Continuous Glucose Monitor;Coupled;Data;Data Analyses;Databases;design;Devices;diabetes management;Diabetes Mellitus;Dialysis procedure;Disparity;Emergency department visit;End stage renal failure;Epidemiology;ethnic minority population;Ethnic Origin;Event;Exclusion;experience;Formulation;GLP-I receptor;Glucose;glucose metabolism;glycemic control;Grant;Half-Life;Health;high risk;high risk population;Hispanic Populations;hospital readmission;Hospitalization;Human;Hyperglycemia;Hypertension;Hypoglycemia;improved;Incidence;Information Systems;Infusion procedures;inhibitor;Insulin;Insulin Infusion Systems;insulin sensitivity;Interdisciplinary Study;Intramural Research;Kidney;Knowledge;Microvascular Dysfunction;Minority Groups;Monitor;mortality;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;Observational Study;older patient;Outcome;Outcomes Research;patient oriented;Patients;Pattern;Persons;Pharmaceutical Preparations;Pharmacoepidemiology;pharmacologic;Population;Positioning Attribute;Prevalence;prevent;programs;prospective;Prospective Studies;Pump;Race;racial minority population;randomized trial;randomized, clinical trials;readmission rates;Recommendation;Regimen;Renal clearance function;Reporting;Research Infrastructure;Retinal Diseases;Risk;Risk Reduction;Safety;Sampling;sensor;sex;standard of care;Standardization;subcutaneous;Subgroup;Sulfonylurea Compounds;System;Technology;Testing;Time;translational impact;Translational Research;Treatment Protocols;trend;United States;Work

PROJECT_TITLE: Pharmaco-epidemiology of diabetes in patients with end-stage kidney disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Chronic Pain;Complementary and Integrative Health;Endocannabinoid System Research;Multiple Sclerosis;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Therapeutic Cannabinoid Research

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Public Health Relevance Statement The therapeutic benefits of minor cannabinoids are largely unknown despite the legalization and increased use of cannabis by millions of Americans both medicinally and recreationally. Significant gaps exist in understanding the potential health benefits, risks, dosing, and pharmacology of this widespread and important class of natural products. Our expertise in cannabinoid biosynthesis and lipid receptor biology together with our discovery that the minor cannabinoid cannabichromene (CBC) targets the LPA receptor offer a path to evaluate the >100 natural minor cannabinoids for their unrealized therapeutic potential in chronic pain, obesity, and neurodegenerative diseases.

PI_NAMEs: CHUN, JEROLD ;MOORE, BRADLEY S (contact)

PROGRAM_OFFICER_NAME: STILL, PATRICK COLBY

PROJECT_TERMS: Address;American;Anabolism;analog;Animal Model;Animals;Bacteria;Binding;Biochemical;Bioinformatics;Biological;Biological Assay;Biology;blood-brain barrier crossing;cannabichromene;Cannabidiol;cannabigerol;cannabinoid receptor;cannabinoid treatment;Cannabinoids;Cannabis sativa plant;CB1 knockout;Cells;Chemicals;Chemistry;chronic pain;chronic pain management;CNR1 gene;Collaborations;Cyclization;Data;design;design,build,test;Development;Disease;Dose;Endocannabinoids;endogenous cannabinoid system;Engineering;Enzymes;Evaluation;Evolution;Experimental Autoimmune Encephalomyelitis;experimental study;Functional disorder;G-Protein-Coupled Receptors;Genetic;Health;Health Benefit;Human;in vivo;inorganic phosphate;insight;interest;Interferometry;Investigation;Joints;knockout animal;Knockout Mice;Laboratories;Lead;Learning;Legal;Libraries;Ligation;Link;Lipids;lysophosphatidic acid;Lysophosphatidic Acid Receptors;Lysophospholipid Receptors;Lysophospholipids;marijuana use;Medicine;Metabolic;Methods;microbial;Minor;Multiple Sclerosis;Mus;mutant;National Center for Complementary and Integrative Health;Natural Products;Nerve Degeneration;Neurodegenerative Disorders;novel;novel therapeutics;Obesity;painful neuropathy;Pathway interactions;pharmacologic;Pharmacology;Pharmacology Study;Phosphorylation;Physiological;Physiology;phytocannabinoid;Plants;Production;Property;public health relevance;receptor;Recreation;Regulation;Reporting;Research;Resources;response;Risk;Route;scaffold;sciatic nerve;screening;Signal Transduction;Structure;Structure-Activity Relationship;synergism;synthetic biology;System;Technology;Terpenes;Testing;Therapeutic;therapeutic development;vzg-1 Receptor;Work

PROJECT_TITLE: Biosynthesis and biological mechanism of minor cannabinoids

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Mental Health;Obesity;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE There is a high burden of cardiovascular disease (CVD) risk factors among contemporary adolescents, and current behavioral treatments for this age group are insufficient in terms of both efficacy and population reach. The proposed research will develop and pilot test novel intervention components targeting the core motivational mechanisms of emotion and identity to increase efficacy, and deliver them alongside standard behavioral content using protocolized, remote, and largely self-guided methods to increase scalability. This work represents the multiphase optimization strategy’s Preparation phase and will fully prepare us to conduct a large-scale Optimi- zation-phase factorial trial and assemble a lean, effective, and scalable intervention package for adolescents with CVD risk factors, which directly responds to calls from pediatric guidelines and the NHLBI.

PI_NAMEs: MARMA, AMANDA K (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: academic intervention;acceptability and feasibility;Adherence;Adolescence;Adolescent;Adolescent Behavior;Adult;Age;age group;Anxiety;arm;Attention;Behavior;behavior change;behavior change wheel;Behavior Therapy;Behavioral;behavioral study;Benchmarking;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Childhood;Clinical;Clinical Trials;community advisory board;comorbidity;cost;Data;Development;diabetes prevention program;Diagnostic;digital;Dimensions;Dose;effectiveness testing;efficacy trial;emotion regulation;Emotional;Emotional disorder;Emotions;empowerment;Enrollment;Equilibrium;Evaluation;Event;experience;Feeling hopeless;Foundations;Future;Goals;Guidelines;Health;Health behavior;Health Promotion;healthy lifestyle;Impairment;implementation design;improved;insight;interest;Intervention;intervention refinement;Interview;iterative design;Methods;mortality;Motivation;multiphase optimization strategy;National Heart, Lung, and Blood Institute;natives;Neurobiology;novel;Obesity;Obesity associated cardiovascular disease;person centered;Phase;pilot test;pilot trial;Population;preference;premature;Preparation;prevent;Preventive;Process;programs;Protocols documentation;prototype;Psychologist;psychosocial stressors;Randomized;Recommendation;recruit;Regulation;remote delivery;Research;response;Risk;Risk Factors;Self Perception;Societies;Structure;Target Populations;Teenagers;Testing;theories;Thinness;Work;Youth

PROJECT_TITLE: Developing a Novel Adolescent Cardiovascular Health Promotion Program (CPP)

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT (OA)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunization;Immunotherapy;Nanotechnology;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative  The proposed research is relevant to public health because it will lead to a clinical solution treating metastatic breast cancer, a disease that conventional approaches have failed to treat. Considering wide presence and great significance of purinergic signaling in various immune-related diseases, this project is expected to have broad translational importance in disease-specific immunotherapy.

PI_NAMEs: MING, XIN  (contact);TIAN, SHAOMIN

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adenosine;anti-cancer;antibody test;Antibody-drug conjugates;anticancer activity;Antitumor Response;Boronic Acids;Breast Cancer Cell;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer cell;cancer immunotherapy;Cells;Clinical;Combined Modality Therapy;Complement;Cytometry;Disease;Drug Delivery Systems;Drug Targeting;effective therapy;Enzyme Inhibitor Drugs;ERBB2 gene;extracellular;feasibility testing;Immune;immune activation;Immune Evasion;immunogenic;immunogenic cell death;Immunotherapeutic agent;Immunotherapy;inhibitor;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;mouse model;Mus;nanoparticle;nanotherapy;Normal tissue morphology;novel;Nucleosides;nucleotide analog;Nucleotides;Patients;PD-1 blockade;Pharmaceutical Preparations;Play;prevent;Public Health;recruit;Research;response;Signal Transduction;Site;System;Testing;Translating;Trastuzumab;tumor;Tumor Immunity;tumor microenvironment

PROJECT_TITLE: ATP-responsive Nanoparticles for Reversal of Immune Evasion in Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 TIR-W (01)]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLLEGE PARK

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative The present study applies a social-vulnerability theoretical approach to understanding family-household structure, housing condition changes, and household moves as mechanisms associated with elderly disability and chronic morbidity acquisition under extreme coastal flooding events in India. This will contribute to substantive and theoretical understanding of elder health vulnerabilities to climate change more generally, including to coastal cylones/hurricanes, and to riverine and flash flooding, all of which are forecasted to increase in frequency and severity in South Asia and globally.

PI_NAMEs: RENDALL, MICHAEL S. (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Acquired disability;Age;Age disparity;aged;Asia;Attention;Bangladesh;Characteristics;Child;Chronic;Cities;Climate;climate change;climate-related health;comparison group;Country;Data;Data Collection;design;Development;disability;Disasters;Disparity;Economics;Elderly;Event;experience;Exposure to;Family;Family member;field survey;Floods;Frequencies;Future;Geriatric Assessment;Grant;Health;Household;Household and Family;Housing;Housing for the Elderly;Human;Human Development;Hurricane;Income;India;Individual;Living Arrangement;Location;low and middle-income countries;member;Methodology;Morbidity - disease rate;Natural Disasters;Neighborhoods;Older Population;Outcome;Personal Satisfaction;Population;population health;Rain;Recording of previous events;Research;Residential Mobility;Risk;Sampling;sea level rise;Severities;Slum;social;social determinants;social vulnerability;sociodemographics;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;Structure;Surveys;Time;urban area

PROJECT_TITLE: Acquisition of disability and chronic morbidity by older Indians following extreme urban coastal flooding events

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Substance Misuse

ORG_DEPT: NUTRITION

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE People that experience prenatal alcohol exposure are at higher risk for risky alcohol drinking as adolescents or young adults. Prenatal or adolescent exposures can independently result in cognitive and behavioral deficits that are driven, in part, by changes in specific cell populations and/or alcohol-induced (neuro)inflammation. The aim of this grant is to develop rat and mouse models to determine whether the “double-hit” of prenatal + adolescent exposure is additive, synergistic, or non-combinatorial.

PI_NAMEs: MOONEY, SANDRA M (contact);ROBINSON, DONITA L

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Acetylcholine;Adolescence;Adolescent;adolescent alcohol exposure;Adult;Alcohol consumption;alcohol exposure;alcohol research;alcohol use disorder;Alcohols;Animal Model;Animals;Astrocytes;Attention;basal forebrain;basal forebrain cholinergic neurons;Behavior;behavior test;Behavioral;Biological Assay;Birth;Brain;Cells;cholinergic;cholinergic neuron;Cognition;Cognitive;Cognitive deficits;Control Animal;Data;Development;drinking;Ethanol;experience;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetus;flexibility;Genes;Gliosis;Grant;Health;high risk;Hippocampus;Human;human model;Hypersensitivity;Individual;Inflammation;Inflammatory;Intervention;Investigation;Learning;Life;life span;Literature;maltodextrin;mature animal;Measures;Microglia;Modeling;Morphology;mouse model;Mouse Strains;Mus;neurochemistry;neuroinflammation;Neurons;novel;Oral;Outcome;Persons;Phenotype;Population;postnatal;preadolescence;Prefrontal Cortex;Pregnancy;pregnant;Pregnant Women;prenatal;prenatal experience;prenatal risk factor;Rat Strains;Rattus;Regimen;Reporting;Research Personnel;Reversal Learning;Risk;Risk Factors;Rodent;Rodent Model;Role;Signal Transduction;Students;Testing;therapeutic target;twelfth grade;underage drinking;Water;young adult

PROJECT_TITLE: Modeling alcohol exposure in gestation and adolescence

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-M (02)]


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The overall goal of this project is to identify human genes that are important for infection by pathogenic viruses that cause human disease such as Coxsackievirus, poliovirus, and noroviruses. To achieve this, we will first study virus infection in a simple model organism, the nematode C. elegans, and determine whether related genes function similarly in human cells.

PI_NAMEs: WANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;antiviral drug development;Area;Astroviridae;Astrovirus;Biological;Biological Assay;Biology;Caenorhabditis elegans;Candidate Disease Gene;Caspase;Cell Culture Techniques;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Coxsackie Viruses;CRISPR screen;Defense Mechanisms;Double-Stranded RNA;Encephalomyocarditis virus;Family;gene conservation;Gene Deletion;gene function;Genes;Genetic;Goals;Growth;Human;human disease;human pathogen;Human poliovirus;Immune;in vivo;Infection;influenzavirus;Integration Host Factors;interest;knock-down;Knock-out;knockout animal;Knockout Mice;Knowledge;Link;lipid metabolism;Mammalian Cell;Mammals;Messenger RNA;Microbe;model organism;Modeling;Mus;Mutagenesis;Nematoda;Norovirus;novel;novel strategies;obligate intracellular parasite;Orthologous Gene;pathogenic virus;Pathogenicity;Pathway interactions;Phenotype;Play;Poliomyelitis;Process;Proliferating;Publications;Publishing;Research;Rhinovirus;RNA amplification;RNA Interference;RNA interference screen;RNA Viruses;RNA-Directed RNA Polymerase;Role;screening;Signal Pathway;Signal Transduction;Small Interfering RNA;Survival Rate;Testing;Toll-like receptors;tool;Transferase;Uridine;Viral;Viral Physiology;viral RNA;virology;Virus;Virus Diseases

PROJECT_TITLE: Identification of evolutionarily conserved pro-viral and anti-viral host factors from worms to mammals

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Patient Safety;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Constructing a comprehensive sociotechnical framework for risk stratification is key to improving health equity in care delivery, addressing the disproportionate impact of congestive heart failure on African Americans. The project will create nurse-led care models that decrease hospitalizations and advance the role of nursing in stratifying hospitalization risk.

PI_NAMEs: WILLIAMS, TREMAINE  (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Adult;Affect;African American;African American population;American;Arkansas;Attitude;Behavioral;Belief;Cardiovascular Diseases;care delivery;care outcomes;Caring;Caucasians;Cause of Death;Charge;Clinical;clinical data repository;clinical investigation;Code;Communicable Diseases;computerized tools;Congestive Heart Failure;County;Critical Care;Data;Death Rate;Diagnosis;Diet;Disease Outbreaks;Disparity;Equilibrium;Equity;evidence base;evidence based guidelines;Exclusion;Expenditure;follow-up;Gender;Genomics;Glucose;Guidelines;health disparity;health equity;Health system;Heart Diseases;High Prevalence;hospital readmission;Hospitalization;Hospitals;improved;indexing;innovation;Interview;Linear Regressions;Lipids;member;men;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Needs Assessment;Nurse's Role;Nurses;Occupations;Outcome;Pathway Analysis;Patient Care;patient population;patient stratification;Patients;Perception;Persons;Physical activity;Physiological;Prevalence;Preventive care;Process;Quality of Care;Race;racial population;Random Allocation;Registered nurse;Research;Resources;Risk;Risk Factors;risk stratification;Role;routine care;Rural;rurality;Sampling;Service delivery model;Smoking;Social Network;statistics;Structure;Subgroup;success;Surveys;System;task analysis;Testing;Time;tool;Training;Underrepresented Populations;United States;urgent care;usability;Variant;Woman

PROJECT_TITLE: Equitable Standards of Care Delivery in Team-based Risk Stratification of African Americans with Congestive Heart Failure

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Contraception/Reproduction;Dementia;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Neurodegenerative;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_DEPT: SURGERY

PHR: Narrative Women exposed to preeclampsia are more likely to develop cardiovascular and cerebrovascular syndromes later in life. The proposed studies will establish apelin receptor axis as novel neuroprotective pathway counteracting long-term cerebrovascular syndrome in preeclampsia.

PI_NAMEs: YAMALEYEVA, LILIYA M (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Affect;Anti-Anxiety Agents;Anti-Hypertensive Agents;Antiinflammatory Effect;Anxiety;anxiety-like behavior;apelin-13;APLN gene;Area;arterial stiffness;Blood - brain barrier anatomy;Blood flow;blood pressure reduction;Brain;Brain Edema;brain parenchyma;Cardiovascular system;Cells;Cerebral endothelium;Cerebral Ischemia;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chorionic villi;Circulation;Clinical;Cognition;Cognition Disorders;Cognitive;cognitive change;cognitive function;Data;Development;Disease;endoplasmic reticulum stress;endothelial dysfunction;Event;excitotoxicity;experience;Exposure to;Functional disorder;Future;Heterogeneity;Hypertension;hypertensive;Hypoxia;Impaired cognition;Impairment;improved;Inflammation;Inflammation Mediators;Infusion procedures;Interleukin-6;Investigation;Ischemia;Laboratories;Life;Link;Literature;Mental Health;Messenger RNA;middle cerebral artery;Modeling;Mus;neuroinflammation;Neurons;neuroprotection;novel;novel therapeutics;Outcome;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathway interactions;Patients;Pattern;Perfusion;Peripheral;Placenta;post pregnancy;Pre-Eclampsia;Pregnancy;pregnancy disorder;prevent;Preventive;Process;protective pathway;Proteins;Proteinuria;psychologic;Publishing;Quality of life;Rattus;receptor;Recording of previous events;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;response;Role;Signal Transduction;Sleep disturbances;sleep pattern;Stress;Stroke;Syncytiotrophoblast;Syndrome;System;Testing;Therapeutic;therapeutic target;therapy development;Time;trend;Vascular Dementia;White Matter Hyperintensity;Woman

PROJECT_TITLE: Apelin receptor axis and long-term consequences of preeclampsia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rehabilitation;Women's Health Research

PHR: PROJECT NARRATIVE Breast reconstruction is a critical component of breast cancer treatment because it restores quality of life and body image after mastectomy. However, Spanish-speaking Latina breast cancer survivors experience high dissatisfaction and regret about their breast reconstruction decisions. This research will culturally and linguistically adapt a proven decision aid called BREASTChoice for Spanish-speaking Latina breast cancer survivors.

PI_NAMEs: LEE, CLARA NAN-HI (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Acculturation;Body Image;Breast Cancer survivor;Breast Cancer Treatment;cancer care;Cancer Survivor;cancer therapy;care delivery;Communities;community organizations;community partners;Complication;Decision Aid;design;Diagnosis;Dissemination and Implementation;Effectiveness;Evaluation;experience;Feedback;Friends;Future;Growth;Guidelines;Health;high risk;Hispanic Populations;Home;improved;indexing;Infection;informant;Insurance Coverage;Intervention;Interview;Knowledge;Language;Latin American;Latina;Latina Population;Latino Population;Latinx;Latinx population;Laws;Linguistics;Malignant Breast Neoplasm;Malignant Neoplasms;Mammaplasty;Mastectomy;Methods;Minority Groups;Mission;online community;Outcome;Participant;Patients;Persons;Population;portability;Positioning Attribute;preference;Process;Quality of life;Randomized, Controlled Trials;reconstruction;Regrets;Research;response;Risk;risk prediction model;Sampling;shared decision making;social media;Spanish;Spanish/English;Surgeon;Surveys;Survivors;System;Target Populations;Testing;Time;tool;Translating;usability;web site;Woman;wound;Writing

PROJECT_TITLE: Cultural and Linguistic Adaptation of a Breast Reconstruction Decision Tool

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (O2)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

PHR: PROJECT NARRATIVE Age-related macular degeneration (AMD) is the most common cause of severe loss of eyesight in the elderly population. Retinal pigment epithelium degeneration is a hallmark of AMD disease progression, and despite current efforts, no established treatments are available. We will develop a novel treatment using AMD patients’ own urine-derived stem cells to generate new retinal pigment epithelial cells to restore AMD patients’ vision.

PI_NAMEs: ZHANG, YUANYUAN NO (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Address;Adherence;Adherent Culture;Adult;Age related macular degeneration;Allogenic;Animal Model;Animals;Archives;Autologous;Biological Assay;Biopsy;Blood;Blood Cells;Bone Marrow Cells;c-myc Genes;Cardiac Myocytes;Cell Line;Cell Lineage;Cell Proliferation;Cell Therapy;Cells;clinical application;cost;cost effective;cost effectiveness;differentiation in vitro;disease model;Disease Progression;drug discovery;Dryness;Elderly;Electrical Resistance;Epithelial Cells;epithelial stem cell;Epithelium;Ethics;Eye diseases;Fibroblasts;Future;Gene Expression;Generations;Goals;Human;human adult stem cell;human embryonic stem cell;Immune;immunogenicity;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Kidney;Kinetics;matrigel;Medical;Mesenchymal Stem Cells;Methods;Mononuclear;Morphology;Natural regeneration;neural;Neurons;Nose;novel;novel strategies;novel therapeutics;Outcome;Patients;peripheral blood;personalized medicine;Phase;Phenotype;Photoreceptors;Pigmentation physiologic function;Pluripotent Stem Cells;Population;precision drugs;prevent;progenitor;programs;Property;Protocols documentation;Regenerative capacity;Research;Retina;retina implantation;Retinal Degeneration;retinal toxicity;retinol isomerase;RPE65 protein;sight restoration;Skin;Somatic Cell;Source;stem cell biomarkers;stem cell therapy;stem cells;Structure of retinal pigment epithelium;Suspension Culture;Telomerase;Testing;Therapeutic;Tight Junctions;tissue regeneration;tissue repair;Tissues;Toxicity Tests;transcription factor;transcriptome;Urine;Validation;Vision;visual cycle;Visual impairment

PROJECT_TITLE: Regeneration of human RPE cells from autologous urine-derived iPS cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]