NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Disease

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative HIV co-infection accelerates liver cirrhosis and liver cancer in chronic hepatitis B virus (HBV) carriers. The use of primary cell culture models together with unbiased and targeted functional genomics and proteomics approaches will determine host proteins that are induced or suppressed under co-infection conditions and in response to antiviral treatment. These studies will provide information for developing novel antiviral strategies that may lead to a functional HBV cure.

PI_NAMEs: MICHAILIDIS, ELEFTHERIOS  (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: Acceleration;Affect;Aftercare;analytical method;Anti-Inflammatory Agents;Anti-viral Agents;Area;Atlases;Biological;Capsid;CD4 Positive T Lymphocytes;Cell Culture Techniques;cell type;Cells;Chronic;Chronic Hepatitis B;Circular DNA;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;Coculture Techniques;CRISPR screen;CRISPR/Cas technology;cytokine;Dependence;Development;Environment;Family;functional genomics;Genes;global health;Goals;HBV Liver Cancer;Hepatitis B Infection;Hepatitis B Virus;Hepatocyte;high risk;HIV;HIV Infections;Human;humanized mouse;Immune response;Immunologic Adjuvants;In Vitro;in vivo;Individual;Infection;inhibitor;innate immune mechanisms;innate immune pathways;innovation;insight;Integration Host Factors;Interferon alpha;Interferon Type I;Interferons;Investigation;Knock-out;Knowledge;Kupffer Cells;Life Cycle Stages;Link;Liver;Liver Cirrhosis;Liver diseases;Maintenance;Malignant neoplasm of liver;Methods;Modeling;Molecular;multiple omics;Natural Immunity;novel;novel therapeutic intervention;Nuclear;nucleoside analog;Pathogenesis;Pathology;Pathway interactions;Persons;phosphoproteomics;Primary carcinoma of the liver cells;Primary Cell Cultures;protein expression;Proteins;Proteome;Proteomics;response;Risk;Role;Series;System;targeted treatment;Therapeutic;therapy design;Time;tool;transcriptome;transcriptomics;Validation;Viral;Viral Genome;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases;Virus Inhibitors;Virus Replication

PROJECT_TITLE: A proteomics atlas of HIV/HBV infections for curing HBV

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Although people living with HIV (PLWH) are at greater risk of developing active TB disease and more likely to suffer poor treatment outcomes compared to individuals not living with HIV, currently available diagnostic tools perform poorly among PLWH. The objective of this proposed study is to determine both the analytical performance of a prototype Mycobacteria tuberculosis antigen detection assay in plasma and its clinical performance among PLWH using previously collected and well characterized clinical samples. By leveraging advancements in nanotechnologies this novel diagnostic protype has the potential to fundamentally change the TB diagnostic landscape for PLWH.

PI_NAMEs: SEIFERT, MARVA  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, KAREN A

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;analytical method;antigen detection;Antigen Targeting;antigen test;Antigens;Bacteria;bioelectronics;Biological;Biological Assay;Blinded;Blood;Body Fluids;Cause of Death;Cessation of life;Chemistry;Clinic;Clinical;Clinical Trials;Complex;cost;COVID-19;cross reactivity;Data;Decentralization;design;Detection;detection assay;Development;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic tool;diagnostic value;Disease;Engineering;Enzymes;experimental study;fabrication;Filtration;follow-up;Funding;General Population;Global Change;Goals;HIV;HIV Infections;Immunocompetent;improved;Individual;innovation;instrumentation;Laboratories;Lung;Lung Diseases;Methods;Microscopy;Miniaturization;mortality;mortality risk;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Nanotechnology;non-tuberculosis mycobacteria;novel;novel diagnostics;Nucleic Acid Amplification Tests;Participant;Pathogenesis;patient population;Patients;Performance;Persons;Plasma;point of care;point-of-care diagnostics;Population;portability;Prevalence;Proteins;Protocols documentation;prototype;Rapid diagnostics;Reference Standards;Resource-limited setting;Risk;Sampling;Sensitivity and Specificity;Series;Serum;Severity of illness;Specificity;Specimen;Sputum;Standardization;success;Technology;Testing;transmission process;Treatment outcome;treatment response;Tuberculosis;tuberculosis diagnostics;Urine;validation studies

PROJECT_TITLE: Detecting active tuberculosis disease: a blood-based Mycobacterium tuberculosis antigen detection asssay


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: RICHMOND

ORG_DEPT: PHARMACOLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Opioid use disorder (OUD) worsens the effects of HIV in the nervous system and this project will systematically study opioid and non-opioid actions of fentanyl, as well as the life-threatening combination of fentanyl and xylazine (“tranq”) in an animal model of neuroHIV. This project will determine why the morbidity and mortality of fentanyl is far worse than other opioids and how fentanyl uniquely exacerbates the neuroinflammatory and neurodegenerative consequences of HIV in the brain. This project also will identify novel fentanyl-specific therapeutic targets to treat the neurological and neurocognitive consequences of OUD and HIV infection.

PI_NAMEs: HAUSER, KURT F (contact);YAROTSKYY, VIKTOR

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Action Potentials;Acute;Adrenergic Agents;Adrenergic Agonists;Affect;Agonist;analog;Animal Model;Astrocytes;beta-adrenergic receptor;Blood - brain barrier anatomy;Brain;Cells;Cessation of life;chemokine;Chest wall structure;Coculture Techniques;comorbidity;Complex;Confocal Microscopy;Consequences of HIV;Corpus striatum structure;Data;Dopamine D1 Receptor;Drug Combinations;Electrophysiology (science);excitotoxicity;Fentanyl;Heroin;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;Immunosuppression;In Vitro;in vivo;Induced pluripotent stem cell derived neurons;Inflammation;Inflammation Mediators;Inflammatory;Injury;insight;Laryngismus;Life;Mediating;Microglia;Modeling;Molecular;Morbidity - disease rate;Morphine;mortality;Mus;Muscle Rigidity;Naloxone;Nerve Degeneration;Nervous System;neuroAIDS;Neurocognitive;Neuroglia;Neuroimmune;neuroinflammation;Neurologic;Neuronal Dysfunction;Neuronal Injury;Neurons;neurophysiology;non-opioid analgesic;novel;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;opioid use disorder;overdose death;Oxycodone;patch clamp;Pathologic;Perforation;Peripheral;Pharmaceutical Preparations;Physiological;Play;receptor;Refractory;Role;Slice;Structure;synthetic opioid;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;Transgenic Mice;United States;Virion;Wooden Chest Syndrome;Xylazine

PROJECT_TITLE: Opioid and non-opioid receptor mechanisms in neurons and glia underlying fentanyl and HIV comorbidity in the striatum

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Maternal Health;Orphan Drug;Pediatric;Pregnancy;Rare Diseases;Tuberculosis;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Pregnant people with TB have a high risk of adverse outcomes including miscarriage, preterm birth, and increased risk of maternal to child TB and HIV transmission; however, they are denied access to the most effective, most acceptable regimens. The Radiant-Moms study will utilize a mixed-methods design to assess relative priorities and trade-offs among pregnant and breastfeeding people, healthcare providers, policy makers, and community influencers regarding novel shorter TB treatment regimens during the pregnancy and postpartum periods. Radiant-Moms will provide a model for the earlier and appropriate inclusion of pregnant and breastfeeding people in TB clinical trials.

PI_NAMEs: HIRSCH-MOVERMAN, YAEL R (contact)

PROGRAM_OFFICER_NAME: LOMBO RODRIGUEZ, TANIA

PROJECT_TERMS: Acceleration;acceptability and feasibility;acquired drug resistance;Adherence;Adolescent;Adoption;Adult;adverse outcome;Africa;Age;AIDS clinical trial group;appropriate dose;Asia;Attitude;Breast Feeding;Caring;Characteristics;Child;child bearing;Clinical Trials;cohort;Communities;Consensus;Country;Data;design;Disease;Dose;Drug Kinetics;Drug resistance in tuberculosis;effective therapy;efficacy outcomes;Ethambutol;Evaluation;Exclusion;experience;experimental study;Fetal Development;Funding;Future;future implementation;Geography;Goals;Guidelines;Health Personnel;Health system;high risk;high risk population;HIV;HIV/TB;Human Resources;improved;Incidence;Infant;infant outcome;informant;International Maternal Pediatric Adolescent AIDS Clinical Trials;Interview;isoniazid;Knowledge;Life;maternal risk;Methods;Modeling;mortality risk;Moxifloxacin;novel;novel therapeutics;Participant;Perception;Persons;Pharmaceutical Preparations;Phase;Philippines;Policy Maker;post pregnancy;Postpartum Period;pragmatic implementation;Predisposition;preference;Pregnancy;Pregnancy Outcome;pregnant;Premature Birth;Prevalence;Prevention;programs;Publishing;Pyrazinamide;Qualitative Methods;Recommendation;Recording of previous events;Regimen;reproductive;Rifampin;rifapentine;Risk;Role;Safety;safety outcomes;Sampling;satisfaction;service delivery;Service delivery model;Services;side effect;social stigma;sociodemographics;South Africa;Spontaneous abortion;stakeholder perspectives;standard of care;Structure;Survey Methodology;Surveys;Target Populations;Time;Toxic effect;transmission process;treatment choice;treatment guidelines;Treatment outcome;Treatment Protocols;treatment services;Tuberculosis;tuberculosis treatment;United States;Update;willingness

PROJECT_TITLE: Rifapentine in High Doses in Pregnancy with TB (Radiant-Moms) study

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: AMHERST

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE The HIV-1/AIDS pandemic is an on-going global health crisis and while current therapies are effective, they have long term side effects that result in the need for improved therapies. Our work is focused on understanding the interplay between the host and HIV-1 with a focus on host restriction factors, proteins encoded by the host that are part of the cell intrinsic immune response. The proposed work focuses on determining the mechanism by which the membrane associated RING-CH proteins (MARCH proteins) utilize to restrict HIV-1 infection, which has the potential in assisting in the development of novel targets for new therapeutic avenues targeting HIV-1.

PI_NAMEs: D'ANGELO, MARY ROSE (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Anti-Retroviral Agents;antiretroviral therapy;Biological Assay;CD4 Positive T Lymphocytes;Cell membrane;Cell surface;Cell Survival;Cells;Charge;Co-Immunoprecipitations;Cytoplasmic Tail;Data;Development;Disease Progression;Down-Regulation;Enzyme-Linked Immunosorbent Assay;experimental study;Family;Family member;Genes;Genetic Transcription;global health;Glycoproteins;Goals;HIV-1;Homeostasis;Homo;Human;Humanities;Immune response;Immune system;Immune Targeting;Immunoblot Analysis;Immunofluorescence Immunologic;Immunologic Receptors;immunoregulation;improved;Infection;Infection Control;insight;Intercellular adhesion molecule 1;Invaded;knock-down;Length;Life Cycle Stages;Macrophage;Mediating;member;Membrane;membrane activity;Modeling;monocyte;mutant;new therapeutic target;novel;novel therapeutics;opportunistic pathogen;overexpression;pandemic disease;particle;pathogen;Patients;Physiological;Production;Protein Family;Protein Isoforms;Proteins;receptor;Receptor Cell;Reporting;Retroviridae Infections;Reverse Transcriptase Polymerase Chain Reaction;RNA Splicing;Role;side effect;small hairpin RNA;Structural Protein;T-Lymphocyte;Techniques;therapeutic development;trans-Golgi Network;Translations;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;Viral;Viral Physiology;Virion;Virus;Virus Diseases;Virus Replication;Western Blotting;Work

PROJECT_TITLE: Understanding the Antiviral Mechanism of MARCH9

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-G (20)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: In Malaysia, the high HIV prevalence among men who have sex with men (MSM) is exacerbated by significant stigma, hindering effective HIV prevention and treatment. This research proposal explores the implementation of rapid-start antiretroviral therapy (RS-ART) to reduce stigma and improve treatment outcomes for MSM. The study will employ asynchronous online focus groups and facilitate process improvement with clinical staff using NIATx quality improvement to assess RS-ART's effectiveness as a stigma reduction intervention, with dyadic analysis conducted to gain skills for a future K01.

PI_NAMEs: BROMBERG, DANIEL J (contact)

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acceleration;Address;Adherence;Affect;AIDS prevention;antiretroviral therapy;Applications Grants;Architecture;Behavior;Behavioral;behavioral economics;Behavioral trial;Biometry;Capital;career;Caring;Charge;Clinic;Clinical;Cohort Studies;cost;Country;Death Rate;Decision Making;design;Development;Diagnosis;Discrimination;Education;effective intervention;Effectiveness;Engineering;Epidemic;Evidence based practice;experience;Exploration, Preparation, Implementation, and Sustainment;Fellowship;Focus Groups;Future;Goals;Guidelines;hands on research;Health;health care settings;health disparity;Health Personnel;HIV;Homosexuality;humiliation;implementation barriers;implementation facilitation;implementation science;implementation strategy;improved;Incidence;Individual;Infection;Injecting drug user;innovation;insight;International Agencies;Intervention;Judgment;Laws;Learning;lens;low and middle-income countries;Low income;Malaysia;marginalized community;marginalized population;Medical;medical specialties;Medical Students;member;men who have sex with men;Mentors;Mentorship;mortality;multidisciplinary;Multinational Perspectives;Neurosciences;Newly Diagnosed;Opportunistic Infections;Outcome;pandemic disease;Patients;Persons;Phase;Physicians;Police;Policies;Politics;Population;Positioning Attribute;post-doctoral training;Prevalence;Prevention strategy;primary care clinic;Process;process improvement;programs;prospective;Protocols documentation;Psychology;Public Health;Public Policy;Recommendation;Research;Research Personnel;Research Proposals;Risk;Role;Sexual Transmission;skills;skills training;Social Marketing;social stigma;sodomy;Stereotyping;systematic review;Techniques;Testing;therapy design;tool;Training;Training Programs;treatment as prevention;Treatment outcome;treatment strategy;Viral

PROJECT_TITLE: Training in Behavioral Design Interventions to Address Stigma among Men Who have Sex with Men

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17B-K (20)]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: People with HIV are at increased risk of chronic kidney disease, which is mediated in part by genetic variants in the gene APOL1. We have identified a novel genetic variant of Ubiquitin D, which increases APOL1-mediated kidney injury. We therefore will perform innovative studies using novel human kidney cell models to determine how Ubiquitin D variants increase APOL1 toxicity, with the goal of improving the care of people with HIV.

PI_NAMEs: ROSS, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: NIHALANI, DEEPAK

PROJECT_TERMS: Address;African American population;African ancestry;AIDS-Associated Nephropathy;Alleles;antiretroviral therapy;APOL1 gene;Apolipoproteins;Apoptosis;Black Populations;Caring;Cell Cycle;Cell Death;cell injury;Cell model;Cells;Chronic Kidney Failure;Data;Development;Disease;Epithelial Cells;European;Gene Frequency;Genes;Genetic;Genetic Polymorphism;genetic variant;genomic locus;Genotype;glomerular function;Goals;Haplotypes;high risk;HIV;HIV Infections;Human;immune activation;Impairment;improved;In Vitro;in vitro Assay;Inflammation;Inflammatory Response;Injury;Injury to Kidney;innovation;insight;Interferons;kidney cell;Kidney Diseases;kidney epithelial cell;Laboratories;life span;Mass Spectrum Analysis;Measures;Mediating;Missense Mutation;Mitochondria;mortality;mortality risk;Mus;Necrosis;novel;novel strategies;Outcome;Pathogenesis;Pathway interactions;Persons;podocyte;Population;Predisposition;Prevalence;prevent;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Reporting;Resistance;response;response to injury;Risk;risk variant;Role;SARS-CoV-2 exposure;success;synergism;Testing;Toxic effect;Trypanosoma;UBD protein;Ubiquitin Like Proteins;Ubiquitination;Variant;Virus Diseases

PROJECT_TITLE: Effect of Ubiquitin D variants upon APOL1-mediated kidney injury

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Cost Effectiveness Research;Dietary Supplements;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Nutrition;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative For PLWH who are hospitalized in low- and middle-income countries, mortality during the subsequent 6 months after discharge ranges from 17-26% and likely accounts for over half off all HIV-associated mortality. We conducted a small pilot randomized trial of a structured medical, psychosocial counseling, and nutritional support home care intervention in South Africa and observed a 60% reduction in posthospitalization mortality (7.3% versus 18%). We are seeking to inform scale-up through a randomized trial to test our pilot findings, compare the home visit intervention with or without food, identify the underlying mechanisms of change, describe key implementation outcomes, and measure cost-effectiveness.

PI_NAMEs: HOFFMANN, CHRISTOPHER J (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: acute care;Address;Adherence;Admission activity;Adult;Africa South of the Sahara;age group;antiretroviral therapy;Area;arm;Behavioral Model;care outcomes;Caring;Cause of Death;Cessation of life;Client;Clinical assessments;Clinical Management;Clinical Nurse Specialists;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Cost Measures;cost-effectiveness ratio;Counseling;Diagnosis;Disclosure;Disease;Documentation;economic impact;effective intervention;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;effectiveness/implementation study;Elements;epidemic response;Facilities and Administrative Costs;Failure;follow-up;Food;food insecurity;food security;Future;Goals;Health;health service use;Health system;Healthcare;Heterogeneity;HIV;Home visitation;hospital bed;hospital readmission;Hospitalization;Hospitals;Household;Illness impact;implementation cost;implementation evaluation;implementation outcomes;improved;improved outcome;Income;incremental cost;incremental cost-effectiveness;Individual;innovation;Intervention;intervention delivery;intervention refinement;Interview;Knowledge;Literature;low and middle-income countries;Macronutrients Nutrition;Measures;Mediating;Medical;Medical Care Costs;medication compliance;member;microcosting;mortality;motivational enhancement therapy;nutritional supplementation;Nutritional Support;Participant;patient home care;Patients;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Policies;Policy Maker;Population;productivity loss;Professional counselor;prospective;psychosocial;Public Health;Quality of life;Quality-Adjusted Life Years;Randomized;randomized trial;randomized, clinical trials;Records;recruit;Reproducibility;Resources;Sampling;scale up;secondary outcome;sex;Social support;South Africa;South African;Standardization;Structure;Subgroup;Surveys;Target Populations;Testing;Time;tool;treatment as usual;treatment planning;trend;Triage;Trust;United States National Institutes of Health;Viral;Viral Load result;Visit;ward

PROJECT_TITLE: HomeLink2: Reducing posthospitalization mortality among people living with HIV through structured home care and nutritional supplementation


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases;Tuberculosis

PHR: PROJECT NARRATIVE Tuberculosis (TB) is the leading infectious cause of death worldwide, including among persons living with HIV. Peers with a history of TB or TB-HIV offer an untapped source of knowledge and social support to help persons with TB and TB-HIV better adhere to HIV and/or TB medications. This cluster-randomized trial in Uganda will evaluate the effectiveness and implementation of a novel, peer-led TB education and counseling strategy to improve outcomes among persons with TB with and without HIV and determine if and how social and behavioral factors like knowledge, social support, stigma, and self-confidence affect treatment outcomes.

PI_NAMEs: DAVIS, JOHN LUCIAN (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adolescent;Adoption;Adult;Affect;Africa South of the Sahara;antiretroviral therapy;arm;behavior change;behavior change wheel;Behavioral;Behavioral Mechanisms;Caring;Cause of Death;Client;Clinic;Clinical;Cluster randomized trial;Communities;Consolidated Framework for Implementation Research;contextual factors;cost effectiveness;Counseling;Data;design;Education;effective therapy;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Evaluation;evidence base;Evidence based intervention;Focus Groups;Future;Guidelines;Health Personnel;Health system;HIV;HIV/TB;Hybrids;implementation context;implementation evaluation;implementation fidelity;implementation outcomes;implementation research;improved;improved outcome;Individual;Intercept;interest;Intervention;Interview;Knowledge;literacy;Lived experience;Measures;Mediation;medication compliance;Methods;mortality;New York;Nongovernmental Organizations;novel;Outcome;Participant;peer;Persons;Pharmaceutical Preparations;Pilot Projects;programs;Provider;Public Health;Randomized;Recommendation;Recording of previous events;Recurrence;Research;Research Methodology;Research Priority;RNA;secondary outcome;Self Efficacy;Services;Site;social;social stigma;Social support;Source;South Africa;standard care;Surveys;tailored messaging;Testing;theories;therapy adherence;therapy outcome;treatment adherence;treatment as usual;Treatment outcome;Tuberculosis;tuberculosis treatment;Uganda;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Peer-led Implementation of TB-HIV Education and Adherence Counseling in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-A (03)]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: PROJECT NARRATIVE This proposal will perform in vitro studies to engineer HIV-specific CAR T cells with enhanced potency and ability to recognize low levels of HIV. Moreover, this proposal will use preclinical in vivo models to determine the ability of HIV-specific CAR T cells to fully suppress HIV replication.

PI_NAMEs: CLAIBORNE, DANIEL THOMAS (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Acute;Adherence;Antigens;antiretroviral therapy;Apical;Attenuated;Automobile Driving;Avidity;Binding;Binding Sites;Blood Cells;cancer cell;CD28 gene;CD4 Positive T Lymphocytes;cell killing;Cell membrane;Cell surface;Cell Therapy;Cells;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Chronic Disease;Clinic;clinical translation;Cytotoxic T-Lymphocytes;Data;density;design;Disease remission;Distal;Drug resistance;engineered T cells;Engineering;Epitopes;Exhibits;Face;Genetic Engineering;Goals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;humanized mouse;Immune response;Immunity;Immunotherapy;improved;In Vitro;in vivo;in vivo Model;Individual;insight;Intervention;Life;manufacture;Maps;Mediating;Membrane;Modality;Morbidity - disease rate;mortality;mouse model;Mutation;neutralizing antibody;Pathway interactions;Pattern;Peptides;Persons;Plasma;Polysaccharides;pre-clinical;prevent;refractory cancer;Research;Resistance;response;Specificity;success;T cell therapy;T-Cell Receptor Therapy;T-Lymphocyte;Testing;therapy adherence;Tissues;tool;Toxic effect;translational potential;Viral;Viral Load result;Viremia;Work

PROJECT_TITLE: Developing potent HIV-specific CAR T cells through optimizing antigen sensitivity

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it is aimed at elucidating the determinants of the U.S. drug overdose and HIV syndemic and factors that undermine the public health response. As such, the proposed research is specifically relevant to NIDA Priority Scientific Area #3: accelerating research on the intersection of substance use and HIV, and understanding the interplay of social and structural factors on the occurrence and distribution of substance use and associated behaviors and consequences (as expressed in NOT-DA-22-004). The proposed K24 award will also provide protected time to support mentorship of Early- Stage Investigators to achieve independently-funded academic careers in conducting patient-oriented research on substance use-associated syndemics.

PI_NAMEs: TSAI, ALEXANDER C (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Acceleration;Address;Architecture;Area;Award;Behavior;burden of illness;Burn injury;career;career development;Clinical;cohort;Cohort Studies;Collaborations;comorbidity;Data;Disease;Educational Curriculum;Epidemic;experience;Faculty;Funding;Funding Applicant;Goals;health disparity;HIV;innovation;interest;Intervention;K-Series Research Career Programs;Leadership;Literature;member;men;Mentors;Mentorship;Methods;Mid-Career Clinical Scientist Award (K24);Modeling;models and simulation;National Institute of Drug Abuse;novel;novel strategies;Outcome;Output;Overdose;Participant;patient oriented research;Persons;Pharmaceutical Preparations;Physicians;polysubstance use;Population;Postdoctoral Fellow;programs;prospective;psychological symptom;Public Health;Qualifying;Research;Research Personnel;research study;Research Support;response;Risk;Role;Running;Science;Scientist;Services;skills;Social Conditions;social factors;social health determinants;structural determinants;Structure;Students;substance use;syndemic;theories;Time;Traction;Training;transmission process;Violence;Woman;Work

PROJECT_TITLE: Mentoring in patient-oriented research on the U.S. substance use and HIV syndemic

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative Cryptococcal meningitis is a major life-threatening fungal infection in immuno-compromised patient populations including individuals with HIV/AIDS, organ transplant recipients, cancer patients receiving chemotherapeutics, and individuals on long-term corticosteroid treatment. Cryptococcus produces a unique cell type – the titan cell – that allows it to subvert the host immune response and cause disease. The proposed studies will determine the cellular and genetic changes in the titan cell that alter the immune response and will allow us to develop novel antifungal treatments to block titan cell production and immune modulatory treatments to restore proper immune function.

PI_NAMEs: NIELSEN, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adrenal Cortex Hormones;Affect;Alveolar Macrophages;Aneuploidy;anti-fungal agents;antimicrobial;Brain;Cancer Patient;cell capsule;Cell division;Cell surface;cell type;Cell Wall;Cells;Cellular Morphology;Cellular Structures;Cessation of life;Characteristics;chromosome replication;Chromosome Transfer;Classification;Clinical;Combined Modality Therapy;Complex;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Data;daughter cell;Death Rate;Diameter;Disease;Disease Outcome;DNA;DNA biosynthesis;Dwarfism;Environment;Eukaryotic Cell;Exhibits;experimental analysis;Failure;Fluconazole resistance;Foundations;Genetic;Genetic Variation;Genomics;Goals;Haploidy;Heritability;HIV;HIV/AIDS;Human;Immune;immune function;Immune response;Immune System Diseases;Immunity;Immunocompromised Host;immunoregulation;improved;In Vitro;in vivo;Individual;Infection;Inhalation;Investigation;latent infection;Life;Lung;Lung infections;Macrophage;Mediating;Modification;Molecular;Morphology;mortality;mouse model;mutant;Mutation;Mycoses;Natural Immunity;novel;organ transplant recipient;Outcome;pathogen;Pathogenesis;patient population;Patients;Pattern;Phagocytosis;Pharmacotherapy;Phase;Physiologic pulse;Ploidies;Polyploid Cells;Probability;Process;Production;reactivation from latency;Replication Error;Resistance;response;Role;Saccharomyces cerevisiae;spindle pole body;Stress;Testing;Th2 Cells;Therapeutic;Titan;trait;Virulence;Yeasts

PROJECT_TITLE: Impact of Cryptococcus titan cells on pathogenesis


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative: People of color are disproportionately affected by HIV and experience substantial disparities in the preexposure prophylaxis (PrEP) care continuum. The accessibility of community pharmacies and patient trust in pharmacists suggest that pharmacists can contribute significantly to increasing equity in PrEP care; however, implicit racial bias is common among healthcare providers, including pharmacists, and may reduce the effectiveness of pharmacist-led PrEP delivery. The primary aim of this project is to identify the feasibility, acceptability, and preliminary impact of an adapted evidence-based intervention in reducing implicit racial bias among pharmacists who have experience with or willing to prescribe PrEP in the future.

PI_NAMEs: SAEED, ABUBAKER  (contact)

PROGRAM_OFFICER_NAME: STIRRATT, MICHAEL JAMES

PROJECT_TERMS: acceptability and feasibility;Affect;Appointment;Area;Behavioral;Black Populations;Boston;Career Choice;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinic;Clinical Investigator;clinical trial analysis;Clinical Trials;Cognitive;college;Community Pharmacy;Consult;contextual factors;Continuity of Patient Care;Counseling;cultural competence;Data;design;Development;Disparity;Disparity population;disparity reduction;Doctor of Philosophy;Education;Educational process of instructing;effective intervention;Effectiveness;effectiveness outcome;Eligibility Determination;empowerment;Epidemic;Equity;Evidence based intervention;experience;feasibility testing;Feedback;Foundations;Funding;Future;Goals;Habits;health care disparity;Health Care Research;health equity;Health Personnel;Health Sciences;HIV;HIV disparities;implementation determinants;implementation framework;implementation intervention;implementation science;Implicit Association Test;implicit bias;improved;Incidence;Individual;Infection;innovation;Institution;interest;Internships;Intervention;Interview;Long-Term Effects;Massachusetts;Measures;Mentors;Methods;Modeling;Monitor;multidisciplinary;Outcome;Participant;Patients;people of color;Persons;Pharmacists;Pharmacy facility;Pharmacy Students;Phase;pilot trial;Play;Policy Maker;Positioning Attribute;post intervention;pre-exposure prophylaxis;Prejudice;Prevention;Process Measure;programs;Qualitative Methods;Qualitative Research;Race;racial bias;racial disparity;Randomized;recruit;Research;resilience;Risk;Role;simulation;simulation game;Societal Factors;Solid;Statistical Methods;Testing;Training;trial comparing;Trust;United States;United States National Institutes of Health;uptake;Washington;Work

PROJECT_TITLE: The Impact of an Intervention to Reduce Pharmacists' Racial Bias Towards People of Color at Risk of HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Prevention

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE The goal of this proposal is to pilot an integrated HIV service delivery intervention using a status neutral strategy in two emergency departments (ED) in South Africa. Given the high burden of HIV and people at high risk of HIV acquisition in the ED, we seek to integrate HIV testing, and pilot the provision of oral and long- acting pre-exposure prophylaxis (PrEP) to ED patients. We seek to understand the impact of these innovations on ED flow, and assess the feasibility for long term adoption of this strategy in the ED.

PI_NAMEs: BEKKER, LINDA-GAIL GAIL;HANSOTI, BHAKTI  (contact)

PROGRAM_OFFICER_NAME: STENSON, ANAIS FERN

PROJECT_TERMS: Acceleration;acceptability and feasibility;Accident and Emergency department;Acquired Immunodeficiency Syndrome;Action Research;Acute;Address;Adherence;Adopted;Adoption;Adult;Africa;AIDS prevention;Alcohol consumption;Anxiety;Caring;Cessation of life;Characteristics;Client;Climacteric;Clinical;Collaborations;Communities;comorbidity;Consultations;curative treatments;Data;demographics;Diagnosis;Discipline of Nursing;Eligibility Determination;Emergency Care;Emergency Department patient;Emergency department visit;Emergency medical service;Employment Status;Ensure;Epidemic;fighting;follow-up;Foundations;Goals;Grant;Health care facility;Health Personnel;Health system;high risk;HIV;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;improved;Incidence;innovation;Intervention;intervention delivery;Interview;Intoxication;Length of Stay;lens;Life;Link;Maps;Measures;men;Mental Depression;mortality;Nurses;Occupational Exposure;Oral;Pain;patient oriented;Patient Preferences;Patients;Persons;Physicians;Pilot Projects;Population;Positive Test Result;pre-exposure prophylaxis;Preparation;Prevalence;Prevention;prevention service;Prevention strategy;Preventive care;preventive intervention;Preventive treatment;primary outcome;Process;programs;Prophylactic treatment;Provider;Questionnaires;Race;Research;Resources;Risk;routine care;secondary outcome;seroconversion;service delivery;Service delivery model;Services;Shelter facility;Shoulder;Site;social;South Africa;Stream;Substance abuse problem;Surveys;tertiary care;Testing;theories;Therapeutic;Time;tool;trauma centers;treatment services;treatment strategy;Universities;uptake;Work;young man;young woman

PROJECT_TITLE: Universal Test and Connect: A Pilot Study of Comprehensive HIV Service Delivery in Emergency Care Settings in South Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-Y (03)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Mental Illness;Neurosciences;Psychosis;Serious Mental Illness

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative People with psychosis see the world differently than others (e.g., hallucinations), and they do not see some visual illusions as strongly as healthy people do. Because we have a good understanding of visual brain systems from animal research, we can pinpoint the problem with seeing an illusion to a particular neural circuit. This project will use techniques from visual neuroscience along with EEG, magnetic resonance spectroscopy, and behavioral measures to uncover how psychosis disrupts visual perception.

PI_NAMEs: SCHALLMO, MICHAEL-PAUL  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Animal Experimentation;Animal Model;behavior measurement;Brain;Clinical;Cognition;design;Deterioration;Development;Disease;Electroencephalography;Etiology;Glutamates;Hallucinations;Illusions;insight;Magnetic Resonance Spectroscopy;Measures;Nature;neural;neural circuit;neuromechanism;Occipital lobe;Perception;Persons;prevent;Process;Psychoses;response;Role;Sensory;severe mental illness;Symptoms;System;Techniques;Testing;tool;Visual;visual dysfunction;Visual Illusions;visual neuroscience;Visual Perception;visual processing;visual stimulus;Work

PROJECT_TITLE: Supplement for Neural mechanisms of early visual dysfunction in psychosis


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE (RELEVANCE) HIV-1 does not replicate in monkey cells (nor, by extension, in monkeys), limiting HIV-1 pathogenic studies, and our preliminary data in the proposal demonstrate that Env and receptor/co-receptor molecules are not determinants of cross-species barriers against HIV-1 infection into monkeys. Specifically, activation of the resting lymphocytes is required for replication of the entered HIV, and Nef of SIVpbj1.9 (SNef), but not HIV-1, can sufficiently activate T cells such that the entered SIVpbj1.9 replicates robustly in the resting T cells. Thus, we explore whether the substitution of HIV-1 nef with the corresponding SIVpbj1.9 can proficiently activate the resting simian T cells for the entered HIV-1 to replicate and hence eventually to induce AIDS in monkey, which is pivotal for elucidating the precise molecular function of Nef in viral pathogenesis and for the construction of the HIV-1/simian AIDS model.

PI_NAMEs: PARK, IN-WOO  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Adherence;Amino Acid Sequence;Apoptosis;Biological;Cell Communication;Cells;Chromosomes;Data;Development;Disparate;Engineering;Foundations;Generations;Genes;Genetic;HIV;HIV Long Terminal Repeat;HIV-1;Human;IL2 gene;Immune;immune function;Immune response;immunodeficiency;immunoregulation;In Vitro;in vivo;Infection;Length;Life Cycle Stages;Long Terminal Repeats;Lymphocyte;Macaca mulatta;Mediating;Modeling;Modification;Molecular;Monkeys;Motility;Mucous Membrane;Nucleotides;Pathogenesis;Pathogenicity;Peripheral Blood Mononuclear Cell;promoter;Proviruses;Reagent;receptor;recombinant virus;Recombinants;Rest;Role;Simian Acquired Immunodeficiency Syndrome;simian human immunodeficiency virus;SIV;Solid;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tropism;Vaccines;Vertebral column;Viral Genes;Viral Pathogenesis;Virus;Virus Replication

PROJECT_TITLE: Engineering simian-compatible HIV-1


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE Exposure to traumatic events is associated with increased HIV risk in adults, however for young, forcibly displaced persons this relationship is less clear. This proposal aims to explicate HIV risk for adolescent girls and young women (AGYW) displaced from the conflict in Cabo Delgado, Mozambique and initiate the development of a trauma-informed HIV prevention strategy targeting this group. Results of these aims will be used to further the development of a trauma-informed HIV prevention strategy for AGYW.

PI_NAMEs: CHANTRE, CATHERINE LIMA (contact)

PROJECT_TERMS: adolescent HIV prevention;Adolescent HIV risk;Adult;Affect;Africa South of the Sahara;Age;AIDS prevention;Anxiety;Behavioral;career;Cities;community based care;condoms;Conflict (Psychology);Couples;Cross-Sectional Studies;Data;Development;disorder risk;displaced person;Emergency Situation;Epidemiologist;Equation;experience;Exposure to;Family;Fellowship;Female Adolescents;Focus Groups;global health;Health;Health Personnel;Health Services;Health Status;high risk;HIV;HIV Infections;HIV risk;Human immunodeficiency virus test;implementation science;implementation strategy;Individual;Infection;informant;interpersonal therapy;Intervention;Interview;intimate partner violence;Mediating;Mediation;Mediator;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentors;Mentorship;Methods;migration;Modeling;Mozambique;multidisciplinary;Needs Assessment;Outcome Study;Persons;Population;Post-Traumatic Stress Disorders;pre-exposure prophylaxis;Prevalence;Prevention;Prevention strategy;Province;Research;Research Infrastructure;research study;Risk Behaviors;Role;Sampling;Scientist;sexual debut;Sexual Partners;sexual violence;social;Societies;Stress;stressor;Subgroup;Surveys;tool;Training;transactional sex;Trauma;traumatic event;Violence;Vulnerable Populations;Woman;Work;young woman

PROJECT_TITLE: The impact of forced migration on HIV vulnerability and prevention among internally displaced adolescent girls and young women in northern Mozambique


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Relevance statement In the proposed project, we will assess molecular pathways by which HIV proteins and morphine affect disease progression by inducing the release of extracellular bodies carrying RNA (& proteins) for transmission to neighboring cells, thereby propagating disease. These findings could have ramifications for the future development of therapeutic interventions for treatment of neuroinflammation in HIV infected opioid abusers.

PI_NAMEs: BUCH, SHILPA J. (contact);SIL, SUSMITA

PROJECT_TERMS: Affect;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;Autophagocytosis;base;behavior test;Biological Assay;biomarker discovery;Brain;brain tissue;Cell Communication;Cells;Central Nervous System;chemokine;Chemosensitization;comorbidity;Confocal Microscopy;Coupled;cytokine;cytotoxic;cytotoxicity;Data;Development;Disease;Disease Progression;DLG4 gene;Down-Regulation;Drops;Drug usage;Drug Use Disorder;efficacy testing;Engineering;Epidemic;Excitatory Synapse;exosome;Exposure to;extend lifespan;extracellular;extracellular vesicles;Frequencies;functional outcomes;Future;Gene Expression;Genetic Transcription;gephyrin;Health;Hippocampus;HIV;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;Impaired cognition;Impairment;improved;in vivo;in vivo evaluation;Incidence;Individual;Inhibitory Synapse;Injections;injured;Injury;interest;Investigation;life span;Lipid Binding;Lipids;Long-Term Potentiation;Luciferases;Macaca;Measures;Mediating;Mediator;Messenger RNA;MicroRNAs;Modality;Modeling;Molecular;Morphine;morphine administration;Morphology;nanosized;Nerve Degeneration;neuroAIDS;Neurocognitive Deficit;neuroinflammation;neuroligin 2;Neuronal Injury;Neurons;neuropathology;novel;Opioid;Opioid abuser;opioid misuse;opioid use;opioid use disorder;Pathway interactions;PBX3 gene;Penetration;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;postsynaptic;posttranscriptional;Proteins;Rattus;Regimen;Reporter;Residual state;response;RNA;Rodent Model;Role;small hairpin RNA;Small Interfering RNA;Source;Synapses;synaptic function;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic RNA;Tissues;Trans-Activators;Transcription Coactivator;Transfection;Transgenes;Transgenic Organisms;transmission process;Untranslated RNA;Up-Regulation;uptake;Validation;Vertebral column;Vesicle;vesicular release;Viral Proteins;Viremia;Western Blotting

PROJECT_TITLE: HIV Tat and Opiate-mediated aberrations in glial-neuronal crosstalk: Implications for the role of extracellular RNA in HAND


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative  This combined cross-sectional and longitudinal study will show whether central auditory tests could offer value for assessing or predicting the central nervous system effects of HIV infection in children and adolescents. Diagnosing and monitoring of central nervous system co-morbidities is essential in HIV infection, and central auditory tests may offer a simpler, easier to perform way to assess this than current techniques. This could alter clinical practice if central auditory tests are shown to be useful for screening for or predicting central nervous system effects in children and adolescents living with HIV in resource-limited settings.

PI_NAMEs: BUCKEY, JAY C (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: Adolescence;Adolescent;Affect;Age;antiretroviral therapy;Area;Attention;Auditory;Auditory system;Brain;Caring;Central Nervous System;Child;Childhood;clinical practice;Clinical Trials;Cognition;Cognitive;cognitive performance;cognitive testing;cohort;Cohort Studies;Collaborations;Communicable Diseases;comorbidity;Complex;Consequences of HIV;Cross-Sectional Studies;Data;Development;Developmental Delay Disorders;Diagnosis;Disabling;Ear;Education;Electrophysiology (science);Employment;executive function;experience;Frequencies;Goals;Hearing Tests;HIV;HIV Infections;HIV-infected adolescents;improved;Individual;innovation;International;Intervention;Language;Life;literacy;Longitudinal Studies;low and middle-income countries;Measures;Memory;mental development;Mental Health;Monitor;Neurocognitive;Neurocognitive Deficit;neurocognitive test;Neuropsychological Tests;Noise;Nursery Schools;Outcome;Pediatrics;peer;Performance;performance tests;Pharmaceutical Preparations;Play;Problem behavior;Process;processing speed;Productivity;Quality of life;Reading;Resource-limited setting;Resources;response;Risk;Role;Schools;screening;Short-Term Memory;skills;social;Socioeconomic Status;sound;speech in noise;Tanzania;Techniques;Teenagers;Test Result;Testing;Time;treatment adherence;wireless;Work

PROJECT_TITLE: How sound processing in the ear and brain relates to educational outcomes, mental health, and quality of life in adolescents living with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project examines whether state laws used to restrict children’s social media exposure reduce exposure to unhealthy food and beverage marketing. Exposure to unhealthy food and beverage marketing is linked to poor diet among youth, which increases their risk for developing diabetes, heart disease, and cancer.

PI_NAMEs: BRAGG, MARIE ;ELBEL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescent;Advertising;aged;Amendment;Attention;Beverages;Black race;Budgets;Child;Child Health;Coca;Code;Constitution;cost;court;Data;Data Collection;design;Diabetes Mellitus;diabetes risk;Diet;digital media;Disease;Disparity;Enrollment;ethnic difference;Exposure to;Food;food marketing;health disparity;health equity;Heart Diseases;Hispanic;Hour;Income;innovation;Laws;Link;Louisiana;Low income;Malignant Neoplasms;Marketing;Measures;media use;Obesity;Policies;Policy Analysis;Procedures;racial difference;Reducing diet;Reporting;response;Risk;Sampling;Shapes;Site;social media;Speech;Techniques;Texas;Time;Unhealthy Diet;United States;Utah;Youth

PROJECT_TITLE: Unhealthy food and beverage advertising on social media: Examining state policies that restrict adolescents' access to social media

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-1 (M6)]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE. Human immunodeficiency virus (HIV) remains a considerable burden in healthcare. We are developing a new therapy that could enhance the ability of people living with HIV to control the virus by reprograming B cells to secrete potent anti-HIV antibodies. This technology could also be applicable to a wide range of diseases, including cancer, and other infectious diseases.

PI_NAMEs: MATHUR, ATISHAY  (contact)

PROJECT_TERMS: Adaptive Immune System;Address;adeno-associated viral vector;Antibodies;antibody engineering;Antibody Therapy;Antigen Presentation;Antigen Targeting;Antigens;antiretroviral therapy;Antitumor Response;B cell therapy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocyte Subsets;B-Lymphocytes;Biological Models;Bypass;career;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Compartmentation;Cell Line;Cell model;Cell Physiology;Cell surface;Cell Therapy;Cells;Cellular biology;chimeric antigen receptor;Chronic;Clinic;Clinical;clinical practice;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communicable Diseases;comorbidity;Custom;Cyclic GMP;Defect;design;Development;Disease;Doctor of Philosophy;Engineering;Environment;Exhibits;experience;Fellowship;Frequencies;Funding;gene therapy;gene-editing approach;Genes;Goals;Healthcare;Helper-Inducer T-Lymphocyte;HIV;HIV Antibodies;HIV Antigens;HIV Envelope Protein gp120;HIV Infections;HIV therapy;HIV-1;Human;Human Engineering;humanized mouse;Immune;Immunization;Immunoglobulins;improved;In Vitro;in vivo Model;Inflammation;Infusion procedures;Innate Immune System;interest;Malignant Neoplasms;Medicine;Membrane;Memory B-Lymphocyte;memory recall;Mentors;Modeling;mouse model;Mus;Muscle;neutralizing antibody;novel;novel therapeutics;Organoids;peripheral blood;Persons;Pharmaceutical Preparations;Phase;Physicians;Plasma Cells;Play;prevent;programs;Protein Isoforms;Regulation;Reporter;Research;Residual state;response;Role;Sampling;Scientist;sensor;Series;Signal Transduction;Signaling Molecule;skills;Supporting Cell;synthetic protein;T-Lymphocyte;Technology;Therapeutic;Therapeutic antibodies;Time;Tissues;Tonsil;tool;Training;training opportunity;Training Programs;Vaccination;vaccine development;Vaccines;Virus;Virus Replication;wasting;Work

PROJECT_TITLE: Engineering B cells for enhanced HIV control


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Efforts to mitigate HIV among African American women have not been sufficient to level persistent HIV inequities and limited attention has been afforded to examining how migration complicates HIV service engagement barriers and social support networks that shape HIV testing and treatment among this HIV- vulnerable population. This study aligns with National HIV/AIDS Strategy and NIH priorities to advance understanding of how human mobility affects (dis)engagement with the HIV prevention and care cascade and to develop strategies to address these challenges.

PI_NAMEs: HILL, MIRANDA  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Administrator;Advocate;Affect;African American;African American Women;AIDS prevention;American;Assessment tool;Attention;career development;Caring;Cause of Death;Characteristics;Cities;Clinical;Clinical Trials;cohort;Communities;community setting;Complex;Consult;Data;Data Analyses;design;Destinations;Development;Diagnosis;Epidemic;Equity;Evaluation;evaluation/testing;Focus Groups;Gender;global health;Goals;Health;Health behavior;health determinants;Health Services Accessibility;high risk;HIV;HIV diagnosis;HIV disparities;HIV Infections;HIV risk;HIV/AIDS;Human;Human immunodeficiency virus test;implementation intervention;improved;Incidence;Inequity;innovation;insight;International;Interpersonal Relations;Intervention;intervention mapping;Interview;Knowledge;Link;Measures;Medical;Mentors;Methods;Migrant;migration;mortality;multidisciplinary;multilevel analysis;Network-based;novel;Outcome;outreach;Pathway interactions;Personal Satisfaction;Population;Prevalence;Prevention;Provider;public health research;Race;Regression Analysis;Research;Research Methodology;residence;Risk;Scientist;Series;service engagement;service intervention;Services;Shapes;Site;skills;social;Social Network;social network intervention;social science research;Social support;Statistical Data Interpretation;Structure;Subgroup;Surveys;System;therapy design;Time;tool;Training;transmission process;treatment disparity;Treatment outcome;trend;Underserved Population;United States National Institutes of Health;Vulnerable Populations;White Women;Woman;Women's Group

PROJECT_TITLE: Unveiling Pathways to Ending HIV Among African American Women: Leveraging Social Networks to Enhance HIV Testing and Treatment Engagement Among  Migrants


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ATLANTA

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGIA STATE UNIVERSITY

ORG_STATE: GA

PHR: Public Health Relevance Statement Narrative HIV is a constantly changing virus, and current treatments face limitations. Our research on nanobodies aims to discover simpler and more effective ways to combat HIV, potentially revolutionizing treatment approaches for better health outcomes.

PI_NAMEs: XU, JIANLIANG  (contact);XU, KAI

PROGRAM_OFFICER_NAME: SALAZAR-GONZALEZ, JESUS FIDEL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Affinity;Animals;Antibodies;antibody engineering;Antigens;antiretroviral therapy;Bacteriophages;base;Binding Sites;Bioinformatics;combat;Complex;design;Development;Drug Kinetics;Electron Microscopy;Engineering;env Gene Products;Epitopes;Face;Geometry;global health;glycosylation;Goals;Half-Life;Health;health care availability;health care disparity;HIV;HIV therapy;HIV-1;Human;IgG1;Immunization;Immunize;immunogenic;Individual;innovation;insight;Intervention;Investigation;Libraries;Light;Link;Molecular Conformation;Mutation;nanobodies;neutralizing antibody;novel;Outcome;particle;Pathway interactions;Penetration;Peptides;Phage Display;preservation;Prevention;prophylactic;Protocols documentation;public health relevance;rational design;Research;Resistance;Resistance development;scaffold;screening;Site;social stigma;Structure;success;Techniques;Testing;Therapeutic;Tissues;tool;Treatment Effectiveness;Treatment Efficacy;treatment strategy;Vaccines;Variant;Viral;viral resistance;Virus;X-Ray Crystallography

PROJECT_TITLE: Development of Broadly Neutralizing Nanobodies for Advancing AIDS Therapy


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases;Prevention

ORG_NAME: EMORY UNIVERSITY

PHR: Narrative To reach Ending the Epidemic (ETE) targets, we will need consistent national HIV pre-exposure prophylaxis (PrEP) data to describe patterns of use, and to understand which programs and policies are effective at facilitating PrEP uptake. We propose to build on our history of developing public PrEP data resources and innovative metrics of PrEP use in PREMISE (PrEP Epidemiology, Modeling, and Surveillance), a collaborative and interdisciplinary group that will use national PrEP data, along with legal and policy coding, to inform the US HIV epidemic response. The study will conduct analyses regarding the scope and equity of PrEP scaleup over time, and will perform analyses to explore the impact of different locality-specific programs and policies on PrEP starts and PrEP equity.

PI_NAMEs: SIEGLER, AARON JULIUS (contact);SULLIVAN, PATRICK SEAN

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: AIDS prevention;Area;Black Populations;Caring;Code;Collaborations;Communicable Diseases;community organizations;cost;Cost Effectiveness Analysis;Data;Data Collection;data resource;Data Set;Diagnosis;Economics;Effectiveness;Eligibility Determination;Environment;Epidemic;epidemic response;Epidemiology;Equity;Ethnic Origin;experience;Experimental Designs;Formulation;Funding;Future;Growth;Health;health equity;HIV;improved;improved outcome;Individual;Inequity;Injectable;innovation;Investigation;Investments;Latinx population;Laws;Lead;Legal;Light;Maintenance;Maps;mathematical model;Medicaid;Medical Records;Modality;Modeling;Natural experiment;Pathway interactions;Pattern;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Policies;Population;population health;pre-exposure prophylaxis;programs;Public Health;Quasi-experiment;Race;Recording of previous events;Resources;scale up;Site;social media;Source;Structure;System;Telemedicine;Time;Training;uptake;Woman;Work

PROJECT_TITLE: Establishing PREMISE: A PrEP Epidemiology, Modeling, and Surveillance System


PHR: Project Narrative This project will use a potent small-molecule compound that mimics human CD4 to synergize with antibodies present in the plasma of people living with HIV (PLWH) to render virus-infected cells susceptible to killing by immune cells. The significance of this early intervention approach stems from its ability to drastically reduce the HIV-1 reservoir to an extent that HIV-1 infection can potentially be controlled by the body’s own immune system in the absence of life-long combination antiretroviral therapy.

PI_NAMEs: FINZI, ANDRES ;KUMAR, PRITI  (contact);SODROSKI, JOSEPH G

PROGRAM_OFFICER_NAME: SANDERS, BRIGITTE E

PROJECT_TERMS: Aftercare;Antibodies;Antibody Binding Sites;Antibody Specificity;Antibody Therapy;antibody-dependent cell cytotoxicity;antiretroviral therapy;arm;Binding;Binding Sites;CD4 Antigens;CD4 Positive T Lymphocytes;Cell Physiology;Cell surface;Cells;Clinical Trials;Development;Dimensions;Early Intervention;Effector Cell;Epitopes;Equilibrium;Exposure to;Family;Generations;Glycoproteins;HIV;HIV Envelope Protein gp120;Human;human model;humanized mouse;IgG1;IgG3;Immune;immune clearance;Immune response;Immune system;Immunoglobulin G;immunoregulation;improved;In Vitro;in vivo;indoline;Interruption;Intervention;Longevity;Mediating;mimetics;Molecular Conformation;Mus;Natural Killer Cells;novel strategies;Organizational Objectives;Outcome;Persons;Phenotype;Physiological;Physiology;Plasma;Predisposition;prevent;Property;Proviruses;receptor binding;Regimen;Research;response;screening;single cell analysis;small molecule;stem;synergism;Techniques;Time;Tissues;Translations;Variant;Viral;Viral Load result;Viral Proteins;viral rebound;Viral reservoir;Viremia;Virus;Virus Diseases;virus envelope;Virus Replication;Withdrawal

PROJECT_TITLE: Targeting the HIV-1 reservoir at cART initiation with CD4-mimetic interventions


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

PHR: NARRATIVE People living with HIV are at an increased risk for oropharyngeal cancer (OPC) and oral human papillomavirus, which causes >70% of OPCs. Research on oral HPV infection requires long-term follow-up studies of large numbers of diverse PLWH. We aim to evaluate if self-collected oral HPV DNA tests sent through the mail accurately identify participants with oral HPV infection as pilot data for a future prospective cohort study investigating risk factors and salivary biomarkers of persistent oral HPV infection and early HPV-OPC.

PI_NAMEs: HERNANDEZ, ALEXANDRA LYDIA (contact)

PROGRAM_OFFICER_NAME: BACCAGLINI, LORENA

PROJECT_TERMS: acceptability and feasibility;Address;Agreement;Alcohols;Anus;Benefits and Risks;Biological Markers;Black race;Cancer Etiology;carcinogenesis;Categories;Cervical;Clinic;Clinic Visits;co-infection;cohort;Collection;cost;Cost Savings;Data;design;Diagnosis;Disease;Disparity;DNA;Eligibility Determination;ethnic difference;ethnic diversity;ethnic identity;ethnic minority population;Ethnic Origin;Ethnic Population;Evaluation;follow-up;Follow-Up Studies;Funding Mechanisms;Future;General Population;High Prevalence;high risk population;HIV;Home;home test;Hour;HPV oropharyngeal cancer;HPV positive;HPV-High Risk;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Incidence;Individual;Infection;Instruction;Longterm Follow-up;Malignant Neoplasms;malignant oropharynx neoplasm;member;men;Mentors;Methods;Mouthwash;National Institute of Dental and Craniofacial Research;novel;Oral;oral HPV;oral HPV infection;Participant;Persons;Pilot Projects;Population Heterogeneity;potential biomarker;Prevalence;Prevention;Procedures;Prospective Studies;Prospective, cohort study;Race;racial difference;racial disparity;racial diversity;racial population;recruit;Refrigeration;Research;Research Personnel;Risk;Risk Assessment;Risk Factors;Role;saliva sample;Salivary;sample collection;Sampling;screening;Screening for cancer;sexual minority men;Shipping;Site;Specimen;Survival Rate;Swab;Testing;Time;Viral

PROJECT_TITLE: Persistent oral HPV among diverse PLWH: A pilot study to evaluate the feasibility and acceptability of testing for oral HPV DNA infection with mail-delivered sample collection kits.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Human Fetal Tissue;Immunotherapy;Infectious Diseases;Prevention

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE With an estimated 1.3 million new infections and over 600,000 AIDS-related deaths in 2022, the HIV-1 epidemic continues to pose a significant public health challenge worldwide. A better understanding of the immediate immune response to HIV-1 infection would help design better vaccine and therapeutic strategies, but these early events are largely understudied due to the absence of suitable in vivo experimental models. We propose to fill this gap using an innovative humanized mouse model that we recently developed, combined to a new protocol for genetic engineering of these animals.

PI_NAMEs: RONGVAUX, ANTHONY  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;acute infection;adaptive immunity;Address;Affect;Animal Model;Animals;Antibodies;Antigens;Binding;Biology;Cell surface;cell type;Cells;Cessation of life;chemokine;Complement;Contracts;Cyclic GMP;cytokine;cytokine release syndrome;Dendritic Cells;design;Detection;Development;Disease;Disease Progression;Endosomes;Epidemic;Event;Experimental Models;experimental study;Exposure to;Family;Genes;Genetic;Genetic Engineering;high risk;HIV therapy;HIV-1;Human;human pathogen;humanized mouse;Immune;Immune response;Immune system;Immunity;Immunocompetent;immunological intervention;immunopathology;In Vitro;in vivo;Infection;Inflammation;Inflammatory Response;Influenza A virus;innate immune mechanisms;Innate Immune Response;innate immune sensing;innovation;insight;Intravenous;Knock-out;knockout gene;Knowledge;Macrophage;Measures;Membrane;Modeling;Molecular;monocyte;mouse model;Mucous Membrane;Mus;Natural Immunity;Natural Killer Cells;novel;Nucleic Acids;pathogen;Pathogen detection;Pathway interactions;permissiveness;Phase;Prevention;Prevention strategy;Production;Prospective cohort;Prospective, cohort study;Protocols documentation;Public Health;receptor;Research;Resolution;response;reverse genetics;Role;Route;Sampling;sensor;Sentinel;Serum;Simplexvirus;Source;System;Testing;Therapeutic;Toll-like receptors;tool;transcriptome;transmission process;treatment strategy;vaccine candidate;Vaccines;Viral;viral detection;Viral Load result;Viral Physiology;viral resistance;Virus;Virus Diseases;Virus Replication;volunteer;ZIKA

PROJECT_TITLE: In vivo innate immune sensing of HIV-1 infection


ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE HIV mutations induced by human APOBEC3 enzymes can block viral replication or lead to drug resistance. Our data suggest that the processes involved in HIV mutagenesis are donor-specific. This project aims to identify the underlying genetic variations in both human and HIV using a combination of quantitative and experimental methods.

PI_NAMEs: EBRAHIMI, DIAKO  (contact)

PROJECT_TERMS: Alternative Splicing;Anti-retroviral drug resistance;antiretroviral therapy;antiviral immunity;APOBEC3F gene;APOCEC3G gene;Big Data;Bioinformatics;Biology;Cessation of life;Clinical;clinical predictors;Complex;Coupled;Data;Data Set;data-driven model;Development;Disparate;Drug resistance;effective therapy;Enzymes;Evolution;Exhibits;Family;Genes;Genetic;Genetic Determinism;genetic information;Genetic Polymorphism;Genetic Variation;Genome;Genomic Segment;global health;Goals;Haplotypes;Health;health disparity;HIV;HIV Genome;HIV Infections;HIV Seropositivity;HIV-1;HIV-1 protease;Human;Immune Evasion;Immunity;Immunologics;Incidence;Individual;individualized medicine;Induced Mutation;Infant;Infection;Knowledge;Lead;Link;Mediating;Methods;Modeling;Molecular;Mothers;Mutagenesis;Mutation;nonhuman primate;optimal treatments;Outcome;pathogen;patient response;Patients;Pattern;Persons;Population;predictive modeling;Process;Production;Protease Inhibitor;Protein Isoforms;Proteins;Proteomics;Proviruses;Reporting;Resistance;response;Role;SIV;Standardization;Techniques;Terminator Codon;Testing;transcriptomics;treatment strategy;Variant;vif Genes;Viral;Virus;virus genetics;Virus Replication;World Health Organization

PROJECT_TITLE: Viral and host determinants of donor-specific anti-HIV/SIV immunity mediated by APOBEC3-enzyme


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Mobility, especially unexpected travel, puts men living with HIV in sub-Saharan Africa at risk of HIV treatment interruption and poor health outcomes. By refining and piloting an intervention to reduce treatment interruption among mobile men in Malawi, the proposed project will provide knowledge on how to improve treatment outcomes among this vulnerable population. The project has the potential to improve public health by improving viral suppression among mobile men living with HIV, a critical population in the effort to end the HIV epidemic.

PI_NAMEs: THORP, MARGUERITE  (contact)

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Adult;Africa South of the Sahara;antiretroviral therapy;Appointment;arm;barrier to care;Board Certification;California;career;career development;Caring;CD4 Lymphocyte Count;Client;Climacteric;clinical implementation;Clinical Trials;Collaborations;community advisory board;Complex;Consultations;Counseling;Data;Development;Development Plans;Educational Curriculum;effective intervention;Effectiveness;Effectiveness of Interventions;Emergency Situation;Employment;Ensure;Environment;Epidemic;epidemic response;Ethics;Evaluation;experience;Focus Groups;Future;Gender;global health;Goals;Grant;Health care facility;Health Personnel;Health Services Accessibility;Health system;high risk men;HIV;HIV/TB;Home;Hotlines;implementation science;Improve Access;improved;Income;Infection;Internal Medicine;International;Interruption;Intervention;intervention refinement;Interview;Kenya;Knowledge;Los Angeles;Malawi;male;marginalized population;Medical;men;Mentored Research Scientist Development Award;Mentorship;Mobility decline;Modeling;Monitor;Mozambique;novel;Outcome;Pediatrics;Physicians;poor health outcome;Population;Postdoctoral Fellow;primary outcome;Problem Solving;Procedures;Public Health;Randomized;Randomized, Controlled Trials;Research;Research Personnel;Resources;Risk;Running;Scientist;secondary outcome;service delivery;Services;Sexual Partners;skills;Southern Africa;systems research;Testing;Time;Training;training opportunity;transmission process;Travel;Treatment outcome;treatment program;treatment risk;trial design;Universities;Viral;Viral Load result;Viremia;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Reducing Mobility-associated Interruption in ART among Men in Malawi (ReMIT)


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHYSICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative: We will investigate what holds the immature HIV lattice together and how dynamics propagate through the lattice. We will then establish if these dynamics drive the auto-processing of Gag- Pol, which is the first step of the HIV maturation process.

PI_NAMEs: SAFFARIAN, SAVEEZ  (contact);VERSHININ, MICHAEL D

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Anti-viral Agents;antiviral drug development;Architecture;Award;Binding;Biochemical;Biomechanics;biophysical techniques;CASP1 gene;Cells;cofactor;Collaborations;comparative;Computing Methodologies;crosslink;Data;Defect;design;Diffusion;Enzymes;Equilibrium;experimental study;Funding;Future;gag Gene Products;Goals;Guide RNA;HIV;HIV-1;HIV-2;imaging modality;in silico;In Vitro;inhibitor;Kinetics;Measurement;Measures;melting;Membrane;Methodology;Microscopic;Minority;Modeling;Molecular;monomer;Mutation;Nature;next generation;Optical Methods;Peptide Hydrolases;Physiological;Play;pol genes;Positioning Attribute;Process;Proteins;Proteolysis;Reaction;recruit;Role;Structure;System;Testing;Viral;Virion;Virus

PROJECT_TITLE: Architecture and dynamics of immature HIV lattice


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WATERLOO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY OF WATERLOO

ORG_STATE: ON

ORG_ZIPCODE: N2L 3G1

PHR: Project Narrative We will apply our newly developed adaptive optics fluorescence lifetime ophthalmoscopy (AOFLIO) to non-invasively image at the cellular-scale lipofuscin fluorescence from the retinal pigment epithelium (RPE) layer, examining both RPE structure and a functional biomarker of the photoreceptor/RPE complex. With normal aging and in patients with Stargardt disease, changes in fluorescence lifetime that may be related to variations in the composition of lipofuscin or the presence of additional fluorophores, such as melanin, will be recorded and compared. AOFLIO has the potential to improve monitoring of disease progression, and evaluation of developing treatments.

PI_NAMEs: HUNTER, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Acceleration;adaptive optics;Adult;Age;age group;age related changes;Atrophic;Biochemical;Biological Markers;Blindness;Cells;Cellular Structures;Characteristics;Clinical;Clinical Trials;comparative;Complex;Computer software;Custom;Cytoplasmic Granules;Data;data acquisition;design;Development;Diagnosis;Disease;Disease Progression;Electronics;Environment;environmental change;Evaluation;experimental study;Eye;Eye diseases;Feedback;Fluorescence;fluorescence imaging;fluorescence lifetime imaging;fluorophore;Foundations;Future;Health;healthy aging;high resolution imaging;Human;human subject;Image;imaging modality;improved;in vivo;in vivo imaging;Individual;inherited retinal degeneration;innovation;instrumentation;Investigation;Lateral;Learning;Life;Light;Lipofuscin;macula;Measurement;Measures;Melanins;Methodology;Molecular;Monitor;mosaic;Mutation;Nature;new technology;non-invasive imaging;normal aging;novel therapeutics;Ophthalmoscopes;Ophthalmoscopy;Patients;Performance;Persons;Phase;Phenotype;photon-counting detector;Photons;Photoreceptors;prospective;prototype;regional atrophy;Research;Resolution;Retina;Retinal Degeneration;Retinal Diseases;Retinal Dystrophy;Sampling;Scanning;Source;Sparrows;Stargardt's disease;Structure of retinal pigment epithelium;System;temporal measurement;tool;Variant;Visualization;Waste Products

PROJECT_TITLE: Adaptive Optics Fluorescence Lifetime Ophthalmoscopy (AOFLIO) in healthy people and with disease


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: East Greenwich

ORG_NAME: CREMEDICAL CORPORATION

ORG_STATE: RI

PHR: PROJECT NARRATIVE By providing significantly higher fidelity which leads to improved sensitivity/specificity, tEEG will resolve conventional EEG’s major drawback and a fundamental problem that clinicians and researchers have been struggling with for decades. tEEG may advance diagnosis and fill unmet clinical and research needs. Commercially, tEEG promises to transform the market landscape and set a new standard for EEG equipment.

PI_NAMEs: BESIO, WALTER GRANT (contact)

PROGRAM_OFFICER_NAME: GROSS, BROOKS ANDREW

PROJECT_TERMS: Alpha Rhythm;Blinking;Brain;Brain Diseases;brain electrical activity;Clinical;Clinical Protocols;Clinical Research;clinical risk;clinical trial protocol;Clinical Trials;commercialization;Communities;Complex;Computer Simulation;computerized;Data;design;design verification;Detection;Development;Devices;Diagnosis;Diffuse;Effectiveness;Electrocardiogram;Electrodes;Electroencephalography;Epilepsy;Equipment;Evaluation;experience;Frequencies;Head;High Frequency Oscillation;improved;Industry Standard;innovation;Institutional Review Boards;interest;manufacture;Marketing;Measures;Morphologic artifacts;multidisciplinary;Muscle;neurophysiology;Noise;Patients;Pattern;Persons;Phase;Preclinical Testing;Preparation;Process;prototype;Reader;Regulatory Affairs;Research;research clinical testing;Research Personnel;Resolution;Rest;Safety;Seizures;Sensitivity and Specificity;sensor;Signal Transduction;Site;Small Business Innovation Research Grant;success;System;Technology;Testing;Time;usability;Visual;voltage

PROJECT_TITLE: Epilepsy Seizure Detection with Innovative Tripolar EEG (tEEG)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Transplantation

ORG_CITY: SAN DIEGO

ORG_NAME: AUXILIUM BIOTECHNOLOGIES INC.

PHR: Peripheral nerve gap injuries occur in 3% of all trauma cases and 30% of combat injuries to the extremities, resulting in a loss of five million working days each year and direct medical costs of $150 billion annually. Auxilium Biotechnologies Inc. proposes to develop for human use the NeuroSpan Bridge, a biomimetic, multi-channel scaffold that exhibits bioequivalency or superiority to human sural nerve autografts to support functional regeneration after injuries over gap lengths up to 3 centimeters.

PI_NAMEs: KOFFLER, YACOV  (contact)

PROGRAM_OFFICER_NAME: WU, GUANGYING

PROJECT_TERMS: Acceleration;Agreement;Allografting;Animal Model;Autologous;Autologous Transplantation;axon regeneration;Biomedical Engineering;Biomimetics;Biotechnology;chronic pain;Clinic;Clinical;clinical implementation;Clinical Research;clinical research site;Clinical Trials;combat injury;commercialization;cost;cost effective;Data;design verification;Development;Device or Instrument Development;Devices;Dimensions;Distal;Exhibits;Facial Nerve Injuries;Fascicle;follow-up;Functional Regeneration;Hand;Human;improved;Industry;Infrastructure;Injury;Institutional Review Boards;interest;Label;Leg;Length;Licensing;limb injury;manufacture;manufacturing process;Marketing;Medical Care Costs;Medical Device;meetings;Modeling;Morbidity - disease rate;Muscle;Nerve;nerve autograft;nerve gap;nerve injury;nerve repair;Neurology;Neuroma;neurosurgery;Operative Surgical Procedures;Outcome;participant enrollment;Patients;Peripheral nerve injury;peripheral nerve repair;Peripheral Nerves;Phase;Phase II Clinical Trials;pre-clinical;preclinical development;preclinical study;Process;programs;Quality of life;Ramp;Recovery;Reporting;Safety;scaffold;Site;Source;Spinal Cord;standard of care;Sterilization;Structure;sural nerve;Surgeon;Technology;Testing;Therapeutic Equivalency;Time;Toxicology;Trauma;Tube;Vendor;Weight;Work;wound

PROJECT_TITLE: The Neurospan Bridge: A Device for Peripheral Nerve Repair

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders C Study Section[NSD-C]


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pain Research;Pediatric;Peripheral Neuropathy;Rare Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The significance of the current grant is that after several years of medicinal chemistry optimization, we have a very promising small-molecule splicing drug (PTC680) that can correct the splicing defect responsible for familial dysautonomia, a rare neurodegenerative disease that affects the development and survival of sensory and autonomic neurons. The goal of this proposal is to complete IND-enabling studies for PTC680, obtain IND approval for our drug, and conduct a Phase I clinical trial taking full advantage of the expertise and guidance of BPN consultants and contractors.

PI_NAMEs: SLAUGENHAUPT, SUSAN A (contact)

PROGRAM_OFFICER_NAME: CYWIN, CHARLES L

PROJECT_TERMS: Affect;Age;autonomic neuropathy;Binding Proteins;Brain;Cells;Central Nervous System;Clinic;Clinical;clinical development;Clinical Trials;Communication;Complex;Congenital Neuropathy;Contractor;cost;Cytokinins;Data;Defect;Development;Disease;disease phenotype;Drug Interactions;Drug Screening;exon skipping;Familial Dysautonomia;first-in-human;Formulation;Funding;Gait;Gait Ataxia;Goals;Grant;Hand;Hereditary Sensory and Autonomic Neuropathies;humanized mouse;Impaired cognition;improved;In Vitro;in vivo;Individual;innovation;Kinetins;Laboratories;Lead;Life;meetings;Messenger RNA;Modification;mouse model;Mus;Mutation;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurologic;neuronal survival;Neurons;novel therapeutics;Pain;patient population;patient retention;Patients;Perception;Peripheral Nervous System;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Phenotype;Plants;Polymorph;pre-clinical;Preparation;prevent;Program Development;programs;protein complex;Proteins;Retinal Degeneration;RNA Splicing;Running;scale up;Schedule;Scheme;screening;Sensory;sensory neuropathy;Severity of illness;small molecule;Sodium Chloride;stretch reflex;Suspensions;Tablets;Temperature;Therapeutic;therapy development;Time;Tissues;Translating;translational medicine;Tween 80;United States National Institutes of Health;Work

PROJECT_TITLE: Development of a splicing modulator compound for familial dysautonomia


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: NEUROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: There is no approved treatment that stabilizes or reverses cognitive decline in Parkinson’s disease. Intermittent deep brain stimulation (DBS) of the Nucleus Basalis of Meynert (NBM) offers the potential to stabilize the deleterious effects of the cholinergic system in PD and its negative impact on cognitive and cognitive-motor function. We will establish the safety, tolerability, and feasibility of combined continuous subthalamic nucleus (STN) and intermittent NBM DBS for people with Parkinson’s disease and mild cognitive and cognitive-motor impairment using novel tractography defined targets and novel patterned stimulation to lay the groundwork for a future pivotal clinical trial.

PI_NAMEs: BRONTE-STEWART, HELEN  (contact)

PROGRAM_OFFICER_NAME: ROBINSON SCHWARTZ, SARAH ELIZABETH

PROJECT_TERMS: 3-Dimensional;Anterior;Atrophic;Attention;Basal Nucleus of Meynert;Behavioral;Blood flow;Blood Glucose;Boston;Calibration;cholinergic;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive impairment in Parkinson's;Computer software;Data Set;Deep Brain Stimulation;Dementia;Dementia with Lewy Bodies;density;Deterioration;Devices;Diffusion;Electrodes;evidence base;executive function;Fiber;first-in-human;fluorodeoxyglucose positron emission tomography;Frequencies;Future;Globus Pallidus;glucose metabolism;Goals;Growth Factor;high standard;Hour;human study;human subject;Impaired cognition;Impairment;Implant;implantation;improved;Individual;Intervention;Lateral;Lead;lead optimization;Link;Location;Measures;mild cognitive impairment;Modeling;Motor;motor control;motor impairment;motor symptom;nerve supply;Neurosurgeon;novel;novel strategies;open data;Operative Surgical Procedures;Outcome;Parkinson Disease;Participant;Pattern;Performance;Persons;Pharmaceutical Preparations;Phase;Play;pre-clinical;preclinical study;primary outcome;randomized, clinical trials;reconstruction;Research;Role;Safety;Source;STN stimulation;Structure;Structure of subthalamic nucleus;Syndrome;System;Technology;technology development;Testing;Therapeutic;Time;Tissues;tractography;Translating;Visuospatial;Work

PROJECT_TITLE: Neurostimulation of the Nucleus Basalis of Meynert for the cognitive-motor syndrome in Parkinson's disease


NIH_SPENDING_CATS: Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Mutations in mitochondrial aminoacyl-tRNA synthetases (mt-ARSs) cause severe, early-onset, recessive multisystem diseases that often affect the central nervous system. Understanding the complete genetic spectrum of pathogenic mt-ARS variants and their downstream effects on protein and mitochondrial function will provide the necessary foundation to accelerate diagnosis and develop treatments for patients with mt- ARS- related inherited human disease.

PI_NAMEs: DEL GRECO, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Acceleration;Address;Affect;Alkalosis;Alleles;Amino Acids;Amino Acyl-tRNA Synthetases;Aminoacylation;Awareness;Binding;Biological Assay;Biological Process;Biology;Catalytic Domain;cell growth;Cell Line;Cell model;Cell Physiology;Cell Survival;Cells;cellular transduction;Central Nervous System;Classification;clinical heterogeneity;clinical phenotype;Complement;Cytoplasm;Data;design;Diagnosis;Dimerization;Disease;disease phenotype;disease-causing mutation;Doxycycline;early onset;Enzymes;Excision;Foundations;Frequencies;Genetic;Genetic Predisposition to Disease;genetic variant;Genotype;Genus Hippocampus;Goals;Haploid Cells;Hereditary Disease;Heterogeneity;Human;human disease;Human Genome;Hyperuricemia;Impairment;improved;Individual;infancy;Inherited;insight;Kidney Failure;Knowledge;Lead;Libraries;Life;Ligation;loss of function;Maps;Metabolic;Mitochondria;Molecular;Mutation;mutation screening;Neurologic;next generation sequencing;Nuclear;Open Reading Frames;Oxygen Consumption;Paresis;Pathogenicity;Patients;Phenotype;Prognosis;protein function;Proteins;Pulmonary Hypertension;rapid diagnosis;Reporting;Research;Research Training;Role;Science Policy;Serine;Serine-tRNA Ligase;Severities;spasticity;Syndrome;System;Tertiary Protein Structure;Testing;Therapeutic;Tissues;Transfer RNA;Transfer RNA Aminoacylation;Translations;Variant;Yeasts

PROJECT_TITLE: Investigating the Role of Seryl-tRNA Synthetase in Mitochondrial Biology and Human Recessive Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Functional connectivity (FC) changes in the brain are reported to occur in various neurological and psychiatric diseases such as Alzheimer’s disease, depression, and schizophrenia. The direct assessment of FC changes is measured with functional magnetic resonance imaging (fMRI) by looking at the statistical relationship between physiological signals from different brain regions. Important translational advances for robust fMRI-based disease detection can be developed by linking the know changes in FC as observed with fMRI to neuronal changes. This proposal will provide a detailed understanding of how functional connectivity networks as measured with fMRI relate to neural activity and how these networks evolve in response to learning a novel sensorimotor task, paving the way for the creation of more robust fMRI-based disease detection.

PI_NAMEs: MEYER-BAESE, LISA M (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Alzheimer's Disease;Area;awake;Basal Ganglia;Behavioral;Bilateral;blood oxygen level dependent;Blood Vessels;Brain;Brain Diseases;brain health;Brain region;cell type;Cognitive;Complex;Data;Dependence;Detection;Diagnosis;Disease;Distant;Dorsal;excitatory neuron;Frequencies;Functional Magnetic Resonance Imaging;Future;Goals;Head;Health;hemodynamics;Human;Image;insight;Learning;Link;Measurable;Measurement;Measures;Membrane;memory consolidation;Mental Depression;Mental disorders;Methods;Motor;Mus;Nature;Nervous System Disorder;network dysfunction;neural;neural network;Neurons;novel;optical imaging;Outcome;Pathway Analysis;Pattern;Performance;Physiological;Population;Prefrontal Cortex;Process;prognostic;Property;Proteins;Proxy;Publishing;Regulation;Reporting;Research;response;Rest;Schizophrenia;sensor;Sensory;Signal Transduction;Testing;Time;tool;Training;translational impact;voltage;Work

PROJECT_TITLE: Linking membrane voltage dynamics to fMRI measurement of functional connectivity in resting state and task related activities


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Malaria;Neurosciences;Pediatric;Pregnancy;Prevention;Rare Diseases;Vector-Borne Diseases;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Both SARS-CoV-2 and malaria in pregnancy are associated with adverse birth and infant outcomes, but data on long-term effects of gestational SARS-CoV-2 on childhood development in malaria exposed populations are lacking. Leveraging longitudinal clinical data and samples from mother-infant dyads enrolled in two ongoing NIH- funded trials in Busia, Uganda, with high incidence of malaria and SARS-CoV-2, I will evaluate the impact of gestational SARS-CoV-2 on early childhood growth and neurodevelopment, and determine if the effect of gestational SARS-CoV-2 on infant outcomes is mediated by specific maternal inflammatory pathways. This K23 will advance knowledge of the epidemiology and clinical significance of SARS-CoV-2 in pregnancy in a malaria- endemic setting and support my career development in translational research of tropical perinatal infections.

PI_NAMEs: JACOBSON, KAREN BLAKE (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2 year old;2019-nCoV;4 year old;Address;Adverse effects;Africa South of the Sahara;African;Age;Anti-malarials;Birth;career development;Caring;Chemoprevention;Child;Childhood;Clinical;Clinical Data;Clinical Management;Clinical Trials;clinically significant;co-infection;cohort;Cohort Studies;Collaborations;Communicable Diseases;Complex;COVID-19 pandemic;COVID-19 sequelae;cytokine;Data;Data Set;Development;Diagnostic;Discipline of obstetrics;early childhood;Enrollment;Epidemiology;Exclusion;experience;Exposure to;fighting;Funding;Future;geographic population;global health;Goals;Growth;Immune;Immune response;Immunity;Immunology;Impairment;improved;Incidence;Infant;infant outcome;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Interleukin-1;Intervention;Knowledge;Long-Term Effects;Low Birth Weight Infant;Malaria;Mediating;Mentorship;Mothers;Neurocognitive;Neurocognitive Deficit;neurocognitive test;neurodevelopment;Neuropsychology;offspring;Outcome;pathogen;Pathway interactions;Pediatrics;Perinatal Infection;Placebos;Placenta;Plasma;Population;Pregnancy;Pregnant Women;Premature Birth;Prevention trial;Proteomics;Pyrimethamine;Randomized;Regimen;Research;Research Personnel;Resource-limited setting;Resources;Risk;Sampling;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 variant;Serology test;seropositive;Signal Pathway;Sulfadoxine;Testing;therapeutic target;Toddler;Training;Translational Research;translational scientist;Uganda;Underweight;United States National Institutes of Health;Vaccines;vigilance;wasting;Woman

PROJECT_TITLE: Impact of gestational SARS-CoV-2 and maternal inflammation on child growth and neurodevelopment in a malaria-endemic setting

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE We have developed a high-throughput biodosimetry device, the FAST-DOSE (Fluorescent Automated Screening Tool for Dosimetry) assay system to measure radiation-responsive proteins in human blood leukocytes for retrospective estimation of radiation dose. Studies are designed to validate and test the performance of the blood protein biomarker panel to accurately predict absorbed dose after ionizing radiation exposure. We will correlate biomarker expression levels and time kinetics with hematopoietic injury, based on peripheral blood leukocyte counts and bone marrow toxicity in humanized mice.

PI_NAMEs: TURNER, HELEN C (contact)

PROGRAM_OFFICER_NAME: VEDAMONY, MERRILINE M

PROJECT_TERMS: absorption;Academic Medical Centers;Acute;Age;Algorithms;Benchmarking;biodosimetry;Biological Assay;Biological Markers;biomarker identification;biomarker panel;biomarker performance;biomarker validation;Blood;Blood Proteins;Blood specimen;Bone Marrow;Bone Marrow Stem Cell;brca gene;Burn injury;Cell Culture Techniques;Cellular Structures;Color;Computer software;Confidence Intervals;Data;Data Analyses;data exploration;design;Detection;Development;Devices;Diagnostic Equipment;dirty bomb;disease-causing mutation;Dose;dosimetry;Exposure to;FDA approved;Flow Cytometry;Fluorescence;Future;Germ Lines;Hematology;Hematopoietic;Human;humanized mouse;Image;Imagery;Immune;Immunoassay;In Vitro;in vitro testing;in vivo;in-vitro diagnostics;Individual;Industrial Accidents;Inflammation;Inherited;Injury;ionization;Ionizing radiation;irradiation;Kinetics;Laboratories;Leukocytes;Linear Regressions;Lymphocyte;Machine Learning;machine learning algorithm;Mass Screening;mathematical model;Measures;Medical;Medical center;medical countermeasure;micronucleus;Modeling;Mus;Noise;nonhuman primate;nonlinear regression;Nuclear Accidents;Patients;Performance;performance tests;peripheral blood;Persons;Physiological;point of care;Population;predictive modeling;Process;protein biomarkers;Proteins;Protocols documentation;Radiation;Radiation Accidents;Radiation Dose Unit;Radiation exposure;Radiation Tolerance;Reproducibility;Research Design;response;response biomarker;Roentgen Rays;Saliva;Screening procedure;sex;stem;stem cells;Surface Antigens;System;Techniques;Testing;Time;Toxic effect;Trauma;Triage;Uncertainty;Urine;Variant;Vision;White Blood Cell Count procedure

PROJECT_TITLE: Development of FAST-DOSE assay system for the rapid assessment of acute radiation exposure, individual radiosensitivity and injury in victims for a large-scale radiological incident


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Beaverton

ORG_NAME: NAJIT TECHNOLOGIES, INC.

ORG_STATE: OR

PHR: In this proposal, we provide preclinical data demonstrating the safety, immunogenicity, and protective efficacy of an advanced HydroVax vaccine platform and propose to evaluate the safety and immunogenicity of a novel peroxide-inactivated whole-virus chikungunya virus vaccine in a double-blind placebo-controlled Phase 1 clinical trial.

PI_NAMEs: AMANNA, IAN JAMES (contact);SLIFKA, MARK K

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: Address;Adult;Adverse event;Alpha Virus;Americas;Attention;Attenuated;Award;Caribbean region;Case Fatality Rates;cGMP production;chikungunya;chikungunya infection;Chikungunya virus;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Country;Culicidae;Data;Data Analyses;Department of Defense;Development;Disease;Disease Outbreaks;Dose;Double-Blind Method;Ebola;Elderly;Enrollment;Epidemic;FDA approved;Female;Fever;Flavivirus;General Population;Goals;Grant;hemorrhagic fever virus;Hydrogen Peroxide;immune function;Immunize;immunogenic;immunogenicity;India;Individual;Infant;Infection;Infrastructure;International;Investigational Drugs;Investigational New Drug Application;Island;Laboratories;Licensing;Life;male;member;mouse model;Nature;novel;Outcome Measure;Pathology;Peroxides;Persons;Phase;Phase I Clinical Trials;phase I trial;Phase I/II Trial;Placebo Control;Placebos;Polyarthralgias;Population;pre-clinical;Predisposition;primary endpoint;Production;protective efficacy;Protocols documentation;Randomized;Reporting;Research Personnel;Safety;safety assessment;secondary endpoint;Serious Adverse Event;seroconversion;Signs and Symptoms;Societies;stability testing;Technology;Testing;Time;Toxic effect;Toxicology;United States National Institutes of Health;Vaccination;vaccine access;vaccine candidate;vaccine formulation;vaccine platform;vaccine trial;Vaccines;Venezuelan Equine Encephalitis Virus;Veterans;viral transmission;Virus;Vulnerable Populations;West Nile virus;Western Equine Encephalitis Virus

PROJECT_TITLE: A Randomized Phase I Clinical Trial of HydroVax-CHIKV, a Novel Inactivated Chikungunya Virus Vaccine