ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Acute myeloid leukemia (AML) is a leukemia that is incurable and frequently results in death in older adults. Aging and chronic senescence are believed to promote disease progression and relapse. This study proposes to investigate drivers of aging and senescence in the microenvironment of AML with the aim of providing a quantitative measure of senescence in elderly AML patients and identifying novel therapeutic targets that can positively influence the treatment course of this devastating disease.

PI_NAMEs: ABDUL-AZIZ, AMINA  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;adult leukemia;Affect;Age;age acceleration;age related;age related changes;Aging;aging mechanism;Biochemical;Biological Assay;Biology;Bone Marrow;Bone Marrow Examination;cell age;Cell Aging;Cells;Cessation of life;Chemoresistance;chemotherapy;Chronic;Cytometry;Deceleration;Development;Diagnosis;Disease;disease natural history;Disease Outcome;Disease Progression;Disease remission;Disease-Free Survival;drivers of aging;Early treatment;Elderly Acute Myeloblastic Leukemia;Epigenetic age;epigenetic aging;Epigenetic Process;epigenetic regulation;Genes;Genetic Transcription;Genomics;Growth;Hematopoiesis;improved;In Vitro;in vivo Model;Inflammatory;insight;leukemia;Leukemic Cell;Malignant Neoplasms;Measures;Mentors;mesenchymal stromal cell;Metabolic;Methylation;Modeling;Molecular;mortality;neoplastic cell;new therapeutic target;normal aging;novel;novel therapeutics;older adult;Outcome;Patients;Phase;Phenotype;Prevention;Process;Prognosis;Relapse;risk stratification;Role;Sampling;senescence;senescent cell;Supporting Cell;T-Lymphocyte;Techniques;therapeutic target;therapy resistant;Transcriptional Regulation;tumor;tumor microenvironment;Tumor Promotion;Work;young adult

PROJECT_TITLE: Impact of the senescent bone marrow microenvironment in AML biology


ADMINISTERING_IC: DC

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: LOUISVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative. Taste disorders can have detrimental effects on a person's health and quality of life. The underlying mechanisms of these disorders are not understood but may result from disruption of the connections between taste buds and the neurons carrying taste information to the brain. Here, we are exploring the relationship between taste neuron structure, connectivity, and function to elucidate the role of connectivity in taste disorders.

PI_NAMEs: KRIMM, ROBIN FRANCES (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Adult;Anatomy;Axon;Brain;Brain-Derived Neurotrophic Factor;Calcium;cell type;cellular transduction;Characteristics;Chemicals;Citric Acid;Communication;Development;Disease;Epithelium;experimental study;Food;Functional Imaging;functional plasticity;Ganglia;Gene Expression;Genetic;Goals;Health;Hour;Image;in vivo;Individual;insight;intravital imaging;Intrinsic factor;Label;life span;Link;Measurement;Measures;Methods;Morphology;Mus;Nerve Fibers;Neurons;neurotrophic factor;overexpression;Pattern;Peripheral;Persons;Population;preproenkephalin;Process;proenkephalin;Quality of life;Receptor Cell;reconstruction;Regulation;Role;sensory system;Stimulus;Structure;Taste Bud Cell;Taste Buds;Taste Disorders;Taste Perception;taste stimuli;taste system;taste transduction;Temperature;Time;two photon microscopy;Variant;Wild Type Mouse

PROJECT_TITLE: Regulation of taste neuron morphology and function

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Patients and clinicians report feeling insufficient time and rushed in their diagnostic encounters, with both reporting these stresses often compromise the quality of their diagnostic assessments. We have new powerful electronic tools to identify patients seeking diagnostic evaluation of new symptoms, hearing from patients regarding the quality of their diagnostic experience, outcomes, and errors, as well as to measure encounter and note charting time. This project will collect and analyze these data to understand and make recommendations about the time required for high quality safe diagnosis.

PI_NAMEs: SCHIFF, GORDON DAVID (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Time for Better Diagnosis: Measuring Outcomes, Stress and Time proposal (MOST)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The lack of postpartum primary care coordination is a missed opportunity to increase primary care engagement and manage chronic conditions early in life, especially for the >30% of pregnant people who have or are at risk for these conditions. This study aims to increase postpartum primary care engagement, quality, and experience by strengthening postpartum transitions to primary care using a behavioral economics-informed, multi- component intervention integrated into usual inpatient postpartum care. Using a randomized controlled trial and repeated outcome assessments through administrative and survey data, this study will generate rigorous, actionable evidence to ensure primary care coordination becomes standard postpartum care practice, potentially catalyzing sustained primary care engagement throughout life.

PI_NAMEs: CLAPP, MARK ALLEN (contact);COHEN, JESSICA LEE

PROGRAM_OFFICER_NAME: EDEN, AIMEE

PROJECT_TITLE: Bridges to Primary Care: Transforming Postpartum Primary Care Coordination for People with Chronic Conditions

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Errors in the process of distributing chromosomes during cell division is the major cause of birth defects and contributes to tumor progression. The chromosomes are moved by microscopic cables. This project will explore how cells are able to attach chromosomes to these cables without errors, to assure that each daughter cell receives a correct chromosome set.

PI_NAMEs: DAWSON, DEAN S (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: addiction;Aneuploidy;Behavior;Biological Models;Biology;biophysical properties;Cell Cycle;Cell division;cell type;Cells;Centromere;chromosomal location;chromosome movement;Chromosome Segregation;Chromosomes;Congenital Abnormality;daughter cell;Emerging Technologies;Ensure;experimental study;Genetic Screening;Germ Cells;Goals;Infertility;insight;Kinetochores;Knowledge;Link;Mediating;Meiosis;Microscopic;Microtubules;Mitosis;Modeling;Optic Chiasm;parent grant;Pathway interactions;Phosphotransferases;Play;Polyploid Cells;Positioning Attribute;Process;Prometaphase;Role;Saccharomycetales;segregation;Side;Somatic Cell;success;Testing;transmission process;Tumor Cell Line;tumor progression;Yeasts

PROJECT_TITLE: Centromere behaviors that promote proper chromosome segregation in meiosis and mitosis


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Interstitial Cystitis;Neurosciences;Pain Research;Precision Medicine;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: This proposal aligns with the objectives of RFA-NS-24-021 by developing an innovative model of inter-individual differences of lived comorbid menstrual and pelvic pain, incorporating the interplay of inflammatory and neurobiological mechanisms, as well as psychosocial factors with a multidisciplinary team that will lead to evidenced based precision medicine. Focusing on mechanistic insights into uterine pain associated with prevalent gynecological conditions in women, this project aligns NICHD mission that women suffer no harmful effects from reproductive processes and that all children have the chance to achieve their full potential for healthy and productive lives, free from disease or disability, and to ensure the health, productivity, independence and wellbeing of all people.

PI_NAMEs: HELLMAN, KEVIN  (contact)

PROGRAM_OFFICER_NAME: AHN, HELENA HYESOOK

PROJECT_TERMS: Accounting;active method;Acute;Address;advanced disease;Affect;Aftercare;Animal Model;Anti-Inflammatory Agents;Bladder;bladder pain;Brain;causal model;Central Nervous System;central sensitization;Child;chronic pain;chronic pelvic pain;Clinical Trials;Collection;Colon;Communities;comorbidity;Coupled;cytokine;Data;density;design;Deterioration;Development;diagnostic criteria;diaries;disability;Disease;Disease Progression;Distress;dosage;Dysmenorrhea;Electric Stimulation;Electroencephalography;Electronics;Endometrial;endometriosis;Endometrium;Ensure;Equation;Esthesia;evidence base;Future;Goals;Gonadal Steroid Hormones;Gynecologic;Health;Heterogeneity;high risk;High Risk Woman;Human;Hypersensitivity;improved;Individual;Individual Differences;individual response;Inflammation;Inflammatory;innovation;insight;inter-individual variation;Interstitial Cystitis;Irritable Bowel Syndrome;Masks;Measures;Mechanics;Mediator;meetings;Mission;Modeling;Moods;multidisciplinary;multimodality;Naproxen;National Institute of Child Health and Human Development;Nerve;neural;neurobiological mechanism;Neurologic;neuromechanism;Neurons;Nociception;Non-Steroidal Anti-Inflammatory Agents;novel;Odds Ratio;Organ;Pain;pain chronification;Pain Disorder;Pain Free;Pain management;pain model;pain reduction;pain relief;Participant;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Pelvic Pain;Pelvis;perimenstrual;Peripheral;Personal Satisfaction;Persons;pharmacologic;Phenotype;Physiology;Placebos;precision medicine;Predictive Factor;Prevalence;prevent;Prevention;Preventive treatment;Productivity;programs;prophylactic;prospective;psychosocial;Psychosocial Factor;Questionnaires;Randomized;Randomized, Controlled Trials;Reproductive Process;response;Risk;Risk Factors;risk prediction;Role;Sampling;Sensory;sensory mechanism;Severities;Sleep;Spinal;Spinal Cord;Standardization;statistics;Stress;Structure;Subgroup;Symptoms;targeted treatment;Testing;treatment duration;Treatment Protocols;Uterus;Variant;Visceral;Visceral pain;Water;Woman;Women's study;Women's trial;Work

PROJECT_TITLE: Targeting Interindividual Variability in NSAID Responses to Mitigate Chronic Pelvic Pain Risk in Dysmenorrhea

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-A (57)]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Plasma concentrations of biomarkers of Alzheimer's Disease and Related Dementias (ADRD) are correlated with their levels in the cerebrospinal fluid (CSF) and with amyloid and tau burden in the brain on PET scans. This administrative supplement to the SWAN Aging U19 aims to demonstrate the utility of blood-based biomarkers measured in midlife in predicting cognitive functioning and future cognitive decline in Black and White women. These results would support early identification of sub-clinical ADRD pathology in midlife and early intervention to stave off ADRD before potentially irreversible damage has set in.

PI_NAMEs: BROOKS, MARIA MORI (contact);KARLAMANGLA, ARUN S;MCCONNELL, DANIEL S

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Address;Administrative Supplement;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Axon;Behavioral;Biological;Biological Assay;Biological Markers;Black Populations;Black race;black women;Blood;Blood specimen;Blood Vessels;blood-based biomarker;Brain;Brain-Derived Neurotrophic Factor;cardiovascular risk factor;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Data;Dementia;dietary;Disease Progression;early detection biomarkers;Early identification;Early Intervention;Episodic memory;Exposure to;Financial Hardship;follow-up;Follow-Up Studies;Freezing;Frontotemporal Dementia;Future;Glial Fibrillary Acidic Protein;Growth;Health;healthy lifestyle;high risk;Hippocampus;human old age (65+);Impaired cognition;Intervention;knowledge base;Lewy Body Disease;Light;Longitudinal Studies;Measures;Memory;middle age;Midlife women;mild cognitive impairment;Modification;multi-ethnic;Nerve Degeneration;neurofilament;neurogenesis;Neurons;older adult;Participant;Pathology;Performance;Perimenopause;Physical activity;Plasma;Positioning Attribute;Positron-Emission Tomography;processing speed;prognostic value;prospective;protein biomarkers;Race;racial disparity;Risk;Serum;Short-Term Memory;Speed;Study of Women's Health Across the Nation;synergism;tau Proteins;tau-1;Temporal Lobe;Testing;Time;Translating;vascular contributions;Vascular Dementia;verbal;Visit;White Women;Woman;Women's cohort

PROJECT_TITLE: The Study of Women's Health Across the Nation (SWAN): The Impact of Midlife and the Menopause Transition on Health and Functioning in Early Old Age


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: 10-15% of the US population carries a label of penicillin allergy, leading to use of less effective antibiotics, increased treatment failures and toxicities, and increased likelihood of acquiring drug resistant and opportunistic infections. We have demonstrated the success of point of care penicillin allergy risk assessment and delabeling efforts to target low-risk allergy labels. This proposal will assess the barriers and facilitators of penicillin allergy assessment and testing amongst key outpatients who stand to benefit, validate a novel patient centered approach to penicillin allergy risk assessment, and implement penicillin allergy risk assessment into routine pre-surgical care.

PI_NAMEs: STONE, COSBY A (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Adapting and Implementing Risk-Stratified Penicillin Allergy Evaluation in Key Outpatient Settings


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: BIRMINGHAM

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Glaucoma is a blinding eye disease increasingly common in older adults. Since it is largely irreversible and often diagnosed late in the disease course, it is essential to develop novel practical health care models to improve the ability to detect occult glaucoma and direct appropriate cases towards medical treatment. This project will determine the feasibility of a low-cost glaucoma screening program conducted within Federal Qualified Health Centers that serve low income regions.

PI_NAMEs: GIRKIN, CHRISTOPHER ANTHONY;OWSLEY, CYNTHIA  (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: RFA-DP-24-081 Implementing AI-based Glaucoma Screening within Federally Qualified Health Centers

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (02)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Dysregulation of melanocytes or melanocyte stem cells leads to diseases that significantly affect an individual's quality of life, ranging from fatal cancers to hyper- and hypo-pigmentation disorders. The goal of this project is to better understand the biology and pathology of these cells through studying the function of a new uncharacterized gene involved. Unlocking the mechanism of this gene will provide new therapeutic targets for manipulating these cells to treat vitiligo, hyper-pigmentation disorders, and melanoma.

PI_NAMEs: SHELLMAN, YIQUN G (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Affect;Aging;Binding;Biochemical;Biological;Biological Process;Biology;Cancer Biology;Cell Cycle Progression;Cell Differentiation process;Cell Lineage;Cell Maintenance;Cell Physiology;Cells;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Disease;gene correction;Genes;Genetic;Goals;Hair;Hyperpigmentation;Hypopigmentation;Impairment;In Vitro;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Inherited;insight;interest;Kinetics;Knockout Mice;Life;Literature;Maintenance;Malignant Neoplasms;Measurable;Mediating;melanocyte;Melanoma;Mission;Mitotic;Mitotic spindle;Molecular;mouse model;Mus;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural regeneration;new therapeutic target;novel;novel strategies;Outcome;Pathologic;Pathology;Patients;Pattern;Phenotype;Pigmentation Disorders;Pigmentation physiologic function;Play;Population;premature;Preventive;Proliferating;Proteins;Quality of life;Regenerative Medicine;Regulation;Research;Role;stem cell biology;stem cell model;stem cells;Structure;Study models;Subcutaneous Tissue;Tankyrase;Testing;Therapeutic;three-dimensional modeling;TNKS gene;tool;Ultraviolet Rays;Variant;Vitiligo;Work;young adult

PROJECT_TITLE: Study of melanocyte lineage through SASH1 and associated proteins

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: SAINT LOUIS UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  The proposed research is of high significance because it defines the functional mechanism of a major sphingosine-1-phosphate (S1P) transporter Spns2, a bioactive lipid important to regulating the growth, survival and migration of mammalian cells with profound proangiogenic effects. The project is relevant to public health because it will lay the foundation for the development of new therapeutic strategies for diseases associated with S1P signaling and to target Spns2 as a potential immunosuppressant. An innovative aspect of this proposal is the application of a suite of integrated biophysical methods to characterize the transport and regulatory mechanisms of Spns transporters.

PI_NAMEs: DASTVAN, REZA  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: biophysical techniques;Cations;Cellular Membrane;Coupled;Defect;Development;Disease;Drug Targeting;Electrons;Endothelial Cells;extracellular;Family;Family member;flexibility;Foundations;Goals;Growth;Homologous Gene;Human;Immune system;Immunosuppressive Agents;Immunotherapy;Impairment;innovation;Inorganic Phosphate Transporter;Ligands;Lipid Bilayers;Lipids;Lymphocyte;Malignant Neoplasms;Mammalian Cell;Maps;Mediating;migration;Molecular Conformation;molecular dynamics;molecular modeling;Mus;nanoscale;Neoplasm Metastasis;novel therapeutic intervention;Physiologic pulse;Physiological;Play;prevent;Proteins;Protons;Public Health;Regulation;Research;Resolution;restraint;Role;Signal Transduction;Spectrum Analysis;Sphingolipids;sphingosine 1-phosphate;Structure;Techniques;Therapeutic;therapeutic target;tumor

PROJECT_TITLE: Structural dynamics of sphingosine-1-phosphate transporters as key therapeutic targets for immune system modulation and cancer


ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: The proposed research is relevant to public health because it will develop drug delivery vehicles that can modulate the metabolism of immune cells and generate effective immune responses to prevent or reverse autoimmune disorder. This project is highly relevant to the NIH’s mission because it will provide mechanistic understanding of the role of metabolic reprogramming of dendritic cells, and T helper cells in rheumatoid arthritis progression.

PI_NAMEs: ACHARYA, ABHINAV  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adaptive Immune System;Aftercare;alpha ketoglutarate;Animal Model;Animals;Ankle;ankle joint;Antigen Presentation;antigen test;Antigen-Presenting Cells;Antigens;appropriate dose;Arthritis;Autoantigens;Autoimmune Diseases;autoreactive T cell;Biocompatible Materials;biodegradable polymer;Biological Assay;Biological Products;cancer clinical trial;Cattle;CCL22 gene;CD86 gene;Cell Physiology;Cell Separation;Cells;Cervical;Chemotaxis;Chondrocytes;Citric Acid Cycle;Clinical;Clinical Trials;Collagen;Collagen Arthritis;comparison control;cytokine;Data;DBA/1J Mouse;delivery vehicle;Dendritic cell activation;Dendritic Cell Vaccine;Dendritic Cells;Disease;Disease remission;Dose;Drug Delivery Systems;Encapsulated;Enzymes;experimental study;extracellular;fatty acid oxidation;Fibroblasts;Flow Cytometry;Formulation;Foundations;Frequencies;Future;Genus Hippocampus;Glucosephosphate Isomerase;Glycolysis;Glycolysis Inhibition;Goals;Helper-Inducer T-Lymphocyte;Homeostasis;Human;Immune;Immune response;Immunohistochemistry;immunoregulation;Immunosuppression;Immunosuppressive Agents;improved;In Vitro;in vivo;Inflammation;inflammatory marker;inhibitor;Innate Immune System;interest;Joints;K/BxN model;Kidney;Kinetics;Knee;Kynurenine;Lead;Lethal Dose 50;Liver;Lung;lymph nodes;lymphoid organ;Lymphoid Tissue;Macrophage;Manuscripts;Maximum Tolerated Dose;Measures;Mediating;Membrane Proteins;Memory;Metabolic;Metabolism;metabolomics;meter;Mission;Modeling;Monitor;Mus;Mutation;novel;Organ;Oxygen Consumption;particle;Pathway interactions;Peripheral;Phagocytosis;Pharmaceutical Preparations;Phenotype;Physiological;Play;Polymers;PPBP gene;prevent;Prevention;Process;Production;Protocols documentation;Provider;Public Health;Regulatory T-Lymphocyte;Research;Research Project Grants;response;Rheumatoid Arthritis;Role;Safety;Saline;scale up;Serum;subcutaneous;Symptoms;T cell anergy;T cell response;T memory cell;T-Lymphocyte;technology development;Testing;Thick;Tissues;Toxic effect;transcriptome sequencing;Tryptophan;United States National Institutes of Health;Weight Gain

PROJECT_TITLE: Local immunometabolism modulating biomaterials for immunosuppressive applications

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: Project Narrative  Cardiovascular magnetic resonance imaging (CMR) is routinely used in the clinical management of cardiovascular disease and is the standard method for the assessment of cardiac function and myocardial tissue properties. However, B0 inhomogeneity represents the biggest challenge for clinical CMR on 3.0T because it prevents the consistent application of steady-state free precession (SSFP), which revolutionized CMR at 1.5T. This project will apply a novel unified shim-RF coil technique to overcome the primary limitation and enable robust SSFP CMR on 3.0T, which has the potential to have a major impact in accelerating the clinical adoption of 3.0T CMR.

PI_NAMEs: SPINCEMAILLE, PASCAL  (contact);YANG, HSIN-JUNG

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Abdomen;Acceleration;Adoption;Air;Angiography;Breathing;Cardiac;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Chest;Clinical;Clinical Management;Compensation;Coronary;Development;Echo-Planar Imaging;Feedback;Frequencies;Goals;healthy volunteer;Heart;heart function;human subject;Image;Imaging Techniques;improved;innovation;Lung;Magnetic Resonance;Magnetic Resonance Imaging;Magnetism;Maps;Methods;Morphologic artifacts;Motion;multitask;Myocardial tissue;Noise;novel;Organ;Penetration;Performance;Predisposition;prevent;Property;Protocols documentation;Resolution;Respiration;respiratory;RF coil;Safety;Scanning;Signal Transduction;Source;System;Techniques;technology validation;Time;Tissues;Variant;Vendor;Vertebral column;Work

PROJECT_TITLE: SSFP Cardiovascular MR Imaging on 3.0T Using Unified-Coil Local Shimming


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Genetics;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE Helicobacter pylori infect the human stomach of 50% of the world’s population where it can cause mild inflammation, ulcer disease and even gastric cancer, depending in part on the genetic diversity of the infecting strain. In this project we study the genes and mechanisms contributing to chronic colonization to identify the mediators of persistent infection. Our studies of genetic variation during stomach infection will show how these mediators adapt during the chronic inflammation that leads to severe disease (cancer).

PI_NAMEs: SALAMA, NINA  (contact)

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Acids;Adenocarcinoma;Adoptive Transfer;Animals;Atrophic Gastritis;Attenuated;Bone Marrow;carcinogenesis;cell envelope;Cell Shape;Cells;chemokine;Chemotaxis;Chronic;chronic infection;Clinical;Clinical Data;Coculture Techniques;Collection;Data;Disease;Environment;Epithelial Cells;Epithelium;Event;Excision;Flow Cytometry;Funding;Gastric Adenocarcinoma;Gastric Metaplasia;Gastric mucosa;gastric organoids;Gastric Parietal Cells;Gene Expression;Genes;Genetic;genetic analysis;Genetic Recombination;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced carcinogenesis;Host Defense;Human;Immune;immune activation;immunoregulation;In Vitro;in vivo;Individual;Infection;Infiltration;Inflammation;Inflammatory;Intestinal Intraepithelial Neoplasia;Intestinal Metaplasia;Leukocytes;Lymphoid Tissue;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Mediator;Membrane Proteins;Metaplasia;Modeling;Molecular;Monitor;Motility;mouse model;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;neoplastic;neutrophil;novel;Organism;pathogen;Pathogenicity;Pathology;Peptic Ulcer;Phenotype;Population;population based;receptor;recruit;response;Risk;Role;Sampling;Sequence Analysis;Signal Pathway;Signal Transduction;spasmolytic polypeptide;Stomach;System;Testing;Tissues;Toxin;transmission process;tumor-immune system interactions;Type IV Secretion System Pathway;Ulcer;Variant;whole genome;Work

PROJECT_TITLE: Genetic requirements of Helicobacter pylori infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Repeat-associated non-AUG (RAN) translation of C9orf72 mRNA can generate toxic dipeptide repeat proteins that accumulate within aggregates in the brains of affected individuals and contribute to Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). This proposal will use cryo-electron microscopy and biochemical approaches to study RAN translation at high resolution, including in neurons.

PI_NAMEs: BRITO QUERIDO, JAILSON  (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 5' Untranslated Regions;Address;Affect;Affinity;Bacterial Toxins;Binding;Biochemical;Biological;Biological Assay;Biological Models;Biology;Brain;C9ORF72;Cell Separation;Cells;Codon Nucleotides;Complex;crosslink;Cryoelectron Microscopy;Dipeptides;Disease;Endoribonucleases;Environment;eukaryotic initiation factor-5B;Eukaryotic Initiation Factors;frontotemporal lobar dementia amyotrophic lateral sclerosis;Generations;Genes;genetic approach;genetic regulatory protein;Guanosine Triphosphate Phosphohydrolases;Human;In Vitro;Individual;Induced pluripotent stem cell derived neurons;Initiator Codon;innovation;insight;Introns;Location;Maps;Mass Spectrum Analysis;Medical;Messenger RNA;Modeling;Molecular;mRNA Translation;mutant;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurons;new therapeutic target;novel;Nucleotides;Peptide Initiation Factors;Process;protein aggregation;Proteins;Proteomics;reconstitution;recruit;Regulation;Research;Research Personnel;Resolution;Ribosomes;RNA;Role;Scanning;Site;Structure;System;tool;Transfection;translation factor;Translation Initiation;Translational Regulation;Translations;Visualization;Work

PROJECT_TITLE: Deciphering the structural basis of repeat-associated non-AUG (RAN) translation in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infectious Diseases;Lung;Microbiome;Pneumonia;Pneumonia and Influenza

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE  Hypervirulent Klebsiella pneumoniae (hvKP) is an evolving pathotype that causes increased morbidity and mortality in healthy individuals within a community setting. This project will examine bacterial mechanisms, host-barrier efficacy, changes in bacterial populations, and identify bacterial genetic determinants that enable hvKP to colonize and disseminate from the gastrointestinal tract causing disease. Completion of the proposed work will aid in broadening our understanding of hvKP pathogenesis and identify potential therapeutic targets.

PI_NAMEs: ZAFAR, MUHAMMAD AMMAR (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: aerobactin;Affect;Bacterial Genes;bacterial genetics;Bacterial Pneumonia;Bar Codes;Biological;burden of illness;Cell Culture Techniques;Cellular Membrane;chelation;colonization resistance;combat;community setting;Community-Acquired Infections;Defect;Diet;Disease;drug resistant pathogen;Effectiveness;Endophthalmitis;enteric pathogen;Enterobactin;epidemiology study;Ethanolamines;experimental study;Feces;fitness;gastrointestinal;Gastrointestinal tract structure;Gene Expression;gene product;Genes;Genetic;Genetic Determinism;genomic locus;Goals;Gram-Negative Bacteria;gut colonization;gut microbiota;High-Throughput Nucleotide Sequencing;host colonization;Hour;Immunocompetent;In Vitro;Individual;Infection;insight;intestinal barrier;intestinal epithelium;Intestines;Iron;Klebsiella pneumoniae;Libraries;Maps;Mediating;Meningitis;Metabolic Pathway;Metabolism;metagenomic sequencing;microbial;microbiome components;microbiota;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;mucoid;Mucous Membrane;Multi-Drug Resistance;Mus;mutant;Nosocomial Infections;novel;Nutrient;Operon;Oral;Oropharyngeal;parent grant;parent project;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phenotype;Plasmids;Pneumonia;Polysaccharides;Population;potency testing;Prevention;Process;Pyogenic Liver Abscess;RNA;Role;Route;Siderophores;Site;Source;Splenic Abscess;Structure;Surface;System;Testing;therapeutic target;transmission process;transposon sequencing;Urinary tract infection;Virulence;Virulence Factors;Virulent;Work;yersiniabactin

PROJECT_TITLE: Mechanisms of hypervirulent Klebsiella pneumoniae gastrointestinal colonization and dissemination

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(90)]


NIH_SPENDING_CATS: Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE  This project will improve the early recognition of physical abuse in infants, to improve the chance that they can be protected from ongoing violence, permanent injury, and death. Despite decades of education, awareness-building, screening by nurses, and other efforts, abuse is often missed in the youngest children who cannot speak for themselves. This project will test a program of automated screening by computers that can analyze data from the medical chart in real-time to alert healthcare providers to findings that should raise concern for abuse, but which are often missed.

PI_NAMEs: LINDBERG, DANIEL M (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Accident and Emergency department;Adopted;Affect;Awareness;Behavior;Cessation of life;Child;child physical abuse;child protective service;Childhood;Clinical;clinical care;Computers;Contusions;Data;Diagnosis;Disparity;Education;Electronic Health Record;Emergency Care;Emergency department visit;Equity;ethnic disparity;Ethnic Origin;Evaluation;Foundations;Fracture;Frequencies;Goals;Guidelines;health care settings;Health Care Visit;Health Personnel;Healthcare;Healthcare Systems;high risk;Human;improved;Infant;Injury;innovation;Intervention;Link;Manuals;Measures;Medical;medical specialties;Methods;Minor;natural language;Natural Language Processing;Nurses;Oral;Outcome;Patient-Focused Outcomes;physical abuse;Positioning Attribute;prevent;Professional Organizations;programs;prospective;Public Health;Race;racial disparity;rare condition;Recurrence;Reporting;Research;Resources;Risk;routine screening;screening;Screening procedure;Services;Specificity;System;tertiary prevention;Testing;Time;tool;treatment as usual;urgent care;Validation;vigilance;Violence;Visit

PROJECT_TITLE: Natural Language Screening to Improve Early Recognition of Child Physical Abuse in Emergency Care Settings

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

PHR: Project Narrative The proposed research is relevant to public health because it develops technologies to reprogram metabolism of immune cells, and develop immunotherapies using these technologies in combination with metabolic inhibitors. This project is relevant to the NIH's mission because it will provide mechanistic understanding of the role of metabolism in development/progression of melanoma, and the effect of reprograming of energy metabolic pathways used by the cancer and immune cells for tumor treatment.

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Adjuvant;Adoptive Transfer;Antigen-Presenting Cells;Antigens;appropriate dose;Biocompatible Materials;Biological Assay;Bone Marrow;BRAF gene;cancer cell;cancer type;Cancer Vaccines;Carbon;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Citric Acid Cycle;Collecting Cell;Combination immunotherapy;Complex;Contralateral;cytotoxic;Cytotoxic T-Lymphocytes;Data;Dendritic cell activation;Dendritic Cells;Development;Dopachrome isomerase;Dose;draining lymph node;ethylene glycol;exhaust;experimental study;extracellular;Formulation;Frequencies;Fructose;Future;GATA3 gene;Generations;Genus Hippocampus;Glutaminase;Glycolysis;Glycolysis Inhibition;Glycolysis Pathway;Goals;Growth;Helper-Inducer T-Lymphocyte;Human;Immune;Immunocompetent;Immunohistochemistry;Immunotherapy;In Vitro;in vivo;inhibitor;inorganic phosphate;Intravenous;Kidney;Kinetics;Liver;long term memory;lymph nodes;Lysine;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Maximum Tolerated Dose;Measures;Melanoma;Melanoma Tumor;Metabolic;metabolic fitness;Metabolic Pathway;Metabolism;Mission;Mitochondria;mitochondrial fitness;Modeling;mouse model;Mus;mutant;nanoparticle;neoplasm immunotherapy;NF-kappa B;novel;Organ;Oxygen Consumption;particle;Pathway interactions;Peptides;Phagocytosis;Poly I-C;Polymers;prevent;Production;programmed cell death protein 1;programs;Proliferating;Public Health;Publishing;Reaction;Reactive Oxygen Species;Research;Research Project Grants;Respiration;response;Role;Safety;scale up;Sorting;Stress Tests;subcutaneous;Succinates;T cell response;T memory cell;T-Lymphocyte;Technology;Testing;Toxic effect;Treatment Protocols;tumor;Tumor Burden;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Vaccine Design;vaccine efficacy;vaccine response;Vaccine Therapy;Vaccines;Vertebral column;Work

PROJECT_TITLE: Biomaterials-based metabolic rescue of dendritic cells for vaccine design


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Kidney Disease

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative  Many patients with kidney failure on dialysis experience abnormal bone metabolism, placing them at higher risk for death, cardiovascular events, and fractures, and may necessitate removal of the parathyroid glands. This condition is treated with a class of medications called calcimimetics, which before 2018, over 20% of dialysis patients could not access because of how they were paid for through Medicare. This project will evaluate a) whether a Medicare policy change enhanced access to these expensive medications and b) whether this translated to improvements in important patient outcomes, with broader implications for understanding how health policies have the potential to influence disease burden in dialysis patients.

PI_NAMEs: CALDWELL, JILLIAN SCOTT (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Award;beneficiary;bone;bone metabolism;bundled payment;burden of illness;California;Cardiovascular system;career;Career Mobility;Characteristics;cinacalcet;Clinical;Clinical effectiveness;Collaborations;comparative effectiveness;Complex;Data;Death Rate;Dialysis patients;Dialysis procedure;Disease;Drug Prescriptions;econometrics;End stage renal failure;Event;Excision;experience;FDA approved;Fee-for-Service Plans;Fellowship;Fracture;Geographic Locations;Goals;Grant;Health Policy;Health Services;Health Services Research;Heterogeneity;high risk;Hormone secretion;improved;improved outcome;Incentives;Individual;Information Systems;insight;Intervention;Intravenous;K-Series Research Career Programs;Kidney;Kidney Failure;Knowledge;Maintenance;Medicare;Medicare claim;Medicare Part B;Mentorship;Metabolism;Methodology;Methods;Minerals;Morbidity - disease rate;mortality;mortality risk;Natural experiment;Nephrology;novel;Oral;Outcome;Parathyroid gland;Parathyroidectomy;Patient-Focused Outcomes;Patients;Pattern;payment;Pharmaceutical Preparations;Policies;Population;Postdoctoral Fellow;PTH gene;Randomized, Controlled Trials;Research;Research Personnel;secondary analysis;Secondary Hyperparathyroidism;Secondary to;Selection Bias;skills;success;Surrogate Endpoint;Techniques;Training;Translating;Underinsured;United States;Universities;Work

PROJECT_TITLE: Incentive Payments and Practice Patterns in Dialysis: The Case of Calcimimetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-B (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: HOUGHTON

ORG_DEPT: CHEMISTRY

ORG_NAME: MICHIGAN TECHNOLOGICAL UNIVERSITY

PHR: Project Narrative is the same as that for the parent award (2R15GM109288-03), and should not be submitted for this Administrative Supplement application according to PA-20-272.

PI_NAMEs: FANG, SHIYUE  (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TITLE: Synthesis of Sensitive Epitranscriptomically Modified RNAs


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative. This project employs wearable biosensors and artificial intelligence to advance understanding and prediction of heavy drinking episodes during initial recovery from alcohol use disorder. It focuses on developing real-time predictive models and identifying neuroclinical and physiological mechanisms that influence recovery dynamics. Integrating high-density sensor data, machine learning, and intensive longitudinal research, the project aims to create personalized, timely interventions for individuals in early recovery stages.

PI_NAMEs: MCKEE, SHERRY ANN (contact);ROBERTS, WALTER MCRAINEY

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Abstinence;addiction;Address;Adult;alcohol abuse therapy;Alcohol consumption;alcohol craving;alcohol use disorder;Alcohols;Ambulatory Care Facilities;Anhedonia;Artificial Intelligence;artificial intelligence method;Behavior;Behavior assessment;Behavioral;behavioral phenotyping;biopsychosocial;Biosensor;Clinical;cohort;Collaborations;collaborative approach;Communities;Complex;Computing Methodologies;convolutional neural network;craving;cue reactivity;Data;Data Analyses;data integration;Data Set;data streams;density;design;Development;Devices;drinking;Electrocardiogram;Emotional;Ensure;Executive Dysfunction;experience;explainable artificial intelligence;explainable machine learning;Face;Funding;Future;Goals;Health;Health Technology;heart rate variability;Heavy Drinking;Impairment;improved;incentive salience;Individual;Individual Differences;innovation;insight;Interruption;Intervention;Investigation;Knowledge;Laboratories;Literature;Machine Learning;machine learning algorithm;markov model;Measurement;Measures;Methodology;mHealth;mild cognitive impairment;mobile sensing;Modeling;Monitor;Nature;negative mood;neurophysiology;novel;Outcome;Participant;Patient Self-Report;Patients;Pattern;Periodicals;Persons;Physiological;Physiology;predictive modeling;Probability;Process;Psychophysiology;Reaction;real time monitoring;Records;Recovery;recruit;remote intervention;Research;Research Design;Research Project Grants;Risk;risk prediction model;Role;sensor;Series;Sleep disturbances;Symptoms;System;Techniques;Technology;Time;tool;Translating;treatment research;wearable data;wearable device;wearable sensor technology

PROJECT_TITLE: Characterizing initial recovery from alcohol use disorder and predicting heavy drinking using mobile biosensors

STUDY_SECTION: AA

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Antenatal care commonly fails to meet the needs of low-income pregnant individuals, who are at increased risk for adverse pregnancy outcomes due to effects of racism, poverty, and inadequate attention to social determinants of health. Addressing the pervasive disparities in maternal and neonatal health requires innovative, sustainable, and more effective models of antenatal care delivery; one strategy may be patient navigation, a barrier-focused, longitudinal, patient-centered intervention that offers support for a defined set of health services. The Partnering with Antenatal Navigators to Transform Health in Pregnancy (PATH) proposal to evaluate a novel, comprehensive antenatal patient navigation program among low-income pregnant people has the potential to meaningfully improve maternal and neonatal health and reduce disparities in maternal morbidity and mortality.

PI_NAMEs: YEE, LYNN M (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Administrator;Admission activity;adverse maternal outcomes;adverse outcome;adverse pregnancy outcome;Affect;Age;antenatal;antenatal care;Attention;Birth;Black race;care delivery;Caring;Child health care;Chronic Disease;Clinical;Collection;Communication;Development;Discipline of obstetrics;Disparity;Disparity population;disparity reduction;Dissemination and Implementation;economic disparity;efficacy evaluation;efficacy testing;Elements;Enrollment;Equity;ethnic diversity;Ethnic Origin;Exercise;experience;Exposure to;Feedback;Fetal Growth;Funding;Future;Gestational Age;Goals;Health;health care availability;health care service utilization;health disparity;health equity;health outcome disparity;Health Services;Health Services Accessibility;Health Status;Health system;Healthcare;Healthcare Systems;Hispanic;hospital utilization;Hospitals;Household;Hypertension;implementation science;improved;Incidence;Income;indexing;Indigenous;Individual;Inequity;innovation;Intensive Care Units;Intervention;Interview;Length of Stay;Low Birth Weight Infant;Low income;Low Income Population;Maps;marginalized population;Maternal Age;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;Medical;Medical Records;meetings;Methods;Minority Groups;Mission;Modeling;mortality;motherhood;Neonatal;neonatal health;neonatal outcome;novel;Nulliparity;obstetric outcomes;Outcome;Participant;patient navigation;patient oriented;Patient Outcomes Assessments;Patient Self-Report;Patients;pediatric health outcomes;Perinatal;perinatal health;Perinatal mortality demographics;perinatal outcomes;Persons;postpartum care;Postpartum Hemorrhage;Postpartum Period;Poverty;Pregnancy;pregnancy disorder;pregnant;premature;Premature Birth;Prenatal care;Preparation;Prevention strategy;Process;programs;Public Health;public health insurance;Quality of life;Race;racial diversity;racism;Randomized;randomized trial;recruit;remediation;Risk;satisfaction;Self Efficacy;Service delivery model;Services;severe maternal morbidity;Shapes;Small for Gestational Age Infant;social;social health determinants;socioeconomic disadvantage;Stress;Surveys;Testing;Training;treatment as usual;United States;United States National Institutes of Health;uptake;Visit

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE The system comprising the bacterium Escherichia coli and its virus, bacteriophage lambda, serves as a simple paradigm for the way gene regulation drives the choice between alternative cellular fates. The outcome of the proposed work will be a predictive, quantitative description of gene regulation and fate choice in the system, at the single-cell level. The conceptual and experimental tools developed in this work will further our understanding of how gene regulation drives cell-fate choices in higher systems, and ultimately, in the context of human health and disease.

PI_NAMEs: GOLDING, IDO  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Awareness;Bacteria;Bacteriophage lambda;Bacteriophages;Behavior;behavior prediction;Biological;Biology;Biophysics;cell behavior;Cell Death;Cell Differentiation process;Cell Physiology;Cells;Complex;Cytolysis;Disease;Embryo;emerging antibiotic resistance;Environment;Escherichia coli;Escherichia coli Infections;Event;Exhibits;Gene Expression;Gene Expression Regulation;Genetic;Goals;Health;Heterogeneity;Human;Image;Individual;Individuality;Infection;Lysogeny;Maps;Modeling;Molecular;Noise;Organism;Outcome;Phenotype;Process;Property;Proteins;Research;Role;Signal Transduction;single molecule;Statistical Distributions;success;System;tool;Viral;Virus;Work

PROJECT_TITLE: ILLUMINATING CELLULAR INDIVIDUALITY THROUGH BACTERIOPHAGE INFECTION

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_NAME: IIT RESEARCH INSTITUTE

PI_NAMEs: MCCORMICK, DAVID L. (contact)

PROJECT_TERMS: Award;Clinic;Contracts;Development;drug development;Evaluation;Malignant Neoplasms;meetings;pharmacologic;Pharmacology and Toxicology;pre-clinical;Preclinical Drug Development;Preventive;Program Development;programs;Resources;Services;Structure;Support Contracts;Testing;Toxicology;vaccine development

PROJECT_TITLE: Contract Orientation and Kickoff Meeting


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Narrative This mixed-methods study will examine the impact of state-level telehealth policies on perinatal behavioral health outcomes (e.g., emergency department visits, overdoses, and suicide) and maternal-infant outcomes (e.g., maternal morbidity, preterm delivery), overall and among historically marginalized populations. We will use event-time modeling, a quasi-experimental approach, to estimate the relationship between telehealth policies of interest and key outcomes, with a focus on identifying inequities by race/ethnicity, rural residence, and disability status; then apply the Consolidated Framework for Implementation Research in a series of in- depth interviews with patients and providers to explain the quantitative findings through an examination of factors that influence telehealth policy implementation and associated health outcomes. Study findings will be immediately actionable for providers, health system leadership, advocates, and policymakers seeking to improve perinatal behavioral health outcomes and address a preventable cause of maternal mortality.

PI_NAMEs: FAHERTY, LAURA JOHNSON (contact);LANDIS, RACHEL KELLER

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: ableism;Acceleration;Address;Advocate;Affect;Anxiety Disorders;Appointment;attributable mortality;Automobile Driving;behavioral health;care outcomes;Caring;Cause of Death;Child Care;classism;Color;comparative efficacy;Consolidated Framework for Implementation Research;COVID-19 pandemic;Death Rate;disability;Disability status;Emergency department visit;Equity;ethnic minority population;Ethnic Origin;Event;Evolution;experience;Face;flexibility;geographic disparity;Goals;Health;health care availability;health disparity;health equity;Health Personnel;Health Policy;Health Services;Health system;Healthcare;Improve Access;improved;Individual;Inequity;infant outcome;interest;Interview;Language;Lead;Leadership;Life;longitudinal dataset;marginalized community;marginalized population;Maternal and Child Health;Maternal Health;maternal morbidity;Maternal Mortality;Medicaid;member;Mental Health Services;Methods;Modality;Modeling;Mood Disorders;Morbidity - disease rate;mortality;National Institute of Mental Health;Nature;Outcome;Overdose;pandemic disease;Patients;Perinatal;perinatal period;Persons;Policies;Policy Maker;Population;Postpartum Period;Pregnancy;pregnant;Premature Birth;Prevalence;Prevention;programs;Provider;public health insurance;Quasi-experiment;Race;racial disparity;racial minority population;Research;Research Personnel;Resources;Risk;rural area;rural residence;rurality;Series;Services;socioeconomic disparity;socioeconomics;structural determinants;Structural Racism;Substance Use Disorder;Suicide;Technology;telehealth;Time;Transportation;underserved community;Underserved Population;United States;United States National Institutes of Health;uptake;Variant

PROJECT_TITLE: Impacts of Telehealth Policies on Inequities in Perinatal Behavioral Health Care Access and Outcomes


ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research aims to develop new chemical technologies for efficient preparation of fluorinated molecules, carbonyl compounds, and functionalized carbohydrates. These chemical entities are involved in every aspect of life and can be found in natural products, pharmaceuticals, dyes, pesticides, lubricants, polymers, clothes, and inhaler propellants. The accomplishment of the proposed research will create novel functional molecules to accelerate drug discovery and development, improve the quality of health care products, and promote the establishment of new materials for biomedical applications.

PI_NAMEs: NGAI, MING-YU  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Address;Agrochemicals;Biocompatible Materials;Bioprobe;Carbohydrates;carbonyl compound;Catalysis;catalyst;Chemicals;Complex;Derivation procedure;Development;drug development;drug discovery;Dyes;Goals;health care quality;Hydrocarbons;imaging agent;improved;Inhalators;Life;Lubricants;Natural Products;novel;novel therapeutics;Organic Synthesis;Organometallic Compounds;Oxidation-Reduction;Pesticides;Pharmacologic Substance;Polymers;Preparation;Process;propellant;Reaction;Reagent;Research;Site;sugar;Technology;Therapeutic;Visible Radiation

PROJECT_TITLE: EXCITED-STATE CATALYSIS IN ORGANIC SYNTHESIS


PHR: To decrease the prevalence of preventable blindness due to glaucoma, we need to: 1) screen high-risk populations with increased disease prevalence and decreased access to care and 2) support people who screen positive in accessing appropriate eye care. Federally qualified health centers exist throughout the US to provide care to medically underserved populations – the same populations who are at increased risk of glaucoma. Testing whether telemedicine- enhanced eye disease screening is more effective than usual care in detecting glaucoma at a federally qualified health center will inform best practices for scaling eye care at these health centers and ultimately, mitigating disparities in eye health outcomes.

PI_NAMEs: NEWMAN-CASEY, PAULA ANNE (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: DP24-081 Michigan Screening and Intervention for Glaucoma and Eye Health through Telemedicine (MI-SIGHT) Program: A Pragmatic Randomized Trial


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This study will investigate the role of blood flow abnormalities in glaucoma using novel magnetic resonance imaging (MRI) techniques to study the effects of a novel treatment strategy to increase ocular blood flow on glaucoma progression. These findings could have strong clinical significance and impact by providing new insights into the association of ocular blood flow with glaucomatous damage and by validating a novel therapeutic strategy for glaucoma. These translational MRI and treatment approaches and the knowledge gained could be extended to future human studies, to ultimately prevent visual impairment or blindness from glaucoma.

PI_NAMEs: MUIR, ERIC RAYMOND (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Anatomy;Animal Model;Axon;Blindness;Blood flow;Blood Pressure;Blood Vessels;Choroid;Chronic;clinically relevant;clinically significant;Combined Modality Therapy;Data;density;Diffusion Magnetic Resonance Imaging;Electroretinography;Eye;Functional disorder;functional outcomes;Future;Glaucoma;Goals;hemodynamics;high resolution imaging;Histologic;Histology;Human;Hyperoxia;Hypertension;Imaging Techniques;Impairment;improved;innovation;insight;Intervention;Knowledge;Laboratories;Laser Speckle Imaging;Magnetic Resonance Imaging;Measurement;Measures;Mechanical Stress;Methods;Microspheres;Modeling;Mus;novel;novel therapeutic intervention;Optic Disk;Optic Nerve;Optical Coherence Tomography;optical imaging;Outcome Measure;Pathogenesis;Pathology;Patients;Perfusion;Physiologic Intraocular Pressure;Placebos;Prediction of Response to Therapy;preservation;prevent;Retina;Retinal Ganglion Cells;Rodent;Role;sildenafil;Testing;Treatment Protocols;treatment strategy;vascular abnormality;Vascular Diseases;Vasodilator Agents;Vasospasm;Vision;Visual impairment;Work

PROJECT_TITLE: Vascular dysfunction in glaucoma


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Autism;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Telehealth

ORG_CITY: BOISE

ORG_NAME: CARING TECHNOLOGIES, INC.

ORG_STATE: ID

PHR: The I-Corps curriculum provides real-world, hands-on, immersive learning about what it takes to successfully translate promising technologies into products or services that will benefit society. At the beginning of the training program, all I-Corps team members are required to attend an evening reception plus an intensive, 3-day Kick-Off Workshop (exact location to be announced).

PI_NAMEs: OBERLEITNER, RONALD  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: adolescent with autism spectrum disorder;Educational Curriculum;Educational workshop;Hospitalization;Innovation Corps;Learning;Location;member;novel;Services;Societies;Technology;telehealth;Training Programs;Translating

PROJECT_TITLE: i-Corp -Transforming Hospitalizations of Autistic Adolescents via a Novel ABA Telehealth Platform


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Nutrition;Precision Medicine;Social Determinants of Health

ORG_CITY: LOUISVILLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Existing eating disorder treatments lack the flexibility to adapt to individuals’ symptom and environmental complexities. Further, it is unknown how individual differences impact associated medical and functional complications. This diversity supplement to DP2MH136495 will lead to personalized eating disorder treatment that accounts for social determinants of health, medical comorbidities and functional complications, while providing crucial post-doctoral fellowship training to the diversity supplement awardee.

PI_NAMEs: LEVINSON, CHERI ALICIA (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Achievement;Address;Affective;Aftercare;Automobile Driving;Behavioral Symptoms;Clinical;Clinical Sciences;Cognitive;Communities;comorbidity;cost effective;Development;Disease;Eating Disorders;Etiology;experience;Fellowship;flexibility;food insecurity;functional outcomes;Goals;Health;health related quality of life;Heterogeneity;Individual;Individual Differences;innovation;Intervention;Literature;Longevity;marginalization;Medical;Mental disorders;Methods;network models;Outcome;parent grant;Perception;personalized intervention;personalized medicine;post-doctoral training;Postdoctoral Fellow;psychologic;Psychologist;Quality of life;Research;Research Personnel;Role;social disparities;social health determinants;sociodemographics;Symptoms;Testing;Training;treatment effect;Universities

PROJECT_TITLE: Innovations in Personalizing Treatment for Eating Disorders Using Idiographic Methods and the Impact of Personalization on Psychological, Physical, and Sociodemographic Outcomes


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Public Health Relevance. Riboswitches are metabolite-sensing elements found in the messenger RNAs of many bacterial pathogens. We discovered a very small riboswitch that senses preQ1 using ‘cooperativity’, whereby two identical metabolites are held in close proximity to improve each other’s affinity, which extends the riboswitch’s preQ1-sensing range in cells. This proposal will determine crystal structures of this novel preQ1 riboswitch, develop tools to quantify its cooperative sensing, and probe its function and conformation in live bacteria, thereby elucidating a new gene-regulatory pathway that is relevant to antibacterial discovery.

PI_NAMEs: WEDEKIND, JOSEPH E (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acylation;Address;Affinity;Anti-Bacterial Agents;aptamer;Attributes of Chemicals;Bacteria;Bacterial Genes;Binding;Biological Assay;Biological Process;biophysical techniques;Calorimetry;Cells;Chemicals;Coupled;Crystallography;Data;Drug Targeting;Elements;Foundations;Gene Expression Regulation;Genes;Goals;human pathogen;Hydroxyl Radical;improved;innovation;Ligand Binding;Ligands;Mediating;Messenger RNA;Microscopic;Modification;Molecular;Molecular Conformation;next generation sequencing;novel;Outcome;pathogenic bacteria;Pathway interactions;Play;Primer Extension;Process;public health relevance;Qualifying;Records;Regulatory Pathway;Reporter;restraint;RNA;Role;sensor;software development;Structure;synergism;Titrations;tool;Untranslated RNA;Work

PROJECT_TITLE: Mechanisms of Action On Non-Coding RNA Molecules


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE The University of Iowa MSTP is committed to the goal of training outstanding students for careers as successful physician-scientists. We aspire to train individuals who will be leaders among the next generation of physician-scientists.

PI_NAMEs: BUCHANAN, GORDON F (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: Project Narrative Focused ultrasound (FUS) neuromodulation will be combined with real-time MRI guidance and fMRI feedback to develop acoustic technologies (hardware, software, and activatable particles) for focal pharmacological neuromodulation of the monkey sensorimotor system. Safety will be monitored longitudinally and post-mortem. The proposed developments will improve the spatial capabilities of FUS neuromodulation, expand its use to focal pharmacological modulation, and provide key data to translate this technology to humans.

PI_NAMEs: CASKEY, CHARLES F (contact);CHEN, LI MIN

PROGRAM_OFFICER_NAME: ALVAREZ, RUBEN PAUL

PROJECT_TERMS: Acoustics;Anesthetics;Automobile Driving;Autopsy;Behavioral;Blood - brain barrier anatomy;blood oxygen level dependent;blood-brain barrier permeabilization;Brain;BRAIN initiative;Brain region;Cells;Cephalic;Characteristics;Clinical Trials;Collaborations;Computer software;Contrast Media;cranium;Data;design;Development;Devices;Drug Delivery Systems;Elements;Excipients;Exposure to;Feedback;Focused Ultrasound;Focused Ultrasound Therapy;Formulation;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Growth;Human;Image;image guided;improved;Inflammation;Laboratories;Liquid substance;Magnetic Resonance Imaging;Maps;Methods;Microbubbles;millimeter;millisecond;Modality;Molecular;Monitor;Monkeys;multidisciplinary;nanoemulsion;neuroimaging;Neurons;neuroregulation;next generation;nonhuman primate;open source;particle;patient population;Patients;Pentobarbital Sodium;Pharmaceutical Preparations;pharmacologic;Phase;Physical condensation;Physiologic pulse;pressure;Procedures;Publishing;putamen;Rattus;Research;Research Personnel;response;Risk;Rodent;Safety;safety assessment;Scheme;sensorimotor system;side effect;software development;somatosensory;Spottings;System;Technology;Time;tool;Transducers;Translating;translational model;Translations;treatment planning;Ultrasonic Transducer;ultrasound;Work

PROJECT_TITLE: Next generation transcranial ultrasound-based neuromodulation using phase shift nanoemulsions


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Mutation is the source of all evolutionary novelty and diversity shaping both the structure and sequence of genomes. The genomes of individual somatic cells also accumulate mutations throughout the lifetime of organisms impacting cellular functions and contributing to diseases. The goal of the proposed research is to understand at both the cellular and organismal level how cell-type, genotype, selective pressures, and evolutionary histories influence the structure and sequence of the genome.

PI_NAMEs: SUDMANT, PETER HESHEDAHL (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Architecture;base;cancer genome;Cell Physiology;cell type;Cells;Clonal Expansion;Complex;Computing Methodologies;Disease;Evolution;Genetic Variation;Genome;Genomic approach;Genomics;Genotype;Goals;Human;Individual;Inherited;interest;life history;life span;Malignant Neoplasms;Methods;Molecular;Mutation;Normal Cell;novel;Organism;Pan Genus;Pattern;Phenotype;Predisposition;pressure;Process;Radiation;Recording of previous events;Repetitive Sequence;Research;Shapes;Signal Transduction;Somatic Cell;Somatic Mutation;Source;Structure;Time;Variant;Vertebrates

PROJECT_TITLE: The evolution and diversity of mutation, molecular fidelity, and genome structure


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Beginning in 2024, Oregon state’s Medicaid agency will launch a suite of innovative policies intended to facilitate linkages between clinical systems and community and government services. The expectation is that these programs will reduce health disparities and improve health for the state’s Medicaid members. In the RESOLVE study, we will examine the impacts of these policies on referrals and receipt of social services as well as on chronic disease outcomes and disparities for the state’s Medicaid population.

PI_NAMEs: FICHTENBERG, CAROLINE M;HESSLER, DANIELLE MARIE (contact)

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: Address;Affect;American;analytical method;Body mass index;Caring;Categories;Chronic;Chronic Disease;Clinic;Clinical;clinical implementation;Communities;community clinical linkage;community organizations;comparative;compliance behavior;Data;Data Set;Data Sources;design;Diabetes Mellitus;disease disparity;Disease Management;Disease Outcome;disorder risk;Disparity;Economics;Emergency department visit;Environment;Epidemic;Ethnic Origin;expectation;Failure;Financial Hardship;Food;food insecurity;Goals;Government;Health;health care delivery;health care service organization;health care service utilization;health equity;health plan;Health Services Accessibility;Healthcare;Housing;Hyperlipidemia;Hypertension;improved;Incentives;innovation;instrument;Interruption;Interview;Laboratory Study;Language;Link;long-standing disparities;Malignant Neoplasms;Managed Care;Measures;Medicaid;member;Methods;Neighborhood Health Center;novel;Oregon;Outcome;outcome disparities;Patients;Persons;Policies;Politics;Population;Poverty;Prevalence;Preventive care;Preventive screening;programs;Quasi-experiment;Race;racism;Reduce health disparities;referral services;Resources;response;Risk;Risk Factors;rurality;screening;screening services;Series;Services;social;social adversity;social determinants;social health determinants;Social Work;stem;Stress;System;Target Populations;Time;timeline;Tobacco use;treatment adherence;uptake;Work

PROJECT_TITLE: oREgon medicaid policy, SOciaL serVices, and hEalth (RESOLVE)

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BALTIMORE

ORG_NAME: BALTIMORE VA MEDICAL CENTER

ORG_STATE: MD

PHR: Breast cancer is currently the most often diagnosed cancer and despite recent advances in treatment, remains the second leading cause of cancer-related deaths among women. Once breast cancer has spread (metastasis) it is especially difficult to treat because targeted agents are usually not available. These cancers are prevalent in men and women Veterans and are particularly aggressive in African- American Veterans diagnosed with breast cancer. Mitochondrial metabolism plays a prominent role in drug resistance and breast cancer progression to metastasis, which is associated with poor clinical outcomes. The proposed study seeks to define the role of and the molecular mechanisms underlying metabolic signaling in breast cancer and the therapeutic potential of a small molecule inhibitor selectively targeting mitochondrial metabolism. Defining how genetic changes in cancer regulate nutritional needs of cells will likely have translational impact and is relevant to the VA health care mission.

PI_NAMEs: PASSANITI, ANTONINO  (contact)

PROJECT_TERMS: acquired drug resistance;Activity Cycles;Adenosine Triphosphate;African American;Antioxidants;Biological Assay;Biological Markers;Breast Cancer Cell;breast cancer diagnosis;breast cancer metastasis;breast cancer progression;Breast Cancer therapy;Breast Cancer Treatment;cancer cell;Cancer Cell Growth;cancer diagnosis;Cancer Etiology;cancer stem cell;Cell Culture Techniques;Cell Proliferation;Cell Respiration;Cells;Citrates;Citric Acid Cycle;Clinical;clinical efficacy;Computer Assisted;Data;design;Diagnosis;differential expression;Disease;DNA-Binding Proteins;Drug Design;drug development;drug discovery;drug efficacy;Drug Kinetics;Drug resistance;Drug Targeting;Drug toxicity;electron donor;Electron Transport;Epithelial Cells;Equilibrium;Exhibits;FADH2;Future;Gene Expression Profile;General Population;Genes;Genetic Transcription;Genus Hippocampus;Glucose;Glycolysis;Glycolysis Inhibition;Goals;Growth;Healthcare;Healthcare Systems;Hybrids;Hypoxia;improved;In Vitro;in vivo;Incidence;inhibitor;innovation;Investigational Drugs;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Mammospheres;Measures;Mediating;men;Metabolic;Metabolic Pathway;Metastatic breast cancer;Mission;Mitochondria;mitochondrial metabolism;Modeling;Molecular;mouse model;Mutation;NADH;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;novel therapeutics;Nutritional;Oral;Oral Administration;Outcome;Oxidation-Reduction;oxidative damage;Oxidative Phosphorylation;Oxygen Consumption;Pathway interactions;patient derived xenograft model;patient stratification;Patients;Pharmaceutical Preparations;Phenotype;Play;preclinical development;prevent;Production;Proliferating;pyruvate dehydrogenase;Reactive Oxygen Species;Regulation;research clinical testing;Resistance;Respiration;response;restraint;Role;Safety;Signal Transduction;small molecule;small molecule inhibitor;stem;stem-like cell;targeted agent;targeted treatment;Therapeutic;Therapeutic Agents;therapeutic target;therapeutically effective;tool;Toxic effect;Toxicology;Transcriptional Regulation;transcriptome;transcriptome sequencing;translational impact;translational potential;Tricarboxylic Acids;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor metabolism;tumor progression;Veterans;whole genome;Woman;Women's mortality

PROJECT_TITLE: Mitochondrial metabolism as a target of breast cancer therapy


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: In this project, using magnetic resonance imaging (MRI) techniques, we will define both vulnerable and resilient brain networks involved in aging and Alzheimer’s disease (AD), and uncover new imaging biomarkers to improve AD diagnosis and treatment. Normal aging, as well as occurrence of neurodegenerative diseases such as AD, can be better understood by mapping complex structural and functional brain networks through which information flows, and via the discovery of important biomarkers that shed light on aging and neurodegenerative disease.

PI_NAMEs: AGANJ, IMAN  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Affect;Age;age effect;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer’s disease biomarker;Architecture;Area;automated segmentation;basal forebrain;Biological Markers;Brain;Brain region;Cerebrum;Clinical;Clinical Data;clinical outcome measures;Cognitive;Collaborations;Complex;connectome;Data;Data Pooling;Data Set;Databases;Development;Diagnosis;diagnostic biomarker;Diffusion Magnetic Resonance Imaging;Disease;Distant;drug discovery;Early treatment;Elderly;Exclusion;experimental study;Fiber;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;Goals;Graph;healthy aging;Human;Hypothalamic structure;imaging biomarker;Imaging Techniques;Impaired cognition;improved;Individual;Label;locus ceruleus structure;longitudinal dataset;Magnetic Resonance Imaging;Manuals;Maps;Mathematics;Measures;Mediating;Methods;mild cognitive impairment;Modeling;Network-based;Neural Pathways;Neurodegenerative Disorders;neuroimaging;Neurologic;Neurons;normal aging;novel;Outcome;Pathway interactions;Patients;Pattern;Persons;Population;pre-clinical;prevent;Prognosis;prototype;Research;Research Personnel;resilience;resilience in aging;Rest;Signal Transduction;Speed;Staging;Stratification;Structure;Synapses;Syndrome;Therapeutic;therapy development;tractography;Training;Treatment Efficacy;Variant

PROJECT_TITLE: Connectomic Biomarkers of Preclinical Alzheimer's Disease within Multi-Synaptic Pathways

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Hematology;Infectious Diseases;Networking and Information Technology R&D (NITRD);Sepsis

ORG_CITY: Boxborough

ORG_NAME: HELIXBIND, INC.

PHR: PROJECT NARRATIVE Sepsis, the body’s response to a bloodstream infection, is often life-threatening. Timely administration of appropriate antimicrobials is critical for successfully patient outcomes. However, current diagnostics for identifying the infection, necessary for selection of the appropriate antimicrobial, require several days to provide results. The proposed efforts described in this Commercialization Readiness Pilot program proposal will advance the maturity of a novel, fully automated test capable of identifying and characterizing these infections directly from blood in only a few hours. Success in this effort will result in a critically needed diagnostic device, ready for manufacturing scale up as required for FDA trials and market launch.

PI_NAMEs: SINGER, ALON  (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Address;Adopted;antimicrobial;Antimicrobial Resistance;assay development;Automation;Biological Assay;Blood;Breakthrough device;Budgets;Caring;Cessation of life;Clinic;Clinical;Clinical Microbiology;Clinical Research;commercialization;commercialization readiness;Communicable Diseases;Complex;Computer software;cost;cyber security;design;Detection;Deterioration;Development;Devices;Diagnostic;Diagnostic Equipment;diagnostic strategy;Early Diagnosis;Early treatment;Electronic Health Record;Engineering;Ensure;Exhibits;experience;Feedback;Health Insurance Portability and Accountability Act;Hospitalization;Hospitals;Hour;improved;Indiana;Infection;Injections;institutional financing;instrument;instrumentation;Intervention;Laboratories;Lead;Life;manufacture;manufacturing capabilities;manufacturing scale-up;Marketing;Medical center;member;Methods;microbial;Mission;Molds;Molecular;mortality;National Institute of Allergy and Infectious Disease;novel;novel diagnostics;pathogen;pathogenic bacteria;pathogenic fungus;patient prognosis;Patient-Focused Outcomes;Patients;Phase;Preparation;Process;programs;Quality of life;Resistance;Resistance development;resistance mechanism;response;Sampling;Sepsis;Septicemia;Small Business Innovation Research Grant;Specificity;Specimen;success;System;systemic inflammatory response;Technology;Temperature;Testing;Time;timeline;tool;Universities;University Hospitals;verification and validation;Whole Blood

PROJECT_TITLE: Commercialization Readiness Pilot (CRP) program support for: An Integrated Device for identification of bloodstream infections directly from blood


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative To end the HIV epidemic, we need integrated care models that address HIV and PrEP care, and co-existing substance use (SU) disorders that disrupt uptake and consistent use of effective interventions. The overarching goal of this R01 proposal is to conduct a randomized controlled trial to assess the ability of a Collaborative Care Prevention, Treatment, Navigation, Engagement, Resource (PrTNER) intervention to increase initiation of preexposure prophylaxis (PrEP) (for those at-risk for HIV) and decrease viral load (for those living with HIV) among young Black and Latino men who have sex with men (YBLMSM) aged 15 to 24 through engagement in SU treatment. This model moves beyond the individual to consider the broader context in which, substance use and HIV risk are (re)produced.

PI_NAMEs: SANDERS, RENATA A (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: Address;Adherence;Adolescent;aged;AIDS prevention;Alcohol consumption;Alcohols;Anal Sex;Anti-Retroviral Agents;antiretroviral therapy;arm;Baltimore;black men who have sex with men;Black race;Cannabis;care delivery;Caring;collaborative care;Communication impairment;condomless anal sex;condoms;County;Decision Making;effective intervention;Eligibility Determination;Epidemic;ethnic disparity;experience;falls;Feedback;Geography;Goals;Health;Hispanic;HIV;HIV Infections;HIV risk;HIV/AIDS;illicit drug use;Illicit Drugs;Individual;integrated care;Intervention;Latino;Link;Marijuana;marijuana use;medication nonadherence;member;men who have sex with men;Modeling;multi-component intervention;Participant;Pattern;peer coaching;Philadelphia;polysubstance use;Population;pre-exposure prophylaxis;pressure;Prevalence;Prevention;primary care services;Psychiatrist;racial disparity;randomized trial;Randomized, Controlled Trials;reduced substance use;Reporting;Research;Resources;Risk;Risk Factors;sex;sexual minority men;standard of care;substance use;Substance Use Disorder;substance use treatment;Time;Unsafe Sex;uptake;Viral;Viral Load result;Work

PROJECT_TITLE: The Collaborative Care PrTNER (Prevention, Treatment, Navigation,Engagement, Resource) Project


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SYRACUSE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE Organoids are powerful laboratory models of functional organs in the human body. However, their clinical utility is limited because they don’t fully mimic their full-scale counterparts. Here, we seek to address limitations with current methods for growing intestinal organoids in the lab by using engineered biomaterials to characterize and guide growth to build better mini-guts with increased translational potential.

PI_NAMEs: BLATCHLEY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: 3-Dimensional;Address;Adult;age effect;Amino Acids;Architecture;Atlases;Award;Benchmarking;beta catenin;Biochemical;Biocompatible Materials;Bioinformatics;Biology;Biomimetics;Blood Vessels;capsule;cell fate specification;Cell Shape;Cells;Clinical;Complex;Complex Mixtures;Conceptions;Consult;Cues;Cytoskeleton;design;Development;Developmental Biology;developmental disease;differentiation in vitro;differentiation protocol;Dimensions;directed differentiation;Disease;disease model;Dose;Engineering;Epithelium;ethylene glycol;Exposure to;Extracellular Matrix;Extracellular Matrix Proteins;fetal;Fluorescence;Frequencies;Future;Generations;genetic signature;Geometry;Germ Layers;Global Change;Growth;Human;Human body;Human Development;human disease;human induced pluripotent stem cells;human model;Hydrogels;Image;Image Analysis;Imaging Techniques;implantation;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Integrin Binding;intestinal crypt;Intestines;Kidney;Label;Laboratories;Lead;Learning;LGR5 gene;Light;Malignant Neoplasms;matrigel;Measures;mechanical properties;Mechanics;mechanotransduction;Mentors;Mesenchymal;Mesenchyme;Metabolic;Methods;Microscopy;Modeling;Morphogenesis;Mus;Nerve;notch protein;Nuclear;Organ;Organoids;Patients;Pattern;Phase;Phenotype;Population;programs;Property;Proteins;Protocols documentation;Reporter;Research;Research Personnel;Rheology;Role;Signal Transduction;single-cell RNA sequencing;Source;spatiotemporal;Specific qualifier value;Specificity;Spectrum Analysis;stem cell organoids;stem cells;Techniques;three dimensional structure;Time;Tissues;Training;translational potential;Villus

PROJECT_TITLE: 4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and form


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHOENIX

ORG_NAME: ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Synaptic dysfunction is considered an early event during disease manifestation and progression in many dementias, including frontotemporal dementia (FTD) and has been proposed to be associated with microglia dysfunction, including microglia-mediated synaptic pruning. The question remains to whether it is the aberrant proteome of the synapse or the disease-associated microglia dysfunction that triggers early synapse loss. Here we aim to define a disease-associated synaptome via multi- omics analyses of human C9orf72 FTD brain tissue derived cortical synapses and to assess whether an aberrant synaptome triggers aberrant microglia phagocytosis using human C9orf72 FTD patient- derived iPSC neuron-glia cell culture models.

PI_NAMEs: HUENTELMAN, MATT ;SATTLER, RITA  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Alzheimer's Disease;Autopsy;Biological Models;Brain;brain tissue;C9ORF72;Cell Culture Techniques;Dementia;Disease;Disease associated microglia;Electrophysiology (science);Event;Frontotemporal Dementia;Functional disorder;graduate student;Guanine;Guanine Nucleotide Exchange Factors;Heterogeneity;Human;human disease;Immune signaling;Induced Mutation;Induced pluripotent stem cell derived neurons;Lead;Mediating;Microglia;Microscopy;Modeling;Molecular;mouse model;multiple omics;Mutation;Neurodegenerative Disorders;Neuroglia;Neurons;new therapeutic target;Pathologic;patient derived induced pluripotent stem cells;Patients;Phagocytosis;Phenotype;Play;postsynaptic;presynaptic;protein profiling;Proteins;Proteome;rab GTP-Binding Proteins;RNA;Rodent Model;Role;Signal Transduction;Structure;Synapses;synaptic pruning;Technology;Time;Tissues;trafficking;transcriptome;transmission process;Vesicle

PROJECT_TITLE: The role of an aberrant synaptome in microglia-associated synaptic pruning in C9orf72-FTD


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: NARRATIVE  Many complex disorders of the brain, such as schizophrenia, autism, and depression, can be construed as disorders of brain connectivity. This research aims to bridge the gap between gene expression and connectivity towards elucidating the genetic programming of neural circuit architectures. Decoding the genes that play a role in the formation and maintenance of neuronal networks can provide entry points toward developing therapeutic targets for mental health disorders related to brain connectivity.

PI_NAMEs: VAROL, ERDEM  (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 3-Dimensional;Anatomy;Animal Model;Animals;Architecture;Area;autism spectrum disorder;Award;Behavior;Biological;Brain;Brain Diseases;Cadherins;Caenorhabditis elegans;Calcium;Cell Adhesion Molecules;Cells;Code;combinatorial;Communities;Complex;computational neuroscience;Computational Technique;Computer Models;computerized tools;connectome;Data;Data Set;Defect;design;Ensure;Gap Junctions;Gene Combinations;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;genetic effector;Genetic Programming;Genetic Transcription;Heterogeneity;Hippocampus;Image;Image Analysis;in vivo;Individual;Interneurons;Linear Models;Location;Maintenance;Memory;Mental Depression;Mental disorders;Mentors;Mentorship;Molecular;monoamine;mouse model;multi-photon;Mus;mutant;Nervous System;neural;neural circuit;Neurobiology;Neurons;Neuropeptides;neuroregulation;Neurosciences;novel;Pattern;Phase;Play;postsynaptic;presynaptic;presynaptic neurons;professor;programs;Pyramidal Cells;reconstruction;Reporter Genes;Research;Research Personnel;Resolution;Rodent;Rodent Model;Role;Schizophrenia;Signal Transduction;single-cell RNA sequencing;skills;Specific qualifier value;Stereotyping;Synapses;System;Techniques;Testing;theories;therapeutic target;Tissue-Specific Gene Expression;tool;Training;transcriptome;transcriptomics;Transgenic Organisms;Universities;Validation;virtual environment;Visualization;wireless

PROJECT_TITLE: Transcriptional basis of stereotyped neural architectures


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Hematology;Nutrition

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: Project Narrative Although consumption of marine fish oils appears to be associated with lower cardiovascular risks, the evidence is inconsistent and the mechanisms for their cardioprotective effects remain elusive. Our preliminary findings suggest different component of fish oils (EPA vs DHA) have differential effects on blood clots. Our proposed studies will provide insight into a new paradigm of understanding the puzzling clinical evidence of fish oils and may ultimately lead to the development of more targeted therapies to combat cardiometabolic risk.

PI_NAMEs: SONG, WENLIANG  (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Address;Affect;Apolipoprotein A-I;Biological;Biological Markers;Blood coagulation;Blood Platelets;cardiometabolic risk;cardioprotection;cardiovascular risk factor;Cardiovascular system;Clinical;Clinical Research;Clinical Trials;Coagulation Process;combat;Consumption;Data;design;Development;Diet;Dietary Supplementation;Docosahexaenoic Acid n-3;Docosahexaenoic Acids;Dose;Dyslipidemias;eicosanoid metabolism;Eicosapentaenoic Acid;epidemiology study;Experimental Models;experimental study;Fish Oils;Flow Cytometry;Head;head-to-head comparison;healthy volunteer;Hemorrhage;High Density Lipoproteins;Human;human subject;in vivo;insight;Intervention;Investments;Knock-out;Knockout Mice;Laboratories;Leukocytes;lipid mediator;Lipids;Lipoproteins;marine;Mediating;Modeling;Modification;mouse model;Mus;N-3 polyunsaturated fatty acid;novel therapeutics;Omega-3 Fatty Acids;Outcome;outcome disparities;particle;Patients;Phospholipids;Platelet Activation;Platelet aggregation;platelet function;Population;Pre-Clinical Model;Principal Investigator;Production;Property;Randomized;reconstitution;Regimen;Reporting;Resources;Rest;Single-Blind Study;Supplementation;targeted treatment;Testing;Therapeutic Effect;Thrombelastography;thrombogenesis;Thrombosis;thrombotic;Thromboxanes;Triglycerides;urinary;Whole Blood

PROJECT_TITLE: Differential thrombogenesis effects of EPA and DHA mediated by HDL

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: The incidence of acute type B aortic dissection is proportional to the prevalence of uncontrolled hypertension. The results of the IMPROVE-AD trial (including 1100 participants in the US) will provide important clinical guidance on the most appropriate patient-centered ways to reduce mortality and major morbidity by testing two distinct therapeutic strategies. It will also inform decisions regarding racial and gender disparities in patients with uncomplicated type B aortic dissection.

PI_NAMEs: KOUGIAS, PANAGIOTIS ;MUSSA, FIRAS FUAD;PATEL, MANESH R (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Abdominal Aortic Aneurysm;Acute;Address;Admission activity;Advocate;African American population;Ancillary Study;Aorta;Aortic Diseases;Aortic Rupture;arm;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Cessation of life;Chest;Clinical;Clinical Research;Clinical Trials;clinically relevant;college;cost;Cost Analysis;cost effectiveness;Creativeness;Data;Data Coordinating Center;Descending aorta;design;Deterioration;Dialysis procedure;Disease;Dissection;Elderly;Enrollment;Equipoise;European;Event;experience;Fistula;follow-up;Funding;gender disparity;Guidelines;Health;health difference;Hispanic;Hospital Costs;Hospital Mortality;hospital readmission;Hospitalization;Hypertension;Image;implementation research;improved;improved outcome;Incidence;indexing;Individual;Industry;Injury;Intervention;Leadership;limb loss;Medical;Medicine;Minority;Morbidity - disease rate;mortality;Multicenter Trials;multidisciplinary;Myocardial Infarction;National Heart, Lung, and Blood Institute;Operative Surgical Procedures;Organ;Outcome;Pain;Pain management;Paraparesis;Paraplegia;Participant;patient oriented;Patients;Population;pragmatic trial;Prevalence;Prevention;primary endpoint;Quality of life;Quality of Life Assessment;Questionnaires;racial disparity;Randomized;Recommendation;Renal Replacement Therapy;repaired;Research Institute;Research Personnel;Risk;Safety;Spinal cord injury;standard of care;Strategic vision;Stroke;Surveys;Syndrome;Telephone;Testing;Therapeutic;Time;treatment strategy;Universities;Vascular Diseases;Washington

PROJECT_TITLE: 1/2 IMPRoving Outcomes in Vascular DisEase - Aortic Dissection (IMPROVE-AD)


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: ROUND ROCK

ORG_NAME: DELL FEDERAL SYSTEMS L.P.

ORG_STATE: TX

PHR: No PHR

PI_NAMEs: HAMMONDODWYER, AMY K (contact);SIDDIQUI, ERUM

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Services;Training;United States National Institutes of Health

PROJECT_TITLE: NIH STRIDES - Azure and Associated Services and Training.


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE  Pseudomonas aeruginosa is an opportunistic bacterial pathogen that can survive antibiotic treatment even without identifiable antibiotic resistance genes and cause chronic or recurrent infections. The central objective of this project is to understand the mechanisms that P. aeruginosa uses to survive treatment with two different classes of antibiotic and how interactions with another species, S. aureus, affects P. aeruginosa’s phenotypic responses to the drugs. Completion of this research can inspire novel treatment strategies to reduce the burden of P. aeruginosa infections and preserve the effectiveness of existing antimicrobial agents.

PI_NAMEs: HARE, PATRICIA JIN (contact)

PROGRAM_OFFICER_NAME: MCGUIRL, MICHELE

PROJECT_TERMS: Affect;Aftercare;anti-microbial drug;Antibiotic Resistance;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Automobile Driving;Bacteria;Bacterial Physiology;bactericide;Basic Science;Biocide;biological adaptation to stress;Biological Assay;Cell Separation;Cell Survival;Cells;Chlorhexidine;chronic infection;chronic wound;Classification;Clinical;clinically relevant;Coculture Techniques;Collaborations;Communities;Competitive Behavior;Complement;Dentists;design;Development;differential expression;DNA Damage;DNA Repair Pathway;Dose;Drug Tolerance;Effectiveness;Engineering;Environment;Escherichia coli;Excision;feeding;Fellowship;Flow Cytometry;Fluoroquinolones;Future;Gene Expression;Genes;Genetic;Genetic Models;genetic testing;Genetic Transcription;Health;Health Care Costs;Heterogeneity;in vivo;Individual;Infection;infection management;insight;interest;Knock-out;knockout gene;Knowledge;Laboratories;Lead;Learning;Levaquin;Lung infections;Membrane;Microbial Biofilms;microbial community;Microscopy;model organism;Molecular;multidrug-resistant Pseudomonas aeruginosa;mutant;Nonhomologous DNA End Joining;novel;Nutrient;opportunistic pathogen;oral bacteria;Oral cavity;pathogenic bacteria;Pathway interactions;persistent bacteria;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiology;Population;Predisposition;preservation;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;Recovery;recurrent infection;Relapse;repaired;Reporter;Research;Research Proposals;Resistance;Resistance development;resistance gene;response;Resuscitation;Sampling;Scientist;secondary metabolite;segregation;Serial Passage;Site;skills;Sorting;Specific qualifier value;Specificity;Sputum;Staphylococcus aureus;stress tolerance;stressor;Surface;System;Technical Expertise;Techniques;Testing;tool;transcriptome sequencing;transcriptomics;treatment strategy;Validation

PROJECT_TITLE: Molecular Mechanisms of Pseudomonas aeruginosa Antibiotic Persistence in Monocultures and Microbial Communities

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NORMAL

ORG_NAME: ILLINOIS STATE UNIVERSITY

ORG_STATE: IL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the development of a versatile strategy for the robust and directional immobilization of antibodies onto gold nanoparticles is anticipated to advance emerging diagnostic, imaging, and therapeutic technologies. This proposed work is consistent with NIH’s mission to elucidate protein interactions with nanomaterials to facilitate the development of nanostructured assemblies for potential use in medical applications.

PI_NAMEs: DRISKELL, JEREMY D. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Address;Adsorption;Affinity;Antibodies;antigen binding;Binding;Binding Proteins;Biological;Biological Assay;Charge;Chemicals;Chemistry;Coupling;crosslink;Cysteine;Data;density;design;Detection;Development;Diagnostic;Disease;Drug Delivery Systems;Elements;Environment;Enzymes;Exhibits;Fc Immunoglobulins;functional group;Funding;Glutaminase;Goals;Image;Imaging technology;Immobilization;Immunoassay;Immunoglobulin Fragments;Immunoglobulin G;In Situ;innovation;insight;instrument;Intervention;Laboratories;Learning;Lysine;Mass Spectrum Analysis;Measures;Mediating;Medical;microbial;Mission;Modification;Motivation;nanobiotechnology;nanoGold;nanomaterials;nanoparticle;Nanostructures;novel;novel strategies;Outcome;Peptide antibodies;Peptides;polypeptide;Process;Property;Protein Engineering;Proteins;Public Health;Publications;Reagent;Research;Resolution;Role;Site;skills;small molecule;student participation;Students;Sulfhydryl Compounds;Surface;symposium;Technology;technology platform;Testing;Therapeutic;undergraduate student;United States National Institutes of Health;Work;zeta potential

PROJECT_TITLE: Supplemental Funds for SPR Instrument