PHR: Trauma is a major cause of mortality and morbidity in American soldiers and veterans. As a typical type of trauma, thermal injury results from flame/chemical burns in combat or anti-terrorist actions. Despite the improved critical care and wound management, posttraumatic complications remain a life-threatening problem that causes extended hospital stay and charges. The gut plays an important role in the development of multiple organ complications following a severe burn. Gut barrier failure contributes to systemic inflammatory syndrome and sepsis by serving as the major site of blood leakage and bacteria translocation. The mechanisms of leaky guts are poorly understood. This study provides a comprehensive evaluation of the molecular pathways leading to gut hyperpermeability during burn. This research work has the potential to impact the development of surgical or medical interventions against gut barrier injury in VA patients with trauma or inflammatory bowel disease.

PI_NAMEs: WU, MACK H (contact)

PROJECT_TERMS: Achievement;Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adherens Junction;adipose derived stem cell;Aging;American;American soldier;Animal Model;Area;Atherosclerosis;Award;Bacteria;Bacterial Translocation;Basement membrane;Blood;Blood Circulation;Blood Vessels;career;Cells;Chairperson;Chemical Burns;Chronic;chronic wound;Clinical;clinical risk;clinically relevant;Collaborations;combat;Communities;Complex;Critical Care;Cultured Cells;Development;Diabetes Mellitus;Disease;Disseminated Malignant Neoplasm;Dissociation;effective therapy;Endothelium;Epithelial Attachment;Epithelium;Evaluation;exosome;experimental study;Extravasation;Failure;Focal Adhesion Kinase 1;Focal Adhesions;Functional disorder;Funding;gastrointestinal;gastrointestinal epithelium;genetic approach;Goals;heat injury;high risk;Hospital Charges;Human;Impairment;improved;in vitro Model;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;Intercellular Junctions;Intervention;intestinal barrier;intestinal epithelium;Intestinal permeability;Intestines;Leaky Gut;Length of Stay;Life;Literature;Lung;lung injury;Lymph;Mediating;Mediator;Medical;Medicine;Mesentery;military veteran;Molecular;Molecular Target;Morbidity - disease rate;mortality;Multiple Organ Failure;novel;Obesity;Operative Surgical Procedures;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;Phase;Physicians;Physiological;Plasma;Play;Population;programs;Property;Pulmonary Edema;release factor;Reporting;Research;Research Design;Research Personnel;Research Project Grants;response;restenosis;Role;Scientist;Sepsis;Services;severe burns;Signal Transduction;Site;stem cell exosomes;Structure;Syndrome;systemic inflammatory response;Testing;Therapeutic;Tight Junctions;Tissues;Toxin;Trauma;treatment effect;United States National Institutes of Health;Vascular Diseases;vascular inflammation;Veterans;Work;wound care;wound healing;wound injury;wound treatment


ADMINISTERING_IC: VA

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SOUTHERN ARIZONA VA HEALTH CARE SYSTEM

ORG_STATE: AZ

PHR: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease and currently there is no cure. Veterans are at a higher risk of being affected with the disorder, thus ALS has been listed as a disease entitled to presumptive service connection. The PI’s Merit project is to use well-defined genetic models to determine the mechanisms by which mutations in the RNA binding protein FUS disrupt protein biosynthesis and RNA metabolism and induce downstream toxicity and neuronal death. The results from his project will not only provide critical insights into the pathophysiology of ALS but will also identify novel targets for therapeutic developments. Since the relocation to Tucson, the PI has taken new responsibilities as the site PI of the nationwide VA Biorepository Brain Bank (BBB). As the only ALS biorepository for veterans across the U.S., VA BBB is a critical resource for the entire ALS research community. The support from the Research Career Scientist program will enable the PI to make continuous contributions to the healthcare of veterans, particularly those afflicted with ALS.

PI_NAMEs: ZHU, HAINING  (contact)

PROJECT_TERMS: Affect;aging population;Amyotrophic Lateral Sclerosis;Arizona;Award;Binding;biobank;Boston;Brain;career;Cells;Chromatin;cohort;Collaborations;Communication;Communities;Complex;Contracts;Cytoplasm;Cytoplasmic Granules;Defect;Disease;Drosophila genus;drug development;effective therapy;empowerment;Equilibrium;familial amyotrophic lateral sclerosis;Frontotemporal Dementia;Functional disorder;Funding;fused in sarcoma;Future;gain of function;Genes;Genetic Models;Genets;Goals;Health Benefit;Healthcare;Healthcare Systems;high risk;innovation;insight;Joints;Journals;Karyopherins;Laboratories;Laboratory Finding;Liquid substance;loss of function;Mediating;military veteran;Mission;Modeling;Molecular;Motor Neurons;mRNA Decay;mutant;Mutation;mutation carrier;Nature;Neurodegenerative Disorders;neuron loss;Neuronal Dysfunction;Neurosciences;new therapeutic target;Nonsense-Mediated Decay;novel;Nuclear;Nuclear Fusion;nucleocytoplasmic transport;operation;Pathogenesis;Pathologic;patient derived induced pluripotent stem cells;Phase;Physiological;Play;Productivity;programs;Property;Protein Biosynthesis;Proteins;Published Comment;Publishing;receptor;Research;research and development;Research Support;resilience factor;Resources;Retirement;RNA;RNA Decay;RNA metabolism;RNA-Binding Proteins;Role;Scientist;Services;Site;Specificity;sporadic amyotrophic lateral sclerosis;Structure;success;System;Testing;therapeutic development;Toxic effect;Transcriptional Regulation;translational impact;Translational Research;Translations;Veterans;Work

PROJECT_TITLE: BLRD Research Career Scientist Award Application


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: HATTIESBURG

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative This exploration into a new therapeutic platform technology is relevant to public health for two major reasons. First, this platform will provide proof-of-concept evidence for a new strategy to mitigate damage associated with the upregulation of extracellular reactive oxygen species (ROS), through polymerization. Secondly, this approach will generate scaffolds for tissue regeneration at the site of ROS upregulation that could be highly amenable to many diseases and injuries demonstrating broad applicability of this intervention.

PI_NAMEs: CLEMONS, TRISTAN  (contact)

PROGRAM_OFFICER_NAME: FEHR, TUBA HALISE

PROJECT_TERMS: Acrylamides;Address;Affect;antioxidant therapy;Antioxidants;Binding Sites;bioactive scaffold;Biochemical;Biocompatible Materials;biocompatible polymer;Biological;Biological Assay;Biology;biomaterial compatibility;biomaterial development;Burn injury;Cell Death;cell injury;Cell surface;Cell Survival;Chemicals;Chemistry;Collaborations;Consumption;Coupled;crosslink;Disease;efficacy evaluation;Environment;extracellular;Extracellular Matrix;Heart Diseases;improved;In Situ;In Vitro;in vitro Model;in vivo Model;Injury;innovation;interest;Intervention;Ischemia;ischemic injury;Label;Literature;Malignant Neoplasms;Mammalian Cell;Mechanics;Medical center;Mississippi;Modeling;Modification;monomer;Morbidity - disease rate;mortality;Myocardial Infarction;Myocardial Ischemia;Natural regeneration;novel;novel therapeutics;Oxidants;Oxidative Stress;peptide amphiphiles;Peptide Synthesis;Peptides;Pharmaceutical Preparations;physiologic stressor;Physiological;Play;polymerization;Polymers;Production;Public Health;Rattus;Reaction;Reactive Oxygen Species;Recovery;regeneration potential;regenerative;Reperfusion Injury;Role;scaffold;Signal Transduction;Site;Stroke;Structure;success;Techniques;technology platform;Testing;Therapeutic;Therapeutic Effect;therapy development;tissue regeneration;tissue support frame;Tissues;Universities;Up-Regulation;Vision;Vitamin K 3;Work

PROJECT_TITLE: Biology the initiator: Harnessing Reactive Oxygen Species for Biocompatible Polymerization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-D(81)S]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: ANN ARBOR

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Conformational Control of Protein Kinases Protein kinases (PKs) play an important role in healthy and diseased cell signaling. However, we do not fully understand the complex signaling of PKs because we lack tools to understand the full scope of kinase signaling. In this proposal, we develop a series of tools to study noncatalytic signaling of PKs.

PI_NAMEs: SOELLNER, MATTHEW B (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: acquired drug resistance;Address;Adopted;Architecture;Attention;Auras;Awareness;Binding;Biochemical;Biological Assay;Biosensor;BRAF gene;Catalytic Domain;Cells;Chemicals;Clinical;clinically relevant;Communities;Complex;design;Disease;Distant;Drug Binding Site;Drug Industry;Drug resistance;Drug Targeting;Environment;Epidermal Growth Factor Receptor;FDA approved;functional outcomes;Funding;Generations;Genetic;Goals;high throughput screening;improved;Industry;inhibitor;kinase inhibitor;Length;Ligand Binding;Methodology;Methods;Molecular Conformation;Mutation;next generation;novel;Peptide Hydrolases;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Play;Point Mutation;Process;Protein Conformation;protein function;Protein Inhibition;Protein Kinase;protein protein interaction;protein-tyrosine kinase c-src;Proteins;Proteolysis;Publishing;Quaternary Protein Structure;Regulation;Reporting;Resistance;resistance mechanism;resistance mutation;Role;Scaffolding Protein;Series;SH3 Domains;Signal Pathway;Signal Transduction;Signaling Protein;Site;SRC gene;src Homology Region 2 Domain;synergism;Thermolysin;tool

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BOSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative In the era of genomic medicine, we can accelerate the development of diagnostics and therapeutics through data science tools that equip scientists with the means to make sense of genomic datasets. Given the critical role of data visualization in making discovery more eﬃcient and communication more eﬀective, we are proposing to develop an innovative grammar-driven framework for interactive visualization of both bulk and single-cell genomics data. The design of the framework and the tools built on it will be guided by user-driven development approaches to ensure that they cater to experimentalists, data analysts, and software developers.

PI_NAMEs: GEHLENBORG, NILS  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Address;Basic Science;Biological Assay;Cells;Clinical;Code;collaborative environment;Communication;Communities;complex data;Computer software;computerized tools;Custom;Data;Data Analyses;data portal;Data Science;Data Set;data visualization;Democracy;design;Development;diagnostic development;Disease;Disease Progression;Drops;experience;Experimental Designs;flexibility;Future;Genome;Genome Mappings;genomic data;Genomic medicine;genomic tools;genomic variation;Genomics;graphical user interface;Health;Human;improved;innovation;insight;interactive visualization;Knowledge;Libraries;Link;Metadata;multiscale data;novel;novel diagnostics;novel therapeutics;Online Systems;phenotypic data;Play;Population;Process;Pythons;Recommendation;Research;Research Design;Research Personnel;Role;Scientist;single cell genomics;skills;Software Engineering;Specific qualifier value;success;System;task analysis;Taxonomy;Techniques;Therapeutic;tool;Training;Visual;visual map;Visualization;Visualization software;web-based tool;Work;Writing

PROJECT_TITLE: Grammar-Driven Genomic Data Visualization

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Rheumatoid Arthritis is prevalent in the veteran population. Therapy for rheumatoid arthritis has greatly improved over the past 15 years, but cardiovascular morbidity and host immune impairment are in need of improved care measures. In order to improve cardiovascular and immune health in this patient population further mechanistic investigation of host immune function and cardiovascular function is intended to develop therapeutic strategies.

PI_NAMEs: ANTHONY, DONALD D (contact)

PROJECT_TERMS: Accounting;Aging;Angiography;Antigens;Area;arterial tonometry;arthritis therapy;Atherosclerosis;attributable mortality;attributable risk;Autoimmune Diseases;Biological;Biological Products;cancer risk;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Caring;CD8B1 gene;Chronic;Chronic Disease;chronic infection;cofactor;Coronary Arteriosclerosis;cytokine;Data;Dendritic cell activation;Dendritic Cells;disability;Disease;Electrocardiogram;Endothelium;Erythrocytes;Evaluation;Event;Frequencies;Genes;Genetic Engineering;Goals;Heart Diseases;Hepatitis A;Hepatitis B;Host Defense;Human;IL6 gene;Immune;immune activation;immune function;immune health;Immune response;Immune System Diseases;Immunization;Immunologic Markers;Impairment;improved;Incidence;Infection;Influenza;influenza virus vaccine;Interleukin-6;Interruption;Investigation;Joints;Leflunomide;Measures;Methotrexate;military veteran;monocyte;Morbidity - disease rate;Musculoskeletal;neoantigen vaccine;neoantigens;Outcome;Participant;Pathogenicity;Pathway interactions;patient population;Patients;Peripheral;Plasma;Population;Protein Engineering;Receptors, Tumor Necrosis Factor, Type II;Rheumatoid Arthritis;rituximab;T-Lymphocyte Subsets;Testing;Tetanus;Therapeutic;Thromboplastin;Time;TNF gene;TNFRSF1B gene;Vaccine Antigen;vaccine response;Vaccines;Veterans;Virus Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Impact of Immune Activation on Cardiovascular and Immune Health in RA


ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

ORG_STATE: CA

PHR: NARRATIVE Dr. Ngan F. Huang's translational research program focuses on cardiovascular disease and traumatic muscle injury, both of which are highly relevant in Veteran populations. The goal of her research program is to develop novel therapeutic strategies to improve tissue regeneration and functional restoration to cardiovascular and skeletal muscle diseases/injuries experienced by Veterans. Active research awards from the Department of Veteran Affairs and National Institutes of Health seek to develop engineered tissues with spatially patterned biomaterials that direct cell fate and tissue function, the engineering of vascularized tissues for improved skeletal muscle tissue survival and function, and the development of synthetic hydrogels with controllable mechanical properties that modulate the survival of transplanted tissues for treatment of peripheral arterial disease. If successful, these studies will impact Veteran care by reducing mortality and improving the quality of life.

PI_NAMEs: HUANG, NGAN F. (contact)

PROJECT_TERMS: Ablation;Adipose tissue;Anastomosis - action;angiogenesis;Animals;Area;Award;Biochemical;Biocompatible Materials;Biomechanics;Biomedical Engineering;Biomedical Research;blood perfusion;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;career;Caring;Cell Fraction;Cell secretion;Cell Survival;Cells;Circulation;collagen scaffold;controlled release;Cues;cytokine;Development;Diabetes Mellitus;Disease;Doctor of Philosophy;Endothelial Cells;Endothelium;Engineering;exercise rehabilitation;experience;Extracellular Matrix;Fostering;functional restoration;Funding;Generations;Geometry;Goals;Grant;Health;high risk;Human;human induced pluripotent stem cells;human old age (65+);Hydrogels;Hypertension;improved;Incidence;indexing;induced pluripotent stem cell;Injections;injured;Injury;insight;Ischemia;Knowledge;Laboratories;Laboratory Research;Legal patent;limb ischemia;Limb structure;mechanical properties;Mechanics;Mediating;Medical center;military veteran;mimetics;mortality;mouse model;Mus;Muscle;muscle engineering;Muscle Fibers;muscle form;muscle progenitor cell;muscle regeneration;muscular structure;Myocardial Infarction;Myopathy;nano;nanofibrillar;Neuromuscular Junction;novel therapeutic intervention;novel therapeutics;Nutrient;Obstruction;Oxygen;paracrine;Pattern;Peer Review;Perfusion;Peripheral arterial disease;Physiological;Play;Process;Productivity;programs;Proteins;Proteomics;Publications;Publishing;Quality of life;regenerative rehabilitation;Rehabilitation therapy;Relaxation;Reporting;Research;Research Personnel;restoration;revascularization;Risk Factors;Role;Saline;scaffold;Scientist;Seminal;Services;Signal Pathway;Site;Skeletal Muscle;Smoking;Source;Stress;Structure;Therapeutic;Tissue Engineering;tissue regeneration;Tissue Survival;Tissue Transplantation;Tissues;Training;transcriptomics;Translating;translational research program;Transplantation;United States Department of Veterans Affairs;United States National Institutes of Health;Vascular Endothelial Cell;vascular tissue engineering;Vascularization;Veterans;volumetric muscle loss;Work


ORG_CITY: LOS ANGELES

ORG_NAME: VA GREATER LOS ANGELES HEALTHCARE SYSTEM

PHR: Schizophrenia and related psychotic disorders are a major cause of disability worldwide. Current treatments can improve schizophrenia symptoms such as hallucinations and delusions, but do not affect the symptoms most closely correlated with real-world functioning (cognitive and negative symptoms). An improved understanding of how neuroinflammation contributes to the pathophysiology of schizophrenia could lead to a) novel treatments for cognitive and negative symptoms, b) identification of biomarkers that could help guide future treatment, and c) foundation for a personalized medicine approach to the treatment of schizophrenia, including utilization of anti-inflammatory and antioxidant treatment. These developments may, in turn, improve the vocational, housing, and social situation of Veterans and others with schizophrenia. !

PI_NAMEs: YANG, YVONNE S (contact)

PROJECT_TERMS: Address;Affinity;Anti-Inflammatory Agents;Antioxidants;Area;Autopsy;Award;Binding;Binding Proteins;Biological Markers;biomarker identification;Brain;brain based;Cells;Cerebrospinal Fluid;Clinical assessments;clinically relevant;Cognition;Cognitive;cognitive function;cognitive performance;Communication;Communities;cytokine;Cytoprotection;Delusions;Development;disability;Educational workshop;Enzymes;Exclusion;Foundations;Free Radicals;Functional disorder;functional outcomes;Future;Generations;Genotype;Glutathione;Goals;Hallucinations;Housing;Immune;improved;Inflammation;Inflammatory;inflammatory marker;Injury;Interleukin-10;Interleukin-6;Interview;K-Series Research Career Programs;Knowledge;Lead;Light;Link;Magnetic Resonance Spectroscopy;Maps;Measurement;Measures;meetings;Mentors;Microglia;Mitochondria;Natural Immunity;Neuroglia;neuroimaging;neuroinflammation;Neurons;Noise;novel;Occupational Status;Outcome;Oxidative Stress;Pathogenesis;Patients;Peripheral;peripheral blood;personalized medicine;Phenotype;Plasma;Positron-Emission Tomography;Pre-Clinical Model;Prefrontal Cortex;Process;Production;Proteins;Psychiatrist;Psychoneuroimmunology;Psychotic Disorders;Quality of life;radioligand;Reactive Oxygen Species;recruit;Reporting;response to injury;responsible research conduct;Role;Sample Size;Schizophrenia;Signal Transduction;skills;social relationships;social situation;Specificity;symposium;Symptoms;System;Techniques;Testing;Tissues;TNF gene;Training;United States Department of Veterans Affairs;Veterans;Vocation;Work

PROJECT_TITLE: Neuroinflammation and Oxidative Stress in Veterans with Schizophrenia


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project narrative The locus coeruleus is the brain’s major source of the neuromodulator norepinephrine and is one of the first regions to be affected by the accumulation of abnormal tau, a neuropathological hallmark of Alzheimer’s disease. We propose individuals combat insults to locus coeruleus by increasing rates of norepinephrine synthesis. We will investigate the relationship between norepinephrine synthesis capacity and underlying locus coeruleus structure, and the possible role of elevated norepinephrine synthesis in cognitive resilience and resistance to the spread of tau pathology.

PI_NAMEs: BERRY, ANNE SHIVELY (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amygdaloid structure;Amyloid;Animal Model;Anti-Inflammatory Agents;Arousal;Attention;Autopsy;Binding;biomarker development;Blood;Blood - brain barrier anatomy;Brain;Brain Stem;Cell Density;Cell Nucleus;Cells;Cerebrospinal Fluid;Chemicals;Child;Cognition;Cognitive;cognitive function;combat;Compensation;Data;Development;Disease;Disease Progression;Disease Resistance;Dopamine;Early Intervention;entorhinal cortex;Enzymes;financial incentive;healthy aging;Hippocampus;Human;human old age (65+);hyperphosphorylated tau;imaging biomarker;Impaired cognition;in vivo;Individual;Individual Differences;insight;interest;Investigation;Lesion;Link;locus ceruleus structure;Magnetic Resonance Imaging;Maintenance;Measures;medial temporal lobe;Mediating;Memory;memory encoding;Memory impairment;Memory Loss;Metabolism;Methods;mild cognitive impairment;mouse model;multimodality;Nerve Degeneration;neurobiological mechanism;neurochemistry;Neuromodulator;Neurons;neuropathology;neuroprotection;neuroregulation;Norepinephrine;norepinephrine system;novel;older adult;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Performance;Persons;Plasma;Positron-Emission Tomography;prevent;Process;Reporting;Research;resilience;Resistance;resistance mechanism;response;Rodent Model;Role;sleep regulation;Source;Standardization;Structure;Targeted Research;tau aggregation;tau mutation;tau Proteins;Temporal Lobe;Testing;theories;Tracer;transmission process;Tyrosine;Up-Regulation;uptake;ward;young adult

PROJECT_TITLE: Upregulated Norepinephrine Synthesis Capacity in Aging

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE We will leverage existing biomarker data to derive new polygenic risk scores (PRS) to improve prediction of disease across ancestrally diverse populations, particularly focusing on inflammation and hematological measures under selective pressure from differential infectious disease exposures. We will develop high quality PRS for common laboratory measures that differ in means and/or variances by ancestry, which would enable improved diagnostic accuracy and reduce unnecessary repeat testing and downstream healthcare utilization.

PI_NAMEs: COX, NANCY J;LI, YUN  (contact);REINER, ALEXANDER P

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Accounting;Affect;African American;African American population;Alleles;APOL1 gene;Asian Americans;Asian population;Biological Assay;Biological Markers;Biology;Blood Cells;Blood Platelets;C-reactive protein;Calibration;chemokine receptor;Chronic Disease;Chronic Kidney Failure;Clinical;clinical biomarkers;clinical care;cohort;Communicable Diseases;Data;data harmonization;Data Set;Diagnosis;diagnostic accuracy;Disease;Disease Pathway;Disease Progression;Disease susceptibility;disorder risk;Disparity;DNA;endophenotype;Erythrocytes;European;European ancestry;Fibrin fragment D;Fibrinogen;Frequencies;Gene Frequency;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide analysis;Genotype;Goals;Health;health care delivery;health care service utilization;health disparity;Healthcare;Hematology;Heritability;Hispanic;human disease;Immune;Immune response;improved;in silico;Individual;Inflammation;Inflammatory;inter-individual variation;Jackson Heart Study;Joints;Laboratories;Latino;Leukocytes;lifetime risk;Linkage Disequilibrium;Measures;Mendelian disorder;method development;Modeling;Monitor;Mutation;Native American Ancestry;Natural Selections;novel;Outcome;pathogen;Pathway interactions;Performance;personalized medicine;Phenotype;phenotypic data;polygenic risk score;Population;Population Genetics;Population Heterogeneity;Population Sizes;predictive modeling;Predisposition;pressure;Property;Research Methodology;Risk Estimate;risk variant;Role;Sample Size;Scoring Method;Sickle Cell Anemia;Sickle Hemoglobin;Site;Susceptibility Gene;Testing;thrombotic;trait;Variant;Weight;White Blood Cell Count procedure;Women's Health

PROJECT_TITLE: Polygenic risk scores and health disparities: the role of blood cells immune response and evolutionary adaptation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Our overarching goal is to employ advanced molecular positron emission tomography (PET) imaging to quantify the temporal kinetics of T-cell activation and infiltration during novel combination intratumoral oncolytic herpes simplex virus (oHSV) immunotherapy in preclinical models of glioblastoma (GBM). Imaging the kinetics of CD8 cell and granzyme B in the tumors during combination therapies will help enhance the therapeutic efficacy of targeted IL-12 and IL-18 oHSV, optimize therapies on a personalized basis, and extend overall survival.

PI_NAMEs: MARKERT, JAMES M;SORACE, ANNA C (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: anti-tumor immune response;Biological;Biological Assay;Biopsy;booster vaccine;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Cycle Kinetics;cell transformation;Cells;Characteristics;Clinical;combinatorial;Combined Modality Therapy;Cytolysis;Data;Disease Progression;Dose;Flow Cytometry;Glioblastoma;Glioma;Goals;Granzyme;Heterogeneity;Human;IL18 gene;Image;imaging modality;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immune response;Immunofluorescence Immunologic;Immunologic Stimulation;Immunologics;ImmunoPET;immunoregulation;Immunotherapy;improved;in vivo;Infection;Infiltration;Inflammation;insight;Interleukin-12;Kinetics;Knowledge;Laboratories;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of brain;Measures;Modeling;Molecular;molecular imaging;mouse model;Mus;neoplastic cell;novel;oncolytic herpes simplex virus;Patient Selection;Patients;Phase I Clinical Trials;Positron-Emission Tomography;pre-clinical;Pre-Clinical Model;predicting response;Prediction of Response to Therapy;programmed cell death ligand 1;programmed cell death protein 1;Proteins;quantitative imaging;Radiation;Radiation therapy;Regimen;response;serial imaging;Signal Transduction;Solid Neoplasm;synergism;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;transcriptomics;Treatment Efficacy;treatment optimization;treatment response;tumor;Tumor Antigens;Tumor Volume;Validation;Viral Antigens;Virus;Visualization

PROJECT_TITLE: Utilization of Immuno-PET to detect response and guide novel oHSV-based therapy for glioma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative For this work, we will employ a variety of biochemical and biophysical tools to elucidate the molecular mechanisms by which two different protein families transport ions across biological membranes. Specifically, KdpFABC actively pumps potassium into bacterial cells in order to maintain turgor pressure, whereas YiiP exports zinc and belongs to a large class of proteins that control the distribution of transition metal ions. Our goal is to combine structural studies with functional analyses to develop a comprehensive understanding of the reaction cycle governing the transport process.

PI_NAMEs: STOKES, DAVID L. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Adopted;animation;antiporter;Architecture;ATP phosphohydrolase;Behavior;Binding;Binding Sites;Biochemical;biochemical tools;Biological;Biological Assay;biophysical tools;Biophysics;Cartoons;Cations;Cells;Coupling;Cryoelectron Microscopy;Diffusion;Elements;Family member;Goals;Homeostasis;Hybrids;In Vitro;Individual;interest;Investigation;Ion Transport;Ions;Laboratories;Light;Maps;Membrane;Molecular;Molecular Conformation;molecular dynamics;Molecular Machines;mutant;Na(+)-K(+)-Exchanging ATPase;Nature;novel;novel strategies;Pathway interactions;Potassium Channel;pressure;Process;Protein Dynamics;Protein Family;Proteins;Protons;Pump;Reaction;Role;simulation;single-molecule FRET;Site;Structure;Substrate Specificity;System;Thermodynamics;Transition Elements;Transport Process;Travel;Work;Zinc

PROJECT_TITLE: Molecular Mechanisms of Ion Transport

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Overall: Project Narrative The UCLA-CDU CFAR is located in metropolitan Los Angeles, which is a major epicenter for the AIDS epidemic, and is the most populous county in the nation, ranking second in the number of documented cases of advanced HIV disease. The UCLA-CDU CFAR seeks to catalyze and expand HIV research by providing the infrastructure to connect, support and enhance the capacity of investigators affiliated with UCLA and CDU. The UCLA-CDU CFAR will strengthen and amplify the impact of existing research activities and launch new partnerships across Los Angeles and globally through our focus on three themes: we will STOP HIV by preventing new HIV infections (Prevention), reducing morbidity among people living with HIV (Treatment) and developing strategies for eradication (ART-free Remission).

PI_NAMEs: CURRIER, JUDITH S.;SPENCER, LASHONDA ;ZACK, JEROME A. (contact)

PROGRAM_OFFICER_NAME: REFSLAND, ERIC WILLIAM

PROJECT_TERMS: Accreditation;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Animal Model;Area;Award;Behavioral;behavioral study;biobank;Biological Assay;California;career;Clinic;Clinical;Clinical Informatics;Clinical Laboratory Improvement Amendments;Clinical Research;Clinical Sciences;Clinics and Hospitals;Collaborations;Communication;Communities;community advisory board;community based participatory research;community based research;community engagement;community partners;cost effective;County;Data;design;Development;Disease;Disease remission;Ensure;Epidemic;Equipment;Equity;Faculty;Funding;gene therapy;Goals;Grant;health equity;Healthcare Systems;HIV;HIV Infections;HIV/AIDS;humanized mouse;Incubators;Inequity;Informatics;Infrastructure;Institution;Interdisciplinary Study;Laboratories;Leadership;Link;Los Angeles;Medical center;meetings;member;Mentors;metropolitan;Mission;Morbidity - disease rate;multidisciplinary;Neighborhoods;next generation;Participant;Pathogenesis;Persons;Pilot Projects;Policies;Population;prevent;Prevention;Procedures;Productivity;programs;Provider;Public Health Informatics;recruit;Registries;Regulation;Research;Research Activity;Research Personnel;research study;Resources;Sampling;Science;Scientist;Services;Shapes;Site;social;Structure;substance use;success;symposium;Talents;Techniques;Training;Training Activity;Translational Research;United States National Institutes of Health;Universities;working group

PROJECT_TITLE: UCLA-CDU CFAR


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Congenital Structural Anomalies;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Rare Diseases

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: The goal of this project is to characterize the molecular, cellular and pathophysiological mechanisms of a class of renal cancers driven by the Folliculin-TFEB signaling pathway. We will test the hypothesis that dysregulated mTORC1 is a key driver of renal cancers triggered by Folliculin deletion and TFEB translocation.

PI_NAMEs: BALLABIO, ANDREA ;ZONCU, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Autophagocytosis;Binding;Biochemical;Biogenesis;Biological Assay;Birt-Hogg-Dube Syndrome;Catabolic Process;Cell Differentiation process;Cell Separation;Cells;Cellular biology;Cellular Metabolic Process;Chromosomal translocation;Complex;Coupled;Coupling;CRISPR screen;Cultured Cells;Cystic kidney;detection of nutrient;Disease;disease phenotype;Evaluation;Evolution;Feedback;Folliculin;FRAP1 gene;Genetic Screening;Goals;Growth;Growth Factor;Guanosine;Hereditary Disease;Histologic;Homeostasis;Hyperactivity;in vivo;inhibitor;Kidney;kidney cell;Kidney Neoplasms;Knockout Mice;Link;lipid biosynthesis;Lysosomes;Malignant Neoplasms;Malta;Mediating;Metabolic;Metabolic Pathway;Modeling;Molecular;mouse model;Mus;Mutation;Names;Nature;nephrogenesis;novel;novel strategies;Nuclear;Nucleotides;Nutrient;Oncogenic;overexpression;Pathogenesis;Pathologic;Pathology;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;Physiology;Play;Polycystic Kidney Diseases;Process;programs;Proliferating;Protein Biosynthesis;Proteomics;Recycling;Regulation;Renal Carcinoma;Renal Cell Carcinoma;Renal Tissue;Reporter;Research;response;Role;Science;Signal Pathway;Signal Transduction;Sorting;Stimulus;Structure;Testing;TFE3 gene;Therapeutic;transcription factor;Transcriptional Activation;Transcriptional Regulation;transcriptomics;Transgenic Mice;Transgenic Model;Tuberous Sclerosis;tumor growth;Tumor Suppressor Proteins;tumorigenesis

PROJECT_TITLE: Dissecting and targeting lysosomal signaling in kidney tumorigenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative: This project will systematically identify substrates and functions of calcineurin, which regulates many processes in humans by mediating Ca2+-dependent changes in protein phosphorylation. Misregulation of calcineurin underlies immune disorders, diabetes, cancer, heart disease and epilepsy. This research studies calcineurin function at a biochemical and structural level and will provide new insights into its actions in healthy and diseased cells, thus uncovering new therapeutic approaches to control its activities selectively.

PI_NAMEs: CYERT, MARTHA S. (contact)

PROJECT_TERMS: adaptive immune response;Address;Affinity;Bar Codes;Biochemical;Biotin;C-terminal;Calcineurin;Calcineurin inhibitor;calcineurin phosphatase;Calmodulin;Cardiovascular system;Cell Physiology;Cells;Centrosome;Coupled;Cyclosporine;Diabetes Mellitus;Disease;Enzymes;Epilepsy;Eukaryota;Explosion;FK506;Future;Heart Diseases;Human;Hypertension;Immune system;Immune System Diseases;Immunosuppressive Agents;in silico;in vivo;insight;Knowledge;Label;Ligase;Location;Malignant Neoplasms;Maps;Mediating;Membrane;Methods;Microspheres;Nervous System;new technology;novel strategies;novel therapeutic intervention;nuclear factors of activated T-cells;Nuclear Pore Complex;palmitoylation;Peptides;Pharmaceutical Preparations;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Play;Process;protein aminoacid sequence;Protein Dephosphorylation;Protein Isoforms;Protein Kinase;Protein phosphatase;Proteins;ratiometric;Regulation;Research;research study;Role;Saccharomyces cerevisiae;Seizures;sensor;Signal Pathway;Signal Transduction;Tissues;transcription factor;Work

PROJECT_TITLE: Systematic elucidation of calcineurin phosphatase signaling in humans

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Bioengineering

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE  Mechanical signaling is critical in development and immune function, and its dysfunction has been implicated in numerous malignancies, including cancer and cardiomyopathies. This project aims to reveal how forces alter the structure of actin filaments, the major load-bearing element of the cell. Our studies will establish basic principles of how forces alter protein structure to transmit mechanical signals, which in the long-term will guide the development of therapeutics targeting these processes.

PI_NAMEs: ALUSHIN, GREGORY M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 3-Dimensional;Actin-Binding Protein;Actins;Adhesions;alpha catenin;Architecture;Binding;Binding Proteins;Bioinformatics;Biological Assay;Biophysics;Body part;calponin;cancer cell;Cardiomyopathies;cell behavior;cell motility;Cell Physiology;Cells;Chemical Structure;Chemicals;cofilin;comparative;completed suicide;Cryo-electron tomography;Cryoelectron Microscopy;Cues;Cytoskeleton;Data;deep learning;design;detector;Development;Disease;Drug Design;drug development;drug discovery;Drug Targeting;Elements;Environment;Event;Exposure to;Filament;flexibility;fluid flow;Functional disorder;Goals;Health;human disease;Image Analysis;immune function;in vivo;insight;Intervention;knowledgebase;macromolecular assembly;Malignant Neoplasms;mechanical force;mechanical signal;Mechanics;mechanotransduction;Microfilaments;migration;Modeling;Molecular;Molecular Conformation;Molecular Motors;Motor;Motor Activity;mutant;Mutation;Myosin ATPase;network architecture;Outcome;Pathway interactions;Physiological;Polymers;Preparation;Process;protein function;Protein Region;protein structure;Proteins;Proteome;receptor;reconstitution;Regulation;Research Project Grants;Resolution;Role;Sampling;Series;Signal Pathway;Signal Transduction;Signaling Protein;Structure;Surface;System;Testing;Therapeutic;therapeutic development;therapeutic target;three dimensional structure;three-dimensional visualization;transmission process;Vinculin;Visualization;Weight-Bearing state

PROJECT_TITLE: Structural Mechanisms of Cytoskeletal Force-Sensing

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Autoimmune Disease;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: This proposal is significant as our research is designed to advance our understanding how telomere shortening changes the absorptive cells in the intestine, enterocytes. We will establish how these changes in these cells predispose to intestinal inflammation.

PI_NAMEs: SAHIN, ERGUN  (contact);SHROYER, NOAH FREEMAN

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: absorption;Acceleration;Address;Age;age-related disease;Apoptosis;Atrophic;Automobile Driving;Biology;Biopsy;Caco-2 Cells;Cell Differentiation process;Cell Line;Cell Lineage;Cells;cellular microvillus;Colitis;Consumption;coping;Crohn's disease;Defect;design;Development;Diet;Disease;DNA Damage;Enterocytes;Enzymes;Epithelium;Exposure to;Fructokinases;Fructose;Functional disorder;Generations;Genes;Genetic;gut inflammation;HNF4A gene;Human;Impairment;improved;induced pluripotent stem cell;Inflammation;Inflammatory Bowel Diseases;intestinal barrier;Intestinal Diseases;Intestines;Knockout Mice;Knowledge;Length;Maintenance;Malabsorption Syndromes;Malignant Neoplasms;Measures;Mediating;Metabolic stress;Mitochondria;mitochondrial dysfunction;mortality;mouse model;multilevel analysis;Mus;Mutation;normal aging;novel;old mice;Older Population;Organoids;Pathogenesis;Pathogenicity;Pathology;patient population;Patients;Phenotype;Play;Predisposition;preservation;prevent;Prevention;Prognostic Marker;Proteins;Proteomics;Relapse;Repression;Research;response;Risk;risk stratification;Role;Scanning Electron Microscopy;senescence;Small Intestines;Source;stem;stem cell exhaustion;stem cell self renewal;stem cells;Structure;sugar;Supplementation;System;Systemic disease;Telomerase;telomere;Telomere Shortening;Testing;Therapeutic;Time;Tissues;Toxic effect;TP53 gene;transcription factor;transcriptome sequencing;Transmission Electron Microscopy;treatment stratification;Ulcerative Colitis

PROJECT_TITLE: Mechanisms of telomere-induced disease: Role of intestinal malabsorption, barrier dysfunction and dsybiosis.

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Methamphetamine;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Rural Health;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Recent studies indicate that use of methamphetamine among those using opioids (coined the “twin epidemics) is on the rise. This study seeks to understand the impact of methamphetamine use on drug-related harms (injection, overdose, HIV/HCV/STI) and SUD treatment enrollment in rural areas that are enmeshed in the opioid epidemic. To this end, we will collect prospective data from two extant, NIDA-funded cohorts of rural people who use drugs and this proposed renewal will address gaps in our knowledge of the twin epidemics of methamphetamine and opioid use and provide data that are integral to addressing drug-related harms in the rural U.S.

PI_NAMEs: HAVENS, JENNIFER R (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Address;Appalachian Region;Area;barrier to care;Behavioral;cohort;Cohort Studies;Coin;Collection;combat;Complement;Data;Data Collection;Death Certificates;disease transmission;dosage;Drug user;Enrollment;Epidemic;Evidence based treatment;follow-up;Funding;Geography;Goals;Harm Reduction;harm reduction programs;Health Personnel;Hepatitis C virus;HIV;HIV/HCV;Injections;Intervention;Kentucky;Knowledge;Length of Stay;Literature;Location;Manuscripts;Measures;Methamphetamine;Methamphetamine overdose;methamphetamine use;Methamphetamine use disorder;Modality;Modeling;National Institute of Drug Abuse;Needle Sharing;Opioid;opioid epidemic;opioid injection;opioid use;opioid use disorder;opioid user;Outcome;Overdose;overdose death;Participant;Pathway Analysis;Patient Self-Report;Pattern;Persons;Pharmaceutical Preparations;Policies;Positioning Attribute;prescription opioid;programs;prospective;Publications;Publishing;recruit;Reporting;Resources;Risk;Risk Behaviors;Route;Rural;Rural Appalachia;rural area;Rural Community;Rural Population;Sample Size;Sampling;Services;sex;sexual encounter;sexual risk behavior;Social Network;stimulant use;substance use;Substance Use Disorder;substance use treatment;Testing;therapy development;Time;treatment disparity;treatment program;treatment services;Twin Multiple Birth;Unsafe Sex;Work

PROJECT_TITLE: Examining the Impact of the Twin Epidemics of Methamphetamine and Opioid Use on Overdose, Risky Sex and Treatment Engagement among PWUD in Two Rural Appalachian Cohorts

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

ORG_CITY: ATHENS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OHIO UNIVERSITY ATHENS

PHR: Project Narrative The proposed research is relevant to public health because it will advance the understanding of the physiological mechanisms of weakness in older adults. Weakness is a major risk factor for the development of physical disability in old age. As such, this application is highly relevant to NIH’s mission of extending healthy living and reducing the burdens of physical disability in old age.

PI_NAMEs: ARNOLD, WILLIAM DAVID;CLARK, BRIAN C (contact);ELBASIOUNY, SHERIF M

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Action Potentials;Age;Age Months;age related;age-related muscle weakness;Aging;Animal Experiments;Animals;base;biomarker development;Calcium-Activated Potassium Channel;calcium-activated potassium channel small-conductance;Cell membrane;Clinical;cohort;Communities;Cross-Sectional Studies;Data;Development;Disease;early detection biomarkers;Exhibits;experience;experimental study;Extensor;frailty;Functional disorder;Goals;Human;human data;human old age (65+);Immunohistochemistry;In Situ;In Vitro;in vivo;Incidence;Intervention;Ion Channel;Knowledge;Leg;Measures;Membrane;Mission;Molecular;Motor;Motor Neurons;Mus;Muscle;Muscle Fibers;muscle form;Muscle function;muscle strength;Muscular Atrophy;National Institute on Aging;Neurologic;neuromechanism;neuronal excitability;old mice;older adult;physical impairment;physically handicapped;Physiological;Play;Preparation;prevent;protein expression;Public Health;Research;Research Design;Risk Factors;Role;sarcopenia;Sensory;Series;sex;Spinal Cord;Testing;Time;timeline;United States National Institutes of Health;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Motoneuronal mechanisms underlying age-related muscle weakness

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The progressive myoclonus epilepsies (EPM) are a class of genetically-determined neurological disorders defined by onset in previously healthy individuals of tremor, seizures, and ataxia, advancing relentlessly to loss of ambulation, chronic epilepsy and myoclonus, and early death. EPM is without cure or disease-altering treatment, yet advances in neurogenetics may inform novel therapeutic approaches. Here, we have generated a new experimental animal model of an EPM and propose to define cellular and circuit mechanisms of disease and treat the disorder using targeted pharmacotherapy that may be translatable to the clinical arena.

PI_NAMEs: GOLDBERG, ETHAN M (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Acute;Ataxia;biophysical properties;Biophysics;Brain;Calcium;Caring;Case Study;Cells;Cerebellar Diseases;Cerebellum;Cerebral cortex;Cessation of life;Child;Chronic;Clinical;clinical phenotype;Cognitive;cohort;Collaborations;comorbidity;Data;de novo mutation;Defect;Dependence;Deterioration;Development;Disease;disease-causing mutation;early onset;Electrophysiology (science);Epilepsy;epileptic encephalopathies;Exhibits;Experimental Animal Model;Experimental Models;experimental study;Fire - disasters;Frequencies;Functional disorder;Funding;gene function;Gene Targeting;Genes;Genetic;genetic disorder diagnosis;Genetic Predisposition to Disease;Genetic Variation;Goals;granule cell;Heterozygote;Hindlimb;Home;Human;Image;improved;In Vitro;in vivo;indexing;Individual;induced pluripotent stem cell;insight;Institution;Intellectual functioning disability;Interneurons;Ion Channel;Knock-in Mouse;Link;Location;loss of function;Measures;Medical Genetics;Modeling;mouse model;Mus;Myoclonus;Neocortex;neocortical;Nervous System Disorder;neurogenetics;Neurologic Dysfunctions;Neurons;novel;novel therapeutic intervention;novel therapeutics;Parvalbumins;patch clamp;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Performance;pharmacologic;Pharmacotherapy;Phenocopy;Physiological;Physiology;pre-clinical;Pre-Clinical Model;precision medicine;Predisposition;Preventive measure;Progressive Myoclonic Epilepsies;Property;Purkinje Cells;Pyramidal Cells;Reagent;Recurrence;Research;Role;Seizures;Severities;Shaw potassium channel protein family;Slice;Synapses;Synaptic Transmission;System;targeted treatment;Testing;therapy development;tool;Translating;Tremor;United States National Institutes of Health;Variant;voltage clamp;Voltage-Gated Potassium Channel;Walking;Wheelchairs;Work;young adult

PROJECT_TITLE: Mechanistically-oriented therapy for a progressive myoclonus epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Genetics

ORG_CITY: COLLEGE STATION

ORG_DEPT: CHEMISTRY

ORG_NAME: TEXAS A&M UNIVERSITY

PHR: PROJECT NARRATIVE  The major goal of the current application is to understand functions of posttranslational lysine modifications in the regulation of chromatin, polyubiquitination functions, and cyclic GMP-AMP synthase. The project is relevant to public health and the NIH’s mission in promoting health and combating diseases because it will reveal the molecular basis of chromatin and cyclic GMP-AMP synthase regulation by posttranslational lysine modifications and assist in the identification of therapeutics that target chromatin and cyclic GMP-AMP synthase modifications.

PI_NAMEs: LIU, WENSHE RAY (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Academia;Address;Amber;Amino Acids;Amino Acyl-tRNA Synthetases;Binding;Biological;biological research;Biology;Cells;Charge;Chemicals;Chromatin;Codon Nucleotides;Complex;Cryoelectron Microscopy;Cyclic GMP;Disease;ds-DNA;Engineering;Enzymes;Epigenetic Process;Eukaryotic Cell;Genetic;Goals;Half-Life;HDAC1 gene;Health Promotion;Histones;Human;Industry;Innate Immune Response;KDM1A gene;Lysine;Mass Spectrum Analysis;Methods;Mission;Modification;Molecular;Mutagenesis;mutant;novel;Nucleosomes;pathogen;Polyubiquitination;Post-Translational Regulation;Prokaryotic Cells;Protein Biosynthesis;Protein Isoforms;Proteins;Proteomics;Public Health;pyrrolysine;reconstitution;Regulation;Research;Role;sensor;Site;System;Techniques;therapeutic target;tool;Ubiquitin;Ubiquitin Like Proteins;United States National Institutes of Health

PROJECT_TITLE: Use of the Noncanonical Amino Acid Mutagenesis Technique in Combination with Other Approaches to Study Functions of Posttranslational Lysine Modifications in Proteins


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proper wiring of the cerebral cortex in humans is essential for the performance of a variety of complex behaviors. Disrupted cortical wiring leads to a number of neurodevelopmental disorders including autism spectrum disorders and intellectual disability. Understanding genetic programs that dictate how neurons and astrocytes coordinate their activities during circuit formation will provide important insight for the development of therapeutic interventions.

PI_NAMEs: HARWELL, COREY C (contact);LEE, WEI-CHUNG ALLEN

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Ablation;Astrocytes;autism spectrum disorder;Behavior;Biological Assay;Brain;Brothers;Cell Adhesion Molecules;cell behavior;Cell Physiology;cell type;Cerebral cortex;Chemical Synapse;Communication;Complement;Complex;cytokine;Data;Development;Electrical Synapse;Electron Microscopy;Electrophysiology (science);experimental study;Gene Expression;Genes;Genetic;Genetic Transcription;GLI gene;Histology;Homeostasis;Human;insight;Intellectual functioning disability;Ions;light microscopy;loss of function;Maintenance;Mediating;Molecular;mouse genetics;mutant;Nature;Nervous System;neural circuit;Neurodevelopmental Disorder;Neuroglia;Neurons;Neurophysiology - biologic function;neurotransmitter reuptake;Pathway interactions;Performance;Play;Process;programs;Proteins;Publishing;receptor;Regulation;response;Role;SHH gene;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Specific qualifier value;Specificity;Synapses;synaptic function;synaptogenesis;Testing;therapeutic development;Therapeutic Intervention;tool;Work

PROJECT_TITLE: Sonic Hedgehog Dependent Neuron-Astrocyte Crosstalk During Cortical Circuit Assembly

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Eye Disease and Disorders of Vision;Fragile X Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The overall goal of this proposal is to determine, at the circuit and systems level, the role of visual familiarity- evoked oscillations in predictive behavior in wild type and Fmr1 KO mice, a model of Fragile X Syndrome. We will perform extracellular recordings with Neuropixels probes in V1 and ACC of awake mice, use optogenetics in combination with behavior to determine the relationship between oscillations and visual learning. We will map the underlying neural circuit responsible for these oscillations and impaired in Fmr1 KO mice.

PI_NAMEs: CHUBYKIN, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Anatomy;Anterior;Area;area striata;ASD patient;autism spectrum disorder;awake;Behavior;behavior prediction;Behavioral;Brain;cell type;cingulate cortex;Code;Computer Models;Cortical Cell Layer;Cues;Data;data modeling;Decision Making;Detection;Development;diagnostic criteria;discrimination task;Electrophysiology (science);Elements;Event;expectation;experience;extracellular;Familiarity;feasibility research;FMR1 gene;Fragile X Syndrome;Frequencies;Funding;Future;Generations;Goals;Grant;Human;Impairment;In Vitro;in vivo;individuals with autism spectrum disorder;information processing;Intellectual functioning disability;Interneurons;Learning;Learning Disabilities;Life;Link;Maps;Measures;model of autism spectrum disorder;Modeling;mouse model;Mus;neocortical;neural;neural circuit;neuromechanism;Neurons;novel;optogenetics;Outcome;Patients;Pattern;personalized medicine;pharmacologic;Process;Publications;Reporting;Research;restoration;Role;selective expression;Sensory;sensory stimulus;Short-Term Memory;Slice;social communication;Social Interaction;Stimulus;Synapses;Synaptic plasticity;synaptogenesis;System;Therapeutic;therapeutic target;Time;Visual;visual discrimination;visual learning;Visual Perception

PROJECT_TITLE: Neural Mechanisms of Predictive Impairments in Autism

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Microbiome

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: RELEVANCE (See instructions): Our proposed work continues to be fundamentally basic research on the cholesterol-dependent cytolysins but which often leads to translational applications (i.e., vaccines) and supports the efforts in the field of pathogenesis where these toxins contribute to disease. These studies have led us to the discovery of a large class of ancient CDC relatives that have spread throughout the Bacteria kingdom and are present in many major species of the human microbiome. Finally, these studies will reveal the molecular mechanism of a unique class of anti-bacterial toxins, which could potentially be used in therapies for infections.

PI_NAMEs: TWETEN, RODNEY K. (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TITLE: Pore Formation by Cholesterol Dependent Cytolysins

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE K+ channels are membrane proteins that allow rapid and exquisite selective flow of K+ ions across the cell membrane that is crucial to generate chemical and electrical activities in living cells, and their dysfunction lead to many human diseases. To completely understand the behavior of ion channels, dynamic views of the structures are essential to fill the gap between crystal/CryoEM structures and single ion channel current analyses. The structural dynamics of potassium channel proteins presents an exciting and emerging field of study which will provide new understanding of the fundamental basis of channel function.

PI_NAMEs: MATAMOROS CAMPOS, MARCOS  (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Action Potentials;Address;Adopted;Amino Acids;Arrhythmia;Axon;Behavior;Biophysics;Cell membrane;Cells;Charge;Chemicals;Complex;constriction;Cryoelectron Microscopy;Cytoplasm;Data;design;Development;Disease;Drug Design;Electrophysiology (science);Environment;experience;experimental study;extracellular;Family;field study;flexibility;Fluorescence Resonance Energy Transfer;Functional disorder;Generations;Goals;Health;human disease;Image;Inflammation;insight;Integral Membrane Protein;interest;Ion Channel;ion dynamics;Ions;Label;Lead;Life;Local Anesthetics;Malignant Neoplasms;Mechanical Stress;Membrane Lipids;Membrane Proteins;Mentors;Methods;Migraine;Modeling;Molecular;Molecular Conformation;molecular dynamics;Movement;Mutation;nanobodies;non-Native;novel strategies;novel therapeutics;Organism;Pain;Pathologic;Pathology;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;Physiological;Play;Positioning Attribute;Potassium;Potassium Channel;pressure;Protein Dynamics;Proteins;Regulation;Research;Research Personnel;Resolution;Role;Signal Transduction;single molecule;single-molecule FRET;skills;Structural Biologist;Structure;Techniques;Temperature;Testing;therapeutic target;Time;Tissues;tool;Training;Transmembrane Domain;voltage;Work

PROJECT_TITLE: K+ channel structural dynamics landscape: from selectivity to gating


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STORRS-MANSFIELD

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: The study will examine the mechanism of release of autocrine factors that are essential for oligodendrocyte production and how it is influenced by neuronal signals. The critical autocrine factors will be identified by mass spectrometry. The outcome of the study can be used to design novel strategies to promote oligodendrocyte differentiation, survival, and myelination during repair of demyelinating conditions.

PI_NAMEs: NISHIYAMA, AKIKO  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Acute;Affect;Apoptosis;autocrine;Autocrine Communication;Axon;axonal degeneration;Binding;Botulinum Toxins;Cause of Death;Cell Communication;Cell Lineage;Cell membrane;Cell Nucleus;Cell Proliferation;cellubrevin;Cessation of life;Chronic;Complex;Demyelinating Diseases;Demyelinations;density;design;Development;Event;Exhibits;Exocytosis;Failure;Functional disorder;Generations;Genetic;Image;In Vitro;in vivo;Knowledge;Lesion;Life;Mass Spectrum Analysis;Mediating;Mitochondria;Molecular;Multiple Sclerosis;Mus;Myelin;myelination;Natural regeneration;neural;Neurologic Deficit;Neurons;neurotransmission;neurotransmitter release;novel;novel strategies;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;optogenetics;Outcome Study;Persons;Play;precursor cell;preservation;presynaptic neurons;Presynaptic Terminals;Process;Production;programs;Proteins;Proteomics;receptor;remyelination;repaired;response;Role;Scheme;Series;Signal Transduction;single-cell RNA sequencing;SNAP receptor;Synapses;Synaptic Vesicles;Testing;Transcript;Transgenic Mice;VAMP-2;Vesicle;vesicle-associated membrane protein;white matter

PROJECT_TITLE: SNARE complex-mediated exocytosis in oligodendrocyte differentiation and survival


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Prevention;Rare Diseases;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE One in 151 women in the United States carry the FMR1 premutation, a genetic abnormality that is associated with substantially increased risk for disease that appears to worsen at older ages. This longitudinal investigation of mother carriers of the FMR1 premutation aims to define age-related stability of symptoms in midlife and early old age, associated functional limitations, and the role of biological and environmental factors. Delineating the trajectory and predictors of age-related decline will inform critical age periods for prevention, risk factors, and the eventual development of strategies to improve age-related outcomes for both carrier mothers and their children with fragile X syndrome.

PI_NAMEs: KLUSEK, JESSICA  (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adopted;Adult;Advocate;Affect;Age;age acceleration;age related;age related changes;age related decline;aged;Aging;aging process;Anxiety;Autoimmune;Autonomic Dysfunction;Autonomic nervous system;Biological;Biological Factors;Caring;Characteristics;Child;Child Rearing;chronic painful condition;Classification;Clinical;Clinical Management;clinical risk;Cross-Sectional Studies;Data;Development;disability;disorder risk;DNA Sequence Alteration;Environmental Risk Factor;Executive Dysfunction;executive function;experience;Eye;Family;FMR1 gene;FMR1 Premutation;Fragile X Syndrome;Functional disorder;Future;Gene Abnormality;Genes;Genetic;Genetic Predisposition to Disease;Genotype;Glean;Goals;Growth;Heart Rate;High Prevalence;human old age (65+);Impairment;improved;improved outcome;Individual;Infertility;innovation;International;Investigation;Life;Long-Term Effects;longitudinal design;men;Mental Depression;Mental Health;Messenger RNA;middle age;Modeling;Molecular Abnormality;Molecular Genetics;Mothers;Mutate;mutation carrier;Neurodegenerative Disorders;Outcome;Parents;Phenotype;Physiological;premature;Premature Menopause;Prevention;Public Health;respiratory;Risk;Risk Factors;Role;Sinus Arrhythmia;social;social communication;social deficits;social skills;Statistical Methods;Stress;stressor;Symptoms;Testing;Time;United States;Woman;Work

PROJECT_TITLE: Aging Symptom Trajectories in Mother Carriers of the FMR1 Premutation

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


PHR: Project Narrative When cells in a developing animal grow to form tissues and organs, they often do so in response to concentration gradients of chemical signals. The mechanisms by which these molecular messages move and are received has been in question, but research proposed in this application explores the structure and function of cytonemes - thin, finger-like protrusions from cells that play a key role in this process. Our findings will have important implications for cell-cell signalling in normal development and in many disease contexts, including viral infections and cancer.

PI_NAMEs: KORNBERG, THOMAS B. (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;Axon;Calcium;Calcium Channel;Cell Adhesion Molecules;Cells;Chemical Synapse;Chemicals;Development;Diameter;Disease;Drosophila genus;EGF gene;Elements;Erinaceidae;fascinate;Fibroblast Growth Factor;Filopodia;Fingers;Glutamate Receptor;Glutamate Transporter;Glutamates;Goals;Grant;Imaging Device;intercellular communication;Learning;Mediating;Molecular;Movement;Names;Neuroglia;neuroglian;Neurons;notch protein;novel;Organ;Organelles;paracrine;Pattern;Play;postsynaptic;Process;programs;Property;Proteins;Research;response;Role;Signal Transduction;Signaling Protein;Source;Structure;Synapses;synaptotagmin;System;Thinness;Time;Tissues;vesicle-associated membrane protein;Viral Cancer;Virus Diseases;voltage;Work

PROJECT_TITLE: Molecular mechanisms in development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: College Station

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: This project is relevant to public health because identifying how protein synthesis affects cell division will expand our grasp of the control of cell proliferation. Such processes play a key part in many diseases. Hence, the study we propose is relevant to NIH's mission because it will develop basic knowledge for progress in the treatment of disease.

PI_NAMEs: POLYMENIS, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Affect;amino acid metabolism;Biochemical;Biological Models;Biological Process;Carbon;Cell Cycle;Cell division;cell growth;Cell Nucleus;Cell Proliferation;Cells;Coupling;Data;Diffuse;Disease;Enzymes;Equipment and supply inventories;experimental study;Fatty Acids;flexibility;Folic Acid;Genetic;Goals;grasp;Growth;Hand;instrument;Isotopes;Knowledge;Link;lipid biosynthesis;lipid metabolism;lipid transfer protein;Lipids;Longevity;Measurement;Measures;Messenger RNA;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Methylation;Mission;Mitosis;Mitotic;Molecular;Morphology;mutant;novel therapeutic intervention;Nuclear;nuclear division;Nutrient availability;Output;Pathway interactions;Periodicals;Phenotype;Phosphatidylinositol Transfer Protein;Phospholipids;Physiological;Play;Positioning Attribute;Process;Property;Protein Biosynthesis;Proteins;Proteome;Public Health;Purines;Research;Ribosomal Proteins;Ribosomes;RNA;RNA-Binding Proteins;Role;Saccharomycetales;Shapes;Testing;thymidylate;Transcript;Translating;Translation Process;Translational Derepression;Translations;United States National Institutes of Health;Yeasts

PROJECT_TITLE: Coupling of Protein Synthesis with Cell Division

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: Project Narrative Myocardial infarction (MI) often results in heart failure due to gradual loss of healthy cardiomyocytes and increased fibrosis. This proposal aims to determine how Pitx2 signaling protect cardiomyocytes after myocardial infarction and regulate the fibrotic signaling during myocardial remodeling. Improved understanding of Pitx2 signaling will provide alternative therapeutic strategies for treating MI.

PI_NAMEs: TAO, GE  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Affect;Alleles;Antioxidants;Binding;Biology;Cardiac;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;Cell Cycle;cell injury;Cell Nucleus;Cell Survival;Cells;Cessation of life;Cicatrix;Compensation;Complex;Cytoplasm;Data;Deposition;design;Down-Regulation;Electron Transport;Equilibrium;Extracellular Matrix;Feedback;Fibroblasts;Fibrosis;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Heart;Heart failure;Heart Injuries;homeodomain;Homeostasis;improved;In Vitro;Infarction;Injury;Left;Left ventricular structure;migration;Modeling;Modernization;mouse model;Mus;Myocardial;Myocardial Infarction;Myocardium;Myofibroblast;Natural regeneration;nuclear factor-erythroid 2;Nuclear Translocation;Operative Surgical Procedures;overexpression;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Primary Cell Cultures;programs;Proliferating;Proteins;Reactive Oxygen Species;regenerative;regenerative therapy;repaired;Reporting;Respiratory Chain;response to injury;Role;Signal Transduction;single cell sequencing;Testing;Therapeutic;Tissues;transcription factor;transcriptome;Transgenic Mice;ubiquitin-protein ligase;Ubiquitination;Ventricular;Ventricular Remodeling;Work

PROJECT_TITLE: The role of Pitx2 in heart injury and regeneration.

STUDY_SECTION: CCHF

STUDY_SECTION_NAME: Cardiac Contractility, Hypertrophy, and Failure Study Section[CCHF]


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Narrative The Columbia University Diabetes Research Center continues to facilitate interactions and collaborations among investigators from different academic backgrounds, providing material and intellectual support for initiatives that broaden our understanding of the causes of diabetes, and improve treatment outcomes; and to support the operation and improvement of technical facilities for research data acquisition and analysis, training opportunities for junior investigators and students, and seeding funds for potentially transformative pilot research projects.

PI_NAMEs: ACCILI, DOMENICO  (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Academic Medical Centers;Acceleration;Adult;Advocacy;Affect;Animals;Area;Atherosclerosis;Autoimmune;Award;Awareness;base;Basic Science;Behavioral;Beta Cell;Biological Markers;Biology;Biomedical Research;Cardiovascular system;Caring;Cell Physiology;Cell Separation;Childhood;Clinical;clinical care;clinical investigation;Clinical Investigator;clinical practice;Collaborations;collaborative approach;Communities;Complex;Core Facility;Cytometry;data acquisition;Data Analyses;Development;Diabetes Mellitus;Direct Costs;Discipline;Disease Management;Disease Pathway;Dyslipidemias;Education;effective therapy;Endocrinology;Environment;Epigenetic Process;Equipment;Equity;ethnic diversity;Ethnic Origin;experimental study;Facility Designs;Faculty;Failure;Financial Support;Fostering;Funding;Gender;Generations;Genetic;global health;Goals;Grant;Health;health disparity;Heart Diseases;Human Resources;human subject;Immunology;improved;Incentives;Individual;Inflammation;Infrastructure;innovation;Institution;Insulin;Insulin-Dependent Diabetes Mellitus;interest;International;Investigation;Investigator-Initiated Research;Islets of Langerhans;Laboratories;Leadership;Letters;lipid metabolism;member;Mentors;Mentorship;Metabolic;Metabolic syndrome;metropolitan;Mission;Molecular;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;Neurobiology;New York City;nutrition;Obesity;operation;Organ;outreach;pancreas development;pathology imaging;Persons;Phenotype;Physiological;Physiology;population health;Positioning Attribute;post-doctoral training;pre-doctoral;Predisposition;Productivity;programs;Protocols documentation;Replacement Therapy;Research;research facility;Research Personnel;Research Project Grants;Research Support;Resistance;Resources;Scientist;Services;Sister;socioeconomics;stem cells;Students;Therapeutic;Tissues;Training;training opportunity;Training Programs;Translating;Treatment outcome;type I and type II diabetes;U-Series Cooperative Agreements;Underrepresented Minority;Underserved Population;United States National Institutes of Health;Universities;Urban Population;urban underserved;Work

PROJECT_TITLE: Columbia Diabetes Research Center


NIH_SPENDING_CATS: Diabetes;Nutrition

PROJECT_TERMS: Acceleration;Advisory Committees;Animal Experimentation;Area;Atherosclerosis;Attention;Awareness;base;Biochemistry;Bioinformatics;Cardiology;Caring;Charge;clinical practice;Collaborations;college;Communication;Community Outreach;Core Facility;cost;Development;Developmental Biology;Diabetes Mellitus;Disparate;Electronics;Ensure;Environment;Equity;Event;Faculty;frontier;Funding;Genetic;Goals;Human Resources;human subject;improved;Individual;Information Dissemination;Institution;Instruction;interest;Interest Group;Joints;Laboratories;Leadership;Maintenance;meetings;member;Mentors;Mentorship;Metabolic;Metabolism;Mission;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;New York;novel therapeutics;nutrition;Obesity;Occupational activity of managing finances;operation;Physicians;post-doctoral training;pre-doctoral;Procedures;programs;Radioactive;Regulation;Reporting;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Schools;Scientist;Series;Sister;Students;Surgeon;symposium;Teacher Professional Development;Technology Transfer;Training;Training Programs;United States National Institutes of Health;Universities;Update;Veins;Vision;web site

PROJECT_TITLE: Administration Core


NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Physical Activity;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: NARRATIVE Good glycemic control is important for optimal health and prevention of acute and chronic complications among people living with diabetes, but food insecurity is a serious barrier to achieving good glycemic control, particularly among underrepresented racial/ethnic groups. This is the first longitudinal study that will characterize how food insecurity affects glycemic control measured by continuous glucose monitoring and the impact it has on health care utilization on a day-to-day basis in youth and young adults with type 1 and type 2 diabetes.

PI_NAMEs: LIESE, ANGELA D (contact);MENDOZA, JASON A

PROGRAM_OFFICER_NAME: ARTIS DICKERSON, SHAVON

PROJECT_TERMS: Accelerometer;Acute;Address;Affect;anxiety symptoms;Behavior;Caring;Categories;Chronic;Cluster Analysis;cohort;Cohort Studies;Continuous Glucose Monitor;coping;Data;Data Collection;depressive symptoms;design;diabetes management;Diabetes Mellitus;diabetes self-management;Diabetic Ketoacidosis;Diet;Ecological momentary assessment;Enrollment;Epidemiology;Equation;Ethnic Origin;Ethnic Population;Event;Exhibits;experience;Food;food insecurity;food security;Funding;Future;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care service utilization;Health system;Household;Individual;Inequity;innovation;Insulin-Dependent Diabetes Mellitus;Interruption;Intervention;Interview;Knowledge;Length;Life;Link;Lived experience;Longitudinal Studies;Measures;Mental Health;Methods;Modeling;Moods;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Outcome;outcome disparities;Participant;Patient-Focused Outcomes;Patients;Pattern;Persons;Physical activity;Play;Policies;Prevention;primary outcome;Process;Prospective Studies;Qualitative Methods;Race;racial population;Recording of previous events;Research;Role;Seasons;Secure;sedentary;Structure;Subgroup;Technology;Testing;Time;type I and type II diabetes;Underrepresented Populations;United States;Variant;Work;young adult;Youth

PROJECT_TITLE: Impact of Disparities in Food Security on Glycemic Control and Health CareUtilization Among Youth and Young Adults with Diabetes

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


PI_NAMEs: FERRANTE, ANTHONY W (contact)

PROJECT_TERMS: Adipose tissue;analysis pipeline;Animals;Award;base;behavioral phenotyping;Beta Cell;Body Composition;bone mass;Brain;Brain imaging;Closure by clamp;Complement;Complex;Complications of Diabetes Mellitus;Consultations;cost effective;Data;Development;Diabetes Mellitus;diabetes pathogenesis;Diabetic mouse;Disease;Energy Intake;Energy Metabolism;Equipment;equipment acquisition;Expenditure;experimental study;extracellular vesicles;Failure;Fatty acid glycerol esters;Feeding behaviors;Functional disorder;Funding;Gastrointestinal tract structure;Generations;Genetic;glucose disposal;glucose metabolism;glucose production;Grant;Histologic;human disease;Hyperglycemia;Image;Immunologics;Indirect Calorimetry;Individual;Infrastructure;Injections;insight;instrumentation;Insulin;insulin secretion;Joints;Laboratories;lipid metabolism;Lipids;Maintenance;Measurement;Measures;Mediation;member;Metabolic;Metabolic Diseases;metabolic phenotype;Methods;Mission;Modeling;Modernization;Molecular;Motor Activity;mouse model;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Operative Surgical Procedures;Organism;Pathology;Phenotype;Procedures;Process;Production;protein metabolism;Publications;Quality Control;Reproducibility;Research;Research Personnel;Resources;response;Rodent;Rodent Model;S10 grant;Scientist;Services;Surveys;System;Technical Expertise;Thinness;Tissues;tool;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Mouse Core


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative The overall mission of this proposal is to improve sepsis patient care by identifying and harnessing new mechanisms in the body’s own resolution phase of inflammation that can be used to control the excessive inflammatory responses that occur in sepsis. These include experiments focused on the specialized pro- resolving mediators (SPMs), their new autocoid pathways producing potent cys-SPM, and SPM mechanisms we’ve discovered to permit their use in human resolution physiology and pharmacology. The potential for resolution mechanisms as a new means to stratify sepsis and other maladies could diminish the consequences of prolonged uncontrolled infectious inflammation, organ damage and shorten recovery time.

PI_NAMEs: SERHAN, CHARLES NICHOLAS (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Address;Anabolism;Animal Model;Blood;CD59 Antigen;Chemicals;defense response;design;Disease;experimental study;Failure;Family;Financial Hardship;flexibility;Heart;Human;human tissue;improved;Infection;Inflammation;Inflammatory Response;innovation;Intervention;Knowledge;Laboratories;Life;Lipoxins;Lung;Macrophage;Maps;Mediator;Microbe;Mission;Molecular;Monitor;mortality;National Institute of General Medical Sciences;neuroprotection;neutrophil;Nosocomial Infections;novel;novel therapeutic intervention;Operative Surgical Procedures;Organ;Outcome;Pathway interactions;Patient Care;Pharmacology;Phase;Physiology;pre-clinical;programs;Public Health;Recovery;Recurrence;resilience;Resolution;response;Sepsis;septic patients;Shapes;Signal Transduction;Structure;Technology;Time;Trauma

PROJECT_TITLE: Evaluating Resolution Mechanisms for Infectious Inflammation


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

PHR: A cornerstone of several common therapies for human diseases is the use of a vein as a conduit to increase blood flow such as the arteriovenous fistula, the preferred access for hemodialysis. However, fistulae have extremely high rates of both early and late failure, and these poor clinical results lead to patient suffering and extensive expenditure of precious healthcare dollars and other resources for additional re-do procedures and surgery. The work to be accomplished within this proposal addresses the knowledge gap in the biology of venous remodeling that has created a serious unmet need for novel approaches to enhance venous adaptation to the fistula environment and enable successful long-term use of venous conduits in both women and men.

PI_NAMEs: DARDIK, ALAN  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: Address;Arteriovenous fistula;Biology;Blood flow;Blood Vessels;Cell Proliferation;Cells;Chronic Kidney Failure;Clinical;clinical translation;Clinical Trials;Collagen;Data;density;Deposition;End stage renal failure;Endothelial Cells;Environment;Expenditure;experience;Extracellular Matrix;Failure;Female;Fistula;Funding;Goals;Healthcare;Hemodialysis;hemodynamics;Human;human disease;Hyperplasia;Immune;Immunity;immunoregulation;improved;in vivo;in vivo Model;Inflammation;innovation;Intervention;Investigation;Knockout Mice;Knowledge;Legal patent;local drug delivery;Macrophage;male;Mechanics;Mediating;Mediator;men;Methodology;Modeling;mouse model;Mus;nanoparticle;Needles;Nephrectomy;next generation;novel;novel strategies;Operative Surgical Procedures;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Physiology;Procedures;Proteins;Puncture procedure;Resources;Sex Differences;shear stress;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Specimen;T-Lymphocyte Subsets;Techniques;Tenascin;Testing;tool;transcriptomics;Transforming Growth Factor beta;Veins;Venous;Wild Type Mouse;Woman;Work

PROJECT_TITLE: Manipulating the matrix to improve arteriovenous fistula patency

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The integration of evidence-based screening and suicide prevention delivered by community health workers into pediatric primary care has the potential to address mental health service gaps experienced by Latinx youth and their families, reduce suicidal ideation and behavior, and prevent youth suicide. Systems-level approaches to the identification and management of suicidal ideation and behavior developed in this study may be broadly generalizable to populations of underserved youth from families with limited English proficiency and in settings with limited mental health service workforce capacity.

PI_NAMEs: ALVAREZ, KIARA ;POLK, SARAH  (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: acceptability and feasibility;Address;Administrator;Adolescent;Adopted;Age;bilingualism;care coordination;Caring;Cause of Death;Certification;Characteristics;Child;Child Rearing;Childhood;Climate;Clinic;Collaborations;collaborative care;Communication;Communities;community clinic;Community Health;Community Health Aides;Community Practice;Consolidated Framework for Implementation Research;cost;Data;Death Rate;Development;Disparity;Early Intervention;Educational Materials;effectiveness evaluation;Effectiveness of Interventions;Eligibility Determination;evidence base;Evidence based intervention;experience;Family;Federally Qualified Health Center;Feeling suicidal;Female;Focus Groups;follow-up;Future;Goals;health care service;health care settings;Health Personnel;Health Professional;Health Promotion;Health Services;Hospitals;Human Resources;Immigrant;Immigrant family;implementation protocol;Implementation readiness;improved;Interruption;Intervention;Interview;Latina;Latino;Latinx;Limited English Proficiency;Linguistics;literacy;male;Maps;Medical;medical specialties;member;Mental Health;mental health education;Mental Health Services;Methods;Modeling;National Institute of Mental Health;Nature;Outcome;Parents;patient centered medical home;Patients;pediatrician;peer support;Pilot Projects;pilot trial;Population;practice setting;preference;prevent;Prevention;preventive intervention;Primary Care;primary care practice;primary care setting;Procedures;Process;programs;Protocols documentation;Provider;psychoeducation;Randomized, Controlled Trials;reducing suicide;Reporting;Resources;Role;Safety;screening;Self Efficacy;service delivery;service gap;Services;Site;social stigma;Spanish/English;Strategic Planning;Structure;suicidal behavior;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;suicide rate;Supervision;System;system-level barriers;Testing;Time Series Analysis;Training;Underserved Population;Visit;Well Child Visits;Work;Youth

PROJECT_TITLE: Improving screening and follow-up for suicidal ideation and behaviors among Latinx youth in primary care


NIH_SPENDING_CATS: Bioengineering;Diabetes;Nutrition

ORG_CITY: NEW YORK

PI_NAMEs: LAFERRERE, BLANDINE B (contact)

PROJECT_TERMS: Amino Acids;analytical method;Animal Model;Articulation;Attention;base;Bioinformatics;Biological;Biological Assay;Biological Markers;blood glucose regulation;C-Peptide;Catecholamines;Classification;Clinical;Clinical Investigator;clinical phenotype;Clinical Research;Collaborations;Consultations;Contracts;Core Facility;cost;Data;Data Analyses;Development;Diabetes Mellitus;Diet;Dietary Intervention;Disease;Dyslipidemias;energy balance;Enzyme-Linked Immunosorbent Assay;Experimental Designs;Fingerprint;Funding;Genetic;Glucagon;glucagon-like peptide 1;Glucose;glucose output;glucose tolerance;Glycerol;Grant;Hepatic;Homeostasis;Hormonal;Hormones;Human Resources;human subject;Hydrocortisone;improved;Individual;instrumentation;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Investigation;investigator training;Investments;Ketones;Kinetics;Laboratories;lipidomics;Lipids;Lipoproteins;Liquid substance;Maintenance;Mass Spectrum Analysis;Measurement;Medical;member;Metabolic;Metabolism;metabolomics;Methods;Molecular Genetics;Monitor;new technology;Nonesterified Fatty Acids;novel;operation;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Plasma;Postdoctoral Fellow;Publications;Radioimmunoassay;Regimen;Reproducibility;Research;Research Personnel;Resources;sample collection;Services;skills;small molecule;stable isotope;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Training;translational study;type I and type II diabetes;Universities

PROJECT_TITLE: Translational Biomarker Analytical Core


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE In this proposal, we seek to improve the outcome of patients with relapsed/refractory NHL who have failed CAR19 T-cell therapy. We identified CD70 as a novel therapeutic target after CAR19 T-cell failure. Here, we propose a Phase I/II clinical trial to test the safety and efficacy of CD70 targeting CAR-NK cells in this patient population. In addition, we propose to conduct IND enabling studies to develop the next-generation CD70 targeting CAR-NK cells by silencing the immune checkpoint CIS to enhance their potency and metabolic fitness. 1

PI_NAMEs: BASAR, RAFET ;DAHER, MAY  (contact);REZVANI, KATY

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Adoptive Transfer;aerobic glycolysis;Allogenic;Antigen Targeting;Antigens;Autologous;B lymphoid malignancy;B-Lymphocytes;biobank;c-myc Genes;Cancer Center;CASP9 gene;CD19 gene;CD70 antigen;Cell Therapy;Cells;cellular transduction;checkpoint inhibition;chimeric antigen receptor T cells;CISH gene;Classification;Clinic;Clinical;Clinical Protocols;Clinical Research;cost;cost effective treatment;Cryopreservation;cytokine;Data;design;Disease remission;Dose;Effector Cell;Endowment;engineered NK cell;Event;exhaustion;Exhibits;Failure;FDA approved;first-in-human;fitness;Gene Modified;Generations;Genes;genetically modified cells;Good Manufacturing Process;graft vs host disease;Human;human study;Immune;immune checkpoint;Immune Targeting;immunoengineering;improved outcome;In Vitro;in vivo;innovation;Institutional Review Boards;interest;Interleukin-15;knockout gene;Link;lymph nodes;Lymphoid Cell;lymphoid neoplasm;Lymphoma cell;Malignant lymphoid neoplasm;manufacture;manufacturing process;Mediating;metabolic fitness;Natural Killer Cells;neoplastic cell;new therapeutic target;next generation;NK cell therapy;novel;novel strategies;overexpression;patient population;Patient-Focused Outcomes;Patients;Pattern;peripheral blood;pharmacologic;Phase I/II Clinical Trial;point of care;Population;Preparation;pressure;prevent;Prognosis;Proliferating;Protein Deficiency;Proteins;Proteomics;Protocols documentation;Publishing;receptor;Refractory;Relapse;Research;Resistance;Retroviral Vector;Safety;safety testing;Sampling;senescence;Signal Transduction;Specificity;suicide gene;T cell therapy;T-Lymphocyte;Testing;Toxic effect;transcriptomics;Translations;tumor;Tumor Antigens;Umbilical Cord Blood;vector;Viral

PROJECT_TITLE: Next Generation Engineered NK Cells for Lymphoma Patients after CD19 CAR-T Cell Failure.

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND STATE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Young people transitioning from the foster care system are at elevated risk for a range of mental health diagnoses, but they are often less prepared to manage mental health challenges and more likely to have negative perspectives on help- seeking, increasing the risk of unmet needs as service use rapidly declines following the exit from foster care. We are pilot testing an indicated prevention intervention to improve coping self-efficacy and help-seeking attitudes in ways that lead to adaptive functioning, including social support-seeking and mental health treatment engagement. Our remotely- delivered group-based intervention approach is a broadly scalable enhancement to existing foster youth transition services, and is likely transferable to similar service-involved youth populations during the transition to adulthood.

PI_NAMEs: BLAKESLEE, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: Administrator;Adolescent;Age;aged;Anxiety;arm;Attitude;Behavior;behavioral health;biological adaptation to stress;care systems;Child Welfare;children of color;clinically relevant;Cognitive;cognitive change;cohort;coping;Coping Behavior;coping mechanism;Coping Skills;Country;Data;depressive symptoms;design;Diagnosis;Diagnostic;Educational Curriculum;Effectiveness;effectiveness trial;effectiveness/implementation trial;emotion regulation;Emotional;Ensure;evidence base;experience;feasibility research;Feedback;flexibility;follow-up;foster care;Fostering;Funding;Goals;group intervention;health service use;help-seeking behavior;implementation framework;improved;Independent Living;indicated prevention;Individual;Intervention;Investigational Therapies;Justice;Lesbian Gay Bisexual Transgender Queer;Measures;member;Mental Depression;Mental Health;Mental Health Services;Methods;Modeling;novel;Oregon;Outcome;peer;Persons;pilot test;Population;Populations at Risk;post intervention;Post-Traumatic Stress Disorders;Prevention program;preventive intervention;programs;Protocols documentation;psychosocial;Public Health;Randomized;recruit;remote delivery;remote grading;remote group;Research;Research Personnel;Residential Treatment;response;Risk;Rural;Secondary Prevention;Self Efficacy;service delivery;service engagement;service providers;Service setting;Services;services as usual;Signal Transduction;Site;skills;Social support;Standardization;Stress;Stress and Coping;Subgroup;support network;System;Testing;therapy development;Training;transition to adulthood;treatment group;treatment trial;uptake;young adult;Youth

PROJECT_TITLE: Pilot Testing an Intervention to Enhance Coping and Increase Mental Health Help-seeking Among Transition-Age Youth in Foster Care

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Pediatric

PHR: A commonality in childhood speech disorders, like autism spectrum disorders, primary apraxia, or stutter, is the inability to properly coordinate the movement of the ~100 muscles to speak. Here, our goal is to identify and characterize if a small collection of neurons is specialized to harmonize verbalizations with breathing. This work will provide a platform for future studies to understand the brain-wide systems that create vocalizations and how they are changed in various speech pathologies.

PI_NAMEs: YACKLE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Ablation;Address;Anatomy;Animals;Apraxia;Articulators;autism spectrum disorder;Behavior;Birds;Birth;Brain;Brain Mapping;Brain Stem;Breathing;central pattern generator;Characteristics;Childhood;Classification;Collection;Complex;Crying;Data;Dissection;Distant;Dysarthria;Elements;Enterobacteria phage P1 Cre recombinase;Fishes;FLP recombinase;Foundations;Future;Genetic Code;Goals;Human;In Vitro;individuals with autism spectrum disorder;Infant;Knowledge;Label;Laryngeal muscle structure;Larynx;Learning;Monitor;Monkeys;Motor;motor behavior;Motor Neurons;Movement;Mus;Muscle;Neonatal;neonatal mice;neural;neural circuit;Neurons;neuroregulation;novel;optogenetics;Pattern;Periodicity;Preparation;Production;programs;Reproducibility;respiratory;Respiratory Muscles;Sensory;Slice;Songbirds;sound;Speech;Speech Disorders;Speech Pathology;Stereotyping;Structure;Stuttering;System;Testing;theories;Time;Tongue;verbal;vocalization;Work

PROJECT_TITLE: Determination of the motor patterning system for murine vocalizations with breathing

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Diabetes;Genetics;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PI_NAMEs: CREUSOT, REMI J (contact)

PROJECT_TERMS: Address;Adipose tissue;Alpha Cell;animal tissue;antibody conjugate;Apoptosis;base;Beta Cell;Cancer Center;Cell Cycle;Cell Proliferation;Cell Separation;Cell surface;cell type;Cells;Center Core Grants;Chimeric Proteins;Collection;Complex;Core Facility;cost;CRISPR screen;cytokine;Cytometry;Dedications;design;Development;Diabetes Mellitus;disease model;Dyes;Eligibility Determination;Endocytosis;engineered stem cells;epigenetic profiling;Equipment;experience;experimental study;flexibility;Flow Cytometry;Flow Cytometry Shared Resource;fluorescence imaging;Fluorescence-Activated Cell Sorting;Frequencies;Gene Expression Profiling;Genes;genetic profiling;Grant;Hepatocyte;Herbert Irving Comprehensive Cancer Center;Housing;human tissue;humanized mouse;Immune;Immunologics;implantation;In Vitro;in vivo;Individual;Institution;instrument;instrumentation;Insulin-Dependent Diabetes Mellitus;Investments;Islet Cell;Lipids;Liver;Lymphoid Cell;Lymphoid Tissue;Lysosomes;Measurement;Measures;Medicine;member;Metabolic;migration;Mitochondria;Modeling;Molecular;Monitor;mouse model;mRNA Expression;Neurons;new technology;Organelles;Organoids;Oxidative Stress;Pancreas;Pathway interactions;Phenotype;Physiological;Ploidies;Population;Procedures;programs;Proliferating;protein protein interaction;protein purification;Quality Control;Reagent;Receptor Signaling;release of sequestered calcium ion into cytoplasm;Reproducibility;Research;Research Personnel;Resolution;Role;S10 grant;Sampling;Services;Signal Transduction;stem cells;T-Cell Activation;Techniques;Technology;Therapeutic;Tissues;tool;transcription factor;translational immunology;United States National Institutes of Health;Universities

PROJECT_TITLE: Cytometry Core