NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Clonal expansion of blood cells carrying acquired mutations in DNMT3A is common in older adults and associated with an increased risk of developing hematological malignancies and cardiovascular disease. Molecular mechanisms underlying these associations are poorly understood. The objective of this project is to examine the impact of DNMT3A mutations on the inflammatory response of human myeloid cells, with the ultimate goal of identifying novel therapeutic approaches for the prevention and treatment of inflammatory diseases associated with DNMT3A mutations.

PI_NAMEs: BYUN, MINJI  (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: Address;Affect;Age;aged;aging population;Animal Model;Base Pairing;Binding;biobank;Biological Assay;Blood Cells;Cardiovascular Diseases;Cell Differentiation process;Cell Lineage;Cell model;cell type;Cells;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Clonal Expansion;cohort;Computerized Medical Record;Coronary heart disease;Coupled;cytokine;Data;Defect;design;Development;Diagnosis;Disease;disease model;DNA;DNA Methylation;DNMT3a;DNMT3a mutation;drug use screening;Enrollment;Enzymes;epigenetic drug;Epigenetic Process;ethnic diversity;Functional disorder;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic;genetic manipulation;Genetic Transcription;genome editing;genome-wide;genomic locus;Genotype;Goals;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Heterozygote;Human;human embryonic stem cell;human pluripotent stem cell;IL6 gene;Immunology;Individual;induced pluripotent stem cell;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-6;Knowledge;Link;Macrophage;Malignant Neoplasms;Mediating;Modeling;Molecular;Molecular Profiling;monocyte;Mus;Mutate;Mutation;Mutation Analysis;mutation carrier;Myeloid Cells;Myelopoiesis;neutrophil;novel;novel strategies;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;null mutation;older adult;Orthologous Gene;Output;Pathologic;Patients;Phenotype;Population Heterogeneity;Positioning Attribute;Predisposition;prevent;Prevention approach;promoter;Proteins;Proteomics;Public Health;recruit;Repressor Proteins;Research Personnel;Risk;Role;single-cell RNA sequencing;Source;stem cell biology;stem cell model;Study models;System;Techniques;Technology;transcription factor;transcriptome sequencing;transcriptomics;United States

PROJECT_TITLE: Altered inflammatory response associated with acquired DNMT3A mutations

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Our goal is to determine how higher-order thalamus interacts with different populations of GABAergic interneurons to mediate inhibition in the mouse prefrontal cortex (PFC). Using a combination of electrophysiology, optogenetics and 2-photon microscopy, we will examine how two thalamic inputs interact with a variety of interneurons, how these cells synapse onto other excitatory and inhibitory cells, and how a subset of interneurons contacts the dendrites to inhibit local Ca2+ signaling. Our experiments will help elucidate how the thalamus interacts with the PFC to support cognitive function and how this may go awry in mental health disorders.

PI_NAMEs: CARTER, ADAM G (contact)

PROGRAM_OFFICER_NAME: NADLER, LAURIE SUE

PROJECT_TERMS: Animals;Apical;Area;Attention deficit hyperactivity disorder;Behavior;Cell Nucleus;cell type;Cells;Cognitive;cognitive function;Complex;Data;Dendrites;Distal;Electrophysiology (science);experimental study;Functional disorder;Goals;Image;insight;Interneurons;Mediating;Mental disorders;Mus;neuronal cell body;neuropsychiatric disorder;novel;optogenetics;Photons;Physiology;Play;Population;Prefrontal Cortex;Primates;Property;Pyramidal Cells;Rodent;Role;Schizophrenia;sensory cortex;sensory system;Shapes;Signal Transduction;Synapses;Testing;Thalamic Nuclei;Thalamic structure;therapeutic target;Transgenic Mice;two photon microscopy;two-photon;Whole-Cell Recordings;Work

PROJECT_TITLE: Synaptic and dendritic physiology in the prefrontal cortex


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project Narrative Of the 12 million children in the USA growing up bilingual, about 1 million experience Developmental Language Disorder (DLD), a disorder in language learning and use. Currently there is no guidance for speech language pathologists (SLPs) as to the language of intervention for bilingual children with DLD with differing degrees of proficiency with English or Spanish. This project will examine the relationship between relative language proficiency and the language of intervention, considering monolingual intervention in English and Spanish and bilingual intervention presented by alternating English and Spanish treatment sessions with the goal of improving language outcomes and thereby strengthening long-term academic achievement.

PI_NAMEs: CASTILLA-EARLS, ANNY P. (contact);VAN HORNE, AMANDA JEAN OWEN

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: Academic achievement;Academic skills;Address;Age;autism spectrum disorder;bilingualism;Censuses;Child;Child Language;Clinical;Complex;Crossover Design;Data;Development;Disease;Education;elementary school;Enrollment;experience;girls;Goals;Grant;hearing impairment;Home;improved;individualized medicine;Inequity;innovation;Intellectual functioning disability;Intervention;Knowledge;Language;Language Development;Language Development Disorders;language outcome;Lead;Learning;Learning Difficulty;Linguistics;Love;Measures;Outcome;Outcome Assessment;Outcome Measure;Pathologist;Positioning Attribute;Production;programs;Randomized, Controlled Trials;Recommendation;Research;Role;Service provision;Services;skills;Spanish;Spanish/English;Speech;Sterile coverings;Structure;success;syntax;Testing;Time;treatment effect;treatment response;Work

PROJECT_TITLE: The relationship between child language proficiency and language of treatment on the outcomes of bilingual children with developmental language disorder


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Heart Disease;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Prevention;Sleep Research;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE The prevalence of post-traumatic stress disorder (PTSD) is growing at an alarming rate in the U.S, and these patients are at significantly greater risk for developing hypertension and cardiovascular disease. Women are twice as likely as men to develop PTSD, a chronic stress disorder that may negate the cardiovascular protection conferred by female hormones before menopause. This study of the neural and vascular consequences of PTSD in premenopausal women will help inform the development of therapies to improve cardiovascular health in this growing and high-risk population of women.

PI_NAMEs: FONKOUE, IDA TCHUISSEU (contact)

PROGRAM_OFFICER_NAME: NEILSON, KAREN MARY

PROJECT_TERMS: actigraphy;Address;Adult;arterial stiffness;arterial tonometry;aspirate;Behavior;Biological Availability;blood pressure elevation;Blood Vessels;brachial artery;cardioprotection;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career development;Chronic stress;Clinical Research;Clinical Sciences;comparison control;Data;design;Development;Diagnosis;didactic education;Disease;Doppler Ultrasound;Early Intervention;Endothelium;Environment;Estradiol;Estrogens;experience;Female;Funding;Future;Generalized Anxiety Disorder;Goals;Grant;Growth;Health;high risk;high risk population;High Risk Woman;Hormonal;Hormones;Hour;Human;Hypertension;Impairment;improved;improvement on sleep;Inosine Dialdehyde;Intervention;Kidney;Knowledge;Lead;Leg;Link;Master of Science;Measures;Mediating;men;Menopause;Menstrual cycle;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Movement;multidisciplinary;Muscle;Nerve;neural;Neuronal Dysfunction;Nightmare;Nitric Oxide;Outcome;Panic Disorder;Pathway interactions;Patients;Periodicals;Peripheral;Physiological;Physiology;Plasma;Play;poor sleep;Post-Traumatic Stress Disorders;Premenopause;Prevalence;Prevention strategy;Production;programs;protective effect;Psyche structure;renal artery;Research;Research Personnel;Research Project Grants;Resources;Rest;Risk;Role;Severities;skills;Sleep;Sleep Apnea Syndromes;Sleep disturbances;Sleeplessness;Stress;stress disorder;Surveys;Sympathetic Nervous System;Testing;therapy development;tonometry;Training;Translational Research;Trauma;trauma exposure;Trauma Research;United States National Institutes of Health;Universities;vascular abnormality;Vascular Diseases;vasoconstriction;Vulnerable Populations;Woman;Women's Health;Work;young woman

PROJECT_TITLE: Autonomic and Vascular Mechanisms of Cardiovascular Risk in Women with Post-traumatic Stress Disorder (PTSD)


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE This project aims to understand both how complex neuronal tissues differentiate during human development and how genetic variation can affect this process by studying two highly medically relevant, in vitro, temporally dynamic differentiation systems that faithfully recapitulate fetal differentiation patterns of the brain. For each of these differentiation systems, we will carry out aims that span efforts toward mapping, perturbing, modeling, validating, and learning from single cell derived molecular data sets, with a goal of learning DNA sequence elements that drive gene expression programs during developmental timepoints. This understanding will provide mechanistic insight into how DNA sequence elements cooperate to bring about cell state and fate changes and help identify the genetic determinants of diseases of the brain.

PI_NAMEs: GREENLEAF, WILLIAM JAMES (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: 3-Dimensional;Ablation;Affect;ATAC-seq;autism spectrum disorder;Automobile Driving;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Models;Brain;Brain Diseases;brain tissue;Cell model;cell type;Cells;Cerebral cortex;ChIP-seq;Chromatin;Cognition;Collaborations;combinatorial;Complex;Computer Models;Cortical Cord;CRISPR interference;CRISPR/Cas technology;Data;Data Set;de novo mutation;deep learning;Development;developmental disease;Developmental Process;Disadvantaged;Disease;DNA Sequence;DNA-Directed RNA Polymerase;Elements;Enhancers;fetal;Foundations;Gene Expression;gene regulatory network;Genes;Genetic;Genetic Determinism;Genetic Transcription;genetic variant;Genetic Variation;Genome;genomic data;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Human;Human Development;human induced pluripotent stem cells;human model;In Vitro;Individual;insight;Intellectual functioning disability;Joints;knock-down;Learning;Link;Maps;Measures;Medical;method development;Methods;Modality;Modeling;Molecular;multiple input multiple output;multiple omics;Mutation;network models;neural model;neural network;Neural Network Simulation;neurodevelopment;Neurons;neuropsychiatry;Nucleic Acid Regulatory Sequences;Nucleotides;Organ;Organoids;Output;Patients;Pattern;Phenotype;Polymerase;predictive modeling;Process;Productivity;programs;Proliferating;Property;Proteins;Recording of previous events;Regulation;Regulatory Element;Research Personnel;RNA;single cell analysis;Specific qualifier value;spheroids;Spinal Cord;syntax;System;Testing;Time;Tissue Differentiation;Training;training data;Trans-Activators;transcription factor;Transcription Factor 3;transcriptome sequencing;Untranslated RNA;Validation;Variant;Work;XCL1 gene

PROJECT_TITLE: Defining and perturbing gene regulatory dynamics in the developing human brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Narrative T cell receptor recognition of peptide-MHC epitopes is the nexus of adaptive immune recognition. “Decoding” this interface has the potential to drive innovation in diagnostics and therapeutics, but is currently limited by the lack of sufficient data for modeling and new computational approaches incorporating sequence, structure, and transcriptional data. We propose an integrated program of experimental, statistical, and structural biological expertise to define the TCR:pMHC interface.

PI_NAMEs: THOMAS, PAUL G. (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 3-Dimensional;Address;Antigens;Award;Binding;Biological;Cells;cohort;Collaborations;Collection;combinatorial;Complex;complex data;computer framework;Data;Data Set;Databases;Diagnostic;Epitopes;experimental study;Gene Expression;Genetic Transcription;Goals;Human;Immune;Immunologist;improved;Individual;Infection;innovation;Libraries;Major Histocompatibility Complex;Methods;Modeling;Nature;novel;novel strategies;pathogen;Pathologic;Peptide Receptor;Peptide/MHC Complex;Peptides;Peripheral Blood Mononuclear Cell;prediction algorithm;predictive modeling;Productivity;programs;protein protein interaction;Proteins;Protocols documentation;receptor;Recording of previous events;Reporting;Sampling;Source;Specificity;Structure;T Chain;T-Cell Antigen Receptor Specificity;T-Cell Receptor;TCR Activation;Therapeutic;tool;Training;Work

PROJECT_TITLE: DECODING THE INTERACTIONS BETWEEN T CELL RECEPTORS AND PEPTIDE-MHC

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(90)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: RELEVANCE TO PUBLIC HEALTH Ultrasound beamforming, the process of transforming ultrasound into an image, is based on the principles of wave propagation which are complex due to the soft tissue structure in the human anatomy. Currently, ultrasound imaging uses simplified models of wave propagation. Here we address these limitations with physically and anatomically realistic propagation models based on the human anatomy that can effectively train and harness the power of machine learning beamformers. This technique directly addresses the principal challenge and objective of ultrasound beamforming, which is to limit unwanted acoustical effects from superficial tissue while maximizing signal from deep targets. The advancement of the proposed technology addresses the clear clinical need to provide diagnostic imaging to the growing population of body-limited imaging cases.

PI_NAMEs: PINTON, GIANMARCO  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Abdomen;Acoustics;Address;Affect;Anatomic Models;Anatomy;Back;Calibration;Cardiac;Carotid Arteries;Cephalic;Characteristics;Clinical;Complex;Connective Tissue;Cryoultramicrotomy;Custom;Data;Data Set;Databases;deep learning;Dependence;design;Diagnosis;Diagnostic Imaging;Discipline of obstetrics;Effectiveness;Equipment;Fatty acid glycerol esters;Health;health care quality;Healthcare;high body mass index;Human;Human body;human data;human study;Image;image reconstruction;imaging modality;imaging system;improved;in vivo;in vivo imaging;Individual;large datasets;Learning;Left;Link;Liver;liver imaging;Machine Learning;Maps;Measurement;Medical Imaging;Methodology;Methods;Modeling;Modernization;neural;neural network;Noise;obese patients;Obesity;Overweight;Patients;Phase;Photography;Physics;Population;Process;Property;prototype;Public Health;radio frequency;Resolution;Signal Transduction;simulation;soft tissue;sound;Source;Structure;Surface;Techniques;Technology;Texture;Time;tissue phantom;Tissues;tool;Training;training data;Transducers;Translating;transmission process;Ultrasonic wave;Ultrasonography;ultrasound;United States;Weight

PROJECT_TITLE: A machine learning ultrasound beamformer based on realistic wave physics for high body mass index imaging

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Depression;Mental Health;Neurosciences

ORG_CITY: LAWRENCE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: PROJECT NARRATIVE The loss of an intimate relationship is a tragic fact in life that impacts 8 million individuals in the US annually. While there are well-defined and characterized animal models for understanding many neuropsychiatric conditions in humans, there are currently no laboratory animal models of social or relationship loss to evaluate the underlying neurocircuitry and develop targeted therapeutics for the most disruptive psychiatric disorder following loss, i.e., prolonged grief disorder. This proposal constitutes a significant advancement in developing a neurocircuit of social loss in an animal model, targeting the neuromodulation of corticostriatal brain regions by the mesolimbic DA system.

PI_NAMEs: SMITH, ADAM STEVEN (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Anatomy;Animal Model;Animals;Anterior;Anxiety;awake;Behavior;Behavioral;Behavioral Symptoms;Brain;Brain region;Breeding;calcium indicator;Cells;Cessation of life;Chemicals;cingulate cortex;Corpus striatum structure;Coupled;Cues;diagnostic criteria;Disease;Distress;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;dopaminergic neuron;DRD1 gene;DRD2 gene;Emotional;Evaluation;experience;Female;Fiber;G-Protein-Coupled Receptors;Genetic Markers;Goals;Grief reaction;Housing;Human;Implant;in vivo;Individual;innovation;insight;Label;Laboratory Animal Models;Lesion;Life;Limbic System;Literature;loved ones;male;Medical;Mental Depression;Mental disorders;mesolimbic system;Microtus;Modeling;Molecular Abnormality;Morbidity - disease rate;Motivation;mRNA Expression;nerve supply;neural;neural circuit;neurobiological mechanism;Neurobiology;neurochemistry;neurogenetics;neuroimaging;neuromechanism;Neurons;neuropsychiatry;neuroregulation;neurotransmission;new therapeutic target;Nucleus Accumbens;Odors;optical fiber;optogenetics;Outcome;Oxidopamine;Pain;Pair Bond;Partner in relationship;Pathway interactions;peer;Periodicity;pharmacologic;Pharmacology;Phenotype;Photometry;postsynaptic;prairie vole;preference;presynaptic;receptor;receptor binding;Research;resilience;response;Rewards;Rodent;Same-sex;Scanning;sensor;Signal Transduction;social;Social Behavior;Social isolation;social separation;Stress;Substance abuse problem;symptom cluster;Synapses;targeted treatment;Testing;Therapeutic Intervention;therapeutic target;Time;tool;transmission process;Ventral Tegmental Area;Vulnerable Populations;yearning

PROJECT_TITLE: Neurocircuit of Partner-seeking Following Social Loss

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-P(90)S]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Cardiovascular;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  Despite public awareness that tobacco smoke is harmful, many people still assume that marijuana smoke is benign. Moreover, cardiovascular effects of secondhand smoke exposure have remained relatively un- explored in human studies. The impact of the proposed project is that an improved understanding of the adverse cardiovascular effects of intentional or involuntary exposure to cannabis will better inform personal health behavior, advice of physicians to their patients, public health policy decisions, legal doctrines, and potential regulation of the cannabis industry and its products.

PI_NAMEs: SPRINGER, MATTHEW LAWRENCE (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: Acute;Address;Adverse effects;Age;Awareness;Benign;Biochemical;Biological Markers;Blood;Blood Pressure;Blood Vessels;Cannabinoids;Cannabis;Cannabis policy;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Cells;Chemicals;Chronic;circulating biomarkers;Clinical;Clinical Research;Electrocardiogram;Endothelial Cells;endothelial dysfunction;Endothelium;environmental tobacco smoke;environmental tobacco smoke exposure;exposed human population;Exposure to;Fibrosis;Functional disorder;Functional impairment;Goals;Health;Health behavior;Health Policy;Heart failure;Human;Impairment;improved;Incubated;Individual;Industry;Inflammation;Lead;Legal;Marijuana;marijuana legalization;marijuana smoke;Marijuana Smoking;marijuana use;Measures;Mediating;Medicine;Myocardial Infarction;Observational Study;Oxidative Stress;Patients;Permeability;Persons;Pharmaceutical Preparations;Physicians;Physiologic pulse;Plants;Platelet aggregation;Poison;Public Health;Rattus;Recreation;recruit;response;Risk;secondhand cannabis smoke;Smoke;Smoking;Testing;Time;Tissues;Tobacco;tobacco exposure;Tobacco smoke;tobacco smokers;Tube;vascular endothelial dysfunction

PROJECT_TITLE: Effects of chronic marijuana use on endothelial function

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: Chicago

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Title: C-terminal Peptide of Cardiac Troponin I for the Treatment of Diastolic Heart Failure Program Narrative  Troponin I (TnI) regulates cardiac muscle relaxation and is a therapeutic target in diastolic heart failure that is a clinical condition lacking effective treatment. The C-terminal 27 amino acid peptide isolated from cardiac TnI forms a functional reagent that selectively enhances diastolic function of cardiac muscle. Our research project investigates this myofilament-based mechanism for translational development toward a targeted treatment of diastolic heart failure.

PI_NAMEs: JIN, JIAN-PING  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Actomyosin Adenosinetriphosphatase;Adrenergic Agents;Adult;Aging;Amino Acids;Animals;Binding;Binding Sites;Biochemical;C-terminal;Calcium-Sensing Receptors;Cardiac;Cardiac Muscle Contraction;Cardiac Myocytes;Cardiac Output;Cardiovascular system;Chemicals;Chronic;Clinical;Clinical Treatment;Complex;Congestive Heart Failure;Cyclic AMP-Dependent Protein Kinases;Data;data modeling;desensitization;Development;Diastolic heart failure;dimer;Disease;effective therapy;EFRAC;Embryonic Heart;Failure;Functional disorder;Future;Genes;Genetic;Goals;Hearing;Heart;Heart failure;heart function;hemodynamics;Homing;Human;Impairment;improved;in vivo;in vivo evaluation;innovation;Kinetics;Length;Mediating;Medical;Methodology;Microfilaments;Modeling;Molecular Conformation;molecular modeling;Molecular Structure;Morbidity - disease rate;mortality;mouse model;Mus;Muscle;Muscle function;Muscle relaxation phase;Mutation;Myocardial;Myocardial dysfunction;Myocardium;Myofibrils;Myosin ATPase;N-terminal;novel;novel therapeutics;peptide drug;Peptides;Pharmaceutical Preparations;Phosphorylation;Physiological;Physiology;Play;preservation;programs;Protein Isoforms;protein structure function;Protein Subunits;Pump;Reagent;reconstitution;Regulation;Relaxation;Research;Research Project Grants;response;Rest;Role;Sarcomeres;side effect;Site;Skeletal Muscle;Skin;Stress;Stroke Volume;Structure;Structure-Activity Relationship;Sturnus vulgaris;targeted treatment;Therapeutic;Therapeutic Effect;therapeutic target;Thin Filament;Thinness;transgene expression;Transgenic Mice;Translating;translational potential;Treatment Efficacy;Tropomyosin;Troponin;Troponin C;Troponin I;Troponin T;Ventricular Remodeling;Vertebrates

PROJECT_TITLE: C-terminal Peptide of Cardiac Troponin I for the Treatment of Diastolic Hear Failure

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Human Genome;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Pulmonary Fibrosis;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Accurate diagnosis of the subtype of interstitial lung disease (ILD) is critical for guiding both prognosis and therapy for patients. However, ILDs with usual interstitial pneumonia (UIP) patterns on imaging can be difficult to discern due to their similar symptoms, pulmonary function tests, and radiographic findings. This proposal will leverage the power of peripheral blood single-cell RNA-sequencing to determine immune cell aberrations that may drive specific ILDs with UIP patterns to advance diagnoses and therapeutics for these patients.

PI_NAMEs: ZHAO, AMY YUE-TING (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: accurate diagnosis;Affect;antigen detection;Antigen Receptors;Antigens;Autoimmune;B cell repertoire;B-Cell Antigen Receptor;B-Lymphocytes;Biological Assay;Biological Markers;Biopsy;Blood;Blood Cells;Blood specimen;career;Categories;cell type;Cells;Chronic;Clinical;clinical diagnostics;Clinical Treatment;cohort;comparison control;complementarity-determining region 3;Connective Tissue;Connective Tissue Diseases;Data;Data Science;Decision Modeling;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;Disease Progression;disorder subtype;Etiology;experience;Extrinsic allergic alveolitis;Fellowship;Fibrosis;fibrotic interstitial lung disease;fibrotic lung;Foundations;Gene Expression;Gene Expression Profile;Goals;Guidelines;Health;idiopathic pulmonary fibrosis;Image;Immune;Immune response;Immunophenotyping;Immunosuppressive Agents;insight;Interstitial Lung Diseases;Learning;Lung;Lung Diseases;Methods;minimally invasive;Modality;mortality;Multiomic Data;Newly Diagnosed;novel;Patients;Pattern;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Physicians;Physiological;Precipitins;prevent;Process;Prognosis;Pulmonary function tests;Pulmonary Pathology;radiological imaging;receptor;Recommendation;Research;Risk;Sampling;Scientist;Scleroderma;Serum;Severity of illness;single-cell RNA sequencing;Structure of parenchyma of lung;Symptoms;T-Cell Receptor;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Training;United States;Usual Interstitial Pneumonia;Work

PROJECT_TITLE: Identifying Disease-Specific Immune Cell Shifts in Chronic Fibrotic Interstitial Lung Diseases with Single-Cell RNA Sequencing


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome;Rare Diseases;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOLOGY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Mitochondrial dysfunction is a leading cause of metabolic disease, affecting 1 in ~5000 individuals and this high incidence of disease is likely due to the complex genomic basis of mitochondrial function, which requires coordinated expression of 37 genes in the mitochondrial genome (mtDNA) and more than 1000 genes in the nuclear genome. This project will dissect the joint contribution of mtDNA- and nuclear-encoded genes to gene expression variation in Drosophila and determine how environmental factors can modify these responses. These experiments will provide information about the genetic basis of mitochondrial function for pathways related to environmental stressors, and may contribute to our understanding of the genetics of mitochondrial replacement therapy and the development of pharmaceuticals that compensate for reduced mitochondrial function.

PI_NAMEs: RAND, DAVID M (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Address;Adult;Affect;Age;base;Biological Assay;Biology;Child;Compensation;Complex;Complex Genetic Trait;Development;differential expression;Disease;Drosophila genus;Ensure;Environment;Environmental Risk Factor;environmental stressor;Epigenetic Process;experimental study;Female;fitness;Foundations;Gene Expression;gene expression variation;Gene Mutation;Genes;Genetic;genetic approach;Genetic Drift;Genetic Epistasis;Genetic Screening;Genetic Variation;Genome;Genomics;Genotype;Incidence;Individual;Joints;male;Medical Genetics;Metabolic Diseases;Mitochondria;Mitochondrial Diseases;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Modeling;Mothers;Mutation;Nuclear;Pathway interactions;Performance;Pharmacologic Substance;Phenotype;Physical environment;Population;Quantitative Genetics;Replacement Therapy;Research;response;sex;Signal Pathway;Source;trait;women's prevention

PROJECT_TITLE: Mitonuclear genetics of complex traits in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE With the rapid progress in oncology, there is a great need to train academic surgical oncologists who can not only deliver state-of-the art surgical care, but can also lead multidisciplinary teams as well as research programs leveraging molecular oncology and new technologies. The goal of this T32 training program is to train surgical trainees in the essential research skills necessary to be productive independent surgical investigators and leaders in surgical oncology. Our program is now entering its 35th year, and is now a sought-after program with a deep record of producing future leaders in surgical oncology.

PI_NAMEs: HOLDER, ASHLEY M;WARGO, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Surgical Oncologist;Training

PROJECT_TITLE: Training of Academic Surgical Oncologists

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The outlined project is relevant to public health because it seeks to develop novel treatment strategies for suffering from spinal cord injuries by determining the mechanisms underlying inflammatory macrophage retention, which prevents full resolution of the injury. Consequently, this research is relevant to the NIH’s goal of acquiring knowledge that can be used to treat human disabilities.

PI_NAMEs: REN, YI  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acceleration;Acute;Adhesions;Adhesives;Affect;Apoptotic;Area;autocrine;axon growth;Bone Marrow;Cells;Chemotactic Factors;Chronic;Chronic Phase;Collagen;Data;Demyelinating Diseases;density;Deposition;disability;Emigrations;Endothelial Cells;Extracellular Matrix;Fibronectins;Generations;Goals;healing;Human;Immune;improved;In Situ;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;injured;Injury;innovation;Investigation;Knowledge acquisition;Lesion;Lipids;Macrophage;Mediating;migration;Myelin;Necrosis;Nerve Regeneration;nerve stem cell;neural;neural growth;neuroinflammation;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Outcome;Pathway interactions;Phagocytes;Phase;Phenotype;prevent;Process;Public Health;Publications;Recovery of Function;Regulation;remyelination;Reporting;Research;Resolution;Signal Transduction;Site;Spinal;Spinal cord injury;Spinal Cord Lesions;Spinal Injuries;Tail;Testing;Therapeutic;Therapeutic Intervention;tissue regeneration;Tissues;treatment strategy;United States National Institutes of Health;uptake;Vascular Endothelial Cell;vascular inflammation;Work

PROJECT_TITLE: Exploring the therapeutic mechanisms of proinflammatory myelin-laden macrophages retention in the injured spinal lesion core

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Emerging Infectious Diseases;HIV/AIDS;Health Services;Infectious Diseases;Lung;Orphan Drug;Patient Safety;Primary Health Care;Rare Diseases;Tuberculosis

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Tuberculosis (TB) is a leading infectious disease killer among people with and without HIV in South Africa where antibiotic resistant forms of the infection are a significant public health concern. Newer treatment regimens for antibiotic resistant TB are shorter, better tolerated and have greatly improved treatment outcomes, yet access to these regimens is limited to physician-led, hospital-based programs. The BringBPaL2Me Trial will test whether it is safe and effective to offer such treatment in a primary care clinic using a nurse-led treatment model, as such, this trial has the potential to improve access to care and significantly reduce patient and health system costs.

PI_NAMEs: EVANS, DENISE ;FARLEY, JASON EDWARD (contact);NDJEKA, NORBERT ODIMBOLEKO

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: Adherence;Adjuvant Analgesic;Ambulatory Care;Antibiotic Resistance;arm;Blinded;Caring;chronic care model;Clinical;Clinical Trials Data Monitoring Committees;co-infection;Collaborations;Communicable Diseases;cost;cost-effectiveness evaluation;Decentralization;design;Diagnosis;District Hospitals;Dose;Early treatment;Education;effectiveness evaluation;Enrollment;Event;experience;fluoroquinolone resistance;follow-up;Guidelines;Health;Health Services Accessibility;Health system;HIV;HIV/TB;Home;Hospitals;Household;Improve Access;improved;Income;Infection;Linezolid;Managed Care;Medication Management;Modeling;Moxifloxacin;Mycobacterium tuberculosis;Nurses;Oral;Outcome;outpatient programs;Outpatients;Participant;patient oriented;Patients;Persons;Pharmaceutical Preparations;Physicians;Predisposition;Primary Care;primary care clinic;Principal Investigator;programs;provider adherence;Province;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;Regimen;Reporting;Research;Resistance;Resolution;Review Committee;Rifampicin resistance;Safety;Serious Adverse Event;Site;South Africa;South African;standard of care;Standardization;success;Symptoms;Testing;Time;treatment center;treatment guidelines;Treatment outcome;Treatment Protocols;trial comparing;Tuberculosis;tuberculosis treatment;Viral;World Health Organization

PROJECT_TITLE: The Bring BPaL2Me Trial - Comparing Nurse-Led RR-TB Treatment in Primary Care to Physician-Led, Hospital-Based RR-TB Treatment: A Cluster Randomized, Non-Inferiority Trial

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_DEPT: PATHOLOGY

PHR: NARRATIVE – OVERALL COMPONENT The CDC estimates that 3 million people are living with hepatitis C virus (HCV) infection in the United States and there is an annual infection rate of 34,000 new infections. This pU19 proposal focus on the development of a vaccine that will elicit broadly protective antibodies and cellular responses that are long-lasting. We expect that at the end of this program project, we will have a candidate vaccine to begin pre-clinical studies that will progress to Phase I/II clinical trial.

PI_NAMEs: FOUNG, STEVEN  (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Acute;adaptive immune response;Address;Adjuvant;Agonist;aluminum sulfate;Amino Acids;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Biopsy;Blood;Bone Marrow;CD8-Positive T-Lymphocytes;CD81 gene;Complex;cost;Data;Databases;design;Development;Disease Progression;draining lymph node;Engineering;Epitope Mapping;Epitopes;Exposure to;fitness;flexibility;Frequencies;Genetic Recombination;Genotype;Glycoproteins;Goals;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Home;Immune response;Immunity;Immunization;immunogenic;immunogenicity;Immunologic Memory;improved;Individual;Infection;infection rate;Innate Immune Response;Kinetics;Lead;Lipid A;Liposomes;Liver;Macaca;Masks;Modeling;Modification;Molecular Conformation;molecular modeling;Monitor;mosaic;Mus;Mutate;Mutation;neutralizing antibody;nonhuman primate;novel;Pan Genus;Patients;Persons;Phase;Phase I/II Clinical Trial;Polysaccharides;preclinical study;prevent;Probability;programs;Property;QS21;receptor;receptor binding;Recombinants;Resolution;response;Risk;Sampling;Saponins;Series;stem;Structure;Surface;synergism;System;T cell response;T memory cell;T-Lymphocyte;tissue resident memory T cell;TLR4 gene;United States;Vaccinated;Vaccination;vaccination strategy;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;vaccine response;Vaccines;Viral;viral genomics;Viral Vector;Virion;Virus;Work

PROJECT_TITLE: A vaccine design to induce protective B and T cell immunity against hepatitis C virus


NIH_SPENDING_CATS: Cost Effectiveness Research;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Vaccine Related

PROJECT_TERMS: Advisory Committees;authority;Award;B-Lymphocytes;Budgets;Collaborations;Communication;Conflict (Psychology);Conflict of Interest;cost effectiveness;Data;Decision Making;Ensure;Evaluation;Expenditure;Future;General Population;Goals;Grant;Guidelines;Hepatitis C virus;Human Resources;Immunity;Institution;Lead;Leadership;Logistics;Manuscripts;meetings;member;Monitor;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Office of Administrative Management;Preparation;Prevention;Process;Productivity;programs;Progress Reports;Publications;Records;Regulation;Reporting;Research;Research Project Grants;Resolution;Resources;Series;Services;Site;symposium;System;T-Lymphocyte;Travel;United States National Institutes of Health;Universities;Vaccine Design

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PI_NAMEs: VILLINGER, FRANCOIS J (contact)

PROJECT_TERMS: Adjuvant;Animal Model;Anti-viral Agents;Anti-viral Response;Antigens;antiviral drug development;arm;Attenuated;B-Lymphocytes;Biopsy;Blast Cell;Blood;Bone Marrow;cell mediated immune response;Cells;Collaborations;Consumption;cost effective;Cytotoxic T-Lymphocytes;Data;Defense Mechanisms;Development;Distant;draining lymph node;Effectiveness;Engineering;Epidemic;Epitopes;Experimental Designs;fitness;Flavivirus;Generations;Genetic Variation;Genome;Genomics;Genotype;Germ Lines;Goals;Hepatitis;Hepatitis C;Hepatitis C virus;HIV;Human;Immune;immune function;Immune response;Immune system;Immunity;Immunization;improved;Infection;Interferons;intrahepatic;Link;Liver;Macaca;Macaca mulatta;Malignant Neoplasms;Mediating;Modeling;Monitor;mosaic;mutant;Mutation;neutralizing antibody;nonhuman primate;Nonstructural Protein;novel strategies;novel vaccines;opioid epidemic;Pan Genus;Paralysed;Pathology;Patients;Persons;Plasma;Plasma Cells;Polymerase;Polysaccharides;Predisposition;prevent;Preventive vaccine;Process;programs;Proteins;Recombinant Proteins;recruit;Regulatory T-Lymphocyte;Resolution;response;Rodent;Role;sample collection;Sampling;scaffold;Series;Structure;superinfection;T-Lymphocyte;Testing;Therapeutic;Time;Vaccine Design;Vaccines;Viral;Viral Vector;Virus;ward

PROJECT_TITLE: Vaccine against HCV in nonhuman primates


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PROJECT_TERMS: Achievement;Address;Adjuvant;Affinity;Alberta province;Animal Experiments;Antibodies;Antibody Response;Antibody titer measurement;Antigens;B-Lymphocytes;Back;Benchmarking;Binding;Bone Marrow;Cavia;chronic infection;Collaborations;Databases;design;Elements;Epitope Mapping;Epitopes;flexibility;Foundations;Genotype;Glycoengineering;glycosylation;Goals;Hepatitis C Vaccine;Hepatitis C virus;Human;human monoclonal antibodies;Immune;Immune Sera;Immunity;immunogenic;immunogenicity;Immunologics;improved;in vivo;Liver;Maps;Measures;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;mouse model;Mus;mutant;neutralizing antibody;Pan Genus;Plasma Cells;Plasmablast;polyclonal antibody;Polysaccharides;Predisposition;preservation;prevent;Process;Production;Property;Protein Engineering;Proteins;rational design;Recombinants;Resistance;Resolution;response;Series;Structure;Study models;synergism;T cell response;T-Lymphocyte;Testing;Transmembrane Domain;Vaccinated;Vaccine Design;vaccine development;Vaccines;Viral;Virus;Work

PROJECT_TITLE: Structure-guided vaccine design of HCV E1E2 to induce broadly neutralizing antibodies (bNAbs)


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PI_NAMEs: WALKER, CHRISTOPHER M. (contact)

PROJECT_TERMS: Acute;adaptive immune response;Adjuvant;Alleles;Amino Acids;Animals;Antibodies;Antigens;Archives;B-Cell Development;B-Lymphocytes;Biomedical Research;Bone Marrow;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Chimeric Proteins;chronic infection;Collecting Cell;Computer Analysis;cross reactivity;Cryopreservation;design;Development;Ethnic Origin;Failure;Family;Frequencies;Genes;Genetic Variation;Genotype;Geographic Locations;Goals;Haplotypes;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Human;Immune;Immune response;Immunity;improved;Infection;Innate Immune Response;Link;Liver;Macaca mulatta;Measurement;Measures;Mediating;MHC Class I Genes;Modeling;Mononuclear;mosaic;neutralizing antibody;Nonstructural Protein;Outcome;Pan Genus;Pathway interactions;Pattern;Phenotype;Polyvalent Vaccine;Population;prevent;Productivity;programs;Proteins;Resolution;response;Sampling;Site;Structure;synergism;T cell response;T memory cell;T-Lymphocyte;tissue resident memory T cell;Tissues;transcriptome;Transgenes;Transgenic Mice;Translating;United States National Institutes of Health;Vaccinated;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;Vaccines;vector;Viral Vector;Virus

PROJECT_TITLE: Strategies to enhance vaccine-primed T cell immunity against HCV


PI_NAMEs: PULENDRAN, BALI  (contact)

PROJECT_TERMS: adaptive immune response;Adjuvant;Affinity;Agonist;aluminum sulfate;Anti-viral Response;Antibodies;Antibody Response;Antibody titer measurement;Antigens;B-Lymphocytes;biological systems;Blood;Bone Marrow;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Collaborations;design;Environment;Epitopes;Evaluation;Gene Expression Profiling;Genes;Genotype;Glycoproteins;Goals;Hepatitis C Vaccine;Hepatitis C virus;Hepatocyte;Home;Human;Immune response;Immunity;Immunization;Immunize;immunogenicity;Infection;Innate Immune Response;Learning;Ligands;Lipid A;Liposomes;Liver;Molecular;Monoclonal Antibodies;mosaic;Mucous Membrane;Mus;Myeloid Cells;neutralizing antibody;nonhuman primate;novel;Phase I Clinical Trials;Plasma Cells;QS21;response;Saponins;scaffold;Shapes;Somatic Mutation;Specificity;synergism;T cell response;T-Lymphocyte;Testing;tissue resident memory T cell;TLR4 gene;TLR7 gene;Vaccination;vaccination strategy;Vaccine Design;vaccine development;Vaccines;Variant;Viral;Viral Vaccines;Viral Vector;Work

PROJECT_TITLE: Immunogenicity to B and T cell vaccines in non-human primates (NHPs)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Prevention;Vaccine Related

PI_NAMEs: KUHN, RICHARD J. (contact)

PROJECT_TERMS: Animals;Antibodies;Antigens;Architecture;B-Lymphocytes;Binding;Bioinformatics;Biology;Biophysics;Cavia;CD81 gene;Complex;Computer Models;Cryo-electron tomography;Cryoelectron Microscopy;Crystallography;Data;design;Electron Microscopy Facility;Engineering;Epitopes;experience;Flavivirus;Genotype;Glycoproteins;glycosylation;Goals;Hepatitis C;Hepatitis C Vaccine;Hepatitis C virus;Human;human pathogen;Immunity;Immunology procedure;in vivo evaluation;insight;Laboratories;lead candidate;Length;Mediating;Membrane Glycoproteins;Methods;Modification;Molecular Conformation;molecular modeling;Molecular Virology;Mutation;nanodisk;Nature;neutralizing antibody;nonhuman primate;novel;Outcome;particle;plasmid DNA;Polysaccharides;Preparation;Production;programs;Proteins;Protocols documentation;receptor;receptor binding;Recombinant Proteins;Recombinants;Research;Resolution;response;Role;structural biology;Structure;Surface;Synchrotrons;T-Lymphocyte;Testing;tool;Transmembrane Domain;Vaccine Design;Vaccines;Viral;Viral Pathogenesis;Virion;Virus;Virus Receptors;Work;X-Ray Crystallography

PROJECT_TITLE: Structural analysis of HCV E1E2 glycoproteins


PHR: NARRATIVE – Overall Component We will use a systems biological approach to address two fundamental questions in vaccinology: (i) What are the mechanisms by which novel COVID-19 vaccines stimulate immune responses? (ii) What is the impact of the microbiome on immunity to vaccination? The highly collaborative projects and cores of the Stanford-HIPC will address these issues leading to new and potentially actionable insight about human immunity to vaccines.

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Ablation;adaptive immunity;Address;Adjuvant;Adult;Algorithms;Allergic Disease;Allergic Reaction;Antibiotics;antigen-specific T cells;Antigens;Automobile Driving;Award;B-Lymphocytes;Bioinformatics;Biological Assay;Biological Markers;biological systems;Cells;Clinical;Clinical Trials;Computer Models;COVID-19 vaccine;cytokine;Cytometry;Data Analyses;data integration;data management;Data Security;Data Storage and Retrieval;data submission;Databases;Development;Ensure;epigenomics;Exposure to;Human;human subject;Immune;Immune response;Immunity;Immunologic Monitoring;Immunologic Stimulation;Immunology;immunoregulation;Individual;Influenza;influenza virus vaccine;insight;Messenger RNA;metabolomics;microbiome;microbiota;Molecular Profiling;multiple omics;National Institute of Allergy and Infectious Disease;Natural Immunity;Nature;new technology;novel;Pfizer-BioNTech COVID-19 vaccine;Plasma;Population;Predisposition;public database;Rabies Vaccines;Recombinants;Recommendation;recruit;Reporting;Research Personnel;Research Project Grants;response;RNA vaccine;Role;Sampling;Saponins;seasonal influenza;Services;single cell analysis;South Africa;South African;Special Population;Standardization;System;T cell response;T-cell receptor repertoire;Technology;transcriptomics;Vaccination;vaccine development;vaccine immunogenicity;Vaccines;vaccinology;Validation;Work

PROJECT_TITLE: Systems biological assessment of innate and adaptive immunity to vaccination


NIH_SPENDING_CATS: Immunization;Prevention;Vaccine Related

PROJECT_TERMS: adaptive immunity;biological systems;Clinical;Collaborations;Communication;Conflict of Interest;design;Ensure;Goals;Guidelines;Infrastructure;Institution;Lead;Leadership;meetings;member;Monitor;Natural Immunity;Occupational activity of managing finances;Office of Administrative Management;Productivity;programs;Progress Reports;Reporting;Research;Research Project Grants;Resources;Services;United States National Institutes of Health;Universities;Vaccination


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: NADEAU, KARI C. (contact)

PROJECT_TERMS: Ablation;adaptive immunity;Address;Adherence;Adjuvant;Adult;Africa;Algorithms;Allergic Disease;Allergic Reaction;Antibiotics;antigen-specific T cells;Antigens;Automobile Driving;Award;B-Lymphocytes;Bioinformatics;Biological Assay;Biological Markers;biological systems;Blood;Bone Marrow Aspiration;Cataloging;Cells;Clinical;Clinical Immunology;Clinical Investigator;Clinical Research;clinical training;Clinical Trials;Collaborations;Communication;Computer Models;COVID-19 vaccine;cytokine;Cytometry;Data;Data Analyses;data integration;data management;Data Security;Data Storage and Retrieval;data submission;Databases;Development;Ensure;epigenomics;expectation;Exposure to;Fine needle aspiration biopsy;Goals;Good Clinical Practice;Guidelines;Hospitals;Human;Human Resources;human subject;human subject protection;Immune;Immune response;Immunity;Immunologic Monitoring;Immunology;immunoregulation;improved;Individual;Influenza;influenza virus vaccine;Informatics;Infrastructure;Institutional Review Boards;Longitudinal Studies;Measures;Messenger RNA;metabolomics;microbiome;microbiota;Molecular Profiling;Monitor;multiple omics;National Institute of Allergy and Infectious Disease;Natural Immunity;Nature;new technology;novel;Performance;Pfizer-BioNTech COVID-19 vaccine;Plasma;Population;Practice Guidelines;Predisposition;Procedures;Process;Protocols documentation;public database;Quality Control;Rabies Vaccines;Recombinants;Recommendation;recruit;Reporting;Research;Research Personnel;Research Project Grants;response;RNA vaccine;Role;sample collection;Sampling;Saponins;Scientific Advances and Accomplishments;search engine;seasonal influenza;Services;single cell analysis;South African;Special Population;Specimen;Standardization;System;T cell response;T-cell receptor repertoire;Technology;Training;transcriptomics;Translational Research;United States National Institutes of Health;Update;Vaccination;vaccine development;vaccine immunogenicity;Vaccines;vaccinology;Validation;Work

PROJECT_TITLE: Clinical Core


PI_NAMEs: MAECKER, HOLDEN T. (contact)

PROJECT_TERMS: adaptive immunity;antibody test;Antigens;Biological Assay;biological systems;Cells;Clinical;Clinical Research;Collaborations;comparative;cytokine;Data;Data Analyses;data exchange;data integration;data management;Data Set;Databases;demographics;Deposition;DNA Methylation;Equipment;Foundations;Genomics;Goals;Grant;Human;Human Resources;Immune;Immunoassay;Immunologic Monitoring;Immunology;Immunology procedure;Immunophenotyping;improved;Inflammation;Infrastructure;Journals;Laboratories;Maps;Natural Immunity;Paper;Peripheral Blood Mononuclear Cell;Phenotype;Principal Investigator;Proteins;Publications;Recording of previous events;Research Personnel;Resources;Sampling;SARS-CoV-2 antibody;Science;Seminal;Serum;Services;Stains;Standardization;success;System;Technology;transcriptomics;usability;Vaccination;Viral Antibodies;Virus

PROJECT_TITLE: Human Immune Monitoring Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Microbiome;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: Ablation;adaptive immune response;adaptive immunity;Address;Adjuvant;Adult;Allergic Reaction;Anti-viral resistance;Antibiotics;Antibody Response;antigen-specific T cells;B-Lymphocytes;biological systems;Cells;Clinical Trials;COVID-19 vaccination;COVID-19 vaccine;cytokine;Cytometry;Dendritic Cells;Dengue;Development;Epigenetic Process;epigenomics;Exposure to;Fine needle aspiration biopsy;Frequencies;gut microbiota;Human;Hypersensitivity;Immune response;Immunity;immunogenicity;Immunologics;Immunology;immunoregulation;Impairment;imprint;Individual;Influenza;Influenza A Virus, H5N1 Subtype;influenza virus vaccine;innate immune mechanisms;Innate Immune Response;insight;lymph nodes;Memory;Messenger RNA;metabolomics;microbiome;microbiota;Molecular Profiling;monocyte;multiple omics;Myelogenous;Myeloid Cells;Natural Immunity;Nature;Novavax COVID-19 vaccine;novel;pandemic influenza;Peripheral Blood Mononuclear Cell;Pfizer-BioNTech COVID-19 vaccine;Plasma;Population;Predisposition;Rabies Vaccines;Rabies virus;Recombinants;Reporting;Resistance;response;RNA vaccine;Role;Sampling;Saponins;seasonal influenza;Secondary Immunization;Serum;South Africa;South African;Special Population;System;transcriptomics;Vaccinated;Vaccination;vaccine development;vaccine immunogenicity;Vaccines;vaccinology;Viral;Virus;Work;young adult;ZIKA

PROJECT_TITLE: Systems biological assessment of innate responses to vaccination


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: LEXINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The cell wall of Streptococcus mutans, the primary etiological agent of human dental caries, is composed of peptidoglycan decorated with serotype-specific glycopolymers. The proposed research investigates the structure, biosynthesis and function of the serotype c- specific glycopolymer. The outcomes of this research are expected to have a positive impact on the development of highly targeted therapeutics to control S. mutans infections.

PI_NAMEs: KOROTKOVA, NATALIA  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Adherence;Affect;Anabolism;Analytical Chemistry;anti-microbial drug;Antibiotics;antimicrobial;Antimicrobial Resistance;Autolysin;Autolysis;Bacteremia;Biochemical;Biogenesis;Biology;carbohydrate biosynthesis;carbohydrate structure;Carbohydrates;Cell division;cell envelope;Cell Physiology;Cell surface;Cell Wall;Cellular Morphology;Charge;Chemical Structure;Classification;Collaborations;Defect;Dental caries;Development;Divalent Cations;Drug Design;drug development;Drug Targeting;Enzymatic Biochemistry;Enzymes;Etiology;extracellular;Future;Genetic;Glucose;Glycerol;Goals;Gram-Positive Bacteria;Human;improved;In Vitro;Infection;Infective endocarditis;inorganic phosphate;insight;Knowledge;Light;Link;lipoteichoic acid;Mass Spectrum Analysis;Mechanics;Methods;Microbial Biofilms;Microscopy;Modeling;Modification;Molecular;Molecular Genetics;Molecular Structure;Morphology;mutant;nanomechanics;neutrophil;NMR Spectroscopy;novel;novel strategies;Oral cavity;Outcome;Outcomes Research;pathogen;Pathogenesis;Pathway interactions;Peptidoglycan;Permeability;Phenotype;Phospholipase A2;Phospholipids;Play;Polysaccharides;Predisposition;Preparation;Process;Property;Proteins;Publishing;quorum sensing;Rattus;recruit;Regulation;Reporting;Research;Resistance;Rhamnose;Role;Septal Region;Serotyping;Signal Transduction;Spatial Distribution;Streptococcus;Streptococcus mutans;Streptococcus pyogenes;Structure;Surface;targeted treatment;Techniques;Testing;therapeutic target;therapeutically effective;Transferase;Vertebral column;Virulence;Work

PROJECT_TITLE: Biosynthesis, structure and function of cell wall in Streptococcus mutans

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Brain Disorders;Mental Health;Neurosciences;Sleep Research

PHR: While sleep and wake dynamics are critical to animals' survival and are intertwined with psychiatric diseases, how sleep- and wake-promoting signals are integrated from the brainstem to the cerebral cortex remain unclear. In this proposal, we focus on the role of astrocytes—the most abundant non-neuronal cell type in the brain—in sensing and responding to histaminergic neuromodulatory signals, and determining the sleep/wake state of the cortex. Our results will illuminate mechanisms by which astrocytes coordinate the activity of populations of neurons across brain states.

PI_NAMEs: DAVIS, GRAEME W (contact);PAZ, JEANNE T

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Acetylcholine;Address;Animal Behavior;Animals;Area;Astrocytes;Basic Science;Biological;Brain;Brain Stem;Calcium;cell type;Cells;Cerebral cortex;Dopamine;Electrophysiology (science);Equilibrium;Exhibits;extracellular;Fiber;Future;Glutamates;Goals;Health;Histamine;Histamine H1 Receptors;Histamine Receptor;Human;Image;in vivo;Knowledge;mammilloinfundibular nucleus structure;Maps;Measures;Mental disorders;Metabolic Diseases;Modeling;Modernization;Molecular;Morphology;Nervous System Disorder;neural;neural circuit;Neurobiology;Neuroglia;Neuromodulator;neuronal circuitry;Neurons;neuroregulation;neurotransmission;Norepinephrine;Optics;Outcome;Output;Physiological;Physiology;Population;Potassium;Process;Receptor Activation;receptor expression;Receptor Signaling;Regulation;Research;response;Role;Signal Transduction;Sleep;sleep regulation;spatiotemporal;System;targeted treatment;Techniques;Technology;Testing;tool;two-photon;Work

PROJECT_TITLE: Non-Neuronal Sleep/Wake Control in Cortex

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: DAVIS, MARK MORRIS (contact)

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adjuvant;Adult;Algorithms;Alleles;Allergic Reaction;Antibiotics;Antibody Binding Sites;antigen-specific T cells;B-Lymphocytes;biological systems;Blood;Cells;Clinical Trials;cohort;combinatorial;complementarity-determining region 3;COVID-19;COVID-19 vaccination;COVID-19 vaccine;Defect;draining lymph node;Epitopes;Exposure to;falls;Ferritin;Frequencies;Goals;Grouping;gut microbiota;Human;Hypersensitivity;Immune;Immunologics;Individual;influenza virus vaccine;Label;Lymphocyte;Messenger RNA;Methods;microbiome;microbiota;Natural Immunity;novel;Organoids;Peptide/MHC Complex;Peptides;Pfizer-BioNTech COVID-19 vaccine;Phenotype;phenotypic biomarker;Probability;Rabies Vaccines;Reporting;response;RNA vaccination;RNA vaccine;Sampling;SARS-CoV-2 spike protein;seasonal influenza;Sequence Analysis;Specificity;Stains;Subunit Vaccines;success;Surveys;T cell response;T-cell receptor repertoire;T-Lymphocyte;Techniques;Technology;tool;Universities;Vaccination;vaccine response;Vaccines;Vertebral column;young adult

PROJECT_TITLE: Systems biological assessment of T cell responses to vaccination


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Social Determinants of Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The proposed work implicates trauma-induced disruptions in key brain regions controlling proactive coping behavior. If successful, these studies will provide a roadmap for continuing research into the neurobiological underpinnings of resilience and susceptibility, and lay the groundwork for novel, evidence-based behavioral and pharmacological therapy strategies.

PI_NAMEs: SEARS, ROBERT MILTON (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Adrenergic beta-Antagonists;Adult;Amygdaloid structure;Animal Behavior;Animals;antagonist;Anxiety;Anxiety Disorders;Avoidance Learning;Behavior;Behavior Control;Behavioral;beta-adrenergic receptor;Brain;Brain region;Brain Stem;Cells;Clinical;comparison control;conditioned fear;Conflict (Psychology);coping;Coping Behavior;Coping Skills;CRISPR/Cas technology;Data;early life stress;Early-life trauma;Electrophysiology (science);Emotional;Equilibrium;evidence base;Evidence based treatment;Exhibits;Exposure to;fear memory;Freezing;Fright;Functional disorder;Future;Goals;Heart;Human;improved;in vivo;Individual;Infusion procedures;Intervention;Lateral;Learning;locus ceruleus structure;Measures;Mediating;Mental disorders;Methodology;Microdialysis;Molecular;neural circuit;Neurobiology;Neurons;Neurotransmitters;Norepinephrine;Norepinephrine Receptors;norepinephrine system;novel;optogenetics;Panic;Patients;Perception;Performance;Pharmaceutical Preparations;pharmacologic;Phenotype;Photometry;Population;Predisposition;prevent;Propranolol;Psychopathology;Publishing;Rattus;Reaction;receptor;Research;resilience;response;Role;Shock;Signal Transduction;single-cell RNA sequencing;Somatostatin;Source;Stimulus;Techniques;Testing;Training;Trauma;treatment strategy;Whole-Cell Recordings;Work

PROJECT_TITLE: Brainstem Modulation of Proactive Coping

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Relevance: In this project, we seek to improve the predictive accuracy of a computerized histomorphometric predictor (OHbIC) for risk stratification, outcome prediction and added benefit of adjuvant chemotherapy for patients with oral cavity squamous cell carcinoma (OC-SCC) from routine H&E tissue slide images. The success of this project will pave the way for its adoption as a tissue non-destructive Affordable Precision Medicine (APM) companion diagnostic tool, allowing for the identification of OC-SCC patients for whom therapies could be either left as standard, or require “escalation”, depending on the OHbIC risk score.

PI_NAMEs: LEWIS, JAMES ;MADABHUSHI, ANANT  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Adjuvant;Adjuvant Chemotherapy;Adjuvant Therapy;Adoption;Adult;advanced disease;Age;American Cancer Society;American Joint Committee on Cancer;Architecture;behavioral outcome;Biological Assay;Cancer Center;Categories;Cells;Cessation of life;chemoradiation;chemotherapy;Classification;Clinic;Clinical;Clinical stratification;Clinical Trials;Clinical Trials Cooperative Group;Cloud Computing;cohort;Collaborations;collaborative trial;companion diagnostics;Computer Assisted;Computer Vision Systems;computerized;cost;density;Diagnosis;diagnostic tool;digital;digital imaging;Disease;Eligibility Determination;European Organization for Research and Treatment of Cancer;Excision;Foundations;Head and neck structure;Hematoxylin and Eosin Staining Method;high risk;high risk population;Histologic;Image;improved;India;innovation;Institution;Invaded;Left;lymphatic Invasion;malignant mouth neoplasm;Malignant Neoplasms;Measurement;Measures;men;Modeling;Molecular;Morphology;mouth squamous cell carcinoma;neoplastic cell;Nuclear;Operative Surgical Procedures;Oral cavity;Outcome;outcome prediction;patient prognosis;Patient risk;Patient Selection;patient stratification;Patient-Focused Outcomes;Patients;Pattern;Pattern Recognition;perineural;Platinum;Postoperative Period;precision medicine;predict clinical outcome;predictive marker;predictive test;prognostic;prognostic assays;Prognostic Marker;prognostic of survival;prognostication;progression risk;prospective;Radiation;Radiation therapy;Radiation Therapy Oncology Group;Recurrence;Regimen;Relapse;Resources;Risk;Risk Marker;risk stratification;San Francisco;Shapes;Slide;Smoking;Staging;Stains;Standardization;success;Surgical Oncology;Surgical Pathology;System;Systemic Therapy;targeted treatment;Testing;Texture;Therapeutic;Tissue Microarray;Tissue Stains;Tissues;tool;Training;treatment choice;tumor;tumor behavior;Tumor Cell Invasion;Tumor stage;Tumor-Infiltrating Lymphocytes;United States;United States National Institutes of Health;Universities;Validation;Visual;Woman;Work

PROJECT_TITLE: Oral Cavity Quantitative Histomorphometric Risk Classifier (OHbIC) in Oral Cavity Squamous Cell Carcinoma (OC-SCC)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

PI_NAMEs: BOYD, SCOTT DEXTER (contact)

PROJECT_TERMS: 2019-nCoV;Ablation;Acute;adaptive immunity;Adjuvant;Adverse reactions;Affect;Affinity;Allergic;Antibiotic Therapy;Antibiotics;Antibodies;Antibody Response;Antibody titer measurement;Antigens;Avidity;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Basophils;Binding;Biological Assay;biological systems;Blood;Bone Marrow;Cells;Clinical;clinically significant;Clone Cells;Collaborations;combat;COVID-19;COVID-19 pandemic;COVID-19 vaccine;Data Analyses;data management;Development;DNA;Ensure;Epitopes;Fine needle aspiration biopsy;Food Hypersensitivity;Future;Glycoproteins;Human;Humoral Immunities;Immunity;Immunoglobulin G;Immunoglobulin M;Immunology;in vitro Assay;Individual;Infection;Investigation;Label;Longevity;lymph nodes;Measures;Memory B-Lymphocyte;Methods;microbiome;microbiota;Monitor;Monoclonal Antibodies;monoclonal antibody production;mRNA lipid nano particle vaccine;multiplex assay;Natural Immunity;novel;novel coronavirus;Participant;pathogen;Pathogenicity;Pathway interactions;peripheral blood;Phenotype;Plasma Cells;Plasmablast;Polyethylene Glycols;Population;Rabies;Rabies Vaccines;Reaction;Recombinant Proteins;Recording of previous events;recruit;Reporting;response;RNA vaccination;RNA vaccine;Role;Sampling;SARS coronavirus;SARS-CoV-2 antigen;Serology;Shapes;Specificity;Specimen;Structure of germinal center of lymph node;T-Lymphocyte;transcriptome sequencing;Vaccination;vaccination strategy;vaccine development;vaccine immunogenicity;vaccine platform;vaccine response;Vaccinee;Vaccines;vaccinology;Variant;variants of concern;Viral;Virus;Virus Diseases

PROJECT_TITLE: Systems biological assessment of B cell responses to vaccination


ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative A Cereblon Signaling Network in Wnt-driven Cancers In the United States, colorectal cancer is the second leading cause of cancer-related death. The goal of this study is to determine how a network of signaling proteins results in the initiation and growth of colorectal cancers, to discover what happens to colorectal cancer cells when proteins from this network are blocked, and to identify new strategies to inhibit the growth of colorectal cancer cells based on these discoveries. Therefore, the knowledge gained from this study may provide new ways to treat colorectal cancer.

PI_NAMEs: AHMED, YASMATH  (contact);LEE, ETHAN ;ROBBINS, DAVID J

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Animals;anti-cancer;Apoptosis;arm;Attenuated;beta catenin;Binding;Binding Proteins;Biochemical;Biological Markers;Bypass;cancer cell;Cancer Etiology;Cancer Model;casein kinase;Cause of Death;cell behavior;cell growth;Cell Line;Cell Maintenance;Cells;Cessation of life;Characteristics;Clinical;Clinical Trials;clinically relevant;Colon;Colorectal Cancer;colorectal cancer progression;Complex;Cultured Cells;Data;Data Set;Development;Disease;Drosophila genus;drug development;Drug Targeting;druggable target;Engineering;FDA approved;Genetic Engineering;Goals;Growth;Hematologic Neoplasms;Human;Human Engineering;Implant;In Vitro;in vivo;inhibitor;innovation;Intestines;Knowledge;loss of function;Malignant Neoplasms;Measures;member;Modeling;Molecular;multidisciplinary;Mus;Mutation;neoplastic cell;novel;novel therapeutic intervention;Organoids;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;Play;Post-Translational Protein Processing;Proliferating;Proteins;Publishing;receptor;reconstitution;recruit;Regulation;Role;Signal Transduction;Signal Transduction Pathway;Signaling Protein;small molecule;stem cells;Testing;translational potential;treatment strategy;tumor growth;tumor progression;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;United States;WNT Signaling Pathway;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: A Cereblon signaling network in Wnt-driven cancers

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Immunization;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related

PI_NAMEs: KHATRI, PURVESHKUMAR  (contact)

PROJECT_TERMS: adaptive immune response;adaptive immunity;Address;Adjuvant;Area;ATAC-seq;B-Lymphocytes;Bioinformatics;bioinformatics tool;Biological;biological systems;biomedical data science;Cells;Clinical;cohort;Cohort Analysis;Collaborations;complex data;Computational Biology;computational suite;computer framework;computer science;computerized tools;COVID-19 vaccine;cytokine;Data;Data Analyses;data de-identification;data integration;data management;Data Security;Data Set;data sharing;Data Storage and Retrieval;data submission;Databases;Development;differential expression;Doctor of Philosophy;experience;Funding;Gene Expression;Gene Expression Profile;Generations;Genetic Transcription;Goals;Health Insurance Portability and Accountability Act;Heterogeneity;Human;human data;Immune;Immune response;Immune system;Immunity;Immunologist;Immunology;improved;Individual;Infection;Innate Immune Response;Knowledge;Link;Masks;Measures;Mediating;Medicine;member;Messenger RNA;metabolic profile;metabolomics;Methods;microbiome;mid-career faculty;Modeling;Molecular Profiling;multimodality;Multiomic Data;multiple omics;National Institute of Allergy and Infectious Disease;Natural Immunity;neutralizing antibody;novel;Pathway interactions;Peripheral Blood Mononuclear Cell;Plasma;Population;public repository;Recording of previous events;repository;Research;response;Role;Sampling;Scientist;Serum;Services;single-cell RNA sequencing;Statistical Data Interpretation;System;T cell response;T-Lymphocyte;Techniques;Testing;tool;Transcript;transcription factor;transcriptome;United States National Institutes of Health;Universities;Vaccination;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;Virus Diseases

PROJECT_TITLE: Data Management and Analysis Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infant Mortality;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: PROJECT NARRATIVE Significant disparities in maternal and infant mortality and morbidity exist in the U.S. Novel strategies, including new therapies and technologies, innovative study designs and interventions, inclusion of diverse study participants into clinical trials, and input from the stakeholders impacted by health disparities are needed to improve outcomes for pregnant and lactating people. Although California accounts for nearly one eighth of annual U.S. births, the MFMU Network lacks a West Coast site. The University of California, San Francisco (UCSF) is a pioneer in innovative research techniques and has a racially and ethnically diverse patient population, so could contribute important perspectives to the MFMU Network goals to improve pregnancy outcomes.

PI_NAMEs: NORTON, MARY E (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Area;Attention;Basic Science;Birth;Black race;California;Caring;climate change;climate impact;Clinic;Clinical;clinical care;Clinical Research;Clinical Services;Clinical Trials;Collection;community partnership;Comprehensive Health Care;Conscious;COVID-19 impact;COVID-19 pandemic;COVID-19 vaccine;Diabetes Mellitus;Disparity;DNA;Education;Endocrinology;Enrollment;Ensure;Environment;Environmental Impact;Environmental Pollutants;Epigenetic Process;Equity;ethnic diversity;Ethnic Origin;Ethnic Population;experience;fetal;Fetal Growth;Gender Identity;General Hospitals;Genetic;Genomics;Goals;health disparity;health equity promotion;Health system;Heart Diseases;high risk;Hospitals;Hypertension;implementation science;improved;improved outcome;in utero;Individual;Infant;infant morbidity/mortality;Infection;Infrastructure;innovation;Intervention;Lactation;marginalized community;Maternal complication;Maternal Mortality;Maternal-fetal medicine;Maternal-Fetal Medicine Units Network;medical specialties;metagenomic sequencing;Metagenomics;Methodology;microbial;Mission;Molecular;Multi-Institutional Clinical Trial;Multicenter Trials;multidisciplinary;neonatal morbidity;Neurology;new technology;novel;novel strategies;novel therapeutics;obstetric care;obstetrical complication;opioid epidemic;Outcome;Outpatients;Participant;patient oriented;patient population;Patients;Perinatal;Perinatal Care;perinatal medicine;perinatal mental health;personalized approach;Persons;Pharmacogenomics;Placental Biology;Plasma;Population;precision medicine;Pregnancy Complications;pregnancy health;Pregnancy Outcome;pregnant;Premature Birth;Prenatal Diagnosis;programs;Public Health;Race;racial diversity;racial population;recruit;Recruitment Activity;Reproductive Endocrinology;reproductive outcome;Research;Research Design;Research Infrastructure;Research Methodology;Research Personnel;Research Technics;Resources;Safety;San Francisco;Site;Smoke;success;Technology;Tissues;Training Programs;Translational Research;transplantation medicine;treatment program;Underrepresented Minority;Universities;Wildfire;Work

PROJECT_TITLE: Maternal Fetal Medicine Units Network: University of California, San Francisco


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

PHR: PROJECT NARRATIVE Mental, behavioral and neurological disorders are the primary cause of disability, measured as disability adjusted life years lost in the United States healthcare system. Magnetic resonance imaging (MRI) is central to our understanding of such disorders as one of the most powerful methods to study the human brain, but suffers from long exam times. In this work, we will develop and validate new techniques for rapid brain MRI using artificial intelligence tools.

PI_NAMEs: AKCAKAYA, MEHMET  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Algorithms;Anatomy;Area;Artificial Intelligence;Attention;Behavior Disorders;Behavioral;Brain;Brain imaging;BRAIN initiative;brain magnetic resonance imaging;Brain Mapping;Brain scan;Clinical Protocols;connectome;Data;Data Set;data space;Databases;deep learning;denoising;Development;Diagnosis;diagnostic value;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;disability;disability-adjusted life years;Disease;Evaluation;Face;Four-dimensional;Functional Magnetic Resonance Imaging;Future;Health Care Costs;Healthcare;Healthcare Systems;Human;Image;image processing;image reconstruction;imaging modality;improved;Individual;Learning;learning strategy;Magnetic Resonance Imaging;Maps;Measures;Memory;Mental disorders;Methodology;Methods;millimeter;Minnesota;Modeling;Morphologic artifacts;MRI Scans;Nervous System Disorder;neural network;Neurologic;Neurons;neuropsychiatry;novel;palliative;Pathology;Patients;Performance;Physics;Play;Process;Protocols documentation;Psyche structure;rapid technique;reconstruction;Recovery;Research;Resolution;Role;Sampling;Scanning;self supervised learning;Series;spatiotemporal;Speed;Structure;Symptoms;Techniques;Technology;technology development;theories;Time;tool;Training;training data;Translations;Uncertainty;United States;Universities;Validation;Work;years of life lost

PROJECT_TITLE: Robust and Efficient Learning of High-Resolution Brain MRI Reconstruction from Small Referenceless Data

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative Brucellosis is a world-widespread disease of animals and humans inflicting significant public health burden worldwide, which is caused by the zoonotic bacterial pathogen Brucella. Brucella resides and proliferates within host cells during infection, by injecting proteins that modulate cell functions to the bacterium’s advantage. This proposal aims to characterize how several of these proteins work together to promote two key events of Brucella pathogenesis, generation of a protective intracellular niche and bacterial proliferation, which will advance our knowledge of the disease process.

PI_NAMEs: CELLI, JEAN A (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Address;Animal Diseases;Area;Bacteria;Bacterial Infections;Biochemical;Biogenesis;Biological Process;Brucella;Brucella abortus;Brucellosis;Cell Physiology;Cells;Cellular biology;Communicable Diseases;Data;Disease;Endoplasmic Reticulum;Endosomes;Ensure;Event;Generations;Genetic;Goals;Golgi Apparatus;Golgi Targeting;Human;Infection;Intracellular Membranes;Knowledge;Life Cycle Stages;Maintenance;Mediating;Membrane;Membrane Protein Traffic;Methodology;microbial;microorganism;Modeling;Molecular;Natural Immunity;Nutrient;Organelles;Parasites;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathway interactions;permissiveness;Play;Process;Proliferating;Proteins;Public Health;Research;retrograde transport;Role;Testing;Toxin;trafficking;trans-Golgi Network;Transmembrane Transport;Type IV Secretion System Pathway;Vacuole;vesicle transport;Virulence;Widespread Disease;Work;Zoonoses

PROJECT_TITLE: Remodeling of intracellular membrane traffic by Brucella effectors

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Mental Health

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PUBLIC HEALTH RELAVENCE There is a need to develop improved treatments for HIV patients. The studies proposed here will evaluate a novel treatment strategy that uses NK cells to target a reservoir of HIV within lymphoid tissues. This therapy has the potential to achieve durable suppression of HIV.

PI_NAMEs: MORIARITY, BRANDEN S;SKINNER, PAMELA J (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Adoptive Transfer;Allogenic;Antigens;Autologous;B-Lymphocytes;BLR1 gene;cancer therapy;CAR T cell therapy;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Physiology;cell type;Cells;chemokine;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Clinical;Communicable Diseases;comparative efficacy;CRISPR/Cas technology;cytokine;Cytotoxic T-Lymphocytes;Data;Development;Disease remission;DNA;Dose;effective therapy;engineered NK cell;Engineering;experience;Genome engineering;Goals;graft vs host disease;HIV;HIV Infections;HIV-1;Homing;Human;Immune;immunoengineering;Immunotherapy;improved;In Vitro;in vivo;individual patient;insight;interest;Intervention;Knock-out;Lymphoid Follicle;Lymphoid Tissue;Macaca;Macaca mulatta;manufacture;manufacturing cost;manufacturing process;Methods;migration;Modeling;Natural Killer Cells;nonhuman primate;novel;Patients;pre-clinical;preconditioning;Process;programmed cell death protein 1;Protocols documentation;Public Health;Reagent;Recombinant adeno-associated virus (rAAV);Regimen;Research;response;Risk;RNA;Safety;Signal Transduction;Site;SIV;T-Cell Receptor;T-Lymphocyte;Test Result;Testing;Therapeutic Uses;trafficking;Transgenic Organisms;treatment strategy;tumor;Viral;Viral Load result;Viral Physiology;viral rebound;Viral reservoir;Viremia;Virus;Virus Replication

PROJECT_TITLE: Activated NK CAR Cells to Cure HIV


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Reactive oxygen species (ROS) are proposed to underlie the toxicity of important antibiotics and antitumor agents, but these ideas have been challenged by contrary data and concerns about methodologies. The mechanisms of drug actions must be understood so that the drugs can be improved. This project will provide strategies to determine whether ROS play important roles in cell damage.

PI_NAMEs: IMLAY, JAMES A. (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Anaerobic Bacteria;Anti-Bacterial Agents;anti-tumor agent;Antibiotics;Antioxidants;assault;Attention;Awareness;Bacteria;Binding;Biological;Biological Phenomena;cell injury;Cells;Chemical Actions;Clinical;Communities;Cytoprotection;Data;Deaminase;Defect;detection method;Diagnosis;DNA;DNA Damage;DNA Repair Inhibition;Dose;drug action;Dyes;Enzymes;Equipment;Escherichia coli;experience;experimental study;Fluorescein;Fluorescence;Fluorescent Dyes;Herbicides;Hydro-Lyases;Hydrogen Peroxide;Hydroxyl Radical;Immune system;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Injury;Iron;Lead;Literature;Measurement;Metabolic stress;metalloenzyme;Metals;Methodology;Methods;Microbiology;Modeling;Molecular;Morphologic artifacts;Natural Products;novel;Nutrient;Organism;Oxidants;oxidation;Oxidation-Reduction;oxidative damage;Oxidative Stress;Oxygen;Paper;Paraquat;Pharmaceutical Preparations;Phenazines;Play;Poison;Positioning Attribute;Production;Protocols documentation;Publishing;Quinones;Reaction;Reactive Oxygen Species;repaired;Role;sensor;Serine;Side;side effect;Signal Transduction;Site;skills;small molecule libraries;Starvation;Stress;Structure;Suggestion;Sulfur;Superoxides;System;Techniques;Testing;therapy design;Thymine;Toxic Actions;Toxic effect;Trimethoprim;United States National Institutes of Health;Variant;Voice;Work

PROJECT_TITLE: Diagnosing reactive oxygen species in bacteria

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Brain Disorders;Dental, Oral, and Craniofacial Disease;Down Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD)

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: Project narrative Mitochondria provide energy for cell function. Environmental insults like fluorosis or genetic diseases like Down syndrome (DS) affect mitochondria but how they affect the mitochondria of ameloblasts causing enamel defects is poorly understood. We will address this in DS mouse models and in newly developed reporter mice segregating enamel developmental stages treated with fluoride.

PI_NAMEs: LACRUZ, RODRIGO S. (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TERMS: Acquired Dental Fluorosis;Address;Adult;Affect;Ameloblasts;Amelogenesis;Anabolism;Apatites;Biogenesis;Biological Assay;bone;Brain;calcification;Calcium;Cell Line;Cell Physiology;Cells;Chromosome 21;Complex;Confocal Microscopy;Crystal Formation;Data;Defect;Dental caries;Dental Enamel;Development;Disease;dosage;Down's Syndrome;drinking water;Electron Transport;Enamel Formation;Exposure to;Fluorides;fluorosis;Foundations;Functional disorder;Funding;Generations;Genes;Genetic Diseases;Genus Hippocampus;Glycolysis;Goals;Growth;Heterozygote;high risk;Histology;Homeostasis;Human Chromosomes;human disease;Image;Impairment;improved;In Vitro;in vivo;Incisor;Individual;induced pluripotent stem cell;Intake;Knockout Mice;Label;Maturation-Stage Ameloblast;Measures;Mechanics;Membrane Potentials;Metabolic;mineralization;Minerals;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Matrix;mitochondrial membrane;mitochondrial metabolism;Modeling;Morphology;mouse model;Mus;Muscle;NADH;Nutrient;Oral health;Organelles;overexpression;Oxidation-Reduction;Oxygen Consumption;Pancreas;Patients;Play;Process;Production;Property;Protein Biosynthesis;Proteins;Reactive Oxygen Species;Recommendation;Regulation;Reporter;Reporting;response;Risk;Rodent;Role;Safety;segregation;Signal Transduction;single cell analysis;single-cell RNA sequencing;skeletal;Sorting;Structure;Testing;Tissues;Tooth structure;transcriptome;transcriptome sequencing;transcriptomic profiling;Trisomy;uptake

PROJECT_TITLE: Redox and Ca2+ signaling regulation of enamel mineralization


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Suicide;Violence Research;Youth Violence

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The alarming rise in youth suicide rates and attempts creates a tremendous public health burden yet, limited knowledge exists regarding the mechanisms associated with youth suicide in high risk groups which is imperative for primary prevention efforts. A parental history of suicidal behavior (SB) is associated with a 4-to- 6-fold increased risk of offspring SB and a younger age of onset for first suicide attempt. The objective of this study is to fill gaps in our current knowledge through examining, longitudinally, how parental history (PH status) is associated with trajectories of neurocognitive functioning (NF) and emotional reactivity/regulation (ERR), how NF and ERR constructs mediate the association between PH status and offspring SB and non-suicidal self-injury (NSSI), and test sex and race as moderators of the association between NF and ERR trajectories and offspring SB/NSSI.

PI_NAMEs: SHEFTALL, ARIELLE HOPE (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Adolescence;Adolescent;Age;age group;Age of Onset;age related;aged;Arousal;Arousal and Regulatory Systems;Attention;Behavioral;Biological;black men;Black race;black women;Cause of Death;Child;Childhood;cognitive control;cognitive system;cohort;computerized;Development;early onset;Emergency department visit;emotion dysregulation;Emotional;Enrollment;experience;externalizing behavior;Family;Feeling suicidal;Female;Functional disorder;Future;Goals;high risk;high risk population;Intervention;Interview;Knowledge;Learning;male;Measures;Mediating;Mediator;Mental Health;Methods;National Institute of Mental Health;Neurocognitive;Neurocognitive Deficit;non-suicidal self injury;offspring;Parents;Participant;Patient Self-Report;peer;Population Heterogeneity;Populations at Risk;Positive Valence;prevent;Prevention;Prevention strategy;Primary Prevention;Public Health;Race;racial disparity;racial population;Recording of previous events;recruit;Regulation;Research;Research Domain Criteria;Research Priority;Rewards;Risk;Risk Factors;Role;Sampling;sex;sex disparity;social communication;Social Processes;Strategic Planning;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide rate;System;Techniques;Testing;transmission process;trend;Visit;Youth

PROJECT_TITLE: Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Pancreatic cancer is projected to become the second leading cause of cancer-related death by 2030, yet there are no accurate diagnostic tests for early diagnosis. Our project will utilize real-time optical biopsies and artificial intelligence for early detection of pancreatic cancer arising from pancreatic cysts.

PI_NAMEs: KRISHNA, SOMASHEKAR G. (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Abdomen;accurate diagnostics;Adenocarcinoma;Agreement;Architecture;Artificial Intelligence;artificial intelligence algorithm;artificial neural network;Benign;Biopsy;BRAF gene;Cancer Etiology;cancer invasiveness;Cessation of life;Characteristics;Classification;clinical practice;Cohort Studies;Computer Models;convolutional neural network;current pandemic;Cyst;Cyst Fluid;Data;Decision Making;design;Detection;detection test;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic strategy;Diagnostic tests;Duct (organ) structure;Dysplasia;Early Diagnosis;Endoscopic Ultrasonography;Epithelium;Excision;Fine needle aspiration biopsy;follow-up;Goals;Guidelines;High grade dysplasia;Histopathology;Image;imaging biomarker;imaging study;improved;in vivo;International;Knowledge;KRAS2 gene;Lasers;learning strategy;Lesion;Malignant neoplasm of pancreas;Manuals;Methods;microendoscopy;Modality;model design;molecular marker;Morbidity - disease rate;mortality;Mucinous;Mucinous Neoplasm;Multicenter Studies;Mutation;Needles;next generation sequencing;novel diagnostics;novel strategies;Operative Surgical Procedures;Optical Biopsy;overtreatment;Pancreas;Pancreatectomy;Pancreatic Cyst;Pancreatic cystic neoplasia;Pancreatic Ductal Adenocarcinoma;Papillary;premalignant;progression risk;prospective;Reporting;Resected;Risk;risk stratification;Series;standard of care;Technology;Testing;Time;Unnecessary Surgery

PROJECT_TITLE: Endoscopic Ultrasound-guided In Vivo Confocal Laser Endomicroscopy as an Imaging Biomarker for the Accurate Risk Stratification of Intraductal Papillary Mucinous Neoplasms

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Gene Therapy with adeno-associated virus (AAV) vector has been successfully applied in hemophilia patients in recent clinical trials. However, these trials are excluded to patients with AAV neutralizing antibodies. In this application, we will explore novel approaches to evade AAV neutralizing antibodies for future human clinical trials in patients with hemophilia.

PI_NAMEs: LI, CHENGWEN  (contact);NICHOLS, TIMOTHY CHARLES

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Address;adeno-associated viral vector;Adoptive Transfer;analog;Animal Disease Models;Animal Model;Animals;Antibodies;Antigens;Automobile Driving;B-Lymphocytes;Binding;Biological;Blindness;Blocking Antibodies;Blood Component Removal;Body Temperature;Canis familiaris;Capsid;Cells;clinical application;Clinical Research;Clinical Trials;combinatorial;comparison control;Control Groups;Dependence;Dependovirus;Development;Disease;disease model;disease phenotype;Dose;Eligibility Determination;Engineering;Enzymes;Epitopes;Exclusion;exosome;Future;Gene Delivery;gene therapy;Hemophilia A;High Prevalence;Human;Immunization;Immunize;Immunoglobulin G;Immunoglobulins;improved;in silico;In Situ;In Vitro;in vivo;Individual;inhibitor;Intravenous Immunoglobulins;Libraries;Light;Mediating;Modification;multiple myeloma M Protein;Mus;Mutagenesis;mutant;Mycoplasma;neutralizing antibody;novel strategies;Nuclear;Patients;Pharmacological Treatment;Phenotype;Plasma;Population;prevent;Protein Conformation;Proteins;rational design;Role;Safety;Serotyping;Serum;side effect;Surface;Testing;therapeutic protein;tissue tropism;trafficking;Variant;vector;Virion;virus tropism

PROJECT_TITLE: Novel strategy to block Nabs for AAV gene delivery

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Chronic Pain;Clinical Research;Dissemination and Implementation Research;Pain Research;Patient Safety;Prevention

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative ………………………………… The number of older adults undergoing surgery in the United States is dramatically increasing and they are facing unique concerns with regards to pain management in the postoperative period as unnecessary prolonged use of pain medications can cause adverse drug events. The objective of this K23 proposal is to obtain an in-depth understanding of the patterns of prolonged use of postoperative pain medications for older adults and understand the barriers and facilitators that contribute to this prolonged use in order to refine a targeted, evidence-based intervention to prevent prolonged use of postoperative pain medication in older adults and then pilot this intervention. Ultimately, the information learned from this proposal will lead to the development of clinical interventions to improve the quality of life for older adults in the postoperative period.

PI_NAMEs: BONGIOVANNI, TASCE RIIKA SIMON (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: acceptability and feasibility;acute care;Address;Adopted;Adverse drug event;Adverse event;Age;Aging;Analgesics;Attention;Awareness;California;Capsicum;career;career development;Caregivers;Caring;Cessation of life;Clinical;clinical development;Communication;comorbidity;Consensus;Critical Care;Data;design;Drug Prescriptions;Ensure;Epidemiology;Evidence based intervention;experience;feasibility testing;Feedback;Foundations;Fright;Goals;Guidelines;Health system;Hospitalization;Hospitals;implementation science;implementation strategy;improved;insight;interest;Intervention;Interview;Knowledge;Lead;Leadership;Learning;Life;Medicare;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;multidisciplinary;multimodality;Muscle relaxants;non-opioid analgesic;older adult;Operative Surgical Procedures;Opioid;opioid epidemic;opioid sparing;Pain;Pain management;Pathway interactions;patient oriented;patient oriented research;patient population;Patients;Pattern;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Physicians;Population;Postoperative Care;Postoperative Pain;Postoperative Period;prescription opioid;prescription pain reliever;prevent;Public Health;Quality of life;Regimen;Research;Research Personnel;Risk;Risk Factors;San Francisco;Site;skills;Statistical Data Interpretation;Surgeon;Testing;Time;Training;Translational Research;Trauma;United States;Universities;Work

PROJECT_TITLE: Prolonged Use of Pain Medication Past the Postoperative Period in Older Adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Tailoring the most desired therapy to each individual patient is the primary goal of precision medicine. The proposed study aims to develop novel computational approaches to predict drug response and drug combination effects accurately.

PI_NAMEs: XIE, YANG  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Algorithms;Artificial Intelligence;Biological;Biological Assay;Characteristics;Chemicals;Collaborations;Communities;Complex;computer framework;Computer Models;Computing Methodologies;Consumption;Data;deep learning;Disease;drug action;Drug Combinations;drug mechanism;Drug Modelings;drug repurposing;drug response prediction;Drug Side Effects;Drug usage;Effectiveness;epigenomics;Genetic;Genomics;Goals;high dimensionality;Human Cell Line;improved;individual patient;insight;interest;Methodology;Molecular;Molecular Profiling;novel;Patients;Pattern;Pharmaceutical Preparations;Pharmacogenomics;precision medicine;predictive modeling;Research;response;Therapeutic;Time;user-friendly;web portal

PROJECT_TITLE: Novel computational approaches to predict drug response and combination effects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]