PI_NAMEs: WOLF, MATTHEW  (contact)

PROJECT_TERMS: 3-Dimensional;anti-tumor immune response;Area;Biocompatible Materials;Biological Response Modifiers;cancer cell differentiation;cancer immunotherapeutics;cancer immunotherapy;Cancer Patient;cancer therapy;Cancer Vaccines;Chemicals;Collagen;Drug resistance;Engineering;Environment;Excision;Extracellular Matrix;fighting;Goals;Immune;Immune response;Immune system;Immunity;Immunologic Adjuvants;Immunologic Stimulation;Immunooncology;immunoregulation;Immunotherapy;Impaired wound healing;in vivo;Maintenance;Malignant Neoplasms;Medicine;Modeling;Molecular;multidisciplinary;next generation;Organoids;Patients;Plastics;Process;Regenerative Medicine;Reporting;Role;scaffold;Science;Solid Neoplasm;Surgical Models;System;Therapeutic;Tissue Engineering;Tissues;tool;tumor;tumor immunology;vaccine immunotherapy;wound healing

PROJECT_TITLE: Cancer Biomaterials Engineering


ACTIVITY: ZIA

ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;HIV/AIDS;Infectious Diseases

ORG_NAME: DIVISION OF BASIC SCIENCES - NCI

PI_NAMEs: LEE, KYUNG  (contact)

PROJECT_TERMS: Acidic Region;Acquired Immunodeficiency Syndrome;Affinity Chromatography;Aneuploidy;Animal Model;Automobile Driving;Binding;Biochemical;Biological;Biological Assay;Blood;C-terminal;carcinogenesis;CD4 Positive T Lymphocytes;Cell Cycle;Cell model;Cells;cellular targeting;Centrioles;Centrosome;chromosome missegregation;comorbidity;Complex;Cryoelectron Microscopy;Cultured Cells;Development;Elements;Event;Exhibits;Genome Stability;Goals;high risk;HIV-1;Human;Immune system;Incidence;Infection;Investigation;Link;Malignant Neoplasms;Molecular;mutant;Nature;novel strategies;Organelles;Pathogenesis;Persons;Phosphotransferases;Physiological;PLK1 gene;Predisposition;Procentriole;Process;Proteins;Proteomics;Research;Risk;Role;scaffold;Shapes;Structure;T-Cell Lymphoma;tumorigenesis;ubiquitin-protein ligase;X-Ray Crystallography

PROJECT_TITLE: Unraveling the molecular link between HIVAIDS and cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: FRANCHINI, GENOVEFFA  (contact)

PROJECT_TERMS: Adenosine;Adjuvant;aluminum sulfate;ALVAC;Antibodies;antibody-dependent cell cytotoxicity;Antigens;Apoptotic;beta pleated sheet;Binding;Blood;booster vaccine;CCR5 gene;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Clinic;Communicable Diseases;comparison control;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;DNA;DNA Vaccines;efficacy trial;Engineering;Epigenetic Process;Epithelium;Epitopes;Exposure to;Female;Government;gp160;Grant;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV vaccine;Human;Hydroxides;IL17 gene;Immune response;Immune system;Immunity;Immunologics;Infection;infection risk;Inflammation;Inflammatory;inhibitor;Intellectual Property;Interleukin-10;Invertebrates;Investigation;Lead;Legal patent;Licensing;Link;liposomal formulation;Macaca;Macrophage;Malignant Neoplasms;Mediating;Memory;Modeling;Molecular Conformation;Monoclonal Antibodies;monocyte;Mucous Membrane;Myeloid Cells;Natural Immunity;natural killer cell protein 44-kDa;Natural Killer Cells;Necrosis;neutralizing antibody;nonhuman primate;novel;novel vaccines;Nucleocapsid;pathogen;Phase;prevent;Private Sector;Production;programs;Proteins;QS21;Recombinants;Regimen;response;Rest;Risk;SIV;Surface;synergism;T cell response;T-Cell Activation;Testing;Thailand;Training;trait;Translating;user-friendly;Vaccinated;Vaccination;vaccine efficacy;vaccine platform;vaccine trial;Vaccines;Vaginal Gel;Vaginal Ring;virucide;Virus;Virus Diseases;Zinc

PROJECT_TITLE: Phase I HIV vaccine trial with DNAALVAC-HIV gp120 delta V1 vaccines


PI_NAMEs: GONATOPOULOS-POURNATZIS, THOMAS  (contact)

PROJECT_TERMS: Address;Alternative Splicing;Arginine;bioinformatics tool;Biological Assay;Cell Physiology;Cells;Clinical;clinically relevant;Code;Complex;Dedications;Disease;Engineering;Event;Exhibits;Exons;fitness;functional genomics;Gene Expression;Genes;Genetic;Genome;genome-wide;genomic platform;genomic tools;Genotoxic Stress;innovation;interdisciplinary approach;Investigation;Malignant Neoplasms;Messenger RNA;Modeling;Molecular Analysis;Molecular Target;Mutation;Neurodevelopmental Disorder;Outcome;Output;Patients;Phenotype;Process;programs;Proliferating;Protein Isoforms;Proteins;Renal Cell Carcinoma;repository;Research;RNA Splicing;screening;Serine;Splice-Site Mutation;Syndrome;TAF1 gene;TAF5 gene;Techniques;Technology;Tertiary Protein Structure;Transcription Initiation

PROJECT_TITLE: Identify and Characterize Phenotypically Relevant Alternatively Spliced Exons


PI_NAMEs: WU, CHUAN  (contact)

PROJECT_TERMS: Biological Response Modifiers;Cells;Chemicals;Communication;Complex;Cues;detection platform;Disease;Endocrine Glands;Enteric Nervous System;Environment;Esthesia;experience;Gastrointestinal Diseases;gut-brain axis;Homeostasis;Host Defense;Immune;Immune system;intestinal barrier;intestinal homeostasis;Intestinal Mucosa;Intestines;Irritable Bowel Syndrome;microbiota;Molecular;Nerve;Nervous System;Neurons;neuroregulation;Neurosecretory Systems;Organ;Physiology;Process;response;Sensory;Signal Transduction;Synaptic Transmission;System;Tissues;Translations;Work

PROJECT_TITLE: Immune-neuron crosstalk regulates intestinal homeostasis


PI_NAMEs: WU, COLIN  (contact)

PROJECT_TERMS: Address;Apoptotic;Attention;Biochemical;Biogenesis;Biological Assay;Biological Process;Cell Death Induction;Cells;Cellular Stress;Cessation of life;Chemicals;CRISPR screen;Cues;Dissection;DNA Sequence Alteration;Gene Expression;Generations;Genetic Induction;genetic information;genome-wide;Goals;Human;Learning;Life;Mass Spectrum Analysis;Molecular;novel;Operon;Output;Pathway interactions;Process;programs;Proteins;Research;response;Ribosomal DNA;Ribosomal RNA;ribosome profiling;Ribosomes;Stress;System;Techniques;Translations

PROJECT_TITLE: Noncanonical functions of the ribosome in response to cellular stress


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orthopoxviruses;Rare Diseases;Vaccine Related

PI_NAMEs: MAYER, CHRISTIAN  (contact)

PROJECT_TERMS: Antibodies;Antibody Response;Biological Assay;cross reactivity;design;Enzyme-Linked Immunosorbent Assay;Goals;Human;improved;Individual;Knowledge;Laboratories;Monkeypox virus;Research;Techniques;Therapeutic;unvaccinated;Vaccinated;Vaccines;Vaccinia;Viral Proteins;Virus

PROJECT_TITLE: Antibody responses to viruses


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Immunotherapy;Infant Mortality;Pediatric;Pediatric Cancer;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: PAI, SUNG-YUN  (contact)

PROJECT_TERMS: Active Sites;Allogenic;Antibodies;Area;arm;Autologous;B-Lymphocytes;Bacteria;Blood;Blood donor;Bone Marrow;Boston;Busulfan;Canada;Cell Count;Cell Physiology;Cell Therapy;Cells;Cessation of life;chemotherapy;Child;Codon Nucleotides;conditioning;cytokine;Defect;design;Development;Disease;Dominant-Negative Mutation;Dose;Early Diagnosis;Enrollment;fighting;fungus;gene therapy;Gene therapy trial;Generations;Genes;Genetic;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Human Herpesvirus 4;Human Papillomavirus;IL2RG gene;Immune;immune reconstitution;Immune system;immunodeficiency;Immunoglobulin Gene Rearrangement;Immunoglobulins;Immunologics;In Vitro;Infant;Infection;Institution;JAK3 gene;Lead;Lentivirus Vector;Longevity;Lymphocyte Function;Lymphoma;Malignant Neoplasms;microorganism;Molecular;Morbidity - disease rate;mortality;mutant;Mutation;Natural Killer Cells;Oncogenic Viruses;Opportunistic Infections;Organism;participant enrollment;Patients;Pediatric Hospitals;Peptide Elongation Factor 1;peripheral blood;Persons;Plasmablast;Predisposition;prevent;Prior Chemotherapy;Production;promoter;Proteins;Protocols documentation;Randomized;Regimen;response;Risk;Safety;Sampling;Severe Combined Immunodeficiency;Signal Transduction;Site;standard care;System;T cell reconstitution;T-Cell Receptor Genes;T-Lymphocyte;Testing;Tissues;Toxic effect;Transgenes;tumor;Umbilical Cord Blood;United States;Viral;Virus;X-Linked Severe Combined Immunodeficiency

PROJECT_TITLE: Pathobiology and treatment of patients with severe combined immunodeficiency


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Eczema / Atopic Dermatitis;Gene Therapy;Genetics;Hematology;Immunotherapy;Infectious Diseases;Pediatric;Prevention;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PROJECT_TERMS: Actins;Affect;Alkylating Agents;Allogenic;Area;Autoimmunity;Autologous;autosome;B-Lymphocytes;Biology;Blood Platelets;Bone Marrow Purging;Boston;Cell Cycle Kinetics;Cell Lineage;Cell model;Cell Physiology;Cell Therapy;cell type;Cells;Child;Chimerism;Clinical;Clinical Protocols;Clinical Trials;Codon Nucleotides;Complex;conditioning;congenital immunodeficiency;Cytoskeleton;Data;design;Development;Disease;DOCK8 deficiency;Eczema;Engraftment;Enrollment;Food Hypersensitivity;gene therapy;Gene therapy trial;Gene Transfer;Genes;Goals;Health;Hematology;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hereditary Disease;Human;Human Herpesvirus 4;Human Papillomavirus;IgE;Immune;immune function;immune reconstitution;Immunity;immunodeficiency;Immunologic Deficiency Syndromes;improved;In Situ;Infection;Infection prevention;insight;intein;interest;irradiation;Knowledge;Laboratories;Length;Lentivirus Vector;Life;Link;Location;Lymphoma;Malignant Neoplasms;manufacture;monocyte;Mutation;Myeloid Cells;Natural Killer Cells;next generation;novel;novel strategies;Oncogenic Viruses;Outcome;Pathogenesis;Patients;Pattern;pre-clinical;Predisposition;prevent;promoter;Proteins;Publications;Publishing;reconstitution;reduce symptoms;Regimen;Regulatory Element;Severe Combined Immunodeficiency;side effect;Site;Symptoms;T cell regulation;T-Cell Development;T-Lymphocyte;Technology;Testing;Thrombocytopenia;Toxic effect;Trans-Splicing;transduction efficiency;transgene expression;Transgenes;Transplantation;vector;Vertebral column;Viral;Viral Vector;Virus Integration;Wiskott-Aldrich Syndrome;young adult

PROJECT_TITLE: Pathobiology and treatment of patients with inborn errors of immunity


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: ALEWINE, CHRISTINE  (contact)

PROJECT_TERMS: Acinar Cell Carcinoma;Affect;Area;cancer diagnosis;CCR;Cells;chemotherapy;Clinical;Clinical Research;Clinical Trials;Collaborations;Correlative Study;disease model;Engineering;Exocrine pancreas;Extramural Activities;Genetic Transcription;Goals;Histologic;Histology;Human;Immune;improved outcome;inhibitor;Intervention;Malignant neoplasm of pancreas;Molecular;Molecular Profiling;Mus;Natural History;Neoplasm Metastasis;overexpression;Pancreas;pancreatic cancer cells;Pancreatic carcinoma;Pancreatic Ductal Adenocarcinoma;Pancreatic Exocrine Neoplasm;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;phase II trial;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Pre-Clinical Model;Prognosis;programs;prospective;rare cancer;Reporting;Research;Research Personnel;Sampling;Site;small molecule;Solid Neoplasm;Squamous Differentiation;Testing;Therapeutic;tumor;Variant;Work

PROJECT_TITLE: Rare Exocrine Tumors of the Pancreas


PI_NAMEs: SINGER, DINAH S. (contact)

PROJECT_TERMS: Binding;Chromatin Loop;Development;DNA Methylation;DNA Modification Process;DNA Sequence Alteration;Elements;Epigenetic Process;fly;Frequencies;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Genomic Imprinting;Goals;histone modification;in vivo;Inheritance Patterns;insight;Link;Mammals;Mediating;Metabolic;MHC Class I Genes;Modification;Molecular;Mutation;Nucleosomes;Pattern;Phenotype;Plants;programmed cell death protein 1;promoter;Regulation;Reporting;RNA;Stress;Time;Tissues;trait;Trans-Activators;transgenerational epigenetic inheritance;Transgenes;Transgenic Organisms;transmission process;Untranslated RNA

PROJECT_TITLE: Transgenerational Epigenetic Inheritance Mediated by a Core Promoter Element


PI_NAMEs: LEA, SUSAN  (contact)

PROJECT_TERMS: Antibiotics;Bacteria;Cryoelectron Microscopy;Cytoplasm;Disease;Enzymes;Flagella;Future;Gastrointestinal tract structure;Goals;Health;Helicobacter pylori;Human;Medical;Methods;Microbiology;Molecular;Molecular Conformation;Multiprotein Complexes;Nature;novel;pathogen;Pathway interactions;Process;Protein Conformation;Publishing;Research;Rotation;structural biology;System;Work;X-Ray Crystallography

PROJECT_TITLE: Structural biology of host-pathogen interactions


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PI_NAMEs: ISHII, KAZUSA  (contact)

PROJECT_TERMS: Address;Antigen Presentation;Antigen Targeting;Antigens;B lymphoid malignancy;B-Cell Leukemia;cancer cell;CAR T cell therapy;CD19 gene;CD22 gene;Cell Line;cellular transduction;chimeric antigen receptor;chimeric antigen receptor T cells;clinical translation;cross reactivity;cytokine;Data;Disease;Disease remission;disorder subtype;early phase clinical trial;engineered T cells;Goals;Hematologic Neoplasms;Hematological Disease;Hematology;HLA-A gene;HLA-A2 Antigen;Immunotherapeutic agent;in vivo;Inflammatory;interest;International;Legal patent;leukemia;leukemia/lymphoma;Leukemic Cell;Lymphoma;Lymphoma cell;Malignant lymphoid neoplasm;manufacture;Mediating;novel;Oncology;Patients;Peptide Fragments;pre-clinical;Process;programs;Resistance;resistance mechanism;Risk;Safety;Science;screening;Surface Antigens;synergism;systemic inflammatory response;T cell therapy;T-Cell Receptor;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Toxic effect;tumor;Tumor Antigens;Tumor Escape;vector;Virus;Xenograft Model

PROJECT_TITLE: TCR engineered T cell therapies for hematologic malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: THIELE, CAROL J (contact)

PROJECT_TERMS: Address;Affect;Automobile Driving;Bar Codes;Binding;Biological Models;Blood Vessels;Cell Line;Cell Therapy;cell type;Cells;Companions;Complex;DNA Sequence Alteration;DNA sequencing;Drug Screening;Ecosystem;Environment;Epigenetic Process;Evolution;Genetic;Genetic study;Genomics;Growth;Heterogeneity;high risk;Immune;immunoregulation;In Vitro;in vitro Model;in vivo Model;insight;interest;Intervention;Modeling;Molecular;Mus;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;neuroblast;Neuroblastoma;Normal tissue morphology;novel;Phenotype;Population Heterogeneity;pressure;prevent;Proteomics;Refractory;Relapse;Research Personnel;response;Saint Jude Children's Research Hospital;SCID Beige Mouse;Serum;single cell ATAC-seq;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;therapy resistant;Tissues;transcriptome sequencing;treatment response;tumor;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Subtype;tumorigenesis;Xenograft Model

PROJECT_TITLE: Neuroblastoma Tumor Microenvironment: tumor growth and immune regulation


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Emerging Infectious Diseases;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases;Skin Cancer

PI_NAMEs: ZIEGELBAUER, JOSEPH  (contact)

PROJECT_TERMS: Affect;Africa South of the Sahara;angiogenesis;Anti-Inflammatory Agents;Antigen Presentation;Area;Automobile Driving;B-Cell Lymphomas;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Biological Assay;Biological Markers;Biopsy;CD4 Positive T Lymphocytes;Cell Count;Cell Culture Techniques;cell killing;Cell model;cell type;Cells;Characteristics;chemokine;chemotherapy;Clinical;clinically relevant;co-infection;Collaborations;Cutaneous;CXCL10 gene;cytokine;Data;Detection;Development;Diagnosis;Diagnostic Procedure;differential expression;Disease;Disease remission;Endothelial Cells;Environment;Etiology;experimental study;FLT4 gene;gastrointestinal;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;healing;Heterogeneity;HIV;HIV Infections;HIV Seropositivity;Human;Human Herpesvirus 4;Human Herpesvirus 8;IL6 gene;Immune;Immune response;Immunocompromised Host;immunodeficiency;improved;In Vitro;Individual;Infection;Infiltration;Inflammation;Inflammatory;Inflammatory Response Pathway;insight;Interferon Type II;Interleukin-10;Investigation;Kaposi Sarcoma;KDR gene;Knowledge;Lesion;Location;Lung;Lymphatic Endothelial Cells;Lymphoproliferative Disorders;Lytic;Macrophage;Malignant Neoplasms;memory CD4 T lymphocyte;Methods;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;Normal tissue morphology;novel diagnostics;novel therapeutic intervention;organ transplant recipient;Participant;Pathogenesis;Pathologic;Patients;Pattern;Persons;Phagocytosis;Play;Population;post-transplant;preference;primary effusion lymphoma;Production;progression risk;Publishing;Regulatory T-Lymphocyte;Rest;Risk;RNA;Role;Sampling;Site;Skin;Skin Kaposi's Sarcoma;skin lesion;Specimen;STC1 gene;targeted treatment;Therapeutic;Tissues;Transcript;transcriptome sequencing;treatment strategy;tumor;tumor microenvironment;tumorigenesis;United States;Vascular Endothelial Growth Factor Receptor-3;Viral;Viral Genes;Viral Load result;Virion;Virus;virus host interaction

PROJECT_TITLE: Virus host interactions in clinical samples


PI_NAMEs: GOTTESMAN, MICHAEL  (contact)

PROJECT_TERMS: ABCB1 gene;ABCG2 gene;Adult;Antibodies;Astrocytes;ATP-Binding Cassette Transporters;Biological Assay;Biological Models;Blood;Blood - brain barrier anatomy;blood-brain barrier crossing;blood-brain barrier permeabilization;Brain;brain endothelial cell;brain tissue;Caring;Categories;Cells;Cerebrovascular system;coelenterazine;Collaborations;Consumption;cytotoxicity;Data;deep ocean;Drug Delivery Systems;Drug or chemical Tissue Distribution;Drug resistance;Firefly Luciferases;Fishes;Gastrointestinal tract structure;Generations;Genes;Glial Fibrillary Acidic Protein;Goals;high throughput analysis;high throughput screening;Homologous Gene;Human;improved;In Situ Hybridization;inhibitor;Kidney;Knock-out;Knockout Mice;Light;Liver;Luciferases;luciferin;Malignant Neoplasms;Measures;model organism;Modeling;Monitor;mouse model;Mus;nanoluciferase;National Center for Advancing Translational Sciences;Nature;novel;Orthologous Gene;Pattern;Penetration;Permeability;Placenta;Play;prevent;Promega;promoter;Property;Reaction;Resistance;Role;Shrimp;Signal Transduction;Site;Spinal Cord;Stains;Study models;Substrate Specificity;System;Testing;Time;Transgenic Organisms;Variant;Water;Zebrafish

PROJECT_TITLE: Zebrafish model of blood-brain barrier to improve drug delivery to the brain


NIH_SPENDING_CATS: Cancer;Clinical Research;Orphan Drug;Rare Diseases

PI_NAMEs: ROPER, NITIN  (contact)

PROJECT_TERMS: Adrenocortical Carcinoma;biobank;Cell Line;Clinic;Drug Screening;drug testing;drug use screening;Future;Genomics;Goals;molecular subtypes;Neuroendocrine Tumors;novel therapeutic intervention;novel therapeutics;Organoids;Patients;pharmacologic;Pre-Clinical Model;Prognosis;The Cancer Genome Atlas;Therapeutic;Therapeutic Studies;Translating;tumor;tumor heterogeneity

PROJECT_TITLE: Developing ACC patient-derived organoids to identify therapeutic vulnerabilities


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Microbiome;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS;Women's Health Research

PI_NAMEs: BERZOFSKY, JAY A (contact)

PROJECT_TERMS: Acute;Adjuvant;Affect;Affinity;Agonist;aluminum sulfate;ALVAC;Animals;anti-PD-L1;Antibiotics;Antibodies;Antigens;Avidity;Back;base;Binding;Blood Platelets;cancer immunotherapy;Cancer Vaccines;carboxypeptidase C;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Aggregation;Cell Line;Cells;chemokine receptor;Citrobacter;Clinical Trials;Colitis;Collaborations;Colon;Cross Presentation;cytokine;Cytoprotection;Cytotoxic T-Lymphocytes;Data;design;DNA;Dose;Endosomes;Epigenetic Process;Epitopes;Exclusion;Fertilization;Funding;Genes;Genetic Transcription;Glycocalyx;Goals;gp160;Granulocyte-Macrophage Colony-Stimulating Factor;gut microbiota;Gut Mucosa;Helper-Inducer T-Lymphocyte;Histocompatibility;HIV;HIV Envelope Protein gp120;HIV Infections;HIV vaccine;HIV/SIV vaccine;Home;Homing;Human;IL17 gene;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immunity;Immunization;Immunodominant Epitopes;Immunoglobulin A;Immunology;Immunotherapy;imprint;improved;in vivo;Infection;Interferon Type II;Interferons;Interleukin-12;Interleukin-15;interleukin-21;invention;knock-down;Large Intestinal Mucosa;Large Intestine;Ligands;lymphoid structures;Macaca;Malignant Neoplasms;Melanoma patient;Memory;microbicide;microbiome;Modeling;Modification;monocyte;Mucosal Immunity;mucosal vaccine;Mucous Membrane;Mus;Myeloid-derived suppressor cells;nanoparticle;nanoparticle delivery;Natural Immunity;novel;novel strategies;Oral;OVA-8;PF4 Gene;Phase;Plasma Cells;Plasmablast;PPBP gene;Predisposition;prevent;Production;Proteins;receptor expression;Rectum;Regulation;Regulatory T-Lymphocyte;Research;response;Risk;Role;Safety;simian human immunodeficiency virus;single-cell RNA sequencing;Site;SIV;SIV Vaccines;Small Intestines;STAT1 gene;Stomach;Structure;Surface;synergism;T cell response;T-Cell Depletion;T-Lymphocyte;Testing;Textbooks;Time;TLR3 gene;Toll-like receptors;trafficking;Training;transcriptome sequencing;Transforming Growth Factor beta;Transgenic Mice;Translating;Translations;transmission process;Tretinoin;Vaccine Adjuvant;vaccine delivery;Vaccine Design;vaccine efficacy;vaccine immunogenicity;vaccine strategy;Vaccines;Vaccinia virus;Vagina;vaginal mucosa;Viral;Viral Antigens;viral detection;Viral Load result;viral transmission;Virus;Virus Diseases;Work

PROJECT_TITLE: Vaccine strategies for HIVAIDS


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: DAVIES, ERIN  (contact)

PROJECT_TERMS: Address;Adult;Algorithms;Anatomy;Animals;Atlases;Behavior;Bioinformatics;Biological Markers;CCR;cell fate specification;Cell Lineage;cell type;Cells;comparative;Data;Data Analyses;Data Set;Development;differential expression;digital;Dissociation;Dyes;Embryonic Development;Female;Fluorescence-Activated Cell Sorting;Gene Expression;Genes;Genetic Transcription;Germ Cells;germline stem cells;Heterogeneity;Homeostasis;In Situ Hybridization;in vivo;Laboratories;Lead;male;marine;Morphology;Natural regeneration;Nuclear;Platyhelminths;Pluripotent Stem Cells;Postdoctoral Fellow;Postembryonic;Preparation;programs;Protocols documentation;regenerative;Regulation;Reporting;Reproductive system;research facility;Resources;Sampling;Scientist;Sexual Maturation;single-cell RNA sequencing;Specific qualifier value;Stains;System;Technology;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Anatomical and gene expression resource for Macrostomum lignano


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: MCEACHRON, TROY  (contact)

PROJECT_TERMS: Adolescent;Area;ATAC-seq;Automobile Driving;Biological Process;Bone neoplasms;Cell Nucleus;Cells;cellular targeting;Childhood;Clinical Research;clinical translation;Complex;CRISPR interference;CRISPR-mediated transcriptional activation;cytotoxic;Data;Data Analyses;data integration;Diagnosis;Disease;disease model;Disease Progression;DNA Sequence Alteration;Exclusion;Genetic;Genomics;Growth;Heterogeneity;Immune Evasion;Immune response;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;Individual;Infiltration;Inflammatory;Lesion;Localized Disease;Lung;Lymphocyte;Lymphocytic Infiltrate;Medical;Metastatic Osteosarcoma;Metastatic to;Modality;Molecular;Molecular Target;mouse model;Neoplasm Metastasis;neoplastic cell;Non-Malignant;Nonmetastatic;Osteosarcoma;Pathway interactions;Patients;pharmacologic;Population;Process;Proteomics;Research;response;Specimen;Supporting Cell;Survival Rate;Therapeutic;Therapeutic Agents;therapy resistant;Tissues;transcriptome sequencing;transcriptomics;Treatment Efficacy;tumor;young adult

PROJECT_TITLE: Identification of immune evasion mechanisms in the osteosarcoma microenvironment


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

PI_NAMEs: RAJAGOPAL, PADMA  (contact)

PROJECT_TERMS: Algorithms;American Association of Cancer Research;Biological;brca gene;BRCA mutations;cancer clinical trial;cancer type;Cell Line;Cell Survival;Cells;Cessation of life;chemotherapy;Clinical;Clinical Data;Clinical Trials;clinically relevant;Code;Computational algorithm;Confidence Intervals;Data;Data Set;Dependence;Disease;Disease-Free Survival;Drug Targeting;Eligibility Determination;ERBB2 gene;Event;evidence based guidelines;Gene Expression;gene interaction;Genes;Genetic;genetic testing;Germ Lines;Goals;Guidelines;hazard;Immunotherapy;immunotherapy trials;improved;In Vitro;in vivo;Individual;large scale data;Lethal Genes;Literature;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Maps;Mediating;mutation carrier;Names;National Comprehensive Cancer Network;olympia;oncotype;overtreatment;patient response;Patients;Performance;Phylogenetic Analysis;placebo group;Poly(ADP-ribose) Polymerase Inhibitor;Population;precision oncology;predicting response;Prediction of Response to Therapy;preservation;prognostic value;prognostication;Proteins;Recommendation;Regimen;responders and non-responders;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;Step Tests;symposium;targeted therapy trials;targeted treatment;Testing;Training;transcriptome;transcriptome sequencing;treatment responders;triple-negative invasive breast carcinoma;Validation;Work

PROJECT_TITLE: Leveraging RNA and synthetic lethality in germline BRCA-mut breast cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Immunotherapy;Precision Medicine;Women's Health Research

PROJECT_TERMS: advanced breast cancer;advanced disease;Algorithms;Biological Markers;Biopsy;cancer clinical trial;CCR;Characteristics;Clinical;Clinical Data;Clinical Trials;cohort;Consent;Data;Death Rate;Disease;DNA;DNA sequencing;Enrollment;exome;Face;FDA approved;Frequencies;Frustration;Funding;genomic data;Germ Lines;Guidelines;Immune Sera;Immunotherapy;Institutional Review Boards;Label;Malignant Breast Neoplasm;Metastatic breast cancer;Methylation;molecular pathology;Mutation;objective response rate;open label;Participant;Patient Outcomes Assessments;patient population;patient subsets;Patients;Performance;peripheral blood;precision oncology;Progression-Free Survivals;Recommendation;Refractory;response;Review Committee;Risk Assessment;RNA;Symptoms;targeted treatment;Therapeutic;Tissues;transcriptome sequencing;transcriptomics;Translational Research;Treatment-related toxicity;triple-negative invasive breast carcinoma;tumor;tumor DNA;tumor microenvironment

PROJECT_TITLE: Identifying Treatment Options using RNA-Based Synthetic Lethality and Rescue


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: NELLAN, ANANDANI  (contact)

PROJECT_TERMS: Address;Affect;Antigen Targeting;Antigens;Brain Neoplasms;cancer cell;cancer infiltrating T cells;CAR T cell therapy;Cause of Death;CCL2 gene;Cell secretion;Central Nervous System Neoplasms;chemokine;chemotherapy;Child;Childhood Brain Neoplasm;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;combinatorial;Communication;cytokine;Cytotoxic Chemotherapy;cytotoxicity;Down-Regulation;Effectiveness;effector T cell;Ependymoma;ERBB2 gene;Excision;experience;extracellular;falls;Fourth ventricle structure;Generations;Genes;Genetic Transcription;Harvest;Hematologic Neoplasms;Heterogeneity;high risk;high risk population;immune activation;Immune system;Immunosuppression;Immunotherapy;Impairment;Implant;improved;Infiltration;Inflammatory;Inflammatory Infiltrate;Intervention;Intravenous;Learning;Ligands;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Medulloblastoma;monocyte;mouse model;Mus;Nature;neoplastic cell;NF-kappa B;novel;Nuclear Translocation;Operative Surgical Procedures;patient derived xenograft model;Patients;Pediatric Neoplasm;Phenotype;Poly-fluoroalkyl substances;Posterior Fossa;pre-clinical;preclinical efficacy;preclinical study;Proteins;Publishing;Radiation;receptor;Recurrence;Recurrent disease;Refractory;Regulatory T-Lymphocyte;RELA gene;Relapse;Research;Resistance;resistance mechanism;response;Role;Sampling;Serum;Solid Neoplasm;standard of care;Stimulus;success;T-Cell Receptor Therapy;T-Lymphocyte;TNF gene;Trastuzumab;tumor;tumor eradication;tumor heterogeneity;tumor-immune system interactions;young adult

PROJECT_TITLE: Study of CAR T cells and mechanisms of resistance in pediatric brain tumors


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Prostate Cancer;Radiation Oncology;Urologic Diseases

PI_NAMEs: TURKBEY, BARIS  (contact)

PROJECT_TERMS: accurate diagnosis;accurate diagnostics;Address;Algorithms;Area;Artificial Intelligence;Biopsy;burden of illness;cancer care;Cancerous;clinical practice;Clinical Trials;diagnostic accuracy;Diagnostic Neoplasm Staging;Evaluation;Focused Ultrasound Therapy;Future;Image;image guided;Image Guided Biopsy;image processing;improved;innovation;Magnetic Resonance Imaging;Malignant neoplasm of prostate;molecular imaging;Morphologic artifacts;novel imaging technique;patient variability;Patient-Focused Outcomes;personalized medicine;Procedures;prostate biopsy;Prostate Cancer therapy;Protocols documentation;Research;Resolution;Screening for Prostate Cancer;System;Techniques;Technology Transfer;Tissues;treatment planning

PROJECT_TITLE: Imaging, image guided biopsy and treatment of prostate cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Patient Safety;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: KANAKRY, JENNIFER  (contact)

PROJECT_TERMS: Abbreviations;Allogenic;Amendment;American;Antithymoglobulin;Cell Therapy;Cells;Clinical;Clinical Trials;Clinical Trials Data Monitoring Committees;conditioning;Correlative Study;Data Analyses;Disease;disorder control;Distal;efficacy evaluation;Engraftment;Enrollment;Equus caballus;Goals;graft vs host disease;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;HIV;immune reconstitution;Infection;Infection Control;Infection prevention;Kinetics;Malignant Neoplasms;Manuscripts;novel;novel strategies;Oral;Organ;Patients;Peripheral;pharmacokinetics and pharmacodynamics;Process;Prophylactic treatment;Publishing;Radiation;Regimen;Societies;T-Cell Lymphoma;Toxic effect;Transplant Recipients;transplantation therapy

PROJECT_TITLE: Reduced toxicity allogeneic hematopoietic cell transplantation in malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: NGUYEN, HONG HA ROSA  (contact)

PROJECT_TERMS: Antibodies;Area;Cancer Therapy Evaluation Program;CAR T cell therapy;Cellular immunotherapy;Childhood Solid Neoplasm;Clinical Research;Clinical Trials;CRISPR screen;Cytokine Gene;Development;Engineering;first-in-human;genome-wide;Goals;Immunotherapy;innovation;Laboratories;Natural Killer Cells;Neuroblastoma;novel therapeutics;Patients;Pre-Clinical Model;pre-clinical therapy;Process;Research Personnel;response;Structure;System;Transgenic Organisms;Translating;Translations;tumor;Work

PROJECT_TITLE: Development of new therapies for neuroblastoma


NIH_SPENDING_CATS: Cancer

PROJECT_TITLE: Eukaryotic Protein Maturation and Transport


PROJECT_TERMS: Binding;Biological Process;cellular engineering;Collaborations;Complex;Cryoelectron Microscopy;Disease;Health;Human;insight;Membrane;Microbiology;Molecular;Nature;novel;Nucleic Acid Folding;Outcome;pathogenic bacteria;Pharmaceutical Preparations;Proteins;Publications;Publishing;receptor;RNA;RNA Folding;Series;Signal Transduction;structural biology;Structure;Therapeutic;Virulence

PROJECT_TITLE: Structural biology collaborations


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine;Women's Health Research

PI_NAMEs: WEYEMI, SOSSOU  (contact)

PROJECT_TERMS: ADP ribosylation;Aging;Antineoplastic Agents;ataxia telangiectasia mutated protein;Biochemical;Bioenergetics;Breast Cancer Cell;cancer cell;cancer therapy;Cell Death;Cell Line;Cell model;Cell Survival;Cells;Cessation of life;Citric Acid Cycle;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR library;CRISPR/Cas technology;Cysteine;Data;desensitization;Disease;Disulfides;DNA Damage;DNA Repair;DNA Repair Gene;DNA Repair Inhibition;DNA Repair Pathway;Drug resistance;Fostering;Genes;Genetic;Genetic Screening;Genome;Genome Stability;Genomic Instability;Glycolysis;Goals;Homeostasis;homologous recombination;Human;Impairment;In Vitro;in vivo;inhibitor;Knock-out;Link;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;Mammalian Cell;Mediating;Metabolic;Metabolic Pathway;Metabolism;Mitochondria;Mus;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;PARP inhibition;Pathway interactions;Pentosephosphate Pathway;peroxiredoxin I;Pharmaceutical Preparations;Pharmacotherapy;Phosphotransferases;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;precision medicine;programs;Proteins;pyruvate carrier;repaired;Research;Resistance;Resistance development;resistance mechanism;Respiration;response;Ribosomal Proteins;Role;Signal Transduction;Stress;synergism;Testing;Therapeutic;therapy resistant;TP53 gene;triple-negative invasive breast carcinoma;tumor progression

PROJECT_TITLE: Dialogue between genomic instability and metabolism in diseases


PI_NAMEs: GLOD, JOHN  (contact)

PROJECT_TERMS: Adult;Age;alpha ketoglutarate;Cancer Patient;cancer type;Caring;Catecholamines;Cells;Child;Classification;cohort;Collection;Data;demethylation;Dioxygenases;Disease;DNA;Early Diagnosis;Enzyme Inhibition;Enzymes;Excision;Family;Fumarates;Gastrointestinal Stromal Tumors;Germ Lines;Goals;High-Risk Cancer;Hypermethylation;inhibitor;Localized Disease;Magnetic Resonance Imaging;Malignant Neoplasms;Metabolic;metabolic profile;metabolomics;Methods;Methylation;Modeling;Molecular;mutant;Mutation;Natural History;Paraganglioma;participant enrollment;patient population;patient screening;Patients;Pediatric Oncology;peripheral blood;Pheochromocytoma;predictive signature;profiles in patients;prospective test;rare cancer;Renal Cell Carcinoma;Reporting;Research;Sampling;screening;Screening for cancer;screening guidelines;Serum;Solid Neoplasm;Succinate Dehydrogenase;Succinates;Testing;Training;training data;tumor;tumor DNA;Urine

PROJECT_TITLE: Early Detection of Cancer Patients with Germline SDH Deficiency


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases;Sleep Research;Telehealth

PI_NAMEs: ARMSTRONG, TERRI S. (contact)

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affect;affective disturbance;Anxiety;anxiety states;Brain Neoplasms;Central Nervous System Neoplasms;Cessation of life;Circadian Dysregulation;Circadian Rhythms;Clinical Trials;Collection;computer generated;death anxiety;depressive symptoms;Diagnosis;diaries;Distress;Electronics;Emotional;emotional symptom;Environment;Equipment and supply inventories;experience;falls;Feeling;fitbit;Health;Health Technology;Heart Rate;Home;improved;indexing;Individual;Intervention;Learning;Measurement;Measures;Mental Depression;Mental disorders;Moods;National Comprehensive Cancer Network;Participant;participant enrollment;patient population;Patient Recruitments;Patient Self-Report;Patient-Focused Outcomes;Patients;Personal Satisfaction;Persons;Phase;physical symptom;Population;preference;Primary Brain Neoplasms;Questionnaires;Reporting;research clinical testing;Sleep;Sleep disturbances;sleep health;sleep quality;stress reduction;Surveys;Symptom Burden;Symptoms;Technology;telehealth;Thermometers;tumor;tumor diagnosis;virtual assessment;virtual reality;virtual reality headset;virtual reality intervention;wearable device

PROJECT_TITLE: Implementation of telehealth and health technology to improve patient outcomes


PI_NAMEs: PASTAN, IRA  (contact)

PROJECT_TERMS: Antibodies;Antibody Therapy;Antibody-drug conjugates;Binding;Bispecific Antibodies;Bite;Body Fluids;CAR T cell therapy;CD3 Antigens;Cell Line;Cell membrane;Cell Surface Proteins;Cells;chimeric antigen receptor T cells;Clinical Trials;Disease remission;Dose;FDA approved;Goals;Human;Immune;In complete remission;Malignant Neoplasms;Membrane;mesothelin;Mesothelioma;mouse model;Mus;neoplastic cell;novel;Peptide Hydrolases;recruit;response;T-Lymphocyte;targeted treatment;tumor

PROJECT_TITLE: CAR-T Therapy of Mesothelin Expressing Cancers


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Hematology;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

PI_NAMEs: HICKSTEIN, DENNIS  (contact)

PROJECT_TERMS: Acute;Age;Allogenic;Anemia;autoinflammatory;Blood Platelets;Bone Marrow;Bone Marrow Cells;Bone marrow failure;Busulfan;Cessation of life;Characteristics;Classification;Clinical;clinical phenotype;conditioning;Cutaneous;Cyclophosphamide;cytopenia;design;Development;Disease;Dose;Drug Kinetics;Dysmyelopoietic Syndromes;Dysplasia;Ear;Eligibility Determination;Engraftment;Enzymes;Erythroid Progenitor Cells;Fever;fludarabine;Genes;Genetic;Glucocorticoids;graft vs host disease;Hematologic Neoplasms;Hematology;Hematopoietic Stem Cell Transplantation;Infiltration;Inflammatory;inflammatory marker;Link;Lung;Marrow;Methionine;Morbidity - disease rate;mortality;Mosaicism;Musculoskeletal;Mutation;mycophenolate mofetil;Myelogenous;Myeloproliferative disease;Names;Neutropenia;Nose;novel;Participant;patient population;Patients;phase 2 study;Plasma Cell Neoplasm;Polyarteritis Nodosa;post-transplant;Prednisone;Prophylactic treatment;Recurrence;Refractory;Regimen;Relapsing polychondritis;Research;Research Personnel;Secondary to;Sirolimus;skin lesion;Somatic Mutation;Steroids;Sweet's Syndrome;Syndrome;systemic inflammatory response;Temporal Arteritis;Testing;Thrombocytopenia;Time;Transfusion;Ubiquitin-Activating Enzymes;United States National Institutes of Health;Vacuole;Whole-Body Irradiation

PROJECT_TITLE: Hematopoietic Stem Cell Transplant for VEXAS


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PI_NAMEs: MA, LICHUN  (contact)

PROJECT_TERMS: Biological Assay;cancer cell;Cancer Intervention;cancer therapy;Cells;Clinical;Detection;Early Diagnosis;Goals;Hepatology;Heterogeneity;Imaging technology;Immune;improved;indexing;liver cancer patient;Liver neoplasms;Malignant neoplasm of liver;Neoplasm Metastasis;neoplastic cell;novel strategies;Outcome;Patients;Publishing;Secondary to;Technology;Therapeutic;tumor;tumor heterogeneity;tumor-immune system interactions

PROJECT_TITLE: Tumor heterogeneity in liver cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

PROJECT_TERMS: Automobile Driving;cancer cell;Cancer Intervention;Cells;Classification;Evolution;Goals;Immunologic Surveillance;Immunotherapy;liver biopsy;liver cancer patient;Medicine;Molecular;patient prognosis;Patient-Focused Outcomes;Patients;Play;Publishing;Reporting;response;Role;transcriptomic profiling;Treatment Failure;treatment response;tumor;tumor heterogeneity;tumorigenesis

PROJECT_TITLE: Tumor evolution in response to treatment


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: MACHIDA, YUICHI  (contact)

PROJECT_TERMS: anti-cancer therapeutic;Architecture;Biochemical;cancer cell;Chemicals;crosslink;Data;Development;dimer;Dimerization;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;DNA-protein crosslink;Enzymes;Goals;Hydrophobic Interactions;improved;inhibitor;Interphase;Length;Molecular Sieve Chromatography;Movement;Mutation;Peptide Hydrolases;Pharmaceutical Preparations;Photometry;Protease Domain;Proteins;Recombinants;Regulation;Roentgen Rays;Serine Protease;Site;Structure;Therapeutic;Topoisomerase Inhibitors

PROJECT_TITLE: DNA Replication and Repair


PI_NAMEs: ELMLUND, HANS  (contact)

PROJECT_TERMS: Algorithm Design;Cells;computational platform;computerized tools;computing resources;Cryo-electron tomography;Cryoelectron Microscopy;Data;data acquisition;Data Analyses;Data Collection;data quality;Data Set;Electron Microscopy;experimental study;Feedback;Future;Goals;Image;Image Analysis;image processing;image reconstruction;imaging modality;improved;instrument;Liquid substance;Manuals;Methods;Microscope;movie;nanocrystal;particle;Preparation;Procedures;Research Personnel;Robotics;Sampling;statistics;Stream;success;Time;Tissues

PROJECT_TITLE: Unsupervised image processing methods for cryoEM analysis in real time


NIH_SPENDING_CATS: Bioengineering;Cancer;Nanotechnology

PROJECT_TITLE: Algorithms for atomic-resolution structure identification of nanocrystals


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Orphan Drug;Patient Safety;Rare Diseases;Skin Cancer

PI_NAMEs: SALOURA, VASSILIKI  (contact)

PROJECT_TERMS: Admission activity;Adverse event;Area;arm;Beds;cancer imaging;Chemotherapy and/or radiation;clinical center;Clinical Protocols;Clinical Trials;Confidence Intervals;Data;design;Diagnosis;Dose;efficacy evaluation;Eligibility Determination;Enrollment;Evaluation;Event;Excision;experience;Fluorescence;fluorescence imaging;follow-up;Frequencies;Giant Cells;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;histiocyte;Hour;Image;imaging system;indexing;individual patient;Inpatients;interstitial;Intravenous infusion procedures;Lasers;Length;Lesion;Light;Lighting;Measures;Medical;Medical Records;Neoadjuvant Therapy;open label;Operative Surgical Procedures;participant enrollment;Pathologic;Patients;Phase;phase 2 study;photoimmunotherapy;Phototherapy;Population;primary endpoint;Principal Investigator;Procedures;Progression-Free Survivals;Protocols documentation;Reaction;Real-Time Systems;Recurrence;Research Personnel;Resectable;Resected;response;Safety;safety assessment;Sampling;screening;Site;skin squamous cell carcinoma;standard of care;System;Telephone;Testing;Therapeutic Effect;Time;treatment duration;tumor;Tumor Cell Necrosis;United States National Institutes of Health;Visit

PROJECT_TITLE: Neoadjuvant Photoimmunotherapy in Head and Neck Cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Urologic Diseases

PI_NAMEs: BANDAY, ABDUL  (contact)

PROJECT_TERMS: Area;Automobile Driving;Bioinformatics;Biological;Bladder;Bladder Neoplasm;Cancer Biology;cancer cell;cancer risk;cancer therapy;cell transformation;Cells;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cofactor;Common Neoplasm;Deaminase;Dedications;Dependence;Development;Disease;DNA;DNA Sequence Alteration;driver mutation;druggable target;Enhancers;Enzymes;epithelial to mesenchymal transition;Evolution;Exhibits;functional genomics;Gene Expression;Genes;Genetic;genetic manipulation;genome wide association study;Germ-Line Mutation;Goals;Heterogeneity;immune cell infiltrate;Immunologic Surveillance;immunoregulation;improved;In Vitro;in vivo;Induced Mutation;Intrinsic factor;Knowledge;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Mediating;Molecular;Multiomic Data;multiple omics;Muscle;Mutagenesis;Mutate;Mutation;Natural Immunity;neoantigens;Neoplasm Metastasis;new therapeutic target;Nucleic Acids;Nucleotides;Oligonucleotides;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Phenotype;Play;prevent;Process;programs;promoter;Recurrence;Regulatory Element;Research;Resistance;response;RNA Splicing;Role;Somatic Mutation;Testing;Therapeutic;therapeutically effective;therapy resistant;Tissues;tool;Trans-Splicing;treatment response;tumor;tumor microenvironment;tumor progression;Tumor Subtype;tumorigenesis;tumorigenic;Untranslated RNA;Variant;Viral

PROJECT_TITLE: Investigating mechanisms of bladder tumorigenesis and therapeutic resistance


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Radiation Oncology;Rare Diseases

PI_NAMEs: KRAUZE, ANDRA  (contact)

PROJECT_TERMS: Address;Adjuvant;Agreement;American;Artificial Intelligence;Brain;Brain Neoplasms;Classification;Clinic;Clinical;cohort;cone-beam computed tomography;Data;Data Set;data sharing;Diagnosis;Diagnostic;Excision;federated learning;follow-up;Glioblastoma;Glioma;Image;Immunotherapy;improved outcome;In complete remission;Linear Accelerator Radiotherapy Systems;Link;Magnetic Resonance Imaging;Managed Care;Medicine;Methylation;MGMT gene;Molecular;neuro-oncology;Neurologic;novel;Operative Surgical Procedures;partial response;Patient-Focused Outcomes;Patients;Postoperative Period;Progression-Free Survivals;Publishing;Radiation;Radiation therapy;response;Scanning;Selection for Treatments;Stable Disease;standard of care;Steroids;temozolomide;Time;Toxic effect;Treatment Efficacy;treatment optimization;tumor;tumor progression;Work

PROJECT_TITLE: Using artificial intelligence and MRI to address limitations in glioblastoma


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

PROJECT_TERMS: Adjuvant;Agreement;Algorithms;Biological Markers;biomarker discovery;Brain;Brain Neoplasms;Classification;Clinic;Clinical;clinical application;clinical predictors;clinically relevant;cohort;Data;Data Set;Dose;Early treatment;Eligibility Determination;Excision;follow-up;Fostering;Fractionation;Glioblastoma;Glioma;Histone Deacetylase Inhibitor;Image;Immunotherapy;improved;irradiation;Magnetic Resonance Imaging;Managed Care;metabolomics;Neurologic;Operative Surgical Procedures;Pathway interactions;Patients;Pharmaceutical Preparations;predictive signature;prognostic;prognostic signature;proteogenomics;Proteome;Proteomics;Publishing;Radiation therapy;radiological imaging;response;Serum;standard of care;Steroids;Systemic Therapy;temozolomide;Time;Treatment Failure;tumor;Valproic Acid;Visit;Work

PROJECT_TITLE: Proteogenomic characterization and biomarker discovery in glioblastoma


NIH_SPENDING_CATS: Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Radiation Oncology;Rare Diseases

PROJECT_TERMS: Adjuvant;Agreement;Artificial Intelligence;Bioinformatics;Biological;Biological Markers;biomarker discovery;Brain;Brain Neoplasms;Classification;Clinic;Clinical;clinical application;Clinical Data;clinical predictors;Collaborations;Computational Biology;Data;Diagnosis;Diagnostic;disease natural history;Dose;Excision;follow-up;Fractionation;Genomics;Glioblastoma;Glioma;Image;Immunotherapy;improved;improved outcome;lens;Link;Magnetic Resonance Imaging;Managed Care;Measures;metabolomics;Methodology;neuro-oncology;Neurologic;novel;Operative Surgical Procedures;Patient-Focused Outcomes;Patients;Pattern;predictive signature;prognostic;prognostic signature;Progression-Free Survivals;Proteomics;Protocols documentation;Publishing;Radiation therapy;response;Serum;Signal Transduction;Staging;standard of care;Steroids;Stratification;Systemic Therapy;Systems Biology;temozolomide;Time;tumor;tumor progression;Tumor Volume;Valproic Acid;Work

PROJECT_TITLE: Prognostic and predictive clinical and proteomic biomarker discovery in GBM


NIH_SPENDING_CATS: Cancer;Clinical Research;Data Science;Networking and Information Technology R&D (NITRD);Radiation Oncology

PROJECT_TERMS: Aftercare;Artificial Intelligence;Biological Markers;Clinical Data;Computer Analysis;Data;Data Aggregation;Data Analyses;data framework;data streams;Dose;Ensure;Genomics;Goals;Image;Laboratories;large scale data;Maintenance;Malignant Neoplasms;Organ;Pathology;Pattern;Process;Proteomics;Radiation;Radiation therapy;Resistance;response;Risk;Span 20;Structure;Surface;System;Testing;Time;Tissues;treatment planning;United States National Institutes of Health

PROJECT_TITLE: Generating a multi-channel data framework for AI analysis in Radiation therapy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Comparative Effectiveness Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PROJECT_TERMS: Address;Algorithms;artificial intelligence algorithm;artificial intelligence model;Behavior;Biological;Biological Markers;Blood;cancer stem cell;Clinical;Clinical Data;Complex;Data;data cleaning;Data Collection;data harmonization;Data Set;data-driven model;design;Evaluation;Excision;Failure;feature selection;Glioblastoma;Histology;improved;improved outcome;Infrastructure;irradiation;Link;Location;Measures;Methods;Methylation;MGMT gene;Molecular;multidimensional data;Normal tissue morphology;novel;Oncology;Outcome;Patient imaging;Patient-Focused Outcomes;Patients;Performance;Printing;prognostic;protein expression;Proteomics;Publications;Publishing;Radiation therapy;Radiometry;Serum;Serum Proteins;Signal Pathway;Signal Transduction;Site;standard of care;stem cells;Testing;Time;tissue biomarkers;treatment optimization;tumor;Tumor Tissue;United States National Institutes of Health;Urine;Validation;Work

PROJECT_TITLE: Advancing clinically meaningful AI algorithms to improve oncologic outcomes


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

PI_NAMEs: JOHNSON, PETER F (contact)

PROJECT_TERMS: 3' Untranslated Regions;Adenocarcinoma;adenoma;Affinity Chromatography;Animals;Antineoplastic Agents;Area;Benign;Binding;Binding Proteins;Binding Sites;Biogenesis;BRAF gene;Bypass;cancer cell;Cancer cell line;Cell Senescence Induction;Cells;Complex;Cytoplasm;Cytostatics;Dependence;Development;disabled;Disease;DNA Damage;drug discovery;Elements;Endosomes;Exclusion;factor C;Fibroblasts;Future;Gene Expression;Genes;Goals;IL6 gene;in vivo;in vivo evaluation;Individual;Inflammatory;interest;Investigation;Knockout Mice;KRAS2 gene;KRASG12D;KSR gene;Laboratories;Lung Neoplasms;lung tumorigenesis;Malignant - descriptor;Malignant Neoplasms;MAPK1 gene;MAPK3 gene;MDM2 gene;Messenger RNA;Modeling;Modification;Molecular;Molecular and Cellular Biology;mRNA Decay;Mus;Mutate;neoplastic cell;Normal Cell;novel anticancer drug;Nuclear;Nuclear Decay;Nuclear Translocation;Oncogenes;Oncogenic;Oncoproteins;Pathway interactions;phosphoproteomics;Phosphorylation;Phosphorylation Inhibition;Phosphotransferases;Play;Population;Post-Translational Protein Processing;prevent;Probability;programs;Proliferating;protein degradation;Proteins;PTEN gene;RAS genes;RAS inhibition;ras Oncogene;recruit;Regulation;Repression;Research;restraint;Ribosomes;RNA Decay;Role;scaffold;senescence;senescence associated secretory phenotype;Signal Transduction;Site;small molecule inhibitor;therapeutic DNA;Tissues;TOLLIP gene;TP53 gene;Transcript;transcription factor;Translating;Translational Activation;Translations;tumor;Tumor Cell Line;Tumor Suppression;Tumor Suppressor Proteins;ubiquitin ligase

PROJECT_TITLE: Control of Oncogenic Signaling Through Spatial Organization of Kinases and mRNAs


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

PI_NAMEs: AREGGER, MICHAEL  (contact)

PROJECT_TERMS: Cell Line;Cells;Chromosome Mapping;combinatorial;Data Analyses;Dependence;fitness;follow-up;functional genomics;Genes;Genetic;genome-wide;Goals;insight;knockout gene;Libraries;Malignant Epithelial Cell;Metabolic;novel;nuclease;Patients;Regulation;Renal Cell Carcinoma;screening;System;Therapeutic;Translations;Validation;Western Blotting

PROJECT_TITLE: Interrogating genetic interactions  dependencies in renal cell carcinoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PROJECT_TERMS: Cell Line;Cell surface;cell type;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;DNA Damage;expression vector;Flow Cytometry;Gene Expression;Gene Targeting;Genes;Genetic Transcription;Individual;knockout gene;Malignant Neoplasms;nuclease;Pathway interactions;promoter;recruit;Repression;response;screening;System;Tissues;Transcription Coactivator;Transcription Repressor;Variant;Western Blotting;Work

PROJECT_TITLE: Combinatorial CRISPR transcriptional perturbation screening platform


PROJECT_TERMS: Ablation;Binding Sites;Biological Process;Biomedical Research;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combinatorial;cost;cost effective;Coupled;CRISPR screen;Data;design;Disease;DNA cassette;experimental study;expression vector;gene function;Genes;Genetic;genetic element;Genetic Screening;genome-wide;genomic platform;Genomics;Guide RNA;Hybrids;indexing;insight;Libraries;Link;loss of function;novel;Phenotype;prevent;Process;Proteins;Protocols documentation;Reagent;response;Role;screening;single cell analysis;single-cell RNA sequencing;Technology;therapeutic candidate;Therapeutic Intervention;transcriptome;transcriptomics

PROJECT_TITLE: Establishing combinatorial screening platform coupled to single-cell analysis


PROJECT_TERMS: Algorithm Design;Cancer cell line;Cell Line;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;combinatorial;Data;Databases;design;Exons;experimental study;fitness;Genes;Genetic;genetic element;Genetic Screening;genome editing;genome-wide;Genomics;Guide RNA;Human Genome;Hybrids;improved;Individual;knockout gene;Libraries;Maps;Modification;mouse genome;nuclease;online resource;paralogous gene;promoter;Property;Resources;scaffold;screening;searchable database;Signal Transduction;Site;System;Testing;Time;tool;Variant;Work

PROJECT_TITLE: Improving editing efficiency and guide design of CHyMErA screening platform


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Cervical Cancer;Genetics;Human Genome;Infectious Diseases;Nanotechnology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Sexually Transmitted Infections;Skin Cancer;Women's Health Research

PI_NAMEs: KOLMOGOROV, MIKHAIL  (contact)

PROJECT_TERMS: 11q;African American Women;African ancestry;Age;BIRC2 gene;BIRC3 gene;Cancer cell line;Cancer Etiology;cancer type;Canis familiaris;Cell Line;Cervical;Cessation of life;Chromosomal Insertion;Chromosomal Rearrangement;Chromosome abnormality;chromothripsis;clinical application;Collaborations;Complex;Country;Diagnosis;Diagnostic;Dicentric chromosome;Digestion;DNA;DNA sequencing;driver mutation;Event;Evolution;Exonuclease;Genomics;Goals;Head and Neck Cancer;Human papilloma virus infection;Human Papillomavirus;Individual;insight;integration site;Karyotype;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Melanoma;Methods;Missouri;Modeling;multiple omics;Mus;nanopore;Osteosarcoma;Pattern;Pediatric Neoplasm;Prevalence;Research;Resources;Role;Site;targeted treatment;telomere;transcriptome sequencing;tumor;Variant

PROJECT_TITLE: The role of structural variation in promotion, evolution and treatment of various tumor types


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related;Women's Health Research

PI_NAMEs: FELBER, BARBARA K (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;adaptive immunity;Affect;Agonist;anti-PD-1;Apical;Area;B-Lymphocytes;Biology;Blood;Bone Marrow;Breast Cancer Cell;Breast Cancer Model;cancer immunotherapy;Cancer Model;Cancer Patient;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Characteristics;chemokine;Clinical;clinical application;Clinical Trials;Collaborations;collaboratory;combinatorial;Combined Modality Therapy;CXCL13 gene;cytokine;cytotoxic;cytotoxic CD8 T cells;Data;Dendritic Cells;design;Development;Disease;Disseminated Malignant Neoplasm;DNA Vaccines;Dose;Effector Cell;EO771;Evaluation;Exclusion;exhaustion;experimental study;Extramural Activities;Family;Fatty Acids;Fenofibrate;first-in-human;FLT3 ligand;Frequencies;Gene Expression;Gene Expression Profile;gene therapy;genetic signature;glycosylation;Goals;Growth Factor;HIV;HIV Infections;HIV therapy;IL7 gene;Immune;Immune response;Immune system;Immunity;Immunologic Memory;immunological intervention;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;inhibitor;interest;Interferons;Interleukin-15;interleukin-21;Intervention;ITGAM gene;Link;Location;lymph nodes;Lymphocyte;Lymphocyte Activation;Lymphocyte Function;Lymphocytic Infiltrate;Lymphoid;Lymphoid Cell;Lymphopoiesis;Macaca;Macaca mulatta;Maintenance;Malignant Neoplasms;Mediating;Metabolic;metabolic fitness;Metabolism;Methods;migration;Mitochondria;Modeling;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;National Institute of Allergy and Infectious Disease;Natural Killer Cells;Neoplasm Metastasis;orthotopic breast cancer;Oxygen Consumption;Pathway interactions;Phenotype;Plasma;Play;Population;PPAR alpha;pre-clinical;prevent;Production;Proliferating;Property;Proteomics;Protocols documentation;recruit;Regimen;Regulation;Regulatory T-Lymphocyte;Reporting;Research Personnel;response;Role;Shapes;simian human immunodeficiency virus;Site;SIV;SIV Vaccines;Structure of germinal center of lymph node;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;transcriptomics;Treatment Efficacy;Treatment Protocols;triple-negative invasive breast carcinoma;tumor;tumor eradication;tumor growth;tumor microenvironment;Up-Regulation;uptake;vaccine strategy;Viral;Viral reservoir;viral RNA;Viremia;Virus;Work

PROJECT_TITLE: Examining IL-15 and IL-7 as an immunotherapy agent in cancer and AIDS


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Neurodegenerative;Neurosciences;Orphan Drug;Patient Safety;Peripheral Neuropathy;Rare Diseases

PI_NAMEs: RAJAN, ARUN  (contact)

PROJECT_TERMS: Adverse event;Amendment;arm;Biogenesis;chemotherapy;Clinical;design;Development;Disease;Disease Progression;DNA Repair Pathway;Dose;Enrollment;experience;Frequencies;immunogenic cell death;inhibitor;intravenous administration;Molecular;Nausea;Neutropenia;novel therapeutics;objective response rate;partial response;Participant;Patients;Peripheral Nervous System Diseases;Pharmacotherapy;phase I trial;phase II trial;Platinum;Progression-Free Survivals;Progressive Disease;Property;Protocols documentation;Recurrence;Recurrent disease;Refractory;Relapse;Resistance;response;Ribosomes;Safety;Schedule;standard of care;Thrombocytopenia;Thymic Carcinoma;Thymoma;Thymus Epithelial Neoplasm;tumor;Unresectable

PROJECT_TITLE: A Phase II Trial of PT-112 in Subjects with Thymoma and Thymic Carcinoma


NIH_SPENDING_CATS: Cancer

PI_NAMEs: JONES, JENNIFER  (contact)

PROJECT_TITLE: Classification and Ontology of Macromolecular Complexes in Liquid Biopsies


NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Pediatric Cancer;Rare Diseases

PROJECT_TERMS: Address;Algorithms;Aneuploidy;Basic Science;Benchmarking;cancer genome;cancer genomics;Cell Line;Clinical;Clinical Research;clinically relevant;Clonality;Collaborations;Communities;Complex;Copy Number Polymorphism;Data;Data Set;Detection;detection method;Development;DNA Sequencing Facility;Extramural Activities;Genetic;Genomics;Graph;Malignant Childhood Neoplasm;Malignant Neoplasms;Methods;nanopore;Normal Cell;open source tool;Phase;reconstruction;Research Personnel;Sampling;sequencing platform;tool;tumor;Variant;variant detection

PROJECT_TITLE: New algorithms for long-read cancer genomics


PROJECT_TERMS: Algorithms;Bacteria;Brain;Collaborations;Complex;Computer software;cost;Data;Dryness;Genetic Recombination;gut microbiome;Human;Human Genome;Human Microbiome;metagenomic sequencing;Methylation;nanopore;Population;Sampling;Technology;United States National Institutes of Health;Variant

PROJECT_TITLE: Population-scale, long-read characterization of human genome and microbiome


NIH_SPENDING_CATS: Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

PI_NAMEs: BOXER, LISA  (contact)

PROJECT_TERMS: Affect;Binding Proteins;Brain;Cell division;cell type;Chromatin;Development;Disease;DNA;DNA Binding;DNA Damage;DNA Methylation;DNA Sequence;Epigenetic Process;experimental study;Face;Genes;Genetic Transcription;Genome;genome integrity;Genomic approach;Goals;histone modification;Hour;Impairment;insight;Lead;Learning;life span;loss of function mutation;Malignant Neoplasms;Memory;Methyl-CpG-Binding Protein 2;Methylation;Modification;Molecular;Mus;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic;Neurons;Organism;overexpression;postnatal;protein degradation;Proteins;Reader;Regulation;Research;Research Project Grants;Rett Syndrome;Role;Syndrome;transcriptome sequencing

PROJECT_TITLE: Chromatin Regulation in Brain Development and Disease


PI_NAMEs: KELLY, KATHLEEN  (contact)

PROJECT_TERMS: Address;Adenocarcinoma;advanced prostate cancer;Androgen Receptor;Androgens;Animal Model;Biology;Bone Tissue;Cell Survival;Clinical;clinical phenotype;Communities;deprivation;Development;experience;Goals;Growth;Human;in vivo;Incidence;inhibitor;Investigation;Malignant neoplasm of prostate;Metastatic Neoplasm to the Bone;metastatic process;Modeling;Neoplasm Metastasis;novel therapeutic intervention;Organoids;patient derived xenograft model;Patients;Phenotype;Physiology;prostate cancer metastasis;Publishing;RB1 gene;Receptor Signaling;Recovery;Reproducibility;Resistance;Role;soft tissue;Technology;Time;TP53 gene;treatment response;tumor;tumor heterogeneity

PROJECT_TITLE: Biology of AR+ prostate cancer metastases and the role of the microenvironment


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

PI_NAMEs: RAJAGOPAL, PADMA  (contact)

PROJECT_TERMS: Age;Area;Atlases;Breast Cancer Treatment;cancer genomics;cancer subtypes;cancer therapy;Categories;Clinical;Clinical Treatment;cloud based;Cohort Analysis;Consensus;Data;Data Analyses;data integration;Data Set;Diagnosis;Disease;Distant Metastasis;DNA;exome sequencing;Generations;genetic variant;Germ Lines;Germ-Line Mutation;Heterogeneity;human data;improved;Infrastructure;Linear Regressions;Literature;Logistic Regressions;Malignant Breast Neoplasm;Malignant Neoplasms;Meta-Analysis;Metastatic breast cancer;multiple omics;Outcome;Participant;Patients;Pharmaceutical Preparations;programs;Publications;Publishing;Race;Reporting;response;Sampling;Somatic Mutation;standard of care;systematic review;Testing;The Cancer Genome Atlas;Time;treatment response;tumor;United States National Institutes of Health;Update;Validation;validation studies;Variant

PROJECT_TITLE: Germline-Somatic Interactions and Association with Treatment Response in Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cancer;Emerging Infectious Diseases;Infectious Diseases;Microbiome

PI_NAMEs: O'REILLY, FRANCIS  (contact)

PROJECT_TERMS: Address;Amino Acids;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Cancer Patient;Cells;Code;commensal bacteria;crosslink;Data;Diazomethane;Disease;DNA sequencing;DNA-Directed RNA Polymerase;Fractionation;Genes;Goals;gut bacteria;gut microbiota;Health;Hospitalization;Human;Leucine;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Metabolic;microbiome;Modeling;Molecular;novel;pathogen;pathogenic bacteria;protein complex;protein structure prediction;Protein-Protein Interaction Map;Proteins;Proteome;Reporting;Resolution;RNA;Salmonella;Salmonella enterica;Sepsis;Site;technology development;Ultraviolet Rays

PROJECT_TITLE: Discovery of novel protein complexes across human gut bacteria


NIH_SPENDING_CATS: Biotechnology;Cancer

PROJECT_TERMS: Address;Binding Sites;Cell Nucleus;Cells;Cellular Stress;Complex;crosslink;Cryoelectron Microscopy;Data;Disease;Eukaryota;Eukaryotic Cell;Frustration;Genetic;Home;Human;In Situ;information processing;interest;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Membrane;multicatalytic endopeptidase complex;Oncoproteins;Phase;Process;protein complex;protein protein interaction;protein purification;Proteins;Proteome;Proteomics;Research;stable cell line;structural biology;Structure;Techniques;Technology;Therapeutic;Work

PROJECT_TITLE: The topology of protein-protein interactions in situ in eukaryotic cells


PI_NAMEs: LEKO, VID  (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;Adoptive Cell Transfers;Adoptive Transfer;Blood;Bone Marrow;cancer immunotherapy;Cells;Characteristics;Clinical Protocols;cohort;Development;Dysmyelopoietic Syndromes;Goals;Hematologic Neoplasms;Hematology;In Vitro;Malignant Neoplasms;Mutation;Myelogenous;Myeloproliferative disease;neoantigens;next generation sequencing;Patient Transfer;Patients;Peptides;Peripheral Blood Mononuclear Cell;Prevalence;Research Project Grants;Solid;T cell response;T-Cell Receptor;T-Lymphocyte;translational goal;tumor;Validation

PROJECT_TITLE: Targeting cancer neoantigens in patients with myeloid malignancies


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: PRATT, DREW  (contact)

PROJECT_TERMS: Awareness;Bioinformatics;bioinformatics pipeline;Body System;cancer classification;Central Nervous System Neoplasms;Chromatin;Classification;Classification Scheme;Clinical;Communities;Complement;Consensus;Data;deep learning;density;Development;Diagnostic;DNA Methylation;Factor Analysis;Gene Expression;Genetic Transcription;Goals;Hi-C;improved;L1 Elements;Laboratories;Link;Machine Learning;machine learning classifier;Malignant Neoplasms;Medical;Methodology;Methylation;multiple omics;Mutation;novel;Organ;Pathology;Pathway interactions;personalized diagnostics;precision medicine;Repetitive Sequence;Research;Signal Transduction;Source;Techniques;transcriptome sequencing;tumor;United States National Institutes of Health

PROJECT_TITLE: DNA methylation-based machine classification of cancer


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Prostate Cancer;Urologic Diseases

PI_NAMEs: MADAN, RAVI  (contact)

PROJECT_TERMS: androgen independent prostate cancer;Artificial Intelligence platform;Biochemical;Biological Markers;Cancer Patient;Castrate sensitive prostate cancer;Clinical Trials;Data;Development;Disease Progression;FOLH1 gene;Goals;Image;Malignant neoplasm of prostate;Monitor;Natural History;Patients;Positron-Emission Tomography;prospective;Recurrence;Resources;Role;Scanning;Therapeutic Intervention;Time

PROJECT_TITLE: Defining Roles for PSMA PET Imaging in Prostate Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: DAVIES, ERIN  (contact)

PROJECT_TERMS: Adult;Amputation;Anatomy;Anterior;Apical;Atlases;Biological Markers;Cells;Collaborations;Data;Development;Embryonic Development;Female;Genetic;Germ Cells;germline stem cells;Gonadal structure;Homeostasis;Homologous Gene;Imaging Techniques;male;marine;Microscopy;Molecular;Morphogenesis;nano;Natural regeneration;Organ;Platyhelminths;Postembryonic;postnatal;Process;programs;Protocols documentation;Reaction;reconstruction;Regulation;reproductive;Reproductive system;Resources;Sampling;segregation;self assembly;self organization;sexual dimorphism;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;stem cells;Structure;Testis;Tissues;Transgenic Organisms;Visualization

PROJECT_TITLE: Inductive germ cell specification and self-assembly of sexually dimorphic gonads


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

PROJECT_TERMS: Adult;Anatomy;Atlases;Benchmarking;Bioinformatics;Biological Assay;Cancer Biology;cell behavior;Cell Lineage;Cell Ontogeny;Cell Transplantation;Cells;Collaborations;comparative;Coupling;Data;Development;Developmental Biology;Embryo;Embryonic Development;experimental study;Gene Expression;Goals;Homeostasis;in silico;Individual;innovation;irradiation;Laboratories;Life Cycle Stages;Maps;Mediating;Molecular;Natural regeneration;Organism;Planarians;Platyhelminths;pluripotency;Pluripotent Stem Cells;Population;postnatal;programs;Property;Quality Control;regenerative;Regulation;Sampling;Scientist;single-cell RNA sequencing;Source;Specific qualifier value;System;Time;Tissues;transcriptome;transcriptomics

PROJECT_TITLE: Embryonic origin of adult pluripotent stem cells and anatomical systems during planarian embryogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

PI_NAMEs: KLEMEN, NICHOLAS  (contact)

PROJECT_TERMS: Adoptive Cell Transfers;Affect;Aftercare;Biological Assay;Cancer cell line;CD28 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Therapy;Cells;Clinical Trials;comparative efficacy;cost;cytokine;Data;Flow Cytometry;Gene Expression;Gene Proteins;Genes;Genetic;genetic approach;Growth;HLA-A11;Human;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;Implant;improved;In Vitro;in vitro testing;in vivo;Infiltration;Injections;Interleukin-2;knock-down;KRAS2 gene;KRASG12D;MAP Kinase Gene;Modeling;Modification;Muromonab-CD3;Mus;Mutation;neoplastic cell;Oncogenic;Operative Surgical Procedures;overexpression;OX40;Pancreas;pancreatic cancer cells;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;pharmacologic;PIK3CG gene;Production;programmed cell death protein 1;Proliferating;Property;protein transport;PTEN gene;receptor;Role;Sampling;small hairpin RNA;small molecule inhibitor;Stains;subcutaneous;T cell differentiation;T cell therapy;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Testing;TNFRSF5 gene;TNFSF5 gene;Transcript;transport inhibitor;tumor;vector;Vertebral column;Viral Vector;Western Blotting

PROJECT_TITLE: Retroviral genetic modification of PBLs to optimize expansion for cell therapy


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: NG, SAMUEL  (contact)

PROJECT_TERMS: addiction;Affect;Animal Model;ATAC-seq;Autologous;Basic Science;Binding;Biopsy Specimen;Breeding;cancer cell;Cancer Model;CC chemokine receptor 4;Cell Line;Cells;Chemicals;chimeric antigen receptor T cells;Clinical;clinical application;clinical development;clinical trial protocol;Clinical Trials;Collaborations;Complex;CRISPR screen;Data;Disease;Drug Screening;Elements;Ensure;Epigenetic Process;experimental study;first-in-human;fitness;Gene Expression;Generations;Genetic;Genetic Predisposition to Disease;Genetic Screening;Genetically Engineered Mouse;Germ Lines;Goals;Guanine;Guanine Nucleotide Exchange Factors;human study;Immunoblastic Lymphadenopathy;Immunotherapy;Impairment;implantation;Inferior;Infrastructure;insight;intravenous injection;Kinetics;loss of function;loss of function mutation;Lymphoma cell;Lymphomagenesis;Malignant - descriptor;Malignant Neoplasms;Modeling;Molecular;Mus;Mutation;Non-Hodgkin's Lymphoma;Non-Malignant;novel;novel therapeutics;Outcome;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Peripheral;personalized immunotherapy;Pharmaceutical Preparations;phase I trial;Polycomb;Pre-Clinical Model;precision medicine;programs;Proteins;Protocols documentation;Research;rho;RHOA gene;Sampling;Sampling Studies;Signal Transduction;System;T-Cell Lymphoma;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Toxic effect;transcription factor;transcriptomics;translational study;whole genome;Work

PROJECT_TITLE: Targeting exploitable vulnerabilities in T-cell Lymphoma


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: GULLEY, JAMES L. (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;Alternative Splicing;Antibody-drug conjugates;Antigens;Award;B-Cell Acute Lymphoblastic Leukemia;B-Lymphocytes;Back;Bone Tissue;Brain Neoplasms;Cancer cell line;Cancer Patient;CCR;CD19 gene;CD22 gene;Cell Line;chemotherapy;Childhood;Childhood Leukemia;childhood sarcoma;chimeric antigen receptor T cells;Clinical Trials;Data;early phase clinical trial;effective therapy;Encyclopedias;Evaluation;Exons;Experimental Models;experimental study;Extramural Activities;FDA approved;first-in-human;Gene Modified;Goals;Hematologic Neoplasms;high throughput analysis;Human;Immune;Immune Targeting;Immunooncology;Immunotherapeutic agent;Immunotherapy;imprint;improved;improved outcome;Laboratories;Libraries;Lymphoid Cell;Malignant Childhood Neoplasm;Malignant Neoplasms;manufacture;Mediating;Messenger RNA;Methodology;Natural Killer Cells;Neuroblastoma;Neuroendocrine Tumors;Neurosecretory Systems;NK cell therapy;novel;novel therapeutic intervention;Open Reading Frames;Operative Surgical Procedures;participant enrollment;patient prognosis;Patient-Focused Outcomes;Patients;PAX5 gene;Pediatric Hospitals;phase I trial;Population Heterogeneity;Pre-Clinical Model;prevent;Procedures;Process;protein expression;Recurrence;Refractory Disease;Relapse;Research;Resistance;Resistance development;response;RNA Splicing;RNA-Binding Proteins;Role;Sampling;Site;Soft tissue sarcoma;Solid Neoplasm;Source;T-Lymphocyte;Testing;Transcript;transcription factor;Transforming Growth Factor beta;Translating;Translational Research;tumor;Tumor Immunity;tumor microenvironment;Untranslated RNA;vaccine development;Variant;vector;Work;young adult

PROJECT_TITLE: Bench to Beside and Back translational immuno-onocology-Cures


NIH_SPENDING_CATS: Brain Disorders;Breast Cancer;Cancer;Cardiovascular;Cerebrovascular;Hematology;Neurosciences;Stroke;Women's Health Research

PI_NAMEs: FUJII, TAKEO  (contact)

PROJECT_TERMS: 4T1;Acceleration;Age;Animal Model;anti-cancer;Anticoagulants;Area;Astrocytes;blood-brain barrier disruption;Bone Marrow;Brain;Brain Ischemia;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;Breast Cancer Treatment;C57BL/6 Mouse;cancer cell;Cancer Patient;Carotid Arteries;Cell Adhesion Molecules;Cells;chemokine;Circulation;Clinical;Clinical Research;Collaborations;Complete Blood Count;Control Groups;cytokine;Data;Deep Vein Thrombosis;Disease;Distant;Endothelial Cells;Environment;eosinophil;ERBB2 gene;Exhibits;Fatty acid glycerol esters;Female;Flow Cytometry;General Population;Goals;Growth;Hemorrhage;high risk;Immune;immune cell infiltrate;Immunocompetent;Immunofluorescence Immunologic;improved;Inbred BALB C Mice;Incidence;Inferior vena cava structure;Infiltration;Inflammation;Inflammatory;Injections;interest;Ischemia;Ischemic Stroke;Laboratory Study;Link;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant Neoplasms;mammary;Metastatic malignant neoplasm to brain;Microglia;Microspheres;Modeling;monocyte;mouse model;Mus;Myeloid Cells;Myocardial Infarction;National Heart, Lung, and Blood Institute;Neoplasm Metastasis;neutrophil;novel;novel strategies;novel therapeutic intervention;Operative Surgical Procedures;Organ;Patients;Pericytes;Phase;Phenotype;Prognosis;PTPRC gene;Reporting;Research;Risk;RNA Sequences;Role;sham surgery;Stains;survival outcome;systemic inflammatory response;Testing;Therapeutic Intervention;Thrombocytopenia;thromboembolic stroke;Thromboembolism;Thrombosis;thrombotic complications;Time;trend;triple-negative invasive breast carcinoma;tumor;tumor microenvironment;tumor progression;Up-Regulation;venous thromboembolism

PROJECT_TITLE: Elucidating the role of thrombosis and inflammation in breast cancer metastasis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Rare Diseases;Sexually Transmitted Infections;Vaccine Related

PI_NAMEs: ALLEN, CLINT  (contact)

PROJECT_TERMS: Acceleration;Address;Adoptive Transfer;Aftercare;Alcohol abuse;anti-tumor immune response;Antigens;Autologous;Basic Science;Biopsy Specimen;Blood specimen;Cell surface;Cells;chimeric antigen receptor T cells;Chronic;chronic infection;Circulation;Clinical;clinical center;Clinical Research;confirmatory clinical trial;Correlative Study;Data;design;Development;Disease;early phase clinical trial;engineered T cells;Epithelial Neoplasms;Excision;Gene Expression;Goals;Head and Neck Neoplasms;Head and Neck Squamous Cell Carcinoma;Head and neck structure;Human papilloma virus infection;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 11;Human papillomavirus 6;immune checkpoint blockade;Immunity;Immunotherapy;improved;In complete remission;industry partner;Infiltration;Laboratories;Life;Medical;Mus;Neoadjuvant Study;Neoadjuvant Therapy;Neoplasms;neoplastic cell;Newly Diagnosed;novel;novel strategies;novel therapeutics;novel vaccines;Operative Surgical Procedures;Papilloma;Papillomatoses;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Phase;phase 2 study;pre-clinical;programs;Protocols documentation;Recurrent respiratory papillomatosis;Repeat Surgery;Research;Residencies;respiratory;Shapes;Specimen;standard of care;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapeutic;therapeutic evaluation;therapeutic vaccine;Tissues;tobacco abuse;Transforming Growth Factor beta;Translating;trial planning;tumor;Tumor Debulking;Tumor Immunity;United States National Institutes of Health;Vaccination;vaccination outcome;Vaccine Design;Vaccine Therapy;Voice;Work

PROJECT_TITLE: Enhancing anti-tumor immunity in head and neck neoplasms


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: MUTHUSWAMY, SENTHIL  (contact)

PROJECT_TERMS: anti-cancer research;Autologous;Biotin;Biotinylation;Cell Line;Cell Polarity;Cell surface;Cell Surface Proteins;Cells;Clonal Evolution;Coculture Techniques;Complement;Drug resistance;gemcitabine;Gene Expression;Genetic Screening;Immune Evasion;Investigation;Knock-out;Label;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Modeling;Organoids;overexpression;Patients;peripheral blood;Pharmaceutical Preparations;Process;process optimization;Proteins;Resistance;Signal Transduction;T-Cell Receptor;T-Lymphocyte;Techniques;Therapeutic;tumor

PROJECT_TITLE: Tumor organoids and cell polarity: models and mechanisms for cancer research


NIH_SPENDING_CATS: Cancer;Genetics

PI_NAMEs: KOIVOMAGI, MARDO  (contact)

PROJECT_TERMS: Active Sites;Affect;Aging;Alleles;alpha helix;analog;Antibodies;Attention;Binding;Biochemical;Bioinformatics;Biological Assay;C-terminal;cancer cell;candidate identification;Cell Cycle;Cell Cycle Inhibition;Cell Cycle Progression;Cell Differentiation process;Cell division;cell growth;Cell Line;Cell Proliferation;Cells;Chemical Engineering;Complex;Coupled;Cyclin D1;cyclin G1;Cyclin Regulation of Cell Cycle Pathway;Cyclin-Dependent Kinases;Cyclins;DNA;Docking;Engineering;Ensure;Equipment;experimental study;Family;Family member;G1 Arrest;G1/S Transition;Gene Expression;Genetic Screening;Genetic Transcription;Human;Imaging Techniques;improved;In Vitro;in vivo;inhibitor;Kinetics;Label;Laboratories;Link;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;Metabolism;Methods;Modeling;Modification;Molecular;Mutation;Normal Cell;novel;Peptides;Phase;Phase Transition;phosphoproteomics;Phosphorylation;Phosphotransferases;Play;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Preparation;prevent;Process;promoter;Protein C;protein protein interaction;Proteins;Proteome;Proteomics;Reagent;reconstitution;recruit;Regulation;Research;Resources;Retinoblastoma Protein;RNA Polymerase II;Role;Rotation;S phase;Saccharomycetales;Scientist;Side;Site;small molecule;Students;summer student;System;Techniques;Testing;Time;tool;Transcriptional Activation;transcriptomics;tumor;Visit;volunteer;Work;Yeasts

PROJECT_TITLE: Biochemical mechanisms cyclin-dependent kinases use to control cell division


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: PENAS-PRADO, MARTA  (contact)

PROJECT_TERMS: Adult;Area;Biology;Caring;Central Nervous System Neoplasms;Clinical;clinical care;Clinical Data;Clinical Trials;cohort;Collaborations;Data;Databases;Development;Disease;disorder control;DNA Repair;Education;efficacy testing;Enrollment;Ependymoma;Face;follow-up;Geographic Locations;Goals;Immunotherapy;Information Technology;Institution;Institutional Review Boards;Knowledge;Lead;Leadership;Logistics;Medulloblastoma;Molecular;Multicenter Studies;multidisciplinary;MYCN gene;neuro-oncology;Participant;Pathology;Patients;Phase;Phase I/II Clinical Trial;Pre-Clinical Model;precision medicine;predictive marker;repository;Research;Research Personnel;Resistance;Role;Sampling;Site;Structure;Testing;therapeutic target;Topoisomerase;Treatment Protocols;tumor;Tumor Biology;Tumor Tissue;United States National Institutes of Health;virtual

PROJECT_TITLE: Development of new treatments for rare CNS tumors


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: ADORO, STANLEY  (contact)

PROJECT_TERMS: Address;Age;Animal Model;Blood;Blood Cells;Cell Differentiation process;Cell Physiology;Cells;Cellular biology;Chronic;Defect;design;Development;Disease;exhaustion;Functional disorder;Genes;genome integrity;Genomics;Goals;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic Neoplasms;Hematopoietic stem cells;Homeostasis;Human;Immune;Impairment;Investigation;Knowledge;Link;Macrophage;Maintenance;Malignant - descriptor;Mammalian Cell;Mediator;multicatalytic endopeptidase complex;Myeloid Leukemia;novel;OmpR protein;Pathway interactions;programs;Protein Biosynthesis;Proteins;Proteome;Proteomics;proteostasis;proteotoxicity;Regulation;Research;response;Role;Sampling;Shapes;Signal Pathway;Stress;System;T-Cell Leukemia;T-Lymphocyte;Testing;thymocyte;Tissues;transcriptomics;translational engagement;Ubiquitin;Viral Cancer;Virus Diseases;Work

PROJECT_TITLE: Proteostasis regulators in blood cell development and function


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Hematology;Hodgkin's Disease;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: ROSCHEWSKI, MARK  (contact)

PROJECT_TERMS: Africa South of the Sahara;Burkitt Lymphoma;CD8-Positive T-Lymphocytes;Disease;disease natural history;Disease remission;Enrollment;Epstein-Barr Virus-Related Lymphoma;Extranodal;HIV;Hodgkin Disease;Human Herpesvirus 4;Immune checkpoint inhibitor;Immunity;In complete remission;Individual;Kinetics;large cell Diffuse non-Hodgkin's lymphoma;Large-Cell Immunoblastic Lymphoma;low income country;Nature;novel;Patients;Phase Ib/II Clinical Trial;Plasma;prognostic;Relapse;response;Safety;T-Cell Lymphoma;Translational Research;tumor

PROJECT_TITLE: Checkpoint inhibitor treatment for EBV+ lymphoma among HIV+ individuals


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Orphan Drug;Rare Diseases

PI_NAMEs: LIN, FRANK  (contact)

PROJECT_TERMS: Calendar;Cells;Collaborations;efficacy evaluation;Enrollment;Head and Neck Cancer;industry partner;Institutional Review Boards;kidney cell;Lung;Maximum Tolerated Dose;Neuroendocrine Tumors;Paraganglioma;Participant;participant enrollment;Pharmacologic Substance;Phase I/II Clinical Trial;Pheochromocytoma;Process;radioligand;response;Retreatment;Site;Somatostatin Receptor;tumor;United States National Institutes of Health

PROJECT_TITLE: Pb212 VMT alpha NET in treatment and re-treatment of SSTR+ tumors


PI_NAMEs: RAJAGOPAL, PADMA  (contact)

PROJECT_TERMS: Bioinformatics;Blood;cancer prevention;cancer risk;cancer type;Classification;ClinVar;Data;disease-causing mutation;DNA;DNA Sequence Alteration;DNA sequencing;Etiology;exome;experience;Family;Family member;Genes;genetic variant;Genotype-Tissue Expression Project;Germ Lines;Hereditary Malignant Neoplasm;Housekeeping Gene;Inherited;insertion/deletion mutation;Malignant Neoplasms;Methylation;Mutation;nanopore;NCI Center for Cancer Research;next generation;Pathogenicity;Patients;Recording of previous events;Reproducibility;Risk;RNA;RNA Splicing;Sampling;Single Nucleotide Polymorphism;symposium;Syndrome;Technology;Testing;TP53 gene;transcriptome sequencing;tumor;Validation;Variant;variant of interest;Whole Blood

PROJECT_TITLE: Long-Read DNA Sequencing and RNA Sequencing in LFS-Like Families


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetic Testing;Genetics

PROJECT_TERMS: CCR;Clinical;Clinical Trials;Detection;Image;Malignant Neoplasms;National Human Genome Research Institute;Natural History;Neoplasms;Participant;Patient Recruitments;Persons;pregnant;prenatal testing;recruit;Recruitment Activity;Reporting;Test Result;Testing;Woman

PROJECT_TITLE: IDENTIFY Study: Natural History of Maternal Neoplasia


PI_NAMEs: SINGER, DINAH S. (contact)

PROJECT_TERMS: Active Sites;Alternative Splicing;Architecture;Binding;Binding Proteins;Bromodomain;c-myc Genes;Cellular Stress;Chromatin;chromatin remodeling;cohesin;Complex;Disease;Dissociation;DNA Polymerase II;Early Gene Transcriptions;Enzymes;EP300 gene;epithelial to mesenchymal transition;Event;Genes;Genetic Transcription;genome-wide;Heart Diseases;Histone Acetylation;histone acetyltransferase;Human;Immediate-Early Genes;Immune;Immune response;Inflammatory;Inflammatory Response;JNK-activating protein kinase;Kidney Diseases;Malignant Neoplasms;MAPK8 gene;Mediating;member;Mitosis;Mitotic;Nervous System Disorder;novel;Nucleoplasm;Nucleosomes;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Productivity;promoter;prostate cancer cell;Protamine Kinase;Protein Dephosphorylation;Protein Family;recruit;Regulation;release factor;Reporting;response;RNA;RNA Splicing;Role;Signal Transduction;Stimulus;Stress;TAF7 gene;thymocyte;Tissues;Transcription Coactivator;Transcription Elongation;transcription factor;Transcription Initiation;Transcriptional Elongation Factors;Work

PROJECT_TITLE: Regulation of BRD4 Function


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

PI_NAMEs: YOHE, MARIELLE  (contact)

PROJECT_TERMS: Alveolar;Apoptosis;ATAC-seq;cancer type;Cell Differentiation process;Cell Line;cell motility;Cell Proliferation;Cells;Childhood Soft Tissue Sarcoma;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Remodeling Factor;Chromosomal translocation;Classification;Co-Immunoprecipitations;CTNNB1 gene;Data;Data Analyses;experimental study;FGFR4 gene;FOXO1A gene;Gene Cluster;Genes;Growth;HDAC2 gene;healing;Histologic;ISWI;Knock-out;Methods;migration;Mutation;Myoblasts;myogenesis;Oncogenes;PAX3 gene;PAX7 gene;Phenotype;PIK3CA gene;prevent;Process;Proliferating;Protein Family;Protein Isoforms;Proteins;RALA gene;Rhabdomyosarcoma;Role;Running;Skeletal Muscle;skeletal muscle differentiation;SMARCA1 gene;Switching Complex;System;targeted cancer therapy;TP53 gene;transcriptome sequencing;transcriptomics;tumor;tumor progression;Tumor Suppressor Proteins;tumorigenesis;tumorigenic

PROJECT_TITLE: The role of SMARCA1 in Rhabdomyosarcoma and Skeletal Muscle Differentiation


NIH_SPENDING_CATS: Cancer;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

PI_NAMEs: BOUFRAQECH, MYRIEM  (contact)

PROJECT_TERMS: anaplastic thyroid cancer;ataxia telangiectasia mutated protein;bone;BRAF gene;Brain;cancer cell;cell killing;Cell Survival;Clinical Data;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Coupled;CRISPR screen;Disease;DNA Damage;Exhibits;Genes;Genetic Determinism;genome-wide;Genomic Instability;Goals;Human;improved;In Vitro;in vivo;inhibitor;Knock-out;knockout gene;Libraries;Link;Lung Carcinoma;Malignant Epithelial Cell;Malignant neoplasm of thyroid;Malignant Neoplasms;MAP Kinase Gene;Mediating;Mutation;novel;Oncogenic;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Pre-Clinical Model;precision oncology;Reporting;Resistance;resistance mechanism;response;Site;targeted agent;targeted treatment;Therapeutic;Toxic effect;treatment response;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Unlocking mechanisms of resistance to targeted therapy in thyroid cancer


NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Rare Diseases

PI_NAMEs: SALOURA, VASSILIKI  (contact)

PROJECT_TERMS: Antigen Presentation;antitumor effect;arm;cancer cell;disorder control;Dose;drug withdrawal;efficacy evaluation;Eligibility Determination;EZH2 gene;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Hematologic Neoplasms;HPV-negative head and neck cancer;In complete remission;inhibitor;Intervention;ipilimumab;Lead;novel;partial response;patient population;Patients;PDL1 inhibitors;pembrolizumab;Peripheral;Phase;phase 2 study;premature;Progression-Free Survivals;Prostate;Randomized;Recommendation;Renal Cell Carcinoma;response;Safety;safety study;Stable Disease;T-Cell Lymphoma;Urothelial Cell

PROJECT_TITLE: Valemetostat in combination with pembrolizumab in head and neck cancer


PI_NAMEs: REILLY, KARLYNE M (contact)

PROJECT_TERMS: Adolescent and Young Adult;Affect;Binding;Biological;Biological Models;Biology;Cancer cell line;Cell Death;Cell Line;Cell membrane;Cell Nucleus;Cells;Characteristics;Chordoma;Chromatin;Clinical;Clinical Trials;Clinical Trials Design;cohort;Combined Modality Therapy;Dependence;design;drug candidate;Drug Modelings;drug repurposing;Drug Screening;Drug Synergism;drug testing;effective therapy;Energy-Generating Resources;Engineering;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;epigenomics;Experimental Designs;experimental study;Extracellular Matrix Proteins;EZH2 gene;FDA approved;Goals;Growth;Growth Factor;Health Sciences;high throughput screening;Histology;improved;inhibitor;insight;Intervention;Kidney;Learning;Libraries;Liver;Malignant Neoplasms;Metabolic;metabolic abnormality assessment;Modeling;Molecular;Molecular Conformation;molecular subtypes;novel;Nutrient;Oregon;Organ;Pathway interactions;patient derived xenograft model;Patients;Pattern;Pediatric Neoplasm;Pharmaceutical Preparations;Population;Prognosis;rare cancer;Ras Signaling Pathway;Reagent;Research;Skin;SMARCB1 gene;solute;Starvation;Stomach;targeted treatment;Testing;Tissue Microarray;Tissues;tool;transcriptomics;trial design;tumor;Universities;Visualization;Work

PROJECT_TITLE: Biology and molecular vulnerabilities in SMARCB1-deficient tumors


PI_NAMEs: YANG, JAMES C (contact)

PROJECT_TERMS: 3-Dimensional;Adoptive Cell Transfers;Antigens;Autologous;cancer regression;Carcinoma;Cholangiocarcinoma;Clinical;Clinical Protocols;Colon Carcinoma;Data;Immune;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Mutation;neoantigens;Organoids;Orphan;Patients;response;screening;success;T cell response;T cell therapy;T-Lymphocyte;Technology;Treatment Failure;tumor;Tumor Antigens;two-dimensional

PROJECT_TITLE: Studying Immune Recognition of Epithelial Cancers Using Organoids


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy

PI_NAMEs: KRISHNA, SRI  (contact)

PROJECT_TERMS: Alleles;Antibodies;antigen-specific T cells;Appointment;Bar Codes;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Separation;Cell Therapy;Cells;Cellular immunotherapy;Common Neoplasm;DNA;driver mutation;engineered T cells;Engineering;Epithelium;Equipment;gene therapy;Haplotypes;Histocompatibility Antigens Class I;HLA Antigens;Human;invention;KRAS2 gene;Libraries;Malignant Neoplasms;mutant;Mutate;Mutation;National Cancer Institute;NCI Center for Cancer Research;neoantigens;Oligonucleotides;Papillomavirus;Patients;Peptides;peripheral blood;Phenotype;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;Proteomics;Reagent;recruit;Research;Research Personnel;Sampling;Source;T cell receptor repertoire sequencing;T-Cell Receptor;T-Lymphocyte;Technology;tenure track;Tissue Sample;transcriptome sequencing;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;Virus

PROJECT_TITLE: Identifying antitumor T cell receptors for cellular immunotherapy


NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LUO, JI  (contact)

PROJECT_TERMS: adult stem cell;Affect;Age;age effect;age related;age related decline;Aging;Alveolar;alveolar type II cell;Bone Marrow Transplantation;cancer initiation;Cancer Model;Cells;Chemicals;Computer software;Cutaneous;Development;Disease;Ectoderm;Endoderm;Environment;epigenomics;experimental study;Gene Expression Profile;Genetic;human old age (65+);Immune;Immune response;Immune system;In Vitro;Inflammation;Intervention;Intrinsic factor;keratinocyte;Lesion;Lung;Lung Adenocarcinoma;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Metastatic Neoplasm to the Lung;Modeling;Monitor;mouse model;Mus;Mutagens;mutant;Myeloid Cells;old mice;Oncogenes;Oncogenic;Phosphopeptides;phosphoproteomics;Phosphotransferases;Play;Primary Cell Cultures;Process;ras Oncogene;Ras Signaling Pathway;Role;self-renewal;Signal Transduction;single-cell RNA sequencing;Skin;Skin Cancer;stem cells;Study models;Testing;Tissues;transcriptomics;Transplantation;tumor;tumor behavior;tumor growth;tumor initiation;tumor microenvironment;Tumor Promotion;Tumor Suppressor Genes;Tumor-associated macrophages;tumorigenesis;tumorigenic;Tumorigenicity

PROJECT_TITLE: Factors that influence age-dependent Ras mutant cancer development in mice


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy

PROJECT_TERMS: Adoptive Cell Transfers;antigen-specific T cells;Appointment;Blood;cancer cell;cancer immunotherapy;Cancer Patient;Carcinoma;CD86 gene;CD8B1 gene;Cell Physiology;Cell Proliferation;Cell Surface Proteins;Cell Therapy;Cells;Deposition;Disseminated Malignant Neoplasm;draining lymph node;Engineering;Equipment;exhaust;exhaustion;Failure;Frequencies;Functional disorder;Genetic Transcription;Goals;Human;human model;immune checkpoint blockade;Immunity;Impairment;improved;In Vitro;Journals;Mediating;Membrane Proteins;mouse model;National Cancer Institute;NCI Center for Cancer Research;neoantigens;Neoplasm Metastasis;Patients;peripheral blood;Phenotype;Population;Postbaccalaureate;Postdoctoral Fellow;Preparation;programmed cell death protein 1;Property;prospective;protein biomarkers;protein expression;Publishing;Reagent;recruit;Research;Research Personnel;Sensitivity and Specificity;Solid;Source;stem;success;T cell differentiation;T-Lymphocyte;Technology;tenure track;Testing;Tissues;transcriptomics;tumor;Tumor Expansion

PROJECT_TITLE: Studying phenotypic states of antitumor human T cells


PI_NAMEs: KOCHENDERFER, JAMES  (contact)

PROJECT_TERMS: American Society of Hematology;Animals;Autoimmune Diseases;CAR T cell therapy;chimeric antigen receptor T cells;Clinical Trials;Development;Goals;In Vitro;in vitro testing;invention;Laboratory Study;Legal patent;Malignant Neoplasms;meetings;Mus;Play;Preparation;Role;Series;T-Cell Receptor;T-Lymphocyte;Testing;Work;γδ T cells

PROJECT_TITLE: Development of CAR T cells targeting T-cell malignancies


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Rare Diseases

PROJECT_TERMS: Acute;Acute Myelocytic Leukemia;Antigens;Autologous;Cell Line;chimeric antigen receptor T cells;Clinical Protocols;clinical trial enrollment;Collaborations;Dysmyelopoietic Syndromes;Genes;genetically modified cells;Goals;Hematologic Neoplasms;Human;In Vitro;mouse model;Mus;Mutate;Mutation;Myeloproliferative disease;neoantigens;participant enrollment;Phase I Clinical Trials;preclinical study;Process;Protocols documentation;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;therapy development;Time;Writing

PROJECT_TITLE: Adoptive T-cell Therapies Targeting Mutations in Hematologic Malignancies