NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: PROJECT NARRATIVE Great attention has been paid to the potential role of the external globus pallidus (GPe) in motor control and the aberrant GPe neuronal activity is closely associated with movement deficits in both PD patients and Parkinsonian animal models. Our preliminary results show that the activity of newly identified glutamatergic neurons in the GPe may contribute to PD-related behavioral dysfunction in dopamine-depleted mice. Thus, we will elucidate the anatomical and functional organization of GPe glutamatergic neurons to improve our understanding of GPe circuitry and its contribution to PD-related behavioral dysfunction in animal models for the progressive PD.

PI_NAMEs: LEUTGEB, STEFAN ;LIM, BYUNGKOOK  (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: Address;Affect;Anatomy;Animal Model;Animals;associated symptom;Attention;Basal Ganglia;Basal Ganglia Diseases;Behavior;Behavioral;behavioral impairment;Behavioral Symptoms;Brain region;Cell Nucleus;cell type;cognitive function;Corpus striatum structure;Data;Disease;Dopamine;dopaminergic neuron;Dose;Electrophysiology (science);field study;flexibility;Functional disorder;Genetic;Genetic Suppression;Globus Pallidus;Glutamates;Heterogeneity;Human;improved;in vivo;Individual;Investigation;Mediating;Methods;mitopark mouse;Modeling;Molecular;molecular marker;Motor;motor behavior;motor control;motor deficit;mouse model;Movement;Movement Disorders;Mus;Nature;neural;neural circuit;neuroadaptation;neuromechanism;neuron loss;Neurons;Neurotoxins;novel;optogenetics;Output;Oxidopamine;Parkinson Disease;parkinsonian animal;Pathway interactions;Patients;Population;population based;Positioning Attribute;Progressive Disease;Reporting;Research;Role;Signal Transduction;Synapses;Techniques;Time;Viral

PROJECT_TITLE: Role of Glutamatergic Neurons in External Globus Pallidus in the Behavioral Deficits in Animal Models of Progressive Dopamine Depletion

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE In numerous human diseases the insulating layer around nerves in the brain, called myelin, is damaged and must be efficiently cleared before tissue repair can occur. We have developed advanced methodologies for inducing, manipulating and observing myelin degeneration and repair in the live brain in real time. Using these tools this project will investigate how myelin debris are dynamically cleared by resident glial cells and the consequences of defective clearance on tissue maintenance and myelin repair.

PI_NAMEs: HILL, ROBERT  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Ablation;Aging;Animal Model;Animals;Apoptotic;Astrocytes;Axon;Brain;Cell Death;Cell membrane;Cell Surface Extensions;cell type;Cells;Cellular Structures;Cessation of life;Color;Communication;CSPG4 gene;Degenerative Disorder;Demyelinating Diseases;Demyelinations;Detection;Development;Digestion;Event;Excision;experience;experimental study;Failure;Fluorescence;fluorophore;Functional disorder;Generations;Genetic;genetic manipulation;gray matter;human disease;human model;Image;imaging modality;Imaging Techniques;Impaired cognition;in vivo;in vivo imaging;Injury;intravital imaging;Investigation;Knowledge;Label;Lipids;Maintenance;Metabolic;Metabolism;Methodology;Methods;Microglia;Modeling;Molecular;motor impairment;Multiple Sclerosis;Mus;Mutant Strains Mice;Mutation;Myelin;myelin degeneration;Myelin Sheath;Nerve;neural;neural circuit;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;Oligodendroglia;optical imaging;Organ;Pathway interactions;Pattern;Phagocytes;Phagocytosis;phosphatidylserine receptor;Play;Population;Process;progenitor;receptor;Receptor Signaling;remyelination;repaired;Reporter;Resolution;response;Rest;Role;Sensory;Signal Transduction;Specific qualifier value;Speed;Stereotyping;success;Techniques;Testing;Time;tissue repair;Tissues;tool;Transgenic Organisms;transmission process;TREM2 gene

PROJECT_TITLE: Glial Mechanisms Governing the Removal and Repair of Degenerating Myelin

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Epilepsy;Lung;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sudden Unexpected Death in Epilepsy (SUDEP) is defined as the sudden, unexpected, and unexplained death of a person with epilepsy and accounts for between 8 and 17% of all epilepsy-related deaths. Increasing evidence supports breathing cessation as a primary cause of death following a seizure. Using a novel mouse model of SUDEP, we propose to elucidate the underlying mechanisms of breathing cessation during and after seizures, possibly creating new therapeutic avenues for SUDEP.

PI_NAMEs: PATEL, MANOJ K (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Apnea;Benchmarking;Bradycardia;Brain Stem;Breathing;Carbon Dioxide;Cardiac;cardiac pacing;Cause of Death;Cell Nucleus;Cessation of life;Clinical;clinically relevant;Complex;Development;Electroencephalography;Electrophysiology (science);Epilepsy;epileptic encephalopathies;expiration;Failure;gain of function mutation;Heart Arrest;heart function;Homeostasis;Impairment;in vivo;ineffective therapies;insight;knock-down;Monitor;mortality;Motor Seizures;mouse model;Mus;Muscle;Mutation;National Institute of Neurological Disorders and Stroke;neural circuit;Neurologic;Neurons;neuroregulation;new therapeutic target;novel;novel therapeutics;optogenetics;Oxygen;Pathology;patient population;Patients;Persons;Phase;Population;prevent;Prevention strategy;Process;Recovery;Refractory;Reporting;Research;Respiration Disorders;respiratory;Respiratory Diaphragm;Risk;Risk Factors;Role;SCN8A encephalopathy;SCN8A gene;Seizures;small hairpin RNA;Sodium Channel;Stroke;sudden unexpected death in epilepsy;Symptoms;Techniques;Testing;Time;Tonic - clonic seizures;ventilation;Viral;Vulnerable Populations;years of life lost

PROJECT_TITLE: Role of brainstem cardiorespiratory neurons in SUDEP

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative: Cranial trauma, tumor invasion, cerebrovascular disease, and brain surgeries all can cause defects to the dura mater. Xenogeneic grafts, when properly treated and handled, have the potential to preserve the overall architecture of the matrix and provide enhanced structural support. This study aims to answer the question “Do acellular xenogeneic dura grafts elicit a less deleterious immune response than naturally derived commercial grafts and maintain structural integrity over the long term for in vivo studies?”

PI_NAMEs: WILLIAMS, LAKIESHA NICOLE (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Adhesions;Antibodies;Antigen Presentation;Architecture;Biological;Brain;brain surgery;Cadaver;Cell Proliferation;Cell Survival;Cell-Matrix Junction;Cephalic;Cerebrospinal Fluid;Cerebrovascular Disorders;Chronic Headaches;Cicatrix;Clinic;Clinical;Collagen;Collagen Fiber;Collagen Type I;Connective Tissue;Consensus;Defect;Dura Mater;Elastic Fiber;Elastin;Electron Microscopy;Euthanasia;Evaluation;Extracellular Matrix;Extracellular Matrix Proteins;Extravasation;Failure;Family suidae;Fibroblasts;Freeze Drying;Genetic;Gold;Growth Factor;Health;Histologic;Human;immune cell infiltrate;Immune response;Immunologics;Implant;implantation;improved;In Vitro;in vitro Assay;in vitro Model;in vivo;infection risk;Inflammation;Instruction;Knowledge;Laminin;Leukocytes;Libraries;Life;light microscopy;Macrophage;Maps;Mechanics;Metabolic;Modeling;Morbidity - disease rate;mortality;neutrophil;patched protein;Patient Selection;Patients;Performance;Perfusion;Polymers;pre-clinical;preservation;pressure;primary outcome;Procedures;Process;Proliferating;Property;Proteins;PTPRC gene;Rattus;repaired;replacement tissue;Research;response;Rodent;Role;Rupture;scaffold;seal;Secure;Site;Source;Stains;Stretching;Structure;Subdural Hematoma;success;Surgeon;Testing;Time;tissue fixing;tissue regeneration;Tissues;Trauma;Tumor Cell Invasion;Work;wound healing

PROJECT_TITLE: In vitro and in vivo assessments of xenogeneic cranial dura mater and naturally derived commercial dural grafts

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The purpose of this study is to develop and test the feasibility and preliminary impact of a robust physical activity program among individuals while incarcerated in jail. Based in Social Cognitive Theory and through focus groups and key informant interviews, we will identify theoretical constructs and attributes of physical activity among individuals incarcerated. From formative research, we will develop and evaluate the feasibility and preliminary evidence of impact (Social Cognitive Theory constructs, sleep quality, stress, anxiety symptoms, and depression symptoms) of a physical activity program among individuals incarcerated in jail using a pilot clustered randomized control trial.

PI_NAMEs: CAMPLAIN, RICKY L. (contact)

PROGRAM_OFFICER_NAME: HERREN, OLGA MARINA

PROJECT_TERMS: acceptability and feasibility;Acute;acute stress;American;Anxiety;anxiety symptoms;Arizona;arm;Behavior;Behavioral;Black Populations;Blood Pressure;career;career development;Charge;Clinical Trials;community planning;Correctional Institutions;County;Data;Dedications;depressive symptoms;Development;Development Plans;Disease;Disparity;Economically Deprived Population;Effectiveness;efficacy testing;Environment;Epidemiology;ethnic minority;ethnic minority population;Evaluation;Exercise;expectation;feasibility testing;Female;Focus Groups;Funding;Future;Goals;Health;health disparity;Hour;Housing;Hypertension;Imprisonment;improved;improvement on sleep;Individual;Inequity;Informal Social Control;informant;Intervention;Interview;Jail;Latina Population;Latino Population;Length of Stay;male;Mental Depression;Mental disorders;Mentors;Methods;moderate-to-vigorous physical activity;Native Americans;Outcome;Outcome Study;people of color;Personal Satisfaction;Physical activity;Physiological;Politics;poor sleep;Population;programs;racial minority;racial minority population;Randomized;Randomized, Controlled Trials;Recovery;Recreation;recruit;Regimen;Research;resilience;Resources;Rural;safety outcomes;Schedule;Schools;sedentary;Self Efficacy;severe mental illness;sleep quality;social;social cognitive theory;Social support;socioeconomic disadvantage;socioeconomics;Stress;stress reduction;stress symptom;Structure;Substance abuse problem;substance use;Symptoms;Testing;theories;therapy development;Time;Training;treatment arm

PROJECT_TITLE: Promoting Recreation Time among Individuals Incarcerated in Jail


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Severe malaria kills hundreds of thousands of children across sub-Saharan Africa annually, and its biological basis is unknown. This study aims to identify the pathogenic malaria proteins responsible for severe disease in Zambian children and adults using cutting-edge sequencing and microarray technology. We will determine whether these pathogenic proteins are similar to those previously identified in Malian children, raising the possibility that common subsets of parasite variant surface antigens associated with severe malaria in children and adults across Africa could form the basis of a vaccine or therapy.

PI_NAMEs: IPPOLITO, MATTHEW MICHAEL;TRAVASSOS, MARK A (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Accounting;Acute;Adult;Africa;Africa South of the Sahara;Antibody Response;antigen detection;Antigens;Artemisinins;Base Pairing;Biological;Biological Products;case control;Central Africa;Cerebral Malaria;Cessation of life;Child;Childhood;Chinese Herbs;Clinical;Complex;Custom;Data;design;Development;differential expression;Disease;disease-causing mutation;drug development;Erythrocytes;experience;Gene Expression Profile;Genes;Genome;Geography;Human;Immune;Immunity;Individual;Infection;Length;Life Cycle Stages;Malaria;malaria infection;malarial anemia;Malawi;Mali;mathematical model;Microarray Analysis;Morbidity - disease rate;mortality;new therapeutic target;novel;novel strategies;novel therapeutics;novel vaccines;Parasites;Pathogenesis;Pathogenicity;Patients;Pharmaceutical Preparations;Plasmodium falciparum;Play;Prospective cohort;Protein Microchips;Proteins;receptor;RNA Sequences;Role;Serology;Site;Subgroup;Surface;Surface Antigens;Syndrome;Transcript;transcriptome sequencing;vaccine development;Vaccine Therapy;Vaccines;Variant;Virulent;Whole Blood;Zambia

PROJECT_TITLE: Parasite variant surface antigen expression and immune gaps in severe malaria

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Cancer;Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention

ORG_DEPT: NEUROSCIENCES

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative Nervous system involvement has remained as one of the most important complications of chemotherapy despite development of novel and more effective anti-cancer therapies and the molecular mechanism by which many of the chemotherapy drugs cause axonal injury and result in peripheral neuropathies is poorly understood. Furthermore, there are no effective therapies that prevent or reverse axonal degeneration seen in chemotherapy-induced peripheral neuropathy (CIPN). This study is aimed at testing whether a key molecule called MAP4K4 plays an important role in neurotoxicity from chemotherapy and whether inhibiting this protein is a viable therapeutic target to prevent CIPN.

PI_NAMEs: HOKE, AHMET  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Afferent Neurons;anti-cancer;Applications Grants;axon injury;axonal degeneration;Bortezomib;cancer therapy;Chemicals;chemotherapy;Chemotherapy-induced peripheral neuropathy;Chemotherapy-Oncologic Procedure;chronic neuropathic pain;Cisplatin;Clinical Research;Data;Development;Distal;Drug usage;effective therapy;experimental study;Family;Genetic;Grant;In Vitro;in vivo;in vivo Model;inhibitor;kinase inhibitor;knock-down;Knockout Mice;Life;MAP4K4 gene;member;Molecular;Morbidity - disease rate;Nervous System;Neurologic;Neurons;neuroprotection;neurotoxicity;new therapeutic target;novel;Nude Mice;Paclitaxel;Pathway interactions;Peripheral;Peripheral Nervous System Diseases;Pharmaceutical Preparations;pharmacologic;Play;prevent;Proteins;Quality of life;Resistance;Role;Sensory;Small Interfering RNA;Solid Neoplasm;Specificity;Spinal Ganglia;Testing;therapeutic target;Toxic effect;Toxicity due to chemotherapy

PROJECT_TITLE: MAP4K4 inhibition to prevent CIPN

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE  Bacterial pathogens pose a serious threat to human health. Developing drugs to treat infections caused by pathogens that grow inside host cells is particularly challenging as this environment protects them from exposure to many antibiotics. The goal of this research is to define critical strategies employed by these pathogens to establish an infection to identify novel targets for therapeutic intervention.

PI_NAMEs: O'CONNOR, TAMARA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Aerosols;Alveolar Macrophages;anti-microbial drug;Antibiotics;antimicrobial;Bacteria;Binding;Biochemical;Cell Death;cell envelope;Cell surface;Cells;Communicable Diseases;Compensation;contaminated water;Cyclic AMP;Cyclic Nucleotides;Cytoplasm;Defect;Deposition;detection platform;Development;Disease;emerging antibiotic resistance;Ensure;Environment;Event;Exposure to;Future;genomic locus;Goals;Growth;Health;Human;Immune;Infection;Inhalation;insight;Knowledge;Legionella;Legionella pneumophila;Legionnaires' Disease;Life;Ligands;Link;Lipoprotein (a);Location;man;Mediating;Mediator;member;Membrane;Membrane Proteins;Metalloproteases;microbial;Molecular;Monitor;new therapeutic target;novel;novel strategies;novel therapeutics;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Perforation;periplasm;Permeability;Pharmaceutical Preparations;Play;Pneumonia;preservation;Process;Production;programs;Proliferating;Proteins;Research;Research Proposals;response;Role;Rupture;Second Messenger Systems;sensor;sensory system;Signal Pathway;Signal Transduction;Signal Transduction Pathway;System;Therapeutic Intervention;Type IV Secretion System Pathway;Vacuole;Virulence;Water;Work

PROJECT_TITLE: Dissecting a sensory system for Legionella replication vacuole integrity

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Rural Health;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Rural Americans have had poorer health profiles than their urban peers since the 1980s, and the gap has widened over time. This project will focus on rural-urban and within-rural disparities in Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD), which in 2020, affected approximately 11% of Americans 65 and older and 35% of those 85 and older. Analyses will 1) produce novel and robust population estimates of dementia prevalence in rural and urban America; and 2) characterize the types of rural places and people most affected by dementia in the United States.

PI_NAMEs: ZACHER, MEGHAN  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Adult;Affect;Age;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;American;Caregivers;Cessation of life;Characteristics;Country;County;Data;Death Rate;Dementia;dementia risk;Disadvantaged;Disease;Disparity;Economic Factors;Ethnic Origin;experience;Farm;Gender;Goals;Health;Health and Retirement Study;health care availability;health care quality;health data;health disparity;Heterogeneity;human old age (65+);Individual;Industry;insight;Institution;loved ones;manufacture;Masks;Measures;Mining;Molds;mortality;mortality disparity;novel;older adult;Pattern;peer;Persons;Population;population health;Prevalence;Race;Research;Research Personnel;Rural;rural America;rural Americans;rural area;Rural Community;rural counties;rural disparities;Rural Health;Rural Population;rural residence;rural setting;rurality;Services;Shapes;sociodemographic factors;sociodemographics;Socioeconomic Status;Stereotyping;Surveys;Time;trend;United States;urban area;Urban Community;urban disparity;Variant

PROJECT_TITLE: Rural-urban and within-rural disparities in Alzheimer's disease and Alzheimer’s disease-related dementias

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Genomics hold a great potential to improve human health and well-being, and assist in the preservation of the biological ecosystems that humanity depends upon. Reference genomic resources, and particularly reference genomes, are fundamental assets to perform and assist the analyses of most genomic data sets. With this proposal, we will provide a key set of efficient, interoperable, reproducible and extensible algorithms and tools to improve the quality of the reference genomes that are deposited in the public archives.

PI_NAMEs: FORMENTI, GIULIO  (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Address;Algorithm Design;Algorithmic Software;Algorithms;Archives;Biological Preservation;Code;Communities;comparative genomics;Complex;Computer software;Computing Methodologies;Consensus;Data;Dedications;Deposition;design;Development;Diploidy;Disease;Ecosystem;Evaluation;experience;file format;Generations;Genes;Genome;genome resource;genomic data;Genomic Library;genomic tools;Genomics;Genotype;Graph;Health;Human;Human Genome;Human Genome Project;human pangenome;Humanities;improved;infancy;International;interoperability;Libraries;Maintenance;Manuals;Memory;Methods;Modeling;Names;Noise;Output;parallelization;Performance;Personal Satisfaction;Phase;Phenotype;Planet Earth;portability;Process;Programming Languages;public database;Quality Control;reference genome;Reproducibility;Software Tools;Speed;statistics;Structure;Technology;telomere;tool;tool development;trait;Validation;vertebrate genome;Work

PROJECT_TITLE: Gfastar: a C++ library and a tool suite to aid Telomere-to-Telomere genome assembly

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: PROJECT NARRATIVE Effective drug treatment for Alzheimer’s disease (AD) may well be on the horizon. The objective of our proposal is to develop a digital health resource for continuous cognitive assessment in a well-characterized cohort to identify and validate novel digital cognitive measures and develop new models for cognitive health to aid early detection, treatment, and prevention of AD.

PI_NAMEs: AU, RHODA  (contact);KOLACHALAMA, VIJAYA B.;LIN, HONGHUANG

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Achievement;adjudication;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Autopsy;Biological;Biological Markers;Blood;Blood Vessels;blood-based biomarker;Boston;Brain;brain health;Brain imaging;brain magnetic resonance imaging;brain volume;Cerebrospinal Fluid;Cessation of life;Clinical;clinical center;Clinical Data;Cognitive;cognitive testing;cohort;Collection;cost;Data;Data Collection;data resource;Dementia;dementia risk;Detection;Devices;Diagnosis;digital;Digital biomarker;digital data;digital health;digital models;digital phenotyping;digital technology;Disease;disorder prevention;disorder risk;Early Diagnosis;Frequencies;Health;Health Resources;Health Technology;Hippocampus;Individual;interest;Internet of Things;Intervention;Life Cycle Stages;machine learning model;Measures;Mediation;Methods;Modeling;Monitor;MRI Scans;Nerve Degeneration;Neuroanatomy;neurofilament;neuropathology;Neuropsychological Tests;novel;Onset of illness;Paper;Participant;Patients;Pharmacotherapy;phase III trial;Phenotype;Plasma;Positron-Emission Tomography;pre-clinical assessment;Predisposition;Recommendation;Reporting;Research;Risk;Risk Behaviors;sensor;smartphone application;Standardization;Structure;success;Symptoms;tau Proteins;Thick;Time;United States Food and Drug Administration;Universities;Vascular Diseases;vascular risk factor;White Matter Hyperintensity

PROJECT_TITLE: Digital Cognitive Assessment of Preclinical Alzheimer's Disease and Related Dementias

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Psychosocial distress is a common comorbidity associated with the glaucoma experience and left untreated can contribute to worse outcomes, including worse vision-related quality-of-life and disease severity, faster rates of visual field progression, and poor follow-up and medication adherence, and glaucoma comprehension. The work described in this proposal will introduce and validate an automated assessment and treatment screening program for distress in glaucoma, through innovative predictive modeling of existing healthcare and research database systems. The outcome of this project will shed light on the importance of recognizing distress in the course of glaucoma clinical care, and provide evidence to support new approaches and paradigms to assess and treat glaucoma-induced distress.

PI_NAMEs: BERCHUCK, SAMUEL ISAAC (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;algorithm training;Algorithms;Anxiety;Artificial Intelligence;artificial intelligence algorithm;automated assessment;Automation;Award;Behavior Therapy;Behavioral Sciences;Bioinformatics;Biometry;Blindness;Calibration;career development;Caring;Characteristics;Chronic;Clinic;Clinical;clinical care;Clinical Data;clinical decision-making;clinical practice;Clinical Research;clinical risk;comorbidity;Comprehension;Coping Skills;cost;Data;Data Collection;Data Science;Data Set;Database Management Systems;Databases;design;Development;diagnosis standard;Discrimination;Disease;disorder control;Distress;Effectiveness;efficacy evaluation;Electronic Health Record;Ensure;evidence base;experience;eye center;Familiarity;Focus Groups;follow-up;Glaucoma;Goals;Health;Health Professional;Health Sciences;Healthcare;high risk;Image;improved;innovation;instrument;Intervention;intervention program;intervention refinement;Laboratories;Left;Machine Learning;Measures;Medical;Medical Electronics;medication compliance;Mental Depression;Mentors;mindfulness-based stress reduction;model development;multidisciplinary;Nature;novel strategies;Oncology;Ophthalmologist;Outcome;Outcome Measure;Patient Care;Patient Compliance;Patient Outcomes Assessments;patient screening;Patient Self-Report;Patients;Performance;Personal Satisfaction;Phase;Population;population health;Postdoctoral Fellow;predictive modeling;prevent;programs;Property;prospective;Protocols documentation;Provider;Psychiatry;psychosocial;Quality of life;Questionnaires;Randomized;randomized, clinical trials;Recommendation;Records;Registries;Research;Research Design;Research Personnel;retention rate;Risk Estimate;Risk Factors;screening;screening program;Severity of illness;skills;standard measure;Stress and Coping;Surveys;Techniques;Telephone;Testing;Time;Training;Validation;Vision;Visit;Visual Fields;Work

PROJECT_TITLE: Development of a program to assess and treat distress in glaucoma patients using an automated EHR-derived AI algorithm

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences;Pediatric

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  Preterm (PT) birth is associated with elevated risks for language impairments, but we know little about why and how PT-related individual differences in language acquisition emerge. The present proposal will examine infant-parent coordinated visual attention as a key mechanism underlying the developmental cascades from PT- induced alterations in basic attention functions and motor abilities to real-time word learning performance. The findings can improve the precision in predicting disruptions in language acquisition and help identify clinically useful predictors of PT-related language impairments.

PI_NAMEs: FU, XIAOXUE  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: 37 weeks gestation;Address;Affect;Age;Age Months;Assessment tool;Attention;attentional control;Attentional deficit;Behavior;Behavioral;Birth;Caregivers;Child;Clinical;Complex;Comprehension;Development;Exhibits;experience;extreme prematurity;Frequencies;improved;Individual;Individual Differences;infancy;Infant;innovation;Investigation;joint attention;Knowledge;Laboratories;Language Delays;Language Development;language impairment;language outcome;Life;Live Birth;Longitudinal Studies;Maps;Measures;Motor;motor behavior;motor deficit;Motor Skills;multimodality;multisensory;Names;National Institute of Child Health and Human Development;Neurocognitive Deficit;novel;Parents;Pathway interactions;Performance;Persons;Play;Pregnancy;Premature Birth;preventive intervention;Public Health;Research;research study;Risk;Risk Marker;Role;Shapes;Standardization;Survival Rate;Survivors;sustained attention;Time;Toy;United States;Visual attention;visual motor;visual tracking;word learning

PROJECT_TITLE: Early Predictors of Infant-Parent Coordinated Attention and Word Learning in Preterm and Full-Term Infants

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Public Health Relevance: Sport-related repetitive head impacts (RHI), including soccer heading, are an increasingly recognized public health problem, which have been associated with structural and functional changes typical of brain injury, even in players without history of concussion. The results of our proposed study can expand knowledge by in vivo quantification of cerebral blood flow changes due to RHI and provide insight of into the effect modification by ethnicity, race, handedness, sex, socioeconomic information, and individual histories (occupational, educational, and medical). Our significant step toward a mechanistic understanding of RHI effects can lay a foundation for evidence-based determination of RHI risk among individuals and can facilitate future studies to target mechanisms for prevention and treatment.

PI_NAMEs: LIPTON, MICHAEL LAWRENCE (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Achievement;Administrative Supplement;Area;Brain Concussion;Brain Injuries;career development;Cerebrovascular Circulation;Characteristics;Cognitive;Development;Doctor of Philosophy;Education;Enrollment;Ethnic Origin;evidence base;Exposure to;Fellowship;Foundations;Future;Goals;Handedness;head impact;Human;Impaired cognition;in vivo;Individual;insight;Knowledge;Mediating;Medical;Mentors;Modification;National Institute of Neurological Disorders and Stroke;National Research Service Awards;Neurosciences;novel;Occupational;parent project;Parents;pre-doctoral;Prevention;programs;Public Health;public health relevance;Race;Recording of previous events;Research Project Grants;Risk;Role;sex;Soccer;socioeconomics;Sports;timeline;Training;Training Programs;white matter;Work;Writing

PROJECT_TITLE: Heading and Soccer: Understanding Cognitive Risks, Benefits, and the Potential Mediating Role of White Matter


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: ROCHESTER

ORG_NAME: OAKLAND UNIVERSITY

ORG_STATE: MI

PHR: NARRATIVE Understanding how biological systems function – whether normally or in pathological conditions – is essential for maintaining and improving the public health. Researchers cannot improve current standards and practices of clinical care, or develop new treatment modalities, imaging methods, or pharmaceuticals and pharmaceutical targets, without that understanding. The research we will be able to conduct in a renovated core facility at Oakland University will support just such improvements, in areas ranging from vision to cardiovascular and neuroscience, biomedical imaging, DNA damage and repair, addiction, inflammation, developmental biology, and the effects of cancer treatment.

PI_NAMEs: BANES-BERCELI, AMY  (contact)

PROGRAM_OFFICER_NAME: LI, XIANG-NING

PROJECT_TERMS: addiction;Adenoviruses;aged;Anatomy;animal safety;Applied Research;Area;Basic Science;biocontainment facility;Biological;biological systems;biomedical imaging;Biomedical Research;cancer therapy;Cardiovascular system;Cell Line;clinical care;clinical practice;Colitis;Colon;Core Facility;Decontamination;design;Developmental Biology;DNA Damage;DNA Repair;Electricity;Embryo;Ensure;Equipment;experimental study;Funding;Health;imaging modality;improved;Inflammation;Infrastructure;Institution;instrument;Interruption;Lentivirus;Manufacturer;Mechanics;Medical Waste;Modality;Modeling;Neurosciences;operation;particle;Pathologic;Pharmacologic Substance;Procedures;Process;Public Health;Recombinant DNA;Reproducibility;Research;Research Personnel;Research Support;Resources;Rodent Model;Running;Savings;Secure;Services;Small Intestines;stem cell therapy;stem cells;Sterilization;stool sample;System;Time;Tissue Sample;Transfection;United States National Institutes of Health;Universities;Vertebrates;Vision;Water;Work

PROJECT_TITLE: Replacement of Two Autoclaves for Oakland University's Biomedical Research Support Facility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (91)]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Emergency Care;Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: Portsmouth

ORG_NAME: PIROUETTE MEDICAL

PHR: Project Narrative Background: From 2000 to 2019, opioid overdose deaths in the US increased by 255%; and as of 2023, 136 Americans die every day.[1] Naloxone has significantly decreased opioid mortality with increased usage as a front-line life-saving bridge to emergency help and hospitalization. Naloxone HCl Injection, USP (Naloxone) is a non-addictive opioid antagonist that can be given to any person to rapidly reverses overdose symptoms (i.e., respiratory, and central nervous system depression). Naloxone is readily available across all 50 states, often without a prescription, at relatively low cost, even subsidized in many cases through various non-profit and government entities. Community Need: The community (including those susceptible to overdose, family members, first responders, and passersby) are desperately looking for a solution that increases availability, is simple and intuitive to use, and has the needed effectiveness to save a life. I-Corp will allow for a meaningful interaction between Pirouette and that community (AIM I). Availability: When used, Naloxone reverses 93.5% of opioid overdoses. [2] However, Naloxone is not always on-hand when it is needed. Community saturation through widespread distribution and adoption could avert 21% of opioid overdose deaths.[3] The clear choice in increasing adoption of Naloxone is an auto-injector, but unfortunately, there are currently no OTC Naloxone auto-injectors (NAI) available and the single prescription NAI is only available to first responders (AIM III). Usability: A NIDA study illustrated that Naloxone is often administered by untrained bystanders under extreme stress - which studies show leads to accidents, missed doses and tragic consequences.[3] Existing solutions have usability drawbacks (e.g., failure to deliver full dose, needle stick injuries, etc.) that can lead to a general fear and anxiety around using the devices. Effectiveness: The emergence of synthetic opioids (e.g., fentanyl and carfentanyl), which comprise most of the non-regulated drug market, requires improved efficacy.[5]–[7] Intramuscular (IM) administration shows a marked improvement in efficacy (2X) over intranasal due to the absorption rate and half-life in the patient's system. IM administration also requires less frequent follow-up doses (which may also help with availability). The superiority of IM administration makes it ideal for more rural settings where the opioid epidemic is most prolific.[4] Pirouette’s Solution: Pirouette Medical is developing a novel, low-profile, disc shaped auto-injector that can be used to deliver Naloxone HCl Injection, USP intramuscularly safely and intuitively. Pirouette’s NAI, REZQGO, focuses on affordability, portability, and usability. The intuitive design allows individuals with limited or no training to easily administer an injection to themselves or others. REZQGO has controlled steps to administer a dose rapidly, while minimizing the risk of accidental injections, lacerations, and needle sticks. Pirouette’s NAI aims to reduce the stress and anxiety surrounding injections through a better device, at an affordable price. As part of the Phase I SBIR parent award, Pirouette is rigorously verifying the design and usability of non-GMP prototypes of REZQGO. Based on preliminary research, interview feedback, and FDA guidance, Pirouette is initially pursuing two dose strengths: 2mg/0.4mL and 10mg/0.4mL. The 2mg dose was chosen specifically for a Direct to OTC pathway per the FDA's Overdose Prevention Framework (Docket No. FDA-2022-N-2673). The 10mg dose was selected based on the relevant FDA Product Specific Guidance (PSG# 215457). I-Corp Benefits: Pirouette’s parent award originally proposed a 5mg dose, and we still believe there is an opportunity for a third dose strength in between the currently proposed 2mg (OTC) and 10mg (Rx) doses. Conversations with several Emergency Medical Service (EMS) personnel have confirmed this need for a more potent IM initial dose in the 4-5mg range. Pirouette intends to research product-market fit as part of the I Corps program for this subsequent user need and resulting product (AIM II). To that end, Pirouette selected a diverse team of professionals with experience in project management, emergency management, regulatory, new product introduction, and commercialization. Pirouette has submitted two Pre-IND meeting requests to the FDA, one for the 2mg dose (IND#169211), and one for the 10mg dose (IND# 169426). Pirouette anticipates the meetings to be completed by mid-January 2024. The feedback directly from the FDA will also help inform Pirouette’s research in the I-Corps program to select a third dose in the product lineup, giving users another option in their fight to save lives in the Opioid Public Health Emergency. I-Corps will assist Pirouette in market research, regulatory planning, pricing / reimbursement strategy, usability, and the commercialization / GMP implementation of the REZQGO product lineup.

PI_NAMEs: CULLINANE, CONOR R (contact)

PROGRAM_OFFICER_NAME: KOSTOV, YORDAN VALTCHOV

PROJECT_TERMS: absorption;Accidents;Adoption;American;Anxiety;carfentanil;Central Nervous System;commercialization;Communication;Communities;Contracts;cost;Data;design;design verification;Devices;Dose;drug market;Effectiveness;Emergency medical service;Emergency Situation;Ensure;experience;Failure;Family member;Feedback;Fentanyl;fighting;first responder;follow-up;Fright;Funding;Future;Government;Half-Life;Hand;Harm Reduction;Health Personnel;Health Professional;Hospitalization;Human Resources;improved;Individual;Injections;Innovation Corps;insight;interest;Interview;Intramuscular;Intranasal Administration;Intuition;Journals;Laceration;Life;manufacturing cost;Market Research;Marketing;Measures;Medical;Medicare/Medicaid;meetings;Mental Depression;Mentorship;Naloxone;naloxone dosing;National Institute of Drug Abuse;Needlestick Injuries;novel;Opiate Addiction;Opioid;opioid abuse;Opioid Antagonist;opioid epidemic;opioid mortality;opioid overdose;Overdose;overdose prevention;Overdose reversal;parent project;Parents;Pathway interactions;Patients;Persons;Phase;portability;pre-Investigational New Drug meeting;Predisposition;Price;Privatization;programs;prototype;public health emergency;Research;respiratory;risk minimization;rural setting;Sample Size;Shapes;Small Business Innovation Research Grant;Stress;stress reduction;Surveys;Symptoms;synthetic opioid;System;Training;usability

PROJECT_TITLE: A Rugged, Reliable, Portable, Safe, and Simple Naloxone HCl Auto-Injector forLife-Saving Treatment of Opioid Overdose


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Despite substantial progress in recent years in identifying neural correlates of auditory hallucinations in psychosis, unanswered questions regarding underlying mechanisms have hindered the development of targeted interventions for affected individuals who do not respond adequately to standard treatments. The proposed research will employ cutting-edge electroencephalography (EEG) methods to investigate potential contributions of auditory processing impairments and alterations in the influence of expectations based on prior knowledge to these symptoms with the aim of informing mechanism-based interventions. Given the significant unmet therapeutic need this work aims to address, the proposed study is consistent with the public health mission of the National Institute of Mental Health.

PI_NAMEs: LALOR, EDMUND ;THOMPSON, JUDY LORRAINE (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acoustics;Address;Adverse event;Affect;Antipsychotic Agents;Applications Grants;Auditory;Auditory Hallucination;auditory processing;Biological Markers;Brain;Categories;Computers;Data;Development;Diagnostic;Distress;Electroencephalography;Event;expectation;experience;Exposure to;functional disability;Functional disorder;Goals;Hallucinations;Heterogeneity;Impairment;indexing;Individual;innovation;Intervention;Investigation;Knowledge;Language;lexical;Linguistics;Link;machine learning method;Measures;Methods;Mission;Modeling;National Institute of Mental Health;neural;neural correlate;neurophysiology;new therapeutic target;novel;Participant;Pathologic;Pathology;Perception;Pharmaceutical Preparations;phenomenological models;Phonetics;Play;Process;Psychoses;Psychotic Disorders;Public Health;recruit;Research;Research Domain Criteria;response;Role;Schizophrenia;Sensory;sensory input;Severities;Signal Transduction;Speech;Speech Intelligibility;speech processing;standard care;Stimulus;Strategic Planning;Subgroup;Symptoms;Text;theories;Therapeutic;Therapeutic Intervention;therapeutically effective;Treatment Side Effects;United States National Institutes of Health;Visual Illusions;Visual Perception;Voice;Work

PROJECT_TITLE: Natural Speech Processing, the Influence of Prior Knowledge, and Auditory Hallucinations in Schizophrenia

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Lupus;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Biobehavioral Basis and Outcomes of Cognitive Dysfunction in  Childhood-Systemic Lupus Erythematosus NARRATIVE Cognitive dysfunction is a common central manifestation in childhood-onset systemic lupus erythematosus (cSLE) that remains underdiagnosed and undertreated. Determining the aberrant biological processes and outcomes associated with cognitive dysfunction can improve the treatment and quality of life of patients with cSLE. The proposed work will utilize complementary neuroimaging techniques to characterize abnormal brain function and structure in children with cSLE compared to children with mood disorder (e.g., depression or anxiety) as well as healthy peers, and determine how neurobiological properties relate to cognitive ability and other clinical characteristics (e.g., neuropsychiatric symptoms and lupus disease activity).

PI_NAMEs: CHANG, JOYCE CHUN-LING;UPADHYAY, JAYMIN A (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: 18 year old;Adult;Age;Anisotropy;Anxiety;Anxiety Disorders;Astrocytes;Attenuated;Behavioral;behavioral outcome;biobehavior;Biological;Biological Process;Blood;Blood Vessels;Boston;brain dysfunction;Brief Psychiatric Rating Scale;Central Nervous System;Cerebrospinal Fluid;Characteristics;Child;Childhood;Choline;Clinical;Cognition;cognitive ability;Cognitive deficits;cognitive function;cognitive testing;cohort;comorbidity;Corpus Callosum;cost effective;Data;Data Set;Depressive disorder;Diagnosis;Diffusion Magnetic Resonance Imaging;Digit structure;Disease;Elements;Eligibility Determination;Enrollment;experience;Female;flexibility;Functional disorder;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;glial activation;Glucocorticoids;Goals;gray matter;Health;Health behavior;health related quality of life;hemodynamics;Homeostasis;immune cell infiltrate;Immunologics;Immunology;Impaired cognition;improved;indexing;Inferior;Inflammatory;insight;Investigation;Magnetic Resonance Imaging;male;Measures;Mental Depression;Mental disorders;Methods;Mood Disorders;mood symptom;Morphology;multidisciplinary;myoinositol;Neurobiology;Neurocognitive Deficit;neurodevelopment;neuroimaging;Neuroimmune system;neuroinflammation;neuropsychiatric disorder;neuropsychiatric symptom;Neuropsychiatric Systemic Lupus Erythematosus;neuropsychiatry;Neuropsychology;Neurosciences;neurovascular;novel;Occupational;Optics;Outcome;Parietal Lobe;Pathologic;Pathway interactions;Patients;Pediatric Hospitals;peer;Pharmaceutical Preparations;Phenotype;Population;portability;Predictive Factor;Prefrontal Cortex;Process;programs;Property;prospective;psychiatric symptom;Psychiatry;Psychopathology;psychosocial;Quality of life;Research;Resolution;Rest;Role;Schools;Self Management;Severities;sex;Site;statistics;stressor;Structure;Structure of choroid plexus;System;Systemic Lupus Erythematosus;Techniques;Therapeutic;Toxic effect;white matter;white matter change;Work

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Hematology;Neurosciences;Orphan Drug;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Individuals with sickle cell disease (SCD) develop cognitive and other behavioral abnormalities, which are a major source of disability, including loss of job/unemployment and economic potential. The aim of this proposal is to identify the biological factors involved in the development of these learning and behavioral abnormalities and to potentially advance our understanding of their role in the development of these complication and also whether they could be used as targets of drugs and/or prevention efforts.

PI_NAMEs: HYACINTH, HYACINTH IDU (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Address;Adult;Age;Age of Onset;aged;Agonist;Anemia;Anxiety;Behavioral;Biological Factors;Blood flow;Blood Vessels;Bone Density;Bone Marrow;Brain;Cerebral Infarction;Cerebral Ischemia;cerebral ischemic injury;cerebral microinfarct;Cerebrum;Child;Chronic;Clinical Trials;Cognitive;Cognitive deficits;cognitive function;cohort;Communication;Complication;Cross-Sectional Studies;cytokine;Dendrites;Dendritic Spines;density;design;Development;disability;Drug Targeting;Economics;Educational Status;FDA approved;Genes;Golgi Apparatus;Healthcare;Hippocampus;Histologic;Histology;Image;Immunohistochemistry;improved;in vivo;Individual;Infarction;Inflammation;Inflammatory;Injury;Intelligence quotient;Intervention;Job loss;Knowledge;Laser Scanning Microscopy;Learning;Life;Link;low socioeconomic status;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Mediating;Mediator;Memory;Mental Depression;Microglia;Minocycline;Modeling;Molecular;Morphology;Mus;neuroinflammation;Neuronal Plasticity;neuronal survival;Neurons;neurotrophic factor;Neurotrophic Tyrosine Kinase Receptor Type 2;novel therapeutic intervention;novel therapeutics;Outcome;Pathologic;Pathologic Processes;Patients;Peripheral;Pharmaceutical Preparations;Pilot Projects;pre-clinical;prevent;Prevention;Prevention strategy;prospective;PTPRC gene;Quality of life;Randomized;receptor;Reporting;Research;Research Design;Resources;Role;Severities;Sickle Cell;Sickle Cell Anemia;Signal Transduction;small molecule;Source;Stroke;systemic inflammatory response;Testing;Therapeutic;treatment strategy;two-photon;Unemployment;Vascular Diseases;Vertebral column

PROJECT_TITLE: Minocycline as a potential therapy for neuroinflammation and cognitive deficit in sickle cell disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Psychosis;Schizophrenia;Serious Mental Illness

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PUBLIC HEALTH RELEVANCE The proposed project will study the association between hippocampal-based memory deficits and hippocampal structural alterations in patients with early and chronic schizophrenia. The goal is the development of a marker to improve the understanding of disease progression and neuropathology of schizophrenia.

PI_NAMEs: AVERY, SUZANNE N (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Algorithm Design;Amnesia;Anterior;Binding;brain abnormalities;Brain imaging;Brain Pathology;Brain region;burden of illness;Chronic;Chronic Disease;Chronic Schizophrenia;Clinical;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Collection;cost;Data;Development;Dimensions;Disease;Disease Progression;Early Diagnosis;early psychosis;early screening;Economic Burden;effective therapy;Effectiveness;Event;experience;experimental study;Family;Functional disorder;functional improvement;Goals;Head;Heterogeneity;hippocampal atrophy;Hippocampus;Impairment;improved;Knowledge;life span;Link;Location;Maps;Measurement;Memory;Memory impairment;Mental disorders;Monitor;neural;neuroimaging;neuroimaging marker;neuropathology;Neurophysiology - biologic function;Neuropsychological Tests;novel;novel marker;Onset of illness;Outcome;Participant;Pathology;Patients;Pattern;Performance;personalized predictions;Predictive Value;prevent;progression marker;Protocols documentation;Psychoses;public health relevance;recruit;relational memory;Research;Schizophrenia;segregation;social;Societies;spatial memory;Standardization;Stimulus;Structural defect;Structure;Subgroup;Tail;Testing;treatment response;Triplet Multiple Birth;Work

PROJECT_TITLE: Mapping relational memory deficits and their hippocampal correlates in schizophrenia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative (3 sentences) Public health insurance programs are being implemented across the globe, putting substantial pressure on public finances, despite the fact that there is limited evidence on their causal impact in the long term. This study will address this knowledge gap by utilizing the rollout of Seguro Popular, a nationwide program that provides public health insurance to approximately half of Mexico’s population. By exploiting the panel nature of the Mexican Family Life Survey, the first large-scale, nationally representative survey that has successfully followed respondents across international borders, this project will merge detailed migration histories, rich individual and household health and economic survey questions, and program rollout information to identify and document the extent to which providing universal health insurance in a developing country can improve fetal development, support child health, promote wellness over the life course, and ultimately, reduce existing economic disparities through improved household finances, nutrition, and provision of public health resources.

PI_NAMEs: VELASQUEZ, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Adult;Age;Applications Grants;Behavior;behavioral response;beneficiary;Biological;Biology;burden of illness;Child;Child Health;Child Support;Childhood;Communities;Control Groups;Country;Data;design;Developed Countries;Developing Countries;early childhood;economic disparity;economic outcome;Economics;Education;Effectiveness;Environment;expectation;Expenditure;experience;Exposure to;Family Life Surveys;Fertility;Fetal Development;Financial Hardship;follow-up;Future;Goals;Government Financing;Government Programs;Growth;Health;Health Benefit;health care service utilization;Health Expenditures;Health Insurance;Health Personnel;Health Promotion;Health Resources;Health Services Accessibility;Healthcare;Healthcare Systems;Height;Household;Improve Access;improved;in utero;Individual;Information Distribution;Infrastructure;innovation;insight;intergenerational;International;Investments;Knowledge;late life;Life;Life Cycle Stages;Link;Literature;Long-Term Effects;Longitudinal Surveys;Marketing;Measures;Methods;Mexican;Mexico;Migrant;migration;mortality;Nature;novel;nutrition;Outcome;Personal Satisfaction;physical conditioning;Policies;Population;population health;Poverty;pressure;Program Evaluation;programs;Provider;Public Health;public health insurance;Randomized, Controlled Trials;Recording of previous events;Reduce health disparities;Research;Respondent;Risk;Running;Sampling;Services;Shock;Side;Social Mobility;Speed;success;Surveys;Text;Time;Translating;transmission process;Variant

PROJECT_TITLE: Long-term effects of universal health insurance in developing countries: Evidence from Mexico

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: CARBONDALE

ORG_NAME: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE

ORG_STATE: IL

PHR: Project Narrative Sensorineural hearing loss is a common disease with a prevalence of 20% in the United States, which can impede development of speech and language skills in children and cognitive functions in adults. Stereocilia of inner ear hair cells are organelles that function as biological mechanical switches essential for normal hearing and often degenerate in individuals with sensorineural hearing loss. Single-molecule functional analyses proposed in this study are experimental frameworks to elucidate the molecular dynamics in wild type stereocilia with the goal of identifying therapeutic targets for malfunctioning stereocilia.

PI_NAMEs: MIYOSHI, TAKUSHI  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: Acoustics;Actins;Adult;Affect;Age;Animals;Apical;Area;Award;beta Actin;Binding;Biological;Body System;Brain;candidate identification;career;Cell Physiology;Cells;cellular microvillus;Child;Clinical;cofilin;cognitive function;Comb animal structure;Cryo-electron tomography;Cryoelectron Microscopy;Cultured Cells;Data;deafness;deep learning;Development;Dimensions;Disease;Dissociation;Electron Microscopy;Engineering;experimental study;F-Actin;Family;Fluorescent Dyes;Functional disorder;Future;Genes;Genetic Recombination;genetic regulatory protein;genetic variant;Goals;Gold;Hair Cells;Hearing;hearing impairment;high resolution imaging;Human;Image;in vivo;Individual;inducible gene expression;Inner Hair Cells;Kinetics;Knowledge;Label;Laboratories;Labyrinth;Language;Learning;life span;Light;light microscopy;Lighting;Mechanics;Mentors;Methodology;Methods;Microfilaments;Microscope;Microscopy;Modeling;Molecular;molecular dynamics;monomer;mouse model;Movement;Mus;mutant;Mutant Strains Mice;nanoGold;National Heart, Lung, and Blood Institute;National Institute of Biomedical Imaging and Bioengineering;National Institute on Deafness and Other Communication Disorders;Natural regeneration;Neurons;normal hearing;novel;Organelles;particle;Pathogenicity;Pathology;Pathway interactions;Persons;Phase;Population;Prevalence;Process;Proteins;repaired;Reporting;Research;Research Personnel;Resolution;Sampling;segregation;Sensorineural Hearing Loss;single molecule;single nucleus RNA-sequencing;skills;Speech Development;Stains;Streptavidin;Structure;superresolution microscopy;Surface;Techniques;Technology;therapeutic target;Time;trafficking;Training;transcriptomics;Transgenic Mice;treadmill;United States;United States National Institutes of Health;Visualization

PROJECT_TITLE: Advanced microscope technologies for single-molecule functional analyses of stereocilia components necessary for normal human hearing


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Epilepsy;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: PROJECT NARRATIVE Globally, epilepsy is highest in sub-Saharan Africa, and in Kenya, a vast majority of people with epilepsy do not receive appropriate treatment (epilepsy treatment gap). We will conduct the first cluster-randomized trial in western Kenya to assess the effectiveness of task sharing supported by the epilepsy medical records system in improving access to and retention in care of people with epilepsy and thus epilepsy care outcomes. This research will enhance epilepsy research and clinical capacity by implementing scalable and sustainable strategies to reduce the epilepsy treatment gap in low-resource settings.

PI_NAMEs: ODUOR, CHRISPINE  OWUOR ;VON GAUDECKER, JANE  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Adolescence;Adult;Africa South of the Sahara;age group;American;Anticonvulsants;Behavioral Model;Belief;budget impact;burden of illness;care outcomes;Caring;Cessation of life;Chronic Disease;Clinical;clinical practice;clinical training;Cluster randomized trial;Collaborations;Community Healthcare;contextual factors;cost;Cost Analysis;cost effective;cost effectiveness;cost per quality-adjusted life year;County;culturally appropriate intervention;Data;Development;Disease;Disease Management;effectiveness evaluation;Effectiveness of Interventions;Ensure;Epilepsy;evidence base;Female;follow-up;Future;Goals;Government;group intervention;Health;health care availability;Health Care Costs;Health care facility;health care service utilization;Health Personnel;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Home;Improve Access;improved;incremental cost-effectiveness;Indiana;Infrastructure;Injury;innovation;interest;Intervention;Kenya;Life;life span;Mediating;Mediator;Medical Records;medication compliance;medication nonadherence;Mentors;Mentorship;Modeling;Morbidity - disease rate;mortality;Neurologic;Newly Diagnosed;Participant;Patients;Pattern;Persons;Policy Developments;Positioning Attribute;premature;Prevalence;primary outcome;programs;Public Hospitals;Public Sector;Quality of life;Random Allocation;Recommendation;Research;Research Personnel;Resource-limited setting;Resources;Risk;Rural;Seizures;Severities;sex;social stigma;stakeholder perspectives;System;Testing;therapy design;Training;Transportation;Travel;treatment as usual;Treatment Cost;Treatment outcome;trial comparing;Universities;willingness to pay;Work;World Health Organization;young adult

PROJECT_TITLE: Bridging the Treatment Gap by Expanding Access to Care for People with Epilepsy in Kenya (BEACON)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-L (55)]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Cancer;Clinical Research;Networking and Information Technology R&D (NITRD);Prostate Cancer;Urologic Diseases

ORG_CITY: CHAPPAQUA

ORG_NAME: VIZLITICS INC.

PHR: Narrative Prostate cancer is the leading cancer diagnosis in men (not including skin cancer) and has high survival rates (98% at 5 years), resulting in an estimated 3.2M US men currently living with prostate cancer. However, data shows follow up among prostate cancer patients remains a significant challenge. This project will create a cloud- based clinical decision support system to automatically monitor, track, and optimally classify prostate cancer cases for triage by applying advanced algorithms to curated medical data.

PI_NAMEs: HENSLEY ALFORD, SHARON  (contact)

PROGRAM_OFFICER_NAME: WEBER, PATRICIA A

PROJECT_TERMS: active method;Address;Aftercare;Algorithms;Cancer Center;cancer diagnosis;Cancer Patient;Caring;Classification;Clinic;Clinical;Clinical Decision Support Systems;cloud based;Collaborations;commercialization;Communities;Computer Models;Cost Savings;dashboard;Data;Electronics;follow-up;Future;Guidelines;Health Services Accessibility;improved;individual patient;Ingestion;insight;Knowledge;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Marketing;Medical;Medical Records;men;Modeling;Monitor;novel;Oncologist;patient health information;patient population;Patient Preferences;Patient-Focused Outcomes;Patients;Persons;Phase;Physicians;pilot test;Preparation;Probability;Process;Protocols documentation;Provider;Publishing;Recommendation;Research;Resources;Running;Skin Cancer;software as a service;Survival Rate;Testing;Time;tool;Triage;usability;virtual;Visit;Woman

PROJECT_TITLE: VIPCare: A cancer patient surveillance platform that runs clinical workflow for identifying, tracking, evaluating and engaging cancer surveillance cases.


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE This Diversity Supplement to the Healthy Brain and Child Development (HBCD) study will examine the influence of transgenerational supplement development infant programming an career  experiencing discrimination on mental health during the peripartum period and determine the potential  influence of discrimination by examining offspring neurobehavioral development. This  provides a talented clinical psychology graduate student with unique opportunities for career through interactions with he network of HBCD i nvestigators, training in methods for characterizing behavior and brain development, and immersion in key theoretical and methodological aspects of prenatal  research, including assessment of perinatal mental health and social determinants of health with  emphasis on discrimination. These training experiences will position the applicant to reach her long-term goal to pursue a career in research t investigating the mechanisms by which social-emotional adversity transmits intergenerationally, and influences child behavior, affect and development.

PI_NAMEs: GRAHAM, ALICE M;SULLIVAN, ELINOR L. (contact)

PROGRAM_OFFICER_NAME: PRABHAKAR, JANANI

PROJECT_TERMS: Affect;Age Months;Amygdaloid structure;Animal Model;Area;Behavior;Behavioral;biological systems;Brain;career;career development;Child;Child Behavior;Child Development;Clinical Psychology;Code;Country;Data;Development;Diagnostic;Discrimination;Emotional;Environment;equity, diversity, and inclusion;experience;fetal;Goals;graduate student;Grant;Health;health determinants;Helping to End Addiction Long-term;high risk population;Human;Immersion;improved;infancy;Infant;Infant Behavior;Infant Development;Institution;intergenerational;International;Lead;Magnetic Resonance Imaging;Manuscripts;Mental Health;Mentorship;Methodology;Methods;negative affect;neurobehavioral;offspring;Opiate Addiction;Opioid;opioid misuse;Outcome;perceived discrimination;Perinatal;perinatal mental health;Phenotype;Play;Policies;Positioning Attribute;prenatal;prenatal exposure;protective factors;Public Health;Public Policy;Research;Research Personnel;Risk;Risk Factors;Role;skills;social;social health determinants;Speed;statistics;Stress;Symptoms;Talents;Testing;Training;transmission process;United States National Institutes of Health;Work;working group;Writing

PROJECT_TITLE: The Transgenerational Influence of Discrimination on Mental Health

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(51)-R]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Digestive Diseases;Genetics;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE This proposal investigates the role of a CDH-associated gene, ZFHX4, in the fetal lung. The findings will provide insight into the pathogenesis of lung hypoplasia in CDH and inform mechanisms of lung mesenchymal cell differentiation.

PI_NAMEs: AI, XINGBIN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Alleles;Alveolar;Animal Model;Antibodies;Binding;Binding Proteins;Biological Assay;Birth;Brain Stem;CDH1 gene;Cell Differentiation process;Cell Separation;cell type;Cells;Chromatin;chromatin immunoprecipitation;Cleft Palate;Clinical;cohort;Collaborations;Congenital diaphragmatic hernia;Defect;Detection;Development;differential expression;Disparity;Embryo;Embryonic Development;Environmental Risk Factor;Epigenetic Process;Etiology;Event;Exhibits;Fetal Lung;Fibroblasts;Funding Mechanisms;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;genomic locus;Goals;Homeobox;Hour;Human;Immunoprecipitation;Impairment;insight;Investigation;Kinetics;Lung;lung development;Maps;Mass Spectrum Analysis;Mediator;Medical;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Messenger RNA;Modeling;Morbidity - disease rate;Morphogenesis;mortality;Mus;Nature;nerve supply;Newborn Infant;Operative Surgical Procedures;Organ;Pathogenesis;Pathway interactions;Patients;Pattern;Perinatal mortality demographics;Phenotype;Platelet-Derived Growth Factor alpha Receptor;progenitor;programs;Proteins;Proteomics;pulmonary hypoplasia;recruit;Regulation;Regulator Genes;repaired;Respiratory Diaphragm;respiratory smooth muscle;Role;selective expression;Site;Specific qualifier value;Specificity;Testing;The Jackson Laboratory;Therapeutic;Tissues;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;transcriptomic profiling;Validation;Variant;Viscera;Zinc Fingers

PROJECT_TITLE: ZFHX4 sets alveolar fibroblast differentiation potential of mesenchymal progenitors in the fetal lung

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Dissemination and Implementation Research;Recovery Support Services;Substance Misuse

ORG_CITY: SOLON

ORG_NAME: THRIVE DIGITAL HEALTH, LLC

PHR: PROJECT NARRATIVE Thrive Digital Health (TDH) is developing and testing a novel technology platform to enhance, standardize and scale the training of the Peer Recovery Supporter workforce. Peer Recovery Support Services are being increasingly implemented across the U.S. as a strategy to fill care gaps, and this platform will enable public and private organizations to efficiently and cost-effectively build their PRSS workforce, and support that workforce on an ongoing basis as they serve individuals recovering from alcohol and other substance use disorders. Over time, the innovations resulting from this project will significantly reduce costs for individuals, public and private payers, the healthcare system, and society at large.

PI_NAMEs: PESCE, CHRISTOPHER NEIL (contact)

PROGRAM_OFFICER_NAME: HAGMAN, BRETT THOMAS

PROJECT_TERMS: Address;Adherence;Alcohols;Caring;cost;Country;Critical Care;Development;digital health;evidence base;Goals;Health;Health Personnel;Healthcare Systems;implementation fidelity;Individual;innovation;Knowledge;Marketing;new technology;novel;peer recovery;peer support;Phase;Population;Privatization;Provider;recovery services;skills;Societies;Standardization;stem;Substance Use Disorder;success;technology platform;Teleconferences;Testing;Time;Training;treatment services;usability

PROJECT_TITLE: DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM TO DISSEMINATE EVIDENCE-BASED TRAINING AT SCALE - I-CORPS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Aphasia;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Rehabilitation;Stroke

ORG_CITY: CHICAGO

ORG_NAME: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB

PHR: The proposed study focuses on using multi-modal assessments (assessed through eye- tracking, pupil dilation, and resting-state heart rate variability) to identify depression, a psychiatric condition characterized by chronically low mood, in persons with aphasia. Results will contribute to new evidence regarding the validity, reliability and reproducibility of using these measures to accurately assess depression in persons with aphasia. An accurate depression diagnosis in persons with aphasia can lead to better management of symptoms which can positively impact linguistic, cognitive, and functional outcomes.

PI_NAMEs: ASHAIE, SAMEER AFZAL (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: accurate diagnosis;Adopted;Affect;Affective;Alzheimer's Disease;Aphasia;aphasia rehabilitation;attentional bias;Biological Markers;Caregivers;Chronic;Clinical;Cognitive;cognitive function;cognitive performance;Data;Depressed mood;depressive symptoms;Diagnosis;Diagnostic;Diagnostic tests;diagnostic tool;Disease;Ensure;experience;Face;Family member;Foundations;functional improvement;functional outcomes;Future;gaze;Gestures;Goals;Happiness;heart rate variability;high risk;Home;Image;Impairment;improved;Individual;individual variation;informant;instrument;Interview;Laboratories;Language;Left;Life;Linguistics;Malignant Neoplasms;Measures;Mental Depression;Methodological Studies;Methodology;Methods;Moods;mortality;multimodality;Mydriasis;negative affect;Negative Valence;Neurologic;novel;Outcome;outcome prediction;Parkinson Disease;Patients;Persons;pleasure;Positive Valence;predictive marker;Proxy;Quality of life;Questionnaires;Reading;Recommendation;Recording of previous events;Recurrence;Reference Standards;Rehabilitation therapy;Reporting;Reproducibility;Rest;Sampling;self-reported depression;Severities;Social Interaction;Stroke;stroke risk;stroke survivor;symptom management;Symptoms;systematic review;Testing;Time;Treatment outcome;treatment response;Validity and Reliability;verbal;visual tracking;Work;Writing

PROJECT_TITLE: Validating non-linguistic laboratory biomarkers of depression in persons with aphasia

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Nanotechnology;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Glioblastoma multiforme (GBM) is a malignant primary brain cancer which carries a dismal prognosis. STAT3 has been shown to be a very attractive therapeutic target for GBM; albeit, small molecule inhibitors of STAT3 signaling are ineffective, as they exhibit very poor blood brain barrier permeability. Our interdisciplinary team will develop and evaluate a novel and scalable bi-compartmental nanoparticle delivery system that allows controlled co-release of STAT3 siRNA and the chemotherapeutic agent, paclitaxel. This work may result in a new treatment modality for GBM, a tumor type, for which no effective treatments exist.

PI_NAMEs: CASTRO, MARIA G;LAHANN, JOERG  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Accounting;Adjuvant Chemotherapy;Albumins;Blood - brain barrier anatomy;blood-brain barrier permeabilization;Brain;Brain Neoplasms;Cancer Patient;chemotherapeutic agent;Data;design;Drug Delivery Systems;effective therapy;Encapsulated;Excision;Exhibits;experimental study;Glioblastoma;Glioma;Goals;Growth;Human;improved;inhibitor;Intracranial Neoplasms;Malignant - descriptor;Malignant neoplasm of brain;Medial;Modality;Mus;nanoparticle;nanoparticle delivery;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Paclitaxel;Patients;Penetration;Peptides;Pharmaceutical Preparations;Phase I Clinical Trials;Prognosis;Radiation therapy;Serum Albumin;side effect;Signal Transduction;Signaling Molecule;Small Interfering RNA;small molecule;small molecule inhibitor;standard of care;System;targeted delivery;temozolomide;Testing;Therapeutic;therapeutic target;Transcription Factor 3;Transducers;Translating;tumor;Work

PROJECT_TITLE: Systemic Delivery of Targeted Bi-Compartmental Nanoparticles for Glioblastoma Therapeutics (Supplement)


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: BERKELEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: Project Narrative The coordinated firing of millions of neurons in the human brain gives rise to the diverse set of experiences, emotions, thoughts, and sensations that make up the human condition. Despite the central importance of neuronal physiology to human health and disease, our understanding of this complex field remains incomplete due to a lack of tools that can reliably report on membrane potential. This proposed research will develop and apply new optical tools to study neuronal membrane potential in cells and in circuits.

PI_NAMEs: MILLER, EVAN WALKER (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Interrogating Neuronal Membrane Potential Dynamics with Optical Voltage Sensors

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Regenerative Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE Axolotl salamanders are powerful experimental models for exploring a variety of important biomedical questions, yet they require specialized aquatic facilities and equipment for housing to enable rigorous and reproducible research. This proposal will support a shared-use aquatics facility for axolotl used for biomedically-relevant research, including research directed at understanding natural vertebrate limb regeneration. The proposed equipment will directly enable more efficient and reproducible husbandry workflows to raise axolotls for experimentation and for establishment of genome-edited and transgenic lines.

PI_NAMEs: WHITED, JESSICA L. (contact)

PROJECT_TERMS: Address;Adolescent;Adult;Alleles;Ambystoma;American;Amputation;Amputees;Anatomy;Animal Experimentation;Animal Experiments;Animals;appendage;Artemia;Automation;base;Biological;Biological Models;Biology;Breeding;Cannibalism;Cells;Central Nervous System;Developmental Biology;Diabetes Mellitus;Disease;Drosophila genus;egg;Embryonic Development;Ensure;Environment;Equipment;Evolution;Experimental Models;experimental study;feeding;Fingers;Food;Funding;Future;Generations;Genes;Genetic;Genetic Models;genome editing;genome resource;Genomics;hatching;Housing;Human;improved;Individual;Infrastructure;Injury;insight;Instruction;Intervention;Invaded;Knock-out;Laboratories;Laboratory Study;Larva;Learning;Leg;Life;life history;limb amputation;limb regeneration;Limb structure;Malignant Neoplasms;Mammals;Measures;Metabolic;model organism;Modeling;Modernization;Molecular;Morphology;Mus;Natural regeneration;Nature;novel;Organism;pain sensation;Pathway interactions;Patients;Pelvis;Prevalence;Process;programs;Prosthesis;Proteins;regenerative;regenerative biology;Regenerative capacity;Regenerative Medicine;Regenerative research;Renaissance;Reporter Genes;Reproducibility;Reproducibility of Results;Request for Proposals;Research;Research Personnel;Resources;response;Risk;Salamander;Sensory;Side;skeletal;Source;Standardization;stem cells;Stress;System;Tetrapoda;Therapeutic;Time;tool;trait;Transgenic Organisms;Translations;Trees;Water;water quality;Work;Workload;Zebrafish

PROJECT_TITLE: Automated aquatic husbandry equipment to enable rigorous and reproducible axolotl studies


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Research is needed to develop effective responses to the HIV epidemic in sub-Saharan Africa. This grant will allow US scientists to build partnerships with their counterparts in Ghana to train young and emerging scientists to conduct meaningful research in HIV-associated comorbidities (one of the five research priorities of the NIH Office of AIDS Research) spanning basic science, translational, clinical, epidemiology and behavioral research. The program described in this application contains a mix of long-, medium-, and short-term training that will enhance research capacity and promote public health significant research in HIV-associated comorbidities.

PI_NAMEs: PAINTSIL, ELIJAH  (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Biomedical Research;career;career development;Clinical;co-infection;cohort;Communities;comorbidity;design;Doctor of Philosophy;Educational workshop;Enrollment;experience;Exposure to;Faculty;Foundations;Funding;Funding Opportunities;Ghana;graduate student;Grant;Health;Health Services;HIV;Institution;Instruction;Interdisciplinary Study;interest;Knowledge;Laboratories;Leadership;low and middle-income countries;Mentors;Mentorship;multidisciplinary;Needs Assessment;Postdoctoral Fellow;programs;Publishing;recruit;Research;research and development;Research Design;Research Methodology;Research Personnel;research study;Research Training;Resources;Scholars Program;Science;Scientist;Site;skills;Techniques;tool;Training;Training Programs;Universities;Writing

PROJECT_TITLE: HIV Co-morbidities Research Training in Ghana (HIV-ComRT)


NIH_SPENDING_CATS: Brain Disorders;Data Science;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Precision Medicine;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Trials for the treatment of psychiatric and substance use disorders can be difficult, time-consuming, and expensive to conduct, and partially as a consequence, have sample sizes that may be underpowered for: 1) detecting moderately sized average treatment effects (ATEs) that may nonetheless be important for health at the population level, and 2) learning optimal individualized treatment rules (i.e., rules that match treatments to individuals based on demographic and clinical characteristics that optimize outcomes of interest), which are the cornerstone of personalized medicine. Data fusion is a relatively new and increasingly popular domain of data science that combines data from multiple studies to improve statistical power and answer questions that cannot be addressed by a single study alone. Our overall objective is to develop methods that harness follow-up and other post-exposure measurements as potential proxies for outcomes that are systematically missing by study to deliver more precise estimates of causal treatment effects and facilitating the learning of treatment rules that maximize benefits and reduce harms.

PI_NAMEs: MILES, CALEB HILLIARD (contact);RUDOLPH, KARA ELIZABETH

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;Characteristics;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Network;comparative effectiveness trial;Computer software;Consumption;Data;data fusion;data harmonization;Data Science;Data Set;Disease;Drug Use Disorder;Educational workshop;Enrollment;Evidence Based Medicine;expectation;flexibility;follow-up;Goals;Harm Reduction;Health;Heterogeneity;improved;Individual;individual patient;individualized medicine;interest;Learning;Left;Literature;Measurement;Measures;Methods;Modeling;National Institute of Drug Abuse;online tutorial;open source;opioid use disorder;optimal treatments;Outcome;Outcome Measure;Participant;Patients;personalized medicine;Pharmaceutical Preparations;Population;Proxy;Psychiatric therapeutic procedure;Public Health Practice;randomized, clinical trials;Research Personnel;Sample Size;semiparametric;Substance Use Disorder;success;surrogacy;theories;Time;treatment effect;treatment strategy;user friendly software

PROJECT_TITLE: Leveraging harmonized data to improve external validity and efficiency of clinical trials for treating opioid use disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 LXF-E (M1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Training a talented research workforce focused on kidney, benign genitourinary tract, and benign hematological diseases is fundamental to addressing the personal and socio-economic burdens associated with these diseases. Toward this end, we will create a comprehensive training program in Philadelphia that encompasses research training in science related to nephrology, urology, and hematology across the lifespan entitled the Philadelphia Program for Mentored Research Training in Kidney, Urologic, and Hematologic Diseases (PERFORM-KUH).

PI_NAMEs: HOLZMAN, LAWRENCE B. (contact);TONG, WEI

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Academia;Address;Area;Benign;Biomedical Research;career;Career Choice;Clinical Research;Collaborations;Communication;Creativeness;Dedications;Development;Disease;Doctor of Philosophy;doctoral student;Economic Burden;Educational process of instructing;Ensure;Environment;equity, diversity, and inclusion;Evaluation;Faculty;Feedback;Fostering;Goals;Growth;Hematological Disease;Hematology;high school;improved;Industry;Institution;interest;Kidney;Kidney Diseases;life span;medical schools;Medicine;Mentors;Methodology;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;Pediatric Hospitals;peer;peer networks;Pennsylvania;Philadelphia;Population Heterogeneity;Postdoctoral Fellow;pre-doctoral;Process;programs;recruit;Research;Research Institute;Research Personnel;Research Training;Resources;Schools;Science;Scientist;skills;socioeconomics;Structure;Students;Talents;TNFSF15 gene;Training;training opportunity;Training Programs;Translational Research;undergraduate student;Universities;Urogenital Diseases;urogenital tract;urologic;Urologic Diseases;Urology

PROJECT_TITLE: The Philadelphia Program for Mentored Research Training in Kidney, Urologic, and Hematologic Diseases (PERFORM-KUH U2C/Tl1)

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-3 (M1)]


NIH_SPENDING_CATS: Hematology;Kidney Disease;Pediatric;Social Determinants of Health;Urologic Diseases

PI_NAMEs: HOLZMAN, LAWRENCE B. (contact)

PROJECT_TERMS: Address;Admission activity;Benign;Communication;Communities;Development;Disease;Economic Burden;Education;Elements;Ensure;Evaluation;faculty mentor;Feedback;Fellowship Program;Fox Chase Cancer Center;Geography;Hematological Disease;Hematology;improved;innovation;Kidney;Kidney Diseases;Leadership;Learning;life span;meetings;Mentors;Methods;Nephrology;Occupational activity of managing finances;Pediatric Hospitals;Pennsylvania;Philadelphia;Process;programs;recruit;Reporting;Research;Research Training;Science;socioeconomics;System;Talents;TNFSF15 gene;Training;Training Programs;Universities;urogenital tract;Urologic Diseases;Urology;web site

PROJECT_TITLE: Administration Core


PI_NAMEs: KLEIN, PETER S (contact)

PROJECT_TITLE: Professional Development


NIH_SPENDING_CATS: Behavioral and Social Science;Hematology;Kidney Disease;Social Determinants of Health;Urologic Diseases

PI_NAMEs: DENBURG, MICHELLE  (contact)

PROJECT_TERMS: academic preparation;Area;Benign;Biomedical Research;career;Career Choice;Childhood;Clinical;clinical conference;Collaborations;college;Communication;Communities;community building;Education;Education and Outreach;equity, diversity, and inclusion;Event;experience;Exposure to;Faculty;faculty mentor;faculty research;Fostering;Genitourinary system;graduate student;hands on research;Hematological Disease;Hematology;High School Student;Individual;Infrastructure;Institution;interest;Internships;Kidney;Kidney Diseases;Leadership;Low income;medical schools;Medical Students;Medicine;Mentors;Mentorship;Minority-Serving Institution;Nephrology;outreach;outreach program;Participant;peer;peer coaching;Persons;Philadelphia;Population;Positioning Attribute;Postdoctoral Fellow;posters;pre-doctoral;Preparation;programs;recruit;Research;Research Project Grants;Research Training;Resources;responsible research conduct;Role;role model;Scholars Program;Science;senior faculty;social;Societies;STEM career;student mentoring;Students;summer internship;synergism;Time;TNFSF15 gene;tool;Training;Training Activity;training opportunity;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;United States;Universities;urologic;Urologic Diseases;Urology;virtual

PROJECT_TITLE: Networking Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Primary Health Care;Social Determinants of Health

ORG_DEPT: DENTISTRY

PHR: PROJECT NARRATIVE Dental caries is a preventable disease, however, it still affects large numbers of people globally and in the US. Data from the US National Health and Nutrition Examination Survey 2011-2016 cycle found 1 in 4 adults ages 20-64 years had untreated tooth decay. The purpose of this study is to examine whether teeth that were treated with silver diamine fluoride to arrest a carious lesion required subsequent caries-related extraction, root canal therapy or direct/indirect restoration during the 1-5-year follow-up period.

PI_NAMEs: JURASIC, MARIANNE  (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: Address;Adult;Affect;Age;American Dental Association;Ammonia;Appointment;Black Populations;burden of illness;Caries prevention;Caring;Child;Childhood;Clinical effectiveness;Clinical Practice Guideline;Code;Communities;comorbidity;Computerized Medical Record;cost;cost effective;cost outcomes;Country;Data;Data Analyses;deciduous tooth;Dental;Dental Care;Dental caries;Dental Clinics;Dental General Practice;Dental Records;Dentistry;Dentists;Development;Diagnostic;Diamines;Disease;Effectiveness;effectiveness study;Elderly;Electronics;Ethnic Origin;evidence base;federal poverty level;Female;Fluorides;follow-up;Future;health inequalities;Healthcare;Hypersensitivity;improved;Income;Individual;Integrated Health Care Systems;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Japan;Lesion;Location;male;Medical;Medical Device;Medical Records;Methodology;Methods;Mexican Americans;Mouth Diseases;National Health and Nutrition Examination Survey;National Institute of Dental and Craniofacial Research;Not Hispanic or Latino;off-label use;older adult;Oral cavity;Oral health;Outcome;Outpatients;Patients;permanent tooth;Persons;Pharmaceutical Preparations;Population;Poverty;Prevalence;prevent;Prevention;prevention service;Preventive dental care;Primary Prevention;Process;Prospective Studies;Provider;Race;Randomized, Controlled Trials;Recommendation;Research Project Grants;restoration;Root Canal Therapy;Root Caries;Sample Size;Secondary Prevention;Silver;Standardization;statistics;Surface;Surveys;Survival Analysis;systematic review;Time;Tooth Extraction;Tooth structure;tooth surface;Translating;United States;United States Food and Drug Administration;Variant;Veterans;Veterans Health Administration

PROJECT_TITLE: Survival analysis of teeth treated with SDF to arrest caries in adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 CC (13)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Neurosciences;Patient Safety;Prevention;Stroke

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: NARRATIVE Our objective for this research is to determine the efficacy and safety of cilostazol (a novel blood thinner) added to standard therapy compared with standard of care therapies in reducing recurrent strokes, heart attacks and cardiac deaths among recent Ghanaian ischemic stroke or transient ischemic attack survivors over 24 months. Participants in this trial will be enrolled from 12 hospitals including primary, district/regional, and tertiary levels across 6 regions (states) in Ghana to broadly capture patient and clinician experiences with the cilostazol and enhance the generalization of study findings. We also seek to develop an implementation strategy using a consultative, multi-stake holder engagement for routine integration and policy adoption of cilostazol as a safe, cost-effective, approach for post-stroke cardiovascular risk reduction in a resource-limited setting while building clinical trial research capacity in Africa.

PI_NAMEs: OVBIAGELE, BRUCE  (contact);SARFO, FRED STEPHEN

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Adoption;adverse outcome;Africa;Africa South of the Sahara;African;Age;Anticoagulants;Asian population;Aspirin;Awareness;Blood Platelets;Blood Vessels;Cardiac;Cardiac Death;cardiovascular risk factor;Cardiovascular system;Cessation of life;Cilostazol;Clinical;Clinical Trials;clopidogrel;Collaborations;Competence;cost;cost effective;Data;Death Rate;Double-Blind Method;Economics;efficacious treatment;efficacy evaluation;Enrollment;European;Event;evidence base;experience;follow-up;Formulation;Funding;Funding Agency;Ghana;Goals;Guidelines;Health system;Hemorrhage;high risk;high risk population;Hospitals;Human;Hybrids;implementation barriers;implementation cost;implementation evaluation;implementation facilitators;implementation framework;implementation outcomes;implementation strategy;Incidence;inhibitor;International;Investments;Ischemia;Ischemic Stroke;Japanese;Longterm Follow-up;Measures;Mentorship;Minor;mortality;Myocardial Infarction;National Institute of Neurological Disorders and Stroke;Neurocognitive;Neurosciences Research;novel;Outcome;Parents;Participant;participant enrollment;Patients;Pharmaceutical Preparations;phosphoric diester hydrolase;Placebos;pleiotropism;Policies;Population;post stroke;Prevalence;Prevention;primary endpoint;Public Health;Quality of life;randomized, clinical trials;Recording of previous events;recruit;Recurrence;recurrence prevention;Research;Research Design;Research Personnel;Resource-limited setting;Resources;Risk;Risk Reduction;routine care;Safety;secondary outcome;Secondary Prevention;Serious Adverse Event;standard of care;Standardization;Stroke;stroke incidence;stroke outcome;stroke patient;Stroke prevention;stroke risk;stroke survivor;stroke trials;survival outcome;Survivors;System;Testing;Transient Ischemic Attack;uptake;World Health Organization

PROJECT_TITLE: CiLostAzol for pReventIon of recurrent sTroke in Africa (CLARITY-Africa)


NIH_SPENDING_CATS: Cancer;Immunotherapy

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project narrative We propose to expand on IDEA 1 of the parent R35 grant: Use of a multipronged proteomic and genomic approach to define unique and common MYC-driven programs and pathways. Our previous data indicates that experimental inactivation of MYC induces an anti-tumor antibody response. We propose to mechanistically investigate whether MYC mediates its effects on B-cell antibody responses by altering B-cell specific MHC II antigen processing and presentation.

PI_NAMEs: FELSHER, DEAN W (contact)

PROGRAM_OFFICER_NAME: GHOSH-JANJIGIAN, SHARMISTHA

PROJECT_TERMS: Acute;adaptive immune response;Address;Affect;Anatomy;anti-cancer;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigen-Presenting Cells;Antigens;Apoptosis;Area;B-Lymphocytes;Binding;c-myc Proto-Oncogenes;Cancer Etiology;cancer therapy;CD4 Positive T Lymphocytes;Cell Death;Cell Lineage;Cell Maturation;Data;Dental Pulp;derepression;Development;Disease Progression;Disease regression;disorder control;Doxycycline;FDA approved;Future;Genes;Genomic approach;glycosylation;Grant;Hematologic Neoplasms;Human;human model;Immune Evasion;Immune response;Immune system;Immunity;immunogenicity;Immunoglobulin G;In Vitro;Infiltration;innate immune mechanisms;Innate Immune Response;insight;Interferons;Laboratories;Lymphoblastic Lymphoma;Macrophage;Malignant Neoplasms;Mediating;MHC Class II Genes;Modeling;mouse model;Mus;MYC gene;Natural Killer Cells;neoplastic cell;Parents;Pathway interactions;Pattern;Peptides;Pharmaceutical Preparations;Process;Prognosis;programs;promoter;Proteomics;Research;response;Role;Serum;Signal Transduction;Spleen;T-Lymphocyte;targeted treatment;Tetracyclines;therapy development;Transgenic Mice;tumor;Tumor Antibodies;Tumor Antigens;Tumor Immunity

PROJECT_TITLE: Targeting the MYC Pathway for the Treatment of Cancer