NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Radiation Oncology;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: RICE UNIVERSITY

PI_NAMEs: FULLER, CLIFTON DAVID;SCHAEFER, ANDREW J (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Address;Adoption;advanced analytics;Affect;Aging;Algorithms;Anatomy;Area;base;Behavior;Cancer Control;cancer radiation therapy;Capital;chemoradiation;Clinical;Clinical Data;clinical implementation;Clinical Treatment;Communities;Community Hospitals;Complication;Computer software;connected health;cost;Coupled;Data;Data Set;Decision Making;Decision Support Systems;design;Development;Devices;Diagnosis;Dose;Economics;Emerging Technologies;Environment;Equipment;Evaluation;evidence base;Evolution;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Health;Health Policy;Health Technology;Healthcare;Human;Human Resources;Image;image guided radiation therapy;improved;in silico;Incentives;Individual;individual patient;individualized medicine;innovation;insight;Instruction;Insurance Carriers;Life;Linear Accelerator Radiotherapy Systems;low and middle-income countries;Magnetic Resonance Imaging;malignant mouth neoplasm;Malignant neoplasm of larynx;Malignant neoplasm of pharynx;Malignant Neoplasms;Medical Device;Medicare;Methodology;Methods;Modeling;models and simulation;Modernization;Monitor;Morbidity - disease rate;multidisciplinary;Neck Cancer;new technology;next generation;Normal tissue morphology;novel;Operations Research;Organ;Outcome;Overdose;Patient Care;Patient imaging;Patients;Physicians;Policies;Probability;Process;programs;Property;prototype;Provider;Radiation;Radiation therapy;radiation-induced injury;Regimen;Research;Resources;response;Risk;risk stratification;Schedule;Science;Self-Help Devices;Series;side effect;SMART health;soft tissue;Software Tools;standard care;Structure;support tools;Survivors;System;Systems Integration;Techniques;Technology;technology intervention;theories;Time;tool;Toxic effect;treatment planning;treatment response;treatment stratification;tumor;Tumor Volume;Uncertain Risk;Uncertainty;Validation;Variant;Work

PROJECT_TITLE: SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MOSS-V(50)]


ADMINISTERING_IC: OD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTERAGENCY AGREEMENTS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Neurosciences

PROJECT_TERMS: Acute;Address;Affect;age difference;animal model development;Anticonvulsants;Biochemical;carboxylesterase;chemical countermeasure;chemical threat;Chemicals;Chronic;Collaborations;design;Development;efficacy study;efficacy testing;Electrons;Environment;Evaluation;Exposure to;fluorophosphate;Funding;Gene Modified;Genomics;Hospitals;Human;Hydrazines;In Vitro;in vivo;Injury;inorganic phosphate;Investigation;medical countermeasure;Microscopic;Modeling;Molecular;Monomethylhydrazine;Morbidity - disease rate;mortality;mouse model;Mus;National Institute of Allergy and Infectious Disease;Nervous System;Neuropathy;Neuroprotective Agents;neurotoxic;novel;Organophosphates;Paraoxon;Pharmaceutical Preparations;Physiological;Plasma;Poison;Poisoning;Population;Pregnancy;Rattus;Research;research and development;response;Route;Sarin;screening;Security;Seizures;Sex Differences;Soman;therapeutic evaluation;Time;Toxic effect;toxic organophosphate insecticide exposure;Toxicology;United States National Institutes of Health

PROJECT_TITLE: Chemical Countermeasures Collaboration: Chemical Threats Affecting the Nervous System


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Biotechnology;Lung;Opioids;Orphan Drug;Physical Injury - Accidents and Adverse Effects;Rare Diseases

ORG_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PROJECT_TERMS: Acetylfentanyl;Acute;Acute Respiratory Distress Syndrome;Address;Aerosols;Affect;African Green Monkey;animal model development;antagonist;Biochemical;carfentanil;chemical countermeasure;chemical threat;Chemicals;Chronic;Collaborations;Continuous Positive Airway Pressure;design;Development;efficacy study;efficacy testing;Electrons;Environment;Evaluation;Exposure to;FDA approved;Funding;Genomics;Hospitals;Human;in silico;In Vitro;in vivo;Inhalation;Injury;Kinetics;Lung;medical countermeasure;Microscopic;model development;Modeling;Molecular;Morbidity - disease rate;mortality;Mustard Gas;National Institute of Allergy and Infectious Disease;Opioid Antagonist;Pharmaceutical Preparations;Phosgene;Physiological;Poison;Poisoning;Population;Powder dose form;Research;research and development;respiratory;Route;screening;Security;synthetic opioid;System;Therapeutic;Time;Toxic effect;Toxicology;Treatment Efficacy;United States National Institutes of Health

PROJECT_TITLE: Chemical Countermeasures Collaboration: Chemical Threats Affecting the Respiratory/Pulmonary System


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology

PROJECT_TERMS: 2,4-Dinitrophenol;Acrylonitrile;Acute;Address;Affect;animal model development;Biochemical;Cell Respiration;cellular targeting;chemical countermeasure;chemical threat;Chemicals;Chronic;Collaborations;Cyanides;Cyclodextrins;design;Development;efficacy study;efficacy testing;Electrons;Environment;Evaluation;Exposure to;Funding;Genomics;Hospitals;Human;in silico;In Vitro;in vivo;Injury;medical countermeasure;Metabolic;Microscopic;Modeling;Molecular;Morbidity - disease rate;mortality;National Institute of Allergy and Infectious Disease;Neurologic;Nitriles;Pharmaceutical Preparations;Phosphines;Physiological;Poisoning;Population;Rattus;Research;research and development;Route;screening;Security;Therapeutic;Time;Toxic effect;Toxicology;United States National Institutes of Health

PROJECT_TITLE: Chemical Countermeasures Collaboration: Chemical Threats Affecting Cellular Respiration


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects

PROJECT_TERMS: Acrolein;Acute;Address;Affect;animal model development;Biochemical;chemical countermeasure;chemical threat;Chemicals;Chronic;Collaborations;design;Development;efficacy study;efficacy testing;Electrons;Environment;Evaluation;Exposure to;Eye;Eye Injuries;Funding;Genome;Genomics;Hospitals;Human;in silico;In Vitro;in vivo;Injury;medical countermeasure;Membrane;Microscopic;model development;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous Membrane;Mustard Gas;National Institute of Allergy and Infectious Disease;Pharmaceutical Preparations;Physiological;Poisoning;Population;Research;research and development;Route;screening;Security;Skin;Therapeutic;Time;Toxic effect;toxicant;Toxicology;United States National Institutes of Health

PROJECT_TITLE: Chemical Countermeasures Collaboration: Chemical Threats Affecting the Skin, Eyes, and Mucous Membranes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Eye Disease and Disorders of Vision;Physical Injury - Accidents and Adverse Effects

PROJECT_TERMS: Acute;Address;Animal Model;Chemicals;Chronic;Development;Evaluation;Eye;Eye Injuries;Funding;Human;in vivo Model;medical countermeasure;Mustard Gas;National Institute of Allergy and Infectious Disease;Poisoning;Research;screening;Security;Toxic effect;United States National Institutes of Health

PROJECT_TITLE: Supplemental funding for ROTR CHEM 1005 Development of Human Relevant Small Animal Models of Sulfur Mustard Toxicities


ADMINISTERING_IC: MD

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: ARLINGTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

ORG_STATE: TX

PI_NAMEs: SANCHEZ, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TITLE: Train and EMPOWER A Community Health workforce to achieve equity and reduce disparities in mental health (TEACH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(54)-R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE This proposal will define how interferon-gamma, a major T-cell cytokine abundant in atherosclerotic plaques, alters fuel utilization by the vascular cells that line the innermost layer of the coronary arteries, thereby making these vessels susceptible to atherosclerosis progression. This study, if successful, will improve our understanding of the adverse changes involving vascular metabolism in atherosclerosis and may lead to new therapeutic strategies to prevent heart attacks, strokes, and limb loss.

PI_NAMEs: LEE, LAUREL Y (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TITLE: Endothelial Metabolic Reprogramming by Interferon-gamma in Coronary Artery Disease

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ACTIVITY: ZIA

ADMINISTERING_IC: CL

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: BRAYLAN, RAUL  (contact)

PROJECT_TERMS: Abnormal megakaryocyte;Acute Megakaryocytic Leukemias;Acute Myelocytic Leukemia;Affect;Antigens;aspirate;Biopsy;Blood Platelets;Bone Marrow;Bone Marrow Aspiration;Buffers;Cell Lineage;Cell Maturation;Cells;Classification;Clinical;Collecting Cell;Complex;Consumption;cost;cytopenia;Data;density;Diagnostic;diagnostic value;Disease;disease diagnosis;DNA analysis;Dysmyelopoietic Syndromes;Electron Microscopy;Elements;Evaluation;Excision;Exhibits;Face;Filtration;Flow Cytometry;Fluorescence-Activated Cell Sorting;Frequencies;Germany;Glutaral;Goals;Hematological Disease;Hematology;Hematopoietic;Heterogeneity;Human;Idiopathic Thrombocytopenic Purpura;immunodeficiency;ITGB3 gene;Label;Laboratories;Large Megakaryocyte;Lobe;Lymphoid Cell;magnetic beads;Manuals;Marrow;Megakaryocytes;Methods;Microscopic;Monitor;Morphology;Myeloproliferative disease;Nuclear;Nylons;Patients;Ploidies;Polyploid Cells;Population;Preparation;Procedures;Process;Production;Proliferating;Proliferation Marker;rapid detection;Sample Size;Sampling;Stains;Suspensions;Techniques;Time;Visual;Wright-Giemsa Staining Method

PROJECT_TITLE: Rapid and Simple Isolation and Concentration Procedure for Human Megakaryocytes


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases

PI_NAMEs: AMBUDKAR, INDU S. (contact)

PROJECT_TERMS: Adopted;Affect;Affinity;Agonist;Amino Acid Sequence;Amino Acids;Autophagocytosis;Back;Binding;Binding Proteins;biophysical properties;Biophysics;Calcium;Cell membrane;Cells;Characteristics;Charge;chelation;comparative;Consensus Sequence;Data;Deglutition Disorders;Dental caries;design;Dose;EF Hand Motifs;EF-Hand Domain;Environment;Fluids and Secretions;Functional disorder;Generations;Geometry;Gland;Goals;Hour;Hydrolysis;insight;Ions;irradiation;Liquid substance;Maintenance;Malignant Neoplasms;Mediating;Mitochondria;Molecular;Molecular Conformation;molecular dynamics;monomer;Morphology;mouse model;Mus;mutant;Mutation;N-terminal;Neurotransmitters;novel;Oral health;oral infection;Osmosis;Phenotype;Phosphatidylinositol 4,5-Diphosphate;Physiological;Play;Positioning Attribute;prevent;Property;Protein Sequence Analysis;Proteins;recruit;Regulation;release of sequestered calcium ion into cytoplasm;Reporting;Research;response;Rest;Role;Saliva;Salivary Glands;SAM Domain;senescence;sensor;Series;Signal Transduction;STIM1 gene;Stimulus;Structure;Suggestion;thermostability;Time;Tubular Aggregate Myopathies;Tubular formation;Xerostomia

PROJECT_TITLE: Molecular Mechanisms Regulating Calcium Flux In Salivary Glands


ACTIVITY: ZID

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Patient Safety

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: LEE, JANICE  (contact)

PROJECT_TERMS: Back;Biometry;Caring;Clinic;Clinical;clinical center;Clinical Protocols;Clinical Research;Clinical Research Protocols;Consultations;Credentialing;Data;Databases;Dental;Dental Staff;dental surgery;Development;Emergency Situation;Epidemiology;Goals;Hospitals;human subject;improved;Infection Control;Institutional Review Boards;Maintenance;Measures;Metabolic Bone Diseases;Monitor;National Institute of Dental and Craniofacial Research;Nursing Research;operation;Oral Surgical Procedures;patient safety;Patients;Performance;pre-pandemic;Process;Protocols documentation;Quality Control;Reporting;Research;research and development;Research Support;Safety;Saran;Schedule;Services;simulation;Study Subject;United States National Institutes of Health;virtual;Visit;Writing

PROJECT_TITLE: NIDCR DIR Clinical Support Services


ACTIVITY: ZIE

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease

PROJECT_TERMS: Annual Reports;Award;career;career development;Clinical;clinical center;Clinical Research;Clinical Sciences;clinical training;craniofacial;Data;Dental;Dentists;Development;Disease;Education;Educational Activities;Ensure;Faculty;Fellowship;Fellowship Program;Goals;Grant;Health;Hybrids;improved;Individual;interest;Intramural Research;K-Series Research Career Programs;lectures;meetings;Mentors;Morbidity - disease rate;mortality;National Institute of Dental and Craniofacial Research;Nursing Faculty;Oral;Positioning Attribute;Program Development;programs;Publications;Reporting;Research;Research Activity;Research Personnel;research study;Research Training;Scientist;symposium;System;Talents;teacher;Training;training opportunity;Training Support;Translational Research;United States National Institutes of Health;virtual

PROJECT_TITLE: NIDCR DIR Clinical Training


ACTIVITY: ZIG

NIH_SPENDING_CATS: Biotechnology;Dental, Oral, and Craniofacial Disease

PI_NAMEs: DAVIDSON, LAUREN  (contact)

PROJECT_TERMS: Accreditation;Amendment;Animal Care and Use Committees;Animal Experimentation;animal facility;animal resource;Animals;Annual Reports;Breeding;Caring;Committee Members;Consultations;Dedications;Education;Gene Targeting;Health;Housing;Human Resources;International;Intramural Research Program;Modification;Mus;National Institute of Dental and Craniofacial Research;operation;Policies;Principal Investigator;programs;Protocols documentation;quality assurance;Regulation;Research;Research Personnel;research study;Resources;Review Committee;Rodent;Safety;Scientist;Services;Training;Transgenic Animals;Transgenic Mice;United States Department of Agriculture;United States National Institutes of Health;Writing

PROJECT_TITLE: NIDCR Annual Reports - Veterinary Resources Core


ACTIVITY: ZIJ

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

PI_NAMEs: HAUSER, BELINDA  (contact)

PROJECT_TERMS: Address;adeno-associated viral vector;Applications Grants;Award;Biomedical Research;Biotechnology;career;career development;Chalk;Clinical;clinical center;Clinical Research;Collaborations;college;Communication;craniofacial;Data;Dental;Dental Clinics;Dental Students;Development;Development Plans;Doctor of Philosophy;Educational Curriculum;Educational workshop;Electronics;Employee;Event;experience;Faculty;Fellowship;Funding;gene therapy;Goals;Government;graduate student;Grant;High School Student;Hispanic;improved;Individual;Industry;interest;Interview;Joints;K-Series Research Career Programs;Lead;Leadership;Medical;Mentors;Mexican Americans;minority student;National Human Genome Research Institute;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;National Institute of Dental and Craniofacial Research;Native Americans;Neurology;Ohio;Ophthalmology;Oral;Oral health;outreach;outreach program;Participant;Performance at work;Persons;Play;Policies;Population;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Preparation;professor;programs;Public Speaking;recruit;Research;Research Personnel;Resources;Role;Schedule;Science;Scientist;Series;skills;Slide;Societies;Structure;Student recruitment;Students;Study Section;summer internship;summer program;summer research;Surveys;symposium;System;tenure track;Training;Training and Education;training opportunity;Training Programs;United States National Institutes of Health;Universities;Update;virtual;Vocational Guidance;Work;Writing

PROJECT_TITLE: NIDCR Office of Training and Education


ADMINISTERING_IC: ES

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: COLUMBUS

ORG_NAME: BATTELLE MEMORIAL INSTITU

ORG_STATE: OH

PI_NAMEs: SPARROW, BARNEY  (contact)

PROJECT_TITLE: Evaluation of multiple test agents for functional cardiovascular changes in rats


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Dissemination and Implementation Research;Neurosciences;Prevention

ORG_CITY: FAIRFAX

ORG_STATE: VA

PI_NAMEs: KHOSLA, MRINAL  (contact)

PROJECT_TERMS: Achievement;Chronic;Communication;Communities;cost;Country;Disease;Educational workshop;Funding;Funding Agency;Health;implementation research;Income;Indigenous;Joints;knowledge base;Leadership;Location;Logistics;low and middle-income countries;meetings;National Institute of Child Health and Human Development;prevent;Prevention;programs;Reporting;Research;Research Personnel;Research Training;Resources;Series;Services;skills;Training Programs;United States National Institutes of Health;web site;working group

PROJECT_TITLE: NICHD SERVICES: FIC LOGISTICS SUPPORT


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Estrogen;Women's Health Research

ORG_CITY: MORRISVILLE

ORG_NAME: HEALTH DECISIONS, INC.

ORG_STATE: NC

PI_NAMEs: DART, CLINT  (contact)

PROJECT_TERMS: Clinical;Clinical Trials;Clinical Trials Network;Collaborations;Contraceptive Agents;Contracts;cost;Development;efficacy trial;Estradiol;Evaluation;Formulation;Good Manufacturing Process;Government;Health;Investigational New Drug Application;Laboratories;manufacture;manufacturing organization;men;Mission;National Clinical Trials Network;National Institute of Child Health and Human Development;Nestorone;New York;Phase;phase III trial;Population;Production;prototype;Qualifying;Reporting;Sampling;Site;Specific qualifier value;Supervision;Technology Transfer;Therapeutic Equivalency;timeline;Vaginal Ring;Vendor;Woman;Work

PROJECT_TITLE: ACQUISITION OF THE NESTORONE ESTRADIOL (NES/E2) VAGINAL RING AS CONTRACEPTIVE


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Immunization;Infectious Diseases;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROJECT_TERMS: Acceleration;adenoma;Adult;Adverse effects;African American;Age;aged;American;Animals;Antibiotics;Antigens;APC gene;ApcMin/+ mice;Bacillus;Bacteria;Bacteroides fragilis;base;Binding;Biological;biomaterial compatibility;Cancer Etiology;cancer risk;Cell Physiology;Cell-Mediated Cytolysis;Chemopreventive Agent;Child;cigarette smoking;Clinical;Codon Nucleotides;Colitis;Colon;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Colorectal Neoplasms;Colorectal Polyp;Containment;COVID-19;COVID-19 vaccine;Cytoprotection;Data;Dental Plaque;design;Development;Diagnosis;Disease;Distant;Distant Metastasis;DNA;draining lymph node;Dysplasia;Early Diagnosis;effector T cell;efficacy testing;Encapsulated;Enhancers;Epitopes;Familial Adenomatous Polyposis Syndrome;Family history of;Feces;Fortification;Fusobacteria;Fusobacterium;Fusobacterium nucleatum;gene repair;Genetic;Germ-Line Mutation;glycerophosphodiester phosphodiesterase;Goals;Gram-Negative Bacteria;Helicobacter pylori;Hepatitis B Virus;Hereditary Nonpolyposis Colorectal Neoplasms;Human;Human Papilloma Virus Vaccine;Immune;Immune Sera;Immunity;immunogenic;immunogenicity;Immunoglobulins;Immunosuppression;improved;in vivo;Incidence;Individual;Infection;Infection prevention;infection rate;Infectious Agent;Inflammatory Bowel Diseases;Inherited;Innate Immune Response;Intervention;ITIM;Lesion;lipid nanoparticle;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;malignant stomach neoplasm;Measures;Mediating;Membrane;Messenger RNA;Methodology;microbiota;Microsatellite Instability;Mismatch Repair;Mismatch Repair Deficiency;Modeling;Modification;Morbidity - disease rate;mortality;mouse model;mutation carrier;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Non-Insulin-Dependent Diabetes Mellitus;Nonsense Mutation;Obesity;Oncogenic;Operative Surgical Procedures;Oral;Organ;pathogen;Patients;Phase;Population;Preclinical Drug Development;preclinical efficacy;premalignant;Prevalence;prevent;Prevention strategy;Preventive;Preventive measure;Preventive vaccine;Primary carcinoma of the liver cells;Program Development;prophylactic;Proteins;Proteomics;Pseudouridine;Race;receptor;Recommendation;Recording of previous events;Regimen;Regulatory T-Lymphocyte;Reporter;Resistance;Risk;Risk Factors;RNA;RNA vaccine;Role;scale up;screening;Small Intestinal Neoplasm;Survival Rate;Syndrome;System;T-Lymphocyte;Time;Tissues;tumor;Tumor Escape;tumor growth;tumor microenvironment;Tumor Promotion;tumorigenesis;tumorigenic;United States;United States Preventative Services Task Force;Update;Vaccination;Vaccine Antigen;vaccine platform;Vaccines;vaccinology;Vesicle;Virulence Factors;Wild Type Mouse

PROJECT_TITLE: BASE TITLE: PREVENT PRECLINICAL DRUG DEVELOPMENT PROGRAM:  PRECLINICAL EFFICACY AND INTERMEDIATE ENDPOINT BIOMAKERSTASK ORDER TITLE: VACCINES AGAINST FUSOBACTERIUM FOR FAP-AND LYNCH SYNDROME-ASSOCIA


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PI_NAMEs: KRISHNAMURTHY, ASHOK KUMAR (contact)

PROGRAM_OFFICER_NAME: MILLER, CHRISTOPHER MANDEL

PROJECT_TERMS: Address;Big Data Methods;Blood;Communication;Communities;community empowerment;community engaged approach;community engagement;Community of Practice;computing resources;Coupled;Data;Data Commons;data resource;Data Science;Data Set;Data Storage and Retrieval;design;Disease;diverse data;Elements;empowerment;Ensure;Environment;Exhibits;expectation;experience;Fostering;Geography;Goals;Health;Heart;Heart Diseases;Hematological Disease;Infrastructure;insight;interest;Knowledge;knowledge integration;Knowledge Management;Leadership;Learning;light weight;Lung;Lung Diseases;Methods;Mission;multiple datasets;National Heart, Lung, and Blood Institute;National Research Council;Nature;novel;organizational structure;Outcome;Performance;Persons;Process;programs;Reporting;Research;Research Institute;Research Personnel;Risk;Science;Series;Services;Sleep;Sleep Disorders;Sociology;software development;Source;Strategic vision;synergism;Talents;United States National Academy of Sciences;United States National Institutes of Health;Vision;Work

PROJECT_TITLE: NHLBI Data Stage Coordinating Center

SUFFIX: SA


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities

PI_NAMEs: YEH, JEN JEN  (contact)

PROGRAM_OFFICER_NAME: NOTHWEHR, STEVEN F

PROJECT_TITLE: Project 3: Transcriptomic subtypes, response predictions, and therapy selection


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PROJECT_TERMS: Acceleration;design;Development;Diagnostic tests;Health Technology;HIV;innovation;point of care;programs;RADx;RADx Tech;technology validation;Testing;United States National Institutes of Health;Viral Load result

PROJECT_TITLE: RADx Innovation Funnel for Health Technologies - Validation Center


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Cancer;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Patient Safety;Radiation Oncology;Rare Diseases

PROJECT_TERMS: Address;Adoption;advanced analytics;Affect;Aging;Algorithms;Anatomy;Area;base;Behavior;Cancer Control;cancer radiation therapy;Capital;chemoradiation;Clinical;Clinical Data;clinical implementation;Clinical Treatment;Communities;Community Hospitals;Complication;Computer software;connected health;cost;Coupled;Data;Data Set;Decision Making;Decision Support Systems;design;Development;Devices;Diagnosis;Dose;Economics;Emerging Technologies;Environment;Equipment;Evaluation;evidence base;Evolution;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Health;Health Policy;Health Technology;Healthcare;Human;Human Resources;Image;image guided radiation therapy;improved;in silico;Incentives;Individual;individual patient;individualized medicine;innovation;insight;Instruction;Insurance Carriers;Life;Linear Accelerator Radiotherapy Systems;low and middle-income countries;Magnetic Resonance Imaging;malignant mouth neoplasm;Malignant neoplasm of larynx;Malignant neoplasm of pharynx;Malignant Neoplasms;Medical Device;Medicare;Methodology;Methods;Modeling;models and simulation;Modernization;Monitor;Morbidity - disease rate;multidisciplinary;Neck Cancer;new technology;next generation;Normal tissue morphology;novel;Operations Research;Organ;Outcome;Overdose;Patient Care;Patient imaging;Patients;Physicians;Policies;Probability;Process;programs;Property;prototype;Provider;Radiation;Radiation therapy;radiation-induced injury;Regimen;Research;Resources;response;Risk;risk stratification;Schedule;Science;Self-Help Devices;Series;side effect;SMART health;soft tissue;Software Tools;standard care;Structure;support tools;Survivors;System;Systems Integration;Techniques;Technology;technology intervention;theories;Time;tool;Toxic effect;treatment planning;treatment response;treatment stratification;tumor;Tumor Volume;Uncertain Risk;Uncertainty;Validation;Variant;Work

PROJECT_TITLE: SCH: Personalized Rescheduling of Adaptive Radiation Therapy for Head & Neck Cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Orthopoxviruses;Rare Diseases

PROJECT_TERMS: Development;inhibitor;Orthopoxvirus;Pharmaceutical Preparations;Poxviridae;small molecule;small molecule inhibitor;therapeutic development

PROJECT_TITLE: Identification and Development of Small Molecule Orthopoxvirus Inhibitors


FUNDING_MECHANISM: SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_CITY: NEW YORK

ORG_NAME: MEDNET, INC.

ORG_STATE: NY

PI_NAMEs: HOUSRI, NADINE  (contact)

PROJECT_TERMS: Awareness;cancer prevention;cancer therapy;clinical trial enrollment;Clinical Trials;Collaborations;cost;demographics;Development;Disease;Eligibility Determination;Enrollment;Goals;improved;Information Resources;Location;National Cancer Institute;Oncologist;online community;participant enrollment;Patients;Phase;Physicians;point of care;Population Heterogeneity;predictive tools;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;recruit;Site;Small Business Innovation Research Grant;social;Southwest Oncology Group;Technology;Testing;tool;trial enrollment;United States

PROJECT_TITLE: 2024 SBIR TOPIC 465: CANCER PREVENTION AND TREATMENT CLINICAL TRIALS TOOLS FOR RECRUITMENT AND RETENTION OF DIVERSE POPULATIONS


ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Antimicrobial Resistance;Clinical Trials;efficacy evaluation;Gonorrhea;gonorrhea vaccine;Immunization;Neisseria meningitidis;Pharmaceutical Preparations;Phase;prevent;randomized placebo controlled study;Resistance;vaccine development;Vaccines

PROJECT_TITLE: Meningococcal Immunization Against Gonococcal Infection Clinical Trial


ORG_CITY: CHAPPAQUA

ORG_NAME: VIZLITICS INC.

PI_NAMEs: SHEARER, CHAD  (contact)

PROJECT_TERMS: Address;Authorization documentation;Awareness;Breast;Cancer Patient;Characteristics;Chest;Clinic;Clinical;clinical trial enrollment;clinical trial recruitment;Clinical Trials;Communication;Communities;Comprehensive Cancer Center;Computer software;Contracts;dashboard;Data;data modeling;Disease;Documentation;drug development;Eligibility Determination;Enrollment;Evaluation;Failure;Feedback;gastrointestinal;Genitourinary system;Goals;Head and neck structure;Human;improved;Individual;innovation;insight;Link;Lung;Malignant Neoplasms;Measurement;Medical;member;Notification;Nurses;Participant;patient health information;Patients;Performance;Population Heterogeneity;Provider;recruit;Recruitment Activity;Reporting;Rest;screening;Screening procedure;Secure;Site;Software Tools;statistics;Structure;System;systematic review;Testing;Time;tool;Universities;verification and validation;Work

PROJECT_TITLE: ONTRIAL: AI-DRIVEN AND EMR INTEGRATED CLINICAL TRIAL RECRUITMENT TOOL USED BY CLINICAL TRIAL AND PROVIDER TEAMS FOR RECRUITMENT OF DIVERSE POPULATIONS.


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Mutations in the Crumbs homologue-1 (CRB1) gene lead to severe blinding disorders including retinitis pigmentosa and Leber congenital amaurosis. To date, there is no treatment for CRB1-mediated retinal diseases, and classical gene augmentation techniques are complicated by the expression of multiple CRB1 isoforms in cell-type-distinct localizations within the retina. This project will develop a CRB1 isoform-independent prime editing approach by establishing retinal organoid disease models and preclinical vectors in order to establish proof-of-concept for CRB1 prime editing therapeutics.

PI_NAMEs: QUINN, PETER MARTIN JOHN (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TITLE: Prime editing for Crumbs homologue 1 (CRB1) Inherited Retinal Dystrophies

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Antimicrobial Resistance;Bacterial Infections;Bacteriophages;Gram-Negative Bacteria;Infection;pathogen;pre-clinical assessment;preclinical study;Resistance;safety assessment;Staphylococcus aureus;therapeutic development

PROJECT_TITLE: Preclinical Assessment of Phage Therapy for Pathogen Decolonization


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Precision Medicine;Primary Health Care;Racial and Ethnic Minority Health Research

ORG_CITY: MC LEAN

ORG_NAME: MITRE CORPORATION

PI_NAMEs: KUNZMAN, JON  (contact)

PROJECT_TERMS: Address;African American;Age;All of Us Research Program;Biomedical Research;clinical investigation;clinical trial participant;cohort;Communities;Development;disability;Enrollment;Ensure;Ethnic Origin;Federally Qualified Health Center;Gender;Geography;Glean;Health Personnel;Hispanic;Hispanic Populations;improved;member;Monitor;operation;Phase;Population;Precision Medicine Initiative;programs;Race;sex;socioeconomics;Support Contracts;United States Dept. of Health and Human Services;United States National Institutes of Health;volunteer;Work


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lymphatic Research;Pneumonia and Influenza;Prevention;Vaccine Related

PROJECT_TERMS: 2019-nCoV;COVID-19 vaccine;Development;efficacy testing;Immune response;Immunological Models;Influenza;lymph nodes;lymphoid organ;medical countermeasure;microphysiology system;nonhuman primate;Tissues;vaccine development;Vaccines;Viral Vaccines

PROJECT_TITLE: Non-Human Primate Lymphoid Organ Chips for Vaccine Assessment


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

PROJECT_TERMS: Clinical Research;Cyclic GMP;enterotoxigenic Escherichia coli;Human;vaccine development;Vial device

PROJECT_TITLE: Provision of cGMP Vials of Challenge Strain of Enterotoxigenic E. coli for use in Clinical Studies


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: Columbus

ORG_DEPT: DENTISTRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The proposed research is relevant to public health because the understanding of the role of heparan sulfate- Sclerostin interaction in bone formation is ultimately expected to provide novel therapeutic targets in treating many diseases associated with exaggerated bone loss. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to seeking fundamental knowledge that will help to reduce illness and enhance health.

PI_NAMEs: LI, MIAOMIAO  (contact)

PROGRAM_OFFICER_NAME: WAN, JASON

PROJECT_TITLE: Demystify Heparan Sulfate–Sclerostin Interactions in Bone Formation

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE  The proposed research will identify molecular changes in the extracellular matrix in the heart that occur with aging. The project will also evaluate the role of sex hormones and inflammation in these processes.

PI_NAMEs: CIESLIK, KATARZYNA A. (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TITLE: Proteomics based mapping of cardiac extracellular matrix to define sex and age-dependent changes.

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: ZHOU, TONGQING  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Affinity;Animal Model;Antigens;Area;ART protein;artificial intelligence model;Binding;Biological Assay;Characteristics;clinical application;computer framework;Cryoelectron Microscopy;Data;Dedications;design;design and construction;Development;Diffusion;effectiveness evaluation;Engineering;Epitope Mapping;Epitopes;Formulation;future pandemic;generative artificial intelligence;Genetic;Genetic Variation;graph neural network;HIV envelope protein;HIV-1;Immune response;Immunization;immunogenicity;in silico;Individual;innovation;large language model;Libraries;Maps;Methodology;Modeling;mosaic;nanoparticle;neutralizing antibody;next generation;novel;pandemic preparedness;Pathway interactions;pre-clinical;preclinical trial;Process;Proteins;Research;scaffold;self assembly;System;Techniques;Technology;tool;vaccination strategy;vaccine development;Vaccines;Validation;Variant;Viral Proteins

PROJECT_TITLE: Generative AI-guided design of HIV-1 cocktail immunogen


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Osteogenesis Imperfecta;Pediatric;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Non-Human

PROJECT_TERMS: 3-Dimensional;age related;Aging;Animal Model;Animals;Basic Science;Biological Assay;Bone Marrow Examination;Bone Marrow Stem Cell;Bone Regeneration;Clinical Research;Clinical Treatment;Clinical Trials;cohort;cone-beam computed tomography;craniofacial;Craniofacial Abnormalities;craniofacial complex;Databases;Deformity;Dental;dentofacial;Development;Diagnosis;Disease;Disease Management;DNA Sequence Alteration;Dysmorphology;Early Intervention;Environment;Face;Genomics;Genotype;Goals;Growth and Development function;human disease;Image;imaging modality;improved;Knock-in Mouse;Loeys-Dietz Syndrome;Mandible;Mathematics;Methodology;Methods;Modeling;mouse model;Mus;Musculoskeletal;Natural History;Natural regeneration;Operative Surgical Procedures;Oral;Oral health;Osteogenesis Imperfecta;osteoprogenitor cell;Patients;Phenotype;Pre-Clinical Model;programs;Protocols documentation;Quality of life;rib bone structure;Risk;RNA Sequences;Role;skeletal abnormality;skull base;Statistical Data Interpretation;stem cell function;Technology;Testing;Three-Dimensional Imaging;Tooth Abnormalities;Tooth structure;Transforming Growth Factor beta Receptors;Translational Research;Variant

PROJECT_TITLE: Craniofacial Anomalies and Regeneration


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

ORG_STATE: MD

PI_NAMEs: PAL, RANAJIT  (contact)

PROJECT_TERMS: Advanced Development;African;AIDS Vaccines;Award;Clinical;Complement;Contracts;Development;Evaluation;Evaluation Studies;Funding;Grant;HIV vaccine;HIV-1;Immune response;Immunotherapy;Investigator-Initiated Research;Local Microbicides;Modality;National Institute of Allergy and Infectious Disease;Newcastle disease virus;nonhuman primate;pre-clinical;preclinical evaluation;preclinical study;Prevention;Prevention strategy;programs;Proteins;Research Personnel;Resources;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Research;Vaccines

PROJECT_TITLE: Conduct Study P193: Evaluation of Immune Responses after Priming with Newcastle Disease Virus and Boosting with Trimeric gp145 Proteins from Indian and African Clade C HIV-1 Isolates


PROJECT_TERMS: Advanced Development;Agonist;AIDS Vaccines;aluminum sulfate;Award;Clinical;Complement;Contracts;Development;env Glycoproteins;Evaluation;Evaluation Studies;Funding;Grant;HIV vaccine;HIV-1;immunogenicity;Immunotherapy;Intramuscular;Investigator-Initiated Research;Local Microbicides;Modality;National Institute of Allergy and Infectious Disease;nonhuman primate;pre-clinical;preclinical evaluation;preclinical study;Prevention;Prevention strategy;programs;Research Personnel;Resources;Route;vaccine candidate;Vaccine Design;vaccine development;vaccine evaluation;Vaccine Research;Vaccines

PROJECT_TITLE: Evaluation of the Immunogenicity and Efficacy of HIV-1 Clade A BG505 SOSIP.664 Env Glycoprotein Trimer Vaccine Administered with TLR Agonist or Alum Adjuvants


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: BASELER, BETH  (contact)

PROJECT_TERMS: Adult;Blinded;Categories;Clinical;Coagulation Process;Consent;Coronavirus;COVID-19;COVID-19 patient;Data;Disease Progression;double-blind placebo controlled trial;Enrollment;Ensure;Functional disorder;Funding;Future;Hospitalization;Immunoglobulins;individual patient;Inpatients;International;Intravenous Immunoglobulins;Life;Medical;mortality;National Institute of Allergy and Infectious Disease;Organ;Organ failure;Outcome;Participant;participant enrollment;Patients;Pharmaceutical Preparations;Placebos;prevent;primary endpoint;Protocols documentation;Randomized;randomized trial;remdesivir;Research Personnel;Respiration Disorders;Safety;Sample Size;Site;standard of care;study population;Symptoms

PROJECT_TITLE: ON BEHALF OF NIAID-DCR, FACILITATE THE CONDUCT OF TWO, RANDOMIZED TRIALS AS DETAILED BELOW IN I AND II:I.	A RANDOMIZED BLINDED CONTROLLED TRIAL OF TH


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: Advanced Development;AIDS Vaccines;Award;Clinical;Complement;Contracts;Development;Evaluation Studies;Funding;Grant;HIV envelope protein;HIV vaccine;HIV-1 vaccine;Immunotherapy;Investigator-Initiated Research;Local Microbicides;Macaca mulatta;Modality;Mucous Membrane;National Institute of Allergy and Infectious Disease;nonhuman primate;pre-clinical;preclinical evaluation;preclinical study;Prevention;Prevention strategy;programs;Research Personnel;Resources;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Research;Vaccines;Virus

PROJECT_TITLE: Comparison of Bivalent vs Pentavalent Subtype C Envelope HIV-1 Vaccine Efficacy Following Mucosal Virus Challenge


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

ORG_STATE: CA

PI_NAMEs: WANG, CHRISTINA  (contact)

PROJECT_TERMS: Androgens;avoid pregnancy;birth control;Clinical Trials;Contraceptive Agents;contraceptive efficacy;Contraceptive methods;Couples;Dose;efficacy clinical trial;Gel;Goals;Gonadotropins;Male Contraceptive Agents;men;Methods;Nestorone;Production;Progestins;Regimen;Research;research clinical testing;Safety;Site;sperm cell;Spermatogenesis;Testing;Testosterone

PROJECT_TITLE: CCTN - CLINICAL EVALUATION OF NESTORONE GEL AND TESTOSTERONE - SITES FOR MALE CONTRACEPTIVE RESEARCH


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Genetic Testing;Genetics;Neurodegenerative;Neurosciences;Pediatric;Prevention

ORG_CITY: MENANDS

ORG_NAME: NYSDOH/HEALTH RESEARCH, INC.

PI_NAMEs: CAGGANA, MICHELLE  (contact)

PROJECT_TERMS: Adolescent;Adult;Advisory Committees;Affect;Age;Age of Onset;Alleles;American;Arylsulfatases;Austria;Authorization documentation;autosome;Behavioral;Biochemical;Biological Assay;Birth;Blood;Brain;brain magnetic resonance imaging;Cessation of life;Characteristics;Child;Child Health;Clinic;Clinical;clinical subtypes;Cognitive;Confusion;Consensus;Contractor;Contracts;Demyelinations;Detection;Development;Developmental Disabilities;Diagnosis;Diagnostic tests;Disabling condition;Disease;Disease Progression;Dryness;Early Diagnosis;early onset;Early treatment;Environment;enzyme activity;enzyme deficiency;Evaluation;Exclusion;follow-up;gene therapy;Genes;genetic testing;Genotype;Germany;Goals;Guidelines;Health Personnel;Hereditary Disease;improved;Individual;infancy;Infant;Intellectual functioning disability;Laboratories;Left;Leukocytes;Liquid Chromatography;loss of function;Measurement;Measures;Medical Genetics;medical schools;medical specialties;Metachromatic Leukodystrophy;Monitor;Motor;MTCH1 gene;Mutation;Neonatal Screening;Nervous System Trauma;Newborn Infant;Onset of illness;Pathogenicity;Peripheral Nervous System Diseases;physically handicapped;Pilot Projects;Population;Prevalence;Privatization;prospective;Randomized;Rare Diseases;Reagent;Recommendation;Reporting;Sampling;screening;screening guidelines;screening panel;screening program;Sensitivity and Specificity;Severities;Spottings;Sulfoglycosphingolipids;Symptoms;tandem mass spectrometry;Testing;Treatment outcome;Urine;Validation;Variant;white matter

PROJECT_TITLE: NEWBORN SCREENING PILOT STUDY FOR METACHROMATIC LEUKODYSTROPHY (MLD)


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: YORK

ORG_NAME: ASSOCIATION OF FOOD AND DRUG OFFICIALS

PHR: RFA-FD-22-021 AFDO’s System for Agriculture, Food, Health, E-Inspections and Registration (SAFHER): Project Narrative The Association of Food and Drug Officials’ (AFDO) efforts under this cooperative agreement are intended to support the planning, development, implementation, operation, and maintenance of data management system to be utilized by State, Local, Tribal, and Territorial (SLTT) partners in both human and animal food programs. AFDO will build on an already established user community of stakeholders to enhance FDA’s ORA Data Exchange capabilities by utilizing software development methodologies (i.e. Agile) to ensure a long-term sustainable data management system that is easy to use and maintain by state regulatory partners during and after this cooperative agreement. Through effective governance, vendor procurement, and resource management, this project will deliver a national regulatory data repository that will work towards achieving a national Integrated Food Safety System (IFSS) while promoting One Health and supporting domestic mutual reliance initiatives to protect the food supply and advance public health.

PI_NAMEs: MANDERNACH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: LAC, ANH

PROJECT_TITLE: System for Agriculture, Food, Health, E-inspection, and Registration (SAFHER)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Neurosciences

ORG_CITY: SAN JOSE

ORG_NAME: CCS ASSOCIATES, INC.

PI_NAMEs: SIGMAN, CAROLINE C (contact)

PROJECT_TERMS: Area;Discipline;drug development;drug discovery;experience;gene therapy;Industry;Leadership;Medical;programs;Services;United States National Institutes of Health;Writing

PROJECT_TITLE: MEDICAL WRITING CONSULTING SERVICES


ORG_CITY: CLIFTON

PROJECT_TERMS: Area;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biometry;Cell Therapy;Chemistry;Contracts;Development;drug development;drug discovery;Drug Kinetics;gene therapy;manufacture;Medical;National Institute of Neurological Disorders and Stroke;novel therapeutics;Pharmacodynamics;product development;Program Development;quality assurance;Quality Control;Recommendation;Regulatory Affairs;Services;therapeutic development;Toxicology;United States National Institutes of Health;Writing

PROJECT_TITLE: Biological Therapeutics Product Development Subject Matter Expert Consulting Services


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Neurosciences;Pain Research

PROJECT_TERMS: Area;Biological Assay;Biological Products;Biological Response Modifier Therapy;Biometry;Cell Therapy;Chemistry;clinical pain;Contracts;Development;drug development;drug discovery;Drug Kinetics;gene therapy;Helping to End Addiction Long-term;manufacture;Medical;National Institute of Neurological Disorders and Stroke;novel therapeutics;Pain;Pain management;Pharmacodynamics;product development;Program Development;quality assurance;Quality Control;Recommendation;Regulatory Affairs;Services;Speed;therapeutic development;Toxicology;United States National Institutes of Health;Writing


ORG_CITY: ALEXANDRIA

PROJECT_TERMS: Award;Biological Products;Biological Response Modifier Therapy;Contracts;Development;drug development;drug discovery;National Institute of Neurological Disorders and Stroke;Recommendation;Services;therapeutic development

PROJECT_TITLE: Biologics - gap analysis services


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ARDMORE

PROJECT_TERMS: Area;Biological Products;Biological Response Modifier Therapy;Contractor;drug development;drug discovery;experience;Feedback;Leadership;member;Program Development;programs;Research;Services;United States National Institutes of Health

PROJECT_TITLE: This service is to provide Leadership an experienced executive level professional in research and it requires an external advisory experts directed to provide independent advice. POP: May 1, 2024 to A


ORG_CITY: BRONX

PROJECT_TERMS: Area;Biological Products;Biological Response Modifier Therapy;Contractor;drug development;drug discovery;experience;Feedback;Leadership;member;Program Development;programs;Services;United States National Institutes of Health

PROJECT_TITLE: This service is for the External Oversight Committee (EOC) of the Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) is an external advisory group of experts directed to provide indepen


ORG_CITY: ARCADIA

PROJECT_TERMS: Area;Biological Products;Biological Response Modifier Therapy;Contractor;drug development;drug discovery;experience;Feedback;Leadership;member;Program Development;programs;Services;Travel;United States National Institutes of Health

PROJECT_TITLE: This service is for consulting and travel reimbursement.  POP: 06/05/2024 to 06/04/2025


ORG_CITY: ORANGEBURG

ORG_NAME: NATHAN S. KLINE INSTITUTE FOR PSYCH RES

PHR: Narrative  The ability to process sensory stimuli in the context of previous stimuli is a fundamental function in mammalian brains. Context processing is altered in the visual system in a number of diseases, including autism spectrum disorders and schizophrenia, undermining how affected individuals perceive and relate to a changing environment. In order to understand the biological mechanisms of basic contextual modulation in primary visual cortex, this project applies a suite of cutting-edge optical tools to study neural circuits in mice, providing potentially new insights into understanding and treating visual processing pathology.

PI_NAMEs: HAMM, JORDAN P (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Circuits for deviance detection in V1

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ORG_CITY: ANN ARBOR

ORG_STATE: MI

PROJECT_TERMS: Area;Biological Products;Biological Response Modifier Therapy;Consultations;Contractor;drug development;drug discovery;experience;Feedback;Leadership;member;Program Development;programs;Recommendation;Services;Travel;United States National Institutes of Health

PROJECT_TITLE: This service is for Consultation review and recommendations of BPN-Biologics Projects and travel. POP: 06/06/2024 to 06/05/2025.


ORG_CITY: SYKESVILLE

ORG_NAME: NEUIMMUNE BIOLOGICS, INC.

PROJECT_TERMS: Area;Biological Products;Biological Response Modifier Therapy;Consultations;Contractor;drug development;drug discovery;experience;Feedback;Leadership;member;Program Development;programs;Services;United States National Institutes of Health

PROJECT_TITLE: Biological Therapeutics consultation services


ORG_CITY: BROOKEVILLE

PROJECT_TERMS: Biological Products;Biological Response Modifier Therapy;Cell Therapy;Chemistry;Contracts;Development;drug development;drug discovery;gene therapy;manufacture;National Institute of Neurological Disorders and Stroke;novel therapeutics;product development;Program Development;Recommendation;Services;therapeutic development;United States National Institutes of Health

PROJECT_TITLE: BIOLOGICAL THERAPEUTICS PRODUCT DEVELOPMENT SUBJECT MATTER EXPERT CONSULTING SERVICES TO SUPPORT THE DEVELOPMENT OF CELL AND GENE THERAPY PRODUCTS


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Pain Research;Regenerative Medicine

PHR: This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management.

PROJECT_TERMS: Biological Products;Biological Response Modifier Therapy;Cell Therapy;Chemistry;clinical pain;Contracts;Development;drug development;drug discovery;gene therapy;Helping to End Addiction Long-term;manufacture;National Institute of Neurological Disorders and Stroke;novel therapeutics;Pain;Pain management;product development;Program Development;Recommendation;Services;Speed;therapeutic development;United States National Institutes of Health


ORG_CITY: CINCINNATI

PROJECT_TERMS: Biochemistry;Biological Products;Biological Response Modifier Therapy;Chemistry;Development;experience;gene therapy;Individual;manufacture;National Institute of Neurological Disorders and Stroke;oligonucleotide therapeutics;Process;programs;Services;therapeutic development;United States National Institutes of Health

PROJECT_TITLE: THERAPEUTIC OLIGONUCLEOTIDE PLATFORM BIOLOGICS CHEMISTRY, MANUFACTURING AND CONTROLS (CMC), SUBJECT MATTER EXPERT CONSULTING SERVICES.


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL CANCER INSTITUTE

PROJECT_TERMS: Address;Adoption;Advisory Committees;Agreement;American;American Cancer Society;American Society of Clinical Oncology;Area;cancer prevention;care coordination;Caring;Clinical;clinical care;Clinical Laboratory Information Systems;Collaborations;Common Data Element;Communities;Community Health;Complex;Data;Data Collection;Data Element;data exchange;data quality;Data Set;data standards;Decision Making;Diagnosis;Ecosystem;Education;Educational Activities;Electronic Health Record;Evaluation;Exercise;Fast Healthcare Interoperability Resources;Future;Government;Health;health equity;health inequalities;health information technology;health organization;Health Personnel;Health Services Accessibility;Healthcare;Human Resources;Improve Access;improved;Information Systems;innovation;interest;interoperability;Joints;Laboratories;Malignant Neoplasms;Maps;Measurement;meetings;Methods;National Cancer Institute;Oncology;Patient-Focused Outcomes;Patients;Persons;Policies;Population Surveillance;programs;Provider;Public Health;Radiation Oncology;Recommendation;Registries;Reproducibility;Research;Research Personnel;Resources;Societies;System;Tribes;United States;United States National Institutes of Health;Work

PROJECT_TITLE: NIH-ONC Cancer Domain Collab FTE


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Neurosciences;Opioids;Pain Research

PI_NAMEs: SHURTLEFF, DAVID  (contact)

PROJECT_TERMS: Advertisements;Analgesics;Anatomy;Attention;Brain;Brain region;Cerebrum;chronic pain;chronic pain patient;chronic widespread pain;clinical trial recruitment;Data;data acquisition;Data Analyses;dopamine system;Double-Blind Method;Emotions;endogenous opioids;Environment;Fibromyalgia;gray matter;healthy volunteer;Individual;Institutional Review Boards;intravenous administration;Magnetic Resonance Imaging;Methods;Naloxone;neural;Neurotransmitters;Newspapers;Opioid;Opioid Antagonist;Pain;Pain management;pain patient;pain processing;pain relief;Paper;patient population;Patients;Persons;placebo analgesia;Placebo Effect;Placebos;Population;Preparation;Protocols documentation;Psychological Factors;Psychophysics;Publishing;Randomized;recruit;Role;Saline;social media;System;Testing;Training;United States National Institutes of Health

PROJECT_TITLE: Brain Mechanisms of Pain Processing and Modulation


NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Mental Health;Neurosciences;Pain Research

ORG_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

PROJECT_TERMS: Absence of pain sensation;Address;Affective;Analgesics;Animals;Blood Pressure;Cervical spine;Clinical;comparison control;Crossover Design;Data;depressive symptoms;Double-Blind Method;Ear;Electric Stimulation;Esthesia;experimental study;External Ear;Galvanic Skin Response;Goals;Heart Rate;heart rate variability;Human;improved;Left;Literature;Measures;Mediating;men;Moods;negative mood;Pain;Pain intensity;pain perception;pain reduction;Pain Threshold;positive mood;Randomized;recruit;Respiration;response;Role;screening;Site;Spinal nerve structure;Stimulus;treatment-resistant depression;vagus nerve stimulation;Vagus nerve structure;Visit;Woman

PROJECT_TITLE: Effects of external ear stimulation on pain perception and mood


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Complementary and Integrative Health;Neurosciences;Pain Research;Rare Diseases

PROJECT_TERMS: Brain imaging;Congenital Pain Insensitivity;Data;Data Collection;DNA Sequence Alteration;Enrollment;Esthesia;Individual;Merkel Cells;Methods;Nerve Fibers;Neurologic;Neurons;Pain;pain perception;Participant;Pathway interactions;Patients;Peripheral;Piezo 2 ion channel;Proprioception;Proteins;receptor;Role;Sensory;somatosensory;Structural defect;Testing;Touch sensation;Variant

PROJECT_TITLE: Patients with Altered Somatosensory or Pain Perception


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Complementary and Integrative Health;Neurosciences;Pain Research

PROJECT_TERMS: Address;Adolescence;Age;behavior measurement;Brain;chronic pain;chronic pain patient;Clinical;Clinical Research;Data Analyses;Data Collection;design;Emotional;Ethnic Origin;Evaluation;Functional Imaging;Functional Magnetic Resonance Imaging;Gender;healthy volunteer;Human;Interview;Laboratories;Magnetic Resonance Imaging;Measurement;Medical History;Medical Records;Nationalities;neuromechanism;Outcome Measure;Pain;Pain Disorder;Pain management;Participant;Patient Outcomes Assessments;Persons;Phenotype;Physiological;Preparation;Psychophysics;Publications;Publishing;Role;Sensory;structural imaging;study population;Testing;tool;Touch sensation

PROJECT_TITLE: General Studies of Chronic Pain


ACTIVITY: ZIC

NIH_SPENDING_CATS: Biomedical Imaging;Chronic Pain;Complementary and Integrative Health;Neurosciences;Pain Research

PROJECT_TERMS: Affect;Attention;Basic Science;Behavioral;Brain;Brain imaging;Clinical Research;Complementary Health;Doctor of Philosophy;Emotions;Environment;Exposure to;Functional Magnetic Resonance Imaging;Genetic;Health;Healthcare;healthy volunteer;improved;innovation;Integrative Medicine;Intervention;Intramural Research Program;Investigation;Leadership;Mission;model organism;Molecular;National Center for Complementary and Integrative Health;Neurosciences;new technology;novel strategies;Pain;Pain management;pain perception;pain processing;Patients;Productivity;programs;Research;Research Personnel;Research Project Grants;Resources;Role;Safety;Scientist;Series;System;Transcranial magnetic stimulation;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Office of the Scientific Director


NIH_SPENDING_CATS: Complementary and Integrative Health;Pain Research;Patient Safety

PROJECT_TERMS: Affective;Ambulatory Care Facilities;Appointments and Schedules;Clinical;clinical center;clinical investigation;clinical practice;Clinical Protocols;Clinical Research;Contracts;cost;Credentialing;Data Analyses;Databases;Development;Ear;Fellowship;Infrastructure;Institutional Review Boards;Laboratories;Medical;Moods;National Center for Complementary and Integrative Health;next generation;Nurse Practitioners;Nursing Research;Operations Research;Pain;Patient Admission;Patients;Phenotype;Physicians;Preparation;pressure;programs;Protocols documentation;Regulation;repository;Research Personnel;Research Support;Resolution;Resources;Science;Services;Touch sensation;Training;Translational Research;Travel;United States National Institutes of Health

PROJECT_TITLE: Clinical Support Services


NIH_SPENDING_CATS: Bioengineering;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: WESTAT, INC.

PI_NAMEs: MONTALVAN, REBECCA  (contact)

PROJECT_TERMS: Address;Area;Artificial Intelligence;authority;Award;Behavioral;Biological Process;Biomedical Research;catalyst;Chronic lung disease;Clinical;Clinical Data;Collaborations;Data;Data Set;database of Genotypes and Phenotypes;Dedications;Disease;Disparity;Ecosystem;Environmental Exposure;Exhibits;experience;Familiarity;Gender;genome sequencing;Health;Heart Diseases;Hematological Disease;idiopathic pulmonary fibrosis;Image;improved;Infrastructure;innovation;interest;Internet;Intervention;Lung Diseases;Machine Learning;machine learning method;Measures;Medical;Medical Imaging;Methods;Molecular;National Heart, Lung, and Blood Institute;Nature;novel;operation;organizational structure;Outcome;petabyte;Phenotype;Positioning Attribute;Precision Medicine Initiative;Prevention;Procedures;Process;programs;Progress Reports;Radiogenomics;radiomics;Research;Research Institute;Research Personnel;Research Project Grants;Research Proposals;Research Subjects;Risk Factors;Role;Running;sex;Sex Differences;Sleep Disorders;Structure;success;synergism;System;Therapeutic;Time;Trans-Omics for Precision Medicine;Update;whole genome;Woman;Women's Health;Work

PROJECT_TITLE: Trans-Omics for Precision Medicine (TOPMed) Artificial Intelligence Coordinating Center (AI-CC)


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

PI_NAMEs: COLLINS, MICHAEL  (contact)

PROJECT_TERMS: Abnormal Cell;Achondroplasia;American;American Heart Association;Area;autosome;Benign;Biological;Biological Markers;Biological Process;Biology;Blood Vessels;bone;bone mass;Bone Resorption;burden of illness;calcification;Calcium;Calcium ion;calcium phosphate;Calcium-Sensing Receptors;Cell Lineage;Cell surface;Cellularity;Child;Clinical;Clinical Research;Clinical Treatment;Collaborations;Dedications;Dental;Deposition;Development;Disease;Dose;Durapatite;Dysplasia;Enrollment;extracellular;Familial tumoral calcinosis;Family;fibroblast growth factor 23;Fibroblast Growth Factor Receptors;fibroblast-activating factor;Fibrous Dysplasia;functional disability;G-Protein-Coupled Receptors;gain of function;Goals;Homeostasis;human disease;Hydroxyapatites;hydroxyl group;Hypocalcemia;Hypoparathyroidism;imaging modality;improved;Individual;Inflammation;inorganic phosphate;International;Investigation;Ions;Life;Ligands;Maintenance;Maps;McCune-Albright Syndrome;meetings;member;Mesenchymal Cell Neoplasm;mineralization;Minerals;Mission;mutant;National Institute of Dental and Craniofacial Research;Osteoclasts;osteogenic;Osteomalacia;Paper;Paraneoplastic Syndromes;Pathogenesis;Patients;PET/CT scan;Pharmaceutical Preparations;phase 2 study;phase 3 study;phase III trial;Physiology;Play;Principal Investigator;Process;Productivity;programs;PTH gene;public-private partnership;Rare Diseases;Research;Research Support;response;Role;Scanning;Secondary to;skeletal disorder;skeletal stem cell;small molecule;Societies;Techniques;therapy development;Tissues;TNFSF11 gene;Tooth structure;Training;transcriptomics;translational physician;translational scientist;translational study;tumor;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Update;Variant;Vascular calcification;Work

PROJECT_TITLE: Skeletal Disorders and Mineral Homeostasis Section


NIH_SPENDING_CATS: Cancer

PI_NAMEs: JACKSON, SHANNON  (contact)

PROJECT_TITLE: NCI OD-Frederick; 125073 Bldg. 560, Roof Exhaust Stacks; 9/24/2018 - 3/18/2022


ORG_CITY: DURHAM

ORG_DEPT: PEDIATRICS

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative The genomics era was anticipated to bring with it the capacity to use molecular biology tools to identify specific cancer-causing mutations and translate that information into better therapy. This problem has not been realized for most children with cancer, especially diseases like fusion-positive rhabdomyosarcoma (FP-RMS) that harbors few highly recurrent mutations. Our project will develop two new tools – a Bayesian-based, integrative analyses of genomic and epigenetic features of FP-RMS, and FP-RMS PDX models and cell lines where the oncogenic fusion protein can be rapidly and reversibly switched “on” and “off” – which will reveal cancer drivers and tumor suppressors, and how they can be influenced by the fusion protein and, potentially, targeted.

PI_NAMEs: SKAPEK, STEPHEN X (contact);XU, LIN

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TITLE: Nominating vulnerabilities in fusion oncoprotein-driven rhabdomyosarcoma


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative While it is universally accepted that undernutrition negatively impacts the reproductive success of an individual, relatively little is known about the central mechanisms whereby inadequate food intake suppresses GnRH/LH secretion. This project seeks to investigate the role of a neuronal-mediated (agouti- related peptide signaling) and a central immune-mediated (interleukin-1β signaling) mechanism in the regulation of LH secretion during undernutrition and realimentation. The results of this proposal will help to identify central targets useful for future therapeutic strategies to prevent or lower the risk of disorders such as cardiovascular disease and depression that are associated with delayed puberty.

PI_NAMEs: NESTOR, CASEY C (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TITLE: Nutritional Regulation of Luteinizing Hormone Secretion

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS clinical trial group;Biological Products;Cell Aging;Clinical Trials;Dasatinib;Funding;HIV;HIV-1;HIV/AIDS;improved;Names;National Institute of Allergy and Infectious Disease;Pharmacologic Substance;pilot trial;Price;programs;Services;Vendor

PROJECT_TITLE: NIAID-DLA Pharmaceutical Vendor Program: HIV/AIDS Study Support


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb) is the number one infectious disease killer in the world. Altering mitochondrial homeostasis has been repeatedly associated with susceptibility to Mtb and exacerbation of Mtb pathogenesis. By understanding how crosstalk between Mtb virulence factors and mitochondria influences immune outcomes, we might one day be able to therapeutically target mitochondria as part of tuberculosis patient treatment plans.

PI_NAMEs: PATRICK, KRISTIN LEIGH;WATSON, ROBERT OWEN (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TITLE: Mitochondria as crucial regulators of innate immune outcomes during Mycobacterium tuberculosis infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Kidney Disease;Orphan Drug;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human;Transplantation

ORG_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PI_NAMEs: CHILDS, RICHARD  (contact)

PROJECT_TERMS: Accounting;Acute Graft Versus Host Disease;Adoptive Immunotherapy;Adult;Affinity;Allogenic;Allografting;Alloimmunization;Antibodies;Antigen Targeting;Antigens;antitumor effect;Aplastic Anemia;Area;Autologous;Back;Bone Marrow;bone marrow failure syndrome;Bortezomib;cancer immunotherapy;Cancer Patient;Cancer Vaccines;CCR5 gene;CD34 gene;Cell Proliferation;Cell Separation;Cells;Cellular Immunity;Cellular immunotherapy;chimeric antigen receptor T cells;Chimerism;chronic graft versus host disease;Clear Cell;Clear cell carcinoma;Clear cell renal cell carcinoma;Clinical;Clinical Research;Clinical Trials;Clone Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Colony-Stimulating Factor Receptors;conditioning;CSF3 gene;Cyclophosphamide;cytokine;Cytotoxic T-Lymphocytes;Data;demethylation;Depsipeptides;Development;Disadvantaged;Disease-Free Survival;DNA;Donor person;donor stem cell;Dose;Effector Cell;Endogenous Retroviruses;Engraftment;Equus caballus;expression cloning;FCGR3B gene;first-in-human;flasks;fludarabine;follow-up;Future;gene induction;Genes;genetic manipulation;genetically modified cells;Goals;Graft Rejection;Hematologic Neoplasms;Homing;Human;Hypoxia;Hypoxia Inducible Factor;Immunity;Immunodeficient Mouse;Immunologics;immunotherapy trials;improved;In Vitro;in vivo;Infusion procedures;insight;Institutional Review Boards;Kidney Neoplasms;Laboratory Research;leukemia;Ligands;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Metastatic Renal Cell Cancer;Methods;Minor;Monoclonal Antibodies;Multiple Myeloma;Multivariate Analysis;Natural Killer Cells;Neoplasm Metastasis;neoplastic cell;Neutropenia;neutrophil;Non-Neoplastic Hematologic and Lymphocytic Disorder;Normal tissue morphology;novel;overexpression;paroxysmal nocturnal hemoglobinuria;participant enrollment;Patients;Pattern;Peptides;peripheral blood;phase 1 study;Phase I Clinical Trials;Phenotype;Population;post-transplant;prevent;primary endpoint;Production;programs;Proteins;Proviruses;Recovery;Refractory;Regimen;Renal Carcinoma;Renal Cell Carcinoma;Reporting;Research Personnel;Retroviridae;Risk Reduction;Secondary to;selective expression;Serology;Solid Neoplasm;Source;Specificity;Speed;Stem cell transplant;stem cells;Survival Rate;System;T-Cell Depletion;T-Cell Receptor Therapy;T-Lymphocyte;Testing;TNFSF10 gene;transcription factor;Transfusion;Translational Research;Transplant Recipients;Transplantation;tumor;Tumor Antigens;Tumor Immunity;Umbilical Cord Blood;Umbilical Cord Blood Transplantation;Universities;VHL Gene Inactivation;Viral;Whole-Body Irradiation;Work

PROJECT_TITLE: Allogeneic and Autologous Immunotherapy for cancer and nonmalignant hematological disorders


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology

PROJECT_TERMS: Anemia;Clinical Trials;cytopenia;Dose;Immune;Immune response;Mediating;Monitor;participant enrollment;Patients;Pharmaceutical Preparations;Phosphotransferases;post-transplant;primary outcome;Resolution;response;SYK gene;Thrombocytopenia;Toxic effect;week trial

PROJECT_TITLE: Fostamatinib to Treat Post-Transplant Immune-mediated Cytopenias


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL LIBRARY OF MEDICINE

PI_NAMEs: SCHEUERMANN, RICHARD  (contact)

PROJECT_TERMS: analysis pipeline;artificial intelligence method;cell type;Cells;Characteristics;Communities;comparative;computer based Semantic Analysis;Data;data format;data repository;Development;Diagnostic;diagnostic biomarker;differential expression;Disease;Elements;epigenomics;experimental study;Exposure to;Extramural Activities;Funding;Gene Expression;Genes;Genetic Markers;Goals;graph database;high throughput analysis;Individual;interoperability;Intramural Research;Knowledge;knowledgebase;Link;Literature;Metadata;Natural Language Processing pipeline;novel diagnostics;Output;Pathway interactions;Pattern;Peer Review;Pharmaceutical Preparations;Phenotype;phenotypic data;Preparation;Process;Production;Publications;Publishing;PubMed;Reporting;repository;Research;Resources;response;Sampling;Semantics;single cell genomics;Source;Specimen;Standardization;Stream;Structure;Technology;Text;therapeutic target;Therapeutic Uses;Tissues;transcriptomics;United States National Institutes of Health;United States National Library of Medicine;whole genome

PROJECT_TITLE: Analysis and semantic representation of cell phenotype characteristics


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

PI_NAMEs: DIAMOND, JEFFREY S (contact)

PROJECT_TERMS: Action Potentials;analog;Anatomy;base;Behavior;Calcium Channel;Cells;Characteristics;Communication;Dependence;Docking;Electron Microscopy;electron tomography;Electroretinography;Ensure;experimental study;Freezing;Functional disorder;Goals;Heterogeneity;In Vitro;Light;Manuscripts;Mediating;Membrane Potentials;Morphology;mouse model;nanometer resolution;neural network;Neurons;Output;Pathologic;Physiological;Population;pressure;presynaptic;Presynaptic Terminals;Probability;Process;Retina;Retinal Ganglion Cells;Retinitis Pigmentosa;ribbon synapse;Rod;Role;Signal Pathway;signal processing;Signal Transduction;Site;Specificity;Structure;Synapses;Synaptic Membranes;Synaptic Transmission;Synaptic Vesicles;Testing;Tissues;Vesicle;vesicular release;Vision;Visual;visual processing;voltage;Work

PROJECT_TITLE: Synaptic Mechanisms in the Mammalian Retina


PROJECT_TERMS: Algorithms;Amacrine Cells;Biological Models;Blood capillaries;Blood Vessels;Book Chapters;Calcium Signaling;cell type;Cells;Complex;Cone;Darkness;Data;Dopamine;experimental study;Feedback;ganglion cell;Gap Junctions;Genetic;Goals;graduate student;Image;Individual;Inherited;interest;Journals;Learning;Light;Machine Learning;Manuscripts;Mediating;Methods;Morphology;Muller's cell;Mus;Neurons;Output;Pathway interactions;Pericytes;Photophobia;Physiological;Preparation;presynaptic;Process;Publishing;response;Retina;Rod;signal processing;Signal Transduction;Stimulus;Synapses;synaptic inhibition;tool;Visual;visual processing;Work

PROJECT_TITLE: Circuit function and visual signal processing in the retina


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: LOGAN

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PI_NAMEs: COOK, MIKAYLA  (contact)

PROJECT_TERMS: Avian Influenza;Birds;Contracts;Development;Evaluation;Human;infectious disease model;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H5N1 Subtype;Influenza B Virus;influenza virus strain;mouse model;pandemic potential;seasonal influenza;therapeutic development;therapeutic evaluation

PROJECT_TITLE: Task A04: Mouse Models for Evaluation of Therapeutics against Human Seasonal Influenza and Avian Influenza Strains with Pandemic Potential


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infectious Diseases

ORG_CITY: HINCKLEY

ORG_NAME: ICON GOVERNMENT AND PUBLIC HEALTH SOLUTIONS, INC.

PI_NAMEs: WRIGHT, TED  (contact)

PROJECT_TERMS: clinical application;Clinical Research;Clinical Trials;Communicable Diseases;Contracts;Good Clinical Practice;National Institute of Allergy and Infectious Disease;Operations Research;programs;quality assurance;Regulation;Research;response;Support Contracts;Vendor

PROJECT_TITLE: Vendor Audit Support Through the Comprehensive and Rapid Response to NIAID Research Programs (CARRRP) Contract


NIH_SPENDING_CATS: Antimicrobial Resistance;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: SAINT CHARLES

ORG_NAME: EUROFINS PANLABS, INC.

ORG_STATE: MO

PI_NAMEs: BODE, JACOB  (contact)

PROJECT_TERMS: Antimicrobial Resistance;Biological;Biological Assay;Chemistry;Combating Antibiotic Resistant Bacteria;Communicable Diseases;Development;Development Plans;Drug Kinetics;Evaluation;Gram-Negative Bacteria;Gram-Positive Bacteria;In Vitro;in vivo;Interventional Agent Development;Lead;lead optimization;manufacture;pathogen;pre-clinical;product development;programs;Property;Rodent;Safety;screening;Services;Therapeutic;therapeutic development;Toxicology;Toxin

PROJECT_TITLE: Task E14: Lead Optimization Screening Assays for ADMET, Safety Profiling, Rodent Pharmacokinetics and MTD


ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: PROJECT NARRATIVE Despite optimization of intensive multi-agent chemotherapy regimens, infants with B-cell acute lymphoblastic leukemia (ALL), most often characterized by chromosomal rearrangements involving KMT2A (KMT2A-R), have aggressive disease and dismal outcomes. Chimeric antigen receptor T cells targeting CD19 (CD19CART) have demonstrated unprecedented efficacy in children with relapsed or refractory pediatric ALL; however, many CD19CART-treated patients will experience ALL relapse after initial response. This study aims to improve immunotherapeutic treatment of KMT2A-R ALL by investigating rational combinatorial therapeutic approaches with CD19CART and small molecule inhibitors that target key biologic vulnerabilities of this high-risk pediatric leukemia subtype.

PI_NAMEs: NISWANDER, LISA MADALEN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TITLE: Leveraging small molecule inhibitors to improve CD19 CAR T cell immunotherapy for KMT2A-rearranged ALL

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Clinical Research;Health Services;Precision Medicine

ORG_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

PROJECT_TERMS: Advisory Committees;Advocate;Agreement;All of Us Research Program;Biomedical Research;cohort;Data;Data Aggregation;data quality;design;Disease;Evaluation;experience;Goals;handheld mobile device;Health;health administration;Health Personnel;Healthcare;Individual;Knowledge;Mediator;Modeling;Observational Study;Participant;patient engagement;precision medicine;preference;programs;Provider;Quality Control;Research;Source;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans Health Administration;volunteer;wearable device;working group

PROJECT_TITLE: IAA between the Department of Veterans Affairs (VA) Veterans Health Administration (VHA) and National Institutes of Health (NIH)


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PI_NAMEs: MASCARELLA, WAYNE  (contact)

PROJECT_TERMS: Agonist;antagonist;Area;Basic Science;Behavioral;Biochemical;Brain imaging;Central Nervous System;chemical synthesis;Clinical Research;Clinical Trials;drug distribution;drug of abuse;Functional Magnetic Resonance Imaging;Good Manufacturing Process;Human;Legal patent;Ligands;Longitudinal Studies;Mental Health;Molecular;National Institute of Mental Health;novel;Pharmaceutical Preparations;Pharmacology;Positron-Emission Tomography;Primates;programs;Psychotropic Drugs;Radiolabeled;receptor;Signal Transduction;single photon emission computed tomography;Source

PROJECT_TITLE: NIMH SYNTHESIS AND DISTRIBUTION OF DRUGS OF ABUSE AND RELATED COMPOUNDS. JUNE 16, 2024 - JUNE 15, 2025. TASK ORDER 75N95024F00002 (TO7). N01DA-22-8944.


NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: DMITROVSKY, ETHAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Area;Budgets;Computers;Contract Services;Contractor;Contracts;data management;Development;Diagnosis;Funding;Head;Health;HIV Infections;HIV/AIDS;Human Herpesvirus 8;improved;In Vitro;in vivo;International;Laboratory Animal Science;Libraries;Maintenance;Malignant Neoplasms;Modeling;Molecular Virology;multidisciplinary;nonhuman primate;Office of Administrative Management;operation;Prevention;Principal Investigator;programs;repaired;repository;Research;research and development;Safety;Satellite Viruses;Services;statistical service;Technology;tumor;Viral Epidemiology;Virus;Work

PROJECT_TITLE: AIDS AND CANCER VIRUS PROGRAMS (ACVP)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: HUNTER COLLEGE

PI_NAMEs: KRAMPIS, KONSTANTINOS  (contact)

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;African;Algorithms;American;Applications Grants;Artificial Intelligence;artificial intelligence algorithm;Asian;Bioinformatics;biological systems;Biometry;Biostatistics Core;Cancer Biology;cancer genetics;cancer health disparity;cancer prevention;career;Cell division;ChIP-seq;Clinical;clinical application;Clinical Informatics;Clinical Trials;Collaborations;Collection;Communities;computer infrastructure;Consultations;cost effective;Data;Data Analyses;Data Protection;data resource;Data Set;Database Management Systems;Development;Diverse Workforce;DNA sequencing;Doctor of Philosophy;Education;Environment;Epigenetic Process;epigenomics;Equity;ethnic minority population;experience;Experimental Designs;Fostering;Funding;Future;Genetic;Genomics;Goals;Grant;graph neural network;Health Disparities Research;High Performance Computing;Informatics;Infrastructure;innovation;Institution;instrument;interest;Investigation;Knowledge Extraction;Laboratories;Latinx;Leadership;Link;Machine Learning;Malignant Neoplasms;Manuscripts;Medical Genetics;member;Methods;minority investigator;minority trainee;Mission;Molecular;Multiomic Data;New Jersey;New York City;novel;Phase;Philadelphia;Pilot Projects;Play;Population Sciences;preclinical study;Productivity;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Qualitative Research;racial minority population;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Resource Sharing;Retrieval;Ribosomal RNA;Role;Science;Secure;Services;single-cell RNA sequencing;skills;software development;statistics;Students;Surface;System;systemic barrier;Technology;tool;Training;transcriptome sequencing;Underrepresented Minority;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Core (BBC)


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Fairfax

ORG_NAME: INOVA HEALTH CARE SERVICES

PHR: Project Narrative This project will contribute to the field by creating small volume sample collection, processing, and storage practices that are rigorous, reproducible, and validated for use in multi-omic studies. We will use machine learning methods to develop new models of neonatal sepsis from stool, blood, skin, and saliva for detection, differential diagnoses, and/or prediction of systemic inflammatory to infection. Our multi-omic network will establish molecular targets (pathways, genes, and metabolites) for future experimental studies to validate proposed causal mechanisms in sepsis progression and recovery.

PI_NAMEs: PRESCOTT, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TITLE: The Scientific Value of Premature Infant Biospecimens Collection

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PI_NAMEs: FORTUNE, SARAH  (contact)

PROJECT_TERMS: Animal Model;Animals;cohort;Computer Models;Goals;HIV;Human;Immune;Immune Evasion;Immune response;Immune Targeting;Immunity;Immunologics;improved;multidisciplinary;Mus;Mycobacterium Infections;Mycobacterium tuberculosis;non-tuberculosis mycobacteria;nonhuman primate;programs;Research Activity;Research Personnel;response;Sampling;SIV;Technology;Testing;Tissues;Translating;Tuberculosis;Tuberculosis Vaccines;vaccine strategy

PROJECT_TITLE: Immune Mechanisms of Protection Against Mycobacterium Tuberculosis Center (IMPAC-TB)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Burden of Illness;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PI_NAMEs: ALTIN, JOHN  (contact)

PROJECT_TERMS: Africa South of the Sahara;African;Alleles;alpha-beta T-Cell Receptor;Antigens;Bar Codes;Binding;Biological Assay;burden of illness;CD4 Positive T Lymphocytes;Clonal Expansion;cohort;Complex;Contractor;Data;Dimensions;Disease;DNA;Epitopes;Generations;HLA Antigens;innovation;Length;Link;Location;Maps;Measures;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;novel;pathogen genome;Pathogenesis;Peptides;Peripheral Blood Mononuclear Cell;Phenotype;Population;Proteins;Proteome;Resources;Role;Sampling;single cell sequencing;Specific qualifier value;Specificity;T cell response;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Epitopes;Testing;Time;transcriptome;Tuberculosis;two-dimensional;Validation

PROJECT_TITLE: MYCOBACTERIUM TUBERCULOSIS PROTEOME-WIDE EPITOPE DISCOVERY AND HOST TRANSCRIPTOME-WIDE T CELL PHENOTYPING IN HIGH DISEASE BURDEN POPULATIONS


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ALBANY

ORG_NAME: ALBANY MOLECULAR RESEARCH, INC.

PI_NAMEs: MEITZ, SUSAN  (contact)

PROJECT_TERMS: Acceleration;analytical method;Clinical Trials;Contractor;Contracts;Data;Development;Documentation;Dosage Forms;drug candidate;drug development;drug distribution;early phase clinical trial;efficacy study;Formulation;good laboratory practice;Good Manufacturing Process;Grant;Human;Investigational Drugs;Investigational New Drug Application;Label;manufacture;method development;novel therapeutics;Pharmaceutical Preparations;Pharmacologic Substance;preclinical efficacy;Preparation;Process;Production;programs;Regulation;small molecule;support network;Testing;Toxicology;United States Food and Drug Administration;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: BPN PROJECT BPN-36938


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: RALEIGH

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Project Narrative The vital single-cell lining (epithelium) of digestive organs is sustained by cells that lie beneath it (mesenchyme) and provide known and unknown signals. This proposal aims to provide new insights into the mesenchymal compartment’s role during fetal development and restoration of intestinal stem cells after lethal cell injury. The studies will improve understanding of how interactions between the epithelium and mesenchyme may be harnessed in the future to develop new treatment approaches toward inflammatory bowel disorders and cancers.

PI_NAMEs: MCCARTHY, NEIL  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Address;Adult;Agonist;Anatomy;antagonist;base;Biological Assay;Biology;Birth;Bone Morphogenetic Proteins;Cancer Etiology;CD81 gene;cell injury;Cell Line;Cell Separation;cell type;Cells;Cessation of life;Coculture Techniques;Colorectal Cancer;Constitution;crypt cell;Data;Development;Disease;Elements;Embryo;Environment;epithelial repair;Epithelium;Equilibrium;Exhibits;experimental study;fetal;Fetal Development;Fingers;Future;Gene Expression Profile;Genetic;Growth;Growth Factor;Homeostasis;improved;In Vitro;in vivo;Inflammatory Bowel Diseases;Injury;insight;intestinal crypt;intestinal epithelium;intestinal homeostasis;Intestines;Knock-out;Ligands;Malignant Neoplasms;Mesenchymal;Mesenchyme;Methods;Microscopy;Molecular;Molecular Profiling;Mus;Natural regeneration;novel;novel therapeutic intervention;Organ;Organoids;Pathway interactions;PDGFRA gene;Population;Process;progenitor;Proliferating;protein function;Protein Inhibition;Reaction;Recombinants;regenerative;Regenerative response;Regulation;Resolution;response;Rest;restoration;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Small Intestines;Stem Cell Development;stem cell homeostasis;stem cell niche;stem cell proliferation;stem cell self renewal;stem cells;Structure;Testing;Tissues;transcriptome sequencing;Tube;United States;Villous;Villus

PROJECT_TITLE: Mesenchymal regulation of fetal intestinal development and adult regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Millions of Americans suffer from chronic pain, opioid misuse, and opioid use disorder. New intervention strategies that integrate mindfulness, physical therapy, and/or medications for opioid use disorder (MOUD) are needed to improve health outcomes in these vulnerable patients. To accomplish this aim, we propose the Opioid and Pain Effectiveness research Network for Mindfulness and Integrative Health Intervention Development (OPEN-MIIND), a multidisciplinary research center dedicated to addressing the opioid crisis.

PI_NAMEs: GARLAND, ERIC LEE (contact);ZEIDAN, FADEL

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TITLE: Analgesic and Opioid Sparing Brain Mechanisms of Mindfulness-Oriented Recovery Enhancement for Chronic Low Back Pain

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: HIV/AIDS

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: TYCKO, ROBERT  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Capsid;Capsid Proteins;Dependence;Electron Microscopy;Equipment;Freezing;Funding;gag Gene Products;HIV-1;innovation;Intramural Research Program;Laboratories;light scattering;Measurement;Methods;microwave electromagnetic radiation;Molecular;Molecular Structure;monomer;National Institute of Diabetes and Digestive and Kidney Diseases;nephelometry;novel;Nuclear Magnetic Resonance;Peptide Hydrolases;Phytic Acid;Preparation;Process;programs;Research;Sampling;self assembly;solid state nuclear magnetic resonance;Source;Time;Virion;X-Ray Crystallography

PROJECT_TITLE: Time-resolved studies of HIV-1 capsid protein self-assembly


PI_NAMEs: BEWLEY, CAROLE  (contact)

PROJECT_TERMS: Affinity;Animal Model;Antibodies;antibody-dependent cell cytotoxicity;Bacterial Antibodies;Binding;biophysical analysis;Cells;Complement-Dependent Cytotoxicity;Complex;design and construction;Drug Kinetics;glycosylation;Goals;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV Infections;HIV/AIDS;IgG Receptors;Immune response;improved;In Vitro;in vivo;inhibitor;Kinetics;Lectin;Link;Mammalian Cell;Mannose;milligram;nanomolar;Neonatal;neonatal Fc receptor;novel;Oligosaccharides;Parents;Plasma;Plasmids;Polysaccharides;prevent;Process;Production;Proteins;receptor;Research;Serum;Signal Transduction;Surface;Surface Plasmon Resonance;Testing;Toxicity Tests;Work

PROJECT_TITLE: Antibody-protein conjugates as inhibitors of HIV/AIDS


NIH_SPENDING_CATS: Contraception/Reproduction;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: OAKLAND

ORG_NAME: PUBLIC HEALTH INSTITUTE

PI_NAMEs: YOUNG HOLT, BETHANY  (contact)

PROJECT_TERMS: Anti-Infective Agents;Architecture;Archives;Bacterial Vaginosis;Chlamydia;Congresses;Contraceptive Agents;Contraceptive methods;Contracts;Data;data dictionary;Data Sources;data standards;data submission;Databases;design;Development;Evaluation;experience;Funding Agency;Goals;HIV;HIV Infections;informant;information gathering;interest;Interview;Maintenance;men;National Institute of Child Health and Human Development;novel;Participant;pathogen;Peer Review;Phase;Population;Pregnancy;prevent;Prevention;Preventive;Property;Publishing;Research;Research Personnel;Resources;Series;sexual and reproductive health;Sexually Transmitted Diseases;Source;STI prevention;Structure;System;system architecture;Technology;technology development;Testing;Travel;Update;Woman;Work

PROJECT_TITLE: DEVELOPING A DATABASE FOR SEXUALLY TRANSMITTED INFECTIONS (STI) PREVENTATIVES TO FACILITATE INFORMATION EXCHANGE FOR MULTIPURPOSE PREVENTION TECHNOLOGIES of Contraception Research


NIH_SPENDING_CATS: Endocrine Disruptors;Health Effects of Indoor Air Pollution;Prevention

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: Characterizing occupational exposures provides a real-world context for NIEHS toxicology studies. To achieve this, NIOSH will characterize occupational exposures using a multidisciplinary approach to include toxicology, epidemiology, engineering, industrial science, and occupational medicine. These studies contribute to the prevention of diseases or adverse effects caused by environmental exposure to chemical or physical agents by identifying sources of exposure and strategies for mitigation.

PROJECT_TERMS: Adverse effects;Agreement;Air;air monitoring;analytical method;Animal Model;chemical property;Chemicals;Cholesterol;Communication;Complement;Construction Materials;consumer product;Contracts;design;Development;disorder prevention;Electronic Mail;Engineering;Enrollment;Environment;Environmental Exposure;Epidemiology;exposed human population;Exposure to;Food Handling;Goals;Government;Hazard Assessment;Hazard Identification;Health;Human;in vivo;Industrialization;Industry;insight;interdisciplinary approach;Manuals;Marketing;Medical Device;Methodology;Methods;National Institute of Environmental Health Sciences;Occupational;Occupational Exposure;Occupational Medicine;Outcome;Participant;perfluorooctane;perfluorooctanoic acid;pharmacokinetic model;physical property;Poly-fluoroalkyl substances;Population;Preparation;Production;recruit;Recruitment Activity;Research;Research Priority;Research Proposals;Resistance;Review Literature;sample collection;Sampling;Science;Site Visit;Source;Stains;Sulfate;symposium;Telephone;Textiles;Thyroid Function Tests;Toxicology;Workplace

PROJECT_TITLE: Occupational Exposure Assessment of Emerging Per- and Polyfluoroalkyl Substances (PFAS)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: COLORADO SPRINGS

ORG_NAME: UNIVERSITY OF COLORADO

PHR: NARRATIVE Current approaches do not have enough resolution to distinguish the heterogeneity of the identical NPs’ PC composition. In this study we aim to develop a highly sensitive MagLev system to probe the small variations in the PC composition of the same identical NPs in terms of number and/or type of the proteins.

PI_NAMEs: ASHKARRAN, ALIAKBAR  (contact)

PROGRAM_OFFICER_NAME: CHEN, JERMONT

PROJECT_TITLE: Heterogeneity of protein corona (PC) composition using highly sensitive magnetic levitation (MagLev) system


ORG_CITY: LINCOLN

ORG_NAME: UNIVERSITY OF NEBRASKA LINCOLN

ORG_STATE: NE

PI_NAMEs: SHAW, JARED BRYAN (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Amines;Amino Acids;analytical method;Antibodies;Antibody Diversity;Antibody Response;Area;B-Lymphocytes;Base Pairing;Biological;biopharmaceutical industry;C-terminal;Cells;Charge;Chemicals;Clone Cells;Communication;Communities;Complementarity Determining Regions;Complex;cost;Cysteine;Derivation procedure;Detection;Development;Digestion;Dimensions;Discipline;Dissociation;disulfide bond;Electrons;emerging pathogen;Ensure;experimental study;Gases;Health;Higher Order Chromatin Structure;Human;Hybridomas;Hybrids;Immune response;Immunoglobulin Fragments;Immunooncology;Immunotherapy;improved;informatics tool;innovation;instrument;instrumentation;ionization;Ions;Light;Malignant Neoplasms;mass spectrometer;Methods;Modeling;Monoclonal Antibodies;Nebraska;novel;Patients;Peptides;Performance;Phase;polyclonal antibody;Preparation;Proteins;Proteome;Proteomics;Quality Control;Resources;Sampling;Serum;tandem mass spectrometry;Techniques;Technology;Therapeutic antibodies;Therapeutic Monoclonal Antibodies;therapeutic protein;Time;ultraviolet;Vaccines

PROJECT_TITLE: De novo proteomics platform for therapeutic antibody discovery


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endocrine Disruptors;Prevention;Women's Health Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: BURNIN, DEBRA  (contact)

PROJECT_TERMS: ADME Study;androgenic;Androgens;Animal Model;Animals;Area;Biological Products;Biological Testing;Blood;candidate identification;chemical synthesis;Chemicals;Chronic;Clinical;clinical lot;Clinical Research;Clinical Trials;Clinical Trials Network;Contraceptive Agents;Contraceptive Devices;Contraceptive methods;Contractor;Contracts;Data;design;Development;Devices;drug candidate;drug development;Drug Evaluation;Drug Formulations;Drug Kinetics;Embryonic Development;Endocrine;Enrollment;estrogenic;Evaluation;Excretory function;Female Contraceptive Agents;Fertility;Formulation;Goals;good laboratory practice;Good Manufacturing Process;Hormones;In Vitro;in vitro Assay;in vivo;Injectable;Investigational New Drug Application;Levonorgestrel;lot production;Male Contraceptive Agents;manufacture;men;Metabolic;Methods;Microsomes;Mission;Modeling;National Institute of Child Health and Human Development;new chemical entity;novel;novel therapeutics;Oral;Ovulation;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Pharmacology;Phase;Plasma;Play;population health;pre-clinical;preclinical development;preclinical study;Process;Prodrugs;product development;Production;Progestins;Program Development;programs;Property;Proteins;Protocols documentation;recruit;Report (document);Research;research and development;research clinical testing;Research Personnel;Research Support;Role;Route;Safety;screening;Services;sperm cell;sperm function;stability testing;System;Testing;Tissues;Toxic effect;Toxicokinetics;Toxicology;Woman;Work

PROJECT_TITLE: BIOLOGICAL TESTING FACILITY (BTF) – GOOD LABORATORY PRACTICE (GLP) TOXICOLOGY AND FERTILITY AND EARLY EMBRYONIC DEVELOPMENT (FEED) STUDIES AND PRECLINICAL STUDIES OF CONTRACEPTIVES


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_NAME: DYNPORT VACCINE COMPANY, LLC

PI_NAMEs: LONG, CASEY  (contact)

PROJECT_TERMS: clinical trial implementation;Clinical Trials;Clinical Trials Unit;Communicable Diseases;COVID-19 therapeutics;Dose;Double-Blind Method;early phase clinical trial;Intervention;Investigation;National Institute of Allergy and Infectious Disease;New Agents;phase 1 study;Phase I Clinical Trials;Placebo Control;Prevention;Randomized;Study Subject

PROJECT_TITLE: Task C1: A Randomized, Double Blind, Placebo-Controlled, Multiple Ascending Dose Phase 1 Study of SARS-CoV-2 Therapeutics