NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

PHR: PROJECT NARRATIVE This project is to conduct a prospective study of Rwandan women living with HIV (WLWH) who were and were not immunized against human papillomavirus (HPV) types 6, 11, 16, and 18. The primary goal is to measure the long-term, population effectiveness and protective immunity of HPV vaccination in Rwandan WLWH. The propose study will provide important evidence on benefits of HPV vaccination in WLWH in the context of the World Health Organization’s call to eliminate cervical cancer.

PROJECT_TERMS: 12 year old;15 year old;Address;Adult women;Africa;Africa South of the Sahara;aged;Anogenital venereal warts;Antibodies;antibody test;Antibody titer measurement;Anus;Birth;Blood;Cancer Burden;Cancer Etiology;carcinogenicity;Cervical;cervical cancer prevention;Cervical Cancer Screening;cervicovaginal microbiome;chronic infection;Clinical;cohort;college;Colposcopy;comparison group;cost;Country;Data;Dose;Effectiveness;effectiveness study;elementary school;Enrollment;Enzyme-Linked Immunosorbent Assay;follow-up;Future;Gardasil;General Population;Generations;Genotype;girls;Goals;Health Planning;High Prevalence;High Risk Woman;HIV;HIV Infections;HIV Seronegativity;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Human papillomavirus 11;Human papillomavirus 16;Human papillomavirus 18;Human papillomavirus 6;Immune response;Immunity;Immunization Programs;Immunocompetent;immunogenicity;Impairment;Infection;innovation;Lateral;Locales;Long-Term Effects;Longitudinal Studies;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;Measures;Medical;Medicine;Methods;Military Hospitals;Natural History;Observational Study;Oral;oral infection;Outcome;Performance;point of care;point of care testing;Population;Population Study;premalignant;Prevalence;Prevention strategy;Productivity;programs;prophylactic;Prospective Studies;Prospective, cohort study;protective effect;Public Health;rare cancer;Recommendation;Reporting;Research;Resolution;Resource-limited setting;response;Risk;Risk Factors;Rwanda;Safety;Sampling;Schools;Secondary to;Sensitivity and Specificity;serosurvey;sixth grade;Specimen;Surrogate Endpoint;Target Populations;Testing;Universities;unvaccinated;Vaccinated;Vaccination;vaccine effectiveness;validation studies;virtual;Virus-like particle;Visit;Woman;Women's cohort;Women's mortality;Women's study;World Health Organization;young adult;young man;young woman


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTOLARYNGOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Here we propose to develop new technologies for retinal diagnostic imaging with optical coherence tomography. The proposed technology is faster and lower cost than current clinical systems. The high-speed and low cost will enable diagnostic imaging on a wider range of patients.

PI_NAMEs: APPLEGATE, BRIAN E. (contact);TKACZYK, TOMASZ S

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;3D Print;accurate diagnosis;adaptive optics;Adoption;Algorithms;Angiography;Clinical;clinical application;clinical imaging;commercialization;cost;Defect;design;Developing Countries;Development;Diagnostic Imaging;Diameter;Diamond;digital;Doctor of Philosophy;Early Diagnosis;Engineering;Environment;experience;fabrication;Fiber;Frequencies;General Practitioners;Human;human data;human imaging;Image;imaging system;improved;instrument;Interferometry;Labyrinth;Lasers;Lateral;Light;lithography;manufacture;Maps;Measures;meter;Microfabrication;Microscope;middle ear;Morphologic artifacts;Motion;nano;new technology;Noise;novel;novel strategies;Operative Surgical Procedures;Optical Coherence Tomography;Optics;Optometrist;Patients;pediatric patients;Performance;Phase;photonics;Population;Printing;Refractive Errors;remote sensing;Resolution;Retina;Retinal Diseases;retinal imaging;Rural;sample fixation;Sampling;Scanning;Scientist;screening;sensor;Signal Transduction;Source;Speed;standard of care;Structure;Surface;System;Techniques;Technology;technology development;Time;tissue phantom;trend;Validation;vibration;Visual;Work

PROJECT_TITLE: High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-P(81)S]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Microbiome;Prevention;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project is to conduct a prospective study in the Democratic Republic, and continue one in Rwanda, of anal and penile high-risk HPV in men who have sex with men (MSM) with and without human immunodeficiency virus (HIV) infection. The primary goal of the study is to compare and contrast the natural history of anal and penile HPV and related abnormalities, as well as the associated risk factors, in MSM from the two countries. The propose project will provide important knowledge on exposure to HPV and cancer risks in these populations and inform policy on if and what age to vaccinate these high-risk populations.

PI_NAMEs: YOTEBIENG, MARCEL  (contact)

PROJECT_TERMS: Africa South of the Sahara;Age;AIDS related cancer;Anal canal;Anatomy;Anogenital Human Papilloma Virus Infection;Antibodies;Anus;Area;Blood;cancer prevention;cancer risk;Central Africa;Cervical;Cessation of life;cohort;Collaborations;Colorectal Cancer;cost;Country;Data;Democratic Republic of the Congo;design;Developed Countries;Development;Disease;dysbiosis;Enrollment;Environment;Exposure to;follow-up;Gastrointestinal tract structure;General Population;Genotype;Goals;Grant;high risk;high risk behavior;high risk population;HIV;HIV Infections;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Immune response;Impairment;Incidence;Individual;infection rate;infection risk;Inflammatory Bowel Diseases;innovation;Investigation;Knowledge;Lesion;Link;Low Prevalence;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;malignant oropharynx neoplasm;Malignant Vaginal Neoplasm;Measures;Medical;men;men who have sex with men;microbial;microbial community;Natural History;normal microbiota;Pathogenesis;penis;Persons;Policies;Population;Populations at Risk;premalignant;Prevalence;Prevention strategy;Primary Prevention;prophylactic;Prospective Studies;rectal microbiome;Research;Resolution;Risk;Risk Factors;Rwanda;Secondary Prevention;Source;Squamous intraepithelial lesion;System;Time;Vaccinated;Vaccination;virtual;Virus Diseases

PROJECT_TITLE: Einstein/Rwanda DRC Consortium for Research in HIV/HPV Malignancies


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narative Enchondromas are common benign tumors in bone that can cause pain, deformity, be responsible for pathologic fractures, and undergo malignant degeneration to chondrosarcoma. This project will generate data to answer fundamental questions about the role of metabolism in maintaining the viability of cells in cartilaginous neoplasia. It will lay the foundation for the use of novel targeted agents to improve the clinical outcome for patients with enchondromas and chondrosarcomas, conditions for which no effective pharmacologic therapy is currently available.

PI_NAMEs: ALMAN, BENJAMIN AARON (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: alpha ketoglutarate;Animals;base;Benign;Binding Proteins;Binding Sites;bone;Bone neoplasms;cartilage development;cartilaginous;Cell Energetics;cell growth;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Cholesterol;cholesterol biosynthesis;Chondrocytes;Chondrogenic Neoplasm;Chondroma;Chondrosarcoma;Citric Acid Cycle;Clinical;Clinical Data;conditional knockout;Data;Deformity;Development;effective therapy;Enchondromatosis;Energy-Generating Resources;Enzymes;Epigenetic Process;Epiphysial cartilage;Etiology;Foundations;Gene Modified;Genes;Genetic Transcription;Glycogen;Glycogen (Starch) Synthase;Glycogenolysis Inhibition;Growth;GYS1 gene;Human;Human Cell Line;Hyperactivity;improved;In Vitro;inhibitor;Isocitrate Dehydrogenase;Isocitrates;Knockout Mice;Maintenance;Malignant - descriptor;Mediating;Mediator;Metabolic;Metabolism;Metatarsal bone structure;Molecular;Mus;mutant;Mutant Strains Mice;Mutation;Neoplasms;neoplastic;neoplastic cell;novel;novel therapeutics;overexpression;Pain;Pathological fracture;Pathology;Patient-Focused Outcomes;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;pre-clinical;prevent;Process;Production;Proliferating;Promoter Regions;Protein phosphatase;Proteins;Regulation;Regulatory Element;Role;Signal Pathway;skeletal;Somatic Mutation;Source;Sterols;targeted agent;Testing;Transcriptional Activation;tumor;Tumor Cell Line;tumor growth;tumor initiation;Work;Xenograft procedure

PROJECT_TITLE: Molecular Etiology of Enchondromatosis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Hypertension;Kidney Disease;Organ Transplantation;Prevention;Rare Diseases;Transplantation

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Americans with African ancestry sustain higher risks of progressive kidney disease after kidney donation. In this proposal we will use unique mouse models to study whether and how well-recognized mutations in the APOL1-gene, contribute to the progressive kidney disease following removal of one kidney. We will specifically focus on studying two risk factors observed in human studies - high blood pressure and activation of immune cells in our mice.

PI_NAMEs: ISHIBE, SHUTA ;MENON, MADHAV C (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Acceleration;Address;Affect;African ancestry;Age;Age Months;Albuminuria;Alleles;American;Anti-Hypertensive Agents;APOL1 gene;attributable risk;Bacterial Artificial Chromosomes;Biochemical;Biological Models;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;catalyst;Chronic;Chronic Kidney Failure;Clinical Data;cohort;Data;Development;dietary salt;differential expression;Disease;disorder risk;Disparity;Doxycycline;Epidemiology;Excision;feeding;Focal and Segmental Glomerulosclerosis;follow-up;Funding;Future;Genes;Genetic Transcription;Glomerulonephritis;Goals;Grant;hemodynamics;high risk;high salt diet;Human;human data;Hypertension;Immune;immune activation;Immunologics;improved;in vivo;Inflammatory;inflammatory milieu;Injections;insight;Interferon Type II;Kidney;kidney cell;Kidney Diseases;Kidney Transplantation;Laboratories;Lesion;Light;Living Donors;Medicare;Modeling;morphometry;mouse model;Mus;Mutation;Nephrectomy;Nephrons;novel;novel therapeutics;NPHS2 protein;Nucleic Acids;overexpression;Pathogenesis;Patients;Phenotype;Physiological;podocyte;Population;Positioning Attribute;pre-clinical;Predisposition;promoter;Proteinuria;Public Health;pure line;Renal function;Research;Risk;Risk Factors;risk variant;Role;Seminal;skills;Sodium;Sodium-Restricted Diet;Source;Systemic blood pressure;systemic inflammatory response;T-Cell Activation;Telemetry;Testing;Therapeutic;tool;Transgenic Mice;Transplantation;Variant;Viral

PROJECT_TITLE: Modelling mechanisms of progressive chronic kidney disease in APOL1 high-risk live-donors using BAC-Transgenic mice

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Facioscapulohumeral Muscular Dystrophy;Genetics;Human Genome;Muscular Dystrophy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative FSHD muscular dystrophy is one of the common muscular dystrophies with no effective treatment and its pathological mechanism remains enigmatic. The project focuses on effective disease modeling in human skeletal myocytes and dissecting the disease mechanism and disease severity/sensitivity determinants. The successful outcome of this project would not only further our understanding of FSHD biology but also lead to the potential development of novel diagnostic/therapeutic strategies.

PI_NAMEs: MORTAZAVI, SEYED ALI;YOKOMORI, KYOKO  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Affect;Area;Biological Models;Biology;Cell Death;cell killing;Cell Line;Cell Nucleus;Cells;Chromosomes;comparison control;CRISPR library;CRISPR/Cas technology;cytotoxic;cytotoxicity;D4Z4;Data;Defect;Detection;Development;Disease;disease model;disease phenotype;Disease Progression;Disease susceptibility;DNA Sequence Alteration;effective therapy;Epigenetic Process;Exhibits;Facioscapulohumeral;Facioscapulohumeral Muscular Dystrophy;Funding;Gene Activation;Gene Expression;gene network;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetic Transcription;genome-wide;Grant;Heterogeneity;Human;In Situ;In Situ Hybridization;In Vitro;Individual;induced pluripotent stem cell;insight;Investigation;Link;model organism;Modeling;mouse genome;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle progenitor cell;Muscular Dystrophies;mutant;Mutation;Myoblasts;myogenesis;nanopore;new therapeutic target;novel diagnostics;Outcome;overexpression;Pathogenesis;Pathogenicity;Pathologic;Patients;PAX7 gene;Phenotype;Play;Primates;Process;quadriceps muscle;Regulation;RNA;Role;Sampling;screening;Severity of illness;small hairpin RNA;stem cells;Stimulus;System;Therapeutic;Time;transcription factor;transcriptome;transcriptome sequencing

PROJECT_TITLE: Genetic and epigenetic mechanisms of FSHD pathogenesis

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stem Cell Research - Umbilical Cord Blood/ Placenta;Stem Cell Research - Umbilical Cord Blood/ Placenta - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Hematopoietic Stem Cells (HSCs) are the functional units of therapeutic bone marrow transplantation. A major goal of hematology research is in vitro expansion of HSCs from umbilical cord blood and other sources to boost stem cell numbers for transplantation, gene transfer and gene editing. Strategies for HSC expansion typically entail co-culture with supportive cell types to recapitulate the hematopoietic microenvironment, or niche, which regulates HSC maintenance, self-renewal, and differentiation. We propose to generate a most comprehensive single cell atlas of the ecosystem of embryonic hematopoiesis. Elucidating the molecular identity of niche cells, specifying their derivation both in vitro and in vivo through the recreation of synthetic niches, and understanding the cell-cell communication that underlies niche interactions with HSPCs is an important goal that has enormous promise to impact ex vivo culture, expansion, and genetic manipulation of HSCs for experimental and therapeutic applications.

PI_NAMEs: COLLINS, JAMES J;DALEY, GEORGE Q (contact);NORTH, TRISTA E.;ZON, LEONARD IRA

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adipocytes;Adult;Algorithms;Anatomy;Aorta;ATAC-seq;Atlases;Blood;Bone Marrow;Bone Marrow Transplantation;Cataloging;Catalogs;Cell Adhesion Molecules;Cell Communication;Cell Count;Cell Differentiation process;Cell Line;Cell Maintenance;Cell surface;cell type;Cells;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Code;Collaborations;Communities;Computational algorithm;computational pipelines;Computer software;critical period;Data;data resource;Data Set;Derivation procedure;Development;Dimensions;directed differentiation;DNA Binding;DNA cassette;Ecosystem;Elements;Embryo;Embryonic Development;Endothelial Cells;Endothelium;Engineering;Equilibrium;fetal;Fetal Liver;Fishes;gene discovery;Gene Expression;Gene Expression Profile;Gene Modified;gene regulatory network;Gene Transfer;gene-editing approach;Generations;Genes;genetic manipulation;Genetic Transcription;Glean;Goals;Gonadal structure;Hematology;Hematopoiesis;Hematopoietic;hematopoietic differentiation;hematopoietic stem cell emergence;hematopoietic stem cell expansion;hematopoietic stem cell fate;hematopoietic stem cell niche;Hematopoietic Stem Cell Specification;Hematopoietic stem cells;hemogenic endothelium;Homing;Human;In Situ Hybridization;In Vitro;in vivo;innovation;insight;intercellular communication;knock-down;Learning;Life;Location;Macrophage;Mammals;Mesenchymal;Mesonephric structure;migration;Mining;Modeling;Molecular;Mouse Strains;Mus;Neural Crest;novel;open source;Placenta;Pluripotent Stem Cells;Population;Pregnancy;programs;Recreation;recruit;Reporter;Reporting;Research;Research Personnel;Resolution;Resources;self-renewal;Shapes;Signal Transduction;single-cell RNA sequencing;Site;Somites;Source;Specific qualifier value;stem cell migration;stem cell niche;stem cells;synthetic biology;synthetic construct;System;Techniques;Testing;Therapeutic;transcriptome sequencing;translational applications;Transplantation;Umbilical Cord Blood;user-friendly;web site;Work;Zebrafish

PROJECT_TITLE: Molecular Circuits in the Hematopoietic Stem Cell Niche


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: HUNTER COLLEGE

PHR: Relevance Statement Alzheimer’s disease (AD) is a triple threat – with soaring prevalence, enormous costs and lack of effective treatment. However, AD is a complex disease that has been extremely hard to treat with the conventional approach. New methods that can reuse old drugs to target mulple pathological processes in AD may provide new solutions to effective AD treatment.

PI_NAMEs: XIE, LEI  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Address;Alzheimer disease prevention;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapy;Amyloid beta-Protein;Animal Model;Artificial Intelligence;Binding;Bioinformatics;bioinformatics resource;Biophysics;Brain;Cell Line;cell type;Cells;Chemicals;Classification;Clinic;Clinical Trials;Communities;Complex;computer framework;Computing Methodologies;Consensus;cost;Darkness;Data;Databases;deep learning;Development;Disease;disease model;drug action;drug candidate;drug development;drug discovery;Drug Kinetics;Drug Modelings;drug repurposing;Drug Targeting;Drug toxicity;effective therapy;Effectiveness;Failure;Gene Expression;Genes;genome wide association study;genome-wide;Graph;Heterogeneity;Human;hyperphosphorylated tau;improved;individual patient;Inflammation;insight;Knowledge;Lead;lead optimization;Ligands;Link;Machine Learning;Methodology;Methods;Mining;Modeling;Modernization;Molecular;Multiomic Data;network models;Network-based;novel;novel therapeutic intervention;novel therapeutics;Pathogenicity;Pathologic;Pathologic Processes;Pathway interactions;patient stratification;Patients;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Pharmacology;Phase;Phenotype;physiologically based pharmacokinetics;precision medicine;Prevalence;Process;Property;Proteins;Public Health;response;screening;side effect;success;System;Systems Biology;Techniques;Testing;therapeutically effective;Tissues;Toxic effect;transcriptome;transcriptome sequencing;Translating

PROJECT_TITLE: AI-Powered Quantitative Systems Pharmacology for AD Drug Repurposing


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Socio-affective dysfunction underlies myriad neuropsychiatric diseases; prior efforts to develop neuromodulation paradigms for treatment-resistant cases of neuropsychiatric diseases characterized by socio- affective dysfunction have fallen short, in part due to an absence of defined neural dysfunctional-state signals. The overall goal of this R01 proposal is to map the spatiotemporal dynamics of social affective processing and to examine selective modulation of these dynamics in humans undergoing invasive intracranial monitoring for treatment-resistant epilepsy and depression. We leverage first-in-human intracranial neural recording opportunities created by a novel therapeutic platform termed “stereotactic electroencephalography-informed deep brain stimulation” (stereo-EEG-informed DBS; Parent Study UH3-NS103549), as well as the powerful platform of intracranial stereotactic recording and stimulation in patients undergoing epilepsy surgical evaluation to establish the precise structural, functional, and causal properties of the affective salience network as a circuit substrate underlying social processing.

PI_NAMEs: BIJANKI, KELLY ROWE (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Affect;Affective;Amygdaloid structure;Anterior;Anxiety Disorders;Architecture;area striata;autism spectrum disorder;behavior measurement;Behavioral;brain behavior;burden of illness;Categories;cingulate cortex;cognitive task;cohort;college;Communication;Corpus striatum structure;Data;Deep Brain Stimulation;Depressed mood;Depressive disorder;depressive symptoms;Diagnostic;diffusion weighted;Electrodes;Electroencephalography;Electrophysiology (science);Emotional;emotional functioning;emotional stimulus;Epilepsy;Etiology;Evaluation;Evoked Potentials;Face;Face Processing;Facial Expression;Failure;Feeling;Feeling hopeless;first-in-human;Functional disorder;fusiform face area;Goals;Human;improved;indexing;innovation;Maps;Mediating;Medicine;Mental Depression;Methodology;Monitor;Mood Disorders;Moods;Motor Activity;Negative Valence;network dysfunction;neural;neuroimaging;neuropsychiatric disorder;neuropsychiatry;neuroregulation;Noise;novel;novel therapeutics;Operative Surgical Procedures;Parents;Patient Self-Report;Patients;Pattern;Physiologic pulse;positive mood;Process;Production;Property;Reporting;Research Domain Criteria;Resistance;response;Rest;Role;Signal Transduction;social;social cognition;Social Environment;Social isolation;spatiotemporal;Structure of superior temporal sulcus;Symptoms;System;temporal measurement;Therapeutic;treatment-resistant depression;white matter

PROJECT_TITLE: Mapping and Modulating the Spatiotemporal dynamics of socio-affective processing.


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Congenital Structural Anomalies;Genetics;Neurosciences;Nutrition;Obesity;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Understanding the functioning of weight regulation is critically important to stem the growing prevalence of obesity and meet the urgent need for therapies. Study of rare diseases has informed our knowledge about the mechanisms for energy homeostasis. This proposal aims to expand this understanding by defining the role of a potential new gene with a role in the central weight regulatory pathway.

PI_NAMEs: THAKER, VIDHU V. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: 3 year old;Address;adenovirus mediated delivery;Adhesions;Adult;Affect;Agonist;Alleles;Alstrom syndrome;Animal Model;Animals;ASPM gene;Automobile Driving;Bardet-Biedl Syndrome;Behavioral;behavioral impairment;Biological Assay;Biological Models;Body mass index;Body System;Body Weight;Brain;Brothers;C-terminal;C57BL/6 Mouse;Cell Line;Cell membrane;Cells;Child;Childhood;Cilia;ciliopathy;cilium biogenesis;Clathrin;Clinical;Cognitive;conditional knockout;congenital cataract;CRISPR/Cas technology;Cytoskeleton;Data;Disease;DNA;early childhood;Endosomes;energy balance;Epilepsy;Eukaryotic Cell;Exons;Family;FDA approved;Fibroblasts;Frameshift Mutation;Functional disorder;Future;Gene Expression;gene network;Genes;Genetic;Growth;Height;High Fat Diet;Homeostasis;Human;human model;humanized mouse;Hyperphagia;Hypothalamic structure;Hypoventilation;In Vitro;in vivo;induced pluripotent stem cell;Inherited;inorganic phosphate;Inositol;inositol-1,4,5-trisphosphate 5-phosphatase;Insulin;Kidney;knock-down;knockout gene;Knockout Mice;Knowledge;Lead;Length;Leptin;Link;Lipids;loss of function;Lysosomes;male;Measurement;Measures;Mediating;Melanocortin 4 Receptor;Membrane;metabolic phenotype;Modeling;Molecular Biology;Morbid Obesity;Morphology;Mothers;mouse model;Mus;mutant;Mutation;N-terminal;Neuronal Differentiation;Neurons;Neuropeptides;Neurosecretory Systems;novel;Obesity;Obesity Epidemic;obesity in children;Oculocerebrorenal Syndrome;Online Mendelian Inheritance In Man;Organelles;Overweight;paraventricular nucleus;Pathway interactions;Patients;PH Domain;Phenotype;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Positioning Attribute;postnatal;Prevalence;Pro-Opiomelanocortin;proband;Production;protein function;Protein Isoforms;Proteins;Protocols documentation;Rare Diseases;receptor;Regulation;Regulatory Pathway;response;Rest;rho GTP-Binding Proteins;RNA Interference;Role;Satiation;Sensory;Series;Siblings;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Somatotropin-Releasing Hormone;stem;Structure;Structure of nucleus infundibularis hypothalami;Syndactyly;Syndrome;Testing;therapeutic target;Time;Tissues;Toes;trafficking;trans-Golgi Network;Transcript;transcriptome sequencing;Variant;Weight;Zebrafish;α-Melanocyte stimulating hormone

PROJECT_TITLE: Establishing the role of OCRL as a novel ciliary gene in weight regulation in human and murine models

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

PHR: Project Narrative Tuberculosis (TB) remains a worldwide problem despite the availability of a vaccine and pharmacopeia, due to the ability of Mycobacterium tuberculosis, the causative agent of TB, to resist sterilization in mammals also known as persistence. The goal of this proposal is to uncover genes implicated in this phenomenon whose deletion would result in elimination of the persister population and sterilization of M. tuberculosis. Furthermore, unmasking M. tuberculosis in vitro and in vivo persistence mechanisms could lead to novel chemotherapies, vaccine development and immunotherapies.

PI_NAMEs: JACOBS, WILLIAM ROBERT (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: adaptive immune response;adaptive immunity;Affect;Amikacin;amino acid metabolism;Amino Acids;Anabolism;Antibiotics;Ascorbic Acid;Bacterial Chromosomes;bactericide;Bacteriocides;Bar Codes;BCG Live;Cause of Death;cell killing;Cell Survival;Cells;Cessation of life;chemotherapy;Chromosome Structures;Chromosomes;COVID-19;Cysteine;Data;Defect;Engineering;Gene Deletion;Genes;Genetic;genetic analysis;Genetic Determinism;Genus staphylococcus;Goals;Growth;Heritability;Hypoxia;Immune;Immune response;Immunocompetent;Immunocompromised Host;immunodeficiency;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infectious Agent;insight;isoniazid;Isoniazid resistance;Leucine;Maintenance;Mammals;Mediating;Metabolic;Metabolic Pathway;Metabolic Pathways of Other Amino Acids;Methionine;Microarray Analysis;Modeling;Molecular Genetics;Monitor;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mycobacterium tuberculosis;novel;Nutrient;overexpression;Pantothenic Acid;Pathway interactions;Penicillins;Pharmaceutical Preparations;Pharmacopoeias;Phase;Phenotype;Physiological;Play;Population;Positioning Attribute;Predisposition;prevent;Principal Investigator;Proteins;Rag1 Mouse;Reporter;Reproducibility;Resistance;Role;Starvation;Sterilization;Streptococcus;Stress;Testing;tool;transcriptome sequencing;Tuberculosis;tuberculosis drugs;tuberculosis treatment;vaccine development;vaccine immunotherapy;Vaccines;Wild Type Mouse

PROJECT_TITLE: Molecular Genetic Analysis of Mycobacterium Tuberculosis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Brain metastasis remains a major cause of morbidity and mortality in patients with cancer, which urgently needs effective therapeutic strategies. Our preliminary studies revealed that fibroblasts support the growth of brain metastasis, by protecting cancer cells from chemotherapeutic treatment and inducing immunosuppression in the brain. Here we propose to investigate the mechanisms underlying the supportive role of fibroblasts in brain metastasis, and test the therapeutic potentials of targeting fibroblasts in the treatment of brain metastasis.

PI_NAMEs: YANG, ZENG-JIE  (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Adult;Antibodies;Behavior;Brain;brain tissue;cancer cell;Cancer Patient;Cell Proliferation;cell type;Cells;Chemoresistance;chemotherapy;Clinical Trials;Coculture Techniques;cytokine;Data;Disease;Environment;experimental study;Fibroblasts;gain of function;Genes;Genetic;Growth;Human;Immune;immune cell infiltrate;Immune Evasion;Immune system;Immunocompromised Host;Immunosuppression;In Vitro;in vivo;Infiltration;insight;Interleukin-10;Intervention;Intracranial Neoplasms;knock-down;loss of function;lung cancer cell;Lymphocyte;Macrophage;Macrophage Activation;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Messenger RNA;Metastatic malignant neoplasm to brain;Morbidity - disease rate;mortality;mouse model;Mus;Mutant Strains Mice;Neoplasm Metastasis;Neuropilin-1;neutralizing antibody;Pathogenesis;Patients;Penetration;PGF gene;Pharmacologic Substance;Phenotype;Phosphorylation;PIK3CG gene;Play;preclinical study;Primary Brain Neoplasms;Proliferating;receptor;Repression;Resistance;Role;Signal Transduction;single-cell RNA sequencing;Source;Testing;Therapeutic;therapeutic evaluation;Therapeutic Uses;therapeutically effective;Transforming Growth Factor beta;Transplantation;tumor microenvironment;tumor-immune system interactions;Tyrosine Kinase Inhibitor;Vertebral column

PROJECT_TITLE: Fibroblasts Support the Growth of Brain Metastasis by Rendering Cancer Cells Resistant to Chemotherapy and Inducing Immunosuppression in Tumor Microenvironment


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Recent advances in natural language processing and machine learning offer a unique opportunity to explore highly complex changes in connected speech in the preclinical and prodromal stages of Alzheimer's disease (AD). This study investigates the accuracy and diagnostic performance of non-invasive digital biomarkers in detecting and predicting AD biomarker status in individuals with normal cognition or mild cognitive impairment. It is anticipated that the findings of this project will improve the ability to detect and track longitudinal changes in the cognitive and functional status in AD.

PI_NAMEs: HAJJAR, IHAB M (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Acoustics;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Applications Grants;Area Under Curve;Artificial Intelligence;Autobiography;automated speech recognition;Autopsy;Biological Markers;biomarker signature;Brain;Categories;cerebral atrophy;Cerebrospinal Fluid;Classification;Clinical;clinical decision-making;Cognition;Cognitive;cognitive testing;cohort;Complex;Consumption;Data;Dementia;density;Development;Diagnosis;Diagnostic;diagnostic accuracy;Digital biomarker;digital measure;Disease;Disease Progression;early detection biomarkers;Early identification;follow-up;Foundations;Framingham Heart Study;functional status;Future;hippocampal atrophy;Hippocampus;Hypertension;Image;Impaired cognition;Impairment;improved;in vivo;Individual;innovation;insight;late life;lexical;Light;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Methodology;Methods;mild cognitive impairment;National Institute on Alcohol Abuse and Alcoholism;Natural Language Processing;Nerve Degeneration;Neurofibrillary Tangles;neurofilament;neuroimaging;neuropathology;Neuropsychology;novel;Online Systems;Participant;Pathologic;Performance;Phase;Phenotype;Phonetics;Positron-Emission Tomography;pre-clinical;Predictive Value;programs;Reporting;Research;Scanning;Semantics;smartphone application;Specificity;Speech;Spinal Puncture;Stress;success;Sum;Symptoms;tau Proteins;tau-1;technology validation;Testing;Time;tool;Voice;Weight;Work

PROJECT_TITLE: Digital Biomarkers for Alzheimer’s Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: American Indian or Alaska Native;Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health

PHR: This re-competition application describes the previous experience of our multidisciplinary group in conducting  early Phase clinical trials of experimental cancer therapeutics and related correlative translational science  studies through the National Cancer Institute Experimental Therapeutics-Clinical Trials Network (ETCTN). It  details the continued plans of our consortium to perform comprehensive conduct of early clinical trials, more  selective and sophisticated clinical and translational investigational strategies, and seamless advancement of  experimental agents through early stages of development. Finally, it highlights our prioritization for mentoring  the next generation of cancer clinical trialists and describes opportunities for them to develop their leadership  and educational skillsets.

PI_NAMEs: LORUSSO, PATRICIA M. (contact)

PROGRAM_OFFICER_NAME: IVY, S PERCY

PROJECT_TERMS: Acceleration;Amendment;American Indians;Antineoplastic Agents;Area;Award;Back;bench to bedside;Biological Assay;Biological Markers;Biology;biomarker driven;California;Cancer Center;cancer clinical trial;Cancer Patient;Cancer Therapy Evaluation Program;career;Catchment Area;Clinic;Clinical;clinical investigation;Clinical Investigator;Clinical Research;clinical trial recruitment;Clinical Trials Network;Collaborations;Data;design;Development;Discipline;Disease;Drug Delivery Systems;drug development;Drug Kinetics;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;Education;Eligibility Determination;Evolution;experience;Faculty;Funding;Generations;Genomics;Geography;Goals;Health Service Area;Histologic;imaging biomarker;Immunology;Immunotherapy;improved outcome;Infrastructure;Institution;Investigation;Investigational Therapies;Knowledge;Laboratories;Leadership;Letters;Malignant Neoplasms;member;Mentors;Mentorship;Methods;Minority Groups;Mission;Molecular;Monitor;multidisciplinary;National Cancer Institute;next generation;novel;novel anticancer drug;novel marker;novel therapeutic intervention;novel therapeutics;Oklahoma;Oncology;patient biomarkers;patient population;Patient Recruitments;Patient Selection;patient subsets;Patient-Focused Outcomes;Patients;Pharmacodynamics;Pharmacopoeias;Phase;phase II trial;Philosophy;Population;Protocols documentation;rare cancer;recruit;Reporting;Research;Research Design;Research Personnel;Resistance;resistance mechanism;response;rural Americans;Rural Population;Science;Serum;Services;Site;skills;Special Population;Stratification;student mentoring;Testing;Therapeutic;tissue biomarkers;tool;Toxic effect;Training;Translating;translational medicine;Translational Research;Translations;treatment optimization;trial design;tumor;Universities;Variant;Work;Yale Cancer Center

PROJECT_TITLE: VICKtOrY Early Clinical Trials Consortium


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_DEPT: PHYSIOLOGY

PHR: NARRATIVE The proposal focuses on understanding the molecular mechanisms of L-type calcium channel regulation in heart cells. The studies have potential to provide deepened insights into the molecular basis of cardiovascular diseases and lead to development of better therapies for these diseases.

PI_NAMEs: COLECRAFT, HENRY M. (contact);MARX, STEVEN O

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Adrenergic Agents;Adrenergic beta-Agonists;ascorbate;Automobile Driving;Binding;calyculin;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell membrane;cell type;combat;Coupling;Cyclic AMP-Dependent Protein Kinases;Data;Development;Dimensions;Disease;Echocardiography;Electrostatics;Engineering;Equilibrium;Exposure to;fighting;Flow Cytometry;Fluorescence Resonance Energy Transfer;Funding;Gene Expression;Health;Heart;heart cell;Heart Diseases;Heart failure;Hydrophobicity;Infection;inhibitor;innovation;insight;knock-down;Knock-in Mouse;L Cells;L-Type Calcium Channels;Label;Libraries;Macromolecular Complexes;Mediating;Methods;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;mutant;Mutate;Myocardial Ischemia;nano;nanobodies;novel;patch clamp;Peroxidases;pharmacologic;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Physiology;Protein Inhibition;Protein phosphatase;protein purification;Proteomics;Protocols documentation;recruit;Regulation;Reporting;response;Role;Sarcolemma;Signal Transduction;Small Interfering RNA;Tail;trafficking;Transgenic Mice;Up-Regulation;voltage;Yeasts

PROJECT_TITLE: L-type channel trafficking and modulation in heart

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Genetics;Pediatric

ORG_CITY: SAINT LOUIS

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: HEALTH RELEVANCE  The groove of Ranvier (GOR) is a histologically defined structure adjacent to the growth plate that is thought to harbor skeletal stem cells and signaling cells. The GOR is of interest to clinicians as it is located at the site of distal femoral physeal fractures (Salter-Harris type II) that occur in children and that can severely impair bone growth. Our proposed studies will provide new genetic tools to study the GOR and potential therapeutic insight that could be used to prevent growth arrest associated with physeal fractures.

PI_NAMEs: ORNITZ, DAVID M (contact)

PROJECT_TERMS: Affect;Alleles;Anatomy;Applications Grants;biomarker identification;bone;Bone Growth;capsule;Cell Lineage;Cell Physiology;Cell Separation;Cell surface;Cells;Characteristics;Child;Childhood;Chondrocytes;Chondrogenesis;Clinical;Data;Development;Distal;Doxycycline;Dwarfism;Embryo;embryo cell;Embryonic Development;Engineering;Epiphysial cartilage;Feedback;Femur;FGF9 gene;FGFR1 gene;FGFR3 gene;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Foundations;Fracture;Future;Genetic;genetic signature;Growth;Growth Factor;Health;Histologic;Impairment;In Situ Hybridization;insight;interest;Knowledge;Label;Ligands;Link;Location;Mus;Osteoblasts;Osteogenesis;Pathogenesis;Phenotype;Physiological;Population;postnatal;Pregnancy;preservation;prevent;Proliferating;Property;Receptor Signaling;Regulation;Signal Transduction;single cell mRNA sequencing;Site;Skeletal Development;skeletal stem cell;Sorting;Stromal Cells;Structure;Therapeutic;Tissues;Tomatoes;tool;Transgenes;Vascular blood supply

PROJECT_TITLE: Identification of an FGF-regulated signaling center in the Groove of Ranvier that controls longitudinal bone growth.


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Ovarian Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Ovarian cancer is a deadly disease, but survival varies widely by race/ethnicity. We propose to examine whether differences in neighborhood characteristics, patient and clinical factors including receipt of recommended treatments, or molecular features of the tumors can account for these disparities, at least in part. Ovarian cancer is understudied in diverse populations, and the proposed work is one of the largest to search for potentially modifiable factors that can reduce disparities in survival.

PI_NAMEs: BANDERA, ELISA V;DOHERTY, JENNIFER A. (contact);GOMEZ, SCARLETT L;KUSHI, LAWRENCE H

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: Accounting;Address;Adherence;African American;African American Women;Age;Annual Reports;Area;Asian;Asian population;Attenuated;Biological;Biological Factors;Body mass index;California;cancer diagnosis;Cancer Etiology;cancer subtypes;cancer survival;cancer therapy;Caring;Cells;Characteristics;chemotherapy;Classification;Clinical;Clinical Data;clinical database;Clinical Management;Clinical Pathology;cohort;Cohort Studies;comorbidity;Complex;Comprehensive Health Care;contextual factors;Crime;Data;Diagnosis;Diagnostic;Disease;Disparity;disparity reduction;Dose;Electronics;Epithelial ovarian cancer;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Evaluation;Exclusion;experience;Gene Expression;Gene Expression Profile;Genetic;Geographic Factor;Geography;Goals;Guidelines;health care availability;health care service;Health Insurance;Health Services Accessibility;Healthcare;Healthcare Systems;Hispanic;Hispanic Populations;Hispanic Women;improved;Inequity;insight;Insurance Coverage;Integrated Health Care Systems;Malignant neoplasm of ovary;Malignant Neoplasms;Managed Care;Medical;Medical Geography;member;Minority Groups;Molecular;molecular subtypes;Morphology;mortality;mortality disparity;mortality risk;multi-ethnic;Nature;Neighborhoods;Not Hispanic or Latino;novel;Outcome;Pacific Islander;Participant;Pathology;Patient Self-Report;Patients;Physicians;Policies;Population Heterogeneity;prognostic;Prospective, cohort study;protein expression;Race;racial determinant;racial difference;racial disparity;Recommendation;Recurrence;Reporting;Research;residence;Residual Neoplasm;Resources;Sample Size;segregation;Serous;social;social factors;social stressor;Social support;Societies;sociodemographics;Socioeconomic Status;Specimen;standard of care;Stress;Structural Racism;survival disparity;survival outcome;Time;Toxic effect;treatment guidelines;Treatment outcome;treatment response;tumor;Underserved Population;United States;White Women;Woman;women's diagnosis;Women's mortality;Work;World Health Organization

PROJECT_TITLE: Racial/Ethnic Disparities in Ovarian Cancer Treatment and Survival: An Integrative Approach

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Complementary and Integrative Health;Digestive Diseases;Hepatitis;Liver Disease;Nutrition;Physical Activity;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States and it increases the risk of cirrhosis, hepatocellular carcinoma, and cardiometabolic diseases. The proposed research will define how liver ketogenesis actively supports fat breakdown in the tricarboxylic acid cycle and show that loss of this beneficial coupling contributes to the pathological progression of NAFLD. This improved understanding of how mitochondrial pathways coordinate fat disposal will inform new interventions to prevent and treat NAFLD.

PI_NAMEs: HUGHEY, CURTIS  (contact)

PROGRAM_OFFICER_NAME: GARCIA, MARTHA

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acute;Adult;beta-Hydroxybutyrate;Biological Assay;Cardiometabolic Disease;Catabolism;Cell Respiration;Chronic;chronic liver disease;Cirrhosis;Citric Acid Cycle;Coupling;Data;Diet;Disease;Disease Management;Disease stratification;Enzymes;Exercise;exercise training;Exhibits;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Fluorometry;Free Radicals;Health;Hepatic;Heterogeneity;High Fat Diet;Human;Human Characteristics;Impairment;improved;in vivo;indexing;Inflammation;innovation;Intervention;islet amyloid polypeptide;Isotopes;ketogenesis;ketogenic diet;ketogentic;Ketone Bodies;Ketones;knock-down;Knockout Mice;Knowledge;Lead;Lecithin;Lipids;Liver;Liver diseases;liver injury;Liver Mitochondria;Metabolic;metabolomics;Methods;Mitochondria;Molecular;mouse model;Mus;NADH;Nicotinamide N-Methyltransferase;nicotinamide riboside supplementation;nicotinamide-beta-riboside;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel therapeutics;Nutrient;Outcome;oxidation;Oxidative Phosphorylation;Oxidative Stress;Oxidoreductase;Pathologic;Pathway interactions;Phenotype;Phosphatidylethanolamine N-Methyltransferase;preservation;prevent;Primary carcinoma of the liver cells;Production;Protocols documentation;Public Health;Research;response;Rest;Risk;Running;Severity of illness;Signal Transduction;Spirometry;Steatohepatitis;Testing;treadmill;United States;Wild Type Mouse;Work

PROJECT_TITLE: Hepatic Integration of Mitochondrial Oxidative Metabolism Pathways in Health and Disease

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AUGUSTA

ORG_DEPT: PATHOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: Targeting CD44 signaling in regulating glioblastoma stemness and immune response Project Narrative: Glioblastoma multiforme (GBM) is usually resistant to standard-of-care treatments including chemotherapy and radiotherapy. In the proposed study, we aim to mechanistically investigate how the oncolytic virus oHSV-CD44 modulates the CD44 signaling in GBM microenvironment. We will test the hypothesis that oHSV-CD44 can modulate tumor CD44 signaling to inhibit the stemness of glioblastoma stem cells, enhance the anti-tumor immune response, and sensitize tumor cells to AKT inhibitors or radiotherapy.

PI_NAMEs: HONG, BANGXING B (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: adaptive immune response;Address;Affect;AKT inhibition;anti-tumor immune response;Area;Binding;Brain Neoplasms;CD44 gene;Cell Physiology;Cells;chemotherapy;Chemotherapy and/or radiation;Cytolysis;experimental study;Extracellular Domain;Extracellular Matrix;FDA approved;Glioblastoma;Glucose;Grant;Growth;Herpesvirus 1;Hyaluronic Acid;Immune;immune cell infiltrate;Immune response;immunoregulation;Immunosuppression;improved;in vivo;Infection;inhibitor;inhibitor therapy;Injections;Innate Immune Response;irradiation;Japan;Ligands;Light;MAP Kinase Gene;Marketing;Mediating;neoplastic cell;nestin protein;Neurosphere;novel;Oncolytic;oncolytic herpes simplex virus;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;osteopontin;patient prognosis;Patients;Prognosis;Proteoglycan;Proto-Oncogene Proteins c-akt;Radiation therapy;Regimen;Relapse;Research;Resistance;Role;Signal Transduction;Simplexvirus;Solid Neoplasm;standard of care;stem cells;stemness;Testing;treatment strategy;tumor;tumor microenvironment;tumor xenograft;Virus;Xenograft procedure

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_DEPT: MISCELLANEOUS

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: NARRATIVE Staphylococcus aureus and several viruses often infect the skin of patients with atopic dermatitis, a chronic inflammatory skin condition. This project will identify immune mechanisms that restrict these pathogens and contribute to skin disease. An improved understanding of such pathways may underpin the development of preventive and therapeutic strategies.

PI_NAMEs: JENSEN, LISELOTTE E (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Acute;Affect;antagonist;Anti-Inflammatory Agents;antimicrobial;Atopic Dermatitis;Bacterial Infections;Cell Culture Techniques;cell type;Cells;Chronic;chronic inflammatory skin;clinically significant;conditional knockout;Conflict (Psychology);cytokine;Data;Dendritic Cells;Dermis;Development;Disease;draining lymph node;Epidermis;experimental study;Fibroblasts;Future;Genes;Health;Herpes Simplex Infections;Herpesviridae;Herpesvirus 1;Herpesvirus Type 3;Hospitalization;Human;ICAM1 gene;IL17 gene;Immune;Immune response;Immune System Diseases;Immunity;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Infection;Infectious Skin Diseases;Infiltration;Inflammation;Inflammatory;insight;Interferons;Interleukin-1;Interleukin-1 Receptors;Interleukins;keratinocyte;Knockout Mice;Knowledge;Langerhans cell;Lesion;LoxP-flanked allele;Macrophage;Modeling;monocyte;mouse model;Mouse Strains;Mus;pathogen;pathogenic microbe;Pathway interactions;Patients;Physiological;Play;polarized cell;Population;Positioning Attribute;Preventive;promoter;Publishing;Quality of life;receptor;receptor expression;Reporter;Reporter Genes;Research;response;Risk;Role;Signal Transduction;Simplexvirus;Skin;Skin colonization;skin disorder;Staphylococcus aureus;System;T-Lymphocyte;Therapeutic;Time;transcriptome sequencing;treatment response;Up-Regulation;Viral Load result;Virus;Virus Diseases

PROJECT_TITLE: Dynamic interplay between IL-36 and IL-1 in inflammation and infections

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Identification apoptosis is critical to monitoring neoadjuvant chemotherapy response for breast cancer utmost importance. This proposal seeks to develop a new optoacoustic reporter dye and biosensor to identify apoptosis (SAB) using Multispectral Optoacoustic (photoacoustic) imaging to improve detection and monitoring of neoadjuvant chemotherapy.

PI_NAMEs: HENARY, MAGED M;MCNALLY, LACEY R (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Adjuvant Chemotherapy;Antitumor Response;Apoptosis;Biodistribution;Biopsy;Biosensor;Breast Cancer Patient;Breast Cancer Treatment;Breast Oncology;cancer care;Cancer Patient;cancer therapy;Cell Death;Cells;Chemistry;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical decision-making;clinical examination;Computer Models;Contrast Media;Detection;Development;Disease;Dose;Drug Kinetics;Dyes;Engineering;Extinction;extracellular;FDA approved;Goals;Human;Image;Imaging technology;improved;In complete remission;In Vitro;in vivo;individualized medicine;Induction of Apoptosis;Investigation;Ionizing radiation;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammary Neoplasms;Molecular;Molecular Biology;Monitor;Morbidity - disease rate;near infrared dye;Neoadjuvant Therapy;neoplastic cell;Non-Malignant;novel;novel therapeutics;Operative Surgical Procedures;Optics;optoacoustic tomography;Pathway interactions;Patients;Penetration;Peptides;Performance;personalized medicine;Pharmaceutical Preparations;photoacoustic imaging;pre-clinical;Property;prototype;quantum;rational design;Reporter;response;Sampling;Schedule;Sensitivity and Specificity;Signal Transduction;Specificity;squaraine;success;System;Techniques;Testing;Time;Tissue Sample;Tissues;Toxic effect;treatment response;tumor;uptake;Visit;Visualization;Work

PROJECT_TITLE: Development of an apoptosis biosensor for monitoring of breast cancer

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Infant Mortality;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Given the impressive mortality rate of pediatric patients with cardiac outflow tract (OFT) defects, there remains a critical need to improve medical and surgical strategies through precise delineation of the cellular, molecular, and biomechanical mechanisms responsible for OFT formation. Our studies illuminate Fibulin proteins, previously unappreciated ECM factors involved in OFT development, as critical regulators of TGF-β signaling and elastogenesis in the bulbous arteriosus. We anticipate that our innovative model characterizing the importance of ECM microenvironment in the evolution of OFT defects will fuel further identification of novel genes associated with congenital heart disease.

PI_NAMEs: TARGOFF, KIMARA L (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Adrenergic Agents;Agonist;Arteries;Biomechanics;Biophysical Process;Blood flow;Caliber;Cardiac;cardiogenesis;Cell Differentiation process;cell type;cohort;Complex;Congenital Abnormality;congenital heart abnormality;conotruncal heart defect;constriction;Cues;Data;Death Rate;Defect;Deposition;Development;Dimensions;Disease;Distal;Double Outlet Right Ventricle;Elastic Fiber;Elasticity;Elastin;Elastin Fiber;Elements;Embryo;Endothelial Cells;Etiology;Evolution;Exhibits;Extracellular Matrix;Extracellular Matrix Proteins;FBLN5 gene;Feedback;Fibronectins;fibulin;Foundations;gain of function;Gene Family;Genes;Genetic;Glycoproteins;Growth;Heart Diseases;Heart Valve Prosthesis;Human;Impairment;improved;in vivo;Individual;Infant Mortality;Influentials;innovation;insight;Lead;Liquid substance;loss of function;malformation;mechanotransduction;Mediating;Medical;migration;Modeling;Modulus;Molecular;Morphogenesis;mutant;new therapeutic target;novel;novel therapeutics;Operative Surgical Procedures;Pathway interactions;Patients;pediatric patients;Piezo 1 ion channel;Population;Proliferating;protein function;Proteins;Protocols documentation;Reporting;Role;Secondary to;Severity of illness;shear stress;Signal Transduction;Smooth Muscle Myocytes;Stenosis;Stimulus;Structure;Testing;Tetralogy of Fallot;Tissue Engineering;Tissues;Titrations;Transforming Growth Factor beta;Transposition of Great Vessels

PROJECT_TITLE: Mechanisms of outflow tract morphogenesis regulated by extracellular matrix

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Patient Safety;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: The medicinal use of cannabis has been legalized widely without much evaluation of patient-level outcomes to determine the health effects, positive or negative, of this policy change. This project will include the establishment of a national patient research registry, a cannabis product surveillance and testing program, a program of evaluating patient electronic medical records and a data repository to integrate data from other sources with those collected as part of these initiatives. The data collected and made available to researchers and the public will help inform clinical decision-making about the medicinal use of cannabis as well as help steer policy and regulatory decisions in the interest of public and patient health.

PI_NAMEs: THRUL, JOHANNES ;VANDREY, RYAN G (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: abuse liability;Adverse event;Advertising;Advocate;alternative treatment;American;Archives;Area;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;Caring;Case Study;Characteristics;Clinical Chemistry Tests;clinical decision-making;Clinical Trials;cohort;computer science;Computerized Medical Record;Cross-Sectional Studies;daily functioning;Data;Data Collection;data de-identification;data integration;data mining;data repository;data resource;data sharing;Data Sources;Databases;demographics;design;Development;Dose;Ecological momentary assessment;Education;Evaluation;experience;Federal Government;Funding;General Population;Government Agencies;Health;Health system;Hemp;Hepatotoxicity;Industry;Injury;Interdisciplinary Study;interest;International;Internet;Knowledge;Label;Legal;Legal Medicine;Local Government;marijuana use;marijuana user;Measures;Medical Marijuana;Medicine;method development;Methods;Modeling;National Institute of Drug Abuse;Natural Language Processing;novel;Observational Study;Online Systems;Outcome;Paper;patient registry;patient subsets;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;poison control;Poison Control Centers;Poisoning;Policies;Policy Maker;Process;programs;prospective;Provider;Public Health;Publishing;Quality Control;Random Allocation;recruit;Registries;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Route;Scientist;Source;Summary Reports;Surveys;symptom management;Test Result;Testing;Therapeutic;Therapeutic Uses;tool;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Development of a Longitudinal Observational Research Registry for the Study of Medicinal Cannabis Use and Health


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: WASHINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative Homeostatic mechanisms are vital for the stability and normal function of neural circuits, but our understanding of the underlying molecular mechanisms, especially how they are triggered and recruited by physiologically relevant sensory stimulations, remains incomplete. In this proposal, we will implement innovative in vivo labeling and live imaging techniques to investigate the functional role of a recently-discovered neuronal membrane- associated proteasome (NMP) in visually driven plasticity paradigms. Understanding how NMP functions in the brain will shed light on a novel proteostasis-based fast homeostatic mechanism and may reveal new avenues for our understanding of the etiology of many neurodevleopmental and neurodegenerative disorders, where dysfunction of proteostasis has been implicated.

PI_NAMEs: HE, HAIYAN  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Amino Acids;Animal Behavior;avoidance behavior;Behavior;Behavioral;behavioral plasticity;Biochemical;Brain;cell type;Cells;cognitive function;Data;Development;Disease;Equilibrium;Etiology;experience;experimental study;Feedback;Functional Imaging;functional plasticity;Future;Health;Hippocampus;Homeostasis;Human;Hypothetical Protein;Image;imaging genetics;Imaging Techniques;improved;in vivo;innovation;Investigation;Label;Learning;Link;Maps;Mediating;Membrane;Memory;Methods;Microscopy;Molecular;Molecular Genetics;multicatalytic endopeptidase complex;Nature;neural circuit;Neurodegenerative Disorders;Neurons;Neurophysiology - biologic function;novel;Pathway interactions;Pattern;Physiological;Play;prevent;Process;Protein Biosynthesis;protein degradation;Proteins;Proteome;proteostasis;proteostasis loss;recruit;Regimen;Regulation;response;Role;Sensory;spatiotemporal;structural imaging;superior colliculus Corpora quadrigemina;Synapses;Synaptic plasticity;System;Tadpoles;Tectum Mesencephali;temporal measurement;Testing;Time;tool;Visual;visual motor;Visual System;Xenopus laevis

PROJECT_TITLE: Nascent protein degradation-based fast homeostatic mechanism mediated by neuronal membrane proteasomes

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ORG_CITY: TUCSON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE Children with wheezing and allergic inflammation have dysregulated responses to respiratory viral infection and develop difficulties in breathing. Here we will employ cutting-edge molecular profiling technologies and computational systems biology analyses to unlock the molecular pathways that determine dysregulated antiviral immunity leading to abnormal lung function. If successful, these studies will lead to the identification of novel pathways that represent logical targets for the treatment or prevention of asthma and related traits.

PI_NAMEs: BOSCO, ANTHONY  (contact)

PROJECT_TERMS: 2 year old;Accident and Emergency department;Acute;Adolescence;Affect;Affinity;Age;Airway Disease;airway epithelium;airway inflammation;airway obstruction;Allergens;Allergic inflammation;American;Animal Model;Animals;Anti-viral Response;antiviral immunity;Asthma;asthma exacerbation;asthma prevention;asthmatic;atopy;Back;Biological;Birth;Blood;Bone Marrow;Breathing;Bronchiolitis;burden of illness;Cells;Child;Childhood Asthma;Chronic;Chronic Disease;cohort;Data;Dendritic Cells;design;Development;Early Mobilizations;early onset;Eosinophilia;Epithelial Cells;Equilibrium;Exploratory/Developmental Grant;Family;gene network;Growth;Growth Factor;high risk;Hospitals;Human;Hypersensitivity;IgE Receptors;Immune;Immune response;Immunologic Factors;Immunologics;Infant;Infection;Inflammation;inpatient service;intercellular communication;interferon regulatory factor-7;Interferon Type I;Interferons;knock-down;Life;Longitudinal Studies;Lung;Mediating;Modeling;Molecular;molecular phenotype;Molecular Profiling;monocyte;Nasal Lavage Fluid;nasal swab;Natural Immunity;neutrophil;novel;novel strategies;Pathologic;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Population;Predisposing Factor;Predisposition;prevent;prospective;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Rat Strains;Rattus;Recording of previous events;recruit;Recurrence;Research;Resolution;respiratory;response;Rhinovirus;Risk;Sampling;Schools;Signal Transduction;Small Interfering RNA;Sputum;Structure;Systems Biology;T-Cell Activation;T-Lymphocyte;Technology;Testing;Time;Tissues;trait;transcriptomics;Translating;United States;Up-Regulation;Variant;Viral;Viral Respiratory Tract Infection;Virus;Visit;Wheezing

PROJECT_TITLE: Systemic and intercellular gene networks underlying RV-induced airways disease

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Genetics;Immunotherapy;Rare Diseases;Wound Healing and Care

ORG_CITY: CHARLOTTE

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

PHR: NARRATIVE Pemphigus is an autoimmune blistering skin disease that occurs sporadically across the globe but is triggered by environmental antigens that could be derived from an insect saliva protein or a virus in the endemic areas. Although the etiology of this unique disease remains unknown, it has been demonstrated that the variation in natural killer (NK) cell receptors and their ligands is strongly associated with the risk of developing pemphigus. Here we propose a comprehensive mapping of functional sequence and structural variation in the genomic regions encoding NK cell receptors, followed by a robust functional validation, to further our understanding of the control of NK cell cytotoxicity and function and its implications in disease.

PI_NAMEs: AUGUSTO, DANILLO G (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 19q13;Address;Adult;advanced disease;Affect;Alleles;Antigenic Variation;Antigens;Area;Autoimmune;Autoimmune Diseases;bioinformatics pipeline;Biological Assay;Biological Process;Bulla;Cell-Mediated Cytolysis;Cellular biology;Code;cohort;Complex;Comprehension;Copy Number Polymorphism;Coupled;Custom;cytotoxicity;Data Analyses;design;differential expression;Disease;Etiology;experience;Family;Foundations;Gene Cluster;Gene Expression;Gene Expression Regulation;Genes;genetic association;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome wide association study;Genomic Segment;genomic variation;Goals;Histocompatibility Antigens Class I;HLA Antigens;Immunoglobulins;Immunotherapy;Individual;innovation;Insecta;insight;Intercistronic Region;Killer Cells;Lesion;Leukocytes;Life;Ligands;Linkage Disequilibrium;Major Histocompatibility Complex;Maps;Mediating;Medical;Methods;Molecular Biology;Natural Killer Cells;Nature;next generation;next generation sequencing;novel;Outcome;Patients;Pemphigus;Pemphigus Vulgaris;Phase;Phenotype;Predisposition;Prevalence;Proteins;receptor;Receptor Cell;receptor expression;Regulation;Reporting;Research;Resolution;Risk;Role;Saliva;segregation;Severities;skin disorder;United States;Untranslated RNA;Validation;Variant;Virus

PROJECT_TITLE: The Variation of the NK Cell Receptome in Pemphigus

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Lung;Precision Medicine

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Chronic obstructive pulmonary disease (COPD) may act differently in different patients, although there are few well-defined types of COPD. We will study the genes that are turned on or off in patients with airway disease as part of their COPD. This will allow us to determine which COPD patients may get worse over time or may respond to steroid inhalers.

PI_NAMEs: HERSH, CRAIG P (contact)

PROGRAM_OFFICER_NAME: LU, QING

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Affect;Airway Disease;airway obstruction;Biological Markers;Blood;Blood specimen;chest computed tomography;Chronic Obstructive Pulmonary Disease;cigarette smoking;Clinical;clinical phenotype;Clinical Trials;Complement;COVID-19 pandemic;Data;Data Set;Diagnosis;Disease;disease classification;disease heterogeneity;disease natural history;Disease Outcome;disease phenotype;Disease Progression;disorder subtype;eosinophil;Eosinophilia;experience;Frequencies;Future;Gene Expression;Gene Expression Profile;Genes;genetic epidemiology;genetic signature;Goals;Guidelines;Image;Immune response;Impairment;Inflammation;Inhalation;Inhalators;insight;Interferon alpha;Interferon-beta;Interferons;Lung;Measures;Morbidity - disease rate;mortality;outcome prediction;Pathway interactions;Patients;Peripheral;Pharmacogenomics;Phase;phase 3 study;Phenotype;precision medicine;predicting response;predictive marker;predictive modeling;predictive signature;Pulmonary Emphysema;pulmonary function;pulmonary function decline;Pulmonary function tests;Recommendation;Research;Resected;Resolution;Respiratory Signs and Symptoms;response;Sampling;Scanning;small airways disease;Smoker;stability testing;Steroids;Structure of parenchyma of lung;Subgroup;targeted treatment;Testing;Time;trait;transcriptome sequencing;treatment response;trend;Viral;Virus Diseases;Visit;Visualization;Whole Blood

PROJECT_TITLE: Defining a gene expression signature of airway disease, COPD exacerbations, and response to treatment

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

PHR: Our research will produce critical resources for researchers and decision makers, including databases useful for characterizing the environmental and economic conditions associated with past filovirus (e.g., Ebola, Marburg) outbreaks and disease emergence risk maps. Africa is also a hotspot of many zoonotic diseases in addition to filoviruses (e.g., West Nile virus, brucellosis, malaria), and the databases and computational tools we develop will thus be applicable to many disease systems.

PI_NAMEs: STEPHENS, PATRICK  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acceleration;Affect;Africa;Agriculture;Animals;anthropogenesis;Biodiversity;Biohazardous Substance;Brucellosis;Cessation of life;Characteristics;Communicable Diseases;Communities;computerized tools;contagion;Data Set;Databases;Dimensions;Discipline;Disease;Disease Outbreaks;disease transmission;Ebola;Ebola virus;Economic Conditions;Economics;Epidemic;Filovirus;Goals;Gorilla gorilla;Guinea;Habitats;Health;Health system;Human;Human Activities;human subject;Individual;insight;Investments;iterative design;land conversion;large scale data;Laws;Malaria;Maps;Marburgvirus;mathematical model;Methods;Modeling;mortality;outbreak prediction;pathogen;pathogen spillover;Pattern;Phylogenetic Analysis;Physiological Processes;Population;Predisposition;Process;Research;Research Personnel;Resources;Risk;social;Socioeconomic Factors;socioeconomics;Source;spillover event;Statistical Models;System;Testing;Theoretical model;theories;Time;tool;transmission process;Variant;Vector-transmitted infectious disease;Virus;Weather;West Nile virus;Work;Zoonoses;zoonotic spillover

PROJECT_TITLE: Spillover of Ebola and other filoviruses at ecological boundaries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-U(55)R]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative - Overview Substance misuse remains the second most common mode of exposure to HIV among AIDS cases nationwide, representing 31% of total diagnoses. In addition, substance use is associated with a more severe course of HIV disease, as shown by the poor immune reconstitution and an increased rate of co-morbidities. The Case Western Reserve University (CWRU) Center for Excellence creates a collaborative environment that strongly supports Substance Use in HIV research at CWRU and for our colleagues in other NIDA-sponsored Centers nationwide.

PI_NAMEs: LEVINE, ALAN DAVID (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Affect;Award;Basic Science;Behavioral;behavioral health intervention;behavioral outcome;Behavioral Research;biobank;Bioinformatics;Biometry;Biomimetics;Brain;Cannabis;Capital;career;Caring;Cell model;Cells;Cities;Clinic;Clinical;clinical database;Clinical Investigator;Clinical Research;Cocaine misuse;cocaine use;cohort;collaborative environment;Communities;Community Outreach;comorbidity;Complex;Computational Biology;County;Databases;design;Development;Diagnosis;Discipline;Disease;Drug usage;Education;Equipment;experience;Exposure to;Faculty;Foundations;Functional disorder;Funding;gastrointestinal;Grant;Health;Hepatitis C co-infection;HIV;HIV/HCV;Hospitals;Immune;immune reconstitution;Immunologics;Immunosuppression;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Infrastructure;innovation;insight;interdisciplinary collaboration;International;Investigation;Leadership;lecturer;Link;lipidomics;marijuana use;Medical center;medical schools;Medicine;Memory impairment;Mental Health;Mentors;metabolomics;Methamphetamine;methamphetamine use;Methods;microbiome;Modeling;Molecular;Motivation;Mucous Membrane;Myelogenous;National Institute of Drug Abuse;neuroAIDS;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurological outcome;new technology;next generation;Opioid;opioid use;Outcome;Pathogenesis;Patient Recruitments;Patients;Persons;Physician Executives;Positioning Attribute;Prevention education;Prevention Research;Process;programs;Proteomics;Public Health;Reporting;Research;Research Personnel;Research Support;Resources;Risk;Rural;Schools;service intervention;Services;sexual risk behavior;Social Sciences;stem cells;Strategic Planning;substance misuse;substance use;Substance Use Disorder;suburb;Surveys;symposium;synergism;Systems Biology;Teacher Professional Development;Technology;three-dimensional modeling;Tissues;transcriptomics;Translational Research;Trauma;Underserved Population;United States Department of Veterans Affairs;Universities;University Hospitals;Victimization;Violence;violence prevention

PROJECT_TITLE: CWRU Center for Excellence on the Impact of Substance Use on HIV


NIH_SPENDING_CATS: Drug Abuse (NIDA only);HIV/AIDS;Neurosciences;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative – Administrative Core A Substance use remains the second most common mode of exposure to HIV among infected individuals nationwide, representing 31% of total diagnoses. In addition, substance use is associated with a more severe course of HIV disease as shown by poor immune reconstitution and increased rate of co-morbidities. This core provides administrative support to the CWRU Center for Excellence.

PROJECT_TERMS: Administrative Personnel;Advertising;Advisory Committees;Agreement;Anti-Inflammatory Agents;Astrocytes;Automobile Driving;Award;Behavioral;Big Data;biobank;Biomimetics;Blood - brain barrier anatomy;Cannabis;Capital;Cardiovascular system;Cell model;Cells;Chronic;Cities;Clinical;Cocaine;Collaborations;Communication;Communities;Community Outreach;comorbidity;Computational Biology;Computer software;County;Data Collection;Databases;Diagnosis;Disease;Dopamine;Dose;Drug usage;Education;Education and Outreach;Equipment;equipment acquisition;Evaluation;Excision;Exercise;Exposure to;Faculty;Faculty Recruitment;Functional disorder;Funding;Genetic;glial activation;Gliosis;gray matter;Growth;Health;HIV;immune reconstitution;Immunosuppression;improved;Individual;induced pluripotent stem cell;Inflammation;innovation;Institution;International;Investments;Leadership;lipidomics;Mediating;medical schools;Medicine;member;Memory impairment;Mental Health;Mentors;Mentorship;metabolomics;Methamphetamine;microbiome;Microglia;Modification;Motivation;National Institute of Drug Abuse;neuroAIDS;Neurocognitive Deficit;neuroinflammation;novel;Opioid;organizational structure;outreach;outreach program;Oxidative Stress;Participant;Pathology;Persons;Policies;Positioning Attribute;Predisposition;Process;programs;Proteomics;Public Health;Publishing;Recommendation;recruit;Reproducibility;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Resources;responsible research conduct;Science;Scientist;Services;single cell analysis;Strategic Planning;substance use;Suggestion;Surveys;System;Systems Biology;technological innovation;Technology;Training;transcriptomics;United States National Institutes of Health;viral rebound;Virus;Virus Latency;Virus Replication;vulnerable community;web site

PROJECT_TITLE: Administrative Core A


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;Nutrition;Women's Health Research

PHR: PROJECT NARRATIVE A better understanding of how metabolite sensing informs epigenetic responses has promise to uncover novel therapeutic targets for a broad spectrum of human malignancies because cancers depend on metabolic processes to fuel cell division and support malignant gene expression programs. This research proposal seeks to understand contributions of acetyl-co-A and short-chain fatty acids to breast cancer biology and characterize chemical inhibitors and activators of these pathways. In particular, focus on the histone acetyltransferase 1 enzyme complex will serve as a platform to better understand how cancer cells import acyl groups for nuclear epigenetic reactions that drive malignant processes.

PI_NAMEs: GRUBER, JOSHUA JAMES (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Acetates;Acetyl Coenzyme A;Acetyltransferase;acyl group;adverse outcome;Affect;Amino Acids;Anatomy;anti-cancer;Antineoplastic Agents;Award;Basic Science;Binding;Biochemical;Biological Assay;Biology;Breast Epithelial Cells;California;Cancer Biology;cancer cell;Cancer Cell Growth;cancer therapy;career;career development;Cell Culture Techniques;Cell Cycle;Cell division;Cell Line;Cell Nucleus;Cell Proliferation;Cells;Chemicals;Chromatin;chromatin modification;Clinical Oncology;cofactor;combat;Complement;Coupled;Critical Pathways;Data;Dependence;detection of nutrient;Development;Diagnosis;Diet;Dietary Fiber;Disease;Drug Targeting;Ensure;Enteral;Enzymes;Epigenetic Process;epigenetic regulation;expectation;experience;Experimental Models;Fiber;Foundations;Funding;Gastrointestinal tract structure;Gene Expression;Glucose;glucose metabolism;glucose sensor;Goals;Growth;Hand;HAT1 gene;Health;high-fat/low-fiber diet;histone acetyltransferase;Histones;Human;Impairment;improved;inhibitor;instructor;Intake;Investigation;K-Series Research Career Programs;Knowledge;Laboratories;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mass Spectrum Analysis;Medical;Medicine;Mentors;Metabolic;Metabolism;Modification;Molecular;mortality risk;mouse model;Multienzyme Complexes;Mutation;Neoplasms;new therapeutic target;novel;novel strategies;novel therapeutics;Nuclear;Nuclear Import;Nutrient;Nutrient availability;nutrient metabolism;Outcome;Oxygen;Pathway interactions;Patients;Pharmaceutical Chemistry;Physicians;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;professor;programs;Proliferating;Property;Propionates;Proteomics;Reaction;Renal Carcinoma;Repression;Research;Research Personnel;Research Proposals;response;Role;San Francisco;Scientist;sensor;Series;Signal Transduction;Site;small molecule;success;Systems Biology;Testing;Tissues;Training;tumor;tumor growth;tumor metabolism;tumorigenesis;Universities;Volatile Fatty Acids;Work

PROJECT_TITLE: Metabolite sensing through the HAT1 acetyltransferase as an anti-cancer target

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Harm Reduction for Substance Misuse;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: This is a competitive renewal that builds on a previous stakeholder-engaged cluster-randomized controlled trial across 28 college campuses and that focuses on undergraduate college students at elevated risk for sexual violence and hazardous drinking (i.e., students with prior history of sexual violence, students who are sexual or gender minority, and students with disabilities). “Reducing Alcohol Involved Sexual violence in higher Education (RAISE)” is a longitudinal study that will test research-informed strategies to improve implementation of a prevention intervention in college health and counseling centers, integrate a safety decision aid (via computer or mobile device) to more directly target harm reduction among students particularly vulnerable to hazardous drinking and SV, and evaluate campus policies that increase accessibility and uptake of confidential services for students. This is the first study to situate a sexual violence prevention intervention in college health and counseling centers to address two significant public health concerns -- alcohol-involved sexual violence and hazardous drinking on college campuses.

PI_NAMEs: MILLER, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Age;alcohol involvement;alcohol risk reduction;Alcohols;Awareness;Behavior;binge drinking;care seeking;Caring;Cellular Phone;Clinic;Clinic Visits;clinical practice;Coercion;college;comparison control;Computers;Counseling;Data;Data Collection;Decision Aid;disability;disabled students;Education;Educational Intervention;effectiveness evaluation;efficacy testing;Emotional;experience;follow-up;Forcible intercourse;gender minority;Glass;handheld mobile device;Harm Reduction;hazardous drinking;Health;higher education;Impairment;implementation barriers;implementation strategy;improved;Individual;Intervention;intervention delivery;Learning;longitudinal analysis;Longitudinal Studies;men;Neurologic;Participant;partner violence;Pennsylvania;Policies;Prevalence;preventive intervention;Provider;psychoeducational intervention;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;Relative Risks;Reporting;reproductive coercion;Research;Risk;Safety;Sampling;Self Efficacy;Sensory;Services;Sexual and Gender Minorities;sexual minority;sexual risk reduction;sexual violence;Sexual violence prevention;Students;Testing;Training;Trauma;undergraduate student;university student;uptake;Victimization;violence victimization;West Virginia;Woman

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stimulant Use and Misuse;Substance Misuse

PHR: Project Narrative – Primary Cell and iPSC-derived Cellular Models Core B Understanding the latent state of HIV and how it is impacted by substance use, specifically cocaine, methamphetamine, and opioids, is a central goal of the CWRU Center for Excellence on the Impact of Substance Use on HIV. Core B will provide primary cell ex vivo models and highly sensitive nucleic acid-based techniques to detect inducible viral RNA in cells recovered from patients. These assays will yield essential information about the control of latency in the brain, gut, and immune system. The Core will provide tools to manipulate and analyze primary cells that would not otherwise be available to Substance Use researchers at our institutions or nationwide.

PI_NAMEs: KARN, JONATHAN  (contact)

PROJECT_TERMS: Adaptive Immune System;antiretroviral therapy;Behavior;Biological;Biological Assay;Biological Models;Biomimetics;Blood Cells;Brain;brain endothelial cell;Cannabis;CD4 Positive T Lymphocytes;Cell Line;Cell model;cell transformation;cell type;Cells;Cerebral endothelium;Cerebrum;Circulation;Clinical;Clinical Trials;Cocaine;Coculture Techniques;Collaborations;Colon;Color;Complex;CRISPR/Cas technology;digital;DNA;droplet sequencing;Drug Modulation;drug of abuse;Drug Targeting;Drug usage;Epithelial Cells;Genes;genome editing;Goals;Guide RNA;HIV;HIV Genome;HIV Infections;human model;Immune system;immunoregulation;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Inflammation;Innate Immune System;innovation;Institution;intestinal epithelium;Intestines;latent HIV reservoir;Measures;metabolomics;Methamphetamine;Methods;Microglia;Migration Assay;Modeling;Modification;Molecular;monolayer;Mucous Membrane;Nervous System Disorder;Neurodegenerative Disorders;Neurons;new technology;novel;Nucleic Acids;Opioid;Organ;Organoids;Pathogenesis;Patients;Peripheral;Persons;Pharmaceutical Preparations;phenotypic biomarker;Primary Cell Cultures;Proteomics;Research;Research Personnel;Research Support;response;Ribonucleoproteins;RNA;Sampling;Services;single-cell RNA sequencing;Small Intestines;spheroids;stem cell organoids;stem cell technology;Stimulus;Study models;substance use;Substance Use Disorder;System;T memory cell;T-Lymphocyte;Techniques;Technology;Tissue Sample;Tissues;tool;Training;transcriptomics;Vascular Endothelial Cell;Vascular Permeabilities;viral detection;viral DNA;Viral reservoir;viral RNA;Virus

PROJECT_TITLE: Research Support Core B: Primary Cell, Biomimetic, and iPSC-derived Cell Models


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Back Pain;Biomedical Imaging;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: In this exploratory project we seek to extend our investigations of the role of neuroinflammation in human chronic pain to painful trigeminal neuropathy. All participants will receive brain imaging with integrated PET/MRI, before steroid treatment. We will test whether 1) patients demonstrate abnormally elevated PET and MRS markers of neuroinflammation, and whether 2) these brain signals can predict response to steroids.

PI_NAMEs: CHENG, HSINLIN THOMAS;LOGGIA, MARCO LUCIANO (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Affect;Anterior;Anti-Inflammatory Agents;Area;Astrocytes;Behavioral;Brain;Brain imaging;Brain scan;Brain Stem;cell type;Central Nervous System;Chronic low back pain;chronic pain;chronic pain patient;chronic painful condition;cingulate cortex;Clinical;clinically significant;Contralateral;Data;Data Set;depressive symptoms;Development;Disease;Disease Management;Enrollment;Etiology;experience;Face;Facial Pain;Fibromyalgia;Generations;glial activation;HIV;Human;Image;imaging study;Imaging technology;improved;in vivo;Inflammatory;Intervention;Investigation;Ipsilateral;Knee Osteoarthritis;Knowledge;Low Back Pain;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maintenance;Measures;Medical;Methodology;Microglia;Migraine;Molecular;Multimodal Imaging;multimodality;myoinositol;neural;Neurodegenerative Disorders;Neuroglia;neuroinflammation;Neurologist;Neurons;Nociception;novel;Operative Surgical Procedures;Oral;overexpression;Pain;Pain Disorder;Pain management;pain-related disability;painful neuropathy;Participant;Pathway interactions;Patient imaging;Patient Schedules;Patients;Peripheral;Persistent pain;Positioning Attribute;Positron-Emission Tomography;pre-clinical;preclinical study;predicting response;Prediction of Response to Therapy;Prednisone;prevent;Proteins;Questionnaires;radioligand;recruit;Rest;Role;Scanning;Schedule;Sensory;Severities;Side;Signal Transduction;somatosensory;Somatosensory Cortex;Spatial Distribution;Specificity;Steroid therapy;Steroids;Structure of trigeminal ganglion;Symptoms;Testing;Thalamic structure;therapeutic target;tool;Translations;Trauma;Trigeminal Nerve Diseases;Trigeminal nerve structure;Trigeminal System;Virus Diseases;Visit;Work

PROJECT_TITLE: In-vivo Assessment of Neuroinflammation in Painful Trigeminal Neuropathy

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Infectious Diseases;Wound Healing and Care

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Our lab recently identified genetic material from phage (a virus that infects bacteria) that promoted bacterial skin infection during an outbreak of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). To understand why the phage promotes CA-MRSA disease, we will delete candidate gene(s) on the phage for testing in a mouse skin infection model to identify which gene(s) are responsible, and we will determine the effect of the phage on bacterial gene expression during infection. In addition to broadening scientific knowledge about the role of phages in bacterial infection, insights gained from the proposed study will provide novel targets for outbreak surveillance and antibiotic development.

PI_NAMEs: ULRICH, ROBERT JAMES (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Abscess;Address;Advisory Committees;Affect;alpha Toxin;Antibiotics;Automobile Driving;Award;Bacteria;Bacterial Genes;Bacterial Genome;Bacterial Infections;Bacteriophage Genetics;Bacteriophages;Candidate Disease Gene;career;Centers for Disease Control and Prevention (U.S.);Cessation of life;Child;clinical effect;clinically relevant;clinically significant;combat;Communities;comparison control;Complement;Complex;contagion;cytotoxicity;Development;Disease;Disease Outbreaks;Engineering;Epidemic;Evolution;fitness;Foundations;Gene Expression;Gene Expression Profile;Genes;Genetic Materials;Genetic Transcription;Genetic Variation;genome sequencing;Goals;Growth;Hospitalization;Hospitals;In Vitro;in vivo;Infection;Infectious Skin Diseases;insight;Knock-out;Knowledge;Laboratories;Leucocidin;Link;Lysogeny;Measures;Mediating;Medical Genetics;Mentors;methicillin resistant Staphylococcus aureus;Methyltransferase;Modeling;Molecular;mosaic;Mouse Strains;Mus;mutant;Mutation;neutrophil;new therapeutic target;New York;novel;novel therapeutics;pathogen;Pathogenesis;Pathway interactions;Phenotype;Phylogenetic Analysis;Physicians;Play;Production;Prophages;public health emergency;Regulation;Regulatory Pathway;Research;Research Training;Role;Scientist;Signal Transduction;skin abscess;Soft Tissue Infections;Staphylococcus aureus;Staphylococcus aureus infection;success;synergism;Testing;Toxin;Toxin Conjugates;Training;transcriptome sequencing;United States;Up-Regulation;Variant;Virulence;Virulence Factors;Virulent;Virus;whole genome;Work

PROJECT_TITLE: Mechanisms of Prophage-Mediated Virulence Driving Community-Acquired MRSA Contagion

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

PHR: PROJECT NARRATIVE Bacterial division and differentiation are carried out by intricate, molecular machines that are spatially and temporally regulated. Most of our knowledge regarding these processes is restricted to ‘model organisms’ whose genomes tend to encode highly complex structural and regulatory systems that are often absent in more genetically-reduced organisms. The work proposed here outlines a series of studies to address how more minimalist microbes carry out these basic, cellular processes, and assess the capabilities inherent to the molecular complexes conserved between ‘model’ and ‘non-model’ microbes.

PI_NAMEs: LIECHTI, GEORGE WARREN (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Anabolism;Area;Bacteria;Cell Differentiation process;Cell division;Cell Physiology;Cell Shape;Cell Size;Cell Wall;Cells;Cellular Stress;Chlamydia;Chlamydiaceae;Complex;Development;Elements;Environment;Exhibits;Five-Year Plans;Genome;Investigation;Knowledge;Life;member;Metabolic;Microbe;model organism;Modeling;Molecular;Molecular Machines;Organism;Osmosis;Peptidoglycan;Physiological Processes;Process;response;Role;Series;Stress;System;Work

PROJECT_TITLE: Cellular organization, division, and differentiation in an ancient, genetically reduced bacterium

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE We will determine whether single-dose azithromycin is effective in preventing cholera in children who are at extremely high risk of infection. We will also determine the effect of this intervention on the development of antibiotic resistant bacteria. The results will inform future strategies to prevent cholera in children, and improve our understanding of the impact of azithromycin on antibiotic resistance.

PI_NAMEs: HARRIS, JASON B (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: Address;Advisory Committees;Age;Antibiotic Prophylaxis;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antigen test;Antimicrobial Resistance;Area;Azithromycin;Bacteria;Bacterial Antibiotic Resistance;Bangladesh;Case Study;Cessation of life;Chemoprophylaxis;Child;Cholera;Cholera Vaccine;Clinical;clinical care;clinical practice;Cluster randomized trial;cooking;Data;Dehydration;Detection;Development;Diarrhea;Disease;Dose;Education;effectiveness measure;effectiveness testing;Eligibility Determination;Enrollment;Environment;Epidemic;Feces;Future;Goals;group intervention;gut bacteria;high risk;Hour;Household;Hygiene;improved;indexing;Infection;infection risk;Intervention;intervention effect;IV Fluid;Knowledge;liquid chromatography mass spectroscopy;Measures;member;Metagenomics;Molecular;Monitor;mortality;Only Child;Oral;Outcome;Participant;Patient Self-Report;Patients;placebo group;Placebos;post intervention;prevent;Prevention;Prevention strategy;prophylactic;Prophylactic treatment;prospective;Prospective Studies;Public Health Practice;Randomized;rapid diagnosis;Recommendation;Research Design;Research Priority;Risk Reduction;Sanitation;Severities;Site;standard of care;Symptoms;Testing;Time;transmission process;trial enrollment;Vaccines;Variant;Vibrio cholerae;Vibrio cholerae infection;Vibrio cholerae O1;Visit;Vomiting;Water;World Health Organization;Yemen

PROJECT_TITLE: Single dose azithromycin to prevent cholera in children

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-G(90)]