ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: NARRATIVE: Alzheimer's disease and related dementias globally of a significant pathogenic contributor to Alzheimer's disease, acts remain a leading cause of mortality and morbidity and neurovascular dysregulation has emerged as a critical factor that increases the risk developing cognitive impairment. The present application seeks to examine how on perivascular macrophages amyloid-beta, andleads to neurovascular dysfunction.The application will widen our knowledge basis for the cellular mechanisms of harmful neurovascular effects of amyloid-beta.

PI_NAMEs: PARK, LAIBAIK  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: abeta accumulation;abeta deposition;Activities of Daily Living;Address;Affect;aged;Alteplase;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid pathology;attenuation;Behavioral;beta amyloid pathology;Blood flow;blood flow measurement;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;Brain;brain dysfunction;Brain Pathology;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular system;Cerebrum;Chimera organism;Cognition;Cognitive;Cognitive deficits;cognitive function;Couples;Cre driver;Deposition;Disabling condition;Disease;Endothelium;Ensure;Enzymes;extracellular;Functional disorder;Funding;Gene Deletion;Gene Targeting;Genes;Genetic;Glutamates;Histopathology;Hyperemia;Impaired cognition;Impairment;In Vitro;in vivo;Individual;interdisciplinary approach;Knockout Mice;Knowledge;Lasers;Leptomeninges;Long-Term Effects;Macrophage;MAPT gene;Mediating;Methods;Microglia;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;NADPH Oxidase;Natural Immunity;neural;Neurofibrillary Tangles;Neurons;neuropathology;neurovascular;Nitric Oxide;novel;novel strategies;overexpression;Pathogenicity;Pathology;Pathway interactions;Penetration;Perfusion;Personal Satisfaction;pharmacologic;Phenotype;Plasminogen Activator Inhibitor 1;Plasminogen Inactivators;Process;Production;Reactive Oxygen Species;receptor;Regulation;response;Risk;Senile Plaques;sex;Sex Differences;Source;Structure;Swedish mutation;Synapses;Tamoxifen;targeted treatment;Techniques;Testing;Tg2576;Therapeutic Intervention;tool;Transgenic Mice;Up-Regulation;Vasodilator Agents

PROJECT_TITLE: tPA and Cerebrovascular Regulation in a Model of ß-amyloid Pathology

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: AT

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Services;Mental Health;Mental Illness;Pain Research;Post-Traumatic Stress Disorder (PTSD);Primary Health Care;Rural Health;Serious Mental Illness

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The current proposal is designed to position the candidate to be a leading independent investigator focused on the development and evaluation of systems-based approaches for effectively delivering complementary and integrative health (CIH) interventions (e.g., non-pharmacologic mind-body interventions such as mindfulness meditation) for common chronic conditions. The proposal focuses on chronic pain and co-occurring posttraumatic stress disorder (PTSD), a population of patients who often seek treatment in primary care, where effective CIH interventions may not be available due to limited resources or patient access (e.g., community care in rural settings). The current proposal utilizes user-centered design strategies to incorporate CIH interventions into proven stepped care approaches designed for primary care settings, and then pragmatically tests the novel approach.

PI_NAMEs: REED, DAVID E (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Adherence;Administrator;Affect;Alaska;Award;Back;career;career development;Caring;Characteristics;Chronic;chronic pain;chronic pain management;chronic pain patient;Chronic Post Traumatic Stress Disorder;Clinic;Clinical;Clinical Trials Design;Collaborations;Community Healthcare;Complementary Health;Complex;Data;Data Analyses;Dedications;design;Development;Diagnostic Factor;dissemination science;early phase trial;Ensure;Evaluation;evidence base;experience;Faculty;Feedback;Focus Groups;Foundations;Funding;Goals;Grant;Health system;Healthcare Systems;Human Subject Research;Idaho;implementation science;improved;Individual;Institution;Integrative Medicine;interest;Intervention;Interview;Learning;learning strategy;Measurement;Measures;member;Mental Health;Mentors;Mentorship;Mind-Body Intervention;mind/body;mindfulness meditation;Modeling;Montana;National Center for Complementary and Integrative Health;Nonpharmacologic Therapy;novel;novel strategies;opioid epidemic;Pain;Pain interference;Pain management;pain outcome;Participant;Pathway interactions;patient population;patient response;Patients;Personal Satisfaction;Phase;physical conditioning;pilot test;pilot trial;Positioning Attribute;Post-Traumatic Stress Disorders;Pragmatic clinical trial;pragmatic trial;Primary Care;primary care clinic;primary care setting;primary care team;Process;professor;programs;prototype;Provider;Randomized;randomized effectiveness trial;Readiness;Recording of previous events;Research;Research Personnel;Resources;rumination;Rural;rural setting;satisfaction;Site;Structure;Symptoms;System;Technology;Testing;Training;treatment as usual;treatment planning;Treatment Protocols;treatment response;treatment strategy;trial design;Use Effectiveness;user centered design;Visualization;Washington;Writing;Wyoming

PROJECT_TITLE: Complementary and Integrative Health Stepped Care for Co-occurring Chronic Pain and PTSD


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Hepatitis;Hepatitis - C;Immunization;Infectious Diseases;Liver Disease;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative A vaccine against hepatitis C virus (HCV) is needed, but we have been unable to design a vaccine that stimulates protective, broadly neutralizing antibodies against HCV. By molecularly and structurally characterizing interactions between HCV envelope proteins and monoclonal antibodies capable of blocking diverse HCV variants, we will facilitate rational design of a vaccine against HCV. These studies could also have broad application for design of vaccines against other highly variable human viruses.

PI_NAMEs: BAILEY, JUSTIN RICHARD (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affinity;Animal Model;Anti-viral Agents;Antibodies;Antibody Binding Sites;Antibody Response;Award;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;B-Lymphocytes;Binding;Cell Separation;Chronic;chronic infection;Complex;Country;Cryoelectron Microscopy;design;Development;Disease;Disease Outcome;effective therapy;env Gene Products;Epitopes;Genetic;Germ Lines;Glycoproteins;Goals;Hepatitis C;Hepatitis C Antibodies;Hepatitis C Incidence;Hepatitis C Vaccine;Hepatitis C virus;HIV;Human;Immune response;Immunological Models;improved;In Vitro;Individual;Infection;Length;Measures;Methods;Molecular;Monoclonal Antibodies;neutralizing antibody;Persons;Phase;Plasma;Process;Proteins;Public Health;rational design;Resolution;Somatic Mutation;Sorting;Structure;Surveys;T cell response;T-Lymphocyte;Techniques;Time;Vaccine Antigen;vaccine candidate;Vaccine Design;vaccine development;Vaccines;Variant;Viral;Viremia;Virus;Virus Diseases;virus envelope;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular and structural characterization of broadly neutralizing anti-HCV antibodies

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Prevention;Vaccine Related

ORG_CITY: CHAPEL HILL

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE There is little known about natural immunity to sapovirus. The main goal of this project is to characterize mucosal humoral immunity to sapovirus in early childhood using longitudinal samples collected from a birth cohort in León, Nicaragua. Our unique interdisciplinary collaboration affords us the ability to link biological samples and data from children in a high-burden setting to innovative analytic approaches to better understand sapovirus immunology and inform the development of sapovirus vaccines.

PI_NAMEs: BECKER-DREPS, SYLVIA IRENE (contact);DIEHL, SEAN A.

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: Acute;Address;Age;Age Months;analytical tool;Antibodies;Antibody Repertoire;Antigens;B cell repertoire;B-Lymphocytes;Binding;Biological;Birth;Body Fluids;burden of illness;Calicivirus;Cell Separation;Cells;Child;Childhood;Clone Cells;cognitive development;cohort;Cohort Studies;Collaborations;Collecting Cell;Data;Development;Diarrhea;Disease;early childhood;Enteral;enteric pathogen;Epidemiology;epidemiology study;experience;Family;Feces;Funding;Future;Gastroenteritis;Genotype;Goals;Homing;Human;Humoral Immunities;Immune;Immune response;Immunity;Immunoglobulin A;Immunoglobulin G;Immunoglobulins;Immunologic Memory;Immunologics;Immunology;improved;Incidence;Infection;innovation;interdisciplinary collaboration;Intestines;Kinetics;Laboratories;Learning;Life;Link;Longevity;Maps;Measurement;Measures;Memory B-Lymphocyte;Methods;Modeling;Monoclonal Antibodies;Mucosal Immunity;Mucous Membrane;multidisciplinary;Natural Immunity;neutralizing antibody;Nicaragua;Nicaraguan;Norovirus;novel strategies;Pattern;Peripheral Blood Mononuclear Cell;phase III trial;Phenotype;Play;Population;Prevalence;preventive intervention;Production;Publishing;receptor;Reporting;Resources;response;Role;Rotavirus;Saliva;saliva sample;Sampling;Sapovirus;Secretory Immunoglobulin A;Serum;Site;Small intestine mucous membrane;Stable Populations;stool sample;Techniques;Testing;Time;United States National Institutes of Health;Vaccine Design;vaccine development;vaccine formulation;Vaccines;Viral Load result;Virus;Virus-like particle

PROJECT_TITLE: Mucosal immunity to sapovirus in early childhood

STUDY_SECTION: EDIT

STUDY_SECTION_NAME: Etiology, Diagnostic, Intervention and Treatment of Infectious Diseases Study Section[EDIT]


NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Rare Diseases

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Charcot-Marie-Tooth disease (CMT) includes many forms of inherited peripheral neuropathy that collectively affect ~1:2500 people, and since there are no approved treatments, CMT represents a large unmet clinical need. We recently found that a cellular stress response contributes to the severity of some forms of CMT, providing a potential therapeutic target. This proposed research will explore how the cellular stress response exacerbates neuropathy and may provide additional, more focused, options for treatment.

PI_NAMEs: BURGESS, ROBERT W. (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Affect;Amino Acids;Amino Acyl-tRNA Synthetases;Axon;axonal degeneration;Behavioral;Binding;biological adaptation to stress;Body Weight;Breeding;cell type;Cells;Cellular Stress;Charcot-Marie-Tooth Disease;Charge;Clinical;clinically relevant;Codon Nucleotides;Collection;conditional knockout;Data;Defect;Disease;Dominant Genes;dominant genetic mutation;Double-Stranded RNA;Enzymes;Eukaryotic Initiation Factor-2;Eukaryotic Initiation Factors;experimental study;Frequencies;GARS gene;Gene Deletion;Gene Expression;Gene Expression Profiling;Gene Family;Genes;Genetic;Glycine;Glycine-Specific tRNA;Goals;Housekeeping;Housekeeping Gene;Human;improved;in vivo;Incidence;Inherited;Mediating;misfolded protein;Motor;Motor Neurons;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Neural Conduction;Neurons;Neuropathy;neurophysiology;neuroprotection;novel;Outcome;overexpression;Paper;Peripheral;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;primary outcome;Process;Proteins;reduced muscle mass;Reproducibility;Research;Ribosomes;Role;sensor;sensory neuropathy;Severities;Severity of illness;Spinal;Spinal Cord;stressor;Supportive care;Therapeutic Intervention;therapeutic target;transcription factor;Transfer RNA;Transfer RNA Aminoacylation;Transgenes;Transgenic Organisms;Translating;translation assay;Translations;Virus Diseases

PROJECT_TITLE: Dissecting the Integrated Stress Response in tRNA Synthetase-Associated Neuropathies

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Chronic Pain;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Pathological pain is a major international public health priority and there is an acute need for effective and non- addictive treatments; progress toward this goal depends critically on a comprehensive understanding of its underlying molecular mechanisms. The focus of my proposal is to identify key epigenetic mechanisms that control transcript identity in nociceptors of dorsal root ganglia; nociceptors are neurons that undergo abnormal changes in activity following nerve damage and these changes are associated with the pathophysiology of neuropathic pain. The long-term goal is to inform development of new therapies to mitigate neuropathic pain.

PI_NAMEs: LOPEZ SOTO, EDUARDO JAVIER (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Academia;Acute;addiction;Alternative Splicing;Analgesics;Animal Model;Area;Award;Behavioral;Binding;Bioinformatics;bisulfite sequencing;Calcium;Calcium Channel;career;career development;Cells;Cellular biology;ChIP-seq;chronic pain;Complement;Computational Biology;Computer Analysis;CRISPR/Cas technology;Data;Data Set;Development;Disease;DNA Binding;DNA Methylation;DNA Modification Process;DNA-Binding Proteins;Effectiveness;Electrophysiology (science);Environment;epigenetic marker;Epigenetic Process;Event;Exhibits;Exons;experimental study;Family;Fellowship;Functional disorder;Funding;Gene Abnormality;Gene Expression;Gene Family;Genes;genome-wide;genome-wide analysis;Genomic DNA;Goals;Grant;Growth and Development function;human disease;improved;In Vitro;in vivo;inhibitor;injured;International;Kinetics;large datasets;Maps;Mentors;Methods;Modification;Molecular;Molecular Biology;Morphine;mouse model;mRNA Precursor;Mus;nerve damage;nerve injury;Nervous System Disorder;Neurons;neurotransmitter release;Nociceptors;novel therapeutics;Opioid Receptor;Pain;painful neuropathy;patch clamp;Pathologic;Pathology;Pattern;Peripheral nerve injury;Phase;Phenotype;Property;Protein Isoforms;public health priorities;recruit;Regulation;Research;Research Personnel;Resolution;RNA Polymerase II;RNA Splicing;RNA-Binding Proteins;Scientist;skills;spared nerve;Spinal cord posterior horn;Spinal Ganglia;Spliced Genes;success;Techniques;Therapeutic;therapeutic effectiveness;therapeutic target;tool;Training;Transcript;transcriptome;transcriptome sequencing;Universities;Viral;voltage;whole genome

PROJECT_TITLE: Abnormal Gene Splicing in Neuropathic Pain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: ATHENS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Narrative Bordetella pertussis resides within airways attached, often in large numbers, to cilia of columnar epithelia and awash in the mucus and sol that overly respiratory epithelia. Attempt to study its attachment and interactions with host cells have been in the context of cells and bacteria all submerged in a very rich growth media, and often result in the death of the host cells. Here we utilize a realistic air-liquid interface in vitro system in which bacteria must cross mucus and sol layers to reach fully differentiated complex epithelial tissue, in which they demonstrate behaviors substantially different from the submerged culture system.

PI_NAMEs: HARVILL, ERIC T (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adherence;Affect;Air;airway epithelium;Anti-Inflammatory Agents;Apical;Appearance;Architecture;Bacteria;Bacterial Adhesins;Bacterial Attachment Site;Behavior;Binding;Biological Assay;Biology;Bordetella;Bordetella pertussis;cell behavior;Cell Culture System;Cell Culture Techniques;cell injury;Cell Line;cell type;Cells;Cessation of life;Cilia;Clinical;Clinical Data;Colloids;Columnar Epithelium;Complex;Culture Media;Cultured Cells;Cytopathology;cytotoxic;cytotoxicity;Data;Disease;emerging pathogen;Epithelial Cells;Epithelium;experience;experimental study;feeding;Fibroblasts;Genetic;Goblet Cells;Growth;Health;Human;Immunity;In Vitro;in vivo;Incidence;Individual;Infection;Infiltration;Inflammatory;Inflammatory Response;Interruption;Liquid substance;Lung;Macrophage;Mammalian Cell;Measurable;Measures;Mediating;Microbiology;monolayer;Mucous body substance;Mucous Membrane;Mus;novel vaccines;Nutrient;pathogen;Pathogenesis;pathogenic bacteria;Penetration;Pertussis;Pertussis Toxin;Pertussis Vaccine;Population Heterogeneity;Predisposition;Production;Respiratory System;Role;Side;Signal Transduction;Site;Structure;success;Surface;System;Targeted Research;Techniques;Tight Junctions;Time;Tissues;Trachea;transmission process;United States National Institutes of Health;unvaccinated;Vaccines;Virulence Factors;Viscosity

PROJECT_TITLE: An air-liquid interface system to study Bordetella pertussis interactions with respiratory epithelia


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: ANN ARBOR

ORG_DEPT: UROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative This national study will comprehensively assess the effects of expansion of the advanced practice provider workforce into surgical groups. Findings from this study will shed light on how integration of these providers into surgical practice can be utilized to improve surgical access and outcomes in the elderly, and in certain vulnerable populations in particular.

PI_NAMEs: ELLIMOOTTIL, CHANDY SKARIA (contact);HOLLENBECK, BRENT K.;SHAHINIAN, VAHAKN B

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Effects of integration of advanced practice providers into surgical group practice

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The early phase of the HIV lifecycle is a fertile area for antiretroviral drug development as demonstrated by the reverse transcriptase and integrase inhibitors that have changed the lives of millions. We have assembled a team of established and early-stage HIV researchers with multidisciplinary expertise to address critical gaps in our understanding of how early steps in the HIV lifecycle dictate productive infection. This increased understanding should facilitate the identification of new targets and antiretrovirals to improve the lives of people living with HIV/AIDS around the world.

PI_NAMEs: BIENIASZ, PAUL D.;HOPE, THOMAS  (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Address;Anti-Retroviral Agents;Area;Behavior;Biochemical;Biological;Biological Assay;Biological Phenomena;Biological Process;Biology;Cell Compartmentation;Cell Culture Techniques;cell immortalization;Cell Line;Cell model;Cell Nucleus;cell type;Cells;Cellular biology;Complex;Conflict (Psychology);Consensus;CRISPR/Cas technology;Cryoelectron Microscopy;Cytoplasm;Data;Development;Disparity;DNA;drug development;Electron Microscopy;Equipment;Event;experience;Fluorescence Microscopy;Gene Modified;Genes;Genetic;Genome engineering;Goals;HIV;HIV Genome;HIV therapy;HIV-1;HIV/AIDS;Human;Image;imaging approach;improved;in vivo;Individual;Infection;innovation;insight;Integrase;Integrase Inhibitors;Integration Host Factors;Kinetics;Knowledge;Label;Life Cycle Stages;Link;live cell imaging;Location;Maps;Measurement;Measures;medical specialties;member;Methods;Microscopy;Modeling;Molecular;molecular imaging;multidisciplinary;Mutation;Nature;novel;Nuclear;Nuclear Pore;Nuclear Pore Complex;Paint;particle;Pathway interactions;permissiveness;Persons;Phase;Phenotype;Play;population based;Positioning Attribute;pre-exposure prophylaxis;prevent;Prevention;Process;Productivity;Provirus Integration;Proviruses;Research;Research Personnel;Reverse Transcription;RNA-Directed DNA Polymerase;Role;Route;Series;small molecule inhibitor;Specialist;Structure;Systems Biology;Techniques;Technology;Therapeutic;therapeutic target;tool;trafficking;Translating;treatment optimization;Treatment Protocols;ultra high resolution;uptake;Viral;Virion;Virus;Visualization

PROJECT_TITLE: Functionally Defining HIV-Host Interactions During the Early HIV-1 Lifecycle


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

PHR: Project Narrative The proposed study will provide novel insights into the location-specific functions interferon induced genes play in coordinating innate antiviral responses during viral infections.

PI_NAMEs: SAVAN, RAM  (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 2019-nCoV;Affect;AGFG1 gene;Alpha Virus;Anti-viral Agents;Anti-viral Response;antiviral immunity;Biochemical;Biological Markers;C-terminal;Cells;Chemicals;Cholesterol;Clinic;Coronavirus;Data;Development;DNA;Drug Targeting;Enterovirus;Enzymes;Family;Family Picornaviridae;Flavivirus;Genes;Grant;Host Defense;Hydrophobicity;Immune;Immune response;Immune system;Immunity;Infection;inhibitor;innovation;insight;Interferons;Life Cycle Stages;Ligase;Lipids;Location;Malignant Neoplasms;Membrane;Modification;monocyte;Natural Immunity;new therapeutic target;novel;oligoadenylate;pathogen;pathogenic virus;Pathway interactions;Phase;Play;Population;Post-Translational Protein Processing;Predisposition;prenylation;programs;Protein Isoprenylation;Proteins;Proteome;response;RNA;RNA Viruses;Role;Signal Transduction;Silicon Dioxide;Site;Specificity;Tail;Testing;Therapeutic Effect;Viral;Viral Pathogenesis;Viral Physiology;Viral Proteins;Virus;Virus Diseases;Virus Replication;West Nile virus;Work;Zika Virus;Zinc Fingers

PROJECT_TITLE: Prenylation in antiviral immunity


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Gene Therapy;Genetics;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE MS is a neuro-inflammatory autoimmune disease in which T cell driven inflammation leads to demyelination and damage of axons. The overall goal for is proposal is to develop a clinically relevant Adeno-associated virus (AAV) immunotherapy that will restore tolerance in an autoimmune setting such as Multiple Sclerosis (MS). We will show that our protocol will induce and expand antigen (Ag)-specific regulatory T-cells (Tregs) in vivo and independent of MHC or epitope restrictions.

PI_NAMEs: HOFFMAN, BRAD E (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: adeno-associated viral vector;Animal Model;Antigen Presentation;Antigen Targeting;antigen-specific T cells;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;autoreactivity;axon injury;Biological Markers;Breeding;Bystander Suppression;cDNA Library;Cell Communication;Chronic;Clinical;clinically relevant;CNS autoimmune disease;Code;Complex;Demyelinations;Dependovirus;design;Deterioration;Development;Disease;Disease Progression;Dose;Effectiveness;effector T cell;engineered T cells;Engineering;Epitope spreading;Epitopes;Experimental Autoimmune Encephalomyelitis;Genes;Genomics;Goals;Hepatic;Hybrids;Immune;Immune Tolerance;Immunodominant Epitopes;immunogenic;immunoregulation;Immunotherapy;in vivo;Inflammation;Inflammatory Response;insight;Left;Liquid substance;Mainstreaming;Mediating;Modeling;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;Myelin Proteins;neoantigens;neuroinflammation;novel;Paralysed;Pathogenesis;Pathogenicity;Patients;Population;prevent;Proteins;Protocols documentation;Recovery;Regulatory T-Lymphocyte;Reporting;restoration;Role;Side;single-cell RNA sequencing;Specificity;System;T-cell receptor repertoire;T-Lymphocyte;Testing;Therapeutic Agents;Therapeutic Effect;Time;transcriptome;transgene expression;Transgenes;V(D)J Recombination;vector;Viral Load result

PROJECT_TITLE: Restoring Immune Tolerance in a Model of Multiple Sclerosis

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

ORG_CITY: CHARLOTTE

ORG_NAME: CAROLINAS MEDICAL CENTER

PHR: Project Narrative Current prevention protocols for people at risk for infective endocarditis (IE) focus on antibiotic prophylaxis prior to invasive dental office procedures for only 10% of people at risk for this life- threatening disease. Although a high percentage of cases of IE are caused by bacterial species from the mouth, there are only informal guidelines on prevention for the remaining 90% of people at risk. This study will determine if improved oral hygiene and reduction of gingival inflammation decrease the incidence and duration of bacteremia of IE-causing oral species, which would refocus longstanding guidelines on prevention for all people at risk for IE.

PI_NAMEs: LOCKHART, PETER B (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Address;Antibiotic Prophylaxis;Bacteremia;Blood;Blood Circulation;Calculi;Cardiac;clinical practice;Clinical Trials;Data;dental biofilm;Dental Calculus;Dental Hygiene;Dental Offices;Dental Plaque;Development;Disease;Educational Intervention;Enrollment;Frequencies;Funding;Funding Agency;Gingiva;Goals;group intervention;Guidelines;Health;healthcare community;Heart Valves;Hospitalization;improved;Incidence;Infective endocarditis;Inflammation;Instruction;Intervention;Life;Measures;Morbidity - disease rate;mortality;Mouth Diseases;National Institute of Dental and Craniofacial Research;novel;Oral;oral care;Oral cavity;Participant;Pathway interactions;Patients;Persons;Populations at Risk;Practice Guidelines;Prevention;Prevention Guidelines;Prevention Protocols;Preventive care;Preventive measure;Procedures;Prospective Studies;Randomized;randomized trial;Reporting;Risk;Risk Factors;Risk Marker;Risk Reduction;Solid;Step Tests;Surrogate Markers;Testing;Time;Toothbrushing;treatment group;universal prevention;Work

PROJECT_TITLE: Randomized Trial of non-Surgical Therapy and Oral Hygiene Instruction to Reduce Risk of Infective Endocarditis


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE Blood pressure (BP) variability has emerged as a potential novel risk factor for dementia, yet its clinical translation has been hampered by the lack of standards for assessing BP variability and our poor understanding of the underlying mechanisms. This project will provide novel and comprehensive epidemiological evidence on and new mechanistic insights into the relationship between BP variability and dementia. We expect these findings will identify BP variability as a novel marker for dementia prediction and prevention, and this may ultimately guide a neuroprotective strategy where BP management focuses on BP variability as well as BP level in clinical practice.

PI_NAMEs: MA, YUAN  (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Address;Aging;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid beta-Protein;Atherosclerosis Risk in Communities;Autopsy;beta amyloid pathology;Biological;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure variability;Blood Vessels;brain magnetic resonance imaging;cardiovascular disorder risk;career;cerebral microbleeds;Cerebral small vessel disease;Cerebrovascular Disorders;Cities;Clinical;clinical practice;clinical translation;cohort;Cohort Studies;Coronary heart disease;Data;Data Sources;Dementia;dementia risk;Deposition;Disease;economic cost;epidemiologic data;Epidemiologic Methods;Epidemiology;epidemiology study;Etiology;Europe;experience;Family;Framingham Heart Study;Future;Goals;Heterogeneity;Hypertension;Image;Individual;insight;Investigation;Kidney Diseases;Knowledge;Life Expectancy;Link;Longitudinal cohort;Measurement;Measures;Mediating;Mediation;Medical;Medicine;Memory;Methods;Modification;mortality;mortality risk;neuroimaging;neuropathology;neuroprotection;novel;novel marker;older adult;Participant;Pathologic;Pathology;Pathway interactions;Persons;Phase;Positioning Attribute;Positron-Emission Tomography;post-doctoral training;Posture;Prevention;Preventive Medicine;Prospective, cohort study;religious order study;Reporting;Research Personnel;risk stratification;Role;Sex Differences;skill acquisition;skills;social;Source;Standardization;Stroke;tau Proteins;Testing;Training;vascular risk factor;Visit;White Matter Hyperintensity;Work

PROJECT_TITLE: Epidemiologic, imaging and pathological studies of the role of blood pressure variability in dementia etiology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH The genetic program by which one multipotent cell gives rise to multiple cell types—skin, brain, liver, etc.—is largely unknown. To identify the molecular mechanisms by which genes are precisely controlled to successfully differentiate into specific cell types, we will leverage 3-dimensional genome technologies that can probe which loci are closely interacting in nuclei. A combination of hybrid mouse models, advanced experimental techniques, and new algorithms will likely reveal a new paradigm of dynamic gene regulation during development.

PI_NAMEs: KIM, MINJI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: 3-Dimensional;Algorithms;Alleles;Architecture;autism spectrum disorder;autosome;Bar Codes;Behavior;Binding;Binding Proteins;Brain;CCCTC-binding factor;Cell Culture Techniques;Cell Differentiation process;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Chromatin Loop;Chromosomes;Communication;Complex;Computational algorithm;Crossbreeding;Data;Data Analyses;Data Set;daughter cell;Defect;Development;Developmental Biology;developmental disease;Dimensions;Diploidy;Disease;Dominant Genes;Downstream Enhancer;Drops;Ectoderm;Embryo;Encapsulated;Endoderm;Enhancers;Epigenetic Process;Event;Experimental Designs;experimental study;Future;gastrulation;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Genome;Genome Mappings;genome-wide;genomic data;Genomic Imprinting;Graph;graph theory;Harvest;Health;Heterogeneity;high dimensionality;High-Throughput Nucleotide Sequencing;Human;human genome sequencing;Hybrids;imprint;improved;In Vitro;Inbred Strain;Individual;insertion/deletion mutation;insight;Knowledge;Laboratory mice;Link;Liver;Mammals;Maps;Measures;Mediating;Mentors;Mesoderm;Methods;Methylation;Microfluidics;Molecular;Mouse Embryonic Stem Cells;mouse model;Mouse Strains;multipotent cell;Mus;Mutate;Nature;Organism;Partner in relationship;Pattern;Phase;Population;prevent;Process;programs;promoter;Proteins;Public Health;Regulatory Element;Reproducibility;Research Personnel;Resolution;RNA Polymerase II;Role;Schizophrenia;signal processing;single molecule;Skin;stem cells;System;Techniques;Technology;Testing;Therapeutic Intervention;three-dimensional modeling;Time;tissue repair;Tissues;Training;Transcriptional Regulation;transcriptome sequencing;Variant;Visualization;Walking;Work

PROJECT_TITLE: Roles of allele-specific chromatin interactions in transcription regulation during development


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Orientia tsutsugamushi is an understudied bacterial pathogen and global health threat that causes the potentially deadly infection, scrub typhus, which afflicts at least one million people each year. This project will address a major technical gap in the field by developing tools for genetically manipulating O. tsutsugamushi. These tools will ultimately enable us and other researchers to better understand how this microbe causes disease and may identify novel targets for treating scrub typhus.

PI_NAMEs: CARLYON, JASON A (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acceleration;Alleles;Antibiotics;Bacteria;Biological Assay;Blood Vessels;Catalogs;Cell Physiology;Cells;Cellular biology;Chloramphenicol;Chromosomes;Complement;Complex;Death Rate;Development;Disease;Electroporation;Endothelial Cells;Ensure;Essential Genes;Etiology;Fever;Fluorescence-Activated Cell Sorting;Foundations;Gene Expression;gene function;Genes;Genetic;genetic manipulation;global health;Human;In Vitro;in vivo;Infection;interest;Intervention;Invaded;Knock-out;knockout gene;Leukocytes;Libraries;Ligands;Microbe;mouse model;Multiple Organ Failure;Mutagenesis;mutant;neglect;novel;Organism;Orientia tsutsugamushi;pathogen;Pathogenesis;pathogenic bacteria;Persons;Phase;Phenotype;protein expression;Proteins;Protocols documentation;Public Health;Publishing;Reporting;Research;Research Personnel;Rickettsia;Scrub Typhus;Series;stem;Study models;success;System;Time;tissue culture;tool;Transferase;Transgenic Organisms;Vaccines;Virulence;Virulence Factors;Work

PROJECT_TITLE: Development of genetic tools for Orientia tsutsugamushi

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 FDS-M (S1)]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE We aim to develop novel, non-invasive, clinically relevant magnetic resonance imaging (MRI) technologies to visualize therapeutic cell distribution and homing following systemic administration. If successful, the proposed work will provide scientists and clinicians with powerful and clinically translatable imaging tools to assess cell homing, survival and therapeutic efficacy and the means to accelerate therapy development.

PI_NAMEs: CHAPELIN, FANNY  (contact)

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Acceleration;Acute;allograft rejection;bench to bedside;Biodistribution;Biological Markers;Blood;cancer cell;Cardiotoxicity;CD34 gene;Cell Separation;Cell Therapy;cell type;Cells;Chronic;Clinical;clinical application;Clinical Research;clinical translation;clinically relevant;Contrast Media;cytokine;Development;Devices;Diabetes Mellitus;disease model;Dose;end-stage organ failure;Evaluation;experience;FDA approved;Goals;Growth;Homing;Human;IL2RA gene;Image;image guided;Imaging Device;imaging modality;Imaging technology;Immunocompromised Host;Immunosuppression;Impairment;improved;In Vitro;in vivo;Incubated;individual patient;Infusion procedures;Intravenous;iron oxide;Label;Legal patent;Leukapheresis;Life;Liver;Magnetic Resonance Imaging;Manufacturer;Methods;Microspheres;Minor;Modeling;Monitor;Morbidity - disease rate;mouse model;Mus;nephrotoxicity;novel;organ transplant recipient;Organ Transplantation;Outcome;Patients;Phenotype;prevent;Process;Property;Protocols documentation;Protons;Publishing;Quality of life;Radiation;Regimen;Regulatory T-Lymphocyte;Risk;Scientist;side effect;Signal Transduction;Skin graft;Skin Transplantation;Solid;Spleen;stem cells;T-Lymphocyte;Techniques;Technology;Testing;Therapeutic;Therapeutic Uses;therapeutically effective;therapy development;Time;Tissues;Toxic effect;Transfection;Translating;translational potential;Transplant Recipients;Transplantation Surgery;Transplantation Tolerance;Treatment Efficacy;Treatment Protocols;Visualization;Work

PROJECT_TITLE: Magnetic resonance imaging methods to track Treg distribution and homing for clinical applications

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: TAMPA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Enhancer RNAs (eRNAs) are a new class of noncoding RNAs that play important roles in long-range chromatin interactions and gene regulation. In this project, we will map eRNAs and enhancer-promoter interactions using an unbiased approach, on a genome-wide scale, in the hypoperfused adult hippocampus leading up to vascular dementia. This work will lay the foundation for in-depth studies to understand eRNA functions and potentially identify novel therapeutic opportunities against hippocampal damage and vascular dementia.

PI_NAMEs: DHARAP, ASHUTOSH  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: 3-Dimensional;Adult;Alzheimer's disease related dementia;Behavioral;Bilateral;Biology;Brain;Brain Injuries;Carotid Stenosis;Catalogs;cdc Genes;Cell Cycle Arrest;Cerebral cortex;cerebral hypoperfusion;Cerebral Ischemia;Cerebrovascular Trauma;ChIP-seq;Chromatin;cohort;Data;Data Set;Development;Disease;DNA;DNA mapping;Enhancers;Estrogens;Euthanasia;experience;experimental study;Female;Foundations;Functional disorder;Funding Opportunities;Future;Gene Expression;Gene Expression Regulation;gene interaction;gene network;gene regulatory network;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome-wide;genomic locus;Goals;Hi-C;hippocampal atrophy;Hippocampus;hypoperfusion;Immediate-Early Genes;Injury;innovation;Ischemia;Ischemic Brain Injury;Macrophage;male;Maps;Methods;middle age;Modeling;mouse model;Mus;neuron loss;Neurons;neuroprotection;novel;novel therapeutics;Outcome;Pathologic;Pathway interactions;Pattern;Phenotype;Physiological;Pilot Projects;Play;post stroke;Process;programs;promoter;Reperfusion Therapy;Reporting;Research;Research Personnel;response;RNA;Role;sex;spatiotemporal;Standardization;Stimulus;Testing;therapeutic RNA;Time;timeline;TP53 gene;Transcript;Transcriptional Activation;transcriptome sequencing;Untranslated RNA;Vascular Dementia;vascular injury;virtual;Work

PROJECT_TITLE: Enhancer RNAs and enhancer-centric gene regulatory networks in vascular dementia

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Narrative Evidence suggests that, if the low balance confidence of those with chronic stroke is not addressed, the benefits of improved walking ability on daily activity won’t be realized. This proposal seeks to identify distinct types of balance confidence within a commonly used questionnaire, and then determine how those categories of balance confidence relate to walking activity in those with chronic stroke. This is an analysis of existing data that will inform the specific ways we can improve balance, raise balance confidence, and enable more walking.

PI_NAMEs: CRENSHAW, JEREMY RICHARD (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: Accounting;Activities of Daily Living;Address;Age;Categories;chronic stroke;Clinical;Clinical Trials;Conduct Clinical Trials;Data;Delaware;Environment;Equilibrium;Factor Analysis;falls;Frequencies;Goals;Health;Impairment;improved;Individual;Intervention;Link;Measurement;Measures;Mediating;modifiable risk;Monitor;Multi-Institutional Clinical Trial;Musculoskeletal Equilibrium;neuromuscular;Numerical value;Outcome;Patient Self-Report;Persons;Physical activity;post stroke;Posture;Questionnaires;Reaction;Recommendation;Recurrence;Registries;Rehabilitation therapy;Research;Risk;Risk Factors;secondary analysis;sedentary lifestyle;Self Efficacy;sensor;sex;Specificity;Speed;Stroke;Surveys;Testing;Time;tool;Translating;Universities;Walking;walking speed;Work

PROJECT_TITLE: A domain-specific approach to falls efficacy and walking activity in individuals with chronic stroke

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Function, Integration, and Rehabilitation Sciences Study Section[CHHD-K]


ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: RELEVANCE TO PUBLIC HEALTH Blood transfusion is the most commonly performed hospital procedure worldwide. Despite standard, FDA- mandated expiration dates, red blood cell units deteriorate at varying rates, increasing the risk of adverse transfusion outcomes for vulnerable populations. We are developing a point-of-care, contact-free assay to evaluate stored blood quality prior to transfusion, which will transform clinical practice by implementing a precision medicine approach to transfusion efficacy.

PI_NAMEs: KARAFIN, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: Accounting;Acoustics;Age;aged;Anticoagulation;Attenuated;attenuation;Biohazardous Substance;Biological Assay;Blood;Blood coagulation;Blood Donations;Blood donor;blood product;Blood specimen;Blood Transfusion;Cell Membrane Permeability;Characteristics;Classification;Clinical;clinical efficacy;clinical practice;Clinical Trials;clinically relevant;comparative;Data;design;Deterioration;Development;Elasticity;elastography;Enrollment;Erythrocyte Transfusion;Erythrocytes;Evaluation;expiration;Favorable Clinical Outcome;flexibility;Future;Guidelines;Hemoglobin;Hospitals;Human;Image;indexing;Knowledge;Life;Liquid substance;Measurable;Measures;Microcirculation;Monitor;Observational Study;Outcome;Participant;Patients;personalized approach;Pilot Projects;point of care;Polyvinyl Chloride;precision medicine;preservation;Procedures;Public Health;Publishing;Radiation;Refrigeration;Relaxation;Risk;screening;signal processing;Signal Transduction;soft tissue;Solid;solid state;Sterility;Techniques;Therapeutic;Time;Tissues;Transfusion;transmission process;ultrasound;United States;Variant;viscoelasticity;Viscosity;Vulnerable Populations;Work

PROJECT_TITLE: Development of a contact-free assay to evaluate stored blood quality using ultrasound viscoelasticity techniques

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Advanced solid cancers, such as rare ovarian cancer sub-types, are treated with cisplatin-based regimens, but the response is poor and not durable, and most patients die. These cancers still harbor the normally apoptotic wild-type p53 gene but display substantial resistance due to defective p53 phosphorylation, and we strongly believe that restoring this post-translational phosphorylation will reactivate wild-type p53 and permit rational therapies to emerge. Our proposed novel studies, therefore, will investigate whether transcriptional targeting of MDM4 will expose the p53 phospho-site to an active endogenous kinase and restore p53 phosphorylation, enhance p53 activity, contribute to synergy with cisplatin and, thereby, induce strong antitumor activity.

PI_NAMEs: SIDDIK, ZAHID H (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute;Age;alpha helix;antitumor effect;Apoptosis;Apoptotic;Awareness;Biochemical;Cancer Model;Cancer Patient;cancer subtypes;Cell Line;Cells;Cessation of life;Chemicals;Cisplatin;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Defect;design;Development;Diagnosis;Disease;Docking;Down-Regulation;EP300 gene;Exposure to;Follow-Up Studies;Foundations;Future;Genes;Genetic Transcription;genotoxicity;Genotype;Goals;Greater sac of peritoneum;Growth;high risk;Human;Immunohistochemistry;improved;In Vitro;in vitro Model;in vivo;inhibitor;innovation;Intravenous;knock-down;Knock-out;Knowledge;Legal patent;Malignant neoplasm of ovary;Malignant Neoplasms;MDM2 gene;Mesothelioma;Modeling;Molecular;Monitor;mutant;Mutation;N-terminal;nanoparticle delivery;neoplastic cell;Nodule;novel;novel strategies;Nude Mice;Osteosarcoma;Outcome;Ovarian Clear Cell Tumor;ovarian neoplasm;Patients;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;prevent;recruit;Refractory;refractory cancer;Refractory Disease;Regimen;Reporting;Research;Resistance;response;response biomarker;restoration;Role;Serous;Site;Small Interfering RNA;Solid;success;synergism;System;Tail;targeted treatment;Testing;Therapeutic;therapeutic target;Therapeutic Uses;tool;TP53 gene;Transactivation;Treatment outcome;tumor;tumor growth;Tumor Subtype;Western Blotting;Work;Xenograft procedure;young woman

PROJECT_TITLE: Targeting MDM4 in Rare Refractory Ovarian Cancer Sub-Types

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-S (O1)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

PHR: The studies proposed in this application will advance understanding of genes that contribute to the severity of bleeding and blood clotting in a number of important human diseases, leading to improved diagnosis. This work will also lay the groundwork for the development of new therapies. In addition, these studies will advance basic knowledge of how proteins work and how they are manufactured in our cells, identifying opportunities for the development of novel therapies in the future.

PI_NAMEs: GINSBURG, DAVID  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Amino Acid Substitution;Area;Blood coagulation;Cells;Cholesterol;Clinical;Data;Data Set;Development;Diagnosis;Directed Molecular Evolution;Disease;Endothelial Cells;Endothelium;Factor V;Factor VIII;Future;Gene Expression;Gene Family;Genes;Genetic Diseases;Genome;genome sequencing;Golgi Apparatus;Hemolytic-Uremic Syndrome;Hemorrhage;Hemostatic Agents;Hemostatic function;Heterogeneity;Human;human disease;improved;in vivo;Inherited;insight;Knowledge;lipid metabolism;manufacture;member;Methods;Modeling;Molecular Genetics;mouse model;Mus;Mutation;mutation screening;novel;novel therapeutics;Pathogenesis;Patients;Peptide Hydrolases;Plasma;Plasminogen Activator Inhibitor 1;precision medicine;Predisposition;programs;Property;Protein Secretion;protein structure;Proteins;Reagent;receptor;Regulation;Research;Resources;Role;Serine Proteinase Inhibitors;Severities;Specificity;Structure-Activity Relationship;Thrombocytopenic Purpura;Thrombosis;Thrombotic Thrombocytopenic Purpura;vascular bed;Vascular Diseases;von Willebrand Factor;Work

PROJECT_TITLE: The Molecular Genetics of Hemostasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O1)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: GALVESTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: PROJECT NARRATIVE Scrub typhus is an emerging acute febrile illness with high fatality, with an estimated one billion people at risk of infection and more than one million cases reported annually. It remains unclear as to how Orientia bacteria invade host cells and elicit damage; no vaccines are available. This project is aimed at generating genome-wide mutant library in Orientia and characterizing host immune responses in animal models by using trackable mutants.

PI_NAMEs: NARRA, HEMA PRASAD (contact);SOONG, LYNN

PROJECT_TERMS: Acute;Address;African;Ally;Anaplasma;Animal Model;Ankyrin Repeat;Annual Reports;Antibiotics;Antigenic Variation;Area;Asia;Bacteria;Bacterial Genome;Biological Assay;Biology;Bioluminescence;Case Study;Cell Line;Cell Separation;Cells;Chemicals;Chromosomes;Classification;Codon Nucleotides;Communities;Contact Inhibition;Country;Cytosol;Death Rate;Defect;Development;Diagnosis;Diagnostic;Disease;DNA Transposable Elements;Drug Targeting;Ehrlichia;Electroporation;empowerment;Endothelial Cells;Family;Family member;Fever;Fluorescence;forward genetics;Foundations;Future;Gene Deletion;Generations;Genes;Genetic;genetic manipulation;Genome;genome-wide;genomic locus;Goals;Gram-Negative Bacteria;Growth;homologous recombination;Image;Immune response;Immunology;In Vitro;in vivo;Inbred Mouse;Incidence;Individual;Infection;infection risk;insight;Invaded;Investigation;Kinetics;Knowledge;Latin America;Libraries;Life;Link;Macrophage;member;Middle East;Modeling;Molecular;mortality;mouse model;Multiple Organ Failure;Mutagenesis;mutant;neglect;novel;novel therapeutics;Orientia tsutsugamushi;pathogen;Pathogenesis;Phase;Pilot Projects;Plaque Assay;Plasmids;Populations at Risk;Predisposition;preservation;Primary Cell Cultures;Protein translocation;Proteins;Protocols documentation;Reporting;Research;Research Personnel;Rickettsia;Rickettsia conorii;Rickettsiaceae;Role;Route;Scrub Typhus;Series;Shuttle Vectors;Soldier;Solid;Systemic infection;Tertiary Protein Structure;Testing;therapeutic development;Tissues;tool;transgene expression;vaccine access;Vaccines;Vascular Diseases;Vietnam;Virulence;Virulent;War;World War II

PROJECT_TITLE: Generation of Orientia tsutsugamushi mutant strains for pathogenesis research


NIH_SPENDING_CATS: Antimicrobial Resistance;Eye Disease and Disorders of Vision;Genetics;Infectious Diseases

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Pseudomonas aeruginosa is the most common cause of bacterial eye infections worldwide, with the potential to cause blindness. We are proposing to study how a class of strains that produce a specific virulence determinant, ExoU, which is linked to the most severe corneal infections and also increased antibiotic resistance, cause disease.

PI_NAMEs: RIETSCH, ARNE  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Animal Model;Antibiotic Resistance;Automated Annotation;Bacteria;Bacterial Eye Infections;Blindness;Caenorhabditis elegans;Cells;Characteristics;Clinic;Cornea;Curiosities;cystic fibrosis patients;Cytolysis;Cytoplasm;cytotoxicity;Data;Disease;Environment;Epidemiology;Epithelial Cells;Frequencies;Genes;Genome;Goals;high risk;Impairment;In Vitro;in vivo;Infection;Invaded;Island;Keratitis;Link;lysine-tRNA;Modeling;Molecular;Multi-Drug Resistance;mutant;neutrophil;novel;Pathogenesis;pathogenic bacteria;Pathogenicity;Pathogenicity Island;Patients;Phenotype;Play;Production;programs;Protein Inhibition;Proteins;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Reporting;Research;resistant strain;Role;Severity of illness;success;Surface;Syringes;Testing;Tissues;Toxin;Type III Secretion System Pathway;ventilator-associated pneumonia;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Role of ExoU island accessory genes in P. aeruginosa virulence

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Bacteria in the genus Rickettsia include tick-borne human pathogens that can only grow inside of eukaryotic host cells. Though they cause significant human disease, our understanding of the basic biology of Rickettsia species is limited. This project aims to generate a large collection of mutants of the tick-borne human pathogen Rickettsia parkeri to enable studies that inform new strategies to limit spread of and infection by these bacteria.

PI_NAMEs: GOLEY, ERIN D (contact)

PROJECT_TERMS: Address;Alphaproteobacteria;amidase;Anti-Bacterial Agents;Arthropods;Bacteria;Bacterial Infections;Bar Codes;Biochemical;Biological;Biological Assay;Biology;Cell Cycle Progression;Cell division;Cell Separation;Cell Shape;Cell Wall;Cells;Cellular Morphology;Characteristics;Code;Collection;Defect;design;Development;Disease;DNA;Effector Cell;Enzymes;Epidemiology;Event;gene complementation;Gene Expression;gene function;Generations;Genes;Genetic;genetic manipulation;genetic resource;Genome;Growth;Health;Human;human disease;human pathogen;Hydrolysis;Image;improved;insight;interest;Investigation;Kinetics;Knowledge;Libraries;Life;Life Style;Maps;Mediating;Metabolic;Methods;Modeling;Molecular;Morphology;Mutagenesis;mutant;Mutation;Organism;Outcome;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Peptidoglycan;Phase;Phenotype;Physiological;Plasmids;population based;Population Growth;protein degradation;Proteins;Research;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Rocky Mountain Spotted Fever;Role;screening;Shapes;Signal Transduction;spotted fever;targeted treatment;Therapeutic;Therapeutic Intervention;tick-borne;tool

PROJECT_TITLE: Generation and characterization of a large-scale transposon mutant library of Rickettsia parkeri


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE This project will advance the science of precision delivery of care for community-dwelling people living with chronic lung disease. We will refine and pilot clinical prediction models that rely on electronic health record data to identify those who may benefit from frailty- or depression-focused interventions. The results from these preliminary studies, intended to establish the feasibility and equity of these predictive tools, will lay the groundwork for larger-scale testing in a future randomized trial.

PI_NAMEs: WEISSMAN, GARY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: acceptability and feasibility;Acute;acute care;Admission activity;Adult;Age;Algorithms;Artificial Intelligence;barrier to care;Calibration;candidate identification;care delivery;career development;Caregivers;Caring;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical care;Clinical Data;clinical decision support;Clinical Decision Support Systems;clinical encounter;clinical predictive model;clinical predictors;Clinical Trials;clinically actionable;Communities;Community Healthcare;cost;dashboard;Data;data pipeline;Data Science;Data Set;Data Sources;demographics;Development;Diagnosis;Electronic Health Record;Electronics;Equity;Ethics;experience;Feedback;frailty;Funding;Future;Gender;health care disparity;health management;Health system;hospital readmission;Hospitalization;improved;indexing;Inequity;innovation;Interstitial Lung Diseases;Intervention;Interview;Knowledge;Laboratories;laboratory experience;Lead;Life;Light;Link;machine learning model;Measures;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Mission;Modeling;Morbidity - disease rate;mortality;Outpatients;Output;Patient-Focused Outcomes;Patients;Performance;Persons;Pilot Projects;Population;population health;Positioning Attribute;predictive modeling;predictive tools;Probability;Process;Process Measure;Protocols documentation;Quality of life;Race;randomized trial;randomized, clinical trials;Reporting;Research Personnel;Resources;response;Risk;Risk Factors;Science;secondary analysis;Secure;Source;Structure;structured data;Subgroup;support tools;Surveys;Technology;Testing;Text;Time;tool;Translating;treatment adherence;United States;unstructured data;Update;Visual;Work

PROJECT_TITLE: Building equitable and feasible clinical decision support tools for population health management of people living with chronic lung disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O2)]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome;Prevention;Sexually Transmitted Infections;Women's Health Research

PHR: PROJECT NARRATIVE Mucosal viruses interact with resident bacteria and these interactions influence infectivity and replication of the viruses. This proposal will explore the role of vaginal bacteria and bacterial cell wall components in inhibiting herpes simplex virus infection.

PI_NAMEs: GOPINATH, SMITA  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Affect;Age;antiviral immunity;Bacillus subtilis;Bacteria;Bacterial Vaginosis;Bacteriophages;Binding;Biology;Cell surface;Cell Wall;Cells;Child Health;Clinic Visits;Clinical;Data;Diagnosis;Disease;Enzyme-Linked Immunosorbent Assay;Epithelium;experimental study;genital herpes;Genitalia;Goals;Gram-Positive Bacteria;Health;Herpes Simplex Infections;Herpesviridae Infections;HIV;Human;Human Herpesvirus 2;Immune;Immune response;Immunologic Receptors;improved;In Vitro;in vivo;Incubated;Individual;Infection;innate immune sensing;Intestines;knock-down;Knockout Mice;Laboratory Finding;Lactic acid;Lactobacillus;Lactobacillus reuteri;Link;lytic replication;Mediating;Metabolic;Methods;microbicide;microbiome;mouse model;Mucous Membrane;neonatal infection;neonate;Neurons;novel;Nucleotides;Patients;Peptidoglycan;Persons;Play;predictive modeling;prevent;Proteins;receptor expression;reproductive;reproductive tract;Risk;Role;Sampling;sensor;Simplexvirus;Structure;Testing;TLR2 gene;transmission blocking;transmission process;Travel;Ulcer;Vaccines;Vagina;vaginal fluid;vaginal lactobacilli;vaginal microbiome;vaginal mucosa;Viral;Virion;Virus;Virus Diseases;Virus Replication;Virus Shedding;Woman;Work

PROJECT_TITLE: Bacteria-Virus interactions in genital herpes infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IMII-U (01)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Nutrition;Prevention;Social Determinants of Health;Telehealth

PHR: Project Narrative National treatment guidelines recommend the DASH (Dietary Approaches to Stop Hypertension) eating pattern as first-line treatment option for adults with hypertension; however, adherence to the DASH eating pattern is exceptionally low and foods that align with the DASH eating pattern are inaccessible for many within this population. Our current proposal will test the feasibility of using commercially available grocery delivery services, simultaneous to a robust behavioral intervention, to improve food access and adherence to the DASH eating pattern among adults with hypertension and low access to high quality food. If feasible, this approach can be scaled and used to improve access to an evidence-based hypertension treatment across the U.S.

PI_NAMEs: BENNETT, GARY G;MILLER, HAILEY  (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Address;Adherence;Adopted;Adult;Affect;American;behavior change;Behavior Therapy;behavioral health intervention;Behavioral Mechanisms;Blood Pressure;Cellular Phone;Censuses;Clinical;Communities;comorbidity;comparison group;cost;DASH diet;Diastolic blood pressure;Diet Modification;dietary;Dietary Intervention;dietary requirement;digital;digital health;Eating;efficacy testing;Equity;ethnic minority;evidence base;experience;feasibility testing;Feedback;Food;Food Access;food quality;Future;Goals;Health;Health Promotion;Home;Hypertension;hypertension control;hypertension treatment;Improve Access;improved;Individual;Infrastructure;innovation;Intervention;Intervention Trial;Interview;lens;Low income;member;Monitor;National Institute of Nursing Research;Neighborhoods;novel strategies;Ownership;Parents;Participant;participant retention;Patients;Pattern;Population;population health;Positioning Attribute;Price;racial minority;Randomized;Recommendation;Research;service delivery;Signal Transduction;skills training;smartphone application;social determinants;Supermarket;Techniques;Technology;technology platform;Testing;tool;Training and Education;Transportation;treatment arm;treatment guidelines;Underserved Population;United States Department of Agriculture;uptake;web app

PROJECT_TITLE: Feasibility of delivering a digital health intervention to improve food access and dietary quality among adults with hypertension

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Infectious Diseases;Lung;Patient Safety;Racial and Ethnic Minority Health Research;Rare Diseases;Sepsis;Social Determinants of Health

PHR: Project narrative. Inequitable clinical outcomes have been well documented for minoritized patients with acute respiratory failure and sepsis. However, due to limited understanding of the mechanisms that give rise to these disparities, interventions to successfully mitigate them have yet to be developed. This proposal will use mixed qualitative and quantitative methods to clarify the mechanistic roles of underexplored and novel determinants of acute respiratory failure and sepsis disparities, thereby informing the design of interventions to end these disparities.

PI_NAMEs: CHESLEY, CHRISTOPHER FRANCIS (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute respiratory failure;Address;Admission activity;Adult;care delivery;career;career development;Caring;Censuses;Characteristics;Clinical;cohort;Critical Care;Critical Illness;Debility;Dedications;Development;Development Plans;Disease;Disparity;disparity elimination;disparity reduction;Elements;Environment;Equity;ergonomics;food desert;Funding;Goals;health determinants;health disparity;health equity;Health system;Home;hospital organization;hospital readmission;Hospitalization;Hospitals;Human;implementation barriers;Imprisonment;Inequity;Influentials;innovation;Institutional Practice;Interdisciplinary Study;Intervention;Interview;K-Series Research Career Programs;Knowledge;Length of Stay;Lung;Maps;Measures;Mediating;Mediation;Medically Underserved Area;Mentors;Methodology;Methods;Minority;minority patient;minority-serving hospitals;Modeling;mortality;multidisciplinary;Neighborhoods;novel;Outcome;outcome disparities;Pathway interactions;Patient Discharge;Patients;Pennsylvania;Physicians;Play;Pollution;Population Intervention;Process;Race;racial disparity;readmission risk;Recommendation;Records;Research;Research Design;Research Personnel;Resources;Risk Adjustment;Role;Sampling;Sepsis;skill acquisition;skills;socioeconomic disadvantage;socioeconomics;stem;Structure;success;Surveys;Survivors;System;Testing;theories;therapy design;therapy development;Training;United States;United States Centers for Medicare and Medicaid Services;Universities;Variant;Work;Writing

PROJECT_TITLE: Investigating mechanisms of disparities for critically ill patients with acute respiratory failure and sepsis.

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-O (O3)]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE The proposed study will identify the cellular membrane protein(s) that interact with the KIAA0319L protein, the multi-serotype AAV receptor (AAVR), and will reveal the entry and intracellular trafficking pathways of rAAV that are led by the complex of AAVR and AAVR-interacting proteins (AAVR-IP), which will help increase the gene delivery efficiency using rAAV vectors in human gene therapy.

PI_NAMEs: QIU, JIANMING  (contact)

PROGRAM_OFFICER_NAME: LINDE, AMBER SHRYER

PROJECT_TERMS: adeno-associated viral vector;Affinity;Antibodies;Binding;Binding Proteins;Biochemical;Biochemistry;Biological Assay;Biology;Blindness;Capsid;Categories;Cell membrane;Cell Membrane Proteins;Cell Nucleus;Cell surface;Cells;Cellular Membrane;Clathrin;Clinical;Clinical Trials;Collaborations;Complex;Cysteine;Cystine;Cytoplasmic Vesicles;delivery vehicle;Development;Dissociation;ds-DNA;Endocytic Vesicle;Endocytosis;Endocytosis Pathway;experimental study;Extracellular Domain;Fibroblast Growth Factor Receptor 1;Gene Delivery;Gene Expression;gene therapy;Genetic Transcription;Genome;glycosylation;Goals;Hemophilia A;Heparan Sulfate Proteoglycan;Heterodimerization;Homodimerization;Homologous Gene;Human;In Vitro;Inherited;Integral Membrane Protein;Integrins;Isoelectric Point;Knock-out;Lamins;Mediating;Membrane Glycoproteins;Membrane Proteins;Molecular Weight;Mus;Nature;Nuclear;Nuclear Import;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;Physiological;Play;Polycystic Kidney Diseases;Polysaccharides;Productivity;protein complex;Proteins;receptor;Receptor-Interacting Protein;Recombinant adeno-associated virus (rAAV);Recombinants;Recycling;Resistance;retrograde transport;Role;Route;RPE65 protein;Serotyping;Single-Stranded DNA;Spinal Muscular Atrophy;Tail;Testing;Therapeutic;tissue tropism;Tissues;trafficking;trans-Golgi Network;Transmembrane Domain;Tropism;Variant;vector;Viral;Virus

PROJECT_TITLE: Studies of the KIAA0319L-mediated productive transduction pathways of rAAV vectors

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Cardiopulmonary Toxicity of Electronic Nicotine Delivery Systems In the proposed studies, we will investigate the cardiovascular and pulmonary toxicity of ENDS using animal models and state-of-the-art exposure technology, protocols, and biomarkers of exposure and of harm. As such, we will directly address the Scientific Domain of Toxicity, and thus, will provide the FDA/CTP with rigorous and validated data to support policies regulating the design, manufacturing, and marketing of e-cigarette devices in order to protect public health.

PI_NAMEs: CONKLIN, DANIEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acrolein;Address;Aerosols;Affect;Animal Model;Biological Markers;biomarker identification;Carbon Monoxide;Cardiac;Cardiopulmonary;Cardiovascular Physiology;Cardiovascular system;Characteristics;combustible cigarette;Data;Dependence;design;Development;Devices;disorder risk;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic liquid;Electronic Nicotine Delivery Systems;Evaluation;evidence base;Exposure to;Flavoring;Formaldehyde;Generations;Health;hemodynamics;Individual;Link;Lung;manufacture;Marketing;Measures;Mediating;Metals;Modeling;Mus;Nicotine;nicotine exposure;novel;Pattern;pod mods;Policies;pollutant;Production;Propylene Glycols;Protocols documentation;Public Health;pulmonary function;Regulation;Risk;Role;Solvents;Tars;Technology;Testing;tobacco advertising;tobacco products;Toxic effect;United States Food and Drug Administration;Urine;vegetable glycerin;volatile organic compound;Work;young adult;Youth

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-E (56)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative: Orientia tsutsugamushi (O.t.) is an obligate intracellular pathogen and the etiological agent of scrub typhus, a potentially fatal disease that afflicts over one million people each year. The molecular details of how this important emerging pathogen co-opts the host are largely unknown, predominately due to a lack of tools for genetic manipulation of this significant human pathogen. The goal of our research is to develop genetic tools for use in O.t., which will serve as the first crucial step towards identifying bacterial and host factors that are necessary for O.t. pathogenesis.

PI_NAMEs: WEBER, MARY  (contact)

PROJECT_TERMS: Address;Africa;Amendment;Antibiotic Resistance;Asia;Bacteria;beta-Lactams;Biological Assay;Bite;Case Study;Cell Cycle;Cell Cycle Progression;Cells;Cessation of life;Chiggers;Chloramphenicol;Codon Nucleotides;Complement;Death Rate;Development;Diagnostic;Disease;Disease Outcome;DNA;DNA cassette;effective therapy;Electroporation;emerging pathogen;Encephalitis;Ensure;Environment;Epitopes;Etiology;Fluoroquinolones;Foundations;Genes;Genetic;genetic manipulation;Genetic Transformation;genome sequencing;global health;Goals;Hepatitis;Hospitals;Host Defense Mechanism;Human;human pathogen;Incidence;Individual;Infection;Integration Host Factors;Invaded;Isopropyl Thiogalactoside;Kidney Failure;Knock-out;Knowledge;Methods;Microscopy;Middle East;Molecular;Molecular Target;Morbidity - disease rate;Multiple Organ Failure;Mutagenesis;mutant;Mutation;Myocarditis;Natural Resistance;novel strategies;Organism;Orientia tsutsugamushi;overexpression;pathogen;Pathogenesis;Persons;Pharmaceutical Preparations;Phase;Plasmids;Play;Positioning Attribute;Proliferating;promoter;protein expression;Protein Overexpression;Protein Secretion;Proteins;Reagent;Reporting;Research;Research Personnel;resistant strain;Resources;Rickettsia rickettsii;Role;Rural;Scrub Typhus;Shuttle Vectors;Site;South America;statistics;System;Techniques;Testing;Tetracyclines;tool;transmission process;vaccine candidate;Vaccines;Virulence Factors;Western Blotting;whole genome

PROJECT_TITLE: Development of genetic tools for overexpression and targeted mutagenesis of Orientia tsutsugamushi TPR proteins


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: This project will evaluate a novel biocompatible nanomaterial in preclinical studies to allow its clinical translation for NIR fluorescence and MRI image-guided surgery and sonodynamic therapy of medulloblastoma (MB). Based on our strong preliminary data, we hypothesize that this multifunctional nanomaterial platform can be transported across the blood-brain barrier and accumulate in MB tumors to enable their multimodal detection and safer therapy using non-ionizing low-intensity ultrasound. Translating this technology to the clinic would be transformative in managing MB by significantly reducing morbidities associated with surgery and chemoradiotherapy of MB tumors.

PI_NAMEs: BARAJAS, RAMON FRANCISCO;YILDIRIM, ADEM  (contact)

PROGRAM_OFFICER_NAME: FOUNTAIN, JANE W

PROJECT_TERMS: Address;Aminolevulinic Acid;Animals;Beds;Binding;Biodistribution;biomaterial compatibility;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain tissue;Cancer Biology;cancer cell;Cancer Etiology;Cells;chemoradiation;chemotherapy;Childhood;childhood cancer mortality;Clinic;Clinical;clinical translation;Clinical Trials;Complex;Contrast Media;Data;Detection;Development;Diagnosis;Disease;Dose;Drug Kinetics;early phase clinical trial;Ensure;Evaluation;Excision;experience;experimental study;FDA approved;Fluorescence;Future;Gadolinium;Gadovist;Generations;Glioblastoma;Goals;Image;image guided;Image-Guided Surgery;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Indocyanine Green;innovation;Life Experience;Lipoproteins;Long-Term Survivors;Low Density Lipoprotein Receptor;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Mediating;Medulloblastoma;Methods;Microscopic;Modeling;molecular imaging;Morbidity - disease rate;Multimodal Imaging;multimodality;nanomaterials;Nature;near infrared dye;Near-infrared optical imaging;Neurologic;novel;Operative Surgical Procedures;overexpression;Patients;Peptides;Performance;Pharmaceutical Preparations;pre-clinical;preclinical study;preservation;Primary Brain Neoplasms;Quality of life;Radiation;Rattus;Reactive Oxygen Species;Regimen;Research;Residual Neoplasm;Residual state;Risk Reduction;Scheme;Second Primary Cancers;self assembly;Solid Neoplasm;success;Survival Rate;Survivors;Technology;Testing;Therapeutic;Time;Tissues;Toxic effect;transcytosis;Translating;tumor;Ultrasonic Therapy;ultrasound;uptake;Work

PROJECT_TITLE: A multifunctional nanomaterial platform for reducing morbidity in medulloblastoma therapy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Substance Misuse

ORG_CITY: Greenville

ORG_NAME: AMALGENT THERAPEUTICS, INC.

ORG_STATE: NC

PHR: NARRATIVE The high doses of opioids needed for effective pain relief have contributed to an epidemic of abuse in the United States. Amalgent Therapeutics, Inc. proposes to develop a novel combination drug that provides pain relief with a significantly improved risk-benefit compared to opioid monotherapy. The proposed drug will benefit patients by providing pain relief while decreasing the potential for addiction.

PI_NAMEs: MEYN, MALCOLM A (contact)

PROGRAM_OFFICER_NAME: NGUYEN, TAM L

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acceleration;Acute Pain;addiction;addiction liability;Address;Adjuvant;Adverse effects;adverse event risk;American;Analgesics;Animal Model;Behavior;Benefits and Risks;Clinic;Clinical;Clinical Data;clinical development;clinically relevant;Complex;Constipation;Data;Dependence;Development;Dose;dose information;Drug Combinations;drug development;Effectiveness;Epidemic;Face;FDA approved;Guidelines;improved;innovation;insight;Lethargies;Marketing;Mental Depression;Modeling;Morphine;Nausea;New Drug Approvals;new technology;novel;novel drug combination;novel therapeutics;Opiate Addiction;opiate tolerance;Opioid;Opioid Analgesics;opioid epidemic;opioid therapy;opioid use;opioid use disorder;Oral;Pain;Pain management;pain patient;pain relief;painful neuropathy;Parkinson Disease;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Physicians;Postoperative Pain;pramipexol;prescription opioid;prescription opioid abuse;prevent;Program Development;Property;Psyche structure;Regulatory Pathway;Research;research and development;research clinical testing;Rewards;Risk;risk minimization;Risk Reduction;Safety;side effect;Small Business Innovation Research Grant;Surgical incisions;Surgical Models;Tablets;Technology;Therapeutic;Therapeutic Index;therapeutic opioid;United States;Ventilatory Depression;willingness;Work

PROJECT_TITLE: Mechanism and Efficacy of a Novel Opioid Adjuvant

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SAI-S (A1)]


NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Lay summary. Infections with respiratory viruses had unprecedented effects on human health leading to increase use of critical care resources and mortality, especially among elders. In this project, we will use our biorepository of lower airway and blood samples as well as data accessible to us to explore novel ways to determine age-related molecular signatures that uncover novel pathways that lead to poor clinical outcomes.

PI_NAMEs: FORST, CHRISTIAN ;SEGAL, LEOPOLDO NICOLAS (contact);ZHANG, BIN

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: 2019-nCoV;Age;age difference;age group;age related;Aggressive Clinical Course;Aging;Anti-Inflammatory Agents;biobank;Blood;Blood specimen;Cells;Classification;Clinical;clinical phenotype;Clinical Trials;cohort;Collaborations;Comparative Study;COVID-19;COVID-19 pandemic;COVID-19 patient;Credentialing;Critical Care;Critical Illness;Data;data integration;Data Set;design;Disease;Down-Regulation;Elderly;Event;experience;gene network;Goals;Health;Healthcare Systems;Hospitalization;host-microbe interactions;Human;IL6 gene;Immune;Immune response;Immunoglobulin G;Immunologics;Infection;Inflammatory;Inflammatory Response;influenza infection;inhibitor;Injury;insight;Integration Host Factors;Interferons;Investigation;microbial;Molecular;Molecular Profiling;Monoclonal Antibodies;mortality;multiple omics;network models;novel;older patient;Outcome;Pathway interactions;Patients;Pattern;Persons;Pharmaceutical Preparations;Process;Prognosis;Publications;Reporting;resilience;Resources;Respiratory Failure;respiratory infection virus;respiratory virus;response;Sampling;SARS-CoV-2 immune response;SARS-CoV-2 infection;Severities;Signal Transduction;single-cell RNA sequencing;Steroids;Subgroup;Testing;Time;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Viral;Viral Load result;Viral Respiratory Tract Infection;Virus Replication;young adult

PROJECT_TITLE: Age related loss of immune resilience during response to severe respiratory viral infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 VSR-I (S1)]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Gene Therapy;Genetics;Kidney Disease;Pediatric;Polycystic Kidney Disease;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE Preventing or mitigating cystogenesis is crucial to the long-term survival and quality of life of patients with polycystic kidney disease (PKD). Our approach focuses on targeting a single noncoding RNA to manipulate multiple genes, proteins, and pathways. Should we succeed, it would open the door for exploring the therapeutic potential of inhibiting PVT1 and reducing c- MYC levels to ameliorate cystogenesis in ADPKD.

PI_NAMEs: ABOUDEHEN, KARAM  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Ablation;Affect;Age Months;American;Autosomal Dominant Polycystic Kidney;c-myc Genes;Categories;Code;Collaborations;cost effective;CRISPR/Cas technology;Cyst;Cystic kidney;Data;Dependovirus;Development;Disease;Embryo;Epigenetic Process;Epithelial Cells;Epithelium;Exons;Foundations;Functional disorder;Future;Gene Expression;Genes;Genetic Crosses;genetic manipulation;Growth;Human;human embryonic stem cell;Immunoblot Analysis;in vivo;indexing;Kidney;Kidney Diseases;knock-down;Knockout Mice;Laboratories;Length;light microscopy;LoxP-flanked allele;Magnetic Resonance Imaging;Malignant Neoplasms;Measures;Mendelian disorder;Messenger RNA;MicroRNAs;Minnesota;Modeling;Molecular Analysis;mouse model;mRNA Expression;Mus;mutant;Mutant Strains Mice;Mutation;nephrogenesis;Nephrons;new therapeutic target;Nucleotides;Oncogenic;Open Reading Frames;Organ Culture Techniques;Organoids;overexpression;Partner in relationship;Pathogenicity;Pathway interactions;Patients;PKD2 gene;Polycystic Kidney Diseases;posttranscriptional;Pre-Clinical Model;prevent;promoter;protein expression;Proteins;Proto-Oncogene Proteins c-myc;PVT1 gene;Quality of life;Regulation;Renal tubule structure;RNA;Role;Safety;Serotyping;short hairpin RNA delivery;Site;small hairpin RNA;stem cells;System;Testing;Therapeutic;therapeutic candidate;therapeutic target;transcription factor;Tubular formation;Universities;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Deciphering the role of long noncoding RNA Pvt1 in preclinical models of ADPKD

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Drug Abuse (NIDA only);Genetics;Neurosciences;Substance Misuse

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the brain mechanisms that enable postural control and navigation in complex environments are disrupted in a wide variety of neurological disorders. Therefore, the proposed research is relevant to the part of the NIH’s mission to increase fundamental knowledge of the mechanisms of diseases, disorders, and dysfunctions that impair health.

PI_NAMEs: NAGEL, KATHERINE ;SCHOPPIK, DAVID  (contact);SHANER, NATHAN CHRISTOPHER;WANG, JANE

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Address;Animal Behavior;Animal Model;Animals;Behavior;Behavior monitoring;Behavioral;Bioluminescence;Biomechanics;Brain;Brain imaging;Collaborations;Complex;computer framework;Crustacea;Data;data analysis pipeline;Development;Disease;Drosophila genus;Environment;Fishes;fluorescence imaging;fly;Functional disorder;Gene Transfer Techniques;Genetic;Genetic Drift;Genetic Models;Goals;Image;Imaging Techniques;Impaired health;insight;Invertebrates;Investigation;kinematics;Knowledge;Laws;Light;limb movement;Limb structure;Locomotion;Measurement;Measures;member;Mission;model organism;Modeling;Molecular Biology;Monitor;Motor;Movement;multidisciplinary;multimodality;multisensory;Musculoskeletal Equilibrium;Nervous System Disorder;neural;neural model;neural patterning;neuroimaging;Neurons;neuroregulation;Neurosciences;new technology;next generation;non-invasive monitor;Odors;optical imaging;Organism;Physical environment;physical model;Physics;Posture;Productivity;Protocols documentation;Public Health;Reagent;Research;Resolution;Sensory;sensory feedback;sensory input;sensory stimulus;Source;statistics;Stimulus;Techniques;Technology;Testing;Time;tool;Transgenic Animals;Transgenic Organisms;United States National Institutes of Health;Vertebrates;Visual;visual stimulus;Wing;Work;Zebrafish

PROJECT_TITLE: Transformative Optical Imaging of Brain & Behavior in Navigating Genetic Species

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 SXC-N (O1)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Pediatric;Pneumonia;Pneumonia and Influenza

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE When multi-drug resistant bacteria like Klebsiella pneumoniae take up residence in the airways of ventilator- dependent pediatric patients, both the patient’s and public health are threatened. Research on how these organisms have altered the standard mechanisms of immunity in the lung by changing the metabolic environment is greatly needed to find ways to eliminate or control the detrimental effects on respiratory health. In this study, we aim to identify how lung immunity is negatively affected due to bacterial consumption of glucose, a shared energy source, so we can identify alternative strategies for bacterial eradication.

PI_NAMEs: AHN, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Acute;Address;Admission activity;Affect;Anti-Inflammatory Agents;antimicrobial;Antimicrobial Resistance;attenuation;Bacteria;Bioenergetics;Biological;Cells;Cellular Metabolic Process;Cessation of life;Child;Child Care;Clinical;Consumption;Critical Illness;Critically ill children;cytokine;Data;Deterioration;diagnostic tool;disease model;Elements;endotracheal;Energy-Generating Resources;Ensure;Environment;Enzymes;experience;experimental study;fitness;Foundations;Funding;Funding Mechanisms;Future;Glucose;glucose metabolism;Glycolysis;Goals;Health;high risk;Human;Immune;Immunity;Immunologics;Impairment;improved;In Situ;in vivo;in vivo Model;Infection;Inflammatory;inflammatory milieu;innovation;insight;Integration Host Factors;interdisciplinary approach;Intervention;Klebsiella pneumoniae;Knowledge;Literature;Lung;Mass Spectrum Analysis;Measures;Medical Care Costs;Metabolic;Metabolic Pathway;Metabolism;metabolome;Methodology;Modeling;Molecular;mortality risk;Multi-Drug Resistance;multi-drug resistant pathogen;Multiple Bacterial Drug Resistance;Mus;mutant;Myeloid Cells;Myeloid-derived suppressor cells;opportunistic pathogen;Organism;patient population;Patients;pediatric patients;Phenotype;Pneumonia;pneumonia model;Population;Population Heterogeneity;Positioning Attribute;Production;Property;Proteomics;Public Health;pulmonary function;Reactive Oxygen Species;recruit;Research;Research Design;Research Personnel;Research Project Grants;residence;resistant Klebsiella pneumoniae;respiratory colonization;Respiratory Disease;Respiratory Failure;respiratory health;response;Risk;Sampling;Severity of illness;Signal Transduction;single-cell RNA sequencing;success;Tracheostomy procedure;Tracheostomy Tube;Translating;translational impact;Ventilator;Work

PROJECT_TITLE: Host immunity in the lung is determined by the enhanced utilization of glucose by multi-drug resistant Klebsiella pneumoniae


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative Recent studies link extreme heat with adverse mental health; however more research is needed that focuses specifically on what factors increase vulnerability, and how clinical and policy interventions can better support mental health during times of extreme heat. In this mixed-methods study, we utilize data on psychiatric emergency services encounters in the Greater Boston area and interviews with the clinicians providing psychiatric care, to characterize the impacts of extreme heat among vulnerable patients in low socioeconomic status groups. Our study focuses specifically on identifying the social, behavioral, and environmental factors that influence vulnerability to adverse mental health impacts of extreme heat, with the objective of informing effective clinical and policy interventions.

PI_NAMEs: NORI-SARMA, AMRUTASRI ASHWINI (contact)

PROGRAM_OFFICER_NAME: QUINN, ASHLINN KO

PROJECT_TERMS: Acute;Affect;Age;Air Conditioning;Air Pollution;Area;Behavior;Behavioral;Big Data;Boston;built environment;Caring;Characteristics;Cities;Climate;climate change;climate impact;climate-related exposures;climate-related health;Clinical;Collaborations;Collection;Complement;cooling centers;Data;Data Collection;data resource;Data Set;design;Diurnal Rhythm;effective intervention;Emergency medical service;Emergency Situation;Environment;Environmental Risk Factor;Epidemiology;Ethnic Origin;experience;extreme heat;Future;Goals;Green space;Health;health data;health disparity;Health Personnel;heat island;Heterogeneity;high risk;high risk population;Home;Homelessness;Individual;innovation;Intervention;Interview;Investigation;Link;Literature;low socioeconomic status;Measures;Mediator;Medicaid;Medical center;Mental disorders;Mental Health;Mental Health Services;Methods;Modification;Nature;Neighborhoods;New England;Outcome;Patients;Pattern;Perception;Persons;Physicians;Play;Policies;Population;Prevention;Psychiatric Emergency Services;Psychiatric therapeutic procedure;Race;Reporting;Research;Resources;response;Risk;Role;service programs;Services;sex;social;Structure;Subgroup;Temperature;Uninsured;vulnerable community;Vulnerable Populations;Work

PROJECT_TITLE: PRIME-Boston (Prevention of and Response to Incidents of Climate-Related Mental Health Emergencies in Vulnerable Communities in Boston, MA)

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lyme Disease;Neurosciences;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is significant because the novel mouse model of Lyme neuroborreliosis (LNB) will be explored by using various neurotropic Borreliella strains. The ultimate results may be the basis for development of new therapeutics and diagnostic tools for LNB patients, which is relevant to the NIH’s mission.

PI_NAMEs: ROGOVSKY, ARTEM S (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Affect;Age;Animal Model;Animals;antimicrobial;Arthritis;behavioral study;Borrelia burgdorferi;Borrelia burgdorferi Group;Borrelia garinii;Borrelia mayonii;Brain;brain parenchyma;Carditis;Cells;Central Nervous System;Chronic;chronic infection;Clinical;Communities;Complex;Control Locus;cost;cytokine;Data;Development;diagnostic tool;Disease;Dura Mater;Encephalitis;Ethics;Exhibits;Facial nerve structure;Fatigue;flu;Foundations;Funding;Future;Genetic;Genetic Recombination;Genetic Variation;Goals;Headache;Human;Inbred C3H Mice;Infection;Inflammation;Inflammatory;innovation;insight;Interferons;Invaded;Investigation;Knowledge;Laboratory mice;Learning Disabilities;Left;Lesion;Leucocytic infiltrate;Limb structure;Lyme Disease;Lyme disease diagnosis;Lyme Neuroborreliosis;lyme pathogenesis;Maps;Memory Loss;Meningitis;Mental Depression;Mission;Modeling;mouse development;mouse model;Mouse Strains;Mus;Muscle Weakness;Nerve;neural;Neurocognitive;neuroinflammation;Neurologic;Neurologic Signs;Neurologic Symptoms;neurotropic;nonhuman primate;novel;novel diagnostics;novel therapeutics;Order Spirochaetales;Pain;Paralysed;pathogen;Pathogenesis;Pathogenicity;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;permissiveness;Phenotype;Predisposition;Process;Quantitative Trait Loci;Reagent;Research;Resolution;Resource Development;Resources;response;Sensory;sex;skin lesion;Spinal Cord;Symptoms;Testing;Tick-Borne Diseases;Tissues;tool;Treatment Protocols;Trigeminal System;United States National Institutes of Health;Up-Regulation;Vaccines

PROJECT_TITLE: A murine model of Lyme neuroborreliosis

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Tuberculosis (TB) has remained a leading global cause of death from an infectious pathogen for over a decade without the advancement of an approved novel vaccine. A slow and complex preclinical pipeline combined with a lack of biomarkers that corelate with efficacy are a challenge for the field. Here we aim to adapt a surrogate high throughput efficacy assay for use in the translational guinea pig model to help accelerate the vaccine pipeline.

PI_NAMEs: COLER, RHEA N (contact);LARSEN, SASHA E.

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: Acceleration;Address;Adopted;Animal Experimentation;Animal Model;Animals;Autologous;BCG Live;Biological Assay;Biological Markers;Blood specimen;Carbon;Cause of Death;Cavia;Cell Count;Cells;Clinical Trials;Coculture Techniques;cohort;Communities;Complex;Consumption;cost;Cryopreservation;design;Development;Disease;Dose;Drug resistance;End Point Assay;Enzyme-Linked Immunosorbent Assay;Future;Galactose;Genus Mycobacterium;Glucose;Glycolysis;Growth;guinea pig model;high reward;high risk;Housing;Human;human tissue;Immunity;Immunization;Immunize;Immunologics;Immunology;improved;in vivo;Infection;Kinetics;Mediating;Metabolism;Methodology;Methods;Modeling;Monoclonal Antibodies;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;mycobacterial;Mycobacterium tuberculosis;Neck;new technology;nonhuman primate;novel;novel vaccines;Oxidative Phosphorylation;pathogen;pathogenic bacteria;Pathologic;peripheral blood;Pilot Projects;Plasma;pre-clinical;Pre-Clinical Model;primary endpoint;Protocols documentation;Publishing;rapid testing;Reagent;Research;Resolution;Resources;response;Role;sample collection;Sampling;Serum;Source;Specificity;Standardization;System;Techniques;Technology;Time;tool;translation to humans;Tuberculosis;Tuberculosis Vaccines;Universities;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;vaccine evaluation;vaccine-induced immunity;Vaccinee;Vaccines;Work

PROJECT_TITLE: Cross development of surrogate efficacy mycobacterial growth inhibition assay endpoint for the translational guinea pig model


NIH_SPENDING_CATS: Cardiovascular;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Narrative Monocytes are cells from the immune system that are present during limb ischemia, a process that affects people with peripheral artery disease (PAD), who often require major lower limb amputation despite current treatments. Our previous study demonstrated that certain monocytes with low expression of an important enzyme in the cholesterol pathway, called 24- Dehydrocholesterol Reductase (Dchr24), can help improve blood flow and blood vessels in ischemic limbs. Our goal in this proposal is to decrease Dhcr24 expression in monocytes and understand the molecular mechanisms of this process, which we believe will lead to a unique therapeutic strategy to alleviate PAD in the near future.

PI_NAMEs: LASSANCE-SOARES, ROBERTA MARQUES (contact)

PROGRAM_OFFICER_NAME: REID, DIANE M

PROJECT_TERMS: Adoptive Transfer;Affect;Amputation;angiogenesis;Anti-Inflammatory Agents;artery occlusion;Atherosclerosis;Biology;Blood;Blood capillaries;Blood flow;blood perfusion;Blood Vessels;Bone Marrow;Bypass;Cell Proliferation;cell type;Cells;Characteristics;Cholesterol;Coculture Techniques;critical limb Ischemia;cytokine;Data;Dependence;Desmosterol;Down-Regulation;effective therapy;Endothelial Cells;Ensure;Enzymes;experimental study;Failure;femoral artery;Future;gain of function;Gangrene;Goals;Growth;Hindlimb;Hour;Human;Hypoxia;Immune system;Immunologic Memory;improved;improved outcome;Inflammation;Inflammatory;inhibitor;Interleukin-10;Interleukin-4;Ischemia;Isolated limb perfusion;Knock-in Mouse;Ligation;limb amputation;limb ischemia;Limb structure;Lower Extremity;Macrophage;Mediating;Molecular;monocyte;mouse model;Muscle;Mutant Strains Mice;Myeloid Cells;Natural Immunity;neovascularization;novel;novel therapeutic intervention;Outcome;overexpression;Oxidoreductase;Pain;Pathway interactions;Patients;Perfusion;Peripheral arterial disease;Persons;Phenotype;Play;pre-clinical;Pre-Clinical Model;Process;Proliferating;Publications;receptor;Regulation;Rest;revascularization;Role;Secondary to;single-cell RNA sequencing;Site;Smooth Muscle Myocytes;Stenosis;Testing;Therapeutic;Thrombosis;Training;transcriptomics;Transgenic Organisms;Translating;Vascular Proliferation

PROJECT_TITLE: Downregulation of 24-Dehydrocholesterol Reductase in Monocytes Improves Arteriogenesis in Peripheral Arterial Disease