NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Cities account for a large proportion of HIV prevalence and incidence, and therefore are the focus of UNAIDS' “Fast Track” approach to ending the AIDS epidemic. Several “Fast Track Cities”, including San Francisco, CA, have achieved significant reductions in new HIV infections, and yet despite this success racial/ethnic and gender disparities in new infections are emerging. The proposed study will use semi-parametric statistical modeling and HIV phylogenetics applied to routinely collected public health surveillance data, paired with primary data collection informed by a minority stress theoretical framework, to identify the residual drivers of HIV infection and offer novel targets for intervention to achieve zero new infections.

PI_NAMEs: WESSON, PAUL DOUGLAS (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acceleration;Accounting;Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Area;Black American;career;Caring;Case/Control Studies;Characteristics;Cities;Cluster Analysis;Communicable Diseases;Complex;County;Data;Data Collection;Data Sources;Diagnosis;Discrimination;disease model;Disparity;diverse data;Economics;Emerging infection;Environment;Epidemic;Epidemiologic Methods;Epidemiologic Monitoring;Epidemiology;ethnic disparity;ethnic minority;Ethnic Origin;Event;evidence base;experience;Exposure to;Female;Financial Hardship;food insecurity;Foundations;gender disparity;Goals;Harm Reduction;Health;health care availability;health care service;health disparity;Health Services;Health system;high risk population;HIV;HIV Antibodies;HIV diagnosis;HIV Infections;housing instability;improved;Incidence;Individual;Inequality;Inequity;Infection;infection rate;infection risk;innovation;insight;Interruption;Intervention;Knowledge;Laboratories;Link;Machine Learning;marginalized population;Matched Case-Control Study;Measures;Mediation;Medical;Methodology;Methods;Minority Groups;minority stress;Modeling;Molecular;Molecular Epidemiology;multidisciplinary;Needle Sharing;Needle-Exchange Programs;novel;Pathway interactions;Persons;Phylogenetic Analysis;Population;Population Heterogeneity;Population Sizes;Population Surveillance;Populations at Risk;Positioning Attribute;pre-exposure prophylaxis;Prevalence;prevention service;Public Health;Race;racial disparity;racial minority;racial minority population;Reporting;Reproducibility;Research;Research Design;Research Personnel;Residual state;Resources;response;Risk;Risk Factors;San Francisco;scale up;Science;semiparametric;sex;sexual minority group;Signal Transduction;Site;social;Social Behavior;Social Environment;social epidemiology;social factors;social stigma;social structure;sociodemographics;Source;Statistical Methods;Statistical Models;structural determinants;success;surveillance data;System;Techniques;Testing;testing services;theories;tool;Training;Training Programs;transmission process;United States;Universal Coverage;Viral;Viral Load result;Vulnerable Populations;Woman;Work

PROJECT_TITLE: The science for the last mile: Enhanced epidemiologic surveillance to accelerate HIV elimination


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Networking and Information Technology R&D (NITRD)

ORG_CITY: BROOKLYN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative Experimentation protocols are not always capable of deeply probing the mechanisms of complex biological systems. We have developed a free, customizable, open-source software system, known as Real-Time eXperiment Interface (RTXI), that enables experimentalists to perform reproducible innovative protocols that are adapted on-the-fly to optimize information acquisition and experiment control during the course of an experiment. This project, which aims to expand the functionality of RTXI in multiple critical ways, will further the abilities of biological scientists to use such protocols to investigate important questions for biological systems ranging from the heart to the brain.

PI_NAMEs: CHRISTINI, DAVID J. (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Address;Adoption;analog;Area;Auditory;Back;base;Benchmarking;Biological;biological systems;Brain;Closure by clamp;Code;Communities;complex biological systems;Computer software;Computers;cost;Data;density;Development;Devices;digital;Electrodes;Electroencephalography;Ensure;experience;experimental study;falls;Feedback;Foundations;Future;graphical user interface;Heart;innovation;instrument;Ion Channel;Laboratories;Letters;Libraries;Linux;Measurement;Modality;Modeling;Modification;Monitor;Neurons;neuroregulation;open source;Operating System;Optics;Output;Performance;programs;Protocols documentation;Pythons;Real-Time Systems;Reporting;Reproducibility;Research;Research Personnel;Science;Scientist;Sleep;software repository;software systems;Stimulus;System;Systems Integration;Technology;Time;tool;United States National Institutes of Health;Update;usability;Validation;web site;Work

PROJECT_TITLE: Real-Time eXperiment Interface - Enabling closed-loop biological experiment control

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative (Public Health Relevance): We will determine patients’ attitudes and beliefs about biologics, provider motivators for prescribing biologics, and establish the real-world comparative effectiveness of biologic therapies in minority patients with asthma. These could lead to interventions to improve asthma outcomes in minority patients.

PI_NAMEs: AKENROYE, AYOBAMI T (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: Adherence;Adrenal Cortex Hormones;African American population;Asthma;Attention;Attitude;Award;Belief;Big Data;Biological;Biological Products;Biological Response Modifier Therapy;Black Populations;Career Transition Award;Caring;Cessation of life;Characteristics;cohort;comparative effectiveness;Complex;cost;Data;data warehouse;Databases;design;Disparity;disparity elimination;disparity reduction;drug efficacy;Effectiveness;Emergency department visit;Enrollment;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;Focus Groups;Goals;Heterogeneity;Hispanic Populations;Hospitalization;IgE;IL4R gene;IL5 gene;improved;Inhalation;Injectable;Insurance;Interleukin-5;Interleukins;Intervention;Interview;Laboratories;Mediation;Medicare;Methods;Minority;Minority Groups;minority patient;Modeling;Modification;Morbidity - disease rate;mortality;Motivation;Outcome;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Pharmacoepidemiology;pharmacologic;Phase;Population;Population Heterogeneity;Postdoctoral Fellow;Prospective cohort;Provider;provider factors;public health relevance;Puerto Rican;Qualitative Methods;Quality of life;Race;racial difference;racial minority;racial population;randomized trial;Randomized, Controlled Trials;Reporting;Research;Research Personnel;response;Route;Source;Time;Training;treatment and outcome;treatment effect

PROJECT_TITLE: Synthesizing Trial and Real-world Data on the Use of Biologics in Patients with Severe Asthma


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biotechnology;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Genetics;Obesity;Pediatric;Precision Medicine;Prevention

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

ORG_STATE: WA

PHR: Narrative Despite treatment, a significant proportion of patients with type 2 diabetes (T2D) do not see clinical improvement (i.e., lack treatment response), but we know little about contributing factors and lack tools to prospectively identify likely treatment responders and non-responders. Circulating microRNAs may reflect or predict treatment response at the level of the beta cell and can serve as candidate biomarkers of treatment response. Biomarkers of treatment heterogeneity will help to prospectively identify likely treatment responders and will facilitate development of precision medicine interventions to prevent or delay the progression of T2D.

PI_NAMEs: JANUSZEWSKI, PANDORA LUKE (contact);ZRAIKA, SAKENEH

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Address;Adult;Aftercare;Age;age related;aged;Apoptosis;bariatric surgery;BCL2 gene;Beta Cell;Bioinformatics;Biological Assay;Biological Markers;biomarker panel;Body mass index;candidate marker;case control;Categories;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Childhood;circulating biomarkers;circulating microRNA;Circulation;Clinical;Closure by clamp;Data;Data Analyses;design;Development;Diabetes Mellitus;epigenetic regulation;exosome;experimental study;Exposure to;Fasting;gain of function;Gene Expression Regulation;Genes;glargine;Glucose;Goals;Heterogeneity;Human;Hyperglycemia;improved;In Vitro;in vitro Model;indexing;Insulin;insulin secretion;insulin sensitivity;Intervention;islet;islet amyloid polypeptide;Islets of Langerhans;Knowledge;liraglutide;locked nucleic acid;malignant stomach neoplasm;Measurement;Measures;Mediating;Medical;member;Metabolism;Metformin;MicroRNAs;Nested Case-Control Study;next generation;next generation sequencing;Non-Insulin-Dependent Diabetes Mellitus;novel;Operative Surgical Procedures;Organ;Participant;Pathway Analysis;Patients;Pattern;Pharmaceutical Preparations;Pilot Projects;Placebo Control;Placebos;Plasma;precision medicine;Prediabetes syndrome;Prediction of Response to Therapy;predictive marker;predictive panel;preservation;prevent;prospective;Randomized;Randomized, Controlled Trials;responders and non-responders;response;Role;Sampling;sex;standard measure;Subgroup;Testing;Tissues;tool;transcriptome sequencing;transcriptomics;treatment responders;treatment response;Untranslated RNA;Youth

PROJECT_TITLE: Circulating miRNAs and prediction of beta-cell treatment response: The Restoring Insulin Secretion Study

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: DAYTON

ORG_NAME: WRIGHT STATE UNIVERSITY

ORG_STATE: OH

PHR: Narrative: Our work is identifying novel electrical currents responsible for the muscle dysfunction in diseases of electrical signaling. If successful, our studies will result in the development of novel therapies for patients with a number different skeletal muscle diseases.

PI_NAMEs: RICH, MARK M (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Action Potentials;Attention;Chloride Channels;Closure by clamp;Contracts;Data;Dependence;Development;Disease;Drops;drug testing;Drug usage;effective therapy;efficacy testing;Electrophysiology (science);Event;Exercise;extracellular;Functional disorder;gain of function mutation;Generations;Genetic;Goals;Health;Hour;hyperkalemia;Hyperkalemic periodic paralysis;improved;In Vitro;in vivo;Inherited;Ion Channel;Ions;Knock-out;Knockout Mice;loss of function mutation;Measurement;Measures;Modification;Molecular;motor disorder;motor function improvement;motor symptom;Movement;Mus;Muscle;Muscle function;muscle stiffness;Muscle Weakness;Muscular Atrophy;Myopathy;Myotonia;Myotonia Congenita;Neurons;novel;novel strategies;novel therapeutics;Patients;Percussion;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacotherapy;Play;Potassium Channel;prevent;Property;response;Role;Signal Transduction;Skeletal Muscle;Sodium Channel;Stretching;Symptoms;System;Testing;TRP channel;United States National Institutes of Health;voltage;voltage clamp;Work

PROJECT_TITLE: Novel Approaches to Therapy of Muscle Ion Channelopathies

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative Using inexpensive CT exams that are suitable for screening, we will analyze fat around the coronary arteries, a tissue which has been implicated in biological studies of atherosclerosis. We will determine if artificial intelli- gence analysis of the fat can predict future cardiovascular events (e.g., heart attack). With success, this re- search could lead to improved detection of disease and management of patients, improving cardiovascular health.

PI_NAMEs: RAJAGOPALAN, SANJAY ;WILSON, DAVID LYNN (contact)

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: Adipose tissue;Advocate;Agatston Score;Angiography;Appearance;Archives;Arterial Fatty Streak;Arteries;Artificial Intelligence;Atherosclerosis;attenuation;Big Data;Biological;Biology;Biomedical Engineering;Blood flow;calcification;Calcium;Cardiac;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cause of Death;Cells;Clinical;cohort;comorbidity;contrast enhanced computed tomography;Coronary;Coronary Arteriosclerosis;Coronary artery;Coronary Artery Risk Development in Young Adults Study;cost;deep learning;Detection;Diabetes Mellitus;Disease;diverse data;Early Diagnosis;Engineering;Ensure;Event;evidence base;experimental study;Fatty acid glycerol esters;Future;Gender;Genes;Goals;Health;health disparity;high risk;Image;image processing;improved;indexing;Individual;Inflammation;Inflammatory;Infusion procedures;Institution;Iodine;Knowledge;Location;Machine Learning;Measures;Medicine;meetings;Methods;Modeling;mortality;multiple datasets;Myocardial Infarction;Oncology;Pathway interactions;Patients;Perfusion;personalized medicine;Phenotype;Physicians;programs;Psoriasis;Race;radiomics;Reproducibility;Research;research study;Risk;Risk Factors;risk prediction;Role;Scanning;Scientist;screening;Services;Severities;Site;success;Texture;theories;Time;Tissues;tool;University Hospitals;Validation;vasa vasorum;Vascular Diseases;X-Ray Computed Tomography

PROJECT_TITLE: Pericoronary fat: MACE risk from non-contrast CT and the role of iodine perfusion in contrast CT

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Dissemination and Implementation Research;Emergency Care;Emerging Infectious Diseases;Health Services;Infectious Diseases

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: PROJECT NARRATIVE In the context of the largest pandemic in a century, emergency department staff have been called to provide care for a previously unknown disease and therefore have been rapidly innovating to deliver effective care, protect frontline workers, and ensure a sustainable supply of personal protective equipment, with little known about which of these innovations are safe or effective. This project will explore how emergency department staff learn about emerging innovations and make decisions about implementation and de-implementation in a crisis. Through interviews, surveys, and focus groups with clinicians such as physicians, nurses, and respiratory therapists; practice leaders; and information disseminators in emergency medicine, in coordination with organizations representing the field, we will analyze the dissemination and implementation of innovations in care for COVID-19 and identify strategies and lessons learned for optimizing the diffusion of care innovations during COVID-19 that could be relevant for other rapidly evolving pandemics and public health emergencies.

PI_NAMEs: FISCHER, SHIRA HANNAH;MENDEL, PETER JAMES (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 2019-nCoV;Access to Information;Accident and Emergency department;Adoption;Azithromycin;Beds;Caring;Cessation of life;Combined Modality Therapy;Communication;Communities;COVID-19;COVID-19 pandemic;COVID-19 patient;Critical Care;Critical Illness;Dangerousness;Decision Making;Deimplementation;demographics;Diffusion;Diffusion of Innovation;Discipline;Discourse analysis;Disease;Dissemination and Implementation;Drug Prescriptions;Educational workshop;Emergency Care;Emergency Department Physician;Emergency Medicine;Emergency Nursing;Emergency Situation;Ensure;Environment;Evaluation;Explosion;Facebook;Focus Groups;Fright;Frontline worker;Future;Government;Health;Health Policy;Healthcare;Healthcare Systems;Hospitals;Hydroxychloroquine;implementation science;implementation strategy;improved;improved outcome;Infection;Information Dissemination;innovation;insight;Intensive Care Units;Intervention;Interview;Journals;Learning;Long-Term Care;Methods;Misinformation;Natural Language Processing;Nurses;pandemic disease;Patient-Focused Outcomes;Patients;personal protective equipment;Persons;Physicians;podcast;Population;prevent;Printing;Process;Professional Organizations;public health emergency;Publications;Recommendation;Research;Resources;respiratory;response;Role;Services;social media;Source;Stress Tests;Surveys;System;Techniques;Technology;Time;Twitter;Ventilator;Work

PROJECT_TITLE: Dissemination and Implementation of COVID-19 Care Innovations in ED Settings

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Problems with negative emotion and social behavior are present across many behavioral health conditions, but are poorly measured with existing tools. This application addresses this problem by developing and validating novel facial expression and linguistic measures that can be easily and widely disseminated across research and clinical settings.

PI_NAMEs: HERRINGTON, JOHN DAVID (contact);STORCH, ERIC A.

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Acceleration;Achievement;Address;Adolescence;Adolescent;affective computing;Age;aged;Anxiety;Anxiety Disorders;autism spectrum disorder;autistic children;Behavior;Behavior assessment;behavior measurement;behavioral health;Behavioral Sciences;biobehavior;Child;Child Development;Clinical;clinical phenotype;Clinical Research;Clinical Sciences;college;Computational Linguistics;Computer Vision Systems;Computers;cost;Data;Data Collection;Depressive disorder;Development;Diagnosis;Diagnostic;digital phenotyping;Dimensions;Elements;Emotional;emotional behavior;emotional functioning;Emotions;Ethnic Origin;experimental study;Face;Facial Expression;Factor Analysis;Frustration;Funding;Gender;Goals;Grain;Hour;Human;indexing;Individual;Individual Differences;individual variation;Intervention;Interview;Investments;Judgment;Laboratories;Linguistics;Machine Learning;Maps;Measurement;Measures;Medicine;Mental Depression;Mental Health;Methodology;Methods;Modeling;Mood Disorders;Moods;Multivariate Analysis;National Institute of Mental Health;natural language;Negative Valence;NIH Program Announcements;non-verbal;novel;Parents;Participant;Pediatric Hospitals;Philadelphia;Play;Population;Predictive Analytics;Procedures;programs;Psychiatric Diagnosis;Psychopathology;Quality of life;Race;repetitive behavior;Reporting;Research;Research Domain Criteria;Research Personnel;Resources;response;Sampling;showing emotion;Signal Transduction;Site;Smiling;social;social anxiety;Social Behavior;social deficits;social metrics;Social Processes;social stress;Specialist;System;Testing;Thinness;Time;tool;Training;Translating;Trier Social Stress Test;Variant;verbal;Youth

PROJECT_TITLE: Optimized Affective Computing Measures of Social Processes and Negative Valence in Youth Psychopathology

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW YORK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  Microsporidia are unicellular,  fungal  parasites with a wide host-range, from insects to humans;  they are emerging pathogens, classified as NIAID Category B opportunistic pathogens, and cause microsporidiosis in immunocompromised patients.  To gain entry into a target cell, microsporidia employ a remarkably unique and specialized harpoon-like invasion machine called the polar tube, which is conserved among microsporidial species. Here we will focus on understanding the mechanism by which microsporidial parasites use this unique organelle to initiate infection, which may provide broader insights into infection mechanisms used by other eukaryotic parasites.

PI_NAMEs: BHABHA, GIRA  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Address;Animals;Architecture;Biochemical;Biochemistry;Biological Assay;Biology;Biophysics;Bombyx;burden of illness;Categories;Cells;Cellular biology;Cilia;Classification;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Data;Disease;electron tomography;emerging pathogen;Encephalitozoon cuniculi;Encephalitozoon hellem;Environment;experimental study;Face;Farm;Fishes;Fluorescent Dyes;Freezing;genetic manipulation;Growth;Human;human pathogen;Image;Immunocompromised Host;In Situ;In Vitro;in vivo;Individual;Infection;Insecta;insight;Invaded;Ions;Light;light microscopy;lightspeed;Mass Spectrum Analysis;Microscopy;Microsporidia;Microsporidiosis;Microtubules;Modernization;Molecular;Molecular Conformation;mortality;Movement;Names;National Institute of Allergy and Infectious Disease;opportunistic pathogen;Optics;organ transplant recipient;Organelles;Parasites;particle;pathogen;Patients;Process;protein complex;protein protein interaction;protein purification;Protein Subunits;Proteins;Proteome;reconstruction;Reproduction spores;Resolution;Sampling;Scanning Electron Microscopy;Sequence Homology;Side;Speed;structural biology;Structure;Techniques;Thinness;Tube;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural basis of the polar tube invasion machinery from microsporidia parasites

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: FARMINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative Globoid cell leukodystrophy (GLD) is an incurable genetic disease of the central nervous system that is recognized by profound white matter loss (demyelination), neurodegeneration and inflammation. Using genetic profiling technology, we have determined that this disease is distinguished from healthy, non-disease nervous tissues by a prominent CD8 T cell population which has an untested contribution to this disease. Based on our strong preliminary data which demonstrate that blocking these T cells we can effectively prevent disease, this project will interrogate the role of CD8 T cells, by applying advanced genetic tools including transgenic animals and unbiased RNA sequencing approaches, to determine how these adaptive immune cells with strong pathogenic potential are involved in GLD.

PI_NAMEs: CROCKER, STEPHEN J (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: 5 year old;adaptive immunity;Address;Affect;Antibodies;Antigen-Presenting Cells;Antigens;Automobile Driving;Behavioral;Biochemical;Blood;Body Weight decreased;Brain;brain tissue;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Therapy;cell type;Cells;Cellular Immunity;Central Nervous System;central nervous system demyelinating disorder;Central Nervous System Diseases;Cessation of life;Child;Clinical;Cognitive deficits;Complex;cytokine;Cytometry;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Data;defined contribution;Demyelinations;Development;Disease;Effectiveness;Flow Cytometry;Future;galactosylceramidase;gene therapy;Genes;Genetic;genetic approach;Genetic Diseases;genetic profiling;Globoid cell leukodystrophy;Histologic;Human;Image;Immune;Immunity;improved;Inflammation;Inflammatory;insight;Investigational Therapies;Knockout Mice;Knowledge;Lesion;Life Expectancy;life span;Lipids;Live Birth;Location;Longevity;loss of function;loss of function mutation;Maps;Mediating;Meningeal;Modeling;Molecular;Motor disability;mouse model;multidisciplinary;Mus;Mutation;Nature;Nerve Degeneration;Nerve Tissue;neuroinflammation;neuropathology;Nonsense Codon;novel;Oligodendroglia;Onset of illness;Outcome;Outcome Measure;Outcome Study;Paralysed;Pathogenesis;Pathogenicity;Pathologic;Pathology;pharmacologic;Phenotype;Play;Population;postnatal;preservation;prevent;Process;Psychosine;Reporter Genes;response;Role;single-cell RNA sequencing;spatial relationship;success;T cell clonality;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;tool;transcriptome sequencing;transcriptomics;Transgenic Animals;Transgenic Organisms;white matter

PROJECT_TITLE: Role of CD8 T cell-mediated Pathology in Globoid Cell Leukodystrophy

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Prevention;Primary Health Care;Social Determinants of Health

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Findings from this study will provide low health literate older adult populations the capability to improve their care and quality of life and consequently be scalable and applicable to educate patients where other health conditions require informed decisions.

PI_NAMEs: CADET, TAMARA J. (contact)

PROGRAM_OFFICER_NAME: RADZISZEWSKA, BARBARA

PROJECT_TERMS: Adult;Affordable Care Act;Area;Attention;Award;Behavior;Belief;Benefits and Risks;Boston;cancer diagnosis;career;career development;Caring;Cessation of life;Cognitive;Collaborations;colon cancer screening;Colorectal Cancer;colorectal cancer screening;Communities;community organizations;Consultations;Data;Decision Aid;design;Development;Economics;Education;Educational Status;Elements;eligible participant;Ensure;Environment;ethnic minority status;Ethnic Origin;evidence base;expectation;experience;Family member;Feedback;Focus Groups;Funding;Goals;group intervention;Guidelines;Health;health communication;Health Educators;health literacy;Health Promotion;Health Services;improved;Individual;Institution;Intervention;Interview;Israel;Knowledge;Learning;Life Expectancy;literate;low health literacy;low socioeconomic status;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Mammography;Measures;Medical center;Medicine;Mentors;Methodology;Methods;Neighborhood Health Center;novel;older adult;Pamphlets;Paper;Participant;Patient Participation;Patient-Focused Outcomes;Patients;Perception;personalized decision;Policies;Population;preference;prevent;Primary Care;Probability;Process;Psychology;Quality of Care;Quality of life;Race;racial minority;Randomized, Controlled Trials;Reading;Recommendation;recruit;Research;research and development;Research Personnel;Resources;Risk;Risk Factors;Schools;Science;screening;secondary outcome;Secure;Self Efficacy;seventh grade;Sex Differences;shared decision making;Site;skills;Social Work;Structure;success;Testing;theories;Time;tool;Training;United States National Institutes of Health;Universities;uptake;Woman;Writing

PROJECT_TITLE: Shared decision-making and colorectal cancer screening behaviors among older adults with low health literacy

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Epilepsy;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Human infection with the widely transmissible parasite, Toxoplasma gondii, has surfaced as a major risk factor for developing psychiatric illness and neurological disorders, such as seizures. This project aims to reveal im- portant information on the dynamic neuroimmune mechanisms by which long-term parasitic infection alters neu- ral circuits in the brain – a critical step to creating preventative and therapeutic treatments in aid of these complex disorders.

PI_NAMEs: CARRILLO, GABRIELA LIZANA (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acute;Address;Adult;American;Behavioral;Biology;Brain;brain circuitry;Cause of Death;Cells;Cessation of life;Chronic;chronic infection;Chronic Phase;Clinical;Communicable Diseases;Complement;Complement 1q;complement pathway;Complex;Development;Disease;Electroencephalography;Ensure;Environment;Excitatory Synapse;experimental study;Face;Faculty;Fetal Development;foodborne illness;Genetic;glial activation;Goals;Health;Human;Human body;Image;imaging modality;Immune response;Immunocompromised Host;Individual;Infection;Infectious Diseases Research;Inflammation;Inflammatory Response;Infrastructure;Inhibitory Synapse;Innate Immune System;insight;Institution;interdisciplinary collaboration;Interdisciplinary Study;Knowledge;Label;Life;Macrophage;Mediating;Mental disorders;Mentors;Microglia;Mission;Molecular;molecular array;Motor Neurons;Mus;Nerve;Nervous System Disorder;neural;neural circuit;Neuroglia;Neuroimmune;neuroimmunology;Neuroimmunomodulation;Neurologic;Neuronal Injury;Neurons;Neurosciences;neurotransmission;novel;novel therapeutics;Organ;parasite invasion;Parasites;Parasitic infection;pathogen;Pathogenesis;Pathway interactions;Phagocytosis;Pharmaceutical Preparations;Phase;Population;Populations at Risk;Postdoctoral Fellow;pre-clinical;Predisposition;presynaptic;Prevalence;prevent;programs;Proteins;Publishing;Recording of previous events;Records;Reporting;Research;Research Project Grants;Residencies;response;Retina;Risk;Risk Factors;Role;Schizophrenia;Seizures;Skeletal Muscle;success;Surface;Synapses;tenure track;Testing;Therapeutic;Time;tool;Toxoplasma gondii;Toxoplasmosis;Training;Transgenic Organisms;Translating;Tropism;two-photon;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Development of Facial Motor Neuron Subtypes in Health and in Congenital Facial Weakness


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Lymphatic Research;Orphan Drug;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE: Corneal neovascularization (CoNV) is a sight-threatening condition affecting more than 1.4 million people per year. The objective of this proposal is to investigate the role of Angiopoietin- like 4/Neuropilins, alone or in combination with VEGFs, as regulators of hemangiogenesis and lymphangiogenesis in CoNV. The ultimate goal of our investigations is to design better therapeutic modalities for the prevention and treatment of this blinding disease.

PI_NAMEs: SODHI, AKRIT SINGH (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Affect;Affinity;alternative treatment;angiogenesis;Angiogenesis Inhibitors;Angiogenic Factor;ANGPTL4 gene;antagonist;Anterior;bevacizumab;Binding;Blindness;Blood Vessels;Cell membrane;cell motility;Cicatrix;combinatorial;Combined Modality Therapy;Conjunctival Pterygium;Cornea;Corneal Neovascularization;Corneal Opacity;Corneal Stroma;Data;Deposition;design;Development;Diabetic Retinopathy;Disease;Edema;effective therapy;Engineering;Etiology;Eye;Family;Goals;Growth;In Vitro;in vivo;Inflammation;insight;Investigation;KDR gene;Limbus Corneae;Lipids;Lymphangiogenesis;lymphatic development;Lymphatic Endothelial Cells;lymphatic vessel;Mediator;Medical;member;migration;Modality;Molecular;mutant;neovascular;Neuropilin-1;Neuropilin-2;Neuropilins;novel;novel therapeutics;NRP1 gene;Optics;Pathogenesis;Pathologic;Pathologic Neovascularization;Pathway interactions;Patients;Persons;Play;Prevention;Process;Protein Isoforms;Proteins;receptor;Regimen;Reporting;Retina;Retinal Diseases;Role;sickling;Signal Transduction;Structure;synergism;targeted treatment;Technology;Therapeutic;Tissues;Uveal Melanoma;Vascular Diseases;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;VEGFA gene;VEGFC gene;Vision;Visual impairment

PROJECT_TITLE: Molecular Engineering of Novel Therapies to Treat Corneal Neovascularization

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative We are examining the early steps in the lifecycle of flaviviruses, including identification of cellular factors required for viral replication. Flaviviruses represent major threats to public health; understanding their lifecycle will facilitate the design of new or improved therapies and vaccines.

PI_NAMEs: UCHIL, PRADEEP D (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Ablation;Address;Anti-viral Agents;Anti-viral Therapy;arthropod-borne;ATP phosphohydrolase;Capsid Proteins;Cells;chemical genetics;combinatorial;Culicidae;Data;Dengue Virus;design;Development;Environment;Enzymes;Event;Family;Flavivirus;Future;Gene Expression;Genetic;genetic approach;Genome;Health;Human;human disease;improved;invertebrate host;Life Cycle Stages;Link;Macromolecular Complexes;member;Modeling;Molecular;Monitor;Multiprotein Complexes;mutant;Nucleocapsid;Peptide Hydrolases;Play;Polyproteins;Process;Protein Family;Proteins;prototype;Public Health;Reporter;rhomboid;RNA replication;Role;Serine Protease;Techniques;tool;Translating;Translations;Vaccines;valosin-containing protein;Viral;Viral Genes;Viral Genome;Viral Proteins;Virion;virus host interaction;Virus Replication;West Nile virus;Yellow fever virus;Zika Virus

PROJECT_TITLE: Essential early events in the flavivirus lifecycle

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-W(02)M]


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Signaling through the bacterial second messenger c-di-GMP is subject to exquisite control, especially in bacterial pathogens, which often simultaneously express a multitude of signaling components for setting cellular and local c-di-GMP levels and triggering distinct physiological responses, for example, controlling the expression of multiple adhesins critical for establishing a biofilm. The proposed studies will elucidate both intra- and inter-molecular modes of regulation of bacterial c-di-GMP signaling, explore the role for adhesins and their sub-domains in biofilm formation, and extend our work to a new and unusual Lap-like system in a human-associated microbe.

PI_NAMEs: O'TOOLE, GEORGE A. (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Adhesions;analog;Architecture;Bacteria;Bacterial Adhesins;Bacterial Genome;Binding;Biochemical;Bioinformatics;Cell Adhesion;Cell surface;chronic infection;Citrates;Communicable Diseases;Complex;Conserved Sequence;Cytoplasm;Desulfovibrio vulgaris;Development;diguanylate cyclase;Dinucleoside Phosphates;extracellular;Family;Family member;Genetic;gut microbes;Homologous Gene;host-microbe interactions;Human;insight;Intestines;Life Style;Ligand Binding;Ligand Binding Domain;Ligands;Link;Mediating;Membrane;Microbe;Microbial Biofilms;microbial community;Molecular;novel;novel therapeutics;Organism;Output;pathogenic bacteria;pathogenic microbe;Pathogenicity;Peptide Hydrolases;Periodicity;periplasm;Phylogenetic Analysis;Physiological;polymicrobial biofilm;Polysaccharides;posttranscriptional;preventive intervention;Process;Production;Proteins;Pseudomonas fluorescens;receptor;reconstitution;Regulation;Reporting;response;Role;Second Messenger Systems;Signal Transduction;small molecule;Structure;sugar;sulfate reducing bacteria;Surface;Swimming;System;Testing;tool;Variant;Work

PROJECT_TITLE: cdG Signaling and Adhesion Deployment During Biofilm Initiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIA-W(80)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

ORG_CITY: DAVIS

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: The objective of this application is to define the role and molecular mechanisms underlying disturbed myelin formation in hypoxia/ischemia-induced white matter injury. Our project is relevant to and has implications for public health because it will likely provide new insights into therapeutic interventions diminishing the myelin deficits clinically observed in the brain of preterm infants affected by diffuse white matter injury.

PI_NAMEs: GUO, FUZHENG  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;Animal Model;Animals;Astrocytes;autocrine;beta catenin;Biology;Birth;Brain;Brain Hypoxia-Ischemia;Cells;Central Nervous System;Clinical;Clinical Research;Communication;Data;design;Development;Diffuse;Diffuse Axonal Injury;Diffusion;effective therapy;Environment;Exposure to;Felis catus;Future;Genetic;Gestational Age;glial activation;glial cell development;Goals;HIF1A gene;Human;Hypoxia;Hypoxia Inducible Factor;Impairment;In Vitro;in vivo;Infant;innovation;insight;ischemic injury;Knowledge;Lesion;Mediating;Mediator;Molecular;motor deficit;mouse model;Mus;mutant;Myelin;myelination;Nature;neurodevelopment;Neuroglia;novel;oligodendrocyte progenitor;Oligodendroglia;paracrine;Pathologic;Pathology;Pathway interactions;Periventricular Leukomalacia;Physiological;Pregnancy;premature;Premature Birth;Premature Infant;Public Health;Regulation;Reporting;Respiratory System;Role;Seminal;stem cell differentiation;stem cells;Survivors;System;Testing;Textbooks;Therapeutic;Therapeutic Intervention;Time;tool;United States;Virulence Factors;Visit;white matter;white matter injury;WNT Signaling Pathway

PROJECT_TITLE: Glial HIFa: mechanisms and implications in hypoxia/ischemia-induced oligodendroglial pathology

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Burden of Illness;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will identify the principal zoonotic sources of human campylobacteriosis and highly drug resistant Campylobacter infection in a low income country where genomic epidemiology has not yet informed our understanding of disease transmission. This information is critical to the design targeted efficient disease control measures where multiple possible sources of infection co-exist and there is an array of possible disease control strategies. It is relevant to the NIH’s mission to control and prevent infectious diseases that affect humans.

PI_NAMEs: KOSEK, MARGARET N (contact);PARKER, CRAIG THOMAS

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: Affect;Animals;antimicrobial;Antimicrobial Resistance;Area;Azithromycin;Bacteriophages;Bioinformatics;burden of illness;Campylobacter;Campylobacter coli;Campylobacter infection;Campylobacter jejuni;Chickens;Childhood;Communicable Diseases;Country;Data;Databases;design;Development;Disease;disease transmission;disorder control;Domestic Animals;Domestic Fowls;Drug-resistant Campylobacter;Ecology;effective intervention;Enteral;enteric infection;enteric pathogen;Enteritis;Epidemiology;Etiology;Europe;evidence base;Family suidae;fluoroquinolone resistance;Fluoroquinolones;foodborne illness;France;Future;Genetic;Genome;Genomic approach;genomic data;genomic epidemiology;Genomics;Geography;Goals;Guillain Barré Syndrome;Health;Household;Human;human disease;improved;Incidence;Income;Industrialization;Infection;innovation;International;Intervention;Investments;Irritable Bowel Syndrome;Knowledge;Link;Livestock;low and middle-income countries;low income country;Malnutrition;Measures;Meat;Meat Products;Methodology;microbial;microbial genomics;Microbiology;Mission;Modernization;Morbidity - disease rate;Multicenter Studies;New Zealand;Oral;Outcome;pathogen;Persons;Peru;Policies;Population;prevent;Production;programs;Public Health;reference genome;Research;Research Personnel;Resistance;resistant strain;Resolution;Risk;Risk Factors;Ruminants;segregation;Source;successful intervention;Syndrome;Testing;transmission process;Travel;United States;United States National Institutes of Health;Work;Zoonoses

PROJECT_TITLE: Genomic Epidemiology of Campylobacter to Improve Disease Control in Low and Middle Income Countries

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Liver Disease;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: PHOENIX

ORG_NAME: TRANSLATIONAL GENOMICS RESEARCH INST

ORG_STATE: AZ

PHR: NARRATIVE Children with fatty liver are at higher risk for poor long-term health outcomes and early death in adulthood. This study will identify molecular factors associated with fatty liver in children with obesity, determine what happens to these factors following interventions resulting in decreased liver fat, and characterize mechanisms by which these factors contribute to fatty liver. Results from this work will lead to an improved understanding of how fatty liver develops in children and may identify new diagnostic and therapeutic targets for this health condition.

PI_NAMEs: DISTEFANO, JOHANNA K (contact);SHAIBI, GABRIEL QUANTUM

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: accurate diagnosis;Address;Adolescent;Adult;Affinity;Age;Apoptosis;bariatric surgery;Biological;Biopsy;Body mass index;burden of illness;Cardiovascular Diseases;Caring;Cell Communication;cell type;Cells;Cellular biology;Cessation of life;Characteristics;Child;Childhood;chronic liver disease;clinically significant;cohort;Complement;Development;Diabetes Mellitus;Diagnostic;Discriminant Analysis;Disease;Disease Marker;drug development;Economic Burden;effective therapy;experience;experimental study;extracellular vesicles;Fatty acid glycerol esters;Fatty Liver;FDA approved;Future;Gastrectomy;Health;Hepatic;Hepatic Stellate Cell;Hepatocyte;high risk;Histopathologic Grade;improved;Individual;innovation;insight;intercellular communication;Intervention;Investigation;Knowledge;Latino;Latino Population;Life;Life Style;lifestyle intervention;Lipids;Liver;liver transplantation;liver-specific protein;Macrophage;Magnetic Resonance Imaging;Measures;Mediating;Medical;Membrane;Membrane Proteins;Methods;migration;Modality;Modeling;Molecular;Morbidity - disease rate;mortality;new therapeutic target;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;novel;novel diagnostics;Nucleic Acids;Obesity;Outcome;Pathogenesis;Pathologic;Patients;Pattern;pediatric non-alcoholic fatty liver disease;Phenotype;Pilot Projects;Plasma;poor health outcome;Population;Prevalence;Prevention strategy;Primary Cell Cultures;Proliferating;Proteins;Proteomics;Receptor Activation;Research;Resolution;response;response to injury;Risk;RNA;Role;Sampling;Series;Severities;Severity of illness;sex;Shotguns;Signal Transduction;Surface;Technology;Testing;Therapeutic;tissue injury;tissue repair;Tissues;transdifferentiation;treatment strategy;vesicular release;Work;Youth

PROJECT_TITLE: Extracellular vesicle cargo and risk of NAFLD and NASH in Latino youth


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Immunization;Infectious Diseases;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Enterotoxigenic E. coli (ETEC) are one of the most common infections worldwide. ETEC cause diarrhea that can range from moderate to severe. There is no vaccine to prevent these infections. Consequently, there are hundreds of millions of cases of diarrhea among travelers, and people residing in resource limited areas.

PI_NAMEs: FLECKENSTEIN, JAMES MICHAEL (contact)

PROJECT_TERMS: 5 year old;Adjuvant;Affect;Antibodies;Antibody Formation;Antibody Response;Antigenic Diversity;Antigens;Area;B-Lymphocytes;Bacteria;Bacterial Adhesins;Bangladesh;Binding;blood group;Blood specimen;Blood typing procedure;Cells;Child;Cholera;Complex;Cryoelectron Microscopy;Data Correlations;design;Development;Diarrhea;Engineering;enterotoxigenic Escherichia coli;Enzymes;Epitope Mapping;Epitopes;Escherichia coli;Escherichia coli Infections;Escherichia coli Vaccines;feasibility testing;Genetic;Goals;Growth;Hospitalization;Human;human monoclonal antibodies;Human Volunteers;Immune;Immune response;immunogenic;Immunologic Memory;Immunologics;Immunology;Impaired cognition;In Vitro;Individual;Infection;Infection prevention;innovation;Intestines;Lectin;Link;Malnutrition;Maps;Mediating;Membrane Proteins;Memory;microbial;Microbiology;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mucins;Mucous Membrane;Mus;Nature;novel;novel vaccines;pan-genome;pathogen;Pathogenesis;Patients;Peptide Hydrolases;Persons;Plasmablast;polyclonal antibody;Predisposition;protein function;Protein Microchips;protein structure;Proteins;rational design;Recombinants;Research Personnel;Resource-limited setting;Resources;response;Sampling;Sanitation;Small Intestines;structural biology;Structure;Subunit Vaccines;Surface;Surface Antigens;T memory cell;Testing;Thermogenesis;Time;Toxin;Translating;Vaccinated;Vaccination;Vaccine Antigen;Vaccine Design;vaccine development;Vaccines;vaccinology;volunteer;Water

PROJECT_TITLE: Novel Antigen Identification for an enterotoxigenic E coli vaccine

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Patient Safety;Prevention;Wound Healing and Care

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Surgical site infection (SSI) is a major public health problem with devastating perioperative outcomes, affecting as many as 1 in 20 patients undergoing instrumented spine surgery. The development of more effective strategies for SSI prevention in spine surgery is significantly limited by a lack of fundamental understanding about the origins of causative bacteria, the basic pathogenesis of spinal wound infection, the microbiome of the back, and the role of antimicrobial resistance to surgical prophylaxis. The proposed research will use bacterial genomic methods to define these key mechanisms, including the roles of the patient microbiome, sex, and anatomy, and will be used to develop new, scientifically informed strategies for SSI prevention in spine surgery.

PI_NAMEs: LONG, DUSTIN R (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Affect;Age;Anatomy;Anesthesiology;Anterior;Antibiotic Prophylaxis;Antibiotic Therapy;Antimicrobial Resistance;Award;Back;Bacteria;bacterial genetics;Bacterial Genome;Biological;biomedical referral center;career;career development;Caring;Categories;Cefazolin;Cervical;Cessation of life;Chest;Clinical;Clinical Data;clinical risk;clinically actionable;commensal bacteria;Complex;cost;Data Set;Degenerative Disorder;Development;Development Plans;disability;Disease;Environment;Escherichia;fecal microbiome;Foundations;functional outcomes;Future;Genetic;Genetic Determinism;genome wide association study;Genomics;Goals;high risk;hospital readmission;Hospitals;improved;Individual;Infection;Infection prevention;infection rate;instrument;instrumentation;Klebsiella;Measures;Medical center;men;Mentors;Methicillin Resistance;methicillin resistant Staphylococcus aureus;Methods;Microbiology;microbiome;microbiome research;modifiable risk;Molecular;Molecular Epidemiology;molecular marker;Musculoskeletal;nasal microbiome;neoplastic;Nose;novel;Operative Surgical Procedures;Outcome;Pain;pathogen;Pathogenesis;patient population;Patients;Perioperative;Perioperative Care;personalized approach;Powder dose form;preservation;Prevention;Prevention Measures;Prevention strategy;Procedures;Prophylactic treatment;prospective;Proteus;Protocols documentation;Public Health;Registries;Repeat Surgery;Research;Research Activity;research and development;Resistance;Resistance to infection;Risk;Risk Factors;Role;Safety;Sampling;screening;sex;Skin;skin microbiome;Source;Specimen;Spinal;Spinal Fusion;Spine surgery;Staphylococcus aureus;Surgical incisions;surgical risk;Surgical Wound Infection;Techniques;tool;Training;trait;Translational Research;Trauma;Vancomycin;Vertebral column;Woman;Work;wound;Wound Infection

PROJECT_TITLE: Targeting the Patient Microbiome for the Prevention of Surgical Site Infection in Spine Surgery

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Sleep Research;Substance Misuse

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: –––– Project Narrative ––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––– Disrupted sleep is one of the most universally reported outcomes of active alcohol use and recovery from alcohol use disorder, and the harmful influence of alcohol on sleep is well-characterized but remains difficult to treat. To develop better therapies for alcohol-induced sleep effects, we must understand the genetic and molecular mechanisms underpinning the relationship between alcohol use and poor sleep. Utilizing Drosophila’s behavioral similarities with humans, many genetic tools, and high economy of scale, this work will identify genes and neural circuits regulating alcohol-induced sleep disturbances, thereby offering mechanistic targets for treating these disruptions.

PI_NAMEs: CHVILICEK, MARGARET  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: Abstinence;addiction;Affect;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol response;alcohol use disorder;Alcohols;American;Applications Grants;Area;Automobile Driving;Behavior;Behavioral;Biological Assay;Biological Models;Candidate Disease Gene;candidate identification;career;Catalogs;Characteristics;combinatorial;Communication;Darkness;Data;design;Diagnosis;Disease;Dose;drinking;Drosophila genus;Drosophila melanogaster;effective intervention;Epidemiology;Etiology;experimental study;Faculty;falls;Fellowship;fly;Foundations;Future;Genes;Genetic;genetic approach;genetic manipulation;genome wide association study;genomic locus;Goals;graduate student;Heritability;Human;human disease;Human Genome;improved;Individual;insight;knock-down;laboratory experience;Light;Link;Manuscripts;Measures;model organism;Molecular;Molecular Target;Nervous System;neural circuit;neurobiological mechanism;Neurobiology;neurogenetics;neuromechanism;neuronal circuitry;Neurons;Neurotransmitters;Orthologous Gene;Outcome;Persons;Phenotype;poor sleep;Positioning Attribute;Preparation;Public Health;Publishing;Recovery;Relapse;relapse prediction;relapse prevention;Reporting;Reproducibility;Research Personnel;Resistance;RNA Interference;Rodent;Role;Sedation procedure;Signaling Molecule;skill acquisition;skills;Sleep;sleep behavior;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep quality;sleep regulation;Sleeplessness;System;Technical Expertise;Testing;Time;tool;Training;trait;vinegar fly;Work

PROJECT_TITLE: Genetic, molecular, and neural mechanisms of alcohol-induced effects on sleep


NIH_SPENDING_CATS: Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Hydrocephalus;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Stroke;Unintentional Childhood Injury

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The research is relevant to public health because discovery of mechanisms by which intraventricular hemorrhage (IVH) contributes to cerebral palsy and hydrocephalus will lead to interventions to prevent these disorders. In the proposed study, we will evaluate lipid signaling and target their receptors to accomplish recovery in neurological function and prevent two devastating disorders--cerebral palsy and hydrocephalus--in the survivors of IVH.

PI_NAMEs: BALLABH, PRAVEEN  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adherens Junction;Adult;Affect;Agonist;antagonist;astrogliosis;Autopsy;Behavioral;Binding;Biology;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood Tests;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain Hypoxia-Ischemia;Brain Infarction;Brain Injuries;brain parenchyma;Brain region;Capillary Endothelial Cell;Cardiotoxicity;Cell Maturation;Cells;Cerebral Palsy;Cerebrum;Circulation;Cognitive deficits;Complication;contrast enhanced;Coupled;Development;Disease;effective therapy;Endothelium;Engineering;Evaluation;Event;Exudate;Failure;G-Protein-Coupled Receptors;Genetic Transcription;Glycerol;GTP-Binding Proteins;Human;Hydrocephalus;Immune;immune cell infiltrate;Immune response;Immunity;Immunosuppression;Infant;Infiltration;Inflammation;Inflammatory Response;Injury;Intervention;intraventricular hemorrhage;Leucocytic infiltrate;Leukocytes;Lipid A;lipid mediator;Lipids;Liquid substance;Magnetic Resonance Imaging;Mediating;Microglia;migration;Modeling;Molecular Chaperones;Morphology;Multiple Sclerosis;Mus;myelination;Myeloid Cells;neonate;Nervous System Physiology;Nervous System Trauma;neurobehavior;neurobehavioral;Neurologic;neuroprotection;novel;novel therapeutics;Obstruction;oligodendrocyte progenitor;Oryctolagus cuniculus;Pathologic;Pathway interactions;Permeability;Pharmaceutical Preparations;premature;Premature Infant;prevent;Production;Public Health;receptor;Receptor Signaling;Recovery;Research;restoration;rho;Role;Sampling;SHH gene;Signal Transduction;single cell mRNA sequencing;small hairpin RNA;smoothened signaling pathway;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;stem cells;Stroke;Structure of choroid plexus;Survivors;targeted treatment;Testing;Tight Junctions;Time Study;Tracer;trafficking;transcriptome;transcytosis;Ventricular;white matter;white matter injury

PROJECT_TITLE: Intraventricular Hemorrhage Disrupts the Blood Brain Barrier in Premature Infants

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PSC is a complex cholestatic liver disease with limited treatment options and dismal prognosis and biliary senescence induces mast cell (MC) migration which promotes PSC progression, in vivo. IL-33/ST2 signaling is upregulated in cholestatic injury and induces MC migration/activation. Melatonin therapy decreases PSC phenotypes and inhibits MC activation through changes in IL-33/ST2 signaling and NFB translocation.

PI_NAMEs: FRANCIS, HEATHER L (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: 3-Dimensional;Affect;antagonist;Anti-Inflammatory Agents;Antioxidants;autocrine;Automobile Driving;bile duct;Biliary;cell motility;cholangiocyte;Cholestasis;Circadian Rhythms;Complex;curative treatments;Data;disease phenotype;Disease Progression;Down-Regulation;Elements;Family;Feedback;Fibrosis;Hepatic;Hepatocyte;Histamine;Histamine Receptor;Human;Immune system;In Vitro;in vivo;in vivo Model;Infiltration;Inflammation;inhibitor;Injections;Injury;Interleukin-1 Receptors;knock-down;Ligands;Link;Liver;Liver Fibrosis;liver injury;mast cell;Measures;Mediating;Mediator;Melatonin;member;Modeling;Mus;novel;Organoids;Orphan;Outcome;paracrine;Phenotype;primary sclerosing cholangitis;Prognosis;Property;Reaction;receptor;Receptor Signaling;Regulation;repaired;Resolution;Role;senescence;Signal Transduction;Source;System;Tissues;translational study

PROJECT_TITLE: The Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and Damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Prevention

ORG_CITY: SAN ANTONIO

ORG_NAME: TEXAS BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: Project Narrative Myeloid cells are major cell types that harbor HIV in the brain during HIV infection. Eradication of HIV in these cells is critical for a cure of HIV-caused neurological disorders in the central nervous system. We will test a novel CRISPR-based genome editing technology in a non-human primate model to eliminate the viruses that inserted in the genome of myeloid cells for a cure of HIV infection in the brain.

PI_NAMEs: HU, WENHUI ;LING, BINHUA "JULIE"  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acute;adenovirus mediated delivery;Animals;antiretroviral therapy;Bar Codes;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier penetration;Brain;Brain region;brain size;Capsid;CCL2 gene;CCR5 gene;cell type;Cells;Central Nervous System;Chinese;Chronic Phase;Clinical;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Cytoprotection;Data;DNA;Early treatment;efficacy evaluation;Epidemic;Excision;gene editing technology;gene therapy;Genes;Genome;genome editing;genome editor;Goals;Guide RNA;high risk;high risk population;HIV;HIV Infections;HIV-1;HIV/AIDS;humanized mouse;Immunotherapy;In Vitro;in vivo;Individual;Infection;Injections;Intervention;Intravenous;Latent virus infection phase;Libraries;Macaca;Macaca mulatta;Macrophage;Measurement;Mediating;Microglia;Modeling;Monitor;Monkeys;mouse model;Mus;Myelogenous;Myeloid Cells;Names;Nervous System Disorder;neural;neuroAIDS;neurocognitive disorder;neuroinflammation;nonhuman primate;novel;novel strategies;Outcome;Plasma;Play;prevent;Prevention;Prevention therapy;promoter;Proviruses;Recommendation;Regimen;Reporter;Residual state;Role;Serotyping;Shock;Site;SIV;Source;Specificity;System;Technology;Testing;Therapeutic Effect;Time;Tissues;treatment guidelines;Vero Cells;viral detection;viral rebound;Viral reservoir;Viremia;Virus;Virus Diseases

PROJECT_TITLE: Brain myeloid cell-targeted multiplexed gene editing for SIV/HIV eradication


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: PITTSBURGH

ORG_DEPT: CHEMISTRY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative TERRA (telomere repeat containing RNA) is overexpressed in telomerase-free cancer cells that use an alternative lengthening of telomere (ALT) pathway for telomere maintenance. The effort to use TERRA for ALT cancer diagnosis and therapy is hindered by the lack of tools to visualize TERRA accurately in fixed and live cells. Based on our initial success in detecting TERRA with gPNA probes, we will design gPNAs that can bind to TERRA with high selectivity and low background and will deliver gPNA to live cells to monitor TERRA dynamics in real time. Our tools can be adapted to study other RNAs to determine their roles in various cancers and provide a molecular basis for targeting RNAs for cancer therapy.

PI_NAMEs: ARMITAGE, BRUCE A. (contact);ZHANG, HUAIYING

PROGRAM_OFFICER_NAME: BECKER, STEVEN

PROJECT_TERMS: Affinity;Binding;Biological Markers;cancer cell;cancer diagnosis;cancer therapy;Cancerous;cell fixing;Cell Physiology;Cells;cellular imaging;Characteristics;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Cytosol;Data;design;Detection;Development;Diagnosis;DNA;DNA Probes;Endosomes;Engineering;Exhibits;experimental study;Fluorescence;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;Functional disorder;Genetic Transcription;Glutamates;Growth;Image;improved;insight;Investigation;Label;Length;Libraries;Link;live cell imaging;Malignant Neoplasms;Methods;Molecular;Monitor;Nature;novel;novel therapeutic intervention;Nucleotides;overexpression;Pathway interactions;Polymers;Process;RNA;RNA Sequences;RNA-Binding Proteins;Role;Signal Transduction;Source;Specificity;success;Tail;Telomerase;telomere;Telomere Maintenance;Telomere Pathway;Time;tissue fixing;Tissues;tool;Transcript;Untranslated RNA;vector;Visualization;Work

PROJECT_TITLE: Fluorescent gammaPNA Miniprobes for Imaging Telomeric RNA


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Dietary Supplements;Genetics;Infant Mortality;Infectious Diseases;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Zinc deficiency increases the risk for infections during pregnancy. Perinatal bacterial infections often originate in the vagina, where asymptomatic bacterial colonization leads to ascending intrauterine infection followed by preterm labor, stillbirth, or neonatal infection. As part of a long-term goal to identify novel approaches to prevent and treat of perinatal infections, this proposal will investigate how zinc alters the ability of a common perinatal pathogen, Group B Streptococcus, to colonize and infect the female reproductive tract.

PI_NAMEs: DOSTER, RYAN S (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Academic Medical Centers;Adult;Area;Bacterial Infections;Bacterial Physiology;career;career development;Cells;clinical training;Communicable Diseases;Core Facility;Data;Development;dietary;early onset sepsis;Epithelial Cells;Epithelium;Event;female reproductive tract;Fetal Membranes;Future;Genetic;Genetic Transcription;Genomics;Glucose;Goals;Group B Streptococcus colonization;host colonization;Human;human model;Immune response;Impairment;In Vitro;in vitro Model;in vivo;Infection;infection risk;Inflammatory Response;Innate Immune Response;innovation;instructor;instrument;intraamniotic infection;intrauterine infection;Link;Medicine;Mentors;Mentorship;Microbial Biofilms;microbial host;Microscopy;Modeling;mouse model;multidisciplinary;Mus;Mutagenesis;mutant;neonatal infection;neonatal morbidity;Neonatal Mortality;neonatal sepsis;novel strategies;Nutrient;organ on a chip;pathogen;Pathogenesis;Pathway interactions;Pediatrics;Perinatal;Perinatal Infection;Physicians;Pregnancy;Pregnant Women;premature;Premature Birth;Premature Labor;prevent;Production;Program Development;Regulator Genes;Regulatory Pathway;reproductive tract;Research;Research Personnel;Resolution;response;Risk;Risk Factors;Role;Scholarship;Scientist;stillbirth;Stimulus;Streptococcal Infections;Streptococcus Group B;Supplementation;Techniques;Technology;Testing;Tissue membrane;Tissues;transcriptome;transcriptomics;United States;Vagina;Woman;Work;Zinc;Zinc deficiency;Zinc supplementation;zinc-binding protein

PROJECT_TITLE: Defining the impact of zinc on Streptococcus agalactiae biofilm and colonization

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Pediatric;Women's Health Research

ORG_CITY: SAN LUIS OBISPO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CALIFORNIA POLY STATE U SAN LUIS OBISPO

PHR: NARRATIVE Maternal sensitivity and contingent responsiveness to infant behavioral cues is an important contributor to infants’ developing capacities to self-regulate. During early infancy, feeding interactions comprise a significant portion of mother-infant dyadic interactions and high-quality feeding interactions provide both nutritive and socioemotional benefits; recent data from our laboratory suggest that, for many dyads, mothers’ sensitive responsiveness during feeding interactions is routinely impacted by the omnipresence of portable technology. The objective of the proposed research is to better understand the development and possible impacts of maternal technology use on infant feeding interactions, emotion and intake regulation, and sociobehavioral and growth outcomes.

PI_NAMEs: VENTURA, ALISON K. (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Achievement;Address;Age;Age Months;Attention;Behavioral;behavioral response;Birth;Bottle feeding;Breast;Caregivers;Cellular Phone;Characteristics;Child;Code;COVID-19 pandemic;Cues;Data;depressive symptoms;Development;Devices;diaries;Distress;dyadic interaction;early childhood;Eating Behavior;emotion regulation;Emotional;Emotions;Energy Intake;Equilibrium;Exhibits;experimental study;Family;feeding;Foundations;Growth;handheld mobile device;infancy;Infant;Infant Development;infant outcome;Informal Social Control;innovation;Intake;Intervention;Laboratories;Longitudinal Studies;Mediating;Mothers;Nature;negative affect;novel;obesity risk;Outcome;Pattern;Play;portability;Postpartum Period;Pregnancy Trimesters;Pregnant Women;prenatal;preservation;Problem behavior;Protocols documentation;Questionnaires;recruit;Regulation;Reporting;Research;response;Risk;risk minimization;sex as a biological variable;skills;Social Behavior;Social Distance;Societies;Stress;stress reactivity;Technology;Temperament;Testing;Third Pregnancy Trimester;Time;tv watching;Weight Gain;Woman

PROJECT_TITLE: Maternal technology use during feeding and infant self-regulation and growth


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: BIOPHYSICS

ORG_NAME: STANFORD UNIVERSITY

PHR: The malfunction of chloride ion channels and transporter (CLCs) – proteins critical for human physiology – has been linked to musculoskeletal, cardiovascular, and neurological disease. Although the functions of some CLCs are well understood, others remain poorly described, in large part due to the lack of selective 'tools' for analyzing the mechanisms of these proteins in regulating cellular processes. We are advancing high-precision chemical agents to study CLC-2, a chloride-selective ion channel expressed broadly throughout the brain and implicated in epilepsy as well as other disorders of the central nervous system.

PI_NAMEs: DU BOIS, JUSTIN ;HUGUENARD, JOHN R;MADUKE, MERRITT C (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Action Potentials;Acute;Affect;Antibodies;Biotin;Brain;Carbazoles;Cardiovascular Diseases;Carrier Proteins;Cell membrane;Cell Physiology;Central Nervous System;Central Nervous System Diseases;Chemical Agents;Chemicals;Chloride Channels;Chloride Ion;Chlorides;Collection;Data;design;differential expression;Disease;Docking;efficacy validation;Electrolyte Balance;Electrophysiology (science);empowerment;Epilepsy;experimental study;extracellular;Family;fluorescence imaging;Hippocampus;Homologous Gene;Human;Image;imaging probe;improved;inhibitor;Inhibitory Synapse;Investigation;Ion Channel;knock-down;Knockout Mice;Label;Laboratories;Length;Libraries;Ligands;Link;Membrane;Membrane Proteins;Metabolic;Methods;Molecular;Molecular Mechanisms of Action;Muscle;Musculoskeletal Diseases;mutant;Mutation;Nature;Nervous System Disorder;Nervous System Physiology;Neuroglia;neuronal excitability;Neurons;Neurosciences;neurotransmission;novel;patch clamp;Physiological;Physiology;Positioning Attribute;postsynaptic;Presynaptic Terminals;programs;protein function;Proteins;Publishing;receptor;Regulation;Research;response;Role;Site-Directed Mutagenesis;Slice;Small Interfering RNA;small molecule;Specificity;Streptavidin;Structure;Structure-Activity Relationship;Synapses;Synaptic Transmission;Synthesis Chemistry;Testing;Thalamic structure;Tissues;tool;voltage;Whole-Cell Recordings;Work

PROJECT_TITLE: Small-molecule probes for study of CLC-2 chloride-channel function in the central nervous system

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Cardiovascular;Hematology;Lung

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE This Stimulating Access to Research in Residency program is designed to provide clinical residents with the tools, mentorship, and support necessary to conduct high-impact research at a time when their emerging patient care responsibilities may be awakening a new appreciation for the need for clinically-relevant scientific investigation. As such, it addresses the need for clinician scientists who combine first-hand perspective on the diagnosis, prevention, or treatment of heart, lung, and blood diseases with the methodologic, collaborative, and leadership skills necessary to make important scientific discoveries.

PI_NAMEs: HUANG, ALISON  (contact);SINGER, JONATHAN PAUL

PROGRAM_OFFICER_NAME: SCHOPFER, DAVID WESLEY

PROJECT_TERMS: Address;Anesthesia procedures;Basic Science;Belief;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;career;career development;Clinical;clinical investigation;Clinical Research;Clinical Sciences;clinically relevant;cohort;Communication;Communities;Complement;Coupled;Credentialing;Dedications;design;Diagnosis;Discipline of obstetrics;dissemination research;Doctor of Philosophy;education resources;Educational Status;Emergency Medicine;Ensure;epidemiology study;experience;Faculty;faculty mentor;faculty research;Foundations;Funding;Future;Goals;Gynecology;Heart Diseases;Hematological Disease;Hematology;human subject;human tissue;implementation research;Individual;Influentials;Institution;Internal Medicine;Investigation;Laboratories;Leadership;Left;Link;Lung;Lung Diseases;Medicine;Mentors;Mentorship;Methodology;Molecular Medicine;multidisciplinary;National Heart, Lung, and Blood Institute;Non-Malignant;Operative Surgical Procedures;Pathway interactions;Patient Care;Pediatrics;population based;Population Sciences;Prevention;Professional Competence;programs;recruit;Research;research and development;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Residencies;Resources;respiratory;Science;Scientist;skills;skills training;Structure;success;support network;System;Time;tool;Training;Training Programs;Translating;Translational Research;translational scientist;Work

PROJECT_TITLE: Promoting Clinical and Translational Science Training and Career Development for Residents


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: One of the most important mechanisms by which nerve cells communicate with one another is signaling at chemical synapses, junctions between nerve cells where a released neurotransmitter is detected by neighboring cells, initiating electrical and chemical signaling pathways. This mechanism of signal transduction at chemical synapses not only underpins genetically encoded messaging pathways, such as those involved in breathing and cardiac function, but it is also central to learning and memory. The research supported by this proposal is focused on elaborating the molecular mechanisms of signaling at chemical synapses.

PI_NAMEs: GOUAUX, JAMES E (contact)

PROJECT_TERMS: Agonist;Alzheimer's Disease;Amino Acid Sequence;AMPA Receptors;Antibodies;Applications Grants;Autoimmune Diseases;Binding;Biochemical;Brain;brain tissue;Breathing;Cations;Cell Communication;Cells;Cerebellum;Chemical Synapse;Chemicals;Complex;copolymer;crosslink;Cryoelectron Microscopy;Cysteine;design;Detergents;Development;Electrophysiology (science);Encephalitis;Epilepsy;experimental study;Extracellular Structure;Fab Immunoglobulins;Family;Foundations;Glutamate Receptor;glutamatergic signaling;Glutamates;Glycine;Hand;heart function;Hippocampus;Human;ifenprodil;Immunoglobulin Fragments;Individual;Investigation;Ion Channel;ion channel blocker;Ion Channel Gating;Kainic Acid Receptors;Knowledge;Lead;Learning;Ligands;maleic acid;Maps;Mediating;Membrane;Memory;Mental Depression;Methods;millisecond;Molecular;Molecular Structure;Mood Disorders;mutant;N-Methyl-D-Aspartate Receptors;Nervous System;nervous system development;Nervous System Disorder;Nervous System Immune Disorders;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;NMDA receptor A1;novel therapeutics;particle;Pathway interactions;Pharmacology;Physiological;Physiology;Play;Positioning Attribute;Predisposition;Property;Protein Subunits;Proteins;receptor;Receptor Activation;receptor function;Recombinants;Research;Research Support;Rodent;Role;Schizophrenia;Signal Pathway;Signal Transduction;Site;small molecule;stoichiometry;Structure;Styrenes;Synapses;Testing;Therapeutic Agents;three dimensional structure;Time;trafficking;Transmembrane Domain;Zinc

PROJECT_TITLE: 3D Structure and Function of Ligand-Gated Ion Channels

STUDY_SECTION: BPNS

STUDY_SECTION_NAME: Biophysics of Neural Systems Study Section[BPNS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Congenital Structural Anomalies;Emerging Infectious Diseases;Genetics;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

PHR: PROJECT NARRATIVE Viruses that infect developing fetal tissue can cause major birth defects in the process of replicating. Zika virus is one such virus that coopts a host protein to promote its replication, and in doing so disrupts brain development. Studies aimed at unraveling the molecular mechanisms linking Zika virus replication and neuropathogenesis will provide insight into an important human pathogen, and shed light on rare hereditary disease involving the same developmental pathway.

PI_NAMEs: SHAH, PRIYA SHIRISH (contact)

PROJECT_TERMS: Alleles;Amino Acids;Biochemical;Biological Assay;Brain;brain size;Cell division;Chemicals;Collaborations;Congenital Abnormality;Cytomegalovirus;Development;developmental disease;Disease;Drosophila genus;drug development;Etiology;experimental study;Fetal Tissues;Future;Genes;Genetic Determinism;Genetic Predisposition to Disease;Goals;Head;Hereditary Disease;Human;human pathogen;In Vitro;in vivo;Individual;Infection;Inherited;insight;Integration Host Factors;Intellectual functioning disability;knock-down;Link;Mediating;Methods;Microcephaly;Mitosis;Modeling;Molecular;mouse model;Mus;Mutagenesis;mutant;Mutation;mutation screening;nerve stem cell;Nervous System Disorder;Neuropathogenesis;Nonstructural Protein;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;Phosphorylation;Physiological;Process;Proteins;Proteomics;Publishing;recruit;Replication-Associated Process;Reporter;Resolution;Role;Rubella virus;Scaffolding Protein;Site;System;Testing;therapeutic target;Transgenic Organisms;Variant;Viral;Viral Pathogenesis;Virus;virus host interaction;Virus Replication;Work;Zika Virus;ZIKV infection

PROJECT_TITLE: Molecular mechanisms linking viral replication and neuropathogenesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This project will investigate the natural history and long-term prognostic significance of MRI-based measures of microvascular dysfunction over the first 3 years after traumatic brain injury (TBI). Insights gained from this work will provide a better understanding of TBI-related disease processes and contribute to the identification of novel therapeutic targets for TBI-related neurodegeneration and other Alzheimer's Disease Related Dementias.

PI_NAMEs: WARE, JEFFREY B (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acceleration;Affect;Aging;Alzheimer's disease related dementia;Atrophic;Automobile Driving;Axon;axon injury;Blood;Blood brain barrier dysfunction;Blood Vessels;blood-brain barrier permeabilization;Brain;Brain Injuries;brain magnetic resonance imaging;brain tissue;brain volume;cerebral atrophy;Cerebrovascular Circulation;cerebrovascular reactivity;Chronic;Classification;Clinical;Clinical Research;Cognitive;Control Groups;Dementia;Deterioration;Development;Diffusion Magnetic Resonance Imaging;disability burden;Disease;effective therapy;endophenotype;Evolution;Exhibits;extracellular;follow-up;functional decline;Functional disorder;gray matter;Hospitalization;Human;Humanities;hypoperfusion;Image;imaging biomarker;Impaired cognition;Impairment;improved;indexing;Individual;Injury;injury-related death;insight;Investigation;late life;Link;long term recovery;Magnetic Resonance Imaging;Measures;Microvascular Dysfunction;Modeling;Monitor;Morbidity - disease rate;morphometry;mortality;Myelin;Myelin Water Imaging;Natural History;Nature;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;neuron loss;neuronal cell body;Neurons;neuropathology;Neuropsychology;new therapeutic target;normal aging;novel;Outcome;outcome prediction;Participant;Pathologic;Pathology;Patient Recruitments;Patient-Focused Outcomes;Pattern;Perfusion;pre-clinical;pre-clinical research;Predictive Value;Process;Prognosis;prognostic significance;prognostic value;programs;progressive neurodegeneration;Research;Risk Factors;Role;Survivors;TBI Patients;Techniques;Testing;therapy development;Thick;time interval;Tissues;Traumatic Brain Injury;vascular cognitive impairment and dementia;vascular injury;Water;white matter;Work

PROJECT_TITLE: Longitudinal MRI Investigation of Traumatic Microvascular Injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pain Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DENVER

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

ORG_STATE: CO

PHR: PROJECT NARRATIVE Race-based pain treatment disparities are well-established, existing across pain types and treatment contexts. Alongside patient-level and system-level factors, clinician-level biases have been implicated in disparate pain care; however, we do not yet understand the specific race-perception mechanisms that may serve as antecedents to biased care, and current intervention strategies have achieved limited success in mitigating bias. The current work tests an integrated account of race perception processes theorized to underlie race disparities in pain care and offers an initial examination of a psychological intervention targeting race perception as a route to more equitable care.

PI_NAMEs: LLOYD, EMILY PAIGE (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Accident and Emergency department;Address;Affective;American;Attenuated;Award;Behavior;Belief;Black American;black patient;Black race;career;career development;Caring;Categories;caucasian American;Caucasians;Cognitive;cognitive process;cost estimate;Data;design;Development;Development Plans;Discrimination;Disfluent;Disparate;Disparity;Doctor of Philosophy;Empathy;Equity;Ethics;Exclusion;experience;Family Practice;Funding;Future;Goals;Guidelines;Health;health care disparity;health determinants;health disparity;Health Services Research;Individual;Individuation;insight;Institute of Medicine (U.S.);Institution;Intensive Care;Internal Medicine;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Learning;Literature;Long term disability;Measurement;Medical;Mentorship;Methodology;Modeling;multi-racial;multidisciplinary;non-verbal;nonverbal bias;novel;novel strategies;Pain;Pain management;pain sensitivity;Participant;Patient Care;Patients;Pattern;Perception;Persons;pilot test;Population;Positioning Attribute;Prejudice;Process;Productivity;programs;psychologic;Psychological Theory;Psychologist;Psychology;Race;racial bias;racial disparity;racial diversity;Recommendation;recruit;Research;Research Personnel;Research Support;Resources;response;Route;Sampling;Scientist;skills;social;Standardization;statistics;Stereotyping;success;System;Testing;theories;therapy design;Training;Training Activity;Training Programs;treatment disparity;Treatment Efficacy;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Racial Biases in Pain Treatment: Tests of pain-care recommendations, treatment biases, and race perception mechanisms


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: DURHAM

ORG_DEPT: BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Isolates of the fungal pathogen Cryptococcus can vary greatly in their propensity to cause morbidity and mortality. This research will advance public health by identifying dif- ferences in genes and gene networks that underlie variation in disease related traits for three species of Cryptococcus. A deeper understanding of how genetic variation inﬂu- ences virulence traits may lead to new approaches for the treatment and prevention of cryptococcal disease.

PI_NAMEs: HEITMAN, JOSEPH ;MAGWENE, PAUL MITAARI (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Affect;Alleles;Amoeba genus;Animal Model;Animals;anti-fungal agents;Basidiomycota;Benign;Biological Models;Biology;capsule;Cell model;Cells;Cellular Morphology;Cessation of life;Chemicals;Chromosome Mapping;Communities;comparative;Complex;Cryptococcosis;Cryptococcus;Cryptococcus gattii;Cryptococcus neoformans;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Disease;Drug resistance;Ecology;Environment;Etiology;Event;Evolution;Exhibits;Foundations;Funding;Fungal Drug Resistance;fungus;gene network;Genes;Genetic;genetic architecture;Genetic Determinism;Genetic Epistasis;genetic resource;Genetic study;Genetic Transcription;genetic variant;Genetic Variation;genome resource;Genomic approach;Genotype;High temperature of physical object;Human;Infection;insight;Invaded;Maps;Medical;member;Methodology;microbial;microorganism interaction;Morbidity - disease rate;Morphology;mortality;novel;novel strategies;novel therapeutic intervention;opportunistic pathogen;Organ;pathogen;Pathogenesis;pathogenic fungus;Pathogenicity;Pathway interactions;Pattern;Phagocytes;Phenotype;Physiological;Polysaccharides;Population;Prevention;Public Health;Quantitative Trait Loci;Regulation;Research;Resources;Shapes;Signal Pathway;Signal Transduction;Sister;System;Testing;Tissues;tool;trait;Transcriptional Regulation;Variant;Virulence;Yeasts

PROJECT_TITLE: The Genetic Basis of Virulence in Cryptococcus Neoformans

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The Overall Goal of this Centers of Biomedical Research Excellence Phase I proposal is the creation of an Integrative Center for Precision Nutrition and Human Health at the University of Hawai’i at Manoa. Precision nutrition is a new component of medicine that considers differences in how nutrients are absorbed and converted to energy, resulting in widely varying dietary and nutrient requirements. Genes, environment, culture and customs, dietary preferences and economics all contribute to nutrition and overall health. Through culturally-sensitive collaborations between academic researchers and the community, our goal is to promote better nutrition and health widely throughout the community, state and beyond.

PI_NAMEs: BERRY, MARLA J (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: absorption;Adipose tissue;Affect;Area;Behavior;career development;Career Mobility;Centers of Research Excellence;Collaborations;Communities;community based research;community engagement;Community Health;Community Outreach;community partners;community-level factor;Core Facility;cost;culturally appropriate intervention;Custom;Data;Development;Diet;dietary;Dietary Component;dietary requirement;early-career faculty;economic disparity;Economics;Education and Outreach;Environment;Environmental Exposure;Epigenetic Process;Ethnic Origin;Extramural Activities;Faculty;feeding;Food Access;food insecurity;Fostering;Foundations;Fruit;Funding;Future;Genes;Genetic Polymorphism;Genetic Variation;Genome;Goals;Hawaii;Health;Health Benefit;health outcome disparity;Health Promotion;Human;improved;Indigenous;Individual;individual response;innovation;Integrative Medicine;Interdisciplinary Study;Intervention;Investigation;Leadership;Life;Life Style;Lipids;Medicine;Mentors;Metabolic Pathway;microbiome;Modification;Molecular;multidisciplinary;nutrient absorption;nutrition;Nutritional;Nutritional Requirements;Nutritional Study;Outcome;Pathway interactions;Personal Satisfaction;personalized health care;Pharmaceutical Preparations;pharmacologic;Phase;Physical activity;precision medicine;precision nutrition;preference;programs;Quality of life;Regimen;Research;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Stress;success;Technology;Training and Education;Training Programs;Underserved Population;Universities


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition;Precision Medicine

PROJECT_TERMS: Abbreviations;Advisory Committees;Agriculture;Anatomy;Appointment;Biochemistry;Biohazardous Substance;Biological Sciences;Budgets;Burn injury;career development;Cells;Centers of Research Excellence;Child Health;Clinical;college;Communication;Communities;community based participatory research;community engagement;Community Outreach;Core Facility;Development;Educational workshop;Eligibility Determination;Employee;Ensure;Environment;Equipment;Equipment and supply inventories;Evaluation;expectation;Extramural Activities;Faculty;federal policy;Fostering;Foundations;Funding;Future;Goals;Grant;Growth;Guidelines;Hawaii;Health;Health Sciences;Human;Human Resources;human subject;Individual;Maintenance;medical schools;meetings;Mentors;Minority-Serving Institution;Native Hawaiian or Other Pacific Islander;Nutritional Study;Office of Administrative Management;organizational structure;outreach;Physiology;Pilot Projects;precision nutrition;Procedures;Process;programs;Progress Reports;Qualifying;Records;Regulation;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Research Support;scientific organization;Selection Criteria;success;Training;United States National Institutes of Health;Universities;Vertebrates

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Precision Medicine;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: OKIHIRO, MAY MICHIKO (contact)

PROJECT_TERMS: Address;Basic Science;Centers of Research Excellence;Child;Chronic Disease;Clinical Sciences;Collaborations;Communication;Communities;community based research;community engagement;Community Healthcare;community involvement;community organizations;Community Outreach;community-level factor;Complex;Consumption;cultural competence;Data Analyses;Data Set;Development;Diabetes Mellitus;Diet;Eating;economic determinant;economic disparity;Economics;Education;Environment;experience;Family;Family health status;Federally Qualified Health Center;Food;Food Access;Fostering;Goals;Hawaii;Hawaiian;Health;Health Benefit;health disparity;Health Food;Health Knowledge Attitudes Practice;Health Personnel;Human;Immigrant community;improved;indigenous community;Individual;Information Dissemination;innovation;insight;Institution;interest;Investments;Knowledge;Life Style;Link;member;Methodology;Native Hawaiian;neighborhood disadvantage;Neighborhood Health Center;novel;Nutrient;nutrition;nutrition related prevention;Nutritional;Nutritional Study;Obesity;Persons;Policies;Population;Poverty;precision nutrition;Provider;Qualifying;Recording of previous events;Research;Research Personnel;Research Priority;Rural;Rural Community;Shapes;Site;social determinants;social stigma;Societal Factors;Societies;success;System;Training;translational potential;Translational Research;Trust;underserved community

PROJECT_TITLE: Community Engagement and Outreach Core


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative This project investigates the potential for dirty mice, i.e. mice exposed to a diverse microbiome from cohousing with pet shop mice, to transform skin immunology research, as dirty mice may better recapitulate the human skin immune system and consequently human skin disease.

PI_NAMEs: DIVITO, SHERRIE JILL (contact)

PROGRAM_OFFICER_NAME: LEITNER, WOLFGANG W

PROJECT_TERMS: abacavir;Acute;Allogenic;Antigens;Architecture;Biological Assay;Blood;Bone Marrow;Cancer Patient;Cell Survival;Cells;chemotherapy;Clinical;Communities;comparative;conditioning;Cutaneous;Data;Development;Disease;disease model;drug development;Drug Exposure;Drug Hypersensitivity;dysbiosis;Ear;Ensure;Environment;Exposure to;Fibroblasts;Flow Cytometry;Genetic Transcription;germ free condition;graft vs host disease;Health;healthcare burden;Hematopoietic Stem Cell Transplantation;Histologic;Histology;HLA-B Antigens;Human;human data;human model;IACUC;Immune;immune function;Immune response;Immune system;Immunity;Immunofluorescence Immunologic;Immunofluorescence Microscopy;Immunological Models;Immunology;Infection;Inflammation;innovation;insight;irradiation;keratinocyte;Laboratory mice;lymph nodes;Manuscripts;Mediating;Mediator;Memory;Memory B-Lymphocyte;microbial;microbiome;microbiota;Microscopy;Modeling;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;novel;Pathogenesis;Patients;Pharmaceutical Preparations;Phenotype;Play;Population;prevent;prospective;Proteins;Publications;Reaction;recruit;Regulatory T-Lymphocyte;Research;Role;secondary lymphoid organ;sex;Shapes;side effect;single-cell RNA sequencing;Site;Skin;skin disorder;skin hypersensitivity;Skin Tissue;Splenocyte;Stains;T cell receptor repertoire sequencing;T memory cell;T-Lymphocyte;Techniques;Testing;Thick;tissue resident memory T cell;Tissues;tool;transcriptome sequencing;Transgenic Mice;translational model;Translational Research;Transplantation;Transplantation Conditioning;Work

PROJECT_TITLE: Investigating the skin-immune system in dirty mice

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Nutrition;Precision Medicine

PI_NAMEs: MAUNAKEA, ALIKA KEOLAOKALANI (contact)

PROJECT_TERMS: Analytical Chemistry;Animals;Area;Basic Science;Berry;Bioinformatics;Biomedical Research;Budgets;Cancer Center;Centers of Research Excellence;Charge;Clinical Research;Collaborations;Collection;Communities;community engagement;Community Outreach;Consultations;Contracts;Core Facility;cyber infrastructure;Data;data centers;data visualization;design;Development;Diet and Nutrition;Doctor of Philosophy;Education;Educational workshop;effectiveness evaluation;Ensure;epigenomics;Equipment;Evaluation;Faculty;flexibility;Food;Fostering;Foundations;Funding;Future;Goals;Grant;Hawaii;Health;health disparity;Hospitals;Human;Image;imaging facilities;improved;Libraries;lipidomics;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Medical;Medical center;Mentors;Metabolic;metabolic phenotype;metabolomics;Metagenomics;microbial genomics;microbiome;microscopic imaging;Microscopy;Monitor;National Institute on Minority Health and Health Disparities;next generation;novel;nutrition;Nutritional Study;organizational structure;Outcome;Peer Review;Persons;Phenotype;Positioning Attribute;Postdoctoral Fellow;precision nutrition;prisma;Publications;Quality of life;recruit;Reference Standards;Research;Research Activity;research facility;Research Personnel;Research Support;Resource Sharing;Resources;Science;Services;Statistical Data Interpretation;Structure;System;Taxus;Technology;Training;Training and Education;transcriptomics;Translational Research;Universities

PROJECT_TITLE: Consortium of Research Advancement Facilities and Training


NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Nutrition;Obesity;Pediatric;Precision Medicine;Prevention;Social Determinants of Health

PI_NAMEs: ESQUIVEL, MONICA KAZLAUSKY (contact)

PROJECT_TERMS: 8 year old;Adult;Affect;Animals;Assessment tool;Biological Markers;Calories;Caregivers;Child;Childhood;Chronic Disease;Clinic;Clinical;Communities;community academic partnership;community based participatory research;community based research;Consumption;cost;Country;Data;Databases;density;Development;Diet;Diet Habits;dietary;Dietary intake;Dietary Intervention;Dietary Practices;Disease;disorder risk;Doctor of Philosophy;early childhood;economic disparity;effectiveness evaluation;effectiveness measure;experience;Family;Family health status;farmers markets;Feasibility Studies;Food;food insecurity;Frequencies;Fruit;fruits and vegetables;Goals;gut microbiome;Hawaii;Health;Health Benefit;health disparity;Health Personnel;Health Promotion;Healthcare;high risk;Home;Household;Human;Improve Access;improved;Individual;Influentials;innovation;Intake;Intervention;Intervention Trial;Interview;Knowledge;Life Expectancy;Life Style;Measures;member;Methods;microbiome;microbiome composition;Minority Groups;Native Hawaiian or Other Pacific Islander;neighborhood disadvantage;Nutrient;nutrition;Nutritional;Nutritional Study;Obesity;obesity risk;Overweight;Parents;Participant;Patients;pediatrician;Policies;Population;precision nutrition;professor;programs;Provider;Questionnaires;Randomized;Randomized, Controlled Trials;Records;Reporting;Research;Research Personnel;Research Project Grants;research study;Resources;Rural;Science;Site;Surveys;Time;Trust;United States National Institutes of Health;Universities;Vegetables;voucher;Work

PROJECT_TITLE: Project 1: Keiki Produce Prescription (KPRx) Program: Improving Diet Assessment and Quantifying Health Impacts