NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Inflammation-induced injury to the vital organs is a leading cause of morbidity and mortality following severe trauma; however, the precise mechanisms that control the host immune response are poorly understood. This program will examine key contributions of the vascular endothelium to direct and indirect immunomodulation after traumatic injury. Our goals are to 1) increase our basic understanding of how endothelial cells regulate inflammation; 2) define mechanisms occurring during endothelial dysfunction that drive organ injury; and 3) identify novel therapeutic tools that limit post-injury organ damage and improve trauma patient survival.

PI_NAMEs: CARDENAS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Anabolism;Anti-Inflammatory Agents;Area;Attenuated;Automobile Driving;Award;Binding;Biological;Clinical;COVID-19;Critical Illness;Endothelial Cells;endothelial dysfunction;Endothelium;experimental study;Funding;Goals;Hemorrhagic Shock;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Immune response;immunoregulation;improved;Inflammation;Inflammatory Response;Injury;Innate Immune Response;innovation;Investigation;Knowledge;Mediating;Mission;Modification;Morbidity - disease rate;mortality;Multiple Organ Failure;National Institute of General Medical Sciences;novel;novel therapeutics;Organ;Organ failure;organ injury;Pathogenesis;prevent;programs;Quality of life;receptor;Regulation;Research;Role;Secondary to;Sepsis;Signal Transduction;Sulfate;Surface;System;Therapeutic;Thrombin;tool;translational research program;Transplantation;Trauma;Trauma patient;Traumatic injury;Variant;vascular contributions;Vascular Endothelium

PROJECT_TITLE: Endothelial regulation of inflammation in trauma and hemorrhagic shock

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: TUCSON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE The length of time that antibodies persist after vaccination and infection and the efficacy of these antibodies against related pathogens varies widely. The goal of this proposal is to identify genetic factors and cellular events that control the duration of immunity after vaccination.

PI_NAMEs: BHATTACHARYA, DEEPTA  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: 2019-nCoV;Ablation;Adjuvant;Antibodies;Antibody Formation;Antibody Response;Antibody-mediated protection;Antigens;Award;B-Lymphocytes;Bioinformatics;Cells;Clinical Research;Data;Epigenetic Process;Event;experimental study;Family member;Funding;Genetic;Genetic Epistasis;genetic manipulation;Genetic Transcription;Goals;Human;Humoral Immunities;Immunity;Immunization;imprint;in vivo;Infection;Influenza;Japanese encephalitis virus;Knock-out;Length;life span;Longevity;Maps;Memory B-Lymphocyte;Modeling;Modernization;Molecular;Mus;Nature;pathogen;Pathway interactions;Pattern;Plasma Cells;programs;response;Route;sensor;single cell ATAC-seq;single-cell RNA sequencing;Structure of germinal center of lymph node;Testing;Time;tool;transcription factor;Transcriptional Regulation;Vaccination;Work

PROJECT_TITLE: Transcriptional Regulation of Antibody Responses and Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-F(90)]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Lymphatic Research;Obesity;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Wound Healing and Care

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) Dysfunction in lymphatic vessels is associated with development of many diseases, including obesity and metabolic disease, chronic wound and cancer, aging and Alzheimer’s disease, inflammation and cardiovascular diseases; however, therapeutic lymphangiogenesis for preventing and treating these diseases has not been widely explored partly due to the unavailability of a clinically-relevant cell source and controllable matrix environment. This research program focuses on strategies to utilize clinically-relevant stem cells and synthetic materials for controlling lymphatic networks formation. The expected outcomes from this research program has the potential to advance our basic understanding of lymphatic vasculatures in health and disease, as well as innovative therapeutics for a myriad of diseases that will benefit from therapeutic lymphangiogenesis.

PI_NAMEs: HANJAYA-PUTRA, DONNY  (contact)

PROJECT_TERMS: absorption;Aging;Alzheimer's Disease;Attenuated;Biocompatible Materials;Biology;Biomedical Engineering;Blood capillaries;Blood Vessels;Cardiovascular Diseases;Cardiovascular system;Cells;chronic wound;clinical application;clinically relevant;Development;Dietary Fats;differentiation protocol;Disease;Edema;engineered stem cells;Environment;Extracellular Fluid;fluid flow;Functional disorder;Goals;Health;Homeostasis;Human;human pluripotent stem cell;Immune;Inflammation;Inflammatory Response;innovation;interdisciplinary approach;Knowledge;Link;Liquid substance;Lymphangiogenesis;Lymphatic;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vasculature;lymphatic vessel;Malignant Neoplasms;Metabolic Diseases;Microfluidics;Modeling;Molecular;Morphogenesis;Muscle Cells;Natural regeneration;Obesity;Outcomes Research;Physiology;pluripotent stem cell differentiation;prevent;programs;public health relevance;Reproducibility;Research;Source;stem cell differentiation;stem cells;Systems Biology;Testing;Therapeutic;therapeutic target;Thoracic Duct;tissue regeneration;Tissues;trafficking;Vascular System;Wound models

PROJECT_TITLE: Engineering the Stem Cell Microenvironment for Lymphatic Regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: ATHENS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative Iron-dependent enzyme-mediated oxygen activation is a life-sustaining process that drives the metabolism of aerobic organisms. However, dissecting the contribution of ligand sets to oxygen activation is challenging due to the complexity of catalytic centers. By simplifying the ligand sets to solely nitrogen-donor ligands, we aim to address the scientific challenge by comparative investigation of heme and non-heme iron-dependent oxygenases of biomedical significance.

PI_NAMEs: WANG, YIFAN  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Contribution of Ligand Sets to Oxygen Activation in Iron-dependent Biocatalysts

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

ORG_STATE: CA

PHR: Project Narrative O-GlcNAc is the only known intracellular glycosylation signaling pathway in mammals, and is implicated in nearly every basic biological process from signal transduction and gene expression to cell division and differentiation. Despite its widespread reach, we lack a foundational understanding of this post-translational modification, largely due to the lack of tools to unambiguously identify O-GlcNAcylated proteins or to perturb the essential O-GlcNAc transferase gene (Ogt). Here, we propose to apply new groundbreaking tools we have recently developed to uncover the principles of O-GlcNAc signaling, including its dynamics, how its propagated, and its role in transcriptional control of stem cell differentiation.

PI_NAMEs: MYERS, SAM ANTHONY (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adaptor Signaling Protein;Affect;Amino Acid Sequence;Antibodies;Biochemical;Biological Process;Biology;Cell Differentiation process;Cell division;Cell Physiology;Cells;Chemicals;Complex;Coupled;crosslink;Cues;Cytoplasmic Protein;Data;Deposition;Development;Disease;embryonic stem cell;Excision;extracellular;flexibility;follow-up;Fractionation;Gene Expression;Gene Expression Process;glycoproteomics;glycosylation;Health;Hydrolase;innovation;insight;Investigation;Knowledge;mammalian genome;Mammals;Mass Spectrum Analysis;Modification;Monitor;Nature;Nuclear Proteins;O-GlcNAc transferase;Peptides;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;pluripotency;Post-Translational Protein Processing;programs;Proteins;Reagent;Research;Resolution;response;Role;Sampling;Serine;Signal Pathway;Signal Transduction;Site;stem cell differentiation;Technology;Threonine;Tissues;tool;Totipotency;Transcriptional Regulation

PROJECT_TITLE: Elucidating the signaling and protein interaction networks of the O-GlcNAc transferase during embryonic stem cell state transitions

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: Narrative: Bladder diseases like overactive bladder, underactive bladder, and diabetic bladder dysfunction significantly affect health-related quality of life on those patients. This project seeks to investigate the molecular pathways which control the bladder activities. If we understand the mechanism of bladder contraction and relaxation then we can design logical therapeutic strategies to alleviate, control and prevent these debilitating symptoms.

PI_NAMEs: YU, WEIQUN  (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adenosine;Adrenergic Agents;Affect;Age;Aging;Agonist;Appearance;ATP Hydrolysis;Atropine;Autoimmune;Autoimmune Diseases;Bladder;Bladder Control;Bladder Diseases;Bladder Dysfunction;Bladder Tissue;Clinical;Comparative Study;cost;Cost of Illness;Data;debilitating symptom;design;Diabetes Mellitus;diabetic;differential expression;Disease;Drug Targeting;ecto-nucleotidase;Enzymes;Exhibits;Functional disorder;Genes;health related quality of life;Human;human disease;human female;Impairment;insight;Kinetics;Knock-out;Knockout Mice;Knowledge;loss of function mutation;lower urinary tract symptoms;LoxP-flanked allele;male;Mediating;Mediator;Molecular;mouse model;Mouse Strains;Mus;Muscarinic Antagonists;Muscarinics;mutant mouse model;Mutation;Myocardium;Nature;Nerve;Neurodegenerative Disorders;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Overactive Bladder;Partner in relationship;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Play;Population;prevent;Purinoceptor;receptor;receptor expression;receptor function;Receptor Signaling;Regulation;Relaxation;Reporting;Research;Rodent;Role;sex;Signal Pathway;Signal Transduction;Smooth Muscle;Smooth Muscle Myocytes;social;Stimulus;Symptoms;telokin;Testing;Therapeutic;Time;Tissues;Transgenic Mice;Translating;Urination;Visceral

PROJECT_TITLE: Role of Ectonucleotidase in Voiding Function and Dysfunction

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Patient Safety;Prevention;Pulmonary Hypertension;Rare Diseases;Sickle Cell Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: As patients with sickle cell disease live to adulthood, they are developing heart and lung disease that leads to early death. Blood and heart ultrasound tests can identify patients at risk. In this clinical trial we will evaluate whether monthly red blood cell transfusions can improve their symptoms and prevent hospitalization and death.

PI_NAMEs: BROOKS, MARIA MORI (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Acute;acute chest syndrome;Address;adjudication;Adult;Adverse event;Aging;Alloimmunization;Antigens;Biological Markers;Blood;Blood specimen;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cellular Phone;Certification;Cessation of life;Chronic;Chronic Kidney Failure;chronic stroke;Classification;Clinical;clinical infrastructure;Clinical Investigator;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;cohort;Collaborations;Communication;Communities;Consensus;Data;data access;Data Analytics;data centers;Data Collection;Data Coordinating Center;Data Files;data management;data quality;Data Reporting;Data Set;data sharing;Databases;Death Rate;design;Development;Disease Progression;disorder risk;Doppler Echocardiography;Echocardiography;Effectiveness;Ensure;epidemiologic data;Erythrocyte Transfusion;Erythrocytes;Event;Exclusion Criteria;exercise capacity;experience;Functional disorder;functional loss;Guidelines;hazard;health related quality of life;Healthcare;Heart;Heart Diseases;Hemolytic Anemia;Hepatic;high risk;Home;Hospitalization;Hospitals;Human Resources;Image;improved;improved outcome;inclusion criteria;Infrastructure;Infusion procedures;Intention;Intervention;Iron;Laboratories;Left;Lung Diseases;lung pressure;Manuals;Manuscripts;Measurement;Measures;Medical center;Meta-Analysis;meter;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;Multiple Organ Failure;Odds Ratio;operation;Organ;Outcome;Pain;Patients;Phase;Population;Preparation;prevent;Prevention;primary outcome;pro-brain natriuretic peptide (1-76);Procedures;Process;Protocols documentation;pulmonary arterial pressure;Pulmonary Hypertension;Quality Control;Random Allocation;Randomized;randomized, clinical trials;Reaction;Recommendation;Recurrence;Registries;Renal function;Reporting;research clinical testing;Research Design;research study;right ventricular failure;Risk;Safety;Scheme;screening;secondary outcome;Sickle Cell Anemia;Site;Specific qualifier value;standard care;standard of care;Statistical Data Interpretation;Stroke;Stroke prevention;Sudden Death;Symptoms;System;Testing;Text Messaging;Therapeutic Intervention;therapeutically effective;Training;Transfusion;Treatment Effectiveness;Ultrasonography;Uncertainty;United States National Institutes of Health;Universities;Variant;Ventricular;Visit;Walking;Whole Blood Exchange Transfusion;Writing

PROJECT_TITLE: 2/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE Trial)


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Public Health Relevance Statement We propose to develop a suite of machine learning methods to identify disease-relevant cell subpopulations from single-cell assays. Those methods will incorporate internal and external clinical phenotype information into single-cell data analysis to dissect biologically and clinically significant subsets from heterogeneous cell populations. Applying those approaches to distinguish phenotype-associated cell subpopulations from single- cell sequencing data will help identify the cell subsets driving the phenotypes, thus facilitating the discovery of cellular targets to treat human diseases.

PI_NAMEs: XIA, ZHENG  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Automobile Driving;Biological;Biological Process;Biotechnology;Cell Count;Cell Therapy;cell type;Cells;Cellular Assay;cellular targeting;Clinical;clinical phenotype;Clinical Research;clinically significant;Complex;Data;Data Analyses;Data Set;design;Detection;Development;Disease;Disease Progression;feature selection;flexibility;Genes;Genetic Transcription;Graph;human disease;improved;Individual;innovation;Learning;learning strategy;Link;loss of function;machine learning method;Measurement;Methodology;Methods;Modeling;Molecular;Mutation;Nail plate;Nature;Neoplasm Metastasis;novel;novel strategies;Performance;Pharmacotherapy;Phenotype;Population;Population Heterogeneity;Prognostic Marker;public health relevance;Rationalization;Sample Size;Sampling;Series;Signal Transduction;simulation;single cell analysis;single cell sequencing;single cell technology;single-cell RNA sequencing;Speed;supervised learning;survival outcome;The Cancer Genome Atlas;theories;therapy resistant;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;treatment response;unsupervised clustering;Water

PROJECT_TITLE: Characterizing phenotype-associated subpopulations from single-cell sequencing data

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Retinal detachment is an ocular emergency that can lead to permanent blindness due to photoreceptor cell death. Detachment of the retina can occur in all ages, from newborns to adults, and is characterized by active infiltration and activation of local microglia and peripheral monocyte/macrophages. Through the successful execution of this proposal, we will gain new mechanistic insights to effectively target these populations and develop novel neuroprotective strategies to prevent vision loss.

PI_NAMEs: MAIDANA, DANIEL ENRIQUE  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Acute;Address;Adult;Advisory Committees;Affect;Age;analytical method;Award;Bioinformatics;Biological Assay;Biometry;Blindness;Blood;Bone Marrow;career;Career Mobility;Cell Death;Cells;Chicago;Chimera organism;Chronic;Clinical;clinically relevant;Data;Death Rate;demographics;Development;Doctor of Philosophy;Early treatment;Emergency Situation;Environment;ethnic minority;Experimental Models;experimental study;Goals;Illinois;Immunology;Immunophenotyping;Impairment;Infiltration;Inflammatory;Inflammatory Response;inherited retinal degeneration;inhibitor;Injury;insight;Institution;K-Series Research Career Programs;Kinetics;Laboratories;Leadership;Macrophage;Macrophage Colony-Stimulating Factor Receptor;Maps;Mediating;Mentors;Mentorship;Methods;Microglia;Modeling;monocyte;Mononuclear;Morphology;multidisciplinary;Mus;Myeloid Cells;Necrosis;neuroprotection;Newborn Infant;novel;Ophthalmology;Outcome;Patients;Peripheral;Phagocytes;Phase;Phenotype;photoreceptor degeneration;Photoreceptors;Physicians;prevent;Productivity;professor;Publishing;racial minority;repaired;Reporter;Research;Research Personnel;response;Retina;Retinal Detachment;Retinal Diseases;Role;Scientific Advances and Accomplishments;Scientific Inquiry;Scientist;skills;small molecule;Specificity;System;Target Populations;Therapeutic;Time;transcriptome;transcriptomics;translational approach;translational potential;Tyrosine Kinase Inhibitor;Universities;vision science;Visual;Woman;Work

PROJECT_TITLE: Defining the Role of Retinal Microglia and Infiltrating Monocytes on Photoreceptor Cell Death in Retinal Detachment


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Sleep Research;Social Determinants of Health

ORG_CITY: LOGAN

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UTAH STATE UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project addresses three key limitations in the field of dementia family caregiving research, by focusing on caregiver cognitive health outcomes, quantifying two daily health behaviors of sleep and activities, considering caregivers' assistance to engage individuals with dementia in daily activities and the dyadic context of caregiving, and a chronic stress biomarker when examining the hypothesized associations. The project will generate critical information on how caregiver cognitive health is associated with daily sleep and activities within the dyadic context, elucidating the social context and biological mechanisms that relate to varying caregiver outcomes.

PI_NAMEs: LIU, YIN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Abbreviations;Accelerometer;actigraphy;Activities of Daily Living;Address;Affect;age acceleration;age related decline;Aging;aging population;Alzheimer's disease related dementia;American;Anxiety;anxiety symptoms;Area;Behavior;biobehavior;Biological;Biological Markers;biopsychosocial;care giving burden;career;caregiver interventions;Caregivers;caregiving;caregiving research;Caring;Characteristics;Chronic stress;Clinical;clinical care;Cognition;Cognitive;cognitive benefits;cognitive function;Communities;comorbidity;Complex;Data Reporting;Dementia;dementia care;Dementia caregivers;dementia caregiving;demographics;depressive symptoms;design;Development;diaries;disability;Distress;Education;Elements;Emotional;Evidence based intervention;Exercise;experience;Family;Family Caregiver;family caregiving;follow-up;Friends;Future;Goals;Growth;Hair;Health;Health behavior;Hydrocortisone;improved;Individual;informal care;innovation;insight;Institutionalization;interest;Intervention;K-Series Research Career Programs;Knowledge;late life;Link;longitudinal design;Measures;Mediating;member;Mental Depression;Mental Health;Mentors;Mentorship;mortality;multilevel analysis;Music;Neurocognitive;neuropsychiatric symptom;novel;older adult;Outcome;Patient Self-Report;Personal Satisfaction;Persons;poor sleep;preservation;primary caregiver;programs;promote resilience;protective factors;Quality of Care;Regulation;Research;Research Personnel;residence;resilience;Risk;Risk Factors;Science;Scientist;Severities;skills;Sleep;sleep behavior;Sleep disturbances;sleep health;sleep quality;sleep regulation;social;Social Controls;Social Environment;Socialization;Specific qualifier value;Stress;therapy design;Training;Training Programs

PROJECT_TITLE: Cognitive Health and Modifiable Factors of Daily Sleep and Activities Among Dementia Family Caregivers

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

PHR: Project Narrative Chronic, low-grade inflammation is a contributing factor to most diseases associated with aging. However, the molecular and cellular mechanisms that regulate chronic inflammation are still being deciphered. We will determine how specific regulatory microRNAs function to control age-dependent inflammatory status through their regulation of T cell metabolism, recruitment of inflammatory myeloid cells, and control of senescence-associated secretory phenotypes, and our work will identify novel therapeutic targets to treat this harmful condition.

PI_NAMEs: DRUMMOND, MICAH J;O'CONNELL, RYAN M (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Activities of Daily Living;aerobic glycolysis;Age;age related;age related chronic disease;aged;Aging;aging population;Anti-Inflammatory Agents;Autoantibodies;Autoimmunity;Biochemical;Biological Assay;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Cellular Metabolic Process;chemokine;Chronic;Cladribine;Clinic;Clinical;clinically relevant;comorbidity;conditional knockout;Data;Diabetes Mellitus;Disease;extend lifespan;frailty;Functional disorder;Gene Expression;gene function;Genes;Glycolysis;Heart Diseases;Helper-Inducer T-Lymphocyte;Human;Immune response;improved;Inflammaging;Inflammation;Inflammatory;inflammatory marker;inhibitor;innovation;insight;insulin sensitivity;Investigation;Knockout Mice;Life;life span;Link;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolic Diseases;Metabolism;MicroRNAs;Modeling;Molecular;Mus;muscle strength;Muscle Weakness;Myelogenous;Myeloid Cells;Nerve Degeneration;new therapeutic target;novel;novel marker;Obesity;older adult;Organ;Outcome;Participant;Pathogenicity;Pathology;Pathway interactions;Phenotype;Play;Population;Prevalence;prevent;Process;Production;programs;recruit;Regulation;Reporting;Research;Risk Factors;Role;senescence associated secretory phenotype;Serum;single-cell RNA sequencing;Societies;stem;T cell regulation;T-Lymphocyte;T-Lymphocyte Subsets;targeted treatment;Therapeutic;Time;Tissues;tool;Translating;Work;young adult

PROJECT_TITLE: MicroRNA regulation of chronic inflammation during aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE TDP-43 proteinopathy is pathologic hallmark of frontal temporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), and also occurs broadly in Alzheimer's Disease (AD). TDP-43 is an RNA-binding protein with multiple functions in mRNA processing, and also implicated in regulating retrotransposon activation. We will decipher the molecular mechanism how TDP-43 regulates the retrotransposon LINE1 RNA accumulation and how the LINE1 RNA elevation perturbs the gene expression landscape, which could contribute to neurodegeneration.

PI_NAMEs: DONG, XIANJUN ;SUN, SHUYING  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Autopsy;C9ORF72;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Data;Degradation Pathway;Development;Disease;DNA;DNA Damage;Elements;Euchromatin;Event;Family;Feedback;Frontotemporal Dementia;Functional disorder;functional genomics;Gene Expression;gene network;Genes;Genetic;genetic element;Genetic Transcription;Genome;genome-wide;Genomic approach;genomic locus;Genomics;Goals;histone modification;Human;Human Genome;human induced pluripotent stem cells;improved;induced pluripotent stem cell;interest;knock-down;Length;Link;loss of function;Mediating;Messenger RNA;Mobile Genetic Elements;Modification;Molecular;Mouse Embryonic Stem Cells;Nerve Degeneration;Neurodegenerative Disorders;Neuronal Differentiation;neuronal survival;Neurons;Nuclear;Pathologic;Pathology;Pathway interactions;Patients;Play;pluripotent stem cell differentiation;Point Mutation;Process;protein TDP-43;Regulation;Relaxation;Reporting;Research Project Grants;Retroelements;Retrotransposition;Retrotransposon;Reverse Transcriptase Inhibitors;Reverse Transcription;RNA;RNA Decay;RNA Degradation;RNA metabolism;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Site;Techniques;therapy development;Tissues;Transcript;Transcriptional Activation;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegeneration


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Chiral N-heterocycles are imperative scaffolds found in pharmaceuticals and biological processes. Our research program focuses on the development of novel methods for the economical and selective synthesis of such axially chiral N-heterocyclic compounds using small amounts of deliberately designed catalyst. Therefore, it is expected that the proposed research will have a significant impact on synthetic methodology and human healthcare.

PI_NAMEs: YAN, YONG  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Light-Induced Atroposelective N-Heterocyclization via Chiral Perovskite Nanocrystals


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Infectious Diseases;Kidney Disease;Lung;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Acute lung injury in the intensive care unit has a high mortality and is worsened by acute kidney injury. The mechanisms behind the kidney-lung interaction are not well understood and have potential as therapeutic targets to improve patient outcomes. The proposed project studies how activation of the intracellular innate immune receptor NOD2 contributes to acute lung injury following acute kidney injury.

PI_NAMEs: DEWOLF, SEAN EDWARD (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute Lung Injury;Acute Renal Failure with Renal Papillary Necrosis;Acute Respiratory Distress Syndrome;Alveolar;Binding;career;cell injury;cell type;Cells;Cellular biology;Clinical;clinical training;cytokine;Cytoplasm;Data;Development;Edema;effective therapy;Endothelial Cells;Endothelium;Environment;Epithelial Cells;Event;experimental study;Exposure to;Family;Family member;Foundations;Funding;Future;Gases;Grant;Hospitalization;Human;Immune;Immune response;Immune signaling;Immunologic Receptors;improved;in vivo;in vivo Model;Inflammation;Inflammatory;Inflammatory Response;Injury;Injury to Kidney;innate immune mechanisms;innate immune pathways;Intensive Care Units;interest;K-Series Research Career Programs;Kidney;Knock-out;Knowledge;Laboratories;Link;Lung;lung injury;lung microvascular endothelial cells;MAP Kinase Gene;Membrane;Mentors;Modeling;Molecular;Molecular Biology;mortality;mouse model;Mus;Natural Immunity;Necrosis;novel therapeutic intervention;Nucleotides;pathogen;Pathogenesis;pathogenic microbe;Patient-Focused Outcomes;Patients;Pattern;Pattern recognition receptor;Permeability;pharmacologic;Physicians;Play;Production;receptor;renal ischemia;Renal tubule structure;Reperfusion Injury;Research Institute;response;Role;Scientist;Serum;Signal Pathway;Signal Transduction;skills;Stress;Techniques;Testing;Therapeutic;therapeutic target;Time;Training;Tubular formation;Up-Regulation;Vascular Endothelial Cell;Ventilator;Work

PROJECT_TITLE: Role of NOD2 in Acute Lung Injury Following Ischemic Kidney Injury


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project Narrative  To fundamentally uncover the regulatory mechanisms between animal genomes and TEs in neurodegenerative disorders, we are deploying genetics, genomics, biochemical and small RNA analytical approaches on the RNAi pathway in the Drosophila model system to complement the translational objective of characterizing the TE RNA regulation process in human cells and brain samples. TE activation during aging is an intriguing hypothesis behind neurodegeneration because all animal genomes harbor a major reservoir of active TEs that are latent when animals are young but are activated during aging. This study leverages our lab’s previously established investigations of TE regulation during Drosophila aging, and we will bring new insight into how human TE RNAs are also processed into small RNAs during human aging and how these TE small RNA levels are affected in diseased states.

PI_NAMEs: LAU, NELSON C (contact)

PROJECT_TERMS: Adolescent;Adult;Affect;aged;Aging;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;Animals;ATAC-seq;Atlases;Biochemical;Biological;Biological Models;Brain;Brain region;Cell Aging;Cells;Chromatin;cohort;Complement;Data Set;Development;Disease;disease phenotype;DNA Sequence Alteration;DNA Transposable Elements;Drosophila genus;Event;Feedback;frontal lobe;Functional disorder;Gene Mutation;gene therapy;Genetic;genetic approach;genetic testing;Genetic Transcription;Genome;Genome Mappings;Genome Stability;genome-wide;Genomic approach;genomic RNA;Genomics;Goals;Heterochromatin;Human;Human Cell Line;Human Genome;Huntington Disease;Individual;Infant;Infiltration;insight;Investigation;juvenile animal;knock-down;Link;Measures;MicroRNAs;Nerve Degeneration;Neurodegenerative Disorders;Neurons;new technology;Parasites;Parkinson Disease;Pathway interactions;Patients;Pattern;posttranscriptional;preservation;Process;protein TDP-43;Regulation;Retrotransposon;RNA;RNA Interference;RNA Interference Pathway;RNA Processing;Sampling;Small RNA;System;tau expression;Testing;Transcript;transcriptome;transcriptomics;Transgenic Organisms;translational study

PROJECT_TITLE: Transposable Element (TE) RNA regulation via small RNA pathways in aging cells and neurodegeneration.


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Immunotherapy;Infectious Diseases;Lupus;Rheumatoid Arthritis

ORG_CITY: SUNNYVALE

ORG_NAME: LARIX BIOSCIENCE, LLC

PHR: Narrative  As a group, autoimmune diseases impose a major health burden. While specific autoimmune diseases are infrequent in the population, in the aggregate they affect 5-8% of Americans and can be life-threatening. Current treatments are only moderately effective, and carry a heavy risk of adverse effects. We have identified a monoclonal antibody specific for B cells that shows efficacy in animal models of rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes. This antibody therapy is safer than competing approaches because it does not induce B cell depletion and its effects can be reversed by cessation of treatment, enabling restoration of immune function. With further molecular improvements and clinical development, this antibody will greatly expand the therapeutic options for SLE and other autoimmune diseases.

PI_NAMEs: CAMBIER, JOHN C;LARRICK, JAMES W;MENDELSOHN, ANDREW R (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Adverse effects;Affect;Affinity;Agonist;American;anergy;Animal Model;Animals;anti-CD20;Antibodies;Antibody Formation;Antibody Therapy;Antigen Receptors;Antigen-Antibody Complex;Antigens;Arthritis;Attenuated;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoinflammatory;autoreactivity;B cell therapy;B-Cell Antigen Receptor;B-Lymphocytes;belimumab;CD72 gene;Cells;checkpoint receptors;Chronic;clinical development;Collagen Arthritis;Colorado;COVID-19;Data;Daughter;Development;Disease;Disulfides;Dose;Emerging infection;emerging pathogen;exhaustion;Experimental Autoimmune Encephalomyelitis;Extracellular Domain;Formulation;Frequencies;Generations;Health;Human;immune function;immune modulating agents;Immunity;Immunotherapy;improved;In Vitro;in vivo;Inflammation;Injections;Insulin-Dependent Diabetes Mellitus;Integral Membrane Protein;ITAM;Knock-in Mouse;Latent virus infection phase;Lead;Life;Link;Mediating;medical schools;Modeling;Molecular;Monkeypox;Monoclonal Antibodies;mouse model;Multiple Sclerosis;Mus;Mutation;next generation;novel;NR0B2 gene;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;PIK3CG gene;Plasma Cells;Plasmablast;Poliomyelitis;Population;prevent;Pristane;Production;professor;PTEN gene;reactivation from latency;Receptor Aggregation;response;restoration;Rheumatoid Arthritis;Risk;rituximab;Safety;sample fixation;Signal Transduction;Source;src-Family Kinases;Surface;System;Systemic Lupus Erythematosus;Systemic Therapy;T-Lymphocyte;Therapeutic;therapeutic candidate;Therapeutic Uses;Time;Tissues;Transducers;Transgenic Organisms;Tyrosine;unvaccinated;Withholding Treatment;Work

PROJECT_TITLE: Silencing autoantibody secretion for SLE therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(10)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative RNA expression from retrotransposable elements (RTEs) is enhanced in Alzheimer’s disease (AD). The proposed research aims to better understand the functional roles of RTE-derived RNA and the regulatory mechanisms that lead to their aberrant expression in AD. This work will provide mechanistic basis for how and which RTEs may contribute to AD, potentially informing development of novel diagnostic and therapeutic strategies in the future.

PI_NAMEs: XIAO, XINSHU GRACE (contact)

PROJECT_TERMS: ADAR1;Adenosine;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Autopsy;Brain;brain control;Cell Culture Techniques;Cell Differentiation process;Cells;crosslinking and immunoprecipitation sequencing;Data;Development;Disease;Double-Stranded RNA;ds RNA-Binding Proteins;Elements;Enzymes;experimental study;Family;Future;Gene Expression;Genes;Genetic Transcription;Genomics;Goals;Human;human disease;Human Genome;immunogenicity;inflammatory marker;Inosine;insight;Interferon Type I;Interferons;Link;Location;Mediating;Modeling;Natural Immunity;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;Neurons;novel diagnostics;novel therapeutic intervention;Nuclear;Paste substance;Pathogenesis;Phenotype;Physiological;Production;Protein Isoforms;protein TDP-43;Proteins;Publishing;Regulation;Repetitive Sequence;Research;response;RNA;RNA Editing;RNA-Binding Proteins;Role;Sampling;sensor;Structure;Subgroup;tau Proteins;Testing;Tissues;Transcript;transcriptome sequencing;Up-Regulation;Work

PROJECT_TITLE: Regulation and function of dsRNAs derived from retrotransposable elements in AD


NIH_SPENDING_CATS: Cancer;Hematology;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative This proposal analyzes the cellular and molecular mechanisms that regulate hematopoietic stem cell (HSC) transplant and hematopoietic regeneration following myelosuppression. Improving our understanding of how HSC transplant and regeneration occur at the molecular level is highly relevant to the treatment of patients with immune disorders, bone marrow failure syndromes, and leukemias. Furthermore, the identification and analysis of regenerative factors that promote hematopoietic recovery following injury is also necessary to support hematopoietic recovery in patients that experience accidental radiation exposure.

PI_NAMEs: TERMINI, CHRISTINA MARIE (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Address;Adult;Advisory Committees;Anemia;Award;Biological Assay;Biology;Blood;Blood Vessels;bone marrow failure syndrome;career;career development;Cell Count;cell growth;Cell Maintenance;Cell Proliferation;cell regeneration;Cells;Cellular biology;Chemotherapy and/or radiation;Clinical;curative treatments;Data;differential expression;Dose;educational atmosphere;Endothelium;Engraftment;Equilibrium;experience;experimental study;Faculty;fibroglycan;genetic signature;Glycobiology;Goals;Grant;Growth Factor;Hematopoiesis;Hematopoietic;hematopoietic stem cell niche;hematopoietic stem cell quiescence;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;hematopoietic tissue;Heparan Sulfate Proteoglycan;Heparitin Sulfate;Homeostasis;Human;Image;Immune system;Immune System Diseases;Immunodeficient Mouse;improved;in vivo;in vivo Model;Individual;Infrastructure;Injury;injury recovery;Institution;Integral Membrane Protein;International;Knockout Mice;Knowledge;Laboratories;Lead;Leadership;leukemia;Lymphoma;Malignant Neoplasms;Measures;Mediating;Mediation;Medical;Mentors;Mentorship;Microscopy;Modeling;Molecular;Molecular Analysis;Mus;mutant;Mutation;Myelosuppression;Natural regeneration;Organism;Pain;Patients;Phase;Polysaccharides;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;preservation;Process;professor;programs;Proteoglycan;Public Health;Radiation Accidents;Radiation exposure;Radiation Injuries;radiation recovery;Radiation therapy;Recovery;regeneration following injury;regenerative;Regulation;repaired;Research;research and development;research facility;Resource Development;Role;self-renewal;Signal Transduction;skills;Source;stem cell biology;stem cell engraftment;stem cell exhaustion;stem cells;Stress;Structure;success;Surface;symposium;Testing;Therapeutic;Tissues;Training;transcriptome sequencing;translational applications;translational model;Transplantation;Treatment Protocols;Umbilical Cord Blood;Work;Writing;Xenograft procedure

PROJECT_TITLE: The role of Syndecan-2 in hematopoietic stem cell maintenance and regeneration

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE This project seeks to investigate relationships between multiple aspects of cannabis use in relation to HIV prevention behaviors (e.g., pre-exposure prophylaxis [PrEP] use, adherence, and discontinuation) and (biological vulnerability to HIV infection) among Black gay, bisexual and other men who have sex with men (MSM), a population in the United States heavily impacted by HIV/AIDS.

PI_NAMEs: DUNCAN, DUSTIN T (contact);KNOX, JUSTIN

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Adherence;AIDS prevention;Alcohols;Awareness;Behavior;biobehavior;Biological;Biological Markers;Bisexual;black men who have sex with men;Black race;Cannabis;Characteristics;Chicago;Cognitive;cohort;Cohort Studies;COVID-19;COVID-19 pandemic;cytokine;Data;Disparity;Drug usage;Ecological momentary assessment;Enrollment;Environment;Epidemic;Epidemiology;Equity;Event;Face;Funding;Gays;health inequalities;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;HIV/STD;Immune;immune function;Immunology;Incidence;Individual;Inflammation;Infrastructure;innovation;Intervention;Knowledge;Legal;Link;marijuana use;Measures;Mediating;Mediator;men;men who have sex with men;Methods;Neighborhoods;Outcome;Participant;Pharmaceutical Preparations;Plasma;Policies;polysubstance use;Population;Populations at Risk;pre-exposure prophylaxis;Prevention;Prospective, cohort study;Public Health;racial minority population;Rectum;Reporting;Research;response;Risk;Role;Sex Behavior;sexual minority group;sexual risk behavior;Shelter facility;social;Social Network;Stimulant;substance use;Surveys;Technology;therapy development;transmission process;Typology;United States;United States National Institutes of Health;uptake;Visit

PROJECT_TITLE: Cannabis use, PrEP and HIV transmission risk Among Black MSM in Chicago


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Digestive Diseases;Nutrition;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: There is a critical shortage of investigators in pediatric gastroenterology who can advance new knowledge to improve the outcomes for children with digestive diseases. Our training program focuses on: 1) Liver Disease and Modeling, 2) Digestive Disease and Immunity, 3) Digestive Disease and Obesity, and 4) Translation Embryology. We will provide mentored training to pediatricians who will become the next generation of investigators and academic leaders in pediatric gastroenterology.

PI_NAMEs: DENSON, LEE ARMISTEAD (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TITLE: Pediatric Gastroenterology and Nutrition Training Grant


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Genetics;Hearing Loss;Human Genome;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

PHR: Relevance This study builds on new research into the functional significance of neuronal cell types in the mammalian cochlear nucleus, the first station for auditory processing. The results are essential for eventually understanding how the brain changes following injury or disease that affects hearing. This is important as such brain changes can affect speech processing and the effectiveness of hearing devices like hearing aids and cochlear implants.

PI_NAMEs: TRUSSELL, LAURENCE O (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Acoustic Nerve;Address;Affect;Age;Aging;Anatomy;Auditory;auditory processing;Auditory system;Axon;Back;Brain;Brain Stem;Categories;cell type;Cells;Cochlear Implants;Cochlear nucleus;Complex;Data;Development;Devices;digital;Dimensions;Disease;Disinhibition;Dyes;Effectiveness;Electrophysiology (science);excitatory neuron;Fiber;Fluorescent in Situ Hybridization;Foundations;Frequencies;Fruit;Fusiform Cell;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic Transcription;Hearing;Hearing Aids;hearing impairment;Hearing problem;Heterogeneity;In Vitro;in vivo;Individual;inhibitory neuron;Inhibitory Synapse;Injury;insight;Interneurons;Location;Maps;Methods;Molecular;Molecular Genetics;Molecular Profiling;Monitor;Mus;Neuromodulator;Neurons;novel;Nuclear;optogenetics;parallel processing;patch clamp;patch sequencing;Patch-Clamp Techniques;Pathway interactions;Phase;Physiological;Physiology;Population;Property;Research;Resolution;response;Sensory;Signal Transduction;single nucleus RNA-sequencing;Slice;sound;speech processing;Speed;stellate cell;Synapses;Theoretical Studies;tool;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Synaptic Mechanisms in the Auditory System

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Wound Healing and Care

ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative In response to a wound, some cells fuse with several of their neighbors to become giant cells, which move faster and close wounds faster than regular cells. Similar giant cells are observed in many types of cancers, where they are malignant and resistant to therapy. We will investigate how these giant cells form in response to wounds, how they function in wound repair, and how they are eliminated after a wound is closed.

PI_NAMEs: HUTSON, M. SHANE;PAGE-MCCAW, ANDREA  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Ablation;Acceleration;Actins;Apoptosis;Attention;Basic Science;Behavior;Biological Models;Biology;Calcium;cancer cell;cancer therapy;cancer type;Carcinoma;Cell fusion;cell injury;Cell membrane;cell motility;cell type;Cells;Cessation of life;clinically relevant;Detection;Development;Diploid Cells;Diploidy;Drosophila genus;epithelial repair;Epithelium;Experimental Models;Foundations;Funding;Genes;Giant Cells;Image;innovation;Intercalated Cell;Investigation;Knowledge;Lasers;live cell imaging;Malignant - descriptor;Malignant Neoplasms;Maps;Mediating;Membrane;Modeling;monolayer;Mononuclear;multidisciplinary;Neoplasm Metastasis;neoplastic cell;Organism;Participant;Polyploid Cells;Polyploidy;Process;Recurrence;Relapse;repaired;Resistance;response;Role;seal;Signal Transduction;Source;Stress;System;Testing;therapy resistant;tissue repair;Tissues;tumor;Virus Diseases;wound;wound closure;wound healing;wound treatment

PROJECT_TITLE: Cell fusion and the role of syncytia in the response to epithelial damage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(80)S]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Bridge2AI: a FAIR AI BRIDGE Center (FABRIC) Overall Narrative We will organize the Bridge to AI Consortium by integrating the work of six major teams working on administration, team science, ethics, standards, tools and training. These teams will interact with those of data generation projects to accelerate AI research related to human health.

PI_NAMEs: OHNO-MACHADO, LUCILA  (contact)

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Acceleration;Adherence;Affect;Agreement;Anthropology;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Big Data to Knowledge;Biomedical Research;blockchain;Bridge to Artificial Intelligence;California;Catalogs;cloud based;Collaborations;Communities;Computer software;Data;data access;design;digital;Educational Activities;Educational Materials;effectiveness evaluation;Ensure;Environment;ethical, legal, and social implication;Ethics;Evaluation;experience;FAIR principles;Funding;Generations;Goals;Guidelines;Health;Human;Humanities;indexing;Individual;innovation;Institution;Learning;Life Cycle Stages;Logistics;Measures;Metadata;novel;outreach;Participant;Persons;Policies;Privacy;privacy preservation;Problem behavior;Process;programs;Psychology;Research;Research Personnel;responsible artificial intelligence;Science;Series;skill acquisition;Social Sciences;software development;Standardization;Structure;Technology;Texas;Thinness;tool;Training;Training Activity;United States National Institutes of Health;Universities;Vision;Work;Workforce Development

PROJECT_TITLE: A FAIR Bridge2AI Center (FABRIC)


ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE We recently discovered that the enzyme Glutamate Carboxypeptidase II (GCPII) is highly upregulated in activated macrophages infiltrating muscle during aging, and that inhibiting the elevated GCPII activity dramatically delays neuromuscular junction (NMJ) denervation, muscle function and muscle volume loss in aged mice. Unfortunately, there are no clinically available GCPII inhibitors as current inhibitors are polar and charged at physiological pH resulting in poor oral bioavailability and limited tissue penetration. Given its significant clinical potential, we propose to utilize a hydroxyl-dendrimer delivery system to provide sustained and targeted delivery of GCPII inhibitors to activated muscle macrophage; successful execution will result in an oral dendrimer-GCPII inhibitor conjugate ready for clinical translation to combat age-related sarcopenia.

PI_NAMEs: HOKE, AHMET ;RANGARAMANUJAM, KANNAN ;SLUSHER, BARBARA STAUCH (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acids;Address;Adult;Affect;age related;age-related muscle loss;Aging;Animal Model;Animals;Autopsy;Behavioral;Biodistribution;Biological Assay;Biological Availability;Body Weight;Cells;Charge;Chronic;Circulation;Clinical;Clinical Chemistry;Clinical Research;clinical translation;Clinical Trials;combat;cyanine dye 5;Dendrimers;Denervation;Development;Diameter;Disease;Dose;Drug Kinetics;Economic Burden;effective therapy;efficacy evaluation;Electromyography;Electrophysiology (science);Enzymes;experience;falls;Fiber;FOLH1 gene;Fracture;fracture risk;Future;Generations;glutamatergic signaling;Glutamates;Half-Life;hallmarks of aging;Hand Strength;Health Care Costs;Histologic;Hospitalization;Human;Hydrolysis;Hydroxyl Radical;Immune;in vivo;Infiltration;Inflammation;Inflammatory;inhibitor;Injury;Kinetics;Label;Link;Liquid substance;Locomotion;Macrophage;Magnetic Resonance Imaging;Maintenance;Measures;Microglia;mortality;Mus;Muscle;muscle aging;muscle form;Muscle function;N-acetylaspartylglutamate;nanoparticle;nerve supply;Neuromuscular Diseases;Neuromuscular Junction;Neuropeptides;Neurotransmitters;old mice;Oral;Pathologic;Patients;Penetration;Phagocytes;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Physical Function;Physiological;Plasma;Population;Prevention;Process;Risk;sarcopenia;severe COVID-19;small molecule;Source;Stains;Stomach;Surface;System;targeted delivery;Testing;Tissues;translational approach;transmission process;Weight

PROJECT_TITLE: Macrophage-targeted dendrimer 2-PMPA for the treatment of age-related sarcopenia

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS-R]


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Acceleration;Address;Advisory Committees;Agreement;Behavioral Research;Biomedical Research;blockchain;Bridge to Artificial Intelligence;Code;Communication;Communities;Computer software;Contracts;Creativeness;Data;data access;data integration;data sharing;Decentralization;Dependence;design;digital;distributed ledger;Educational Materials;Ensure;Ethics;Evaluation;experience;FAIR principles;Generations;Goals;Guidelines;Health;Hearing;Individual;innovation;Institution;Intellectual Property;interest;Logistics;meetings;member;Methods;Modeling;Monitor;National Human Genome Research Institute;Online Systems;organizational structure;outreach;Peer Review;Performance;Persons;Policies;Process;programs;prospective;Protocols documentation;Publications;Records;Reporting;Research;Research Personnel;Resource Sharing;Resources;Review Literature;skill acquisition;social media;Standardization;Structure;symposium;synergism;Technology;Texas;timeline;tool;Training;United States National Institutes of Health;Universities;Vision;Voice;web portal;web site;Work;Workforce Development;working group

PROJECT_TITLE: Admin Core (FABRIC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-K]


PI_NAMEs: MALIN, BRADLEY A. (contact)

PROJECT_TERMS: Address;adverse outcome;Algorithms;Area;Artificial Intelligence;Behavioral Research;Benefits and Risks;Big Data;Bioethics;Biomedical Research;Bridge to Artificial Intelligence;Catalogs;Climacteric;Clinical;clinical decision-making;Collaborations;Collection;Communities;community engagement;Consent;Core Assembly;Data;Data Collection;data management;Data Protection;Data Set;decision making algorithm;Development;digital health;digital tool;distrust;Economics;Ensure;Environment;Equity;Ethical Issues;Ethics;European;experience;Foundations;Future;Generations;Guidelines;health care delivery;Healthcare;Human;human centered design;implementation science;improved;Individual;Informatics;Infrastructure;interdisciplinary approach;Knowledge;Laws;Learning;learning community;legal implication;Literature;Machine Learning;Medicine;multidisciplinary;Needs Assessment;outreach;Persons;prevent;Privacy;privacy protection;Process;programs;Public Policy;Public Relations;racial bias;Regulation;Research;Research Ethics;response;responsible artificial intelligence;Rights;Running;scaffold;social;Societies;success;Surveys;Sustainable Development;symposium;Technology;technology development;Time;tool;Trust;trustworthiness;Unconscious State;usability;Vision;willingness;Work;World Health Organization

PROJECT_TITLE: Ethics Core (FABRIC)


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Neurodegenerative;Neurosciences;Rare Diseases;Transmissible Spongiform Encephalopathy (TSE)

ORG_CITY: FORT COLLINS

ORG_NAME: COLORADO STATE UNIVERSITY

PHR: Project Narrative Prions cause epidemics in animals and humans and, like viruses, evolve to produce novel strains with unpredictable properties. Prions are misfolded versions of a host-encoded protein which contain the necessary and sufficient information for infectious propagation within their conformation, thus obviating requirements for agent-encoded genomic material. This proposal addresses important emerging issues relating to novel animal prion strains, their potential to wreak significant ecological and economic havoc, and the increasingly uncertain prospect that they might cause disease in humans.

PI_NAMEs: TELLING, GLENN C (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Address;Animals;Biochemical;Biological;Cells;Central Nervous System;cervid;Chronic Wasting Disease;Dedications;design;Development;Disease;Economics;Epidemic;Evolution;flexibility;Funding;Funding Mechanisms;Genomics;Goals;Human;improved;In Vitro;innovation;Mentors;Molecular Conformation;Molecular Genetics;National Institute of Neurological Disorders and Stroke;next generation;novel;Output;Peripheral;Phenotype;Play;Prevalence;prevent;Prion Diseases;Prions;Property;Proteins;PrP;Recurrence;Research;Research Personnel;Research Project Grants;Resolution;Resources;Risk;Role;Senior Scientist;success;Supervision;Transgenic Organisms;transmission process;United States National Institutes of Health;Virus;Zoonoses

PROJECT_TITLE: Maximizing research success in studies of naturally-occurring prion diseases


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

PHR: HIV infects cells by entering the nucleus and integrating its reverse transcribed DNA into host genome. Currently, key steps of infection, including disassembly of the protective capsid shell surrounding the viral DNA and subsequent events leading to integration, are not well understood. We will employ a panel of biochemistry, virology, and single virus imaging techniques to delineate the controversial capsid disassembly process and characterize the role of new nuclear host factors required for infection.

PI_NAMEs: KVARATSKHELIA, MAMUKA ;MELIKIAN, GREGORY B (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Amino Acids;Anti-viral Agents;base;Binding;Biochemical;Biochemistry;Biological Assay;Biophysics;Capsid;Capsid Proteins;Cell fusion;Cell Nucleus;Cells;Complex;Cytoplasm;Data;DNA;DNA Integration;Dyes;Electron Microscopy;Event;Exclusion;experimental study;Genetic Transcription;Genome;HIV;HIV-1;Image;Imaging Device;Imaging Techniques;Imaging technology;In Vitro;Infection;Innate Immune Response;Integrase;Integration Host Factors;integration site;knock-down;Knowledge;Label;Light;live cell imaging;Location;Macromolecular Complexes;Maps;Mass Spectrum Analysis;Microscopy;minimally invasive;Modeling;novel;novel strategies;novel virus;Nuclear;Nuclear Import;Nuclear Pore;nucleocytoplasmic transport;Permeability;Process;Productivity;Proteins;Recombinants;recruit;Regulation;Reporting;Reverse Transcription;Ribonucleoproteins;Role;Site;stem;structural biology;Techniques;Technology;transcriptional coactivator p75;Travel;Tube;Validation;Viral;viral DNA;viral RNA;virology;Virus;Visualization

PROJECT_TITLE: Imaging early steps of HIV-1 infection and virus-host factor interactions

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Different contexts require different strategies for incorporating time-related information into value-based decisions. The goal of this project is to improve the precision with which we can measure human brain processes that support context-appropriate calibration of valuation and decision processes. The results will advance our understanding of the basis of miscalibrated decision behavior in mental health conditions— including both failures to persist toward long-run goals and unwarranted persistence toward non-beneficial outcomes—and will lead to new computational tools for studying the relevant brain systems.

PI_NAMEs: MCGUIRE, JOSEPH T. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: The Role of Medial Prefrontal Cortex in Context-Dependent Valuation and Decision Processes

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Aging;Autoimmune Disease;Brain Disorders;Disability Research;Genetics;Multiple Sclerosis;Neurodegenerative;Neurosciences;Women's Health Research

ORG_DEPT: NEUROLOGY

PHR: The greatest unmet need in multiple sclerosis (MS) is to develop novel treatments targeting cells and processes within the central nervous system (CNS) to confer neuroprotection and repair disabilities, in not only relapsing remitting MS, but also in secondary progressive MS. A “one size fits all” neuroprotective treatment approach in MS will not work, since 1) MS patients are heterogenous regarding which disabilities are predominant, 2) being female versus male impacts rates of disability progression, and 3) aging corresponds with disability progression. This R35 will use a cell-specific, region-specific, and sex-specific approach to discover neurodegenerative targets optimized for each disability in MS models in females and males during young adulthood and aging.

PI_NAMEs: VOSKUHL, RHONDA R (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Age;age effect;Aging;Astrocytes;Atrophic;Autoimmune;Autopsy;axon injury;Back;bench to bedside;Brain;Brain region;Cell Communication;cell type;Cells;Central Nervous System;Clinic;Clinical;Cognition;conditional knockout;Data;Demyelinations;Development;differential expression;disability;disability impact;Experimental Autoimmune Encephalomyelitis;Female;Four Core Genotypes;Gene Expression;Genes;Genetic;glial activation;Gonadal Steroid Hormones;Hormones;Human;Immune system;Immunohistochemistry;in vivo;Inflammation;interest;Intervention;knock-down;Label;Lifelong disability;Magnetic Resonance Imaging;male;men;Microglia;Modeling;Multiple Sclerosis;multiple sclerosis patient;Mus;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuropathology;neuroprotection;novel;novel strategies;old mice;Oligodendroglia;optimal treatments;Pathway interactions;pharmacologic;Pharmacological Treatment;Phenotype;Placebos;pre-clinical;pre-clinical research;Process;Relapse;Relapsing-Remitting Multiple Sclerosis;repaired;Research;Secondary Progressive Multiple Sclerosis;sex;Sex Chromosomes;Sex Differences;single nucleus RNA-sequencing;success;Synapses;Tissues;transcriptome sequencing;transcriptomics;Translating;trial design;Validation;Vision;Walking;Woman;women versus men;young adult

PROJECT_TITLE: Neurodegeneration Underlying Distinct Disabilities in Multiple Sclerosis Using a Cell-Specific, Region-Specific, and Sex-Specific Approach


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: MAYWOOD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative The healthy corneal surface is an effective barrier to bacteria, yet the bacterial pathogen Pseudomonas aeruginosa is able to infect the eye during contact lens wear. We discovered that corneal epithelial cells normally undergo pyroptosis, an inflammatory and lytic programmed cell death, in response to bacterial invasion; however, P. aeruginosa inhibits this host response with one of its toxins, Exotoxin S. We will investigate the importance of pyroptosis in resolving microbial encounters at the ocular surface, and also identify how P. aeruginosa is able to subvert this host defense mechanism.

PI_NAMEs: KROKEN, ABBY R (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: ADP Ribose Transferases;ADP ribosylation;Apoptosis;Bacteria;Bypass;Caspase;Cell Line;cell type;Cells;Cessation of life;Cicatrix;Clinical;Contact Lenses;Cornea;corneal epithelium;Corneal Opacity;Corneal Stroma;CRISPR/Cas technology;Cultured Cells;cytokine;Cytoplasm;Cytoprotection;Data;Defense Mechanisms;Epithelial Cells;Epithelium;Exotoxins;experimental study;Eye;Eye Infections;Film;Hela Cells;Host Defense;Host Defense Mechanism;Hydrophilic Contact Lenses;Image;imaging modality;Immune;Immune response;Infection;Inflammasome;Inflammatory;Injections;Interleukin-1 beta;Invaded;Keratitis;Knockout Mice;Life Style;Link;Lipopolysaccharides;Lytic;Measures;Mediating;Microbe;microbial;Modeling;Molecular;Monitor;mouse model;Mus;mutant;Neutrophil Infiltration;novel;ocular surface;Outcome;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Predisposition;prevent;Process;Production;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Publications;recruit;Resolution;response;Role;Site;Surface;Testing;Time;Tissues;Toxin;Transformed Cell Line;Virulence Factors;Vision;Wild Type Mouse

PROJECT_TITLE: Inflammasome-mediated corneal epithelial cell defenses inhibited by pathogenic bacteria

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: Aging;Bioengineering;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposal focuses on harnessing the osteoanabolic function of adenosine signaling to promote bone tissue repair in older adults. Successful completion of the proposed study will lead to a new therapeutic strategy to treat critical bone fractures and complications associated with bone diseases.

PI_NAMEs: VARGHESE, SHYNI  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acceleration;Acids;active lifestyle;Address;Adenosine;Adjuvant;ADORA2A gene;Age;age related;Aging;angiogenesis;animal old age;Behavior;Biocompatible Materials;BMP2 gene;bone;bone aging;Bone callus;Bone Diseases;bone fracture repair;bone healing;bone health;Bone Injury;bone quality;Bone Regeneration;Bone Tissue;Bone Transplantation;CD8-Positive T-Lymphocytes;Cells;Circulation;Clinical;cost;cost effective;crosslink;Cyclic AMP;cytokine;Defect;Development;Dose;Economic Burden;efficacy evaluation;Environment;extracellular;Femur;Flow Cytometry;Fracture;fragility fracture;Functional disorder;Gait;Gel;Gene Expression;Half-Life;healing;Histologic;Hyaluronic Acid;Immune;Immune response;immunoregulation;Impaired healing;Implant;improved;In Situ;Injectable;Injury;juvenile animal;Knock-out;laser capture microdissection;Literature;longitudinal analysis;Macrophage;Matrix Metalloproteinases;Mechanics;Modeling;Natural regeneration;Nature;neutrophil;novel therapeutic intervention;old mice;older adult;older patient;Osteogenesis;Osteoporosis;Patients;peripheral blood;Phosphorylation;Plasma;Play;Population;Prevalence;Public Health;Purinergic P1 Receptors;Quality of life;Receptor Signaling;regenerative;Regulatory T-Lymphocyte;Rejuvenation;repaired;Research;Role;scaffold;sex;Signal Transduction;single-cell RNA sequencing;Site;Sorting;spatiotemporal;success;T-Lymphocyte;Testing;Therapeutic;Tibial Fractures;tissue regeneration;tissue repair;Tissues;Trauma;Vascularization;Wild Type Mouse

PROJECT_TITLE: Localization of adenosine to promote fracture healing

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Microbiome;Nutrition;Prevention

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Targeted manipulation of the gut microbiota to increase health-associated features and functions is a sought- after therapeutic strategy for many human conditions and diseases. This proposed research seeks to identify mechanisms by which cell surface polysaccharides from human gut bacterial strains shape microbiota composition and function through utilization as a nutrient source by microbiota members and by modulating the immune system. The knowledge generated from this study will improve our understanding of the nutritional landscape within the gut, and identify specific carbohydrate structures useful for targeted microbiota interventions.

PI_NAMEs: WESENER, DARRYL A (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Award;Bacteria;bacterial community;bacterial genome sequencing;Bacterial Polysaccharides;Bacterial RNA;Bacteroides;Binding Proteins;Bioinformatics;Biological;Biological Assay;Biological Process;Biosensor;carbohydrate structure;Carbohydrates;Carbon;career development;Cell surface;Chemistry;combinatorial;Communities;Consumption;Data Analyses;Development;Diet;Dietary Fiber;Dietary Polysaccharide;Dietary Supplementation;dietary supplements;Disease;Educational process of instructing;Environment;experimental study;extracellular;Formulation;Fractionation;Genetic;Genetic Screening;Genome;genome annotation;Genomics;Glycobiology;Gnotobiotic;Goals;Grant;Growth;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;Health Promotion;Human;human model;Immune;Immune Evasion;immune function;Immune system;Immunoglobulins;immunoregulation;improved;In Situ;In Vitro;in vivo;innovation;Interdisciplinary Study;Intervention;Knowledge;Lead;Lectin;Libraries;Link;member;Mentors;Metabolic;Metabolism;Metagenomics;Methods;Microbe;microbial;microbial community;microbiota;microbiota composition;Microscopic;mouse model;Mus;Nutrient;Nutrient availability;Nutritional;Outcome;Phase;Phenotype;Plants;Polysaccharides;Positioning Attribute;Postdoctoral Fellow;prebiotics;probiotic supplementation;Probiotics;Proteins;Regulation;Research;Resistance;Series;Shapes;skills;small molecule;Source;Structure;Students;Supplementation;Systems Biology;Techniques;Testing;Therapeutic;therapeutic target;Training;transcriptome sequencing;Translating;Universities

PROJECT_TITLE: Human gut bacterial cell surface polysaccharides as a microbial nutrient source and target of immunoregulatory proteins shape gut microbiota structure and function


NIH_SPENDING_CATS: Aging;Genetics;Machine Learning and Artificial Intelligence

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: Project Narrative This project aims to develop a new tool to assess the overall health of a mouse and predict early in a mouse's life when it will die. This assessment will be an important tool for the aging research field to increase the efficiency of studies looking at interventions to delay aging.

PI_NAMEs: KANE, ALICE E (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Age;age acceleration;Age Months;age related;Age related pathologies;Aging;Attenuated;Award;Behavior;Behavioral;biological age;Biological Markers;Biology of Aging;Blood;C57BL/6 Mouse;Caloric Restriction;career;Cessation of life;Chromatin;Chronology;Clinical;clinically relevant;Collection;Complete Blood Count;Computer Models;Consumption;cost;cost effective;data integration;Detection;Development;differential expression;DNA;DNA Methylation;Electrocardiogram;Elements;epigenetic aging;epigenetic clock;Epigenetic Process;epigenome;Female;Fractionation;frailty;Gait;Goals;Health;health assessment;Health Status;healthspan;Heterogeneity;histone modification;Histones;Human;indexing;Individual;innovation;International;Intervention;Investigation;Kinetics;Life;life span;liquid chromatography mass spectrometry;Longevity;longitudinal analysis;Machine Learning;machine learning algorithm;machine learning model;male;Measures;medical schools;Mentors;Methodology;Methods;Methylation;Modeling;Molecular;Molecular Weight;mortality;mouse model;Mus;novel;old mice;Outcome;Outcome Measure;Peptides;Persons;Phase;Phenotype;Physiological;Plasma;Positioning Attribute;Postdoctoral Fellow;pre-clinical;Proteins;Reproducibility;Research;Research Personnel;Sampling;sex;Site;Skin Tissue;Statistical Models;Testing;Time;Tissues;tool;Training;Transgenic Organisms;Work

PROJECT_TITLE: Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic Determinants

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Overall Narrative Our objective is to understand fundamental mechanisms underlying communication between cancer cell genomic instability and the immune system. To achieve our goals, we have assembled three Projects that will work closely with three Cores to address critical questions on detection of genome instability in tumors by the immune response. Integration of these multidisciplinary projects with Mammalian Artificial Chromosome and Chemical Biology Cores will transform understanding of the molecular basis for immune detection of genome instability in cancer and define approaches to enhance immune therapy mediated responses in cancer.

PI_NAMEs: GREENBERG, ROGER A (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: 3-Dimensional;Acute;adaptive immune response;Address;Affect;Agreement;Aneuploidy;anti-tumor immune response;Architecture;arm;Artificial Mammalian Chromosomes;Basic Science;Biology;BRCA2 gene;cancer cell;Cancer Control;cancer immunotherapy;Cells;checkpoint inhibition;Chemicals;Chromosomal Instability;chromosome missegregation;Chromosome Segregation;Collaborations;Communication;Complex;Cytoplasm;Detection;DNA;DNA Damage;Double-Stranded RNA;Environment;Event;Gatekeeping;Gene Expression;Genomic Instability;Genomics;Goals;Immune;immune activation;immune checkpoint blockade;Immune response;Immune system;immunogenic;Immunotherapy;improved;in vivo;Inflammasome;Inflammatory;Innate Immune Response;Innate Immune System;Interferon Type I;Interferons;Ligands;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;mechanical force;Mechanical Stress;Mechanics;micronucleus;Mitosis;Mitotic;Modality;Molecular;multidisciplinary;mutant;neoplastic cell;Nuclear Envelope;Nucleic Acids;Pathway interactions;Patients;Pattern Recognition;Pattern recognition receptor;Phagocytes;Pre-Clinical Model;prevent;Process;Program Research Project Grants;Publishing;rational design;Reporting;Research;Research Personnel;response;RNA;sensor;Signal Transduction;Solid Neoplasm;Testing;Tissues;Treatment outcome;treatment response;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Viral;Work

PROJECT_TITLE: Genome Instability Induced Anti-Tumor Immune Responses


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Human Genome;Immunotherapy;Ovarian Cancer;Rare Diseases;Women's Health Research

PHR: Narrative This project proposal seeks to understand fundamental mechanisms of genome integrity control and their relationships to immune responses to cancer. We have demonstrated the importance of cell cycle checkpoints in mediating communication between DNA damage and innate immune responses, and now approach this central issue in cancer biology by utilizing unique systems to investigate DNA damage dependent (1) RNA pattern recognition, (2) signaling mechanisms that augment MDA5 and RIG-I activation and their impact on in vivo immune responses, and (3) communication between these mechanisms and NLRP9 dependent inflammasome activity in directing the tumor immune microenvironment. These pursuits will be performed in collaboration with other team members to define specific strategies that target the DNA damage response to elicit effective immune responses to cancer.

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Alleles;anti-tumor immune response;antiviral immunity;arm;Artificial Mammalian Chromosomes;Auxins;Biochemical;Biology;Black race;BRCA2 gene;Cancer Biology;cancer cell;Cancer cell line;Cancer Control;Cancer Etiology;cancer immunotherapy;Cancer Model;cancer therapy;Cell Cycle Checkpoint;Cells;Chemicals;Chromosomal Instability;chromosome missegregation;Collaborations;Communication;Coupled;Cytoplasm;Development;Dimerization;Distant Metastasis;DNA;DNA Damage;DNA Repair;DNA Repair Disorder;Double-Stranded RNA;Elements;fluorescence imaging;Functional disorder;Gene Expression;genome integrity;Genomic Instability;genotoxicity;Growth;homologous recombination;homologous recombination deficiency;Immune;immune activation;immune checkpoint blockade;Immune response;Immunocompetent;immunogenic;Immunosuppression;in vivo;Inflammasome;Inflammatory;Innate Immune Response;Interferons;Investigation;irradiation;Knowledge;Ligands;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;member;micronucleus;Mitosis;Mitotic;Modeling;Molecular;Mus;mutant;Mutation;neoplastic cell;novel strategies;Nucleic Acids;PARP inhibition;Pathway interactions;Pattern Recognition;Pattern recognition receptor;Preparation;Regulation;Reporting;response;RNA;RNA Helicase;RNA library;sensor;Serous;Signal Transduction;Stimulator of Interferon Genes;System;T-Lymphocyte;Testing;tool;TP53 gene;treatment response;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;ubiquitin-protein ligase

PROJECT_TITLE: Tumor cell instrinsic DNA damage signaling to the immune response


NIH_SPENDING_CATS: American Indian or Alaska Native;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE This proposal seeks to continue the successful holistic University of Utah Native American Research Internship program (NARI) to include summer research experiences in cardiovascular, pulmonary, and hematology (NHLBI). The NARI-NHLBI program will partner with researchers at the University of Utah with AI/AN undergraduates who aspire to help understand why AI/AN have been affected so disproportionately. The overarching goal of the NARI program is to increase the diversity of the U.S. biomedical science workforce and reduce health disparities in the AI/AN population by supporting the scientific development of each undergraduate NARI-NHLBI participant.

PI_NAMEs: HOLSTI, MAIJA  (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Address;Affect;African American population;Age;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;Asthma;Bachelor's Degree;Biomedical Research;Cardiovascular Diseases;Cardiovascular system;career;Cessation of life;Child Health;chronic liver disease;Cirrhosis;Clinical;Clinical Research;Clinical Skills;Collaborations;college;Communities;community engagement;Degree Completion;Development;Diabetes Mellitus;Disease;Doctor of Philosophy;Drops;Education;education research;effectiveness evaluation;ethnic minority population;experience;Family;Family member;Goals;graduate school;Health;health disparity;Healthcare;Hematological Disease;Hematology;higher education;Home;Infection;innovation;interest;Internships;Laboratories;Laboratory Research;Leadership;life span;Lung;Lung Diseases;Malignant Neoplasms;medical schools;Medicine;member;Mentors;Mentorship;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;Native Americans;native elder;Obesity;Outcome;Participant;peer;Pneumonia;poor health outcome;Positioning Attribute;Professional Education;programs;racial minority population;recruit;Reduce health disparities;Reporting;Research;Research Assistant;Research Personnel;Research Support;Risk Factors;Science;Scientist;Smoking;Students;Substance abuse problem;summer internship;summer research;Talents;Training;Trauma;tribal Nation;undergraduate student;underserved community;United States;Universities;Utah;Work

PROJECT_TITLE: Native American Short-Term Research Education Program in Children's Health


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Ovarian Cancer;Rare Diseases;Skin Cancer;Women's Health Research

PHR: Project Narrative – Project 2 Solid tumors evolve genetically, which for therapy makes them a diverse and moving target, and we hypothesize that extrinsic mechanical factors – particularly 3D tissue/tumor architecture and its rigidity – contribute in key ways to chromosome instability and to the immune-sculpted evolution of aneuploidy. Several new and diverse molecular tools will be used in solid tumor type microenvironments (rather than 2D) to clarify mechanisms by which adhesion pathways affect mitotic fidelity including DNA damage processes that extend to signaling pathways and innate immune responses. Pan-cancer patient data further indicates that high levels of aneuploidy skews macrophages and somehow impedes Tcell checkpoint blockade (in melanoma), but with new approaches and tools we have focused on macrophage checkpoint disruption that preliminary data shows (in challenging B16 melanoma models) can produce durable cures, which now requires understanding the contributions of aneuploidy and microenvironment.

PI_NAMEs: DISCHER, DENNIS E. (contact)

PROJECT_TERMS: 3-Dimensional;Actomyosin;Adhesions;Affect;Aneuploidy;antagonist;anti-tumor immune response;Architecture;Artificial Mammalian Chromosomes;Biology;Biophysics;Black race;cancer cell;cancer genome;Cancer Model;Cancer Patient;Carcinoma;CD47 gene;cell cortex;Cells;Chemicals;Chromosomal Instability;Chromosome Segregation;Clinical Trials;constriction;Coupled;Coupling;crosslink;Cytoplasm;Data;Dendritic Cells;DNA Damage;Equilibrium;Evolution;extracellular;Extracellular Matrix;Feedback;Genes;genetic payload;Genetic Variation;Genomic Instability;Human;Immune;immune checkpoint blockade;Immune signaling;Immunocompetent;Immunoglobulin G;Immunophenotyping;Impairment;In Vitro;in vivo;Inflammatory;Innate Immune Response;Integrin Binding;Integrins;Interferons;intraperitoneal;Kinetochores;Lead;Link;Liquid substance;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Mechanics;Melanoma;micronucleus;Microtubules;Mitosis;Mitotic;Mitotic spindle;Modeling;Molecular;Mus;mutant;Mutation;Myelogenous;Natural Immunity;Nature;neoplastic cell;novel;novel strategies;Oncogenes;optogenetics;Output;Pathway interactions;Peptides;Phagocytes;Population Heterogeneity;Process;Production;PTPNS1 gene;RNA;Role;segregation;Signal Pathway;Signal Transduction;single cell analysis;single cell genomics;Sister;Solid;Solid Neoplasm;subcutaneous;System;Testing;The Cancer Genome Atlas;Tissues;tool;tumor;Tumor Suppressor Genes;Tumor Tissue;Tumor-Associated Process;Variant;Visualization;whole genome

PROJECT_TITLE: Mechanics of Cells & Tissues impact Chromosome Instability & Phagocytic Interactions


NIH_SPENDING_CATS: Biotechnology;Wound Healing and Care

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our work focuses on understanding how inflammation resolves and tissues are repaired in the context of human health and disease. We aim to uncover mechanisms of cell migration within tissues, the signaling networks that regulate these processes and how they are integrated during wound healing. This work will impact our understanding and treatment of autoimmune disease, diabetic and other chronic wounds, cancer and immune deficiency disorders.

PI_NAMEs: HUTTENLOCHER, ANNA  (contact)

PROJECT_TERMS: Affinity Chromatography;Autoimmune Diseases;Autoimmunity;Award;Biological Models;Cardiovascular Diseases;Cell Communication;cell motility;cell type;Cells;chronic wound;Complex;Cues;Defect;design;Diabetes Mellitus;diabetic;Disease;Funding;Gene Expression;genetic manipulation;genome editing;Goals;Health;Human;human disease;Imaging Device;Immunologic Deficiency Syndromes;Inflammation;Investments;Malignant Neoplasms;Mediating;Metabolism;microorganism interaction;migration;Molecular;neutrophil;novel therapeutic intervention;Optics;Pathologic;Process;repaired;Research;Research Personnel;Resolution;response;Ribosomes;Role;Signal Transduction;tissue repair;Tissues;transcriptome sequencing;Translating;Work;wound healing;Wound models;Zebrafish

PROJECT_TITLE: Cell migration and wound repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Project Narrative: For reasons that are not fully understood, sensory hair cells in the inner ear die off with age likely contributing to loss of balance function which is one of the most pervasive and costly public health concerns for older adults. Preliminary evidence herein suggest that the pro- survival gene, Pou4f3, which is highly expressed in inner ear hair cells, is downregulated with age in a fashion that precedes hair cell death and dysfunction. We therefore propose experiments to better understand the regulation of Pou4f3 expression with age, to directly test whether targeted genetic disruption of Pou4f3 causes hair cell death and balance dysfunction, and to determine whether overexpression of Pou4f3 can prevent age-related declines in balance function.

PI_NAMEs: COX, BRANDON C.;WALTERS, BRADLEY J. (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: 129 Mouse;3xTg-AD mouse;Adult;Age;Age Months;age related;age related decline;Aging;aging process;Alleles;Alzheimer's disease model;Alzheimer's disease related dementia;Animals;ATAC-seq;Auditory;C57BL/6 Mouse;cell age;Cell Death;Cell Survival;Cells;Cessation of life;Classification;Cochlea;cognitive function;cognitive performance;cost;Data;Developmental Gene;DNA;Down-Regulation;Ear;Elderly;Embryonic Development;Equilibrium;Exhibits;experimental study;falls;FDA approved;Female;Financial cost;Foundations;Functional disorder;gene therapy;Genes;Genetic;genetic deafness;Genomics;Germ Lines;Hair Cells;Health;Healthcare;Hearing;Human;immunoreactivity;Impaired cognition;Injections;Inner Hair Cells;Investigation;Labyrinth;Link;Location;male;Modeling;morris water maze;Motor;mouse model;Mus;Mutation;Nervous System Physiology;noise exposure;novel;object recognition;old mice;older adult;Organ;overexpression;Pathology;Pattern;pharmacologic;Phenotype;Population;postnatal;Presbycusis;preservation;Prevalence;prevent;Prevention approach;progressive hearing loss;Public Health;Quality of life;Reflex action;Regulation;Regulatory Element;response;Role;Sensorimotor functions;Sensory;Sensory Hair;Sex Differences;Synapses;System;Tamoxifen;Task Performances;Temporal bone structure;Testing;therapeutic target;Time;Tissues;transcription factor;Vestibular dysfunction;Vestibular epithelia;Vestibular function;Vestibular Function Tests;Vestibular Hair Cells;vestibular system

PROJECT_TITLE: The role of Pou4f3 in age-related vestibular dysfunction


NIH_SPENDING_CATS: Genetics;Human Genome

PHR: Project Narrative  An outstanding question in genetics and cell biology is the implication of individual changes in chromosome number (aneuploidy). We will identify patterns of aneuploidy in healthy human cells and study its downstream effects using recently developed computational and genome engineering approaches. This research will advance our knowledge of the consequences of aneuploidy.

PI_NAMEs: TAYLOR, ALISON M. (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Aneuploid Cells;Aneuploidy;Atlases;cancer cell;Cell Cycle;Cell Cycle Arrest;Cell Line;Cells;Cellular biology;Chromosome Arm;Chromosome Deletion;Chromosomes;Computational algorithm;Data;Dedications;Dependence;Disease;DNA biosynthesis;Event;Genes;Genetic;Genome engineering;Genomics;Goals;Human;Human body;In Vitro;Individual;Knowledge;Libraries;Methods;next generation sequencing;Pattern;Phenotype;Population;programs;Research;Research Proposals;single cell sequencing;Testing;Tissues;transcriptomics;Work

PROJECT_TITLE: Functional Understanding of Chromosome Arm Aneuploidies

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Cancer;Colorectal Cancer;Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Microbiome;Nutrition;Prevention

PHR: PROJECT NARRATIVE Colorectal cancer is influenced by the immune system, which is itself regulated by intestinal microbial metabolites. These metabolic signaling pathways present an opportunity for therapeutic immune remodeling to improve CRC outcomes ranging from prevention to enhancing chemotherapy and immunotherapy. The objectives of this study are to delineate pathways by which microbial metabolites regulate immune cells, engineer a probiotic microbial strain to locally deliver therapeutic metabolites, and test the impact on CRC of using microbial metabolites for immunoregulation – united by a common focus on RORgt+ Tregs, a critical anti- inflammatory immune cell population in the intestine.

PI_NAMEs: ARPAIA, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: 16S ribosomal RNA sequencing;Affect;anti-cancer;Anti-Inflammatory Agents;Antibiotics;Aryl Hydrocarbon Receptor;Bile Acids;Butyrates;Cancer Model;Cell Count;Cell Proliferation;cell type;Cells;Chemoprotective Agent;chemotherapy;Colitis;Colitis associated colorectal cancer;Colon;Colon Carcinoma;Colorectal Cancer;colorectal cancer risk;colorectal cancer treatment;conditional knockout;cytokine;Data;Development;dextran sulfate sodium induced colitis;Diet;dietary;efficacy evaluation;Engineered Probiotics;Engineering;Enzymes;Epithelium;Escherichia coli;Essential Genes;Event;Gastrointestinal tract structure;Genetic Engineering;Germ Lines;Gnotobiotic;Goals;Growth;gut microbes;gut microbiome;gut microbiota;Immune;immune cell infiltrate;immune modulating agents;Immune signaling;Immune system;Immune Targeting;Immunity;immunological intervention;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Indole-3-Carbinol;Inflammatory Bowel Diseases;insight;Interleukin-10;Intervention;intestinal epithelium;Intestines;Knockout Mice;Knowledge;Link;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Microbe;microbial;microbiome;Modeling;Mucosal Immune Responses;Mus;Mutagenesis;Mutation;neoplasm immunotherapy;novel;Outcome;Oxygen;Pathway interactions;Plants;Population;Prevention;Probiotics;Production;Proliferating;promoter;protective effect;Receptor Signaling;reconstitution;Regulatory T-Lymphocyte;response;Role;sensor;Serum;Signal Pathway;Signal Transduction;Source;Supplementation;synthetic biology;T-Lymphocyte;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;Tissues;Tryptophan;tumor;Volatile Fatty Acids;Work

PROJECT_TITLE: Treating colon cancer by regulating intestinal immunity through microbial metabolism

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_CITY: Durham

ORG_NAME: RHO FEDERAL SYSTEMS DIVISION, INC.

PHR: PROJECT NARRATIVE The NIAID Clinical Data and Safety Management Center (CDSMC) is a consolidated clinical support service center conceived to manage NIAID’s portfolio of clinical research in allergic diseases, asthma, autoimmune disorders, and immune-mediated complications of transplant, continuing programs supported by Rho under prior awards. Our vision is to advance NIAID’s history of successful clinical research by continuing our successful collaboration in data management, safety, and specimen tracking with a focus on continuity while embracing innovation. Over the last two decades, innovation has dramatically changed clinical trial operations, with the technology revolution advancing trial data systems and advances in biology enabling research to halt disease processes, and the Rho team seeks to continue our support of NIAID’s work to deliver on this promise.

PI_NAMEs: SCHMIDT, PETER N. (contact);SNYDER, CATHIE

PROGRAM_OFFICER_NAME: THOMAS, LEIGHTON A

PROJECT_TERMS: Accountability;Achievement;Address;Adoption;Adverse event;Age;Allergic Disease;allotransplant;Area;Asthma;Autoimmune Diseases;Award;Biology;Budgets;Clinical;Clinical Data;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Communication;Computers;congenital immunodeficiency;Data;Data Collection;data management;data quality;Databases;Dedications;Development;Disease;electronic data;Electronics;Ensure;Environment;Event;Evolution;experience;Foundations;Funding;Generations;Goals;Hypersensitivity;Immune;immune function;Immune System Diseases;Immunologic Deficiency Syndromes;Immunology;improved;Individual;Industry;Information Systems;innovation;insight;International;Investments;Leadership;Life Cycle Stages;Mediating;Medidata;meetings;National Institute of Allergy and Infectious Disease;Nature;New York;Office of Administrative Management;operation;organizational structure;Paper;Performance;pharmacovigilance;prevent;Principal Investigator;Process;process improvement;programs;Recording of previous events;Reporting;Research;Research Design;Research Support;Resolution;rho;Risk;Safety;Safety Management;Sampling;Scientist;service organization;Services;software as a service;Specific qualifier value;Specimen;Specimen Handling;Structure;Summary Reports;System;systems research;Technology;Time;Transplantation;United States National Institutes of Health;Vision;Work;Xenograft procedure

PROJECT_TITLE: RhoFED CDSMC


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Adolescents’ involvement in medical decision making related to a chronic illness may lay the groundwork for effective and independent illness management as youth mature. The primary goal of this proposal is to develop a self-report questionnaire to assess youths’ involvement in decision making during outpatient visits for pediatric chronic illness (specifically, type 1 diabetes, sickle cell disease, juvenile idiopathic arthritis, and inflammatory bowel disease). Data from this project will lead to more nuanced clinical approaches to enhance youth participation in medical encounters, promote independent interactions with the health care system, and improve health behaviors and outcomes.

PI_NAMEs: MILLER, VICTORIA ALLISON (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;Age;Agreement;Behavior;Caring;Characteristics;Child;Child Rearing;Childhood;Chronic;Chronic Childhood Arthritis;Chronic Disease;Clinical;cognitive interview;Communication;Complex;Data;Decision Making;demographics;Development;Dimensions;Educational process of instructing;Empirical Research;Enrollment;Ensure;ethnic disparity;ethnic minority;Ethnic Origin;Evaluation;experience;Family;global health;Goals;Health;Health behavior;Health behavior and outcomes;health care disparity;health disparity;health management;Health Personnel;Healthcare;Healthcare Systems;Hispanic;improved;Inflammatory Bowel Diseases;Insulin-Dependent Diabetes Mellitus;Intervention;Interview;Legal;Measurement;Measures;Medical;medical specialties;minority children;Modeling;Modernization;Nature;NIH Program Announcements;Not Hispanic or Latino;Outcome;Outpatients;Parents;Participant;Patient Self-Report;Patients;Pattern;Phase;Play;Process;Professional Organizations;Property;Provider;provider behavior;Psychometrics;Quality of Care;Questionnaires;Race;racial disparity;racial minority;Research;response;Role;Self Efficacy;Self Management;shared decision making;Sickle Cell Anemia;skills;sociodemographics;sound;Structure;Testing;theories;Time;treatment adherence;Typology;Underrepresented Minority;Visit;Voice;Work;Youth

PROJECT_TITLE: Adolescents’ involvement in decision making during specialty care visits for pediatric chronic illness: Development and evaluation of a new measure and implications for self-management

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]