NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Hearing Loss;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative The goal of this research project is to test the hypothesis that that the experiences of listeners in their daily lives can be more strongly related to performance in a controlled test environment by using enhanced environments involving both virtual reality elements and game-based modifications to the testing procedures. A secondary, and potentially alternative, hypothesis is that the benefit of these enhancements will vary based on individual differences. Upon completion of this project there will exist, freely available, an extensive set of engaging, enhanced auditory assessments with established regions of normal performance as a function of age and hearing loss, and known relationships to various established tests of speech in noise that run on inexpensive consumer-grade equipment.

PI_NAMEs: GALLUN, FREDERICK J. (contact);SEITZ, AARON R;STECKER, GEORGE CHRISTOPHER

PROJECT_TERMS: Address;Age;age difference;Algorithms;Attention;Auditory;auditory processing;auditory stimulus;Brain Injuries;Clinic;Cognitive;cognitive ability;cognitive skill;Complex;cost;Data;data quality;Data Set;Dimensions;Effectiveness;Elements;Environment;Equipment;Etiology;Evaluation;experience;experimental study;Feedback;Goals;Healthcare;Hearing;Hearing Aids;hearing impairment;hearing range;Hearing Tests;Impairment;improved;Individual;Individual Differences;innovation;Laboratories;Literature;Location;Measures;Mediating;mild traumatic brain injury;Modeling;Modification;Motivation;new technology;Noise;normal hearing;Normal Range;Older Population;Participant;patient engagement;Patient Self-Report;Patient-Centered Care;Patients;Performance;performance tests;Persons;Phase;Predictive Factor;Procedures;Psychometrics;Psychophysics;Recording of previous events;Rehabilitation therapy;Reporting;Research;research clinical testing;Research Project Grants;Rewards;Running;Source;Speech;speech in noise;Statistical Models;Stimulus;Structure;Test Result;Testing;Time;Training;Validity and Reliability;Variant;virtual reality;virtual reality system;Visual;visual stimulus;Work

PROJECT_TITLE: Enhanced environments for psychophysical evaluation and training

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE During development, individual neurons extend highly branched neurites that innervate the surrounding territory with minimal overlap to form appropriate synaptic connections and failure to establish proper neural networks has been linked to neurodevelopmental and neuropsychiatric disorders, including Autism Spectrum Disorder, Schizophrenia and Major Depressive Disorder. Our proposal will investigate the molecular mechanisms by which de novo single nucleotide variants in the protocadherin gene cluster identified in ASD cases contribute to the etiology of ASD by altering neural circuit formation during development. This work aims to provide new insights into disease mechanisms, motivating the development of new therapeutic interventions.

PI_NAMEs: MANIATIS, THOMAS P (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Affect;Alleles;anxiety-related behavior;autism spectrum disorder;B-Lymphocytes;Bar Codes;Behavior;Binding;Binding Proteins;Biological;Biological Assay;Bipolar Disorder;Brain;causal variant;Cell Aggregation;Cell Communication;Cell Culture Techniques;Cell Line;Cell membrane;Cell surface;Cell Surface Proteins;cell transformation;Cells;Cellular Assay;Chromatin;cohort;Collaborations;Complex;CRISPR/Cas technology;Data;Defect;Development;Disease;DNA Sequence;DNA sequencing;Dominant-Negative Mutation;Dorsal;Epilepsy;Etiology;excitatory neuron;Failure;Family;functional restoration;Future;gain of function;Gene Cluster;Gene Expression;gene function;Genes;Genetic;genetic association;Genetic Risk;genome-wide;Goals;Guide RNA;Human;Human Genetics;human induced pluripotent stem cells;In Vitro;in vivo;Individual;Induced pluripotent stem cell derived human neuron;inhibitory neuron;insight;Intellectual functioning disability;Joints;K562 Cells;knock-down;Knockout Mice;Knowledge;Link;loss of function;lymphoblastoid cell line;Major Depressive Disorder;Mammals;Membrane;Methods;Microcephaly;Modeling;Molecular;Mus;mutant;Mutation;Nature;neural;neural circuit;neural network;Neurites;Neurodevelopmental Disorder;neuronal circuitry;Neurons;neuropsychiatric disorder;novel;novel therapeutic intervention;Pathogenesis;Pathway interactions;Pattern;Play;prevent;Privatization;proband;Protein Isoforms;protein structure;Proteins;rare variant;Regulation;Role;Schizophrenia;Single Nucleotide Polymorphism;Structure;Surface;Synapses;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;trafficking;Transfection;transforming virus;Variant;variant detection;Work

PROJECT_TITLE: The impact of loss of function DNA sequence variants in the human protocadherin gene cluster on neural circuit assembly.

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Hepatitis;Infectious Diseases;Liver Disease

ORG_CITY: WASHINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative Hepatitis delta virus causes serious acute and chronic liver disease but lacks effective treatment. To develop therapies and tackle the disease, it is necessary to better understand the virus’ unique replication strategy, which relies on the synthesis of three viral RNAs. This project will apply newly developed methods from my laboratory to advance our basic understanding of key processes in the synthesis of these viral RNAs.

PI_NAMEs: CASEY, JOHN L (contact)

PROGRAM_OFFICER_NAME: FLORES, AMANDA CHRISTINE

PROJECT_TERMS: acute liver disease;Affect;Catalytic RNA;cell type;Cells;chronic liver disease;circular RNA;design;Disease;DNA Polymerase II;DNA-Directed RNA Polymerase;effective therapy;Elements;experimental study;Genome;Genomics;Genotype;Hepatitis delta Antigens;Hepatitis Delta Virus;Human;human pathogen;Immune response;Infection;insight;Knowledge;Laboratories;Length;Licensing;Life Cycle Stages;Ligation;Liver diseases;Messenger RNA;Methods;Modeling;Modification;monomer;Mutation;novel strategies;Nucleocapsid;Pathogenesis;Polymerase;Positioning Attribute;Process;Proteins;Replication-Associated Process;Reporting;RNA;RNA chemical synthesis;RNA Ligase (ATP);RNA Polymerase II;RNA replication;RNA Sequences;RNA Viruses;RNA-Directed RNA Polymerase;Role;Series;Site;structural determinants;Structure;System;Testing;Therapeutic;therapy development;Time;tool;Transfection;Variant;Viral Genome;viral RNA;Virus;Virus Replication;Woodchuck;Work

PROJECT_TITLE: Dynamics of HDV RNA Synthesis

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Immunization;Immunotherapy;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: HOUSTON

ORG_NAME: 7 HILLS PHARMA, LLC

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chagas disease (CD) is a global health concern, with no existing therapies to prophylactically treat adults traveling to endemic countries or those who may already be infected with Trypanosoma cruzi (Tc). This proposal aims to develop a vaccine-adjuvant combination comprising a DNA vector-based bicistronic vaccine (BCV) and a systemic small-molecule integrin activator adjuvant for the control of Tc infection and CD, and demonstrate preclinical proof-of-concept, efficacy and safety of this vaccine-adjuvant combination in preparation for a Phase I/IIa clinical trial.

PI_NAMEs: DE, SIDDHARTHA ;GARG, NISHA JAIN;MARATHI, UPENDRA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;adaptive immunity;Adjuvant;Adult;Adverse reactions;Alleles;aluminum sulfate;Animal Model;Antibody Response;Antigen Presentation;Antigen-Presenting Cells;Antigens;Applications Grants;Biodistribution;Bioinformatics;Biological;Biological Assay;Biological Availability;Biological Markers;Biological Testing;Blood specimen;Canis familiaris;capsule;Cardiomyopathies;Cell Adhesion;Cell Adhesion Molecules;cell motility;Cessation of life;Chagas Disease;chagasic cardiomyopathy;Chronic;Clinical;Clinical Research;Clinical Trials;Codon Nucleotides;Collaborations;commercialization;Country;cytokine;Cytotoxic T-Lymphocytes;design;Development;DNA;DNA Vaccines;Dose;Drug Kinetics;Economic Burden;Effectiveness;efficacy evaluation;efficacy study;Epitopes;expression vector;Female;Formulation;Future;global health;Good Manufacturing Process;Health Care Costs;Heart failure;Human;Hypersensitivity;Immune;Immune response;Immunity;Immunization;immunogenicity;Immunoglobulin G;Immunotherapy;improved;In Vitro;Infection;Innate Immune Response;Integrins;Intercellular adhesion molecule 1;Interruption;Intramuscular Injections;Investigation;Investments;Latin America;Lead;Ligands;Lipids;male;manufacture;Mediating;Memory;migration;Modeling;Monitor;mouse model;Mus;Mycobacterium tuberculosis;novel;Oral;Parasites;pathogen;Pathogenesis;Pathogenicity;Phase;Phenotype;Plasma;Play;pre-clinical;preclinical efficacy;preclinical safety;preclinical study;premature;Preparation;product development;Production;Productivity;prophylactic;prototype;receptor;Regimen;Research;response;Risk;Role;Safety;safety assessment;Small Business Innovation Research Grant;small molecule;Study Subject;T cell differentiation;T cell response;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Tissues;transmission process;Travel;Treatment Efficacy;Trypanosoma cruzi;United States National Institutes of Health;Vaccination;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;Vaccine Production;vaccine safety;Vaccines;Vascular Cell Adhesion Molecule-1;vector;Work

PROJECT_TITLE: Integrin activator-adjuvanted DNA vaccine against Trypanosoma cruzi infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Genetics;Human Fetal Tissue;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative The T cell immune attack on pancreatic islet beta cells that causes Type I diabetes (T1D) might be due to abnormal development of T cells in the thymus, the organ that generates and educates T cells. We have used a unique human immune system mouse model in which human T cells develop in a human thymus to identify abnormalities in thymic T cell development and education when they are derived from T1D patient hematopoietic stem cells (HSCs). The goal of our proposed studies is to better understand the genetic and signaling abnormalities in T1D HSCs that result in the thymic selection and migration into the immune system of T cells with the capacity to destroy that patient’s own pancreatic beta cells.

PI_NAMEs: SYKES, MEGAN  (contact);WINCHESTER, ROBERT J

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Affinity;Amino Acids;Antigens;Apoptosis;Apoptotic;Autoantigens;Autoimmune;Autoimmune Diabetes;Autoimmune Diseases;Autoimmunity;Autologous;Automobile Driving;autoreactive T cell;autoreactivity;Beta Cell;Binding;Cells;central tolerance;Clonal Deletion;Clone Cells;complementarity-determining region 3;Data;Defect;Dependence;Development;diabetes risk;Disease;Distal;Education;Event;Gene Transfer Techniques;Genes;Genetic;Genetic Polymorphism;genetic risk factor;genetic variant;Goals;Hematopoietic stem cells;Human;Hydrophobicity;Immune;Immune system;Impairment;Inbred NOD Mice;induced pluripotent stem cell;insight;Insulin;Insulin deficiency;Insulin-Dependent Diabetes Mellitus;islet;islet autoimmunity;Islets of Langerhans;Knowledge;Mediating;MHC antigen;MHC Interaction;migration;Mitogen-Activated Protein Kinases;mouse model;Mus;Nature;novel;Organ;Pathogenicity;Pathway interactions;Patients;Peptides;Peripheral;Population;Predisposition;Process;Receptor Signaling;Regulatory T-Lymphocyte;Relative Risks;Replacement Therapy;risk variant;Role;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;single-cell RNA sequencing;Structure of beta Cell of islet;Structure of thymic cortex;T Cell Receptor Signaling Pathway;T-Cell Development;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;thymocyte;Thymocyte Selection;Thymus Gland;Tissues;Transgenes;Transgenic Organisms;Type I Insulin;virtual

PROJECT_TITLE: Thymic selection abnormalities in Type 1 Diabetes

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative When developing new cancer treatments, many scientists use animal models in which human tumors are implanted into research animals (i.e. patient-derived xenografts or PDXs). Despite the popularity of these models, we lack understanding of how we bias our results based on the methods we use to make new PDXs (e.g. implanting tumor pieces under the skin of immunocompromised mice as opposed to implanting into the site of origin). To improve the efficiency of pre-clinical research, this proposal will provide a clear answer to this question in head and neck cancer by methodically studying the site of implant, the age of the tumor, and the influence of an immune system on the tumor biology, evolution, and treatment response.

PI_NAMEs: KIMPLE, RANDALL J. (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Address;Affect;Age;Animal Experimentation;Animal Model;Animals;anti-cancer treatment;Biological;Biological Models;Biology;Cancer Model;cancer therapy;Caring;Cetuximab;Clinical;Clinical Trials;cost;Data;Decision Making;DNA sequencing;Evolution;expectation;experience;Funding;Generations;Genetic;Genetic Variation;Goals;Head and Neck Cancer;head and neck cancer patient;Histologic;HPV positive;HPV-negative head and neck cancer;Human;Human Biology;human disease;human model;humanized mouse;Immune;immune cell infiltrate;Immune system;Immunocompetent;Immunocompromised Host;Immunotherapy;Implant;implantation;improved;improved outcome;In Situ;In Vitro;innovation;Longevity;Malignant Neoplasms;Methodology;Methods;Modeling;Molecular;mouse model;Mus;Nose;novel;novel therapeutics;Operative Surgical Procedures;Oral;Organoids;Outcome;Pathway interactions;Patient Care;patient derived xenograft model;patient response;Patients;Pharyngeal structure;pre-clinical;pre-clinical research;prevent;Primary Neoplasm;Research;Resistance;response;Role;Sampling;Scientist;Serial Passage;Signal Pathway;single-cell RNA sequencing;Site;Skin;Source;Specimen;Squamous cell carcinoma;Squamous Epithelium;standard care;subcutaneous;Subcutaneous Tissue;targeted treatment;Testing;Therapeutic Studies;therapy resistant;Time;Translating;translational model;treatment response;tumor;Tumor Biology;tumor microenvironment;tumor-immune system interactions;Use Effectiveness;Wisconsin

PROJECT_TITLE: Improving the translational value of head and neck cancer patient-in-mouse models

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Narrative The long-term goal of this project is to develop, characterize and validate genetically modified marmosets that exhibit brain pathology and/or clinical/behavioral signs compatible with sporadic Alzheimer's Disease (AD). These marmoset models are aimed at informing human AD across the full life span or throughout the disease- relevant stages and serve as tools to interrogate molecular disease mechanisms and identify therapeutic targets. Specifically, as APOE4 allele is the most important risk factor for sporadic AD, marmosets carrying a complete loss of APOE or a point mutation mimicking APOE4 will be generated.

PI_NAMEs: LEE, KUO-FEN  (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Affect;age related;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amino Acids;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animals;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Apolipoproteins A;Arginine;Behavioral;Biochemical;Biological Models;Body Size;Brain;Brain Pathology;Callithrix;cerebrovascular;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;cognitive testing;Complex;Cysteine;Dementia;Dementia with Lewy Bodies;Disease;early onset;Environmental Risk Factor;Exhibits;familial Alzheimer disease;Fishes;fly;gain of function;gene editing technology;Gene Modified;Genes;genetic linkage analysis;Genetic Models;genetic variant;genome wide association study;Genomics;Genotype;glucose metabolism;Goals;Guide RNA;Homeostasis;Human;immune function;Incidence;Infection;Inflammation;Inflammatory Response;life span;Link;Lipid Binding;lipid transport;lipidomics;Lipopolysaccharides;Magnetic Resonance Imaging;Mediating;Meta-Analysis;Metabolism;Microglia;Modeling;Molecular;Molecular Disease;Mus;mutant;Mutation;Nerve Degeneration;neuroimaging;neuropathology;Neurosciences Research;nonhuman primate;null mutation;overexpression;Parkinson's Dementia;Pathology;Pathway interactions;Phenotype;Point Mutation;Positioning Attribute;Positron-Emission Tomography;Predictive Value;presenilin-1;presenilin-2;Primates;protective allele;Protein Isoforms;protein TDP-43;Proteins;rare variant;Relative Risks;Reproducibility;reproductive;Research;response;Risk;Risk Factors;risk variant;Role;sex;Signal Transduction;social;Structure;Synapses;tau Proteins;Tauopathies;Testing;therapeutic target;Threonine;tool;Transgenic Mice;transgenic model of alzheimer disease;Translating;translational neuroscience;Variant;Woman

PROJECT_TITLE: Genetic models of sporadic Alzheimers Disease in the marmoset


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Genetics;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: NARRATIVE Mutations in the lamin A/C gene cause a severe type of heart dysfunction called dilated cardiomyopathy. The goal of this project is to investigate a novel mechanism that may normally protect heart muscle cells from mechanical forces but lead to damage when persistently activated in patients with lamin A/C gene mutations. This fundamental research could uncover new ways to treat this life-threatening inherited heart disease.

PI_NAMEs: GUNDERSEN, GREGG G;WORMAN, HOWARD J (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: actin 2;Actins;Affect;Biological Assay;Biological Models;Biology;Bundling;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cell Nucleus;Cells;checkpoint inhibition;Complex;Contracts;Cytoskeleton;Data;Defect;design;Dilated Cardiomyopathy;Disease;DNA Damage;env Gene Products;familial dilated cardiomyopathy;Feedback;FHOD3 gene;Fibroblasts;Functional disorder;fundamental research;Gene Abnormality;Gene Expression;Gene Mutation;Genes;Goals;Heart;Heart Diseases;Human;in vivo;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;Lamin Type A;Lead;Life;live cell imaging;Maintenance;MAPK3 gene;Measures;mechanical force;Mechanical Stress;Mechanics;Mediating;Microfilaments;mimetics;mouse model;Movement;Mus;Mutation;Myocardial dysfunction;novel;Nuclear;Nuclear Envelope;Nuclear Lamina;Nuclear Outer Membrane;Nuclear Structure;Pathogenesis;Pathogenicity;Pathology;Patients;Phenotype;Phosphorylation;Physiological;Physiology;Positioning Attribute;prevent;Process;Proteins;Research;response;Role;Rupture;Sarcomeres;sensor;Signal Pathway;Signal Transduction;Stress;stress reduction;Structural Protein;Testing;Variant;Visualization;Wild Type Mouse

PROJECT_TITLE: Mechanistic Basis of Cardiac Laminopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health;Neurosciences

ORG_CITY: CHESTNUT HILL

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON COLLEGE

ORG_STATE: MA

PHR: PROJECT NARRATIVE Young, middle-aged and older adults work together, recreate together, and share many of life’s emotional highs and lows with one another. Yet sometimes, while the positive and negative experiences may be shared across the generations, the memory traces later accessed may differ. Here, we test the hypothesis that an individual’s age relates to the types of features of past emotional events that are brought to mind initially, and over successive retrievals, and we elucidate the characteristics of the memory representations that underlie these behavioral differences.

PI_NAMEs: KENSINGER, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: HOROWITZ, TODD S

PROJECT_TERMS: Address;Adult;Affect;Age;age difference;age effect;age related;Aging;Agreement;Behavior;Behavioral;Brain;career;Categories;Characteristics;Cognition;Cognitive aging;cognitive neuroscience;Collaborations;Complex;Data;Decision Making;Emotional;emotional experience;Emotions;Episodic memory;Event;experience;fascinate;Feeling;forgetting;Friends;Functional Magnetic Resonance Imaging;Generations;Human;human old age (65+);Impairment;Individual;Intervention;Knowledge;Life;life span;Link;Measurable;meetings;member;Memory;memory retrieval;middle age;Mind;neural;older adult;Pattern;Persons;phenomenological models;Process;Qualifying;Recording of previous events;Reporting;Research;Resolution;Retrieval;Sensory;Social Network;Stimulus;success;Testing;Thinking;Time;Well in self;Work;young adult

PROJECT_TITLE: Bringing positive and negative events to mind: Effects of age on emotional memory retrieval

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Sleep Research

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Narrative  This project aims to decipher potential role of a class of histone methyltransferases, COMPASS H3K4 methyltransferases, in environmental-circadian alignment. If successful, the results will unveil the molecular mechanism of a fundamental biological process, i.e. how organisms synchronize daily internal circadian rhythms with external environmental cycles. It will also lay the foundation for therapeutic avenues for conditions associated with shiftwork, a type of environmental circadian disruption, such as obesity and cancers.

PI_NAMEs: DUONG, HAO  (contact)

PROGRAM_OFFICER_NAME: SESMA, MICHAEL A

PROJECT_TERMS: Acceleration;Biological Process;Carcinogens;Cardiovascular Diseases;career;Cells;Chromatin;chromatin immunoprecipitation;Chromatin Remodeling Factor;circadian;circadian biology;Circadian Dysregulation;Circadian gene expression;circadian pacemaker;Circadian Rhythms;Classification;Clock protein;Co-Immunoprecipitations;Complex;Dependence;Developing Countries;Development;disadvantaged background;Disease;DNA Methylation;DNA Modification Methylases;Eating;Ensure;experimental study;Foundations;Funding;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Grant;Health;histone methyltransferase;Histones;Hospitals;Human;Industrialization;Industry;International Agency for Research on Cancer;Jet Lag Syndrome;Knockout Mice;Leisures;Light;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Metabolic Diseases;Methods;methyl group;Methylation;Methyltransferase;Modeling;Molecular;Molecular Genetics;mouse genetics;mouse model;Multienzyme Complexes;next generation;Nutrient;Obesity;Organism;Pathologic;Pathway interactions;Pattern;Periodicity;Physiological;Play;Positioning Attribute;prevent;Probability;Process;Protein Analysis;Proteome;Proteomics;Publications;recruit;Reporting;Risk;RNA Interference;Role;Schedule;shift work;Sleep;Solid;Specificity;statistics;Stimulus;System;Systems Integration;Temperature;Testing;Therapeutic;Time;training opportunity;transmission process;Urbanization;Work

PROJECT_TITLE: Potential Role of Compass H3K4 Methyltransferase Complexes in Environmental Circadian-Alignment


ORG_NAME: EMORY UNIVERSITY

PHR: PROJECT NARRATIVE In this project, multifunctional biodegradable nanowires are being designed, manufactured and tested for their ability to interact with lung and nasal epithelial cells. Complexes that target an apically expressed cell adhesion molecule, β1 integrin, are being screened to identify nanowires that physiologically regulate airway epithelial function. One goal of this study is to evaluate β1 integrin as a target for the ability to improve the barrier function of the lung epithelium and as a novel therapeutic for chronic rhinosinusitis with nasal polyposis, a chronic disease with critically few treatment options.

PI_NAMEs: DESAI, TEJAL A.;KOVAL, MICHAEL H. (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Actins;Adopted;Affect;Air;airway epithelium;Antibodies;Apical;Architecture;Biological Assay;CD47 gene;Cell Adhesion Molecules;Cell Differentiation process;cell growth;Cell model;Cell Physiology;Cells;Characteristics;Chronic;Chronic Disease;chronic rhinosinusitis;Clinical;cohort;Collaborations;Complex;Crosslinker;Cultured Cells;cytokine;Cytoplasm;Cytoskeleton;Data;density;design;design and construction;Drug Controls;Drug Delivery Systems;electric impedance;Engineering;Epithelial Cells;Epithelium;F-Actin;flexibility;fluorescence lifetime imaging;Goals;Growth;Human;Impairment;improved;In Vitro;Inflammation;Inflammatory;Integrins;Knowledge;Label;Laboratories;Ligand Binding;Liquid substance;live cell microscopy;Lung;Lung Diseases;macromolecule;manufacture;Measurement;Measures;Mechanics;Membrane;Methods;Molecular;Molecular Conformation;Morphology;nanoscale;Nanostructures;Nanotopography;nanowire;Nasal cavity;Nasal Epithelium;Nasal Polyps;Nose;novel;novel therapeutics;Organoids;Otolaryngology;particle;Patients;Permeability;pharmacologic;Phenotype;Physiological;polycaprolactone;polyposis;Polyps;Proteins;Proteome;pulmonary function;Quality of life;Regulation;Resistance;Role;scaffold;Scaffolding Protein;sensor;Series;Specificity;Structure;Structure of mucous membrane of nose;subcutaneous;success;superresolution microscopy;Surface;Talin;Testing;Tight Junctions;Tissue Banks;Topical application;transcytosis;Work

PROJECT_TITLE: Regulation of epithelial function using targeted nanowires

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Messenger RNAs (mRNAs) encode specific regulatory instructions in their untranslated regions (UTRs) that govern when, where, and how much protein should be made from each mRNA. Our studies will investigate how mRNA UTR sequences fold into specific structures, and how these structures impact mRNA regulation. Our results will provide insights into how mutations in UTRs contribute to disease, help improve our ability to design molecular therapies that target UTRs to control gene expression, and facilitate efforts to design synthetic mRNAs as medicines.

PI_NAMEs: MUSTOE, ANTHONY MCDOWELL (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 3' Untranslated Regions;Area;Back;Base Pairing;Binding;Binding Sites;Biology;biophysical techniques;Cells;Chemicals;combinatorial;Complex;Data;design;Disease;Distal;Gene Expression;human disease;improved;insight;Instruction;Lesion;Link;Maps;Medicine;Messenger RNA;MicroRNAs;Modeling;Molecular;molecular targeted therapies;Mutation;next generation;Play;Post-Transcriptional Regulation;Proteins;Regulation;Research;Resolution;RNA;RNA-Binding Proteins;Role;single molecule;Site;Structure;Technology;therapeutic target;Translations;Untranslated Regions;Work

PROJECT_TITLE: Role of structural dynamics in RNA regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BCMB-B(55)]


ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE We seek to design a potent dual action immunostimulatory nanoparticle that reprograms and activates the innate immune cells because these cells recruit systemic immunity. Such approach can facilitate an antitumor immune response leading to tumor rejection and prevention of disease relapse.

PI_NAMEs: KARATHANASIS, EFSTATHIOS  (contact);WANG, LI LILY

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Adverse event;Agonist;anti-tumor immune response;cancer immunotherapy;Cells;cytotoxic CD8 T cells;design;Disease;disorder prevention;Disseminated Malignant Neoplasm;dosage;Ensure;environmental enrichment for laboratory animals;Frequencies;Gene Activation;Genes;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immunity;Immunoglobulin Domain;Immunologic Memory;Immunotherapy;in vivo;innovation;Lipids;lymphocyte trafficking;Malignant Neoplasms;Mediating;Melanoma;Metastatic breast cancer;Metastatic/Recurrent;Methods;mouse model;Myeloid Cells;Myeloid-derived suppressor cells;nanoparticle;Natural Immunity;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;Operative Surgical Procedures;Patients;programmed cell death protein 1;programs;Proteins;recruit;recurrence prevention;Recurrent disease;Recurrent tumor;Resistance;response;Safety;side effect;siRNA delivery;Small Interfering RNA;Solid Neoplasm;stem;Suppressor-Effector T-Lymphocytes;synergism;T-Cell Activation;T-Lymphocyte;targeted treatment;Testing;Therapeutic;therapy resistant;Toxic effect;Treatment Efficacy;tumor;tumor eradication;Tumor Immunity;tumor microenvironment;Tumor Volume;tumor-immune system interactions;uptake

PROJECT_TITLE: Dual action immunostimulatory nanoparticles for treatment of aggressive cancers


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Ribosome RNA (rRNA) modifying enzymes are important factors in the assembly and function of ribosomes, dysregulation of which is frequently seen in human hematopoietic disorders. However, whether and how the catalytic roles of rRNA modifying enzymes contribute to the physiology and pathology of human hematopoiesis remain elusive. Our research goal is to understand the catalytic roles of rRNA modifying enzymes in the regulation of cell viability and gene expression in hematopoietic stem progenitor cells.

PI_NAMEs: COOPERMAN, BARRY S.;LIU, FANGE  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Ablation;Affect;Basic Science;Biogenesis;Biological;Biological Assay;Cell Line;Cell Survival;cell type;Cells;Complex;cricket paralysis virus;CRISPR screen;Cytoplasm;Data;Development;Discipline;Disease;DNA Damage;DNA Repair;DNA Repair Pathway;Enzymes;Event;Fanconi's Anemia;Gene Expression;Goals;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Human;Human Pathology;Impairment;In Vitro;insight;Internal Ribosome Entry Site;Kinetics;Knowledge;Laboratories;Mediating;Messenger RNA;Methylation;Methyltransferase;Modification;Molecular;mRNA Decay;mRNA Translation;novel;novel therapeutics;Pathologic Processes;Pathway interactions;Peptide Initiation Factors;Peptides;Physiological Processes;Physiology;polypeptide;Process;Protein Biosynthesis;Reaction;Regulation;Reproducibility;Research;response;Ribosomal Frameshifting;Ribosomal RNA;Ribosomes;RNA;RNA Processing;RNA, Ribosomal, 18S;Role;scaffold;Site;Specificity;Structure;Structure-Activity Relationship;success;System;Transfer RNA;Translations;Variant

PROJECT_TITLE: Catalytic roles of RNA methyltransferase DIMT1

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Bioengineering;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Sepsis

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Critically ill patients admitted to the Intensive Care Unit (ICU) are at the risk of developing sepsis leading to death, each hour of delayed recognition or treatment can contribute to significantly increasing the likelihood of death. If this application is funded, we will explore sensor-generated continuous physiological data streams to extract ‘physiomarkers’ that predict the onset of sepsis, aid in informing intervention futility (volume responsiveness) and support the discovery of novel sepsis sub-types. By discovering and modeling the mechanisms by which such physiomarkers predict sepsis, we can proactively recognize specific high-risk patients, appropriate resources at the right time to avoid significant morbidity and mortality, and begin treatments that improve outcomes in this critically ill and vulnerable population.

PI_NAMEs: KAMALESWARAN, RISHIKESAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Admission activity;Adult;Algorithms;Blood Pressure;Bolus Infusion;Cessation of life;Characteristics;Clinical;Clinical Data;clinical decision-making;clinical phenotype;clinical practice;Complex;computer science;Computerized Medical Record;Critical Illness;Data;Data Sources;data streams;day length;Death Rate;Deterioration;Development;differential expression;Effectiveness of Interventions;Electrocardiogram;Electrophysiology (science);Encapsulated;Face;Fluid Balance;Fluid Therapy;Functional disorder;Funding;Futility;General Ward;Goals;Health;hemodynamics;Heterogeneity;high risk;Hospital Mortality;Hospitalization;Hospitals;Hour;Human;improved;improved outcome;insight;Institution;Intensive Care Units;Intervention;Knowledge;knowledge integration;learning algorithm;Length of Stay;Literature;Machine Learning;machine learning algorithm;machine learning method;machine learning prediction;machine learning prediction algorithm;Manuals;Mathematics;Measures;Medicare;Medicine;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;Multiple Organ Failure;novel;novel marker;Organ;Outcome;Patient Admission;Patient Monitoring;Patients;pediatric sepsis;Phenotype;Physiological;Physiology;point of care;Population;predictive modeling;programs;Recovery;Reporting;Reproducibility;Resources;Risk;Role;secondary infection;sensor;Sepsis;septic patients;Severities;Shock;signal processing;Signal Transduction;Stream;Structure;structured data;targeted treatment;Testing;Time;tool;Training;Translations;Treatment Efficacy;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Sepsis Physiomarkers for Appropriate Risk Knowledge of monitored patients in the ICU (SPARK-ICU)

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mucin proteins comprise mucus, which coats the surface of all epithelial cells for hydration and pathogen defense. Diverse viruses have evolved to attach directly to mucins, but due to varied mucin forms, molecular details of binding preferences and their outcomes on viral evolution, diffusion, tissue specificity, and replication are lacking. We will develop synthetic mucins of precisely defined structure to unravel how viruses interact with host cell surfaces, which will improve our understanding of viral diseases and open doors to new therapeutics.

PI_NAMEs: KRAMER, JESSICA  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Adhesions;Amino Acids;Anti-viral Agents;Binding;Biology;biophysical properties;Cell surface;Cells;chemical property;citizen science;Complex;Development;Diet;Diffusion;Disease;disease transmission;Drug Delivery Systems;Engineering;Epithelial Cells;Epithelium;equity, diversity, and inclusion;Evolution;Future;Glycocalyx;Glycoproteins;glycosylation;Health;Heterogeneity;Host Defense;Human;Hydration status;Immunity;improved;Infection;Jellyfish;Knowledge;Life;Life Cycle Stages;Lubrication;Malignant Neoplasms;Mentors;Modeling;Molecular;Molecular Weight;Mucins;Mucous body substance;novel therapeutics;nutrient absorption;Outcome;pathogen;Pathway interactions;Pattern;Peptides;Play;polymerization;Polymers;polypeptide;Polysaccharides;preference;Prevention strategy;Proteins;response;Role;Sialic Acids;Specificity;Structure;sugar;surface coating;tissue tropism;Tissues;Underrepresented Populations;Vertebral column;Viral;Viral Genes;Virus;Virus Diseases

PROJECT_TITLE: Synthetic mucins in epithelial models to probe virus-mucin interactions


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: LEXINGTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative The proposed study will test the effectiveness, implementation outcomes, and cost effectiveness of a community-tailored, harm reduction kiosk in reducing HIV, hepatitis C, and overdose risk behavior in rural Appalachia. The proposed project will take place in two counties in Appalachian Kentucky, an epicenter for the intertwined national crises of injection drug use, overdoses, and hepatitis C.

PI_NAMEs: YOUNG, APRIL MARIE (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Appalachian Region;Callback;cohort;Communities;community academic partnership;community engagement process;condoms;cost effective;cost effectiveness;Country;County;Coupled;COVID-19;Data;design;Disease Outbreaks;Dropout;Drug user;Effectiveness;effectiveness study;effectiveness testing;effectiveness trial;Epidemic;Epidemiology;Equipment;experience;fentanyl test;flexibility;follow-up;Fright;Funding;Harm Reduction;Health;Hepatitis C;Hepatitis C Therapy;Hepatitis C Transmission;HIV;HIV/HCV;Home;Hour;Huntington Disease;Hybrids;Hygiene;implementation evaluation;implementation outcomes;improved;Indiana;Infrastructure;Injecting drug user;injection drug use;Injections;innovation;interest;Judgment;Kentucky;Laws;lectures;Letters;Medicaid;Methods;Modeling;Naloxone;Names;National Institute of Drug Abuse;Needle-Exchange Programs;Nevada;Newly Diagnosed;Opioid;outreach services;Overdose;overdose death;overdose risk;overdose risk behaviors;Persons;Pharmaceutical Preparations;Process;programs;Puerto Rico;Qualitative Research;Quasi-experiment;Recording of previous events;Recovery;Reporting;Research;Research Infrastructure;Resources;response;Risk;Risk Reduction;Rural;Rural Appalachia;rural area;rural setting;scale up;Science;Service delivery model;Services;social stigma;Sorbus;Statutes and Laws;substance use;Surveys;Syringes;test strip;Testing;Time;Training;Transportation;Unsafe Sex;uptake;West Virginia

PROJECT_TITLE: Kentucky Outreach Service Kiosk (KyOSK): Reducing HIV, HCV, and Overdose Risk in Rural Appalachia through Harm Reduction Kiosks

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes

PHR: Project Narrative  Obesity and diabetes mellitus have reached epidemic proportions worldwide. The goal of this grant is to train the next generation of scientists at the medical student, pre-doctoral, and post-doctoral level to conduct research that will impact the prevention and treatment of diabetes and other endocrine disorders.

PI_NAMEs: SEALE, PATRICK ;STOFFERS, DORIS A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Diabetes Mellitus;Endocrine;Metabolism

PROJECT_TITLE: Diabetes, Endocrine, and Metabolism

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: ALZHEIMER'S ASSOCIATION

ORG_STATE: IL

PHR: To encourage early stage investigators from a broad range of backgrounds to join the dementia research workforce, the Alzheimer's Association proposes to employ its substantial organizational and research resources to develop and implement an annual, week-long, dual track (psychosocial and public health) Alzheimer's Association Interdisciplinary Summer Research Institute (AA-ISRI) on Alzheimer's Disease and Related Dementias. At the end of each annual institute, attendees will be able to apply psychosocial and/or community-level, public health theory and measurement of systems to research design questions, resulting in an increase in new interventions focused on improving quality of life and system-level research in communities nationwide. Outcomes for the institute will include improved quality of life and ability to handle stress for individuals living with dementia and their care partners and increasing system-level change in community level organizations, such as health systems, employers, and financial institutions.

PI_NAMEs: FAZIO, SAM  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Acceleration;Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Awareness;Biological;Cancer Education Grant Program;career;Caring;Chicago;Clinical;Collaborations;Communication;Communities;Consultations;Course Content;Dementia;design;Development;Doctor of Philosophy;Educational Curriculum;Electronic Mail;Eligibility Determination;Evaluation;experience;Faculty;Familiarity;Feedback;Funding;Genetic;Goals;Grant;Health Policy;Health Services Research;Health system;Home;improved;Individual;Institution;Interdisciplinary Study;interest;Intervention;Journals;Knowledge;Lead;Learning;learning materials;lectures;Measurement;Measures;meetings;Mentors;Methods;Modification;Monitor;Nerve Degeneration;Outcome;outreach;Participant;Peer Review;Persons;Phase;Policies;prevent;Prevention;Primary Prevention;Program Sustainability;programs;psychologic;Psychology;psychosocial;Public Health;Publications;Quality of life;Questionnaires;Recording of previous events;recruit;Research;Research Design;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;response;Running;Schedule;Science;Scientist;Secondary Prevention;Services;skill acquisition;social stigma;Sociology;Speed;Stress;success;summer institute;summer research;Surveys;symposium;System;Technology;theories;therapy design;Time;timeline;tool;Training;Training and Education;Vision


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

ORG_CITY: Columbus

ORG_DEPT: PHYSICS

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE We propose a Molecular Biophysics Training Program (MBTP) that leverages the research and training experience of 27 faculty Trainers in three colleges and eight departments to create a unique training experience at the crossroads of the quantitative, molecular, and biomedical sciences. Students from three different graduate programs and many different backgrounds will have the opportunity to interact with and learn from each other and from the many experienced Trainers. This training will prepare graduates to address the biomedical challenges of the twenty--first century with truly collaborative and comprehensive approaches that address pressing needs in career development and inclusion of diverse groups.

PI_NAMEs: BUNDSCHUH, RALF A (contact);KURET, JEFF ;MAGLIERY, THOMAS J

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TITLE: Molecular biophysics predoctoral training at the Ohio State University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This project aims to gain a better understanding of and improve a new sub-class of wound healing biomaterial that has shown great promise in the treating of non-diabetic wounds. The goal of this project is to ensure that the material is optimized for improved healing by improving qualities associated with its wound interactions: minimizing inflammation, resisting premature scaffold degradation, and promoting new tissue formation.

PI_NAMEs: GRIFFIN, DONALD RICHIERI (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Acceleration;Address;Affinity;Amino Acid Substitution;angiogenesis;Animal Model;articular cartilage;Behavior;Biocompatible Materials;bioscaffold;Blood Vessels;Brain;cell behavior;Cell Line;cell motility;Cells;Chemicals;chemokine;Clinical;Complication;Crosslinker;Defect;Dermal;design;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic ulcer;diabetic wound healing;Diameter;Engineering;Environment;Enzymes;Exhibits;Family suidae;Foreign-Body Reaction;Formulation;Gel;Generations;Geometry;Goals;Hair follicle structure;healing;Heparin;Heterogeneity;Histology;Hydrogels;immune activation;Immune response;Immunofluorescence Immunologic;immunogenicity;immunoregulation;implantation;improved;In Situ;In Vitro;in vivo;Individual;Inflammation;Inflammatory;Injectable;Instruction;Intestines;Intramuscular;invention;Investigation;Island;limb amputation;Lower Extremity;Macrophage;Mechanics;Mediating;Microfluidics;Microscopic;Microspheres;migration;Natural regeneration;non-diabetic;novel;Outcome;particle;Pathologic;Patients;Peptides;Perfusion;Pilot Projects;Porosity;porous hydrogel;post stroke;Predisposition;premature;Proliferating;Property;Proteolysis;ratiometric;regenerative;Resistance;response;revascularization;scaffold;secondary outcome;Skin;Skin wound healing;Splint Device;standard of care;Structure;Testing;Thick;tissue regeneration;Tissues;Ulcer;wound;wound closure;wound environment;wound healing;Wound models;wound treatment

PROJECT_TITLE: Engineering Injectable Microporous Hydrogels for Diabetic Wound Repair


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Direct electrical stimulation of the brain holds promise for patients with refractory neuropsychiatric conditions and in particular treatment-resistant depression but has been limited to delivering a fixed stimulation pattern and shown variable efficacy in clinical trials. We propose that one way to improve efficacy is to build a novel model- based system that adjusts the stimulation based on recording brain signals that are related to mood symptoms and modeling how ongoing stimulation changes these signals. We will develop this novel model-based system to enable personalized real-time stimulation and test it for acute control of neural biomarkers of mood states related to depression symptoms in human epilepsy patients.

PI_NAMEs: SHANECHI, MARYAM  (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Alternative Therapies;Biological Markers;Brain;brain control;Brain region;Clinical Trials;comorbid depression;Controlled Clinical Trials;Data;Depressive disorder;depressive symptoms;disability;Disabling;Dissociation;Electric Stimulation;Electric Stimulation Therapy;Electrical Stimulation of the Brain;Electrodes;Electroencephalography;Elements;Epilepsy;Exhibits;experimental study;Feedback;Frequencies;Future;Human;Implant;Implanted Electrodes;improved;Individual;Knowledge;Learning;Machine Learning;Measures;Mental Depression;Modeling;Monitor;mood symptom;Moods;neural;neuropsychiatric disorder;neuropsychiatric symptom;neuropsychiatry;neuroregulation;novel;open label;Output;Patient Self-Report;Patients;Pattern;Pharmaceutical Preparations;predictive modeling;programs;Psychotherapy;Public Health;real time model;reduce symptoms;Refractory;Resistance;response;Rest;Running;Signal Transduction;Site;success;Symptoms;System;Technology;Testing;therapeutic target;Time;Training;treatment-resistant depression;Variant

PROJECT_TITLE: Model-based neural control of brain stimulation for neuropsychiatric disorders

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Cancer;Genetics

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Loss of heterozygosity contributes to cancer initiation and progression through the loss of the functional copy of a tumor suppressor gene in heterozygous individuals, leaving only the mutant copy. We have established and validated a system to study this phenomenon in stable diploid cells using a flow cytometry. Defining the factors that prevent or contribute to long-range loss of heterozygosity after double strand break formation will contribute to understanding of how these initiating events in cancer occur.

PI_NAMEs: REGAN, SAMANTHA BROOKE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Affect;Aneuploidy;anti-cancer research;Biological Assay;Breast;cancer initiation;Cell Line;Cells;Chromatids;Chromosomal Breaks;Chromosomal Instability;Chromosome Arm;Chromosomes;Colon Carcinoma;Complex;CRISPR/Cas technology;Cruciform DNA;Dangerousness;Data;daughter cell;Diploid Cells;DNA Damage;DNA Double Strand Break;DNA Repair Gene;Double Effect;Double Strand Break Repair;early screening;endonuclease;Event;Flow Cytometry;Fluorescent in Situ Hybridization;Frequencies;functional loss;Gene Conversion;Genes;Genetic Crossing Over;Genetic Nondisjunction;Genetic Recombination;Genome;Genome Stability;helicase;Heterozygote;high risk;Homologous Gene;homologous recombination;Individual;knock-down;Location;Loss of Heterozygosity;Malignant Neoplasms;Mammalian Cell;Modeling;mutant;Mutation;Nonhomologous DNA End Joining;Normal Cell;nuclease;Outcome;Ovarian;overexpression;Pathway interactions;Patients;Pattern;Premalignant Cell;prevent;Proteins;Research;Retinoblastoma;Role;segregation;Sister Chromatid Exchange;Site;Structure;Syndrome;System;Topoisomerase III;tumor;tumor progression;Tumor Suppressor Genes;Work;Yeasts

PROJECT_TITLE: Elucidating Mechanisms of Loss of Heterozygosity in Diploid Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Every time a cell divides, it must duplicate the DNA that contains the blueprint of the cell. If the DNA replication process stalls at sites of damaged DNA, the cell must engage the protein coded by the BRCA1 breast and ovarian cancer gene, and its associated proteins, to prevent DNA damage, mutation and cancer. In work described here, we will use powerful new tools, developed by the Scully lab, to study how BRCA1 performs this work and to use these insights in an effort to discover new targets for cancer therapy.

PI_NAMEs: SCULLY, RALPH  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Ablation;ATP phosphohydrolase;autosome;BRCA1 gene;BRCA2 gene;Breast Cancer therapy;cancer genome;cancer predisposition;Cell Cycle;Cells;Chromatin;Clinical;Code;Defect;Disease;DNA;DNA analysis;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;druggable target;Fanconi's Anemia;Funding;Genes;Genetic;Genomic Instability;Goals;Hereditary Breast and Ovarian Cancer Syndrome;homologous recombination;Human;human disease;innovation;insight;Light;Link;loss of function mutation;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;molecular targeted therapies;Motor;mutant;Mutation;novel therapeutics;Oncogenes;Outcome;prevent;Prevention;Proteins;Regulation;repaired;Replication-Associated Process;Reporter;response;Rest;Role;Site;success;synthetic lethal interaction;targeted cancer therapy;targeted treatment;Techniques;Therapeutic;Time;tool;Variant;Work;Yeasts

PROJECT_TITLE: Stalled replication fork repair in cancer predisposition and cancertherapy


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention;Rare Diseases;Telehealth

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Physical activity can reduce risk for a variety of chronic diseases including several types of cancer but, unfortunately, many individuals try but fail to be active (e.g., think New Year’s Resolutions). The purpose of this project is to evaluate if an intervention that uses methods from control systems engineering to adjust support to each person’s changing needs will promote increased physical activity compared to another intervention that does not use these methods.

PI_NAMEs: HEKLER, ERIC  (contact);RIVERA, DANIEL E

PROGRAM_OFFICER_NAME: VANDERPOOL, ROBIN CLINE

PROJECT_TERMS: actigraphy;adaptive intervention;Adherence;Adult;aged;Behavior;behavior change;Body Composition;Body Weight decreased;cancer prevention;Cancer Prevention Intervention;cancer risk;cancer type;Chronic Disease;Colon Carcinoma;Complex;cost effectiveness;Data;digital health;digital platform;Ecological momentary assessment;Education;Endometrial Carcinoma;Engineering;Event;exercise intervention;Fatty acid glycerol esters;Feedback;fitbit;global health;Glycosylated hemoglobin A;Goals;Guidelines;Health;high risk;high risk population;Hip region structure;Human;improved;Individual;innovation;Intervention;Literature;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mathematics;Measurement;Measures;Mental Health;Methods;mhealth interventions;Modeling;Monitor;multiphase optimization strategy;Nature;Obesity;Outcome;Overweight;Pain;Participant;Patient Outcomes Assessments;Persons;Physical activity;pilot test;Positive Reinforcements;prevent;Public Health;randomized trial;Randomized, Controlled Trials;Recommendation;Renal Carcinoma;Research;Resolution;response;Risk;Risk Reduction;Sequential Multiple Assignment Randomized Trial;simulation;Smoking;social cognitive theory;Stress;Substance abuse problem;System;Techniques;Testing;Time;tool;treatment arm;vigorous intensity;Walking;wearable device;Weight maintenance regimen;Work

PROJECT_TITLE: Optimizing Individualized and Adaptive mHealth Interventions via Control Systems Engineering Methods

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MIAMI

ORG_DEPT: MISCELLANEOUS

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Narrative  The U.S. is home to the largest population of Haitian immigrants in the world, yet little is known about Haitian immigrants living with HIV (HILWH) and their recent experiences throughout the HIV cascade of care. The purpose of this study is to develop, using mixed methods, multi-level formative data on perceived barriers and facilitators to engagement, retention, and viral suppression among HILWH. We will also adapt, pilot-test, and evaluate a multi-component intervention that addresses specific unmet needs leading to persistent HIV outcome disparities, including viral suppression, in Miami, Florida an epicenter of the epidemic.

PI_NAMEs: DEVIEUX, JESSY G. (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adult;Affect;African American;AIDS prevention;Award;Behavior Therapy;Behavioral;brief intervention;Caring;Client;clinical research site;Communities;comorbidity;connected care;contextual factors;Continuity of Patient Care;Country;Data;Dedications;design;Diagnosis;Effectiveness;Epidemic;Evaluation;evidence base;Evidence based intervention;experience;Face;Federally Qualified Health Center;Florida;follow-up;Foundations;Funding;Generations;Gravitation;Haiti;Haitian;Health Personnel;Hispanic Populations;HIV;Home;Immigrant;implementation determinants;implementation intervention;Improve Access;improved;improved outcome;internalized stigma;Intervention;Intervention Trial;Joints;Latinx population;Legal;Literature;Measures;Mental Health;Methods;Minority;Modeling;Motivation;motivational enhancement therapy;multi-component intervention;National Institute of Allergy and Infectious Disease;neglect;Outcome;outcome disparities;pandemic disease;Persons;pilot test;Population;Positioning Attribute;preventive intervention;Problem Solving;Production;Provider;Publications;Publishing;Quasi-experiment;Randomized;Reduce health disparities;Research;Research Personnel;Research Priority;Resources;response;Screening for cancer;service providers;social;social culture;social determinants;social stigma;socioeconomics;Standardization;stem;Stigmatization;Stroke;surveillance study;Techniques;Testing;therapy development;transmission process;United States;United States National Institutes of Health;Viral;Virus;Work

PROJECT_TITLE: Intervening with Haitian Immigrants in the U.S. to Improve HIV Outcomes

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention;Telehealth

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Mobile obesity interventions have the potential to reach a diverse population in need; however, while effective, have not resulted in weight losses obtained in in-person interventions. Newer digital approaches called Just-in- Time Adaptive Interventions (JITAI) that offer adaptive, personalized feedback `when needed' and in `real time' offer an opportunity to use digital health tools “just in time”. This study seeks to identify the optimal components of a comprehensive weight loss JITAI that results in weight losses that meet or exceed those in existing remotely delivered interventions.

PI_NAMEs: TATE, DEBORAH F. (contact)

PROGRAM_OFFICER_NAME: HALES, CRAIG MAURICE

PROJECT_TERMS: adaptive intervention;Address;Adult;Age;alternative treatment;Behavior;Behavior Therapy;Behavioral;Body mass index;Body Weight Changes;Body Weight decreased;Characteristics;Clinical;clinically significant;Collection;Competence;cost;Coupled;Decision Making;design;Development;Diet Monitoring;Dietary intake;digital;digital health;digital intervention;Distal;Electronic Mail;Engineering;Epidemic;Ethnic Origin;evidence base;Experimental Designs;experimental study;Feedback;follow up assessment;follow-up;Frequencies;Gender;Goals;health data;high risk;improved;Individual;individual variation;Informal Social Control;Internet;Intervention;Life Style;Mediation;Mediator;mHealth;middle age;Modeling;Monitor;Morbidity - disease rate;mortality;multiphase optimization strategy;Obesity;obesity treatment;Outcome;Overweight;Participant;Persons;Physical activity;Population;Population Heterogeneity;Public Health;public health intervention;Race;Randomized;randomized trial;remote delivery;Schedule;Science;skills training;Specific qualifier value;Structure;Testing;Text Messaging;therapy development;Time;tool;Treatment Protocols;United States;Update;web-based intervention;Weight;Weight Gain;weight loss intervention;Work;young adult

PROJECT_TITLE: Optimization of a mHealth Behavioral Weight Loss Intervention for Young Adults


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Functional status—a summary of a patient’s physical, emotional, and social wellbeing—is a key index that guides the treatment of older patients with chronic pain conditions. Clinical integration of smartphones promises to bridge the “digital divide” by offering new ways to measure functional status and expand access to real-time care in vulnerable populations who lack access to in-person clinical evaluations. Because 80% of Americans in their fifties and sixties own and use smartphones, we will define and implement a smartphone-based profile of functional status and pilot how such a digital biomarker profile might offer real-time clinical decision support in real-world patients.

PI_NAMEs: BARRON, DANIEL S. (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: Accelerometer;age related;American;Barbering;biomarker development;Caring;Cellular Phone;chronic pain patient;chronic painful condition;Client satisfaction;Clinic;Clinical;clinical care;clinical decision support;clinical practice;Clinical Services;Clinical Treatment;clinically relevant;Control Groups;Data;Decision Support Model;design;Development;Devices;digital;Digital biomarker;digital divide;digital health;digital measure;digital phenotyping;disability;disorder risk;Documentation;Economic Models;Ecosystem;Emotional;Emotions;Engineering;Entrepreneurship;Evaluation;experience;externship;Fostering;Foundations;Frequencies;functional decline;functional status;Future;Goals;Grant;Health;health economics;health equity;Health Policy;Healthcare;Impaired cognition;improved;indexing;Industry;Intervention;Measures;Mentors;Modeling;Monitor;Movement;Observational Study;older patient;overtreatment;Pain;Pain management;patient biomarkers;Patient Care;patient engagement;patient population;Patients;Pattern;Persons;Phenotype;programs;provider behavior;Quality of life;real time model;Research;research clinical testing;Research Personnel;Resolution;Services;Small Business Innovation Research Grant;social;Social Well-Being;Surveys;Symptoms;Teleconferences;Testing;Text;Time;tool;Training;Treatment outcome;treatment response;Treatment Side Effects;Visit;Vulnerable Populations;Work;Workload

PROJECT_TITLE: Digital Biomarkers of Movement, Emotional State, and Social Connectedness: clinically integrated tools to improve health equity in older patients with chronic pain


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: WESTPORT

ORG_NAME: LUNA BIOSCIENCE, INC.

ORG_STATE: CT

PHR: Narrative Leptospirosis is a globally important neglected spirochetal disease conservatively estimated to cause more than 1 million cases annually with a 5-20% case-fatality rate, significant morbidity, and with public and military health and economic consequences. There is currently no safe and effective leptospirosis vaccine for humans, yet there are both global and US domestic needs for one. This Phase I STTR application proposes experiments to advance VM protein-based leptospirosis vaccines into clinical development for humans.

PI_NAMEs: DEVILLERS, CARLA  (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Adjuvant;Adverse effects;Affect;Animal Model;Animal Testing;Animals;Antibodies;Antibody titer measurement;Antigens;Bacterial Vaccines;Biological Assay;Biological Markers;Biological Process;burden of illness;Canis familiaris;Case Fatality Rates;Cessation of life;Chemicals;Cholera;climate change;Clinical;clinical development;Clinical Trials;commercial application;commercialization;companion animal;Connecticut;Country;cross reactivity;Cytotoxin;Data;data modeling;Development;Disease;disulfide bond;Dose;Economics;Escherichia coli;Exotoxins;experimental study;extracellular;Fermentation;Frequencies;Genetic;Hamsters;Health;Human;Immune response;Immunity;immunogenicity;Immunoglobulin G;In Vitro;Incidence;Inclusion Bodies;Income;Infection;International;Kidney;Knowledge;Laboratories;Lead;Legal patent;Leptospira;Leptospira interrogans;Leptospirosis;Letters;Licensure;Liver;Livestock;low and middle-income countries;Measures;Mediating;Mediation;Military Personnel;Modeling;Molecular Conformation;Morbidity - disease rate;mortality;Mus;Mutate;neglect;novel;novel vaccines;Occupations;Organism;Outcome;Pathogenicity;Persons;Phase;pilot lot production;Prausnitz-Kustner Test;pre-clinical;prevent;primary outcome;Process;protective efficacy;Protein Family;protein purification;Proteins;prototype;Public Health;Publishing;Recombinant Proteins;Recombinants;Regimen;Regulatory Pathway;Reporting;Risk;Safety;Sanitation;Security;Severities;Small Business Technology Transfer Research;Structural Models;Technology;Testing;Time;Toxicology;Toxin;Toxoids;Typhoid Fever;Universities;Urbanization;Vaccination;vaccine access;Vaccine Antigen;vaccine candidate;vaccine development;vaccine trial;Vaccines;Virulence;Water;Work;Zoonotic Bacterial Infection

PROJECT_TITLE: Leptospirosis Vaccine Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-U(11)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative Vector-borne illnesses continue to be a source of worldwide morbidity and mortality, with ticks being the most important disease vector in the United States. In this proposal we will interrogate mechanisms that allow arthropods to harbor and transmit disease by building on our previous data and investigating the crosstalk between arthropod immunity and cellular stress responses, which functionally impact pathogen burden in ticks. Since microbial infections impart stress on host systems and cellular stress responses are well conserved across eukaryotes, we expect that our findings will uncover novel determinants of vector competence that are relevant to broad number of arthropod-pathogen systems.

PI_NAMEs: SHAW, DANA KATHLEEN (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Anaplasma phagocytophilum;Anaplasmosis;arboviral disease;Arthropod Vectors;Arthropods;Bacteria;biological adaptation to stress;Biology;Black-legged Tick;Borrelia burgdorferi;Case Study;Cell Line;Cells;Cellular Stress;comparative;Data;disease transmission;Disease Vectors;Drosophila genus;Drosophila melanogaster;Eukaryota;Event;Funding;Genes;Genetic Transcription;granulocyte;Growth;Host Defense;Human;Immune;Immune system;Immunity;immunodeficiency;Immunologic Receptors;In Vitro;in vivo;Infection;Infectious Agent;Insecta;Kinetics;knock-down;Knowledge;Label;Larva;Lyme Disease;Mediating;Membrane;Microbe;microbial;migration;model organism;Molecular;Morbidity - disease rate;mortality;Natural Immunity;novel;pathogen;pathogenic bacteria;Pathway interactions;Pattern;Pattern recognition receptor;pharmacologic;Process;Proliferating;Proteins;Research Personnel;response;RNA Interference;Role;Signal Transduction;Source;Stress;stressor;Study Section;System;Testing;tick transmission;tick-borne;Ticks;Tissues;TRAF2 gene;transcription factor;Transcriptional Activation;transmission process;United States;Universities;vector;vector competence;Vector-transmitted infectious disease;Washington

PROJECT_TITLE: Tick-Pathogen Interactions: Exploring the Intersection between Stress Responses and Immunity

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Gene Therapy;Genetics;HIV/AIDS;Immunotherapy;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Antiretroviral drugs can inhibit HIV infection, but cannot eliminate all the infected cells in the body that hide from the immune system. In order to cure HIV, we need to develop methods that accurately quantify the number of infected cells that remain hidden and explore new treatments that effectively target these HIV- infected cells. This project has scientific and public health relevance by deepening our understanding of how HIV remains hidden and ultimately uses this knowledge to develop curative strategies.

PI_NAMEs: KIM, JOCELYN T (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: adaptive immune response;Advisory Committees;Affect;Allogenic;Anti-Retroviral Agents;Antigens;antiretroviral therapy;Applications Grants;Autologous;Award;Baltimore;Bar Codes;Binding;Biology;Biomedical Engineering;Blood Cells;Blood donor;California;career development;Cell Therapy;Cells;Cellular Immunity;chimeric antigen receptor;chimeric antigen receptor natural killer cells;chimeric antigen receptor T cells;Chronic;Clinical;clinical application;Collaborations;combinatorial;Communicable Diseases;comparative efficacy;comparison control;Complex;Data;Disease Progression;Doctor of Philosophy;efficacy evaluation;efficacy testing;Funding;Gays;Gene Modified;Generations;Genetic;Genetic Enhancement;graft versus host disease induction;Hematopoietic stem cells;HIV;HIV Infections;HIV-1;humanized mouse;Immune system;In Vitro;in vitro Assay;in vivo;Innate Immune Response;innovation;Intention;Interruption;Knowledge;Measures;medical specialties;Mentors;Mentorship;Methods;Modeling;Molecular Cloning;Morbidity - disease rate;mortality;mouse model;Natural Killer Cells;neutralizing antibody;novel;novel therapeutics;Pathogenesis;Pathogenicity;Peripheral;peripheral blood;Peripheral Blood Stem Cell;Pharmaceutical Preparations;Physicians;Production;Productivity;Professional Competence;professor;programs;Protein Kinase C;Public Health;public health relevance;Reporter;Research;Research Personnel;Scientist;skills;Source;stem cell differentiation;synthetic protein;T cell differentiation;T-Lymphocyte;Technology;Testing;Therapeutic;tool;Training;Training Programs;Viral;viral rebound;Viral reservoir;Virus;Virus Diseases;Virus Replication;Writing

PROJECT_TITLE: The Effect of Natural Killer Cell-Based Therapy on the HIV Reservoir

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Defense against RNA viruses depends on tightly controlled innate immune signaling initiated by RIG-I-like receptors and transduced through the adaptor protein MAVS. This project will investigate how RNA molecules and RNA-binding proteins organize the signaling platform that forms around MAVS to promote antiviral signaling. The proposed work will uncover new RNA-centric principles by which immune signaling pathways are regulated and has the potential to reveal new therapeutic strategies against viral diseases as well as autoimmune disorders.

PI_NAMEs: GOKHALE, NANDAN SATISH (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: adaptive immune response;Adaptor Signaling Protein;Advisory Committees;antiviral immunity;Autoimmune Diseases;Biochemical;Bioinformatics;Biological Models;career;Co-Immunoprecipitations;combat;Complex;Coupled;Cytoplasmic Protein;Cytosol;Data;druggable target;Elements;Environment;experience;experimental study;Family;Fractionation;Future;Gene Expression;Goals;Immune;immune activation;Immune signaling;Immunologic Stimulation;Infection;Infection prevention;Inflammation;Inflammatory;Interferons;Mass Spectrum Analysis;Mediating;Membrane;Mentors;Microscopy;Mitochondria;Molecular;Natural Immunity;novel;novel therapeutic intervention;Optics;Organelles;Outcome;pathogenic virus;Pathway interactions;Pattern recognition receptor;Phase;Post-Translational Protein Processing;prevent;Process;Production;programs;protein complex;protein protein interaction;Proteins;Proteomics;receptor;Receptor Signaling;Regulation;Research;Research Personnel;response;Ribonucleases;Ribosomes;RNA;RNA Binding;RNA Viruses;RNA-Binding Proteins;RNA-Protein Interaction;Role;scaffold;Scientist;screening;Signal Pathway;Signal Transduction;Site;skills;Spliceosomes;Structure;Sucrose;TBK1 gene;Techniques;Testing;Therapeutic;Tissues;TNF receptor-associated factor 3;TRAF2 gene;Training;Universities;Viral;viral RNA;virology;Virus Diseases;Washington;Work

PROJECT_TITLE: Regulation of the MAVS Signalosome by RNA and RNA-binding Proteins

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE One-size-fits-all approaches have failed to demonstrate sustained effects on childhood obesity, especially among low-income minority families, who experience constantly changing barriers to engaging in health behavior. Addressing obesity in these populations requires intervening in early childhood and situating interventions in the context of families and communities. Developing personalized childhood obesity prevention interventions with sustained effectiveness that support families in health behaviors despite dynamic barriers could address chronic disease risk and health disparities in low-income and minority communities.

PI_NAMEs: HEERMAN, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: CLARK, DAVID

PROJECT_TERMS: 5 year old;Accelerometer;Address;adult obesity;Affect;Age;Area;Attention;Behavior;Behavior Therapy;Behavioral;Body mass index;Body Weight decreased;Child;Child Health;Child Rearing;Chronic Disease;Communities;community barrier;community building;community center;Community Health;comparison control;Competence;Control Groups;Cultural Sensitivity;Development;Diet;disorder risk;early childhood;early-onset obesity;Education;Educational Curriculum;Educational process of instructing;Effectiveness;Effectiveness of Interventions;effectiveness testing;Eligibility Determination;Enrollment;experience;Family;family support;flexibility;follow-up;food insecurity;Foundations;fruits and vegetables;Future;Generations;Goals;group intervention;Growth;Health;Health behavior;Health behavior change;health disparity;healthy weight;Heterogeneity;Hour;Household;improved;Individual;Infrastructure;Intervention;intervention effect;Latino;Low income;Measures;media use;Mediating;Minority;minority children;minority communities;Minority Groups;Modeling;Neighborhoods;novel;Obesity;obesity in children;obesity prevention;obesity treatment;Outcome;Parents;Participant;Pattern;personalized approach;personalized intervention;Phase;Physical activity;Population;preventive intervention;primary outcome;randomized trial;Randomized, Controlled Trials;Readiness;Reduce health disparities;scale up;Schools;secondary outcome;Self Determination;sex;Sleep;social health determinants;Structure;success;telephone coaching;Testing;theories;therapy design;treatment effect;Weight

PROJECT_TITLE: COACH:  Competency Based Approaches for Community Health


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health

PHR: Narrative Treatment response rates for social anxiety disorder are markedly lower than for other anxiety disorders, thus presenting an urgent need to identify novel therapeutic targets that can inform new interventions for this chronic, impairing, and difficult-to-treat disorder. In direct support of the NIMH Strategic Goal 3: Strive for Prevention and Cures, we propose to address this need by testing a developmentally-informed, mechanistic model of the escalation of impairing social anxiety symptoms in early-to-mid adolescence. Leveraging the expertise of our team in developmental psychopathology and experimental therapeutics, findings from this project will position us to pursue novel, developmentally-informed, brain-based therapeutics.

PI_NAMEs: BUZZELL, GEORGE ARTHUR (contact);PETTIT, JEREMY W

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: 15 year old;Acceleration;Address;Adolescence;Adolescent;Adolescent Development;Affect;Age;Anxiety;Anxiety Disorders;anxiety symptoms;anxious behavior;Back;Behavior;bench to bedside;Biological Markers;Brain;brain based;Chronic;Code;cognitive control;Data;Detection;Development;Disease;early adolescence;Electroencephalography;Ensure;Evaluation;Exhibits;Feedback;Feeds;Female;Female Adolescents;Fright;frontal lobe;Future;Goals;Impairment;improved;Intervention;Investigational Therapies;Lateral;Lead;Link;Longitudinal Studies;male;Measures;Medial;Mediating;Methods;Modeling;National Institute of Mental Health;neural;Neurocognitive;new therapeutic target;novel;Participant;Pathway interactions;Patient Self-Report;peer;Performance;Play;Population;Positioning Attribute;predictive modeling;Prevention;psychologic;Psychopathology;Puberty;recruit;response;Risk;Role;Self-Examination;self-reported anxiety;social;social anxiety;Social Anxiety Disorder;social cognition;Social Development;Social Environment;Social Interaction;social interventions;sociodemographics;System;Testing;Theoretical model;Therapeutic;Time;tool;Translating;treatment response;Work

PROJECT_TITLE: A developmentally-sensitive mechanism underlying the escalation of adolescent social anxiety

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Clinical Research;Hematology

PHR: Project Narrative Inﬂammation causes the release of oxidative agents, which activate blood coagulation proteins leading to a pro- thrombotic state. The work proposed here investigates the structural basis of how oxidation activates von Wille- brand factor, a key protein in the initial stages of blood coagulation. The results will help the structure-based design of therapeutics that are able to prevent thrombosis while minimizing the risk of unwanted bleeding.

PI_NAMEs: INTERLANDI, GIANLUCA  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute;Agglutination;Binding;Binding Sites;Biological Assay;Blood coagulation;Blood flow;Blood Platelets;Blood Proteins;Blood specimen;C-terminal;Chronic;Clinical;clinically relevant;Complement Factor D;Complex;Computing Methodologies;Dangerousness;design;Development;Disease;Docking;Drug Design;Endothelium;Environment;Equilibrium;Event;experimental study;Hemorrhage;Hemostatic Agents;Hemostatic function;In Vitro;in vivo;Inflammation;Inflammatory;insight;Knowledge;knowledge integration;Laboratories;Link;Mass Spectrum Analysis;Methionine;Methods;Modeling;Molecular Conformation;molecular dynamics;Mutagenesis;Mutation;N-terminal;Oxidants;oxidation;Pathologic;Patients;Physiological;prevent;Process;Proteins;receptor;Research;response;Risk;risk minimization;Risk Reduction;Ristocetin;Role;Sampling;Scanning;Sepsis;shear stress;side effect;Site;Structure;Surface;Testing;Therapeutic;therapeutic target;therapy development;Thrombosis;thrombotic;Thrombus;vascular injury;von Willebrand Factor;Work

PROJECT_TITLE: Differential targeting of von Willebrand factor depending on oxidizing conditions

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Cerebrovascular;Immunotherapy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: CINCINNATI

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project narrative Activation of the Wnt pathway appears to be part of a regulatory mechanism orchestrated by cells of the central nervous system to resolve inflammation and favor repair. The proposed project aims to demonstrate that inflammatory signals at the neurovascular level induce Wnt production by endothelial cells and astrocytes, which will regulate myeloid cell function and promote anti-inflammatory responses that support repair and limit neuropathology. This project will ultimately help in the design of new targets to stop the inflammation and stimulate remyelination in multiple sclerosis by understanding how to regulate myeloid APCs response.

PI_NAMEs: IFERGAN, IGAL  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Affect;Agonist;Animal Model;Anti-Inflammatory Agents;Antigen-Presenting Cells;Area;Astrocytes;beta catenin;Binding;Brain;brain endothelial cell;Cell Nucleus;Cell Physiology;Cell Surface Receptors;Cells;Central Nervous System;Chronic;Clinical;cytokine;Dendritic Cells;design;Disease;Disease remission;Endothelial Cells;Environment;Equilibrium;Experimental Autoimmune Encephalomyelitis;Exposure to;Genes;Genetic Transcription;Glycogen Synthase Kinases;Goals;Human;Immune;Immune response;Immune system;immunoregulation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Interleukin-10;Interleukin-12;interleukin-23;Interleukin-6;Lesion;Ligands;Mediating;monocyte;Multiple Sclerosis;Mus;Myelin;Myelogenous;Myeloid Cells;neuroinflammation;neuropathology;neurotoxic;neurovascular;neurovascular unit;Pathologic;Pathway interactions;Peripheral Nervous System;Phosphorylation;Phosphotransferases;Play;Production;programmed cell death ligand 1;Relapse;remyelination;repaired;Resolution;response;Role;Severities;Signal Transduction;Structure;T-Lymphocyte;Transcript;Wnt proteins;WNT Signaling Pathway

PROJECT_TITLE: Role of the neurovascular molecule Wnt in regulating CNS inflammatory responses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Lung;Pulmonary Hypertension;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Remodeling of blood vessels is a critical component of diverse vascular diseases. Recently, we  identified a pool of specialized progenitors in the walls of vessels in the lung that play a  critical role in this pathological remodeling, and initial studies suggest similar processes in  atherosclerosis. The proposed investigations characterize these progenitor pools, delineate the  mechanisms underlying their regulation in the context of vascular disease and thereby, facilitate  the development of novel therapeutic strategies.

PI_NAMEs: GREIF, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Aorta;Arteries;arteriole;Atherosclerosis;Blood Vessels;Bone Marrow;Cell Separation;cell type;Cells;Clonal Expansion;Development;Disease;Distal;Endothelial Cells;Gene Expression;GKLF protein;Human;human tissue;Hypoxia;insight;Investigation;Ligands;Location;Lung;Macrophage;Maintenance;Mesenchyme;migration;Molecular Profiling;Morphogenesis;mouse model;Mus;Muscle;muscle progenitor cell;Myeloid Cells;novel;novel therapeutic intervention;Pathogenesis;Pathologic;Pathology;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor beta Receptor;Play;pluripotency factor;Process;progenitor;programs;Pulmonary Hypertension;recruit;Regulation;Research;Role;Seminal;Smooth Muscle;Smooth Muscle Myocytes;stem cells;Therapeutic;Tunica Media;Undifferentiated;Vascular Diseases;Vascular Smooth Muscle;Work

PROJECT_TITLE: Novel vascular smooth muscle cell progenitors in development and disease


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MINNEAPOLIS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Biostatistics is indispensable in the design, implementation and analysis of biomedical and public health studies. As a result, training of the next generation scientists with expertise in biostatistics is crucial to the ongoing health of the nation's biomedical research enterprise. In this application, we request stipend, tuition, and limited travel support for the interdisciplinary training of predoctoral students in biostatistics and genetics/genomics for five years.

PI_NAMEs: BASU, SAONLI  (contact);PAN, WEI

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Biostatistics in Genetics and Genomics Training Program

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Overall Project Narrative As a basic science cancer center, the Purdue University Center for Cancer Research (PCCR), through its fundamental research effort, serves its state, country and the world through innovative discovery and its application to develop cancer solutions. Through drug discovery, drug delivery, imaging technology and biomarker discovery, the PCCR applies innovative solutions to major cancer problems.

PI_NAMEs: MESECAR, ANDREW D (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Animal Cancer Model;anti-cancer research;Basic Science;Biological;Biological Sciences;biomarker discovery;Cancer Biology;cancer biomarkers;cancer cell;Cancer Center;Cancer Center Support Grant;Canis familiaris;Cell Physiology;Cells;Characteristics;chemical reaction;Chemicals;Chemistry;Clinical Cancer Center;collaborative environment;college;Comprehensive Cancer Center;Country;Development;diagnostic development;diagnostic tool;Discipline;Drug Delivery Systems;Drug Design;drug development;drug discovery;Engineering;Environment;Evaluation;Flow Cytometry Shared Resource;Fostering;Foundations;fundamental research;Future;genome editing;Genomics Shared Resource;imaging biomarker;Imaging Device;Imaging technology;in vivo;Infrastructure;innovation;Institution;Interferometry;ionization;Leadership;Malignant Neoplasms;Mass Spectrum Analysis;member;Mission;Molecular;Molecular Structure;Monitor;Motility;Motion;NCI Center for Cancer Research;NCI-Designated Cancer Center;novel;Nucleic Acids;Nutritional Science;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacy facility;physical science;Positioning Attribute;Process;programs;Proliferating;Proteins;Public Domains;Research;research clinical testing;Research Personnel;Resource Sharing;Services;Signal Transduction;structural biology;Structure;System;Technology;Therapeutic;therapeutic development;Transgenic Organisms;Universities;Validation;Veterinary Medicine

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: CUTTELL, DOUGLAS GRANT (contact)

PROJECT_TERMS: anti-cancer research;Applications Grants;Basic Science;Biological Sciences;Cancer Center;Cancer Center Support Grant;Chemistry;data management;Decision Making;Discipline;Elements;Engineering;Fostering;Foundations;Grant;improved;Informatics;Information Technology;innovation;Institution;Leadership;Malignant Neoplasms;meetings;Mission;Monitor;National Cancer Institute;NCI Center for Cancer Research;Nutritional Science;operation;Pharmacy facility;physical science;Pilot Projects;Process;programs;Research;Resource Sharing;Strategic Planning;structural biology;Universities;Veterinary Medicine

PROJECT_TITLE: Cancer Center Administration


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The proposed research is relevant to public health because it focuses on advancing the detection and characterization of prostate cancer by developing reproducible and repeatable quantitative MR imaging methods. Once proposed technologies have been developed, they have potentials to provide an objective identification and classification of prostate cancer, thus reducing unnecessary biopsies and facilitating appropriate treatment selection. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to improving the diagnosis of human diseases.

PI_NAMEs: JIANG, YUN  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Adoption;aggressive therapy;Benign;Biopsy;Cancer Detection;Classification;clinically significant;Core Biopsy;Data;Detection;Diagnosis;Diffusion;Discrimination;Disease;Epithelium;experience;Fingerprint;Gland;Goals;human disease;Image;imaging approach;imaging detection;imaging modality;improved;Indolent;innovation;Lead;Lesion;Life;Magnetic Resonance;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurement;Methods;millimeter;Mission;Morbidity - disease rate;Pathologic;Pathology;Pathway interactions;Patients;Performance;Positioning Attribute;Process;Property;Prostate;Protocols documentation;Public Health;quantitative imaging;Radical Prostatectomy;reconstruction;Reproducibility;Research;Resolution;Sampling;Scanning;Screening for Prostate Cancer;Selection for Treatments;Sepsis;Signal Transduction;standard of care;Standardization;Structure;T2 weighted imaging;Technology;Testing;Time;Tissues;ultrasound;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: 3D High Resolution Magnetic Resonance Fingerprinting for Prostate Cancer

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


PI_NAMEs: TEEGARDEN, DOROTHY  (contact)

PROJECT_TERMS: Address;anti-cancer research;Awareness;Basic Science;Big Data;Bioinformatics;Cancer Center Support Grant;career;Career Choice;Clinical;Communities;Community of Practice;design;Development;Discipline;Education;Educational Status;Event;experience;Faculty;fighting;Fostering;Funding;Future;Goals;graduate student;high school;Home;Individual;innovation;Institution;Journals;Laboratories;Leadership;Malignant Neoplasms;member;Mind;Mission;Nature;physical science;Population;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;recruit;Research;Research Personnel;Resource Sharing;Resources;Running;Scientist;Shapes;Students;summer research;supportive environment;Teacher Professional Development;tool development;Training;Training and Education;training data;Training Programs;undergraduate education;undergraduate research;undergraduate student;Underrepresented Minority;Underrepresented Students;Work

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: The germinal center reaction generates high quality humoral memory to protect us from infection but can also be involved in diseases such as autoimmunity and allergy. This project is relevant to public health because it aims to elucidate the underlying mechanisms of how the generation of immune memory from GC is regulated. These mechanistic insights are likely to provide novel strategies to therapeutically manipulate germinal center response for improving vaccine efficacy and treating allergy and autoimmune diseases. 1

PI_NAMEs: LUO, WEI  (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: activation-induced cytidine deaminase;Adoptive Transfer;Affect;Affinity;Allergic Disease;anergy;Antibodies;Autoimmune Diseases;Autoimmunity;B cell differentiation;B-Cell Development;B-Lymphocytes;Biological Process;Bone Marrow;c-myc Genes;CD19 gene;Cell Communication;Cells;Coupled;Data;Development;Disease;Down-Regulation;Enterobacteria phage P1 Cre recombinase;Face;FRAP1 gene;Generations;Genes;Goals;Homologous Protein;Hypersensitivity;Immune response;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Switch Recombination;Immunologic Memory;Impairment;improved;in vivo;inducible Cre;Infection;Inositol;insight;knock-down;Knowledge;Lipids;Maintenance;Memory;Memory B-Lymphocyte;Metabolism;Molecular;novel;novel strategies;pathogen;Pathogenicity;Pathway interactions;PIK3CG gene;plasma cell differentiation;Plasma Cells;prevent;protein expression;Proto-Oncogene Proteins c-akt;PTEN gene;Public Health;Reaction;Recycling;Regulation;response;Role;Signal Pathway;Signal Transduction;Structure of germinal center of lymph node;System;Testing;Therapeutic;transcriptomics;Vaccination;vaccine efficacy

PROJECT_TITLE: The role of PTEN signaling in regulating germinal center B cell fate decision

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


PI_NAMEs: TESMER, JOHN  (contact)

PROJECT_TERMS: Address;anti-cancer therapeutic;Antineoplastic Agents;Binding Sites;Biological Process;Cancer Center Support Grant;Chemical Structure;Complex;computerized data processing;computing resources;Consultations;cost;Cryoelectron Microscopy;Crystallization;Data Collection;Dedications;design;detector;Development;Disease;drug development;drug discovery;Electrons;Equipment;experience;experimental study;Funding;Image;Image Analysis;Individual;instrument;Ligand Binding;macromolecular assembly;Macromolecular Complexes;macromolecule;Malignant Neoplasms;Medicine;member;Mission;Modality;Molecular;Molecular Structure;multidisciplinary;NCI Center for Cancer Research;NMR Spectroscopy;particle;Peer Review;Pharmaceutical Preparations;programs;Protein Dynamics;rational design;Research;research faculty;Resolution;Resource Sharing;Resources;robotic system;Roentgen Rays;Route;Services;small molecule;Structural Biologist;structural biology;Structure;Techniques;Technology;Temperature;Therapeutic Agents;Time;tool;Training;Universities;Walking;X-Ray Crystallography

PROJECT_TITLE: Biomolecular Structure SR (BS-SR)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: RELEVANCE (See instructions): Ensuring that machine learning tools are demographically fair, even in settings where no direct evaluation can be performed, will further promote the monitoring of machine learning models for fairness in real-world practice of relevance for public health policy generally, and for large scale cancer screening programs in particular. The project includes a series of broader impact activities focused in promoting under-represented groups in science and engineering and dissemination.

PI_NAMEs: SULAM, JEREMIAS  (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: access disparities;Address;Age;algorithmic bias;Algorithms;Anatomy;Area;Artificial Intelligence;artificial neural network;Binding;biological sex;Breast Cancer Detection;breast imaging;cancer diagnosis;cancer imaging;Certification;Chest imaging;Clinical/Radiologic;clinically relevant;Complex;Data;Data Set;deep neural network;demographics;Development;Diagnosis;diagnostic accuracy;Diagnostic Imaging;diagnostic tool;Disease;disease classification;Disparity;disparity reduction;Engineering;Ensure;Ethics;Evaluation;Explosion;Future;Generations;Health;health disparity;Health Policy;high risk;Image;imaging modality;improved;Individual;Instruction;Knowledge;Location;lung cancer screening;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Malignant Breast Neoplasm;Malignant neoplasm of lung;Measures;Medical center;Medical Imaging;Medicine;Methodology;Methods;Modernization;Monitor;novel;Outcome;Performance;Population;population based;prediction algorithm;predictive modeling;prevent;Procedures;Proxy;Public Health Applications Research;public health relevance;Race;Radiology Specialty;real world application;Recommendation;Research;Sampling;Science;screening;Screening for cancer;Screening procedure;screening program;Series;System;Technology;Thoracic Radiography;Time;tool;Training;training data;Underrepresented Populations;Validation

PROJECT_TITLE: SCH: Quantifying and mitigating demographic biases of machine learning in real world radiology