NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: SHULTZ, LEONARD  (contact)

PROJECT_TERMS: Abbreviations;animal care;Animal Husbandry;animal resource;anti-cancer research;Biology;Breeding;Cancer Center;Cancer Center Support Grant;Cancer Model;Collaborations;Complex;Consultations;Coupled;design;Development;Developmental Biology;Discipline;Engineering;Engraftment;experience;experimental study;Faculty;Gene Modified;Generations;Genetic Engineering;genetic manipulation;genetic resource;Genetic Variation;Genetically Engineered Mouse;Genome;Goals;Grant;humanized mouse;improved;Infrastructure;Institution;interest;Laboratories;Libraries;Maintenance;Malignant Neoplasms;Maps;member;model development;Modeling;Modification;Molecular;Molecular Biology;mouse genetics;mouse model;Mus;Names;neoplasm resource;Neurobiology;novel;patient derived xenograft model;Performance;Phenotype;Play;Primary Neoplasm;Process;Recording of previous events;repository;Reproductive Biology;Research;research and development;Research Personnel;Resource Development;Resource Sharing;Resources;Role;Science;Services;single cell technology;skills;Technical Expertise;Technology;tool;Validation;virtual

PROJECT_TITLE: Cancer Models Development Shared Resource


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: BAR HARBOR

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PI_NAMEs: ADAMS, MARK D (contact)

PROJECT_TERMS: Abbreviations;Address;Archives;Area;Automation;Automobile Driving;Binding;Biological Assay;Biology;Cancer Biology;cancer cell;Cancer Center;cancer genome;cancer genomics;cancer therapy;Cells;Cellular biology;Chromatin Structure;Collaborations;community center;Complement;Complex;Computational Science;cost;Cytometry;Data;Data Analyses;data management;Data Management Resources;Dideoxy Chain Termination DNA Sequencing;Dimensions;Dissociation;DNA;DNA Modification Process;DNA sequencing;Educational workshop;Ensure;Epigenetic Process;epigenome;epigenomic profiling;epigenomics;Experimental Designs;Faculty;Funding;Generations;Genetic;Genome;genome analysis;Genomic Instability;genomic profiling;Genomics;Goals;graduate student;Grant;Heterogeneity;host neoplasm interaction;Image;improved;Individual;Infrastructure;Institution;intercellular communication;Investments;Laboratories;Libraries;liquid biopsy;Malignant Neoplasms;Management Information Systems;meetings;member;Metadata;Methods;Microfluidics;Modification;Molecular;Molecular Biology;Names;NCI Center for Cancer Research;novel sequencing technology;nucleic acid purification;operation;Phenotype;Positioning Attribute;Postdoctoral Fellow;Process;programs;Proteins;Protocols documentation;Regulation;Research;Resistance;Resolution;Resource Development;Resource Sharing;Resources;RNA;Sampling;Scientist;service programs;Services;single cell technology;single molecule;Specificity;Structure;System;Systems Analysis;technological innovation;Technology;Testing;The Jackson Laboratory;Time;Tissues;tool;Toxic effect;Training;Training and Education;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;tumor;Tumor Biology;tumor DNA;tumor heterogeneity;tumor microenvironment;Variant;whole genome

PROJECT_TITLE: Genome and Single Cell Technologies Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Pediatric;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Most young adult (<30 years old) people who inject drugs (PWID) –who are the group at greatest risk for hepatitis C virus (HCV) infection—do not initiate available curative therapy. Building on our extensive foundation of dyadic research and dyadic behavior change theories, we developed the Partner Navigation Intervention a two-session injecting partnership intervention to enhance dyadic capacity for HCV treatment initiation for young adult PWID. The proposed study is a randomized controlled study (RCT) to assess the efficacy and mechanism of action of the first behavioral intervention to increase HCV treatment initiation among young adult PWID.

PI_NAMEs: MORRIS, MEGHAN D (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: acceptability and feasibility;Action Potentials;Address;Adult;Affect;Age;Behavior;behavior change;Behavior Therapy;Clinical;clinical diagnosis;cohort;Communities;community advisory board;comparison intervention;Control Groups;Counseling;County;curative treatments;Data;design;Diagnosis;Discrimination;Dissemination and Implementation;distrust;efficacy evaluation;efficacy testing;Emotional;Epidemic;Evidence based program;experience;Family;Foundations;Friends;Goals;group intervention;Health;Health behavior;Health behavior and outcomes;Health Promotion;Health Resources;Hepatitis C;Hepatitis C Therapy;Hepatitis C virus;Homelessness;improved;indexing;Individual;Infection;Injecting drug user;Intervention;Intervention Studies;intimate behavior;Maps;marginalization;Medical;member;novel;opioid epidemic;Paper;Partnership Practice;Personal Satisfaction;Persons;Population;Poverty;Prevention;Probability;Professional counselor;programs;Randomized;randomized trial;randomized, controlled study;Records;Research;response;Risk;Role;Safety;San Francisco;Site;social;Social Network;social relationships;Social support;standard of care;success;System;Testing;Theory of Change;Time;timeline;tool;Translating;Trust;United States;Visit;Work;young adult

PROJECT_TITLE: A Randomized Trial to Test the Efficacy of a Partner Navigation Intervention for HCV Treatment among Young Adult People who Inject Drugs

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


PI_NAMEs: LUTZ, CATHLEEN M (contact)

PROJECT_TERMS: Abbreviations;Alleles;animal care;Animals;anti-cancer research;assay development;biosecurity;Cancer Center;Cancer Model;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Conceptions;Consultations;cost effective;design;Development;embryonic stem cell;empowerment;Engineered Gene;Engineering;Ensure;experience;Experimental Designs;gene editing technology;gene function;Gene Modified;Gene Transfer Techniques;Genes;Genetic;Genetic Engineering;genetic manipulation;genetic technology;genetic variant;Genetically Engineered Mouse;Genome engineering;Genotype;Germ Lines;Grant;In Vitro;in vivo;Inbreeding;instrumentation;Laboratories;Laboratory Research;Lead;Leadership;Mammalian Cell;medical specialties;member;Methods;Microinjections;Modeling;Modernization;Modification;Molecular;mouse genome;mouse model;Mouse Strains;Mus;mutant;Mutation;Names;next generation;novel;Preparation;Process;Production;Reagent;reagent testing;recombinant virus;Reporting;Reproductive Biology;Research Personnel;Resource Development;Resource Sharing;Resources;Services;Specialist;Study models;success;targeted nucleases;Technical Expertise;Technology;Testing;tool;Training;Transgenes;Validation;Viral Vector;Virus Diseases;Work;zygote

PROJECT_TITLE: Genetic Engineering Technologies Shared Resource


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: SAN LUIS OBISPO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CALIFORNIA POLY STATE U SAN LUIS OBISPO

PHR: PROJECT NARRATIVE The persistent lack of diversity among scientists in the biomedical field inhibits our ability to effectively address the complex array of health problems and disparities that affect our nation and the world today. U-RISE at Cal Poly is a training program that incorporates best practices from evidence-based training programs, providing underrepresented undergraduate students the experiences needed to pursue a biomedical, research-focused graduate degree. The multi-faceted program includes mentored research experiences, didactic instruction on conceptual and technical research skills, mentoring teams, and specialized curriculum emphasizing the prosocial value of biomedical research, building identity as a scientist, fostering a deep understanding of health equity, and developing knowledge and skills to direct research towards current health challenges.

PI_NAMEs: HAGOBIAN, TODD ALAN (contact);KEADLE, SARAH KOZEY

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Affect;Biomedical Research;career;design;Development;Development Plans;Disabled Persons;Economically Deprived Population;equity, diversity, and inclusion;Ethics;Event;evidence base;experience;Faculty;Future;Graduate Degree;Graduate Education;graduate school;Health;improved;Individual;Infrastructure;Knowledge;Mentors;novel;Pathway interactions;people of color;Perception;programs;Research;Science;Scientist;Self Efficacy;skill acquisition;socioeconomic disadvantage;Structure;Students;success;Technical Expertise;Training Programs;Underrepresented Populations;Underrepresented Students

PROJECT_TITLE: U-RISE at Cal Poly

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: NORFOLK

ORG_DEPT: CHEMISTRY

ORG_NAME: OLD DOMINION UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The goal of our proposal is to increase the diversity of students pursuing a Ph.D. in a STEM field and a research career in biomedical research. To achieve this goal, we have developed a series of activities for high achieving underrepresented students; activities that are designed to facilitate the development of their talent and professional skills in preparation for excelling in their subsequent Ph.D. or Ph.D./M.D. programs and careers in science areas that have biomedical relevance, while contributing to our understanding of minority health disparities and other key issues.

PI_NAMEs: HOLDER, ALVIN ANDERSON (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academic Training;Advisory Committees;Behavioral;Biomedical Research;career;cohort;college;Communication;Computer software;Critical Thinking;Development;Doctor of Philosophy;Engineering;experience;Faculty;faculty mentor;Feedback;Fellowship;Funding;Graduate Education;graduate school preparation;GRE Preparation;Health Sciences;Institution;Instruction;Journals;K-Series Research Career Programs;Laboratories;laboratory equipment;Laboratory Research;Leadership;Learning;Letters;Literature;member;Mentors;Mentorship;operation;Peer Review;Performance;Process;programs;Publications;recruit;Research;Research Training;responsible research conduct;Science;skills;STEM research;Students;Support System;symposium;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Populations;Universities;Work;Writing

PROJECT_TITLE: U-RISE at Old Dominion University

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SUNDBERG, JOHN PAUL (contact)

PROJECT_TERMS: Abbreviations;Aging;Anatomy;Animals;Autopsy;Benchmarking;Biochemical;Biological Models;Biometry;Blood Chemical Analysis;Budgets;Cancer Center;Cancer Model;Capital;Capital Financing;cell preparation;Cell surface;Cells;Certification;Characteristics;Chemicals;Chemistry;Clinical assessments;Collection;Consultations;cost;cost comparison;Data;Education;Educational workshop;Electron Microscopy;Ensure;Equipment;experience;Experimental Designs;Flow Cytometry;Fresh Tissue;Funding;Genetic;Genomics;Goals;Grant;Health Services Accessibility;Hematology;Histology;Histopathology;Image;Individual;innovation;Institution;instrument;instrumentation;Laboratories;Learning;Link;Mass Spectrum Analysis;member;Microscopy;Modernization;Mus;Names;NON Mouse;peer;Phenotype;Physiological;Price;Process;programs;Protein Analysis;Protein Chemistry;Proteins;Qualifying;Quality Control;Research Project Grants;Resolution;Resource Sharing;Resources;Sampling;Science;Services;Site;skills;Structure;success;symposium;Technology;Time;tissue preparation;Tissues;tool;Training;tumor;whole animal imaging;Work

PROJECT_TITLE: Phenotyping Technologies Shared Resource


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: The state-of-the-art in practical efficient and stereocontrolled preparation of glycosidic bonds lags far behind that for peptide and oligonucleotide synthesis and consequently seriously hinders the study of the biology of oligosaccharides and their conjugates. This proposal sets out two develop two new photochemical technologies for glycosidic bond formation, with the emphasis on simplicity and ease of operation such as will be required if synthetic glycans are to be made routinely available to the Glycoscience community.

PI_NAMEs: CRICH, DAVID  (contact);POPIK, VLADIMIR V

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TITLE: Photochemical Technologies for Improved Glycosylation Reactions

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Precision Medicine

PI_NAMEs: ANCZUKOW-CAMARDA, OLGA  (contact)

PROJECT_TERMS: Abbreviations;Adverse effects;Animal Model;anti-cancer research;Antigen-Presenting Cells;Area;Basic Science;behavioral response;Biological;Biological Models;Biological Process;biological systems;biomarker validation;Budgets;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer genomics;Cancer Model;cancer therapy;Cancer Vaccines;candidate marker;Cell model;chemotherapy;Chromosomal Rearrangement;Cities;Clinical;Collaborations;Complex;Computational algorithm;Computational Science;Computer Models;Computing Methodologies;computing resources;Connecticut;Data Set;design;Development;Direct Costs;Discipline;DNA Damage;DNA Repair Pathway;DNA Sequence Alteration;Evolution;Extracellular Matrix;Faculty Recruitment;Fostering;Foundations;functional genomics;Funding;Future;Genetic;Genetic Engineering;Genetic Models;genetic resource;Genetic Variation;Genome;genomic aberrations;Genomic Instability;Genomics;Goals;Grant;Health;Immune checkpoint inhibitor;Immunodeficient Mouse;Immunologics;Immunotherapy;in vitro Model;in vivo;in vivo Model;innovation;innovative technologies;Investigation;Israel;Knowledge;Laboratories;Leadership;Maine;Malignant Neoplasms;Mediator;Medical center;Medicine;meetings;member;Methods;model development;Modeling;Mus;Mutation;Names;NCI Center for Cancer Research;neoplastic cell;new technology;novel;Oncogene Activation;Output;patient derived xenograft model;Patients;Pediatric Hospitals;Peer Review;Phenotype;precision medicine;precision oncology;programs;Property;Proteins;Publications;Records;Research;Research Personnel;Research Project Summaries;Research Support;Resistance;resistance mechanism;Resource Development;Resources;response;Sampling;Shapes;single cell technology;Southwest Oncology Group;System;technological innovation;Technology;technology platform;Telomere Maintenance;The Jackson Laboratory;therapeutic target;therapy resistant;translational potential;Travel;treatment response;tumor;Tumor Suppressor Proteins;Tumorigenicity;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Research Program


ADMINISTERING_IC: MD

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The vast majority of research on environmental health disparities for air pollution, as well as the health effects of ambient air pollution more generally, has been conducted in cities; similarly, research on the health consequences of exposure to low or high temperatures, especially for heat waves, has almost exclusively focused on the urban environment and urban heat island effects. The people, communities, air pollution sources and mixtures, and adaptive capacities to extreme heat and cold may differ in rural settings, such that current strategies (i.e., federal air quality regulations) may not adequately protect rural populations, although these populations have poorer health outcomes, and limited research suggests that racial health disparities may be even larger in rural compared to urban areas. This project will provide scientific evidence on the disproportionate impacts of air pollution and extreme temperature in the rural south, with a focus on Virginia and West Virginia, including rural racial and ethnic minority groups, with an understanding of the range of rural forms and the intersection of multiple health disparity populations (e.g., race/ethnicity, socio-economic status).

PI_NAMEs: BELL, MICHELLE L (contact);DEZIEL, NICOLE

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Accounting;Address;adverse birth outcomes;Affect;Air Pollutants;Air Pollution;air quality regulation;ambient air pollution;Appalachian Region;Architecture;Area;Behavior;Birth;Black, Indigenous, People of Color;Cities;cold temperature;Communities;community-level factor;Congenital Abnormality;Data;Databases;Development;Disparity;Education;Environmental Exposure;Environmental Hazards;Environmental Health;environmental health disparity;environmental justice;ethnic minority population;Ethnic Origin;experience;Exposure to;extreme heat;extreme temperature;fine particles;Goals;Health;health care availability;health disparity populations;health economics;Health Policy;Health protection;heat island;Heat Waves;Heterogeneity;High temperature of physical object;Hospitalization;Income;Individual;Infant;intersectionality;Intervention;Knowledge;Life Expectancy;Link;Low Birth Weight Infant;low socioeconomic status;Medicare;Methods;Morbidity - disease rate;mortality;Municipalities;National Institute on Minority Health and Health Disparities;Nitrogen Dioxide;Older Population;Outcome;Ozone;Persons;pollutant;Pollution;poor health outcome;Population;Population Density;Population Sizes;Predisposition;Premature Birth;Public Health;Race;racial health disparity;racial minority;racial minority population;Regulation;Research;Resources;response;Role;Rural;rural area;Rural Community;rural dwellers;rural environment;Rural Health;Rural Minority;Rural Population;rural setting;rurality;Science;Socioeconomic Status;socioeconomics;Source;stressor;United States Environmental Protection Agency;United States National Institutes of Health;urban area;Urban Population;urban setting;Urbanicity;Variant;Virginia;Weather;West Virginia

PROJECT_TITLE: Air Pollution, Heat, Cold, and Health: Disparities in the Rural South

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


PI_NAMEs: PALUCKA, ANNA KAROLINA  (contact)

PROJECT_TERMS: Abbreviations;Acute Myelocytic Leukemia;Award;Basic Science;Cancer Center;cancer genome;cancer genomics;Cancer Model;Chronic Lymphocytic Leukemia;Clinical;Data;Development;Direct Costs;Epithelial ovarian cancer;Epithelium;Faculty;Fostering;Funding;Future;Genomics;Goals;Grant;Growth;Hematopoietic stem cells;Human;Human Genetics;human genomics;Immunooncology;in silico;in vivo;innovation;Institution;interdisciplinary collaboration;Laboratories;Leadership;Malignant Neoplasms;member;Mentors;Mesenchymal;Modeling;Mus;Names;novel;Pilot Projects;precision oncology;Productivity;professor;programs;Publications;recruit;Request for Applications;Research;Research Personnel;Resource Sharing;Science;Secure;Services;Shapes;Source;System;Systems Biology;technological innovation;The Jackson Laboratory;tool;tumor microenvironment;Validation;Work

PROJECT_TITLE: Developmental Funds


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_DEPT: GENETICS

PHR: Humans exhibit many physical differences compared to other species, which are ultimately due to genetic changes in our evolution that altered how our body develops. Our goal is to understand the effects of these changes during development using mouse models. The results of our studies will reveal how genetic variation modified developmental processes in humans, providing novel insight into both conserved and unique mechanisms of human development.

PI_NAMEs: NOONAN, JAMES P (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Animal Model;Architecture;Binding;biochip;Biological Process;Cell Physiology;cell type;Cells;Cerebral cortex;ChIP-seq;Chondrocytes;chromosome conformation capture;cognitive ability;Coupled;CRISPR/Cas technology;Data;data integration;Development;developmental disease;Developmental Gene;Developmental Process;Digit structure;Elements;Embryo;Enhancers;Epigenetic Process;epigenetic profiling;Evolution;Exhibits;Experimental Models;Funding;gain of function;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Genetic Variation;Genome;genome editing;genome-wide;Goals;Growth;Human;Human Development;Human Genetics;human tissue;humanized mouse;in vivo;innovation;insight;Length;Limb Bud;Limb Development;Limb structure;Macaca mulatta;Maps;Modeling;Molecular;Morphogenesis;Morphology;mouse model;Mus;Mutation;novel;Orthologous Gene;Pan Genus;Pattern;Phenotype;Play;Regulatory Element;Regulatory Pathway;Research Project Grants;Resolution;Role;single cell ATAC-seq;single-cell RNA sequencing;skeletal;Specific qualifier value;temporal measurement;Time;tool;trait;transcription factor;transcriptome;Walking;Wild Type Mouse

PROJECT_TITLE: Modeling uniquely human developmental gene regulatory networks using humanized mice

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE This proposal focuses on understanding the mechanisms of pancreatic β-cells senescence and the optimal strategy to therapeutically target them. Cell autonomous and non-cell autonomous mechanisms will be studied in biologically relevant models such as primary human and rodent islets. Achievement of the proposed aims will advance our knowledge of senescence biology in a highly metabolically relevant cell type with important implications for type 2 diabetes mellitus.

PI_NAMEs: TSENG, YU-HUA  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: 3-Dimensional;Ablation;Achievement;Adipocytes;Adipose tissue;Adrenergic Agents;Adrenergic Receptor;Affect;Architecture;Area;ATAC-seq;ATP Synthesis Pathway;Binding;Bioenergetics;Bioinformatics;Biology;Brown Fat;Cardiometabolic Disease;Cardiovascular Diseases;Cell Aging;Cell Nucleus;Cell Respiration;cell type;Cells;ChIP-seq;Chromatin;Chromatin Loop;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;comparative;Complex;computerized tools;CRISPR screen;CRISPR/Cas technology;current pandemic;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Data;Deposition;Distal;Elements;Energy Metabolism;Enhancers;Epigenetic Process;epigenetic regulation;Event;Fatty acid glycerol esters;Gene Expression;Genes;Genetic Transcription;Genome Mappings;genome-wide;genomic data;Genomics;Histones;Human;Impairment;improved;in vivo;islet;Knockout Mice;Knowledge;LIM Domain;Low Prevalence;Malignant Neoplasms;MAP Kinase Gene;Maps;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;Molecular;Morbidity - disease rate;mortality;mRNA Expression;Mus;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nuclear Translocation;Obesity;overexpression;Oxidative Phosphorylation;p38 Mitogen Activated Protein Kinase;Pathology;Persons;phosphoproteomics;Phosphorylation;Phosphorylation Site;Physiological;Physiological Processes;Play;Positioning Attribute;Post-Translational Protein Processing;prevent;Process;programs;promoter;Promoter Regions;protein expression;Proteins;Receptor Signaling;recruit;Regulation;Reporting;Resolution;response;Risk Factors;RNA;RNA Polymerase II;Rodent;Role;Scheme;senescence;severe COVID-19;Signal Induction;Signal Pathway;Signal Transduction;Site;Site-Directed Mutagenesis;Structure of beta Cell of islet;System;Techniques;Testing;Therapeutic;therapeutic target;Thermogenesis;Trans-Activators;transcription factor;Transcriptional Regulation;transcriptome sequencing;Triglycerides;uncoupling protein 1;United States;Variant;Zinc Fingers

PROJECT_TITLE: Transcriptional and epigenetic regulation of thermogenic adipocyte program

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Public Health Relevance: We have identified important roles for the ABC transporter ABCG2 in the most difficult to treat Medulloblastoma, Group 3. Our preliminary studies have identified a novel mechanism based ABCG2 inhibitor. These investigations will demonstrate how this inhibitor disrupts ABCG2 function as well as showing how this strategy can enhance chemotherapeutic efficacy against Group 3 Medulloblastoma.

PI_NAMEs: SCHUETZ, JOHN D (contact)

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: ABCG2 gene;Adult;Affect;Amino Acids;ATP-Binding Cassette Transporters;Binding;Blood - brain barrier anatomy;blood-brain barrier penetration;blood-brain tumor barrier;Brain Neoplasms;Cell Line;Cell membrane;Cells;Central Nervous System;Central Nervous System Neoplasms;Cerebellar Neoplasms;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Child;Childhood Malignant Brain Tumor;Combination Drug Therapy;comparative efficacy;Coupled;Data;Disease;Drug usage;effective therapy;Elements;Excision;flotillin;Genes;Genetic;Goals;human disease;Image;improved;inhibitor;Investigation;Knowledge;Ligands;loss of function;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Maps;Medication Systems;Medulloblastoma;Membrane;Membrane Microdomains;Modeling;Molecular;mouse model;Mus;Mutagenesis;Mutate;Non-accidental;novel;Pathway interactions;Pharmaceutical Preparations;pharmacophore;pre-clinical;Prognosis;Prognostic Factor;Proteins;Proteomics;public health relevance;Refractory;Reporting;Retrieval;Role;screening;Secondary to;Signal Transduction;Small Interfering RNA;Testing;Therapeutic;therapeutic effectiveness;Treatment Efficacy;tumor;whole genome

PROJECT_TITLE: Transporters and Medulloblastoma

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative  Acute myeloid leukemia (AML) is one of the most common and fatal forms of hematological malignancies. Here, we will uncover a novel role of RBM33 in m6A RNA demethylation, and define the important role of RBM33 in AML development and maintenance as well as leukemia stem cell self-renewal. This study will significantly advance our understanding of the complex mechanisms underlying the m6A modification-mediated gene regulation and the critical role of m6A modification in leukemogenesis.

PI_NAMEs: QIAN, ZHIJIAN  (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Binding;Binding Sites;Biological Process;Cells;Complex;crosslinking and immunoprecipitation sequencing;Data;demethylation;Dependence;Development;DNA Sequence Rearrangement;Ensure;epitranscriptome;Essential Genes;Gene Expression;Gene Expression Regulation;Gene Mutation;Genes;Genetic Models;Genomic approach;genomic data;Growth;Hematologic Neoplasms;Hematopoiesis;Hematopoietic stem cells;Human;improved;in vivo;knock-down;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;leukemogenesis;Machine Learning;Maintenance;Maps;Mediating;member;Messenger RNA;Methylation;Modification;Molecular;mouse genetics;mouse model;Mus;novel;novel therapeutic intervention;Oncogenes;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Play;Polyribosomes;Post-Transcriptional Regulation;posttranscriptional;Protein Binding Domain;Proteomics;Reader;recruit;Regulation;Ribosomes;RNA;RNA Binding;RNA methylation;RNA-Binding Proteins;Role;self-renewal;Site;stem;stem cell self renewal;success;TACC3 gene;targeted treatment;Testing;Transcript;transcriptome;transcriptome sequencing

PROJECT_TITLE: The Novel Role and Mechanism of RBM33 in Leukemogenesis

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Patient Safety;Stroke

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Swelling within the first week of large ischemic stroke can exert life-threatening pressure (known as mass effect) on vital brain structures essential to survival and good functional outcome. Accurate prediction of this phenomenon is essential to timely interventions and better outcomes. My research aims to improve prediction of life-threatening mass effect by developing dynamically updating risk prediction models using baseline and longitudinal variables.

PI_NAMEs: ONG, CHARLENE J (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Acute Brain Injuries;Admission activity;Affect;Arousal;Biometry;Boston;Brain;Brain Edema;Brain Stem;Calibration;career;career development;Caring;cerebrovascular;Clinical;clinical decision support;clinical decision-making;Clinical Investigator;Clinical Pathways;clinical practice;Clinical Research;Clinical Trials Design;cohort;Critical Illness;Data;Data Set;Decision Making;Deterioration;Development;disability;Discrimination;Epidemiologist;experience;functional outcomes;Funding;Future;Goals;Hour;Image;improved;improved outcome;Injury;innovation;Intervention;Investigation;Ischemia;Ischemic Stroke;Laboratories;Life;Medical;Medical center;Medical Records;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Middle Cerebral Artery Infarction;Middle Cerebral Artery Occlusion;Mission;Modeling;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multimodality;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurologist;novel;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;Pathway interactions;patient oriented;Patients;Performance;Pharmaceutical Preparations;pressure;prospective;Public Health Schools;Pupil;radiological imaging;recruit;Research;Research Design;Research Personnel;Risk;Risk Factors;risk prediction;risk prediction model;Scientist;serial imaging;Severities;skill acquisition;Specialist;Stroke;stroke patient;Structure;support tools;Surgical Decompression;Swelling;Testing;Time;tool;Training;Universities;Update

PROJECT_TITLE: Dynamic Risk Prediction of Life-Threatening Mass Effect After Ischemic Stroke

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

ORG_STATE: OR

PHR: Project Narrative Low-income women of childbearing age are at disproportionately high risk for depressive syndromes and, despite the availability of efficacious interventions, often do not receive the treatment they need. The proposed study seeks to expand the reach of an effective, Internet- based maternal depression intervention to low-income mothers by expanding implementation into the Head Start environment. This expansion has the potential to reduce maternal depression, improve related deficits in parenting behavior, and promote healthy child outcomes.

PI_NAMEs: BAGGETT, KATHLEEN M;FEIL, EDWARD GUSTAV (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Accountability;Address;Adoption;Awareness;Behavior;Behavioral;behavioral outcome;Belief;burden of illness;Characteristics;Child;Child Rearing;Cognitive;Cognitive Therapy;Communities;community setting;coping;cost;Depressed mood;Depressive disorder;depressive symptoms;design;disability;Disease remission;Distress;early childhood;economic disparity;Economics;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness study;effectiveness trial;effectiveness/implementation design;efficacious intervention;Emotional;Environment;Evaluation;evidence base;Exploration, Preparation, Implementation, and Sustainment;Female of child bearing age;Funding Agency;Head Start Program;Health Services Accessibility;health training;high risk;Hybrids;implementation evaluation;implementation outcomes;implementation process;implementation strategy;implementation study;improved;Internet;Intervention;Investigation;Investigational Therapies;Leadership;Learning;Low income;maternal depression;Mediating;Mediator;Mental Depression;Mental Health;Modeling;Moods;Mothers;Online Systems;Outcome;Outcome Assessment;Patient Self-Report;Phase;Poverty;practice setting;Preparation;Preventive;primary outcome;Process;Public Health;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Risk;secondary outcome;Service setting;Services;skills;Social support;symptomatology;therapeutic evaluation;Training;treatment as usual;treatment response;Waiting Lists;web-based intervention;Wit;Woman

PROJECT_TITLE: ICBT for Maternal Depression: Community Implementation in Head Start


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The engineering of tumor-specific bacteria is a transformative approach to cancer therapy, since bacteria can be genetically programmed to sense and respond to environments and locally release therapeutics. This proposal seeks to understand and engineer immunotherapeutic probiotic bacteria in the context of triple-negative breast cancer. The objective is to create a targeted therapy that locally delivers checkpoint inhibitors and cytokines to primary tumors and associated metastases, and stimulates systemic antitumor immunity with minimal side effects.

PI_NAMEs: ARPAIA, NICHOLAS ;DANINO, TAL  (contact)

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: 4T1;Adjuvant;Anaerobic Bacteria;Antibiotics;Antibodies;Antigen Presentation;antigen-specific T cells;Antitumor Response;Automobile Driving;Bacteria;Bar Codes;Biodistribution;Bone Tissue;Breast Cancer cell line;Breast Cancer Model;cancer immunotherapy;cancer infiltrating T cells;cancer therapy;CD47 gene;Cells;Cessation of life;chemotherapy;Circulation;Clinical Trials;Combined Modality Therapy;complement system;CTLA4 gene;cytokine;Cytolysis;Cytotoxic T-Lymphocytes;Defect;delivery vehicle;density;design;Disease;Distant Metastasis;Dose;efficacy evaluation;Engineered Probiotics;Engineering;Environment;Escherichia coli;Face;Future;Genetic;Genetic Transcription;Goals;Growth;Homing;host-microbe interactions;Immune checkpoint inhibitor;Immune system;immune-related adverse events;Immunity;immunogenicity;Immunologics;Immunotherapeutic agent;Immunotherapy;improved;In complete remission;in vivo imaging system;Inflammatory;Injections;innovation;Interleukin-12;Intravenous;intravenous administration;Kinetics;Knock-out;knockout gene;Lesion;Libraries;Lipopolysaccharides;Local Therapy;Luciferases;Lymphoma;Malignant Breast Neoplasm;Malignant Neoplasms;Measurement;Mediating;Medicine;Metastatic breast cancer;Metastatic Neoplasm to the Liver;microbial;Modeling;Molecular;Monitor;mortality;mouse model;Mus;mutant;nanobodies;neoantigens;Neoplasm Metastasis;Neutrophil Infiltration;novel;Oral;Oral Administration;Organ;Pathway interactions;Patient-Focused Outcomes;Patients;Peptides;Phagocytes;pre-clinical;preclinical development;prevent;Primary Lesion;Primary Neoplasm;probiotic therapy;Probiotics;Production;programmed cell death ligand 1;programs;Property;Reporting;safety assessment;side effect;Soft tissue sarcoma;Solid Neoplasm;Source;Specificity;Stains;Streptococcus;success;synergism;synthetic biology;systemic toxicity;T cell response;T-Lymphocyte;targeted treatment;Therapeutic;Toxic effect;transcription factor;Translations;triple-negative invasive breast carcinoma;Tropism;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Unresectable;Woman;Work

PROJECT_TITLE: Modulation of the tumor microenvironment with probiotic therapies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Neurosciences;Radiation Oncology

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Measurement of tissue pH and protein/metabolite concentrations using chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has been demonstrated to provide crucial insight into many disease pathologies, including tumors as well as to enable the early assessment of disease response to therapies. However, clinical translation of such CEST-MRI methods has been hindered by the qualitative nature of the image contrast, long image acquisition times, and the complex data processing required. This project proposes to develop, optimize, and translate to the clinic a novel Magnetic Resonance Fingerprinting method that allows for rapid and quantitative pH and protein/metabolite imaging and evaluate its potential for predicting response to stereotactic radiosurgery and differentiating progression versus treatment-related changes.

PI_NAMEs: COHEN, OURI  (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: 3-Dimensional;Address;Amides;Artificial Intelligence;Biological;Brain;Brain imaging;Brain Neoplasms;cancer imaging;Cancer Patient;Chemicals;chemotherapy;Clinic;Clinical;clinical translation;complex data;computerized data processing;contrast imaging;Custom;Data;Death Rate;deep learning;Development;Diagnosis;diagnostic tool;Dictionary;Dimensions;Discrimination;Disease;Disease Marker;Disease Progression;Early Diagnosis;experimental study;extracellular;Fingerprint;Goals;Guidelines;Head;Human;human subject;Image;imaging biomarker;Imaging Device;imaging modality;imaging study;Immunotherapy;improved;in vivo;Incidence;insight;macromolecule;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Glioma;Malignant Neoplasms;Maps;Measurement;Measures;Metastatic malignant neoplasm to brain;Methods;Motion;Nature;neural network;Neurologic Symptoms;Normal tissue morphology;novel;Operative Surgical Procedures;Outcome;Pathology;Patients;Physics;Physiologic pulse;Physiological;pre-clinical;predicting response;Primary Neoplasm;Property;Proteins;Protons;quantitative imaging;Radiation necrosis;Radiation therapy;radio frequency;Radiosurgery;reconstruction;Relaxation;Reproducibility;Resolution;Role;Scanning;Schedule;Signal Transduction;Slice;soft tissue;Solid;Specificity;Survival Rate;Techniques;Testing;Time;tissue mapping;Tissues;tool;Translating;treatment planning;Treatment Protocols;treatment response;tumor;tumor progression;Water

PROJECT_TITLE: Development of a Clinical CEST MR Fingerprinting Method for Treatment Response Assessment in Brain Metastases

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Alzheimer’s disease or dementia is one of the fastest growing cognitive disorders and is expected to affect nearly 14 million Americans by 2060. The disorder is preceded by a high-risk state known as mild cognitive impairment (MCI), which represents a viable target for interventions to prevent or slow down conversion to a full disease state. We are proposing to test the utility of a novel, computer-based brain training program to improve working memory in individuals with amnestic mild cognitive impairment, which, if successful could have significant personal, societal, and economic impact.

PI_NAMEs: SINGH, FIZA  (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Accounting;Activities of Daily Living;Adult;Affect;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;American;amnestic mild cognitive impairment;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;Animal Model;Animals;Anxiety;apolipoprotein E-4;Area;Attention;Attention deficit hyperactivity disorder;Back;Binding;Biological Markers;Brain;brain based;Brain region;Butyric Acids;Centers for Disease Control and Prevention (U.S.);Characteristics;Child;Clinical;Cognition;Cognition Disorders;Cognitive deficits;cognitive load;cognitive reserve;comparison control;Computers;cost;Dementia;Disease;Disease Progression;Dose;Down's Syndrome;Early identification;economic impact;Effect Modifiers (Epidemiology);efficacy testing;Electroencephalography;Eye;Frequencies;Functional impairment;Genetic;Genetic Risk;high risk;hippocampal pyramidal neuron;Histopathology;Impaired cognition;Impairment;improved;indexing;Individual;Interneurons;Intervention;Mediating;Mediator;Memory;Memory impairment;Mental Depression;Metaphor;mild cognitive impairment;multisensory;Neocortex;neural;neural circuit;neural network;Neurobiology;Neurodegenerative Disorders;neurofeedback;neuromechanism;neuron loss;Neurons;Neuropsychological Tests;neuroregulation;novel;older adult;Participant;Patients;Phase;Photic Stimulation;Placebos;Play;Population;post intervention;Prediction of Response to Therapy;Prefrontal Cortex;prevent;primary outcome;Public Health;Randomized;Reading;recruit;Reporting;Research;Research Personnel;response;Risk;Risk Factors;risk variant;Role;secondary outcome;Senile Plaques;Short-Term Memory;Synaptic plasticity;tau Proteins;tau-1;Techniques;Testing;therapy development;Training Programs;treatment response;Visual

PROJECT_TITLE: Enhancing gamma band response to improve working memory in individuals with mild cognitive impairment


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Lung;Lung Cancer;Precision Medicine

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The effectiveness of lung cancer targeted therapies is limited by the development of acquired drug resistance which eventually renders the treatments ineffective. This project seeks to identify the biological mechanisms that drive early tumor evolution in lung cancer patients treated with EGFR and ALK targeted therapies and determine if altering these processes may prevent or delay the subsequent development of drug resistance.

PI_NAMEs: HATA, AARON N (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: acquired drug resistance;Automobile Driving;Biochemical;biochemical tools;Biological;cancer cell;Cancer Patient;cancer type;Cell Survival;Cells;Characteristics;Clinical;clinically relevant;computerized tools;Computing Methodologies;Cytidine;Cytidine Deaminase;Data;Deamination;Development;Disease Progression;DNA;DNA Sequence Alteration;Drug resistance;drug resistance development;Drug Tolerance;Effectiveness;Elements;Enzymes;Epidermal Growth Factor Receptor;Evolution;Exhibits;Experimental Models;Foundations;Future;Gatekeeping;Genes;Genetic Transcription;Genomic Instability;Genomics;Germ Cells;Goals;Immune;Immune signaling;improved;ineffective therapies;Innate Immune Response;insight;kinase inhibitor;Link;Lung;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Modeling;Molecular;Mutagenesis;mutant;Mutation;neoplastic cell;next generation;non-genomic;Non-Small-Cell Lung Carcinoma;novel;Oncogenes;Oncogenic;Patients;Pharmacotherapy;Phosphotransferases;Play;Pre-Clinical Model;preempt;Prevalence;prevent;Process;Residual Neoplasm;Residual state;Resistance;Resistance development;resistance mechanism;response;RNA;RNA Editing;Role;ROS1 gene;Sampling;Signal Pathway;Signal Transduction;Specimen;targeted cancer therapy;targeted treatment;therapeutic development;treatment strategy;tumor;tumor heterogeneity;Virus;Work

PROJECT_TITLE: Mechanisms driving lung cancer evolution during targeted kinase inhibitor treatment

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Nutrition;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE Ketogenic diets are being investigated in the treatment of Alzheimer’s disease, but their mechanism of action is unknown. Given that spread of the tangle-forming protein tau among nerve cells is a key pathological event in Alzheimer’s disease, this project aims to understand how the ketone body β-hydroxybutyrate reduces tau spread in the brain. Successful execution of the proposed research will provide the mechanistic basis for prevention and treatment of Alzheimer’s disease and related dementia through improved ketone-based therapies.

PI_NAMEs: CHEN, XU  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease therapy;animal old age;Autophagocytosis;behavioral phenotyping;beta-Hydroxybutyrate;Bioenergetics;Biological Process;Brain;brain cell;Carbohydrates;Cell Culture System;cell type;Cells;Cellular biology;Chronic;Clinical Trials;cognitive function;Coupled;CRISPR interference;Data;Development;Diet;Disease;Disease Progression;effective intervention;enantiomer;Energy-Generating Resources;Enzymes;Epilepsy;Event;Fatty acid glycerol esters;fly;Frontotemporal Dementia;Future;Genetic;Glucose;Goals;human induced pluripotent stem cells;Impaired cognition;improved;In Vitro;in vivo;in vivo Model;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;innovation;Interneurons;Intervention;juvenile animal;ketogenic diet;Ketone Bodies;Ketones;Knock-out;Knowledge;Label;Link;Mass Spectrum Analysis;Mediating;Memory;Metabolic Pathway;metabolic phenotype;Metabolism;Modeling;Molecular;Motor Neurons;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurodegenerative phenotype;Neurofibrillary Tangles;Neurons;neuropathology;novel;oxidation;Pathogenesis;Pathologic;Pathway interactions;pharmacologic;Pharmacology;Phase I Clinical Trials;pre-clinical;preclinical study;prevent;Prevention;Production;protective effect;protein protein interaction;Proteins;proteostasis;Publications;recruit;Reducing diet;Regulation;Reporting;Repression;Research;response;Role;side effect;Signal Transduction;Signaling Molecule;single nucleus RNA-sequencing;Systems Biology;targeted treatment;tau interaction;tau Proteins;Tauopathies;Testing;Therapeutic;Tissue Banks;tool;trafficking;transcriptome;Transgenic Mice;Treatment Efficacy;treatment strategy;Vesicle

PROJECT_TITLE: Mechanisms by which the ketone body β-hydroxybutyrate counteracts tau pathogenesis


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

PHR: Project Narrative While KRAS has long been considered an “undruggable” target, novel covalent inhibitors selective for KRASG12C have entered the clinic, offering the unprecedented opportunity to target KRAS directly. However, early clinical data suggest that adaptive feedback and acquired resistance are major limitations of clinical benefit, especially in CRC patients. Here, we propose to define the key mechanisms of resistance to KRAS inhibition in CRC and devise therapeutic strategies to overcome resistance leveraging a unique collection of patient-derived models.

PI_NAMEs: CORCORAN, RYAN BRUCE (contact);KOPETZ, SCOTT

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Antibodies;Automobile Driving;Biological Assay;Biopsy;BRAF gene;Cancer Model;candidate identification;Clinic;Clinical;Clinical Data;Clinical Trials;clinically relevant;Collaborations;Collection;colon cancer patients;Colorectal Cancer;Combined Modality Therapy;Complex;Data;Development;efficacy evaluation;Epidermal Growth Factor Receptor;Evolution;FDA approved;Feedback;Genomics;Goals;Grant;Heterogeneity;Immunofluorescence Immunologic;improved;in vitro Model;in vivo;in vivo evaluation;in vivo Model;inhibitor;KRAS2 gene;KRASG12D;Lead;Malignant neoplasm of lung;Malignant Neoplasms;MAP Kinase Gene;Maps;Mediating;Mediator;Melanoma;Methods;Modeling;mutant;Mutate;Mutation;novel;novel therapeutic intervention;Organoids;Outcome;Pathway interactions;Patients;Pharmacodynamics;pre-clinical;Proteomics;PTPN11 gene;Resistance;resistance mechanism;response;Role;Signal Transduction;single cell analysis;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic;Time;tool;transcriptomics;Translations;tumor;tumor progression;University of Texas M D Anderson Cancer Center;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Overcoming adaptive feedback resistance to KRAS inhibition in colorectal cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Human Genome;Immunotherapy;Lymphatic Research;Lymphoma;Pediatric;Pediatric Cancer;Physical Activity;Rare Diseases

ORG_CITY: TUCSON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Immune cell therapy with chimeric antigen receptor (CAR) T cells has been shown to cure some patients with leukemia and lymphoma, but the broad application of this therapy has been limited due to the need to engineer T-cells collected from the patient who will receive the therapy. We propose to test the efficacy of an alternative type of T-cell that is mobilized to the blood with exercise and can be safely given to a wider range of patients, potentially serving as an “off the Shelf” CAR T-cell product. We expect to identify how these cells are mobilized with exercise and ascertain the biological pathways that make them better equipped to kill cancer cells so that they can be utilized in a future clinical trial to treat patients with leukemia and lymphoma.

PI_NAMEs: KATSANIS, EMMANUEL ;SIMPSON, RICHARD J (contact)

PROGRAM_OFFICER_NAME: XI, DAN

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adjuvant;Adrenergic Agonists;Adrenergic Antagonists;Adrenergic Receptor;Agonist;Allogenic;antagonist;Antigen Targeting;antigen test;Antitumor Response;arm;Biological;bisphosphonate;Blood;cancer cell;Cancer Patient;CAR T cell therapy;CD19 Antigens;CD19 gene;Cells;Cellular immunotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;Collecting Cell;Cross-Over Trials;Cyclic AMP;Cyclic AMP Receptors;cytokine release syndrome;cytotoxic;cytotoxicity;Development;Diagnosis;early phase clinical trial;efficacy testing;engineered T cells;Exercise;Exhibits;experience;Flow Cytometry;Future;Gene Expression Profile;Genes;Genetic Transcription;Goals;graft vs host disease;Growth;head-to-head comparison;Hematologic Neoplasms;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Homing;Human;Immunologic Adjuvants;improved;In complete remission;In Vitro;in vivo;Inferior;Infusion procedures;Interleukin-15;Interleukin-2;Isoproterenol;K-562;K562 Cells;Knock-in;leukemia;leukemia relapse;leukemia/lymphoma;Ligands;Lymphocyte;manufacture;Membrane Proteins;metabolic fitness;Methods;migration;Modeling;mouse model;Mus;Nadolol;Non-Hodgkin's Lymphoma;novel;Oxidative Phosphorylation;Pathway interactions;Patients;peripheral blood;Persons;Phenotype;Placebo Control;Population Heterogeneity;pre-clinical;preclinical study;programs;Proliferating;protein expression;Randomized;receptor;Receptor Activation;Recurrent disease;Refractory Disease;Relapse;response;Rest;Signal Pathway;Signal Transduction;single-cell RNA sequencing;T cell therapy;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;TNFSF10 gene;transcriptome;transcriptomics;Treatment Side Effects;tumor;Tumor Immunity;Up-Regulation;Variant;Vision;Zoledronate;γδ T cells

PROJECT_TITLE: Exercise as an Immune Adjuvant for Gamma Delta T-cell Therapies in Hematologic Malignancies

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: A fundamental question in immunology lies in understanding how the immune system can mount robust protective responses to foreign pathogens, while restricting collateral damage to endogenous tissues. Here, we will define the role of Foxp3-expressing regulatory T cells in coordinating this process, and elucidate the mechanisms by which Treg cells are able to suppress the activation of conventional T cells reactive to the same antigenic complex. In all, our work is expected to providing key insight into how the immune system prevents autoimmunity during pathogen infection, which has direct implications for the understanding of autoimmune disorders and inflammatory syndromes.

PI_NAMEs: SAVAGE, PETER AIDAN (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Antigens;Autoimmune Diseases;Autoimmunity;Bacteria;CD4 Positive T Lymphocytes;Cell Lineage;Cells;Clonal Deletion;Collaborations;Compensation;Complex;Compulsive Hoarding;confocal imaging;cytokine;Data;Discrimination;experimental study;FOXP3 gene;Gene Targeting;Genetic;Host Defense;Image;Imaging Techniques;immune activation;Immune system;Immunology;Immunosuppression;in vivo;Infection;Inflammatory;insight;Life;Ligands;Listeria monocytogenes;Magnetism;male;Mediating;MHC Class II Genes;Modality;Modeling;Mus;pathogen;Peptide/MHC Complex;Peptides;Peripheral;Physiological;Population;Positioning Attribute;prevent;Prevention;Process;Production;Productivity;Property;Prostate;Prostatic;prostatitis;Proteins;Recombinants;Regulatory T-Lymphocyte;Research;response;Role;Specificity;Syndrome;System;T cell infiltration;T cell response;T-Lymphocyte;Testing;Thymus Gland;Tissues;tool;Training;Transgenic Organisms;Wild Type Mouse;Work

PROJECT_TITLE: Specificity of regulatory T cell suppression during infection

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Hematology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE:  Haploidentical transplantation, where donors are matched at half of the HLA loci is a lifesaving alternative for patients without a suitable donor, and who can only be cured by a hematopoietic stem cell transplantation. Despite significant improvements, this curative treatment is still limited by increased rejection, often requiring high-dose immunosuppression to sustain donor grafts. This proposal seeks to illuminate the mechanisms by which the innate immune system recognizes haploidentical cells as foreign, with the ultimate goal to generate novel therapies that will enhance the efficiency of allogeneic transplantation.

PI_NAMEs: PINHO, SANDRA  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: adaptive immune response;Allogenic;Allografting;Automobile Driving;Biological Assay;Bone Marrow;Bone Marrow Transplantation;Cell Adhesion Molecules;cell type;Cells;Clinical;curative treatments;Cytometry;Data;Defect;Disease;donor stem cell;Dose;Eating;Endothelial Cells;Engineering;Engraftment;Failure;Flow Cytometry;Genetic Engineering;Genetic Transcription;Goals;Graft Rejection;Haplotypes;Hematopoietic;Hematopoietic Neoplasms;hematopoietic stem cell niche;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Histocompatibility;HLA Antigens;Homing;Homologous Transplantation;Human;Immune;Immune Evasion;Immune response;Immune Tolerance;Immunologics;Immunoprecipitation;immunoregulation;Immunosuppression;improved;improved outcome;In Vitro;in vivo;in vivo engraftment;innate immune checkpoint;innate immune function;Innate Immune Response;Innate Immune System;innovation;insight;Integrin alpha4beta1;Life;Major Histocompatibility Complex;Malignant - descriptor;Mediating;Molecular;Molecular Target;mouse model;Mus;Myelogenous;Myeloid Cells;Non-Malignant;novel;novel therapeutics;overexpression;Pathway interactions;Patients;Phagocytes;Phagocytosis;prevent;receptor;Recovery;response;Role;Series;Signal Pathway;Signal Transduction;stem cell engraftment;Stem cell transplant;Stromal Cells;success;Testing;transcriptome sequencing;transplant model;Transplantation;Vascular Cell Adhesion Molecule-1

PROJECT_TITLE: Mechanisms of hematopoietic stem cell engraftment

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Machine Learning and Artificial Intelligence;Mental Health;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Violence Research

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Experiencing child maltreatment is associated with poor physical, mental, social, and economic outcomes, which are often exacerbated by young people’s difficulties in sharing their experiences and accessing appropriate, supportive resources. This project will build the evidence base for interventions that reach maltreated young people through their preferred approaches, support them through their help-seeking efforts, and connect them with appropriate resources. Ultimately, this work may help young people develop resilience and avoid the harmful short- and long-term consequences of child maltreatment.

PI_NAMEs: SCHWAB-REESE, LAURA M (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Address;Adolescent;adolescent health;Adult;Area;Bioethics;career;Child;Child Abuse and Neglect;Child Health;child protective service;Childhood Injury;Code;Collaborations;Communication;Communication Methods;Data;Data Analytics;data visualization;developmental psychology;digital health;Disclosure;economic outcome;Evaluation;Evidence based intervention;Exhibits;experience;Foundations;Funding;Future;Goals;Hand;Health;health communication;help-seeking behavior;Interdisciplinary Study;intergenerational;Intervention;Knowledge;Language;large datasets;Law Enforcement;Linguistics;Machine Learning;maltreatment;meetings;Mentorship;Methods;National Institute of Child Health and Human Development;Natural Language Processing;novel strategies;Outcome;peer;Persons;phrases;pilot test;Population;Positioning Attribute;preference;prevent;Prevention strategy;Process;promote resilience;Psyche structure;Reporting;Research;Research Activity;Research Ethics;Research Personnel;Resources;response;Signs and Symptoms;skills;social;social media;Social outcome;Strategic Planning;successful intervention;supervised learning;System;Technology;technology intervention;Text;Text Messaging;Training;Training Activity;Trauma;treatment strategy;trend;United States;United States National Institutes of Health;unsupervised learning;video chat;Violence;violence perpetration;Vulnerable Populations;Work;Youth

PROJECT_TITLE: Meeting young people where they are: Using technology to promote resilience among child maltreatment victims

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Mental Health;Organ Transplantation;Patient Safety;Social Determinants of Health;Transplantation

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Inactivity (currently ineligible for transplant) on the kidney transplant (KT) waitlist occurs in 44% of those awaiting KT, disproportionally affecting older adults and incurring greater risk of death and poor KT surgical complications in addition to the high symptom burden (pain, disability and depressive symptoms) already experienced by this population. The purpose of this study is to adapt and pilot test the patient-directed in the home, team-based (nurse, occupational therapist, handy worker) Community Aging in Place- Advancing Better Living for Elders (CAPABLE) intervention to decrease barriers like symptom burden and low health literacy and patient activation in order to lessen time inactive on the KT waitlist. The novel adaptation of CAPABLE to this highly vulnerable population may result in more equitable KT allocation and better patient outcomes while potentially saving money, all of which will be further explored in the resulting R01 application.

PI_NAMEs: HLADEK, MELISSA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Admission activity;Affect;Age;aging in place;American;Behavior Therapy;Caring;Cohort Studies;Communities;control trial;depressive symptoms;design;Development;Dialysis procedure;disability;Disparity;Education;efficacy trial;Elderly;Elements;End stage renal failure;Enrollment;Environment;Equity;evidence base;Evidence based intervention;experience;Fatigue;feasibility testing;functional improvement;functional independence;Funding;Future;Goals;health literacy;Healthcare;Heterogeneity;Home;Home environment;Hospitalization;human centered design;improved;Individual;Internet;Intervention;Interview;Kidney Transplantation;Letters;low health literacy;Low income;member;Mental Depression;Mentors;Mentorship;Modeling;mortality;mortality risk;multidisciplinary;novel;Nurses;Nursing Homes;Occupational Therapist;older adult;open label;Outcome;Pain;Participant;participant interview;patient portal;Patient-Focused Outcomes;Patients;personalized approach;Persons;Phase;Physical Function;pilot test;Population;primary outcome;Procedures;programs;prospective;prototype;psychosocial;Quality of life;Randomized;recruit;reduce symptoms;Reporting;Research;Risk;Self Efficacy;Self Management;Services;social culture;social engagement;Social isolation;Social Network;Social support;Stress;Surgical complication;Symptom Burden;Symptoms;Telemedicine;Time;Training;transplant centers;transplant model;Transplantation;Voting;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Addressing Inactive Kidney Transplant Waitlist Status through Adapting a Tailored Psycho-Social-Environmental Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Treatment effect heterogeneity exists among patients with different characteristics including demographic, ge- netic, and biomarker risk factors. The proposed optimal composite scores will increase our ability to measure outcomes in AD and can be applied directly to personalized AD treatments. The proposed adaptive designs will improve the ﬂexibility of trial designs which would provide greater efﬁciency in AD drug development.

PI_NAMEs: SHAN, GUOGEN  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Aducanumab;Affect;African American;African American population;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Apolipoproteins;Biological Markers;Biology;Characteristics;clinical investigation;Clinical Trials;Cognition;cognitive ability;cognitive function;Communities;Data;Dementia;design;Disease Progression;Dose;drug development;effective therapy;Enrollment;Exposure to;Family;flexibility;follow-up;Futility;Genes;Genetic;Heterogeneity;Impaired cognition;improved;Individual;innovation;insight;Length;Longitudinal Studies;Measures;Memory;men;Methods;Minority Groups;Modification;neuroimaging;novel;open source;Outcome;Outcome Measure;Participant;Patients;Performance;Pharmaceutical Preparations;phase 3 study;Phase Ib Trial;prevent;primary outcome;Probability;Publishing;Race;rate of change;Research;Research Design;Rest;Risk Factors;Sample Size;sex;simulation;success;tau Proteins;Testing;Time;tool;treatment effect;Treatment Effectiveness;treatment response;trial design;United States Food and Drug Administration;verbal;Visit;Visuospatial;Woman

PROJECT_TITLE: Alzheimer's Disease: New Trial Designs for Emerging Challenges


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Digestive Diseases;Genetics;Liver Disease;Neurosciences;Nutrition;Prevention;Sleep Research

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Disruption and dysfunction of the circadian and metabolic systems, each increasingly prevalent in the modern world, are commonly associated despite an incomplete understanding of the mechanisms by which the two systems interact. Because the manipulation of the circadian system is notably tractable and safe as a target for disease prevention and intervention, this proposal aims to better characterize the ways in which the circadian and metabolic systems influence one another, how light exposure and feeding activity affect their temporal relationship, and how their relative timing is established. The increased understanding of the circadian- metabolic relationship will improve the ability of clinicians to intervene in the development of metabolic disorders using safe and effective changes to light exposure and diet.

PI_NAMEs: TACKENBERG, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Affect;Applied Skills;Bioinformatics;Biological;Brain;career development;circadian;circadian biology;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Collaborations;Core Facility;Coupling;Cues;Darkness;Data;data acquisition;Development;Diet;Disease;disorder prevention;Doctor of Philosophy;Eating;Environment;Etiology;experience;experimental study;Exposure to;feeding;Fellowship;Functional disorder;functional genomics;Gene Expression Regulation;Genes;glucose metabolism;Health;Hour;Image;improved;in vivo;Individual;Intervention;Knock-out;Knowledge;Laboratories;Length;Light;Link;lipid metabolism;Liver;Maintenance;Mammals;Measures;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic rate;Metabolism;Modernization;mouse model;Mus;obesogenic;Pacemakers;Pennsylvania;Periodicity;Peripheral;Phase;photoperiodicity;Physiological;Physiological Processes;Physiology;Postdoctoral Fellow;Preparation;Prevalence;prevent;Prevention;Production;Regulator Genes;Reporter;Reporter Genes;Research;Research Personnel;Research Project Grants;response;Running;Safety;skills;stem;suprachiasmatic nucleus;System;Technical Expertise;Techniques;Testing;therapeutic target;Time;tissue culture;Tissues;Training;Transcription Repressor;Transcriptional Regulation;transcriptome sequencing;Universities;Work

PROJECT_TITLE: Investigating the metabolic effects and de novo establishment of circadian timing differences between brain and liver


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Lung;Natural Products;Nutrition;Pulmonary Fibrosis;Rare Diseases

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE More effective treatments for idiopathic pulmonary fibrosis are urgently needed. In this phase I study, we will assess the safety of a green tea extract, epigallocatechin-3-gallate (EGCG) in combination with nintedanib or pirfenidone, as a novel antifibrotic agent in patients with idiopathic pulmonary fibrosis.

PI_NAMEs: CHAPMAN, HAROLD A;MARTINEZ, FERNANDO J (contact);SPINO, CATHERINE A

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acute;antifibrotic treatment;Attenuated;Binding;Biological Markers;Biology;Biopsy;Blood;Chemistry;Clinical;clinical research site;Clinical Trials;Clinical Trials Design;cohort;Collagen;Collagen Type I;Consumption;crosslink;Data;Deposition;design;Development;Diagnostic;Disease;Dose;Double-Blind Method;drug development;effective therapy;efficacy evaluation;empowerment;Enrollment;Ensure;Epigallocatechin Gallate;Epithelium;Exhibits;Family;FDA approved;Fibrillar Collagen;Fibroblasts;Fibrosis;follow-up;Future;Goals;Green tea;Health;Hepatic;Hepatotoxicity;high throughput screening;Human;idiopathic pulmonary fibrosis;Image;In Vitro;in vivo;indium-bleomycin;Inflammation;inhibitor;injured;innovation;insight;Interstitial Collagenase;Interstitial Lung Diseases;intervention cost;Laboratories;Link;LOX gene;LOXL2 gene;Lung;Measures;meter;Modeling;Molecular Probes;Monitor;Mus;nanomolar;National Heart, Lung, and Blood Institute;nintedanib;novel;Operative Surgical Procedures;Oral;Pathway interactions;patient subsets;Patients;periostin;Pharmaceutical Preparations;Phase;phase 1 study;phase 2 study;phase I trial;Phase II Clinical Trials;phase II trial;Phosphotransferases;Physiological;Pilot Projects;Pirfenidone;Placebo Control;Placebos;Plants;Population;Positron-Emission Tomography;pre-clinical;preclinical study;Principal Investigator;Progressive Disease;Proliferating;Pulmonary Fibrosis;Randomized;Renal function;Reporting;response;Role;Safety;safety assessment;Serum;Signal Transduction;small molecule;Specific qualifier value;Structure of parenchyma of lung;Surrogate Markers;Testing;therapeutic target;Tissues;Toxic effect;Transforming Growth Factor beta;treatment duration

PROJECT_TITLE: Phase 1 study of oral epigallocatechin-3-gallate (EGCG) in IPF patients


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: MADISON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Parents, pediatricians, and clinicians are concerned when children begin to talk late, a condition that affects 15% to 20% of children. Yet, little is known about bilingual late-talkers, their ability to learn information in both languages, and persistence vs. resolution of their language delay. This project examines how Spanish-English bilingual toddlers with typical language, bilingual late-talker, and bilingual children with Developmental Language Disorder (DLD) learn novel words in English and Spanish and what conditions can best facilitate their learning, with a particular interest in identifying risk and protective factors in bilingual late-talkers’ language outcomes.

PI_NAMEs: KAUSHANSKAYA, MARGARITA  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 2 year old;4 year old;Affect;Age;bilingualism;Child;Child Language;Cues;Development;Education;experimental study;Exposure to;Goals;Hour;improved;Individual;insight;interest;Intervention;Knowledge;Language;Language Delays;Language Development Disorders;language impairment;language outcome;Learning;Learning Disorders;Link;Literature;Maps;novel;Outcome;Parents;Participant;Pattern;pediatrician;peer;Predictive Factor;protective factors;Recording of previous events;Recovery;recruit;Resolution;Risk;Risk Factors;Role;Sampling;Series;Shapes;skills;Spanish;Spanish/English;spelling;statistical learning;stem;Structure;Suggestion;Testing;theories;Time;Toddler;United States;Vocabulary;word learning;Work

PROJECT_TITLE: Talking Late in Two Languages

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: The overall goal of the Brown Respiratory Research Training Program is to develop MD and PhD scientists whose research will improve understanding of the causes of respiratory diseases and improve the treatment and outcomes of these disorders. The program includes both pre-doctoral and post-doctoral training, including coursework, career development training, and mentored research.

PI_NAMEs: HARRINGTON, ELIZABETH O (contact);ROUNDS, SHARON IRENE SMITH;VENTETUOLO, COREY E;ZHOU, YANG

PROGRAM_OFFICER_NAME: KALANTARI, ROYA


NIH_SPENDING_CATS: Autoimmune Disease;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PUBLIC HEALTH RELEVANCE This project will determine effects of IBD-associated genetic variants on gene regulatory activity, gene expression, and tissue function. Uncovering these mechanisms will reveal how genetics contributes to IBD providing new avenues for therapeutic interventions and diagnosis.

PI_NAMEs: FUREY, TERRENCE S.;SHEIKH, SHEHZAD Z. (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Achievement;Affect;Alleles;Automobile Driving;Binding;Biological Assay;Brain;causal variant;Cell Differentiation process;Cell Physiology;cell type;Cells;Cellular biology;Chromatin;chronic inflammatory disease;Circulation;Cleavage Under Targets and Release Using Nuclease;Collaborations;Colon;Complement;Crohn's disease;Data;data resource;Dependovirus;Diagnosis;Digestive System Disorders;Disease;disease phenotype;disease prognosis;Environment;Epithelial Cells;Funding;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene expression variation;Genes;Genetic;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;genomic locus;genomic variation;Genotype;genotyped patients;Goals;Heart;Heterogeneity;high throughput analysis;Human;human DNA;human genomics;ileum;Inflammatory;Inflammatory Bowel Diseases;Intestinal Diseases;intestinal epithelium;Intestines;jun Oncogene;Libraries;Link;Liver;Lung;Measures;mesenteric lymph node;monolayer;Mus;Muscle;NF-kappa B;Organ;Pathogenesis;Patients;Permeability;Phenotype;Physiology;programs;Proliferating;Protocols documentation;public health relevance;Quantitative Trait Loci;Regulation;Regulatory Element;Reporter;Research Personnel;Role;sex;Site;System;Testing;Therapeutic Intervention;time use;Tissue Sample;Tissues;transcription factor;Transcriptional Regulation;Ulcerative Colitis;Untranslated RNA;Validation;Variant;variant of interest;vector

PROJECT_TITLE: High throughput functional studies of IBD-associated GWAS variants


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Inappropriate blood coagulation during serious infection leads to the formation of blood clots that contribute to, pulmonary embolism and heart attack, leading to human suffering and death. This proposal seeks to understand how certain viral and bacterial infections converge on a pathway of programmed cell death called pyroptosis that leads to activation of blood clotting. Our data identify an enzyme in lipid metabolism central to this process that may be a new drug target to prevent inappropriate clotting during infection.

PI_NAMEs: ANSARI, SHABBIR AHMED (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: 2019-nCoV;4 hydroxynonenal;Acute myocardial infarction;Adult;Affect;Aldehydes;Apoptosis;Arachidonate 15-Lipoxygenase;Atherosclerosis;Attenuated;Bacteremia;Bacterial Infections;Blood coagulation;CASP1 gene;Caspase;Cell Death;Cell surface;Cessation of life;chemical genetics;Coagulation Process;Data;Disease;Disseminated Intravascular Coagulation;Disulfiram;Enzymes;Epithelium;Escherichia coli;Evaluation;extracellular vesicles;FDA approved;Functional disorder;Gene Modified;Generations;Genes;genetic approach;Host Defense;Human;human disease;improved;In Vitro;in vivo;Infection;Inflammasome;Inflammatory;Ischemic Stroke;Life;lipid metabolism;Lipid Peroxidation;LOX gene;Lung infections;Macrophage;Mediating;Modeling;monocyte;mouse model;Multiple Organ Failure;Mus;Myocardial Infarction;new therapeutic target;Organ;pathogen;Pathogenicity;Pathologic;Pathway interactions;peroxidation;Phase;Phosphatidylserines;Play;Polyunsaturated Fatty Acids;Positioning Attribute;prevent;Process;Proteins;Pulmonary Embolism;Reporting;Resistance;Role;SARS-CoV-2 infection;Sepsis;septic;Testing;Therapeutically Targetable;Thromboplastin;Thrombosis;thrombotic;Training;United States;vesicular release;Virus Diseases;Work

PROJECT_TITLE: Lipid peroxidation- and pyroptosis-induced tissue factor activation in pathogen-induced blood coagulation

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(OA)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Despite their potential to advance the research agenda regarding American Indian/Alaska Native health disparities, Tribal Epidemiology Centers have fallen short of this promise due to limited scientific capacity. The Center will mobilize a wealth of resources to enable them to contribute significantly to such research.

PI_NAMEs: MANSON, SPERO MARTIN (contact);OCONNELL, JOAN M

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Advocate;Alaska Native;Alaska Native population;American Indian Population;American Indians;Applications Grants;Authorization documentation;career development;Chairperson;Colorado;Committee Members;Companions;Congresses;Data;data acquisition;Data Analytics;Data Collection;Data Science;data visualization;design;Disease Surveillance;disorder control;disorder prevention;Epidemiology;expectation;experience;Expert Testimony;Extramural Activities;Funding;Funding Opportunities;Future;Grant;Health;Health Care Reform;health disparity;Health Personnel;Health Priorities;Health Status;Healthcare;Hearing;Hour;Human Resources;improved;Individual;Inequity;Institution;interest;Knowledge;Leadership;learning materials;Mentors;minority health;minority health disparity;Mission;Monitor;National Institute on Minority Health and Health Disparities;Native American Research Center for Health;Native-Born;Nature;North Dakota;Persons;Policies;Poly(ADP-ribose) Polymerases;Positioning Attribute;Preparation;Program Development;programs;Public Health;Reporting;Research;Research Activity;Research Personnel;Resources;response;Risk;Role;Satellite Centers;Science;Scientist;Series;skills;success;Training;tribal leader;Tribes;United States Indian Health Service;United States National Institutes of Health;Vision;Voice;Writing

PROJECT_TITLE: Colorado Resource Center for Tribal Epidemiology Centers


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Follicular lymphoma comprises a substantial fraction new lymphoma diagnoses in the US and is essentially considered incurable at advanced stages. This project will develop an approach to target therapeutic drugs to lymph nodes, tissues where lymphoma tumors form and adaptive immune responses are regulated, in order to improve drug bioactivity and immunotherapeutic benefit while minimizing potential toxicities.

PI_NAMEs: FINN, M.G. ;THOMAS, SUSAN NAPIER (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Abscopal effect;adaptive immune response;Agammaglobulinaemia tyrosine kinase;Agonist;Animal Model;Animals;anti-CD20;Antigen-Presenting Cells;Apoptosis;B-Cell Lymphomas;B-Lymphocytes;biomaterial compatibility;Bolus Infusion;burden of illness;Cell Death Induction;Cells;Chemistry;chemotherapeutic agent;chemotherapy;clinical translation;Combination immunotherapy;controlled release;curative treatments;cytotoxic;Cytotoxic agent;cytotoxicity;design;Diagnosis;Disease;Dose;draining lymph node;Drug Delivery Systems;Drug Formulations;Drug Targeting;Engineering;Ensure;EZH2 gene;Fluorescence;Follicular Lymphoma;Formulation;Human;human disease;Immune;immune stimulatory agent;Immuno-Chemotherapy;Immunocompetent;immunogenic cell death;immunogenicity;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;in vivo;Indolent;Infusion procedures;innovation;insight;Ligands;Link;Lymph;lymph nodes;Lymphatic;Lymphocyte;Lymphoid Tissue;Lymphoma;Modeling;Monitor;Monoclonal Antibodies;mouse model;Mus;nanocarrier;nanoparticle;nanoparticle delivery;Nature;neoplastic cell;Non-Hodgkin's Lymphoma;Non-Malignant;novel therapeutic intervention;Outcome;particle;Penetration;Pharmaceutical Preparations;Phenotype;Population;Population Dynamics;pre-clinical;Pre-Clinical Model;programs;Radiation;radiation risk;Radiation therapy;Research;research clinical testing;Research Project Grants;Risk;Site;small molecule;Stimulator of Interferon Genes;synergism;System;Systemic Therapy;targeted treatment;Techniques;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;Tissues;TLR3 gene;Toxic effect;tumor;Tumor Burden;Tumor Immunity;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Lymph node-targeted multistage chemoimmunotherapy for lymphoma

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: KINGSTON

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: QUEEN'S UNIVERSITY AT KINGSTON

ORG_STATE: ON

ORG_ZIPCODE: K7L 3N6

PHR: Narrative As the Canadian Collaborating Clinical Trial Network, the Canadian Cancer Trials Group (CCTG) enhances NCTN's capacity to conduct innovative and potentially practice-changing trials. CCTG's scientific and regulatory expertise and national network of Canadian researchers contributes strategic and operational expertise, leverages Canadian infrastructure and resources to develop new trial proposals, increases the pool of potential trial participants for precision medicine, rare cancer and large definitive trials, and ensures efficient and effective oversight of NCTN trial conduct in Canada. The single most important benefit to public health realized is the improvement in the quantity and quality of survival of patients with cancer. By facilitating the conduct of trials that examine questions developed and driven by clinicians and that take advantage of emerging science and new cancer therapies, patients will have earlier access to new treatments, and results will be translated into practice, policy and improved cancer outcomes.

PI_NAMEs: DANCEY, JANET ELLEN (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Acceleration;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Big Data;Brain;Breast;Canada;Cancer Biology;Cancer Patient;cancer therapy;Cancer Therapy Evaluation Program;Cell Therapy;Child;Clinical;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Collection;Common Terminology Criteria for Adverse Events;Conduct Clinical Trials;cost;Data;Data Set;data sharing;Development;Diagnosis;digital health;Education;Ensure;Ethics;Evaluation;examination questions;experience;Goals;Head and Neck Cancer;Health;health economics;Hematology;Image;Immunooncology;improved;improved outcome;Information Technology;Infrastructure;innovation;insight;International;Intervention;Lead;Leadership;lifestyle intervention;Lung;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;meetings;method development;Methodology;Molecular;Monitor;Multi-Institutional Clinical Trial;National Clinical Trials Network;novel therapeutics;operation;Operative Surgical Procedures;organizational structure;Outcome;Participant;Patient Outcomes Assessments;Patients;Pharmacotherapy;Pilot Projects;Policies;Population;precision medicine;Precision Medicine Initiative;Process;programs;prospective;Public Health;rare cancer;Regulation;Research;research clinical testing;Research Personnel;Resources;Role;Science;Scientific Advances and Accomplishments;Site;Skin;statistics;Structure;Technology;technology development;Testing;tool;Training;Translating;Translational Research;Translations;urologic;wearable device

PROJECT_TITLE: Canadian Cancer Trials Group - Canadian Collaborating Clinical Trials Network


NIH_SPENDING_CATS: Cardiovascular;Genetics;Human Genome;Hypertension;Machine Learning and Artificial Intelligence

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Our overarching goal is to decipher the functional architecture of blood pressure (BP) regulation. We introduce an innovati9ve research program of using BP phenotype data in large cohorts with genome-cum-epigenome screens to quantify the contributions of each tissue and cell type to causal BP variation through their transcription factors (TFs), cognate cis regulatory elements (CREs) and target genes, organized into gene regulatory networks (GRNs). 1

PI_NAMEs: CHAKRAVARTI, ARAVINDA  (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Adrenal Glands;Affect;Aorta;Architecture;biobank;Biological Assay;Blood Pressure;blood pressure control;blood pressure regulation;Blood Vessels;cell type;Chromatin;Clinical;cohort;Collaborations;Common Core;Data;Defect;disease-causing mutation;Dissection;Endothelial Cells;endothelial dysfunction;Endothelium;Enhancers;epidemiology study;epigenome;exome;functional genomics;Gene Expression;Gene Expression Profile;gene function;gene regulatory network;Generations;Genes;Genetic Polymorphism;Genetic Research;Genome;genome wide association study;genome-wide;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;Heart;Heritability;Human;human tissue;Hypertension;in vitro Assay;Individual;inter-individual variation;International;Kidney;knock-down;Laboratories;Machine Learning;machine learning method;Maps;Methods;National Heart, Lung, and Blood Institute;Nitric Oxide;novel;Organ;Participant;phenotypic data;Physiological;pleiotropism;programs;Publishing;Pulse Pressure;Regulator Genes;Regulatory Element;Research;Risk;Risk Factors;Seminal;Small Interfering RNA;Testing;Tissues;trait;Trans-Omics for Precision Medicine;transcription factor;transcriptome sequencing;Umbilical vein;United States National Institutes of Health;Validation;Variant;vascular contributions;Vascular Smooth Muscle

PROJECT_TITLE: From GWAS loci to blood pressure genes, variants & mechanisms - Renewal


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Patient Safety;Rare Diseases

PROJECT_TERMS: Acceleration;Adolescent;Adolescent and Young Adult;Adult;Advisory Committees;Area;Big Data;Brain;Breast;Canada;Cancer Biology;cancer therapy;Cell Therapy;Child;clinical development;clinical research site;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Collection;Communication;Data;data management;Data Set;data sharing;Development;Diagnosis;digital health;Ensure;experience;Head and Neck Cancer;Hematology;Image;Immunooncology;improved;Information Technology;innovation;interest;International;Intervention;Leadership;lifestyle intervention;Lung;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;method development;Molecular;novel therapeutics;operation;Operative Surgical Procedures;organizational structure;Patients;Pharmacotherapy;Policies;Population;precision medicine;Process;programs;rare cancer;Regulation;Research;research clinical testing;Research Personnel;Research Project Grants;Resources;Role;Scientific Advances and Accomplishments;Site;Skin;statistics;Structure;Technology;technology development;Testing;Translational Research;Translations;urologic;working group


ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This is an application for a renewal from the Columbia University Irving Medical Center (CUIMC) for a post- doctoral training grant entitled the “Columbia Integrated Training Program in Infectious Disease Research” (Drs. Anne-Catrin Uhlemann and Magdalena Sobieszczyk, principal investigators). The goal of this proposal is to train postdoctoral fellows with MD or MD-PhD degrees in state-of-the-art infectious disease research technologies and information handling. This interdisciplinary program will provide trainees with the necessary skillset to become leaders in the field of Infectious Diseases and thereby be in position to meet the infectious disease threats of the future and protect the public health.

PI_NAMEs: SOBIESZCZYK, MAGDALENA ELZBIETA;UHLEMANN, ANNE-CATRIN  (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Infectious Diseases Research;Training Programs

PROJECT_TITLE: Columbia Integrated Training Program in Infectious Diseases Research

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Aging;Contraception/Reproduction;Genetics;Human Genome;Infertility;Maternal Health;Pregnancy;Women's Health Research

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE A prominent alteration in the uterine environment has recently been identified as a prevalent cause of age-related reproductive decline independent of blastocyst aneuploidy. This problem is likely due to a blunted progesterone (P4) responsiveness of the aging uterus, via its cognate nuclear receptor PGR. The goal of this proposal is to investigate the molecular mechanisms that underlie the age-associated uterine adaptability to pregnancy using physiological and genetic aging mouse models at single cell resolution.

PI_NAMEs: WANG, XIAOQIU  (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Ablation;Abnormal placentation;Acceleration;Address;advanced maternal age;Adverse effects;adverse pregnancy outcome;Age;age effect;age related;Age Years;aged;Aging;aging related;Aneuploidy;Attention;Binding;Biological Assay;Biological Process;Biology;Biology of Aging;blastocyst;candidate validation;Cell Proliferation;Cell Survival;Cells;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Collagen;Communication;comparative;conditional mutant;Congenital Abnormality;congenital heart abnormality;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data Set;Deacetylase;Decidual Cell Reactions;Defect;Deposition;Endometrial;Endometrial Stromal Cell;Endometrium;Environment;Epithelium;Estrogens;Female;Fertility;fetal;Fetal Growth Retardation;gene regulatory network;Genes;Genetic;Genetic Models;genetic signature;Genetic Transcription;Goals;Hormonal;Hormone Responsive;Human;Human Biology;human model;implantation;In Vitro;in vivo;Incidence;Infertility;Inflammation;insight;Invaded;knock-down;Knowledge;Litter Size;Mediating;migration;Modeling;Molecular;mouse model;multimodality;Mus;mutant mouse model;natural Blastocyst Implantation;Nature;new therapeutic target;novel;Nuclear Receptors;old mice;oocyte quality;Ovarian;Physiological;Physiology;Placentation;Population;Predisposition;Pregnancy;Pregnancy Maintenance;Pregnancy Outcome;premature;Premature Birth;Progesterone;Proliferating;Regulation;Regulatory Element;Reproduction;reproductive;reproductive senescence;Research;Resistance;Resolution;response;Risk;Risk Factors;Role;senescence;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;SIRT1 gene;Small Interfering RNA;Spontaneous abortion;Sterility;Stromal Cells;System;transcription regulatory network;transcriptome sequencing;Translating;uterine receptivity;Uterus;Wild Type Mouse;Woman;women's reproductive health;Work

PROJECT_TITLE: Deciphering molecular mechanisms controlling age-associated uterine adaptabilityto pregnancy

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


PROJECT_TERMS: Acceleration;Address;Adolescent;Adolescent and Young Adult;Adult;Advocacy;Awareness;Brain;Breast;Canada;Cancer Biology;cancer therapy;Cell Therapy;Child;clinical development;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Clinical Trials Unit;Collaborations;Collection;Communication;Communication Tools;Conduct Clinical Trials;Consent Forms;Continuing Education;Data Set;data sharing;Development;Diagnosis;digital health;Education;Ensure;Ethics;experience;Head and Neck Cancer;Health;Hematology;Human Resources;Image;improved;Information Technology;innovation;Institutional Review Boards;International;Intervention;Joints;Leadership;lifestyle intervention;Lung;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;member;method development;Molecular;Monitor;novel therapeutics;Operative Surgical Procedures;patient engagement;Patients;Pharmacotherapy;Policies;Population;precision medicine;Process;Protocols documentation;rare cancer;Recommendation;Regulation;Research;research clinical testing;Research Personnel;Role;Scientific Advances and Accomplishments;Site;Skin;Societies;Technology;technology development;Testing;tool;Translational Research;Translations;urologic;web portal;Work;working group

PROJECT_TITLE: Canadian Cancer Trials Group - Canadian Collaborating Clinical Trials Network: Clinical Trials Development & Member Site Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

PHR: The discovery of the first tau mutation (A152T) to influence risk for Alzheimer’s disease now provides a major opportunity to finally shed new light on the toxic role of tau in this disease. Our exciting data in a new animal model we have developed is already providing several clues, which all seem to be pointing towards an abnormal form of tau that is invisible by some classic markers of disease, yet a major driver of toxicity. The studies outlined in our proposal will further study how the A152T mutation changes tau to increase this abnormal form, which could identify new strategies to target this toxic species and stop disease progression.

PI_NAMEs: COOK, CASEY N (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: adenovirus mediated delivery;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Animal Model;Antibodies;Autopsy;Behavioral;Biochemical;Brain;brain tissue;cell type;Cells;Characteristics;corticobasal degeneration;Data;Dementia with Lewy Bodies;Deposition;Disease;disease classification;Disease Marker;disease phenotype;Disease Progression;disorder risk;Epitopes;Event;Gene Expression;Gene Expression Profile;Gene Transfer Techniques;Genes;Human;in vivo;Individual;insight;Link;Mass Spectrum Analysis;Mediating;Monitor;Mus;Mutation;Nerve Degeneration;neuropathology;novel;novel strategies;Pathogenicity;Pathologic;Patients;Pattern;Phenotype;Phosphorylation;Population;prevent;Progressive Supranuclear Palsy;Proline;promote resilience;Risk;Risk Factors;risk variant;Role;Sampling;Series;Serine;single nucleus RNA-sequencing;Site;Site-Directed Mutagenesis;Solubility;tau function;tau mutation;tau Proteins;tau-1;Tauopathies;Technology;Testing;Threonine;Toxic effect;Transcription Alteration;transcriptome;Variant

PROJECT_TITLE: Mechanistic insights into the link between the A152T risk variant and tauopathy

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]