ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Platelet interactions with fibrinogen, fibrin, and D-dimer (a fragment of fibrin), and/or von Willebrand factor contribute to abnormal clotting in heart attacks, stroke, and COVID-19. Past studies from this grant produced the drug abciximab, which is used to treat patients with heart attacks; tests to monitor the effects of antiplatelet drugs like clopidogrel (Plavix); and a new drug for heart attacks (RUC-4, zalunfiban) that is undergoing human testing. Our new studies are designed to develop a deeper understanding of the receptor that the platelet uses to bind to these proteins, αIIbβ3, using new sophisticated methods, with the goal of developing even better therapies for heart attacks, strokes, and COVID-19.

PI_NAMEs: COLLER, BARRY  (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: abciximab;Address;Affinity;Animals;antagonist;Antibodies;Antiplatelet Drugs;Area;Binding;Binding Sites;Biological Assay;Biology;Blood Platelets;Cells;Chimeric Proteins;clopidogrel;Clot retraction;Coagulation Process;Collaborations;Complement;Complex;Computer Simulation;computer studies;Computing Methodologies;COVID-19;crosslink;Cryoelectron Microscopy;Data;Data Set;design;Deuterium;Development;Disease;Docking;Drug Targeting;Electron Microscopy;Fab Immunoglobulins;Family;FDA approved;Fibrin;Fibrin fragment D;Fibrinogen;Fibrinolysis;Future;gamma Fibrinogen;Goals;Grant;Hemostatic function;high throughput screening;Hospitals;Human;Hydrogen;Impairment;Individual;Inflammation;inhibitor;Integrins;Leg;Length;Ligand Binding;Ligands;maltose-binding protein;Maps;Mass Spectrum Analysis;Medical;Methods;Molecular;Molecular Conformation;Monitor;Monoclonal Antibodies;monoclonal antibody production;mutant;Mutation;Mutation Analysis;Myocardial Infarction;nanodisk;Natural Immunity;Nature;Neoplasm Metastasis;novel;novel therapeutics;Pathologic;Pathology;Pathway interactions;Patients;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Platelet aggregation;Platelet Glycoprotein GPIIb-IIIa Complex;Plavix;Play;pre-clinical;Pre-Clinical Model;Preclinical Testing;Process;protein structure;Proteins;rational design;receptor;Receptor Activation;reconstitution;Resistance;Resolution;Review Literature;RGD (sequence);Role;small molecule;Solvents;Stroke;Structure;Testing;Therapeutic;thrombolysis;Thrombosis;Thrombus;Time;vascular injury;von Willebrand Factor;wound healing;X-Ray Crystallography

PROJECT_TITLE: Platelet Integrin AlphaIIbBeta3 Structure, Activation, and Ligand Binding: Fibrinogen, Fibrin, D-dimer, and von Willebrand Factor

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Biomedical research teams that combine diverse perspectives are predicted to generate more creative and innovative research projects for more effective problem solving. The long-term goal of UNC EDGE is to increase the diversity of scientists that enter and are retained in the genomics workforce using strategic recruitment, early exposure to career pathway education and research training, and multi-tiered mentoring. Ultimately, we expect this in-depth training in genomics at the University of North Carolina at Chapel Hill will give underrepresented professionals the opportunity to become stakeholders in the genomics-related research and healthcare decisions that affect their communities.

PI_NAMEs: BERG, JONATHAN S;IDERAABDULLAH, FOLAMI  (contact)

PROGRAM_OFFICER_NAME: HERNANDEZ-RAMON, ELENA ESTELA

PROJECT_TERMS: Academia;Address;Affect;African American population;Alaska Native;American;American Indians;Area;Awareness;Basic Science;Biomedical Research;Biotechnology;Black race;career;Career Choice;career development;Career Mobility;career networking;Communication;Communities;community college;Creativeness;Decision Making;Development;disadvantaged background;Disparity;Doctor of Philosophy;Education;education pathway;Educational Curriculum;Educational Models;Environment;Ethics;ethnic diversity;Ethnic Origin;experience;Exposure to;Faculty;faculty mentor;faculty research;Foundations;Genetic;genome sciences;Genomic medicine;Genomics;Goals;Government;graduate school;health care disparity;health disparity;Healthcare;higher education;Hispanic;Historically Black Colleges and Universities;Home;improved;Industry;innovation;interest;Interview;Knowledge;knowledgebase;Latinx;Learning;Legal;Medical;Medicine;meetings;mentoring community;Mentors;National Human Genome Research Institute;Native Hawaiian;North Carolina;Nurses;Occupations;Outcome;Pacific Islander;peer coaching;Persons;Population;precision medicine;Problem Solving;programs;recruit;Recruitment Activity;Research;Research Personnel;Research Project Grants;Research Training;Resources;rural area;Science;Scientist;Self Efficacy;skills;skills training;social;Societies;STEM career;STEM student;student training;Students;summer research;symposium;Talents;tool;Training;Training and Education;Training Programs;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved students;United States;Universities

PROJECT_TITLE: Educational Pathways to increase Diversity in Genomics (EDGE) at UNC Chapel Hill

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Both too little iron and too much iron lead to many serious diseases in humans including anemia, thalassemia, and hemochromatosis that together affect nearly 1 billion people worldwide. This proposal will investigate signaling proteins that control body iron balance and how genetic mutations found in patients with iron overload affect these proteins and their signaling function. Our ultimate goal is to understand how iron balance is controlled by the body, and to discover new ways to treat iron disorders.

PI_NAMEs: BABITT, JODIE L (contact);CHRISTIAN, JAN L

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adult;Affect;Alleles;Anemia;Anemia due to Chronic Disorder;Animal Model;Antibodies;beta Thalassemia;Biological Assay;Biological Process;Birth;BMP2 gene;BMP4;BMP5 gene;BMP6 gene;BMP7 gene;bone;Bone Morphogenetic Proteins;Chronic Kidney Failure;Clinical Trials;Data;Diet;dietary control;dimer;Dimerization;Disease;DNA Sequence Alteration;Embryonic Development;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Equilibrium;Erythropoiesis;Erythropoietin;Exhibits;Family member;Genetic;Genetic Transcription;Goals;Hemochromatosis;Hepatocyte;hepcidin;Hereditary Disease;Hereditary hemochromatosis;Heterozygote;Homeostasis;Hormones;Human;Impairment;improved;in vivo;Inflammation;insight;Iron;iron absorption;Iron Metabolism Disorders;Iron Overload;Knock-out;Knockout Mice;Lead;Ligands;Link;Liver;Mediator;member;metal transporting protein 1;mouse model;Mus;Mutation;novel;novel therapeutics;Nutrient;Organ;paracrine;Patients;Persons;pharmacologic;Phenotype;Phosphorylation;Play;Process;Production;Protein Precursors;Proteins;Publishing;receptor;Regulation;response;Role;Serum;Signal Pathway;Signal Transduction;Signaling Protein;System;Testing;Thalassemia;Therapeutic;Tissues;Toxic effect;Transforming Growth Factor beta;Wild Type Mouse;Work;Xenopus

PROJECT_TITLE: BMP Ligands in Hepcidin Regulation

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Pediatric

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PI_NAMEs: KIRSCHNER, LAWRENCE S (contact)

PROJECT_TERMS: Abbreviations;Academy;anti-cancer research;Applications Grants;Award;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer education;Cancer health equity;career development;Chemoprevention;college;Comprehensive Cancer Center;Development;Ecosystem;Education;education research;experience;Faculty;faculty mentor;Faculty Recruitment;Fellowship;Fellowship Program;Fostering;Funding;Future;Grant;high school;high school program;High School Student;Historically Black Colleges and Universities;improved;Laboratories;Leadership;Learning;leukemia;Malignant Neoplasms;Medical;Medicine;member;Mentors;Mentorship;Minority;Minority Women;Molecular Carcinogenesis;NCI Center for Cancer Research;Ohio;Oncology;Outcome;Paper;peer;physician-scientist training program;Population Sciences;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Process;programs;Recommendation;recruit;Research;Research Personnel;Research Priority;Research Support;Rotation;Science;Science, Technology, Engineering and Mathematics;Scientist;STEM program;Students;summer student;System;Systems Integration;Teacher Professional Development;Training;Training Activity;Training and Education;training opportunity;Training Programs;Training Support;translational therapeutics;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;University resources;Woman

PROJECT_TITLE: Cancer Research Training and Education Coordina

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Despite treatment advances, people with HIV (PWH) often still develop neurologic problems. The HIV Neurobehavioral Research Center will provide scientific leadership and technical support for innovative studies that address the neuropathogenesis, continued persistence, and treatment of neurocognitive impairment in PWH. A new area of emphasis will focus on identifying and characterizing complex neurobehavioral phenotypes (derived from aspects of mood and cognition) and how they relate to CNS mechanisms and HIV disease-related outcomes which will improve our understanding of these conditions in PWH as well as their assessment and treatment.

PI_NAMEs: ELLIS, RONALD J.;MOORE, DAVID J (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adverse outcome;Affect;affective disturbance;Anhedonia;anti-depressive agents;antiretroviral therapy;Anxiety;Area;base;Basic Science;Biological;Biological Availability;Biological Factors;Biological Markers;Biological Response Modifiers;Biology;Brain;Career Mobility;Central Nervous System;Central Nervous System Diseases;Classification;Clinical;Clinical Research;clinical risk;co-infection;Cognition;Cognition Disorders;Cognitive;comorbidity;Complex;Consequences of HIV;Data;Depressed mood;Depressive disorder;design;Development;Diagnosis;Diagnostic;Dimensions;Disease;Disease Progression;drug metabolism;Effectiveness;Epigenetic Process;Evaluation;Fright;Funding;Future;Goals;gut dysbiosis;gut microbiome;Healthcare;HIV;immune activation;Impaired cognition;improved;Individual;Inflammation;Infrastructure;innovation;International;Intervention;Investigation;Knowledge;Leadership;Link;Loneliness;Mental Depression;Mentors;Metabolic syndrome;Methods;microbial;microbiome;microbiome alteration;mitochondrial dysfunction;Mood Disorders;Moods;National Institute of Mental Health;neuroAIDS;neurobehavior;neurobehavioral;Neurobehavioral Manifestations;Neurocognitive Deficit;neuroinflammation;Neurologic;Neuropathogenesis;neuroprotection;neurotoxic;Neurovirology;neutralizing antibody;next generation;novel;Outcome;Participant;participant enrollment;Pathogenesis;Pathway interactions;Persons;Pharmaceutical Preparations;phenomenological models;Phenotype;Pilot Projects;Prevention;Prevention strategy;Psychiatry;Public Health;Quality of life;Registries;remote assessment;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;response;Risk Factors;Role;Scientist;Site;social engagement;Time;tool;training opportunity;trait;Translating;Translational Research;translational study;treatment strategy;United States National Institutes of Health;Viral

PROJECT_TITLE: HIV Neurobehavioral Research Center


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Mental Health;Neurosciences;Prevention

PI_NAMEs: MOORE, DAVID J (contact)

PROJECT_TERMS: Address;Advocate;assessment application;Charge;cohort;Collaborations;Communication;Communities;Consult;Data;data management;Decision Making;design;Ensure;Evaluation;federal policy;Feedback;Fostering;Future;Goals;Grant;HIV;Home;human subject;Information Dissemination;Information Systems;Institution;Institutional Policy;Institutional Review Boards;Interdisciplinary Study;interest;Leadership;lectures;Longitudinal cohort;Maintenance;Manuscripts;method development;Modality;Monitor;neuroAIDS;neurobehavioral;operation;Participant;participant retention;Policies;Preparation;Process;Provider;Recommendation;recruit;Registries;Reporting;Research;Research Personnel;Research Project Grants;Resource Allocation;Resources;Review Committee;Services;Statistical Methods;statistical service;statistics;Strategic Planning;Structure;student mentoring;Study Subject;United States National Institutes of Health;Universities;Videoconferencing;Vision;web site;working group

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE We are interested in understanding how complex brain circuits develop. We focus on the visual system, as its function is relatively well understood and it is especially important to human behavior. Our experiments have the potential to help develop techniques to restore visual function following eye trauma or disease, such as glaucoma, age related macular degeneration or amblyopia.

PI_NAMEs: CRAIR, MICHAEL C. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;age related changes;Age related macular degeneration;Amblyopia;Area;autism spectrum disorder;Axon;axon guidance;Behavior;Biological;Biological Models;Birth;Brain;Calcium;cell cortex;cell type;Cells;Central Nervous System;Characteristics;Child;cholinergic;Complex;Contrast Sensitivity;Cues;Custom;Development;Electrophysiology (science);Exhibits;experience;experimental study;extrastriate visual cortex;Eye;Eye diseases;Eye Injuries;Fragile X Syndrome;Gap Junctions;Genetic;Glaucoma;Glutamates;Growth;Human;Image;Imaging Techniques;In Vitro;in vivo;Inherited;interest;Intervention;Mammals;Maps;Mediating;Microscope;Midbrain structure;middle age;Molecular;monocular;Motion;Motor;Mus;neural circuit;Neuroanatomy;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neurons;Nose;novel;optical imaging;Pattern;Peripheral;Play;Process;Property;receptive field;recruit;response;Retina;Retinal Ganglion Cells;Role;segregation;self organization;Sensory;Shapes;spatial vision;spatiotemporal;starburst amacrine cell;Structure;superior colliculus Corpora quadrigemina;Techniques;Testing;Time;two-photon;V1 neuron;Viral;Vision;vision development;Visual;Visual Cortex;Visual impairment;visual map;Visual Pathways;visual receptive field;Visual System;Work

PROJECT_TITLE: Mechanisms and Role of Spontaneous Retinal Waves in Visual Development.

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE. Precision oncology has been demonstrably successful for the treatment of certain cancers. However, it has largely been limited to targeting mutant activated oncogenes while overlooking other pervasive mutations such as deletions of tumor suppressor genes. Our laboratory has pioneered an innovative therapeutic strategy, known as collateral lethality, which enables genomic deletions to serve as targets of precision medicine. Under this paradigm, we have developed an inhibitor of the glycolytic enzyme Enolase (ENO2 isoform) for the treatment of poorly prognosed tumors harboring homozygous deletions in ENO1. The goal of this proposal is to broaden the therapeutic reach of collateral lethality through strategic pro-drug modification of our laboratory’s core ENO2-preferred inhibitor so that ENO1-heterozygous deleted cancers, which comprise ~20% of all human cancers, may also be targeted.

PI_NAMEs: MILLWARD, STEVEN W (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 1p36;alkalinity;Anti-viral Agents;Antineoplastic Agents;Benzylamines;Bioenergetics;Biological;Cancer Patient;Cells;Central Nervous System;Charge;Chemicals;chemotherapy;Cholangiocarcinoma;clinical translation;Critiques;Data;design;Development;Dose;enolase;Ensure;Enzyme Inhibition;Enzymes;Evaluation;Event;Exhibits;Family;Fortification;Genes;genomic locus;Genomics;Glioblastoma;Glioma;Glycolysis;Goals;Heterozygote;Housekeeping;Human;Hydrolysis;improved;In Vitro;in vitro testing;inhibitor;innovation;insight;Investigational New Drug Application;Laboratories;Liver;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Metabolic;Metabolism;Methylation;MGMT gene;Modeling;Modification;molecular targeted therapies;mouse model;Mus;mutant;Mutation;nonhuman primate;Normal tissue morphology;novel;nucleotide analog;Oncogenes;patient population;Patients;Permeability;Pharmaceutical Preparations;pharmacologic;Pharmacologic Actions;pharmacophore;phosphonate;precision medicine;precision oncology;Primary carcinoma of the liver cells;Process;Prodrugs;promoter;Protein Isoforms;Safety;Sequence Deletion;small molecule;Specificity;Structure-Activity Relationship;subcutaneous;temozolomide;Testing;Therapeutic;thioester;Toxic effect;trait;tumor;tumor metabolism;tumor specificity;Tumor Subtype;Tumor Suppressor Genes;Work;Xenograft procedure

PROJECT_TITLE: Pro-Drug Enolase Inhibitors in Precision Oncology

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Lung;Lung Cancer;Prevention;Radiation Oncology;Rare Diseases

PI_NAMEs: RINGEL, MATTHEW D (contact)

PROJECT_TERMS: Abbreviations;Acute Myelocytic Leukemia;Adult;Area;Arts;assay development;Basic Science;BCL2 gene;Biological Models;Biological Specimen Banks;Biomedical Engineering;biomedical informatics;Biometry;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer initiation;cancer predisposition;cancer prevention;Catchment Area;Cellular biology;Chemoprevention;Chemotherapy and/or radiation;Childhood;Chronic Lymphocytic Leukemia;clinical translation;Clinical Treatment;Clinical Trials;Code;Collaborations;college;Colorectal;Comparative Pathology;Complex;Comprehensive Cancer Center;Computational Biology;Cryoelectron Microscopy;Cytotoxic Chemotherapy;design;Development;Diagnostic tests;digital imaging;DNA Damage;DNA Repair;Endometrial Carcinoma;Engineering;Epigenetic Process;epigenomics;Flow Cytometry;Funding;Future;Gene Expression Regulation;Gene Mutation;gene repair;Genes;Genetic Predisposition to Disease;Genetic study;genome wide association study;Genomics;Goals;Growth;Growth and Development function;Hereditary Nonpolyposis Colorectal Neoplasms;human tissue;Hypoxia;Immunooncology;improved;Incidence;innovation;Institution;Institutional Review Boards;inter-institutional;International;Intramural Research Program;kinase inhibitor;Knowledge;Knowledge acquisition;leukemia;leukemia tissue bank;leukemia treatment;Machine Learning;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;Manuscripts;Medicine;member;metabolomics;Microscopy;Mismatch Repair;Molecular Carcinogenesis;mortality;Mutate;Mutation;Natural Killer Cells;Neoplasm Metastasis;new technology;Non-Small-Cell Lung Carcinoma;novel;novel marker;novel therapeutics;Ohio;Oncology;Outcome;Participant;pathology imaging;Pathway interactions;Peer Review;Pharmaceutical Chemistry;Population Study;Productivity;programs;Proteomics;Public Health;Publications;Publishing;radiation response;Research;Research Personnel;Resistance;Resource Sharing;Resources;response;response biomarker;Role;Sampling;Science;screening guidelines;Services;Signal Transduction;Strategic Planning;T-Lymphocyte;targeted treatment;Therapeutic;Therapeutic Trials;therapy resistant;Tissue Engineering;transcriptomics;Translating;translational genomics;translational impact;Translational Research;translational scientist;translational therapeutics;Translations;Tumor Immunity;tumor immunology;tumor progression;United States National Institutes of Health;Universities;Untranslated RNA;validation studies;Vertebral column;Veterinary Medicine;Vision;Work

PROJECT_TITLE: Project 01: Cancer Biology (CB)


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: Project Narrative/Public Health Relevance Virtually all advances in medicine rely on the use of animal models to generate, test and evaluate hypotheses relevant to human biology. Chief among these animal models is the laboratory mouse. In this era of genome- scale, data-driven biomedical research, the Mouse Genome Database (MGD) plays a pivotal role in standardizing, integrating, and disseminating information about the laboratory mouse as a model system for understanding human biology and disease processes. MGD's focus on supporting three distinct user groups -- basic scientists, clinical researchers, and computational biologists -- ensures the broadest possible impact of the resource in contributing to the development of new tools and hypotheses for advancing our understanding of the human genome and how it functions, and for advancing genomic approaches to improving human health.

PI_NAMEs: BULT, CAROL J (contact)

PROGRAM_OFFICER_NAME: XIRASAGAR, SANDHYA

PROJECT_TERMS: Address;Adopted;Algorithmic Software;Alleles;Animal Model;Area;Automobile Driving;Basic Science;bioinformatics tool;Biological;Biological Models;Biological Process;Biology;Biomedical Research;Catalogs;Clinical;Clinical Research;Collaborations;Communication;Communities;Community Outreach;comparative genomics;Complex;Computational Biology;Computer software;cost;cost effective;Data;Data Analyses;Data Commons;data curation;data ecosystem;data integration;data modeling;data submission;Databases;Development;Development Plans;Disease;disease model;Documentation;Ecosystem;Educational workshop;Ensure;Evolution;Funding;gene product;Genes;Genetic;Genetic Variation;genome annotation;genome database;genome editing;genome resource;genome-wide;Genomic approach;Genomic medicine;Genomics;Genotype;Goals;Health;Human;Human Biology;human disease;Human Genetics;Human Genome;human model;improved;Industry;information model;Information Resources;Information Systems;Infrastructure;infrastructure development;innovation;International;Knowledge;knowledge commons;knowledgebase;Laboratory mice;Leadership;Maintenance;Medicine;meetings;Microtus;Mission;Modality;model organisms databases;Molecular;mouse genetics;mouse genome;Mus;Mutation;new technology;Nomenclature;Online Systems;Ontology;outreach;Phenotype;Play;Positioning Attribute;Process;Provider;public health relevance;Research;Research Personnel;Resources;Role;Scientist;Seasons;Secure;Security;Semantics;Services;social media;software development;Source;Standardization;System;Testing;tool;Training;translational scientist;Update;Variant;virtual;Work

PROJECT_TITLE: Mouse Genome Database (MGD): A Core Knowledge Resource for Functional Characterization of the Human Genome


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: NARRATIVE A hallmark of prostate cancer is enhanced androgen receptor (AR) activity. A mechanism by which AR mis- regulation is thought to occur is through acquisition of new binding sites throughout the genome that shift the transcriptional program from differentiation to proliferation. In this proposal, we investigate how mutations in ETS factors, clinically important oncogenic drivers of prostate cancer, promote luminal cell identity and regulate chromatin architecture of cancerous prostate tissues, including by co-option of AR function.

PI_NAMEs: SAWYERS, CHARLES L. (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Ablation;androgen deprivation therapy;Androgen Receptor;Androgens;Apoptosis;Architecture;ATAC-seq;Automobile Driving;Bacteria;Basal Cell;Binding Sites;Biochemical;Biological;Biological Assay;biophysical analysis;cancer genome;cancer initiation;Cancerous;Castration;Cell Death;Cell Line;Cells;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;Computer Analysis;Contracts;Coupled;CRISPR library;CRISPR screen;Dependence;deprivation;DNA;DNA Binding;Doxycycline;Electrophoretic Mobility Shift Assay;Enhancers;Enzymes;Epigenetic Process;Epithelial Cells;Epithelium;ETS Family Protein;ETV4 gene;experimental study;Funding;gain of function;Gene Expression;Gene Silencing;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genome;Goals;Growth Factor;Human;Impairment;in vivo;Investigation;Length;Ligands;loss of function;Malignant neoplasm of prostate;Measures;men;Modeling;Mus;Mutate;Mutation;novel;Oncogenic;Operative Surgical Procedures;Organoids;overexpression;paracrine;Patients;Phenotype;Play;progenitor;programs;Proliferating;Prostate;Prostatic Intraepithelial Neoplasias;protein protein interaction;protein purification;Proteins;Publishing;Radical Prostatectomy;Reagent;receptor;receptor binding;receptor expression;receptor function;Receptor Signaling;reconstitution;Relaxation;Reproducibility;Role;Sampling;screening;single cell analysis;single-cell RNA sequencing;Site;Specific qualifier value;System;Time;Tissues;tool;transcription factor;transcriptome;Transplantation;tumor

PROJECT_TITLE: Role of ETS factors in specifying prostate luminal cell identity and androgen receptor dependence

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: LETENDRE, SCOTT L (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;addiction;Aging;Applications Grants;Area;Award;career;Career Mobility;Central Nervous System;Clinical Psychology;Clinical Research;Cognition;cohort;Consultations;Data;Data Collection;Development;Education;education resources;Elements;Environment;experience;Extramural Activities;Feedback;Fellowship;Fostering;Funding;Goals;Grant;HIV;HIV/AIDS;Infrastructure;innovation;Interdisciplinary Study;Investments;Joints;K-Series Research Career Programs;Lead;Leadership;Link;Manuscripts;meetings;Mental Depression;Methods;microbiome;multidisciplinary;National Institute of Mental Health;neuroAIDS;neurobehavioral;Neurovirology;next generation;NIH Program Announcements;Participant;Pathogenesis;peer coaching;Peer Review;Performance;Phenotype;Preparation;programs;Publications;Request for Applications;Research;Research Design;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Support;Resources;Schools;Series;Specimen;Study Section;symposium;tool;Training;Training Programs;Translational Research;United States National Institutes of Health;Work

PROJECT_TITLE: Developmental Core


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: TAMPA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Glaucoma is an ocular disease that causes progressive and irreversible vision loss by damaging optic nerve fibers as they exit the eye. High eye pressure is a well-established risk factor for the disease, but it is not the only factor. This project uses one-of-a-kind technology that we have created for monitoring and controlling pressure in conscious animals to examine mechanisms and possible contribution of circadian fluctuations in eye pressure, eye pressure history, and brain pressure to glaucoma.

PI_NAMEs: PASSAGLIA, CHRISTOPHER L (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Agonist;Animals;antagonist;aqueous;Aqueous Humor;Autonomic nervous system;Axon;Blindness;Body Temperature;Brain;Cell Survival;Cessation of life;circadian;Circadian Rhythms;Clinical;clinical care;Conscious;Contrast Sensitivity;Darkness;Disease;Disease Progression;Dissection;Electroretinography;Exhibits;experience;Experimental Models;experimental study;Eye;Eye diseases;Frequencies;Functional disorder;Glaucoma;high intraocular pressure;Individual;Infusion procedures;insight;interest;Intracranial Hypertension;Intracranial Pressure;Light;Liquid substance;Measurement;Measures;mechanical energy;Mechanical Stress;Medicine;Monitor;Motor Activity;Nerve;Nerve Fibers;Neuromodulator;novel strategies;Onset of illness;Optic Disk;Optic Nerve;Patients;Periodicity;pharmacologic;Pharmacologic Substance;Phase;Physiologic Intraocular Pressure;Predisposition;pressure;Production;Property;Rattus;Recording of previous events;Regulation;Research;Research Personnel;response;Retinal Ganglion Cells;Risk Factors;Role;Severities;Signal Transduction;Stress;suprachiasmatic nucleus;System;targeted agent;Technology;Testing;Therapeutic Effect;Time;translaminar pressure gradient

PROJECT_TITLE: Continuous measurement and control of intraocular pressure in normal and glaucomatous eyes


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoarthritis

PHR: NARRATIVE  This project will develop a novel deep learning reconstruction technique for multi-component relaxometry. The proposed reconstruction technique can offer a unique opportunity to explore the acceleration of multi- component relaxation mapping by leveraging the latest deep learning techniques, resulting in an accurate, efficient, and reliable model that is widely generalizable to different relaxation types in many body regions. Successful completion of the project will provide a clinically applicable multi-component relaxometry technique that can help better study, understand and stage diseases such as osteoarthritis and multiple sclerosis from the tissue microstructural and biochemical level.

PI_NAMEs: LIU, FANG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: Acceleration;Address;Algorithms;Anatomy;Architecture;Behavior;Biochemical;Biological Markers;Body Regions;Cartilage;Characteristics;Clinical;clinical application;clinical translation;Computer Vision Systems;contrast imaging;convolutional neural network;Data;Data Set;deep learning;deep learning model;Degenerative polyarthritis;Demyelinations;digital;Disease;Ensure;Environment;Foundations;generative adversarial network;Goals;human tissue;Image;image reconstruction;Imaging Techniques;improved;Knee;Knee Osteoarthritis;Knowledge;Magnetic Resonance Imaging;Maps;Measures;Methods;Modeling;Multiple Sclerosis;Myelin;neural network;Noise;novel;Pathology;Patients;Performance;pre-clinical;Process;Property;prospective;Protons;rapid technique;reconstruction;Relaxation;Reproducibility;Research;Research Proposals;Resolution;Sampling;Scanning;Signal Transduction;simulation;Staging;Structure;synthetic data;System;Techniques;Time;tissue mapping;Tissues;Training;training data;Water

PROJECT_TITLE: Deep Learning Reconstruction for Rapid Multi-Component Relaxometry

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: VON AH, DIANE MARIE (contact)

PROJECT_TERMS: Abbreviations;Address;Appalachian Region;Area;Arts;Award;Behavior;behavior test;Behavior Therapy;Behavioral;Behavioral Medicine;Biological;Biology;Biometry;Breast;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer health equity;Cancer Patient;Cancer Survivor;Cancer Survivorship;Catchment Area;Centers for Population Health;Cervical;Chemoprevention;Clinic;clinical center;Clinical Sciences;cohort;Collaborations;college;Colorectal;colorectal cancer prevention;community engagement;community organizations;Community Outreach;Comprehensive Cancer Center;Dentistry;Development;Diet;Discipline of Nursing;Doctor of Philosophy;Early Diagnosis;Ecology;Education;Ensure;Epidemiology;Etiology;Evidence based practice;Faculty;Federally Qualified Health Center;Funding;Future;Genetic;genetic epidemiology;Genomics;Goals;Grant;Health;health disparity;Health Services;high risk behavior;HPV screening;Human;Human papilloma virus infection;Human Papilloma Virus Vaccination;Immigrant;Immunooncology;Immunotherapy;implementation science;implementation study;improved;Incidence;Institution;Intervention;Intervention Studies;Intervention Trial;K-Series Research Career Programs;large datasets;Laws;Lead;leukemia;life span;Lung;Malignant Neoplasms;Manuscripts;Medical;Medicine;member;Mentors;Minority;Minority Groups;Molecular;Molecular Carcinogenesis;Molecular Epidemiology;Morbidity - disease rate;mortality;multidisciplinary;next generation;Nutrient;Obesity;Observational Study;Ohio;Outcome;Outcomes Research;Participant;patient population;Patient-Focused Outcomes;Patients;Pediatric Hospitals;Peer Review;Physical activity;Phytochemical;Policies;Population;prevent;Productivity;programs;Public Health;Publications;Publishing;Quality of life;recruit;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Risk;Risk Behaviors;Risk Factors;Rural;Safety;Science;Services;Surveys;survivorship;System;Testing;Thinking;Tobacco;Tobacco use;Training;Translational Research;translational therapeutics;Treatment Efficacy;Underserved Population;United States National Institutes of Health;Universities;urban area;urban minority;Women's Health

PROJECT_TITLE: Project 02: Cancer Control (CC)


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Normal vision is hinged on the ability of photoreceptors to transmit their light excitation to downstream neurons in the visual circuit. Failure of this synaptic communication is a leading cause of congenital forms of night blindness. The work proposed herein will yield a clearer understanding of molecular mechanisms by which photoreceptors communicate with other retina neurons. This is expected to increase our understanding of blinding retina diseases and could offer new strategies for their amelioration.

PI_NAMEs: MARTEMYANOV, KIRILL A. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Animal Model;Biochemical;Biological;Biological Assay;Bipolar Neuron;Blindness;Cell Adhesion;Cell Adhesion Molecules;Cell Communication;Cells;Cellular Assay;Communication;comorbidity;Complex;Cone;Detection;Disease;Dystroglycan;Elements;Funding;Glutamates;Goals;GTP-Binding Proteins;Guanosine Triphosphate Phosphohydrolases;Human;Individual;infancy;Inherited;innovation;insight;Intervention;Lead;Light;Link;Membrane Potentials;Molecular;mouse model;Neurons;neurotransmitter release;Neurotransmitters;Night Blindness;novel;novel therapeutic intervention;Ochotonidae;Orphan;Photons;Photophobia;Photoreceptors;Phototransduction;Physiological;Play;postsynaptic;presynaptic;Presynaptic Terminals;programs;Property;protein activation;protein complex;Proteins;receptor;reconstitution;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal neuron;Rod;Role;scaffold;Sensory;Signal Transduction;Signaling Protein;Specific qualifier value;Stimulus;Synapses;synaptic failure;synaptic function;Synaptic Receptors;Synaptic Transmission;Testing;tool;transmission process;Vertebrate Photoreceptors;Vision;Visual;voltage;Work

PROJECT_TITLE: Molecular Organization of the First Visual Synapse


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Prevention

PI_NAMEs: KNIGHT, ROB  (contact)

PROJECT_TERMS: Address;Affect;AIDS clinical trial group;AIDS prevention;Anti-Retroviral Agents;Anxiety;Bacterial Genome;Bioinformatics;Biological;Biology;Brain;career development;Central Nervous System;Certification;Chemicals;Clinical Data;Clinical Trials;co-infection;Cognition;cognitive change;cohort;Collaborations;comorbidity;companion diagnostics;Complex;Consultations;Cytomegalovirus;Data;Data Analyses;data integration;data reuse;Databases;Deposition;depressive symptoms;Development;Diet;Dimensions;Disease;Disparity;dysbiosis;Educational workshop;Feces;Functional disorder;Funding;Future;gamma-Aminobutyric Acid;Genetic;Genotype;Goals;Grant;gut microbiome;Health;health disparity;HIV;HIV Infections;HIV Seronegativity;Human;Immune system;improved;Individual;individual response;Inflammation;insight;insulin sensitivity;International;Intervention;Investigation;Journals;Laboratories;Leadership;Link;Liquid Chromatography;Loneliness;low socioeconomic status;Mediating;Medical;meetings;men who have sex with men;Mental Depression;Mentors;Metabolic syndrome;metabolome;metabolomics;Metagenomics;Methods;microbiome;Mission;Mood Disorders;Moods;multidisciplinary;Negative Valence;Nervous System Disorder;neurobehavioral;Neurocognition;Neurocognitive Deficit;neurotoxic;Neurotransmitters;Neurovirology;Non-Insulin-Dependent Diabetes Mellitus;novel;open source;Outcome;Participant;perceived stress;Persons;Pharmaceutical Preparations;Phenotype;Pilot Projects;Plasma;Play;Positive Valence;Probiotics;Process;Production;Protocols documentation;Psychiatry;Research;Research Design;Research Personnel;resilience;Resources;Ribosomal RNA;Rodent Model;Role;Sampling;Science;Self Efficacy;Serotonin;Shotguns;Sleep disturbances;Spanish;stool sample;substance use;tandem mass spectrometry;Taxonomy;Techniques;Technology;Testing;therapy design;Time;Training;treatment response;Underserved Population;United States National Institutes of Health;Viral;Viral Genome;Virus Diseases;Work;Writing

PROJECT_TITLE: Microbiome Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative  This work will define the mechanism of dual artemisinin metabolite action in combating artemisinin resistance. Here, we explore the quantitative parasite killing contribution of heme-artemisinin adducts by a novel mechanism of the metabolite, novel irreversible heme crystal inhibition, and optimum combination killing with the quinolines.

PI_NAMEs: SULLIVAN, DAVID JOSEPH (contact);VEKILOV, PETER G

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: adduct;Anti-malarials;artemether;Artemisinins;artesunate;Atomic Force Microscopy;Biological;Biological Assay;Biological Markers;Cell Fractionation;Combined Modality Therapy;Crystal Formation;Crystallization;Data;Drug Combinations;drug isolation;Drug Metabolic Detoxication;Drug resistance;drug-sensitive;Electrons;Erythrocytes;Free Radicals;Goals;Growth;Hematin;Heme;Hemoglobin;hemozoin;Human;In Situ;In Vitro;in vivo;insight;Investigation;Knowledge;Lipids;Malaria;Measures;Molecular;mutant;novel;Parasite resistance;Parasites;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiologic pulse;Physiological;Plasmodium;Plasmodium falciparum;Prodrugs;Proteins;quinoline;Radiolabeled;Research;Resistance;response;Role;Structure;synergism;Testing;Time;time use;uptake;Work

PROJECT_TITLE: Dual artemisinin action combats resistance

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Inflammatory Bowel Disease

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative PD-1 inhibitors are increasingly used for the treatment of solid tumors yet their clinical utility is limited by the development of immune-related adverse events, of which colitis is the most common, severe side effect. The goal of this project is to use a combination of single cell genomic and T cell receptor sequencing in combination with multiplexed immunofluorescence microscopy and organoid culture to characterize the interactions between damaged colonic epithelium and cytotoxic T lymphocytes, which sustain tissue inflammation following PD-1 blockade. These findings are directly relevant to public health because they will increase our understanding of how PD-1 signaling promotes immune tolerance in the gut and will identify new strategies to diagnose, treat, and prevent PD-1 colitis and other gastrointestinal immune-mediated diseases.

PI_NAMEs: THOMAS, MOLLY  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: anti-PD-1;Antibodies;Apoptosis;Area;Autoimmunity;Award;B-Cell Antigen Receptor;biobank;Biological Assay;Blocking Antibodies;Blood;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;CEACAM7 gene;Cells;checkpoint therapy;Chemotaxis;Chromatin;Circulation;Clinical;cohort;Colitis;Colon;Colonic inflammation;Colonoscopy;Complex;CTLA4 blockade;CTLA4 gene;CXCL11 gene;CXCL13 gene;CXCR3 gene;cytokine;cytotoxic;Cytotoxic T-Lymphocytes;cytotoxicity;Data;Data Set;Defect;Development;Diagnosis;diagnostic development;diagnostic tool;Disease;Disseminated Malignant Neoplasm;Down-Regulation;effector T cell;Endothelial Cells;Epigenetic Process;Epithelial Cells;epithelial injury;Epithelium;exhaustion;experimental study;fighting;Gastroenterology;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Gene Expression Profile;General Hospitals;Genes;Genetic Transcription;Goals;Health;Heterogeneity;Home;Homeostasis;Homing;Human;IL17 gene;IL7R gene;Immune;Immune checkpoint inhibitor;Immune system;Immune Tolerance;immune-related adverse events;Immunity;Immunofluorescence Microscopy;Immunologic Receptors;Immunologics;Immunology;Immunooncology;immunoregulation;Immunotherapy;improved;In Situ;In Vitro;Individual;Inflammation;Inflammatory Bowel Diseases;innovation;instructor;Interferon Type II;Interferons;Interleukin-10;interleukin-22;Licensing;Ligands;Malignant Neoplasms;Maps;Massachusetts;Mediating;medical schools;Medicine;Memory;Mentors;Mesenchymal;Microscopy;Modeling;Mollies;Monoclonal Antibodies;Mucous Membrane;Mus;NR4A1 gene;Oncology;Organoids;Pathologic;Patients;PD-1 blockade;PD-1 inhibitors;peripheral blood;Phenotype;Physicians;Play;Population;Positioning Attribute;prevent;Program Development;programmed cell death ligand 1;programmed cell death protein 1;programs;prospective;Public Health;receptor;Reporting;Repression;Research;response;Role;Scientist;side effect;Signal Transduction;single cell ATAC-seq;single cell genomics;single-cell RNA sequencing;skills;Solid Neoplasm;System;T cell receptor repertoire sequencing;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;TCR Activation;Testing;Therapeutic;therapeutic target;tissue resident memory T cell;Tissues;Toxic effect;treatment strategy;Up-Regulation;water channel;Work

PROJECT_TITLE: Unraveling the Role of PD-1 in CD8+ Tissue-Resident Memory T Cell Homeostasis and Epithelial Damage in Human Colitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Mental Illness;Neurosciences;Prevention;Social Determinants of Health

PI_NAMEs: IUDICELLO, JENNIFER E (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;adverse childhood events;AIDS clinical trial group;AIDS prevention;Anhedonia;Anti-Retroviral Agents;Anxiety;Anxiety Disorders;Area;authority;Basic Science;Biological;Biological Factors;Biological Markers;career development;Certification;Clinical;Clinical assessments;Clinical Research;Clinical Trials;clinically relevant;co-infection;Cognition;Cognitive;Collaborations;comorbidity;Complex;Consult;Consultations;COVID-19 pandemic;Cytomegalovirus;daily functioning;Data;data standards;Depressed mood;depressive symptoms;Development;Diagnostic;Dimensions;Disease;Disparity;Doctor of Philosophy;Educational workshop;Evaluation;Extramural Activities;follow-up;Fright;Funding;Goals;gut-brain axis;Health;health disparity;HIV;HIV Seronegativity;immune depression;Impairment;Individual;Inflammatory;instrument;Interdisciplinary Study;Interleukin-6;International;Intervention;Investigation;Leadership;Life;Link;Loneliness;low socioeconomic status;Major Depressive Disorder;Maps;Medical;meetings;Mental Depression;Mental disorders;Mental Health;Mentors;Metabolic syndrome;metabolome;Methods;microbiome;Mood Disorders;Moods;multidisciplinary;neuroAIDS;neurobehavioral;Neurocognition;Neurocognitive;Neurocognitive Deficit;neuroinflammation;Neurologic;Neuropsychology;neurotoxic;Outcome;outreach;Participant;Pathogenesis;Persons;Phenotype;Pilot Projects;Process;Psychiatric Diagnosis;psychiatric symptom;Psychiatrist;Psychiatry;Psychological Factors;Psychosocial Factor;recruit;Registries;remote assessment;Reproducibility;Research;Research Design;Research Personnel;Research Priority;resilience;Resources;Risk;Role;Science;Self Efficacy;Services;social stigma;Social support;Spanish;Standardization;standardize measure;Stress;substance use;Symptoms;Telephone;Time;Training;Translational Research;translational study;Trauma;Underserved Population;Validation;Vinorelbine tartrate;Viral Load result;Visit;Work

PROJECT_TITLE: Neurobehavioral & Psychiatry Core


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

PHR: Narrative Borrelia burgdorferi (Bb) is the causative agent of Lyme disease that is transmitted through the bite of tix between small rodents and humans. This proposal is to determine how Bb can establish persistent infection in mice, and thereby act as a reservoir for infections of humans. We will test how antibodies generated during Bb infection might be reduced in their functionality, which could explain why the antibody responses to Bb that is strongly induced cannot clear the infection, and could identify potential future therapeutic targets for Lyme disease.

PI_NAMEs: BAUMGARTH, NICOLE  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: adaptive immune response;Address;Affect;Antibiotics;Antibodies;Antibody Affinity;Antibody Response;Antibody-mediated protection;Antigen Presentation;Antigen-Antibody Complex;Antigen-Presenting Cells;Antigens;Apoptosis;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-Lymphocytes;Bacteria;Bacterial Infections;Binding;Bite;Blood;Borrelia burgdorferi;Canis familiaris;CD4 Positive T Lymphocytes;Cell Communication;Cells;chronic infection;Clinical;Complement Receptor;Complex;Country;Data;design;Disease;effectiveness evaluation;emerging pathogen;Equus caballus;Excision;Failure;Follicular Dendritic Cells;Future;Human;Humoral Immunities;IgG Receptors;Immune;immune activation;Immune Evasion;Immune response;Immune system;Immune Targeting;Immunity;immunodeficiency;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Individual;Infection;Knowledge;Life Cycle Stages;Link;Lyme Disease;Maintenance;Measures;Mediating;Memory B-Lymphocyte;Modification;Mus;pathogen;Pathogenesis;Phagocytosis;plasma cell development;Plasma Cells;Plasmablast;Polysaccharides;Positioning Attribute;Process;receptor;receptor binding;Receptor Signaling;Recombinants;Regulation;response;Rodent;Role;Serum;Signal Transduction;Solid;Structure of germinal center of lymph node;Testing;Therapeutic Intervention;therapeutic target;tick transmission;Tissues;transmission process;Vector-transmitted infectious disease

PROJECT_TITLE: Antibody-mediated immunity to Borrelia burgdorferi

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases;Transplantation

PI_NAMEs: WOYACH, JENNIFER A. (contact)

PROJECT_TERMS: Abbreviations;Acute Myelocytic Leukemia;Address;Adult;adult T-cell leukemia cell;Adult T-Cell Leukemia/Lymphoma;Agammaglobulinaemia tyrosine kinase;animal imaging;Area;Biology;biomedical informatics;Biometry;Blood;Bone Marrow;Bone Marrow Transplantation;Cancer Biology;Cancer Burden;Cancer Center Support Grant;Cancer Control;Cancer Etiology;Cancer Hospital;cancer prevention;Cancer Survivorship;Caring;Catchment Area;Cell Therapy;Cessation of life;Chemoprevention;chemotherapy;Child;Childhood;chronic graft versus host disease;Chronic Lymphocytic Leukemia;Classification;Clinical;clinical application;clinical development;clinical practice;Clinical Treatment;Clinical Trials;Collaborations;college;Comparative Pathology;Complement;Comprehensive Cancer Center;curative treatments;Dedications;Development;digital imaging;Disease;Dissection;Elderly;Engineering;Enrollment;Epigenetic Process;Etiology;Fertilization;Flow Cytometry;Fostering;Foundations;Friends;Funding;Future;Genetic;Genomics;Goals;Grant;Hairy Cell Leukemia;Hematopoietic;Immuno-Chemotherapy;Immunooncology;Immunotherapeutic agent;Immunotherapy;improved;Infrastructure;Institution;Intervention;Intervention Trial;investigator-initiated trial;leukemia;leukemia tissue bank;leukemia treatment;leukemia/lymphoma;Leukemic Cell;leukemic transformation;life span;Malignant Neoplasms;Manuscripts;Medicine;member;Microscopy;Molecular Carcinogenesis;neoplastic cell;NK cell therapy;novel therapeutics;Ohio;Oncology;Participant;Pathogenesis;pathology imaging;Patients;Pediatric Hospitals;Pediatric Oncology;Peer Review;Pharmaceutical Chemistry;Pharmacy facility;Phase;pre-clinical;precision medicine;preclinical development;preclinical study;Prognosis;programs;Proteomics;Publications;Publishing;Recording of previous events;recruit;Research;research clinical testing;Research Personnel;Resource Sharing;risk stratification;Science;Services;Societies;success;synergism;targeted treatment;Therapeutic Agents;Therapeutic Trials;Training and Education;Translating;translational genomics;translational therapeutics;Translations;transplantation therapy;Tyrosine Kinase Inhibitor;United States National Institutes of Health;Universities;Untranslated RNA;Veterinary Medicine;Work

PROJECT_TITLE: Project 03: Leukemia Research (LR)


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Pediatric

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Anxiety disorders are highly prevalent during adolescence and associated with an increased severity of symptoms and comorbidities, yet predominant behavioral treatments have limited or no success for nearly half of the adolescent population. The proposed research will use a novel conditioned safety protocol to elucidate the mechanisms by which mice learn to utilize stimuli explicitly predicting safety (i.e., ‘safety signals’) to inhibit fear responding during adolescence. By investigating processes of fear inhibition specifically as they manifest during development, this research will inform the types and timing of behavioral treatments for adolescents that will maximize effectiveness.

PI_NAMEs: MEYER, HEIDI CATHERINE (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TITLE: Developmental Engagement of Neural Circuitry Underlying Safety Learning

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Mental Health;Mental Illness;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Prevention;Sleep Research

PI_NAMEs: ELLIS, RONALD J. (contact)

PROJECT_TERMS: Address;AIDS clinical trial group;AIDS prevention;Anhedonia;antibody test;antiretroviral therapy;Anxiety;Area;Behavioral;Biological Assay;Biological Markers;Biology;Blood;blood-brain barrier function;career development;Cell Aging;Central Nervous System;Cerebrospinal Fluid;Certification;Circadian Rhythms;Clinical;Clinical assessments;Clinical Trials;co-infection;Cognition;cohort;Collaborations;Collection;comorbidity;Complex;Consultations;cytokine;Cytomegalovirus;Cytomegalovirus Infections;Development;Diabetes Mellitus;Diagnosis;diet and exercise;dietary;Disease Outcome;Disparity;Educational workshop;Evaluation;Exercise;Extramural Activities;Feces;frailty;Funding;Goals;gut microbiome;Health;health literacy;Healthcare;high throughput technology;HIV;HIV Infections;Hypertension;Image;Impairment;Inflammation;Insulin Resistance;Interdisciplinary Study;interest;International;Intervention;intervention effect;Investigation;Laboratories;Leadership;Life Style;Loneliness;Magnetic Resonance Imaging;Measures;Medical;meetings;Mental Depression;Mental disorders;Mental Health;Mentors;Metabolic syndrome;Methods;microbial;microbiome;Minority Groups;Modernization;neuroAIDS;neurobehavioral;neurobehavioral disorder;Neurocognitive;Neurocognitive Deficit;neuroimaging;Neurologic;neuromechanism;neuroprotection;neurotoxicity;Neurotransmitters;Neurovirology;next generation;novel;Older Population;Outcome;Participant;Peripheral;Persons;pharmacologic;Phenotype;Physical Exercise;Population;Positron-Emission Tomography;probiotic supplementation;Process;Production;Protocols documentation;Psychiatry;Recording of previous events;remediation;repository;Research;research and development;Research Infrastructure;Research Personnel;resilience;resilience factor;Resources;Risk Factors;Scanning;Science;Self Efficacy;Serotonin;Services;Sleep;social;Social Functioning;Social support;specific biomarkers;Spinal Puncture;Standardization;Stress;Structure;T-Cell Activation;Techniques;therapy design;Time;Toxoplasmosis;Training;Treatment outcome

PROJECT_TITLE: NeuroMedical Core


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Rheumatoid Arthritis

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Despite several new treatment options, many patients with rheumatoid arthritis continue to suffer from poorly controlled disease. We will clarify which mechanism(s) of pathological protein citrullination occur in rheumatoid arthritis patients to enable the discovery of better and more targeted therapies that specifically address the molecular mechanisms that underpin the pathogenesis of this disease.

PI_NAMEs: MUSTELIN, TOMAS M (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: adaptive immunity;Address;Affect;Alleles;Anti-citrullinated peptide antibody;Antibodies;Applications Grants;Arginine;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;Biological;Biological Markers;Biology;Cells;citrullinated protein;cyclic citrullinated peptide;Data;Development;Disease;Drug Targeting;Enzymes;gain of function;Genetic;Head;Human;in vivo;Individual;Infection;inhibitor;insight;interest;Link;Malignant Neoplasms;Molecular;Monitor;NADPH Oxidase;Natural Immunity;neutrophil;novel;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Predisposition;Protein-arginine deiminase;Proteins;Publishing;Reaction;Regulation;Reporting;Research;Respiratory Burst;response;Rheumatoid Arthritis;Role;Sampling;Site;Sjogren's Syndrome;small molecule;Specificity;Surface;Sushi Domain;Synovial joint;systemic autoimmune disease;Systemic Lupus Erythematosus;targeted treatment;Testing;Therapeutic;Work

PROJECT_TITLE: Role of protein citrullination in rheumatoid arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because an integrated, co-designed system that is capable of rapidly identifying and responding to medical and social needs will promote better, more equitable patient- and population-level outcomes. While this application focuses on pediatrics, the concepts learned through this grant, will be readily applicable to other populations that are similarly affected by the social and environmental determinants of health and for other healthcare systems planning responses to both medical and social risks. The proposed research is in line with AHRQ’s special emphasis on the social determinants, priority on children, and stated mission as it will “produce evidence to make health care safer, higher quality, more accessible, eq- uitable, and affordable.”

PI_NAMEs: BECK, ANDREW FINKEL (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Achieving Pediatric Health Equity by Responding to Identified Sociomedical risks with Effective Unified Purpose –Co-design and Evaluation of the RISEUP System

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Genetics;HIV/AIDS;Infectious Diseases;Mental Health;Neurodegenerative;Neurosciences;Prevention

PI_NAMEs: GIANELLA WEIBEL, SARA  (contact)

PROJECT_TERMS: anti-depressive agents;antiretroviral therapy;Astrocytes;ATAC-seq;Autophagocytosis;Biogenesis;Biological Assay;Biological Markers;Biological Specimen Banks;Biology;biomarker identification;Blood;blood-brain barrier function;Body Fluids;Brain;brain tissue;Central Nervous System;ChIP-seq;Chromatin;Chronic;Clinical;clinically relevant;co-infection;Cognition Disorders;Cognitive;cohort;Collaborations;Consultations;cost effectiveness;Cytosine;Development;Disease Progression;Drug resistance;Drug Screening;Epigenetic Process;Exposure to;flexibility;Gatekeeping;Gene Chips;Gene Expression;Genotype;Goals;Haplotypes;histone modification;HIV;HIV Infections;Homeostasis;Human;Immunophilins;improved;In Situ;In Vitro;in vivo;Income;Inflammation;Inflammation Mediators;innovation;integration site;International;Investigation;Knowledge;Laboratories;Long-Term Survivors;Macrophage;Mental Depression;Metabolic;Methods;Methylation;microbiome;Microscopic;Mission;Mitochondria;mitochondrial dysfunction;Mood Disorders;Moods;Myeloid Cells;National NeuroAids Tissue Consortium;Nerve Degeneration;nerve injury;neuroAIDS;neurobehavioral;Neurobiology;Neurocognitive;Neurocognitive Deficit;neurocognitive disorder;Neuroglia;neuromechanism;Neurons;neuropathology;neurotoxic;Neurovirology;Pharmaceutical Preparations;Phenotype;Plasma;Population;Procedures;Process;Productivity;programs;Proviruses;Psychiatry;quality assurance;Quality Control;Regimen;Research;Research Personnel;Resources;response;RNA;Sampling;screening;Services;Signal Transduction;Strategic Planning;Structure;System;Techniques;Technology;Time;Tissues;Training;Tropism;Viral;virology

PROJECT_TITLE: NeuroVirology & Biology Core


NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Disability Research;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

PHR: Project Narrative Advances in neuroprosthetic devices could soon allow substitution of lost senses, such as sight in blind. However, even with the best sensory prostheses, neural signal generated will be innately different and much degraded from those of biological sensory organs such as the retina. Here we will examine whether the adult brain can undergo appropriate changes to utilize artificially generated neural signal originating from a visual prosthesis analog.

PI_NAMEs: LEE, HEY-KYOUNG  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Adult;analog;area striata;Auditory Perception;Behavior;behavior test;Behavioral Paradigm;Biological;blind;Blindness;Brain;Cochlear Implants;Coupled;Coupling;Data;deaf;Development;Devices;digital;discrimination task;Dorsal;Effectiveness;Electrodes;Engineering;Fiber Optics;Future;Head;Hearing;Image;Implant;implantable device;implantation;indexing;Individual;interest;Lateral Geniculate Body;learned behavior;Learning;lens;Life;Light;Location;Mus;neural;neural correlate;Neurons;neuroprosthesis;neurotransmission;novel;Ocular Dominance;Ocular Prosthesis;Optic Nerve;optical fiber;Optics;optogenetics;Organ;Outcome;Pattern;Preparation;Process;Prosthesis;Recovery;Research;Retina;Sensory;sensory cortex;sensory prosthesis;Signal Transduction;Source;Speech Perception;Structure;success;System;Testing;Thalamic structure;Tissues;tool;two-photon;V1 neuron;Variant;Vision;Visual;Visual Cortex;Work

PROJECT_TITLE: Optical thalamic prosthesis analog for investigating V1 plasticity in blind adult mice


PI_NAMEs: CLINTON, STEVEN K (contact)

PROJECT_TERMS: Abbreviations;Agriculture;animal imaging;anti-cancer;anti-cancer research;Area;Arts;Automobile Driving;Award;biochemical model;Biological;biomedical informatics;Biometry;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer risk;cancer survival;carcinogenesis;Carcinogenesis Inhibition;Catchment Area;Cell model;Chemicals;Chemoprevention;Chemopreventive Agent;Clinic;clinical investigation;Clinical Research;Clinical Treatment;Clinical Trials;Collaborations;college;Colorectal;colorectal cancer prevention;Comparative Pathology;Complement;Comprehensive Cancer Center;Dentistry;Development;Diet;Diet and Nutrition;Dietary Assessment;dietary guidelines;Dietary Intervention;Dietary Practices;digital imaging;Doctor of Philosophy;early phase clinical trial;Ecology;Education;Endogenous Factors;Endometrial;Engineering;Enrollment;Environment;Environmental Science;Exogenous Factors;Exposure to;Faculty;Flow Cytometry;Food;Foundations;Funding;Future;Genetic;Genetic Counseling;Genetic Predisposition to Disease;Genetic Screening;Genomics;Germ Lines;Goals;graduate student;Grant;high risk population;Hormonal;Human;Immune Targeting;Immunology;Immunooncology;Immunotherapeutic agent;In Vitro;in vivo;Incidence;innovation;Institution;Intervention Studies;Intervention Trial;Investments;K-Series Research Career Programs;laboratory experiment;Laboratory Study;Lesion;leukemia;Life Style;Malignant - descriptor;Malignant Neoplasms;Manuscripts;Mediating;Mediator;Medicine;member;Mentors;Metabolic;Metabolism;microbiome;microbiota;Microscopy;Molecular;Molecular Carcinogenesis;Morbidity - disease rate;mortality;multimodal learning;Natural Source;Neoplastic Cell Transformation;novel;Nutrient;nutrition;Nutritional;nutritional guideline;Ohio;Participant;pathology imaging;Peer Review;Pharmacognosy;Pharmacologic Substance;Pharmacy facility;Phase;Phytochemical;pre-clinical;Pre-Clinical Model;premalignant;Prevention;Prevention program;Prevention strategy;preventive intervention;Process;Program Sustainability;programs;Proteomics;Public Health;Public Policy;Publications;Publishing;recruit;Research;Research Personnel;Resource Sharing;Risk;Safety;Science;screening;Services;Structural Chemistry;System;Testing;Time;Tissue Engineering;Tobacco;Toxic effect;Training;Translational Research;translational therapeutics;Translations;Tumor Immunity;tumor progression;undergraduate student;United States National Institutes of Health;Universities;Veterinary Medicine

PROJECT_TITLE: Project 04: Molecular Carcinogenesis and Chemoprevention (MCC)


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Metabolism influences the epigenetic state of a cell because metabolic intermediates also act as the donor molecules for epigenetic marks such as histone methylation. Here, we will study how metabolic changes in the aging eye affect its epigenome, disrupting the rhythmic cycles of gene expression in the eye that synchronize expression of proteins with the day/night cycle. We propose that disrupting these rhythmic expression cycles in the eye enhances the risk of retinal degeneration, contributing to the increased risk of ocular disease with advanced age.

PI_NAMEs: WEAKE, VIKKI MARIE (contact)

PROJECT_TERMS: Adenosylhomocysteinase;Affect;Age;Age of Onset;age related;age related changes;Aging;Alternative Splicing;Amino Acids;ARNTL gene;Binding;Biological Models;Biological Rhythm;Caloric Restriction;Carbon;Cell Survival;cell type;Cells;Chromatin;circadian;Circadian Dysregulation;circadian pacemaker;circadian regulation;Circadian Rhythms;Cysteine;Data;Deposition;Development;Diabetic Retinopathy;DNA Methylation;Drosophila eye;Drosophila genus;Elderly;Embryo;Enzymes;Epigenetic Process;epigenome;Event;Exposure to;extend lifespan;Eye;Eye diseases;Feedback;Fibroblasts;fly;Folic Acid;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;genetic manipulation;Genetic Transcription;genome-wide;Glaucoma;Global Change;Health;Hepatocyte;histone methylation;histone methyltransferase;Histones;Human;in vitro activity;Intake;knock-down;Light;Link;Messenger RNA;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolism;Methionine;Methionine Metabolism Pathway;Methylation;Methyltransferase;Modeling;Mus;Myopia;neuroprotection;normal aging;Orthologous Gene;Output;Oxidative Stress;Pathway interactions;Periodicity;Phase;Photoreceptors;Phototransduction;Play;premature;prevent;programs;protein expression;Publishing;Reactive Oxygen Species;Retinal Cone;Retinal Degeneration;Risk;RNA Splicing;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Series;Structure;Study models;Testing;Time;transcription factor;transcriptome;transcriptome sequencing;Translations;Vertebrates;Visual;whole genome

PROJECT_TITLE: Chromatin connects metabolism to circadian gene regulation in the aging eye

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The scientific impact of an NMR experiment depends on the sample quality and biological relevance of the sample conditions, the quality of the NMR data, and the ability to interpret the NMR data. This proposal develops biological NMR technology across all three areas with the overarching goal of advancing NMR studies of biomedically important problems. By reducing the time, cost, effort and learning curve to acquire NMR data and improving the quality and reproducibility of data analysis, we will enable wider application and increase the scientific value of biomolecular NMR.

PI_NAMEs: HENZLER-WILDMAN, KATHERINE ANNE;RIENSTRA, CHAD M (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3D Print;Acceleration;Address;Algorithms;Amyloid;Amyloid Fibrils;anti-fungal agents;Area;Areca;Automatic Data Processing;Automation;Automobile Driving;base;Benchmarking;Binding;Biological;Biology;Biomedical Research;Biomolecular Nuclear Magnetic Resonance;Biotechnology;Blood coagulation;Calibration;Chad;Chemicals;Chronology;Collaborations;Communities;community engagement;Complex;Computer software;computerized data processing;cost;Costs and Benefits;Custom;Data;data acquisition;Data Analyses;Data Collection;data quality;Dedications;design;Development;Diameter;Disease;Educational workshop;Ensure;Environment;Enzymes;experimental study;Feedback;flexibility;Foundations;Free Energy;Funding;Future;G-Protein-Coupled Receptors;Goals;Grant;graphical user interface;Health;Human Resources;Illinois;improved;In Vitro;innovation;Instruction;Investments;Ionic Strengths;ionization constant;Kinetics;Knowledge;Learning;Lewy Bodies;Ligands;Linux;Magic;Measurement;Mediation;Medicine;meetings;Membrane;Membrane Proteins;Methods;Michigan;Microscopic;Modeling;Modernization;Multienzyme Complexes;Neurodegenerative Disorders;new technology;NMR Spectroscopy;Nucleic Acids;Operating System;Outcome;Pathogenicity;Pathology;Pharmaceutical Preparations;Physiological;Preparation;Procedures;Productivity;programs;protein folding;Proteins;Protocols documentation;Publishing;quantum chemistry;recruit;Reporting;Reproducibility;Research Infrastructure;Resolution;Resources;Rest;Running;Sampling;Science;senior faculty;Services;small molecule;Solid;solid state;solid state nuclear magnetic resonance;Specificity;Speed;Sterols;Structure;Surface;System;Technology;technology development;Technology Transfer;Testing;Thermodynamics;Time;Tissue Sample;tool;Translating;Validation;web site

PROJECT_TITLE: NMR Technologies for Integrating Structure, Function and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(40)R]


NIH_SPENDING_CATS: Biotechnology

PI_NAMEs: RIENSTRA, CHAD M (contact)

PROJECT_TITLE: Administration and Management

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: PROJECT NARRATIVE Most biologists believe that the mammalian heart has a very limited capacity to regenerate, one that is generally not sufficient to sustain functional recovery after a heart attack. Our recent work challenged this principle and instead argued that heart regeneration is variable trait, like height or eye color, with some individuals capable of meaningful repair and others not. The focus of this project is to identify the genes responsible for why some individuals are better at regenerating their hearts than others, the knowledge of which will help us better understand the mechanisms of heart regeneration and design therapeutics to stimulate the process across all patients.

PI_NAMEs: PATTERSON, MICHAELA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Address;Adult;Affect;Animal Model;Belief;Birth;Candidate Disease Gene;candidate identification;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;Cell Cycle;cell regeneration;Cells;Chromosomes;Classification;Clinical;combinatorial;Competence;Complex;Cytokinesis;Data;design;Diploidy;DNA biosynthesis;Evaluation;Eye Color;Failure;Frequencies;gene function;Genes;Genetic;genetic approach;Genetic Epistasis;genome wide association study;genomic locus;HDAC7 histone deacetylase;Heart;heart function;Heart Injuries;Height;Impairment;Individual;Infarction;Injury;innovation;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;loss of function;Mediating;Mononuclear;Mouse Strains;Mus;Myocardial;Myocardial Infarction;Myocardial tissue;Myocardium;Natural regeneration;Nature;novel;Other Genetics;Outcome;overexpression;Patients;permissiveness;Phase;Phenotype;Phosphotransferases;Play;Ploidies;Polyploidy;Postdoctoral Fellow;postmitotic;postnatal;Process;Proliferating;Proteins;Recovery of Function;regenerative;Regenerative response;repaired;RNA;Role;Seminal;senescence;Testing;Therapeutic;trait;Variant;Work;Zebrafish

PROJECT_TITLE: Genetic interactions and multifactorial genetics mediate myocardial regeneration

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: CARBONE, DAVID P. (contact)

PROJECT_TERMS: Abbreviations;Adult;animal imaging;Award;Basic Science;Biological;biomedical informatics;Biometry;Cancer Biology;cancer care;cancer cell;Cancer Center Support Grant;Cancer Control;Cancer Etiology;Catchment Area;Cessation of life;Chemoprevention;Childhood;Clinical;Clinical Treatment;Clinical Trials;Collaborations;college;colon cancer prevention;Colorectal Cancer;Comparative Pathology;Comprehensive Cancer Center;Decision Making;Diagnosis;digital imaging;Direct Costs;Discipline;Disease;Doctor of Philosophy;drug development;Exhibits;Flow Cytometry;Funding;Future;Genomics;Glioblastoma;Goals;Grant;Growth;Head and Neck Cancer;host neoplasm interaction;Immune checkpoint inhibitor;Immune system;Immunogenomics;Immunooncology;Immunotherapeutic agent;improved;innovation;Institution;interest;Intervention;Intramural Research Program;investigator-initiated trial;Journals;leukemia;life span;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of thyroid;Malignant Neoplasms;Medicine;meetings;member;Microscopy;Molecular;Molecular Biology;Molecular Carcinogenesis;Morbidity - disease rate;mortality;multidisciplinary;National Cancer Institute;National Comprehensive Cancer Network;NCI Center for Cancer Research;Non-Small-Cell Lung Carcinoma;Ohio;Oncology;Outcome;pathology imaging;Patients;Pediatric Hospitals;Peer Review;Peer Review Grants;Pharmaceutical Chemistry;Pharmacy facility;Physicians;preclinical study;Prognosis;prognostic;programs;Proliferating;Proteomics;Publications;Publishing;recruit;Research;Research Personnel;Research Priority;Resistance;Resource Sharing;Sarcoma;Scientist;Services;Signal Pathway;small molecule;Solid Neoplasm;The Cancer Genome Atlas;Therapeutic;therapeutic target;Tissues;Training;Translating;translational goal;Translational Research;translational therapeutics;treatment response;tumor;tumor heterogeneity;tumor progression;United States National Institutes of Health;Universities;Validation;Veterinary Medicine

PROJECT_TITLE: Project 05: Translational Therapeutics (TT)


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PI_NAMEs: HENZLER-WILDMAN, KATHERINE ANNE (contact)

PROJECT_TERMS: Activities of Daily Living;Aphorisms;Benchmarking;Biological;biophysical properties;biophysical techniques;Cell Membrane Permeability;Cells;Characteristics;Chemicals;computerized tools;cost;cryogenics;data acquisition;Data Collection;design;Disease;Drug Targeting;Ensure;Environment;experimental study;Formulation;Goals;Hour;Hydration status;Individual;instrument;Integral Membrane Protein;Investments;Ionic Strengths;Ions;Isotope Labeling;Knowledge;Label;Ligands;Light;Lipid Bilayers;Lipids;Liposomes;macromolecule;Magic;magnetic field;Measurement;Measures;Membrane;Membrane Potentials;Membrane Proteins;Methods;Micelles;milligram;Molecular Weight;nanodisk;Nuclear;Persons;pH gradient;Pharmaceutical Preparations;Phase;Physiologic pulse;Physiological;Preparation;Process;protein function;Proton-Motive Force;Recycling;Relaxation;Reproducibility;Resolution;Resources;risk mitigation;Sampling;Scientist;sensor;Series;small molecule;Solid;solid state;solid state nuclear magnetic resonance;solute;Specific qualifier value;structural biology;Structure;success;synergism;Techniques;Technology;technology research and development;Time;Titrations;tool;Training;Tube;Viscosity;voltage;wasting;Work

PROJECT_TITLE: Expanding the Scope of NMR Sample Preparation


NIH_SPENDING_CATS: Aging;Cancer;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Relevance to Public Health Prostate cancer is a heterogeneous disease. Different patients respond to therapies differently and the prognosis varies significantly from patient to patient. The goal of the proposed work is to identify novel biomarkers to help guide treatment and predict prognosis, which is an urgent unmet need. Successful completion of the project has the potential to benefit a large number of patients.

PI_NAMEs: HUANG, JIAOTI  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Adenocarcinoma;advanced disease;advanced prostate cancer;Aggressive behavior;Anabolism;androgen independent prostate cancer;Androgen Receptor;androgen sensitive;Androgens;Animal Model;Biochemical;Biological Markers;Biopsy;cancer cell;Cancer Patient;Castrate sensitive prostate cancer;Castration;Cell Line;Cells;Cessation of life;Clinic;Clinical;cohort;Compensation;Data;Dependence;differential expression;Disease;Enzymes;experience;Glucose;Glutaminase;Glutamine;Glycolysis;Goals;Heterogeneity;Histologic;hormone therapy;Hormones;individual patient;Kidney;Malignant neoplasm of prostate;Malignant Neoplasms;Metabolic;Minority;Molecular;Neoplasm Metastasis;Neuroendocrine Carcinoma;Neuroendocrine Cell;novel marker;Nutrient;Outcome;Oxidative Phosphorylation;Pathologic;patient variability;Patients;personalized biomarkers;potential biomarker;Prediction of Response to Therapy;Process;Prognosis;prostate cancer cell;Prostate Cancer therapy;Prostatectomy;Protein Isoforms;Public Health;Receptor Inhibition;Recurrence;Resistance;Sampling;Specimen;Starvation;targeted treatment;Testing;therapy resistant;treatment response;trend;tumor;Warburg Effect;Work

PROJECT_TITLE: Glutaminase I isoforms as personalized biomarkers of prostate cancer

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Hypertension;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Continuous blood pressure (BP) is one of the most critical monitoring parameters during anesthesia, surgery and in intensive care units (ICU). However, the current gold standard technology for BP monitoring, the invasive arterial line (a-line), causes patient suffering (physical pain) and increases the risk of infection, and current noninvasive BP technologies have poor stability. In this project we will develop novel algorithms and hardware with improved stability to meet the clinical need for noninvasive continuous BP monitoring,

PI_NAMEs: ZHANG, QUAN  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Academia;Accidents;Algorithms;Anesthesia procedures;Annual Reports;Arterial Lines;Benchmarking;Blood;Blood Pressure;Blood Pressure Monitors;Brain;Cardiac Surgery procedures;Catheters;Clinical;Continuity of Patient Care;Data;data format;data fusion;data privacy;data sharing;Databases;deep learning;Development;Electrocardiogram;Ensure;Evaluation;experience;feature extraction;Finite Element Analysis;Future;Goals;Heart;high risk;Hypertension;Hypotension;Impairment;improved;indexing;Individual;Industry;Infection;infection risk;Intensive Care Units;Intervention;invention;Investigation;Kidney;light weight;Machine Learning;Measurement;Measures;Methods;Monitor;monitoring device;mortality;multimodality;novel;Operative Surgical Procedures;Organ;Outcome;Pain;Patient Monitoring;Patient Monitoring System;patient privacy;Patients;Performance;Perioperative;Physiologic pulse;portability;Postoperative Period;privacy protection;Process;public database;Pulse Oximetry;recurrent neural network;Risk;sensor;Signal Transduction;Site;Stream;surgical risk;System;Technology;technology development;Temporal Arteries;Testing;Time;tonometry;Transport Process;ultrasound;United States;United States National Institutes of Health;wearable device;Work

PROJECT_TITLE: Wearable Multi-modality Cuffless Blood Pressure Monitoring

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: Environmental exposures are associated with a host of human diseases. Reversible methylation of RNA controls gene expression, modulates physiologic processes and it is deregulated in benign and malignant disorders. We will test the concept that oxidative stress, by disrupting intermediary metabolism inhibits RNA demethylases, promotes RNA hypermethylation and perturbs gene expression and cell signaling.

PI_NAMEs: AGUIAR, RICARDO C (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: Abnormal Cell;Address;Agreement;Alcohol consumption;alpha ketoglutarate;Antioxidants;Atmosphere;Autoimmunity;B-Cell Lymphomas;B-Lymphocytes;Benign;Biological Process;cancer cell;Chemicals;cigarette smoking;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Consumption;Data;demethylation;Diabetes Mellitus;Dioxygenases;Disease;DNA;Embryonic Development;Environmental Exposure;Environmental Risk Factor;Enzymes;epitranscriptome;Ethanol;Event;Excision;exposed human population;Free Radicals;Gene Expression;Gene Expression Profile;Genetic Models;Growth;histone demethylase;Homeostasis;Human;human disease;Hypermethylation;Impairment;In Vitro;in vitro Model;in vivo;inhibitor;Isocitrate Dehydrogenase;Knowledge;Link;Malignant - descriptor;Malignant Neoplasms;Mediating;Metabolism;Methyltransferase;Mitochondria;mitochondrial metabolism;Mixed Function Oxygenases;Modeling;Modification;mouse model;mutant;Nerve Degeneration;Non-Malignant;novel;Obesity;Oncogenic;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Induction;Oxidoreductase;Pathogenicity;Physiological;Physiological Processes;Play;Poison;pollutant;Property;Radiation;Reactive Oxygen Species;Recurrence;Reporting;RNA;RNA methylation;Role;Secondary to;Signal Pathway;Signal Transduction;stem cell function;Supplementation;System;Testing;transcriptome;Transducers;Ultraviolet Rays;Untranslated RNA;Work

PROJECT_TITLE: Oxidative stress and RNA methylation


PROJECT_TERMS: Acceleration;Amplifiers;automated algorithm;Back;Benchmarking;Calibration;Communities;Complex;Computer software;Data;data acquisition;Data Collection;data exchange;Decision Making;design;Detection;Development;Dimensions;Disease;Electronics;Ensure;Evaluation;experimental study;fabrication;Funding;Future;Generations;Goals;Hour;Illinois;improved;instrument;instrumentation;interest;irradiation;Magic;magnetic field;Maintenance;Measurement;Minor;Modernization;Monitor;Multidimensional NMR Techniques;NMR Spectroscopy;open source;operation;Optics;Outcome;Output;Performance;Physiologic pulse;Procedures;Protocols documentation;Publishing;radio frequency;Ramp;repaired;Reproducibility;Research;Resolution;Sampling;Series;Signal Transduction;solid state nuclear magnetic resonance;Specific qualifier value;Structure;System;Technology;Temperature;Time;timeline;Vendor;wasting;Width

PROJECT_TITLE: Technologies for Solid-State NMR Data Collection


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_NAME: OHIO STATE UNIVERSITY

PI_NAMEs: PASKETT, ELECTRA D. (contact)

PROJECT_TERMS: Abbreviations;Address;animal imaging;Appalachian Region;Area;Asian;Basic Science;biomedical informatics;Biometry;Breast;Breast Cancer Detection;Cancer Biology;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer health equity;Cancer Hospital;cancer research center director;Catchment Area;Chemoprevention;Childhood;Clinical Sciences;clinical trial enrollment;Clinical Trials;Collaborations;Colorectal;Communication;Communities;community advisory board;community engagement;community organizations;Community Outreach;community partners;community partnership;community planning;Comprehensive Cancer Center;County;demographics;design;Development;Diagnosis;Disease;Disparity;Doctor of Philosophy;Education;Education and Outreach;Endometrial;Ensure;extracellular vesicles;Faculty;Feedback;Fostering;Funding;Future;Government;Grant;Health;Healthcare;Human Papilloma Virus Vaccination;Immunologic Monitoring;Immunooncology;improved;Incidence;Institutional Review Boards;interest;International;Intervention;Intramural Research Program;Leadership;Lesbian Gay Bisexual Transgender Queer;leukemia;life span;Logic;Longevity;Lung;Malignant neoplasm of cervix uteri;Malignant Neoplasms;material transfer agreement;member;Minority;Minority Groups;Mission;Modeling;Molecular Carcinogenesis;Monitor;mortality;NCI Center for Cancer Research;Obesity;Ohio;outreach;Patient Care;Patients;Pediatric Hospitals;Policies;Policy Developments;Population;Population Characteristics;Population Heterogeneity;Population Sciences;Prevalence;Prevention;Procedures;programs;Prostate;recruit;Research;Research Institute;Research Personnel;Resource Sharing;Risk Behaviors;Risk Factors;Role;Rural;rural health clinic;screening;Screening for cancer;screening services;service engagement;Services;success;Surveys;Targeted Research;Thyroid Gland;Time;Tobacco use;Translational Research;translational therapeutics;Translations;Underrepresented Populations;underserved community;Universities;Woman;Work

PROJECT_TITLE: Community Outreach and Engagement

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Networking and Information Technology R&D (NITRD)

PI_NAMEs: LEE, WOONGHEE  (contact)

PROJECT_TERMS: 3-Dimensional;Acceleration;Algorithms;Automation;Bayesian Analysis;Benchmarking;beta pleated sheet;Chemicals;Communities;Complex;computerized data processing;computing resources;conformer;Consumption;cost;Cryoelectron Microscopy;Data;data acquisition;Data Analyses;Data Collection;data handling;data integration;Data Set;Detection;Dimensions;Disease;experimental study;Feedback;graphical user interface;high dimensionality;Homology Modeling;Hybrids;improved;Individual;Infrastructure;Intervention;Joints;Label;Machine Learning;Manuals;Membrane Proteins;Methods;Modernization;molecular dynamics;Morphologic artifacts;multidimensional data;multiple datasets;Noise;non-traditional data;parallel computer;Performance;Phase;Preparation;Process;programs;Proteins;reconstruction;Reproducibility;Research;Resolution;Resources;restraint;Roentgen Rays;Sampling;Signal Transduction;solid state nuclear magnetic resonance;Source;Speed;Structural Models;Structure;System;Technology;Testing;three dimensional structure;Time;Titrations;tool;United States National Institutes of Health;Vertebral column;Visualization;Visualization software

PROJECT_TITLE: Integrated NMR for Complex Systems


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE With age humans can accumulate clones of leukocytes in peripheral blood that arise from somatic mutations in bone marrow stem cells: clonal hematopoiesis of indeterminate potential (CHIP). Mutations in DNMT3A or TET2 account for most CHIP, and associate with a striking 2-4 fold excess in atherosclerotic events, but we have little understanding of the underlying mechanisms. This study will investigate in mice bearing CHIP mutations in myeloid cells mechanistic hypotheses about the causality of interleukin (IL)-6 and IL-1 signaling and sex differences in accelerated atherosclerosis in Tet2 and Dnmt3a hypofunction, building on decades of our group's experience with cytokine biology in atherothrombosis in both basic and clinical investigations, an offers strong translational potential.

PI_NAMEs: LIBBY, PETER  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Ablation;Acceleration;Age;Aging;Antibodies;Arterial Fatty Streak;atherogenesis;Atherosclerosis;atherothrombosis;Biology;Blood;Bone Marrow;Bone Marrow Cells;Bone Marrow Stem Cell;cardiovascular risk factor;Cardiovascular system;Cells;Chimera organism;Chimeric Proteins;Clinical;Clinical Data;clinical investigation;cytokine;Data;DNMT3a;Endothelium;Etiology;Event;Evolution;experience;experimental study;Female;genetic variant;Genotype;Gonadal Steroid Hormones;Hematopoiesis;Host Defense;Human;IgG1;IL-6 inhibitor;IL6ST gene;improved;In Situ;Individual;Infection;infection risk;Inflammasome;Inflammation;Inflammatory;Interleukin 6 Receptor;Interleukin-1;Interleukin-1 beta;Interleukin-6;interleukin-6 receptor alpha;Interleukins;Interruption;Lesion;Leukocytes;LoxP-flanked allele;Macrophage;male;Mediator;Messenger RNA;Monitor;Mononuclear;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;novel;Oncology;Organ;Outcome;Pathway interactions;peripheral blood;Phagocytes;Population;preservation;Procedures;Proteins;PTPRC gene;Recurrence;Research;response;Risk;Risk Factors;Role;Science;Sex Differences;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Somatic Mutation;Spleen;targeted treatment;Testing;translational potential;Work

PROJECT_TITLE: Mechanisms and Modulation of Accelerated Atherosclerosis in Clonal Hematopoiesis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Epilepsy;Lung;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Sudden Unexpected Death in Epilepsy (SUDEP) is defined as the sudden, unexpected, and unexplained death of a person with epilepsy and accounts for between 8 and 17% of all epilepsy-related deaths. Increasing evidence supports breathing cessation as a primary cause of death following a seizure. Using a novel mouse model of SUDEP, we propose to elucidate the underlying mechanisms of breathing cessation during and after seizures, possibly creating new therapeutic avenues for SUDEP.

PI_NAMEs: PATEL, MANOJ K (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Address;Apnea;Benchmarking;Bradycardia;Brain Stem;Breathing;Carbon Dioxide;Cardiac;cardiac pacing;Cause of Death;Cell Nucleus;Cessation of life;Clinical;clinically relevant;Complex;Development;Electroencephalography;Electrophysiology (science);Epilepsy;epileptic encephalopathies;expiration;Failure;gain of function mutation;Heart Arrest;heart function;Homeostasis;Impairment;in vivo;ineffective therapies;insight;knock-down;Monitor;mortality;Motor Seizures;mouse model;Mus;Muscle;Mutation;National Institute of Neurological Disorders and Stroke;neural circuit;Neurologic;Neurons;neuroregulation;new therapeutic target;novel;novel therapeutics;optogenetics;Oxygen;Pathology;patient population;Patients;Persons;Phase;Population;prevent;Prevention strategy;Process;Recovery;Refractory;Reporting;Research;Respiration Disorders;respiratory;Respiratory Diaphragm;Risk;Risk Factors;Role;SCN8A encephalopathy;SCN8A gene;Seizures;small hairpin RNA;Sodium Channel;Stroke;sudden unexpected death in epilepsy;Symptoms;Techniques;Testing;Time;Tonic - clonic seizures;ventilation;Viral;Vulnerable Populations;years of life lost

PROJECT_TITLE: Role of brainstem cardiorespiratory neurons in SUDEP

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


PI_NAMEs: WESTLER, WILLIAM MILO (contact)

PROJECT_TERMS: anti-fungal agents;Area;Arizona;Automobile Driving;Back;Beds;Biodiversity;Biological;biological systems;Blood coagulation;Characteristics;chemical synthesis;Chemicals;Collaborations;Complex;Coupling;Data;Data Collection;data integration;Decision Making;Detection;Development;Disease;Electronic Mail;Ensure;Environment;Enzymes;Evaluation;experimental study;Future;Horns;Illinois;improved;innovation;instrument;Ion Channel;Isotopes;Joints;Label;Length;Lewy Bodies;Measurement;meetings;Membrane;Membrane Potentials;Membrane Proteins;Michigan;Motivation;Multienzyme Complexes;new technology;Nucleic Acids;Pharmaceutical Preparations;pre-clinical;Preparation;Procedures;Process;Progress Reports;Property;protein complex;Proteins;Proton-Motive Force;Protons;recruit;Reproducibility;Resolution;RNA;Sampling;Selection Criteria;sensor;Services;Signaling Protein;Site Visit;small molecule;solid state nuclear magnetic resonance;Sterols;Structure;success;symposium;System;Technology;technology development;technology research and development;Telephone;Tertiary Protein Structure;Testing;Texas;Therapeutic;Time;Tissues;Titrations;tool;translational impact;TRP channel;Universities;Validation;voltage;voltage gated channel;Washington

PROJECT_TITLE: Driving Biomedical Projects


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it centers on developing a new 3D image guided based method to deliver laser photocoagulation therapy to the entire retinal periphery for breaks and detachments. Following system development and validation, there is potential for improved early screening and prevention of breaks degrading into detachments necessitating vision-saving surgery which is relevant to the part of the NIH’s mission that pertains to reducing illness and disability.

PI_NAMEs: MCNABB, RYAN P (contact);TOTH, CYNTHIA ANN

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;Address;Adoption;assistive robot;Blindness;Clinic;Clinical;clinical examination;Compensation;Contact Lenses;Cornea;Coupled;Custom;Depressed mood;design;Devices;disability;Disease;Documentation;Early Diagnosis;early screening;Early treatment;Evaluation;experimental study;Eye;Family suidae;Functional disorder;Goals;Image;image guided;imaging system;Imaging technology;Improve Access;improved;in vivo;in vivo imaging;Incidence;innovation;laser photocoagulation;lens;Light Coagulation;Liquid substance;Location;macula;Manuals;Maps;Mechanics;Memory;Mental Depression;Methods;Mission;Modeling;Motion;Operative Surgical Procedures;Ophthalmology;Ophthalmoscopes;Ophthalmoscopy;Optical Coherence Tomography;Optics;Outcome;Patients;Peripheral;Phototherapy;Pilot Projects;prevent;Prevention;Procedures;Public Health;real-time images;Research;Research Proposals;Resolution;Retina;Retinal Detachment;retinal imaging;retinal ischemia;Retinal Perforations;Risk Reduction;Robot;Robotics;Scanning;skills;standard of care;System;Systems Development;Techniques;Technology;Testing;Three-Dimensional Image;Three-Dimensional Imaging;Time;tool;Training;United States;United States National Institutes of Health;Validation;Vision;Visualization

PROJECT_TITLE: Assistive Robotically Aligning Optical Coherence Tomography and Laser Photocoagulation Therapy of the Retinal Periphery


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: Columbus

PI_NAMEs: POLLOCK, RAPHAEL E. (contact)

PROJECT_TERMS: Abbreviations;animal imaging;Award;biomedical informatics;Biometry;Budgets;Cancer Biology;Cancer Center Support Grant;Cancer Control;cancer prevention;Cancer Survivorship;Catchment Area;Chemoprevention;Clinical Research;clinical translation;Clinical Treatment;Clinical Trials;Collaborations;college;Communities;community partnership;Comparative Pathology;Comprehensive Cancer Center;Development;digital imaging;early-career faculty;Engineering;Evaluation;Faculty;Faculty Recruitment;faculty support;Flow Cytometry;Funding;Genomics;Goals;Grant;Growth;Guidelines;Hematologic Neoplasms;Immunooncology;Information Technology;innovation;Institution;Intervention;Intramural Research Program;Investments;leukemia;leukemia tissue bank;Malignant Neoplasms;Medical center;member;Microscopy;mid-career faculty;Molecular Carcinogenesis;NCI Center for Cancer Research;Ohio;pathology imaging;Pediatric Hospitals;Peer Review;Pharmaceutical Chemistry;Population Sciences;Process;programs;Proteomics;recruit;Research;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Development;Resource Sharing;Science;senior faculty;Services;Solid Neoplasm;Strategic Planning;Surveys;translational genomics;Translational Research;translational therapeutics;Universities;Vision

PROJECT_TITLE: Developmental Funds

STUDY_SECTION: NCI