ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Project Narrative This proposal examines a means of providing potent anticoagulation within extracorporeal membrane oxygenation (ECMO) circuits without limiting normal coagulation in a patient’s tissues. To accomplish this, we propose combining polycarboxybetaine surface coatings with a highly selective bicyclic peptide Factor XIIa inhibitor. Together, these should improve survival during ECMO and enable long-term respiratory support outside the intensive care unit.

PI_NAMEs: COOK, KEITH E (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Adsorption;Affect;Albumins;Anticoagulants;Anticoagulation;artificial lung;Binding;Biocompatible Materials;biomaterial interface;Bleeding time procedure;Blood;Blood Platelets;Bolus Infusion;Cessation of life;Chronic lung disease;Clinical;clinical application;clinically relevant;Coagulation Process;Consumption;Custom;Cyclic Peptides;Data;Death Rate;Destinations;Dose;Drops;Effectiveness;efficacy evaluation;Emergency department visit;Engineering;Extracorporeal Membrane Oxygenation;Factor XIIa;Fibrinogen;Formulation;Gases;Goals;Half-Life;Hemorrhage;Heparin;Hour;Human;improved;In Vitro;in vivo;Inflammation;inhibitor;Intensive Care Units;Intravenous;intravenous drip;Life;Mechanical ventilation;Modeling;mortality;nanomolar;Normal tissue morphology;Oryctolagus cuniculus;Outcome;Oxygenators;Patients;Persons;Plasma Proteins;Plasmin;Plasminogen;Polyethylene Glycols;Proteins;Prothrombin time assay;Protocols documentation;Recovery;respiratory;restraint;Safety;sheep extracorporeal membrane oxygenation;Surface;surface coating;System;Technology;Thromboplastin;thrombotic complications;Time;Tissues;Transplantation;Venous

PROJECT_TITLE: Combined Use of Polycarboxybetaine Coatings with a Selective FXIIa Inhibitor to Create Potent Biomaterial Anticoagulation Without Bleeding During Extracorporeal Life Support

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: AMES

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE CRISPR-Cas systems allow bacteria to defend themselves against viruses and have also provided revolutionary tools for improving human health. Defining the mechanisms of CRISPR immunity is required to understand bacterial population dynamics and evolution, and to use CRISPR tools as safely and effectively as possible. Our work will elucidate the structure and function of protein-nucleic acid complexes that play central roles in CRISPR immunity and have important potential for human therapies.

PI_NAMEs: SASHITAL, DIPALI GURUDUTT (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TITLE: Defining mechanisms of diverse CRISPR-Cas complexes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CAMBRIDGE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: The proposed research will define basic mechanisms that regulate neurotransmitter release and retrograde signaling at neuronal synapses. Alterations in synaptic communication have been linked to numerous neurological and psychiatric diseases of the human brain. By defining how synapses bi-directionally communicate, our research will provide a foundation for understanding brain diseases that alter the ability of the synapse to properly signal.

PI_NAMEs: LITTLETON, J. TROY (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Binding Proteins;Binding Sites;Biological Assay;Brain;Brain Diseases;Central Nervous System Diseases;Communication;Complex;CRISPR/Cas technology;Defect;Dendrites;Dense Core Vesicle;Dissection;Drosophila genus;Endocytosis;experimental study;Family;Family member;Foundations;functional outcomes;Genetic;Genetic Screening;Goals;Growth;Homologous Protein;Human;human disease;infancy;Link;Location;Mediating;member;Membrane;Membrane Fusion;Mental disorders;millisecond;Modeling;Molecular;mutant;Mutate;Mutation;Nervous System Disorder;Neuromuscular Diseases;Neuromuscular Junction;neuron development;Neurons;Neuropeptides;neurotransmitter release;Organism;Phase;Positioning Attribute;postsynaptic;Postsynaptic Membrane;presynaptic;Presynaptic Terminals;Process;Protein Family;Proteins;receptor;Recycling;Regulation;Research;Role;Route;sensor;Side;Signal Pathway;Signal Transduction;SNAP receptor;Synapses;synaptic function;Synaptic Membranes;Synaptic plasticity;Synaptic Vesicles;synaptotagmin;syntaxin 4;target SNARE proteins;Testing;Time;trafficking;Translating;vesicular release;vesicular SNARE proteins

PROJECT_TITLE: Characterization of the Drosophila Synaptotagmin Family

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This is the renewal application for the T32 training grant originally known as “Cancer Etiology, Prevention, Detection and Diagnosis,” which is in its 44th year, and which is entitled in the current application “Leveraging innovative technologies in basic and clinical cancer research”. The program has developed a thriving and robust training environment as well as an effective administrative infrastructure that has been very successful in attracting highly qualified trainees to Stanford University to be educated in cancer biology. During the next funding period, we propose to implement a new vision in which we incorporate innovative technologies into cancer research to enhance both the training and the research projects of our predoctoral trainees, helping them to become independent scientists that take research or clinical positions in academia, biotechnology industries, government laboratories, and the clinic, and to ultimately become leaders in the field of cancer biology.

PI_NAMEs: ATTARDI, LAURA D (contact);SAGE, JULIEN

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Stroke

ORG_CITY: LOS ANGELES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: RELEVANCE TO PUBLIC HEALTH Our studies are relevant to the diseased vessels in the brain, so-called cerebral arteriovenous malformation. This study focuses on factors referred to histone deacetylase 2, bone morphogenetic proteins and Notch, and how they communicate with each other to regulate vessel lumen and vessel lining. Understanding how these factors work may lead to new strategies for prevention and treatment of arteriovenous malformation.

PI_NAMEs: YAO, YUCHENG  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Abnormal Endothelial Cell;Affect;Animal Model;Arteriovenous malformation;Back;Blood Vessels;BMP2 gene;Bone Morphogenetic Proteins;Brain;brain arteriovenous malformations;brain endothelial cell;Brain hemorrhage;Cell Differentiation process;Cell model;Cells;cerebrovascular;Child;Communication;Data;Disease;Endothelial Cells;Endothelium;Enhancers;Enzymes;Epigenetic Process;Gene Proteins;Genetic;Genetic Transcription;Hemorrhage;Hereditary hemorrhagic telangiectasia;Histone Acetylation;Histone Deacetylase;histone deacetylase 2;Histone Deacetylase Inhibitor;Histone H3;Histone H4;histone methylation;histone modification;Homologous Gene;Human;improved;inhibitor;insight;Juvenile polyposis syndrome;LoxP-flanked allele;Lysine;Maintenance;malformation;Maps;matrix Gla protein;Mesenchymal;Micrococcal Nuclease;Modeling;mouse model;Mus;Neurologic Deficit;notch protein;novel therapeutic intervention;Physiologic arteriovenous anastomosis;Population;prevent;Prevention strategy;Proteins;Public Health;repaired;Resolution;Role;Signal Induction;Signal Transduction;single-cell RNA sequencing;Specificity;Specimen;System;Targeted Toxins;Technology;Telangiectasis;Testing;Therapeutic;Toxin;Work

PROJECT_TITLE: BMP and Notch crosstalk in cerebral arteriovenous malformations

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Clinical Research;HIV/AIDS;Infectious Diseases;Lung;Microbiome

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE We propose that fungal translocation, defined by detection of 1,3-beta-D-glucan (BDG), occurs in people living with HIV (PWH) in the absence of invasive fungal infection, triggers inflammation, and leads to impaired lung function by stimulating inflammation in circulating leukocytes via the dectin-1 receptor. We will explore the role of BDG in HIV-associated COPD, to assess the relationship between gut and lung epithelial barrier integrity, the fungal mycobiome, and circulating BDG levels, and if circulating BDG levels predict disease progression and systemic immune cell activation in HIV COPD using an established lung cohort and in vitro lung modeling. This project could lead to discovery of novel therapeutics to treat and prevent COPD.

PI_NAMEs: METHE, BARBARA ;MORRIS, ALISON  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: absorption;Acute respiratory failure;Aerodigestive Tract;Aerosols;airway epithelium;antiretroviral therapy;Biological;Biological Assay;Biological Markers;Biological Response Modifiers;C-Type Lectins;Cardiovascular Diseases;Caring;Cell Wall;Cells;Chronic Obstructive Pulmonary Disease;Circulation;Code;cohort;Communities;Data;Dendritic Cells;Detection;Disease;Disease Progression;Epithelial Cells;epithelial injury;Epithelium;exposed human population;Functional impairment;Fungal DNA;fungus;Gene Expression;Genes;gut bacteria;Health;HIV;Human;Immune;immune activation;Impairment;improved;In Vitro;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Inflammatory Response;intestinal fatty acid binding protein;Intestines;Leukocytes;Link;Lung;Lung Diseases;Measures;Microbe;microbial products;Modeling;Molecular;monocyte;mortality;Mucous Membrane;mycobiome;Mycoses;Neurocognitive Deficit;never smoker;new therapeutic target;NF-kappa B;novel;novel therapeutics;Organ;Outpatients;overexpression;pathogen;Pathogenesis;Patients;Pattern;Peripheral;Peripheral Blood Mononuclear Cell;Permeability;Persons;Phenotype;Plasma;polyglucosan;Population;prevent;pulmonary function;pulmonary function decline;Pulmonary Inflammation;Radionuclide Imaging;receptor;receptor for advanced glycation endproducts;Reporter;respiratory morbidity;Respiratory physiology;Respiratory Signs and Symptoms;Role;Signal Transduction;Site;sugar;systemic inflammatory response;Technology;Testing;therapeutic biomarker;Time;Variant;Work;zonulin

PROJECT_TITLE: Relationship of fungal translocation, inflammation, and pulmonary function in HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative: Alzheimer’s disease (AD) dementia is a devastating syndrome of progressive cognitive impairment that generates a staggering burden for patients, families, and health care systems, and for which there are no clinically-available disease-modifying treatments. Disruptions of sleep and rest-wake rhythm are potentially modifiable, increase the risk of cognitive decline, and have been associated with the increased production and reduced clearance of the two proteins thought to be most central to Alzheimer’s disease progression – amyloid-b and tau. By combining newly-available tau PET imaging, functional MRI, neuropsychological testing, and at-home sleep measurements, we will determine if sleep disruption may act as a driver of tau protein accumulation, pathologic network activity, and cognitive decline in a population of people with Mild Cognitive Impairment.

PI_NAMEs: CHHATWAL, JASMEER P (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: actigraphy;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;analysis pipeline;Animals;Attention;Behavior;Biological Markers;Brain;Caregiver Burden;Chronic;Clinical;Cognition;Cognitive;cognitive performance;cohort;Data;Dementia;Deposition;design;Disease;Disease Progression;Equation;Evolution;Factor Analysis;Family;Frequencies;Functional Magnetic Resonance Imaging;Grouping;Healthcare Systems;Home;Human;human data;Imaging Techniques;Impaired cognition;improved;in vivo;indexing;Individual;Inferior;Intervention;Intervention Studies;Link;Magnetic Resonance Imaging;Measurable;Measures;Mediating;Mediator;Memory;memory consolidation;Memory impairment;mild cognitive impairment;Modeling;molecular pathology;Natural History;neocortical;network dysfunction;neural network;Neuropsychological Tests;Neuropsychology;non rapid eye movement;Older Population;Participant;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Performance;Persons;Phase;Pittsburgh Compound-B;Polysomnography;poor sleep;Population;Positron-Emission Tomography;prodromal Alzheimer's disease;Production;Proteins;Public Health;Publishing;rapid eye movement;recruit;REM Sleep;Rest;Risk;Sleep;Sleep Apnea Syndromes;Sleep Architecture;Sleep disturbances;Specific qualifier value;Syndrome;tau aggregation;tau Proteins;therapeutic target;therapy design;Time;Visit;β-amyloid burden

PROJECT_TITLE: Linking Sleep Disruption to Tau Accumulation and Network Dysregulation in Early Alzheimer's Disease

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE We have discovered a critical role for Notch signaling in the regulation of damaging immune responses that mediate graft-versus-host disease, a severe complication of allogeneic bone marrow and hematopoietic cell transplantation. The goal of this research project is to identify the specialized immunological niches that function as the source of Notch ligands after bone marrow transplantation; investigate where precisely transplanted T cells first get exposed to Notch ligands and other critical activation signals; and explore the mechanisms by which short-term Notch inhibition after transplantation can lead to durable protection from graft-versus-host disease. Completion of this project will bring essential new information about Notch signaling in immunobiology and pave the way towards development of therapeutic strategies of Notch inhibition for patients with immune-mediated disorders.

PI_NAMEs: PEAR, WARREN S (contact)

PROGRAM_OFFICER_NAME: NABAVI, NASRIN N

PROJECT_TERMS: Accounting;Acute Graft Versus Host Disease;Alloantigen;Allogenic;Anatomy;Antibodies;Antigens;Autoimmunity;B-Lymphocytes;Bone Marrow;Bone Marrow Transplantation;Cell Communication;Cell Lineage;Cells;chronic graft versus host disease;Complication;cytokine;cytotoxicity;Dangerousness;Data;Development;Disease;Dose;experimental study;Exposure to;Genetic Transcription;Goals;graft vs host disease;Hematopoietic Stem Cell Transplantation;Homing;Homologous Transplantation;Human;Immune;Immune response;Immune system;Immunity;Immunobiology;Immunologics;immunoregulation;Immunosuppression;in vivo;Individual;Infiltration;Inflammatory;Injury;insight;Intestinal Graft Versus Host Disease;Investigation;isoimmunity;Ligands;Maps;Mediating;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;nonhuman primate;notch protein;novel;novel strategies;novel therapeutics;Onset of illness;organ transplant rejection;Pathogenicity;Patients;Pattern;Positioning Attribute;preservation;prevent;Production;programs;radioresistant;receptor;recruit;Regulation;Regulatory T-Lymphocyte;Reporter Genes;Research Project Grants;Role;secondary lymphoid organ;side effect;Signal Transduction;Site;Source;Stromal Cells;T cell response;T-Lymphocyte;Therapeutic;therapeutic development;Time;Transgenes;Transgenic Organisms;translational potential;transplant model;Transplantation

PROJECT_TITLE: Notch Signaling in Alloimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-C(02)M]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Data Science;Dementia;Lewy Body Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: CARLSBAD

ORG_NAME: ADVANCED BRAIN MONITORING, INC.

PHR: There is an urgent need for effective tools to aid in the characterization of Alzheimer’s disease and other dementia subtypes in the earliest detectable stages of the pathophysiological process. Advanced Brain Monitoring’s (ABM) goal, building on our ongoing biomarker research (Phase IIa study), is to provide an inexpensive, non-invasive solution to this problem which combines neurocognitive, electrophysiological (EEG, ECG, & EMG), and sleep-behavior assessment into a single, integrated platform. While this novel toolkit is currently being used in a small group of clinical trials, ABM’s efforts are focused on scaling and expanding the application to be suitable for large-scale drug discovery trials in the endophenotypic stratification of Alzheimer’s and other dementia patients and ultimately used in clinical diagnostics.

PI_NAMEs: BERKA, CHRIS  (contact)

PROJECT_TERMS: Accelerometer;Address;alertness;Algorithms;Alzheimer's Disease;Architecture;Automatic Data Processing;Behavior;Behavior assessment;Biological Markers;Brain;Cause of Death;Characteristics;Classification;classification algorithm;clinical diagnostics;Clinical Research;Clinical Trials;Clinical Trials Cooperative Group;cloud based;cognitive function;cohort;commercial application;commercialization;computerized;Consult;Data;data acquisition;Data Analyses;data repository;Data Set;Dementia;Dementia with Lewy Bodies;Devices;Diagnosis;diagnostic accuracy;Disease Progression;drug discovery;Drug Industry;Electrocardiogram;Electroencephalography;Electrophysiology (science);endophenotype;Frontotemporal Dementia;Goals;Head Movements;Health Personnel;Home;human subject;Impaired cognition;improved;Individual;Infrastructure;Knowledge;large datasets;limb movement;Machine Learning;machine learning algorithm;Malignant Neoplasms;Measures;Memory;mild cognitive impairment;Monitor;neural;Neurocognitive;neurocognitive test;Neurodegenerative Disorders;Neurologic;Neuropsychological Tests;novel;outreach;Parkinson's Dementia;Patients;Performance;Pharmacologic Substance;Phase;Probability;Process;REM Sleep Behavior Disorder;Reporting;Research;Research Personnel;retention rate;scale up;Secure;Site;Sleep;Sleep Architecture;sleep behavior;Small Business Innovation Research Grant;Statistical Models;Stratification;Study Subject;synucleinopathy;System;Systems Integration;Techniques;Technology;Technology Assessment;technology platform;Testing;Time;tool;Training;Universities;Visit;wireless

PROJECT_TITLE: Multi-site longitudinal Integrated Neurocognitive and Sleep-Behavior Profiler for the Endophenotypic Classification of Dementia Subtypes (INSPECDS)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Local field potential (LFP) created by the synchronized synaptic currents is widely used to characterize network dynamics and circuit functions in healthy and diseased brains. We developed a technique that allows a highly nuanced analyses of the LFP dynamics and reveals a new level of the LFP’s structure: a set discrete, slowly varying oscillatory processes—the oscillons—embedded in a weak noise background. Our goal is to record, to analyze and to manipulate the oscillons in the hippocampal network of WT and AD rodents to gain a better insight into the circuit mechanisms of AD.

PI_NAMEs: DABAGHIAN, YURI ALEXANDER (contact);JI, DAOYUN

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: Abbreviations;Affect;Age;age group;Alzheimer's Disease;Alzheimer's disease model;Animals;APP-PS1;Architecture;Behavior;Biological;Brain;Brain Diseases;Cessation of life;Characteristics;cognitive process;Complex;Coupling;Data;Data Analyses;Dedications;Disease Progression;Elements;epileptiform;extracellular;Frequencies;Genotype;Goals;gravitational wave;Hippocampus;Individual;insight;learned behavior;Learning;lens;life span;Link;Magnetic Resonance;Memory;Methodology;Methods;middle age;Molecular;mouse model;Mus;Nature;Nerve Degeneration;neuron component;Neuronal Dysfunction;Neurons;Noise;non rapid eye movement;novel;Pathology;Patients;Pattern;Performance;Physiological;Population;Process;Property;Quality of life;rapid eye movement;Rat Transgene;Rattus;Research;Rodent;Rodent Diseases;sex;Signal Transduction;Sleep;Source;Structure;Synapses;Techniques;Testing;Thinness;Time;Transgenic Organisms;Work

PROJECT_TITLE: Waves and noise in hippocampo-cortical circuit: a study of Alzheimer's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE (Public Health Relevance)  Mycobacterium tuberculosis (M.tb), the cause of human tuberculosis, is largely composed of waxes (lipids) that our immune system “sees” with the help of T cells. Whole cell mycobacterial vaccines currently under development also contain these lipids, but we do not yet know if lipid-specific T cells contribute to protective immunity induced by vaccination. Here, we will develop tools to study these T cells in small and large animal models and test the hypothesis that lipid-specific T cells provide protective immunity against M.tb. !

PI_NAMEs: SESHADRI, CHETAN  (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: Address;Adoptive Transfer;Adult;Aerosols;Animal Model;Animal Testing;Animals;antigen binding;Antigen Targeting;Antigen-Presenting Cells;antigen-specific T cells;Antigens;antimicrobial;Autoimmunity;Bacille Calmette-Guerin vaccination;BCG Live;BCG Vaccine;Binding;Cause of Death;CD1 Antigens;Cell Wall;Cells;Cessation of life;Child;clinical efficacy;Communicable Diseases;Communities;Computational Technique;Computing Methodologies;Core Facility;Cutaneous;Data;Development;Disease;efficacy study;efficacy testing;epidemic response;Epitopes;experimental study;Flow Cytometry;Foundations;Frequencies;Funding;Glycolipids;Goals;Histocompatibility;Human;Immune system;Immunity;Infection;infectious disease model;Intravenous;Jurkat Cells;lentivirally transduced;Licensing;Lipids;Lung;Macaca mulatta;Malignant Neoplasms;Mediating;Memory;Modeling;mouse model;Mus;mycobacterial;Mycobacterium bovis;Mycobacterium Infections;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Mycolic Acid;nonhuman primate;novel vaccines;Pathogenesis;Peptides;Phase;Phenotype;Predisposition;prevent;Proliferating;Proteins;public health relevance;Pulmonary Tuberculosis;Research;Role;Route;Sorting;Specificity;Stains;Study models;System;T cell response;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Testing;Tissues;tool;Transgenic Mice;Transgenic Organisms;Tuberculosis;tuberculosis immunity;Tuberculosis Vaccines;United States National Institutes of Health;unvaccinated;Vaccinated;Vaccination;vaccine-induced immunity;Vaccines;Waxes;Whole Cell Vaccine

PROJECT_TITLE: The Role of Lipid-specific T cells in Mediating Protection Against M. tuberculosis

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BALTIMORE

ORG_NAME: LIEBER INSTITUTE, INC.

ORG_STATE: MD

PHR: Autism Spectrum Disorder is a chronic debilitating disorders with relatively unknown etiology or pathophysiology. We are proposing to identify pathophysiology by using cellular and animal model of Pitt Hopkins Syndrome, a rare Autism Spectrum Disorder. Electrophysiology, cell biology, imaging, behavior, and molecular analyses will be applied to these models to discover associated pathophysiology and molecular mechanisms for the development of new therapeutic treatments.

PI_NAMEs: MAHER, BRADY J (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Adult;Animal Model;Anxiety;Attentional deficit;autism spectrum disorder;autism symptoms;autosomal dominant mutation;Award;Behavior;Behavioral;Biological Assay;Biological Models;Biological Process;Biology;Brain;Caring;causal variant;Cell Differentiation process;cell fate specification;Cell model;Cells;Cellular biology;Central Nervous System;Child;Childhood;ChIP-seq;Chronic;Classification;Clinical;Communication;comorbidity;Complex;Data;design;Development;Developmental Process;Diagnosis;Disease;disease model;disease phenotype;disease-causing mutation;Electrophysiology (science);Epilepsy;Etiology;experimental study;Family;Functional disorder;functional improvement;Gene Expression Profile;gene function;Genes;Genetic;Genetic Heterogeneity;Genetic Transcription;genetic variant;Goals;Grant;Human;Human Genetics;human model;Image;improved;In Vitro;in vitro Model;induced pluripotent stem cell;insight;Intellectual functioning disability;Knock-out;Knowledge;Lead;Mental Depression;migration;model of autism spectrum disorder;Modeling;Molecular;Molecular Analysis;mouse model;Mus;mutant;Mutate;Mutation;Myelin;myelination;neural;Neurobiology;neuron development;Neurons;neuropsychiatric disorder;novel;novel therapeutics;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Outcome;Pathway interactions;patient derived induced pluripotent stem cells;Patients;PF4 Gene;pharmacologic;Pharmacotherapy;Phenotype;Physiological;Physiology;Pitt-Hopkins syndrome;postnatal;precursor cell;predictive signature;programs;Psychiatry;Public Health;Regulation;Research;Risk;risk variant;Role;Sleep Disorders;Socialization;Therapeutic Intervention;therapeutic target;transcription factor;transcriptome sequencing;Translating;viral rescue

PROJECT_TITLE: Cellular and Molecular Analysis of the Psychiatric Risk Gene Transcription Factor 4 (TCF4)


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Climate-Related Exposures and Conditions;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Pediatric;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Project Narrative: Revitalizing Informal Settlements and their Environments (RISE) is a cluster randomized control trial of a water infrastructure intervention which is currently underway in 24 urban slum communities in Indonesia and Fiji, two countries at high risk for arbovirus transmission and climate change. In my K32 project, I will leverage the RISE platform to evaluate risk factors for dengue and chikungunya infections, test the impact of this intervention on transmission, and create a mathematical model to investigate transmission patterns under a range of climate and intervention scenarios. These studies will lay the groundwork for developing future arbovirus prediction and adaptation strategies and launch my career in emerging infectious disease epidemiology.

PI_NAMEs: ROSSER, JOELLE IVY (contact)

PROGRAM_OFFICER_NAME: GALIVO, FEORILLO HERRERA

PROJECT_TERMS: 5 year old;Address;Aedes;Arbovirus Infections;Arboviruses;Blood specimen;Breeding;Calibration;career;career development;chikungunya;Chikungunya fever;chikungunya infection;Chikungunya virus;Child;Circulation;Climate;climate change;climate data;climate zone;Collection;Communicable Diseases;Communities;cost;Country;Culicidae;Data;Dengue;Dengue Infection;Dengue Virus;design;Development Plans;Diagnostic;Disease;disease transmission;Drainage procedure;Droughts;Emerging Communicable Diseases;Enrollment;Environment;Environmental Risk Factor;Enzyme-Linked Immunosorbent Assay;Epidemiology;Evaluation;experience;Exposure to;Fiji;Floods;Foundations;Future;future climate scenario;global health;Goals;Habitats;high risk;Hot Spot;Household;Image;Immunoglobulin G;Incidence;Indonesia;Infection;infection rate;Infectious Disease Epidemiology;infectious disease model;Infrastructure;innovation;Insecticides;Interdisciplinary Study;Intervention;Island;Knowledge;Laboratories;Life;Life Cycle Stages;Light;mathematical model;Measures;Mentorship;Modeling;Modification;Nested Case-Control Study;novel;outbreak prediction;Pacific Islands;Pathway interactions;Pattern;Physicians;predictive modeling;programs;prototype;Randomized, Controlled Trials;Recommendation;Research;Resistance;Risk;Risk Factors;Running;Serology test;seropositive;Site;Slum;Source;Surveillance Modeling;Surveys;System;Testing;Training;transmission process;Tropical Medicine;Vaccines;vector control;Virus;Water;water environment;World Health Organization;Yellow fever virus;ZIKA;zika fever;Zika Virus

PROJECT_TITLE: Arbovirus Prediction and Mitigation in the Indo-Pacific

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ADMINISTERING_IC: DK

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases;Food Allergies;Pediatric

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that causes distressing symptoms in children. Current gold standard diagnosis relies on histopathological assessment of random biopsies to confirm diagnosis, but the patchy nature of the disease tremendously affects the accuracy. Endoscopic Raman spectroscopy can address this issue by providing an in vivo diagnostic tool to survey the biochemical changes of the esophagus and identify key inflammatory biomarkers indicative of active EoE.

PI_NAMEs: MAHADEVAN-JANSEN, ANITA  (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: Academic Medical Centers;Address;Affect;Allergens;Biochemical;Biochemical Markers;Biological Markers;Biopsy;Child;Childhood;chronic inflammatory disease;Classification;classification algorithm;Clinical;Computer Models;Consumption;Coupled;Custom;data fusion;Deglutition;design;Detection;Development;Devices;Diagnosis;diagnosis standard;diagnostic tool;Disease;Disease Progression;Distress;Endoscopes;Endoscopy;Eosinophilic Esophagitis;Epithelium;Esophageal Diseases;Esophageal Tissue;Esophagogastroduodenoscopy;Esophagus;ex vivo imaging;feeding;Fingerprint;Food;Gastroesophageal reflux disease;Glycogen;Goals;Growth;Histologic;Histology;Image;imaging system;improved;In Situ;in vivo;in-vivo diagnostics;ineffective therapies;Inflammation;Inflammatory;inflammatory marker;Institutional Review Boards;Light;light scattering;Lipids;machine learning classification;Maps;Measurement;Measures;Mediating;Metabolic;Methods;Microscope;Modeling;Molecular;Molecular Profiling;Monitor;Monte Carlo Method;multimodality;multiphoton microscopy;Nature;novel;novel diagnostics;Nucleic Acids;Operative Surgical Procedures;Optics;Outcome;Participant;patient response;Patients;Pediatric Hospitals;pediatric patients;Performance;point of care;Prediction of Response to Therapy;Procedures;Process;Property;prospective test;Proteins;Raman Spectrum Analysis;response;Schedule;Spatial Distribution;Specimen;Surveys;Symptoms;System;Techniques;Technology;Time;time use;tissue biomarkers;tissue phantom;Tissues;Treatment outcome;treatment response;United States;Visit;Vomiting;Water

PROJECT_TITLE: Dual-wavelength endoscopic Raman probe for eosinophilic esophagitis

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Genetics;Human Genome;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease of premature infants and the pathogenesis is not well understood. This proposal will define the epigenomic phenotype of NEC using whole genome bisulfite sequencing to improve our understanding of the pathologic mechanisms involved in the disease and drive the development of new screening tools to identify infants at high risk for the development of NEC.

PI_NAMEs: GOOD, MISTY L (contact);PETERS, DAVID GERARD

PROGRAM_OFFICER_NAME: LOH, KATRINA SHUEH WEN

PROJECT_TERMS: abdominal distension;Abdominal Radiography;Affect;Age of Onset;Air;Antibiotics;biobank;Biological;Biological Assay;Biological Markers;Biology;bisulfite sequencing;Blood;Blood specimen;Body System;Case/Control Studies;Cell Differentiation process;cell free DNA;Cell Lineage;Chemicals;Clinical;Clinical Data;Complication;course development;Data;Death Rate;Detection;Development;Diagnosis;Diagnostic Procedure;diagnostic strategy;Disease;DNA;DNA Methylation;DNA Methylation Inhibition;Early Diagnosis;Economic Burden;Enterocytes;Environmental Risk Factor;Epigenetic Process;epigenome;epigenomics;Excision;Feces;feeding;Gastrointestinal Diseases;Genetic;Genetic Transcription;genome-wide;genomic data;Growth;Hematopoietic;high risk;human tissue;Hypermethylation;improved;Infant;Infection;Inflammatory Response;innovation;insight;intestinal injury;Intestines;Lasers;Leukocytes;liquid biopsy;Maps;medication administration;Metadata;Methods;Methylation;microbiome;molecular phenotype;Morbidity - disease rate;mortality;mouse model;Necrosis;Necrotizing Enterocolitis;Neonatal;neonatal mice;Non-Invasive Detection;novel;novel marker;Onset of illness;Operative Surgical Procedures;Organ failure;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Phenotype;postnatal development;precision medicine;predictive tools;Predisposition;premature;Premature Infant;Premature Infant Diseases;prevent;prognostic tool;prospective;Regimen;Regulation;Reproducibility;Resected;Resources;Risk;Sampling;screening;Screening procedure;single-cell RNA sequencing;Specimen;stool sample;Testing;Time;transcriptomics;Uterus;whole genome

PROJECT_TITLE: Non-invasive analysis of methylated cell free DNA in necrotizing enterocolitis

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Essential tremor (ET) is the most common movement disorder and how tremor is generated in ET patients is poorly understood. Currently, the treatment options for ET are very limited; therefore, many people with ET are impaired in their personal and professional lives. The proposed research will take the recent genetic and neuropathological discoveries of ET into functional understanding how structural and molecular changes in the brain can lead to tremor, and the knowledge gained will serve as foundation for therapy development to slow down the disease progression and to prevent disability.

PI_NAMEs: KUO, SHENG-HAN  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acceleration;Address;Age;Amino Acid Transporter;Animal Model;Astrocytes;Autopsy;Brain;brain circuitry;Cerebellum;Clinical;Data;Dendrites;disability;Disability prevention;Disease;Disease Progression;Distal;Down-Regulation;Electrophysiology (science);emerging adult;Essential Tremor;Excitatory Amino Acids;Excitatory Synapse;Family history of;Fiber;Foundations;Genetic;genome wide association study;Glutamates;Handedness;Heritability;High Prevalence;Human;Impairment;Intention Tremor;knock-down;Knowledge;Mediating;Molecular;mouse model;Movement Disorders;Mus;Mutation;Nervous System Disorder;Neurons;neuropathology;novel;old mice;overexpression;Pathologic;Pathology;Patients;Persons;pharmacologic;Population;Predisposition;prevent;Public Health;Purkinje Cells;Research;Role;selective expression;Severities;Speed;Stimulus;Structure of purkinje fibers;Synapses;Synaptic Transmission;targeted treatment;Testing;Therapeutic;therapeutic development;therapy development;Time;Tremor;United States National Institutes of Health;Up-Regulation;uptake;Viral

PROJECT_TITLE: Targeting Cerebellar Excitatory Synapses for Tremor Progression


ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Although population mixture or admixture is pervasive through human evolution, we still lack adequate statistical methods to study its functional and evolutionary impact. Our goal in this proposal is to develop a suite of computational methods to characterize the local genomic structure of admixed populations and use this information for a range of applications from gene mapping to reconstructing ancestral genomes. These tools will help to analyze data from admixed groups as efficiently as homogeneous populations, and provide novel insights into the genetic and phenotypic legacy of admixture in human evolution.

PI_NAMEs: MOORJANI, PRIYA  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Address;Admixture;admixture mapping;Algorithms;Architecture;Candidate Disease Gene;Chromosome Mapping;Classification;Complex;computational suite;Computer software;Computing Methodologies;Data;Disease;Evolution;fitness;Genes;Genetic;Genetic Variation;Genome;genomic data;Genomics;Goals;Historical Demography;Human;Human Genetics;insight;large datasets;Latinx;Machine Learning;Maps;Methods;Modeling;Mutation;novel;Pathway interactions;Pattern;Phenotype;Play;Population;Research;Research Personnel;Role;Shapes;South Asian;Statistical Methods;Structure;Surveys;tool;trait;Variant

PROJECT_TITLE: Genomic Insights into Human Population Mixture and its Role in Adaptation and Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Vaccine Related

PHR: Narrative HIV persists on antiretroviral therapy (ART) in clonally expanded CD4 T-cells carrying replication- competent proviruses (termed repliclones), which are capable of producing infectious virus and viremia that is not suppressible with ART. The mechanisms involved in clonal outgrowth, persistence and escape from immune-mediated clearance are not defined. Accordingly, we will investigate the mechanisms of clonal persistence including latency, viral escape mutations to antibodies and cytotoxic T-lymphocytes, and intrinsic clonal resistance to immune-mediated killing, in an effort to gain insight on designing strategies that eliminate repliclones and accelerate progress towards a cure for HIV infection.

PI_NAMEs: HALVAS, ELIAS K. (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acceleration;Antibodies;antibody-dependent cell cytotoxicity;antiretroviral therapy;Autologous;Biological Assay;Blood;Case Study;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell killing;Cells;Clinical;Clonal Expansion;Clone Cells;Collaborations;cytotoxic;Cytotoxic T-Lymphocytes;Data;design;DNA;Epitopes;Evaluation;Failure;Gene Silencing;Genetic Transcription;genome sequencing;HIV;HIV envelope protein;HIV Infections;HIV Seropositivity;HIV-1;Immune;immune clearance;Immune Evasion;Immune response;Immune system;Immunology;Individual;Infection;insight;Investments;Laboratories;Maps;Measurement;Mediating;Medicine;Messenger RNA;Methods;Mutate;Mutation;Natural Killer Cells;neutralizing antibody;neutralizing monoclonal antibodies;new technology;novel;Plasma;Production;Productivity;Proliferating;Proviruses;Reporting;Resistance;response;RNA;RNA Splicing;T cell response;Therapeutic;therapeutic development;tool;Universities;Variant;Viral;viral rebound;Viremia;Virion;virology;Virus;Work

PROJECT_TITLE: Understanding Immune Evasion by HIV-1 Repliclones

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Bacterial toxins that target insects could be utilized for developing bio-pesticides to control harmful insects, but a molecular understanding of toxin-host interactions is required. Here, we seek to establish and validate new methods and tools for carrying out unbiased genome-wide screens on insect cell models to uncover key host factors mediating the action of insect- targeting bacterial toxins.

PI_NAMEs: DONG, MIN  (contact);PERRIMON, NORBERT

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Bacterial Toxins;Bacteriophages;Cell Line;Cell model;Cells;Communicable Diseases;Communities;CRISPR screen;CRISPR/Cas technology;Culicidae;Dengue;design;Development;Drosophila genus;Drosophila melanogaster;experimental study;Family;Family member;fly;Future;Genetic Recombination;genome wide screen;genome-wide;Goals;Guide RNA;Human;human disease;human pathogen;In Vitro;in vivo;Insecta;Insecticides;Integration Host Factors;knock-down;Knock-out;Knowledge;lentivirally transduced;Lentivirus;Libraries;Life Cycle Stages;Lyme Disease;Malaria;Mammalian Cell;Mediating;member;Methods;Modeling;Molecular;mosquitocidal;Mucins;Nematoda;novel;pathogen;Pathogenesis;pathogenic bacteria;Plasmids;Proteins;prototype;receptor;recombinase-mediated cassette exchange;RNA library;Role;Series;Site;Small Interfering RNA;Specificity;success;System;Targeted Toxins;Technology;tool;Toxic effect;Toxin;transmission process;Validation;vector;Virulence Factors;West Nile;Xenorhabdus luminescens;ZIKV disease

PROJECT_TITLE: Genome-wide CRISPR-Cas9 screens in insect cells to characterize insecticidal toxins

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: BIOLOGY

PHR: Project narrative Acute myeloid leukemia (AML) is highly aggressive, and over 70% of patients with AML eventually become refractory to chemotherapy and face a dire prognosis. There is a sorely unmet need to develop more effective immunotherapy to improve AML therapy. Our proposed studies to develop the nanobody-directed, bispecific and inducible CAR T approach aims to establish a novel and safe CART system to cure AML.

PI_NAMEs: HUA, XIANXIN  (contact)

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adoptive Immunotherapy;Adult Acute Myeloblastic Leukemia;alanine aminopeptidase;Animal Model;B-Cell Acute Lymphoblastic Leukemia;Binding;Blast Cell;cancer cell;CD19 gene;Cell Line;Cell Surface Proteins;Cells;Chemoresistance;chemotherapy;chimeric antigen receptor;chimeric antigen receptor T cells;Clinic;Clinical Research;Data;Development;Disease remission;Drug resistance;effective therapy;Face;FDA approved;Future;Generations;Hematopoietic;Hematopoietic stem cells;Human;IL3RA gene;Immune;Immune system;Immunotherapy;improved;In Vitro;in vivo;innovation;leukemia;leukemia treatment;Leukemic Cell;leukemic stem cell;Lymphoblastic Lymphoma;Medical;mortality;Mus;nanobodies;Normal Cell;Normal tissue morphology;novel;patient derived xenograft model;Patients;pre-clinical;Prognosis;receptor;Refractory;Relapse;Safety;Specificity;Specimen;Surface;System;T-Lymphocyte;Technology;Testing;Toxic effect;Translations;tumor

PROJECT_TITLE: Novel CART Cells for Treating AML

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Data Science;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

PHR: Project Narrative Recent research suggests that the findings from neurodevelopmental research intended to explain adolescent risk-taking behaviors (such as substance use) may not be generalizable. A more robust understanding of the brain systems involved in adolescent risk-taking would contribute to more effective research, intervention(s) and policy decisions. By integrating three adolescent functional magnetic resonance imaging (fMRI) samples, this project will involve training in understanding the effects of analytic flexibility in fMRI, how analytic flexibility affects the construct validity of fMRI tasks and the use of advanced data analysis methods to understand brain- behavior relationships across adolescent samples.

PI_NAMEs: DEMIDENKO, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Adolescence;Adolescent;Adolescent Risk Behavior;adolescent substance use;Affect;Affective;Algorithms;Attention;Behavior;behavior prediction;behavioral phenotyping;Brain;brain based;brain behavior;Brain region;Characteristics;Code;Cognitive;cognitive neuroscience;Communities;Data;Data Analyses;Data Set;Decision Making;design;Detection;Development;dimension reduction;Dimensions;Disparate;Emotional;Fellowship;flexibility;Freedom;Functional Magnetic Resonance Imaging;Goals;Growth;high dimensionality;improved;interest;Intervention;Linear Models;Literature;Machine Learning;Maps;Measurement;Measures;Methodology;Methods;Modeling;Modernization;Motivation;Multivariate Analysis;Negative Valence;neural;neuroimaging;neuromechanism;Neurosciences;open data;Output;Parameter Estimation;Policies;Positive Valence;predictive modeling;Preparation;Process;Protocols documentation;Reproducibility;Reproduction;Research;Research Personnel;Resources;response;Rewards;Sampling;Specific qualifier value;substance use;System;Techniques;Testing;Training;Validation;Variant;Work

PROJECT_TITLE: Improving the Measurement of Brain-Behavior Associations in Adolescence


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Digestive Diseases;Infectious Diseases;Patient Safety;Pediatric

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Appendicitis is the most common surgical condition affecting children, with perforated appendicitis associated with longer hospitalizations, higher hospital readmission rates, worse postoperative outcomes, and higher costs. Photodynamic therapy, which exerts antimicrobial activity through generation of reactive oxygen species, is an appealing adjunct to standard of care therapy that could drastically reduce hospital stay and complications. This study will investigate the use of photodynamic therapy to treat intra-abdominal infections resulting from perforated appendicitis in a rabbit model, as well as against bacteria cultured from samples collected during standard of care human appendectomy.

PI_NAMEs: BARAN, TIMOTHY M (contact);WILSON, NICOLE APRIL

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Abdominal Abscess;Abdominal Infection;Abscess;Acute;Adult;Affect;Alternative Therapies;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Appendectomy;Appendicitis;aspirate;Bacteria;bacterial resistance;Biological;Child;Childhood;Clinical;Clinical Trials;comparative efficacy;comparison control;Control Animal;cost;Cost Savings;Data;design;Diagnosis;Dose;Evaluation;Generations;Goals;Greater sac of peritoneum;gut microbiota;Healthcare;high reward;high risk;Hospital complications;Hospitalization;Human;In Vitro;in vivo;Inflammation;Intra-abdominal;Length of Stay;Light;Lighting;Methylene blue;microbial;Microbial Biofilms;Modeling;Morbidity - disease rate;Operative Surgical Procedures;Organism;Oryctolagus cuniculus;Outcome;Pathologic;patient population;Patients;pediatric patients;Perforated Appendicitis;Perforation;Peritoneal Fluid;Pharmaceutical Preparations;Phase I Clinical Trials;Population;Postoperative Period;Progressive Disease;Prospective Studies;PUVA Photochemotherapy;Reactive Oxygen Species;readmission rates;Recovery;Resistance;resistant strain;Resources;safety and feasibility;Sampling;Specimen;standard of care;Time;Translating;United States;Variant

PROJECT_TITLE: Photodynamic therapy for perforated appendicitis

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is the most common form of dementia in humans, yet there is no cure for AD and the increasing incidence of AD in developed countries poses a tremendous cost to society as lifespans increase. There are two forms of AD, those that have genetic determinants and those that arise sporadically upon aging and comprise the vast majority (~95%) of new AD cases diagnosed. Given that alterations in brain mitochondria appear early in the development of sporadic AD, we propose studies to further characterize the role of ECSIT, a key regulator of mitochondrial function in the development of AD.

PI_NAMEs: ARANCIO, OTTAVIO ;GHOSH, SANKAR  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: AD transgenic mice;Affect;age related;Aging;Alzheimer associated neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Animals;Appearance;Architecture;Attenuated;Autophagocytosis;Autopsy;Behavior;Biology;Brain;Calcium;catalase;cell injury;Cells;Central Nervous System;Cognitive;Cognitive deficits;cohort;Collaborations;Complex;cost;Data;Defect;Dementia;Developed Countries;Development;Diagnosis;Disease;Disease Progression;Down-Regulation;Etiology;Event;Exhibits;experimental study;extend lifespan;Functional disorder;Generations;Genetic Determinism;Homeostasis;Human;Impairment;Incidence;insight;Institution;Laboratories;Link;LoxP-flanked allele;Macrophage;Memory impairment;Metabolism;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Motility;mouse model;Mouse Strains;Mus;Mutation;Names;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;neuropathology;New York;Oxidation-Reduction;oxidative damage;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Phenotype;Physiological;Play;Predisposition;presenilin-1;Principal Investigator;Production;Proteins;Quality Control;Reactive Oxygen Species;Regulation;Research;Respiration;Respiratory Chain;Role;Sampling;Series;Societies;stressor;Susceptibility Gene;Swedish mutation;Symptoms;Synapses;System;tau Proteins;Testing;Therapeutic;transgene expression;transgenic model of alzheimer disease;uptake

PROJECT_TITLE: Understanding the role of ECSIT in neurodegeneration and Alzheimer's Disease


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: A Bio-inspired Latent TGF- Conjugated Scaffold for Patient-specific Cartilage Regeneration Project Narrative While transforming growth factor beta (TGF-) has become one of the most widely utilized mediators to promote tissue engineered cartilage growth, current state-of-the-art delivery platforms are tailored for the administration of highly supraphysiologic doses, which are associated with the induction of pathologic cellular processes (fibrosis, hypertrophy, hyperplasia) that can limit tissue quality and thus the performance of the tissue graft in situ. This proposal investigates a novel, bio-inspired delivery platform, consisting of: 1) the delivery of TGF- to cells in its native latent form, which achieves a beneficial, controlled activity, akin to that during native cartilage development, and 2) the use of patient-specific reaction-diffusion models to guide latent TGF- scaffold design parameters in order to achieve optimal activity doses for individual patients. The delivery of model-optimized TGF- activity levels can yield critical improvements to tissue quality, thus improving clinical outcomes for engineered cartilage regeneration.

PI_NAMEs: ALBRO, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acceleration;Anabolism;Animals;articular cartilage;Autologous;Autologous Transplantation;Binding;Bioreactors;bioscaffold;Cartilage;cartilage development;cartilage regeneration;cartilage repair;cartilaginous;Cell Fraction;Cell Physiology;Cells;Cellular Morphology;chemical reaction;Chondrocytes;Clinical;Defect;Degenerative polyarthritis;design;Development;Diffuse;Diffusion;Dose;efficacy evaluation;Encapsulated;Engineering;Environment;Enzymes;Equilibrium;Exhibits;expectation;experimental study;Exposure to;Extracellular Matrix;Failure;Family suidae;Fibrocartilages;Fibrosis;Generations;Growth;Growth Factor;Health;Human;Hyaline Cartilage;hydrogel scaffold;Hyperplasia;Hypertrophy;Implant;implantation;improved;In Situ;In Vitro;in vivo;individual patient;innovation;Integrins;Kinetics;mechanical properties;Mechanics;Mediator;Methods;Modeling;Molecular;Morphology;novel;osteochondral tissue;Outcome;Pathogenicity;Pathologic;Pathology;Patients;Penetration;Performance;Phase;Phenotype;Physiological;Population;predictive modeling;Process;Protocols documentation;Reaction;Regenerative Medicine;repaired;Residual state;scaffold;Series;Site;Source;Stress;success;Supplementation;Synovial joint;Synovitis;System;Time;Tissue constructs;Tissue Engineering;Tissue Grafts;tissue repair;Tissues;Transforming Growth Factor beta;Transplantation;treatment strategy

PROJECT_TITLE: A Bio-inspired Latent TGF-beta Conjugated Scaffold for Patient-specific Cartilage Regeneration

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The Einstein-Nathan Shock Center of Excellence is part of the biggest Institute in the world for the study of the biology of aging , encompassing approximately 80 labs, which have emerged to stimulate the investigator intellectual environment for specific fields of research and to provide technology that is not practicable for the individual scientist. With support for three research resource cores, pilot & feasibility awards, a designated mentor system, program enrichment and a yearly mini-retreat, this Einstein-Nathan Shock Center will continue to transform the field with the goal to delay human aging and its associated diseases.

PI_NAMEs: BARZILAI, NIR J (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Aging;Area;Autophagocytosis;Award;Biological;Biological Assay;biological research;Biology of Aging;Cells;Clinical Trials;Collaborations;Complex;Crowns;Data;Direct Costs;Disease;Drug Design;drug development;drug discovery;Drug Targeting;Elderly;Ensure;Environment;Epigenetic Process;Exclusion;exome sequencing;experimental study;Feasibility Studies;Fostering;functional decline;Funding;Future;Genetic;Genomics;Geroscience;Goals;Grant;Growth;hallmarks of aging;healthspan;healthy aging;Human;Human Biology;Human Resources;Individual;Inflammaging;innovation;Institution;Investments;Journals;Longevity;Measures;meetings;member;Mentors;Metabolism;metabolomics;Methodological Studies;Mission;multiple omics;Natural regeneration;Nature;novel therapeutics;Organism;Outcome;Paper;Parabiosis;Phenotype;Physiology;Pilot Projects;Price;programs;Proteomics;proteostasis;Public Health;Publications;Quality Control;Reagent;recruit;Research;Research Activity;research and development;Research Personnel;Research Support;Resources;Rodent;Sampling;Science;Scientist;Services;Shock;stem cells;success;System;Technology;Training;transcriptomics;Translating;United States National Institutes of Health

PROJECT_TITLE: Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging


NIH_SPENDING_CATS: Aging

PI_NAMEs: ARIAS-PEREZ, ESPERANZA  (contact)

PROJECT_TERMS: age related;Aging;aging process;aging related;Applications Grants;Area;Award;Awareness;Biology;Biology of Aging;Blood Vessels;Communicable Diseases;Communication;Communities;community center;design;Education;Ensure;Event;experience;Faculty;Faculty Recruitment;Feasibility Studies;Funding;Future;Goals;Grant;hackathon;histone modification;Institution;interest;Knowledge;Leadership;Manuscripts;member;Mentors;Monitor;Musculoskeletal System;next generation;novel;Outcome;Pilot Projects;Preparation;Process;professor;programs;recruit;Research;research and development;Research Design;Research Personnel;Resources;Role;Science;Secure;senior faculty;Services;Shock;skills;stem cell aging;success;United States National Institutes of Health;Writing;Youth


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

PHR: PROJECT NARRATIVE This study will use a novel statistical framework to obtain rates of new cancer cases and cancer deaths at the ZIP-code level, which will allow cancer control researchers and practitioners to focus their efforts on populations at greatest risk. Since the challenges of, and needs for, calculating small area cancer estimates is greatest in rural areas, we will focus on the largely rural states of Iowa, Kentucky, and New Mexico. We will construct user friendly maps and other interactive graphics that can be tailored and included on cancer control/public health websites and develop communication and educational materials to promote the use of these maps for cancer control purposes.

PI_NAMEs: OLESON, JACOB  (contact)

PROGRAM_OFFICER_NAME: CHEN, HUANN-SHENG

PROJECT_TERMS: Age;age group;Area;Atlas of Cancer Mortality in the United States;Bayesian Modeling;Cancer Burden;Cancer Center;Cancer Control;cancer risk;Cessation of life;Code;Collaborations;Communication;Communities;Computer software;County;Data;data visualization;Development;Educational Materials;Ensure;Future;Geographic Locations;Geography;Health;Incidence;Individual;interactive visualization;interest;Intervention;Iowa;Kentucky;Lead;lifestyle factors;Malignant Neoplasms;Maps;Methodology;Methods;Modeling;mortality;Mortality Map;National Cancer Institute;Needs Assessment;neoplasm registry;New Mexico;novel;Online Systems;open source;Outcome;Pattern;Population;Prevention;Privacy;Probability;Public Health;Publishing;Registries;Research;Research Personnel;Resource Allocation;Risk;Risk Adjustment;Risk Estimate;Risk Factors;Rural;rural area;Rural Population;Sample Size;SEER Program;Site;Socioeconomic Factors;Statistical Methods;Statistical Models;surveillance data;Surveys;Time;tool;trend;trustworthiness;Update;user-friendly;Visualization;web site;Work;Writing

PROJECT_TITLE: Development of Small Area Interactive Risk Maps for Cancer Control Efforts


PROJECT_TERMS: Advisory Committees;Advocacy;Aging;Articulation;Biology of Aging;Collaborations;college;Communication;Communities;cost effectiveness;cost efficient;Country;Development;digital;Ensure;Evaluation;Evolution;Fee-for-Service Plans;Fertilization;Fostering;Funding;Geroscience;Heart;Human Biology;improved;Infrastructure;Institution;interest;Joints;Journals;Leadership;Maintenance;man;Medicine;meetings;member;Mentors;Mission;Monitor;multidisciplinary;outreach;Policies;programs;quality assurance;Quality Control;Recommendation;Research;Research Activity;Research Personnel;Research Priority;Research Project Grants;Resources;Scientist;Services;Shock;symposium;Technology;United States National Institutes of Health;Vision;web site


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: CORAL GABLES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Patients with no-option critical limb ischemia (CLI) face to major limb amputations and huge health care costs. We propose to develop novel gene therapy, which employs E-selectin to prime ischemic limb to increase neovascularization and regeneration in ischemic tissues while decreasing tissue damage. It will ultimately eliminate the need for amputation and transform the care for PAD/CLI patients.

PI_NAMEs: LIU, ZHAO-JUN ;VELAZQUEZ, OMAIDA C (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Acceleration;adenoviral mediated;Amputation;angiogenesis;Angiogenic Factor;Angioplasty;Animal Experimentation;Animals;Arteries;artery occlusion;Atherectomy;Atherosclerosis;Biodistribution;Biological;Biological Assay;Blood;Blood capillaries;Blood flow;Blood Tests;Blood Vessels;Bypass;Caring;Cell Adhesion Molecules;Cell Communication;Cell Physiology;Cells;Cellular Morphology;Clinical;Clinical Trials;clinically relevant;critical limb Ischemia;Data;delivery vehicle;Development;Diagnosis;Disease;Docking;Dose;E-Selectin;efficacy validation;endogenous stem cells;Endothelial Cells;endothelial stem cell;experience;Face;Fibrin fragment D;Fibroblast Growth Factor;Foundations;Funding;Future;Gangrene;Gene Delivery;gene delivery system;gene therapy;Generations;Goals;Harvest;healing;Health Care Costs;high risk;Homing;Human;human study;immune cell infiltrate;improved;In Vitro;in vivo;Inflammation;innovation;intercellular communication;Intervention;Ischemia;Isolated limb perfusion;Ligands;limb amputation;limb ischemia;limb loss;Limb Salvage;Limb structure;liver function;Long-Term Effects;manufacture;Mechanics;Medical;Metabolic;Modeling;mortality risk;mouse model;Mus;Muscle Cells;Muscle Fibers;National Heart, Lung, and Blood Institute;Natural regeneration;neovascularization;non-healing wounds;novel;novel therapeutics;Organ;Pain;Pain in lower limb;Paracrine Communication;Pathologic;Patients;Peripheral arterial disease;Phase;Physical Function;Pilot Projects;Plasmids;preclinical study;prevent;Process;progenitor;Protocols documentation;Quality of life;Recovery;recruit;regenerative;regenerative cell;Renal function;repaired;Research;Rest;revascularization;Running;Safety;Salvage Therapy;scale up;Serum;Site;Skeletal Muscle;skin ulcer;stability testing;Stains;stem cells;Stents;Structure;success;systemic toxicity;Testing;Therapeutic;therapeutic angiogenesis;Therapeutic Effect;Thrombosis;tissue regeneration;tissue repair;Tissues;Toxic effect;Transgenes;translational research program;treadmill;treatment optimization;Vascular Endothelial Growth Factors;vector;Viral;Walking;Work

PROJECT_TITLE: Novel Gene Therapy for Critical Limb Ischemia and Limb Salvage in Vascular Occlusive Disease


PI_NAMEs: CUERVO, ANA MARIA (contact)

PROJECT_TERMS: Address;Advisory Committees;Age;age related;age-related disease;Aging;aging mechanism;aging related;Applications Grants;Autophagocytosis;Biochemical;Biological Assay;Biology of Aging;catalyst;Cells;Chemicals;Communication;Communities;Consultations;Cost efficiency;Data;Data Analyses;design;Development;Drug Design;drug development;Educational workshop;Electron Microscopy;Equipment;Experimental Designs;Experimental Models;Fee-for-Service Plans;Funding;Future;gene therapy;hallmarks of aging;hands-on learning;healthspan;Homeostasis;Human;Human Resources;Image;Individual;Inflammation;innovation;Institution;interest;International;Intervention;Invertebrates;Knowledge;learning strategy;Life;Link;Maintenance;Mammals;meetings;member;Metabolism;Methodological Studies;Methodology;Methods;microscopic imaging;Molecular;Molecular Chaperones;Morphology;multicatalytic endopeptidase complex;Natural Compound;novel;operation;Organism;Pathway interactions;Pattern;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Preparation;prevent;Procedures;Process;programs;protein degradation;proteostasis;proteostasis loss;Protocols documentation;Publications;Quality Control;Reagent;Research;Research Personnel;Research Support;Resources;response;Sampling;Services;Shock;Standardization;stem cell function;Stress;System;Techniques;Technology;Testing;therapy design;Tissues;tool;Training;Translations;Treatment Efficacy;Validation;Work


PI_NAMEs: HUFFMAN, DEREK MAJOR (contact)

PROJECT_TERMS: Address;Adipose tissue;Advisory Committees;aged;Aging;Animals;Applications Grants;awake;Behavior;Behavioral;Biological Assay;Biology of Aging;Blood Vessels;Body Composition;Body Temperature;Cannulations;Cardiovascular Physiology;Catheterization;Closure by clamp;Communities;Complex;Consult;Consultations;cost;Data;Data Analyses;Data Collection;design;Development;Drug Design;Drug or chemical Tissue Distribution;energy balance;Energy Metabolism;experience;experimental study;Feeding behaviors;frailty;Funding;Future;Genus Hippocampus;Geropathology;Geroscientist;Glucose;glucose metabolism;Glycogen;Goals;Health;health assessment;healthspan;Hormonal;Human Resources;Hyperglycemia;Hypothalamic structure;imaging modality;in vivo;innovation;insight;Insulin;Intervention;Investments;Laboratories;Leadership;Lipids;Liver;Manuscripts;Measurement;medical specialties;member;Metabolic;metabolic abnormality assessment;metabolic phenotype;Metabolism;metabolomics;Methodology;microCT;Mission;Motor Activity;multiple omics;Mus;Muscle;neuromuscular;new technology;normal aging;novel;Operative Surgical Procedures;Organ;oxidation;Pancreas;Parabiosis;Peripheral;Plasma;pre-clinical;proteostasis;Protocols documentation;Publishing;Rattus;Recovery;Reporting;repository;Research;Research Personnel;Research Support;Resources;Rodent;Rodent Model;Scientist;Services;Shock;Site;Surgeon;surgical service;Technical Expertise;Technology;technology/technique;Tissue Banks;Tissues;Training;Transgenic Mice;translational study;Work


ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: We have found that the growth suppressive effects of noncanonical Wnt signaling by Wnt5a in prostate cancer are mediated through ROR2, and that this Wnt5a/ROR2 signaling is activating the Hippo pathway to suppress YAP1/TAZ activity. We hypothesize this reflects a novel function of ROR2 that is context dependent, and that biomarkers can be identified that will identify the subset of tumors that will be responsive to Wnt5a-mimetic drugs such as Foxy5. The objectives are to determine the precise molecular basis for Wnt5a-mediated activation of the Hippo pathway (Aim 1) and to assess the therapeutic potential of stimulating this pathway, including identification of biomarkers that can predict which tumors may respond to Wnt5a-mimetic drugs (Aim 2).

PI_NAMEs: BALK, STEVEN P. (contact);YUAN, XIN

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Agonist;androgen deprivation therapy;androgen independent prostate cancer;Androgens;antagonist;beta catenin;Binding;Biological Markers;biomarker identification;Cancer Etiology;Carboplatin;Cessation of life;Clinical;Clinical Trials;Complex;CYP17A1 gene;Data;Defect;deprivation;DNA Damage;effective therapy;efficacy evaluation;enzalutamide;Family;Feedback;Generations;GNRH1 gene;Growth;inhibitor;Ligand Binding;Link;link protein;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mediator;men;mimetics;Molecular;Neuroendocrine Prostate Cancer;Neurofibromin 2;novel;Nuclear;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;Physiological;planar cell polarity;Poly(ADP-ribose) Polymerase Inhibitor;predicting response;Prognosis;Prostate;Prostate Cancer therapy;Proteins;receptor;Reporting;Resistance;resistance mechanism;response;restraint;ROR1 gene;Sampling;Signal Pathway;Signal Transduction;Solid Neoplasm;standard of care;taxane;Testing;Therapeutic;transcription factor;tumor;Tumor Promotion;WNT Signaling Pathway

PROJECT_TITLE: WNT5a/ROR2-Mediated Hippo Pathway Activation in Prostate Cancer

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


PI_NAMEs: VIJG, JAN  (contact)

PROJECT_TERMS: Acarbose;Address;Age;age related;Aging;aging related;Animals;Biology;Biology of Aging;Biopsy;Blood specimen;Budgets;Cell Aging;cell preparation;cell repository;Cell Separation;Cells;Centenarian;Clinical Trials;cohort;Collection;Consultations;Core Facility;cost;cost effective;Data;Data Analyses;Data Collection;data resource;Data Set;design;DNA;epigenomics;Exercise;exome;exome sequencing;experience;experimental analysis;experimental study;Fatty acid glycerol esters;follower of religion Jewish;Genetic;Genetic study;genome wide association study;Genomics;Grant;Health Services Accessibility;Homeostasis;Human;improved;Infrastructure;Knowledge;Laboratories;Longevity;member;Metformin;methylomics;Molecular;Multiomic Data;multiple omics;Muscle;Older Population;Pathway Analysis;Peripheral Blood Lymphocyte;Plasma;Process;Proteomics;recruit;repository;Research;Research Design;Research Personnel;Resource Development;Resources;Resveratrol;RNA;Sample Size;Sampling;Services;Shock;single cell genomics;success;Technology;Tissue Sample;transcriptome sequencing;transcriptomics;Translating


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: LA JOLLA

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Atrial fibrillation (AF) is the most common form of arrhythmia in humans, causing unpleasant symptoms, poor quality of life and responsible for ~ 20% of strokes. Available treatments are costly, have serious side effects, long-term toxicities and are not curative. This proposal is to identify novel small molecules that revert AF- associated arrhythmias in human using a novel generation of assays with unprecedented exploratory power and atrial physiology relevance.

PI_NAMEs: COLAS, ALEXANDRE ROMAIN (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Affect;Aging;analog;Animal Model;Anticoagulants;Arrhythmia;Atrial Fibrillation;Attention;Biological;Biological Assay;Biology;Cardiac;Cardiac ablation;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;Catalogs;Cells;Cellular Assay;Cellular biology;Chemicals;cheminformatics;Clinical;cost;Critical Pathways;Data;design;Developing Countries;Disease;Dose;drug discovery;Dryness;electrical property;Electrophysiology (science);Exclusion;experimental study;Future;Generations;Genetic;Goals;Grant;Heart Atrium;Heart Diseases;Heart failure;heart function;heart rhythm;high throughput screening;Human;Image;improved;in vivo evaluation;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;innovation;Kinetics;Lead;liquid chromatography mass spectrometry;mortality;Mutation;Myocardial;novel;novel therapeutics;Outcome;Output;Parents;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Physiology;Powder dose form;Procedures;progenitor;Proliferating;Property;Quality of life;Readiness;Reporting;Research;Resolution;Resources;response;Safety;scaffold;screening;Series;side effect;small molecule;small molecule libraries;statistics;stem cells;Stroke;stroke risk;Structure-Activity Relationship;Symptoms;Systems Analysis;Technology;Testing;Therapeutic;Thromboembolism;Tissues;tool;Toxic effect;trait;Treatment Cost;Validation;Ventricular;Work

PROJECT_TITLE: Discovery of small molecule regulators of atrial cardiomyocyte action potential duration to restore normal cardiac rhythm in atrial fibrillation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Project Narrative We have recently established heterozygous gain-of-function (GOF) mutations in two interferon responsive genes, SAMD9 and SAMD9L (SAMD9/9L) as the major hereditary predisposition to childhood bone marrow failure and myelodysplastic syndromes. The molecular and functional consequences of these mutations on HSC biology and hematopoiesis is not completely understood. The proposed studies will use in vivo murine system and iPSC disease model to delineate the underlying mechanism by which GOF SAMD9L mutations cause hematopoietic defect.

PI_NAMEs: SAHOO, SUSHREE S (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: Accounting;Advisory Committees;Affect;Amino Acids;Anemia;Area;B-Lymphocytes;Biological;Biological Models;Biology;Bone marrow failure;career;Cell Death;cell growth;Cell Physiology;Cells;Child;Childhood;Chromosome Mapping;comparative;Confocal Microscopy;Constitution;CRISPR/Cas technology;Crista ampullaris;cytokine;cytopenia;Defect;Disease;disease model;Dysmyelopoietic Syndromes;Electron Microscopy;Engineering;Engraftment;Ensure;Environment;Erythro;Etiology;Exhibits;Experimental Models;experimental study;Failure;fatty acid oxidation;Foundations;gain of function;gain of function mutation;Gene Expression;Genes;Genotype;Genus Hippocampus;Germ-Line Mutation;Growth;Hematology;Hematopoiesis;Hematopoietic;hematopoietic stem cell differentiation;Hematopoietic stem cells;Heterozygote;Homeostasis;Homing;Human;human induced pluripotent stem cells;Immunology;Impairment;In Vitro;in vivo;induced pluripotent stem cell;Inflammatory;Inherited;insight;Institution;interest;Interferons;Investigation;Knowledge;Link;Lymphopenia;Maps;Marrow;Mediating;Membrane Potentials;Mesenchymal Stem Cells;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Monosomy 7;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myelopoiesis;Natural Immunity;Nature;novel;novel therapeutics;Orthologous Gene;overexpression;Oxidative Phosphorylation;Pathway interactions;Patients;Phase;Phenotype;Physiological;Play;Point Mutation;Positioning Attribute;Predisposition;Proteins;Proteome;Reactive Oxygen Species;Recurrence;Reporter;Research;Resources;Role;segregation;Severities;stem cell biology;stem cell homeostasis;Stress;Structure;Swelling;Syndrome;System;Testing;Toxic effect;transcriptome;Translations;Transmission Electron Microscopy;Up-Regulation;Valine;Virus;Wild Type Mouse;Work

PROJECT_TITLE: Elucidating function of disease-related SAMD9L mutations in hematopoiesis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Although the development of resistance to PARP inhibitors (PARPis) poses a significant clinical challenge for the management of high-grade serous ovarian cancer (HGSOC), the mechanisms underlying the resistance are not fully understood. Our proposed studies aim to explore the role of NAD+ metabolism in the acquired resistance of HGSOC to PARPis. This research will reveal a novel mechanism by which HGSOC acquire resistance to PARPis and will provide important insights into a new therapeutic option for targeting PARPi- resistant HGSOC.

PI_NAMEs: KANAKKANTHARA, ARUN  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Anabolism;Binding;brca gene;BRCA1 gene;BRCA2 gene;cancer cell;Cancer cell line;Cancer Relapse;Cells;Clinical;Clinical Trials;Collaborations;Data;Deacetylase;Deacetylation;Defect;Dependence;design;Development;Disease;Disease Resistance;DNA Repair;effective therapy;efficacy testing;Excision;Gene Expression;Genes;Genetic Transcription;Goals;homologous recombination;homologous recombination deficiency;Hypersensitivity;In complete remission;In Vitro;in vivo;inhibitor;insight;Maintenance Therapy;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Metabolic;Metabolism;Mitochondria;Modeling;mouse model;Mus;mutant;Mutate;Mutation;Nicotinamide-Nucleotide Adenylyltransferase;novel;novel therapeutics;overexpression;Pathway interactions;patient derived xenograft model;Patients;Phase I Clinical Trials;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Pre-Clinical Model;promoter;Proteins;Publishing;Recurrent disease;Regulator Genes;Relapse;Research;Resistance;Resistance development;resistance mechanism;restoration;Role;Serine;Serous;SIRT1 gene;standard care;synergism;Testing;Therapeutic;Translating;tumor;Up-Regulation;Work

PROJECT_TITLE: NAD+ metabolism in PARP inhibitor resistance of ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Rare Diseases;Vector-Borne Diseases;West Nile Virus

PHR: Project Narrative  Viruses that infect the central nervous system can cause long-term brain inflammation and cognitive deficits, but the factors that initiate these responses are unclear. This study will assess the role of neurons that survive viral infection as a source of persistent inflammation.

PI_NAMEs: OBERST, ANDREW ATWELL (contact)

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Address;Apoptosis;Arboviruses;ATAC-seq;Brain;Cell Death;Cell Survival;Cells;Central Nervous System;Cognition;Cognitive;Cognitive deficits;Complex;Death Rate;Defect;Disease;Emerging Technologies;Encephalitis;Enterobacteria phage P1 Cre recombinase;Epigenetic Process;Family;Flaviviridae;Flavivirus;Functional disorder;Gene Expression Profile;Genes;Goals;Hippocampus;Human;Immune response;Immune signaling;Immune system;Impaired cognition;Individual;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Learning;Mediating;Memory;Memory impairment;model organism;Modeling;mosquito-borne;Motor;mouse model;Mus;Neighborhoods;Neuroglia;neuronal survival;Neurons;neurotropic virus;novel;Organism;pathogen;Pathology;Pathway interactions;Patients;Peptide Initiation Factors;postmitotic;preservation;Property;Public Health;Recombinants;Recovery;Research;Resistance;response;Role;Signal Pathway;Signal Transduction;Source;Stimulus;stressor;Suicide;Survivors;System;Techniques;Testing;Tissues;transcriptomics;Viral;viral genomics;Virus;Virus Diseases;West Nile Encephalitis;West Nile viral infection;West Nile virus;Work

PROJECT_TITLE: "Survivor" neurons drive persistent inflammation following West Nile virus infection

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ORG_DEPT: PHYSICS

PHR: Project Narrative: Consistent with its fundamental roles in neurobiology and cell development, complete knockouts of dynein stop the entire MT transport machinery and inhibit mitosis. Mutations that alter the processivity or velocity of cytoplasmic dynein movement lead to pathogenesis of motor neuron degeneration, Alzheimer’s disease, ALS, lissencephaly and schizophrenia, and the absence of axonemal dynein arms causes male infertility and primary ciliary dyskinesia. A detailed investigation of dynein’s mechanochemical cycle and its regulation by dynactin and cargo adaptor proteins will significantly contribute to our understanding of how points mutants in the dynein/dynactin complex contribute to human disease and the development of specific chemical inhibitors of dynein function for the treatment of these diseases in future studies.

PI_NAMEs: YILDIZ, AHMET  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Adaptor Signaling Protein;Alzheimer's Disease;arm;Autophagosome;Behavior;Binding;Binding Sites;biophysical analysis;Cells;Chemicals;Cilia;cilium motility;cofactor;Complex;Cryoelectron Microscopy;Cytoplasm;Development;Disease;dynactin;Dynein ATPase;Exclusion;Exhibits;Future;Generations;Geometry;Goals;human disease;In Vitro;in vivo;inhibitor;Intracellular Transport;Investigation;Kinesin;Knock-out;Lead;Liquid substance;lissencephaly;Male Infertility;Microtubule-Associated Proteins;Microtubules;Mitochondria;Mitosis;Mitosis Inhibition;Modeling;Molecular;molecular imaging;Motility;Motor;motor neuron degeneration;Movement;mutant;Mutation;Neurobiology;Neuropathy;optic trap;optical traps;Pathogenesis;Physiological;Play;predictive modeling;Primary Ciliary Dyskinesias;programs;Recombinants;reconstitution;Regulation;Research;retrograde transport;Role;Schizophrenia;simulation;single molecule;Slide;success;System;tau Proteins;Testing;Tetrahymena;Tubulin;vesicle transport;Work

PROJECT_TITLE: The Mechanism and Regulation of Cytoplasmic and Ciliary Dyneins

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neuroblastoma;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  The neural crest is an important stem-like cell population, known for its migratory behavior, and essential for the normal development of numerous derivatives, such as the craniofacial skeleton, epidermal pigment cells, and much of the peripheral nervous system. Abnormalities in the neural crest contributes to neurocristopathies like familial dysautonomia as well as neural crest-derived cancers (i.e., neuroblastoma, pheochromocytoma, melanoma). Further study of the neural crest and its development will lend insight into this unique population of cells and give further indication of how irregularities in its development can contribute to these health conditions, allowing for the development of targeted treatment.

PI_NAMEs: URRUTIA, HUGO ALEXANDER (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Address;Adhesions;ATAC-seq;Automobile Driving;Behavior;Binding Sites;Cadherins;Candidate Disease Gene;candidate validation;Cell Adhesion Molecules;cell type;Cells;Central Nervous System;Cephalic;Characteristics;craniofacial;Cytoskeletal Modeling;Data Set;Destinations;Development;Dorsal;Ectopic Expression;Elements;Embryo;Enhancers;epithelial to mesenchymal transition;Epithelium;experimental study;Familial Dysautonomia;Fibrosis;Fluorescence-Activated Cell Sorting;Ganglia;gastrulation;Gene Expression;Genes;Genetic Transcription;Genome;genome-wide analysis;Goals;Health;In Situ Hybridization;in vivo;insight;Knowledge;loss of function;Maintenance;Malignant Neoplasms;Mediating;Melanoma;Mesenchymal;migration;Molecular;Neural Crest;Neural Crest Cell;Neural tube;Neuroblastoma;neuromechanism;novel;Peripheral;Peripheral Nervous System;Phase;Pheochromocytoma;Physical condensation;Pigments;Population;Process;Reaction;Regulatory Element;Reporter;Role;Skeleton;somitogenesis;spatiotemporal;stem-like cell;Structure;Structure of trigeminal ganglion;targeted treatment;Tissues;Transcript;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomic profiling;tumor progression;Untranslated RNA;Vertebrates;wound healing

PROJECT_TITLE: Molecular mechanisms driving cessation of neural crest migration and aggregation into cranial ganglia

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE We innovate instrumentation and methodology to develop a novel technology for capturing protein structure at unprecedented depth and speed. Our technology combines techniques from cryogenic electron microscopy (cryo-EM) and mass spectrometry while drawing on concepts from astrophysics to 1) overcome a decades-old methodological bottleneck limiting cryo-EM sample vitrification and 2) maximize the structural insight obtainable by combining the atomic-level detail offered by cryo-EM imaging and the highly resolved measurement of chemical makeup offered by mass spectrometry. These technologies will enable high-throughput proteome- scale structural biology; as such, they will advance our understanding of cellular function and in turn our ability to advance biomedical research.

PI_NAMEs: COON, JOSHUA J (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TITLE: Structure, Function and Regulation of the Proteome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eczema / Atopic Dermatitis;Mental Health;Neurosciences;Pediatric

ORG_DEPT: DERMATOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE Nearly 10 million children in the U.S. live with atopic dermatitis, or eczema, a chronic disease of the skin that causes unbearable itch, disturbances in sleep, and decreased quality of life. Although children with atopic dermatitis are more likely to suffer from learning disabilities, inattention, and poor memory, little is known about the direct and indirect effects of atopic dermatitis on cognition, the mental processes involved in gaining knowledge and problem solving and which can significantly impact long-term health, social, and economic outcomes. In this project, I will characterize the relationship between atopic dermatitis and cognition, identify subgroups of children who may be at greatest risk for cognitive impairment, and determine modifiable risk factors that may be targeted to reduce the negative impact of atopic dermatitis on cognition.

PI_NAMEs: WAN, JOY  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: 16 year old;Address;Affect;Anxiety;Area;associated symptom;Atopic Dermatitis;Attention;Attention deficit hyperactivity disorder;Behavior;Birth;career;career development;Child;Childhood;Chronic;Chronic Disease;Clinic;clinical examination;clinical practice;Cognition;Cognitive;cognitive ability;Cognitive deficits;cognitive development;cognitive function;cognitive performance;cognitive testing;cohort;critical developmental period;critical period;Cross-Sectional Studies;Cutaneous;Data;Data Analyses;Dedications;Dermatologist;Dermatology;Development;Disease;economic outcome;Eczema;Education;emerging adult;Emotions;Enrollment;Environment;Epidemiologist;Epidemiology;Epithelial Cell Aggregation and Separation;executive function;experience;Fatigue;Fellowship;Funding;Future;Goals;Growth;Health;Impaired cognition;Impairment;improved;inattention;Individual;innovation;instrument;Intelligence;Intervention;Knowledge;Learning Disabilities;Life;Longitudinal cohort study;Longitudinal Studies;Measurement;Measures;Mediating;Mediation;Mediator;Medical;Memory;Mental Depression;Mental Processes;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;modifiable risk;Moods;Neurocognition;Neurocognitive;neuroinflammation;Neuropsychology;Occupational;Outcome;Outcome Measure;Pain;Parents;Participant;patient oriented;patient oriented research;Patient Outcomes Assessments;Pediatric Hospitals;Pediatric Research;peer;Pennsylvania;Philadelphia;Positioning Attribute;post-doctoral training;Problem Solving;programs;prospective;Pruritus;Psoriasis;Psychometrics;Quality of life;Questionnaires;Recurrence;Reporting;Research;Research Infrastructure;Research Personnel;Residencies;Resources;Risk;Risk Factors;screening;Services;Severities;skin disorder;Sleep;Sleep disturbances;social;Social outcome;Socioeconomic Factors;socioeconomics;Statistical Methods;Subgroup;Symptoms;systemic inflammatory response;Testing;Time;Training;United Kingdom;United States National Institutes of Health;Universities

PROJECT_TITLE: Impact of Pediatric Atopic Dermatitis on Neurocognitive Function

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Augmented reality (AR) is a rapidly-emerging technology that could provide a novel and exciting treatment strategy for smoking cessation. The goal of this project is to evaluate the efficacy of quitline treatment versus quitline treatment plus an AR smartphone app, while also considering key implementation questions to inform future quitline adoption. If efficacious, the AR app will be ready for dissemination and implementation through quitlines as well as other smoking cessation programs (e.g., in combination with counseling and/or pharmacotherapy), or as a key element of a novel mHealth intervention package.

PI_NAMEs: VINCI, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Abstinence;Accounting;Adjuvant;Adoption;Animals;arm;Augmented Reality;Behavioral;Biochemical;Cellular Phone;Cessation of life;Cigarette;cigarette smoking;Clinic;Clinical;Computer software;conditioning;cost;Cost Analysis;Cost Effectiveness Analysis;Counseling;craving;cue reactivity;Cues;Dependence;design;diaries;digital;Dissemination and Implementation;efficacy evaluation;efficacy testing;Elements;Emerging Technologies;Enrollment;Environment;Evaluation;experimental study;Exposure to;Extinction;Florida;Funding;Future;future implementation;Goals;Grant;Hour;Human;Hybrids;implementation questions;improved;in vivo;incremental cost-effectiveness;indexing;Individual;innovation;interest;Intervention;Interview;Laboratories;Mental Health;mHealth;mhealth interventions;mobile computing;Monitor;Morbidity - disease rate;mortality;Nicotine Dependence;nicotine replacement;novel;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pharmacotherapy;Prediction of Response to Therapy;primary outcome;Procedures;programs;public health priorities;quitline;Randomized;real world application;recruit;remote administration;Research;response;Risk Reduction;satisfaction;Services;sex;smartphone application;Smoke;Smoker;Smoking;smoking abstinence;smoking cessation;Smoking Cessation Intervention;smoking relapse;Smoking Status;standard of care;Stimulus;Substance Use Disorder;Tablets;Technology;Testing;text messaging intervention;therapy development;Tobacco;tobacco abstinence;Tobacco Dependence;tobacco-free;tool;trait;treatment arm;treatment effect;treatment services;treatment strategy;United States;Update;user-friendly;virtual;Work

PROJECT_TITLE: Augmented Reality as an Adjunct to Quitline Counseling for Smoking Cessation

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE New generation pod-style nicotine salt e-cigarettes are popular, however the long-term health consequences of vaping, either independently or in conjunction with smoking, remain unknown. Knowledge gained from this project will provide scientific evidence in support of data-driven regulation of e-cigarette devices under The Family Smoking Prevention and Tobacco Control Act (FSPTCA), specifically concerning the risks of dual combustible and electronic cigarette use.

PI_NAMEs: BELLINI, CHIARA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: abdominal aorta;absorption;Acetylcholine;Adult;aerosolized;Aerosols;Affect;Air;Airway Resistance;American;Animal Model;Animals;Aorta;Apolipoprotein E;Area;Arterial Fatty Streak;base;Biological Availability;Blood;Bronchial Provocation Tests;C57BL/6 Mouse;Cardiopulmonary;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Categories;Cessation of life;Chemicals;Chronic;Cigarette;cigarette smoke;Cigarette Smoker;Clinical;Collagen;combustible cigarette;comorbidity;Cotinine;Data;Deposition;design;Devices;Drug Kinetics;EFRAC;Elastic Fiber;Elasticity;Electronic cigarette;electronic cigarette use;epidemiologic data;Evaluation;experience;experimental study;Exposure to;exposure to cigarette smoke;Family Smoking Prevention and Tobacco Control Act;FDA approved;Generations;Health;Health Care Costs;Heart;Heterogeneity;hypercholesterolemia;Inhalation;interest;irritation;JUUL;Knowledge;Left ventricular structure;Lung;Magnetic Resonance Imaging;Measures;mechanical properties;Mechanics;methacholine;Modeling;mouse model;Mus;Nebulizer;Nicotine;nicotine craving;nicotine vapor;Nose;Outcome;Oxygen;pressure;Property;Proxy;Pulmonary Heart Disease;Regulation;Relaxation;Reporting;Research;Resistance;respiratory;Respiratory System;response;Risk;Risk Factors;Safety;Salts;Shortening Fraction;Smoke;smoke inhalation;Smoker;Smoking;smoking cessation;smoking-related disease;Sodium Chloride;Solvents;Source;Structure;System;Testing;Tissues;Tobacco;tobacco flavor;tobacco products;translational potential;vaping;Virginia;Wild Type Mouse;Workload;Youth

PROJECT_TITLE: Cardiopulmonary outcomes of dual cigarette and e-cigarette use in animal models of chronic exposure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-E(56)R]


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE This new application, which builds on success of a prior undergraduate IMSD program, requests funding to support a Maximizing Access to Research Careers (MARC) T34 at Emory University. We propose to support a diverse cohort of MARC Honors Scholars by building scientific identity and resilience while fostering scientific creativity and embracing research excellence through a structured program as well as an engaged and supportive community. The proposed research training program, which will complement, but not duplicate, requirements for students to complete their degrees will incorporate didactic, research, mentoring, and career development elements to prepare trainees for entry into and completion of research-focused higher degree programs in biological/biomedical fields.

PI_NAMEs: CORBETT, ANITA H. (contact);LIU, ROBERT C;MACBETH, CORA E.;QUAVE, CASSANDRA LEAH

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Admission activity;Attention;Automobile Driving;Bachelor's Degree;Biomedical Research;career;cohort;Communities;Complement;Counseling;Coupled;Data;Dedications;Degree program;Degree requirements;design;Development;Discipline;Doctor of Philosophy;Eligibility Determination;Ensure;Environment;experience;Faculty;graduate student;innovation;Leadership;Learning;meetings;Mentors;next generation;peer coaching;Personal Satisfaction;Program Development;programs;Public Health;Publications;Publishing;recruit;Reproducibility;Research;Research Training;responsible research conduct;role model;Scientist;skills;STEM field;Structure;student training;Students;success;tool;Training;Training Activity;training opportunity;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: MARC at Emory University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]