ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Narrative The proposed research is relevant to public health because understanding the mechanism of neural crest cell fate determination is expected to deepen our understanding of the formation of these cells, informing the etiology of neural crest derived congenital birth defects. Thus, the proposed research is relevant to the part of the NIH mission that pertains to developing a fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: ARTINGER, KRISTIN  (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: Abnormal Cell;Affect;ATAC-seq;Binding;Binding Sites;Biological Models;Biology;bone;candidate identification;Cartilage;Cell Differentiation process;Cell Lineage;cell type;Cells;Cephalic;Chondrocytes;Chromatin;chromatin modification;Chromatin Remodeling Factor;Cleft Lip;cleft lip and palate;Competence;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial structure;Data;Defect;design;Development;Developmental Biology;disability;Disease;DNA;DNA Binding;Embryo;Enhancers;Epigenetic Process;epigenetic regulation;Etiology;EVI1 gene;Exhibits;Family;Foundations;gain of function;GATA1 gene;Gene Expression;Gene Expression Regulation;gene network;gene regulatory network;gene repression;Gene Targeting;Genes;Genetic;Genetic Transcription;Genome;Genomics;Genotype;Goals;Growth;histone methyltransferase;Histones;Human;human disease;Individual;insight;Knock-out;Knowledge;Limes;Link;Mission;Modification;Mus;mutant;Mutation;Nature;Neural Crest;Neural Crest Cell;neuromechanism;novel;Palate;paralogous gene;Pathway interactions;Penetrance;Phenotype;Play;Process;Protein Family;Proteins;Public Health;Regulation;Research;Role;Signal Transduction;Site;Specific qualifier value;stem cell genes;stem cells;Structural Congenital Anomalies;Syndrome;Testing;Therapeutic;Time;Tissues;transcription factor;transcriptome;transcriptome sequencing;United States National Institutes of Health;WNT Signaling Pathway;Zebrafish

PROJECT_TITLE: Genetic and epigenetic regulation of cranial neural crest differentiation


ADMINISTERING_IC: NS

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Huntington's Disease;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Huntington’s disease is a devastating and fatal neurodegenerative disorder for which there is no cure or effective treatment. The combination of emotional, cognitive and motor symptoms, leading to long-term care needs results in an extremely high healthcare cost, estimated at 25 billion dollars a year. This study is aimed at identifying early modifiers of disease with the potential of discovering novel targets for therapeutic intervention prior to disease onset.

PI_NAMEs: WHEELER, VANESSA C (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;adeno-associated virus 9 delivery;Affect;Age;Alleles;Autopsy;behavioral phenotyping;Biochemical;Biological Assay;Biology;Brain;Brain region;CAG repeat;Cell Death;Cell Nucleus;cell type;Cells;Cessation of life;Clinical;Co-Immunoprecipitations;Corpus striatum structure;CRISPR/Cas technology;Cycloheximide;Data;data integration;Disease;Dissection;DNA Mismatch Repair Protein MLH1;DNA Repair Gene;DNA Sequence Alteration;Early identification;effective therapy;emotional symptom;Experimental Genetics;experimental study;Family;Fluorescence-Activated Cell Sorting;Future;gene discovery;Gene Expression;Generations;Genes;Genetic;genetic manipulation;Genetic study;Genetic Transcription;genetic variant;genome wide association study;Genomics;Health Care Costs;Heterozygote;Histologic;Human;human data;Human Genetics;Huntington Disease;Huntington gene;In Vitro;Induced pluripotent stem cell derived neurons;Inherited;insight;Knock-in;Knock-in Mouse;Knock-out;Length;Long-Term Care;lymphoblastoid cell line;Mass Spectrum Analysis;Measures;Mismatch Repair;MLH1 gene;Modeling;Modification;Motion;motor symptom;mouse model;MSH3 gene;Mus;Mutation;nerve stem cell;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;new therapeutic target;next generation;novel therapeutics;Nuclear;Nuclear RNA;Onset of illness;Pathogenesis;Pathology;Pathway interactions;Patients;Pharmacology Study;Phenotype;PMS1 gene;PMS2 gene;prevent;Process;Proteins;Research;Sampling;Sorting;Specificity;System;targeted sequencing;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;Time;Tissues;transcriptome;transcriptome sequencing;transmission process;Ubiquitination;Variant;Western Blotting

PROJECT_TITLE: Huntington's Disease Repeat Instability and Pathogenesis

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: MADISON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative The Center for Demography of Health and Aging at the University of Wisconsin-Madison offers outstanding research training in the demography of health and aging, enriched by several locally-designed large-scale surveys that combine innovative biological and social measurement and provide opportunities for training at multiple forefronts of research on population, aging, and health across the life course. Our trainees receive interdisciplinary training in the social and health sciences and enter research careers in academic institutions and governmental health and statistical agencies. Their research and public service increases the understanding of complex biosocial determinants of health in aging populations and influences national policies that affect the health and well-being of all Americans.

PI_NAMEs: ENGELMAN, MICHAL  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Aging;Life Cycle Stages;Population

PROJECT_TITLE: Population, Life Course and Aging


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Work in my laboratory is focused on understanding how genomic DNA is maintained in eukaryotes and prokaryotes, and on exploring how genome maintenance machines have adopted new roles throughout evolution. Our particular areas of interest are in how chromosomes are organized, recombined, and segregated in eukaryotic meiosis; how viral RNAs are recognized by mammalian innate-immune proteins; and how bacteria have adapted canonical genome maintenance machinery to new defensive roles against viruses and pathogenic DNA molecules. Taken together, our research will provide fundamental knowledge about how organisms maintain and defend their genomes in the face of internal and external threats, and reveal how the molecular machinery underlying genome maintenance has evolved to meet these diverse threats.

PI_NAMEs: CORBETT, KEVIN DANIEL (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Adopted;Architecture;Area;assault;ATP phosphohydrolase;Bacteria;Cell division;Chromosome Structures;Chromosomes;Circular DNA;cohesin;Communities;Complex;condensin;Disease;DNA;DNA Binding;DNA Repair;Educational process of instructing;Eukaryota;Evolution;fascinate;Fellowship;Generations;Genes;Genetic Crossing Over;Genetic Recombination;Genome;genome integrity;Genomic DNA;Germ Cells;Grant Review;Haploidy;Immune;Innate Immune System;interest;Knowledge;Laboratories;Maintenance;Malignant Neoplasms;Meiosis;Messenger RNA;mid-career faculty;Mitosis;Molecular;Molecular Machines;Natural Immunity;Nerve Degeneration;NIH Center for Scientific Review;novel;Nucleic Acids;Organism;Pathogenicity;Plasmids;programs;Prokaryotic Cells;Proteins;recruit;Research;RNA;RNA-Binding Proteins;Role;Science;segregation;Sexual Reproduction;Signaling Protein;Structural Biologist;Structure;System;Translations;United States National Institutes of Health;viral RNA;Virus;Work

PROJECT_TITLE: Molecular mechanisms of nucleic acid recognition and maintenance in meiosis and innate immunity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Hematology;Infectious Diseases;Neurodegenerative;Patient Safety;Sepsis

ORG_CITY: PROVIDENCE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it would provide crucial information to inform the design of programs implemented by the Centers for Medicare and Medicare Services to improve care for patients with sepsis and Alzheimer’s disease and related dementias (ADRD). Given Medicare’s critical importance for patients with sepsis and ADRD, along with the national implementation of the bundled payment, even minor improvements to bundled payment has the potential to improve the health of thousands of older Americans.

PI_NAMEs: RYAN, ANDREW M (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acute;acute care;Address;Admission activity;adverse outcome;Algorithms;Alzheimer's disease patient;Alzheimer's disease related dementia;American;beneficiary;bundled payment;Caring;Cessation of life;Characteristics;Clinical;clinical care;clinical risk;Clinical Treatment;Code;Coupled;Data;data registry;Data Sources;design;Diagnosis;econometrics;functional loss;Health;Home;hospice environment;hospital readmission;Hospitalization;Hospitals;Immune system;Impaired cognition;improved;Incentives;Infection;innovation;Inpatients;insight;Link;Managed Care;Medical;Medicare;Medicare claim;Methods;Michigan;Minor;Morbidity - disease rate;mortality;novel;older patient;Outcome;Pathway interactions;Patient Care;Patient Discharge;Patient risk;Patient-Focused Outcomes;Patients;Pattern;Policies;programs;Public Health;Reaction;Research;Risk Factors;Sepsis;septic patients;Services;Testing;Time;Treatment Cost;Treatment outcome;treatment pattern;Variant;Voluntary Programs;Vulnerable Populations

PROJECT_TITLE: The Impact of the Bundled Payment for Care Improvement Advanced on Outcomes for Patients with Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


NIH_SPENDING_CATS: Cancer;Skin Cancer

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The morphogen netrin promotes neuronal development and cancer progression, yet we know little about how cells interpret netrin into shape changes. Our work exploits developing neurons and migrating melanoma cells as model systems to examine how netrin alters cellular shape during development and metastasis. This supplement seeks support to promote diversity under the parent award.

PI_NAMEs: GUPTON, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Actins;active control;Address;Biochemical;Biological Models;Cell membrane;cell motility;Cell Shape;cell type;Cells;Cellular Structures;Characteristics;Computer Vision Systems;Cues;Cytoskeletal Proteins;Cytoskeleton;Data;depolymerization;Development;Disparate;Environment;Event;Exocytosis;extracellular;Filopodia;Frequencies;Genetic;genetic regulatory protein;Goals;Health;Knowledge;Lead;Machine Learning;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Membrane;Microfluidics;Microscopy;Microtubules;migration;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;morphogens;Motility;Neoplasm Metastasis;neural network;neuron development;Neuronal Plasticity;Neurons;novel;parent project;Pathogenesis;Pathologic;Pathology;Peripheral;Phenotype;Phosphotransferases;Physiology;Play;polymerization;Polymers;Program Description;programs;protein transport;Proteins;Publishing;Quantitative Evaluations;Regulation;Research;response;Role;sensor;Shapes;spatiotemporal;System;Testing;tool;trafficking;TRIM Gene;tumor progression;ubiquitin-protein ligase;Ubiquitination;Vesicle;Work

PROJECT_TITLE: Coordinated Cytoskeletal Dynamics and Membrane Remodeling in Cellular Shape Change

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: TUCSON

ORG_NAME: CRITICAL PATH INSTITUTE

ORG_STATE: AZ

PHR: NARRATIVE Irritable bowel syndrome (IBS), which impacts approximately 10% to 15% of adults in the United States, is a chronic, oftentimes disabling gastrointestinal (GI) disorder characterized by recurrent abdominal pain associated with alterations in bowel habits (diarrhea and/or constipation). The need for better endpoint measures in IBS drug development that would enable a more comprehensive and detailed assessment of abdominal and bowel-movement- related symptom severity for its main subtypes—IBS with predominant diarrhea (IBS-D), IBS with predominant constipation (IBS-C), and alternating or mixed IBS (IBS-M)—has been clearly identified. To address this unmet measurement need, the overall objective of this project is to develop a Full Qualification Package to support the qualification of the Diary for Irritable Bowel Syndrome Symptoms–Diarrhea (DIBSS-D) with the resulting impact being the advancement of a publicly available, psychometrically sound, fit-for-purpose patient-reported outcome measure that will facilitate the assessment of clinical benefit in IBS-D treatment trials.

PI_NAMEs: EREMENCO, SONYA  (contact)

PROGRAM_OFFICER_NAME: TOMITA, YORK

PROJECT_TITLE: Preparation and Submission Support of a Full Qualification Package (FQP) for the Diary for Irritable Bowel Syndrome Symptoms—Diarrhea (DIBSS-D) (DDT #000148)

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-S (12)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE The cause of multiple system atrophy (MSA), a fatally progressive adult-onset neurodegenerative disease, is the abnormal accumulation of the protein alpha-synuclein, a mechanism that can be targeted by drug therapy. This trial readiness proposal addresses current critical obstacles for clinical trials of MSA by validating novel tools that accurately measure patient’s worsening, including clinical scales, neuroimaging and biochemical measures of disease progression. The timing is excellent, with therapeutic targets for MSA already identified, exceptional network of collaboration among researchers, pharmaceutical industry, and patient advocacy groups, and several drugs in the pipeline ready for clinical testing within the next five years.

PI_NAMEs: KAUFMANN, HORACIO  (contact)

PROGRAM_OFFICER_NAME: GARCIA, LINA FERNANDA

PROJECT_TERMS: Acceleration;Address;Adult;Advisory Committees;Advocacy;alpha synuclein;Biochemical;Biological;Biological Markers;Clinical;clinical outcome assessment;clinical outcome measures;Clinical Research;clinical trial readiness;Clinical Trials;Cohort Studies;Collaborations;Controlled Clinical Trials;Data;Disease;Disease Progression;drug candidate;drug development;Drug Industry;Enrollment;European;follow-up;Image;Industry;Infrastructure;International;Measures;Multiple System Atrophy;Natural History;Neurodegenerative Disorders;neuroimaging;novel;Observational Study;Outcome Measure;patient advocacy group;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Placebo Control;prospective;Proteins;Rare Diseases;Research;research clinical testing;Research Personnel;response;Role;Site;Study Subject;synucleinopathy;targeted treatment;Testing;therapeutic target;tool;trial readiness;United States National Institutes of Health

PROJECT_TITLE: Clinical Trial Readiness for Multiple System Atrophy


ADMINISTERING_IC: CE

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative To realize the goals of the federal Overdose Prevention Plan, it is necessary to identify strategies to address the impact of polydrug use and the multiple intersecting determinants of PDU and overdose mortality over time. The proposed research will address CDC primary objectives to inform overdose prevention through in-depth understanding of PDU combinations and trajectories most likely to result in overdose. This interdisciplinary project will provide a foundation for applied intervention approaches that build on a rich understanding PDU patterns, trajectories, and life course risk and protective factors.

PI_NAMEs: GENBERG, BECKY LYNN;GERMAN, DANIELLE  (contact)

PROJECT_TITLE: RFA-CE-22-011: Mixed methods study of polysubstance use to optimize overdose prevention


ORG_CITY: SEATTLE

ORG_NAME: SEATTLE-KING COUNTY PUBLIC HEALTH DEPT

ORG_STATE: WA

PHR: We propose to conduct an exploratory sequential mixed methods evaluation of drug use behaviors, patterns, trajectories, and risk factors in a sample of King County, WA residents who initiated use within the past three years of a high-risk drug class. The quantitative and qualitative results from our study will inform development of novel early intervention strategies and development of methods to reach a currently hidden population with overdose prevention programs and related evaluations.

PI_NAMEs: HOOD, JULIA ELIZABETH (contact)

PROJECT_TITLE: RFA-CE-22-011 -Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose - 2022


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Hydrocephalus;Neurosciences;Pediatric;Rare Diseases

PHR: PROJECT NARRATIVE Hydrocephalus affects 1/1,000 live births and is a major cause of morbidity and mortality. We propose to use a functional genomics approach that combines next-generation DNA sequencing and a high-throughout functional screening platform to discover, validate, and gain mechanistic insight into novel gene mutations associated with human congenital hydrocephalus. Results could lead to fundamental new insights into human brain development and serve as the basis for improved clinical decision-making, prognostication, and novel biology-based treatments for congenital hydrocephalus patients.

PI_NAMEs: DENIZ, ENGIN ;JIN, SHENG CHIH ;KAHLE, KRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Acceleration;Accounting;Affect;autism spectrum disorder;bioinformatics pipeline;Biological;Biological Models;Biology;Birth;Brain;Brain Diseases;Candidate Disease Gene;case control;Case Study;Cerebral Ventricles;Cerebrospinal Fluid;Cilia;Clinical;clinical decision-making;Clinical Management;cohort;Communication;Congenital Hydrocephalus;Copy Number Polymorphism;cost effective;Coupling;CRISPR/Cas technology;Data;de novo mutation;Development;Diagnostic;Differentiation and Growth;Disease;DNA Resequencing;DNA sequencing;Embryo;Etiology;Evaluation;exome sequencing;experience;Family;Fluid Balance;Frequencies;functional genomics;Future;gene discovery;Gene Expression;Gene Mutation;Genes;Genetic;genetic approach;genetic architecture;Genetic Counseling;genetic pedigree;Genetic Predisposition to Disease;Genomic approach;Heterogeneity;Homologous Gene;Human;human fetal brain;Human Genetics;Hydrocephalus;Immunohistochemistry;Impairment;improved;in silico;In Situ Hybridization;in vivo;insight;International;knock-down;Knowledge;Live Birth;Measures;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;Nature;nerve stem cell;Neural Cell Adhesion Molecule L1;Neural Tube Development;Neurodevelopmental Disorder;neurogenesis;Neurons;next generation;novel;novel diagnostics;novel therapeutics;Nucleotides;Ontology;Operative Surgical Procedures;Optical Coherence Tomography;overexpression;Parents;particle;Pathogenesis;Pathway interactions;Patients;Pattern;Phenotype;postnatal;Preventive;proband;prognostication;Rana;recruit;Research;screening;segregation;SMARCC1 gene;Social support;Stem Cell Development;stem cell fate;stem cell growth;targeted sequencing;Testing;Therapeutic;Time;tool;Transgenic Organisms;transmission process;Validation;Variant;ventricular system;Work;Xenopus

PROJECT_TITLE: Human Genetics and Molecular Mechanisms of Congenital Hydrocephalus

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: Results from recent TCGA and pathological studies imply the oncogenic role for KLF4 in breast carcinogenesis, although the underlying molecular mechanisms by which dysregulation of KLF4 contributes to breast tumor initiation, progression and metastasis remain unknown. This proposal will determine the impact of interplay between KLF4 and PARP1 in breast tumor progression and metastasis, and further develop a small molecule inhibitor of KLF4 that synergizes with PARP inhibitors for anti-breast cancer treatment, especially for triple negative type breast cancers. Completion of this project will uncover the mitogenic role of KLF4 in breast cancer development, and could provide a new strategy for breast cancer therapy by synergism PARP1 and KLF4.

PI_NAMEs: WAN, YONG  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: 3-Dimensional;ADP ribosylation;Affect;Apoptosis;BRCA1 gene;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer therapy;Breast Cancer Treatment;Breast Carcinogenesis;carcinogenesis;Cell division;Cells;Chromatin;clinically relevant;Computer Models;Cryoelectron Microscopy;Data;Development;DNA Damage;DNA damage checkpoint;DNA Repair;drug sensitivity;Endocrine;ERBB2 gene;Exhibits;Generations;Genetic Transcription;genome integrity;Genome Stability;Genomic Instability;GKLF protein;Goals;Human;Immunohistochemistry;Impairment;in vivo;inhibitor;Knock-in;Maintenance;Malignant - descriptor;Malignant Breast Neoplasm;Mammary Neoplasms;Mammary Tumorigenesis;Mediating;Modeling;Molecular;Neoplasm Metastasis;novel;novel strategies;Oncogenic;Organoids;Pathologic;patient derived xenograft model;Physiological;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Post-Translational Protein Processing;Prognosis;protein complex;recruit;response;RNA Interference;Role;Signal Transduction;small molecule inhibitor;Structure;synergism;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic Intervention;Transcriptional Regulation;triple-negative invasive breast carcinoma;tumor initiation;tumor progression;Tumor Promotion;tumorigenesis;Work

PROJECT_TITLE: Targeting Posttranslational Modifications in Breast Carcinogenesis

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: A disturbing number of Veterans suffer from cognitive dysfunction due to dementia that has a high likelihood of progressing into Alzheimer's disease. Neurodegeneration is a complex process, involving synaptic dysfunction and memory loss. We aim to examine the signaling molecule Brain-Derived Neurotrophic Factor (BDNF), considered particularly important for neural health and synaptic plasticity in the context of Alzheimer's disease, by assessing its role in magnetic brain stimulation. Transcranial magnetic brain stimulation has been shown to increase BDNF and thus potentially improve cognitive performance in dementia. Information gained from this proposal will enhance our knowledge of both cognitive decline and treatment options. Given that Veterans with cognitive impairment create a huge burden on themselves and others, it is critical to focus research on this eff ort.

PI_NAMEs: MCNERNEY, MARGARET WINDY (contact)

PROJECT_TERMS: 3xTg-AD mouse;abeta accumulation;Acute;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Animal Model;Animals;Biochemical;Biochemistry;Biological Markers;biomarker evaluation;Blood specimen;Brain;Brain Diseases;Brain Pathology;Brain region;Brain-Derived Neurotrophic Factor;Caregivers;Caring;cell cortex;Cephalic;Cerebrospinal Fluid;Chronic;clinical translation;Cognition;Cognitive;cognitive function;cognitive performance;cognitive rehabilitation;Cognitive Therapy;cohort;comparison control;Complex;Dementia;Disease;effective therapy;Electromagnetics;experimental study;Failure;Functional disorder;Funding Opportunities;Future;Health;Human;human model;hyperphosphorylated tau;Impaired cognition;Impairment;improved;Individual;innovation;insight;Intervention;Knowledge;Link;locus ceruleus structure;Magnetism;Measurement;Measures;Mediating;Medical;Memory;Memory Loss;Mentors;mild cognitive impairment;military veteran;Molecular;mouse model;Mus;Nerve Degeneration;neural;neurochemistry;Neurodegenerative Disorders;Neuronal Plasticity;neurotrophic factor;novel therapeutic intervention;Pathology;Patients;Performance;Peripheral;Phosphotransferases;Plasma;pre-clinical;prevent;Process;Production;Proteins;receptor;Receptor Signaling;Rehabilitation therapy;repetitive transcranial magnetic stimulation;Research;Resources;Role;Senile Plaques;Signal Pathway;Signal Transduction;Signaling Molecule;Structure;Synapses;Synaptic plasticity;System;technology development;Test Result;Testing;Transgenic Mice;Translating;Treatment outcome;treatment strategy;Tropomyosin;United States Department of Veterans Affairs;Urine;Veterans;Vietnam;Work

PROJECT_TITLE: BDNF-mediated effects of rTMS on cognitive dysfunction in Veterans

STUDY_SECTION: NURD

STUDY_SECTION_NAME: Neurobiology D[NURD]


PHR: PROJECT NARRATIVE Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are a genetic defects of heme biosynthesis that cause life-long, painful cutaneous sensitivity to light. The objective of this study is to determine the efficacy and safety of oral cimetidine administration for treatment of the protoporphyrias. Efficacy will be based on protoporphyrin levels, photosensitivity, and quality of life questionnaires.

PI_NAMEs: ANDERSON, KARL ELMO;DICKEY, AMY KATHRYN (contact)

PROGRAM_OFFICER_NAME: KARP, JACQUELINE

PROJECT_TITLE: Effect of Oral Cimetidine in the Protoporphyrias (IND 153247 submitted 9/2/2020)


ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative Trauma is the leading cause of death in people from 1-44 years and the leading cause of life years lost. The proposed renewal T32 program will provide support for postgraduate research training in injury and critical illness in the Department of Surgery at McGovern Medical School at The University of Texas Health Science Center at Houston. The goal of this training program is to provide a cohort of future clinical and translational scientists to increase basic and clinical understanding of trauma-related illness and improve the outcomes of injured patients.

PI_NAMEs: COX, CHARLES S (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TITLE: Postdoctoral Training Program in Trauma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE The US Preventative Services Task Force (USPSTF) concluded that current evidence is insufficient to assess the balance of benefits vs harms of screening for mild cognitive impairment (MCI) and early Alzheimer's disease and related disorders (ADRD). The overarching GOAL of the current proposed investigation is to build upon our previous work and to further address the major challenges to improve the detection of MCI and early ADRD. Our long-term goal is to increase “real world” early MCI and ADRD detection, diagnosis, and treatment; address USPSTF Key Questions; and reduce disparities in health outcomes. This resonates strongly with the three guiding principles of the National Alzheimer's Project Act (NAPA), especially its third principle: “Transform the way we approach Alzheimer's disease and related dementias.”

PI_NAMEs: GALVIN, JAMES E (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Address;Adult;Advance Care Planning;Advocate;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid;Biological;Biological Markers;Blue Cross;Brain;Caregivers;Caring;Clinical Research;Cognition;Cognitive;cognitive performance;cohort;Communities;comorbidity;Confusion;Data;Data Analyses;Decision Making;Dementia;Detection;detection method;Diagnosis;disparity reduction;Eligibility Determination;Enrollment;Equilibrium;Ethnic Origin;Evaluation;Family;Florida;Foundations;Funding;Genetic;Goals;Gold;health care service utilization;health disparity;health related quality of life;imaging biomarker;Impaired cognition;Impairment;improved;Individual;innovation;instrument;Insurance;interest;Intervention;Investigation;Link;Liquid substance;Longitudinal cohort;Magnetic Resonance Imaging;Measures;Medical;Memory;Methods;mild cognitive impairment;Mind;Monitor;Moods;multiple data types;National Institute on Alcohol Abuse and Alcoholism;Nerve Degeneration;novel;Outcome;Outcome Measure;Participant;Pathology;patient oriented;Patients;Persons;Pharmaceutical Preparations;Phenotype;Plasma;population based;Population Heterogeneity;Positron-Emission Tomography;Preparation;Prevalence;primary outcome;Progress Reports;Protocols documentation;public health relevance;Publishing;Race;recruit;Research;response;Risk;Sampling;screening;Services;sex;sociodemographic variables;Staging;System;tau Proteins;Testing;Time;tool;United States Preventative Services Task Force;Update;Validation;Visit;Work

PROJECT_TITLE: Multicultural Community Dementia Screening

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Technology has become available that allows for medication usage tracking for adolescents with asthma, who are at high risk for medication non-adherence. This project seeks to evaluate medication usage patterns in adolescents with asthma, utilize in-depth interview techniques to understand how to improve medication use and create interventions tailored to each individual. We will then test these interventions to see how feasible they are for implementation in the clinical setting.

PI_NAMEs: DE KEYSER, HEATHER  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Adherence;adherence rate;Adolescent;Adrenal Cortex Hormones;Adult;Agonist;Asthma;asthma exacerbation;asthmatic;Award;Behavior;behavior change;Behavioral;Biological;care outcomes;career;Caring;Child;Childhood;Childhood Asthma;Chronic Disease;Clinical;Clinical Trials;Colorado;cost;Cost Savings;Data;Data Collection;Disease;Electronics;Evaluation;Expenditure;Feeling;Funding;Future;Goals;Health;Health behavior change;health care service utilization;Health Services Research;Health Status;Healthcare;high risk;Hospitalization;improved;Individual;Inhalation;innovation;Institution;International;Intervention;Interview;Measurement;Measures;Medical;medical schools;medication compliance;medication nonadherence;Mentors;Mentorship;Methods;Monitor;monitoring device;Morbidity - disease rate;Outcome;Outcomes Research;outreach;Patient Compliance;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Pediatric Hospitals;personalized intervention;personalized medicine;Pharmaceutical Preparations;Phenotype;Pilot Projects;pilot test;Population;Positioning Attribute;pragmatic trial;Provider;Public Health;Qualitative Methods;Qualitative Research;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Refractory;Research;Research Infrastructure;Research Methodology;Research Personnel;research study;Science;Self Determination;sensor technology;side effect;skills;System;Techniques;Technology;Testing;theories;therapy design;Time;Training;treatment risk;Universities;Work

PROJECT_TITLE: Treatment Phenotypes for Adolescents with Asthma

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: This proposal outlines investigations of how ATP signaling in macrophages promotes inﬂammatory states that originate at a cellular level. These studies are directly relevant to human disease, since inﬂammatory responses underlie physiological, protective mechanisms, but also diseases including cancer, and cardiac dysfunction. Successful completion of these studies will provide new computational tools and insights into macrophage physiology and pathophysiology of immune responses.

PI_NAMEs: KEKENES-HUSKEY, PETER MICHAEL (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acceleration;Adenosine Triphosphate;Attenuated;Automobile Driving;Award;Calcium Signaling;Calmodulin;cell behavior;Cells;Chronic;Computer Models;computerized tools;Coupling;cytokine;Disease;ecto-nucleotidase;Elements;Eukaryotic Cell;Functional disorder;Goals;Grant;healing;human disease;Immune;immune function;Immune response;Immune system;Inflammation;Inflammatory;Inflammatory Response;insight;Investigation;Leukocytes;Macrophage;Malignant Neoplasms;Mediating;migration;Modeling;multi-scale modeling;Myocardial dysfunction;Nucleotides;Outcome;oxidation;P2X-receptor;pathogen;Pathway interactions;Phagocytosis;Physiological;Physiology;Positioning Attribute;Post-Translational Protein Processing;Process;Proteins;Reactive Oxygen Species;receptor;Research;Rest;Role;sensor;Sepsis;Signal Induction;Signal Pathway;Signal Transduction;simulation;stem;System;Tissues;tool;Up-Regulation

PROJECT_TITLE: Probing macrophage cell nucleotide sensing and calcium signaling through computation

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioids;Pain Research;Substance Misuse

PHR: Project Narrative Opioids are powerful analgesics, but their harmful side effects have led to a nationwide opioid epidemic. Neurons in the periaqueductal gray (PAG) contribute to the pain-relieving and rewarding effects of opioids, but the organization of these circuits and how they contribute to opioid-induced behaviors remains unclear. To elucidate how opioids affect PAG neurons, I will characterize the organization of PAG neural circuits and investigate how they contribute to opioid-induced behaviors using input-output circuit mapping, single-cell transcriptomics, and circuit-specific neuromodulation experiments in freely moving animals.

PI_NAMEs: NIEHAUS, JESSE  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;abuse liability;addiction;Affect;Affective;American;Amygdaloid structure;Analgesics;Animals;antagonist;Architecture;Area;Automobile Driving;Behavior;Behavioral;Behavioral Assay;Bioinformatics;Biological Assay;Brain;cell type;Cells;chronic pain;Classification;Communities;Complement;Complex;conditioned place preference;Data;Electric Stimulation;Emotions;Euphoria;experience;experimental study;Fright;G-Protein-Coupled Receptors;Genes;Genetic;Genetic Markers;Genetic Transcription;Goals;Heterogeneity;Intractable Pain;Label;learned behavior;Location;loss of function;Maps;Measures;Mentorship;midbrain central gray substance;Midbrain structure;Molecular;Molecular Biology;Molecular Conformation;Morphine;morphine administration;Motivation;mouse genetics;mu opioid receptors;Mus;Nervous System;neural circuit;Neuroanatomy;Neurons;neuroregulation;Neurosciences;Nociception;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid use;Outcome;Output;Pain;Pain management;pain relief;Patients;Pattern;Physical Dependence;prescription opioid;presynaptic;Property;Research;Research Personnel;Resources;Rewards;Rodent;Sensory;side effect;single-cell RNA sequencing;Spatial Distribution;Speed;Structure;Testing;Training;transcriptomics;Ventilatory Depression;Ventral Tegmental Area;Work

PROJECT_TITLE: Characterizing the connectivity and molecular composition of opioid-sensitive neurons in the periaqueductal gray


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: FULLERTON

ORG_DEPT: BIOLOGY

ORG_NAME: CALIFORNIA STATE UNIVERSITY FULLERTON

PHR: PROJECT NARRATIVE The research described in this proposal focuses on understanding how HSPA1A localizes at the cell surface and outside of stressed and cancer cells. The characterization of this mechanism will allow devising of new ways to render these cells sensitive to conventional therapies and activate the immune system against them.

PI_NAMEs: NIKOLAIDIS, NIKOLAS  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Affect;Binding;Biochemistry;Biosensor;Cancer Biology;cancer cell;carcinogenesis;career;Cell Fractionation;Cell membrane;Cell secretion;Cell surface;Cell Survival;Cells;Cellular Stress;conventional therapy;differential expression;Distant Metastasis;endosome membrane;Endosomes;exosome;experimental study;extracellular;Extracellular Protein;Future;Gene Silencing;Generations;Genes;Goals;Heat shock proteins;Heat-Shock Response;Homeostasis;Image;Immune response;Immune system;immunoregulation;Immunosuppression;inhibitor;Intervention;Knowledge;Lipid Binding;lipidomics;Lipids;Literature;Location;Lysosomes;Malignant Neoplasms;Measures;Mediating;Membrane;Membrane Lipids;Membrane Microdomains;Modification;Molecular Chaperones;Mutagenesis;neoplastic cell;novel therapeutics;palmitoylation;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;phosphatidylinositol 3-phosphate;phosphatidylinositol 4-phosphate;Phosphatidylinositols;Phosphatidylserines;Phosphorylation;Play;Post-Translational Modification Alteration;Post-Translational Protein Processing;Protein Secretion;Proteins;Proteomics;Radiation;Radiation therapy;radioresistant;recruit;Research;Role;Science;Stress;Students;Testing;trafficking;Training;tumor;undergraduate student;Vesicle

PROJECT_TITLE: Interaction between HspA1A, a seventy-kDa heat shock protein, and lipids in stressed cells


NIH_SPENDING_CATS: Atherosclerosis;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Chronic total occlusions (CTOs) are lesions comprised of hard fibro-calcific material that completely stop blood flow in a coronary artery and are traditionally treated with either medical therapy or bypass surgery. Percutaneous Coronary Interventional (PCI) procedures can be performed, but are technically difficult, and often pass the CTO by traversing inside the vessel wall, leading to higher complication rates. We are developing and testing an optoacoustic- ultrasound image-guided cold-laser-wire which can provide any interventional cardiologist a much simplified single-operator approach to stay true-lumen while traversing a coronary CTO and reducing rate of patient complications.

PI_NAMEs: FELDMAN, MARC DAVID;MILNER, THOMAS E (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Acute;Address;Adipose tissue;Affect;American;Angiography;Animal Model;Anterior Descending Coronary Artery;Arterial Fatty Streak;Arteries;Atherosclerosis;Blood flow;Bypass;calcification;California;Cardiac;Cardiac Surgery procedures;Cardiac Tamponade;Cardiology;Cardiovascular Diseases;Catheters;cell injury;Cessation of life;Chest Pain;Chronic;Clinic;Complex;Complication;Coronary;Coronary artery;Coronary Artery Bypass;cost;design;Development;Devices;Diameter;Discipline;Disease;Dissection;Elderly;Endothelial Cells;Environment;Event;Failure;Family suidae;Fatigue;Fiber;Goals;Health;Heart Transplantation;Hour;Human;Image;image guided;imaging system;improved;in vivo;Injury;innovation;Intervention;Lasers;Left;Left Ventricular Ejection Fraction;Length of Stay;Lesion;Light;Mechanics;Medical;minimally invasive;Morbidity - disease rate;mortality;Myocardial Infarction;novel;Operative Surgical Procedures;optical fiber;Optics;Organ Transplantation;Outcome;Participant;Patient-Focused Outcomes;Patients;percutaneous coronary intervention;Perforation;Peripheral;photoacoustic imaging;pressure;Procedures;Program Development;randomized, controlled study;real-time images;Recovery;reduce symptoms;Research;research and development;restenosis;revascularization;safe patient;Shortness of Breath;Side;sound;stent thrombosis;Stents;Structure of left gastric vein;Symptoms;System;Techniques;Testing;Therapeutic;Time;Treatment Protocols;Ultrasonography;ultrasound;Universities;Veins;Venous

PROJECT_TITLE: Transvenous Optoacoustic-Ultrasound Guided Cold Laser Wire for Crossing Coronary Chronic Total Occlusion

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Lung;Nanotechnology

ORG_CITY: DURANGO

ORG_NAME: FORT LEWIS COLLEGE

PHR: Project Narrative The goal of this project is to create a novel microfluidic lung-on-a-chip device that utilizes the unique properties of porous silicon and leverages precision biomaterials and biomanufacturing techniques to better mimic the structural composition of the lung in vitro. The proposed research is relevant to public health because the development of a fully organic lung-on-a-chip device will have positive translational outcomes in the prevention and treatment of a wide range of inflammatory and fibrotic pulmonary diseases.

PI_NAMEs: BLAKE, DAVID JAMES (contact)

PROJECT_TERMS: Address;Alveolar;Anatomy;Animal Model;Animals;Apoptosis;Architecture;Atomic Force Microscopy;Basic Science;Biochemical;Biocompatible Materials;Biodegradation;Biological Models;Biomanufacturing;biomaterial compatibility;Biomedical Engineering;Body System;candidate identification;Cell Culture Techniques;Cell secretion;cell type;Cells;Characteristics;cigarette smoke;Coculture Techniques;Collagen;Complex;Cues;cytokine;Data;design;Development;Devices;Disease;Disease Progression;drug candidate;Elastin;Endothelial Cells;Epithelial Cells;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Extravasation;fabrication;fibrotic lung disease;flexibility;Flow Cytometry;Functional disorder;Future;Goals;Growth Factor;Human;Human Characteristics;human disease;human model;Hypoxia;Immune;Immunofluorescence Microscopy;immunoregulation;In Vitro;in vitro Model;in vivo;Inflammatory;innovation;insight;Isodicentric Chromosome;Knowledge;Lead;Lipopolysaccharides;live cell imaging;Lung;Lung Diseases;Macrophage;materials science;Mediator;Membrane;Microfluidic Microchips;Microfluidics;Modeling;nanomaterials;novel;Organ;organ on a chip;Outcome;Pathogenesis;pathogenic microbe;Pathway interactions;Peptide Hydrolases;Pharmacologic Substance;Physiology;Porosity;pre-clinical;Prevention;Production;Property;prospective;Public Health;Pulmonary Hypertension;Reproducibility;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;Safety;Scanning Electron Microscopy;Silicon;Structure;success;Surface;Techniques;Therapeutic;Thinness;three dimensional structure;toxicant;Translating;translational impact;translational therapeutics;Xenobiotics

PROJECT_TITLE: Utilizing biodegradable porous silicon membranes as a novel design for lung-on-a-chip microfluidic devices to investigate extracellular matrix interactions.


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Heart Disease;Mental Health;Neurosciences;Prevention;Sleep Research

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: NARRATIVE Insufficient sleep is a major global public health concern that places people at increased risk for negative health, including cardiovascular disease; unfortunately, many individuals and occupations at heightened risk for sleep disturbance, like firefighters, are limited in their ability to identify and access evidence-based intervention. This project aims to increase access to sleep health intervention by testing and implementing an evidence-based sleep health coaching program within the fire service. The results of this study will identify factors that are key in the adoption of sleep health intervention to inform the implementation and dissemination of sleep health workplace wellness programs nationally.

PI_NAMEs: HAYNES, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Acceleration;Achievement;actigraphy;Address;Adoption;Affect;Arizona;Awareness;base;Behavioral;behavioral health;behavioral sleep intervention;Behaviorism;Blood Pressure;Body mass index;burnout;Cardiac;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;care seeking;career;Cause of Death;Cessation of life;Cholesterol;Clinic;Clinical;Clinical effectiveness;clinical implementation;Clinical Trials;cluster randomized design;Cognitive;Cognitive Therapy;Communities;comparative;Data;Dimensions;Disease Outcome;Dissemination and Implementation;Education;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation trial;Enrollment;Evaluation;Event;evidence base;Evidence based intervention;experience;Fatigue;Fire - disasters;fire fighter;first responder;formative assessment;Foundations;Future;future implementation;Goals;Health;Health behavior;Health behavior change;health care settings;Health Hazards;Health Promotion;Health Services;Healthcare;Heart Rate;help-seeking behavior;high risk population;Hour;hybrid type 1 design;Hybrids;Impairment;implementation determinants;implementation intervention;implementation research;implementation science;implementation strategy;improved;improvement on sleep;indexing;Individual;innovation;Intervention;Knowledge;Lead;Medicine;Mental Depression;Metabolic syndrome;Methods;Modeling;modifiable risk;mortality;Occupations;Outcome;Persons;Pharmaceutical Preparations;Phase;poor sleep;Population;Populations at Risk;Positioning Attribute;post implementation;preference;primary outcome;process evaluation;professional atmosphere;programs;Promoting Action on Research Implementation in Health Services framework;Provider;Psychotherapy;Public Health;Questionnaires;Randomized;randomized trial;Randomized, Controlled Trials;Readiness;reduce symptoms;Reporting;Research;Research Priority;research to practice;resilience;Rewards;Risk;Safety;Schedule;secondary outcome;Shift-Work Sleep Disorder;Sleep;Sleep Apnea Syndromes;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep health;sleep quality;Sleeplessness;social norm;Solid;Symptoms;System;Testing;theories;Translating;Translations;treatment as usual;United States;United States Department of Veterans Affairs;United States National Institutes of Health;Vulnerable Populations;Wellness Program;Work;Workplace

PROJECT_TITLE: Assessing Clinical Effectiveness and Implementation of Worksite Sleep Health Coaching in Firefighters

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Interstitial Cystitis;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Urologic Diseases

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PHR: PROJECT NARRATIVE There is a critical need to improve the diagnosis and treatment of pain that is associated with bladder disease, including referred pain that is common amongst patients yet poorly understood. The proposed research will provide a necessary understanding of the peripheral molecular and neurophysiologic mechanisms underlying referred pain by identifying how neighboring uninjured sensory neurons housed within the same sensory ganglion, yet innervating distant organs, are altered in mouse models of bladder inflammation and nerve injury. Findings from this research will demonstrate peripheral novel mechanism for referred pain with specific molecular targets outside of the blood-brain-barrier that can be exploited to develop more suitable therapies for patients with referred pain.

PI_NAMEs: TRAN, EMILY L (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acrolein;Address;Adenosine Triphosphate;Affect;Afferent Neurons;Automobile Driving;behavior measurement;Behavioral;Biological;Biological Assay;Bladder;Bladder Diseases;Bladder Dysfunction;Bladder Injury;bladder pain;Blood - brain barrier anatomy;Body part;capsaicin receptor;Central Nervous System;Chemicals;Clinic;Communication;Creativeness;Curiosities;Cystitis;Data;dermatome;design;Development;Diagnosis;Diagnostic;Distant;experience;Experimental Designs;experimental study;Exposure to;Functional disorder;Ganglia;Human;Hypersensitivity;improved;Inflammation;injured;Injury;intercellular communication;Interneurons;Interstitial Cystitis;Label;Link;Literature;Lower Extremity;Measures;Mechanics;Mediating;member;Membrane;Modeling;Molecular;Molecular Target;mouse model;Mus;Nerve;nerve damage;nerve injury;nerve supply;Neurogenic Bladder;Neuroglia;neuronal excitability;Neurons;neurophysiology;Neurosciences;novel;Organ;Pain;Pain Attribute;Pain management;Pain Measurement;painful neuropathy;Pathology;Patients;Pattern;Pelvic Pain;Peripheral;Peripheral Nervous System;Phenotype;Physiological;Play;Preparation;protein expression;Purinoceptor;Quality of life;receptor;receptor expression;Research;response;Rodent Model;Role;Sensory;Sensory Ganglia;Signal Transduction;Site;Skin;skin biopsy;spared nerve;Spinal;Spinal Cord;Spinal Ganglia;sural;Syndrome;Testing;Therapeutic;therapeutically effective;Tissues;Tracer;Training;TRP channel;TRPV1 gene;Urology;Visceral;women patients

PROJECT_TITLE: Receptor-mediated dysfunction of satellite glia and uninjured sensory neurons as a novel link between referred neuropathic pain and bladder disease


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: PROJECT NARRATIVE Physiological aging and age-related diseases are highly associated with protein aggregation, but the causal relationship between protein aggregation and aging remains unknown. This proposal utilizes novel and complementary approaches to directly test the hypothesis that aging at the cellular level is ultimately driven by irreversible conformational transitions in physiologically supersaturated proteins (i.e. proteins existing at concentrations exceeding their solubility limits). The insights generated from this research will be the first to directly test a thermodynamic explanation for aging in humans - potentially providing new opportunities to decelerate the onset of age-related diseases.

PI_NAMEs: VON SCHULZE, ALEX  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Acceleration;Age;age acceleration;Age of Onset;age related decline;age-related disease;aged;Aging;aging mechanism;aging process;aging related;Amyloid;biological age;Biological Process;cell age;Cell Aging;Cell Nucleus;Cell Physiology;Cells;Characteristics;Clinical;conformational conversion;Cytoplasm;Cytosol;Data;Deceleration;Deposition;design;Development;DNA Methylation;drivers of aging;driving force;Epigenetic age;epigenetic clock;Epigenetic Process;Event;experimental study;Feedback;Fibroblasts;Fluorescence Resonance Energy Transfer;Foundations;Genetic Transcription;Goals;hallmarks of aging;Human;insight;Intrinsic drive;Investigation;Kinetics;Libraries;Light;Mass Spectrum Analysis;Measures;Molecular;Molecular Conformation;novel;novel therapeutics;Nuclear;Nuclear Export;Nuclear Proteins;Phase;Physiological;polypeptide;prediction algorithm;Prevention;Process;protein aggregation;Proteins;Proteome;Proteomics;proteostasis;proteostasis loss;rate of aging;Reporter;Reporting;Research;Research Personnel;Role;self assembly;Solubility;Testing;Thermodynamics;Time;transcriptome sequencing

PROJECT_TITLE: Investigating protein supersaturation as a driver of aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


PHR: PROJECT NARRATIVE  Cells must constantly reprogram mitochondrial function to adapt to changing cellular environments and support cell homeostasis. This project aims to elucidate how movement of the mitochondrial network and mitochondrial signaling pathways contribute to cellular fitness. Because mitochondria are key organelles that maintain cellular homeostasis, and mitochondrial dysfunction are associated with neurological and metabolic diseases, cancer and aging, our advances have the potential to inform how to exploit these mechanisms for practical applications in medicine.

PI_NAMEs: CAINO, MARIA CECILIA (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Aging;cell motility;cell type;Cells;Cellular biology;Communication;Complex;Crista ampullaris;Cytoskeleton;Environment;Epithelial Cells;fitness;Focal Adhesions;Goals;Homeostasis;Location;Malignant Neoplasms;Mammalian Cell;Medicine;Membrane;Metabolic Diseases;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Morphology;Movement;Nervous System Disorder;Neuroglia;Neurons;novel;Organelles;Pathway interactions;practical application;Process;programs;Protein Isoforms;protein transport;Proteins;Regulation;Research;Signal Pathway;Signal Transduction;spatiotemporal;Supporting Cell;Time;trafficking

PROJECT_TITLE: Regulation of mitochondrial dynamics pathways in mammalian cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Rett syndrome (RTT) is a severe neurodevelopmental disorder that is notable for its postnatal onset: after 12- 18 months of apparently normal development and reaching the expected milestones, females with mutations in the X-linked MECP2 gene lose their acquired skills and develop a host of neurological symptoms. Mecp2- deficient mice faithfully reproduce this pattern, even when Mecp2 is suppressed in adult mice: it takes weeks for them to develop symptoms. This lag between loss of MeCP2 function and the onset of symptoms allows us to track the molecular changes that follow Mecp2 depletion in mice so that we better understand the pathways involved, and also provides a window of opportunity for interventions that can delay or prevent the onset of disease.

PI_NAMEs: ZOGHBI, HUDA Y (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Acute;Adult;Anatomy;Antibodies;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Appearance;Apraxia;Ataxia;Behavioral;Bite;Brain;Cell Nucleus;Chromatin;Cleavage Under Targets and Release Using Nuclease;Collaborations;Data;Deep Brain Stimulation;design;Deterioration;Development;Disease;disease-causing mutation;DNA;DNA Binding;dosage;Electrophysiology (science);Epigenetic Process;Event;Exons;Female;functional improvement;Gene Deletion;Gene Expression;gene therapy;Genes;genetic manipulation;Genetic Transcription;Germ Lines;girls;Health;Heterozygote;Hippocampus;Histones;improved;insight;Intervention;Knock-out;Knockout Mice;Learning;Life;Link;loss of function mutation;Maintenance;male;Manuscripts;Maps;Measures;MeCP2 Duplication Syndrome;Mediating;Memory;Memory impairment;Methodology;Methyl-CpG-Binding Protein 2;Molecular;Morphology;morris water maze;mosaic nature;Motor;motor deficit;mouse model;Mus;Mutation;Natural History;Nature;Nervous System Physiology;neural circuit;neural stimulation;Neurodevelopmental Disorder;Neurologic Dysfunctions;Neurologic Symptoms;Neurons;neurophysiology;Onset of illness;Pathogenesis;Pathway interactions;Pattern;pharmacologic;Pharmacologic Substance;Phenotype;Physiological;postnatal;prevent;Production;Protein Isoforms;Proteins;response;response biomarker;Rett Syndrome;Rod;Rotation;Seizures;Severities;Site;skill acquisition;stereotypy;Symptoms;Testing;Therapeutic;therapeutic biomarker;therapeutic target;Training;Translating;treatment response

PROJECT_TITLE: MOLECULAR PATHOGENESIS STUDIES OF RETT SYNDROME


NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: This project will determine how plants uses salicylic acid to control cell death and survival to combat infection while avoiding conflict with growth-related activities. Results from the study will lead to development of new strategies of engineering crop varieties with enhanced broad-spectrum resistance to reduce the use of pesticides which are major health and environmental hazards. Moreover, studying salicylic acid’s broad physiological functions in plants may also shed light on its medicinal effects in animals because salicylic acid is the oldest herbal medicine known to mankind used in fever reduction and pain relief and in recent years, aspirin (acetylated salicylic acid) has been repurposed in treating cardiovascular diseases and certain types of cancer.

PI_NAMEs: DONG, XINNIAN  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acetylation;Address;Agriculture;Animals;Apoptosis;Aspirin;Biological Response Modifiers;Biology;cancer type;Cardiovascular Diseases;Cell Death;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Chemicals;circadian pacemaker;Clinical Trials;Colon Carcinoma;combat;Complex;Conflict (Psychology);Cytoplasm;Desiccation;Development;Distal;drug efficacy;Engineering;Ensure;Environmental Hazards;Fever;Funding;Genes;genetic analysis;Growth;Health;Health Hazards;Hemorrhage;Herbal Medicine;Immune response;Immune signaling;Immune system;Immunity;immunoregulation;Infection;Mediating;Medicine;Mission;Modeling;Molecular;mutant;National Institute of General Medical Sciences;Non-Insulin-Dependent Diabetes Mellitus;Nuclear;Nuclear Pore Complex;Nuclear Translocation;Organism;pain relief;pathogen;Periodicity;Permeability;Pesticides;Physical condensation;Physiological;Plant Growth Regulators;Plants;Play;Process;Production;programs;Regulation;Research;Resistance;Role;Salicylic Acids;side effect;Site;Testing;Time;Tissues;transcriptome;ubiquitin ligase

PROJECT_TITLE: Salicylic  Acid in Immunity and Health: A Small Phytohormone with Big Physiological Impacts

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Improving the health of our nation requires collaboration among teams of biomedical scientists, health care providers, community members, patients, and policymakers. The goal of this proposal is to engage such teams in a national effort to translate new scientific discoveries into clinical practice to improve health. Project Narrative Page 165

PI_NAMEs: TOTO, ROBERT DANIEL (contact)

PROGRAM_OFFICER_NAME: CONROY, JENNIE LYNN

PROJECT_TERMS: academic program;Acceleration;Address;Adoption;Artificial Intelligence;Basic Science;biomedical scientist;catalyst;Clinical;clinical practice;Clinical Research;Clinical Trials;Collaborations;collaborative environment;Communication;Communities;community engagement;community partners;Data;Data Collection;design;Education;Ensure;Entrepreneurship;Environment;equity, diversity, and inclusion;ethnic diversity;Faculty;Family;Fostering;Foundations;Funding;Goals;Health;Health Personnel;Healthcare;Healthcare Systems;Heterogeneity;improved;Individual;Industry;Informatics;informatics training;innovation;Institution;Intervention;Leadership;life span;member;Mentors;Methods;Mission;multimodality;novel;novel strategies;Outcome;Patients;personalized medicine;Phase;point of care;Policy Maker;Population;population health;Population Heterogeneity;pre-clinical;Process;programs;Published Comment;Qualitative Methods;racial diversity;recruit;Reproducibility;Research;research to practice;Resources;Rural Community;Rural Population;Science;Scientist;Services;skills;Special Population;success;Teaching Hospitals;Technology;Testing;Texas;tool;Training;Training and Education;Training Programs;Translating;Translation Process;translational medicine;Translational Research;Translations;Underserved Population;Urban Community;Urban Population;user-friendly

PROJECT_TITLE: UT Southwestern Center for Translational Medicine


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: MISCELLANEOUS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative Preterm birth (PTB) affects 1 in 7 Black babies born in the US. This would be the first large-scale prospective birth cohort study to address critical questions regarding the preterm origin of cardiometabolic risk in a sample of a predominantly US urban, low-income, Black participants who are disproportionally affected by both PTB and cardiometabolic diseases. Successful completion of this study will help identify novel predictive biomarkers and therapeutic targets so that high-risk newborns can be identified, and effective interventions can be initiated during the earliest developmental windows when they may have the greatest life-long benefit.

PI_NAMEs: HU, FRANK B;WANG, XIAOBIN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: 18 year old;2 year old;37 weeks gestation;Address;Adult;Affect;Age;Archives;Beginning of Life;Biological;Biological Assay;biological specimen archives;Birth;Black Populations;Black race;Blood;blood pressure elevation;Boston;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;case control;Cause of Death;Child;Chronic Disease;Clinical;cohort;Cohort Studies;Collection;computer infrastructure;cost;Data;Databases;design;Development;Diabetes Mellitus;Disparity;Dose;early childhood;early detection biomarkers;effective intervention;Enrollment;Environmental Risk Factor;Epidemiology;epigenome;excessive weight gain;follow-up;Funding;Future;Genetic;Genome;Health;health disparity;high risk;impaired glucose tolerance;Individual;Infant;Insulin;Intervention;Investigation;Joints;Journals;Laboratories;Life;Life Cycle Stages;Link;Lipids;Longitudinal Studies;Longterm Follow-up;Low income;Metabolic dysfunction;metabolome;metabolomics;Minority Groups;Mothers;multiple omics;neonatal period;Neonatology;Newborn Infant;novel;novel marker;Obesity;Obstructive Sleep Apnea;Outcome;Overweight;Participant;Pathway interactions;Peer Review;Perinatal;Phenotype;Pilot Projects;Plasma;Population;postnatal;predictive marker;premature;Premature Birth;prenatal;preterm newborn;prospective;protective factors;Proteins;Proteome;Proteomics;Publications;Research;Research Design;Resources;response;Risk;Risk Assessment;Risk Factors;Sampling;sex as a biological variable;Technology;Term Birth;therapeutic target;Time;tool;Umbilical Cord Blood;United States National Institutes of Health;Venous

PROJECT_TITLE: Preterm Birth and Child Long-term Cardiometabolic Risk: Integrate Proteomics with Birth Cohort

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Project Narrative The objective of this research program is to invent new catalytic synthetic protocols for high value transformations of simple hydrocarbon-containing compounds typically found in most pharmaceuticals. We will use simple light-harvesting organic dyes that act as powerful single electron oxidants to effect single electron transfer reactions to generate highly reactive radical species that will be allow for the rapid derivatization of medicinal agents.

PI_NAMEs: NICEWICZ, DAVID A (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: New Catalytic Methods for the Synthesis of Complex Molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative We see the world with our retinas, which send visual signals to many parts of the brain including the superior colliculus, a major locus for attention and decision-making. Analyzing the direct connection from retina to superior colliculus is critical for understanding vision and attentional disorders such as ADHD. We will apply new approaches that combine genetic targeting of retinal cells that project to the superior colliculus along with high- density recording and manipulation of those cells to provide a full accounting of the signaling and functionality of this circuit in rat and primate animal models.

PI_NAMEs: FIELD, GREGORY DARIN (contact);SOMMER, MARC A

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Accounting;Animal Model;Area;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;awake;Axon;Behavior;Behavioral;Biological Models;Biomedical Research;Blindness;Brain;Catalogs;Cell Communication;cell type;Cells;Classification;Classification Scheme;Data;Decision Making;Dedications;density;design;Disease;Dorsal;Electrophysiology (science);Endowment;experimental study;fascinate;Future;Genes;Genetic;Genetic Techniques;Glaucoma;Goals;Human;Impairment;in vivo evaluation;Infection;Injections;insight;Knowledge;Label;Lateral Geniculate Body;Learning;Light;Logic;Macaca;Macaca mulatta;Mammals;Measures;Methods;Modeling;Monkeys;Morphology;multi-electrode arrays;Mus;Neurosciences;nonhuman primate;novel;novel strategies;optic nerve disorder;optogenetics;orientation selectivity;Outcome;Output;Pathway interactions;Pattern;Physiology;Play;Population;Primates;Process;promoter;Property;Proteins;Rattus;receptive field;Recombinant adeno-associated virus (rAAV);Reporter;Research;Research Support;response;Retina;Retinal Diseases;Retinal Ganglion Cells;Retinitis Pigmentosa;retinogeniculate;retinotectal;Rodent;Role;Shapes;signal processing;Signal Transduction;superior colliculus Corpora quadrigemina;Techniques;Testing;Transgenic Animals;Translating;transmission process;United States National Institutes of Health;Viral;Virus;Vision;Visual;visual motor;Visual Pathways;visual processing;Visual System;Work

PROJECT_TITLE: Visual signaling from retina to superior colliculus


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Drugs of abuse alter dopamine signaling in the ventral striatum during reward learning. This project will investigate how dopamine dynamics encode variables during reward learning in a way that has previously been overlooked. Gaining a better understanding of mesostriatal dopamine dynamics during reward learning can potentially uncover novel therapies for drug addiction.

PI_NAMEs: GARR, ERIC  (contact)

PROJECT_TERMS: addiction;Association Learning;Attention;Auditory;Axon;Behavior;Behavior Control;Belief;Cells;cohort;Communication;conditioning;Corpus striatum structure;Cues;Dependence;Dopamine;dopaminergic neuron;drug addiction therapy;drug craving;drug of abuse;Environment;Event;experience;experimental study;Fiber;Future;Genetic Recombination;Goals;Human;Image;insight;Investigation;Learning;Machine Learning;Measures;Mediating;Methods;Midbrain structure;Modeling;Movement;N-Methyl-D-Aspartate Receptors;neural;Neurons;Neurosciences;neurotransmitter release;novel therapeutics;Nucleus Accumbens;Opsin;optogenetics;Phase;Photometry;Physiological;Population;postsynaptic;Presynaptic Terminals;Protocols documentation;Psychological reinforcement;Rattus;Receptor Activation;Relapse;Reporting;Research;response;Rewards;Rodent Model;Role;Signal Transduction;Spottings;Sum;Synapses;Synaptic plasticity;theories;Time;Ventral Striatum;Ventral Tegmental Area;Video Recording

PROJECT_TITLE: Mesostriatal dopamine in Pavlovian reward rate learning


NIH_SPENDING_CATS: Autoimmune Disease;Contraception/Reproduction;Estrogen;Genetics;Immunotherapy;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Transplantation;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Pregnancy represents a unique physiological situation in which there the fetus is tolerated by the maternal immune system despite its expression of not only foreign, paternally inherited antigens, but also tissue specific antigens. Immune tolerance to many tissue specific antigens is established in the thymus by the process of central tolerance; however, almost nothing is known about the role of central tolerance in maternal tolerance to the fetus. Understanding this process will lead us to novel insights into how diseases of pregnancy can be alleviated and will have far-reaching implications for women’s wellbeing in the fields of pregnancy, reproductive health, autoimmune disease, transplantation, and cancer immunology.

PI_NAMEs: PETROFF, MARGARET G (contact)

PROJECT_TERMS: Adult;age related;Allografting;Antigens;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;base;blastocyst;Cells;central tolerance;combat;Data;Diagnosis;Disease;Embryo;Embryo Loss;embryo quality;Embryo Transfer;embryo/fetus antigen;embryonic stem cell;Ensure;Estrogens;experimental study;failure Implantation;female fertility;Fertility;fetal;Fetal Growth Retardation;fetal loss;Fetus;Foundations;Gene Expression;Genes;Genetic Transcription;Goals;Gonadal Steroid Hormones;Gonadal structure;Gravid;healthy pregnancy;Hormones;Immune;immune function;Immune system;Immune Tolerance;Immunologic Surveillance;Immunosuppression;implantation;In Vitro;in vivo;in vivo Model;Infertility;Inherited;insight;intimate behavior;Knockout Mice;Knowledge;Link;Malignant Neoplasms;Maps;maternal immune system;Maternal-Fetal Exchange;Mediating;mouse model;Mus;natural Blastocyst Implantation;novel;Oocytes;Ovarian;Ovary;Peripheral;Personal Satisfaction;Physiological;Placenta;Play;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy loss;Pregnancy Outcome;Premature Birth;Prevention strategy;Process;Progesterone;progesterone receptor A;Progesterone Receptors;Proteins;Regulation;Regulatory T-Lymphocyte;Reporting;Reproduction;reproductive;reproductive function;Reproductive Health;reproductive outcome;Reproductive system;reproductive tract;Research;Role;societal costs;T cell infiltration;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;Time;Tissues;transcription factor;Transplantation Immunology;tumor immunology;Uterus;Woman;Work

PROJECT_TITLE: Maternal Central Immune Tolerance in Reproduction

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PHR: PROJECT NARRATIVE Transport proteins in the liver are critical determinants of drug disposition, efficacy, and toxicity, but factors that alter hepatic transporter function are poorly understood, and more efficient and robust predictive tools are needed. These studies will answer fundamental questions related to hepatic transport mechanisms and transporter-mediated drug interactions, and advance innovative strategies to assess interindividual variability in transporter function. Data generated will inform the development of in silico models to predict drug disposition more accurately and improve therapeutic outcomes.

PI_NAMEs: BROUWER, KIM L.R. (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: 3-Dimensional;Address;bile acid transporter;Bile Acids;Biliary;Biological Markers;Carrier Proteins;cholangiocyte;clinical predictors;Data;defined contribution;Development;drug disposition;drug efficacy;Drug Interactions;Drug Kinetics;Drug Transport;Excretory function;exosome;Goals;Grant;Hepatic;Hepatocyte;Homeostasis;Human;improved;in silico;In Vitro;in vivo;inhibitor;innovation;inter-individual variation;Laboratories;Liver;Mediating;Methods;Modeling;National Institute of General Medical Sciences;novel;novel strategies;Organoids;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phenotype;Phosphorylation Site;Physiological;Play;predictive tools;programs;Regulation;Research;response;Role;Safety;Science;solute;System;therapy outcome;tool;Toxic effect;trafficking

PROJECT_TITLE: Mechanisms of Altered Hepatic Transport: Impact on Drug Therapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF) remain the leading causes of mortality in the U.S. Currently, we do not fully understand and cannot predict why some individuals develop ASCVD and HF. We intend to apply a novel method that measures nearly 5000 proteins to discover new, potentially modifiable proteins that could help us predict cardiovascular risk and pave the way to new therapies.

PI_NAMEs: DEO, RAJAT ;DUBIN, RUTH ;GANZ, PETER  (contact)

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: aptamer;Atherosclerosis;atherosclerosis risk;Atherosclerosis Risk in Communities;Binding;Biological;Biological Assay;Biological Markers;Biology;Calibration;Cardiac;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Clinical;cohort;coronary artery calcification;Coronary heart disease;design;Development;Discrimination;Disease;Event;Goals;Heart Atrium;Heart failure;Heterogeneity;improved;Incidence;Individual;Investigation;Learning;Left;Left Ventricular Ejection Fraction;Left Ventricular Mass;Measurement;Measures;men;Methods;Modeling;mortality;Multi-Ethnic Study of Atherosclerosis;novel;novel therapeutics;Outcome;Participant;Pathway Analysis;Pathway interactions;Patients;Persons;Plasma;Plasma Proteins;pointed protein;prevent;Prevention strategy;protein biomarkers;Proteins;Proteomics;Provider;Race;racial difference;racial diversity;Reagent;Recommendation;recruit;Risk;Risk Factors;risk prediction;Sampling;Scanning;sex;Sex Differences;Technology;Testing;Time;Ventricular;Visit;Woman

PROJECT_TITLE: Proteomics of Cardiovascular Risk: The Multiethnic Study of Atherosclerosis

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Cancer;Kidney Disease;Prostate Cancer;Radiation Oncology;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE By providing robust and durable responses, a novel radiotherapeutic agent called [225Ac]-PSMA- 617 has the potential to change the treatment landscape for end-stage prostate cancer patients, and has delivered impressive results in clinical trials, including some complete responses. Treatment with [225Ac]-PSMA-617, however, is severely limited by salivary gland toxicity. In response, we are proposing aclinically translatable method to refine treatment with [225Ac]-PSMA- 617 and other PSMA-TRT agents by reducing toxicity to salivary glands and kidneys without compromising treatment efficacy, helpingto extend the lives of mCRPC patients while maintaining their quality of lif e.

PI_NAMEs: PILLARSETTY, NAGAVARAKISHORE  (contact)

PROGRAM_OFFICER_NAME: CAPALA, JACEK

PROJECT_TERMS: acute toxicity;Address;Aftercare;androgen independent prostate cancer;Antigen Targeting;Biodistribution;burden of illness;Cancer Patient;Cessation of life;Chemicals;Clinic;clinical translation;Clinical Trials;clinically relevant;Collection;Communities;CWR22Rv1;Data;Discipline of Nuclear Medicine;Disease;Dose;Dose Limiting;Drug Kinetics;effective therapy;Effectiveness;Eligibility Determination;exhaust;experimental study;FOLH1 gene;Genitourinary system;Human;Immunohistochemistry;In complete remission;in vivo;innovation;Institution;Intellectual Property;Irreversible Toxicity;Kidney;Kinetics;Lead;Lesion;Ligands;LNCaP;Maintenance;Malignant neoplasm of prostate;Medical;Methodology;Methods;Modeling;mouse model;Mus;Neoplasm Metastasis;nephrotoxicity;novel;Oncologist;Organ;Pathologist;patient subsets;Patients;PC3 cell line;Peptides;Performance;Pharmacology and Toxicology;Physicians;Physiological;Positron-Emission Tomography;Preparation;Production;prostate cancer model;Qualifying;Quality of life;Radiation Dose Unit;Radiation therapy;Radioisotopes;Radionuclide therapy;Radiopharmaceuticals;Rattus;Reducing Agents;Refractory;Renal function;Research;Research Personnel;response;Safety;Saliva;Salivary Glands;Salvage Therapy;Serum;side effect;small molecule;Structure of base of prostate;Testing;Toxic effect;Toxicology;Treatment Efficacy;Treatment Side Effects;tumor;Tumor Burden;tumor xenograft;uptake;Xenograft Model;Xenograft procedure;Xerostomia

PROJECT_TITLE: Minimizing salivary gland and renal toxicity arising from PSMA-targeted alpha therapy

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ORG_CITY: HOUSTON

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: NARRATIVE The obesity epidemic in the United States continues to contribute to the rise of metabolic disorders like type 2 diabetes and cardiovascular diseases. This proposal will characterize a new liver-secreted hormone that mitigates inflammation in adipose tissues and exerts beneficial metabolic impacts against obesity and type 2 diabetes.

PI_NAMEs: KIM, KANGHO  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Ablation;Acceleration;Adipocytes;Adipose tissue;Animal Model;Anti-diabetic Drugs;Anti-Inflammatory Agents;Antiinflammatory Effect;bariatric surgery;Bile Acids;Biliary;Binding;Body Composition;Body Weight decreased;Cardiovascular Diseases;CCR5 gene;Cell Physiology;Certification;chemokine receptor;Cholic Acids;Communication;Coupled;Data;Diabetes Mellitus;Diet;Distal;Endocrine;energy balance;Energy Metabolism;Fatty Acids;Feedback;Functional disorder;Genes;Goals;Hepatic;Hormone secretion;Immune;improved;Inflammation;Inflammatory;Inflammatory Response;innovation;insight;Insulin;insulin sensitivity;insulin sensitizing drugs;Interferon Type II;Intervention;Knockout Mice;Link;Lipids;Liver;liver injury;Mediator;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic stress;Metabolism;Molecular;Molecular Profiling;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear;Obese Mice;Obesity;Obesity Epidemic;obesity treatment;Operative Surgical Procedures;Organ;Orosomucoid;overexpression;Pathway interactions;Peripheral;Phenocopy;Phenotype;receptor;Regulation;response;Role;Signal Transduction;STAT1 protein;surfactant function;Testing;Therapeutic;Tissues;United States;Weight

PROJECT_TITLE: THE ROLE OF HEPATOKINE ORM2 IN ADIPOSE TISSUE INFLAMMATION

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Childhood Injury;Heart Disease;Infant Mortality;Lung;Neonatal Respiratory Distress;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Unintentional Childhood Injury

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: NARRATIVE The proposed research is critical for public health as the practice of providing external chest compressions in newborn when their heart rate is low at birth lacks evidence and could influence the outcome of neonatal resuscitation. Exploring the current and alternate strategies to improve oxygenated blood flow to brain & heart, and provide optimal support while limiting injury during external chest compressions may provide evidence that can improve newborn care. The current proposal is extremely relevant to current NIH/NICHD’s mission of protecting and enhancing the lives of newborn/children by optimizing the current practice of performing external chest compressions during neonatal resuscitation.

PI_NAMEs: CHANDRASEKHARAN, PRAVEEN  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Adult;Apical;Asphyxia;Asphyxia Neonatorum;Auscultation;Autopsy;Biological Markers;Birth;Blood;Blood flow;blood flow measurement;Bradycardia;Brain;Brain Injuries;brain magnetic resonance imaging;Cardiac;Cerebrospinal Fluid;Cerebrovascular Circulation;Cerebrum;Chest;Child;Childhood;Circulation;Coronary;Creatinine;Data;Delivery Rooms;Depressed mood;Detection;Diastole;Diastolic blood pressure;Dose;Drops;Electrocardiogram;endotracheal;Epinephrine;Event;Experimental Designs;Expert Opinion;Frequencies;Gases;global health;Goals;Guidelines;Heart;heart damage;Heart Injuries;Heart Rate;heart rhythm;hemodynamics;Hour;Human;Hypoxia;Imaging Techniques;Impairment;improved;Incidence;Infant;Infant Care;Injury;instrument;instrumentation;Interleukin-6;International;Intravenous;lamb model;lung development;Measures;Methods;Mission;Modeling;Monitor;Myocardial;myocardial injury;Myocardial perfusion;Myocardium;National Institute of Child Health and Human Development;Nature;Neonatal Mortality;neonatal resuscitation;neonate;Newborn Infant;novel;novel strategies;Organ;Outcome;Perfusion;Pharmaceutical Preparations;Phase;Phosphotransferases;Physiologic pulse;Population;Pregnancy;pressure;programs;Protocols documentation;Public Health;Recommendation;Reporting;Research;Resuscitation;Risk;Role;Science;Secondary to;Serum;sheep model;Systole;Testing;Time;Tissue Stains;Tissues;TNF gene;Translating;Treatment Protocols;tripolyphosphate;Troponin I;Troponin T;United States National Institutes of Health;ventilation

PROJECT_TITLE: Optimizing Chest Compressions for Bradycardia during Neonatal Resuscitation

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Restoration of dental, oral, and craniofacial (DOC) tissues lost to disease, injury or congenital disorders is a major objective of oral reconstructive therapy. The goal of the Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center is to translate tissue engineering and regenerative medicine innovations that address the ongoing clinical need to restore or create healthy, functional DOC tissues. The vision of this Resource Center is that the most promising technologies will be catalyzed by novel academic partnerships to safely and effectively regenerate, reconstruct and restore functional DOC tissues, leading to a transformation of patient care.

PI_NAMEs: GIANNOBILE, WILLIAM V;KOHN, DAVID H. (contact);MOONEY, DAVID J;SFEIR, CHARLES ;WAGNER, WILLIAM R

PROGRAM_OFFICER_NAME: MELILLO, AMANDA A

PROJECT_TERMS: Acceleration;Address;Adoption;Area;California;Catalysis;Clinical;clinical development;clinical implementation;clinical practice;clinical translation;Clinical Trials;cohort;Collaborations;commercialization;Communities;Community Medicine;Companions;Congenital Disorders;craniofacial;craniofacial tissue;Dental;Dentistry;Development Plans;Disease;empowerment;Extramural Activities;first-in-human;forging;functional restoration;Funding;Goals;Human;Industrialization;Industry;Infrastructure;Injury;innovation;Institution;Marketing;Medicine;Michigan;National Institute of Dental and Craniofacial Research;Natural regeneration;novel;Oral;oral tissue;organ regeneration;organizational structure;outreach program;Pathway interactions;Patient Care;pre-clinical;preclinical study;Private Practice;Probability;Process;product development;programs;reconstruction;Regenerative Medicine;Resources;restorative dentistry;Risk;Secure;Services;Standardization;Structure;success;System;Technology;technology validation;Tissue Engineering;tissue regeneration;training opportunity;Translating;Translations;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center: Advancing Dental, Oral, and Craniofacial Regeneration to Clinical Trial Initiation


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative The bone morphogenetic protein (BMP) family of inductive growth factors acts in a reiterative signal specific manner to direct neural progenitor cells in the dorsal spinal cord to proliferate and then differentiate into the distinct classes of interneurons (dIs) that integrate and relay sensory information from the periphery. We are examining the extrinsic and intrinsic mechanisms that translate the activity of the BMPs into specific populations of dIs. These studies will shed light both on our ability to rebuild damaged spinal cords, as well as understanding the basis of the congenital diseases that result from altered BMP signaling.

PI_NAMEs: BUTLER, SAMANTHA J (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Adopted;Aftercare;BMP4;bone morphogenetic protein receptor type I;Bone Morphogenetic Proteins;Cell model;cell type;Cells;Chicken Model;Chickens;ChIP-seq;Complex;Data;design;Development;Developmental Biology;differentiation protocol;Disease;Dorsal;Drug Modulation;Drug Screening;drug testing;Environment;ES Cell Line;Family;Family member;Gene Expression Profiling;Genetic Transcription;Germ Cells;Growth Factor;In Vitro;in vivo;Individual;Injury;Interneurons;knock-down;Ligands;Light;Logic;Mediating;Medical;member;Modality;Modeling;morphogens;motor control;Mouse Embryonic Stem Cells;mouse model;Mus;Nature;nerve stem cell;neural;Nociception;Outcome;Pain;Paralysed;Pathway interactions;Patients;Pattern;Peripheral;Pluripotent Stem Cells;Population;Process;Production;progenitor;Proliferating;Proprioception;Protein Family;Protocols documentation;Pruritus;Reaction;receptor;repaired;Research;Resolution;response;Role;Second Messenger Systems;Sensory;Series;SHH gene;Signal Pathway;Signal Transduction;Signaling Protein;small molecule inhibitor;somatosensory;Specific qualifier value;Spinal;Spinal Cord;Spinal cord damage;stem cell differentiation;stem cell fate;stem cell model;Subgroup;System;Touch sensation;transcription factor;transcriptome;transcriptomics;Translating;Tretinoin;Well in self;WNT Signaling Pathway

PROJECT_TITLE: Assessing the mechanisms directing cell fate in the dorsal spinal cord


ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative The United States Food and Drug Administration is planning to implement a ban on menthol cigarettes, and the future of e-liquid flavoring, including menthol, remains unclear. The proposed project will be among the first randomized controlled trials to assess the impact of a cigarette menthol ban and an e-cigarette menthol ban on cigarette use, e-cigarette use, and the ability to abstain from smoking among current menthol smokers.

PI_NAMEs: SMITH, TRACY TAYLOR (contact)

PROGRAM_OFFICER_NAME: FITZ-RANDOLPH, MARCY ESTHER

PROJECT_TERMS: Adherence;Adult;Advocacy;Advocate;attributable mortality;Behavior;Biological Markers;Calibration;Canada;Carbon Monoxide;Cessation of life;Characteristics;Cigarette;cigarette smoke;cigarette smoking;Clinical Trials;Cotinine;Coupled;Data;demographics;Dependence;design;diaries;Electronic cigarette;electronic cigarette use;electronic liquid;Electronics;Ensure;Europe;experimental study;Face;Flavoring;Future;Health Benefit;Heterogeneity;Incentives;Individual;Intention;Legal;Litigation;Marketing;Medicine;Menthol;Methodology;Modeling;Nicotine;nicotine exposure;non-cigarette tobacco product;Participant;Patient Self-Report;Pattern;Policies;Population;population health;primary outcome;Probability;Process;prospective;Public Health;public policy on tobacco;Randomized, Controlled Trials;Regulation;Research Design;Research Priority;secondary outcome;Smoke;Smoker;Smoking;smoking cessation;Source;Study models;success;Techniques;Testing;Time;Tobacco;tobacco flavor;Tobacco Industry;tobacco products;Tobacco use;treatment effect;Uncontrolled Study;United States;United States Food and Drug Administration;urinary;vaping;Vulnerable Populations;years of life lost

PROJECT_TITLE: The impact of menthol regulation for cigarettes and e-cigarettes on tobacco use patterns for current menthol smokers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-P(56)]


NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: SPRINGFIELD

ORG_NAME: NORTH AMERICAN ASSN/CENTRAL CANCER REG

PHR: NAACCR Annual Scientific Conference Project Narrative R13 20-207 For more than 30 years, NAACCR has hosted the most influential and informative annual scientific conference for cancer surveillance professionals. Drawing from every state and province in the US and Canada, as well as international colleagues, the NAACCR Annual Conference is attended by over 400 researchers, epidemiologists, and cancer surveillance scientists annually. Developed by and for cancer surveillance professionals, it is the largest meeting of its kind to share research findings, develop innovative methodologies, support cancer research, and ensure a community that is well-informed on advances in cancer care, data sources, technology, and research interests.

PI_NAMEs: KOHLER, BETSY A (contact)

PROGRAM_OFFICER_NAME: MILLS, ROSE

PROJECT_TERMS: Advanced Malignant Neoplasm;American;anti-cancer research;Award;Biology;Canada;cancer care;Cancer Control;cancer epidemiology;Cancer Patient;Cancer Surveillance Research;Clinical;clinical care;cohort;Collaborations;Collection;Communication;Communities;Consensus;cost effective;Country;Coupled;COVID-19 pandemic;Data;Data Analyses;Data Collection;data ecosystem;Data Science;Data Sources;Discipline;Education;Educational workshop;Ensure;Epidemiologist;Evaluation;Foundations;Future;global health;Goals;Grant;Guidelines;Health;Hybrids;improved;Influentials;innovation;Interdisciplinary Study;interest;International;Learning;Location;Malignant Neoplasms;Measures;meetings;member;Mentorship;Methodology;Methods;Minority;Modeling;Monitor;neoplasm registry;North America;Persons;Pharmacoepidemiology;population based;posters;prognostic indicator;programs;Province;Registries;Research;Research Activity;Research Personnel;research study;Resources;Science;Scientific Advances and Accomplishments;Scientist;Site;Social Distance;Standardization;Students;surveillance data;symposium;Techniques;Technology;Travel;Uncertainty;Underrepresented Populations;Vertebral column;virtual;Woman;Work

PROJECT_TITLE: Support of the North American Association of Central Cancer Registries, Inc. (NAACCR) Annual Scientific Conference


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Racial and Ethnic Minority Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: PROJECT NARRATIVE We seek funding for our new program, Advancing Native American Diversity in Aging Research through Undergraduate Education, within the NIA’s ADAR R25 program (PAR-17-290). This week-long annually offered class concentrates on recruiting undergraduates, especially from Native American backgrounds, and offers exciting and relevant opportunities for training, including virtual options in response to the COVID-19 pandemic, with the goal of launching research careers in the investigation of Alzheimer’s disease and related dementias and the biology of aging. This is achieved through scientific education, mentored projects, and retention of the participants in the NIH research workforce via ongoing career counseling and personal advice, along with annual updates and refresher programs.

PI_NAMEs: SCHATTEN, GERALD  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Achievement;Active Learning;Aging;aging mechanism;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Attention;Biological;Biology of Aging;Boston;career;Cherokee Indian;college;cost effective;COVID-19 pandemic;design;Doctor of Philosophy;Education;Education Projects;education research;Elderly;Ensure;Exercise;Faculty;Funding;Goals;health disparity;improved;innovation;Institute of Medicine (U.S.);Instruction;Investigation;Investments;Laboratories;Learning;lectures;Medical;medical schools;Mentors;Metabolism;Minnesota;minority scientist;minority trainee;Monitor;Native American population;Native Americans;Nature;next generation;non-Native;Outcome;Participant;participant retention;peer;Population;programs;Recording of previous events;recruit;Research;Research Personnel;Research Training;response;Scientist;Student recruitment;Training;Training and Education;training opportunity;treatment strategy;Tribes;undergraduate education;undergraduate student;Underrepresented Minority;United States National Institutes of Health;Universities;Update;virtual;virtual education;Vocational Guidance

PROJECT_TITLE: Advancing Native American Diversity in Aging Research through Undergraduate Education (Native American ADAR)


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Dietary Supplements;Genetics;Rare Diseases

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative: This research program aims to answer fundamental questions about the control and selectivity of iron-dependent dioxygenase enzymes that remove methyl modifications on cellular mRNA. These methyl ‘eraser’ enzymes are overexpressed in difficult to treat human cancers such as glioblastoma, where their demethylation activity is tied to cancer progression and tumor growth. Successful completion of these projects will show how this class of enzymes is regulated to control mRNA demethylation and inform new approaches for the treatment of human cancers like glioblastoma, where reversible RNA methylation impacts disease.

PI_NAMEs: MUGRIDGE, JEFFREY SCOTT (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acute Myelocytic Leukemia;Ascorbic Acid;Biochemistry;Bioinorganic Chemistry;Biological;Biology;Cells;Cellular biology;Chemicals;cofactor;demethylation;Dioxygenases;Disease;Enzymes;Family;Family member;Glioblastoma;Goals;Human;human disease;insight;Iron;Link;Malignant Neoplasms;Mammalian Cell;Maps;Messenger RNA;Modification;Molecular;Monitor;mRNA capping;novel;novel therapeutic intervention;overexpression;Pathway interactions;Play;programs;Regulation;Research;RNA;RNA methylation;Role;structural biology;Structure;therapeutic target;tool;Transcript;transcriptome;tumor growth;tumor progression;tumorigenesis;Visualization

PROJECT_TITLE: Selectivity and regulation of mRNA demethylation by iron-dependent dioxygenases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]