NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Hypertensive disorders of pregnancy increase the risk of adverse cardiovascular outcomes after delivery, including repeat hypertensive disorders in a subsequent pregnancy. There is a complex interplay between race, ethnicity, and nativity on hypertensive disorders of pregnancy and pathways leading to adverse cardiovascular outcomes. The proposed project will examine inequities in postpartum cardiovascular outcomes by domains of race, ethnicity, and nativity and elucidate the role of postpartum health-related social needs in a safety-net hospital population.

PI_NAMEs: KELLEHER, SAMANTHA PARKER (contact);YARRINGTON, CHRISTINA DECK

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Address;Administrative Supplement;adverse outcome;adverse pregnancy outcome;Affect;Algorithms;Aspirin;Award;Birth;Black race;black women;Blood Pressure Monitors;Boston;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Caring;Chronic;Chronic Disease;Complex;Computerized Medical Record;Country;Data;Discipline of obstetrics;Disparity;electronic medical record system;Epidemiologic Factors;Ethnic Origin;experience;food insecurity;Future;Goals;Health;health assessment;health care service utilization;Health Services;Healthcare;Heterogeneity;high risk;Hispanic;Hispanic Women;hospital readmission;Hospitals;housing instability;Hypertension;Immigrant;Immigration;Incidence;Individual;Inequity;Institution;interest;intersectionality;Intervention;Latina;Letters;maternal morbidity;Maternal-fetal medicine;Mediating;Mediation;Mediator;Medical center;Medical Records;Mexico;Migrant;migration;Morbidity - disease rate;Mothers;Needs Assessment;New England;novel;Outcome;parent grant;parent project;Parents;Pathway interactions;Patient Education;patient population;Patients;Pattern;perinatal outcomes;Persons;Population;postpartum health;Postpartum Hypertension;postpartum outcome;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Premature Birth;Prevalence;Prevention strategy;programs;protective effect;Provider;Race;racial disparity;Recommendation;recurrence prevention;Refugees;Research;response;Risk;Risk Factors;Role;routine screening;safety net;Science;Screening procedure;severe maternal morbidity;social;social health determinants;Social Work;Strategic Planning;System;trend;Trust;United States;United States National Institutes of Health;Woman;Women's Health

PROJECT_TITLE: Postpartum Remote Blood Pressure Monitoring Program: Study of Reducing Severe Maternal Morbidity among Black and Latina Women by Incorporating Patient Experiences and Systems Science

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Climate-Related Exposures and Conditions;Clinical Research;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE As part of the work conducted in Aims 1 and 2 of the parent R01, which focus on estimating the risk of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) and AD-related dementias (ADRD) associated with wildfire PM2.5 (Aim 1) and identifying individual- and area-level susceptibility factors that exacerbate the association between wildfire PM2.5 and MCI and AD/ADRD (Aim 2), we are modeling daily exposure to wildfire- specific PM2.5 levels using a two-stage machine learning (ML) approach. With this administrative proposal, we plan to establish a new collaboration with AI/ML and data experts at Harvard University with the goals of improving the vast and wide range of data sources, developing reproducible pipelines, annotating, documenting, and processing the data, ensuring computational scalability, encouraging community engagement, and disseminating these important AI/ML ready datasets for the prediction of wildfire PM2.5 to a wider research community. Developing robust and reproducible pipelines to make the data inputs ML/AI ready will allow a more rigorous assessment of exposure and therefore will increase the scientific rigor of the results of the parent grant, as well as allow for the datasets to be disseminated to a wide researcher user base.

PI_NAMEs: CASEY, JOAN A (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: 3-Dimensional;Aerosols;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Artificial Intelligence;base;California;Censuses;Collaborations;collaborative environment;Communities;community engagement;Computer software;computerized data processing;Data;data curation;data format;Data Protection;data repository;Data Set;Data Sources;design;Development;Disasters;Disparate;Ensure;Environmental Wind;Exposure to;FAIR principles;fine particles;Fire - disasters;Foundations;Future;Goals;hazard;Humidity;improved;Individual;Investments;Location;Machine Learning;machine learning algorithm;machine learning model;machine learning prediction;Maps;Metadata;mild cognitive impairment;Modeling;Monitor;National Oceanic and Atmospheric Administration;novel;Optics;Outcome;Output;parent grant;Parents;Particulate Matter;Predisposition;Process;public health research;Readiness;remote sensing;repository;Reproducibility;Research;Research Personnel;response;Risk Estimate;Smoke;Source;spatiotemporal;Subgroup;System;Techniques;Temperature;temporal measurement;Testing;tool;Training;United States Environmental Protection Agency;United States National Aeronautics and Space Administration;Universities;weather variables;Wildfire;Work

PROJECT_TITLE: Short and long-term consequences of wildfires for Alzheimer's disease and related dementias

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: SYRACUSE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative Sexual minority women (SMW) are one of the highest-risk groups for posttraumatic stress disorder (PTSD), hazardous drinking (HD), and comorbid PTSD and HD (PTSD-HD) due to psychosocial stressors, including trauma, sexual identity-specific stigma, intersectional stigma, and persistent stress reactivity. Extant research is limited by a lack of studies on the temporal precedence of PTSD in HD development and maintenance, physiological stress reactivity to intersectional stigma and its role in elevating the risk of PTSD-HD, and the development of brief, tailored treatments for PTSD-HD among SMW. The proposed research aims to address these gaps by 1) examining prospective longitudinal associations between PTSD symptom severity and HD over 11 years; 2) assessing the acute effects of intersectional stigma exposure on alcohol craving and state PTSD symptoms through biological mechanisms; and 3) guided by ADAPT-ITT phases 1 and 2, conducting formative interviews with SMW and Community Advisory Board members to adapt an existing cognitive- behavioral therapy module focused on cognitive reappraisal into a single-session intervention to reduce stress reactivity, PTSD symptom severity, and alcohol craving within the context of cue reactivity paradigms in SMW.

PI_NAMEs: SCHEER, JILLIAN R (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Acute;addiction;Address;alcohol craving;Alcohols;Biological;biopsychosocial;brief intervention;Cognitive;cognitive reappraisal;Cognitive Therapy;community advisory board;comorbidity;cue reactivity;Cues;Development;Disparity;Distress;emotion regulation;Exposure to;Funding;Future;hazardous drinking;high risk population;improved;individualized medicine;Intervention;Interview;Link;Long-Term Effects;Maintenance;member;Minority;minority communities;minority stressor;Modeling;parent project;Phase;Physiological;pilot test;Post-Traumatic Stress Disorders;prospective;psychosocial stressors;Research;response;Risk;Role;Safety;Science;Self Medication;Severities;sexual identity;sexual minority women;social stigma;Stimulus;Stress;stress reactivity;stress reduction;Symptoms;Testing;Trauma;Variant;violence exposure

PROJECT_TITLE: Testing a Biopsychosocial Model of Violence Exposure, Minority Stressors, and Hazardous Drinking among Sexual Minority Women

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Depression;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention;Social Determinants of Health;Teenage Pregnancy;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE. As economically vulnerable adolescent girls transition into young adulthood, they are at increased risk of HIV infection, disruptions to cognitive development and poor mental health as risk-taking behaviors including sexual risks and substance use become more pronounced. The Suubi4Her-R2 study, building on the efficacious Suubi4Her project, aims to longitudinally assess the impact of economic empowerment and family strengthening interventions on HIV risk behaviors, cognitive and mental health outcomes, and the cognitive mechanisms of change in adolescent girls who previously participated in an economic empowerment and family strengthening program in rural Uganda. Findings from this large longitudinal dataset may contribute to the scientific knowledge on the potential value of investing modest economic resources in poor and vulnerable girls during early adolescence and how these resources may offer long-term protection against known HIV, cognitive and mental health risks, with potential replicability in other low-resource countries.

PI_NAMEs: NAKASUJJA, NOELINE ;SSEWAMALA, FRED M (contact);THAMES, APRIL D

PROGRAM_OFFICER_NAME: KAMATH, SUSANNAH M A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adolescence;Adolescent;adolescent brain development;adolescent mental health;adolescent woman;Adult;Affect;Africa South of the Sahara;aged;AIDS prevention;Alcohols;Area;arm;Behavior;Benchmarking;boys;Brain;Caring;Charge;Cognitive;cognitive development;cognitive function;Communities;community burden;cost;cost effectiveness;Cost-Benefit Analysis;Costs and Benefits;Country;Decision Making;depressive symptoms;design;Development;Discrimination;drug misuse;early adolescence;economic impact;Economics;Emotional;empowerment;Enrollment;evidence base;Family;family support;Feeling suicidal;Fees;Female Adolescents;Future;Gender;Generations;girls;Health;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV/AIDS;improved;Incentives;Income;Inequality;Informal Social Control;Intervention;Investments;Knowledge;Life Cycle Stages;Link;Long-Term Effects;longitudinal dataset;male;Mediating;Mental Depression;Mental Health;neural network;Outcome;Participant;peer;peer influence;Poverty;pre-exposure prophylaxis;Prevalence;Prevention program;programs;Randomized, Controlled Trials;Recommendation;Reporting;Research;Research Priority;Resources;retention rate;Rewards;Risk;Risk Behaviors;Risk Taking;Rural;Rural Community;Schools;Secondary Schools;Self Concept;Sex Behavior;sexual risk taking;skills;social situation;social stigma;substance use;Testing;theories;Uganda;United States National Institutes of Health;vulnerable adolescent;Woman;World Health Organization;young adult;young woman;Youth

PROJECT_TITLE: Suubi4HER Round 2: Examining the Long-term Impact of A Combination Intervention on HIV Prevention, Care and Mental Health for Adolescents and Young Women in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: COLUMBIA

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative Postpartum care and health disparities persist, especially in rural and racially marginalized communities in the Southern United States. Hospitals play an essential role in mitigating adverse maternal outcomes during the postpartum period as over 98% of childbirths occur at the hospital settings; yet, despite the increasingly worse postpartum health, maternal mental health, and perinatal substance use disorders, little is known on how hospital obstetric patient race/ethnicity mix, obstetric workforce care model, capacity, and birth volume would impact these outcomes. We propose to evaluate the effectiveness of these hospital attributes in reducing postpartum health and healthcare disparities in South Carolina to inform equitable and comprehensive intrapartum and postpartum care model at health care systems with hospital services.

PI_NAMEs: HUNG, PEIYIN  (contact);TUCKER, CURISA M

PROGRAM_OFFICER_NAME: CLARK, REBECCA L

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;adverse maternal outcomes;Age;antenatal;behavioral health;Birth;Black Populations;California;Caring;Characteristics;Childbirth;Chronic Disease;Clinical;Conceptions;cost;Data;Data Linkages;Death Rate;Discharge Plannings;Discipline of obstetrics;Disease;effectiveness evaluation;Emergency department visit;encryption;Equity;ethnic disparity;Ethnic Origin;experience;Family Physicians;Female of child bearing age;Florida;follow-up;Geography;Goals;Health;Health behavior;health care disparity;health care quality;Health Care Quality Indicators;health disparity;health inequalities;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;holistic approach;hospital readmission;hospital services;Hospitalization;Hospitals;improved;Individual;Inequity;innovation;Inpatients;Institutional Racism;Interdisciplinary Study;intersectionality;Intervention;intrapartum;Knowledge;Life;Link;Location;marginalized community;marginalized population;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Maternity Hospitals;Medicaid;Mental disorders;Mental Health;Modeling;mortality;Mothers;Neighborhoods;neonatal outcome;New York;Nurse Midwives;Oregon;Outcome;Outpatients;Pathway interactions;Patients;Pattern;Perinatal;Perinatal Care;perinatal mental health;perinatal period;Play;Policies;Population;population based;Population Heterogeneity;postpartum care;postpartum health;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Prenatal care;prevent;Probability;Psyche structure;Psychology;Race;racial disparity;racial diversity;readmission rates;Records;reproductive;Research;residence;Risk;Risk Factors;Role;Rural;rural area;Rural Community;rural disparities;rural dwellers;rural residence;rurality;screening, brief intervention, referral, and treatment;Signal Transduction;social determinants;sociodemographics;South Carolina;structural health determinants;Structural Racism;substance use;Substance Use Disorder;Surveys;Time;tv watching;Underrepresented Populations;Underserved Population;United States;urban area;Variant;Visit;Vital Statistics;Woman;Women's Health

PROJECT_TITLE: Hospital Variations in Postpartum Care Access, Quality, and Outcome: The Intersectionality of Residence Location and Race/Ethnicity


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Hematology;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: CHICAGO

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Through this application, our goal is to join efforts with the larger VCID (vascular contributions to cognitive impairment and dementia) initiative to advance fundamental understanding of how hyperlipidemia and atherosclerosis contribute to impaired brain vessels. We will determine whether correction of hyperlipidemia may delay AD progression or severity. In addition, the efforts put forward have the potential to identify biomarkers of disease progression contributed by components of the brain vasculature.

PI_NAMEs: IRUELA-ARISPE, M. LUISA  (contact);VASSAR, ROBERT J

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Abbreviations;Address;Affect;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;amyloid pathology;Amyloidosis;Atherosclerosis;atherosclerotic plaque rupture;Atlases;behavioral study;Biological Markers;biomarker identification;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;brain dysfunction;brain tissue;Cardiovascular Diseases;Carotid Arteries;catalyst;Cell Physiology;Cells;Cerebral Amyloid Angiopathy;Cerebral Infarction;cerebral microvasculature;cerebrovascular;Cerebrovascular system;Cholesterol;Circle of Willis;Clinical;comorbidity;Computational algorithm;Data;Defect;Dementia;density;Diabetes Mellitus;Diet;Disease;Disease Progression;Early Onset Alzheimer Disease;Embolism;Endoplasmic Reticulum;Endothelial Cells;Endothelium;Exhibits;experimental study;Extravasation;Fibrinogen;Functional disorder;Funding Opportunities;Genetic Transcription;glymphatic flow;Goals;Health;Hippocampus;holistic approach;Human;hypercholesterolemia;Hyperlipidemia;Hypertension;immunoregulation;Impaired cognition;Impairment;Infarction;Inflammatory;Informatics;insight;Intervention;Investigation;Knowledge;Late Onset Alzheimer Disease;Lesion;Link;Lipids;Low Density Lipoprotein Receptor;Macrophage;Metabolic;Microvascular Dysfunction;Modeling;Molecular;Molecular Profiling;mouse model;multiple datasets;multiple omics;Mus;Nerve Degeneration;neuroinflammation;Neurons;neurovascular;novel;old mice;Pathology;Pathway interactions;Patients;Pericytes;Permeability;Pharmaceutical Preparations;pharmacologic;Physiological;Predisposition;Prevalence;Process;Proteins;Proteomics;Research;Resolution;response;Senile Plaques;Serum;Severity of illness;single-cell RNA sequencing;Smooth Muscle;Smooth Muscle Myocytes;spatiotemporal;specific biomarkers;Specimen;Symptoms;System;Testing;Therapeutic;Thromboembolism;Thrombosis;Time;transcriptome;transcriptomics;vascular cognitive impairment and dementia;Vascular Diseases;western diet

PROJECT_TITLE: Vasculo-neuronal pathophysiological interface in Alzheimer’s and Atherosclerosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-M (21)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Misuse of opioid drugs and opioid overdose pose major public health concerns. Existing medications for opioid use disorder (OUD) are inadequate, as evidenced by the high rate of relapse to opioid seeking and opioid- associated deaths. Here, we propose to validate the neuropeptide receptor neurotensin receptor 1 (NTSR1) as a therapeutic target in OUD and to discover small molecule probes for this receptor that may serve as the basis for novel medications for relapse prevention.

PI_NAMEs: OLSON, STEVEN H;SLOSKY, LAUREN M (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Ablation;Abstinence;Acute;addiction;addiction liability;Address;Agonist;antagonist;Arrestin Beta 1;Attenuated;Behavior;beta-arrestin;Biological Assay;Brain;Brain region;Cells;Cessation of life;Characteristics;Chemicals;Chronic;Clinical;Cocaine;cocaine self-administration;Complex;Data;design;Development;Dopamine;Dopamine D2 Receptor;drug addict;drug development;drug discovery;drug misuse;efficacy study;efficacy testing;Epidemic;G alpha q Protein;G-Protein-Coupled Receptors;Generations;Genetic;Goals;GTP-Binding Proteins;Heterotrimeric GTP-Binding Proteins;high dimensionality;Hypotension;improved;in vivo;Individual;Interdisciplinary Study;Intravenous;Knockout Mice;Knowledge;lead optimization;lead series;Ligands;medication for opioid use disorder;meetings;mesolimbic system;Methamphetamine;Modeling;Monitor;Morphine;mouse model;Mus;natural hypothermia;Nature;Neuropeptide Receptor;Neurotensin Receptors;neurotensin type 1 receptor;new therapeutic target;next generation;Normalcy;novel;Opiate Addiction;Opioid;opioid injection;opioid misuse;opioid overdose;opioid use;opioid use disorder;Pathway interactions;Penetration;Permeability;permissiveness;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Physiological;prevent;Property;Proteins;psychostimulant;Public Health;receptor;Receptor Signaling;Records;Recovery;Relapse;relapse prevention;remifentanil;Research;response;Rewards;scaffold;Scheme;Scientist;screening;Self Administration;Series;side effect;Signal Transduction;Signaling Protein;small molecule;Solubility;Stimulant;stimulant use disorder;Structure;Structure-Activity Relationship;success;System;targeted treatment;Testing;Therapeutic;therapeutic target;Transducers;treatment strategy;Validation

PROJECT_TITLE: Neurotensin receptor 1 as a novel target for opioid use disorder and discovery of new small molecule probes

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 IXR-N (A2)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Depression begins in adolescence, occurs at high rates in sexual and gender minority (SGM) young people, and is related to impaired functioning and suicide. Understanding the mechanisms of depression in the developing brain will improve our ability to prevent and treat this pernicious disorder. To investigate the role of the dopamine system, which is altered in depression, and build on an ongoing study (R01 MH127014), we will add measures of SGM stress to the parent study and enroll additional participants who identify as SGM.

PI_NAMEs: FORBES, ERIKA E (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Administrative Supplement;Adolescence;Anhedonia;Behavior;Behavioral;Biological Assay;Blood;Brain;Brain Stem;Buffers;Cellular Phone;child depression;Clinical;clinical translation;Corpus striatum structure;depressive symptoms;design;Development;disability;Disease;Disparity;Dopamine;dopamine system;Ecological momentary assessment;Enrollment;experience;follow-up;Funding;gender minority;gender minority stress;gender minority youth;high risk;Impairment;improved;Inflammation;inflammatory marker;Influentials;Interleukin-6;Iron;Life;Life Experience;Magnetic Resonance Imaging;Measurement;Measures;Mediator;Mental Depression;Methods;minority children;Motivation;Motor Activity;Movement;neglect;neurobehavioral;neuromelanin;neuroregulation;Neurosciences;Parents;Participant;Pathway interactions;Persons;prevent;Procedures;protective factors;Psychopathology;reward circuitry;reward processing;Rewards;Role;Sampling;self-reported depression;sensor;Sexual and Gender Minorities;sexual minority;Stress;stressor;Suicide;Support System;System;Telephone;Time;Tissues;Visit;Work

PROJECT_TITLE: Dopamine Availability and Developmental Pathways of Adolescent Depression and Anhedonia - Administrative Supplement

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Women have historically been understudied and underrepresented in health research with negative and uneven consequences for their health and wellbeing. This supplement will support infrastructure at the Brown Population Studies and Training Center to build interdisciplinary teams of scientists with diverse expertise to advance population research on the health of women of understudied, underrepresented, and underreported populations.

PI_NAMEs: JACKSON, MARGOT  (contact)

PROJECT_TERMS: Area;Biology;Biomedical Research;career;Child;Collaborations;Communities;Creativeness;Data;Development;Dimensions;Disadvantaged;Discipline;Disease;Educational workshop;Environment;Faculty;Family;flexibility;Fostering;Foundations;Funding;Gender;Goals;Grant;Health;health disparity;health equity;Health equity research;health inequalities;Health Sciences;Healthcare;HIV/AIDS;Immigration;Individual;Inequality;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Investments;marginalized population;Medicine;Mentors;Methodology;Methods;migration;next generation;Paint;parent project;Pattern;Personal Satisfaction;Population;Population Dynamics;population health;Population Research;Population Sciences;Population Study;Portraits;Process;programs;Public Health;Reporting;Reproductive Health;Request for Applications;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Resources;response;Science;Scientist;Series;Services;sex;sex as a biological variable;sobriety;social;social determinants;social health determinants;Social Sciences;social structure;statistics;structural determinants;structural health determinants;Structure;Training;trend;United States;United States National Institutes of Health;Universities;Urbanization;Woman;Women's Health;working group


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Project Narrative Women infection, (MOUD) services and concepts and women involved in the carceral system are at an increased risk of opioid use disorder, overdose and HIV- but specific barriers to uptake of medications for HIV prevention (PrEP) and opioid use disorder exist, warranting a culturally adapted intervention tha could be integrated in existing navigation to after release from a carceral setting. Because little is known about how intersectional tigma, trauma, coping strategies such as resiliency impact this linkage, his administrative supplement will explore these in formative work (surveys with women and system providers, longitudinal i nterviews with women) findings will be embedded i n a web-based application called PA-Links which will be concept tested by with lived experience to ensure it meet the needs of this at-risk population. t s t

PI_NAMEs: BASS, SARAH B (contact);DAURIA, EMILY F

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: Address;Adherence;Administrative Supplement;Affect;AIDS prevention;Award;Bass;Clinical Trials;college;Communities;community advisory board;community partners;Complex;Coping Skills;cultural competence;culturally appropriate intervention;Development;Discipline;Disease;Drug usage;efficacy testing;eHealth;Ensure;Equity;experience;Funding;Future;girls;Goals;Health;Healthcare;High Risk Woman;HIV;HIV Infections;HIV risk;improved;Individual;Inequity;Infection;interest;Intervention;Interview;Investigation;Jail;Link;Lived experience;Measures;medication for opioid use disorder;member;Mobile Health Application;Online Systems;opioid use disorder;Overdose;overdose risk;parent project;Parents;Participant;patient navigation;Patients;Perception;Pharmaceutical Preparations;Philadelphia;pilot test;Population;Populations at Risk;pre-exposure prophylaxis;Prevention;prevention service;prospective;Provider;Public Health;Public Health Schools;Race;Research;resilience;response;Risk;Role;service delivery;service uptake;Services;Shapes;social stigma;Subgroup;Substance Use Disorder;substance use treatment;Surveys;System;Testing;Time;timeline;tool;Trauma;treatment services;Universities;uptake;usability;web app;web-based assessment;Woman;Women's Group;Women's Health;Work

PROJECT_TITLE: Development and pilot testing of a mobile health application to improve HIV prevention and substance use treatment service access among women involved in the carceral system

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Cost Effectiveness Research;HIV/AIDS;Health Services;Heart Disease;Hypertension;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The Kingdom of eSwatini has the world’s highest prevalence of HIV, but has become a world leader in HIV treatment and achieved dramatic declines in HIV mortality. In contrast, deaths from many non-communicable diseases (NCDs) in eSwatini are increasing, including the second-leading cause of death after HIV: cardiovascular disease. This project will examine the potential efficiency of HIV/NCD care integration over the future course of the HIV epidemic, identify optimal health benefits packages produce the greatest health benefits across major communicable and non-communicable diseases, and consider potential adjustments to health benefits due to the risk of future health systems disruptions such as pandemics, conflict, and natural disasters.

PI_NAMEs: BERSHTEYN, ANNA  (contact);REVILL, PAUL

PROGRAM_OFFICER_NAME: VITALIS, DEBBIE

PROJECT_TERMS: Achievement;Address;Adult;Africa South of the Sahara;African;aging related;AIDS prevention;Anti-Retroviral Agents;authority;Budgets;burden of illness;Calibration;Cardiovascular Diseases;cardiovascular disorder prevention;care systems;Caring;Cause of Death;Central Africa;Cessation of life;Chronic;Chronic Kidney Failure;climate change;Community Health;comparative;Conflict (Psychology);cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;Country;demographics;Diabetes Mellitus;Diagnosis;Disease;Eastern Africa;effective therapy;Epidemic;Event;experience;extend lifespan;Face;Future;General Population;Goals;Grant;Head;Health;Health Benefit;health care delivery;health data;health economics;Health Personnel;Health Policy;Health Services;Health system;Healthcare Systems;High Prevalence;high risk;HIV;HIV Infections;HIV/AIDS;Hypertension;hypertension control;improved;Incidence;Individual;Inflammation;Infrastructure;insight;interest;Interruption;Investments;Malignant Neoplasms;Modality;Modeling;Morbidity - disease rate;mortality;Natural Disasters;Older Population;Oral;pandemic disease;pandemic potential;parent grant;parent project;Parents;Persons;Pharmaceutical Preparations;Population Growth;population health;pre-exposure prophylaxis;Prevalence;Primary Prevention;Research;resilience;Resource Allocation;Resources;Risk;Risk Factors;Self-Injurious Behavior;Services;Shock;side effect;Source;Southern Africa;Time;trend;Variant;Violence;Viral Load result;Weight Gain;Work

PROJECT_TITLE: Leveraging HIV care systems to improve cardiovascular disease prevention in the Kingdom of eSwatini

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pregnancy;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Narrative Indigenous mothers have the highest rates of maternal mortality and morbidity in the U.S. The primary objective of this U54 application is to establish a successful and self-sustaining Center for Indigenous Resilience, Culture, and Maternal Health Equity (CIRCLE) to understand and intervene to improve Indigenous maternal health. We will collaborate and work closely with other Maternal Health Research Centers of Excellence, Implementation Science Hub, and Innovative Data and Coordination Hub to provide insights on root causes and translational opportunities with the long-term goal of reducing Indigenous maternal mortality and morbidity and promoting maternal health equity.

PI_NAMEs: FRIEDMAN, JACOB E;SHREFFLER, KARINA M. (contact);SPICER, PAUL G;VANWAGONER, TIMOTHY M

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Address;Alaska Native;American Indians;Amniotic Fluid Embolism;Anthropology;Autoimmune Diseases;Automobile Driving;base;Behavioral;biobehavior;Bioinformatics;Biological;Biometry;Birth;Blood Vessels;Cardiac;cardiometabolism;career;Centers of Research Excellence;Cessation of life;Chronic stress;Collaborations;Collagen;Communities;community based participatory research;community partners;community partnership;Conceptions;Continuity of Patient Care;Coronary;Country;cultural health;Data;Death Rate;Discipline of Nursing;Discipline of obstetrics;disparities in morbidity;disparity elimination;Ensure;Epidemiology;Equity;Ethics;experience;Family;Food;food insecurity;Foundations;Funding;Future;Goals;Gynecology;Health;health disparity;Health equity research;health inequalities;Health system;Hemorrhage;high risk;Homicide;Human Development;Immunology;implementation science;improved;Indigenous;indigenous community;Individual;Inequity;Infection;Injury;innovation;insight;intergenerational;Interruption;Intervention;intimate partner violence;Knowledge;Label;Leadership;Life;Maternal Health;Maternal health equity;maternal morbidity;Maternal Mortality;maternal outcome;maternal wellbeing;Maternal-fetal medicine;Medical;member;Mental Health;Mission;mortality;Mothers;Native Americans;Not Hispanic or Latino;Nursing Care Management;nutrition;Obesity;Oklahoma;Outcome;Outcomes Research;Pathway interactions;Patient-Focused Outcomes;Physiology;Population;postpartum care;Postpartum Period;Pregnancy;Pregnancy Outcome;pregnancy related death;prenatal;Process;Public Health;public health priorities;Race;Recommendation;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;Research Training;resilience;Resources;Role;Rural;Sampling;Self Care;severe maternal morbidity;social;Sociology;Source;Substance Use Disorder;Suicide;synergism;Testing;Translating;translational potential;Translational Research;Trauma;tribal community;tribal health;tribal leader;tribal member;tribal organization;Tribes;United States;United States National Institutes of Health;White Women;Woman;Women's Health;Work

PROJECT_TITLE: Building Data Capacity for Maternal Health Equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(71)-R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON MEDICAL CENTER

ORG_STATE: MA

PHR: NARRATIVE HIV infection is associated with dysregulated immune cell activities. We are proposing to explore how HIV RNA expression from defective proviruses mediate these inflammatory responses. These studies are relevant for understanding how HIV perpetuates disease even with antiretroviral treatments and could provide new targets and strategies for treatments to improve the lives of people living with HIV.

PI_NAMEs: GUMMULURU, SURYARAM ;HENDERSON, ANDREW J (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;antiretroviral therapy;Attenuated;Bypass;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cells;Chronic;Clinical;comorbidity;cytokine;Disease;Disease Progression;DNA;DNA Damage;DNA Repair;frailty;Generations;Genetic Transcription;Genome;HIV;HIV Infections;HIV Integrase;HIV-1;HIV-2;Immune;immune activation;Immune System Diseases;improved;In Vitro;Infection;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;innate immune function;innate immune sensing;insight;Introns;Lead;Macrophage;Mediating;Mononuclear;Mutation;Neurologic Deficit;novel;Organ;Outcome;Pathway interactions;Persons;prevent;Production;promoter;Proteins;Proviruses;response;Rest;Reverse Transcription;RNA;Role;Sampling;Testing;Transcript;treatment strategy;Viral;Viral Load result;viral RNA;Virion;Virus;vpr Gene Products

PROJECT_TITLE: Defective HIV proviruses and Persistent Innate Immune Activation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (02)]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Antiretroviral therapies save lives of millions of people living with HIV (PLWH). However, evolution of multi- drug-resistant viral phenotypes is a major clinical problem, and there are limited or no treatment options for heavily treatment-experienced PLWH. We will investigate the non-catalytic function of HIV-1 integrase during virion morphogenesis and target this essential, yet clinically unexploited step in viral replication by a novel class of investigational antiretroviral agents termed allosteric integrase inhibitors, which potently inhibit wild type and all drug-resistant HIV-1 phenotypes that have emerged so far.

PI_NAMEs: FUCHS, JAMES R;KUTLUAY, SEBLA B.;KVARATSKHELIA, MAMUKA  (contact);LYUMKIS, DMITRY

PROGRAM_OFFICER_NAME: PTAK, ROGER

PROJECT_TERMS: Address;Affinity;analog;Anti-Retroviral Agents;antiretroviral therapy;base;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Biology;Capsid;Chemicals;Clinical;clinical candidate;Complex;cost effective;crosslinking and immunoprecipitation sequencing;Cryoelectron Microscopy;Drug Industry;Drug resistance;drug resistant virus;Elements;Encapsulated;Evolution;Exhibits;experience;experimental study;Generations;Genome;Genomic Segment;Goals;Grant;HIV;HIV-1;HIV-1 drug resistance;HIV-1 integrase;Impairment;improved;In Vitro;in vitro Model;inhibitor;insight;Integrase;Integrase Inhibitors;interest;Investigation;Investigational Drugs;Knowledge;Laboratories;Lead;Life Cycle Stages;Mediating;Molecular Biology;Morphogenesis;Multi-Drug Resistance;multidisciplinary;Mutation;new therapeutic target;novel;novel therapeutics;particle;Peer Review;Persons;Pharmaceutical Chemistry;Phase II Clinical Trials;Phenotype;Play;preference;Publications;Recombinants;Research;Resistance;Ribonucleoproteins;RNA;Role;Scientist;Seminal;South Korea;structural biology;Structure;therapeutic target;Time;Viral;viral RNA;Virion;virology;Virus Replication;Virus-like particle;X-Ray Crystallography

PROJECT_TITLE: Role of HIV-1 integrase in virion morphogenesis and its targeting by allosteric integrase inhibitors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-X (03)]


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE The glymphatic-lymphatic system in the brain was recently discovered to play an essential role in immune surveillance and clearance of metabolic waste. Our proposed preclinical studies will provide preliminary evidence of biomarker validation and corresponding imaging findings in neurodegenerative diseases.

PI_NAMEs: DUNCAN, MELINDA K (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Administrative Supplement;Adopted;Affect;Affinity;Age;aged;alpha synuclein;animal imaging;aquaporin 4;Astrocytes;Attention;autism spectrum disorder;Autoradiography;Award;Binding;Biochemical Pathway;Biological;Biological Assay;Biological Markers;biomarker validation;blood-brain barrier penetration;Brain;brain control;Brain imaging;brain parenchyma;Brain region;C57BL/6 Mouse;Cell Cycle Progression;cell type;Centers of Research Excellence;Central Nervous System;Central Nervous System Diseases;Child;Clinical;Clinical assessments;clinical translation;Collaborations;Contrast Media;cost;Custom;Data;Delaware;Dementia;Dementia with Lewy Bodies;design;Development;Diagnosis;diagnostic development;disease model;dopaminergic neuron;driving force;drug development;Elderly;Eligibility Determination;Enzymes;Epilepsy;Flow Cytometry;fluorescence imaging;Fluorine;Foundations;Functional disorder;Functional Imaging;Funding;Future;Gadolinium;Glial Fibrillary Acidic Protein;glymphatic dysfunction;glymphatic function;glymphatic system;Goals;Image;imaging agent;imaging modality;Imaging Techniques;Imaging technology;immune clearance;Immunologic Surveillance;Impairment;improved;in vivo imaging;Individual;innovation;interdisciplinary collaboration;interest;Knowledge;Label;Ligands;lymphatic drainage;Lymphatic Endothelium;lymphatic vessel;Maintenance;Measures;Mediating;Meningeal lymphatic system;Meninges;Metabolic;metabolic profile;metabolic rate;Metabolism;Methodology;Microglia;Molecular;mouse model;Multiple Sclerosis;Mus;Musculoskeletal;Nerve Degeneration;nerve stem cell;Nervous System Disorder;Neurodegenerative Disorders;Neurons;neuropathology;Neurosciences;non-invasive imaging;nonhuman primate;novel;novel diagnostics;novel marker;overexpression;Parents;Parkinson Disease;Pathologic;Peptide Synthesis;Peptides;Phase;Phosphotransferases;Pilot Projects;Play;Population;Positron-Emission Tomography;pre-clinical;pre-formed fibril;preclinical study;Prosthesis;protein aggregation;Proteins;pup;Radioactive;Radiolabeled;radiotracer;real-time images;receptor;Receptor Protein-Tyrosine Kinases;Reporting;Research;Research Proposals;response;Rodent;Role;Sampling;Science;Scientist;Signal Transduction;Solid;Stroke;System;targeted biomarker;Testing;therapeutic development;Therapeutic Intervention;therapy development;Time;Tissues;Tracer;Traumatic Brain Injury;Tyrosine 3-Monooxygenase;Universities;Validation;Vascular Endothelial Cell;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;wasting;water channel

PROJECT_TITLE: Delaware INBRE


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Telehealth;Women's Health Research

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

PHR: NARRATIVE Postpartum depression is a significant public health concern, as at least 1 in 7 individuals will experience postpartum depression, yet alarmingly little is known about rates of postpartum depression and efficacious treatment among sexual and gender minority people. This project has clear relevance, affecting this significant mental health problem by determining whether an established preventive intervention (group interpersonal psychotherapy) benefits sexual and gender minority people similar to their cisgender, heterosexual counterparts. Recommendations based on this study will support an improved understanding of and prevention efforts for postpartum depression for pregnant sexual and gender minority people.

PI_NAMEs: DAVIS, ELYSIA POGGI;RHOADES, GALENA  (contact)

PROGRAM_OFFICER_NAME: CHU, SERENA PO-LAN

PROJECT_TERMS: Address;Administrative Supplement;Adult;Affect;African American;Alaska Native;American Indians;barrier to care;Basic Science;Black American;cisgender;Data;depression prevention;depressive symptoms;design;Developmental Delay Disorders;Diagnosis;Discrimination;efficacious treatment;Enrollment;Ensure;ethnic identity;ethnic minority population;Ethnic Origin;Evaluation;evidence base;experience;Gender Identity;gender minority;gender minority group;gender minority health;Goals;Hair;health disparity;health equity;health equity promotion;Healthcare;Heterosexuals;High Prevalence;Hispanic;Hospitals;Hydrocortisone;improved;indexing;Individual;interpersonal therapy;Intervention;intervention program;Interview;Knowledge;Latinx;Lesbian Gay Bisexual Transgender Queer;marginalization;marginalized population;Measures;Mediator;Mental Depression;Mental Health;Methods;minority stress;Modeling;Mothers;next generation;Parents;Participant;Patient Self-Report;perceived stress;Perception;Perinatal;perinatal complications;Persons;Physiological;Population;Postpartum Depression;pregnant;Premature Birth;prevent;Prevention;Prevention program;preventive intervention;primary outcome;Production;Program Accessibility;Program Effectiveness;programs;Psychopathology;Public Health;Qualifying;Race;racial minority population;randomized, clinical trials;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Project Grants;Risk;Risk Factors;Sampling;Science;secondary outcome;Services;Sex Orientation;Sexual and Gender Minorities;sexual minority group;Social support;Spanish/English;Stress;stressor;success;Testing;theories;Translating;Underserved Population;United States Preventative Services Task Force;virtual;virtual delivery

PROJECT_TITLE: Group-based Prevention of Postpartum Depression: In-person vs. Virtual Delivery


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Hematology;Hodgkin's Disease;Human Genome;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Rare Diseases

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Narrative Epstein-Barr virus (EBV) causes multiple types of lymphomas in people living with HIV/AIDS. These studies will increase understanding of how malignant EBV-infected cells evade natural killer cell immunosurveillance, which may lead to novel diagnostic and therapeutic approaches.

PI_NAMEs: GEWURZ, BENJAMIN ELISON (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Activated Natural Killer Cell;Adaptive Immune System;Adult;AIDS-Related Lymphoma;B lymphoid malignancy;B-Lymphocytes;Biochemical;Biological;Blocking Antibodies;Burkitt Lymphoma;Cadherin Domain;Cadherins;Cell Adhesion Molecules;Cell Line;cell transformation;Cells;Central Nervous System Lymphoma;Clustered Regularly Interspaced Short Palindromic Repeats;co-infection;Coculture Techniques;Complex;CRISPR screen;Cytolysis;Data;derepression;Epigenetic Process;Epstein-Barr Virus Infections;Epstein-Barr Virus latency;Epstein-Barr Virus-Related Lymphoma;Evolution;extracellular;Family member;Foundations;Frequencies;Future;Gamma counter;Gene Expression;Genes;genetic approach;genome-wide;Heterochromatin;HIV;HIV/AIDS;Hodgkin Disease;Human;Human Genome;Human Herpesvirus 4;Immune;Immunobiology;Immunocompetent;Immunologic Surveillance;Immunotherapeutic agent;in vivo;Incidence;Individual;infected B cell;inhibitor;Innate Immune System;insight;Integral Membrane Protein;killer inhibitory receptor;Knock-out;large cell Diffuse non-Hodgkin's lymphoma;Large-Cell Immunoblastic Lymphoma;Learning;loss of function;lymphoblastoid cell line;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Malignant - descriptor;Malignant Neoplasms;Modeling;mouse model;Natural Killer Cells;Neurons;novel;novel diagnostics;novel therapeutic intervention;Oncogenes;Oncogenic Viruses;Oncoproteins;Pathway interactions;Patients;Persons;post-transplant;prevent;Prevention approach;programs;Property;Publishing;receptor;Resistance;response;Role;Sampling;Signal Transduction;structural biology;T-Cell Depletion;T-Lymphocyte;Testing;Tissue Microarray;transcriptome sequencing;transforming virus;Transgenic Mice;tumor;Virus Latency

PROJECT_TITLE: Systematic CRISPR Analysis of EBV Lymphoma Resistance Pathways to Natural Killer Cell Lysis


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Infertility;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: Project narrative Inequities in the built environmental factors have been linked to inequities in our social environment, particularly for low income racially marginalized communities. This project will examine the direct effects of racial and economic segregation and the indirect effects of potential mediating neighborhood level built environmental factors on hypertensive disorders of pregnancy among Black women in the U.S. We hope this will increase our understanding of the interplay between the social and built environment to better inform population health interventions and outcomes related to maternal morbidity and mortality.

PI_NAMEs: WESSELINK, AMELIA KENT (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Adverse event;Air Pollution;Award;Black race;black women;built environment;career development;Complex;contextual factors;cost;Country;Dangerousness;Data Linkages;Death Rate;Development;Development Plans;Eclampsia;Economics;Environmental Exposure;Environmental Impact;Environmental Pollutants;Environmental Risk Factor;experience;Exposure to;Fertility;fetal;Food;Food Access;Goals;Green space;Health;health disparity;health disparity populations;health equity;health inequalities;high risk;Hypertension;Individual;Inequity;Infrastructure;Institution;interest;Intervention;Justice;Legal;Life Cycle Stages;Link;Literature;Low income;marginalization;marginalized community;marginalized population;Maternal complication;maternal hypertension;maternal morbidity;Maternal Mortality;maternal risk;Measurement;Measures;Mediating;Mediation;Mediator;Methods;mortality risk;Names;Neighborhoods;neonatal outcome;Noise;offspring;Outcome;parent grant;Participant;Pathway interactions;Persons;Police;Policies;Population;population health;postpartum morbidity;Pre-Eclampsia;preference;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnancy hypertension;Pregnancy Outcome;Premature Birth;primary outcome;Public Health;Race;racial disparity;reproductive;Reproductive Health;Research;research and development;residential segregation;Risk;Risk Factors;Role;secondary analysis;segregation;Shapes;social;Social Environment;Socioeconomic Factors;Stress;Structural Racism;subfertility;Toxic Environmental Substances;Translating;United States;Women's Health;Work

PROJECT_TITLE: An assessment of environmental and neighborhood-level risk factors for subfertility among Black women in the U.S.

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Lung;Orphan Drug;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative The proposed study is an administrative supplement that will train one PhD student from an underrepresented group. The research training plan examines the effect of a new surfactant treatment for ventilator induced lung injury. The student will gain expertise in animal models of lung injury, molecular biology, drug delivery, and formulation.

PI_NAMEs: LONGEST, P. WORTH  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Administrative Supplement;aerosolized;Aerosols;African American;Animal Model;Award;career;doctoral student;Drug Delivery Systems;Drug Industry;Dryness;Engineering;Enrollment;experience;Family;Female;Formulation;Goals;Health;Histology;Hypoxemia;Inflammasome;Inflammation;lung injury;marenostrin;Mentors;Modeling;Molecular Biology;novel therapeutics;Nucleotides;parent project;Patients;Pharmacologic Substance;Powder dose form;preclinical development;programs;Pulmonary Inflammation;Pulmonary Surfactants;Rattus;receptor;Research;Research Training;Role;skills;small molecule inhibitor;student mentoring;Students;surfactant;systemic inflammatory response;Testing;Therapeutic;Training;Underrepresented Populations;ventilation;Ventilator-induced lung injury;Work

PROJECT_TITLE: Preclinical development of a synthetic lung surfactant dry powder aerosol for hypoxemia or acute respiratory distress syndrome patients receiving different modes of ventilation support

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(82)-S]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: 8. Project Narrative Interpersonal or community violence is a long-standing health disparity that disproportionately affects African American youth, and suicide is disproportionately increasing among African American youth. This project evaluates the impact of a multisystemic prevention program designed to reduce health disparities in violence by promoting equity in African American youths’ experiences in education and law enforcement systems. This intervention has the potential to reduce morbidity and mortality among African American youth, promote overall quality of life, and reduce the societal costs associated with both interpersonal violence and suicidality.

PI_NAMEs: MEHARI, KRISTA RUTH (contact);SMITH, PHILLIP N

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Accounting;Address;Affect;African American;African American population;Age;aged;Aggressive behavior;Anxiety;archived data;assault;Attitude;base;Behavior;Behavior Therapy;caucasian American;Cause of Death;Cessation of life;Chronic;Cities;Climate;Communities;community building;community intervention;community violence;completed suicide;Data;depressive symptoms;design;Disadvantaged;Discipline;Distress;Education;educational atmosphere;Educational process of instructing;effective intervention;Effectiveness;Equity;Ethnic Origin;Evaluation;experience;Experimental Designs;Failure;Growth;health disparity;Homicide;Human Resources;ideation;Individual;Injury;innovation;Institutional Racism;Interpersonal Violence;Intervention;junior high school;Justice;juvenile arrest;Law Enforcement;Legal;Low income;male;Measures;Methodology;Minority;Morbidity - disease rate;mortality;multi-component intervention;novel strategies;Outcome;Patient Self-Report;pedagogy;perceived discrimination;Police;Police officer;Population;Prevalence;Prevention;Prevention approach;prevention practice;Prevention program;Prevention strategy;Prisons;Problem behavior;psychologic;Public Health;Quality of life;Race;racial disparity;racism;Randomized;Recording of previous events;Reduce health disparities;reduce youth violence;reducing suicide;Reporting;Research Personnel;Role;Safety;school violence;School-Age Population;Schools;Science;segregation;Self Direction;societal costs;stress symptom;stressor;Structural Racism;suicidal;Suicide;Suicide prevention;suicide rate;Surveys;Suspensions;System;systemic intervention;teacher;Training;trauma exposure;traumatic stress;Violence;violence exposure;violence prevention;Work;Youth;youth violence;youth violence prevention

PROJECT_TITLE: Preventing Youth Violence Through Building Equitable Communities: An Evaluation of a Multisystemic Intervention


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PI_NAMEs: CLAPPER, MARGIE L. (contact)

PROJECT_TERMS: Award;base;Biological Markers;Chemopreventive Agent;Clinic;Clinical Trials;Contracts;Development;drug development;efficacy evaluation;Malignant Neoplasms;meetings;Pharmacodynamics;pre-clinical;Preclinical Drug Development;preclinical efficacy;prevent;Preventive;Program Development;Regimen;Resources;Services;Structure;Support Contracts;vaccine development

PROJECT_TITLE: TO Title: Contract Orientation & Kickoff Meeting for Preclinical Services for PREVENT  Base IDIQ Title: PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate E


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PI_NAMEs: LIPKIN, STEVEN M (contact)

PROJECT_TERMS: Award;Biological Markers;Chemopreventive Agent;Clinic;Clinical Trials;Contracts;Development;drug development;efficacy evaluation;Malignant Neoplasms;meetings;Pharmacodynamics;Preclinical Drug Development;preclinical efficacy;Preventive;Program Development;Regimen;Resources;Services;Structure;Support Contracts;vaccine development

PROJECT_TITLE: Contract Orientation and Kickoff Meeting


ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PI_NAMEs: VILAR SANCHEZ, EDUARDO  (contact)

PROJECT_TERMS: Award;Biological Markers;Chemopreventive Agent;Clinic;Clinical Trials;Contracts;Development;drug development;efficacy evaluation;Malignant Neoplasms;meetings;Pharmacodynamics;pre-clinical;Preclinical Drug Development;preclinical efficacy;prevent;Preventive;Program Development;Regimen;Resources;Services;Structure;Support Contracts;vaccine development

PROJECT_TITLE: TO Title: Contract Orientation & Kickoff Meeting for Preclinical Services for PREVENTBase IDIQ Title: PREVENT Cancer Preclinical Drug Development Program: Preclinical Efficacy and Intermediate End


PI_NAMEs: RAO, CHINTHALAPALLY V. (contact)

PROJECT_TERMS: Award;Biological Markers;Chemopreventive Agent;Clinic;Clinical Trials;Contracts;Development;drug development;efficacy evaluation;Malignant Neoplasms;meetings;Pharmacodynamics;Preclinical Drug Development;preclinical efficacy;prevent;Preventive;Program Development;Regimen;Resources;Services;Structure;Support Contracts;vaccine development


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Biotechnology;Infectious Diseases;Osteoporosis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SANTA BARBARA

ORG_NAME: BIOVINC, LLC

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Bone fracture is a large medical problem in the US, with 6 million presentations each year, resulting in very large cost burdens. Some of these fractures do not heal properly, largely due to infections resulting in high additional costs and morbidity in this subset of patients. Novel strategies to support fracture healing in the context of delayed healing are urgently needed. A bone targeted antibiotic drug conjugate development approach is proposed to enhance fracture healing.

PI_NAMEs: EBETINO, FRANK H. (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Acids;Affect;Affinity;Aging;Amputation;analog;Animal Model;Animals;Anti-Bacterial Agents;Anti-Infective Agents;anti-microbial drug;Antibiotic Therapy;Antibiotics;appropriate dose;Bacteria;base;Biological;bisphosphonate;Blood Circulation;bone;bone fracture repair;Bone remodeling;Bone Resorption;Bone Surface;Carbamates;Caring;Cells;chemical release;Chemistry;clinical development;commercialization;cost;Data;design;Development;Disease;Dose;Drug Delivery Systems;Drug Kinetics;Drug Targeting;efficacy study;Ensure;Environment;Excretory function;Exposure to;Femur;first-in-human;Fluoroquinolones;Fracture;Goals;healing;Health system;Hour;Hydrolysis;Impaired healing;improved;improved outcome;in vivo;Incidence;Infection;infection rate;innovation;Intervention;Investigational New Drug Application;Lead;Length of Stay;liquid chromatography mass spectrometry;long bone;manufacture;Medical;Medical Care Costs;meetings;Metabolic;Methodology;Methods;Miniature Swine;Modeling;Morbidity - disease rate;mortality;novel;novel strategies;older patient;Open Fractures;Operative Surgical Procedures;opioid use;Osteoclasts;Osteomyelitis;Osteoporosis;Outcome;Parents;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;phase 2 study;Plasma;Polymorph;Population;pre-clinical;Preparation;prevent;Process;Production;productivity loss;Public Health;Quality of life;Reaction;Regimen;Relapse;Rodent Model;Safety;safety assessment;safety study;Sampling;scale up;screening;Series;Site;skeletal;Small Business Innovation Research Grant;Sodium Chloride;Solvents;Surgical Models;Techniques;Testing;Therapeutic;tibia;Toxicology;Trauma;Treatment outcome;United States Food and Drug Administration;urinary;Work

PROJECT_TITLE: A Novel Bone Targeted Antibiotic Therapy for the Treatment of Infected Fractures


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Mycobacterium avium is an environmental bacterium that is capable of infecting humans and causing serious disease, requiring months to years of antibiotic treatment to cure. This proposal aims to use novel genetic tools to identify the bacterial genes that allow some strains of M. avium to establish chronic infection, and the pathways that allow M. avium to tolerate prolonged antibiotic exposure once infection is established. In doing so, this work will provide fundamental insights into how environmental bacteria evolve into pathogens, and lay a foundation for the development of improved therapies for this and other chronic bacterial infections.

PI_NAMEs: CAREY, ALLISON  (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Acute;Address;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Bacteria;bacterial fitness;Bacterial Genes;Bacterial Genome;Bacterial Infections;Bar Codes;Biodiversity;Bioinformatics;Biological;Catalogs;Characteristics;Chronic;chronic infection;Clinical;clinically relevant;Communicable Diseases;comparative genomics;Creativeness;Data;design;Development;Diagnostic;Disease;disease phenotype;drug efficacy;Drug Exposure;emerging antimicrobial resistance;emerging pathogen;Environment;Experimental Genetics;experimental study;fitness;Foundations;Genes;Genetic;Genetic Determinism;Genetic Variation;genome wide association study;Genomic approach;Genomics;Genotype;Heterogeneity;Human;Impairment;improved;In Vitro;in vivo;Incidence;Infection;insight;interest;Link;Maps;Measurement;Methods;Microbe;microbial;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;mycobacterial;Mycobacterium avium;Mycobacterium tuberculosis;novel;novel strategies;Opportunistic Infections;Organism;pathogen;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;phenotypic data;Postdoctoral Fellow;Predisposition;programs;public health intervention;Research;response;skills;Techniques;Technology;Testing;Therapeutic;therapeutically effective;tool;trait;Treatment outcome;treatment response;Vaccination;vaccine efficacy;Vaccines;Virulence;Work

PROJECT_TITLE: Parallel phenotyping to dissect genetic determinants of bacterial strain diversity


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Digestive Diseases;Foodborne Illness

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE  This proposal describes synthetic routes to access various cyanopeptides. Synthesized compounds are used to evaluate their prevalence in natural waters, fish tissue, and aerosols and their bioactivity and toxicity are evaluated using in vitro fecal community and primary lung cell assays. The successful completion of this work will positively impact chemical, public health, and pharmaceutical research.

PI_NAMEs: AULT, ANDREW P;FRIBLEY, ANDREW MICHAEL;KODANKO, JEREMY ;WESTRICK, JUDY A (contact)

PROGRAM_OFFICER_NAME: DZIERLENGA, ANIKA LIN

PROJECT_TERMS: Aerosols;Agriculture;Area;Biology;Cells;Cellular Assay;Certification;Chemical Structure;Chemicals;Chemistry;climate change;Communities;contaminated seafood;Cyanobacterium;Cyanotoxin;design;drinking water;Ecology;empowerment;Environment;exposed human population;exposure route;Fishes;Food;Frequencies;Fresh Water;Gastrointestinal Diseases;Goals;Great Lakes Region;harmful algal blooms;Health;Human;hydrology;In Vitro;Ingestion;Inhalation;Investigation;Kidney Diseases;Liver diseases;Lung;Mass Spectrum Analysis;microcystin;Monitor;Nervous System Disorder;Pathway interactions;Peptides;Pharmacologic Substance;Pharmacology;Prevalence;public drinking;Public Health;reconstitution;Recreation;Reporting;Reproducibility;Research;Resources;Respiratory System;Risk;Route;Sewage;skin disorder;Source;stool sample;Tissues;Toxic effect;Toxicology;Toxin;Water;Work

PROJECT_TITLE: Synthesis and quantitation of microcystins and anabaenopeptins in the Great Lakes region to establish human exposure risks via ingestion and inhalation


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Primary Health Care;Social Determinants of Health

ORG_NAME: GOGYUP, INC.

PHR: PROJECT NARRATIVE Type 2 Diabetes Mellitus (T2DM) affects over 30 million Americans and requires patients to competently manage their conditions at home. However, the majority of diabetes self-management education (DSME) and aftercare print materials remain overly complicated, with excessively high reading difficulty and fall short in supporting functional readiness for self- management at home, especially for the 18% of U.S. adults unable to read beyond a second-grade level. This project will explore the potential for commercialization through the NIH I-Corps program.

PI_NAMEs: SHIPPEE, NATHAN D;ZIMMERMAN-BENCE, NED  (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: Adult;Affect;Aftercare;American;Caring;Chronic Disease;commercialization;Communication;Development;Diabetes Mellitus;diabetes self-management;digital;Education;Ensure;Environment;Funding;Health;health equity;health literacy;Home;Innovation Corps;Knowledge;Learning;Life;Limited English Proficiency;literacy;National Institute of Nursing Research;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Patient Education;Patients;Phase;Printing;Process;programs;Readiness;Reading;reading difficulties;Schools;second grade;Self Management;Services;Small Business Innovation Research Grant;Technology;Text;Training;United States National Institutes of Health;Visit;Workplace

PROJECT_TITLE: Increasing Health Equity Through In-The-Moment Reading Assistance for Adults with Diabetes Served at Community Health Centers


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: American Indian or Alaska Native;Clinical Research;Data Science;Diabetes;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Nutrition;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Diabetes and metabolic impairment are increasing worldwide and are associated with multiple complications, including nerve and kidney damage. The resulting symptoms severely impact quality of life in affected individuals. In this proposal, we aim to determine how long-term metabolic changes are associated with these complications, and if complications can be accurately predicted based on longitudinal metabolic measurements.

PI_NAMEs: REYNOLDS, EVAN L (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Affect;Age;Algorithms;American Indians;analytical tool;Body Weight decreased;Characteristics;Chronic Kidney Failure;Clinical Data;cohort;Complex;complex data;Complication;Complications of Diabetes Mellitus;Data;Data Scientist;Data Set;data warehouse;Databases;Development;Diabetes Mellitus;Diagnosis;Disease;Exercise;feature extraction;flexibility;Future;Goals;Health system;Heterogeneity;Impairment;improved;Incidence;Individual;innovation;Integrated Health Care Systems;Intervention;Knowledge;large scale data;large-scale database;Lead;life span;machine learning algorithm;machine learning prediction algorithm;Measurement;Medical;Mentors;Metabolic;Metabolic Control;Metabolic dysfunction;metabolic phenotype;metabolic profile;Metabolic syndrome;nerve damage;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Phase;Phenotype;Physiology;Pima Indian;Population;Populations at Risk;Prevalence;prevent;Quality of life;rate of change;renal damage;repository;Research Personnel;Risk;Risk Factors;Sample Size;Statistical Methods;Symptoms;Techniques;Testing;Time;Training;United States;United States Department of Veterans Affairs;Veterans;weight loss intervention

PROJECT_TITLE: Predicting complications of diabetes with longitudinal metabolic trajectories

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: Narrative Addiction to drugs of abuse, such as oxycodone, produces a myriad of negative effects and societal consequences. In understanding this disease, one long-standing question has been how to reduce opioid seeking and relapse behavior? Our goal is to demonstrate the utility of a novel class of molecules that when administered to rats mitigates drug seeking.

PI_NAMEs: CLARK, STEWART DONALDSON (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Abstinence;addiction;Address;Affect;Agonist;antagonist;Anti-Anxiety Agents;Arousal;Attenuated;Behavior;Behavioral;behavioral economics;Brain;brain circuitry;Cocaine;cocaine seeking;combat;Complex;Consumption;craving;Cues;Data;Development;Disease;Dose;drug discovery;drug of abuse;Drug usage;Drug Use Disorder;Eating;Equilibrium;experimental study;Family;Fasting;Female;Food;Future;Goals;Incubated;Individual;Intake;Interruption;Intervention;Intravenous;Knowledge;Ligands;male;Mediating;Modeling;Modification;Morphine;Motivation;Nature;neural circuit;neuromechanism;Neuropeptide Receptor;Neuropeptides;novel;Opioid;opioid exposure;opioid use disorder;opioid withdrawal;Oxycodone;oxycodone seeking;Pathway interactions;Patients;Penetrance;Peptides;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacological Treatment;Pre-Clinical Model;preclinical trial;Property;Protocols documentation;prototype;Rattus;receptor;Receptor Activation;receptor binding;receptor expression;Reinforcement Schedule;reinforcer;Relapse;Research;response;Rewards;Rodent;Role;Schedule;Secure;Self Administration;Signal Pathway;Signal Transduction;Societies;Substance of Abuse;Substance Use Disorder;Sucrose;Symptoms;System;Testing;Therapeutic;Transcript;Withdrawal;Work

PROJECT_TITLE: Preclinical Trial: Targeting the Neuropeptide S Receptor to Curb Opioid Taking and Seeking


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Our ELDERS supplement will expand our capacity to support recruitment and sustainability of anal cancer prevention among older SGM living with HIV in Nigeria. Recognizing the potential challenges to investments in infrastructure and training, and the need to maintain cost-effectiveness in resource-constrained settings, it is essential to work with the community to learn how to effectively recruit this highest risk yet hardest-to-reach group to improve engagement in anal cancer screening and improve outcomes. Ultimately, a better understanding of the context and perspectives of this community will advance the implementation of innovative cancer prevention strategies.

PI_NAMEs: ADEBAJO, SYLVIA ;NOWAK, REBECCA G. (contact)

PROGRAM_OFFICER_NAME: ALARO, JAMES R

PROJECT_TERMS: Acceleration;Address;Affect;Africa;Age;Age Years;cancer prevention;Clinic;cohort;Communities;Complement;Comprehension;Consolidated Framework for Implementation Research;cost effectiveness;Data;Decision Making;Detection;Development;Diagnosis;Enrollment;Ensure;experience;experimental study;Feedback;Future;gender minority community;Genetic Transcription;Goals;Guidelines;health knowledge;health seeking behavior;Health Services;Health Status;High Prevalence;high risk;high risk population;HIV;human old age (65+);implementation barriers;implementation research;improved;improved outcome;innovation;interest;Interview;intraepithelial;Investments;Language;Learning;Lesion;Location;male;Malignant neoplasm of anus;men;Methods;Modeling;mortality;Nigeria;Nigerian;Outcomes Research;preference;Prevalence;Prevention;Prevention program;Prevention strategy;Privacy;Process;Prognosis;Provider;Published Comment;Questionnaires;Randomized, Controlled Trials;recruit;Research;Resource-limited setting;Risk;screening;Screening for cancer;screening program;Sexual and Gender Minorities;socioeconomics;Structure;study population;success;Time;Training and Infrastructure;Work

PROJECT_TITLE: Engaging Leaders to Elicit Viewpoints on Anal Cancer Prevention (ELDERS) study


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: FARMINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE (as submitted in the original application) Transcriptional regulation of gene expression is central to complex biological processes, such as development, drug responses, and surviving cellular stress. Organisms must properly respond in a coordinated and stabilizing manner to a diversity of cues and insults. The goal of this work is to understand the mechanisms by which factors establish and maintain appropriate levels of gene transcription.

PI_NAMEs: GUERTIN, MICHAEL JOSEPH (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Biological Assay;Biological Process;Cellular Stress;Classification;cofactor;Complex;Computing Methodologies;Cues;Data;Development;Disease;Environmental Risk Factor;Estrogen Receptors;Estrogens;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;hormonal signals;Hormone use;ineffective therapies;Kinetics;Mediating;Modeling;Molecular;nutrition;Organism;Pharmaceutical Preparations;Process;programs;Regulation;Regulatory Element;Repression;Research;Resolution;response;Signal Transduction;Specificity;System;Testing;Time;tool;transcription factor;Transcriptional Regulation;Variant;Work

PROJECT_TITLE: Mechanisms of coordinate gene regulation by transcription factors


NIH_SPENDING_CATS: Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Wound Healing and Care

PHR: PROJECT NARRATIVE Wound healing is a major public health problem affecting millions of patients, and preliminary clinical and large animal data suggest that testosterone may impair wound repair while estrogen improves it, yet the mechanisms of these effects are poorly understood. In this project we will define the biology of how testosterone and estradiol act to change the wound immune environment and modulate the process of wound healing. This work will increase our understanding of biology in an understudied health disparity population and contribute new, fundamental knowledge of the sex hormone-tissue repair axis.

PI_NAMEs: O'BRIEN-COON, DEVIN  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acceleration;Affect;American;Androgen Receptor;animal data;Animals;behavior change;Biology;Caring;cell behavior;Cells;chronic wound;Cicatrix;Clinical;cost;cytokine;Environment;Estradiol;Estrogens;Evolution;Failure;gender affirming hormones;Gonadal Steroid Hormones;health disparity populations;Hormones;Hypertrophic Cicatrix;Immune;Immune response;immunoregulation;Impaired wound healing;Impairment;improved;In Vitro;in vitro Model;in vivo;innovation;interest;Knowledge;Link;male;marginalization;Mediating;men;Modeling;Molecular;non-healing wounds;novel;novel strategies;Pathway interactions;patient population;Patients;Ploidies;Population Growth;Process;programs;Public Health;Quality of life;regenerative repair;Research;response;Risk Factors;Rodent;sex;Sex Chromosomes;Sex Differences;System;Testosterone;Therapeutic;Time;tissue repair;Tissues;tool;transgender;Work;wound;wound care;wound healing

PROJECT_TITLE: Molecular Mechanisms of Hormone-Mediated Sex Differences in Wound Healing

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infertility;Maternal Health;Mental Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: Canton

ORG_NAME: HARVARD PILGRIM HEALTH CARE, INC.

PHR: PROJECT NARRATIVE Sexual minority women (SMW; e.g., lesbian, bisexual) are disproportionately burdened by adverse perinatal mental health relative to their heterosexual peers; this is especially concerning as adverse mental health is the most common perinatal health condition. Conception may be a time of increased emotional and financial dis- tress for SMW, particularly for those seeking care in fertility clinic settings; thus, this community-placed, mixed methods study will characterize the patient experience of fertility care and its impact on mental health among same-sex SMW and their partners in the U.S. Findings will inform development of best practices for inclusive family formation data collection and a subsequent community-based intervention grant to improve fertility ser- vice delivery and health outcomes for SMW and their children, responding to NIH calls for innovative strategies to address perinatal inequities among minoritized populations.

PI_NAMEs: CHARLTON, BRITTANY MICHELLE (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Address;Administrative Supplement;Affect;Articulation;assisted reproduction;Biological;Bisexual;care seeking;Caring;Child;child bearing;Child Health;Clinic;cohort;Cohort Studies;Communities;community intervention;Conceptions;cost;Couples;Data;Data Collection;Development;Discipline of obstetrics;Disparity;emotional distress;Evaluation;Exclusion;experience;extreme prematurity;Family;family genetics;Fertility;fertility improvement;Fertilization in Vitro;Financial Hardship;Future;Generations;Grant;Health;health disparity;health inequalities;Health Services Accessibility;Heterosexuals;improved;Inequity;innovation;intergenerational;Intervention;Interview;intrauterine insemination;Investigation;Knowledge;Lesbian;Lesbian Gay Bisexual;Libido;Low Birth Weight Infant;Maps;Measures;Mediator;Medical;Mental Depression;Mental disorders;Mental Health;Mental health promotion;Methodology;Methods;Minority Groups;minority stress;Modeling;neglect;Nurses' Health Study;obstetric outcomes;offspring;Outcome;parent project;Parents;patient engagement;Patients;peer;Perinatal;perinatal health;perinatal mental health;perinatal outcomes;perinatal period;Population;population based;Pregnancy;Process;prospective;Prospective Studies;Provider;Recommendation;Recording of previous events;Reporting;Research;Risk Factors;Role;Safety;same sex behavior;Same-sex;same-sex partnership;Sample Size;Sampling;Science;service delivery;Service delivery model;Services;Sex Orientation;sexual identity;sexual minority;sexual minority group;sexual minority women;social;sperm cell;Spontaneous abortion;stillbirth;Structure;substance use;Suggestion;Surveys;theories;Time;timeline;Training;United States National Institutes of Health;Visual;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Improving service delivery models of medically assisted reproduction: A patient journey mapping study of sexual minority women couples’ experience of medicalized family formation

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Most biologists believe that the mammalian heart has a very limited capacity to regenerate, one that is generally not sufficient to sustain functional recovery after a heart attack. Our recent work challenged this principle and instead argued that heart regeneration is variable trait, like height or eye color, with some individuals capable of meaningful repair and others not. The focus of this project is to identify the genes responsible for why some individuals are better at regenerating their hearts than others, the knowledge of which will help us better understand the mechanisms of heart regeneration and design therapeutics to stimulate the process across all patients.

PI_NAMEs: PATTERSON, MICHAELA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Ablation;Address;Adult;Affect;Animal Model;Belief;Birth;Candidate Disease Gene;candidate identification;Cardiac Myocytes;cardiac regeneration;Cardiovascular system;Cell Cycle;cell regeneration;Cells;Chromosomes;Classification;Clinical;combinatorial;Competence;Complex;Cytokinesis;Data;design;Diploidy;DNA biosynthesis;Evaluation;Eye Color;Failure;Frequencies;gene function;Genes;Genetic;genetic approach;Genetic Epistasis;genome wide association study;genomic locus;HDAC7 histone deacetylase;Heart;heart function;Heart Injuries;Height;Impairment;Individual;Infarction;Injury;innovation;Intervention;Knock-out;Knockout Mice;Knowledge;Laboratories;loss of function;Mediating;Mononuclear;Mouse Strains;Mus;Myocardial;Myocardial Infarction;Myocardial tissue;Myocardium;Natural regeneration;Nature;novel;Other Genetics;Outcome;overexpression;Patients;permissiveness;Phase;Phenotype;Phosphotransferases;Play;Ploidies;Polyploidy;Postdoctoral Fellow;postmitotic;postnatal;Process;Proliferating;Proteins;Recovery of Function;regenerative;Regenerative response;repaired;RNA;Role;Seminal;senescence;Testing;Therapeutic;trait;Variant;Work;Zebrafish

PROJECT_TITLE: Genetic interactions and multifactorial genetics mediate myocardial regeneration

STUDY_SECTION: MIM

STUDY_SECTION_NAME: Myocardial Ischemia and Metabolism Study Section[MIM]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Physical Activity;Prevention;Sleep Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The dysregulation of the circadian rhythm of blood pressure has a strong relationship with adverse cardiovascular outcomes, thus necessitating a need to identify modifiable behaviors that can be targeted for intervention to augment and/or preserve healthy circadian rhythms in 24-hour blood pressure. To address this need, this study will use state of the art measures and analytic procedures to evaluate the relationship between the 24-h activity cycle and 24-hour blood pressure. Findings of this study will elucidate the role of waking and sleep behaviors and their collective combinations over a 24-hour day on 24-hour blood pressure; information critical for establishing quantitative behavioral targets for achieving optimal 24-hour blood pressure.

PI_NAMEs: CHEUNG, KEN ;DIAZ, KEITH M (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Accelerometer;Activity Cycles;Address;Administrative Supplement;Adult;Ambulatory Blood Pressure Monitoring;Applications Grants;Area;aspirate;Behavioral;Blood Pressure;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;career development;Circadian Dysregulation;Circadian Rhythms;Clinical;Data;design;Devices;Dose;Dropout;Education;Epidemiology;epidemiology study;Exercise;Exercise Physiology;Funding;Future;Goals;Hour;Infrastructure;Intervention;Laboratories;Measures;Mentors;Methods;modifiable behavior;multidisciplinary;Outcome;parent grant;Participant;participant enrollment;Phase;Physical activity;Postdoctoral Fellow;preservation;Prevention;Prevention Research;Procedures;Productivity;programs;Protocols documentation;Randomized;Research;Research Activity;research data dissemination;Research Design;Research Methodology;Research Personnel;Research Project Grants;responsible research conduct;Role;Science;screening;sedentary;Sleep;sleep behavior;statistics;Testing;Time;Training;Visit

PROJECT_TITLE: Relationship between the 24-Hour Activity Cycle and 24-Hour Blood Pressure (PDS administrative supplement to R01HL153642)

STUDY_SECTION: BMIO

STUDY_SECTION_NAME: Behavioral Medicine, Interventions and Outcomes Study Section[BMIO]


NIH_SPENDING_CATS: Cancer;HIV/AIDS;Hematology;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Narrative EBV is the etiological agent of several malignancies including Hodgkin lymphoma (HL), and multiple types of non-Hodgkin lymphoma (NHL) including post-transplant lymphoproliferative disease (PTLD), diffuse large B cell lymphomas (DLBCL), T cell lymphomas, NK/T cell lymphoma (NKTL), and Burkitt's lymphoma (BL). There is an increased incidence of EBV-associated NHL in HIV-infected patients. In this proposal, we aim to explore the role of a cell cycle kinase as a novel therapeutic target for EBV-driven NHL.

PI_NAMEs: DAMANIA, BLOSSOM A (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: ABCB1 gene;aerobic glycolysis;Animal Model;ATP-Binding Cassette Transporters;B-Lymphocytes;beta catenin;Burkitt Lymphoma;carcinogenesis;Carrier Proteins;Cell Cycle;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Centrosome;Chemicals;Chemoresistance;chemotherapy;Clinical Trials;Data;Development;DNA biosynthesis;Drug resistance;Epstein-Barr pathogenesis;Epstein-Barr Virus Infections;Epstein-Barr Virus-Related Lymphoma;Etiology;Event;Frequencies;Gene Expression;Growth;Hematopoietic Neoplasms;high risk;HIV;HIV Infections;HIV Seropositivity;Hodgkin Disease;Human;Human Herpesvirus 4;humanized mouse;Impairment;In Vitro;in vivo;Incidence;Individual;inhibitor;kinase inhibitor;large cell Diffuse non-Hodgkin's lymphoma;lifetime risk;LMP1;Lymphoma;Lymphoma cell;Lymphomagenesis;Lymphoproliferative Disorders;Maintenance;Malignant Neoplasms;malignant stomach neoplasm;Modeling;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;Names;Nasopharynx Carcinoma;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel therapeutics;pathogen;Pathology;Patients;Phosphotransferases;Play;Population;post-transplant;prevent;Proliferating;Resistance;Role;T-Cell Lymphoma;Testing;Therapeutic;Transplant Recipients;tumor;Tumor Burden;tumor growth;Up-Regulation;Viral Genes;Virus;Work

PROJECT_TITLE: Therapy for Non-Hodgkin lympoma

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative No changes to Project Narrative from the parent award.

PI_NAMEs: NAUGHTON, MICHELLE J.;PARTRIDGE, ANN H (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: Academic Medical Centers;Adolescent and Young Adult;Affect;Anxiety;Biological;Biological Assay;Biological Factors;Biological Markers;Biology;Blood;Breast Cancer Patient;Breast Cancer survivor;cancer recurrence;Cancer Survivor;Characteristics;Collection;cytokine;Dana-Farber Cancer Institute;design;Diagnosis;disparity reduction;Dryness;Educational Intervention;efficacy testing;empowerment;ethnic diversity;Ethnic Origin;Fatigue;Gene Expression;Geography;Health;health disparity;improved;Income;indexing;Inflammation;Inflammatory;Intervention;Life Style;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Mental Depression;mhealth interventions;mindfulness meditation;Modeling;Monitor;Neurosecretory Systems;Ohio;older women;Online Systems;Operative Surgical Procedures;Outcome;parent grant;parent project;Participant;Patient-Focused Outcomes;Patients;peer;Periodicals;Personal Satisfaction;Production;Prognosis;Psychological Stress;psychosocial;psychosocial outcome;Quality of life;Race;racial diversity;racial minority;Randomized;Randomized, Controlled Trials;reduce symptoms;Reporting;Research;response;Rural Community;Sampling;Self Management;Sex Orientation;social deprivation;social factors;social health determinants;Social support;socioeconomics;Spottings;Stress;Subgroup;Supportive care;Survivors;Sympathetic Nervous System;symptomatology;Symptoms;systemic inflammatory response;treatment as usual;Treatment Protocols;Underrepresented Populations;Universities;web portal;Woman;women's diagnosis;young woman

PROJECT_TITLE: A web-based patient-reported symptom monitoring and self-management portal for adolescent and young adult breast cancer survivors


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Telehealth

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Meth use is an established and persistent driver of HIV incidence for MSM, with up to 33% of incident HIV infections in MSM attributable to stimulant use. There is increasing interest in delivering HIV prevention interventions via a mobile health (mHealth) platform, while implementing PrEP,3 to replicate the successes of mHealth delivery among meth-using MSM living with HIV. We seek to address this gap by evaluating the combination of state-of-the-art, multi-modal pharmaco-behavioral interventions for the greatest improvement in PrEP adherence, combining two mobile health technologies (PREPAPP with virtual cognitive behavioral therapy [CBT4CBT]), aiming to: (1) Evaluate the feasibility and acceptability of CHAMPION, compared to a waitlist control, and (2) Evaluate the preliminary efficacy of CHAMPION on increasing PrEP adherence, compared to a waitlist control.

PI_NAMEs: SANTOS, GLENN-MILO ;TSUYUKI, KIYOMI  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;AIDS prevention;Behavior;Behavior assessment;Behavior Therapy;Behavioral;behavioral pharmacology;Blood;care delivery;Caring;Cognitive Therapy;Computers;Coping Behavior;cost;Counseling;Data;Dose;Dryness;effective intervention;eligible participant;Emotions;Enrollment;follow-up;Future;Geography;Health Services Accessibility;Health Technology;high risk;HIV;HIV Infections;HIV risk;HIV Seronegativity;improved;Incidence;Individual;interest;Intervention;intervention effect;Link;Measures;men who have sex with men;Methamphetamine;Methamphetamine prevention;methamphetamine use;Methamphetamine use disorder;mHealth;Mobile Health Application;Modality;Monitor;multimodality;National Institute of Drug Abuse;Outcome;outcome disparities;participant enrollment;Pattern;Pharmaceutical Preparations;pilot test;Population;pre-exposure prophylaxis;Prevention;preventive intervention;primary outcome;Randomized;Randomized, Controlled Trials;Research;Risk;Risk Behaviors;Sampling;Sex Behavior;sexual risk behavior;Spottings;Stimulant;stimulant use;stress management;Structure;success;synergism;Technology;Testing;Time;transmission process;Transportation;treatment as usual;treatment choice;Viral Load result;virtual;Waiting Lists

PROJECT_TITLE: CHAMPION - Combining HIV And Stimulant Prevention and Treatment Interventions Optimized for HIV-Negative MSM

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CCHI-K (02)]