NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Anxious smokers account for a greater proportion of tobacco-related disease, underscoring the need to identify common mechanisms of anxiety-smoking risk. This application proposes four training goals and three research aims to launch a unique line of research that integrates best-practices in mechanism-focused addiction research, translational learning models of anxiety pathology, and psychophysiological data collection and analysis. The goal is to refine knowledge of physiological processes that underlie anxiety pathology, maintain smoking behavior, and promote their high comorbidity.

PI_NAMEs: BRINKMAN, HANNAH  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: addiction;Address;Adult;Affect;Analysis of Variance;Anatomy;Animal Experimentation;Animals;Anxiety;anxiety symptoms;anxious;Award;Back;Baroreflex;Behavior;Behavioral;behavioral response;Blood Pressure;Brain;Brain region;Caliber;Cardiovascular Physiology;Cardiovascular system;Central Nervous System;Chronic;Cigarette Smoker;cigarette smoking;Cognitive;Collection;Communication;comorbidity;conditioned fear;Cues;Data;Data Analyses;Data Collection;design;Development;disability;Disease;Emotional;Ensure;Etiology;Exhibits;experience;experimental study;Extinction;Feedback;Fellowship;Foundations;Fright;Future;Galvanic Skin Response;Goals;Health;Health behavior;Heart;Heart Rate;High Prevalence;Human;human model;Impairment;improved;improved outcome;indexing;insight;Intervention;Knowledge;Laboratories;Learning;Linear Regressions;Measures;Mediation;Methods;Modeling;neural;Nicotine;nicotine use;non-smoker;Outcome;Participant;Pathologic;Pathology;Peripheral;Peripheral Nervous System;Persons;Phase;Physiological;Physiological Processes;Positioning Attribute;Process;Psychophysiology;Public Health;Research;Research Design;Respiratory physiology;response;Risk;Risk Factors;Role;Science;Seminal;Signal Transduction;Smoker;Smoking;Smoking Behavior;smoking prevalence;Smoking Status;substance use;success;teaching assistant;Time;Tobacco;Training;Translating;translational model;Visceral;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Smoking-related Differences in Baroreflex Sensitivity and Fear Inhibition in Adults Who Do and Do Not Smoke Cigarettes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Uterine cancer is the most common gynecologic malignancy and exhibits one of the largest racial disparities in mortality risk among all cancer types. Evidence shows that black women are significantly more likely than white women to be diagnosed at advanced stage of uterine cancer which explains more of the racial gap in mortality risk than any other factor, yet there has been a major void in our knowledge regarding reasons for this disparity in stage at diagnosis. By rigorously examining three unique healthcare databases and conducting a novel population-based patient survey with linked cancer registry data, this study seeks to understand how various clinical, behavioral, sociocultural, and healthcare system factors in the diagnostic pathway may contribute to black-white disparity in early diagnosis of uterine cancer and to inform target areas for future interventions to address this health inequity.

PI_NAMEs: WRIGHT, JASON ;XU, XIAO  (contact)

PROGRAM_OFFICER_NAME: PADGETT, LYNNE SLAUGHTER

PROJECT_TERMS: Accounting;Address;Affect;Area;Awareness;Behavior;Behavioral;Belief;beneficiary;Black Populations;Black race;black women;black/white disparity;Cancer Death Rates;cancer diagnosis;Cancer Patient;cancer type;Cancerous;Caring;caucasian American;Characteristics;Clinical;Clinical Data;Collaborations;Data;Data Mart;data registry;Databases;design;Diagnosis;Diagnostic;Diagnostic Procedure;Diagnostic tests;disparities in women;Disparity;Disparity in diagnosis;disparity reduction;Early Diagnosis;Effectiveness;Ethnic Origin;Evaluation;evidence base;Exhibits;experience;follow-up;Future;Guidelines;Health Care Seeking Behavior;health inequalities;Health Services Accessibility;Healthcare;Healthcare Systems;high risk;Histologic;improved;Incidence;Infrastructure;Intervention;Knowledge;Link;Malignant Female Reproductive System Neoplasm;Malignant Neoplasms;Medicaid;Medicare;mortality disparity;mortality risk;neglect;neoplasm registry;Newly Diagnosed;novel;Obesity;Outcome;Pathology;Pathway interactions;patient population;patient prognosis;Patients;population based;Prevalence;Process;Prognostic Factor;Provider;Race;racial disparity;Recommendation;Reporting;Research;Risk Factors;Role;Sampling;Secondary Prevention;SEER Program;social culture;Socioeconomic Factors;Socioeconomic Status;socioeconomics;Stage at Diagnosis;Surveys;Symptoms;Technology;Testing;Time;tumor;Uterine Cancer;Uterine hemorrhage;White Women;Woman;women's diagnosis

PROJECT_TITLE: Racial Disparity in Diagnostic Evaluation of Uterine Cancer

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative RNA-targeting chemistries are the foundation for new classes of therapeutics that circumvent challenges associated with protein-centered drug discovery. Numerous cellular RNAs contain functionally-important tertiary structures that may specifically engage small molecules, yet there is currently no scalable platform for identification of these sites or small molecules that specifically engage these sites. The goal of this training and research proposal is to train the applicant in and allow the applicant to create a screening and bioinformatic platform for high-throughput discovery of covalent chemistries that modulate function of human RNAs.

PI_NAMEs: KHITUN, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;adduct;Affect;Bar Codes;Binding;Binding Sites;Bioinformatics;bioinformatics pipeline;Biological;Biological Process;biological systems;Biology;career;Categories;Cells;Chemicals;Chemistry;Complex;computational chemistry;computer science;Degradation Pathway;Derivation procedure;design;drug development;drug discovery;drug-like compound;druggable target;experience;experimental study;Fluorescent Probes;Foundations;Gene Expression;Goals;Guanine;Health;Human;innovation;Libraries;Ligand Binding;Ligands;Link;Location;Mass Spectrum Analysis;Mechlorethamine;Messenger RNA;Modification;Molecular;Molecular Biology;mRNA Stability;multidisciplinary;new technology;novel;Nucleotides;Oligonucleotides;Open Reading Frames;Organic Chemistry;Positioning Attribute;protein function;Proteins;Proteomics;Quality Control;rational design;Reaction;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;Resolution;Reverse Transcription;Ribosomes;RNA;RNA Binding;RNA library;RNA Sequences;RNA-targeting therapy;Role;scaffold;screening;Site;skills;small molecule;small molecule libraries;Structure;System;T47D;targeted treatment;Technology;technology development;technology platform;Therapeutic;therapeutic development;therapeutic target;Training;training project;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;Work

PROJECT_TITLE: Control of gene expression via RNA-targeted covalent probes


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE  We propose to conduct a well-powered social epigenomics study to investigate individual and social contextual factors in relation to DNA methylation, biological age, and lung cancer risk in a cohort of African Americans and European Americans at an elevated lung cancer risk. Our results will help us to better understand the mechanistic relationships between individual and neighborhood socioeconomic factors and lung cancer risk. The findings may provide useful information that could be used to ameliorate the lung cancer disparities.

PI_NAMEs: CAI, QIUYIN  (contact);LONG, JIRONG

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Acceleration;Adult;Affect;African American population;Age;age acceleration;American;Bioinformatics;Biological;biological age;Biological Aging;Biological Assay;Biological Markers;Blood;Blood specimen;Cancer Etiology;cancer health disparity;cancer risk;Cell Physiology;Cessation of life;Cigarette;cigarette smoking;cohort;Cohort Studies;Communities;contextual factors;cost efficient;Data;deprivation;Diagnostic;Disparity population;DNA;DNA Methylation;Early Diagnosis;Eating;Economically Deprived Population;Education;Environmental Exposure;Environmental Risk Factor;epidemiologic data;Epigenetic Process;epigenomics;Ethnic Population;European;Funding;Gene Expression;Genes;genome wide methylation;genome-wide;Goals;Health;Healthy Eating;high risk;Histologic;Household;In Vitro;Income;indexing;Individual;innovation;insight;Investigation;Life Style;lifestyle factors;Link;low socioeconomic status;lung cancer screening;male;Malignant neoplasm of lung;men;Mental Depression;Methylation;methylation biomarker;methylation pattern;Modification;Molecular;Neighborhoods;Not Hispanic or Latino;Occupational Status;Parents;Participant;Pathway interactions;Patient Self-Report;Play;Population;prospective;Race;racial disparity;racial minority;racial population;Reporting;Resources;Risk;Risk Factors;Role;Sampling;Site;Smoking;Smoking and Health Research;social;Social Environment;social factors;Social support;socioeconomic disadvantage;socioeconomic disparity;Socioeconomic Factors;Socioeconomic Status;Stress;Testing;Time;Woman

PROJECT_TITLE: Individual and social contextual factors in relation to DNA methylation, biological aging, and lung cancer risk


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Cells directionally migrate by protruding structures which are supported by the actin cytoskeleton and adhesion sites within the leading edge. To understand the biology of cell motility, an actin modifying protein called the mammalian diaphanous-related formin 1 (mDia1) that is switched on/off by the upstream p21 Rho family of small GTPase (RhoGTPase), is important in coordinating cell motility. Here, we will develop a near-infrared mDia1 biosensor to enable multiplex, simultaneous analysis of mDia1 activity together with a RhoGTPase biosensor in living cells and to study their dynamic functions during cellular leading edge protrusion formations.

PI_NAMEs: RAMIREZ, ANDREA  (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Actins;Adhesions;Binding;Biosensor;cell motility;Cell Physiology;Cells;Cellular biology;Cellular Structures;citrate carrier;Cytoskeleton;Data;Detection;Development;directional cell;Disease;Event;F-Actin;Family;Fluorescence Resonance Energy Transfer;Focal Adhesions;genetic manipulation;Goals;Guanine Nucleotide Exchange Factors;Immune;improved;Invaded;Knowledge;Malignant Neoplasms;Mechanics;Mediating;member;Membrane;Microfilaments;migration;Molecular Conformation;Molecular Mechanisms of Action;Monomeric GTP-Binding Proteins;Motility;mutant;novel therapeutic intervention;optogenetics;paralogous gene;Pathway interactions;Play;polymerization;Polymers;protein expression;Protein Isoforms;Protein Tyrosine Kinase;Proteins;recruit;red fluorescent protein;Regulation;Reporting;rho;rho GTP-Binding Proteins;Role;SH3 Domains;Signal Pathway;Signal Transduction;Site;spatiotemporal;Structure;Testing;Time;tool;Vav guanine-nucleotide exchange factor;Visualization;wound healing

PROJECT_TITLE: The Role of Mammalian Diaphanous Formin 1 in Leading Edge Cell Protrusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


NIH_SPENDING_CATS: Complementary and Integrative Health;Natural Products

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The proposed research seeks to impact human health by enabling the synthesis of tropolone natural products and derivatives thereof. Specifically, a sustainable and scalable platform for reaching useful tropolone cores will be developed to provide access to understudied bioactive tropolone natural products. Directed evolution strategies will be used to engineer biocatalysts to have improved physical properties and to possess the substrate scope to enable access to privileged natural product scaffolds. The development of this platform will allow for deeper studies of these valuable molecules which in turn will result in further understanding of natural products and their applications as therapeutics for human diseases.

PI_NAMEs: HERNANDEZ-MELENDEZ, JOSE R. (contact)

PROJECT_TITLE: Sustainable biocatalytic generation of bioactive tropolone natural products


ADMINISTERING_IC: AI

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Narrative The SARS-CoV-2 pandemic underscores the paramount threat that infectious diseases are to public health in the 21st century. The Infectious Diseases Training Program prepares predoctoral and physician-scientist fellows to investigate and respond to microbes that are new and ongoing threats to human health.

PI_NAMEs: CRISS, ALISON K;PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: SASTALLA, INKA I

PROJECT_TERMS: Communicable Diseases;Training Programs

PROJECT_TITLE: Infectious Diseases Training Program

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Genetics

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative  Sexually reproducing organisms rely on meiosis, a specialized cell division that generates haploid gametes, for genome inheritance from parent to offspring. Misregulation of this process results in gametes with an incorrect number of chromosomes, the primary cause of age-related infertility, miscarriage, and developmental disorders such as Down Syndrome. My proposed research will address the regulatory mechanisms that ensure faithful transmission of genetic information, informing the design of therapeutic interventions in human reproduction.

PI_NAMEs: GOLD, ARIEL LARISSA (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affinity;age related;Aneuploidy;Biochemical;Biological;C-terminal;Caenorhabditis elegans;Cell Cycle;Cell division;Chemicals;Chromosome Pairing;Chromosome Segregation;Chromosomes;Communication;Consensus;Data;design;developmental disease;Diploid Cells;Disease;Down's Syndrome;Ensure;Event;Failure;Family;Fluorescence Recovery After Photobleaching;Generations;Genetic;Genetic Crossing Over;genetic information;Genome;Germ Cells;Haploidy;Homologous Gene;Human;Image;Immunofluorescence Immunologic;in vivo;Infertility;insight;Label;Length;Liquid substance;Maps;Mass Spectrum Analysis;Mediating;Meiosis;Meiotic Prophase I;Microscopy;Mitosis;Mitotic;model organism;Mutagenesis;Mutation;Nature;offspring;Organism;Parents;Pattern;Phase;Phospho-Specific Antibodies;Phosphopeptides;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;PLK1 gene;polo-like kinase kinase 1;Process;Property;Prophase;protein complex;protein structure;recruit;Regulation;Reproduction;Research;response;Role;scaffold;Signal Transduction;Sister Chromatid;Site;Spontaneous abortion;Structure;Synaptonemal Complex;Tail;Testing;Therapeutic Intervention;Time;tool;transmission process;Work

PROJECT_TITLE: Investigating the role of Polo-like kinase in regulating synaptonemal complex dynamics


PHR: PROJECT NARRATIVE Lysine demethylase 5 (KDM5) proteins are essential for development, and their dysregulation is a key driver of intellectual disability and several forms of cancer. The C-terminus of KDM5 is a poorly characterized region of the protein but appears to mediate demethylase independent role(s) essential to viability and proper development in Drosophila. Using a variety of molecular approaches, we will define the critical regions of KDM5 required to regulate transcriptional programs(s) necessary for development and uncover important demethylase independent KDM5 roles which could contribute to human disorders.

PI_NAMEs: CASTIGLIONE, MELISSA  (contact)

PROJECT_TERMS: Address;Adult;Alleles;alpha helix;Amino Acid Sequence;Amino Acids;Animals;Binding;Biological Models;C-terminal;Characteristics;Chromatin;Chromatin Remodeling Factor;Conserved Sequence;Control Animal;Data;Defect;design;Development;Developmental Delay Disorders;Disease;Drosophila genus;Family;feature detection;fly;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genomics;Gland;Goals;histone demethylase;Histones;Homologous Gene;Human;in vivo;Intellectual functioning disability;Knowledge;Label;Lysine;Malignant Neoplasms;Mediating;Methylation;Molecular;molecular recognition;mutant;neuron development;Neurosecretory Systems;Nonsense Mutation;novel;paralogous gene;Pathway interactions;Phenotype;Play;Point Mutation;programs;Protein Family;protein protein interaction;Protein Region;Proteins;Proteomics;Publishing;recruit;Regulation;Regulator Genes;Role;Structure;Study models;targeted treatment;Terminator Codon;Testing;Tissues;tool;transcriptome sequencing;transcriptomics;Work

PROJECT_TITLE: Defining Activities of KDMS Essential to Development and Viability


ORG_NAME: NEW YORK UNIVERSITY

PHR: Project Narrative From a biologist’s perspective, cell migration is a hallmark of tissue morphogenesis in development, wound healing, and cancer metastasis. From a physicist’s perspective, collective cell migration can be viewed as a soft matter with collective mechanical phenomena. This research proposal will develop non-invasive methods and optogenetic tools to model in vivo force generation and transmission, further revealing the relationship between mechanical information and cell shape, and connect these aspects to observed biological phenomena (such as the Leader/Trailer polarity in Ciona) to provide a better understanding of collective cell migration.

PI_NAMEs: GUPTA, SELENA  (contact)

PROJECT_TERMS: Actomyosin;Affect;Back;Behavior;Bilateral;Biochemical;Biological Phenomena;Biological Process;biophysical properties;cell motility;Cell Shape;Cells;Cellular Morphology;Characteristics;Chordata;Communication;Computer Models;Coupling;Cytoskeletal Modeling;Cytoskeleton;Development;Dorsal;Embryo;embryo tissue;Endoderm;Epidermis;Equilibrium;Exhibits;Generations;Hydrostatic Pressure;improved;in vivo;in vivo imaging;in vivo Model;Individual;Intercellular Junctions;Invertebrates;kinematics;Maintenance;Measurement;mechanical signal;Mechanics;Methods;migration;Modeling;Morphogenesis;Morphology;Movement;Myosin ATPase;Neoplasm Metastasis;optogenetics;progenitor;Relaxation;Research Proposals;Reverse engineering;Role;Shapes;Side;spatiotemporal;Speed;stem cell migration;Structure;System;Tail;Testing;Tissues;tool;transmission process;Travel;Urochordata;Vertebrates;Work;wound healing

PROJECT_TITLE: Contribution of cell mechanics in promoting collective behavior for supracellular migration


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Research suggests that extensive repetitions of upper extremity (UE) activity can improve UE recovery post- stroke. A home exercise program (HEP) is commonly prescribed as part of rehabilitation therapy to facilitate greater repetitions of UE activity. Unfortunately, patient adherence to HEP is often low, limiting overall recovery. Behavioral interventions may be helpful in improving adherence, but there is no evidence of the effects of such interventions in stroke rehabilitation for Veterans. There is a need to understand the relationships among Veteran stroke survivors’ psychosocial factors, barriers and facilitators to HEP adherence, and objective HEP adherence. This is a necessary first step toward future development of a behavioral intervention that adequately addresses barriers and facilitators related to psychosocial factors to increase HEP adherence and promote recovery for Veterans with stroke.

PI_NAMEs: SCRONCE, GABRIELLE  (contact)

PROJECT_TERMS: Accelerometer;active duty;Address;Adherence;Admission activity;Affect;Behavior Therapy;Behavioral;career;Cellular Phone;Clinical Practice Guideline;Clinical Trials Design;community engagement;Data;Department of Defense;design;Development;Diabetes Mellitus;Doctor of Philosophy;effective intervention;Employment;exercise program;experience;flexibility;Foundations;Future;General Population;Goals;health literacy;Home;Human;Hypertension;Impairment;improved;Individual;Intervention;Interview;K-Series Research Career Programs;Kinesiology;Measures;Medical;medication compliance;Mentors;Mentorship;Methods;Monitor;Moods;motor recovery;Neuronal Plasticity;North Carolina;Observational Study;older adult;Outpatients;Patient Compliance;Patient Self-Report;Persons;Pharmaceutical Preparations;Physical activity;Physical Rehabilitation;physical therapist;Physical therapy;post stroke;Postdoctoral Fellow;Psychosocial Factor;Publications;Quality of life;Randomized, Controlled Trials;Recommendation;Recovery;Recovery of Function;Recreation;Regression Analysis;Rehabilitation therapy;Research;Research Methodology;Research Personnel;Research Training;Self Care;Self Efficacy;service member;skills;Sleep;South Carolina;Stroke;stroke rehabilitation;stroke survivor;Structure;Survivors;systematic review;Time;Training;Treatment/Psychosocial Effects;United States;United States Department of Veterans Affairs;Universities;Upper Extremity;Veterans;Visit;Work;Wrist

PROJECT_TITLE: Examining the association between psychosocial factors and adherence to a home exercise program for upper extremity recovery in Veteran stroke survivors

STUDY_SECTION_NAME: Career Development Program - Panel II[RRD9]


ORG_CITY: SAN DIEGO

ORG_NAME: VA SAN DIEGO HEALTHCARE SYSTEM

ORG_STATE: CA

PHR: Veterans have numerous risk factors (e.g., PTSD, TBI, cerebrovascular problems) for later-life cognitive and functional decline. Evidence supports the effectiveness of strategy-based cognitive rehabilitation therapies, including compensatory cognitive training (CCT), for such decline. However, questions remain about the length of time that CCT-driven improvements in cognitive and everyday function last, and whether additional ‘booster’ training sessions could provide additional benefit to aging Veterans who previously underwent treatment. The proposed study will examine the long-term durability of CCT in Veterans aged 55+ and will provide an opportunity to develop and pilot test a series of CCT booster sessions that can be personalized toward individual everyday functional goals. Ultimately, this study has the potential to improve cognitive function, functional independence, and quality of life for older Veterans. Results will advance cognitive rehabilitation science, inform future CCT treatment strategies for this high-priority Veteran population, and could improve healthcare for aging Veterans.

PI_NAMEs: MAYE, JACQUELINE E (contact)

PROJECT_TERMS: acceptability and feasibility;Activities of Daily Living;aged;Aging;Ambulatory Care;Area;Attention;Behavioral;career;cerebrovascular;Cognition;Cognitive;cognitive control;cognitive function;cognitive performance;cognitive rehabilitation;cognitive training;comparison control;Control Groups;Dementia;design;Development;Educational Intervention;Effectiveness;executive function;Feedback;follow-up;functional decline;functional independence;Funding;Future;Goals;Habits;Health;health care service utilization;Healthcare;Healthcare Systems;high risk;Impaired cognition;Impairment;improved;Individual;Inpatients;Institution;instrumental activity of daily living;Intervention;late life;Learning;Length;Long-Term Care;Manuals;Measures;Memory;Mentorship;Meta-Analysis;Methodology;mild cognitive impairment;military veteran;Mission;multi-component intervention;neuropsychiatry;Outcome;Participant;Performance;Pharmacological Treatment;pilot test;Post-Traumatic Stress Disorders;Postdoctoral Fellow;primary outcome;Protocols documentation;Quality of life;Randomized;Randomized, Controlled Trials;Recording of previous events;recruit;rehabilitation science;Rehabilitation therapy;Reporting;Research;Research Personnel;Risk;Risk Factors;secondary outcome;Series;Structure;systematic review;Techniques;therapy development;Time;Training;Traumatic Brain Injury;treatment as usual;treatment strategy;trial design;Veterans;Vietnam

PROJECT_TITLE: Assessing and Improving the Durability of Compensatory Cognitive Training for Older Veterans (AID-CCT)


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Cervical Cancer;Clinical Research;Genetics;Human Genome;Infectious Diseases;Precision Medicine;Prevention;Radiation Oncology;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Cervical cancer patients treated with standard of care (SOC) chemoradiation therapy (CRT) commonly experience disease recurrence, and current clinical testing and cancer genomic data cannot predict which patients will fail therapy before treatment or promptly detect disease recurrence after treatment. Our recent publications demonstrated that HPV genotypes and HPV alternative splicing affect LACC CRT response and patient outcome, and our preliminary data additionally identified a diversity of predictive HPV genomic structures (HPV-GS), including HPV-human gene fusions which affect their human oncogene partner expression. In this proposal, we will develop new HPV-GS based pre-treatment biomarkers, identify CRT-resistant HPV-GS in the context of CRT-induced clonal evolution, examine their mechanistic significance, and evaluate whether HPV-GS ctDNA tests can monitor LACC recurrence and metastasis.

PI_NAMEs: ZHANG, JIN  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Adenocarcinoma;Adjuvant;Adjuvant Chemotherapy;Affect;Aftercare;Alternative Splicing;alternative treatment;annotation  system;Biological Assay;Biological Markers;cancer diagnosis;cancer genomics;Cancer Patient;Cancer Personalized Profiling by Deep Sequencing;cancer recurrence;cancer survival;cervical cancer prevention;Cervix Neoplasms;Cessation of life;chemoradiation;chemotherapy;chronic infection;Cisplatin;Clinic;Clinical;clinical biomarkers;clinical sequencing;Clinical Trials;clinically actionable;Clonal Evolution;cohort;Data;Detection;Diagnosis;Disease;DNA;DNA sequencing;Early Diagnosis;Early Intervention;Episome;Evolution;Exons;experience;Failure;flexibility;fluorodeoxyglucose positron emission tomography;Gene Expression;Gene Expression Profile;Gene Frequency;Gene Fusion;Genes;genetic variant;Genome;genomic data;Genomics;Genotype;Goals;high risk;HPV-High Risk;Human;Human Chromosomes;Human papilloma virus infection;human papilloma virus oncogene;Human Papillomavirus;Hysterectomy;Image;Immunotherapy;improved;improved outcome;Keratin;Local Therapy;Machine Learning;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Manuals;Measures;Mesenchymal;Metabolic;Metastatic/Recurrent;Molecular;Monitor;neoantigens;Neoplasm Metastasis;Newly Diagnosed;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Outcome;outcome prediction;palliative;Patient-Focused Outcomes;Patients;Pattern;Plasma;Population;Prediction of Response to Therapy;prognostic value;programmed cell death ligand 1;Publications;radiation response;Radiation therapy;Radiosensitization;Randomized, Controlled Trials;Recurrence;Recurrent disease;Reporting;Research;research clinical testing;Resistance;response;Risk;Risk Assessment;risk stratification;RNA;Sampling;Series;Single Nucleotide Polymorphism;Staging;Staging System;standard of care;Stratification;Structure;Subgroup;Survival Rate;Targeted Radiotherapy;targeted sequencing;Technology;Testing;The Cancer Genome Atlas;therapy resistant;Time;tool;transcriptome sequencing;Treatment Failure;Treatment Protocols;treatment response;tumor;Tumor Bank;tumor DNA;vaccine acceptance;Validation;Variant;Visualization;Woman;women's diagnosis;X-Ray Computed Tomography

PROJECT_TITLE: HPV genomic structure in cervical cancer radiation response and recurrence detection

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Microbiome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE Native Hawaiians and Pacific Islanders (NHPIs) experience social inequities, such as low socioeconomic status, and suffer from a disproportionately higher prevalence and earlier onset of Type-2 diabetes mellitus (DM) than other racial/ethnic groups, however, the interactions between the social environment and biological mechanism(s) that underlie these disparities are unknown. We posit that the social environment conditions the epigenomic landscape and gut microbiome composition that regulate inflammation and metabolic pathways, which may precede the onset of DM. The prevalence of protective or adverse social factors may impinge on this “immunoepigenetic-gut microbiome axis” to give rise to the DM health disparities observed in NHPIs, a potential outcome of this study with generalizable implications for improving early identification of DM to enable preventative strategies for all.

PI_NAMEs: MAUNAKEA, ALIKA KEOLAOKALANI (contact)

PROGRAM_OFFICER_NAME: DAS, RINA

PROJECT_TERMS: Address;Adult;Affect;Age;Behavioral;Biological;Biological Availability;Black race;Blood;Cardiometabolic Disease;Characteristics;Chronic;cohort;Complex;Cross-Sectional Studies;Data;Data Set;deprivation;Development;Diabetes Mellitus;diabetes risk;diabetic;Diagnosis;Diet;Disparity;DNA Methylation;dysbiosis;Early identification;early onset;Educational Status;emerging adult;Enrollment;Environment;Epigenetic Process;epigenetic regulation;epigenomics;Ethnic Population;Etiology;experience;Exposure to;Filipino;follow-up;Gene Expression;Genes;Genetic Transcription;genome-wide;glycemic control;Glycosylated hemoglobin A;Goals;gut microbiome;Hawaii;Health;Health behavior;health disparity;health disparity populations;health inequalities;High Prevalence;high risk population;Hispanic;immune function;Immunologic Factors;improved;Incidence;Income;Indigenous;indigenous community;Individual;Inequity;Inflammation;Inflammation Mediators;Inflammatory;insight;Joints;Life Style;lifestyle intervention;low socioeconomic status;Measures;Mediating;Medical;medically underserved;Metabolic Pathway;microbiome composition;Modeling;monocyte;multidisciplinary;Native Americans;Native Hawaiian or Other Pacific Islander;Neighborhood Health Center;Neighborhoods;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Outcome;Outcome Study;Participant;Pathway interactions;Persons;Plasma;Population;Poverty;Prediabetes syndrome;Prevalence;Prevention strategy;prospective;Qualifying;Race;racial population;recruit;Research;Research Design;Risk;Risk Factors;segregation;social;social culture;social engagement;Social Environment;social factors;social influence;Social Network;Socioeconomic Status;System;systemic inflammatory response;Testing;trait;underserved community;Youth

PROJECT_TITLE: Socioecological Determinants of Immunoepigenetic Signatures of Diabetes Risk in Indigenous Communities


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FORDHAM UNIVERSITY

PHR: Project Narrative Both ethnic/racial minority and college student populations suffer from sleep disparities, including short sleep duration, poor sleep quality, and irregular sleep schedules. Yet, there is scant longitudinal research exploring the mechanisms and pathways through which race-related sleep disparities impact health and academic outcomes concurrently and over time among diverse college students. The current study employs an innovative combination of daily diaries and actigraphy, biannual surveys, annual dried blood spot biomarker samples, and anthropometric assessments to investigate the impact of sociodemographic and environmental stress on race-related sleep disparities from the first through senior year of college; informing researchers, public health experts, and educators about the social-biomedical mechanisms through which stress impacts ethnic/racial minority health and academic disparities.

PI_NAMEs: YIP, TIFFANY  (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: actigraphy;Address;Adult;Affect;African American student;Anxiety;Asian;Behavior Therapy;biobehavior;Biological Markers;Black race;Blood;Buffers;Chronic;cognitive function;college;critical developmental period;Data;Development;diaries;Disparity;Dryness;Environment;environmental stressor;Ethnic Origin;Ethnic Population;evidence base;executive function;flexibility;Generations;Goals;Health;health determinants;health disparity;health equity;Health Policy;Heart Diseases;high school;High School Student;Hypertension;Inflammation;Inflammatory;innovation;Intervention;Investigation;Latinx;Length;life span;Link;Longitudinal Studies;Maintenance;Malignant Neoplasms;Measures;Mediating;Mental Depression;Meta-Analysis;minority health;minority student;Modeling;novel;Obesity;Outcome;outcome disparities;Pathway interactions;peer;Physiological;poor sleep;Population;pressure;Prevalence;protective effect;Public Health;Race;racial disparity;racial identity;racial minority;racism;Reduce health disparities;Reporting;Research;Research Personnel;Risk;Risk Behaviors;Sampling;Schedule;Science;Sleep;Sleep disturbances;sleep pattern;sleep quality;social;social determinants;Social Environment;Social Sciences;sociocultural determinant;sociodemographics;Socioeconomic Status;socioeconomics;Spottings;Stress;stressor;Students;success;Surveys;telomere;Time;United States;university student;urban setting;Vulnerable Populations;young adult

PROJECT_TITLE: Social-Environmental Predictors of Sleep Disparities During the Transition toCollege

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE These studies will use an animal model that lacks submucosal glands to investigate the relative role of submucosal glands and surface epithelia to airway host defense in hopes of accelerating development of new treatments for lung diseases.

PI_NAMEs: STOLTZ, DAVID A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acceleration;Airway Disease;airway surface liquid;Animal Model;anti-microbial peptide;antimicrobial;Asthma;Bacteria;Chronic Obstructive Pulmonary Disease;Cystic Fibrosis;Data;Development;Distal;ectodysplasin;Epithelium;Exposure to;Family suidae;Foundations;Functional disorder;Future;Genes;Gland;gland development;Host Defense;Human;Impairment;improved;Infection;Inflammation;Knowledge;Lung;Lung Diseases;lung health;Mammals;Mediating;Modeling;MUC5AC gene;MUC5B gene;Mucociliary Clearance;Mucous body substance;Newborn Infant;novel therapeutic intervention;particle;PET/CT scan;Play;Process;Production;Proteins;Pulmonary Challenge;Regulation;respiratory;respiratory challenge;Role;Site;Submucosa;Surface;Techniques;Testing;Time;Virus

PROJECT_TITLE: Testing the Contributions of Airway Submucosal Glands and Surface Epithelia to Lung Health

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Unintentional Childhood Injury

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE Teen drivers who have committed a traffic violation are at increased risk for crashes, injuries, and deaths. Through partnership with the local Juvenile Traffic Court, this randomized controlled trial will assess the effectiveness of an innovative in-vehicle driving feedback technology, with and without parent training, on reducing risky driving events, unsafe driving behaviors, and recidivism among high-risk teen drivers, which correlates with NICHD’s mission to prioritize research on teen driver safety.

PI_NAMEs: YANG, JINGZHEN GINGER (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acceleration;Adolescent;Age;Appearance;Automobile Driving;Behavior;Cause of Death;Cessation of life;Communication;comparison control;Control Groups;County;court;Devices;distracted driving;driving behavior;driving safety;effective intervention;Effectiveness;effectiveness evaluation;Enrollment;Event;Evidence based program;Fatality rate;Feedback;Frequencies;Goals;group intervention;Hearing;high risk;high risk population;improved;improved outcome;Injury;innovation;Intervention;intervention effect;Legal Guardians;Licensing;Measures;Mission;National Institute of Child Health and Human Development;novel;Ohio;Outcome;Outcome Study;parenting intervention;Parents;Phase;Policies;prevent;programs;Randomized;Randomized, Controlled Trials;recidivism;recruit;Research;Research Priority;Risk;risky driving;Safety;Seat Belts;smartphone application;Specialist;Speed;Summary Reports;Supervision;System;Technology;technology training;teen drivers;teen driving;Teenagers;Testing;therapy design;Time;Training;United States;universal prevention;unsafe driving;Vehicle crash;virtual

PROJECT_TITLE: Intervention to Improve Driving Practices Among High-Risk Teen Drivers

STUDY_SECTION: CLHP

STUDY_SECTION_NAME: Community-Level Health Promotion Study Section[CLHP]


NIH_SPENDING_CATS: Data Science

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE We wish to continue our development of new reactions and modern data science tools for applications in the synthesis of bioactive molecules. Progress in these fields will have a significant impact in how molecules are prepared for biomedical applications. A particular emphasis involves building new data-driven workflows, which empower a wide-range of enterprises related to medicine.

PI_NAMEs: SIGMAN, MATTHEW S (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Acceleration;Algorithms;Catalysis;catalyst;chemical synthesis;Communities;computational chemistry;cost;Coupled;Data;Data Collection;data mining;Data Science;Data Set;design;Development;empowerment;Foundations;insight;interest;Knowledge;Mathematics;Medicine;Methods;Modernization;novel strategies;optimism;Outcome;Pathway interactions;Performance;Process;process optimization;programs;Reaction;Reagent;Sorting;Statistical Methods;Statistical Models;Substrate Interaction;tool;training data;uptake;Work

PROJECT_TITLE: Data Science Guided Organic Reaction Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


ORG_CITY: DALLAS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The ability of cells to control their shape and architecture in response to changing cell-external and -internal conditions is the basis of almost every aspect in normal physiology. Deficiencies in this control are the cause of innumerable pathologies and diseases. In this research program, the PI and his laboratory will continue to develop innovative research methods integrating molecular cell biology, live cell microscopy, computer vision, and statistical and mathematical modeling to probe the complex interplay of spatially and temporally distributed chemical signals and mechanical forces that underlie the morphogenic processes.

PI_NAMEs: DANUSER, GAUDENZ  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Actins;Adopted;Algorithms;Architecture;Cell Physiology;Cell Shape;Cells;Cellular biology;Chemicals;Complex;Computer Vision Systems;Coupling;Cytoskeleton;Development;Disease;Environment;Etiology;Experimental Designs;Feedback;imaging modality;innovation;insight;Laboratories;live cell imaging;live cell microscopy;mathematical model;mechanical force;Mechanics;Mediating;Molecular;Morphogenesis;Pathology;Pathway interactions;Phenotype;Physiology;Polymers;Process;programs;Regulation;Research;Research Methodology;response;rho GTP-Binding Proteins;Series;Shapes;Signal Transduction;Statistical Models;System;Time;Tissues;tool;Work

PROJECT_TITLE: Functional causality in regulating cell morphogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: WINSTON-SALEM

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Despite experiencing multiple stressors, immigrant populations, including those of Mexican immigrants, generally have better health outcomes than subsequent US-born generations. Recent research indicates that individual experiences and stress exposures translate into physical changes to biological systems; other factors may buffer the negative effects of the exposure. This project is designed to identify the stressors involved in immigration, and potentially the biological mechanisms they target, with the potential goal of improving behavioral, psychological, and physical health of immigrants and subsequent generations.

PI_NAMEs: HOWARD, TIMOTHY D;SANDBERG, JOANNE CHRISTINE (contact)

PROGRAM_OFFICER_NAME: MARTIN, IMAN

PROJECT_TERMS: Acute;Address;Affect;Age;age group;age-related disease;Behavior;Behavioral;behavioral health;Biological;biological age;Biological Markers;biological systems;Blood specimen;Buffers;Cell Aging;Characteristics;Chromosomes;Chronology;Country;Data;Data Analyses;Data Collection;design;Development;disease phenotype;DNA Methylation;early childhood;Economics;Education;Educational Status;Emotional;Employment;Epigenetic Process;epigenomics;Etiology;Event;experience;Face;Gene Expression Profile;General Population;Generations;Goals;graduate school;Health;health disparity;Heart Diseases;high school;Immigrant;Immigration;improved;Individual;Interview;Latinx;Length;Life;life span;Life Style;Lived experience;Measurable;Measurement;Measures;Mediating;Mental Health;Mexican;Migrant;Migrant Workers;migration;North Carolina;Occupations;Outcome;Participant;peripheral blood;Personal Satisfaction;physical conditioning;Physiological;Population;Process;psychologic;public health research;Religious Belief;Research;Resources;response;Shapes;Social support;Stress;Stressful Event;stressor;structural determinants;Structure;telomere;Telomere Shortening;Translating;Trauma;United States;Variant;Violence;Work

PROJECT_TITLE: Migrant and Multi-generational Immigrant Experiences: The Effects of Stressors on Epigenetic, Behavioral, and Health-related Outcomes


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Nearly all synapses in the brain exhibit some form of short-term plasticity, yet the computational functions of this plasticity are poorly understood. This proposal applies innovative methods to develop fundamental knowledge about how synaptic plasticity implements the canonical computation of temporal pattern separation. An improved understanding of how the brain processes information over time could help guide the development of improved therapies for memory-related disorders.

PI_NAMEs: JEANNE, JAMES MCCLURE (contact)

PROGRAM_OFFICER_NAME: DAVID, KAREN KATE

PROJECT_TITLE: Synaptic mechanisms of temporal pattern separation


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: GAINESVILLE

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: FL

PHR: Vagus nerve stimulation may hold the key to treating many different conditions, including obesity. Obesity is a growing epidemic in our country. Obese Veterans are at risk for hypertension, diabetes, and depression. Stimulating the vagus nerves, which innervate the stomach, with small, therapeutic levels of electricity provides a potential avenue for weight loss but is not well understood. Successful reduction of excess body weight has been reported, but stimulus parameters are quite variable, and it is unclear how parameters map to outcomes. To facilitate stimulus optimization, both invasive recordings and non-invasive imaging studies should be conducted in animal models first. Ideally, stimulus would be applied bilaterally and near the stomach, but currently available electrode interfaces do not allow this. This research aims to a) develop a new interface that will allow bilateral stimulation near the stomach and b) map the relationship between stimulus parameters and 1) nerve recruitment and 2) brain activity. Studies will be conducted in rats.

PI_NAMEs: SCHIEFER, MATTHEW ANTHONY (contact)

PROJECT_TERMS: Acute;Address;Adoption;Affect;Animal Experiments;Animal Model;Area;Axon;bariatric surgery;Bilateral;Body Weight;Body Weight decreased;Brain;Brain region;Cardiac Output;Cervical;Charge;Chronic;Clinic;Clinical;clinical practice;Communication;comorbidity;cost estimate;Country;Dangerousness;Data;density;design;Development;Diabetes Mellitus;Diet;diet and exercise;Dorsal;driving force;Elasticity;Electric Stimulation;Electricity;Electrodes;Emerging Technologies;Epidemic;Esophageal Stenosis;Esophagus;experimental study;Exposure to;Failure;Feasibility Studies;Fiber;Food;food consumption;Functional Magnetic Resonance Imaging;Future;Gastric Balloon;Glucose;Goals;Health;Heart Diseases;Heating;Hypertension;imaging study;Implant;Individual;Ingestion;Intestines;Left;Legal patent;Letters;Link;Location;Longterm Follow-up;magnetic field;Magnetic Resonance Imaging;Maps;Mechanics;Mechanoreceptors;Medical Device;Mental Depression;Methodology;Microscopic;minimal risk;Morphologic artifacts;Motivation;Nerve;Neuronal Plasticity;non-invasive imaging;novel;Obesity;obesity management;Operative Surgical Procedures;Organ;Outcome;Overweight;Pattern;Perception;Pharmaceutical Preparations;Population;pre-clinical;pressure;Publications;Rattus;recruit;Regimen;Reporting;Research;Research Personnel;Rewards;Risk;Rodent;Rodent Model;Safety;Satiation;Sensory;Series;side effect;Stenosis;Stimulus;Stomach;Stretching;success;Surface;System;Technology;Testing;Therapeutic;Time;Tissues;tool;Translating;Translations;vagus nerve stimulation;Vagus nerve structure;Veterans;Veterans Health Administration;Visceral Afferents;Weight

PROJECT_TITLE: Design and testing of a novel circumesophageal cuff for chronic bilateral subdiaphragmatic vagal nerve stimulation (sVNS)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Lupus;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Systemic lupus erythematosus (SLE, or lupus) is a chronic multisystem autoimmune disease characterized by the production of autoantibodies, disproportionately affecting women and African Americans, with whom it is associated with significant mortality and morbidity, and without safe and effective treatments. This project seeks to identify and characterize the epigenetic mechanisms by which positive and negative social experiences affect gene function and thereby influence SLE in African American women. The proposed research is relevant to public health because it could lead to improvements in our understanding of the etiology of SLE and its disparities, facilitating the development of targeted precision medicine approaches to reduce morbidity, mortality, and close the health disparities gap.

PI_NAMEs: RAMOS, PAULA SOFIA (contact)

PROJECT_TERMS: accelerated epigenetic aging;Address;Advisory Committees;Affect;African American population;African American Women;African ancestry;African Women;aged;Anxiety;Autoantibodies;Autoimmune Diseases;Behavioral;Bioinformatics;Blood Cells;Blood specimen;Cell Physiology;Characteristics;Chronic;Clinical Medicine;cohort;Communities;community partnership;Compensation;Data;Death Rate;Development;Disease;disease disparity;Disease Outcome;Disparity;disparity gap;Disproportionately impacts women;DNA Methylation;effective intervention;effective therapy;Energy Metabolism Pathway;Enrollment;Environmental Exposure;Environmental Risk Factor;epigenetic clock;Epigenetic Process;epigenome;epigenomics;Etiology;experience;Exposure to;Family;Gene Expression;gene function;Genes;Genetic;genetic variant;Genomics;Genotype;Goals;Health;Health Disparities Research;health disparity;health disparity populations;Household;Human;Immune;improved;Income;Individual;Inflammatory;Infrastructure;Island;Joints;Knowledge;Lead;Leukocytes;Life Cycle Stages;Linear Regressions;Lupus;machine learning method;Measures;Mediation;Medical;Mendelian randomization;Mental Depression;Methylation;minority health;minority health disparity;Modeling;Modification;Molecular;Morbidity - disease rate;mortality;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Outcome;outcome disparities;Participant;Patient Self-Report;perceived stress;physiologic stressor;Physiological;Population;precision medicine;predictive modeling;Predisposition;Prevalence;preventive intervention;Production;prototype;Psychosocial Factor;Public Health;racial discrimination;racism;recruit;Registries;Research;Research Project Grants;resilience;resilience factor;response;Risk Factors;Sea;Severities;Severity of illness;Site;social;Social Environment;social epidemiology;social factors;social health determinants;social stressor;Social support;sociodemographics;Socioeconomic Status;statistics;stressor;System;Systemic Lupus Erythematosus;Testing;transcriptome sequencing;transcriptomics;Variant;Woman

PROJECT_TITLE: Social Factors, Epigenomics, and Lupus in African American women (SELA)


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Regenerative Medicine;Wound Healing and Care

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Dysfunctional angiogenesis and the resultant lack of vascularization is a potentially lethal issue that affects tens of millions of patients in the United States alone. Current treatments do not contend with the complexities of the angiogenic process and fail to promote stable blood vessel growth. Here we propose an investigation into the role of macrophages in angiogenesis, and the design of a biomaterials-based strategy to control macrophage behavior and promote complete vascularization and healing.

PI_NAMEs: O'BRIEN, ERIN MICHELLE (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adoptive Transfer;Affect;angiogenesis;Behavior;Biocompatible Materials;Blood Vessels;Bone Marrow;Categories;CCL17 gene;Cell Therapy;Cells;Cessation of life;Chronic Disease;chronic wound;Coculture Techniques;CXCR4 gene;design;Diabetes Mellitus;Disease;dosage;drug action;Endothelial Cells;Exhibits;Flow Cytometry;genetic signature;Goals;Growth;Growth Factor;healing;Human;Immune;Immune response;Immunohistochemistry;In Vitro;in vivo;Inflammatory;Interleukin-4;Investigation;limb amputation;Macrophage;Mediating;monocyte;mouse model;Mus;next generation sequencing;novel;particle;Pathology;Patients;Peripheral arterial disease;Phagocytosis;Pharmaceutical Preparations;Phase;Phenotype;Platelet-Derived Growth Factor;Population;Process;recruit;response;Role;Simvastatin;skin wound;Stimulus;Structure;Time;tissue regeneration;Tissues;transcriptome sequencing;Transplantation;United States;Vascularization;Wound models

PROJECT_TITLE: Designing Biomaterials to Promote the M1-to-M2 Macrophage Transition and Enhance Angiogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F10C-C(20)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: American Indian or Alaska Native;Arctic;Bioengineering;Clinical Research;Data Science;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Alaska Native people predominate in rural Alaska where the lack of roads creates a dependency on air medical evacuation (medevacs) for access to emergency care which in turn creates the highest medevac rate, the highest airplane crash rate, and the poorest access to emergency care of any region in the US. Work proposed in this grant aims to generate a novel medevac outcomes database from existing electronic health records, combine those data with community-engaged qualitative methodology to ultimately create context-specific machine learning models able to classify the appropriateness of medevac utilization. This continuum of research has the potential to directly address the disparities in access to and outcomes of emergency care experienced by both Alaska Native people in rural Alaska and by rural Americans more generally, by improving the safety, timeliness and appropriateness of medevacs.

PI_NAMEs: RICE, BRIAN TRAVIS (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acceleration;access disparities;Accidents;Acute;Address;Affect;Air;Alaska;Alaska Native;Alaska Native population;Alaskan;American;Artificial Intelligence;Award;Behavioral;Benefits and Risks;biomedical informatics;care delivery;career;Classification;Clinical;clinical care;clinical decision-making;Collaborations;Communities;community engagement;computer program;cost;Data;data management;Data Science;Databases;Death Rate;Decision Making;Dependence;Development;Disparity;Disparity population;Electronic Health Record;Emergency Care;Emergency Medicine;Emergency Situation;empowerment;Epidemiology;Equity;evidence base;Excess Mortality;expectation;Expenditure;experience;Future;global health;Goals;Grant;Guidelines;Health;Health Disparities Research;health disparity;Improve Access;improved;informant;innovation;Interview;learning strategy;Machine Learning;machine learning classification;machine learning method;machine learning model;Medical;Medical Informatics;Mentors;Mentorship;Methodology;model building;Modeling;novel;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;Physicians;Population;professor;Publications;Qualitative Methods;Qualitative Research;Quality of Care;Research;Research Assistant;Research Personnel;Research Proposals;Resource-limited setting;Resources;Rice;Risk;Rural;rural Alaska;rural Americans;rural area;Safety;Scientist;skills;stakeholder perspectives;statistics;Structure;Students;Surveys;System;Testing;Time;tool;Training;Training Activity;Underserved Population;Universities;urban area;Work;Yukon-Kuskokwim Delta

PROJECT_TITLE: Machine Learning Models of Appropriate Medevac Utilization in Rural Alaska


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SAN JUAN

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: The Hispanic Clinical and Translational Research Education and Career Development (HCTRECD) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) will continue to develop and implement innovations that will enhance our program’s capacity and infrastructure to support even more Hispanics in research careers that can address how to reduce health disparities. To continue pursuing this goal, we will improving methodological knowledge and skills and addressing barriers to obtaining K awards. The overall goal of the HCTRECD program is to increase the number of Hispanics from different disciplines performing clinical and translational research while also increasing the knowledge on the causes and interventions that can help reduce health disparities.

PI_NAMEs: MARTINEZ GONZALEZ, KAREN G. (contact);SEGARRA-VAZQUEZ, BARBARA

PROJECT_TERMS: academic program;Address;Admission activity;Area;Audiology;Award;career;career development;Clinic;Clinical;Clinical Research;Clinical Sciences;clinical trial participant;Collaborations;Consultations;Country;Dental;Dentistry;Development Plans;Diabetes Mellitus;Discipline;Discipline of Nursing;Education;education research;Educational Curriculum;Educational workshop;Enrollment;Ensure;expectation;experience;Funding;Goals;Grant;Health;Health Disparities Research;health disparity;Health Personnel;Health Professional;Hispanic;Hispanic Populations;HIV/AIDS;improved;Infant;Infrastructure;innovation;Institution;Intervention;Justice;K-Series Research Career Programs;Knowledge;Knowledge acquisition;Leadership;Learning;Malignant Neoplasms;Master of Science;Maternal Health;Medical;Medicine;meetings;Mental Health;Mentors;Mentorship;Methodology;Minority Groups;minority healthcare;next generation;novel;Occupational Therapy;Oral health;Outcome;patient oriented research;Peer Review;Pharmacy facility;Pilot Projects;Population;population health;Postdoctoral Fellow;precision medicine;Productivity;Program Development;Program Evaluation;programs;Psychology;Publications;Puerto Rico;Qualifying;recruit;Reduce health disparities;Research;Research Personnel;Research Support;Research Training;Science;skill acquisition;skills;Structure;success;timeline;Training;Training Activity;Training Programs;Translational Research;Underrepresented Populations;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Hispanic Clinical and Translational Research Education and Career Development Program


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Physical inactivity is associated with worse asthma outcomes, and African American women are disproportionately impacted by both physical inactivity and asthma. Research aimed at addressing the unique asthma-related and culture-specific barriers to physical activity in this vulnerable population of women is needed. The proposed study will test the efficacy and implementation potential of ACTION (A lifestyle physiCal acTivity Intervention for minOrity womeN with asthma) to increase physical activity and asthma health outcomes to reduce the burden of asthma in African American women.

PI_NAMEs: NYENHUIS, SHARMILEE MARIA (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Adult;African American population;African American Women;Age;Asthma;asthma exacerbation;Behavioral;Behavioral Mechanisms;care systems;Clinical Treatment;Clinical Trials;comorbidity;Complex;Control Groups;Data;Disproportionately impacts women;Education;efficacy evaluation;efficacy study;efficacy testing;efficacy trial;Environment;Evaluation;evidence base;exercise intervention;experience;fitbit;Fright;Goals;Health;health care service utilization;health disparity;Healthcare Systems;improved;Income;Individual;Informal Social Control;Intervention;intervention effect;Life;Life Style;lifestyle intervention;Maintenance;Measures;Mediation;Mediator;Methods;Minority Groups;Minority Women;Monitor;mortality;Motivation;Neighborhoods;Outcome;Outcome Assessment;Participant;Patients;Performance;Physical activity;physical inactivity;poor health outcome;Population;Population Intervention;programs;Quality of life;Questionnaires;Randomized;recruit;remote group;Research;Resources;response;Self Efficacy;Severities;Site;social health determinants;Social support;Solid;Testing;Text;Text Messaging;texting support;theories;therapy design;Training and Education;treatment response;Urban Health;urban setting;Vulnerable Populations;Walking;White Women;Woman;Work

PROJECT_TITLE: ACTION, A lifestyle physiCal acTivity Intervention for MinOrity womeN with asthma: From Efficacy to Implementation

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

PHR: PROJECT NARRATIVE Our project seeks to reduce the unequal burden of hypertension after pregnancy of Black women, which is a major driver of severe maternal disease and death and long-term heart disease. We propose a novel trial that compares an enhanced multi-level intervention (home blood pressure monitoring and postpartum heart health doula support) to usual care that will be an equitable, scalable and sustainable strategy to improve the health of all women with hypertension in pregnancy. Our intervention is aligned with the NIMHD objectives to generate new knowledge to improve health outcomes of racial minority populations affected by health inequities using a multi-level intervention that addresses patient, health professionals, system and community factors.

PI_NAMEs: CATOV, JANET M (contact);DAVIS, ESA M

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;Adherence;Adverse event;Affect;Biometry;Black race;black women;Blood Pressure;blood pressure control;Blood Pressure Monitors;Cardiac health;Cardiovascular Diseases;Caring;Cessation of life;Chronic;Clinical;clinical application;clinical care;Clinical Trials;Communities;community engaged approach;community engagement;community partners;community partnership;community-level factor;Coupled;COVID-19 pandemic;Data;Discipline of obstetrics;Disease;Disparity;Education;enhanced care;Enrollment;Ensure;Epidemiology;Equity;Event;evidence base;experience;Family Practice;feasibility trial;Guidelines;Health;health care disparity;health care service;health difference;health equity;health inequalities;Health Professional;Heart Diseases;Heart failure;high risk;Home Blood Pressure Monitoring;Home visitation;Hospitals;Hypertension;improved;Incidence;Inequity;innovation;Intervention;Knowledge;Life Style;Maternal and Child Health;maternal morbidity;Maternal Mortality;Measurement;Mission;Monitor;mortality;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Outcome;Patients;Population;post pregnancy;postpartum complications;Postpartum Period;Pre-Eclampsia;Pregnancy;pregnancy disorder;pregnancy hypertension;pressure;prevent;programs;Psychiatry;Race;racial difference;racial disparity;racial minority population;randomized trial;Recovery;recruit;Research;Risk;service delivery;Services;severe maternal morbidity;Single-Blind Study;Site;social media;socioeconomics;Stroke;System;Testing;Time;treatment as usual;trend;trial comparing;two-arm trial;virtual intervention;Weight;White Women;wireless;Woman;Women's Health

PROJECT_TITLE: Eliminating racial disparities in severe maternal morbidity by addressing hypertension in the year after delivery


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Evidence suggests that access to green schoolyards may facilitate play and physical activity to help prevent excess weight gain in children, improve academic outcomes, and help the community at large. The Little Rock Green Schoolyards Initiative, a program aiming to promote outdoor learning and play in low-income schools, is a unique opportunity to evaluate the role of such interventions on physical activity through environmental and social pathways. The program also provides an opportunity to evaluate the potential impact of green school yard interventions on other academic and community outcomes and assess potential barriers to successful implementation.

PI_NAMEs: THOMSEN, MICHAEL R. (contact)

PROJECT_TERMS: Active Learning;Address;Affect;African American;Air;Area;Behavior;Behavioral;Body mass index;cardiometabolic risk;cardiometabolism;Characteristics;Child;Cities;Communities;Community Health;Complement;cost effective intervention;Data;design;Development;Dimensions;Effectiveness;elementary school;Environment;excessive weight gain;experience;fourth grade;Future;Goals;Green space;Growth;Health Benefit;health disparity;High Prevalence;high risk;Hour;implementation barriers;improved;innovation;Intervention;Learning;Link;Literature;Low income;Modeling;Morbid Obesity;Natural experiment;Nature;Neighborhoods;novel;Obesity;obesity development;obesity in children;Outcome;Pathway interactions;Pattern;Performance;Personal Satisfaction;Physical activity;Play;Prevalence;prevent;programs;Quasi-experiment;Recreation;Reduce health disparities;Risk;Role;school district;Schools;sleep behavior;social;Social Behavior;Strenuous Exercise;Time;Training;United States;walkability;Walking;Work

PROJECT_TITLE: The Little Rock Green Schoolyard Initiative: Changing Community Norms and Improving Opportunities for Physical Activity


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Hearing Loss;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: PROJECT NARRATIVE Human inferior colliculus plays a major role in auditory processing, but technical limitations have made it difficult to study in vivo. In this project we will implement ultra-high field magnetic resonance imaging techniques in living humans to characterize the anatomy and connectivity of this subcortical auditory structure and its role in speech category learning. This will uncover structure-dependent MRI contrast within living human midbrain and its contributions to speech communication with clinical applications related to hearing disorders and midbrain auditory implants.

PI_NAMEs: SITEK, KEVIN RICHARD (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Acoustics;Adult;Anatomy;Animal Model;Auditory;Auditory area;auditory categorization;auditory pathway;auditory processing;Auditory system;auditory thalamus;Brain;Brain region;Categories;Cell Nucleus;Clinical;clinical application;clinically relevant;Cochlear Implants;Communication;Complex;contrast imaging;Diffusion Magnetic Resonance Imaging;Dissociation;Dorsal;Ear;Electrophysiology (science);Environment;Frequencies;Functional Magnetic Resonance Imaging;Future;hearing impairment;Hearing problem;Human;Human Characteristics;Image;Imaging Techniques;Implant;in vivo;in vivo imaging;Individual;Inferior Colliculus;Investigation;Learning;Location;magnetic field;Magnetic Resonance Imaging;Maps;Mediating;Mentors;Methodology;Methods;Midbrain structure;neural;neural implant;next generation;novel;Participant;Pathway interactions;Pattern;Phase;Play;Process;programs;Property;Protocols documentation;Research;Research Project Grants;Resolution;response;Role;Route;Scalp structure;Self-Help Devices;Sensorineural Hearing Loss;Sensory Disorders;Signal Transduction;sound;Specificity;Speech;Speech Sound;Stimulus;Structure;System;Techniques;Testing;theories;Time;Tinnitus;Tissues;tractography;Training;white matter

PROJECT_TITLE: Investigating human non-lemniscal inferior colliculus contributions to auditory learning with 7T MRI

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Rural Health;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Program Director/Principal Investigator (Last, First, Middle): Shah, Vallabh O and Herman Carla Falls and fall-related injuries are major health risks for our disparity population of American Indian elders. Our pilot study showed 52% of Zuni elders reporting a fall during the past year, which is significantly higher than the US national average of one out of three adults 65+. In partnership with Zuni Pueblo leadership and community stake holders, we seek to study the feasibility of implementing Community Health Representative (CHR) delivered fall risk screening and evidence-based Otago Exercise Program to address lack of access to home- delivered physical therapy and health disparity, as well as empower elders to address fall risk, avert injury, and preserve aging in place within their community.

PI_NAMEs: HERMAN, CARLA JEAN;SHAH, VALLABH O (contact)

PROGRAM_OFFICER_NAME: FERNANDEZ, ANGELA R

PROJECT_TERMS: access disparities;Address;Adult;aged;aging in place;American Indian Population;American Indians;arm;Assisted Living Facilities;Automobile Driving;barrier to care;Chronic Disease;Collaborations;Communities;community collaboration;community engagement;Community Health;Community Networks;comorbidity;compare effectiveness;Consultations;Control Groups;Disparity;Disparity population;Education;Effectiveness;Elderly;empowerment;Equilibrium;evidence base;Evidence based intervention;exercise program;experience;fall injury;Fall prevention;fall risk;falls;Family;family structure;Feasibility Studies;Focus Groups;follow-up;Fostering;Frequencies;General Population;Geography;Geriatric Assessment;Goals;Health;health care disparity;health care quality;health disparity;Health Sciences;Health Status;Health Surveys;Home;human old age (65+);improved;Injury;innovation;Intervention;intervention program;Knowledge;Language;Leadership;Long-Term Care for Elderly;Measures;Modeling;native elder;New Mexico;novel;Outcome;Participant;physical conditioning;physical therapist;Physical therapy;Pilot Projects;Population;preference;preservation;Prevention program;prevention service;Prevention strategy;preventive intervention;Principal Investigator;programs;Pueblo Race;Randomized;Recording of previous events;Rehabilitation therapy;rehabilitative care;Reporting;Research;Reservations;Risk;Risk Management;Risk Reduction;Role;rural area;screening;Self Efficacy;Self Management;Services;SF-12;Skilled Nursing Facilities;skills;social engagement;Social Network;standard of care;telehealth;Training;treatment as usual;tribal community;Tribal Elders;tribal leader;tribal member;Tribes;United States Indian Health Service;Universities;Visit;Work;Zuni

PROJECT_TITLE: Standing Strong in Tribal Communities: Assessing Elder Falls Disparity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-H(55)]


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH Spinal cord injury (SCI) affects 1.3 million Americans. The proposed experiments in this application are relevant to public health because they will elucidate mechanisms for how neuronal activation promotes axon growth, thus identifying potential therapeutic targets. Additionally, they will test whether neuronal activation – alone or in combination with other manipulations – promotes functional axon regeneration after SCI.

PI_NAMEs: TOM, VERONICA JEAN (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acetylation;Adult;Affect;American;Automobile Driving;Axon;axon growth;axon regeneration;Back;Behavioral;Central Nervous System;Cervical spinal cord injury;Chondroitin ABC Lyase;Chondroitinases;Cicatrix;Clozapine;constitutive expression;Crush Injury;Cytoskeleton;Data;designer receptors exclusively activated by designer drugs;Digestion;Disparate;dorsal column;Environment;experimental study;Fostering;FRAP1 gene;Genetic;Goals;gray matter;Growth;Guanosine Triphosphate Phosphohydrolases;improved;In Vitro;in vitro Model;in vivo;Injury;Kinesin;knock-down;Lead;Length;Mediating;Methods;Microtubules;Modeling;Motor;Multiple Trauma;Natural regeneration;Neurons;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oxides;Peripheral Nerves;permissiveness;Play;Population;Proteins;Public Health;Ras homolog enriched in brain;Recovery;Recovery of Function;Recurrence;repaired;response;Role;Sensorimotor functions;Sensory;Spinal;Spinal Cord;Spinal cord injury;Spinal Ganglia;spinal nerve posterior root;Structure;Synapses;Testing;Therapeutic;therapeutic target;Transplantation

PROJECT_TITLE: Multipronged approach to promote functional axonal regeneration in the spinal cord after injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-E(03)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PUBLIC HEALTH RELEVANCE More than six million Americans suffer from neurodegenerative diseases, for which there are no good treatments. We are studying how a protein called NMNAT2 provides neuroprotection in the mammalian central nervous system with a long-term goal of developing therapies to treat neurodegenerative diseases, including Alzheimer's disease and Alzheimer’s disease related dementia.

PI_NAMEs: LU, HUI-CHEN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Age;age related decline;Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease therapy;American;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid precursor protein processing;Attenuated;Axon;axonal degeneration;Axonal Transport;axonopathy;Bayesian Analysis;Biology;Brain;brain metabolism;Bypass;Central Nervous System;Chronic;cofactor;cognitive function;combat;Compensation;Data;Defect;design;Development;disease model;Down-Regulation;drug discovery;Energy Supply;Enzymes;Face;fast axonal transport;Financial cost;Genes;Genetic study;Gliosis;Glucose;glucose metabolism;Glutamate-ammonia-ligase adenylyltransferase;Glutamates;Glycolysis;Goals;Golgi Apparatus;Health;Hippocampus;Homeostasis;Human;Huntington Disease;Hyperactivity;hyperphosphorylated tau;Image;Impairment;in vivo;Inflammation;insight;Knockout Mice;Knowledge;Life;Link;Maintenance;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Molecular;Molecular Chaperones;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurons;neuroprotection;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide riboside supplementation;novel;novel therapeutic intervention;Oxidative Phosphorylation;Parkinson Disease;Pathology;Pentosephosphates;Phenotype;Play;Prevalence;prevent;Process;programs;Proteins;Proteolytic Processing;public health relevance;Resolution;response;Risk Factors;Role;sensor;social;Spinal Cord;Supplementation;Synaptic Transmission;Synaptic Vesicles;synaptogenesis;tau Proteins;Testing;theories;Therapeutic;therapeutic target;therapy development;Time;Up-Regulation;Visualization

PROJECT_TITLE: Molecular and genetic studies of NMNAT2 in neuroprotection

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Defects in homeostatic signaling at synapses are associated with a variety of neurological and neuropsychiatric diseases including epilepsy, autism, schizophrenia, Fragile X Syndrome, ALS, and Alzheimer's Disease. However, the mechanisms that ensure stable synaptic strength remain poorly understood. This proposal seeks to reveal fundamental mechanisms that initiate and maintain homeostatic signaling at synapses, insights that are necessary for understanding disease etiology.

PI_NAMEs: DICKMAN, DION KAI (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Acute;Aging;Alzheimer's Disease;Amino Acids;autism spectrum disorder;Biological Models;C-terminal;calmodulin-dependent protein kinase II;Central Nervous System;Chemosensitization;Chronic;Communication;Complex;Data;Defect;density;Development;Disease;DLG4 gene;Drosophila genus;Electrophysiology (science);Endowment;Ensure;Epilepsy;Etiology;excitotoxicity;experience;experimental study;flexibility;Fragile X Syndrome;Functional disorder;Functional Imaging;gene interaction;Genes;Genetic;Genetic Screening;Glutamate Receptor;Glutamates;Goals;Growth;Health;Homologous Gene;Human;Image;imaging approach;Impaired cognition;innovation;insight;Invertebrates;Learning;Mediating;Modeling;Molecular;Molecular Genetics;Motor Neurons;Nature;Nerve Degeneration;Nervous System;Nervous System Disorder;Neuromuscular Junction;neuropsychiatric disorder;neuroregulation;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;novel;Organism;Pathway interactions;Peripheral Nervous System;pharmacologic;postsynaptic;presynaptic;Process;receptor function;recruit;Rodent;Role;scaffold;Schizophrenia;Seizures;Signal Transduction;sleep behavior;Structure;Synapses;synaptic function;Synaptic plasticity;System;Tail;Testing;transmission process;ubiquitin ligase;ubiquitin-protein ligase;ultra high resolution;Work

PROJECT_TITLE: Molecular Mechanisms Governing the Homeostatic Control of Synaptic Strength

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Epilepsy;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: Project Narrative We recently discovered that mice with hyperactive stress circuits exhibit an increased incidence of SUDEP. Given that both stress and SUDEP link to disruption of central circuits responsible for the regulation of cardiorespiratory function, this application will interrogate a potential, novel pathophysiological mechanisms contributing to SUDEP involving hyperactive stress circuits and exaggerated cardiac vagal output. This application has the potential to uncover a novel mechanism contributing to SUDEP risk, which may also be relevant to other forms of sudden death.

PI_NAMEs: MAGUIRE, JAMIE LYNN (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Apical;Apnea;Autonomic Dysfunction;Behavioral;Biological Markers;Brain Stem;Cardiac;Cardiovascular system;Chronic;Chronic stress;comorbidity;Corticotropin-Releasing Hormone;Data;Electrophysiology (science);Environmental Risk Factor;Epilepsy;Exhibits;Functional disorder;Genetic;genetic approach;Genetically Engineered Mouse;Heart Arrest;Heart Rate;Hyperactivity;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;Impairment;Incidence;Injections;innovation;Laboratories;Link;Lung;Mediating;Methods;Modeling;Motor;Motor output;Mus;Neurons;Neurosecretory Systems;novel;Nucleus solitarius;Output;paraventricular nucleus;Pathway interactions;Patients;pharmacologic;Physiology;Radio;Reflex action;Regulation;respiratory;response;Risk;Role;Seizures;Sensory;Stress;Sudden Death;sudden unexpected death in epilepsy;Tachycardia;Telemetry;Testing;Therapeutic;Whole Body Plethysmography

PROJECT_TITLE: CRH dysregulation of brainstem autonomic circuits increases SUDEP risk


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE This project seeks to develop methods that can be used to study prenylated proteins. This class of proteins in involved in controlling many key event within cells. These new methods should facilitate the discovery of new protein targets that could be used to develop new therapeutic agents for the treatment of a wide range of diseases ranging from Alzheimer's disease to cancer.

PI_NAMEs: DISTEFANO, MARK D (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Alzheimer's Disease;Biological Assay;cancer therapy;Cell Culture Techniques;Cells;Chemicals;Clinical Trials;Coupled;Cysteine;Development;Disease;disease model;Event;experimental study;improved;inhibitor;isoprenoid;isoprenylation;Label;Length;Ligation;Light;Link;Malaria;Malignant Neoplasms;Mammalian Cell;Masks;Metabolic;Methods;Microscopy;Modeling;Modification;Molecular Chaperones;Monitor;mouse model;new therapeutic target;novel therapeutics;Nuclear Structure;Parkinson Disease;Penetration;Peptides;Play;Post-Translational Protein Processing;precision medicine;prenylation;Prevalence;Process;Progeria;Protein Isoprenylation;Proteins;Proteomics;RAS driven cancer;Reaction;Research;Role;Sampling;Signal Transduction;Site;sortase;Therapeutic Agents;Therapeutic Intervention;Time;tumorigenesis;Virus Diseases

PROJECT_TITLE: Chemical Approaches for Exploring Protein Prenylation in Living Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Adolescent alcohol use has a detrimental impact on the brain and is a risk factor for impulsivity and development of addictive disorders in adulthood. Despite this, there is a fundamental lack of mechanistic understanding of how adolescent alcohol use affects the brain because most research effort has focused on adult models. The proposed project seeks to determine how voluntary adolescent alcohol drinking causes impulsivity and alters neural networks in adulthood in order to elucidate neuronal consequences of adolescent alcohol exposure.

PI_NAMEs: MOGHADDAM, BITA  (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: addiction;Adolescence;Adolescent;adolescent alcohol exposure;Adolescent Development;Adult;Adult women;adverse outcome;Affect;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohols;Animal Model;Animals;Anxiety Disorders;Association Learning;Behavior;behavior observation;Behavioral;behavioral impairment;Behavioral inhibition;Behavioral Model;Behavioral Paradigm;Brain;Brain region;Clinical;clinically relevant;Communication;Computer Analysis;Control Animal;Corpus striatum structure;cue reactivity;Cues;Data;design;designer receptors exclusively activated by designer drugs;Development;Dorsal;drinking;Electrophysiology (science);Ethanol;Event;experience;experimental study;Exposure to;Feeling suicidal;Female;flexibility;Future;Genetic;genetic approach;genetic manipulation;Impairment;Impulsivity;Individual;intervention effect;Knowledge;Laboratories;Lateral;Lead;Learning;Link;Literature;male;mature animal;Medial;Mediating;Mental Processes;Modeling;Mood Disorders;neural;neural network;Neurons;novel;Outcome;Pathway interactions;Protocols documentation;Rattus;receptor;Recording of previous events;Research;response;Rewards;Risk Factors;Rodent;Role;Signal Transduction;Substance Use Disorder;Sucrose;Suicide attempt;Task Performances;Testing;underage drinking;Water;Work

PROJECT_TITLE: Long term consequences of adolescent alcohol use on behavioral inhibition

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative  A new class of anticancer drugs called PARP inhibitor has been approved by US FDA to treat recurrent ovarian cancer. However, resistance has also been observed, and patients receiving PARP inhibitors eventually develop cancer progression. In this project, we plan to investigate a new mechanism of PARP inhibitor resistance in ovarian cancer, and test the therapeutic potential of a new compound, called ALDH1A1 inhibitor, in treating PARP inhibitor-resistant ovarian cancer.

PI_NAMEs: WANG, QIEN  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: aldehyde dehydrogenases;Aldehydes;Antineoplastic Agents;Binding;brca gene;BRCA mutations;BRCA1 gene;BRCA1 Mutation;BRCA2 gene;BRCA2 Mutation;cancer cell;Cell Death;Cell Survival;Cells;Chemoresistance;Clinical;Development;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-Directed DNA Polymerase;Double Strand Break Repair;efficacy testing;Enzymes;Epithelial ovarian cancer;expectation;Family;FDA approved;female reproductive tract;Genes;Genetic Transcription;Goals;homologous recombination;homologous recombination deficiency;improved;In Vitro;in vivo;inhibitor;Maintenance Therapy;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Metabolism;mouse model;mutant;Mutate;mutation carrier;Nonhomologous DNA End Joining;novel;overexpression;Pathway interactions;patient derived xenograft model;Patients;Platinum;Poly(ADP-ribose) Polymerase Inhibitor;prevent;Production;Promoter Regions;Protein Isoforms;recombinational repair;Recurrence;Relapse;repaired;Reporting;Resistance;Resistance development;restoration;Retina;Retinoic Acid Receptor;Retinoic Acid Response Element;Role;Survival Rate;synergism;targeted treatment;Testing;Therapeutic;therapeutic evaluation;Tretinoin;tumor progression

PROJECT_TITLE: Role of ALDH in PARP inhibitor resistance in HR-deficient ovarian cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE This grant aims to increase understanding of disease biology in patients with an atypical presentation of Alzheimer’s disease. We will use longitudinal imaging techniques to determine whether brain function, iron deposition and genetics are related to how the proteins tau and beta-amyloid spread through the brain. The findings will improve our understanding of the mechanisms that drive the disease and could ultimately allow the appropriate targeting of future therapies in Alzheimer’s disease.

PI_NAMEs: WHITWELL, JENNIFER LOUISE (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Address;Affect;Age;age difference;Alzheimer's Disease;Alzheimer's disease patient;American;Amyloid beta-Protein;Aphasia;Apolipoproteins;Area;Automobile Driving;Behavior;beta amyloid pathology;Biological;Biological Models;Biology;Blood;Blood specimen;Brain;cerebral atrophy;Clinical;Cognitive;cohort;Data;Deposition;Development;Disease;Functional Magnetic Resonance Imaging;Future;Genetic;genetic analysis;genetic risk assessment;genetic risk factor;genetic variant;genome sequencing;Genotype;Goals;Grant;Heterogeneity;Imaging Techniques;improved;in vivo;Individual;Intervention;Iron;Knowledge;Language;Link;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Memory Loss;Modeling;molecular imaging;Multimodal Imaging;Nerve Degeneration;neuroimaging;Neurologic;Neuropsychological Tests;novel;Other Genetics;Pathology;Patients;Pattern;Persons;Pittsburgh Compound-B;Positron-Emission Tomography;Predisposition;programs;Proteins;Public Health;recruit;Research;Rest;Risk Estimate;Route;serial imaging;skills;spatial relationship;structural imaging;Syndrome;tau Proteins;Techniques;uptake;Variant;Visuospatial;whole genome;Work

PROJECT_TITLE: Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal study


NIH_SPENDING_CATS: Behavioral and Social Science;Contraception/Reproduction;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Infertility;Social Determinants of Health

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: PROJECT NARRATIVE This project addresses the family planning goals of Healthy People 2030. It does so by generating foundational demographic knowledge that is necessary to our understanding of intended and unintended childbearing, adolescent childbearing, and short interbirth intervals. Its results will contribute to our understanding of how fertility has been affected by the pandemic, which is a prerequisite for addressing this impact, e.g. by identifying and appropriately targeting policies and social security programs that will allow people to recover from this shock to their childbearing.

PI_NAMEs: ROOT, LESLIE  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Accounting;Address;Adolescent;Affect;Age;age group;age related;aged;Attention;Baby Booms;Birth;Birth History;Birth Order;Birth Rate;Black race;Censuses;Characteristics;Child;child bearing;Completed Family Sizes;Complex;Contraceptive methods;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Data;Data Security;Data Set;Data Sources;Ethnic Origin;Family Planning;Female;Fertility;Fertility Rates;Fertility Study;Funding;Geography;Goals;Grain;Health;Health Insurance;Heterogeneity;Hispanic;Household;improved;Income;Individual;Inequality;Knowledge;Link;Location;Low Income Population;Medical;Methods;Modeling;Morbidity - disease rate;mortality;National Institute of Child Health and Human Development;Nature;novel;pandemic disease;pandemic impact;parity;Pattern;Persons;Policies;Population;Positioning Attribute;pre-pandemic;prevent;programs;Race;Records;Reproduction;Research Design;Research Personnel;Schedule;Services;Shock;Social Security;sociodemographics;Socioeconomic Status;Source;stem;Subgroup;Taxes;theories;Time;Translating;trend;Variant;Woman;Work

PROJECT_TITLE: Beyond Boom and Bust: Heterogeneous Fertility Effects of the COVID-19 Pandemic

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE The proposed research develops a novel strategy to identify and target the natively expressed forms of the nicotinic acetylcholine receptor as they contribute to addiction, a persistent public health issue in the United States. Using a yeast-display immune screen, this project will generate a new biological tool to accurately track and modify the activity of these receptor proteins in the brain, thus providing a promising avenue to develop improved tools for smoking cessation and other addiction therapies. This proposal is thus highly relevant to the NIH's primary function of studying and treating human health and disease.

PI_NAMEs: PETERS, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: HILLERY, PAUL

PROJECT_TERMS: Acetylcholine;Acute;addiction;Affinity Chromatography;Arousal;Attention;Behavior;Behavioral;Binding;Binding Sites;Biological;Biological Assay;Biological Availability;Brain;cell type;Cells;cholinergic;cholinergic neuron;Chronic;combat;Complex;counterscreen;Dependence;Development;Diagnostic;Discrimination;Disease;Drug Addiction;Drug Exposure;drug of abuse;effectiveness testing;Electrophysiology (science);Exhibits;Family;Fluorescence;Future;Generations;Genes;Goals;Grant;Habenula;Health;Heterogeneity;Human;human disease;Immune;Immunotherapy;improved;In Vitro;in vivo;Individual;innovation;interpeduncular nucleus;Ion Channel Gating;Knock-out;Lead;Libraries;Ligand Binding;Ligands;Link;Magnetism;Mammalian Cell;Medial;Methodology;Methods;Midbrain structure;Molecular;Molecular Conformation;molecular diagnostics;Molecular Target;nanobodies;Nervous System;Neurobiology;Neurons;Neurotransmitters;Nicotine;Nicotinic Agonists;Nicotinic Receptors;novel;novel strategies;Output;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phenotype;Physiological;Property;protein distribution;protein expression;Proteins;Psychological reinforcement;Public Health;Reagent;receptor;receptor-activity-modifying protein;Regulation;Research;Rewards;Rodent;screening;Signal Transduction;smoking cessation;stoichiometry;System;Tegmentum Mesencephali;Therapeutic;therapeutic target;tool;Transgenic Model;United States;United States National Institutes of Health;Ventral Tegmental Area;Yeasts

PROJECT_TITLE: Developing nanobody immune libraries against native neuronal nicotinic receptor complexes

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative: The trace element iron is a necessary nutrient needed for normal functions of myoglobin, hemoglobin, and many iron-containing redox enzymes. Ferroportin is the only iron exporter in humans and is the focus of the current proposal. I will investigate the structure and function of ferroportin and its regulation by a small peptide hormone hepcidin.

PI_NAMEs: PAN, YAPING  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Affinity;antiporter;Binding;Binding Sites;Biological Assay;Cells;Complex;Cryoelectron Microscopy;Endocytosis Induction;Enzymes;extracellular;Fab Immunoglobulins;Family;Foundations;Future;Genus Tarsius;Goals;Hemochromatosis;Hemoglobin;hepcidin;Hereditary Disease;Homeostasis;Human;improved;indexing;inhibitor;Ion Transport;Ions;Iron;iron deficiency;Iron deficiency anemia;Iron Metabolism Disorders;Iron Overload;Lipids;Liver;Mammals;Maps;Measures;Mediating;member;Metal Ion Binding;metal transporting protein 1;Metals;Molecular Conformation;Monoclonal Antibodies;Mutation;Myoglobin;nanodisk;Nutrient;Oxidation-Reduction;peptide hormone;reconstitution;Regulation;Resolution;Role;Side;Site;small molecule;small molecule inhibitor;Solid;solute;Solvents;Structure;Symptoms;therapeutic target;three dimensional structure;Trace Elements;Visualization

PROJECT_TITLE: Structure and mechanism of mammalian ferroportin

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]