NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: KING OF PRUSSIA

ORG_NAME: MERLIN THERAPEUTICS INC

PHR: PROJECT NARRATIVE Patients suffering from the progressive, currently incurable genetic disorder Neurofibromatosis type 2 (NF2), which causes tumor growth throughout the nervous system, face a shortened lifespan and a lifetime of devastating neurological symptoms that remain unaddressed by current treatment technologies. Merlin Therapeutics is developing a unique gene therapy allowing NF2 deficient cells to produce a healthy version of the lacking NF2 protein in all cell types affected by the disease, thereby addressing the underlying disease cause. The proposed project will confirm existing preliminary data and establish dose-response, safety, and biodistribution data for our lead gene therapy candidate to bridge the gap to the next steps to a future clinical trial and position this vector as a potential preventive and/or treatment for NF2.

PI_NAMEs: HENWOOD, NICOLE  (contact);NAEIMI KARAROUDI, MEISAM

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acoustic Neuroma;Address;adeno-associated viral vector;Affect;Animal Diseases;animal safety;Animals;Arachnoid mater;Area;autosomal dominant mutation;Biodistribution;Brain;burden of illness;Cancer Patient;Cell Line;Cell Separation;cell type;Cells;Central Nervous System;Cerebrospinal Fluid;Characteristics;chemotherapy;Clinic;Clinical Research;Clinical Trials;Code;Data;deafness;design;Development;Disease;disease phenotype;Dose;effective therapy;efficacy study;Ependymal Cell;Ependymoma;Equilibrium;Etiology;Evaluation;Face;Family;FDA approved;Functional disorder;Future;gene replacement therapy;gene therapy;gene-targeted therapy;General Hospitals;Genes;Genetic Diseases;Goals;Growth;Human;immune cell infiltrate;Immune response;Implant;improved;In Vitro;in vivo;in vivo Model;Inflammation;Injections;innovation;Lead;lead candidate;life span;Massachusetts;meningioma;Modeling;mouse model;Mus;Muscle;Mutation;neoplastic cell;Nerve;Nerve Fibers;Nervous System;Nervous System Disorder;Neurilemmoma;Neurofibromatosis 2;Neurofibromin 2;Neurologic Symptoms;Neuropathy;new growth;novel;Operative Surgical Procedures;Pain;Paralysed;Pathologist;Pathology;patient population;Patients;Pattern;Pediatric Hospitals;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Phase;Positioning Attribute;preclinical study;prevent;Preventive;programs;promoter;Promoter Regions;Proteins;psychologic;Quality of life;Radiation;Recurrent tumor;Reporter;response;Safety;safety study;Sampling;Schwann Cells;sciatic nerve;side effect;Societies;socioeconomics;technological innovation;Technology;Therapeutic;Tissues;Transgenes;translational therapeutics;tumor;tumor growth;Tumor Suppressor Proteins;Tumor Volume;vector;Viral Genome;Viral Vector;Vision;Western Blotting;Wild Type Mouse;Xenograft procedure

PROJECT_TITLE: Development of a Novel AAV9 Gene Replacement Therapy for Neurofibromatosis Type 2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-R (12)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Substance Misuse;Tobacco

ORG_CITY: AMHERST

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE People with substance use disorder have difficulty quitting and are susceptible to relapse even after long periods of abstinence. Recent findings have suggested that a single dose of psychedelic drugs can lead to both decreases in smoking and reduce the chance of relapse. This project will use a rat model of nicotine addiction to determine the conditions under which the psychedelic drug psilocybin can promote abstinence and prevent relapse.

PI_NAMEs: MEYER, PAUL J (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;Affective;Agonist;Animal Model;Animals;anti-depressive agents;Anxiety;Behavioral;behavioral response;cigarette smoking;craving;Cues;Desire for food;Dose;drug of abuse;Effectiveness;Electronic Nicotine Delivery Systems;Emotional;Environment;experience;experimental group;experimental study;Future;Goals;Hallucinogens;Health;HTR2A gene;Human;Incubated;Individual;Injections;insight;Laboratory Study;Learning;Measures;Mental disorders;Modeling;Motivation;negative affect;negative emotional state;neural;neurobehavioral;Neurobiology;Nicotine;Nicotine Dependence;nicotine replacement;nicotine self-administration;nicotine use;Nicotinic Receptors;novel;novel therapeutics;Persons;Pharmaceutical Preparations;pharmacologic;Post-Traumatic Stress Disorders;Predisposition;Procedures;Process;Property;Psilocybin;Psychological reinforcement;Psychotherapy;Rattus;receptor;Relapse;relapse prevention;response;Rodent Model;Role;Saline;Serotonin;Serotonin Agents;Serotonin Receptor 5-HT2A;Smoking;Smoking treatment;Source;Substance Use Disorder;Testing;Therapeutic;Therapeutic Effect;translational approach

PROJECT_TITLE: Set and setting: the effects of psilocybin on nicotine self-administration in rats

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Palliative Care;Physical Activity;Prevention;Radiation Oncology;Rehabilitation;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project will examine the feasibility, acceptability, and usability of delivering a yoga intervention to patients with lung cancer undergoing radiotherapy and their family caregiver via a mobile application. The project also seeks to determine preliminary efficacy of this app-based program regarding patient physical function and patient and caregiver quality of life.

PI_NAMEs: MILBURY, KATHRIN  (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Address;Cancer Center Support Grant;cancer diagnosis;Cancer Etiology;Cancer Patient;Caregiver Burden;caregiver quality of life;Caregivers;caregiving;Caring;Cessation of life;Chest;clinical care;common symptom;Communities;Community Care Networks;Community Clinical Oncology Program;community setting;comparison group;Core Facility;Correlation Studies;cost effective;Data;design;Detection;Development;Disease;Disparity;Dyspnea;effectiveness testing;effectiveness trial;efficacy evaluation;efficacy trial;Eligibility Determination;Emotional;evidence base;experience;Family;Family Caregiver;Family member;Fatigue;Feedback;Female;field study;flexibility;formative assessment;Funding;future implementation;Goals;High Prevalence;implementation research;improved;innovation;instructor;Intervention;intervention delivery;Knowledge;Low income;male;Malignant neoplasm of lung;Measurement;Mental Depression;Methods;Minority;mobile application;Non-Small-Cell Lung Carcinoma;novel;Outcome;Outcome Study;parent grant;parent project;Parents;Participant;Patient Care;patient oriented;Patient Triage;Patient-Focused Outcomes;Patients;Persons;Physical Function;physical symptom;pilot trial;Play;Population;primary outcome;Process;programs;prototype;psychologic;psychological distress;psychological symptom;pulmonary function;Qualitative Methods;Quality of Care;Quality of life;Radiation therapy;Randomized, Controlled Trials;Recontacts;Reporting;Research;Resource Sharing;Risk Factors;Role;Schedule;Single-Blind Study;Sleep disturbances;social health determinants;Source;Suggestion;Supportive care;Taxes;Testing;Time;trial design;United States;uptake;usability;user centered design;Vulnerable Populations;Work;Yoga

PROJECT_TITLE: Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Genetics;Hematology;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Sepsis

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Klebsiella pneumoniae are major causes of antibiotic resistant infections worldwide. We hypothesize that K. pneumoniae bloodstream infections are caused by mixed populations of genetically and phenotypically distinct strains, rather than a single strain as long believed. In this project, we will characterize genetic and phenotypic diversity of K. pneumoniae strains recovered from blood cultures, determine if genetic diversity correlates with antibiotic treatment failure, and implicate specific genes in antibiotic resistance, antibiotic tolerance, and virulence.

PI_NAMEs: NGUYEN, M. HONG THI (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Antibiotic Resistance;antibiotic resistant infections;Antibiotic susceptibility;Antibiotic Therapy;antibiotic tolerance;Antibiotics;Antimicrobial Resistance;Bacteria;Biological Assay;Blood;Blood Circulation;carbapenem resistance;Centers for Disease Control and Prevention (U.S.);Clinical;Clinical Microbiology;clinically relevant;clinically significant;Data;Diagnosis;Exhibits;Extended Spectrum Beta lactamase producing Enterobacterales;Extended-spectrum β-lactamase;Gastrointestinal tract structure;Gene Deletion;Gene Mutation;Genes;Genetic;genetic variant;Genetic Variation;Genome;Genotype;Gram-Negative Bacteria;gut colonization;Hospitalization;Human;human pathogen;In Vitro;Individual;individual patient;Infection;insight;Klebsiella;Klebsiella pneumoniae;Medical;Morphology;mortality;Mus;mutant;Mutation;opportunistic pathogen;Organ;Pathogenesis;Patients;Pattern;Phenotype;Phylogeny;Plasmids;Polysaccharides;Population;Predisposition;pressure;priority pathogen;Public Health;Random Allocation;Recurrence;research study;Resistance;resistance gene;resistant Klebsiella pneumoniae;response;Sepsis;Sequence Analysis;Serum;Single Nucleotide Polymorphism;Site;Sterility;stressor;Symbiosis;Testing;Time;Treatment Failure;Virulence;virulence gene;whole genome;World Health Organization

PROJECT_TITLE: Within-host diversity of Gram negative bacteria from bloodstream infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AIRT-J (01)]


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Cancer cells can acquire resistance to drug treatment in ways that are not driven by genetic changes, yet can be inherited as the cancer cells divide. Here we propose a technology to discover the cellular mechanisms governing inheritance with the expectation that what we learn will be useful to design therapeutic regimens that anticipate cellular responses to therapy.

PI_NAMEs: BLAINEY, PAUL CLARK (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Antineoplastic Protocols;Bar Codes;base editor;Benchmarking;Biological Models;cancer cell;Cancer cell line;cancer therapy;cancer type;Carboplatin;Cell Death;Cell Line;Cells;chemotherapy;Cisplatin;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Complex;CRISPR interference;Data;Data Set;daughter cell;design;Disease Progression;Dose;Dropout;Drug resistance;Ensure;Environment;expectation;Frequencies;Future;Genes;Genetic;Genomics;Goals;Guide RNA;Heritability;in situ sequencing;in vivo Model;Inherited;Learning;Libraries;live cell imaging;Malignant neoplasm of ovary;Malignant Neoplasms;Measurement;Measures;Metabolic;Methods;Microscopy;Mitochondria;Molecular;Monitor;Mutation;non-genetic;novel therapeutics;Optics;optimal treatments;Performance;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;reconstruction;Regimen;Reporter;Reproducibility;Resistance;Resolution;Sampling;System;Technology;theories;Therapeutic;Therapeutic Effect;Time;Toxic effect;trait;Treatment Failure;Treatment Protocols;treatment response;Trees;Work

PROJECT_TITLE: Profiling and perturbing the inheritance of drug-induced metabolic states in cancer with Inheritance-Seq

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-D (O1)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The 3q29 deletion is associated with a high risk of neurodevelopmental and neuropsychiatric disorders. We propose to use a novel approach to investigate the function of genes in the 3q29 deletion in the developing brain. Our central goal is to understand how genes in chromosomal regions that are highly associated with neuropsychiatric disorders, including the 3q29 deletion, affect brain development, which will advance our understanding of the biological mechanisms underlying these disorders.

PI_NAMEs: HOFFMAN, ELLEN J (contact);MULLE, JENNIFER GLADYS

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: 16p11.2;22q11.2;3q29;7q11.23;Affect;aged;Arousal;autism spectrum disorder;Automobile Driving;Behavior;Behavioral;behavioral phenotyping;Biological;Body Size;Brain;Brain Mapping;burden of illness;Candidate Disease Gene;Cerebellum;Clustered Regularly Interspaced Short Palindromic Repeats;Clutch Size;Code;cognitive ability;Combinatorics;Complex;Copy Number Polymorphism;CRISPR/Cas technology;Custom;Data;Development;Disease;Exhibits;flexibility;Functional disorder;Gene Combinations;Gene Deletion;gene function;gene interaction;Genes;Genomics;Goals;Growth;high reward;high risk;high throughput analysis;high throughput screening;Human;human study;in vivo;Individual;innovation;insight;interest;Investigation;life span;Link;loss of function;Methods;microdeletion;Molecular;Morbidity - disease rate;mosaic;mouse model;Mus;mutant;neural circuit;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;novel;novel strategies;Outcome;Outcomes Research;Pathogenicity;Pathway interactions;Phenotype;Proteins;Psychoses;Ramp;Rapid screening;Research;response;risk variant;Role;Schizophrenia;schizophrenia risk;Sensory;sensory stimulus;Severities;single-cell RNA sequencing;Sleep;Structure;Study Subject;Symptoms;Syndrome;System;Technology;Testing;Time;Transfection;Variant;Visual;Work;Zebrafish

PROJECT_TITLE: Functional Analysis of 3q29 Microdeletion Syndrome Driver Genes

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Prevention

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Simple and sensitive detection of viral load in patient blood samples at home is highly desired for detection of early and rebound HIV infections, especially in individuals undergoing PrEP. The goal of this project is to develop a novel electrochemical diagnostic platform we call HIV-eCaDI (HIV Capillary Driven Immunoassay) that can be used by PrEP patients to detect HIV p24 antigen at ~10 pg/ml concentrations at home in a rapid, sensitive, and user friendly format. HIV-eCaDI will be a valuable diagnostic platform for detecting acute HIV infections and help patients closely monitor their HIV status in the privacy of their own homes.

PI_NAMEs: DANDY, DAVID S;GEISS, BRIAN  (contact);HENRY, CHARLES S

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Academic Medical Centers;Acute;acute infection;Algorithms;Anti-Retroviral Agents;Antibodies;antibody detection;antigen detection;Antigen Presentation;Antigens;antiretroviral therapy;Automation;Binding;Biological Assay;Biological Markers;Biosensor;Blinded;Blood capillaries;Blood specimen;Blood Volume;Buffers;Carbon;Cellular Phone;Characteristics;Chemistry;Clinic;Clinical;clinically relevant;Colorado;Communicable Diseases;Communication;cost;Custom;Data;data management;design;Detection;detection limit;detection platform;Development;Device Designs;Devices;Diagnostic;diagnostic assay;diagnostic platform;Diagnostic tests;DNA;Early Diagnosis;Electrochemistry;Electrodes;Enzyme-Linked Immunosorbent Assay;experience;Generations;Goals;Health;Heart;HIV;HIV Core Protein p24;HIV Genome;HIV Infections;HIV Seropositivity;HIV-1;Home;home test;Human immunodeficiency virus test;Hybrids;Immunoassay;improved;Individual;Infection;Infrastructure;Integrated Health Care Systems;Interruption;Laboratories;Letters;Marketing;Measurement;medical schools;Methods;Microfluidic Microchips;Microfluidics;Modality;Monitor;Morbidity - disease rate;mortality;New York City;novel;Nucleic Acid Amplification Tests;Paper;particle;pathogen;pathogenic virus;Patient Monitoring;Patients;Performance;Phase;Physicians;point of care;point-of-care diagnostics;Point-of-Care Systems;portability;pre-exposure prophylaxis;Preparation;Privacy;prophylactic;Proteins;prototype;Provider;Public Health;Quality of life;rapid detection;rapid testing;Reagent;Resource-limited setting;response;Rest;RNA;Running;sample collection;Sampling;self testing;Sensitivity and Specificity;sensor;Serum;Specificity;Specimen;standard of care;System;Systems Integration;Technology;Telemedicine;Testing;Therapeutic;Time;transmission process;United States National Institutes of Health;Universities;user-friendly;Validation;Viral;Viral Antigens;viral detection;Viral Load result;viral RNA

PROJECT_TITLE: Development of a robust HIV-1 diagnostic system (HIV-eCaDI) for at-home testing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 JBS-A (S1)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE  The overall goal of this project is to understand the principles that underlie epithelial immunity against viruses. By identifying how intestinal epithelial cells detect viruses and respond to infection, the proposed studies will provide fundamental knowledge about the role of epithelial cells in infectious diseases. This work will uncover novel defense mechanisms that may inform the basic biological processes underlying viral infections and autoimmune diseases in humans.

PI_NAMEs: BATACHARI, LAKSHMI ELAINE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Address;Affinity;Animal Model;antiviral immunity;Autoimmune Diseases;Base Sequence;Biological Assay;Biological Process;Body Surface;Caenorhabditis elegans;cell type;Cells;Communicable Diseases;Defense Mechanisms;Double-Stranded RNA;enteric pathogen;Epithelial Cells;Epithelium;Epitopes;experimental study;Exposure to;Genetic;Genetic Transcription;Goals;Homologous Gene;Human;Immune;Immune response;Immune signaling;Immunity;in vivo;Infection;Innate Immune Response;innovation;insight;Interferon Type I;Interferons;intestinal epithelium;Intestines;Invaded;IRF3 gene;Knowledge;Label;Location;Mammals;Mediating;Methods;Mitochondria;Modeling;Molecular;Mutagenesis;N-terminal;Nematoda;novel;Outcome;overexpression;pathogen;Pathway interactions;Pattern recognition receptor;programs;protein protein interaction;receptor;Receptor Signaling;receptor-mediated signaling;Regulation;Resistance;response;RNA Helicase;RNA Interference;RNA replication;Role;screening;sensor;Shapes;Signal Pathway;Signal Transduction;Specificity;Testing;Tissues;tool;transcriptome sequencing;translational impact;Viral;viral detection;viral RNA;Virus;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Dissecting host-virus interactions in epithelial cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07C-S (20)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PORTLAND

ORG_NAME: PORTLAND VA MEDICAL CENTER

ORG_STATE: OR

PHR: The TBI literature provides preliminary evidence supporting associations between TBI exposures and poor health and functional outcomes, and extant longitudinal cohort studies of service members and Veterans with military combat and training exposures offer researchers access to extant data addressing factors that modify risks for developing and/or recovering from a range of brain disorders, including TBI, PTSD, pain, depression, and suicidality. Pooling individual participant level data from longitudinal TBI research studies will result in a large enough dataset to consider relevant moderators, mediators, and confounders in analyses and allow for more impactful and clinically meaningful findings. We have developed a model data harmonization system to combine data from multiple heterogenous studies and facilitate the analysis of a single pooled dataset. The research team will develop a 2-year plan to define a standardized approach and create a crosswalk for the modalities and domains of LIMBIC and TRACTS longitudinal cohort to create a unified assessment profile that can be analyzed.

PI_NAMEs: O'NEIL, MAYA ELIN (contact)

PROJECT_TERMS: Address;Algorithms;associated symptom;Biological Markers;Brain Diseases;brain health;Brain Injuries;Categories;Center for Translational Science Activities;Clinical;cohort;Collaborations;combat;comorbidity;Data;Data Analyses;data harmonization;data modeling;Data Pooling;data resource;data reuse;Data Set;Disparate;Elements;Ensure;experience;FAIR principles;follow-up;functional outcomes;Funding;Health;health knowledge;Image;Individual;Knowledge;large scale data;Leadership;Liquid substance;Literature;Longitudinal cohort;Longitudinal cohort study;longitudinal dataset;Longitudinal Studies;longitudinal, prospective study;Machine Learning;Measurement;Measures;Mediator;Mental Depression;Mental disorders;Metadata;method development;Methods;Military Personnel;Modality;multimodal data;multimodality;Names;Natural Language Processing;Pain;Participant;Pattern;physical symptom;Physiological;pilot test;Post-Traumatic Stress Disorders;Prognostic Factor;programs;prospective;Recovery;Reproducibility;Research;Research Personnel;research study;Resources;Risk;Risk Factors;service member;Site;Source;Standardization;stress disorder;success;suicidal;Symptom Burden;System;Techniques;Training;Veterans;Walking;Work

PROJECT_TITLE: Harmonizing Veteran Longitudinal Cohorts to Identify Prognostic Factors in Post-Traumatic Brain Health

STUDY_SECTION: RRDB

STUDY_SECTION_NAME: Brain Injury[RRDB]


NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The tumor microenvironment overpowers the human immune system by repeatedly engaging cytotoxic T cells with inhibitory immune checkpoint molecules, rendering the T cells dysfunctional. Immune checkpoint blockade (ICB) therapy works to overcome these suppressive interactions in hopes of inducing durable tumor regression in cancer patients who have limited therapeutic alternatives, however therapeutic response rates are quite low and vary on an individual basis. Our preliminary data links overexpression of Dual Specificity Phosphatase 2 (DUSP2) within human CD8+ T cells to dampened responses to ICB and this proposal will aim to elucidate the network controlling response and allow for the identification of therapeutic targets that may improve ICB responses in the future.

PI_NAMEs: DELLACECCA, EMILIA R (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Address;Agonist;anti-PD-1;Antitumor Response;Binding;Biological Assay;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Separation;Cells;Clinical;Coculture Techniques;cohort;combat;conditional knockout;cytokine;Cytokine Signaling;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;cytotoxicity;Data;exhaustion;Exhibits;experimental study;extracellular;Family;Family member;Fellowship;Flow Cytometry;Frequencies;Functional disorder;Future;Genetic Transcription;Goals;Granzyme;Human;IL4 Signaling Pathway;Immune;immune checkpoint;immune checkpoint blockade;Immune system;Immunotherapy;improved;In Vitro;in vivo;Individual;Individual National Research Service Award;Infiltration;inhibitor;Injections;Interferon Type I;Interferon Type II;Interleukin-4;Kinetics;knock-down;Knock-out;Knockout Mice;Link;Malignant Neoplasms;MC38;MCF7 cell;Measures;Messenger RNA;Minority;Mitogen-Activated Protein Kinases;Molecular;Mus;neoplastic cell;neutralizing antibody;new therapeutic target;novel;Nuclear;nucleofection;Oncology;Outcome Measure;overexpression;Pathway interactions;Patients;Peripheral;Phenotype;Phosphoric Monoester Hydrolases;Play;pre-doctoral;Proliferating;promoter;Protein Kinase;Regulation;Reporting;resilience;Resistance;responders and non-responders;response;Reverse Transcription;RNA Interference;Role;screening;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Specificity;success;T cell response;T-Lymphocyte;Testing;Therapeutic;therapeutic target;transcription factor;transcriptome sequencing;treatment response;trend;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Western Blotting;Work

PROJECT_TITLE: DUSP2 in Negative Regulation of Cytotoxic T Cell Responses to Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative Argasid ticks are a significant yet understudied vector of disease-causing pathogens. Defining the molecular interactions between the argasid vector and tick-borne relapsing fever spirochetes will lead to novel interven- tions that interrupt the disease’s life cycle.

PI_NAMEs: LOPEZ, JOB E (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Acinus organ component;anti-microbial peptide;Area;Bacteria;Binding;Borrelia;Borrelia turicatae;Cessation of life;Collection;comparative;Cysteine;Data;Defensins;Developed Countries;Developing Countries;differential expression;Disease;Disease Vectors;Disparate;Emerging Communicable Diseases;Environment;environmental stressor;Event;Experimental Models;Family;Fever;field study;functional genomics;Future;Gene Expression;Genes;Genetic Transcription;Genome;Genomic approach;Goals;Immune;Immune response;Immunity;Immunologics;improved;Incidence;Infectious Diseases Research;Insecta;Interruption;Intervention;Ixodidae;Knowledge;Laboratories;Life Cycle Stages;Measures;Mediating;Microbe;microbial;microbicide;Midgut;Mission;Modeling;Molecular;Molting;National Institute of Allergy and Infectious Disease;Nausea;non-Native;novel;Order Spirochaetales;Ornithodoros;pathogen;Pediculus humanus humanus;Peptides;Periodicity;Physiological;pressure;Property;Proteins;Public Health;Quantitative Reverse Transcriptase PCR;Reaction;Recurrence;Relapsing Fever;relapsing fever borrelia;Reporting;Resistance;response;Role;Salivary Glands;Specificity;Spontaneous abortion;System;Testing;tick transmission;Tick-Borne Relapsing Fever;Ticks;Tissues;transcriptome;transcriptomics;transmission process;vector;vector competence;vector tick;vector-borne;Vomiting

PROJECT_TITLE: Delineating adaptive mechanisms of tick-borne relapsing fever spirochetes within the argasid vector.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-U (02)]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Data Science;Diabetes;Digestive Diseases;Kidney Disease;Networking and Information Technology R&D (NITRD)

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative In order to assist in navigating the growing resource information landscape and utilizing available tools and resources we will build on the foundation provided by dkNET to provide tools and services to researchers, clinicians, funders, and publishers. Specifically, we will support resource discovery and selection, improving rigor and reproducibility, assisting in ensuring data are published in a FAIR manner, and providing the NIDDK research community with a novel AI/ML computational platform.

PI_NAMEs: CHEN, SHUIBING ;GRETHE, JEFFREY S. (contact);LI, CHEN ;WANG, WEI

PROGRAM_OFFICER_NAME: XIA, ASHLEY

PROJECT_TERMS: Adoption;Area;base;big data management;Big Data Methods;Bioinformatics;bioinformatics tool;biomedical resource;Cloud Computing;Communities;community engagement;Community Outreach;computational platform;computing resources;Data;Data Aggregation;data integration;data mining;data modalities;data reuse;Data Science;Data Set;data sharing;data tools;Development;Diabetes Mellitus;Digestive System Disorders;Education;Educational Materials;Elasticity;Ensure;Evaluation;FAIR principles;Feedback;Fostering;Foundations;Generations;Goals;Growth;improved;Information Networks;Kidney Diseases;Knowledge;knowledge of results;Lead;Leadership;Mission;Modality;Modeling;natural language;Natural Language Processing;next generation;novel;Organism;Organoids;outreach;Phase;Process;programs;Protocols documentation;Publishing;Reagent;Recommendation;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Science;Series;Services;Site;skills;sound;Source;stem cells;Students;success;Techniques;tool;Training;Validation;webinar;Work

PROJECT_TITLE: dkNET Coordinating Unit: Harnessing the Power of AI and Data Science forCollaborative Discovery and Sharing in the DK Community

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-2 (O3)]


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Food Allergies;Genetics

PHR: NARRATIVE Remodeling of the esophagus is a serious issue driven by a variety of food- and aero-allergens that affects the wellbeing of up to 1 in 1000 people and with an estimated healthcare cost of $1 billion. Defining proteins that drive or contribute to esophagus remodeling, fibrosis, and esophageal smooth muscle dysmotility, may lead to new treatment options for these patients. This proposal will test the hypothesis that the extracellular proteins LIGHT/TNFSF14 and TWEAK/TNFSF12 interact with one another as well as IFN and IL-13 to promote structural changes in the esophagus that result in rigidity and strictures which in turn cause issues with swallowing and food consumption.

PI_NAMEs: ACEVES, SEEMA S (contact);CROFT, MICHAEL

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adult;Affect;airborne allergen;Allergens;Allergic;Allergic Disease;Animals;Antigens;Atopic Dermatitis;Biopsy;CCL11 gene;CCL2 gene;Cells;Chemotactic Factors;Child;Chronic;Clinical;Complex;cytokine;Data;Deglutition;Deglutition Disorders;Dependence;Desire for food;Diet;Disease;Disease Resistance;Endoscopy;eosinophil;Eosinophilic Esophagitis;Esophageal Tissue;Esophagitis;Esophagus;Exhibits;Extracellular Protein;Failure to Thrive;Family member;feeding;Fibroblasts;Fibrosis;Food;food consumption;Foundations;Functional disorder;Gene Expression;Genes;Genetic Transcription;Grant;Health Care Costs;high voltage electron microscopy;Human;Immune;immune activation;imprint;In Vitro;in vivo;Incidence;indexing;Infiltration;Inflammation;Inflammatory;Interleukin-13;knock-down;Light;LIGHT protein;Longitudinal cohort;Measures;Mediating;member;Modeling;Monitor;monocyte;motility disorder;mouse model;Mus;muscle hypertrophy;Myelogenous;Myofibroblast;new therapeutic target;novel;Oral;Organ;Pathogenicity;Patients;periostin;Personal Satisfaction;Persons;Phenotype;pre-clinical;preclinical study;Prevalence;Proliferating;Property;protein expression;Proteins;Psoriasis;Pyroglyphidae;RANTES;receptor;recruit;Recurrence;Research Personnel;response;Role;Sequential Treatment;Severities;Signal Transduction;single-cell RNA sequencing;skin disorder;Smooth Muscle;synergism;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapeutic target;Tissue Procurements;Tissues;TNF gene;Topical Corticosteroids;Transcript;transcriptome;transcriptomics;Vomiting

PROJECT_TITLE: TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodeling

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-B (57)]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Orphan Drug;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ENYX THERAPEUTICS, LLC

PHR: Narrative. Hereditary angioedema (HAE), a potentially life-threatening hereditary disorder associated with recurrent attacks of swelling of cutaneous tissues, intestinal tract and airways, is caused by mutations in the SERPING1 gene coding for C1 esterase inhibitor (C1EI). In a mouse model of HAE, gene therapy with an adeno-associated virus coding for C1EI (AAVrh.10hC1EI) reversed the swelling phenotype. This study focuses on assessing the safety of AAVrh.10hC1EI in nonhuman primates.

PI_NAMEs: CRYSTAL, RONALD G (contact)

PROGRAM_OFFICER_NAME: MINNICOZZI, MICHAEL

PROJECT_TERMS: Acute;Androgen Analogues;Angioneurotic Edema;Asphyxia;autosome;Biotechnology;Blood Vessels;Bradykinin;Bradykinin Receptor;Capsid;Cessation of life;Clinic;Code;Collaborations;Complement;Complement 1 Inactivators;complement system;Complementary DNA;Consumption;cost;CRISPR/Cas technology;Data;Dependovirus;Disease;Dose;Dyes;Edema;Endothelium;Extracellular Space;Extravasation;Female;Functional disorder;functional restoration;Gastrointestinal tract structure;gene therapy;gene transfer vector;Generations;Genes;Genetic;Goals;hereditary angioneurotic edema;Hereditary Disease;Histologic;Human;Immunity;in vivo;inhibitor;Intestines;intravenous administration;Kininogenase;Laboratories;Life;male;Mediating;Medical;mortality risk;mouse model;Mus;Mutation;National Institute of Allergy and Infectious Disease;Nature;nonhuman primate;Organ;overexpression;parenteral administration;Phase;Phenotype;Plasma;Plasma Kallikrein;Prekallikrein;prevent;Prophylactic treatment;Proteins;Recurrence;respiratory;Respiratory Mucosa;Respiratory System;Risk;Safety;safety assessment;Serine Proteinase Inhibitors;Serum;Skin Tissue;Small Business Technology Transfer Research;Surface;Swelling;System;Technology;Testing;Therapeutic;translational therapeutics;Translations;Vascular Permeabilities;Vasodilation;vector

PROJECT_TITLE: Safety of AAV-mediated C1 Esterase Inhibitor Gene Therapy for Hereditary Angioedema

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: WEATHERWAX BIOTECHNOLOGIES CORPORATION

PHR: NARRATIVE Triple-negative breast cancer (TNBC) accounts for about 20% of all breast cancer cases and is associated with poor prognosis and non-responsiveness to hormone and other targeted therapies. There is no standard care plan for TNBC and thus there is a critical need to find new and effective targeted therapies for TNBC. Weatherwax is proposing to develop bifunctional molecules to restore p53 activity, a tumor suppressor found mutated in the vast majority of TNBC cases, as a novel therapeutic opportunity for this aggressive breast cancer subtype, affecting approximately 200,000 individuals every year.

PI_NAMEs: COGNETTA, ARMAND  (contact)

PROGRAM_OFFICER_NAME: POND, MONIQUE ADRIANNE

PROJECT_TERMS: advanced breast cancer;Affect;Affinity;aggressive breast cancer;aggressive therapy;Antibodies;Automobile Driving;Binding;Binding Proteins;Biological;Biological Assay;Biology;Biotechnology;Breast Cancer cell line;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Prognosis;cancer subtypes;Cell Death;Cell Death Induction;Cell Line;Cessation of life;Chemicals;Chemistry;chemotherapy;Chronic Myeloid Leukemia;Classification;design;Development;Disease;Disease Outcome;Distant Metastasis;Dose;drug discovery;Drug Modulation;drug standard;Drug Targeting;early screening;Enzymes;Epidermal Growth Factor Receptor;Estrogen Receptors;Estrogens;Genes;Genetic;Grant;Homeostasis;Hormonal;Hormones;Human;Imatinib;Immunoprecipitation;Impairment;improved;In Vitro;Individual;ineffective therapies;Inherited;innovation;interest;Knock-out;Knowledge;Lead;lead optimization;leukemia;Libraries;Ligands;Link;Literature;Local Therapy;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Missense Mutation;Molecular;Molecular Conformation;mortality;mutant;Mutate;Mutation;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutics;Operative Surgical Procedures;overexpression;Pathway interactions;Pharmaceutical Chemistry;Phenotype;PMAIP1 gene;PML-RARalpha protein;Post-Translational Protein Processing;Pre-Clinical Model;preclinical study;Predisposition;Production;Progesterone;Progesterone Receptors;Prognosis;Property;Protein Conformation;Protein Isoforms;protein protein interaction;Proteins;Radiation;Reaction;receptor;recruit;Recurrence;Relapse;Reporter;Research;restoration;Risk Factors;screening;small molecule;small molecule therapeutics;standard care;Structure-Activity Relationship;success;Survival Rate;Systemic Therapy;targeted treatment;Testing;Therapeutic;Therapeutic Index;therapeutic target;therapy design;Thermodynamics;tool;Toxic effect;TP53 gene;Trastuzumab;Tretinoin;triple-negative invasive breast carcinoma;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Woman;Work

PROJECT_TITLE: Development of Heterobivalent Small-Molecule Therapeutics for the Treatment of Triple-Negative Breast Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-G (10)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_NAME: PATCHCLAMP MEDTECH, INC.

ORG_STATE: WA

PHR: Narrative: Surgical perforations in the dura, the thick membrane of dense connective tissue surrounding the brain and spinal cord, require repair and sealing to prevent leakage of cerebrospinal fluid associated with serious complications such as infection, intractable headaches, or wound breakdown. Current dura repair methods such as suturing, stapling, grafts, and tissue adhesives are often ineffective at providing an immediate watertight clo- sure, resulting in poor outcomes and appreciable loss of time and money, including additional procedures and inpatient care to re-establish dural integrity. We address this problem with the PatchClamp surgical device to enable immediate watertight closure of the dura in either open or minimally invasive surgery, enabling the sur- geon ease and flexibility of application within restricted working space and access vectors, thereby reducing operating room time and expense and complications, substantial morbidity, and costs related to postoperative cerebrospinal fluid leakage.

PI_NAMEs: MAYBERG, MARC ROBERT (contact)

PROGRAM_OFFICER_NAME: AUBRECHT, TARYN GRACE

PROJECT_TERMS: 3D Print;Acute;Address;Animals;biomaterial compatibility;Brain;Calibration;care costs;Cephalic;Cerebrospinal Fluid;Cessation of life;Clinical Trials;clinically relevant;comparative efficacy;Complex;Consumption;cost;Coupling;cranium;Dense Connective Tissue;design;Development;Devices;disability;Dura Mater;efficacy testing;Elasticity;Extravasation;fabrication;Failure;Family suidae;FDA approved;Feedback;first-in-human;flexibility;Goals;grasp;Hand;improved;In Vitro;in vivo;in vivo evaluation;Infection;inpatient service;Intractable Headaches;Laceration;Laminectomy;Lateral;Length of Stay;Measurement;mechanical properties;Mechanics;Medical Device;meetings;Membrane;Methods;minimally invasive;Minimally Invasive Surgical Procedures;Modeling;Modification;Morbidity - disease rate;mortality;Movement;Nature;Neurosurgeon;neurosurgery;novel;Operating Rooms;Operative Surgical Procedures;Outcome;patch clamp;Perforation;Performance;Phase;poly(lactic acid);Polymers;Positioning Attribute;Postoperative Period;pre-clinical;Preparation;pressure;prevent;Procedures;prototype;Puncture procedure;Radial;Regulatory Pathway;repaired;Resolution;restoration;Rotation;seal;Secure;Shapes;skull base;Small Business Innovation Research Grant;soft tissue;Spinal Cord;Spine surgery;Structure;Surface;Surgeon;Surgical Clamps;Surgical incisions;Surgical sutures;Surgical Wound Dehiscence;Surveys;System;Techniques;Technology;Testing;Thick;Time;Tissue Adhesives;Tissues;tool;Training;vector;Vertebral column;Vision;Visualization;Work

PROJECT_TITLE: Novel device for the repair and sealing of dural perforations in minimally invasive surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-W (12)]


ADMINISTERING_IC: HS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: FAMILY MEDICINE

PHR: PROJECT NARRATIVE OVERALL The UCSD Learning Health Systems Science Center Core Grant will provide core services and resources to enhance the career development of embedded LHS Scientists to conduct research that will advance the field. These resources will be used to provide didactic and experiential education to LHS Scientists recruited broadly from UCSD and federally qualified health center community partners including the El Centro Regional Medical Center and the Family Health Centers of San Diego. The Center will foster collaboration among faculty from 8 academic departments in the School of Medicine, Economics, Biostatistics, the Altman Clinical and Translational Research Institute, Jacobs Center for Health Innovation, and Population Health Services to bring us closer to our goal of enhancing diversity of the LHS workforce and improving health and equity.

PI_NAMEs: HOGARTH, MICHAEL ;TAI-SEALE, MING  (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: UCSD Center for Learning Health Systems Science

STUDY_SECTION_NAME: Special Emphasis Panel[ZHS1 HSR-B (01)]


PI_NAMEs: TAI-SEALE, MING  (contact)

PROJECT_TITLE: Administrative Core


PI_NAMEs: CENE, CRYSTAL WILEY (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: HOGARTH, MICHAEL  (contact)

PROJECT_TITLE: RDAC


NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Urologic Diseases;Vaccine Related;Vector-Borne Diseases;Women's Health Research

ORG_NAME: PAI LIFE SCIENCES, INC.

PHR: PROJECT NARRATIVE A low-cost, effective vaccine for urogenital schistosomiasis would greatly aid in the fight against this debilitating disease. By producing a candidate vaccine antigen we intend to progress toward a commercial product leading to an improvement in global health.

PI_NAMEs: GRAY, SEAN ALEX (contact);MOLEHIN, ADEBAYO J

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Adolescent;Affect;Africa;Agonist;Amino Acids;Animal Model;Antibodies;Antigens;Biochemical;Catalysis;Cattle;Climate;Clinical Trials;co-infection;cost;Country;cross immunity;design;Development;Disease;Dose;efficacy clinical trial;egg;Exhibits;experience;Female genitalia;Fermentation;Fertility;fighting;Foundations;Funding;Future;genetic element;Genetic Recombination;Genitourinary system;global health;Good Manufacturing Process;Hamsters;hatching;Helminths;HIV;Human;Hybrids;Hydrophobicity;Immunization;Immunize;Immunoglobulin G;improved;Infection;infection rate;infection risk;Left;Length;Lesion;Life Cycle Stages;Malignant neoplasm of urinary bladder;Measures;Mediating;Modeling;next generation;nonhuman primate;novel;Orthologous Gene;Parasites;Persons;Pharmaceutical Preparations;Phase;Phase Ib Trial;phase II trial;Populations at Risk;Praziquantel;Praziquantel resistance;Predisposition;Prevalence;process optimization;Production;protein purification;Proteins;Protocols documentation;Recombinant Proteins;Recombinants;Reporting;Rodent;Safety;Schistosoma;Schistosoma haematobium;Schistosoma hematobium infection;Schistosoma mansoni;Schistosomiasis;Side;Signal Transduction;Small Business Technology Transfer Research;Southern Europe;Streptococcus bovis;Testing;Tissues;TLR4 gene;Toxicology;transmission process;Vaccine Antigen;vaccine candidate;vaccine evaluation;Vaccines;Vagina;Variant;Virulent;Woman

PROJECT_TITLE: Antigen and adjuvant selection for a vaccine against urogenital schistosomiasis, Hematoshield

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Data Science;Diabetes;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

PHR: PROJECT NARRATIVE Type 1 diabetes (T1D) is characterized by beta cell destruction in the pancreas where there currently are no preventions or cures. A wealth of data has been generated on the human pancreas by the Human Islet Research Network (HIRN) and other sources that can be used to understand T1D and identify biomarkers and therapies; however, these data are currently under-utilized by researchers. The proposed project will address this gap by creating a knowledge base ‘PanKBase’ consisting of a database of harmonized data in the pancreas and high- value summary resources created from these data, an analytical library of tools to extract knowledge from data and resources using statistical modeling and machine learning, an open science platform enabling all users to perform analyses and access data, and a robust engagement and outreach program.

PI_NAMEs: BURTT, NOEL P;FLANNICK, JASON ;GAULTON, KYLE JEFFRIE (contact);GLOYN, ANNA LOUISE;VOIGHT, BENJAMIN FRANKLIN

PROJECT_TERMS: Address;Alberta province;analytical tool;Area Analyses;Atlases;autoimmune pathogenesis;Automobile Driving;Awareness;Beta Cell;Biology;biomarker development;biomarker identification;cell type;Cells;cloud based;Code;Collaborations;Communities;community engagement;Community Outreach;complex data;Computational Biology;Computer software;computerized data processing;Custom;Data;data access;Data Aggregation;Data Analyses;data exploration;data harmonization;data quality;data resource;Data Science;Data Scientist;Data Set;data standards;Databases;Development;Diabetes Mellitus;digital platform;Disease;Disparate;Engineering;Ensure;Environment;experience;FAIR principles;Feedback;flexibility;Functional disorder;Generations;Genetic Risk;Genomics;Human;Immunology;improved;insight;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islets of Langerhans;Knowledge;knowledge base;knowledge integration;Knowledge Portal;Learning;Libraries;Machine Learning;machine learning model;Manuals;Modeling;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;novel;novel marker;open data;outreach;outreach program;Pancreas;preservation;Prevention;Prevention strategy;Process;programs;Quality Control;Recording of previous events;repository;Reproducibility;Research;Research Personnel;Resources;Running;Science;Software Engineering;Source;Statistical Models;sugar;Time;Tissues;tool;Training;treatment strategy;user-friendly;Visualization;web portal;web services;Work;working group

PROJECT_TITLE: An interactive resource to generate and provide integrated knowledge of the human pancreas

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-J (O1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Narrative HSPB8-associated rimmed vacuolar myopathy is a novel disease that provides insight into the mechanism of myopathy resulting from disruption of the CASA autophagy complex. We hypothesize that trehalose, a modifier of autophagy will rescue the disease pathology resulting from HSPB8 mutations and improve muscle weakness.

PI_NAMEs: KIMONIS, VIRGINIA EUNICE (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: Address;Adipose tissue;Adverse effects;Aftercare;Age;Alleles;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Autophagocytosis;autosomal dominant mutation;autosome;Axon;BAG3 gene;Binding;Biochemical;Biopsy;Cell Line;Cell Nucleus;Cell Survival;Cells;Charcot-Marie-Tooth Disease;clinically relevant;Colchicine;Complex;CRISPR/Cas technology;Data;Defect;Disease;disease model;Distal;Distal Muscular Dystrophies;Evaluation;Excision;Family;Fibroblasts;Fibrosis;gain of function;gene product;Goals;Heat shock proteins;Heat-Shock Response;hereditary neuropathy;high-throughput drug screening;Histologic;Histology;Human Pathology;improved;In Vitro;in vivo;induced pluripotent stem cell;Inherited;insight;Knock-in Mouse;Limb structure;Mediating;member;Messenger RNA;misfolded protein;Molecular;Molecular Chaperones;Motor;mouse model;Mus;Muscle;Muscle Cells;muscle degeneration;Muscle Weakness;Muscular Atrophy;mutant;mutant mouse model;Mutate;Mutation;Myoblasts;Myopathy;Nerve Degeneration;Neurodegenerative Disorders;Neuromuscular Diseases;Neuropathy;novel;Oral Administration;overexpression;Parkinson Disease;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patients;Phenotype;preservation;protein aggregation;protein biomarkers;Protein Family;protein TDP-43;Proteins;proteostasis;Quality Control;sex;Stress;System;Testing;Translational Research;translational study;Translations;Trehalose;Vacuole;Variant;Wheelchairs

PROJECT_TITLE: Mechanistic and Translational Investigations of HSPB8-associated dominant rimmed vacuolar myopathy

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Bioengineering;Biomedical Imaging;Clinical Research;Dental, Oral, and Craniofacial Disease;Lung

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE  Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are the two most prevalent sinonasal diseases and have immense economic impact exceeding $35B/year. Overlooked as a source of morbidity, the disease burden of CRS and AR is comparable to congestive heart failure, chronic obstructive pulmonary disease, and Parkinson's disease. In this proposal, we will develop an imaging modality that establishes an objective means to gauge sinus health and the response to treatment, which in turn will aid scientists, clinicians, and industry professionals to better develop drugs, devices, and other therapies.

PI_NAMEs: CHEN, ZHONGPING  (contact);WONG, BRIAN

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Absenteeism;Adult;allergic airway disease;Allergic rhinitis;American;Anesthesia procedures;Antibiotics;Asthma;awake;Biomedical Engineering;Biophysics;Blood Pressure;Body System;burden of chronic illness;burden of illness;Catheters;Child;chronic back pain;Chronic Obstructive Pulmonary Disease;chronic rhinosinusitis;Cilia;Clinical;clinical application;clinical translation;Collaborations;Congestive Heart Failure;cost;Cystic Fibrosis;Data;design;design and construction;Development;Device or Instrument Development;Devices;Diagnosis;Discipline;Disease;Drug Delivery Systems;drug development;Drug Monitoring;Drug usage;economic cost;economic impact;Endoscopes;Endoscopy;Excision;experience;Failure;Frequencies;Functional disorder;Functional Imaging;General Anesthesia;Health;Health Expenditures;Heart Rate;Human;human subject;Image;Imaging Device;imaging modality;imaging system;Imaging technology;In Vitro;in vivo;in vivo imaging;in vivo imaging system;Industry;Inflammatory;innovation;Interferometry;Investigation;Knowledge;Lasers;Light;Link;Maps;Measurement;Measures;Medical;Methods;Microscope;minimally invasive;Modeling;Monitor;Morbidity - disease rate;Morphologic artifacts;mortality;Motion;Mucociliary Clearance;Mucous Membrane;National Institute of Biomedical Imaging and Bioengineering;Noise;Nose;Operating Rooms;operation;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Optics;Oryctolagus cuniculus;Outcome Measure;Parkinson Disease;Patient Outcomes Assessments;Patients;Pattern;Performance;Performance at work;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Phase;Physicians;Physiological;Physiology;Pilot Projects;Population;Prevalence;Primary Ciliary Dyskinesias;Property;Publishing;Quality of life;recruit;Reporting;Research;research clinical testing;Research Project Grants;Resolution;Respiration Disorders;Respiratory Mucosa;response;rhinosinusitis;Scanning;Scheme;Schools;Scientist;Series;Severity of illness;Sinus;Site;Source;Speed;Standardization;Structure;Structure of mucous membrane of nose;success;Surface;Surveys;Swab;System;Technology;Temperature;Testing;Therapeutic;Time;Tissue imaging;Tissue Sample;Tissues;Translating;treatment response;United States;virtual;Visual;Visualization;Work

PROJECT_TITLE: In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging Technology

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Principal Investigator: Lim, Kian, H PROJECT NARRATIVE This proposal aims at targeting a key regulatory switch of the innate immune pathway, the Interleukin-1 Receptor- Associated Kinase 4 (or IRAK4) as a novel therapeutic strategy in pancreatic cancer, based on recent findings from our lab. We will explore how signaling emanating from IRAK4 intersect with oncogenic KRAS signaling, investigate the global and immune-related role of IRAK4 in pancreatic cancer, and develop IRAK4 inhibitor- based immunotherapeutic regimen that can be translated into clinical trials.

PI_NAMEs: LIM, KIAN H (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: Acceleration;Biological Assay;Biology;Cancer cell line;cancer type;cell injury;chemokine;chemotherapy;Clinic;Clinical;Clinical Trials;combinatorial;Connective Tissue;cytokine;Cytotoxic agent;Data;Defense Mechanisms;Development;Disease;effective therapy;efficacy testing;Event;Fibroblasts;Fibrosis;Future;Genetic;Genetically Engineered Mouse;Goals;Growth;Human;IL1R1 gene;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vivo;Infiltration;inhibitor;innate immune pathways;insight;Invaded;IRAK4 gene;Knowledge;KPC model;KRAS oncogenesis;KRAS2 gene;KRASG12D;Ligation;Literature;LoxP-flanked allele;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical;microorganism;Mission;Mitogen-Activated Protein Kinases;mouse model;Mus;mutant;Myeloid-derived suppressor cells;Natural Immunity;Nature;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic tumorigenesis;Patients;pharmacologic;Pharmacologic Substance;Phospho-Specific Antibodies;Phosphotransferases;Positioning Attribute;pre-clinical;Principal Investigator;Production;Prognosis;Regimen;Reporting;Research;Resistance;Role;Signal Pathway;Signal Transduction;standard care;T cell response;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Time;Toll-like receptors;Transducers;Translating;translational impact;tumor;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenic

PROJECT_TITLE: IRAK4 AS A NOVEL IMMUNOTHERAPEUTIC TARGET IN PANCREATIC DUCTAL ADENOCARCINOMA


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Pancreatic Cancer;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE: Public Health Relevance: The aggregate incidence of GI cancers across the whole digestive tract is the highest of any organ system; re-imagining the GI tract as a single target organ provides the rationale to screen the most lethal GI cancers simultaneously. Biomarkers that discriminate GI cancers by anatomic site make this approach practical by efficiently directing the diagnostic evaluation of positive test results. The project is relevant to NIH mission by applying knowledge that might extend healthy life and reduce the burden of illness due to GI cancers.

PI_NAMEs: KISIEL, JOHN  (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Address;Adenocarcinoma;age effect;alcohol exposure;Alleles;Anatomy;Archives;Barrett Esophagus;Biological Assay;Biological Markers;Body mass index;Body System;Buffers;burden of illness;Cancer Control;Cancer Detection;cancer site;Case/Control Studies;Categories;Cessation of life;chronic pancreatitis;Classification;cohort;Colon;colon cancer patients;Colonoscopy;Colorectal;Colorectal Cancer;colorectal cancer screening;Confidence Intervals;cost effective;cost efficient;Data;design;Detection;Development;Diagnostic;disorder control;DNA;DNA Methylation;Duct (organ) structure;Early Diagnosis;Esophagus;Evaluation;FDA approved;Feces;Future;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;improved;improved outcome;Incidence;Inflammatory Bowel Diseases;Knowledge;Laboratories;Lead;Life;Literature;Longterm Follow-up;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Methylation;Mission;Modeling;Modification;Molecular;molecular sequence database;next generation sequencing;Non-Malignant;Non-Steroidal Anti-Inflammatory Agents;novel;Organ;Pancreas;pancreatic cancer patients;Patients;performance tests;Phase;Positive Test Result;preservation;Prevalence;public health relevance;Race;Recording of previous events;Reproducibility;research clinical testing;Sampling;screening;Screening for cancer;Sensitivity and Specificity;sex;Signal Transduction;Site;Specificity;stool sample;Technology;Testing;Time;Tissues;Tobacco;Training;United States National Institutes of Health;upper gastrointestinal cancer;Validation;validation studies

PROJECT_TITLE: Multi-site Gastrointestinal Cancer Detection by Stool DNA Methylation


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

PHR: NARRATIVE Clinical Pharmacology is the scientific discipline that addresses all aspects of human-drug interactions, including mechanisms of drug action and the mechanistic basis for individual variation in drug response. Clinical Pharmacology is undergoing rapid change with the integration of “multiple omics” science and modern computational techniques such as artificial intelligence and machine learning. The long-standing Mayo Clinic Clinical Pharmacology Training Program has embraced these advances and incorporated them into a Training Program designed to prepare healthcare professionals to contribute to our understanding of human drug interactions by the application of all of the tools of modern biomedical and computational science.

PI_NAMEs: WANG, LIEWEI  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Clinical Pharmacology;Grant;Training

PROJECT_TITLE: Training Grant in Clinical Pharmacology


NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Heterochromatin is a tightly packed form of DNA, mainly consists of genetically inactive satellite sequences and mobile element, and is associated with several important cell functions, including gene regulation, silencing of repetitive DNA or the protection of the integrity of chromosomes. Large fractions of the human genome consist of heterochromatin, including the Y chromosomes, centromeres, telomeres, or the Barr body, and altered heterochromatic states can impair normal gene expression patterns, leading to the development of different diseases. Competition between the opposing mechanisms of heterochromatin formation and active transcription can result in dysregulation of host genes and silenced repeats. We will use the model species Drosophila to investigate epigenetic conflicts on different Y chromosomes, which will help to understand how repressive chromatin states may interact with actively transcribed genes, and will help to develop therapeutic strategies that aim toward resetting the epigenetic state of dysregulated genes.

PI_NAMEs: BACHTROG, DORIS  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Age;autosome;Biological Assay;Catalogs;Cell Physiology;Centromere;ChIP-seq;Chromatin;Chromatin Conformation Capture and Sequencing;Chromatin Structure;Chromosomes;Code;Conflict (Psychology);cost;Data;density;Deterioration;Development;Disease;DNA;DNA Insertion Elements;DNA Transposable Elements;Drosophila genus;Elements;Epigenetic Process;Essential Genes;Euchromatin;Evolution;Expression Profiling;fitness;fly;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome resource;genomic locus;Heterochromatin;Hi-C;histone modification;Histones;Human Genome;Impairment;Libraries;life span;Link;Longevity;male;Modeling;Modification;Molecular;Mutation;nanopore;next generation sequencing;novel strategies;Older Population;Organism;Phenotype;Proteins;Repetitive Sequence;Resolution;Selfish Genes;sex;Sex Chromatin;Sex Chromosomes;single molecule;telomere;Testis;Therapeutic;Time;Tissues;Toxic effect;Transcriptional Silencer Elements;transcriptome sequencing;Work;Y Chromosome

PROJECT_TITLE: Heterochromatin and Toxic YChromosomes

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

PHR: PROJECT NARRATIVE Most studies of fear learning have focused on the excitatory connections involved in fear circuits and/or local inhibitory interactions, with no attention to the role of long-range GABAergic connections across regions. This proposal investigates the physiological and functional role of a novel inhibitory pathway from auditory cortex to the lateral amygdala. Elucidating the contribution of long-range cortical inhibition will provide new therapeutic targets for the treatment of anxiety disorders.

PI_NAMEs: APICELLA, ALFONSO J (contact);MUZZIO, ISABEL A.

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Affective;Amygdaloid structure;Anatomy;Animals;Anxiety;Anxiety Disorders;Area;Association Learning;Attention;Auditory;Auditory area;auditory pathway;awake;Axon;Behavior;Behavioral;Belief;biocytin;Brain;Calcium;cell type;Cells;Cerebellum;Characteristics;Communication;Corpus striatum structure;Dendrites;Discrimination;Distal;Electrophysiology (science);Elements;Emotional;Ensure;Extinction;extracellular;Fright;Functional disorder;Gene Expression;Genetic;genetic approach;Glutamates;Goals;Head;hippocampal pyramidal neuron;Image;in vivo;Individual;insight;Interneurons;Knowledge;Label;Lateral;Learning;Mediating;microendoscope;multisensory;Mus;neglect;neural circuit;Neurons;neuropathology;new therapeutic target;novel;optogenetics;Output;Parvalbumins;patch clamp;Pathway interactions;Phobias;photoactivation;Physiological;Play;Population;Positioning Attribute;Property;Psychopathology;reconstruction;recruit;Research;response;Retrieval;Reverse Transcriptase Polymerase Chain Reaction;Role;selective expression;sensory input;Signal Transduction;Social Interaction;Somatostatin;sound;Stains;success;Synapses;Testing;tool;transcriptome sequencing;transmission process;treatment of anxiety disorders;Vasoactive Intestinal Peptide;Viral;Work

PROJECT_TITLE: The role of cortical long-range GABAergic inhibition on emotional learning

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Osteogenesis Imperfecta;Pediatric;Rare Diseases

ORG_CITY: FARMINGTON

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: PROJECT NARRATIVE  These investigations will clarify the mechanisms responsible for a syndrome causing skeletal fragility and fractures. The proposed work will serve to establish the function and mechanisms of activation of an important gene mutation. The work will enhance our understanding of genetic disorders affecting the skeleton.

PI_NAMEs: CANALIS, ERNESTO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Affect;Affinity;Antibodies;Binding;Binding Proteins;Biological;bone;bone fragility;bone loss;bone mass;Bone remodeling;Cell Lineage;Cell Physiology;Cells;Child;Diagnosis;Disease;disease-causing mutation;Drosophila genus;effective intervention;Enhancers;Epidermal Growth Factor;Exhibits;Exons;experimental study;Extracellular Domain;Family;Female;Fracture;functional outcomes;gain of function;Gene Mutation;Genes;Genetic;Genetic Diseases;Goals;Guidelines;Human;human disease;Investigation;Knowledge;Ligands;Membrane;Modeling;Molecular Abnormality;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;notch protein;Notch Signaling Pathway;NOTCH1 gene;NOTCH3 gene;novel;Nuclear Proteins;Osteoblasts;Osteoclasts;Osteogenesis Imperfecta;Osteopenia;Pathogenesis;Pathway interactions;Phenotype;Play;Positioning Attribute;prevent;receptor;Regulation;Reporting;Research;Role;Signal Pathway;Signal Transduction;skeletal;skeletal disorder;Skeleton;substantia spongiosa;Syndrome;Testing;Work

PROJECT_TITLE: A NOTCH2 Mutation Causes Osteogenesis Imperfecta

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: NARRATIVE A dietary assessment approach that reduces participant and researcher burden and improves recall accuracy and ecological validity is needed to move the field forward. In response, we propose to develop and test a low cost mobile app that uses ecological momentary assessment to collect dietary data with limited burden and notable accuracy. Our approach will be additionally unique from traditional dietary assessment approaches in that it can be easily adapted for use as a dietary behavior change tool.

PI_NAMEs: SCHEMBRE, SUSAN  (contact)

PROGRAM_OFFICER_NAME: REEDY, JILL

PROJECT_TERMS: Address;Adult;Age;American;American diet;assessment application;behavior change;Beverages;Categories;Cessation of life;Cognitive;Computer software;Consumption;cost;Cross-Over Studies;Data;design;Diet;dietary;Dietary Assessment;dietary guidelines;Dietary intake;Dietary Intervention;Disease;Eating;Ecological momentary assessment;Energy Intake;Environment;Ethnic Origin;Event;Fatigue;Feedback;feeding;Food;Frequencies;fruits and vegetables;Future;Gender;Goals;Image;improved;Intake;Internet;Intervention;Interviewer;Measures;Memory;men;Methods;minimally invasive;mobile application;mobile computing;Modeling;National Health and Nutrition Examination Survey;Notification;novel;Nutrient;Outcome Measure;Participant;Pattern;Persons;Population Heterogeneity;Premature Mortality;prevent;prototype;Psychosocial Factor;Public Health;Questionnaires;Race;Randomized;Recommendation;Reporting;Research;Research Personnel;response;Response Latencies;Sampling;satisfaction;saturated fat;smartphone application;smartphone based assessment;social;Sodium;Source;sugar;Surveys;Taxes;Technology;Testing;Time;tool;Translating;Update;usability;user centered design;Visual;Woman;Work

PROJECT_TITLE: Mobile Ecological Momentary Diet Assessment: A Low Burden, Ecologically-Valid Approach to Measuring Dietary Intake in Near-Real Time

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Despite the use of anti-viral drugs, HIV remains a chronic infection that decreases normal lifespan. Curing HIV+ individuals is a top priority. We will test a new therapy in SIV-infected non-human primates, that targets virus in both lymph nodes and the intestines to eliminate virus from the areas it is most commonly found. This may be a cure strategy for HIV+ people.

PI_NAMEs: SKINNER, PAMELA J (contact);VEZYS, VAIVA D

PROGRAM_OFFICER_NAME: NGUYEN, KHOA DINH DANG

PROJECT_TERMS: Animals;Anti-Retroviral Agents;Anti-viral Agents;anti-viral efficacy;antiretroviral therapy;Area;Autologous;B-Lymphocytes;Biological Response Modifiers;CCR9 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cells;chimeric antigen receptor T cells;chronic infection;combinatorial;Combined Modality Therapy;Control Animal;Data;Disease remission;engineered T cells;Goals;Gut associated lymphoid tissue;HIV;HIV Infections;HIV therapy;HIV-1;Homing;Human;Human immunodeficiency virus test;Immunotherapy;In Vitro;in vivo;Individual;Infection;Interruption;Intervention;Intestinal Mucosa;Intestines;life span;Location;lymph nodes;Lymphoid Follicle;Lymphoid Tissue;Macaca;Macaca mulatta;Methods;migration;Mucous Membrane;Myeloid Cells;nonhuman primate;novel therapeutics;Persons;Pharmacotherapy;Phenotype;RNA;SIV;Source;T cell response;T-Lymphocyte;Testing;Time;Tissues;Viral;Viral Load result;Viral Physiology;viral rebound;Viral reservoir;viral RNA;Viremia;Virus;Virus Replication;Work

PROJECT_TITLE: Targeting HIV-specific CAR T cells to the gut for the durable remission of HIV


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The indications for glaucoma drainage device (GDD) implantation have expanded over time due to its excellent intraocular pressure (IOP) control. However, one of the major long-term complications associated with GDDs is progressive corneal endothelial cell loss (ECL) leading to corneal decompensation. Here we propose a multi-center randomized clinical trial to evaluate two tube placements in preventing ECL after GDD implantation, with the goal of the study to identify better surgical approaches to decrease postoperative corneal complications while preserving control of IOP.

PI_NAMEs: HAN, YING  (contact);ROSE-NUSSBAUMER, JENNIFER

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Address;American;Anterior;anterior chamber;aqueous;Biological Markers;Blindness;California;Caring;Cell Density;cellular imaging;Chronic;Ciliary Body;Clinical;cohort;comparison control;Complex;Cornea;Corneal Endothelium;Data;Data Coordinating Center;deep sequencing;design;Devices;Drainage procedure;Endothelial Cells;Eye Movements;Foundations;Funding;Future;Gene Expression Profile;Glaucoma;Goals;Health;high resolution imaging;Image;Imaging Techniques;implantation;improved;Inflammation;innovation;interest;Investigation;Iris;Location;Longitudinal Studies;Masks;Mechanics;Medical;Metagenomics;Nature;novel;Operative Surgical Procedures;Ophthalmology;Optics;Outcome;Participant;Patients;Pennsylvania;Pharmaceutical Preparations;Physiologic Intraocular Pressure;Pigments;Positioning Attribute;Postoperative Complications;Postoperative Period;preservation;prevent;Prospective Studies;Randomized;randomized, clinical trials;Reading;Refractory;Retrospective Studies;RNA;Sampling;San Francisco;Silicones;Societies;Specialist;surgery outcome;Surveys;Techniques;Time;Touch sensation;trial comparing;Tube;Universities;Visual Acuity

PROJECT_TITLE: Glaucoma Drainage Device and Endothelial Cell Density Loss Compare (DECLARE) Trial


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Physical Activity

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Repeated exercise has beneficial effects on the brain and body and has been shown to reduce the progression of neurodegenerative diseases such as Alzheimer's disease (AD). We have found that artificial stimulation of a specific set of exercise-responsive neurons in the mouse hypothalamus modulates subsequent exercise endurance, but whether such stimulation can also generate the beneficial effects of exercise in the brain remains unknown. By leveraging new technologies that permit a detailed structural and functional deconstruction of this exercise-responsive circuit, our goal is to determine whether generating activity within this circuit promotes enhanced cognition and neuroprotection during aging and in AD.

PI_NAMEs: BLOSS, ERIK BRADLEY (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Anatomy;Architecture;Array tomography;Automobile Driving;behavior measurement;Brain;brain circuitry;cell type;Cells;Chemosensitization;Cognition;Cognitive;cognitive benefits;cognitive performance;Data;Development;Disease;early onset;endurance exercise;Exercise;Exertion;experience;experimental study;Functional Imaging;Genetic;Genetic Models;Goals;Health;Hypothalamic structure;Image;Imaging Techniques;Impaired cognition;improved;in vivo;in vivo calcium imaging;Individual;inflammatory marker;insight;Intervention;Knowledge;Label;Late Onset Alzheimer Disease;Logic;Maps;Measures;Mediating;Middle Hypothalamus;mouse model;Mus;Nerve Degeneration;neural;neural circuit;Neuroanatomy;Neurodegenerative Disorders;neuroinflammation;Neuronal Plasticity;Neurons;neurophysiology;neuroprotection;neuroregulation;neurotransmission;new technology;novel therapeutics;Output;Pattern;Physical Endurance;Physiological;Population;pre-clinical;protective effect;reconstruction;Recording of previous events;Research Personnel;Resolution;response;Risk Reduction;SF1;Shapes;Signal Transduction;Structure of paraventricular nucleus of thalamus;Structure of terminal stria nuclei of preoptic region;Synapses;Testing;Therapeutic;therapeutic target;tool;Training;transmission process;Viral;Work

PROJECT_TITLE: Deconstruction of a Hypothalamic Exercise-responsive Circuit for Neuroprotection

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Autoimmune Disease;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE AIRE is critical for maintaining central and peripheral tolerance to prevent autoimmune diseases but can also play a detrimental role in inhibiting immune responses against cancer. While deletion of thymic AIRE expression has been shown to improve immunotherapy response in certain cancers by allowing the development of autoreactive T cells, whether AIRE expression outside of the thymus is involved in regulating anti-tumor immune responses remains unknown. This proposal investigates the role of peripheral AIRE expression and AIRE-expressing tumor-associated macrophages in tumor progression and immunity with the ultimate goal of improving immunotherapy approaches for cancer treatment.

PI_NAMEs: GULDBERG, SOPHIA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: anti-CTLA4;anti-PD-1;anti-tumor immune response;Antibodies;Antigens;Antitumor Response;ATAC-seq;Autoimmune;Autoimmune Diseases;Autoimmunity;Automobile Driving;autoreactive T cell;Biological Assay;Biology;Bone Marrow;California;Cancer Etiology;cancer immunotherapy;cancer therapy;career;CD4 Positive T Lymphocytes;Cell surface;cell type;Cells;Cellular biology;central tolerance;Chromatin;Chromosome Mapping;Coculture Techniques;Cytometry;Data;Data Set;Development;Environment;Epigenetic Process;epigenomics;Equilibrium;Fellowship;Flow Cytometry;Frequencies;Funding;Gene Expression;gene function;gene induction;Generations;Genetic;Genetic Transcription;Goals;Health;Hematopoietic;Human;human RNA sequencing;Immune;immune activation;immune checkpoint blockade;Immune response;Immunology;immunoregulation;immunosuppressive macrophages;Immunotherapy;improved;In Vitro;in vivo;Institution;Investigation;ITGAM gene;Knock-out;knockout gene;Laboratories;Macrophage;Malignant Neoplasms;MC38;Melanoma;Mentorship;Methods;Modeling;mouse model;Mus;Mutation;Myeloid Cells;neoplastic cell;novel;novel therapeutics;Pathway interactions;patient response;Peripheral;peripheral tolerance;Phenotype;Play;Polyglandular Autoimmune Syndrome Type I;Population;prevent;programs;Regulation;Regulator Genes;Research;research and development;Research Project Grants;response;Role;San Francisco;secondary lymphoid organ;Signal Pathway;single cell analysis;single-cell RNA sequencing;skills;Solid Neoplasm;Stimulant;Syndrome;synergism;System;systemic autoimmunity;Testing;Therapeutic;therapy resistant;Thymic epithelial cell;Thymus Gland;Tissues;TNFRSF5 gene;TNFSF11 gene;TNFSF5 gene;tool;Training;transcriptome sequencing;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor-associated macrophages;Universities;Work

PROJECT_TITLE: Determining the role of AIRE and AIRE-expressing tumor associated macrophages in tumor growth and immunity


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative Anthracycline chemotherapeutic agents are commonly used in cancer treatment but can cause heart failure (HF), with older adults at increased risk. HF after anthracycline therapy has a poor prognosis and thus strategies to prevent anthracycline cardiotoxicity are needed. The proposed research will develop and externally validate a multivariable risk prediction model for HF in older adults with lymphoma, determine the utilization patterns of cardioprotective medications in routine clinical practice and elicit patient and provider preferences for cardioprotective strategies to support future clinical trials of cardioprotection in older adults with lymphoma.

PI_NAMEs: UPSHAW, JENICA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: administrative database;Adult;Affect;Age;antagonist;Anthracycline;Apoptosis;cancer clinical trial;cancer risk;cancer therapy;Cardiac;Cardiac Myocytes;Cardiology;Cardiomyopathies;cardioprotection;Cardiotoxicity;cardiovascular effects;Cardiovascular system;career;career development;Cessation of life;chemotherapeutic agent;chemotherapy;Clinical;clinical practice;Clinical Practice Guideline;Clinical Research;clinical risk;Clinical Trials;Clinical Trials Design;comorbidity;Continuous Infusion;coronary fibrosis;Data;Data Set;Databases;design;Dexrazoxane;Diagnosis;Disease remission;experience;experimental study;Formulation;Funding;Future;Geography;Goals;Health Personnel;Health Policy;Health system;Heart Diseases;Heart failure;Hematological Disease;high risk;high risk population;human old age (65+);improved;improved outcome;Individual;informant;Infusion procedures;Interview;Iron Chelation;K-Series Research Career Programs;Knowledge;Life;Link;liposomal formulation;Liposomes;Logistic Regressions;Lung Diseases;Lymphoma;Malignant Neoplasms;Medical center;medical schools;Medicare;Mentors;Mentorship;Modeling;National Heart, Lung, and Blood Institute;Newly Diagnosed;Obesity;off-label use;older adult;older patient;Older Population;Oncology;oncology program;Outcome;Outcome Study;Outcomes Research;patient oriented;Patient Preferences;Patient risk;Patients;Pattern;Pharmaceutical Preparations;Physician Executives;Population;predictive tools;preference;Prevalence;prevent;Prevention;Primary Prevention;professor;Prognosis;Program Development;Provider;randomized trial;Recommendation;Regimen;Registries;Research;Research Methodology;Research Personnel;Risk;Risk Estimate;Risk Factors;risk prediction model;Role;routine practice;Science;SEER Program;skills;socioeconomics;Surveys;Testing;Toxic effect;Training;Universities;Validation;Variant;Work

PROJECT_TITLE: Prevention of Anthracycline Chemotherapy Cardiotoxicity

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Post-transcriptional regulation of gene expression by microRNAs is a critical contributor to neuronal development but identifying precise molecular mechanism has been challenging. In this proposal, we describe two novel ap- proaches that will permit investigating the functional consequences of de-repressing either an individual miRNA- target interaction or all interactions on a single target. We apply these approaches to understand how miRNAs instruct the developmental trajectory of cortical excitatory neurons.

PI_NAMEs: LIPPI, GIORDANO  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Ablation;Affect;autism spectrum disorder;Binding;Biology;Brain;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;CRISPR-mediated transcriptional activation;Data;derepression;design;Development;Disease;DNA;dosage;Engineering;Ensure;Evolution;Excision;excitatory neuron;Failure;gamma-Aminobutyric Acid;gene discovery;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Goals;In Vitro;in vivo;Individual;innovation;Knowledge;Light;Link;loss of function;Maps;Mediating;Messenger RNA;MicroRNAs;Modernization;Molecular;Morphology;Mutate;Neurobiology;Neurodevelopmental Disorder;neuron development;neuronal survival;Neurons;Neurosciences;novel;novel strategies;Phenotype;Play;Positioning Attribute;Post-Transcriptional Regulation;postnatal development;posttranscriptional;prevent;programs;Proteins;Regulation;Reporter;Repression;Research;Resolution;Role;Schizophrenia;Structure;Testing;Time;tool;Transcription Repressor;Transcriptional Activation;Transcriptional Regulation;transcriptomics;Translational Repression;Untranslated RNA;Work

PROJECT_TITLE: Beyond Transcription - microRNA Regulation of Neuronal Development

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Pancreatic Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative  The proposed research is relevant for patients with cancer because it will investigate how intra-tumor mitochondrial heterogeneity influences the response to chemotherapy. The project is relevant to the NIH/NCI mission because will improve patient outcomes, as it addresses fundamental questions about the mechanisms that underlie the poor response of pancreatic cancer to current treatments. Specifically, we anticipate that our research will have an immediate translational impact through the identification of new biomarkers that can be used to select patients who can benefit from targeting mitochondrial respiration preventing tumor relapse.

PI_NAMEs: VIALE, ANDREA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 3-Dimensional;Address;Aftercare;Animals;Architecture;Biological Markers;biomarker identification;Cells;Chemoresistance;chemotherapy;Clinical;clinical investigation;Clinical Trials;Complex;Data;design;Diagnosis;Disease remission;Drug resistance;Early Diagnosis;Ecosystem;epigenomics;Face;Foundations;gemcitabine;Genetic Variation;Genomics;Heterogeneity;Human;improved;in vivo;inhibitor;Invaded;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Mediating;Metabolic;metabolic phenotype;Mission;Mitochondria;mitochondrial therapeutics;Molecular;Molecular Profiling;mortality;Mutation;neglect;Neoplasm Metastasis;neoplastic cell;novel;Outcome;Paclitaxel;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic PDX models;Patient Selection;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Population;Prediction of Response to Therapy;prevent;Process;Prognosis;Relapse;Research;Resistance;Respiration;respiratory;response;Role;Shapes;Solid Neoplasm;standard of care;Survival Rate;Testing;Therapeutic;therapeutic development;therapy resistant;Tissues;transcriptomics;translational impact;treatment response;tumor;tumor heterogeneity;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Mitochondrial heterogeneity as the origin of chemoresistance in pancreatic cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: MIAMI

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE As flavor is one of the main drivers of ENDS epidemic among young people in the US, we propose to investigate the potential of menthol, compared to tobacco flavors to enhance users’ experience, puffing behavior, and toxicant exposure. This evidence will be critical to the FDA's ability to set ENDS products' regulatory standards to reduce their potential harm.

PI_NAMEs: MAZIAK, WASIM  (contact)

PROGRAM_OFFICER_NAME: MANDLER, RAUL N

PROJECT_TERMS: abuse liability;addiction;Address;Aerosols;Affect;Aldehydes;Back;Behavior;Biological Availability;Cardiovascular system;Cigar;Cigarette;Clinical;combustible cigarette;comparison group;Coughing;Country;craving;Crossover Design;Data;Dependence;Deposition;design;Diffusion;Electronic cigarette;Electronic Nicotine Delivery Systems;Epidemic;experience;Exposure to;Frequencies;Future;Gender;Inhalation;Intention;irritation;Laboratories;Liquid substance;Marketing;Measures;Menthol;Methods;Minority;Modeling;Nausea;Nicotine;nicotine exposure;Nicotinic Receptors;Outcome;Palpitations;Participant;Pattern;Perception;Persons;Pilot Projects;Plasma;Play;pod mods;Policies;Predictive Value;Property;public health relevance;Pulmonary Function Test/Forced Expiratory Volume 1;Race;recruit;Regulation;Research;respiratory;Respiratory physiology;Respiratory Signs and Symptoms;response;Risk;Robot;Role;satisfaction;Science;sex;Smoking;social media;Societies;Symptoms;System;Technology;Testing;Tobacco;tobacco flavor;tobacco products;tobacco regulatory science;Tobacco use;Toxic effect;toxicant;Toxicant exposure;United States;Withdrawal;Woman;Xerostomia;Youth

PROJECT_TITLE: The effect of menthol on ENDS users' dependence, respiratory, and toxicants emission outcomes


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: NARRATIVE  The proposed research explores the possibility of precisely estimating change in specific brain structures in individuals at early stages of neurodegeneration. Anchoring from recent developments in fast brain scanning techniques, we use a novel methodological approach that permits a tremendous increase in the precision of measuring change within a single person by repeatedly, safety, and efficiently scanning the brain over time. Demonstrating successful precision measurement within the individual will open opportunities to track therapeutic effects in small samples during early phases of development as well as allow for individualized estimates of neurodegeneration to be made dynamically within the same person. !

PI_NAMEs: BUCKNER, RANDY L (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Acceleration;Achievement;Affect;Age;Aging;aging related;Alzheimer's Disease;American;amnestic mild cognitive impairment;Amyloid beta-Protein;Anatomy;Atrophic;Base Sequence;Biological Markers;Brain;Brain imaging;Brain region;Brain scan;brain volume;cerebral atrophy;Clinic;Clinical;Clinical assessments;clinical translation;Clinical Trials;cognitive change;Data;Dementia;Development;Diagnosis;Disease;Early identification;Event;Focus Groups;Goals;Head;hippocampal atrophy;Hippocampus;Human;image reconstruction;imaging approach;Imaging Techniques;Impaired cognition;Individual;Joints;Machine Learning;Magnetic Resonance Imaging;Measurement;Measures;Medical Research;Memory impairment;Methodology;Modeling;Monitor;morphometry;MRI Scans;Nerve Degeneration;neuroimaging;Neurosciences Research;normal aging;novel;Pathology;Pattern;Persons;Phase;Positioning Attribute;pre-clinical;Primary Progressive Aphasia;Procedures;Progressive Aphasias;Protocols documentation;Proxy;rate of change;Research;Resolution;Safety;safety testing;Sampling;Scanning;secondary analysis;Semantics;Statistical Models;Stream;structural imaging;Structure;tau Proteins;Techniques;Testing;therapeutic development;Therapeutic Effect;Thick;Time;time interval;tool;treatment response;Unmarried person;Variant;Work

PROJECT_TITLE: Exploration of MRI measures of neurodegeneration within individuals over short intervals

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative: We will use invasive electrical stimulation in neurosurgical patient volunteers to manipulate phrase-structure building neural activity in language areas of the brain while subjects are trying to comprehend a sentence. By observing the resulting effect on behavior and neural activity recorded elsewhere in the brain, we hope to better understand how the brain comprehends grammatical relations in sentences, and use this to develop better treatments for language disorder patients who have grammatical difficulties.

PI_NAMEs: NELSON, MATTHEW JOHN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TITLE: Neurophysiological mechanisms of language comprehension

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Networking and Information Technology R&D (NITRD);Organ Transplantation;Patient Safety;Pediatric;Telehealth;Transplantation

ORG_CITY: OWINGS MILLS

ORG_NAME: EMOCHA MOBILE HEALTH, INC.

ORG_STATE: MD

PHR: Project Narrative / Public Health Relevance Few interventions have proven to be successful in promoting medication adherence and impacting short- and long-term posttransplant outcomes in adolescent heart transplant recipients. In the proposed SBIR Direct to Phase II (R44) project, we will examine several newly implemented technological and practical innovations within emocha Health Inc.’s DOT app (and intervention) designed to help adolescent patients track their medication-taking and feel supported by their transplant care team. Together with emocha, the proposed study will examine differences in patient- and caregiver-reported measures, factors related to scalability and potential of translation of the DOT intervention into routine clinical care, and long-term health and adherence patient outcomes.

PI_NAMEs: GUPTA, DIPANKAR ;SEIGUER, SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: EGERSON, D'ANDREA R

PROJECT_TERMS: Acute;Adherence;Adolescent;adolescent patient;aged;Behavior;Businesses;care coordination;Caregivers;Caring;Childhood;Chronic;Clinical;clinical care;Collaborations;Complex;Consent;Control Groups;COVID-19;design;Directly Observed Therapy;Dose;empowerment;Evaluation;evidence base;Exhibits;experience;Feedback;Florida;Goals;graft failure;group intervention;Health;Health Personnel;health related quality of life;Heart;Heart Transplantation;high risk;Hospitalization;improved;indexing;innovation;Intervention;intervention delivery;Measurement;Measures;medication compliance;medication nonadherence;member;mHealth;mhealth interventions;mobile application;Mobile Health Application;Monitor;mortality;National Heart, Lung, and Blood Institute;novel;organ transplant recipient;Organ Transplantation;Outcome;Participant;participant enrollment;Patient Compliance;patient engagement;Patient Monitoring;Patient-Focused Outcomes;Patients;Perception;Pharmaceutical Preparations;Phase;Population;Positioning Attribute;post intervention;post-transplant;Process;public health relevance;Quality of Care;Randomized;Randomized, Controlled Trials;recruit;Regimen;Reporting;Research;Research Priority;Safety;Sampling;Small Business Innovation Research Grant;Solid;study population;Technology;Therapeutic Intervention;Time;tool;translational potential;transplant centers;Transplant Recipients;Transplantation;trend;Universities;virtual;Youth

PROJECT_TITLE: Evaluation of a mobile app-based video Directly Observed Therapy (video DOT) intervention for medication adherence in pediatric heart transplant patients


FUNDING_MECHANISM: OTHERS

ORG_CITY: PITTSBURGH

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: The proposed work will investigate changes in brain signaling and cognitive functioning that support recovery from addiction, as well as use of pretreatment neurocognitive functioning to inform substance use treatment planning. Substance use disorders are prevalent amongst Veterans. Cocaine addiction, in particular, has been shown to complicate treatment of other high priority behavioral health problems in the Veteran population (e.g., PTSD, opioid addiction). While there are currently no approved medications to support recovery from cocaine addiction, research indicates that Contingency Management (CM) – a behavioral intervention for cocaine users – can be effective. However, individual responses are variable and long-term benefits are limited. This CDA will test a new model of how CM works by examining brain-based predictors and indicators of treatment response. Results will have immediate implications for measurement-based implementation of existing CM variants within the VA, supporting access to the version of CM that is best aligned with each Veteran's needs.

PI_NAMEs: FORSTER, SARAH E (contact)

PROJECT_TERMS: Abstinence;addiction;Affect;Aftercare;Area;Behavior assessment;behavior measurement;Behavior Therapy;Behavioral;behavioral health;Brain;brain based;Caring;Cessation of life;Clinical;clinical decision-making;Clinical Trials;clinically relevant;Cocaine;Cocaine Dependence;Cocaine use disorder;Cocaine Users;Cognitive;cognitive ability;cognitive control;cognitive function;Cognitive remediation;contingency management;Cost Measures;Data;Decision Making;Development;Diagnosis;Disease;Drug Screening;Drug Use Disorder;Effectiveness;Electroencephalography;Electrophysiology (science);Ethics;Evaluation;Event-Related Potentials;evidence base;financial incentive;Fostering;Future;Goals;Homelessness;Hospitalization;Impairment;implementation barriers;implementation cost;Imprisonment;improved;Incentives;Individual;Individual Differences;individual patient;individual response;Inherited;Intervention;Knowledge;Measurement;Measures;Mental Health;Methods;military veteran;Mind;Modeling;Motivation;neural;neuroadaptation;Neurocognitive;novel;Opiate Addiction;opioid use disorder;Outcome;Outpatients;Participant;Patient Self-Report;Pattern;Performance;Pharmaceutical Preparations;Pharmacotherapy;Post-Traumatic Stress Disorders;Predictive Analytics;predictive modeling;premature;Prize;Probability;Process;programs;Provider;Psychological reinforcement;Recovery;Recovery Support;recruit;Relapse;relapse prevention;Reporting;Research;response;reward anticipation;Rewards;scaffold;Self Efficacy;Self-control as a personality trait;service member;Services;Severities;Short-Term Memory;Signal Transduction;Site;substance use;Substance Use Disorder;substance use treatment;Targeted Research;targeted treatment;Testing;Thinking;Training;Translations;treatment as usual;Treatment Effectiveness;Treatment outcome;treatment planning;treatment response;Urine;Variant;Veterans;voucher;Work

PROJECT_TITLE: Electrophysiological Predictors and Indicators of Contingency Management Treatment Response


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE A novel class of oral nicotine pouches that contain a crystalized nicotine powder instead of tobacco leaves (so- called “tobacco-free” pouches) have rapidly increased in popularity, yet there is virtually no research to inform their regulation. The proposed project will utilize controlled human lab studies, web-based experiments, and advertisement surveillance methods to gain a holistic understanding of these novel oral nicotine pouches. Results will reveal product features and marketing tactics of novel oral nicotine pouches that influence perceptions, abuse liability, and use behavior among smokers and non-nicotine users (including youth) in order to inform FDA regulations of these emergent products.

PI_NAMEs: MORAN, MEGHAN BRIDGID;SPINDLE, TORY RICHARD (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: 20 year old;abuse liability;addiction;Address;Adult;Advertisements;Advertising;Affect;Area;authority;Behavior;Benefits and Risks;Cigarette;Cigarette Smoker;combustible cigarette;Data;Dependence;Descriptor;Dose;Electronic cigarette;European Economic Community;experience;experimental study;Flavoring;Fruit;Genus Mentha;Health Benefit;Human;Influentials;innovation;Interdisciplinary Study;interest;Marketing;Monitor;Nicotine;Nicotine Withdrawal;non-cigarette tobacco product;novel;Online Systems;Oral;Oral Tobacco;Participant;Perception;pharmacokinetics and pharmacodynamics;Plasma;Police;Policies;Population;Powder dose form;Predisposition;Public Health;Recording of previous events;Regulation;Research;Risk;Sales;Sampling;Smokeless;Smoker;smoking abstinence;snus;Surveillance Methods;Testing;Time;Tobacco;tobacco advertising;tobacco flavor;Tobacco Industry;tobacco products;tobacco regulation;tobacco-free;virtual;Withdrawal;Withdrawal Symptom;Youth

PROJECT_TITLE: Novel "Tobacco-Free" Oral Nicotine Pouches: The impact of Product Features and Marketing Influences on Abuse Liability, Perceptions, and Use Behavior in Smokers and Non-Nicotine Users