NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emergency Care;Health Services;Patient Safety;Pediatric;Prevention;Telehealth

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Emergency Medical Service (EMS) systems aim to provide safe, high-quality care to sick children in ambulances as a national priority. This proposal leverages existing data from a K23 award to develop a simulation-based patient safety assessment toolkit and intervention training that are needed to test if EMS providers using video technology (teleconsultation) from ambulances to communicate with pediatric expert physicians in hospitals can provide safer care when compared to usual care. If this strategy is acceptable, feasible, and produces measurably safer care in a realistic simulated environment, it would support future clinical trials of this innovative intervention with real children.

PI_NAMEs: BOYLE, TEHNAZ PARAKH (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Agreement;Ambulances;Applied Research;Assessment tool;Award;Blinded;Cardiopulmonary;Cardiopulmonary Resuscitation;career;Caring;Cessation of life;Child;Child Care;Childhood;Classification;Clinical;clinical application;Clinical Trials;cohort;Communication;Consensus;Consultations;cost;Critically ill children;Data;design;Education;Educational Intervention;Effectiveness;efficacy testing;efficacy trial;Emergency Care;Emergency medical service;Environment;Event;experience;feasibility testing;Feedback;Future;gaps in access;Goals;Harm Reduction;Heart failure;high risk;Hospitals;Human Resources;improved;improved outcome;In Situ;Individual;Infrastructure;innovation;Intervention;intervention effect;intervention refinement;Investments;Life;lung failure;Measurable;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Methods;mobile computing;models and simulation;Paramedical Personnel;Parents;Participant;patient safety;Patient-Focused Outcomes;Patients;pediatric emergency;Performance;Physician Executives;Physicians;Pre-hospitalization care;Preclinical Testing;Prehospital Emergency Care;primary outcome;Process;Protocols documentation;quality assurance;Quality of Care;Radio;Randomized Controlled Clinical Trials;Randomized, Controlled Trials;remote health care;Research;Research Infrastructure;Research Personnel;Research Priority;Resource-limited setting;respiratory;Risk;Safety;safety assessment;safety outcomes;Scientist;secondary analysis;service providers;Severities;simulation;skill acquisition;skills;Standardization;Stress;Structure;Surveys;System;Technology;teleconsultation;telehealth systems;Telemedicine;Telephone;Testing;Time;tool;Training;treatment arm;treatment as usual;trial comparing;underserved community;Video Recording;Work

PROJECT_TITLE: Developing an assessment toolkit and training for teleconsultation as an intervention to improve prehospital patient safety in children

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-K (O2)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is currently an incurable and debilitating disease whose pathologies begin to accumulate in the brain decades before cognitive symptoms appear, indicating the importance of identifying individuals who are at risk of developing AD earlier in the aging process when they are still cognitively unimpaired. The current project aims to characterize brain connectome-based biomarkers of cognitive changes in aging and vulnerability to AD in cognitively unimpaired individuals, and examine the role of social disadvantage in contributing to risk for cognitive decline and AD. Findings from this project would benefit public health by informing not only risk prediction of AD, but also the development of targeted intervention and therapeutic treatment to promote healthy aging and prevent AD.

PI_NAMEs: TANG, RONGXIANG  (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Address;African American population;Age-associated memory impairment;Aging;aging brain;aging process;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-42;Amyloid beta-Protein;Biological;Biological Markers;Biological Process;Brain;Brain Mapping;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;cognitive neuroscience;cognitive performance;cognitive testing;Communication;Computer Analysis;connectome;cost effective;Data Set;Deterioration;Development;Disease;Disparity population;Early identification;Ethnic Origin;Ethnic Population;Foundations;Future;Goals;Grant;Health;health disparity;healthy aging;Hispanic Populations;Impaired cognition;improved;indexing;Individual;Intervention;K-Series Research Career Programs;Light;Link;Longitudinal Studies;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mentors;Methodology;Methods;Mexican Americans;multimodal neuroimaging;Nerve Degeneration;Neurobehavioral Manifestations;neurofilament;neuroimaging;neuroimaging marker;Neurosciences;Not Hispanic or Latino;older adult;Pathology;Plasma;Population Heterogeneity;Positron-Emission Tomography;Prevalence;prevent;programs;Property;Public Health;Race;racial minority population;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;Role;segregation;social disparities;Socioeconomic Status;socioeconomics;tau Proteins;tau-1;Therapeutic;Training;Translating;Twin Studies;Variant;Vietnam;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Brain Connectomics of Cognitive Aging and Vulnerability to Alzheimer's Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: DK

ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Cystic Fibrosis;Diabetes;Lung;Nutrition;Prevention;Rare Diseases

ORG_CITY: ATHENS

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: NARRATIVE Bone disease is a concerning complication of cystic fibrosis (CF), since related fractures are associated with worsening pulmonary function and might contraindicate transplantation. Whereas genetic mutations leading to CF contribute to development of bone disease, diabetes and nutritional status are also theorized to be major contributors. Determining the effect of an anti-diabetes diet on bone health in people with CF, including underlying biological mechanisms, will help expand the evidence-base to support updated nutrition standards- of-care for reducing the burden of CF-related metabolic complications, namely diabetes and bone disease.

PI_NAMEs: KINDLER, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: EGGERMAN, THOMAS L

PROJECT_TERMS: Acute;Adult;Aging;Biological;Biological Assay;Biological Markers;Biology;biomarker validation;blood glucose regulation;bone;Bone Density;Bone Development;Bone Diseases;bone fragility;bone health;bone imaging;bone metabolism;Bone Resorption;bone turnover;C-terminal;Calories;Carbon;career;Caring;Center Core Grants;Clinical;Clinical Trials Design;Complication;Consumption;Cystic Fibrosis;cystic fibrosis related diabetes;Data;Development;Diabetes Mellitus;Diet;Diet Modification;dietary;Dietary Fiber;Dietary Intervention;Disease;DNA Sequence Alteration;Doctor of Philosophy;Dual-Energy X-Ray Absorptiometry;Educational workshop;effective therapy;Energy Intake;Energy Metabolism;evidence base;Fasting;Fatty acid glycerol esters;Food;Fracture;Funding;gastric inhibitory polypeptide receptor;glucagon-like peptide 1;Glucose;Goals;Grant;Guidelines;Heritability;high standard;Hour;imaging biomarker;improved;incretin hormone;Ingestion;innovation;insulin secretion;Intake;International;Journals;knowledgebase;Lead;Link;Long-Term Effects;Longitudinal Studies;Malnutrition;Mediating;meetings;Mentors;Metabolic;Methods;N-terminal;National Center for Advancing Translational Sciences;National Institute of Diabetes and Digestive and Kidney Diseases;novel;nutrition;Nutritional;Nutritional status;OGTT;Osteogenesis;Outcome;Pattern;Peripheral;Persons;Plasma;Population;prevent;Procollagen;programs;prospective;pulmonary function;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Personnel;Resolution;response;Risk;Scholars Program;Secure;Site-Directed Mutagenesis;stable isotope;standard of care;Statistical Methods;sugar;Technical Expertise;Testing;theories;Training;Translations;Transplantation;trial design;United States National Institutes of Health;Universities;Update;Work;Writing;X-Ray Computed Tomography

PROJECT_TITLE: Effects of an anti-diabetes diet on bone health in adults with cystic fibrosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Rare diseases affect 30 million individuals in the United States and are a serious public health concern. Due to low awareness of and lack of effective treatment options for rare diseases, patients undergo protracted journeys toward diagnosis and therapy, i.e., rare disease odysseys, that have significant medical, psychosocial, and economic consequences. The objective of this study is to develop statistical machine learning models aimed at shortening rare disease odysseys and a framework leveraging REDCap for implementation.

PI_NAMEs: SHYR, CATHY  (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: accurate diagnosis;Affect;application programming interface;Area;Award;Awareness;biomedical data science;biomedical informatics;Biometry;career;Characteristics;Clinic;Clinical;clinical phenotype;Competence;Complex;Consumption;cost;Custom;Cystic Fibrosis;Data;demographics;design;Development;Diagnosis;Diagnostic;diagnostic strategy;Differential Diagnosis;Disease;disease phenotype;Economics;effective therapy;Electronic Health Record;Ensure;Exercise;Face;Fast Healthcare Interoperability Resources;flexibility;gene therapy;Genetic;Genome;Genomics;Goals;Grain;Hemochromatosis;Human;implementation framework;improved;Individual;Informatics;Information Retrieval;Infrastructure;Knowledge;Learning;Life Style;Link;machine learning method;machine learning model;Manuals;Maps;Marfan Syndrome;Medical;Mentors;Mentorship;Modeling;Modernization;Natural Language Processing;novel;novel diagnostics;Ontology;open source;Outcome;Patients;personalized management;Phase;phenome;phenomics;Phenotype;Play;Positioning Attribute;Principal Investigator;psychosocial;Public Health;Rare Diseases;Reporting;Reproducibility;Research;Research Personnel;Risk;Role;Services;statistical and machine learning;System;Techniques;Therapeutic;Time;Training;treatment strategy;United States;United States National Institutes of Health;usability;Work

PROJECT_TITLE: Development and implementation of statistical machine learning methods to shorten rare disease odysseys

STUDY_SECTION_NAME: Special Emphasis Panel[ZLM1 AS-C (01)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Immunotherapy;Radiation Oncology;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Studies have shown that non-invasive focused ultrasound thermal therapies can induce immunogenic cell death in breast cancer, although the mechanisms are not well understood. This proposal will characterize focused ultrasound thermal therapies in a breast cancer mouse tumor model by quantifying the immune response and correlating this response to a magnetic resonance image-derived thermal dose biomarker. The results obtained by this study will provide critical information that will be immediately utilized to inform future clinical trials that investigate combining MRI guided FUS with immune checkpoint inhibitors for local and systemic tumor control.

PI_NAMEs: PAYNE, ALLISON  (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: 4T1;Abscopal effect;adaptive immune response;Adaptive Immune System;adaptive immunity;biological adaptation to stress;Biological Assay;Biological Markers;biomarker development;breast cancer diagnosis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;cancer clinical trial;cancer subtypes;CD8-Positive T-Lymphocytes;Cell Death;Cell Death Induction;Cell Maturation;cell motility;Cell surface;Cellular Stress;chemotherapy;Clinical;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Coagulative necrosis;combat;Combination immunotherapy;combinatorial;Combined Modality Therapy;conventional therapy;Cross Presentation;cytokine;cytotoxicity;Dendritic Cells;Disease-Free Survival;Dose;Environment;Enzyme-Linked Immunosorbent Assay;Flow Cytometry;Focused Ultrasound;Focused Ultrasound Therapy;Future;Harvest;Heat shock proteins;Histopathology;Human;Hyperthermia;Image;Immune;immune activation;Immune checkpoint inhibitor;Immune Evasion;Immune response;Immunofluorescence Immunologic;immunogenic cell death;immunological diversity;Immunotherapy;improved;individualized medicine;Infiltration;Institution;Kinetics;lymph nodes;Lymphoid Tissue;Magnetic Resonance;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Melanoma;Metastatic Neoplasm to the Lung;Methods;Modality;Modeling;Molecular;Molecular Chaperones;Monitor;Mus;Necrosis;Newly Diagnosed;Oncogenic;Pathway interactions;patient subsets;Patients;Pattern;Pharmaceutical Preparations;photothermal therapy;pre-clinical;preclinical study;Proteins;Quantitative Evaluations;Radiation;Radiation therapy;recruit;Recurrence;Research Personnel;Resistance;Resolution;response;side effect;small cell lung carcinoma;sonoporation;Stains;success;System;systemic toxicity;T cell infiltration;T-Lymphocyte;targeted treatment;Temperature;Thermal Ablation Therapy;Time;treatment optimization;triple-negative invasive breast carcinoma;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;Tumor Tissue;Tumor-infiltrating immune cells;Tumor-Infiltrating Lymphocytes;United States;Work

PROJECT_TITLE: Quantitative evaluation of focused ultrasound thermal therapy on immunogenic cell death in breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-X (O1)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative By elucidating a molecular pathway contributing to fibroblast pathogenicity in rheumatoid arthritis (RA), we hope that our research will impact patient care both diagnostically and therapeutically. First, our findings will provide therapeutic benefit by examining the potential role for targeting the Wnt pathway in RA and by helping to build a foundation for a new class of therapies that directly addresses stromal populations. Moreover, our investigation of Wnt signaling among early RA patients and patients who fail to respond to conventional therapies may lead to innovative strategies to categorize and identify patients who could benefit from targeted treatments.

PI_NAMEs: MUELLER, ALISA ANNE (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acceleration;Address;antagonist;Arthritis;Autoimmune Diseases;Bioinformatics;Biological Assay;Biology;bone;C57BL/6 Mouse;Cartilage;Categories;Cells;Chemosensitization;Chronic;Clinical;clinical phenotype;clinical training;conventional therapy;CRISPR/Cas technology;cytokine;Data;Degenerative polyarthritis;Development;Enhancers;Environment;Evaluation;experimental study;Fibroblasts;Fibrosis;Foundations;Future;Gene Expression Profile;genetic signature;Genetic Transcription;Goals;Harvest;Histologic;Homeostasis;Immunology;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;inflammatory marker;Inflammatory Response;inhibitor;innovation;intraperitoneal;Investigation;joint inflammation;joint injury;K/BxN model;knock-down;Lead;Ligands;Lymphocytic Infiltrate;Measures;Mediating;Medicine;Mentors;Mentorship;Mesenchymal;migration;Modeling;Molecular;mouse model;Mus;Nature;new therapeutic target;Pathogenicity;Pathology;Pathway interactions;Patient Care;Patients;pharmacologic;Phenotype;Population;Production;Proliferating;Proteins;Regulation;Research;response;Rheumatoid Arthritis;Rheumatology;Role;Sampling;Scientist;Serum;Signal Transduction;single cell technology;single-cell RNA sequencing;Small Interfering RNA;Stromal Cells;Synovial Cell;Techniques;technology platform;Therapeutic;Time;tissue regeneration;Tissues;Training;transcriptome sequencing;transcriptomics;WNT Signaling Pathway;Work

PROJECT_TITLE: Wnt signaling as a driver of pathogenic stromal inflammation in rheumatoid arthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative In clinical trials of drugs and other therapies to treat blinding diseases of the retina, the FDA’s official recom  mendation is to use functional assessment, as it is likely to provide earlier indications of their efficacy. In my lab we have discovered a novel way to measure neural function at the cellular level in the living, human retina (the optoretinogram), which may prove to be faster, less invasive, and more sensitive to neural dysfunction than existing methods. The goal of this grant is to study and improve the technology, and then demonstrate its ability to measure disease related dysfunction in patients.

PI_NAMEs: JONNAL, RAVI S. (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: 3-Dimensional;adaptive optics;Affect;age effect;Age related macular degeneration;Animal Model;Biochemical;Biochemical Process;Biological Assay;Biomechanics;Blindness;Brain;cell injury;Cells;Characteristics;Clinic;Clinical;clinical application;clinical imaging;Clinical Trials;Complex;Data;Data Analyses;Dependence;design;Development;Disease;disorder of macula of retina;Early Diagnosis;Electroretinography;Experimental Designs;Feedback;Functional disorder;Genetic Models;genetic testing;geographic atrophy;Goals;Grant;Health;Human;Image;improved;inherited retinal degeneration;interest;Interneurons;Lead;Light;Measurable;Measurement;Measures;Methods;Microscopic;Morphology;mouse model;Mutation;Natural experiment;Neuronal Dysfunction;Neurophysiology - biologic function;Noise;novel;Optical Coherence Tomography;Optics;Osmosis;Pathologic;Pathology;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Photons;Photoreceptors;Physiology;Property;Proteins;Public Health;Recommendation;Reproducibility;Resolution;response;Rest;Retina;Retinal Diseases;retinal neuron;Rod Outer Segments;Sampling;Secondary to;Sex Differences;Signal Transduction;Source;Stimulus;structural imaging;Techniques;Technology;Testing;Three-Dimensional Image;Tissues;tool;Transducin;Translations;Variant;Vertebrate Photoreceptors;Visual Acuity;Work

PROJECT_TITLE: Investigating fundamental properties and clinical applications of the optoretinogram


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: NARRATIVE Current antiretroviral therapy has failed to eradicate HIV-1, partly due to the persistence of viral reservoirs including CD4+ T lymphocytes, cells of the monocyte-macrophage lineage, and other central nervous system cells. We propose to use state-of-the-art gene editing technology to extend the field’s general knowledge and specifically improve our ability to develop broad- spectrum CRISPR-based treatments to target the vast spectrum of HIV quasispecies as an important next step in the development of strategies to potentially cure for HIV disease.

PI_NAMEs: SARIYER, ILKER KUDRET;WIGDAHL, BRIAN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Animals;antiretroviral therapy;Back;Bar Codes;Base Sequence;BCAR1 gene;Binding;Biodistribution;Bioinformatics;Biological;Biological Assay;Biology;Blood;Brain;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Central Nervous System;Cicatrix;Cloning;Collection;Complex;Computational Biology;computational pipelines;Coupling;Data;deep learning;delivery vehicle;design;Development;Disease;DNA;Double Strand Break Repair;effective therapy;Effectiveness;Enzymatic Biochemistry;Enzymes;Event;Excision;Explosion;Funding;gene editing technology;Gene Expression;gene-editing approach;Generations;Genes;Genetic Transcription;Genetic Variation;Genome;Guide RNA;HIV;HIV Genome;HIV Infections;HIV-1;Human immunodeficiency virus test;humanized mouse;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;innovation;insertion/deletion mutation;Knowledge;Legal patent;Lentivirus Vector;Link;Macrophage;Mediating;Microglia;Modeling;Molecular;monocyte;mouse model;Mus;Mutation;Nature;Nested PCR;nonhuman primate;novel;Outcome;Patients;Peripheral;Peripheral Blood Mononuclear Cell;Plasmids;prediction algorithm;Process;promoter;Provirus Integration;repaired;Reproducibility;Research;Resources;Ribonucleoproteins;Sampling;Shuttle Vectors;System;T-Lymphocyte;tat Protein;Technology;Testing;Tissue Sample;Tissues;tool;Training;treatment optimization;treatment strategy;Variant;vector;Viral;Viral Load result;Viral Physiology;Viral Proteins;Viral reservoir;Virus

PROJECT_TITLE: Broad-spectrum HIV gene editing strategies in peripheral and brain reservoirs

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT NARRATIVE MOFFITT CANCER CENTER SUPPORT GRANT Moffitt Cancer Center (Moffitt) is a free-standing 501(c)3 not-for profit institution that was founded by legal statute to address cancer needs in the area, the State of Florida, and beyond, with the singular mission “to contribute to the prevention and cure of cancer.” Fully informed by the cancer burden in our community and catchment area, guided by highly effective, driven and synergistic senior leadership and a rigorous research strategic plan, supported by outstanding institutional funding, and cultivated by its five research Programs that span the basic, population, data, and clinical sciences, Moffitt fosters exceptional cancer research that spans discovery to translation to the clinic, and that has the momentum to accelerate its scientific impact for decades to come. More specifically, Moffitt’s research has provided paradigm shifts in our understanding of the cancer ecosystem, has discovered and advanced new means to prevent, treat and cure some forms of cancer that have led to changes in clinical practice and national health policy, and which over the next award period will be further accelerated by investments in research focused on: 1) our catchment area; 2) health disparities; 3) immuno-oncology; 4) metabolism; 5) data science; and 6) cancer care, delivery, and implementation science.

PI_NAMEs: CLEVELAND, JOHN L. (contact)

PROGRAM_OFFICER_NAME: PTAK, KRZYSZTOF

PROJECT_TERMS: Acceleration;Address;Advisory Committees;anti-cancer research;Area;Award;Basic Science;Black Populations;Cancer Biology;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer epidemiology;cancer prevention;Cancer Research Project;care delivery;career development;Catchment Area;Cervix Uteri;Clinic;Clinical;clinical practice;Clinical Sciences;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;County;Data Science;design;Detection;Development;Doctor of Philosophy;Ecosystem;Education;education research;Elderly;Evaluation;Evolution;Exclusion;Faculty;Florida;Fostering;Foundations;Funding;Future;Grant;Growth;Health;Health behavior and outcomes;health disparity;Health Services Accessibility;High School Student;Hispanic Populations;HIV;Human Papilloma Virus-Related Malignant Neoplasm;Immunooncology;Immunotherapy;implementation science;improved;Incidence;Informatics;Infrastructure;Institution;inter-institutional;Intervention Trial;Investments;Journals;Leadership;Legal;Legal patent;Lung;Machine Learning;Malignant neoplasm of lung;Malignant Neoplasms;mathematical learning;Melanoma;member;Metabolism;Minority;Mission;Molecular Medicine;National Health Policy;next generation;oncology program;Oropharyngeal;Ovarian;Patients;Peer Review;Peer Review Grants;Persons;Policies;Population;Population Sciences;prevent;Prevention;programs;Protocols documentation;Publications;Publishing;Puerto Rican;recruit;Research;research and development;Research Infrastructure;Research Personnel;Research Training;Resource Sharing;rural dwellers;Science;Scientist;screening;Series;sociodemographic group;standard of care;Strategic Planning;Structure;Students;Training;Training and Education;Translations;treatment trial;Underrepresented Minority;Vulnerable Populations;Woman

PROJECT_TITLE: Moffitt Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: SPRINGER, BRIAN  (contact)

PROJECT_TERMS: Advisory Committees;Appointment;Area;Award;Budgets;Businesses;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Science;care delivery;Catchment Area;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communication;Community Health Education;Community Outreach;COVID-19;Data Science;Dedications;Development;education research;Electronic Mail;Ensure;Equity;Evaluation;Faculty;faculty support;Fostering;Funding;Funding Opportunities;Future;Goals;Grant;health disparity;Human Subject Research;Immunooncology;implementation science;improved;Information Technology;Infrastructure;innovation;instructor;Journals;Laboratories;Leadership;Malignant Neoplasms;meetings;member;Metabolism;Minority;Modeling;Monitor;Newsletter;operation;Pathway interactions;Peer Review;Performance;Philanthropic Fund;Planet Earth;Policies;Population;Positioning Attribute;Postdoctoral Fellow;Prevention;Process;programs;Publications;recruit;Report (document);Research;Research Support;Research Training;Resource Sharing;satisfaction;Science;Scientist;Signal Transduction;Strategic Planning;Structure;Therapeutic;Time;Training Activity;Training and Education;Translational Research;virtual;Vision

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

ORG_CITY: ALEXANDRIA

ORG_NAME: AMERICAN ASSOCIATION FOR DENTAL, ORAL, AND CRANIOFACIAL RESEARCH

ORG_STATE: VA

PHR: Project Narrative The American Association for Dental Research (AADR) aims to develop a national and sustainable mentoring and mentor training network with educational and interactive opportunities across the network, between mentors and mentees within and beyond the home institutions to support the development of a diverse cadre of dental, oral and craniofacial researchers. The AADR Mentoring an Inclusive Network for a Diverse Workforce of the Future (AADR ‘MIND the Future’) will engage mentor and mentees with the goal to guide individual career development as well as to improve the quality of mentoring at the home institution through dissemination of the lessons learned by mentors and mentees in the network to facilitate a diverse cadre of early career investigators in dental, oral and craniofacial research.

PI_NAMEs: DRAKE, DAVID RAY;FOX, CHRISTOPHER H (contact);IOANNIDOU, EFTHIMIA

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: American Dental Association;career;career development;Collaborations;Communication;craniofacial;Dental;Dental Research;Dental Schools;Development;Diverse Workforce;diversity and inclusion;Education;education planning;Educational Activities;Funding;Future;Goals;Historically Black Colleges and Universities;Home;improved;Individual;innovation;Institution;Interpersonal Relations;Mentors;Midwestern United States;Mind;National Institute of Dental and Craniofacial Research;Oklahoma;Oral;Personal Growth;Positioning Attribute;programs;Research;Research Personnel;Science;Strategic Planning;technique development;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: AADR Mentoring an Inclusive Network for a Diverse Research Workforce of the Future - MIND the Future.


NIH_SPENDING_CATS: Cancer;Pediatric

PI_NAMEs: WRIGHT, KENNETH LYNN (contact)

PROJECT_TERMS: Address;anti-cancer research;Applications Grants;Area;Biology;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;career;career development;Career Mobility;Catchment Area;Chemicals;Child;Clinical;clinical care;Clinical Sciences;Collaborations;Communities;community collaboration;Community Outreach;Data;Databases;Decision Making;Dedications;Development;Discipline;diversity and equity;Doctor of Philosophy;Education;education research;Educational Activities;Educational Needs Assessments;Electronics;elementary school;Ensure;Equity;Evaluation;experience;Exposure to;Faculty;faculty mentor;Fellowship;Fostering;Foundations;Funding;Goals;Grant;Growth;health equity;Health Occupations;Health Professional;improved;Infrastructure;innovation;Institution;instructor;inter-institutional;Malignant Neoplasms;Manuals;Mathematics;matriculation;Mentors;Mentorship;novel;Nursing Faculty;Oncology;operation;Outcome;Parents;peer networks;Peer Review;Population;Population Scientist Supplement (R25);Postdoctoral Fellow;Primary Schools;Process;Professional Competence;professional students;programs;recruit;Reporting;Research;research faculty;Research Personnel;Research Training;Role;skill acquisition;skills;Strategic Planning;Structure;Students;Surveys;synergism;Talents;teacher;Trainers Training;Training;Training Activity;Training and Education;training opportunity;tumor immunology;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: Cancer Research Training & Education Coordination


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Childhood Leukemia;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: Relapse is the major cause of death in patients with acute leukemia. We have developed the total marrow and lymphoid irradiation (TMLI) regimen to precisely direct radiation to areas of disease while sparing healthy organs; however, relapses are still common. This project is designed to provide improved tumor control and safe outcomes by discovering optimal dose escalation strategies and by developing methods to limit damage and destabilization to surrounding tissues.

PI_NAMEs: HUI, SUSANTA K (contact);WONG, JEFFREY Y

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: 18F-fluorothymidine;3-Dimensional;Acute leukemia;Acute Myelocytic Leukemia;Address;Adipocytes;Affect;Aftercare;Allogenic;Area;Biological;Bioluminescence;Biophysics;Biopsy;Blood;bone;Bone Marrow;Bone marrow biopsy;bone preservation;burden of illness;Cause of Death;cell killing;Cells;Cellularity;chemoradiation;Clinical;Clinical Trials;Complement;conditioning;Cues;design;Detection;Disease;Disease remission;disorder control;Dose;efficacy evaluation;Engraftment;Environment;Evaluation;experience;Exposure to;Extramedullary;Fatty acid glycerol esters;Funding;Generations;Global Change;Goals;Grant;hematopoietic stem cell self-renewal;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hybrids;Image;imaging modality;imaging system;Imaging technology;Immunocompetent;improved;Individual;insight;irradiation;Kinetics;Knowledge;Lead;leukemia;leukemia relapse;Leukemic Cell;lipid biosynthesis;Location;Luciferases;lymphoid irradiation;Magnetic Resonance Imaging;Marrow;Measurement;Measures;Mesenchymal Differentiation;Mesenchymal Stem Cells;Methodology;Methods;MLL-AF9;Modality;Monitor;mouse model;multidisciplinary;Multimodal Imaging;Mus;neoplastic cell;non-invasive imaging;Organ;Outcome;Paint;Pathologic;Pathology;Patients;Phase;Positron-Emission Tomography;preconditioning;preservation;Process;Progression-Free Survivals;prospective;Publications;Publishing;Radiation;Radiation Dose Unit;Recurrence;Recurrent disease;Red Marrow;Refractory;Regimen;Relapse;relapse patients;Reporting;Research Personnel;Residual state;response;Risk;Rodent Model;Role;Safety;Sampling;self-renewal;simulation;Site;skeletal;Skeletal bone;Skeletal system;Spatial Distribution;spatiotemporal;standard of care;Survival Rate;Therapeutic;Tissues;Toxic effect;Transplantation;Transplantation Conditioning;treatment planning;treatment response;tumor;Validation;Variant;Water;Whole-Body Irradiation;Work;Yellow Marrow

PROJECT_TITLE: Conformal Total Body and Marrow Irradiation for Leukemia

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This project will use genetic and pharmacological approaches to determine the role that gasdermin D plays in bone loss caused by inflammation, radiotherapy, and chemotherapy. Successfully execution of this project will have translational implications because findings from this research can be exploited to treat bone loss associated with pathological conditions.

PI_NAMEs: MBALAVIELE, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Ablation;Adverse effects;alcoholism therapy;antagonist;autoinflammatory diseases;Biochemical;bone;Bone Formation Inhibition;bone loss;Bone Marrow Transplantation;bone mass;Bone remodeling;Bone Resorption;bone turnover;cancer cell;Cell Death;Cell membrane;Cells;chemotherapy;Chemotherapy and/or radiation;Chronic;Clinical;conditioning;cytokine;Cytoplasm;Data;Development;differentiation in vitro;Disease;Disulfiram;Dose;drug discovery;Environment;extracellular;FDA approved;Fracture;Functional disorder;Genetic;Hematologic Neoplasms;IL18 gene;Immune;Immune response;In Vitro;in vitro activity;Inflammasome;Inflammation;Inflammatory;inflammatory bone loss;Interleukin-1;Interleukin-1 beta;Knockout Mice;Lipopolysaccharides;loss of function;Membrane;mouse model;Mus;Mutate;Osteoclasts;Osteolysis;Participant;Pathologic;Pathology;Periodicals;pharmacologic;Pharmacotherapy;Play;prevent;Procedures;Process;Production;Proteins;Radiation;Radiation therapy;radioresistant;Rare Diseases;recruit;Regimen;Research;response;Role;Rupture;Septic Shock;Signal Transduction;skeletal;Syndrome;Testing;tissue repair;Transplant Recipients;transplantation therapy;VDAC1 gene

PROJECT_TITLE: Role of gasdermin D in bone resorption

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: FLORES, ELSA R (contact)

PROJECT_TERMS: Address;Adopted;Animal Model;Back;Basic Science;Belief;Biochemical Pathway;Biological Markers;Biology;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer initiation;Cancer Model;cancer therapy;cancer type;Catchment Area;Cell model;Cessation of life;Clinic;clinical practice;Clinical Research;Clinical Trials;combat;Complex;computer scientist;data integration;design;Development;Direct Costs;Disease;Disparity;Drug resistance;dynamic system;Ecosystem;effective therapy;Evolution;Fostering;Funding;Future;Genetically Engineered Mouse;Goals;Grant;Growth;Human;human model;improved outcome;in silico;in vivo;Incidence;individual patient;innovation;interdisciplinary approach;lens;Lung;Machine Learning;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;mathematical model;Mathematics;Measures;Melanoma;member;Metabolic;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;New Agents;Pathway interactions;patient derived xenograft model;Patients;Peer Review;personalized medicine;predictive marker;Prevention;Prevention strategy;Process;programs;Publications;Publishing;recruit;Refractory;Relapse;Research;Resistance;response;Scientific Advances and Accomplishments;Signal Transduction;success;Therapeutic;Therapy Clinical Trials;therapy resistant;Translating;translational cancer research;translational pipeline;Translational Research;Treatment Failure;treatment response;treatment strategy;tumor;tumor initiation;Xenograft Model

PROJECT_TITLE: Cancer Biology & Evolution


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Autoimmune encephalitis is an increasingly recognized cause of neuroinflammatory diseases that present with a wide range of signs and symptoms ranging from ataxia to psychosis. This project leverages an innovative and high-throughput pipeline for identifying and regenerating autoantibodies from a cerebrospinal fluid biobank collected from a large and diverse cohort of patients with idiopathic encephalitis which will lead to improved diagnostics for autoimmune encephalitis, better understanding of its pathogenesis and insights into neural mechanisms that underly complex brain functions ranging from coordination to maintenance of mood and personality.

PI_NAMEs: DERISI, JOSEPH L.;PLEASURE, SAMUEL JEREMY;WILSON, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: MEINECKE, DOUGLAS L

PROJECT_TERMS: Affect;Amino Acids;Animal Disease Models;Animal Model;animal model development;Antibodies;Antibody titer measurement;Antigens;Ataxia;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmune encephalitis;Bacteriophages;biobank;Biological Assay;Biological Markers;Biological Products;Brain;Cell Separation;Cells;Cerebellum;Cerebrospinal Fluid;Classification;Clinical;clinically actionable;cohort;Collection;Communities;Complex;Cytoplasm;Dangerousness;Data;Databases;Defect;density;Development;Diagnostic;Disease;Encephalitis;Epitopes;Fc Receptor;Functional disorder;Goals;Human;Image;Immunosuppressive Agents;improved;In Vitro;in vivo;Inflammatory;Injections;innovation;insight;Knockout Mice;Libraries;Maintenance;Malignant Neoplasms;Memory;men;Mental disorders;Molecular;Monoclonal Antibodies;Moods;multiple sclerosis patient;Mus;N-Methyl-D-Aspartate Receptors;Natural regeneration;neural;neuroinflammation;Neurologist;neuromechanism;Neuropil;novel;Nuclear;Paraneoplastic Syndromes;Pathogenesis;pathogenic autoantibodies;Patients;Pattern;Peptides;Personality;Persons;Phage Display;Phage ImmunoPrecipitation Sequencing;Plasma Cells;Production;Protein Isoforms;Proteins;Proteome;Psychoses;Recombinants;Regional Anatomy;Sampling;Scientist;screening;Seizures;Seminoma;Signs and Symptoms;Specificity;Stains;Steroids;Structure;Synaptic Transmission;Syndrome;Testing;Tissue Stains;Tissues

PROJECT_TITLE: Autoimmune Encephalitis - Ataxia and Psychiatric Disease: Identifying and Characterizing Novel Antibody Targets


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Prevention;Prostate Cancer;Rare Diseases;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

PI_NAMEs: KANETSKY, PETER A (contact)

PROJECT_TERMS: Address;Affect;anti-cancer research;Area;Aspirin;Award;Biological;Biological Factors;Biological Markers;Biological Products;biomarker panel;black men;Brain;Breast;Breast Cancer Genetics;Breast Cancer Risk Factor;cancer biomarkers;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer epidemiology;Cancer Etiology;cancer health disparity;cancer prevention;cancer risk;cancer therapy;carcinogenesis;carcinogenicity;Catchment Area;Cervical;Chemoprevention;Clinical;Clinical Practice Guideline;Collaborations;Community Outreach;Constitution;Curcumin;Data;Development;Digital Mammography;Direct Costs;Disease;disorder risk;Early Diagnosis;Ensure;Environmental Risk Factor;epidemiology study;Equity;Exposure to;Faculty;Family;Fostering;Funding;Future;Gene Expression Profile;genetic information;Genetic Markers;Genetic Polymorphism;Genetic Predisposition to Disease;genetic testing;genome wide association study;genomic locus;Goals;Grant;Guidelines;Head and neck structure;Health Policy;Hematologic Neoplasms;Hematopoiesis;Heterogeneity;HIV;Human;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Image;Individual;individualized prevention;Indolent;Infectious Agent;Inherited;innovation;insight;International;Intervention;Intervention Trial;Investigation;Journals;Knowledge;Lead;Leadership;Learning;Lesion;lung lesion;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medicine;Melanoma;member;Methodology;Methods;molecular marker;Morbidity - disease rate;mortality;Mutation;Natural History;non-genetic;Normal tissue morphology;novel;Outcome;Pancreas;Participant;Pattern;Peer Review;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;Policies;Population;Population Research;Precancerous Conditions;prevent;Prevention strategy;Prevention trial;Primary Prevention;Principal Investigator;Process;Prognosis;programs;Prostate;Prostate Cancer Prevention Trial;Protective Agents;Protocols documentation;Public Health;Public Health Practice;Publications;Publishing;Race;Radiogenomics;Research;Research Activity;research clinical testing;research study;Risk;Role;Science;Secondary Prevention;tertiary prevention;Test Result;Testicular malignant germ cell tumor;Translating;translational impact;Translational Research;Translations;tumor;Update;Virus;Work

PROJECT_TITLE: Cancer Epidemiology


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROGRAM NARRATIVE Tumor metastasis to the liver is a leading cause of cancer death in the United States, and it is known to be associated with the increasing prevalence of obesity and non-alcoholic fatty liver disease. This Program represents the only coordinated, multi-investigator effort nationwide to focus on the causes of and approaches to address liver metastasis from cancers of the prostate, pancreas, and colon. Successful completion of the Program will lead to new targets for treatments for patients with liver metastasis.

PI_NAMEs: BHOWMICK, NEIL A.;LU, SHELLY CHI-LOO (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Acceleration;Address;Adopted;Animal Model;Bioinformatics;Biometry;cancer cell;Cancer Etiology;cancer type;Carcinoma;CD36 gene;Cessation of life;Clinical;Collaborations;Colon;Colon Carcinoma;Complement;Data;Dietary Intervention;Disparate;Doctor of Philosophy;Effectiveness;Endoglin;endoplasmic reticulum stress;Engraftment;Ensure;Environment;Epithelium;Extracellular Matrix;extracellular vesicles;falls;Fatty acid glycerol esters;Fatty Liver;Glutamate-Ammonia Ligase;Glutamine;glycogen synthase kinase 3 beta;Goals;Growth;Health Personnel;Healthcare Systems;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Histone Deacetylase;Home;Human;human tissue;Hyaluronic Acid;In Vitro;innovation;innovative technologies;Institution;Investigation;Kupffer Cells;Liver;liver development;Los Angeles;Macrophage;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Medical center;Metabolic;Metastatic Neoplasm to the Liver;methionine adenosyltransferase;MicroRNAs;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;non-alcoholic fatty liver disease;novel therapeutic intervention;Obesity;Oncogenic;Pancreas;Pathway interactions;Patients;permissiveness;pharmacologic;Phenotype;Prevalence;Primary Neoplasm;programs;Prostate;prostate cancer metastasis;Proteins;Publishing;recruit;Regulation;Research;Research Personnel;Resistance;Resources;Role;saturated fat;Signal Pathway;Signal Transduction;Signaling Protein;Specimen;success;System;Terminal Disease;Testing;Tissues;tool;tumor;Tumor Expansion;tumor growth;tumor microenvironment;Tumor Promotion;Tumor-Derived;United States;Work

PROJECT_TITLE: Determinants of Liver Metastasis


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Colorectal Cancer;Digestive Diseases;Liver Disease;Nutrition;Prostate Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE The liver is the most common site of metastasis of solid tumors after the lymph node, with no curative intervention. We found that intake of a high-fat diet, even for a relatively short period of time, is sufficient to increase the incidence of liver metastasis in mice. Our project examines whether inhibiting a central pathway elevated by high-fat diet in both cancer cells and liver hepatocytes will limit liver metastasis of colon, pancreas and prostate cancer. The findings could suggest therapeutic targets for the greater solid tumor patient population.

PI_NAMEs: BHOWMICK, NEIL A. (contact)

PROJECT_TERMS: Affect;Binding;Bioinformatics;Biometry;bone;Bone Morphogenetic Proteins;cancer cell;cancer type;Carcinoma;CD36 gene;Cell Surface Receptors;Cell Survival;Cells;Cessation of life;circulating cancer cell;Collaborations;colon cancer metastasis;Colon Carcinoma;curative treatments;Ecosystem;Endoglin;Energy-Generating Resources;ENG gene;Engraftment;Epithelial Cells;Epithelium;Exposure to;Fat-Restricted Diet;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Fatty Liver;feeding;FOXM1 gene;FRAP1 gene;Glutamate-Ammonia Ligase;Glutamine;Growth;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;Incidence;Intake;Ligands;Liver;lymph nodes;Malignant neoplasm of liver;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Liver;mortality;Mus;Nature;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neutralization Tests;notch protein;novel;Palmitates;paracrine;Pathway interactions;patient population;permissiveness;Play;Primary Neoplasm;Property;prostate cancer metastasis;receptor;Regulation;Resistance;Resources;response;Role;saturated fat;Saturated Fatty Acids;Signal Pathway;Signal Transduction;Signaling Protein;Site;Solid Neoplasm;stem;synergism;Testing;therapeutic target;Time;Transforming Growth Factor beta;tumor;Tumor Expansion;tumorigenesis;tumorigenic;uptake

PROJECT_TITLE: Project 1- Role of fat in metastatic engraftment and expansion in the liver


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: BRANDON, THOMAS H (contact)

PROJECT_TERMS: active method;addiction;Address;Adoption;Adult;Affect;Area;Automobile Driving;Awareness;Behavior;Behavioral;biobehavior;Black Populations;Black race;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Detection;cancer health disparity;cancer prevention;Cancer Survivorship;cancer therapy;care delivery;care providers;Caregivers;Caring;Catchment Area;Client;Clinical;clinical care;clinical practice;Collaborations;colorectal cancer screening;Communities;community barrier;community based participatory research;community engagement;community organizations;Congresses;County;Detection;Development;Diagnosis;Direct Costs;Distress;end of life;energy balance;evidence base;Evidence based intervention;Family;Federally Qualified Health Center;Food;former smoker;Fostering;Funding;Genetic Counseling;genetic testing;Goals;Grant;Guidelines;Health;Health behavior;Health behavior and outcomes;health care delivery;health disparity;health goals;Health Policy;Health Services Accessibility;Healthcare Systems;Hereditary Malignant Neoplasm;high risk population;Hispanic;Hispanic Populations;HIV;HPV vaccine acceptance;Human;implementation research;implementation science;improved;Individual;individualized prevention;innovation;Institution;International;Intervention;Intervention Studies;Laboratory Study;Long Term Survivorship;Long-Term Effects;low dose computed tomography;lung cancer screening;Malignant Neoplasms;member;novel strategies;Observational Study;Outcome;Patient Care;Patient Outcomes Assessments;Patients;Peer Review;Persons;Policies;population health;Population Heterogeneity;Populations at Risk;Practice Guidelines;Prevalence;Prevention;Process;programs;Provider;psychologic;psychosocial;Public Health;Publishing;Qualifying;Quality of life;quality of life for cancer survivors;Randomized, Controlled Trials;Recommendation;Reduce health disparities;reduce tobacco use;Research;Research Activity;Research Institute;Research Priority;Risk Factors;rural dwellers;screening;Screening for cancer;Services;side effect;Site;smoking cessation;Social Network;Survivors;survivorship;symptomatology;System;targeted treatment;therapy development;Tobacco use;Tobacco-Related Carcinoma;Translational Research;Translations;Underserved Population;United Nations;United States National Institutes of Health;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Health Outcomes & Behavior


NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Colorectal Cancer;Digestive Diseases;Liver Disease;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE The extent of liver metastasis is a major survival determinant for patients with colorectal and pancreatic cancer, as well as for those with prostate cancer, and non-alcoholic fatty liver disease is a serious health concerns that increase the risk of both primary cancers and liver metastasis. Project 2 will investigate the role of hepatic stellate cells, extracellular matrix hyaluronic acids, and hepatocyte-derived extracellular vesicles in supporting metastatic liver tumor growth in a fatty liver environment. Successful completion of Project 2 will provide new insight into the molecular mechanism underlying metastatic liver tumor growth in different liver conditions, which leads us to consider different therapeutic strategies for liver metastasis in patients with or without non- alcoholic fatty liver disease.

PI_NAMEs: SEKI, EKIHIRO  (contact)

PROJECT_TERMS: Acceleration;Animal Model;Biological Markers;Breast;cancer cell;Cancer Patient;cancer type;CD44 gene;Cell Proliferation;cell type;Cells;cohort;Collagen;Colon;Colorectal;Colorectal Cancer;Data;Defense Mechanisms;Elements;Endoglin;Engraftment;Environment;Enzymes;Extracellular Matrix;extracellular vesicles;Fatty Liver;feeding;Fibronectins;Growth;HAS2 gene;Health;Hepatic Stellate Cell;Hepatocyte;High Fat Diet;high risk;Human;Hyaluronic Acid;Incidence;Infiltration;innovation;insight;Invaded;Kupffer Cells;Liver;Liver Fibrosis;Liver neoplasms;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Liver;methionine adenosyltransferase;MicroRNAs;Molecular;mortality;mouse model;Myofibroblast;Neoplasm Metastasis;non-alcoholic fatty liver disease;novel;Obesity;Oncogenic;Organ;overexpression;Pancreas;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Patients;periostin;Plasma;Prevalence;Primary Neoplasm;Production;programs;Prostate;Proteins;receptor;Reporting;Research;Resources;Risk;Rodent Model;Role;scaffold;Signal Transduction;Site;Source;Specimen;Tenascin;Testing;Therapeutic;Tissues;Transgenic Mice;Travel;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Suppressor Proteins;Tumor-Derived;Visceral metastasis;Work

PROJECT_TITLE: Project 2 - Fatty Liver Predisposes to Metastasis: Role of Hepatic Stellate Cells


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The goal of this project is to define the diversity of the macrophage compartment of human lung tumors at the cellular and molecular level, and to determine the function of different macrophage subsets in tumor growth, remodeling, immunity, and response to immunotherapy. To achieve our objective, we will take advantage of unique immunotherapy trials in lung cancer, high-dimensional mapping techniques, including CITE-seq, and innovative culture systems and animal models of lung cancer.

PI_NAMEs: BROWN, BRIAN D;MERAD, MIRIAM  (contact)

PROGRAM_OFFICER_NAME: KUO, LILLIAN S

PROJECT_TERMS: adaptive immunity;Address;Adjuvant Study;Affect;analysis pipeline;Animal Model;anti-PD-1;Antibodies;Biology;Biopsy;cancer cell;cancer immunotherapy;cancer therapy;Cell Surface Receptors;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cellular Structures;Clinical;Country;Cytometry;Development;Epigenetic Process;epigenome;Excision;Genes;Genetic Transcription;Goals;Heterogeneity;high dimensionality;Homeostasis;Human;human tissue;Immune;Immunity;immunoregulation;Immunosuppression;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;Impairment;imprint;In Vitro;innovation;insight;Knock-out;Lesion;Lung;Lung Neoplasms;Macrophage;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Mediating;Molecular;monocyte;multiplexed imaging;Mus;Myelogenous;Natural Immunity;Neoadjuvant Therapy;Non-Small-Cell Lung Carcinoma;novel;Ontology;Operative Surgical Procedures;Organ;Outcome Study;participant enrollment;Pathway interactions;Patients;PD-1 blockade;PD-1/PD-L1;PD-L1 blockade;PDL1 pathway;Phenotype;Play;Population;Process;programmed cell death protein 1;programs;Proteomics;receptor;Resistance;Resolution;response;Role;Shapes;single cell analysis;single-cell RNA sequencing;Site;Spatial Distribution;Stimulus;Stromal Cells;Stromal Neoplasm;Surface;System;T-Lymphocyte;Techniques;Testing;therapeutic target;Tissues;transcriptomics;TREM2 gene;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Tissue

PROJECT_TITLE: Investigating Macrophage Molecular and Functional Diversity in Tumor Immunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases;Skin Cancer

PI_NAMEs: CONEJO-GARCIA, JOSE R (contact)

PROJECT_TERMS: Acceleration;Achievement;adaptive immunity;Adoptive Cell Transfers;Affect;anti-cancer;Area;B-Cell Lymphomas;Back;base;Beds;Biological;Biometry;Bone Marrow Transplantation;cancer cell;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;CAR T cell therapy;Catchment Area;Cell Therapy;Cells;Cellular immunotherapy;Cellular Metabolic Process;chimeric antigen receptor T cells;Clinical;Clinical Management;Clinical Services;Clinical Trials;Collaborations;Cutaneous Melanoma;Dedications;design;Development;Disease;Effectiveness;endoplasmic reticulum stress;Epigenetic Process;Funding;Goals;graft vs host disease;Grant;Guidelines;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;Immunity;Immunologics;Immunologist;Immunooncology;Immunotherapeutic agent;Immunotherapy;immunotherapy trials;improved;innovation;insight;Institution;Intervention;intervention refinement;Intervention Trial;Investments;Journals;Laboratory Study;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Manuscripts;Melanoma;member;Metabolic;Minority Groups;Molecular;Natural Immunity;Nature;novel;Oncology;oncology program;Outcome;Pathway interactions;Patients;Peer Review;personalized immunotherapy;Play;preclinical study;programs;Publications;Publishing;Refractory;Reporting;Research Activity;Research Personnel;Resistance;response;Role;Safety;Science;Solid;success;synergism;T-Lymphocyte;Testing;therapeutic effectiveness;Therapy trial;Toxic effect;translational medicine;Translational Research;treatment response;Treatment-related toxicity;tumor;Tumor Expansion;Tumor Immunity;Tumor-Infiltrating Lymphocytes;Underrepresented Minority;working group

PROJECT_TITLE: Immuno-Oncology


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Colorectal Cancer;Digestive Diseases;Liver Disease;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE We have designed a chemical entity that inhibits two key enzymes overactivated in pancreatic, colorectal, and prostate cancer cells, histone deacetylase (HDAC) and glycogen synthase kinase- 3β (GSK-3β), and preliminary results show that it has significant effects on cancer cell metastasis to the liver in animal models of pancreatic cancer. Based on these results and our knowledge of the interactions of cancer cells in the microenvironment of the primary cancer, we hypothesize that the two enzymes play a critical role in developing a microenvironment in the liver to promote cancer metastasis progression. The results of this project, in collaboration with others in the Program, will provide essential information to develop therapeutics for the prevention and treatment of metastases to the liver, a serious unmet medical need.

PI_NAMEs: PANDOL, STEPHEN J. (contact)

PROJECT_TERMS: Animal Model;cancer cell;cancer therapy;Cell Physiology;cell type;Chemicals;Collaborations;Colon Carcinoma;Colorectal Cancer;conditional knockout;Data;design;Disabling;Environment;Enzymes;Fatty Acids;Fatty Liver;glycogen synthase kinase 3 beta;Growth;HDAC3 gene;Hepatic;Hepatic Stellate Cell;High Fat Diet;Histone Deacetylase;Histone Deacetylase Inhibitor;Hyaluronic Acid;Immune;Immunologic Surveillance;insight;Interleukin-13;Interleukin-4;Knowledge;Kupffer Cells;Liver;Macrophage;macrophage stimulating protein;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;matriptase;Medical;metastasis prevention;Metastatic Neoplasm to the Liver;Modeling;Molecular Target;Mus;Neoplasm Metastasis;new chemical entity;novel;Outcome;pancreatic cancer model;Pathway interactions;Phenotype;Phosphotransferases;Play;polarized cell;Prevention;Process;programs;prostate cancer cell;Proteins;receptor;recruit;Regulation;Resistance;Role;Signal Pathway;Signal Transduction;Signaling Protein;small molecule;stellate cell;System;Therapeutic;Tissues;Transforming Growth Factor beta;translocase;tumor;Tumor Expansion;tumor growth;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: Project 3 - HDAC/GSK-3B/YAP signaling network in the liver metastatic microenvironment


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD) is a disorder that can cause progressive paralysis, dementia or a combination of these motor and cognitive symptoms. What determines whether or not a patient with ALS-FTD will have cognitive symptoms is currently poorly understood. This proposal uses novel genomics methods to understand what molecular pathways contribute to the development of cognitive impairment in ALS-FTD patients.

PI_NAMEs: PETRESCU, JOANA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Age;age stratification;Age Years;automated segmentation;Autopsy;Behavioral;Brain;career;Cell Physiology;cell type;Cells;Clinical;Cognitive;Cognitive deficits;cohort;Collaborations;Communication;Data;data modalities;Dementia;density;design;Development;Diagnosis;diagnostic criteria;differential expression;Discipline;Disease;Engineering;Environment;Exhibits;Fellowship;frontotemporal lobar dementia amyotrophic lateral sclerosis;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;Genomics;Genotype;Grant;human old age (65+);Image;imaging Segmentation;Impaired cognition;In Situ;insight;Manuscripts;Measures;Medical center;Mentorship;Methods;MFGE8 gene;Molecular;Morphology;Motor;Motor Manifestations;motor symptom;multimodality;multiplexed imaging;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;neuropathology;New York;non-demented;novel;Oral;Paralysed;Pathologic;Pathology;Pathway interactions;patient subsets;Patients;Persons;Phenotype;Physicians;pre-doctoral;Prefrontal Cortex;protein TDP-43;Proteins;Research;Sampling;Scheme;Science;Scientist;sex;skills;Spinal Cord;Staging;Stains;Sudden Death;Syndrome;Technology;Tissue Preservation;Tissues;Training;transcriptomics;Universities;Writing

PROJECT_TITLE: Clinicopathologic correlates of cognitive impairment in amyotrophic lateral sclerosis and frontotemporal dementia spectrum disorders (ALS-FTD)


NIH_SPENDING_CATS: Biotechnology;Cancer;Chronic Liver Disease and Cirrhosis;Colorectal Cancer;Digestive Diseases;Liver Disease;Rare Diseases

PHR: PROJECT NARRATIVE Methionine adenosyltransferase 1A (MAT1A) is expressed in normal liver and its expression falls in patients with fatty liver disease, whereas MAT2A and MAT2B are expressed in non-liver tissues and are induced in multiple human cancers. This project examines the hypothesis that while hepatic MAT1A protects the liver against cancer metastasis, elevated MAT2A and MAT2B expression in cancer cells lowers this defense. Successful completion of this project will reveal novel mechanistic insights that may help us to understand the complex interactions between the homing site (i.e., liver) and infiltrating cancer cells, which could lead to new therapies to prevent metastasis across all types of tumor.

PI_NAMEs: LU, SHELLY CHI-LOO (contact)

PROJECT_TERMS: Anabolism;Animal Model;BCL1 Oncogene;cancer cell;Cancer Cell Growth;Catalytic Domain;cell motility;Cell Proliferation;Cell Survival;cofactor;colon cancer metastasis;Colon Carcinoma;Complex;Data;Databases;Defense Mechanisms;Disseminated Malignant Neoplasm;Down-Regulation;Education;effective therapy;Endoglin;Enzymes;extracellular vesicles;falls;Fatty Liver;fatty liver disease;FOXM1 gene;Gene Expression;Genes;Growth;Hepatic;Hepatocyte;Homing;Human;Hyaluronic Acid;In Vitro;in vivo;Individual;Infiltration;inhibitor;insight;Invaded;Knock-out;Knockout Mice;Liver;Liver diseases;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Mammals;Measures;Mediating;MEKs;metabolome;Metastatic Neoplasm to the Liver;methionine adenosyltransferase;MicroRNAs;migration;Molecular;mouse model;Mus;Neoplasm Metastasis;non-alcoholic fatty liver disease;novel;novel marker;novel therapeutics;Oncogenes;Oncoproteins;overexpression;Pathway interactions;patient derived xenograft model;Patients;Plasma;Polyamines;Predisposition;prevent;Primary carcinoma of the liver cells;programs;Proteins;Ras/Raf;Regulation;Resources;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;scaffold;Serum;Signal Transduction;Site;Specimen;Steatohepatitis;synergism;Testing;Therapeutic;Tissues;transcription factor;Transgenic Mice;tumor;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: PROJECT 4: Targeting Methionine Adenosyltransferases in Liver Metastasis


NIH_SPENDING_CATS: Cancer;Precision Medicine

PI_NAMEs: DUCKETT, DEREK RONALD (contact)

PROJECT_TERMS: ABCB1 gene;Achievement;acquired drug resistance;Address;Advanced Development;analog;Area;Automobile Driving;Back;Basic Science;bench to bedside;Binding Proteins;Biochemical;Biological Assay;Biological Markers;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer therapy;Catchment Area;Cells;Chemicals;Chemistry;Clinic;Clinical;Clinical Trials;Collaborations;Community Outreach;Couples;Data;design;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Dose;drug discovery;Drug Kinetics;drug repurposing;Drug resistance;early phase clinical trial;Equilibrium;Equity;Fostering;Funding;Future;Genetic study;Genomics;Goals;Guidelines;Head and Neck Squamous Cell Carcinoma;Hematologic Neoplasms;Human;human cancer mouse model;Human Papillomavirus;improved;innovation;interdisciplinary approach;Intervention;investigator-initiated trial;Investments;Laboratories;Lead;Ligation;Machine Learning;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Medicine;Melanoma;member;metabolomics;Methods;Microsomes;Modeling;Molecular Medicine;Molecular Probes;Multi-Institutional Clinical Trial;multidisciplinary;Mus;National Comprehensive Cancer Network;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;older patient;Oncology;Oropharyngeal;participant enrollment;Pathway interactions;Patient Care;Patients;Peer Review;Periodicity;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phase;Phenotype;Physicians;Population;Populations at Risk;precision medicine;Precision therapeutics;predictive marker;Prognosis;programs;Property;Proteins;Proteomics;Publications;Publishing;recruit;Refractory;refractory cancer;Relapse;Research;Research Personnel;Resistance;Resolution;response;response biomarker;Role;safety assessment;Scientist;screening;Signal Pathway;Signal Transduction;Site;small molecule;Solid Neoplasm;Specimen;standard of care;Structural Biologist;Structure;Structure-Activity Relationship;success;synergism;System;Systems Biology;targeted agent;Technology;Testing;Therapeutic;Therapeutic Trials;tool;Translating;translational potential;Translational Research;tumor;tumor progression;tumorigenesis;United States Food and Drug Administration;working group

PROJECT_TITLE: Molecular Medicine


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Liver Disease

PHR: NARRATIVE A successful Program Project Grant (PPG) relies heavily on an outstanding scientific program that is supported by an equally outstanding Administrative Core (Core A). Core A will (1) provide scientific, administrative, fiscal, and organizational coordination of all the activities of the Projects and Cores, (2) facilitate interactions and data sharing, and (3) provide oversight and strategic planning and evaluation for the program as a whole. Core A is an essential component of the PPG to allow the PPG investigators to achieve their scientific goals.

PROJECT_TERMS: Award;Budgets;Collection;Committee Members;data sharing;Ensure;Evaluation;Expenditure;Goals;Leadership;meetings;member;Metastatic Neoplasm to the Liver;Monitor;Organizational Efficiency;Preparation;Program Evaluation;Program Research Project Grants;programs;Progress Reports;Protocols documentation;Publications;Reagent;Reporting;Research Personnel;Solid Neoplasm;Strategic Planning;Writing

PROJECT_TITLE: Core A: Administration


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: VADAPARAMPIL, SUSAN T (contact)

PROJECT_TERMS: Acceleration;access disparities;Address;Adoption;Awareness;Cancer Burden;cancer care;Cancer Center;Cancer Center Support Grant;cancer education;cancer health disparity;cancer prevention;cancer risk;CAR T cell therapy;Caring;Catchment Area;Characteristics;clinical care;Clinical Trials;Communities;community advisory board;community collaboration;community engagement;community organizations;Community Outreach;County;Cutaneous Melanoma;Data;Development;Diagnosis;Doctor of Philosophy;Early Diagnosis;Education;Education and Outreach;Equity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;Evidence based practice;Excess Mortality;experience;Faculty;Family;Florida;Foundations;Funding;Funding Mechanisms;Future;Genetic Risk;Geographic Locations;Grant;Health behavior;Health Services Accessibility;HIV;Human Papilloma Virus Vaccination;Incidence;innovation;Investments;Knowledge;Language;Leadership;Lung;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;malignant oropharynx neoplasm;Medicare;member;Mission;Modality;Monitor;neoplasm registry;novel;Organizational Culture;outreach;Patients;Persons;Policies;Population;preference;Prevention;preventive intervention;programs;Race;Research;Research Personnel;research study;Research Support;response;Risk Factors;Risk Reduction Behavior;Role;Science;screening;Screening for cancer;screening program;Skin Cancer;sociodemographics;Spanish;statistics;Structure;Surveys;Tobacco;Tobacco-Related Carcinoma;Trust;Underserved Population;United States;uptake;UV Radiation Exposure;Vaccines;Vulnerable Populations;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Liver Disease;Nanotechnology;Pancreatic Cancer;Rare Diseases;Urologic Diseases

PHR: PROJECT NARRATIVE Tumor metastasis to the liver is a leading cause of cancer death in the United States. This Program represents the only coordinated, multi-investigator effort nationwide to focus on the causes of and approaches to address liver metastasis. Core B will supply human tissues and animal models to support the four Program Projects in studying interactions between the liver microenvironment and the metastatic tumor cells that colonize it.

PI_NAMEs: POSADAS, EDWIN MELENCIO (contact)

PROJECT_TERMS: Address;analytical tool;Animal Model;Autopsy;Basic Science;Biological;Biological Assay;Biological Markers;Biomedical Research;Biostatistics Core;Blood;Blood specimen;blood-based biomarker;Cancer Etiology;Cessation of life;Clinic;Clinical;Clinical Sciences;Collection;Colonic Neoplasms;Complement;Cost efficiency;data communication;data sharing;Defense Mechanisms;Development;Disparate;Engraftment;experience;extracellular vesicles;FDA approved;Generations;Goals;Growth;Health Personnel;Healthcare Systems;Human;human tissue;in vivo Model;innovative technologies;insight;Institutional Review Boards;Investigation;Liver;liver development;Los Angeles;Malignant Neoplasms;Medical center;Metastatic Neoplasm to the Liver;Methods;model development;Modeling;mouse model;Mus;nano-string;nanotechnology platform;NanoVelcro;Natural History;Nebraska;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new technology;novel;operation;Output;pancreatic cancer model;pancreatic neoplasm;Pathologic;patient derived xenograft model;Patients;Persons;pharmacologic;Physiological;Procedures;Process;Productivity;Program Efficiency;programs;Prostatic Neoplasms;Protocols documentation;Research;Research Personnel;Resources;Sampling;Services;Signal Transduction;Site;Specimen;Standardization;synergism;Tissue Banks;Tissue Model;Tissues;tool;Transgenic Organisms;Translating;tumor;Tumor Tissue;United States;Universities;Variant;Work

PROJECT_TITLE: Core B: Liver Metastasis Resource Core (LMRC)


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Liver Disease;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE The Biostatistics and Bioinformatics Core serves as a comprehensive, multi-disciplinary resource of expertise in biostatistics and bioinformatics to assist investigators from all projects to design their experiments, manage and maintain the large volume of data, make inference regarding the stated aims, and formulate new hypotheses based on discoveries arising from exploration and visualization of the integrated data.

PI_NAMEs: TIGHIOUART, MOURAD  (contact)

PROJECT_TERMS: Achievement;Address;analysis pipeline;Animal Experiments;anti-cancer research;Basic Science;Bioinformatics;Biometry;Collaborations;Computer software;Computers;Computing Methodologies;Data;data access;Data Analyses;data integration;data management;Data Storage and Retrieval;Database Management Systems;Databases;design;Development;Ensure;experimental analysis;Experimental Designs;experimental study;Foundations;Goals;Health Insurance Portability and Accountability Act;high dimensionality;innovation;Institutional Review Boards;Investigation;laboratory experiment;Manuscripts;mathematical model;member;Metastatic Neoplasm to the Liver;Methodology;multidisciplinary;Nature;Outcome;Participant;Patients;preservation;Procedures;Program Research Project Grants;programs;Randomized;Regulation;relational database;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;research study;Research Support;Resources;Retrieval;Role;Sample Size;Source;Specimen;Statistical Data Interpretation;statistics;Structure;Techniques;Testing;tool;Translating;Translational Research;Variant;Visualization;Writing

PROJECT_TITLE: Core C: Biostatistics Bioinformatics Core


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: BIOLOGY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative This MIRA proposal seeks to understand molecular, cellular, and circuit mechanisms of nociception in a genetically tractable model organism.

PI_NAMEs: TRACEY, WILLIAM D (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Afferent Neurons;Animals;Behavior;Dedications;forward genetics;gene conservation;Gene Expression Profile;Genes;Goals;Knowledge;Laboratories;Modality;model organism;Molecular;Morphology;Neurons;Nociception;Nociceptors;Pathway interactions;Play;programs;Proprioception;Research;Role;Sensory;sensory mechanism;Signal Transduction;Stimulus;Tissues;Touch sensation

PROJECT_TITLE: Molecular, Cellular, and Circuit Mechanisms of Nociception Behavior

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Prevention;Racial and Ethnic Minority Health Research

PI_NAMEs: SOLIMAN, HATEM  (contact)

PROJECT_TERMS: Accountability;Address;Adherence;Adult;Adverse event;African American;Age;Biological Markers;black patient;Black race;Cancer Center;Cancer Center Support Grant;Catchment Area;Clinic;Clinical;Clinical Data;Clinical Management;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Communication;community research;Conduct Clinical Trials;Consent;Data;data management;Data Management Resources;data quality;design;Development;Development Plans;Diagnostic;Education;education research;Educational Curriculum;Educational Personnel;Educational workshop;Eligibility Determination;Ensure;Event;Faculty;Goals;high standard;Hispanic;human old age (65+);improved;Individual;Informed Consent;innovation;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;Knowledge;Latinx;Life Cycle Stages;life span;Malignant Neoplasms;member;Minority;minority communities;Monitor;outreach;Outreach Research;outreach services;Patient Care;Patients;Performance;Persons;Pharmaceutical Preparations;Physicians;Policies;Population;Positioning Attribute;Prevention strategy;Procedures;programs;protocol development;Protocols documentation;quality assurance;Reporting;Research;Research Personnel;research study;Safety;Safety Management;Services;Site;Special Population;Structure;Supportive care;Talents;Testing;Time;Training;Training and Education;Translating;treatment trial;Underserved Population;Update;Woman;Work;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Genetics

ORG_CITY: CHESTNUT HILL

ORG_NAME: BOSTON COLLEGE

PHR: Project Narrative Polyploidy is the more than doubling a cell’s diploid genome and arises in response to injury, aging, and disease. Cells exhibit distinct ploidy states (mononucleated or multinucleated), however it remains poorly understood how a cell’s ploidy state affects its physiology. Therefore, the goal of this proposal is to elucidate how ploidy state alters resistance to genotoxic stress and cytoskeletal mechanics, two physiological roles for polyploidy in health and disease.

PI_NAMEs: LOSICK, VICKI P (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Actomyosin;Adult;Affect;Aging;cell growth;Cell Nucleus;Cells;Chromosomes;Cytoskeleton;Diploid Cells;Disease;Disease susceptibility;Drosophila genus;Drosophila melanogaster;Epithelial Cells;epithelial wound;Epithelium;Exhibits;Genetic;Genome;Genotoxic Stress;Goals;Growth;Health;Heterogeneity;Human;insight;Laboratories;Mechanics;Modeling;Movement;novel;Organ;Physiological;Physiology;Ploidies;Polyploid Cells;Polyploidy;Prevalence;Regulation;repaired;Resistance;response to injury;Role;Stress;Tissues;UV induced DNA damage;Vertebrates;wound healing

PROJECT_TITLE: The Regulation of Polyploidy in Health and Disease


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Skin Cancer

PI_NAMEs: CLEVELAND, JOHN L. (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Animal Cancer Model;Area;Award;Calendar;cancer care;Cancer Center;Cancer Center Support Grant;cancer diagnosis;care delivery;Caring;Catchment Area;Categories;Cervix Uteri;Clinic;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;Complex;Cutaneous Melanoma;Data Science;Dedications;Department chair;Development;Doctor of Philosophy;Equipment;Evaluation;Extramural Activities;Faculty;Faculty Recruitment;Fostering;Funding;Funding Opportunities;Gene Targeting;Goals;Grant;Growth;health disparity;Human Papilloma Virus Vaccination;Human Papilloma Virus-Related Malignant Neoplasm;Immunization;Immunooncology;implementation science;Infection;Infrastructure;innovation;Institution;interdisciplinary collaboration;interest;investigator-initiated trial;Investments;Laboratories;Leadership;Lung;lung cancer screening;Malignant neoplasm of cervix uteri;Malignant neoplasm of lung;Malignant Neoplasms;meetings;Melanoma;member;Mentors;Metabolism;Minority Groups;Mission;Monitor;Oropharyngeal;Ovary;participant enrollment;Peer Review;Physicians;Pilot Projects;Play;Population;Prevention;programs;Progress Reports;Publications;Reporting;Research;Research Activity;Research Personnel;Research Support;Resource Development;Resource Sharing;Resources;Risk Factors;Role;Science;Scientific Advances and Accomplishments;Series;Services;Skin;Skin Cancer;Strategic Planning;Strategic vision;Time;Tobacco use;Translating;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;UV Radiation Exposure;Work;working group

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: PHARMACOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative Previous work suggested that normal hematopoietic progenitor cells undergo transient de- condensation of nascent chromatin in order to allow lineage-specific transcription factors to bind to their gene targets and to activate new transcriptional programs, leading to cell differentiation. Lymphoid B-ALL and TCLL leukemic cells lost this ability to de-condense nascent chromatin, which may explain their inability to differentiate and their increased proliferative capability. We propose to overcome these barriers of reprogramming-based therapies of lymphoid leukemic cells through de-condensing their nascent chromatin and by inducing transcriptional reprogramming, which will lead to reduced proliferation, differentiation, and cell death.

PI_NAMEs: CALABRETTA, BRUNO  (contact);MAZO, ALEXANDER M

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute leukemia;Acute Promyelocytic Leukemia;Affect;Apoptosis;Arsenic Trioxide;B-Cell Leukemia;B-Lymphocytes;Binding;Biological;Blast Cell;Cancer Biology;cancer cell;cancer therapy;Cell Aging;Cell Cycle Inhibition;Cell Death;Cell Differentiation process;Cell Line;Cell Maturation;Cell Reprogramming;Cell Survival;Cells;Chromatin;Chromatin Structure;clinical application;cytokine;Data;Differentiation Therapy;DNA;DNA Binding;DNA biosynthesis;Epigenetic Process;Exhibits;experience;EZH2 gene;Failure;Foundations;gene repression;Gene Targeting;Genes;Genetic Transcription;Genome;genome-wide;Goals;hematopoietic stem cell differentiation;Hematopoietic stem cells;Heterogeneity;histone methyltransferase;Immunodeficient Mouse;Immunophenotyping;in vivo;Induction of Apoptosis;inhibitor;Knowledge;Laboratories;leukemia;leukemia/lymphoma;Leukemic Cell;Ligand Binding;Ligands;Lymphoblastic Leukemia;Lymphoid;Lymphoma cell;Molecular;mouse model;Mus;Mutate;Mutation;Nature;neoplastic cell;novel;novel strategies;Nucleic Acid Regulatory Sequences;Nucleosomes;Outcome;Patient-Focused Outcomes;Patients;pharmacologic;Physical condensation;Process;programs;Proliferating;Publishing;receptor;Repression;Role;Sampling;self-renewal;small molecule;Solid;Specific qualifier value;stem cells;Structure;T cell differentiation;T-Cell Leukemia;Testing;Therapeutic Agents;transcription factor;transcriptional reprogramming;treatment strategy;Tretinoin;Work;Xenograft procedure

PROJECT_TITLE: A novel strategy for transcriptional reprogramming of lymphoid leukemia cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-H(02)M]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PROJECT_TERMS: Acceleration;Address;Advisory Committees;anti-cancer research;Area;Award;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Science;care delivery;Catchment Area;Clinical;Clinical Research;Collaborations;Committee Members;Committee Membership;Communities;community advisory board;Community Outreach;Consult;COVID-19 pandemic;Data Science;Department chair;Development;Education;Ensure;Evaluation;Faculty;Family;Fostering;Funding;Goals;Grant;Grant Review;Growth;health disparity;Immunooncology;Impact evaluation;implementation science;Infrastructure;innovation;interdisciplinary collaboration;International;Journals;Leadership;Malignant Neoplasms;meetings;member;Mentors;Metabolism;Minority;Mission;Monitor;new technology;Patients;Peer Review;pharmacokinetics and pharmacodynamics;Policies;Prevention;Process;programs;Public Health Practice;Publications;Recommendation;recruit;Research;Research Activity;research faculty;Research Priority;Research Support;Resource Sharing;Resources;Review Committee;Science;Site;Strategic Planning;Structure;success;Talents;Technology;Therapeutic Clinical Trial;Therapeutic Intervention;Tissues;Training Activity;Training and Education

PROJECT_TITLE: Leadership, Planning and Evaluation


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Through our efforts nearly 30 years, we have established a new PD genetic locus on chromosome 20, identified TMEM230 as a new PD-linked gene, developed a series of TMEM230 mouse models, and found that synaptic vesicle recycling deficit may underlie the pathogenesis of TMEM230-linked PD. This project is designed to test the role of TMEM230 in synaptic vesicle recycling, and to determine the molecular mechanism in TMEM230-linked PD. Understanding the molecular mechanism may provide a pathophysiological basis for PD therapeutic development.

PI_NAMEs: DENG, HAN-XIANG  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: 2 year old;20p;Adaptor Protein Complex 2;Address;Affect;Age Months;American;Auxilins;Binding;Binding Proteins;Biochemical;Biogenesis;Chromosome 20;Clathrin;Clinical;CRISPR/Cas technology;Data;Defect;design;Development;Disease;DNA;Dopamine;Endocytosis;Endosomes;Exocytosis;exome sequencing;Exploratory/Developmental Grant;Family;Functional disorder;Functional impairment;Funding;Genes;Genetic;genomic locus;Goals;Human;Impairment;Individual;Integral Membrane Protein;Knock-in Mouse;Knockout Mice;LacZ Genes;Link;LRRK2 gene;Maps;Measures;Mediating;member;Missense Mutation;Modeling;Modification;Molecular;motor deficit;mouse model;Mus;Mutation;N-terminal;National Institute of Neurological Disorders and Stroke;Neurons;neurophysiology;neurotransmission;nigrostriatal pathway;Outcome Study;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Periodicity;Phenotype;Physiological;Play;presynaptic;Process;Property;Protein Isoforms;protein transport;Proteins;Recycling;Resources;Retrieval;Role;Sampling;Scanning;screening;secretory protein;Series;Site;Sorting;sporadic Parkinson's Disease;Stimulus;Study models;Synaptic Membranes;Synaptic Transmission;Synaptic Vesicles;SYNJ1 gene;Testing;therapeutic development;Time;trafficking;Transgenic Mice;United States National Institutes of Health;Vesicle;Work

PROJECT_TITLE: Mouse model studies of TMEM230-linked Parkinson's disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: KHUSHALANI, NIKHIL  (contact)

PROJECT_TERMS: Advisory Committees;Algorithms;Amendment;anti-cancer research;Area;authority;Award;Cancer Center;Cancer Center Support Grant;Caring;Catchment Area;Clinical;clinical center;clinical implementation;Clinical Investigator;Clinical Research;Clinical Research Protocols;Clinical Sciences;clinical trial protocol;Clinical Trials;Data;Databases;design;Disease;disease diagnosis;Documentation;Ensure;experience;Goals;human subject;Immunotherapy;Infrastructure;Institution;Intervention Studies;Knowledge;Malignant Neoplasms;Medical;member;Minority Groups;Modeling;Monitor;Oncology;patient population;Patients;Phase;Policies;Population;Procedures;Process;Protocols documentation;Qualifying;rare cancer;Research;research study;response;Review Committee;Role;Safety;Scientist;Source;standard of care;Support System;System;Time;Tissues;Vulnerable Populations;working group

PROJECT_TITLE: Protocol Review and Monitoring System


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Data Science;Diabetes;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: NARRATIVE Health disparities by race/ethnicity exist in the prevalence and outcomes of cataract, glaucoma, and diabetic retinopathy, but the impact of social determinants of health on quality metrics for care of these conditions is poorly understood. The Health Disparities in Utilization, Quality, and Outcomes for Three Common Ocular Conditions (HealthDOC) study seeks to understand the association of the social determinants on National Quality Forum and clinically meaningful measures, and mortality for racial and ethnic minority patients using an innovative strategy that incorporates data from the Sight OUtcomes Research CollaborativE (SOURCE). This research will have high impact by providing the health sector and other stakeholders with essential information about the quality of ocular care, which is needed for informed interventions aimed at reducing health disparities and improving quality.

PI_NAMEs: FRENCH, DUSTIN D. (contact);STEIN, JOSHUA D

PROGRAM_OFFICER_NAME: LE, JIMMY TOAN

PROJECT_TERMS: Academy;Accident and Emergency department;Achievement;Advisory Committees;Affect;Affordable Care Act;American;Area;Attention;Authorization documentation;Big Data;Biological;Blindness;Caring;Cataract;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Chronic Disease;Clinical;Clinical Data;Clinical Trials;Communities;Data;data platform;data resource;Data Sources;deprivation;Development;diabetic;Diabetic Retinopathy;Disease;Disparity;Distress;Economically Deprived Population;Educational Status;electronic health data;Electronic Health Record;Ethics;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Eye;Eye diseases;Future;Gender;Glaucoma;Glycosylated hemoglobin A;Goals;Health;health care disparity;health data;health disparity;health management;Health Services;Health Services Accessibility;Health Services Research;Healthcare;Healthcare Systems;Healthy People 2020;hospital readmission;improved;Incentives;indexing;Inferior;innovation;insight;Insurance Coverage;Intervention;Life Expectancy;Link;Measures;Medical;Medicare;Medicine;Michigan;Minority;Minority Groups;minority patient;Mission;Morbidity - disease rate;mortality;mortality risk;National Eye Institute;Ophthalmologist;Ophthalmology;Outcome;Outcomes Research;Patients;payment;Peer Review;Persons;Pharmaceutical Preparations;Play;Policies;Prevalence;Prevention;programs;Quality of Care;Race;racial health disparity;racial minority;racial minority population;racial population;Reduce health disparities;repository;Research;Research Design;Research Personnel;residence;Retinal Diseases;Risk Adjustment;Role;Severity of illness;Site;social determinants;social health determinants;System;tertiary care;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;Vision;Visual;Visual impairment;Work

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: O'CONNELL, CHRISTINE  (contact)

PROJECT_TERMS: Adopted;Advisory Committees;animal imaging;anti-cancer research;Basic Science;Bioinformatics Shared Resource;Biology;Biometry;Cancer Center;Cancer Center Support Grant;Capital;Career Ladders;CCL21 gene;Cell Therapy;Chemicals;Clinical;Clinical Sciences;Clinical Trials;Committee Members;Communities;cost;cost effective;Data;Decision Making;Dedications;Development;Drug Kinetics;Education;Ensure;Equipment;Evaluation;expectation;Faculty;Faculty Recruitment;faculty support;Flow Cytometry;Fostering;Funding;Future;Gene Targeting;Genomics;Goals;Hand;Health;Human Resources;Individual;innovation;instrumentation;Intervention;Intervention Trial;Investments;Journals;Laboratories;Leadership;Location;Management Information Systems;Measurement;member;metabolomics;Microscopy;Modeling;Molecular;new technology;notch protein;operation;Participant;Peer Review;Peer Review Grants;Performance;Pharmacodynamics;Policies;Population;Procedures;Process;programs;Proteomics;Publications;quantitative imaging;Reproducibility;Research;Research Support;Resource Sharing;Resources;Sampling;Science;Services;Standardization;Strategic Planning;Structure;Surveys;Technology;Tissues;Training;Training and Education;Update

PROJECT_TITLE: Shared Resource Management


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Physical Injury - Accidents and Adverse Effects;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Violence Research

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Sexual minority men (SMM) experience intimate partner violence (IPV) at alarming rates and prior work has linked IPV with sexual risk-taking behavior and increased risk for HIV seroconversion among SMM, but less is known about the impact of IPV on HIV testing, pre-exposure prophylaxis (PrEP) uptake, and the persistence of PrEP use among SMM. The proposed innovative observational cohort study will examine how perpetration and/or receipt of various forms of IPV (e.g., physical, sexual, and psychological; in the context of steady or casual intimate relationships) contribute to HIV risk and protective behaviors among HIV-negative SMM over a 24-month timeframe. This research will advance our understanding of both the risk and resiliency factors relevant to preventing and reducing IPV, reducing HIV risk behaviors, and increasing HIV protective behaviors among SMM.

PI_NAMEs: STORHOLM, ERIK D. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: Address;Adult;AIDS prevention;Alcohol consumption;Behavior;Buffers;Characteristics;Child Abuse;Chronic;cis-male;cohort;condomless anal sex;Coping Skills;Cross-Sectional Studies;Data;design;Development;Diagnosis;effective intervention;Emotional;Etiology;experience;follow-up;Frequencies;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;inattention;Individual;innovation;internalized stigma;Interruption;Intervention;intimate partner violence;Knowledge;Life Experience;Link;Los Angeles;Measures;Mediating;Mental Health;Methodology;Methods;minority stress;minority stressor;observational cohort study;Outcome;Participant;Pathway interactions;pre-exposure prophylaxis;Prevalence;prevent;primary outcome;prospective;protective behavior;psychologic;psychological violence;Psychosocial Factor;Recommendation;Recording of previous events;recruit;Research;Research Activity;resilience;resilience factor;Risk;Risk Behaviors;Risk Factors;risk mitigation;secondary outcome;self esteem;Severities;sexual minority;sexual minority men;Sexual Partners;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Shapes;social;Social support;Stress;structural determinants;Substance abuse problem;substance use;syndemic;Testing;theories;Time;uptake;Victimization;Violence;violence perpetration;violence prevention;Woman;Work

PROJECT_TITLE: Intimate Partner Violence and HIV Prevention among Sexual Minority Men

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

ORG_STATE: TX

PHR: Project Narrative The advanced prostate cancer (CaP) is initially amenable for androgen deprivation therapy (ADT), and eventually, there is an emergence of CRPC. Next-generation ADT agents (abiraterone and enzalutamide) and chemotherapy are not curative of CRPC. Hence, the overall goal of the proposal is to determine the mechanism by which our small molecules (ASR-600 & ASR-603) target androgen receptor (AR) and androgen receptor splice -variants (AR-SV) in castration-resistant prostate cancer.

PI_NAMEs: DAMODARAN, CHENDIL  (contact);SHARMA, ARUN K

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acute;advanced prostate cancer;analog;androgen deprivation therapy;androgen independent prostate cancer;Androgen Receptor;Androgens;Binding;Binding Sites;Biological Assay;Biological Availability;biophysical analysis;Body Weight;Calorimetry;Cancer Patient;Cell Death;Chemicals;chemotherapy;Cytosol;design;Development;Dose;dynamic system;efficacy evaluation;enzalutamide;Foundations;Goals;Growth;Histopathology;implantation;In Vitro;in vivo;in vivo Model;inhibitor;Label;Maximum Tolerated Dose;Mediating;meter;Modeling;Molecular;molecular dynamics;Mus;N-terminal;next generation;novel lead compound;Nuclear Magnetic Resonance;Oral;Oral Administration;Outcome;patient derived xenograft model;Pattern;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Physiological;Pre-Clinical Model;pro-apoptotic protein;Property;prostate cancer cell;prostate cancer cell line;prostate cancer progression;protein expression;rational design;Receptor Activation;receptor expression;Receptor Signaling;Research;Resistance;RNA Splicing;Series;Signal Transduction;simulation;Site;small molecule;Solubility;Stanolone;Stimulus;Structure-Activity Relationship;Tertiary Protein Structure;Testing;Therapeutic;Titrations;Toxic effect;Treatment Efficacy;tumor growth;Tumor Tissue;Ubiquitination;Urology;Variant;Xenograft procedure

PROJECT_TITLE: Targeting AR and AR-Variants in Castration-Resistant Prostate Cancer

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]