NIH_SPENDING_CATS: Bioengineering;Cancer

PI_NAMEs: SEMERAD, CRAIG  (contact)

PROJECT_TERMS: analog;Area;assay development;Automation;base;Biological;Biological Assay;Cancer Center;Cancer Center Support Grant;Cell Cycle;Cell Separation;cell separator;Cells;Client;Color;Communities;Competence;cost;Data;design;Development;DNA;DNA biosynthesis;Education;Ensure;Evaluation;Experimental Designs;Fee-for-Service Plans;Flow Cytometry;Flow Cytometry Shared Resource;Goals;Immunophenotyping;instrument;instrumentation;Knowledge;Laboratories;Lasers;magnetic cell separation;Magnetism;Measurement;Modeling;Preparation;protein expression;Protein Secretion;Protein Sortings;Protocols documentation;Research;research facility;Research Personnel;Resolution;Resource Sharing;Resources;Safety;Sampling;Services;Solid;Sorting;System;Technical Expertise;Technology;Training;Training and Education

PROJECT_TITLE: Flow Cytometry Shared Resource


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PI_NAMEs: BROWN, ARLEEN F. (contact)

PROJECT_TERMS: Address;Advocacy;Affect;Behavioral trial;Chronic;Clinical;Clinical Trials;Collaborations;Communities;community based participatory approach;community engaged research;community engagement;community organizations;Consultations;Development;Diabetes Mellitus;Disparity;Enrollment;Equity;ethnic minority;Evidence based practice;Exclusion;experience;Face;Feasibility Studies;Foundations;Geographic Locations;Goals;Health;health equity;Health equity research;high risk;Immigrant;improved;Individual;innovation;Intervention;Knowledge;Lived experience;Low income;marginalization;member;Modeling;Monitor;Morbidity - disease rate;mortality;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;operation;Patients;Phase;Policies;Population;Prevention approach;preventive intervention;Process;programs;racial diversity;racial minority;real world application;Recommendation;Recording of previous events;recruit;Research;Research Design;Research Personnel;Resources;retention rate;Risk Factors;Risk Reduction;Services;Sexual and Gender Minorities;social;social determinants;social health determinants;structural determinants;Structure;System;Training;Translations;Vision

PROJECT_TITLE: Stakeholder Engagement Studio Core


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: EUDY, JAMES  (contact)

PROJECT_TERMS: assay development;Biological;Biological Assay;Budgets;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cells;cellular imaging;Chemicals;Communication;Communities;Computer software;Consultations;cost;Data;design;Dideoxy Chain Termination DNA Sequencing;DNA sequencing;Educational workshop;Effectiveness;Equipment;exome;Experimental Designs;Faculty;functional genomics;Gene Expression Profiling;Genes;genome sequencing;genome-wide;Genomics;graduate student;high throughput screening;Human Resources;Image;Infrastructure;instrumentation;Laboratories;Lead;Learning;lectures;Malignant neoplasm of gastrointestinal tract;meetings;member;Mentors;Metagenomics;Methods;miRNA expression profiling;Mission;Molecular;Molecular Biology;Molecular Biology Shared Resource;mRNA sequencing;nano-string;next generation;next generation sequencing;operation;Organism;Performance;Population;Postdoctoral Fellow;Procedures;Process;programs;Reagent;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Ribosomes;RNA;screening;Services;single cell genomics;skills training;Small Interfering RNA;small molecule;Students;symposium;targeted sequencing;Techniques;Technology;Tissues;Training;transcriptome sequencing;Update;Validation;virtual;whole genome

PROJECT_TITLE: Molecular Biology Shared Resource

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE To understand function of every human gene, the Molecular Phenotypes of Null Alleles in Cells (MorPhiC) program is experimentally deleting each gene in tissue culture cells and then applying cutting-edge molecular tools to determine how the deletion affects the cells' behavior. Because transcription factors regulate the genes that control cell behaviors, our goal is to ensure that the effects of transcription factor deletion on the cells are accurately and consistently quantified so that this information can ultimately be used by the biomedical community to improve healthcare. Thus, we propose to establish a MorPhiC Data Analysis and Validation Center to 1) computationally analyze the quality of multiple types of genomic data collected from these cells and 2) determine whether these data can be used to accurately identify the network of genes regulated by a specific transcription factor.

PI_NAMEs: WHITE, BRIAN S (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Affect;Alleles;ATAC-seq;Auxins;Biological;Biological Assay;biological heterogeneity;Biological Models;Biomedical Research;Catalogs;cell behavior;Cell model;cell type;Cells;Characteristics;ChIP-seq;Chromatin;Collaborations;Collecting Cell;Communities;Computing Methodologies;CRISPR/Cas technology;crowdsourcing;Data;Data Analyses;data mining;Databases;differential expression;diverse data;Drops;dynamic system;Ensure;Epigenetic Process;experimental study;Gene Expression Regulation;gene function;gene network;gene regulatory network;Gene Targeting;Genes;Genetic Transcription;genomic data;Genomic medicine;genomic variation;Goals;Healthcare;heterogenous data;Human;Human Genome;improved;in silico;Individual;knock-down;knockout gene;Knockout Mice;Knowledge;Messenger RNA;Methods;Molecular;molecular phenotype;Molecular Profiling;Molecular Target;multimodal data;multiple omics;National Human Genome Research Institute;Noise;novel;novel strategies;Outcome;Participant;Penetrance;Performance;Phase;Phenotype;phenotypic data;Positioning Attribute;power analysis;Production;programs;Proteins;Protocols documentation;Publishing;Recommendation;Regulation;Regulon;Reporter;Role;single cell sequencing;single-cell RNA sequencing;Source;success;System;The Jackson Laboratory;Time;tissue/cell culture;Tissues;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Validation;Vision;Work;XCL1 gene

PROJECT_TITLE: Multi-omic phenotyping of human transcriptional regulators


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: FOSTER, KIRK W (contact)

PROJECT_TERMS: Abdomen;Academic Medical Centers;Antibodies;Antigens;Automation;Autopsy;Basic Science;Benign;biobank;Biological Assay;Blood;Cancer Center;Cancer Center Support Grant;Cell Culture Techniques;Cell Survival;Chest;Client;Collaborations;Consultations;Core Facility;cost effective;Custom;Database Management Systems;design;Detection;digital imaging;digital pathology;Directories;Disease;DNA;Education;Educational workshop;Effectiveness;Enzymes;Equipment;equipment training;Faculty;Fishes;Formalin;Fostering;Freezing;Frozen Sections;Genes;Hematologic Neoplasms;Histology;human biological material;Human Resources;human tissue;Image;Image Analysis;Immunohistochemistry;improved;In Situ Hybridization;Individual;innovation;Institutional Review Boards;instrumentation;interdisciplinary collaboration;Interdisciplinary Study;Laboratories;laboratory experience;Laboratory Scientists;Liquid substance;Malignant - descriptor;Malignant neoplasm of pancreas;Management Information Systems;Measures;member;Mentors;Messenger RNA;Methodology;Modernization;Morphology;Neoplasm Metastasis;neoplastic;Neoplastic Processes;Nitrogen;novel;Occupations;Online Systems;Organ;Organ Harvestings;Organoids;Pancreas;Paraffin;Paraffin Embedding;Paraffin Tissue;Pathologic;Pathology;Pathology processes;Patients;preservation;Primary Neoplasm;Process;process improvement;Prospective Studies;Proteins;Protocols documentation;quality assurance;Quality Control;Registries;Reproducibility;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Retrospective Studies;Review Committee;RNA;Sampling;Science;Services;Slide;Stains;Standardization;Suspensions;Testing;Tissue Banks;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Procurements;tissue resource;Tissue Sample;Tissues;tool;Training;Translational Research;Urine;Viscera;whole slide imaging

PROJECT_TITLE: Pathology Shared Resource


NIH_SPENDING_CATS: Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: CHAMBERS, EARLE C (contact)

PROJECT_TERMS: Address;Collaborations;Communities;community engagement;community partners;Complement;Complex;Consultations;design;Diabetes Mellitus;Discipline;Disparity;dissemination science;dynamic system;Equity;Ethics;Faculty;Fostering;Funding;Goals;Health;health equity;health inequalities;Health system;Healthcare Systems;Immigrant;implementation science;Information Dissemination;Infrastructure;innovation;Institution;intersectionality;Intervention;Leadership;Legal;Life Cycle Stages;member;Methodology;Methods;Modeling;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute on Minority Health and Health Disparities;next generation;Non-Insulin-Dependent Diabetes Mellitus;operation;Persons;population health;Population Heterogeneity;pragmatic trial;programs;Qualitative Methods;Recommendation;Research;Research Design;Research Ethics;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;research study;Resources;service delivery;Services;Sexual and Gender Minorities;Sexual Health;Shapes;social determinants;social health determinants;structural determinants;Structural Racism;Structure;System;tool;Translational Research;translational study;trustworthiness;United States National Institutes of Health;Vision

PROJECT_TITLE: Research Consultation Services Core


PI_NAMEs: JENSEN-SMITH, HEATHER COLLEEN (contact)

PROJECT_TERMS: 3-Dimensional;4D Imaging;Acceleration;Anatomy;Animal Behavior;animal imaging;Animal Model;Animals;anti-cancer research;Atlases;base;Basic Science;Biological;Biological Models;Biological Phenomena;Cancer Center;Cancer Center Support Grant;Cancer Patient;Cells;Cessation of life;Clinical;clinical imaging;Clinical Trials;Collection;Complex;Consultations;contrast imaging;cost effective;Custom;Data;Data Analyses;data integration;digital;Educational workshop;Electron Microscopy;Equipment;Etiology;experience;Experimental Designs;fabrication;Funding;Funding Opportunities;Goals;Grant;IACUC;Image;image guided;imaging capabilities;imaging facilities;imaging modality;Imaging Techniques;Imaging technology;in vivo;in vivo imaging system;Individual;Influentials;innovation;insight;Institution;instrumentation;intravital imaging;intravital microscopy;irradiation;Life;Magnetic Resonance Imaging;Malignant Neoplasms;Microscopy;Modality;Molecular;Morphology;multi-photon;multidimensional data;Multimodal Imaging;multiphoton microscopy;Mus;Onset of illness;Operative Surgical Procedures;Optics;Organ;Organoids;outreach;photoacoustic imaging;Physiological;preclinical imaging;prospective;Reporter;repository;Research;Research Personnel;Research Proposals;Research Training;Resistance;Resolution;Resource Sharing;Resources;response;Sampling;single photon emission computed tomography;Site;Specialist;submicron;superresolution microscopy;System;Techniques;Three-Dimensional Imaging;Tissue imaging;Tissues;tool;Training;Training Programs;translational cancer research;Ultrasonography;ultrasound;United States National Institutes of Health;web site;Whole Organism;X-Ray Computed Tomography

PROJECT_TITLE: Preclinical Imaging Shared Resource


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: BROOKLYN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: PUBLIC HEALTH RELEVANCE: Everyday tasks such as reading and driving require a healthy eye movement control system in order to keep images in focus. The neuronal mechanisms that control voluntary eye movements are not well understood yet their disruption, due to disease or dysfunction, can have debilitating effects. The studies in this proposal seek to advance our understanding of these mechanisms with the goal of laying the groundwork for improved treatment when they go awry.

PI_NAMEs: RAMIREZ, ALEXANDRO D (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Ablation;Address;Affect;Anatomy;Animals;Automobile Driving;awake;Behavior;Behavioral;Brain;Calcium;career;Cell Communication;cell type;Cells;Cellular Morphology;Communication;Counseling;Data;Disease;Dyes;Electron Microscopy;Electrophysiology (science);Electroporation;experience;experimental study;Eye;Eye Movements;eye velocity;Foundations;fovea centralis;Functional disorder;Generations;Genetic;Goals;hindbrain;Human;Image;improved;Influentials;insight;interest;Involuntary Movements;Laboratories;Lasers;Leadership;Location;mathematical model;Mediating;medical schools;Membrane;Mentors;Midbrain structure;Modeling;Modernization;Molecular Biology;Morphology;Motor;Movement;neural;neural circuit;neural network;Neurons;Neurosciences;nonhuman primate;novel;oculomotor;Optics;optogenetics;Optokinetic nystagmus;Pathology;Pathway interactions;Phase;Population;Positioning Attribute;postsynaptic;Prosencephalon;public health relevance;Ramp;rapid eye movement;Reading;Recurrence;Research;Research Personnel;response;Retina;Role;Saccades;Signal Transduction;skills;Solid;Structure;symposium;Synapses;System;Technical Expertise;temporal measurement;Testing;therapy development;time interval;tool;Training;two-photon;vestibular system;Vision;voltage;Work;Zebrafish

PROJECT_TITLE: Understanding the Role of a Novel Cell Type in Triggering Voluntary Saccades


NIH_SPENDING_CATS: Cancer

PI_NAMEs: BORGSTAHL, GLORIA  (contact)

PROJECT_TERMS: 3-Dimensional;Active Sites;Amino Acids;Area;Binding Sites;Biological;Cancer Center;Cancer Center Support Grant;Cancer Science;Core Facility;Crystallization;Data;Data Collection;Disease;DNA Binding;Education;Ensure;Enzymes;experience;experimental study;Fee-for-Service Plans;Funding;Growth;Image;Individual;instrument;instrumentation;Isotope Labeling;Knowledge;Laboratories;Ligand Binding;Macromolecular Complexes;macromolecule;Malignant Neoplasms;member;Methods;Modification;Molecular;Molecular Conformation;Nebraska;novel therapeutics;Nuclear Magnetic Resonance;Postdoctoral Fellow;Process;Protein Chemistry;protein expression;protein protein interaction;protein purification;Proteins;Protocols documentation;Recombinant Proteins;Research;Research Personnel;Resource Sharing;Robotics;Roentgen Rays;Role;Sampling;screening;Services;shared decision making;Side;side effect;Signaling Molecule;structural biology;Structure;Students;Techniques;Training;transcription factor;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Biology Shared Resource


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: JACKSON

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PI_NAMEs: GRANGER, JOEY P. (contact)

PROJECT_TERMS: Address;Administrative Efficiency;Advisory Committees;African American population;Alabama;authority;Behavior Therapy;Biometry;Blood Glucose;blood glucose regulation;Blood Pressure;cardiometabolism;Cardiovascular system;Center for Translational Science Activities;Clinic;Clinical;clinical center;Clinical Research;Clinical Sciences;Clinical Trials;college;Communication;community advisory board;community engaged research;community engagement;Community Outreach;Data;Development;Disease;Disparity;Doctor of Philosophy;economic disparity;Effectiveness;Employee;Ensure;Epidemiology;Evaluation;experience;Extramural Activities;flexibility;Funding;Goals;Grant;Health;health disparity;Health Sciences;implementation science;improved;Infrastructure;Institution;interest;Investments;Leadership;Louisiana;Marketing;Measures;Medical center;meetings;Memory impairment;Mission;Mississippi;Monitor;multidisciplinary;National Institute of General Medical Sciences;neurodegenerative dementia;Obesity;Operations Research;organizational structure;Outcome;Performance;Periodicals;Persons;Phase;Pilot Projects;Policies;Population;population health;Population Research;Population Study;Procedures;Process;programs;Publications;Recommendation;Recording of previous events;Research;Research Activity;Research Design;research faculty;Research Personnel;Research Project Grants;Research Support;Resource Allocation;Resources;rural area;Rural Population;Scholars Program;Schools;scientific organization;Scientist;Services;square foot;Strategic Planning;Structure;success;Suggestion;telehealth;Time;translational engagement;Translational Research;translational research program;trend;Universities;Vascular Dementia;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: HALL, JOHN E (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Admission activity;Alabama;Alzheimer's Disease;Applications Grants;Bioinformatics;Cardiovascular Diseases;career;Center for Translational Science Activities;Centers of Research Excellence;Chronic Disease;Clinic;Clinical;clinical center;clinical investigation;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;college;community engaged research;Country;design;Development;Disease;Education;Emerging Technologies;Epidemiology;experience;Extramural Activities;Faculty;Faculty Recruitment;Feedback;Funding;Goals;Health;health care availability;health care disparity;Health Personnel;Health Services Accessibility;Healthcare;Illinois;improved;Infrastructure;Institution;Interdisciplinary Study;Kidney Diseases;Learning;Liver diseases;Louisiana;Malignant Neoplasms;Marketing;Master of Science;Medical center;Medical Students;meetings;member;Mentors;Mentorship;mid-career faculty;Minnesota;Minority Groups;Mississippi;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;patient population;Persons;Phase;Postdoctoral Fellow;Poverty;Productivity;Program Development;programs;racial health disparity;recruit;Research;research faculty;Research Methodology;Research Personnel;Research Support;sabbatical;Scholars Program;Scientist;Series;skills;Structure;success;Teleconferences;Time;Training;Training Programs;Translational Research;translational research program;translational scientist;undergraduate student;Universities;Visit;Work

PROJECT_TITLE: Professional Development Core


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Narrative Beginning in early childhood, children living in low-income circumstances are twice as likely to experience developmental delay in at least one domain including motor, cognitive, communication, and social-emotional; for Black and Latino children, this risk is compounded by structural racism. Further, racial and linguistic disparities exist in both diagnosis of delay and services received. To address these inequities, I will utilize Item Response Theory to design a new developmental assessment computer adaptive test that serves two functions: 1) determination of a child’s development status, and 2) inform primary care-based developmental support interventions and can be delivered in team-based care models.

PI_NAMEs: LILJENQUIST, KENDRA  (contact)

PROGRAM_OFFICER_NAME: GRIFFIOEN, MARI

PROJECT_TITLE: Advancing Equity in Early Childhood Developmental Screening Through Item Response Theory and User-Centered Design

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: HOUSTON

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

ORG_STATE: TX

PHR: Currently, no brief psychotherapy interventions for anxiety exist for VA primary care settings - where many Veterans seek care. Cognitive Behavioral Therapy (CBT) is a first line treatment for anxiety but Primary Care Mental Health Integration (PCMHI) providers need an intervention approach for anxiety disorders that is a brief, problem-focused, and fits into their system of care. The proposed 4-year, multisite trial will use a pragmatic randomized design to examine the effectiveness and implementation potential of a brief CBT intervention for anxiety either in-person or via VA Video Connect-Home (VVC-H), according to patient preference. Brief CBT will be delivered by existing PCMHI providers at three large VAMCs. Primary aims will examine the clinical effectiveness of bCBT vs. enhanced usual care for anxiety and quality of life outcomes at 4-, 8- and 12-month follow-ups. Secondary aims will predict treatment response and use of VVC-H. This project aligns with VA initiatives to use telehealth and implementation science to increase Veterans’ access to high-quality care.

PI_NAMEs: CULLY, JEFFREY ALEXANDER;FLETCHER, TERRI LYNN (contact)

PROJECT_TERMS: Address;Adoption;Anxiety;Anxiety Disorders;anxiety reduction;anxiety symptoms;anxiety treatment;Attention;attentional control;Brief Psychotherapy;care delivery;care preference;care seeking;care systems;Caring;Clinic;Clinical;Clinical effectiveness;Clinical Practice Guideline;Cognitive Therapy;Data;design;Diagnosis;Disease;E-learning;Effectiveness;effectiveness evaluation;Eligibility Determination;evidence base;Evidence based intervention;Evidence based treatment;flexibility;formative assessment;Functional impairment;Future;generalized anxiety;Goals;health related quality of life;Health Sciences;health service use;Health Services;Health Services Accessibility;Healthcare;Home;Homogeneously Staining Region;implementation outcomes;implementation science;Improve Access;improved;Individual;innovation;integrated care;Intervention;Interview;Leadership;Measurement;Medical;Medical Records;medical specialties;Mental Depression;Mental Health;Mental Health Services;Methods;multi-site trial;Outcome;Panic;Participant;Patient Education;Patient Preferences;Persons;Post-Traumatic Stress Disorders;practice setting;Pragmatic clinical trial;pragmatic randomized trial;pragmatic trial;Prediction of Response to Therapy;Primary Care;primary care patient;primary care setting;programs;Provider;psychiatric comorbidity;Psychotherapy;Quality of Care;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;reduce symptoms;service delivery;Services;SF-12;Site;skills;Social Phobia;Standardization;success;Suicide;Surveys;Technology;telehealth;Therapeutic Intervention;Time;Training;Training Programs;treatment as usual;treatment response;trial design;Veterans;Veterans Health Administration;Work

PROJECT_TITLE: A pragmatic trial of brief CBT for anxiety in VA primary care

STUDY_SECTION_NAME: HSR-4  Mental and Behavioral Health[HSR4]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: LIRETTE, SETH  (contact)

PROJECT_TERMS: Affect;Applications Grants;Area;Biometry;Biostatistical Methods;cardiometabolism;Centers of Research Excellence;Clinical;clinical center;Clinical Research;Collaborations;Communities;community based research;Data;data access;Data Analyses;data resource;Data Sources;data warehouse;Deep South;design;Disease;Doctor of Philosophy;Education;Electronic Health Record;Ensure;Epidemiology;epidemiology study;ethnic health disparity;Extramural Activities;Funding;Funding Opportunities;Goals;Grant;Health;implementation research;improved;insight;Institution;instrument;investigator training;Jackson Heart Study;Lead;Leadership;Manuscripts;Methods;Mississippi;National Institute of General Medical Sciences;Obesity;Perinatal;Pilot Projects;population health;Preparation;programs;Protocols documentation;Publications;Publishing;racial health disparity;randomized trial;randomized, clinical trials;Reporting;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rural Health;Scholars Program;Science;Services;Source;Statistical Computing;success;Surveys;telehealth;Training;Translational Research;translational research program;United States;uptake;Vulnerable Populations;Work

PROJECT_TITLE: Biostatistics, Epidemiology and Research Design (BERD) Core


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Prevention;Rehabilitation;Social Determinants of Health

ORG_DEPT: PHYSICAL MEDICINE & REHAB

PHR: PROJECT NARRATIVE The burden of visual disability in the U.S. is substantial, and the challenges confronted by several population subgroups are similar to those with visual disability in Thailand. We will use next-generation mapping and localization technology to support microservices that are embedded in a novel wearable, serving as a smart service system to improve the mobility and health of individuals in these populations. Our transdisciplinary and global team will use a patient-centered approach that leverages input from study participants and visual disability experts for improved function and usability, ultimately benefitting visually impaired persons worldwide.

PI_NAMEs: RIZZO, JOHN ROSS  (contact);VEDANTHAN, RAJESH

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: 3-Dimensional;3D world;Access to Information;Address;Adverse event;Anxiety;Area;Benchmarking;Blindness;Cells;Cities;citizen science;Cognition;cohort;college;Complex;Computer software;Computer Vision Systems;cost;Country;Cues;Data;Databases;Debility;digital twin;Dimensions;disability;Disparate;Ecology;Economic Burden;effectiveness evaluation;effectiveness testing;Elements;Employment;Enhancement Technology;Ensure;Environment;experience;falls;fear of falling;Feedback;Focus Groups;Foundations;Fracture;Freedom;Fright;functional assistance;functional improvement;Health;Health Promotion;higher education;Home Ranges;human-in-the-loop;Image;Immobilization;improved;improved mobility;improved outcome;Income;Individual;Infrastructure;innovation;Intelligence;Intervention;knowledge base;Length;Location;long bone;low and middle-income countries;Maps;Mechanics;Mental Depression;Modeling;next generation;novel;novel strategies;Outcome;Participant;patient oriented;Performance;Personal Satisfaction;Personal Space;Phase;Physical activity;Population;Positioning Attribute;Premature Mortality;Process;process evaluation;psychosocial;psychosocial outcome;Quality of life;reconstruction;Research;Research Personnel;Resource-limited setting;Resources;Risk;satisfaction;Semantics;sensor;Services;Signal Transduction;socioeconomics;Students;Subgroup;System;Techniques;Technology;Testing;Thailand;Time;Travel;Unemployment;Universities;urban area;usability;Visual disability;Visual impairment;Visually Impaired Persons;Visually Impaired Students;way finding;wearable device;wireless fidelity

PROJECT_TITLE: VIS4ION-Thailand (Visually Impaired Smart Service System for Spatial Intelligence and Onboard Navigation) - Resub - 1

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health

PI_NAMEs: COMPRETTA, CAROLINE E. (contact)

PROJECT_TERMS: Address;Advisory Committees;Advocate;Awareness;career;Clinic;Clinical;clinical center;Clinical Research;Collaborations;college;Communication;Communities;community academic partnership;community advisory board;community based participatory research;community based research;community engaged research;community engagement;Community Health;Community Networks;community organizations;Community Outreach;design;Development;Doctor of Pharmacy;Doctor of Philosophy;Education;experience;Faculty;Geographic Locations;Goals;Grant;Health;health disparity populations;health equity;Health Personnel;Health Priorities;high school;Holly;improved;Institution;Leadership;Learning;Manuscripts;Medical;Medical center;member;Mississippi;Names;outreach;Pilot Projects;practice-based research network;Preventive;programs;Public Health;Reaction Time;Reporting;Research;research and development;Research Personnel;Role;Rural Community;rural disparities;Schools;Series;Services;skills;Structure;student training;Students;success;Training;Translational Research;Universities;Urban Community;Vision;webinar;Work;working group;Writing

PROJECT_TITLE: Community Engagement and Outreach (CEO) Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Rural Health

PI_NAMEs: GOMEZ-SANCHEZ, CELSO ENRIQUE (contact)

PROJECT_TERMS: Address;Aldosterone;Area;Award;Cardiovascular Diseases;career;career development;Clinical;clinical center;Clinical Research;Collaborations;Collection;college;Communicable Diseases;community engaged research;community engagement;Community Outreach;community research;Cultural Backgrounds;Data;Data Collection;Development;Diabetes Mellitus;economic disparity;Eligibility Determination;Endocrinology;Equity;ethnic diversity;expectation;Expenditure;Extramural Activities;Faculty;Funding;gender diversity;Goals;Grant;Health;health disparity;Health Priorities;Health Services Accessibility;Home;improved;Individual;Infrastructure;Institution;interest;Kidney Diseases;Learning;Malignant Neoplasms;Maternal Health;Medical center;medically underserved population;meetings;member;Mentors;Mineralocorticoids;Mississippi;Monitor;multidisciplinary;Names;Obesity;Obesity associated disease;obesity management;Outcome;Phase;Pilot Projects;Population Research;Probability;Process;Program Development;programs;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Review Literature;Role;Rural;Scholars Program;Study Section;success;summer institute;Time;Training;translational engagement;Translational Research;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Pilot Projects Program


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative The proposed study will examine the implementation and impact of delivering two packaged status neutral interventions focused on enhancing access to HIV and employment-related services for justice-involved Black men who have sex with men in Illinois and Louisiana.

PI_NAMEs: BREWER, RUSSELL  (contact)

PROGRAM_OFFICER_NAME: POLLARD-BRANCHARD, SUZANNE LEE

PROJECT_TERMS: 2 arm randomized control trial;Achievement;Address;Adoption;black men who have sex with men;career development;Caring;Case Management;Case Manager;Client;Collaborations;collaborative approach;Communities;community advisory board;community engagement;community setting;Consolidated Framework for Implementation Research;contingency management;Continuity of Patient Care;cooking;cost;County;Coupled;Criminal Justice;Data;Dedications;Education and Outreach;Effectiveness;effectiveness evaluation;effectiveness/implementation study;Employment;Epidemic;epidemic preparedness;Equity;Evaluation;evidence base;experience;Feedback;financial incentive;Goals;HIV;HIV/AIDS;Illinois;implementation evaluation;implementation fidelity;implementation outcomes;Implementation readiness;implementation research;implementation science;implementation strategy;Improve Access;improved;Individual;Intervention;Justice;Learning;Logic;Louisiana;member;Mental Health;Methods;Modeling;Monitor;novel;Outcome;outreach;Participant;Penetration;Persons;Phase;Population;Positioning Attribute;pre-exposure prophylaxis;prevent;primary outcome;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recording of previous events;Research;Research Priority;response;secondary outcome;service delivery;Services;Site;skills;social;social health determinants;substance use;tool;Training;Unemployment;United States National Institutes of Health;uptake;Viral;Walking

PROJECT_TITLE: J-RISE: Relevant Implementation Strategies to Eliminate the social and structural barriers to HIV services among Justice-involved Black men who have sex with men

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(50)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PI_NAMEs: MASON, SARAH  (contact)

PROJECT_TERMS: Accountability;Advisory Committees;Annual Reports;Awareness;Clinical;clinical center;Clinical Research;Collaborations;Communities;community engagement;Community Participation;dashboard;Data;Data Analyses;data sharing;Databases;Decision Making;design;Doctor of Philosophy;Effectiveness;Empirical Research;Evaluation;Evaluation Research;Event;experience;Extramural Activities;Faculty;Feedback;Funding;Goals;Growth;Health;improved;Individual;Infrastructure;insight;Institution;institutional capacity;Lead;Leadership;Learning;Life;Maps;Measures;Mentors;Methods;Mississippi;model development;Modeling;Monitor;National Institute of General Medical Sciences;organizational climate;Outcome;Patient Care;Perception;Phase;Procedures;Productivity;program costs;programs;Public Health;Qualitative Evaluations;Reduce health disparities;Reporting;repository;Research;Research Personnel;Research Support;Resources;Series;Services;Specialist;success;Surveys;System;Time;tool;Translational Research;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Tracking and Evaluation Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Rural Health;Social Determinants of Health;Telehealth

PI_NAMEs: JONES, ALAN E (contact)

PROJECT_TERMS: Address;Adult;African American population;Alabama;Area;Atherosclerosis Risk in Communities;Award;Beds;Behavior Therapy;biobank;Bioethics;Biometry;Budgets;Cardiometabolic Disease;career;Clinic;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Sciences;Clinical Services;clinical translation;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Unit;cohort;Cohort Studies;Collaborations;community collaboration;community engagement;Community Outreach;community research;Consult;Data;data warehouse;design;Development;Disparity;economic disparity;Education;electronic consent;electronic health data;Emergency Medicine;Enrollment;Epidemiology;epidemiology study;ethnic health disparity;experience;Extramural Activities;Funding;Goals;Growth;Health;health disparity;Health Sciences;Hospitals;implementation facilitation;implementation research;implementation science;improved;Industry;Informed Consent;Infrastructure;Institution;Institutional Review Boards;Investigation;Jackson Heart Study;Link;Longitudinal Studies;Louisiana;Low Income Population;Mississippi;neighborhood disadvantage;Obesity associated disease;Outcome;Participant;participant retention;Pathogenesis;Patient Recruitments;Patients;Persons;Phase;Pilot Projects;poor health outcome;Population;population health;Positioning Attribute;Procedures;Process;Productivity;professor;programs;Protocols documentation;racial health disparity;recruit;Research;research and development;Research Design;Research Ethics;Research Personnel;Research Project Grants;Research Project Summaries;research study;Research Training;Resources;responsible research conduct;Risk;Rural;rural area;Rural Health;sample collection;Scholars Program;Services;sound;Standardization;Stream;success;Technology;telehealth;Tissue Banks;Training;Translational Research;United States Health Resources and Services Administration;Universities;Work

PROJECT_TITLE: Research Services Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: AUGUSTA

ORG_DEPT: PATHOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE TO PUBLIC HEALTH The prognosis for GBM patients remains dismal and there is an urgent unmet need for novel therapies. The first oncolytic virus to be approved by the FDA is an oncolytic HSV whose use is prescribed for melanoma patients. To increase the utility of this novel approach for brain tumor patients we propose to create and optimize a lead HSV derived virus for development for clinical intracranial use without affecting neurologic function.

PI_NAMEs: KAUR, BALVEEN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: ADAMTS;adult neurogenesis;Affect;angiogenesis;Animals;Behavior;Brain;Brain Neoplasms;cancer cell;CCL2 gene;Cell Maintenance;Cell Maturation;Cell Survival;Cells;Chemotherapy and/or radiation;clinical development;cytotoxicity;Data;Development;Devices;Disease;Drug usage;efficacy evaluation;Environment;FDA approved;gamma secretase;Glioblastoma;Glioma;Goals;Grant;Growth;Herpesvirus 1;Human;Immune;Immunity;Immunocompetent;immunodeficiency;Immunotherapeutic agent;improved;Individual;Infection;inhibitor;Intracranial Neoplasms;Invaded;irradiation;Japan;Lead;Ligand Binding;Ligands;Marketing;Mediating;Melanoma patient;Membrane;Memory;Memory impairment;memory process;Modeling;monocyte;monomer;Mus;Myeloid Cells;Myeloid-derived suppressor cells;neoplastic cell;Nervous System Physiology;Neurologic;notch protein;Notch Signaling Pathway;novel strategies;novel therapeutics;Oncolytic;oncolytic herpes simplex virus;oncolytic virotherapy;Oncolytic viruses;Operative Surgical Procedures;Oral;Outcome;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Peptides;Phenotype;Play;Prognosis;programmed cell death protein 1;Public Health;Radiation;Radiation therapy;receptor;recruit;Resistance development;response;Role;Safety;Signal Transduction;Simplexvirus;stem cells;stemness;synergism;T cell differentiation;T-Lymphocyte;temozolomide;Testing;Therapeutic;Toxic effect;Transcriptional Activation;Treatment Efficacy;tumor;Tumor Immunity;tumor progression;Tumor-associated macrophages;Virotherapy;Virus;virus development

PROJECT_TITLE: Next Gen Virotherapy for GBM


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_CITY: MILWAUKEE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Microphthalmia, anophthalmia and coloboma (MAC) are severe ocular phenotypes characterized by a reduction in size or absence of the eye or a gap (hole) involving ocular structures. This project will study the genetic mechanisms of MAC using human samples and zebrafish models. The results of this study will increase our understanding of MAC spectrum, generate relevant animal models, and allow for the development of advanced therapies in the future.

PI_NAMEs: SEMINA, ELENA V (contact)

PROJECT_TERMS: 3q29;Advanced Development;Affect;Animal Model;Anophthalmos;BCL2L1 gene;Bilateral;cohort;Collection;Coloboma;Complex;Copy Number Polymorphism;Data;de novo mutation;defined contribution;Detection;Development;Disease;Dissection;DLG1 gene;DNA;dosage;Enrollment;Exhibits;Eye;Eye Development;Family;Future;Genes;genetic disorder diagnosis;Genetic study;Genomic Segment;Genomics;Health;Human;human disease;Individual;Inherited;Literature;Live Birth;Maps;Microphthalmos;Modeling;novel;Orthologous Gene;Pathway interactions;Patients;Penetrance;Phenotype;proband;Recurrence;Reporting;Role;Sampling;Structure;success;Testing;Time;Variant;Zebrafish

PROJECT_TITLE: Genomic duplications in anophthalmia, microphthalmia and coloboma


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative Sleep disordered breathing (SDB) is a significant public health concern that impacts 10.5-17.1% of youth. Non- Latinx Black children are 4-6 times more likely than non-Latinx White children to evidence SDB; and Black children also experience increased OSAS severity and subjective sleepiness when diagnosed, and less neurobehavioral improvement following OSAS treatment. The purpose of this project is to identify socio- ecological factors at the individual child, family, healthcare setting, neighborhood, and broader socio-cultural levels contribute to racial disparities in SDB consequences and timely therapeutic options in Black and White children with SDB.

PI_NAMEs: TAPIA, IGNACIO ESTEBAN (contact)

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: Adverse event;Age;Apnea;Asthma;asthma exacerbation;atopy;Attention;Behavior;Behavioral;behavioral health;Black race;Body mass index;cardiometabolism;Characteristics;Child;Child Health;Child health care;Child Rearing;Childhood;Chronic;Clinical;clinical encounter;Cognitive;Communication;comorbidity;contextual factors;Development;Diagnosis;Disadvantaged;Disparity;disparity reduction;Drowsiness;Education;effective intervention;environmental tobacco smoke exposure;ethnic disparity;Ethnic Origin;executive function;Exhibits;experience;externalizing behavior;Family;Goals;Health;Health behavior;health care availability;health care settings;health disparity;health literacy;Healthcare;Heart Hypertrophy;Hospitals;Hour;Hyperactivity;Hypertension;Impairment;implicit bias;improved;Incidence;Income;indexing;Individual;innovation;Intervention;Knowledge;Laboratories;Link;low socioeconomic status;Measures;Medicine;Memory;Methods;mortality risk;motor control;Neighborhoods;neurobehavior;neurobehavioral;Noise;novel;Obesity;Obstructive Sleep Apnea;Occupations;Otolaryngologist;Outcome;Outcomes Research;Parents;patient oriented;Patients;Pattern;pediatrician;Pediatrics;perceived discrimination;Perception;physical conditioning;Polysomnography;poor sleep;Postoperative Period;premature;Prevalence;Prospective Studies;Provider;Public Health;Quality of life;Race;racial bias;racial difference;racial disparity;Recommendation;recruit;Research;respiratory;Risk;Role;Sampling;Seminal;Severities;sex;Sleep;Sleep Apnea Syndromes;sleep behavior;Sleep Deprivation;sleep health;Snoring;social culture;Socioeconomic Status;standard care;Stress;Symptoms;Testing;Therapeutic;Treatment outcome;Trust;Variant;vigilance;Visit;Youth

PROJECT_TITLE: Investigating socio-ecological factor in pediatrics sleep-related health Disparities


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAINT LOUIS

ORG_DEPT: CHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The proposed research is important to public health because it will lead to the critical understanding of how nucleic acids recognize ligands and drugs in terms of the basic thermodynamics underlying intermolecular interactions. Use of advanced force fields will allow computation of binding energetics to within an accuracy of 1 kcal/mol. The methodology and calculations proposed will help enable a new era of drug design where unique chemical structures are accurately designed and evaluated by computational means alone, especially for the targeting of small molecules-RNA interactions.

PI_NAMEs: PONDER, JAY  (contact);REN, PENGYU

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Acids;Address;Algorithms;Anti-Bacterial Agents;Anti-viral Agents;Antibiotics;aptamer;Area;base;behavior prediction;Binding;biological systems;Biology;cancer therapy;Carbohydrates;Cell Nucleus;Cells;Charge;Chemical Structure;Chemicals;combat;Communities;Complement;Complex;Computer Models;Computer software;computerized tools;Coupled;Coupling;COVID-19 pandemic;COVID-19 vaccine;Data;design;Development;Disease;DNA;Drug Design;Electrostatics;enthalpy;Entropy;Environment;experimental study;Flavin Mononucleotide;flexibility;Free Energy;Future;G-Quartets;Generations;Genomics;group I ribozyme;Growth;hypercholesterolemia;improved;inorganic phosphate;insight;intermolecular interaction;Ions;Life;Ligand Binding;Ligands;Machine Learning;Malignant Neoplasms;Medical;Medicine;Messenger RNA;Metal Ion Binding;Methodology;Methods;MicroRNAs;Modeling;models and simulation;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;Muscular Dystrophies;Mutation;neural network;Neurodegenerative Disorders;next generation;novel;novel therapeutics;Nucleic Acid Binding;nucleic acid structure;Nucleic Acids;Nucleotides;Oligonucleotides;pandemic disease;Penetration;Performance;Pharmaceutical Preparations;Pharmacologic Substance;Physics;predictive tools;Property;Proteins;Pseudouridine;Public Health;quantum chemistry;Research;Ribose;RNA;RNA vaccine;Rotation;Sampling;simulation;simulation software;Site;small molecule;Specificity;Structure;System;Tetrahymena;Therapeutic;Therapeutic Agents;Thermodynamics;tool;vaccine distribution;Vertebral column;Water;Work

PROJECT_TITLE: Development of a Next-Generation Nucleic Acid Force Field


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: Newark

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative Cellular stress response is a common pathway for cells to respond to daily stress. It is dysregulated in many human diseases accompanied by disrupted daily rhythms. Understanding its interactions with the body clock is therefore fundamentally important for understanding general principles of biological systems and for treating these diseases using its FDA-approved modulators.

PI_NAMEs: CAO, RUIFENG (RAY)  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Address;Animals;Behavioral;Behavioral Assay;Binding;biological adaptation to stress;Biological Clocks;Biological Process;biological systems;Bioluminescence;Brain Diseases;Cell Physiology;Cells;Cellular Metabolic Process;Cellular Stress;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Complex;conditional mutant;Coupled;Couples;Data;Disease;Dissociation;efficacy evaluation;Endoplasmic Reticulum;Eukaryotic Initiation Factors;Exhibits;FDA approved;Functional disorder;Gene Expression;Gene Proteins;Genes;Genetic;Health;Health Promotion;Homeostasis;Homologous Gene;Human;Human body;human disease;imprint;improved;inhibitor;innovation;Knockout Mice;Knowledge;Light;Link;loss of function;Metabolism;Modeling;Molecular;mouse genetics;mouse model;mRNA Translation;Mus;Mutant Strains Mice;Neuronal Differentiation;Neurons;Neurospora;novel;Organism;Pathway interactions;Patients;Periodicity;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Phenotype;Phosphorylation;Phosphotransferases;physiologic stressor;Physiology;polysome profiling;Prokaryotic Initiation Factor-2;Property;protein kinase R;protein misfolding;Proteins;Publishing;Regulation;Reporting;Research;response;Role;Running;Signal Transduction;Slice;Speed;Stress;stressor;Testing;Time;tissue regeneration;tool;Transcript;transcriptome sequencing;translatome;Work

PROJECT_TITLE: Integrated stress response and the circadian clock

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Behavioral and Social Science;Diabetes;Mental Health;Pediatric;Social Determinants of Health

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Despite decades of research about the centrality of behavioral and psychosocial factors in supporting health and mental health outcomes of people with diabetes, there are few empirically supported interventions in the field, and a larger, more diverse field of well-trained behavioral scientists is needed to make progress. This K26 proposes to expand Dr. Marisa Hilliard’s capacity to provide in-depth, strengths-based, culturally aware research mentorship to a diverse, multidisciplinary group of graduate students, postdoctoral fellows, and other early career researchers interested in behavioral research for youth and young adults with type 1 diabetes and their families. To strengthen her skills for working with a highly diverse pool of mentees, Dr. Hilliard will engage in targeted research mentor training experiences and receive individual coaching from two established mentorship experts, focusing on fostering an anti-racist, culturally aware mentorship approach that is tailored to learners’ individual strengths, developmental level, and goals.

PI_NAMEs: HILLIARD, MARISA ELLEN (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Achievement;Adherence;Adolescence;Adult;American;American Psychological Association;anti-racism;Applied Skills;Attention;Award;Awareness;Behavior;behavior change;Behavior Therapy;Behavioral;Behavioral Research;Behavioral Sciences;career;career development;Caring;Characteristics;Child Psychology;Childhood;Childhood diabetes;Clinical;clinically relevant;Collaborations;college;Complex;Country;Data;Data Analyses;Development;diabetes management;Diabetes Mellitus;Diagnosis;disability;Discipline;Disease;Doctor of Philosophy;early adolescence;Educational workshop;emerging adulthood;Endocrinology;equity, diversity, and inclusion;Ethnic Origin;experience;Faculty;Family;Family member;Fellowship Program;Focus Groups;Fostering;Foundations;Funding;Future;Glucose;Glycosylated hemoglobin A;Goals;graduate school;graduate student;Grant;Health;Health behavior change;health related quality of life;Health Sciences;improved;improved outcome;Individual;Institution;Insulin-Dependent Diabetes Mellitus;interest;Interest Group;Intervention;Intervention Trial;Learning Skill;lens;Life;Measures;Medical;Medicine;Mental Health;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Minority;Mission;Modeling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Newly Diagnosed;Outcome;pediatric department;Pediatric Hospitals;Pediatric Research;Period Analysis;Persons;Population;post-doctoral training;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;Principal Investigator;Professional Organizations;programs;psychologic;Psychologist;Psychology;psychosocial;Psychosocial Factor;psychosocial wellbeing;Public Health;Quality of life;Race;recruit;Regimen;Research;Research Activity;Research Personnel;Research Project Grants;Research Support;Research Training;resilience;Risk;Science;Scientist;secondary analysis;Self Management;Site;skill acquisition;skills;Societies;socioeconomics;Students;success;Targeted Research;Texas;Time;Training;Training Programs;treatment adherence;Treatment Protocols;Underrepresented Populations;Underrepresented Students;young adult;Youth

PROJECT_TITLE: Behavioral Research Mentorship in Diabetes for Early Career Scientists from Diverse and Underrepresented Groups.


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Hematology;Human Genome;Lymphatic Research;Lymphoma;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Environmental exposures with carcinogenic potential are a concern to individuals living in Minnesota, including poly- and perfluoroalkyl substances (PFAS), glyphosate (RoundUp), and radon. The impact of these exposures may be especially relevant for populations that have been typically under-represented in existing cohort studies such as individuals living in rural areas, racial/ethnic minorities, and immigrants. We are proposing to launch a new cohort study to investigate these relevant exposures and risk of malignancy.

PI_NAMEs: NELSON, HEATHER HAMMOND;PETERSON, LISA A;POYNTER, JENNY N. (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Acceleration;Address;Adult;Advocacy;Age;Agriculture;Air;Ancillary Study;Automobile Driving;biobank;Biological Markers;Blood;Cancer Center;Cancer Etiology;cancer risk;cancer type;carcinogenicity;Carcinogens;Cells;Chemicals;Child;Classification;cohort;Cohort Studies;Collection;Communities;community empowerment;community engagement;Community Health Education;Community Outreach;County;Data;de novo mutation;Development;Disparity;Dysmyelopoietic Syndromes;early detection biomarkers;Environmental Exposure;Epigenetic Process;epigenomics;ethnic minority;Ethnic Population;Exposure to;Family;Family Study;Fingers;Funding;geographic difference;glyphosate;Gold;Hair;Hematologic Agents;Hematologic Neoplasms;Hematology;Hematopoiesis;Heme;Heritability;High Prevalence;high risk;Hispanic;Household;Human;Immigrant;Immigrant community;Immune;Immunity;Immunologic Markers;Incidence;Individual;innovation;interest;International Agency for Research on Cancer;Iowa;leukemia;Link;Longterm Follow-up;Lymphoma;Malignant Neoplasms;manufacture;Measures;Methodology;Methods;microbiome;Minnesota;neoplasm registry;Non-Hodgkin's Lymphoma;Outcome;Participant;Patient Recruitments;Pesticides;Phase;pilot test;Poly-fluoroalkyl substances;Population;Prevalence;Prospective cohort;racial minority;racial population;Radon;Recording of previous events;recruit;Reporting;Research;Research Institute;residence;Risk;Risk Factors;Role;Roundup;Rural;rural area;Rural Community;Serum;Silicon;Silicones;study population;System;Technology;Testing;Time;Underrepresented Populations;Universities;urban area;Urine;Venous;virtual;Water;wearable device;Wisconsin

PROJECT_TITLE: The 10,000 Families Cohort: a new study to understand the environmental causes of cancer


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Cerebrovascular;Genetics;Human Genome;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Dysfunction of the cerebrovasculature is a common factor in many diseases of the brain, including neurodegenerative diseases, cerebrovascular diseases, as well as in aging. Next-generation models of the cerebrovasculature will enable study of the underlying physical and biochemical processes that regulate these processes in health and disease. The overall goal of this project is to use zonation- and age-specific intrinsic and extrinsic cues to reverse engineer human cerebrovascular models, and to use these models to understand cerebrovascular phenotype during aging.

PI_NAMEs: HEIMAN, MYRIAM ;SEARSON, PETER C (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: 3-Dimensional;age related;age related changes;aged;Aging;aging related disease;arteriole;Automobile Driving;Biochemical Process;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain Diseases;brain endothelial cell;brain health;candidate identification;candidate validation;Cell Line;Cells;cellular transduction;cerebrovascular;Cerebrovascular Disorders;Cerebrovascular system;Collaborations;Cues;Development;Disease;Disease Progression;Engineering;Functional disorder;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genetic Screening;Genomics;Geometry;Goals;Health;Human;Human Engineering;In Vitro;induced pluripotent stem cell;Intrinsic factor;lentivirally transduced;Libraries;Maintenance;Modeling;Molecular;Neurodegenerative Disorders;next generation;Nutrient;Older Population;Pathology;Perfusion;Phase;Phenotype;physical process;Play;Process;protein expression;Resected;response;Reverse engineering;Role;Serum;shear stress;single nucleus RNA-sequencing;Source;stem cell technology;Supporting Cell;Tissue Engineering;Tissues;trafficking;transcription factor;transcriptomic profiling;transcriptomics;Translations;venule;wasting;Western Blotting

PROJECT_TITLE: Reverse engineering zonation-specific and age-specific iPSC-derived cerebrovascular models based on transcriptomic profiling of the human brain


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Services;Mental Health;Mental Illness;Patient Safety;Prevention;Serious Mental Illness;Suicide;Suicide Prevention;Violence Research

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative Approximately one-quarter of all suicides occur among patients who are within 3 months of discharge from a psychiatric hospital. Intensive outpatient programs/partial hospitalization programs (IOP/PHPs) have been instituted to help care for high-risk patients who do not fully require 24-hour supervision, but there is a tremendous amount of regional variation in access; while IOP/PHPs are readily available in some regions of the United States, they are virtually nonexistent in others. Using linkage with the National Death Index, this project will examine the effectiveness of IOP/PHP as a service intervention to reduce the risk of suicide death in the post-hospital discharge period compared to standard outpatient follow-up care among Medicaid recipients.

PI_NAMEs: RHEE, TAEHO GREGORY;WILKINSON, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Accident and Emergency department;Admission activity;Ambulatory Care;Area;barrier to care;Caring;Cessation of life;Clinical;clinical care;clinical effect;cohort;combat;Country;Data;Data Set;Data Sources;Databases;Day Care;Discharge Plannings;Dissemination and Implementation;Effectiveness;effectiveness evaluation;Emergency department visit;Event;Feeling suicidal;follow-up;Future;General Population;group intervention;Growth;Health Resources;Health Services Accessibility;Health system;high risk;Hospital Units;Hospitalization;Hospitals;Hour;improved;indexing;Individual;inpatient psychiatric treatment;inpatient service;Inpatients;Institution;Lead;Leadership;Length of Stay;Link;Location;Managed Care;Measures;Medicaid;Medical Records;Mental Health;Meta-Analysis;mortality;National Institute of Mental Health;Observational Study;Outcome;outpatient programs;Outpatients;Patients;Pattern;Persons;policy implication;Policy Maker;premature;Process;programs;Proliferating;protective effect;Psychiatric Hospitals;psychologic;Public Health;Quality of Care;reducing suicide;Reporting;Research;Risk Factors;Risk Reduction;Sampling;service intervention;service programs;Services;social;suicidal morbidity;suicidal risk;Suicide;suicide rate;Supervision;Surveys;System;Testing;Time trend;United States;Variant;virtual;Visit;Withdrawal

PROJECT_TITLE: Examining Intensive Outpatient Programs as a Potential Mechanism to Reduce Suicide Risk During the Post-Hospitalization Period Among Medicaid Recipients

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Health Services;Neurodegenerative;Neurosciences;Primary Health Care

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Optical coherence tomography (OCT) is an essential imaging technique for management of many common eye conditions, including diabetic retinopathy, age-related macular degeneration, and glaucoma. OCT has a limited eye screening role outside of ophthalmology offices due to personnel and training barriers, however. This project seeks to develop a robotic point-of-care approach for semi-automated OCT imaging that may eventually enable chronic eye disease surveillance in primary care offices and non-specialist clinics.

PI_NAMEs: DRAELOS, MARK  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Affect;Age related macular degeneration;Algorithms;American;Anatomy;Area;arm;Attenuated;attenuation;base;Blinded;Blindness;Blinking;career;career development;Caring;Chronic;Clinic;clinic ready;Clinical;Computer software;Dedications;design;Detection;Deterioration;Device or Instrument Development;Diabetic Retinopathy;Diagnostic Procedure;digital;Disease;Disease Management;Disease Surveillance;Environment;Excision;Exhibits;experience;Eye;Eye diseases;Face;feeding;flexibility;Funding;Generations;Glaucoma;Hand;Head;head-to-head comparison;Health Personnel;Human Resources;Image;image processing;imaging modality;imaging platform;imaging system;Imaging Techniques;improved;instrument;Internships;Laboratories;Machine Learning;Measurement;Measures;Mechanics;Medical;Medical Device;medical schools;Medical Technology;Mentors;Morphologic artifacts;Motion;next generation;novel;novel strategies;operation;ophthalmic examination;Ophthalmologist;Ophthalmology;Optical Coherence Tomography;Optics;Patient imaging;Patient Participation;Patients;Patients' Rooms;Phase;point of care;portability;Positioning Attribute;Predisposition;prevent;Primary Care;primary care provider;primary care setting;Process;programs;prototype;Research;research clinical testing;Research Personnel;Residual state;Retina;Retinal Diseases;Robot;Robotics;Role;routine screening;Sampling;Scanning;Scientist;screening;Signal Transduction;skills;Specialist;standard of care;Structure;System;Techniques;Technology;technology development;teleophthalmology;Testing;Time;tool;Torque;Training;Training Programs;Translating;Vision;Visit;visual tracking

PROJECT_TITLE: Robotic Point-of-Care OCT


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This project investigates distinctive roles of PDGF and FGF signaling in retinal astrocytes and angiogenesis. It is expected to enhance our understanding of signaling crosstalk in eye development and guide future efforts in treating ocular diseases.

PI_NAMEs: TAO, CHENQI  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Actins;Adaptor Signaling Protein;angiogenesis;Angiogenic Factor;Astrocytes;autocrine;Behavior;Binding;Blood-Retinal Barrier;cell motility;cohort;Coloboma;Data;Development;Disabling;Disease;Endothelial Cells;Endothelium;Eye Development;Eye diseases;Family;Fibroblast Growth Factor;Fibroblast Growth Factor Receptors;Future;Genes;Genetic;Glaucoma;Gliosis;gliovascular;Goals;Growth Factor;Guanosine Triphosphate Phosphohydrolases;Health;Homeostasis;Image;Impairment;Invaded;Knock-out;Ligands;Maintenance;MAP Kinase Gene;Mediating;migration;Molecular;mouse model;mutant;Mutant Strains Mice;Neonatal;Nervous System;neural;Nuclear;Orphan;paracrine;Pathway interactions;Physiology;PIK3CG gene;Platelet-Derived Growth Factor;Platelet-Derived Growth Factor Receptor;Play;polymerization;Polymers;Receptor Protein-Tyrosine Kinases;recruit;Retina;Retinal Ganglion Cells;Retinopathy of Prematurity;rho;Role;scaffold;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Testing;Tissues;transcription factor;transcriptomics;transmission process;Vascularization

PROJECT_TITLE: Receptor tyrosine kinase signaling in astrocyte migration and angiogenesis

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Non-human primates (NHP) such as baboon, cynomolgus macaque, rhesus macaque, and vervet are susceptible to the same age-related health challenges and diseases as humans. The overall aging trajectory in NHP is also influenced by stressors and lifestyle similar to humans. Research in NHP allows for controlled environments, providing longitudinal data with less “noise” than in human studies. Identification of molecular mechanisms underlying aging in multiple NHP species will significantly increase the likelihood that these mechanisms translate to human aging. The goals of this study are to generate an integrated NHP resource to support aging studies (R21 phase), and to demonstrate the utility of this resource for comparative omic studies in four NHP species (R33 phase).

PI_NAMEs: COX, LAURA A (contact);HOWARD, TIMOTHY D;SHIVELY, CAROL A.

PROGRAM_OFFICER_NAME: MORO, MANUEL H

PROJECT_TERMS: Adult;Age;age related;Aging;aging biomarker;aging mechanism;Alzheimer's Disease;Animals;biobank;Biological;biological age;Biological Clocks;Blood;Blood specimen;Cardiovascular Diseases;Cardiovascular Models;Chronology;Clinical;clinical development;Clinical Markers;clinically relevant;cohort;comparative;Computer software;Controlled Environment;Data;data harmonization;data management;Data Management Resources;data sharing;Data Storage and Retrieval;Databases;Dementia;Development;Diabetes Mellitus;Diet;Dietary Intervention;Disease;DNA Methylation;Equipment and supply inventories;Female;Funding;Future;Gene Expression;Genetic;genetic pedigree;Genetic Predisposition to Disease;Genotype;Goals;Health;Hormones;Human;human disease;immune function;Interdisciplinary Study;Intervention;Life Cycle Stages;life span;Life Style;Liver;Macaca fascicularis;Macaca mulatta;male;Measures;Metabolic;Metabolic Diseases;Modeling;Molecular;Molecular Profiling;Monkeys;Noise;nonhuman primate;normal aging;Obesity;open source;Paper;Papio;Phase;Phenotype;phenotypic data;Physiological;Plasma;Predisposition;Primates;Process;Proteins;quantification of aging;Radiation exposure;Records;Research;Research Personnel;Resources;Rhesus;RNA;sample archive;Sampling;Stress;stressor;Tissues;Translating;United States National Institutes of Health;vervet;Work

PROJECT_TITLE: Development of a Wake Forest Multi-Species NHP Biorepository to Support Interdisciplinary Aging Studies


NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Project Narrative Cancer can be caused by activating alterations in receptor tyrosine kinases, such as EGFR or HER2. This proposal aims to improve our understanding of the functional consequences of EGFR and HER2 activation and resistance to HER-targeted inhibitors, thereby accelerating the development of new therapeutic strategies for treating patients with alterations in these genes.

PI_NAMEs: HAYES, TIKVAH K (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Acceleration;Activities of Daily Living;Advisory Committees;Biological Assay;Biology;Bypass;Cancer Biology;cancer genomics;cancer imaging;Cancer Model;Cancer Patient;career;career development;Cell Line;Cell Proliferation;Cell Survival;Chimeric Proteins;Classification;Clinical;clinical investigation;Collaborations;Communication;Dana-Farber Cancer Institute;Data;Dependence;design;Development;Dimerization;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;Family;functional genomics;Generations;Genes;genetic approach;Genetic Screening;Genomics;Goals;Grant;Heterodimerization;Homo;Human;image processing;Immunofluorescence Immunologic;improved;In Vitro;in vivo;in vivo Model;inhibitor;inhibitor therapy;Injections;Investigation;Laboratories;lapatinib;Leadership;Learning;Lung;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Mentorship;Methods;Missense Mutation;Modeling;Molecular Biology;Molecular Target;mortality;mouse model;Mutagenesis;mutant;Mutate;Mutation;novel therapeutic intervention;Nude Mice;Oncogenes;Oncogenic;Organoids;Patient Care;patient subsets;Patients;pharmacologic;Phase;Point Mutation;Postdoctoral Fellow;pre-clinical;receptor;Receptor Protein-Tyrosine Kinases;Relapse;Reporting;Research;Resistance;resistance mutation;Role;Science;Signal Transduction;Stains;STAT1 gene;structural biology;targeted treatment;Techniques;Therapeutic;tissue processing;Training;tumor;tumor growth;tumor initiation;tumor xenograft;tumorigenesis;Tyrosine Kinase Inhibitor;Validation;Variant;variant of unknown significance;Writing;Xenograft procedure

PROJECT_TITLE: Functional Characterization of HER Family Variant Biology and Resistance in Cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: SHARE P01 NARRATIVE The SHARE program will develop, test and implement behavioral interventions to improve alcohol use and viral load in youth living with HIV in Florida. At the foundation is a a community engagement core in a state-wide diversity initiative to maximize public health impact.

PI_NAMEs: MACDONELL, KAREN ;NAAR, SYLVIE  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Address;Adult;Age;age group;alcohol comorbidity;Alcohol consumption;alcohol monitoring;Alcohols;Basic Behavioral Science;Behavior;Behavior Therapy;Behavioral;Behavioral Sciences;Behavioral trial;Big Data;Caring;Chronic Disease;Communities;community academic partnership;community engagement;comorbidity;comparative effectiveness trial;Competence;culturally appropriate intervention;Data Science Core;Decision Making;Development;Disease Progression;efficacious intervention;Electronic Health Record;emerging adult;emerging adulthood;Ensure;Epidemic;expectation;Face;Feedback;Florida;Foundations;Goals;Health;HIV;HIV diagnosis;HIV Infections;HIV/AIDS;improved;Individual;innovation;Intervention;intervention program;Life;Life Style;Link;Literature;medication compliance;Mental Health;Methods;Modeling;Monitor;Motivation;Neurocognition;new technology;older adult;Outcome;Persons;Phase;Physical activity;physical conditioning;Problem Solving;Program Research Project Grants;programs;Psychological reinforcement;psychosocial;Public Health;recruit;Research;Research Project Grants;Risk;Risk Behaviors;Risk Taking;Role;scale up;secondary analysis;Self Management;Self-control as a personality trait;skills;Sleep;social;social stigma;Stress;Substance abuse problem;substance use;symptom management;Technology;Testing;therapy design;therapy development;Tobacco;transition to adulthood;Translating;translational pipeline;translational study;Translations;transmission process;treatment as prevention;United States;United States National Institutes of Health;Viral;Viral Load result;Work;Youth

PROJECT_TITLE: SHARE Program: Innovations in Translational Behavioral Science to Improve Self-management of HIV and Alcohol Reaching Emerging adults


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Rural Health;Social Determinants of Health;Substance Misuse;Underage Drinking

PI_NAMEs: NAAR, SYLVIE  (contact)

PROJECT_TERMS: Address;Administrative Efficiency;Administrator;Age;Alcohol abuse;Alcohol consumption;alcohol research;Alcohols;Behavioral Sciences;Budgets;catalyst;Chronic Disease;Collaborations;Communication;Communities;community partners;comorbidity;Data;Data Set;data sharing;design;Development;Electronic Health Record;emerging adult;emerging adulthood;Encapsulated;Ensure;Environment;Epidemic;Epidemiology;Ethnic Origin;experience;Faculty;Florida;Foundations;Gender;Geography;health disparity;HIV;HIV Infections;HIV/AIDS;Human Resources;improved;innovation;Institutional Review Boards;Leadership;Libraries;meetings;Mentors;minority health disparity;Monitor;multidisciplinary;Outcome;Persons;Pilot Projects;Policies;Population Heterogeneity;programs;Race;Research;Research Personnel;Resources;Rural;Science;Self Management;Seminal;Strategic Planning;substance use;synergism;Training;Universities;Update;Vulnerable Populations;Work;Youth

PROJECT_TITLE: SHARE Administrative Core


ORG_CITY: PHILADELPHIA

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: The proteins mediating mitochondrial calcium uptake have been identified but many of their roles in calcium transport and beyond remain an enigma. We will test if the MICU regulators of calcium uptake are important for individual cells’ calcium signal fingerprints, for redox homeostasis and for fusion-fission and cristae dynamics of the mitochondria. These studies will inform on the pathways by which MICUs support mitochondrial structure, dynamics and signaling, and on the pathogenesis initiated by their perturbations.

PI_NAMEs: HAJNOCZKY, GYORGY  (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Acute;Biological Assay;Calcium;Calcium Signaling;calcium uniporter;Cell Death;cell injury;Cell Line;Cell Physiology;Cells;Chronic;Complex;Crista ampullaris;Cytoplasm;Data;Dependence;dimer;Disease;driving force;Endoplasmic Reticulum;Energy Metabolism;Environment;extracellular;Fingerprint;Functional Imaging;Gatekeeping;Genetic;Genetic Diseases;Genetic Models;Glutathione Disulfide;Heterogeneity;Homeostasis;human disease;Human Genetics;Hydrogen Peroxide;imaging approach;Individual;Inner mitochondrial membrane;Ischemia;Link;Liver;Malignant Neoplasms;Mediating;Membrane Potentials;Metabolism;Mitochondria;Mitochondrial Matrix;mitochondrial membrane;Modification;Morphology;mouse genetics;Mus;Muscle;Mutation;novel;Organ;Organelles;Oxidation-Reduction;Pathogenesis;Pathway interactions;Patients;Pattern;Perinatal mortality demographics;Permeability;Proteins;Reactive Oxygen Species;Reperfusion Therapy;Resolution;Rest;Role;scaffold;Shapes;Signal Transduction;spatiotemporal;structural imaging;Structure;Testing;Tissues;uptake

PROJECT_TITLE: Mitochondrial Calcium Uniporter in Signaling and Dynamics

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Substance Misuse

PI_NAMEs: WU, SAMUEL S (contact)

PROJECT_TERMS: Acceleration;Address;Adherence;Affect;Alcohol consumption;alcohol use disorder;Alcohols;Behavioral;Behavioral Sciences;Biological;biomedical ontology;Caring;Clinical;Clinical Research;Clinical Trials Design;co-infection;community engagement;comorbidity;Data;Data Analyses;data centers;Data Collection;data integration;data management;Data Management Resources;data privacy;data quality;Data Science;Data Science Core;data sharing;Data Sources;data standards;Databases;design;Development;Disparate;effective intervention;Electronic Health Record;emerging adult;Ensure;Epidemiology;Equation;experience;Florida;Goals;Health;health data;health determinants;Health Services Research;Healthcare;HIV;improved;Infection;Informatics;Information Dissemination;Infrastructure;innovation;Intervention;Knowledge Discovery;Machine Learning;machine learning algorithm;Measures;Mental Health;Mentors;Methodology;Methods;Modeling;Monitor;Morbidity - disease rate;mortality;Natural Language Processing;online repository;Ontology;Outcome;Persons;Pilot Projects;Policy Research;power analysis;Predisposition;Preparation;Procedures;Program Research Project Grants;programs;protocol development;Protocols documentation;Qualifying;Quality Control;Randomized;recruit;Research;research data dissemination;Research Design;Research Methodology;Research Personnel;Research Project Grants;research study;Resources;Sample Size;Scheme;secondary analysis;Self Management;Sexually Transmitted Diseases;Site;social determinants;social health determinants;Source;Statistical Data Interpretation;Statistical Models;substance use;Technology;tool;Training;transmission process;Trust;Universities;webinar

PROJECT_TITLE: SHARE Data Science Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices we make influence what, and how, we remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes, and the skills gained will prepare me to become an independent investigator in this field.

PI_NAMEs: QASIM, SALMAN EHTESHAM (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: addiction;Address;Affect;Automobile Driving;Behavior;Behavioral;Biological;Biological Assay;Biological Markers;Brain;Cognition;Complex;computational basis;Computer Models;Decision Making;Disparate;Electrodes;Electrophysiology (science);Epilepsy;Event;Exhibits;frontal lobe;Functional disorder;Functional Magnetic Resonance Imaging;Goals;healthy volunteer;Hippocampus;Hour;Human;human subject;Image;Impairment;Intractable Epilepsy;Knowledge;Learning;Link;Measures;Medial;Mediating;member;Memory;memory consolidation;Memory Loss;memory process;memory recognition;Mental Depression;Mental disorders;Mentors;Mentorship;Midbrain structure;Modeling;Monitor;multidisciplinary;neural;Neurobiology;neuromechanism;Neurons;neurophysiology;Outcome;Parahippocampal Gyrus;Patients;Performance;Phase;Play;Predisposition;Process;Psychological reinforcement;recruit;Research;Research Personnel;Reversal Learning;reward processing;Rewards;rumination;Seizures;Signal Transduction;skills;Sleep;Stimulus;Study models;Techniques;temporal measurement;Testing;theories;time interval;Training

PROJECT_TITLE: The computational and neural mechanisms linking decision-making and memory in humans


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Underage Drinking

PHR: The SHARE program will develop, test and implement behavioral interventions to improve alcohol use and viral load in youth living with HIV in Florida. At the foundation is a a community engagement core in a state-wide diversity initiative to maximize public health impact.

PI_NAMEs: ENNIS, NICOLE  (contact)

PROJECT_TERMS: Address;Adolescent;Adolescent Medicine Trials Network;Adoption;Advertisements;AIDS prevention;Alcohol consumption;alcohol prevention;Alcohols;Behavior Therapy;Behavioral Sciences;Characteristics;Clinical Sciences;Collaborations;Communication;Communities;community engaged research;community engagement;cost effective;COVID-19 pandemic;Data Collection;Data Science Core;design;electronic consent;emerging adult;Ensure;Equity;experience;Florida;Foundations;Funding;Gays;Goals;Guidelines;Health;HIV;implementation facilitation;implementation science;improved;Individual;Informed Consent;innovation;interest;Intervention;Measurement;Measures;Monitor;Outcome;Participant;participant retention;Patient Recruitments;Perception;Persons;Police;Policy Maker;Population;Populations at Risk;pre-clinical;preventive intervention;Procedures;Process;Process Assessment;programs;Protocols documentation;Provider;Public Health;recruit;Research;Research Personnel;Resources;scale up;Self Management;Sexual Health;Site;social media;Solid;success;Testing;tool;translational pipeline;Translational Research;United States National Institutes of Health;Viral Load result;virtual;web portal;web site;Work;young adult;Youth

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Precision Medicine;Prevention;Prostate Cancer;Urologic Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE Prostate cancer is the second most common cancer diagnosed in males worldwide, and a significant cause of morbidity and mortality. At this time, there is a significant unmet need for identifying men at initial diagnosis who will develop more aggressive disease possibly leading to symptoms, metastases, or death. This project proposes the combination of clinically established prognostic biomarkers and radiomic signatures extracted from magnetic resonance imaging of the prostate gland, co-registered with diffusion basis spectrum imaging (DBSI), and matrix- assisted laser desorption ionization (MALDI) imaging, to optimally select candidates for active surveillance from males being assessed at initial diagnosis.

PI_NAMEs: LUNA CASTANEDA, JOSE MARCIO (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Affect;Algorithms;anti-cancer research;Applied Research;Award;Biological Markers;Biopsy;Biopsy Specimen;cancer cell;cancer diagnosis;Cancer Patient;Cancer Prognosis;candidate selection;career;Career Transition Award;cell type;Cellular Structures;Cessation of life;Clinical;clinical decision-making;clinical imaging;clinical investigation;curative treatments;Data;Data Science;Derivation procedure;Diagnosis;diagnostic biomarker;Diffusion;Disease;early detection biomarkers;Ecosystem;Extracellular Matrix;Extracellular Matrix Proteins;genomic signature;Gleason Grade for Prostate Cancer;Goals;histological slides;Image;Imaging Techniques;Immune system;improved;Inflammatory;innovation;Link;Location;Magnetic Resonance Imaging;male;Malignant neoplasm of prostate;Malignant Neoplasms;mass spectrometric imaging;men;Methods;Molecular;molecular imaging;Monitor;Morbidity - disease rate;mortality;Neoplasm Metastasis;novel diagnostics;overtreatment;Patient Selection;patient stratification;Patients;Pattern;Performance;Polysaccharides;Population Surveillance;Positioning Attribute;Prediction of Response to Therapy;predictive marker;predictive signature;Prognosis;prognostic;prognostic assays;Prognostic Marker;prospective;Prostate;prostate cancer progression;Prostate-Specific Antigen;Prostatectomy;Proteins;radiological imaging;radiomics;randomized trial;Recommendation;recruit;Research;Research Personnel;Resources;Retrospective cohort;Risk;Screening for Prostate Cancer;Specificity;Specimen;spectrograph;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Staging System;Students;Symptoms;synergism;System;Talents;Technology;Testing;therapeutic biomarker;Time;Training;translational medicine;tumor;tumor progression;Visualization;Work

PROJECT_TITLE: Prognostic Radiomic Signatures in Prostate Cancer Patients on Active Surveillance

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Telehealth;Underage Drinking

PROJECT_TERMS: adaptive intervention;Address;Adherence;Adolescent;Adolescent Medicine Trials Network;Age;Alcohol consumption;alcohol measurement;Alcohols;antiretroviral therapy;Behavior Therapy;Behavioral;Behavioral Sciences;Biological Markers;biological sex;brief alcohol intervention;checkup examination;Clinic;Clinical Trials;Cognitive;Communities;community organizations;comparative cost effectiveness;comparative effectiveness;compare effectiveness;Cost Effectiveness Analysis;Data;design;Development;Dose;Economic Factors;Effectiveness;effectiveness/implementation trial;Electronic Health Record;emerging adult;Ensure;Ethnic Origin;Evidence based program;Florida;follow-up;Gender;Goals;hazardous drinking;Health;health economics;HIV;Home;Hybrids;implementation facilitators;implementation/effectiveness;improved;innovation;Intervention;intervention delivery;intervention effect;Interview;Journals;marijuana use;medication compliance;Mental Depression;Mental Health;Methods;mHealth;mhealth interventions;Modeling;Motivation;motivational enhancement therapy;National Institute on Alcohol Abuse and Alcoholism;normative feedback;Outcome;outreach;peer;Persons;Prevention;primary outcome;Professional counselor;programs;Publishing;Randomized;recruit;Registries;Reporting;Research;Risk Behaviors;Sampling;satisfaction;scale up;Self Management;Sequential Multiple Assignment Randomized Trial;skills;social media;standard care;substance use;success;telehealth;therapy design;transgender;Translating;United States Substance Abuse and Mental Health Services Administration;Unsafe Sex;Viral Load result;web-based intervention;Youth

PROJECT_TITLE: SMARTer Healthy Choices: Optimizing a state-wide scalable intervention to improve alcohol and HIV self-management in adolescents and emerging adults (Project SUSTAIN)


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Telehealth;Underage Drinking

PI_NAMEs: WANG, YAN  (contact)

PROJECT_TERMS: Address;Adherence;Adolescent;Affect;Age;age group;aged;Alcohol consumption;alcohol intervention;Alcohols;Algorithms;Anxiety;Behavioral Research;Behavioral Sciences;Biological Markers;biological sex;Biosensor;Blood;Blood alcohol level measurement;Caring;Cellular Phone;Chronic Disease;Clinical Trials Design;Cognitive;comorbidity;Computer software;Consumption;Data;Detection;Development;Disease Management;Distal;drinking;Ecological momentary assessment;Elements;emerging adult;Ethnic Origin;Feedback;follow-up;Fostering;Foundations;Funding;Future;Gender Identity;Goals;Health;High Prevalence;HIV;HIV diagnosis;HIV Infections;Hour;improved;Informal Social Control;innovation;Intervention;Laboratories;Literature;machine learning algorithm;machine learning model;Medical;Mental Depression;Mental Health;mHealth;mhealth interventions;Modeling;Monitor;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Patient Self-Report;Pattern;Persons;Population;programs;Race;Randomized;randomized trial;Reporting;Research;Rewards;Self Management;sensor;sensor technology;Subgroup;Substance abuse problem;substance use;Symptoms;Testing;theories;Time;time use;tool;transmission process;Viral;wearable device;Work;Wrist;Youth

PROJECT_TITLE: A wrist biosensor-based mHealth suite to support alcohol intervention in young people living with HIV


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Substance Misuse;Underage Drinking

PI_NAMEs: NICHOLS, SHARON L (contact)

PROJECT_TERMS: Address;Age;Alcohol abuse;alcohol comorbidity;Alcohol consumption;Alcohols;Behavior;Behavioral;Behavioral Sciences;biological sex;Cannabis;Caring;Characteristics;childhood adversity;Chronic;cognitive function;Collaborations;Communities;community collaboration;community engagement;Complex;Critical Care;Cultural Characteristics;Decision Making;Development;diaries;Discrimination;Disease Management;Education;Electronics;emerging adult;emotion regulation;Emotions;Enrollment;Ensure;ethnic identity;ethnic minority;Ethnic Origin;experience;Failure;Gender;Gender Identity;Goals;hazardous drinking;Health;high risk;HIV;improved;Individual;Inequity;innovation;intersectionality;Intervention;knowledge of results;life span;Link;Longitudinal cohort study;marginalization;Measures;Mediating;member;Mental Health;Methods;microaggression;Minority;minority children;Modeling;Outcome;outreach;Participant;Pathway interactions;perceived stress;Persons;poor sleep;Population;Prevention;programs;Quality of life;Race;racial identity;racial minority;Regulation;Role;screening;Self Management;sexual identity;sexual minority;sexual minority stress;Sleep;Sleep Disorders;sleep health;social stigma;Source;Stress;stress management;stress symptom;substance use;success;Surveys;therapy development;tool;transgender;transmission process;Trauma;trauma exposure;traumatic stress;United States National Institutes of Health;Viral;Viral Load result;Vulnerable Populations;Youth

PROJECT_TITLE: Defining intervention targets along pathways from cumulative stress and trauma to alcohol and HIV self-management among young people living with HIV (Project DEFINE)


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Although messenger RNA (mRNA) as a therapeutic holds tremendous promise, bottlenecks to development, application, and manufacturing arise due to current enzyme-based production methods. Solid-phase synthesis of chemically defined mRNAs offers an ideal solution but also presents its own challenges, including compatibility with translation and mRNA synthesis size limits. To address these challenges and unlock a new generation of mRNA therapeutics, this project creates and studies solid- phase synthesized mRNAs with diverse chemical modifications and unnatural linkages.

PI_NAMEs: GAGNON, KEITH THOMAS (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Achievement;Address;Antisense Oligonucleotides;Azoles;Bacteria;Biochemical Reaction;Biological;Bypass;Cells;chemical synthesis;Chemicals;Chemistry;COVID-19 vaccine;design;Development;Disease;DNA;Double-Stranded RNA;drug development;Enzymes;FDA approved;Formulation;Gene Expression;gene replacement;gene therapy;Generations;Genetic;Genetic Diseases;Genetic Medicine;Half-Life;Heart;Human;immunogenic;In Vitro;in vivo;innovation;Length;Libraries;lipid nanoparticle;manufacture;Medicine;Messenger RNA;Methodology;Methods;Minor;Modality;Modeling;Modification;Molecular Biology;Mus;nuclease;nucleic acid-based therapeutics;Nucleic Acids;Nucleotides;Open Reading Frames;patient safety;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Plant Resins;Process;Production;Property;Proteins;Reporter;Research;Ribose;Ribosomes;RNA;RNA chemical synthesis;S phase;Safety;Science;Site;Small Interfering RNA;Solid;sugar;Technology;Testing;Therapeutic;therapeutic development;therapeutic protein;therapeutic RNA;Time;Tissues;Toxin;Translations;Vaccines;Vertebral column

PROJECT_TITLE: Toward synthetic chemically defined mRNA for human therapeutics

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Neurosciences;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: Narrative River blindness is a major neglected tropical disease caused by the filarial nematode Onchocerca volvulus with 21 million people estimated to be affected, 99% of whom live in sub-Saharan Africa. The main intervention strategy relies on annual or bi-annual mass drug administration (MDA) of ivermectin, however, in areas of high endemicity and intense transmission, elimination is unlikely to be achieved within reasonable time frameworks, if at all, using ivermectin MDA on its own. Alternative and complementary therapeutic strategies are urgently needed at this crucial point in the path from control to elimination. The long-term goal of this project is to overcome this barrier by rationally identifying, optimizing, and developing new drug candidates and novel integrated treatment regimens to complement current control interventions, and consequently enhance the probability and feasibility of eliminating this devastating disease which mainly affects the most marginalized populations of rural Africa. 2

PI_NAMEs: JANETKA, JAMES W;LUSTIGMAN, SARA ;MITREVA, MAKEDONKA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Adult;Affect;Affinity;Africa;Africa South of the Sahara;aged;alternative treatment;Animal Model;Area;Aspartic Endopeptidases;Autopsy;Biochemical;Biological Assay;Brugia;Brugia pahangi;Cells;Chemicals;clinical development;Combined Modality Therapy;Complement;Data;design;Development;Disease;drug candidate;Drug Design;Drug Kinetics;drug repurposing;Drug Targeting;Drug usage;Epidemiology;Female;Fertility;Filariasis;Fostering;Gerbils;global health;Goals;HIV;HIV Protease Inhibitors;Human;improved;in silico;In Vitro;in vivo;in vivo evaluation;Individual;inhibitor;innovation;Intervention;Intestinal Volvulus;Ivermectin;knock-down;Knowledge;Lead;lead optimization;Loa loa;Lopinavir;marginalized population;mathematical model;Modeling;Molecular Target;Motility;moxidectin;multidisciplinary;Mus;neglected tropical diseases;Nelfinavir;Nematoda;novel;novel therapeutics;Ocular Onchocerciasis;Onchocerca;Onchocerca volvulus;Onchocerciasis;Oral;Outcome;Parasites;Parents;Pathway interactions;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;preclinical study;Prevalence;prevent;Probability;programs;Property;prophylactic;Prophylactic treatment;Protease Inhibitor;Proteins;rational design;Recombinants;Regimen;Ritonavir;RNA Interference;Rodent;Rodent Model;Roentgen Rays;Rural Population;Series;Structure;Testing;Therapeutic;Time;timeline;tool;Toxic effect;transcriptomics;transmission process;Treatment Protocols;Validation;vector-borne;World Health Organization

PROJECT_TITLE: Innovative therapeutic strategies to support elimination of river blindness

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: Framingham

ORG_NAME: KEPHERA DIAGNOSTICS, LLC

ORG_STATE: MA

PHR: Narrative Lyme disease, a bacterial infection which has become the most common vector-borne disease in the United States, poses a diagnostic challenge to clinicians and a threat of chronic illness to patients. The current paradigm for diagnosis of Lyme disease relies on a two-step laboratory- based testing approach. In this Phase II proposal, we will complete the development of a simple and accurate one-step test for Lyme disease that can be carried out in an average, non- specialized laboratory, enabling faster diagnosis and consequently more appropriate treatment for patients, and we will validate its performance in a clinical study to support an FDA submission.

PI_NAMEs: LEVIN, ANDREW E. (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Accounting;Algorithms;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;antibody detection;Antigens;Area;assay development;Attention;Bacterial Antigens;Bacterial Infections;Binding;Biological Assay;Blood;Borrelia;Borrelia burgdorferi;Chronic Disease;Clinical;clinical diagnosis;Clinical Research;commercial launch;Communicable Diseases;cost;cross reactivity;Development;Diagnosis;Diagnostic;diagnostic assay;Diagnostic tests;Disease;Enzyme-Linked Immunosorbent Assay;Epitopes;erythema migrans;European Union;Evaluation;Exanthema;Eye;Formulation;Geography;Government;Grant;Growth;Hybrids;Immunochemistry;Immunoglobulin G;Immunoglobulin M;in-vitro diagnostics;Individual;Infection;Laboratories;Legitimacy;Location;Lyme Disease;Lyme disease diagnosis;manufacture;Marketing;Medical;Methodology;Methods;Midwestern United States;Nature;New England;novel;Order Spirochaetales;Patients;Peptides;Performance;Persons;Phase;Physicians;Predictive Value;Preparation;Procedures;Process;prospective;Proteins;Protocols documentation;prototype;Public Health;Reagent;Recombinant Proteins;Recommendation;Recording of previous events;Reproducibility;research clinical testing;Research Design;Rest;Risk;Risk Factors;Running;Sampling;screening;Screening Result;Sensitivity and Specificity;Serology;Serology test;Serum;Services;Site;Specificity;Step Tests;Symptoms;synthetic peptide;Test Result;Testing;Tick-Borne Diseases;Time;Translations;United States;Validation;Vector-transmitted infectious disease;Western Blotting

PROJECT_TITLE: Hybrid ELISA: Simple and specific one-tier assay for Lyme disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-E(13)]