NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: Although tremendous progress has been made in treatment modalities of acute myeloid leukemia (AML), there is the necessity to improve and develop novel therapeutic approaches. We propose to develop a strategy based on Gene Expression Analysis (GMA) profiling to identify patients with AML displaying specific preferences for repairing spontaneous and drug-induced DNA damage. DNA repair pathways will be then attacked by GMA-guided DNA repair inhibitors eventually combined with standard treatment to eliminate leukemia stem and progenitor cells without affecting normal cells and tissues.

PI_NAMEs: MAZIN, ALEXANDER V;SKORSKI, TOMASZ  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;Base Excision Repairs;BRCA deficient;brca gene;BRCA1 gene;BRCA2 gene;burden of illness;cancer cell;Cell Proliferation;Cells;Chromosome abnormality;comparative efficacy;Cytotoxic agent;Data;Defect;design;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA Repair Pathway;DNA replication fork;Dominant-Negative Mutation;Double Effect;Double Strand Break Repair;Down-Regulation;Drug Combinations;drug standard;Drug Targeting;drug-like compound;Gene Expression;Gene Expression Profiling;Gene Mutation;Generations;Genes;Genetic;Genetic Induction;Genotoxic Stress;genotoxicity;Goals;homologous recombination;improved;In Vitro;in vivo;Individual;individual patient;Induced Mutation;inhibitor;Knock-out;Knowledge;leukemia;leukemic stem cell;Malignant Neoplasms;Mediating;Modality;Mutate;Mutation;Mutation Analysis;Nonhomologous DNA End Joining;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Oxidative Stress;PALB2 gene;paralogous gene;Pathway interactions;Patients;Pattern;personalized medicine;Pharmaceutical Preparations;Play;Poly(ADP-ribose) Polymerase Inhibitor;preference;prevent;Proteins;RAD51C gene;RAD52 gene;Reactive Oxygen Species;recombinational repair;Regimen;repaired;Reporting;Role;standard care;stem cells;Structure-Activity Relationship;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;treatment response;XRCC2 gene;XRCC3 gene

PROJECT_TITLE: AML mutation-guided drugging of DNA repair

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Epilepsy;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: RIVERSIDE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms linking demyelination to neuronal hyperexcitability and neurodegeneration will increase understanding of the pathogenesis of numer- ous neurological disorders and diseases including multiple sclerosis, trauma, and stroke. The project is relevant to NIH's mission, as the research pursues fundamental knowledge of glial-neuronal interactions in the brain, and how they go awry in the context of demyelinating disease, which may provide a foundation for the develop- ment of novel and more effective strategies to treat neurological disorders by selectively targeting specific glial- neuronal interaction mechanisms.

PI_NAMEs: BINDER, DEVIN K;TIWARI-WOODRUFF, SEEMA K (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Abate;Ablation;Acceleration;Anatomy;aquaporin 4;Area;Astrocytes;Autopsy;Brain;brain tissue;Cells;Cessation of life;Chronic;chronic demyelination;Clinical Research;cognitive function;Connexins;Coupled;Coupling;Cuprizone;Data;Demyelinating Diseases;Demyelinations;Development;Diet;disability;Disease;Dyes;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;Foundations;Functional disorder;Gap Junctions;Generations;Gliosis;Glutamates;Goals;Hippocampus;Human;Human Pathology;human tissue;Immunohistochemistry;Impairment;in vivo;insight;Interneurons;Knowledge;Lesion;Leukocytes;Link;Location;Mediator;Metabolic;Metabolism;Mission;Molecular;Monitor;Morbidity - disease rate;Morphology;mouse model;multi-electrode arrays;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Nerve Degeneration;Nervous System Disorder;neuronal excitability;Neurons;neurotransmission;novel;Onset of illness;Outcome;Parvalbumins;Pathogenesis;patient population;patient subsets;Patients;Population;Predisposition;Prevention;Process;protein expression;Proteins;Public Health;Publishing;reconstruction;Relapse;Reporter;Research;Rest;Role;Seizures;Signal Transduction;spatiotemporal;Specificity;Specimen;Stroke;Techniques;Testing;Time;Transgenic Organisms;translational impact;translational study;Trauma;United States National Institutes of Health;Work

PROJECT_TITLE: Demyelination is coupled to neuronal hyperexcitability leading to seizures

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases;Women's Health Research

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: CORE B – ORGANOID BIOBANK PROJECT NARRATIVE Tractable experimental models that accurately recapitulate human pancreatic and breast carcinoma biology are critical to the overall goal of this Program Project Grant. Core B will provide all three Projects with access to a large human patient-derived organoid biobank, which includes hundreds of breast and pancreatic cancer samples. Expertise and methods for evaluating transcriptional and splicing dependencies will be provided to provide deep insights into biomarkers and molecular mechanisms.

PI_NAMEs: DOS SANTOS, CAMILA  (contact)

PROJECT_TERMS: 3-Dimensional;Antineoplastic Agents;biobank;Biological Assay;Biological Markers;Biological Models;Biology;biomarker identification;Breast;Breast Adenocarcinoma;Breast Carcinoma;Cancer Biology;Cancer cell line;Cancer Model;Carcinoma;Cell Line;Cell Lineage;Cellular Structures;Characteristics;Classification;Clinical;Collaborations;cost effective;Custom;Dependence;Development;Disease Progression;drug development;drug sensitivity;Ensure;Exhibits;Experimental Models;experimental study;Funding;Genes;Genetic;Genetic Transcription;genome annotation;genomic profiling;Genomics;Goals;Growth;Health;Health system;Human;human model;In Vitro;in vitro Model;in vivo;innovation;insight;Investigation;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Mammary Duct;Mammary gland;Mammary Neoplasms;Measurement;Mediating;member;Methodology;Methods;Microscopic;migration;Modeling;Molecular;Molecular Profiling;molecular subtypes;Morphology;mouse model;next generation;novel;Oncologist;Organ;Organoids;Pancreas;Pancreatic Adenocarcinoma;Pancreatic carcinoma;Pancreatic duct;pancreatic neoplasm;Pathologist;patient population;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;Pregnancy;Primary Neoplasm;Procedures;Productivity;Program Research Project Grants;programs;racial diversity;Reproducibility of Results;Research;Research Personnel;research study;Resources;response;RNA Splicing;Sampling;self organization;Services;Specimen;spheroids;stem;stem cells;Study models;Surgeon;Surrogate Markers;Technology;Testing;Therapeutic;therapeutic evaluation;Tissues;Traction;Training;transcriptome;transcriptomic profiling;transcriptomics;Treatment Efficacy;tumor;tumor microenvironment;Tumor Subtype;Validation;Variant

PROJECT_TITLE: Core B: Organoid Biobank


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Disruption of mitochondrial dynamics and quality control are key components of leading causes of disability, such as cerebrovascular disease and age-related neurodegeneration. The proposed research aims to investigate the contributions of dysfunctional mitochondrial quality control to cerebral ischemia/reperfusion injury, as well as the onset and progression of neurodegenerative disease. Utilizing innovate molecular and computational techniques, these studies will advance our understanding of mitochondrial dysfunction and inform the development of future therapeutics.

PI_NAMEs: FOGO, GARRETT MCGUIRE (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: active control;Affect;age related;age related changes;age related neurodegeneration;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease related dementia;analysis pipeline;Architecture;Bioenergetics;Biogenesis;biological adaptation to stress;Biology;Blood flow;Brain;Cause of Death;Cell Death;Cells;Cerebral Ischemia;cerebrovascular;Cerebrovascular Disorders;Characteristics;Classification;Complex;Computational Technique;Computer Models;computerized tools;conditional knockout;cost;deprivation;Development;disability;Disease;Elements;energy efficiency;Ensure;Event;experimental study;Exposure to;Functional disorder;Future;Glucose;Homeostasis;Image;Imaging Device;Impaired cognition;in silico;In Vitro;in vitro Model;Individual;Injury;innovation;Investigation;Investments;Ischemia;Knock-out;live cell imaging;Machine Learning;Mammalian Cell;Mediating;Metabolic dysfunction;Methods;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;Molecular;Morphology;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Nervous System Trauma;Neurodegenerative Disorders;neurological pathology;Neurons;normal aging;novel;Nutrient;oxidation;Oxidative Stress;Oxygen;Parkinson Disease;Pathologic;Pathology;Pattern;Phase;Phenotype;Physiological;Postdoctoral Fellow;pre-doctoral;preservation;Process;Production;Protein Dynamics;Proteomics;proteostasis;Quality Control;real-time images;Reperfusion Injury;Reperfusion Therapy;Reporter;Reporter Genes;Reproducibility;Research;Respiration;Risk Factors;Role;simulation;skill acquisition;Swelling;Synapses;System;Technical Expertise;Technology;temporal measurement;Testing;Therapeutic;Therapeutic Intervention;Time;timeline;tool;Transgenic Organisms;United States;Work

PROJECT_TITLE: Exploring the mechanisms of dysfunctional mitochondrial quality control in cerebrovascular disease and the aging brain


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Some Latino subgroups are at greater risk of heart disease than others based on years in the US, generations in US, and country of origin. Prior large-scale studies assessing these risks have treated this racially diverse population as monolith, failing to capture the variety racial characteristics that can affect how Latino subgroups develop heart disease. We propose to improve how we measure and identify racial subgroups within Latino populations to better understand differences in heart disease risk, permitting specific, targeted solutions for racial health inequities.

PI_NAMEs: WALLACE, DESHIRA DAMILKA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accent;Acculturation;Address;Adult;Affect;Asian;Behavior;Behavioral;Belief;Biological Factors;Biological Markers;Biological Sciences;Black race;Boston;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;career development;Censuses;Cessation of life;Characteristics;Chronic;Classification;Cohort Studies;Complement;cost estimate;Country;Data;Data Collection;design;Development;Development Plans;Diet;Dimensions;Discrimination;disease disparity;Disease Progression;Disparity;Disparity population;Doctor of Philosophy;Education;Employment;epidemiologic data;epidemiology study;Equation;Ethnic Origin;Ethnic Population;Evolution;experience;Factor Analysis;Faculty;Focus Groups;Generations;Glucose;Goals;Growth;Health;health difference;health inequalities;heart disease risk;Heart Diseases;Hypertension;improved;Income;Individual;Inequity;interest;intersectionality;Intervention;Interview;K-Series Research Career Programs;Language;Latino;Latino Population;longitudinal analysis;marginalization;Measurement;Measures;Mentors;Methods;Minority Groups;Modeling;multi-racial;National Heart, Lung, and Blood Institute;Non-Insulin-Dependent Diabetes Mellitus;North Carolina;novel;Obesity;Outcome;Pattern;Perception;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Prevention strategy;Process;protective factors;Psychosocial Factor;Psychosocial Stress;Public Health;Puerto Rican;Qualitative Methods;Race;racial difference;racial diversity;racial population;Religion;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Proposals;research study;Resources;Risk Assessment;Risk Factors;skills;Skin;skin color;social epidemiology;social exclusion;social factors;Social Sciences;Sociology;Stigmatization;Stratification;Stress;Subgroup;Surveys;Techniques;theories;Time;Training;treatment strategy;United States;United States National Institutes of Health;Universities;Woman;Writing

PROJECT_TITLE: Racialization and Cardiovascular Risk Factors among Latinos - An Intersectional Approach


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome;Wound Healing and Care

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed research is relevant to the mission of the NIH because a better understanding of the mechanisms by which immune responses to commensal microbes will contribute to treatment of inflammatory, immune- mediated and autoimmune disorders. The proposed work is of particular relevance to host defense and wound repair, and to immune-mediated diseases such as atopic dermatitis.

PI_NAMEs: HARRISON, OLIVER JAMES (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Acceleration;Adaptive Immune System;antimicrobial;Atopic Dermatitis;Attention;Autoimmune Diseases;biological adaptation to stress;Body Surface;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Chronic;commensal microbes;Communication;Containment;Cues;Cutaneous;cytokine;Data;Development;Disease;Distal;Epithelial Cells;Family member;GATA3 gene;Gene Expression Profile;genetic manipulation;Goals;Grant;Health;Homeostasis;Host Defense;Human;Hybrids;IL17 gene;IL18 gene;IL1R1 gene;Immune;Immune response;Immune system;Immunity;in vivo;Infection;Infection prevention;Infectious Skin Diseases;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;injury and repair;innate immune function;Innate Immune System;innovation;insight;Interleukin-13;Interleukin-5;keratinocyte;Mediating;Memory;Messenger RNA;microbial;microbiota;MicroRNAs;Mission;Modeling;Molecular Target;mouse model;Mus;mutualism;novel;novel therapeutic intervention;pathogen;pathogenic microbe;Pathology;Pathway interactions;Peptide/MHC Complex;pharmacologic;Physiology;Play;Population;Post-Transcriptional Regulation;PPBP gene;Production;Property;Protein Binding Domain;Proteins;Psoriasis;Reagent;Regulatory Element;repaired;Reporter;Research;resident commensals;response;RNA-Binding Proteins;Role;Sentinel;Signal Pathway;Skin;skin barrier;Skin colonization;Skin injury;Skin Tissue;skin wound;Staphylococcus epidermidis;stem;T cell response;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;tissue injury;tissue repair;Tissues;tool;transcriptome;Transgenic Mice;Translating;Translations;United States National Institutes of Health;Untranslated Regions;Work;wound healing;Wound Infection

PROJECT_TITLE: Commensal-specific T cell function in skin wound repair

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Behavioral and Social Science;Burden of Illness;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Rare Diseases;Tobacco;Tobacco Smoke and Health

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PI_NAMEs: GUERRA, CARMEN E. (contact)

PROJECT_TERMS: Abbreviations;Acceleration;acronyms;Address;Affect;Alcohol consumption;Area;Aromatic Polycyclic Hydrocarbons;Behavioral Risk Factor Surveillance System;Black race;Breast;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;carcinogenicity;Catchment Area;chimeric antigen receptor T cells;Clinical and Translational Science Awards;Clinical Trials;Colorectal Cancer;Communication;Communities;community advisory board;community center;community engaged research;community engagement;community engagement process;Community Outreach;County;Data;Death Rate;Dedications;Delaware;design;detection method;Disparity;disparity reduction;Electronic Health Record;Ensure;environmental carcinogenesis;Environmental Hazards;Evaluation;evidence base;Evidence based intervention;Evidence based treatment;experience;Family;Foundations;Funding;Funding Mechanisms;Future;General Population;Geography;Goals;Guidelines;Health;health management;Health system;HIV/AIDS;Human Papilloma Virus Vaccination;Human Papillomavirus;Impact evaluation;improved;Incidence;Investments;Leadership;Liver;Logic;Lung;Malignant mesothelioma;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;medically underserved;Melanoma;member;Minority Participation;Mission;Modeling;mortality;New Jersey;Non-Hodgkin's Lymphoma;Obesity;Outcome;Output;outreach;patient oriented;Pediatric Hospitals;Pennsylvania;Perception;Personal Satisfaction;Persons;Philadelphia;Policies;Population;Population Sciences;prevent;Process;programs;Prostate;Provider;Public Health;Reporting;Research;Research Project Grants;residence;Resources;Risk Factors;Scientist;Screening for cancer;severe mental illness;Shapes;Signal Recognition Particle;skills;Smoking;success;Superfund;Sushi Domain;tobacco carcinogenesis;Tobacco use;tool;treatment services;Universities;Update;uptake;Work

PROJECT_TITLE: Community Outreach and Engagement

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative This project investigates mechanisms underlying endowed protective effect of astrocytic protein Peroxiredoxin 6 against Aβ pathology, and expedience of upregulating Peroxiredoxin 6 expression as a therapeutic approach for Alzheimer’s disease. It also explores how astrocytes guide microglia to counter Aβ accumulation in the brain.

PI_NAMEs: SADOWSKI, MARTIN JOSEPH (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Abbreviations;abeta accumulation;abeta deposition;AD transgenic mice;Affect;Alleles;alveolar epithelium;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid beta-Protein;Animals;APP-PS1;Applications Grants;Astrocytes;Attenuated;Behavioral;beta amyloid pathology;Brain;Breeding;cell injury;Cell Lineage;Cognitive deficits;Containment;Data;Defense Mechanisms;Deposition;Diffuse;Disease;Dose;Endothelial Cells;Endothelium;Endowment;Enzymes;Epithelial Cells;Experimental Models;Genes;genetic risk factor;glutathione peroxidase;Impaired cognition;Individual;Inflammatory Response;Knock-in;Knock-out;Knockout Mice;Macrophage;Membrane Lipids;Microglia;Molecular;mouse model;Mus;Mutant Strains Mice;Nerve Degeneration;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuropathology;novel;Outcome Measure;overexpression;Pathway interactions;Penetration;peroxiredoxin;Phagocytes;Phase;Phenotype;Phospholipase;Phospholipid Metabolism;Play;Point Mutation;pre-clinical;prevent;Process;protective effect;Proteins;Proteomics;proteostasis;receptor;repaired;response;Role;Senile Plaques;Severities;Signal Pathway;Signal Transduction;Site;Synapses;Testing;Therapeutic;transcriptomics;Transgenes;Transgenic Mice;Transgenic Organisms;TREM2 gene;Up-Regulation;Variant;Work

PROJECT_TITLE: Mechanisms of Peroxiredoxin 6 Endowed Protection in Alzheimer’s Disease


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Lung cancer is the leading cause of cancer deaths in the USA, with an estimated 158,000 deaths in 2016: the direct cause of these deaths is the eventual emergence of resistance to initially effective therapies, which is a process driven by Darwinian evolution. To better understand, and prevent the emergence of this resistance, we propose an integrated mathematical and experimental research project focused on discovering and targeting the ecological and evolutionary mechanisms driving resistance in EGFR mutated non-small cell lung cancer. Our overarching goal is find evolutionarily informed treatment strategies using existing drugs to extend the survival of patients with this disease.

PI_NAMEs: SCOTT, JACOB GARDINIER (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: anti-cancer research;Area;Automobile Driving;Biological Assay;Biology;cancer cell;Cancer Etiology;cancer type;Cause of Death;Cell Line;Cessation of life;Clinic;Clinical;clinical application;clinical development;Clinical Oncology;clinically relevant;Computer Models;Coupled;Data;Dependence;design;Directed Molecular Evolution;Disease;Drug Design;drug discovery;Drug resistance;drug sensitivity;Ecology;effective therapy;Environment;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Equation;Evolution;experience;Experimental Designs;experimental study;Family;Fibroblasts;Game Theory;Goals;improved;in vivo;Individual;innovation;insight;Investigation;Knowledge;Laboratories;Learning;Libraries;life history;Malignant neoplasm of lung;Malignant Neoplasms;Maps;mathematical model;Mathematics;Measures;Modeling;Molecular;Molecular Profiling;multidisciplinary;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel strategies;novel therapeutics;objective response rate;Oncology;Outcome;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Play;Population;pressure;prevent;Process;Protocols documentation;Publications;replicator;Research;Research Project Grants;Resistance;resistance mechanism;Secondary to;Shapes;Solid Neoplasm;targeted agent;targeted treatment;Techniques;Testing;Therapeutic;Time;time use;Toxic effect;Translating;Translations;treatment strategy;tumor;tumor heterogeneity;tumor progression;Tyrosine Kinase Inhibitor

PROJECT_TITLE: Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung Cancer

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


PHR: CORE C - ANIMAL MODELING AND IMAGING PROJECT NARRATIVE Animal modeling and imaging is a mainstay of modern cancer research. Core C is at the leading edge of technology development and implementation of imaging in animal models of cancer. The Core is committed to continuing its innovations with impacts on both the Program and the broader scientific community.

PI_NAMEs: LYONS, SCOTT KEITH (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;Agreement;Animal Cancer Model;Animal Experiments;animal imaging;Animal Model;animal model selection;animal tissue;Animals;anti-cancer research;Antibodies;Antisense Oligonucleotides;Automobile Driving;Biological Models;bioluminescence imaging;cancer cell;Cancer cell line;cancer imaging;Cancer Model;Cells;cohort;Collaborations;Collection;Communities;cost;cost effective;Data;Data Set;design;Development;Dissociation;Doctor of Philosophy;Employment;Engraftment;Ensure;Equipment;Evaluation;experience;experimental study;Funding;Genetic;Genetic Transcription;Goals;Harvest;high resolution imaging;Histopathology;Image;imaging approach;imaging modality;imaging software;imaging system;Imaging technology;Immune;immunodeficiency;Immunohistochemistry;In Situ Hybridization;in vivo;in vivo imaging;Individual;Injections;innovation;innovative technologies;insight;Investigation;Kinetics;Label;Leadership;Location;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;member;Methods;Microscope;Modernization;Modification;Molecular;molecular imaging;molecular marker;mouse model;Mouse Strains;Nature;Neoplasm Metastasis;novel;novel imaging technology;Organoids;Pancreas;pancreatic cancer model;Pathologic;Pathologist;pharmacologic;Positron-Emission Tomography;programs;reconstruction;Reporter;Research Personnel;Resolution;RNA Splicing;Sampling;Scanning;Services;Signal Pathway;Signal Transduction;single photon emission computed tomography;Structure;System;Technology;technology development;technology validation;Time;tissue fixing;Tissue Sample;Tissues;tool;Training;transplant model;Transplantation;treatment response;tumor;Tumor Burden;tumor diagnosis;tumor growth;tumor heterogeneity;tumor progression;Tumor Tissue;ultrasound;United States National Institutes of Health;Work;X Inactivation;X-Ray Computed Tomography

PROJECT_TITLE: Core C: Animal Modeling and Imaging


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LITTLE ROCK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PUBLIC HEALTH RELEVANCE  Marshallese are a subpopulation of Pacific Islanders that are experiencing significant health disparities, with some of the highest documented rates of type 2 diabetes mellitus (T2DM) in the world. Culturally- appropriate diabetes self-management education and support (DSMES) has been shown effective in other minority communities; however, no DSMES has been shown effective and sustainable with Marshallese in the Republic of the Marshall Islands. It is critically important to determine a DSMES intervention that is effective, scalable, and sustainable in this population experiencing extreme health disparities and a crisis in rates of T2DM.

PI_NAMEs: RIKLON, SHELDON  (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Acquired Blindness;Address;Adherence;Affect;Arkansas;arm;Behavior;behavior change;Behavioral;Blood Pressure;Body mass index;Cardiometabolic Disease;cardiometabolic risk;Certification;Communities;community based participatory research;Community Health Aides;community organizations;comparison group;compliance behavior;Complications of Diabetes Mellitus;cultural values;culturally appropriate intervention;Data;diabetes educator;Diabetes Mellitus;diabetes self-management;Disparity;Distress;Education;Educational Curriculum;effectiveness evaluation;effectiveness testing;Eligibility Determination;empowerment;Evaluation;experience;Faith-based organization;Family;family influence;Family member;family support;Fasting;fasting glucose;Free Association;Funding;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care service;health disparity;Health Expenditures;Healthcare;heart disease risk;improved;Indigenous;innovation;Intervention;Kidney Failure;Knowledge;Life Expectancy;limb amputation;Lipids;Lower Extremity;Marshall Islands;Measures;medication compliance;minority communities;Modeling;motivational enhancement therapy;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Pacific Islander;Pacific Islands;Participant;patient engagement;Patient-Focused Outcomes;Patients;Periodicity;Persons;Physicians;Population;post intervention;Prevalence;primary outcome;process improvement;public health relevance;Quality of life;Randomized;Research;Resources;Risk Factors;Self Efficacy;Self Management;Services;treatment group;United States;United States National Institutes of Health;waist circumference;Waiting Lists;Work

PROJECT_TITLE: Evaluation of the effectiveness of Ajjmuurur Baamḷe DSMES in the RMI

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Genetics;Muscular Dystrophy;Myotonic Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Myotonic Dystrophy type 1 is a complex disease characterized by CNS dysfunction. Patients with the severe congenital DM1 (CDM1) are intellectually challenged. There is no cure for CNS dysfunction in DM1. We propose to apply new mouse model to determine the cause of CNS dysfunction in CDM1. The development of drug for the reduction of CNS pathology in CDM1 will be performed in mouse model of CDM1. The obtained knowledge will be used for the developing clinical trial for pediatric patients with CDM1.

PI_NAMEs: TIMCHENKO, LUBOV T (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Affect;Aftercare;Age;Age Months;Anxiety;biopharmaceutical industry;Brain;CDK4 gene;Central Nervous System;Clinical Research;Clinical Trials;cognitive function;Complex;Congenital Myotonic Dystrophy;CUG repeat;cyclin D3;Defect;Development;disability;Disease;drug candidate;drug development;Event;Family;Functional disorder;Genes;Growth;Heart;Human;improved;inhibitor;Knock-in;Knowledge;Long-Term Effects;Messenger RNA;Modeling;Molecular;Motor;mouse model;mRNA Translation;Mus;Muscle;Muscle Fibers;mutant;Mutate;Myoblasts;Myotonic dystrophy type 1;Nervous System Physiology;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;pediatric patients;Phase;Phenotype;Phosphorylation;Phosphotransferases;postnatal;prenatal;Proteins;RNA metabolism;RNA Splicing;RNA-Binding Proteins;Role;Severities;Signal Pathway;Site;Skeletal Muscle;Stress;stress granule;Survival Rate;System;Testing;Therapeutic;Therapeutic Effect;Tissues;transcriptome;Translations;Work

PROJECT_TITLE: CNS in Congenital DM1: Pathogenesis and Therapeutic Opportunities

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: AUGUSTA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Cognitive impairment, and specifically Alzheimer’s disease, represents one of the most significant healthcare problems in the aging population of the United States, and development of effective therapy will be facilitated by understanding its underlying mechanisms. We are studying a protein called synaptobrevin1/VAMP1 and present strong argument for the association of VAMP1 to Alzheimer’s disease, which has public health relevance. After completion of the proposed research we will have developed a new model that offer insight into the mechanism and potential treatment of Alzheimer’s disease leading to dementia in the elderly, thus the proposed research is aligned with the mission of NIH that pertains to developing fundamental knowledge that will help reduce the burdens of human disability.

PI_NAMEs: DEAK, FERENC  (contact)

PROJECT_TERMS: Abeta synthesis;Acceleration;Action Potentials;Affect;Age;age group;age related changes;Aging;aging population;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;amyloid formation;amyloid precursor protein processing;amyloidogenesis;Brain;C-terminal;Cell Physiology;Chromosomes;Cognition;Communication;Complex;Couples;Coupling;Data;Dementia;Development;Diagnosis;disability;Disease;Disease Progression;effective therapy;Elderly;Electrodes;Electrophysiology (science);Elements;Endocytosis;Endocytosis Pathway;Etiology;Exocytosis;experimental study;Fluorescence Microscopy;Functional disorder;Generations;Genes;Genetic;Genetic Screening;Goals;Healthcare;Heterozygote;Hippocampus;Human;Human Amyloid Precursor Protein;Human Genetics;human old age (65+);Impaired cognition;in vivo;innovation;insight;Knockout Mice;Knowledge;Laboratories;Late Onset Alzheimer Disease;Learning;Link;member;Membrane Proteins;Memory;Methods;Mission;Modeling;Molecular;molecular targeted therapies;mouse model;Mus;mutant;Mutation;Nerve Degeneration;Neurons;neurotransmission;Neurotransmitters;novel;null mutation;older patient;overexpression;patch clamp;Pathologic;Pathway interactions;Pharmaceutical Preparations;Phase;Predisposition;preservation;prevent;Production;protective effect;Protein Isoforms;Proteins;public health relevance;receptor;Reporting;Research;Risk Reduction;Role;Sampling;Senile Plaques;Series;Severities;Single Nucleotide Polymorphism;SNAP receptor;Societies;Source;structural determinants;Synapses;synaptic failure;synaptic function;Synaptic plasticity;Synaptic Transmission;Synaptic Vesicles;System;Testing;Tg2576;Transgenic Mice;United States;United States National Institutes of Health;VAMP-1;Variant;Vesicle;vesicle-associated membrane protein;vesicular release

PROJECT_TITLE: Role of VAMP1 in synaptic transmission and Alzheimer's dementia

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


PHR: CORE D - NEXT-GEN SEQUENCING AND BIOINFORMATICS PROJECT NARRATIVE Genomics and Bioinformatics are essential tools in cancer research. Core D provides services in high-throughput sequencing and bioinformatic analysis to identify changes in transcription, splicing, and chromatin that drive the growth and maintenance of cancer. Bioinformatic tools will be continuously developed by this Core to support the evolving needs of the Projects.

PI_NAMEs: KOO, PETER K (contact)

PROJECT_TERMS: Address;Algorithms;anti-cancer research;Area;Awareness;base;biobank;Bioinformatics;bioinformatics tool;Biological Sciences;bisulfite sequencing;cancer cell;Cancer Center at Cold Spring Harbor Laboratory;cancer genome;Cells;ChIP-seq;Chromatin;chromatin isolation by RNA purification sequencing;Cleavage Under Targets and Release Using Nuclease;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collection;Communities;Complementary DNA;Computer software;cost;Data;Data Set;Databases;Detection;Development;Devices;DNA;DNA sequencing;DNA Sequencing Facility;exome;exome sequencing;Experimental Designs;Fostering;Funding;fusion gene;Galaxy;Generations;Genes;Genetic Screening;Genetic Transcription;Genome;genome sequencing;Genomics;Goals;Growth;High-Throughput Nucleotide Sequencing;Individual;innovation;instrument;Investigation;Investments;Link;Maintenance;Malignant Neoplasms;Maps;Mediating;member;Methods;Methylation;Mission;Modification;nanopore;next generation sequencing;novel;novel sequencing technology;Nucleotides;Organoids;Pattern;Performance;posttranscriptional;programs;Protein Isoforms;Publications;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;RNA;RNA Sequences;RNA Splicing;RNA-Binding Proteins;Running;sequencing platform;Services;single cell sequencing;single-cell RNA sequencing;Software Tools;Statistical Methods;targeted sequencing;Technology;technology development;Testing;Time;tool;transcriptome;transcriptome sequencing;Untranslated RNA;web site;whole genome;Work

PROJECT_TITLE: Core D: Next-Gen Sequencing and Bioinformatics


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Sleep Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Sleep and circadian disorders are extremely common and impact all aspects of public health. There is a need for new investigators to study sleep and circadian rhythm biology and examine their impact on cardiovascular, metabolic, pulmonary and neurodegenerative disease and overall quality of life. The goal of this joint training program with experienced faculty from Icahn School of Medicine at Mount Sinai and New York University Grossman School of Medicine is to provide mentored post-doctoral training in sleep and circadian science encompassing basic science and clinical research.

PI_NAMEs: AYAPPA, INDU A (contact);VARGA, ANDREW W

PROGRAM_OFFICER_NAME: BAIZER, LAWRENCE

PROJECT_TITLE: Multidisciplinary Research Training in Sleep Science

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Lung;Lung Cancer;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

PI_NAMEs: DOMCHEK, SUSAN M (contact)

PROJECT_TERMS: Abbreviations;acronyms;Area;Award;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer prevention;Cells;Clinical;Clinical Trials;community advisory board;community engagement;Community Outreach;Development;Diagnosis;Direct Costs;Discipline;environmental carcinogenesis;Faculty;Faculty Recruitment;Fostering;Funding;Goals;Grant;imaging program;Immunobiology;innovation;Intervention;Journals;lung cancer screening;Malignant Neoplasms;Manuscripts;Medicine;member;Nature;Oncology;Outcome;Paper;Pediatric Hospitals;Pediatric Oncology;peer;Peer Review;Performance;Philadelphia;Pilot Projects;Population Sciences;Process;programs;Publications;Radiobiology;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Scientist;Services;Strategic Planning;Talents;tobacco carcinogenesis;Translational Research;tumor;tumor metabolism;Update;Work

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative Glioblastoma (GBM) is the most common primary brain tumor in adults and one of the most deadly cancers, with a median patient survival of 12-15 months. This application aims to unravel the molecular mechanisms activating lipid synthesis in GBM by glutamine metabolism, and further reveal the novel and important role of SREBP-1 in upregulating glutamine uptake that promotes GBM growth. Completion of this study will significantly advance our knowledge of metabolism reprogramming in GBM and malignancies, also provide insights into potential therapeutic approaches for GBM treatment.

PI_NAMEs: GUO, DELIANG  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: 18F-Glutamine;Adult;Affect;Affinity;alpha ketoglutarate;amino acid metabolism;Amino Acid Transporter;Ammonia;Binding;Binding Sites;Biology;Brain;cancer cell;Cells;Cholesterol;Clinical;Data;Dissociation;Endoplasmic Reticulum;Enzymes;Essential Amino Acids;Exhibits;Genes;Genetic Transcription;Glioblastoma;Glucose;Glutamates;Glutaminase;Glutamine;glycosylation;Golgi Apparatus;Growth;improved;In Vitro;in vivo;insight;Insulin;Isoleucine;Knowledge;Laboratories;Leucine;Link;lipid biosynthesis;lipid metabolism;Lipids;Malignant Neoplasms;Measures;Mediating;Membrane;Metabolic;Metabolism;Modeling;Molecular;Mutate;N-terminal;Normal Cell;novel;Outcome;Pathway interactions;Patients;Play;Positron-Emission Tomography;prevent;Primary Brain Neoplasms;Process;Prognosis;programs;promoter;Promoter Regions;Protein Conformation;Proteins;Proteolysis;Publishing;rapid growth;Reporting;Repression;Role;Sampling;SCAP protein;Site;SRE-1 binding protein;synergism;Therapeutic;trafficking;transcription factor;tumor growth;Tumor Promotion;Tumor Tissue;uptake;Valine;Withdrawal;Xenograft Model

PROJECT_TITLE: Identifying SREBP-1 activation mechanism in glioblastoma and its new role in regulating glutamine metabolism

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ORG_CITY: HERSHEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative PARP10 is poorly characterized human enzyme. In this application, we propose to investigate the molecular mechanisms underlying the potential oncogenic function of PARP10. This would result in validation of a new target for cancer therapy.

PI_NAMEs: NICOLAE, CLAUDIA M (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Adenosine Diphosphate Ribose;ADP Ribose Transferases;Apoptosis;Biochemical;Biological;Biological Assay;brca gene;Breast;Bypass;cancer cell;carcinogenesis;Cell Cycle Progression;Cell Line;cell motility;Cell Physiology;Cell Proliferation;Cells;Cellular biology;Chromosome Fragile Sites;Clinic;Coupled;CRISPR/Cas technology;design;DNA Biochemistry;DNA biosynthesis;DNA fiber assay;DNA lesion;DNA Repair;DNA replication fork;DNA sequencing;DNA Structure;DNA-Directed DNA Polymerase;Down-Regulation;Enzymes;Epithelium;Exposure to;Family;Genes;genetic manipulation;Genetic Models;Genetic Transcription;genome editing;Genome Stability;Genomic DNA;Genomic Instability;genomic tools;Genomics;Growth;Hela Cells;Human;Immunocompromised Host;In Vitro;in vivo;inhibitor;Knock-out;Malignant Neoplasms;Measures;Mediating;member;Mitochondria;Modeling;Molecular;mouse genetics;mouse model;Mus;Mutagenesis;mutant;Mutation;next generation;next generation sequencing;Normal Cell;novel;Nucleic Acids;Oncogenes;Oncogenic;Ovarian;overexpression;oxidation;Pathway interactions;personalized cancer therapy;Phenotype;Poly(ADP-ribose) Polymerases;Polymerase;Post-Translational Protein Processing;Process;Proliferating;Property;Proteins;recruit;replication stress;Resistance;Role;S phase;Signal Transduction;Structure;targeted cancer therapy;Testing;transcriptome sequencing;transcriptomics;Transgenic Mice;tumor;tumor growth;Tumor Promotion;tumor xenograft;tumorigenesis;Ubiquitination;Validation

PROJECT_TITLE: The role of PARP10 in alleviating replication stress and promoting cellular proliferation and tumorigenesis

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative It is estimated that ~1/59 children are affected with Autism Spectrum Disorder (ASD), one of the most serious psychiatric disorders of childhood, defined by deficits in social communication and restricted interests/repetitive behaviors. Recent advances in functional brain imaging show promise that pre-diagnostic neural signatures for ASD may provide useful risk markers and may even be sensitive to responses to interventional therapies that have been shown to improve quality of life. In this R01 proposal, we will extend high density diffuse optical tomography methods, which can silently image brain function in a naturalistic setting and have the potential to be useful for pre-symptomatic risk monitoring, for an innovative and prospective longitudinal study of awake and engaged infants and toddlers at risk for developing ASD.

PI_NAMEs: EGGEBRECHT, ADAM THOMAS (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Age Months;age related;Algorithms;Anatomy;Auditory;autism spectrum disorder;autistic;awake;Award;Basic Science;Behavior;Behavior assessment;behavior measurement;Behavior Therapy;Behavioral;Behavioral Assay;behavioral impairment;Behavioral Symptoms;biobehavior;Biological;Brain;brain behavior;Brain imaging;Brain Mapping;case control;Categories;Child;Childhood;Claustrophobias;Clinical;Clinical Research;Clip;Cognitive deficits;cohort;cost;Data;Data Set;density;Development;Diagnosis;Diagnostic;diffuse optical tomography;Dimensions;Disparate;early childhood;Early Diagnosis;Early Intervention;Educational Intervention;Environment;ergonomics;Eye;flexibility;Functional Magnetic Resonance Imaging;functional near infrared spectroscopy;Future;gaze;General Population;Genetic;Goals;Head;Heritability;Image;Impairment;improved;improved outcome;individual variation;Infant;Infant Development;innovation;interest;Intervention;Language;Language Delays;Learning;Life;Light;Linear Regressions;Linguistics;longitudinal, prospective study;Loudness;Magnetic Resonance Imaging;male;Maps;Measures;Mental disorders;Methodology;Methods;Mission;Modality;Modeling;Modified Checklist for Autism in Toddlers;Monitor;Morphologic artifacts;Motion;Motor;movie;National Institute of Mental Health;neural;Neurocognitive;Neurodevelopmental Disorder;neuroimaging;Noise;novel;optical imaging;Optics;Parents;Participant;Pathway interactions;patient subsets;Phenotype;Predisposition;Prevention;Prognosis;programs;prospective;Psychopathology;Quality of life;Questionnaires;Recovery;repetitive behavior;Reporting;Research;Research Personnel;response;Risk;Risk Marker;Sampling;Scanning;Science;Scientist;Series;social;social communication;social skills;Software Tools;Supination;Surface;Techniques;Technology;Temperament;Testing;Therapeutic Intervention;Toddler;treatment strategy;United States;Visit;Visual;visual tracking;wearable device

PROJECT_TITLE: Illuminating development of infant and toddler brainfunction with DOT


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE By rigorously dissecting how the autophagy pathway suppresses metastatic outgrowth and pro-metastatic differentiation programs, this project will provide unique fundamental and timely insight into how to most effectively modulate autophagy to treat cancer patients, an issue of immense therapeutic significance.

PI_NAMEs: DEBNATH, JAYANTA  (contact)

PROGRAM_OFFICER_NAME: HILDESHEIM, JEFFREY

PROJECT_TERMS: Ablation;Adaptor Signaling Protein;Adhesions;Aftercare;Anti-malarials;Attenuated;Autophagocytosis;Autophagosome;Behavior;Biological;BRCA1 gene;Breast Cancer Model;cancer cell;cancer clinical trial;Cancer Patient;cancer recurrence;Cells;Complex;Cytokeratin-14 Staining Method;Cytoplasm;Data;Desmosomes;Distant;Distant Metastasis;Epithelium;Excision;Exhibits;Gene Expression;Genes;Genetic;Genetic Induction;Genetic Models for Cancer;Homeostasis;Human;Hydroxychloroquine;Impairment;in vivo;inhibition of autophagy;inhibitor;insight;interest;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Mammary Neoplasms;Mediating;metabolic fitness;Metastatic Neoplasm to the Lung;Metastatic/Recurrent;Methods;Modeling;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;Oncogenic;Pathway interactions;Patient-Focused Outcomes;Pattern;pharmacologic;Phenotype;Play;prevent;Primary Neoplasm;Process;programs;Proteins;Publishing;receptor;Recurrence;Recurrent tumor;Recycling;Regulation;Relapse;Residual Neoplasm;Role;Signal Transduction;single-cell RNA sequencing;Site;Stress;Therapeutic;therapy resistant;transcription factor;treatment response;tumor;Tumor Expansion;tumor growth;tumor heterogeneity;tumor initiation;tumor progression;Tumor Promotion;Up-Regulation

PROJECT_TITLE: Autophagy and Pro-metastatic Differentiation


NIH_SPENDING_CATS: Cancer

PI_NAMEs: SIMON, M. CELESTE (contact)

PROJECT_TERMS: Abbreviations;Acceleration;acronyms;animal imaging;Animals;Annual Reports;anti-cancer research;Applications Grants;Basic Science;biobank;Bioinformatics;biomedical informatics;Biomedical Research;Biometry;Biostatistics Core;Budgets;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer imaging;Cell Separation;Cells;Clinical Sciences;Clinical Trials;community engagement;Community Outreach;Comparative Pathology;Core Facility;cost effective;cost effectiveness;cost efficient;Data Mart;design;Electronics;Ensure;environment related cancer;environmental carcinogenesis;Equipment;Evaluation;Extramural Activities;Feedback;Flow Cytometry;Funding;Future;Genomics;Growth;Human;imaging facilities;imaging program;Immunology;improved;innovation;Institution;instrumentation;Laboratories;Leadership;Letters;Management Information Systems;medical schools;Medicine;meetings;member;metabolomics;Monitor;Mus;Oncology;Paper;Pathology;Pediatric Hospitals;Pennsylvania;Phenotype;Philadelphia;Policies;Population Sciences;Process;Process Assessment;Production;Productivity;programs;Protocols documentation;Publications;Radiation;Radiobiology;Research;Research Activity;Resource Sharing;Resources;response;Risk Factors;Services;Strategic Planning;Surveys;Sushi Domain;System;Technical Expertise;Technology;tobacco carcinogenesis;Training;Training and Education;Transgenic Organisms;translational medicine;Translational Research;tumor;Universities;Vaccines;Veterinary Medicine;Veterinary Schools;Work

PROJECT_TITLE: Shared Resource Management


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative. Altered serotonin signaling is linked to brain disorders such as depression and schizophrenia, but the vast complexity of the human brain makes it difficult to study this relationship. This study analyzes an excitatory signal modulated by serotonin within a model neural circuit that regulates a simple behavior in C. elegans. This work will advance our knowledge of serotonin signaling with the goal of better understanding its connection to mental disorders to enable strategies for developing more effective treatments.

PI_NAMEs: PRASHAD, SHAVANIE  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 3-Dimensional;Acetylcholine;Animals;Behavior;Behavioral;Biological Models;Brain;Brain Diseases;Caenorhabditis elegans;Calcium;calcium indicator;Cells;Chemical Synapse;Connexins;Data;Defect;Dense Core Vesicle;effective therapy;egg;Electrical Synapse;Electrons;Event;experimental study;Fluorescence Microscopy;Functional disorder;Gap Junctions;gene function;Genes;Genetic;Goals;Green Fluorescent Proteins;Human;Image;Induced Neurons;knock-down;Knowledge;Label;Light;Link;Measures;Mediating;Mental Depression;Mental disorders;Methods;Muscle;Muscle Cells;Muscle Contraction;Nematoda;neural;neural circuit;neural model;Neurons;Neuropeptides;neuropsychiatric disorder;neurotransmission;Neurotransmitters;optogenetics;Organism;Play;postsynaptic;presynaptic;prevent;protein biomarkers;Proteins;ratiometric;red fluorescent protein;Reporting;Research Personnel;response;RNA Interference;Role;Schizophrenia;sensor;Series;Serotonin;Signal Transduction;Source;Structure;Study models;Synapses;Synaptic Vesicles;System;Testing;tool;Varicosity;Vesicle;vesicle-associated membrane protein;Work

PROJECT_TITLE: Analysis of the signals modulated by serotonin in a C. elegans neural circuit

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03B-L(20)]


NIH_SPENDING_CATS: Autoimmune Disease;Genetics;Infectious Diseases;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project Narrative The proposed research is highly relevant to the NIH mission and public health because it will help define why Children with Primary Immunodeficiency Disease due to mutations in the NCKAP1L gene encoding Hem-1 fail to respond to immunizations and exhibit high mortality associated with bacterial and viral infections.

PI_NAMEs: IRITANI, BRIAN M (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Actins;Affect;Antibody Formation;Antibody Response;Antibody-mediated protection;Antigens;Autoantibodies;Autoimmunity;autoreactivity;B-Cell Activation;B-Cell Antigen Receptor;B-Cell Development;B-cell receptor repertoire sequencing;B-Lymphocytes;Bacteremia;Bacterial Infections;Biological Models;Bone Marrow;Cell Physiology;cell type;Cells;Characteristics;chemokine;Child;ChIP-seq;Cleavage Under Targets and Release Using Nuclease;Color;Communities;Complex;congenital immunodeficiency;Cre-LoxP;CRISPR/Cas technology;cytokine;Cytokine Receptors;Development;Diffusion;Disease;Exhibits;Family;Flow Cytometry;fly;Gene Expression;Gene Targeting;Genes;Genetic Heterogeneity;genetic regulatory protein;Genetic Transcription;genome wide association study;Goals;Guanosine Triphosphate Phosphohydrolases;Hematopoietic;Homeostasis;Homing;Homologous Protein;Human;human disease;human model;humanized mouse;Humoral Immunities;humoral immunity deficiency;Image;Immune;Immune Tolerance;Immunity;Immunization;immunodeficiency;Immunoglobulin Class Switching;Immunologic Receptors;Impairment;improved;Individual;Infection;Infectious Skin Diseases;Inflammatory Bowel Diseases;Influenza A virus;innovation;Integrins;Knowledge;Ligation;Link;loss of function;loss of function mutation;Lymphoid;Malignant lymphoid neoplasm;Mediating;member;Microscopy;migration;Mission;Modeling;Molecular;mortality;mouse model;Mus;Mutation;novel therapeutics;pathogen;Patients;Plasma Cells;Pneumococcal Pneumonia;Point Mutation;polymerization;Polymers;Predisposition;premature;Production;Prognosis;Proteins;Public Health;Receptor Signaling;Recurrence;Research;Resolution;respiratory pathogen;Respiratory Tract Infections;response;rho;Role;Signal Transduction;stem cells;Streptococcus pneumoniae;System;T-Cell Receptor;T-Independent Antigens;T-Lymphocyte;Technology;Testing;Time;Toll-like receptors;transcriptome;transcriptome sequencing;translational impact;two-photon;United States National Institutes of Health;Untranslated RNA;vaccination strategy;Variant;Virus Diseases

PROJECT_TITLE: WAVE Regulatory Complex in Primary Immunodeficiency Disease and autoimmunity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(52)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BALTIMORE

ORG_DEPT: BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The genetic variation underlying human phenotypic differences including disease is often discovered by mapping associations between sample genotypes and phenotypes. These studies have historically focused on individuals of European ancestries in part to mitigate statistical challenges that arise from inclusion of diverse samples, but the results of these studies are not necessarily applicable to individuals from other global populations. To extend these studies to diverse cohorts, this proposal aims to develop a novel method for controlling for population structure in association studies, and to apply this method to investigate sources of phenotypic variation in a large, globally diverse human gene expression dataset that our group recently generated.

PI_NAMEs: TAYLOR, DYLAN JAMES (contact)

PROGRAM_OFFICER_NAME: COLLEY, HEATHER

PROJECT_TERMS: Accounting;Address;Admixture;Affect;Automobile Driving;Awareness;Binding Sites;Biological;causal variant;cohort;Complex;Data;Data Set;data structure;differential expression;Disease;diverse data;epigenomics;Equity;Ethnic Origin;European;European ancestry;Event;Evolution;gene discovery;Gene Expression;Gene Expression Profile;gene expression variation;Gene Frequency;Genealogy;Genetic Enhancer Element;Genetic Recombination;Genetic study;genetic variant;Genetic Variation;Genome;Genomics;Genotype;Goals;Graph;Health;health care disparity;Human;Human Genetics;Human Genome;human RNA sequencing;improved;Individual;Knowledge;Length;Link;Linkage Disequilibrium;lymphoblastoid cell line;Maps;Measures;Methods;Modeling;Molecular;novel;Participant;Pattern;Phenotype;Phylogenetic Analysis;Population;Population Control;Population Genetics;Quantitative Trait Loci;Research;Research Design;Resolution;Resources;RNA Splicing;Sampling;Series;Site;Societies;Source;Stratification;Structure;Tissues;tool;trait;transcriptome sequencing;Trees;Underrepresented Populations;Variant;variant of interest;Work

PROJECT_TITLE: Uncovering sources of human gene expression variation in a globally diverse cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative: Using airway epithelial cells from well characterized and genotyped children with asthma we will determine if dysregulated interferon responses to rhinovirus infection by asthmatic airway epithelial cells are associated with exacerbation frequency, lung function, and/or T2-high vs. T2-low inflammation. We will pair human cell ex vivo approaches to work using a novel mouse model of human rhinovirus infection to provide in vivo mechanistic insights. These studies will allow us to identify potential novel therapeutic pathways to target in asthma.

PI_NAMEs: DEBLEY, JASON S (contact);ZIEGLER, STEVEN F

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Adrenal Cortex Hormones;Adult;Affect;airway epithelium;airway inflammation;airway remodeling;Alleles;Apoptosis;Asthma;asthma exacerbation;asthmatic;asthmatic airway;Biological Products;Cells;Characteristics;Child;Clinical;cohort;cytokine;Data;effective therapy;Emergency department visit;Epithelial Cells;Epithelium;experimental study;Frequencies;functional decline;gain of function;Gene Expression;Genes;Genetic;Genetic Polymorphism;genomic locus;Genotype;Heterogeneity;Hospitalization;Human;human model;humanized mouse;IFIH1;in vivo;in vivo evaluation;Incidence;Infection;Inflammasome;Inflammation;Inhalation;insight;Interferon Type II;Interferons;Interleukin-1 beta;Kinetics;Knock-out;Longitudinal Studies;Minor;Modeling;mouse model;Mouse Strains;Natural History;neutrophil;novel;novel therapeutics;Pathway interactions;Patients;Prevalence;Production;Proteins;pulmonary function;pulmonary function decline;Quantitative Trait Loci;Reporting;Respiratory Syncytial Virus Infections;response;Rhinovirus;Rhinovirus infection;Risk;Role;Schools;sensor;System;Testing;Time;TNF gene;TNFSF10 gene;transcriptomics;TSLP gene;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Dysregulated asthmatic epithelial interferon responses to viruses drive exacerbation, T2 inflammation, and airway remodeling

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE We have identified a robust copy number variant (CNV) signature that distinguishes homologous recombination deficient (HRD) pancreatic ductal adenocarcinomas (PDA). Our expertise in DNA content flow cytometry of solid tumors and the genomics of PDA, and Mayo Clinic resources will be leveraged to establish a novel CNV scoring assay (HRD-IA) for predicting treatment responses for patients with PDA. We will validate our assay for use with routinely collected formalin fixed paraffin embedded (FFPE) PDA tissues and will include CLIA approved protocols that will introduce our HRD-IA assay into routine clinical application.

PI_NAMEs: BORAD, MITESH  (contact)

PROGRAM_OFFICER_NAME: BHARTI, SANITA

PROJECT_TERMS: Acceleration;Address;American;Aneuploidy;Base Excision Repairs;Biological Assay;Biological Models;Biopsy;brca gene;BRCA mutations;BRCA1 gene;BRCA2 gene;Calibration;cancer cell;Cancer Etiology;cancer genome;Cells;Cellularity;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Chromosome abnormality;CLIA certified;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;clinically relevant;Complex;Copy Number Polymorphism;detection assay;Development;Diagnosis;Disease;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Inhibition;Environment;Flow Cytometry;Formalin;Freezing;Genome;genome analysis;genomic aberrations;Genomic Instability;genomic signature;Genomics;Genotype;homologous recombination;homologous recombination deficiency;improved;interstitial;Lesion;Malignant Neoplasms;Measures;Mediating;Mediator;Methods;Molecular;Morphology;Nature;Necrosis;neoplastic;neoplastic cell;novel;PALB2 gene;Pancreatic Ductal Adenocarcinoma;Paraffin Embedding;Pathogenicity;patient biomarkers;patient response;Patients;personalized medicine;Phase;Phenotype;Ploidies;Poly(ADP-ribose) Polymerase Inhibitor;Population;Prediction of Response to Therapy;predictive signature;predictive test;Procedures;prospective;Protocols documentation;Publishing;Quality Control;Research;Resistance;Resources;response;Sampling;Series;Solid Neoplasm;Sorting;standard of care;synthetic lethal interaction;targeted agent;targeted treatment;Tissue Embedding;Tissues;triple-negative invasive breast carcinoma;tumor;Variant;whole genome;Work

PROJECT_TITLE: HRD-IA signatures in pancreatic ductal adenocarcinoma


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: VONDERHEIDE, ROBERT H (contact)

PROJECT_TERMS: Abbreviations;Academy;acronyms;Address;anti-cancer research;Appointment;Area;aspirate;Basic Science;Behavioral Research;Big Data;biobank;Bioinformatics;biomedical informatics;biomedical scientist;Biometry;Cancer Burden;Cancer Center;Cancer Center Support Grant;Cancer Control;Catchment Area;Clinic;Clinical;Clinical Informatics;Clinical Research;Clinical Sciences;clinical translation;Collaborations;Communities;community advisory board;community engagement;Community Outreach;Creativeness;Decision Making;Development;Discipline;Ensure;Environment;environmental carcinogenesis;Equilibrium;Evaluation;experience;Feedback;Fostering;Funding;Future;Goals;Growth;Growth and Development function;Guidelines;Health Professional;imaging program;immune health;improved;Individual;Infrastructure;Institution;Investigational Therapies;Investments;Laboratories;Leadership;Malignant Neoplasms;medical schools;Medicine;meetings;member;Mission;Monitor;operation;Operations Research;Pediatric Hospitals;personalized diagnostics;Philadelphia;Policies;Population Sciences;precision oncology;Process;Productivity;Program Reviews;programs;Radiobiology;Recommendation;recruit;Reporting;Research;Resource Allocation;Resource Sharing;Resources;Risk Assessment;Role;Science;Scientific Advances and Accomplishments;Series;Strategic Planning;Surveys;Sushi Domain;Time;tobacco carcinogenesis;tool;Training;Training and Education;translational pipeline;Translations;Update;Vision

PROJECT_TITLE: Leadership, Planning and Evaluation


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Heart Disease;Heart Disease - Coronary Heart Disease;Mental Health;Neurosciences;Prevention

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Chronic psychosocial stress exposure is a potent but largely under-recognized risk factor for cardiovascular disease (CVD), and research shows that stress reduction techniques may have a benefit in individuals with CVD; however, the underlying mechanism linking stress to CVD remains uncertain. Cutting-edge brain imaging techniques have demonstrated changes in brain center activity in the setting of chronic stress. This multi- parametric hybrid PET/MRI study tests the hypothesis that stress reduction reduces stress-associated neurobiological activity as well as systemic and arterial inflammation and seeks to yield insights into mechanisms that translate stress into physical disease with the goal of improving our ability to prevent and treat CVD.

PI_NAMEs: OSBORNE, MICHAEL THOMAS (contact)

PROJECT_TERMS: Address;American Heart Association;Amygdaloid structure;Animals;Atherosclerosis;Award;Biological;biological adaptation to stress;Biological Markers;Biology;Biometry;Bone Marrow;Brain;Brain imaging;Brain region;Cardiac rehabilitation;Cardiology;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;career;Chronic;Chronic stress;Clinical;clinical trial implementation;Coronary Arteriosclerosis;Coronary heart disease;Data;Development;Disease;Drug Targeting;effective therapy;Engineering;Enrollment;Environment;Epidemic;Epidemiology;Event;Exclusion;fluorodeoxyglucose positron emission tomography;follow-up;Fostering;Foundations;Functional Magnetic Resonance Imaging;Funding;General Hospitals;Goals;Human;Hybrids;hypothalamic-pituitary-adrenal axis;Image;imaging modality;imaging study;Imaging Techniques;improved;improved outcome;Individual;Inflammation;Inflammatory;Inflammatory Response;insight;Institution;instructor;Interdisciplinary Study;Intervention;Investments;Knowledge;Lead;Leukopoiesis;Link;Magnetic Resonance Imaging;Massachusetts;Measures;Medical;medical schools;Medicine;Meditation;Mental disorders;Mentorship;Metabolic;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness-based stress reduction;Modification;Nervous System Disorder;neural;Neurobiology;neuroimaging;novel;Participant;Pathway interactions;Patients;Physiology;Positron-Emission Tomography;prevent;programs;Psychiatry;Psychosocial Stress;Publications;Qualifying;Radiology Specialty;Randomized;randomized trial;Randomized, Controlled Trials;Recording of previous events;Rehabilitation therapy;Reproducibility;Research;Research Personnel;Research Support;Resources;response;Role;skills;Stress;stress management;stress reduction;Sympathetic Nervous System;Symptoms;System;systemic inflammatory response;Techniques;Testing;Time;Tissues;Training;Translating;treatment as usual;United States National Institutes of Health;vascular inflammation;Work;X-Ray Computed Tomography

PROJECT_TITLE: The Effect of Mindfulness on Vascular Inflammation in Stable Coronary Disease: A Multi-System PET/MRI Study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Urinary incontinence (leaking) affects more than 18 million U.S. women and is associated with high costs and significant negative impact on quality of life. Effective non-surgical treatments are available but often do not reach patients. Urinary incontinence may be reduced by helping primary care practices to screen for incontinence and connect patients to resources that are already available within the community.

PI_NAMEs: BROWN, HEIDI WENDELL;FLYNN, KATHRYN E;NEUNER, JOAN MARIE (contact)

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Bridging Community-based Continence Promotion and Primary Care


NIH_SPENDING_CATS: Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: LEXINGTON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE. There are near 290,000 people in the United States of America that have a spinal cord injury (SCI) (with at least 18,000 new cases each year) many with functional impairment. The main objective of this grant proposal is to investigate a novel therapeutic strategy which modifies the inflammatory response and can potentially lead to protection of the spinal cord after injury, as well as functional recovery. This dose-response experimental approach will be studied in multiple injury levels and functional outcomes, as well as tracked over time and collectively, these studies will lead to better understanding of the impact of inflammatory modification after injury and can potentially lead to improvement in human care and outcomes.

PI_NAMEs: ALILAIN, WARREN JOSEPH;GENSEL, JOHN C (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Affect;American;Animal Model;Animals;Anti-Inflammatory Agents;Applications Grants;arm;Autonomic Dysreflexia;axonal sprouting;Basic Science;Biodistribution;Biological Assay;Bone Marrow;Breathing;Caring;Cell Death;Cells;central pattern generator;Cervical;Cervical spinal cord injury;Cervical spinal cord structure;Chronic;Clinical;Clinical Trials;clinically relevant;Contusions;Data;Dichloromethylene Diphosphonate;Distal;Dose;efficacy evaluation;Encapsulated;Esthesia;FDA approved;Flow Cytometry;Forelimb;Frustration;Functional impairment;functional outcomes;Funding;Goals;Grant;Hand functions;Hindlimb;Hour;Human;Immune;Immune Targeting;Immunologic Deficiency Syndromes;Impairment;improved;improved outcome;indexing;Individual;Infiltration;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Laboratories;Lesion;Leukocytes;Liposomes;Liver;Locomotion;Locomotor Recovery;Macrophage;Mediating;meeting reports;meetings;Minocycline;Modeling;Modification;monocyte;Motor;Multiple Trauma;Myelopoiesis;Neuroglia;neuroprotection;novel therapeutic intervention;Organ;Outcome;Outcome Measure;Output;Pain;Pathology;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Population;pre-clinical;preclinical evaluation;Production;Publishing;Quality of life;Rattus;Recovery;Recovery of Function;recruit;Regulation;repaired;Reporting;Research;Research Personnel;Respiration;respiratory;response;Rodent;Rodent Model;Sensory;side effect;Site;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Spinal Cord Plasticity;Spinal Injuries;Spleen;Steroids;synaptogenesis;Testing;Therapeutic;Thoracic spinal cord structure;Time;tissue repair;Tissues;Toxic effect;Translating;translational impact;translational therapeutics;Translations;Treatment Efficacy;United States;United States National Institutes of Health;Voice

PROJECT_TITLE: Macrophage Depletion Therapy for Spinal Cord Injury


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE A major challenge facing contemporary genomic medicine is the clinical community’s desire for yes/no answers to the nuanced issue of whether a specific genetic variant will produce a meaningful phenotype. The current framework used to assess the significance of these variants classifies them from likely pathogenic/ pathogenic to likely benign/benign, with most stuck as variant of uncertain significance. We intend to prove that clinically meaningful knowledge is lost in this compression of variant information into a classification and that a data-driven estimate of disease penetrance is a higher resolution alternative.

PI_NAMEs: KRONCKE, BRETT M (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Address;All of Us Research Program;American;Arrhythmia;Autopsy;Bayesian Modeling;Benchmarking;Benign;biobank;Biological Assay;Cardiac;Cardiac Myocytes;Cell membrane;Cessation of life;Classification;Clinical;clinical phenotype;Code;Codon Nucleotides;cohort;Communities;cost;Coupled;Data;Data Collection;data standards;Diagnosis;Diagnostic tests;Disease;disease model;disorder prevention;drug withdrawal;Electrocardiogram;Electronic Medical Records and Genomics Network;Electrophysiology (science);Etiology;Event;exome;exome sequencing;Future;Generations;Genes;Genetic;genetic variant;Genome;genome sequencing;Genomic medicine;Genomics;Genotype;Heterozygote;heuristics;in silico;In Vitro;Incidence;Individual;Inherited;insight;interest;International;Ion Channel;Japan;Knowledge;Label;Life;Location;Long QT Syndrome;Medical;Medical Genetics;medical schools;Methods;Mutagenesis;novel;novel diagnostics;patch clamp;Pathogenesis;Pathogenicity;Patients;Penetrance;Performance;Pharmaceutical Preparations;Phenotype;Population;Postpartum Period;Potassium Channel;predictive modeling;Predictive Value;Probability;Procedures;prospective;protein structure;Proteome;Publishing;rare variant;Research Proposals;Resolution;Risk;Risk Assessment;risk stratification;risk variant;Role;segregation;sudden cardiac death;Sudden Death;Sudden infant death syndrome;Syndrome;System;Technology;Testing;trafficking;Training;Validation;Variant;variant of unknown significance;Vision;Woman

PROJECT_TITLE: Integrating KCNH2 Variant-Specific Features and Heterozygote Phenotypes to Estimate Long QT Penetrance

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention;Stroke;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative: Fibromuscular dysplasia (FMD) is an arterial disease that can cause stenosis (inward growth), aneurysm (outward growth), dissection (tearing), or tortuosity (abnormal bending) of blood vessels, leading to manifestations such as high blood pressure, stroke, heart attacks, and death. These dysplasia-associated arterial diseases are estimated to occur in 1-4% of the U.S. population and most often afflicts women. This study will use genetic and laboratory approaches to discover and characterize the involved genes and understand their functions in causing pathologic changes in the arterial wall, leading to the cardiovascular manifestations; the biologic insights from this study will be important for developing novel diagnostic and therapeutic strategies.

PI_NAMEs: GANESH, SANTHI K (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Alleles;Aneurysm;Arterial Disorder;arterial remodeling;Beds;biobank;Biological;Biological Factors;Biological Models;biological sex;Blood Vessels;Cardiovascular Manifestation;Cardiovascular system;Cell model;Cessation of life;Clinical;clinical diagnosis;Complex;Computer Analysis;Disease;disease diagnosis;Dissection;Dysplasia;experimental study;Extracellular Matrix;Fibromuscular Dysplasia;Genes;Genetic;genetic approach;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genomics;Goals;Growth;Heritability;Heterogeneity;Hypertension;in vitro Model;in vivo;insight;Laboratories;Medial;Modeling;Molecular;Molecular Genetics;Morbidity - disease rate;mortality;mouse model;Myocardial Infarction;novel diagnostics;novel therapeutic intervention;Outcome;Pathologic;Phenotype;Population;Precision Health;Predisposition;Prevention;Resolution;Resources;Role;Sex Differences;Smooth Muscle;Stenosis;Stroke;Susceptibility Gene;Testing;Variant;variant of unknown significance;Vascular Diseases;Vascular Smooth Muscle;Woman

PROJECT_TITLE: Genomic and Functional Studies of Dysplasia-Associated Arterial Diseases


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Schizophrenia;Serious Mental Illness

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE Despite its low prevalence, schizophrenia is one of the leading causes of disability worldwide. Immune processes are implicated in the etiology of schizophrenia but remain poorly understood, which is further complicated by the highly clinically heterogenous nature of the disorder. The proposed research will investigate the role of genetically regulated immune marker trajectories in clinical dimensions of schizophrenia to advance the field’s biological and clinical understanding of this devastating neuropsychiatric disorder.

PI_NAMEs: LAKE, ALLISON MICHELLE (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Age;All of Us Research Program;Antipsychotic Agents;Autoimmune Diseases;Behavior;biobank;Biological;Biological Markers;Blood;C-reactive protein;Chromosome 6;Clinical;clinical biomarkers;clinical heterogeneity;Code;cohort;Complement;Copy Number Polymorphism;cytokine;Data;Development;Diagnosis;Diagnostic;digital repositories;Dimensions;disability;Disease;Electronic Health Record;Etiology;first episode psychosis;Genes;Genetic;genetic epidemiology;genetic predictors;Genetic Risk;genetic risk factor;genome wide association study;genomic locus;Genotype;Heritability;Heterogeneity;Hospitalization;Immune;immune function;Immune system;Immunogenetics;Immunologic Epidemiology;Immunologic Factors;Immunologic Markers;indexing;Individual;Inflammation;Inflammatory;Informatics;inpatient psychiatric treatment;Inpatients;insight;Institution;Interleukin-6;Joints;Laboratories;Leukocytes;Link;Longitudinal cohort;Low Prevalence;Major Histocompatibility Complex;Measures;Mediating;Mediation;Mediator;Mendelian randomization;Mentors;Modeling;Nature;neuropsychiatric disorder;neuropsychiatry;Outcome;Pathogenesis;Pathway interactions;Patients;Pattern;Perceptual distortions;Peripheral;Population;predict clinical outcome;predictive marker;Process;programs;Proteins;psychiatric inpatient;repository;Research;Resources;Retrospective cohort study;Role;Sampling;Schizophrenia;schizophrenia risk;schizophrenia spectrum disorder;Signal Transduction;social;Structure;targeted treatment;Therapeutic Intervention;Time;treatment response;Veterans;whole genome;Withdrawal;Work

PROJECT_TITLE: Investigating the role of immune genes and inflammatory biomarkers in schizophrenia heterogeneity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


NIH_SPENDING_CATS: Aging;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PI_NAMEs: VOGL, DAN TOBY (contact)

PROJECT_TERMS: Abbreviations;acronyms;Address;Adult;Age;black patient;Black race;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer health disparity;cancer research center director;Catchment Area;Child;Childhood;Clinical Cancer Center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;community engagement;Community Outreach;Complex;Conduct Clinical Trials;Data;data integrity;data management;Discipline;Disease;Elderly;Elements;Enrollment;Ensure;Exclusion;expectation;experience;Focus Groups;Funding;Goals;Hispanic;Home;human old age (65+);human subject;Human Subject Research;improved;Individual;Infrastructure;innovation;Institutional Policy;Intervention;Intervention Trial;investigator-initiated trial;Investments;Lead;Leadership;Legal;life span;Malignant Childhood Neoplasm;Malignant Neoplasms;medical specialties;member;Minority;Minority Enrollment;Minority Groups;Monitor;Monitoring Clinical Trials;Nursing Research;oncology program;operation;Parents;participant enrollment;participant safety;Patient Participation;Patients;Pediatric Hospitals;Pediatric Oncology;Pediatric Research;Peer Review;Pennsylvania;pharmacovigilance;Philadelphia;Policies;Procedures;Protocols documentation;quality assurance;Regulation;Reporting;Research;research study;Review Committee;Safety;Services;Source;Study Subject;Supervision;System;Time;Training and Education;treatment trial;Underserved Population;Universities;Update;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Malaria Vaccine;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: The first malaria vaccine is being rolled out even though it has suboptimal efficacy for children living in malaria endemic areas. The focus of this proposal is to determine which combination of vaccine-elicited immune responses protect these children against malaria, in contrast to factors that result in malaria vaccine failures. This knowledge will help improve the next generation of malaria vaccines intended for children who bear the burden of this disease.

PI_NAMEs: MOORMANN, ANN M (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: 4 year old;Adult;Age;Anti-malarials;Antibodies;antibody-dependent cell cytotoxicity;Area;Biological Assay;booster vaccine;burden of illness;Cells;Cellular Immunity;Child;circumsporozoite protein;Clinical;cohort;Combined Vaccines;Computer Models;Country;design;Development;Dose;Epigenetic Process;Evaluation;Exposure to;Flow Cytometry;follow-up;Frequencies;functional group;Ghana;Human;Immune;Immune response;Immune system;Immunity;Immunization Programs;Immunoglobulin G;Immunology;improved;In Vitro;Individual;Infection;Invaded;Kenya;Knowledge;Link;Liver;Longitudinal cohort study;Longitudinal Studies;Machine Learning;Malaria;Malaria Vaccines;Malawi;Measurement;Measures;Modification;monocyte;next generation;Parasites;Performance;phase III trial;Phenotype;Plasmodium falciparum;programs;Prophylactic treatment;prospective;randomized effectiveness trial;Recombinant Proteins;Recommendation;Regimen;Research Design;Schedule;secondary analysis;Series;Serology;Sporozoites;System;systemic inflammatory response;T-Lymphocyte;Testing;Time;tool;Training;transcriptome sequencing;transmission process;Vaccinated;Vaccination;vaccination schedule;vaccine development;vaccine efficacy;vaccine failure;vaccine response;Vaccines;volunteer

PROJECT_TITLE: A systems immunology approach to evaluate malaria vaccine performance in endemic regions of Kenya


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative The recent push for early clinical diagnosis of ADRD at the time of symptom onset would be bolstered by evidence of better long-term health for diagnosed patients, more appropriate healthcare utilization, or decreased medical costs. The goal of this project is to develop the evidence base describing the predictors and consequences of underdiagnosis (i.e., late or missed diagnosis) vs early clinical diagnosis of dementia in healthcare settings. Based on our findings, healthcare consumers and medical providers will be able to make better informed choices about when to seek or offer cognitive evaluation, and public health agencies, health systems, and health insurers will be able to use our findings when deciding whether and how to promote ea rly evaluation and diagnosis of dementia.

PI_NAMEs: JAMES, BRYAN DAVID (contact);POWER, MELINDA C

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Advocacy;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Autopsy;Black race;Caring;Classification;Clinical;clinical diagnosis;clinical practice;Cognitive;cognitive testing;cohort;Communities;comorbidity;cost;cost comparison;Costs and Benefits;Data;Data Set;Dementia;dementia care;depressive symptoms;Diagnosis;diagnostic criteria;Disabilities experience;disability;Disease;Disparity in diagnosis;Early Diagnosis;Education;Emergency department visit;Enrollment;Ethnic Origin;Evaluation;evidence base;experience;falls;Family;frailty;Futility;Goals;Government;Health;health care service utilization;health care settings;Health Personnel;Health Policy;Health system;Healthcare;hospital readmission;Hospitalization;improved;Incentives;Insurance Carriers;Investments;Latino;Life;Link;Longitudinal cohort;male;Medical;Medical Care Costs;Medicare;Medicare claim;mortality;neuropathology;Nongovernmental Organizations;Nursing Homes;older adult;Older Population;Outcome;Participant;Pathologic;Patients;Perception;Personal Satisfaction;Persons;Provider;Public Health;Race;Records;Research;sex;Symptoms;System;Testing;Time;Visit

PROJECT_TITLE: Predictors and consequences of the timing and accuracy of clinical dementia diagnosis

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


PI_NAMEs: NASTA, SUNITA  (contact)

PROJECT_TERMS: Abbreviations;acronyms;Adult;Agreement;authority;Budgets;Businesses;Cancer Center;Cancer Center Support Grant;cancer research center director;Child;Childhood;Clinical Protocols;Clinical Research;Clinical Trials;Contracts;Data;data tools;Discipline;Disease;Electronics;Ensure;Funding;Goals;Guidelines;Human;human subject;improved;investigator-initiated trial;Malignant Childhood Neoplasm;Malignant Neoplasms;medical schools;Monitor;operation;Parents;Pediatric Hospitals;peer;Peer Review;Pennsylvania;phenomics;Philadelphia;Procedures;Protocols documentation;Reporting;Research;Research Priority;Review Committee;Safety;Science;System;Time;Universities

PROJECT_TITLE: Protocol Review and Monitoring System


ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Tumor heterogeneity is a well-known property of treatment resistant, recurrent, and metastatic breast cancer. The proposed research project is relevant to public health because it will provide a genetically tractable Cancer rainbow mouse model for inducing and visualizing tumor heterogeneity in an immune intact system. The proposed studies will credential the use of a novel Crainbow mouse model that more accurately recapitulates the heterogeneity found in treatment resistant HER2+ breast cancer patients. Our proposal will significantly improve upon the translational utility of mouse models for preclinical trials and at the same time provide a reliable tool for reconstructing the molecular and cellular interactome controlling tumor heterogeneity.

PI_NAMEs: SNYDER, JOSHUA CLAIR (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Animals;Bar Codes;Basic Science;Biological Models;Breast Cancer Model;Breast Cancer Patient;Carcinoma;Cells;Clinic;Clinical effectiveness;clinical predictors;Clonal Evolution;Clonality;Complex;Credentialing;Data;diagnostic assay;efficacy research;Epithelial Cells;Epithelium;ERBB2 gene;Evolution;fluorescence imaging;Future;gastrointestinal epithelium;Gene Modified;Genes;Genetic;Genetic Heterogeneity;Genetic Models;Growth;Heterogeneity;Human;human disease;Immune;Immune system;improved;Invaded;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary gland;Maps;Metastatic breast cancer;Modeling;Molecular;mouse model;multiplex diagnostics;Mus;Neoplasm Metastasis;novel;novel therapeutics;Oncogenes;Oncogenic;Outcome;Phenotype;Pre-Clinical Model;preclinical trial;premalignant;Property;Protein Isoforms;Protocols documentation;Public Health;Publishing;Recurrence;Reproducibility;Research Project Grants;Resistance;Resources;Somatic Mutation;Source;spectrograph;standard of care;Standardization;stem;Stromal Cells;System;Techniques;Testing;Therapeutic Uses;therapy resistant;Time;tool;transcriptomics;Translating;Translational Research;Treatment Efficacy;treatment response;tumor;Tumor Biology;Tumor Escape;tumor heterogeneity;tumor microenvironment;Variant;Visualization;Work

PROJECT_TITLE: Visualizing tumor heterogeneity in an immune intact and autochthonous mouse model of breast cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ADMINISTERING_IC: DE

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Nutrition;Pain Research;Temporomandibular Muscle/Joint Disorder (TMJD);Women's Health Research

ORG_CITY: CLEMSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative The proposed experiments utilize critical biomechanical information and approaches to understanding the temporomandibular joint (TMJ) and associated disc, which were determined by our previous study of pig TMJ. It extends that approach into human patients, and combines it with state of the art patient-specific craniofacial morphology combined with oral function biomechanics. This approach will test healthy males and females, in comparison with those who have TMJ dysfunction, to determine why females get TMJ dysfunction and disease 3-8 times more frequently than males.

PI_NAMEs: YAO, HAI  (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: 3-Dimensional;Affect;Biological;Biomechanics;Cadaver;Cell Death;Cell Density;Cell Differentiation process;Cell Proliferation;Cell Survival;Cells;Cellular Metabolic Process;clinic ready;Clinical;clinical translation;Complex;Computer Models;Confocal Microscopy;Consumption;craniofacial;cranium;Data;Dependence;Development;Diagnosis;Diffusion;Disease;Disproportionately impacts women;Elements;Energy Metabolism;Environment;Etiology;experience;experimental study;Family suidae;Female;Foundations;Freezing;Functional disorder;Future;Genetic;Glucose;Goals;Homeostasis;Human;human data;human tissue;In Situ;in vivo;Individual;Inflammation;Jaw;joint biomechanics;joint loading;Joints;Magnetic Resonance Imaging;male;Mandible;Measurement;Measures;mechanical load;Mechanics;men;Metabolic;metabolic rate;Metabolism;Methodology;Modeling;Morphology;Motion;Muscle;Nature;novel strategies;Nutrient;Nutrient availability;nutrition;Observational Study;Oral;oral behavior;Outcome;Oxygen;Pathway interactions;Patients;Pattern;Persons;Phase;Phenotype;porcine model;Production;Prognosis;Property;Research;Risk;Risk Factors;sex;Sex Differences;sex disparity;sexual dimorphism;Structure of articular disc of temporomandibular joint;Temporomandibular Joint;Temporomandibular Joint Disorders;Temporomandibular Joint Dysfunction Syndrome;Testing;Tissues;tool;Weight-Bearing state;Woman;women versus men;Work

PROJECT_TITLE: Integrating craniofacial morphology, oral function, temporomandibular biomechanics and mechanobiology to determine sex-specific TMJ pathophysiology in humans

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: GREENSBORO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF NORTH CAROLINA GREENSBORO

PHR: Project Narrative This project has clear public health implications, as it focuses on childhood obesity, a problem that has implications for long-term health and psychosocial functioning. Understanding the extent to which child self- regulation protects children with various risk factors from obesity risk in early childhood will inform the development and/or enhancement of targeted preventative intervention efforts.

PI_NAMEs: LEERKES, ESTHER M (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 11 year old;19 year old;2 year old;3 year old;5 year old;Address;Adolescence;Adult;Adverse effects;Advocate;Age;Appetitive Behavior;Applied Research;Basic Science;Behavior;Behavioral;Biological;biopsychosocial;Body mass index;Buffers;Characteristics;Child;Child Rearing;Childhood;Collaborations;Complex;cue reactivity;Data;Desire for food;Development;Dimensions;Discipline;early childhood;Eating;Economics;Emotional;Energy Metabolism;Environmental Risk Factor;Ethnic Origin;experience;feeding;follow-up;Food;Future;Health;Home;Home environment;Hormonal;Hormones;indexing;Individual;infancy;Infant;Inflammation;Influentials;Informal Social Control;innovation;Interdisciplinary Study;Intervention;Knowledge;Life;Life Style;Longitudinal Studies;Maternal Behavior;Measurement;Measures;Mental Health;Methodology;Methods;middle childhood;Modeling;Morbid Obesity;Mothers;multidisciplinary;National Institute of Child Health and Human Development;National Institute of Diabetes and Digestive and Kidney Diseases;Nursery Schools;Nutritional Science;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;obesity treatment;obesogenic;Parent-Child Relations;physical conditioning;Physiological;policy implication;predictive modeling;prenatal;Prevalence;prevent;Prevention;preventive intervention;Process;protective factors;psychologic;psychosocial;Public Health;Public Policy;Race;recruit;Regulation;Research;Research Personnel;response;Risk;Risk Factors;Role;Sampling;Satiation;skills;social;Social Processes;Socioeconomic Status;Solid;Structure;Testing;Time;trait;Weight;Work

PROJECT_TITLE: Food and Non-Food Self-Regulation in Children's Obesity Risk: A Biopsychosocial Perspective

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE The minimum protective tenofovir diphosphate (TFV-DP) concentrations, the active form of tenofovir-based PrEP, in the blood and the level of adherence required to achieve those concentrations may differ depending on the route and frequency of exposure to HIV. Using our combined complementary expertise in HIV prevention research in women and antiretroviral pharmacology, we will define cisgender women-specific adherence- concentration-efficacy benchmarks for TFV moieties in a novel directly observe study of TDF/FTC PrEP in African women, a priority population for HIV prevention. We will then link the newly defined thresholds to the Partners PrEP Study clinical cohort to estimate TFV-DP concentrations associated with HIV protection for women and the minimum adherence level (doses per week) required to achieve these levels.

PI_NAMEs: ANDERSON, PETER L.;MUGWANYA, KENNETH KIGGUNDU (contact)

PROGRAM_OFFICER_NAME: SHARMA, USHA K

PROJECT_TERMS: active control;Adherence;Africa;African;African Women;Age;AIDS prevention;Anti-Retroviral Agents;Archives;Benchmarking;Biological;Blood;Blood specimen;case control;cis-female;Classification;Clinical;Clinical Data;clinical epidemiology;Clinical Pharmacology;Clinical Research;Clinical Trials;cohort;Cohort Studies;Data;Data Pooling;Data Set;design;Development;Diphosphates;Directly Observed Therapy;Disproportionately impacts women;Dose;Drug Exposure;Drug Kinetics;Dryness;emtricitabine;Exposure to;follow-up;Frequencies;Fumarates;Future;Genitalia;High Risk Woman;HIV;HIV Infections;HIV risk;HIV Seropositivity;Human immunodeficiency virus test;implementation study;infection rate;Injectable;International Maternal Pediatric Adolescent AIDS Clinical Trials;Intervention;lens;Link;male;Measurement;Measures;men;men who have sex with men;Methods;Modality;multidisciplinary;novel;Oral;Pattern;Performance;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Plasma;Population;Postpartum Women;pre-exposure prophylaxis;Pregnancy;Pregnant Women;prevent;Prevention Research;Prevention strategy;Randomized;Rectum;Risk;Risk Factors;Route;sample archive;Sampling;scale up;seroconversion;sex;Site;Spottings;standard of care;Study Subject;success;synergism;Tenofovir;Testing;Time;Tissues;Vagina;Visit;Whole Blood;Woman;Women's study;Women's trial;Work

PROJECT_TITLE: PrEP adherence-concentration thresholds associated with HIV protection among African women

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Clinical Research;Emergency Care;Health Services;Neurosciences

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: The knowledge gained from the reliable research produced by the Michigan SIREN Collaborative (MI-SIREN) will guide the care of acute and critical clinical conditions. MI-SIREN allows application of this knowledge to a more diverse, enriched population by recruiting under-resourced subjects. MI-SIREN will perform pragmatic therapeutic trials targeted towards conditions causing significant morbidity and mortality.

PI_NAMEs: KLINE, JEFFREY A;MILLER, JOSEPH BENJAMIN;O'NEIL, BRIAN J. (contact)

PROGRAM_OFFICER_NAME: SCOTT, GRETCHEN CARLYLE

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;African American;Applications Grants;Appointment;Area;Burn Centers;Certification;Clinical;Clinical Trials;Collaborations;Communication;Data;Emergency Care;Emergency department visit;Emergency Medicine;Emergency Situation;Employee;Engineering;Enrollment;Environment;Equipment and supply inventories;experience;Faculty;faculty mentor;Fellowship;Funding;Grant;Health;Health system;Healthcare Systems;Heart failure;Hospitals;improved;Informed Consent;Infrastructure;innovation;Investments;Knowledge;Leadership;Medical;member;Mentored Clinical Scientist Development Program;Mentors;metropolitan;Michigan;Modeling;Morbidity - disease rate;mortality;Myocardial Infarction;next generation;Online Systems;Operative Surgical Procedures;pandemic disease;Participant;Pathway interactions;Patients;Pediatric Hospitals;pediatric trauma;Performance;Phase;Population;Population Heterogeneity;post-COVID-19;Poverty;Productivity;programs;Pulmonary Embolism;recruit;Research;Research Personnel;research study;Resource Allocation;Resource Sharing;Resources;retention rate;Role;Schedule;Scientist;Site;success;Technology;Therapeutic Trials;Time;Training;Training Programs;trauma centers;United States National Institutes of Health;Universities;Virginia;virtual;Visit;working group

PROJECT_TITLE: Michigan SIREN Collaborative