NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Cancer;Brain Disorders;Cancer;Nanotechnology;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Extracellular vesicles (EVs) show great promise as next-generation targeted drug delivery systems, but their complexity and heterogeneity in structure, composition, and function have stalled their translational use. In this study we propose physicochemical approaches to homogenize EVs and fuse them with synthetic drug loaded liposomes to engineer a drug delivery vehicle that delivers a therapeutic payload with high intracranial uptake. We will test the safety and biodistribution of the engineered product as well as its efficacy in a glioblastoma orthotopic mouse model.

PI_NAMEs: CARNEY, RANDY  (contact);WANG, AIJUN

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Astrocytes;Behavior;Biochemical;Biodistribution;Biological;Biological Assay;Biological Availability;Biological Process;biomaterial compatibility;Bioreactors;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;Breast Cancer Cell;Cancer cell line;Cell Line;cell type;Cells;Chemicals;Clinical;clinical practice;combat;Complex;controlled release;delivery vehicle;design;Disease;Disseminated Malignant Neoplasm;Dose;Drug Delivery Systems;drug release profile;Drug Targeting;efficacy study;Endothelium;Engineering;Exhibits;expectation;extracellular vesicles;Failure;FDA approved;Feedback;Formulation;Foundations;functional improvement;Glioblastoma;Goals;Good Manufacturing Process;Half-Life;Heterogeneity;Hybrids;Image;Immune;immune clearance;in vivo;innovation;interest;Label;Libraries;Ligands;Liposomes;loss of function;Malignant neoplasm of brain;Malignant Neoplasms;Measures;Mechanics;Mediating;Medicine;Methods;Microfluidics;mimetics;Modeling;Molecular;mouse model;Mus;nanoarchitecture;nanocarrier;nanomaterials;nanoparticle;nanoscale;Nervous System Disorder;neural;Neurodegenerative Disorders;Neuroglia;Neurons;next generation;novel;novel strategies;particle;Pathway interactions;Patients;Penetration;Performance;personalized care;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phase I Clinical Trials;Population;Property;Proteins;receptor;Reporting;Research;RNA;Safety;safety study;safety testing;Shapes;Solid;Source;Sterility;Structure;success;synthetic drug;System;Techniques;temozolomide;Testing;Therapeutic;Tissues;tool;Toxic effect;transcytosis;Translating;Treatment Efficacy;Tropism;tumor;uptake;Vision;Work

PROJECT_TITLE: Homogenized, engineered extracellular vesicles for intracranial targeting

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Continuous glucose monitoring (CGM) can help improve blood sugar management in type 2 diabetes. A sequential, multiple assignment, randomized trial will evaluate clinical pharmacists, community health workers, and telehealth in supporting CGM use to improve blood sugar control. The study will also investigate the translation of supported CGM into primary care and estimate both cost and cost-effectiveness.

PI_NAMEs: GERBER, BEN STEVEN (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Address;Adoption;Affect;Behavioral;Black race;Blood Glucose;California;cardiovascular risk factor;Caring;Child;Clinical Pharmacists;Community Health Aides;Continuous Glucose Monitor;cost;cost effective;cost effectiveness;cost estimate;diabetes control;diabetes management;Diabetes Mellitus;Disparity;effectiveness evaluation;effectiveness study;ethnic difference;Family Practice;Future;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Health;health care service organization;Healthcare Systems;Hispanic;Hyperglycemia;Hypoglycemia;improved;Individual;Infusion procedures;Injections;Insulin;Insulin-Dependent Diabetes Mellitus;Insurance;Intercellular Fluid;large datasets;Low income;Low Income Population;Massachusetts;Measures;medication compliance;mHealth;minority communities;Minority Groups;Modeling;monitoring device;Neighborhood Health Center;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Observational Study;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmacists;Population;Population Heterogeneity;Primary Care;primary care provider;primary care setting;Quality of life;racial difference;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Resources;secondary outcome;Self Management;sensor;Sequential Multiple Assignment Randomized Trial;social health determinants;Specialist;subcutaneous;Technology;telehealth;Time;tool;Translations;United States;Upper arm;Variant;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Team Support to Improve Glycemic Control Using CGM in Diverse Populations (TEAM CGM)

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative The proposed research is relevant to human health because it will discover specific molecular events that contribute to multiple sclerosis, leading to better diagnostics, treatments, and eventually cures. This project is relevant to the NIH’s mission, and the mission of NINDS in particular, because it will provide fundamental insights into the role of the Epstein-Barr virus and human genetics in the etiology of multiple sclerosis.

PI_NAMEs: KOTTYAN, LEAH CLAIRE;WEIRAUCH, MATTHEW TYSON (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Affect;African ancestry;Alleles;Antibodies;Apoptosis;Asian ancestry;B-Cell Antigen Receptor;B-Lymphocytes;Behavior;Binding;Biological Assay;Blood - brain barrier anatomy;Brain;Cataloging;CD58 Antigens;CD58 gene;Cell Adhesion;cell behavior;Cell Communication;Cell Physiology;Central Nervous System;Central Nervous System Diseases;ChIP-seq;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;cytokine;Data;demographics;Diagnosis;Diagnostic;Disease;Disease remission;Dissection;EBNA2 protein;Endothelium;Environment;Environmental Risk Factor;Epidemiology;Epstein-Barr Virus Infections;Etiology;European ancestry;Event;Female;Foundations;functional genomics;Gene Expression;Genes;Genetic;genetic association;genetic regulatory protein;Genetic Risk;genetic risk factor;Genetic Transcription;genome editing;genome wide association study;genomic locus;Genomic Segment;Genomics;Genotype;Grant;Health;Human;Human Genetics;Human Herpesvirus 4;Immune;Immunoglobulin G;Immunologics;improved;induced pluripotent stem cell;infected B cell;Inflammatory Response;infrastructure development;innovation;insight;Lead;Link;male;Measures;migration;Mission;Modeling;Molecular;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;National Institute of Neurological Disorders and Stroke;notch protein;novel;pandemic disease;Pathway interactions;Patients;Persons;Phenotype;Play;prevent;Prevention;Process;Production;Proliferating;protein complex;Proteins;Receptor Signaling;Relapse;Reporter;Research;Risk;risk variant;Role;Shapes;T-Cell Development;T-Cell Proliferation;T-Lymphocyte;Technology;Testing;therapy development;Time;tositumomab;Trans-Activators;transcription factor;transforming virus;United States National Institutes of Health;vaccine development;Vaccines;Variant;Viral Proteins;Virus;virus genetics;Work

PROJECT_TITLE: Binding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic Mechanisms

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Decreases in cerebral blood flow and brain metabolism are implicated in neurodegenerative diseases, such as Alzheimer’s disease, and cognitive decline. Astrocytes, with processes that completely cover the blood vessels have been shown to regulate local blood flow through multiple mechanisms. The goal of this proposal is to explore a role for one of these mechanisms, controlled by glutamate transporters, in the decreased brain blood flow seen in Alzheimer’s disease

PI_NAMEs: JACKSON, JOSHUA GOODYEAR (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Ablation;Alzheimer's Disease;Alzheimer's disease model;arteriole;Astrocytes;Attenuated;Basal metabolic rate;Bioenergetics;Blood capillaries;Blood flow;Blood Vessels;Brain;brain metabolism;Brain region;Buffers;cell type;Cerebrovascular Circulation;constriction;cost;Development;Diameter;Disease;Elements;Endothelial Cells;Excision;Gene Expression;Genetic;Glucose;glucose metabolism;Glutamate Transporter;Glutamates;Glycogen;Goals;human disease;Impaired cognition;Impairment;in vivo;in vivo imaging;Kinetics;Knowledge;Link;Location;Measures;Mediating;Membrane;Metabolic;Methods;Microscopy;Mitochondria;mitochondrial dysfunction;mouse model;neural;Neurodegenerative Disorders;Neurons;neurovascular;neurovascular coupling;neurovascular unit;operation;Pathology;Pathway interactions;Pericytes;pharmacologic;Positioning Attribute;Process;Protein Isoforms;Proteomics;Regulation;response;Role;Shapes;Signal Pathway;Signal Transduction;Smooth Muscle Myocytes;Somatosensory Cortex;Stimulus;Symptoms;Synapses;Synaptic Cleft;Testing;transcriptomics;Trees;two-photon;Vascular Smooth Muscle;vasoconstriction;Vasodilation

PROJECT_TITLE: Dysregulation of glutamate transporter-dependent neurovascular coupling in Alzheimer's disease


NIH_SPENDING_CATS: Diabetes;Genetics;Obesity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Narrative Type 2 diabetes (T2D) is a highly prevalent metabolic disease for which new therapies are needed. The proposed research would use rare coding human genetic variation to suggest new genes that could be modulated to treat T2D by improving insulin response in fat tissue. The project would combine two approaches – analyses of large-scale human genetic data and high-throughput molecular experiments – to address gaps in our understanding of genes in insulin response pathways and their relationship to human risk of T2D.

PI_NAMEs: FLANNICK, JASON  (contact)

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Ablation;Address;adipocyte differentiation;Adipocytes;Adipose tissue;Affect;biobank;Biological Assay;Biological Process;Clinical;Code;Complement;Data;Data Set;design;Diabetes Mellitus;diabetes risk;Differentiated Gene;Disease;exome;Experimental Genetics;experimental study;Fasting;Fatty acid glycerol esters;Funding;Future;gene function;Genes;Genetic;Genetic Screening;genetic variant;Genetic Variation;glucose uptake;Goals;high body mass index;High Density Lipoproteins;Hip region structure;Human;human disease;Human Genetics;Hypertriglyceridemia;Impairment;improved;In Vitro;in vivo;Insulin;Insulin Resistance;insulin secretion;interest;Knock-out;Knowledge;Knowledge Portal;large datasets;Link;Lipids;loss of function;Measures;Metabolic Diseases;Metabolic syndrome;Methods;Modeling;Molecular;Morphologic artifacts;National Institute of Diabetes and Digestive and Kidney Diseases;Nature;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutics;Nutrient;Pathway interactions;Pharmaceutical Preparations;PPARG gene;Pre-Clinical Model;Predisposition;Probability;Process;Public Health;rare variant;Research;response;Risk;Sample Size;Sequence Analysis;success;Susceptibility Gene;Testing;Therapeutic;therapeutic target;Thiazolidinediones;Tissues;Toxic effect;trait;Treatment Efficacy;Variant

PROJECT_TITLE: In vivo and in vitro rare coding variant analyses to identify modulations of the adipocyte differentiation pathway that affect T2D risk


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dissemination and Implementation Research;Health Services;Kidney Disease;Pediatric;Prevention;Rare Diseases;Spina Bifida;Urologic Diseases

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Although preserving kidney health is prioritized in young patients with spina bifida, current tools and approaches for assessing kidney health are inaccurate, not patient-centered, and not widely implemented. This study will use advanced quantitative, qualitative, and implementation research methods to develop new tools and consensus strategies for assessing kidney health. The new knowledge and interventions developed in this study will be extended to improve kidney, bladder, and overall health among this high-risk population.

PI_NAMEs: CHU, DAVID  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Address;Adolescent and Young Adult;Adult;Advisory Committees;Affect;Assessment tool;Attitude;Award;Belief;Bladder;Cardiovascular Diseases;career;career development;Caregivers;Caring;Catheterization;Centers for Disease Control and Prevention (U.S.);Cessation of life;Childhood;Chronic Kidney Failure;Clinic;clinical epidemiology;clinical practice;Clinical Sciences;cohort;Collaborations;Congenital Abnormality;Consensus;cost;Data;Dedications;Detection;Development;Development Plans;diagnostic strategy;diagnostic tool;Disabling;Disease Progression;Disease Surveillance;Doctor of Philosophy;Early Diagnosis;Educational Intervention;Educational workshop;End stage renal failure;Ensure;Environment;Equation;Evaluation;experience;Extramural Activities;Feasibility Studies;Fostering;Foundations;Funding;Future;future implementation;Glomerular Filtration Rate;Goals;Guidelines;Health;health assessment;health belief;health literacy;Healthcare;high risk population;Impairment;implementation facilitators;implementation intervention;implementation research;implementation science;implementation study;improved;improved outcome;Infant;informant;insight;Institution;instrument;Intervention;Interview;Iohexol;K-Series Research Career Programs;Kidney;Kidney Diseases;kidney preservation;Knowledge;Measures;Medicine;Mentors;Mentorship;Methodology;Modeling;multidisciplinary;Neurogenic Bladder;novel;Operative Surgical Procedures;patient engagement;patient oriented;patient oriented research;Patients;Pediatric Hospitals;Plasma;Population;Positioning Attribute;predictive modeling;Predisposition;preference;pressure;prevent;Process;programs;Prospective, cohort study;Protocols documentation;Provider;provider factors;Public Health;Qualitative Research;Reconstructive Surgical Procedures;reduced muscle mass;Registries;Renal function;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Support;Resources;Review Literature;Scientist;Self Care;Severities;skills;Spinal Dysraphism;standard measure;Structure;Surgeon;Surveillance Methods;surveillance strategy;systematic review;Testing;Theoretical model;tool;Training;Translating;Translational Research;Uncertainty;United States;Universities;urologic;Urology;Validation;validation studies

PROJECT_TITLE: Improving Kidney Health Assessment in Young Patients with Spina Bifida

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: This proposal aims to understand how the RNA-binding protein, IMP1, coordinates essential mechanisms of intestinal epithelial regeneration. Advances made with these studies will allow for the development of new therapeutic strategies that may augment autophagy (or other) pathways in order to restore intestinal epithelial homeostasis. This work has the potential to improve therapy for patients, especially patients who experience injury to the gastrointestinal epithelium as a result of radiation or chemotherapy.

PI_NAMEs: HAMILTON, KATHRYN ELIZABETH (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Ablation;Affect;Apoptosis;ATG3 gene;Attenuated;Autophagocytosis;Binding;Binding Proteins;Biological Assay;cancer cell;Cell Count;cell injury;Cell Line;Cell Separation;Cells;Cellular biology;Chemicals;Chemotherapy and/or radiation;Clinical;colon cancer cell line;Colon Carcinoma;Cytoprotection;Data;Development;Disease;DNA Damage;Epithelial Cells;Epithelium;epithelium regeneration;Exhibits;experience;Flow Cytometry;functional group;gastrointestinal epithelium;Gastrointestinal Injury;Gene Deletion;Genes;Genetic;Goals;Homeostasis;Hydroxychloroquine;IGF2 gene;Immunofluorescence Immunologic;improved;Infection;Inflammation;inhibition of autophagy;Injury;innovation;intestinal epithelium;intestinal injury;Intestines;irradiation;Kinetics;Knock-out;LGR5 gene;Link;Luciferases;Mediating;Messenger RNA;Modeling;Molecular;mouse model;Mus;Natural regeneration;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;overexpression;Paneth Cells;Pathway interactions;Patients;Post-Transcriptional Regulation;posttranscriptional;Predisposition;prevent;Process;Proteins;Radiation;Radiation Tolerance;radiation-induced injury;radioresistant;Reactive Oxygen Species;Regenerative capacity;Regulation;Regulon;repaired;Reporter;response;ribosome profiling;Ribosomes;RNA Biochemistry;RNA-Binding Proteins;Role;self-renewal;stem cell function;stem cell self renewal;stem cells;Stress;Testing;Tissues;Toxin;Transcript;Translations;Up-Regulation;Vesicle;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Defining post-transcriptional regulons in intestinal epithelial regeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-D(90)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE We have described two different subtypes of progressive apraxia of speech (PAOS), known as the phonetic and prosodic subtypes, and in cycle 1 of this grant prove that there are important differences at presentation between the subtypes, as well as different associations with two Alzheimer’s disease related tauopathies. In cycle 2, we plan to study 120 patients with PAOS, follow those who are living over time to see how the disease evolves, perform new types of brain scan techniques, and study the largest collection of autopsied brains on PAOS to better understand how brain damage relates to subtype. Knowledge gained from cycle 2 will help to improve diagnosis, provide patients with useful information to help them better prepare for the future, and help to explain the cause of PAOS.

PI_NAMEs: JOSEPHS, KEITH A (contact);UTIANSKI, RENE LYNN

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Alzheimer's Disease;Alzheimer's disease related dementia;Anatomy;Aphasia;Apraxia;Atrophic;Autopsy;Biological;Brain;Brain Injuries;Brain scan;Brain Stem;brain volume;Cerebellum;Characteristics;Clinical;clinical development;Clinical Trials;clinically relevant;Collection;Communication;Corpus striatum structure;corticobasal degeneration;cost;Cross-Sectional Studies;Data;Data Collection;Deposition;Development;Diagnosis;Differential Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;disease prognosis;Disease Progression;Dysarthria;Evolution;experience;fluorodeoxyglucose positron emission tomography;Frequencies;Functional Magnetic Resonance Imaging;Future;Genetic;Genetic Risk;genetic risk factor;Grant;Haplotypes;Image;improved;indexing;Intervention;Iron;Knowledge;Language;Language Disorders;Language Therapy;life span;Magnetic Resonance Imaging;Maps;Measures;metabolic rate;Metabolism;Methods;morphometry;Mutism;Nerve Degeneration;Neurobiology;neuroimaging;neuroimaging marker;Neurologic;Neurologist;neuron loss;neuropathology;novel;Outcome;Parkinson Disease;Pathologic;Pathologist;Pathology;Patient Care;Patients;Phenotype;Phonetics;Play;Predisposition;prognostic;prospective;Reporting;response;risk variant;Role;Severities;Speech;Speech Disorders;Structure;Syndrome;tau Proteins;Tauopathies;Techniques;Time

PROJECT_TITLE: The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: RNA abundance and lifetime is regulated by fundamental processes that includes the eukaryotic RNA exosome and its upstream cofactors, essential multi-subunit complexes that contribute to RNA homeostasis through 3’ to 5’ processing and degradation in surveillance pathways that monitor the quality of nuclear and cytoplasmic RNA and in signaling to control the duration of RNA expression. Post-translational protein modification by ubiquitin (Ub) and ubiquitin-like (Ubl) proteins such as SUMO (small ubiquitin-like modifier) regulate protein activities in processes that include the cell cycle, protein degradation, protein localization, nuclear transport, cytokinesis, chromosome segregation, and transcriptional regulation. This proposal seeks to continue exploration of these essential eukaryotic processes of Ub/Ubl-protein modification and RNA decay through structural, biochemical and genetic studies that will illuminate molecular mechanisms underlying defects associated with human diseases that include cancer, inflammation, and neurodegenerative disorders.

PI_NAMEs: LIMA, CHRISTOPHER D. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Address;Biochemical;Biology;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Physiology;Chemicals;Chromosome Segregation;cofactor;Complex;Cytokinesis;Cytoplasm;Defect;Disease;Enzymes;Equilibrium;Eukaryota;Exoribonucleases;exosome;Genes;Genetic;Genetic study;Genetic Transcription;Health;Homeostasis;Human;human disease;In Vitro;in vivo;Inflammation;Life;Ligase;M cell;Malignant Neoplasms;Metabolism;Mission;Modification;Molecular;Monitor;Motor;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Nuclear;nucleic acid metabolism;nucleocytoplasmic transport;Pathway interactions;Peptide Hydrolases;Play;Post-Translational Protein Processing;Process;Protein Complex Subunit;protein degradation;Proteins;receptor;reconstitution;Regulation;Reporting;RNA;RNA Decay;RNA Processing;RNA purification;Role;Saccharomycetales;Signal Transduction;Structure;Transcriptional Regulation;Ubiquitin;Ubiquitin Like Proteins;United States National Institutes of Health

PROJECT_TITLE: Structural studies of RNA processing and ubiquitin-like protein modification

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: Project Narrative Blood flow through the brain capillaries is impaired in Alzheimer’s disease, and preclinical research is needed to understand the bases for this impairment and to identify therapeutic avenues to improve capillary flow. This project will use cutting-edge microscopy and genetic approaches in live mice to study pericytes, a cell type that regulates capillary blood flow, and determine how contractile signals to these cells contributes to normal blood flow and reduced blood flow in models of Alzheimer’s disease-like pathology.

PI_NAMEs: SHIH, ANDY Y (contact)

PROJECT_TERMS: abeta accumulation;Actins;Actomyosin;Address;Affect;Agonist;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease related dementia;Architecture;awake;base;Behavioral;behavioral outcome;Biology;Blood capillaries;Blood flow;Blood Vessels;Brain;brain health;brain tissue;career;cell type;Cells;Central Nervous System;Cerebral Amyloid Angiopathy;cerebral capillary;cerebral hypoperfusion;cerebral microvasculature;Cerebrovascular Circulation;Cerebrum;Chronic;Cognition;Collaborations;constriction;Contracts;Cre driver;Cytoskeleton;designer receptors exclusively activated by designer drugs;Diameter;Endothelin-1;Energy Supply;Ensure;experimental study;Gene Deletion;Genes;Genetic;genetic approach;GTP-Binding Proteins;Health;Heterogeneity;Human;Hyperemia;hypoperfusion;Hypoxia;Image;imaging approach;Impaired cognition;Impairment;improved;in vivo;in vivo imaging;in vivo two-photon imaging;inhibitor;innovation;Knowledge;Link;Microscopy;Modeling;Mus;neuroinflammation;next generation;novel;optogenetics;Pathology;Pattern;Perfusion;Pericytes;pharmacologic;pre-clinical research;preclinical study;protein activation;receptor;Receptor Gene;Receptor Signaling;Regulation;Research;Research Personnel;Resources;Role;Scientist;Signal Transduction;Signaling Protein;Slice;Smooth Muscle;Smooth Muscle Myocytes;Testing;Therapeutic;Thromboxane A2 Receptor;Tissues;Titrations;tool;Training Support;two-photon;white matter;Work

PROJECT_TITLE: Pericyte control of capillary perfusion in the Alzheimer's disease brain


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: HOUSTON

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

ORG_STATE: TX

PHR: The occurrence of increased cardiovascular-disease mortality among patients with very high plasma concentrations of high-density lipoproteins (HDL), the so-called “good cholesterol,” is a paradox for which underlying mechanisms are unknown. HDL is richer in free cholesterol (FC) in animal models of this disorder than in normal animals, so we will test in humans the hypothesis that, compared to normal patients, those with high HDL concentrations and cardiovascular disease have HDL that is richer in FC that rapidly transfers to macrophages, a key cell type in the development of cardiovascular disease. Validation of our hypothesis would provide a compelling rationale for the validation of diagnostics that quantify HDL-FC levels and for the development of therapeutic inhibitors of HDL-to-macrophage FC transfer.

PI_NAMEs: NASIR, KHURRAM ;POWNALL, HENRY J. (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: Affect;Animal Model;Animals;Arterial Fatty Streak;athero susceptible;atherogenesis;atheroprotective;Atherosclerosis;Biological Availability;Biological Markers;Calcium;Cardiovascular Diseases;cardiovascular disorder risk;cell type;Cholesterol;Cholesterol Esters;Code;Coronary;coronary calcium scoring;Data;Development;Diagnosis;Diagnostic;disease diagnostic;disease model;Dose;effective therapy;Esterification;Etiology;Foam Cells;Formulation;genetic variant;Goals;High Density Lipoprotein Cholesterol;high density lipoprotein receptor;High Density Lipoproteins;Human;indexing;inhibitor therapy;Intervention;Link;Lipids;Lipoproteins;Low-Density Lipoproteins;Macrophage;Measures;Metabolic;Metabolic Diseases;Metabolism;Methods;Modeling;Molecular;mortality;Mus;Mutation;Nuclear Magnetic Resonance;overexpression;particle;Patient Transfer;Patients;Persons;Phenotype;Phosphatidylcholine-Sterol O-Acyltransferase;Physicians;Physiological;Plasma;Predictive Value;Probucol;Process;Proteins;Reporting;Residual state;response;reverse cholesterol transport;Risk;Risk Factors;Role;Severities;Source;Subgroup;Sum;Testing;therapeutic development;trend;Validation;validation studies;Wild Type Mouse

PROJECT_TITLE: Human Atherogenesis with Underlying Dysfunctional HDL-Free Cholesterol

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - B;Infectious Diseases;Liver Cancer;Liver Disease;Mental Health;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Project Narrative The burden of chronic hepatitis B (CHB) is greater among foreign-born Asian Americans who account for more than 50% of Americans living with CHB. The proposed study leverages our two unique clinic-based cohorts of CHB patients to examine the multi- step and multi-level process to chronic liver diseases and liver cancer. Our prospective longitudinal study will provide the groundwork to understand the etiology and mechanisms of disparities in chronic liver disease progression in among Asian Americans and other high-risk populations.

PI_NAMEs: JUON, HEE-SOON  (contact);KLASSEN, ANN CARROLL

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Accounting;Acculturation;acute infection;Adherence;adverse outcome;Alcohols;American;Asian;Asian Americans;Behavior;Behavioral;Biological;Biological Markers;biological systems;biopsychosocial;Birth;Buffers;Cancer Etiology;care seeking;Caring;Cessation of life;Characteristics;Chronic;Chronic Disease;Chronic Hepatitis B;chronic liver disease;Clinic;Clinical;Clinical Data;cofactor;cohort;Collaborations;Communicable Diseases;coping;Coping Skills;COVID-19;curative treatments;Data;Development;Diabetes Mellitus;Diet;Discrimination;Disease;disease disparity;Disease Outcome;Disease Progression;disorder prevention;Disparity;Disparity population;disparity reduction;DNA Damage;end stage liver disease;Endogenous Factors;Enrollment;Environmental Exposure;ethnic discrimination;ethnic health disparity;ethnic identity;Ethnic Origin;Ethnic Population;Etiology;Exogenous Factors;experience;Goals;Health;health disparity;health disparity populations;Healthcare;Hepatic;Hepatitis B Incidence;Hepatitis B Infection;Hepatitis B Virus;Hepatocarcinogenesis;high risk;high risk population;Immune system;Impairment;Individual;Inflammation;insight;Intervention;Interview;Korea;Korean American;Language;Liver;Liver Cirrhosis;Liver diseases;liver infection;longitudinal, prospective study;Los Angeles;Malignant neoplasm of liver;Mediating;Medical;Metabolic;Metabolic Diseases;Methods;migration;Minority Groups;Modeling;multilevel analysis;neglect;neighborhood disadvantage;Obesity;oxidative DNA damage;Pathway interactions;Patients;Pattern;Phenotype;Philadelphia;Policies;Population;preference;premature;Prevalence;Primary carcinoma of the liver cells;Process;Protocols documentation;psychosocial;Psychosocial Factor;racial health disparity;recruit;repository;Research;Risk;Role;Science;Severity of illness;social;social stigma;social stressor;Stigmatization;stressor;Structure;Time;Tobacco;treatment adherence;Treatment Effectiveness;University Hospitals;Variant;Virus;Virus Diseases;Visit;Work

PROJECT_TITLE: Bio-Psycho-Social Drivers of Disparities in Liver Disease Progression among Korean Americans with Hepatitis B Infection

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Digestive Diseases;Genetics;Human Genome;Microbiome;Nutrition;Precision Medicine;Prevention

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

PHR: PROJECT NARRATIVE The ecological structure of the human gut microbiome helps determine nutritional and phenotypic responses to diet. However, a clear mapping does not yet exist between diet, gut microbial ecology, gut microbial community metabolism, and human metabolic phenotypes. In this proposal, we design and test an integrated host- microbiome-diet metabolic model for rapidly and accurately predicting personalized responses to dietary inputs.

PI_NAMEs: GIBBONS, SEAN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Adult;Algorithms;Amendment;Bile Acids;Biochemical;Biochemical Pathway;bioinformatics tool;Biological;Biological Assay;Biological Markers;Blood;blood lipid;Body Weight decreased;cell type;cohort;Colon;commensal microbes;Communities;Complex;Custom;Data;Data Set;design;Diet;dietary;Dietary Assessment;Dietary Component;Dietary intake;Dietary Intervention;Digestion;Ecology;Ecosystem;Environment;experience;experimental study;fecal metabolome;fecal microbiome;Feces;Foundations;gastrointestinal epithelium;genome-wide;Growth;gut microbiome;gut microbiota;Health;Heterogeneity;host microbiome;Human;Human Microbiome;improved;in silico;In Vitro;in vivo;Incubated;Individual;innovation;Intervention;Knowledge;Maps;Measurement;Measures;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;metagenome;Metagenomics;Microbe;microbial;microbial community;microbiome;microbiome composition;microbiome research;model building;Modeling;Mucins;Multiomic Data;novel;nutrition;Nutritional;Organ;Participant;personalized predictions;Persons;Pharmaceutical Preparations;Phenotype;Physiology;Polysaccharides;Precision Health;precision nutrition;predictive modeling;Production;Publishing;reconstruction;recruit;Resources;response;Sampling;Seminal;stem;stool sample;Structure;Systems Biology;Testing;Tissues;tool;Training;Validation;Variant;Vitamins;Work

PROJECT_TITLE: CyberGut: towards personalized human-microbiome metabolic modeling for precision health and nutrition


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative We propose to study how mothers’ exposures to wildfire and intentional biomass burning during pregnancy may affect whether her baby is born prematurely. We will also evaluate the role of neighborhood deprivation and race/ethnicity may modify the relationship between fire exposures and preterm birth.

PI_NAMEs: PADULA, AMY MICHELLE (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: 37 weeks gestation;Accounting;Address;Adult;Affect;Agriculture;Air;Air Pollutants;Air Pollution;ambient air pollution;American;Area;Aromatic Polycyclic Hydrocarbons;Biomass;Birth;Birth Records;Burn injury;California;Categories;Censuses;Chemicals;Childhood;combustion product;Communities;Community Surveys;consumer product;Consumption;County;criteria air pollutant;critical period;Data;Data Set;deprivation;Disparity;Environmental Exposure;Ethnic Origin;Event;Exposure to;fine particles;Fire - disasters;fire prevention;Future;Gestational Age;Health;High Prevalence;Housing;Income;indexing;Individual;Industrialization;Knowledge;Live Birth;Location;low socioeconomic status;Measures;Modeling;Monitor;Morbidity - disease rate;Mothers;Neighborhoods;Particulate Matter;perinatal health;Perinatal mortality demographics;pollutant;Population;Poverty;Pregnancy;Pregnant Women;premature;Premature Birth;prenatal exposure;Psychosocial Stress;Race;Regulation;Research;Research Personnel;residence;Risk;Risk Factors;Role;Seasons;Second Pregnancy Trimester;Severities;Smoke;Socioeconomic Status;Source;Stress;Structure;Temperature;United States;wasting;Wildfire;Wood material

PROJECT_TITLE: Wildfires and intentional biomass burning in California and Preterm Birth


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunization;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: Project narrative: We propose to develop a novel engineered T cell therapy against malignant mesothelioma, a rare and incurable cancer. We have developed a prime-and-kill circuit T cell that targets a tumor specific cell surface antigen to activate the circuit and a credentialed tumor associated antigen to enhance anti-tumor activity and overcome limitations associated with current cell therapies in solid tumor treatment.

PI_NAMEs: LIU, BIN ;ROYBAL, KOLE T (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Address;Affinity;Alkaline Phosphatase;Antibodies;antibody engineering;antigen binding;Antigen Targeting;Antigens;B lymphoid malignancy;Bacteriophages;Binding;Biological Markers;CAR receptor;CAR T cell therapy;CD8B1 gene;Cell surface;Cell Therapy;chimeric antigen receptor T cells;Clinic;Clinical;clinical efficacy;clinical translation;Collaborations;Credentialing;cytokine;design;Development;DNA Binding Domain;engineered T cells;Engineering;exhaustion;extracellular;Family;flexibility;Generations;Genes;Goals;Human;human DNA;human monoclonal antibodies;human tissue;Immune;Immune response;Immunoglobulin Fragments;immunoregulation;improved;In Vitro;in vivo;Laboratories;Libraries;Logic;Malignant mesothelioma;Malignant Neoplasms;member;mesothelin;Mesothelioma;Modeling;Nature;neoplastic cell;Normal tissue morphology;notch protein;novel;novel strategies;novel therapeutics;patient biomarkers;patient stratification;Patient-Focused Outcomes;Patients;Placenta;placental trophoblasts;Preclinical Testing;Prognosis;Proteolysis;Rare Diseases;receptor;Refractory;Relapse;Reporting;Research;research clinical testing;Sampling;Seminoma;Signal Transduction;Site;Solid Neoplasm;Specificity;Specimen;success;Surface Antigens;synthetic antibodies;System;T cell therapy;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Technology;Testing;therapeutic development;Tissues;Toxic effect;Transactivation;Transcriptional Activation;translational potential;Translations;Treatment Efficacy;tumor;Tumor Antigens;tumor microenvironment;Viral Proteins;Work;Xenograft Model;yeast protein

PROJECT_TITLE: Combination antigen sensing engineered T cell for precise recognition and enhanced elimination of solid tumors

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Improved education in childhood is thought to improve adult health and brain function. Our grant proposal will show whether it is possible to conduct an ambitious study in which we hope to re-contact 11,240 participants in a successful education experiment that began in 1985. This will allow us to understand whether students in small size classrooms age better, have better physical health, and have better brain health than students who were in regular size classrooms.

PI_NAMEs: MUENNIG, PETER A (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Achievement;Address;Adult;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Applications Grants;biological age;Biological Aging;Biological Process;Black American;Blood specimen;Brain;brain health;caucasian American;Cause of Death;Cessation of life;Child;Childhood;Chronic Disease;cohort;Cohort Studies;Collaborations;Collection;college;Communities;Control Groups;cost;Credentialing;Crime;Data;data repository;Data Set;design;Development;Diet;Differential Mortality;disorder prevention;disparity elimination;disparity reduction;Distal;early childhood;Education;Educational Intervention;Electronic Mail;Exercise;experience;experimental study;follow-up;Fostering;Funding;Future;graduate school;Graduation Rates;Grant;Health;healthy aging;high school;high school degree;Home;Household;Impact evaluation;improved;Incidence;Income;indexing;Intervention;Investigation;Laboratories;Life;Life Cycle Stages;Link;Longitudinal Studies;Measures;middle age;mortality;Neighborhoods;Outcome;Ownership;Participant;physical conditioning;population health;Poverty;Premature aging syndrome;Premature Mortality;Probability;prospective;Psychological Stress;Randomized;Randomized, Controlled Trials;rate of aging;Recontacts;Records;Research;Risk Factors;Savings;Schools;Smoking;social determinants;social health determinants;Standardization;Students;success;Surveys;teacher;Telephone;Tennessee;Testing;Time;treatment group;United States;willingness

PROJECT_TITLE: The Project STAR Healthy Aging Experiment

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Fuchs Endothelial Corneal Dystrophy (FECD) is an age-related degenerative disease, the primary cause of progressive blindness from corneal endothelial cell death and the second most common cause of corneal transplants in people above 40 years old in the U.S.A. In FECD, prominent stress factors such as oxidative, ER and Mitochondria stress contribute to cell death of corneal endothelial cells, whose primary function is to maintain corneal transparency. Understanding the cross talk between these stress factors may facilitate the development of pharmacological treatments for FECD patients.

PI_NAMEs: KUMAR, VARUN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Accounting;Adenosine Triphosphate;Affect;Age;age related;antioxidant enzyme;Antioxidants;Apoptosis;Apoptotic;Award;Bioenergetics;biological adaptation to stress;Biological Availability;Biology;Blindness;career development;Cell Death;Cell Line;Cellular biology;Collaborations;Complex;Cornea;Corneal Endothelium;Data;Dedications;defined contribution;Degenerative Disorder;Deposition;Development;Disease;DNA Damage;Down-Regulation;Economics;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelial Cells;Endothelium;Extracellular Matrix;Extracellular Matrix Proteins;Female;Fuchs' Endothelial Dystrophy;Genetic Transcription;Glare;Goals;Human;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;insight;Intervention;Investigation;Keratoplasty;Learning;light scattering;Link;Mediating;Medical;medical schools;Membrane Potentials;Mentors;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial membrane;Morphology;mouse model;Mus;novel;NQO1 gene;Nuclear;Oxidants;oxidative DNA damage;Oxidative Stress;Oxidoreductase;Oxygen Consumption;Pathogenesis;Pathway interactions;Patients;Persons;Pharmacological Treatment;Phase;Population;Predisposition;Production;Proteins;Quinones;Reactive Oxygen Species;Reporting;Research Activity;Research Personnel;Resource Development;response;Role;Signal Transduction;social;Stress;Structure;Tissues;Training;Tubular formation;Up-Regulation;UVA induced;Visual

PROJECT_TITLE: Understanding Endoplasmic Reticulum-Mitochondrial Cross-Talk in Corneal Endothelial Cells

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE Oxidative stress, caused by excessive reactive oxygen species (ROS) production, can lead to cell and tissue damage, and thus contributes to the development of various chronic conditions such as aging, cancer, diabetes and heart diseases. This proposal aims to dissect the molecular mechanism underlying an enzyme family called NADPH oxidases, the primary function of which is to produce ROS. Outcomes of our research program will lay the foundation for the development of new strategies to combat oxidative stress.

PI_NAMEs: LEE, CHIA-HSUEH  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Affect;Aging;Binding;Biochemical;Biological;Biological Assay;Biology;Biophysics;Cell membrane;Cells;Cellular biology;Cellular Membrane;Chronic;combat;Complex;Cryoelectron Microscopy;Data;Dedications;Development;Diabetes Mellitus;dimer;Disease;DNA;Drug Design;drug development;Drug Targeting;Electron Transport;Enzymes;extracellular;Extracellular Domain;Family;Family member;flexibility;Foundations;Growth;Health;Heart;Heart Diseases;Homeostasis;hormone biosynthesis;Hormones;Human;human disease;Image;Immune response;improved;insight;Interdisciplinary Study;Invaded;Knowledge;Length;Life;Link;Lung;Maintenance;Malignant Neoplasms;Mammals;Maps;Mediating;member;Membrane;Molecular;Mutation;NADP;NADPH Oxidase;Neurodegenerative Disorders;novel;novel therapeutics;Organ failure;Organism;Outcome;Oxidative Stress;Oxidoreductase;Oxygen;particle;pathogen;Physiological;Physiological Processes;Physiology;Plants;Play;preservation;Process;Production;programs;protein activation;Protein Family;Protein Isoforms;protein oligomer;Proteins;Rationalization;Reactive Oxygen Species;Regulation;Reporting;Research;Resolution;response;Role;Second Messenger Systems;structural biology;Structure;Structure-Activity Relationship;Techniques;Testing;Tissues;Viral;Virus;Virus Diseases

PROJECT_TITLE: Molecular Mechanisms Underlying Mammalian NADPH Oxidase Activation and Regulation

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Microbiome;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  This project explores the possibility of creating Chimeric Antigen Receptor bacteria (CAR-bacteria) that can be used to target and destroy cancer cells. We combine the expertise of nanobody-mediated targeting (Chang), cancer immunology (Bui), and a synchronized lysis circuit (Hasty) to create truly novel “bugs as drugs”. Future studies could optimize the circuitry, recognition, and payload in the bacteria to provide even higher therapeutic efficacy.

PI_NAMEs: BUI, JACK D;CHANG, GEOFFREY A (contact);HASTY, JEFF M

PROGRAM_OFFICER_NAME: RASOOLY, AVRAHAM

PROJECT_TERMS: Affinity;Animal Model;antigen challenge;Antigen Targeting;Bacteria;Bilateral;Binding;cancer cell;Cell Death;Cell Line;Cells;Cervical;chimeric antigen receptor;Complex;Cytolysis;Data;Dose;Engineering;Engraftment;Evolution;experimental study;Future;Goals;Growth;Head and Neck Cancer;HLA-A2 Antigen;HPV positive;Human;Human Cell Line;human model;Human Papillomavirus;improved;in vivo;Innate Immune Response;innovation;intraperitoneal;invention;Kinetics;knock-down;Label;Libraries;Major Histocompatibility Complex;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measures;Mediating;Methods;Molecular Evolution;Mouthwash;Mus;nanobodies;neoplastic cell;novel;Oncoproteins;oral bacteria;overexpression;Pattern;Peptide/MHC Complex;Peptides;Pharmaceutical Preparations;Physiologic pulse;Population Density;prevent;Production;Proteins;Research;response;Specificity;systemic toxicity;T-Lymphocyte;technology platform;Therapeutic;Toxic effect;Treatment Efficacy;tumor;tumor growth;tumor immunology;Tumor Specific Peptide;Viral;Work;Xenograft Model

PROJECT_TITLE: Optimization of CAR-Bacteria for Oral Cancer


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Teenage Pregnancy;Women's Health Research

ORG_CITY: WACO

ORG_NAME: BAYLOR UNIVERSITY

PHR: PROJECT NARRATIVE Adolescent females detained or on probation in juvenile justice settings present with a unique health risk profile, including elevated risk of unplanned pregnancy, substance use, HIV/STI infection, and the overlapping risk of substance-exposed pregnancy. This study will test the efficacy of a targeted bundled prevention intervention for this vulnerable population, many of whom are ethnic minorities disproportionately at risk.

PI_NAMEs: PARRISH, DANIELLE ELIZABETH (contact);VON STERNBERG, KIRK

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Address;Adolescent;adolescent woman;Adult women;Affect;Alcohol consumption;alcohol exposure;alcohol risk;alcohol risk reduction;Alcohols;Behavior;behavior change;Behavior Therapy;Behavioral;Cognitive;Communities;Conceptions;condoms;consistent condom use;Criminal Justice;design;Development;Diversion Program;efficacy evaluation;efficacy testing;efficacy trial;ethnic minority;Ethnic Origin;Female;Female Adolescents;Female of child bearing age;follow-up;Gender;Goals;Health;Health behavior change;high risk;High Risk Woman;HIV;improved;Individual;Infection;infection risk;Informal Social Control;Intervention;Journals;Justice;juvenile justice system;Low Prevalence;male;Marijuana;marijuana cessation;marijuana use;Mediating;Mediator;Minority;Mobile Health Application;Motivation;motivational enhancement therapy;Nature;nicotine use;peer;Pilot Projects;Population;post intervention;Pregnancy;pregnant;prevent;preventive intervention;probation;Process;programs;Public Health;Race;racial diversity;racial population;Readiness;Recording of previous events;reduced alcohol use;Reporting;Research;Risk;Risk Behaviors;Risk Reduction;Services;sexual risk behavior;sexually active;Sexually Transmitted Diseases;skills;societal costs;standard care;substance use;substance use prevention;Teenagers;Testing;Theoretical model;therapy design;Time;Tobacco;Underserved Population;unintended pregnancy;Vulnerable Populations;web site;Woman;Work;young woman;Youth

PROJECT_TITLE: CHOICES-TEEN: Efficacy of a Bundled Risk Reduction Intervention for Juvenile Justice Females

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Diabetes self-management training (DSMT) is an evidence-based, recommended guideline of diabetes care that is underutilized, especially among underserved patient populations disproportionately affected by type 2 diabetes. Patient-facing Health Information Technologies and behavior change approaches inspired by Behavioral Economics can be used to increase engagement with DSMT. The specialized training and expert mentorship provided in this K01 will guide the specific aims of the project to culturally adapt, usability test and conduct a feasibility evaluation of the ‘DM-BOOST para Latinx’ intervention, designed to increase patient engagement and experience with DSMT among Spanish-speaking Latinx patients.

PI_NAMEs: AMANTE, DANIEL JOHN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Appointments and Schedules;Architecture;Award;barrier to care;Behavior;behavior change;Behavior Therapy;behavioral economics;behavioral health;beneficiary;Binding;Body Weight decreased;care systems;career;Caring;Certification;Chronic Disease;Clinical;clinical encounter;Clinical Research;Collaborations;Communities;community engagement;Community Health;Competence;consumer behavior;culturally appropriate intervention;Decision Making;design;Development;diabetes management;Diabetes Mellitus;diabetes self-management;Disparity;Distress;Doctor of Philosophy;Education;Educational Intervention;Effectiveness;Evaluation;evidence base;evidence based guidelines;experience;Extended Family;Face;financial incentive;Foundations;Fright;Funding;Future;Glycosylated hemoglobin A;Goals;Guidelines;Health;health care delivery;health information technology;health training;Healthcare Systems;High Prevalence;Human;implementation barriers;implementation evaluation;improved;innovation;Intention;Intervention;Interview;iterative design;K-Series Research Career Programs;Knowledge;Language;Latinx;Latinx population;Limited English Proficiency;Marketing;Medical;Medicare;Mentored Research Scientist Development Award;Mentors;Mentorship;Modeling;Morbidity - disease rate;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Outcome;outreach;patient engagement;Patient Outcomes Assessments;patient population;Patients;Pattern Recognition;peer;personalized intervention;Physicians;Population;Positioning Attribute;preference;Process;process evaluation;programs;Provider;Questionnaires;Randomized;Recommendation;Research;Research Training;Risk;satisfaction;Schedule;Science;Scientist;Self Care;Self Efficacy;Self Management;Self-control as a personality trait;skills;social;social health determinants;Spanish;Specialist;Technology;telehealth;Testing;theories;therapy design;Training;Translating;Transportation;treatment as usual;Underserved Population;Uninsured;United States National Institutes of Health;uptake;usability;virtual;Work;Writing

PROJECT_TITLE: DM-BOOST para Latinx: a Diabetes Mellitus program using Behavioral economics to Optimize Outreach and Self-management support with Technology for Latinx patients

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK(M1)-1-B]


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Pancreatic cancer is one of the deadliest major cancers, and treatment strategies have not improved significantly for decades. A hallmark of pancreatic cancer is the formation of a dense stromal compartment, which provides metabolic support to the cancer cells and limits therapeutic efficacy. The goal of this proposal is to elucidate the mechanisms of metabolic crosstalk between the stroma and the pancreatic cancer cells that facilitate tumor growth and promote therapeutic resistance.

PI_NAMEs: LYSSIOTIS, COSTAS ANDREAS (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Alleles;Anabolism;Biochemical;Blood Vessels;cancer cell;cancer type;cell growth;Cell Proliferation;cell type;Cells;chemotherapy;clinical application;Clinical Trials;Coculture Techniques;Communication;density;Deposition;Desmoplastic;Disease;effective therapy;efficacy evaluation;Environment;Excision;Extracellular Matrix;Fibroblasts;Generations;Genetic;Genetically Engineered Mouse;Goals;Growth;Homeostasis;Human;human model;Hypoxia;Immunocompetent;Immunotherapy;Impairment;improved outcome;In Vitro;in vivo;inhibitor;insight;interest;Isotopes;KRASG12D;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Mitochondrial Aspartate Aminotransferase;mitochondrial metabolism;Modeling;Modernization;mouse model;Mutation;NADH;NADH oxidase;Neoplasm Transplantation;Non-Malignant;novel;Nutrient;Oncogenic;Organelles;Organoids;oxidation;Oxidation-Reduction;Oxygen;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Physiological;pressure;prevent;Proliferating;Property;Pyruvate;Pyruvate Metabolism Pathway;Radiation;Reaction;Reporting;Research Proposals;Resistance;Role;Scheme;Series;Signal Pathway;Signal Transduction;Stromal Cells;Survival Rate;System;targeted agent;targeted treatment;Techniques;Testing;Therapeutic;therapy resistant;Translations;Transplantation;Treatment Efficacy;treatment strategy;tumor;tumor growth;tumor metabolism;tumor microenvironment;Tumor Promotion;tumor xenograft;Vascularization;wasting;Work;Xenograft procedure

PROJECT_TITLE: Stromal metabolism promotes therapeutic resistance in pancreatic cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Cancer;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Neurotoxic damage to the nervous system weighs heavily in patients’ decision to use chemotherapy for its life-saving benefits in treating cancer. The toxic effects of the most commonly used and successful chemotherapies significantly reduce quality of life by causing neurological disorders both during and long after treatment, causing pain, strange sensations, fatigue, and difficulty with balance and walking. Building on our recent discoveries, the preclinical studies we propose take a new direction that has the promising potential to identify novel targets for treating neurotoxic damage the neurons ultimately responsible for movement disorders.

PI_NAMEs: COPE, TIMOTHY C (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Action Potentials;Acute;acute symptom;Afferent Neurons;Aftercare;Animals;Axon;biophysical analysis;Biophysical Process;Biophysics;Blood - brain barrier anatomy;bodily sensation;Cancer Survivor;Central Nervous System;channel blockers;chemotherapy;chemotherapy induced neuropathy;Chemotherapy-Oncologic Procedure;Chronic;Cimetidine;Cisplatin;Clinical;Clinical Trials;Closure by clamp;common symptom;Consensus;Data;design;Development;Distress;Dose;Dysesthesias;Electrophysiology (science);Equilibrium;Esthesia;evidence base;Exclusion;Exhibits;experimental study;extracellular;Fatigue;Fire - disasters;Functional disorder;Human;immunoreactivity;in vivo;Infiltration;inhibitor;Ion Channel;Knowledge;Lidocaine;Life;Long term disability;Malignant Neoplasms;Measures;meetings;Methods;Modeling;Motor Neurons;Movement Disorders;Muscle;Muscle Contraction;Muscle Cramp;Muscle fasciculation;Nervous System;Nervous System Disorder;neural;neuronal cell body;neuronal excitability;Neurons;neurotoxic;neurotoxicity;novel;Outcome;oxaliplatin;Pain;Patients;Peripheral;Peripheral Nervous System;Persons;Platinum;pre-clinical;preclinical study;prevent;Prevention;Preventive measure;Preventive treatment;Property;Quality of life;Rattus;Research Project Grants;response;Sensory;Severities;Signs and Symptoms;Site;somatosensory;Spasm;Spinal;Spinal Ganglia;spinal nerve posterior root;success;symptom treatment;Symptoms;Synapses;Testing;Thinking;Toxic effect;treatment effect;Voltage-Clamp Technics;Walking

PROJECT_TITLE: Mechanisms underlying spontaneous firing by motoneurons with acute neurotoxicity

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

PHR: Project Narrative The mandate of NIDDK is to reduce the disease burden of diabetes and other hormonal diseases, obesity, kidney and gastro-intestinal and liver diseases in the US and the world at large. We need to provide the scientific manpower to lead this effort and this proposal aims to enhance the pipeline by interesting medical students to do research in these fields. In the past 4 years we have supported 51 students in laboratories of successful scientists who investigate the nature and treatment of these diseases.

PI_NAMEs: AL-AWQATI, QAIS  (contact);PAJVANI, UTPAL ;WARDLAW, SHARON L.

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Admission activity;Advisory Committees;Area;Budgets;career;career development;Cities;Clinical;Collaborations;college;Dedications;Diabetes Mellitus;Digestive System Disorders;Educational Curriculum;Endocrinology;expectation;Funding;Grant;improved;interest;International;Investigation;Journals;Kidney;Medical center;Medical Education;medical schools;Medical Students;Medicine;meetings;Mentors;National Institute of Diabetes and Digestive and Kidney Diseases;New York;Obesity;Outcome;Paper;Peer Review;Physicians;Process;programs;Publications;Publishing;Qualifying;Quantitative Reasoning;recruit;Research;Research Personnel;responsible research conduct;Running;scientific literacy;Students;Surgeon;Training;Training and Education;Training Programs;underrepresented minority student;Universities;Urology;Work

PROJECT_TITLE: Training Medical Students in NIDDK Research


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CHAPEL HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative  The current used X-ray medical imaging devices are not portable, too insensitive and may cause cancers to patient. We propose to develop metal halide perovskites-based X-ray detectors with strong signal, low noise, light weight, and foldable. They will be much more sensitive and convenient for trauma care applications.

PI_NAMEs: HUANG, JINSONG  (contact)

PROGRAM_OFFICER_NAME: TORNAI, MARTIN PAUL

PROJECT_TERMS: Address;Adhesives;Area;automobile accident;Cancer Etiology;Cancer Patient;cancer risk;Ceramics;Cerium;Characteristics;Charge;clinical diagnostics;cost;Data Collection;design;Detection;detector;Development;Devices;Diagnosis;Diagnostic Equipment;DNA Damage;Dose;Electrodes;Electronics;Electrons;Environment;Exposure to;fabrication;Film;flexibility;Generations;Glues;Hospitals;Image;imager;imaging detector;Imaging Device;imaging facilities;imaging modality;Imaging Techniques;improved;Individual;Injury;Ionizing radiation;Lead;light emission;light weight;Mammography;Mechanics;Medical Imaging;Membrane;Metals;Nature;Noise;Nylons;particle;Paste substance;Patient imaging;Patients;Pattern;perovskite;Play;point of care;Polymers;portability;Positioning Attribute;practical application;Process;radiation risk;Radiation-Induced Cancer;Research;Resolution;response;Roentgen Rays;Role;screening;Semiconductors;Signal Transduction;Silver;simulation;Solvents;Speed;Strontium;Structure;Techniques;Technology;tomosynthesis;trauma care;X-Ray Computed Tomography;X-Ray Medical Imaging;Yoga

PROJECT_TITLE: Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Fibromyalgia;Mental Health;Neurosciences;Pain Research

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: Narrative The patient-clinician interaction is central to most therapies and is supported by key interpersonal mechanisms of action, though the neural underpinnings of this effect are mostly unknown. As previous research has implicated brain-to-brain concordance of the temporoparietal junction, a region known to be intimately linked with theory of mind processing, we will use hyperscanning functional MRI to evaluate the impact of targeted theory of mind training in fibromyalgia patients on brain-to-brain concordance and how such training can synergistically couple with acupuncture therapy.

PI_NAMEs: EDWARDS, ROBERT R;NAPADOW, VITALY  (contact)

PROGRAM_OFFICER_NAME: QUINLAN, ERIN BURKE

PROJECT_TERMS: Absence of pain sensation;Acupuncture Analgesia;Acupuncture Therapy;Adopted;Attention;automated assessment;Behavioral;behavioral outcome;Brain;Chronic;chronic pain management;chronic pain patient;chronic painful condition;Clinical;clinical pain;Clinical Trials;Cognitive;cognitive function;Combined Modality Therapy;comparison control;Education;Educational Intervention;Electroacupuncture;Emotions;Empathy;experience;Experimental Models;Face;Facial Expression;Fibromyalgia;fibromyalgia pain;fibromyalgia patients;Functional Magnetic Resonance Imaging;Future;Image;improved;Institute of Medicine (U.S.);Interpersonal Relations;Intervention;Licensing;Link;Magnetic Resonance Imaging;Measures;Mediating;mental state;mentalization;multimodality;neural;neural model;neuroimaging;neurophysiology;Nonpharmacologic Therapy;novel;novel therapeutics;Outcome;Pain;Pain Disorder;Pain intensity;pain outcome;pain reduction;participant enrollment;Pathway interactions;Patient Self-Report;Patients;perspective taking;Protocols documentation;Provider;provider communication;psychosocial;Publishing;Quality of life;Questionnaires;Randomized;Recommendation;Reporting;Research;Research Design;Role;Severities;social;social communication;Social Functioning;Testing;theory of mind;Therapeutic;Training;Trust

PROJECT_TITLE: Impact of Theory of Mind Training on Brain-to-Brain Patient-Clinician Concordance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-RPHB-V(02)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Contraception/Reproduction;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project Narrative Recent studies suggest that increased inflammation in the female reproductive tract can predict an increased probability of HIV acquisition. Building on studies with non-human primates we will evaluate human tissue and mucus to gain insights into how the increased inflammation increase the chance of getting HIV infected.

PI_NAMEs: HOPE, THOMAS  (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Africa;African Women;AIDS prevention;AIDS Vaccines;Antibodies;Antibody Response;Antibody Specificity;Biological;Biological Assay;Cells;Cervical;Chicago;Clinical;Clinical Trials;cohort;Collection;Columnar Epithelium;Complex;Consensus;cytokine;Data;density;Depo Provera;design;Dose;Endocervix;Environment;Epidemiology;Epithelium;Epitopes;Equipment;Exocervix;female reproductive system;female reproductive tract;Functional disorder;Funding;Grant;Health;Healthcare;Heterosexuals;high risk;high risk population;HIV;HIV Antibodies;HIV Infections;HIV resistance;HIV vaccine;Hormonal;hormonal contraception;Hormones;Hospitals;Human;human female;human tissue;Hysterectomy;Image;Immunologics;Immunology;Individual;Infiltration;Inflammation;Inflammatory;inflammatory milieu;Injections;insight;Kenya;Laboratories;Letters;Location;Luteal Phase;Macaca mulatta;Male Circumcision;Medical;men;men who have sex with men;microbial;microbiome;Microscope;Modeling;Mucous body substance;Mucous Membrane;Natural History;nonhuman primate;novel strategies;Oral;Organ;pandemic disease;pathogen;Penetration;Phenotype;Physical Function;Physiology;Pilot Projects;Population;pre-exposure prophylaxis;Predisposition;prevent;Prevention approach;Prevention strategy;Probability;Production;Progestins;Prostitution;Publishing;recruit;Reporting;Resources;response;Role;Sampling;Science;Scientist;Series;Sexual Transmission;Sexually Transmitted Diseases;Squamous Epithelium;Surface;System;Testing;Time;tissue resource;Tissues;transmission process;Universities;USAID;vaccine development;vaccine trial;Vagina;Viral;Visit;Woman;women's prevention;Work

PROJECT_TITLE: Characterizing Mucosal Changes in the FRT Leading to Increased HIV Acquisition


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Despite the increasing clinical evidence of intracranial calcifications and craniosynostosis during prenatal ZIKV infection, yet the etiology remains an enigma and is currently unexplored. Herein, I seek to address the molecular mechanisms underlying ZIKV-induced calcifications and resulting craniofacial abnormalities. The insights gained will serve as a preclinical platform for development of therapeutic interventions.

PI_NAMEs: CHEN, WEIQIANG  (contact)

PROGRAM_OFFICER_NAME: CHOU, ALICIA YESIU

PROJECT_TERMS: Address;Affect;African;Americas;Asian;Blood Vessels;Bone Morphogenetic Proteins;Brain;brain cell;brain pericytes;brain tissue;calcification;Calcium;calcium phosphate;Calvaria;Cell Death Induction;Cell Physiology;cell type;Cells;Clinical;cohort;Collaborations;Congenital Abnormality;craniofacial;Craniofacial Abnormalities;craniofacial tissue;Craniosynostosis;cranium;Data;Defect;Deposition;Deterioration;Differentiated Gene;Disease Outbreaks;Etiology;Expression Library;fetal;Fetus;Future;Gene Expression;General Population;Genes;global health;Human;human fetal brain;human fetus tissue;imaging study;Immunocompetent;Immunohistochemistry;Implant;In Vitro;in vivo;Individual;Infection;innovation;insight;Joint structure of suture of skull;Knock-in;Knock-in Mouse;lentivirally transduced;Lentivirus Vector;Magnetic Resonance Imaging;Mass Spectrum Analysis;Mediating;Mesenchyme;Microcephaly;Molecular;mosquito-borne;Motor;Mus;mutant;Neurologic;Osteogenesis;osteogenic;Outcome;pathogen;Pathology;Peptide Hydrolases;Pericytes;Phase;Phenotype;Physiological;Play;pre-clinical;precursor cell;Pregnancy;premature;prenatal;Prevention strategy;Process;protein purification;Proteins;Public Health;pup;radiological imaging;Reporting;reverse genetics;Role;Seizures;Signal Pathway;Signal Transduction;Signaling Protein;single-cell RNA sequencing;soft tissue;Southeastern Asia;spastic paralysis;Specimen;Speech;stem cells;Surgical sutures;suture fusion;Technology;Testing;therapeutic development;Therapeutic Intervention;therapeutic target;transcription factor;Transforming Growth Factor beta;Uganda;Vector-transmitted infectious disease;Viral Genes;Viral Proteins;Virus;virus testing;Vision;Zika Virus;ZIKV infection

PROJECT_TITLE: Molecular regulatory mechanism of Zika virus-induced intracranial calcifications


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE: The kynurenine pathway (KP) is a conserved molecular pathway which consists of several bioactive metabolites that are detrimentally elevated with inflammation, aging and frailty in mammals. The goal of this study is to determine how suppression of KP metabolites affects functional decline, characteristics of aging, and lifespan in mice. In order to meet these goals, we will genetically and pharmacologically suppress specific components of the KP and measure functional decline, pathophysiological metabolic changes, lifespan and cellular changes associated with aging in mice.

PI_NAMEs: WESTBROOK, REYHAN M. (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Affect;Age;aged;Aging;aging related;Agonist;Amino Acids;anti aging;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Autophagocytosis;C57BL/6 Mouse;Caenorhabditis elegans;Cells;Characteristics;Chronic;Coenzymes;cytokine;cytotoxic;Data;dietary;Dioxygenases;Drosophila genus;Electrons;enzyme pathway;Epidemiology;extend lifespan;Family;Frail Elderly;frailty;Free Radicals;functional decline;Genetic;Genetic Engineering;Goals;healthspan;Human;Immune;Immunosuppression;Impairment;improved;indolamine;Inflammation;Inflammatory;Intervention;Knock-out;Knockout Mice;Kynurenic Acid;Kynurenine;Kynurenine 3-monooxygenase;Lead;life span;Link;Mammals;Measures;Mediator;Metabolic;methyl tryptophan;Molecular;mortality;Mus;Nerve Degeneration;Niacinamide;old mice;older adult;Organism;Oxidative Stress Induction;Pathologic;Pathway interactions;pharmacologic;Phenotype;Physical Function;Physiological;Play;preservation;Process;Production;Property;Publishing;quinolinate;Quinolinic Acid;Rodent;Role;sarcopenia;senescence;Serum;Signal Transduction;Supplementation;synergism;Testing;Text;Therapeutic;Tissues;translational study;Tryptophan;Vertebrates

PROJECT_TITLE: Effects of Genetic and Pharmacological Kynurenine Pathway Suppression on Healthspan, Lifespan, and Cellular Changes Associated with Aging in Mice

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: This is a request to fund a training program combining basic neuroscientists and clinicians hoping to gain a fuller foundation in neurobiology. The interactive environment allows these basic neuroscientists and their clinical counterparts to train together so that they appreciate the bidirectional nature of translational neuroscience. This program creates neuroscientists with an understanding of psychiatry and psychiatric scientists with a good feel for the neuroscience that underlies disorders of cognition and mood.

PI_NAMEs: RASENICK, MARK M. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Mental Health;Neurosciences;Training

PROJECT_TITLE: Training in the Neuroscience of Mental Health


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Health Services;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE  Over-screening for breast cancer occurs frequently in older women with limited life expectancies even though it may inappropriately subject them to short-term harms with little chance of benefit. Clinician-patient communication holds promise to reduce over-screening in older women but its impact may be weakened by conflicting messages from other sources. This proposal aims to better understand the impact of messages from different sources on older women's screening intentions in order to inform a communication intervention, as next step, to reduce breast cancer over-screening among older women.

PI_NAMEs: SCHOENBORN, NANCY  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Administrator;Advocacy;Age;American Cancer Society;Anecdotes;Attitude;Behavior;Belief;Breast Cancer Detection;Caregivers;Clinical;Clinical Treatment;Communication;Communities;Data;Diagnosis;Early Diagnosis;experience;experimental study;Family;Family member;Focus Groups;Friends;Goals;Guidelines;Health;Health system;high risk;human old age (65+);Incidence;innovation;Intervention;Knowledge;Life;Life Expectancy;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic screening;Morbidity - disease rate;mortality;multidisciplinary;news;novel;Odds Ratio;older adult;older patient;older women;overtreatment;patient screening;patient-clinician communication;Patients;Randomized;Recommendation;Reporting;Research;routine screening;screening;Screening for cancer;screening guidelines;Social Network;social relationships;Source;Surveys;Time;Trust;Vacuum;Woman;Work;young woman

PROJECT_TITLE: Messaging Strategies to Reduce Breast Cancer Over-Screening in Older Women

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Brain Disorders;Clinical Research;Infectious Diseases;Neurosciences;Rare Diseases

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE Neuroinflammatory diseases collectively cause significant morbidity and mortality, and a major roadblock to their effective diagnosis and treatment continues to be poor understanding about the underlying infectious or autoimmune etiologies in a large proportion of cases. This multi-center study combines incredibly deep clinical phenotyping capabilities with the most advanced molecular biology and bioinformatic tools to identify novel infectious and autoimmune causes of neuroinflammatory disease and better understand pathogenesis.

PI_NAMEs: MISHRA, NISCHAY ;NATH, AVINDRA ;WILSON, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Admission activity;Affect;Antibodies;antibody detection;antibody test;Antigens;antimicrobial;Autoantibodies;Autoantigens;Autoimmune;Autoimmune Diseases;B-Lymphocytes;Bacteria;Bioinformatics;bioinformatics tool;Biological Assay;Biological Markers;Biological Products;career;Cells;Central Nervous System;Central Nervous System Infections;Cerebrospinal Fluid;cerebrospinal fluid flow;Chronic;Classification;Clinical;clinical center;clinical phenotype;collaborative approach;Communicable Diseases;Communities;Complex;Dangerousness;Databases;Dedications;detection assay;detection method;Development;Diagnosis;Diagnostic;Disease;disease classification;disease diagnostic;Emerging infection;Encephalitis;Etiology;Evaluation;Extramural Activities;Failure;Fc Receptor;Flow Cytometry;Functional disorder;fungus;genome sequencing;Government;Health care facility;Hospitalization;Human;Image;Immune;Immune response;Immunoprecipitation;Immunosuppressive Agents;In Vitro;Individual;individual patient;Inflammatory;Institution;Investigation;Knockout Mice;Laboratories;Lead;Libraries;Lymphocyte;Malignant Neoplasms;Mass Spectrum Analysis;Medical center;Memory;Meningitis;Metagenomics;Methodology;microbial;Modeling;Molecular Biology;Morbidity - disease rate;mortality;MRI Scans;Multicenter Studies;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;neural;neuroimmunologic disease;neuroinflammation;Neurologist;Neurology;next generation sequencing;novel;nucleic acid detection;Nucleic Acids;Parasites;participant enrollment;pathogen;Pathogen detection;Pathogenesis;patient screening;Patients;Pattern;Persons;Phage Display;Phage ImmunoPrecipitation Sequencing;Physicians;Population Surveillance;predictive modeling;programmed cell death protein 1;programs;Progressive Multifocal Leukoencephalopathy;Proteome;Protocols documentation;Psychoses;rare genetic disorder;Recording of previous events;Reporting;Research;Scientist;Seizures;Services;Stains;Structure;Syndrome;T cell clonality;T cell receptor repertoire sequencing;T Chain;T-Lymphocyte;targeted treatment;Techniques;tertiary care;Testing;Time;Tissue Stains;tool;United States National Institutes of Health;Universities;Vertebrate Viruses;Viral;virome;Virus;Washington;whole genome;Yeasts

PROJECT_TITLE: Investigation and Treatment of Undiagnosed Neuroinflammatory Diseases


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Brain Disorders;Disability Research;Epilepsy;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Narrative: There are over 2 million annual cases of traumatic brain injury contributing to debilitating sequelae such as epilepsy and cognitive disability emphasizing the need to identify mechanisms and therapies. Studies proposed here will test a novel molecular pathway involving immune receptor mediated activation of a specific endopeptidase as a mechanisms for abnormal birth, integration, and function of neurons in the dentate gyrus after brain injury. The experiments will test whether circuit changes after trauma impair brain rhythms involved in memory processing and examine the therapeutic potential of posttraumatic inhibition of the endopeptidase in preventing epilepsy and memory deficits after brain injury.

PI_NAMEs: SANTHAKUMAR, VIJAYALAKSHMI  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acceleration;Address;Adult;adult neurogenesis;adverse outcome;Affect;American;Animals;antagonist;Award;Behavioral Assay;Biochemical;Biological Assay;Birth;brain dysfunction;Brain Injuries;Cell Culture Techniques;cell motility;Cells;cognitive disability;Communication;Control Animal;Coupling;Data;dentate gyrus;Development;disability;disability burden;Early Intervention;Economic Burden;Electroencephalography;Endopeptidases;entorhinal cortex;Epilepsy;Epileptogenesis;Equilibrium;Event;experimental study;Feedback;fluid percussion injury;Frequencies;Functional disorder;Gelatinase B;Genetic;genetic approach;granule cell;healthcare burden;Hippocampus;Histologic;Histology;immune function;Immunologic Receptors;improved;In Situ;in vivo;Injury;Link;Mediating;Memory;memory consolidation;Memory impairment;Memory Loss;memory process;migration;Mission;Modeling;Molecular;Mus;National Institute of Neurological Disorders and Stroke;neocortical;Nervous System Disorder;neurochemistry;neurogenesis;Neurologic Dysfunctions;Neuronal Plasticity;Neurons;neuropathology;neurophysiology;novel;Parahippocampal Gyrus;Pathologic;Pathway interactions;Patients;Pharmacology;physically handicapped;Physiological;Physiology;Pilot Projects;post stroke;Predisposition;prevent;Prevention strategy;Publishing;Quality of life;Regulation;Reporter;Role;Seizures;Signal Transduction;Source;Stroke;Structure;Synapses;Synaptic plasticity;Techniques;Testing;Therapeutic;timeline;TLR4 gene;Transgenic Mice;Trauma;Traumatic Brain Injury

PROJECT_TITLE: Contribution of Innate Immune Receptors to Neurological Dysfunction After Traumatic Brain Injury: Mechanisms and Therapeutic Implications

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: NARRATIVE Fever is one of the most common reasons for care-seeking in Thailand, but most causes of fever are never identified. Understanding the burden of what causes fever is vital to design appropriate and targeted public health interventions and reduce disease burden. Here we evaluate methods to efficiently measure the population-level burden of scrub typhus, melioidosis, and typhoid fever from blood antibody levels.

PI_NAMEs: AIEMJOY, KRISTEN  (contact)

PROGRAM_OFFICER_NAME: JESSUP, CHRISTINE

PROJECT_TERMS: Acute;Address;Age;age related;analytical method;Antibodies;Antibody Response;Bayesian Modeling;Blood;burden of illness;care seeking;Child;Clinical;Communicable Diseases;Complex;computerized tools;Coupled;Cross-Sectional Studies;Data;Data Set;Data Sources;Dependence;design;Development;Diagnosis;Diagnostic;Disease;Enrollment;Epidemiologic Methods;Epidemiology;Etiology;evidence base;experience;Fever;Geography;global health;Goals;Health Professional;Health Sciences;high dimensionality;Immunology;Incidence;India;Infection;Infectious Diseases Research;innovation;Institution;International;international partnership;Intervention;Kinetics;Knowledge;Leadership;Longitudinal cohort study;Machine Learning;mathematical model;Measures;Melioidosis;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;pathogen;Performance;Persons;Population;population based;Prevention strategy;professor;programs;prospective;Province;Public Health;public health intervention;public health priorities;Recording of previous events;Reporting;Research;Research Priority;Research Support;Resources;response;Sampling;Schools;Scientist;Scrub Typhus;Selection Bias;seroconversion;serological marker;Serology;Seroprevalences;serosurvey;Serum;sex;Shapes;simulation;skill acquisition;skills;Symptoms;Thailand;Time;tool;Training;Translating;transmission process;treatment strategy;Typhoid Fever;Undifferentiated;Universities

PROJECT_TITLE: Estimating the Seroincidence of Melioidosis, Typhoid Fever and Scrub Typhus from Cross-sectional Serosurveys

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE About 40% of prescribed drugs target G protein-coupled receptors (GPCRs), which activate transducer proteins called G proteins and arrestins to produce effects that can be either beneficial or detrimental to human health. It is not known how GPCRs select the correct transducers needed to produce appropriate cellular or therapeutic responses, or how the cellular context affects this molecular mechanism. This project aims to increase understanding of how GPCRs interact with their transducers to produce coordinated cellular signals, and may facilitate the development of drugs with the capacity to fine-tune cell signaling and better treat disease.

PI_NAMEs: LAMBERT, NEVIN ALAN (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Affect;Arrestins;Cell membrane;Cell model;Coupling;Disease;drug development;Drug Prescriptions;Drug Targeting;Family;FDA approved;G-Protein-Coupled Receptors;GTP-Binding Proteins;Health;Heterotrimeric GTP-Binding Proteins;Hormones;Human;in vivo;Ligand Binding;Maps;Modeling;Molecular;Molecular Conformation;Neurotransmitters;overexpression;Pharmaceutical Preparations;Pharmacology;Physiological;Physiology;Prevalence;Proteins;receptor;receptor binding;Receptor Signaling;receptor-mediated signaling;Signal Transduction;Signaling Protein;stoichiometry;Transducers;Translating;treatment response

PROJECT_TITLE: Conventional and unconventional GPCR-G protein coupling

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pancreatic Cancer;Patient Safety;Prevention;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Unlike other common cancers for which early detection and surgical resection have reduced cancer deaths (e.g. colon polyps for colon cancer, ductal carcinoma in situ lesions and breast cancer), pancreas cancer precursors, such as commonly observed pancreatic cysts, are poorly understood. Towards the long-term goal of early detection of pancreatic cancer, our objective in this proposal is to accurately detect and characterize pancreatic cysts before they turn into aggressive cancer. The outcome of this research will be a new diagnostic tool, named Cyst-X, which will establish a better clinical strategy than the current guidelines by recommending a more selective use of invasive testing, surgery, and surveillance.

PI_NAMEs: BAGCI, ULAS  (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Academic Medical Centers;Algorithms;Artificial Intelligence;artificial intelligence model;automated algorithm;Biopsy;Cancer Etiology;cancer invasiveness;cancer type;capsule;Cessation of life;Characteristics;Clinic;Clinical;clinical center;clinical decision-making;Colon Carcinoma;Colonic Polyps;cost;Cyst;Cystic Neoplasm;Data;Data Set;deep learning;deep learning algorithm;design;Detection;detection method;detection platform;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Disease;Early Diagnosis;efficacy validation;Epithelial cyst;European;Evaluation;Excision;experimental study;follow-up;Goals;Guidelines;High Prevalence;high risk;Histopathology;Image;improved;In Situ Lesion;Individual;International;Lesion;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Medical center;Methods;Modeling;Morbidity - disease rate;mortality;MRI Scans;Mucinous Cystadenoma;Mucinous Neoplasm;Multicenter Studies;Names;Noninfiltrating Intraductal Carcinoma;novel diagnostics;Operative Surgical Procedures;Organ;Outcome;Outcomes Research;Pancreas;Pancreatectomy;Pancreatic Cyst;Pancreatic cystic neoplasia;pancreatic neoplasm;Papillary;Patient Triage;Patient-Focused Outcomes;Patients;Performance;premalignant;Prognosis;prognostic significance;Property;radiological imaging;radiologist;Radiology Specialty;radiomics;Recommendation;Reference Standards;Research;Risk;risk stratification;Scanning;screening;Sensitivity and Specificity;Series;Serous Cystadenoma;Side;stem;Structure;Surveillance Program;Survival Rate;System;Technology;Testing;Time;tool;Trust;United States;Universities;Unnecessary Surgery;Visual

PROJECT_TITLE: Cyst-X: Interpretable Deep Learning Based Risk Stratification of Pancreatic Cystic Tumors

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: Program Director/Principal Investigator (Last, First, Middle): Ruglass, Lesia, M. PROJECT NARRATIVE Significant disparities in the number of underrepresented racial/ethnic minority (URM) scientists successfully receiving awards for independent funding (i.e., NIH, NSF, etc.) continue to plague scientific research despite many years of efforts to improve such disparities. This proposed research training program, "Translational research training in addictions for racial/ethnic minorities at City College of New York (CCNY), Columbia University Medical Center (CUMC), and Rutgers University (RU) or TRACC-RU," aims to increase the number of interdisciplinary scientists capable to serve as Principal Investigators (PIs) on extramurally funded studies in drug abuse research from URM groups, which will improve public health. OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

PI_NAMEs: HIEN, DENISE AIMEE;RUGLASS, LESIA MONIQUE (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: Academic Medical Centers;addiction;Address;Animal Model;Animals;Applications Grants;Applied Research;Area;Award;Basic Science;career;career development;Cities;Clinical;Clinical Treatment;Clinical Trials Network;cognitive neuroscience;Collaborations;college;Communities;community intervention;Competence;Dedications;design;Development;Discipline;Disparity;Doctor of Philosophy;Drug abuse;educational atmosphere;Educational Curriculum;effectiveness/implementation trial;ethnic minority;ethnic minority population;Event;evidence base;Exposure to;Extramural Activities;Faculty;Funding;Funding Mechanisms;Future;Goals;graduate student;Grant;Human;human model;Hybrids;improved;innovation;Institution;interest;Joints;journal article;Knowledge;laboratory experience;Legal;marijuana use disorder;medical schools;Mentors;Mentorship;Methodology;Methods;minority scientist;minority student;Minority-Serving Institution;Modeling;Multi-Institutional Clinical Trial;National Institute of Drug Abuse;Neurosciences Research;New Jersey;New York;opioid use disorder;Outcome;Paper;peer;Persons;posters;pre-doctoral;Prevention;Principal Investigator;programs;Psychiatry;Psychology;Public Health;Publications;Qualifying;racial minority;recruit;Research;Research Personnel;Research Project Grants;Research Training;Resources;role model;Science;Scientist;Self Efficacy;Site;skill acquisition;Social Sciences;Structure;Students;Substance abuse problem;Substance Use Disorder;symposium;Talents;Training;Training Activity;Training Programs;translational neuroscience;Translational Research;translational research program;treatment trial;undergraduate student;United States National Institutes of Health;Universities

PROJECT_TITLE: Translational Research Training on Addictions for Racial/Ethnic Minorities


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SAN JUAN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PUERTO RICO MED SCIENCES

ORG_STATE: PR

PHR: PROJECT NARRATIVE We will validate one molecular pathway contributing to the cisplatin resistance of ovarian cancer cells, Matrix Metalloproteinase 3 (MMP3), as a potential therapeutic target. In addition, we will identify MMP3-associated molecules that hold therapeutic potential. Therefore, this research project is highly relevant to the public health because the discovery of novel targets for intervention will impact 50-70% of ovarian cancer patients, mainly those who become resistant to cisplatin treatment.

PI_NAMEs: VIVAS-MEJIA, PABLO ELIAS (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Agreement;angiogenesis;Applications Grants;Binding;Biological;Biomedical Research;cancer cell;Cancer Etiology;Cancer Model;Cancer Patient;cancer therapy;Cancerous;carcinogenesis;Catalytic Domain;Cell Extracts;Cell Physiology;Cell Proliferation;Cell Survival;Cells;Cessation of life;Chemicals;Chemoresistance;chemotherapy;Cisplatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Conditioned Culture Media;Data;data portal;design;Disease;Disease Progression;Dose;effective therapy;Enzymes;experimental study;Extracellular Matrix;Family;Genes;Goals;graduate student;Hemopexin;holistic approach;Immunoprecipitation;Implant;in vivo;inhibitor;Intervention;intraperitoneal;Investigation;knock-down;Knock-out;Laboratories;Link;Liposomes;Malignant neoplasm of ovary;Malignant Neoplasms;Mass Spectrum Analysis;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Medical;Messenger RNA;Mission;Molecular;Molecular Biology;mouse model;mutant;Neoplasm Metastasis;new therapeutic target;Nodule;novel;novel therapeutic intervention;Nude Mice;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Platinum;Play;Predisposition;Process;programs;Progression-Free Survivals;Proliferating;protein structure;Proteins;Proteomics;Public Health;Publishing;Puerto Rico;Quinones;Regulation;Relapse;Research;Research Project Grants;Resistance;response;RNA;RNA Interference;Role;Science;Seminal;Signaling Protein;Small Interfering RNA;Stromelysin 1;subcutaneous;taxane;Testing;The Cancer Genome Atlas;Therapeutic;Therapeutic Effect;therapeutic target;therapy resistant;Tissue-Specific Gene Expression;tool;Toxic effect;transcriptome sequencing;Transfection;trend;tumor;Tumor Cell Invasion;tumor growth;Tumor Weights;undergraduate student;university student;Western Blotting;Woman

PROJECT_TITLE: Unraveling the Role of MMP3 in the Cisplatin Resistance of Ovarian Cancer


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative The proposed work will determine that endogenous GABA signaling in the islet is a key paracrine modulator of delta cell function as a signaling hub. It will demonstrate that the delta cell and somatostatin play important roles as immunomodulators in their interaction with the local sensory nerves and immune cells, thus protecting the islet from damaging inflammation. As a major expected outcome, we will prove that delta cell, as a master regulator of 1) endocrine function, 2) local immune responses and 3) sensory nerve excitability, is essential for islet homeostasis.

PI_NAMEs: RODRIGUEZ-DIAZ, RAYNER  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Address;Affect;afferent nerve;Afferent Neurons;Alpha Cell;Back;Beta Cell;Biology;Cell Physiology;cell type;Cells;Chronic;Communication;cytokine;D Cells;Data;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;diphtheria toxin receptor;Electrophysiology (science);Elements;Endocrine;Endocrine Glands;Feedback;Feeds;Functional Imaging;gamma-Aminobutyric Acid;Glucagon;Glucose;glucose metabolism;Goals;high body mass index;Homeostasis;Hormone Antagonists;Hormone secretion;Human;Immune;Immune response;Immune signaling;Immune system;Immunomodulators;In Vitro;in vivo;Individual;Infiltration;Inflammation;Inflammatory;Insulin;insulin secretion;islet;Islet Cell;Islets of Langerhans;Mediating;Membrane Potentials;Metabolic;Modeling;mouse model;Mus;Natural History;nerve supply;Nervous System;neural;neuroinflammation;Neurons;Neuropeptides;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;optogenetics;Outcome;Pancreas;Pancreatic delta Cell;paracrine;Paracrine Communication;Peptides;pharmacologic;Pilot Projects;Play;Positioning Attribute;Predisposition;recruit;Regulation;Research;response;restraint;Role;Signal Transduction;Slice;Somatostatin;Sorting;Source;Stimulus;Substance P;System;Testing;Tissues;tool;Work

PROJECT_TITLE: The delta cell as a key regulator of pancreatic islet biology