ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Cytosolic detection of viral nucleic acids elicits the activation of type I interferon (IFN-I) cytokines to foster an antiviral state. While a non-canonical NF-ĸB signaling pathway plays key roles in lymphoid organogenesis and B-cell homeostasis upon extracellular ligation by TNF receptor superfamily members, we unexpectedly found that intracellular cytosolic sensing of viral nucleic acids also triggers the non-canonical NF-ĸB pathway. The proposed research utilizes published data sets to identify and characterize a novel regulator of a key signaling component that coordinates cross-talk events between these two disparate pathways.

PI_NAMEs: PARVATIYAR, KISLAY  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Age of Onset;age related;age-related disease;autoinflammatory;autoinflammatory diseases;B-Lymphocytes;Cell Maintenance;Cell Survival;Cells;Chromosomal Instability;combat;Complex;cytokine;Data;Data Set;Development;Disease;Disparate;DNA;DNA Damage;Event;extracellular;Fostering;Germ Lines;Goals;Homeostasis;Host Defense;Immune;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;Interferon Activation;Interferon Type I;Licensing;Ligation;Link;liquid chromatography mass spectrometry;Lymphoid;member;Natural Immunity;Nervous System Disorder;novel;novel therapeutics;nucleic acid detection;Nucleic Acids;Organogenesis;Pathway interactions;Pattern recognition receptor;Phosphotransferases;Play;prediction algorithm;programs;Protein Kinase Interaction;Proteins;Publications;Publishing;Regulation;Regulatory Element;Research;response;RNA;Role;Signal Pathway;Signal Transduction;Sterility;Synaptosomes;Testing;therapeutic target;TNF receptor-associated factor 3;transcription factor;Tumor Necrosis Factor Receptor;Viral;viral detection;Viral Genes;Viral Genome;Virus Diseases;Virus Replication

PROJECT_TITLE: TRAF3 regulation in antiviral host defense

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-M(90)]


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NUTRITION

ORG_FIPS: US

ORG_NAME: TUFTS UNIVERSITY BOSTON

ORG_STATE: MA

PHR: NARRATIVE Type 2 Diabetes (T2D) is one of the most prevalent and fastest-growing causes of disability, lost productivity, mortality, and health-care costs in the US and disproportionately afflicts ethnic minorities and particularly Puerto Ricans (PR). Recent evidence suggests that social stressors and/or protective factors may affect health via epigenomic modifications. Delineating mechanisms by which identified DNA methylation modifications and associated pathways relate to T2D risk will support the development of innovative strategies in public health to cope with environmental and social stressors and subsequently prevent T2D and related health disparities in vulnerable populations.

PI_NAMEs: ORDOVAS, JOSE M. (contact)

PROGRAM_OFFICER_NAME: LAI, GABRIEL Y

PROJECT_TERMS: Accounting;adequate sleep;Adult;Adverse event;Affect;Age;age acceleration;Automobile Driving;Behavior;Behavioral;Biological;Biological Markers;Biology;Blood specimen;Boston;Characteristics;Childhood;Chronic Disease;Chronology;cohort;Communities;coping;Cross-Sectional Studies;Data;Development;diabetes risk;Diet;disability;Discrimination;Disparity;DNA;DNA Methylation;Environment;Environmental Exposure;environmental stressor;Epigenetic Process;epigenomics;ethnic minority;Event;Exposure to;Family member;family support;follow-up;Gene Expression;Genes;genome-wide;Glucose;Glycosylated hemoglobin A;Goals;good diet;Health;Health Care Costs;health disparity;Health Status;high risk;Hispanic Populations;Incidence;Individual;innovation;Island;Knowledge;Life;Location;longitudinal analysis;Massachusetts;Measures;Mediator;Metabolic;metabolic profile;methylome;migration;Minority Groups;Modification;mortality;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Observational Study;Participant;Pathway interactions;Physical activity;Physiological;Populations at Risk;Prevalence;prevent;Productivity;protective factors;Psychosocial Assessment and Care;Public Health;Puerto Rican;Puerto Rico;recruit;Research;resilience;Resources;response;Risk;Sampling;social;social culture;social disparities;Social Environment;social factors;social stressor;Social support;Standardization;stressor;Testing;Time;trend;Underrepresented Minority;Unhealthy Diet;unhealthy lifestyle;United States;Variant;Visit;Vulnerable Populations

PROJECT_TITLE: Social Stressors, Epigenetics and Health Status in Underrepresented minorities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-G(55)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Climate-Related Exposures and Conditions;Genetics;Lupus

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Exposure to UV irradiation can lead to inflammation in the skin and cause disease flares in patients with cutaneous SLE. We have found that expression of a FOXP3 isoform lacking sequences in exon 2 (FOXP3∆Ex2) is increased in SLE. We have generated an animal model lacking this exon of Foxp3 and have found that these animals increased skin inflammation following UV exposure. This model will provide important insights into the mechanism of inflammatory skin disease and open up novel pathways for therapeutic intervention.

PI_NAMEs: ZIEGLER, STEVEN F (contact)

PROJECT_TERMS: Age;Alternative Splicing;Amino Acid Sequence;Animal Model;Animals;Antibodies;Antigens;Antinuclear Antibodies;Atmosphere;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactivity;Basophils;Binding;Bone Marrow;Carcinogen exposure;Cells;Chimera organism;Complex;Cutaneous;Data;Deposition;Development;Disease;DNA;Exons;Exposure to;Flare;FOXP3 gene;Frequencies;Gene Structure;Geographic Locations;Homeostasis;Human;IgE;Immune response;Immune system;Immunodysregulation polyendocrinopathy enteropathy X-linked syndrome;immunoregulation;Infiltration;Inflammation;Inflammatory;insight;irradiation;Keratin;keratinocyte;Kidney;Length;Light;light intensity;Lupus;Mediating;Mixed Connective Tissue Disease;Modeling;Mouse Strains;Mus;Mutation;novel;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Phototoxic Dermatitis;Play;Production;Protein Isoforms;Regulatory T-Lymphocyte;response;Role;Skin;skin disorder;Structure of germinal center of lymph node;Systemic Lupus Erythematosus;Testing;Therapeutic Intervention;TNFSF5 gene;Ultraviolet B Radiation;ultraviolet irradiation;UV Radiation Exposure;UVB induced;Work

PROJECT_TITLE: Foxp3 isoforms and IgE-mediated UVB-induced skin inflammation expression

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: TALLAHASSEE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Influenza viruses remain a global health concern due to yearly epidemics and their pandemic potential, therefore, understanding immunity to these viruses and further research on the development of improved vaccines is of high importance. The anchor epitope is a recently discovered region of the H1N1 influenza HA protein that elicits broadly neutralizing antibodies. In this proposal, we will computationally design scaffolded anchor proteins and test their immunogenicity and efficacy in animal models of influenza infection.

PI_NAMEs: MOUSA, JARROD  (contact);STRAUCH, EVA-MARIA

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: Animal Model;anti-influenza;Antibodies;Antibody Response;B-Lymphocytes;Binding;Classification;cross reactivity;design;Development;DNA-Directed RNA Polymerase;efficacy evaluation;Epidemic;Epitopes;Event;Experimental Designs;global health;Glycoproteins;Goals;Head;Hemagglutinin;high reward;high risk;human subject;Immune;Immune response;Immunity;immunogenicity;Immunology;improved;Infection;Influenza;Influenza A Virus, H1N1 Subtype;Influenza Hemagglutinin;influenza infection;influenza virus vaccine;influenzavirus;innovation;Machine Learning;machine learning method;Membrane;Modeling;monomer;mouse model;Mus;Mutation;Network-based;neural network;Neuraminidase;neutralizing antibody;novel;novel strategies;pandemic potential;pandemic virus;pathogen;Prevalence;Property;Protein Engineering;Proteins;Rapid screening;Recombinants;Regimen;Research;Research Personnel;response;scaffold;Site;stem;Surface;Technology;Testing;tool;Vaccinated;Vaccination;vaccine candidate;vaccine efficacy;Vaccines;Viral;Virus;Work;Zoonoses

PROJECT_TITLE: Computationally designed anchor scaffolds for elicitation of broadly neutralizing influenza antibodies

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Mutations in DNMT3A and TET2 genes are common in the immune cells of elderly individuals and increase the risk for age-related comorbidities such as severe infections and cardiovascular disease. Efforts to identify factors that can be targeted to mitigate the pathogenic consequences of DNMT3A and TET2 mutations are hampered by their complex effects, which involve chemical modification of genomic DNA that subsequently affects gene expression and immune responses. To unravel this complexity, our study combines two state-of-the-art engineering approaches: (1) genetically engineered human immune cells and (2) mathematical modeling of gene regulatory networks.

PI_NAMEs: BYUN, MINJI ;MIRALDI, EMILY  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adult;Affect;Age related comorbidities;age-related disease;Animals;ATAC-seq;Atherosclerosis;Automobile Driving;Awareness;Bacterial Infections;Binding;Binding Sites;Cardiovascular Diseases;Cell Differentiation process;Cell Physiology;cell type;Cells;Chemicals;ChIP-seq;Chromatin;Chronic Kidney Failure;Communities;Complex;Computer Models;Data;data resource;Data Set;Death Rate;deep neural network;Defect;Disease;disease model;disorder risk;DNA;DNA Methylation;DNA Methylation Regulation;DNA-Directed RNA Polymerase;DNMT3a;Elderly;Engineering;Enhancers;Enzymes;Future;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Engineering;Genetic Risk;Genetic Transcription;genome-wide;Genomic DNA;Genomics;Hematologic Neoplasms;Hematopoietic;Human;human disease;Human Engineering;human old age (65+);human pluripotent stem cell;Immune;immune activation;Immune response;Immune System Diseases;Impairment;improved;in silico;Individual;Infection;interest;Investigation;knock-down;Link;Macrophage;mathematical model;Mediating;Methodology;Methods;Methylation;methylation pattern;Modeling;Modification;Molecular;mortality;Mutate;Mutation;network models;Neural Network Simulation;novel;Osteoporosis;Pathogenicity;Pathway interactions;Pattern;Phenotype;Reader;recruit;Resources;response;Risk;risk variant;Site;Somatic Mutation;Stimulus;Testing;therapeutic target;Tissue-Specific Gene Expression;training data;trait;transcription factor;user-friendly;Virus Diseases

PROJECT_TITLE: Gene regulatory network modeling of disease-associated DNA methylation perturbations

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Membrane trafficking of receptors is crucial for synaptic activity. This proposal will further test the hypothesis that a newly discovered trafficking pathway in non-neuronal cells, is also critical in neurons. In addition, this proposal will determine whether this new pathway is coordinated with a previously discovered pathway.

PI_NAMEs: SUTTON, MICHAEL MARK ALEXANDER;WEISMAN, LOIS S (contact)

PROGRAM_OFFICER_NAME: MATOS GALICIA, HEIDI YANICE

PROJECT_TERMS: Address;Brain;Complex;Data;Defect;Dendritic Spines;density;Dorsal;Down-Regulation;Endosomes;Excitatory Synapse;Frequencies;genetic regulatory protein;Glutamate Receptor;Hippocampus;Immunofluorescence Microscopy;Inhibitory Synapse;inorganic phosphate;insight;Integrins;knock-down;Lentivirus;Lipids;Long-Term Depression;Maintenance;Measures;Membrane;Minor;Molecular;Mutation;Nervous System;Nervous System Disorder;Neuroglia;Neurons;Pathway interactions;phosphatidylinositol 5-phosphate;Phosphatidylinositols;PI3 gene;Play;postsynaptic;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Rattus;receptor;receptor recycling;recruit;Recruitment Activity;Recycling;Regulation;Role;Signal Transduction;Site;Slice;small hairpin RNA;Surface;Synapses;synaptic function;Synaptic plasticity;Testing;trafficking;Vertebral column

PROJECT_TITLE: Regulation of parallel recycling pathways at synaptic sites

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Fecal microbiota transplantation (FMT) is an effective microbiome-manipulation based therapeutic for the treatment of recurrent Clostridioides difficile infection (rCDI). However, due to its undefined composition and dependency on human produced fecal samples for each transplant, FMT presents challenges with its scalability and with determining its safety profile. To accelerate the transition from fecal transplants to defined cocktails of bacteria (i.e., live biotherapeutic products; LBP), we will compare FMT with LBP for the treatment of rCDI.

PI_NAMEs: FAITH, JEREMIAH JAMES (contact);GRINSPAN , ARI

PROGRAM_OFFICER_NAME: LUNSFORD, DWAYNE

PROJECT_TERMS: Acceleration;active comparator;Adverse event;Aftercare;Antibiotics;antimicrobial;Bacteria;Basic Science;biobank;Biological Response Modifier Therapy;Cessation of life;Clinical;clinical application;clinical care;Clinical Trials;Clostridium difficile;Collection;Communities;comparative efficacy;Complex;cost effective;Coupled;Data;density;Dependence;design;Diarrhea;Donor person;Engraftment;enteropathogenic Escherichia coli;Escherichia coli;Escherichia coli EHEC;Extended-spectrum β-lactamase;fecal transplantation;Feces;fitness;Freezing;gut microbes;gut microbiota;Healthcare;Human;improved;In Vitro;in vitro Model;in vivo;Individual;individual response;Infection;insight;Investigation;Laboratories;manufacture;manufacturing process;microbial;microbiome;mortality risk;novel therapeutics;open label;opportunistic pathogen;Oral;Organism;pathogen;Patients;Pharmaceutical Preparations;Process;programs;Randomized;Randomized, Controlled Trials;Recurrence;Relapse;relapse prediction;relapse prevention;Reporting;response;restoration;Risk;Route;Safety;SARS-CoV-2 transmission;Selection Criteria;Serious Adverse Event;Single-Blind Study;Source;stool sample;success;Therapeutic;Translations;transmission process;Transplant Recipients;Transplantation;transplantation therapy;Ulcerative Colitis;Vancomycin;viral transmission

PROJECT_TITLE: Comparison of defined live biotherapeutic product and fecal microbiota transplantation for treatment of recurrent Clostridioides difficile infection

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Chicago

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Central retinal artery occlusion is an acute emergency that results in retinal cell death via a number of mechanisms. Preventing retinal cells from dying is a major public health necessity. Our objective is to study mesenchymal stem cell secreted extracellular vesicles (EVs) as a therapeutic tool to prevent the loss of vision from central retinal artery occlusion, wherein we plan to develop functionally engineered EVs (FEEs) for retina- specific protective actions.

PI_NAMEs: RAVINDRAN, SRIRAM ;ROTH, STEVEN  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Acute;Address;Adjuvant;Affect;Alteplase;Animal Model;antagonist;anterior chamber;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Apoptotic;Attenuated;Basic Science;Biology;Biomimetics;Blindness;Blood-Retinal Barrier;Cardiac Surgery procedures;Case Series;Cell Death;cell injury;Cell secretion;Cells;Central Retinal Artery Occlusion;cerebrovascular;Characteristics;clinical translation;combat;Cytokine Gene;Cytoprotection;Dermal;Diabetic Retinopathy;disability burden;Disease;Economic Burden;effectiveness evaluation;Elderly;Emergency Situation;Engineering;Enrollment;Event;experimental study;extracellular vesicles;Eye;Face;falls;Filler;Functional dependence;Functional impairment;functional mimics;gain of function;Generations;Growth;human disease;human model;Hyperbaric Oxygen;Hypoxia;Iatrogenesis;Immune response;immunoregulation;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Injections;innovation;Interruption;Intervention;Intravenous;Ischemia;ischemic injury;knock-down;Knowledge;Laboratories;Long-Term Care;loss of function;Massage;Mediating;Mesenchymal Stem Cells;Methodology;Microglia;MicroRNAs;model development;Modeling;Molecular;Muller's cell;nanovesicle;Natural regeneration;neuroinflammation;Neurons;neuroprotection;novel;overexpression;Paracentesis;Pathway interactions;Patients;Permeability;Physiologic Intraocular Pressure;Play;precision medicine;preconditioning;prevent;Property;protective effect;Public Health;Publishing;randomized, clinical trials;repaired;Reporting;response;restoration;Retina;retinal damage;Retinal Diseases;Retinal Ganglion Cells;retinal ischemia;retinal neuron;Rodent Model;Role;Specificity;stem cells;Stroke;stroke model;success;System;Testing;Therapeutic;thrombolysis;tool;transcriptome sequencing;Translating;translational medicine;Vascular Diseases;Vascular Endothelial Cell;vascular injury;Vision

PROJECT_TITLE: Mesenchymal stem cell extracellular vesicles for ischemic retinal damage

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: NARRATIVE Pediatric Restricted Cardiomyopathy (RCM) is a severe, childhood onset disease that causes heart failure and death and has no definitive treatment other than heart transplantation. This proposal uses human in vitro stem cell-based models of RCM to evaluate the therapeutic potential of a newly approved drugs that have shown promise in other forms of heart disease. The proposed mechanistic studies and drug testing are critical steps needed prior to clinical implementation.

PI_NAMEs: MERCOLA, MARK  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: 3-Dimensional;Actins;Address;Affect;autosome;beta-Myosin;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cessation of life;Chemicals;Childhood;Chromatin Structure;Clinical;clinical implementation;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;design;Dimensions;Disease;disease model;disease phenotype;drug candidate;drug testing;Effectiveness;efficacy evaluation;Etiology;Evaluation;Exhibits;Fibrosis;Functional disorder;Gene Mutation;Generations;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Glucose;Heart Diseases;Heart failure;Heart Transplantation;Human;Hyperactivity;improved;In Vitro;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;inhibitor;Investigation;Modeling;Molecular;molecular phenotype;Mutation;Myosin ATPase;Myosin Heavy Chains;Onset of illness;Outcome;Pathogenesis;Pathogenicity;Pathologic;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;Proteins;Reporting;Rest;Restrictive Cardiomyopathy;Sarcomeres;Sodium;stem cell model;Study models;symporter;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutically effective;Thick;transcriptome;transcriptome sequencing;Transplantation;Treatment Efficacy;Troponin I;Troponin T;Ventricular;Ventricular Remodeling

PROJECT_TITLE: hiPSC Modeling of Restrictive Cardiomyopathy for Drug Testing

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Receptors for glutamate, the main excitatory transmitter in the brain, come in three types of which kainate receptors, functionally, are the least well understood. Kainate receptors have been implicated in the signaling of pain, epilepsy, and mood disorders, and thus understanding more about this class of receptor is relevant to human health. Kainate receptors play a surprisingly large role in retinal signaling where both their function and interactions with drugs can be studied.

PI_NAMEs: CONTRACTOR, ANIS ;DEVRIES, STEVEN H;SWANSON, GEOFFREY T;ZHU, YONGLING  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Acids;Acute;Address;Adult;Affinity;AMPA Receptors;Anatomy;Area;authority;Autoimmune Diseases;Binding;Brain;candidate identification;Cell Culture Techniques;cell type;Cells;Chief Cell;Communication;Cone;Contractor;CRISPR/Cas technology;Data;Databases;desensitization;Development;Epilepsy;Excision;Excitatory Synapse;experimental study;Frequencies;Genetic Diseases;genetic manipulation;Germ Lines;Glutamate Receptor;Glutamates;Health;Human;in vivo;Individual;Interneurons;kainate;Kainic Acid Receptors;Kinetics;Knock-out;Light;Measures;Mediating;Metabotropic Glutamate Receptors;Modality;Modification;Molecular;Molecular Genetics;Mood Disorders;mouse model;Mus;outer plexiform layer;pain signal;Pathway interactions;Perfusion;Pharmaceutical Preparations;Photoreceptors;Physiologic pulse;Physiological;Play;preservation;Primates;Process;Property;Proteins;Proteomics;receptor;Receptor Cell;receptor expression;receptor function;Recovery;Regulation;response;Retina;Retinal Cone;RNA Splicing;Role;Signal Transduction;Spermophilus;Structure;superresolution microscopy;Synapses;System;tool;transcriptomics;transmission process;Viral;Vision;visual information;Work

PROJECT_TITLE: Regulation of kainate receptor expression in cone bipolar cells

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences;Prevention;Sleep Research

PHR: PUBLIC HEALTH RELEVANCE Cognitive dysfunction after surgery and anesthesia is a frequent, devastating complication in patients over the age of 65. Sleep disturbance around the time of surgery has been identified as an important risk factor but the mechanisms by which disrupted sleep contributes to impaired cognition after surgery is poorly understood. This research will investigate how neurons in the hypothalamus that regulate sleep-wake states mediate sleep- dependent cognitive performance after surgery and anesthesia, and test a novel pharmacological approach that can potentially benefit surgical patients.

PI_NAMEs: MASHOUR, GEORGE ALEXANDER;VANINI, GIANCARLO  (contact)

PROGRAM_OFFICER_NAME: ROBERTS, LUCI

PROJECT_TERMS: Acute;Age;Anesthesia procedures;Architecture;Arousal;Attention;Brain;Caffeine;Calcium;Caring;Clinical;Cognition;cognitive ability;cognitive function;cognitive performance;Complication;Critical Care;Data;Delirium;design;Development;Distress;effective intervention;effective therapy;Electroencephalography;expectation;experimental study;General Anesthesia;Generations;Genetic;Glutamates;Goals;Head;Homeostasis;Human;human old age (65+);Hypothalamic structure;Image;Imaging technology;Impaired cognition;Impairment;improved;Intervention;Knowledge;Laboratories;Lateral;Length of Stay;Measures;Medial;medial preoptic nucleus;Mediating;Memory;microscopic imaging;mortality;mouse model;Mus;neurocognitive disorder;neuromechanism;Neurons;non rapid eye movement;novel;object recognition;Operative Surgical Procedures;Optics;Patients;Pattern;Performance;Perioperative;pharmacologic;Postoperative Period;pragmatic intervention;Preoptic Areas;preoptic nucleus;prevent;public health relevance;Reaction;REM Sleep;Research;Risk Factors;Rodent Model;Role;Site;Sleep;Sleep Deprivation;Sleep Disorders;Sleep disturbances;sleep onset;sleep regulation;Surgical Models;System;Testing;Time;Translating;translational potential;Wakefulness;Work

PROJECT_TITLE: Role of preoptic hypothalamus in sleep-dependent cognition after surgery and general anesthesia

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PULLMAN

ORG_DEPT: BIOLOGY

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: Project narrative This project experimentally investigates how the amount, identity, and structure of genetic variation shape the fundamental biological process of adaptation. Using molecular genetics tools in natural experiments with Drosophila melanogaster to manipulate and observe adaptation in real time will provide crucial new insight into what dictates the pace and predictability of adaptation. The knowledge gained about the process of adaptation from these experiments is directly relevant to several biological dynamics influencing human health (e.g., vector-borne disease, human genetic variation, the dynamics of cancer), and to understanding how global change alters populations and ecosystems that are central to human well-being.

PI_NAMEs: RUDMAN, SETH  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TERMS: Animals;Architecture;Bioinformatics;Biological;Biological Process;Biology;Complex;Data;Demography;Diploidy;Drosophila melanogaster;Ecosystem;Environment;Evolution;experimental study;Genes;Genetic Structures;Genetic Variation;genomic variation;Genomics;Genotype;Global Change;Goals;Health;Human;Human Genetics;insight;Knowledge;Malignant Neoplasms;Molecular Genetics;Natural experiment;outcome prediction;Pattern;Personal Satisfaction;Phenotype;Population;Population Genetics;Process;programs;Research;Retrospective Studies;Shapes;Testing;Time;tool;trait;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Empirical tests of the contributions of genomic variation to the trajectories of adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: The proposed project seeks to clarify the mechanism of action of tau antibodies in Alzheimer's disease and related tauopathies, and to develop novel therapies to target pathological tau protein in these diseases. The studies should provide valuable insight into tau pathogenesis, are likely to identify clinical candidates to target pathological tau protein for therapy, and will guide the development of other candidates by various companies. Hence, this research is very relevant to public health.

PI_NAMEs: SIGURDSSON, EINAR M (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Active Immunization;Acute;Address;Advocate;Affect;Affinity;Alzheimer's Disease;Amino Acids;Antibodies;Antigen-Antibody Complex;Antigens;arm;Attention;Binding;Binding Sites;Biochemical;Biological Assay;Calcium;Charge;Chimera organism;clinical candidate;Clinical Trials;Complex;confocal imaging;Crystallization;Data;Development;Disease;Engineering;Epitope Mapping;Epitopes;experimental study;extracellular;fly;follow-up;Foundations;Human;IgG1;IgG3;IgG4;Image;Immunoglobulin G;Immunotherapy;In Vitro;in vivo;in vivo Model;insight;Laboratories;Malignant Neoplasms;Measurement;Microglia;Modeling;Modification;Mus;nanobodies;Neurons;novel;novel therapeutics;Outcome;Outcome Study;Passive Immunization;Pathogenesis;Pathologic;Penetration;Phagocytosis;Phosphoserine;pre-clinical;prevent;Property;protein aggregation;Protein Conformation;prototype;Public Health;Publications;Publishing;Reporting;Reproducibility;Research;Safety;Structure;tau aggregation;tau conformation;tau function;tau Proteins;Tauopathies;Technology;Therapeutic;therapy development;Tissues;Toxic effect;uptake;Vaccines

PROJECT_TITLE: Epitope-Specific Targeting of Tau Aggregates

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND-M]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: DURHAM

ORG_NAME: SCITOVATION, LLC

ORG_STATE: NC

PHR: PROJECT NARRATIVE Mutations are heritable changes in the cellular genome and are key events in the induction of cancer, birth defects, and neurological diseases. Screening chemicals for their potential to cause mutation in a human- relevant assay offers an effective strategy for improving public health. The lack of a mutagenicity bioassay in human cells is a major data gap in the genetic toxicology test battery used by regulatory agencies for hazard identification and quantitative risk assessments. Current human cell mutagenicity bioassays are labor intensive and rely on 50-year-old clonal selection techniques. Error Corrected Next Generation Sequencing (EC-NGS) is a direct method for analytical assessment of mutagenicity with precise quantification of these very rare events in DNA. The focus of this Direct-to-Phase II SBIR application is to develop a New Approach Methodologies (NAMs) combining human cells and EC-NGS as an in vitro alternative to current regulatory mammalian cell mutagenicity assessment using rodent cell lines, and as an in vitro alternative to in vivo mutation assays. The development of human cell mutagenicity assays will be part of ScitoVation’s nonanimal Next-Generation genotoxicity assessment using NAMs and dosimetry to improve human safety assessments. We will accomplish this by defining experimental parameters to quantify the induction of mutations by EC-NGS in two distinct human cell lines: TK6 lymphoblastoid cells and metabolically competent human HepaRG™ cells. Although EC-NGS is highly innovative and a “game changer,” without integration into well-defined human cell-based systems and careful validation studies, its application in regulatory Genetic Toxicology is limited. Human TK6 cells are a well- established and validated cell line with worldwide acceptance for mutagenicity assessments. However, TK6 cells lack drug-metabolizing enzymes. Metabolically competent human liver HepaRG™ cells express Phase I and Phase II drug metabolizing enzymes and have been used to assess genotoxicity. However, the requirement for two rounds of cell cycling to fix DNA damage into mutations, the prolonged cell cycling time of 10-14 days, and lack of clonal selection techniques to quantify mutations in HepaRG™ cells have precluded the development of mutagenicity testing in HepaRG™ cells. In this SBIR, we aim to replace 50 yr. old clonal selection techniques to assess mutation in mammalian cells by using EC-NGS to quantify mutations in human TK6 and HepaRG™ cells. Specific Aim 1 – Define experimental parameters to assess mutagenicity by EC-NGS in human TK6 cells and validate TK6 EC-NGS as a replacement for current mammalian cell in vitro mutagenicity testing bioassays. Specific Aim 2 – Define experimental parameters to assess mutagenicity by EC-NGS in HepaRG cells and validate HepaRG™ EC-NGS as a replacement for in vivo mutagenicity assessment in rodents. Completion of this Phase II SBIR will produce two human cell-based mutation assays that can be used as a follow-up to bacterial mutation assays and as a NAM to reduce reliance on current in vivo gene mutation assays in rodents. These assays will be a cornerstone of ScitoVation’s NAMs-based vision on Next Generation genotoxicity assessment using human-relevant cell-based models and dosimetry for human safety and risk assessments.

PI_NAMEs: RECIO, LESLIE  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Amendment;analytical method;Animal Testing;Animals;Biological Assay;carcinogenesis;Cell Cycle;Cell Line;Cells;Chemicals;Chromosome abnormality;Client;Congenital Abnormality;Cosmetics;cost;Data;daughter cell;Detection;Development;DNA;DNA Damage;dosimetry;drug candidate;environmental chemical;Enzymes;European Union;Event;experimental study;follow-up;Food Additives;Gene Mutation;Genetic;Genome;genotoxicity;Goals;Hazard Identification;Hepatocyte;Heritability;Human;Human Cell Line;Human Genome;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Induced Mutation;innovation;Liver;Mammalian Cell;Measures;Metabolic;Methodology;Methods;micronucleus;Modeling;Mutagenicity Tests;Mutagens;Mutation;mutation assay;Mutation Fixation;Nature;Nervous System Disorder;new technology;next generation;next generation sequencing;novel strategies;novel therapeutics;Pesticides;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Poison;Public Health;rare variant;response;Risk Assessment;Rodent;safety assessment;Sales;Scheme;screening;Small Business Innovation Research Grant;success;System;Techniques;Test Result;Testing;Time;Toxic effect;Toxicity Tests;Toxicogenetics;Toxicology;Transgenic Organisms;transmission process;Validation;validation studies;Vision

PROJECT_TITLE: Mutational profiling in human cells as an in vitro alternative to in vivo mutagenicity assessments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(10)]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIDDEFORD

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: Chronic pain continues to be a major health, social and economic problem throughout the world, affecting an estimated 1 in 3 individuals. Current therapies for chronic pain offer only modest efficacy and/or have serious side-effects. As a result, there is a need to focus on treating pain, on preventing the development of chronic pain, and on research and development of novel treatments (including restoration of lost function and improvement of quality of life).

PI_NAMEs: MENG, IAN D (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acute Pain;addiction liability;Advisory Committees;Affect;alternative treatment;Applications Grants;Award;base;Behavior;Biological;Biomedical Research;Businesses;career development;Centers of Research Excellence;chronic pain;chronic pain management;Classification;Clinical;Collaborations;Communities;Consultations;Continuing Education;Contract Services;Contracts;Core Facility;COVID-19 impact;Dedications;Development;Doctor of Philosophy;Economics;Educational workshop;Engineering;Environment;Epidemic;Equipment;Extramural Activities;Faculty;Fee-for-Service Plans;Fees;Fellowship;Financial Support;Funding;Goals;Grant;Health;higher education;Histology;Human Resources;Image;Immune;improved;Income;Individual;Industry;industry partner;Institution;instrumentation;Intervention;Investments;Joints;Journals;Laboratories;Learning;Maine;Maintenance;Marketing;Medical Research;Mentorship;Neurons;Neurosciences;New England;New Hampshire;novel;Opioid;opioid epidemic;Pain;pain chronification;pain relief;Pain Research;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phase I Clinical Trials;Pilot Projects;Population;prescription opioid;prevent;Program Development;Program Research Project Grants;programs;Publications;Quality of life;recruit;Research;Research Activity;research and development;research facility;Research Institute;Research Personnel;Research Project Grants;Research Support;restoration;reuptake;Science;Scientific Advances and Accomplishments;Secure;Sensory;Series;Services;Severities;side effect;Signal Pathway;Signal Transduction;skills;Small Business Innovation Research Grant;Small Business Technology Transfer Research;social;Strategic Planning;Students;success;Sustainable Development;sustainable resource;Time;Training;Travel;Universities;voucher;Wages;Work

PROJECT_TITLE: Interdisciplinary Center of Excellence for the Study of Pain and Sensory Function


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Pain Research

PROJECT_TERMS: Advisory Committees;Area;Award;base;Benchmarking;Budgets;Businesses;career;career development;Centers of Research Excellence;Collaborations;Communication;Continuing Education;Contracts;Core Facility;cost;Department chair;Development Plans;Educational workshop;Ensure;Environment;Evaluation;Evaluation Research;Excision;Expenditure;Faculty;Feedback;Fees;Funding;Goals;Grant;Grant Review;Guidelines;Individual;Industry;Institution;Intellectual Property;International;Leadership;Maine;Marketing;Mentors;Mentorship;Modeling;Monitor;Neurosciences;New England;Pain;Performance;Persons;Phase;Pilot Projects;Process;Productivity;Professional Organizations;Program Development;programs;Published Comment;Recommendation;recruit;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Sensory;Series;Services;Solid;Strategic Planning;Structure;success;supportive environment;symposium;Teacher Professional Development;tenure track;Time;Training;Travel;United States National Institutes of Health;Universities;Validation;Visit;Vocational Guidance;voucher;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Neurosciences;Pain Research

PI_NAMEs: KING, TAMARA E (contact)

PROJECT_TERMS: Academia;addiction;Affective;Animal Experimentation;Anxiety;Area;base;Behavior;behavior test;Behavioral;Behavioral Assay;behavioral study;Biological;Biomedical Research;Breeding;Businesses;Caliber;Centers of Research Excellence;chronic pain;Client;Cognitive;cohort;college;Communities;comorbidity;Consultations;Contracts;Core Facility;cost;Cost Sharing;Data Analyses;Dedications;Department chair;Development;drug development;drug discovery;Educational workshop;Endowment;Ensure;Equipment;equipment acquisition;Experimental Designs;experimental study;Extramural Activities;Faculty;faculty support;Fee-for-Service Plans;Feedback;Fees;field study;Fostering;Foundations;Funding;Gene Modified;Genotype;Goals;Grant;Growth;Human Resources;Impaired cognition;in vivo evaluation;Income;Industry;industry partner;innovation;Institution;instrumentation;Investments;Island;Laboratories;Letters;Maine;Maintenance;Marketing;Measures;Medical Research;Mental Depression;model development;Modeling;mouse model;Mus;neural circuit;Neurons;New England;nociceptive response;Operative Surgical Procedures;optogenetics;Osteopathic Medicine;Pain;Pain Measurement;pain model;pharmacologic;Phase;pre-clinical;Procedures;programs;Protocols documentation;Publications;Rattus;Reproducibility;Research;Research Institute;Research Personnel;Research Support;Resources;Rodent;Sensory;Services;Standardization;Strategic Planning;Stream;Structure;Students;sustainable resource;Technical Expertise;Techniques;Technology;Testing;Time;tool;Training;training opportunity;Transgenic Mice;United States National Institutes of Health;Universities;Validation;voucher;Work

PROJECT_TITLE: Behavior Core


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: Bethesda

ORG_NAME: ROSE LI AND ASSOCIATES, INC.

ORG_STATE: MD

PHR: Project Narrative “NIA Collaboratories for Artificial Intelligence and Healthy Aging” or AHA Collab will serve as the coordinating center for AI and Technology Collaboratories for Aging Research (AITC). In addition to providing strategic leadership, efficient coordination, creative dissemination, and effective project management, review, evaluation, and reporting services, AHA Collab will feature AHA Combinator—an incubator that not only matches technologies with capital but also more importantly connects funded pilot projects with strategic and tactical guidance, resources, and mentorship. AHA Collab activities will be focused on potentiating the success of the AITCs and successfully translating research to application for the benefit of older Americans.

PI_NAMEs: LEE, ALBERT ;LI, ROSE MARIA (contact)

PROGRAM_OFFICER_NAME: BHATTACHARYYA, PARTHA

PROJECT_TERMS: Academia;Achievement;Adoption;Aging;American;Area;Artificial Intelligence;Artificial Intelligence platform;Businesses;Capital;Caregivers;Caring;catalyst;cloud based;Collaborations;collaboratory;commercialization;Communication;Communities;Creativeness;Data;data dashboard;data visualization;Dementia;design;Development;diversity and inclusion;Educational workshop;Ensure;Ethics;Evaluation;Event;experience;Funding;Government;Health;healthy aging;improved;Incubated;Incubators;Industry;Infrastructure;innovation;Joints;Leadership;Learning;machine learning algorithm;Managed Competition;Marketing;meetings;Mentorship;National Institute on Aging;Older Population;online community;Outcome;outreach;Persons;Pilot Projects;Policy Maker;Positioning Attribute;Process;Productivity;Program Reviews;programs;Psyche structure;public-private partnership;Recommendation;Reporting;Research;research and development;Research Personnel;Resources;Science;Services;success;Surveys;symposium;Talents;Technology;tool;Translating;Translational Research;United States;user-friendly;virtual;web site;Work

PROJECT_TITLE: AI + Aging (a2) Coordinating Center for the NIA Artificial Intelligence and Technology Collaboratories for Aging Research (AITCs)


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Neurosciences

PHR: Psychiatric disorders are prevalent and contribute to long-term social and occupational dysfunction, including poverty, homelessness, suicide and substance abuse, as well as chronic suffering and family burden. It is known that psychiatric disorders are caused by changes in the brain due to genetic and environmental factors, but the specific factors and brain changes causing psychiatric disorders are not well understood. Training psychiatrists-scientists who are able to lead cutting edge translational research projects will allow us to understand the causal factors and brain abnormalities involved in psychiatric disorders, and to develop better treatments and diagnostic and prevention strategies.

PI_NAMEs: NEW, ANTONIA S;PEREZ RODRIGUEZ, MARIA DE LAS MERCEDES  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: ABCB1 gene;Acceleration;Adult;Award;Back;Basic Science;Behavioral Sciences;Brain;brain abnormalities;career;career development;Chronic;Clinic;Clinical;Clinical Research;clinical training;cohort;Coupled;critical period;Data;design;Development Plans;diagnostic strategy;disability;Disease;Doctor of Philosophy;Education Projects;education research;Ensure;Environmental Risk Factor;experience;Explosion;Faculty;family burden;Foundations;Functional disorder;Funding;Genetic;Genomics;Goals;Grant;hands on research;High Prevalence;Homelessness;improved;Individual;Institution;Intervention;K-Series Research Career Programs;Lead;Leadership;Length;medical specialties;meetings;Mental disorders;Mentors;Mentorship;Mission;National Institute of Mental Health;Neurobiology;neuropsychiatric disorder;Neurosciences;next generation;Occupational;Outcome;Patient-Focused Outcomes;physician-scientist training program;Physicians;Pilot Projects;Positioning Attribute;Poverty;Prevention;Prevention strategy;Process;Productivity;Program Description;programs;Psychiatrist;Psychiatry;Recovery;recruit;Research;Research Personnel;Research Project Grants;Research Training;Residencies;Scientist;skill acquisition;skills;social;Structure;Substance abuse problem;success;Suicide;symposium;Time;Training;translational physician;Translational Research;translational scientist;Travel;treatment strategy;United States National Institutes of Health;Writing

PROJECT_TITLE: Training the Next Generation of Psychiatrists-Scientists for Translational Research


PI_NAMEs: MOLLIVER, DEREK C (contact)

PROJECT_TERMS: Academia;Advisory Committees;Antibodies;Applications Grants;Award;base;Biological;Biomedical Research;bone;Brain;Businesses;Caliber;Caring;Centers of Research Excellence;Collaborations;Communication;Communities;Computer software;Contract Services;Contracts;cryostat;Data;Dedications;Densitometry;Development;Education;Ensure;Equipment;Evaluation;experience;experimental study;Extramural Activities;Faculty;Fee-for-Service Plans;Feedback;Fees;Fluorescence;Freezing;Funding;Goals;Grant;Histologic;Histology;Human Resources;Image;Image Analysis;imaging capabilities;Immunohistochemistry;Income;Industry;industry partner;Institution;instrumentation;Investments;Laboratories;Laboratory Personnel;Maine;Maintenance;marine;Marketing;Medical center;Methods;Microscope;Microtome - medical device;New England;outreach;Pain;Paraffin Embedding;Performance;Phase;Plastic Embedding;Procedures;programs;Provider;Publications;quantitative imaging;Reproducibility;Research;research facility;Research Institute;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;Role;Sampling;Scanning;Secure;Sensory;Service delivery model;Services;Slide;Stains;Strategic Planning;Stream;Students;success;synergism;System;Technical Expertise;Time;Tissue Embedding;Training;two photon microscopy;two-photon;United States National Institutes of Health;Universities;Validation;voucher;Wages;Work

PROJECT_TITLE: Histology and Imaging Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: LARAMIE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: The Wyoming IDeA Networks for Biomedical Research Excellence (INBRE) Program is funded by the National Institutes for Health National Institute for General Medical Sciences (NIGMS). The ultimate goal of Wyoming INBRE is to work with the University of Wyoming and Wyoming’s community colleges to promote the development, coordination, and sharing of research resources and expertise that will expand biomedical-related research and education opportunities and increase the number of competitive investigators in Wyoming. INBRE programs implemented are intended to enhance the caliber of scientific faculty at research institutions and undergraduate schools, thereby attracting more promising students to these organizations.

PI_NAMEs: SEVILLE, ROBERT SCOTT (contact)

PROGRAM_OFFICER_NAME: MATUKUMALLI, LAKSHMI KUMAR

PROJECT_TERMS: Acceleration;Achievement;Ally;Area;Award;base;Bioinformatics;Biomedical Research;biomedical scientist;Biomedical Technology;Biotechnology;Caliber;cardiometabolism;career;Cellular biology;Chronic Disease;Clinical Research;Collaborations;college;commercialization;community collaboration;community college;community partners;Development;Disease;Doctor of Philosophy;Education;Employee;Employment;Engineering;Equipment;Faculty;faculty mentor;faculty research;faculty support;Fellowship Program;Funding;Funding Opportunities;Goals;Government;graduate student;Grant;Growth;Health;Health Professional;Idaho;Immunoglobulin Joining Region;improved;Industry;informal learning;Infrastructure;infrastructure development;Institution;instrument;Interdisciplinary Study;Internships;Investments;Knowledge;Laboratories;Leadership;Methods;Molecular;Molecular Biology;Montana;National Institute of General Medical Sciences;Network Infrastructure;New Mexico;next generation;Phase;Postdoctoral Fellow;Program Development;Program Research Project Grants;programs;Research;research faculty;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Role;Schools;Science;Scientist;State Government;student mentoring;student training;Students;success;summer program;summer student;synergism;Technology;Technology Transfer;Training;training opportunity;Translational Research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Work;Wyoming

PROJECT_TITLE: Wyoming IDeA Networks for Biomedical Research Excellence Phase 4


PROJECT_TERMS: Advisory Committees;Applications Grants;Appointment;Award;base;Behavior;Budgets;career;Centers of Research Excellence;chemotherapy induced neuropathy;Collaborations;Core Facility;Data;Decision Making;Development Plans;Direct Costs;Drosophila genus;Eligibility Determination;Ensure;Environment;experience;Extramural Activities;Faculty;Foundations;Funding;Funding Agency;Future;Gene Targeting;Goals;graduate student;Grant;Guidelines;gut microbiome;Histology;Home;Image;Individual;industry partner;inflammatory pain;Injury;innovation;Institution;Letters;Maine;Medical center;meetings;Mentors;Modeling;National Institute of General Medical Sciences;New England;New Hampshire;novel;Pain;Pain Research;Persons;Phase;Pilot Projects;Policies;Postdoctoral Fellow;Prevention;Procedures;Process;Program Development;programs;Progress Reports;Publications;Recommendation;recruit;Research;research faculty;Research Institute;Research Personnel;Research Proposals;Review Committee;Scientific Advances and Accomplishments;senior faculty;Sensory;Services;Strategic Planning;Study Section;symposium;Teacher Professional Development;Therapeutic Intervention;Time;timeline;Training;Training Support;United States National Institutes of Health;Universities;Update;Vocational Guidance;voucher;Wages;Work;Writing

PROJECT_TITLE: Pilot Project Program


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding

PROJECT_TERMS: Acceleration;Accounting;Advisory Committees;Animals;Area;base;Basic Science;Bioinformatics;Biomedical Research;Businesses;career;career development;Charge;Clinical Research;Collaborations;commercialization;Communication;community college;Core Facility;Cost Sharing;Country;design;Development;Economic Development;Education;Educational Activities;Educational workshop;Electronics;Ensure;equipment acquisition;Evaluation;Faculty;Fertilization;forging;Fostering;Funding;Funding Agency;Goals;graduate student;Guidelines;Health;Human;Idaho;improved;Infrastructure;Institution;Interdisciplinary Study;Knowledge;Laws;Lead;Leadership;lectures;meetings;member;Mentors;Mentorship;Montana;National Institute of General Medical Sciences;Network Infrastructure;New Mexico;Participant;Phase;Postdoctoral Fellow;Principal Investigator;Productivity;Program Research Project Grants;programs;recruit;Research;Research Activity;research and development;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;Rural;Science;Scientist;Series;Site;Small Business Technology Transfer Research;Structure;Students;success;symposium;Technology;Technology Transfer;Training;Training and Education;Training Programs;Translational Research;undergraduate research experience;undergraduate student;United States National Institutes of Health;Universities;Visit;Wages;Work;Wyoming

PROJECT_TITLE: Wyoming INBRE Administrative Core


PI_NAMEs: WARD, NAOMI  (contact)

PROJECT_TERMS: Address;Bioinformatics;bioinformatics infrastructure;bioinformatics resource;Biological;Biomedical Research;career;college;community college;Computational Biology;computerized tools;Data;Data Analyses;Data Science;Data Set;Dedications;Demographic Factors;Development;Education;Education and Outreach;Educational Curriculum;Educational process of instructing;Environment;experience;Exposure to;Extramural Activities;Faculty;Fostering;Funding;Generations;Geographic Factor;Goals;Grant;higher education;Human Resources;improved;innovation;Internships;Methodology;Mission;novel;organizational structure;Outcome;Peer Review;Phase;Positioning Attribute;Productivity;programs;Publications;Qualifying;Research;Research Personnel;Research Project Grants;Research Support;Resources;Reverse engineering;Review Literature;Role;Scientist;skills;State Government;Structure;Students;System;Training;Travel;undergraduate student;Universities;Vision;ward;Work;Workforce Development;Wyoming

PROJECT_TITLE: Wyoming INBRE Bioinformatics Core


PI_NAMEs: FAY, DAVID S (contact)

PROJECT_TERMS: Advisory Committees;Area;Assistantship;Award;Bioinformatics;Biology;Biomedical Research;Budgets;career development;Categories;Cells;Cellular biology;Chalk;Chronic Disease;Collaborations;community college;Data Science;design;Development;Eligibility Determination;Ensure;Equipment;Evaluation;Faculty;faculty support;Feedback;Foundations;Funding;Funding Opportunities;Goals;graduate student;Grant;Health;Individual;Infrastructure;Institution;inter-institutional;Investments;Laboratories;Manuscripts;Mentors;Methods;Molecular Biology;Monitor;National Institute of General Medical Sciences;Outcome;Output;outreach;Paper;Phase;pilot test;Play;Productivity;Program Research Project Grants;programs;Publications;Publishing;Recommendation;Research;Research Personnel;Research Project Grants;Research Support;Resources;Review Committee;Role;Science;student participation;student training;Students;synergism;System;technology development;Training;training opportunity;transfer student;undergraduate student;Universities;Work;Wyoming

PROJECT_TITLE: Wyoming INBRE Developmental Research Project Program


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Climate-Related Exposures and Conditions;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infertility;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Mental Illness;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Miscarriage is the most common pregnancy complication in the US occurring in 15-20% of clinically recognized pregnancies; current analytic approaches, however, depend on early pregnancy losses being identified in the medical system. Ambient air pollution is an increasingly recognized risk factor for pregnancy complications, but quantification of the impact on pregnancy loss is limited by these events being identified through medical records. We propose to use a novel approach, using the outcome metric of live birth-identified conceptions and a variation of the time-series design, to (1) investigate the association between air pollution and pregnancy loss, (2) identify critical windows of vulnerability, and (3) identify important maternal- and neighborhood-level modifiers of this association to inform targeted policies and interventions.

PI_NAMEs: DEYSSENROTH, MAYA ARIANE (contact);KIOUMOURTZOGLOU, MARIANTHI-ANNA ;WEISSKOPF, MARC G

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: Address;Adverse effects;Air Pollutants;Air Pollution;ambient air pollution;anxiety symptoms;Autoimmune Diseases;Biological;Birth;Birth Rate;Birth Records;Body mass index;Boston;built environment;Cardiovascular Diseases;Characteristics;Clinical;coarse particles;Conceptions;Country;Coupled;Data;Denmark;density;Dependence;depressive symptoms;deprivation;design;Distress;early pregnancy loss;Evaluation;Event;fine particles;Future;Gestational Diabetes;Green space;Grief reaction;Health;High Prevalence;Individual;innovation;insight;Intervention;Israel;lifestyle factors;Link;Live Birth;Location;Major Depressive Disorder;Medical;medical attention;Medical Records;Methodology;Methods;Modeling;modifiable risk;Modification;Mothers;Neighborhoods;novel;novel strategies;Outcome;Parents;particle exposure;Particulate Matter;Pathway interactions;Policies;Population;Population Database;Population Research;Post-Traumatic Stress Disorders;Pre-Eclampsia;predictive modeling;Predisposition;Pregnancy;Pregnancy Complications;Pregnancy loss;prepregnancy;Psychological Impact;Public Health;Publishing;Regulation;Research;Resources;Risk;Risk Factors;rural setting;Sample Size;Series;smoking during pregnancy;Socioeconomic Status;spatiotemporal;Spontaneous abortion;Statistical Methods;Subgroup;suburb;Symptoms;System;Time;traffic-related air pollution;United States;Variant;Woman;Work;zygote

PROJECT_TITLE: Air Pollution and Pregnancy Loss

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments. The proposed project will provide first insight into the intracranial neurophysiological signatures of fear and anxiety in patients with varying levels of dysfunction and/or dysregulation of arousal and negative valence systems. Findings will address questions about the relationship between intracranial neurophysiological activity, neurostimulation, and physiological responses during fear-related states and help lay the foundation for future treatments for illnesses marked by debilitating anxiety.

PI_NAMEs: LANGEVIN, JEAN-PHILIPPE ;SUTHANA, NANTHIA A (contact)

PROGRAM_OFFICER_NAME: TILGHMAN, JESSICA IRENE

PROJECT_TERMS: Acute;Address;Adult;Affect;Amygdaloid structure;Animal Model;Anxiety;Anxiety Disorders;anxiety symptoms;Arousal;Arousal and Regulatory Systems;Aversive Stimulus;Behavior;Behavioral;Biometry;Blinking;brain research;Categories;Clinical;Collaborations;conditioned fear;Coupling;design;Development;Diagnostic;Distress;Electric Stimulation;Electrodes;Electroencephalography;emotion regulation;Emotional;emotional distress;emotional reaction;Emotions;Environment;Epilepsy;Event;Exposure to;Extinction;Foundations;Fright;Functional disorder;Future;Galvanic Skin Response;Generalized Anxiety Disorder;Goals;Healthcare Systems;heart rate variability;Hippocampus;Human;Implant;Implanted Electrodes;improved;Individual;innovation;insight;interdisciplinary collaboration;Laboratories;Laboratory Animal Models;Link;Los Angeles;Measures;Medial;Memory;Negative Valence;neural;neural implant;neural network;Neurons;neurophysiology;next generation;novel;novel therapeutic intervention;Participant;Pathological anxiety;Pathology;Patients;Physiological;Physiology;Post-Traumatic Stress Disorders;Prefrontal Cortex;programs;Pupil;recruit;Regulation;Research Domain Criteria;response;Retrieval;Rodent;Role;Scientist;sensor;Startle Reaction;Stimulus;System;Technology;Therapeutic;therapeutically effective;Translating;United States Department of Veterans Affairs;Veterans;virtual reality;virtual reality environment;wearable device

PROJECT_TITLE: Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Electronic Nicotine Delivery Systems;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE The use of electronic cigarettes has increased despite limited knowledge about their toxicity and health effects. We will recruit diverse e-cigarette users and non-users to evaluate the association of e-cigarette use with subclinical atherosclerosis (and also with endothelial cell health, blood pressure, and inflammation), the association of e-cigarette use with metal exposure, and the potential role of these metals to explain, at least in part, the cardiovascular effects of e-cigarettes. The findings will help fill a critical gap in the knowledge about the long-term effects of e-cigarettes and help guide e-cigarette regulatory action.

PI_NAMEs: NAVAS-ACIEN, ANA  (contact);SHIMBO, DAICHI

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Accounting;Adult;Aerosols;Age Years;Antimony;Arsenic;Atherosclerosis;Biological;Biological Availability;Biological Markers;Blood;blood lead;Blood Pressure;Blood specimen;Blood Vessels;C-reactive protein;Cadmium;Calcium;Cardiac;Cardiotoxicity;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;cardiovascular health;cardiovascular risk factor;Cardiovascular system;cell injury;Characteristics;Chromium;Clinical;clinical practice;Clinical Research;Consumption;coronary artery calcification;Cross-Over Studies;Data;Devices;Disease Marker;Dose;e-cigarette aerosols;Electronic cigarette;electronic cigarette use;electronic cigarette user;electronic liquid;Endothelial Cells;Endothelium;Engineering;epidemiology study;Ethnic Origin;experience;experimental study;former smoker;Future;Health;Heart Rate;Heating;Image;Impairment;Inflammation;Interleukin-6;Knowledge;Laboratories;Lead;Long-Term Effects;Longitudinal Studies;Manganese;Measures;Mediating;Mediation;Medicine;men;Metal exposure;metallicity;Metals;Modeling;multidisciplinary;Myocardial Infarction;never smoker;New York City;Nickel;Nicotine;Nitric Oxide;Outcome Assessment;Oxidative Stress;Participant;particle;Pathway interactions;Pattern;Persons;public health intervention;Questionnaires;racial diversity;recruit;Regulation;Risk;Role;Sampling;Scanning;smartphone based assessment;Smoke;Smoker;Smoking;smoking cessation;Source;Testing;tobacco regulatory science;Tobacco smoke;tobacco smokers;tool;Toxic effect;toxic metal;toxicant;Tungsten;United States National Academy of Sciences;Urine;vaper;vaping;Vasodilation;Visit;Woman;X-Ray Computed Tomography;young adult;Zinc

PROJECT_TITLE: Metal Exposure and Early Cardiovascular Risk in Adult E-Cigarette Users

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Alcohol-related liver disease is a leading cause of morbidity and mortality worldwide with limited effective therapies. This project is to investigate the roles and mechanisms of alcohol-induced peroxisomal dysfunction in bile acid synthesis disorder and the pathogenesis of organ damages. The goal of this project is to explore novel molecular targets for therapeutic interventions.

PI_NAMEs: ZHONG, WEI  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acetaldehyde;Address;Affect;alcohol abuse therapy;Alcohol consumption;alcohol exposure;Alcoholic Hepatitis;Alcoholic Intoxication;Alcoholic Liver Diseases;Alcohols;Bile Acid Biosynthesis Pathway;Bile Acids;Biogenesis;Cell Culture Techniques;cell type;Cellular Metabolic Process;Chronic;Circulation;combat;cytotoxicity;Data;Development;Disease;Disease Progression;dysbiosis;effective therapy;Ethanol Metabolism;Exposure to;FDA approved;Functional disorder;gain of function;Genetic;Goals;gut-liver axis;Hepatic;Hepatocellular Damage;Hepatocyte;hepatoprotective;Homeostasis;In Vitro;Inflammation;insight;Intestines;Knock-out;Knockout Mice;Knowledge;LCN2 gene;Link;Liver;liver inflammation;liver injury;loss of function;Macrophage;Mediating;Metabolic;Metabolic Diseases;microbial;Mitochondria;Molecular;Molecular Target;molecular targeted therapies;Morbidity - disease rate;mortality;mouse model;Mus;novel;Organ;Organelles;overexpression;Pathogenesis;Patients;peroxisome;Play;Predisposition;Prevention;Reporting;Research;Role;Signal Transduction;Stimulus;Testing;Therapeutic Intervention;Toxic effect;toxicant;tumorigenesis;Virus

PROJECT_TITLE: Roles of peroxisomal dysfunction in alcohol-related liver disease

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Clinical Research;Prevention;Tobacco;Tobacco Smoke and Health

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE Laryngeal diseases are common and have major impacts on human health, health care costs, and economic wellbeing. The larynx and vocal folds are lined by a protective epithelium that becomes deranged in cigarette smoke-induced laryngeal diseases. Our research focuses on determining the contribution of laryngeal epithelial basal progenitor cells to normal, injured, and diseased epithelium in order to develop therapies to prevent and treat cigarette smoke-diseased vocal folds.

PI_NAMEs: DIRENZO, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: 3-Dimensional;Address;Affect;Basal Cell;Basal Cell Hyperplasia;Biological;Biology;Breathing;Cell Culture System;Cell Culture Techniques;cell type;Cells;Cellular biology;cigarette smoke;cigarette smoke-induced;Clinical;Coughing;Cultured Cells;Deglutition;Development;Disease;Dose;Economics;Edema;Epithelial Cells;Epithelium;epithelium regeneration;Etiology;Exposure to;exposure to cigarette smoke;Genes;Growth;Health;Health Care Costs;Histologic;Homeostasis;Human;human disease;Impairment;In Vitro;in vitro Model;in vivo;Inhalation;injured;Injury;innovation;insight;Knowledge;Laboratories;Laryngeal Diseases;Laryngeal Epithelium;Larynx;Link;Maintenance;Mediating;Modeling;mouse model;Mus;National Institute on Deafness and Other Communication Disorders;Natural regeneration;non-smoker;novel;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Personal Satisfaction;Physiological;Population;Prevalence;prevent;Production;Proliferating;Property;regenerative;Research;response;Role;Smoke;Smoker;Specimen;stem cells;Surface;Testing;therapeutic target;therapy development;Tissues;transcriptome;transcriptomics;vocal cord;Voice;Voice Disorders;Work

PROJECT_TITLE: Evaluating the role of epithelial basal cells in laryngeal homeostasis and disease development

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative The biomedical sciences are drowning in big data. Progress in ﬁelds such as genomics and medical imaging is being stymied by the lack of appro- priate computational tools. This grant promotes the development of algo- rithms, statistical methods, and software for the analysis of the big datasets encountered in the biomedical sciences.

PI_NAMEs: LANGE, KENNETH L (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: algorithm development;Algorithms;All of Us Research Program;big biomedical data;Big Data;biobank;Biometry;Code;Computer software;computerized tools;Data;Data Correlations;data mining;Data Set;Drowning;Electronic Health Record;Epidemic;genome-wide;genomic data;Genomics;Grant;heterogenous data;high dimensionality;Image;Individual;Medical Imaging;Modeling;Modernization;Parameter Estimation;Programming Languages;Sample Size;Science;Statistical Methods;terabyte;Time;tool;United States Department of Veterans Affairs;United States National Institutes of Health;Veterans;web site

PROJECT_TITLE: Modeling, Inference, and Optimization for Genomic and Biomedical Big Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Comparative Effectiveness Research;Genetics;Human Genome;Prevention

ORG_CITY: SAINT LOUIS

ORG_DEPT: PATHOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The mission of the Alliance Biorepository and Biospecimen Resource (ABBR) is to safeguard and facilitate the use of patient tissue and fluid biospecimens for practice changing cancer research. The ABBR helps to collect, process, and store biospecimens from patients enrolled on NCTN Alliance clinical trials. The ABBR distributes biospecimens for biomarker studies associated with Alliance clinical trials and for secondary studies proposed by the broader cancer research community. Members of the ABBR work with the NCTN and other NCI research networks, contributing scientific leadership to maximize the scientific impact of NCI biospecimen resources. Encompassing multi-PI, multi-institutional pathology and biobanking expertise and hundreds of thousands of high quality, densely annotated biospecimens from several decades of clinical trials, the ABBR represents an unequaled academic resource for translational cancer research.

PI_NAMEs: CICEK, MINE ;FRANKEL, WENDY ;RICHARDS, WILLIAM G;WATSON, MARK A. (contact)

PROGRAM_OFFICER_NAME: LUBENSKY, IRINA

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;anti-cancer research;Automobile Driving;biobank;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;biomarker development;biomarker validation;cancer clinical trial;Cancer Control;Cancer Diagnostics;candidate marker;Clinical;clinical practice;Clinical Research;clinical translation;Clinical Trials;cohort;Collaborations;Collection;Communities;Community Clinical Oncology Program;community setting;Companions;control trial;cost;Data;digital;Eligibility Determination;Equipment and supply inventories;Future;Genomics;Image;Immunologic Monitoring;improved;Informatics;Infrastructure;innovation;Institution;Laboratories;Leadership;liquid biopsy;Liquid substance;Malignant Neoplasms;meetings;member;Methods;minimally invasive;Mission;multidisciplinary;National Clinical Trials Network;new technology;novel;Oncology;operation;participant enrollment;Pathology;Patients;Prevention trial;Procedures;Process;programs;prospective;Proteomics;quality assurance;Research;Resources;Science;Services;single cell sequencing;Site;Slide;Speed;Stratification;targeted treatment;Techniques;The Cancer Genome Atlas;Therapeutic Trials;Time;Tissues;tool;translational cancer research;Translational Research;Translations;treatment trial;trial design;tumor;validation studies;Work

PROJECT_TITLE: The Alliance NCTN Biorepository and Biospecimen Resource


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Nanotechnology;Precision Medicine;Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: The availability of nanoparticles that deliver small interfering RNA (siRNA) have significantly expanded the specificity and range of ‘druggable’ targets making them promising agents for precision medicine in cancer. This is especially important for cancers such as triple negative breast cancer for which there are no targeted treatments. Our goals are to understand the role of the complex tumor microenvironment in siRNA NP delivery and function using clinically translatable molecular and functional imaging techniques as well as ex vivo imaging, to improve the delivery and outcome of siRNA treatment in cancer.

PI_NAMEs: BHUJWALLA, ZAVER M. (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Area;biomaterial compatibility;Blood Vessels;cancer cell;cancer imaging;Characteristics;Chemicals;Choline;Choline Kinase;clinical translation;Collaborations;Collagen;Collagen Fiber;Complex;Data;Dextrans;Down-Regulation;druggable target;Effectiveness;Endothelial Growth Factors;Environment;Evolution;ex vivo imaging;experience;extracellular;Extracellular Matrix;Fiber;Formulation;Functional Imaging;Future;Gene Modified;Gene Silencing;Generations;Genetic Engineering;Goals;Growth Factor Overexpression;Human;Hypoxia;Image;imaging study;Imaging Techniques;Imaging technology;Immunohistochemistry;improved;in vivo;interest;Link;lipidome;lipidomics;Lymphatic;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Malignant Neoplasms;mass spectrometric imaging;MDA MB 231;Mediating;metabolome;metabolomics;Microscopy;Modeling;molecular imaging;multimodality;nanoparticle;nanoparticle delivery;Non-Invasive Detection;optical imaging;Outcome;overexpression;Permeability;Physiological;Porosity;Positron-Emission Tomography;precision medicine;precision oncology;protein expression;Proteome;Proteomics;Reagent;Reporter;Reporting;Resources;response;Response Elements;Role;second harmonic;second harmonic generation imaging;siRNA delivery;Slice;Small Interfering RNA;Specificity;spectroscopic imaging;Testing;theranostics;therapeutic nanoparticles;Tissues;Translations;triple-negative invasive breast carcinoma;tumor;tumor hypoxia;tumor microenvironment;uptake;Vascular Endothelial Growth Factors;Xenograft procedure

PROJECT_TITLE: The Tumor Microenvironment in Nanoparticle Delivery and Function


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: WALTHAM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative: A general rationale for the value of this program is the conviction that human disease must ultimately be understood in terms of the chemistry and physics of biological macromolecules.

PI_NAMEs: OPRIAN, DANIEL D (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Molecular Structure

PROJECT_TITLE: Macromolecular Structure and Mechanism

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


ED_INST_TYPE: GRADUATE SCHOOLS

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCE STATEMENT) The proposed program, MARC at the University of California Santa Barbara (MARC-UCSB), will benefit public health by supporting the education and career development of a diverse group of undergraduate students who will pursue careers in biomedical fields that target improvements in human health. All program participants (undergraduate students, faculty, graduate student and postdoctoral scholar mentors, and university personnel) will be better prepared to either secure careers in the biomedical workforce and be leaders in such fields, or prepare our future workforce leaders.

PI_NAMEs: ROTHMAN, JOEL H. (contact);SHELL, MICHAEL SCOTT

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;American;Awareness;Biomedical Research;California;career;CCL7 gene;Common Good;Communities;community based service;community building;Degree program;disadvantaged student;Doctor of Philosophy;Elements;Eligibility Determination;Environment;experience;Faculty;Goals;graduate student;Hispanic;Hispanic-serving Institution;Infrastructure;innovation;Institution;interest;Internships;Leadership;matriculation;Mentors;Modeling;outreach;peer networks;Phase;Postdoctoral Fellow;programs;Research;Research Personnel;Scholars Program;Scholarship;Science;Series;service learning;skills;social;STEM field;Students;success;symposium;Training;undergraduate student;Underrepresented Students;Universities

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_NAME: NEW YORK UNIVERSITY

PHR: Narrative Many of our front-line, broad-spectrum antibiotics target the synthesis of the bacterial cell envelope and ultimately cause cell death via fracture of this structural exoskeleton. Therefore, determining the molecular basis for the mechanical properties of the cell envelope and, in turn, the mechanisms by which bacteria modify these properties to promote antibiotic resistance will provide brand new strategies to combat this crisis based on undermining the mechanical integrity of bacterial cells. Furthermore, the ability to manipulate the mechanical properties of the cell envelope will provide new tools with which to probe the mechanics of other important physiological processes important for pathogenesis, such rapid proliferation and adaptation to environmental fluctuations.

PI_NAMEs: ROJAS, ENRIQUE  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Address;Antibiotic Resistance;Antibiotics;Bacteria;Bacterial Infections;bacterial resistance;Biochemical;Biological;Biological Assay;Biophysics;Cell Death;cell envelope;Cell Wall;Cells;combat;Dependence;exoskeleton;Explosion;Fracture;Gram-Positive Bacteria;Growth;Hydrostatic Pressure;innovation;Knowledge;Measures;mechanical force;mechanical properties;Mechanics;Membrane;Microbiology;Microfluidics;Microscopy;Modeling;Molecular;Monitor;novel;Pathogenesis;pathogenic bacteria;Physiological Processes;Physiology;Process;Proliferating;Property;protein protein interaction;Research;Resistance;resistance mechanism;Techniques;Teichoic Acids;theories;tool;Weight-Bearing state

PROJECT_TITLE: Exploring mechanical mechanisms of antibiotic resistance

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Social Determinants of Health

ORG_NAME: PACE UNIVERSITY NEW YORK

PHR: Project Narrative Lockdowns to contain the spread of the novel coronavirus (COVID-19) have had profound social and economic consequences. There is a critical need to better understand the economic consequences of lockdowns on mental health, social cohesion, and long-term adaptation, because these consequences have significant policy, clinical intervention, and community-level implications. Using a quasi-experimental multi-level longitudinal design, the proposed project will examine the interplay of broader social- contextual factors and individual social behaviors in response to COVID-19-related economic stress.

PI_NAMEs: MANCINI, ANTHONY DICKINSON (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: adverse outcome;affiliative behavior;Child Care;Chronic;Clinical;Communities;community intervention;Commuting;comparative;contextual factors;Cooperative Behavior;coping;County;COVID-19;COVID-19 impact;Diagnosis;Distress;economic impact;Economics;Elements;emotion regulation;Environment;Exercise;experience;Feeling suicidal;Grouping;Happiness;Human;Human Activities;improved;Individual;individual variation;Industry;insight;inter-individual variation;Intervention;Leisures;Link;Loneliness;longitudinal design;Maps;Measures;member;Mental Health;metropolitan;mutualism;novel coronavirus;Occupations;Participant;Patient Self-Report;Pattern;Peripheral;Personal Satisfaction;Persons;Play;Policies;Population;Process;psychologic;Public Health;Quasi-experiment;Recovery;recruit;resilience;Resistance;Resources;response;Role;Sampling;Schools;social;Social Behavior;social capital;social cohesion;Social Environment;social factors;Social Interaction;Social Network;social relationships;sound;Source;Stress;stressor;Time;Travel;Trust;United States;Variant;virtual;Work;Workplace

PROJECT_TITLE: Social Affiliation, Social Capital, and Longitudinal Adaptation to COVID-19 Economic Stress


ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Lung transplantation is a life extending treatment for patients with end stage lung diseases; however, lung transplant is a relatively new field, and long-term outcomes are disappointing with only ~55% of patients alive at 5 years and many survivors experiencing disabling complications. As a result there are considerable gaps in the understanding of the clinical and biological process that impact upon long term patient and graft outcomes after lung transplant. In this application, we aim to extend follow up data to include detailed long-term graft function and patient centered outcomes on 4177 subjects from of the Lung Transplant Outcomes Group cohort, a multicentered cohort study with rich clinical data and a wealth of biosamples currently focused on primary graft dysfunction and other events occurring in the initial days following lung transplant.

PI_NAMEs: CHRISTIE, JASON D (contact);PALMER, SCOTT M;SINGER, JONATHAN PAUL

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acute Lung Injury;Address;Ancillary Study;Biological;Biological Assay;Biological Process;Blood specimen;Cessation of life;Chronic;Clinical;clinical biomarkers;Clinical Data;clinical risk;cohort;Cohort Studies;Complication;cost;Data;Data Sources;design;Development;disability;Disabling;Distress;early detection biomarkers;Enrollment;epidemiology study;Event;experience;Focus Groups;follow-up;frailty;Functional disorder;functional status;Funding;Future;Generations;Genomics;graft dysfunction;graft failure;graft function;Grant;Hand;health knowledge;health related quality of life;Image;immune function;Impairment;improved;Incidence;Infrastructure;Injury to Kidney;innovation;Intensive Care;Knowledge;Laboratories;Life;Link;Longterm Follow-up;lung allograft;Lung Diseases;lung injury;Lung Transplantation;Measures;microbiome;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;Operative Surgical Procedures;Outcome;Parents;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Personal Satisfaction;Phenotype;phenotypic data;Physical assessment;Physical Function;Physiological;Population;post-transplant;Prognosis;prospective;Prospective, cohort study;Public Health;pulmonary function;Research;Research Personnel;Resources;Risk;Risk Factors;Source;success;Survivors;Symptoms;Syndrome;Time;translational study;Transplant Recipients;Transplantation;Work

PROJECT_TITLE: Long Term Follow up of the Lung Transplant Outcomes Group Cohort


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

PHR: The unprecedented expansion of life expectancy during the past several decades and especially to the continuing retirement of the baby-boomers has led to hitherto unknown expectations related to the retention of physical and cognitive function abilities in the later decades of life. The program described here provides outstanding and highly translational projects aimed at the development of preventive and compensatory measures to enhance the quality of life in an aging population, an issue of premier importance for U.S. public health in the Twenty-First Century.

PI_NAMEs: JAZWINSKI, S MICHAL  (contact)

PROGRAM_OFFICER_NAME: ZHOU, YANG

PROJECT_TERMS: Address;Adopted;Aging;aging population;aging process;aging related disease;Area;aspirate;baby boomer;base;Bioinformatics;Biological Aging;Biological Process;Biomedical Research;career development;Cell Proliferation;Cementation;Centers of Research Excellence;Chronic Disease;Clinical;cognitive function;cohort;Collaborations;Communities;Core Facility;Dedications;Degenerative Disorder;design;Development;Disease;Educational workshop;Elements;Environment;expectation;Extramural Activities;Faculty;Feedback;Foundations;Funding;Genome Stability;Genomics;Goals;Grant;Growth;Health;Homeostasis;Immunity;improved;Inflammaging;Inflammation;Infrastructure;Institution;Interdisciplinary Study;interest;Intervention;Knowledge;Life;Life Expectancy;life span;Maintenance;Measures;medical schools;Mentors;Metabolic;molecular imaging;multidisciplinary;Musculoskeletal;Natural regeneration;Neurocognitive;neuroinflammation;Pathogenesis;Phase;Physical Function;Pilot Projects;Positioning Attribute;Preventive;Program Description;Program Development;programs;psychosocial;Public Health;Quality of life;Regenerative Medicine;Regenerative research;Regulation;Research;Research Infrastructure;Research Personnel;Retirement;Risk Factors;Services;soft tissue;stem cell function;success;sustainable resource;Talents;therapeutic development;Therapeutic Intervention;Time;Training;Training Programs;Twin Multiple Birth;Universities;Update;wound healing

PROJECT_TITLE: Mentoring Research Excellence in Aging and Regenerative Medicine


NIH_SPENDING_CATS: Aging;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine

PROJECT_TERMS: Achievement;Administrator;Advisory Committees;Aging;Area;Bioinformatics;career development;Centers of Research Excellence;cohesion;Collaborations;Committee Members;Communication;Dedications;design;Development;Elements;Ensure;Evaluation;expectation;Faculty;Genomics;Goals;Human Resources;Incentives;Individual;Mentors;molecular imaging;multidisciplinary;Office of Administrative Management;organizational structure;Phase;Pilot Projects;Preparation;Program Development;programs;Regenerative Medicine;Research;Research Personnel;Research Support;Scientific Advances and Accomplishments;Scientist;Series;skills;success;supportive environment;Technology;Vision

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Regenerative Medicine

PI_NAMEs: KIM, SANGKYU  (contact)

PROJECT_TERMS: Aging;Applications Grants;Bioinformatics;bioinformatics pipeline;Biological Assay;Biomedical Research;Biometry;Biostatistics Core;Cancer Center;Capillary Electrophoresis;Cell Line;Cells;Center for Translational Science Activities;Centers of Research Excellence;Charge;Chromium;Client;Clinical;Communities;Computational Biology;Data;Data Analyses;Data Analytics;Dedications;design;Development;Dideoxy Chain Termination DNA Sequencing;DNA;DNA sequencing;Epidemiology;Equipment;equipment acquisition;exome;Experimental Designs;Funding;Gene Expression;Genes;Genomics;Genotype;Goals;Growth;Human Resources;increased appetite;instrumentation;Louisiana;Luciferases;Measurement;Measures;Mentors;Microsatellite Repeats;miRNA expression profiling;Molecular;molecular imaging;multiple omics;Names;next generation sequencing;operation;Peer Review;Phase;Principal Investigator;pro-aging;Productivity;Proteomics;Publications;Quality Control;Regenerative Medicine;Research;Research Personnel;Research Project Grants;RNA;Satiation;Services;Source;System;Technology;Time;transcriptome;transcriptome sequencing;United States National Institutes of Health;Universities;Validation;XCL1 gene

PROJECT_TITLE: Genomics, Bioinformatics, and Molecular Imaging Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Non-coding DNA sequences play crucial roles in gene regulation and the physical organization of the genome, with roles in development and consequences for disease. Using novel biophysical modeling and machine- learning approaches, this project will connect fundamental insights into 3D genome organization with the functional consequences of its disruption. These insights into genome organization will both aid in determining potentially pathogenic genetic variants, and open new frontiers in precision genome engineering.

PI_NAMEs: FUDENBERG, GEOFFREY  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: 3-Dimensional;Atlases;Automobile Driving;Bioinformatics;Biological Models;biophysical model;biophysical techniques;Cell Nucleus;cell type;Cells;Chromosome Structures;Chromosomes;Clinical;cohesin;Communication;Computer Models;Development;Disease;DNA;DNA Sequence;Engineering;Enhancers;frontier;Gene Expression Regulation;Genes;genetic information;Genetic Transcription;genetic variant;Genome;Genome engineering;genome-wide;Genomics;improved;in silico;Individual;insight;Learning;Machine Learning;Maps;Meiosis;meter;Methods;model building;Modeling;Molecular Mechanisms of Action;novel;novel strategies;Nucleotides;Pathogenicity;Play;promoter;Regulatory Element;Role;Synaptonemal Complex;Time;Tissues;Untranslated RNA;Variant

PROJECT_TITLE: Genomes in 3D: from maps to mechanisms

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Regenerative Medicine

PI_NAMEs: BELANCIO, VICTORIA PEREPELITSA (contact)

PROJECT_TERMS: Administrative Personnel;Administrator;Advisory Committees;Aging;career;career development;Centers of Research Excellence;Collaborations;Committee Members;Communication;Dedications;design;Development;Elements;Ensure;Environment;Evaluation;expectation;experience;Faculty;Fostering;Funding;Funding Mechanisms;Group Meetings;Growth;Interest Group;Measures;Mentors;multidisciplinary;next generation;novel;Participant;Phase;Pilot Projects;Preparation;Process;programs;Regenerative Medicine;Reproducibility;Research;Research Personnel;Resources;Scientist;Series;Structure;success;supportive environment;Talents;Technology;Time;Training;United States National Institutes of Health

PROJECT_TITLE: Pilot Projects Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE INST FOR BIOMEDICAL/CLINICAL RES

PHR: Alzheimer’s disease (AD), a severe progressive neurodegenerative disease of aging and the most common form of dementia, affects an estimated 30 million people worldwide. Here we propose to uncover genes and pathways causing and contributing to disease using models of AD and human post-mortem brain tissue. This in turn may ultimately lead to potential therapeutic interventions for the benefit of all those affected by AD.

PI_NAMEs: LIACHKO, NICOLE FARON (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: Acceleration;Affect;Aging;aging related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Amyloid beta-Protein;Amyotrophic Lateral Sclerosis;Autopsy;Behavioral;Biological Assay;Biology;Brain;Brain region;brain tissue;Caenorhabditis elegans;cerebral atrophy;Code;Cognitive;comorbidity;Data;Dementia;Disease;Exhibits;experience;Foundations;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Future;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;hippocampal sclerosis;Human;Impaired cognition;in vivo;Individual;Inherited;Intervention;loss of function mutation;Maps;model organism;Modeling;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;Neurofibrillary Tangles;neuroimaging;Neuronal Dysfunction;Neurons;neuropathology;neurotoxic;neurotoxicity;Neurotransmitters;new therapeutic target;Outcome;overexpression;Pathologic;Pathology;Pathway interactions;Patients;Persons;Phenotype;Process;protein aggregation;protein distribution;protein expression;protein TDP-43;Proteins;proteostasis;proteotoxicity;resilience;Resistance;response;RNA;RNA interference screen;Role;Senile Plaques;Stress;Surveys;synergism;tau aggregation;tau Proteins;TDP-43 aggregation;Testing;therapeutic development;Therapeutic Intervention;Toxic effect;transcriptome;transcriptome sequencing;transcriptomics;Transgenes;Transgenic Organisms;Work

PROJECT_TITLE: TDP-43 in Alzheimer's disease

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative Flexible coils improve patient comfort and can be formed into desired shapes to match the human anatomy of interest, exhibiting improved filling factor and signal-to-noise ratio, especially when imaging curved anatomies such as cervical spinal cord, pelvis, and hands. Although the challenges in building flexible coils have been solved, in practice, it is still an open question to make fully flexible coils since the balun or cable trap circuits associated with coils are still rigid and bulky. In this project, we propose a novel miniature (size as small as a chip capacitor, ~3×3×4 mm3) balun circuit that can be integrated with the coil’s feed circuit to realize fully flexible RF coils.

PI_NAMEs: YAN, XINQIANG  (contact)

PROGRAM_OFFICER_NAME: WANG, SHUMIN

PROJECT_TERMS: Affect;Amplifiers;Anatomy;Cervical spinal cord structure;Clinical;Communities;design;electric impedance;Electromagnetics;Elements;Exhibits;experimental study;flexibility;foot;Frequencies;Goals;Hand;Human;Image;Impairment;improved;interest;Knowledge;light weight;Magnetic Resonance Imaging;manufacture;Measures;Methods;microwave electromagnetic radiation;models and simulation;Noise;novel;Nuclear;Outcome;Patients;Pelvis;Performance;Phase;Polychlorinated Biphenyls;Printing;radio frequency;Series;Shapes;Signal Transduction;simulation;Structure;Temperature;Testing;Time;transmission process;Weight

PROJECT_TITLE: Miniature and integrable balun for light-weight and flexible MRI RF coils

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Proper formation of distinct types of neurons and glial cells in the central nervous system is essential for motor and intellectual function. The long-term goal of this project is to understand how oligodendrocyte lineage cells, which includes cells that wrap axons with insulating myelin, are produced by neural progenitors. Completion of the project aims will substantially extend our understanding of the molecular mechanisms that control formation of glial cells for myelination.

PI_NAMEs: APPEL, BRUCE H;FRANCO, SANTOS JOE (contact);SAGERSTROM, CHARLES G

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Axon;Biological Models;Brain;candidate identification;cell fate specification;Cell Lineage;cell type;Cells;Central Nervous System;Chromatin;Chromatin Modeling;Competence;Data;Development;developmental neurobiology;Disease;Dorsal;Epigenetic Process;experimental study;Failure;gain of function;Gene Expression;gene regulatory network;genetic approach;genetic manipulation;Genetic Transcription;gliogenesis;Goals;Health;Image;in vivo;Injury;insight;Knowledge;Learning Disabilities;loss of function;Maps;Mediating;Membrane;Mental disorders;migration;Modeling;Molecular;Motor;motor impairment;multiple omics;Mus;Myelin;myelination;Neocortex;nerve stem cell;Nervous System;Neural tube;neurogenesis;Neuroglia;Neurologic Dysfunctions;Neurons;notch protein;Notch Signaling Pathway;oligodendrocyte lineage;oligodendrocyte progenitor;Oligodendroglia;Pathway interactions;pharmacologic;precursor cell;Production;progenitor;programs;Prosencephalon;response;Role;SHH gene;Signal Transduction;single-cell RNA sequencing;smoothened signaling pathway;Specific qualifier value;Spinal Cord;stem cell fate specification;stem cells;Testing;transcription factor;Transcriptional Regulation;Work;Zebrafish

PROJECT_TITLE: Temporal and Spatial Control of Oligodendrocyte Fate Specification