ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Palliative Care;Parkinson's Disease;Primary Health Care;Rehabilitation;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Parkinson's disease (PD) and Lewy Body Dementia (LBD) are a chronic neurodegenerative illnesses which affect 1-2% of people over age 65 and are associated with disability, reductions in quality of life, caregiver distress, pain, fatigue, dementia and increased mortality. While PD and LBD are typically managed using a chronic disease model focused on motor symptoms such as tremor, palliative care offers an opportunity to improve quality of life for patients with PD/LBD and their family caregivers by addressing potential causes of suffering not well met in current models of care including advance care planning, non-motor symptoms such as pain, psychosocial issues, caregiver distress and spiritual needs. This proposal will build upon work by members of this research team to conduct a pragmatic clinical trial of a novel palliative care model for PD delivered through online communities for patients, caregivers and clinicians with the specific objectives of determining whether: a) this community-based intervention is effective to improve patient quality of life or caregiver distress; and b) this approach is feasible to disseminate palliative services more widely to PD patients and their families in the communities in which they live.

PI_NAMEs: KLUGER, BENZI M (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: accountable care organization;Address;Adoption;Adult;Advance Care Planning;Affect;American;burnout;Cancer Patient;career;Caregiver Burden;Caregivers;Caring;Cause of Death;Characteristics;Chronic;Chronic Disease;Clinical;combat;Communities;Community Healthcare;community intervention;comparative effectiveness trial;cost;Data;Databases;Dementia;disability;Disease;disease model;Distress;E-learning;Education;Effectiveness;effectiveness evaluation;end of life care;ethnic disparity;Family;Family Caregiver;family support;Fatigue;Foundations;Funding;Future;Grant;Health;Health Care Costs;health care service utilization;Health Personnel;health service use;Healthcare;High Prevalence;Hospitalization;human old age (65+);improved;Individual;innovation;interest;Intervention;Interview;Job Satisfaction;learning community;Letters;Lewy Body Dementia;Life;Linear Regressions;Maintenance;Malignant Neoplasms;Medical;medical specialties;meetings;member;Mental Depression;Modeling;Moods;mortality;motor symptom;Movement Disorders;Neurodegenerative Disorders;Neurologist;Neurology;non-motor symptom;novel;Nursing Homes;online community;online resource;Outpatients;Pain;palliative;Palliative Care;Parents;Parkinson Disease;Participant;Patient Care;patient mobility;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;peer;Persons;physical symptom;Physicians;Policy Maker;Population;Pragmatic clinical trial;Primary Care Physician;primary outcome;Progress Reports;Progressive Disease;Provider;Psychosocial Assessment and Care;Psychosocial Influences;Quality of life;racial disparity;randomized trial;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Resources;satisfaction;secondary analysis;secondary outcome;Services;Site;social disparities;Social support;Social Work;societal costs;Spiritual well-being;Spirituality;Symptom Burden;Symptoms;System;Teleconferences;telehealth;Testing;Time;Transportation of Patients;treatment as usual;treatment effect;Tremor;United States;Work

PROJECT_TITLE: More than a Movement Disorder: Applying Palliative Care to Parkinson's Disease and Lewy Body Dementias

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Project narrative The program proposed for this award focuses pushes the boundaries of label-free optical microscopy to build the foundation for a number of new molecular and functional imaging tools that will increases our understand- ing of biological processes and enable important advances in disease diagnosis and treatment. Thus, this work is ideally suited for NIGMS and MIRA.

PI_NAMEs: ROBLES, FRANCISCO E (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Award;Back;Biological;Biological Process;Biology;Cells;Classification;Complex;Computing Methodologies;cost;deep neural network;Detection;Disease;disease diagnosis;Foundations;Functional Imaging;Future;Goals;Image;image translation;Imaging Device;imaging modality;improved;innovation;Label;Laboratories;Lighting;Medicine;Methods;Microscopy;Molecular;molecular imaging;Morphology;National Institute of General Medical Sciences;novel;optical imaging;Optical Methods;Optics;Phase;Phenotype;programs;Pump;Research;Research Personnel;signal processing;software development;Spectrum Analysis;Staging;System;Techniques;Technology;technology development;tool;ultraviolet;Vision;Work

PROJECT_TITLE: Accessible label-free optical microscopy with quantitative molecular and functional contrast


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: The Training Program in Integrative Approaches to Explore Cellular Interactions in Neural Circuits prepares students to pursue research aimed at exploring the fundamental principles underlying the development and function of neural circuits using multidisciplinary approaches and rigorous methodologies. Basic research advances in deciphering the function of neural circuits will positively impact our understanding of a wide range of neurological disease that arise from either genetic or environmental perturbations, including neurodegenerative and neurodevelopmental disorders, epilepsy, peripheral neuropathies, and chronic pain.

PI_NAMEs: DASEN, JEREMY S (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: neural circuit


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Dynein is a microtubule-associated molecular motor that facilitates cargo transport and cellular division, which are both processes that are critical for cell survival. Mutations in dynein and proteins that regulate its activity lead to several diseases. This research will use an interdisciplinary approach to decipher dynein regulatory mechanisms, which has broad implications to human health and disease.

PI_NAMEs: DESANTIS, MORGAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: ATP Hydrolysis;Binding;Binding Proteins;Biochemistry;Cell division;Cell Nucleus;Cell Survival;Cytoplasm;Disease;Dynein ATPase;Epilepsy;Fluorescence Microscopy;Focal Adhesions;Functional disorder;genetic regulatory protein;Goals;Health;Human;interdisciplinary approach;Kinesin;Kinetics;Lead;live cell imaging;Mechanics;Mediating;Microcephaly;Microtubules;migration;Minus End of the Microtubule;Molecular;Molecular Motors;Motor;Movement;Mutation;Neurodegenerative Disorders;Neurodevelopmental Disorder;novel;Plus End of the Microtubule;Process;Proteins;Proteomics;Regulation;Research;Role;Schizophrenia;single molecule;structural biology;trafficking;Work

PROJECT_TITLE: Mechanisms of dynein regulation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Nutrition;Obesity

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE. Blood-borne, secreted polypeptides orchestrate endocrine communication between peripheral metabolic tissues. We have now developed a new methodology that enables the labeling, detection, and enrichment of these circulating proteins directly from blood plasma. We will further advance this technology to understand crosstalk between peripheral metabolic tissues and how those dysregulation of those endocrine pathways can lead to type 2 diabetes and other metabolic diseases.

PI_NAMEs: LONG, JONATHAN Z (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Animals;Area;Atlases;Blood;cell type;Chemicals;Chemistry;Collection;combat;Communication;Detection;Diabetes Mellitus;Diet;Endocrine;Event;Glucose;Goals;high reward;high risk;Homeostasis;In Vitro;in vivo;insight;intercellular communication;interest;Label;Lipids;Maps;Measures;Mediating;Metabolic;Metabolic Diseases;Methodology;Methods;Mus;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Organ;Orphan;Pathway interactions;Peripheral;Physical activity;Physiologic pulse;Plasma;polypeptide;Protein Secretion;Proteins;Resolution;Signal Pathway;Technology;Temperature;Tissues;Work

PROJECT_TITLE: Chemical interrogation of metabolic tissue crosstalk


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Genetics;Human Genome;Nanotechnology;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Wound Healing and Care

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Relevance of the proposed research project to public health The application addresses PA-20-185 goal as a Research Project Grant on new ways of treating stem cell and wound healing defects in diabetic corneal disease. We will focus on normalizing human diabetic corneal epithelial stem cells through the iPSC technology, as well as through a combination of nano and epigenetic therapy for maximum effect. If successful, the proposal may have a high impact for future treatment of frequent wound healing-related corneal problems in diabetic patients.

PI_NAMEs: LJUBIMOV, ALEXANDER V (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Age;Air;Back;bead chip;Bioinformatics;biomarker identification;Blindness;Cathepsins;Cell Therapy;Cells;Combined Modality Therapy;Complications of Diabetes Mellitus;Cornea;Corneal Diseases;corneal epithelial stem cells;corneal epithelial wound healing;corneal epithelium;Data;Decitabine;Defect;demethylation;design;Diabetes Mellitus;diabetic;diabetic patient;Diagnosis;Disease;DNA;DNA Methylation;Drug Combinations;effective therapy;Ensure;Epigenetic Process;epigenetic therapy;Epithelial Cells;epithelial stem cell;epithelial wound;Epithelium;Eye;Eye diseases;FDA approved;Functional disorder;Funding;Future;Gene Delivery;Gene Expression;gene therapy;gene-targeted therapy;Genes;Goals;Growth;Human;Impaired wound healing;Impairment;induced pluripotent stem cell;induced pluripotent stem cell technology;innovation;Iris;Keratopathy;Keratoplasty;Kinetics;Laboratories;lens;Lifting;limbal;Matrix Metalloproteinases;Membrane;methylation pattern;MicroRNAs;Molecular Structure;nano;nanoparticle;nanotherapy;Neuropathy;non-diabetic;novel;novel marker;novel strategies;Operative Surgical Procedures;Organ Culture Techniques;Outcome Measure;Pain;Pattern;pharmacologic;Pharmacotherapy;Phenotype;Population;progenitor;Property;protein expression;Proteins;Public Health Applications Research;Recurrence;Research Project Grants;Resolution;restoration;Retina;single-cell RNA sequencing;stem cell biomarkers;stem cells;stemness;Strategic Planning;Stratification;stromelysin 2;Surface;System;Tissue Model;Tissues;Toxic effect;transcriptomics;Transplantation;treatment optimization;Ulcer;Visual impairment;Western Blotting;wound healing

PROJECT_TITLE: Mechanisms of epithelial alterations in diabetic cornea

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: OLYMPIA

ORG_NAME: WA STATE DEPARTMENT OF AGRICULTURE

ORG_STATE: WA

PHR: PAR-20-105: Overall Component Project Narrative The Washington State Department of Agriculture (WSDA) Food Safety & Consumer Services (FS&CS) Laboratory has a history of demonstrated success as an awarded CAP member for FERN, MFRPS ISO, AFRPS, BSE, RRT, Produce Safety, USDA-MDP, beginning in 2000 to the present. As a CAP member, the laboratory actively participates in all activities associated with the Cooperative Agreements: sample collection, testing, proficiency testing, training seminars, conferences, face-to- face annual meetings, IT integration and method validation assignments. As an ISO17025:2005-2017 accredited laboratory, we’ve had a quality management system in place since 2011 with a dedicated quality assurance staff and procedures in place to assure good laboratory practices. We have laboratory facilities to assure the proper environment for advanced instrumentation in addition to secure sample custody and laboratory space. As a current FDA FERN, ISO and AFRPS cooperative agreement-funded laboratory, the laboratory is applying for five years of funding through the FDA Laboratory Flexible Funding Model (LFFM) Cooperative Agreement Program’s Discipline A Microbiology Track 2, 3, 4 and 5 and Discipline D Special Project Track 1, 2, 3 in order to enhance the capacity and capabilities of the laboratory in support of an integrated food safety system. The laboratory will participate in:  1. The use of various standardized cultural, biochemical and molecular analytical methods for the  detection and identification of foodborne pathogens in human and animal food (Discipline A  Microbiology Track 2 and 3). The laboratory will participate in human and animal food  sample analysis for surveillance assignments, food emergency outbreak testing, and ensure  large-scale food emergency event surge capacity by using various standardized cultural and  biochemical analytical methods for the detection and identification of pathogens. The WSDA  FS&CS Laboratory has trained staff and equipment to perform testing of pathogens as well as  serological analysis for Listeria monocytogenes (Poly O, Type 1 and Type 4), Escherichia coli  O157:H7 (O157 and H7), and E. coli STEC Big Six (all six O types).  2. Sequence using Whole Genome Sequencing for at least 100 isolates of pathogens.  The laboratory has the training and equipment to sequence and will upload sequences into  GenomeTrakr (Discipline A Track 4).  3. Gaining capacity for Cyclospora testing (Discipline A Track 5). The laboratory needs to gain  capacity by request of our food safety partners and to be a supportive member of the  integrated national laboratory system. The laboratory has worked hard to find funding to  support Cyclospora testing and was able to secure very small funding support to send its  microbiologists for a week long training at FDA Bothell in FDA BAM 19b Molecular Detection  of Cyclospora cayetanensis in Fresh Produce using Real-Time PCR method. We have some  equipment to support the test but we must purchase several more pieces, therefore we  require support.  4. The collection of samples (>1,000) (Discipline D Track 1). For decades, we have utilized  annual sampling agreements with our regulatory inspection partners. Our laboratory’s self-  sample collection history dates back to 2001 as a member of the USDA AMS Microbiological  Data Program (MDP) and for regulatory purposes. Training provided by USDA included  aseptic sampling technique, preserving sample integrity during transit, and maintaining  complete chain of custody documentation. Our sampling experience has only grown stronger  as a FDA FERN MCAP participant. For instance we collected over 3,600 samples in the last 2  years for testing by our FERN lab.  5. The integration of NFSDX-ORAPP systems with our data collection systems. We worked  closely with FDA for integrating our system to eLEXNET, so we desire to work on this new  integration. (Discipline D Track 2)  6. The Validation of a qPCR screening method for Salmonella in Foods (Discipline D Track 3).  We have decades of history validating methods under the USDA MDP, FERN MCAP, private  test manufacturers, as well as our own “Fit for Purpose” methods.  Washington State Department of Agriculture, Food Safety and Consumer Services Laboratory

PI_NAMEs: LIU, YONG  (contact)

PROGRAM_OFFICER_NAME: CHRYSOGELOS, CHRISTINA

PROJECT_TITLE: Enhancing the Capacity and Capability of Washington State Human and Animal Food Testing Laboratory in Support of an Integrated Food Safety System


ORG_CITY: MENANDS

ORG_NAME: WADSWORTH CENTER

PHR: PROJECT NARRATIVE The overarching goal of this proposal is to leverage the Wadsworth Center’s considerable laboratory capabilities and capacity as a world-class public health laboratory and research institute, coupled with its scientific expertise to create a first-class integrated Radiochemical, Microbiological and Chemical Testing Program for Food Defense and Capability Development that will serve the future needs of the FDA’s Food Emergency Response Network (FERN). Building on its current success as an FDA-FERN Cooperative Agreement laboratory for the Surveillance of Foods for Alpha, Beta, and Gamma Radioactivity; as an FDA Center for Food Safety and Applied Nutrition (CFSAN) Cooperative Agreement GenomeTrakr laboratory; and as a USDA Food Safety Inspection Service (FSIS) Cooperative Agreement laboratory for Microbiology and Chemistry Food Defense, the Wadsworth Center will provide key leadership, scientific expertise and analytical support to FERN under the proposed Laboratory Flexible Funding Model (LFFM).

PI_NAMEs: EGAN, CHRISTINA ;PARSONS, PATRICK J. (contact)

PROGRAM_OFFICER_NAME: WINTER, RONALD

PROJECT_TITLE: Wadsworth Center's Radiochemical, Microbiological and Chemical Testing for Food Defense and Capability Development


ORG_CITY: ALBANY

ORG_NAME: NY STATE DEPT OF AGRICULTURE/ MARKETS

PHR: NY AGM Division of Food Laboratory Project Narrative: The New York State Department of Agriculture and Markets (NY AGM) has a comprehensive food safety inspection program and regulatory food safety testing laboratory. The Division of Food Laboratory is willing and able to engage with the national food safety system initiative by (1) participating in, and passing, annual chemistry and microbiology food related proficiency tests offered through a suitable proficiency testing program; (2) participating in small-scale chemistry and microbiology food testing related method development, method validation research, and matrix extension research, as requested by the FDA; (3) providing chemistry and microbiology food testing related training and mentorship to other state laboratories, as requested; (4) continuing to be a FERN member; (5) participating in annual LFFM face-to-face meeting; (6) maintaining ISO/IEC 17025 accreditation to ensure quality assurance and quality control testing; (7) maintaining laboratory facilities and personnel necessary to complete regulatory activities; (8) providing notifications, summaries and reports to FDA, as requested and required; (9) engaging NY AGM inspectors to collect regulatory food samples and ensure they maintain best practices when sampling FDA food regulatory products; (10) notifying the FDA project manager and the technical lead within one (1) business day of any presumptive positive or “cannot rule out” (CRO) food samples, (11) submitting a full laboratory package for any confirmed positive or violative food sample, as required; (12) maintaining a confidentiality agreement with FDA as a valid 20.88; (13) participating annually in at least one FDA requested assignment related to food testing; (14) providing an outline plan on how the laboratory will sequence genomes and upload data in real-time to NCBI-NIH curated national database for enteric pathogens; and (15) providing outline plans for Chemistry and Microbiology Capability/Capacity Development and for Special Projects (Sample Collection, NFSDX and ORAPP Integration, and Method Development/Validation).

PI_NAMEs: ISHIDA, MARIA LUCIA (contact)

PROJECT_TITLE: NYS AGM Food Laboratory - Laboratory Flexible Funding Model (LFFM) (U19)


ORG_CITY: WATERBURY

ORG_NAME: VERMONT STATE AGENCY OF HUMAN SERVICES

ORG_STATE: VT

PHR: NARRATIVE The Vermont Farm to Plate Network’s Rooted in Vermont grassroots initiative has increased locally sourced food purchases from 6.9% in 2010 to 12.9% in 2018 (representing more than $289 million in local food sales) and aims to mainstream local food consumption in Vermont during the next decade. At the same time, the Centers for Disease Control and Prevention (CDC) estimates that 1 in 6 Americans (or 48 million people) get sick, over 128,000 are hospitalized, and 3,000 die from contaminated foods or beverages each year and the United States Department of Agriculture (USDA) estimates that these foodborne related illnesses cost over $15.6 billion dollars each year. The Vermont Department of Health Laboratory (VDHL) attained ISO/IEC 17025 accreditation in September 2016 and is the primary serving laboratory for the VDH Manufactured Food Regulatory Program Standards (MFRPS) and is seeking funding to maintain and enhance its ISO/IEC 17025 accreditation, increase its microbiological and radiochemical food sample testing capacity and capabilities, increase its data sharing and surveillance capabilities, and overall capacity to protect Vermonters from unsafe food supplies.

PI_NAMEs: EISENHAUER, JESSICA MENDES (contact)

PROJECT_TITLE: VDH Laboratory Food Testing Capability and Capacity Enhancement Project


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative The rise of high-throughput genomic profiling of individual cells and efficient, targeted manipulation of cellular phenotypes (including CRISPR-based genetic perturbations) promise to revolutionize our understanding of cellular biology and disease. However, realizing this revolution will require new computing paradigms that can integrate and analyze these massive datasets and suggest new biological hypotheses and experimental designs. Here we develop novel computational algorithms and software for tackling these challenges to characterize cellular diversity and improve our ability to manipulate cells to understand and treat disease.

PI_NAMEs: BERGER, BONNIE  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Active Learning;Algorithm Design;Algorithms;Big Data;Biological;Biology;Biotechnology;cell growth;Cells;Cellular biology;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;Computational algorithm;Computer software;computing resources;Data;Data Set;design;Development;Dimensions;Disease;Experimental Designs;experimental study;Feedback;Genes;Genetic;genomic data;genomic profiling;Genomics;Heterogeneity;high dimensionality;High-Throughput Nucleotide Sequencing;improved;Individual;insight;interest;Machine Learning;machine learning framework;Measures;Memory;Modeling;multimodality;multiple omics;Mutation;novel;Outcome;Pathologic;Performance;Phenotype;precision medicine;Property;Proteomics;Secure;small molecule;Software Tools;Spatial Design;State Interests;structural biology;Systems Biology;Time;Tissues;transcriptomics;Translating;Uncertainty;Untranslated RNA;Validation;Work

PROJECT_TITLE: Manifold representations and active learning for 21 st century biology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: CHAMPAIGN

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: The proposed research is relevant to human health and NIH mission because it is expected to uncover conserved principles and molecular pathways for developmental timing control in neural progenitors to generate neural diversity. It will provide novel insights to fundamental mechanisms coordinating growth/proliferation and lineage differentiation in neural stem cells.

PI_NAMEs: LI, XIN  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Age;ATAC-seq;Binding;Binding Sites;Biological Assay;Birth Order;brain abnormalities;Cell Cycle;Chromatin;Chromatin Remodeling Factor;Complex;Cortical Cord;Data;Development;developmental disease;Drosophila genus;Enhancers;Epigenetic Process;experimental study;gene regulatory network;Generations;Genes;genetic analysis;Genetic Transcription;Growth;Health;Human;insight;Invertebrates;Metabolism;Mission;Molecular;mutant;Mutate;nano;nerve stem cell;neural;neural patterning;neuroblast;notch protein;novel;Nuclear;Organism;Pathway interactions;Pattern;Phenotype;Play;Process;progenitor;Proliferating;recruit;Regulation;Reporter;Repression;Research;Retina;Role;Series;Shapes;Signal Transduction;single-cell RNA sequencing;Specific qualifier value;Speed;Spinal Cord;Testing;transcription factor;transcription regulatory network;Transcriptional Regulation;United States National Institutes of Health;Vertebrates

PROJECT_TITLE: Temporal Patterning of Neural Progenitors to Generate Neural Diversity

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


NIH_SPENDING_CATS: Brain Disorders;Disability Research;Intellectual and Developmental Disabilities (IDD);Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Narrative It has been estimated that neurodevelopmental disabilities (NDDs) affect at least 10% of all families in the USA. A new generation of multidisciplinary investigators are urgently needed who will be able to apply cutting-edge research approaches and new technology to elucidate mechanisms underlying the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be developed. The major objective of our NDD training program – the DC NDD T32 Training Program - is to fill this need by leveraging on all resources available at our institutions in the District of Columbia and at our DC-IDDRC. We have been successful in training several generations of investigators in research that will advance our understanding of NDDs, and the proposed program will support training and career development of new investigators by providing 3 years of coaching and experience under the direction of a highly qualified investigator/mentorship team.

PI_NAMEs: HAYDAR, TARIK F (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Disability research;District of Columbia;Neurodevelopmental Disability

PROJECT_TITLE: District of Columbia T32 on Neurodevelopmental Disabilities Research (DC NDD T32)


ADMINISTERING_IC: AI

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_NAME: NOVOBIOTIC PHARMACEUTICALS, LLC

PHR: Narrative Tuberculosis continues to be a leading cause of death worldwide and the second leading infectious killer after Covid-19. In 2020, an estimated 10 million people became ill and 1.5 million died (including 214,000 co-infected with HIV) from tuberculosis. The purpose of this project is to develop the new antibiotic, teixobactin, to treat tuberculosis.

PI_NAMEs: HUGHES, DALLAS  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Agreement;Animal Model;Animals;Anthrax disease;Antibiotics;Antitubercular Antibiotics;arm;Bacteremia;bactericide;Binding;Blood;C3HeB/FeJ Mouse;Cause of Death;cell killing;Cell membrane;Cell Wall;Chronic;Code;Collaborations;comparative efficacy;COVID-19;Development;Development Plans;Disease;DNA;Dose;Drug Combinations;Drug Exposure;Drug Kinetics;Drug resistance;Drug resistance in tuberculosis;efficacy study;efficacy testing;Epithelium;Exhibits;extensive drug resistance;Fermentation;global health;Goals;Gram-Positive Bacteria;high risk;HIV;Human;In Vitro;Infection;Infectious Agent;Infectious Skin Diseases;Inhalation Therapy;Intranasal Administration;Intravenous;Investigational Drugs;isoniazid;Lesion;Linezolid;Lipid III;Lipids;Liquid substance;Lung;lung lesion;Membrane;methicillin resistant Staphylococcus aureus;microbial;Modeling;Molecular Structure;mouse model;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;multiple drug use;muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol;Mus;mutant;Mycobacterium tuberculosis;Necrosis;non-compliance;non-invasive monitor;novel antibiotic class;Oral;Oral Tuberculosis;Oryctolagus cuniculus;pathogen;Patient Noncompliance;Patients;Persons;Pharmaceutical Preparations;Phase;Plasma;Pneumonia;pneumonia model;pre-Investigational New Drug meeting;preclinical development;Primary Infection;Production;Property;pulmonary granuloma;Pulmonary Pathology;Pulmonary Tuberculosis;Pyrazinamide;Regimen;Relapse;Resistance;Resistance development;resistant strain;Route;side effect;Site;Skin;Streptococcus pneumoniae;Structure;synergism;Teichoic Acids;Testing;Time;Toxic effect;treatment duration;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Universities;X-Ray Computed Tomography

PROJECT_TITLE: Teixobactin Development for Tuberculosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-C(12)]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: OVERALL NARRATIVE The Institute for Translational Medicine and Therapeutics is the academic home for the CTSA in Penn. For the past decade the specific aims of ITMAT have been and remain (i) to increase the number of investigators capable of pursuing their research between proof of concept in cells and model systems and (ii) elucidation of the mechanisms of human physiology, disease or drug action through intense phenotyping in small numbers of people.

PI_NAMEs: FITZGERALD, GARRET A (contact)

PROGRAM_OFFICER_NAME: CURE, PABLO

PROJECT_TERMS: Adult;Biological Models;Cells;Childhood;Clinical and Translational Science Awards;clinical implementation;Clinical Sciences;Democracy;Discipline;Disease;drug action;Education;Fostering;Funding;Growth;Home;Human;Institution;novel;Persons;Phenotype;Physiology;programs;recruit;Research;Research Personnel;Resources;Science;translational medicine;Translational Research;translational therapeutics

PROJECT_TITLE: Institutional Clinical and Translational Science Award


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative Enduring cognitive and emotional difficulties are frequently reported as factors reducing quality of life by individuals living with a traumatic brain injury (TBI). The proposed study will investigate the impact of altered endocytosis on synaptic vesicular recycling and neurotransmission that contribute to impaired synaptic function after a TBI. Successful completion of this project will provide bridge an important knowledge gap in understanding the detrimental effects of TBI on the synapse and identify endocytosis as a novel therapeutic target to promote recovery of synaptic and cognitive function after a TBI.

PI_NAMEs: CARLSON, SHAUN  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: 3-Dimensional;Acute;Attention;Attenuated;Biological Assay;Blast Injuries;Brain;Brain Injuries;Cell membrane;Chronic;Clathrin;Clathrin Heavy Chains;Clathrin Light Chains;Cognition;Cognitive;cognitive function;Computer Models;controlled cortical impact;Data;density;Development;Disease Pathway;Docking;Emotional;Endocytosis;Event;Female;Fluorescence;Functional disorder;gene network;Genes;genetic signature;Glutamates;Hippocampus;Homeostasis;immunoreactivity;Impaired cognition;Impairment;improved;Individual;Injury;innovation;Knowledge;Laboratories;Learning;Light;liquid chromatography mass spectrometry;male;Maps;Measures;Mediating;Membrane;Memory;Memory impairment;Microscopy;Modeling;Molecular;neurobehavioral;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;new therapeutic target;novel;Pathology;Pathway interactions;Patients;Pharmacology;Play;Potassium;preclinical study;Proteins;Quality of life;Rattus;Recovery;Recovery of Function;recruit;Recycling;Reporting;restoration;Role;Severities;sex;single-cell RNA sequencing;Sorting;spatial memory;Structure;Synapses;synaptic function;Synaptic Vesicles;Synaptosomes;System;targeted treatment;Techniques;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Traumatic Brain Injury;Vesicle;Viral;Viral Vector;Work

PROJECT_TITLE: Synaptic Vesicular Alterations after Traumatic Brain Injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Princeton

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative We aim to develop new technology to quantitatively analyze thousands of proteins in a single experiment, which will be widely beneficial to studying biological systems in health and diseases. We will apply these techniques to study how proteins partition between the nucleus and cytoplasm and to measure how proteins are degraded. This study will provide us with insight into how healthy and diseased cells control their protein abundance levels and determine protein subcellular localization.

PI_NAMEs: WÜHR, MARTIN  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Active Biological Transport;Address;Behavior;Biochemical;biological systems;Biology;Cell Nucleus;Cells;cost;Cytoplasm;Data;data quality;Democracy;Development;Diffusion;Disease;Embryo;experimental study;Genes;Genetic Transcription;Goals;Health;Human Genome Project;improved;insight;interest;mass spectrometer;Measurement;Measures;Methods;Modeling;new technology;Nuclear Pore;Organism;Property;protein degradation;protein expression;Proteins;Proteome;Proteomics;Regulation;Research;Shotguns;System;Techniques;Technology;Time;Translations;zygote

PROJECT_TITLE: Development of New Proteomics Technology and its Application to Study Cellular Organization

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_CITY: AUSTIN

ORG_NAME: TEXAS STATE DEPT OF HEALTH SERVICES

ORG_STATE: TX

PHR: Project Narrative Enhancing the Capacity and Capability of Human Food and Environmental Testing Laboratory  in the Texas Department of State Health Services  With this new funding opportunity, the Texas Department of State Health Services (DSHS) Laboratory Services Section (LSS) intends to use funds to maintain and build our capabilities and capacity for microbiological, radiochemistry and chemistry-based food testing and emergency response to be utilized in Texas as well as nationally to improve the overall safety of our food supply and subsequently the public’s health. Expanding the capabilities to include Cyclospora detection in food, adding qPCR screening for Salmonella in foods and environmental as well as adding allergen and other chemistry analyses will enable rapid detection of increasing threats to the food supply. In addition to improving DSHS ability to monitor and respond to food supply threats, this cooperative agreement will enhance collaborations with our federal partners and improve data exchange.

PI_NAMEs: SCHROEDER, CASEY ;TANKSLEY, SUSAN  (contact)

PROJECT_TITLE: Enhancing the Capacity and Capability of Human Food and Environmental Testing Laboratory at the Texas Department of State Health Services: Overall


ORG_CITY: RENO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: NEVADA STATE PUBLIC HEALTH LABORATORY NARRATIVE PROJECT NARRATIVE Expanding and enhancing the NSPHL’s food testing capacity and capability will not only provide additional information to regulatory officials; but will also allow broad hazard screenings of foods providing a structure that promotes prevention of illness. Page 1 of 1

PI_NAMEs: VAN HOOSER, STEPHANIE  (contact)

PROJECT_TITLE: Laboratory Food Surveillance, Maintenance and Capacity Enhancement - 5 Year


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: Project Narrative Since 2016, North Carolina State University has participated in the Food and Drug Administration GenomeTrakr program and helped expand the program on a global scale. The aim of this project is to enhance surveillance of bacterial pathogens associated with foodborne illness at the national and global level across human, animal and environmental sectors. This will help identify new, clinically relevant bacterial strains to safeguard US and global food safety and public health.

PI_NAMEs: THAKUR, SIDDHARTHA  (contact)

PROJECT_TITLE: Enhance the surveillance of foodborne bacterial pathogens isolated from food and environmental samples using whole genome sequencing (WGS) to prevent foodborne outbreaks and promote public health


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BOSTON

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Much of the focus in biomedical science today concerns failures of regulatory circuits that control proliferation, growth, and maintain homeostasis. Two of the most important are the Wnt pathway, prominent in cell differentiation and cancer, and cell size control, important in bridging physiology with growth. We use several new methods including new forms of microscopy and biochemistry to understand these pathways in mechanistic chemical terms with the hope of appreciating their normal function and addressing underlying pathologies.

PI_NAMEs: KIRSCHNER, MARC WALLACE (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Address;Biochemistry;Biological Assay;Biology;Cell Cycle;Cell Differentiation process;cell growth;Cell Physiology;Cell Size;Cells;Chemicals;Chimeric Proteins;Complex;Computers;Coupled;Cryoelectron Microscopy;Cultured Cells;Development;Developmental Gene;Disease;Dryness;Enzymes;Event;Failure;Feedback;fluorescence imaging;Future;Growth;Growth Factor;Homeostasis;In Vitro;Kinetics;Lipids;Malignant Neoplasms;Mammalian Cell;mathematical model;Measures;Metabolism;Methods;Microscopy;Mus;Nutrient;Nutritional;Organ;Pathology;Pathway interactions;pharmacologic;Phase;Physiological;Physiology;Positioning Attribute;preservation;Proliferating;Property;Protein Biosynthesis;protein degradation;protein purification;Proteins;Raman Spectrum Analysis;response;scaffold;Science;single molecule;Structure;System;Time;Tissues;tool;Transcriptional Regulation;WNT Signaling Pathway

PROJECT_TITLE: The dynamics and underlying mechanisms controlling cell size and canonical Wnt signaling


NIH_SPENDING_CATS: Brain Disorders;Neurosciences

PHR: Narrative Brain Injury Training Grant The continuing aim of the Brain Injury Training Grant (BITG) is to provide an excellent mentoring environment for highly motivated clinician and basic scientists to prepare them for careers in nervous system injury research. We request continued funding for 4 post-doctoral training slots (simultaneous) for individuals with a strong interest in studying injury to the nervous system who will train within a broader program. These positions are anticipated to be filled by a combination of neurosurgical residents (during their strictly protected research training) and highly qualified Ph.D. graduates.

PI_NAMEs: SMITH, DOUGLAS HAMILTON (contact)

PROJECT_TERMS: Brain Injuries;Grant;Training

PROJECT_TITLE: Brain Injury Training Grant


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE SCA1 is fatal neurodegenerative disease caused by the expansion of polyglutamine repeats in ataxin-1(ATXN1) protein. Some SCA1 patients develop cognitive deficits that impact their daily life but are little understood. The proposed research will increase our understanding of anatomical substrates for cognitive decline in SCA1 and will inform the development of effective cognitive therapies.

PI_NAMEs: CVETANOVIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Anatomy;ataxin-1;Brain;Brain region;cell type;Cells;Cerebellar Diseases;Cerebellum;Chronic;Cognition;Cognitive;Cognitive deficits;cognitive function;cognitive testing;Cognitive Therapy;conditioned fear;Data;Development;Discrimination;Disease;effective therapy;Electrophysiology (science);Enterobacteria phage P1 Cre recombinase;Etiology;Exhibits;experimental study;Functional disorder;Human;imaging approach;Impaired cognition;Investigation;Knock-in Mouse;Life;Location;LoxP-flanked allele;Molecular;Morphology;motor deficit;motor impairment;mouse model;Movement;Mus;mutant;Neurocognitive Deficit;Neurodegenerative Disorders;Neurologic Dysfunctions;Neurons;novel;Pathogenesis;Pathology;Patients;Phenotype;Play;polyglutamine;Prefrontal Cortex;Proteins;public health relevance;Purkinje Cells;Quality of life;Research;Reversal Learning;Role;Slice;Testing;therapeutic development;timeline;Transgenic Mice;Transgenic Organisms;Type 1 Spinocerebellar Ataxia

PROJECT_TITLE: Etiology of cognitive decline in Spinocerebellar ataxia type 1

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: OVERALL PROJECT NARRATIVE The remarkable progress that has been made within the past decade in the treatment of advanced melanoma has been based on a deep understanding of biology and has resulted in unprecedented clinical benefits. Further understanding of mechanisms of response and resistance and uncovering specific cancer vulnerabilities, will enable the development of improved therapies. We anticipate that the knowledge gained from this program project grant and its three research projects will provide benefits to patients with other cancers. 1

PI_NAMEs: RIBAS, ANTONI  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: addiction;Address;anti-PD-1;anti-PD1 therapy;Antigen Presentation Pathway;Back;Bioinformatics;Biological Models;Biology;BRAF gene;Caspase;Cell Death;Clinic;Clinical;clinical translation;Clinical Trials;Collaborations;combinatorial;Combined Modality Therapy;Communities;cytokine;Databases;design;Development;epigenomics;Exclusion;Experimental Models;Genomics;Goals;Immune;immune checkpoint blockade;Immune Targeting;Immunotherapy;improved;in vivo;inhibitor;innovation;Institute of Medicine (U.S.);Interferon Type II;Iron;Knowledge;Learning;Letters;Malignant Neoplasms;MAP Kinase Gene;MEKs;Melanoma;Mitogen-Activated Protein Kinase Inhibitor;Modeling;Molecular;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;new combination therapies;next generation;novel;novel therapeutics;Organ;patient derived xenograft model;Patients;PD-1 blockade;Pharmaceutical Preparations;Phenotype;pre-clinical;Pre-Clinical Model;prevent;Program Research Project Grants;programs;Published Comment;Rationalization;Research;research clinical testing;Research Project Grants;Resistance;resistance mechanism;response;Sampling;Signal Transduction;Site;statistics;synergism;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Tissues

PROJECT_TITLE: Combination Therapies to Defeat Melanoma Resistance


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Skin Cancer

PHR: PROJECT 1 PROJECT NARRATIVE Therapeutic resistance is the rule rather than the exception and strongly limits the clinical benefits of recently introduced “breakthrough” treatments for advanced melanoma. Translating cancer research into patient survival depends on a deep understanding of resistance mechanisms to clinically active therapies. As RAF/MEK and PD-1/CTLA-4 therapies were first developed in patients with advanced melanoma, overcoming resistance to these therapies has wide-reaching implications for cancer treatments in general.

PI_NAMEs: LO, ROGER S (contact)

PROJECT_TERMS: Acceleration;addiction;Agonist;anti-cancer research;anti-CTLA-4 therapy;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;Antibodies;Biological Markers;Biology;cancer therapy;Cell Death;Cell Death Induction;Cell Line;Cells;Chromatin;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collaborations;combinatorial;Combined Modality Therapy;Correlative Study;CTLA4 gene;Cytoplasm;Data;Dermatology;design;dimer;DNA Repair;Dose;Evolution;exome;Exposure to;Generations;Genome;Human;human subject;immune checkpoint;immune checkpoint blockade;immune resistance;immunogenic cell death;Immunotherapy;improved;in vivo;inhibitor;insight;investigator-initiated trial;Joints;Laboratories;Letters;Life;MAP Kinase Gene;Measures;MEKs;Melanoma;Melanoma Cell;methylome;Modeling;Monitor;Multiomic Data;multiple omics;Mutation;Natural Immunity;neoplastic cell;next generation;Nivolumab;Oncology;participant enrollment;Pathway interactions;patient derived xenograft model;Patients;PD-1 inhibitors;pharmacologic;Phase;phase 2 study;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;potential biomarker;preclinical study;preclinical trial;predictive marker;prevent;programmed cell death protein 1;Proteome;Protocols documentation;Publications;Reagent;Refractory;Regimen;research clinical testing;Resistance;Resistance development;resistance mechanism;response;Rotation;Safety;Sampling;single-cell RNA sequencing;small molecule inhibitor;standard of care;Stimulator of Interferon Genes;synergism;targeted treatment;Technical Expertise;Testing;therapy resistant;Tissues;transcriptome;Translating;tumor;tumor microenvironment;Withdrawal

PROJECT_TITLE: Project 1:  Strategies to enhance MEK inhibitor efficacy in MUTNRAS melanoma


PHR: PROJECT 2 PROJECT NARRATIVE Immunotherapy and targeted therapeutics are having major impact on melanoma treatment. Nonetheless, in many patients resistance arises as these treatments drive melanomas towards aggressive, resistant subtypes, such as dedifferentiated variants. We have discovered a new Achilles heel for dedifferentiated melanomas related to their sensitivity to oxidative stress, and are pursuing co-treatment therapies that would prevent dedifferentiation-based resistance.

PI_NAMEs: GRAEBER, THOMAS G (contact)

PROJECT_TERMS: Address;anti-PD-1/PD-L1;Antitumor Response;Apoptosis;Automobile Driving;Biological Models;Biometry;BRAF gene;Buffers;cancer cell;Caring;Cell Death;Cell Death Process;cell dedifferentiation;Cell Line;Cells;Classification;Clinical;Clinical Trials;Collaborations;Combined Modality Therapy;Complement;CTLA4 gene;cytokine;Data;Data Set;Drug Targeting;efficacy testing;Epigenetic Process;experience;experimental study;genetic approach;Genetic Transcription;Genomics;Goals;Human;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;immunogenic;Immunotherapy;Inflammation;inhibitor;inhibitor therapy;insight;Interferons;Iron;iron metabolism;kinase inhibitor;Knowledge;Link;lipid metabolism;lipidomics;Lipids;MAP3K1 gene;Mediating;MEKs;Melanins;melanocyte;Melanoma;Melanoma Cell;Metabolism;metabolomics;Metastatic Melanoma;Modality;Modeling;Modernization;mouse model;Mutate;Neural Crest;new therapeutic target;Oxidation-Reduction;Oxidative Stress;patient derived xenograft model;Patients;PD-1/PD-L1;Pharmaceutical Preparations;Pharmacogenomics;pharmacologic;Phosphotransferases;pre-clinical;Pre-Clinical Model;prevent;Process;Production;programs;Proto-Oncogene Proteins B-raf;Publications;Publishing;Regulation;Relapse;Research Personnel;Resistance;Resistance development;resistance mechanism;Role;Route;Sampling;Signal Transduction;standard of care;statistics;Stress;Structure;targeted treatment;Testing;Therapeutic;therapy resistant;treatment strategy;tumor;two-dimensional;Undifferentiated;Validation;Variant

PROJECT_TITLE: Project 2:  Targeting differentiation-linked redox sensitivity in melanoma


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAINT LOUIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Denervation of skeletal muscle from traumatic or iatrogenic injuries causes devastating and often permanent disability. Full function is rarely recovered, but given the uncertain nature of peripheral nerve recovery, the independent effects of increasing degrees of nerve injury on muscular atrophy are not well understood. This project seeks to characterize the effects of increasing degree of nerve injury on muscular atrophy and better visualize this process in real time utilizing calpain sensitive custom designed optical probes.

PI_NAMEs: BROGAN, DAVID MICAH (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Affect;AKT Signaling Pathway;Animal Model;Assessment tool;Atrophic;axon injury;Biological;Biological Assay;bone imaging;Calpain;Caring;Cells;Clinical;clinical translation;Crush Injury;Custom;Data Correlations;Denervation;depolymerization;design;Desmin;diagnostic tool;differential expression;Early Intervention;Enzyme-Linked Immunosorbent Assay;Evaluation;Event;ex vivo imaging;Excision;experience;Experimental Designs;Feedback;Female;Fibrosis;Filament;Fluorescence;Fluorescent Probes;Functional disorder;Functional Imaging;functional outcomes;Future;Genetic Transcription;Goals;Grant;Hamsters;Hand Strength;Health;Hindlimb;Hippocampus;iatrogenic injury;Image;imaging probe;imaging system;improved;improved outcome;In Vitro;in vivo;in vivo imaging;Injectable;Injections;Injury;insight;interest;Investigation;Journals;Lesion;Lifelong disability;Limb structure;Literature;male;Mediating;Mediator;Mentors;Methodology;Methods;Modeling;Molecular;Molecular Biology;molecular marker;Molecular Probes;Molecular Target;mouse model;Mus;Muscle;Muscle denervation procedure;Muscular Atrophy;Musculoskeletal;Myofibrils;Myogenin;Nature;Near-infrared optical imaging;Nerve;Nerve Crush;nerve injury;nerve repair;nerve transection;Neuregulins;neuromuscular;novel;novel diagnostics;Operative Surgical Procedures;optical imaging;Optics;Orthopedics;Outcome;Pathway interactions;Patients;Penetration;Peptide Hydrolases;Peripheral Nerves;PI3K/AKT;preclinical imaging;predictive marker;Process;Prognosis;protein aminoacid sequence;Proteins;Recovery;Recovery of Function;repaired;Reporting;Research;Research Methodology;Resected;Resources;response;restoration;Role;sciatic nerve;Scientist;Secondary to;Series;Severities;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;skills;stem;Surgeon;System;Techniques;Technology;Testing;Time;time interval;tool;Training;transcription factor;Translations;Trauma;Traumatic injury;Up-Regulation;Visualization;Walking;Wallerian Degeneration;Work;Writing

PROJECT_TITLE: Identification and Imaging of Skeletal Muscle Response to Graded Nerve Crush

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Clinical Research;Data Science;Dental, Oral, and Craniofacial Disease

PI_NAMEs: MEAGHER, EMMA ANNE (contact)

PROJECT_TERMS: Address;Appointment;Articulation;Award;Basic Science;Big Data;biomedical informatics;career;career development;Career Mobility;certificate program;Clinical Competence;Clinical Sciences;clinical translation;Collaborations;Complex;Consent;COVID-19;Data;Data Science;Degree program;Dentistry;design;Desire for food;Discipline;Discipline of Nursing;diversity and inclusion;drug development;Education;Educational Activities;educational atmosphere;Educational Curriculum;Engineering;Environment;Ethical Issues;experience;externship;Faculty;flexibility;Funding;Generations;Goals;Grant;health care quality;Healthcare;Hospital Design;implementation science;improved;Industrialization;Industry;innovation;Institution;Internships;Knowledge;Leadership;Master of Science;medical schools;Mentors;Mentorship;Mission;multidisciplinary;National Center for Advancing Translational Sciences;next generation;Patient Care;Patients;Peer Review;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Publishing;recruit;Regulation;remote health care;Research;Research Personnel;Research Training;Resources;Review Literature;Science;science education;Scientist;segregation;Series;Site;skill acquisition;Strategic Planning;Structure;Students;success;Supervision;symposium;Teacher Professional Development;Technology;Testing;Therapeutic;TNFSF15 gene;Training;Training and Education;training opportunity;Training Programs;Translational Research;translational therapeutics;vaccine development;Veterinary Medicine;Workforce Development

PROJECT_TITLE: Institutional Career Development Core


ORG_CITY: LOS ANGELES

PHR: PROJECT 3 PROJECT NARRATIVE In the new era of cancer immunotherapy becoming standard of care and often the preferred frontline therapy for several cancers, it is of key importance to understand why some patients never respond to this mode of therapy, and how some patients respond and then progress. If we understand these processes at the mechanistic level we can then rationally design approaches to prevent or treat resistance to cancer immunotherapy in patients with advanced melanoma, with applicability to many other cancers. 1

PROJECT_TERMS: Activated Natural Killer Cell;Adoptive Transfer;Agonist;Animals;Antibodies;Antigen Presentation;Award;Bioinformatics;Biology;Biometry;Biopsy;cancer cell;cancer immunotherapy;Cell Line;Cells;Chemosensitization;Clinical Trials;Collaborations;Combined Modality Therapy;CRISPR/Cas technology;Data;Epigenetic Process;Exclusion;Gene Expression;Genetic;genetic resistance;Goals;Human;Immune;Immunotherapy;improved;In Vitro;in vivo Model;inhibitor;Interferon Activation;Interferon Receptor;Interferon Type II;Interferons;JAK1 gene;JAK2 gene;Knock-out;Knowledge;Laboratories;Laboratory Research;Learning;loss of function;loss of function mutation;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Minority;Modeling;Molecular;Molecular Biology;mouse model;Mus;Mutation;Natural Killer Cells;Nivolumab;non-genetic;participant enrollment;Pathologic;Pathology;Pathway interactions;Patient Care;Patients;pharmacologic;Phosphotransferases;Positioning Attribute;prevent;Process;programs;rational design;Reagent;Reporting;Research;Research Personnel;Resistance;resistance mechanism;Resistance Process;response;Role;Sampling;standard of care;statistics;T-Lymphocyte;targeted treatment;Testing;therapy resistant;Tissues;Toll-like receptors;tumor

PROJECT_TITLE: Project 3:  Modeling and overcoming resistance to melanoma immunotherapy


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Skin Cancer

PROJECT_TERMS: Administrative Coordination;Bioinformatics;Biometry;Biostatistics Core;Budgets;Clinical Research;Clinical Trials;Combined Modality Therapy;Communication;Comprehensive Cancer Center;Computer software;conflict resolution;Consultations;Contracts;daily functioning;Data;data management;design;Development;Ensure;Evaluation;Experimental Designs;Fostering;Goals;Government;Grant;Infrastructure;Knowledge;Laboratory Study;Leadership;Manuscripts;Mediating;meetings;Melanoma;Methodology;Minority;Monitor;mouse model;Mus;Occupational activity of managing finances;Policies;Preparation;Program Efficiency;programs;Progress Reports;prospective;Protocols documentation;Publications;Quality Control;Records;recruit;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Resistance;Resource Sharing;Role;Sample Size;Sampling;Schedule;Science;Scientific Advances and Accomplishments;Services;Statistical Data Interpretation;statistics;Supervision;Technology;Training;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Administrative and Statistics Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Skin Cancer

PHR: CORE B PROJECT NARRATIVE The proposed projects of this PPG seek to understand the molecular and cellular basis for mechanisms and resistance to targeted therapy or checkpoint inhibitors to allow the rational design of combinatorial therapies that treat and eventually prevent resistance. These studies rely heavily on patient-derived samples collected both at UCLA and provided by outside collaborators through the Biospecimen Repository and Processing Core (BRPC). Core B will serve for obtention, generation, and authentication of biomaterial (tissue and biofluid) from patient samples; as well as provide advanced expertise in melanoma biology, cell line development, pathologic interpretation and biorepository management for all proposed studies.

PI_NAMEs: COMIN-ANDUIX, BEGONYA  (contact)

PROJECT_TERMS: Ambulatory Care Facilities;Animals;Antibodies;biobank;Biocompatible Materials;Biological Specimen Banks;Biological Specimen database;Biology;Biopsy;BRAF gene;Cell Line;Cells;Chromium;Clinical Data;clinically relevant;combinatorial;Combined Modality Therapy;Computer software;Cryopreservation;Cytometry;Development;digital;Ensure;established cell line;Fine needle aspiration biopsy;Fluorescence;Generations;Health Insurance Portability and Accountability Act;high throughput analysis;High-Throughput Nucleotide Sequencing;histological image;Histology;Human;Human Resources;Immune;Immune checkpoint inhibitor;Immunofluorescence Immunologic;Immunohistochemistry;Immunotherapy;improved;In Situ;inhibitor;Label;Laboratories;laser capture microdissection;Location;MEKs;Melanoma;Melanoma Cell;Metastatic Melanoma;Minority;Molecular;Online Systems;Paraffin Embedding;participant enrollment;Pathologic;Pathology;Patients;Performance;Phenotype;Preparation;prevent;Procedures;Process;prospective;Quality Control;rational design;Reagent;repository;Research;Research Personnel;Resistance;response;Sampling;Scanning;Services;single cell analysis;single-cell RNA sequencing;Slide;Stains;Standardization;success;Suspensions;System;T cell receptor repertoire sequencing;targeted treatment;Techniques;Technology;therapeutic evaluation;Tissue Embedding;Tissues;treatment response;tumor;tumor microenvironment;Validation;Work

PROJECT_TITLE: Core B:  Biospecimen Repository and Processing Core


ADMINISTERING_IC: HS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HOUSTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE Disease Modifying Agents (DMAs) are not effective in older adults for preventing disability and disease progression associated with aging. Therefore, the goal of this research is to evaluate deprescribing and the associated effectiveness and safety outcomes in older adults with MS. This will be the first national study to provide valuable real-world evidence regarding DMA deprescribing and the associated outcomes with significant clinical and policy implications for improving prescribing practices and quality of care in older adults with MS.

PI_NAMEs: APARASU, RAJENDER R (contact)

PROGRAM_OFFICER_NAME: SIMPSON, MATTHEW

PROJECT_TITLE: Deprescribing of Disease Modifying Agents in Older Adults with Multiple Sclerosis

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Skin Cancer

PHR: CORE C PROJECT NARRATIVE Patient-derived Xenograft (PDX) and Syngeneic Mouse Melanoma Core The study of therapeutic resistance in melanoma requires experimental models which faithfully recapitulate the complexity and heterogeneity of the disease. This proposed PDX and murine melanoma core will provide the three Projects in this application and the melanoma scientific community with a large-scale library of Patient- derived Xenograft (PDX) and murine melanoma models encompassing the genomic diversity of human melanomas. Through next generation omic profiling of these models, investigators will be able to discover or validate novel strategies to overcome resistance in the best possible melanoma model.

PI_NAMEs: MORICEAU, GATIEN P (contact)

PROJECT_TERMS: Address;biobank;Biological;Biopsy;Biopsy Specimen;Cancer cell line;Cell Line;Cells;Characteristics;Clinical;Collaborations;Collection;Colorectal Cancer;Combined Modality Therapy;Communities;Cryopreservation;Cutaneous Melanoma;Development;disease heterogeneity;Ensure;Environmental Impact;epigenomics;Evolution;exome;Experimental Models;FDA approved;Freezing;Generations;Genetic Models;Genomics;Genotype;Goals;Growth;Heterogeneity;Human;Immune;immune checkpoint;Immune system;Immunity;Immunocompetent;Immunologics;Immunotherapy;In Vitro;in vivo;Libraries;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;MAP Kinase Gene;Mediating;Melanoma;Melanoma patient;Mitogen-Activated Protein Kinase Inhibitor;Modality;Modeling;Molecular;mouse model;Multiomic Data;Mus;next generation;novel strategies;Pathway interactions;patient derived xenograft model;Patients;programmed cell death protein 1;prospective;Publishing;Reporting;Reproducibility;Research Personnel;Resistance;resistance mechanism;resistance mutation;Resources;response;Role;Services;Sister;success;System;targeted treatment;Testing;The Cancer Genome Atlas;therapeutic development;Therapeutic Studies;therapy resistant;Time;Transplantation;treatment response;tumor;Tumor Biology;tumor heterogeneity;tumor-immune system interactions

PROJECT_TITLE: Core C:  Patient Derived Xenograft (PDX)/ Syngeneic Mouse Core


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Standard and non-standard analogs of insulin and glucagon will be designed, synthesized and characterized (in cells, rats and dogs) in an effort to enhance the efficacy and safety of novel delivery devices and closed- loop systems for the treatment of T1D. Non-standard insulin modifications will be sought that, for the first time, enhance in vivo potency without increased mitogenicity, which may decrease per-unit price and illuminate molecular determinants of bio-potency (as distinct from receptor binding). Basic scientific principles underlying protein design will be explored, including structural studies.

PI_NAMEs: CHERRINGTON, ALAN D;GEORGIADIS, MILLIE M;ISMAIL-BEIGI, FARAMARZ ;WEISS, MICHAEL AARON (contact)

PROJECT_TERMS: acyl group;Adolescent;age group;Albumins;Algorithms;American;Amino Acid Substitution;Amino Acids;analog;Animals;basal insulin;Basic Science;Binding;Biotechnology;Bolus Infusion;burden of illness;Canis familiaris;Cell membrane;Cells;Chemicals;Chicago;Clinical;cost;Cryoelectron Microscopy;Data;design;Devices;diabetes management;Diabetes Mellitus;Disease;Disease Management;Dissection;Disulfides;Dose;Drug Kinetics;Elements;Endocrinology;Engineering;experience;Female;Flowers;Formulation;frontier;Glucagon;Glucagon Receptor;Glucose;Goals;Health;Hormonal;Hormones;Hypoglycemia;Impairment;in vivo;Indiana;Injections;innovation;insight;Insulin;Insulin Infusion Systems;Insulin Receptor;Insulin-Dependent Diabetes Mellitus;interdisciplinary approach;International;Investigation;Ions;Letters;Levemir;male;manufacture;Measures;Mediating;medical schools;Methods;Microfluidics;miniaturize;Modification;Mole the mammal;Molecular;Molecular Conformation;monomer;Mutagenesis;nano;next generation;NMR Spectroscopy;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Patients;pharmacologic;Play;Postage Stamps;Predisposition;Price;programs;Property;Protein Chemistry;Protein Engineering;protein function;Proteins;Pump;quantum;Rattus;receptor binding;Research Project Grants;Research Scientist Award;Resistance;Resolution;Rest;Role;Safety;Selenocysteine;solid state nuclear magnetic resonance;Specificity;Streptozocin;structural biology;Structure;Structure-Activity Relationship;Sulfur;System;Technology;Therapeutic;Time;translational potential;Translational Research;Universities;unnatural amino acids;Vision;Zinc

PROJECT_TITLE: Non-Standard Protein Design in Molecular Endocrinology: Insulin and Glucagon

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Biotechnology;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative My laboratory is pursuing fundamental questions about salivary gland development, maintenance and repair: (1) How do salivary stem cells enable organ renewal? (2) How do nerves control organ homeostasis and regeneration? (3) How does aging impact salivary stem cells? And finally, (4) How is salivary gland architecture created? We explore these questions with the ultimate goal of generating restorative therapies for restoring salivary function and improving quality of life.

PI_NAMEs: KNOX, SARAH MONICA (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Affect;Aging;Architecture;Autoimmunity;Automobile Driving;Biochemical;Biological Assay;Body System;Cells;cholinergic;Chronic Disease;craniofacial;craniofacial tissue;Development;Disease;endogenous stem cells;gland development;Goals;Homeostasis;human tissue;Image;improved;Laboratories;Maintenance;Malignant Neoplasms;Molecular;Mus;Natural regeneration;Nerve;novel;Organ;organ regeneration;organ repair;Outcome;progenitor;programs;Quality of life;regenerative approach;Regulation;repaired;Role;Salivary;Salivary Glands;Stem Cell Development;stem cell therapy;stem cells;symptom treatment

PROJECT_TITLE: Defining mechanisms driving salivary gland regeneration


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hematology;Pain Research;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: Our goal is to improve quality and duration of life for people living with sickle cell disease (SCD) in Sub-Saharan Africa by joining the Sickle Pan-African Research Consortium Collaborative (SPARCO). We will enroll 4,000 people living with SCD from our center, the Sickle Cell Disease Research and Treatment Center (CRLD) in Bamako, Mali in a longitudinal cohort study. We plan to strengthen existing standards of care at CRLD for both preventive and acute SCD. In conjunction with SPARCO, we will perform observational and implementation research studies and seek to coordinate regionally feasible standards of care across Sub-Saharan Africa.

PI_NAMEs: GUINDO, ALDIOUMA  (contact)

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Acceleration;Acute;acute care;Address;Africa;Africa South of the Sahara;African;Age;aged;Anti-malarials;Antibiotics;Bacterial Infections;cardiovascular disorder risk;Caring;Cephalic;Chemoprophylaxis;Child;Clinical;clinical care;Clinical Data;clinical practice;Clinical Protocols;cohort;Communicable Diseases;Communities;cost effectiveness;Counseling;Data;Data Collection;Development;Diagnosis;Diagnostic Services;Education;Educational Intervention;Electronics;Enrollment;Ensure;Etiology;Evidence based intervention;Face;Family;Fetal Hemoglobin;Fever;Fingers;Future;Geography;Goals;Health;Health Personnel;Heart Diseases;Hematological Disease;Heterozygote;high risk;hydroxyurea;implementation determinants;implementation evaluation;implementation outcomes;implementation research;improved;Incidence;Individual;Infection;infection risk;Inherited;Institutional Review Boards;instrument;Kidney Diseases;Life;Lifting;Longitudinal cohort;Longitudinal cohort study;Malaria;Mali;Measures;meetings;Methods;Molecular Diagnosis;National Heart, Lung, and Blood Institute;Neonatal Screening;Observation in research;Observational Study;Ontology;Organ;Outcome;Outpatients;Pain;Pain management;participant enrollment;patient population;Patients;Persons;Population;Predisposition;Preventive;Preventive care;Process;Prophylactic treatment;Protocols documentation;Proverb;quality assurance;Quality of Care;Registries;Research;research study;response;risk mitigation;Risk Reduction;Safety;sample collection;screening;screening program;Services;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Site;Standardization;standardized care;Stroke;stroke risk;Teleconferences;Training;Transfusion;treatment center;Vaccination;Vaccines;Vascular Diseases;Visit

PROJECT_TITLE: Improving Sickle Cell Disease Care in Mali through Engagement with a Pan-African Sickle Cell Disease Network.


NIH_SPENDING_CATS: Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative This project will 1) train clinical neuroscientists, neuro-engineers and computational neuroscientists to perform research that produces breakthroughs in the recovery and restoration of function for patients with acute brain injury from stroke and trauma and, 2) prepare these researchers to become independent investigators who devote their careers to producing those breakthroughs and translating them to benefit individuals who have suffered acute central nervous system injuries from atraumatic and traumatic causes.

PI_NAMEs: HOCHBERG, LEIGH R (contact);ROSAND, JONATHAN

PROJECT_TERMS: Health;programs;Recovery;restoration

PROJECT_TITLE: Program in Recovery and Restoration of CNS Health and Function


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The primary aim of the proposed randomized parallel-group design clinical trial in 94 patients over 65 years old with heart failure with reduced ejection fraction (HFrEF) is to determine if exercise rehabilitation initiated with 4 weeks of a new intervention PRIME (focused on peripheral tissue beds without a significant cardiovascular workload) prior to 8 weeks of guideline recommended exercise (COMBO-aerobic and resistance training) is more beneficial that currently recommended 12 weeks of COMBO training. Our primary outcome measures are group changes in VO2peak (a critical predictor of death and hospitalization) during maximal cycle ergometry graded exercise test, with secondary clinical aims of strength (maximal voluntary contractions) and function (senior fitness test) will also be examined. We will examine the relative contributions of central (cardiac) and peripheral (skeletal muscle) markers to fitness and function and preliminarily explore if they endure at a 6-month follow-up timepoint.

PI_NAMEs: ALLEN, JASON DAVID (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: actigraphy;Activities of Daily Living;Address;Adherence;Adult;Aerobic;Aerobic Exercise;Age;Aging;American;Anaerobic Threshold;Aorta;Beds;Biogenesis;Biopsy;Blood;Blood flow;Blood Pressure;bone;Bone Density;Bone Mineral Contents;Capillarity;Cardiac;Cardiovascular system;Cessation of life;Classification;Clinical;Clinical Trials Design;cohort;comorbidity;Control Groups;Data;Death Rate;design;Diagnosis;Direct Costs;Elderly;Ergometry;Exercise;exercise capacity;exercise intolerance;exercise prescription;exercise program;exercise rehabilitation;Exercise Test;exercise training;Exhibits;experience;Facilities and Administrative Costs;Fatigue;Fiber;fitness;fitness test;follow-up;Functional disorder;Functional impairment;functional independence;Goals;Guidelines;Health;Health Professional;Heart failure;heart failure with reduced ejection fraction;hemodynamics;High Prevalence;Hospitalization;human old age (65+);Hybrids;Impairment;improved;indexing;Individual;insight;interest;Intervention;Mediator;men;Mitochondria;Modality;Muscle;muscle metabolism;Muscle satellite cell;muscle strength;Muscular Atrophy;Musculoskeletal;myogenesis;Near-Infrared Spectroscopy;novel;older adult;older patient;Older Population;Outcome;Outcome Measure;Participant;Patients;Perfusion;Peripheral;Persons;Physical activity;Physical Fitness;Physical Function;pilot test;Population;primary outcome;Procedures;Prognosis;prognosis biomarker;programs;Publications;Quality of life;Questionnaires;Randomized;Randomized, Controlled Trials;Recommendation;reduced muscle mass;Resistance;resistance exercise;Rest;Risk;sarcopenia;Serum Markers;Severities;Shortness of Breath;Skeletal Muscle;Stimulus;Stress;Therapeutic;Tissues;tonometry;Training;Treatment Cost;trial enrollment;Walking;Woman;Workload

PROJECT_TITLE: PRIME HRrEF:  Novel Exercise for Older Patients with Heart Failure with Reduced Ejection Fraction

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative: In response to excess calories, white adipose tissue expands by both generating more adipocytes via de novo adipogenesis and by enlarging existing adipocytes. The relative balance between these two modes of expansion has significant consequences to metabolic health. We propose that the primary cilium, a small antenna-like signaling organelle, of pre-adipocytes regulates how white adipose tissue expands, and that ciliary dysfunction in this context contributes to adipose tissue dysfunction and pathogenesis.

PI_NAMEs: HILGENDORF, KEREN  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Ablation;Adipocytes;Adipose tissue;Adult;Affect;Alstrom syndrome;Architecture;Bardet-Biedl Syndrome;Biological;Body mass index;Calories;Cells;Chromatin;chromatin remodeling;Cilia;ciliopathy;comorbidity;Cyclic AMP;Data;Defect;Development;Diabetes Mellitus;DNA Sequence Alteration;Docosahexaenoic Acids;Equilibrium;experimental study;Fatty acid glycerol esters;Female;Functional disorder;Genes;Genetic;Genetic Transcription;glucose metabolism;Goals;Health;Human;Human Genetics;Hyperplasia;Hypertrophy;Impairment;in vivo;Inflammation;innovation;Insulin Resistance;Lead;Ligands;Link;lipid biosynthesis;lipid metabolism;male;Metabolic;Metabolic syndrome;Molecular;Monounsaturated Fatty Acids;Morphology;mouse model;Mus;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Nutrient;Obese Mice;Obesity;Omega-3 Fatty Acids;Organelles;Overweight;pandemic disease;Pathogenesis;Pathogenicity;Patients;Polyunsaturated Fatty Acids;Proteins;Public Health;Publishing;receptor;Research;response;Signal Pathway;Signal Transduction;Techniques;Thinness;Tissue Differentiation;Tissue Expansion;Tissues;tool;trafficking

PROJECT_TITLE: Ciliary signaling mechanisms regulating white adipose tissue expansion

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The National Center for Quantitative Biology of Complex Systems develops novel technologies that accelerate the pace and depth of protein, lipid, and metabolite analysis. These molecules, and their interactions, regulate the complex cellular processes underlying many devastating diseases. Specifically, the technologies developed in this Resource are being used to advance our understanding of many human conditions including diabetes, Alzheimer’s disease, cancer, and heart disease, among others.

PI_NAMEs: COON, JOSHUA J (contact)

PROJECT_TERMS: Acceleration;Achievement;Alzheimer's Disease;Automobile Driving;Biological;biological systems;Biology;Biomedical Research;Biomedical Technology;Biotechnology;Calibration;Cell Physiology;Chromatography;Collaborations;Communities;community engagement;Complex;Computer software;Data;design;Development;Diabetes Mellitus;Disease;Ensure;Evolution;Gene Expression;Genes;Genome;Genomics;Glean;Goals;Heart Diseases;holistic approach;Human;innovation;insight;interest;Internet;Knowledge;Laboratories;Large-Scale Sequencing;Legal patent;lipidome;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;material transfer agreement;Measurement;Metabolism;metabolome;Mission;Molecular;multiple omics;new technology;novel;Nucleic Acids;Pathogenesis;Physiology;Post-Translational Protein Processing;Process;Proteins;Proteome;Proxy;Publications;Regulation;Reporter;Research Personnel;Research Project Grants;Resources;RNA;Role;Scientist;Shoulder;Speed;success;System;Technology;Technology Transfer;Testing;tool;Training;Training Programs;Transcript;transcriptome;Visit;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(40)R]


PROJECT_TITLE: National Center for Quantitative Biology of Complex Systems

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J]


PROJECT_TERMS: Adherence;Amides;Amino Acids;Anions;Automobile Driving;Biology;Biomedical Research;Cations;Cells;Charge;Chromatography;Complex;Creativeness;density;design;Development;Dissociation;Electron Transport;Electrons;experimental study;Fiber Optics;flexibility;Free Radicals;Frequencies;Funding;Future;Generations;Glycopeptides;Glycosaminoglycans;glycosylation;Hybrids;improved;innovation;ion source;ionization;Ions;irradiation;Knowledge;Maps;mass analyzer;Mass Spectrum Analysis;meter;Methods;Modernization;multiple omics;Names;new technology;Nucleic Acids;Pathway interactions;Peptides;Photons;Post-Translational Protein Processing;Process;protein aminoacid sequence;Proteome;Proteomics;protonation;Reaction;reaction rate;Reagent;Recording of previous events;Research Personnel;Resources;Risk;Scanning;small molecule;Speed;success;System;tandem mass spectrometry;Technology;Time;user-friendly;Variant;Vendor;Vertebral column


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE For patients with advanced cancer, pain is a common and disabling symptom for which opioids remain a mainstay of treatment. The current epidemic of opioid misuse and addiction has led to widespread changes in opioid-related policies, and the impacts of these policies on patients with advanced cancer near end of life are not well understood. This project will inform how state-level opioid policies can be structured to ensure safe and equitable opioid access for the roughly 600,000 adults who die from cancer annually in the United States.

PI_NAMEs: SABIK, LINDSAY MARIE (contact);SCHENKER, YAEL

PROGRAM_OFFICER_NAME: ZHANG, XINZHI

PROJECT_TITLE: Policies to Inform Safe and Equitable Opioid Access for Patients with Advanced Cancer Near End of Life

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Dementia leads to tremendous suffering among patients and families as well as huge societal costs. This program project is grounded in the linkage of medical, social, and health system contexts of dementia with inter-related research projects/cores that together will lead to improved care for this vulnerable population.

PI_NAMEs: COVINSKY, KENNETH E.;MORRISON, R. SEAN (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: Address;Adult;Affect;Age;Aging;Algorithms;Alzheimer's disease related dementia;Caregivers;Caring;Cessation of life;Chronic;Chronic Disease;Clinical;clinical care;Code;Collaborations;Communities;community based care;community based service;Complex;cost;Coupled;Data;Data Collection;data dictionary;data resource;Data Set;Dementia;dementia care;Disease;Drug Prescriptions;Economics;end of life;Enrollment;Event;Face;Family;family burden;Family health status;Financial Hardship;follow-up;Funding;Future;Geography;Goals;Grant;Health;Health and Retirement Study;health data;health service use;Health Services Research;Health system;Healthcare;Healthcare Systems;Home;Hospice Care;hospice environment;improved;improved outcome;Intervention;Lead;Medical;Methodology;Modeling;Nursing Homes;older adult;Outcome;Participant;Patients;Persons;Pharmaceutical Preparations;Play;Policies;Policy Maker;population based;Population Heterogeneity;Population Study;Productivity;programs;psychologic;psychosocial;Quality of life;Research;Research Activity;Research Personnel;Research Project Grants;Resources;retention rate;Sample Size;Sampling;Science;social;social health determinants;social stigma;societal costs;socioeconomics;System;trend;Vulnerable Populations

PROJECT_TITLE: DEploying High ValuE LOngitudinal Population-Based dAta in Dementia Research (DEVELOP AD Research)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Palliative Care

PI_NAMEs: MORRISON, R. SEAN (contact)

PROJECT_TERMS: Academy;Acceleration;Address;Aging;Agreement;Award;Budgets;California;career development;Caregivers;Caring;Clinical;clinical practice;Code;Collaborations;Communities;community based care;Complex;cost efficient;Data;data dictionary;data management;data resource;Data Security;Data Set;Data Sources;Dementia;Disease;Drug Prescriptions;Elderly;Ensure;epidemiologic data;Event;evidence base;experience;Family;Feedback;Fostering;Funding;Geriatrics;Gerontology;Goals;Health;health care quality;health data;Health Policy;Health system;Healthcare;Home;hospice environment;Hour;human subject;improved;Infrastructure;innovation;Institution;Knowledge;Leadership;Learning;Manuals;Medical;medical schools;Medicine;Mentors;Methodology;Modeling;Monitor;next generation;older adult;Outcome;Palliative Care;patient population;Patients;Personal Satisfaction;Persons;Policies;Population;population based;Population Research;Preparation;programs;Publications;Quality of life;remediation;Reporting;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Support;Resource Sharing;Resources;Retirement;Role;San Francisco;Scientist;social;Social Environment;Training Activity;Translating;Translations;trend;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


PI_NAMEs: LI, LINGJUN  (contact)

PROJECT_TERMS: Alanine;Amines;Amino Acids;Biocompatible Materials;Biological;Biology;Biomedical Technology;Cells;chemical reaction;Chemicals;Collection;commercialization;Complex;Data;Data Analyses;Defect;design;Dissociation;Electron Transport;Emerging Technologies;experimental study;Gases;Goals;human tissue;improved;instrument;Ions;Isotopes;Label;Leucine;Light;Liquid substance;Mass Spectrum Analysis;Measures;Metabolic;Methods;Mission;Modernization;Mus;Noise;novel;novel strategies;Ornithine;parallel processing;Peptides;Phase;photoactivation;Post-Translational Protein Processing;Preparation;prevent;Production;Proline;Proteins;Proteome;Reaction;Reporter;Resources;Sampling;scaffold;Signal Transduction;Stable Isotope Labeling;Structure;success;synergism;System;Systems Biology;tandem mass spectrometry;Techniques;Technology;Testing;Time;translational medicine


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The goal of this research program is to understand metabolic stress responses of adipose tissue. The focus of our analysis is on the stress responsive cJun NH2-terminal kinase (JNK) signaling pathway. We propose to combine physiological analysis together with an investigation of JNK isoforms to define molecular mechanisms that mediate adipose tissue stress responses. The knowledge obtained may represent a basis for the design of novel therapeutic strategies for the treatment of metabolic syndrome and type 2 diabetes.

PI_NAMEs: DAVIS, ROGER J. (contact)

PROGRAM_OFFICER_NAME: BASU, RAJATAVA

PROJECT_TERMS: Achievement;Address;Adipocytes;adipokines;Adipose tissue;Alternative Splicing;Amino Acid Sequence;Amino Acids;B-Lymphocytes;Binding Sites;biological adaptation to stress;design;Development;Exhibits;Exons;feeding;FGF21 gene;fibroblast growth factor 21;Functional disorder;Genes;Goals;Health;High Fat Diet;Human;Hyperglycemia;IL6 gene;Inflammation;insight;Insulin Resistance;Investigation;Knowledge;loss of function;MAPK8 gene;MAPK9 gene;Mediating;Messenger RNA;Metabolic stress;Metabolic syndrome;Molecular;Mus;N-terminal;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Obesity;obesity development;Phosphotransferases;Physiological;Physiology;preference;prevent;programs;Protein Isoforms;Protein Kinase;Research;response;Role;Signal Pathway;Signal Transduction;Stress;Substrate Specificity;Testing;Text;Therapeutic Intervention;Transcript;treatment strategy

PROJECT_TITLE: Adipose Tissue Metabolic Stress Responses


PI_NAMEs: KELLEY, AMY STEVES (contact)

PROJECT_TERMS: Aging;Algorithms;analytical method;analytical tool;California;Caregivers;Cataloging;Cessation of life;clinical care;clinically relevant;Code;Collaborations;Complex;cost;Data;data cleaning;data management;Data Set;Database Management Systems;Dementia;dementia care;Diagnosis;Disease;Documentation;Economics;Elderly;Ensure;Epidemiologist;Event;experience;Family;Family health status;follow-up;Funding;Goals;Health;Health and Retirement Study;health service use;Health Services;Health system;Home;hospice utilization;Human Resources;Individual;Infrastructure;Knowledge;Libraries;Library Materials;Link;longitudinal course;Medical;medical schools;Medicare;Medicare/Medicaid;Methods;Modeling;novel;Observational Study;Online Systems;Palliative Care;Patients;Persons;Pharmaceutical Preparations;Policies;Policy Maker;population based;Population Study;Process;programs;Research;Research Personnel;Research Project Grants;Research Support;Resources;Sample Size;San Francisco;Scientist;skills;social;Statistical Methods;Surveys;synergism;Techniques;Time;Time Series Analysis;trend;United States Centers for Medicare and Medicaid Services;Universities;Weight;Work

PROJECT_TITLE: Quantitative Analytics and Data Management


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Immunization;Orphan Drug;Osteogenesis Imperfecta;Pediatric;Physical Injury - Accidents and Adverse Effects;Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine

ORG_CITY: ANN ARBOR

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative Osteogenesis Imperfecta (OI) is a genetic low bone density disorder characterized by increased bone fracture, often from little or no apparent trauma. Current treatments are based on anti-resorptives that prevent fractures, yet may interfere with normal jaw bone healing. This study will develop an innovative OI treatment strategy by increasing bone formation to benefit implant osseointegration (bone healing) with anabolic Sclerostin antibody and to diagnose this SclAb-induced bone density with minimally invasive and sensitive bone-remodeling related miRNA biomarkers.

PI_NAMEs: SUNG HSIEH, HSIAO HSIN  (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Advisory Committees;Affect;Algorithms;antagonist;Antibodies;Antibody Therapy;Biological Markers;biomarker identification;Biomechanics;bisphosphonate;Body Fluids;bone;Bone Density;bone healing;bone mass;bone metabolism;Bone Regeneration;Bone remodeling;Bone Tissue;career;Clinical;clinical application;Committee Members;craniofacial;Dental;Dental Implants;Diagnosis;differential expression;Disease;Doctor of Philosophy;Dose;Dysplasia;Encapsulated;Ensure;exosome;experimental study;Fracture;Genetic;Goals;healing;Homeostasis;Immunohistochemistry;Implant;Implantation procedure;improved;innovation;Intervention;Jaw;Knowledge;Learning;long bone;Maxilla;Mechanics;Mentors;Michigan;microRNA biomarkers;MicroRNAs;minimally invasive;Modeling;Molecular;Monitor;Morphology;mouse model;Mus;novel strategies;Operative Surgical Procedures;oral surgery specialty;Oral Surgical Procedures;orofacial;Orthopedics;osseointegrated implant;Osseointegration;Osteogenesis;Osteogenesis Imperfecta;Pathway interactions;Patients;personalized medicine;Pharmaceutical Preparations;Phase;Phenotype;Play;Positioning Attribute;prevent;Process;professor;Property;Quality of life;Regenerative Medicine;Regimen;Regulation;Research;Research Project Grants;response;Sampling;Schedule;School Dentistry;Scientist;Serum;Severity of illness;Short-Term Course;skeletal;skills;Specificity;support tools;Surgeon;surgery outcome;Techniques;Testing;Time;tool;Training;Trauma;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;Universities;Wild Type Mouse;Work

PROJECT_TITLE: Biomarking the Sclerostin Antibody Effects on Osseointegration in an Osteogenesis Imperfecta Model

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Patient Safety;Social Determinants of Health

PROJECT_TERMS: Address;Admission activity;Advanced Malignant Neoplasm;African American population;Aging;care costs;caregiver strain;Caregivers;caregiving;Caring;Cessation of life;Characteristics;Chronic;Cohort Studies;Communication;Consumption;cost;daily functioning;Data;Dementia;Disparity;Ensure;experience;Face;Family;Functional impairment;Goals;Guidelines;Health;Health and Retirement Study;Health Care Costs;Health Policy;Health system;Healthcare;Heart failure;high risk;high school degree;Home;Hospital Mortality;Hospitalization;Hospitals;Hour;improved;Individual;Intervention;Interview;Knowledge;Latino Population;Length of Stay;Life;Longitudinal Surveys;Medical;Medicare;Medicare claim;meetings;Methods;mortality risk;novel;Nursing Homes;older adult;Outcome;Pain;Palliative Care;patient oriented;Patients;Persons;Population;population based;Population Heterogeneity;preference;Prevalence;Probability;prognostic;programs;prospective;Public Health;Quality of Care;Quality of life;racial disparity;Research;Risk;Sampling;Social Policies;social vulnerability;Societies;socioeconomic disparity;Subgroup;Symptoms;System;Time;trend;Uncertainty;Underserved Population;Unmarried;Vulnerable Populations;Work

PROJECT_TITLE: Double Danger: Additive Effects of Dementia and Additional Serious Illness on Patient, Caregiver, and Health System Outcomes


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: RICE UNIVERSITY

PHR: PROJECT NARRATIVE Appropriately coordinated gene expression is involved in almost every process underlying human health and disease. Our studies will uncover new mechanistic insights into how human genes are controlled and will enable biomedical researchers to reshape gene expression easily and precisely within living cells. Since gene expression is fundamentally important, this new knowledge and technical ability can spur improved treatments for several human diseases and can result in new ways to sculpt clinically useful cellular behaviors.

PI_NAMEs: HILTON, ISAAC  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;cell behavior;cell type;Cells;Chromatin;chromatin modification;Chromatin Remodeling Factor;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;design;Disease;DNA Methylation;epigenome editing;epigenomics;Equilibrium;Gene Expression;Gene Expression Regulation;Genes;genomic locus;Goals;Health;Histones;Human;human disease;Human Genome;improved;insight;interdisciplinary approach;Knowledge;Modification;novel therapeutics;nuclease;Post-Translational Protein Processing;Process;protein complex;Proteins;Proteomics;Regulatory Element;Research Personnel;Resolution;Shapes;Site;spatiotemporal;System;Technology;Therapeutic;tool;transcription factor

PROJECT_TITLE: Site-specific control of human gene regulation for therapeutically applicable mechanistic insights

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

PROJECT_TERMS: Address;adduct;Biological;Biological Assay;Biology;Biomedical Technology;Cells;Chromatography;Complex;Complex Mixtures;computerized data processing;Consumption;Coupling;data acquisition;Data Analyses;dimer;Disease;equipment acquisition;Exclusion;Expeditions;Foundations;Fracture;Gases;Genes;Goals;Heterogeneity;high throughput technology;Hour;Human;human genome sequencing;Hybrids;improved;innovation;innovative technologies;Instruction;instrument;ion mobility;Isomerism;Laboratories;lipidome;lipidomics;Lipids;liquid chromatography mass spectrometry;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Medicine;metabolome;metabolomics;Methodology;Methods;Mission;Modernization;Molecular;Monitor;multiple omics;nano-liquid chromatography;National Center for Research Resources;Noise;Nucleic Acids;Organism;Peptides;Performance;Persons;Phase;Preparation;prevent;Protein Analysis;Proteins;Proteome;Proteomics;Reproducibility;Resolution;Resources;Running;Sampling;Signal Transduction;Source;Structure;success;System;tandem mass spectrometry;Techniques;Technology;Time;tool;Transcript;Translating;ultra high pressure;Work;Yeasts


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PI_NAMEs: GREENBAUM, CARLA J (contact)

PROGRAM_OFFICER_NAME: BROADNEY, MIRANDA MARGUERITE

PROJECT_TERMS: Antibodies;Area;Australia;Autoantibodies;Canada;Clinical;clinical center;clinical diagnosis;Clinical Trials;Communication;Conduct Clinical Trials;Data;Development;Diabetes Mellitus;Disease;Disease Progression;Enrollment;Finland;Germany;Goals;Grant;Individual;Information Dissemination;innovation;insulin dependent diabetes mellitus onset;Insulin-Dependent Diabetes Mellitus;International;Italy;member;Mission;Monitor;Natural History;Participant;Phase I Clinical Trials;prevent;Prevention;Process;recruit;Research Personnel;Risk;screening;Site;success;Sweden;Thinking;Time

PROJECT_TITLE: Type 1 Diabetes TrialNet Clinical Network Hub


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Patient Safety

PROJECT_TERMS: Admission activity;Adult Children;advanced dementia;adverse outcome;Alzheimer's disease related dementia;Antibiotics;Attention;care systems;Caregivers;Caring;Cessation of life;Clinical;cognitive function;Communities;comorbidity;cost;Data;Decision Making;Dementia;design;Disease;Emergency department visit;Emotional;end of life;Event;experience;Family;functional decline;Health;Health and Retirement Study;Health Care Costs;health care service utilization;Health system;Healthcare Systems;Heterogeneity;high risk;Hip Fractures;Home;hospital readmission;Hospitalization;Hour;improved;Incidence;Intervention;Knowledge;Link;Measures;Medical;Medicare;Medicare claim;Modeling;Nursing Homes;Occupational activity of managing finances;older adult;Operative Surgical Procedures;Outcome;Patients;Persons;Physical Function;Physiological;Pneumonia;Policies;Policy Maker;Population;population based;Prevalence;prevent;Prognosis;prognostic;repaired;Research;Self Care;Serious Adverse Event;social;sociodemographics;Spouses;System;therapy design;Traumatic injury;Uncertainty;Work

PROJECT_TITLE: The Impact of Disruptive Events Among Community-Dwelling Persons with Dementia