ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Primary Health Care;Schizophrenia;Serious Mental Illness;Substance Misuse

PHR: The Chronic Disease Self-Management program (CDSMP) is shown to improve disease self-management skills and behaviors in a range of clinical populations. I propose to adapt the CDSMP for primary care patients with opioid use disorder (OUD) and serious mental illness (SMI), assess its feasibility and acceptability in a small randomized trial, qualitatively evaluate its implementation in a primary care environment using the Rapid Assessment Procedure Informed Clinical Ethnography procedure. I will also engage in career development and training activities that will enhance my expertise in adapting, implementing, and testing of a CDSMP for persons with OUD and SMI.

PI_NAMEs: SIANTZ, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adoption;Adult;Area;Behavior;Buprenorphine;career;career development;Caring;Chronic Disease;Clinic;Clinical;Clinical Investigator;Clinical Trials;Clinical Trials Design;community advisory board;community intervention;Complex;contextual factors;design;Disease;Disease Management;Dissemination and Implementation;Doctor of Philosophy;Education;education resources;Educational Intervention;effectiveness study;Environment;ethnographic method;Ethnography;evidence base;Evidence based treatment;experience;Feasibility Studies;feasibility testing;Formulation;Foundations;Future;gaps in access;gender diversity;gender equity;Goals;Health;Health education;health related quality of life;Helping to End Addiction Long-term;high risk;Hybrids;implementation barriers;implementation context;implementation evaluation;implementation facilitators;implementation intervention;implementation process;implementation research;implementation science;Improve Access;improved;innovation;Intervention;Interview;Leadership;Mental Health Associations;Mental Health Services;Mentored Research Scientist Development Award;Mentors;Methods;mortality;Naltrexone;novel;opioid epidemic;opioid overdose;opioid use disorder;Outcome;Participant;Patient Education;patient population;Patients;peer;Persons;Pharmaceutical Preparations;physical conditioning;Pilot Projects;Population;Positioning Attribute;Primary Care;primary care clinic;primary care patient;primary care provider;primary care services;primary care setting;Procedures;Process;programs;Provider;Qualitative Evaluations;Quality of Care;Randomized;randomized trial;Reporting;Research;Research Personnel;Resources;satisfaction;Science;Scientist;Self Management;self-management program;Services;severe mental illness;Site;skill acquisition;skills;social health determinants;social vulnerability;Social Workers;Statistical Data Interpretation;Symptoms;systematic review;Testing;Time;tool;Training;Training Activity;treatment as usual;United States National Institutes of Health

PROJECT_TITLE: Adapting and Implementing a Chronic Disease Self-Management Program for Primary Care Patients with Opioid Use Disorder and Serious Mental Illness

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: HANOVER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Primary care plays an essential role in the prevention, treatment and ongoing management of the many chronic conditions that contribute not only to premature death and disability overall, but also to the pervasive health disparities observed among older adults in the United States. This project will use a unique national data set spanning the years 2015 through 2024 to: (1) describe the magnitude of inequities in primary care access and quality for Medicare beneficiaries; (2) understand how these changed during this period; and (3) identify high-leverage interventions that can be taken by policy makers, health system leaders, and primary care practices to improve care and reduce health disparities among older adults.

PI_NAMEs: FISHER, ELLIOTT S;SCHIFFERDECKER, KAREN E. (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Academy;Address;Adoption;Age;Alzheimer's disease related dementia;beneficiary;burden of chronic illness;care outcomes;Caring;Case Study;Cessation of life;Chronic;cohort;Communities;contextual factors;County;COVID-19;COVID-19 pandemic;Cross-Sectional Studies;Data;data resource;Data Set;Diagnosis;disability;Disease Progression;Disparity;disparity reduction;Economics;Ensure;evidence base;falls;Fee-for-Service Plans;Foundations;Funding;Goals;Health;health determinants;health disparity;Health Services Accessibility;Health system;Healthcare;Healthcare Systems;Hospitalization;improve minority health;improved;Incidence;Inequity;informant;insight;Intervention;Interview;Investigation;Life Expectancy;Link;Low income;Measures;Medicaid;Medicare;Medicare claim;Medicine;Methods;Minority;Minority Groups;minority health disparity;modifiable risk;mortality;Names;Neighborhood Health Center;older adult;Outcome;Ownership;Physicians;Play;Policies;Policy Maker;Population;practice factors;premature;prevent;Prevention;Primary Care;Primary Care Physician;primary care practice;primary care provider;Process;Qualitative Research;Quality of Care;Recommendation;Reduce health disparities;Reporting;Research Project Grants;residential segregation;Resources;Respondent;Risk;Role;Rural;rural residence;safety net;Sampling;Site;social;Surveys;System;Testing;Travel;trend;United States;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Update;Wood material;Work

PROJECT_TITLE: Understanding and Addressing Disparities in Primary Care: A National Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-W(02)M]


ADMINISTERING_IC: CA

ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Health Services;Palliative Care;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE The goal of this program is to increase the number of cancer researchers conducting comparative effectiveness research (CER) at the national level. The proposed intensive curriculum will provide program participants with a strong foundation in CER, and the knowledge and skills to design and conduct CER studies including ‘real-world’ observational studies, pragmatic clinical trials and knowledge synthesis. The program will benefit public health by advancing the use of comparative evidence, which can inform cancer patients, caregivers and providers of the benefits and harms of alternative healthcare options and provide value-based care that can extend the length and quality of life of cancer patients.

PI_NAMEs: SUAREZ-ALMAZOR, MARIA E (contact)

PROGRAM_OFFICER_NAME: ELJANNE, MARIAM

PROJECT_TERMS: Address;Advisory Committees;Alternative Health;anti-cancer research;Area;arm;cancer care;Cancer Center;Cancer Patient;cancer therapy;Career Choice;Caregivers;Caring;Clinical;Clinical Trials;comorbidity;comparative;comparative effectiveness;Comparative Effectiveness Research;Controlled Environment;Country;Data;Data Analyses;Data Set;Decision Analysis;Decision Making;Decision Modeling;design;Development;Diagnosis;Discipline of Nursing;Education;Educational Activities;Educational Curriculum;Educational workshop;effectiveness evaluation;Effectiveness of Interventions;effectiveness study;end of life care;Enrollment;Ensure;evidence based guidelines;Exclusion;expectation;Faculty;Fellowship Program;Foundations;Goals;Health;health care delivery;Health Sciences;Healthcare;Individual;innovation;Institution;interest;Intervention;Knowledge;knowledge base;knowledge translation;lectures;Length;Link;Malignant Neoplasms;Medical;Medicare claim;Meta-Analysis;Methodology;Methods;Mission;Modeling;National Cancer Institute;new technology;Nonprofit Organizations;novel strategies;Observational Study;Oncology;online course;Outcome;Participant;patient oriented;Patient-Focused Outcomes;Patients;Pattern;Persons;Play;Policy Maker;Population;Positioning Attribute;Postdoctoral Fellow;Pragmatic clinical trial;pragmatic trial;Prevention;Probability;Process;Program Evaluation;programs;protocol development;Protocols documentation;Provider;Public Health;Quality of life;Randomized, Controlled Trials;recruit;Registries;Research;Research Methodology;Research Personnel;research study;Research Training;Role;Scientist;screening;SEER Program;Series;skills;Source;Supportive care;survivorship;systematic review;Technology;tool;Training;Training Activity;Training Programs;trial comparing;Underrepresented Minority;Work

PROJECT_TITLE: Methods Training for Comparative Effectiveness Research in Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ORG_CITY: GRAND RAPIDS

ORG_NAME: VAN ANDEL RESEARCH INSTITUTE

ORG_STATE: MI

PHR: PROJECT NARRATIVE  Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by the rapid onset of premature aging beginning in childhood. We propose to investigate whether disrupted epigenetic control contributes to some of the premature aging symptoms in HGPS. The outcome of this proposed research could potentially open avenues for new therapeutic approaches to treat progeria and shed light on the mechanisms in normal aging.

PI_NAMEs: LAIRD, PETER W (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Acceleration;age acceleration;aging related;Automobile Driving;Biological Models;bisulfite sequencing;Catalytic Domain;Cell Aging;Cell Culture Techniques;Cell division;Cell Nucleus;Cell Physiology;Cells;Childhood;Chromatin;Communities;cost effective;Cytosine;Data;design;Dioxygenases;DNA analysis;DNA biosynthesis;DNA Damage;DNA Methylation;DNA Modification Methylases;Elements;Epigenetic Process;Event;Experimental Designs;experimental study;extend lifespan;farnesylation;Fibroblasts;gain of function;Gene Expression;Genes;Genetic;Genome;Genomic Imprinting;Genomics;Heterochromatin;Human;innovation;lentivirally transduced;life span;LMNB1 gene;Methods;methylation pattern;methylome;Mitosis;Mitotic;Modeling;Monitor;Morphology;mouse genome;mouse model;Mus;Muscular Atrophy;mutant;Mutation;normal aging;novel therapeutic intervention;Nuclear;Nuclear Lamin;Nuclear Lamina;Nuclear Protein;Outcome;overexpression;oxidative damage;Patients;Pattern;Phenotype;Play;Polycomb;Population;prelamin A;Premature aging syndrome;Production;Progeria;Protein Export Pathway;Protein Isoforms;Publishing;rare genetic disorder;Recording of previous events;replication stress;Repression;Research;Resolution;RNA-Directed DNA Polymerase;Role;senescence;Smooth Muscle;Smooth Muscle Myocytes;spatiotemporal;Structure;Symptoms;Syndrome;Telomerase;Testing;Tissues;Validation;vector;whole genome;X Inactivation

PROJECT_TITLE: Accelerated DNA Methylation Alterations in Hutchinson-Gilford Progeria Syndrome

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: NARRATIVE The National Dementia Workforce Study (NDWS) will be launched by a national team of experts in clinical care of persons living with dementia, survey research, and health workforce research. The core of NDWS will be four surveys that reflect key elements of the professional dementia care workforce in the U.S.: Community Clinicians, Nursing Home Staff, Assisted Living Staff, and Home Care Staff. By pairing the surveys with additional linked data sources, the NDWS data infrastructure will allow researchers and policymakers to ask critical questions related to the care provided to the growing population of persons living with dementia in the U.S.

PI_NAMEs: MAUST, DONOVAN T (contact);SPETZ, JOANNE E.

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Accident and Emergency department;Accounting;Address;Affect;Alzheimer's disease related dementia;American;Amyloid;Area;Assisted Living Facilities;Bioethics;blood-based biomarker;care coordination;care delivery;care providers;Caregivers;Caring;Certification;Cholinesterase Inhibitors;Clinical;clinical care;college;Communities;Community Healthcare;Community Services;Complex;cost;Country;Data;Data Collection;data exchange;data infrastructure;Data Linkages;Data Set;Data Sources;Dementia;dementia care;Device or Instrument Development;Diagnostic Imaging;Discipline of Nursing;Doctor of Philosophy;Elements;Ethics;evidence base;experience;Face;Family;family caregiving;Goals;Health Personnel;Healthcare;Healthcare Systems;Home Care Agencies;Home Health Aides;Hospital Referrals;hospitalization rates;implementation science;improved;Infrastructure;insight;Intervention;Investments;Knowledge;Licensed Practical Nurse;Licensing;Link;Medical;Medical Care Costs;Medicare/Medicaid;meetings;Methods;Nurses;Nursing Homes;Occupations;older adult;Outcome;patient home care;Persons;Physicians;Policies;Policy Maker;Population;practice setting;primary care clinician;primary care practice;Provider;psychosocial;Public Health;Quality of Care;referral services;Reporting;Research;Research Methodology;Research Personnel;research study;Research Support;screening;Secure;Self Care;Shapes;skills;Surveys;Training;Variant

PROJECT_TITLE: The National Dementia Workforce Study


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative

PI_NAMEs: MAUST, DONOVAN T (contact)

PROJECT_TERMS: Alzheimer's Disease;Assisted Living Facilities;Awareness;Bioethics;Biometry;care delivery;care providers;Caregivers;Caring;Clinical;clinical care;Communication;Communities;community building;Competitive Bidding;Complex;Consultations;cooperative study;Country;Data;Data Collection;data infrastructure;Data Set;Data Sources;Decision Making;Dementia;dementia care;design;Discipline;Discipline of Nursing;Disparate;Documentation;Economics;Elements;Ensure;Ethics;Family;Funding;Goals;health care service;Health Personnel;implementation science;improved;Individual;Infrastructure;insight;Institution;Insurance Claim Review;Investments;Knowledge;Laws;Leadership;Link;Logistics;Medicine;Methodology;Methods;Mission;Nurses;Nursing Homes;organizational structure;patient home care;Persons;Pharmacological Treatment;Physicians;Policy Maker;Population;Process;programs;Provider;psychosocial;Quality of Care;Regulatory Affairs;Research;Research Methodology;Research Personnel;research study;Resources;Role;Safety;Scientist;statistics;Surveys;time use;Training Activity;training opportunity;U-Series Cooperative Agreements;Work;Workplace

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Precision Medicine;Prevention;Substance Misuse

ORG_NAME: GENETOBE INC.

PHR: PROJECT NARRATIVE Alcohol associated liver disease (AALD) is one of the major liver diseases with a high mortality rate but no effective drug treatment for AALD at present. Our project for the first time aims at developing a personalized genetic medicine for AALD, which has a great impact to both improving the human health and reducing social burden due to this deadly disease. We use novel and unprecedented approach in this project, which has a great potential to establish a new paradigm for drug develop for other common diseases.

PI_NAMEs: BISGAIER, CHARLES LARRY;LIU, WANQING  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Acetylgalactosamine;Alcohol consumption;Alcoholic Liver Diseases;Alleles;Amino Acids;Animals;Antisense Oligonucleotides;AODR mortality;Cessation of life;Chemistry;Chronic;Clinical;Clinical Research;Clinical Trials;comparative efficacy;Data;Death Rate;design;Development;Diet;Disease;disease phenotype;disorder subtype;DNA;Dominant-Negative Mutation;Dose Limiting;Down-Regulation;drug candidate;Drug Delivery Systems;drug development;Drug Kinetics;Drug or chemical Tissue Distribution;Ethanol;Etiology;Evaluation;Fatty Liver;FDA approved;Fibrosis;first-in-human;Formulation;Future;Genes;Genetic;Genetic Medicine;Genetic Polymorphism;genetic risk factor;Genetic Transcription;genome wide association study;genotoxicity;Goals;good laboratory practice;Good Manufacturing Process;Health;Hepatic;Hepatotoxicity;Histology;Human;human disease;human study;immunogenicity;improved;Individual;Inflammation;Interruption;Investigation;Investigational Drugs;Investigational New Drug Application;knock-down;Lead;Legal patent;Liver;Liver diseases;Liver Fibrosis;liver injury;liver transplantation;Malignant neoplasm of liver;manufacture;Manufacturer;Medical;meetings;Messenger RNA;Metabolism;Modeling;Modification;Molecular;Monkeys;mouse model;mutant;Mutation;Names;nonalcoholic steatohepatitis;nonhuman primate;novel;novel therapeutics;Oligonucleotides;overexpression;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Pharmacotherapy;Phase;phase 1 study;phase 2 study;Phenotype;Phospholipase;Plasma;Positioning Attribute;precision genetics;precision medicine;Precision therapeutics;Predisposition;Prevention;programs;Protein Isoforms;Proteins;prototype;quality assurance;Rattus;Research Contracts;RNA Interference;Rodent;Role;Safety;safety testing;screening;Single Nucleotide Polymorphism;small hairpin RNA;Small Interfering RNA;social;Specific qualifier value;Specificity;success;targeted treatment;Testing;Therapeutic;therapeutic target;Time;Toxic effect;Toxicology;treatment strategy;Treatment-related toxicity;Triglyceride Metabolism;Variant

PROJECT_TITLE: A Precision Medicine for Alcohol-Associated Liver Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Palliative Care

PI_NAMEs: WAGNER, JAMES R (contact)

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;American;Assisted Living Facilities;burnout;care providers;Caregivers;Caring;clinical care;cognitive interview;Communities;community setting;Community Surveys;Compensation;Complex;COVID-19 pandemic;Data;data infrastructure;Data Set;Data Sources;Dementia;dementia care;design;Device or Instrument Development;Discipline of Nursing;Elements;Ensure;evidence base;Family;Focus Groups;Foundations;Funding;Future;Goals;Health;health care quality;Health Personnel;Healthcare;Healthcare Systems;Home;implementation framework;improved;Individual;Infrastructure;innovation;Knowledge;Licensed Practical Nurse;Link;Long-Term Care for Elderly;Measurement;Medicaid;Medical;Medicare;Medicare/Medicaid;Methodology;Methods;Modeling;multidisciplinary;novel;Nurse Practitioners;Nurses;Nursing Homes;Occupations;Outcome;patient home care;payment;Persons;Physician Assistants;Physicians;Policies;Policy Maker;Population;practice setting;Procedures;Process;Provider;psychosocial;Public Health;Quality of Care;Questionnaires;Registered nurse;Research;Research Personnel;Resources;Retirement;Sampling;screening;Self Care;Source;Surveys;Testing;Time;tool;Training;Translating;Variant;Work

PROJECT_TITLE: Screening and Survey Instrument Development Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health;Violence Research

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE Child abuse and neglect (CAN) is a pressing and costly public health issue, and economic support policies may be effective strategies towards reducing CAN by strengthening families' economic well-being and reducing related stress. This proposed project will rigorously examine the impact of state-based economic support policies during and post COVID in preventing CAN, and engage families and service providers in how policies are implemented at the local level to identify effective CAN prevention strategies in community settings. Findings will inform states' selection and implementation of policies to prevent CAN and prepare the PI to engage in independent, community-based, and policy-relevant research.

PI_NAMEs: ZHANG, LIWEI  (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Advocacy;caregiving;Child;Child Abuse and Neglect;Child abuse prevention;Collaborations;Communities;Community Actions;community based participatory approach;community based participatory research;community based practice;community engagement;community setting;complex data;cost;County;COVID-19;COVID-19 pandemic;Data;Data Analyses;Data Linkages;design;Disasters;economic disparity;Economics;Ethnic Origin;experience;Experimental Designs;Family;flexibility;Food;Funding;Future;future pandemic;Goals;Grant;health inequalities;high risk;Housing;improved;Individual;innovation;knowledge base;kohl;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Missouri;Natural experiment;neglect;people of color;Personal Satisfaction;Policies;Policy Analysis;post-COVID-19;Poverty;prevent;Prevention;prevention practice;Prevention strategy;Process;programs;Public Health;Race;Recovery;Reporting;Research;Research Activity;Research Personnel;Resources;Risk;Rural;Security;Series;service providers;socioeconomics;Stress;stressor;success;synergism;theories;Training;Translating;United States National Institutes of Health;Variant;Visit

PROJECT_TITLE: State economic support policies on the prevention of child abuse and neglect during and post the COVID-19 pandemic: Bridging evidence with policy implementation

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Women's Health Research

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative The contribution of chromosomal sex in aging and Alzheimer's disease (AD) has been largely ignored. Yet, the development of sex-specific targets in aging and AD is an attractive therapeutic strategy to treat AD patients of both sexes. This project aims to investigate whether the E3 ubiquitin ligase HUWE1 which gene is located on the X chromosome escapes inactivation in aging and AD and to determine its sex-specific interactome in aging and AD.

PI_NAMEs: JUNG, SUNG YUN;TSVETKOV, ANDREY  (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: Affect;Age;age related;age related changes;aged;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Architecture;Area;Astrocytes;Binding;Brain;brain cell;cell type;Cells;Cerebellum;Child;Chromatin;Chromatin Structure;Clinical Research;crosslink;Data;Development;Disease;disease phenotype;DNA Damage;dosage;Down-Regulation;Endothelial Cells;entorhinal cortex;Estrogens;Event;Exhibits;Female;Foundations;frontal lobe;Genes;Genetic Transcription;genotypic sex;Gonadal Steroid Hormones;Hippocampus;Human;human female;Hyperactivity;Immunoprecipitation;Inflammation;Inherited;Intellectual functioning disability;Investigation;Knockout Mice;Lead;Link;Lipids;male;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Messenger RNA;Methods;Microglia;Mus;Mutation;Neonatal;Nerve Degeneration;neurodevelopment;Neurons;Pericytes;Persons;Phosphotransferases;Physiological;Play;Proteins;Regulation;Research Activity;response;Role;Severity of illness;sex;Sex Differences;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;sphingosine 1-phosphate;sphingosine kinase;tau Proteins;Tg2576;Therapeutic;Therapeutic Agents;transcription factor;Treatment Efficacy;ubiquitin-protein ligase;Ubiquitination;United States;Wild Type Mouse;Woman;women patients;X Chromosome;X Inactivation

PROJECT_TITLE: Contribution of HUWE1 to sex differences in aging and Alzheimer's disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


PI_NAMEs: MARCUS, STEVEN C (contact)

PROJECT_TERMS: Aging;Alzheimer's disease related dementia;Area;Assisted Living Facilities;Automobile Driving;care delivery;care outcomes;care providers;Caring;Censuses;Certification;Cessation of life;Characteristics;Clinical;clinical care;Collaborations;Communities;community based service;community setting;Data;data access;Data Collection;data exchange;data infrastructure;Data Linkages;data privacy;data resource;Data Security;Data Set;Data Sources;Dementia;dementia care;demographics;Discipline of Nursing;Electronic Health Record;Ensure;Environment;Ethics;Family;Goals;Guidelines;Health;health care service utilization;Health Personnel;Health Resources;Health Services Accessibility;Healthcare;Home;Hospitals;improved;Individual;insight;Institution;insurance claims;Investments;Leadership;Licensing;Link;Long-Term Care;Measures;Medicaid;Medicare;Medicare/Medicaid;Nurses;Nursing Homes;Outcome;patient home care;Patient-Focused Outcomes;Patients;Persons;Physicians;Policies;Policy Maker;Population;practice setting;preservation;Privacy;privacy protection;Process;Process Assessment;Provider;Public Health;Quality of Care;Research;Research Personnel;Resources;Respondent;Role;Source;Spouses;Surveys;Training;Variant;Work

PROJECT_TITLE: Administrative Data Transfer Masking, Access, and Ethics Core


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Rehabilitation;Telehealth

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Most Latinx childhood cancer survivors do not attain recommended amounts of physical activity and are generally sedentary, which increases their risk of chronic health conditions. This project in adolescent and young adult Latinx childhood cancer survivors whose preferred language is Spanish or English will culturally tailor and the test the efficacy of a new physical activity intervention consisting of a physical activity tracker integrated with individualized goal setting and a private social media group to improve physical activity, cardiovascular health, and quality of life. If efficacious, this portable and scalable intervention will fill a critical gap to reduce complications from cancer treatment among Latinx survivors.

PI_NAMEs: KADAN-LOTTICK, NINA S;MENDOZA, JASON A (contact)

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: Accelerometer;Adolescent and Young Adult;Age;arm;Behavior Therapy;cancer complication;Cancer Control;cancer recurrence;cancer risk;cancer therapy;cardiometabolic risk;cardiometabolism;Cardiomyopathies;Cardiopulmonary;cardiovascular health;childhood cancer survivor;Chronic;Communication;Communities;Control Groups;COVID-19 pandemic;culturally appropriate intervention;curative treatments;Diet and Nutrition;Dyslipidemias;efficacy testing;Enrollment;Evaluation;exercise intervention;Fatigue;Feedback;fitbit;fitness;Functional disorder;Funding;Future;General Population;Goals;Guidelines;Health;Health behavior;health related quality of life;Heart Rate;heart rate monitor;improved;Infrastructure;innovation;Instagram;instrument;Insulin Resistance;Intervention;intervention participants;Intervention Studies;Interview;Language;Late Effects;Latinx;Maintenance;Malignant Neoplasms;mHealth;Modeling;moderate-to-vigorous physical activity;Modification;novel;Obesity;Outcome;outcome disparities;Participant;participant enrollment;Patient Recruitments;Patient Self-Report;Patients;Pediatric Oncology Group;peer support;Phase;Physical activity;Physical Function;Population Sciences;portability;predictive marker;preference;Preparation;prevent;primary outcome;Privatization;Process;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;response;Rest;Risk;sedentary;Site;social;Social Functioning;social media;Spanish;Step Tests;Support Groups;Survivors;systematic review;Target Populations;Test Result;Testing;therapy development;Time;Treatment Efficacy;virtual

PROJECT_TITLE: Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_NAME: ORLANCE, INC.

PHR: PROJECT NARRATIVE Orlance’s Gene Gun uniquely enables needle-free delivery of DNA and RNA vaccines into the epidermis of the skin. We hypothesize that the ability of the gene gun to directly deliver DNA and RNA into cells in the epidermis will make it more effective than conventional intramuscular delivery of DNA and RNA vaccines in targeting tumor cells localized in the skin. Here, we will optimize gene gun delivery of DNA or RNA to identify a regimen that induces strong tumor specific immune responses and protection from melanoma in a mouse model.

PI_NAMEs: FRIZZELL, HANNAH  (contact)

PROGRAM_OFFICER_NAME: REGMI, SAROJ GOPAL

PROJECT_TERMS: Address;Adjuvant;Antibodies;Antigens;Antitumor Response;Blood;booster vaccine;cancer immunotherapy;cancer therapy;Cancer Vaccines;CD8-Positive T-Lymphocytes;Cells;Clinical;clinical development;Clinical Trials;comparative efficacy;Cryopreservation;Delivery Rooms;Development;Devices;Disadvantaged;DNA;DNA delivery;DNA Maintenance;DNA Vaccines;Dose;Dryness;Effectiveness;efficacy evaluation;Electroporation;Epidermis;Formulation;Freeze Drying;Future;gene gun;Genetic;Goals;Gold;gp100 Antigen;Human;Immune response;Immune Targeting;Immunization;immunogenicity;Immunotherapeutic agent;Immunotherapy;improved;individual patient;Intramuscular;Intramuscular Injections;Jet Injections;Lead;lipid nanoparticle;Malignant Neoplasms;Mediating;Melanoma;Melanoma Tumor;Melanoma Vaccine;Methods;Modality;Modeling;mouse model;Mucous Membrane;Mus;Muscle;nanoparticle delivery;Natural Killer Cells;Needles;neoantigen vaccine;neoantigens;neoplastic cell;next generation;novel;nucleic acid delivery;Nucleic Acid Vaccines;Nucleic Acids;Pain;Painless;particle;Phase;preclinical development;protective efficacy;prototype;Regimen;Research;response;RNA;RNA delivery;RNA vaccine;Site;Skin;Small Business Innovation Research Grant;T cell response;Technology;Temperature;Testing;Therapeutic;therapeutic evaluation;Time;Tissues;trafficking;Treatment Efficacy;tumor;Tumor-Infiltrating Lymphocytes;Vaccination;vaccine delivery;Vaccines;Work

PROJECT_TITLE: Next Generation Gene-Gun Delivered DNA and RNA Immunotherapeutic Vaccines for Melanoma.


PROJECT_TERMS: Address;Administrator;Alzheimer's disease related dementia;American;Assisted Living Facilities;care providers;Caring;clinical care;Communities;Competitive Bidding;Data;Data Collection;data infrastructure;data resource;Data Sources;Decision Making;Dementia;dementia care;design;Device or Instrument Development;Documentation;Elements;Ensure;evidence base;experience;Family;field survey;future implementation;Goals;Health Personnel;implementation research;Individual;insight;Institution;International;Intervention Studies;Interview;Leadership;member;Metadata;Methods;Michigan;Nursing Homes;Occupations;Participant;patient engagement;patient home care;Persons;Policy Maker;Population;Positioning Attribute;practice setting;Process;Provider;Quality Control;Questionnaires;Research;Research Personnel;Resources;Respondent;response;Role;Sampling;screening;Source;Standardization;Structure;Surveys;Techniques;U-Series Cooperative Agreements;Universities;user-friendly;Variant;Vendor;Work

PROJECT_TITLE: Data Collection, Linkages, Cleaning and Sharing Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences

PI_NAMEs: WAGNER, LAURA M (contact)

PROJECT_TERMS: Address;Advisory Committees;Affect;Alzheimer's disease related dementia;Assisted Living Facilities;Award;care providers;caregiving;Caring;Characteristics;clinical care;Committee Members;Communities;community building;community setting;Complex;complex data;Data;data infrastructure;data resource;Data Set;Data Sources;Dementia;dementia care;Development;doctoral student;Economics;Electronic Health Record;Ethics;experience;Family;Feedback;Funding;Future;Goals;health economics;Health Personnel;Health Services Research;home based service;improved;Infrastructure;innovation;insight;interest;Interview;Investigation;Investments;Knowledge;Learning;Light;Link;Living Arrangement;Medicare/Medicaid;Mentors;Mentorship;Modeling;novel;Nurses;Nursing Homes;Outcome;patient home care;payment;Persons;Physicians;Policy Maker;Population;practice setting;pre-doctoral;Publications;Qualitative Methods;Quality of Care;repository;Request for Applications;Research;Research Personnel;Research Project Grants;Research Proposals;research study;Resources;Scientist;Statistical Data Interpretation;Surveys

PROJECT_TITLE: Research Studies Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: The overarching goals of this research are to validate and improve personalized breast cancer risk assessment tools leveraging extensive mammographic, genetic, and epidemiologic/clinical data from large national cohorts, the Black Women’s Health Study and the Sister Study. We will apply methods in deep learning to mammographic images along with recent genetic risk assessment approaches to advance precise risk stratification while addressing critical gaps in the current evidence base. Findings from this study will inform screening and risk reduction strategies and ultimately help close the gap in racial disparities in breast cancer.

PI_NAMEs: BERTRAND, KIMBERLY A.;TEHRANIFAR, PARISA  (contact)

PROGRAM_OFFICER_NAME: DIVI, RAO L

PROJECT_TERMS: Address;Adoption;advanced breast cancer;algorithmic bias;Artificial Intelligence;Black race;black women;Breast;Breast Cancer Detection;Breast Cancer Prevention;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;breast density;Calibration;cancer subtypes;Classification;Clinical;clinical application;Clinical Data;clinical risk;cohort;Data;Data Set;deep learning;deep learning model;digital;Discrimination;Disease;Disparity;District of Columbia;Early Diagnosis;Electronic Medical Records and Genomics Network;Ensure;epidemiologic data;Epidemiology;Equity;Estrogen Receptor Status;Estrogen Receptors;Ethnic Origin;evidence base;Family;follow-up;Genetic;genetic resource;genetic risk assessment;genomic data;genomic tools;Genomics;Goals;Guidelines;health disparity;High Risk Woman;improved;Knowledge;Laws;Malignant Breast Neoplasm;Malignant Neoplasms;Mammographic Density;Mammography;Measures;Methods;Modeling;mortality;Not Hispanic or Latino;Notification;Outcome;Pathology;Performance;personalized screening;polygenic risk score;Population;Positioning Attribute;Prognosis;Publishing;Race;racial disparity;racial diversity;Recording of previous events;Reduce health disparities;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;Role;screening;Sister;Stage at Diagnosis;standard of care;Statutes and Laws;Stratification;study population;Testing;tool;tumor;uptake;Validation;White Women;Woman;Women's Health

PROJECT_TITLE: Advancing breast cancer risk prediction in national cohorts: the role of mammogram-based deep learning

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Methamphetamine;Prevention;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Public Health Significance: This study will address an important scientific gap by improving our understanding of the potential impact of structural interventions for HIV and substance use prevention for Black sexual and gender minorities. This work is consistent with National HIV/AIDS Strategy goals of reducing HIV- related health inequities and may be used to guide implementation of future HIV prevention interventions.

PI_NAMEs: HOTTON, ANNA  (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Address;Affect;AIDS prevention;Behavior;Behavioral;Black race;care outcomes;Caring;Collection;Communities;Complex;Computer Models;Computing Methodologies;Continuity of Patient Care;Data;Data Sources;Decision Making;Dependence;Disease;Disease Outcome;Disparity;Distal;Employment;Epidemic;Epidemiologic Methods;Epidemiology;Ethics;Evaluation;experimental study;Face;Feedback;Future;future implementation;Geographic Locations;Goals;Grant;health inequalities;HIV;HIV diagnosis;HIV/AIDS;Housing;housing instability;Illinois;implementation barriers;Imprisonment;improved;Individual;Inequity;insight;Intervention;Link;Measures;member;Mental Health;Methamphetamine;methamphetamine use;Methods;minority communities;model building;Modeling;opioid epidemic;opioid use;Outcome;Overdose;Parameter Estimation;Pattern;Persons;Policy Maker;polysubstance use;Prevention;Prevention Research;preventive intervention;Process;programs;Public Health;reduced substance use;Research;Resources;Risk;Science;Series;Sexual and Gender Minorities;Social Environment;social health determinants;social influence;social structure;Specific qualifier value;Statistical Methods;stressor;structural determinants;Structure;substance use;Substance Use Disorder;substance use prevention;success;System;Testing;therapy development;transmission process;trend;Uncertainty;Unemployment;uptake;virtual;vulnerable community;Work

PROJECT_TITLE: Computational modeling to evaluate socio-structural interventions for HIV and substance use


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

ORG_STATE: MA

PHR: Narrative Despite widespread recognition of the benefits associated with opioid agonist therapy, few persons with opioid use disorder (OUD) who need treatment are currently taking either buprenorphine or methadone and the prevalence of OUD and number of overdoses continues to escalate. A landmark study has provided high certainty evidence supporting the initiation of buprenorphine in emergency department (ED), yet uptake remains low. The objective of this proposal is to develop and test VR-Choice, an immersive virtual reality experience designed to motivate eligible patients to agree to treatment with buprenorphine in the ED.

PI_NAMEs: FRAENKEL, LIANA ;SOARES, WILLIAM EDWARD (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: Virtual reality at the point of care to increase uptake of MOUD in the ED

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Racial and Ethnic Minority Health Research;Regenerative Medicine;Social Determinants of Health;Telehealth;Transplantation

ORG_CITY: COLUMBUS

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE While much work has examined non-adherence in pediatric chronic illness, little is known about non-adherence in children with hematopoietic stem cell transplant (HSCT), and even less is known about how race and ethnicity affects medication non-adherence rates among HSCT recipients, however there are significant disparities in adherence among underserved minority groups. There is a critical need to evaluate novel mHealth approaches to promote equitable care and reduce health disparities among children receiving HSCT, particularly the growing numbers of Spanish-speaking families. Culturally appropriate, adapted digital interventions could be easily delivered to linguistically diverse families as a frontline approach to family education and care.

PI_NAMEs: SKEENS, MICAH  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Acute;Address;Adherence;adherence rate;Adoption;Adult;Affect;Age;Attention;bilingualism;Caregivers;Caring;chemotherapy;Child;Childhood;Chronic;Chronic Disease;Clinic;Clinical;clinical care;community advisory board;community based participatory research;community partners;Complex;Data;design;digital;digital health;digital intervention;Disparity;Dose;Education;Emergency department visit;Enrollment;Equity;ethnic diversity;Ethnic Origin;Ethnic Population;evidence base;Face;Family;Goals;graft vs host disease;Health;Health Care Costs;health disparity;health equity;Healthcare;Hematopoietic Stem Cell Transplantation;high risk;Hispanic Populations;Home;hospital readmission;Hospitalization;Immunosuppressive Agents;improved;individualized medicine;innovation;Intervention;Intervention Trial;Knowledge;Language;Latino;Latino Population;Linguistics;Malignant Childhood Neoplasm;marginalization;Measures;medication compliance;medication nonadherence;member;Methods;mHealth;mhealth interventions;Minority Groups;Mobile Health Application;Modeling;mortality;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;Oral;Organ Transplantation;Outcome;parent project;Patient Noncompliance;Patients;pediatric patients;Pharmaceutical Preparations;Phase;pilot test;Population;Population Heterogeneity;Positioning Attribute;post-transplant;prevent;Process;prospective;Provider;provider communication;Quasi-experiment;Race;Recommendation;Reduce health disparities;Regimen;relapse risk;Reporting;Research;Science;Site;Solid;Spanish;successful intervention;Symptoms;System;systematic review;Technology;Telephone;Testing;Time;Translating;Translation Process;Translations;Transplant Recipients;underserved minority;usability;Work

PROJECT_TITLE: Feasibility and Usability of a Spanish-Transcreated Pediatric Post-Transplant Adherence App (BMT4me)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Genetics;Maternal Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Rare Diseases;Stroke;Women's Health Research

ORG_CITY: DETROIT

ORG_DEPT: PEDIATRICS

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE  This proposal investigates the mechanisms of motor deficits of cerebral palsy and congenital tetrahydrobiopterin deficiency, which involve formation of destructive reactive chemical species in early brain injury resulting in cell death. New information about which forms of cell death, how they affect brain cells, and how effective potential therapies are in an animal model of cerebral palsy will be very valuable for future drug development in human studies.

PI_NAMEs: TAN, SIDHARTHA  (contact);VASQUEZ VIVAR, JEANNETTE M.;XU, JIE

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Abbreviations;Abruptio Placentae;Acute;Affect;Anabolism;Animal Model;antenatal;Antioxidants;Apoptosis;Biochemical;Birth;Brain;brain cell;Brain Hypoxia-Ischemia;Brain Injuries;Brain region;burden of illness;Carotid Arteries;Cause of Death;Cell Death;cell type;Cerebral Palsy;Chemicals;Child;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;coping;cost;Critical Pathways;Development;DHFR gene;Diffusion;Dihydrofolate Reductase;Discipline of obstetrics;Disease;Disorder of neurometabolic regulation;drug development;Early identification;Electron Microscopy;Electron Spin Resonance Spectroscopy;Electrons;Endoplasmic Reticulum;Enzymes;Equation;Ethidium;Etiology;Event;Failure;Family suidae;fetal;fetal brain injury;Fetus;fetus hypoxia;Flow Cytometry;Future;gene editing technology;Genes;GTP Cyclohydrolase I;Guide RNA;Heterozygote;High Pressure Liquid Chromatography;Homozygote;Human;human fetal brain;hydroethidine;inhibitor;Injury;innovation;insertion/deletion mutation;insight;Institution;interest;Iron Chelation;Knock-in;Knock-out;Lead;Ligation;Link;Lipid Peroxidation;Lipid Peroxides;liquid chromatography mass spectrometry;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Mammals;Mediating;Modeling;Motor;motor deficit;Muscle Hypertonia;Mutation;Necrosis;neuroimaging marker;Neuroprotective Agents;Nitric Oxide Synthase Type I;nonhuman primate;Oryctolagus cuniculus;Outcome;oxidant stress;Oxidants;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidative Stress Pathway;Pathogenesis;Pathway interactions;Patients;Pattern;Perinatal;peroxidation;Phenotype;phenyl-N-tert-butylnitrone;Phospholipids;Placental Insufficiency;postnatal;Predisposition;Pregnancy;prevent;Prevention;Prevention therapy;Principal Investigator;Propidium Diiodide;Quadriplegia;Recycling;Reperfusion Therapy;Resistance;Rhodamine 123;Rodent;Role;Scientific Inquiry;Sepiapterin reductase;sepiapterin reductase deficiency;Sheep;social;Societies;spasticity;Spectrum Analysis;Superoxides;Surrogate Markers;Suspensions;targeted treatment;Techniques;Testing;tetrahydrobiopterin;Tetrahydrobiopterin deficiency;Western Blotting

PROJECT_TITLE: Ferroptosis in knock-in sepiapterin reductase mutation rabbits

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;Human Genome;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_CITY: STANFORD

ORG_DEPT: BIOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: (No Change) The paraventricular nucleus of thalamus (PVT) to nucleus accumbens (NA) pathway is a potent target for preventing relapse, but its molecular mechanisms are largely unknown. We propose to use single cell transcriptomic profiling and imaging to identify opioid responsive cell types in both regions and its epigenomic mechanisms in the PVT. Our proposed studies will help identify novel targets for treating opioid addiction

PI_NAMEs: BINTU, BOGDAN ;CHEN, XIAOKE  (contact);ZHU, QUAN

PROGRAM_OFFICER_NAME: SATTERLEE, JOHN S

PROJECT_TERMS: 3-Dimensional;Abstinence;addiction;Affective;Anatomy;Animals;ATAC-seq;Atlases;base;Behavioral;Biological;Brain;Brain region;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Structure;Chronic;Complex;Cues;Data;Drug Addiction;drug craving;drug relapse;drug seeking behavior;Drug usage;Epigenetic Process;epigenomics;experimental study;Exposure to;feeding;fighting;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Image;Imaging technology;knock-down;Label;Learning;Long-Term Potentiation;Maintenance;Mediating;Memory;Methods;Modification;Molecular;Molecular Target;motivated behavior;multimodality;multiple omics;Mus;negative affect;Negative Reinforcer;neural network;Neurobiology;neuronal circuitry;Neurons;novel;novel strategies;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;opioid epidemic;opioid exposure;opioid mortality;opioid use;opioid user;opioid withdrawal;Pathway interactions;Pharmaceutical Preparations;Physiological;prescription opioid abuse;promoter;psychological symptom;Recommendation;Regulatory Element;Relapse;relapse prevention;Resolution;response;Retrieval;Role;Sampling;single cell analysis;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Sleep;Spatial Distribution;Structure;Structure of paraventricular nucleus of thalamus;Subgroup;Symptoms;Synapses;Synaptic Transmission;Text;transcriptome;transcriptomics;United States;Visualization;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Multi-modal profiling of spatially resolved cell types mediating opioid withdrawal


ADMINISTERING_IC: AT

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to public health because it seeks to create a research network to expand our understanding of how music-based interventions (MBIs) work to alleviate pain. The research network, comprised of a cross disciplinary team comprised music therapists, engineers, psychologists, social workers, and basic scientists, will also explore new, interesting ways to measure pain during music experiences. Thus, the proposed research is relevant to the part of the NIH’s mission to understanding and optimizing the use of MBIs to improve health.

PI_NAMEs: BURNS, DEBRA S (contact)

PROGRAM_OFFICER_NAME: CHEN, WEN G

PROJECT_TERMS: Absenteeism at work;Acceleration;Acute Pain;addiction;Address;Adult;Adverse effects;Adverse event;American;Analgesics;Anesthesia procedures;Applications Grants;Applied Research;Basic Science;Behavioral;Biological Assay;Biological Markers;biopsychosocial;chronic pain;chronic painful condition;Clinical;clinical practice;Clinical Research;Clinical Trials;Complement;Complex;Data;Data Set;Development;Dimensions;Educational workshop;Effectiveness;effectiveness trial;Electrophysiology (science);Employment;Engineering;experience;Financial Hardship;Foundations;Funding;Future;Health;Health Care Costs;Homelessness;Image;improved;Integrative Therapy;interest;Intervention;Intervention Studies;Link;Measurement;Measures;Mediating;Medicine;meetings;Methodology;Methods;Mission;Modeling;Music;Music Therapy;neurophysiology;Neurosciences;new technology;non-opioid analgesic;novel;Operative Surgical Procedures;Opioid;Outcome;Pain;Pain management;Pain Measurement;Pain Nature;pain outcome;Pain Research;Paper;Pathway interactions;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacologic Substance;Phase;Pilot Projects;Policies;preference;Procedures;Process;Productivity;Professional Organizations;programs;prospective;Psychologist;Psychology;Psychometrics;psychosocial;Psychosocial Factor;Public Health;Recommendation;Reporting;Research;Research Personnel;Research Priority;response;Risk;Role;Science;scientific organization;Scientist;Secure;side effect;social;Social Work;Social Workers;societal costs;Structure;Techniques;Technology;Testing;Therapeutic Effect;therapy development;Translating;Unemployment;United States National Institutes of Health;webinar;Work;working group;Writing

PROJECT_TITLE: Music mechanisms and technologies network: Integrative models to address pain through music


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Contraception/Reproduction;Data Science;Genetics;Human Genome;Infertility;Regenerative Medicine;Women's Health Research

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The goal of this project is to build living models of the human endometrium to mimic the phase of the menstrual cycle where human embryo implantation normally occurs. Using samples from consented patients, and combining them with microfluidics, tissue engineering, single cell genomics, spatial transcriptomics, and proteomics, we test they ways the in vitro models faithfully capture the features of the human endometrium and its response to the changes in hormones that mature then endometrium as it prepapres to host an embryo. These models can be used to compare patients with and without certain diseases, like heavy menstrual bleeding or recurrent pregnancy loss, and to develop therapies for these and other conditions.

PI_NAMEs: GRIFFITH, LINDA G (contact);LAUFFENBURGER, DOUGLAS A;VENTO-TORMO, ROSER

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Atlases;bench to bedside;Biological Models;Blood Vessels;cell type;Cells;Coculture Techniques;Communities;Complex;Consent;Cues;cytokine;Data;Data Set;Decidual Cell Reactions;design;Development;Devices;Disease;Dissemination and Implementation;Embryo;Embryonic Development;Endometrial;endometrial organoid;Endometrium;Endothelial Cells;Endothelium;Ensure;Environment;Epithelial Cells;Epithelium;Fostering;Gland;Glean;Goals;Growth Factor;Gynecology;Hemorrhage;Heterogeneity;Hormonal;Hormones;Human;human model;Hydrogels;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo evaluation;Industrialization;Infertility;insight;Invaded;Investigation;iterative design;Knowledge;Maps;Menstrual cycle;Microfluidic Microchips;Microfluidics;microphysiology system;model building;Modeling;monolayer;Morphogenesis;Mucous Membrane;Multiomic Data;Myeloid Cells;natural Blastocyst Implantation;Natural Killer Cells;Natural regeneration;Nature;Nutrient;Organoids;Patients;Periodicity;personalized medicine;Phase;Phenotype;physiologic model;Physiological;Play;Positioning Attribute;Pre-Clinical Model;Pregnancy loss;Pregnancy Maintenance;preservation;Process;Proteomics;Protocols documentation;Recurrence;regenerative;Regulation;Reproducibility;Reproduction;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;single cell genomics;Site;Source;spatiotemporal;Specific qualifier value;Stromal Cells;Structure;Surface;Systems Biology;Technology;Testing;therapy development;Time;Tissue Engineering;Tissues;tool;trafficking;transcriptomics;Uterine cavity;Work

PROJECT_TITLE: Integrating tissue engineering and microfluidics to model the spatial niches of the human endometrium in vitro with guidance from in vivo multiomics data


NIH_SPENDING_CATS: Aging;Arthritis;Genetics;Osteoarthritis

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE The proposed research is relevant to public health because of the critical need for more effective treatments for osteoarthritis (OA), which is a common disease with a large societal impact. This work focuses on the role of DNA damage and cellular senescence in chondrocytes and synovial cells and is expected to contribute new knowledge on the mechanisms responsible for the development of OA. These findings will support future novel interventions to prevent, slow, and treat this disease of the joint that is often painful and debilitating.

PI_NAMEs: DIEKMAN, BRIAN O (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Age;age effect;age related decline;Aging;Alleles;Antibodies;Apoptosis;arthropathies;Automobile Driving;Biological Assay;Cadaver;Cartilage;cartilage cell;Cell Aging;Cell Cycle;Cell Cycle Arrest;Cell Physiology;Cells;Chondrocytes;Chronic Disease;Clustered Regularly Interspaced Short Palindromic Repeats;Comet Assay;Computer Models;Data;Degenerative polyarthritis;Development;disability;Disease;DNA Damage;DNA Repair;DNA strand break;effective therapy;Elderly;ellipticine;Endonuclease I;experimental study;Flow Cytometry;Functional disorder;Future;Goals;Harvest;Hip region structure;Histologic;Human;Image;improved;in vivo;Indirect Immunofluorescence;Inflammatory;innovation;Intervention;Intra-Articular Injections;irradiation;joint injury;Joints;Knowledge;Link;Measures;Medial meniscus structure;Mediating;Mediator;Methods;Methyl Methanesulfonate;Modeling;Mus;novel;old mice;Operative Surgical Procedures;Outcome;Pain;Pathologic;Physiological;Play;Predisposition;Prevalence;prevent;Prevention;Production;Proteins;Public Health;repaired;Replacement Arthroplasty;Reporter;Research;response;Risk Factors;Role;senescence;senescence associated secretory phenotype;senescent cell;Signal Pathway;Sirtuins;Site;small molecule;Societies;Source;Stains;Stimulus;Stress Response Signaling;stressor;Synovial Cell;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Time;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: Role of DNA damage and cellular senescence in osteoarthritis pathophysiology

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cancer;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Lung;Lung Cancer;Natural Products;Palliative Care;Patient Safety;Prevention;Rural Health;Substance Misuse;Therapeutic Cannabinoid Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: NARRATIVE Cancer patients are increasingly using a diverse set of cannabis and cannabinoid products to treat cancer- related symptoms, despite limited evidence of beneficial effects and largely unknown risk. This study, which is a collaboration with the NCI Community Oncology Research Program (NCORP), will measure the complex variability of the real-life context of cannabis and cannabinoid use among a large cohort of cancer patients recruited through NCORP clinics across the U.S. We will longitudinally assess the impact of these complexities on the course of cancer care, from diagnosis through the treatment experience, providing critical evidence to inform future clinical trials and practice-based recommendations.

PI_NAMEs: REBOUSSIN, BETH A. (contact);ROMERO-SANDOVAL, E. ALFONSO;WAGONER, KIMBERLY G.

PROGRAM_OFFICER_NAME: FILIPSKI, KELLY

PROJECT_TERMS: active method;Acute;Address;Adult;Adverse effects;Affect;Age;Anxiety;associated symptom;Benefits and Risks;cancer care;Cancer Patient;cancer therapy;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;cannabis use behavior;Characteristics;chemotherapy;Clinic;Clinical;clinical practice;Clinical Trials;cohort;Collaborations;Colorectal Cancer;Communities;Community Clinical Oncology Program;Community Networks;community-level factor;comorbidity;Complex;Coupled;Cross-Sectional Studies;Data;debilitating symptom;design;Diagnosis;dosage;Dose;Drug Interactions;Drug Prescriptions;Effectiveness;Engineering;Environment;Ethnic Origin;experience;Fatigue;Frequencies;Future;Goals;Hematology;Hepatotoxicity;Heterogeneity;Immune checkpoint inhibitor;Immune response;Immunosuppression;improved;Individual;Inflammatory;inflammatory marker;inter-individual variation;Interferon Type II;Intoxication;Kidney;Legal;Licensing;Life;Liver;Longitudinal Studies;Lymphocyte;Lymphocyte Count;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;marijuana legalization;marijuana use;marijuana user;Marketing;Measures;Medicine;Melanoma;Metabolism;National Cancer Institute;Nausea and Vomiting;Neuropathy;neuropsychiatric symptom;Newly Diagnosed;Non-Hodgkin's Lymphoma;Non-Small-Cell Lung Carcinoma;Opioid;Outcome;Participant;Patient Recruitments;Patients;Pattern;Perception;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;physical symptom;Plasma;Population;Prevalence;programs;Provider;Quality of life;Race;Recommendation;Recording of previous events;Recreation;recruit;reduce symptoms;Regimen;Regulation;Reporting;Research;Risk;Role;Rural;Sample Size;Sampling;Serious Adverse Event;Severities;sex;Smoke;Subgroup;Surveys;Symptom Burden;symptom management;Symptoms;Therapeutic;Time;Toxic effect;Treatment-related toxicity;tumor;Uncertain Risk;United States National Academy of Sciences;vaping

PROJECT_TITLE: Assessing Benefits and Harms of Cannabis and Cannabinoid Use Among a Cohort of Cancer Patients Treated in Community Oncology Clinics


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative Leukemia stem cells are responsible for poor clinical outcomes in patients with acute myeloid leukemia, and the proposed research addresses a need to better understand the mechanisms that underlie their function. We recently discovered that the cell surface marker CD99 promotes leukemia stem cell self-renewal by constraining protein synthesis, establishing a new link between regulated protein synthesis and leukemia stem cell function. By elucidating the mechanisms underlying why leukemia stem cells depend on regulation of protein synthesis across different subtypes of acute myeloid leukemia, this project has the potential to establish a new paradigm for how cancer stem cells sustain themselves, as well as to guide the design of more effective therapies targeting leukemia stem cells to improve clinical outcomes for patients with acute myeloid leukemia.

PI_NAMEs: CHUNG, STEPHEN SHIU-WAH (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adopted;BCL2 gene;Biogenesis;biological adaptation to stress;Blood Cells;cancer stem cell;Cell surface;Cells;Clinic;Clinical;cytotoxicity;Dependence;design;Development;Disease;effective therapy;Evaluation;Exhibits;Gene Expression Profile;Gene Mutation;Generations;Genetic;genetic manipulation;Genetically Engineered Mouse;Goals;Green Fluorescent Proteins;Hematopoietic stem cells;high risk;Human;Impairment;improved;in vivo;inhibitor;innovation;insight;Knowledge;leukemia;leukemic stem cell;Link;Maintenance;Malignant Neoplasms;Measures;Mediating;Modeling;Molecular;Monoclonal Antibodies;mouse model;novel;novel therapeutic intervention;novel therapeutics;Outcome;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;prevent;Process;progenitor;programs;Protein Biosynthesis;Protein Synthesis Inhibition;Proteins;proteotoxicity;Recurrent disease;Regulation;Reporter;Research;Resistance;response;Ribosomal Proteins;ribosome profiling;Ribosomes;Role;self-renewal;stem cell exhaustion;stem cell function;stem cell model;stem cell self renewal;stem cells;stemness;Stress;System;targeted treatment;Testing;Therapeutic;therapy development;therapy resistant;Toxic effect;Transcript;transcriptome sequencing;Translating;Translations;Tumor Suppressor Proteins;Work;Xenograft procedure

PROJECT_TITLE: Regulation of Protein Synthesis in Leukemia Stem Cells

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Legalization of cannabis has led to the proliferation of new cannabis products with various modes of administration (e.g., vaping, edibles, dabbing, blunts) with differing THC potency and health risks for pregnant women; yet, we know little about how women use cannabis pre- and during pregnancy, whether modes vary with socio-demographics or local cannabis policies, or how modes relate to cannabis use frequency, cannabis use disorder (CUD), polysubstance use, quitting cannabis use in pregnancy, or adverse health outcomes. In a mixed-methods study of ~310,000 racially and ethnically diverse pregnancies screened for prenatal substance use by self-report and urine toxicology testing within Kaiser Permanente Northern CA (KPNC) from 2021-2026, this research will examine socio-demographic and policy correlates of modes of use pre- and during pregnancy, test how modes relate to the risk of daily use, CUD, polysubstance use, substance use disorders (SUD), quitting pre- or during pregnancy, addiction treatment, and cannabis-related psychiatric and medical outcomes, and conduct interviews with women who used cannabis before and/or during pregnancy. Together, results will have immediate public health and clinical implications, providing important data to identify potentially actionable areas for future prevention and intervention efforts to reduce harms associated with prenatal cannabis use.

PI_NAMEs: YOUNG-WOLFF, KELLY CORINNE (contact)

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: addiction;Address;Age;Anemia;Anxiety;Area;Asthma;Behavior;black women;California;Cannabis;cannabis administration;Cannabis policy;Cannabis retail;Chemicals;Child;Clinical;clinical practice;Cohort Studies;COVID-19 pandemic;Data;density;Development;Diabetes Mellitus;Disparity;early pregnancy;Electronic Health Record;ethnic diversity;experience;Exposure to;fetal;Fetal health;First Pregnancy Trimester;Frequencies;Future;Guidelines;Harm Reduction;Health;Hispanic Women;Home;Hypertension;innovation;insight;Integrated Health Care Systems;Intervention;Interview;Knowledge;Legal;Literature;low socioeconomic status;Maps;marijuana legalization;Marijuana Smoking;marijuana use;marijuana use disorder;marijuana use in pregnancy;Maternal Health;maternal marijuana use;Mediating;Medical;Mental Depression;Methods;Moods;Mothers;National Institute of Drug Abuse;Nausea;neonatal outcome;Nicotine;non-smoking;Outcome;Pain;Patient Self-Report;Patients;Pattern;Policies;polysubstance use;Population Heterogeneity;Pregnancy;Pregnant Women;Premature Birth;prenatal;Prenatal care;prenatal testing;prepregnancy;Prevention;Proliferating;Public Health;racial diversity;Regulation;Reporting;reproductive;Research;Research Design;Resources;Risk;screening program;Smoke;Smoking;sociodemographic factors;sociodemographics;Subgroup;substance use;Substance Use Disorder;Symptoms;Testing;Tetrahydrocannabinol;Toxicology;Urine;vaping;Variant;Waxes;Woman;young woman

PROJECT_TITLE: Modes of Cannabis Administration and Polysubstance Use among Women Before and During Pregnancy

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In Philadelphia, government and community partnerships have resulted in structural interventions to remediate vacant lots, abandoned buildings, and dilapidated homes to improve neighborhood disorder; these interventions have shown significant positive impacts on neighborhood crime and mental health. This study will examine the impact of these highly-innovative interventions on opioid misuse and fatal and nonfatal opioid overdose. Findings will provide support for expanding neighborhood disorder remediation projects in Philadelphia and promote similar public health-based policy and community-level health interventions for opioid overdose prevention in other cities.

PI_NAMEs: NESOFF, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: NICKS, SHANNON ELIZABETH

PROJECT_TERMS: Address;Affect;Behavioral Risk Factor Surveillance System;Black Populations;Black race;Cities;Communities;community partnership;cost effective;Crime;Data;Data Collection;design;Deterioration;Development;Diagnosis;Disease;Disparity;Distal;Drug usage;Drug user;Economics;Emergency department visit;Emergency Situation;Epidemic;Ethnic Origin;Fentanyl;fentanyl use;Government;Grant;Green space;gun violence;Harm Reduction;Health;Heroin;heroin use;Home;Hospitals;Housing;improved;Infrastructure;injection drug use;innovation;Intervention;Investments;Low income;Measures;Medical Examiners;Mental Depression;Mental Health;Methods;Minority;Modeling;Monitor;Naloxone;Neighborhoods;Not Hispanic or Latino;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose prevention;overdose risk;Pharmaceutical Preparations;Philadelphia;Policies;Poverty;Prevalence;prevent;Process;programs;Property;Public Health;public health intervention;Race;Racial Segregation;Randomized, Controlled Trials;remediation;repaired;Reporting;Research;Research Proposals;Resources;Risk;social;social capital;social cohesion;social determinants;social observations;Stress;Structure;synthetic opioid;Syringes;System;Time;Tourniquets;Translations;violent crime;Work;wound care

PROJECT_TITLE: The Impact of Community Infrastructure Reinvestment Programs on Opioid Misuse and Opioid Overdose


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Estrogen;Mental Health;Neurosciences;Women's Health Research

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Aggression is an evolutionarily conserved, adaptive component of social behavior that, in certain circumstances, can become escalated thereby threatening lives, increasing the risk of developing psychiatric disease in victims and incurring tremendous economic burdens to society. Despite this, we have a limited understanding of neural mechanisms that drive aggression vs. pro-social behavior, particularly in females. In this application, we take a novel data driven approach to predict aggression-related brain networks and then test casual hypotheses about their role in aggressive vs pro-social behavior.

PI_NAMEs: RUSSO, SCOTT JAMES (contact)

PROGRAM_OFFICER_NAME: BREEDEN, ANDREW LEE

PROJECT_TERMS: Adult;Affect;Aggressive behavior;Amygdaloid structure;Anxiety;Atlases;Automobile Driving;Behavior;Behavioral;Behavioral Model;Biological;Brain;brain cell;Brain region;cell type;Cells;Complex;conditioned place preference;Data;data mining;design;Desire for food;Economic Burden;Electrophysiology (science);Ensure;Environment;ESR1 gene;Female;Fright;Genetic;Glutamates;Health;Histologic;Hypothalamic structure;Image;Immediate-Early Genes;in vivo;interest;Investigation;Maintenance;male;Maps;Mediating;Mental disorders;Methods;Modeling;Motivation;Mus;Nature;Network-based;neural;neural circuit;neuromechanism;Neurons;novel;optogenetics;Pathway Analysis;Pattern;Personal Satisfaction;Population;pre-clinical;Psychological reinforcement;Regulation;Resources;Rewards;Risk;Role;Series;sex;Sex Differences;sexual dimorphism;social;Social Behavior;Social Interaction;Societies;Surrogate Markers;Symptoms;Testing;Tissues;women versus men

PROJECT_TITLE: Sex Differences in Neural Circuit Mechanisms of Aggression

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Ovarian Cancer;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Identifying and understanding genetic risk factors driving ovarian cancer disparities is critical to improve risk assessment, treatment paradigms, and patient outcomes. The Wnt ligand WNT4 is an underexplored risk factor, as we find that a common single nucleotide polymorphism (SNP) at the WNT4 locus activates WNT4 signaling and drives therapy resistance, while the divergent frequency of this SNP across ethnic populations suggests that the variant underpins cancer disparities in ovarian cancer risk and outcomes. Defining the functional consequence of WNT4 in gynecologic cancers is essential to understand disease risk and etiology, develop precision treatments, and address cancer health disparities linked to the WNT4 variant allele.

PI_NAMEs: BITLER, BENJAMIN G;SIKORA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Adjuvant Chemotherapy;Affect;African;ARID1A gene;Asian;Asian population;Attenuated;Automobile Driving;Binding Sites;Biology;California;Canada;cancer cell;Cancer Cell Growth;Cancer cell line;Cancer Etiology;cancer health disparity;Cancer Model;Cancer Patient;cancer risk;cancer subtypes;Caucasians;Cell Line;Cell Respiration;Cell Survival;Cell Therapy;Chemoresistance;chemotherapy;Cisplatin;Clear cell carcinoma;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Colorado;CRISPR/Cas technology;Data;defined contribution;Dependence;Disease;disorder risk;Disparity;East Asian;Ethnic Origin;Ethnic Population;Etiology;Female Genital Neoplasms;Foundations;Frequencies;Gene Frequency;Genes;Genetic;Genetic Polymorphism;genetic risk factor;genetic variant;genome-wide;Genotype;glucose metabolism;Goals;Growth;Gynecologic;Gynecologic Pathology;Human;human data;improved;In Vitro;in vivo;Incidence;knock-down;Knock-in;Knock-in Mouse;Latinx;Latinx population;Ligands;Link;lipid metabolism;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;Metabolic;Metabolism;metabolomics;Mitochondria;Modeling;Mus;Neoadjuvant Therapy;novel;novel therapeutics;Nuclear Receptors;Organogenesis;Outcome;outcome disparities;Ovarian;Ovarian Clear Cell Tumor;overexpression;patient subsets;Patient-Focused Outcomes;Patients;Phenotype;Population;population based;Precision therapeutics;programs;Protein Array;Protein Array Analysis;protein metabolism;Regulation;Resistance;Risk;Risk Assessment;Risk Factors;Role;Signal Transduction;Single Nucleotide Polymorphism;Site;Small Interfering RNA;Specimen;therapy resistant;Tissues;transcription factor;treatment response;tumor;Tumor Tissue;tumorigenesis;Variant;WNT4 gene;Woman;Work

PROJECT_TITLE: Elucidating a novel WNT4 regulatory axis as a driver of gynecologic cancer health disparities

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


NIH_SPENDING_CATS: Aging;Genetics

ORG_CITY: Boulder

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative A fundamental question in biology is why cells age and permanently cease to divide, a process called cellular senescence. The proposed project uses modern, single-cell technologies to characterize the onset of senescence, to determine how senescence relates to a transient state of cell-cycle withdrawal called quiescence, and to develop a molecular framework that can predict a cell’s likelihood of re-entering the cell cycle and its physiological age. Since chronological age is the major predictor for most human diseases, the proposed work could impact the treatment of multiple diseases by developing treatments to slow or even reverse human aging.

PI_NAMEs: SPENCER, SABRINA LEIGH (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Age;Aging;Algorithms;Biological Markers;Biology;cancer therapy;cell age;Cell Aging;Cell Culture Techniques;Cell Cycle;Cell Cycle Progression;Cell division;cell injury;Cell Physiology;Cell Separation;Cells;chemotherapeutic agent;Chronic Disease;Chronology;Development;Disease;DNA Damage;Drug usage;Event;Flow Cytometry;Functional disorder;genetic signature;Genotoxic Stress;genotoxicity;hallmarks of aging;Health Care Costs;Human;human disease;human old age (65+);improved;inflammatory milieu;Knowledge;Length;Light;Malignant Neoplasms;Measures;Medical;Microscopy;Modeling;Modernization;Molecular;molecular marker;Morbidity - disease rate;mortality;Nature;Pathology;Pharmaceutical Preparations;Physiological;Population;predictive signature;prevent;Probability;Process;Proliferating;Regenerative capacity;Rejuvenation;Relapse;reproductive;Rest;Role;Safety;senescence;senescent cell;senolytics;sensor;single cell technology;single-cell RNA sequencing;Somatic Cell;Sorting;Technology;telomere;telomere damage;Testing;Therapeutic;transcriptomics;tumor;Withdrawal;Work

PROJECT_TITLE: Progressive states of cell-cycle withdrawal

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: BALTIMORE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Ischemic stroke is the most frequent cause of long-term severe disability and places an enormous economic burden on society. A critical aspect in guiding treatment decisions is determining the penumbra, i.e., the region of injured brain tissue around the ischemic core that can potentially be revived. The overarching goal of this proposal is investigating the use of hyperpolarized 13C metabolic imaging in a novel endovascular pig stroke model as a new tool for improved detection of stroke penumbra that can be translated into the clinic.

PI_NAMEs: JANOWSKI, MIROSLAW ;MAYER, DIRK  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Academia;acute stroke;Affect;Alteplase;Animal Model;Autopsy;Bicarbonates;Biological Models;Blood flow;Brain;Brain Injuries;brain tissue;Cerebral hemisphere hemorrhage;Cerebrum;Citric Acid Cycle;Clinic;Clinical;clinical care;Clinical Trials;clinically relevant;Complement;Data;Decarboxylation;Detection;Development;Diffusion;Diffusion Magnetic Resonance Imaging;disability;Drops;Economic Burden;Eligibility Determination;Energy Metabolism;Evolution;Family suidae;Functional disorder;Future;Glucose;Glycolysis;Goals;Histology;Image;imaging modality;Imaging Techniques;Impairment;improved;in vivo;Industry;Infarction;Injections;Injury;innovation;insight;Intervention;Ischemia;ischemic injury;Ischemic Stroke;Link;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Malignant - descriptor;Mammals;Maps;Measurement;Measures;Mechanics;Metabolic;metabolic imaging;Metabolic Pathway;Metabolism;Methods;Microdialysis;molecular imaging;neuroimaging;Noise;novel;novel strategies;Nuclear;Oxygen;Pathology;Patients;Perfusion;pharmacologic;Play;Population;porcine model;post stroke;Procedures;Process;Pyruvate;pyruvate dehydrogenase;Pyruvate Metabolism Pathway;real-time images;Reperfusion Injury;Reperfusion Therapy;Reporting;Resolution;response;Risk;Role;Scanning;Selection for Treatments;Signal Transduction;Societies;spectroscopic imaging;Stroke;stroke model;stroke patient;stroke therapy;structural imaging;Surrogate Markers;Therapeutic;therapeutic evaluation;therapy outcome;Thrombectomy;Time;Tissues;tool;Translating;Urea

PROJECT_TITLE: Hyperpolarized 13C metabolic imaging in an endovascular swine model of ischemic stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Computerized clinical decision support (CDS) offers a promising strategy to standardize and scale evidence- based practices to keep pace with the dynamic nature of the opioid crisis and overcome barriers to addiction treatment. To change practice, CDS must be useful, usable, integrated into routine care delivery, and supported by a multicomponent implementation strategy. We will refine and evaluate the uptake, usability, and equity of a nationally disseminated multicomponent CDS intervention to increase treatment initiation in the emergency care of people with opioid use disorder.

PI_NAMEs: MELNICK, EDWARD ROBERT (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Accident and Emergency department;Achievement;addiction;Address;Adoption;analog;Biometry;Buprenorphine;care delivery;Caring;Characteristics;clinical decision support;Cluster randomized trial;comparative efficacy;computerized;Consumption;Data;data infrastructure;effective intervention;effectiveness evaluation;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Medicine;Equity;Evaluation;Event;evidence base;Evidence based practice;experience;Feedback;Fentanyl;health equity;Health Services Accessibility;Illicit Drugs;implementation research;implementation science;implementation strategy;improved;innovation;Intervention;Measurement;Measures;Medicine;Methods;multiphase optimization strategy;Mus;Nature;novel;Nurses;opioid epidemic;opioid overdose;opioid use disorder;Outcome Measure;Pain management;Pathway interactions;Patients;Persons;Physicians;prescription opioid;Prevalence;Randomized;randomized trial;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reproducibility;Resources;routine care;Sentinel;Speed;Standardization;success;support tools;Testing;Time;treatment disparity;uptake;usability;Variant;Vendor;Withdrawal

PROJECT_TITLE: ADAPT: Adaptive Decision support for Addiction Treatment


ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: ATTAGENE, INC.

PHR: Title: Assigning mode of action to phenotypically discovered anticancer leads . Narrative. Developing drugs from natural sources is difficult because we don't know how they work. Here, we use advanced Attagene's technology to create a new method to understand the mechanism of action of anticancer compounds from fungi. If it works, it could make it much easier to develop new anticancer drugs.

PI_NAMEs: MAKAROV, SERGEI S (contact);OBERLIES, NICHOLAS H.

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Acute;anti-cancer;anticancer activity;Antineoplastic Agents;Biochemical;Bioinformatics;Biological Assay;Biology;bioprocess;Categories;Cells;chemical genetics;Chemical Structure;Chemicals;Collaborations;Collection;Complex;Consumption;cost;Data;Data Set;Development;drug development;drug discovery;economic value;Evaluation;FDA approved;follow-up;fungus;Genes;Image;in silico;interest;Libraries;Link;Methods;Natural Products;Natural Source;Nature;novel;novel anticancer drug;novel strategies;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Pilot Projects;preclinical development;Process;Proteomics;Research;Research Personnel;response;scaffold;screening;Services;Signal Pathway;Structure;System;Systems Biology;Techniques;Technology;Time;transcription factor;transcriptomics;wasting;Work;Yeasts

PROJECT_TITLE: Assigning mode of action to phenotypically discovered anticancer leads.


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cardiovascular;Clinical Research;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Computer tomography (CT) scans are a common diagnostic test ordered for patients. The goal of our research is to apply artificial intelligence (AI) models to CTs to measure structural features of abdominal organs and tissues. We will then determine if organ and tissue changes are associated with organ-specific disease, hospitalization, and death.

PI_NAMEs: RULE, ANDREW DAVID (contact);ST SAUVER, JENNIFER LYNN

PROGRAM_OFFICER_NAME: EL KASSAR, NAHED

PROJECT_TERMS: Abdomen;abdominal CT;abdominal fat;Adult;Affect;Age;age acceleration;age difference;age related;Aging;aging population;aging related;Aorta;Archives;artificial intelligence model;biological age;Biological Markers;Biology of Aging;Blood;Body Composition;bone;Bone Density;brain magnetic resonance imaging;calcification;Calendar;Cardiovascular Diseases;Cardiovascular system;Cessation of life;Chronic;Chronic Kidney Failure;Chronology;Cirrhosis;Classification;Clinical;clinical diagnosis;clinical practice;cohort;Cyst;Data;Databases;deep learning;deep learning model;density;Diagnostic tests;Disease;disease classification;DNA Methylation;Early Intervention;End stage renal failure;Epidemiology;Ethnic Population;Event;Fatty acid glycerol esters;follow-up;Frequencies;General Population;Goals;Health;high risk;Hospitalization;human old age (65+);Image;image archival system;improved;International Classification of Disease Codes;Ischemic Bowel Disease;Kidney;Kidney Diseases;Laboratories;Laboratory Finding;Length;Liver;living kidney donor;Lower Extremity;Magnetic Resonance Imaging;Measures;Medical Records;Methods;mortality;Muscle;Older Population;Organ;Outcome;Pancreas;Patients;peer;Peripheral arterial disease;Persons;Physical Function;Population;population based;Population Study;prognostic;Race;racial difference;Records;Reference Values;Renal Artery Stenosis;Research;Resolution;Resources;Risk;Sampling;Scanning;sex;Sex Differences;Skeletal Muscle;Symptoms;System;telomere;Testing;Tissue Model;Tissues;tool;trend;United States;Variant;X-Ray Computed Tomography

PROJECT_TITLE: A population-based study of deep learning derived organ and tissue measures for accelerated aging using repurposed abdominal CT images

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cancer;Colorectal Cancer;Digestive Diseases;Networking and Information Technology R&D (NITRD);Nutrition;Physical Activity;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Uncertainty in exposure measurements is a major source of bias in epidemiologic research aimed at elucidating causal relationships between risk factors, such as physical activity, in relation to cancer incidence and mortality, and misclassification of cancer incidence induces additional bias in studies based upon electronic health record data and other administrative ‘big data’ sources of information, such as Medicare claims data. We will develop novel epidemiological methods for valid and efficient estimation of nutritional and lifestyle effects on cancer risk, from estimation of relative risks related to within-individual change in lifestyle exposures to resolving challenges arising in the study of physical activity, diet, co-morbidities and health behaviors in relation to cancer risk due to measurement uncertainty, and apply these new methods to studies arising in the American Cancer Society’s Cancer Prevention Study II, Harvard’s Nurses' Health Study, the National Cancer Institute’s IDATA, Harvard’s Women’s and Men’s Lifestyle Validation Studies, and Yale New Haven’s Epic EHR data. With a major emphasis on methods dissemination, publicly available user-friendly software will accompany all new methods, a massive online open course (MOOC) will be developed, and short courses will be offered at national and international epidemiology and statistics conferences.

PI_NAMEs: SPIEGELMAN, DONNA L;WANG, MOLIN  (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Acceleration;Address;Adult;Alcohol consumption;American Cancer Society;anti-cancer research;attenuation;Behavior;Big Data;Biological Markers;Birth;cancer epidemiology;Cancer Etiology;cancer prevention;Cancer Prevention Study II;cancer risk;Child;clinical practice;Clinical Treatment;cohort;Cohort Studies;Colorectal Cancer;colorectal cancer risk;Communities;comorbidity;Complex;Computer software;course development;Data;design;Development;Diabetes Mellitus;Diet;dietary;Disease;Electronic Health Record;energy balance;Energy Intake;Epidemiologic Methods;Epidemiologist;Epidemiology;epidemiology study;Etiology;experience;Exposure to;Faculty;follow-up;Hand;Health;Health behavior;Heterogeneity;Hospitals;improved;Incidence;Individual;Infant;innovation;interest;International;Investments;lectures;Life Style;Malignant Breast Neoplasm;Malignant Neoplasms;Manuals;massive open online courses;Measurement;Measures;Medicare claim;men;method development;Methodology;Methods;mortality;National Cancer Institute;Negative Finding;Non-Insulin-Dependent Diabetes Mellitus;novel;Nurses' Health Study;nutrition;Nutritional;Outcome;Paper;Participant;Patient Self-Report;Pattern;Pharmaceutical Preparations;Physical activity;Policies;Population Research;Prevalence;Procedures;Process;prospective;Public Health;Questionnaires;Recovery;recruit;Relative Risks;Research;research to practice;Risk Estimate;Risk Factors;Role;sedentary lifestyle;Seminal;Sleep;software development;Source;statistics;Structure;symposium;Talents;theories;Time;Translations;Uncertainty;United States National Institutes of Health;user friendly software;user-friendly;Validation;validation studies;Variant;web site;webinar;Woman;Work

PROJECT_TITLE: New Epidemiologic Methods for Reducing Measurement Error and Misclassification Bias in Cancer Epidemiology

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: NARRATIVE These experiments study an enzyme known as RAG that performs an essential function in the development of the immune system but which occasionally makes mistakes and generates aberrations in human chromosomes that can contribute to the development blood cancers such as lymphoma and leukemia. This work studies how RAG and evolutionarily related enzymes cut DNA and interact with the human genome with the goal of discovering the causes of these mistakes and methods by which they could be prevented.

PI_NAMEs: SCHATZ, DAVID G. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Address;Alleles;anti-toxin;Antigen Receptors;Architecture;B-Cell Development;Biochemical;Biochemistry;Biological;Biological Assay;Biology;Cell Line;Cells;Chimeric Proteins;Chromatin;Chromosome Pairing;Closure by clamp;Complex;Coupled;Cryoelectron Microscopy;Dangerousness;design;Development;DNA;DNA Binding;Elements;endonuclease;Engineering;Ensure;Enzymes;Ephrin-A5;Event;Evolution;experimental study;Family;fascinate;Functional disorder;Funding;Genome;Genome Stability;Genomic Instability;Genomics;genotoxicity;Goals;Heart;Hematopoietic Neoplasms;Human Chromosomes;Human Genome;Immune system;In Vitro;in vitro Model;in vivo;Insertional Mutagenesis;insight;Integration Host Factors;Invertebrates;Jaw;Label;Lead;Left;leukemia/lymphoma;Link;Lymphocyte;Lymphoid;Malignant Neoplasms;Mediating;Methods;Modeling;Molecular;Mus;Mutagenesis;mutant;novel;Outcome;prevent;Protein Biochemistry;Proteins;Publishing;Rag1 Mouse;Receptor Gene;recombinase;reconstitution;Recording of previous events;Regulation;Site;structural biology;Structure;T-Lymphocyte;Testing;tool;Toxin;Transposase;tumorigenesis;V(D)J Recombination;Work

PROJECT_TITLE: Function and Evolutionary Origins of the RAG Endonuclease

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: PROJECT NARRATIVE The generation of genetic data from human birth defects is rapidly increasing. However, determining what DNA sequence changes are responsible for these disorders is a major challenge. We will identify changes in DNA sequences that control gene activity in birth defect patients and perform experiments to determine if these sequence changes caused the observed conditions.

PI_NAMEs: PENNACCHIO, LEN ALEXANDER (contact);VISEL, AXEL

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Address;Affect;Alleles;analysis pipeline;analytical method;Animals;Biological Assay;Body System;Brain;brain malformation;candidate selection;Catalogs;Categories;causal variant;Cells;Chromatin;cloud based;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Complement 2;Congenital Abnormality;Conserved Sequence;Data;Data Set;de novo mutation;Defect;Development;developmental disease;Diagnosis;Diagnostic;Disease;Distant;DNA Sequence;Elements;Embryonic Development;Engineering;Enhancers;epigenomics;Etiology;exome sequencing;experimental study;Gene Expression;Generations;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;genetic variant;Genome;genome annotation;Genome engineering;genome sequencing;Genomics;Histopathology;Human;human data;Human Genome;Human Resources;in vivo;in vivo evaluation;innovation;International;Knock-in;Knock-in Mouse;Manuals;Maps;Modeling;mouse genome;mouse model;Mus;mutant;Mutate;Mutation;Organ;Pathology;Patients;Perinatal;Phenotype;prenatal;prevent;Reporter;Resolution;response;risk variant;RNA analysis;screening;Site;Structural Congenital Anomalies;Technology;Testing;therapeutic development;Tissues;transcriptome sequencing;Transgenic Mice;Transgenic Organisms;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Evaluating the Impact of Mutations in Distant-Acting Enhancers in Structural Birth Defects

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


NIH_SPENDING_CATS: Aging;Genetics;Hematology;Rare Diseases

ORG_NAME: JOSLIN DIABETES CENTER

PHR: Narrative  The model organism C. elegans has proven to be invaluable for discovery of mechanisms that influence aging and metabolism. Here we will build upon our recent work in C. elegans to determine how the master gene regulator SKN-1A/Nrf1 responds to the unsaturated fat oleic acid to benefit the organism and increase lifespan. We will also determine how stress in the protein synthesis machinery alters metabolism, and why this gene regulator is then protective, work that will provide fundamental insights into mechanisms that maintain protein synthesis and may suggest strategies for treating the human genetic disease Diamond- Blackfan anemia.

PI_NAMEs: SCHAFFER, JEAN E. (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: acid stress;Acids;Affect;Aging;Amino Acids;biological adaptation to stress;Biological Process;Caenorhabditis elegans;Cell Culture Techniques;Cells;Data;Diamond-Blackfan anemia;Dimensions;Disease;Erythroid;experimental study;extend lifespan;Fatty acid glycerol esters;Fatty Acids;feeding;Funding;Genetic Diseases;Genetic Transcription;Health Benefit;Health Promotion;Homeostasis;Human;human disease;Human Genetics;Impairment;improved;In Vitro;in vivo;insight;knock-down;life span;lipidomics;Lipids;Longevity;Maintenance;Mammals;Mediating;Membrane;Metabolic;Metabolism;metabolomics;model organism;Modeling;Monounsaturated Fatty Acids;multicatalytic endopeptidase complex;Mutation;nrf1 protein;Oleic Acids;Organism;Orthologous Gene;Pathway Analysis;Pathway interactions;Phenotype;Proteasome Inhibition;Protein Biosynthesis;proteostasis;Regulator Genes;response;Ribosomal Proteins;Ribosomes;ribosomopathy;Signal Transduction;Site;stable isotope;Stress;Supplementation;Testing;Tissues;transcription factor;Translations;treatment strategy;Triglycerides;Unsaturated Fats;Work

PROJECT_TITLE: Homeostasis functions of SKN-1A/Nrf1

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]