NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Pancreatic cancer is a lethal disease that is projected to become the leading cause of cancer-related death in the United States by 2030. The bulk of the pancreatic tumor volume is composed of a reactive and immunosuppressive fibroinflammatory stroma that hinders the efficacy of checkpoint-based immunotherapy in the treatment of these tumors. The goal of this proposal is to define the role of interleukin-33 in maintaining this immunosuppressive milieu through its regulation of macrophages.

PI_NAMEs: DONAHUE, KATELYN LOIS (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Affect;antitumor effect;Binding;Biological Assay;Cancer Biology;Cancer Etiology;candidate identification;CD8-Positive T-Lymphocytes;Cells;Cessation of life;Chromatin;Communication;Complement;Complex;Coupled;CRISPR/Cas technology;cytokine;Cytometry;Data;Disease;Disease Progression;experimental study;extracellular;Fibroblasts;Focal Adhesion Kinase 1;Genetic Transcription;Genetically Engineered Mouse;Goals;Growth;Growth Factor;Human;immune checkpoint blockade;Immunosuppression;immunosuppressive macrophages;Immunotherapy;Implant;implantation;improved;In Vitro;in vitro Assay;in vivo;Individual;Infiltration;Interleukin-2;Interleukins;Investigation;KRAS oncogenesis;Lesion;Ligands;Literature;Macrophage;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;mast cell;Mediator;Migration Assay;Modeling;mouse model;Mus;Nature;neoplastic cell;novel therapeutics;Organ;Pancreas;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Paracrine Communication;Patient-Focused Outcomes;Patients;Phenotype;Population;premalignant;receptor;recruit;Regulation;response;Role;Sampling;Signal Pathway;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;STAT3 gene;Stromal Cells;Subgroup;Survival Rate;T-Cell Activation;Techniques;Testing;Therapeutic;Time;Tissues;trend;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion;Tumor Volume;Tumor-associated macrophages;Tumor-Derived;Tumor-infiltrating immune cells;United States;Up-Regulation;Work

PROJECT_TITLE: Regulation and role of fibroblast-derived interleukin-33 in the pancreatic tumor microenvironment


ADMINISTERING_IC: DA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: MENLO PARK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SRI INTERNATIONAL

ORG_STATE: CA

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10-year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: BAKER, FIONA C (contact);MULLER-OEHRING, EVA M

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 10/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT SRI


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

ORG_STATE: MD

PHR: PROJECT NARRATIVE Malaria affects over two billion people, killing over 400,000 individuals each year mostly children in Africa. A powerful tool is needed for eliminating Plasmodium falciparum malaria from defined geographical areas. The ideal tool would be a highly effective, long-acting vaccine that prevents infection, disease and parasite transmission. This proposal describes our attempt to create designer PfSPZ candidates that possess superior breadth, magnitude and durable protective efficacy over the currently available strategies. The deliverables at the conclusion of the project would be improved PfSPZ vaccine candidate(s) poised for further downstream process development and future clinical evaluation in humans.

PI_NAMEs: SIM, B. KIM LEE (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Adjuvant;Affect;Africa;African;Antibodies;Antigens;Area;Asia;Asian;Attenuated;Biological Models;Cellular Immunity;Child;Clinical Trials;cost;Cryopreservation;Culicidae;Development;Disease;Distant;Dose;East Coast Fever;Europe;Exhibits;Falciparum Malaria;Future;Generations;Genetic;Genetic Crosses;Genetic Engineering;Genetic Variation;Geographic Locations;Geography;Glycolipids;Goals;Hepatocyte;Human;Hybrids;Immune response;Immunize;immunogenicity;improved;in vivo;Individual;Infection prevention;Licensing;Liver;Macaca mulatta;Malaria;manufacture;Monkeys;mosaic;Mus;Mutation;new technology;next generation;nonhuman primate;novel;overexpression;Parasites;parity;Performance;Persons;Phase;Plasmodium falciparum;Plasmodium falciparum vaccine;Pneumococcal vaccine;Prevnar;Process;Production;protective efficacy;Proteomics;Radiation;research clinical testing;response;Route;Safety;Source;Sporozoite vaccine;Sporozoites;tool;transcription factor;transmission process;Vaccination;vaccine candidate;vaccine efficacy;Vaccine Production;Vaccines;Vertebral column

PROJECT_TITLE: Expanding the breadth, magnitude, and durability of PfSPZ vaccines by creating multi-strain vaccines, designer hybrid and genetically altered parasite vaccines and use of a unique adjuvant.


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Diabetes;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Narrative Type 1 and type 2 diabetes (T1D and T2D), gestational diabetes (GDM) and related complications are excellent disease models to study the utility of polygenic risk scores (PRS) for predicting heterogenous and complex health outcomes in a setting where dramatic racial/ethnic and socioeconomic disparities exist. To address the disparities in PRS across ancestries, we have assembled a multi-disciplinary team to aggregate and analyze the largest existing genetic data from more than 1.8 M individuals (35% non-European) with T1D, T2D, GDM and glycemia-related complications and quantitative traits to improve the PRS prediction of diabetes and progression across the lifespan in diverse ancestries. Accomplishing the aims of this proposal will demonstrate how genomic data can inform more efficient and targeted preventive strategies within healthcare systems and across ethnically diverse populations.

PI_NAMEs: MANNING, ALISA KNODLE;MERCADER, JOSEP MARIA (contact);NG, MAGGIE

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Address;Bayesian Method;biobank;Biological Process;clinical risk;cohort;Collection;Complex;Coupled;Data;data harmonization;data sharing;Development;Diabetes Mellitus;diabetes risk;Diabetic Nephropathy;Diabetic Retinopathy;Disease;disease model;disorder risk;disorder subtype;Disparity;diverse data;Electronic Health Record;ethnic disparity;ethnic diversity;Ethnic Population;European ancestry;Genetic;genetic approach;genetic risk factor;genetic variant;genome wide association study;genome-wide;genomic data;Genomics;Genotype;Gestational Diabetes;global health;Goals;Health;health disparity;Healthcare Systems;improved;Individual;Informatics;Insulin-Dependent Diabetes Mellitus;large datasets;Life Cycle Stages;life span;Linkage Disequilibrium;method development;Methods;multidisciplinary;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Patient Care;Performance;personalized care;Persons;Phenotype;phenotypic data;polygenic risk score;Population;Population Heterogeneity;precision medicine;predictive tools;Prevention strategy;Process;racial disparity;racial population;Research;Risk Factors;risk prediction;Sampling Studies;Scoring Method;Secure;Societies;socioeconomic disparity;statistics;System;Testing;Training;trait;type I and type II diabetes;Variant;Visualization;Weight;Work

PROJECT_TITLE: Development of Polygenic Risk Scores for Diabetes and Complications across the Life-Span in Populations of Diverse Ancestry


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: This work will determine how the enzymes that mediate short chain fatty acid metabolism limit colon cancer progression, and demonstrate that their reduced expression drives tumorigenesis. We will test the possibility that lower enzyme expression specifically in colon tumor cells creates a therapeutic vulnerability by altering both metabolic and gene expression programs. We will exploit this vulnerability in colon cancer to develop novel combinatorial therapeutic approaches that target metabolism and gene expression.

PI_NAMEs: BAUER, TODD W;WOTTON, DAVID  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acceleration;Acetates;Acetyl Coenzyme A;Acetylation;Agar;Anchorage-Independent Growth;Binding;Butyrates;cancer cell;Cancer Model;Carcinogens;Cells;chemical carcinogen;Chromatin;Citrates;Coenzyme A Ligases;Colon;colon cancer cell line;colon cancer patients;colon cancer progression;Colon Carcinoma;colon tumorigenesis;Colonic Adenoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer progression;combinatorial;Control Locus;Data;Disease-Free Survival;Disseminated Malignant Neoplasm;DNA Damage;Environment;Enzymes;Epigenetic Process;Epithelium;fatty acid metabolism;Gene Expression;Genes;Genetic Transcription;Glycolysis;Glycolysis Inhibition;Growth;gut bacteria;gut microbiota;Histone Acetylation;Human;Impairment;Left;Link;Lipids;Malignant Neoplasms;Mediating;Metabolic;Metabolic Control;Metabolism;Mitochondria;Modeling;mouse model;Mus;mutant;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Nuclear;Phenotype;Predisposition;Process;Production;programs;Proliferating;Protein Acetylation;recruit;restraint;Role;Source;targeted treatment;Testing;Therapeutic;therapeutic target;Transferase;tumor;Tumor Burden;tumor progression;Tumor stage;tumorigenesis;tumorigenic;Volatile Fatty Acids;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: The role of ACSS2 in colon cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: MI

PHR: Tens of thousands of veterans have heart failure with preserved ejection fraction (HFpEF), and suffer poor quality of life, frequent hospitalizations, and high death rates. Older veterans and those with high blood pressure, obesity, and the metabolic syndrome (abnormal cholesterol and resistance to insulin's effects) are particularly at risk for HFpEF. However, it is not clear why only some veterans in this risk group eventually develop HFpEF. Extensive information from experimental animal models and some human studies suggests that dietary patterns in vulnerable `salt-sensitive' people could contribute to the risk for HFpEF. Reducing salt intake and increasing overall dietary quality in at-risk veterans could prevent heart and blood vessel damage that ultimately leads to HFpEF. Reducing the development of HFpEF, which currently has no definitive treatment, is highly relevant to the VA's mission to emphasize prevention of disease and population health.

PI_NAMEs: HUMMEL, SCOTT L (contact)

PROJECT_TERMS: Adherence;Adoption;Adverse effects;Advocate;Affect;Age;American Heart Association;Animal Model;Animals;arterial stiffness;arterial tonometry;Biological Markers;Biopsy;Blood Pressure;Blood Tests;Blood Vessels;Buffers;Cardiac;Cardiovascular Abnormalities;cardiovascular risk factor;Cardiovascular system;Cholesterol;clinically actionable;Cohort Studies;Consumption;Counseling;DASH diet;Data;Death Rate;Development;Diagnosis;Diet;Diet Modification;dietary;dietary control;Dietary Factors;Dietary Practices;dietary restriction;Dietary Sodium;disorder prevention;Dyslipidemias;Eating;Echocardiography;EFRAC;Endothelium;Epidemiology;Evidence based treatment;Exhibits;experience;Experimental Animal Model;Experimental Models;Femur;functional decline;Functional disorder;General Population;Glycocalyx;Goals;Health;Heart;Heart Atrium;Heart Diseases;Heart failure;heart function;high risk population;Home;Hospitalization;Hour;Human;Hypertension;hypertensive;hypertensive heart disease;Impairment;improved;in vivo;Incidence;Individual Differences;Inflammation;innovation;Insulin;Insulin Resistance;Intake;Intervention;Knowledge;Left;Left Ventricular Mass;lifestyle intervention;Link;Measures;Mediating;men;Metabolic syndrome;Microscopy;Microvascular Dysfunction;middle age;Mission;motivational enhancement therapy;novel;Obesity;older adult;Outpatients;Oxidative Stress;Participant;Pathway interactions;Patients;Pattern;Persons;Phase;phase 1 study;Phenotype;Physiologic pulse;Physiological;Population;Population Attributable Risks;population health;Populations at Risk;potential biomarker;preservation;Prevalence;prevent;Prevention;Prevention strategy;Preventive;primary outcome;programs;Public Health;Quality of life;Randomized;Recommendation;Research;Resistance;response;Risk;Risk Factors;salt intake;salt sensitive;Sodium;Sodium Chloride;Syndrome;System;Systemic hypertension;tailored messaging;Testing;Time;urinary;Ventricular;ventricular hypertrophy;Veterans;Visit;Woman

PROJECT_TITLE: Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome

STUDY_SECTION: CARA

STUDY_SECTION_NAME: Cardiovascular Studies A[CARA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Narrative The goal of this study is to provide knowledge for bacterial cellular processes including cell division, transcription and phage lysis using E. coli as a model system. As these processes are essential for survival and conserved across the bacterial kingdom, a better understanding will promote more effective development of new antibiotics targeting this process to combat infectious diseases caused by pathogenic bacteria.

PI_NAMEs: XIAO, JIE  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Antibiotics;Bacterial Infections;Bacteriophages;Biochemical;Biological Models;Cell division;Cell Physiology;Cell Wall;Cells;Cellular biology;combat;Communicable Diseases;Complex;Cytolysis;Cytoplasm;Development;DNA;DNA-Directed RNA Polymerase;Escherichia coli;Genetic Transcription;Genome;Goals;insight;interest;Knowledge;Laboratories;model organism;Molecular;molecular imaging;pathogenic bacteria;Positioning Attribute;Process;Proteins;Regulation;Research;single molecule;transcription factor;treadmill;Work

PROJECT_TITLE: Spatial Organization and Regulation of Bacterial Cellular Processes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: TR

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PI_NAMEs: KOTTON, DARRELL N. (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Administrator;Area;bench to bedside;Biomedical Engineering;Biomedical Research;Boston;cell bank;cell repository;Clinical;clinical practice;clinical translation;Cohort Studies;Competence;Complex;Congresses;Creativeness;Critical Thinking;Development;Discipline;disease model;education research;Educational process of instructing;Ethics;experience;Face;Faculty;Familiarity;Genes;Goals;Home;Human;In Vitro;innovation;Institution;Mentors;Mission;National Research Service Awards;novel;open source;Oral;Organoids;patient population;Patients;Pluripotent Stem Cells;Postbaccalaureate;Postdoctoral Fellow;pre-doctoral;precision medicine;programs;Protocols documentation;regenerative;Regenerative Medicine;Research;Resources;Risk;Science;Scientist;stem cell biology;stem cells;Student recruitment;TNFSF15 gene;Training;Training Programs;Translational Research;Universities;Writing

PROJECT_TITLE: NRSA Training Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Hematology;Immunotherapy;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE Graft versus host disease (GVHD) of the gastrointestinal (GI) tract is one of the major complications associated with allogeneic hematopoietic stem marrow transplantation (HSCT), and leads to significant morbidity and mortality. The goal of this project is to critically examine the role of an inflammatory cytokine, termed interleukin 23, in the pathophysiology of GVHD in the GI tract. The ultimate objective of this proposal is to demonstrate that blocking the action of this cytokine reduces the severity of this complication in patients undergoing allogeneic HSCT for the treatment of hematological malignancies.

PI_NAMEs: DROBYSKI, WILLIAM R. (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acute;Acute Graft Versus Host Disease;Address;Affect;Alloantigen;Allogenic;Antibodies;Antigen-Presenting Cells;arm;Attenuated;Bone Marrow Transplantation;CD8B1 gene;chronic graft versus host disease;Clinic;Clinical;clinically significant;Colon;Complication;Correlative Study;Critical Pathways;cytokine;design;Development;Digestive System Disorders;Disease;disorder prevention;experimental study;Functional disorder;gastrointestinal;Gastrointestinal tract structure;Genetic;Goals;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic;Hematopoietic Stem Cell Transplantation;Human;immune reconstitution;Immune system;improved;Incidence;Inflammation;Inflammatory;inflammatory milieu;insight;interleukin-23;Intestinal Graft Versus Host Disease;Mediating;microbial;microbiome;Morbidity - disease rate;mortality;mouse model;Mus;novel;novel strategies;novel therapeutic intervention;Organ;Pathologic;Pathway interactions;Patients;Phase;Phase II Clinical Trials;Play;Population;post-transplant;pre-clinical;preservation;Prevention;Prevention approach;Prevention strategy;Production;Regulatory T-Lymphocyte;Relapse;response;Role;Severities;Severity of illness;Signal Pathway;Signal Transduction;Site;Source;stem;T cell reconstitution;T-Lymphocyte;Therapeutic Effect;Tissues;Transgenic Mice;Translating;Transplant Recipients;transplantation therapy

PROJECT_TITLE: Blockade of IL-23 for the Prevention of Graft Versus Host Disease

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Kidney Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE The proposed research is relevant for patients with aggressive renal cell carcinoma because it will explore the molecular and genetic routes to disease progression, metastatic dissemination and response to therapy. The project is relevant to the mission of the NIH because it will shed light on a new opportunity to intervene therapeutically in this disease that currently has dismal outcomes and very limited therapy options, and it will expand our knowledge of the biology and context-specific vulnerabilities of renal cell carcinoma.

PI_NAMEs: GENOVESE, GIANNICOLA  (contact)

PROGRAM_OFFICER_NAME: BENAVIDEZ, JUSTIN MICHAEL

PROJECT_TERMS: addiction;Address;Aggressive behavior;Automobile Driving;base;Basic Science;Behavior;behavior prediction;Biological Markers;Biological Models;Biology;Cancer Biology;cancer cell;cancer genomics;Cancer Patient;cancer therapy;Cells;chemotherapy;Chromosomal Instability;Chromosome abnormality;Clinic;Clinical;Clinical Course of Disease;Clinical Oncology;clinical predictors;Clonal Evolution;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Dependence;design;Development;Disease;Disease Progression;Drug resistance;Drug Targeting;Ecosystem;effective therapy;Endowment;Epigenetic Process;Epithelial Cells;Epithelium;Event;Evolution;Face;functional genomics;Genetic;Genetic Engineering;genome editing;genome-wide;Genomic approach;Genomics;Goals;Heterogeneity;host neoplasm interaction;Human;human disease;Immunotherapy;improved;in vivo;innovation;Intervention;Investigation;Knowledge;Label;Malignant - descriptor;Malignant Neoplasms;Mesenchymal;Mesenchymal Differentiation;Metaplasia;Mission;Modeling;Modernization;Molecular;mosaic;neoplastic cell;Neurofibromin 2;new therapeutic target;novel;Oncologist;Outcome;Pathologic;Patients;Pattern;personalized approach;pharmacologic;Phenotype;Physiology;Population;Population Dynamics;premalignant;pressure;Primary Neoplasm;programs;Recurrent disease;Regimen;Renal Carcinoma;Renal Cell Carcinoma;renal epithelium;repaired;Reporter;Reporting;Research;Resolution;response;Role;Route;Sarcomatoid Features;Sarcomatoid Renal Cell Carcinoma;screening;Site;Specific qualifier value;standard of care;Suicide;System;targeted treatment;Technology;Therapeutic;Therapeutic Intervention;therapy resistant;Time;Tissues;tool;transcriptomics;transdifferentiation;Translational Research;treatment response;tumor;tumor heterogeneity;tumor progression;United States National Institutes of Health;Work

PROJECT_TITLE: Investigation of the role of epithelial-mesenchymal plasticity in renal cell carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-N(55)R]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Immunization;Infectious Diseases;Sexually Transmitted Infections;Urologic Diseases;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative The proposed studies will directly test for a protective effect of rectal CT on genital tract infection in a NHP model. We will characterize the host response to rectal CT infection, compare rectal CT immune profiles in the NHP model to those in humans, and utilize antibody functional assays to reveal how antibodies against CT may protect from reinfection or disease. This work will determine whether rectal CT infection confers protective immunity in primates.

PI_NAMEs: PATTON, DOROTHY L (contact);VOJTECH, LUCIA N

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Address;Affect;Animals;Antibodies;Antibody Response;Antibody titer measurement;Attenuated;Bacteria;Bacterial Sexually Transmitted Diseases;Biological Assay;Blood;CD4 Positive T Lymphocytes;Cells;Chlamydia;Chlamydia trachomatis;chlamydia vaccine;Circulation;Clinic;Clinical;Clinical Research;Data;design;Disease;Effector Cell;Epithelial Cells;experimental study;Eye;Fc Receptor;Female;Fostering;Future;gastrointestinal infection;Gastrointestinal tract structure;genital infection;Genitalia;Genitourinary system;Goals;High Prevalence;Human;Immune;Immune response;Immune system;Immunity;Immunologics;Infection;Inflammation;Interferon Type II;Lung;Macaca;Macaca nemestrina;male;Measures;Mediating;men;Methods;Modeling;Monkeys;Morbidity - disease rate;mouse model;Mucosal Immune Responses;Mucosal Immunity;Mucous Membrane;Mus;Natural History;Nature;nonhuman primate;Oropharyngeal;Outcome;Pathology;patient response;Patients;prevent;Primates;programs;protective effect;Public Health;Rectum;reproductive tract;Risk;Role;Sampling;Sexually Transmitted Diseases;Shapes;Site;Study models;T cell response;T-Lymphocyte;Testing;Time;United States;urogenital tract;vaccination strategy;vaccine strategy;Vaccines;Women's Group;women's morbidity;Work

PROJECT_TITLE: Coordinated studies in monkeys and humans to assess the immunological impact of rectal Chlamydia trachomatis infection on protection against genital infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cancer;Clinical Research;Genetics;Immunotherapy;Prostate Cancer;Urologic Diseases

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will lead to the development of clinically useful biomarkers for therapeutic monitoring of prostate cancer, as well as a better understanding of lineage plasticity in prostate cancer. These advances are expected to ultimately lead to improvements in the treatment of patients with prostate cancer. Thus, the proposed research is relevant to the part of the NCI’s Scientific Priorities that pertains to treating cancer.

PI_NAMEs: MADAN, RAVI AMRIT;TONER, MEHMET  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: androgen independent prostate cancer;Androgen Receptor;Biopsy;Biopsy Specimen;Blood;cancer cell;Cancer Patient;Castrate sensitive prostate cancer;Cell Separation;Cells;Clinical;clinical biomarkers;clinical center;clinical development;Clinical Trials;Collaborations;Collection;design;Development;Disease;DNA analysis;DNA Sequence Alteration;docetaxel;Evaluation;Evolution;Exposure to;Extramural Activities;EZH2 gene;Frequencies;Future;General Hospitals;Genetic Transcription;Genomics;Goals;Immune;Immune response;Immuno-Chemotherapy;Immunotherapy;immunotherapy trials;improved;Incidence;innovation;insight;Leukapheresis;liquid biopsy;Malignant neoplasm of prostate;Malignant Neoplasms;Massachusetts;Metastatic Prostate Cancer;Methods;Microfluidic Microchips;Microfluidics;Molecular;Molecular Analysis;Molecular Profiling;Monitor;multidisciplinary;Neoplasm Circulating Cells;Neoplasm Metastasis;neuroendocrine phenotype;Neuroendocrine Prostate Cancer;Neurosecretory Systems;next generation;novel;novel strategies;Outcome;participant enrollment;Patients;Pattern;Phenotype;precision oncology;prevent;Process;prostate biopsy;Prostate Cancer therapy;protein biomarkers;Public Health;rare cancer;RB1 gene;refractory cancer;Research;Research Project Grants;Resources;standard of care;Systemic Therapy;targeted treatment;Technology;Therapeutic;Time;Tissues;tool;TP53 gene;transdifferentiation;Translational Research;treatment response;tumor;tumor DNA;United States National Institutes of Health

PROJECT_TITLE: Microfluidic isolation and molecular analysis of circulating tumor cells for the study of neuroendocrine transdifferentiation in prostate cancer


ADMINISTERING_IC: MH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is highly heritable and marked by aberrant brain and behavioral development as early as 6 months of age, however it is unknown how genetic liability for ASD impacts infant development. This study aims to characterize how quantitative measures of genetic liability for ASD – including heritable autistic traits in first degree relatives and polygenic risk scores in infants – relate to trajectories of brain and behavioral development from 6 months of age through the period of early diagnosis at 24 months. Understanding the impact of genetic liability for ASD on neural and behavioral development reveals important mechanistic insight into the pathogenesis of ASD, and potentially identifies targets and timing for early intervention.

PI_NAMEs: GIRAULT, JESSICA BULLINS (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Age Months;Area;Attention;autism spectrum disorder;autism symptoms;autistic children;Behavioral;behavioral phenotyping;Biometry;Brain;brain behavior;Brain imaging;career;career development;Child;Clinical;clinical practice;Complex;Data;de novo mutation;Development;Diagnosis;Diagnostic;Disease;Early Diagnosis;Early Intervention;Epidemiology;experience;Family;Family member;First Degree Relative;Genes;Genetic;Genetic Diseases;genetic epidemiology;Genetic Variation;Goals;Heritability;Human;imaging study;improved outcome;indexing;Individual;Individual Differences;infancy;Infant;Infant Development;Inherited;insight;Intervention;Joints;Knowledge acquisition;Language;Learning;Life;Link;Measures;Mental disorders;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Molecular Genetics;Nature;neural;Neurodevelopmental Disorder;neuroimaging;neuropsychiatric disorder;Neurosciences;novel strategies;Outcome;Parents;Pathogenesis;Pathogenicity;Pattern;Pediatrics;Phenotype;phenotypic data;polygenic risk score;Population;Positioning Attribute;Postdoctoral Fellow;proband;Process;programs;Prospective Studies;Psychiatry;Quantitative Genetics;Research;Research Personnel;Research Project Grants;Research Proposals;Risk;risk variant;Shapes;Siblings;Site;Surface;Time;tool;Training;training opportunity;Universities;Variant;Washington;white matter;Work

PROJECT_TITLE: Genetic Liability for Autism and Infant Brain and Behavioral Development

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


PHR: PROJECT NARRATIVE EGFR mutations are the most common targetable mutations in non-small cell lung cancer (NSCLC) and there are highly effective FDA-approved drugs for patients who have the “typical” EGFR mutations (exon 19 deletion or exon 21 L858R), but there are no effective FDA-approved drugs for the vast majority of patients with “atypical” mutations in EGFR exon 18 or 20. We recently reported the structural features of exon 20 mutations that cause steric hindrance and prevent FDA-approved drugs from inhibiting the receptor effectively, and identified poziotinib as a drug with activity in exon 20 mutant patients (43% objective response rate) but with several limitations including lower potency for mutations in the “far loop” region of exon 20 and toxicity due to inhibition of wild-type EGFR. In order to improve upon these limitations, this proposal we will investigate the structure- activity relationship of exon 18 and 20 EGFR inhibitors and use this information to develop inhibitors with greater potency and specificity for atypical mutants, thereby addressing a major unmet need for these patients.

PI_NAMEs: HEYMACH, JOHN V. (contact);JONES, PHILIP

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Acceleration;Address;Adverse event;Affinity;Binding;Cancer Patient;Classification;Clinical;Clinical Data;Crystallography;Data;design;Development;Diarrhea;Dose;Drug Kinetics;Drug resistance;Drug Screening;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;ERBB2 gene;Evaluable Disease;Exanthema;Exons;experience;FDA approved;Generations;Genetically Engineered Mouse;improved;in silico;In Vitro;in vivo;inhibitor;insight;interdisciplinary approach;Laboratory Scientists;Libraries;Malignant Neoplasms;Medicine;Modeling;Molecular;molecular dynamics;molecular modeling;multidisciplinary;mutant;Mutation;Nature;Non-Small-Cell Lung Carcinoma;novel;objective response rate;patient derived xenograft model;Patients;Pharmaceutical Chemistry;Pharmaceutical Preparations;phase II trial;Physicians;Population;pre-clinical;prevent;Progression-Free Survivals;rational design;receptor;Receptor Inhibition;Reporting;research clinical testing;Research Personnel;Resistance;Resources;response;Retrospective Studies;Specificity;Structural Biologist;Structure-Activity Relationship;Subgroup;Testing;Therapeutic Agents;Toxic effect;Translating;tumor;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Molecular features impacting drug resistance in atypical EGFR exon 18 and exon 20 mutant non-small cell lung cancers and the development of novel mutant-selective inhibitors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it will provide new insights into role of adipose tissue in the metabolic dysfunction associated with obesity and will evaluate the effectiveness of exercise in combatting obesity-associated adipose maladaptations. In addition, this study will provide new fundamental knowledge of how adipose tissue may contribute to the beneficial adaptations to exercise. This project is relevant to the mission of the NIDDK because it fulfills the critical need for understanding the factors that contribute to obesity-associated metabolic dysfunction and the mechanisms by which exercise may serve as a potential countermeasure to this dysfunction.

PI_NAMEs: KUNZ, HAWLEY E (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Abdomen;Acute;adipokines;Adipose tissue;adult obesity;Affect;Aging;Ancillary Study;Bioinformatics;Biology;Biopsy;career development;cell type;Cells;chemokine;Chronic;Clinic;Clinical Research;Clinical Trials;Communication;cytokine;Data;Data Collection;Development Plans;Diabetes Mellitus;Distal;Distant;Educational Intervention;effectiveness evaluation;Elderly;Elements;Endocrine;Event;Exercise;exercise training;experience;extracellular vesicles;Fatty acid glycerol esters;Fostering;Foundations;Functional disorder;Gene Expression;Goals;Health;Hormonal;Hour;Human;Immune;immune cell infiltrate;Immunohistochemistry;Immunophenotyping;improved;Individual;Inflammation;Inflammatory;insight;Interdisciplinary Study;Investigation;Knowledge;Laboratories;Lead;Learning;Leukocytes;Logistics;Macrophage;Mass Spectrum Analysis;Measurement;Measures;Mentors;Mentorship;Metabolic;Metabolic dysfunction;Mission;modifiable lifestyle factors;Molecular;Molecular Profiling;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Nutrient;Obesity;older adult;paracrine;Persons;Phenotype;Physiological;Physiology;Plasma;Play;Population;Positioning Attribute;Prediabetes syndrome;Productivity;programs;prospective;Proteomics;protocol development;Public Health;Publishing;Research;Research Personnel;response;Reverse Transcriptase Polymerase Chain Reaction;Role;Science;Scientist;Signal Transduction;skills;subcutaneous;supportive environment;T-Lymphocyte;Techniques;Tissue Sample;Tissues;Training;training opportunity;transcriptome sequencing;transcriptomics;Translational Research;Weight;Work

PROJECT_TITLE: The role of adipose tissue in adaptive responses to exercise

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Women's Health Research

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: PROJECT NARRATIVE This award supports the career development of Courtney J. Stevens, PhD, a clinical psychologist at Dartmouth-Hitchcock Medical Center whose long-term career goal is to become a leading investigator in behavioral oncology and health behavior intervention science. The training and mentoring plan is designed to provide knowledge and skills in early-phase intervention development, intensive longitudinal data collection and analysis methods, randomized clinical trial design, and professional development. The research component follows the Obesity-Related Behavioral Intervention Trials (ORBIT) Model in systematically developing an intervention that will be used in subsequent research to test the hypothesis that the affect-regulated exercise prescription can promote clinically meaningful increases in moderate-vigorous physical activity among physically inactive breast cancer survivors.

PI_NAMEs: STEVENS, COURTNEY JOYCE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Accelerometer;Address;Adherence;adherence rate;Adverse effects;Affect;Affective;Aftercare;American;arm;Arousal;Award;Behavior;Behavior Therapy;Behavioral;Breast Cancer Risk Factor;Breast Cancer survivor;Breast Cancer survivorship;cancer diagnosis;cancer recurrence;Cancer Survivor;Cancer Survivorship;career;career development;Clinical;Clinical Trials Design;college;Consultations;Data;Data Analyses;Data Collection;design;Development;Diagnosis;Doctor of Philosophy;Ecological momentary assessment;Exercise;exercise prescription;exercise regimen;Fatigue;Feeling;follow-up;General Population;Goals;Guidelines;Health behavior;Health Benefit;health related quality of life;hedonic;improved;Individual;innovation;Intervention;Intervention Trial;Investigation;K-Series Research Career Programs;Knowledge;Light;Longitudinal Studies;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical center;Mentors;method development;Methods;Modeling;modifiable risk;Modification;mortality;motivated behavior;novel strategies;Obesity;Oncology;Outcome;Participant;participant interview;patient oriented;Persons;Phase;Phase Ib Trial;Physical activity;physical conditioning;Physical Function;physical inactivity;pleasure;Positioning Attribute;post intervention;preference;Protocols documentation;Psychologist;Public Health;Randomized;randomized, clinical trials;Recommendation;Regulation;Research;Research Personnel;response;Risk Factors;Sampling;satisfaction;Science;Scientist;skills;Sports Medicine;standard of care;Strenuous Exercise;Structure;Surveys;Survivors;Testing;therapy development;Time;Training;Treatment-Related Cancer;Variant;Work

PROJECT_TITLE: Increasing physical activity among breast cancer survivors: Use of the ORBIT Model to refine and test a novel approach to exercise promotion based on affect-regulation

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative This research project is directed toward an understanding of how genes encoding cell surface molecules determine the structures of synaptic circuits in the brain. Although most of our work is conducted in Drosophila, many of the genes we are studying have human counterparts. We hope to reveal general principles that will illuminate the mechanisms by which human brain wiring is controlled before and after birth.

PI_NAMEs: OZKAN, ENGIN ;ZINN, KAI G (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Affinity;Area;Avidity;axon guidance;Binding;Birth;Brain;Cell Adhesion Molecules;cell assembly;Cell Communication;Cell surface;Cell Surface Proteins;Cells;connectome;Dendrites;Development;Disease;Drosophila genus;early screening;Family;Genes;Goals;Human;human disease;Immunoglobulins;improved;In Vitro;in vivo;Individual;insight;Interneurons;Invertebrates;Ligands;Mammals;Maps;Measures;Mediating;meter;Methods;Muscle;mutant;nanoparticle;nerve supply;Nervous System;nervous system development;neural circuit;neuromuscular system;neuron loss;Neurons;Neuropil;neuroregulation;neurotransmission;Optic Lobe;Outcome;Pattern;postsynaptic;presynaptic;Presynaptic Terminals;Probability;programs;Protein Tyrosine Phosphatase;Proteins;Publishing;receptor;Receptor Signaling;Research;Research Project Grants;Role;screening;Side;Signaling Molecule;Specific qualifier value;Structure;Sum;Surface Plasmon Resonance;Synapses;synaptogenesis;System;Variant;Visual;Work

PROJECT_TITLE: Control of neural circuit assembly by cell surface protein interactions

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Genetic Testing;Genetics;Health Services;Nanotechnology;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: KANSAS CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: RELEVANCE TO PUBLIC HEALTH Unlike breast, cervical, or colon cancer, there is no reliable screening test to detect ovarian cancer, which requires invasive surgery and removal of the ovaries in order to make a definitive diagnosis. Currently, neither CA125 nor transvaginal sonography alone yield adequate sensitivity or specificity for early detection and the U.S. Prevention Services Task Force does not recommend routine screening for ovarian cancer using any method. The proposed studies will develop new tools to detect epithelial ovarian cancer at earlier stages when existing therapies are curative and when potentially preventative.

PI_NAMEs: GODWIN, ANDREW K. (contact);ZENG, YONG

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: 3-Dimensional;Advanced Malignant Neoplasm;Advisory Committees;Area;Benign;Biological Assay;Biological Markers;Biology;biomarker panel;Biopsy;Blood;Blood capillaries;Blood specimen;Body Fluids;BRCA mutations;CA-125 Antigen;Cancer cell line;Cancer Control;Cancer Detection;cancer diagnosis;Cancer Diagnostics;Cancer Patient;candidate marker;candidate validation;Carcinoma in Situ;Cell Line;Circulation;Clinical;clinical diagnosis;Clinical Sensitivity;clinical translation;Colon Carcinoma;Communication;Companions;cost;curative treatments;Death Rate;Detection;detection assay;Development;Diagnosis;diagnostic platform;Diagnostic Sensitivity;Disease;disorder risk;Drops;early detection biomarkers;Early Diagnosis;effusion;Engineering;Epithelial ovarian cancer;Excision;exosome;extracellular vesicles;Fingerprint;General Population;Generations;Goals;high risk population;Human;imaging modality;Immune response;Immunoassay;Immunoprecipitation;innovation;Intervention;liquid biopsy;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Mass Spectrum Analysis;Messenger RNA;Methods;microchip;microfluidic technology;Microfluidics;MicroRNAs;microsystems;mortality;mutation carrier;nano;Nanochip Analytical Device;nanoengineering;nanomaterials;nanopattern;Neoplasm Circulating Cells;neoplastic cell;novel;novel marker;Operative Surgical Procedures;Outcome;Ovarian;Ovary;Pathway interactions;patient prognosis;Patients;Pattern;Plasma;Play;Population Control;pre-clinical;presymptomatic testing;prevention service;Printing;protein biomarkers;protein profiling;Proteins;Proteomics;Public Health;Reporting;Reproducibility;Risk;Role;routine screening;Sampling;screening;Screening for cancer;Screening for Ovarian Cancer;self assembly;Sensitivity and Specificity;Serous;Serum Markers;Signaling Protein;Solid Neoplasm;Source;Specificity;Specimen;Symptoms;Technology;Testing;Time;Tissues;tool;Training;treatment response;tumor;Tumor Antigens;Tumor Markers;tumor progression;Tumor stage;Tumor-Derived;Ultrasonography;Untranslated RNA;Vagina;Validation;Vesicle;Woman

PROJECT_TITLE: Extracellular Vesicle Proteomic Fingerprinting of Ovarian Cancer for Early Detection with a Nanoengineered Microsystem

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prostate Cancer;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: PROJECT NARRATIVE Current systematic prostate biopsies use a one-size-fits-all biopsy plan that is still being used even in conjunction with modern MRI-guided fusion biopsy devices, and the biopsy remains freehanded making the results variable among urologists. We have developed novel software that optimizes the biopsy plan for each patient and a robot that handles the ultrasound probe and automatically orients the needle-guide to follow the plan, making the biopsy procedure hands-free and independent of physician’s skills. We have successfully completed a safety and feasibility clinical trial, and propose a larger randomized clinical trial to investigate if our robot increases the detection rate of clinically significant prostate cancer relative to that of a modern commercial biopsy device.

PI_NAMEs: STOIANOVICI, DAN  (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 3D ultrasound;Adverse event;arm;Biopsy;Biopsy Specimen;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer type;Cessation of life;Clinical;Clinical Trials;clinically significant;Cognitive;Computer software;Core Biopsy;Detection;Devices;Diagnosis;Disease;Effectiveness;feasibility testing;Gland;Gleason Grade for Prostate Cancer;Hand;Image;Image Analysis;improved;Information Systems;Institutional Review Boards;Interventional Ultrasonography;Lesion;Location;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Marketing;men;Methods;Modernization;Needle biopsy procedure;Needles;novel;novel strategies;Pathology;patient subsets;Patients;Phase;Phase 0 Trial;Phase I Clinical Trials;Physicians;Play;primary outcome;Probability;Procedures;Prostate;prostate biopsy;Prostatectomy;Radical Prostatectomy;radiologist;randomized, clinical trials;Reporting;response;Risk;Robot;robot assistance;robot control;robotic device;Robotics;Role;safety and feasibility;safety testing;Sampling;Screening for Prostate Cancer;secondary outcome;Shapes;simulation;skills;Specificity;Staging;Technology;Three-Dimensional Image;Time;Training;Transrectal Ultrasound;trend;ultrasound;United States Food and Drug Administration;Urologist;Visual

PROJECT_TITLE: Robot-Assisted Personalized Prostate Biopsy

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Relevance to Public Health SIGNIFICANCE:  Cancer incidence and mortaility trends show therapeutic progress against multiple liquid and solid tumors, but some solid tumor types such as liver cancer remain exceptions [Siegel 2020], which motivates a deeper understanding of solid tumors.  We hypothesize a causal biophysical link between two aspects of solid tumors that are widely considered unrelated, namely (1) stiffness of the tissue which is a major risk factor for liver cancer – as it is for other maliganancies such as breast cancer, and (2) genetic changes – that are a hallmark of cancer and that are increasingly being targeted in therapy but are also most abundant in solid tumors.  We propose a mechano-genetics process in which genetic changes are caused by tissue stiffness including compression in mitosis, and to test our hypothesis and clarify aspects of mechanism, we will develop and apply a novel approach with gene editing that allows us to see genetic changes in real-time, in single cells under physical duress.

PI_NAMEs: DISCHER, DENNIS E. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: 3-Dimensional;Alleles;Biophysics;Biopsy;Brain;cancer cell;cancer imaging;cancer type;Cell Count;Cell division;cell killing;Cell Nucleus;Cell Separation;Cells;chromosome loss;chromosome missegregation;Chromosomes;constriction;Cytoplasm;Defect;DNA;DNA Damage;DNA Repair;DNA sequencing;Engineering;Engraftment;Exhibits;experimental study;Flow Cytometry;Genes;Genetic;Genetic Processes;Goals;Growth;Hematopoietic Neoplasms;Heritability;Human;human induced pluripotent stem cells;Image;Immune checkpoint inhibitor;Immunodeficient Mouse;In Vitro;in vivo;Incidence;Injections;Interphase;intraperitoneal;Karyotype determination procedure;knock-down;Link;Liquid substance;Liver;liver cancer patient;Liver neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant Neoplasms;Measures;Mechanics;Methods;micronucleus;Mitosis;Mitotic spindle;Modernization;Motility;Mutation;Normal Cell;novel strategies;Nuclear Envelope;Palpable;Pathway interactions;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Phenotype;Physics;Point Mutation;pressure;prevent;Process;Public Health;red fluorescent protein;Reporter;Risk Factors;Rupture;Shapes;Site;soft tissue;Soft Tissue Neoplasms;Solid Neoplasm;Sorting;spheroids;Squash;Stress;subcutaneous;Suspensions;Testing;Therapeutic;three dimensional cell culture;Three-Dimensional Imaging;Time;Tissues;trend;tumor;Tumor Suppressor Proteins;Tumor Tissue;tumor xenograft

PROJECT_TITLE: Live cell reporters of genetic changes in stiff vs soft surroundings - Causes & Consequences


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Lung;Precision Medicine;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE  Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal disease with marked individual disease heterogeneity as some patients progress rapidly while others have a disease course marked by periods of relative stability. The ability to distinguish what patients are most likely to progress quickly represents an urgent and unmet need for both IPF patient care and research. The purpose of this study is to use novel imaging techniques and molecular biomarkers of lung injury to assess IPF disease activity with the ultimate goal of developing the ability to predict disease progression.

PI_NAMEs: MONTESI, SYDNEY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Acceleration;Alveolar;antifibrotic treatment;biomarker development;biomarker discovery;biomarker validation;Blood Vessels;blood-brain tumor barrier;Capillary Permeability;career;career development;Clinical;clinical phenotype;Clinical Research;Clinical Trials;Clinical Trials Design;cohort;Cohort Studies;contrast enhanced;Critical Care;Data;Development;Development Plans;Diagnosis;Disease;disease heterogeneity;Disease Progression;Early identification;Endothelial Cells;Endothelium;Ephrin-B2;Evaluation;experience;feasibility trial;Fibrosis;General Hospitals;Goals;healthy volunteer;High Resolution Computed Tomography;high risk;idiopathic pulmonary fibrosis;Image;Image Enhancement;imaging biomarker;Imaging Techniques;improved;in vivo;indexing;Individual;individual patient;individualized medicine;Injury;instructor;Knowledge;Lung;lung imaging;lung injury;Lung Transplantation;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Mediator;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Molecular;molecular imaging;molecular marker;mortality;nintedanib;novel;novel imaging technique;Observational Study;Outcome;Patient Care;patient oriented research;Patients;Permeability;Physicians;Plasma;Positioning Attribute;Prognosis;prognostication;progression risk;Progressive Disease;prospective;Pulmonary Fibrosis;Pulmonary function tests;Research;Research Infrastructure;Resources;response;Risk;Scientist;Severity of illness;Signal Transduction;skill acquisition;Specialist;Stable Disease;Statistical Methods;Techniques;Testing;Time;tissue injury;Training;treatment planning;treatment response;tumor;Vascular Endothelial Growth Factors;Vascular Permeabilities;Vital capacity;X-Ray Computed Tomography

PROJECT_TITLE: Vascular Leak and Outcomes in IPF

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Genetics;Hearing Loss;Human Genome;Neurodegenerative;Neurosciences;Prevention;Rehabilitation;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: NARRATIVE The gradual loss of hearing is a common manifestation of aging, ultimately affecting communication and leading to social exclusion and cognitive decline. The genetics of age-related hearing loss is multifactorial, with more than 50 genetic variations being associated with this impairment. To dissect this complexity, in this project we will replicate one human genetic variant in a mouse model to better study its function, connection to other genes, and sensitivity to noise damage, which will allow us to understand how it leads to age-related hearing loss and how we can delay or prevent this condition.

PI_NAMEs: GRILLET, NICOLAS  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Address;Adult;Affect;age acceleration;Age Months;Age related pathologies;Aging;aging process;Alleles;Animals;Antibodies;Auditory;auditory pathway;Biochemistry;Biological Assay;Cell membrane;Cells;Co-Immunoprecipitations;Cochlea;Cochlear Implants;Communication;Complementary DNA;Complex;Data;deafness;Defect;Dementia;Development;Disease;Ear;Elderly;Environmental Impact;Environmental Risk Factor;Etiology;European;Exhibits;Exposure to;Future;gene conservation;Genes;Genetic;Genetic Epistasis;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genotype;Goals;Hair Cells;Hearing;Hearing Aids;hearing impairment;hearing restoration;hereditary hearing loss;Homeostasis;Human;Human Genetics;humanized mouse;Hybrids;Impaired cognition;Impairment;Knock-in;Knock-in Mouse;Labyrinth;Libraries;Link;Lipoxygenase;loss of function;Mammals;mechanotransduction;Modeling;Molecular;Molecular Genetics;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;neurosensory;next generation sequencing;Noise;normal hearing;old mice;Organelles;Pathogenicity;Pathway interactions;Phenotype;Population;Predisposition;Presbycusis;prevent;Process;programs;Proteins;Recovery;Recovery of Function;Reporting;Research;response;Sensory;Severities;social exclusion;sound;Temporary Threshold Shift;Testing;transcriptomics;Variant;Work;Yeasts

PROJECT_TITLE: Molecular genetics of human age-related hearing loss

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative Despite effective antiretroviral treatment, nearly half of HIV+ patients suffer from persistent mild neurocognitive disorder which is exacerbated by opioid use. HIV-transactivator of transcription (Tat) protein is persistently secreted by infected cells, impairing mitochondrial function, BDNF levels, and recapitulating several aspects of HIV infection and HAND. As Tat and opioids convergently activate pathways that impair mitochondrial function, which in turn impairs behavior, this basic science program aims to characterize morphine- and Tat-induced behavioral and molecular abnormalities related to mitochondrial function and BDNF, and to evaluate whether oral dimethylfumarate attenuates morphine- and Tat-induced mitochondrial, BDNF and behavioral deficits.

PI_NAMEs: KAUFMAN, MARC J;MCLAUGHLIN, JAY P. (contact);THANGAVEL, SAMIKKANNU

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Address;Affect;Animal Behavior;Animal Model;Animals;Antioxidants;antiretroviral therapy;Anxiety;Applied Research;Attenuated;Autopsy;Basic Science;Behavior;behavior test;Behavioral;behavioral impairment;Biogenesis;Brain;brain dysfunction;brain metabolism;Brain-Derived Neurotrophic Factor;brain-derived neurotrophic factor precursor;Cells;Cognition;Cognitive;comorbidity;Corpus striatum structure;Data;Development;Doxycycline;Epidemic;Exposure to;Extinction;flexibility;frontal lobe;Fumarates;Functional disorder;Future;Genetic Complementation Test;Genetic Transcription;Hand;Health;HIV;HIV anti-retroviral;HIV Infections;HIV therapy;Human;Impaired health;Impairment;improved;In Vitro;in vivo;Individual;innovation;inorganic phosphate;insight;Intervention;Knowledge;Learning;Macaca;Magnetic Resonance Spectroscopy;Memory;Mental Health;Mitochondria;Mitochondrial Proteins;Molecular Abnormality;Moods;Morphine;Morphine Dependence;Mus;nanoparticle;nanoparticle delivery;neurocognitive disorder;Neurons;NF-E2-related factor 2;NGFR Protein;novel;novel therapeutics;nrf1 protein;nuclear respiratory factor;object recognition;Opioid;opioid use;opioid use disorder;Oral;Outcome;overdose death;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Phosphocreatine;Phosphorus;physical conditioning;Play;preference;programs;protein expression;Proteins;psychostimulant;Reporting;Research Project Grants;Risk;Sampling;Self Administration;Severities;Signal Transduction;SIV;Structure;Substance abuse problem;synaptogenesis;tat Protein;Testing;theories;Trans-Activators;Transcription Coactivator;Transgenes;Transgenic Organisms;United States National Institutes of Health;Viral;Viral Proteins;Virus Replication;Vulnerable Populations;Western Blotting;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Impacts of morphine and HIV-Tat exposures and dimethylfumarate treatment on brain BDNF and mitochondrial and behavioral dysfunction.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE The proposed research will evaluate the effect on HIV viral suppression of expanding community ART delivery to individuals newly diagnosed with HIV through the Head StART intervention in refugee settlements in Uganda. We will use the RE-AIM implementation science framework to evaluate the Reach, Effectiveness, Adoption, Implementation, and Maintenance of Head StART across study sites, and conduct a cost and budget impact analysis of the intervention. The project is responsive to PA-20-144 aims of improving HIV treatment outcomes and its results will provide crucial evidence for policymakers regarding effective, feasible, and low-cost strategies to strengthen the HIV care cascade among refugees.

PI_NAMEs: O'LAUGHLIN, KELLI NICOLE (contact)

PROGRAM_OFFICER_NAME: GREENWOOD, GREGORY LOUIS

PROJECT_TERMS: Address;Adherence;Adoption;Affect;antiretroviral therapy;arm;barrier to care;budget impact;Caring;Cessation of life;Client;Clinic;Clinical;clinical care;Cluster randomized trial;Communities;community based care;contextual factors;cost;cost comparison;Data;Diagnosis;Diphosphates;Disclosure;Effectiveness;effectiveness evaluation;Eligibility Determination;Ensure;Evaluation;Exclusion;Face;Financial cost;Fostering;Fright;Goals;Head Start Program;Health;high risk;HIV;HIV diagnosis;implementation framework;implementation research;improved;incremental cost;Individual;innovation;Intervention;intervention cost;intervention delivery;Link;Location;Maintenance;markov model;member;Modeling;Morbidity - disease rate;Motion;Newly Diagnosed;novel;Outcome;Outcome Study;Participant;Perception;Persons;Pilot Projects;Policy Maker;Population;primary outcome;Public Health;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Refugees;Reporting;Research;Rural;secondary outcome;Services;Site;social;Social Network;social stigma;Social support;standard care;standard of care;Stress;Tenofovir;Testing;therapy adherence;Time;Transportation;Travel;Treatment outcome;Uganda;United States National Institutes of Health;Variant;Viral;Viral Load result;Weather

PROJECT_TITLE: Achieving HIV viral suppression in refugee settlements in Uganda with Head StART: a cluster randomized trial evaluating the effectiveness of community ART delivery for people newly diagnosed with HIV

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Physical Activity

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Mitochondria, the powerhouse of heart cells, could send signals to nucleus to promote energy producing genes expression to further boost the powerhouse. The proposed study is to investigate how GCN5L1, an enzyme to regulate mitochondrial proteins activity through adding chemical modification, sends signals to nucleus to turn on energy producing genes expression. Understanding the process will potentially provide novel therapeutic targets for heart failure, a leading cause of death and hospital admission in United States.

PI_NAMEs: ZHANG, MANLING  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;Acetyltransferase;Amino Acids;aorta constriction;ATF2 gene;Attenuated;Award;Bioenergetics;Biogenesis;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cause of Death;Cell Nucleus;Chemicals;ChIP-seq;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Communication;cost;Data;Development;Down-Regulation;endurance exercise;Enzymes;Epigenetic Process;Exercise;Expression Profiling;fatty acid oxidation;Gene Expression;gene repression;Genes;Genetic;Genetic Transcription;genome editing;Goals;Hand;Heart;heart cell;Heart failure;heart metabolism;hepatic gluconeogenesis;Histone Acetylation;Hospitalization;Human;Impairment;improved;induced pluripotent stem cell;interest;knock-down;Knockout Mice;Learning Skill;Lysine;MAP Kinase Gene;Mediating;Mediator;Mentors;Metabolic;Metabolism;Mitochondria;Mitochondrial Proteins;Modification;Molecular;mortality;mouse model;Mus;myocyte-specific enhancer-binding factor 2;Neonatal;new therapeutic target;novel;Nuclear;overexpression;Oxidative Phosphorylation;p38 Mitogen Activated Protein Kinase;Pathologic;Peptides;Phosphorylation;Physicians;Play;Positioning Attribute;Post-Translational Protein Processing;PPAR gamma;Preparation;pressure;Prevalence;Process;programs;Proteins;Public Health;Rattus;Regulation;Research;response;Role;Scientist;Signal Transduction;Small Interfering RNA;Stress;Technology;Testing;therapeutic target;Tissues;tool;Transcription Coactivator;transcription factor;United States;Up-Regulation;Work

PROJECT_TITLE: The Role of GCN5L1 Mediated Mitochondria to Nucleus Retrograde Cardiac Metabolism Reprogramming in Exercise and Heart Failure

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative PUBLIC HEALTH RELEVANCE: Over 25 million people per year are treated emergently for injuries and more than 5 million people are admitted annually for critical illness. This Interdisciplinary Training in Injury and Critical Illness will help contribute to the next generation of trauma surgeon-scientists who can tackle the basic, translational, and clinical aspects of research spanning the bench to bedside. This research will center on the broad-expertise of our 16 faculty across 6 Departments at Vanderbilt covering the domains of 1) Injury and 2) Critical Illness.

PI_NAMEs: PATEL, MAYUR B (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Critical Illness;Injury;Training


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE  Heart failure affects 6.5 million individuals in the US and recent cardiovascular outcome trials (CVOTs) have demonstrated that SGLT2 inhibitors reduce hospitalization for heart failure (HHF) and cardiovascular mortality. SGLT2 inhibitors consistently increase the plasma ketone concentration and ketones are avidly taken up and metabolized by muscle to generate ATP. In the present grant we will examine the effect of exogenous ketone infusion, as well as the SGLT2i-induced rise in plasma ketone concentration, on skeletal and cardiac metabolism and on myocardial function and blood flow.

PI_NAMEs: DEFRONZO, RALPH A (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: acipimox;Affect;beta-Hydroxybutyrate;Blood flow;Butyrates;cardiac magnetic resonance imaging;Cardiovascular system;Deoxyglucose;design;Diabetes Mellitus;diabetic patient;Disease;Fatty Acids;Glucose;glucose uptake;Grant;Heart;Heart failure;heart failure with reduced ejection fraction;heart metabolism;Hospitalization;Individual;Infusion procedures;inhibitor;inhibitor therapy;Ketones;Left;Lipolysis;Metabolic;mortality;Muscle;muscle metabolism;Myocardial;Myocardium;New York;Outcome;Oxygen;Pharmaceutical Preparations;pharmacologic;Physiological;Placebos;Plasma;Positron-Emission Tomography;Protocols documentation;Risk;skeletal;Skeletal Muscle;Type 2 diabetic;uptake;Ventricular;Water

PROJECT_TITLE: Ketones, Muscle Metabolism, and SGLT2 Inhibitors

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Physical Activity;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Chronic pain is common among individuals treated with opioid agonist therapies (OAT; buprenorphine or methadone) and is associated with poorer opioid use disorder (OUD) outcomes, including higher attrition and higher levels of other drug use. The goal of this project is to develop and pilot test an integrated, web-based cognitive behavioral approach (R61 phase), and then conduct a randomized clinical trial evaluating its efficacy relative to standard care in a large and diverse sample of individuals with chronic pain treated with buprenorphine or methadone (R33 phase).

PI_NAMEs: HEAPY, ALICIA  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Abstinence;acceptability and feasibility;Acute;Address;Adherence;Affect;Agonist;Back;Behavior Therapy;Behavioral;Behavioral Research;Buprenorphine;chronic pain;chronic pain management;Cognitive;Cognitive Therapy;comorbidity;Complex;Coping Skills;cost;craving;Data;Development;Drug usage;E-learning;Education;Educational process of instructing;efficacy evaluation;Enrollment;Exercise;experience;Exploratory/Developmental Grants Phase II;feasibility testing;Feedback;follow-up;Frequencies;Goals;Grain;health care service;Helping to End Addiction Long-term;improved;Individual;Intervention;Measures;Medical;medication-assisted treatment;Mental disorders;Methadone;Monitor;Nature;Online Systems;Opioid;Opioid agonist;opioid agonist therapy;opioid epidemic;opioid use disorder;Outcome;Pain;Pain intensity;Pain interference;pain outcome;Pain Threshold;Patients;Phase;Physical activity;pilot test;Population;primary endpoint;programs;Provider;Public Health;randomized, clinical trials;response;Sampling;satisfaction;secondary outcome;Self Efficacy;Self Management;self-management program;skills;Sleep Disorders;sleep quality;social interventions;standard care;Standardization;Substance Use Disorder;Technology;Testing;therapy adherence;timeline;Toxicology;treatment as usual;Urine;Variant;Videotape;web-based intervention

PROJECT_TITLE: Adapting Web-based CBT to improve adherence and outcome for individuals with opioid use disorder and chronic pain treated with opioid agonists

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project will study a novel mouse model of ataxia. Given the severe ataxia seen in the model and the novel genetic findings, this project holds the potential to elucidate new understanding of the mechanisms that underlie ataxia.

PI_NAMEs: TELENSON, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Alleles;Animal Model;Animal Sources;Ataxia;autosome;Backcrossings;Bioinformatics;Biological Process;Brain Stem;Breeding;Candidate Disease Gene;causal variant;cell type;Cells;Central Nervous System;Cerebellum;Cessation of life;Chromosome Mapping;Computer Analysis;Critical Pathways;Data;Defect;design;Development;differential expression;Disease;Embryonic Development;Ensure;Equilibrium;Essential Genes;Exclusion;experimental study;extend lifespan;Fluorescent in Situ Hybridization;Gene Expression;Generations;Genes;Genetic;genetic approach;Genetic Complementation Test;genetic variant;Genetic Variation;Genome;genome analysis;genome sequencing;Genotype;Goals;Growth;Heterozygote;Human;human disease;Inherited;insight;life span;Light;Missense Mutation;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;neurodevelopment;Neurologic;neuromuscular;neuropathology;Nonsense Mutation;novel;Nutritional;Pathology;Pattern;Phenotype;postnatal;postnatal development;postnatal period;Principal Investigator;Probability;Process;segregation;Severities;skills;Slice;Spinal Ganglia;Stains;success;therapeutic development;Time;Tissues;Training;transcriptome sequencing;transcriptomics;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: Characterization of a Novel Ataxia Phenotype


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This application seeks funding to implement the enhanced Interdisciplinary Research Training Institute (eIRTI) that seeks to promote the career development of underrepresented pre-doctoral, postdoctoral and early career Hispanic scientists in drug and alcohol abuse and addiction research. Hispanics face unique health challenges and efforts to increase the number of well-qualified researchers prepared to conduct biomedical, behavioral and clinical research are vital to reducing health disparities among this underserved population. The complex and technical nature of contemporary substance abuse research and the growing demands for addiction-related knowledge across disciplines requires that competitive investigators develop a broad-based set of scientific knowledge and scientific research skills that will strengthen the NIH research pipeline.

PI_NAMEs: VALDEZ, AVELARDO  (contact)

PROGRAM_OFFICER_NAME: HOLMES, ANGELA L

PROJECT_TERMS: addiction;Address;Affect;African American;Alcohol abuse;alcohol research;Behavioral;Behavioral Research;Benchmarking;Biomedical Research;career;career development;Career Mobility;Clinical;Clinical Research;Communication;Competence;Complex;Development;Discipline;Dissemination and Implementation;Drug abuse;education research;Educational workshop;Ensure;Environment;environmental enrichment for laboratory animals;experience;Extramural Activities;Face;faculty mentor;Funding;Goals;Health;health disparity;Hispanic;Hispanic Populations;improve minority health;improved;Incubators;innovation;Institution;Interdisciplinary Study;interest;Knowledge;Leadership;Mediation;meetings;Mentors;Mentorship;minority health;minority health disparity;Minority Health Research;Nature;next generation;Not Hispanic or Latino;organizational structure;Outcome;Participant;peer;peer coaching;peer networks;Pharmaceutical Preparations;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;Prevention;Process;programs;psychosocial development;Publications;Qualifying;Reduce health disparities;Request for Applications;Research;Research Personnel;Research Training;Role;Scientist;Self Efficacy;senior faculty;skills;Structure;Substance abuse problem;Substance Addiction;substance use;Substance Use Disorder;substance use treatment;success;summer research;symposium;Technology;theories;Training;Training and Education;training opportunity;Training Programs;Translations;Travel;Underrepresented Populations;Underserved Population;United States National Institutes of Health;Work

PROJECT_TITLE: Enhanced Interdisciplinary Research Training Institute


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Chronic Pain;Clinical Research;Disability Research;Neurosciences;Pain Research;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SAN MARCOS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: CALIFORNIA STATE UNIVERSITY SAN MARCOS

PHR: Project Narrative Backpack loads can compress nerves and blood vessels leading to potential loss of hand function in military and first-responder personnel who may need immediate use of the hands. The proposed project will examine the acute physiological changes and functional deficits resulting from heavy backpack carriage to aid development of field-based functional measures to prevent upper limb disability.

PI_NAMEs: SCHMIDT, DEANNA J (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acute;Address;Affect;afferent nerve;arm;Biomechanics;Blood flow;Blood Vessels;Body Water;Body Weight;Brachial plexus structure;Chronic;constriction;Data;Development;dexterity;disability;Early Diagnosis;Edema;Esthesia;experimental study;Fingers;first responder;Goals;Hand;Hand functions;hand rehabilitation;Hand Strength;Health;Human Resources;Impairment;improved;Incidence;Individual;Injury;injury prevention;innovation;Law Enforcement;Light;Literature;loss of function;Lower Extremity;Manuals;Measurable;Measurement;Measures;Methodology;Military Personnel;Motor;Muscle Weakness;Muscular Atrophy;Nerve compression syndrome;Nerve Plexus;Neural Conduction;neuromuscular;Occupational;Pain;Paralysed;Performance;Persons;Physiological;Physiology;prevent;Prevention;Recreation;Reporting;Research;Research Design;response;Risk Reduction;Sensory Thresholds;Series;Shoulder;Symptoms;Testing;Time;Touch sensation;Upper Extremity;Vertebral column;Walking;Work

PROJECT_TITLE: Effect of Heavy Backpack Load Carriage on Acute Blood Flow, Nerve Conduction, Biomechanics and Dexterity of the Upper Limbs


NIH_SPENDING_CATS: Genetics

ORG_CITY: Columbus

ORG_DEPT: GENETICS

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative RNA surveillance pathways suppress genetic errors and also regulate normal gene expression to serve essential functions in eukaryotic cells. This work will define functions of the essential and non-essential components of the vertebrate RNA surveillance apparatus and investigate why mutations in these ubiquitous machineries lead to defects in neuronal and muscular tissues. The knowledge gained will be key to understand human diseases such as autism and intellectual disability and to devise new therapies.

PI_NAMEs: SINGH, GURAMRIT  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Adaptor Signaling Protein;Animals;Anti-viral Response;autism spectrum disorder;Binding;Biochemical;Cell Maintenance;Cell Physiology;Cell Survival;Cells;Complex;Defect;Development;Embryo;Eukaryota;Eukaryotic Cell;Exons;fitness;Gene Expression;Genetic;Genetic Processes;Genomics;Germ Cells;Goals;Health;Human;human disease;in vivo;Intellectual functioning disability;Knowledge;Lead;Location;Mediating;Mental Retardation;Messenger RNA;Modeling;Molecular;motor neuron development;mRNA Decay;mRNA Surveillance;Muscle;Muscle Development;mutant;Mutation;neurogenesis;Neurons;Nonsense Mutation;novel therapeutics;Organism;paralogous gene;Pathway interactions;Post-Transcriptional Regulation;posttranscriptional;premature;Process;programs;Proteins;Recycling;Regulation;Research;Ribosomes;RNA;Role;Shapes;Signal Transduction;Site;stem cells;Technology;Therapeutic;Tissues;Translations;Variant;Work;Zebrafish

PROJECT_TITLE: Post-transcriptional gene regulation by the exon junction complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Neurosciences;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Substance Misuse

PHR: PROJECT NARRATIVE The brain is an especially sensitive target for a variety of insults. New organoid culture technology allows for these insults to be studied separately and together to understand their impact on cell function for the different cell types in the brain. HIV-1, with its associated inflammation and treatment, opioids, and amyloid fibril disease are all interesting, especially in our aging population. Important aspects of their intersection on brain cell functions can now be studied.

PI_NAMEs: JOSEPH, SARAH BETH;SWANSTROM, RONALD I (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Affect;aging population;Amyloid deposition;Amyloid Fibrils;Astrocytes;Autopsy;Biological Assay;Biological Models;Blood;Brain;brain cell;brain tissue;CD4 Positive T Lymphocytes;Cell Culture Techniques;Cell Line;Cell Lineage;Cell Physiology;cell type;Cells;Central Nervous System Infections;Collaborations;comorbidity;density;Development;Disease;Environment;Epidemic;Evolution;Exposure to;fentanyl use;Frequencies;Future;Gene Expression;Gene Expression Profile;Genetic Transcription;HIV;HIV Infections;HIV-1;Human;human tissue;immunodeficiency;Individual;induced pluripotent stem cell;Infection;Inflammation;Inflammatory;Inflammatory Response;interdisciplinary approach;Interferons;Laboratories;Learning;Macrophage;Methadone;Microglia;Microscopy;Modeling;Morphology;National Institute of Allergy and Infectious Disease;neuroAIDS;Neurocognitive Deficit;neuron loss;Neurons;normal aging;Normal Cell;novel;Opioid;opioid exposure;opioid use;Opportunistic Infections;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Penetration;Persons;phenotypic biomarker;Predisposition;Process;Quality of life;Sampling;Science;single-cell RNA sequencing;Technology;Testing;Therapeutic;transcriptome sequencing;Virus;Virus Latency;Whole Organism;Work

PROJECT_TITLE: Intersection of HIV, Opiods, and Amyloid Fibrils in a CNS Organoid Model


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: NARRATIVE The Columbia University Digestive and Liver Disease Research Center seeks to combine innovative research concepts in its Biomedical Cores with outstanding clinical expertise, a large collection of biospecimens and a strong base of productive investigators to understand the causes and develop new treatment approaches for diseases of the digestive tract and liver, that are a major cause of morbidity and mortality.

PI_NAMEs: SCHWABE, ROBERT F. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Appointment;Automobile Driving;base;Basic Science;bioimaging;Bioinformatics;Biology;Cell Communication;Cells;Clinical;clinical application;Clinical Research;clinical translation;clinically relevant;Collaborations;Collection;Communities;Core Facility;Creativeness;Data;Databases;Detection;Digestive System Disorders;Direct Costs;Discipline;Disease;diversity and equity;Education;Educational workshop;Effectiveness;empowerment;Ensure;Environment;Epithelial Cells;Epithelium;equity, diversity, and inclusion;Esophagus;Evolution;forging;Functional disorder;Funding;Future;gastrointestinal;Goals;Grant;Growth;Homeostasis;Hospitals;improved;Inflammation;innovation;Institution;inter-institutional;Joints;Link;Liver;Liver diseases;Measures;member;Mentors;Metabolism;Mission;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Neoplasms;New York;next generation;novel therapeutic intervention;Organ;Organoids;Pancreas;Pathway interactions;patient population;Patients;Physiology;Presbyterian Church;Prevention;Productivity;programs;Publications;Research;Research Methodology;Research Personnel;Science;Scientist;Services;single cell analysis;Structure;success;symposium;therapeutic target;Training;Training and Education;Translations;United States National Institutes of Health;Universities;Vision


PROJECT_TERMS: Administrative Efficiency;Administrator;Adult;base;Basic Science;bioimaging;Bioinformatics;Biology;biomedical resource;career development;Caring;Cell Culture Techniques;Cells;Childhood;Clinical;Clinical Research;Collaborations;Communication;Communities;community engagement;Community Outreach;Dedications;Digestive System Disorders;Disease;Doctor of Philosophy;Education;Educational Activities;Educational workshop;Effectiveness;empowerment;Ensure;Environment;Epithelial Cells;Epithelium;equity, diversity, and inclusion;Evaluation;Evolution;Expenditure;experience;Feedback;Fees;Fostering;Funding;Future;Grant;Growth;Health;Homeostasis;Image;Inflammation;innovation;Institution;interest;Leadership;life span;Link;Liver diseases;member;Mentors;Mentorship;Metabolism;Mission;Monitor;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;Natural regeneration;Neoplasms;new technology;next generation;operation;Organ;Organoids;Productivity;programs;Publications;Recording of previous events;Research;research and development;Research Personnel;Research Support;Resources;Schools;Science;Scientist;Services;single cell analysis;social media;Structure;success;Surveys;Technology;Training;Translational Research;Universities;Vision;web site;Work

PROJECT_TITLE: The Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Genetics;Human Genome;Physical Activity;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Understanding how exercise has its salutary effects on human health is a laudable goal in itself. However, the real benefits accrue from this knowledge when we understand how to tailor exercise to an individual’s specific health needs; and how we can use this knowledge to develop new pharmacologic therapies unimagined before this knowledge was revealed. Making significant advances along this path is the goal of this project

PI_NAMEs: KRAUS, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: SHIROMA, ERIC JITSUO

PROJECT_TERMS: Address;Adopted;Advisory Committees;Aerobic;American;Area;Automobile Driving;biobank;Bioinformatics;Biological;Biology;Blood;blood glucose regulation;Body Composition;cardiometabolic risk;cardiometabolism;cardiorespiratory fitness;causal model;Characteristics;Chromatin;Chronic;Clinical;Clinical Data;cohort;Complex;Data;Data Discovery;Data Set;Databases;demethylation;Development;DNA;DNA Methylation;Drug Targeting;Epigenetic Process;epigenetic profiling;epigenome;Evaluation;Exercise;exercise program;exercise training;Exposure to;functional genomics;Gene Expression;Generations;Genes;Genome;Goals;Guidelines;Health;Health Benefit;health goals;Hour;Human;improved;In Vitro;Individual;innovation;insight;Insulin;insulin signaling;interest;Kinetics;Knowledge;Life Style;Lipids;Lipoproteins;Literature;Maintenance;Maps;Mediating;Mediation;Mediator;Medicine;Metabolic;Metabolic syndrome;Metabolism;metabolome;metabolomics;Methods;Methylation;methylome;microphysiology system;Modality;Modeling;Modification;Molecular;molecular drug target;Molecular Target;Muscle;novel therapeutics;Organ;organ on a chip;Outcome;Pathway interactions;pharmacologic;Physical activity;Physical Fitness;Physiological;Physiology;Process;programs;protein expression;Proteome;Proteomics;Regimen;Regulatory Pathway;Reporting;Resistance;Resources;response;Sampling;Science;Scientist;Signal Pathway;Signal Transduction;skeletal;Skeletal Muscle;System;Talents;Testing;Time;Training;Training Programs;transcriptome;transcriptomics;Work

PROJECT_TITLE: Skeletal Muscle Molecular Drug Targets for Exercise-induced Cardiometabolic Health

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative: The proposed research will increase our understanding of the basic mechanisms that promote and ensure the faithful inheritance of chromosomes. The work is highly relevant to human health, as errors in chromosome inheritance are one of the leading causes of miscarriages and birth defects and are also a major factor contributing to the development and progression of cancer. Some aspects of our program will address how repair of DNA breaks is organized and regulated, which is important for maintaining intact chromosomes and for inheriting the correct number of chromosomes. Other aspects will address the physical organization of chromosomes, the spatial relationships between chromosomes, how key events are coordinated during the meiotic program, and how these features contribute to successful inheritance of genomes.

PI_NAMEs: VILLENEUVE, ANNE M (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;Area;Biochemical;Caenorhabditis;Caenorhabditis elegans;Cells;Chromosome Pairing;Chromosome Structures;Chromosomes;Congenital Abnormality;Cytology;Development;Diploidy;Distant;DNA Double Strand Break;DNA Repair;Ensure;Equilibrium;Event;Failure;Genetic;Genetic Crossing Over;Genome;genome integrity;Genomics;Germ Cells;Goals;Haploidy;Health;Homologous Gene;Human;Hybrids;Investigation;Meiosis;Meiotic Recombination;Modeling;Molecular;Nematoda;novel strategies;Organism;Positioning Attribute;Preparation;Process;programs;Property;Prophase;repaired;Research;segregation;spatial relationship;Spontaneous abortion;success;System;tumor progression;Work

PROJECT_TITLE: Meiotic Chromosome Inheritance in Caenorhabditis

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Liver Disease

PI_NAMEs: ABRAMS, JULIAN  (contact)

PROJECT_TERMS: Agreement;Area;Basic Science;biobank;bioimaging;Bioinformatics;Biometry;Cancer Center;Cell Culture Techniques;Cell Nucleus;Cells;Clinical;Clinical Data;Clinical effectiveness;Clinical Investigator;Clinical Research;Collaborations;Collection;Consultations;cost effective;Data;Data Element;data integration;data management;Databases;Digestive System Disorders;Disease;Education;Educational workshop;Electronic Health Record;empowerment;Ensure;Epithelial Cells;Feedback;Fertilization;Freezing;Funding;Goals;histopathological examination;Homeostasis;Human;human subject;Human Subject Research;Image;Immunologic Monitoring;Infrastructure;innovation;Institution;Interdisciplinary Study;interest;Leadership;life span;Link;Liver diseases;meetings;member;Mission;Modeling;next generation;novel;operation;Organ;Organizational Efficiency;Organoids;patient population;Patient Selection;Patients;prevent;programs;Qualifying;Quality Control;Records;repository;Research;Research Design;Research Personnel;Research Support;Research Training;Resources;RNA;Sampling;Science;Scientist;Services;single cell analysis;single nucleus RNA-sequencing;Specimen;Structure;Surveys;symposium;Tissue Microarray;Tissues;Training;Translational Research;translational study;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: The Clinical Biospecimen and Research Core


NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Genetics;Human Genome;Liver Disease

PI_NAMEs: SIMS, PETER ALAN (contact)

PROJECT_TERMS: Adult;biobank;bioimaging;Bioinformatics;Biological Process;Biology;Cell Communication;Cell Culture Techniques;Cell Nucleus;Cells;Childhood;Clinical;Collaborations;Complex;cost effective;CRISPR screen;Custom;Data;Data Set;Development;Diagnosis;Digestive System Disorders;Dimensions;Disease;Disease Progression;Drug Screening;Education;Educational workshop;empowerment;Ensure;Epithelium;Experimental Designs;FarGo;Feedback;Functional disorder;Gastrointestinal tract structure;gene regulatory network;Genetic Transcription;Health;Homeostasis;Human;human data;Individual;innovation;innovative technologies;insight;Interdisciplinary Study;interest;Leadership;Ligands;Link;Liver diseases;Mediating;Medicine;member;mid-career faculty;Mission;Mus;new therapeutic target;novel;operation;Organ;Organizational Efficiency;Organoids;Pathway Analysis;Patients;Process;professor;programs;public database;Qualifying;Quality Control;receptor;Records;Research;Research Personnel;Resources;Sampling;Scientist;Services;single cell analysis;single cell ATAC-seq;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;Surveys;Systems Biology;Therapeutic Intervention;Time;Tissue-Specific Gene Expression;Training;Training and Education;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translational Research;Universities

PROJECT_TITLE: The Bioinformatics and Single Cell Analysis Core


ORG_CITY: EUGENE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Narrative In this work, we are studying the cellular machinery that controls actin polymerization. Bacteria and viruses use this machinery to infect human cells and cancerous cells depend on it to spread. Therefore, improving our understanding of the molecules that constitute this machinery will contribute to our understanding of diseased states in humans and how to treat them.

PI_NAMEs: NOLEN, BRADLEY J (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TITLE: Control of actin filament networks by Arp2/3 complex and its regulators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: We have discovered novel non-image forming vision mechanisms in flies and mosquitoes that control light avoidance/attraction behavioral responses and other light evoked behaviors. Using a combination of physiological and behavioral approaches combined with molecular genetics and precision programmable custom designed LED light devices, we will determine how non-imaging forming and image forming visual mechanisms coordinate to control insect light responses in a species specific fashion. This research will lead to more effective light based devices for species-specific harmful insect control to combat vector-borne human diseases.

PI_NAMEs: HOLMES, TODD C (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TITLE: UV to blue neuronal phototransduction mechanisms


PI_NAMEs: NAKAGAWA, HIROSHI  (contact)

PROJECT_TERMS: 3-Dimensional;Adult;bioimaging;Bioinformatics;Biological Models;Catalogs;Cell Communication;Cell Culture System;Cell Culture Techniques;Cell Line;cell repository;Cells;Childhood;Clinical;Coculture Techniques;Collaborations;Communities;Consult;cost effective;cost effective measures;cost effectiveness;CRISPR screen;CRISPR/Cas technology;Cryopreservation;Data;Development;Digestive System Disorders;Disease;disease model;Doctor of Philosophy;Drug Screening;drug testing;Education;Educational workshop;Emerging Technologies;Epithelial Cells;Equipment;Experimental Designs;experimental study;expression vector;Feedback;gastrointestinal;Gene Expression;Genes;genetically modified cells;Genome;Grant;Growth;Guide RNA;Hepatobiliary;high resolution imaging;Homeostasis;Human;Human Cell Line;Human Resources;induced pluripotent stem cell;Internet;Laboratories;Leadership;Lentivirus Vector;Libraries;life span;Link;Liver diseases;Measures;Mediating;Medicine;member;Mission;Modeling;Molecular;Morphology;Mouse Cell Line;Mus;Mycoplasma;Mycoplasma Infections;new technology;novel;operation;Organoids;Pancreas;Pancreatic Diseases;Patients;pediatric patients;pre-clinical;programs;Protocols documentation;Quality Control;Reagent;repository;Reproducibility;Research;Research Personnel;RNA Interference;Science;Scientist;Series;Services;single cell analysis;spheroids;Standardization;Surveys;System;Techniques;Technology;Testing;Tissues;tool;Training;Training and Education;transcriptome sequencing;Transgenic Mice;Translational Research;Translations;Universities;Visualization;Work

PROJECT_TITLE: The Organoid and Cell Culture Core


ORG_CITY: DALLAS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: NARRATIVE The goal of the UT Southwestern Integrative Immunology Training Program (IITP) is to prepare graduate students, medical scientist trainees, and post-doctoral fellows for cutting-edge careers in immunology and related fields. The IITP leverages the outstanding educational and research environment at UT Southwestern Medical Center to provide an understanding of the basic, public health, and clinical problems related to immunology, and to foster the intellectual, technical, and communication skills required to succeed in the biomedical workforce. Such training is essential for resolving pressing global health issues such as emerging infectious diseases and an aging population suffering from metabolic and autoimmune diseases.

PI_NAMEs: HOOPER, LORA V (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Grant;Immunology;Training

PROJECT_TITLE: Integrative Immunology Training Grant

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Digestive Diseases;Liver Disease

PI_NAMEs: OLIVE, KENNETH P. (contact)

PROJECT_TERMS: 3-Dimensional;animal imaging;Animals;Basic Science;bioimaging;Bioinformatics;Biology;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;Cellular Structures;Chemistry;Clinical;clinical imaging;Collaborations;Complex;cost;Data;Development;Digestive Physiology;Digestive System Disorders;Disease;Doctor of Philosophy;Education;Educational workshop;Emerging Technologies;Engineering;Ensure;Epithelial Cells;Epithelium;Evaluation;experience;Feedback;Fees;Fibroblasts;Fibrosis;Fluorescence;fluorescence imaging;Fluorescence Microscopy;Funding;Future;Gastrointestinal Motility;Goals;Health;Herbert Irving Comprehensive Cancer Center;high resolution imaging;Histology;Homeostasis;Human;human imaging;Human Resources;Image;imaging capabilities;Imaging Device;imaging modality;imaging platform;Imaging technology;Immune;In Vitro;in vivo;in vivo imaging;Individual;Inflammation;innovation;innovative technologies;instrumentation;Intervention;Laboratories;Leadership;Link;Lipids;Liver diseases;Magnetic Resonance Imaging;mass spectrometric imaging;Measurement;member;Microbe;microbiota;microCT;Microscope;Microscopy;Mission;Motility;multi-photon;multimodal data;multiple datasets;Mus;nanometer;Natural regeneration;Neoplasms;Nerve;new technology;novel;Olives - dietary;operation;optical imaging;Optics;Organ;Organizational Efficiency;Organoids;patient derived xenograft model;Peptides;Pharmaceutical Preparations;programs;Proteins;Protocols documentation;Qualifying;Quality Control;reflectance confocal microscopy;Research;Research Personnel;Research Support;Resolution;Resource Sharing;Resources;response;Science;Scientist;Services;Signal Pathway;single cell analysis;single-cell RNA sequencing;Specimen;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;success;superresolution microscopy;Surveys;Technology;technology platform;Time;Tissues;tool;Training;Training and Education;transcriptomics;ultra high resolution;ultrasound;United States National Institutes of Health;Universities;X-Ray Computed Tomography

PROJECT_TITLE: The Bioimaging Core