NIH_SPENDING_CATS: Clinical Research;Health Services;Patient Safety

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Teams of clinicians (physicians, nurses, physical therapists, etc.) provide care for the sickest patients in the hospital in intensive care units, but there is little consistency nationwide about who should be part of the team caring for these patients or how many patients an individual physician, nurse, or other ICU clinician can safely care for. Using survey data coupled with existing data on patients in intensive care units (ICUs), this study will describe current staffing patterns in ICUs in the US, identify the best team structures, and make workforce projections through 2050 to achieve optimal patient outcomes. This study has large public health implications as the demand for intensive care is expected to increase with an aging population; this study’s findings will aid in resource planning and policy initiatives to ensure patient safety.

PI_NAMEs: GERSHENGORN, HAYLEY BETH (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Acute respiratory failure;Address;Administrator;Admission activity;Adult;Affect;Age Distribution;aging population;American;asthma exacerbation;Beds;California;care coordination;care delivery;care providers;Caring;Case Mixes;Censuses;Certification;clinical database;Clinical Pharmacists;cohort;Complex;Country;Coupled;Critical Care;Critical Illness;Data;Dedications;Destinations;Discipline of Nursing;dynamic system;Ensure;Environment;evidence base;functional status;Future;Goals;health care quality;Healthcare;Hospital Mortality;Hospitals;improved;improved outcome;individual patient;insight;Intensive Care;Intensive Care Units;Knowledge;Laws;Length of Stay;Life;Light;Link;Lung Diseases;Masks;Massachusetts;Mechanical ventilation;Medicine;member;Methodology;Modeling;mortality;multidisciplinary;novel;Nurses;Online Systems;Organization administrative structures;Outcome;Oxygen;Patient Care;Patient Care Team;patient safety;Patient-Focused Outcomes;Patients;Pattern;Pharmacists;physical therapist;Physicians;Policies;Policy Maker;Population Growth;pressure;Professional Organizations;Provider;Public Health;Pulmonology;Quality of Care;Recommendation;Resources;respiratory;Respondent;response;Sampling;Services;Severities;Severity of illness;Societies;Structure;Surveys;System;Training;United Kingdom;United States;Update;ventilation;Work;workforce needs;Workload

PROJECT_TITLE: Optimizing Intensive Care Unit Staffing in the United States


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: NEW HAVEN

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: NATHANSON, MICHAEL H (contact)

PROJECT_TERMS: 3-Dimensional;Award;Awareness;Brightfield Microscopy;cellular imaging;Complement;confocal imaging;Confocal Microscopy;Core Facility;cost;Cryoultramicrotomy;Data Analyses;design;Disease;Electron Microscopy;Electrons;Ensure;Equipment;equipment acquisition;experimental study;fluorescence imaging;Goals;Growth;Hepatocyte;Image;Image Analysis;Imaging Device;imaging modality;improved;instrumentation;Investments;Light;Liver;Malignant neoplasm of liver;medical schools;member;Microscope;Microscopic;Microscopy;Mission;model organism;Molecular;Morphology;multi-photon;multiphoton microscopy;Mutation;non-alcoholic fatty liver disease;novel imaging technology;operation;Organoids;Pattern;Preparation;problem drinker;Productivity;Publications;Recording of previous events;Research;Research Personnel;Resolution;Resources;Sampling;Services;Signal Transduction;Specimen;Structure;superresolution microscopy;Technical Expertise;Techniques;Technology;Tissue imaging;Tissues;tool;Training;tumor progression;ultra high resolution;United States

PROJECT_TITLE: Morphology Core


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The landmark Adolescent Brain Cognitive Development (ABCD) Study is following over 11,800 children beginning at 9 and 10 years of age in 21 U.S. communities. Over the next 7 years, the study aims to provide critical information about what factors present during their adolescent and young adult years may either strengthen their development or place them at higher risk of poor mental, physical, or behavioral health.

PI_NAMEs: BROWN, SANDRA A;JERNIGAN, TERRY L. (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescent;Adolescent and Young Adult;Affect;Alcohols;Athletic Injuries;Behavior;Behavioral;behavioral health;Bioethics;Bioinformatics;Biological Assay;Blood;Brain;Caffeine;Child;Cognitive;cognitive development;cohort;Communication;Communities;Complex;conflict resolution;Data;Data Analyses;data archive;Data Collection;Data Compromising;data integration;data quality;data resource;Data Set;data sharing;Databases;Dedications;design;Development;Emotional;Enrollment;Ensure;Environment;Environmental Risk Factor;Epidemiology;Epigenetic Process;Ethics;experience;Exposure to;flexibility;follow-up;Funding;gene interaction;Genetic;genome-wide;Genotype;Goals;Hair;high dimensionality;high risk;Hormones;improved;indexing;Individual;Informatics;Institutional Review Boards;Knowledge;Leadership;Link;Liquid substance;Magnetic Resonance Imaging;Marijuana;Measurement;Measures;media use;Mental disorders;Mental Health;Methodology;Methods;mobile computing;Modeling;Monitor;multidimensional data;National Institute of Mental Health;Neurocognition;neuroimaging;Nicotine;novel;open data;Oral;Outcome;Parents;Participant;Physical activity;physical conditioning;Physiological;Policies;Procedures;Process;Protocols documentation;Psychopathology;Puberty;Publications;Quality Control;recruit;Research;Research Personnel;Research Project Grants;Resources;response;retention rate;Role;Sampling;Scanning;Schedule;Secure;Security;Severities;Site;Site Visit;Sleep;Specific qualifier value;Standardization;Strategic Planning;Substance of Abuse;substance use;Technology;Technology Assessment;Time;Tooth structure;Toxic Environmental Substances;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States National Institutes of Health;Visit;wireless;Work;Youth

PROJECT_TITLE: ABCD-USA Consortium: Coordinating Center


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

ORG_CITY: DURHAM

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Urolithiasis (or commonly known as urinary stone disease) is a benign but severely painful genitourinary disease that is on the rise and is the second most costly urologic condition in the US at over $2 billion per year. Despite the technology and technical advances in ureteroscopy (URS) with laser lithotripsy, shock wave lithotripsy (SWL) remains to be the only non-invasive modality for stone patients, easy to use, cost effective, and can often produce stone free rates comparable to URS. We propose to further advance the technology innovations in SWL by creating SAFE (Steerable and Adjustable Focusing Electrohydraulic) shock wave generators, 3D-DCM (3D- Dynamic Cavitation Monitoring) technology, and a miniature wet coupling (MiniCouple) device, applicable to most clinical shock wave lithotripters, to ensure the quality of shockwave source-patient interface for effective acoustic transmission, and to improve the overall treatment outcome while reducing tissue injury and procedure time .

PI_NAMEs: ZHONG, PEI  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: 3-Dimensional;Achievement;Acoustics;Address;American;Anatomy;Award;Benign;Book Chapters;Cells;Characteristics;CHRM3 gene;Clinic;Clinical;Clinical Management;Clinical Treatment;Clinical Trials;Collaborations;Computer Models;cost;cost effective;Coupling;design;Devices;Disease;Dose;Dryness;Electromagnetics;Emergency department visit;Ensure;Feedback;flexibility;Fracture;Frequencies;Gel;Generations;Health Care Costs;High-Energy Shock Waves;improved;Injury;innovation;Journals;Kidney;Kidney Calculi;Knowledge;Laser Lithotripsy;lens;Lithotripsy;Longevity;Manufacturer;materials science;Microfluidics;Modality;Monitor;Motion;new technology;next generation;novel;Pain;Paper;Patients;Percutaneous Nephrolithotomy;Performance;Physics;Physiologic pulse;Play;pressure;Prevalence;Procedures;programs;Public Health;Published Comment;Publishing;real time monitoring;Recurrence;Renal Tissue;Repeat Surgery;Research;Research Activity;research and development;Residual state;respiratory;Risk;Role;Safety;Shapes;Shock;Skin;smart technologies;Source;Surface;Surgical Management;synergism;System;Techniques;technological innovation;Technology;technology development;therapy design;Time;tissue injury;translational potential;transmission process;treatment optimization;Treatment outcome;Treatment Protocols;treatment strategy;ultrasound;United States;United States National Institutes of Health;Ureteroscopy;Urinary Calculi;Urogenital Diseases;urolithiasis;urologic;Urologist;Width

PROJECT_TITLE: Innovations in Shock Wave Lithotripsy Technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-R(90)]


NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

PI_NAMEs: STRAZZABOSCO, MARIO  (contact)

PROJECT_TERMS: Acetaminophen;acute liver injury;Adenovirus Infections;Adult;Animal Model;Animals;autosome;Award;bile duct;Bile fluid;Caco-2 Cells;Cannulations;Cell Culture Techniques;Cell Line;Cell model;cell preparation;Cell Separation;Cells;cholangiocyte;Cholestasis;Cirrhosis;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Collagen;Collection;Complementary DNA;Consultations;Contracts;Core Facility;cost;cost effective;CRISPR/Cas technology;Cystic Fibrosis;Cystic Fibrosis Transmembrane Conductance Regulator;Dedications;Detection;Dimethylnitrosamine;Disease;disease model;Doctor of Philosophy;Endothelial Cells;Endothelium;Enzyme-Linked Immunosorbent Assay;Equipment;Equus caballus;experience;Experimental Models;Fibroblasts;Fibrosis;Fluorescence;Gel;Gene Expression;Genotype;Hepatic;Hepatocyte;HepG2;Human;Human Resources;Image;imaging detection;imaging system;induced pluripotent stem cell;innovation;interest;Kidney Diseases;Knockout Mice;Kupffer Cells;Libraries;Ligation;Liver;Liver diseases;luminescence;Lymphocyte;Maintenance;member;Methods;Modeling;Molecular;monolayer;mouse model;Mus;Mutate;novel;Obstruction;Organoids;Partial Hepatectomy;Patients;Perfusion;Physiology;Portal vein structure;Preparation;Primary Cell Cultures;primary sclerosing cholangitis;Procedures;Productivity;protein expression;Proteins;Quality Control;Quantitative Reverse Transcriptase PCR;Rattus;Reader;Recording of previous events;Reperfusion Injury;Reproducibility;Research;Research Personnel;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA;Rodent;Sampling;Services;Small Interfering RNA;Standardization;stellate cell;Supervision;surgical service;synergism;System;Technical Expertise;Thioacetamide;Time;Tissues;tool;Training;Transfection;Update;vector;Viral Vector;Work

PROJECT_TITLE: Cellular and Molecular Physiology Core


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative UAB is one of the top performing sites of the Neonatal Research Network, leading in enrollment and in the design of innovative and seminal clinical studies. UAB’s participation in rigorously designed studies will identify strategies to reduce mortality and morbidity in neonates and provide evidence to guide neonatal care.

PI_NAMEs: CARLO FONT, WALDEMAR A. (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: 6 year old;Admission activity;Age;Agreement;Alabama;Area;Caring;Clinic;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Committee Members;Data Analyses;Databases;design;Development;Diagnostic;Eligibility Determination;Enrollment;Environment;Evaluation;experience;Faculty;follow-up;Follow-Up Studies;Fostering;Goals;Health Services Research;Healthcare Systems;high risk;improved;Infant;innovation;Institutional Review Boards;Lead;Leadership;Manuscripts;Maternal-Fetal Medicine Units Network;Medicine;meetings;member;Morbidity - disease rate;mortality;Multicenter Neonatal Research Network;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;neonatal care;Neonatal Intensive Care Units;neonatal outcome;neonate;Neonatology;novel strategies;Outcome;Participant;participant enrollment;Pattern;Peer Review;Performance;Perinatal;perinatal health;Phototherapy;Positioning Attribute;programs;Protocols documentation;Publications;Publishing;Randomized, Controlled Trials;Reporting;Reproducibility;Request for Applications;Research;Research Design;Research Personnel;Research Priority;Role;Seminal;Site;Therapeutic;U-Series Cooperative Agreements;Universities;Work

PROJECT_TITLE: NICHD Neonatal Research Network Clinical Center UAB


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Genetics;Nanotechnology;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: BOSTON

ORG_NAME: JOSLIN DIABETES CENTER

ORG_STATE: MA

PHR: Project Narrative Obesity and diabetes are two major health threats in the United States. The proposed research aims to understand the regulation of adipose tissue remodeling in response to environmental signals. The success of the proposed studies will improve our knowledge of in vivo adipogenesis and provide potential therapeutic approaches for the treatment and prevention of obesity and diabetes.

PI_NAMEs: TSENG, YU-HUA  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: Adipocytes;adipokines;adipose derived stem cell;Adipose tissue;angiogenesis;autocrine;Automobile Driving;Blood Vessels;Brown Fat;Calories;Cell Differentiation process;Cell Fraction;Cell Proliferation;Cell Separation;Chromatin;Chromatin Remodeling Factor;combat;comorbidity;Complex;Data;delivery vehicle;Diabetes Mellitus;Disease;Dissociation;DNA Methylation;Endocrine;Endothelial Cells;Endothelium;Energy Metabolism;Epidemic;Epigenetic Process;epigenetic regulation;Fatty acid glycerol esters;FGF9 gene;FGFR3 gene;Fibroblast Growth Factor;fibroblast growth factor 6;fibroblast growth factor 9;gain of function;Gene Expression;Genes;Genetic Transcription;glucose tolerance;Goals;Grant;Growth Factor;Health;histone modification;improved;In Vitro;in vivo;innovation;insulin sensitivity;intercellular communication;Knockout Mice;Knowledge;Ligands;lipid biosynthesis;Lipids;loss of function;Mammals;Maps;Mediating;Metabolic Diseases;Metabolic syndrome;Mitochondria;Modeling;mouse model;Mus;nanoparticle;Nanotechnology;neovascularization;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Nuclear Receptors;Obesity;obesity prevention;Pathology;Pathway interactions;Physiological;Play;precursor cell;programs;Protein Engineering;Proteins;receptor;recruit;Regulation;Research;response;Rodent;Role;Scheme;Signal Transduction;single-cell RNA sequencing;stem cells;Stimulus;success;System;Therapeutic;Thermogenesis;uncoupling protein 1;United States;Vascular Endothelial Cell;Vascularization

PROJECT_TITLE: Fibroblast Growth Factor and Energy Metabolism

STUDY_SECTION: CADO

STUDY_SECTION_NAME: Cellular Aspects of Diabetes and Obesity Study Section[CADO]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Estrogen;Eye Disease and Disorders of Vision;Genetics;Macular Degeneration;Neurodegenerative;Prevention;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Multiple lines of evidence suggest that a specific subtype of antibody inhibits the growth of blood vessels in a sex-specific manner, which may be beneficial or detrimental depending on the context. We will investigate the mechanisms responsible for this sex-specific activity, with the overall goal that understanding this pathway could provide better and more personalized therapeutic approaches to better control the growth of blood vessels.

PI_NAMEs: GELFAND, BRADLEY DAVID (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Affinity;Alzheimer's Disease;angiogenesis;Angiogenesis Inhibitors;Animal Model;Animals;Antibodies;antigen binding;Antigens;Beds;Blood Cells;Blood Vessels;Bone Marrow;Cardiovascular system;Cells;Chemotaxis;Choroidal Neovascularization;chromosome Y loss;Complement;Coronary Arteriosclerosis;Data;Development;Diabetic Retinopathy;dimorphism;Disease;Estradiol;Estrogens;Event;Exhibits;Exudative age-related macular degeneration;Fc domain;Female;Four Core Genotypes;gain of function;Genes;Genetic;genotypic sex;Glean;Goals;Gonadal Hormones;Growth;Guidelines;Heart failure;helicase;Hindlimb;Hormonal;Hormones;Human;human male;IgG1;Immune;improved outcome;inhibiting antibody;insight;Intervention;Ischemia;knock-down;Knock-out;Knowledge;loss of function;Macrophage;Macular degeneration;male;Malignant Neoplasms;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;mosaic loss;Mus;Myocardial Ischemia;Nature;neovascularization;novel;Pathologic Neovascularization;Pathway interactions;Peripheral arterial disease;personalized therapeutic;Physiological;Plasma;Ploidies;Predisposition;Prevalence;prevent;Process;receptor;Regulation;Regulator Genes;response;Risk Factors;Role;segregation;Severities;Severity of illness;sex;sex as a biological variable;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Signal Transduction;Specimen;Stroke;System;Testing;Testosterone;Therapeutic;Tissues;United States National Institutes of Health;Vascular Endothelial Growth Factors;Y Chromosome

PROJECT_TITLE: Mechanistic basis of sexual dimorphism in antigen-independent IgG1 angiogenesis regulation

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Digestive Diseases;Genetics;Human Genome;Liver Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: LIU, CHEN  (contact)

PROJECT_TERMS: Animal Model;Archives;Award;Basic Science;Bile fluid;biobank;Bioinformatics;Biological Specimen Banks;Biometry;career;Charge;ChIP-seq;cholangiocyte;Clinical;Clinical Investigator;Clinical Research;clinical translation;clinically relevant;Collaborations;Communities;Consultations;Data;Data Analyses;Databases;Development;Disease;Environment;exome;experience;Faculty;Feces;Freezing;Funding;genome sequencing;Goals;Hepatology;Human;Human Resources;Image;induced pluripotent stem cell;Industry;Infrastructure;Institution;interest;Knowledge;Laboratories;Link;Liver;member;Metagenomics;MicroRNAs;Molecular;National Institute of Diabetes and Digestive and Kidney Diseases;Organoids;outreach;Paraffin Embedding;Pathologist;patient oriented research;patient registry;Patients;Performance;Peripheral Blood Mononuclear Cell;Plasma;Process;Protocols documentation;Publications;Published Comment;randomized trial;repository;Research;Research Design;Research Personnel;Research Support;Resources;response;Retrieval;Science;Scientist;Services;Shotguns;single-cell RNA sequencing;Specimen;Study Section;systematic review;Time;Tissue Embedding;Tissues;transcriptome sequencing;Translating;Translational Research;United States;United States National Institutes of Health;Universities;Urine;whole genome

PROJECT_TITLE: Clinical - Translational Core


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Narrative Identifying the missing components of the export machinery required for the building of the outer membrane of mycobacteria and understanding how this machinery functions, in a spatiotemporally-controlled manner, to generate new cell wall as the bacilli divide and elongate will provide new opportunities for the development of much needed drugs against tuberculosis and nontuberculous mycobacterial infections.

PI_NAMEs: JACKSON, MARY  (contact)

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Anabolism;analog;Antimycobacterial Agents;Antitubercular Agents;Bacillus;base;Basic Science;Binding;Binding Sites;Biochemical;Biochemistry;Biological Assay;Cell division;cell envelope;Cell membrane;Cell surface;Cell Wall;Cells;Colorado;Complex;Coupling;Cytoplasm;Deposition;design;Development;drug development;Drug resistance;Drug Targeting;Ethionamide;Funding;Genetic;Genus Mycobacterium;Growth;Incidence;inhibitor;innovation;insight;interest;isoniazid;Joints;Knowledge;Lead;Lipids;Maps;Mediating;Medicine;Membrane;Metabolism;Molecular;molecular dynamics;Molecular Probes;Multi-Drug Resistance;multidisciplinary;Multiprotein Complexes;mycobacterial;Mycobacterium tuberculosis;Mycolic Acid;Nature;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;Oklahoma;Pathogenicity;periplasm;Pharmaceutical Preparations;Physiological;Physiological Processes;Play;Predisposition;Process;Proteins;Protons;Reporting;Research Personnel;Research Proposals;Resistance;resistance mechanism;resistant strain;Role;scaffold;Series;Side;Site;small molecule;small molecule inhibitor;spatiotemporal;Structure;Synthesis Chemistry;System;targeted treatment;Therapeutic;Time;Treatment Efficacy;Trehalose;Tuberculosis;Universities;Validation;Variant;yeast two hybrid system

PROJECT_TITLE: MmpL3 as a target for novel anti-TB agents

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer

ORG_CITY: ANN ARBOR

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative The goal of this proposal is to deliver an agent capable of blocking active EGFR dimerization independent of TKI resistant mutations. This approach of targeting selective disruption of active-EGFR dimerization is expected to be safe and effective.

PI_NAMEs: LAWRENCE, THEODORE S;NYATI, MUKESH K. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;Advanced Development;Area;Binding;Biodistribution;Biological Availability;cancer cell;Cancer cell line;cancer imaging;Cancer Patient;cancer therapy;Cell Death;Cell Line;Cell Survival;Cells;chemotherapy;Chronic;Clinical;Clinical effectiveness;Clinical Research;clinically relevant;Data;design;Development;Diagnosis;Dimerization;Dose;Drug Exposure;Drug Kinetics;Effectiveness;efficacy evaluation;Epidermal Growth Factor Receptor;Exposure to;Frequencies;Future;Generations;Genes;Goals;Immunocompetent;improved outcome;In Vitro;in vivo;in vivo evaluation;inhibitor;inhibitor therapy;Knowledge;Luciferases;lung cancer cell;Lung Neoplasms;lung xenograft;Malignant neoplasm of lung;Methods;Modeling;Monitor;mouse model;Mus;mutant;Mutate;Mutation;neoplastic cell;Non-Small-Cell Lung Carcinoma;Normal Cell;novel;Null Lymphocytes;Oncogenic;Oral;Oral Administration;Organ;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Phosphotransferases;Plasma;Positron-Emission Tomography;pre-clinical;Probability;Progression-Free Survivals;protein expression;Protein Tyrosine Kinase;Proteins;receptor;receptor expression;Receptor Protein-Tyrosine Kinases;refractory cancer;Regimen;Research Design;Resistance;Resistance development;resistance mutation;response;Safety;Schedule;Series;small molecule;Specificity;Statistical Models;Study models;targeted agent;Therapeutic;therapy resistant;Tissues;Toxic effect;treatment effect;Treatment Efficacy;Treatment Protocols;treatment response;tumor;tumor progression;Tyrosine Kinase Inhibitor;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Development of a first-in-class mEGFR dimerization inhibitor

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Substance Misuse

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: Project Narrative To understand the mechanism underlying seizures and mental deficits associated with alcohol withdrawal, we propose to investigate the novel hypothesis that altered structure and function of hippocampal newborn neurons underlies alcohol withdrawal seizures and mental deficits. Using state- of-the art methods to map synaptic, neuronal, and functional connectivity as well as to manipulate function of hippocampal neural circuits, we will unveil the direct role of newborn neurons in alcohol withdrawal-associated seizures, cognition, and emotion. Outcomes of this proposal will provide a foundation for understanding and treating alcohol withdrawal syndromes by specifically targeting altered neural circuits. !

PI_NAMEs: SUH, HOONKYO  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: 3-Dimensional;Abstinence;alcohol abstinence;Alcohol abuse;Alcohol dependence;alcohol effect;alcohol exposure;alcohol relapse;Alcohol Withdrawal Seizures;Alcohol withdrawal syndrome;Alcohols;American;Anxiety;associated symptom;Axon;Behavior;Behavioral;Brain;Chronic;Cognition;cognitive function;Dangerousness;Data;Dendritic Spines;density;Dependovirus;designer receptors exclusively activated by designer drugs;Development;Electron Microscopy;Electrophysiology (science);emotional functioning;Emotions;Epilepsy;Euphoria;excitatory neuron;experience;experimental study;Foundations;Functional disorder;gain of function;Genetic;Genetic study;Goals;granule cell;Hippocampus;Hour;Human;Impaired cognition;Impairment;inhibitory neuron;Label;loss of function;Maintenance;Maps;Mediating;Memory impairment;mental function;Methods;Modeling;mouse model;Nature;neural circuit;neural network;neuroadaptation;neurogenesis;Neurons;Newborn Infant;newborn neuron;novel;novel therapeutic intervention;Outcome;Pain;Pathogenesis;pharmacologic;Physical Function;Physiological;Predisposition;presynaptic;presynaptic neurons;Process;Psyche structure;psychologic;rabies viral tracing;Rabies virus;Relapse;Retroviridae;Role;Seizures;Series;Severities;Structure;Symptoms;Synapses;Syndrome;Testing;Tonic - clonic seizures;Vertebral column

PROJECT_TITLE: The role of hippocampal neurogenesis in alcohol withdrawal seizure and cognition

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: The rising incidence of obesity and associated metabolic diseases has increased the urgency of understanding the fundamental mechanisms controlling energy homeostasis, including those that drive healthy vs unhealthy fat tissue expansion in adults. The experiments described in this proposal will advance our understanding of the mechanisms controlling the activation and suppression of fat cell precursors in adults, and highlight the importance of previously unappreciated cell types that dictate fat tissue health and metabolic health in obesity. This knowledge will facilitate our attempts to derive novel therapeutic strategies to uncouple metabolic disease from obesity.

PI_NAMEs: GUPTA, RANA K (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: adipocyte differentiation;Adipocytes;adipokines;adipose derived stem cell;Adipose tissue;Adult;Anatomy;autocrine;Biology;Blood Vessels;Body mass index;Cardiovascular Diseases;Cell Differentiation process;Cell Hypoxia;cell type;Cells;Chronic Disease;Clinical Research;Data;Development;diet-induced obesity;Dominant-Negative Mutation;Doxycycline;Ensure;experimental study;Fatty acid glycerol esters;fatty liver disease;feeding;Fibrosis;Funding;Genetic Models;Health;HIF1A gene;High Fat Diet;Homeostasis;Hyperplasia;Hypertrophy;Hypoxia Inducible Factor;Imatinib;in vivo;Incidence;Inflammation;inhibitor;Insulin Resistance;insulin sensitivity;Intra-abdominal;Knowledge;lipid biosynthesis;Lipids;Maintenance;male;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;Molecular;Mouse Strains;Mus;mutant;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nutrient;Obese Mice;obese person;Obesity;obesity treatment;overexpression;paracrine;Pathologic;PDGFRB gene;pharmacologic;Phenotype;Phosphorylation;precursor cell;preservation;prevent;Production;progenitor;Regulation;Resistance;response;Risk;Role;Serine;Signal Transduction;stem cell function;subcutaneous;Testing;Time;Tissue Expansion;Tissue Model;Tissues;transgene expression;Transgenic Model

PROJECT_TITLE: Establishment and Maintenance of Healthy Adipose Tissue in Obesity


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Disease

PI_NAMEs: MEHAL, WAJAHAT ZAFAR (contact)

PROJECT_TERMS: Area;Award;base;Bile fluid;Biliary;Biology;cholangiocyte;Cholestasis;Collaborations;Communities;Data;Development;Digestive System Disorders;Faculty;Financial Support;Fostering;Functional disorder;Funding;Future;Grant;Hepatology;induced pluripotent stem cell;interest;Investments;Left;Liver;Liver diseases;Manuscripts;member;new technology;novel;Organoids;Pathogenesis;Pilot Projects;Postdoctoral Fellow;primary sclerosing cholangitis;Process;programs;Publishing;Research;Research Personnel;Scientist;Tissues;Universities

PROJECT_TITLE: P and F Program


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Cancer;Climate-Related Exposures and Conditions;Clinical Research;Patient Safety;Prevention;Skin Cancer

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Actinic keratoses are common pre-cancerous skin lesions that can transform into cutaneous squamous cell carcinoma and whose presence may also be associated with increased risk for other types of skin cancer (melanoma and basal cell carcinoma). In this project, we will determine the absolute risks of skin cancer over time in patients with actinic keratosis, which are unknown; assess what skin cancer related follow-up care is currently being provided to patients with actinic keratosis, which is uncharacterized; and develop a skin cancer risk prediction model for patients with actinic keratosis, which has not previously been done. Completion of this project will directly inform recommendations for skin cancer surveillance and early detection in patients with actinic keratosis, a high-risk group comprised of tens of millions of patients each year in the United States that has not been well-studied.

PI_NAMEs: WEHNER, MACKENZIE RACHEL (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Actinic keratosis;Adopted;Advisory Committees;Affect;anti-cancer research;Award;Bachelor's Degree;Basal cell carcinoma;base;Behavioral;beneficiary;biobank;Biological;Cancer Center;cancer epidemiology;cancer risk;career;career development;Caring;Chronic;Clinical;clinical biomarkers;clinical care;clinical decision-making;clinical practice;Clinical Research;Cutaneous Precancerous Condition;Data;Data Set;Data Sources;Dermatology;Development;Development Plans;Diagnosis;Early Diagnosis;Environment;Epidemiology;evidence base;experience;Fellowship;follow-up;Foundations;Frequencies;Funding;Future;Genetic;genetic epidemiology;genetic information;Germ Lines;Goals;Guidelines;Health Services Research;high risk;high risk population;Individual;individual patient;Institution;Investigation;Knowledge;Lesion;Malignant - descriptor;Malignant Epithelial Cell;Malignant Neoplasms;Measures;medical schools;Medicare;Medicare claim;Melanoma;melanoma biomarkers;Melanoma Cell;Mentors;Mentorship;Modeling;Oncology;Patient Care;patient oriented;patient oriented research;Patients;Pattern;Pennsylvania;Performance;Persons;Phenotype;Physicians;Positioning Attribute;Postdoctoral Fellow;predictive tools;professor;Provider;Recommendation;Relative Risks;Reporting;Research;research and development;Research Project Summaries;Residencies;Risk;risk prediction;risk prediction model;Scientist;skills;Skin Cancer;skin squamous cell carcinoma;Squamous cell carcinoma;Sun Exposure;Time;tool;tool development;Training;United States;United States National Institutes of Health;Universities;UV Radiation Exposure;Visit;Work

PROJECT_TITLE: Skin Cancer Risks and Risk Prediction in Patients with Actinic Keratosis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

PI_NAMEs: IWAKIRI, YASUKO  (contact)

PROJECT_TITLE: Enrichment Program


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Emerging Infectious Diseases;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Pediatric;Rare Diseases

ORG_CITY: ATHENS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE This proposal is focused on a glycosylation pathway that when defective leads to congenital muscular dystrophy. This work will elucidate the specificity of the enzymes in the pathway, the impact of disease- causing variants, and uncover novel gene products involved in the pathway that are potentially associated with disease.

PI_NAMEs: WELLS, LANCE  (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Actins;Address;Affect;Animals;Antibodies;Arenavirus;autosome;Basic Science;Binding;Biological Assay;Cardiac;causal variant;Cell Line;Cell membrane;Cells;Cessation of life;Clinical;clinical investigation;cognitive function;Complex;congenital muscular dystrophy;Coupled;CRISPR screen;Cytoskeleton;Data;Defect;Dimerization;Disaccharides;Disease;disease-causing mutation;Disseminated Malignant Neoplasm;Duchenne muscular dystrophy;dystroglycanopathy;Dystrophin;Ensure;enzyme pathway;Enzyme Tests;Enzymes;Extracellular Matrix;Extracellular Matrix Proteins;Frequencies;fukutin;Functional disorder;Funding;Gene Mutation;gene product;Gene therapy trial;Gene Transfer;Genes;Genetic Predisposition to Disease;Glycopeptides;Glycoproteins;glycosylation;Goals;Heterozygote;Human;Human Cell Line;Impairment;improved;In Vitro;Individual;Infection;Intervention;Kinetics;Knowledge;Laminin;Lassa virus;Life;life span;Ligand Binding;Limb-Girdle Muscular Dystrophies;Link;Mammalian Cell;Mannose;Mass Spectrum Analysis;Membrane Proteins;Methods;Muscle eye brain disease;Muscular Dystrophies;Mutation;neural;Neurologic;Northern Europe;novel;overexpression;Pathway interactions;Patients;Peripheral;Phenotype;Polymers;Polysaccharides;Population;Predisposition;protein complex;Proteins;Protocols documentation;receptor;Recombinant Proteins;Research;Role;Series;Severity of illness;Specificity;Structure;Structure-Activity Relationship;System;Testing;Therapeutic;Threonine;tool;Variant;Vesicular stomatitis Indiana virus;Walker-Warburg syndrome;Work;α-Dystroglycan

PROJECT_TITLE: Structure and Function in alpha-Dystroglycan Glycosylation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-C(02)M]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: PROJECT NARRATIVE The scientific understanding of how genomes encode information is being revolutionized by a diverse class of experimental methods known as multiplex assays of variant effect (MAVEs). This proposal will develop a unified computational framework for analyzing the large datasets that MAVEs produce. Our methods will provide unprecedented quantitative insight into how genomic DNA encodes biologically critical information, thus advancing the clinical understanding of human genetic variation and accelerating the development of treatments for a wide range of diseases.

PI_NAMEs: KINNEY, JUSTIN B. (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acceleration;Accounting;Acute;Address;Adopted;Adoption;Architecture;Area;Benchmarking;Biological Assay;Biology;biophysical model;Clinical;Communicable Diseases;computational platform;Computational Technique;Computer Analysis;computer framework;computer infrastructure;Computing Methodologies;Data;Data Set;deep learning;deep neural network;Defect;Development;Dimensions;Discipline;Disease;DNA;Drug Targeting;Effectiveness;Equilibrium;Escherichia coli;Evolution;Experimental Designs;experimental study;Failure;flexibility;Freedom;Gene Expression;Gene Expression Regulation;Genetic;Genetic Models;Genetic Transcription;Genetic Variation;Genome;genome-wide;Genomic DNA;Genomics;Genotype;Goals;Human Genetics;innovation;insight;interest;Joints;Kinetics;large datasets;Maps;Mathematics;Measurement;Measures;Messenger RNA;Methods;Modeling;Modernization;Molecular;molecular phenotype;mRNA Precursor;multiple datasets;multiplex assay;mutation screening;Nature;Neural Network Simulation;Noise;Output;Performance;Pharmaceutical Preparations;Phenotype;Process;Proteins;Publishing;Pythons;Reporter;Reproducibility;Research;Ribonucleic Acid Regulatory Sequences;RNA;RNA Splicing;Science;small molecule;Spinal Muscular Atrophy;success;Techniques;Technology;therapy development;Thermodynamics;transcription factor;Variant;Work

PROJECT_TITLE: A unified quantitative modeling strategy for multiplex assays of variant effect

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Predictive modeling is expected to become a cornerstone on the path to achieving precision/personalized medicine, as one of the key tasks here will be making individualized predictions of disease characteristics/phenotypes like subtype and risk of progression and/or recurrence. We propose several innovative computational algorithms for developing accurate predictive models that integrate diverse clinical and omic data, as well as several rigorous validation exercises that will demonstrate the capabilities of these models. Successful accomplishment of the proposed work will contribute to the advancement of personalized/precision medicine through more accurate individualized prediction of disease characteristics.

PI_NAMEs: SUAREZ-FARINAS, MAYTE  (contact)

PROGRAM_OFFICER_NAME: DAYAL, JYOTI

PROJECT_TERMS: Acceleration;Address;advanced disease;Algorithms;Asthma;Automobile Driving;base;biobank;Caring;Characteristics;Classification;Clinical;Clinical Data;clinical phenotype;cohort;Computational algorithm;Computer software;Computing Methodologies;Data;Data Collection;data format;data integration;data modalities;Data Set;deep learning;design;Disease;Disease Outcome;disease phenotype;Disparate;Disparity;diverse data;Effectiveness;Electronic Health Record;Electronic Medical Records and Genomics Network;Encapsulated;Exercise;feature selection;flexibility;genomic data;Genomics;Goals;Health;heterogenous data;Image;improved;Individual;individual patient;Inflammatory Bowel Diseases;innovation;insight;Institution;Laboratories;Learning;Malignant Neoplasms;Medical center;Medical Imaging;member;Methods;Modality;Modeling;Molecular;Molecular Profiling;multi-task learning;Multiomic Data;multiple datasets;multiple omics;novel;novel strategies;outreach;patient population;Patients;Performance;personalized medicine;personalized predictions;Phenotype;Physicians;Population;precision medicine;predictive modeling;programs;progression risk;random forest;rapid growth;Recurrence;repository;Research Personnel;Risk;Sampling;scale up;Structure;Techniques;Technology;Testing;The Cancer Genome Atlas;transcriptomics;Validation;Variant;vector;Work

PROJECT_TITLE: Integrating genomic and clinical data to predict disease phenotypes using heterogeneous ensembles

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infant Mortality;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Public Health Relevance The NRN is designed to perform multi-site interventional trials and observational clinical studies in newborns, particularly low birth weight infants. These studies are designed to improve healthcare and outcomes for high risk newborns and infants.

PI_NAMEs: WYCKOFF, MYRA HELEN (contact)

PROJECT_TERMS: 2019-nCoV;African American;African American population;Age;biobank;Birth;Black American;Black race;Blood;Caring;Child;Clinic;Clinical;clinical center;Clinical Data;Clinical Informatics;clinical infrastructure;clinical practice;Clinical Research;clinical research site;Clinical Trials;Collection;Congenital diaphragmatic hernia;Contracts;Country;COVID-19 pandemic;COVID-19 patient;Data;data access;Data Collection;data sharing;data sharing networks;Delivery Rooms;design;Discipline of obstetrics;Elements;Eligibility Determination;Enrollment;Ensure;ethnic minority;Ethnic Origin;experience;Faculty;Feces;Fetus;follow-up;Fostering;Funding;Goals;Grant;gut microbiome;health disparity;Health Personnel;Healthcare;high risk;High-Risk Pregnancy;Hispanic;Home;Hospitals;Human Milk;improved;Individual;Infant;Infrastructure;Institutional Review Boards;International;Intervention Trial;Lactation;Latino;Lead;Low Birth Weight Infant;Medical;Medical center;Metabolic syndrome;Milrinone;Multi-Institutional Clinical Trial;Multicenter Neonatal Research Network;Multicenter Trials;National Institute of Child Health and Human Development;Neonatal;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care;neonatal resuscitation;neonate;Neonatology;neurodevelopment;Newborn Infant;Nutritional;Observational Study;Outcome;Oxygen;Participant;participant enrollment;patient population;Patient Recruitments;Patients;pediatric department;pediatric pharmacology;Perinatal;perinatal intervention;perinatal medicine;Persons;Placenta;Population;Population Heterogeneity;Pregnant Women;Preparation;Primary Care;Principal Investigator;Process;programs;Protocols documentation;public health relevance;Publications;racial minority;randomized trial;randomized, clinical trials;Reapplication;Recording of previous events;Reproducibility;Research;Research Infrastructure;Research Personnel;Resources;Resuscitation;Sampling;Science;service delivery;Site;Telemedicine;Texas;Tissues;Underrepresented Minority;United States;Universities;University Hospitals;Urine;Work

PROJECT_TITLE: NICHD COPPERATIVE MULTICENTER NEONATAL RESEARCH NETWORK


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PHR: NARRATIVE The landscape of biomedical research in the United States is changing, as are the composition and activities of the biomedical research workforce. With this evolution comes an increasing need to encourage talented medical students to pursue careers that will contribute to a better understanding of the factors that promote the diseases under investigation, the development of methodologies to predict and/or prevent disease progression, and the discovery of therapies that will help cure patients. The Summer Medical Research Internship (SMRI) at the University of Virginia addresses this need by providing medical student trainees with an immersive research experience within a rich allergy and infectious diseases research community that boasts strong and diverse basic science and opportunities for exposure to the practice and challenges of providing clinical care to patients. The overall goal of the SMRI is to provide our summer trainees with the knowledge, tools and motivation to consider how they might contribute to the discoveries of the future as physician-scientists and/or members of collaborative research teams.

PI_NAMEs: HALME, ADRIAN J;PETRI, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Area;Basic Science;biodefense;Biomedical Research;career;Career Choice;Clinical;clinical care;Clinical Medicine;Communicable Diseases;Communication;Communities;Development;Education;Educational workshop;experience;Exposure to;Faculty;Goals;hands on research;Hour;Hypersensitivity;Infectious Diseases Research;innovation;interest;Internships;Medical Research;Medical Students;member;Mentors;Mentorship;Mission;National Institute of Allergy and Infectious Disease;next generation;Oral;Physicians;programs;Research;Research Personnel;Scientist;Series;skills;synergism;Training;Universities;Virginia;Writing

PROJECT_TITLE: Biodefense & Infectious Diseases Short-Term Training to Increase Diversity in Biomedical Research

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: PROJECT NARRATIVE The NICHD Neonatal Research Network (NRN) conducts randomized clinical trials and large-scale observational studies in critically ill newborns. Cincinnati Children’s Hospital Medical Center has been a productive site in the NRN for over 30 years. We will continue to work collaboratively to develop and implement significant and innovative protocols and recruit and retain a large number of subjects, with the ultimate goal of improving outcomes for preterm and critically ill newborns.

PI_NAMEs: MERHAR, STEPHANIE L (contact)

PROJECT_TERMS: Admission activity;Basic Science;Beds;Biology;Brain Injuries;Caring;Child;Clinical;clinical center;Clinical Nursing;Clinical Research;clinical research site;Clinical Trials;Collaborations;Complex;COVID-19 pandemic;critically ill newborn;Data Coordinating Center;data quality;Databases;experience;Faculty;Family;fetal opioid exposure;follow-up;Funding;Goals;Hospitals;Immunology;improved outcome;Infant;Infrastructure;innovation;Leadership;Lung;Medical;Medical center;Medicine;Modeling;Multicenter Neonatal Research Network;Multicenter Trials;multidisciplinary;National Institute of Child Health and Human Development;Neonatal;Neonatology;Network Infrastructure;neurodevelopment;Newborn Infant;Nursing Research;Observational Study;patient population;Patients;Pediatric Hospitals;Peer Review;Performance;Perinatal;Pharmacology;Population;population based;Pregnancy;premature;Principal Investigator;Process;Productivity;programs;Protocols documentation;racial diversity;randomized, clinical trials;Recording of previous events;recruit;Reproducibility;Research;Research Infrastructure;Research Personnel;Research Support;retention rate;School-Age Population;screening;Site;Socioeconomic Status;Translational Research;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: NICHD Neonatal Research Network -- Cincinnati Clinical Center


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE. Our multidisciplinary team will leverage our collection of existing biospecimens from pregnant women and their neonates exposed to natural SARS-CoV-2 infection or COVID-19 mRNA vaccines to characterize the functional impact of maternal-fetal antibody transfer. We will investigate the fetal immunostimulatory activity by SARS-CoV-2 immune complexes, map the breadth of transfer of antiviral and autoreactive antibody epitopes, and identify placental biomarkers of differential antibody transfer. This project will generate data of immediate relevance to vaccine development to optimize protection for both the mother and fetus against SARS-CoV-2 and other emerging infections. 1

PI_NAMEs: GAW, STEPHANIE LINA (contact)

PROJECT_TERMS: 2019-nCoV;Address;Adult;Antibodies;Antibody Repertoire;Antibody Response;antibody transfer;Antigen-Antibody Complex;Antigens;Autoantibodies;autoreactivity;Biological;Biological Assay;Biological Markers;Biopsy;breakthrough infection;Cells;Child;Collection;Complex;COVID-19;COVID-19 detection;COVID-19 severity;COVID-19 vaccination;cross immunity;cytokine;Data;Development;Disease;Emerging infection;Epitopes;Exposure to;fetal;fetal immunity;Fetus;Future;Goals;Human;human coronavirus;Hybrids;Immune;Immune response;Immunity;immunogenic;Immunoglobulins;in utero;Infant;Infection;Inflammation;innovation;Lasers;Libraries;Maps;Mass Spectrum Analysis;Maternal antibody;Maternal Exposure;Maternal-Fetal Exchange;Maternally-Acquired Immunity;Mediating;Messenger RNA;Microdissection;Mothers;multidisciplinary;neonatal immunity;neonate;neutralizing antibody;Newborn Infant;novel;novel marker;Patients;Peptides;Perinatal Infection;Phage Display;Phage ImmunoPrecipitation Sequencing;Placenta;placental transfer;Plasma;Play;Population;post pregnancy;post SARS-CoV-2 infection;Pregnancy;Pregnant Women;Prospective cohort;protein expression;Proteome;Proteomics;response;RNA vaccination;RNA vaccine;Role;Sampling;SARS-CoV-2 antigen;SARS-CoV-2 infection;SARS-CoV-2 variant;Secondary to;T-Lymphocyte;Technology;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Umbilical Cord Blood;Vaccination;vaccination strategy;vaccine development;Viral;Viral Antibodies;Viral Antigens;Virus Diseases;Work

PROJECT_TITLE: Investigating the role of maternal-fetal crosstalk on neonatal immunity in COVID-19 infection or vaccination in pregnancy


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Hearing Loss;Infectious Diseases;Otitis Media;Pediatric

ORG_CITY: ATLANTA

ORG_NAME: GEORGIA STATE UNIVERSITY

PHR: Project Narrative - Relevance to Public Health  Otitis media (OM) is the most common childhood bacterial infection, accounting for 24.5 million visits and costing over $5 billion annually, and is also the leading cause of conductive hearing loss in children mainly caused by mucus overproduction, the hallmark of OM. Currently available vaccines have limited serotype coverage and inappropriate antibiotic treatment increased antibiotic resistance substantially, and there is thus an urgent need for developing novel therapeutic strategies to suppress mucus overproduction. The currently proposed studies will lead to the identification of novel therapeutic targets, leading to new therapeutic strategy for inhibiting mucus overproduction in OM.

PI_NAMEs: LI, JIAN-DONG  (contact)

PROGRAM_OFFICER_NAME: WATSON, BRACIE

PROJECT_TERMS: Accounting;Acute;Adenosine;airway epithelium;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Bacterial Infections;Childhood;childhood hearing loss;Chronic;Clinical;Communicable Diseases;Conductive hearing loss;cost;Data;defense response;Development;Disease;Down-Regulation;Economic Burden;Epithelial Cells;Foundations;Goals;Health;Homeostasis;human disease;In Vitro;Inflammation;innovation;Link;Lung infections;Lysine;Mediating;middle ear;Molecular;mouse model;MUC5AC gene;MUC5B gene;Mucins;Mucociliary Clearance;Mucosal Immune Responses;Mucous body substance;Mucous Membrane;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Obstruction;Otitis Media;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Phosphorylation;Play;Polyubiquitination;Production;protein degradation;Protein Kinase;Proteins;Public Health;Regulation;Role;Serotyping;Signal Transduction;socioeconomics;Solid;Streptococcus pneumoniae;Streptococcus pneumoniae plY protein;Testing;Therapeutic;Therapeutic Agents;Threonine;TLR2 gene;Toll-like receptors;ubiquitin isopeptidase;Ubiquitination;Up-Regulation;vaccine access;Vaccines;virtual;Virulence Factors;Visit

PROJECT_TITLE: Novel regulation of mucosal innate defense by AMPK in Otitis Media

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-Y(02)M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative State of the art methods for the early detection and monitoring of cancer are either invasive, time-consuming, expensive, or frequently inaccurate, which hinders the routine screening of at risk-patients to improve survival rates. Here, we propose a portable neural network enabled spectroscopy platform to diagnose cancer in patient biofluids (saliva, blood plasma, and sweat). The expected outcome is to deliver a novel point of care liquid biopsy platform to better classify, monitor, and improve diagnostic sensitivity of a broad range of diseases and conditions, with focus on early/late-stage head and neck cancer.

PI_NAMEs: CARNEY, RANDY ;GOMEZ DIAZ, JUAN SEBASTIAN  (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: absorption;accurate diagnostics;Address;Algorithms;Benign;Biological Markers;Biopsy;Biosensor;Blinded;Blood;Calibration;Cancer Control;Cancer Detection;cancer diagnosis;cancer type;circulating biomarkers;Classification;Clinical;clinical diagnosis;cohort;Complex;Computer software;Consumption;Data;data streams;deep neural network;design;Detection;detection limit;detector;Devices;Diabetes Mellitus;Diagnosis;Diagnostic;Diagnostic Sensitivity;Disease;Dryness;Early Diagnosis;Economics;effective therapy;Electromagnetics;Elements;Fingerprint;Foundations;Fourier Transform;Fourier transform infrared spectrometry;Future;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Head and Neck Surgery;Health Status;Heart Diseases;Heterogeneity;high reward;high risk;Histopathology;Image;imaging modality;Immunohistochemistry;improved;improved outcome;Individual;infrared spectroscopy;innovation;interdisciplinary approach;Interferometry;Label;learning network;Libraries;Light;liquid biopsy;Liquid substance;Machine Learning;machine learning algorithm;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;Measures;Metabolic;Metabolic Diseases;metabolomics;Methods;miniaturize;Modeling;Monitor;Monitoring for Recurrence;multidisciplinary;multiplex detection;nano;nanopattern;nanoplasmonic;Neck Cancer;neural network;neural network architecture;Neural Network Simulation;novel;Otolaryngology;Outcome;Output;Pathology;patient stratification;Patients;Performance;Plasma;plasmonics;point of care;portability;Process;Raman Spectrum Analysis;Rapid diagnostics;rapid testing;Recurrence;Risk;routine screening;Saliva;Sampling;segregation;sensor;Signal Transduction;smartphone application;Solid;Specificity;Spectroscopy, Fourier Transform Infrared;Spectrum Analysis;Spottings;Staging;Statistical Data Interpretation;Survival Rate;System;Techniques;Technology;Testing;Time;tool;Translating;Update;voltage;wearable device;Width;Work

PROJECT_TITLE: A miniaturized neural network enabled nanoplasmonic spectroscopy platform for label-free cancer detection in biofluids

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Prevention

ORG_DEPT: PSYCHOLOGY

PHR: PROJECT NARRATIVE Increasingly, prevention-minded gerontologists and geroscientists look to midlife as the life stage offering a terrific opportunity to prevent or delay the multiple diseases that shrink older adults’ health span, and they call for more knowledge about aging during midlife. We propose to follow up at age 52 a cohort of 1037 infants studied since birth, the Dunedin Study, to quantify how fast or slowly each cohort member is aging in each of 8 different life domains: the pace of biological aging, functional aging, facial aging, social aging, sexual aging, inflammatory aging, microvascular aging, and cognitive aging (Aim 1). We will generate new knowledge about the early-life antecedents of each of the 8 kinds of aging (Aim 2), and about the risk each kind of aging poses for late-life disease (Aim 3), and we will export to the field DNAmethylation blood-test measures of 8 kinds of aging.

PI_NAMEs: CASPI, AVSHALOM ;MOFFITT, TERRIE E (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Age;Aging;aging related;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Animals;Anxiety;Arousal;Asthma;Back;balance testing;Behavioral;Belief;Binding;Biological Markers;Birth;Black race;Blood;Blood Tests;Caliber;Cardiovascular Physiology;Childhood;childhood adversity;Cities;Cognitive aging;cohort;Collaborations;Communities;critical period;Data;Data Set;Dementia;Dental;deprivation;Development;Diagnosis;Discipline;Disease;Dissociation;DNA Methylation;Erectile dysfunction;ethnic diversity;Ethnic Population;experience;Face;Fetal Growth;follow-up;Frequencies;Funding;Gait speed;Geroscientist;Goals;Hand Strength;Health;Health Status;healthspan;Heterogeneity;high reward;high risk;Image;Immune;Immune response;In Vitro;Individual;Individual Differences;Infant;Inflammatory;inflammatory marker;innovation;Intercept;Interleukin-6;Kidney;Knowledge;late life;Latinx;Life;Life Cycle Stages;Loneliness;Longitudinal Studies;Lung;Measures;member;Menopause;Mental disorders;Metabolic;Methods;Methylation;microvascular aging;middle age;mild cognitive impairment;Mind;Modeling;multidisciplinary;Names;novel;Obesity;older adult;Ophthalmoscopy;Outcome;Pain;Participant;participant enrollment;peer;Persons;Phase;pre-clinical;prevent;Prevention;Process;programs;prospective;psychosocial;Puberty;Publishing;rate of aging;Reporting;Research;retina blood vessel structure;Risk;satisfaction;Sexually Transmitted Diseases;Smoking;social;Social isolation;Social support;success;System;Testing;Time;Trail Making Test;Urinary Incontinence;vaginal dryness;Verbal Learning;Walking;Work;young adult

PROJECT_TITLE: Aging in 1000 healthy midlife adults: Phase 52 of the Dunedin Study

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: ROCHESTER

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative The mission of the Rochester EHSC is to improve health through the creation of knowledge and discovery of mechanisms by which environmental exposures, singly and in combination, contribute to health risk across the life span, and translating findings into strategies to mitigate risks and improve human health. This mission is achieved by supporting scientific research and translating this research through community engagement and education. Thus, the EHSC provides the framework for the generation of novel research discoveries and their conversion into effective resources for scientists, public health officials, medical professionals, and communities.

PI_NAMEs: LAWRENCE, B PAIGE  (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Address;Affect;Area;Binding;Biological Models;Biometry;Body System;career development;Chemical Exposure;Clinical;collaborative environment;Communities;community engagement;Community Health Education;community partners;community partnership;Complex;Core Facility;Creativeness;data to knowledge;Development;Disease;environmental agent;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Risk Factor;Epidemiology;Epigenetic Process;Event;Faculty;Fostering;Foundations;Future;Generations;Goals;Health;health science research;Health Sciences;Human;human disease;improved;innovation;Institution;inter-institutional;International;International Aspects;Knowledge;Learning;Life;life span;Medical;member;Methods;Mission;Modernization;multidisciplinary;National Institute of Environmental Health Sciences;next generation;novel;Pilot Projects;Positioning Attribute;prevent;Prevention;Process;Program Development;programs;protective factors;Public Health;Research;Research Personnel;resilience;Resources;response;Risk;Risk Factors;risk mitigation;Science;Scientist;Shapes;skills;stem;stem cells;Structure;Students;success;supportive environment;synergism;Talents;tool;Training Programs;Translating;Translations

PROJECT_TITLE: Environmental Agents as Modulators of Disease Processes


NIH_SPENDING_CATS: Prevention

PROJECT_TERMS: Achievement;Address;Administrator;Advisory Committees;Biostatistics Core;Budgets;career;career development;Collaborations;Communication;Communities;community engagement;Core Facility;Disease;Educational workshop;Elements;environmental agent;Environmental Exposure;Environmental Health;Epidemiology;Esapent;Expenditure;Faculty;Feedback;Fostering;Generations;Goals;Health;health science research;Health Sciences;Human;human disease;Human Resources;improved;innovation;interest;International;Knowledge;Leadership;life span;Medical;meetings;member;Mission;multidisciplinary;National Institute of Environmental Health Sciences;novel;operation;Persons;Pilot Projects;prevent;Process;Program Development;programs;Public Health;Research;Research Personnel;Resources;Risk;risk mitigation;Role;scaffold;Science;Scientist;Series;Structure;success;symposium;Talents;Translating;translational approach;Universities;web site

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Substance Misuse

ORG_CITY: EAST LANSING

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Public Health Relevance This project examines how young people’s perceived negative treatment based on multiple social characteristics contribute to the initiation and persistence of substance use from late childhood to middle adolescence, exploring moderating mechanisms at biobehavioral (i.e., sleep) and environmental (i.e., neighborhood) levels. By investigating perceived negative treatment and substance use as early as late childhood, the project prospectively disentangles directionality and reciprocal associations between the study variables, identifies sensitive periods when perceived negative treatment is particularly harmful, explores sleep and neighborhood environment as modifiers for targeted interventions, and highlights critical developmental periods when interventions may be most effective in mitigating health disparities. The proposed project advances developmental and health disparities science by elucidating biobehavioral and environmental mechanisms linking social experiences of perceived negative treatment to substance use disparities.

PI_NAMEs: WANG, YIJIE  (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: 10 year old;actigraphy;Address;Adolescence;Adolescent;adolescent substance use;Adopted;Adult;Age;base;behavioral health;biobehavior;Brain;Buffers;Categories;Child;Childhood;cognitive ability;cognitive development;Country;Crime;critical developmental period;Data;Data Collection;deprivation;Development;Disadvantaged minority;Discrimination;early adolescence;Emotional;Environment;Environmental Risk Factor;Equity;Ethnic Origin;evidence base;Exclusion;experience;follow-up;Goals;Hair;Health;Health behavior;Health Disparities Research;health disparity;health inequalities;Immigration;indexing;Individual;innovation;insight;Intervention;Life;Link;Longitudinal Studies;marginalized population;Measures;Mental Health;Methodology;Minority Groups;minority health;minority health disparity;Modeling;Motion;National Institute on Minority Health and Health Disparities;Neighborhoods;Noise;novel;Outcome;Parents;Patient Self-Report;perceived discrimination;Persons;physical conditioning;Physiological;Population;Prejudice;programs;prospective;psychosocial;Public Health;Race;Reduce health disparities;Reporting;Research;Risk;Risk Factors;Role;Sampling;Science;Sex Orientation;Shapes;Sleep;Sleep disturbances;sleep health;social;social factors;Stress and Coping;substance use;Testing;Time;Weight;Work;Youth

PROJECT_TITLE: Discrimination and Adolescent Substance Use: Understanding Moderating Mechanisms of Sleep and Neighborhood Environment in the ABCD Study

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Menopause;Prevention;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Cardiovascular disease is the leading cause of death of females in the United States, and females experience a steep increase in cardiovascular disease risk after menopause; females who complete menopause early (before age 46 yrs.) have a higher risk of cardiovascular disease and hypertension than those who complete menopause at a typical age (~ 51 yrs.) The proposed study will investigate autonomic mechanisms underlying dysregulation of blood pressure in early- and typical-age-menopausal females of diverse backgrounds, thereby elucidating factors that contribute to adverse cardiovascular health outcomes associated with early menopause. Findings from this research will lay the groundwork for development of prophylactic and therapeutic approaches to reduce cardiovascular disease risk in postmenopausal females and specifically in early-menopausal females.

PI_NAMEs: LEE, EMMA JEAN (contact)

PROGRAM_OFFICER_NAME: CHEON, YEWON

PROJECT_TERMS: Age;Aging;Award;Blood flow;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Blood Vessels;burden of illness;Cardiac;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;career;career development;Cause of Death;community engaged approach;coping;Data;decrease resilience;Development;Development Plans;Discrimination;economic impact;Environment;Estrogen deficiency;Estrogens;ethnic diversity;experience;Fellowship;Female;Forearm;Foundations;Functional disorder;Future;Goals;Gonadal Steroid Hormones;Grant;Hand;Health;health equity;high risk;Hypertension;Impairment;improved;indexing;Individual;insight;Knowledge;Link;Measures;Mediator;medical schools;Menopause;Mentors;Minnesota;Mission;Morbidity - disease rate;mortality;Muscle;National Heart, Lung, and Blood Institute;Nerve;Outcome;Participant;Patients;perceived discrimination;Persons;Physiological;Physiology;Play;Plethysmography;Population Heterogeneity;Postmenopause;Premature Menopause;Premenopause;Prevalence;Prevention approach;Prevention strategy;prophylactic;Race;racial population;Regulation;Research;response;Rest;Risk;Risk Factors;Role;Scholarship;Stress;stressor;Sympathetic Nervous System;targeted treatment;Techniques;Testing;Therapeutic;Training;treatment strategy;United States;United States National Institutes of Health;Universities;Vascular resistance;vasoconstriction;Venous;Women's mortality;Work

PROJECT_TITLE: Vascular regulation in postmenopausal females


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_NAME: CLARK ATLANTA UNIVERSITY

PHR: PROJECT NARRATIVE The U-RISE Program at Clark Atlanta University is designed to foster a STEM-focused cohort of academically promising undergraduate students via a well-designed series of preparatory activities, curricular enhancements, and intensive research immersions. Together, with guidance from highly experienced faculty mentors, a collection of assets and capabilities already in place at Clark Atlanta University, and commitment from University administration, U-RISE trainees will be prepared to pursue and complete advanced biomedical research degrees. The proposed program holds great promise for generating a cohort of competitively trained scientists who represent the beneficiaries of national efforts to reduce historical trends of underrepresented minority participation in America’s biomedical research enterprise.

PI_NAMEs: GRAY-SINGH, DANIELLE N. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Academy;African American;Biological;Caliber;Classification;cohort;college;Consultations;design;Development;Doctor of Philosophy;Educational Curriculum;Environment;Evaluation;faculty mentor;Fostering;Foundations;Funding;Historically Black Colleges and Universities;Immersion;innovation;Institution;interdisciplinary curriculum;Investments;Knowledge;large datasets;Measurable;member;next generation;Outcome;Pattern;Positioning Attribute;Preparation;programs;Research;Research Activity;Research Personnel;Science;Scientist;STEM field;student retention;Students;Talents;Training;Training Programs;undergraduate student;Universities

PROJECT_TITLE: U-RISE at Clark Atlanta University

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ORG_CITY: GLASSBORO

ORG_NAME: ROWAN UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative The U-RISE at Rowan University training grant supports research-focused training of underrepresented undergraduate students from the College of Science & Mathematics. This comprehensive training program combines coursework, extensive hands-on biomedically-relevant research experiences, interactive workshops, and networking events to prepare trainees for success in biomedically-related doctoral programs.

PI_NAMEs: KECK, THOMAS MCGOWAN;NUCCI, NATHANIEL V (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Biomedical Research;career;citizen science;Communities;Doctor of Philosophy;Educational workshop;Environment;experience;Fellowship;Goals;Growth;innovation;Institution;interest;Investments;medical schools;Mid-Atlantic Region;outreach;programs;Qualifying;recruit;Research;Research Infrastructure;Research Personnel;Research Training;scientific literacy;skills;Sorbus;STEM career;STEM student;Students;success;summer research;Training;Training and Education;Training Programs;undergraduate education;undergraduate research;undergraduate student;Underrepresented Students;United States National Institutes of Health;Universities

PROJECT_TITLE: U-Rise at Rowan University


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: GEORAS, STEVE N (contact)

PROJECT_TERMS: Address;Advisory Committees;Aerosols;Affect;Animal Model;Animals;Behavioral Sciences;behavioral study;Biological;career development;Clinical;Clinical Research;cohort;Collaborations;Communication;Communities;community engagement;Community Health;community partners;Consultations;Core Facility;Cultured Cells;design;Disease;DNA Methylation;Elements;Ensure;environmental agent;Environmental and Occupational Exposure;Environmental Exposure;Environmental Health;Environmental Impact;Environmental Policy;Environmental Risk Factor;Epidemiology;epidemiology study;Epigenetic Process;Faculty;Feedback;Fostering;Genes;Goals;Health;health science research;Health Sciences;Human;human disease;human subject;Human Subject Research;improved;in vitro Model;Inhalation Exposure;innovation;Interdisciplinary Study;International;Intervention;Investigation;Knowledge;Laboratories;life span;meetings;member;Methodology;Mission;Modeling;multidisciplinary;new technology;Prevention;Process;programs;Public Health;Records;Research;Research Activity;Research Personnel;research study;Research Support;Resources;Risk;Risk Assessment;Risk Management;Sampling;Science;Scientist;Services;Structure;Surveys;Technology;Tissues;tool;Translating;translational pipeline;Translational Research;Universities;Work

PROJECT_TITLE: Integrated Health Sciences Facility Core


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Crohn's Disease;Digestive Diseases;Inflammatory Bowel Disease;Prevention

PHR: PROJECT NARRATIVE This project offers a brand-new paradigm on Crohn’s disease (CD)-associated intestinal strictures that will on the short term delve into novel cellular and molecular mechanisms of intestinal stricture formation and on the long-term will eventually foster the development of specific new drugs. Thus, this proposal is directly relevant to IBD and the goals of the National Institute of Health by benefitting more than half of Crohn’s disease (CD) patients and having a tangible impact on ways to prevent intestinal obstruction and avoid surgical resections. By investigating a previously unidentified role of creeping fat-derived factors promoting smooth muscle hyperplasia via increasing smooth muscle cell proliferation, we will deviate from the traditional notion of immune cell-driven ECM deposition, and instead focus on extraluminal factors responsible for fibrosis and stricture formation.

PI_NAMEs: RIEDER, FLORIAN  (contact)

PROGRAM_OFFICER_NAME: KLAPPROTH, JAN-MICHAEL AXEL

PROJECT_TERMS: 3-Dimensional;Ablation;Actins;Acyl Coenzyme A;Adipocytes;Affect;Animal Model;antifibrotic treatment;Automobile Driving;Carnitine Palmitoyltransferase I;Cell Proliferation;Cells;Cholesterol Esters;Coenzyme A Ligases;Collagen;Complex;Crohn's disease;cytokine;Cytometry;Data;Deposition;Development;Disease;Diverticulitis;Effector Cell;Excision;Exhibits;Exposure to;Extracellular Matrix;Fatty acid glycerol esters;fatty acid metabolism;Feedback;Fibronectins;Fibrosis;Focal Adhesion Kinase 1;Fostering;gain of function;Goals;gut inflammation;Health Benefit;Human;Hyperplasia;Immune;Immunohistochemistry;in vivo;Inflammatory;Integrin Signaling Pathway;Integrins;Intestinal Fibrosis;intestinal injury;Intestinal Obstruction;Intestines;Link;Lipids;loss of function;LoxP-flanked allele;Mediating;Mediator;Mesenchymal;Mesentery;Metabolism;migration;Mitochondria;mitochondrial metabolism;Molecular;mouse model;Mouse Strains;Mus;Muscle;Muscle Cells;muscle metabolism;Muscle Mitochondria;Muscularis Mucosa;Myosin Light Chains;nitrobenzene;Nonesterified Fatty Acids;novel;novel therapeutics;Obstruction;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Penetration;Phospholipids;prevent;Preventive;Proliferating;PTK2 gene;response;Role;Signal Pathway;Smooth Muscle;Smooth Muscle Myocytes;Sodium Dextran Sulfate;Source;Sulfonic Acids;System;temporal measurement;Testing;Therapeutic;Transgenic Mice;Triglycerides;Ulcerative Colitis;United States National Institutes of Health;uptake;Western Blotting

PROJECT_TITLE: Creeping fat and Crohn's disease associated strictures

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Orphan Drug;Pediatric;Precision Medicine;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Rett syndrome (RTT), is a severe neurodevelopmental disorder caused by loss-of function mutations in the X- linked gene Methyl-CpG-binding Protein 2 (MECP2) and characterized by loss of speech and hand skills, problems walking, and repetitive hand movements. Genetic restoration of MECP2 in symptomatic mice can reverse symptoms providing hope that disease-modifying therapies can be created but a lack of biomarkers of treatment-response will impede the development of curative therapies. To address this need, we propose to develop neurophysiological biomarkers that can fulfil a primary Context of Use (COU), an early treatment response biomarker, to facilitate and speed both preclinical and clinical trials of novel therapies in RTT.

PI_NAMEs: MARSH, ERIC D (contact);NEUL, JEFFREY L

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: 3 year old;Acceleration;Address;Affect;Age;Animal Model;Area;Behavioral;Biological Markers;biomarker development;candidate identification;Clinical;Clinical Trials;clinically relevant;cohort;curative treatments;Data;Detection;Development;Disease;disease phenotype;Disease Progression;Early treatment;Electrodes;Electroencephalography;Evaluation;Evoked Potentials;Genes;Genetic;genetic testing;Goals;Hand;Human;human model;improved;Individual;insight;Life;Link;loss of function mutation;Measures;Methods;Methyl-CpG-Binding Protein 2;mouse model;Movement;Mus;neural circuit;Neurodevelopmental Disorder;Neurologic;neurophysiology;novel strategies;novel therapeutics;Persons;pharmacologic;Phase;Phenotype;potential biomarker;pre-clinical;preclinical trial;Procedures;response biomarker;restoration;Rett Syndrome;Seizures;Severities;Severity of illness;Signal Transduction;Site;skills;Speech;Speed;Symptoms;Technology;Testing;therapeutic development;Therapeutic Intervention;Therapeutic Trials;therapy development;Time;tool;Training;Translations;treatment response;trial design;visual tracking;Walking;Work

PROJECT_TITLE: Development of Translatable Neurophysiological Biomarkers to Accelerate Therapeutic Development in Rett Syndrome

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders B Study Section[NSD-B]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Rehabilitation

ORG_CITY: SEATTLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative The long-term goal of this project is a socket that maintains fit without requiring continual attention and adjustment by the user. The project brings novel socket sensing elements, a versatile fob, and electro- mechanical control system strategies to prosthetics to automate socket adjustment during everyday activities. Rigorous testing of the auto-adjusting socket in user free-living environments of comfort, satisfaction, convenience, fatigue, residual limb health, prosthesis use, activities, socket fit and number of manual socket size adjustments provide key insight towards integration of this technology in clinical care.

PI_NAMEs: SANDERS, JOAN E. (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Address;Algorithms;Amputation;Amputees;Attention;clinical care;Clinical Research;Custom;Data;design;Deterioration;Development;Devices;disability;Elements;engineering design;Ensure;Environment;Evaluation;experience;Fatigue;Femur;Focus Groups;Goals;Health;home test;improved;Individual;insight;Knowledge;Laboratories;Life;limb amputation;limb loss;Limb structure;Liquid substance;Manuals;Measurement;model design;Modification;Monitor;novel;Participant;Patient Self-Report;Patients;Performance;performance tests;Persons;preference;Prosthesis;prosthesis wearer;prosthetic socket;Protocols documentation;prototype;Quality of life;randomized trial;Randomized, Controlled Trials;Recovery;remote control;Reporting;Research;Research Design;residual limb health;satisfaction;sensor;Specific qualifier value;Structure;System;Technology;Testing;Time;Update;Upper Extremity;Walking

PROJECT_TITLE: An automatically-adjusting prosthetic socket for people with transtibial amputation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Nutrition

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Diet can affect cancer cell metabolism and nutritional requirements to as large a degree as the oncogenes and tumor suppressor genes. Our preliminary data show that a specific dietary methionine restriction has anti-tumor properties alone or in adjuvant therapy in several cancer models. In this proposal I will dissect the nature of methionine restriction mediated anti-cancer effects for its therapeutic application.

PI_NAMEs: GAO, XIA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Affect;anti-cancer;ATAC-seq;auxotrophy;Betaine;Biochemical Pathway;Biochemistry;Bioinformatics;bisulfite sequencing;cancer cell;Cancer cell line;Cancer Model;cancer therapy;Carbon;career;chemotherapy;ChIP-seq;clinical application;colon cancer cell line;colon cancer patients;Colorectal Cancer;colorectal cancer treatment;cost effective;CRISPR/Cas technology;Cysteine;Cysteine Metabolism Pathway;Data;Diet;dietary;Dietary Intervention;dietary restriction;DNA;DNA Methylation;drug development;Enzymes;Epigenetic Process;epigenomics;Equilibrium;Essential Amino Acids;Evolution;Exhibits;extend lifespan;Fluorouracil;FRAP1 gene;Future;Gene Expression;Generations;Genes;Genetic;Genetic Screening;HCT116 Cells;Health;histone methylation;Human;improved;In Vitro;Insecta;insulin sensitivity;KRASG12D;Laboratories;Learning;life span;Liver;Malignant Neoplasms;Mammals;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methionine;Methionine Metabolism Pathway;Methylation;Modeling;Molecular;Mus;Nature;new therapeutic target;novel therapeutics;Nutritional;Nutritional Requirements;Obesity;Oncogenes;Outcome;Oxidation-Reduction;patient derived xenograft model;pharmacologic;Phase;Physiology;PIK3CG gene;Plasma;Property;Protein Biosynthesis;Radiation;Radiation therapy;Reaction;Regulation;response;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Sarcoma;Soft tissue sarcoma;Sulfur;Supplementation;targeted cancer therapy;Therapeutic;therapy development;Tissues;TP53 gene;Training;transcriptome sequencing;tumor;tumor growth;tumor metabolism;tumor progression;Tumor Suppressor Genes;Workload

PROJECT_TITLE: Understanding methionine metabolism and its therapeutic potential in cancer

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


PI_NAMEs: THURSTON, SALLY W (contact)

PROJECT_TERMS: Address;Advisory Committees;Applications Grants;Area;Biometry;Biostatistical Methods;Biostatistics Core;career development;Collaborations;community engagement;Complex;Computational Biology;Core Facility;Data;data management;Data Science;Development;Disease;doctoral student;environmental agent;Environmental Health;Event;Exclusion Criteria;Faculty;Fostering;Funding;Goals;Grant;Health;health data;health science research;high dimensionality;improved;innovation;Knowledge;meetings;member;Mentors;Mentorship;Methodology;Mission;National Institute of Environmental Health Sciences;novel;Paper;Participant;Pilot Projects;Play;Postdoctoral Fellow;prevent;Process;Program Development;Publications;Recording of previous events;Research;Research Activity;Research Design;Research Personnel;Research Project Grants;research study;Sample Size;Services;Statistical Data Interpretation;statistics;Systems Biology;Talents;Techniques;Training;Training Programs;Work

PROJECT_TITLE: Biostatistics Facility Core


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: Project Narrative Individuals with neurofibromatosis type 1 (NF1) have a dramatically increased risk of developing malignant peripheral nerve sheath tumors (MPNST), a leading cause of death for NF1 patients. This project will investigate cellular and molecular mechanisms from a developmental defect-induced nerve injury to malignant transformation during NF1-MPNST formation.

PI_NAMEs: ZHU, YUAN  (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Axon;axonal degeneration;Benign;Cause of Death;CDKN2A gene;Cell Lineage;Characteristics;Chromatin;Complex;Data;Defect;derepression;Development;Dissociation;drug repurposing;effective therapy;Embryonic Induction;embryonic stem cell;Environment;epigenomics;Foundations;Gene Expression;gene repression;Genetic;genetic signature;Genome;Growth;histone modification;Human;in vitro Assay;in vivo;Individual;Induced Mutation;injured;Injury;Integrins;Lesion;Malignant - descriptor;Mediating;MEKs;Molecular;multiple omics;Mus;Mutant Strains Mice;Mutation;myelination;neoplastic cell;Nerve;nerve injury;Neural Crest;Neurodevelopmental Disorder;Neurofibromatosis 1;Neurofibrosarcoma;NF1 gene;novel therapeutic intervention;novel therapeutics;Oncogenic;Patients;Peripheral Nerve Sheath Neoplasm;Peripheral Nerves;Plexiform Neurofibroma;Polycomb;Pre-Clinical Model;Predisposition;prevent;Preventive;Proliferating;Regulation;Repression;response to injury;Risk;Role;Schwann Cells;Solid;Sorting;stem cell differentiation;stemness;Technology;Testing;Therapeutic;TP53 gene;transcriptomics;Treatment Protocols;tumor;Tumor Suppressor Genes;Tumor Suppressor Proteins

PROJECT_TITLE: Developmental Origin, Injury and Epigenomic Regulation of NF1-Associated Peripheral Nerve Sheath Tumors

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focuses on evaluating the role of psychosocial stress on the cognitive health of Latinx adults, who have a 50% greater risk of Alzheimer’s disease and related dementias compared to non-Latinx White adults. This research will characterize the daily linkages between experiences with discrimination and cognitive performance in Latinx adults. Results from the proposed research will inform on mechanisms of cognitive health inequities and uncover protective factors in these processes to inform future prevention and intervention efforts aimed at reducing cognitive health inequities in Latinx adults.

PI_NAMEs: MUNOZ, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Address;Adult;Adverse effects;Age;age related;Alzheimer's disease related dementia;Alzheimer's disease risk;Anxiety;anxiety symptoms;Area;Attention;Buffers;Chronic stress;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;cognitive task;cognitive testing;Country;critical period;Data;Data Collection;depressive symptoms;Development;Discrimination;Disparate;Distress;Ecological momentary assessment;economic disparity;ethnic discrimination;ethnic diversity;Ethnic Origin;experience;Feeling;flexibility;Future;handheld mobile device;Health;Health Disparities Research;health inequalities;Hispanic;Hour;Impairment;Individual;Individual Differences;innovation;Intervention;Language;late life;Latinx;Latinx population;Life;life span;Linguistics;Link;Loneliness;Measures;Mediating;Memory;Mental Health;Mexican;middle age;National Institute on Aging;negative affect;older adult;Older Population;Outcome;Participant;perceived discrimination;Performance;Persons;physical conditioning;Population;Population Study;Prevention;Process;protective factors;Protocols documentation;psychologic;Psychological Tests;psychosocial;psychosocial resources;Psychosocial Stress;psychosocial stressors;Public Health;racial diversity;Research;Research Personnel;resilience;Resources;response;Risk Factors;Role;Sampling;Selection Bias;social;Source;Spanish/English;Stress;Surveys;Testing;Texas;Time;United States;Well in self

PROJECT_TITLE: Perceived Ethnic Discrimination and Cognitive Function in Mexican-origin Adults


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Pancreatic cancer is a highly lethal malignancy with no available effective therapies. In this project, we identify and validate novel metabolic dependencies that pancreatic tumors rely on, including unconventional means for producing small, nitrogen-enriched metabolites termed “polyamines” that are essential for cellular growth. We aim at demonstrating that pancreatic tumors produce these metabolites in a very distinct manner than normal cells, thus providing a therapeutic window for intervention to suppress pancreatic cancer growth with minimal toxicity to normal tissues.

PI_NAMEs: KALAANY, NADA Y. (contact)

PROJECT_TERMS: Acetylation;Address;Adult;Affect;Amines;Area;arginase;Arginine;ATAC-seq;Automobile Driving;Binding;Biology;Cancer Etiology;Cancer Patient;cell growth;Cell Physiology;Cell Survival;Cells;Cessation of life;Charge;ChIP-seq;Chromatin;chromatin modification;Chromatin Structure;Cultured Cells;Data;Databases;Dependence;Diagnosis;Dose;Doxycycline;Ductal Epithelial Cell;effective therapy;Enhancers;Enzyme Inhibition;Enzymes;Epigenetic Process;experimental study;Extinction;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genetically Engineered Mouse;Glutamine;Goals;Growth;high risk;Histone H3;Histones;Homeostasis;Human;In Vitro;in vivo;Incidence;infancy;Infusion procedures;Intercellular Fluid;Intervention;Investigation;knock-down;Knock-out;KRAS2 gene;Label;Lysine;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;Metabolic Pathway;Metabolism;mouse model;mRNA Translation;Mus;Nature;neoplastic cell;Nitrogen;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Nucleic Acids;Nucleotides;nutrient metabolism;Oncogenic;Ornithine;Ornithine Decarboxylase;Ornithine-oxo-acid aminotransferase;Pancreas;pancreatic cancer patients;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;pancreatic neoplasm;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Polyamines;Production;Prognosis;Proteins;Putrescine;Risk;Risk Factors;Role;side effect;Source;Spermidine;Spermine;stem;success;Survival Rate;Therapeutic;therapy resistant;Tissues;Toxic effect;transcription factor;Transcriptional Activation;transcriptome sequencing;Translations;Transplantation;tumor;tumor growth;tumorigenic;Withdrawal;Work

PROJECT_TITLE: Role of Altered Nutrient Metabolism in Pancreatic Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

PI_NAMEs: KORFMACHER, KATRINA S (contact)

PROJECT_TERMS: Address;Advisory Committees;Air;Anthropology;Area;Awareness;Behavior;built environment;Cities;Collaborations;Communication;Communities;community advisory board;community center;community engagement;community organizations;Community Participation;community partners;community partnership;Complement;Core Facility;Coronavirus;Country;data to knowledge;Disease;drinking water;Education;Educational Materials;Environment;environmental agent;Environmental Health;environmental health disparity;environmental justice;Equity;Event;evidence base;experience;Faculty;Feedback;Fostering;Goals;Government Agencies;Growth;Health;health equity;health equity promotion;health literacy;Health Professional;Health Promotion;Health Sciences;Home;improved;Indoor Air Quality;innovation;Institution;Intervention;Lead;Lead Poisoning;Learning;lectures;meetings;member;Modeling;National Institute of Environmental Health Sciences;Newsletter;novel strategies;outreach;Perinatal;Pilot Projects;Plastics;Policies;Policy Maker;prevent;Prevention;Privatization;Problem Solving;Process;programs;Public Health;Publications;racial diversity;Research;Research Personnel;Resources;science education;skills;Source;Strategic Planning;success;System;Translating;Translations;trend;vaping;Virus Diseases;web site;webinar;Work

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: Project Narrative The intestine is a highly dynamic tissue with stem cells supporting the ability to grow and adapt. We propose to use the Drosophila midgut and mouse intestine as complementary genetic models to study the conserved mechanisms involving sensing of mechanical signals by the Tao kinases to regulate stem cells for adaptive growth. The result obtained should provide insights into therapeutic strategies for treatment of gastrointestinal disorders such as inflammatory bowel disease and cancer that requires adaptive growth as a repair mechanism.

PI_NAMEs: IP, Y. TONY (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Adult;Affect;Anatomy;Atrophic;bariatric surgery;Biological Assay;Biology;cell type;Cells;Complement;Complex;conditional knockout;Cultured Cells;Drosophila genus;Eating;EGF gene;Epithelial Cells;Epithelium;Excision;Experimental Genetics;experimental study;flexibility;Food;Gastrointestinal Diseases;Gastrointestinal tract structure;Generations;Genetic;Genetic Models;Genetic study;Genetic Techniques;Goals;Growth;Homeostasis;Homologous Gene;Human;Immune response;in vivo;Individual;Inflammatory Bowel Diseases;Ingestion;insight;intestinal epithelium;Intestinal Mucosa;Intestines;Intravenous;Ion Channel;Knock-in;Knock-out;knockout gene;Life Cycle Stages;Link;Malignant Neoplasms;Mammals;MAP4K4 gene;mechanical signal;Mechanics;mechanotransduction;Mediating;Membrane;Metabolic Control;Microbe;Midgut;model organism;Modeling;Molecular;Mus;novel;nutrient absorption;Operative Surgical Procedures;Organ;particle;Pathologic;Pathway interactions;Patients;Personal Satisfaction;Phenotype;Phosphotransferases;Physiological;Physiology;precursor cell;Process;Proliferating;protein protein interaction;Proteins;Radiation therapy;Regulation;repaired;response;Signal Transduction;Small Intestines;Solid;stem cell proliferation;stem cells;Stomach;Stretching;Supporting Cell;System;Therapeutic;tissue regeneration;tissue stem cells;Tissues;tool;Total Parenteral Nutrition;Transcription Coactivator;treatment strategy

PROJECT_TITLE: Conserved mechanisms in epithelial niche regulation of intestinal stem cells

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]