NIH_SPENDING_CATS: Clinical Research;Genetics;Hearing Loss;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Hearing loss and balance dysfunction affect millions of people world-wide with the most common underlying reason being the irreversible loss of specialized sensory cells called hair cells that transmit information about hearing and balance. In this proposal, we use a mouse model to understand the behavior of a limited number of stem cells that are activated after injury to the inner ear, with the goal of deciphering their mechanism of regeneration. Our overarching aim is to identify what molecular pathways can be manipulated to stimulate regeneration following injury in humans to help restore hearing and balance.

PI_NAMEs: JAN, TAHA A (contact)

PROJECT_TERMS: Ablation;Acceleration;Adopted;Affect;Auditory;Award;Basic Science;Behavior;beta catenin;Bioinformatics;Biological;Biology;biomarker identification;Body System;cell behavior;Cell division;Cell Lineage;Cell Maintenance;Cell Proliferation;Cells;Clinical;Data;Decision Making;Development;Disabling;Epithelium;equilibration disorder;Equilibrium;Event;experimental study;Faculty;Functional disorder;Funding;Gene Expression Profile;Genes;Genetic;Genetic Markers;Goals;Grant;hair cell regeneration;Hair Cells;Hearing;hearing impairment;Hearing problem;hearing restoration;Heterogeneity;Homeostasis;Human;in silico;In Vitro;in vivo;in vivo Model;Individual;injured;Injury;insight;interest;Knowledge;Labyrinth;Lead;Learning;LGR5 gene;Location;Maintenance;Mammals;medical schools;member;Mentors;Mitosis;Mitotic;Modeling;Molecular;mouse genetics;mouse model;Mus;Natural regeneration;Neonatal;neonatal injury;neonatal mice;Olfactory Pathways;Operative Surgical Procedures;Organ;Otolaryngology;Otology;overexpression;Pathway interactions;Patients;permanent hearing loss;Persons;Physicians;Population;progenitor;programs;Proliferating;regeneration following injury;regenerative;Regenerative Medicine;regenerative therapy;Research;Scientist;self-renewal;Sensorineural Hearing Loss;Sensory;Sensory Disorders;Signal Transduction;single cell analysis;single-cell RNA sequencing;skills;Skin;small molecule;Somatosensory Cortex;spatiotemporal;stem;stem cell self renewal;stem cells;Supporting Cell;Surgeon;System;Techniques;Technology;Therapeutic;tissue regeneration;Tissues;Training;Training Programs;transcription factor;transmission process;undergraduate student;Utricle structure;Vestibular dysfunction;Vestibular function;vestibular system;Work

PROJECT_TITLE: Single cell analysis of mitotic regeneration in the mouse vestibular system


ADMINISTERING_IC: MD

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MIAMI

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHOLOGY

ORG_FIPS: US

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative: The disproportionate use of exclusionary disciplinary practices (EDPs) in schools among students of color is an important, modifiable predictor of school disengagement, a known determinant of health disparities across the lifespan. Yet, research examining how environmental and neurobiological factors interact to explain racial and ethnic disparities in the associations between EDPs, discrimination, and school disengagement is scarce. The proposed K01 training and research endeavors will support a new and early- stage investigator to become a leader in interdisciplinary research focused on school-based determinants of health and health disparities.

PI_NAMEs: THOMPSON, ERIN L (contact)

PROGRAM_OFFICER_NAME: GARRIDO, CARLOS OSWALDO

PROJECT_TERMS: Academia;Address;Adolescent;Applied Research;Brain;brain volume;Child Health;childhood adversity;Clinical;cognitive development;Color;Complex;coping;COVID-19;Data;density;Development;Discipline;Discrimination;Distal;Distance Learning;Drops;Education;educational atmosphere;ethnic disparity;Evaluation;executive function;experience;Exposure to;falls;Future;health determinants;Health Disparities Research;health disparity;Hybrids;improve minority health;improved;Inequity;Institution;interdisciplinary approach;Interdisciplinary Study;Intervention;Knowledge;knowledge base;Learning;Life;life span;Longitudinal Studies;Mediating;Medical;minority children;minority health;minority health disparity;minority stress;Modeling;Neurites;neurobiological mechanism;Neurobiology;Outcome;pandemic disease;Pathway interactions;perceived discrimination;Performance;Policies;Poverty;Process;programs;Psychologist;Psychopathology;Race;racial disparity;Research;Research Personnel;Risk;Risk Factors;School Drop-Outs;Schools;skills;social;Stress;stressor;Student Dropouts;Students;Suspensions;Testing;Theoretical model;theories;Training;Trauma;United States;Violence;Youth

PROJECT_TITLE: Racial disparities in school discipline: Examining the complex interactions between neurobiological, environmental, and school-based determinants of health within the ABCD Study


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The proposed experiments will systematically dissect the mechanisms by which microcircuits encode and update associations during learning at a cellular resolution difficult to achieve in other model organisms. Because the molecular mechanisms and synaptic organization of learning are conserved, these studies will provide valuable new information applicable to mammalian learning. Because failure to update internal representations is involved in several mental disorders, having a detailed mechanistic understanding of how nervous systems perform these updates would inform translational and clinical approaches to healthy and disordered learning.

PI_NAMEs: NITABACH, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TITLE: Synaptic Microcircuits Underlying Associative Learning

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Pediatric

ORG_CITY: LEXINGTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Project narrative This project will produce a large library of graphics depicting craniofacial anatomy. These graphics will be designed for use in software applications for clinical practice, research, and education, and will help to facilitate rapid and accurate communication.

PI_NAMEs: CLARKSON, MELISSA  (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Adult;Anatomic Models;Anatomy;Clinical;clinical application;Clinical Data;Clinical Medicine;clinical practice;Collection;Communication;Complex;Computer software;Computers;congenital anomaly;Correlation Studies;craniofacial;Data Set;design;Developmental Anatomy;Documentation;Education;Environment;Evaluation;Face;Future;Genotype;Head;Human;Informatics;Libraries;malformation;Maps;Measurement;Medical Education;Medical Illustration;Medical Research;Medicine;Methods;model organism;Morphology;multidisciplinary;Nature;next generation;Ontology;orofacial cleft;Patient Care;Patients;Persons;Phenotype;Physical Anthropology;Play;Population;Positioning Attribute;preservation;Production;prototype;real world application;Research;Role;Severities;Site;skills;Standardization;Terminology;Text;Time;tool;tool development;Variant;vector;Visual;web app;web-based tool;Work

PROJECT_TITLE: Developing standardized graphic libraries for anatomy: A focus on human craniofacial anatomy and phenotypes

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Bioengineering;Biotechnology;Genetics;Lung;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Acute respiratory distress syndrome (ARDS) is an acute inflammation of the lungs, usually leading to 75,000 annual US deaths, but several times that since the start of COVID-19, which can cause ARDS. In ARDS, any of several inflammatory stimuli cause the lungs’ air sacs to develop leaky capillaries and infiltration by white blood cells. Here we will deliver to these air sacs mRNA encapsulated in lipid nanoparticles, which will drive the local expression of therapeutic proteins that will ameliorate both the capillary leak and deleterious white blood cells, potentially providing a new therapy for ARDS.

PI_NAMEs: BRENNER, JACOB ;PARHIZ, HAMIDEH  (contact)

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: Acids;Acute;Acute Respiratory Distress Syndrome;Affect;Air Sacs;Alveolar;Alveolus;Animal Model;Anti-Inflammatory Agents;Antibodies;aspirate;Automobile Driving;Blood capillaries;Body System;cadherin 5;Cell Adhesion Molecules;Cell Count;Cell Physiology;cell type;Cell-Cell Adhesion;Cessation of life;Clinical Trials;Complement;cost;COVID-19;COVID-19 vaccine;Critical Care;Critical Illness;cytokine;Data;Deposition;design;Disease;Dose;Drug Carriers;Drug Delivery Systems;Edema;Encapsulated;Endothelial Cells;Endothelium;Engineering;falls;FDA approved;Flow Cytometry;Functional disorder;Growth;Home;Hour;Human;human tissue;Immunosuppression;improved;in vivo;Infiltration;Inflammation;Inflammatory;Inhalation;Injections;Interleukin-10;Klebsiella pneumoniae;Lavage;Leucocytic infiltrate;leukocyte activation;Leukocytes;lipid nanoparticle;Lipids;Lung;lung injury;Measures;Mediating;Messenger RNA;monocyte;mortality;mouse model;mRNA delivery;Mus;mutant;nanocarrier;nanomedicine;nanoparticle delivery;nanoscale;Nanotechnology;neutrophil;novel drug class;novel therapeutics;Oral;Organ;Organ failure;Pathologic Processes;Pathway interactions;Patients;Perfusion;Pharmaceutical Preparations;Pharmacology;Phenotype;Physicians;Physiological;Process;protein expression;Protein Secretion;Proteins;Publishing;pulmonary arterial pressure;Pulmonary Inflammation;side effect;small molecule;Stimulus;success;Surface;Technology;technology platform;Testing;Therapeutic;therapeutic protein;Time;tissue resource;tool;Transplantation;uptake;virtual

PROJECT_TITLE: mRNA-LNPs for ARDS

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CLEVELAND

ORG_DEPT: NEUROSCIENCES

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: (relevance to public health) This project studies a molecular pathway that, based on studies in rodents and other model organisms, becomes activated and contributes to outcomes in multiple scenarios and axonal injury and stress, nerve damage, chemotherapy, traumatic brain injury, excitotoxicity and models of ALS and Alzheimer's Disease. By understanding the molecular mechanisms of the pathway's activation and downstream actions, which include how it activates the immune system, the findings from this project will guide future therapeutic strategies to promote beneficial outcomes and/or inhibit deleterious outcomes of nervous system damage.

PI_NAMEs: CADIGAN, KENNETH M;COLLINS, CATHERINE A (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Address;Adhesives;Alzheimer's Disease;Axon;axon growth;axon injury;axon regeneration;Axonal Transport;Axotomy;Behavior;biological adaptation to stress;Brain;Categories;Cell Death;cell type;Cells;chemotherapy;Cytoskeleton;disease model;Drosophila genus;Drosophila melanogaster;Excision;excitotoxicity;experimental study;extracellular;Future;Genes;Goals;Immune;Immune response;Immune system;Impairment;Individual;injured;Injury;insight;interest;lens;Mammals;Microglia;Mitogen-Activated Protein Kinases;model organism;Modeling;Molecular;Motor Neurons;mouse model;Mus;Mutation;nerve damage;nerve injury;Nervous System;Nervous System Trauma;neurodegenerative dementia;Neurodegenerative Disorders;Neuromuscular Junction;neuron component;neuron loss;neuronal circuitry;Neuronal Injury;Neurons;Neuropathy;neurotransmission;Organism;Outcome;painful neuropathy;Pathway interactions;Peripheral;Peripheral nerve injury;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Presynaptic Terminals;Process;Public Health;recruit;regenerative;Regulation;repaired;response;restraint;RiboTag;Rodent;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spinal Cord;Stress;stroke model;Synapses;TBI treatment;Technology;Testing;Therapeutic;therapeutic target;Work

PROJECT_TITLE: Regenerative and degenerative responses to axonal injury

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: RAY, KRISTIN N;RUBIO, DORIS M (contact)

PROGRAM_OFFICER_NAME: HARTSHORN, CHRISTOPHER

PROJECT_TERMS: Acceleration;Address;Applications Grants;Area;Articulation;Attention;Award;career;Career Choice;career development;Career Mobility;Clinical;clinical practice;Clinical Research;Clinical Sciences;Communication;Communities;Competence;Complex;Credentialing;Data Science;design;Discipline;Dissemination and Implementation;Doctor of Philosophy;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Elements;Elevator;Emerging Technologies;Ensure;Entrepreneurship;Environment;Evolution;experience;Face;Faculty;flexibility;Focus Groups;Fostering;Funding;Goals;graduate student;Grant;Growth;Health;Health Sciences;implementation science;improved;Individual;Industry;innovation;Institution;Interdisciplinary Study;interest;Intervention;K-Series Research Career Programs;Leadership;Learning;learning community;lens;Life;Medical Students;Mentored Clinical Scientist Development Program;Mentors;Methods;Mission;multidisciplinary;next generation;novel;peer coaching;personalized learning;Phase;Policy Maker;Positioning Attribute;Postdoctoral Fellow;prevent;Professional Burnout;Program Development;programs;promote resilience;Publications;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;research study;Research Training;resilience;response;Scholars Program;Schools;Science;science education;Scientist;Self Care;skills;social media;success;symposium;Technology;Time;TNFSF15 gene;tool;Training;Training and Infrastructure;training opportunity;translational pipeline;Translational Research;translational scientist;Translations;trend;Universities;Vision;Visit;Vocational Guidance;Woman;Work;Writing

PROJECT_TITLE: Institutional Career Development Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Contraception/Reproduction;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Women's Health Research

PHR: Project Narrative The timing (age of onset) and tempo (rate of change) of puberty can significantly and negatively impact psychological, social and physical health, especially in females. Recently, the study team reported signs of early puberty in adolescent females with autism spectrum disorder (ASD), a vulnerable and understudied population. The goal of the project is to comprehensively examine and track the precise onset, course and impact of puberty in 240 females with and without ASD enrolled between 6 to 12 years and follow them for four years to derive data related to pubertal, psychosocial and physiological development to improve education, inform services, and develop interventions, which are lacking.

PI_NAMEs: CORBETT, BLYTHE ANNE (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: 10 year old;Acceleration;Adolescent;adolescent with autism spectrum disorder;Age;age effect;Age of Onset;Anxiety;Area;Arousal;autism spectrum disorder;Behavior;biobehavior;Biological;biological adaptation to stress;biopsychosocial;Body mass index;Breast;Central Nervous System;cohort;Complex;Cross-Sectional Studies;Data;Delayed Puberty;depressive symptoms;Development;Economics;Education;Electroencephalography;Emotional;Endocrine;Enrollment;Entire hair of pubis;Estradiol;Ethnic Origin;Female;Female Adolescents;Genetic;girls;Goals;Growth;Height;Hormones;Human;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Impairment;improved;Intervention;Link;longitudinal design;Luteinizing Hormone;male;Menstrual cycle;Menstruation;Mental Depression;Mental Health;Methods;multimodality;neural;Outcome;peer;peer victimization;Peripheral Nervous System;physical conditioning;Physiological;Plasma;Population;psychologic;Psychological Impact;psychosocial;pubertal timing;Puberty;Race;rate of change;Reporting;Research;research and development;response;Risk;Same-sex;Sampling;Series;Services;Sex Differences;skills;social;social communication;Social Functioning;Social Interaction;social skills;Staging;Stress;Symptoms;Time;Withdrawal

PROJECT_TITLE: Pubertal, Psychological and Physiological Development in Females with Autism


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Vaccine Related

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Graft-versus-host disease (GVHD) remains the major non-relapse complication after allogeneic hematopoietic stem cell transplantion (aHSCTs) for hematologic cancers. Using pre-clinical models, this proposal will identify how innate immune sensors are activated during aHSCT and how the resulting pro-inflammatory signals contribute to GVHD. The proposed research ultimately aims to develop a strategy to prevent or reduce clinical GVHD while maintaining anti-tumor immunity to prevent leukemic relapse.

PI_NAMEs: BADER, CAMERON SCOTT (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;Age;Agonist;Alleles;Allogenic;Attenuated;Award;Bacterial Translocation;cancer vaccination;CD8B1 gene;Cells;Cessation of life;Characteristics;chemokine;chemoradiation;chemotherapy;Clinic;Clinical;comorbidity;Complication;conditioning;curative treatments;Cyclophosphamide;cytokine;cytokine release syndrome;Development;Diagnosis;Disease;DNA;Event;experimental study;frailty;Frequencies;Functional disorder;gastrointestinal;gastrointestinal epithelium;Gene Activation;Generations;graft vs host disease;graft vs leukemia effect;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homologous Gene;Human;Immune;immune activation;immune reconstitution;Immune response;improved;in vivo imaging;Inflammation;Inflammatory;Inflammatory Response;irradiation;Lead;leukemia;leukemia relapse;leukemia treatment;Maintenance;Major Histocompatibility Complex;Malignant - descriptor;Mediating;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural Killer Cells;neoplastic cell;novel therapeutics;Pathway interactions;Patients;Phase;Positioning Attribute;post-transplant;post-transplant disease;pre-clinical;Pre-Clinical Model;prevent;Production;prophylactic;Radiation therapy;reconstitution;Recurrence;Regimen;Regulation;Relapse;relapse risk;Reporting;Research;Residual Neoplasm;Residual state;response;Risk;Role;sensor;Signal Transduction;Stimulator of Interferon Genes;T cell response;T-Lymphocyte;Testing;Tissues;Translating;Transplant Recipients;Transplantation;Transplantation Conditioning;tumor;Tumor Antigens;Tumor Immunity;tumor progression;Tumor Promotion;vaccination strategy

PROJECT_TITLE: The regulation of innate immune sensors to control GVHD and GVL after allogeneic hematopoietic stem cell transplantation


ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: NARRATIVE In this proposal, we describe a systems biology approach to investigate tumor progression and metastasis through the lens of cancer cell states. The proposal involves a strongly complementary collaboration between Dr. White who is an oncologist with expertise in zebrafish cancer modeling, and Dr. Yanai who has expertise in analyzing transcriptional heterogeneity at the single-cell level. Overall this proposal is innovative in its integration of today’s most cutting-edge molecular and cellular methods for the analysis of transcriptomic data, and uses a tractable genetic system that allows us to functionally study and perturb tumorigenesis over space and time.

PI_NAMEs: WHITE, RICHARD MARK;YANAI, ITAI  (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Ablation;Adopted;Atlas of Cancer Mortality in the United States;Biological Assay;Biological Models;Cancer Biology;cancer cell;Cancer Model;cancer therapy;cancer type;cell type;Cells;Clinical;Collaborations;Communities;Complex;Computing Methodologies;Data;Dependence;Detection;Development;Drug resistance;Elements;Environment;experimental study;Fishes;flexibility;Genes;Genetic;Genetic Engineering;genetic manipulation;Genetic Transcription;Goals;Heterogeneity;Human;Image;imaging capabilities;Immune;improved;in vivo;Individual;innovation;insight;lens;Maintenance;Melanoma;Melanoma Tumor;Methods;Modeling;Molecular;mortality;Neoplasm Metastasis;novel;Oncologist;Pharmaceutical Preparations;Play;Publications;Reporter;Research;response;Role;Sampling;single-cell RNA sequencing;Sorting;System;Systems Biology;T-Cell Depletion;T-Lymphocyte;Technology;Testing;Time;transcriptomics;treatment strategy;tumor;tumor heterogeneity;tumor initiation;tumor microenvironment;tumor progression;tumorigenesis;Zebrafish

PROJECT_TITLE: Identification and characterization of cancer cell states by novel computational and experimental technologies - Resubmission - 1


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cardiovascular;Chronic Obstructive Pulmonary Disease;Clinical Research;Heart Disease;Lung;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH SIGNIFICANCE  This research is relevant to public health because it examines patterns in how lung and heart health change over time. We will use repeated imaging studies to identify the earliest, pre-symptomatic changes from young adulthood to midlife to identify susceptible individuals, track transitions from subclinical to clinical disease, and ultimately design prevention strategies for lung and heart disease.

PI_NAMEs: KHAN, SADIYA SANA (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Adult;advanced disease;Affect;Age;Age of Onset;Air Pollution;Ancillary Study;Biological Assay;Biological Markers;Biological Process;Black race;blood-based biomarker;Cardiac;Cardiac health;cardiac magnetic resonance imaging;Cardiopulmonary;Cardiovascular system;Cause of Death;Chronic lung disease;Clinical;clinically relevant;comorbidity;Coronary Artery Risk Development in Young Adults Study;critical period;Data;design;Detection;Disease;disorder prevention;Echocardiography;EFRAC;Elderly;Epidemiology;Event;Evolution;Four-dimensional;Functional disorder;Goals;Health;health care service utilization;Health Transition;Heart;Heart Diseases;Heart failure;hemodynamics;Image;imaging study;Impairment;Individual;Inflammation;Inflammatory;Intervention;Joints;Left;Left ventricular structure;Life;Life Cycle Stages;Link;Lung;Lung Diseases;lung health;lung injury;Magnetic Resonance Imaging;Measures;Mechanics;Mediating;Mediator;middle age;Morbidity - disease rate;mortality;multidisciplinary;Multimodal Imaging;National Heart, Lung, and Blood Institute;novel;older adult;Outcome Study;Participant;Pathway interactions;Pattern;Phenotype;phenotypic data;Predisposition;Prevention;Prevention strategy;Proteomics;Public Health;Pulmonary Emphysema;pulmonary function;Pulmonary Heart Disease;Pulmonary Hypertension;Race;Research;resilience;Respiratory Tract Infections;Risk;Risk Factors;Risk Marker;risk sharing;Scanning;screening;Sex Differences;Spirometry;Strategic vision;Structure;Symptoms;Systems Biology;Testing;theories;Time;Tobacco;tobacco exposure;Tobacco use;United States;Ventricular;Ventricular End-Diastolic Volumes;Viral Respiratory Tract Infection;Work;X-Ray Computed Tomography;young adult

PROJECT_TITLE: Patterns of Cardiopulmonary health across the life course

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(07)]


ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE. A current challenge in cancer research is understanding tumor heterogeneity, a major cause of resistance to chemotherapy drugs as well as metastasis development. APOBEC3A and APOBEC3B have been identified as two of the major drivers of tumor heterogeneity by promoting the deamination of cytosine to uracil on DNA and inducing genomic mutations. The goal of this proposal is to uncover the molecular mechanisms that govern APOBEC3A and APOBEC3B regulation in cancer cells.

PI_NAMEs: BUISSON, REMI  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: anti-cancer research;apoB mRNA editing catalytic subunit;Attenuated;Automobile Driving;Binding;cancer cell;cancer cell differentiation;cancer genome;cancer type;Cells;Cessation of life;chemotherapy;Clinical;Clinical Treatment;Complex;Cytosine;Data;Deamination;Development;Disease Progression;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA Sequence Alteration;Drug resistance;Event;Evolution;Family;fighting;Genetic Transcription;Genetic Variation;Genome;Genomic Instability;genomic signature;Genomics;Goals;Heterogeneity;Individual;Induced Mutation;insight;Knowledge;Lead;Location;Malignant Neoplasms;member;Molecular;Mutagenesis;Mutation;Natural Immunity;Neoplasm Metastasis;neoplastic cell;next generation sequencing;Normal Cell;Outcome;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Population;prevent;Process;Prognosis;protein complex;Proteins;Regulation;replication stress;Research;Resistance;Sampling;Signal Pathway;Signal Transduction;Single Stranded DNA Virus;Single-Stranded DNA;Site;Source;Stat2 protein;Stress;Survival Rate;System;Technology;Therapeutic;therapeutic development;tumor;tumor heterogeneity;Uracil;Virus Replication;Writing

PROJECT_TITLE: Molecular Mechanisms of APOBEC-Induced Mutagenesis in Cancer

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;HIV/AIDS;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative The University of North Carolina (UNC) Project Malawi Cancer Program proposes to establish the Malawi Cancer Outcomes Research Program (M-CORP) in collaboration with its primary partner, the University of Malawi College of Medicine (COM). M-CORP addresses high-priority needs identified by UNC, COM and other partners, to develop research expertise aligned with institutional and national goals. The proposal builds on a strong foundation and investment in breast cancer, cervical cancer and lymphoma research in Malawi, well- established collaborations, and engages pre-existing cancer outcomes research training programs at UNC to synergistically expand the global cancer research workforce.

PI_NAMEs: CHINULA, LAMECK ;FEDORIW, YURI  (contact)

PROGRAM_OFFICER_NAME: SIVARAM, SUDHA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa South of the Sahara;African;AIDS Malignancy Consortium;AIDS related cancer;anti-cancer research;Cancer Burden;cancer clinical trial;Cancer Control;career;Cervical Cancer Screening;Cessation of life;clinical translation;Clinical Trials;Collaborations;college;Country;Databases;Educational Curriculum;Ensure;Environment;Epidemiology;experience;Foundations;Funding;Generations;Grant;HIV;Human Development;improved;indexing;Institution;International;investigator training;Leadership;Lymphoma;Malaria;Malawi;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of esophagus;Malignant Neoplasms;Medicine;Mentors;multidisciplinary;National Cancer Institute;North Carolina;Outcome;Outcomes Research;Postdoctoral Fellow;Program Evaluation;programs;Research;Research Personnel;Research Priority;Research Project Grants;skills;success;Testing;Time;training opportunity;Training Programs;Tuberculosis;Universities;USAID


NIH_SPENDING_CATS: Asthma;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This research addresses the need for more personalized and comprehensive pediatric asthma management at the point of care in order to improve pediatric asthma management and outcomes. The studies will develop and evaluate a multifaceted clinical decision support system in the electronic health record that integrates patient reported data.

PI_NAMEs: ROSS, MINDY K (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 11 year old;Address;Adherence;age group;Algorithms;Area;Asthma;asthma exacerbation;asthmatic patient;Award;career;Caregivers;Caring;Child;Childhood;Childhood Asthma;Clinic Visits;Clinical;Clinical Data;clinical decision support;Clinical Decision Support Systems;clinical decision-making;Clinical Informatics;Clinical Trials;comorbidity;Complex;computerized;Data;data integration;Data Reporting;Decision Making;design;Development;Education;Electronic Health Record;Elements;Environment;Environmental Risk Factor;experience;Family;Funding;Future;General Practitioners;Goals;Grant;Guidelines;Health Services;Health system;Healthcare;Hospitalization;implementation science;improved;Individual;Informatics;informatics tool;information gathering;Information Technology;innovation;insight;Knowledge;low socioeconomic status;Manuals;Measures;medication compliance;meetings;Mentorship;Methods;Morbidity - disease rate;Outcome;Outpatients;Parents;Patient Care;Patient Outcomes Assessments;patient portal;Patients;pediatrician;Pediatrics;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;point of care;Prevention program;Process;Productivity;professor;Proxy;Psychosocial Factor;Publishing;Pulmonology;Qualitative Methods;Qualitative Research;Questionnaires;Recommendation;Reporting;Research;Risk Factors;Severities;skills;Social Environment;Socioeconomic Status;Specialist;Standardization;stressor;support tools;Symptoms;System;Target Populations;Testing;Time;tool;Training;treatment as usual;United States National Institutes of Health;uptake;usability;user-friendly;Visit;Work;Writing

PROJECT_TITLE: Patient Entered Data for Clinical Decision Support to Personalize Pediatric Asthma Management

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(JA)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Dental, Oral, and Craniofacial Disease;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The common marmoset (Callithrix jacchhus) has emerged as a critically important biomedical animal model in in a variety of study disciplines. Increased demand for marmosets in scientific research studies has been most acute in neuroscience, where the need to study cognition, behavior, and mental illness in primate models with new genomic editing and gene targeting methodologies has surged. As access to marmosets is limited, and a national strategy is needed for coordinating marmoset research populations, the proposed project will establish a marmoset coordination center that joins real-time census data on marmosets and expert marmoset neuroscientists, which together will provide information and access to animals for scientists in the broader neuroscience community.

PI_NAMEs: CONRAD, DONALD F. (contact);LEVINE, JON E;ROSS, CORINNA NICOLE

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: Acute;Adoption;Agreement;American;Animal Model;Animals;Behavior;Biology;BRAIN initiative;Breeding;Callithrix;Callithrix jacchus jacchus;Censuses;Cognition;Collaborations;Communication;Communities;Country;Data;Data Aggregation;Data Management Resources;data resource;design;Discipline;Equipment and supply inventories;Evaluation;Event;experience;Foundations;Funding;Gene Targeting;Genetic;genetic information;genetic manipulation;genetic pedigree;genome editing;Genotype;Genotype-Tissue Expression Project;Human Resources;Individual;Informatics;Infrastructure;Intake;interest;Internet;Laboratories;Letters;Manuals;Mental disorders;Methodology;Modeling;Neurosciences;Neurosciences Research;nonhuman primate;Oregon;Population;Practice Guidelines;Primates;Production;programs;Protocols documentation;Research;Research Personnel;research study;Resources;Scientist;Services;statistics;Structure;System;Time;United States;United States National Institutes of Health;Update;web portal;web site;Wisconsin

PROJECT_TITLE: Coordinating center for collaborative marmoset research


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE We have discovered and studied three novel, inter-related mechanisms relevant to severe asthma pathophysiology, including the role of: 1) β2 adrenergic receptor regulation by S-nitrosylation; 2) airway acidification; and 3) androgen signaling. Our Program will have three Projects with strong scientific and operational synergies to study these discoveries and to translate them into new therapies. Each Project will make use of five Cores, unique in our institutions, for economy of scale.

PI_NAMEs: GASTON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: LU, JINING

PROJECT_TERMS: Address;Adrenergic Agents;Affect;airway epithelium;airway inflammation;Alkalinization;Androgen Receptor;Androgens;Asthma;Basic Science;beta-2 Adrenergic Receptors;Biological Products;Biology;Biostatistics Core;Bronchoscopy;Buffers;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;Clinical Trials;Coenzyme A;cost;Data;Data Analyses;data dissemination;dehydroepiandrosterone;Disabling;disabling disease;Enzymes;Epithelial Cells;Functional disorder;Gene Expression;Goals;Health Care Costs;Human;IL17 gene;IL4 gene;In Vitro;in vivo;Indiana;Inflammation;Inhalation;innovation;Institution;Intervention;Lung;Mediating;Monitor;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;novel strategies;novel therapeutics;Obstructive Lung Diseases;Oxidoreductase;Pathway interactions;Patients;personalized medicine;Program Research Project Grants;programs;receptor expression;Receptor Signaling;Regulation;Research Project Grants;Role;S-Nitrosoglutathione;S-Nitrosothiols;Safety;Science;Signal Transduction;Specimen;synergism;therapeutic development;Translating;United States;Universities

PROJECT_TITLE: Scientific innovation for personalized severe asthma management

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP(MA)]


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Accounting;Annual Reports;Asthma;Award;Certification;Charge;Clinical;Data;Development;Education;Elements;Ensure;experimental study;Faculty;Grant;Human Resources;IACUC;Information Dissemination;innovation;Institution;Institutional Review Boards;K-Series Research Career Programs;Legal patent;Manuscripts;meetings;member;Monitor;National Heart, Lung, and Blood Institute;next generation;organizational structure;Patients;Preparation;programs;Protocols documentation;Publishing;Records;Reporting;Research Personnel;Resources;Safety;Schedule;Scientist;Series;timeline;Training;Training Programs;Travel;United States National Institutes of Health;Visit;web site;Work;Writing

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


NIH_SPENDING_CATS: Clinical Research;Hematology;Lung;Orphan Drug;Pediatric;Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Project Narrative The survival rates of stem cell transplants are improving allowing more children to be treated; as a result, more children are getting a form of lung injury called bronchiolitis obliterans as a side- effect of the transplant. In this study we will collect clinical and biological data to help figure out why children get this complication and how best to treat it. Children can’t perform some of the most helpful lung function tests used in adults because the tests require cooperation, so we will also test new methods to test lung function to identify lung injury more quickly in small children.

PI_NAMEs: DAVIES, STELLA MARGARET (contact);GOLDFARB, SAMUEL ;WOODS, JASON C

PROJECT_TERMS: 10 year old;Address;Adult;Affect;Allogenic;Anatomy;Biological;Biological Testing;biomarker identification;Biopsy;Bronchiolitis Obliterans;Bronchoalveolar Lavage Fluid;Bronchoscopy;Calendar;Child;Childhood;Clinical;Clinical Data;clinical phenotype;clinical risk;cohort;Cohort Studies;Collaborations;Collection;Complication;Data;Data Collection;Diagnosis;Diagnostic;diagnostic strategy;Disease;Early Diagnosis;emerging pathogen;Enrollment;Etiology;Evaluation;Event;exhaust;Failure;Freezing;Frequencies;Functional disorder;Funding;Future;Genetic;Guidelines;Hematopoietic Stem Cell Transplantation;Home;Image;Impairment;improved;Incidence;Inflammation;Infrastructure;Injury;innovation;Investigation;Knowledge;Lavage;Liquid substance;Lung;Lung Diseases;lung injury;Lung Transplantation;Magnetic Resonance Imaging;Maps;Marrow;Methods;Molecular;Monitor;Morbidity - disease rate;mortality;Multicenter Studies;new therapeutic target;Non-Malignant;Non-Neoplastic Hematologic and Lymphocytic Disorder;novel;novel diagnostics;novel strategies;optimal treatments;Oscillometry;Outcome;Pathologic;Pathology;Pediatric cohort;Performance;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Plasma;Policies;predictive marker;Prevention;Preventive;prospective;prospective test;Prospective, cohort study;Proteomics;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Pulmonary Pathology;Qualifying;Rare Diseases;Recovery;Regimen;Research Personnel;Resources;response;Retrospective Studies;Risk;Risk Factors;Sampling;Schedule;screening;Screening procedure;Series;Serum;Sickle Cell Anemia;side effect;Signs and Symptoms;Site;Slide;small airways disease;Spirometry;Standardization;Stem cell transplant;success;Survival Rate;Techniques;Teenagers;Testing;Thalassemia;Therapeutic;Therapeutic Agents;Therapeutically Targetable;Time;Tissues;transplant centers;Transplant Recipients;Transplantation;treatment response;United States National Institutes of Health

PROJECT_TITLE: TRANSPIRE: A Prospective Cohort Study of Lung Injury After Hematopoietic Stem Cell Transplant in Children.

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


PI_NAMEs: TWIGG, HOMER L (contact)

PROJECT_TERMS: Acceleration;Address;Area;Asthma;Basic Science;biobank;Biopsy;Blood;Blood specimen;Bronchoalveolar Lavage;Bronchoscopy;Cell Separation;Clinical;Clinical Sciences;Clinical Trials;clinically relevant;Data Coordinating Center;Databases;design;Dimethyl Sulfoxide;Disease;Ensure;Environment;experimental study;feasibility research;Future;Genomics;Goals;Human;human tissue;Imaging Techniques;In Vitro;Indiana;Infrastructure;innovation;insight;interest;Label;Lead;Link;Liquid substance;Lung;Measurement;Metadata;Nitrogen;novel strategies;Patients;Peripheral Blood Mononuclear Cell;Plasma;preservation;Prevention approach;Process;programs;Proteomics;Protocols documentation;recruit;Research;Research Personnel;Research Project Grants;Resources;RNA;Sampling;Scientist;Serum;Services;skills;Specimen;Specimen Handling;Study Subject;Time;Time Study;Tissues;Translational Research;translational scientist;translational study;Universities;Work

PROJECT_TITLE: Research Bronchoscopy and Biospecimens Core


NIH_SPENDING_CATS: Asthma;Clinical Research;Clinical Trials and Supportive Activities;Lung;Patient Safety

PI_NAMEs: CHMIEL, JAMES F (contact)

PROJECT_TERMS: Address;Adverse event;Agreement;Archives;Area;Asthma;Basic Science;bench-to-bedside translation;Biological;Biological Process;Biopsy;Biostatistics Core;Budgets;career;Clinical;Clinical Data;clinical investigation;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Collection;Communication;Conduct Clinical Trials;Consultations;Contracts;cost effective;Data;Data Analyses;Data Collection;data repository;Data Storage and Retrieval;Databases;Dedications;design;Development;Ensure;Exhalation;experience;Good Clinical Practice;healthy volunteer;Human;Human Resources;improved;Indiana;Individual;innovation;Institution;Institutional Review Boards;interest;Investigation;Laboratories;Manuscripts;material transfer agreement;Measurement;Medical;Mentors;Monitor;next generation;Nitric Oxide;Nose;operation;Participant;participant safety;Patients;performance tests;Phase;Physical condensation;Population;Preparation;Procedures;programs;Protocols documentation;Pulmonary function tests;Qualifying;Quality Control;Radiology Specialty;Records;recruit;Report (document);Research;Research Design;Research Personnel;Research Project Grants;Resources;Safety;sample collection;Sampling;Schedule;Services;Site;Source;Specimen;Study Subject;success;synergism;Testing;Therapeutic;Tissues;Training;Translations;Universities;Visit;Work

PROJECT_TITLE: Severe Asthma Clinical Studies Core


NIH_SPENDING_CATS: Asthma;Biotechnology;Lung

PI_NAMEs: DAVIS, MICHAEL D (contact)

PROJECT_TERMS: 3-Dimensional;Acute;Air;Airway Disease;airway epithelium;Asthma;asthmatic patient;Bar Codes;Biological Assay;biophysical properties;Biopsy;Bronchoscopy;cell behavior;Cell Count;Cell Culture Techniques;Cell Line;cell repository;Cell Separation;Cells;chronic respiratory disease;clinical phenotype;Collection;Cryopreservation;Cryopreserved Cell;D Cells;Disease;Doctor of Philosophy;Ensure;Epithelial Cells;Epithelium;experience;experimental study;Fibroblasts;Foundations;Functional disorder;Genotype;Goals;Gossypium;Growth;Harvest;Human;Indiana;Innate Immune System;innovation;kinase inhibitor;Label;Liquid substance;Living Donors;Lung;Lung Diseases;Maintenance;Methods;Morbidity - disease rate;mortality;Muscle Cells;muscle physiology;National Heart, Lung, and Blood Institute;pathogen;patient population;Patients;Pharmaceutical Preparations;Physiological;Play;Program Research Project Grants;programs;Protocols documentation;Recording of previous events;repository;Research Personnel;respiratory smooth muscle;response;Rho-associated kinase;Role;Sampling;Site;Smooth Muscle;Smooth Muscle Myocytes;Source;Testing;therapy development;Tissues;Training;Universities;Work

PROJECT_TITLE: Primary Human Airway Cell Culture Core


NIH_SPENDING_CATS: Asthma;Lung;Networking and Information Technology R&D (NITRD)

PI_NAMEs: ZHAO, YI  (contact)

PROJECT_TERMS: Asthma;Bioinformatics;Biometry;Biostatistics Core;Clinical Research;Collaborations;Computational Biology;Data;Data Analyses;data management;Data Reporting;design;Doctor of Philosophy;experience;Experimental Designs;experimental study;Formulation;Grant;Human Resources;Indiana;Information Dissemination;innovation;Institution;Lung;Manuscripts;meetings;Preparation;programs;Research;Research Personnel;Statistical Data Interpretation;success;System;translational study;Universities

PROJECT_TITLE: Pulmonary Biostatistics Core


NIH_SPENDING_CATS: Asthma;Clinical Research;Lung

PI_NAMEs: STAMLER, JONATHAN S. (contact)

PROJECT_TERMS: Acute;ADRBK1 gene;Adrenergic Agents;Affect;Agonist;Air Movements;airway hyperresponsiveness;airway inflammation;airway remodeling;American;arrestin 2;Arrestin Beta 1;Asthma;asthma model;asthmatic;asthmatic patient;bench to bedside;beta-2 Adrenergic Receptors;beta-arrestin;Biochemistry;biological systems;Bronchodilator Agents;Cardiac;Cell surface;Cells;Chronic;Clinical;clinically relevant;cohort;Collaborations;Complex;cost;Coupled;Cysteine;Data;desensitization;Development;Diagnosis;Drug Receptors;efficacy testing;Enzymes;Epithelial Cells;Event;Excision;Exhibits;Functional disorder;G protein coupled receptor kinase;G-Protein-Coupled Receptors;Genetic;Glutathione;Glutathione Reductase;GTP-Binding Proteins;Height;Heterotrimeric GTP-Binding Proteins;Homeostasis;Human;improved;Inhalation;inhibitor;Injury;innovation;Intervention;Kinetics;Knock-in;Link;Lung;Maintenance;Mediating;Mediator;Modeling;Molecular;Molecular Weight;mortality;mouse model;Mus;Mutant Strains Mice;Mutate;Mutation;Nitric Oxide;Nitric Oxide Synthase;Oxidation-Reduction;Oxidoreductase;Pathogenesis;Pathology;Pathway interactions;Patient Selection;patient subsets;Patients;personalized approach;Pharmaceutical Preparations;Phosphorylation;Physiology;Point Mutation;Positioning Attribute;Post-Translational Protein Processing;pre-clinical;preservation;prevent;programs;protective effect;protein function;Proteins;Publishing;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;receptor;receptor function;Receptor Signaling;Reduced Glutathione;Regulation;Resistance;Role;S-Nitrosoglutathione;S-Nitrosothiols;Sampling;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;Site;Smooth Muscle Myocytes;Sulfhydryl Compounds;synergism;System;Tachyphylaxis;Testing;Work

PROJECT_TITLE: S-nitrosylation signaling in asthma


PROJECT_TERMS: Acute;Affect;Agonist;airway epithelium;airway inflammation;alveolar lamellar body;Ammonia;Anatomy;Androgens;Asthma;asthma exacerbation;asthmatic airway;asthmatic patient;Attenuated;beta-2 Adrenergic Receptors;Bicarbonates;Buffers;Carbon Dioxide;carbonate dehydratase;Cell Culture Techniques;cell growth regulation;Cell surface;Cystic Fibrosis;cytokine;dehydroepiandrosterone;Distal;Enzymes;Epithelial Cells;Epithelium;Exhalation;experience;falls;Functional disorder;genetic regulatory protein;Glucocorticoids;Glutaminase;Health;Human;IL17 gene;IL6 gene;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inhalation;injured airway;innovation;Interleukin-13;Interleukin-4;Kidney;Lactate Dehydrogenase;Liquid substance;Location;Maps;Measures;Membrane;Metabolism;novel strategies;Oxidases;Oxidoreductase;Patients;personalized approach;Production;protein expression;Proteins;Protons;Regulation;Respiratory Tract Infections;response;S-Nitrosoglutathione;Surface;Testing;Tubular formation;vacuolar H+-ATPase;Variant;Viral;voltage

PROJECT_TITLE: Airway pH regulation in asthma


NIH_SPENDING_CATS: Asthma;Clinical Research;Genetics;Lung

PI_NAMEs: LAHM, TIM  (contact)

PROJECT_TERMS: Adrenal Cortex Hormones;airway epithelium;airway obstruction;Androgen Receptor;Androgen Therapy;Androgens;Asthma;asthmatic;asthmatic patient;Attenuated;Biology;cell injury;Characteristics;Clinical;clinically relevant;cohort;Cross-Over Trials;cytokine;Data;dehydroepiandrosterone;Dehydroepiandrosterone Sulfate;Disease;Disproportionately impacts women;Double-Blind Method;Drug Kinetics;Enzymes;Epithelial Cells;Exhalation;Exhibits;experience;Gene Expression;Genes;Genetic Variation;Genotype;Gonadal Steroid Hormones;Hormones;Human;Hydroxysteroid Dehydrogenases;improved;Inflammation;Inflammation Mediators;Inflammatory;innovation;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-6;Knowledge;Link;Lung Diseases;male;Mediating;men;Messenger RNA;Nitric Oxide;novel;Outcome;Pathway interactions;patient population;Patients;Peripheral;Pilot Projects;Placebo Control;Plasma;Population;Positioning Attribute;precision medicine;Prevalence;programs;protein expression;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Randomized;receptor expression;Regulation;Research;respiratory smooth muscle;response;Role;S-Nitrosothiols;Serum;sex;sexual dimorphism;Signal Transduction;Smooth Muscle Myocytes;Symptoms;Testing;Testosterone;Therapeutically Targetable;Tissues;treatment response;United States National Institutes of Health;Variant;Woman;women patients;women's treatment

PROJECT_TITLE: Androgen signaling in asthma


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: Narrative. Many adult behavioral patterns reflect experiences that occur when the individual is young, yet we have little mechanistic information about what happens to mediate this observation. Without addressing this gap, we risk missing significant opportunities to enhance positive or remediate adverse neurodevelopmental effects of experience. Here, we begin to fill this gap using a combination of epigenetic and molecular measures and manipulations of juvenile experience in males and females.

PI_NAMEs: LONDON, SARAH E (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: Acceleration;Acetylation;Acute;Address;Adolescent;Adult;Adult women;Adverse event;Age;Animal Experimentation;Area;Auditory;Behavior;Behavioral;Behavioral Mechanisms;behavioral outcome;Binding;Biological Assay;Biology;Birds;Brain;Cell Physiology;Cellular Structures;ChIP-seq;Chromatin;Data;design;Development;Dissection;Epigenetic Process;experience;Female;FRAP1 gene;Genomics;Goals;Hearing;Histone Acetylation;Histone H3;Histones;Human;in vivo;Individual;insight;Lead;Life;Link;male;Measures;Mediating;Mediator;Methodology;Methods;Methylation;Modeling;Molecular;neural circuit;neural initiation;neurobiological mechanism;Neurobiology;neurodevelopmental effect;Neuronal Plasticity;Nucleic Acid Regulatory Sequences;Outcome;Output;Partner in relationship;Pattern;Phase;Population;Positioning Attribute;preference;Process;programs;Prosencephalon;Proteins;Publishing;remediation;Research;response;Risk;RNA;Role;Sensory;Services;sex;Sex Differences;Signal Transduction;Social Behavior;Songbirds;Structure;System;Testing;Therapeutic;transcription factor;Transcriptional Regulation;Translations;tutoring;Work;zebra finch

PROJECT_TITLE: Linking Juvenile Experiences with Adult Patterns of Behavior

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Asthma exacerbations are the most serious expression of the disease, and despite available therapies, asthma exacerbations remain common and lead to substantial morbidity. In this proposal, we are using lung biopsies from asthmatic volunteer subjects and experimental self-limited models of asthma exacerbation to identify natural pro-resolving mediators and mechanisms. By understanding how the healthy lung restores homeostasis, we can better understand inflammatory diseases, such as asthma, and design novel rational therapeutic strategies that quicken the resolution of asthma exacerbations.

PI_NAMEs: LEVY, BRUCE D (contact)

PROJECT_TERMS: Acute;Adverse effects;Agonist;airway hyperresponsiveness;airway inflammation;Allergic;Anabolism;Anti-Inflammatory Agents;Arachidonic Acids;Asthma;asthma exacerbation;asthma model;asthmatic;asthmatic airway;Biological Products;Biopsy;candidate identification;CD59 Antigen;Cell Communication;Cell membrane;cell type;Cells;cellular transduction;Chronic;Chronic Obstructive Pulmonary Disease;cysteinyl-leukotriene;Dependence;design;Disease;Docosahexaenoic Acids;Dose;Drug Design;Enzymes;eosinophil;Epithelial Cells;Epithelium;Essential Fatty Acids;Experimental Models;experimental study;Family;Fatty Acids;Funding;Gene Expression;Generations;granulocyte;Head;Health;high dimensionality;Homeostasis;Human;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Knowledge;Laboratories;Leukocytes;lipid mediator;Lipids;Lipoxins;Lung;Macrophage;Measures;Mediator;Modeling;Modification;Molecular;molecular imaging;Morbidity - disease rate;mouse model;Mus;novel;Pathway interactions;Pharmaceutical Preparations;Play;pre-clinical;prevent;Process;Production;programs;Publishing;Pulmonary Inflammation;receptor;Regulation;Resolution;Respiratory Mucosa;response;Role;Severities;Signal Transduction;Sorting;spatiotemporal;stem;Stimulus;Structure of parenchyma of lung;Testing;Therapeutic;Thinking;Tissues;translation to humans;Translations;Validation;volunteer;Work

PROJECT_TITLE: Specialized Pro-Resolving Mediators in Asthma

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The surge in overdose deaths in the United States, primarily due to non-medical fentanyl use, has prompted the exploration of alternative strategies to increase the uptake of buprenorphine, a highly effective medication for opioid use disorder (OUD). Low Dose Initiation (LDI) protocols have emerged as a promising approach, gradually introducing small amounts of buprenorphine to minimize the risk of precipitated withdrawal, though successful initiation using LDI protocols in the outpatient setting remains low. This research proposal aims to address knowledge gaps and enhance LDI protocols through the development of an Enhanced LDI program, with the goal of increasing buprenorphine uptake among individuals with OUD using fentanyl and reducing overdose deaths.

PI_NAMEs: SUEN, LESLIE W. (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Affinity;analog;behavior change wheel;Behavior Therapy;Behavioral;Binding;Buprenorphine;career;career development;Cessation of life;Clinic;Counseling;Data;Data Sources;Dedications;design;Development;Development Plans;diaries;Dose;Drug Screening;Educational Materials;effectiveness evaluation;Electronic Health Record;Evaluation;experience;Fentanyl;fentanyl overdose;fentanyl use;fentanyl use disorder;Focus Groups;Foundations;Fright;Funding;Future;Goals;Health system;Healthcare;implementation framework;implementation science;improved;Incentives;Individual;innovation;Intervention;Interview;Knowledge;medication for opioid use disorder;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Modeling;mortality;National Institute of Drug Abuse;novel;Opioid;Opioid Receptor;opioid use disorder;Outcome;Outpatients;overdose death;Overdose reduction;Participant;patient tolerability;Patients;Persons;Pharmaceutical Preparations;Pharmacists;pharmacologic;Primary Care;programs;Property;Protocols documentation;Randomized;randomized trial;Randomized, Controlled Trials;Research;Research Methodology;Research Personnel;Research Proposals;retention rate;Risk;risk minimization;San Francisco;skill acquisition;skills;standard care;Statistical Data Interpretation;Surveys;Symptoms;System;Telephone;Testing;Therapeutic;therapy development;Training;Treatment outcome;trial design;United States;United States National Institutes of Health;uptake;Urine;Withdrawal;Work

PROJECT_TITLE: Enhancing buprenorphine low dose initiation (COPILOT)

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hematology;Lung;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Pediatric;Prevention;Rare Diseases;Sickle Cell Disease

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE Acute chest syndrome (ACS) is a common respiratory complication of sickle cell disease (SCD). It results in irreversible lung damage, can be prevented by standard of care practices such as incentive spirometry and appropriate opioid orders, yet adherence to guidelines is suboptimal. This research will investigate the barriers and enablers of implementing best practices by SCD providers in a vulnerable, predominantly low-income pediatric SCD population in New York. This information will inform the development of a clinical decision support system (CDSS) and subsequent pilot study in the context of a hybrid effectiveness-implementation study design.

PI_NAMEs: MORRONE, KERRY  (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: acute chest syndrome;Acute pain management;Address;Adherence;Admission activity;Adoption;Affect;African;Algorithms;Atelectasis;Attitude;Award;Behavior;Benchmarking;Bioinformatics;Bronchodilator Agents;career;Caring;Cessation of life;Chest Pain;Child;Childhood;Chronic;Chronic Disease;Clinical;Clinical Decision Support Systems;Clinical Research;cohort;college;Complication;Computer Simulation;Computer software;Computers;Conduct Clinical Trials;Data;Data Analyses;Data Collection;Decision Making;Department chair;design;Development;Disease Management;Documentation;Education;Educational Status;Effectiveness;effectiveness/implementation study;effectiveness/implementation trial;efficacy evaluation;Electronic Health Record;Elements;Ensure;Environment;Epidemiology;Ethnic Origin;Evaluation;Event;Face;feasibility testing;Feedback;Funding;Funding Agency;Future;Goals;Guideline Adherence;Guidelines;Health;Health Personnel;Health Services Research;Health system;Healthcare Systems;Hematology;Hemolytic Anemia;Hispanic;Hospitalization;Hybrids;Hydration status;Hypoventilation;Hypoxemia;Hypoxia;Image;implementation barriers;implementation evaluation;implementation framework;implementation outcomes;Implementation readiness;implementation science;improved;improved outcome;Incentives;Individual;Inpatients;Institution;Intervention;Interview;Learning;life span;Low income;Lung;lung injury;Maintenance;Manuscripts;Master of Science;Medical;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;Motivation;Multicenter Trials;National Heart, Lung, and Blood Institute;New York;New York City;Nursing Staff;Oncology;Opioid;Organ;Outcome;Pain;Participant;Patients;Pediatric Hematologist;Pediatric Hospitals;Pediatric Nursing;pediatrician;Pediatrics;Perception;Pharmacists;Physicians;Pilot Projects;Population;Preparation;prevent;Preventive;primary outcome;Process;Production;Provider;provider adherence;Publications;Qualitative Methods;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Design;Research Methodology;Research Personnel;Resources;respiratory;Respiratory distress;Respiratory Signs and Symptoms;Risk Factors;scale up;secondary outcome;Services;Sickle Cell Anemia;skills;Societies;software systems;Spirometry;standard of care;Standardization;Statistical Methods;statistics;Structure;Surveys;symposium;System;Testing;Time;tool;Training;trial design;United States;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;uptake;usability;user centered design;Work;Youth

PROJECT_TITLE: Reducing Morbidity in Sickle Cell Disease-Prevent Acute Chest Syndrome system (PACSystem) pilot study

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: CHARLESTON

ORG_NAME: RALPH H JOHNSON VA MEDICAL CENTER

ORG_STATE: SC

PHR: Weight loss interventions for neurologically health individuals have established benefits for improving physical and psychosocial function. We believe that Veterans who have had a stroke would realize similar benefits and that the effects would be enhanced with concurrent exercise training. We will study the effects of a 15-week lifestyle management program to determine if it can effectively improve some of the physical and psychosocial problems common in Veterans who have had a stroke.

PI_NAMEs: GREGORY, CHRIS  (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Address;Adjuvant;age related decline;Body Weight decreased;Caloric Restriction;cardiometabolic risk;cardiovascular risk factor;Caring;catalyst;Clinical;clinically significant;cohort;Communities;comparison control;Data;design;Development;Diet;diet and exercise;disability;effective therapy;Effectiveness;Enrollment;Environment;Equipment and supply inventories;evidence base;Evidence based intervention;Exercise;exercise training;experimental study;Foundations;functional decline;functional improvement;functional outcomes;Future;Goals;Guidelines;Health;health related quality of life;Impairment;improved;improved mobility;improved outcome;Individual;Institutionalization;interdisciplinary approach;Life Style;Measures;Mobility decline;Monitor;Moods;mortality;Motor;Neurologic;obese patients;obese person;Obesity;obesity management;Outcome;Overweight;Patients;Personal Satisfaction;Positioning Attribute;post stroke;programs;Provider;psychosocial;psychosocial outcome;Quality of life;Randomized;Recommendation;Recovery;Rehabilitation therapy;remediation;Research;Risk;Risk Factors;Risk Reduction;self esteem;Stroke;stroke recovery;stroke rehabilitation;stroke survivor;synergism;Testing;Time;Veterans;Waiting Lists;Walking;Weight;weight loss intervention;Weight maintenance regimen;Work

PROJECT_TITLE: Enhancing Mobility and Psychosocial function in Obese Veterans following stroke via Weight loss and ExeRcise (EMPOWER)

STUDY_SECTION_NAME: Musculoskeletal Health & Function[RRD2]


FUNDING_MECHANISM: OTHERS

ORG_NAME: PORTLAND VA MEDICAL CENTER

PHR: Our recently completed clinical trial confirms that the rates of survival and of ototoxicity are high in VA cancer patients treated with cisplatin. We found that ototoxic hearing loss, when identified, is acted on by these patients and their oncology teams. Unfortunately, we currently cannot predict which patients will experience ototoxicity. Patients and their doctors also generally lack awareness of ototoxicity, which could prompt intervention to address its many negative health and psychosocial consequences. This research program is designed to fill these gaps in knowledge and clinical care to optimize post-treatment quality of life for the ~10,000 Veterans a year who receive ototoxic chemotherapies. We will test hypotheses developed in animal studies for how tinnitus and speech understanding problems develop in humans. We will refine our tools to forecast an individual patient’s risk for ototoxicity prior to treatment, including through genetic association studies. Additionally, we will partner with patients, oncology teams, and industry to improve access to and uptake of ototoxicity management.

PI_NAMEs: KONRAD-MARTIN, DAWN L (contact)

PROJECT_TERMS: Acoustic Nerve;acoustic reflex;Acquired Deafness;Address;Adult;Adverse effects;Aftercare;Age;Aging;Animal Model;Animals;Antineoplastic Agents;Audiology;Auditory;Auditory area;Auditory Brainstem Responses;auditory pathway;aural rehabilitation;Awareness;barrier to care;Behavioral;Blood Glucose;blood glucose regulation;Blood specimen;Brain Stem;Cancer Patient;Cancer Survivor;cancer therapy;Carboplatin;career;Caring;chemoradiation;chemotherapy;Chronic;Cisplatin;Clinical;clinical care;clinical practice;Clinical Trials;Cochlea;cognitive control;cognitive function;Compensation;cost;Counseling;Cues;Data;Decision Making;design;Development;Devices;Diabetes Mellitus;diabetic;Diagnostic Procedure;disability;Effectiveness;emotional distress;evidence base;Evoked Potentials;experience;Functional disorder;Funding;Future;Genes;Genetic;genetic association;Goals;Growth;Hair Cells;Health;Healthcare;Hearing;hearing impairment;Hearing Tests;high risk;Human;Impairment;Improve Access;improved;Individual;individual patient;Industry;Injury;innovation;Insulin;Intervention;Knowledge;Lesion;Lived experience;Malignant Neoplasms;Mathematics;Measurement;Measures;Mental Depression;Methods;Military Personnel;military service;model development;Modeling;Modification;neoplasm registry;Nerve Degeneration;neural;Neural Conduction;Neuronal Plasticity;noise exposure;normal aging;Oncologist;Oncology;otoacoustic emission;otoprotectant;ototoxicity;Outcome;Outer Hair Cells;oxaliplatin;Patient Monitoring;patient oriented;Patient risk;patient variability;Patients;pharmacologic;Pharmacologic Substance;Pharmacotherapy;Physiological;Pilot Projects;Platinum;population based;predictive modeling;Predisposition;prevent;Preventive healthcare;Productivity;prognostic model;programs;prospective;Protocols documentation;Provider;psychological distress;psychosocial;Quality of life;Questionnaires;Randomized, Controlled Trials;Recommendation;Recording of previous events;Rehabilitation therapy;Research;Research Activity;Research Priority;Resource Allocation;Resources;risk stratification;Scientist;screening;self esteem;Sensory;Service delivery model;Service provision;Services;Severity of illness;Shapes;side effect;Single Nucleotide Polymorphism;Site;Sleeplessness;social engagement;Speech;speech in noise;Surveys;Survival Rate;survivorship;Symptoms;System;Techniques;Technology;telehealth;Testing;therapy development;Thinking;Time;Tinnitus;tool;TPMT gene;treatment as usual;treatment planning;uptake;Veterans;Withdrawal;Work;Workload;Workplace;young adult

PROJECT_TITLE: Research Career Scientist

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Atherosclerosis;Genetics

ORG_CITY: DALLAS

ORG_DEPT: GENETICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE  HMG CoA reductase (HMGCR) is the molecular target of cholesterol lowering statin drugs, and a key regulatory enzyme of the cholesterol biosynthetic pathway which is subjected to feedback regulation by sterol and nonsterol isoprenoid end products that act to induce its endoplasmic reticulum (ER)–associated degradation (ERAD). I have shown that the 1,1-bisphosphonate ester SRP3042 mimics sterols in inducing HMGCR ERAD without disrupting transcriptional feedback mechanisms, and a photoactivatable form specifically crosslinks HMGCR. This proposal aims to determine the sterol- sensing mechanisms through which HMGCR ERAD is initiated to determine whether SRP3042 induced HMGCR ERAD is a viable strategy for overcoming statin-resistance, will identify the molecular target of LY295427, and elucidate the molecular mechanisms by which LY295427 reverses the 25- hyroxycholesterol mediated transcriptional activation and post-translational regulation of lipid homeostasis.

PI_NAMEs: FAULKNER, REBECCA ANN (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: 25-hydroxycholesterol;Acceleration;Acyl Coenzyme A;Amphotericin B;Atherosclerosis;Binding;Binding Proteins;Biochemical;career;Cells;Chemistry;Cholesterol;Complement;Complex;Coupled;Coupling;CRISPR/Cas technology;crosslink;Cryoelectron Microscopy;Data;Development;Dimethylallyltranstransferase;Disease;drug efficacy;Endoplasmic Reticulum;Ensure;Enzymes;Event;Feedback;Future;Genetic Transcription;Genomics;geranylgeranyl pyrophosphate;Goals;Hepatic;HMGB1 gene;Homeostasis;Hydroxymethylglutaryl-CoA reductase;hypercholesterolemia;Immunoprecipitation;Incidence;inhibitor;innovation;insight;Integral Membrane Protein;interdisciplinary approach;interest;isoprenoid;Knock-in;Knock-in Mouse;Knock-out;LDL Cholesterol Lipoproteins;lipid metabolism;Lipids;Liver;Low Density Lipoprotein Receptor;Low-Density Lipoproteins;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Mentors;Methylation;mevalonate;Molecular;Molecular Conformation;Molecular Genetics;Molecular Target;Monitor;multicatalytic endopeptidase complex;Mus;Mutation;novel;novel strategies;Parents;Pathway interactions;Pharmaceutical Preparations;Phase;Photoaffinity Labels;Plasma;Play;Post-Translational Regulation;prevent;Prevention therapy;professor;protein activation;Protein Family;Proteins;Proteolysis;Reaction;Regulation;Regulatory Element;Reporting;Research;Resistance;Scientist;Small Interfering RNA;SR-45023A;Sterol O-Acyltransferase;Sterols;synthetic enzyme;System;Techniques;Therapeutic;Training;transcription factor;Transcriptional Activation;Transcriptional Regulation;Ubiquitination;Vitamin K 2;Wild Type Mouse

PROJECT_TITLE: Elucidating the sterol-sensing mechanisms that regulate lipid metabolism.

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-8 (MK)]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative: (relevance to public health) This project studies a molecular pathway that, based on studies in rodents and other model organisms, becomes activated and contributes to outcomes in multiple scenarios and axonal injury and stress, nerve damage, chemotherapy, traumatic brain injury, excitotoxicity and models of ALS and Alzheimer's Disease. By understanding the molecular mechanisms of the pathway's activation and downstream actions, which include how it activates the immune system, the findings from this project will guide future therapeutic strategies to promote beneficial outcomes and/or inhibit deleterious outcomes of nervous system damage.

PI_NAMEs: CADIGAN, KENNETH M;COLLINS, CATHERINE A (contact)

PROJECT_TERMS: Address;Adhesives;Alzheimer's Disease;Axon;axon growth;axon injury;axon regeneration;Axonal Transport;Axotomy;Behavior;biological adaptation to stress;Brain;Categories;Cell Death;cell type;Cells;chemotherapy;Cytoskeleton;disease model;Drosophila genus;Drosophila melanogaster;Excision;excitotoxicity;experimental study;extracellular;Future;Genes;Goals;Immune;Immune response;Immune system;Impairment;Individual;injured;Injury;insight;interest;lens;Mammals;Microglia;Mitogen-Activated Protein Kinases;model organism;Modeling;Molecular;Motor Neurons;mouse model;Mus;Mutation;nerve damage;nerve injury;Nervous System;Nervous System Trauma;neurodegenerative dementia;Neurodegenerative Disorders;Neuromuscular Junction;neuron component;neuron loss;neuronal circuitry;Neuronal Injury;Neurons;Neuropathy;neurotransmission;Organism;Outcome;painful neuropathy;Pathway interactions;Peripheral;Peripheral nerve injury;Pharmaceutical Preparations;Phenotype;Phosphotransferases;Presynaptic Terminals;Process;Public Health;recruit;regenerative;Regulation;repaired;response;restraint;RiboTag;Rodent;Signal Induction;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Spinal Cord;Stress;stroke model;Synapses;TBI treatment;Technology;Testing;Therapeutic;therapeutic target;Work

PROJECT_TITLE: Regenerative and degenerative responses to axonal injury


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases

ORG_NAME: GREATER LOS ANGELES VETERANS RESEARCH AND EDUCATION FOUNDATION

PHR: Project Narrative Successful completion of this project will substantiate a preclinical rationale for targeting circular RNA-derived proteins which activate known drivers of glioblastoma for trials in patients. Additionally, this study will provide information as to the operative mechanisms resulting in hyperactive receptor tyrosine kinase signaling leading to escape from current targeted therapies for glioblastoma management.

PI_NAMEs: GERA, JOSEPH F (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Adult;Affect;analog;autocrine;Automobile Driving;Biochemical;Biology;cancer biomarkers;cancer diagnosis;Cell Death;cell growth;Cell secretion;Cells;Characteristics;Chemicals;circular RNA;Clinical;Cyclic AMP-Dependent Protein Kinases;Data;Diagnostic;Disease Marker;Epidermal Growth Factor Receptor;epidermal growth factor receptor VIII;Evaluation;Event;experimental study;Gene Expression;Genes;Genetic;Glioblastoma;Growth;Human;Hyperactivity;In Vitro;in vivo;inhibitor;Internal Ribosome Entry Site;Invaded;Malignant - descriptor;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Messenger RNA;Molecular;Motility;Neoplasms;neoplastic cell;Neurons;novel;Oncogenic;Operative Surgical Procedures;overexpression;paracrine;patient derived xenograft model;Patients;pharmacologic;Phenotype;pre-clinical;preclinical development;Proliferating;Property;Protein Biosynthesis;Proteins;receptor;Receptor Protein-Tyrosine Kinases;Refractory;Regulation;Regulatory Pathway;Resected;RNA;Role;Signal Transduction;small molecule inhibitor;spatiotemporal;standard of care;Structure-Activity Relationship;targeted treatment;temozolomide;Testing;Therapeutic;therapeutic target;Tissues;transcriptome;Translating;Translation Initiation;Translations;tumor;tumor growth;Tumorigenicity;Variant

PROJECT_TITLE: Targeting circRNA translation in glioblastoma

STUDY_SECTION: MCTB

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics B Study Section[MCTB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Skin Cancer

PHR: PROJECT NARRATIVE There is an urgent need to identify patients with stage II-III melanoma who have been cured by surgery, are not likely to recur, and should not receive further treatment. The immune system limits cancer progression but to date no biomarkers are available to define low risk groups. We further validate previously developed immune biomarkers and combine them to create a composite biosignature defining patients who can safely be spared the expense and toxicity of therapy.

PI_NAMEs: CHANG, RUI ;SAENGER, YVONNE MARGARET (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Academic Medical Centers;Adjuvant;Adjuvant Study;Adjuvant Therapy;artificial intelligence method;Bayesian Network;Biological Markers;biomarker validation;biosignature;British Columbia;Calibration;Cd68;CD8B1 gene;Cells;Cessation of life;Clinical;clinical application;clinical care;Clinical Data;Clinical Protocols;cohort;Computer software;Computer Vision Systems;computerized tools;cost;Cutaneous;Cutaneous Melanoma;Data;Development;digital;digital imaging;digital pathology;disorder risk;DNA Sequence Alteration;Elements;Exposure to;Fluorescence;follow-up;Formalin;Gene Expression;Genes;Genomic approach;genomic data;Genomics;Growth;Health Care Costs;Health system;Hematoxylin and Eosin Staining Method;high risk;Image;Image Analysis;Immune;immune cell infiltrate;Immune system;Immunity;Immunologic Markers;Immunologic Surveillance;improved;Individual;Institution;Interferons;Interobserver Variability;Location;Machine Learning;machine learning model;Macrophage;Malignant Neoplasms;Measurement;Medical center;medical schools;Melanoma;Melanoma patient;Melanoma Tumor;Messenger RNA;Methods;Molecular;Morphology;mortality risk;multi-scale modeling;nano-string;network models;Nuclear;Operative Surgical Procedures;Outcome;Paraffin Embedding;Pathologist;Pathology;Pathway Analysis;Patient Care;Patient Triage;Patients;Phenotype;Positioning Attribute;Prognosis;Prognostic Marker;prospective;Public Health;Publishing;quantitative imaging;Recurrence;Recurrent disease;Reproducibility;Retrospective Studies;Risk;RNA;Role;Roswell Park Cancer Institute;Sampling;Selection Bias;Skin;Spatial Distribution;Speed;Staging;Stains;Standardization;Systems Biology;T-Lymphocyte;Technology;Testing;Tissue Embedding;Tissues;Toxic effect;transcriptomic profiling;transcriptomics;Treatment-related toxicity;tumor;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;Universities;Update

PROJECT_TITLE: Applying pathomics to establish a biosignature for aggressive skin melanoma


ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: The prevalence of overweight/obesity is estimated to be 78% among U.S. Veterans, substantially higher than in the general population. Given the association between obesity and comorbid medical conditions, increased disability levels, and reduced quality of life, this represents a significant health concern. As such, it is clear that new strategies for obesity management are needed. One possible strategy is targeting eating behaviors. A key obstacle in understanding how to best accomplish this, however, is our poor understanding of sex-based differences in eating behaviors, which are consistently observed. The goal of this proposal, therefore, is to better understand sex-based differences in the neurobiology of hedonic eating behaviors. By focusing on this knowledge gap, this proposal addresses both an important health issue affecting the vast majority of Veterans, and specifically seeks to improve the health of women Veterans, who are the fastest-growing population of Veterans.

PI_NAMEs: LEGGET, KRISTINA T (contact)

PROJECT_TERMS: Address;Affect;Behavior;Brain region;comorbidity;Cues;Desire for food;Diet;disability;Disparity;Eating;Eating Behavior;Eating Disorders;Energy Intake;Estradiol;Fasting;Food;food consumption;General Population;Goals;Gonadal Hormones;Health;Healthcare;Healthy Eating;hedonic;Hormones;Hunger;improved;Insula of Reil;Intake;Investigation;Knowledge;Life;Luteal Phase;Measures;Medical;men;Menstrual cycle;Methods;military veteran;Morbid Obesity;MRI Scans;Neurobiology;Neurons;novel;Nucleus Accumbens;Obesity;obesity management;obesity prevention;Overweight;Phase;Physical activity;pressure;Prevalence;Process;Progesterone;proliferative phase Menstrual cycle;Quality of life;Reporting;response;reward processing;Rewards;Role;Sample Size;Sampling;Satiation;Scanning;sex;Sex Differences;social;therapeutic target;therapy development;Translating;Veterans;weight maintenance;Weight maintenance regimen;Woman;women versus men;Women's Health

PROJECT_TITLE: Sex Effects on the Neurobiology of Eating Behaviors in Veterans with Overweight/Obesity


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: The number of cardiovascular surgeons conducting research is diminishing, and a vital need exists to provide quality research training for aspiring academic cardiovascular surgeons. This formal training program addresses this shortage by providing for collaboration between basic scientists and clinical faculty to train surgery residents in basic, translational or clinical research to produce the next generation of highly trained cardiothoracic surgeon-scientists devoted to understanding the pathogenesis and treatment of cardiovascular injury and disease.

PI_NAMEs: KRON, IRVING L.;LAUBACH, VICTOR E (contact);ROESER, MARK

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Cardiovascular Surgical Procedures;Training Programs

PROJECT_TITLE: Cardiovascular Surgery Training Program

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


ORG_CITY: Nashville

ORG_DEPT: BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: The Cellular, Biochemical, and Molecular Sciences (CBMS) Training Program provides a highly enriching, rigorous, interdisciplinary environment to train the next generation of scientists to identify and attack critical, basic-science questions in medicine and biology. Our established cadre of preceptors and programmatic activities foster trainee development leading to new approaches and technologies to address critical challenges at the cutting edge of biomedical science.

PI_NAMEs: FRIEDMAN, KATHERINE LOUISE;GRAHAM, TODD R;PATTON, JAMES G. (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Cellular, Biochemical and Molecular Sciences Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - B[TWD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: NARRATIVE The proposed study will incorporate new neuropathologic indices, neuroimaging, and promising blood biomarkers of AD and neurodegeneration and apply a highly innovative statistical approach to precisely identify the profile of healthy cognitive aging. Building on prior work, we will first identify healthy cognitive aging among autopsied persons with detailed pathologic data; importantly, we will then extend this approach to living persons. Finally, we will integrate new biomarker and ante-mortem neuroimaging data with our established cognitive age metric to develop and validate accurate criteria for prediction of incident MCI and Alzheimer’s dementia; thus, the proposed study offers a rare opportunity to identify healthy aging and facilitate approaches to identify individuals at high risk of developing cognitive impairment.

PI_NAMEs: BOYLE, PATRICIA A (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-Protein;Autopsy;Behavior;Biological Markers;biracial;Blood;Blood Vessels;blood-based biomarker;Cessation of life;Chicago;clinical practice;Clinical Trials Design;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive system;Data;Data Set;disorder prevention;Future;Glial Fibrillary Acidic Protein;Goals;Health;healthy aging;high risk;Impaired cognition;improved;in vivo;indexing;Individual;innovation;late life;Link;Memory;Microglia;Microvascular Dysfunction;Modeling;Nerve Degeneration;neuroimaging;neuropathology;novel strategies;Outcome;Pathologic;Pathologic Processes;Pathology;Persons;population based;Prevention;prognostic indicator;programs;prospective;Public Health;Publications;religious order study;Reporting;Research;Residual state;Risk;Sampling;Scientific Advances and Accomplishments;Specific qualifier value;Structure;tau-1;Time;Translating;Variant;Work

PROJECT_TITLE: Characterizing the Behavior Profile of Healthy Cognitive Aging

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-L(90)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROGAM NARRATIVE We show that AAV-expressed entry inhibitors can establish functional cures in rhesus macaques. We will make these functional cures safer, more consistent, and more robust, use these cures to study “kick-and- kill” eradication strategies, and ask whether a “kick” is necessary if the “kill” is potent and sustained.

PI_NAMEs: FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: ZHOU, YAN

PROJECT_TERMS: adeno-associated viral vector;Antibodies;antiretroviral therapy;Binding;Biological Assay;Cells;Clinic Visits;Data;Dependovirus;Disease remission;Environment;Epitopes;experience;Goals;Healthcare;HIV;HIV-1;Human;Immune response;Immunologics;improved;Infection;inhibitor;insight;Integrase Inhibitors;Laboratories;Macaca;Macaca mulatta;Measurement;Mediating;Mus;Muscle;neutralizing antibody;nonhuman primate;Pharmaceutical Preparations;prevent;Primates;Process;programs;Property;rate of change;Research;Resistance;RNA;Safety;Series;simian human immunodeficiency virus;SIV;Tail;Technology;Testing;Therapeutic;therapeutic transgene;Time;tool;transgene expression;Transgenes;Universities;Variant;vector;Viral Proteins;Viral reservoir;Viral Vector;Virion;Virus;Virus Replication;Wisconsin;Work

PROJECT_TITLE: An AAV-mediated functional cure and its impact on the reservoir


ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative The overarching goal of the Emory R38 program is to leverage the rich infrastructure and the interdisciplinary research environment at Emory to provide clinical and translational research training for resident physicians in the field of infectious diseases, allergy, microbiology, and immunology. The long-term goal is to expand the pool of physician scientists engaged in these areas of research. This goal will be operationalized through the development and sustained support of a structured research training program that offers an in-depth training in the fundamentals of clinical and translational research; fostering an Emory R38 specific mentoring program that is tailored to the training needs of resident physicians; and building a systematic approach for identifying and recruiting a diverse cohort of resident physicians into the program.

PI_NAMEs: OFOTOKUN, IGHOVWERHA  (contact);ROUPHAEL, NADINE GEORGES

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Address;American;Animals;Area;Biomedical Research;Board Certification;career;career development;Clinical;Clinical and Translational Science Awards;clinical care;Clinical Ethics;Clinical Research;clinical training;Clinical Trials;cohort;Communicable Diseases;Communication;COVID-19 pandemic;Creativeness;Decision Making;Development;Diagnostic;Disease Management;education research;Educational Curriculum;Educational workshop;Eligibility Determination;Environment;Evaluation;expectation;experience;Fellowship;flexibility;Fostering;fundamental research;Funding;Funding Opportunities;Future;Goals;Grant;Health;health care quality;health equity;Hypersensitivity;Immunology;improved;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;interest;Internal Medicine;Leadership;Mediation;Medical Education;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Microbiology;multidisciplinary;National Institute of Allergy and Infectious Disease;National Research Service Awards;next generation;Occupations;Outcome;pandemic response;Physician's Role;Physicians;Play;Positioning Attribute;Process;Program Development;programs;Protocols documentation;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;Residencies;Resources;response;Role;Rotation;Schedule;Scientist;senior faculty;Senior Scientist;skill acquisition;skills;Specialty Boards;Structure;success;Supervision;Therapeutic;Time;Time Management;TNFSF15 gene;Training;Training and Infrastructure;Training Programs;Translational Research;Translations;Underrepresented Minority;United States National Institutes of Health;Universities;Vaccines;vaccinology

PROJECT_TITLE: Emory R38 Research Training Program


NIH_SPENDING_CATS: HIV/AIDS

PROJECT_TERMS: adeno-associated viral vector;animal care;Antibodies;antiretroviral therapy;Cells;Collaborations;Committee Members;Communication;cost;decay acceleration;Decision Making;Dependovirus;Disease remission;Ensure;experience;Experimental Designs;experimental study;Financial Support;Goals;Immune system;Individual;inhibitor;Logistics;Macaca;Macaca mulatta;Manuscripts;Mediating;meetings;member;National Institute of Allergy and Infectious Disease;nonhuman primate;operation;Persons;Prevention;Primates;programs;Publications;Reporting;Research Personnel;Resources;Role;simian human immunodeficiency virus;Site;SIV;symposium;United States National Institutes of Health;Virus Diseases

PROJECT_TITLE: Core A: Administrative Core


PROJECT_TERMS: adeno-associated viral vector;Adverse event;adverse event monitoring;Animals;Antibodies;antibody-dependent cell cytotoxicity;Biological Assay;Board Certification;Capsid;cohort;Communication;Complement;Dependovirus;Diagnostic;Disease remission;DNA;Ensure;Exclusion;Experimental Designs;Goals;Healthcare;histological studies;Histology;Human;Human Resources;Immunologics;Immunology;improved;Individual;Infection;insight;Intervention;Laboratories;Learning;Macaca;Macaca mulatta;Massachusetts;Measures;Mediating;Monitor;Mus;neutralizing antibody;nonhuman primate;Pathologist;Pathology;Personal Satisfaction;Pharmaceutical Preparations;Primates;Procedures;programs;promoter;Research;Rhesus;Safety;seropositive;Shapes;simian human immunodeficiency virus;success;transgene expression;Universities;Validation;vector;Veterinarians;Viral;Viral load measurement;Viral Load result;Viral reservoir;virology;Wisconsin;Work

PROJECT_TITLE: Core B: Non-human primate core


PI_NAMEs: GAO, GUANGPING  (contact)

PROJECT_TERMS: adeno-associated viral vector;Animals;Antibodies;Autoantigens;Baltimore;Bypass;Capsid;Cell Culture System;Cell Culture Techniques;Cell Line;Cells;Chromatography;Circulation;clinical development;Data;design;DNA cassette;Enrollment;Evaluation;experience;Future;Gene Expression;Gene Transfer;Goals;HIV;HIV Infections;HIV vaccine;Human;Immunity;Immunization;in vivo;Infection;inhibitor;Intramuscular Injections;Macaca;Macaca mulatta;Mediating;Medicine;Methods;Modeling;Mus;Muscle;Nature;Neck;nonhuman primate;novel;Production;programs;Protein Secretion;Publishing;Quality Control;Recombinant adeno-associated virus (rAAV);Reproducibility;Research Personnel;Rhesus;Roller Bottle;Serotyping;SIV;Suspensions;System;technology platform;Testing;Therapeutic;Transfection;transgene expression;Transgenes;Tropism;Vaccine Design;vaccine trial;vector;vector genome;Viral Vector;Work

PROJECT_TITLE: Core C: Viral vector core


NIH_SPENDING_CATS: Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: RICHMOND

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Human granulocytic anaplasmosis (HGA) is an emerging, potentially fatal tick-transmitted disease caused by a bacterium that invades white blood cells called neutrophils. The proposed research will functionally dissect surface proteins of the HGA agent and assess if immunizing against them protects against infection. These studies will benefit design of strategies for preventing HGA.

PI_NAMEs: CARLYON, JASON A (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: alanine aminopeptidase;Anaplasma phagocytophilum;Anaplasmosis;Antibodies;Antigens;Bacteria;Bacterial Adhesins;Binding;Binding Proteins;Blocking Antibodies;Cells;cohort;Complex;Country;Cytoskeletal Modeling;Cytoskeleton;Data;defined contribution;design;Disease;disease transmission;Etiology;Event;Exhibits;feeding;Funding;granulocyte;host-microbe interactions;Human;Immunize;improved;In Vitro;in vivo;Incidence;Infection;Infection prevention;Integrins;Invaded;ITGB2 gene;Knowledge;Leukocytes;Licensing;Link;Lyme Disease;Mammals;Mediating;Membrane Microdomains;Membrane Proteins;molecular modeling;Mus;neutrophil;Organism;Oxidoreductase;P-selectin ligand protein;Pathogenesis;pathogenic bacteria;Phosphorylation;prevent;Process;Protein Disulfide Isomerase;Public Health;receptor;receptor binding;Receptor Cell;Research;Research Support;Rickettsia;Role;Route;Signal Pathway;Signal Transduction;Strategic Planning;Sulfhydryl Compounds;Surface;synergism;Syringes;T cell response;tick feeding;tick transmission;tick-borne;Tick-Borne Diseases;Tick-Borne Infections;transmission process;Tropism;United States;United States National Institutes of Health;uptake;vaccine development;Vaccines;vector;yeast two hybrid system;Yeasts

PROJECT_TITLE: The roles of Anaplasma phagocytophilum surface proteins in infection

STUDY_SECTION: HIBP

STUDY_SECTION_NAME: Host Interactions with Bacterial Pathogens Study Section[HIBP]


PI_NAMEs: MARTINS, MAURICIO DE AGUIAR (contact)

PROJECT_TERMS: Address;Animals;Antibodies;Antibody Response;antibody-dependent cell cytotoxicity;antiretroviral therapy;Capsid;CD4 Antigens;Cells;Collaborations;cost;Data;Dependovirus;design;Disease remission;Dose;Epitopes;Evaluation;Excision;Fc domain;fitness;Glycoproteins;Goals;HIV Envelope Protein gp120;HIV-1;HIV-2;Human;immune clearance;immunogenic;immunogenicity;improved;In Vitro;Infection;Macaca;Macaca mulatta;Measures;Mediating;mimetics;Monkeys;Mus;neutralizing antibody;Patients;Pattern;peptidomimetics;Productivity;promoter;Property;Prophylactic treatment;Proviruses;receptor;Reporting;Resistance;Resources;Safety;Serum;simian human immunodeficiency virus;SIV;Testing;Therapeutic;tyrosine O-sulfate;Vaccination;Variant;vector;vector genome;Viral;Viral reservoir;Virus;Virus Replication

PROJECT_TITLE: Project 1: Establishing a robust functional cure


PI_NAMEs: DESROSIERS, RONALD C (contact)

PROJECT_TERMS: Acceleration;Address;adeno-associated viral vector;adenovirus mediated delivery;Animals;Anti-viral Agents;Antibodies;Antibody Response;Antibody Therapy;Antigen Targeting;Antigens;arm;Binding;Bispecific Antibodies;Blood specimen;Capsid;Cells;Collection;CpG dinucleotide;Data;design;Development;Dose;efficacy evaluation;Ensure;Erythrocytes;expectation;experimental study;Funding;Goals;HIV;HIV-1;Human;human monoclonal antibodies;Immune Tolerance;Immunity;Immunization;immunogenic;Immunoglobulin Constant Region;Individual;Infection;Ingestion;Injections;Intramuscular Injections;Light;Literature;Macaca;Macaca mulatta;Mediating;Monitor;Monkeys;Monoclonal Antibodies;Mus;Mutation;Oral;oral tolerance;oral tolerization;Paper;Persons;Pharmaceutical Preparations;Pharmacotherapy;Program Research Project Grants;promoter;Prophylactic treatment;Protocols documentation;Publications;Publishing;Regimen;Resistance;Rhesus;Safety;simian human immunodeficiency virus;Technology;Testing;Therapy trial;Transgenes;United States National Institutes of Health;vector;Viral Load result;Virus Replication

PROJECT_TITLE: Project 2: Limiting anti-drug antibodies


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Biotechnology;Brain Disorders;Clinical Research;Immunization;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_DEPT: NEUROLOGY

PHR: Multiple sclerosis is a common and disabling autoimmune disease of the central nervous system in which B cells play a central pathogenic role. The principal goal of the project is to identify the disease trigger(s), and to understand the mechanisms underlying disease progression. Central elements of this initiative include large well-characterized clinical populations, comprehensive biobanked materials, serial magnetic resonance imaging of the brain and spinal cord using novel quantitative techniques, complete genetic information, and state of the art tools to investigate B cell biology including single cell B cell transcriptomics, recombinant antibody libraries, and phage-displayed synthetic protein arrays to identify antibody reactivities against foreign and self proteins.

PI_NAMEs: HAUSER, STEPHEN L (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: Acute;Affect;Antibodies;antibody libraries;Axon;B-Lymphocytes;biobank;Brain imaging;Cells;Cellular biology;Cerebrospinal Fluid;Chronic;chronic autoimmune disease;Clinical;CNS autoimmune disease;cohort;Data;Disabling;Disease;Disease Progression;Elements;Fingerprint;Genetic Determinism;genetic information;Goals;Human;improved;Individual;Inflammation;information organization;Magnetic Resonance Imaging;Mediating;microbial;Molecular;Multiple Sclerosis;Myelin;Neurologic Dysfunctions;Neurons;novel;Oligodendroglia;Onset of illness;Pathogenicity;Pathology;Patient-Focused Outcomes;Patients;peripheral blood;Phage Display;Pharmaceutical Preparations;Play;Population;Progressive Disease;Protein Array;Proteins;receptor;Recombinant Antibody;Research;Role;screening;Serial Magnetic Resonance Imaging;Serum;Spinal Cord;synthetic protein;Techniques;Technology;Therapeutic;tool;transcriptomics;United States;Viral

PROJECT_TITLE: The Role of B cells in the Origin and Progression of Multiple Sclerosis


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Project Narrative Activating KRAS mutations are required for the maintenance of pancreatic cancer, the major cancer with the lowest 5-year survival rate, substantiating the need for effective anti-KRAS targeted therapies. The first FDA- approved KRASG12C inhibitor, sotorasib, is limited in PDAC because less than 2% of KRAS mutations in pancreatic cancer patients have KRASG12C mutations, and because patients who initially respond to treatment eventually relapse due to the onset of drug resistance mechanisms. My research studies address these issues by identifying resistance mechanisms to other KRAS mutations and define combination approaches to enhance the long-term patient response to KRAS inhibitors.

PI_NAMEs: WATERS, ANDREW M (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Achievement;Address;Automobile Driving;Binding;Biological;Biology;Cancer Etiology;Cancer Model;cancer subtypes;Cell Culture Techniques;Cessation of life;Clinical;clinical candidate;Clinical effectiveness;Codon Nucleotides;Combined Modality Therapy;CRISPR/Cas technology;Data;design;Development;Drug Combinations;Drug resistance;effective therapy;Event;Exhibits;FDA approved;Frequencies;Genetic;Goals;Growth;Impairment;inhibitor;KRAS2 gene;KRASG12D;Libraries;Lipids;loss of function;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolism;Modeling;Molecular;mouse model;mutant;Mutation;National Cancer Institute;Non-Small-Cell Lung Carcinoma;novel;Observational Study;Oncogenic;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;patient response;Patients;pharmacologic;Phosphotransferases;preclinical development;Property;Proteins;rare variant;Relapse;relapse patients;Research;research study;Resistance;resistance mechanism;response;Role;Signal Pathway;Signal Transduction;Survival Rate;System;targeted treatment;Therapeutic;therapy resistant;Tissues;tumor;tumor microenvironment;tumorigenic;Validation

PROJECT_TITLE: Identification of resistance mechanisms to direct KRAS inhibition in pancreatic cancer