ED_INST_TYPE: COMPUTER CENTER

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: IRVINE

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative This project aims to establish a Summer Institute in Biostatistics and Data Science at the University of Cal- ifornia, Irvine. The institute will attract new students to the ﬁelds of Biostatistics and Biomedical Data Science. Students will be trained in methodology and computing and will apply this training to a data analysis project under guidance of biostatistics and biomedical science co-mentors. The investigators will make a concerted effort to recruit students from groups underrepresented in the biomedical and mathe- matical sciences. Students will receive career guidance, including advice about graduate school application process. 1

PI_NAMEs: DOGUCU, MINE ;GILLEN, DANIEL L;MININ, VOLODYMYR  (contact);SHAHBABA, BABAK

PROGRAM_OFFICER_NAME: GEZMU, MISRAK

PROJECT_TERMS: Asian Americans;Attention;Bachelor's Degree;Big Data;Biological Sciences;biomedical data science;Biomedical Research;biomedical scientist;Biometry;California;Cardiovascular Diseases;career;career preparation;clinical trial analysis;college;Communication;computer science;Data;Data Analyses;data hub;data management;Data Science;data science education;data visualization;data wrangling;Degree program;design;Disease;diversity and inclusion;Educational process of instructing;Electronic Health Record;Ensure;experience;Experimental Designs;Exposure to;Faculty;Future;Genomics;Goals;graduate school;Hispanic-serving Institution;Home;Image;Image Analysis;improved;Infectious Disease Epidemiology;infectious disease model;Informatics;Information Sciences;Infrastructure;innovation;Institution;instructor;interest;Investments;job market;Leadership;lectures;Life;Linear Models;Machine Learning;mathematical sciences;Mathematics;Mentors;Methodology;Methods;Mission;Modernization;Multivariate Analysis;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Native Americans;Oral;Pacific Island Americans;Patient Recruitments;posters;Preparation;Prevalence;Probability;Process;programs;Qualifying;recruit;Reporting;Research;Research Personnel;Rest;Sampling;Schools;Science;skills;statistics;STEM field;Student recruitment;student training;Students;summer institute;Surveys;symposium;technical writing;Training;transcriptomics;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;unstructured data;Visual;Vocational Guidance;Writing

PROJECT_TITLE: Irvine Summer Institute in Biostatistics and Data Science


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_FIPS: US

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because results from this study are expected to lead to improved regenerative medicine-based therapies for muscle damage after injury to the shoulder tendons. These studies will also result in greater understanding of the role of cell transplantation in muscle repair. This is relevant to the NIH's mission as this research provides new methodologies that will lead directly to better treatments for rotator cuff injuries.

PI_NAMEs: TEMENOFF, JOHNNA S (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Address;Affect;Aftercare;angiogenesis;appropriate dose;Atrophic;beta-Galactosidase;Biochemical;Biocompatible Materials;Biological Assay;Cell Aging;Cell Surface Receptors;Cell Therapy;Cell Transplantation;Cells;Cellular Metabolic Process;Clinical;design;Disease;Early identification;Elderly;Engineering;Enzyme-Linked Immunosorbent Assay;experimental study;fitness;Flow Cytometry;Gene Expression;General Population;Glycosaminoglycans;Goals;healing;Heterogeneity;Histology;Human;Hydrogels;immunoregulation;improved;In Situ;In Vitro;in vitro Assay;in vivo;Injections;Injury;innovation;Integrins;Isometric Exercise;Laboratories;Lead;Ligands;Macrophage;Measures;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Metabolic;Metabolism;metabolomics;Methodology;Methods;migration;Mission;Modeling;Modulus;monocyte;Muscle;muscle degeneration;Muscle function;muscle regeneration;muscle repair;Musculoskeletal Diseases;Myoblasts;N-Cadherin;Natural regeneration;Operative Surgical Procedures;Outcome;Outcome Measure;particle;Pathway Analysis;Patient-Focused Outcomes;Phase;Population;Production;Property;Public Health;Rattus;recruit;regenerative;Regenerative Medicine;repaired;Research;response;Role;Rotator Cuff;rotator cuff injury;rotator cuff tear;screening;senescence;shoulder injury;Site;Stains;stem cell expansion;stem cell therapy;Stromal Cells;Styrenes;supraspinatus muscle;surgery outcome;Techniques;Tendon structure;Testing;Therapeutic;tissue culture;tissue regeneration;Tissues;tool;Transplantation;United States National Institutes of Health;Work

PROJECT_TITLE: Biomaterials to enhance the efficacy of MSCs for rotator cuff repair

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Hematology;Human Genome;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Hematopoiesis is the process by which blood cells form and replenishes the various cell types present in blood through differentiation of blood-forming stem and progenitors. Hematopoiesis requires a series of progressive cell fate decisions, which can go awry in diseases such as anemias. Here, the studies proposed are focused on how individual cells make these fate decisions to form specific cell types including red blood cells and platelets.

PI_NAMEs: THOMPSON, EVRETT  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adult;Anemia;ATAC-seq;Benign;Biological Models;Blood;Blood Cells;Blood Platelets;Bone Marrow;Candidate Disease Gene;candidate identification;career;CD34 gene;Cell Culture Techniques;Cell Differentiation process;cell fate specification;Cell Lineage;Cell Therapy;cell type;Cells;Chimeric Proteins;Chromatin;Cleavage Under Targets and Release Using Nuclease;Computer Analysis;Data;Data Set;demethylation;Disease;endonuclease;Enhancers;Epigenetic Process;Erythrocytes;Erythroid;Erythroid Progenitor Cells;Erythropoiesis;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Genome;Genomics;Goals;granulocyte;Guide RNA;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;histone modification;Human;Individual;inhibitor;insight;Investigation;KDM1A gene;Lead;Lysine;Maintenance;Malignant - descriptor;Mediating;Megakaryocytes;Megakaryocytopoieses;Messenger RNA;Modification;monocyte;Mus;Myelogenous;Pathology;Pathway interactions;peripheral blood;Play;Population;Process;Production;progenitor;programs;promoter;Publishing;Research;Research Personnel;Role;Series;Site;Specific qualifier value;stem;stem cell fate;stem cell fate specification;stem cell population;stem cells;Testing;Training;transcriptome sequencing

PROJECT_TITLE: Establishing the role and mechanisms of LSD1 during megakaryocytic and erythroid fate commitment


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Relevance: Heart failure (HF), a progressive disease with a poor prognosis, is characterized by inflammation and the expansion of tissue-injurious macrophages in the heart; however, the specific macrophage populations and pathways responsible for cardiac injury, dysfunction, and fibrosis remain unclear. We will test a novel hypothesis for the pathogenesis of inflammation in HF - that it is driven in large part by macrophages in the failing heart expressing the protein CD206 and a subunit of the receptor for interleukin-4 (IL-4Ra). We further propose that therapeutically targeting these CD206+IL-4Ra+ macrophages represents a novel and effective approach to alleviating cardiac inflammation and reversing adverse cardiac remodeling in HF.

PI_NAMEs: PRABHU, SUMANTH D (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Adoptive Cell Transfers;Adoptive Transfer;Antibodies;Antisense Oligonucleotides;Attenuated;Behavior;beta-Chemokines;Biological Assay;Biological Response Modifiers;Bone Marrow;C57BL/6 Mouse;Cardiac;Cell Proliferation;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;chemokine;chemokine receptor;Chronic;Classification;Clinical;Congestive Heart Failure;Coronary;cytokine;Data;Development;Disease;disease model;Disease Progression;Exhibits;Female;Fibrosis;Flow Cytometry;Functional disorder;Genes;Genetic;Genetic Markers;Genetic Transcription;Heart;heart cell;Heart failure;Heart Injuries;Human;Immune;immune activation;Immunohistochemistry;immunomodulatory strategy;immunoregulation;in vivo;Inflammation;Inflammatory;Injections;innovation;insight;Interleukin 4 Receptor;Interleukin-10;Interleukin-13;Interleukin-4;Ischemia;ischemic cardiomyopathy;kinase inhibitor;Knockout Mice;Late Effects;Left Ventricular Remodeling;Ligation;Link;Macrophage;male;Measures;Mediator;Modeling;monocyte;Mus;Myelogenous;Myocardial Infarction;Myocardial Ischemia;Myocarditis;Myocardium;Myofibroblast;neutralizing antibody;novel;novel strategies;Pathogenesis;Pathologic;Pathway interactions;Phagocytes;Phagocytosis;Population;Prognosis;Progressive Disease;Proliferating;Proteins;PTPRC gene;recruit;repaired;Role;self renewing cell;self-renewal;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small molecule;Sorting;source localization;Spatial Distribution;Tamoxifen;targeted treatment;Testing;Therapeutic;therapeutic target;Tissue Expansion;tissue injury;Tissues;transcriptomics;virtual

PROJECT_TITLE: Cardiac Macrophages as Disease Drivers in Chronic Ischemic Heart Failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CCHF-S(01)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: PROJECT NARRATIVE >200k people in the U.S. undergo cardiac catheterization for their stable coronary artery disease (CAD) each year to stratify risk of major adverse cardiac events in a patient population having a wide range of outcomes, with annual mortality rates varying by a factor of 6 between “low risk” and “high risk” stable CAD patients. Current imaging and non-imaging techniques for risk stratification and prediction of adverse events (such as myocardial infarction) based on independent indicators such as lesion structure and plaque composition are largely unsuccessful. By leveraging recent advances in ultrasound transducer array design, data reconstruction, high frame rate image formation, and catheter design, this project will develop an ultrasound imaging catheter designed to characterize the comprehensive coronary enviornment based on the full mechanics and hemodynamics surronding the stenosis.

PI_NAMEs: LINDSEY, BROOKS D (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Adverse event;Angiography;Animal Model;biomechanical test;Biomechanics;Blood;Blood flow;Blood Flow Velocity;Cardiac;Cardiac Catheterization Procedures;cardiac magnetic resonance imaging;Cardiology;Catheterization;Catheters;Clinical;Clinical Trials;Computer Models;Cone;Coronary;Coronary Arteriosclerosis;coronary lesion;cost;Data;Death Rate;design;Development;Ensure;Environment;Evaluation;Event;experience;Family suidae;Geometry;Health Care Costs;hemodynamics;high risk;Histology;Image;image guided intervention;imaging approach;Imaging technology;improved outcome;in vivo;Intervention;Length;Lesion;Lesion by Morphology;Liquid substance;Maps;Measurement;Measures;mechanical drive;Mechanics;meetings;Modeling;Morphology;Motion;multidisciplinary;Myocardial Infarction;novel;Outcome;patient population;Patients;Performance;Peripheral;Persons;Physiological;pre-clinical;Process;prognostic;Publishing;radiologist;reconstruction;Research Personnel;Resolution;Risk;risk prediction;risk stratification;Rupture;Safety;Scanning;Severities;shear stress;software development;Stable Disease;Stenosis;Structure;System;Techniques;Technology;technology development;temporal measurement;Thinness;Time;Tissues;Transducers;treatment strategy;Ultrasonic Transducer;Ultrasonography;ultrasound;Uncertainty;Validation;virtual;X-Ray Computed Tomography

PROJECT_TITLE: 3D Multi-Functional Catheter-Based Imaging of Coronary Lesion Composition, Structure, and Hemodynamics in Intermediate Stenoses

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Diabetes;Nutrition;Obesity;Prevention;Uterine Cancer;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Obesity increases the risk of death from endometrial cancer and predisposes to high levels of insulin; however, it is unclear if these findings are directly linked. The growth of endometrial cancer cells is stimulated by insulin via the phosphatidylinositol 3-kinase (PI3K) pathway. This proposal will target the PI3K pathway in human endometrial cancer using a combination of dietary and pharmacologic strategies that reduce insulin together with small molecule inhibitors of PI3K to prevent the growth of endometrial cancer.

PI_NAMEs: GONCALVES, MARCUS DASILVA (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Acute;Address;Adult;Adverse effects;Animal Model;Apoptosis;Apoptotic;Biochemical;Biochemical Markers;Blood;cancer cell;cancer therapy;cancer type;Carbohydrates;Carcinoma;cell growth;Cessation of life;Clinical;clinical care;Clinical Data;clinical practice;Clinical Research;Clinical Trials;combat;Combined Modality Therapy;Consumption;Data;Death Rate;detection of nutrient;Development;Diazoxide;Diet;dietary;Dietary Intervention;drug efficacy;effectiveness validation;Endocrine system;Endocrinologist;Endometrial Carcinoma;Epithelium;feasibility trial;feeding;Genetic;Glucose;glycemic control;Goals;Growth;Histologic;hormone therapy;Human;Human Genetics;Hyperglycemia;Hyperinsulinism;Implant;Incidence;inhibitor;Insulin;insulin signaling;Intervention;Intervention Trial;kinase inhibitor;Knowledge;Link;Malignant Female Reproductive System Neoplasm;Medical Oncologist;Memorial Sloan-Kettering Cancer Center;Metabolism;mortality risk;mouse model;Mus;Nature;novel;novel strategies;novel therapeutic intervention;Obesity;Obesity Epidemic;open label;Organoids;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phase;phase 2 study;Phosphotransferases;PIK3CG gene;Potassium Channel;pre-clinical;Pre-Clinical Model;prevent;Proliferating;Publishing;Qualifying;Randomized;Recurrence;Research;response;Risk;Role;safety testing;Signal Pathway;Signal Transduction;small molecule inhibitor;Sodium;symporter;targeted treatment;Testing;Tissues;Translating;translational approach;translational scientist;treatment response;tumor;tumor growth;tumor initiation;Tumor Markers;tumor progression;Tumor Tissue;Urine;Uterus;Woman;Women's study;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Combination Therapies Targeting Insulin Signaling in Endometrial Cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE By 2030, approximately 20% of the US population is expected to be 65 years and older, and so there is an urgent need for better understanding of the physiological changes and mechanisms that underlie normal and pathological aging. This research training grant will provide annual support for 5 pre-doctoral students and 3 postdoctoral fellows, and will represent an educational cornerstone of the OHSU Healthy Aging Alliance – an organization that involves basic and clinical researchers, health care providers, and also elderly representatives from the local community. The proposed Neuroscience of Aging, Neurodegeneration and Alzheimer's Disease program will thus provide trainees with a “bench-to-bedside” framework in which to conduct their research, and will better prepare them for future research careers that focus on the development of safe and effective therapies for aging-related neurological disorders.

PI_NAMEs: RABER, JACOB  (contact);URBANSKI, HENRYK F

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Optogenetics is a powerful technique for modulating precisely selected neural circuits, but despite having numerous research and therapeutic applications, achieving neuromodulation that significantly impacts behavior in primates has proved challenging. Here we develop new optogenetic expression and stimulation techniques to achieve this goal in freely behaving primates. This will allow us to better study and develop translational therapies targeting the neural circuitry underlying a variety of neurological and psychiatric disorders in human populations.

PI_NAMEs: PLATT, MICHAEL L (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Affect;Animal Model;Animals;Antigen-Antibody Complex;Behavior;Behavioral;Biological Assay;biomaterial compatibility;Brain;brain control;Brain Diseases;brain volume;Cardiac pacemaker;cell type;Chronic;cisterna magna;Clinical;clinically significant;Collaborations;commercialization;Contrast Media;Convection;delivery vehicle;design;Devices;Diffusion;Dissection;Dura Mater;Encephalitis;energy efficiency;Epilepsy;experience;experimental study;FDA approved;flexibility;fly;Gene Delivery;Gene Expression;gene therapy;General Population;Generations;Genes;Genetic;Goals;Histology;Human;Immune response;Immune system;immunoreaction;Implant;in vivo;Individual;individuals with autism spectrum disorder;industry partner;Injections;Lasers;Light;light weight;Lighting;loss of function;Macaca;Magnetic Resonance Imaging;Mediating;Medical;Mental disorders;microsystems;millisecond;Monkeys;Movement;multidisciplinary;Mus;Nervous System Disorder;neural;neural circuit;neural implant;Neuroanatomy;Neurologic;Neurons;neurophysiology;neuroregulation;Neurosciences;neurotechnology;new technology;nonhuman primate;open data;Operative Surgical Procedures;Opsin;optogenetics;Paresis;Partial Epilepsies;Patients;Pattern;Persons;Physical Restraint;Pilot Projects;Polymers;Population;Primates;programs;promoter;Proteins;Research;Research Personnel;Resolution;restraint;Rodent;Safety;Scotoma;Serotyping;Shapes;Source;Specificity;Surface;targeted treatment;Techniques;Technology;technology platform;Testing;Therapeutic;Thick;Time;Tissues;tool;translational potential;translational therapeutics;Viral;virology;wearable device;wireless;wireless electronic

PROJECT_TITLE: Optimizing Optogenetics for Cell-type-specific Control in Freely-moving Primates

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention;Sleep Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Alzheimer’s disease and related dementias (ADRD), including mild cognitive impairment (MCI), are becoming among the most prevalent causes of disability, death and healthcare costs worldwide. Sleep and circadian rhythm disturbances are common among individuals with MCI as well as their spouses/ partners and may increase risk of the development of ADRD in both patients and partners. This is the first study to systematically investigate sleep as a shared health behavior within couples in which one member has MCI, and the degree to which sleep and circadian disturbances impact both partners health and well-being, including cognitive decline and risk for ADRD.

PI_NAMEs: BARON, KELLY GLAZER (contact);TROXEL, WENDY M

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: actigraphy;Address;Adult;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavior;biobehavior;Biological;caregiving;Cellular Phone;Cessation of life;circadian;Circadian Dysregulation;Circadian Rhythms;Cognition;Cognitive;cognitive function;cognitive testing;Couples;daily functioning;dementia risk;Development;disability;executive function;experience;follow-up;Functional impairment;Health;Health behavior;Health Care Costs;Health Expenditures;healthy aging;Impaired cognition;Impairment;improvement on sleep;Individual;innovation;Intervention;Life;Measures;member;Memory;men;mild cognitive impairment;Moods;mortality;Neuropsychology;novel;older adult;Outcome;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Physiology;poor sleep;Population;Premature Mortality;Process;processing speed;prospective;Prospective Studies;Protocols documentation;Quality of life;Research;response;Rest;Risk;Risk Reduction;Role;Sampling;sex;Sleep;Sleep disturbances;sleep pattern;social;social culture;Spouses;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Dyadic Sleep, Biobehavioral Rhythms and Cognitive Function in Older Adults: Implications for Alzheimer’s Disease

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The precise establishment of neuronal connectivity during development is critical for normal nervous system function. This proposal examines the molecular mechanisms underlying local protein synthesis to determine how it regulates the formation of neuronal connectivity. These studies will provide a greater understanding about the complex nature of brain development in health and disease.

PI_NAMEs: WELSHHANS, KRISTY  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Actins;Acute;Adhesions;Axon;axon growth;axon guidance;beta Actin;Binding;Biological Assay;Brain;Complex;Coupled;Cues;Cytoskeletal Modeling;Cytoskeleton;Data;Development;Disease;experimental study;extracellular;Extracellular Matrix;Extracellular Matrix Proteins;Filopodia;Growth;Growth Cones;Health;Integrins;Knowledge;Laminin;Link;Location;Mediating;Messenger RNA;Methods;Microfilaments;Microtubules;Molecular;Motility;Movement;mRNA Translation;Mus;Nature;Nervous System;nervous system development;Nervous System Disorder;Nervous System Physiology;neurodevelopment;Neurons;neurotransmission;novel;Positioning Attribute;Process;Protein Biosynthesis;Protein Isoforms;Proteins;Regulation;Reporter;Research;response;RiboTag;Role;Signal Induction;Signal Pathway;Signal Transduction;Site;Structure;Synapses;synaptogenesis;Testing;Total Internal Reflection Fluorescent;trafficking;Translating;translating ribosome affinity purification and RNA-sequencing;Translational Regulation;Translations

PROJECT_TITLE: Regulating axon guidance through local translation at adhesions

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MADISON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Multidrug-resistant pathogens pose a serious public health problem that requires creative solutions. I propose combining and reimaging old strategies to combat Gram-positive pathogens through manipulation of the bacteria’s own signaling system. This work will provide valuable insight into how bacteria produce the signals that trigger virulence while also developing new tools to fight pathogens.

PI_NAMEs: WIDNER, DANIELLE LEE (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Affect;Amino Acids;Anabolism;Attenuated;Bacteria;Behavior;Biology;Caenorhabditis elegans;chemical synthesis;Chemicals;clinically significant;Clostridium difficile;combat;Creativeness;design;Endopeptidases;Engineering;Environment;extracellular;fighting;Genetic Transcription;Goals;host colonization;human pathogen;Image;Infection;inhibitor;insight;interest;Investigation;Knowledge;Laboratories;Libraries;Listeria monocytogenes;Location;Methods;Modeling;Molecular;multi-drug resistant pathogen;mutant;Mutate;Mutation;N-terminal;nanomolar;non-Native;novel;novel strategies;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;peptide analog;Peptide Biosynthesis;Peptide Hydrolases;peptide I;Peptide Signal Sequences;Peptide Synthesis;Peptides;Population Density;prevent;Probiotics;Process;Production;protein aminoacid sequence;Proteins;Proteolysis;Public Health;quorum sensing;Recording of previous events;Regulator Genes;Reporter;screening;Signal Transduction;Site;Specificity;Staphylococcus aureus;Staphylococcus epidermidis;System;Tail;Testing;therapeutic target;tool;Variant;Virulence;Work

PROJECT_TITLE: Biosynthesis of Non-Native Autoinducing Peptides


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Our proposal aims to investigate the molecular mechanisms of transcriptional control of neuronal plasticity and memory storage. This basic research will provide new and significant insights into the function of normal brain, and will facilitate the development of new effective treatments of neurological disorders.

PI_NAMEs: MAXIMOV, ANTON  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Acute;Address;Affect;Amygdaloid structure;Animals;Architecture;Area;Ataxia Telangiectasia;awake;Basic Science;Binding Proteins;Biological;blood-brain barrier crossing;Brain;Brain imaging;Brain Mapping;Brain region;Caenorhabditis elegans;calcium indicator;Cell Nucleus;cell type;Cells;chemical genetics;Chromatin;Code;conditional knockout;connectome;Cytoplasm;deep sequencing;Development;Drosophila genus;effective therapy;Electron Microscopy;Electrophysiology (science);entorhinal cortex;Environment;ERG gene;experience;Face;fear memory;gain of function;gene induction;Genes;Genetic;genetic approach;genetic manipulation;Genetic Techniques;Genetic Transcription;Glutamates;Goals;HDAC4 gene;HDAC5 gene;Hippocampus;Histone Deacetylase;Homologous Gene;Human;human disease;Image;in vivo;in vivo imaging;Individual;insight;Interneurons;Learning;Link;Maps;Mass Spectrum Analysis;Mediating;Memory;memory acquisition;memory consolidation;memory encoding;Mental Retardation;Microscopy;Modeling;Molecular;Mus;Mutant Strains Mice;Nervous System;Nervous System Disorder;neural;neural circuit;Neuronal Plasticity;Neurons;novel;Nuclear;Nuclear Import;Organelles;Parkinson Disease;patch clamp;Pathway interactions;Pattern;Pharmaceutical Preparations;pharmacologic;Physiological;Play;programs;Protein Isoforms;Proteins;recruit;Reporter;Repression;Research;response;Role;Scanning Electron Microscopy;Sensory;sensory input;sensory stimulus;Signal Transduction;Slice;small molecule;spatiotemporal;Structure;Synapses;Synaptic plasticity;Syndrome;Testing;Time;tool;transcription factor;Transcription Repressor;Transcriptional Regulation;two-photon;Uncertainty

PROJECT_TITLE: Transcriptional Control of Synaptic Plasticity by Class IIa HDACs


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE (Public health relevance statement) Inexpensive, reversible, and long-acting contraceptives for men are needed to help address world population growth and medical issues associated with unplanned pregnancy. The blood-testis barrier (BTB) and blood- epididymal barrier (BEB) pose major obstacles in developing male contraceptives, as these drugs must pass through these barriers to reach their targets. This work will facilitate the identification and development of new male contraceptives by determining how chemical features of a small molecule influence its transfer from the blood and accumulation behind these barriers.

PI_NAMEs: LI, FENG  (contact)

PROGRAM_OFFICER_NAME: ALLEN, CATHERINE LEIGH

PROJECT_TERMS: Address;Affect;analog;anti-depressive agents;Anti-Retroviral Agents;Area;Binding Proteins;Biological Assay;Blood;Blood-Testis Barrier;Bromodomain;Chemical Structure;Chemicals;Complement;Contraceptive Agents;Contraceptive methods;contraceptive target;Data;Descriptor;Development;Diffusion;drug discovery;drug market;Drug or chemical Tissue Distribution;drug testing;drug-like compound;Epididymis;Human;Hydrogen Bonding;Immune;improved;Infection;Informatics;inhibitor;insight;Knock-out;Knockout Mice;lipid solubility;liquid chromatography mass spectrometry;Liquid substance;Male Contraceptive Agents;Male Genital Organs;Malignant Neoplasms;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measures;Mediating;Medical;Membrane;men;Methods;Modeling;Modification;Molecular;Molecular Structure;mouse model;Mus;National Institute of Child Health and Human Development;Natural Products;novel;Permeability;Pharmaceutical Preparations;Phase;physical property;Piperazines;Plasma;Plasma Proteins;Population Growth;Positioning Attribute;prevent;Property;Protocols documentation;public health relevance;Publishing;rational design;reproductive tract;scaffold;Series;small molecule;Spatial Distribution;sperm cell;spermatogenic epithelium structure;Structure;Testing;Testis;Therapeutic;trend;unintended pregnancy;uptake;Variant;Wild Type Mouse;Work;Xenobiotics

PROJECT_TITLE: Elucidating Chemical Features that Block or Facilitate Passage across the Blood-Testis and/or Blood-Epidydimal Barriers in Mice


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Glioma is the most prevalent form of adult brain cancer and has an extremely poor prognosis. The work proposed will define transcriptional networks and chromatin conformation mechanisms that regulate glioma tumorigenesis and address some of the fundamental issues that have hampered the progress toward identifying new treatments of this deadly disease.

PI_NAMEs: GLASGOW, STACEY MARIE (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Address;Adult;Architecture;Astrocytes;Biochemical;Biological Assay;Biology;Cell Differentiation process;Cell Fate Control;Central Nervous System;Chick;Chromatin;Chromatin Loop;chromosome conformation capture;Complex;Coupled;Data;Development;Diagnosis;Disease;DNA;DNA Binding;DNA Sequence Alteration;driver mutation;effective therapy;Electroporation;Embryo;embryonic stem cell;Enhancers;gain of function;Gene Expression;Gene Expression Regulation;gene function;Gene Targeting;Generations;Genes;Genetic Transcription;genome-wide analysis;Genomic Instability;glial cell development;gliogenesis;Glioma;glioma cell line;Gliomagenesis;Hi-C;Human;in utero;In Vitro;in vitro Assay;in vivo;insight;Lead;Link;loss of function;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Mediating;Mediator;Modeling;Molecular Conformation;Molecular Target;mouse genetics;mouse model;mRNA Expression;Mus;nerve stem cell;Neuroglia;Neurons;NF1 gene;NFIA gene;novel;Nuclear;Oncogenes;Pathologic;Pathway interactions;Patients;Peptide Initiation Factors;Primary Brain Neoplasms;Prognosis;programs;Progression-Free Survivals;promoter;protein expression;Proteins;PTEN gene;Regulatory Element;Role;stem cell population;Structure;Survival Rate;System;Techniques;Technology;Therapeutic;Tissue Microarray;TP53 gene;transcription factor;tumor;Tumor Cell Biology;tumorigenesis;Work

PROJECT_TITLE: Defining transcriptional networks and chromatin conformations regulating glioma tumorigenesis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Stanford/UNC Biomimetic U19 Research Center PROJECT NARRATIVE – CENTER OVERVIEW Viral and bacterial infections of the lung and gastrointestinal tract are a leading cause of illness worldwide. Here, we grow human lung, intestine and stomach as 3-dimensional “organoids” in an incubator and add disease- causing bacteria and viruses to create new holistic models of COVID-19 and gastrointestinal diseases that could improve the understanding and treatment of these afflictions.

PI_NAMEs: AMIEVA, MANUEL R;KUO, CALVIN J (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 2019-nCoV;3-Dimensional;absorption;Acute;Acute Respiratory Distress Syndrome;adaptive immune response;Air;airway epithelium;Alveolar;Alveolus;Apical;Bacteria;Bacterial Infections;Basic Science;Binding;Biology;Biomimetics;Cell Communication;cell type;Cells;Chiroptera;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communicable Diseases;comparative;Coronavirus;COVID-19;COVID-19 pandemic;COVID-19 test;CRISPR interference;CRISPR screen;CRISPR-mediated transcriptional activation;cytokine release syndrome;Digestion;Disease;Distal;emerging pathogen;Enteral;enteric infection;Epidemic;Epithelium;Epitopes;Escherichia coli;Etiology;Exhibits;Experimental Models;Functional disorder;gastric organoids;gastrointestinal;Gastrointestinal Diseases;gastrointestinal epithelium;Gastrointestinal tract structure;Genes;genetic manipulation;Genetic Screening;global health;Glycoproteins;Goals;Growth;health economics;Helicobacter pylori;Human;human coronavirus;human disease;human model;Immune;immune cell infiltrate;Immune response;Immunity;improved;In Vitro;Incubators;Infection;Influenza;Innate Immune Response;Intestines;Invaded;Investigation;Lead;Liquid substance;Lung;Lung infections;M cell;Mediating;Methods;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Mission;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;multidisciplinary;multiplexed imaging;mutant;Myelogenous;National Institute of Allergy and Infectious Disease;neutralizing monoclonal antibodies;new epidemic;Norovirus;North Carolina;novel;novel coronavirus;Organoids;Outcome;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;permissiveness;Play;Pneumonia;Population;Predisposition;preservation;Prevention;reconstitution;Recurrence;Research;Research Personnel;Research Project Grants;Resistance;respiratory;Respiratory Failure;Respiratory Mucosa;respiratory pathogen;Respiratory Therapy;Respiratory Tract Infections;reverse genetics;Role;Rotavirus;Route;Salmonella;Salmonella typhi;Salmonella typhimurium;SARS coronavirus;SARS-CoV-2 inhibitor;SARS-CoV-2 spike protein;screening;Severe Acute Respiratory Syndrome;single-cell RNA sequencing;Sinus;small molecule inhibitor;socioeconomics;Spanish flu;Stomach;Surface;synergism;System;Terminal Bronchiole;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutic evaluation;three dimensional cell culture;Time;Tissue Engineering;Tissues;translational goal;Universities;vaccine development;Viral;Virulence;Virus;Virus Diseases;virus tropism;Zoonoses;zoonotic coronavirus


PI_NAMEs: KUO, CALVIN J (contact)

PROJECT_TERMS: 3-Dimensional;Applications Grants;Award;Biological Models;Biomimetics;Collaborations;Communicable Diseases;Communication;Communities;cost effectiveness;data management;data sharing;Dedications;Ensure;Enteral;Event;Fostering;Future;Goals;Human;Immunology;improved;in vitro Model;Information Dissemination;Infrastructure;Interdisciplinary Study;Leadership;lectures;meetings;member;Monitor;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;operation;Organoids;Performance;Productivity;programs;Publications;Quality Control;Reporting;Research;Research Institute;Research Personnel;Research Project Grants;Resources;respiratory;Schedule;Services;social media;sound;Subgroup;symposium;synergism;United States National Institutes of Health;Universities;web site

PROJECT_TITLE: Core A: Administrative Core


ADMINISTERING_IC: HS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative A stroke causes significant disruption in the ability of individuals to participate in functional activities that are associated with every-day living. Clinical guidelines recommend rehabilitation to address functional deficits, but the cost of that rehabilitation in skilled nursing and inpatient rehabilitation facilities is becoming increasingly unsustainable. The goal of this project is to examine whether a high intensity home-based rehabilitation approach can be successfully implemented and contribute to functional outcomes similar to those that are achieved in those costly facilities.

PI_NAMEs: JOHNSON, JOSHUA  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Evaluating the Implementation of High Intensity Home-Based Rehabilitation Following Stroke

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: LOUISVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF LOUISVILLE

ORG_STATE: KY

PHR: Project Narrative Loss of salivary gland function is a devastating condition. Millions of people lose salivary gland function from autoimmune disease or cancer radiation treatment, and therapies to promote gland repair are needed. Repair of salivary gland tissues requires re-growth of blood vessels that can support salivary gland tissue as it heals from damage.

PI_NAMEs: SANDELL, LISA L (contact)

PROGRAM_OFFICER_NAME: CHANDER, PREETHI

PROJECT_TERMS: Adipose tissue;angiogenesis;Angiogenesis Promoter;Autoimmune Diseases;Biological Models;Biology;Biopsy;Blood flow;blood vessel development;Blood Vessels;Cell Culture Techniques;cell type;Cells;Clinical;Complex;effective therapy;Endothelial Cells;Endothelium;Engineering;Ensure;Epithelium;Event;experience;FDA approved;Fibroblasts;Gene Expression;Genetic Transcription;Gland;Growth;healing;Implant;implantation;In Vitro;in vitro Assay;in vivo;Individual;Inflammation;Knowledge;knowledge of results;Malignant Neoplasms;Methods;Microbubbles;Molecular;Mus;Natural regeneration;novel;novel therapeutics;Organ;Pathology;Patients;Perfusion;Pericytes;Persons;Pharmaceutical Preparations;pharmacologic;Pilot Projects;Pre-Clinical Model;Production;Proliferating;Radiation therapy;Recovery;repaired;replacement tissue;Retinoids;Saliva;Salivary;Salivary Gland Tissue;Salivary Glands;Skin;small molecule;Smooth Muscle Myocytes;Source;Submandibular gland;success;Supporting Cell;System;Tazarotene;Testing;Therapeutic;therapeutic angiogenesis;Therapeutic Uses;Tissue Engineering;Tissues;Transplantation;Vascular Smooth Muscle;Vascularization;Vitamin A;wound;wound healing;Wound models

PROJECT_TITLE: Therapeutic vascularization to support repair of damaged salivary glands

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Lung

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Air;Alveolar;Alveolus;Bacterial Model;Biological Assay;Biomedical Engineering;Biomimetics;Cancer Model;cell type;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Communicable Diseases;Communication;Communities;Competence;Coronavirus;COVID-19 pandemic;CRISPR interference;CRISPR-mediated transcriptional activation;Development;Distal;Doctor of Philosophy;Drug Screening;Elements;empowerment;enteric pathogen;Epidemic;Epithelial Cells;Epithelium;experience;Experimental Models;Feedback;Funding;gastric organoids;gastrointestinal;Generations;Genetic;Genetic Engineering;genome sequencing;global health;Goals;health economics;Helicobacter pylori;high throughput screening;Histology;Human;Immune;immune activation;immune cell infiltrate;Immune response;Immunological Models;improved;In Vitro;in vitro Model;Infection;Infectious Agent;Infectious Diseases Research;Information Dissemination;innovation;Intestines;Liquid substance;Lung;Lung infections;Macrophage;Malignant Neoplasms;medical specialties;Methods;Middle East Respiratory Syndrome;Mission;Modeling;Modification;Mus;Mycoplasma;National Institute of Allergy and Infectious Disease;Nature;network models;next generation;Nose;novel;novel therapeutics;Occupational activity of managing finances;Organoids;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Physiological;Population;preservation;Process;Production;programs;Protocols documentation;Publications;Quality Control;Rapid screening;Reaction;reconstitution;Research;Research Personnel;Resources;respiratory;respiratory pathogen;response;Rotavirus;Rotavirus Infections;Salmonella typhi;Salmonella typhimurium;screening;Services;single-cell RNA sequencing;Sinus;Small Intestines;socioeconomics;Spanish flu;Standardization;stem cells;Stomach;Study models;success;synergism;System;Techniques;Terminal Bronchiole;Testing;Therapeutic;Tissues;tool;treatment response;whole genome

PROJECT_TITLE: Core B:  Organoid Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Women are twice as likely as men to experience psychiatric conditions involving dysregulation of emotional learning and memory, such as posttraumatic stress disorder and anxiety disorders. This project will test the novel hypothesis that this divergent vulnerability is conferred by female-specific engagement of a brain circuit that strengthens emotional memory. Elucidation of this circuit will lead to new gender-specific treatments for fear-based mental illness.

PI_NAMEs: LUCAS, ELIZABETH KATHLEEN (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Anxiety Disorders;Architecture;Auditory;biological sex;Brain;Cells;Chemosensitization;Classification;conditioning;Cues;Data;Disease;Disinhibition;effective therapy;Electrophysiology (science);emotion dysregulation;Emotional;emotional behavior;Emotions;Event;experience;experimental study;fear memory;Female;Fright;Gender;Generalized Anxiety Disorder;Genetic;Genetic Identity;Hippocampus;Hypothalamic structure;Impairment;In Vitro;in vivo;Individual;Knowledge;Lateral;Lateral Hypothalamic Area;Learning;Limbic System;Link;male;Maps;Medial;Mediator;Memory;memory encoding;memory process;men;Mental disorders;Methods;midbrain central gray substance;Modeling;Molecular;Molecular Profiling;neural circuit;neurobiological mechanism;Neurons;novel;optogenetics;Outcome;Panic Disorder;Patients;pharmacologic;Phobias;Post-Traumatic Stress Disorders;postsynaptic;pre-clinical;pre-clinical research;Predisposition;Prefrontal Cortex;Process;Quality of life;recruit;Regulation;resilience;response;Role;Severities;sex;Sex Differences;sexual dimorphism;showing emotion;Slice;Structure;Symptoms;Synapses;Testing;Therapeutic Intervention;therapeutic target;transcriptome;Translations;treatment strategy;Woman;women subjects;women versus men;Work

PROJECT_TITLE: A sex-specific circuit for emotional memory

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Clinical Research;Digestive Diseases;Genetics;Human Genome;Orphan Drug;Precision Medicine;Rare Diseases;Stomach Cancer;Uterine Cancer;Women's Health Research

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Thousands of patients with non-breast/non-gastric cancer have tumors bearing amplification or mutations in the receptor tyrosine kinase ERBB2/HER2, but lack effective, targeted treatment options. We hypothesize that the presence of HER2 genomic alterations increase the internalization rate of the receptor, a characteristic that can be exploited by a new class of therapeutics called antibody-drug conjugates (ADCs) to effectively treat these orphan diseases. In this proposal, we will utilize different preclinical models and samples from patients treated with anti-HER2 ADCs to uncover the biological variables that determine sensitivity to these agents, identify potential biomarkers for clinical responses, and determine whether irreversible HER2 kinase inhibitors such as neratinib can further enhance the efficacy of ADCs.

PI_NAMEs: CHANDARLAPATY, SARAT  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: Antibody-drug conjugates;Automobile Driving;Basic Science;biliary tract;Binding;Biological;Biopsy;Breast;cancer cell;cancer imaging;Cancer Patient;Cell Death Induction;cell free DNA;Cell Line;Cell model;Cell surface;Characteristics;Clinical;clinical predictors;Clinical Trials;cohort;Colon Carcinoma;Colorectal;combinatorial;Complex;Coupled;cytotoxic;Cytotoxic agent;Data;Data Correlations;data integration;Dependence;Development;digital;Dimerization;Disease Progression;DNA Sequence Alteration;dosage;efficacious treatment;Endocytosis;Endometrial Carcinoma;Enrollment;Epidermal Growth Factor Receptor;ERBB2 gene;ERBB3 gene;Evolution;exome sequencing;Fc Receptor;Fluorescence Resonance Energy Transfer;Fluorescent in Situ Hybridization;gastroesophageal cancer;Gene Amplification;genome sequencing;Genomics;Head and Neck Cancer;Heterodimerization;Histology;Homodimerization;Hyperactivity;Image;Immunohistochemistry;In Vitro;in vivo;inhibitor;insight;Institution;kinase inhibitor;Leadership;Lung;Lung Neoplasms;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of urinary bladder;Malignant Neoplasms;malignant stomach neoplasm;Mass Spectrum Analysis;Mediating;Membrane;Modeling;Molecular;mutant;Mutation;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;Organoids;overexpression;participant enrollment;patient derived xenograft model;Patient Monitoring;patient population;patient stratification;Patients;PET/CT scan;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Positioning Attribute;potential biomarker;Pre-Clinical Model;predicting response;Proteins;proteomic signature;Proteomics;Rare Diseases;receptor;receptor binding;receptor expression;Receptor Protein-Tyrosine Kinases;Resistance;response;response biomarker;Role;Salivary duct structure;Sampling;Schedule;Slice;Solid Neoplasm;standard of care;success;targeted exome sequencing;targeted treatment;Techniques;Testing;Therapeutic;Time;Tissues;Toxic effect;trafficking;transcriptomics;Translating;Trastuzumab;Treatment Protocols;treatment response;tumor;Tumor Biology;tumor heterogeneity;tumorigenesis;Ubiquitination;Variant;Xenograft procedure

PROJECT_TITLE: HER2-mediated delivery of cytotoxic agents in solid tumors

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: INDIANAPOLIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Sports-related concussion is a significant public health problem with approximately two to four million injuries occurring each year in the United States of America. Novel neuroimaging techniques play a critical role in elucidating underlying pathophysiological changes of the brain and serve as noninvasive markers for brain injury and recovery. The goal of this project is to advance clinical utility of novel neuroimaging methods via individualized analytic approaches.

PI_NAMEs: HAREZLAK, JAROSLAW ;WU, YU-CHIEN  (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Acute;Address;Affect;analytical method;Anatomy;Animal Model;Area;Assessment tool;Autopsy;Axon;axon injury;Biological;Biomechanics;Brain;Brain Concussion;Brain Injuries;Centers for Disease Control and Prevention (U.S.);Characteristics;chronic traumatic encephalopathy;Classification;Clinical;Clinical assessments;Clinical Management;Cohort Studies;college;Data;Databases;density;Diffuse Axonal Injury;Diffusion;Diffusion Magnetic Resonance Imaging;Disease Pathway;Education;Functional disorder;Future;Goals;head impact;Heterogeneity;high risk;high school;Human;Image;Impaired cognition;in vivo;Individual;individual variation;injured;Injury;injury recovery;Maps;Measures;Methods;Microscopic;mild traumatic brain injury;Minority;Modernization;Multimodal Imaging;Nature;Nervous System Disorder;Neurites;neurobiological mechanism;Neurodegenerative Disorders;neuroimaging;neuropathology;novel;Outcome;Outcome Measure;Pathologic;Pathology;Pathway interactions;Pattern;Persons;Phenotype;Physiological;Play;psychological distress;Public Health;Recovery;Reporting;Research;Role;Sampling;Severities;Signs and Symptoms;Spatial Distribution;Specificity;Sports;Standardization;Structure;Subgroup;Symptoms;Techniques;Time;tool;Traumatic Brain Injury;United States;white matter;white matter change

PROJECT_TITLE: Comprehensive White-matter Microstructure-informed Analytical Methods to Elucidate Neurobiological Mechanisms of Sports-related Concussion (SRC)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: The set of genes that cause Alzheimer’s disease (AD) are still far from clear. We have established a novel pipeline to quantify the contribution of tandem repeats throughout the human genome and have identified several repeats with AD-specific repeat expansions. We propose to interrogate the contribution of these repeats to disease pathogenesis and their mechanism of action.

PI_NAMEs: VALDMANIS, PAUL NILS (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: African American;Age;Alzheimer's Disease;Alzheimer's disease risk;Amyotrophic Lateral Sclerosis;Back;Base Sequence;Biological Models;Biology;causal variant;Cells;cohort;Complement;Data;Data Set;Dementia;Disease;disease-causing mutation;DNA;Ethnic Population;experimental study;General Population;Genes;Genetic;Genetic Risk;Genome;genome wide association study;genome-wide;global health;Goals;Haplotypes;Heterozygote;Hispanic;Human;Human Genome;Individual;insight;Introns;Lead;Length;Maps;Methods;Minisatellite Repeats;Molecular;multi-ethnic;multiple omics;Nervous System Disorder;Neurodegenerative Disorders;neurogenetics;NID gene;Not Hispanic or Latino;novel;novel strategies;novel therapeutics;Nucleic Acid Regulatory Sequences;Nucleotides;Outcome;Pathogenesis;Pathogenicity;Patients;Play;Population;Positioning Attribute;promoter;Property;Qualifying;Reporting;risk variant;RNA-Binding Proteins;Role;Sampling;sex;Site;Structure;Tandem Repeat Sequences;Techniques;Technology;Testing;Validation;Variant;WD Repeat;whole genome;Work

PROJECT_TITLE: Novel approaches to identify tandem repeat expansions in neurodegenerative disease

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


PHR: NARRATIVE Our HOME program is designed to be directly responsive to the Understanding HIV Reservoir Dynamics RFA (RFA-AI-21-013) to define how HIV colonizes, establishes, and moves within and across reservoirs with different immune, cell, epigenetic and HIV drug environments. This program will provide new knowledge on the fundamental viral and host mechanisms driving HIV reservoir dynamics and identify the vulnerabilities in the activity and renewal of HIV reservoirs across the human body that can be targeted by new HV cure efforts.

PI_NAMEs: SMITH, DAVID MITCHELL (contact)

PROGRAM_OFFICER_NAME: NOVAK, LEIA KAYE

PROJECT_TERMS: Acute;Altruism;analytical method;Anatomy;Animal Model;antiretroviral therapy;Architecture;Automobile Driving;Autopsy;Behavior assessment;Binding;biobank;Blood;CD4 Positive T Lymphocytes;Cells;Cessation of life;Clinical;Clinical Data;Clonal Expansion;cohort;Communication;Complex;Data;data integration;data management;decay acceleration;design;Enrollment;Environment;Environmental Risk Factor;Epigenetic Process;Ethics;Family;flexibility;Genetic Transcription;Genome;Gifts;grasp;HIV;HIV Infections;Home;Hour;Human;Human body;Image;Immune;Immunologics;Immunology;Infrastructure;innovation;insight;Integration Host Factors;Interruption;Knowledge;latent HIV reservoir;Leadership;Metaphor;Methods;Mission;multidimensional data;new technology;novel;novel therapeutics;Nucleic Acids;Outcome;outreach;pandemic disease;Participant;Pathology;Persons;Pharmaceutical Preparations;Plasma;Population;Population Dynamics;Predisposition;prevent;Process;programs;Proteins;Proviruses;Research;Research Project Grants;Resources;sample collection;Sampling;Services;Social Behavior;Source;Specific qualifier value;Specimen;success;Technology;Time;Tissues;Viral;Viremia;virology;Virus Integration;Virus Latency;Virus Replication

PROJECT_TITLE: Leaving, Coming, and Staying HIV Obligate Microenvironments (HOME)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Although genetic studies of complex human traits have been tremendously successful in identifying thousands of genomic risk regions that harbor variants increasing risk, Unfortunately, the vast majority include individuals of European ancestry making the transferability to individuals with mixed ancestries (e.g., African Americans) challenging. In this proposal we develop and apply new statistical and experimental methods to build admixture-aware polygenic risk scores for complex traits. We leverage a unique data set of >230,000 admixed individuals whose genotypes are linked to electronic health records to develop and calibrate PRS in admixed populations.

PI_NAMEs: KENNY, EIMEAR ELIZABETH;LANGE, LESLIE A;PASANIUC, BOGDAN  (contact)

PROGRAM_OFFICER_NAME: MINEAR, MOLLIE A

PROJECT_TERMS: Acceleration;Address;Admixture;African American population;African ancestry;Americas;Asian ancestry;Awareness;Benchmarking;biobank;Calibration;causal variant;Clinical Data;cohort;Cohort Studies;Colorado;Complex;Data;data harmonization;data integration;Data Set;Databases;Development;digital health;Disease;disease natural history;East Asian;Electronic Health Record;empowerment;Environmental Risk Factor;Epidemiology;Equity;Ethnic Origin;European;European ancestry;Event;Gene Expression;Genetic;genetic architecture;Genetic Determinism;Genetic Drift;Genetic Models;Genetic study;Genetic Variation;Genome;genome-wide;genomic data;Genomic medicine;Genomics;Genotype;health data;health equity;health management;Health system;Heterogeneity;Hispanic Americans;Human;improved;Incidence;Individual;interest;Jackson Heart Study;Link;Location;Longitudinal cohort;Maps;Medical;Medicine;Methods;Mexican Americans;migration;Modeling;Molecular;mosaic;novel;Participant;patient population;Patient Self-Report;phenotypic data;polygenic risk score;Population;population based;Population Genetics;portability;pressure;Process;Proxy;Puerto Rican;Race;Relative Risks;Research;Risk;Risk Factors;Sample Size;Slave;social health determinants;Socioeconomic Status;Source;Statistical Methods;Structure;System;Testing;tool;trait;transcriptome;Uncertainty;urban setting;Variant;World Health

PROJECT_TITLE: PRS Center for Admixed Populations and Health Equity (CAPE)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Cancer;Coronaviruses;Digestive Diseases;Digestive Diseases - (Peptic Ulcer);Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Stomach Cancer;Vaccine Related

PI_NAMEs: AMIEVA, MANUEL R (contact)

PROJECT_TERMS: 3-Dimensional;adaptive immune response;Address;Adult;Affect;Air;Animals;Antibiotic Resistance;Apical;Bacteria;Biomimetics;Cancer Etiology;Cell Differentiation process;Cell surface;Cells;Cessation of life;Chronic;colonization resistance;Comparative Study;Confocal Microscopy;CRISPR/Cas technology;Data Set;Disease;Disease Progression;Epithelial Cells;Epithelium;Exposure to;Feedback;Gastric Glands;gastric organoids;Gastroenteritis;gastrointestinal;gastrointestinal epithelium;Gene Modified;Generations;genetic manipulation;Genetic Screening;Gland;Growth;Helicobacter Infections;Helicobacter pylori;Human;human tissue;Imaging Techniques;Immune;immune activation;Immune response;Immune system;Infection;Inflammation;Inflammatory;Information Dissemination;Innate Immune Response;intestinal epithelium;Intestines;Invaded;Liquid substance;live cell imaging;Lung;M cell;malignant stomach neoplasm;Methods;Modeling;Molecular;Mucosal Immune System;Mucositis;Mucous body substance;Mucous Membrane;mutant;novel;Occupational activity of managing finances;Organoids;pathogen;pathogenic bacteria;Pathologic;Pathway interactions;Peptic Ulcer;permissiveness;Persons;Population;preservation;Public Health;Reporter;Reporting;Research;Resistance;Resolution;Resources;response;Risk Factors;Role;Salmonella;Salmonella enterica;Screening procedure;Side;single-cell RNA sequencing;Site;socioeconomics;Stains;stem cells;Stomach;Surface;Suspension Culture;Suspensions;Swimming;synergism;targeted treatment;Technology;Testing;Therapeutic;Tissue Engineering;tool development;Typhoid Fever;vaccine strategy;Vaccines;Virulence Factors;Virus

PROJECT_TITLE: Project 1: Biomimetic Interactions Between Bacterial Pathogens and the Gastrointestinal Epithelium


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases;Kidney Disease

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: The future of medical progress depends on the translation of advances from the bench to the bedside, and an interdisciplinary approach to complex problems. The continuation of these meritorious goals, captured in this training proposal, will help assure that a diverse and highly- trained workforce is available in the future to carry out important biomedical and translational research.

PI_NAMEs: DEFRANCO, DONALD B;JURCZAK, MICHAEL J.;KLEYMAN, THOMAS R (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Area;Basic Science;Biology;Biomedical Research;career;Cellular biology;clinical investigation;design;Diabetes Mellitus;Digestive System Disorders;Endocrine;Endocrinology;Epithelial Cells;Epithelium;experience;Faculty;Fostering;Goals;interest;Investigation;Kidney;kidney cell;Liver diseases;medical schools;Medical Students;member;Mentors;Metabolism;programs;Qualifying;Research;Research Training;role model;Scientific Inquiry;Students;summer research;Training;Training Programs;Universities

PROJECT_TITLE: Training in Renal, GI, Endocrine and Epithelial Biology

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Cancer is a leading cause of death in the United States, and this study seeks to identify novel vulnerabilities of a class of particularly lethal tumors, including glioblastoma and prostate cancer. When cancers delete the tumor suppressor gene PTEN, they frequently co-delete a neighboring gene called ATAD1, which is important for mitochondrial protein quality control. We will investigate how loss of ATAD1 may make cancers more likely to activate intracellular signaling pathways that result in cell death, and how this trait could be targeted in cancer therapy.

PI_NAMEs: WINTER, JACOB MICHAEL (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: 10q;Affect;Animal Model;Apoptosis;Apoptotic;ATP phosphohydrolase;Back;BCL2 gene;BCL2L11 gene;BH3 peptide;Biochemistry;cancer cell;Cancer Patient;cancer therapy;career;Cause of Death;Cell Culture System;Cell Death;Cell Fractionation;cell growth;Cell Line;Cell Proliferation;Cell Respiration;Cell Survival;Cells;Cellular biology;Chromosome 10;Chromosomes;Clinical;clinical development;clinical training;Communities;CRISPR screen;CRISPR/Cas technology;Dedications;del(10q23);Dermatology;Development;Diagnosis;DNA;Drug Targeting;experience;Family member;fitness;Fluorescence Microscopy;Gene Deletion;Genes;Genetic;genome-wide;Genomics;Glioblastoma;Homeostasis;Human;Impairment;In Vitro;in vivo;Individual;Induction of Apoptosis;Length;Light;Malignant neoplasm of prostate;Malignant Neoplasms;Mammalian Cell;Measures;medical specialties;Melanoma;Metastatic Prostate Cancer;mimetics;Mitochondria;Mitochondrial Proteins;mouse model;Mus;Mutation;new therapeutic target;Normal Cell;novel;novel therapeutic intervention;Null Lymphocytes;Outer Mitochondrial Membrane;Patients;Pharmaceutical Preparations;Phosphoric Monoester Hydrolases;Physicians;precision oncology;Predisposition;prevent;Process;professor;Prognosis;Proteins;PTEN gene;Quality Control;Regulation;Research;Research Personnel;Research Training;Resolution;Role;Scientist;Sequence Deletion;Signal Pathway;skills;small molecule;Synthetic Genes;System;Tail;Talents;Testing;Therapeutic;Training;trait;Transmembrane Domain;tumor;tumor progression;Tumor Suppressor Genes;United States;Universities;Utah;Xenograft procedure

PROJECT_TITLE: Mitochondrial quality control as a selective vulnerability in cancers with chromosome 10q deletion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-U(20)L]


NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Activation of brown adipose tissue (BAT) increases energy expenditure and facilitates futile cycling of fuels including glucose, fatty acids and amino acids, thereby improving energy and glucose homeostasis. Together with the beneficial effects of BAT on cardiometabolic health, studies in humans and in rodents made BAT a subject of research efforts to understand and treat obesity and related disorders. However, while BAT is composed of heterogenous adipocyte populations, the understanding of adipocyte heterogeneity and its significance in metabolic physiology and disease has been limited. The results obtained from this study will reveal the physiological function of a distinct adipocyte subpopulation in whole-body energy and glucose metabolism, leading to the identification of poteintial therapeutic target for the treatment of obesity and its associated metabolic diseases.

PI_NAMEs: LIU, MEILIAN  (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Ablation;adipocyte differentiation;Adipocytes;Adipose tissue;Adult;Aging;Amino Acids;Area;Biogenesis;Biological;Biological Assay;Biology;blood glucose regulation;Brown Fat;cardiometabolism;Cell Differentiation process;Cell Proliferation;Cell Separation;Cells;Development;diet-induced obesity;Diphtheria Toxin;Disease;Energy Metabolism;ERR1 protein;Exhibits;Family;Fatty Acids;Foundations;Futile Cycling;Genes;Glucose;glucose metabolism;Health;Heterogeneity;Homeostasis;Human;Immune response;improved;insight;Insulin Resistance;Knowledge;Link;lipid biosynthesis;Lipids;Lipolysis;Maintenance;Mediating;member;Metabolic;Metabolic Diseases;Metabolism;Mitochondria;Modeling;mouse model;Mus;novel;Obesity;obesity treatment;Oxidative Phosphorylation;Pathway interactions;Physiological;Physiology;Play;Population;precursor cell;Regulation;Research;Research Subjects;response;Rodent;Role;single nucleus RNA-sequencing;Solid;stem cells;Stimulus;Testing;therapeutic development;therapeutic target;Thermogenesis;Tissues;transcription factor;Transcription Factor AP-1;Transcriptional Regulation;uncoupling protein 1;Vascularization

PROJECT_TITLE: Transcriptional Control of High-thermogenic Adipocyte Development

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Digestive Diseases;Genetics;Infectious Diseases

ORG_STATE: CA

PI_NAMEs: GREENBERG, HARRY BERNARD (contact)

PROJECT_TERMS: Acute;Adult;Age;Air;Animals;Antigen Presentation;Apical;attenuation;Binding;Biology;Biomimetics;Biopsy;Cell Communication;Cell Physiology;Cell surface;Cells;Cessation of life;Child;Colon;Communication;Coronavirus;Coronavirus Infections;CRISPR screen;CRISPR/Cas technology;Crystallography;cytokine;Data;Dependence;Development;Diarrhea;diarrheal disease;Disabling;Disease;Double-Stranded RNA;Elderly;Enteral;enteric infection;enteric pathogen;Enterocytes;Epithelial Cells;Epithelial Receptor Cell;Epithelium;Escape Mutant;Generations;Genes;Genetic;Genetic Determinism;Genetic Variation;Genome;genome-wide;Goals;Hospitalization;HT29 Cells;Human;human model;human monoclonal antibodies;ileum;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;In Vitro;Infant;Infection;Inflammatory Bowel Diseases;Information Dissemination;Innate Immune Response;interest;Interferons;intestinal epithelium;Intestines;Knock-out;Libraries;Licensing;Life;Liquid substance;M cell;Mediating;method development;microbial;Modeling;Monoclonal Antibodies;Morphology;mouse model;Mucous Membrane;Mus;Natural Immunity;neutralizing monoclonal antibodies;novel;Occupational activity of managing finances;Organoids;Outpatients;pathogen;Pathogenesis;Peyer's Patches;pharmacologic;Population;Predisposition;prevent;Process;Production;Productivity;programs;Proteins;rational design;Recombinants;Recovery;Regulation;Research;respiratory virus;response;reverse genetics;Role;Rotavirus;Rotavirus Infections;Rotavirus Vaccines;Salmonella typhi;Seminal;SH2D3A gene;Signal Transduction;single-cell RNA sequencing;Site;Small Intestines;STAT1 gene;success;suckling;Surface;synergism;System;Technology;tool;transcriptome;transcriptome sequencing;transcytosis;Vaccines;Viral;Viral Pathogenesis;Virus;Visit;Work

PROJECT_TITLE: Project 2: Regulation of Rotavirus Host Range, Neutralization, and M cell Interactions in Enteric Biomimetics


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Periodontitis is a prevalent oral inflammatory disease that leads to destruction of the tooth-supporting tissues and has a significant public health impact and economic burden. Interleukin-22 is a functionally versatile cytokine which mediates one-way communication from immune cells to tissues and specifically it regulates inflammation, stem cell function and tissue regeneration. This project investigates the precise role of IL-22 in periodontitis aiming to develop IL-22-targeted autotherapies that can promote periodontal health.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS  (contact)

PROJECT_TERMS: Address;Alveolar Bone Loss;Biological;Biological Process;biological systems;bone;bone loss;Bone Regeneration;Cells;Chronic;Communication;cytokine;Data;design;Disease;dysbiosis;Economic Burden;Enzymes;experimental study;Fibroblasts;fighting;Genes;Gingiva;Health;Homeostasis;host microbiome;Human;IL17 gene;Immune;Immune response;Immune system;Immunity;Immunologic Surveillance;immunoregulation;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inhibitor;interleukin-22;Intervention;Intervention Studies;MAPK3 gene;Mediating;Mesenchymal Differentiation;Mesenchymal Stem Cells;Microbe;microbial;microbiome alteration;Mus;Natural regeneration;Nature;novel;Oral;Osteogenesis;osteogenic;Pathogenesis;Patients;Periodontal Diseases;Periodontal Ligament;Periodontitis;Periodontium;Phase;Play;Proliferating;Public Health;receptor;regenerative;repaired;Research;Resolution;response;Role;Series;Signal Transduction;Stat3 protein;stem cell function;Stress;Stromal Cells;synergism;System;therapeutic target;Tissue Preservation;tissue regeneration;tissue repair;Tissues;Tooth structure

PROJECT_TITLE: IL-22, Immune Plasticity, and Autotherapy in the Periodontium


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: SANTA BARBARA

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Health relevance. Many important drugs suffer from dose-limiting toxicity. The long-term goal of this project is to enable wearable molecular monitors supporting the convenient measurement of these drugs, ensuring their safer, more effective delivery.

PI_NAMEs: KIPPIN, TOD EDWARD;PLAXCO, KEVIN W (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Animal Model;Antibiotics;antimicrobial;aptamer;Area Under Curve;Biological Markers;Biomedical Research;Blood;Blood Glucose;Brain;Cerebrospinal Fluid;Chemicals;Clinical;clinical decision-making;Clinical Pharmacology;clinical practice;clinically relevant;Complex;Continuous Glucose Monitor;cost effective;Dangerousness;detector;Diabetes Mellitus;Dose;Dose Limiting;Drug Delivery Systems;drug disposition;drug efficacy;Drug Exposure;Drug Kinetics;drug metabolism;Drug Monitoring;Drug Transport;Elements;Ensure;Feedback;Funding;Goals;Grant;Health;Immunosuppressive Agents;improved;In Situ;in vivo;in vivo monitoring;infectious disease treatment;innovation;insight;Intestines;Intravenous;Knowledge;Lead;Liquid substance;Measurement;Measures;Metabolic;minimally invasive;Molecular;Monitor;Outcome;Patients;Pharmaceutical Preparations;Pharmacology Study;Plasma;Precision therapeutics;Property;Rattus;Regimen;Reporting;Research;Resolution;Safety;sensor;Sex Differences;Solid;Specificity;standard of care;stem;subcutaneous;Surveys;Technology;temporal measurement;Therapeutic;Therapeutic Index;Time;Tissues;tool;Toxic effect;Variant;Venous;wearable device;Women's Health;women's outcomes

PROJECT_TITLE: Bio-electrochemical detectors for in vivo continuous monitoring

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Cocaine;Drug Abuse (NIDA only);Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE The goal of this program is to attract talented undergraduate students into careers in the biomedical sciences, particularly in fields relevant to the mission of the National Institute of Drug Abuse. This is expected to increase the supply of qualified investigators who are studying substance use disorders, as well as contribute to overall science literacy by equipping students with appropriate science skills and an appreciation for biomedical research.

PI_NAMEs: LAVIN, ANTONIETA  (contact)

PROGRAM_OFFICER_NAME: FRIEND, LINDSEY NICOLE

PROJECT_TERMS: addiction;Address;Affect;aged;Alcohol abuse;alcohol research;American;animal imaging;Appointment;Area;Attitude;Award;Basic Science;Biochemistry;biomedical imaging;Biomedical Research;career;Clinical Sciences;clinically relevant;Cocaine Dependence;cocaine relapse;Complement;Country;Data;Development;doctoral student;Drug abuse;Drug Addiction;Drug usage;Education Projects;education research;Educational Grants;Educational process of instructing;Environment;Evaluation;experience;Exposure to;Faculty;faculty mentor;Family;Fostering;Friends;Funding;Gender;Goals;Graduate Education;Health;Home;Human;human imaging;illicit drug use;Institution;interest;Knowledge;Laboratories;Learning;lectures;literacy;Measures;Medical;Medical Research;Mentored Clinical Scientist Development Program;Mentors;Methamphetamine dependence;Mission;Molecular Biology;National Institute of Drug Abuse;Nature;Neurobiology;Neurosciences;next generation;novel strategies;Opiate Addiction;Oral;Outcome;Postdoctoral Fellow;pre-doctoral;Professional Education;programs;Psychiatry;Qualifying;Radiology Specialty;Reporting;Request for Applications;Research;Research Ethics;research faculty;Research Personnel;Research Project Grants;Research Support;Research Technics;Research Training;responsible research conduct;Scholars Program;Science;scientific literacy;Series;sex;skills;social;Social Functioning;societal costs;Societies;South Carolina;Stress;Structure;student participation;Students;Substance abuse problem;substance use;Substance Use Disorder;summer research;Surveys;Talents;Thinking;Training;Training and Education;training opportunity;Training Programs;Translational Research;treatment research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Summer Undergraduate Research Program in Neuroscience of Addiction


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE A subset of adult and pediatric leukemias has rearrangements of the AF10 gene, which are associated with dismal survival outcomes. However, there are no clinically effective therapies targeting the rearranged AF10 gene. The overall objective of this application is to uncover mechanisms of oncogenesis in acute myeloid leukemia with AF10 gene rearrangements using genetic, proteomic and pharmacological approaches, which could lead to newer and safer targeted therapies.

PI_NAMEs: DESHPANDE, ANIRUDDHA J. (contact)

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: acute lymphoblastic leukemia cell;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Acute T Cell Leukemia;Address;Adult;adult leukemia;Antiparasitic Agents;atovaquone;biobank;Biochemical;Bone Marrow;cancer cell;cancer cell differentiation;Cancer Etiology;Cell Line;Cells;Chemoresistance;Child;Childhood;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Chimeric Proteins;Clinical;Clinical Trials;clinically relevant;clinically significant;cohort;Combined Modality Therapy;CRISPR screen;Custom;cytokine;Cytokine Signaling;Data;Data Analyses;Dependence;Disease;effective therapy;efficacious treatment;efficacy testing;epigenomics;Event;Failure;Functional disorder;functional genomics;Fusion Oncogene Proteins;Gene Activation;Gene Expression;Gene Fusion;Gene Rearrangement;Genes;Genetic;Genetic Transcription;Genomics;Growth Factor;Hematopoietic;high risk population;Homeobox Genes;Human;human model;Hyperactivity;Impairment;In Vitro;in vivo;Incidence;Inflammatory;inhibitor;JAK1 gene;Janus kinase;leukemia;leukemia treatment;leukemogenesis;Libraries;Link;Malignant Childhood Neoplasm;Mediating;Methodology;Methods;Modeling;Molecular;mortality;mouse model;Mus;Mutation;new therapeutic target;novel;Oncoproteins;Outcome;Pathogenesis;Pathway interactions;patient derived xenograft model;Patients;Pediatric cohort;Pharmaceutical Preparations;pharmacologic;Pre-Clinical Model;preclinical study;Prevalence;Process;prognostic;Proteomics;Recurrence;Recurrent disease;Refractory;Relapse;Resistance;Role;Sampling;self-renewal;Series;side effect;Signal Transduction;STAT3 gene;stem cell self renewal;survival outcome;targeted treatment;Testing;Tetracyclines;Therapeutic;Toxic effect;transcription factor;Transcriptional Activation;transcriptomics;treatment response;treatment strategy;tumorigenesis;Xenograft procedure

PROJECT_TITLE: Molecular Pathogenesis of AF10-Rearranged Leukemias

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


PHR: Relevance to public health We are developing a suite of technologies to facilitate the clinical adoption of nondestructive 3D pathology. By developing automated tissue-preparation systems, a novel multi-scale 3D microscopy device, and volumetric macro-dissection apparatus, this project will enable future studies to demonstrate the value of 3D pathology for patient diagnosis, prognostication, and personalized treatments.

PI_NAMEs: LIU, JONATHAN T.C. (contact)

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: 3-Dimensional;Adoption;analog;Anatomy;Antibodies;Architecture;aspirate;Benchmarking;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Cells;Clinical;clinical decision support;Clinical Research;commercialization;Costs and Benefits;Data;deep sequencing;design;Development;Devices;Diagnosis;Diagnostic;Disease;Dissection;DNA;Excision;Fluorescent Dyes;Formalin;Funding Agency;Future;Generations;Genomics;Glass;Healthcare;Histology;Histopathology;human tissue;Hybrids;Image;image guided;imaging modality;Imaging technology;Immersion;improved;indexing;innovation;Institution;instrumentation;Kidney Diseases;Label;Licensing;Light;lightspeed;Malignant - descriptor;Malignant Neoplasms;Methods;Microfluidics;Microscope;Microscopy;molecular diagnostics;Motivation;Neurodegenerative Disorders;novel;Nucleic Acids;Operative Surgical Procedures;Optics;Paraffin Embedding;Pathologic;Pathologist;Pathology;Pathway interactions;Patients;Performance;personalized medicine;Precision therapeutics;Prediction of Response to Therapy;Preparation;Process;prognostic;prognostication;Protocols documentation;prototype;Public Health;Publishing;Refractive Indices;Reproducibility;Research Personnel;Resolution;Sampling;sequencing platform;Services;Slide;Specimen;Speed;Stains;Standardization;Structure;System;Techniques;Technology;Thick;Three-Dimensional Image;tissue preparation;Tissue Sample;Tissues;tool;translational impact

PROJECT_TITLE: Instrumentation platform for 3D pathology with open-top light-sheet microscopy

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases

PHR: Project Narrative Esophageal cancer rates are increasing in the United States, and surveillance of Barrett’s esophagus (BE) may prevent esophageal cancer. I propose to develop and evaluate an artificial intelligence algorithm capable of diagnosing cancer within BE at the time of endoscopy using confocal high-resolution microendoscopy (cHRME), a novel technology capable of cellular imaging of the esophagus. This algorithm would provide an immediate, accurate computer-assisted diagnosis, which would allow this technology to be widely used during BE surveillance in community and low-resource settings with substantial public health impact.

PI_NAMEs: TAN, MIMI CHANG (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Age;Agreement;Algorithmic Software;Algorithms;Architecture;Area;Artificial Intelligence;artificial intelligence algorithm;automated algorithm;Barrett Esophagus;Bioinformatics;Biopsy;Blood Vessels;Calibration;Cancer Detection;cancer diagnosis;career development;Categories;cellular imaging;Classification;classification algorithm;Clinical;clinical risk;Clinical Trials;clinically relevant;Communities;community setting;Computer Assisted;Computer-Assisted Diagnosis;cost;cost effective;curative treatments;Data;Detection;Development;Development Plans;Devices;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;Discrimination;Dysplasia;Early Diagnosis;Early treatment;Endoscopes;Endoscopy;Epidemiology;Esophageal Adenocarcinoma;Esophageal mucous membrane;Esophageal Neoplasms;Esophagus;Ethnic Origin;Evaluation;experience;Funding;Future;Goals;High grade dysplasia;Histopathology;Image;Image Analysis;Imaging technology;Incidence;indexing;Interview;K-Series Research Career Programs;Learning;Length;Lesion;Life Style;Light;Longitudinal Studies;Machine Learning;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Measures;men;Mentors;Methodology;microendoscope;microendoscopy;Microscopic;Modeling;Neoplasms;neoplastic;new technology;novel;Nuclear;Obesity;Optical Biopsy;Patients;Performance;portability;Positioning Attribute;prevent;prospective;Public Health;Qualitative Research;Quality-Adjusted Life Years;Race;Recommendation;Recording of previous events;recruit;Research;research and development;Research Personnel;Research Training;Resolution;Resource-limited setting;Risk;Risk Assessment;Risk Factors;risk prediction model;risk stratification;ROC Curve;Screening for cancer;sex;Site;Smoking;Specificity;Structure;Tablet Computer;Techniques;Technology;technology development;Time;United States;Validation;Work

PROJECT_TITLE: Development and Validation of an Automated Algorithm for Real-time Detection of Neoplasia in Barrett's Esophagus using a Low-cost, Portable Microendoscope

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases

PI_NAMEs: BARIC, RALPH S (contact)

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Acute Respiratory Distress Syndrome;adaptive immune response;Air;airway epithelium;antagonist;Apical;biomarker panel;Biomimetics;cell type;Cessation of life;China;Chiroptera;Chronic Disease;Code;Confocal Microscopy;Coronavirus;Coronavirus Infections;Country;COVID-19;COVID-19 pandemic;COVID-19 therapeutics;Data;Disease;Enteral;enteric pathogen;Epidemic;epidemic potential;Epithelium;Future;global health;Glycoproteins;Goals;Growth;Heart Arrest;high throughput screening;high-throughput drug screening;Human;human disease;human model;human tissue;Imaging Techniques;Immune;immune activation;improved;In Vitro;in vivo;Infection;Inflammatory;inhibitor;Innate Immune Response;insight;intestinal epithelium;Intestines;Liquid substance;live cell imaging;Lung;lung development;Lung Diseases;Lung infections;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;mouse model;Mucous Membrane;Multisystem Inflammatory Syndrome in Children;Mus;mutant;new epidemic;novel coronavirus;nucleoside inhibitor;Organ;Organoids;pandemic disease;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Play;Pneumonia;Primary Cell Cultures;Primary Infection;Reagent;Reporting;Research;Resolution;Resources;response;Risk;Role;SARS coronavirus;SARS-CoV-2 infection;SARS-CoV-2 inhibitor;screening;Severe Acute Respiratory Syndrome;Signal Transduction;single-cell RNA sequencing;small molecule inhibitor;Stroke;success;Surface;Syndrome;synergism;System;Technology;Therapeutic;Tissue Engineering;Tissues;TMPRSS2 gene;Tropism;Viral Pathogenesis;Virus;Virus Diseases;virus host interaction;Virus Replication;virus tropism;Work;zoonotic coronavirus

PROJECT_TITLE: Project 3: SARS CoV-2 Lung Organoid Interactions in Replication and Pathogenesis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: Huntington

ORG_NAME: MARSHALL UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative The proposed research is relevant to public health because nicotine addiction remains the number one cause of preventable death. The high concentration of nicotine, different nicotine formulations, and addition of flavors to only electronic cigarettes may exacerbate nicotine addiction and increase risks for nicotine-related diseases and disorders. Understanding the neurobiological and neurophysiological changes specific to these unique constituents will dramatically increase our understanding of their role in nicotine addiction and risks toward lifelong addictions to nicotine.

PI_NAMEs: HENDERSON, BRANDON JARROD (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: addiction;Addictive Behavior;Address;Adolescent;American;Antibodies;base;Basic Science;Behavior;Behavioral;Biological Assay;Biological Models;Brain;brain cell;Brain region;cell type;Cells;combustible cigarette;Communities;Data;Devices;Disease;Dopamine;dopaminergic neuron;Dose;Drosophila acetylcholine receptor alpha-subunit;Electrochemistry;Electronic cigarette;electronic liquid;Electronic Nicotine Delivery Systems;electronic vape;Electrophysiology (science);Exhibits;Face;Flavoring;Fluorescence Microscopy;Formulation;Generations;Goals;high risk population;Human;in vivo Model;innovation;interest;Knowledge;Link;Measures;Menthol;Methods;Modeling;mouse model;Mus;National Institute of Drug Abuse;Neurobiology;neuronal excitability;neurophysiology;neurotransmission;Nicotine;Nicotine Dependence;nicotine reward;nicotine self-administration;nicotine use;novel;Outcome;patch clamp;Pathway interactions;Periodicity;Policies;Population;Prefrontal Cortex;prenatal;preventable death;Psychological reinforcement;Public Health;Research;Rewards;Risk;Role;Salts;Scanning;Self Administration;Smoker;smoking initiation;Sodium Chloride;success;System;Testing;tobacco products;Up-Regulation;vaper;vaping;vapor

PROJECT_TITLE: Electronic cigarettes, adolescents, and changes in neurobiology

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Cancer;Immunotherapy

PHR: Project narrative Although cancer immunotherapy has revolutionized the treatment of advanced cancers, it only benefits patients with immunologically “hot” tumors, partly because we have not taken advantage of anti-cancer innate immunity. We recently identified cGAMP as a key danger signal that cancer cells send to our innate immune system in response to intrinsic DNA damage, and we have also uncovered how cancers overcome this detection by overexpressing the enzyme that degrades this signal. Here we propose to fully characterize the effects of extracellular cGAMP on cancer development and to develop strategies to selectively prevent its degradation in tumors, with the goal of identifying targeted anti-cancer immunotherapies with minimal side effects.

PI_NAMEs: STRAIGHT, AARON F (contact)

PROGRAM_OFFICER_NAME: MERCER, NATALIA

PROJECT_TERMS: Ablation;Address;Advanced Malignant Neoplasm;analog;anti-cancer;anti-tumor immune response;antitumor effect;Atlas of Cancer Mortality in the United States;ATP Hydrolysis;Binding;Biochemical;Biology;Breast Cancer Model;cancer cell;cancer immunotherapy;Cancer Model;cancer therapy;cancer type;Cells;Chemicals;Chromosomal Instability;Cyclic GMP;Dendritic Cells;Detection;Development;DNA Binding;DNA Damage;drug development;ds-DNA;Enzymes;Exhibits;extracellular;fighting;Functional disorder;Genetic;Goals;Hydrolase;Hydrolysis;Immune;immune activation;immune checkpoint blockers;Immune response;Immunologics;Immunotherapeutic agent;improved;In Vitro;in vivo;Infiltration;inhibitor;innate immune checkpoint;Innate Immune System;Interferon Type I;Ionizing radiation;Kinetics;Knock-out;Lead;Malignant Neoplasms;Membrane;Modeling;Molecular;mouse genetics;mouse model;Mouse Strains;Mus;mutant;Mutation;Natural Immunity;nucleoside triphosphate;overexpression;pancreatic cancer model;paracrine;Pathway interactions;Patients;pharmacologic;Physiological;Physiology;Play;Point Mutation;prevent;Production;receptor;response;Role;Second Messenger Systems;side effect;Signal Pathway;Signal Transduction;Site;small molecule;standard of care;Structure-Activity Relationship;Substrate Specificity;synergism;Testing;Tissues;tool;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor Promotion

PROJECT_TITLE: Investigating the roles of extracellular cGAMP and harnessing it for cancer treatment

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: PORTLAND

ORG_DEPT: PEDIATRICS

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE Necrotizing enterocolitis (NEC) is a deadly disease that affects premature infants with a weakened intestinal barrier, exaggerated immune response, and an abnormal intestinal microbiota. We are examining a factor called IMP1 that is important in intestinal development, including impacting intestinal barrier function, the immune system, and extracellular vesicle (EV)-mediated communication. Results from our study will identify new therapeutic targets for NEC through a deeper understanding of IMP1 and its role in intestinal barrier maintenance and function.

PI_NAMEs: ANDRES, SARAH  (contact)

PROJECT_TERMS: Adherent Culture;Affect;Autophagocytosis;Bacteria;Binding;Binding Proteins;Bioethics;Biology;career;career development;Cell Communication;Cell Maintenance;Cells;chemokine;Communication;cytokine;Development;diagnostic strategy;Disease;dysbiosis;Epithelium;Etiology;Exposure to;extracellular vesicles;Foundations;Functional disorder;Funding;Gastroenterology;gastrointestinal;Genetic;Goals;Grant;gut microbiota;Human;Hypersensitivity;IGFBP2 gene;Immune;immune activation;immune cell infiltrate;immune function;Immune response;Immune system;Immunology;Immunoprecipitation;improved;Infant;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Ingestion;inhibition of autophagy;Integrins;intercellular communication;intestinal barrier;intestinal epithelium;Intestines;K-Series Research Career Programs;Knock-out;Knowledge;Laboratories;Lamina Propria;Leadership;Leaky Gut;Life;Lipids;Macrophage;Macrophage Activation;Maintenance;Manuscripts;Maps;Mediating;Mentors;Messenger RNA;MicroRNAs;migration;Modeling;Molecular;mortality risk;mouse model;Mucous Membrane;Mus;nano-string;Necrotizing Enterocolitis;Neonatal;neonate;new therapeutic target;novel;novel diagnostics;Nutrient;overexpression;Pathogenesis;Pathway interactions;Patients;Peptides;Physiological;Play;polarized cell;Population;Post-Transcriptional Regulation;postnatal;posttranscriptional;Pregnancy;premature;Premature Birth;Premature Infant;Prevention;Prevention strategy;Production;Proteins;Research;response;RNA;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Role;Scientist;skill acquisition;skills;Small Intestines;stem cell division;stem cells;System;Techniques;Testing;Transcript;treatment strategy;United States National Institutes of Health;Vesicle;Work;Writing

PROJECT_TITLE: The role of the RNA binding protein IMP1 in intercellular communication and necrotizing enterocolitis


NIH_SPENDING_CATS: Prevention

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

PHR: PROJECT NARRATIVE The Tropical Medicine Research Center (TMRC) Program comprises a set of institutes that conduct research on neglected tropical diseases for the development of prevention and therapeutic strategies. As the TMRC Program Coordinating Center (CC), RTI International will provide the administrative, communication, logistical, and operational resources to maximize the scientific productivity and public health impact of the TMRC research. These benefits will be realized by increasing coordination, collaboration, and information sharing among these diverse TMRCs and between the TMRCs and external stakeholders.

PI_NAMEs: NOLEN, TRACY L (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;Affect;Award;Awareness;biobank;Brazil;China;Client;Clinical;Clinical Data;Clinical Trials;cloud based;Collaborations;Collection;Communication;Communication Tools;Communities;Complex;Conflict of Interest;Country;Data;data exchange;data harmonization;data management;data sharing;data standards;design;Development;Disease;Disparate;Ecosystem;Epidemiology;experience;Fostering;Funding;Funding Opportunities;Geography;Ghana;Goals;Healthcare;Inbreeding;India;Informatics;Infrastructure;innovation;International;Internet;Knowledge;Link;meetings;Mentors;Monitor;National Institute of Allergy and Infectious Disease;neglect;neglected tropical diseases;next generation;novel;Participant;Persons;Peru;Philippines;Population;Poverty;Prevention;Prevention strategy;Procedures;Process;Productivity;programs;Public Health;Publications;Qualifying;Ramp;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Role;Sampling;Sanitation;Scientist;Specimen;Sri Lanka;System;Technical Expertise;Technology;technology validation;Thailand;Therapeutic;Time;tool;treatment strategy;Tropical Medicine;Tunisia;vector control;virtual;virtual repository;Visit;Water;web portal;Work;working group

PROJECT_TITLE: Tropical Medicine Research Centers: TMRC Coordinating Center


ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The nervous system depends on long projections called axons that connect nerve cells across the human body. This project will identify new factors that control the vulnerability of axons to self-destruction in response to stress or damage. Insights from this project will identify new avenues for protecting axon function and improving clinical outcome in disease.

PI_NAMEs: SUMMERS, DANIEL  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Alzheimer's Disease;Apoptosis;Attention;Autophagocytosis;Axon;axon injury;axonal degeneration;Axonal Transport;Axotomy;Cell Death;Cessation of life;Chemotherapy-induced peripheral neuropathy;Chronic;Clinical;Cytoskeleton;Cytosol;Data;Disease;Distal;Dynein ATPase;Enzymes;Event;Future;Gatekeeping;Genes;Genetic;Genetic Epistasis;Goals;Health;Homeostasis;Human;Human body;Hydrolase;Image;immune clearance;Immune system;improved;in vivo;insight;Investigation;Knockout Mice;MAP Kinase Gene;Mediating;Membrane;Modeling;Molecular;nerve damage;Nerve Degeneration;Nerve Fibers;Nervous System;Neurobiology;Neurodegenerative Disorders;neuron loss;neuronal cell body;Neurons;neuroprotection;novel;Onset of illness;Optic Nerve;Outcome;Parkinson Disease;Pathologic;Pathway interactions;Patients;Peripheral Nervous System;Peripheral Nervous System Diseases;Pharmacology;Predisposition;programs;protein aggregation;proteostasis;Recycling;Research;response;Role;Sensory;Severities;Severity of illness;Signal Transduction;Stress;Therapeutic;trafficking;Trauma;Traumatic Brain Injury;Work

PROJECT_TITLE: Identifying mechanisms that regulate local axon vulnerability to pathological degeneration

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]