ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative These studies seek to identify the role of erythropoietin (EPO) in macrophage training during alloimmune response taking advantage of conditional KO mice. The experiments will employ: i) mouse models of heart transplantation with prolonged cold ischemia storage, ii) life-sustaining kidney transplant models (showing pathological features similar to those found in human transplant recipients), and iii) previously stored samples from kidney transplant recipients treated with EPO. The proposed mechanistic studies will improve our understanding of alloimmunity and will identify therapeutic targets to improve outcomes of transplant recipients.

PI_NAMEs: CRAVEDI, PAOLO  (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;allograft rejection;Anemia;Anti-Inflammatory Agents;ATAC-seq;Autoantibodies;Autoimmune;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;B-Lymphocytes;biobank;Biological Assay;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Clinic;cytokine;Data;Deacetylase;disease model;Down-Regulation;effector T cell;end-stage organ failure;Epigenetic Process;EPO gene;EPOR gene;Erythropoietin;Erythropoietin Receptor;experimental study;Exposure to;FDA approved;Functional disorder;Funding;Genetic Transcription;Graft Rejection;Graft Survival;Grant;Heart Transplantation;Helper-Inducer T-Lymphocyte;Heterogeneity;Homologous Transplantation;Hormones;Human;Hypoxia;Immune;Immunity;immunoregulation;Immunosuppressive Agents;improved;improved outcome;In Vitro;in vivo;Inbred BALB C Mice;Individual;Infiltration;Inflammatory;inhibitor;Injections;insight;Ischemia;ischemic injury;isoimmunity;kidney cell;Kidney Diseases;Kidney Transplantation;knock-down;Knockout Mice;Life;lupus prone mice;Macrophage;Macrophage Activation;Mediating;Metabolic;Modeling;Modification;Molecular;Monitor;monocyte;mouse model;Mus;Myeloid Cells;new therapeutic target;organ transplant recipient;pathogen;Pathologic;Pathway interactions;Pattern;Peripheral Blood Mononuclear Cell;Phagocytosis;pharmacologic;Phosphoric Monoester Hydrolases;Physiological;Play;Predisposition;prevent;Production;programs;Regulatory T-Lymphocyte;Research Project Grants;response;Role;Sampling;Severities;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SIRT1 gene;Stimulus;System;T-Lymphocyte;Testing;therapeutic target;Time;TLR9 gene;Training;transcriptome sequencing;transcriptomics;Transforming Growth Factor beta;Translating;transplant model;Transplant Recipients;Transplantation;transplantation medicine

PROJECT_TITLE: Erythropoietin and trained immunity intransplantation

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Immunotherapy;Pediatric;Prevention;Transplantation

ORG_CITY: SIOUX FALLS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SANFORD RESEARCH/USD

ORG_STATE: SD

PHR: Project Narrative Defective immune tolerance promotes autoreactive T effector lymphocytes, which destroy the insulin-producing β cells in the pancreatic islets, causing overt hyperglycemia. The goal of our application is to design, develop, and rigorously test the engineered regulatory T cells carrying Chimeric Antigen Receptor (CAR) recognizing unique β cells surface antigen, NDTPase3, for their ability to suppress diabetic autoimmunity in both in vitro and in vivo settings. We expect our CAR Tregs to accumulate within pancreatic islets and efficiently protect them from autoimmune assault, forming the foundation for future clinical trials.

PI_NAMEs: ABDULREDA, MIDHAT H;MATHEWS, CLAYTON E;SAVINOV, ALEXEI YURIEVITCH (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Adoptive Transfer;Affinity;Alleles;anterior chamber;Antibodies;Antibody Binding Sites;antigen binding;Antigens;assault;Autoimmune;autoimmune pathogenesis;Autoimmunity;Autologous;autoreactivity;Beta Cell;Binding;C-Peptide;CD4 Positive T Lymphocytes;CD8B1 gene;Cell Count;Cell Line;Cell Physiology;Cell Separation;Cell Surface Proteins;Cell Therapy;Cells;chimeric antigen receptor;Clinical Trials;Clone Cells;Coculture Techniques;Computer Models;cytokine;design;Development;diabetes control;diabetic;diabetogenic;draining lymph node;engineered beta cell;Engineering;Engraftment;Enzyme-Linked Immunosorbent Assay;exhaustion;eye chamber;Foundations;Frequencies;Future;Goals;Hand;HLA-DQ8 antigen;Home;Homing;Horns;Human;Human Activities;Human Engineering;human model;Hyperglycemia;Immune;immune self tolerance;Immune Tolerance;Immunoglobulin Fragments;Impairment;Implant;improved;in silico;In Situ;In Vitro;in vivo;in vivo evaluation;in vivo Model;Individual;innovation;Insulin;insulin secretion;Insulin-Dependent Diabetes Mellitus;Interdisciplinary Study;intravital imaging;islet;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Kinetics;Lymphocyte;Measures;migration;Motility;Mus;mutant;novel;Pancreas;Pathogenicity;Patients;Persons;Phase I Clinical Trials;Predisposition;preservation;prevent;Production;Proliferating;Receptor Signaling;Regulatory T-Lymphocyte;Research;restraint;Self Tolerance;Silicon Dioxide;Slice;Specificity;Structure of beta Cell of islet;success;Surface;Surface Antigens;Surface Plasmon Resonance;T cell therapy;T-Lymphocyte;Technology;Testing;Therapeutic;Transgenic Mice;Translating;transplant model;Transplantation;Variant

PROJECT_TITLE: Engineering Human T Regulatory Cells with Chimeric Antigen Receptor Targeting NTPDase3 on the Surface of β cells for Type 1 Diabetes Control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-D(02)M]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Intracellular pathogens represent a serious threat to human health, and to devise strategies to combat infections by these microbes a more detailed understanding of how they modulate host cell function is needed. This project is focused on identifying molecular mechanisms that allow the intracellular pathogen Coxiella burnetii to manipulate the function of host proteins, which include innate immune sensors that activate pathways of host defense against intracellular pathogens.

PI_NAMEs: ROY, CRAIG R. (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute Disease;Address;Animals;Biochemical;Biogenesis;bioluminescence imaging;Cell Physiology;Cells;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;combat;Complex;Coxiella;Coxiella burnetii;cytokine;Cytosol;Defect;Detection;Disease;Endocarditis;Exhibits;Genes;Genetic;Genetic Screening;Genome;genome editing;Goals;Health;Homologous Gene;Host Defense;Host Defense Mechanism;Human;human disease;human pathogen;imaging approach;Immune;Immune response;Immunity;Individual;Infection;Innate Immune Response;Interferon Type I;Knowledge;Legionella;Libraries;Life Style;Link;loss of function;Lysosomes;Mammalian Cell;Mammals;Maps;Measures;Microbe;Molecular;mutant;Names;novel;Organelles;Organism;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptide Hydrolases;Phenotype;Phylogenetic Analysis;prevent;Production;Property;Protein Analysis;Proteins;Proteobacteria;Q Fever;response;RNA;Role;screening;sensor;Signal Pathway;Signal Transduction;Synteny;System;Techniques;tool;trait;transposon sequencing;Ubiquitin;Vacuole;Virulence

PROJECT_TITLE: The Role of Coxiella Effector Proteins in Infection and Disease

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Neurosciences;Nutrition

ORG_CITY: DALLAS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: The proposed studies aim to investigate the acute and chronic effects of GLP-1 on neural circuits and the overlap with GLP-1R agonists to improve metabolism. This research has important clinical implications as GLP-1 receptor agonists are exceedingly common therapeutics in diabetes treatment and chronic weight management.

PI_NAMEs: WILLIAMS, KEVIN W (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acute;Affect;Agonist;Anti-diabetic Drugs;Blood Glucose;Body Weight;Brain;Brain region;Calcium;Cell Nucleus;Cells;Chronic;Clinical;Data;design;Diabetes Mellitus;Electrophysiology (science);Exercise;experimental study;Food;gamma-Aminobutyric Acid;GCG gene;Genetic;genetic approach;GLP-I receptor;glucagon-like peptide 1;Glucose;glucose production;Hand;Hypothalamic structure;Image;improved;in vivo;in vivo calcium imaging;insight;Intake;Interneurons;leptin receptor;Link;Medial Dorsal Nucleus;Mediating;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Modeling;Monitor;mouse model;neural;neural circuit;neuronal circuitry;Neurons;neuropeptide Y;Neuropeptide Y Receptor;neurotransmission;novel;Obesity;optogenetics;patch clamp;Peptides;Pharmaceutical Preparations;Physiological;Physiology;Property;reduced food intake;Regulation;Research;response;Role;Satiation;Signal Transduction;Structure of nucleus infundibularis hypothalami;Synapses;System;Testing;Therapeutic;Weight maintenance regimen;Work

PROJECT_TITLE: Acute and chronic effects of GLP-1R agonism on NPY/AgRP neuronal activity

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Tuberculosis (TB), a worldwide infectious disease caused by Mycobacterium tuberculosis (M.tb), has over the last few decades, become resistant to one or more anti-TB drugs, which is a big challenge for TB eradication program. We discovered that M.tb infection enhances the expression and activity of MDR1 in macrophages, which allows the macrophage to transport TB drugs and endogenous anti-microbial out of the cells, thereby promoting M.tb growth. We will investigate whether inhibition of MDR1 expression in mice shortens the TB treatment period and enhance the M.tb killing.

PI_NAMEs: RAJARAM, MURUGESAN  (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: 3' Untranslated Regions;ABCB1 gene;Ablation;Affect;Alleles;Animals;antimicrobial;Autophagocytosis;Bacteria;Basic Science;Biochemical;Biochemistry;Cause of Death;Cells;Cellular biology;Cessation of life;Chemicals;Combined Antibiotics;Communicable Diseases;Computational Biology;cost;cytokine;Data;Development;Dose;Drug Efflux;drug quality;drug resistance development;Drug resistance in tuberculosis;Effectiveness;efflux pump;Ethambutol;experimental study;Exposure to;Extreme drug resistant tuberculosis;Foundations;Free Radicals;Genetic Techniques;Genetic Transcription;Goals;Growth;Heat shock factor;heat shock transcription factor;heat-shock factor 1;Human;Immune;Immune response;Immune system;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Incidence;Infection;Infectious Agent;Inflammatory;inhibitor;Innate Immune Response;innovation;Integration Host Factors;isoniazid;Journals;Laboratories;Length;Life Cycle Stages;Link;Lung;Lung Diseases;Lysosomes;Machine Learning;Macrophage;Macrophage Activation;Mediating;medication compliance;Methods;Mission;monocyte;mortality;mouse model;Multidrug-Resistant Tuberculosis;Mus;Mycobacterium tuberculosis;Nature;Nitrogen;novel;novel drug combination;novel therapeutic intervention;novel therapeutics;Oxygen;Pathogenesis;Pathway interactions;Patients;Phagosomes;Pharmaceutical Preparations;pharmacologic;Play;Population;Predisposition;pressure;prevent;Production;programs;Property;Proteins;Public Health;public health relevance;Pulmonary Tuberculosis;Pump;Pyrazinamide;recruit;Regimen;Research;Resistance;resistant strain;response;Rifampin;Role;Signal Transduction;Single Nucleotide Polymorphism;Sterilization;substance use;System;Tariquidar;Therapeutic;Time;treatment duration;Treatment Protocols;tripterine;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Up-Regulation;Work

PROJECT_TITLE: Mechanism of macrophage efflux system in Mycobacterium tuberculosis pathogenesis

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Diabetes;Neurosciences

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: How our brain senses and responds to changes in blood glucose levels is incompletely understood. We have identified Adgrl1 as a glucoreceptor in the brain, which appears to be involved in counteracting hypoglycemia (dangerously low blood glucose levels). Through this study, we will establish the contribution of Adgrl1 to glucose sensing in the brain and its function in glucose homeostasis including counteracting hypoglycemia. Adgrl1 may emerge as a new target for preventing hypoglycemia or associated autonomic failure in diabetes.

PI_NAMEs: CHHABRA, KAVALJIT H (contact)

PROJECT_TERMS: Adhesions;Adrenal Glands;Biological;Blood Glucose;blood glucose regulation;Brain;Cell Nucleus;Chromaffin Cells;clinically relevant;Closure by clamp;Continuous Glucose Monitor;Coupled;Dangerousness;Data;defined contribution;Deterioration;Diabetes Mellitus;Diabetic mouse;Electrophysiology (science);Equilibrium;Failure;Fiber;G-Protein-Coupled Receptors;Glucose;glucose monitor;glucose receptor;Glutamates;Homeostasis;Human;Hyperinsulinism;Hypoglycemia;Hypothalamic structure;Iatrogenesis;Impairment;improved;in vivo;Insulin;Insulin-Dependent Diabetes Mellitus;Knockout Mice;Measurement;Measures;Mediating;Messenger RNA;Methods;Modeling;Monitor;mouse model;Mus;Nerve;Neurons;novel;Pharmaceutical Preparations;Phenotype;Photometry;prevent;Procedures;Protocols documentation;real time monitoring;Recurrence;response;restoration;Risk;Role;Streptozocin;Synapses;Synaptic Transmission;Testing;Time;transmission process;vector

PROJECT_TITLE: Role of Hypothalamic Adgrl1 in Counteracting Hypoglycemia


NIH_SPENDING_CATS: Asthma;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE WHO estimated that 20% of the world’s population suffer from respiratory allergies and derived diseases such as allergic rhinitis and asthma. However, there is still no clear answer to the question: “why do only some people develop allergy?”, underscoring the need to revisit our understanding of immune mechanisms of allergy. Using novel genomics unbiased tools, we discovered a new type of T cells, we called THIFNR cells, that may play an important role in preventing pathogenic inflammation in allergy and asthma. This grant aims to advance our understanding of the role of this novel subset in controlling allergic immune responses. Our work will provide novel mechanistic insights that may lead to the development of better therapeutic options for patients with allergic diseases.

PI_NAMEs: SEUMOIS, GREGORY  (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: 2019-nCoV;Address;airway inflammation;Allergens;Allergic;Allergic Disease;allergic response;Allergic rhinitis;Asthma;asthmatic;Automobile Driving;Bioinformatics;Blood specimen;CD4 Positive T Lymphocytes;Cell Death;Cells;Circulation;Clinic;Coculture Techniques;Code;cohort;COVID-19 patient;cytokine;Development;Disease;dust mite allergy;experimental study;Exploratory/Developmental Grant;Exposure to;Extrinsic asthma;flu;Follow-Up Studies;Frequencies;fungus;Future;genetic signature;Genomics;Grant;Health;Heterogeneity;House Dust Mite Allergens;Human;Hypersensitivity;Immune;Immune response;Immunology;In Vitro;in vivo;Individual;Inflammation;Influenza;insight;Interferon-beta;Interferons;Ligands;Mediating;memory CD4 T lymphocyte;novel;Pathogenicity;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;prevent;Process;Production;Proliferating;Property;Proteins;Pyroglyphidae;receptor;Research;respiratory;respiratory virus;response;Role;Sampling;Science;Structure of parenchyma of lung;Surface;T cell receptor repertoire sequencing;T-Cell Activation;T-cell diversity;T-cell receptor repertoire;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Th1 Cells;Th2 Cells;Therapeutic;Tissue Sample;TNF-related apoptosis-inducing ligand;TNFSF10 gene;tool;transcriptome;Translating;Viral;Visit;Work

PROJECT_TITLE: A novel CD4+ T cell subset associated with allergy protection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDB-K(57)]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Narrative The Nonhuman Primate Reagent Resource (NHPRR) develops, manufactures, and distributes research reagents for more than 21 years. These species-matched immunologic tools help investigators develop and utilize preclinical monkey models of human diseases–from infectious diseases to organ transplantation. This application describes the scientific and operational goals for our resource program's next cycle, using new reagent development methodologies and expanded community outreach plans to maximize the NHPRR's impact in nonhuman primate research.

PI_NAMEs: ENGELMAN, KATHLEEN ;MAGNANI, DIOGO  (contact)

PROJECT_TERMS: Acceleration;Animal Model;Animals;Antibodies;antibody detection;Biological;Biological Markers;Biological Response Modifier Therapy;Biological Testing;Cells;Communicable Diseases;Communities;Community Outreach;Data;Databases;design;Development;Development Plans;Discipline;Disease;disease model;Electronics;Engineering;Five-Year Plans;Formulation;Future;Goals;Human;human disease;human model;Immune;Immunologics;Immunomodulators;immunoregulation;improved;in vivo;in-vitro diagnostics;Infrastructure;large scale production;manufacture;Methodology;Modeling;Monkeys;Monoclonal Antibodies;Names;Natural Killer Cells;next generation;nonhuman primate;novel;novel therapeutics;operation;Organ Transplantation;outreach;Pathogenesis;Peptide Hydrolases;Population;pre-clinical;Production;programs;Quality Control;Reaction;Reagent;Recombinant Antibody;Recombinants;Records;Research;Research Personnel;Resources;response;Role;Scientific Advances and Accomplishments;Services;Source;Technology;tool;Translational Research;Vaccines;web site

PROJECT_TITLE: Nonhuman Primate Reagent Resource


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HADLEY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Our work over the past two decades has focused on understanding caspase regulation at a structural level and has resulted in development of the most selective and potent caspase-6 inhibitor to date. We have recently found that NMR is essential for our understanding of this system. The goal of this supplement is to purchase a helium recovery system which will enable robust and reliable functioning of our 800 MHz NMR spectrometer while dramatically improving the environmental impact of cooling the high-field magnet.

PI_NAMEs: HARDY, JEANNE ANN (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Active Sites;Allosteric Site;Apoptotic;Award;Binding;Biological Sciences;Cancerous;CASP6 gene;Caspase;Cell Death;Cells;conformational conversion;Development;Disease;Drug Targeting;Environmental Impact;Equilibrium;experimental study;Family;Funding;Goals;Helium;improved;inhibitor;interest;Liquid substance;manufacture;Marketing;Massachusetts;Molecular Conformation;Myocardial Infarction;Nerve Degeneration;NMR Spectroscopy;Phosphorylation;Play;prevent;quantum technologies;Recovery;Regulation;Reporting;Role;Stroke;System;Work;Zinc

PROJECT_TITLE: Supplement for Discovering and Exploiting Caspase Regulatory, Allosteric and Exosites


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The supplement project aims to develop a PrEP intervention for people engaging in sex work in Alabama. The project is grounded in syndemics theory and implementation science frameworks to directly address the needs of an underserved population through community-academic partnership.

PI_NAMEs: HEFFRON, RENEE A. (contact)

PROGRAM_OFFICER_NAME: SCHOONMAKER, ANNALISE ROSA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Alabama;behavioral outcome;Caring;Characteristics;Client;Clinical;Clinical Trials;Color;Communities;community academic partnership;community partners;Consolidated Framework for Implementation Research;COVID-19 pandemic;Data;design;Drug usage;Drug user;effectiveness evaluation;Epidemic;Epidemiologic Methods;ethnic identity;evidence base;Evidence based intervention;experience;Face;Food;Gender Identity;Geography;Harm Reduction;Health;Health equity research;Healthcare;Hepatitis C Prevalence;Hepatitis C virus;Heterogeneity;HIV;HIV diagnosis;HIV Infections;HIV/STD;Housing;implementation framework;Incidence;Individual;informant;Injecting drug user;Intervention;Interview;Measures;member;method development;Methods;Neighborhoods;Not Hispanic or Latino;novel;Online Systems;Outcome;outreach;Persons;Pharmaceutical Preparations;Population;pre-exposure prophylaxis;Prevalence;Prevention;preventive intervention;programs;Provider;racial identity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Resources;response;Risk;Risk Reduction;role model;Services;sex;social;social stigma;spatial epidemiology;Structural Racism;substance use;Surveys;syndemic;Syphilis;systematic review;Target Populations;Testing;testing access;theories;therapy development;timeline;tool;trend;Underserved Population;United States;uptake;Visit;Vulnerable Populations;Work

PROJECT_TITLE: A Harm Reduction Approach to Addressing the HIV, STIs, and Substance Use Syndemic Among People Engaging in Sex Work in Alabama


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Data Science;Genetics;Machine Learning and Artificial Intelligence

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE To understand disease mechanisms and develop effective treatments, we need to untangle the relationship between genetics and phenotypes of all organisms (such as human, mouse, zebrafish, and fruitfly). Sophisticated comparative information systems are needed to collect, search, and compare the diverse and often mutually incompatible data being generated. The Monarch Initiative has amassed the largest open collection of multi-species genotype-phenotype data in the world; here we propose to extend Monarch’s technology, data resources, and tools to use organismal data to advance precision medicine.

PI_NAMEs: HAENDEL, MELISSA A (contact);MUNGALL, CHRISTOPHER J;ROBINSON, PETER NICHOLAS

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Algorithms;Aloral;Animal Disease Models;Animal Model;Basic Science;bioinformatics tool;Biological;Body System;Clinical;clinical decision support;Collection;Communities;comparative;computable phenotypes;Computer software;computerized tools;Data;data access;data dissemination;data harmonization;data resource;Data Sources;deep learning;Diagnosis;Diagnostic;diagnostic algorithm;Disease;disease diagnosis;disease diagnostic;disease model;Drosophila genus;effective therapy;Ensure;Evaluation;experience;Feedback;Foundations;gene discovery;gene function;Genes;Genetic;Genetic Variation;Genotype;Goals;Graph;Human;improved;Individual;Information Systems;insight;Intuition;knowledge graph;Libraries;Link;Machine Learning;machine learning method;Manuals;Methods;model organism;Modeling;Monitor;multimodal data;Mus;National Health Services;novel;Ontology;operation;Organism;outreach;Pathway interactions;Patients;Performance;Phase;Phenotype;phenotypic data;precision medicine;Process;Quality Control;Rare Diseases;Reporting;Research;Research Personnel;Resources;Services;Structure;success;Techniques;Technology;Testing;tool;Training;Translational Research;treatment optimization;Unified Medical Language System;Variant;Visual;Visualization;web portal;web site;Work;Zebrafish

PROJECT_TITLE: The Monarch Initiative: Linking Diseases to Model Organism Resources

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-A(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: STANFORD

ORG_DEPT: SURGERY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Dilated cardiomyopathy (DCM), a complex cardiac disease is a leading cause of heart failure. The emergence of induced pluripotent stem cell (iPSC) technology offers an experimental human-based model to predict and model individual disease manifestations. The goal of this project is to study the underlying mechanisms of DCM by investigating the intricate crosstalk between cardiomyocytes and endothelial cells using bioengineering tools and next generation sequencing. Results from this work could potentially lead to new strategies that could lower morbidity and mortality, but also improve the management of DCM patients.

PI_NAMEs: SAYED, NAZISH  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;ATAC-seq;Attention;Biomedical Engineering;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiomyopathies;Cardiovascular Physiology;Cell Communication;Cell Line;cell type;Cells;Chromatin;Chromosome Mapping;Coculture Techniques;Collaborations;Communication;Complex;Computational Biology;CRISPR/Cas technology;Data;Dilated Cardiomyopathy;Disease;Endothelial Cells;endothelial dysfunction;env Gene Products;Environment;experimental study;familial dilated cardiomyopathy;Family;Functional disorder;Gene Deletion;Gene Expression;gene regulatory network;Genes;genome editing;Genomic DNA;Genotype;Goals;Heart;Heart Diseases;Heart failure;heart function;Heart Transplantation;Human;human induced pluripotent stem cells;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;induced pluripotent stem cell technology;insight;interdisciplinary approach;Kinetics;knock-down;Knowledge;lamin C;Lamin Type A;Ligands;loss of function;Lovastatin;Machine Learning;mechanical properties;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mutation;next generation sequencing;novel;Nuclear Envelope;Oligonucleotides;Organ;paracrine;Paracrine Communication;Pathogenesis;Pathogenicity;Patients;pharmacologic;Phenotype;Positioning Attribute;promoter;receptor;Research Proposals;Signal Transduction;single cell ATAC-seq;single cell technology;single-cell RNA sequencing;Site;sound;stem cell biology;Technology;Tissue Engineering;tool;transcription factor;translational medicine;Translational Research;Variant;Wing;Work;Zebrafish

PROJECT_TITLE: Deciphering the Endothelial Cell-Cardiomyocyte Crosstalk in LMNA Cardiomyopathy

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: DULLES

ORG_STATE: VA

PI_NAMEs: BUTTE, ATUL  (contact)

PROJECT_TERMS: analytical tool;biodefense;Bioinformatics;Clinical Data;Contracts;data access;Data Collection;data integration;Data Storage and Retrieval;Databases;Development;Environment;Funding;Immunology;Information Technology;Infrastructure;interoperability;Methods;novel;Production;quality assurance;Research;Services;tool

PROJECT_TITLE: THE IMMUNOLOGY DATABASE AND ANALYSIS PORTAL (IMMPORT)


NIH_SPENDING_CATS: Data Science;Emerging Infectious Diseases;Infectious Diseases

PROJECT_TERMS: Certification;Clinical Research;COVID-19;data access;data integration;data repository;data resource;Data Set;data sharing;Databases;Documentation;FAIR principles;Funding;Immunology;Infrastructure;Process;programs;Readiness;research study;sharing platform;trustworthiness;United States National Institutes of Health


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The way an individual responds to cues associated with rewards may be a key determinant in vulnerability to addiction and relapse. We will utilize an animal model to identify critical components of the neural circuitry that that contribute to individual differences in cue-reward learning and relapse propensity. The findings from these studies will enhance our understanding of the pathophysiology of substance abuse and could lead to novel targets for the treatment of addiction and related disorders.

PI_NAMEs: FLAGEL, SHELLY BETH (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Abstinence;addiction;addiction liability;Affect;Animal Model;Attenuated;Behavior;Behavior Control;cocaine self-administration;Corpus striatum structure;Cues;designer receptors exclusively activated by designer drugs;Disease;Dopamine;Drug Addiction;drug seeking behavior;Drug user;Engineering;Environment;Equilibrium;experience;experimental study;Exposure to;Extinction;Food;Functional disorder;genetic approach;Goals;hypocretin;Hypothalamic structure;in vivo;incentive salience;Incentives;Individual;Individual Differences;individual variation;interest;Lateral;Learning;Lesion;maladaptive behavior;Mediating;Microdialysis;Molecular Genetics;motivated behavior;Motivation;motivational processes;neural;neural circuit;Neurobiology;neurochemistry;Neurons;novel;Nucleus Accumbens;Output;Pathway interactions;Pharmaceutical Preparations;Play;Predictive Value;Predisposition;Process;Property;psychologic;Psychopathology;Rattus;receptor;Relapse;Resources;response;Rewards;Role;selective expression;Signal Transduction;Stimulus;Structure of paraventricular nucleus of thalamus;Substance abuse problem;Testing;Thalamic structure;Variant;vector;Ventral Tegmental Area;Viral Vector;Work

PROJECT_TITLE: Probing the role of a hypothalamic-thalamic-striatal circuit in cue-driven behaviors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: DURHAM

ORG_NAME: INNOVATION RESEARCH AND TRAINING, INC.

PHR: Project Narrative Community college students make up almost half of the college population, but very little research has focused specifically on this underserved group, and no research has examined their sexual health across emerging adulthood—a critical period during which the achievement of vocational, relational, and identity development milestones are intertwined with sexual decision making. We propose a project to 1) conduct the first longitudinal investigation of media use, sexual health, and quality of life of community college students across emerging adulthood—helping to expand theory and identify the most pressing directions for future programming— and 2) conduct a mixed methods study to better understand how community colleges can create more inclusive and affirming environments to support the sexual health of sexual and gender minority youth. Together, with an advisory panel of community college stakeholders, we will disseminate findings to research communities and decision makers at community colleges across the U.S., to help them better address the needs of the rising generation of emerging adults attending community college.

PI_NAMEs: SCULL, TRACY MARIE (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Achievement;Address;Administrator;Adult;Age;Attention;Attitude;Behavior;Behavioral;Belief;college;Communities;community advisory board;community college;Complex;critical developmental period;critical period;Data;Data Collection;data integration;Decision Making;design;Development;digital;Discrimination;diverse data;Education;effectiveness evaluation;emerging adult;emerging adulthood;Employment;Ensure;Environment;Ethnic Origin;experience;follow-up;Future;Gender;Gender Identity;gender minority youth;Generations;Growth;Health;Health Promotion;Health Resources;high risk sexual behavior;Housing;Individual Differences;innovation;Institution;Intercept;Interview;Investigation;Investments;literacy;Longitudinal cohort;Mainstreaming;Measures;media use;member;Methods;Modeling;Outcome;Participant;Pattern;peer;Persons;Policies;Population;Populations at Risk;Pornography;Procedures;Process;programs;Protocols documentation;psychologic;Quality of life;Questionnaires;Race;recruit;Reporting;Reproductive Health;Research;research data dissemination;Research Personnel;Resources;Risk;Risk Taking;Role;Sampling;sex;Sex Orientation;Sexual Development;Sexual Health;sexual identity;sexual minority youth;Sexual Partners;social structure;Sociology;Source;Structure;Students;success;Testing;theories;Time;transition to adulthood;trend;trustworthiness;Underserved Population;underserved students;unintended pregnancy;university student;Unsafe Sex;Vocation;Voice

PROJECT_TITLE: Examining reproductive and sexual health during the transition to adulthood

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: CA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Pancreatic Cancer;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE Cancer cells employ lysosome-mediated nutrient acquisition strategies to survive limited nutrient availability in the harsh tumor microenvironment. Here, we will develop innovative technologies to profile the lysosomal molecular content at cell-type-specific resolution in tumors in vivo. Our work will enable the discovery of how cells adapt to fluctuations in nutrient availability and uncover cancer-specific metabolic vulnerabilities that can be exploited to treat human malignancies.

PI_NAMEs: ABU-REMAILEH, MONTHER  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: Autophagocytosis;Biochemical Reaction;Biological Models;biological systems;cancer cell;Carbon;Cell membrane;cell type;Cells;design;Diffusion;Environment;Eukaryota;Eukaryotic Cell;Evolution;extracellular;flexibility;Gene Expression Regulation;Genetic;Glucose;Growth;Human;in vivo;innovation;innovative technologies;Lac Operon;Lactose;Lipids;Lower Organism;Lysosomes;macromolecule;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metabolic;metabolic abnormality assessment;Metabolism;Molecular;mouse model;new therapeutic target;novel strategies;Nutrient;Nutrient availability;Organelles;Oxygen;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Prokaryotic Cells;Proteins;Recycling;Resolution;response;Role;Source;stressor;Stromal Cells;System;tool;tumor;tumor metabolism;tumor microenvironment;tumorigenesis;Vascularization;Work

PROJECT_TITLE: Innovations and mechanisms in tumor subcellular metabolism


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The proposed research will establish a revolutionary and widely applicable experimental strategy with the scale and throughput to understand how diverse gene mutations found in cancer cooperate to influence aggressive behaviors of cancer cells. The approach will rapidly advance our understanding of the genetic basis of prostate cancer and accelerate the generation of prostate cancer models that mirror the genetic complexity of the disease.

PI_NAMEs: LEE, JOHN KYUNG (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Address;Aggressive behavior;Bar Codes;Benign;Biological;Biological Assay;Cancer Biology;cancer cell;cancer genome;cancer genomics;cancer initiation;cancer subtypes;clinically relevant;Complex;Development;Disease;Epithelial Cells;Event;Evolution;flexibility;gain of function;gene interaction;Gene Mutation;gene network;Generations;Genetic;Genetic Heterogeneity;Genomic approach;genomic data;Genomics;Genotype;Goals;human disease;insight;Libraries;loss of function;Malignant neoplasm of prostate;Malignant Neoplasms;mouse model;Neurosecretory Systems;next generation;next generation sequencing;Phenotype;Prostate;prostate cancer model;Research;single cell sequencing;System;tool;transdifferentiation;tumor progression

PROJECT_TITLE: Uncovering diverse genotype-phenotype relationships in prostate cancer


NIH_SPENDING_CATS: Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Solid tumors are responsible for the majority of cancer deaths in the United States. Researchers have been unable to widely employ CAR T cells, an effective form of cancer immunotherapy, to solid tumors due to a lack of tumor specific antigen targets and the risk of toxicity when target antigens are shared with normal, vital tissues. This project will optimize innovative and completely novel receptors capable of logic-gated control of CAR T cells, greatly enhancing their safety and tumor specificity, opening the door to effective therapy of solid tumors.

PI_NAMEs: MAJZNER, ROBBIE G. (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Antigen Presentation;Antigen Targeting;Autoimmunity;B lymphoid malignancy;Cancer Etiology;cancer immunotherapy;Caring;Cell Therapy;Cessation of life;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Dangerousness;Disease;effective therapy;Fibrosis;Generations;Immunotherapeutic agent;innovation;Logic;Malignant Neoplasms;Mediating;Myeloproliferative disease;neoplastic cell;Normal tissue morphology;novel;Output;Patients;prevent;receptor;Refractory;Relapse;Research Personnel;response;Risk;Safety;Solid;Solid Neoplasm;Surface;System;T cell response;T-Lymphocyte;Technology;Tissues;Toxic effect;tumor;Tumor Antigens;tumor specificity;Tumor Tissue;United States

PROJECT_TITLE: Hijacking the T cell machinery for logic-gated CAR T cell control


NIH_SPENDING_CATS: Aging;Cancer;Nutrition

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative:  Although both cancer rates and metabolic deregulation increase with age, it is not well understood how age-dependent metabolic changes affect cancer initiation and progression. In addition, we have limited knowledge of how age-associated metabolic differences in the tumor microenvironment contribute to carcinogenesis and how these changes are affected by environmental factors such as diet and microbial metabolites. In this proposal, we plan to elucidate age- associated metabolic changes in tumors and their microenvironment using advanced single cell technologies, which may lead to discovering metabolic liabilities and improve existing therapies.

PI_NAMEs: MIHAYLOVA, MARIA M. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Affect;Age;age related;age related changes;Aging;Animal Model;Area;cancer initiation;carcinogenesis;Cells;combinatorial;Diet;dietary;Environmental Impact;Environmental Risk Factor;Event;Heterogeneity;Immune system;improved;juvenile animal;Knowledge;Malignant Neoplasms;Metabolic;Metabolism;metaplastic cell transformation;microbial;microbiome;Neoplasm Metastasis;neoplastic cell;Nutrient;Oncogenic;Risk Factors;Science;single cell technology;Time;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression

PROJECT_TITLE: Determining Age-Dependent Metabolic Changes in Tumors and Their Microenvironment


NIH_SPENDING_CATS: Cancer;Neurosciences;Prevention

ORG_CITY: Boston

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: Project Narrative The proposed work seeks to define and exploit the neuronal identity of solid tumors to prevent cancer metastasis, the leading cause of death in cancer patients. Recently, the presence of peripheral nerves in solid tumors and the upregulation of neuronal genes within tumor cells themselves were both reported be associated with poor outcome in cancer. We will use cell biology, engineering and clinically translatable approaches to understand how neoneurogenesis occurs in tumors, how the neural identity of tumors impacts the systemic regulation of metastasis and how we can leverage this information for non-invasive monitoring and treatment of metastatic disease.

PI_NAMEs: OUDIN, MADELEINE JULIE (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Biophysics;Brain;cancer cell;Cancer Patient;Cause of Death;cell motility;Cells;Cellular biology;Central Nervous System;Cessation of life;Chemicals;Clinical;clinical translation;Cues;Detection;Development;Diagnosis;Disease;Disseminated Malignant Neoplasm;Drug Targeting;Engineering;Epithelium;Extracellular Matrix;FDA approved;Genes;Goals;Immune;Invaded;Lead;Malignant Breast Neoplasm;Malignant Neoplasms;mimicry;Neoplasm Metastasis;neoplastic cell;Nerve;neural;Neurons;Neurosciences;non-invasive monitor;novel;Organ;Outcome;Paper;Pathway interactions;perineural;Peripheral Nerves;Phenotype;prevent;Prevention strategy;Primary Neoplasm;Publishing;Regulation;Reporting;Research;Review Literature;Role;Solid Neoplasm;Therapeutic;Time;tumor;tumor growth;tumor microenvironment;tumor progression;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Defining and Exploiting the Neuronal Identity of Cancers


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative: Almost all advanced cancers will eventually progress on treatment, but the emergence of resistance in cancer is poorly understood despite its clinical importance. The primary challenge is that serial tissue samples (pre- and post-resistance as well as in-between) must be obtained to understand the molecular mechanisms of resistance, but this is not feasible at scale given the logistical challenges as well as potential for procedure- related complications of invasive tissue sampling. We propose to utilize a novel integrated clinical-grade liquid biopsy platform to comprehensively profile DNA, RNA, and methylation alterations from blood samples in order to more fully understand the dynamic evolution of treatment resistance in cancer, and to develop potential biomarkers for early detection.

PI_NAMEs: ZHAO, SHUANG  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: advanced disease;Advanced Malignant Neoplasm;Blood specimen;Cause of Death;Clinical;Complication;DNA;dynamical evolution;early detection biomarkers;Laboratories;liquid biopsy;Malignant Neoplasms;Methylation;Molecular;molecular dynamics;Molecular Evolution;Monitor;novel;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;potential biomarker;Procedures;Radiation;refractory cancer;Research;Resistance;Resistance development;resistance mechanism;Risk;RNA;Sampling;Techniques;Testing;therapy resistant;Time;Tissue Sample;tumor;tumor progression;United States

PROJECT_TITLE: DYNAMIC MOLECULAR EVOLUTION OF TREATMENT RESISTANT CANCER


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE: Stroke is a number one cause of long-term disability in the United States, affecting approximately 6.6 million Americans, with a total projected cost of $2.2 trillion from 2005 to 2050. Following a stroke, more than two-thirds end up with a disability in the upper limb that lowers the ability to perform many daily activities, including self-care, vocations, and leisure, thus diminishing the quality of life. This project aims to evaluate a new technology in enhancing hand functional recovery following stroke, thereby improving independence and quality of life, with a cost-effective method.

PI_NAMEs: SEO, NA JIN  (contact)

PROGRAM_OFFICER_NAME: BONNER, JOSEPH FRANCIS

PROJECT_TERMS: Accelerometer;Action Research;Activities of Daily Living;Address;Affect;American;arm;Biomechanics;Brachial Paresis;Caregiver Burden;chronic stroke;Clinical;clinical practice;Communication;Control Groups;cost;cost effective;Data;Devices;dexterity;Digit structure;disability;Dose;Double-Blind Method;Electric Stimulation;Electroencephalography;Esthesia;Esthetics;Evaluation;Feedback;finger movement;Fingers;follow-up;Frequencies;functional independence;Future;grasp;Hand;hand dysfunction;Hand functions;hand rehabilitation;improved;innovation;Intervention;Leisures;Lifting;Literature;Location;Long term disability;longitudinal analysis;Lower Extremity;Manipulative Therapies;Manuals;Measures;Mechanoreceptors;Methods;Modality;Motion;Motor;Motor Activity;Motor Cortex;motor impairment;Movement;neural;Neurons;new technology;novel;novel marker;Outcome;Outcome Measure;Paresis;Participant;Patient Compliance;Patient-Focused Outcomes;Peripheral;Pilot Projects;post intervention;post stroke;programs;Quality of life;Randomized;randomized, controlled study;Randomized, Controlled Trials;Recovery of Function;Research;Research Design;Rest;Risk;secondary analysis;Self Care;Sensory;Skin;smart watch;Standardization;Stroke;stroke survivor;Testing;Therapeutic;Time;translational potential;Translations;Treatment Efficacy;treatment group;United States;Upper Extremity;vibration;Vocation;Wrist

PROJECT_TITLE: Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Lung cancer remains the leading cause of cancer-related deaths worldwide, with early detection being critical for improving prognosis. This supplemental project, in response to NOT-CA-24- 058, proposes to leverage the National Lung Screening Trial (NLST) dataset to improve early lung cancer diagnosis by characterizing the differential trajectory of benign and malignant nodules on serial CTs. By integrating advanced AI-based algorithms, harmonizing CT scans, and incorporating patient-specific characteristics, we aim to enhance precision in lung cancer risk stratification and aid early detection efforts, ultimately reducing lung cancer mortality.

PI_NAMEs: LANDMAN, BENNETT A.;MALDONADO, FABIEN  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Affect;Algorithms;Area;Behavior;Benign;Biological Markers;Body Composition;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer risk;Cessation of life;Characteristics;clinically relevant;cohort;Data;Data Set;density;Development;Distant;Early Diagnosis;Emerging Technologies;Ensure;Funding;Heterogeneity;Image;image registration;imaging biomarker;imaging study;improved;Individual;innovation;interest;longitudinal dataset;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Maps;Measurement;Measures;Modeling;Morphology;mortality;multimodal data;Natural History;Nodule;novel;Outcome;parent project;Parents;Participant;Patients;Pattern;Positioning Attribute;predictive modeling;Prognosis;prospective;Protocols documentation;quantitative imaging;radiologist;Radiology Specialty;radiomics;Randomized, Controlled Trials;reconstruction;recruit;Research;response;Risk Assessment;risk stratification;Scanning;screening;Screening for cancer;serial imaging;Shapes;Structure of parenchyma of lung;Surface;Techniques;technological innovation;technology development;Time;tool;tumor;Validation;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Novel Integrative Approach for the Early Detection of Lung Cancer using Repeated Measures


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Depression;Genetics;Human Genome;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE Depressive symptoms are prevalent in up to 40% individuals with Alzheimer’s disease (AD). People affected by AD and depression show altered transcriptome and epigenome, but the shared molecular changes underlying AD-depression comorbidity is not understood. This proposal aims to identify coding and non-coding regulatory variants associated with shared genetic risk for depression and AD in multiple cohorts.

PI_NAMEs: PATHAK, GITA A (contact)

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Advisory Committees;Affect;age acceleration;age related;Aging;aging clocks;Alleles;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;apolipoprotein E-4;Architecture;attributable risk;biobank;biological adaptation to stress;Biological Aging;Biological Markers;Brain;Brain imaging;brain tissue;brain volume;career;carrier status;Chronic;Code;cohort;comorbid depression;comorbidity;Data;Data Analyses;Dementia;depressive symptoms;Development;Diagnosis;Disease;disease phenotype;DRD2 gene;drug repurposing;Drug Targeting;Educational workshop;Electronic Health Record;epigenome;epigenome-wide association studies;epigenomic profiling;epigenomics;exome;Family history of;Genes;Genetic;genetic information;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;Genomics;Genotype;Gerontology;gray matter;Health;healthcare burden;Heritability;high throughput technology;Hippocampus;Impaired cognition;Individual;interest;Laboratories;large scale data;Measures;Mediating;member;Mental Depression;Mental Health;Mentors;Messenger RNA;Methylation;model design;Modeling;Molecular;multidisciplinary;multimodality;Neurodegenerative Disorders;neuropsychiatry;novel;Outcome;PARK2 gene;Participant;Pathogenesis;Persons;Phase;phenome;Phenotype;Population;Predisposition;Prefrontal Cortex;Process;programs;protein expression;protein function;Proteome;Proxy;psychiatric comorbidity;Psychiatry;psychogenetics;Psychopathology;Quantitative Trait Loci;Recording of previous events;Regulatory Pathway;Research;Research Personnel;resilience;Risk;Risk Factors;risk variant;Role;Signal Transduction;Site;SNP array;Stratification;Testing;therapeutic target;Training;training opportunity;trait;transcriptome;transcriptomic profiling;transcriptomics;United States;Untranslated RNA;Variant;Veterans;Writing

PROJECT_TITLE: Multi-modal intersection of depression and genetic liability to Alzheimers disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Data Science;Immunization;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PI_NAMEs: HOEN, ANNE GATEWOOD (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: analysis pipeline;Archives;Award;Bioinformatics;bioinformatics pipeline;Biometry;Biostatistical Methods;Biostatistics Core;central database;Clinical;cloud based;Code;Collaborations;Communities;Computer software;Consultations;Custom;Data;data access;Data Analyses;Data Analytics;Data Collection;Data Discovery;data dissemination;data exploration;data handling;data integration;data management;data repository;data resource;Data Set;data sharing;data sharing networks;Data Storage and Retrieval;database query;Databases;design;Ensure;experience;Future;Goals;high dimensionality;Human Resources;human subject;Immune;Immunity;Immunology;Individual;Infant;innovation;Laboratories;maternal vaccination;Mothers;multidimensional data;multidisciplinary;news;novel;Online Systems;Pattern;Phase;portability;Procedures;programs;Protocols documentation;Publications;Quality Control;repository;Reproducibility;Research;Research Personnel;Resources;Role;Secure;Security;Services;Site;Standardization;statistical and machine learning;Study Subject;synergism;Terminology;Time;tool;web site;Work

PROJECT_TITLE: Data Management and Biostatistics


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Unintentional Childhood Injury

PHR: Project Narrative Despite decades of research, advancements in vehicle technology, and various intervention and legislative efforts, stark racial and ethnic disparities in child occupant safety persist. This research will use a breadth-to- depth approach that integrates knowledge obtained from population-level analyses (breadth) and individual-level data collection (depth) to identify why and where racial and ethnic disparities arise in child occupant safety, with a goal of directly informing future interventions and policies. This work is the next critical step to bolster protective efforts for the most vulnerable children, and will ultimately reduce the burden of crashes experienced by children, their families, and society.

PI_NAMEs: SARTIN, EMMA  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Accident and Emergency department;Accidental Injury;Address;Air Bags;Award;behavior change;Big Data;Black race;career;Caregivers;Cessation of life;Characteristics;Child;Childhood;Childhood Injury;Clinical assessments;Code;Cohort Studies;Complex;Continuity of Patient Care;cost;Coupled;Critical Illness;Data;Data Collection;data management;Databases;Development;developmental psychology;Diagnostic;disability;Disparity;disparity elimination;disparity reduction;Economics;effective intervention;Electronics;Epidemiologic Methods;Epidemiology;Ethics;ethnic disparity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Family;Fatality rate;Frequencies;Funding;Future;Goals;Health;Health behavior;health disparity;Hispanic;Hospitals;improved;Individual;Injury;innovation;Intervention;Interview;Joints;Knowledge;knowledge integration;Mediation;Mental Health;Mentors;Methodology;Methods;Minority;Minority Groups;Mission;Modeling;Mothers;National Institute of Child Health and Human Development;novel;Outcome;Pathway interactions;pediatric trauma;Phase;physical conditioning;Policies;Population;Population Study;Predictive Factor;Prevalence;prevent;Prevention;Public Health;Race;racial disparity;racial minority;racial population;recruit;Research;Research Activity;Research Personnel;restraint;Safety;Severities;Side;skills;social;Societies;Source;Strategic Planning;stress disorder;Structure;Surveys;System;Techniques;Technology;therapy development;Training;Training Activity;Transportation;Traumatic injury;Treatment Factor;Vehicle crash;Visualization;Work

PROJECT_TITLE: Identifying contributors to racial and ethnic disparities in child occupant safety

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROGRAM NARRATIVE Our Center is studying how immune responses in the lung result in production of excessive and abnormal mucus that plugs the airways and causes severe asthma. These studies will uncover new knowledge about mechanisms of asthma and help to pave the way for novel treatment approaches for this disease.

PI_NAMEs: ERLE, DAVID J (contact)

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TERMS: Address;airway epithelium;airway hyperresponsiveness;airway obstruction;Allergic Disease;Asthma;Automobile Driving;biological adaptation to stress;bronchial epithelium;Bronchoscopy;Caspase;cell bank;Cell Culture Techniques;Cell Differentiation process;Cell Physiology;Cell Separation;Cellular biology;Clinical;Clinical Research;Communication;Cystatins;cytokine;Data;Data Set;Development;Disease;endoplasmic reticulum stress;Ensure;Epithelial Cells;Epithelium;Family;Family member;Functional disorder;Gene Expression;genetic signature;Goblet Cells;Human;human model;human subject;Immune;Immune response;Impairment;Individual;inhibitor;insight;Interleukin-13;Knowledge;Lung;Measures;Mediating;Metaplasia;MicroRNAs;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;mouse model;MUC5AC gene;Mucins;Mucociliary Clearance;Mucous body substance;National Institute of Allergy and Infectious Disease;new therapeutic target;novel;novel strategies;Pathogenesis;Pathologic;Pathology;Pathway interactions;prevent;Production;Productivity;Proteins;Regulation;Research;response;Role;Sampling Studies;Secretory Cell;Severities;Severity of illness;Specimen;Structure of parenchyma of lung;Therapeutic;Work

PROJECT_TITLE: Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma


NIH_SPENDING_CATS: Asthma;Lung

PROJECT_TERMS: Advisory Committees;airway epithelium;Allergic Disease;Asthma;Biocompatible Materials;Budgets;career;Clinical;Collaborations;Communication;Ensure;Expenditure;experience;Functional disorder;Funding;Funding Opportunities;Human Resources;Immune;Infrastructure;meetings;member;National Institute of Allergy and Infectious Disease;Preparation;programs;Progress Reports;Regulation;Research;Research Methodology;Research Personnel;symposium;synergism;United States National Institutes of Health;Visit;Work

PROJECT_TITLE: Administrative Core


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Colorectal cancer (CRC) is the third most common cancer in men and the second in women with a worldwide total of over 1.8 million new cases per year. Dietary factors play an important role in CRC because these tumors develop adjacent to the intestinal lumen and receive direct exposure to ingested nutrients, chemicals, and microbiota throughout the day. Fructose consumption is associated with CRC risk and CRC-specific mortality so this proposal will test how the major fructose metabolite, fructose 1-phosphate, alters cellular metabolism to promote tumor cell survival.

PI_NAMEs: GONCALVES, MARCUS DASILVA (contact)

PROGRAM_OFFICER_NAME: KUMAR, AMIT

PROJECT_TERMS: Adult;Binding;Biochemical;Biological Assay;cancer cell;Cell Count;Cell Density;Cell Hypoxia;Cell Survival;Cells;Cellular Metabolic Process;Chemicals;clinical development;Clinical Research;Colon;colon cancer cell line;Colorectal Cancer;colorectal cancer progression;colorectal cancer risk;combat;Consumption;cost;Data;Development;dietary;Dietary Factors;Dose;Drug Design;Drug Targeting;Eating;Ensure;Enzyme Kinetics;Enzymes;experimental study;Exposure to;Food;Fructose;fructose-1-phosphate;Future;Gene Activation;Generations;Genes;Genetic;Genetic Models;Glucose;Goals;Growth;Human;Hypoxia;hypoxia inducible factor 1;improved;Incidence;Ingestion;inhibitor;Intake;intestinal adenoma;Intestines;Isoenzymes;Isotopes;Ketohexokinase;Kinetics;Link;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediator;men;Metabolic;Metabolic syndrome;Metabolism;metabolomics;microbiota;middle age;Modality;Modeling;Molecular;mortality;mouse model;Mus;mutant;Mutation;new therapeutic target;novel therapeutics;Nutrient;Obesity;Oral;Organ;Organoids;Oxygen;Patients;pharmacologic;Physiology;Placebos;Play;pre-clinical;Process;programs;Prospective, cohort study;Protein Biochemistry;Protein Isoforms;Proteins;Public Health;Publications;Pyruvate Kinase;Recombinant Proteins;Recombinants;Role;Science;small molecule;Structure;Sucrose;sugar;Testing;Time;Tracer;Transactivation;tumor;tumor growth;tumor metabolism;Tumor Promotion;Variant;Woman

PROJECT_TITLE: Molecular Mechanisms of Fructose-induced Colorectal Cancer Cell Survival

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: MSTP Project Narrative Progress towards solving major health problems will require a steady source of well-trained new investigators who have the clinical background to appreciate major medical issues and the research skills to tackle them. Over the years, MD-PhD programs have proven to be a highly effective way to train such investigators. We seek funding to continue our highly successful MD-PhD Program at The Johns Hopkins University School of Medicine.

PI_NAMEs: COX, ANDREA L (contact)

PROGRAM_OFFICER_NAME: AIYEGBO, MOHAMMED S

PROJECT_TERMS: Medical;Scientist;Training Programs

PROJECT_TITLE: Medical Scientist Training Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Atherosclerosis;Biotechnology;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Cardiovascular disease continues to be a leading cause of mortality, despite effective therapies available for known risk factors such as high cholesterol and high blood pressure. This proposal uses a genetic approach to understand the mechanism by which the gene TSPAN14 is involved in coronary disease, and thus may reveal new therapeutic targets. We will use cell and animal models to understand how genetic variation between humans control the function of this unstudied gene in healthy and diseased blood vessels.

PI_NAMEs: LEE-KIM, VIVIAN  (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: activation-induced cytidine deaminase;Adaptor Signaling Protein;Address;Advisory Committees;Affect;Alleles;Animal Model;Apoptosis;Architecture;Basement membrane;Binding;Binding Sites;Bioinformatics;Biological;Biological Process;Biology;Blood Vessels;Cardiovascular Diseases;causal variant;CD36 gene;Cell membrane;Cell model;cell type;Cells;Cholesterol;Chromatin;Chromosomes;Committee Members;Complement;Complex;Coronary Arteriosclerosis;Coronary heart disease;Data;Dedications;Development;Diabetes Mellitus;differential expression;Disease;disorder risk;DNA;effective therapy;Endothelial Cells;Endothelium;Enhancers;epigenetic regulation;epigenomic profiling;epigenomics;Extracellular Matrix;Fostering;Future;Gene Expression;Gene Expression Regulation;Gene Targeting;Genes;Genetic;genetic approach;Genetic Enhancer Element;Genetic Predisposition to Disease;Genetic Variation;genome editing;genome wide association study;genomic locus;Grant;Growth;Hematological Disease;Heritability;Human;Hyperlipidemia;Hypertension;Immune;in vivo;insight;Introns;Laboratories;Lead;Macrophage;Maps;Measures;Mediating;Membrane;Membrane Microdomains;Mentors;Mesenchymal;Minor;model organism;Modeling;monocyte;mortality;new therapeutic target;notch protein;novel;novel strategies;Nucleic Acid Regulatory Sequences;Pathogenesis;Pathway interactions;Peptide Hydrolases;Phase;Population Genetics;prime editing;programs;protective effect;protein function;protein transport;Proteins;Receptor Activation;Regulation;Regulatory Element;Research;Research Personnel;response;Risk Factors;risk variant;Role;Scientist;Signal Transduction;skills;success;Supervision;Techniques;Testing;Tissues;trafficking;Training;transcription factor;transcriptome sequencing;transcriptomics;transdifferentiation;Untranslated RNA;Variant;Vascular Diseases;Vascular Endothelial Cell;Writing;Zebrafish

PROJECT_TITLE: Tspan14 expression and function in cardiovascular disease


ORG_DEPT: BIOLOGY

PHR: Project Narrative As structure dictates the function of a biomolecule, proteins that naturally transition among more than one native fold may operate as regulatory switches by adopting distinct functional folds to modulate dynamic cellular processes, as is the case for the mitotic checkpoint protein MAD2 in humans, whose defective fold-switching is often found in cancerous diseases. To grasp and further modulate protein switches inside cells requires fully understanding the co-translational folding energy landscapes that govern the pathways along which these polypeptides attempt to fold as they are being synthesized. Using single-molecule optical tweezers and an in vitro human translation system, I aim to resolve the molecular trajectories of folding for MAD2 and mutant variants as they emerge on the human ribosome in the presence of folding effectors—and complementing with the dynamic fold-switching flux of MAD2 visualized via cell imaging—to provide mechanistic insights on MAD2 protein switch repair for potential treatments in cancers and other medical applications.

PI_NAMEs: YAN, SHANNON  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Address;Adopted;Amino Acid Sequence Databases;ATP phosphohydrolase;Binding;Biochemical;Biochemistry;Biological;Biophysics;Cancerous;career;career development;Cell Cycle;Cell division;cell growth;cell growth regulation;Cell Physiology;Cells;Cellular biology;cellular imaging;Chromosomal Instability;Chromosome Segregation;Complex;conformer;Data;design;Development;Disease;Dyes;Ensure;Environment;Equilibrium;Event;functional restoration;genetic manipulation;Genomic Instability;Goals;grasp;Growth;Human;Image;imaging study;In Vitro;in vivo;insight;interdisciplinary approach;International;invention;Knowledge;laser tweezer;Malignant Neoplasms;Maps;Mechanics;Mediating;Medical;Mentorship;Metabolic Diseases;Methods;Mitosis;Mitotic;Mitotic Checkpoint;mitotic spindle checkpoint protein MAD2;Molecular;Molecular and Cellular Biology;Molecular Biology;Molecular Chaperones;Molecular Conformation;mutant;Mutation;MXI1 gene;nanobodies;nanolabel;Nature;Normal Cell;operation;optic tweezer;Pathway interactions;Pattern;Peptides;Phase;Physiological;polypeptide;Potential Energy;Prevalence;Principal Investigator;Program Development;Property;Protein Biosynthesis;protein folding;Proteins;reconstitution;Records;Regulation;repaired;Reporting;Research;Research Institute;Resolution;response;Ribosomes;Role;Route;Scheme;Shapes;Signal Transduction;single molecule;skills;Spatial Distribution;Stimulus;Structure;Surface;System;Techniques;tenure track;theories;Time;Training Programs;translation assay;Translations;tumorigenesis;Variant;Visualization;Work

PROJECT_TITLE: Co-Translational Folding of Metamorphic Proteins: Assessing Structure-Function Transitions of the Mitotic Checkpoint Protein MAD2 on the Human Ribosome Surface and in the Presence of Folding Effectors


ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

PHR: PROJECT NARRATIVE The precise mechanisms by which the positive effects of bariatric surgery are conferred to efficiently and sustainably ameliorate the symptoms and sequalae of obesity remain unclear. We will employ unique mouse models and advanced technologies to examine the molecular mechanisms by which conjugated bile acids contribute to metabolic improvement after bariatric surgery. The results of our studies will provide insights that could lead to cost-effective, non-surgical therapies for obesity and its complications.

PI_NAMEs: HUANG, WENDONG  (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: Acyltransferase;Adipocytes;Adipose tissue;Adverse effects;Amino Acids;Bacteria;bariatric surgery;Bile Acids;Bile Acids and Salts;bile salts;Body Weight decreased;Cell Death;Cells;Coenzyme A;cost;cost effective;Coupled;cyclooxygenase 2;Data;Death Rate;effective therapy;Enzymes;experimental study;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;fatty liver disease;fecal transplantation;Functional disorder;Gastrectomy;Gene Modified;glucose metabolism;glycemic control;Goals;gut bacteria;gut microbiota;Health;Hepatic;Hydrolase;Immune;improved;inhibitor;insight;Intestines;Knockout Mice;Ligase;Light;lipid metabolism;Lipolysis;Macrophage;Measures;Mediating;Mediator;Metabolic;Metabolic Diseases;Metabolism;Molecular;mouse model;Mouse Strains;Mus;new therapeutic target;non-alcoholic fatty liver disease;novel;novel strategies;Obese Mice;Obesity;obesity treatment;Outcome;oxidation;Pathway interactions;pre-clinical;Probiotics;receptor;reduce symptoms;Reporting;Research;Role;Serum;sham surgery;side effect;Signal Pathway;Signal Transduction;Sphingosine-1-Phosphate Receptor;Technology;Testing;Therapeutic;Tissues;tool;translational impact;Work

PROJECT_TITLE: Conjugated bile acids as metabolic mediators between gut and fat tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-KUDS-Y(05)]


NIH_SPENDING_CATS: Bioengineering

PHR: Narrative Statement - P30GM133894 The purpose of the P30 Resource is to provide the biomedical community with access to state- of- the-art facilities for macromolecular crystallography, small-angle x-ray scattering, and x-ray spectroscopy/imaging, tools that are essential for the study of biological systems. They enable information that is prerequisite for understanding fundamentals of life, and provide methods that are central to the development of new therapeutics for human disease. The overarching goal is to provide an integrated Resource that makes mature technologies available to a broad research community, and provides researchers with expert support in their use.

PI_NAMEs: HODGSON, KEITH O (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TERMS: absorption;Area;Automation;base;Biological;biological systems;Biomedical Research;Clinic;Collaborations;Communities;computer cluster;Computer software;computerized data processing;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;Data Collection;data quality;Dedications;Detection;detector;Development;Education and Outreach;Educational workshop;experience;experimental study;Facility Accesses;flexibility;Funding;Generations;Goals;Grant;Health;Human;human disease;Image;Individual;innovation;Institution;Instruction;instrument;instrumentation;Investments;Laboratories;Leadership;Life;Light;Measurement;Membrane Lipids;Mentors;Methodology;Methods;Molecular Biology;National Institute of General Medical Sciences;new technology;novel therapeutics;online resource;operation;outreach;outreach program;Peer Review;Performance;Privatization;Process;Productivity;programs;Recording of previous events;Research;Research Personnel;Research Project Grants;Resources;Roentgen Rays;Schools;Science;Services;Site;Source;spectroscopic imaging;Spectrum Analysis;structural biology;Structure;success;synchrotron radiation;Synchrotrons;Techniques;technological innovation;Technology;theories;Time;tool;Training;United States National Institutes of Health;web portal;web-based tool;Work;X ray spectroscopy;X-Ray Crystallography;x-ray free-electron laser

PROJECT_TITLE: A Synchrotron Radiation Structural Biology Resource


PHR: Modified Public Health Relevance Section  The rationale for these studies is that understanding the roles and requirements of hepatic fatty acid oxidation  will provide insight into basic liver physiology. Additionally, these studies will inform the role of this  central metabolic pathway in obesity and glucose tolerance. These mechanistic studies may clarify the  role of fatty acid oxidation in human pathology and lay the groundwork for clinical interventions.

PI_NAMEs: WOLFGANG, MICHAEL J. (contact)

PROJECT_TERMS: acylcarnitine;ATAC-seq;Binding Proteins;Biochemical;Biochemistry;Carnitine Palmitoyltransferase I;Catabolism;Cells;Chemicals;ChIP-seq;Clinical;conditional knockout;Coupling;Data;diet-induced obesity;Disparate;Energy Metabolism;Enzymes;epigenetic regulation;Exhibits;expectation;Extrahepatic;Fasting;fatty acid metabolism;fatty acid oxidation;fatty acid transport;Fatty Acids;Food;FRAP1 gene;Gene Expression;Genes;Genetic;Genetic Models;genetic resource;Genetic Transcription;Gluconeogenesis;Glucose Intolerance;glucose tolerance;Goals;Hepatic;Hepatocyte;Hereditary Disease;High Fat Diet;Homeostasis;Human Pathology;Hypoglycemia;in vivo;Individual;innovation;insight;Intervention;ketogenesis;Knock-out;Knockout Mice;Life;Ligands;Link;Lipids;Liver;long chain fatty acid;Mediating;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;Mitochondria;Molecular;Mus;novel;Obesity;obesity development;oxidation;Persons;Phenotype;Physiological;Physiological Adaptation;Physiology;Play;Positioning Attribute;Property;public health relevance;Regulation;resilience;Resistance;Resolution;response;Role;Shapes;Signal Transduction;Signaling Molecule;Specificity;Starvation;Testing;Tissues;tool;Transcriptional Regulation;Transgenic Mice

PROJECT_TITLE: Novel roles of hepatic fatty acid oxidation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Neurosciences;Pain Research;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE  At present there is an enormous need for new safe and efficacious treatments designed to relieve the burden of  chronic pain and substance use disorders (SUD). However, there is a deficit of scientists trained to conduct  clinical research investigating pain and SUD that can move the fields forward. In order to address this gap, we  propose the Promoting Excellence through Pain and Addiction Research Enhancement (PREPARE) Program  with the long-term goal of creating the next generation of investigators who will advance science through cutting  edge clinical research that helps relieve pain and ameliorate SUD.

PI_NAMEs: GOODIN, BUREL R. (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: addiction;Address;Age;Applied Skills;Area;biopsychosocial;career;career development;chronic pain;chronic pain management;Clinical;Clinical Research;clinical training;cost;design;Development;Development Plans;Disparity;efficacious treatment;Ensure;Ethics;experience;Funding;Goals;high standard;Inequity;Infrastructure;Intervention;Knowledge;medical schools;member;Mentors;multidisciplinary;multimodality;non-opioid analgesic;Opioid;opioid use;Outcome;Pain;Pain management;pain relief;Patients;Persons;post-doctoral training;Postdoctoral Fellow;Productivity;Program Evaluation;programs;Public Health;Recording of previous events;Records;Recovery;recruit;Reporting;Research;research and development;Research Personnel;Resources;responsible research conduct;skills;social;social health determinants;Substance Use Disorder;success;Teacher Professional Development;Training;Training Programs;Translational Research;United States;Universities;Washington;Work

PROJECT_TITLE: PRomoting Excellence through Pain and Addiction Research Enhancement (PREPARE)


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: DOVER

ORG_NAME: DELAWARE STATE UNIVERSITY

ORG_STATE: DE

PI_NAMEs: MCNAUGHTON, BRIAN RICHARD (contact)

PROGRAM_OFFICER_NAME: AMIN, SHILPA HARSHAD

PROJECT_TITLE: Investigator Development


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Flux through oxidative phosphorylation is regulated by mechanisms that are not completely understood. The proposed research will address fundamental questions on how the lipid composition of mitochondrial membrane regulates bioenergetics. Findings from these studies have implications for health and disease across multiple organ systems.

PI_NAMEs: FUNAI, KATSUHIKO  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adenocarcinoma;Affect;Affinity;Architecture;ATP Synthesis Pathway;Binding;Bioenergetics;Body System;Carnitine;cell type;Chemicals;Complex;Cone;Consumption;Crista ampullaris;diagnostic platform;Disease;electron donor;electron energy;Electron Transport;Electrons;Electrophysiology (science);energy efficiency;Exercise;exercise training;fatty liver disease;Fluorometry;Health;Impairment;improved;Inner mitochondrial membrane;Intervention;Intestines;Lipids;Liver Mitochondria;Membrane;Membrane Potentials;Microscopy;Mitochondria;mitochondrial membrane;Modeling;Mus;Muscle Mitochondria;oligomycin sensitivity-conferring protein;Outer Mitochondrial Membrane;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;Phosphatidylethanolamine;Play;Process;Prognosis;Proton-Motive Force;Protons;Pyruvate;pyruvate carrier;Reaction;Regulation;Research;Resolution;Respiration;respiratory;Role;Series;Shapes;Skeletal Muscle;Spirometry;Steatohepatitis;stem cells;Surface;Testing;Transferase;tumorigenesis;Warburg Effect

PROJECT_TITLE: PE in modulation of energy flux through OXPHOS

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: Project Narrative Cancer is the leading cause of morbidity and mortality in the US and in the world. The overall goal of the Cancer Prevention Clinical Trials Network (CP-CTNet) is to perform early phase cancer prevention clinical trials to identify safe and effective preventive agents and interventions that can advance to late phases of clinical development, to ultimately reduce the risk and burden of cancer. Working with the National Cancer Institute's Division of Cancer Prevention and the CP-CTNet Sites, the CP-CTNet Data Management, Auditing, and Coordinating Center will coordinate trans-network activities and support these early phase trials by providing expertise and resources in 1) centralized data management and reporting, 2) clinical trials auditing, and 3) administrative and logistical coordination, including expertise in clinical trials methodology and biostatistics, across CP-CTNet.

PI_NAMEs: EICKHOFF, JENS  (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Biometry;Cancer Burden;cancer prevention;carcinogenesis;clinical development;Clinical Trials;Clinical Trials Network;Community Clinical Oncology Program;data management;Data Reporting;Development;Division of Cancer Prevention;Dose;early phase trial;effective intervention;Goals;Intervention;Leg;Malignant Neoplasms;Methodology;Morbidity - disease rate;mortality;National Cancer Institute;oncology trial;Phase;phase III trial;pre-clinical;Preclinical Drug Development;prevention clinical trial;Prevention trial;Preventive;Process;Program Development;programs;Research;Resources;Risk Reduction;Role;safety assessment;Site;Toxicology

PROJECT_TITLE: CP-CTNet Coordinating Center Year 6 - Aug 1, 2024 through July 31, 2025


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Infectious Diseases;Lung;Prevention

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative Cryptococcus neoformans is a fungal pathogen that causes cryptococcal meningitis, a severe HIV-associated infection of the central nervous system. In healthy individuals, C. neoformans establishes latent infections that reactivate and cause clinical symptoms upon HIV-associated immunosuppression, yet disease manifestation differs across patients. Using a mouse model, this research will determine the continuum of patient immune responses and fungal genetic factors that influence clinical outcome towards the goal of developing novel immune-modulatory treatment strategies.

PI_NAMEs: NIELSEN, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute;Acute Disease;adaptive immune response;Address;AIDS-Related Opportunistic Infections;Alleles;Antigens;Biology;Bone Marrow;CD4 Positive T Lymphocytes;Cells;Central Nervous System Infections;Characteristics;Chimera organism;Classification;Clinical;cohort;comparative;Cryptococcal Meningitis;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;cytokine;Data;Death Rate;Desiccation;Disease;disease model;Disease Outcome;Disease Progression;disorder prevention;early childhood;Exhibits;experimental study;Exposure to;fungal genetics;fungus;Genes;genome analysis;genome wide association study;Goals;Granuloma;Growth;HIV;HIV/AIDS;Human;human disease;Immune;immune function;Immune response;Immune system;Immunocompetent;Immunocompromised Host;Immunohistochemistry;Immunologics;immunomodulatory strategy;Immunosuppression;Impairment;Individual;Infection;Infection Control;Inflammatory Response;Inhalation;Innate Immune Response;Interferon Type II;latent infection;Lead;Life;logarithm;Lung;Lymphoid Cell;Mediating;Meningitis;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mouse Strains;Mus;Myeloid Cells;Neurologic;novel;Observational Study;Outcome;pathogen;pathogenic fungus;patient population;Patients;Preventive treatment;Process;programs;Proteomics;pulmonary granuloma;Pulmonary Inflammation;recruit;Reporter;Reproduction spores;Research;response;Risk;single cell sequencing;Single Nucleotide Polymorphism;Symptoms;T-Lymphocyte Subsets;Testing;trait;translational study;treatment strategy;Virulence Factors;Yeasts

PROJECT_TITLE: Continuum of Immune Responses to Cryptococcus neoformans

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ADMINISTERING_IC: AT

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Neck Pain;Neurosciences;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Back pain is one of the most common and disabling chronic pain conditions in the United States. Most cases remain poorly managed and many sufferers face barriers to equitable care which has led to unacceptable disparities in back pain management, with Black and Hispanic Americans, as well as individuals with less education and income, experiencing poorer outcomes. This project aims to address barriers that currently exist within the healthcare system by co-developing with community stakeholders, accessible evidence-based complementary and integrative health approaches that can be offered in community settings.

PI_NAMEs: EVANS, RONI L. (contact);LEININGER, BRENT

PROGRAM_OFFICER_NAME: CHIDEYA-CHIHOTA, SEKAI RUTENDO

PROJECT_TERMS: active control;Address;Adherence;Affect;Agreement;Back;Back Pain;Behavioral;Biophysics;Black American;Caring;Chronic;Chronic disabling pain;chronic painful condition;Clinical Protocols;Clinical Trials;Cognitive;Communities;community organizations;community partners;community setting;Community Trial;Complementary Health;Complex;Coping Skills;cost;Data;Data Collection;Disparity;disparity reduction;Drug Prescriptions;Education;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;Enrollment;Equity;evidence base;Exercise;experience;experimental group;Face;Feasibility Studies;feasibility testing;follow up assessment;Future;Guidelines;Health;health disparity;Health education;health organization;Health system;Healthcare Systems;Helping to End Addiction Long-term;Hispanic Americans;improved;Income;Individual;information gathering;Injections;Institutional Review Boards;Integrative Medicine;Intervention;intervention mapping;intervention program;Low Back Pain;Measures;Methods;mindfulness;Modeling;Monitor;National Center for Complementary and Integrative Health;Neck Pain;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;Pain Disorder;Pain intensity;Pain interference;Pain management;pain outcome;pain self-management;pain-related disability;Personal Satisfaction;Persons;Phase;Population;Population Heterogeneity;Preparation;primary outcome;programs;Protocols documentation;Provider;psychologic;Psychological Factors;Randomized;randomized trial;Recommendation;recruit;relative effectiveness;Research;Research Support;Resources;Safety;secondary outcome;Secure;Self Care;Self Efficacy;Self Management;self-management program;social;social factors;Subgroup;success;System;Translations;United States;United States National Institutes of Health;usability;Videoconferencing;whole health

PROJECT_TITLE: Partners for Pain & Wellbeing Equity: A Randomized Trial of Community Supported Complementary and Integrative Health Self Management for Back Pain


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Lung cancer remains the leading cause of cancer-related deaths in the United States. While new low-dose com- puted tomography (LDCT) screening programs nationwide enable earlier detection of lung cancer, a high number of indeterminate pulmonary nodules (IPNs) are being found – many of which are benign, but still with some risk of cancer. This supplemental project aims to leverage the large collection of longitudinal clinical and imaging data on individuals who underwent LDCT as part of the National Lung Screening Trial with established cancer outcomes to identify robust longitudinal imaging biomarkers that can be used to predict malignancy, reducing overtreatment and the burden and anxiety associated with managing IPNs.

PI_NAMEs: HSU, WILLIAM ;WONG, DAVID T (contact)

PROGRAM_OFFICER_NAME: HODGES, NICHOLAS AARON

PROJECT_TERMS: Address;Algorithmic Analysis;Algorithms;Anxiety;Appearance;Benign;Biological Markers;Blood;Blood specimen;cancer diagnosis;Cancer Etiology;cancer risk;cell free DNA;Cessation of life;Characteristics;Chest;Classification;Clinical;Clinical Trials;Collection;computed tomography screening;Data;Data Analyses;Data Set;Detection;Diameter;Early Diagnosis;Early identification;follow-up;Goals;Healthcare Systems;Image;imaging biomarker;improved;Individual;Informatics;interest;Laboratory Research;learning network;liquid biopsy;Location;longitudinal analysis;low dose computed tomography;Lung;lung cancer screening;Lung nodule;Machine Learning;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Manuals;Medical History;Methods;Modeling;mortality;multimodal modeling;Natural History;neural network;Nodule;novel;Outcome;overtreatment;Parents;Participant;Patients;Physicians;Predictive Value;quantitative imaging;radiologist;Radiology Specialty;radiomics;randomized trial;Research Personnel;Resources;response;Risk;routine screening;Sample Size;Scanning;screening;screening program;segmentation algorithm;Semantics;serial imaging;Services;Shapes;Slice;Solid;Surrogate Endpoint;Techniques;Technology;Texture;Thick;Time;Tissues;Training;tumor;United States;Variant;Work

PROJECT_TITLE: Characterizing longitudinal dynamics of indeterminate pulmonary nodules using semantic, radiomic, and deep features


NIH_SPENDING_CATS: Genetics;Human Genome;Pediatric

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Cells must inherit the right number of chromosomes every time they divide. Defects in this process are the most common chromosomal abnormality in cancer cells and contribute to birth defects and other diseases. We are therefore studying the process of chromosome distribution to daughter cells when they divide to understand the basis for a number of human diseases.

PI_NAMEs: BIGGINS, SUSAN  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Aneuploidy;Biochemical;cancer cell;Cell Cycle;Cell Cycle Regulation;Cell division;Cells;Centromere;Chromosome abnormality;Chromosome Segregation;Chromosomes;Congenital Abnormality;Cytology;daughter cell;Defect;Development;Disease;Ensure;Eukaryota;Evolution;Genetic;Genome Stability;Human;human disease;in vitro Assay;Inherited;Kinetochores;Lead;Malignant Neoplasms;Microtubules;Organism;prevent;Process;Proteins;Saccharomycetales;Spontaneous abortion;Time;Weight-Bearing state;Work;Yeasts

PROJECT_TITLE: Mechanisms underlying chromosome segregation

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE In order to colonize and inhabit the human microbiome, both pathogenic and commensal microbes must adapt to withstand complex stressful conditions, such as oxygen and nutrient limitation. Investigation into how the interaction of stresses influence microbial evolution is important for a deeper understanding of the infectious disease process and can lead to future targets for antimicrobial therapies and novel approaches to disease prevention.

PI_NAMEs: BEHRINGER, MEGAN GRACE (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Using Experimental Evolution to Evaluate Environmental Effects on Microbial Mutation and Adaptation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Endocrine Disruptors;Foodborne Illness;Nutrition;Pediatric;Social Determinants of Health

ORG_CITY: HADLEY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: NARRATIVE Using edible sorbents to reduce population exposures to PFAS from contaminated food and water at the site of emergencies is a novel and practical approach. The integration of in vitro, in silico, and in vivo assays will be used to collectively characterize and validate multicomponent sorbents that are effective in reducing PFAS exposures.

PI_NAMEs: WANG, MEICHEN  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adsorption;Affinity;Amendment;Animals;Benign;Binding;Biochemistry;Biological Assay;Biological Availability;Birth Weight;Blood;Blood specimen;Body Weight;Cell model;Cells;Chemicals;Chemistry;clay;Clinical;Communities;comparative efficacy;Complement;Complex;computational chemistry;computer studies;Consumption;contaminated drinking water;Data;data-driven model;Development;Diet;dietary;Dose;dosimetry;drinking water;Drug Metabolic Detoxication;efficacy validation;Emergency Situation;Environment;environmental chemical;Environmental Pollutants;Event;exposed human population;exposure route;Exposure to;Female;Fire - disasters;first responder;Floods;Food;Food Contamination;Frequencies;Frontline worker;Gastrointestinal tract structure;Goals;Half-Life;Health;Human;Human Milk;Hurricane;immunotoxicity;in silico;In Vitro;in vitro Assay;in vivo;in vivo evaluation;Industrialization;Infant;Infertility;Ingestion;Inhalation Exposure;Intervention;Intestines;Kinetics;Legal patent;Licensing;Low Birth Weight Infant;male;Malignant neoplasm of testis;Mammalian Cell;Methods;Microbe;Micronutrients;Modeling;molecular dynamics;Montmorillonite;Mycotoxins;novel;Nutrient;Oral;Organ;Organism;Outcome;Partner in relationship;Pathway interactions;Phase;Poly-fluoroalkyl substances;Population;pregnant;Prevalence;Process;Rattus;Reaction;remediation;Renal Carcinoma;Reporting;Research;Safety;safety study;screening;simulation;Site;skills;Soil;Stomach;substance use;Surface;System;Testing;Therapeutic;Thermodynamics;Time;Toxic effect;uptake;Urine;Vulnerable Populations;Water;Work

PROJECT_TITLE: Development of edible sorbent therapies to mitigate dietary exposures to per- and polyfluoroalkyl substances (PFAS)


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Chlamydia trachomatis is the leading cause of sexually transmitted infection and elicits a major burden on reproductive health throughout the world. This project will globally define Chlamydia genes that are critical for mediating this bacterium’s ability to infect cells and establish acute and severe infections in a murine female genital tract infection model. The knowledge to be gained from these efforts will open up numerous new avenues of investigation for the field focused on determining the molecular function of proteins encoded by the essential genes, as well as potential novel therapeutics and prevention strategies.

PI_NAMEs: HEFTY, P SCOTT;HYBISKE, KEVIN  (contact)

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: Achievement;Acute;acute infection;Alleles;Area;Bacteria;Biological;Biological Models;Biology;Cells;Characteristics;Chimera organism;Chlamydia;Chlamydia Infections;Chlamydia muridarum;Chlamydia trachomatis;clinically relevant;cohort;Complex;Defect;design;Development;Essential Genes;experience;experimental study;female reproductive tract;female reproductive tract infection;Foundations;functional genomics;gene product;Generations;Genes;Genetic;Genetic Determinism;genetic manipulation;Genetic study;Genome;genome-wide;Goals;Growth;Growth and Development function;Horizontal Gene Transfer;Human;human pathogen;Hybrids;In Vitro;in vitro Assay;in vivo;Infection;Influentials;innovation;interest;Interferon Type II;Investigation;Knowledge;Lead;Libraries;Maps;Mediating;Medical History;Membrane;Membrane Proteins;microorganism;Modeling;Modernization;Molecular;mouse model;Mus;Mutagenesis;mutant;Natural History;Nature;novel therapeutics;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;Pathology;Pathway interactions;Phase;Phenotype;Play;pressure;Prevention strategy;protein function;Proteins;reproductive;Reproductive Health;reproductive tract;Research Personnel;Role;Series;Sexually Transmitted Diseases;Shapes;System;Technology;Technology Transfer;tool;Tropism;Ubiquitin;Virulence;Virulence Factors;virulence gene;With laterality;Work

PROJECT_TITLE: Functional genomics for Chlamydia


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Eating Disorders;Mental Health;Neurosciences;Nutrition;Obesity;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: PROJECT NARRATIVE The purpose of this project is to elucidate the brain circuitry responsible for addiction-like food motivation or “compulsive appetite” – an overlapping ramification of extensive drug and obesogenic diet histories – in rats. Candidate brain circuitry will be identified and validated in functional units of brain cells thought to provide the “brake” on food motivation. Our hope is that such knowledge will help developing medications for compulsive behavior, perhaps, across eating disorders and drug addiction.

PI_NAMEs: SUTO, NOBUYOSHI  (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: 3-Dimensional;addiction;adverse outcome;Affect;Alcohols;Animal Model;Appetite Regulation;Appetitive Behavior;Behavioral;Binge eating disorder;Brain;brain cell;brain circuitry;Brain region;Bulimia;Calories;Cell Nucleus;Cocaine;comorbidity;Compulsive Behavior;design;Desire for food;detection platform;Diet;Dietary History;Drug Addiction;drug craving;Drug usage;Eating;Eating Disorders;Etiology;Fatty acid glycerol esters;Food;food craving;General Population;Genetic Risk;genetic risk factor;hedonic;Homeostasis;Impairment;In Situ Hybridization;Incentives;Intake;Knowledge;Life;Link;Liquid substance;Metabolic;Methods;Motivation;neural;neural network;neurobiological mechanism;Neurons;obesogenic;optogenetics;Patients;Pharmaceutical Preparations;Pilot Projects;Publishing;Punishment;Rattus;Recording of previous events;recruit;Regulation;Research;Resistance;Rewards;Saccharin;Site;Study models;sugar;System;Testing;therapeutic target;vapor;Ventral Tegmental Area;Weight Gain

PROJECT_TITLE: Extensive drug histories result in compulsive appetite: functional identification of punishment-reactive neural network re-organization in the rostromedial tegmental nucleus