ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Rural Health;Social Determinants of Health

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Asthma is a leading cause of children’s hospitalizations, missed school days and caregivers’ missed work days that has a significant impact on low income families. We seek to increase asthma control for children with uncontrolled asthma and health disparities, in order to improve the outcomes of activity, symptoms, and reduce asthma exacerbations. We will evaluate whether two interventions, an evidence-based school asthma program and an assessment of social determinants of health, with the aid of an asthma navigator and school nurse champion can be disseminated and implemented in other school settings to reduce the risk of asthma attacks.

PI_NAMEs: CICUTTO, LISA ;HUEBSCHMANN, AMY GROTELUESCHEN;SZEFLER, STANLEY J. (contact)

PROGRAM_OFFICER_NAME: ILIAS, MALIHA R

PROJECT_TERMS: Absenteeism at work;Acceleration;Address;Adoption;Age;Area;Asthma;asthma exacerbation;Attention;Behavior;Caregivers;Caring;Child;Child Care;Childhood Asthma;Cities;Clinic;Colorado;Communication;Communities;community based participatory approach;community burden;community engaged research;cost;Data;design;Disadvantaged;Disparity;Disparity population;Dissemination and Implementation;dissemination trial;effectiveness outcome;effectiveness/implementation trial;Elements;Eligibility Determination;Emergency department visit;Ensure;Equity;ethnic minority;Evaluation;evidence base;Evidence based program;experience;Exploration, Preparation, Implementation, and Sustainment;Family;Funding;Future;Grant;Guidelines;Health;Health Care Quality Indicators;health disparity;health inequalities;high risk population;Hospitalization;Hot Spot;implementation evaluation;implementation framework;implementation outcomes;implementation research;implementation strategy;improved;improved outcome;Intervention;Investments;Low income;lower income families;Maintenance;Measures;member;Methods;metropolitan;minority student;Morbidity - disease rate;Multimedia;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Outcome;Patients;Performance;Phase;population health;Practical Robust Implementation and Sustainability Model;Primary Care;primary outcome;Process;programs;Public Health;Quality of life;racial minority;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reduce health disparities;Research Design;Research Personnel;Resources;response;Risk Reduction;Rural;school district;school health;School Nursing;Schools;screening;secondary outcome;Site;skills;social health determinants;success;Symptoms;System;Testing;Training;trial design;Work

PROJECT_TITLE: Reducing Asthma Attacks in Disadvantaged School Children with Asthma


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Diabetes;Digestive Diseases;Genetics;Pediatric;Prevention;Transplantation

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

PHR: PROJECT NARRATIVE The overall goal of this proposal is to fill a critical gap in the knowledge of the role of beta cell genetics and biomarkers on C-peptide preservation in two longitudinal cohorts of patients with new onset type 1 diabetes or those with chronic pancreatitis who have undergone total pancreatectomy with islet autotransplantation. These studies will utilize large genomic data sets and beta cell biomarkers to elucidate heterogeneity in newly diagnosed patients with type 1 diabetes and a model of patients who have undergone cell therapy treatment. Taken together, these investigations will improve our understanding of factors that influence C-peptide preservation in people with type 1 diabetes and chronic pancreatitis and will support future personalized therapy interventions.

PI_NAMEs: TRIOLO, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: AKOLKAR, BEENA

PROJECT_TERMS: Age;Antibodies;Antibody titer measurement;Autoantibodies;Autoimmune biomarker;Autoimmune Diseases;Autoimmunity;Autologous Transplantation;Basic Science;Beta Cell;Biological Markers;Blood;Body mass index;C-Peptide;career;Caring;Cell model;Cell Physiology;Cell Therapy;Cellular Stress;chronic pancreatitis;Clinical;Clinical Research;Clinical Sciences;Complications of Diabetes Mellitus;Consumption;Creatinine;Development;diabetes control;Diabetes Mellitus;diabetes risk;Diagnosis;Disease;Dose;Education;Endocrine;exome;experience;Functional disorder;Future;Genes;Genetic;Genetic Risk;genetic risk factor;genomic data;Genotype;Goals;Graft Survival;Hepatic;Heterogeneity;Home;Immune;improved;Individual;Inflammation;Insulin;insulin dependent diabetes mellitus onset;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Investigation;islet;islet autoimmunity;K-Series Research Career Programs;Knowledge;Longitudinal cohort;Measurement;Measures;Medical Care Costs;Mentored Patient-Oriented Research Career Development Award;Mentorship;Metabolic;Metabolic stress;Modeling;Morbidity - disease rate;Newly Diagnosed;novel;Observational Study;Pain;Pancreatitis;Partial Remission;Pathway interactions;Patient Selection;Patients;Peptides;personalized medicine;Persons;pre-clinical;predictive modeling;preservation;Proinsulin;prospective;Prospective cohort;Public Health;Quality of life;Research;Research Personnel;Reserve Cell;response;Risk;Risk Reduction;risk variant;Role;Source;Specific qualifier value;Stress;stressor;Structure of beta Cell of islet;Study Skills;Testing;Therapeutic Intervention;Time;Total Pancreatectomy;Training;Translational Research;Transplantation;urinary

PROJECT_TITLE: Interrogating beta cell function and heterogeneity of C-peptide preservation in patients with type 1 diabetes or chronic pancreatitis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: DE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Orphan Drug;Patient Safety;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Dry mouth due to radiation therapy is a significant toxicity experienced by many head and neck cancer patients, for which there is no effective treatment or preventative therapy. Building on our experience using mesenchymal stromal cells to treat radiation induced xerostomia, we will plan a clinical trial to test the safety of injecting minor salivary gland derived mesenchymal stromal cells (MSCs) into their salivary glands to prevent the development of long-term xerostomia after radiation therapy. It is our long-term objective to develop this innovative approach into a new and effective preventative treatment to improve the lives of our patients.

PI_NAMEs: KIMPLE, RANDALL J. (contact);MCCOY, SARA

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Academic Medical Centers;Acupuncture Therapy;Acute;Adipose tissue;Affect;Allogenic;Amifostine;Autologous;Autologous Transplantation;Bone Marrow;Cancer Center;Candy;Caring;Cell Therapy;Cells;Characteristics;Chewing Gum;Cholinergic Agonists;Clinical;Clinical Protocols;Clinical Research;clinical trial protocol;Clinical Trials;Conduct Clinical Trials;Cryopreservation;Data;Deglutition;Dental caries;Dentition;Development;Dimensions;Disease;Dysgeusia;effective therapy;emotional functioning;Ensure;Environment;Esthesia;experience;Fatigue;first-in-human;Functional disorder;Goals;Head and Neck Cancer;head and neck cancer patient;Head and neck structure;Hyperbaric Oxygen;Impairment;improved;Infection;Information Systems;Infrastructure;Injections;innovation;Institution;Interferon Type II;Lead;Licensing;Lubricants;lymph nodes;Manuals;medical schools;mesenchymal stromal cell;Minor salivary gland structure;morphogens;Mus;nutrition;Nutritional status;Outcome;Patients;Pharmaceutical Preparations;Phase;phase 1 study;phase I trial;Pilot Projects;Population;preclinical study;Preparation;prevent;Prevention;Preventive therapy;Preventive treatment;Primary Neoplasm;Procedures;Production;Public Health;Quality of life;Radiation;Radiation therapy;Recommendation;Recovery;Regenerative capacity;Reporting;research clinical testing;Research Design;Research Personnel;Resources;Role;Safety;safety testing;Saliva;saliva composition;saliva function;Salivary;Salivary Glands;side effect;Site;Sleep;Social Functioning;stem cell biology;Stimulant;Structure;success;sucking;System;Taste Perception;Technology;Therapeutic;Time;Tissues;tool;Toxic effect;United States National Institutes of Health;Universities;Water;Wisconsin;Work;Xerostomia

PROJECT_TITLE: Planning a phase I study of minor salivary gland derived autologous MSCs for prevention of long-term radiation induced xerostomia


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal injury. Markers of ongoing injury are lacking. This project is relevant to the NIH’s mission because it will investigate the mechanisms of spinal injury in this disease and develop markers of injury that can be used to enhance surgical decision making and prognostication.

PI_NAMEs: SMITH, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Age Years;Anterior;Cervical;Cervical spine;Characteristics;Chronic;Clinical;clinical care;Consensus;Decision Making;Development;dexterity;Diagnosis;Disease;Dorsal;experience;Fiber;Functional Imaging;Functional Magnetic Resonance Imaging;Goals;gray matter;Hand Strength;Health;Health Care Costs;Health Expenditures;Healthcare;Horns;Human;Image;imaging biomarker;imaging modality;Imaging technology;Impairment;improved;injured;Injury;innovation;Intervention;Lead;Magnetic Resonance Imaging;Measures;Medial;median nerve;Methodology;Mission;Modeling;Modernization;Monitor;Motor;Motor Activity;nerve injury;novel;novel marker;operation;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Play;postoperative recovery;Prognosis;prognostication;Protocols documentation;Public Health;Publications;radiological imaging;Recovery;Research;response;reticulospinal tract;Role;Sensory;Severities;Severity of illness;Spinal;Spinal Cord;spinal cord compression;Spinal Cord Diseases;Spinal cord grey matter structure;spinal cord imaging;Spinal Cord Tract;spinal cord white matter;Spinal Injuries;Standardization;Stimulus;structural imaging;surgery outcome;Symptoms;Techniques;Testing;Translating;Translations;United States National Institutes of Health;Vertebral column;white matter;white matter injury;Work

PROJECT_TITLE: Structural and functional imaging markers in Degenerative Cervical Myelopathy

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Depression;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Palliative Care;Suicide

ORG_CITY: ROCHESTER

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Providing care for a family member or friend with Alzheimer’s Disease and Related Dementias (ADRD, hereafter ‘caregivers’) is a common experience for adults in mid- and later-life and can foster experiences that are beneficial to mental health, including increased purpose and feelings of mastery, but can also lead to poor mental health—anxiety, depression, and suicide ideation. Social disconnection is a common experience among ADRD caregivers and is one of the strongest risk factors for suicide ideation, attempts, and deaths. The objective of this study is to examine three indicators of social disconnection—loneliness, low belonging), and perceived burden on others—as mechanisms that increase suicide risk in ADRD caregivers.

PI_NAMEs: VAN ORDEN, KIMBERLY ALLISON (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Activities of Daily Living;Adult;Age;Aging;aging population;Alzheimer's disease related dementia;Anxiety;Behavior;care giving burden;care recipients;Caregivers;caregiving;caregiving outcomes;Caring;Cellular Phone;Cessation of life;Child;Chronic;Conflict (Psychology);Data;Dementia;dementia care;Dementia caregivers;depressive symptoms;Disease;Ecological momentary assessment;Etiology;experience;Family;Family Caregiver;Family member;Feeling;Feeling suicidal;follow-up;Fostering;Friends;functional decline;functional status;indexing;Intervention;Intervention Studies;Interview;Knowledge;late life;Life;Link;Loneliness;Mental Depression;Mental Health;middle age;Monitor;Observational Study;Perception;Personal Satisfaction;Persons;Pilot Projects;Recording of previous events;Reporting;Research;Research Design;response;Risk Factors;Role;satisfaction;Severities;social;Spouses;stressor;suicidal behavior;suicidal risk;Suicide;theories;Variant;Work

PROJECT_TITLE: Social Connection and Suicide Risk in ADRD Caregivers


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: DURHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE The Duke Regional Biocontainment Laboratory was commissioned in 2007 as a part of a network of 12 RBLs tasked with providing state-of-the-art facilities to aid in the response emerging pathogens and pandemic preparedness. This grant will provide critical support of the RBL operational infrastructure, comprehensive training program, and enhancement of Research Support services.

PI_NAMEs: STAATS, HERMAN F (contact)

PROGRAM_OFFICER_NAME: DIAZ SAN SEGUNDO, FAYNA C

PROJECT_TERMS: Animal Disease Models;animal imaging;Animal Model;Animals;Area;Bacteriology;Basic Science;biocontainment facility;biodefense;Biological;biosafety level 3 facility;Cell Separation;Centers of Research Excellence;Collaborations;Communities;Containment;Country;Dedications;Development;Education;Emerging Communicable Diseases;emerging pathogen;Ensure;Environment;Equipment;Fee-for-Service Plans;Fees;Funding;global health;Grant;hands on instruction;Health;Home;Human;Human Resources;Image;Imaging technology;Immunology;improved;in vivo;Income;Infectious Agent;Infrastructure;Institution;instrument;Laboratories;Maintenance;medical countermeasure;medical schools;Microbiology;National Institute of Allergy and Infectious Disease;new pandemic;operation;pandemic preparedness;pandemic response;pathogen;pathogenic virus;Pathology;Plants;Play;Procedures;professional atmosphere;professor;programs;Protocols documentation;Readiness;Research;Research Personnel;Research Support;Resource Development;Resources;response;Risk;Role;Safety;Scientist;Secure;Security;Service delivery model;Services;square foot;Sterility;Structure;synergism;System;theories;Toxin;Training;Training and Infrastructure;Training Programs;Translational Research;United States National Institutes of Health;Universities;Update;Vaccine Design;Vaccines;virology;Work;Workforce Development

PROJECT_TITLE: Resources and Workforce Development for the Regional Biocontainment Laboratories


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis;Vector-Borne Diseases

PI_NAMEs: DUCKETT, COLIN S. (contact)

PROJECT_TERMS: 2019-nCoV;Alpha Virus;animal imaging;Animal Model;Applied Research;Area;Basic Science;biocontainment facility;biodefense;Biological;Biological Assay;biosecurity;Cellular Assay;Certification;Communicable Diseases;Containment;Contractor;Coronavirus;Cytomegalovirus;Dedications;design;Diagnostic;Disease Outbreaks;Ebola;Elements;Emerging infection;Ensure;Equipment;Equipment and supply inventories;Event;experience;Failure;Fee-for-Service Plans;Ferrets;Flavivirus;Funding;future pandemic;global health;Goals;Hamsters;Hemagglutination;HIV;Home;Human;immune reconstitution;Immune response;Immunology;improved;In Vitro;in vivo;Infectious Diseases Research;Influenza;influenzavirus;instrumentation;Laboratories;laboratory facility;Leadership;life span;Maintenance;Malaria;Microbiology;Mission;Molecular;multiplex assay;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel vaccines;operation;Oryctolagus cuniculus;pathogen;Pharmaceutical Preparations;Poxviridae;Process;programs;Proteins;Protocols documentation;Publications;Readiness;repaired;Research;Research Design;Research Personnel;Research Support;Resource Development;risk minimization;Safety;Schedule;Secure;Serology;Services;Societies;square foot;System;Therapeutic;Time;Training;Training Support;Translational Research;Trust;Tuberculosis;United States National Institutes of Health;Universities;Vaccines;Vendor;Viral Load result;virology;Virus;Workforce Development;Yersinia pestis;ZIKA

PROJECT_TITLE: Core 1: Facility Management, Maintenance and Operations Core


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Heart Disease;Mental Health;Nutrition;Obesity;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: DENVER

ORG_NAME: UNIVERSITY OF DENVER (COLORADO SEMINARY)

PHR: PROJECT NARRATIVE Cardiovascular disease (CVD) is the leading cause of death in the US and the origins of CVD begin early in life, however, the mechanisms by which early experiences influence CVD risk are poorly understood. This project examines whether the stress responsive hormone placental corticotrophin-releasing hormone is associated with offspring CVD risk and obesogenic eating behaviors in early childhood. Consistent with NHLBI and American Heart Association goals, these findings could elucidate a potential mechanism by which prenatal factors influence cardiovascular health and provide targets for early childhood prevention of later CVD.

PI_NAMEs: DEER, LILLYBELLE KUULEI (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: 2 year old;3 year old;Acceleration;Address;Adult;Adult Children;American Heart Association;Animal Model;Animals;Anxiety;Arterial Fatty Streak;Barker Hypothesis;Behavior assessment;Biological;Birth;Blood;Blood flow;Blood Pressure;Blood specimen;Body mass index;Brain;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular risk factor;career;Cause of Death;Child;Childhood;Chronic stress;Corticotropin-Releasing Hormone;Data;Development;Diet;Dietary intake;Doctor of Philosophy;early childhood;early experience;early life stress;Eating;Eating Behavior;eating in absence of hunger;Environment;ethnic diversity;experience;Experimental Animal Model;fetal;Fetal Development;Fetal Growth Retardation;follow-up;Food;Funding;Goals;Grant;Health behavior;high body mass index;Hormone Responsive;Human;hypothalamic-pituitary-adrenal axis;indexing;Individual;infancy;Infection;Injections;Intervention;Knowledge;Laboratories;Learning;Life;Link;Literature;longitudinal design;Low income;maternal depression;Measurement;Measures;Mentors;Mentorship;Mothers;National Heart, Lung, and Blood Institute;National Institute of Mental Health;National Research Service Awards;Nutrient;Obesity;obesity in children;obesogenic;offspring;Outcome;Parents;Pathway interactions;Physiological;Physiology;Placenta;Placental Hormones;Plasma;Play;postnatal;Pregnancy;Premature Birth;prenatal;prenatal exposure;prenatal stress;Prevalence;Prevention;Production;prospective;racial diversity;Reporting;Research;Research Personnel;response;Risk Factors;Role;Sampling;Signal Transduction;skills;Statistical Models;Stress;stressor;System;Testing;Training;United States National Institutes of Health;Universities;Visit;waist circumference;Weight Gain;Work;Writing

PROJECT_TITLE: Placental CRH and child cardiovascular disease risk and obesogenic eating behaviors

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(21)]


PI_NAMEs: ALDERMAN, SCOTT  (contact)

PROJECT_TERMS: 2019-nCoV;Alpha Virus;animal imaging;Animal Model;Applied Research;Area;Basic Science;biocontainment facility;biodefense;Biological;Biological Assay;biosecurity;Cellular Assay;Certification;Containment;Coronavirus;Cytomegalovirus;Dangerousness;Dedications;design;Diagnostic;Ebola;Education;Emerging infection;emerging pathogen;Ensure;Environment;Equipment and supply inventories;experience;Fee-for-Service Plans;Ferrets;Flavivirus;Funding;future pandemic;global health;Grant;Hamsters;hands on instruction;Heart;Hemagglutination;HIV;Home;Human;Human Resources;immune reconstitution;Immune response;Immunology;improved;In Vitro;in vivo;Individual;Influenza;influenzavirus;instrumentation;Laboratories;lens;Location;Malaria;member;Microbiology;Mission;Molecular;multiplex assay;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel vaccines;operation;Oryctolagus cuniculus;pathogen;Performance;Pharmaceutical Preparations;Poxviridae;Procedures;programs;Proteins;Protocols documentation;Publications;Readiness;Research;Research Design;Research Personnel;Research Support;Resource Development;Route;Safety;Secure;Security;Serology;Services;Site;Societies;square foot;supportive environment;theories;Therapeutic;Time;Training;Training Activity;Training Programs;Training Support;Translational Research;Tuberculosis;United States National Institutes of Health;Universities;Vaccines;Viral Load result;virology;Virus;Work;Workforce Development;Yersinia pestis;ZIKA

PROJECT_TITLE: Core 2: BSL-3 Practices Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

PHR: NARRATIVE Disease of the heart is the leading cause of death in the United States. The proposed research will help us better understand how a protein contributing to proper heart rhythm is produced in cardiac cells, while defects in its formation can lead to abnormal heart beating and sudden death.

PI_NAMEs: FLORES ALDAMA, LISANDRA  (contact)

PROGRAM_OFFICER_NAME: WEBB, STEPHANIE JOHNSON

PROJECT_TERMS: Action Potentials;Affect;Affinity;Arrhythmia;Behavior;behavior in vitro;Binding;Biogenesis;Bioinformatics;Biophysics;Calorimetry;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular system;career;Cause of Death;Cells;Complex;Data;Defect;design;Disease;disease model;Electrophysiology (science);Ethers;experimental study;Fluorescent in Situ Hybridization;General Population;Genes;Genetic Transcription;Goals;Grant;Half-Life;Health;Heart Abnormalities;Heart Diseases;heart rhythm;Hela Cells;helicase;Human;human disease;human induced pluripotent stem cells;hybrid protein;Immunoprecipitation;Impairment;In Vitro;Individual;Inherited;insight;Ion Channel;knock-down;Link;live cell imaging;Long QT Syndrome;Mediating;Mediator;Messenger RNA;Microscopy;Molecular;mortality;mRNA Stability;Mutagenesis;mutant;Mutation;Myocardium;novel;Outcome;Patients;Phase;Post-Transcriptional Regulation;posttranscriptional;Potassium;Prevalence;Probability;Process;Proteins;reconstitution;Research;ribosome profiling;RNA;RNA-Binding Proteins;Role;Shapes;single molecule;skills;Specificity;structural determinants;Structure;sudden cardiac death;Sudden Death;System;Testing;Time;Transcript;Transfection;Translations;Type 2 Long QT syndrome;United States;Ventricular;Ventricular Arrhythmia;Voltage-Gated Potassium Channel;Western Blotting;Work

PROJECT_TITLE: Biogenesis of hERG1a/1b ion channels in health and disease model cardiomyocytes


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: 2019-nCoV;Animal Experimentation;Animal Model;Animals;Antibodies;Antigens;Applied Research;Area;Award;Basic Science;biocontainment facility;biodefense;Biological Assay;Biological Markers;Cell Separation;Cells;Characteristics;Chikungunya virus;Clinical;Collaborations;Communities;Containment;cytokine;Cytomegalovirus;Development;Diagnostic;Disease;disease diagnostic;Ebola;Emerging infection;Ensure;Environment;Equipment and supply inventories;Evaluation;experience;Fee-for-Service Plans;Ferrets;Flow Cytometry;Francisella tularensis;Funding;global health;Goals;Hamsters;HIV;Home;Human;Immune;Immunologic Markers;Immunologic Monitoring;Immunology;Immunology procedure;Infection;Influenza;Infrastructure;Institution;Laboratories;Laboratory Animal Models;laboratory experience;Malaria;Microbiology;Mission;Modeling;mouse model;Mus;Mycobacterium tuberculosis;National Institute of Allergy and Infectious Disease;novel;novel therapeutics;novel vaccines;novel virus;operation;pathogen;pathogenic virus;Performance;Pharmaceutical Preparations;Productivity;programs;Publications;Recording of previous events;Research;Research Personnel;Research Support;Resource Development;Safety;Sampling;Secure;Services;Societies;Sorting;Source;Therapeutic;Training;Training Support;Translational Research;Tuberculosis;United States National Institutes of Health;Universities;Vaccines;Variant;Viral;virology;Virus;Workforce Development;Yellow fever virus;Yersinia pestis;ZIKA

PROJECT_TITLE: Core 3: Biocontainment Research Support Services Core


NIH_SPENDING_CATS: Aging;Urologic Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Benign Prostatic Hyperplasia (BPH) is a highly prevalent global health issue exhibited by ~50% of men by age 50, and 75% by age 80, which may be associated with bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS). Standard treatments are often ineffective in preventing disease progression and consequent urinary retention necessitating surgery. We hypothesize that aging disrupts the nitric oxide (NO•)-soluble guanylate cyclase pathway to promote the pathogenesis of BPH/BOO/LUTS, therefore the aims of this proposal are to elucidate this pathway in aged male mice and adult mice with selective CYB5R3 knockout in the prostate or bladder, and the mechanism of action underlying the therapeutic effect of soluble guanylate cyclase activator, cinaciguat.

PI_NAMEs: KANAI, ANTHONY JOHN (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 5 Alpha-Reductase Inhibitor;Adrenergic Receptor;Adult;Age;age related;aged;Aging;antagonist;Apoptosis;Asian;BAX gene;BCL2 gene;Benign Prostatic Hypertrophy;Bladder;cardiovascular effects;Cell Proliferation;cGMP production;Clinical;Clinical Research;Collagen;Combined Modality Therapy;conditional knockout;Cyclic GMP;Cyclic GMP-Dependent Protein Kinases;cytochrome b5 reductase;Data;Disease Progression;Exhibits;Experimental Models;Extracellular Matrix;Fibrosis;Finasteride;Functional disorder;global health;Health;Heme;heme a;Histologic;Hormonal;Housekeeping;Hyperplasia;Inflammation;inhibitor;Knock-out;Knockout Mice;lower urinary tract symptoms;male;Matrix Metalloproteinase Inhibitor;Matrix Metalloproteinases;Mediating;Medical;men;mimetics;Modeling;Molecular;Mus;Muscle Tonus;Myofibroblast;Nerve;Nerve Degeneration;Neuronal Plasticity;Nitric Oxide;novel;Obstruction;old mice;Operative Surgical Procedures;Oral;Outcome;overexpression;Oxidative Stress;Oxidoreductase;participant enrollment;Pathogenesis;Pathologic;Pathway interactions;Patients;Perfusion;Phenotype;phosphodiesterase V;pill;preference;pressure;prevent;Prostate;Prostatic;Prostatic hypertrophy;Prostatic Tissue;protein activation;Refractory;Reporting;response;Risk;Role;side effect;Signal Pathway;Signal Transduction;Smooth Muscle;Soluble Guanylate Cyclase;standard care;Stanolone;tadalafil;tamsulosin;Telemetry;Testing;Testosterone;Therapeutic Effect;Tissue Inhibitor of Metalloproteinase-1;Tissue Inhibitor of Metalloproteinases;Tissues;Transforming Growth Factor beta;Up-Regulation;urinary bladder neck;Urinary Retention;Urine;Urodynamics

PROJECT_TITLE: Nitric Oxide-Soluble Guanylate Cyclase Pathway as a Target for Male Bladder Outlet Obstruction and Lower Urinary Tract Symptoms in Aging

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Rare Diseases;Usher Syndrome

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative USH2A and ADGRV1 mutations are the major cause of Usher syndrome and autosomal recessive retinitis pigmentosa, two incurable retinal degenerative diseases. Our study will identify the defective cellular pathways and involved proteins in Ush2a and Adgrv1 mutant mouse retinas at young ages using both unbiased and targeted approaches. If successful, the findings of our study will provide insight into the disease mechanism underlying USH2- associated retinal degeneration.

PI_NAMEs: YANG, JUN  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Address;Adhesions;Affect;Affinity Chromatography;Age;Animals;Antibodies;Area;autosome;Biological Assay;Biological Markers;Catalytic Domain;Cell Physiology;Clinical;Co-Immunoprecipitations;Cochlea;COL6A1;Complex;Cone;Coupled;Cultured Cells;Cyclic AMP-Dependent Protein Kinases;Deafblind;Defect;Development;differential expression;Disease;early onset;effective therapy;Electroretinography;experimental study;Extracellular Matrix;Extracellular Matrix Proteins;Functional disorder;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Mutation;Genes;hearing impairment;Immunoblot Analysis;improved;In Vitro;Individual;Inherited;inherited retinal degeneration;insight;Investigation;Knockout Mice;Knowledge;Label;late-onset retinal degeneration;Light;Mass Spectrum Analysis;Mediating;Membrane;Membrane Proteins;Membrane Transport Proteins;Modeling;Molecular;Molecular Chaperones;molecular diagnostics;Multiprotein Complexes;Mus;mutant;Mutant Strains Mice;Mutation;novel marker;novel therapeutics;Pathogenicity;Pathway interactions;Patients;Persons;phosphoproteomics;Phosphorylation;Photoreceptors;postnatal;Prevalence;prevent;Protein Fragment;Protein Inhibition;protein transport;Proteins;Proteomics;Recombinants;response;Retina;Retinal Defect;Retinal Degeneration;Retinitis Pigmentosa;Role;Signal Pathway;Signal Transduction;Structure;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic target;Transfection;USH2A gene;Usher Syndrome;Usher Syndrome Type 2;V1 Receptors;Vertebrate Photoreceptors;WHRN gene;Work

PROJECT_TITLE: Disease mechanism of Usher syndrome 2

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Cognition, learning, and memory all rely on precise neurotransmission and plasticity at synapses in the brain. These processes rely on the local abundance of glutamatergic neurotransmitter receptors called AMPA receptors. This project will focus on how AMPA receptors are locally regulated by cell adhesion molecule LRRTM2, both basally and during synaptic plasticity.

PI_NAMEs: POLLITT, STEPHANIE LYNN (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: 3-Dimensional;Acute;AMPA Receptors;Architecture;Area;Binding;Biology;Brain;Bypass;career;Cell Adhesion Molecules;Cell surface;Central Nervous System;Chronic;Cognition;Collaborations;Complex;Confocal Microscopy;CRISPR/Cas technology;Data;Dendritic Spines;density;DLG4 gene;Electrophysiology (science);Engineering;Evaluation;experimental study;extracellular;Family;fascinate;Foundations;Genetic;Genomics;Glutamates;Goals;Growth;Image;Individual;Integral Membrane Protein;Knock-out;Learning;Leucine-Rich Repeat;live cell imaging;Long-Term Potentiation;loss of function;Measures;Mediating;Memory;Methods;Microscopy;Modeling;Molecular;Mutate;Mutation;nano;nanocluster;nanoscale;neural circuit;Neurons;neurotransmission;Neurotransmitter Receptor;neurotransmitter release;novel;novel strategies;operation;Peptide Hydrolases;Play;Positioning Attribute;postsynaptic;presynaptic;prevent;Process;Proteins;recruit;Regulation;Role;scaffold;Series;Signal Transduction;single molecule;Site;Structure;superresolution microscopy;Synapses;synaptic function;Synaptic Membranes;Synaptic plasticity;Synaptic Transmission;temporal measurement;Testing;Time;tool;trafficking;Transcriptional Regulation;transmission process;Vertebral column;Visualization;Work

PROJECT_TITLE: Mechanisms of cell adhesion molecule LRRTM2 in basal and potentiated synaptic signaling


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Accumulating research suggests that barriers to eliminating the persistent racial disparities in cardiovascular disease (CVD) are related to understudied structural inequality, yet this research is largely limited to descriptive associations because high quality cohort data typically lack access to novel structural determinants. This project proposes an innovative solution by leveraging high-quality structural determinants from administrative datasets linked with high-quality prospective cohort data to investigate longitudinal associations between structural determinants and racial disparities across CVD outcomes. Establishing temporality and evaluating mediators in the association between structural determinants and CVD is an important step to establishing causality and identifying modifiable structural risk factors may help design population-level interventions to target specific structural policies and practices.

PI_NAMEs: FOLLIS, SHAWNA  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acceleration;access restrictions;Accounting;Adult;Alaska Native;Alaska Native Women;American;American Indians;Award;Behavioral;Black race;Cardiovascular Diseases;cardiovascular disorder risk;career development;Censuses;Centers for Disease Control and Prevention (U.S.);Childhood;Clinical;clinical center;cohort;Cohort Studies;Community Surveys;Data;data ecosystem;data fusion;Data Science;Data Set;design;Development Plans;disease disparity;Disease Outcome;Disease Pathway;Disparity;disparity reduction;Economics;effective intervention;Epidemiology;ethnic disparity;Ethnic Origin;Etiology;experience;Faculty;follow-up;Foundations;Future;Gender;Geography;health difference;Health Policy;Health Promotion;High Risk Woman;improved;Incidence;Income;indexing;Indigenous;Individual;Inequality;innovation;intersectionality;Intervention;Knowledge;Latina;Level of Evidence;Life;Life Cycle Stages;Link;longitudinal dataset;Maps;marginalization;Measures;Mediator;Medical;Mentors;Methodology;Methods;National Heart, Lung, and Blood Institute;Neighborhoods;novel;Paper;Participant;Pathway interactions;Phase;Policies;Population;Positioning Attribute;Postmenopause;programs;prospective;Prospective cohort;Psychosocial Stress;Public Health;Publishing;Quechua;Race;racial disparity;Research;Research Personnel;residence;residential segregation;Resources;Risk;Risk Factors;Role;Scientist;segregation;Site;skills;social culture;social health determinants;social organization;social structure;social vulnerability;Source;statistics;Strategic vision;structural determinants;Structural Models;Structural Racism;Techniques;tenure track;theories;Time;Training;Woman;Women's Health

PROJECT_TITLE: Examining the Role of Structural Factors in Racial and Ethnic Disparities in Cardiovascular Disease


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Candida auris, an emerging multi-drug resistant fungal pathogen causes life-threatening infections in humans. This study will define the underlying mechanism(s) by which microbiota regulate the skin colonization of C. auris. Results from this study will expand the knowledge about how microbiota and host factors regulate C. auris, with the long-term goal of developing novel therapeutic strategies to prevent and control invasive C. auris infections.

PI_NAMEs: THANGAMANI, SHANKAR  (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;anti-fungal agents;anti-microbial peptide;Antibiotics;antimicrobial;Azoles;Bacteria;Bioinformatics;Blood;Candida;Candida auris;cathelicidin antimicrobial peptide;Cells;Centers for Disease Control and Prevention (U.S.);Classification;Clinical Treatment;Clinical Trials;Coagulase;commensal bacteria;CRISPR/Cas technology;Data;Dendritic Cells;Disease Outbreaks;Environment;Exhibits;Family suidae;FDA approved;Fungal Genes;Future;Gene Expression;Genes;genome analysis;Genus staphylococcus;Goals;Growth;gut colonization;Hospitalization;Host Defense;Human;IL17 gene;Immune;Immunologic Factors;implantable device;In Vitro;in vitro Assay;in vivo;Individual;Infection;Infectious Skin Diseases;Integration Host Factors;Intervention;ITGAX gene;Knowledge;Langerhans cell;Life;Mass Spectrum Analysis;Mediating;Metabolism;microbiota;Molecular;mortality;mouse model;Multiple Fungal Drug Resistance;Mus;novel;novel strategies;novel therapeutic intervention;Nursing Homes;pathogen;Pathogenesis;pathogenic bacteria;pathogenic fungus;Patients;Play;Polyenes;prevent;recruit;Regulation;Reporting;resident commensals;Resistance;Risk Factors;Role;Sequence Analysis;Skin;Skin colonization;skin microbiota;Skin Tissue;small molecule;Staphylococcus epidermidis;Staphylococcus hominis;Systemic infection;TACSTD1 gene;Testing;Therapeutic;Topical application;transcriptome sequencing;transmission process;Virulence Factors;Wild Type Mouse

PROJECT_TITLE: Mechanisms of Candida auris Colonization in the Skin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stroke;Unintentional Childhood Injury

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Hypoxic-ischemic brain injury of newborns is one of the major causes of permanent neurological deficits. Our proposal will improve our mechanistic understanding of mitochondrial dysfunction following hypoxic-ischemic insult in neonates.

PI_NAMEs: GALKIN, ALEXANDER ;PAVLOV, EVGENY ;TEN, VADIM S (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Ablation;Acids;Address;Adenine Nucleotides;Adult;Affect;ATP phosphohydrolase;Attenuated;Automobile Driving;Bioenergetics;Biological Assay;Biophysical Process;Biophysics;Brain;Brain Hypoxia-Ischemia;Brain Injuries;Brain Ischemia;Buffers;Cell Death;cell injury;Cells;Cessation of life;Child;Clinical;Complex;Confusion;cyclophilin D;Cyclosporine;deprivation;disability;Disease;effective therapy;Event;Failure;Genetic;Hour;Hypoxic-Ischemic Brain Injury;improved;inhibitor;Injury;Inner mitochondrial membrane;Ions;Ischemic Brain Injury;mature animal;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;mitochondrial permeability transition pore;Mitochondrial Proteins;Modeling;Modification;Mus;NADH;natural hypothermia;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonatal mice;neonate;Neurologic Deficit;neuroprotection;new therapeutic target;newborn brain injury;novel;patch clamp;Pathogenicity;Perinatal Hypoxia;Permeability;pharmacologic;preservation;prevent;Production;Property;Proton-Motive Force;Protons;Rattus;reconstitution;Recovery;Regulation;Reperfusion Therapy;Reporting;Reproducibility;Research;Respiration;Respiratory Chain;response;Role;Secondary to;Severities;SLC25A4 gene;Specific qualifier value;Stress;Structure;Structure-Activity Relationship;Testing;Therapeutic;Time;Work

PROJECT_TITLE: Mitochondrial proton leak and neonatal brain injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Lung;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: While we have significantly advanced the therapeutic options for breast cancer over the past decades, older women are still often making the difficult decision of withstanding the harsh side effects of chemotherapies and consequent severe reduction in quality of life, or not undergo treatment and have their lifespans cut short. Here, we aim to change this paradigm by defining how breast cancer metastasis interact and adapt to the old host tissue environment. Our overarching goal is to unveil novel therapeutic targets that can be effectively used to treat late-stage metastatic breast cancer in older women and thereby significantly impact their prognosis as well as quality of life.

PI_NAMEs: DA SILVA GOMES, ANA  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: active method;Adolescent;Affect;Age;age effect;age related;Aging;aging process;aging related;Basic Science;Bile Acids;Biogenesis;Biology;Biology of Aging;Blood flow;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;cancer diagnosis;cancer therapy;cancer type;cell age;Cell Extracts;Cells;chemotherapy;Chronic Obstructive Pulmonary Disease;Circulation;Clinical;Clinical Trials;comorbidity;Connective Tissue;Data;Databases;defined contribution;Diagnosis;Disease;Distal;DNA;empowerment;Enrollment;Environment;Family;FDA approved;feeding;FGF19 gene;Fibroblast Growth Factor Receptors;fitness;Gene Expression Profile;Genetic;Goals;Growth;Home;Hormone secretion;human old age (65+);Implant;improved;inhibitor;Knowledge;life span;Lipids;Lung;lung colonization;Lung Diseases;Malignant Breast Neoplasm;Malignant neoplasm of lung;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Mitochondria;mitochondrial fitness;mitochondrial metabolism;mortality;Mus;neglect;Neoplasm Metastasis;new therapeutic target;old mice;older women;Organ;Organism;Outcome;Oxygen;Patients;precision oncology;Process;Production;Prognosis;Proteins;Quality of life;receptor;Receptor Activation;receptor for advanced glycation endproducts;Reporting;Research;response;Role;side effect;Signal Transduction;success;Testing;Therapeutic;therapeutic target;Time;Tissues;Toxicity due to chemotherapy;trait;transcription factor;triple-negative invasive breast carcinoma;tumor;tumorigenesis;Vulnerable Populations;wasting;Woman;Work;young woman

PROJECT_TITLE: Adaptations of breast cancer metastasis to the aging lung

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Asian Americans are the fastest growing major racial or ethnic group in the US. The Asian American Community Cohort-New York will be a state-of-the-art cohort research infrastructure to serve as the platform to collaborate and implement innovative research in Asian Americans, particularly focusing on Korean and Chinese Americans.

PI_NAMEs: AHN, JIYOUNG  (contact);CHEN, YU

PROGRAM_OFFICER_NAME: YAN, YE

PROJECT_TERMS: Address;Adult;Age;American;Area;Asian Americans;Atherosclerosis;Behavioral;biobank;Biological;Biological Markers;Blood;Blood Vessels;cancer health disparity;Cardiometabolic Disease;Cardiovascular Diseases;cardiovascular health;Chinese;Chinese American;Clinical;clinical examination;clinically significant;cohort;Collaborations;Collection;Communities;community based participatory research;Community Outreach;Community Participation;Data;data harmonization;data sharing;Development;diet and exercise;Disease;Disparity;Endothelium;Enrollment;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;Ethnic Population;Event;experience;Extramural Activities;follow-up;Funding;Genetic;Genomics;Goals;Grant;Health;health disparity;Home;innovation;Institution;Knowledge;Korean American;Koreans;Life Style;Limited English Proficiency;Low income;marginalization;Measures;Medical Research;Metabolic Diseases;metropolitan;microbiome;microbiome research;Morbidity - disease rate;mortality;Names;Native Hawaiian or Other Pacific Islander;New York;Non-Insulin-Dependent Diabetes Mellitus;Oral;Outcome;Participant;Patient Recruitments;Persons;Population;population health;programs;Questionnaires;racial population;recruit;Recruitment Activity;Research;Research Infrastructure;research study;Retina;Science;social culture;social disparities;sociocultural determinant;Specialized Program of Research Excellence;stool sample;Surveys;United States National Institutes of Health;urban area;Urine;Work

PROJECT_TITLE: Asian American Community Cohort of the New York Metropolitan Area


ADMINISTERING_IC: OD

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: EAST LANSING

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Narrative This proposal is to provide short-term, mentored research training to students at the beginning of their veterinary training and inspire them for careers in biomedical and translational research. Veterinarians are uniquely qualified to advance health of humans, animals, and the environment via their in-depth training and knowledge in 1) population systems, food safety, and security, 2) recognition and control of infectious diseases that are transmitted among animals and humans (interspecies), and 3) spontaneous animal models of human diseases. With the additional research training that will be acquired through this program, these future veterinary-scientists will be primed to pursue scientific interrogations to address the gaps in knowledge in the animal-human-ecosystem interface and various public health challenges facing the nation and make significant contributions throughout their careers.

PI_NAMEs: EWART, SUSAN L;HEGG, COLLEEN COSGROVE (contact);YUZBASIYAN-GURKAN, VILMA

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academia;Agriculture;Area;Biology;Biomedical Research;Cardiology;career;Career Choice;comparative;design;Development;Disease;Ecology;Ecosystem;Education;education research;Environment;Evolution;experience;Fostering;Genetic;Goals;Government;Health;human disease;human model;Industry;Inflammation;Investigation;Medical Students;Medicine;Mentors;Methods;Microbe;microbial;Minority Recruitment;Mission;Oncology;Ophthalmology;Orthopedics;Pathogenesis;peer networks;Population;programs;recruit;Research;Science;Scientist;Services;Structure;student participation;Students;summer research;System;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Zoonoses

PROJECT_TITLE: Short-term biomedical research training program for veterinary students


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Patient Safety;Rehabilitation;Social Determinants of Health

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: NARRATIVE The proposed embedded pragmatic trial leverages existing data from a newly launched SNAP cross- enrollment outreach and enrollment assistance program among 900,000 Michigan Medicaid beneficiaries. The dual purposes of the study are to (1) estimate the effect of SNAP outreach and enrollment assistance on health, health care utilization and SNAP utilization among low-income adults with disability and (2) characterize the subgroups who may benefit most from the program, based on race/ethnicity, age and chronic conditions. Information from the proposed research is urgently needed to advance health equity and improve food access.

PI_NAMEs: SAMUEL, LAURA  (contact);SWENOR, BONNIELIN

PROGRAM_OFFICER_NAME: GODETTE, DIONNE

PROJECT_TERMS: 18 year old;Accident and Emergency department;Activities of Daily Living;Address;Admission activity;Adult;Advisory Committees;Age;aged;Ambulatory Care;American;arm;Attention;attenuation;Beds;beneficiary;Black race;Blindness;Chronic;Communities;community based service;Data;Diabetes Mellitus;disability;Disability outcome;Disability status;Disabled Persons;Disadvantaged;Effectiveness of Interventions;Eligibility Determination;Emergency department visit;Enrollment;Ethnic Origin;experience;Food;Food Access;food challenge;food insecurity;General Population;Goals;Health;health care service utilization;health disparity;health equity;Heart failure;Hispanic;Home;Hospital Departments;Hospitalization;Hospitals;Household;Hunger;improved;Income;Individual;Inequity;Inpatients;Intervention;Length of Stay;long-standing disparities;Low income;Lung Diseases;Measures;Mediator;Medicaid;Medicaid eligibility;Michigan;Modification;Natural experiment;Nonprofit Organizations;Nursing Homes;nutrition;Observational Study;older adult;Outcome;outreach;outreach program;Participant;Persons;Pneumonia;Policies;Population;Poverty;pragmatic study;pragmatic trial;Process;programs;public health priorities;Race;Random Allocation;Research;Subgroup;Testing;tool;Trust;United States Dept. of Health and Human Services;Waiting Lists;Work;young adult

PROJECT_TITLE: Making Enrollment a Snap for people with disabilities with a SNAP Cross-Enrollment

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE This proposed US-UK study will include a total of more than 4.75 million children, including more than 458,000 IVF-conceived children born 1991-2018 (346,000 born from fresh embryos and 112,000 born from frozen embryos), 88,000 naturally-conceived siblings, and 4.2 million naturally-conceived control children, with 80.6 million person-years of follow-up, averaging 14.4 years in the US (ranging from birth to age 22) and 18.3 years in the UK (ranging from birth to age 36). Linking IVF treatment data, birth outcomes, and cancer and mortality data for study children and their parents in the US, and additionally childhood morbidity data, and height and weight at ages 4-5 and 10-11 in the UK, this study will provide a comprehensive contemporary picture of child health after conception by in vitro fertilization.

PI_NAMEs: LUKE, BARBARA JOAN;LUPO, PHILIP  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Accounting;Acute;Adult;adverse outcome;Age;Assisted Reproductive Technology;authority;Autologous;Birth;Birth Order;Birth Weight;Cerebral Palsy;Child;Child Health;Childbirth;Childhood;Chronic Disease;Clinic;Collaborations;Conceptions;Congenital Abnormality;Country;Data;Databases;Defect;Development;Dropout;early childhood;Embryo;embryo cryopreservation;Embryo Loss;Embryo Transfer;Embryology;Environmental Risk Factor;Epigenetic Process;ethnic diversity;Ethnic Origin;experience;Fertilization;Fertilization in Vitro;fetal loss;First Births;follow-up;Follow-Up Studies;Growth;Health;heart defect;Height;high risk;Human;Individual;Infant;Intracytoplasmic Sperm Injections;Knowledge;Left;Life;Life Cycle Stages;Link;Lymphocyte Activation;Malignant neoplasm of liver;Malignant Neoplasms;Methodology;methylome;middle childhood;Morbidity - disease rate;mortality;Neonatal;neonatal morbidity;Neonatal Mortality;Neurologic;obesity in children;oocyte cryopreservation;Oocytes;Outcome;Parents;Pattern;Perinatal;perinatal outcomes;Persons;Pregnancy;Premature Mortality;Procedures;Process;Race;racial diversity;Registries;Reporting;Research;Research Personnel;respiratory;Risk;Role;Sample Size;sex;Siblings;Societies;Socioeconomic Factors;Source;Survivors;Syndrome;System;Technology;Time;Twin Multiple Birth;Weight;young adult

PROJECT_TITLE: A US-UK Collaborative Study of the Health of Children Born From In Vitro Fertilization: From Conception Through Young Adulthood

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE The aim of this project is to understand how neuronal populations in the human frontal cortex underpin the cognitive capacity for goal-directed decision-making. To make good decisions, we need to keep track of our goals, so that we can select the actions most appropriate to achieving them. We seek to understand how three key parts of the frontal lobe play a role in the process of selecting and keeping in mind goals as we make decisions and take actions. Understanding how this works is an important step toward knowing how goal- directed decision-making can go wrong in various psychiatric disorders.

PI_NAMEs: O'DOHERTY, JOHN P (contact);RUTISHAUSER, UELI

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TITLE: Probing the neural computations underlying goal-directed decision-making in humans with single-neuron recordings

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE: The majority of type 2 diabetes (T2D) cases could be prevented or reversed through successful implementation of diet and lifestyle treatment and prevention strategies, yet diet and lifestyle interventions are difficult to adhere to due to an abundance of calories in the environment, which includes calories from sugar sweetened beverages. This proposal presents a unique sub-study within an ongoing randomized controlled trial and existing population-based cohort studies aiming to explore the underlying mechanisms of how sugar- and artificially sweetened beverage consumption influence T2D risk factors; we aim to identify novel biomarkers of dietary consumption that could lead to an individualized, objective assessment of beverage intake to increase efficacy of dietary interventions for T2D prevention. The unique career development plan provides training in the design and management of RCTs, the implementation of cutting-edge multi-omic statistical analysis techniques, and scientific leadership in T2D prevention that complements the applicants current training in nutritional epidemiology, omics, and biostatistics.

PI_NAMEs: HASLAM, DANIELLE  (contact)

PROGRAM_OFFICER_NAME: SECHI, SALVATORE

PROJECT_TERMS: Address;Adherence;American;arm;Beverages;Biological;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Biometry;Body Weight;Calibration;Calories;Cardiometabolic Disease;career;career development;Clinical;clinical translation;Cohort Studies;Complementary therapies;Complex;Consumption;cost;Data;design;Development Plans;Diabetes Mellitus;Diabetes prevention;Diet;Diet Monitoring;dietary;Dietary Assessment;Dietary intake;Dietary Intervention;Disease;disorder risk;Effectiveness;Ensure;Environment;Environmental Risk Factor;Epidemiology;epidemiology study;experience;Follow-Up Studies;Foundations;Funding;Genetic;Goals;gut microbiome;Health Professional;Healthcare Systems;high risk;improved;Individual;Inflammation;innovation;Intake;Interdisciplinary Study;Intervention Studies;Intervention Trial;K-Series Research Career Programs;Leadership;life span;Life Style;lifestyle intervention;Link;Lipids;Machine Learning;Measures;Mentorship;Metabolic;Methods;Monitor;multiple omics;National Institute of Diabetes and Digestive and Kidney Diseases;Network-based;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel;novel marker;Nurses' Health Study;nutritional epidemiology;Obesity;Participant;Pathway interactions;Patient Self-Report;Pattern;Phenotype;Plasma;Plasma Proteins;population based;precision nutrition;prevent;Prevention;Prevention strategy;protein biomarkers;protein metabolite;Proteomics;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Design;Research Personnel;response;Risk Factors;Sampling;Scientist;screening;skills;Solid;Source;Statistical Data Interpretation;Strategic Planning;success;sugar;Sugar Substitute;sweetened beverage;Techniques;Technology;Testing;tool;Training;treatment strategy;United States;United States National Institutes of Health;Validation;Water

PROJECT_TITLE: Proteomic and integrative omic profiles of sugar- and artificially sweetened beverage consumption and changes in type 2 diabetes risk factors


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research

PHR: The AT(N) framework has been validated to reflect AD pathophysiology, and operationalized postmortem and antemortem, with critical contributions from our group, however, its translation to blood remains challenging. While plasma Aβ42/Aβ40 and p-tau address the A and T aspects of the AT(N) framework in blood, an AD-specific N marker is lacking because neither plasma t-tau nor NfL – the current N markers in blood – predicts AD pathology at autopsy, associates with plaque and tangle pathology, or differentiates AD from non-ADs. The public health significance of the proposed research is that it will improve the specificity and accuracy of blood biomarkers by enabling a complete set of A, T, and N markers that that are specific to AD pathophysiology, and also validated in diverse communities including those most impacted by AD but have received the least resources in AD research and care.

PI_NAMEs: KARIKARI, THOMAS K (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;Affect;Agreement;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;Amyloid beta-42;Amyloid beta-Protein;Autopsy;beta amyloid pathology;Biological;Biological Assay;Biological Markers;Blood;Brain;Brain region;brain volume;Canada;Caring;Cerebrospinal Fluid;Clinical;clinical diagnosis;clinical diagnostics;Clinical Research;Clinical Trials;Cognition;cognitive change;cohort;Communities;cost;Data;Data Set;Dementia;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic value;ethnic diversity;Ethnic Origin;Ethnic Population;Evaluation;Functional disorder;Future;Goals;improved;in vivo;interest;Light;Measures;Modality;Nerve Degeneration;Neurofibrillary Tangles;neurofilament;neuroimaging;neuroimaging marker;Neuronal Injury;Neurons;neuropathology;novel;novel strategies;Outcome;Participant;Pathology;Performance;Peripheral;Plasma;Population;Process;prognostic;Protein Isoforms;Public Health;Race;racial difference;racial diversity;racial population;Research;research clinical testing;Resources;Sampling;Scheme;Severities;Signal Transduction;Specificity;Surrogate Markers;tau Proteins;tau-1;Translations;Validation;Wisconsin

PROJECT_TITLE: Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in blood

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-Q(02)M]


NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention

ORG_DEPT: NEUROLOGY

PHR: NARRATIVE Early Onset Parkinson’s disease refers to a sub-group of patients where the disease starts early in life (before the age of 50 years) and has a profound impact on most of patient’s life and on important productive years. A clear understanding of the pathogenic mechanisms of EOPD is lacking, although this is crucial for the successful design of therapeutic strategies and stratifying patients for clinical trials. The proposed research is relevant to public health because it aims to clarify the contribution of recognized important pathogenic mechanisms of Parkinson’s disease (genetics, inflammation, and alpha-synuclein accumulation) in patient with Early Onset Parkinson’s disease to help patients stratification for clinical counseling and clinical trials.

PI_NAMEs: RIBOLDI, GIULIETTA MARIA  (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: Accounting;adaptive immunity;Address;Affect;Age;Age of Onset;alpha synuclein;Architecture;Biochemical;Biological Assay;Biological Markers;Brain;career;Categories;Cells;Cerebrospinal Fluid;Clinical;Clinical Data;Clinical stratification;clinical subtypes;Clinical Trials;Cluster Analysis;cohort;Counseling;Data;Data Correlations;defined contribution;design;Diagnostic;Disease;disease prognosis;disorder subtype;Early identification;early onset;Eligibility Determination;Failure;Family;Family member;Frequencies;Genes;Genetic;genetic analysis;Genetic Counseling;Genetic Diseases;genetic risk assessment;genetic variant;genome sequencing;Goals;Healthcare Systems;Immune;immune activation;Immune system;improved;Incidence;Inflammation;Inflammatory;inflammatory marker;innovation;insight;Japan;Knowledge;Life;LRRK2 gene;Onset of illness;Outcome;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;patient stratification;patient subsets;Patients;Peripheral;peripheral blood;Persons;Phenotype;Play;Population;precision medicine;Preventive treatment;Productivity;prognostic;Proteins;Proteomics;Public Health;rare condition;Research;Research Proposals;Role;single cell analysis;skin biopsy;social;synucleinopathy;Therapeutic;Therapeutic Trials;therapy design;transcriptomics;trial design;Western World;whole genome

PROJECT_TITLE: Early Onset Parkinson’s disease subtypes and pathogenic mechanisms

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Complementary and Integrative Health;HIV/AIDS;Heart Disease;Infectious Diseases;Microbiome;Prevention

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Public Health Relevance Cardiovascular disease (CVD) has become a major concern in people living with HIV (PLWH). Findings of this study will advance our understanding of shared etiologies of multiple HIV-associated CVD comorbidities and provide novel insights for prevention and treatment of a range of cardiovascular disorders in PLWH that may apply to other high-risk groups. Because gut microbiota, related host immune activation and metabolic pathways are suitable for direct therapeutic intervention (e.g., prebiotics, probiotics and postbiotics, immune inhibitors), our findings may have important implications for the high public health burden of these disorders.

PI_NAMEs: BURK, ROBERT D;KIZER, JORGE R;QI, QIBIN  (contact)

PROGRAM_OFFICER_NAME: PLAYFORD, MARTIN P

PROJECT_TERMS: Affect;age related chronic disease;Algorithms;antiretroviral therapy;arterial stiffness;Atherosclerosis;Bacteria;Biological;Blood Vessels;Cardiac;Cardiology;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Carotid Arteries;Carotid Artery Plaques;Carotid Atherosclerotic Disease;CCL25 gene;CD4 Lymphocyte Count;Cells;chemokine;Chronic;Clinical;cohort;Cohort Studies;comorbidity;Data;Development;Disease;Echocardiography;Epidemiology;Etiology;follow-up;Functional disorder;Fusobacterium;Future;Gene Expression;gut bacteria;gut dysbiosis;gut microbiota;Heart failure;high risk population;HIV;HIV Infections;Human;Imidazole;Immune;immune activation;Immunologic Markers;Immunologics;Immunology;improved;Indoles;Inflammation;Inflammatory;inhibitor;innovation;insight;interdisciplinary approach;Intervention;Left;Ligands;Link;Measures;Mediation;member;Metabolic;Metabolic Pathway;metabolic profile;metabolomics;Metagenomics;microbial;Microbiology;microbiota;Modification;monocyte;multidimensional data;multidisciplinary;multiple omics;Myocardial dysfunction;novel;Outcome;Participant;Pathogenesis;Pathway interactions;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;prebiotics;Prevention;Probiotics;Propionates;Proteomics;Public Health;public health relevance;response;Risk Factors;risk sharing;Role;Specimen;Statistical Algorithm;success;T-Lymphocyte;The Multicenter AIDS Cohort Study;Therapeutic Intervention;therapeutic target;transcriptomics;Tumor Necrosis Factor Receptor;ultrasound;Ventricular;Viremia;Volatile Fatty Acids;Woman;Women's Interagency HIV Study;Women's study;Work

PROJECT_TITLE: Multi-omic signatures of gut dysbiosis and cardiovascular comorbidities associated with HIV infection

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD);Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Newton

ORG_NAME: BIOSENSICS, LLC

PHR: PROJECT NARRATIVE  Vertebral compression fracture (VCF) is the most common type of osteoporotic fracture and is associated with increased morbidity and mortality. Only 1/3 of VCFs are symptomatic, and the remaining cases are found incidentally, highlighting the need for more rigorous screening for VCF and also identifying those at risk of VCF. Therefore, we propose to develop a cloud-based platform for automatic, opportunistic screening of CT image studies that will stand by in the central imaging data server of a hospital, investigate each non-investigated spine CT study, and flag the studies of patients that are detected to have osteoporosis or vertebra(e) at risk for fracture.

PI_NAMEs: NAZARIAN, ARA ;VAZIRI, ASHKAN  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: 3-Dimensional;Age;aging population;Alcohol consumption;Algorithms;automated analysis;Biomechanics;Body mass index;bone;Bone Density;bone mass;bone reconstruction;Caring;case finding;Chronic;Classification;Classification Scheme;Clinical;Clinics and Hospitals;cloud based;Code;Collaborations;commercialization;Compression Fracture;computed tomography screening;Computer software;Confidence Intervals;Data;Data Set;Databases;deep learning;design;Detection;Development;Diagnosis;Disease;Economic Burden;Endocrinology;Ethnic Origin;Fracture;fracture risk;Functional impairment;Future;Glucocorticoids;Health Expenditures;Hospitals;Image;image processing;imaging study;Incidental Findings;indexing;Individual;Institution;International;Israel;Length;Life Cycle Stages;Maintenance;Measures;Medical Care Costs;Medical center;Medical Device;Medical Imaging;Metabolic Bone Diseases;Metastatic Neoplasm to the Bone;Minerals;Morbidity - disease rate;mortality;Musculoskeletal;Orthopedics;Osteoporosis;osteoporosis with pathological fracture;Osteoporotic;Pain;Parents;Patients;Phase;Physicians;Preventive measure;Process;Race;Radiology Specialty;reconstruction;Recording of previous events;Reporting;Rheumatoid Arthritis;Risk;Risk Assessment;screening;Screening procedure;sex;Skeleton;Small Business Innovation Research Grant;Smoking;Software Tools;Spinal Fractures;spine bone structure;standard of care;Techniques;Technology;tool;tumor;vertebra body;Vertebral column;Work;X-Ray Computed Tomography

PROJECT_TITLE: Software Platform for Automatic, Opportunistic Screening of Vertebral Compression Fractures


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Narrative The central dogma told us that DNA makes RNA makes protein; yet, we have learned that mRNA, now being used for vaccines and other therapeutics, is more than exact copy of the DNA. Chemical changes to the RNA – called RNA processing – diversify the coding potential and stability of RNA, changing the constellation of proteins each cell makes. We aim to understand the mechanisms of RNA processing, which occur during transcription of DNA, by investigating how coupling between transcription and processing regulates gene expression in living cells.

PI_NAMEs: NEUGEBAUER, KARLA M (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Acute;Address;Architecture;Base Pairing;Behavior;beta Globin;Binding;Binding Proteins;Biochemical;Biological;Cells;Chemicals;Chemistry;Code;Coupling;DNA;Erythropoiesis;Eukaryota;Event;Excision;exosome;Gene Expression;Gene Expression Regulation;gene panel;Genes;Genetic Transcription;Globin;Goals;Grant;improved;in vivo;Individual;Introns;Knowledge;Label;Learning;Length;Link;Mammalian Cell;Mammals;Mass Spectrum Analysis;Measures;Messenger RNA;Methods;Mitosis;Modeling;mRNA Precursor;Mutate;novel;Nuclear;Nuclear RNA;Nucleotides;Oculopharyngeal Muscular Dystrophy;Output;overexpression;Phosphorylation;Point Mutation;Polymerase;Positioning Attribute;posttranscriptional;Predisposition;Proteins;recruit;Regulation;Repressor Proteins;Research;Resolution;response;RNA;RNA Folding;RNA Polymerase II;RNA Processing;RNA purification;RNA Splicing;RNA Stability;RNA-Binding Proteins;Role;Saccharomycetales;Site;species difference;Splice-Site Mutation;Spliceosomes;Structure;System;Tail;Testing;Therapeutic;Trans-Activators;Transact;Transcript;Transcription Elongation;transcription factor;Transcriptional Regulation;U1 Small Nuclear Ribonucleoprotein;Vaccines;Yeasts

PROJECT_TITLE: Cross-regulation between transcription and pre-mRNA splicing

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Health Services;Human Genome

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE This study aims to investigate facilitators and barriers to long-term equitable partnerships in genomics research between communities and research institutions. We focus on legal and organizational infrastructures and practices that shape how decisions are made, by whom, and with what consequences, and changes that can support innovative and transformative approaches to equity, benefit and justice.

PI_NAMEs: CALLIER, SHAWNEEQUA ;LEE, SANDRA SOO-JIN (contact);SHIM, JANET K

PROGRAM_OFFICER_NAME: STERLING, RENE

PROJECT_TERMS: Accountability;Address;adjudication;Agreement;Area;Attention;authority;Beneficence;benefit sharing;Biomedical Research;Communities;community involvement;community partners;community research;Complex;Data;Decision Making;Ecosystem;Equity;ethical, legal, and social implication;Ethics;evidence base;experience;Genomics;Human;Individual;Inequity;Infrastructure;innovation;Institution;Institutional Practice;Institutionalization;interest;Interview;Justice;Laws;Legal;Life Cycle Stages;Literature;Maps;Mediation;Nature;Ownership;Participant;Pattern;Persons;Phase;Policies;precision medicine;Privacy;Process;Recording of previous events;recruit;Reporting;Research;Research Personnel;Research Project Grants;Resources;Science;Shapes;social;Sorting;stakeholder perspectives;STEM research;Structure;System;theories;Trust;trustworthiness;Underrepresented Populations

PROJECT_TITLE: Just Inclusion and Equity: Negotiating Community-Research Partnerships in Genomics Research (JUSTICE)


NIH_SPENDING_CATS: Neurosciences

PHR: PROJECT NARRATIVE Learning and executing motor skills is critical for everyday life and involves precisely coordinated and modulated activity of multiple regions in the brain. This proposed study will use a combination of state-of-the- art approaches to identify how motor signals from distinct brain regions can interact and be modulated in the thalamus, a central hub within the brain. Ultimately, this study will provide insights on fundamental brain motor functions that can impact the development of new treatment approaches for motor disorders, such as Parkinson’s disease.

PI_NAMEs: ROTH, RICHARD  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Adrenergic Agents;Anatomy;Award;Basal Ganglia;Behavior;Brain;Brain imaging;Brain region;career;career development;Cerebellum;Characteristics;Development;Electrophysiology (science);experience;experimental study;Goals;Head;Image;in vivo;in vivo two-photon imaging;Individual;insight;Institution;Learning;Life;Location;locus ceruleus structure;Measures;Mentors;Molecular;Monitor;Motor;Motor Activity;motor behavior;motor control;Motor Cortex;motor disorder;motor learning;Motor Skills;Movement;Movement Disorders;Mus;Neurons;neuroregulation;novel;novel therapeutic intervention;optogenetics;Outcome;Parkinson Disease;Pattern;pharmacologic;Phase;Play;Positioning Attribute;prevent;Property;Research;Research Personnel;Role;sensor;Signal Pathway;Signal Transduction;skills;Slice;spatiotemporal;Structure;Task Performances;Testing;Thalamic structure;Training;two-photon;Viral

PROJECT_TITLE: Role of thalamic modulation in motor learning

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ED_INST_TYPE: SCH OF HOME ECON/HUMAN ECOLOGY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Rehabilitation;Social Determinants of Health

ORG_CITY: ITHACA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative The goal of the proposed work is to generate and test a VR-based intervention to improve the wellbeing and quality of life of older adults with mild cognitive impairment (MCI). This project is highly innovative as it is using a VR-based delivery method and harnesses the human capital of older individuals seeking volunteer experiences to engage in meaningful social and cognitive engagement with other older adults with MCI as intervention partners. The intervention development will apply a user-centered iterative design approach to generate and evaluate the Social Engaging Restorative Virtual Environment (SERVE), which will provide older adults with MCI an opportunity for social interaction through a variety of social and cognitively engaging collaborative activities within their own homes.

PI_NAMEs: BOOT, WALTER RICHARD;CZAJA, SARA J;KALANTARI, SALEH  (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;Adult;Age;age related;age related decline;Aging;Alzheimer's disease related dementia;Ambulatory Care;Behavior Therapy;Cognition;Cognitive;cognitive process;Collaborations;Communities;Control Groups;cost effective;Data;Dementia;design;Development;economic cost;effective therapy;efficacious intervention;efficacy evaluation;Empirical Research;Equilibrium;experience;Family;Focus Groups;Gait;Generations;Goals;Health Expenditures;Health system;high risk;Home;human capital;Impaired cognition;improved;Individual;innovation;Intervention;Intervention Studies;iterative design;learning materials;Life;Literature;Loneliness;Mediating;Methods;mild cognitive impairment;older adult;Older Population;Onset of illness;Participant;Personal Satisfaction;Persons;Population;portability;Procedures;Productivity;programs;Quality of life;Randomized, Controlled Trials;remote interaction;Research;skills;social;social engagement;Social Interaction;Social isolation;Social support;societal costs;success;Technology;Testing;Theoretical model;therapy development;Training;Treatment Efficacy;usability;user centered design;Videoconferencing;virtual;virtual environment;virtual reality;virtual reality environment;virtual reality intervention;volunteer;Work

PROJECT_TITLE: A Social Engaging Restorative Virtual Environment (SERVE) Volunteer Intervention to Support Social Engagement and Well-Being in Older Adults with Cognitive Impairment


NIH_SPENDING_CATS: Aging;Biomedical Imaging;Cancer;Clinical Research;Health Services;Lung;Lung Cancer;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Lung cancer is primarily a disease of aging and is the most common cause of cancer death in the United States. Lung cancer screening can prevent lung cancer death among adults ages 50-80 with heavy smoking histories, but national guidelines disagree on who is healthy enough to justify the immediate risks of screening. This project will identify who is being screened for lung cancer across three metrics of health and determine who is most/least likely to experience harms from lung cancer screening.

PI_NAMEs: RUSTAGI, ALISON SILVIS (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Adult;Adverse event;adverse outcome;Age;Aging;aging related disease;Algorithms;American;Arrhythmia;Cancer Etiology;career;Caring;Categories;Cessation of life;Chest;Chronic Obstructive Pulmonary Disease;clinically relevant;cohort;college;comorbidity;Complication;computed tomography screening;Data;Decision Making;Diagnostic Imaging;Diagnostic Procedure;Electronic Health Record;Eligibility Determination;Ensure;Equilibrium;Ethnic Origin;Exclusion;experience;Frail Elderly;Future;Goals;Guidelines;Health;health application;health data;Health Status;Health system;high risk;improved;Individual;innovation;Intervention;Intuition;Joints;Knowledge;late life;Life;Life Expectancy;Logistic Regressions;Lung;lung cancer screening;lung imaging;Malignant neoplasm of lung;Measures;Mentorship;Methodology;Methods;Modeling;multiple chronic conditions;Names;National Institute on Aging;Nature;novel;older adult;Outcome;Pattern;personalized decision;Physicians;Positioning Attribute;Prevalence;prevent;Preventive;Preventive Health Services;Procedures;Race;Recommendation;Research Personnel;Risk;Scanning;screening;Screening for cancer;sex;Smoking and Health Research;Smoking History;Standardization;Techniques;Testing;tool;United States;Veterans Health Administration;Woman;Work

PROJECT_TITLE: Identifying older adults who benefit from lung cancer screening


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Osteoporosis;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative/ Health Relevance Post-menopausal bone loss is an unresolved clinical problem, and a clinical trial for using beta blockers (BBs) to improve bone health has recently been funded entitled, “Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial”. We propose to test novel mechanistic hypotheses of BB treatment effect using participant-derived samples from this trial, which will enable future personalized treatment strategies and create opportunities for new drug discovery.

PI_NAMEs: LARY, CHRISTINE WOODS;MOTYL, KATHERINE JEAN (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acute;Address;ADRB1 gene;Adrenergic beta-Antagonists;Adrenergic Receptor;Atenolol;beta-2 Adrenergic Receptors;Binding;bone;Bone Density;bone health;bone loss;Bone Resorption;Cells;circulating microRNA;Clinical;Clinical Trials;Competitive Binding;CRISPR/Cas technology;Data;Development;drug discovery;efficacy evaluation;Femur;fracture risk;Funding;Future;Genes;Genetic;genetic variant;genome-wide;Genotype;Goals;Grant;HDAC4 gene;Health;Heterogeneity;Hormone replacement therapy;Human;improved;in vivo;Individual;knock-down;Link;Measures;Mediating;MicroRNAs;miRNA expression profiling;Modeling;Modification;Molecular;mRNA Expression;Mus;Neck;Norepinephrine;novel;novel therapeutics;Observational Study;Osteoblasts;Osteoclasts;Osteogenesis;Osteoporosis prevention;Outcome;overexpression;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;personalized medicine;pharmacogenetic variants;Pharmacogenetics;Postmenopausal Osteoporosis;Postmenopause;Prevention;Prevention strategy;Randomized, Controlled Trials;Receptor Signaling;Risk;Safety;Sampling;Signal Pathway;Signal Transduction;Source;Testing;treatment effect;treatment group;treatment response;treatment strategy;Variant;Viral;Woman;Women's Health

PROJECT_TITLE: Molecular and cellular mechanisms of prevention of bone loss by beta blockers


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Diabetes;Neurodegenerative;Neurosciences;Prevention

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

PHR: PROJECT NARRATIVE The impact of prediabetes on the future risk for cognitive dysfunction and Alzheimer’s Disease (AD) is of great public health significance considering that a) every 1 in 3 people in the US, including half of all adults aged 60 and older have prediabetes, and b) type 2 diabetes is a strong and consistent risk factor for AD. With the availability of accurate and reliable digital technology to detect individualized glycemic patterns and abnormalities much earlier than conventional glucose metrics, as well as cost-effective, sensitive plasma- based screening tools for early AD risk, we have an unparalleled opportunity to understand how T2DM pathophysiology accelerates cognitive decline and AD risk. The proposed research is relevant to NIA’s mission of accelerating discovery of digital biomarkers for the early detection of Alzheimer’s disease and related cognitive dysfunction.

PI_NAMEs: KHAMBATY, TASNEEM  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;age acceleration;aged;Aging;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;American;Amyloid beta-42;Amyloid beta-Protein;Behavioral Medicine;Biological;Biological Assay;Biological Markers;Blood;Brain;Clinical Research;Cognition;Cognitive;cognitive function;comorbidity;Continuous Glucose Monitor;cost effective;Data;Dementia;dementia risk;Development;Diagnosis;Diagnostic;Digital biomarker;digital technology;digital tool;digital treatment;Disease;early detection biomarkers;Early Diagnosis;Endocrinology;Epidemic;Episodic memory;executive function;experience;fasting glucose;Female;Functional disorder;Future;Geriatrics;Glucose;Glycosylated Hemoglobin;Glycosylated hemoglobin A;Goals;Hyperglycemia;Hypoglycemia;Immunoassay;Impaired cognition;Inflammation;innovation;Interdisciplinary Study;Knowledge;late life;Link;Measurement;Measures;minimally invasive;Mission;monitoring device;Neurology;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Oxidative Stress;Participant;Pathway interactions;Pattern;Persons;Plasma;Positioning Attribute;pre-clinical;Prediabetes syndrome;preservation;Prevalence;Proteins;Public Health;Research;Risk;Risk Factors;risk stratification;Role;Screening procedure;sensor;Signal Transduction;Stratification;Subcutaneous Tissue;tau-1;Technology;Time;Uncertainty;user-friendly;Variant;β-amyloid burden

PROJECT_TITLE: Glucose Variability as a Digital Biomarker for Preclinical AD Risk in Prediabetes.

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Methamphetamine;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: MANHATTAN

ORG_NAME: KANSAS STATE UNIVERSITY

ORG_STATE: KS

PHR: PROJECT NARRATIVE Goals can change over time, and it is important to adapt our actions according to our current goals. This proposal will examine changes in behavioral strategy and alterations in neuronal processing that maintain adequate decision-making when the brain areas that normally support decision-making malfunction due to prior voluntary methamphetamine taking or being passively exposed to methamphetamine. Our findings will help to understand how drug abusers may maintain adequate decision-making after drug-induced brain dysfunction, and may identify alternative behavioral strategies that could improve this decision-making after past drug use.

PI_NAMEs: PICKENS, CHARLES LEE (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Affect;American;Amphetamines;analog;Animals;Area;Behavior;Behavioral;Brain;brain dysfunction;Compensation;Cues;Cytoskeleton;Data;Decision Making;Dose;drug abuser;Drug Exposure;drug of abuse;Drug usage;Drug user;Exposure to;flexibility;Food;Functional disorder;Future;Goals;Human;Impairment;improved;Injections;Intake;Laboratories;Laboratory Animals;Lateral;Learning;Lesion;Light;Literature;Location;Long-Term Effects;Measures;Mental disorders;Methamphetamine;methamphetamine exposure;methamphetamine use;Methamphetamine use disorder;Mission;Modeling;National Institute of Drug Abuse;Nature;Nervous System Disorder;neural;neural circuit;Neurobiology;Neuronal Dysfunction;Neurons;Outcome;Performance;Persons;Pharmaceutical Preparations;pharmacologic;preservation;prevent;Process;Proteins;psychostimulant;Rattus;Research;response;Rewards;Rodent;Self Administration;Signal Transduction;stimulant exposure;Substance Use Disorder;sustained recovery;Thalamic structure;Time;Tracer;Training;Variant;Visual

PROJECT_TITLE: Behavioral compensation in goal-directed action: Long term effects of voluntary methamphetamine taking versus passive exposure

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The molecular and cellular effects of physiological stress, specifically gestational stress, on the developing oocyte remain largely unknown. However, the molecular machinery for sensing stress hormones is known to be present in the developing oocyte as it progresses through meiotic prophase 1, a process critical for generating genetic diversity and ensuring correct ploidy. This proposal aims to elucidate the mechanistic consequences of physiological stress on the developing embryonic oocyte and on reproductive fitness which has many broader implications for social determinants of health and their population wide effects across generations.

PI_NAMEs: FOECKE, MARIKO  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;Adult;Adult women;Affect;Agonist;Architecture;Behavior;Behavioral;Binding;Blood Circulation;California;career;Cell Nucleus;Cells;Chromosomes;Cognitive deficits;Competence;conditional knockout;Development;Dexamethasone;Drosophila genus;Economic Conditions;Embryo;Embryonic Development;Ensure;Environmental Risk Factor;experience;experimental study;Exposure to;Fellowship;Fertility;fetal;Fetal Development;gene repression;Generations;Genetic;Genetic Transcription;Genetic Variation;Germ Cells;Germ Lines;Glucocorticoid Receptor;Glucocorticoids;Goals;Growth;Harvest;Health;heat-shock factor 1;Heat-Shock Response;high risk;Homeostasis;Hormones;Human;hypothalamic-pituitary-adrenal axis;Immune;Impairment;improved;In Vitro;in vivo;in vivo Model;Laboratories;lung maturation;Mammals;Maps;maternal stress;Measures;Mediating;Meiosis;Memory;Mentorship;Metabolic;Molecular;mouse model;Mus;National Research Service Awards;Nematoda;neurodevelopment;Oocytes;Ovarian;Ovary;pharmacologic;Phenocopy;Physiological;Play;Ploidies;Population;pre-doctoral;Pregnancy;pregnant;Premature Birth;Process;Prophase;protein expression;Proteins;proteostasis;pup;Receptor Inhibition;Receptor Signaling;reproductive;Reproductive Biology;reproductive fitness;Research;response;Role;San Francisco;Shapes;Signal Transduction;social health determinants;social implication;socioeconomics;spatiotemporal;steroid hormone;Stress;System;Testing;theories;Three-Dimensional Imaging;Time;Training;Transcript;transcription factor;transmission process;Universities;Vulnerable Populations;Work

PROJECT_TITLE: Interrogating the Role of HSF1 in Ovarian Stress

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-B(20)L]


NIH_SPENDING_CATS: Infectious Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Human

ORG_CITY: KALAMAZOO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WESTERN MICHIGAN UNIV SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Immunoglobulin A (IgA) is most abundant immunoglobulin in the mucous of the intestine, preventing invasion of pathogens by coating bacteria, and plays important roles in the homeostasis of intestine and microbiota. Although T cell independent (TI) and T cell dependent (TD) IgA secreting cells are well appreciated, their developmental origin as to whether fetal endothelial-derived or HSC-derived remains unknown. This project aims to elucidate the different roles of IgA secreting cells based on their origins, which open a new paradigm in understanding the mucous immunity.

PI_NAMEs: YOSHIMOTO, MOMOKO  (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Adult;Affinity;Antibodies;Antigens;Autoimmune Diseases;B-cell receptor repertoire sequencing;B-Lymphocytes;Bacteria;base;Binding;Bone Marrow;CD4 Positive T Lymphocytes;Cell Lineage;Cell Physiology;Cell secretion;Cells;Characteristics;Chromium;Citrobacter rodentium;Clinical;Data;Defect;Development;Disease;Embryo;Embryonic Development;Endothelial Cells;Endothelium;enteric infection;Exclusion;fetal;fetal infection;Fetal Liver;fetal stem cell;Gene Expression;Genetic;Goals;gut homeostasis;Hematopoietic Cell Production;Hematopoietic stem cells;Heterogeneity;Homeostasis;Hypersensitivity;Immune;Immunity;immunodeficiency;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulins;in vivo;Infection;Infection prevention;Inflammatory Bowel Diseases;Injury;intestinal homeostasis;Intestinal Mucosa;Intestines;Invaded;Investigation;Knowledge;Lamina Propria;Lymphopoiesis;microbial;microbial homeostasis;microbiome;microbiota;Molecular;mouse model;Mucosal Immunity;Mucous body substance;Mus;pathogen;Pathology;Pathway interactions;Patients;Peritoneal;Play;polyclonal antibody;Positioning Attribute;Predisposition;prevent;Production;progenitor;Reaction;recurrent infection;Reporting;response;Role;segregation;selective deficiency of Immunoglobulin a;single-cell RNA sequencing;Spleen;Structure of germinal center of lymph node;Symptoms;System;T-Cell Depletion;T-Lymphocyte;Testing;Tomatoes;Transplantation;Visualization;Work

PROJECT_TITLE: Different roles of fetal- and adult-derived IgA secreting cells against GI infection


NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Public and private research funders have invested heavily in implantable neurotechnologies to improve the management of treatment-resistant conditions and ameliorate or reverse loss of function (e.g., deep brain stimulation (DBS)) systems for recovery after traumatic brain injury (TBI), disorders of consciousness, movement disorders, and psychiatric disorders such as obsessive-compulsive disorder (OCD) and depression). However, even when some research participants show marked symptom relief or gain of function in implantable neurotechnology trials, there is no way to systematically ensure post-trial access to beneficial non-FDA approved investigational devices. To address this concern, this research seeks to interrogate the post-trial access ecosystem in order to promote participant well-being and advance neuroscience by gaining a deeper understanding of participants and their care partners’ trajectory following DBS trials by conducting in-depth interviews with former participants in experimental DBS trials (e.g., TBI, OCD, depression, and Tourette syndrome (TS)), their care partners, and their local physicians as well as researchers, device manufacturers, insurance providers, and key administrative personnel (i.e., representatives of academic medical centers, FDA, public and private research sponsors) regarding challenges and opportunities for post-trial device access, clinical care, and psychosocial support, as well as the scientific possibilities of extended device access and longitudinal follow up.

PI_NAMEs: FINS, JOSEPH J.;LAZARO-MUNOZ, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Academic Medical Centers;Address;Administrative Personnel;Articulation;Attitude;BRAIN initiative;Caring;Clinical;clinical care;Consciousness Disorders;cost;Data;Data Collection;Deep Brain Stimulation;Delphi Technique;design;Devices;Disease;Distress;Ecosystem;Ensure;expectation;experience;follow-up;Follow-Up Studies;Future;gain of function;Gilles de la Tourette syndrome;Goals;Health Insurance;Impairment;Implant;implantable device;improved;Insurance;Insurance Coverage;Intervention;Intervention Trial;Interview;Investments;Learning;Life;loss of function;Maintenance;Manufacturer;Maps;Mediation;meetings;Mental Depression;Mental disorders;Movement Disorders;neural;neural implant;Neurosciences;neurotechnology;Obsessive-Compulsive Disorder;Participant;Personal Satisfaction;Persons;Physicians;Play;Policies;Privatization;Process;Provider;psychosocial;Psychosocial Assessment and Care;Recurrence;reduce symptoms;Research;Research Personnel;Resistance;Role;Stroke;success;Surveys;System;Technology Transfer;Therapeutic;Traumatic Brain Injury;Traumatic Brain Injury recovery;virtual;Withdrawal

PROJECT_TITLE: Post-trial Access, Clinical Care, Psychosocial Support, and Scientific Progress in Experimental Deep Brain Stimulation Research


ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative While obesity affects more than a third of American adults, we still do not understand how obesity changes the brain to drive feeding and further weight gain. The research proposed here is relevant to public health because it will study neural circuits that reinforce feeding and reveal how they are strengthened in obesity. This aligns with NIDDK’s mission to support research and research training focused on metabolic diseases including obesity, and will ultimately lead to more targeted therapies to prevent weight gain.

PI_NAMEs: MATIKAINEN-ANKNEY, BRIDGET  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adult;Affect;American;Amygdaloid structure;Attenuated;Behavior;Behavioral Paradigm;Brain;brain based;Brain region;Calcium;career;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Data;Development;Diet;diet-induced obesity;Disease;Dopamine D1 Receptor;effective therapy;Electrophysiology (science);experience;experimental study;feeding;Food;Functional disorder;genetic manipulation;Glutamates;Goals;Head;heart disease risk;hedonic;Hippocampus;Human;Image;Impairment;in vivo;in vivo calcium imaging;Individual;interest;knock-down;Lead;Link;Literature;Long-Term Depression;Malignant Neoplasms;Mediating;member;Mental disorders;Mentors;Mentorship;Metabolic Diseases;metabolic rate;Microscope;Mission;Modeling;Molecular;Motivation;mouse model;mu opioid receptors;multidisciplinary;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;neural;neural circuit;neuroimaging;neuromechanism;Neurons;novel;Nucleus Accumbens;Obese Mice;Obesity;obesity treatment;Opioid Receptor;optogenetics;Output;Persons;Population;Postdoctoral Fellow;presynaptic;Prevalence;prevent;programs;Property;Public Health;receptor;Research;Research Support;Research Training;reward processing;Rewards;Rodent;Source;Subgroup;Synapses;synaptic depression;Synaptic plasticity;System;targeted treatment;Technical Expertise;Testing;Thalamic structure;Thinness;Training;United States;Virus;Weight;Weight Gain

PROJECT_TITLE: Defining the neural basis for persistent obesity

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]