NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Pediatric;Primary Immunodeficiencies;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative Mutation correction in Fanconi Anemia (FA) patient-derived stem cells offers a promising therapy to treat bone marrow failure of FA patients. We will exploit the CRISPR/Cas9-mediated non-homologous end joining DNA repair pathway that is highly active in FA cells to precisely insert FANCC cDNA into the endogenous promoter of FANCC gene. This homology-independent targeted integration (HITI) approach will efficiently correct FANCC mutations and rescue the BMF phenotype of FA patient derived hematopoietic stem progenitor cells.

PI_NAMEs: TRAN, NGOC TUNG  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Alleles;Allogenic;Apoptosis;arm;Autologous;Back;Biological Assay;Bone marrow failure;cancer predisposition;CD34 gene;Cell Cycle;cell growth;cell type;Cells;Clinical;clinical application;Code;Complement;Complementary DNA;Complex;conditioning;Congenital Abnormality;congenital bone marrow failure;CRISPR correction;CRISPR/Cas technology;Data;Defect;design;Development;Disease;DNA biosynthesis;DNA Damage;DNA Integration;DNA Repair;DNA Repair Pathway;DNA Sequence;Engraftment;Face;Fanconi Anemia pathway;Fanconi's Anemia;Foundations;functional restoration;Future;gene correction;gene editing technology;gene function;gene therapy;Genes;Genetic;Genome;Goals;graft vs host disease;Hematological Disease;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemoglobinopathies;Hereditary Disease;Human;Human Cell Line;humanized mouse;Immunofluorescence Immunologic;Immunologic Deficiency Syndromes;Impairment;improved;In Vitro;in vivo;insertion/deletion mutation;interest;Interphase Cell;Knock-out;Lentivirus;Mediating;member;Mendelian disorder;Mitomycin C;Modeling;mortality;Mus;Mutate;Mutation;mutation correction;Nonhomologous DNA End Joining;Outcome;Outcome Study;Pathway interactions;patient - derived stem cells;Patients;pediatric patients;Phenotype;Pre-Clinical Model;Proliferating;promoter;Proteins;Protocols documentation;Regimen;repaired;Risk;Safety;Scientist;Second Primary Cancers;Stains;Stem cell transplant;stem cells;Subgroup;success;Symptoms;System;Systems Integration;Technology;Testing;Therapeutic;Time;transgene expression;Transplant Recipients;Transplantation;tumor;Virus Integration;Western Blotting;Xenograft Model

PROJECT_TITLE: FANCC mutation correction using homology-independent targeted integration for gene therapy of Fanconi Anemia group C

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Data Science;Genetics;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Understanding the etiology of complex diseases and categorizing patients from samples taken from easily accessible tissues (like blood) are two very important aspects that will lead to development of new precision medicine strategies. In this proposal, we plan to develop new computational methods and tools that will allow researchers to identify subphenotypes in any disease. We will apply these methods on three cohorts with thousands of patients with chronic obstructive pulmonary disease (COPD) and our results are expected to help us understand the complexities of this disease and build predictors of future development.

PI_NAMEs: BENOS, PANAGIOTIS V (contact);SCIURBA, FRANK

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;airway obstruction;Algorithms;analytical method;Area;Asthma;Biology;Blood;Cause of Death;Characteristics;chest computed tomography;Chronic Disease;Chronic Obstructive Pulmonary Disease;Classification;Clinical;Clinical Data;clinical practice;clinical subtypes;clinically relevant;cohort;Collaborations;Complex;computer framework;computerized tools;Computing Methodologies;Data;Data Collection;data integration;data modalities;data modeling;Data Set;Detection;Development;diagnostic tool;disability;Disease;Disease Management;disease model;disease phenotype;Disease Progression;disorder subtype;Enrollment;Ensure;Etiology;follow-up;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Genes;Genetic;Genetic Diseases;genetic variant;genomic data;Genomics;Graph;Health Care Costs;Image;improved;Incidence;Individual;innovation;insight;learning algorithm;Link;Machine Learning;Measurement;Medicine;Methodology;Methods;Modality;Modeling;Molecular;Molecular Target;mortality;mortality risk;multimodal data;multimodality;Multiomic Data;multiscale data;Nature;Onset of illness;Pathway interactions;Patients;Pattern;peripheral blood;personalized predictions;personalized therapeutic;Phenotype;Physiological;precision medicine;predictive modeling;prognostic tool;prognostic value;pulmonary function;Pulmonary function tests;Pulmonology;radiological imaging;Research;Research Personnel;Sampling;Science;Severities;Severity of illness;Stable Disease;success;Symptoms;Syndrome;System;Testing;Time;Tissues;Training;treatment guidelines;unsupervised learning;Validation;vector;Visit;X-Ray Computed Tomography

PROJECT_TITLE: COPD SUBTYPES AND EARLY PREDICTION USING INTEGRATIVE PROBABILISTIC GRAPHICAL MODELS R01HL157879

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Organ Transplantation;Precision Medicine;Prevention;Transplantation

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

ORG_STATE: CA

PHR: The goal of this project is to use noninvasive biomarkers to guide treatment decisions and thereby improve the health of kidney transplant (KTx) recipients. In this clinical trial with associated mechanistic studies we will determine the utility of a specific biomarker called the HLA-DR/DQ molecular mismatch to a) predict post-transplant graft function/rejection and b) to guide implementation of a change in therapy aimed at improving outcomes in KTx recipients. Along with the results of the mechanistic studies which will enhance interpretive value, the work has the potential to have a paradigm-shifting and sustained impact on the clinical care of KTx recipients.

PI_NAMEs: HEEGER, PETER SCOTT (contact);NICKERSON, PETER W

PROGRAM_OFFICER_NAME: HAYES, DEBORAH

PROJECT_TERMS: 3-Dimensional;Acute;Address;Affect;Allografting;antibody-mediated rejection;arm;Biological Markers;Biopsy;Calcineurin inhibitor;Canada;Cessation of life;Characteristics;Clinical;clinical care;Clinical Trials;cohort;design;donor-specific antibody;Enrollment;Ensure;Event;evidence base;Failure;FDA approved;fibrogenesis;follow-up;Future;Glomerular Filtration Rate;Goals;graft function;Health;HLA-DR Antigens;Human;human leukocyte antigen testing;Imaging Techniques;Immune;Immunologic Markers;Immunologics;immunosuppressed;Immunosuppression;improved;improved outcome;Infrastructure;Infusion procedures;Injury;insight;instrument;isoimmunity;kidney allograft;Kidney Transplantation;Life;Mediating;Medical;Molecular;Molecular Profiling;Morbidity - disease rate;Multicenter Studies;Multicenter Trials;Mycophenolic Acid;Neurocognitive;novel;Observational Study;Outcome;Outcome Measure;outcome prediction;Pathway interactions;Patient Outcomes Assessments;Patient Participation;Patients;peripheral blood;Phenotype;Population;post-transplant;predictive marker;Prednisone;primary endpoint;Productivity;Prognostic Marker;prospective;Prospective Studies;prospective test;Protocols documentation;racial diversity;Randomized;Randomized, Controlled Trials;Research Design;Retrospective Studies;Risk;risk stratification;Safety;secondary endpoint;Self Administration;specific biomarkers;standard of care;Stratification;subcutaneous;success;T cell receptor repertoire sequencing;T-Lymphocyte;Tacrolimus;Testing;Therapeutic;Time;Toxic effect;Transplant Recipients;Transplantation;United States National Institutes of Health;vasoconstriction;Work

PROJECT_TITLE: Assessment of Biomarker Guided CNI Substitution in Kidney Transplantation


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

PHR: Public Health Narrative Filoviruses including Ebola and Marburg Virus are among the most lethal infectious diseases and a potential bioterrorism agent, but no FDA approved treatment options are available. Filoviruses contain only seven genes with the most conserved of protein, matrix protein VP40, having multiple functions in viral assembly. Identification of key VP40 protein conformational dynamics and regulation of VP40 assembly will elucidate mechanisms by which VP40 fulfills its multiple roles and how they are affected by mutations, providing not only the basis for rational drug development targeting this intricate mechanism but also providing biophysical insights into protein-protein interactions involved in many other diseases.

PI_NAMEs: STAHELIN, ROBERT VIRGIL (contact);WIEST, OLAF G

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Affect;Affinity;Animals;Behavior;Binding;Biological Models;biophysical analysis;biophysical chemistry;Biophysical Process;biophysical properties;biophysical techniques;Biophysics;Bioterrorism;C-terminal;Cell membrane;Cells;cellular imaging;Collaborations;Communicable Diseases;Computer Analysis;Computer Models;Data;Death Rate;Deuterium;Development;dimer;Disease;Disease Outbreaks;drug development;Drug Targeting;druggable target;Ebola;Ebola virus;Equilibrium;experimental study;fascinate;FDA approved;Filament;Filovirus;Free Energy;frontier;Genes;Genetic Transcription;Genome;Grain;Grant;Human;Hydrogen;in silico;In Vitro;innovation;insight;Knowledge;Laboratories;Length;Life Cycle Stages;Link;Lipid Binding;Lipids;Mammalian Cell;Marburgvirus;Mediating;Membrane;Methods;Modeling;Molecular;Molecular Conformation;molecular dynamics;molecular scale;monomer;multitask;mutant;Mutate;Mutation;Mutation Detection;N-terminal;new therapeutic target;pathogen;peptidomimetics;Process;Property;Protein Analysis;Protein Conformation;protein function;protein protein interaction;protein structure;Proteins;Public Health;Regulation;Role;Side;simulation;stapled peptide;Structural Models;Structure;Surface;System;Testing;Time;tool;Ultracentrifugation;Validation;Viral;Viral Hemorrhagic Fevers;Viral Matrix Proteins;Viral Proteins;Virion;Virus;Virus Assembly;Virus-like particle

PROJECT_TITLE: Computational and Biophysical Analysis of the Filovirus Matrix Protein System

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: RONDEBOSCH

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF CAPE TOWN

PHR: NARRATIVE For this Research Training Program, the University of Cape Town will partner with Oregon Health & Science University to provide interdisciplinary training opportunities to develop the next generation of researchers working on aspects of fundamental data science, computational omics and imaging data science. The Training Program will place strong emphasis on training graduate students and faculty from participating African institutions, through a combination of contact and on-line teaching, research projects and internships, to foster biomedical data science research that will build critical capacity in data science and drive the development of innovative solutions to African health challenges.

PI_NAMEs: BENDOU, HOCINE  (contact);HERSH, WILLIAM R;MULDER, NICOLA ;MUTSVANGWA, TINASHE ERNEST MUZVIDZWA

PROGRAM_OFFICER_NAME: POVLICH, LAURA

PROJECT_TERMS: Address;Africa;African;Applied Research;Artificial Intelligence;Awareness;big biomedical data;biomedical data science;biomedical imaging;biomedical informatics;Biotechnology;burden of illness;career;clinical imaging;Clinical Informatics;Clinical Research;clinical translation;cohort;Collaborations;computer science;Coupled;Data Science;Data Scientist;Degree program;Development;Diagnostic;drug development;Education;Engineering;ethical, legal, and social implication;Faculty;Fostering;Future;global health;Graduate Degree;Health;Health Priorities;Healthcare;Human;improved;Industry;Informatics;Infrastructure;innovation;Institution;international center;Internships;Link;Mathematics;Mining;Multiomic Data;novel strategies;Oregon;programs;Research;Research Personnel;Research Training;Science;skills;South Africa;statistics;Students;Teacher Professional Development;Technology;Therapeutic;Training;training opportunity;Training Programs;Translational Research;Universities

PROJECT_TITLE: Computational Omics and Biomedical Informatics Program (COBIP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(70)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE HIV pre-exposure prophylaxis (PrEP) and medications for opioid use disorder (MOUD) are evidence-based interventions for HIV prevention and addiction treatment among women who inject drugs (WWID), many of whom also exchange sex, but PrEP and MOUD uptakeis low among this high-risk population. Global to local application of HIV prevention strategies provides an opportunity to implement internationally developed solutions, such as providing preventive care to female sex workers in sex work venues, in a novel way for similarly marginalized populations in the United States. We hypothesize that venue-based care will improve adherence to preventive care (e.g. PrEP and MOUD) and sexual health care (e.g. STI screening and treatment) among WWID and be seen as acceptable and less stigmatizing among this socially marginalized population.

PI_NAMEs: CORCORRAN, MARIA ANN (contact);STEWART, JENELL

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Adherence;Adopted;Adoption;AIDS prevention;Appointment;barrier to care;Biological;Buprenorphine;care systems;Caring;Cessation of life;Client;Clinic;Collaborations;community advisory board;community engagement;Consolidated Framework for Implementation Research;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Data;Data Collection;design;Development;Disease Outbreaks;Drops;Drug usage;Emergency department visit;empowerment;Environment;evidence base;Evidence based intervention;Exclusion;experience;female sex worker;gaps in access;Goals;Hair;health care delivery;health care model;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;high risk population;HIV;HIV diagnosis;HIV risk;Hospitalization;Hour;housing instability;improved;Inequity;Infection;Infection Control;informant;Injecting drug user;injection drug use;innovation;International;Intervention;Interview;Laboratories;Location;low and middle-income countries;marginalization;marginalized population;Measures;Medical;medication for opioid use disorder;Methods;Modeling;multidisciplinary;Needs Assessment;Neighborhoods;novel;opioid overdose;opioid use disorder;overdose death;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;point of care;point of care testing;Population;pre-exposure prophylaxis;premature;prescription opioid;prevent epidemics;Prevention;prevention service;Prevention strategy;Preventive care;preventive intervention;Primary Care;primary care clinic;primary care services;Primary Prevention;Provider;Qualitative Research;randomized trial;response;Risk;Risk Factors;Risk Reduction;Science;screening;Services;sex;Sexual Health;Sexually Transmitted Diseases;Shelter facility;Sleep;social;social stigma;Stigmatization;Surveys;Syphilis;Testing;testing services;Time;tool;transactional sex;United States;uptake;Walking;Washington;Woman;Women's mortality;women's treatment;Work

PROJECT_TITLE: Combination primary care and prevention services for women who inject drugs and exchange sex in Seattle, Washington

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We propose to study the origin of Aedes aegypti, the most important vector of human arboviruses such as yellow fever, dengue, chikungunya, and Zika., that ur research has shown originated on islands in the Southwest Indian Ocean including Madagascar. We will study their genetic diversity, relationship to other Ae. aegypti populations as well as such traits as ability to transmit human viruses, their preferred hosts for blood meals, and whether they harbor undescribed viruses that could potentially infect humans. Understanding these traits in the ancestors of the populations spreading diseases around the world will lend insights in how the species transitioned into such a dangerous insect.

PI_NAMEs: POWELL, JEFFREY R (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Address;Admixture;Aedes;Aedes aegypti genome;Africa South of the Sahara;African;Arboviruses;Biological Assay;Blood;Breeding;candidate identification;chikungunya;Chikungunya virus;Comparative Study;Culicidae;Dangerousness;Data Set;Dengue;Dengue Virus;Detection;Disease;disease transmission;disorder risk;Documentation;Evolution;experimental study;Exposure to;Female;forest;Future;Genetic;Genetic Databases;Genetic Variation;Genome;Genomics;Goals;Habitats;Historical Demography;Human;human disease;human pathogen;Indian Ocean;Indian Ocean Islands;Infection;Insecta;insight;Island;Laboratories;Madagascar;Mammals;member;Methods;Microfluidics;Morphology;multidisciplinary;Names;Natural History;novel;particle;Phylogenetic Analysis;Population;population genetic structure;Population Genetics;Protocols documentation;Recording of previous events;reproductive;Research;Resources;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Viruses;Sister;Site;Source;Surveys;System;Taxon;Taxonomy;trait;transcriptome sequencing;transmission process;vector;vector competence;Viral;virome;Virus;Work;Yellow Fever;ZIKA

PROJECT_TITLE: Comprehensive characterization of ancestral populations of the vector Aedes aegypti on Indian Ocean islands

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: Durham

ORG_NAME: SCION NEUROSTIM, LLC

ORG_STATE: NC

PHR: PROJECT NARRATIVE Parkinson’s disease dementia has very limited therapeutic options, and current treatments for motor symptoms associated with Parkinson’s disease can worsen dementia symptoms. Data from early clinical studies showed that treatments with a new non-invasive, home-use medical device improved cognition in Parkinson’s disease patients, and therefore, may address a significant unmet need. This study will examine the effect of device treatment on cognition in individuals with Parkinson’s disease dementia, representing the first-ever device therapy to treat dementia in Parkinson’s disease patients.

PI_NAMEs: FOSTER, KRISTEN KATHLEEN (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Address;Adherence;adherence rate;Adjuvant Therapy;Adult;Adverse event;Affect;aged;arm;associated symptom;blind;Bradykinesia;Brain;Brain Stem;Caregivers;Cell Nucleus;Clinic;Clinical;clinical development;clinical diagnosis;clinical outcome measures;Clinical Research;Clinical Trials;Cognition;Cognitive;cognitive function;cognitive performance;cognitive testing;Data;Data Analyses;Deep Brain Stimulation;Dementia;design;Devices;Diagnostic;Diagnostic Procedure;Dose Limiting;Double-Blind Method;Economics;Enrollment;Equilibrium;External auditory canal;External Ear;FDA approved;Functional disorder;gastrointestinal;Home;Impaired cognition;improved;Individual;Intention;Kinetics;Levodopa;lifetime risk;Medical Device;Memory;mild cognitive impairment;Moods;Morbidity - disease rate;mortality;Motor;motor deficit;motor function improvement;motor impairment;motor symptom;Neurodegenerative Disorders;Neurons;non-demented;non-motor symptom;novel;novel therapeutics;Organ;Parkinson Disease;Parkinson's Dementia;Parkinsonian Disorders;Participant;Patient Outcomes Assessments;Patients;Personal Satisfaction;Persons;Phase;Placebos;Population;Probability;Protocols documentation;Quality of life;Randomized, Controlled Trials;Regulation;Reporting;response;Rest Tremor;retention rate;Risk;rivastigmine;Safety;safety and feasibility;Self Administration;side effect;Signs and Symptoms;Site;Sleep;solid state;Standardization;Stimulus;success;Symptoms;Testing;Therapeutic;Time;TNM;treatment adherence;treatment comparison;treatment duration;urinary;Vestibular nucleus structure;vestibular system;Visit

PROJECT_TITLE: Simple, Home-use, neurostimulAtion tReatment for Parkinson's disease dEmeNtia (SHARPEN)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Activation of innate immunity by HIV-1 drives both antiviral and proinflammatory responses, and paradoxically, the latter may contribute to viral transmission and pathogenesis. We seek to unravel the molecular basis of a key innate response (cGAS pathway) activated by HIV-1 in mucosal sites of transmission. This could lead to the development of vaccine adjuvants and therapies that target HIV-1 as well as other pathogens and diseases that activate this pathway.

PI_NAMEs: CHANDA, SUMIT K;YOH, SUNNIE  (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Address;Adjuvant;Anti-viral Response;Binding;Binding Proteins;Biochemical;Capsid;CD4 Positive T Lymphocytes;Cell Nucleus;Cells;Coculture Techniques;Coupled;cytokine;Data;data integration;Dendritic Cells;Deposition;design;dimer;Dimerization;Disease;DNA;DNA biosynthesis;Environment;Equilibrium;Event;experimental study;Flow Cytometry;gastrointestinal;Gene Expression;Genetic Engineering;HIV-1;Human;Immune;immune activation;Immune system;Immunohistochemistry;In Vitro;in vivo;Infection;Inflammatory;Inflammatory Response;Innate Immune Response;innate immune sensing;insight;Interferon Type I;Knowledge;Length;Lymphoid;Lymphoid Tissue;Measures;Mechanics;Mediating;Modeling;Molecular;molecular rearrangement;mucosal site;Mucous Membrane;Mutagenesis;Natural Immunity;nonhuman primate;Outcome;pathogen;Pathogenesis;Pathology;Pathway interactions;Pattern;Periodicity;pharmacologic;polyglutamine;prevent;Proteins;Reagent;recruit;Reporting;response;Rest;Retroviridae;Rhesus;Role;Route;sensor;Shapes;Signal Transduction;Site;SIV;Structure;superresolution microscopy;Surface;System;T-Lymphocyte;targeted treatment;Testing;transcriptomics;transmission process;Vaccine Adjuvant;vaccine development;vaccine strategy;Vaccine Therapy;Variant;Viral;viral DNA;Viral Genes;Viral Pathogenesis;viral transmission;Virus

PROJECT_TITLE: Determinants of HIV-1 innate immune sensing and its role in shaping the lymphoid environment.


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Behavioral and social science data related to health are being accumulated at fast pace. Developing algorithms and tools to properly collect, store, organize, analyze, and share these data requires behavioral health scientists with expertise in data science. We will train the next generation of behavioral health data scientists in the foundations of informatics, machine learning, and statistics, through a vibrant curriculum composed of coursework, practical experience in behavioral health research projects, internships and externships.

PI_NAMEs: HEKLER, ERIC  (contact);POLITIS, DIMITRIS                ;SITAPATI, AMY MONTAGUE;WELLS, KRISTEN JENNIFER

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: behavioral and social science;Data Analytics;social science research;Training

PROJECT_TITLE: Advanced data analytics training for behavioral and social sciences research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-A(50)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Eye Disease and Disorders of Vision;Pediatric;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Hermansky-Pudlak syndrome is a group of genetic disorders that are particularly common in Puerto Rico and are characterized by oculocutaneous albinism, excessive bleeding, and in many cases a fatal lung fibrosis and/or immune deficiency. The symptoms result from the failure to form certain specialized membrane structures, or organelles, within affected cell types. This proposal uses the melanosome, a target organelle within pigment cells, as a model system to understand how the products of the genes that are disrupted in Hermansky-Pudlak syndrome patients normally function together to generate specialized organelles.

PI_NAMEs: MARKS, MICHAEL S (contact);RAPOSO, GRACA GRACA

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Adaptor Protein Complex 2;Adaptor Protein Complex 3;Adaptor Protein Complex Subunits;Adaptor Signaling Protein;Affect;Behavior;Binding;Biochemical;Biogenesis;Biological Models;Blood Platelets;Cell membrane;cell type;Cells;cohort;Complex;Coupled;Cytoplasm;Data;Dissociation;Early Endosome;Electron Microscopy;Endosomes;Enzymes;Epithelial Cells;Eye;Failure;Funding;gene product;Genes;Genetic Diseases;genetic manipulation;Goals;Grant;Hemorrhage;Hermanski-Pudlak Syndrome;Human;Hypopigmentation;Image;imaging approach;immunodeficiency;insight;Integral Membrane Protein;Kinesin;knock-down;Knock-out;Knowledge;Length;Lipids;live cell imaging;Lysosomes;Maps;Melanins;melanocyte;Melanosomes;Membrane;Microscopy;Microtubules;Molecular;Molecular Diagnosis;Motor;mouse model;Mutate;Mutation;Oculocutaneous Albinism;Organelles;Pathway interactions;Patients;phosphatidylinositol 4-phosphate;Phospholipids;Physiological;Pigment Epithelium;Pigments;Process;Protein Isoforms;Protein Sortings;Proteins;Proteomics;Puerto Rico;Pulmonary Fibrosis;rab GTP-Binding Proteins;Recycling;Role;scaffold;Secretory Vesicles;Skin;Sorting;spatiotemporal;Specificity;Structure;Structure of retinal pigment epithelium;Symptoms;System;Testing;Therapeutic;Transmembrane Transport;Tubular formation;Vision

PROJECT_TITLE: Hermansky-Pudlak syndrome and melanosome formation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Type 2 diabetes and its complications are a leading cause of morbidity and mortality worldwide and have a strong inherited basis. The proposed study will identify the specific DNA variants, genes, and the mechanisms by which they influence risk of disease and complications. The results may identify new targets for drugs and lead to improved treatments.

PI_NAMEs: CLAUSSNITZER, MELINA C;GLOYN, ANNA LOUISE;MOHLKE, KAREN L. (contact);PARKER, STEPHEN CJ

PROGRAM_OFFICER_NAME: ZAGHLOUL, NORANN

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adipose tissue;Affect;African;Alleles;analytical method;Animal Model;Biological;Biological Assay;candidate marker;Catalogs;causal variant;Cell model;cell type;Cells;Chromatin;clinical phenotype;Collaborations;Collection;Communities;Complement;Computer Analysis;computerized tools;Computing Methodologies;Data;Data Set;diabetes mellitus genetics;diabetes pathogenesis;diabetes risk;Disease;disease heterogeneity;disorder risk;Distant;DNA;DNA Sequence;Drug Targeting;East Asian;Electrophysiology (science);Environment;epigenomics;Ethnic Origin;European;Evaluation;experimental study;Frequencies;Functional disorder;functional genomics;gene regulatory network;Generations;Genes;Genetic;genetic architecture;genetic association;Genetic study;genetic variant;Genetic Variation;Genome;genome annotation;genome editing;genome wide association study;genome-wide;genome-wide analysis;genomic data;Genomics;Genotype;Gluconeogenesis;glucose uptake;Hepatic Tissue;Hepatocyte;Heritability;Hispanic;Human;Human Genetics;Impairment;improved;in vivo;Individual;Inherited;insight;Insulin;Insulin deficiency;insulin secretion;International;Investigation;islet;Islet Cell;Latino;Link;lipid metabolism;Lipids;Liver;Maps;Meta-Analysis;Methods;Mitochondria;Molecular;Morbidity - disease rate;mortality;multidisciplinary;Muscle;Muscle Cells;Names;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Nucleotides;pancreatic juice;Pathway interactions;Pharmaceutical Preparations;Physiological;Play;Population;Population Heterogeneity;protein function;Regulation;Regulatory Element;Research Personnel;Resistance;risk variant;Role;Series;Signal Pathway;Signal Transduction;skeletal tissue;South Asian;Structure of beta Cell of islet;System;Testing;therapeutic target;Tissues;trait;Transcript;transcriptomics;Translating;Untranslated RNA;Validation;Variant;Vision;Visualization

PROJECT_TITLE: Bridging the gap between type 2 diabetes GWAS and therapeutic targets


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Nanotechnology;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: Nashville

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE We propose to develop bioadhesive siRNA nanoparticles (bioad-si-NPs) for sustained RNA interference therapy to inhibit expression of MMPs (either individual MMPs or in combination). We will test this experimental therapy for blocking disease progression in both post-traumatic arthritis (PTOA) and osteoarthritis (OA) models.

PI_NAMEs: DUVALL, CRAIG LEWIS (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Affect;Age Months;Aging;aging related;Analgesics;Animal Model;Animals;Anterior Cruciate Ligament;Anti-Inflammatory Agents;Antibodies;articular cartilage;Benchmarking;Binding;Biological;Biology;Biomedical Engineering;cancer clinical trial;Cartilage;cartilage degradation;Catalytic Domain;Cavia;Chemicals;Chemistry;Clinical;clinical care;Clinical Trials;Collaborations;Collagen;Collagen Type II;collagenase;collagenase 1;collagenase 3;cytokine;Degenerative polyarthritis;design;Development;Diagnostic;Disease;Disease Progression;Doctor of Medicine;Doctor of Philosophy;Dose;Drug Delivery Systems;Drug Kinetics;drug testing;Early treatment;Euthanasia;Family suidae;Feedback;Formulation;Gene Silencing;guinea pig model;high risk;Homologous Gene;Human;Immunology;improved;In Vitro;in vivo;Individual;Inflammatory;Injury;innovation;insight;Interstitial Collagenase;Intervention;Investigational Therapies;joint function;joint injury;Joints;Knee;Knee joint;knock-down;Lead;Lesion;Life;Life Style Modification;ligament injury;Longevity;Masks;Matrix Metalloproteinases;mechanical load;Messenger RNA;Metabolic;Modeling;Molecular;Monoclonal Antibodies;Mus;nanomedicine;nanoparticle;Nanotechnology;Obesity;Outcome;Pain;pain relief;Pathogenesis;Patient Care;Patients;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacologic Substance;Polymers;Positioning Attribute;pre-clinical research;Production;Property;Proteins;Quality of life;Replacement Arthroplasty;Research Design;Resistance;response to injury;rheumatologist;Risk;RNA;RNA Interference;RNA Interference Therapy;side effect;Signal Transduction;siRNA delivery;Site;Small Interfering RNA;small molecule;small molecule inhibitor;Specificity;Steroids;Structural Protein;System;Testing;Therapeutic;therapeutic nanoparticles;Therapeutic Studies;Tissue Adhesives;Traumatic Arthropathy;treatment group;Up-Regulation;Weight;Weight-Bearing state

PROJECT_TITLE: Tissue Adhesive RNA Interference Nanoparticles to Block Progression of Posttraumatic and Spontaneous Osteoarthritis.

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NEW YORK

ORG_DEPT: CHEMISTRY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: K+ channels are life's metronomes, dictating the timing of cardiac and nervous system events, and maintaining the resting potential of essentially all membranes. The medical relevance of inactivation of channels is underscored by the fact that many promising drugs were abandoned because of adventitious binding to K+ channels in the heart, altering inactivation properties and causing acquired long QT syndrome and arrhythmias, while bacterial K+ channels and their regulatory elements are promising drug targets. We propose NMR experiments that will clarify the structure, stability, and dynamics of the activated and inactivated states of K+ channels.

PI_NAMEs: MCDERMOTT, ANN E (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Acceleration;Affinity;Amino Acid Motifs;Antibiotics;Architecture;Arrhythmia;Bacteria;base;Binding;Binding Sites;Biophysics;carbonyl group;Cardiac;Chemicals;Collection;Complex;Coupling;Data;Data Analyses;Disease;Drug Targeting;Electrophysiology (science);Event;Exhibits;experimental study;extracellular;Frequencies;Functional disorder;Funding;Grant;Health;Heart;Homologous Gene;Human;Hydration status;insight;interest;Ion Channel;Ions;Kinetics;Laboratories;Lead;Length;Life;Ligand Binding;Ligands;Location;Long QT Syndrome;Measurement;Measures;Medical;Membrane;Membrane Potentials;methicillin resistant Staphylococcus aureus;Methods;millisecond;Modeling;Molecular;Molecular Conformation;molecular dynamics;Molecular Probes;mutant;Mutation;Nervous System;Neurons;NMR Spectroscopy;pathogen;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Physiologic pulse;Potassium Channel;Process;Property;Protein Region;proteoliposomes;Protons;Regulation;Regulatory Element;Relaxation;Reporting;Research;response;Role;sensor;Sequence Analysis;Signal Transduction;small molecule;solid state nuclear magnetic resonance;Source;Structure;Testing;Thermodynamics;Time;voltage gated channel

PROJECT_TITLE: Structural and Functional Studies of Potassium Channels by Solid State NMR


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Injury;Mental Health;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Social Determinants of Health;Unintentional Childhood Injury;Violence Research;Youth Violence

ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: NARRATIVE: Children experience interpersonal violence, sexual abuse, accidents and injuries – adverse childhood experiences – but not all children exposed to these experiences develop psychopathology. These children are resilient, they may go undiagnosed, or they are able to forget about the experiences. We will study adverse childhood experiences in young rats to help develop treatments that allow these memories to be erased.

PI_NAMEs: SCHREURS, BERNARD G. (contact)

PROGRAM_OFFICER_NAME: MAHOLMES, VALERIE

PROJECT_TERMS: Accidents;Address;Adolescent and Young Adult;Adult;adverse childhood events;Adverse event;Affect;Age;age related;Amnesia;Amygdaloid structure;Animal Model;Antibiotics;Area;Association Learning;Behavior Therapy;Behavioral;Brain;Cerebellar Nuclei;Child;Childhood;Chondroitin ABC Lyase;Chondroitin Sulfate Proteoglycan;Conditioned Stimulus;critical period;Cues;Data;Development;Diagnosis;Distress;Doxycycline;Emotional;Event;experience;experimental study;Exposure to;Extinction;forgetting;Goals;Growth;Impairment;Incidence;infancy;Injury;Interpersonal Violence;juvenile animal;Laws;Learning;mature animal;Memory;Modeling;neural;Neuroanatomy;neurochemistry;neuromechanism;Neurons;Pharmaceutical Preparations;Pharmacological Treatment;Play;Predisposition;Prevalence;Procedures;Process;Psychopathology;Publishing;pup;Rattus;resilience;response;Role;Series;Sexual abuse;Stimulus;Stress;stress reactivity;stress resilience;Stressful Event;Structure;Techniques;Testing;traumatic event;treatment strategy;United States;War;young adult

PROJECT_TITLE: Susceptibility and Resilience to Adverse Childhood Experiences: A Role for Perineuronal Nets

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Microbiome;Precision Medicine;Women's Health Research

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative: A substantial proportion of women are not adherent to aromatase inhibitor (AI) therapy, primarily due to their experience of highly variable treatment- and/or disease- related symptoms. Symptoms and adherence, especially their impact on each other, have not been well-characterized temporally, nor have potential biologic mechanisms related to AI absorption, distribution, metabolism, and elimination (ADME). The purpose of the proposed F99/K00 training and research will utilize a biobehavioral, multi-omics approach to gain a deeper understanding of the temporal variability and interplay of symptoms, adherence, and omics to guide future interventions and their timing in women with breast cancer.

PI_NAMEs: MCCALL, MAURA KINDELAN (contact)

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: absorption;Adherence;Adjuvant;anastrozole;Aromatase Inhibitors;biobehavior;Biological;Biological Factors;Breast Cancer Prevention;cancer recurrence;career;Characteristics;Classification;Clinical;cohort;Complex;Diagnosis;Disease;Dose;Etiology;Exemestane;exosome;experience;Future;Genes;genomic variation;Genomics;Genotype;Germ Lines;Goals;gut microbiome;gut microbiota;Heritability;High Risk Woman;hormone receptor-positive;improved;inhibitor therapy;insight;Internet;Intervention;Letrozole;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;medication compliance;Metabolism;Methods;microbiome research;microbiota composition;Modeling;Molecular;multiple omics;Nature;Outcome;Pathway interactions;Patient Self-Report;Patient-Focused Outcomes;Patients;Pattern;personalized health care;Pharmaceutical Preparations;Phase;Phenotype;Population;post-doctoral training;Postdoctoral Fellow;Postmenopause;Precision Health;Recurrence;Regimen;Reporting;Research;Research Personnel;Risk;Role;Sampling;Severities;side effect;Source;standard of care;Subgroup;Survivors;symptom management;Symptoms;tailored health care;therapy development;Time;Toxic effect;Training;treatment planning;treatment response;tumor;Woman;Work

PROJECT_TITLE: A Multi-omics Approach to Examine Symptoms and Medication Adherence in Women with Breast Cancer


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Social Determinants of Health

ORG_CITY: ONDO

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: UNIVERSITY OF MEDICAL SCIENCES, ONDO

PHR: Project narrative Increasing evidence associates exposure to environment toxicants such as heavy metals to negative neurological consequences, particularly, perinatal exposure to heavy metals is increasingly linked to neurodevelopmental disorders. Our study aims to investigate morphological, behavioral, and molecular alterations caused by developmental exposure to heavy metals in relation to endpoints of autism spectrum disorders (ASD). Our proposal will provide novel translational information on the importance of inherent genetic differences and exogenous chemical perturbations of cellular processes as potential modifiers of metal-induced neurotoxicity and neurodevelopmental disorders such as ASD; thus, laying the groundwork for innovative therapeutic strategies against neurodevelopmental disorders.

PI_NAMEs: IJOMONE, OMAMUYOVWI MEASHACK (contact)

PROGRAM_OFFICER_NAME: HAYES, UNJA

PROJECT_TERMS: Affect;Animals;Applications Grants;autism onset;autism spectrum disorder;Award;Behavioral;behavioral impairment;biological adaptation to stress;Biomedical Research;Brain;brain dysfunction;Caenorhabditis elegans;career development;Career Mobility;Categories;Cell Physiology;Chemicals;Communication;Communities;contaminated water;Data;design;Development;developmental neurotoxicity;Disease;early childhood;early life exposure;economic implication;Environment;Environmental Pollutants;Environmental Risk Factor;Epidemiology;Etiology;experience;Exposure to;falls;Future;Gene Expression;General Population;Genes;Genetic;genetic analysis;Goals;Health;Heavy Metals;Hereditary Disease;Human;Human Genome;Impaired cognition;improved;Industrialization;innovation;interest;Knowledge;knowledge translation;lecturer;Life;life span;Link;loss of function mutation;Manganese;Manuscripts;Maps;Mentors;Mentorship;Metals;Methodology;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;Morphology;Mutation;Nerve Degeneration;Nervous System;Nervous System Disorder;neural network;Neurodevelopmental Deficit;Neurodevelopmental Disorder;Neurologic;Neurologic Deficit;neuron loss;neuroprotection;neurotoxic;neurotoxicity;new therapeutic target;Nickel;Nigeria;Nigerian;novel;Oils;Oxidative Stress;Pathogenesis;Pathway interactions;Pattern;Perinatal Exposure;Physicians;Policy Maker;Predisposition;prenatal;professor;programs;Reporting;Research;Research Activity;research and development;Research Personnel;Risk;risk variant;Role;senescence;Signal Transduction;skills;Social Interaction;Soil;Stress;Structure;Synapses;Technology;Testing;Therapeutic;Toxic Environmental Substances;toxicant;Toxicology;Training Programs;translational model;Translational Research;transmission process;Universities;Writing;young adult

PROJECT_TITLE: Developmental neurotoxicity and autism spectrum disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Pediatric;Prevention;Rehabilitation;Serious Mental Illness;Sleep Research;Suicide;Suicide Prevention;Violence Research;Youth Violence

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it addresses the urgent need to reduce suicide rates among teens. Given the limited success of prior treatment trials and emerging research demonstrating a strong link between insomnia and suicidality, pilot effectiveness research examining the impact of reducing insomnia symptom severity on outcomes of suicide-focused treatments is a critical next step in adolescent suicide prevention research. This will be the first study that we know of to examine the feasibility and preliminary effectiveness of augmenting a suicide-focused treatment (Dialectical Behavior Therapy) with an evidence-based treatment protocol for insomnia (a digital version of Cognitive Behavioral Therapy for Insomnia).

PI_NAMEs: BERK, MICHELE STACY (contact);MANBER, RACHEL

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TERMS: 14 year old;Address;Adolescent;Adult;Age;Behavior;Behavior Therapy;Cause of Death;Cognitive Therapy;Comorbid Insomnia;depressive symptoms;Detection;Diagnostic;Dialectical behavior therapy;digital;digital treatment;Disease remission;Dropout;Effectiveness;effectiveness research;effectiveness trial;efficacious treatment;efficacy trial;evidence base;Evidence based treatment;feasibility trial;Feeling suicidal;Goals;high risk;improved;inclusion criteria;innovation;International;internet delivery;Intervention;Interview;Investigational Therapies;Link;Measures;Mediating;Mediator;National Institute of Mental Health;neglect;novel;novel strategies;Outcome;pilot trial;Prevention Research;Protocols documentation;Public Health;Randomized;reducing suicide;Reporting;Research;Risk Factors;Safety;Sampling;satisfaction;Self-Injurious Behavior;Severities;Signal Transduction;Sleep;sleep-focused interventions;Sleeplessness;Speed;standard care;Strategic Planning;success;suicidal;suicidal adolescent;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;Symptoms;Teenagers;therapy development;therapy outcome;Time;timeline;treatment duration;Treatment Protocols;treatment trial;United States;uptake;Work;Youth

PROJECT_TITLE: Combined Dialectical Behavior Therapy and Digital Cognitive Behavioral Therapy for Insomnia for Adolescents at High Risk for Suicide: A Pilot RCT

STUDY_SECTION: EMHI

STUDY_SECTION_NAME: Effectiveness of Mental Health Interventions Study Section[EMHI]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Visual Snow Syndrome is a poorly understood neurological condition involving persistent perception of visual specks or 'snow' that can be debilitating and interfere with daily life. This project seeks to determine how both visual perception and processing within the brain are altered in Visual Snow Syndrome. A better understanding of how people with Visual Snow Syndrome see and process visual stimuli is necessary to develop potential treatments and assistive technologies that could improve quality of life.

PI_NAMEs: MONTOYA, SAMANTHA A (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Address;Afterimage;Automobile Driving;Behavioral;Brain;career;Clinical;common symptom;comorbidity;comparison control;Contrast Sensitivity;Detection;Diagnosis;Disease;effective therapy;Environment;Exclusion;Exhibits;experience;experimental study;Frequencies;Functional Magnetic Resonance Imaging;Future;Human;Image;improved;Knowledge;Life;luminance;Magnetic Resonance;Measurement;Measures;Migraine;neural;neuroimaging;Neurologic;neuromechanism;novel;Participant;Patients;Perception;Performance;Persons;Pharmacologic Substance;Photic Stimulation;Photophobia;Prevalence;Process;Psychophysics;Qualifying;Quality of life;Reading;Research;Resolution;response;Science;Self-Help Devices;Sensory;Series;Signal Transduction;Stimulus;Symptoms;Syndrome;Technology;Television;Testing;Time;Tinnitus;Training;Vision;Vision Disorders;vision science;Visual;Visual Fields;Visual Perception;visual performance;visual processing;Visual Psychophysics;visual stimulus;Visual System;Work

PROJECT_TITLE: Visual Perception in Visual Snow Syndrome


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Cost Effectiveness Research;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: ATLANTA

ORG_DEPT: UROLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE Our center uniquely combines patient and specimen resources from a breadth of health care settings in/near Atlanta (Grady Memorial Hospital in Atlanta, the Atlanta VAMC in Decatur, St. Joseph's Hospital in Sandy Springs, and Emory University Hospital in Atlanta) together with the University of Alabama in Birmingham and the University of Texas -Southwestern Medical Center in Dallas and partners with laboratories from throughout the U.S. to improve detection of prostate cancer. We also seek to determine which of these cancers should be treated and which ones can be safely managed without treatment.

PI_NAMEs: SANDA, MARTIN G. (contact)

PROGRAM_OFFICER_NAME: KOHAAR, INDU

PROJECT_TERMS: Address;Adherence;advanced prostate cancer;African American;African American population;Alabama;Algorithms;American;Artificial Intelligence;Biological Assay;Biological Markers;biomarker discovery;Biomedical Engineering;Biopsy;Blinded;Blood Tests;cancer biomarkers;cancer care;cancer imaging;Cancer Intervention and Surveillance Modeling Network;career development;case control;Clinical;Clinical Data;clinical research site;Clinical Treatment;clinically significant;cohort;Collaborations;cost effectiveness;cost-effectiveness evaluation;Country;Data;deep learning;design;Detection;detection method;Diagnosis;Diagnostic;digital health;Disease;Early Detection Research Network;Enrollment;Enzyme-Linked Immunosorbent Assay;Faculty;FOLH1 gene;Fostering;Funding;Genes;Genetic Transcription;Goals;Health;health care settings;Hospitals;Image;Imaging Techniques;Impact evaluation;improved;indexing;Indolent;Industry;innovation;Investigation;KLK3 gene;Laboratories;Leadership;Magnetic Resonance Imaging;Malignant neoplasm of prostate;Malignant Neoplasms;Measurement;Medical center;men;Michigan;Nested Case-Control Study;Nomograms;Oncology;overtreatment;Patients;Performance;PET/CT scan;Phase;phase IV trial;Positron-Emission Tomography;predictive modeling;Progress Reports;prospective;Prostate;prostate biopsy;prostate cancer risk;Publications;Publishing;radiotracer;Research Design;Research Personnel;Resources;RNA;Screening for Prostate Cancer;Serum;Specimen;Techniques;Testing;Texas;Tissues;TMPRSS2 gene;transcriptome;Translating;United States National Institutes of Health;Universities;University Hospitals;urinary;Urine;Validation;validation studies;Work

PROJECT_TITLE: Prostate Cancer Biomarker and Imaging Validation Alliance: Emory University, University of Alabama Birmingham, and University of Texas Southwestern


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: Columbus

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative This project focuses on mentoring of junior clinician scientists who will be taken to that cutting edge where successful academic careers begin. Mentoring will be done through several funded and developmental projects that will teach not only how to conduct research but will also introduce mentees to the processes of commercialization of new discoveries.

PI_NAMEs: BOYER, EDWARD W (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Accelerometer;Acute Pain;Address;Adherence;Adopted;Adult;Affect;Affective;Anti-Retroviral Agents;antiretroviral therapy;Area;Artificial Intelligence;Award;Behavior;Behavior Therapy;Behavioral;Biosensing Techniques;Biosensor;Brain;Cannabis;Capital;career;career development;Caring;Cellular Phone;cohort;Collection;commercialization;Communicable Diseases;comorbidity;computer scientist;Contracts;COVID-19;COVID-19 diagnosis;Data;Data Collection;Dedications;design;detector;Development;Devices;Diagnosis;digital divide;digital phenotyping;digital technology;Discipline;Discrimination;Drug abuse;Drug usage;Educational process of instructing;Electrical Engineering;Electronics;Exhalation;experience;Funding;General Population;Goals;Health;Health behavior;health care availability;health care disparity;health care economics;health data;Health Technology;Healthcare;HIV;Human;Imagery;improved;Individual;Ingestion;Inhalation;innovation;Institution;Institutional Review Boards;Intellectual Property;Interdisciplinary Study;interest;Intervention;Investigation;irritation;Learning;Life;Machine Learning;magnetic field;Malaysia;Maps;Measures;Medical;medication compliance;Mental Depression;Mentors;Methods;mHealth;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;Minority;Mission;mobile computing;Music;nasal swab;National Institute of Drug Abuse;neurotransmission;next generation;Nociception;novel;opiate tolerance;Opioid;opioid use;Pathway interactions;Patient Care;Patients;Pattern;Penetrance;personal protective equipment;Persons;Pharmaceutical Preparations;pill;Play;Population;Populations at Risk;Principal Investigator;Process;programs;Property Rights;Research;Research Personnel;Research Project Grants;response;Rewards;Risk Behaviors;Role;SARS-CoV-2 infection;Scholarship;Scientist;Self Management;skills;social stigma;socioeconomics;Source;substance abuse prevention;Substance abuse problem;substance abuse treatment;Substance Use Disorder;success;Techniques;Technology;Telephone;Temperature;Testing;Text Messaging;theories;therapy adherence;therapy development;Time;United States National Institutes of Health;Virus Diseases;wearable sensor technology;Woman;Wrist

PROJECT_TITLE: Mentoring in Advanced mHealth Technologies and Machine Learning for HIV/Drug Abuse Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: Narrative Asian American and Pacific Islander (AAPI) populations are an extremely diverse group, representing 30 different countries (e.g., Filipino, Chinese, Indian, Vietnamese, Japanese, etc), and in the United States have different immigration histories, cultural traditions, and medical risks, and live in segregated neighborhoods. AAPI mother and infant populations have been understudied, but without detailed knowledge of these populations, mothers and infants will receive suboptimal care during childbirth, which may result in unnecessary mortality or lifelong morbidity. We propose to address this gap, setting the stage for reducing disparities among AAPI mothers and infants.

PI_NAMEs: MAIN, ELLIOTT K;PROFIT, JOCHEN  (contact)

PROGRAM_OFFICER_NAME: CHAKHTOURA, NAHIDA ABDO

PROJECT_TERMS: Accounting;Acculturation;Address;Affect;American;Area;Asian;Asian Americans;Attention;Benchmarking;Biological;Birth;Birth Rate;Black Populations;breastfed newborn;California;care delivery;care outcomes;Caring;Cesarean section;Cessation of life;Childbirth;Chinese;Clinical;Collaborations;Communities;comparative;Country;Data;data resource;Data Set;Data Sources;design;Disparity;disparity reduction;Epidemiology;Episiotomy;Equity;ethnic disparity;Ethnic Origin;Ethnic Population;experience;Filipino;Future;Geography;Health;health care disparity;Heterogeneity;high risk population;Hispanic Populations;hospital care;hospital performance;Hospitalization;Hospitals;Human Milk;Immigration;improved;Individual;Infant;Infant Care;Infant Mortality;Infrastructure;innovation;insight;Interview;Japanese;Joints;Knowledge;Laceration;Link;Literature;Maternity Hospitals;Measures;Medical;member;Methods;Monitor;Morbidity - disease rate;mortality;Mothers;multidisciplinary;National Health Policy;Neighborhoods;Neonatal Intensive Care Units;Newborn Infant;Nosocomial Infections;Not Hispanic or Latino;Nulliparity;Outcome;Pacific Islander;Parents;Patients;Performance;Perinatal;Persons;Policies;policy recommendation;Population;population based;Positioning Attribute;Process;Provider;quality improvement organization;Quality of Care;Race;racial disparity;racial population;Recording of previous events;Reporting;Research;Research Personnel;Risk;Risk Factors;Sampling;segregation;severe maternal morbidity;Small for Gestational Age Infant;social;social culture;sociodemographics;Socioeconomic Status;Structure;Subgroup;success;Surveys;Testing;Translating;United States;Variant;Very Low Birth Weight Infant;Vietnamese;Vulnerable Populations;Work

PROJECT_TITLE: Disparities in Processes and Outcomes of Care Across Asian/Pacific Islander Populations at Childbirth

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Networking and Information Technology R&D (NITRD);Precision Medicine;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

ORG_STATE: MA

PHR: PROJECT NARRATIVE While many cancer genomics studies have opened novel biological paradigms for tumor-intrinsic dysregulation resulting from treatment resistance and new translational impacts, the role of integrated somatic, germline, and immune systems toward treatment resistance has not been fully characterized in GU cancers. With Research Specialist Dr. Jihye Park's recent and ongoing contributions, our NCI funded research programs will continue to conduct systematic and comprehensive investigations of somatic, germline, and immune cell components that together drive cancer risk and selective response to existing and emerging therapies across GU cancers. Under Unit Director Dr. Eliezer Van Allen's leadership, this interdisciplinary and highly collaborative group will continue to drive these comprehensive clinical computational research programs by utilizing novel sequencing approaches and computational methods, and by sharing these discoveries with the broader community to synergize collaboration in the cancer genomics field. 1

PI_NAMEs: PARK, JIHYE  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: analytical tool;Androgen Antagonists;Automobile Driving;Biological;Biology;Bladder;cancer genomics;cancer immunotherapy;cancer risk;Cells;Cellular Structures;Chromatin;Clinical;cloud based;Collaborations;Communities;Computing Methodologies;Data;Development;Disease;Disease Resistance;drug development;drug discovery;Epigenetic Process;Evolution;experience;Face;Funding;Genetic Transcription;Germ Lines;Immune;Immune system;Immunotherapy;Intrinsic factor;Investigation;Kidney;Laboratories;Leadership;Malignant neoplasm of prostate;Malignant neoplasm of testis;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Methods;Modality;Molecular;Molecular Profiling;multidisciplinary;Multiomic Data;novel;novel therapeutics;patient oriented;patient stratification;Patients;Process;programs;Prostate;Research;Resistance;response;Role;Scientist;Solid Neoplasm;Specialist;synergism;System;Testis;Therapeutic;therapeutically effective;therapy resistant;Training;translational impact;Translations;treatment stratification;tumor;Urogenital Cancer;whole genome

PROJECT_TITLE: Molecular origins and evolution to treatment resistance in genitourinary cancers


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TEMPE

ORG_NAME: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Cognitive decline in Blacks is prevalent, consequential, and understudied. The older U.S. population is expected to increase dramatically by 2030, growing from 35 to 72 million, and becoming significantly more racially and ethnically diverse. The goal of this project is to explore innovative approaches to address variation in risk and protective factors contributing to cognitive decline in Blacks, which may ultimately reduce the risk of subsequent dementia and Alzheimer’s disease development in minority populations.

PI_NAMEs: BYRD, DEANNAH ROSHAE (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Address;Adult;Affect;African American population;aged;Aging;aging population;Alzheimer's Disease;Alzheimer's disease related dementia;Arizona;Baltimore;Behavior;Biological;Biological Factors;Biological Markers;Black American;Black Populations;Black race;Body Composition;Buffers;Cardiovascular Diseases;career;Cognition;Cognitive;Cognitive aging;cognitive change;cognitive function;coping;Data;Dementia;dementia risk;Development;Diabetes Mellitus;Doctor of Philosophy;Elderly;Environment;Epidemiology;epidemiology study;ethnic diversity;Event;experience;Genetic;Goals;Health;health disparity;high risk;Hypertension;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;International;Knowledge;Life;life span;Longitudinal Studies;Mediating;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Minority;Minority Groups;Not Hispanic or Latino;older adult;Older Population;Outcome;Pattern;perceived stress;Policies;Population;Prevalence;Process;processing speed;professor;programs;protective effect;protective factors;psychosocial;Psychosocial Factor;Psychosocial Stress;Public Health;racial diversity;Research;Research Personnel;Resources;Risk;Risk Factors;Risk Reduction;Sampling;Short-Term Memory;social;social engagement;Social Network;Social support;Societal Factors;Societies;Stress;Stress and Coping;theories;Training;Transact;Universities;Variant

PROJECT_TITLE: The Epidemiology of Cognitive Decline in African Americans: Identifying Risk and Protective Factors

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Contraception/Reproduction;Estrogen;Infertility;Ovarian Cancer;Pediatric;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Here, we will add the developmental, spatial, and temporal dimensions to enhance the healthy human ovary HuBMAP data to identify disease modalities and support regenerative medicine technologies for women with premature ovarian insufficiency. Folliculogenesis, the process of creating an egg and producing ovarian hormones, is greatly influenced by extracellular factors that are different across development and space and provides the ideal model to study how a functional unit is affected by its environment. The milestones here will add to the functionality of the HuBMAP ovary atlas, demonstrate the utility of these datasets, and develop pipelines and technologies for future regenerative technologies that may be developed for other HuBMAP tissues.

PI_NAMEs: LARONDA, MONICA M (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: 3-Dimensional;5 year old;Address;Adolescent;Adult;Affect;Age;analysis pipeline;Anatomy;Atlases;Atomic Force Microscopy;Biochemical;biocomputing;Biological;Biopsy;Body System;Cardiovascular Diseases;Cell Physiology;cell type;Cells;Childhood;Cognition Disorders;Collaborations;comorbidity;Cues;Cytoplasm;Data;Data Set;Development;Dimensions;Disease;ECM receptor;egg;Engineering;Environment;extracellular;Extracellular Matrix;Fertility;fertility improvement;folliculogenesis;Future;Genetic Transcription;Germ Cells;Goals;granulosa cell;Growth;Histologic;Hormone replacement therapy;Hormones;Human;Human BioMolecular Atlas Program;human induced pluripotent stem cells;Image;imaging facilities;Imaging technology;improved;Individual;induced pluripotent stem cell;insight;interstitial;interstitial cell;Life Expectancy;Longevity;Maps;Metastatic Malignant Neoplasm to the Ovary;Methods;Michigan;Modality;Modeling;Molecular Profiling;Multimodal Imaging;Multiomic Data;multiple omics;Neighborhoods;Nutrient;oocyte maturation;oocyte quality;Oocytes;Ooplasm;Output;Ovarian;Ovarian Follicle;Ovarian hormone;Ovarian tissue cryopreservation;Ovary;Patients;pediatric patients;Pennsylvania;Physicians;Population;Positioning Attribute;prepuberty;primary ovarian insufficiency;Process;Production;Progressive Disease;Proteins;Proteomics;Protocols documentation;Puberty;puberty transition;Publishing;Quality of life;Readability;receptor binding;reconstruction;regenerative;Regenerative Medicine;regenerative therapy;Resources;response;restoration;Reverse engineering;Safety;scaffold;single-cell RNA sequencing;Somatic Cell;Stromal Cells;Technology;technology validation;Three-Dimensional Imaging;Tissue atlas;Tissue Engineering;tissue mapping;Tissues;tool;Translating;Universities;Woman

PROJECT_TITLE: Reverse Engineering the Extracellular Neighborhood to Support the Functional Tissue Unit: A Use Case to Restore Ovarian Function


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Pediatric;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE The ability to visualize synapses in the brain of living individuals with cannabis use disorder (i.e., in vivo) has recently become possible with positron emission tomography (PET). We have shown that individuals diagnosed with cannabis use disorder have a lower number of synaptic vesicles, which correlates with worse memory. The goal of this study is to use brain imaging to determine whether lower synaptic vesicle density and memory in individuals with cannabis use disorder recovers when they stop using cannabis for at least 4 weeks.

PI_NAMEs: D'SOUZA, DEEPAK CYRIL (contact);RADHAKRISHNAN, RAJIV

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Abstinence;Adolescence;Adolescent;Adult;Age;Animals;Auditory;Awareness;Benefits and Risks;Binding;Brain;Brain imaging;Brain region;cannabinoid administration;Cannabinoids;Cannabis;Cannabis policy;Chronic;CNR1 gene;Cognition;Cognitive deficits;Data;density;Diagnosis;Drug usage;DSM-V;Electroencephalography;experience;Exposure to;Gender;Goals;gray matter;Hippocampus;Human;illicit drug use;Image;improved;in vivo;indexing;Individual;Insula of Reil;Legal;Ligands;Link;marijuana use;marijuana use disorder;marijuana user;Maze Learning;Measures;Medial;Medical;Memory;Methods;Molecular;Monitor;Morphology;Parahippocampal Gyrus;partial recovery;Participant;Performance;Persons;Pharmaceutical Preparations;Positron-Emission Tomography;Proteins;Psychiatry;Receptor Down-Regulation;receptor downregulation;Recovery;Recreation;Reporting;Research;Resolution;risk perception;Rodent;Scanning;sex as a biological variable;Societies;spatial memory;Specificity;stability testing;Structure;Synapses;Synaptic Vesicles;synthetic cannabinoid;Teenagers;Temporal Lobe;Testing;Tracer;verbal;Verbal Learning;Vertebral column;Visualization;Work;young adult

PROJECT_TITLE: Do hippocampal synaptic density deficits in cannabis use disorder improve following abstinence?

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Urologic Diseases

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Although PD-1/PD-L1 immune checkpoint blockade (ICB) therapy has achieved durable clinical responses in a subset of bladder cancer patients (15-25%), the majority of patients have not benefitted from this therapy. These studies will build off our preliminary discovery of a pre-treatment myeloid-associated gene signature predictive of ICB resistance in bladder cancer by creating an immune atlas of treatment-naïve bladder cancer tumor, peripheral blood, and urine, a resource that does not currently exist, and establishing an in vitro monocyte- macrophage culture system to define and modulate the precise biological pathways and myeloid subsets underlying ICB resistance. Combined, these proposed aims will elucidate innate immune pathway driven resistance to ICB therapy in bladder cancer, which can be used to identify critical predictive clinical biomarkers and inform new combinatorial treatment strategies.

PI_NAMEs: TRAN, MICHELLE ALYSSA (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Accounting;adaptive immune response;adaptive immunity;angiogenesis;anti-PD1 antibodies;Antigen Presentation;Atlases;Autologous;Biological;Bladder Neoplasm;Blood;Cancer Patient;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Cessation of life;chemokine;Clinical;clinical biomarkers;clinical predictors;Clinical Trials;Coculture Techniques;cohort;Coin;Colon Carcinoma;combinatorial;complement pathway;cytokine;Data;drug candidate;drug testing;Exclusion;exhaustion;experimental study;follow-up;Genes;genetic signature;Genetic Transcription;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Hypoxia;Immune;immune checkpoint blockade;immunoregulation;Immunotherapy;improved;In Vitro;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;inflammatory modulation;inhibitor;innate immune mechanisms;innate immune pathways;insight;Interleukin-1 beta;Link;Macrophage;Macrophage Colony-Stimulating Factor;Malignant Breast Neoplasm;Malignant neoplasm of urinary bladder;Malignant Neoplasms;marenostrin;Mediating;Mediator;Modeling;Molecular;monocyte;Myelogenous;Myeloid Cells;novel strategies;Outcome;Pathogenesis;Pathway interactions;patient subsets;Patients;PD-1/PD-L1;peripheral blood;Pharmacotherapy;Phenotype;Play;Population;predictive marker;predictive signature;Primary Neoplasm;Production;Proteins;Proteomics;Publishing;Research;Resistance;resistance gene;resistance mechanism;Resolution;Resources;response;restraint;Role;Shapes;Signal Transduction;single cell genomics;single cell technology;single-cell RNA sequencing;Specimen;System;T-Lymphocyte;Testing;tool;transcriptome sequencing;transcriptomics;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor progression;Tumor Promotion;United States;Urine;Work

PROJECT_TITLE: Dissecting innate immune mechanisms of resistance to checkpoint blockade therapy in bladder cancer


ORG_CITY: Aurora

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative The support for training of young scientists and clinicians for future careers in research is a fundamental part of the NIAMS mission. The broad scope of this training program in many areas of cutaneous biology and skin diseases, combined with a focus on regenerative medicine and stem cell biology, are also ideal for NIAMS support.

PI_NAMEs: ASGARI, MARYAM MANDANA;ROOP, DENNIS  (contact)

PROGRAM_OFFICER_NAME: VINCENT, ISAAH S

PROJECT_TITLE: Training in Translational Research of Skin Diseases


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_CITY: DAYTON

ORG_NAME: UNIVERSITY OF DAYTON

PHR: Project Narrative 3D imaging is an indispensable tool for understanding biological processes. Although impressive progress has been made in the development of 3D imaging, existing techniques suffer from tradeoffs in terms of their resolution, field-of-view, and speed. The objective of this project is to develop an acoustic-based 3D nano- imaging technology that attaches seamlessly to a conventional optical microscope and achieves high resolution, large field-of-view, and high speed, simultaneously.

PI_NAMEs: AGHA, IMAD  (contact);HUANG, TONY JUN

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TITLE: Three-Dimensional (3D) Acoustofluidic Scanning Nanoscope with Super Resolution and Large Field of View

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Disability Research;Dissemination and Implementation Research;Headaches;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Migraine;Neurosciences;Pain Research;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Public Health Impact: Finding effective, safe, tolerable treatments could transform the lives of 45 million Americans living with migraine, half of whom require bedrest for relief. This study evaluates the impact of a mind-body treatment on headache-related disability using an eHealth delivery format that increases access and availability to diverse populations. If effective, an easily accessible, standardized, non-drug, non-opioid treatment could be available to target the highly prevalent disease of migraine and its associated disability.

PI_NAMEs: WELLS, REBECCA ERWIN (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Acute;addiction;Address;Adult;Affect;Age;American;Analgesic Overuse Headaches;Anxiety;Area;Attention;Awareness;Bed rest;Behavior Therapy;behavioral clinical trial;Biometry;bodily sensation;Brain;career;chronic pain;Clinical;Clinical Trials;clinically significant;cognitive function;comparison group;Consolidated Framework for Implementation Research;cost;Data;design;disability;Disability Evaluation;disability impact;Disease;Dose;Education;efficacy evaluation;efficacy testing;eHealth;Electronics;emotion regulation;Evaluation;evidence base;experience;Feeling;flexibility;follow-up;Frequencies;Funding;Future;future implementation;Goals;Headache;Headache disability;Health;health disparity;health equity;Home;implementation intervention;implementation science;implementation study;implementation trial;improved;instructor;interest;Internal Medicine;internet delivery;Interoception;Intervention;Mediating;Meditation;Mental Depression;Mental Health;Methodology;Migraine;Migraine disability;migraine treatment;Mind-Body Intervention;mindfulness;mindfulness intervention;mindfulness-based stress reduction;Monitor;National Center for Complementary and Integrative Health;Nervous System Disorder;Nociception;non-drug;non-opioid analgesic;online intervention;Opioid;opioid use;Pain;pain catastrophizing;pandemic disease;Participant;Patient-Focused Outcomes;Patients;perceived stress;Persons;Pharmaceutical Preparations;Phase;Population Heterogeneity;post intervention;primary endpoint;primary outcome;programs;Public Health;Publishing;randomized, clinical trials;Recommendation;recruit;remote assessment;remote delivery;Reporting;Research;Research Personnel;response;Risk;Safety;Sampling;secondary outcome;Self Efficacy;side effect;Standardization;Stress;targeted treatment;Techniques;Technology;telehealth;Tension Headache;Thinking;Time

PROJECT_TITLE: Online TEAM Migraine: Online Techniques and Education Aimed to Manage Migraine


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: GAINESVILLE

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE  The treatment of solid tumors with immune checkpoint inhibitors is promising, yet understanding treatment resistance against brain malignancies is paramount. We have found a novel way to overcome treatment resistance to anti-PD-1 monotherapy by employing concomitant transfer of bone marrow-derived hematopoietic stem and progenitor cells (HSC) with PD-1 checkpoint inhibition in preclinical models of high grade glioma and medulloblastoma. The project goals are to dissect and understand treatment resistance to HSC + PD-1 therapy in subjects with non-curative treatment.

PI_NAMEs: FLORES, CATHERINE T (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adjuvant;Anatomy;anti-PD-1;anti-PD1 therapy;Antigens;Beds;beta Chain Antigen T Cell Receptor;Bone Marrow;Brain;Brain Neoplasms;cancer therapy;CD8-Positive T-Lymphocytes;Cell Physiology;Cell Therapy;Cells;checkpoint inhibition;clinical application;clinical development;Clinical Research;clinically relevant;combinatorial;Cross-Priming;cytotoxic;Data;Dendritic Cells;Development;Disease;Disease Progression;draining lymph node;effector T cell;Engraftment;experience;Extravasation;Family;Frequencies;Gene Expression Profile;Genetic;Glioblastoma;Glioma;Goals;Hematopoietic stem cells;Immune;immune activation;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;immunoregulation;Immunotherapeutic agent;Immunotherapy;Interferon Type II;Intracranial Neoplasms;Intravenous;Location;Lymphocyte;Maintenance;Malignant Glioma;Malignant neoplasm of brain;Malignant Neoplasms;Medulloblastoma;Methods;Modeling;molecular subtypes;monocyte;Mus;Neoadjuvant Therapy;novel;Outcome;Pathway interactions;Patients;PD-1 blockade;pharmacologic;Population;Pre-Clinical Model;prevent;programmed cell death ligand 1;programmed cell death protein 1;Proliferating;Publications;Publishing;Randomized;recruit;Recurrence;Refractory;Regulatory Pathway;Resistance;resistance mechanism;Science;Site;Solid Neoplasm;Suppressor-Effector T-Lymphocytes;T-Cell Activation;T-Lymphocyte;Therapeutic;therapy resistant;tool;Toxic effect;Transcend;Transforming Growth Factor beta;tumor;Tumor Antigens;tumor heterogeneity;Tumor Immunity;tumor microenvironment;Tumor-associated macrophages;Variant

PROJECT_TITLE: Hematopoietic stem cells overcome treatment resistance to PD-1 blockade against brain tumors

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Genetics;Lymphatic Research;Lymphedema

ORG_CITY: PALO ALTO

ORG_NAME: PALO ALTO VETERANS INSTIT FOR RESEARCH

PHR: PROJECT NARRATIVE Lymphedema is a chronic condition characterized by poor fluid drainage from the skin and has no approved drug therapies; the syndrome afflicts 200 million people globally including 15-50% of cancer survivors. The reduction in a protective molecule, called hypoxia-inducible factor (HIF)-2α, may be an important cause of this disfiguring disease. This project seeks to understand the role of HIF-2α in lymphedema development so that the disease may be better understood and new treatments developed.

PI_NAMEs: JIANG, XINGUO  (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Address;Affect;angiogenesis;Anti-Inflammatory Agents;Architecture;Binding;Biological Assay;Biology;Blood;Blood capillaries;Blood Vessels;Cancer Survivor;cell transformation;Cellular Metabolic Process;Characteristics;Chromatin;Chronic;Clinical;Clinical Trials;Collagen;comorbidity;Data;Deposition;Dermal;design;Development;Disease;Disease Pathway;Disease Progression;Drainage procedure;Endothelial Cells;Endothelium;Experimental Models;fatty acid oxidation;Functional disorder;gene network;Genes;Genetic Transcription;Genus Hippocampus;Glycolysis;Grant;Homeostasis;Hypoxia Inducible Factor;improved;in vivo evaluation;Inflammation;Inflammation Mediators;Inflammatory;Intercellular Fluid;Interferon Type II;Investments;Ketoprofen;Knock-out;Knowledge;Leukotriene B4;Lipids;Liquid substance;Lymphatic;lymphatic development;Lymphatic Diseases;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic malformations;lymphatic vasculature;lymphatic vessel;Lymphedema;Maps;Mediating;Medical;Mesenchymal;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metaplastic cell transformation;Mus;new therapeutic target;Non-Steroidal Anti-Inflammatory Agents;Organ failure;overexpression;Oxygen;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Pharmacotherapy;Phenotype;Play;promoter;Proteins;Publications;Reporting;Research Personnel;Role;Signal Transduction;Skin;skin biopsy;Structure;Syndrome;Testing;therapeutic development;Tissues;tool;transcription factor;Transforming Growth Factor beta;uptake;Vascular remodeling;Work

PROJECT_TITLE: A Critical Role for Hypoxia-Inducible Factors in Lymphedema

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Emerging Infectious Diseases;Hematology;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Sepsis

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The preterm neonatal gut microbiome is decimated by antibiotics leading to dysregulated immune responses, late-onset sepsis, and bacteremia from antibiotic resistant organisms. This proposal will identify microbial and host biomarkers predictive of bacteremic and culture-negative late-onset sepsis providing a microbiome- individualized framework for future antibiotic prescription in the neonatal intensive care unit to mitigate negative consequences. This Mentored Clinical Scientist Research Career Development Award K08 application describes the skills, training, and research plan that the PI, Dr. Drew Schwartz, will require over the next 5 years to become an independent physician-scientist studying the neonatal host gut microbiome interface.

PI_NAMEs: SCHWARTZ, DREW JOEL (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Achievement;Adult;adverse outcome;Advisory Committees;Age;Antibiotic Resistance;Antibiotic Therapy;Antibiotic-resistant organism;Antibiotics;antimicrobial;Award;Bacteremia;Binding;Bioinformatics;Biological Markers;Biological Response Modifiers;biomarker identification;Birth;Bladder;Cells;Cessation of life;Clinical;clinical heterogeneity;clinical training;clinically relevant;cohort;Colon;colon bacteria;colonization resistance;Combined Antibiotics;commensal bacteria;Communicable Diseases;Computer Models;Computing Methodologies;cytokine;Development;Disease;Doctor of Philosophy;Dose;dysbiosis;Educational workshop;Environment;Escherichia coli;Feces;Flow Cytometry;Funding;Future;Germ-Free;Gnotobiotic;Goals;Grant;gut microbiome;Gut Mucosa;Hospitalization;host microbiome;Human;humanized mouse;Immune;Immune response;Immunoglobulin A;Immunologic Markers;Immunologics;Incidence;Infant;Infection;Inflammatory;International;Invaded;K-Series Research Career Programs;late onset sepsis;Lead;Learning;Life;Lymphocyte;Medical;medical schools;Mentors;Mentorship;Metadata;microbial;microbial composition;microbiome;microbiome analysis;microbiome composition;microbiome sequencing;microbiota;Modeling;modifiable risk;mortality;mouse model;Mucosal Immune Responses;Mucous Membrane;Mus;Neonatal;neonatal human;neonatal infection;Neonatal Intensive Care Units;neonatal mice;neonate;novel;Organism;pathogen;Pathogen detection;pathogenic bacteria;Pediatric Hospitals;Pediatrics;Peripheral;peripheral blood;Physicians;predictive marker;predictive modeling;Predisposition;preterm newborn;prevent;pup;repository;Research;Research Personnel;resistance gene;resistome;Resources;responsible research conduct;Risk Assessment;Risk Factors;Scientist;septic patients;skills;stool sample;symposium;Technical Expertise;Testing;Training;Training Programs;Universities;Urinary tract infection;Uropathogenic E. coli;Washington;Writing

PROJECT_TITLE: Antibiotic disruption of the gut microbiome and immune response in neonatal late-onset sepsis

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Advisory Committee[MID]


NIH_SPENDING_CATS: Natural Products

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The chemical synthesis of bioactive molecules is a scientific area of fundamental importance to the discovery of new medicines. This proposal seeks to develop the synthetic logic (the design concepts) and the synthetic tools (the chemical reactions) to enable the efficient preparation of structurally complex, bioactive molecules. In doing so, this research will accelerate the discovery of new medicines and enable study and treatment of human disease.

PI_NAMEs: REISMAN, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TERMS: Academia;Acceleration;Address;Adopted;Alkenes;Area;Biological;Carbon;Carboxylic Acids;catalyst;chemical reaction;chemical synthesis;Chemicals;Chemistry;Complex;Coupling;design;Development;Diterpenes;graduate student;human disease;invention;Lead;Logic;Medicine;Methods;Natural Products;Organic Chemistry;Outcomes Research;Pharmaceutical Chemistry;Pharmacologic Substance;Postdoctoral Fellow;Preparation;programs;Reaction;Research;Research Personnel;small molecule;theories;tool;Training

PROJECT_TITLE: Chemical Synthesis of Chiral Bioactive Molecules

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: The goal of this project is to understand the functions of H1 linker histones, a major family of proteins involved in regulating the structure and activity of mammalian chromosomes. Linker histones are essential for normal embryonic/fetal development. Perturbations in the synthesis or functioning of linker histones contribute to human diseases including cancer.

PI_NAMEs: SKOULTCHI, ARTHUR I (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Address;Affect;ATAC-seq;Biochemical;Biology;C-terminal;Cell Cycle;Cell Proliferation;ChIP-seq;Chromatin;Chromatin Fiber;Chromosomes;Deposition;design;Development;DNA;DNA Polymerase II;Drosophila genus;Embryonic and Fetal Development;Engineering;epigenetic regulation;ES Cell Line;Essential Genes;Euchromatin;G1 Phase;Gene Expression Regulation;Gene Family;Genes;Genetic Transcription;Goals;Heterochromatin;Hi-C;Histone H3;Histones;human disease;In Vitro;in vivo;insight;Kinetics;Knowledge;Lysine;Malignant Neoplasms;Mammalian Chromosomes;Messenger RNA;Methods;Methylation;Mitosis;Modeling;Mouse Embryonic Stem Cells;Mus;mutant;Nucleosomes;organizational structure;Outcome;Phase Transition;Play;Post-Translational Protein Processing;promoter;Protein Family;Proteins;RNA;RNA Splicing;Role;S phase;Salivary Glands;stem cell survival;Structural Protein;Structure;Testing;Transcription Elongation;transcriptome sequencing;Variant

PROJECT_TITLE: Functions of Mammalian H1 Linker Histones in Gene Regulation and Chromatin Activity

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: Chicago

ORG_NAME: NORTHWESTERN UNIVERSITY

PHR: Project Narrative This proposal aims to develop a new clinical imaging modality, referred to as visible-light optical coherence tomography (vis-OCT), to improve the clinical care of glaucoma. The new vis-OCT clinical modality will offer the highest resolution and new functional imaging capabilities to grade the earliest glaucoma damages that are unable to be detected currently.

PI_NAMEs: SCHUMAN, JOEL S;ZHANG, HAO F (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;Adoption;Age;Algorithms;Anatomy;Angiography;Anterior;Area;arteriole;Biological Markers;Biological Sciences;Biomedical Engineering;Blood capillaries;Blood Vessels;Caring;Cells;Clinical;clinical care;clinical imaging;Clinical Management;clinical translation;Collaborations;Color;computerized data processing;Data;data acquisition;Dendrites;design;Detection;Diagnosis;Disease;Doppler Ultrasound;early detection biomarkers;Eye;Floor;Foundations;Functional Imaging;Glaucoma;Goals;healthy volunteer;Hemoglobin;Human;Image;image processing;imaging capabilities;imaging modality;Imaging technology;improved;Inner Plexiform Layer;Interdisciplinary Study;Lasers;machine learning method;Measurement;Measures;Mechanics;Medicine;Metabolic;metabolic imaging;meter;Methodology;Modality;Morphologic artifacts;Motion;neurotoxic;Ophthalmoscopes;Optical Coherence Tomography;Optical Tomography;Oxygen;Pathogenesis;Pathway interactions;Patients;Process;programs;Protocols documentation;Research;research clinical testing;Resolution;Retina;Retinal Ganglion Cells;retinal imaging;Rodent;Sampling;Scanning;Scientist;Structure;Synapses;System;Techniques;Technology;theories;Thick;Time;Tissues;tool;ultra high resolution;Ultrafine;Variant;venule;Visible Radiation;Visualization

PROJECT_TITLE: Clinical glaucoma management enabled by visible-light OCT

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Rehabilitation

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Depression and anxiety disorders rank in the top ten causes of years lived with disability, and our most effective psychological treatments produce long-lasting improvements for less than 50% of patients. The proposed study will assess brain and behavioral responses during decisions to approach versus avoid outcomes that may be rewarding or threatening. The primary aim of this work is to enhance our understanding of (a) how these brain and behavioral responses change as a result of divergent psychological treatment approaches, namely behavioral activation and exposure-based therapy and (b) which individuals are most likely to improve with which psychological treatment approach.

PI_NAMEs: AUPPERLE, ROBIN L (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Amygdaloid structure;Animals;Anxiety;Anxiety Disorders;anxiety symptoms;anxiety treatment;approach behavior;approach/avoidance behavior;Bayesian Analysis;Behavior;behavior prediction;Behavior Therapy;Behavioral;Behavioral Mechanisms;behavioral response;Biological Markers;Brain;Clinical;clinical decision-making;Cognitive;Cognitive Therapy;Collaborations;comorbidity;computational basis;computer framework;Computer Models;Conflict (Psychology);Corpus striatum structure;Cues;Decision Making;demographics;Depressive disorder;depressive symptoms;Development;Diagnosis;Diagnostic;Disease;Dorsal;efficacious treatment;Emotional;expectation;experience;Exposure to;Face;Freezing;Fright;Functional Magnetic Resonance Imaging;Goals;habituation;imaging study;improved;Individual;Intervention;Knowledge;Measures;Mental Depression;Mental Health;Modeling;Mood Disorders;Motivation;neural;neuromechanism;neuroregulation;Outcome;Participant;Patient Self-Report;Patients;personalized approach;Phase;predicting response;Process;psychologic;Psychological reinforcement;Psychotherapy;Randomized;recruit;Relapse;Reporting;Research Domain Criteria;response;Rewards;Role;Series;Severities;standard care;Supportive care;symptomatic improvement;symptomatology;Symptoms;Testing;theories;therapy outcome;Treatment Efficacy;Treatment outcome;treatment response;Uncertainty;Withdrawal;Work;years lived with disability

PROJECT_TITLE: An Approach-Avoidance, Computational Framework for Predicting Behavioral Therapy Outcome in Anxiety and Depression


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Narrative Infection of primary nasal epithelial cultures with human respiratory coronaviruses including SARS-CoV-2 (and its variants) and MERS-CoV and the common coronaviruses HCoV-NL63, -229E and -OC43 will be used to model the earliest site of infection and identify similarities and difference in replication, cytopathic effects and host response to these viruses that progress to different clinical severities. Cultures derived from individuals with risk polymorphisms in genes associated with COVID-19 will identify mechanisms underlying risk for disease. These studies will contribute to designing strategies to prevent or counteract infection with current coronaviruses and those that are likely to emerge in the future.

PI_NAMEs: COHEN, NOAM A;WEISS, SUSAN R (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;adaptive immune response;Address;Affect;Air;airway epithelium;alveolar type II cell;Amino Acid Sequence;anti-microbial peptide;Anti-viral Response;biobank;Biological;Biology;Cell Line;Cell membrane;cell type;Cells;China;Clinical;cold temperature;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 pandemic;COVID-19 risk;cytokine;Cytopathology;Cytoplasm;Data;design;Disease;Disease Outbreaks;disorder risk;Endosomes;Epithelial Cells;Epithelium;experience;Functional disorder;Future;Genes;Genetic Polymorphism;Genetic Transcription;Genome;genome wide association study;genomic locus;Genotype;Human;human coronavirus;Immune response;Individual;Infection;Kinetics;Leucine Zippers;Link;Liquid substance;Lung;Lung infections;Middle East Respiratory Syndrome;Middle East Respiratory Syndrome Coronavirus;Modeling;Nasal Epithelium;Nitric Oxide;Nose;novel;Outcome;Pathogenicity;Pathway interactions;Pattern;Phenotype;Pneumonia;Positioning Attribute;prevent;Production;Productivity;Prophylactic treatment;Protein Isoforms;Proteins;Reporting;Resistance;Resources;respiratory;response;Ribonucleases;Risk;risk variant;Role;Route;SARS coronavirus;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;Scheme;sensor;Severities;Severity of illness;single-cell RNA sequencing;Site;Structure;Temperature;Testing;Therapeutic;TMPRSS2 gene;transcription factor;Upper Respiratory Infections;Upper respiratory tract;Variant;Viral;viral RNA;Virus;Virus Replication;Virus Shedding;Work

PROJECT_TITLE: Human coronavirus infection of the nasal epithelium

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed work aims to understand the cellular and circuit contributions to persistent neural activity, thought to be the neural basis of working memory and a building block of many forms of cognition. Deﬁcits in these functions are evident in Parkinson's disease, Alzheimers, schizophrenia, and a number of other brain diseases. Being able to repair or replace the mechanisms of persistent activity would be of signiﬁcant clinical relevance to this large set of human health challenges.

PI_NAMEs: HUK, ALEXANDER C (contact);PILLOW, JONATHAN WILLIAM

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Algorithms;Alzheimer's Disease;Animals;Architecture;Area;Behavior;Behavioral Paradigm;Biological;Biological Models;Brain;Brain Diseases;Brain region;Calcium;Callithrix;cell type;Chronic;clinically relevant;Code;Cognition;cognitive neuroscience;Complex;Computer Models;Data;Data Set;data-driven model;density;Development;Disease;Electrodes;Electrophysiology (science);Exhibits;experimental study;extracellular;FarGo;flexibility;foot;Genetic;Health;Human;Image;Individual;insight;Knowledge;large scale data;Link;Macaca;Maintenance;Maps;Measurement;Measures;Memory;Modeling;Modernization;Motor;Motor Activity;motor behavior;network models;neural;neural circuit;neuronal circuitry;Neurons;neurophysiology;Neurophysiology - biologic function;nonhuman primate;novel;oculomotor;Output;Parietal;Parietal Lobe;Parkinson Disease;Performance;Primates;Recurrence;repaired;Resolution;response;Rodent;Role;Saccades;Schizophrenia;Sensory;sensory input;Short-Term Memory;Signal Transduction;Specificity;Statistical Data Interpretation;Statistical Models;Techniques;Testing;Thalamic structure;theories;Time;tool;Training;two-photon;Visual;Work

PROJECT_TITLE: Mechanisms of persistent neural activity