NIH_SPENDING_CATS: Chronic Pain;Complementary and Integrative Health;Dental, Oral, and Craniofacial Disease;Pain Research;Rehabilitation

PROJECT_TERMS: 3D ultrasound;Acute;Affect;Anatomy;Anti-Inflammatory Agents;Antigens;Anus;Area;Back;Body System;Carrageenan;Cell Physiology;Cells;Chronic;Connective Tissue;Dinoprostone;Gene Expression;Genes;healing;Homeostasis;Hour;Immune;Inflammation;Inflammation Mediators;Inflammatory;inflammatory marker;Injections;intercellular communication;Journals;Lesion;Ligands;Limb structure;lipidomics;Lipids;Macrophage;Manuscripts;Mediator;migration;Modeling;Molecular;Movement;Mus;Musculoskeletal Pain;Neck;neutrophil;Pathway interactions;Patients;Pharmaceutical Preparations;Physical therapy;Population;Production;Productivity;Prostaglandin D2;Public Health;Publishing;Quality of life;receptor;recruit;reduce symptoms;Resolution;Rodent;side effect;single-cell RNA sequencing;Stretching;Tai Ji;Tissue Preservation;Tissues;Yoga

PROJECT_TITLE: Exploring the effect of stretching in the resolution of Connective tissue inflammation


ACTIVITY: ZIA

ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Nutrition

PI_NAMEs: BALLA, TAMAS  (contact)

PROJECT_TERMS: 1-Phosphatidylinositol 4-Kinase;Acute;Affect;amphiphysin;anti-microbial drug;Apoptosis;Binding;Biochemical Process;biophysical properties;Biosensor;Calcium Signaling;Cell Differentiation process;Cell membrane;cell motility;Cell Nucleus;Cell Physiology;Cell Surface Receptors;Cells;Cellular Membrane;Cellular Metabolic Process;cellular targeting;Chronic;Collaborations;Complex;Cytoplasm;density;design;Diabetes Mellitus;Diglycerides;Disease;Dynamin;Elements;Endoplasmic Reticulum;Engineering;Ensure;Environment;Enzymes;Equilibrium;Eukaryotic Cell;Event;experimental study;Family;Fatty acid glycerol esters;Fatty Acids;fighting;Focus Groups;Genes;Growth Factor;GTP-Binding Proteins;Hormones;human disease;Hydrolysis;In Vitro;India;Individual;information processing;inhibitor;Intercept;Interphase Cell;Ion Channel;late endosome;Lecithin;Life Cycle Stages;Lip structure;lipid metabolism;Lipids;Lipodystrophy;Lysosomes;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;Membrane Lipids;Membrane Transport Proteins;Metabolic;Metabolism;Minor;Mitochondria;mitochondrial membrane;Molecular;Morphology;Names;Neurodegenerative Disorders;Neurotransmitters;Nuclear;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Matrix;Nuclear Outer Membrane;Obesity;Oleic Acids;Organelles;Organism;pathogen;Pathway interactions;Phosphatidic Acid;Phosphatidylcholine Biosynthesis;phosphatidylinositol 4-phosphate;Phosphatidylinositol Phosphates;Phosphatidylinositol Transfer Protein;Phosphatidylinositols;Phosphatidylserines;Phospholipids;Process;Production;Proliferating;protein complex;Protein Isoforms;Protein Kinase;Proteins;Quality Control;receptor;reconstitution;Recovery;recruit;Regulation;Reporting;Research;response;Reticulum;RNA Splicing;Role;Series;Signal Transduction;Signal Transduction Pathway;Signaling Protein;Specificity;Surface;Tertiary Protein Structure;tool;trafficking;transmission process;Triglycerides;Virus

PROJECT_TITLE: Phosphoinositide-calcium Signaling In Cell Regulation


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Batten Disease;Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

PI_NAMEs: MUKHERJEE, ANIL B (contact)

PROJECT_TERMS: Ablation;Acetylcysteine;Acyltransferase;Adaptor Signaling Protein;Affect;age related;Alzheimer's Disease;Astrocytes;Autophagocytosis;Autophagosome;Autopsy;bench to bedside;Biochemical;Biological;Birth;blood-brain barrier crossing;Brain;brain tissue;Calcium;Cathepsins;Cause of Death;Cell membrane;Cell Nucleus;Cells;Ceroid;Child;Childhood;clinical investigation;Clinical Trials;CLN1 gene;CLN10 gene;CLN3 gene;curative treatments;Cystagon;Cysteamine;cytokine;Cytoplasm;Defect;Development;developmental genetics;Disease;effective therapy;Endoplasmic Reticulum;enzyme activity;Enzymes;extend lifespan;Fibroblasts;Functional disorder;functional mimics;Genes;Goals;Homeostasis;Human;Hydrolase;Hydroxylamine;Impairment;in vivo evaluation;infancy;Infantile neuronal ceroid lipofuscinosis;Inflammation;Inflammatory;insight;Investigation;ITPR1 gene;juvenile neuronal ceroid lipofuscinosis;Knockout Mice;Laboratories;Laboratory Research;Laboratory Study;late endosome;life span;Link;Location;lysosomal proteins;Lysosomal Storage Diseases;Lysosomes;Mediating;Membrane;Microglia;MicroRNAs;mimetics;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;Mus;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;neuron loss;Neuronal Ceroid-Lipofuscinosis;Neurons;neuropathology;neuroprotection;neurotoxic;Neurotoxins;Nonsense Mutation;novel;palmitoylation;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Patients;pre-clinical;preclinical study;Preparation;prevent;progressive neurodegeneration;Proliferating;Protein Complex Subunit;Proteins;Proton Pump;Protons;Rare Diseases;Recycling;Reporting;Research;Role;Seizures;small molecule;Spielmeyer-Vogt Disease;Techniques;Therapeutic;thioesterase PPT1 gene product;trafficking;transcription factor;Transgenic Mice;Translational Research;vacuolar H+-ATPase;virtual;young adult

PROJECT_TITLE: Childhood Neurodegenerative Lysosomal Storage Disorders


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: SHI, YUN-BO  (contact)

PROJECT_TERMS: Adult;Affect;Age;Alleles;Amphibia;Animals;Binding;Biological Assay;Biological Metamorphosis;Biological Process;Cell Death;Cell Differentiation process;Cell Proliferation;Cells;ChIP-seq;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;Connective Tissue;Consumption;cost;Development;Developmental Process;Diploidy;DNA Double Strand Break;DNA Repair;DNA sequencing;Embryo;Embryonic Development;endonuclease;Engineering;Epithelial Cells;Epithelium;feeding;Gene Expression;gene function;Gene Mutation;Gene Transfer Techniques;Genes;Genetic study;Genetic Transcription;genome editing;genome-wide;Genotype;Germ Lines;Goals;Histone Acetylation;histone acetyltransferase;histone methylation;Histones;homologous recombination;Hormone Responsive;Hormones;In Vitro;in vivo;indexing;Individual;insertion/deletion mutation;Intestines;Knock-out;knockout animal;Knowledge;Ligands;Limb Development;Limb structure;model development;model organism;Modeling;Molecular;Muscle;mutant;Mutation;NCOA3 gene;Nonhomologous DNA End Joining;Organ;Organ Culture Techniques;Organism;Pathologic Processes;Pathway interactions;Phenotype;Point Mutation;Postembryonic;Process;promoter;Protein-Arginine N-Methyltransferase;Rana;receptor binding;receptor expression;receptor function;recruit;Reliability of Results;Reporting;Research;reverse genetics;Role;single-cell RNA sequencing;South African;Statistical Data Interpretation;Steroid Receptors;Structure;System;Tadpoles;Tail;Thyroid Function Tests;Thyroid Hormone Receptor;Thyroid Hormones;Time;tissue/cell culture;toad;tool;transcription activator-like effector nucleases;transcriptome sequencing;Tubular formation;Uterus;Vertebrates;Xenopus;xenopus development;Xenopus laevis;zygote

PROJECT_TITLE: Molecular mechanism of thyroid hormone receptor function during metamorphosis


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Hypertension;Immunotherapy;Neurosciences;Rare Diseases

PI_NAMEs: PACAK, KAREL  (contact)

PROJECT_TERMS: Adrenal Gland Neoplasms;Adrenal Medulla;Adult;Affect;Age;ATRX gene;Basic Science;Biochemical;Biological Markers;Blood Pressure;cancer cell;cancer initiation;Cardiac;Catecholamines;CD4 Positive T Lymphocytes;CD8B1 gene;CDC2 gene;Chemistry;Chest;Clinical;clinical application;clinical decision-making;clinical diagnosis;Clinical Management;Clinical Trials;cohort;Collaborations;comorbidity;Competence;Complex;Consensus;cost;Data;Detection;Development;Diabetes Mellitus;Diagnosis;Diagnostic;Disease;Disparity;driving force;Ecosystem;effective intervention;Endocrinologist;Epidemiology;Etiology;Event;Excision;experience;Familiarity;flexibility;fluorodeoxyglucose;Functional disorder;gastroenteropancreatic neuroendocrine tumor;Gene Expression Regulation;Genes;Genetic;genetic signature;genomic profiling;Genomics;Genotype;Germ Lines;Goals;Growth;Head and neck structure;Health Professional;high risk;Hypertensive Crisis;Hypotension;Hypoxia;Image;imaging modality;Immune;immune cell infiltrate;Immunogenomics;Immunohistochemistry;Immunologic Markers;Immunotherapy;improved;Inherited;insight;Institution;Interdisciplinary Study;International;Knowledge;Laboratories;Lesion;Life;Link;Location;Macrophage;Magnetic Resonance Imaging;Medical;Medical center;meetings;metabolomics;Metastatic Neoplasm to the Bone;Metastatic Pheochromocytoma;Methods;Microsatellite Instability;migration;Modality;Modeling;Molecular;Molecular Biology;monocyte;Morbidity - disease rate;mortality;Mutation;Natural Killer Cells;Neoplasm Metastasis;Neuroendocrine Tumors;Neuroendocrinology;Nonmetastatic;Operative Surgical Procedures;Organ;Outcome;Paraaortic;Paraganglioma;Participant;Pathogenesis;Pathogenicity;Pathway interactions;Patient Care;patient oriented;patient oriented research;Patients;pediatric patients;Pelvis;Performance;PET/CT scan;Pharmaceutical Preparations;Pheochromocytoma;Physicians;preference;Process;Professional Organizations;Prognosis;prognostic;Prognostic Marker;prognostication;programmed cell death ligand 1;Provider;Publishing;Radiation therapy;Recurrence;Regression Analysis;Regulatory T-Lymphocyte;Research Personnel;Risk Marker;Signal Pathway;Signal Transduction;small cell lung carcinoma;Spinal;Succinate Dehydrogenase;Succinates;symposium;Tachyarrhythmias;Technology;The Cancer Genome Atlas;transcriptomics;Translational Research;tumor;tumor behavior;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions;tumorigenesis;United States National Institutes of Health;Up-Regulation;Variant;Vertebral column

PROJECT_TITLE: Diagnosis, Pathophysiology And Molecular Biology of Pheochromocytoma and Paraganglioma


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Contraception/Reproduction;Infertility;Intellectual and Developmental Disabilities (IDD);Neurosciences;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

PI_NAMEs: YEUNG, EDWINA  (contact)

PROJECT_TERMS: Address;advanced maternal age;Affect;Age;Age Months;Age Years;Archives;Assessment tool;Assisted Reproductive Technology;Attention;Bioethics;Biological Markers;Birth;Blindness;Blood;Blood specimen;Cerebral Palsy;Characteristics;Child;Child Development;Child Health;Childhood;Chronology;Clinical;Cognition;cohort;Conceptions;Congenital Abnormality;Consent;Couples;Data;Databases;deafness;Decision Making;design;Development;Developmental Disabilities;Diabetes Mellitus;Diagnosis;Early Intervention;Education;Enrollment;Environmental Exposure;feeding;Fetal Growth Retardation;First Births;Frequencies;Goals;Growth;Growth and Development function;Head circumference;Health;Health Insurance;Health Professional;health record;Health Services Accessibility;Hearing;high risk infant;High-Risk Pregnancy;Human;Hypertension;Impairment;improved;Incidence;infancy;Infant;infant outcome;infertility treatment;Information Systems;instrument;Insurance Coverage;intervention program;Investigation;Journals;Laboratories;Language;Left;Length;Link;Live Birth;Longitudinal Studies;Medical History;Mental Retardation;Minor;Monitor;Mothers;Motor;Motor Skills;Multiple Pregnancy;Neonatal Mortality;neonatal outcome;Neonatal Screening;neoplasm registry;neurodevelopment;Neurodevelopmental Impairment;New York;New York City;novel;Obesity;obesity treatment;Occupations;older women;Outcome;Ovulation;Parents;Participant;Pattern;Perception;Perinatal;Pharmaceutical Preparations;Physicians;Population;population based;Pregnancy;Premature Birth;Procedures;psychosocial;Publications;Publishing;Quadruplet Multiple Birth;Questionnaires;Recording of previous events;Records;recruit;Reporting;reproductive;residence;Residual state;Risk;Sampling;Schedule;School-Age Population;screening;skills;Social Development;Societies;Socioeconomic Factors;Special Supplemental Nutrition Program for Women, Infants, and Children;Spottings;Standardization;stillbirth;Subgroup;Technology;Testing;Time;time-to-pregnancy;treatment and outcome;Treatment Efficacy;Triplet Multiple Birth;Twin Multiple Birth;Twin Studies;United States;virtual;Vision;Weight;Woman

PROJECT_TITLE: Infertility Treatment, Child Growth and Development Through Age Three Years


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PROJECT_TERMS: Active Biological Transport;Adult;adult stem cell;Affect;Amino Acid Transporter;Amino Acids;Apoptosis;Architecture;Basal lamina;base;Biological Metamorphosis;Birth;Cell Count;Cell Culture Techniques;Cell Death;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Proliferation;cell type;Cells;Cessation of life;ChIP-seq;cofactor;Compensation;Complement;conditional knockout;Connective Tissue;Defect;Development;Electron Microscopy;Embryo;Ensure;Enterobacteria phage P1 Cre recombinase;Enteroendocrine Cell;Enzymes;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Exhibits;Extracellular Matrix;Food Processing;Genes;Genetic Transcription;Goals;Goblet Cells;Homeostasis;hormonal signals;hormone regulation;Hormones;Immunohistochemistry;in vivo;Individual;insulinoma associated 1;intestinal crypt;intestinal epithelium;intestinal homeostasis;intestinal maturation;Intestines;knock-down;Knock-out;knockout animal;Knockout Mice;larval control;Life;Ligands;Light;LoxP-flanked allele;Maintenance;Mammals;Mediating;Messenger RNA;Metabolic Diseases;Metabolism;Molecular;Molecular Analysis;mouse model;mouse Neurog3 protein;Mus;Muscle;Natural regeneration;NCOA3 gene;neonatal period;nutrient absorption;Organ;Organ Culture Techniques;organ repair;Paneth Cells;Pathway Analysis;Pathway interactions;Phenotype;Physiological;Physiology;Plasma;Play;Postembryonic;Primary Cell Cultures;Process;Proliferating;promoter;Property;protein expression;Protein-Arginine N-Methyltransferase;Rana;recruit;Regulation;response;Role;Secretory Cell;Secretory Vesicles;Signal Transduction;single-cell RNA sequencing;Small Intestines;South African;Specific qualifier value;Stem Cell Development;stem cell division;stem cell niche;stem cells;Structure;System;Tadpoles;Tamoxifen;Technology;Thyroid Hormones;Time;tissue regeneration;tissue repair;Tissues;toad;transcription factor;transcriptome sequencing;Up-Regulation;Vertebrates;villin;Villus;Xenopus;Xenopus laevis

PROJECT_TITLE: Regulation of stem cell development during tissue remodeling


NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infant Mortality;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: 7 year old;Address;African American population;Archives;Asian;Behavior;Birth;Blood specimen;Cardiovascular Diseases;cardiovascular disorder risk;Cause of Death;Cessation of life;Characteristics;Child;clinical center;Data;demographics;disorder risk;Enrollment;Epidemiology;Ethnic Origin;European;Event;follow-up;Gestational Diabetes;gestational weight gain;Goals;Gravid;Health;health record;hemodynamics;Hispanic;Hormones;insight;Interview;Kidney Diseases;Link;Malignant Neoplasms;Maternal Mortality;Maternal Physiology;Medical History;Metabolism;Microfilm;mortality;neonatal outcome;novel;Participant;Perinatal;perinatal complications;Perinatal mortality demographics;Placenta;Population;Postpartum Hemorrhage;Pre-Eclampsia;Pregnancy;Pregnancy Complications;pregnancy health;Pregnancy loss;Premature Birth;Prospective, cohort study;Race;Records;Research;Series;Socioeconomic Status;Stress;success;Universities;Woman

PROJECT_TITLE: Pregnancy and perinatal complications and mortality: Collaborative Perinatal Project mortality linkage study


NIH_SPENDING_CATS: Genetics

PI_NAMEs: LORSCH, JON  (contact)

PROJECT_TERMS: 5' Untranslated Regions;7-methylguanosine;Anticodon;Base Pairing;Binding;Binding Sites;Biochemistry;Biological Models;C-terminal;Codon Nucleotides;Collaborations;Complex;Dissociation;eIF-4B;eukaryotic initiation factor-5B;Event;Gene Expression;Gene Expression Regulation;genetic approach;Goals;GTP Binding;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Initiator Codon;Initiator tRNA;inorganic phosphate;Manuscripts;Mediating;Messenger RNA;Molecular;Molecular Conformation;molecular mechanics;Monitor;Movement;National Institute of Child Health and Human Development;Organism;Peptide Initiation Factors;Phase;Positioning Attribute;Process;Productivity;Protein Biosynthesis;Proteins;Publishing;recruit;Research;Ribosomes;RNA Cap-Binding Proteins;RNA Helicase;RNA-Binding Proteins;Saccharomyces cerevisiae;Scaffolding Protein;Scanning;Site;structural biology;Structure;Tail;transcriptome;Transfer RNA;Translation Initiation;Yeasts

PROJECT_TITLE: Elucidating the Molecular Mechanics of Eukaryotic Translation Initiation and Its Control


PROJECT_TERMS: 8 year old;Age;Anthropometry;arterial stiffness;Assisted Reproductive Technology;Biolectric Impedance;Biological;Birth;Birth Certificates;Blood;Blood Pressure;Body fat;cardiometabolic risk;cardiometabolism;cell growth regulation;Cell Physiology;Child;Child Health;Childhood;Clinic Visits;Clomiphene Citrate;cognitive development;cohort;Collection;Community Health;Data Collection;Data Coordinating Center;data management;dehydroepiandrosterone;Development;DNA Methylation;DNA Sequence;Epigenetic Process;European;falls;First Births;follow-up;Follow-Up Studies;Goals;Gonadotropins;Growth;Growth and Development function;Health;health difference;Hypertension;Infant Development;Infertility study;infertility treatment;Injectable;Link;Measurement;Measures;Metabolism;Methylation;middle childhood;New York;Obesity;Outcome;Ovulation;Paper;Parents;Participant;Pharmaceutical Preparations;Phase;Physiologic pulse;Protocols documentation;Public Health;Publishing;Pulmonary Inflammation;Research;Risk Factors;Saliva;Sampling;Scientist;screening program;Social Development;study population;Techniques;Technology;United States;Urine;web site

PROJECT_TITLE: Upstate KIDS Follow-Up Study


ACTIVITY: ZID

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Infertility;Orphan Drug;Pediatric;Rare Diseases;Women's Health Research

PI_NAMEs: GORDON, CATHERINE  (contact)

PROJECT_TERMS: Address;Adolescent;Agreement;Area;Basic Science;Child;Childhood;Clinical;clinical center;Clinical Research;Clinical Trials;Collaborations;Cooperative Research and Development Agreement;Creativeness;developmental disease;Developmental Endocrinology;Device or Instrument Development;Devices;Discipline;Disease;drug development;Environment;fertility preservation;Fostering;Genetic;half protocol;Health;Human;Human Development;image translation;improved;Industry;Infertility;Institution;Intramural Research;Intramural Research Program;Investigational Drugs;Knowledge;Mission;National Institute of Child Health and Human Development;Natural History;Neurosciences;Patient Care;Patient Participation;pediatric patients;Pediatrics;population health;Postbaccalaureate;Postdoctoral Fellow;Principal Investigator;programs;Protocols documentation;Rare Diseases;Reproductive Endocrinology;Reproductive Health;Research;Research Activity;Research Personnel;safe patient;Science;Services;summer internship;Technology Transfer;Training;United States National Institutes of Health;Women's Health

PROJECT_TITLE: NICHD Office of the Clinical Director


ACTIVITY: ZIE

NIH_SPENDING_CATS: Clinical Research;Health Services;Osteoporosis;Pediatric;Rare Diseases

PI_NAMEs: YANOVSKI, JACK A. (contact)

PROJECT_TERMS: Academic Training;Accreditation;Adolescent;Adrenal Gland Neoplasms;Ambulatory Care;Basic Science;Biotechnology;Bone Diseases;Child;Childhood;Clinic;Clinical;clinical care;clinical center;Clinical Research;Clinical Research Protocols;Clinical Skills;clinical training;Clinical Trials;Congenital adrenal hyperplasia;Consult;Cushing Syndrome;Dedications;design;Development;Diabetes Mellitus;Disease;Endocrine;Endocrinologist;Endocrinology;Ensure;experience;Exposure to;Fellowship;Fellowship Program;Grant;Growth and Development function;Health system;health training;Hospitals;Inborn Errors Lipid Metabolism;Inborn Errors of Metabolism;Institution;Laboratories;Laboratory Research;lipid disorder;Maryland;Medical center;Methods;Military Personnel;National Institute of Child Health and Human Development;Neuroendocrine Tumors;Obesity;Osteoporosis;Paper;Patients;Pituitary Neoplasms;Precocious Puberty;programs;Puberty;recruit;Research;research and development;Rotation;Services;Site;skills;statistics;Training;Training Programs;Translational Research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Pediatric Endocrinology Training Program


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Following the impending critical life event of childbirth, the purpose of my K supplement application is to request funding to continue supporting a full-time clinical research coordinator and a part-time biostatistician. The clinical research coordinator and biostatistician will assist me with literature review, managing IRB submissions, drafting research-related documentation, data management, data analysis, and supporting grant submissions.

PI_NAMEs: ZHEN-DUAN, JENNY  (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: Administrative Supplement;Adolescent;adverse childhood events;Alcohol consumption;alcohol misuse;Award;Biological;Birth;career;Caring;Child;Childbirth;Clinical Research;Data Analyses;Data Collection;data management;DNA Methylation;Documentation;Epigenetic Process;Event;Funding;Grant;Hair;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Infant;Institutional Review Boards;Latino;Life;Link;Manuscripts;Maternity leave;Mothers;National Institute on Alcohol Abuse and Alcoholism;Phase;Productivity;protective factors;Research;Review Literature;Risk Factors;Role;Saliva;Surveys;Time

PROJECT_TITLE: Administrative Supplement: Adverse childhood experiences and alcohol misuse in Latino adolescents


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Influenza is a virus that causes respiratory disease and circulates annually, despite a vaccine, and due to antigenic shifts, influenza can also cause pandemic disease. This project career development program will provide training that allows a veterinary physician-scientist to develop an independent research career aimed at understanding in detail how human antibody therapy can be used to treat and prevent disease and transmission. This knowledge work will inform vaccine design, and the antibodies studied and animal models developed will feed directly into translatable drug discovery.

PI_NAMEs: WOLTERS, RACHAEL  (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: aerosolized;Air;airway epithelium;Animal Model;animal model development;Animals;Anti-viral Agents;Antibodies;Antibody Therapy;Binding;Biological;Biological Assay;Biological Models;Biological Products;biophysical properties;Biophysics;Bronchopneumonia;career;career development;Cell Culture Techniques;cell immortalization;Cell Line;Cells;Cessation of life;Childhood;Clinical Trials;Complex;COVID-19 pandemic;Disease;drug candidate;Drug Delivery Systems;drug discovery;drug efficacy;drug testing;druggable target;efficacy evaluation;Elderly;Environment;Enzyme-Linked Immunosorbent Assay;experience;Family;FDA approved;Ferrets;follow-up;Glycoproteins;Goals;Health;Health Professional;Hemagglutinin;Human;human monoclonal antibodies;human tissue;Immune response;Immunoglobulin A;Immunoglobulin G;improved;In Vitro;in vitro Assay;in vitro testing;in vivo;Industry;Infection;Influenza;Influenza A virus;Influenza B Virus;influenza infection;influenza virus vaccine;influenzavirus;insight;interest;Intramuscular;Intramuscular Injections;intraperitoneal;Intravenous;Intravenous infusion procedures;K-Series Research Career Programs;Knowledge;Laboratory Research;Liquid substance;Longevity;Lung;member;Membrane Glycoproteins;Mentors;Methods;Modality;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mouse model;Mucous body substance;Mucous Membrane;Nebulizer;Neuraminidase;Neuraminidase inhibitor;novel;novel strategies;Nucleoproteins;Orthomyxoviridae;pandemic disease;pandemic potential;Pathogenesis;Pathology;Patient Compliance;Pharmaceutical Preparations;Phylogenetic Analysis;Physicians;Physiological;Play;Population;Positioning Attribute;pre-clinical;Preclinical Testing;prevent;professor;Program Development;prophylactic;Proteins;Public Health;receptor;Recombinants;Recording of previous events;Research;Respiratory Disease;Respiratory Mucosa;respiratory virus;response;Role;Scientist;seasonal influenza;Seasons;Sialic Acids;Site;skill acquisition;Stains;structural biology;Study models;Surface;System;Techniques;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic candidate;Therapeutic Monoclonal Antibodies;Tight Junctions;Tissue Model;Topical application;Training;Translating;translational applications;Transmission Electron Microscopy;transmission process;Vaccination;Vaccine Design;vaccine development;Vaccinee;Vaccines;vaccinology;Veterinarians;Viral;Viral Load result;Viral Pathogenesis;Virion;Virus;Virus Diseases;Virus Replication;Virus Shedding;Visualization;Vulnerable Populations;Work

PROJECT_TITLE: Discovery and characterization of protective Influenza Type B Virus neuraminidase antibodies


ADMINISTERING_IC: HL

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Rare Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SIGMOVIR BIOSYSTEMS, INC.

ORG_STATE: MD

PHR: In response to severe respiratory infections like influenza and SARS-CoV-2, a mediator of inflammation called HMGB1 is released from dying cells and leads to the “cytokine storm” associated with disease progression. Our novel inducible platform produces an inhibitor of HMGB1 in response to inflammation that is expected to counteract disease and be broadly applicable against many different inflammatory agents.

PI_NAMEs: BLANCO, JORGE C (contact);VOGEL, STEFANIE N.

PROGRAM_OFFICER_NAME: ZHOU, GUOFEI

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Address;Adenovirus Vector;Adenoviruses;Agonist;Animal Model;antagonist;Bacterial Infections;Biological Markers;cell injury;Cells;Cessation of life;chemokine;clinically relevant;Cotton Rats;COVID-19 cytokine storm;COVID-19 pandemic;cytokine;cytokine release syndrome;Data;Dengue Virus;Development;Dimerization;Disease;Disease Progression;Ebola virus;efficacy testing;Engineering;Experimental Animal Model;Family;Gene Expression;Goals;HMGB1 gene;Homeostasis;Hospitalization;Human;human disease;human pathogen;Immune response;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;inflammatory lung disease;Inflammatory Response;Influenza;influenza infection;influenza virus strain;inhibitor;Injury;Innate Immune Response;innovation;insight;Intervention;Life;Ligands;Lipopolysaccharides;Lung;Mediating;Mediator;microorganism interaction;Molecular;mouse model;Multiple Organ Failure;Mus;novel;novel strategies;pathogen;Pathway interactions;Patients;Pattern;Pattern recognition receptor;Phase;pre-clinical;Predisposition;Process;Production;prototype;Publishing;Pulmonary Inflammation;receptor;Reporting;Research;Resolution;Respiratory Disease;Respiratory Tract Infections;respiratory virus;response;Rodent Model;SARS-CoV-2 exposure;SARS-CoV-2 infection;Sepsis;Severity of illness;Sigmodon;Signal Pathway;Signal Transduction;Small Business Technology Transfer Research;small molecule;Sterility;Structure;Symptoms;System;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutic target;therapeutically effective;Tissues;TLR4 gene;Toll-like receptors;tool;translational therapeutics;Treatment Efficacy;Viral;Virus;Work

PROJECT_TITLE: Inducible HMGB1 antagonist for viral-induced acute lung injury.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-D(10)]


ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention;Social Determinants of Health

ORG_CITY: JACKSON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PI_NAMEs: CARSON, APRIL  (contact)

PROJECT_TERMS: adjudication;Adult;Affect;African American;African American population;Age Years;aged;Area;Atherosclerosis Risk in Communities;Back;Biochemical;Biological;Biological Assay;biomedical profession;Biomedical Research;Blood;Blood Vessels;brain health;Candidate Disease Gene;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;career;Catchment Area;Censuses;Cessation of life;clinical examination;cohort;Community Health Education;Community Outreach;Consent;Contracts;Coronary Arteriosclerosis;Coronary heart disease;County;Cryopreservation;Data;Data Collection;Data Linkages;Death Certificates;Development;Disease;disorder risk;DNA;Echocardiography;Eligibility Determination;Enrollment;Environmental Risk Factor;epidemiology study;Event;Family;Family member;functional status;Funding;Future;Genetic Research;genetic risk factor;Genome Scan;Health;Health Sciences;healthy lifestyle;Heart failure;Heart Ventricle;high school;Hospitalization;Hospitals;Hypertension;indexing;Institution;Investigation;Jackson Heart Study;Kidney;Learning;Left Ventricular Remodeling;Link;Lymphocyte;Mathematics;Measures;Medical;Medical Records;men;metropolitan;Minority;minority investigator;Minority Participation;minority student;Minority-Serving Institution;Mississippi;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Participant;participant enrollment;prevent;Procedures;programs;recruit;Research;Research Training;Risk Factors;Sampling;Scanning;Science;Scientist;social culture;Stroke;Telephone;Training Programs;undergraduate student;underrepresented minority student;Update;Urine;Vital Status;volunteer;Woman;X-Ray Computed Tomography

PROJECT_TITLE: JACKSON HEART STUDY (JHS) COORDINATING CENTER (CC) - TASK AREA D


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Health Services

ORG_CITY: FAIRFAX

ORG_NAME: ICF, INC., LLC

ORG_STATE: VA

PI_NAMEs: ZANAKOS, SOPHIA  (contact)

PROJECT_TERMS: Biomedical Computing;Communication;Complementary Health;Congresses;Contractor;Contracts;data management;Databases;design;Development;digital;Equipment and supply inventories;Evaluation;Exhibits;Health;Health Personnel;Healthcare;improved;Information Services;Integrative Medicine;Internet;Intervention;Intranet;Investigation;Language;Lead;Maintenance;Marketing;meetings;Methods;Mission;National Center for Complementary and Integrative Health;operation;outreach;outreach program;product development;programs;quality assurance;Quality Control;Research;Research Activity;Research Personnel;Role;Safety;Scientist;service programs;Services;social;social media;United States National Institutes of Health;web site

PROJECT_TITLE: BIOMEDICAL COMPUTING, ANALYTIC, AND DATA MANAGEMENT SERVICESTASK ORDER TITLE: NCCIH INTEGRATED INFORMATION SERVICES PROGRAM


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: COLLEGE PARK

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

PHR: Project Narrative This project is relevant to public health because about 1 in 9 US adults aged 45 years and older reports some memory loss for commonly memorable information in everyday life. Clarifying how the brain typically finds things memorable will lead to more efficient diagnosis and intervention strategies for memory impairments, especially in aging and neurological disorders (e.g., dementia and Alzheimer’s). Thus, the proposed research is relevant to NIH’s mission that pertains to the discovery of fundamental knowledge about the nature of living systems to enhance health and reduce disability.

PI_NAMEs: XIE, WEIZHEN  (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Adult;Affect;aged;Aging;Alzheimer's Disease;Anterior;Articulation;Award;Behavioral;Brain;Brain region;Cephalic;Clinical;Cognition Disorders;Computer Models;crowdsourcing;Cues;Data;Dementia;Development;Diagnosis;disability;Electric Stimulation;Electroencephalography;Elements;Environment;expectation;experience;Failure;Fostering;Goals;Health;Human;Image;improved;Individual;inferotemporal cortex;innovation;Intervention;Knowledge;knowledge base;Life;member;Memory;Memory impairment;Memory Loss;Methods;Mission;Modeling;Nature;Nervous System Disorder;neural;Neurocognitive;neuromechanism;novel;Organism;Perception;Positioning Attribute;Process;Property;Public Health;Reporting;Research;Research Personnel;Retrieval;Semantic memory;Semantics;sensory stimulus;skills;Specific qualifier value;Stimulus;Temporal Lobe;Testing;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: A Neurocognitive Basis of Remembering Driven by Prior Semantic Knowledge

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Skin Cancer

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PI_NAMEs: ZHANG, BOYU  (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Address;Adopted;Aptitude;Architecture;Area;Artificial Intelligence;Artificial Intelligence enhanced;Attention;cancer diagnosis;Categories;ChatGPT;clinical diagnosis;clinical diagnostics;Collaborations;Collection;college;combat;Communication;Complex;Computer Analysis;Computer Assisted;computer infrastructure;Computer software;computing resources;Consultations;cost;course module;Data;Data Pooling;Data Set;Databases;Decision Making;deep neural network;Dermatologist;Dermoscopy;design;Detection;Development;Diagnosis;Diagnostic;diagnostic platform;diagnostic tool;Disease;Distributed Systems;Education;Educational Activities;Educational Curriculum;Educational process of instructing;Effectiveness;Encapsulated;Engineering;Ensure;Environment;Evaluation;expectation;experience;Feedback;forgetting;Foundations;Freezing;Frequencies;Funding;Future;Generations;Goals;Grant;Health Status;holistic approach;Human;Idaho;Image;Image Analysis;improved;information gathering;Ingestion;insight;Institution;Instruction;Intelligence;intelligent personal assistant;Internet;Knowledge;Label;Language;large language model;Learning;Legal;Lesion;Letters;Life;Mammary Ultrasonography;Manuals;Measurement;Measures;Medical;Medical Education;medical examination;Medical Imaging;medical schools;Medical Students;Melanoma;Melanoma patient;Methods;Modeling;multitask;Natural Language Processing;neural network;Noise;novel;optical character recognition;Outcome;Output;Patient Simulation;Patients;Performance;Positioning Attribute;practical application;preference;Privacy;Procedures;Process;programs;Psychological reinforcement;Questionnaires;Recommendation;Reporting;Research;Resources;response;Retrieval;Rewards;Risk;Role;Sampling;Semantics;Series;service utilization;Services;skills;Skin Cancer;Structure;student participation;Students;success;supervised learning;System;Techniques;Testing;Text;Textbooks;Texture;tool;Training;training data;Translating;Translations;tumor;Ultrasonography;Universities;user-friendly;Validation;Variant;Vertebral column;virtual patient;web interface;Workload

PROJECT_TITLE: A holistic approach to interactive medical diagnosis via large language model


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE The primate retina contains an incredible diversity of retinal circuits, the majority of which have not been characterized or integrated into models of primate vision. This project will use retinal physiology, circuit tracing and measures of behavior, all in the living macaque eye, to elucidate the roles of the rare retinal output neurons in primate vision, both in health and disease. The results will clarify the timeline of retinal degeneration following V1 stroke damage and the division of labor between the retina and the brain to inform techniques that seek to restore appropriate signals in the retinas of the blind.

PI_NAMEs: PATTERSON, SARA S (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Ablation;Action Potentials;Acute;adaptive optics;Advisory Committees;Amacrine Cells;Area;Behavior;Behavioral;blind;Blindness;Brain;Calcium;career;Cell Communication;Cell Physiology;cell type;Classification;Code;Conscious;Cortical Blindness;Detection;Disease;Electrophysiology (science);experimental study;Eye;Eye Movements;Faculty;Feedback;Fluorescence;Foundations;ganglion cell;Goals;Health;Image;Imaging Techniques;improved;in vivo;in vivo calcium imaging;Individual;Investigation;Knowledge;Lasers;Lesion;Light;Link;Longitudinal Studies;Macaca;Measures;Mediating;Mentors;Modeling;Motion;neural;Neurons;Ophthalmoscopy;optical imaging;Optokinetic nystagmus;Output;Pathway interactions;Patients;Phase;Physiological;Physiology;Population;Positioning Attribute;preservation;Primates;Property;Reflex action;Research;Resolution;response;Retina;Retinal Degeneration;Retinal Ganglion Cells;Retrograde Degeneration;Role;Scanning;Signal Transduction;skills;Source;Speed;Standard Model;Stroke;Structure;Technical Expertise;Techniques;temporal measurement;tenure track;Testing;timeline;tool;Tracer;Training;Trans-Synaptic Degeneration;transmission process;Universities;Viral Vector;Vision;Visual;Visual Cortex;Visual impairment;visual information;visual neuroscience;Visual Pathways;Visual Perception;visual processing;Visual System;Visualization;voltage

PROJECT_TITLE: Linking rare primate ganglion cells to downstream visual functions

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: MILLBRAE

ORG_NAME: FRIENDI.FI CORPORATION

ORG_STATE: CA

PHR: NARRATIVE This research and development with the care.coach avatar and conversational agent will deliver an effective, meaningful, and ready-to-be-commercialized digital health intervention that adapts to the needs, preferences and goals of autistic young adults to support and benefit their health, functioning, and quality of life. The prod- uct and platform have the potential to improve the health and wellbeing of millions of Americans, including those with autism.

PI_NAMEs: KERSSENS, CHANTAL M (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TITLE: Optimizing and testing the care.coach avatar as a personalized, engaging and adaptive virtual health assistant for maximizing functional and quality of life outcomes in autistic young adults.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-C(10)B]


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research will address a significant health concern, the rise of suicide rates, by developing an adaptive time assessment system to provide a more nuanced insight into the time course of suicidal thoughts and prominent risk factors. NIH’s mission, and NIMH’s strategic priorities, will be served by the proposed study through enhanced identification of when individuals are at risk for suicide, allowing for early implementation of suicide prevention and intervention efforts and ultimately reducing suffering and mortality.

PI_NAMEs: AMMERMAN, BROOKE A;JACOBUCCI, ROSS  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TITLE: Improving momentary suicide risk identification through adaptive time sampling

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Sleep Research

ORG_CITY: COLLEGE STATION

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: Successful completion of the proposed experiments will characterize the role of astrocytic circadian clock in regulating synaptic rhythmicity and cognitive performance. There is a strong comorbidity between disruptions to the circadian cycle, and cognitive impairments, yet the mechanistic link is not well understood. We will examine how astrocytic molecular clock regulates time-of-day-dependent changes in synapse number and activity, determine the mechanisms controlling its function, and identify the rhythmic astrocytic factors that can be targeted to correct clock-related cognitive deficits.

PI_NAMEs: FARHY, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Affect;Alzheimer's Disease;AMPA Receptors;Area;ARNTL gene;Astrocytes;Behavior;Brain;Brain region;Calcium;Calcium Signaling;cell type;chordin;Chronic;circadian;Circadian Dysregulation;circadian pacemaker;Cognition;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;cognitive performance;cognitive process;comorbidity;Data;differential expression;Disease;Eating;epidemiology study;Exhibits;experimental study;Functional disorder;Future;Genes;Genetic;Glutamates;Glypican;Harvest;Health;Hippocampus;Human;Hypothalamic structure;Impaired cognition;in vivo;Investigation;Knockout Mice;Knowledge;Learning;Life Style;Light;Link;Maintenance;Mass Spectrum Analysis;Mediating;Memory;Memory impairment;memory process;Mental Depression;Modernization;Molecular;molecular clock;Mus;Nature;Nervous System Disorder;Neuroglia;Neurons;novel;Periodicity;Persons;Population;Prevalence;Process;Production;Prosencephalon;Protein Secretion;Proteins;Proteome;Publishing;receptor expression;Regulation;Research;Role;shift work;Sleep;Sleep disturbances;sleep pattern;Stress;suprachiasmatic nucleus;Synapses;synaptic function;Testing;Time;Travel;Work

PROJECT_TITLE: Regulation of Synaptic Rhythmicity by Astrocytic Clock

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Complementary and Integrative Health

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: The generation of a digital atlas of acupoints in humans is the main aim of the TARA project, and these acupoints, below the skin markers, may be embedded within the continuous and interconnected system of fascia. Fascia is the thin casing of connective tissue that surrounds and holds every organ, blood vessel, bone, nerve fiber and muscle in place. This supplement will integrate fascia-specific MRI into the TARA platform.

PI_NAMEs: HARRIS, RICHARD E;HELMER, KARL GERARD;NAPADOW, VITALY  (contact)

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: 3-Dimensional;Acupuncture Points;Adult;Anatomy;Animals;Atlases;biomechanical model;Biomedical Engineering;Blood Vessels;bone;Cadaver;Connective Tissue;Data;Data Collection;Development;digital;Dissection;Fascia;Generations;Human;Human body;human imaging;Image;imaging approach;in vivo;Knowledge;Limb structure;Link;Magnetic Resonance Imaging;Modeling;Muscle;Nerve Fibers;Organ;Participant;protocol development;Protocols documentation;recruit;repository;Research;Research Project Grants;Signal Transduction;Skin;Structure;Surface;System;Thick;Thinness;Tissues;Work

PROJECT_TITLE: Topological Atlas and Repository for Acupoint research (TARA)


FUNDING_MECHANISM: OTHERS

NIH_SPENDING_CATS: Cachexia;Cancer;Nutrition

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PI_NAMEs: GONCALVES, MARCUS DASILVA (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Adipose tissue;Affect;Algorithmic Analysis;Anorexia;Atrophic;Behavior;Body Weight decreased;Cachexia;Cancer Cachexia;Cancer Patient;carcinogenesis;chemotherapy;Clinical;clinical biomarkers;clinical phenotype;Cluster Analysis;Clustered Regularly Interspaced Short Palindromic Repeats;Cytometry;Desire for food;dietary;effective therapy;Epidemiology;host neoplasm interaction;Human;Image;imaging Segmentation;Immune;Immunology;improved;innovation;International;Intervention;Intrinsic factor;Investigation;Isotopes;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediator;Metabolic;Metabolic Diseases;Metabolic dysfunction;metabolic phenotype;Metabolism;Methods;microbial;Mission;mortality;multidisciplinary;Mus;Muscle;Neurosecretory Systems;novel;nuclear imaging;Observational Study;optogenetics;Organ;Organoids;Pathway interactions;Patients;Performance Status;Peripheral;pharmacologic;Pre-Clinical Model;Quality of life;response;Science;Scientist;Skeletal Muscle;Tissues;tool;Toxin;treatment response;tumor;tumor microenvironment;virtual;wasting;Wasting Syndrome;Work;Xenograft procedure

PROJECT_TITLE: The CANcer Cachexia Action Network (CANCAN): a Multidisciplinary Virtual Institute with the Mission to Cure Cancer Cachexia


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Disability Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Social Determinants of Health

ORG_CITY: DE KALB

ORG_NAME: NORTHERN ILLINOIS UNIVERSITY

ORG_STATE: IL

PHR: Project Narrative This project examines how school-age blind children acquire word meanings, and whether the trajectory of vocabulary development in blind children is altered or delayed relative to that in typically sighted children. Findings from this research have the potential to improve instructional approaches and language and literacy interventions for blind children.

PI_NAMEs: HARRIS, LINDSAY NICOLE (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Adult;Affect;Age;American;Area;blind;Blindness;Characteristics;Child;Child Language;Coenzyme A;cognitive development;Data Collection;Data Set;design;Developed Countries;Development;Developmental Disabilities;early childhood;Education;Environment;experience;Future;Gender;Goals;Illinois;improved;Incidence;Individual;innovation;Instruction;Intervention;Knowledge;Language;language comprehension;Language Development;language processing;Learning;Learning Disabilities;Linguistics;literacy;middle childhood;Minor;open data;Outcome;Participant;Patient Recruitments;Patient Self-Report;Pattern;Persons;Phase;Population;Positioning Attribute;Psycholinguistics;Publishing;Reading;reading ability;Reading Disabilities;recruit;Research;Research Personnel;Retinopathy of Prematurity;School-Age Population;sensory input;seventh grade;social inclusion;Socioeconomic Status;Speech;Surveys;symposium;Testing;timeline;tool;Underserved Population;Unemployment;university student;verbal;Very Low Birth Weight Infant;virtual;Vision;Visual;Visual impairment;Visually Impaired Persons;Visually Impaired Students;Vocabulary;word learning;Writing

PROJECT_TITLE: Word Learning and Vocabulary Development in Blind Children


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE - Overall This application proposes the extension of our eye and pancreas Tissue Mapping Center at Vanderbilt University associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of this Tissue Mapping Center is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of the human eye and pancreas. Our proposal leverages the unique analytical and computational resources of the Mass Spectrometry Research Center and the VU- Biomolecular Multimodal Imaging Center at Vanderbilt University, the world-class clinical environments of the Vanderbilt University Medical Center, and the unique technical expertise at the Delft University of Technology to create a capability to characterize human tissues at a level of understanding unrivaled by current technologies.

PI_NAMEs: POWERS, ALVIN C;SCHEY, KEVIN L;SPRAGGINS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Atlases;biocomputing;Body System;Cells;Clinical;Collaborations;computing resources;Data Analyses;Detection;Diabetes Mellitus;Disease;Environment;experience;Eye;Foundations;Funding;Future;Health;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging facilities;Imaging technology;indexing;Infrastructure;innovation;insight;Kidney;Laboratories;Lipids;mass spectrometric imaging;Mass Spectrum Analysis;Microscopy;Mission;Molecular;Molecular Analysis;Multimodal Imaging;Netherlands;Organ;Organ Procurements;Pancreas;Participant;Proteins;Research;Resources;Stains;Technical Expertise;Technology;tissue mapping;Universities

PROJECT_TITLE: Biomolecular Multimodal Imaging Center: 3-Dimensional Tissue Mapping of the Human Pancreas and Eye


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse;Underage Drinking;Unintentional Childhood Injury

ORG_CITY: IRVINE

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE In the last decade, the national alcohol impaired driving crash fatality rate has increased by 23% and the most recent data shows no evidence of a significant decline in the immediate future. Among driver age groups in alcohol impaired driving crashes, the 21-24y/o group is one of the most vulnerable and holds the highest proportion of alcohol impaired drivers involved in fatal crashes. Applying a policy innovation approach with the concept of an age-based reduce early risk exposure among young drivers that drink (i.e., reducing the BAC per se limit to ≥.05 from the current ≥.08 for drivers 21 through 24y/o) could yield significant reductions in alcohol impaired driving crash injury, disability, and death among drivers and their passengers while simultaneously improving the public’s safety.

PI_NAMEs: VACA, FEDERICO E (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: 21 year old;Accounting;Address;Affect;Age;age group;aged;alcohol advertising;alcohol availability;alcohol consequences;Alcohol consumption;alcohol prevention;Alcohols;Attitude;Australia;Automobile Driving;Awareness;Bacterial Artificial Chromosomes;Blood alcohol level measurement;Cessation of life;Complex;Country;Data;design;disability;drinking;drinking behavior;Drunk driving;dynamic system;effective intervention;Epidemiology;Evaluation Reports;Exposure to;Fatal injury;Fatality rate;Focus Groups;Freedom;Future;Harm Reduction;high risk;impaired driving performance;Impairment;improved;Individual;injured;Injury;innovation;International;Japan;Laws;Legal;Licensing;Life;Measurable;Methods;minimum drinking age;Modeling;models and simulation;Netherlands;novel;Participant;peer influence;Perception;Pharmaceutical Preparations;pilot test;Policies;Politics;prevent;Prevention;Reporting;Research;Resistance;Risk;Safety;simulation;societal costs;success;Surveys;Time;Translating;Transportation;US State;Utah;Vulnerable Populations;Work;young adult;Young driver;Youth

PROJECT_TITLE: Modeling a national Graduated-BAC per se policy for 21-24 y/o drivers to reduce alcohol impaired driving injury and fatal crashes

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative Mitochondria are endosymbiotic organelles that have their own genome and perform many essential functions in eukaryotic cells, including ATP synthesis via oxidative phosphorylation. Mitochondrial DNA (mtDNA) mutations cause heritable respiratory chain deficiency and contribute to a wide spectrum of diseases in humans, including metabolic disease, neurodegeneration, and cancer. The proposed research will define how mtDNA synthesis is regulated at the chromosome, organelle and cellular levels in physiologically relevant cellular and invertebrate models, and how disruption of these processes impinges on mtDNA integrity, cellular homeostasis, and ultimately human health. This work is relevant to the part of the NIH's mission that fosters fundamental basic cell biology discoveries that will directly lead to the identification of new therapeutic targets and therapies for the treatment of a wide array of human diseases.

PI_NAMEs: LEWIS, SAMANTHA C (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Alleles;Animals;ATP Synthesis Pathway;Biology;Cell Physiology;Cells;Cellular biology;Chromosomes;Complex;Disease;Eukaryotic Cell;experimental study;Fostering;Genetic Transcription;Genome;Goals;Health;Heritability;Homeostasis;Human;human disease;insight;Invertebrates;Literature;Maintenance;Malignant Neoplasms;Metabolic Diseases;Microscopy;Mission;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Respiratory Chain Deficiencies;Modeling;Molecular;mutant;Nerve Degeneration;new therapeutic target;novel;Organelles;Oxidative Phosphorylation;Pathway interactions;Physiological;Process;Proteins;Proteomics;Research;RNA;segregation;Somatic Cell;Systems Analysis;Tissues;United States National Institutes of Health;Work

PROJECT_TITLE: Systems analysis of mitochondrial genome maintenance in physiological context

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-M(55)R]


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE  This project aims to engineer, benchmark, and demonstrate the unique capabilities of an optogenetic toolbox to bi-directionally (activation and inactivation) control RhoA signaling to advance fundamental understanding of cell contractility, motility, and mechanotransduction.

PI_NAMEs: BOERCKEL, JOEL D (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3T3 Cells;Actins;Actomyosin;Animals;Behavior;Benchmarking;Biological Assay;Biology;Biophysics;Cell Line;Cell membrane;cell motility;cell type;Cells;Cellular Morphology;Collaborations;Cytoskeleton;Decision Making;density;Dependence;Development;Dimensions;Dissection;Dominant-Negative Mutation;empowerment;Engineering;Equilibrium;experimental study;Extracellular Matrix;F-Actin;Family;Feedback;flexibility;Focal Adhesions;Future;Gene Expression;Generations;Genetic;genetic payload;Genetic Transcription;Goals;GTPase-Activating Proteins;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Heterodimerization;Heterogeneity;Homeostasis;Human;Image;innovation;insight;Intercellular Junctions;Light;Link;Lipids;loss of function;Maps;Measures;mechanical force;mechanical stimulus;mechanotransduction;member;Membrane;Membrane Proteins;mesenchymal stromal cell;Metabolic;Metabolic stress;Methods;Microscopy;migration;Molecular;Monomeric GTP-Binding Proteins;Motility;Natural regeneration;Nodal;novel;operation;Optics;optogenetics;Outcome;Output;Pattern;Performance;Peripheral;Pharmacology;Photoreceptors;Physiological;polymerization;Polymers;Population;Productivity;Proliferating;Proteins;Qualifying;recruit;Regulation;Reporter;Reporting;research and development;Resolution;Resources;response;rho;Role;Signal Transduction;Spatial Distribution;spatial integration;spatiotemporal;Spectrum Analysis;Stress Fibers;Techniques;Technology;Testing;Tissues;tool;Traction;transmission process;Visualization;Zebrafish

PROJECT_TITLE: Single-component optogenetic tools to bidirectionally control RhoA in mechanotransduction

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: FARMINGTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Alcohol is the top substance used by US emerging adults under the legal drinking age (underage emerging adults; U-EA; ages 18-19). We respond to PAR-21-280 and propose to use functional magnetic resonance imaging (fMRI) to disaggregate the interaction between U-EA brain response among group MI participants (peer dyads) in the underexamined, but widely-utilized group MI context. In this study, we will examine the nature of peer-peer dyadic exchanges in the youth brain during group MI interventions (Aim 1) and predictors of behavior change: prospective relationships between youth brain response and behavior change in the novel context of group MI (Aim 2).

PI_NAMEs: FELDSTEIN EWING, SARAH W. (contact);FILBEY, FRANCESCA

PROJECT_TERMS: Adult;Aftercare;Age;age group;Alcohol abuse;Alcohol consumption;alcohol intervention;Alcohols;Behavior;behavior change;behavior prediction;Behavioral;behavioral response;biopsychosocial;blood oxygenation level dependent response;Brain;brief intervention;Client;Clinical;Data;Development;drinking;effective intervention;emerging adult;Empirical Research;Feedback;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;group intervention;hazardous drinking;Health;Iatrogenesis;improved;Individual;Intervention;Intoxication;Language;legal drinking age;Literature;marijuana use;Medial;Methods;Monitor;motivational enhancement therapy;Nature;neural;Neurocognitive;neurodevelopment;Neurosciences;novel;Outcome;Parietal;participant interview;peer;peer influence;predicting response;Prefrontal Cortex;Process;prospective;Reaction;Recording of previous events;reduced alcohol use;Research;response;Risk;Role;Safety;Sampling;Seminal;service delivery;service intervention;social cognition;Stretching;Structure of superior temporal sulcus;substance use;Time;Tobacco use;trend;underage drinking;United States National Institutes of Health;Work;Youth

PROJECT_TITLE: Do peers enhance or detract progress in group MI? A look into emerging adult brain and behavior

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: CE

IC_NAME: NATIONAL CENTER FOR INJURY PREVENTION AND CONTROL

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PI_NAMEs: TEMPLE, JEFF R (contact)

PROJECT_TITLE: RFA-CE-24-001, ICRC, Grants for Injury Control Research Centers (ICRC) - 2024


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prostate Cancer;Racial and Ethnic Minority Health Research;Social Determinants of Health;Urologic Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE  The main goal in this application is to establish whether the kinase PKCa contributes to phenotypic and outcome disparities observed in PCa in AA men. Our studies identified the kinase PKCa as an essential player in prostate cancer cell growth, tumorigenesis and invasion. We speculate that cancer cell PKCa plays a major role in the regulation of cytokine production and tumor immune cell populations, which contributes to PCa racial disparities. 1

PI_NAMEs: KAZANIETZ, MARCELO G. (contact)

PROGRAM_OFFICER_NAME: GRIL, BRUNILDE M

PROJECT_TERMS: Affect;African American;African ancestry;androgen independent prostate cancer;Automobile Driving;Biological;Biological Factors;cancer cell;Cancer Cell Growth;Cancer Etiology;cancer health disparity;Cancer Patient;Categories;Cells;Cessation of life;cohort;Collection;cytokine;Data;Databases;Death Rate;Diagnosis;Diglycerides;Disease;Disease Progression;Disparity;Distant Metastasis;Doxycycline;early onset;Etiology;European;Event;Exhibits;Family;Foundations;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Engineering;Gleason Grade for Prostate Cancer;Goals;Human;Hyperactivity;Immune;Immunocompetent;Immunohistochemistry;Immunotherapy;Impairment;implantation;in vivo;Incidence;Inflammation Mediators;Inflammatory;inhibitor;Intrinsic factor;Invaded;lifestyle factors;Malignant neoplasm of prostate;Mediating;Mediator;member;men;Metastatic/Recurrent;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;novel marker;novel therapeutics;Oncogenic;Outcome;outcome disparities;overexpression;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;Play;Population;Production;prospective;Prostate;prostate cancer cell;prostate cancer cell line;prostate cancer progression;prostate carcinogenesis;Prostatic Neoplasms;Protein Kinase C;Race;racial difference;racial disparity;Recurrent disease;Refractory;Regulation;Reporting;Research Design;response;RNA Interference;Role;Shapes;Signal Transduction;Socioeconomic Factors;Stains;Testing;Therapeutic;therapeutic target;Time;transcriptome;transcriptome sequencing;transgenic adenocarcinoma of mouse prostate;tumor;tumor growth;tumor microenvironment;Tumor-infiltrating immune cells;tumorigenesis;tumorigenic;Variant

PROJECT_TITLE: Protein kinase C signaling in prostate cancer health disparities

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: SOUTHERN RESEARCH INSTITUTE

ORG_STATE: AL

PI_NAMEs: BRONNER, RAYMOND  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Basic Science;Clinical Trials;Collaborations;Communities;Contracts;Development;Devices;Drug Kinetics;Extramural Activities;HIV;Investigational New Drug Application;Investigator-Initiated Research;Licensure;National Institute of Allergy and Infectious Disease;novel therapeutics;pre-clinical;Preparation;Private Sector;product development;Research;research clinical testing;research study;Resources;Services;Sprague-Dawley Rats;Therapeutic;United States Food and Drug Administration;Work

PROJECT_TITLE: Pharmacokinetics of Long-Acting Preparations of Telacebec


ORG_CITY: MANASSAS

ORG_NAME: AMERICAN TYPE CULTURE COLLECTION

PI_NAMEs: RASHID, SUJATHA  (contact)

PROJECT_TERMS: Basic Science;Biological;Communities;Contracts;Emerging infection;HIV;HIV/AIDS;preservation;product development;Production;programs;Reagent;Research;research and development;Research Support;Resources;Services

PROJECT_TITLE: Biological and Emerging Infections Research Resources Program (BEI-RRP): HIV/AIDS


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Lung;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PUBLIC HEALTH RELEVANCE Over 700,000 Americans receive invasive mechanical ventilation in an ICU each year. Many of these patients do not receive evidence-based therapies proven to save lives, leading to preventable morbidity and mortality. Innovative strategies to overcome the barriers to evidence-based practice and speed knowledge translation in the ICU are urgently needed. By developing novel approaches for knowledge translation in acute respiratory failure, this research program will help new treatments reach the bedside more quickly, leading to improved outcomes for critically ill patients.

PI_NAMEs: KAHN, JEREMY M (contact)

PROGRAM_OFFICER_NAME: STEFAN, MIHAELA STEFANIA

PROJECT_TERMS: Acute respiratory failure;Address;American;Behavior;biomedical informatics;Clinical Trials;Collaborations;Critical Care;Critical Illness;Electronics;evidence base;Evidence based practice;Evidence based treatment;experience;Goals;Health system;Hospitals;improved;improved outcome;innovation;Intelligence;Intensive Care;knowledge translation;Link;Measures;Mechanical ventilation;Mediator;member;Memory;Morbidity - disease rate;mortality;novel;novel strategies;Patient Care;Patient-Focused Outcomes;Patients;Performance;Physicians;Principal Investigator;programs;Psychology;public health relevance;Research;Role;Science;Scientist;Sociology;Speed;support tools;tool;Translations;uptake

PROJECT_TITLE: Organizational strategies for improving evidence-uptake in intensive care


ORG_CITY: DURHAM

ORG_NAME: FAMILY HEALTH INTERNATIONAL

ORG_STATE: NC

PI_NAMEs: PHILLIPS, TODD  (contact)

PROJECT_TERMS: Acceleration;Agriculture;Area;Attention;Centers for Disease Control and Prevention (U.S.);Child;Collaborations;Communication;Communities;design;disability;Economics;Educational workshop;Effectiveness;Evaluation;Food;food marketing;Foundations;Funding Mechanisms;Health;Healthy Eating;high risk population;improved;innovation;interest;Intervention;Knowledge;knowledge base;Leadership;Mission;obesity in children;obesity prevention;Outcomes Research;Physical activity;Policies;Private Sector;Problem Solving;Program Evaluation;programs;Public Sector;Research;Research Personnel;Resources;Schools;System;Taxonomy;Thinking;tool;Translating;trend;United States;United States National Institutes of Health;Wood material;Work

PROJECT_TITLE: NATIONAL COLLABORATIVE ON CHILDHOOD OBESITY RESEARCH (NCCOR) COORDINATING CENTER


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Patient Safety

ORG_CITY: RESTON

ORG_NAME: EDJ ASSOCIATES, INC.

PI_NAMEs: GRAY, ARIE  (contact)

PROJECT_TERMS: Cancer Therapy Evaluation Program;Contractor;Contracts;Databases;Government;Maintenance;Pamphlets;Persons;Pharmaceutical Services;Pharmacologic Substance;Policies;programs;Recovery;Regulation;Research Personnel;Services

PROJECT_TITLE: SUPPORT SERVICES FOR THE CTEP PHARMACEUTICAL MANAGEMENT BRANCH (PMB)


ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PI_NAMEs: GORANTLA, SANTHI  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Basic Science;Clinical Trials;Collaborations;Communities;Contracts;Development;Devices;Drug Kinetics;Extramural Activities;FOS gene;Genetic Transcription;HIV;HIV-1;humanized mouse;inhibitor;Investigational New Drug Application;Investigator-Initiated Research;Licensure;mouse model;National Institute of Allergy and Infectious Disease;novel therapeutics;pharmacokinetics and pharmacodynamics;pre-clinical;Private Sector;product development;Research;research clinical testing;research study;Resources;Services;Therapeutic;Transcription Factor AP-1;United States Food and Drug Administration;Work

PROJECT_TITLE: PK/PD and Effect of T-5224 on HIV-1 Transcriptional Activity in an HIV-1-Mouse Model


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Orphan Drug;Pediatric;Pediatric - AIDS;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: KENSINGTON

ORG_NAME: ADVANCED BIOSCIENCE LABORATORIES, INC.

PI_NAMEs: SILVERA, PETER  (contact)

PROJECT_TERMS: AIDS prevention;Childhood;co-infection;Collaborations;Communities;Contraceptive Agents;Contracts;Development;Devices;Extramural Activities;HIV;HIV/TB;Human;improved;Investigator-Initiated Research;Medicine;National Institute of Allergy and Infectious Disease;novel therapeutics;Pediatrics;pre-clinical;Prevention;Private Sector;product development;Research;research clinical testing;research study;Resources;Science;Sensory;Services;Taste Buds;therapeutic development;Training

PROJECT_TITLE: Expertise in Using Bitter Taste Receptor Blockers to Improve the Palatability of Pediatric Medicines: Trained Human Sensory Panels


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Atherosclerosis is the leading cause of death worldwide and obesity is a major risk factor for the development of atherosclerosis and other metabolic diseases. My exciting data show that weight loss induced by caloric- restriction promotes resolution and remission of atherosclerosis and I propose to study the underlying mechanisms. My studies will uncover novel pathways responsible for the concomitant resolution of obesity and atherosclerosis.

PI_NAMEs: WEINSTOCK, ADA  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Adipose tissue;Affect;Apoptosis;Arterial Fatty Streak;Arteries;Atherosclerosis;Blood Vessels;Body Weight decreased;bone;Bone Marrow;Caloric Restriction;Cardiovascular Diseases;Cardiovascular system;Cause of Death;Cell Physiology;Cells;Cholesterol;Chronic;Circulation;comorbidity;Data;Development;Diet;Disease;Disease Management;Disease remission;efficacious intervention;Emigrations;Epigenetic Process;Event;Foundations;Future;Genetic Transcription;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;High Fat Diet;Human;hypercholesterolemia;Immune;Immunologics;Inflammation;Inflammatory;Kinetics;Macrophage;Mediating;Medical;Metabolic Diseases;Modification;Molecular;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;novel;Obese Mice;Obesity;obesity development;Pathology;Pathway interactions;Phagocytosis;Phase;Phenotype;Population;Postdoctoral Fellow;Process;progenitor;programs;Proliferating;recruit;Research;Resolution;Risk Factors;Role;Signal Transduction;single-cell RNA sequencing;stem cell population;systemic inflammatory response;Testing;Time;tissue stem cells;Tissues;Transplantation;Work

PROJECT_TITLE: Mechanisms underlying caloric restriction-mediated resolution of atherosclerosis


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Prevention;Substance Misuse

ORG_CITY: OKLAHOMA CITY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: NARRATIVE  Despite the legalization of cannabis in multiple states (it is only fully illegal in 6), there are still no federal regulations for health warnings on cannabis products in the U.S. The fact that cannabis has adverse and therapeutic outcomes has contributed to an environment where substantial proportions of U.S. consumers both over- and under-estimate the health risks of cannabis. This project will assess adult cannabis consumers’ reactions to draft warning labels, experimentally determine how attributes of cannabis warning labels affect consumers’ emotions and perceived risks, and then develop and test our enhanced warning labels against existing labels to determine how label exposure influences perceived risk, health beliefs, and higher-risk cannabis use.

PI_NAMEs: MASSEY, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: addiction;Adult;adverse outcome;Affect;Attitude;Automobile Driving;behavior influence;Behavioral;Belief;Biological;Cancer Patient;Cannabis;Cannabis policy;Cannabis retail;cannabis use behavior;Cardiovascular Diseases;career;Characteristics;Colorado;Consumption;Data;design;Development;drugged driving;Emotions;Ensure;Environment;experience;experimental study;Focus Groups;follow-up;Future;Goals;Health;Health behavior;health belief;health communication;health knowledge;health warning;high risk;Impaired cognition;improved;innovation;insight;Intervention;Label;Learning;Legal;Literature;Lung Diseases;marijuana legalization;marijuana use;Measures;Mentorship;Methods;Motivation;multiple sclerosis patient;Nausea;novel;Outcome;Outcome Study;Participant;Patient Recruitments;Perception;Poison Control Centers;Policies;Population;Product Labeling;programs;Provider;psychologic;Psychoses;randomized, clinical trials;Reaction;Recreation;Regulation;Reporting;Research;Research Activity;Research Methodology;respiratory;Risk;risk perception;Science;Scientist;smoking cessation;Social Marketing;Source;spasticity;substance use;Testing;Text;theories;Therapeutic;therapy outcome;Time;Tobacco Control Research;Training;Training Activity;Translating;Update;Variant;warning label;Work

PROJECT_TITLE: Developing and Testing Warning Labels for Retail Cannabis Products

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: FISHER BIOSERVICES, INC.

ORG_STATE: MD

PI_NAMEs: MARTIN, BRITTANY  (contact)

PROJECT_TERMS: Adolescent;Aliquot;antiretroviral therapy;Bar Codes;Biological Markers;Biological Specimen Banks;biomarker evaluation;Cervical Cancer Screening;cervicovaginal;Child;Childhood;Communicable Diseases;Cytology;Data;Development;Enrollment;Ensure;Equipment and supply inventories;Event;Funding;General Population;HIV;HIV-exposed uninfected infant;HPV positive;Human;Human Papilloma Virus Vaccine;Human Papillomavirus;Infant;Infrastructure;Label;Lavage;Liquid substance;Malignant neoplasm of cervix uteri;Malignant Squamous Cell Neoplasm;National Institute of Child Health and Human Development;Online Systems;Participant;patient engagement;Patients;Pediatric HIV/AIDS Cohort Study;Perinatal;perinatal HIV;pregnant;prevent;programs;recruit;Reflex action;repository;Research;Risk;sample collection;Sampling;Services;Shipping;Specimen;System;Triage;Tube;United States;United States National Institutes of Health;unvaccinated;Vaccinated;vaccine effectiveness;vaccine evaluation;Woman;Work;young woman;Youth

PROJECT_TITLE: REPOSITORY SERVICES FOR MPIDB PH700 - NICHD HUMAN BIOSPECIMEN REPOSITORY


PI_NAMEs: NOBREGA, MARCELO A.;OBER, CAROLE  (contact);SPERLING, ANNE I.

PROGRAM_OFFICER_NAME: DONG, GANG

PROJECT_TITLE: Gene Discovery in Asthma and Allergic Diseases


ED_INST_TYPE: GRADUATE SCHOOLS

PHR: NARRATIVE Human genome engineering has widely anticipated promise as a healthcare strategy, but technologies in development are unlikely to safely or efficiently introduce a gene into the human genome. Starkly missing from transgene introduction strategies is an approach based on what is already quite successful across eukaryotic evolution: gene insertion by synthesis of an RNA-templated complementary DNA (cDNA). The evolutionary success of RNA template-specific, DNA site-specific LINE/non-LTR retroelement insertion begs to be engineered to develop a transgene introduction technology for human gene therapy.

PI_NAMEs: COLLINS, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: 3' Untranslated Regions;5' Flanking Region;Architecture;Biochemical;Capsid;Cell Cycle;Cell Proliferation;cell type;Cells;Clinical;Complementary DNA;CRISPR/Cas technology;Dependovirus;Development;Disease;DNA;DNA biosynthesis;DNA delivery;Engineering;Eukaryota;Evolution;Failure;Family;gene therapy;Genes;Genome;Genome engineering;Goals;Healthcare;high risk;homologous recombination;Human;Human Genetics;Human Genome;innovation;interest;loss of function;Modality;non-Native;Outcome;Pathology;Phase;Positioning Attribute;protein expression;Protein Isoforms;Proteins;repaired;Repetitive Sequence;Retroelements;Reverse Transcription;RNA;RNA chemical synthesis;RNA Sequences;Site;Specificity;success;Supplementation;Techniques;Technology;Therapeutic;Transcript;Transgenes;uptake;Virus

PROJECT_TITLE: Human genetic supplementation without donor DNA or a DNA break


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

PI_NAMEs: SAHA, KRISHANU  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TITLE: Health equity in the development of somatic cell genome editors for retinal disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer

PHR: NARRATIVE  KRAS mutations represent one of the most frequently recurrent initiating events in lung cancer. We identified protein kinase C epsilon (PKCe) as an essential player in KRAS- and carcinogen-mediated lung tumor initiation, and as an important regulator of signaling that promotes lung cancer cell motility and invasion. In this application we will investigate the molecular basis of the permissive role for PKCe in oncogenic KRAS-mediated lung tumor development and identify downstream effectors responsible for PKCe-driven lung tumorigenesis and metastatic phenotypes.

PI_NAMEs: FELDSER, DAVID ;KAZANIETZ, MARCELO G. (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Actins;Adenocarcinoma Cell;adenoma;Affect;Animals;Benzo(a)pyrene;Biology;Biosensor;cancer cell;Cancer Etiology;cancer initiation;Cancer Model;candidate identification;Carcinogens;Carcinoma;cell motility;Cell Separation;cell type;Cells;Cellular biology;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Competence;CRISPR/Cas technology;Cytoskeletal Modeling;Data;Defect;Development;Dimensions;Disease;Environmental Carcinogens;Epithelial Cells;Epithelium;Event;experience;Exposure to;Extracellular Matrix;Family;Fluorescence;Fluorescence Resonance Energy Transfer;Gene Expression;Genetic;Genetically Engineered Mouse;Germ Lines;Goals;Grant;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate;Hematopoietic;Human;In Vitro;in vivo;innovation;insight;Invaded;Joints;Knock-out;KRAS oncogenesis;KRAS2 gene;KRASG12D;Link;Lipids;LoxP-flanked allele;Lung;Lung Adenocarcinoma;lung cancer cell;lung carcinogenesis;lung metastatic;Lung Neoplasms;lung tumorigenesis;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;member;Membrane;Mesenchyme;Modeling;Molecular;Monomeric GTP-Binding Proteins;Motility;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel;Nude Mice;Oncogenic;Outcome;Patients;Peptide Hydrolases;permissiveness;Phenotype;Phorbol Esters;Phosphorylation;Phosphotransferases;Play;Positioning Attribute;Production;protein activation;Protein Analysis;Protein Deficiency;Protein Kinase C;protein kinase C epsilon;protein kinase C kinase;Publishing;rac1 GTP-Binding Protein;RAS driven cancer;Rationalization;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;Role;screening;Second Messenger Systems;Series;Signal Pathway;Signal Transduction;Stromal Cells;targeted treatment;Techniques;Testing;tumor;tumor initiation;tumor microenvironment;Tumor Promoters;tumorigenesis;Work

PROJECT_TITLE: Protein kinase C and lung carcinogenesis

STUDY_SECTION: THI

STUDY_SECTION_NAME: Tumor Host Interactions Study Section[THI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Neurosciences;Pain Research

ORG_CITY: NEW YORK

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE: Chronic visceral pain is a debilitating condition which lacks effective clinical management and represents a major unmet medical problem, which is caused by a lack of understanding of the basic mechanisms. The current proposal aims to identify unique spinal cord dorsal horn neurons and circuits involved in the pathogenesis of visceral pain in the hopes of finding novel drug targets for treating chronic visceral pain conditions.

PI_NAMEs: DUAN, BO ;HU, HONGZHEN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Affective;Afferent Neurons;Alleles;Anxiety;Awareness;Behavior;Brain Stem;Capsaicin;Cells;Chemicals;Chest Pain;Chronic;Clinical Management;Colon;Colorectal;colorectal distension;comorbidity;Complement;Conscious;Defecation;Disease;dorsal horn;excitatory neuron;Fatigue;Fiber Optics;FOS gene;FOS Protein;Functional Gastrointestinal Disorders;Genetic;Glutamates;Image;Immunohistochemistry;Impairment;implantation;in vivo;Inflammatory Bowel Diseases;Injections;Interneurons;Interoception;Intestines;Intracolonic;Investigation;Irritable Bowel Syndrome;Light;Lighting;Measures;Mechanics;Mediating;Medical;Mental Depression;Mental disorders;Molecular;Mouse Strains;Mus;Muscle Cramp;Myocardial Infarction;neural circuit;neuronal cell body;Neurons;new therapeutic target;Nodose Ganglion;Nucleus solitarius;optogenetics;Organ;Outcome Study;pain processing;pain signal;parabrachial nucleus;Pathogenesis;Pathway interactions;Patients;Perception;Peripheral;Pilot Projects;Pontine structure;Posterior Horn Cells;presynaptic;protein expression;Quality of life;Regulation;Respiration;response;Role;selective expression;Sensory;Side;Signal Transduction;Smell Perception;sound;Spinal;Spinal Cord;Spinal cord posterior horn;Spinal Injections;Stains;Stimulus;Stress;Synapses;TACR3 gene;Taste Perception;Testing;Thalamic structure;therapeutic target;Time;Touch sensation;transmission process;TRPV1 gene;Viral;Virus;Visceral;Visceral Afferents;Visceral pain;Vision;Wild Type Mouse

PROJECT_TITLE: Spinal Circuit Mechanisms of Visceral Sensory Transmission and Regulation

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Genetics;Human Genome;Pediatric

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PUBLIC HEALTH RELEVANCE Exposure to environmental agents can induce abnormal skeletal development posing lifelong implications for the patient’s health. This study is significant because it will reveal a novel mechanism whereby environmental toxicants influence osteoblast differentiation through alterations in microRNA expression. Through this, this proposal is relevant to the mission of NIH to increase understanding of how the environment affects biological processes to advance disease diagnosis, treatment, prevention, and ultimately support healthier lives.

PI_NAMEs: SPARKS, NICOLE RENEE (contact)

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Accounting;advanced disease;Adverse effects;adverse outcome;Affect;ATAC-seq;Bioinformatics;Biological;Biological Process;biomarker identification;bone;Bone Development;career development;Cells;Chemical Exposure;Chemicals;Chromatin;Communication;Complex;Congenital Abnormality;Cytogenetic Analysis;Data;Defect;Development;Development Plans;Disease;disease diagnosis;DNA;DNA Methylation;DNA methyltransferase inhibition;early embryonic stage;Electroporation;Environment;environmental agent;environmental chemical exposure;Epigenetic Process;epigenetic regulation;Etiology;experimental study;Exposure to;Failure;Frequencies;Gene Expression;Generations;Genes;Genetic;Genetic Transcription;Genome engineering;Genomics;Global Change;Goals;Health;human embryonic stem cell;Hypermethylation;in utero;In Vitro;in vivo;independency;Infant Mortality;interest;Investigation;knock-down;Knock-out;Knockout Mice;Knowledge;malformation;Mediating;Mentors;Messenger RNA;Methylation;MicroRNAs;miRNA expression profiling;Mission;Modification;Molecular;mRNA Expression;Mus;next generation sequencing;non-genetic;novel;Ontology;Operative Surgical Procedures;osteoblast differentiation;Osteoblasts;Osteogenesis;osteogenic;Outcome;overexpression;Pathway interactions;Patients;Physiologic calcification;Play;pregnant;prenatal exposure;Prevention;Principal Investigator;Process;promoter;Proteins;Public Health;public health relevance;Regulation;Repression;Research;Risk;Role;Science;Signal Pathway;skeletal;skeletal abnormality;Skeletal Development;skeletal disorder;Skeletal system;Skeleton;skills;stem;success;System;Systems Development;Testing;Therapeutic;Tissue-Specific Gene Expression;Toxic effect;Toxic Environmental Substances;toxicant;Toxicant exposure;Toxicology;Training;transcriptome sequencing;United States;United States National Institutes of Health;Untranslated RNA;Validation;Writing

PROJECT_TITLE: Analysis of environmentally-sensitive epigenetic machinery during osteogenic differentiation


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Infectious Diseases;Physical Injury - Accidents and Adverse Effects

ORG_NAME: DUKE UNIVERSITY

PI_NAMEs: CHEN, BENNY  (contact)

PROJECT_TERMS: Adaptive Immune System;adaptive immunity;Animals;antigen-specific T cells;Area;Blood Cells;cell type;Chimeric Proteins;Clinical;Contractor;cytokine;design;Exhibits;FDA approved;Human;IL7 gene;Immune response;Immunoglobulins;in vitro testing;in vivo;Infection;Influenza;irradiation;Maryland;mass casualty;Mature T-Lymphocyte;Modeling;mouse model;Murid herpesvirus 1;Natural Immunity;Peripheral;Pharmaceutical Preparations;Phenotype;preclinical study;Proliferating;Radiation;Radiation Dose Unit;Radiation exposure;Radiation induced damage;Radiation Injuries;radioresistant;Recombinants;Recovery;Risk;stem cells;T cell reconstitution;T cell response;T-Lymphocyte;Testing;Virus Diseases;Whole-Body Irradiation

PROJECT_TITLE: PROMOTING T CELL RECOVERY AFTER RADIATION INJURY WITH LONG-ACTING INTERLEUKIN 7


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Clinical Research

ORG_CITY: MENLO PARK

ORG_NAME: SRI INTERNATIONAL

PI_NAMEs: LIN, HUA  (contact)

PROJECT_TERMS: biodosimetry;Biological Assay;Biological Markers;biomarker identification;biomarker panel;Blood capillaries;Blood specimen;Classification;Data;Development;Devices;Dose;Europium;Fingers;Fluorescence;Hour;Human;Individual;Ionizing radiation;irradiation;Kinetics;lateral flow assay;mass casualty;minimally invasive;Modeling;nonhuman primate;novel;Nuclear;Plasma;Plasma Proteins;Population;protein biomarkers;Proteins;prototype;Radiation;Radiation Accidents;Reagent;Reporter;Sampling;Statistical Models;System;Time;Translations;Triage;Validation;Whole Blood

PROJECT_TITLE: DEVELOPMENT OF A NOVEL PLASMA PROTEIN BIOMARKER PANEL FOR A RADIATION/NUCLEAR TRIAGE BIODOSIMETRY DEVICE (RAPID RAD DX)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Aging;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Hematology;Human Genome;Machine Learning and Artificial Intelligence;Osteoporosis;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Somatic mutations accumulated with aging and/or in response to environmental insult and chronic inflammation can confer a selective advantage leading to clonal expansion in hematopoietic stem cells, a phenomenon termed 'Clonal Hematopoiesis of Indeterminate Potential' (CHIP). CHIP has been associated with a selective range of non-hematopoietic conditions, including coronary artery disease, stroke, heart failure, venous thromboembolism, chronic obstructive pulmonary disease, chronic liver diseases, and osteoporosis, yet the molecular mechanisms by which CHIP specifically promotes these diseases remain largely unknown. I will leverage large-scale multi-omics data to molecularly connect CHIP with the development of associated diseases and identify the mechanisms underlying CHIP-associated disease risks and thus prioritize therapeutic targets.

PI_NAMEs: YU, ZHI  (contact)

PROGRAM_OFFICER_NAME: MORALES, JOANNELLA

PROJECT_TERMS: Address;Adult;age related;Aging;Attention;biobank;Biological Process;Blood;cell type;Chronic;Chronic Disease;chronic liver disease;Chronic Obstructive Pulmonary Disease;Clonal Expansion;Coronary Arteriosclerosis;Data;deep learning;Development;dimension reduction;Disease;disease phenotype;disorder risk;Dissection;DNA;DNMT3a;early onset;Gene Expression;Gene Expression Profile;Genes;Genetic;Genomics;Germ Lines;Goals;Heart failure;Hematological Disease;Hematopoiesis;Hematopoietic stem cells;Immune;improved;Individual;Inflammasome;Inflammation;insight;instrument;Interleukin-1 beta;Interleukin-6;Lead;Liver diseases;machine learning method;Measures;Mediating;Mediation;Methods;Modeling;Modification;Molecular;Multiomic Data;multiple omics;Mutation;Myocardial Infarction;National Heart, Lung, and Blood Institute;Normal tissue morphology;Osteoporosis;Participant;Pathologic;Pathway Analysis;Pathway interactions;personalized strategies;Phase;Plasma Proteins;Population;precision medicine;prevent;protein protein interaction;Proteins;proteomic signature;Proteomics;Proxy;response;Risk;Sampling;self renewing cell;single-cell RNA sequencing;Somatic Mutation;statistical and machine learning;Statistical Methods;Stroke;Structure;Testing;therapeutic target;Tissue-Specific Gene Expression;trait;Trans-Omics for Precision Medicine;transcriptome sequencing;transcriptomics;venous thromboembolism;Work

PROJECT_TITLE: Multi-omic dissection of clonal hematopoiesis-associated diseases


ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: PROJECT NARRATIVE Almost all colorectal cancers (CRCs) have mutations that activate oncogenic Wnt/β-catenin signaling, but there are no known effective therapies targeting this pathway, and this disease remains the second leading cause of cancer deaths in the US. We found that mutations that activate Wnt signaling upstream of GSK3 induce profound sensitization to asparaginase in CRC. We propose here to investigate the molecular mechanisms through which Wnt signaling induces asparaginase hypersensitivity, which is expected to shed fundamental insights into the cellular response to amino acid starvation and its interaction with Wnt signaling.

PI_NAMEs: GUTIERREZ, ALEJANDRO  (contact)

PROJECT_TERMS: Address;Alleles;Amino Acids;asparaginase;Asparagine;beta catenin;Biology;bone;cancer cell;Cancer Etiology;Cell Physiology;Cells;Cessation of life;Clinical;Clinical Trials;colon cancer cell line;Colorectal Cancer;colorectal cancer treatment;Cytoplasm;Data;Development;Disease;Drug resistance;effective therapy;Engineering;Epithelial Cells;Event;Generations;Genetic Engineering;Genetic Screening;Genetically Engineered Mouse;genome-wide;Hematopoietic;Human;Hypersensitivity;Immunotherapy;Impairment;improved;inhibitor;innovation;insight;Intestines;Knowledge;KRAS oncogenesis;KRAS2 gene;leukemia;Life;Ligands;Maps;Mediating;Modeling;Molecular;mortality;mouse model;multicatalytic endopeptidase complex;Mus;Mutation;Oncogenic;Organoids;Outcome;Pathway interactions;Patients;pharmacologic;Phase;predictive modeling;progenitor;prospective;protein activation;protein degradation;Proteins;rational design;receptor;Resistance;response;Role;Series;Signal Induction;Signal Transduction;Source;Starvation;syndecan;System;targeted treatment;Testing;Therapeutic;Therapeutic Index;Therapeutic Intervention;therapy resistant;Toxic effect;TP53 gene;Translating;treatment response;tumor;Ubiquitin;Ubiquitination;WNT Signaling Pathway

PROJECT_TITLE: Biology of R-Spondin-Induced Sensitization to Asparaginase in Colorectal Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


PHR: Project Narrative The antileukemic drug asparaginase is a central component of curative therapy for several acute leukemias, but the development of resistance is a major clinical problem with a poor prognosis. We found that inhibition of the kinase GSK3α induces asparaginase sensitization in several drug-resistant subtypes of acute leukemia. We propose to investigate the biology underlying this potent therapeutic interaction, which is expected to provide fundamental insights into the amino acid starvation response, and allow its rational therapeutic exploitation for maximal clinical benefit.

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Acute leukemia;Acute Lymphocytic Leukemia;Acute Myelocytic Leukemia;Address;Amino Acids;Anabolism;antileukemic agent;asparaginase;Asparagine;B-Cell Acute Lymphoblastic Leukemia;beta catenin;Biology;cancer therapy;Carcinoma;Cell Cycle Arrest;Cell Death;Clinical;Colon Carcinoma;curative treatments;Cytoplasmic Inclusion;Data;Disease;Drug resistance;Drug Sensitization;Enzymes;experimental study;Generations;Genetic Screening;genome-wide;glycogen synthase kinase 3 beta;Hematopoietic stem cells;high risk;Human;improved;in vivo;inhibitor;innovation;insight;interest;Knowledge;leukemia;leukemia relapse;Leukemic Cell;logarithm;Malignant Neoplasms;Mediating;Modeling;Molecular;Mus;Mutation;Myeloid Leukemia;N-terminal;Non-Essential Amino Acid;Normal Cell;Oncogenic;paralogous gene;Pathway interactions;patient derived xenograft model;Phase;Phenocopy;Phosphorylation;Phosphotransferases;Process;Prognosis;prospective;protein degradation;Protein Isoforms;Proteins;Refractory;Regulation;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;Signal Transduction Induction;Source;Starvation;synthetic lethal interaction;Testing;Therapeutic;Therapeutic Index;therapeutically effective;Toxic effect;Translating;treatment response;Ubiquitination;WNT Signaling Pathway

PROJECT_TITLE: Defining and targeting asparaginase resistance mechanisms in high-risk acute leukemias

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Osteocytes serve as the major orchestrator of skeletal metabolism and many pathologic or disease conditions can now be ascribed to disrupted osteocyte functions. This proposal describes an innovative and comprehensive approach to investigate the osteocytic role of the transcription factor SP7. Ultimately, the long-term goal of this study is to determine not only how osteocyte-enriched genes function in bone disease, but also to enable the development of next generation therapeutics for skeletal diseases that target osteocyte development.

PI_NAMEs: WANG, JIALIANG  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Acceleration;Address;Affect;Applications Grants;Award;Bioinformatics;Biology;bone;Bone Development;Bone Diseases;bone health;Bone Resorption;Brain;career;Cell Culture Techniques;Cell Surface Extensions;cell type;Cells;Communication;Complex;Data;Dendrites;Development;Disease;Ensure;Etiology;Faculty;Future;gene function;gene regulatory network;Genes;Genetic;Genetic Transcription;genome wide association study;Goals;Grant;Homeostasis;Human;Human Characteristics;In Vitro;in vitro testing;in vivo;innovation;interdisciplinary collaboration;Investigation;Knowledge;Lasers;Link;Mentorship;Metabolism;Methods;Microdissection;Modeling;Molecular;mouse model;Mus;Mutation;Neurons;neuropeptide Y;Neurosciences Research;novel;novel therapeutics;osteoblast differentiation;Osteoblasts;Osteocytes;Osteogenesis;Osteogenesis Imperfecta;Osteoporosis;Pathologic;Pathway interactions;Patients;Pattern;Phase;Phenotype;Positioning Attribute;Process;programs;Publications;Regulation;Regulatory Element;Research Personnel;Role;Signal Pathway;single-cell RNA sequencing;skeletal;skeletal abnormality;skeletal disorder;targeted treatment;tenure track;Training;transcription factor;transcriptome;transcriptomic profiling;transcriptomics;Transgenic Mice;Variant;Work

PROJECT_TITLE: Comprehensive investigation of SP7 during the osteoblast-to-osteocyte transition

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]