NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Organ Transplantation;Patient Safety;Rare Diseases;Transplantation

ORG_CITY: TORONTO

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: Project Narrative Globally, access to lung transplantation for high risk patients varies significantly due to a lack of consensus regarding their eligibility. Our project will compare how different lung transplant centers manage these patients, which will help us to develop new standard guidelines for their care. Ultimately, this will allow more patients to receive a surgery that reduces their illnesses and saves their lives.

PI_NAMEs: AVERSA, MEGHAN M;KESHAVJEE, SHAF  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: access disparities;Acute Respiratory Distress Syndrome;Address;Affect;Age;antibody-mediated rejection;Body mass index;Boston;candidate selection;Caring;Categories;Cells;Clinical;Collaborations;Complement;Consensus;COVID-19;COVID-19/ARDS;Critical Illness;Data;desensitization;Disadvantaged;Disparity;Donor person;donor-specific antibody;Eligibility Determination;Ensure;Exercise;experience;Extracorporeal Membrane Oxygenation;Florida;Future;Goals;graft dysfunction;Guidelines;Health;health related quality of life;high risk;Hospitals;Immunosuppression;Improve Access;improved;improved outcome;Individual;International;Leadership;Length of Stay;Life;Lung;Lung Diseases;Lung Transplantation;Mechanical ventilation;Mechanics;mortality;multidisciplinary;New York;Operative Surgical Procedures;organ allocation;Outcome;Patient Participation;Patient-Focused Outcomes;Patients;Perioperative;Physical therapy;Positioning Attribute;post-transplant;Predictive Factor;Procedures;Process;programs;Prospective, cohort study;Protocols documentation;Pulmonology;Quality of life;Regimen;Research;Risk;Sedation procedure;Selection Criteria;Site;Standardization;Thoracic Surgical Procedures;Time;transplant centers;Transplant Recipients;Transplantation;Uncertainty;United States National Institutes of Health;Universities;Variant;virtual;Waiting Lists;Walking;willingness;Woman

PROJECT_TITLE: CATCH: Creating Access to Transplant for Candidates who are High Risk


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Brain Disorders;Clinical Research;Dementia;HIV/AIDS;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Prevention;Primary Health Care

ORG_CITY: Oakland

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

ORG_STATE: CA

PHR: PROJECT NARRATIVE People living with HIV are at increased risk for developing dementia despite treatment with antiretroviral therapy. Dementia risk scores based on measures routinely collected in primary care may assist clinicians in identification of individuals who could benefit from earlier targeted intervention or cognitive screening. The proposed K01 Career Development Award will support Dr. Jennifer Lam in the completion of a mentored research project and acquisition of skills necessary for future independent research on the prevention and management of dementia in people with HIV.

PI_NAMEs: LAM, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acceleration;Address;advanced analytics;Affect;Age;age related;Age related comorbidities;age related neurodegeneration;aged;Aging;analytical method;antiretroviral therapy;Behavioral;Biometry;Cardiovascular Diseases;care providers;career;Caring;CD4 Lymphocyte Count;Chronic;Chronic Disease;Clinic;Clinical;clinical care;clinical implementation;clinical practice;Cognitive;cognitive function;cohort;Communicable Diseases;Communities;comorbidity;Comprehensive Health Care;Consequences of HIV;Data;Dementia;dementia burden;dementia risk;Development;Disease;Doctor of Philosophy;Early identification;Electronic Health Record;Ensure;Epidemiologist;Epidemiology;Evaluation;Evaluation of Risk Factors;experience;Face;follow-up;Foundations;Funding;Future;Goals;Guidelines;Health;health care delivery;health care settings;Healthcare Systems;high risk;HIV;HIV Infections;Impaired cognition;implementation science;improved;Incidence;Individual;Inflammation;Intervention;Interview;K-Series Research Career Programs;late life;Life Expectancy;Measures;Mediating;Medical;Mentors;Mentorship;Methodology;model development;Modeling;Monitor;Neurocognitive;neurocognitive disorder;Neurology;novel;Older Population;Patients;Performance;Persons;Population;Positioning Attribute;predictive modeling;premature;Prevention;Primary Care;prototype;Provider;psychiatric comorbidity;Research;Research Personnel;Research Project Grants;Risk;Risk Factors;risk prediction;risk stratification;Sampling;Science;screening;Severities;skill acquisition;skills;sociodemographics;Stratification;substance use;support tools;System;technique development;Testing;Time;tool;Training;Training Programs;Translations;Uncertainty;United States National Institutes of Health;Validation;Work

PROJECT_TITLE: Electronic Health Record-Based Dementia Prediction for HIV Primary Care

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Organ Transplantation;Pneumonia and Influenza;Prevention;Transplantation;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Lung transplantation is a life-saving cure but is limited by graft failure. The creation of a national Lung Transplantation Consortium holds great promise for uniting physicians and scientists to improve patient outcomes. Our Center focuses on understanding why lung transplant recipients respond poorly to vaccinations so that better life-preserving vaccines can be designed.

PI_NAMEs: DHILLON, GUNDEEP SINGH;NICOLLS, MARK ROBERT (contact);PULENDRAN, BALI

PROJECT_TERMS: 2019-nCoV;Acute;Address;Adjuvant;Adopted;Antibody Response;Antibody titer measurement;Antimetabolites;Assessment tool;B-Lymphocytes;biobank;bioinformatics tool;Biological Assay;Budgets;CD4 Positive T Lymphocytes;Cellular Immunity;Cessation of life;Chickenpox;Child;Clinical;clinical center;Cohort Studies;comorbidity;Complex;Computer Analysis;COVID-19;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;cytokine;Cytometry;Data;design;diabetic patient;Dose;Enzyme-Linked Immunosorbent Assay;Fostering;Future;geographically distant;Glean;graft failure;Grant;Healthcare;Hemagglutination;Herpes zoster disease;Housing;Humoral Immunities;Immune response;Immunity;Immunize;Immunocompromised Host;immunogenicity;Immunophenotyping;immunosuppressed;Immunosuppression;Immunosuppressive Agents;Impairment;improved;Individual;Infection;Infection prevention;Influenza;Influenza vaccination;influenza virus vaccine;Investigation;Life;longitudinal dataset;Lung infections;Lung Transplantation;Machine Learning;Measures;Medical;Messenger RNA;Methodist Church;Methodology;Molecular;Natural Immunity;neutralizing antibody;older patient;organ transplant recipient;pandemic disease;Patient Recruitments;Patient-Focused Outcomes;Patients;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phenotype;Physicians;Plasma;Plasma Cells;Plasmablast;preservation;programs;prospective;Protocols documentation;Recording of previous events;Research;Resource Sharing;response;Risk;RNA vaccine;Scientist;Solid;Streptococcus pneumoniae;System;Systems Biology;T-Lymphocyte;Testing;Time;tool;Transplant Recipients;Transplantation;United States National Institutes of Health;Vaccinated;Vaccination;vaccination protocol;vaccination strategy;Vaccine Design;vaccine efficacy;vaccine immunogenicity;vaccine response;Vaccines;vaccinology;Virus;Vulnerable Populations

PROJECT_TITLE: Vaccination responses in lung transplant recipients


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LA JOLLA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative A plant virus nanotechnology-based immunotherapy will be developed against metastatic tumors. Specifically, good manufacturing practices (GMP)-compatible, scalable methods for molecular farming of the nanotechnology in plants will be developed; efficacy, pharmacology and toxicology will be evaluated in tumor mouse models and canine patients to set the foundation for translation into clinical trials and practice. Successful completion would enable GMP manufacture, IND-enabling pharmacology, and First-Time-In-Human trial of the plant virus cancer immunotherapy.

PI_NAMEs: FIERING, STEVEN ;RANJAN, ASHISH ;STEINMETZ, NICOLE FRANZISKA (contact)

PROGRAM_OFFICER_NAME: HARRIS, RAYMOND D

PROJECT_TERMS: Abscopal effect;anti-tumor immune response;Antigens;Antitumor Response;Applications Grants;arm;Award;Biodistribution;Biological;Biological Markers;Biopsy;Biotechnology;Blood;cancer immunotherapy;Cancer Intervention;Canis familiaris;cell killing;Cells;Chemistry;Chromatography;Chronic;Clinical;clinical practice;Clinical Trials;Collaborations;companion animal;Cowpea Mosaic Viruses;Data;Development;Disease remission;Dose;drug candidate;Enrollment;Environment;Evaluation;experience;Fabaceae;Farm;Feces;Formulation;Foundations;Funding;Future;Genomics;Goals;Good Manufacturing Process;Human;Image;Immune;Immune system;immunoengineering;Immunologic Memory;Immunologic Stimulation;Immunologics;Immunosuppression;Immunotherapy;immunotherapy trials;improved;in situ vaccination;in situ vaccine;Industry Standard;Inflammation;Injections;Innate Immune System;Intellectual Property;intervention program;Investigation;Investigational Therapies;Leadership;Licensing;Malignant Breast Neoplasm;Malignant Neoplasms;Mammals;manufacture;manufacturing facility;Mast Cell Neoplasm;Mediating;Melanoma;method development;Methodology;Methods;Modeling;Molecular;Monitor;mosaic;Mosaic Viruses;mouse model;Mus;nanoparticle;Nanotechnology;Nanovirus;neoantigens;Neoplasm Metastasis;neoplastic cell;Oncogenic Viruses;Oncology;oncology trial;Organ;patient subsets;Patients;personalized approach;Pharmacology;Pharmacology and Toxicology;Phase 0 Clinical Trial;Plant Viruses;Plants;Positioning Attribute;prevent;Production;programs;Protocols documentation;recruit;Recurrence;residence;Safety;Sarcoma;Site;Structure;success;systemic toxicity;Techniques;Technology;Time;Toxic effect;Toxicology;Translating;Translational Research;Translations;treatment response;tumor;Tumor Antigens;Tumor Burden;Tumor Immunity;tumor immunology;Tumor Markers;tumor microenvironment;Urine;vaccine candidate;Vaccine Therapy

PROJECT_TITLE: Toward translation of a plant virus-based in situ vaccination nanotechnology


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE  Between 2020 and 2021, US policy changes will require increased visibility of information about calories, serving sizes and added sugars on the back or side of packaged foods. During the same time, Mexico will put “stop sign” warnings on the front of packaged foods that are high in calories, sodium, sugar, or fat, as well as on products with added caffeine or sweeteners. This study will analyze surveys of Mexicans and Americans, including Mexican Americans, to evaluate labeling policy effects on nutrition knowledge and healthy eating, including which policy is most effective for people with limited resources.

PI_NAMEs: DAVIS, RACHEL ELLEN;THRASHER, JAMES  (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Address;Adopted;Adult;American;Awareness;Back;Behavior;Beverages;Body mass index;Caffeine;Calories;Cardiovascular Diseases;Communication;communication theory;consumer behavior;Consumption;cost;Country;Data;design;Diabetes Mellitus;Diet;dietary;Disadvantaged;Disease;Disparity;Disparity population;Education;ethnic minority population;experimental study;Fatty acid glycerol esters;Food;food environment;Food Labeling;Food Packaging;Food Policy;food security;Funding;Goals;Health;health disparity;health equity;Health Food;health literacy;Healthy Eating;High Prevalence;improved;innovation;Intake;International;Interruption;Intervention;Knowledge;Label;Latinx;Location;Low income;Malignant Neoplasms;Mexican;Mexican Americans;Mexico;nutrition;Nutrition Labeling;Nutritional;obese person;Obesity;Outcome;Pattern;Persons;Policies;Policy Developments;Population;post implementation;Prevalence;Product Labeling;recruit;relative effectiveness;Resources;response;Sampling;saturated fat;Secure;Series;Side;simulation;Sodium;sugar;Surveys;sweetened beverage;Sweetening Agents;Time;Time Series Analysis;Trans Fats;trend;Unhealthy Diet;United States;warning label;Work

PROJECT_TITLE: Evaluating nutrition labeling policy changes in the US and Mexico.

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: DURHAM

ORG_DEPT: ORTHOPEDICS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The proposed research will provide new understandings on the role of deficient lubrication in the development of osteoarthritis after joint injury. Successful completion of the proposed study will lead to a new class of self- repairing lubricants to treat joint injuries to ameliorate or delay cartilage degeneration or as an adjunct after surgical repair to improve the outcome.

PI_NAMEs: VARGHESE, SHYNI  (contact);ZAUSCHER, STEFAN

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Acute;Adhesions;Adhesives;Animal Model;anterior cruciate ligament injury;anterior cruciate ligament reconstruction;Architecture;articular cartilage;Atomic Force Microscopy;Bone Tissue;Cartilage;cartilage degradation;Cartilage injury;Charge;chondroprotection;Clinic;Clinical;Degenerative polyarthritis;design;Deterioration;Development;Electrostatics;Engineering;Ensure;Exhibits;Extracellular Matrix;Family suidae;Formulation;Friction;Goals;healing;Histologic;Hyaluronic Acid;Image;improved;improved outcome;in vivo;Individual;inflammatory marker;Injury;Intervention;Intra-Articular Injections;joint injury;Joints;Liquid substance;Lubricants;Lubrication;lubricin;Lysine;Measurement;Mechanics;Modeling;Molecular;Molecular Weight;Monitor;Movement;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pain;prevent;Property;Pyrimidinones;repaired;Research;Role;Saline;Slide;success;Surface;Synovial Fluid;Synovial Membrane;Time;Tissues;Trauma;Traumatic Arthropathy;United States;Weight-Bearing state

PROJECT_TITLE: Molecular engineering of HA-based lubricants for articular cartilage

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: ATLANTA

ORG_DEPT: PEDIATRICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PI_NAMEs: SHEEHAN, VIVIEN ANDREA (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Affect;Area;base;Basic Science;career;Cities;Clinical Sciences;Collaborations;Communication;Communities;Competence;Data Analyses;Development;Disease;Environment;experience;Feedback;Future;Goals;graduate student;Grant;Health;Hematology;Historically Black Colleges and Universities;Human;improved;innovation;Institution;Interdisciplinary Study;Kidney;Leadership;Legal patent;Manuscripts;member;Mentors;Mentorship;Morehouse School of Medicine;Oral;peer;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Program Development;programs;Publishing;recruit;Research;Research Technics;Research Training;Resources;skills;success;Talents;Technology;TNFSF15 gene;Training;training opportunity;Translational Research;undergraduate student;Underrepresented Minority;Universities;urologic;Woman;Work;Writing

PROJECT_TITLE: Atlanta Network for Training In KUH Scientific Research (ATLANTIS)


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Transplantation

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative  Extremity trauma involving volumetric muscle loss (VML) presents a clinical challenge with significant fibrosis and fatty infiltration, impaired regeneration, and long-term functional disabilities. In this work, we will use pre-clinical models to define the roles of key cell types in the pathologic process of VML. We then utilize this foundational understanding to develop newly engineered immunomodulatory and regenerative treatment strategies with the long term goal of translating these into clinical treatments to improve functional outcomes after VML injuries.

PI_NAMEs: WILLETT, NICK J (contact)

PROJECT_TERMS: Adipose tissue;analytical method;Animals;Attenuated;Autologous Transplantation;Biocompatible Materials;Cell Count;Cell Differentiation process;Cell Lineage;Cell Physiology;Cell Proliferation;Cell Transplantation;cell type;Cells;Characteristics;Chronic;chronic pain;Clinical;Clinical Treatment;Coculture Techniques;controlled release;CXCR4 gene;Cytometry;Data;Defect;Development;directed differentiation;Encapsulated;Engineering;Engraftment;Environment;experimental study;Fibrosis;Foundations;functional disability;functional improvement;functional outcomes;Functional Regeneration;Gait;General Population;Goals;healing;Histology;Hydrogels;Immune;immunoengineering;immunomodulatory therapies;immunoregulation;Impairment;In Vitro;in vivo;Infiltration;Inflammation;Injury;Integrins;Interleukin-10;Interleukin-4;Isometric Exercise;Lead;limb injury;lipid mediator;Liposomes;Macrophage;Maleimides;mesenchymal stromal cell;Military Personnel;Modeling;Molecular;monocyte;Mus;Muscle;muscle engineering;Muscle Fibers;muscle progenitor cell;muscle regeneration;Muscle satellite cell;Muscular Dystrophies;Myeloid Cells;myogenesis;Natural regeneration;novel;novel therapeutic intervention;Operative Surgical Procedures;Outcome;Pathologic Processes;Pathology;Phenotype;Play;Polyethylene Glycols;pre-clinical;Pre-Clinical Model;Process;Production;Profibrotic signal;Proliferating;Publications;quadriceps muscle;Recovery of Function;regeneration potential;regenerative;regenerative treatment;repaired;response;Role;Saline;scaffold;Series;Signal Transduction;Sorting;stem cell function;stem cell niche;stem cell proliferation;Stem cell transplant;stem cells;System;Testing;Thick;Time;Tissue Engineering;Tissues;Torque;Transgenic Animals;Translating;Transplantation;Treatment Efficacy;treatment strategy;volumetric muscle loss;Work

PROJECT_TITLE: Engineering the Immune and Fibrotic Response in Volumetric Muscle Loss

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


NIH_SPENDING_CATS: Dissemination and Implementation Research;Hematology

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PI_NAMEs: MARIANI, LAURA H (contact)

PROJECT_TERMS: Area;Basic Science;bench-to-bedside translation;Bioinformatics;career;Clinical;clinical practice;Clinical Trials;Conceptions;Doctor of Philosophy;Environment;Epidemiology;Ethics;experience;Faculty;Genomics;Health;Health Sciences;Health Services Research;Healthcare;Hematology;implementation research;implementation science;Institution;Kidney;matriculation;Medical;Medicine;Mentors;metabolomics;Methodology;Michigan;Monitor;Peer Review;Philosophy;Physicians;population health;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;programs;Proteomics;Public Health;Publications;Records;Research;Research Design;Research Project Grants;Research Training;Review Literature;Science;Scientist;skills;symposium;Systems Biology;Techniques;Testing;theories;TNFSF15 gene;Training;Training Programs;transcriptomics;Translating;Translational Research;Universities;Urology;Work

PROJECT_TITLE: Training Core


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Breastfeeding, Lactation and Breast Milk;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nutrition;Pediatric;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE COVID-19 cases and hospitalizations among children have spiked dramatically worldwide, and children are an important source of community transmission; however, COVID-19 immunity studies have predominantly focused on adults due to ease of sample collection and exclude children whose immune systems are still developing. This proposal addresses the critical need to study the short- and long-term immune responses to the COVID-19 mRNA vaccine in adolescents, children, and mother-infant pairs and to identify correlates of protection against breakthrough infection. The results will inform policy makers and scientists on how to optimize COVID-19 vaccination strategies to effectively protect children and decrease community transmission.

PI_NAMEs: PANNARAJ, PIA S (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 2019-nCoV;Address;Adolescent;Adult;Age;age group;Age Months;Antibodies;Antibody Response;Bar Codes;Bioinformatics;Biological;Biological Assay;Blood specimen;breakthrough infection;Breast Feeding;Breastfed infant;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Cellular Immunity;Child;Clinical Trials;cohort;community transmission;COVID-19;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;DNA;Dose;Early identification;Enrollment;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemiology;Epitopes;Exclusion;experience;FDA Emergency Use Authorization;Genetic Transcription;high risk;Hospitalization;Household;Human Milk;Humoral Immunities;Immune response;Immune system;Immunity;Immunoglobulin A;Immunoglobulin G;Immunologics;Immunology;Individual;Infant;Infection;Lactation;Life;Longevity;Maternal Messenger RNA;maternal vaccination;Measures;Methods;Milk;Mothers;Mucosal Immunity;Mucous Membrane;neutralizing antibody;Nose;Participant;Pathway interactions;Peripheral Blood Mononuclear Cell;Pfizer-BioNTech COVID-19 vaccine;Policy Maker;Population;predicting response;pregnant;prevent;Proteins;Recording of previous events;Respiratory System;response;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA vaccination;RNA vaccine;Saliva;sample collection;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 exposure;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 spike protein;Scientist;Secretory Immunoglobulin A;Serology;Serum;Site;Source;Specimen;Stains;Structure of mucous membrane of nose;symptomatic COVID-19;System;T cell receptor repertoire sequencing;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Time;Tissue-Specific Gene Expression;transcriptomics;transmission process;United States;Up-Regulation;Upper respiratory tract;Vaccination;vaccination strategy;vaccine evaluation;vaccine immunogenicity;vaccine-induced immunity;Vaccines;vaccinology;Viral;virology;Whole Blood

PROJECT_TITLE: Longitudinal SARS-CoV-2 mRNA vaccine-induced mucosal, serological, and cellular immunity in children and human milk

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Prevention

ORG_CITY: BATON ROUGE

ORG_NAME: LSU PENNINGTON BIOMEDICAL RESEARCH CTR

ORG_STATE: LA

PHR: Project Narrative Despite the importance of dietary composition and food choice to health, and despite persistent dietary advice to change eating habits, we know almost nothing about how the brain controls dietary macronutrient choice. This project will define the brain areas and neural phenotypes mediating FGF21-dependent changes in feeding behavior, thereby uncovering a novel set of neural circuits that regulate food choice.

PI_NAMEs: MORRISON, CHRISTOPHER D (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Animals;Area;Automobile Driving;Behavioral;Behavioral Mechanisms;Biology;Brain;brain control;Complex;Consumption;Data;Diet Habits;dietary;dietary control;Dopamine;Eating;Energy Intake;Environment;Exhibits;experimental study;Family member;feeding;Feeding behaviors;FGF21 gene;Fibroblast Growth Factor;fibroblast growth factor 21;Food;Food Intake Regulation;Genetic Models;Health;Homeostasis;Hormones;Individual;insight;Learning;Liver;Macronutrients Nutrition;Mammals;Mediating;Metabolic;Metabolism;Methodology;molecular phenotype;motivated behavior;Motivation;mouse genetics;Mus;neural;neural circuit;neurobehavioral;neurobiological mechanism;Neurobiology;neuromechanism;Neurons;novel;Nutritional;pharmacologic;Phenotype;Physiological;Population;protein intake;Protein-Restricted Diet;Proteins;receptor;Regulation;response;Role;Signal Transduction;Signaling Protein;Site;System;Taste Perception;Testing;virtual;Work

PROJECT_TITLE: Neural circuits coordinating protein intake: Role of FGF21

STUDY_SECTION: NNRS

STUDY_SECTION_NAME: Neuroendocrinology, Neuroimmunology, Rhythms and Sleep Study Section[NNRS]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Cancer immunotherapies represent a powerful therapeutic paradigm because they are applicable to a wide variety of tumors and can produce durable clinical responses; however, only a fraction of patients experience clinical benefit from current immunotherapies, and there is a need to develop new therapies. Our studies will uncover novel mechanisms by which a certain protein affect immune responses to malignancies, particularly in the immune system's T cells, to successfully disable cancer cells.

PI_NAMEs: MOR, ADAM  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Adaptor Signaling Protein;Address;Affect;anti-PD-1;anti-tumor immune response;Antibodies;Articulation;Biochemical;Biological Assay;Biology;Blocking Antibodies;cancer cell;cancer immunotherapy;Cell Physiology;Cells;checkpoint therapy;Clinical;clinical application;Clinical Trials;Colon Carcinoma;Cytoplasm;Cytoplasmic Tail;cytotoxicity;Data;experience;experimental study;Fluorescence Microscopy;Genetic;Glycosphingolipids;Goals;Human;Imaging Techniques;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immune signaling;Immune system;Immune Targeting;Immunization;immunological synapse;Immunotherapy;In Vitro;in vivo;innovation;Integral Membrane Protein;Intervention;Knockout Mice;Label;Ligand Binding;Lipid Bilayers;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of testis;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mediating;Membrane;Microscopy;Modeling;Molecular;Mutagenesis;new therapeutic target;novel;novel therapeutics;Pathway interactions;Patients;Peptides;Phosphoproteins;phosphoproteomics;Phosphorylation;Phosphorylation Site;Phosphotransferases;prevent;programmed cell death protein 1;Proteins;Protocols documentation;Published Comment;receptor;recruit;Resolution;Resources;response;Role;Signal Transduction;T-Cell Activation;T-Cell Antigen Receptor Specificity;T-Cell Receptor;T-Lymphocyte;Testing;Therapeutic;therapeutic candidate;Transgenic Mice;Translating;tumor;tumor growth;Tyrosine

PROJECT_TITLE: PAG is a novel target in immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Autistic adults experience adverse aging outcomes that manifest early and confer significant personal and public health costs, including higher rates of chronic health deterioration, cognitive decline, and mortality. The proposed research will leverage epigenetic markers that can detect deviations in cellular aging years before the onset of overt declines, thus helping to identify autistic persons most at risk of poor outcomes and the factors contributing to risk variations in this vulnerable population. Understanding how early clinical and environmental factors in autism coalesce to influence biological aging processes may ultimately inform preventive strategies to mitigate subsequent health and longevity disparities by minimizing risk exposures and promoting identified protective factors across the lifespan.

PI_NAMEs: DICKINSON, ABIGAIL H (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: accelerated epigenetic aging;Address;Adult;adult with autism spectrum disorder;Adverse event;adverse outcome;Affect;Age;age acceleration;age related;age related decline;Age Years;Aging;aging biomarker;aging brain;aging mechanism;aging process;Algorithms;American;Anxiety;autism spectrum disorder;Behavior;behavior influence;Behavioral;Biological;biological age;Biological Aging;Body mass index;Brain;Cardiovascular Diseases;catalyst;Cell Aging;Characteristics;Child;Childhood;Chronic;Chronic Disease;Chronology;Clinical;Clinical Data;Clinical Management;clinically relevant;Cognitive;Cognitive aging;cognitive function;cohort;Communication impairment;comorbidity;Data;Deterioration;Development;Diabetes Mellitus;dimension reduction;Disabling;Disease;Disparity;DNA Methylation;early childhood;Early Diagnosis;Electroencephalography;emerging adult;environmental intervention;Environmental Risk Factor;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;experience;Face;Foundational Skills;Foundations;Frequencies;functional decline;Future;General Population;Goals;Health;Health Care Costs;high risk;human old age (65+);Impaired cognition;Impairment;improved;improved outcome;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;insight;Investigation;K-Series Research Career Programs;Life;Life Expectancy;life span;Link;Longevity;Longitudinal cohort;Machine Learning;Malignant Neoplasms;Measurement;Measures;Mental Depression;Mentors;Methodology;Methods;methylation pattern;middle age;Modeling;Molecular;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Mental Health;Nerve Degeneration;neural;Neurodegenerative Disorders;neurophysiology;Neurosciences;novel;Older Population;Outcome;Participant;patient population;Pattern;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Population;Predisposition;Prevention;Prevention strategy;preventive intervention;Procedures;Process;programs;promote resilience;prospective;protective factors;Proxy;psychosocial stressors;Public Health;repetitive behavior;Reporting;Research;resilience factor;Rest;Risk;Risk Factors;risk minimization;risk mitigation;Saliva;Sampling;Schools;Sensory impairment;sex;skills;social;Social isolation;Stress;Surrogate Markers;Symptoms;Techniques;Time;Training;United States;Variant;Vulnerable Populations;young adult

PROJECT_TITLE: Social, Cognitive, and Behavioral Influences on Early Life Aging in Autism

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Radiation Oncology;Rural Health;Social Determinants of Health

ORG_CITY: CHARLESTON

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

PHR: PROJECT NARRATIVE Continuation of the Medical University of South Carolina NCORP Minority/Underserved Community Site will provide greater emphasis and availability for residents and healthcare providers of South Carolina to participate in cancer prevention and control, screening, post treatment surveillance, cancer care delivery, treatment, and imaging research studies.

PI_NAMEs: FORD, MARVELLA ELIZABETH;GRABOYES, EVAN MICHAEL;LOCKHART, ALBERT CRAIG;MARSHALL, DAVID T. (contact)

PROGRAM_OFFICER_NAME: HECKMAN-STODDARD, BRANDY

PROJECT_TERMS: Aftercare;anti-cancer research;base;Behavioral Sciences;Businesses;Cancer Burden;cancer care;Cancer Center;Cancer Control;cancer health disparity;Cancer Patient;cancer prevention;cancer type;care delivery;care providers;Caring;Catchment Area;Clinical;clinical infrastructure;Clinical Research;Clinical Trials;Collection;Communities;Community Clinical Oncology Program;Community Networks;community setting;Cultural Diversity;Data;Development;Diagnosis;dissemination science;Doctor of Philosophy;Enrollment;Ensure;Equity;ethnic diversity;ethnic minority;Ethnic Origin;Ethnic Population;evidence base;experience;geographic population;Geography;Health;Health Personnel;Health Professional;health related quality of life;Health Sciences;Healthcare;Image;imaging study;implementation science;improved;Individual;Institution;International;Intervention;Investments;Joints;Knowledge;Leadership;Malignant Neoplasms;Medical;Medical Oncology;medically underserved population;Mentors;Minority;minority health;Minority Recruitment;Mission;neoplasm registry;Oncology;operation;Outcome;Participant;Patient Outcomes Assessments;patient population;Patients;population based;population health;Positioning Attribute;preference;Prevention;programs;Protocols documentation;Provider;Psychiatry;Public Health;Race;racial diversity;racial minority;racial population;Radiation Oncology;recruit;Research;Research Infrastructure;Research Methodology;Research Personnel;Research Priority;research study;Resources;retention rate;screening;service utilization;Services;Shapes;Site;South Carolina;Survivors;Training;treatment research;underserved community;underserved minority;Universities;Vision;Work


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative Effective classification of gene variants associated with inherited retinal diseases is critical for accurate molecular diagnosis and is required to match patients to appropriate treatments to address blindness. Here we will develop disease- and gene-specific rules to modify official ACMG-AMP guidelines for variant interpretation and use these specifications to curate genomic variants found in clinical samples. This work will utilize NHGRI Clinical Genomics Resource (ClinGen) FDA approved processes, procedures, and informatics infrastructure to address seven X-linked inherited retinal disease genes including CACNA1F, CHM, OFD1, NDP, RPGR, RP2, and RS1.

PI_NAMEs: WORLEY, KIM C (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Acceleration;Address;Affect;autosome;Benign;Bioinformatics;Biological Assay;Blindness;Board Certification;Certification;Classification;Clinical;clinical diagnostics;clinical heterogeneity;Clinical Trials;clinically relevant;ClinVar;Collection;Country;Data;Dedications;Diagnosis;Diagnostic;Disabling condition;Disease;early onset;Education;Eligibility Determination;Ensure;experience;Eye diseases;FDA approved;Fright;gene therapy;gene therapy clinical trial;Gene therapy trial;gene-targeted therapy;Genes;Genetic Heterogeneity;genetic variant;genome resource;Genomics;Guidelines;improved;Individual;informatics infrastructure;Infrastructure;Inherited;Institution;Investigation;Knowledge;Laboratories;laboratory experience;Lead;Link;Maintenance;Medical;member;Modification;Molecular;Molecular Diagnosis;Mutate;Mutation;National Human Genome Research Institute;Ophthalmologist;Pathogenicity;Patients;personalized medicine;Phenotype;Physicians;Privatization;Procedures;Process;public repository;Recording of previous events;recruit;Reporting;Research;Research Personnel;Resources;Retina;Retinal Diseases;RPGR gene;Sampling;Scientist;Sorting;Specific qualifier value;Subgroup;Technology;Testing;tool;Training;translational scientist;Variant;volunteer;webinar;Work;working group;X Chromosome

PROJECT_TITLE: Integrative Curation of Clinically Relevant Variants in X-Linked Inherited Retinal Disease Genes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(50)R]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE The mission of the Bioengineering Cardiovascular Training Grant (BCTG) program at the University of Washington is to provide training that prepares our next generation of innovators in translational research that leads to improved quality of life for heart failure patients through technology and products that can be commercialized or have direct clinical application. Students receive training in research, responsible conduct of research, career development and alternatives, clinical needs, and to move ideas and research from the bench to the healthcare market.

PI_NAMEs: REGNIER, MICHAEL  (contact);ZHENG, YING

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Major Depressive Disorder;Mental Health;Mental Illness;Pediatric;Post-Traumatic Stress Disorder (PTSD);Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan. The trial will be the first fully-powered randomized trial of treatment for any psychiatric disorder following perinatal loss.

PI_NAMEs: JOHNSON, JENNIFER E (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: acceptability and feasibility;Address;African American Women;Aftercare;Bereavement;Birth;Cessation of life;Child;Child Care;Cities;Clinical;Clinical Treatment;Cognitive Therapy;Communities;Competence;Confidence Intervals;conflict resolution;coping;depressive symptoms;Distress;efficacy study;efficacy testing;Event;evidence base;experience;Family;Fetal Death;follow-up;Fright;Grief reaction;Hospitalization;Impairment;improved;improved outcome;Infant;interpersonal therapy;Intervention;Location;Major Depressive Disorder;Manuals;Mediating;meetings;Mental Depression;Mental disorders;Michigan;Minority;Moods;Mothers;National Institute of Child Health and Human Development;Neonatal Mortality;neonate;Outcome;Parents;Perinatal;peripartum depression;Personal Satisfaction;Pilot Projects;pilot trial;Population;post pregnancy;Post-Traumatic Stress Disorders;Poverty;Pregnancy;Provider;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recovery;Research;Risk;Role;Sampling;satisfaction;Schedule;single episode major depressive disorder;Sleep;social communication;social norm;Social support;Spontaneous abortion;Structure;Suicide attempt;suicide rate;Symptoms;Testing;Time;treatment as usual;United States;uptake;White Women;Woman;Women's Health;women's outcomes;Work

PROJECT_TITLE: IPT for major depression following perinatal loss

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: DA

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Drug Abuse (NIDA only);Genetics;Infertility;Neurosciences;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE  The goal of this proposal is to create an efficient new set of tools and techniques for the generation of genetically modified marmosets suitable for use as models of brain physiology and function. These studies will provide tools for future gene editing experiments in marmosets, will establish an initial set of genetically modified tool lines for use in the field, and will provide initial proof-of-principle lines for marmoset models of genetic alterations potentially relevant to the neurobiology of human brain diseases.

PI_NAMEs: HUGANIR, RICHARD L;ROSS, CHRISTOPHER A;SEGARS, JAMES H.;WANG, XIAOQIN  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: 3-Dimensional;A kinase anchoring protein;Assisted Reproductive Technology;Behavior;behavior test;Behavioral;Brain;Brain Diseases;Breeding;Callithrix;Callithrix jacchus jacchus;Caring;cell type;Cognitive;cognitive function;Communication Research;Communities;cost;Cre driver;CRISPR/Cas technology;CUL1 gene;Development;DNA cassette;Electroporation;Embryo;embryo culture;Embryo Transfer;experience;experimental study;Fertilization in Vitro;Freezing;frontal lobe;Functional disorder;Future;gene editing technology;Gene Expression;Gene Modified;gene-editing approach;Generations;Genes;Genetic;genetic manipulation;Genetic Models;genome editing;genomic locus;Germ Cells;Germ Lines;Goals;Human;improved;In Vitro;in vivo;in vivo Model;Infrastructure;male;Methods;Modeling;Modification;Molecular;Mutation;neurobiological mechanism;Neurobiology;Neurons;neuropsychiatric disorder;neuropsychiatry;Neurosciences;nonhuman primate;novel;oocyte maturation;oocyte retrieval;Ovarian Stimulations;Penetrance;Phenotype;Physiology;Population;Pregnancy;preimplantation;Preimplantation Diagnosis;Preparation;Procedures;promoter;Protocols documentation;Reporter;Research;Rodent;screening;selective expression;social;social communication;sperm cell;sperm viability;Spermatids;stem cells;Sterility;Syndrome;SYNGAP1;System;Techniques;Technology;Teratoma;Testing;Testis;Tissues;tool;Universities

PROJECT_TITLE: Tools for gene editing in marmosets


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Genetics;Methamphetamine;Prevention;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: NARRATIVE Only a subset of individuals that use drugs of abuse will develop an addiction, suggesting that the transition from drug use to dependence may be mediated by behavioral or biological factors that influence the likelihood of an individual to develop an addiction. Using computationally-derived decision-making phenotypes, this proposal seeks to identify and verify the signaling pathways that confer risk for drug use and to determine if these molecular disruptions are linked to genetic and/or environmental components of risk for drug-taking behaviors. These results will identify novel protein targets to aid in the development of more precise and direct prevention strategies for methamphetamine addiction.

PI_NAMEs: GROMAN, STEPHANIE MARY (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;addiction liability;Animals;Behavior;Behavioral;behavioral phenotyping;Bioinformatics;Biological Factors;Biological Markers;biomarker identification;Breeding;Calcium Signaling;Chronic;Computer Analysis;Cytoskeletal Modeling;Data;Decision Analysis;Decision Making;Dependence;Development;differential expression;Dissociation;Drug Exposure;drug of abuse;Drug usage;early detection biomarkers;Early identification;early life stress;Education;Environmental Risk Factor;experimental study;Exposure to;Future;Genetic;Genetic Markers;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;Goals;Human;improved;Individual;insight;interest;Learning;Link;Mediating;Mediator;Mentors;Mentorship;Methamphetamine;Methamphetamine dependence;Modeling;Molecular;motivated behavior;Neurobiology;neurotransmission;novel;novel therapeutic intervention;Nucleus Accumbens;Pathology;Pharmaceutical Preparations;Phenotype;Predisposition;Prevention;Prevention strategy;Principal Investigator;protein expression;Proteins;Proteomics;Psychiatry;Psychological reinforcement;Rattus;Research;Research Personnel;Research Proposals;Resources;Risk;Risk Marker;Role;Ryanodine Receptor Calcium Release Channel;SCA2 protein;Self Administration;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;sorting nexins;Technology;Tissues;trafficking;Training;translational potential;Universities;Variant;Viral

PROJECT_TITLE: Molecular Mechanisms of Susceptibility to Drug Use.

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Clinical Trials and Supportive Activities;Crohn's Disease;Digestive Diseases;Immunotherapy;Inflammatory Bowel Disease;Orphan Drug;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Interleukin-2 (IL-2, Proleukin®) is a T cell growth factor. IL-2 is licensed for the treatment of metastatic renal cell carcinoma and metastatic melanoma and at low doses, 100-times lower than those used in cancer therapy, IL- 2 promotes the selective expansion of regulatory T cells (Tregs) in humans. Our preliminary data in a phase 1b/2a clinical trial indicates that low-dose IL2 appears safe in ulcerative colitis patients, expands Tregs in the blood, and is associated with a biological response. In this study, we aim to assess the safety of and immune effects of low-dose IL-2 to selectively expand Tregs in vivo in patients with moderate-to-severe Crohn's disease, with the aim that this expansion will be associated with a therapeutic response.

PI_NAMEs: ALLEGRETTI, JESSICA R.;SNAPPER, SCOTT B (contact)

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: Adoptive Transfer;Affinity;Aldesleukin;analysis pipeline;anti-cancer;Autoantigens;Autologous;Biological;Biological Products;Blood;Boston;cancer therapy;CD4 Positive T Lymphocytes;Cell Count;Cell Physiology;cell type;Cells;Charge;Chronic;Chronic Disease;chronic graft versus host disease;Clinical;clinical predictors;Clinical Research;Clinical Trials;constitutive expression;Crohn's disease;CSF3 gene;Cytometry;Cytotoxic T-Lymphocytes;Data;design;Digestive System Disorders;Disease;Disease Management;Disease remission;Dose;effector T cell;experience;Failure;Food and Drug Administration Drug Approval;FOXP3 gene;Goals;graft vs host disease;Granulocyte-Macrophage Colony-Stimulating Factor;gut inflammation;Hepatitis C Therapy;high dimensionality;Homeostasis;Hospitals;Human;humanized mouse;IL17 gene;IL2 gene;IL2RA gene;Immune;Immune response;Immunomodulators;Immunophenotyping;immunoregulation;in vivo;Inflammatory Bowel Diseases;Institutional Review Boards;Insulin-Dependent Diabetes Mellitus;Integrins;Interleukin 2 Receptor;Interleukin-2;Investigational Drugs;Janus kinase;kinase inhibitor;Lactobacillus;Lamina Propria;Licensing;man;Mediating;Medical;medical schools;Metastatic Melanoma;Metastatic Renal Cell Cancer;Molecular Analysis;Monoclonal Antibody HuM291;mouse model;Mucous Membrane;murine colitis;Mus;Mutation;Natural Killer Cells;novel strategies;novel therapeutics;Oncology;Oral;Outcome;Patients;Pediatric Crohn's disease;Pediatric Hospitals;Pediatric ulcerative colitis;Peripheral;peripheral blood;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;Phase II Clinical Trials;Phenotype;Population;Positioning Attribute;pre-clinical;Predictive Factor;Predisposition;Prevalence;prevent;Proteins;Publishing;Refractory;Regulatory T-Lymphocyte;research facility;response;Safety;safety assessment;Signal Transduction;subcutaneous;Subgroup;Systemic Lupus Erythematosus;T cell therapy;T-Lymphocyte;Tacrolimus;Testing;TNF gene;transcriptomics;translational medicine;treatment response;Ulcerative Colitis;Vasculitis;Woman

PROJECT_TITLE: Low Dose Interleukin-2 for Regulatory T cell Modulation and the Treatment of Crohnâs Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-B(03)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects

ORG_CITY: PITTSBURGH

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Pain associated with trigeminal nerve injury takes a tremendous toll on those who suffer, their family and loved ones, and society because of the intensity and persistence of the pain and the absence of effective treatments. We have discovered two changes in the trigeminal nerve in response to injury that are not observed in somatic nerves in response to the same injury, and have data to suggest that these changes may not only contribute to the pain associated with trigeminal nerve injury but may serve a viable therapeutic targets as well. We have proposed to further explore the implications of these discoveries in experiments that will increase our understanding of the cause of neuropathic pain and that may suggest more effective treatment of pain associated with trigeminal nerve injury.

PI_NAMEs: GOLD, MICHAEL S (contact);SEKULA, RAYMOND F

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Action Potentials;Address;Agonist;animal data;Animal Model;Anticonvulsants;Attenuated;Axon;Behavioral;behavioral study;Cadaver;Carbamazepine;channel blockers;chronic constriction injury;Clinical;constriction;Data;density;design;Development;effective therapy;Electrophysiology (science);experimental study;Family;Female;Ganglia;Genes;Human;human tissue;Hypersensitivity;injured;Injury;knock-down;Knowledge;Light;loved ones;male;Mechanics;men;Modeling;Molecular;Multiple Sclerosis;Nerve;Nerve compression syndrome;nerve injury;Neural Conduction;new therapeutic target;novel;novel therapeutic intervention;Organ Donor;Pain;pain behavior;Pain management;pain relief;painful neuropathy;Patients;Pattern;Peripheral Nerves;Persistent pain;pharmacologic;Picrotoxin;Positioning Attribute;pre-clinical;Proteins;Rattus;receptor;response;response to injury;rho;Rodent;Role;sciatic nerve;sciatic nerve injury;SCN1A protein;SCN8A gene;Site;Societies;Spinal Ganglia;Structure of trigeminal ganglion;Suggestion;Testing;Therapeutic;Therapeutic Effect;therapeutic target;therapeutically effective;Treatment Efficacy;Trigeminal nerve structure;Trigeminal Neuralgia;Trigeminal Pain;Trigeminal System;Up-Regulation;voltage;Western Blotting;Woman

PROJECT_TITLE: Mechanisms of Pain Associated with Trigeminal Nerve Injury

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative/ Lay Summary: Skeletal deterioration and related fracture risk is exacerbated in the elderly cancer survivors receiving radiation treatment (RTx), reducing their quality of life. Our recent work shows that p21+ senescent cells and their secretome are key drivers of RTx-related skeletal deterioration. In this proposal we shall assess if acute removal of p21+ senescent cells can prevent chronic skeletal damage and initiate fracture healing.

PI_NAMEs: CHANDRA, ABHISHEK  (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Acute;Adipocytes;Adverse event;Affect;aged;Aging;AP20187;Apoptosis;Architecture;Biological Markers;Biology of Aging;biomarker identification;bone;bone cell;bone fracture repair;Bone Marrow;Bone Marrow Cells;Cancer Survivor;Caspase;CDKN2A gene;Cell Aging;cell type;Cells;chemokine;Chronic;Clinical Research;Cre-LoxP;Crossbreeding;Cyclin-Dependent Kinase Inhibitor;cytokine;Cytometry;Dasatinib;Data;Deterioration;DNA Damage;Early Intervention;Elderly;Environment;Enzymes;Excision;Fibrosis;Fracture;fracture risk;Functional disorder;functional restoration;Gene Expression;Gene Expression Profile;Generations;Genetic;Growth;Growth Factor;healing;Hematopoietic;In Situ Hybridization;Independent Living;Inflammatory;injury and repair;ITGAM gene;Knowledge;long term recovery;LOX gene;Mediating;Mesenchymal;Mouse Strains;Mus;Myeloid Cells;Nature;novel;old mice;Osteoblasts;Osteocytes;Osteogenesis;Osteoporosis;Oxidative Stress;Pathway interactions;Patients;Pattern;pharmacologic;Physiological;Plasma;Population;prevent;Proteins;Quality of life;Quercetin;Radiation;Radiation therapy;regenerative;response;Risk Reduction;RNA;Role;Seminal;senescence;senescence associated secretory phenotype;senescent cell;senolytics;skeletal;skeletal injury;stem;stressor;Stromal Cells;Testing;theories;therapeutic target;Time;Transgenes;Transgenic Mice;Visualization;Work

PROJECT_TITLE: Role of p21 positive senescent cells in radiation-induced skeletal injury and repair

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Neurosciences;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: PROJECT NARRATIVE The Xenopus model is a very powerful in vivo system, but the lack of strong complementary in vitro tools prompts researchers to rely on mammalian cell lines, which can create hurdles due to species specificities. The establishment of Xenopus laevis stem cell lines would allow the Xenopus field to benefit from more robust complementary in vitro tools, expanding the application of this model system as well as eliminating current difficulties associated with working across multiple species experimentally.

PI_NAMEs: GOUIGNARD, NADEGE  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Adult;Amphibia;Animal Cap;animal tissue;Animals;Award;Biochemical;Biological Models;Biology;blastocyst;Brain;brain tissue;cell behavior;Cell Line;Cell Separation;cell type;Cells;Cellular Morphology;Characteristics;Chick;ciliopathy;Communities;congenital heart abnormality;Defect;Development;Developmental Process;Disease;Embryo;embryo tissue;embryonic stem cell;Endocrine System Diseases;ES Cell Line;Eye;Fertilization in Vitro;Gastrointestinal Diseases;Genome;genome editing;Heart;Homologous Gene;Hour;Human;human disease;In Vitro;in vivo;in vivo Model;induced pluripotent stem cell;Inner Cell Mass;Kidney Diseases;lens;Limb structure;Malignant Neoplasms;Mammalian Cell;Methods;Modeling;Molecular;Molecular Analysis;Morphology;Mouse Cell Line;Mus;mutant;Natural regeneration;Neural Crest;Neurodevelopmental Disorder;Nobel Prize;Optic Nerve;Organ;organ growth;Organoids;orofacial;Pancreatic Diseases;Physiological;pluripotency;Population;Primary Cell Cultures;Process;programs;Research;Research Personnel;Research Project Grants;somatic cell nuclear transfer;species difference;Species Specificity;Spinal Cord;stem cell fate;stem cells;stemness;Syndrome;System;Tadpoles;Time;tissue culture;Tissues;tool;transcription factor;Transfection;Xenopus;xenopus development;Xenopus laevis

PROJECT_TITLE: Establishment of xenopus stem cell lines

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biodefense and Related Countermeasures;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE The goal of this project is to elucidate the long-term consequences of COVID-19 in the brain using advanced, quantitative imaging technology. COVID-19 survivors are at higher risk of developing neuropsychiatric and neurologic sequelae after overcoming the infection. Defining the biological basis of these persistent symptoms will be critical for developing therapies specifically targeting the underlying pathologic mechanisms associated with the long-term consequences of COVID-19 and to provide appropriate care to these individuals.

PI_NAMEs: KANTARCI, KEJAL ;OZ, GULIN  (contact);RATAI, EVA-MARIA

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Acute;Affect;Aging;Anisotropy;Antibodies;arterial spin labeling;astrogliosis;Atrophic;Autopsy;Basal Ganglia;Biochemical;Biological;Biological Markers;Biology;Biomedical Engineering;Blood;Blood Vessels;Brain;Brain Hypoxia-Ischemia;California;Caring;Central Nervous System;Central Nervous System Infections;Cerebellum;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Choline;Clinic;Clinical;clinical trial readiness;Cognitive;Cognitive deficits;cognitive function;Consensus;COVID-19;COVID-19 impact;COVID-19 sequelae;COVID-19 survivors;Data;data management;Demyelinations;Deposition;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Enrollment;Evaluation;experience;Fatigue;Functional disorder;Funding;General Hospitals;Glutamates;Glutamine;Goals;Guidelines;Headache;Hemorrhage;high risk;Hospitalization;Hypoxia;Image;Imaging technology;Individual;Infarction;Infection;Inflammatory;inflammatory marker;Injury;insight;Institution;Interleukin-1;Interleukin-6;Investigation;Iron;Ischemia;Laboratories;Lesion;Leukoencephalopathy;long term consequences of COVID-19;Long-Term Effects;Lung;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Massachusetts;Measures;Metabolic Diseases;Methodist Church;Methodology;Minnesota;multimodality;myoinositol;N-acetylaspartate;Nerve Degeneration;Neurocognitive;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neurologic;Neurologic Examination;neurologic sequelae of COVID-19;Neurologic Symptoms;neuron loss;neuropsychiatry;Neuropsychology;non-invasive imaging;Organ;pandemic disease;Parkinsonian Disorders;Participant;Pathologic;Pathology;Patients;Perfusion;Peripheral;persistent symptom;Phase;Plasma;post-COVID-19;Predisposition;prospective;Prospective Studies;quantitative imaging;Reporting;Research;Research Institute;Respiration Disorders;Respiratory Signs and Symptoms;SARS-CoV-2 infection;Site;Spectrum Analysis;Standardization;Symptoms;systemic inflammatory response;Technology;therapy development;Time;TNF gene;Underrepresented Minority;Universities;Vaccines;Vendor;White Matter Hyperintensity;World Health Organization

PROJECT_TITLE: Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Genetics;Women's Health Research

ORG_CITY: Aurora

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Invasive lobular carcinoma (ILC) is an understudied breast cancer subtype associated with poor long-term outcomes and resistance to endocrine therapy and chemotherapy, but the underlying biology of ILC is poorly understood. We identified the protein MDC1 as a unique mediator of estrogen receptor function in ILC that is critical for estrogen-driven growth, gene regulation, and anti-estrogen resistance. Understanding the role of MDC1 in ILC will provide a foundation for the development of novel therapeutic approaches and predictive biomarkers for ILC patients, a patient population in critical need of novel, ILC-specific treatment strategies.

PI_NAMEs: SIKORA, MATTHEW J (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Affect;Agonist;antagonist;Anti-estrogen Therapy;Automobile Driving;Binding;Biological Markers;Biology;cancer subtypes;Cessation of life;Chemoresistance;chemotherapy;Chromatin;Chromatin Structure;Clinical;Clinical Data;Complex;Data;Dependence;Development;Disease;DNA;DNA Binding;DNA Damage;DNA damage checkpoint;DNA Repair Gene;DNA Repair Pathway;Endocrine;Epidemiology;epigenomics;ESR1 gene;Estrogen Antagonists;Estrogen decline;Estrogen Receptors;Estrogen Therapy;Estrogens;Etiology;Foundations;Functional disorder;Gamma-H2AX;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Transcription;Genome;Goals;Growth;hormone therapy;improved;improved outcome;inhibitor;insight;knock-down;Link;Lobular Carcinoma;Malignant Breast Neoplasm;Malignant Epithelial Cell;Malignant Neoplasms;Mediating;Mediator;Modeling;next generation;novel;novel therapeutic intervention;Outcome;Patient Care;patient population;Patient-Focused Outcomes;Patients;Poly(ADP-ribose) Polymerase Inhibitor;Precision therapeutics;predictive marker;protein complex;Proteins;Proteomics;receptor function;Recurrence;Regulation;Resistance;response;Role;scaffold;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;Tamoxifen;Therapeutic;therapy resistant;transcriptome;translational study;treatment response;treatment strategy;Tumor Suppressor Proteins;Woman;Work

PROJECT_TITLE: MDC1: central regulator of estrogen receptor function and therapy response in lobular carcinoma

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Human XPD/Rad3-like helicases are critical enzymes for DNA repair and maintaining genomic stability. This project will use Escherichia coli as a model system to study the interaction between an E. coli XPD/Rad3-like helicase and single-stranded DNA binding protein to add to our knowledge of XPD/Rad3-like helicases. This foundational research will not only open doors to creating therapies for patients suffering from XPD/Rad3-like helicase genetic based diseases, but will also give insight into a novel DNA repair pathway that will have far reaching implications for the multitude of ailments caused by stalled DNA replication.

PI_NAMEs: POLLENZ, SAVANNAH WEEKS (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Affect;Affinity;analog;ATP Hydrolysis;ATP phosphohydrolase;Binding;Binding Proteins;Binding Sites;Biochemical;Biological Assay;Biological Models;Bypass;cancer risk;Cell Cycle Arrest;Cell Death;Cell Survival;Cells;Closure by clamp;Complex;Coupled;Data;Disease;Dissociation;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Polymerase III;DNA Repair;DNA Repair Enzymes;DNA Repair Pathway;DNA replication fork;DNA-Binding Proteins;ds-DNA;Environment;Equilibrium;Escherichia coli;Essential Genes;Exogenous Factors;Exposure to;Fanconi's Anemia;Fellowship;Florida;Fluorescence Resonance Energy Transfer;Genes;Genetic;Genetic Diseases;Genetic Recombination;Genome Stability;Genomic Instability;Goals;Health;helicase;Holoenzymes;Human;In Vitro;insight;Lead;Left;Lesion;Life;Location;Malignant Neoplasms;Measures;Mediating;mutant;Mutation;novel;Nucleotide Excision Repair;paralogous gene;Pathway interactions;Patients;Poison;pollutant;Predisposition;prevent;Primer Extension;Proteins;recruit;repaired;Research;Single-Stranded DNA;Site;Source;SS DNA BP;Stretching;Techniques;therapy development;Thymidine;tool;Toxin;Training;Ultraviolet Rays;Universities;Work;Xeroderma Pigmentosum;Zidovudine

PROJECT_TITLE: How SSB Regulates YoaA-chi's Function in DNA Damage Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

PHR: Project Narrative Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. Using structural and functional neuroimaging, studies of patients with cerebellar damage/degeneration, and brain stimulation methods, the experiments in this proposal will test the hypothesis that the cerebellum generates a prediction of the sequence of events involved in motor or cognitive function in order to guide behavior. This information will improve our understanding of cerebellar involvement in cognitive function, as well as cognitive abnormalities in patients with cerebellar damage or dysfunction.

PI_NAMEs: DESMOND, JOHN E (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Area;Ataxia;Behavior;Behavioral;Brain;brain behavior;Brain Stem;Cerebellar Ataxia;Cerebellum;Cognition;Cognitive;cognitive function;Corpus striatum structure;Data;Diffusion Magnetic Resonance Imaging;Digit structure;Disease;Event;Exhibits;experimental study;Functional disorder;Functional Magnetic Resonance Imaging;Genetic;gray matter;Impairment;improved;Inferior;Inferior frontal gyrus;Investigation;Language;Language Development;Learning;Left;Legal;Letters;Limb structure;Link;Measures;memory acquisition;Methods;Mind;Modeling;morphometry;Motor;motor control;Movement;neocortical;neural;neural correlate;neuroimaging;Neurons;novel;Olives - dietary;Parietal Lobe;Patients;Pattern;Performance;Phase;Probability;Prosencephalon;Psychophysiology;rehearsal;Research Personnel;Resolution;response;sensory feedback;Short-Term Memory;Source;Spinocerebellar Ataxias;statistical learning;Structure;Superior temporal gyrus;Task Performances;Telephone;Testing;Transcranial magnetic stimulation;verbal;Visualization;white matter

PROJECT_TITLE: Investigation of cerebellar involvement in cognitive sequencing

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This R25 application proposes a new research training program in the NIDDK/KUH mission areas of adult and pediatric nephrology and adult and pediatric (benign) urology. Our Nephrology and Urology training program has successfully trained fellows for careers in academics in basic, translational, and clinical research, while focused on diversity recruitment and retention. For this undergraduate initiative, we have utilized best practices from our teaching and mentoring experience for kidney scientists and leveraged the strengths of the Stanford School of Medicine to promote recruitment and success of women, underrepresented minorities, and other disadvantaged groups.

PI_NAMEs: BHALLA, VIVEK  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Agreement;Area;Basic Science;Benign;Biological Sciences;Biomedical Research;Breathing;California;career;Childhood;Clinical Research;Clinical Sciences;cohort;Communities;Data;Dedications;Department chair;design;disadvantaged background;Disparity population;diversity and inclusion;Educational process of instructing;Educational workshop;Enrollment;experience;Fellowship;Functional disorder;Funding;Future;Goals;Grant;Health;high school;Individual;Infrastructure;innovation;Institution;Intellectual Interest;interest;investigator training;Kidney;Lead;Leadership;medical schools;Medicine;Mentors;Mentorship;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Outcome;Persons;Phase;Physicians;Physiology;Population Scientist Supplement (R25);Postdoctoral Fellow;pre-doctoral;programs;Publications;recruit;Research;Research Personnel;Research Technics;Research Training;Resources;Role;San Francisco;Scientist;Siblings;Structure;Students;success;summer internship;summer research;Talents;Teacher Professional Development;Techniques;Testing;Time;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Urology;Woman

PROJECT_TITLE: The Stanford Pre-Renal Initiative: Undergraduate Training in Kidney Health

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Rare Diseases;Telehealth;Tuberculosis

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE During the COVID-19 pandemic, HIV services in sub-Saharan Africa have been adapted to lower-contact alternatives that reduce exposure to SARS-CoV-2, which maintained the effectiveness of some services but reduced the effectiveness of others. For services with reduced effectiveness, we will analyze program data to determine the extent to which effectiveness was reduced, and conduct observations and modeling to estimate the potential for SARS-CoV-2 transmission while accessing services in different ways. We will work with global, national, and local decision-makers to inform policies about when, and for whom, lower-contact services should be offered during the COVID-19 pandemic.

PI_NAMEs: BERSHTEYN, ANNA  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: 2019-nCoV;Adherence;adherence rate;Affect;Africa South of the Sahara;African;Air Movements;antiretroviral therapy;Benefits and Risks;Caring;Cause of Death;Clinic;Clinical;Collaborations;Communicable Diseases;Counseling;Country;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 risk;Crowding;Data;Decision Making;Depression screen;disability-adjusted life years;Disease;disease transmission;Effectiveness;Epidemic;Evaluation;experience;Frequencies;Guidelines;Harm Reduction;Health;health assessment;Health Benefit;HIV;HIV/AIDS;Home;Hospitalization;Human immunodeficiency virus test;improved;Infection;infection risk;Influenza;interest;Kenya;mathematical model;Mental Depression;Mental Health;Mental Health Services;mHealth;Modeling;Outcome;pandemic disease;pandemic potential;patient population;patient subsets;Patients;peer support;Performance;Persons;Policies;Population;preservation;prevent;Prevention;priority pathogen;programs;Psychotherapy;Recommendation;Research;Respiratory Disease;Respiratory Tract Infections;response;retention rate;Risk;SARS-CoV-2 exposure;SARS-CoV-2 transmission;self testing;Services;Social support;telehealth;Telephone;Teletherapy;temporal measurement;Testing;therapy adherence;Translating;transmission process;Tuberculosis;United States National Institutes of Health;Viral Load result;virtual;Visit;Work;World Health Organization;Zambia

PROJECT_TITLE: When are in-person HIV services worth the risk of COVID-19 and other communicable illnesses? Optimizing choices when virtual services are less effective

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Prevention;Rare Diseases

ORG_DEPT: SURGERY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE  Although there have been tremendous advances in cancer therapy, cancer remains a feared, disabling, and lethal disease; its prevention through the use of medications that will halt or reverse early lesions has particular promise since the complexity of changes that allow fully developed cancer to evade treatment has not yet occurred. We will conduct clinical trials to test medications that appear promising for the purposes of cancer prevention; these trials will tell us whether a particular medication is worth testing in larger trials, how it works, and who will be most likely to benefit from it. We will, in particular, focus on common cancers (breast, colon); those that are both common and lethal (lung); and those that are lethal and often fail treatment (liver, pancreas).

PI_NAMEs: KHAN, SEEMA AHSAN (contact)

PROGRAM_OFFICER_NAME: JOHNSEY, DONALD

PROJECT_TERMS: Advisory Committees;Area;Biological;Biological Markers;biomarker selection;Breast;Cancer Center Support Grant;cancer chemoprevention;cancer prevention;Cancer Prevention Trial;Cancer Science;cancer therapy;cancer type;Cities;Clinic;Clinical;Clinical Research;Clinical Trials;Collaborations;Colon;Colon Carcinoma;Communication;Comprehensive Cancer Center;Conduct Clinical Trials;Consultations;design;Development;Disabling;Disease;Dose;Drug Delivery Systems;drug repurposing;early phase clinical trial;early phase trial;Ensure;Evaluation;Fostering;Fright;Genetic Predisposition to Disease;Goals;improved;Incidence;Individual;innovation;Institution;Intervention;Investigation;Knowledge;Leadership;Lesion;Liver;Lung;Malignant Breast Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant oropharynx neoplasm;member;Mentors;Methods;Monitor;Mutation;nanoarchitecture;New Agents;novel;novel marker;Organ;Pancreas;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Physicians;Population;predictive marker;Prevention;Prevention Research;Process;programs;protocol development;recruit;reduce symptoms;Reproducibility;Research;Research Infrastructure;Research Personnel;Resources;Science;Scientist;Site;success;Sum;targeted agent;Technology;Testing;Toxic effect;Transdermal substance administration;trial design;Universities;Work

PROJECT_TITLE: Northwestern Cancer Prevention Consortium


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PUBLIC HEALTH RELEVANCE  Maternal mortality and morbidity are increasing in the U.S., prompting calls for greater action to address the rising rates and concerning racial disparities in maternal health. Native Hawaiian and Pacific Islanders (NHPIs) are profoundly underrepresented in maternal health research, despite emerging evidence of disparities. The proposed study will advance the development of data-driven and culturally-responsive interventions for NHPIs by 1) assessing critical maternal outcomes for NHPIs by maximizing the few population datasets that disaggregate NHPI and 2) characterizing NHPI experiences across several states and subgroups, and 3) identifying key factors related the processes and quality of maternity care.

PI_NAMEs: DELAFIELD, REBECCA  (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Address;Advanced Development;Area;Asian Pacific Islander;Biometry;Birth;care outcomes;career;career development;Career Mobility;Caring;Cessation of life;child bearing;Communication;Communities;community engaged research;community organizations;community partners;comorbidity;Competence;culturally appropriate intervention;Data;Data Analyses;Data Collection;Data Pooling;Data Set;Databases;Death Rate;Dedications;design;Development Plans;disparity elimination;Eclampsia;Epidemiology;ethnic minority;Ethnic Population;experience;Face;Funding;Future;Goals;Government;Grant;hands-on learning;Hawaii;Health;health care availability;health care settings;health communication;Health Disparities Research;health disparity;health inequalities;Health Personnel;Healthcare;Healthcare Systems;Hemorrhage;Hospitals;improved;Inequity;Inpatients;Insurance Coverage;Intervention;Knowledge;Language;Learning;Left;Maternal Health;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Mentored Research Scientist Development Award;Mentors;Methodology;Morbidity - disease rate;National Institute on Minority Health and Health Disparities;Native Hawaiian or Other Pacific Islander;Not Hispanic or Latino;Oregon;Outcome;Pacific Islander;patient-clinician communication;Patients;Pattern;perceived discrimination;perinatal health;person centered;Population;population health;Postpartum Period;Pregnancy;Prenatal care;Process;programs;Public Health;Quality of Care;racial disparity;racial minority;racial population;Reproductive Health;Research;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Risk Factors;severe maternal morbidity;skills;social culture;Statistical Methods;Stereotyping;Subgroup;Surveys;Testing;Training;Training Programs;Transportation;United States National Institutes of Health;Visit;Washington;White Women;Woman;Work

PROJECT_TITLE: Assessing Native Hawaiian and Pacific Islander Maternal Outcomes and Health Care Experiences


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Methamphetamine;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative: Despite the success of cART, high prevalence of HIV-associated neurocognitive disorders (HAND) poses a major challenge for the society. This proposal focuses on the use of a novel 3-dimensional organoid co-culture model to decipher mechanistic pathways that underlie abnormalities in neuronal connectivity as seen in HAND.

PI_NAMEs: JIANG, PENG ;YELAMANCHILI, SOWMYA  (contact)

PROJECT_TERMS: 3-Dimensional;Abuse Reporting;Acquired Immunodeficiency Syndrome;Address;Adolescent;Adult;Anti-Inflammatory Agents;Anti-Retroviral Agents;antiretroviral therapy;Applications Grants;Astrocytes;Autopsy;Biogenesis;Biological Assay;Biology;Blood - brain barrier anatomy;Brain;brain dysfunction;brain tissue;cell type;Cells;Central Nervous System;Cerebrum;Chronic;Clinical;Coculture Techniques;comorbidity;CRISPR/Cas technology;Data;Dendritic Spines;design;Development;Diagnosis;Disease;Drug abuse;drug of abuse;End Point Assay;Ensure;Erythro;Etiology;Event;experimental study;extracellular vesicles;Genes;genome editing;Goals;graft vs host disease;High Prevalence;HIV;HIV Genome;HIV Infections;HIV-associated neurocognitive disorder;Human;human induced pluripotent stem cells;human pluripotent stem cell;humanized mouse;in vivo;Individual;Induced Neurons;induced pluripotent stem cell;Inflammation;Inflammatory;Knowledge;Macrophage;Measures;Mediating;metabolic rate;Methamphetamine;methamphetamine abuse;Microglia;MicroRNAs;Mitochondria;Modeling;Molecular;Molecular Profiling;Monkeys;Mus;Myeloid Progenitor Cells;Nerve Degeneration;Neuroglia;Neuroimmune;neuroinflammation;Neuronal Injury;Neurons;Neuropathogenesis;neurotoxicity;non-invasive imaging;novel;novel therapeutics;Organoids;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Penetration;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;postsynaptic;presynaptic;progenitor;Property;Proteins;psychostimulant;receptor;Regimen;Reproducibility;response;Role;Sampling;self organization;Series;Signal Pathway;Signal Transduction;single-cell RNA sequencing;SIV;Societies;stem cell population;success;Synapses;synaptic pruning;Technology;therapeutic evaluation;three-dimensional modeling;tool;Toxic effect;Treatment Efficacy;Viral;Virus Diseases;Yolk Sac

PROJECT_TITLE: Cerebral organoid and IPSC derived microglia: Modeling of HIV and methamphetamine co-morbidity


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Neurosciences;Pediatric;Prevention

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Progressive retinal disease with vision loss is a chronic complication of long chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) with no current treatment and no previously established animal or cell culture models in which to test novel therapies. We have developed 2 novel experimental models and now propose experiments to characterize an in vitro model of LCHADD induced pluripotent stem cell (iPSC)-derived Retinal Pigment Epithelium (RPE)-like cells from patient specific fibroblasts and a novel LCHADD knockin mutant mouse model that exhibits decreased vision. These experiments will further our understanding of LCHADD retinal disease and provide the basis for the development of future treatments for these patients.

PI_NAMEs: GILLINGHAM, MELANIE B (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Hydroxyacyl-CoA dehydrogenase;acylcarnitine;Address;adeno-associated viral vector;Animals;Blindness;Blood;Cell Culture Techniques;Cell Differentiation Induction;cell type;Cells;Cessation of life;Child;Childhood;Chronic;Color Visions;Complication;CRISPR/Cas technology;Defect;design;Deterioration;Development;Diet therapy;Disease;Early Diagnosis;Early Intervention;Early treatment;Electroretinography;Exhibits;Experimental Models;experimental study;fatty acid oxidation;Fatty Acids;Fibroblasts;Functional disorder;Future;gene therapy;Gene Transfer;gene-targeted therapy;Genes;Genetic;Goals;Hepatic;human disease;Hydrogen Peroxide;Impairment;In Vitro;in vitro Model;induced pluripotent stem cell;Ketones;Knock-in;Light;Lipids;Liver;macula;Mediating;Metabolic;Mitochondria;Modality;Modeling;Molecular;mouse model;Mus;Muscle;mutant mouse model;Mutation;Natural History;Neonatal Screening;novel;novel therapeutics;Organ;Outcome;oxidation;oxidative damage;Oxidative Stress;Palmitates;Pathologic;Pathology;patient derived induced pluripotent stem cells;Patients;Peripheral;Phenotype;Photoreceptors;Pigments;Plasma;Point Mutation;Predisposition;preservation;prevent;Production;Protein Deficiency;Recombinant adeno-associated virus (rAAV);Recycling;response;restoration;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;Retinal gene therapy;Retinal Pigments;Role;Series;Structure;Structure of retinal pigment epithelium;Testing;Time;Toxic effect;Toxin;Vision;Visual Acuity;visual performance;VLCAD deficiency;Wild Type Mouse

PROJECT_TITLE: Exploring the pathophysiology and treatment of LCHADD retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


NIH_SPENDING_CATS: American Indian or Alaska Native;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

ORG_CITY: DULUTH

ORG_NAME: ESSENTIA INSTITUTE OF RURAL HEALTH

PHR: PROJECT NARRATIVE Enormous advances in cancer care have occurred due to NCI supported clinical trials which have resulted in substantial improvements in patient outcomes. The EHCCRP is a highly successful oncology research program that will continue to offer state-of-the-art cancer care and NCI clinical trials to patients in MN, WI, MI, ND and SD as part of the NCORP system.

PI_NAMEs: FRIDAY, BRET E.B. (contact)

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Adolescent and Young Adult;Adolescent Development;Aftercare;American College of Radiology Imaging Network;American Indian Tribe;base;Breast Cancer Detection;cancer care;cancer clinical trial;Cancer Control;Cancer Research Project;care delivery;Caring;Catchment Area;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Collaborations;Communities;Community Clinical Oncology Program;Community Health;Comprehensive Cancer Center;Eastern Cooperative Oncology Group;expectation;Fostering;Funding;Geographic Locations;Goals;Grant;Health;Health system;Hematologist;Human Resources;Image;improved;Infrastructure;Institutional Review Boards;integrated care;Malignant Neoplasms;Mammography;multidisciplinary;Names;National Cancer Institute;Native American community;next generation;Oncologist;Oncology;participant enrollment;Patient-Focused Outcomes;Patients;Pediatric Research;Prevention;programs;Protocols documentation;Research;Research Infrastructure;Rural;Rural Community;rural patients;Rural Population;screening;Site;Southwest Oncology Group;System;tomosynthesis;tribal community;tribal health;Underserved Population;Woman

PROJECT_TITLE: Essentia Health Community Cancer Research Program - NCORP


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Radiation Oncology;Rare Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE Radiation therapy for the clinical management of brain tumors and metastases is linked with severe cognitive decline and neuroinflammation in cancer survivors. We hypothesize that radiation-induced aberrant activation of the glial complement cascade play a causal role in development of cognitive impairments. This proposal will address glial complement activation mechanism and translationally feasible intervention to curtain this unmet medical need.

PI_NAMEs: ACHARYA, MUNJAL M (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Ablation;Acute;Address;Adult;Aftercare;Alzheimer's Disease;Anaphylatoxins;Animals;antagonist;Apoptotic;Astrocytes;astrogliosis;Behavior assessment;Biopsy;blood-brain barrier permeabilization;Brain;brain dysfunction;Brain Injuries;Brain Neoplasms;C5a anaphylatoxin receptor;cancer invasiveness;Cancer Survivor;cancer therapy;Cells;Chronic;Clinical;Clinical Management;clinically relevant;Cognition;Cognitive;Cognitive deficits;cognitive function;Complement;Complement 1q;complement 1q receptor;Complement 3a;Complement 5a;Complement Activation;complement system;Complex;Cranial Irradiation;cytokine;Data Set;design;Development;Dose;effectiveness testing;Epilepsy;Foundations;Gene Expression Profile;Genes;Genetic;glial activation;Glioma;Gliosis;Hour;Human;Hypertrophy;Immune signaling;Immunocompetent;Impaired cognition;Impairment;improved;Inflammation;Intervention;knock-down;Link;link protein;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Mediator;Medical;Metastatic malignant neoplasm to brain;Microglia;Molecular;mouse model;Mus;Nerve Degeneration;Neurobiology;neurogenesis;neuroinflammation;neuroprotection;neurotransmission;novel;Oral;Outcome Study;Oxidative Stress;Patients;pediatric low grade glioma;pharmacologic;Play;Production;Prognosis;Proteins;Quality of life;Radiation;Radiation therapy;receptor;Receptor Inhibition;Reporting;response;restoration;Rodent Model;Role;Signal Transduction;standard of care;stem cell proliferation;Synapses;synaptic pruning;temozolomide;Testing;Therapeutic;Therapeutic Intervention;therapy design;Tissues;TLR4 gene;Transgenic Organisms;treatment response;tumor;tumorigenic

PROJECT_TITLE: Glial immune signaling in radiation-induced brain injury

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Well-designed multicenter research is urgently needed in lung transplant to optimize donor management, improve recipient candidate selection, reduce postoperative complications, and ultimately extend long-term patient survival. The Lung Transplant Consortium (LTC) will fill these knowledge gaps through the conduct of clinical and mechanistic observational studies across up to eight Clinical Centers (CCs) and through a common protocol led by a single Data Coordinating Center (DCC). The Duke Clinical Research Institute partnered with the University of Pennsylvania as the LTC DCC will provide the consortium with outstanding scientific leadership, experienced administrative support, operational excellence, and biobanking infrastructure to ensure the development and conduct of rigorous, impactful, and efficient studies.

PI_NAMEs: CHRISTIE, JASON D;NEELY, MEGAN L;PALMER, SCOTT M (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Address;biobank;Biological;Biological Specimen Banks;Blood;candidate selection;care recipients;Case Report Form;Cells;Clinical;clinical biomarkers;clinical center;Clinical Data;Clinical Research;Clinical Trials;Cohort Studies;Collaborations;Collection;Communication;Communities;Data;Data Coordinating Center;Data Element;data management;data quality;Data Set;design;Development;digital health;Electronics;Enrollment;Ensure;experience;Faculty;Focus Groups;Funding;Genetic Markers;graft dysfunction;Home;improved;Individual;Infrastructure;innovation;Institutional Review Boards;Internet;Joints;Knowledge;Leadership;Life;Liquid substance;Longterm Follow-up;Lung;lung basal segment;lung development;Lung Diseases;Lung Transplantation;Maintenance;Manuals;meetings;Methodology;Monitor;National Heart, Lung, and Blood Institute;Observational Study;operation;Organ Transplantation;organizational structure;Outcome;Outcome Measure;Participant;patient engagement;Patient Outcomes Assessments;Patients;Peer Review;Pennsylvania;Plasma;Postoperative Complications;Postoperative Period;Preparation;prevent;Principal Investigator;Procedures;Process;prospective;Protocols documentation;Publications;pulmonary function;Regulatory Affairs;Reporting;Research;Research Institute;Research Personnel;research study;Resources;Safety;Sampling;Site;social media;sound;Specimen;Structure;success;Transplant Recipients;Transplant-Related Disorder;Transplantation;Transplantation Surgery;Transplanted Lung Complication;Universities;University resources;Update;web site

PROJECT_TITLE: Lung Transplant Consortium - Data Coordinating Center


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_NAME: ASSOCIATION OF AMERICAN MEDICAL COLLEGES

ORG_STATE: DC

PHR: Project Narrative: The Association of American Medical Colleges (AAMC) welcomes the opportunity to partner with the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) to advance our shared goal of enhancing the diversity of the biomedical research workforce. Through this funding opportunity, the AAMC will develop and deliver a multichannel educational program for cohorts of NIH-awarded K99/R00 scholars from groups underrepresented in research that provides a full suite of career development tools and supports as they transition from postdoctoral appointments into academic research faculty positions. The AAMC will richly and robustly engage the scholars in a curriculum throughout all award years that includes skills-building workshop participation, immersive activities with their local institutional and AAMC-identified mentors, and leadership and professional development conference attendance with field experts and peers nationwide.

PI_NAMEs: YELLIN, JODI  (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Advisory Committees;Affinity;American;Appointment;Association of American Medical Colleges;Award;Biomedical Research;career;career development;Career Mobility;cohort;Committee Members;Communities;Community Medicine;Dedications;design;Development;Discipline;Dissemination and Implementation;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;Education;Educational Curriculum;Educational workshop;Environment;equity, diversity, and inclusion;ethnic minority;Evaluation;Event;Evidence based program;experience;Faculty;Funding Opportunities;Future;Goals;Graduate Degree;Healthcare;Hearing;improved;Individual;innovation;Institution;Leadership;leadership development;Learning;marginalization;Medical Education;medical schools;medical specialties;Medicine;member;Mentors;Mentorship;Mission;Modeling;National Institute of General Medical Sciences;Outcome;Participant;Patient Care;peer;peer coaching;Policies;Positioning Attribute;Postdoctoral Fellow;Program Development;programs;racial minority;Research;research faculty;Research Training;Resources;Science;skills;success;symposium;Teaching Hospitals;tenure track;tool development;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Visit;Woman;Work

PROJECT_TITLE: AAMC Career Development Program for MOSAIC Scholars


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Infectious Diseases;Prevention;Topical Microbicides;Women's Health Research

ORG_CITY: MONROVIA

ORG_NAME: OAK CREST INSTITUTE OF SCIENCE

PHR: PROJECT NARRATIVE Poor adherence to HIV prevention regimens is a primary factor in lack of efficacy, with multiple, complex barriers driving product uptake and continued use. We will develop a resorbable subdermal implant for sustained systemic delivery of a novel maturation inhibitor for up to 1 year. The proposed research is relevant to public health because it will expand the development pipeline for long-acting HIV prevention products, increase understanding of the pharmacology of novel antiretroviral agents and degradable implantable delivery devices, and potentially improve device uptake, and adherence to HIV prevention regimens.

PI_NAMEs: MOSS, JOHN A (contact)

PROGRAM_OFFICER_NAME: PORTER, KRISTEN AMY

PROJECT_TERMS: Academia;Address;Adherence;AIDS prevention;Animal Model;Anti-Retroviral Agents;Area;Automobile Driving;Biodegradation;Biological Markers;Clinical;Clinical Trials;Collaborations;Complex;Coupled;Dapivirine;design;Development;Devices;Digit structure;Dose;Drug Delivery Systems;Drug Kinetics;efficacy study;emtricitabine;Evaluation;Excision;experience;fabrication;forgetting;Formulation;Frequencies;Fumarates;Generations;Goals;Histology;HIV;HIV Infections;Human;Image;Implant;implant design;improved;In Vitro;in vivo;in vivo Model;Individual;Industry;Infection;Inflammation;inhibitor;Injectable;innovation;Integrase Inhibitors;Intervention;Kinetics;Knowledge;lead candidate;Longitudinal Studies;Macaca;Macaca mulatta;Mass Spectrum Analysis;Measures;Medical;metabolomics;Methodology;Methods;Modeling;nanomolar;non-nucleoside reverse transcriptase inhibitors;nonhuman primate;novel;Nucleosides;Oral;Participant;Pharmaceutical Preparations;Pharmacodynamics;pharmacokinetics and pharmacodynamics;Pharmacology;Phase I Clinical Trials;pill;Plasma;pre-clinical;pre-exposure prophylaxis;preclinical development;Predisposition;prevent;Prevention;Process;Productivity;programs;prophylactic;Public Health;Rattus;Recording of previous events;Rectum;Regimen;Research;Resistance profile;Reverse Transcriptase Inhibitors;Risk;RNA-Directed DNA Polymerase;Route;Safety;safety study;Scientific Advances and Accomplishments;Sheep;sheep model;simian human immunodeficiency virus;subcutaneous;success;Techniques;technology platform;Tenofovir;Topical application;transmission process;truvada;ultrasound;uptake;Vagina;Vaginal Ring;Water;women versus men

PROJECT_TITLE: A Bioresorbable Subdermal Implant for Sustained Delivery of a Novel Maturation Inhibitor to Prevent HIV Infection