ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Depression;Dietary Supplements;Endocrine Disruptors;Maternal Health;Mental Health;Mental Illness;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Psychiatric disorders comprise a spectrum of mental health problems with multiple factors contributing to risk including nutrition and environmental exposures. This would be the first US epidemiological study to examine the joint associations between prenatal exposure to maternal nutrition and metals in the expression of early childhood psychiatric outcomes, specifically internalizing problems (anxiety and depressive symptoms, behavioral inhibition). As nutrition is a highly mendable factor in human health, understanding the independent and modifying effects of nutrients in the relationship between heavy metal exposures and psychiatric outcomes is arguably critical to informing early intervention.

PI_NAMEs: WRIGHT, ROSALIND J (contact);ZHANG, XUEYING

PROGRAM_OFFICER_NAME: GRAY, KIMBERLY A

PROJECT_TERMS: Address;Adolescence;Adult women;Affect;Age;All-Trans-Retinol;alpha-carotene;Antimony;Antioxidants;Anxiety;Anxiety Disorders;anxiety symptoms;Arsenic;Barium;Behavior;Behavioral;Behavioral inhibition;Biological Assay;Biological Markers;Blood;boys;Brain;Cadmium;Carotenoids;Cesium;Child;Childhood;Chromium;cohort;comorbidity;Data;Depressive disorder;depressive symptoms;Development;Diet;dietary;Dietary intake;Disease;early childhood;Early Intervention;economic cost;Ensure;environmental chemical exposure;Environmental Exposure;epidemiology study;ethnic diversity;Exposure to;fetal;Fetal Growth;Food;Frequencies;Fright;Funding;Future;girls;Health;Health Care Costs;Heavy Metals;Human;in utero;indexing;Intake;interest;intergenerational;Intervention;Iodine;Joints;Knowledge;Laboratories;Lead;Life;Ligand Binding;Link;Long term disability;Measurement;Measures;Mental disorders;Mental Health;Metal exposure;metal poisoning;Metals;Micronutrients;mother nutrition;neurobehavioral;neurodevelopment;novel;Nutrient;nutrition;Nutrition Assessment;Nutritional;offspring;Omega-6 Fatty Acids;Outcome;Outcome Measure;Oxidative Stress Pathway;Parents;Pathway interactions;Pattern;Persons;Placenta;Prefrontal Cortex;Pregnancy;Pregnant Women;prenatal;prenatal exposure;Prenatal Nutrition;Prevention;Questionnaires;racial diversity;Reporting;Research;Risk;Role;Sampling;Selenium;sex;social anxiety;Statistical Models;Stress;Symptoms;Trace Elements;urinary;Urine;Vitamin A;Woman;Work

PROJECT_TITLE: Examining Mitigating Effects of Diet on Associations among Metals and Early Childhood Psychiatric Problems

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: NS

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative A challenge in targeting the neurologic drugs to the brain is the presence of the blood-brain barrier (BBB), a dynamic structure that prevents neurotoxic blood particles and pathogens from entering the brain while simultaneously regulating bidirectional transport of nutrients and waste products. Here we seek to understanding the biological rhythms of the blood-brain barrier by establishing a human blood-brain barrier culture containing a circadian rhythm reporter. We then intend to use this model to understand the influence of inflammation on BBB rhythms and determine the timing of endogenous blood serum particles under normal and inflammatory conditions.

PI_NAMEs: ZHANG, SHIRLEY  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Affect;Apical;Astrocytes;Autoimmune;Biological Rhythm;Biology;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood Vessels;blood-brain barrier crossing;Brain;brain endothelial cell;Cell Line;Cell model;Cells;Cellular Structures;Chronic;circadian;circadian pacemaker;Circadian Rhythms;Coculture Techniques;cytokine;Data;Data Set;Dependence;Disease;Drug Delivery Systems;Drug Targeting;Enhancers;Erythrocytoses;fly;Future;Human;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;insight;knock-down;Label;Luciferases;Lupus;Mediating;Methods;Microglia;Modeling;Molecular;molecular clock;mouse model;Movement;Mus;Neurobiology;Neurologic;Neurons;neurotoxic;novel;Nutrient;particle;pathogen;Patients;Pericytes;Peripheral;Permeability;Pharmaceutical Preparations;prevent;Process;protein transport;Proteins;Regulation;Reporter;Reporter Genes;Role;Serum;Serum Proteins;Side;Structure;Supporting Cell;System;Testing;Time;Tissues;trafficking;Waste Products;Work;Xenobiotics

PROJECT_TITLE: Circadian rhythm regulation of blood-brain barrier transport and inflammation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-V (91)]


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Infectious diseases continue to have a major impact on global health and clinician-investigators play an important role in addressing infectious diseases through research whose findings can advance the development of new diagnostic, treatment, and prevention strategies. The goal of the University of Alabama at Birmingham (UAB) StARR Program is to recruit, train, and accelerate the research independence of UAB resident-investigators through mentored research, training in research methodology, and career development activities. The impact of the program will be generation of a pool of diverse resident- investigators with the knowledge, skills, experience, unique perspectives, and motivation that are all necessary to facilitate transition towards becoming the next generation of highly successful clinician- investigators who combat the burden and challenges of infectious diseases.

PI_NAMEs: GEISLER, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Acceleration;Address;Advanced Development;Advisory Committees;Alabama;Bioterrorism;Board Certification;career;career development;Clinical;cohort;combat;Communicable Diseases;Communication;Competence;COVID-19;Curiosities;Dedications;Development;Development Plans;diagnostic strategy;Diarrhea;Disease Outbreaks;diversity and inclusion;Ensure;Ethnic Origin;experience;Feedback;Funding;Future;gender diverse;Generations;global health;Goals;Grant;HIV;Immune;Immunocompromised Host;Individual;Infection;Infectious Diseases Research;innovation;Institution;interest;Internal Medicine;Investigation;Knowledge;Leadership;Malaria;Manuscripts;medical specialties;meetings;Mentors;Mentorship;Motivation;next generation;novel diagnostics;Operative Surgical Procedures;Participant;pathogen;Pathology;Pathway interactions;Pediatrics;Phase;Physicians;Play;Positioning Attribute;Post Graduate Year;Postdoctoral Fellow;Prevention strategy;Program Evaluation;programs;Publications;Publishing;Race;Readiness;recruit;Research;research and development;Research Methodology;Research Personnel;Research Training;Residencies;Resources;responsible research conduct;Role;Scheme;Science;Scientist;Series;Sexually Transmitted Diseases;skills;success;symposium;Talents;Testing;Time;Training;training opportunity;treatment strategy;Tuberculosis;Universities;Writing

PROJECT_TITLE: STIMULATING ACCESS TO INFECTIOUS DISEASES RESEARCH IN RESIDENCY (UAB StARR)

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-Z (S1)]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: FORT COLLINS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Additional Budget Narrative Data Management and Sharing Costs: $0. Equipment costs of $16,000 (-80ºC freezer) are not included in the F&A calculations for year 1. Tuition & fee costs of $13,394 are not included in the F&A calculations each year. Indirect Costs Facilities and Administrative (F&A) costs are charged according to the University’s federally negotiated rate agreement. The indirect cost rate for on-campus research is 53.5% for the period of 7/01/2023- 06/30/2024 and 54% for the period of 7/01/2024 – 08/31/2026. Year 1 Year 2 Total MTDC Base $100,085 $20,528 $111,606 F&A Rate 53.5% 54.0% 54.0% Indirect Cost $53,542 $11,085 $60,267 $124,894

PI_NAMEs: SCHOUNTZ, WILLIAM A (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: 2019-nCoV;ACE2;Agreement;American;Animal Model;Antibodies;Antibody titer measurement;Asia;Back;base;bat-borne;betacoronavirus;Bioinformatics;Budgets;California;Canada;Cattle;Central America;Cessation of life;Charge;Chiroptera;Colorado;Coronavirus;Coronavirus Infections;coronavirus pandemic;cost;Cost Sharing;COVID-19;COVID-19 susceptibility;COVID-19 vaccination;Data;data management;data sharing;Deer;Deer Mouse;Development;Disease;Domestic Animals;Equipment;Etiology;Europe;Euthanasia;Event;Facilities and Administrative Costs;Farm;Fees;Foundations;Genetic Recombination;Genome;Genotype;Human;Immune response;Immunity;Immunologics;Laboratory mice;Life;life span;Mammals;Mediation;Mesocricetus auratus;Mexico;Mink;Modeling;North America;novel;novel coronavirus;Pathogenesis;Peptide Hydrolases;Peromyscus;Phylogenetic Analysis;Population;Predisposition;Prevalence;Reporting;Research;Resistance;response;Rodent;Sampling;Sarbecovirus;SARS coronavirus;SARS-CoV-2 immunity;SARS-CoV-2 infection;SARS-CoV-2 transmission;SARS-CoV-2 variant;Serology;Seroprevalences;single-cell RNA sequencing;Site;Source;Surveys;T cell response;T-Lymphocyte;Tail;tool;United States;Universities;unvaccinated;Utah;Vaccinated;Vaccination;vaccine candidate;Vaccines;variants of concern;viral detection;Virus;Work;Zoonoses

PROJECT_TITLE: Prevalence of Coronaviruses in Wild Rodents

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 VDT-Q (01)]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This proposal aims to understand in unprecedented detail how medically-important neuromodulators, including serotonin, help generate the dynamic pattern of activity in a neural circuit. Defects in neuromodulator function appear to underlie many human brain diseases, such as mood disorders and Parkinson’s disease, yet it is difficult to understand these diseases because we as yet have little understanding of how neural circuits work. By deeply studying one neural circuit in the simple model organism C. elegans that uses the same types of neuromodulators found in the human brain, we hope to spearhead a new level of understanding of neural circuit activity that will advance our understanding of neuromodulators and their roles in brain disorders.

PI_NAMEs: COLLINS, KEVIN MICHAEL;KOELLE, MICHAEL R (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: 3-Dimensional;Animals;Area;Behavior;Biochemical;Biochemistry;Biology;Brain;Brain Diseases;Caenorhabditis elegans;cell type;Cells;cellular imaging;Chemical Synapse;conditional knockout;Coupled;Defect;Diacylglycerol Kinase;Diglycerides;Disease;egg;Electrical Synapse;Electron Microscope;Electron Microscopy;Electrophysiology (science);Escherichia coli;Event;Experimental Genetics;experimental study;Feedback;G alpha q Protein;Gap Junctions;Genetic;Goals;GTP Phosphohydrolase Activators;GTP-Binding Proteins;GTPase-Activating Proteins;Heterotrimeric GTP-Binding Proteins;Human;Human Biology;Image;imaging approach;Individual;insight;Ion Channel;Lac Operon;Lipids;Location;Maps;Measures;Mechanics;Mechanoreceptors;Mediating;Medical;Methods;model organism;Modeling;Molecular;Monomeric GTP-Binding Proteins;Mood Disorders;Muscle;Muscle Cells;mutant;Mutation;neural circuit;neural model;Neurites;Neuromodulator;Neurons;Neuropeptides;Neurotransmitters;optogenetics;Organism;Parkinson Disease;Pattern;Phospholipase;Physiological;Proteins;receptor;reconstruction;Reporter;rho;rho GTP-Binding Proteins;Role;Second Messenger Systems;Serotonin;Signal Transduction;Structure;success;System;Testing;Tight Junctions;Transgenes;Tyramine;Uterus;Work

PROJECT_TITLE: Neuromodulator signaling and activity in the C. elegans egg-laying circuit

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: KANSAS CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Effective programs for swimming and water-safety instruction for autistic children are not currently available and tremendous variability among types and techniques of swim instruction exists. This project will compare the effects of a specialized swimming and water-safety program for autistic children (Sensory Enhanced Aquatics-SEA) to standard swimming lessons, examine characteristics of instruction associated with skill attainment, and explore child, parent, and instructor perspectives about instructional methods most effective for developing swimming and water-safety among autistic children. If the project is successful, it will increase knowledge of best practice swim instruction for autistic children to potentially reduce the high risk of drowning in this population.

PI_NAMEs: MISCHE LAWSON, LISA  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Academy;Age;aged;American;Authorization documentation;autism spectrum disorder;autistic children;Behavior;Cause of Death;Characteristics;Child;Child Health;Childhood;Communities;comparative trial;Competence;Data;Diagnosis;Drowning;Educational process of instructing;Effectiveness;efficacy trial;Enrollment;evidence base;experience;Family;feasibility research;Feeling;Frequencies;Future;Goals;Guidelines;high risk;Hyperactivity;Hypersensitivity;improved;Impulsivity;inattention;Instruction;instructor;Intervention;Interview;Knowledge;Language;Learning;Methods;Monitor;Motor;motor impairment;Outcome Measure;Parents;Participant;Pediatrics;Persons;pilot trial;Population;post intervention;preference;prevent;Prevention;Prevention strategy;primary endpoint;Procedures;Program Evaluation;programs;Questionnaires;Randomized;Recommendation;Red Cross;repetitive behavior;Research;Risk;Risk Reduction;Safety;Sampling;Sensory;Severities;sex;Side;Single-Blind Study;skills;social communication;Social Interaction;Standardization;Structure;Surveys;Swimming;Teaching Method;Techniques;Testing;Training;trial comparing;United States National Institutes of Health;Visual;Water

PROJECT_TITLE: Testing Effects of Swim Instruction on Autistic Children's Swimming and Water Safety Skills

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition;Obesity;Women's Health Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: NARRATIVE There are two primary objectives in the current proposal that remain key to understanding peripheral fatty acid signaling in the taste system and, in general, the roles of various taste cell types. The first deals with the mechanistic underpinnings of Type II and Type III cells in the transduction of two classes of fatty acids – the long chain polyunsaturated fatty acids and the medium chain saturated fatty acids. The second expands from earlier research showing pronounced sex differences in fatty acid signaling and fat taste and attempts to use cell-based assays to explore the details of these differences within these cell types.

PI_NAMEs: GILBERTSON, TIMOTHY A. (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Biological Assay;Calcium;CD36 gene;Cell Physiology;cell type;Cells;comparative;Conflict (Psychology);Data;design;Desire for food;Detection;Development;Diabetes Mellitus;Diet;dietary;Dietary Fats;Disease;Eating;Elements;Endocrine system;Essential Fatty Acids;Estrus;Etiology;Exercise;Exhibits;experience;experimental study;Exploratory/Developmental Grant;Fatty acid glycerol esters;Fatty Acids;Female;Gene Expression;genetic manipulation;Goals;GPR84 gene;Health;Hormones;Image;Individual;Ingestion;Intake;Intervention;Investigation;Ions;Link;long chain fatty acid;male;mechanical signal;Mediating;Medium chain fatty acid;Minor;Modality;model organism;Modeling;Molecular;Mus;Nature;Nonesterified Fatty Acids;Nutrient;Nutritional status;Obesity;Obesity Epidemic;Ovariectomy;Overnutrition;patch clamp;Pathway interactions;Peripheral;pharmacologic;Play;Poison;Polyunsaturated Fatty Acids;Proestrus;programs;receptor;Regulation;Research;response;Role;saturated fat;Saturated Fatty Acids;Science;segregation;Sensory;sex;Sex Differences;signal processing;Signal Transduction;Specificity;STIM1 gene;Stimulus;Taste Buds;Taste Perception;taste system;Testing;TRPM5 gene;Type II Epithelial Receptor Cell;Type III Epithelial Receptor Cell;United States National Institutes of Health;Unsaturated Fatty Acids;western diet

PROJECT_TITLE: Fatty acid signaling in distinct taste cell types

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative  On average 20-30 babies born each day in the United States are born deaf or hard of hearing, where genetic causes are not always fully understood. In order to target treatments and provide better therapies, we need to understand how the auditory system functions and how these genetic mutations cause dysfunction in the system. I will apply state-of-the-art technology to investigate mechanisms related to mechanotransduction, a key step in converting sound vibrations into electrical signals sent to the brain.

PI_NAMEs: PENG, ANTHONY WEI (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TERMS: adenylate;Adenylate Cyclase;Amaze;Antibodies;Applications Grants;Auditory;Auditory system;Binding;Binding Sites;Biological Assay;Brain;Calcium;Cochlea;Coupled;Cyclic AMP;Data;deaf;deafness;Defect;Discrimination;Disease;DNA Sequence Alteration;experimental study;Frequencies;Functional disorder;G-Protein-Coupled Receptors;Genes;Genetic;genetic approach;Grant;GTP-Binding Proteins;Hair;Hair Cells;hard of hearing;hearing impairment;Human;inhibitor;insight;Kinetics;Knock-out;Knockout Mice;Lead;Ligands;Measures;mechanical properties;Mechanics;Mechanoreceptor Cell;Mechanoreceptors;mechanotransduction;Mediating;Modeling;Molecular;Monitor;Motor;mouse model;Mus;Mutant Strains Mice;Mutation;normal hearing;Pathway interactions;Pharmacology;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phospholipids;Physiological;Process;Protein Isoforms;Proteins;receptor;Regulation;Reporter;repository;response;Role;Sensory Hair;Signal Pathway;Signal Transduction;Site;sound;Source;Stimulus;System;Technology;Testing;United States;vibration;Zebrafish

PROJECT_TITLE: Molecular mechanisms of cochlear hair bundle mechanics

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Clinical Research;Infant Mortality;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Precision Medicine;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Among very preterm infants, variation in health outcomes within gestational age categories may be explained by perinatal factors. We propose to define a perinatal phenotype for very preterm infants that integrates maternal characteristics and care with infant presentation at birth to predict meaningful outcomes.

PI_NAMEs: MUKHOPADHYAY, SAGORI  (contact)

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: 5 year old;Accounting;adjudication;Affect;Antibiotics;Birth;Birth Records;burden of illness;Caring;Categories;Cesarean section;Characteristics;Child;Childhood;clinical care;Clinical Trials Design;cohort;critical period;Data Set;dysbiosis;early onset sepsis;Event;Exclusion;experience;Experimental Models;extreme prematurity;Face;Fetus;Foundations;Future;Gestational Age;Goals;Growth;Guidelines;Health;immunoregulation;improved;Individual;individualized medicine;infancy;Infant;Infection;Infection prevention;Inflammation;Inpatients;Intervention;intrapartum;late life;Life;Link;Manuals;microbial colonization;microbiome;microbiome therapeutics;Modeling;Morbidity - disease rate;mortality;Mothers;Neonatal;neonatal infection;neonate;Newborn Infant;novel;Outcome;outcome prediction;Pathway interactions;patient response;Patient Selection;Patients;Perinatal;perinatal intervention;perinatal period;Phenotype;Precision therapeutics;predictive modeling;Pregnancy;premature;Premature Birth;Premature Infant;prenatal;Prevention;Prevention trial;Probiotics;Process;Randomized;Records;Regimen;Registries;response;Retrospective cohort;Risk;Risk Factors;risk stratification;Severity of illness;sobriety;statistics;System;systemic inflammatory response;Techniques;Testing;Therapeutic;Time;Translations;trial design;United States;Variant;Weight Gain;Work

PROJECT_TITLE: Early Life Phenotyping of Very Preterm Infants

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Primary Immunodeficiencies;Rare Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE: Somatic hypermutation (SHM) is essential for B cells to evolve high-affinity antibodies against pathogens and vaccine immunogens and deficit SHM is associated with human immunodeficiencies. We find that Uracil-DNA glycosylase (UNG) mutants unable to interact with replication protein A (RPA) impair mutation events in vitro. The goal of this application is to develop a mouse model to understand the mechanistic contribution of RPA- UNG interaction to SHM in vivo.

PI_NAMEs: MCBRIDE, KEVIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: activation-induced cytidine deaminase;Address;Affinity;Animal Model;Antibodies;Antibody Affinity;Antigens;Autoantibodies;Autoimmunity;B-Cell Development;B-Lymphocytes;Base Excision Repairs;Binding;Binding Proteins;Biological Assay;Cell Line;Cell model;chronic infection;Clustered Regularly Interspaced Short Palindromic Repeats;congenital immunodeficiency;CRISPR/Cas technology;Cytidine;Cytosine;Data;Deamination;Defect;Development;DNA biosynthesis;DNA Repair;Event;Excision;Follow-Up Studies;Frequencies;gene editing technology;Generations;Genetic study;genome integrity;Goals;homologous recombination;Human;Hyperimmunoglobulin M Syndrome;IgE;Immune response;immunodeficiency;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin Genes;Immunoglobulin M;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;Immunoglobulins;Impairment;In Vitro;in vitro Model;in vivo;Induced Mutation;Infection;Innate Immune Response;Knock-in Mouse;Knockout Mice;Literature;Lymphocyte;lymphoid structures;Mediating;Modeling;mouse model;Mus;Mutagenesis;mutant;Mutation;Mutation Spectra;Outcome;pathogen;Pathway interactions;Patients;Phenotype;Point Mutation;Process;Protein Binding Domain;Proteins;Recurrence;recurrent infection;Regulation;repair enzyme;repaired;replication factor A;Reporter;Reporting;Role;Structure of germinal center of lymph node;System;Technology;tool;transversion mutation;Uracil;uracil-DNA glycosylase;Vaccines;Variant;Viral Pathogenesis;Wild Type Mouse

PROJECT_TITLE: A somatic hypermutation defective UNG mutant in antibody deficiency through destabilization of RPA interaction.

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Patient Safety

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative As growing millions of older adults with frailty, Alzheimer’s Disease and related dementias, multimorbidity and serious illness undergo surgery, significant knowledge gaps remain as how to best care for them and achieve optimal outcomes. Rigorous research training is required to prepare the next generation of surgeon-scientists to take on the clinical, research, and policy challenges ahead, however there are no training programs specifically designed to give surgical residents, including those from under-represented minority groups, necessary skills to conduct high-quality research related to fundamental questions in surgery and aging. We propose the Mentored Research Training in Aging and Surgery (MERITAS) Program based at the Center for Surgery and Public Health (CSPH) at Brigham and Women’s Hospital (BWH) to provide two dedicated years of mentorship and skill development conducting health services research at the intersection of surgery and launch a community of 8 diverse surgeons for productive research careers.

PI_NAMEs: COOPER, ZARA R (contact);NGUYEN, LOUIS LOC

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Address;Admission activity;Aging;Alzheimer's disease related dementia;Ambulatory Surgical Procedures;American;Area;Black race;Boston;Budgets;Capsicum;care delivery;career;caregiving;Caring;Clinical;clinical care;clinical training;cohort;Communities;cost;Death Rate;Dedications;design;disability;Discipline;Education;Epidemiology;Ethnic Origin;Ethnic Population;Excision;experience;Face;frailty;Funding;Future;Future Generations;General Population;Geography;Geriatrics;Goals;graduate school;Grant;Health;health care service utilization;Health Policy;Health Services;Health Services Research;Historically Black Colleges and Universities;Home;Hospitals;improved;innovation;inpatient surgery;insight;Investigation;Knowledge;Leadership;Life Expectancy;Longevity;Malignant Neoplasms;Medical;medical schools;Medicine;meetings;member;Mentors;Mentorship;Methodology;Minority Groups;multidisciplinary;multiple chronic conditions;next generation;older adult;older patient;operation;Operative Surgical Procedures;Outcome;Patient Care;Patients;people of color;Personal Satisfaction;Physicians;Policies;post-doctoral training;pressure;Prevalence;Process;Productivity;programs;Public Health;Public Health Schools;Race;racial population;recruit;Research;Research Personnel;Research Support;Research Training;Residencies;Resources;Risk;Scientist;Secure;skill acquisition;skills;Structure;Surgeon;surgical research;Surveys;Time;Training;Training and Infrastructure;Training Programs;Trauma;Traumatic injury;Travel;trend;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Wages;Woman

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-I (O2)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Columbus

ORG_DEPT: PSYCHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE There is a dire need to systematically develop, refine, and examine for efficacy promising behavioral interventions that can be easily disseminated to aging adults at-risk for AD and related dementias. The research proposed in the current application will systematically develop and test the feasibility of an internet-based, asynchronous, mindfulness program (iMBSR) with a matched control group for adults with subjective cognitive decline. This Stage I study, yielding estimates on successful recruitment, adherence, adverse events, overall acceptability, and effect sizes for mind-wandering, and plasma-based AD biomarkers of Aβ and tau will provide important foundational data for future efficacy trials of the iMBSR program.

PI_NAMEs: PRAKASH, RUCHIKA SHAURYA (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: acceptability and feasibility;active control group;Adherence;Adult;Adverse event;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Attention;attentional control;Awareness;Behavior Therapy;Behavioral;Biological Markers;Clinic;Clinical Trials;Cognitive;cognitive function;Collaborations;Computers;Control Groups;cost estimate;Data;Dementia;dementia risk;design;Deterioration;Development;Distance Education;E-learning;Education;Educational process of instructing;efficacy evaluation;efficacy testing;efficacy trial;Elements;evidence base;executive function;Feasibility Studies;feasibility testing;Focus Groups;Functional disorder;Future;Goals;gray matter;group intervention;high risk;Hippocampus;Impaired cognition;Individual;Instruction;interest;Internet;Intervention;intervention effect;Life;Life Style;Link;Liquid substance;Measures;Medical;Memory Disorders;middle age;Mind;mindfulness;mindfulness meditation;Mindfulness Training;mindfulness-based stress reduction;Minority Groups;Nerve Degeneration;neural;neural circuit;neuroimaging;older adult;Participant;Pathology;peer support;Persons;Phase;Pilot Projects;Placebo Control;Plasma;post intervention;pre-clinical;Prevalence;Prevention Research;preventive intervention;Primary Prevention;Process;programs;prospective;Protocols documentation;Psychologist;Public Health;recruit;Research;Sampling;satisfaction;Services;societal costs;Specialist;success;tau Proteins;Tauopathies;Techniques;Temporal Lobe;Testing;Thinness;Training;Training Programs;United States;web platform;Work;β-amyloid burden

PROJECT_TITLE: Development of an online mindfulness training program for adults with subjective cognitive decline

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: HL

ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: The “Purposeful Outreach for Diversity and Inclusion of Underrepresented in Medicine (PODIUM) Physician- Scientists” T32 training program will provide advanced research training in heart, lung, blood and sleep (HLBS) disorders to underrepresented in medicine (URM) postdoctoral trainees from established, senior investigators at Einstein-Montefiore. The PODIUM leadership team will implement an individualized curriculum for each trainee with structured classwork, seminars and workshops to supplement the hands-on research with mentors and transition to academic careers. The ultimate goal of the PODIUM T32 program is to provide the next generation of URM investigators with the state-of-the art experiences and skills required to initiate and sustain successful independent careers in HLBS research.

PI_NAMEs: ISASI, CARMEN R.;REZNIK, MARINA  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TITLE: Purposeful Outreach for Diversity and Inclusion of Underrepresented in Medicine (PODIUM) Physician-Scientists

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-Z (O2)]


ORG_CITY: CHARLOTTE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NORTH CAROLINA CHARLOTTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE Bone disorders resulting from bacterial infection are associated with severe inflammation and bone loss, but the mechanisms regulating such damage are poorly understood. While type I interferons are increasingly recognized to impact host susceptibility to bacterial pathogens and have been shown to affect bone homeostasis, their role in staphylococcal bone infections has not been examined. In this pilot study, we will begin to determine whether type I interferons serve a protective role in bone infections by limiting the ability of bacteria to survive in local cells and/or by reducing the number and activity of bone resorbing cells.

PI_NAMEs: MARRIOTT, IAN  (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Affect;Agonist;Antibiotics;autocrine;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Biological Response Modifiers;bone;bone cell;Bone Diseases;bone loss;Bone remodeling;bone resorbing activity;Bone Resorption;Bone Tissue;Cell Culture Techniques;Cell Separation;Cells;Chemotactic Factors;Chronic;Clinical;cytokine;Cytoplasm;Data;Diagnosis;Future;Genes;Genus staphylococcus;Homeostasis;Immune response;improved;Incidence;Infection;Inflammation;Inflammation Mediators;Inflammatory;inflammatory bone loss;inhibitor;Interferon alpha;Interferon Type I;Interferon-beta;Interferons;Invaded;Leukocytes;Mediating;Mediator;Microbial Biofilms;Mus;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteocytes;osteogenic;Osteolytic;Osteomyelitis;paracrine;pathogenic bacteria;Pilot Projects;Play;Predisposition;Production;Prophylactic treatment;recruit;Recurrence;recurrent infection;Refractory;Regulation;Reporting;Research Project Grants;response;Role;sensor;Severities;Site;Source;Staphylococcal Infections;Staphylococcus aureus;Staphylococcus aureus infection;Testing;TLR3 gene;TNFSF11 gene;treatment strategy;Viral

PROJECT_TITLE: Type I interferon responses of bone cells to Staphylococcus aureus: A pilot study

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ORG_CITY: CHICAGO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative After an initial minor stroke, the risk of another stroke occurring is high, particularly in the first days and weeks, and then falls to a lower rate that is steady over time. This change over time in rates of recurrence of stroke can be understood as a transition after stroke from a vulnerable state to a stabilized state, with the different mechanisms of stroke in the two states potentially targeted by different preventative medicines. Combining large data sets from clinical trials that have included patients starting immediately after the initial stroke will provide the opportunity to detect which risk factors or medications affect each of the distinct rates that determine stroke recurrences over time.

PI_NAMEs: BRORSON, JAMES R. (contact)

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: active method;Acute;acute stroke;Affect;Anti-Inflammatory Agents;Biological;Blood Platelets;Blood Pressure;Cephalic;Characteristics;Cholesterol;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Design;Colchicine;Common Data Element;Data;data dictionary;Data Element;data harmonization;Data Set;data standards;Databases;design;Diabetes Mellitus;Disease;Disease-Free Survival;efficacy outcomes;Event;experience;falls;follow-up;Future;Goals;indexing;Individual;insight;interest;Intervention;intracranial artery;Intracranial Atherosclerotic Disease;Ischemia;Ischemic Stroke;kinetic model;Kinetics;large datasets;Maps;Mathematics;Medicine;Minor;Modeling;Outcome Measure;Patient risk;Patients;Pharmaceutical Preparations;Phase;post stroke;predictive modeling;prevent;Prevention trial;Preventive Medicine;Process;radiological imaging;Randomized;Recovery;Recurrence;Regression Analysis;Research;response;Risk;Risk Factors;safety outcomes;secondary analysis;Secondary Prevention;Smoking Status;Standardization;Statistical Data Interpretation;Statistical Models;Stenosis;Stroke;stroke model;stroke patient;Stroke prevention;stroke risk;Structure;Testing;therapeutic development;Therapeutic Intervention;Time;Transient Ischemic Attack;trial design

PROJECT_TITLE: Kinetic analysis of acute stroke secondary prevention trials: Insights from combined datasets guiding future trial design

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-S (15)]


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_NAME: NEW YORK CITY HEALTH/MENTAL HYGIENE

PHR: Component A: Core Surveillance Project Narrative The New York City Pregnancy Risk Assessment Monitoring System will provide population-based surveillance data of high scientific quality on maternal attitudes, experiences, and behaviors before and during pregnancy as well as early infancy. These data are not available from any other source and thus are important for developing and evaluating programs and policies aimed at improving maternal and infant health in New York City. The data will also serve to monitor progress towards select national Healthy People 2030 indicators.

PI_NAMEs: SEARING, HANNAH  (contact)

PROJECT_TITLE: Component A: New York City Pregnancy Risk Assessment Monitoring System, a surveillance system of maternal experiences and behaviors around the time of pregnancy to inform local programs and policies


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Tuberculosis (TB), caused by the human pathogen Mycobacterium tuberculosis (Mtb), is the second leading infectious disease killer in the world. Despite this global importance and an increasingly drug-resistant Mtb, new approaches to diagnosis and treatment are limited by a lack of human experimental systems to identify key determinants of the outcome of infection. Here, we introduce and necessarily employ a tissue engineered biomimetic model of human TB granuloma for the identification and testing of new therapeutics for the control of human TB.

PI_NAMEs: ERNST, JOEL D.;KUTYS, MATTHEW L (contact)

PROGRAM_OFFICER_NAME: ROBINSON, RICHARD THOMAS

PROJECT_TERMS: 2019-nCoV;3-Dimensional;Address;Adopted;Alveolar Macrophages;Animal Model;Architecture;B-Lymphocytes;Bacteria;Behavior;Behavioral;Binding;Biological;Biological Markers;Biomimetics;Blood;Blood Vessels;Cell Culture Techniques;cell dimension;Cell Physiology;Cell secretion;Cell Survival;cell type;Cells;Cessation of life;Characteristics;chronic infection;Communicable Diseases;Complex;Confocal Microscopy;Containment;Dendritic Cells;Deposition;Development;Diagnosis;Disease;Disease Outcome;Drug resistant Mycobacteria Tuberculosis;Elements;Endothelium;Engineering;Environmental Risk Factor;Event;Experimental Models;Extracellular Matrix;Failure;Fibroblasts;Foundations;Generations;Genus Mycobacterium;Granuloma;Growth;high throughput screening;Homing;Human;Human Biology;human model;human pathogen;Immune response;Immunity;improved;Individual;Infection;insight;Intervention;Knowledge;Lesion;live cell imaging;Location;Lung;Lymphocyte;Macrophage;Maintenance;Mediating;Modeling;Molecular;monocyte;Mononuclear;Morphogenesis;mycobacterial;Mycobacterium tuberculosis;novel;novel strategies;novel therapeutics;Outcome;pathogen;Pathogenesis;Perfusion;Peripheral;Peripheral Blood Mononuclear Cell;Persons;Phagocytes;Phenotype;Population;pre-clinical;Prevention;Process;process optimization;Production;Quantitative Microscopy;rational design;recruit;Research;response;self assembly;Signal Transduction;Site;spatial relationship;Specificity;Structure;Structure of parenchyma of lung;System;Testing;three-dimensional modeling;Tissue Engineering;Tissue Expansion;Tissues;transmission process;Tuberculosis;tuberculosis granuloma;tuberculosis immunity;tuberculosis treatment;ultra high resolution;Vascular Endothelium;Vascularization

PROJECT_TITLE: 3D biomimetic human tuberculosis granulomas to identify novel host-pathogen interactions


NIH_SPENDING_CATS: Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: RELEVANCE DDX RNA helicases or ATPases are involved in virtually every RNA metabolism step, from ribosome biogenesis to transcription, RNA maturation, microRNA processing, translation, and RNA degradation. This project will unravel the underlying mechanisms of the nucleolar specific RNA helicase DDX18 in controlling nucleolar integrity for pluripotency of human embryonic stem cells, establishing a novel paradigm for cell fate control and providing insights into developing therapeutics targeting the nucleolar dysfunction in human diseases such as ribosomopathies.

PI_NAMEs: WANG, JIANLONG  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: 3-Dimensional;Aging;Architecture;ATP phosphohydrolase;Binding;Biogenesis;biophysical properties;Biophysics;C-terminal;Cell Differentiation process;Cell Fate Control;Cell Nucleolus;Cell Nucleus;Cells;Centromere;Chromatin;Chromatin Structure;cofactor;Communities;Complex;Coupled;Cytoplasm;Data;derepression;Development;Disease;embryonic stem cell;Family member;Functional disorder;Gene Cluster;Gene Expression;Genes;Genetic Transcription;Genome;Genome Stability;Goals;Hela Cells;helicase;Heterochromatin;Human;human disease;human embryonic stem cell;human stem cells;Impairment;insight;Knowledge;Liquid substance;Maintenance;Malignant Neoplasms;Maps;Mediating;Membrane;MicroRNAs;Molecular;Mus;new technology;novel;NPM1 gene;Nuclear;Nucleic Acids;Nucleolar Proteins;Nucleoplasm;Organelles;Outcome;Phase;Physical condensation;Physical Function;pluripotency;Pluripotent Stem Cells;Property;Protein Family;Proteins;Proteomics;Recording of previous events;Regulation;Reporting;Research;Ribonucleoproteins;Ribosomal DNA;Ribosomal RNA;Ribosomes;ribosomopathy;RNA;RNA Binding;RNA Degradation;RNA Helicase;RNA interference screen;RNA metabolism;RNA Polymerase I;Role;Shapes;Small Nucleolar RNA;stem cell differentiation;Stem cell pluripotency;stem cells;Structure;Testing;Therapeutic;therapeutic target;tool;trait;transcription factor;Translations;virtual;Work

PROJECT_TITLE: A Nucleolar Paradigm for Pluripotency of Human Embryonic Stem Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-B (02)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed research is relevant to public health because it will profile and define the antiviral potential of transfer RNA fragments made during gammaherpesvirus infection. This work will establish transfer RNA fragment functionality during gammaherpesvirus infection and the antiviral response, while also contributing a widely-applicable and innovative sequencing strategy to accurately profile transfer RNA fragment expression. Thus, the proposed research is relevant to part of NIAID’s mission that pertains to enhancing our understanding and treating infectious disease.

PI_NAMEs: TUCKER, JESSICA MITCHELL (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Anti-viral Agents;Anti-viral Response;Automobile Driving;Bacteria;Bacterial Infections;Binding;Binding Proteins;Biochemical;Biogenesis;Bone Marrow;cell type;Cells;combat;Communicable Diseases;Data;deep sequencing;DNA Virus Infections;endonuclease;Event;experimental study;Fibroblasts;gammaherpesvirus;Gene Expression;Genes;Genetic;Goals;Immune response;Immunocompetent;in vivo;Infection;innovation;Knowledge;Macrophage;Measures;Mediating;Mission;Molecular;National Institute of Allergy and Infectious Disease;Nature;novel;Oncogenic;Outcome;premature;prevent;Production;Public Health;Publishing;Reporting;Research;response;Ribosomes;RNA Polymerase III;RNA Viruses;RNA-Binding Proteins;Role;screening;Structure;Techniques;Testing;Therapeutic;tool;Transfer RNA;Translational Repression;Up-Regulation;Viral;Viral Physiology;Virus;Virus Diseases;Virus Replication;Visualization;Work

PROJECT_TITLE: Gammaherpesviruses induce transfer RNA cleavage

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Dementia;Estrogen;Neurodegenerative;Neurosciences;Precision Medicine;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Co-occurring small vessel disease (SVD) in the brain accelerates the progression of Alzheimer’s disease (AD). Older women have a greater SVD-related AD risk. In this study, using state-of-the-art MR imaging, we will test whether women have faster progression of SVD than men. We also evaluate the treatment effects of Equol, an oral supplement, on brain SVD. Targeting SVD with an intervention is particularly promising for reducing AD risk in women.

PI_NAMEs: AIZENSTEIN, HOWARD J;SEKIKAWA, AKIRA ;WU, MINJIE  (contact);YANG, SHAOLIN

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Acceleration;Age;age related;age related changes;Aging;aging biomarker;aging brain;aging process;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid beta-Protein;Angiography;Antiinflammatory Effect;Antioxidants;arterial stiffness;Arteries;Atrophic;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier function;Brain;cardiovascular risk factor;Cerebral small vessel disease;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Cerebrovascular system;Cerebrum;Chronology;Clinical;clinical effect;Clinical Markers;Cognition;daidzein;Data;Dementia;Discrimination;Disease Outcome;Disease Progression;disorder prevention;Disproportionately impacts women;Elderly;Epidemiology;equol;estrogenic;Extravasation;Funding;Glutamates;Gonadal Steroid Hormones;gray matter;gut microbiome;Heart;Heterogeneity;Image;imaging biomarker;Impaired cognition;improved;Individual;Inflammation;Infrastructure;Intervention;Intervention Studies;Isoflavones;machine learning algorithm;machine learning model;Magnetic Resonance Imaging;magnetic resonance spectroscopic imaging;Measures;men;Mental Depression;Methods;Microvascular Dysfunction;Modeling;Molecular;molecular imaging;molecular marker;Morphology;myoinositol;N-acetylaspartate;neurochemistry;Neuroglia;Neurons;novel;older adult;older women;oral supplementation;Parents;Pathology;Pathway interactions;Pattern;Placebos;Population;Postmenopause;Precision therapeutics;Predisposition;Risk Factors;Role;sex;Sex Differences;Site;sleep quality;Structure;tau Proteins;Testing;therapeutic target;Time;Training;treatment effect;treatment group;treatment strategy;Veins;white matter;White Matter Hyperintensity;Woman;young man

PROJECT_TITLE: 7T Vascular and Molecular Imaging of SVD: Sex, Equol, and Risk of Alzheimer’s Disease

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

PHR: Narrative We seek to reveal sex differences in an engineered microfluidic cardiac hypertrophy-on-a-chip platform populated with sex-specific cardiac cells. It is hypothesized that there exist critical differences between sexes in the development of biomechanically induced and/or biochemically induced cardiac hypertrophy in the biomimetic on-chip platform. Sex as an important biological variable in heart-on-a-chip systems has not been investigated so far and we envision our high-risk, high-reward bold new method project to lay down the basis for future in-depth studies on this indispensable but highly underrepresented parameter.

PI_NAMEs: MAHARJAN, SUSHILA ;ZHANG, Y. SHRIKE  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: Age;Animals;Basic Science;Biochemical;Biological;biological sex;Biomechanics;Biomedical Research;Biomimetics;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Cause of Death;Cells;Cessation of life;clinical application;Clinical Research;Clinical Trials;Complex;Development;Devices;diagnostic strategy;Dimensions;Disease;Disparity;Endothelial Cells;Engineering;epidemiology study;Etiology;experience;Extracellular Matrix;Female;Fibroblasts;Functional disorder;Future;Gene Expression;Germ Cells;Goals;Gonadal Steroid Hormones;Heart;Heart Diseases;Heart failure;heart function;Heart Hypertrophy;Hematological Disease;high reward;high risk;Hormones;Human;human induced pluripotent stem cells;Hydrogels;Hypertrophy;improved;In Vitro;Incidence;induced pluripotent stem cell derived cardiomyocytes;insight;Intraventricular;Investigation;Length;Link;male;Malignant Neoplasms;man;mechanical stimulus;Mechanical Stress;Mechanics;men;Menstrual cycle;Metabolic syndrome;Methods;Microfluidics;Modeling;Molecular;Morphology;mortality;Myocardial;Myocardial Infarction;Organ;organ on a chip;Participant;Pathogenesis;Pathologic;Pathology;Patients;Performance;Periodicity;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phenotype;Physiological;Physiology;Play;Postmenopause;Premenopause;pressure;Prevalence;Prevention strategy;Prognosis;Relaxation;Reporting;Research;response;Risk Factors;Role;Scheme;sex;sex as a biological variable;Sex Differences;Signal Transduction;Stimulus;Stress;System;Thick;Tissues;treatment strategy;United States;Ventricular;Ventricular Remodeling;Woman;Women's mortality

PROJECT_TITLE: Modeling Sex-Specific Cardiac Hypertrophy-on-a-Chip

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ADMINISTERING_IC: EY

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: NARRATIVE Fuchs’ dystrophy is characterized by the destruction of the corneal endothelium due to genetic defects and is currently treatable only by corneal transplantation. As there are currently no models to study this disease, we will develop animal models of late-onset Fuchs’ dystrophy (the most common form). These animal models will enable research into the causes and treatments for late-onset Fuchs’ dystrophy.

PI_NAMEs: UEHARA, HIRONORI  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Adenoviruses;Age Years;Animal Model;Animals;anterior chamber;base;Blindness;Breeding;Caucasians;Cell Density;Cell Nucleus;Cell Physiology;Collagen;Confocal Microscopy;Cornea;Corneal Diseases;Corneal edema;Corneal Endothelium;Corneal Opacity;Country;Descemet's membrane;Developed Countries;Development;Disease;DNA;DNA Sequence Alteration;Electron Microscope;Endothelial Cells;Endothelium;Enterobacteria phage P1 Cre recombinase;Event;Fuchs' Endothelial Dystrophy;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;genomic locus;Genomics;Graft Survival;Hereditary Disease;High Prevalence;Human;In Situ Hybridization;In Vitro;in vivo;in vivo monitoring;Inherited;Injections;Introns;Ions;Keratoplasty;Lead;Length;Liquid substance;Measurement;Medical;Mental disorders;Microscope;Modeling;mouse model;mRNA Expression;Mus;Mutation;Myotonic Dystrophy;Myotonic dystrophy type 1;Neuron-Specific Enolase;novel therapeutics;Nucleotides;Optical Coherence Tomography;Osmosis;Other Genetics;overexpression;Pathogenesis;Pathogenicity;Pathologic;Patients;PF4 Gene;pharmacologic;Phenotype;Plasma;Population;postmitotic;Prevalence;Prevention;promoter;Pump;Reporting;Research;RNA;RNA Splicing;Scanning;Stains;Stress;Structure;Testing;Tetracyclines;therapeutic development;therapy development;Thick;Trans-Activators;Transcription Alteration;transcription factor;Trinucleotide Repeats;Untranslated Regions;Virus;Vision

PROJECT_TITLE: New animal model for late-onset Fuchs endothelial corneal dystrophy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: SAINT LOUIS

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE We will develop a vectored immunotherapy approach for HIV by means of in vivo modification of B cells to express anti-HIV antibodies. To feasibilize this approach we will develop adenoviral vectors capable of efficient and selective transduction of target B cells in vivo.

PI_NAMEs: CURIEL, DAVID TERRY (contact);FARZAN, MICHAEL R.;MARTINS, MAURICIO DE AGUIAR

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: Activities of Daily Living;Address;Adenovirus Vector;Adenoviruses;Adoptive Transfer;Affinity;Antibodies;Antibody Response;Antibody titer measurement;Antigen Receptors;Antigens;B-Lymphocytes;Biological Models;Cells;cellular engineering;cellular transduction;CRISPR/Cas technology;defective adenoviral vector;Derivation procedure;design;Development;DNA;Effector Cell;Engineering;Evaluation;Funding;Gene Delivery;gene therapy;Genes;Genetic;Genetic Engineering;Genome;HIV;HIV Antibodies;HIV Antigens;Human;Immune;Immune system;Immunoglobulin Class Switching;Immunotherapy;improved;In Situ;in vivo;Infection;Investments;Knock-in;Mature B-Lymphocyte;Mediating;Memory;Methodology;Methods;Modeling;Modification;Mus;neutralizing antibody;nonhuman primate;novel;novel strategies;Production;repaired;Resistance;response;RNA Splicing;Running;Safety;Self Tolerance;Technology;Therapeutic;United States National Institutes of Health;Vaccination;Vaccine Antigen;vector;Viral Antigens;Viral reservoir;Work

PROJECT_TITLE: Vectored HIV Immunotherapy via in vivo B cell editing

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 BJM-A (S1)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Project Narrative After mating, when sperm enter the uterus, they are attacked by the female’s immune system but a few move quickly into the oviduct where they survive for a longer period and form a storage reservoir. Their enhanced survival in the oviduct is partly because they do not trigger a phagocytic response. We have discovered that sperm have sugars on their surface that bind to receptors in the oviduct and we will determine if this system helps retain sperm in the reservoir and dampen the phagocytic response.

PI_NAMEs: ANTONSON, ADRIENNE M;MILLER, DAVID JOEL (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Acetylgalactosamine;Adhesions;Affect;Affinity;Binding;Biological Response Modifiers;Cell Adhesion;Cell Nucleus;Cell Separation;Cell surface;Cells;Cervical;chemokine;Chemotaxis;cytokine;Deposition;Docking;Embryo;Epithelial Cells;Epithelium;experimental study;extracellular;Family suidae;Female;female reproductive system;Fertility;Flow Cytometry;Gene Expression;Hour;Immune;Immune response;Immune system;Immunofluorescence Immunologic;Immunoglobulins;Immunologics;Immunosuppression;In Vitro;in vivo;Individual;Infertility;Infiltration;Inflammation Mediators;Inflammatory;Innate Immune Response;Insemination;Intracellular Signaling Proteins;Invaded;Investigation;ITIM;Kidney;Lectin;Leukocytes;life span;Ligands;Macrophage;Mammalian Oviducts;Masks;Modeling;Natural Immunity;neutrophil;NR0B2 gene;Oligosaccharides;Organ;Partner in relationship;pathogen;Phagocytes;Phagocytosis;Polysaccharides;preference;Production;Prostate;Proteins;PTPN11 gene;Reaction;receptor;response;Role;Seminal fluid;sialic acid binding Ig-like lectin;Sialic Acids;sialylation;Signal Transduction;Signaling Protein;Site;sperm cell;sugar;Surface;System;Testing;therapy development;Time;Tissues;transcriptome sequencing;TYROBP gene;Uterus

PROJECT_TITLE: Oviduct Siglecs: Role in the Sperm Immune Response

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Aging;Complementary and Integrative Health;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dietary Supplements;Emerging Infectious Diseases;Infectious Diseases;Neurodegenerative;Nutrition;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE (Public Health Relevance) Oxidative stress (OxS) is a biochemical process that leads to damage of cellular lipids and is associated with the pathophysiology of aging and numerous human diseases, including cardiovascular disease, neurodegeneration, frailty, and SARS-CoV-2 (COVID-19). We propose to study how certain oxidized lipids are broken down in the body. Establishing precise methods to ensure the complete quantification of these compounds and their metabolites will help to clarify the role OxS – and potential therapies – in health and human disease.

PI_NAMEs: MILNE, GINGER LOHR (contact)

PROGRAM_OFFICER_NAME: FU, YI-PING

PROJECT_TERMS: 2019-nCoV;Acids;Address;adrenic acid;Affect;Age related macular degeneration;age-related disease;Aging;aging related;Arachidonic Acids;Beta-glucuronidase;Biochemical Process;Biological;Biological Markers;biomarker identification;Brain;Cardiovascular Diseases;cell injury;chemical stability;Classification;Clinical Research;Clinical Trials;colorectal cancer prevention;Complex;Detection;Diabetes Mellitus;Diet;dietary;Disease;Docosahexaenoic Acids;Dose;Eicosapentaenoic Acid;Ensure;Evaluation;experimental study;extend lifespan;Eye;F2-Isoprostanes;Failure;Fatty Acid Desaturases;Fatty Acids;Fish Oils;frailty;Free Radicals;Functional disorder;Future;Glucuronides;Glucuronosyltransferase;Health;Homeostasis;Human;human disease;human model;in vivo;Incubated;Intervention;Investigation;Isomerism;Knowledge;Laboratories;Light;Link;Lipid Peroxidation;Lipids;Literature;Liver Microsomes;Malignant Neoplasms;marine;Mass Spectrum Analysis;Measures;Metabolic;Metabolic Pathway;Metabolism;metabolome;Methods;Nerve Degeneration;novel;Olive oil preparation;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Outcome Measure;oxidation;Oxidation-Reduction;Oxidative Stress;oxidized lipid;Pathogenesis;peroxidation;Phase;Physiology;Plasma;Polyunsaturated Fatty Acids;programs;Public Health;public health relevance;randomized, clinical trials;recruit;Reporting;Role;Route;sample collection;Sampling;SARS coronavirus;Testing;Time;Tissues;translational potential;Uridine;urinary;Urine;Validation

PROJECT_TITLE: Comprehensive Determination of Isoprostanoid Metabolism

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Contraception/Reproduction;Genetics;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: NARRATIVE Preeclampsia (PE) remains a poorly understood, multiorgan vascular disease that is responsible for the death of up to 50,000 women and 1 million infants per year. Our goal is to determine whether a novel NF-κB variant increases PE risk by enhancing inflammatory cytokine responses of the vascular endothelium that, in turn, impair uteroplacental blood flow. Our study will accelerate the understanding of maternal-fetal genetics and its role in the development of PE and may also identify candidate pathways to direct future functional experiments and potential avenues for therapeutic intervention.

PI_NAMEs: JULIAN, COLLEEN GLYDE (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Acceleration;Admixture;Altitude;Altitude Sickness;Andean;attributable mortality;Beds;Biopsy;Blood flow;Blood Vessels;Bolivia;Bolivian;candidate identification;Cessation of life;Characteristics;Child;Chronic;Circulation;cohort;CRISPR/Cas technology;cytokine;Data;Development;Disease;DNA;Doppler Ultrasound;Economic Burden;Etiology;experience;experimental study;Family;fetal;Fetal Growth;Fetal Reduction;Functional disorder;Future;gene editing technology;gene network;Genes;Genetic;Genetic Transcription;genetic variant;Genotype;Goals;Human;Hypertension;Hypoxia;Impairment;improved;Incidence;Individual;Infant;Inflammatory;Inflammatory Response;Inflammatory Response Pathway;insight;Invaded;Knowledge;Laboratories;Latin America;life span;Link;Machine Learning;Maternal Mortality;Maternal-Fetal Exchange;Measures;Methods;Molecular;Morbidity - disease rate;mortality;Mothers;multi-ethnic;multiplex assay;National Institute of Child Health and Human Development;NF-kappa B;Nitric Oxide;normotensive;NOS3 gene;novel;novel strategies;offspring;Organ;Pathway interactions;Perfusion;perinatal period;Phenotype;Physiological;Placenta;Placenta Diseases;Placentation;Polycythemia;Population;Pre-Eclampsia;Predisposition;Pregnancy;pregnancy disorder;Prevention strategy;Production;programs;Public Health;reduced uteroplacental blood flow;Regulation;reproductive outcome;Research;response;Risk;Risk Factors;risk variant;Role;Sampling;Sea;Spiral Artery of the Endometrium;study population;System;Techniques;Therapeutic Intervention;Time;TNF gene;transcription factor;transcriptome sequencing;trophoblast;tumor-immune system interactions;Umbilicus;United States National Institutes of Health;Uterus;Variant;variant of interest;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;Venous;Villous;Woman

PROJECT_TITLE: Novel NF-kB variant in preeclampsia

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Anthrax;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE This proposal is relevant to public health because it elucidates a fundamental and general property of bacterial spore formation that plays a critical role in causing human disease. These studies are relevant to NIH’s mission to acquire knowledge that is important in the development of new strategies to treat and prevent infections disease. These studies are also important for NIH's national defense mission because they define a critical feature of Bacillus anthracis spores, the causative agent of anthrax and a serious threat as an agent of bioterrorism.

PI_NAMEs: TURNBOUGH, CHARLES LEE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Aerobic;Amino Acids;Animals;Anthrax disease;Bacillus;Bacillus anthracis;Bacillus anthracis spore;Bacteria;Bacterial Spores;Bioterrorism;bioweapon;Cells;Clostridium;Collagen;Complex;covalent bond;crosslink;design;Detection;Detergents;Deuterium;Development;Disease;Disease Progression;Electrons;Elements;Energy-Generating Resources;Filament;Genetic;genetic analysis;Glycoproteins;Goals;hair-like nap;Human;human disease;human pathogen;Hydrogen;In Vitro;Individual;Infection prevention;Knowledge acquisition;Length;Mass Spectrum Analysis;Methods;Mission;Modeling;molecular marker;molecular mass;molecular modeling;monomer;Mothers;Mutagenesis;mutant;Mutation;Napping;Nutrient;nutrient deprivation;Organism;Outcome;Outcome Study;pathogen;pathogenic bacteria;Peptides;Play;Process;Property;protein complex;protein function;Proteins;Proteolytic Processing;Public Health;Reducing Agents;Reproduction spores;Research;Resistance;Role;scaffold;Soil;Starvation;Stratum Basale;Structure;Surface;Techniques;Testing;tool;United States National Institutes of Health;Variant;X-Ray Crystallography

PROJECT_TITLE: Describing the stable, non-covalent BclA-BxpB attachment in B. anthracis spores

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Tobacco

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Emerging evidence indicates that vulnerable groups, such as Native Hawaiian, Pacific Islander, and Filipino (NHPIF) young adults, use e-cigarettes and cannabis at higher rates than other racial/ethnic groups, but past research has not examined co-use. The current phased study will utilize epidemiological data from two sources to guide the development of a Just-in-Time Adaptive Intervention (JITAI) for NHPIF young adults ages 18-30 who co-use e-cigarettes and cannabis. Following pilot work, a randomized controlled trial of the JITAI will examine the impact of the new intervention on frequency of e-cigarette, cannabis, and co-use and related problems.

PI_NAMEs: PHILLIPS, KRISTINA T. (contact);POKHREL, PALLAV

PROGRAM_OFFICER_NAME: ROMBERG, ALEXA RUTH

PROJECT_TERMS: adaptive intervention;Advertising;Age;American;Asian Americans;Behavioral Risk Factor Surveillance System;Calibration;Cannabis;Cardiovascular Diseases;Cognitive;cohort;Communities;Complement;Data;Data Set;Dependence;Development;Ecological momentary assessment;Electronic cigarette;electronic cigarette use;epidemiologic data;Epidemiology;Equilibrium;Ethnic Origin;Ethnic Population;Family;Filipino;Frequencies;Funding;Geography;Goals;group intervention;Hawaii;Health;Health behavior;health disparity;implementation intervention;indexing;Intake;Intervention;intervention refinement;Interview;Island;Link;low socioeconomic status;Maintenance;Malignant Neoplasms;marijuana use;Marketing;Measures;Mental Health;mortality;Native Hawaiian or Other Pacific Islander;nicotine use;novel;Outcome;Pattern;peer influence;Persons;Phase;physical conditioning;post-COVID-19;Prevalence;racial population;Randomized, Controlled Trials;recruit;Relative Risks;Reporting;Research;Research Personnel;Respondent;response;Risk;Risk Factors;Sales;Sample Size;Sampling;secondary analysis;smartphone application;social culture;social health determinants;social influence;social media;Social Network;social vulnerability;Source;Subgroup;substance use;Surveys;Time;Tobacco;tobacco products;Translating;United States National Institutes of Health;Vulnerable Populations;Work;young adult

PROJECT_TITLE: Leveraging epidemiological data to inform the development of a just-in-time adaptive intervention for diverse young adults co-using e-cigarettes and cannabis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 MXS-E (O1)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Neurosciences;Precision Medicine;Prevention;Stroke

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Narrative  This proposal will perform RNAseq on blood of a derivation cohort of subarachnoid hemorrhage (SAH) patients to determine those genes that best predict Delayed Cerebral Ischemia (DCI) between 4 and 14 days and that predict median Rankin Scores (mRS) outcomes at 90 days using cross-correlation. These genes are then measured in an independent validation cohort of SAH patients to predict who develops DCI by 14d, and to predict their mRS at 90 days after SAH. The studies will direct early treatment for DCI, identify treatment targets for DCI, and help stratify patients for future DCI treatment trials.

PI_NAMEs: ANDER, BRADLEY PEARCE;SHARP, FRANK R (contact);STAMOVA, BORYANA

PROGRAM_OFFICER_NAME: TAYLOR-BURDS, CAROL C

PROJECT_TERMS: 3-Dimensional;Affect;Age;Aneurysm;Aneurysmal Subarachnoid Hemorrhages;Angiography;Arteries;biomarker signature;Blood;Blood - brain barrier anatomy;care costs;Catheters;Cerebral hemisphere hemorrhage;Cerebral Infarction;Cerebral Ischemia;cerebral microvasculature;Cerebrovascular Spasm;Cerebrum;Clinical;Clinical Trials;Clip;Coagulation Process;Cognitive;cohort;Complication;cost;Derivation procedure;Diagnosis;Early treatment;Endothelin Receptor Antagonist;Enrollment;FDA approved;Future;Gene Expression;Genes;Hemorrhage;Human;Image;improved;improved outcome;Inflammation;Inflammatory;Ischemia;Ischemic Stroke;Machine Learning;Measures;Medical;Meta-Analysis;Modeling;Morbidity - disease rate;mortality;Myocardial dysfunction;Neurologic;Nimodipine;Outcome;outcome prediction;Pathway interactions;patient stratification;Patients;Peripheral;peripheral blood;Pharmaceutical Preparations;Phase;Placebos;prevent;Prevention;Pulmonary Edema;Quantitative Reverse Transcriptase PCR;randomized, clinical trials;repaired;Resource Allocation;Sensitivity and Specificity;Societies;spreading depression;Stroke;stroke patient;Subarachnoid Hemorrhage;support vector machine;Survivors;Systemic Inflammatory Response Syndrome;Thrombosis;Training;transcriptome;transcriptome sequencing;treatment trial;Validation;vascular inflammation;vascular risk factor;Vasospasm;Whole Blood;whole genome;Work

PROJECT_TITLE: Biomarker Signatures for Delayed Cerebral Ischemia and Outcome Following Subarachnoid Hemorrhage

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


NIH_SPENDING_CATS: Genetics;Lung

PHR: PROJECT NARRATIVE: The airways are lined by dense fields of motile cilia that generate a directional fluid flow that is critical for clearing mucus, pathogens, and debris from the airways. Disruptions in the ciliary apparatus, whether due to a genetic disorder or infective and acquired causes, are directly linked to infection and disease progression. The goal of this study is to better understand how the spatial organization of the airway epithelium regulates airway clearance in diseases characterized by genetic changes in motile cilia. 1

PI_NAMEs: KANSO, EVA ;RYAN, AMY LEANNE (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Address;Affect;airway epithelium;Asthma;Biomechanics;cell type;Cells;Characteristics;Chronic Bronchitis;Chronic lung disease;Cilia;ciliopathy;cilium motility;Clinical;Complex;Cystic Fibrosis;Defect;Defense Mechanisms;design;Disease;Disease Progression;Epithelium;fluid flow;Functional disorder;gene-editing approach;Genetic Diseases;Genotype;Goals;Human;Impairment;in silico;In Vitro;in vitro Model;in vivo;Infection;Inherited;Knowledge;Link;Lung;Lung Diseases;Maps;Measures;Mechanics;Mediating;Modeling;Mucociliary Clearance;Mucous body substance;Mutation;novel therapeutic intervention;pathogen;Patients;Phenotype;Physics;pre-clinical;precision medicine;Primary Ciliary Dyskinesias;programs;Property;Research;respiratory;Respiratory Disease;Respiratory System;Secretory Cell;small molecule;Structure;Structure of parenchyma of lung;Structure-Activity Relationship;therapeutic genome editing;Tissues;tool;Tracheobronchial;Treatment Protocols;Variant

PROJECT_TITLE: Quantitative analysis of mucociliary clearance in airway ciliopathies

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: Health Relevance Cryptosporidial infection remains significant in AIDS patients and young children. The proposed research will study the molecular mechanisms by which Cryptosporidium interacts with host epithelial cells and evades host defense, and could potentially be exploited for the development of new therapeutic strategies targeting these mechanisms.

PI_NAMEs: CHEN, XIAN-MING  (contact)

PROGRAM_OFFICER_NAME: PESCE, JOHN T

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;AIDS-Related Opportunistic Infections;antimicrobial;Attenuated;Biochemical;Biology;Cells;Child;cost;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;Data;Developing Countries;Development;Diarrhea;Disease;effective therapy;Epithelial Cells;Epithelium;experience;Family;Family member;Functional disorder;Future;gastrointestinal epithelium;Genes;Genetic Transcription;Grant;Health;Highly Active Antiretroviral Therapy;HIV diagnosis;Host Defense;Human;Immunity;In Vitro;in vivo;Infection;innovation;Interferon Activation;Interferon alpha;Interferon Type II;Interferon-beta;Interferons;intestinal epithelium;Intestines;Knock-out;Mediating;minimally invasive;Modeling;Molecular;monolayer;Morbidity - disease rate;Morphology;mortality;Mucous Membrane;Mus;novel;novel therapeutic intervention;opportunistic pathogen;Outcome;Parasites;Partitiviridae;pathogen;Pathogenesis;Pathogenicity;Patients;Persons;Predisposition;prevent;Proteins;receptor;Research;Resistance;response;RNA;RNA delivery;Role;sensor;Signal Pathway;Signal Transduction;Societies;STAT protein;STAT1 protein;Surface;Testing;three-dimensional modeling;Translations;Virus

PROJECT_TITLE: Molecular basis of intestinal cryptosporidiosis


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_NAME: MICHAEL E DEBAKEY VA MEDICAL CENTER

PHR: Veterans with post-traumatic stress disorder (PTSD) frequently have insomnia (trouble falling or staying asleep). Untreated insomnia carries grave health consequences. Early evidence suggests that pimavanserin (Nuplazid), a medication approved by the Food and Drug Administration for the treatment of psychosis (hallucinations and delusions) in Parkinson’s Disease, may treat insomnia. In this preliminary study, Veterans with insomnia and PTSD will receive either pimavanserin 34mg or placebo at bedtime for 8 weeks, and sleep quality will be compared pre- and post-treatment. Veterans will also complete sleep studies and wear actigraphy watches so we may better appreciate how pimavanserin impacts sleep. Overall, this study will help us understand pimavanserin’s potential benefit for treating PTSD-related insomnia and prepare for a larger, future trial.

PI_NAMEs: JONES, MELISSA BETH (contact)

PROJECT_TERMS: actigraphy;addiction liability;Address;Adult;Adverse event;Aftercare;Agonist;Applications Grants;atypical antipsychotic;Award;behavioral neurology;Benzodiazepines;Biometry;Book Chapters;career;career development;Cementation;Chicago;Chronic Insomnia;Chronic Post Traumatic Stress Disorder;Clinical;clinical center;Clinical Trials;Clinical Trials Design;Cognitive Therapy;college;Country;Delusions;design;Double-Blind Method;Dropout;Drowsiness;DSM-V;Education;effective intervention;Effectiveness;efficacy clinical trial;efficacy evaluation;Enrollment;Environment;evidence base;Faculty;falls;Fellowship;Female;Funding;Future;GABA Agonists;Goals;Hallucinations;hangover;Health;Health Services Research;healthy volunteer;HTR2A gene;Illinois;improved;improvement on sleep;indexing;innovation;Instruction;Intervention;male;Manuscripts;Measures;Medical center;medical schools;Medicine;meetings;memory consolidation;memory process;Mental disorders;Mental Health Services;Mentors;Mentorship;Neurodegenerative Disorders;neuropsychiatry;novel;Outcome Measure;Parkinson Disease;Patients;Peer Review;Pharmaceutical Preparations;Pharmacological Treatment;Pharmacology;Placebo Control;placebo group;Placebos;Polysomnography;Post-Traumatic Stress Disorders;post-traumatic symptoms;primary outcome;professor;Protocols documentation;Psychiatrist;Psychiatry;Psychopathology;Psychoses;Psychotherapy;Publishing;Randomized;randomized, clinical trials;Refractory;Reporting;Research;Residencies;Resistance;Risk;Safety;Sampling;Scientist;screening;Severities;side effect;Sleep;Sleep Architecture;Sleep disturbances;sleep onset;sleep quality;Sleeplessness;Slow-Wave Sleep;Stage I Sleep;statistics;Stress;suicidal risk;supplemental instruction;Symptoms;Time;Training;Trazodone;United States Food and Drug Administration;Universities;Veterans

PROJECT_TITLE: Pimavanserin for Insomnia in Veterans with Post-traumatic Stress Disorder


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_DEPT: ORTHOPEDICS

PHR: PROJECT NARRATIVE What determines the length of the jaw skeleton? Answering this question is important for preventing and treating birth defects, as well as for devising new therapies to repair or regenerate bones affected by injury or disease. The overall goal of this project is to identify molecular and cellular mechanisms that control jaw length.

PI_NAMEs: SCHNEIDER, RICHARD A (contact)

PROGRAM_OFFICER_NAME: SAIFUDEEN, ZUBAIDA

PROJECT_TERMS: acute myeloid leukemia 1 protein;Address;Affect;Alternative Splicing;Animal Model;Binding Sites;Biological Models;bone;Bone Growth;Bone Regeneration;Bone Resorption;Cell Proliferation;Cell Therapy;Cellular Assay;Chick;Chimera organism;Clinical;clinically relevant;collagenase;collagenase 3;combinatorial;comparative;Complement;Complex;Congenital Abnormality;Coturnix japonica;craniofacial;Data;Defect;Deposition;Development;differential expression;Disease;Ducks;Economic Burden;Elements;Embryo;Evolution;experimental study;gain of function;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;Goals;Human;in vivo;Inhibition of Matrix Metalloproteinases Pathway;Injury;innovation;Jaw;Knowledge;Length;Ligands;Link;Live Birth;loss of function;Malocclusion;Mandible;Maxilla;Mediating;member;Mesenchymal;Mesenchyme;Micrognathism;migration;Modification;Molecular;Mutation;Neural Crest;novel;novel therapeutics;Operative Surgical Procedures;Orthodontics;Osteogenesis;osteogenic;overexpression;Pain;Pathway interactions;Patients;Pattern;Phenotype;precision medicine;precursor cell;Prevalence;prevent;progenitor;promoter;Protein Isoforms;Publishing;Quail;receptor;Receptors, Adrenergic, beta-1;Regulation;Regulatory Element;repaired;Research;response;Signal Pathway;Signal Transduction;Single Nucleotide Polymorphism;skeletal;Skeleton;social;Specific qualifier value;Structure;System;targeted treatment;Testing;transcription factor;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Transforming Growth Factor beta Receptors;Transplantation;Variant;Work

PROJECT_TITLE: Mesenchymal Regulation of Osteogenesis

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

PHR: This VA Merit Review Application is highly relevant to the health of Veterans, as it seeks to develop novel biomarkers to improve risk stratification of Veterans with significant liver disease who have achieved HCV cure. The Department of Veterans Affairs is the single largest hepatitis C virus infection health care provider in the United States. Since the introduction of direct acting antivirals for the treatment of HCV infection in 2014, VA has cured over 100,000 Veterans. Due to the high rate of comorbidities in the veteran population, including HIV co- infection, alcohol use, and obesity and metabolic syndrome, rates of severe liver fibrosis prior to DAA therapy are high and likely to persist despite cure. To date there are no reliable laboratory tests or biomarkers to differentiate patients with the greatest risk of post-SVR decompensation events, HCC, and liver-related death. This is a critical unmet clinical need that is highly relevant to clinicians who care for Veterans cured of their HCV infection, but with significant residual liver disease and/or ongoing liver injury.

PI_NAMEs: MOYLAN, CYNTHIA A;NAGGIE, SUSANNA  (contact)

PROJECT_TERMS: acylcarnitine;Alcohol consumption;Amino Acids;Anti-viral Agents;Anti-viral Therapy;Ascites;Bile Acids;Biological;Biological Markers;Biology;biomarker validation;biosignature;Blood;Caring;case control;Ceramides;Cessation of life;Cirrhosis;Clinical;clinical predictors;co-infection;cohort;comorbidity;design;Development;Disease;Enrollment;Ensure;Esophagus;Etiology;Event;fatty acid oxidation;Fibrosis;follow-up;Future;Goals;HCV Cirrhosis;Health;Health Personnel;Hemorrhage;Hepatic;Hepatic Encephalopathy;Hepatitis C;Hepatitis C co-infection;Hepatitis C Therapy;Hepatitis C virus;high dimensionality;high risk;HIV;HIV/HCV;improved;Knowledge;Laboratories;Lecithin;lipid metabolism;Lipids;Liver;liver cancer model;Liver diseases;Liver Fibrosis;liver injury;Mediating;Membrane Lipids;Metabolic;metabolic profile;Metabolic syndrome;metabolomics;military veteran;Modeling;mortality;multiple omics;Nested Case-Control Study;new therapeutic target;non-alcoholic fatty liver disease;novel;novel marker;novel therapeutics;Obesity;Observational Study;Pathogenesis;Pathway interactions;Patients;Peripheral;peripheral blood;Peritonitis;Persons;Pilot Projects;Plasma;predict clinical outcome;predictive modeling;Primary carcinoma of the liver cells;prognostic;prospective;Proteins;Proteomics;Residual state;response;Risk;risk prediction;risk stratification;Site;Sphingomyelins;Subgroup;Testing;therapeutic target;Tissues;Transcript;transcriptomics;Translational Research;United States;United States Department of Veterans Affairs;Validation;Veterans;Viral

PROJECT_TITLE: Applying an 'omics' approach to predict hepatic decompensation events and hepatocellular carcinoma in veterans after HCV cure with direct acting antiviral therapy


ORG_CITY: SALT LAKE CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The main focus of the University of Utah (UU) Medical Student Research Program is to introduce medical students to basic and clinical research. Medical students from the UU and University of Puerto Rico work with established mentors on heart, lung, and/or blood research generating results that are presented at local and national meetings and published in peer-reviewed journals. These experiences prepare medical students for futures in academic medicine.

PI_NAMEs: RONDINA, MATTHEW THOMAS;TRISTANI-FIROUZI, MARTIN  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: aluminum sulfate;Basic Science;Blood;career;Clinical Research;Doctor of Philosophy;Enrollment;Ethics;Evaluation;experience;Exposure to;Extramural Activities;Faculty;faculty mentor;falls;Financial Support;Fostering;Funding;Goals;Grant;Health Professional;Health Sciences;Heart;Institution;interest;Laboratories;Lung;Medical Records;medical schools;Medical Students;Medicine;meetings;Mentors;Participant;Physicians;Positioning Attribute;posters;programs;Publishing;Puerto Rico;Recording of previous events;Records;Research;Research Personnel;Review Committee;Schools;Scientist;Structure;Students;summer program;summer research;symposium;Training;Training Programs;Translational Research;Universities;university student;Utah;Work;Writing

PROJECT_TITLE: Short-term Training: Students in Health Professional Schools


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Brain function depends on the integration of multiple neural structures and processes that currently cannot be studied at a whole-brain level in living organisms. To address this problem, we introduce a novel technology called hemogenetic imaging, which will enable the biology of genetically-targeted cells to be comprehensively studied by functional magnetic resonance imaging (fMRI) or related techniques. Here we propose to apply hemo- genetic fMRI to study brain-wide aspects of sensory processing, resting state dynamics, and neurovascular cou- pling. We will also improve the technology itself, setting the stage for many future applications.

PI_NAMEs: JASANOFF, ALAN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Address;Animals;Autopsy;Behavior;Biological Models;Biology;Blood flow;Brain;Brain imaging;Brain region;Calcium;cell type;Cells;Data;Detection;Disadvantaged;Elements;experience;experimental study;Family;Feedback;Fluorescence;Foundations;Functional Imaging;Functional Magnetic Resonance Imaging;Future;Gene Expression;Genetic;hemodynamics;Human;Image;imaging modality;improved;Injections;insight;Investigation;Label;Lead;Maps;Measurement;Measures;Methods;Modeling;Molecular;Molecular Probes;Monitor;neural;neural circuit;neuroimaging;Neurons;Neurophysiology - biologic function;neuroregulation;Neurosciences;neurovascular coupling;new technology;non-invasive imaging;novel therapeutics;Organ;Organism;Output;Pathway interactions;Performance;Peripheral;personalized approach;pharmacologic;Population;premonitory sensory phenomena;Process;promoter;Property;Rattus;Reporter;Reporter Genes;Research;Research Personnel;response;Rest;Rewards;Rodent;Role;Sensory;sensory input;sensory stimulus;Signal Transduction;somatosensory;Somatosensory Cortex;Source;spatiotemporal;Specificity;stimulus processing;Structure;System;Techniques;Technology;Thalamic Nuclei;Time;tool;Tracer;ultra high resolution;ultrasound;Viral;Viral Vector

PROJECT_TITLE: Analysis of Integrated Brain Functions Using Hemogenetic Imaging

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Cancer;Contraception/Reproduction;Infertility;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project narrative: The goal of this project is to understand how MIS protects fertility in mice receiving chemotherapy to inform the development of new therapeutic options for female cancer survivors. These therapies would address a significant unmet medical need, which is rapidly growing as cancer outcomes improve. At the end of these studies we will understand the cell types and cell responses regulated by MIS in the ovary and uterus, and have provided a path to scalability and sustainability for the clinical development of a novel class of fertoprotective drug candidates.

PI_NAMEs: PEPIN, DAVID  (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Acceleration;Address;Agonist;analog;Apoptosis;bevacizumab;Blood Vessels;burnout;Cancer Patient;Cancer Survivor;cancer therapy;Carboplatin;cell type;Cells;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;Clinical;clinical care;clinical development;Contraceptive Agents;Cyclophosphamide;design;Development;Doxorubicin;drug candidate;drug repurposing;embryo cryopreservation;Endocrine;Endometrial;Feedback;Female;female fertility;female reproductive tract;Fertility;fertility preservation;Fibrosis;gemcitabine;girls;GNRH1 gene;Goals;granulosa cell;Growing Follicle;Homeostasis;Hormonal;Hormones;Human;improved outcome;In Situ;Infertility;innovation;insight;Labor Dystocia;Life;Low Birth Weight Infant;Malignant Neoplasms;Medical;Methods;mimetics;mouse model;mullerian-inhibiting hormone;Mullerian-inhibiting substance receptor;Mus;Muscle;myometrium;novel;novel therapeutics;oocyte cryopreservation;Organ;Ovarian;ovarian damage;ovarian reserve;Ovary;Paclitaxel;paracrine;Pathway interactions;Pelvis;Pharmaceutical Preparations;Premature Birth;Premature Menopause;prevent;primary ovarian insufficiency;Primordial Follicle;progenitor;Property;protective effect;protective pathway;Radiation;Radiation Toxicity;receptor;Recombinants;recruit;repaired;Reproductive Biology;Resolution;response;Rest;Risk;Risk Reduction;single-cell RNA sequencing;small molecule;Spontaneous abortion;standard of care;Survivors;Testing;Therapeutic;therapeutic target;Thick;Time;tissue repair;Toxic effect;Toxicity due to chemotherapy;transcriptomics;Transgenic Mice;Translating;Treatment outcome;Uterus;women patients;women's reproductive health;young woman

PROJECT_TITLE: Methods of fertility protection by Mullerian inhibiting substance in the female reproductive tract during chemotherapy


NIH_SPENDING_CATS: Biotechnology;Chronic Pain;Gene Therapy;Genetics;Human Genome;Neurosciences;Pain Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Current treatment options for refractory pain are associated with dangerous side effects that stem from their off- target activity. The proposed study leverages recent advances in single-cell genomics to build viral tools that selectively express in the peripheral sensory neurons that detect and transmit pain signals. These new viral tools will facilitate pain research in animal models in multiple species and have the potential to provide analgesia to patients with unprecedented precision.

PI_NAMEs: RENTHAL, WILLIAM RUSSELL (contact)

PROJECT_TERMS: Absence of pain sensation;addiction;Adult;Affect;Afferent Neurons;Animal Model;Atlases;Bar Codes;Bioinformatics;Biological Assay;Cell Nucleus;cell type;Cells;Central Nervous System;Characteristics;Chromatin;Chromatin Structure;chronic pain;clinical pain;Cognition;Communities;Dangerousness;Data;design;disability;Distal;Elements;Engineering;Enhancers;Enterobacteria phage P1 Cre recombinase;epigenomics;Esthesia;experience;gene conservation;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene therapy;Gene Transfer;Generations;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Heterogeneity;Histone Acetylation;Human;improved;In Situ Hybridization;in vivo;infancy;insight;Intractable Pain;Ion Channel;Libraries;Maps;Mediating;Medicine;Molecular;Mus;Neurons;Neuropathy;next generation;Nociceptors;Opioid;optogenetics;Outpatients;Pain;Pain Disorder;Pain management;pain model;Pain Research;pain signal;painful neuropathy;Patients;Peripheral;Pharmaceutical Preparations;Positioning Attribute;Procedures;promoter;Property;Refractory;Regulatory Element;Research;Resolution;Safety;screening;selective expression;Sensory Ganglia;side effect;single cell genomics;single nucleus RNA-sequencing;Specificity;Spinal Ganglia;stem;Therapeutic;tool;Translating;translational applications;transmission process;Transposase;United States;United States Food and Drug Administration;Ventilatory Depression;Viral;Viral Vector;Virus;Wild Type Mouse

PROJECT_TITLE: Next Generation Gene Therapy for Refractory Pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Sexual and gender minority (SGM) youth and emerging adults are at high risk of suicide attempts and death by suicide, and no known suicide prevention programs exist for this vulnerable population. The proposed study will adapt and test an intervention that integrates patient navigation with safety planning to prevent suicide. This intervention program for SGM youth and emerging adults is designed to target mechanisms that theoretically underlie suicide.

PI_NAMEs: BLASHILL, AARON J (contact);WELLS, KRISTEN JENNIFER

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: acceptability and feasibility;Adolescent;Age;Birth;Cause of Death;cisgender;Clinical;Communities;comparison intervention;completed suicide;Coping Skills;cost;Data;design;Disparity;efficacy trial;emerging adult;experience;Family;feasibility testing;Friends;Future;Gender;gender minority;gender minority youth;General Population;Grant;health disparity;Health Resources;Heterosexuals;high risk;Individual;innovation;Intervention;intervention participants;intervention program;Lesbian Gay Bisexual;Literature;longitudinal analysis;Longitudinal Studies;Mental Health;Meta-Analysis;Methods;Motivation;nonbinary;Participant;patient navigation;patient navigator;Persons;Phase;pilot test;pilot trial;Population;population based;Preparation;Prevalence;Prevention program;preventive intervention;Problem Solving;programs;psychologic;Public Health;Randomized;Randomized, Controlled Trials;Recording of previous events;reducing suicide;Reporting;Research;Resources;Safety;Sampling;Services;sex;Sexual and Gender Minorities;sexual minority;sexual minority youth;Social support;suicidal;suicidal morbidity;Suicide;Suicide attempt;Suicide prevention;Support Groups;Testing;therapy design;transgender;trend;Vulnerable Populations;Youth

PROJECT_TITLE: Suicide Prevention for Sexual and Gender Minority Youth


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Digestive Diseases;Heart Disease;Microbiome;Nutrition;Obesity;Prevention

ORG_NAME: BROAD INSTITUTE, INC.

PHR: Understanding how the metabolic activity of the gut microbiome contributes to host cardiovascular disease risk through modulation of cholesterol levels has important translational implications. Working with the Framingham Heart Study (FHS) we profiled participant microbiomes, identifying a novel group of cholesterol dehydrogenases that metabolize cholesterol and result in lower serum cholesterol in subjects whose microbiomes encode these enzymes. In this proposal, we will utilize multi-’omics data generation (metagenomics, metabolomics, transcriptomics), cell-based assays, and a state-of-the art gnotobiotic mouse pipeline to functionally identify the gut microbes and enzymes that metabolize cholesterol, corticosteroids, or phytosterols and determine the mechanisms through which cholesterol metabolism impacts cardiovascular health.

PI_NAMEs: XAVIER, RAMNIK J (contact)

PROGRAM_OFFICER_NAME: HONG, YULING

PROJECT_TERMS: absorption;Adrenal Cortex Hormones;Affect;Atherosclerosis;Bacteria;Biochemistry;Bioinformatics;Biological Assay;Biological Availability;Biology;Cardiometabolic Disease;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Cells;Cholesterol;cholesterol dehydrogenase;Cholesterol Homeostasis;cholesterol transporters;Circulation;Clinical;Clinical Data;cohort;Cohort Studies;commensal microbes;Coupled;Coupling;cytokine;Data;Data Set;Disease;disorder risk;Engineering;enzyme activity;Enzymes;Epithelial Cells;Feces;Framingham Heart Study;Generations;Genes;Genetic Transcription;Gnotobiotic;Goals;gut bacteria;gut microbes;gut microbiome;gut microbiota;Health;host-microbe interactions;Human;human disease;Immune;In Vitro;Inflammation;intestinal epithelium;Intestines;Investigation;Libraries;Link;Lipids;Liver;Measures;Medical;member;Metabolic;Metabolic Diseases;Metabolic syndrome;Metabolism;metabolomics;metagenomic sequencing;Metagenomics;Microbe;microbial;microbial community;Microbiology;microbiome;Multiomic Data;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Paper;Participant;Pathway interactions;Persons;Phenotype;Phytosterols;Plants;Process;Production;Proteins;Proteomics;Publishing;reconstitution;Risk Factors;Sampling;Serum;Steroids;Sterols;Structure;Substrate Specificity;System;transcriptomics;Work

PROJECT_TITLE: Cardiovascular disease, metabolic syndrome, microbes and metabolites in FHS

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Digestive Diseases;Emerging Infectious Diseases;HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PI_NAMEs: HERNAN, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Africa;analytical method;Anti-Retroviral Agents;Clinical;Clinical Management;co-infection;cohort;Collaborations;Communities;Complex;Computer software;cost;COVID-19;COVID-19 incidence;COVID-19 severity;Data;Development;Disease;Documentation;effectiveness evaluation;Epidemiology;Europe;Event;Extrahepatic;follow-up;Funding;Goals;Hepatic;Hepatitis C virus;high risk;HIV;HIV Seropositivity;HIV/HCV;improved;Incubators;Individual;Infection;innovation;Instruction;interest;International;Journals;Liver diseases;Long-Term Effects;Longitudinal Studies;Medical;Methodology;Methods;Monitor;Morbidity - disease rate;mortality;North America;Outcome;Paper;Patients;Persons;Pharmaceutical Preparations;Principal Investigator;programs;Progress Reports;prospective;randomized, clinical trials;Research;Research Personnel;Role;Safety;Specific qualifier value;tool;treatment strategy;user friendly software;web site;Work

PROJECT_TITLE: Dynamic Strategies for the clinical management of HIV disease

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS