NIH_SPENDING_CATS: Aging;Genetics;Human Genome

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative This project aims understand the role of chromatin-tethering proteins in organizing the genome at the nuclear lamina. Emerging data suggest that chromatin organization at the nuclear lamina is a critical mechanism of epigenetic regulation of the genome, instabilities of which lead to premature aging, some forms of heart failure and tumorigenesis. Understanding how chromatin is tethered to the nuclear lamina will advance our understanding of the molecular mechanisms underlying the cause of these diseases, while also adding to our fundamental knowledge of spatial genome organization in the nucleus.

PI_NAMEs: POLESHKO, ANDREY  (contact)

PROGRAM_OFFICER_NAME: GUO, MAX

PROJECT_TERMS: Adopted;Affect;aging mechanism;Binding;Biological Assay;Cell Nucleus;Cells;Chromatin;Cleavage Under Targets and Release Using Nuclease;Data;Defect;Development;Disease;DNA Sequence Alteration;domain mapping;Epigenetic Process;epigenetic regulation;experimental study;Farnesyl Transferase Inhibitor;Gene Silencing;Genetic Transcription;Genome;genome-wide;Genomic approach;Goals;Heart failure;Heterochromatin;heterochromatin-specific nonhistone chromosomal protein HP-1;Histone H3;histone modification;imaging approach;insight;Interruption;Investigation;knock-down;Knowledge;Lamin Type A;Link;Maintenance;Maps;Methylation;Modification;Molecular;Morphology;mutant;Mutation;Nuclear;Nuclear Lamin;Nuclear Lamina;overexpression;Peripheral;Play;population based;Positioning Attribute;Premature aging syndrome;Process;Progeria;proline-rich proteins;Protein Isoforms;Proteins;Regulation;Role;Site;Structure;Surface;Syndrome;Testing;transcriptome sequencing;tumorigenesis;Work

PROJECT_TITLE: Understanding the role of tether proteins to maintain chromatin-nuclear lamina contacts in premature aging.

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Our long-term goal is to accurately identify who is at risk of driving decline, to establish whether daily driving behavior can be used as a neurobehavioral biomarker of cognitive impairment and dementia, to forecast when driving decline will occur, to intervene before the time of decline, and to prevent a significant number of crashes, injuries, and death. By 2050, 1 in 4 drivers will be age 65 or older, and currently, motor vehicle crashes are a leading cause of injury and death among older adults, with symptomatic Alzheimer disease (AD), while sensory and motor functioning independently increasing the risk of a crash. Driving data continuously collected from the natural environment can establish a unique driver profile, determine whether that profile can predict preclinical AD via molecular biomarkers and the onset of dementia, and ascertain whether various cognitive and behavioral measures improve its predictive ability.

PI_NAMEs: BABULAL, GANESH M (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Accelerometer;Activities of Daily Living;age group;aging brain;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Area;Area Under Curve;Automobile Driving;Behavior;behavior measurement;Biological;Biological Markers;Biostatistical Methods;Blood;blood-based biomarker;Cerebrospinal Fluid;Cessation of life;Clinical;Clinical Trials;Cognition;Cognitive;cognitive ability;cohort;comorbidity;Complex;cost;Data;Data Collection;data standards;Dementia;Diagnostic;Digital biomarker;Disease Progression;driving behavior;driving performance;Enrollment;Environment;Evaluation;executive function;fitness;Frequencies;Functional impairment;Future;Global Positioning System;Goals;Health;Home;human old age (65+);Image;imaging biomarker;Impaired cognition;improved;in vivo;Individual;Infrastructure;Injury;Institution;instrumental activity of daily living;Intervention;Knowledge;Length;Licensing;Licensure;Liquid substance;Maps;Measures;Methodology;Methods;mobile application;molecular marker;Monitor;Motor;multidisciplinary;neurobehavioral;neuroimaging marker;neuropathology;Neuropsychological Tests;Neuropsychology;novel;older adult;older driver;Participant;Persons;Population;pre-clinical;prevent;Proxy;Public Health;Research;response;Risk;Sea;Sensory;skills;Speed;Spinal Puncture;Symptoms;System;tau Proteins;Testing;Time;Transportation;United States;Vehicle crash;Visual;Visuospatial;way finding;Weather;Work

PROJECT_TITLE: Naturalistic driving as a functional neurobehavioral marker of preclinical and symptomatic Alzheimer disease


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative This prospective, longitudinal study follows monolingual English- and monolingual Spanish-speaking toddlers born preterm from birth to 18 months of age (corrected for prematurity) to explore the unique and overlapping contributions of social-environmental and neurobiological factors on the development of language processing efficiency, a skill with short- and long-term consequences for learning. Social-environmental predictors are assessed through day-long naturalistic audio recordings and laboratory observations of caregiver-child interactions while neurobiological predictors are measures of brain white matter, assessed through two complementary methods of structural neuroimaging. The results will contribute to our theoretical understanding of the pathogenesis of impairment after preterm birth and to identirication of targets and strategies for intervention in infancy to improve long-term language outcomes in this and other at-risk populations.

PI_NAMEs: FELDMAN, HEIDI M. (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Advanced Development;adverse outcome;Age;Age Months;Axon;Brain;brain magnetic resonance imaging;Caregivers;Child;Child Language;Clinical;clinical practice;Development;Early identification;Early Intervention;educational atmosphere;Enrollment;Environment;Environmental Risk Factor;experience;extreme prematurity;Eye;Family;Funding;gaze;Grant;Hearing;high risk;Human;Impairment;improved;infancy;Infant;Intervention;Laboratories;Language;language comprehension;Language Development;language outcome;language processing;Language Tests;Learning;Learning Disorders;Link;longitudinal, prospective study;low socioeconomic status;Measures;Mediating;Methods;Modeling;mortality;MRI Scans;Myelin;Names;Neonatal;neonatal period;neonate;Neurobiology;neuroimaging;non-verbal;Outcome;Outcome Measure;outcome prediction;Parents;Pathogenesis;Pathway interactions;Pediatric Hospitals;Performance;Population Heterogeneity;Populations at Risk;Pregnancy;premature;Premature Birth;preterm newborn;primary outcome;processing speed;programs;Property;Reaction Time;Reporting;Risk;Sampling;Scanning;secondary outcome;skills;social;Spanish;Spanish/English;Speech;Standardization;Structure;Survivors;Testing;Time;Toddler;Variant;verbal;visual tracking;Vocabulary;white matter;white matter change

PROJECT_TITLE: Predicting language processing efficiency in preterm children: Social-environmental and neuro-biological factors

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Infectious Diseases;Lung

ORG_CITY: NEW ORLEANS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Studies proposed in this revised competitive renewal application seek to define a new function for IL-33 and lipoxygenases in regulating the production of bioactive lipids in the lung during fungal infection.

PI_NAMEs: STEELE, CHAD  (contact)

PROGRAM_OFFICER_NAME: MONGODIN, EMMANUEL FRANCK

PROJECT_TERMS: Acids;Alveolar;alveolar type II cell;Amplifiers;Arachidonate 15-Lipoxygenase;Arachidonate 5-Lipoxygenase;Aspergillus fumigatus;Asthma;Attention;Biological Products;Biology;Bone Marrow;Cells;Cellularity;Chronic Obstructive Pulmonary Disease;Colitis;Cytochrome P450;cytokine;Data;Dendritic Cells;design;Development;Dinoprost;Dinoprostone;Disease;Eicosanoids;Enzymes;Epithelial Cells;Epithelium;Flow Cytometry;Funding;gastrointestinal;Generations;helminth infection;Host Defense;Human;Hydroxyeicosatetraenoic Acids;IL17 gene;Immune;Immune response;Immunity;Immunocompromised Host;Immunohistochemistry;immunoregulation;immunosuppressed;Impairment;in vivo;Individual;Infection;Inflammatory;Inflammatory Response;interleukin-22;ITGAX gene;lipid mediator;lipidome;lipidomics;Lipids;Lipoxygenase;LOX gene;LoxP-flanked allele;Lung;Lung Diseases;Lung infections;Mediating;Molds;Mus;Mycoses;Myelogenous;Myeloid Cells;neutrophil;novel;Outcome;Pathway interactions;Population;Predisposition;Production;Prostaglandin D2;Prostaglandins;Psoriasis;Receptor Signaling;Recombinants;Regulation;Reporter;Reporting;response;Role;Signal Transduction;Source;Structure of parenchyma of lung;therapeutic target;Work

PROJECT_TITLE: Biology of innate IL-22 during lung fungal infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-N(03)]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Palliative Care

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE/RELEVANCE Though episodes of lucidity (EL) in Alzheimer’s disease and related dementia (ADRD) which are reported to occur near end of life, have significant implications for care, they are poorly understood due to underdeveloped methodological approaches for capturing and measuring these events. We propose to address these gaps through longitudinal audiovisual observation among persons with ADRD surrounding end of life to inform data- driven definitions for EL, distinguish these events from routine fluctuations in ADRD, and establish a repository of observational data for future research. Herein, our long-term objective is to clarify conceptual, operational and epidemiologic understandings of EL in ADRD and our short-term objective is to establish the needed preliminary data and infrastructure to enable systematic investigation of EL, and thus further this long-term goal.

PI_NAMEs: GILMORE-BYKOVSKYI, ANDREA L (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;advanced disease;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Attitude;Behavior;behavioral response;Caring;Clinical;Code;Cognitive;cognitive function;Communication;complex data;Computational Linguistics;Data;Data Collection;data infrastructure;data platform;data repository;data sharing;Data Sources;Dementia;Development;Disease Progression;end of life;end of life care;Enrollment;Epidemiology;Ethics;Event;Eye;Family Caregiver;Feasibility Studies;Focus Groups;Foundations;Frequencies;Future;gaze;Goals;hospice environment;Individual;Infrastructure;Inpatients;interest;Interview;Investigation;Language;Legal;Linguistics;Measurement;Measures;Methodology;Methods;Mission;non-verbal;Nonverbal Communication;Output;Persons;Phase;Phenotype;Population;Privacy;Procedures;prospective;prototype;recruit;Reporting;repository;Research;Research Priority;Secure;sharing platform;Source;Speech;Standardization;Structure;Target Populations;United States;usability;Validation;Variant;verbal;Work

PROJECT_TITLE: Characterizing Episodes of Lucidity in Dementia Using Observational and Applied Computational Linguistics Approaches


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Supervised exercise therapy (SET) is recommended by practice guidelines as first line therapy for people disabled by lower extremity peripheral artery disease (PAD). However, travelling to an exercise center three times weekly for exercise is burdensome and few people with PAD participate in SET. In addition, 45% of people with PAD do not respond to walking exercise interventions. This study will use a Sequential Multiple Assessment Randomized Trial (SMART) to test whether our home-based exercise intervention that incorporates behavioral change methods improves 6-minute walk more than SET at 12-week follow-up and whether biologic augmentation of exercise with nitrate-rich beetroot juice significantly helps patients with PAD who are initially unresponsive to exercise attain gains in walking performance.

PI_NAMEs: MCDERMOTT, MARY MCGRAE (contact)

PROGRAM_OFFICER_NAME: RICE, ELISE

PROJECT_TERMS: Address;attentional control;Behavioral;Biological;Characteristics;Classification;Clinical;Clinical Trials;Control Groups;Disabled Persons;Enrollment;evidence based guidelines;Exercise;exercise intensity;exercise intervention;Exercise Therapy;Exercise Tolerance;Failure;follow-up;Gait abnormality;Guidelines;Health Personnel;Home;improved;improved mobility;Ischemia;Isolated limb perfusion;Juice;Leg;Lower Extremity;Measures;Medicare;meter;Methods;Muscle function;Nitrates;Nitrites;Older Population;optimal treatments;Participant;Patients;Peripheral arterial disease;Persons;phase II trial;Placebos;Plasma;Practice Guidelines;Randomized;randomized trial;Recommendation;Reporting;Research Design;responders and non-responders;Skeletal Muscle;standard of care;Symptoms;Testing;Time;Travel;treadmill;trial design;Walking;walking performance;Work

PROJECT_TITLE: Sequential Multiple Assessment Randomized Trial of Exercise for PAD: SMART Exercise for PAD

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Kidney Disease;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

PHR: Project Narrative During the progression of most chronic kidney diseases the structure and function of the glomerular filtration barrier (GBF) is irreversibly damaged. We propose to study the mechanisms that regulate podocyte injury. Re- establishing GFB function by stimulating podocyte survival could slow kidney disease progression and help the development of novel therapeutics for glomerular kidney disease.

PI_NAMEs: DA SACCO, STEFANO ;PERIN, LAURA  (contact)

PROGRAM_OFFICER_NAME: GOSSETT, DANIEL ROBERT

PROJECT_TERMS: Affect;Amniotic Fluid;Binding;Biology;Cell Cycle;Cell Cycle Progression;Cell Cycle Stage;cell injury;Cell Physiology;Cell Survival;Cells;Chronic Kidney Failure;Data;delivery vehicle;Deposition;design;Deterioration;Development;Disease Progression;End stage renal failure;Endothelial Cells;Etiology;Evaluation;Event;Experimental Models;Fluorescence;Foundations;Functional disorder;Genes;glomerular basement membrane;glomerular endothelium;glomerular filtration;glomerular function;Goals;Hereditary nephritis;Human;In Vitro;in vivo;inhibitor;inhibitor therapy;Injury;Injury to Kidney;innovation;insight;Integrin alphaVbeta3;Kidney;Kidney Diseases;knock-down;Knowledge;Lead;Maintenance;Methods;Micelles;Modeling;Molecular;Morphology;mouse model;Mus;nanoparticle;Normal Cell;novel;novel therapeutics;osteopontin;Pathway interactions;Patients;peptide amphiphiles;Phase;podocyte;prevent;progenitor;programs;Regulation;Renal function;Renal glomerular disease;repaired;Research;Role;Scheme;Series;Signal Transduction;standard of care;Structure;System;targeted delivery;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapeutic target;Transgenic Organisms;Ubiquitination;Up-Regulation;Vascular Endothelial Growth Factors;Work;WT1 gene

PROJECT_TITLE: Mechanisms involved in podocyte damage in Alport Syndrome

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: COLUMBIA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Public Health Relevance This project aims to identify new brain connections that can be targeted with brain stimulation and potential drug targets in the brain which can be used to decrease response to stressful, aversive stimuli. These potential therapeutic targets may be used to prevent or suppress symptoms observed in maladaptive fear, anxiety, and mood disorders.

PI_NAMEs: FRANCIS, TANNER CHASE (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TERMS: Anxiety;Anxiety Disorders;Association Learning;Attention;Automobile Driving;Aversive Stimulus;Behavior;Behavioral;Brain;Brain region;Calcium;career;cell type;Cells;Chemosensitization;cholinergic;cholinergic neuron;Classification;clinically relevant;conditioned fear;conditioning;Cues;Data;density;Disease;Dopamine;Drug Targeting;Electrophysiology (science);Emotional;experimental study;Exposure to;fear memory;Fiber;FOS gene;Foundations;Freezing;Fright;Future;Genetic;Genetic Identity;Glutamates;Homosynaptic Depression;Image;In Situ Hybridization;in vivo;in vivo imaging;Interneurons;Knock-out;Learning;Long-Term Potentiation;Maps;Mediating;memory recall;Modeling;Mood Disorders;Mus;Neurons;Nucleus Accumbens;optogenetics;Outcome;outcome prediction;Peptides;Phase;Phenotype;Photometry;Post-Traumatic Stress Disorders;prevent;Procedures;Protocols documentation;public health relevance;receptor;response;Role;Shock;Signal Transduction;Slice;Stimulus;Stress;Substance P;Symptoms;Synapses;System;TACR1 gene;Testing;Therapeutic;therapeutic target;Training;transmission process;Work

PROJECT_TITLE: Substance P-Mediated Enhancement of Salience for Cues Predicting Aversive Outcomes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE AMPA receptors mediate fast communication between neurons, contribute to high cognitive functions, and are implicated in numerous neurological diseases, including Alzheimer’s disease, amyotropic lateral sclerosis, epilepsy, and ischemia. We plan to use single-particle cryo-electron microscopy combined with protein biochemistry and electrophysiology to study AMPA receptors, their complexes with auxiliary subunits, and the mechanisms of activation and desensitization. Our studies will advance understanding of the molecular basis of excitatory neurotransmission and provide knowledge essential for the future structure-based drug design.

PI_NAMEs: SOBOLEVSKY, ALEXANDER  (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Agonist;Alzheimer's Disease;AMPA Receptors;Amyotrophic Lateral Sclerosis;antagonist;Architecture;Area;Binding;Binding Sites;Biological Assay;Brain;Cells;Clinical;cognitive function;cognitive process;Communication;Complex;Coupling;Cryoelectron Microscopy;Crystallography;desensitization;design;Detection;DLG1 gene;Drug Design;Electrophysiology (science);Epilepsy;Family;Fluorescence;Future;Generations;Genes;genetic regulatory protein;Germ Cells;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;Homologous Gene;Individual;Ion Channel;Ischemia;Knowledge;Length;Ligand Binding Domain;Mediating;member;Membrane;Molecular;Molecular Conformation;Molecular Sieve Chromatography;nervous system development;Nervous System Disorder;Neurons;neurotransmission;novel therapeutics;Ozone;particle;patch clamp;Pathologic;Pharmaceutical Preparations;positive allosteric modulator;postsynaptic;Primary Lateral Sclerosis;Process;Protein Biochemistry;Protein Engineering;protein expression;Proteins;receptor;Receptor Activation;receptor binding;receptor function;Regulation;Reporting;Research;Resolution;response;Rest;Role;Signal Transduction;Site-Directed Mutagenesis;small molecule;structural determinants;Structural Models;Structure;success;Synapses;Synaptic Receptors;Synaptic Transmission;Technology;Testing;thermostability;trafficking;transmission process;Work;X-Ray Crystallography

PROJECT_TITLE: Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Although recent research has found that neighborhood contexts are associated with brain structure, function, and behavior in relation to executive function (EF) and emotional functioning, central questions remain as to the role of neighborhoods in developmental change in these systems during adolescence, whether neighborhood disadvantage may also increase vulnerability to the stress and school disruption of the COVID-19 pandemic, and the modifiable contextual factors that may protect against adversity and foster resilience. The proposed study will capitalize on the longitudinal Adolescent Brain and Cognitive Development (ABCD), as well as the staggered onset of the pandemic across waves of data collection in ABCD, which creates an innovative quasi- experimental design to address these questions. This study will thus identify potential neurodevelopmental pathways related to neighborhood disadvantage and COVID-19 as targets for intervention as well as modifiable contextual factors that can inform immediate policy and programmatic interventions across disciplines and the prevention of long-term sequelae and disparities for subsequent pandemics or disasters.

PI_NAMEs: HACKMAN, DANIEL A (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: 10 year old;Achievement;Address;Adolescence;Adolescent;Adolescent Development;Age;Attention;Behavior;behavior change;Behavioral;Brain;Buffers;burden of illness;Characteristics;Child;Child Development;Childhood;Cities;cognitive development;cohort;Collection;Communication;Communities;community burden;contextual factors;Country;COVID-19;COVID-19 burden;COVID-19 impact;COVID-19 pandemic;Data;Data Collection;Data Set;design;Development;Disadvantaged;Disasters;Discipline;Disparity;Economic Burden;Education;educational atmosphere;emotion regulation;Emotional;emotional functioning;Emotions;Enrollment;Environment;Equity;executive function;experience;Family;Fostering;gray matter;Health;health difference;health disparity;Health Promotion;Inequity;innovation;Intervention;life span;long-term sequelae;Longitudinal Studies;Measurement;Measures;Mental Health;multimodality;neighborhood disadvantage;Neighborhoods;Neurocognition;neurodevelopment;neuroimaging;Neurophysiology - biologic function;Outcome;outcome disparities;pandemic disease;Parents;Participant;Pathway interactions;Personal Satisfaction;Phase;physical conditioning;Policies;Population Study;Positioning Attribute;post-COVID-19;post-pandemic;pre-pandemic;Predisposition;Prevention;Prevention strategy;protective factors;public education;Public Health;public health intervention;Quasi-experiment;Reporting;Research;resilience;Rest;Risk;Risk Factors;Role;school disruption;Schools;Site;social determinants;Stress;stressor;Structure;Support System;System;Time;Variant;Youth

PROJECT_TITLE: Neighborhood characteristics and neurodevelopment:  Risk and protective factors, and susceptibility to stressors and school disruption during the COVID-19 pandemic

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Drug Abuse (NIDA only);Genetics;Human Genome;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Substance Misuse

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE The proposed research will investigate the role played by specific neurons within the brainstem in opioid- induced respiratory depression (OIRD). Neuronal circuits within the brainstem are critical for maintaining breathing rhythms, and many of these neurons are severely impacted by opioid consumption, as they express opioid receptors. Identifying functional markers expressed in the MOR-expressing neurons that specifically mediate OIRD will provide a stepping stone to developing novel therapeutic interventions that selectively rescue OIRD without altering analgesic effects of opioids.

PI_NAMEs: HAN, SUNG  (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Acute;addiction;Address;Affinity;Agonist;Amygdaloid structure;Analgesics;Anatomy;Animals;antagonist;Antidotes;Attenuated;Behavioral;Binding;Brain region;Brain Stem;Breathing;Candidate Disease Gene;candidate identification;Cause of Death;Cell Nucleus;cell type;Cells;Centers for Disease Control and Prevention (U.S.);Color;Constipation;Coupled;Death Rate;Dependence;Development;Disadvantaged;Dissection;Dizziness;druggable target;Economics;Emotions;experience;Fluorescent in Situ Hybridization;G-Protein-Coupled Receptors;Gene Expression Profile;Genes;Genetic;Goals;Half-Life;Human;illicit opioid;Imaging Techniques;Injections;Knockout Mice;Label;Lateral;Ligands;Mediating;Mediator;misuse of prescription only drugs;Molecular;Monitor;Morphine;morphine administration;mRNA Differential Displays;mu opioid receptors;Mus;Naloxone;Nausea;neural;neural circuit;neuromechanism;neuronal circuitry;Neurons;new therapeutic target;novel;novel therapeutic intervention;Opioid;Opioid Analgesics;Opioid Antagonist;opioid mortality;Opioid Receptor;opioid use;Pain;pain perception;pain processing;parabrachial nucleus;Pathogenesis;Persons;pharmacologic;Physiological;Play;Population;preBotzinger complex;prescription opioid;Procedures;Proteins;Public Health;rate of change;receptor;Recreation;Regulation;Research;respiratory;Role;Sedation procedure;segregation;side effect;single-cell RNA sequencing;social;Sorting;Techniques;Testing;therapeutic target;tool;transcriptome;transcriptomic profiling;transcriptomics;transmission process;treatment strategy;United States;Ventilatory Depression;welfare

PROJECT_TITLE: Transcriptomic single-cell profiling in breathing-specific parabrachial mu-opioid receptor neurons


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Osteoporosis

ORG_CITY: MONTREAL

ORG_COUNTRY: CANADA

ORG_FIPS: CA

ORG_NAME: CENTRE HOSPITALIER DE L'UNIVERSITE DE MONTREAL (UNIVERSITY OF MONTREAL HOSPITAL)

ORG_STATE: PQ

ORG_ZIPCODE: H2X 0A9

PHR: PROJECT NARRATIVE People living with HIV (PLWH) are aging and experience a greater risk of age-related illness such as cardiovascular diseases (CVDs), bone diseases and frailty that appear to manifest at an earlier age (premature aging). We have identified the novel human inflammatory cytokine IL-32 as a key factor associated with CVD. The objective of this proposal is to study the potential impact of IL-32 on bone health and frailty, which will likely establish the link between HIV-mediated inflammation and premature aging of organs other than those involved in the immune response.

PI_NAMEs: TREMBLAY, CECILE  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acceleration;Acids;Activities of Daily Living;adverse outcome;Age;age acceleration;age related;Age related comorbidities;Aging;aging related disease;antiretroviral therapy;Arterial Fatty Streak;Arthritis;atheroprotective;Atherosclerosis;Biological;Biological Aging;Biological Markers;Blood Vessels;Body Composition;bone;Bone Density;Bone Diseases;bone health;bone metabolism;Bone remodeling;Bone Resorption;calcification;Calcium;calcium metabolism;Cardiovascular Diseases;cardiovascular imaging;CD4 Positive T Lymphocytes;Cell Differentiation process;cell type;Cells;Chronic;cohort;Cohort Studies;Competence;Complex;Coronary artery;Cues;cytokine;Data;Deposition;Development;Disease;Elderly;Endothelial Cells;Epithelial Cells;Equilibrium;Event;experience;Exposure to;Fatty acid glycerol esters;frailty;Functional disorder;Funding;Future;Goals;gut dysbiosis;gut microbiome;Health;Heart;hexanoic acid;HIV;HIV Infections;Homeostasis;Human;IL18 gene;IL8 gene;immune activation;Immune response;Immune system;In Vitro;in vivo;Inflammation;Inflammation Mediators;Inflammatory;inorganic phosphate;insight;Interleukin-1 beta;Interleukin-6;Intervention;intestinal epithelium;Joints;latent HIV reservoir;Link;Measures;Mediating;Mediator;men;metabolome;novel;novel therapeutic intervention;Organ;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteoporosis;Participant;Pathogenesis;Pathway interactions;peripheral blood;Persons;Phenotype;Physiological;Plasma;Play;predictive marker;premature;Premature aging syndrome;Process;Protein Isoforms;response;Risk;risk stratification;Role;Sampling;sex;systemic inflammatory response;The Multicenter AIDS Cohort Study;therapeutic target;TNF gene;TNF-related apoptosis-inducing ligand;Up-Regulation;Vascular Endothelial Cell;Volatile Fatty Acids;Woman;women versus men;Women's Interagency HIV Study

PROJECT_TITLE: Role of IL-32 as a predictor and mediator of Premature Aging Phenotypes(PAP) in HIV infection.

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

ORG_STATE: CO

PHR: Veterans with traumatic brain injury (TBI) frequently experience insomnia, which can delay their recovery and cause disability. Growing evidence suggests that misalignment between the timing of circadian rhythms—the daily changes in physical and behavioral processes that help the body stay healthy— and desired sleep may contribute to insomnia after TBI. Measuring the timing of the body’s central clock is necessary for detecting and treating this circadian misalignment; however, practical methods of measuring circadian timing have only been tested in a few limited research and clinical groups. This project aims to test the feasibility of two novel methods for measuring circadian timing in the homes of Veterans with TBI and insomnia, as well as explore the relationships between circadian health, disability, and sleep. In doing so, this research will help develop personalized treatments for insomnia in Veterans with TBI, which may aid recovery and improve functioning.

PI_NAMEs: REIS, DANIEL JAMES (contact)

PROJECT_TERMS: actigraphy;Address;arm;Behavioral;Biological;Brain region;chronic pain;Chronotherapy;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythms;Clinical;Cognitive Therapy;Collection;comorbidity;cost;Data;design;Detection;Development;Devices;diaries;disability;Disability Evaluation;disability risk;Disabling;Disabling condition;Disease;Ensure;Etiology;evidence base;Evidence based treatment;experience;falls;Fatigue;feasibility testing;Functional impairment;functional improvement;functional independence;functional outcomes;Goals;Health;Healthcare;Home;Home environment;Hormones;Hour;Human;improved;Information Systems;Injury;Intervention;Interview;Label;Laboratories;Light;Link;Longitudinal Studies;mathematical model;Measurement;Measures;Medicine;Melatonin;Mental Depression;Methods;Mission;novel;Pain;Participant;Patient Outcomes Assessments;patient population;Patients;peer;Personal Satisfaction;personalized medicine;Phase;Population;Post-Traumatic Stress Disorders;Process;Production;Productivity;Provider;psychologic;psychosocial;Quality of life;Recording of previous events;Recovery;Recovery of Function;rehabilitation research;rehabilitation science;rehabilitative care;Reporting;Research;research and development;Risk;Saliva;saliva sample;Salivary;Sampling;Schedule;severe mental illness;Shipping;Sleep;Sleep disturbances;sleep onset;sleep regulation;Sleeplessness;Spinal cord injury;standard care;standard measure;Stroke;System;targeted treatment;Testing;Time;tool;Traumatic Brain Injury;Traumatic Brain Injury recovery;Veterans;Wrist

PROJECT_TITLE: Enhancing Precision Sleep Medicine in traumatic Brain Injury: Examining the feasibility of Home-Based Measurement of Circadian Timing

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Emergency Care;HIV/AIDS;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention;Primary Health Care

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE HIV pre-exposure prophylaxis (PrEP) uptake in Louisiana is among the lowest in the country, and few solutions have been developed to address the unique barriers to optimal PrEP uptake in the state. This project focuses on the use of machine learning algorithms embedded within the electronic health record (EHR) of large health systems in Southeastern Louisiana to identify persons at increased risk for HIV infection. The project will also evaluate approaches to best utilize the output from these algorithms to inform effective health-system based HIV risk status notification strategies on a population level, with input from community stakeholders.

PI_NAMEs: CLEMENT, MEREDITH EDWARDS;OKEKE, NWORA LANCE (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;acute care;Address;AIDS prevention;Algorithms;Area;Baptist Church;Big Data;candidate identification;Caring;Centers for Disease Control and Prevention (U.S.);Client;Clinical;Clinical Data;Communities;community empowerment;community organizations;Comprehensive Health Care;Country;Data;Development;Diagnosis;Disparity;Effectiveness;Electronic Health Record;Ensure;Epidemiological trend;Epidemiology;Evaluation;Event;Focus Groups;Foundations;Future;Guidelines;Health;health care delivery;Health care facility;Health Services Research;Health system;Healthcare;Healthcare Systems;high risk population;HIV;HIV Infections;HIV risk;Human Resources;implementation questions;implementation science;implementation strategy;implementation trial;Incidence;indicated prevention;Individual;innovation;insight;Interview;Link;longitudinal care;Louisiana;Machine Learning;machine learning algorithm;machine learning model;member;Methodology;Missionary;Modeling;multidisciplinary;Notification;novel strategies;Output;Periodicals;Persons;pilot trial;point of care;Population;pre-exposure prophylaxis;Precede-Proceed Model;predictive modeling;predictive tools;prevent;Primary Care;Public Health Informatics;Randomized;Readiness;Reporting;Risk;risk prediction;risk prediction model;scale up;Schedule;surveillance study;Testing;Time;tool;treatment as usual;trial comparing;uptake;urgent care;urgent care provider;US State;Work

PROJECT_TITLE: Leveraging Local Health System Electronic Health Record Data to Enhance PrEP Access in Southeastern Louisiana: A Community-Informed Approach


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alcoholism, Alcohol Use and Health;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative Alzheimer's Disease (AD) is a devastating neurodegenerative disorder without a cure. Using two mouse models representing familial and late-onset sporadic AD, we will investigate whether alcohol exposure has sex and/or age-dependent effect exacerbating the onset and development of AD. Our research will provide comprehensive data and critical biological evidence to establish the preclinical criteria and provide translatable information to clinical studies in regard to the impact of alcohol on AD.

PI_NAMEs: CHOI, DOO-SUP  (contact);TRUSHINA, EUGENIA

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 3-Dimensional;Address;Affect;Age;age related;age related decline;Alcohol consumption;alcohol effect;alcohol exposure;alcohol response;alcohol use disorder;Alcohols;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-Protein;APP-PS1;Autophagocytosis;Behavior;behavioral phenotyping;Biochemical;Biological;Biological Markers;Blood;Brain;Brain Injuries;brain tissue;Chronic;Clinical Research;Cognitive;cognitive function;Data;Dementia;Dendritic Spines;Development;Disease;disease phenotype;Disease Progression;Elderly;Electron Microscopy;epidemiology study;Ethanol Metabolism;Excitatory Postsynaptic Potentials;Face;familial Alzheimer disease;Female;field study;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;Functional disorder;Future;Genetic;genetic risk factor;Glucose;glucose metabolism;glucose uptake;Goals;Heavy Drinking;Hippocampus;Homeostasis;Human;Image;Impaired cognition;Impairment;in vivo;Individual;Inflammation;Inflammatory;Investigation;Laboratories;Late Onset Alzheimer Disease;Light;Magnetic Resonance Spectroscopy;male;Measures;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;metabolomics;mild cognitive impairment;Mitochondria;mitochondrial dysfunction;Modeling;Morphology;morris water maze;mouse model;Movement;Mus;Nature;Neurodegenerative Disorders;Neurons;novel;object recognition;Outcome;Oxidation-Reduction;Pathologic;Pathway interactions;Patients;Positron-Emission Tomography;pre-clinical;Predisposition;Proteins;proteostasis;reconstruction;Research;Risk;Sampling;sex;Sex Differences;sex risk;Slice;synaptic function;Testing;therapeutic target;validation studies;vapor;Woman

PROJECT_TITLE: Chronic Alcohol Exposure and Pathophysiology of Alzheimer's Disease.


ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: OVERALL PROJECT NARRATIVE In the 4.5 years since our initial award, we have established CHERISH (Center for Health Economics of Treatment Interventions for Substance Use Disorder, HCV, and HIV) as a National Center of Excellence for health economic research related to substance use disorder policy and HCV and HIV care of people who use substances. In this renewal period, we propose to expand our focus to add population data and modeling components, develop economic evaluation methodologies, and improve knowledge translation strategies for health outcomes and implementation research that is conducted at the individual, system, and community- levels. The Center includes 3 Scientific Cores (Methodology Core, Population Data & Modeling Core, and Dissemination & Policy Core) and 2 Supporting Cores (Pilot Grant & Training Core, Administrative Core).

PI_NAMEs: SCHACKMAN, BRUCE R (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: adaptive intervention;Address;advanced simulation;Area;Award;Caring;Clinical;Communication;Communities;comparative effectiveness study;Consultations;Data;Data Linkages;Data Set;design;Development;dissemination science;economic evaluation;Economics;Educational Curriculum;Ensure;Evaluation;Evaluation Methodology;Evaluation Research;experience;Funding Opportunities;Grant;Health;Health behavior;health care service utilization;health economics;Health system;Healthcare;Hepatitis C virus;HIV;HIV/HCV;implementation intervention;implementation research;implementation study;improved;Individual;Infrastructure;Institution;Integrated Health Care Systems;interest;Intervention;Knowledge;knowledge base;knowledge translation;Lead;Leadership;Link;Massachusetts;member;Mentors;Mentorship;Methodology;Methods;Modeling;models and simulation;novel strategies;Outcome;Outcomes Research;Participant;Persons;Policies;Policy Maker;Population;programs;Provider;Records;Research;Research Personnel;Research Project Grants;Research Support;Resources;Science;Scientific Advances and Accomplishments;Services;Structure;substance use;Substance Use Disorder;substance use treatment;symposium;System;tool;Training;Training Activity;Translating;translational approach;Treatment outcome;Work

PROJECT_TITLE: Health Economics of Substance Use Disorder, HCV, and HIV Treatment: Evaluating Intervention Outcomes for Individuals, Systems, and Communities


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: addiction;Area;Award;Boston;Caring;Clinical Research;cohort;Collaborations;collaborative environment;Communities;Consultations;Data;Discipline;Disease;dissemination science;Doctor of Philosophy;economic evaluation;Economics;Educational workshop;Ensure;Evaluation;Funding;Funding Opportunities;Grant;Health;Health behavior;health care service utilization;health economics;Health Services Research;Hepatitis C virus;HIV;HIV/HCV;implementation research;improved;Individual;innovation;Institution;interest;Internet;Intervention;knowledge translation;Leadership;Location;Medical center;medical schools;Medicine;meetings;Mentors;Methodology;Modeling;models and simulation;Monitor;multidisciplinary;Nature;network models;news;Newsletter;Online Systems;Opioid;Outcome;Outcomes Research;Pennsylvania;Persons;Policies;Population;Productivity;programs;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resources;Rotation;Science;Self-Examination;Services;skills;social media;Structure;substance use;Substance Use Disorder;success;Sum;symposium;System;Technology;Training;translational approach;United States National Institutes of Health;Universities;Update;virtual;web site

PROJECT_TITLE: Core 1: Administrative Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

PHR: Project Narrative While older women are disproportionately affected by chronic diseases and conditions associated with aging, including both physical and cognitive impairments, that can be alleviated or delayed by regular physical activity, few physical activity programs have been developed specifically with their needs in mind. This research aims to evaluate, in insufficiently active older women from the national WHISH pragmatic trial, the added effects of a technology-driven environmental barriers intervention called Our Voice compared to a “light-touch” remote educational program alone that has been delivered as part of WHISH. This study will add important information on the benefits and trade-offs of combining these remotely delivered and practical behavioral health delivery approaches to promote physical and cognitive health for the fast-expanding demographic group of U.S. older women.

PI_NAMEs: KING, ABBY C (contact);STEFANICK, MARCIA L.

PROJECT_TERMS: academic standard;Address;Adherence;Aerobic Exercise;Age;Age Years;age-related disease;Aging;arm;Automobile Driving;Behavior;Behavioral;behavioral health;Behavioral Medicine;caregiving;Cellular Phone;Chronic Disease;citizen science;Cognitive;cognitive benefits;cognitive function;Communication;Communities;Consent;contextual factors;dementia risk;Disparity;Disproportionately impacts women;Distance Education;Education;Educational Activities;Educational Intervention;Educational process of instructing;efficacy trial;Electronic Mail;Enrollment;Environment;Environmental Risk Factor;Ethnic Origin;exercise intervention;family support;Fostering;functional decline;Gender;Generations;Geographic Locations;Geography;guidebooks;handheld mobile device;Health;Health behavior change;Health Benefit;Health Care Costs;Impaired cognition;innovation;Internet;Intervention;Intervention Studies;Knowledge;Life Expectancy;lifetime risk;Light;Link;Malignant Neoplasms;Measures;Mediator;men;mobile application;Modeling;Motivation;Neighborhoods;Newsletter;novel;Observational Study;older men;older women;Online Systems;Participant;Patient Self-Report;pedometer;Persons;Physical activity;Physical Education;Physical Function;physical impairment;Population;pragmatic trial;Precision Medicine Initiative;Process;programs;Public Health;Race;Randomized;Regimen;relative cost;remote delivery;Research;Resources;response;Risk Factors;Sampling;Seasons;sedentary lifestyle;social;social cohesion;social culture;socioeconomics;success;Surveys;System;Technology;Telephone;Testing;Touch sensation;United States National Institutes of Health;Voice;walkability;Walking;way finding;web site;Woman;Women's Health

PROJECT_TITLE: Testing Multi-Level Remote Physical Activity Interventions in a National Sample of Older Women: The WHISH EnCore Trial

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Patient Safety;Prevention;Radiation Oncology

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE People with HIV (PWH) may have poorer cancer outcomes than people without HIV (HIV-), but few large studies have evaluated differences in specific cancer care delivery outcomes by HIV status. Within the Veteran's Administration and Kaiser Permanente, we will investigate reasons for disparities between PWH and matched HIV- persons in delays in cancer treatment initiation, completion and safety, as well as short- and long-term outcomes of cancer recurrences, mortality, and risk of chronic health conditions. Study findings have potential to identify intervention targets, inform HIV-specific cancer treatment guidelines, and improve cancer care delivery and outcomes for PWH.

PI_NAMEs: CHIAO, ELIZABETH Y.;SILVERBERG, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: DOMINGUEZ, GERALDINA

PROJECT_TERMS: Accounting;Acquired Immunodeficiency Syndrome;Address;Adverse event;Aftercare;Age;antiretroviral therapy;Antitumor Response;Anus;cancer care;cancer initiation;cancer recurrence;cancer risk;cancer survival;Cancer Survivor;cancer therapy;Cardiac;care delivery;care outcomes;care providers;Caring;Cause of Death;CD4 Lymphocyte Count;chemotherapy;Chronic;Clinical Trials;common treatment;comorbidity;Data;data resource;demographics;Diagnosis;Disease;Disparity;dosage;Dose;Electronic Health Record;Etiology;Event;Exclusion;General Population;Goals;Head and Neck Cancer;Health;Health system;high risk;HIV;HIV diagnosis;HIV Infections;Hospitalization;Immune system;Immunologics;Immunosuppression;improved;improved outcome;Institution;Integrated Health Care Systems;Intervention;Kidney;Knowledge;Late Effects;Life Expectancy;Lung;Lymphocyte;Lymphopenia;Malignant neoplasm of anus;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical Oncologist;Metabolic;mortality;mortality risk;Neck Cancer;neutrophil;Non-Small-Cell Lung Carcinoma;novel;observational cohort study;Outcome;Patients;Persons;Process;provider factors;Publishing;Radiation Oncologist;Radiation therapy;Recovery;Recurrence;Regimen;Risk;Risk Factors;Safety;Sampling;Second Primary Cancers;Serious Adverse Event;Single-Payer System;Site;study population;survival disparity;survivorship;therapy outcome;Toxic effect;treatment disparity;treatment guidelines;United States;United States Department of Veterans Affairs

PROJECT_TITLE: (PQ3) Addressing Cancer Treatment Disparities for Persons with HIV


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Cost Effectiveness Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse

PI_NAMEs: MURPHY, SEAN M. (contact)

PROJECT_TERMS: Accounting;adaptive intervention;Address;Adoption;Applications Grants;Area;budget impact;Caring;Chronic Disease;Clinical;Collaborations;Communities;comparison intervention;Consultations;cost;cost effectiveness;Cost Savings;Cost-Benefit Analysis;Costs and Benefits;Data;data integration;Data Set;design;Development;Disease;Doctor of Philosophy;economic evaluation;economic impact;Economics;Effectiveness;Ensure;Equilibrium;Evaluation Methodology;evidence base;Evidence based practice;Evidence based treatment;Goals;Health;health economics;Hepatitis C virus;HIV;HIV/HCV;implementation framework;implementation intervention;implementation research;improved;Individual;individual patient;Interdisciplinary Study;Intervention;intervention cost;Life Expectancy;Link;long term recovery;Measures;Methodology;Methods;Modeling;multidisciplinary;novel strategies;online community;Outcome;Outcomes Research;Persons;Play;Policies;Policy Maker;Population;Procedures;Productivity;programs;Protocols documentation;Provider;Qualifying;Quality of life;Records;Recovery;Recovery Support;Research;Research Personnel;Research Support;Resource Allocation;Resources;Role;Schools;Services;sound;stakeholder perspectives;substance use;Substance Use Disorder;substance use treatment;System;therapy development;Time;tool;Treatment Cost;treatment program;Update;uptake;Work

PROJECT_TITLE: Core 2: Methodology


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Substance Misuse

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative A better understanding of the prevalence and co-occurrence of relatively common comorbidities among children and adolescents with prenatal alcohol exposure (PAE) is essential in order to intervene in clinically meaningful ways. These complex comorbid conditions are often the most challenging, disruptive, and costly health issues that families with a child affected by alcohol must cope. This study will document the prevalence and co- occurrence of early-stage indicators of possible or probable future chronic disease in children/adolescents with PAE.

PI_NAMEs: CHAMBERS, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: DUNTY, JR, WILLIAM

PROJECT_TERMS: 10 year old;14 year old;4 year old;Address;Adolescent;Adult;adverse childhood events;Affect;Age;age group;Alcohols;Anxiety;Atherosclerosis;Autoimmune Diseases;Biological Assay;Birth;Blood capillaries;Blood specimen;Burn injury;capillary bed;Cardiovascular Diseases;Cardiovascular Manifestation;Caregivers;Categories;Characteristics;Child;Child health care;Childhood;Chronic Disease;Clinical;Clinical Data;cohort;Cohort Studies;Collaborations;Communities;comorbid depression;comorbidity;Complex;coping;Core Facility;Data;developmental disease;Diabetes Mellitus;Diagnosis;Diagnostic;Diet Habits;Dietary intake;Disease;disease classification;Eating Behavior;Evaluation Studies;Family;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;fetal diagnosis;Future;Goals;Growth;Guidelines;Health Care Costs;Health system;Hearing;Hyperlipidemia;Hypertension;Impaired cognition;impaired glucose tolerance;improved;Individual;Inflammation;inflammatory marker;Insulin Resistance;Intervention;iron deficiency;Knowledge;Laboratories;Length;Life;Life Cycle Stages;life span;Longitudinal cohort study;Measurement;Measures;Mediating;Mental Depression;Metabolic;MicroRNAs;Myocardial dysfunction;Nail plate;Outcome;Participant;Pattern;Physical activity;pre-clinical;Premature aging syndrome;prenatal;Prevalence;prevent;Prevention;Probability;Recommendation;recruit;remediation;Research;research clinical testing;Research Personnel;Resources;Sample Size;Sampling;Signs and Symptoms;Sleep;Sleep disturbances;Structure;Telemedicine;telomere;Telomere Shortening;Three-Dimensional Image;Translating;Ukraine;Vision;Work

PROJECT_TITLE: Whole Body Effects of PAE Across the Life Span: Early Markers of & Clinical Interventions for Children and Adolescents in Ukraine


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Chronic Liver Disease and Cirrhosis;Cost Effectiveness Research;Data Science;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Address;aged;Bacterial Infections;Big Data;British Columbia;career;Caring;Cessation of life;Chronic;Clinical;cohort;Cohort Studies;Collaborations;Communication;Communities;comparative effectiveness study;Complement;Coupled;Data;data modeling;data repository;Data Set;Databases;Dimensions;Disease Outbreaks;Doctor of Philosophy;Drug usage;economic evaluation;economic value;Economics;eHealth;Electronic Health Record;Epidemic;Epidemiology;Face;follow-up;Generations;Group Meetings;Health;health economics;Health Insurance;Hepatitis C;Hepatitis C Incidence;Hepatitis C Transmission;Hepatitis C virus;HIV;HIV Infections;HIV/AIDS;HIV/HCV;implementation research;Individual;Injecting drug user;injection drug use;insight;Intervention;Knowledge;Label;Lead;Life Expectancy;Link;Manuscripts;Massachusetts;Measures;Medical;meetings;Methodology;Methods;Mission;Modeling;models and simulation;Monitor;Natural History;Nature;opioid epidemic;opioid use disorder;Outcome;Outcomes Research;Overdose;overdose death;Persons;Pharmacy facility;Policies;Policy Maker;Policy Making;Population;Positioning Attribute;premature;Prevalence;Prospective Studies;Publishing;randomized trial;Records;Research;Research Design;Research Personnel;Resources;response;Services;Soft Tissue Infections;stimulant use;substance use;Substance Use Disorder;success;syndemic;System;Time;tool;Translating;transmission process;Treatment Effectiveness;Treatment outcome;Universities;Work;working group

PROJECT_TITLE: Core 3: Population & Data Modeling


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: K.220.8: PROJECT NARRATIVE Failure to resolve sources of phenotypic and genetic heterogeneity within AUD obscures efforts to understand its distal and proximal correlates, sequelae, and treatment implications. This research will draw on a combination of cross-sectional and longitudinal phenotypic and genetically-informative data to (1) characterize sources of phenotypic and genetic heterogeneity within AUD and (2) delineate its specific interface with other psychopathology, in turn ascertaining its unique and transdiagnostic features, putative underlying mechanisms, and interface with other psychopathology. Findings will elucidate major domains undergirding AUD and characterize specific AUD vulnerabilities, which will inform future precision medicine efforts.

PI_NAMEs: WATTS, ASHLEY L. (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: addiction;Adopted;Alcohol consumption;Alcohol dependence;alcohol misuse;alcohol research;alcohol use disorder;Animal Model;Award;Behavior Control;Behavioral Genetics;Biological;Brain;career;comorbidity;Consultations;craving;Data;Data Analyses;Data Set;Dedications;Detection;Diagnosis;Diagnostic;diagnostic criteria;Dimensions;disease classification;Distal;Educational workshop;Equation;Etiology;Failure;Functional disorder;Future;Genetic;genetic analysis;genetic architecture;Genetic Heterogeneity;Genetic Techniques;genome wide association study;Genomics;Genotype;Heterogeneity;Human;improved;incentive salience;Individual Differences;Institution;interest;Intervention;Knowledge;Manuscripts;Maps;Mentors;Mentorship;Methods;Missouri;Modeling;Modernization;Molecular Genetics;National Institute on Alcohol Abuse and Alcoholism;negative affect;neurobehavioral;neurobiological mechanism;Neurobiology;Neurosciences;Pathway interactions;person centered;Persons;Phase;Phenotype;Postdoctoral Fellow;precision medicine;Preparation;Process;Prognosis;psychologic;Psychopathology;Quantitative Genetics;Registries;Research;Research Activity;Research Domain Criteria;Research Personnel;Resources;Rewards;Role;Science;Scientist;Severities;skills;Source;Specificity;substance use;Supervision;symposium;Symptoms;Syndrome;Time;Training;Training Activity;Twin Multiple Birth;Universities;Wood material;Work

PROJECT_TITLE: Resolving sources of heterogeneity and comorbidity in alcohol use disorder


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Digestive Diseases;Dissemination and Implementation Research;Drug Abuse (NIDA only);HIV/AIDS;Health Services;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse

PI_NAMEs: MEISEL, ZACHARY FRANKLIN (contact)

PROJECT_TERMS: Address;Attention;Caring;Clinical;clinical care;Clinical Research;cohort;Collaborations;Communication;Communities;Complex;Consultations;cost;Data;design;dissemination research;dissemination science;Doctor of Philosophy;economic evaluation;Economic Policy;Economics;Educational Curriculum;Educational workshop;Ensure;Environment;experience;Grant;health economics;Health Policy;health service use;Health Services;health training;Hepatitis C virus;HIV;HIV/HCV;implementation research;improved;Individual;innovation;Intervention;Knowledge;knowledge base;knowledge translation;Leadership;Learning Module;Mass Media;meetings;member;Methodology;Methods;Modeling;Needs Assessment;opioid use disorder;Outcome;Outcomes Research;Participant;Pennsylvania;Persons;pilot test;Policies;Policy Maker;Policy Making;Policy Research;Population;Process;Public Health;Research;Research Design;Research Personnel;Role;service delivery;Services;skills;substance use;Substance Use Disorder;substance use treatment;symposium;System;theories;Time;tool;Training;Translating;Translations;Universities;Update;Work

PROJECT_TITLE: Core 4: Dissemination & Policy


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cost Effectiveness Research;Digestive Diseases;Drug Abuse (NIDA only);HIV/AIDS;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Social Determinants of Health;Substance Misuse

PI_NAMEs: ADEN, BRANDON  (contact)

PROJECT_TERMS: Address;Aden;Applications Grants;Archives;Area;Award;career;Caring;cohort;Collaborations;Communities;community intervention;Country;Data;Data Collection;Development;dissemination science;economic evaluation;Economics;Educational workshop;Ensure;experience;Funding;Grant;Health;health economics;Health Policy;Hepatitis C virus;HIV;HIV/HCV;Individual;innovation;Institution;Intervention;Intervention Studies;Investigator-Initiated Research;K-Series Research Career Programs;meetings;Mentors;Mentorship;Methodology;Methods;Modeling;novel;Outcome;Pennsylvania;Persons;Pilot Projects;Policies;Population;Process;programs;Publications;randomized trial;recruit;Research;Research Personnel;Research Project Grants;research study;skills;Structure;Students;substance use;Substance Use Disorder;substance use treatment;symposium;System;Teacher Professional Development;tool;Training;Training Activity;Training Programs;Universities;virtual library;web site;Work

PROJECT_TITLE: Project 1: Pilot Grant and Training Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

ORG_CITY: TORONTO

ORG_NAME: UNIVERSITY HEALTH NETWORK

ORG_STATE: ON

ORG_ZIPCODE: M5G 2C4

PHR: The North American Star Consortium for UM1 ETCTN trials consists of leading investigators from the Moffitt  Cancer Center, Princess Margaret Cancer Centre, VCU-Massey Cancer Center, University of Texas  Southwestern Simmons Cancer Center and Northwestern University Lurie Cancer Center. This consortium is  focused on producing and enrolling patients on high-quality clinical trials to significantly impact cancer  outcomes, the incorporation of state-of-the-art precision science in the trials, the accrual of minority,  underserved, elderly, and adolescent and young adult patients, and training the next generation of physician  researchers in cancer drug development.

PI_NAMEs: BEDARD, PHILIPPE  (contact);COURTNEY, KEVIN D;GRANT, STEVEN ;LANCET, JEFFREY ;MAHALINGAM, DEVALINGAM ;SIU, LILLIAN L

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Address;Adherence;Adolescent and Young Adult;American;Antineoplastic Agents;Award;Biological Markers;biomarker development;Cancer Center;Cancer Therapy Evaluation Program;career;career development;Catchment Area;Clinical;Clinical Investigator;Clinical Research;Clinical Trials;Contracts;demographics;Development;Disease;drug development;Drug Kinetics;early phase clinical trial;early phase trial;Early Therapeutic-Clinical Trials Network;Education;Elderly;Enrollment;Goals;Good Clinical Practice;Grant;Guidelines;human subject protection;Image;improved;inner city;Institution;Intervention;investigator-initiated trial;Laboratories;Lead;Malignant Neoplasms;member;Mentors;Mentorship;Minority;Minority Groups;minority patient;Molecular Analysis;Monitor;next generation;novel;Outcome;participant enrollment;Pathologist;Patients;Pharmacodynamics;Phase;phase II trial;Physicians;precision oncology;Productivity;programs;Publications;radiologist;Regulation;Reporting;Request for Applications;Research Personnel;response;Rural Population;Science;Site;success;Texas;Time;Tissue Banks;tissue biomarkers;Toxic effect;Training;Translational Research;translational scientist;Tumor Tissue;Underserved Population;Universities;Virginia

PROJECT_TITLE: North American Star Consortium


ADMINISTERING_IC: TR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PI_NAMEs: MORONE, NATALIA E. (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Address;Award;Big Data;Boston;career;career development;Clinical;Collaborations;Communities;Community Health;Development;Discipline;Educational Curriculum;Faculty;Fostering;Funding;Future;Goals;Grant;Grant Review;Health;improved;innovation;Institution;Instruction;Investments;K-Series Research Career Programs;Mentors;Pathway interactions;post-doctoral training;Postdoctoral Fellow;Program Development;programs;Research;Research Personnel;Resources;Science;Scientist;skills;success;System;Teacher Professional Development;technological innovation;Technology;Training Programs;translational scientist;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Institutional Career Development


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Precision Medicine

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE Medical decisions in chronic diseases of older adults are becoming more complex as we learn to individualize targets and treatments based on clinical characteristics, genetic profiles, treatment preferences, and social circumstances. This award will allow Dr. Elbert Huang to devote 25% of his time to training the next generation of researchers in medical decision making and expand his research in epidemiology, pharmacoepidemiology, and decision support interventions. Improving the quality of medical decision making in chronic diseases of older adults has the great potential to improve the quality of life of patients.

PI_NAMEs: HUANG, ELBERT S. (contact)

PROJECT_TERMS: Address;Advanced Development;Affect;Aging;Architecture;Award;Benefits and Risks;California;Cardiovascular system;Caregivers;Caring;Characteristics;Chicago;Chronic;Chronic Disease;Clinical;clinical implementation;clinical practice;Clinical Research;cohort;Cohort Studies;Complex;Complications of Diabetes Mellitus;Computerized Medical Record;Consolidated Framework for Implementation Research;Cost Analysis;cost effectiveness;Cost Effectiveness Analysis;Data;Data Collection;data repository;Decision Aid;Decision Making;Dementia;design;Development;diabetes management;Diabetes Mellitus;diabetic;Disease Management;Documentation;Elderly;End stage renal failure;Environment;Epidemiology;Evaluation;Event;field study;Foundations;Future;Genetic;Glucose;Glycosylated hemoglobin A;Goals;Guidelines;Health;Health and Retirement Study;Heterogeneity;human centered design;Hypoglycemia;improved;Individual;individual patient;insight;interdisciplinary collaboration;interest;International;Intervention;Kidney;Learning;Life;Longitudinal cohort;Mathematical Model Simulation;Medical;Medicare claim;Medicare/Medicaid;Medicine;Mentorship;Methodology;Mid-Career Clinical Scientist Award (K24);Modeling;models and simulation;mortality;multi-ethnic;next generation;non-diabetic;novel drug class;novel therapeutics;Nurses;Observational Study;older adult;older patient;Outcome;outcome prediction;patient engagement;patient population;Patient Selection;Patients;personalized approach;personalized care;personalized intervention;Pharmaceutical Preparations;Pharmacoepidemiology;Population;Population Heterogeneity;practice-based research network;Prediabetes syndrome;predictive modeling;preference;primary endpoint;Process;professor;programs;prospective;prototype;Quality of life;Randomized;Recording of previous events;Reduce health disparities;Registries;Research;Research Personnel;Resources;response;Risk;Risk Factors;secondary endpoint;Selection for Treatments;Series;Shapes;social;Social Functioning;social relationships;Social Sciences;support tools;Testing;therapy development;Time;tool;Training;Treatment Protocols;treatment response;United Kingdom;Universities;Update;Variant

PROJECT_TITLE: Research and Mentorship in Medical Decision Making for Chronic Diseases of Older Adults

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Patient Safety;Prevention

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Project Narrative: The development of perioperative stress hyperglycemia in patients without a known history of diabetes undergoing general surgery is a significant predictor of hospital complications and mortality. The likelihood of developing stress hyperglycemia is amplified in the presence of underlying dysglycemia, including prediabetes and undiagnosed diabetes. This proposal seeks to identify and characterize patients at greatest risk of developing hyperglycemia postoperatively in order to target hyperglycemia prevention in a high-risk population and improve hospital outcomes related to suboptimal glycemic control.

PI_NAMEs: DAVIS, GEORGIA M (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;adiponectin;Advisory Committees;Age;Agonist;Anti-diabetic Drugs;Beta Cell;Biological Markers;Biometry;Blood Glucose;blood glucose regulation;Blood Vessels;Body mass index;C-reactive protein;Cardiac;career;career development;Cell Physiology;Cessation of life;Characteristics;Clinical;Clinical Investigator;clinical predictors;Clinical Trials;Collaborations;comparison control;Continuous Glucose Monitor;cost;Development;Development Plans;diabetes management;Diabetes Mellitus;Dose;Event;experience;GLP-I receptor;Glucose;glucose monitor;glycemic control;Glycosylated hemoglobin A;Goals;Guidelines;high risk;high risk population;Hormones;Hospital complications;Hospital Mortality;Hospitalization;Hospitals;human old age (65+);Hydrocortisone;Hyperglycemia;Hypoglycemia;Iatrogenesis;improved;Incidence;Individual;infection rate;Inflammation;Inflammatory;Inpatients;Institution;Insulin;Insulin Resistance;insulin secretion;insulin sensitivity;Interdisciplinary Study;intravenous administration;Measures;Mentorship;Metabolic;Modeling;mortality;Newly Diagnosed;Nonesterified Fatty Acids;OGTT;Operative Surgical Procedures;Outcome;Oxidative Stress;Patients;Perioperative;Perioperative complication;Pilot Projects;Placebos;Pneumonia;point of care;Postoperative Period;Prediabetes syndrome;Predisposition;Prevention;primary endpoint;profiles in patients;prospective;Prospective Studies;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Reporting;Research;Research Training;Respiratory Failure;Retrospective Studies;Risk;Risk Factors;risk prediction model;risk stratification;secondary endpoint;sensor;Severities;standard of care;Stress;subcutaneous;Technology;Testing;Thiobarbituric Acid Reactive Substances;Time;TNF gene;Training;Work;Wound Infection

PROJECT_TITLE: Perioperative Stress Hyperglycemia in General and Vascular Surgery Patients

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Pediatric;Prevention;Serious Mental Illness;Sleep Research

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative Bipolar disorder is a severe and chronic illness associated with significant functional impairment, enormous public health costs, and high rates of suicide. Offspring of parents with bipolar disorder are a particularly high- risk group who typically display early onset and severe course of illness. Thus, effective and readily disseminable early assessment and intervention for the children of parents with bipolar disorder focused on specific, readily measurable, and modifiable risk factors has the potential to prevent or ameliorate the progression of bipolar disorder in those at highest risk.

PI_NAMEs: GOLDSTEIN, TINA R (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: actigraphy;Adolescence;adolescent offspring;Adult;Advisory Committees;Affect;Affective;Age;anxiety symptoms;Area;Behavior;Biological Markers;Bipolar Disorder;Brain Diseases;Cellular Phone;Child;Chronic;Chronic Disease;circadian;Circadian Dysregulation;Circadian Rhythms;Clinical;Clinical assessments;Communities;confirmatory trial;cost effective;cost effective measures;Data;Data Collection;depressive symptoms;Development;diaries;Dimensions;Disease;disorder risk;early experience;Early Intervention;early onset;efficacious intervention;efficacy evaluation;Evidence based intervention;Evidence based treatment;Exhibits;Family;Family member;Feedback;Functional impairment;Health Care Costs;healthy lifestyle;high risk;high risk population;Impairment;implementation science;improved;improvement on sleep;indicated prevention;Individual;innovation;Intake;Intervention;Investigational Therapies;Manic;Manuals;Measurable;Measures;Mediating;Meta-Analysis;Methods;modifiable risk;Mood Disorders;Moods;Morbidity - disease rate;National Institute of Mental Health;novel strategies;offspring;Onset of illness;Outcome;Outcome Study;Parents;Participant;Pathway interactions;Patient Self-Report;Pattern;portability;preempt;prevent;Prevention;Prevention approach;primary outcome;programs;progression risk;psychiatric symptom;Psychopathology;Public Health;Randomized;randomized trial;Recording of previous events;Reporting;Research;Risk;Risk Factors;Role;Secure;Severity of illness;Signal Transduction;Sleep;Sleep disturbances;social;Strategic Planning;Stress;substance use;suicidal;Suicide;suicide rate;Symptoms;telehealth;Telephone;Testing;theories;Time;tool;treatment adherence;treatment optimization;treatment response;videoconference;Visit;Vulnerable Populations;young adult;Youth

PROJECT_TITLE: Early Intervention for Youth At-Risk for Bipolar Disorder


ADMINISTERING_IC: AR

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Clinical Research;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Using mouse skin as model, this research takes molecular and genetic approaches to decipher how stem cells, as the natural units of tissue repair and homeostasis, are able respond to respond to local tissue and injury signals, replenish worn cells and repair wounds. Specifically, we aim to uncover how epidermal and hair follicle stem cells perceive external signals, remodel their chromatin and enter a plasticity state during wound repair, and how this differs in inflammation and malignancy. These findings will contribute to regenerative medicine and advance research for new diagnostics and therapeutics in treating inflammatory disorders and cancer.

PI_NAMEs: FUCHS, ELAINE  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Acute;Address;Adopted;Adult;adult stem cell;Affect;alpha ketoglutarate;Basal cell carcinoma;Behavior;beta catenin;Binding;Biological Assay;Cells;Chromatin;chromatin remodeling;Cleavage Under Targets and Release Using Nuclease;Collaborations;Development;Diet;Differentiation and Growth;Dioxygenases;Disease;DNA;DNA Methylation;Embryo;embryonic stem cell;Endowment;Enhancers;Environment;Enzymes;epidermal stem cell;Epidermis;epigenetic memory;Epigenetic Process;epithelial stem cell;Epithelium;Equilibrium;Event;experience;fitness;Flare;Gene Expression;Genes;genetic approach;Genetic Transcription;Genus Mentha;Goals;Growth;Guide RNA;Hair;Hair follicle structure;hair regeneration;Heart;high throughput technology;histone modification;Histones;Homeostasis;improved;in utero;in vivo;Inflammation;Inflammatory;Injury;insight;Instruction;Interphase Cell;Knowledge;Learning;Link;Malignant Neoplasms;Maps;Mediating;Memory;memory retention;Metabolism;Methods;Modeling;Molecular;Mus;Natural regeneration;new therapeutic target;novel diagnostics;novel therapeutics;Physiological;Pliability;prevent;Process;progenitor;programs;Property;Proteins;re-epithelialization;Recurrence;regenerative;Regenerative Medicine;Regulation;repaired;Reporter Genes;Repression;Research;Research Personnel;Signal Pathway;Signal Transduction;Skin;Skin repair;stem cell migration;stem cells;Stimulus;Succinates;TCF3 gene;Testing;Therapeutic;Therapeutic immunosuppression;therapy development;tissue regeneration;tissue repair;Tissues;transcription factor;transcriptomics;tumorigenic;WNT Signaling Pathway;wound;wound bed;wound healing;wound treatment

PROJECT_TITLE: Regulation of Epidermal Development and Differentiation-Renewal

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE This proposal seeks to continue for another five years the MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE or the “mSTUDY”) established in 2013 following across the HIV Prevention and Care Cascades a cohort of 514 younger mostly substance-abusing men of color who have sex with men (MoCSM) who are HIV+ and high risk HIV-. In this key population the mSTUDY cohort and its UCLA- based bio-behavioral repository creates a matchless platform to investigate basic, biological, and behavioral effects of active substance use, especially stimulant use (i.e., methamphetamine, amphetamine, cocaine, crack, ecstasy, and nicotine), cannabis, and opiates in MoCSM. We propose to address NIDA's 2016-2020 Strategic Plan priority focus areas and cross-cutting themes by rigorous assessments of the complex factors influencing substance use trajectories, health disparities, and biological effects of substances on immune function and HIV infection in very high-risk HIV– and HIV+ MoCSM contributing biobehavioral high impact science to address the public health challenge of curtailing HIV infections and comorbidities among substance-using MoCSM.

PI_NAMEs: GORBACH, PAMINA MAE (contact);SHOPTAW, STEVEN J

PROGRAM_OFFICER_NAME: DUNSTON, SHEBA KING

PROJECT_TERMS: Address;Adherence;Affect;Age;AIDS prevention;Amphetamines;Area;Basic Science;Behavior;Behavioral;biobank;biobehavior;Biological;Biological Markers;Biology;Black race;Blood;California;Cannabis;Caring;Cell Survival;Chlamydia;Cocaine;cohort;Cohort Studies;Collaborations;Communicable Diseases;Communities;comorbidity;Complex;Data;data integration;data repository;Disease;Disease Progression;disease transmission;Drug usage;ecstasy;Enrollment;Environment;Epidemiology;Face;Food;Fostering;Funding;Future;Gonorrhea;Health Benefit;health disparity;Healthcare;High Prevalence;high risk;HIV;HIV disparities;HIV Infections;HIV Seropositivity;HIV-1;HIV/AIDS;Housing;Immune;immune function;Immune response;Immunology;improved;Incidence;Infection;Inflammatory;Inflammatory Response;innovation;large datasets;Latino;Lead;Link;Liquid substance;Los Angeles;marginalization;Measurement;member;men;men of color;men who have sex with men;Mental disorders;Metabolic Diseases;metabolome;Methamphetamine;microbiome;Morbidity - disease rate;Mucous Membrane;Nail plate;National Institute of Drug Abuse;Nicotine;non-drug;novel;Opioid;Outcome;outreach;Participant;Pathogenesis;Patient Self-Report;Pattern;peripheral blood;Pharmaceutical Preparations;Pharmacotherapy;Population;Predisposition;Prevalence;Prevention;Prevention approach;Proteomics;Public Health;public health relevance;Publications;Regimen;repository;Research;Research Personnel;Research Project Grants;Respiratory Disease;response;retired men;Risk;Sample Size;Science;Scientist;sex;Sexually Transmitted Diseases;social;Social Behavior;Specimen;Stimulant;stimulant use;Strategic Planning;substance use;substance user;Syphilis;transmission process;United States;Universities;uptake;Visit;Work

PROJECT_TITLE: MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE)


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Immunization;Immunotherapy;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Worldwide infections with the bacterium Neisseria gonorrhoeae are a major problem, and increasing antibiotic resistance in this organism necessitates developing new approaches for prevention and treatment. The major manifestations of gonococcal infection worldwide are genital tract infections and conjunctivitis in the eye, the latter a major problem in infants born in low and middle income countries, manifest as ophthalmia neonatorum. This project will develop a mouse model to study N. gonorrhoeae conjunctivitis in adult and neonatal mice to evaluate vaccine candidates and mechanisms whereby they induce antibodies that can protect against infec- tion in the eye.

PI_NAMEs: PIER, GERALD B (contact)

PROGRAM_OFFICER_NAME: CONNOLLY, KRISTIE LEE

PROJECT_TERMS: acquired immunity;Active Immunization;Active Immunotherapy;Address;Adult;Antibacterial Response;Antibiotic Resistance;Antibiotics;Antibodies;Antibody-mediated protection;Antigens;antimicrobial;Antimicrobial Resistance;Bacteria;bactericide;Biological Assay;Blindness;Cattle;Cells;Cicatrix;clinically relevant;Coculture Techniques;Collaborations;Communicable Diseases;Communities;complement 4b-binding protein;Complement Factor H;Conjunctivitis;Cornea;corneal epithelium;Country;Development;Diagnosis;Disease;Dose;Edema;effective therapy;Epithelial Cells;Epithelium;Estradiol;Exclusion;experience;Eye;Eye Infections;Female;genital microbiota;Germ-Free;Goals;Gonorrhea;Growth;healthcare community;Human;Human Activities;human monoclonal antibodies;human pathogen;Immune;Immune response;Immunity;immunogenic;Immunology;Immunotherapeutic agent;Immunotherapy;In Vitro;in vitro Model;in vivo;Income;Infant;Infection;Inflammatory;Laboratory Animal Models;Letters;Licensing;lipooligosaccharide;Literature;low and middle-income countries;Lymphocytic Infiltrate;Measures;Mediating;Membrane Proteins;microbial;Microbiology;Modeling;Monoclonal Antibodies;mouse model;Mus;Natural Immunity;Needs Assessment;Neisseria gonorrhoeae;Neonatal;Neonatal meningitis;neonatal mice;novel;novel strategies;ocular surface;Ophthalmia Neonatorum;Organism;passive antibodies;Passive Immunization;Passive Immunotherapy;pathogen;Pathogenesis;Pathology;Physiology;poly-N-acetyl glucosamine;Polysaccharides;preservation;Prevention approach;prophylactic;protective efficacy;Publishing;PubMed;reproductive tract;Research Project Grants;Resistance;response;Serology;Serum;Site;Specificity;Standardization;Study models;success;Surface;System;Testing;Therapeutic;Therapeutic antibodies;tool;Transgenic Animals;transmission process;Treatment Efficacy;Uterus;Vaccine Antigen;vaccine candidate;vaccine evaluation;vaccine trial;vaccine-induced antibodies;Vaccines;Validation;Virulence;Virulence Factors;Visual;women's treatment;Work

PROJECT_TITLE: Development of a model of Gonococcal conjunctivitis for vaccine evaluations

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE MicroRNAs have been used as biomarkers for the diagnosis of many different diseases. Our recent discovery suggests that microRNAs become tiny RNAs upon viral infection, suggesting that tiny RNAs will serve as new potential biomarkers. This study will obtain the comprehensive profile of tiny RNAs during viral infection and reactivation, providing a solid foundation for diagnosing viral infection-driven neurological diseases.

PI_NAMEs: NAKANISHI, KOTARO  (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Affinity;anti-IgG;Antibodies;Biological Assay;Biological Markers;Body Fluids;Brain;Brain Injuries;Burkitt Lymphoma;Cell Line;Cells;Central Nervous System;Central Nervous System Diseases;Child;Data Set;Development;Diagnosis;Disease;Epstein-Barr Virus Infections;Foundations;frontier;Functional disorder;gammaherpesvirus;Gel;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Gene Silencing;Generations;Genes;Goals;Herpesviridae Infections;Hour;Human;Human Herpesvirus 4;Immunocompromised Host;Immunoprecipitation;Individual;Infection;Interferons;Label;Literature;Luciferases;Lymphocyte;Lymphoma cell;Lytic;Messenger RNA;microRNA biomarkers;MicroRNAs;Monitor;mRNA Translation;mutant;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;Neurologic;Neurons;Nucleotides;Outcome;Paper;Pathogenesis;Patients;Pattern;Phosphodiesterase I;Plasma;Point Mutation;potential biomarker;Proteins;Publishing;PubMed;Radiolabeled;reactivation from latency;Reporter;Reporting;RNA;RNA Interference;RNA-Induced Silencing Complex;Sepharose;Serum;Solid;Structure;System;Three Prime Repair Exonuclease 1;transcriptome sequencing;Transfection;Translational Repression;vector;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Tiny RNAs as new potential biomarkers for gammaherpesvirus-driven neurological and central nervous system diseases

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Aging;Neurosciences;Osteoporosis

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative The nervous system has been implicated in age-related bone loss, but the underlying mechanisms through which it directly promotes bone resorption are understudied. The proposed work will test the outstanding mechanistic questions of how the nervous system directly influences bone, which could lead to new treatments for osteoporosis.

PI_NAMEs: MOTYL, KATHERINE JEAN (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Adrenergic Antagonists;Adrenergic beta-Agonists;Adrenergic beta-Antagonists;Age;Age-Related Bone Loss;Aging;aging related;Agonist;Albuterol;Alleles;Attenuated;beta-adrenergic receptor;Binding;Biological Assay;bone;Bone Density;Bone Diseases;bone loss;Bone Marrow;Bone remodeling;Bone Resorption;Ca(2+)-Calmodulin Dependent Protein Kinase;Calcineurin;Calcineurin inhibitor;Cells;Clinical;Cohort Studies;Cyclic AMP-Dependent Protein Kinases;Data;Dose;Ensure;fracture risk;G Protein-Coupled Receptor Signaling;Genes;Genetic;Goals;Hand;Human;improved;In Vitro;in vivo;in vivo evaluation;Laboratories;Ligand Binding;Ligands;Marrow;Mass Spectrum Analysis;Mediating;Mediator;Meta-Analysis;monocyte;Mus;Myelogenous;Nervous System;novel;Nuclear;nuclear factors of activated T-cells;Osteoblasts;osteoclastogenesis;Osteoclasts;Osteogenesis;Osteoporosis;Pathology;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Postmenopause;PPP3CA gene;preclinical study;prevent;Propranolol;prospective;receptor;Receptor Signaling;recruit;Refractory;Role;Serum;Signal Pathway;Signal Transduction;Sympathetic Nervous System;Testing;transcriptome sequencing;Woman;Work

PROJECT_TITLE: A novel cell-autonomous role for β-adrenergic receptor signaling in osteoclasts

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN ANTONIO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: Aging is a major risk factor for the development of Alzheimer's disease (AD), but the underlying connection remains elusive. The proposed studies will determine the role of the ALCAT1 enzyme in linking aging with the development AD with an overarching goal of validating the enzyme as a novel drug target for the treatment of AD.

PI_NAMEs: SHI, YUGUANG  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Ablation;Acyl Coenzyme A;Acyltransferase;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Amyloid beta-Protein;APP-PS1;Attenuated;Bioenergetics;Brain;Cardiolipins;Cells;Cognitive deficits;cognitive function;Data;Defect;Development;Docosahexaenoic Acids;effective therapy;Enzymes;extend lifespan;Functional disorder;Generations;Genes;Goals;Heart failure;Impairment;Inflammasome;inhibitor;Knock-in Mouse;Link;lipidomics;Mediating;Mediator;Membrane;Metabolic;Metabolic Diseases;Metabolic Pathway;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;new therapeutic target;novel;oxidative damage;Oxidative Phosphorylation;Oxidative Stress;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Pathway interactions;peroxidation;pharmacologic;Phospholipids;Plague;Polyunsaturated Fatty Acids;prevent;pro-aging;Production;protein aggregation;Reactive Oxygen Species;response;Risk Factors;Role;Senile Plaques;Signal Pathway;targeted treatment;tau Proteins;Tauopathies;Testing;Up-Regulation;Work

PROJECT_TITLE: Cardiolipin Remodeling in Alzheimer’s Disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROSCIENCES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) is the most common source of late-life dementia, as well as the third leading cause of death in the United States, and currently has no effective treatment. Leveraging the most advanced BRAIN Initiative neurotechnologies in circuit tracing, sparse neuronal labeling, single-cell molecular profiling, and informatics, we will identify cell-type-specific connectional and molecular disruptions across age and in two AD mouse models, and will develop an integrated informatics pipeline and web-based visualization portal for data sharing. Together, our study will provide a rich resource to study selective molecular, cellular, and circuitry vulnerabilities in AD, and to provide novel readouts in two next-generation AD mouse models to study disease mechanisms and to test candidate therapeutics.

PI_NAMEs: DONG, HONG-WEI  (contact);LAMB, BRUCE T;YANG, XIANGDONG WILLIAM

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid;Amyloid beta-Protein;amyloid pathology;analysis pipeline;Anatomy;Atlases;Axon;Biological Assay;BRAIN initiative;Cause of Death;cell cortex;Cell Nucleus;cell type;Cells;Chromatin;cloud based;Collection;Computer software;connectome;connectome data;Consensus;Data;Data Analyses;data portal;data visualization;Dementia;digital;disease mechanisms study;effective therapy;entorhinal cortex;epigenomics;Female;Genetic;Genetic Models;genome-wide;hippocampal pyramidal neuron;In Situ Hybridization;in vivo;Informatics;Knock-in;Knock-in Mouse;Label;late life;Late Onset Alzheimer Disease;male;Maps;methylomics;Modeling;Molecular;molecular phenotype;Molecular Profiling;Morphology;mouse genetics;mouse model;multidisciplinary;multimodality;multiple omics;Mus;mutant;Neuroglia;Neurons;neurotechnology;new technology;next generation;normal aging;novel;Online Systems;Output;Pathologic;Pathology;Pathway Analysis;Process;Production;reconstruction;Resolution;Resources;response;scale up;sex;shape analysis;single nucleus RNA-sequencing;Source;Synapses;System;tau Proteins;Techniques;Testing;therapeutic candidate;transcriptomics;United States;Viral;Visualization

PROJECT_TITLE: Mapping Cellular Resolution Connectopathies in Aging and Alzheimer's Disease


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: STONY BROOK

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: PROJECT NARRATIVE World Trade Center (WTC) responders show elevated rates of mild cognitive impairment (MCI), an early sign of AD or a related dementia (ADRD). This study will examine small non-coding RNAs in monocyte subpopulation of Stony Brook WTC Health Program responders within a longitudinal study design, and integrate them with monocyte transcriptomic data to identify molecular mechanisms underlying monocyte dynamics and the biological processes involved in the progression of MCI to dementia. This knowledge will help researchers identify novel blood-based biomarkers for early detection of Alzheimer’s disease, and inform development of novel treatments.

PI_NAMEs: KUAN, PEI-FEN  (contact)

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Abeta clearance;Affect;Age;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease related dementia;Amyloid beta-42;Amyloid beta-Protein;Animal Model;Apoptosis;biobank;Biological;Biological Markers;Biological Process;Blood - brain barrier anatomy;blood-based biomarker;Cause of Death;Cells;cerebral atrophy;Cerebrum;Clinical Data;clinical phenotype;Cognition;cognitive function;cohort;Communication;Correlation Studies;cost effective;Data;deep sequencing;Dementia;Development;Disease;Disease Progression;DNA;early detection biomarkers;Epidemiology;Epigenetic Process;epigenetic regulation;Etiology;experience;Feasibility Studies;follow-up;frontal lobe;Functional disorder;gene environment interaction;Gene Expression;Gene Proteins;Gene Targeting;General Population;Genetic Transcription;genome-wide;Health;Human;Immune response;Immune system;immunoreaction;Impaired cognition;Impairment;Individual;Inflammation;insight;Knowledge;Longitudinal Studies;Machine Learning;Mediating;Metabolism;MicroRNAs;mild cognitive impairment;Modification;Molecular;Molecular Profiling;Molecular Target;monocyte;multiple omics;Nerve Degeneration;neuroinflammation;neuronal growth;neuropathology;Neuropathy;neurotoxic;normal aging;novel;Parietal Lobe;Pathogenesis;Pathologic Processes;Pathway interactions;Peripheral;Plasma Proteins;Play;potential biomarker;Process;programs;protein biomarkers;Recovery;Regulation;Reporting;Research;Research Design;Research Personnel;response;RNA;Role;Sampling;single-cell RNA sequencing;Survivors;symptom treatment;Symptoms;Synaptic plasticity;synergism;System;Tauopathies;Temporal Lobe;Terrorism;Time;transcriptome;transcriptomics;Trauma;United States;Untranslated RNA;Work

PROJECT_TITLE: Changes in monocyte small noncoding RNAs as a predictor of cognitive decline in mild cognitive impairment and Alzheimer's disease


NIH_SPENDING_CATS: Diabetes

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Failure of the islets of Langerhans leads to diabetes as a result of insufficient insulin release.  Cells within the islet are highly variable and show extensive crosstalk, yet how this variability  affects the way the islet releases insulin is poorly understood. A precise understanding of  these factors, including within human islets, will provide information as to how the  islet can become dysfunctional in diabetes, thus identify drug targets for preventative  treatments.

PI_NAMEs: BENNINGER, RICHARD KP (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Ablation;Activities of Daily Living;Acute;Address;Affect;Beta Cell;Blood Glucose;blood glucose regulation;Cells;Cessation of life;Characteristics;Communication;Computer Models;Coupling;Cyclic AMP;design;Diabetes Mellitus;diabetogenic;Drug Targeting;Endocrine;Environment;Experimental Models;experimental study;Failure;Functional dependence;Functional disorder;Funding;Gap Junctions;Glucagon;Glucose;Goals;Heterogeneity;Human;Image;Imaging Device;Immunofluorescence Immunologic;In Situ;Insulin;insulin regulation;insulin secretion;islet;Islets of Langerhans;Knowledge;Lasers;Mediating;Metabolic;Modeling;mouse model;Mus;Pancreas;pancreatic islet function;Pathogenicity;Permeability;pharmacologic;Phase;Phenotype;Population;Population Heterogeneity;Preparation;Preventive treatment;programs;Property;recruit;Regulation;Reporter;Research;response;Role;Slice;small molecule;System;Testing;therapeutic target;tool

PROJECT_TITLE: Emergent Multi-Cellular Properties Regulating Pancreatic Islet Function

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]