NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_NAME: ALBERT EINSTEIN HEALTHCARE NETWORK

PHR: More than 750,000 individuals in the U.S. have a stroke each year, and as many as 94% of stroke survivors exhibit reduced use of one arm, with adverse consequences for disability, caregiver burden, and quality of life. Approximately 40%-80% of individuals who fail to use the affected arm in daily life possess adequate sensorimotor capacity to do so. The disparity between actual arm use and capacity remains a perplexing and urgent problem in neuro-rehabilitation. The proposed research will determine the underlying behavioral and neuroanatomic substrates of arm use/capacity disparity (UCD) and will validate a novel virtual reality assessment tool for detection of UCD. The investigations are designed to serve as a well-planned stage in the translational pipeline and will thus provide a critical bridge to developing a large-scale randomized control trial in at-risk individuals using a targeted treatment.

PI_NAMEs: BUXBAUM, LAUREL J (contact);KANTAK, SHAILESH

PROGRAM_OFFICER_NAME: NITKIN, RALPH M

PROJECT_TERMS: 3-Dimensional;Adopted;adverse outcome;Affect;Affective;Age;Area;arm;Assessment tool;Attention;base;Behavioral;Behavioral Mechanisms;Biological Markers;Brain;Caregiver Burden;chronic stroke;Classification;Clinical;Clinical Treatment;Cognitive;Data;Data Analyses;design;Detection;disability;Disease;Disparity;Exhibits;experience;Functional Magnetic Resonance Imaging;Grant;Home;imaging biomarker;improved;Individual;Investigation;Knowledge;knowledge base;Left;Life;Limb structure;Linear Models;Measures;Methods;Modeling;Modification;Monitor;Motivation;Motor;Movement;Neuroanatomy;neuroimaging;neurological rehabilitation;Neuropsychological Tests;Neuropsychology;Neurosciences;novel;Paresis;Predictive Factor;Prevalence;Property;psychologic;Psychometrics;Quality of life;Randomized, Controlled Trials;Reality Testing;Research;research clinical testing;Research Personnel;Rest;Rewards;Risk;Running;Sampling;Sensory;Severities;Stroke;stroke patient;stroke survivor;Syndrome;targeted treatment;Testing;therapy development;Training;translational pipeline;Upper Extremity;virtual reality;Work

PROJECT_TITLE: Mechanistic and neuroanatomic bases of disparity between arm capacity and use in stroke

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_CITY: Aurora

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANESTHESIOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative  This proposed research will study how inhibition of voltage-gated calcium currents in thalamocortical and hippocampal circuitry contributes to the spectrum of clinical effects exerted by different categories of general anesthetics. The findings may be important for understanding cellular mechanisms of anesthesia such as loss of consciousness and amnesia, as well as potential development of novel, safer anesthetics.

PI_NAMEs: TODOROVIC, SLOBODAN M. (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Acute Pain;Address;Amnesia;Anesthesia procedures;Anesthetics;Area;behavior test;Brain region;Calcium;Calcium Channel;Calcium Channel Inhibition;Categories;chronic pain;Clinical;clinical effect;clinically relevant;Collaborations;Collection;Development;Drug Targeting;Electrophysiology (science);Event;Face;Family;flexibility;General anesthetic drugs;Goals;Hippocampal Formation;Hippocampus;Hypnosis;Immobilization;in vivo;innovation;interest;Ion Channel Gating;knock-down;Learning;Ligands;Medical;Membrane;Memory;Memory impairment;Molecular;mouse genetics;Movement;National Institute of General Medical Sciences;Neurons;neurophysiology;novel;Optics;pain processing;pain sensation;Pathway interactions;Pharmacology;Postoperative Pain;Productivity;Protein Isoforms;Proteins;Regulation;Research;Role;Sleep;Synaptic Transmission;T-Type Calcium Channels;Thalamic structure;Unconscious State;voltage;Work

PROJECT_TITLE: Voltage-gated calcium channels as target for anesthetics

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative The GABAA receptor is the major target for intravenous anesthetics. The project will investigate how various endogenous and clinical compounds, through effects on the GABAA receptor, initiate the onset and offset of anesthesia.

PI_NAMEs: AKK, GUSTAV  (contact)

PROJECT_TERMS: Action Potentials;Affect;Agonist;Anesthesia procedures;Anesthetics;Brain;Cells;Clinical;clinically relevant;feasibility testing;Fire - disasters;gamma-Aminobutyric Acid;Individual;Intravenous Anesthetics;Ion Channel;Kinetics;Mediating;neurosteroids;Physiological;Physiology;receptor;Recovery;response;sedative;Steroids;Synapses;Testing

PROJECT_TITLE: GABAA receptors: function, physiology and involvement in anesthesia


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: ADVANCED SCIENCE RESEARCH CENTER

ORG_STATE: NY

PHR: Project Narrative This proposal addresses the mechanisms underlying the early events of Alzheimer’s disease and related dementias by using oligodendrocyte biology-inspired and rigorous biophysical approaches to the study of tau condensates.

PI_NAMEs: ELBAUM, SHANA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Address;Alzheimer's Disease;Alzheimer's disease related dementia;Animal Model;Architecture;Behavior;Biochemistry;Biology;biophysical techniques;Biophysics;Cell Lineage;Cell Physiology;Cells;Central Nervous System;Complement;Confusion;Detection;Disease;effective therapy;Environment;Etiology;Event;Fiber;Foundations;Frontotemporal Dementia;Functional disorder;Future;Gel;Goals;human subject;Image;Impaired cognition;Impairment;interdisciplinary approach;Knowledge;Lipids;Measures;Mediating;mild cognitive impairment;Modeling;Molecular;Monitor;Mutation;Myelin;Myelin Basic Proteins;myelin biogenesis;Myelin Proteins;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel;novel therapeutic intervention;oligodendrocyte lineage;Oligodendroglia;Oxidative Stress;Pathogenicity;Pathologic;Pathology;Pathway interactions;Phase;Physical condensation;Post-Translational Protein Processing;Process;Property;protein aggregation;Protein Isoforms;Proteins;Reporting;Research Priority;Resolution;Role;self assembly;Site;symposium;tau mutation;tau Proteins;Testing;therapeutic target;tool;United States National Institutes of Health;Variant;white matter change;Work

PROJECT_TITLE: Architecture, dynamics and cell-specific behavior of tau condensates

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Narrative There is an unmet medical need to develop new and improved analgesics to treat chronic pain. The goal of this proposal is to understand how small extracellular vesicles secreted by monocytes/macrophage can regulate immune cells and influence “memory” in microglia to attenuate pain to a future painful insult. The studies proposed can help us understand the mechanisms of pain prophylaxis and thereby mitigate pathological pain without impacting physiological pain that serves important protective functions.

PI_NAMEs: AJIT, SEENA  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acetylation;adaptive immune response;Adjuvant;Adjuvant Therapy;Affect;Age;Analgesics;Anti-Inflammatory Agents;Architecture;Attenuated;attenuation;Cells;Cellular Morphology;Central Nervous System;chromatin immunoprecipitation;chronic pain;chronic pain management;Circulation;Communication;cytokine;Cytometry;Deposition;Disabling;Dose;Enhancers;Epigenetic Process;extracellular vesicles;Future;Gene Expression;Goals;Grant;histone methylation;histone methyltransferase;Histones;Hypersensitivity;Immune;Immune response;Immunologic Markers;Immunologic Memory;Immunologics;Immunophenotyping;immunoregulation;improved;In Situ;In Vitro;in vivo;Induction of Apoptosis;inflammatory marker;inflammatory pain;inhibitor;Injections;Innate Immune Response;intercellular communication;Interleukin-10;Interleukin-6;Intrathecal Injections;lipid mediator;Lipids;long term memory;Macrophage;Mediating;Medical;member;Memory;Messenger RNA;Microglia;MicroRNAs;Modeling;Modification;monocyte;mouse model;Mus;novel;Pain;pain relief;Pathologic;Phenotype;Physiological;Play;Preparation;Process;prophylactic;Prophylactic treatment;Proteins;Public Health;recruit;Resolution;response;RNA Transport;Role;Serum;sex;Signal Transduction;small molecule;Source;Spinal;Spinal Cord;Spinal cord posterior horn;Spinal Ganglia;System;Technology;Testing;Therapeutic;Tissue Sample;Tissues;TNF gene;Transforming Growth Factor beta;United States;Up-Regulation;uptake;vaccination strategy;vesicle transport;vesicular release

PROJECT_TITLE: Small extracellular vesicles mediated signaling and pain


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Cancer;Cancer Genomics;Coronaviruses;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_DEPT: CHEMISTRY

ORG_NAME: NEW YORK UNIVERSITY

PHR: Relevance  Using new multiscale biomolecular modeling and simulation methods that can yield mechanistic insights, Schlick's multidisciplinary team will address fundamental challenges in biology in relation to human disease: genome reorganization in cancer processes and RNA co-transcriptional folding in viral mechanisms. A linking of the many relevant biological scales and heterogeneous features of each is essential for understanding the complex biological activities of these macromolecules in the cellular environment and how they aﬀect gene expression, cancer progression, and viral infection. Such an improved understanding of the organization and transition mechanisms associated with the genetic material and its RNA cousin, together with establishment of systematic methods for their study, has direct medical ramiﬁcations by suggesting speciﬁc molecular design and targeted therapies for the treatment of genetic syndromes, degenerative diseases, cancers associated with chromosomal or epigenetic abnormalities, and viral infections like Covid-19.

PI_NAMEs: SCHLICK, TAMAR  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: 2019-nCoV;Affect;Anti-viral Therapy;Atlases;Biological;Biology;biophysical analysis;biophysical model;Biophysical Process;Biophysics;cancer cell;cancer genomics;cancer therapy;Chemicals;Chemistry;Chromatin;Chromatin Fiber;Chromosomes;Collaborations;Communities;Complex;Computational Biology;computer science;Coronavirus;Coronavirus Infections;COVID-19;Data;Degenerative Disorder;design;Diagnosis;Disparate;Elements;Engineering;Environment;Epigenetic Process;epigenomics;experimental study;Gene Activation;Gene Expression;gene repression;Gene Silencing;Genes;Genetic;Genetic Materials;Genetic Transcription;Genome;genome-wide;Grain;Graph;Higher Order Chromatin Structure;HIV;Human;human disease;improved;innovation;insight;Lead;Link;macromolecule;Malignant Neoplasms;Mathematics;Medical;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;multi-scale modeling;multidisciplinary;Mutation;novel;Nuclear;Nucleic Acids;Nucleosomes;Play;Process;protein complex;Proteins;Research;Resolution;Ribosomal Frameshifting;RNA;RNA Conformation;RNA Editing;RNA Virus Infections;Role;simulation;Structure;Syndrome;targeted treatment;Technology;Testing;tumor progression;Viral;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: Bridging Disparate Structural/Functional Scales: Multiscale Modeling of Genome Organization and of Viral RNA Frameshifting

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE This proposal develops novel methods based on combining long-read sequencing technologies to characterize the sequence structure, variation, and annotation of protein-coding genes within complex regions of duplication that have been difficult to sequence and assemble. The work will improve the quality of the reference genome, provide a fundamental understanding of how new genes arise, and improve genotyping of copy-number genes and the importance of duplication to human disease and adaptation.

PI_NAMEs: EICHLER, EVAN  (contact)

PROGRAM_OFFICER_NAME: ARGUELLO, ALEXANDER

PROJECT_TERMS: Accounting;Biological Assay;Callithrix;Code;Collaborations;Complementary DNA;Complex;Consensus Sequence;Copy Number Polymorphism;cost;Coupled;Coupling;Data;Data Set;Diploidy;Disease;DNA;Epigenetic Process;Event;Evolution;Exclusion;frontal lobe;Gene Conversion;Gene Dosage;Gene Duplication;Generations;Genes;genetic evolution;Genetic Transcription;Genetic Variation;Genome;genome-wide;Genomic Segment;Genomics;Genotype;Genotype-Tissue Expression Project;Genus Mentha;Goals;Gorilla gorilla;Graph;Haploidy;Haplotypes;Human;human disease;Human Genetics;Human Genome;human pangenome;human reference genome;Hybrids;improved;insight;Length;Linkage Disequilibrium;Macaca;Methods;Methylation;Modeling;Mutation;nanopore;nonhuman primate;novel;Nucleotides;Pan Genus;Pattern;Peptide Signal Sequences;Phase;Phylogenetic Analysis;Pongidae;Pongo pygmaeus;Population;population stratification;Process;programs;Protein Isoforms;Proteins;Protocols documentation;Recurrence;reference genome;Research;Resources;RNA;Sampling;scaffold;Shapes;Signal Transduction;Single Nucleotide Polymorphism;Source;Structure;Technology;telomere;Time;transcriptome sequencing;Variant;whole genome;Work

PROJECT_TITLE: Long-read sequence and assembly of segmental duplications

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_CITY: HANOVER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: NARRATIVE Reversible protein phosphorylation established by a ‘tug of war’ between kinases and phosphatases controls most cellular processes and is often deregulated in human diseases. The long-term goal of our research program is to uncover the mechanisms that coordinate and integrate phosphatases and kinases and their shared substrates in signaling networks. This knowledge will help us understand how disruption of the phosphorylation balance contributes to disease and identify new drug targets and points of therapeutic intervention.

PI_NAMEs: KETTENBACH, ARMINJA NADINE (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Biochemical;Biological;Catalytic Domain;Cell division;Cell Physiology;Cells;combinatorial;Communities;Databases;Disease;Ensure;Enzymes;Equilibrium;Family;Foundations;Goals;Holoenzymes;human disease;In Vitro;inhibitor;Knowledge;Maps;Measurement;Mediating;Mitosis;new therapeutic target;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphorylation Site;Phosphotransferases;programs;Protein Dephosphorylation;Protein phosphatase;Proteins;Proteome;reconstitution;recruit;Regulation;Research;Role;Signal Transduction;Site;Specificity;Substrate Specificity;Therapeutic Intervention;user-friendly

PROJECT_TITLE: Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Dissemination and Implementation Research;Machine Learning and Artificial Intelligence;Nutrition;Obesity;Prevention

ORG_CITY: KINGSTON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: Title: Development of personalized healthy food incentives to improve diet and cardiovascular risk PROJECT NARRATIVE Diet has emerged as the leading risk factor for cardiovascular diseases responsible for substantial morbidity and mortality among US adults. Despite the enormous human toll and fiscal burden of diet-related chronic disease, population interventions have insufficiently addressed the complex determinants of this behavioral risk factor. The proposed research strives to improve public health by applying advancements in machine learning and qualitative research to better understand drivers of dietary decisions and using that insight to refine and test an automated personalized healthy food incentive platform to improve healthy food purchases, diet quality, and cardiovascular risk factors.

PI_NAMEs: VADIVELOO, MAYA  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;Address;Adopted;Adoption;Adult;Affect;arm;Award;Behavior;Behavior Therapy;Behavioral;behavioral economics;behavioral health;Big Data;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;career;Categories;Chronic Disease;clinically significant;cohort;Collaborations;Complex;Consumption;cost;Data;Data Science;Decision Theory;Decision Trees;design;Development;Diet;dietary;Dietary intake;Dietary Intervention;Dietary Practices;Dissemination and Implementation;Eating;Education;Effectiveness;Ensure;Environment;Focus Groups;Food;fruits and vegetables;Future;Goals;good diet;Gorilla gorilla;group intervention;Health;Health Food;health goals;Healthy Eating;high risk;Human;Hypertension;implementation framework;implementation research;improved;Incentives;insight;Intake;Interdisciplinary Study;Intervention;intervention participants;Intervention Trial;Knowledge;literacy;Logic;Machine Learning;Mentors;Mentorship;Methodology;Methods;Modeling;Morbidity - disease rate;mortality;novel;nutrition;Nutritional Study;Obesity;Participant;personalized intervention;personalized strategies;pilot test;Policies;Population;Population Intervention;Positioning Attribute;preference;programs;Public Health;Qualitative Research;Randomized;Randomized, Controlled Trials;Recipe;Recommendation;Research;Research Personnel;Rhode Island;Risk Factors;Sales;Strategic Planning;Surveys;Technology;Testing;Time;tool;Training;training opportunity;translational research program;Unhealthy Diet;United States National Institutes of Health;willingness

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Mental Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE  Building on the strong training track records of and successful collaborations between UNC-Chapel Hill, the Malawi College of Medicine, the Malawi Ministry of Health, and many other partners, we will accelerate mental health research capacity across the lifespan in Malawi by employing a model that emphasizes three complementary dimensions: depth (in-depth investment to create a core of skilled researchers and thought leaders), breadth (engagement of a wide range of stakeholders in mental health research), and reach (building links between research, policy, and practice to maximize impact of research). The Malawian Program for Mental Health Research Training (WARMHEART) will have a tremendous impact on mental health research in Malawi, creating an expert pool of young mental health researchers trained as leaders and able to collaborate with other disciplines and policymakers to address the role of psychiatric illness across the lifespan.

PI_NAMEs: GAYNES, BRADLEY N (contact);KULISEWA, KAZIONE

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;Area;Clinical;Collaborations;college;Communicable Diseases;Country;Development;Dimensions;disability-adjusted life years;Discipline;Educational workshop;experience;Faculty;Funding;Generations;Growth;Health;Heart;HIV;Journals;Leadership;life span;low and middle-income countries;Malawi;Medical;medical specialties;Medicine;meetings;Mental disorders;Mental Health;Mentors;Mentorship;Modeling;Policies;Policy Developments;Policy Maker;Postdoctoral Fellow;programs;Psychiatrist;Psychiatry;Records;Research;research and development;Research Personnel;Research Priority;Research Project Grants;research to practice;Research Training;Role;Series;skills;symposium;Training;Translating;Translations;Writing;years lived with disability


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Digestive Diseases;Infant Mortality;Liver Disease;Microbiome;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Premature babies born less than 3.3lbs are not able to gain weight after birth. Current nutritional strategies fail to meet the needs of premature babies leading to malnutrition, growth failure, and short- and long-term health deficits. This study will identify fundamental new associations between fat absorption, gut bacteria, and bile acids relative to neonatal morbidities and growth failure.

PI_NAMEs: HAIR, AMY BORISKIE (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: absorption;Address;Age;analytical tool;Animals;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;bile salts;Biological Availability;Birth;Blood;Brain;Characteristics;Cholestasis;Chronic lung disease;Clinical;Clinical Nutrition;cohort;Coupled;Development;Diet;Dietary Fatty Acid;Dietary intake;Digestion;donor milk;Early Intervention;effective intervention;Enteral;enzyme activity;Enzymes;experience;Failure;Fatty acid glycerol esters;Fatty Acids;Feces;Future;Gene Dosage;Genes;Growth;gut bacteria;gut microbiome;gut microbiota;Health;Health Benefit;high risk;Homeostasis;Hour;Human Milk;Hydrolase;immune function;Immunologic Factors;Impairment;improved;In Vitro;Individual;infancy;Infant;infant outcome;Inflammatory;Infrastructure;Intestinal Absorption;Intestines;Knowledge;Life;Linear Models;Link;Lipase;Lipids;Liver;long chain fatty acid;Malabsorption Syndromes;Malnutrition;Mass Fragmentography;Measures;Metabolic Pathway;metagenome;Microbe;microbial;Modeling;Morbidity - disease rate;mortality;Necrotizing Enterocolitis;Neonatal;neonatal care;neonatal morbidity;novel;novel therapeutics;Nutrient;nutrition;Nutritional;Outcome;pasteurization;Pathogenesis;Physiology;Placenta;placental transfer;Polyunsaturated Fatty Acids;Population;postnatal;premature;Premature Birth;Premature Infant;prospective;recruit;Regulation;Retina;Retinopathy of Prematurity;Risk;Sepsis;Serum;Shapes;Shotgun Sequencing;Technology;therapeutic target;Third Pregnancy Trimester;Time;uptake;Very Low Birth Weight Infant;Weight Gain

PROJECT_TITLE: Liver-Gut-Microbiome Axis and Fatty acid absorption in Preterm Infants

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases;Tuberculosis

ORG_CITY: MADISON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Tuberculosis is a significant, global health problem for humankind and recently, SARS-CoV-2 became another significant problem for public health authorities worldwide. Studying the interactions of both infections is of a paramount importance. Outcomes from this project will further improve our understanding of Tuberculosis (TB) immunopathogenesis and how latent infections in humans can convert to active cases of TB.

PI_NAMEs: TALAAT, ADEL M (contact)

PROGRAM_OFFICER_NAME: EICHELBERG, KATRIN

PROJECT_TERMS: 2019-nCoV;Address;Antitubercular Agents;authority;C3HeB/FeJ Mouse;Case Management;Cessation of life;Containment;COVID-19;COVID-19 pandemic;cytokine;Data;Death Rate;Emerging infection;Future;Genes;global health;Goals;Granuloma;Growth;Health;Histologic;Histopathology;Human;Immune response;Immunize;Immunocompetent;Immunologics;immunoregulation;improved;in vivo;Inbred Mouse;Inbreeding;Infection;Inflammation;Influenza;insight;Interferon Type II;Interleukin-10;Knowledge;latent infection;Lung;Modeling;mouse model;Mus;mycobacterial;Mycobacterium tuberculosis;Organ;Outcome;pandemic disease;pathogen;Pathogenesis;Pathogenicity;Pathologic;Patients;Phase;Population;Public Health;rBCG;Reporter;Reporting;respiratory;Role;SARS-CoV-2 B.1.1.529;Structure;superinfection;Testing;Time;Tissues;Transcript;Transgenic Mice;Tuberculosis;tuberculosis immunity;Variant;Viral

PROJECT_TITLE: Tuberculosis Immunopathogenesis During Superinfection with SARS-CoV2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: The goal of this proposal is to define brain mechanisms that favor recall of safety learning over memories of danger. The results will further our understanding of recovery from trauma and help establish treatments to prevent the return of pathological fear following behavioral therapy.

PI_NAMEs: CLEM, ROGER L (contact)

PROGRAM_OFFICER_NAME: VICENTIC, ALEKSANDRA

PROJECT_TITLE: Microcircuits governing conflicting memories of threat and safety

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: Newark

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative In this project, we propose to evaluate the immunogenicity and efficacy of a novel recombinant vaccine (rBCG) in combination with a host immune modulator (Everolimus) and front-line anti-TB drugs (INH+RIF) in shortening tuberculosis therapy and/or improve clinical outcome of treatment. We will use preclinical animal models of cavitary tuberculosis (rabbits) and latent infection (model) for the proposed studies.

PI_NAMEs: SUBBIAN, SELVAKUMAR  (contact)

PROGRAM_OFFICER_NAME: MAHON III, ROBERT N

PROJECT_TERMS: active control;adaptive immunity;Adult;Aerosols;Animal Model;Antibiotics;Antimycobacterial Agents;Attenuated;Attenuated Vaccines;BCG Live;Biological Models;Blood;booster vaccine;CD4 Positive T Lymphocytes;Cells;Child;Clinical;Clinical Trials;co-infection;combat;combinatorial;Communities;Containment;Development;Disease;drug candidate;Functional disorder;Generations;Health;HIV;Human;Immune;immune modulating agents;Immunity;Immunocompetent;Immunocompromised Host;immunogenic;immunogenicity;Immunomodulators;Immunosuppression;improved;improved outcome;Individual;Intervention;isoniazid;latent infection;Licensing;Lung;Measures;Memory;Modeling;Morbidity - disease rate;mortality;mouse model;mTOR Inhibitor;Mucous Membrane;Mus;Mycobacterium bovis;Mycobacterium tuberculosis;Mycobacterium tuberculosis antigens;Natural Immunity;novel;novel vaccines;Oryctolagus cuniculus;pathogen;pathogenic bacteria;Pathogenicity;Pathologic;Pathology;Pharmaceutical Preparations;Pharmacotherapy;Population;pre-clinical;Pre-Clinical Model;prevent;protective efficacy;Pulmonary Tuberculosis;reactivation from latency;Recombinant Vaccines;Recombinants;Recurrence;Recurrent disease;recurrent infection;Regimen;Reproducibility;response;Rifampin;Role;Safety;Science;SDZ RAD;Source;T cell response;Testing;Therapeutic;therapeutic vaccine;therapy duration;Training;transmission process;Treatment outcome;Tuberculosis;tuberculosis drugs;tuberculosis treatment;Tuberculosis Vaccines;Vaccination;vaccine candidate;vaccine evaluation;vaccine platform;Vaccines;Virulence;World Health Organization

PROJECT_TITLE: Optimizing vaccine science to improve the outcome of tuberculosis treatment


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Neurosciences;Pediatric;Urologic Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in the first three decades of life. However, therapeutic interventions remain limited, and many children progress to end-stage renal disease. Recent studies have revealed over 40 novel monogenic causes of human CAKUT, the majority of which coalesce into pathways that regulate nephrogenesis. Monogenic causes of lower urinary tract disease are largely unknown. The aim of this career development grant is to discover novel monogenic causes of bladder dysfunction and to explore the molecular mechanisms by which mutations in these genes cause human disease.

PI_NAMEs: MANN, NINA  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Adult;Advisory Committees;Affect;Anatomy;Animal Model;Autonomic nervous system;Behavior;Behavioral;Bladder;Bladder Dysfunction;Boston;Candidate Disease Gene;career development;Child;Childhood;Chronic Kidney Failure;cohort;congenital anomalies of the kidney;Copy Number Polymorphism;Data;Defect;Development;Development Plans;diagnostic value;Disease;End stage renal failure;Ensure;Environment;Etiology;exome;exome sequencing;Gene Expression;Genes;Genetic;genetic disorder diagnosis;genetic pedigree;genetic variant;Genets;Genitourinary system;Genomic approach;Genomics;Grant;healthcare burden;Human;human disease;Impairment;Individual;insight;International;Kidney;Laboratories;Life;Lower urinary tract;malformation;Mediating;medical schools;meetings;Mentors;Mesenchyme;Metanephric Diverticulum;Methods;Microarray Analysis;Molecular;Muscle Contraction;Muscle relaxation phase;Mutation;nephrogenesis;nerve supply;Nervous System Physiology;Neurogenic Bladder;Neurologic Deficit;Nicotinic Receptors;novel;novel therapeutic intervention;Obstruction;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pediatric Hospitals;Population;prenatal;prevent;Proteins;Regulation;Relaxation;Renal Replacement Therapy;Reporting;Research;research and development;Research Personnel;RNA Splicing;Signal Transduction;Smooth Muscle;Specimen;success;symposium;Syndrome;Techniques;Therapeutic;Therapeutic Intervention;Training;transcriptome sequencing;transcriptomics;urinary;Urinary tract;urinary tract obstruction;Urine;Urologic Diseases;Urothelium;Validation;Variant

PROJECT_TITLE: Discovery and pathogenic characterization of novel monogenic causes of bladder dysfunction.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Orphan Drug;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE The only approved molecular targeting agent in the treatment of head and neck cancer (HNC) is cetuximab, an antibody directed against the EGFR. The vast majority of patients are either intrinsically resistant or acquire resistance to this promising agent. We have identified the receptor tyrosine kinase AXL mediates resistance through the c-Abl kinase and together function as a major driver of resistance. We will investigate how AXL and c-Abl mediates resistance, whether c-Abl targeting can re-sensitize tumors to cetuximab in a clinical trial and if AXL and c-Abl association can serve as a biomarker to predict cetuximab resistance in HNC.

PI_NAMEs: SALGIA, RAVI ;WHEELER, DERIC L (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: ABL1 gene;Ablation;aggressive therapy;Antibodies;Apoptosis;Architecture;axl receptor tyrosine kinase;Biological Markers;Biological Models;Biology;Cancer cell line;Cancer Model;cancer therapy;Cell Line;Cell Nucleus;Cessation of life;Cetuximab;chemotherapy;Clinic;Clinical;Clinical Treatment;Clinical Trials;cohort;CRISPR/Cas technology;Cytoplasm;Cytosol;Data;Diagnosis;Distant Metastasis;Epidermal Growth Factor Receptor;Exhibits;Family;FDA approved;Future;Genetic;Goals;Head and Neck Cancer;head and neck cancer patient;HPV positive;HPV-negative head and neck cancer;Human;Imatinib;Immunotherapy;improved;improved outcome;In Vitro;in vivo;in vivo evaluation;in vivo Model;Investigation;kinase inhibitor;Lead;Life;Malignant Neoplasms;Maps;Measures;Mediating;Metastatic/Recurrent;Modeling;Molecular;Molecular Target;Monoclonal Antibodies;Mus;mutant;Mutate;Neoplasm Circulating Cells;novel;novel therapeutics;Nuclear;Nuclear Export;Operative Surgical Procedures;overexpression;Pathologic;Pathway Analysis;Pathway interactions;patient derived xenograft model;Patients;Persons;Pharmaceutical Preparations;Phosphotransferases;Platinum;Play;Pre-Clinical Model;predictive marker;prevent;Protein Tyrosine Kinase;Proteomics;Radiation;Radiation therapy;Recurrence;Refractory;Regimen;Relapse;Reproduction spores;Research;Resistance;Resistance development;response;Role;safety and feasibility;Sequence Deletion;Series;Signal Pathway;Signal Transduction;small molecule inhibitor;Specimen;targeted agent;Therapeutic;therapeutic evaluation;therapeutic target;therapy resistant;Tissues;Translating;Treatment outcome;tumor;Tyrosine;virtual;Wisconsin;Work;Xenograft procedure;Zebrafish

PROJECT_TITLE: Cooperation of the TAM and Abl family kinases in therapeutic resistance in HNC

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Lymphatic Research;Lymphedema;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Narrative Lymphedema is the leading cause of morbidity and mortality in the USA; however, clinical therapies aiming to grow lymphatic vessels in the body are currently lacking. Recently, we developed innovative technologies for directly reprogramming somatic cells toward lymphatic endothelial cells (rLECs), bypassing a stem cell stage. In this proposal, we will develop clinically compatible ETV2 vector and rLECs, and determine the therapeutic effects of direct delivery of ETV2 gene aor transplantion of rLECs on lymphedema animal models.

PI_NAMEs: LEE, SANG-HO ;YOON, YOUNG-SUP  (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adenovirus Vector;adult stem cell;Animal Model;Biological;Biological Response Modifier Therapy;Body Fluids;Bypass;Cardiovascular Diseases;Cardiovascular system;Cell Lineage;Cell Reprogramming;Cell Therapy;cell type;Cells;Characteristics;Clinical;clinical application;clinical translation;cost;Data;delivery vehicle;Dependence;Development;Disease;Embryo;Endothelial Cells;Exhibits;experimental study;Fibroblasts;Fluid Balance;Gene Modified;gene therapy;Generations;Genes;Genomics;Goals;Growth;Histologic;Human;human embryonic stem cell;human pluripotent stem cell;Imaging technology;Immunologic Surveillance;Impairment;in vivo;Incidence;induced pluripotent stem cell;innovative technologies;Insertion Mutation;insight;Lentivirus Vector;Lymphatic;lymphatic development;Lymphatic Endothelial Cells;Lymphatic function;lymphatic vessel;Lymphedema;Magnetic Resonance Imaging;Measurement;Methods;Molecular;Morbidity - disease rate;mortality;Mus;Natural regeneration;Near-infrared optical imaging;neovascularization;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Obstruction;overexpression;Palliative Surgery;paracrine;Play;programs;regenerative therapy;Regulation;Research;Residual state;Role;side effect;Somatic Cell;stem cells;success;Therapeutic;Therapeutic Effect;Tissues;transcription factor;Transplantation;Tumorigenicity;Undifferentiated;Variant;vector;Viral;wound healing

PROJECT_TITLE: Lymphatic Regeneration by Direct Cellular Reprogramming

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Neurosciences;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This project represents an important step towards understanding how nicotine and tobacco products (NTPs) and cannabis differentially influence emerging adult brain development when used together versus separately. Advanced multimodal neuroimaging techniques, cognitive assessment, and bioassays of circulating blood endocannabinoids will prospectively identify neural, cognitive, and stress and reward system alterations among young adults that play a role in the development of substance use disorders and psychopathology into adulthood. Elucidating the neurobiological consequences of emerging adult cannabis and NTP use will help inform the regulation of cannabis and NTP products and the development of novel neuroscience-informed prevention and intervention strategies.

PI_NAMEs: JACOBUS, JOANNA  (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: 19 year old;2-arachidonylglycerol;addiction;Adolescent;Adult;Age;alcohol use disorder;Animal Model;Anisotropy;Architecture;arterial spin labeling;Attention;Attitude;Axon;Behavior;Behavioral;behavioral outcome;Biological Assay;Blood;blood perfusion;Blood Vessels;Brain;brain health;Cannabis;Cannabis policy;Cerebrovascular Circulation;Characteristics;Chronic stress;Cognition;Cognitive;cognitive control;cognitive testing;Coupled;craving;density;Development;Disease;emerging adult;emotional distress;Endocannabinoids;endogenous cannabinoid system;Enrollment;Environment;Fiber;follow-up;Frequencies;frontal lobe;gray matter;Health;health assessment;Human;Hyperactivity;indexing;Individual;innovation;Intervention;intervention program;Interview;Laboratories;Learning;Magnetic Resonance Imaging;Magnetoencephalography;marijuana use;marijuana user;Measurement;Measures;Mediating;Mental Health;Metabolic;Methods;Modality;multimodal neuroimaging;Myelin;negative affect;negative emotional state;neural;neural correlate;Neurites;Neurobiology;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neurosciences;Nicotine;nicotine use;novel;Outcome;Participant;Pattern;peer;Perception;Perfusion;permissiveness;Persons;pre-clinical;Predisposition;Prevention program;Prevention strategy;prospective;Psychopathology;Public Health;Public Policy;receptor;recruit;Reporting;Research;Resolution;Rest;Restriction Spectrum Imaging;Rewards;Risk;Sampling;Schizophrenia;Serum;Severities;Signal Transduction;social;Stress;Structure;substance use;Substance Use Disorder;substance user;symptomatology;Symptoms;Synapses;System;Techniques;Tetrahydrocannabinol;Tissues;Tobacco;Tobacco Industry;tobacco products;Tobacco use;Traumatic Brain Injury;vaping nicotine;Visit;Vulnerable Populations;white matter;young adult;Youth

PROJECT_TITLE: Cannabis and Nicotine Co-Use Influences on Protracted Development of Neural Structure and Function

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: NARRATIVE We will ascertain and genotype large cohort of Pakistani individuals with (n=10,000) and without (n=2,000) Bipolar Disorder (BPD). Added to Pakistani samples we are already collecting for the GEN-SCRIP project, a total of 10,000 BPD cases and 12,000 controls will be included in genome-wide association studies and these data will be contributed to the Psychiatric Genomics Consortium (PGC) and to the Database of Genotypes and Phenotypes (dbGaP). In Pakistan, consanguineous marriages are common and as a result we will be able to examine recessively inherited variants, in addition to additive model of inheritance.

PI_NAMEs: KNOWLES, JAMES A (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Adoption;Affect;Biological;Bipolar Disorder;Caucasians;causal variant;Cells;Characteristics;cohort;Cohort Studies;Collection;Communities;comparison control;Consanguinity;Consent;Copy Number Polymorphism;cost;Data;Data Analyses;data sharing;database of Genotypes and Phenotypes;Deposition;design;Disease;DNA;DSM-IV;effective therapy;Ethnic Origin;European ancestry;Family;family genetics;Family Sizes;Follow-Up Studies;Funding;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genetic variant;Genome;genome wide association study;genomic locus;Genomics;Genotype;Goals;Haplotypes;Human Genetics;Human Inbreeding;Individual;Inherited;Intellectual functioning disability;Intervention;Interview;Interviewer;Linkage Disequilibrium;Manic Disorder;Maps;Mental disorders;Modeling;National Institute of Mental Health;neural circuit;Pakistan;Patients;Phenotype;phenotypic data;Population;Population Group;population stratification;Proteins;psychiatric genomics;Psychiatrist;Psychiatry;psychogenetics;public repository;Recontacts;Recording of previous events;repository;Research;Risk;Running;Sample Size;Sampling;Schizoaffective Disorders;Schizophrenia;schizophrenia risk;screening;Site;South Asian;Structure;Target Populations;Testing;Training;trait;Transcript;treatment strategy;Twin Multiple Birth;Variant;Vertebral column;working group

PROJECT_TITLE: The GEN-BLIP Study (GENetics of BipoLar Disorder In Pakistan)

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: This competing renewal resubmission for continued NIH support of the Columbia University Graduate Training Program in Microbiology and Immunology is relevant to the public health mission of NIAID in its support of research into microbial systems and immune responses that are mounted to counter host perturbations including infection, cancer, and transplantation. Our predoctoral trainees receive a unique opportunity to obtain individualized training within a broad yet cohesive program of scientific inquiry into the immune system, host response to infection, pathogen biology, systems approaches to microbiology and immunology, cancer immunology, human immunology, and processes of microbial and immune cell replication. Our PhD program is designed to provide trainees with the skills and knowledge needed to become future innovators in microbiology and immunology and to contribute to the NIH mission to improve human health through scientific research.

PI_NAMEs: BASU, UTTIYA  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: MORGANTOWN

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative Synaptic zinc is a powerful neuromodulatory neurotransmitter. Since disruptions of synaptic zinc signaling lead to a range of sensory and behavioral deficits and mutations in zinc transport proteins are linked with schizophrenia and autism, we seek to uncover mechanisms by which synaptic zinc shapes neuronal processing.

PI_NAMEs: ANDERSON, CHARLES  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: AMPA Receptors;Auditory area;auditory processing;autism spectrum disorder;awake;Basal Ganglia;Behavioral;Biological Assay;Brain;Brain region;Calcium;Carrier Proteins;design;Glutamates;Goals;high throughput screening;Hippocampus;Human;Image;Impaired cognition;In Vitro;in vivo;insight;Knockout Mice;Lead;Link;link protein;Mediating;Mus;Mutation;N-Methyl-D-Aspartate Receptors;Nervous System Disorder;neural;Neurons;neuroregulation;Neurotransmitters;novel;optogenetics;Pathologic;Population;Preparation;presynaptic;response;Role;Schizophrenia;Sensory;Sensory impairment;Shapes;Signal Transduction;SLC30A3 gene;Slice;Structure;Synapses;Synaptic Transmission;Synaptic Vesicles;tool;transmission process;two-photon;Zinc;zinc-binding protein

PROJECT_TITLE: Synapse-specific effects of synaptically released zinc: implications for auditory processing


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The role of the rich vestibular efferent innervation, which provides feedback inputs from the brain stem to the vestibular peripheral sensory epithelia is not known. The present proposal uses new methods to investigate changes in afferent response properties mediated by the cholinergic and GABAergic inputs at the cellular, systemic and behavioral levels. Results will provide a better understanding of the function of the efferent vestibular system and the basis for new pharmacological approaches for improving compensation in patients with vestibular dysfunction.

PI_NAMEs: SADEGHI GHANDEHARI, SOROUSH  (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Accidents;Acetylcholine;Affect;afferent nerve;Agonist;antagonist;Behavioral;behavioral outcome;behavioral response;Bilateral;Brain Stem;Butyric Acids;Cells;Cessation of life;cholinergic;Cholinergic Fibers;Cholinergic Receptors;Code;Compensation;Crista ampullaris;Development;Drug usage;Ear;Efferent Pathways;Electrophysiology (science);Epithelium;Equilibrium;exercise rehabilitation;extracellular;falls;Feedback;Fiber;Frequencies;functional improvement;Goals;Hair Cells;Head Movements;improved;In Vitro;in vivo;Injections;Knowledge;Laboratories;Labyrinth;Learning;Lesion;Link;macula;Measures;Mediating;Membrane;Methods;multisensory;Mus;Muscarinic Acetylcholine Receptor;nerve supply;neuromechanism;Neurotransmitters;Nicotinic Receptors;older adult;Optics;optogenetics;Organ;patch clamp;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Positioning Attribute;posture instability;Preparation;Probability;Property;receptor;Research;response;Role;Rotation;sensor;Sensory;Signal Transduction;Source;Supporting Cell;Synapses;System;Testing;tool;transmission process;United States;Vestibular Diseases;Vestibular dysfunction;Vestibular function;Vestibular Hair Cells;Vestibular Nerve;vestibular pathway;vestibular reflex;vestibular system;vestibulo-ocular reflex

PROJECT_TITLE: Modulation of vestibular afferent properties by cholinergic and GABAergic inputs: from neural mechanisms to behavioral outcomes

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: UNIVERSITY-WIDE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative  This fellowship application proposes training and research to understand how people form impressions of one another when they interact through text or video, in behavior and in the brain. These processes pose critical difficulties for a range of psychiatric illnesses, such as autism spectrum disorder, schizophrenia, and depression. Understanding the cognitive and neural mechanisms in healthy individuals will provide the applicant with important tools and background for future studies in psychiatric populations.

PI_NAMEs: ROUHANI, NINA  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Adult;Auditory;autism spectrum disorder;Behavior;Behavioral;Behavioral Model;Brain;Brain region;Cognitive;Computer Models;Computer Vision Systems;computerized tools;Consensus;deep neural network;Dimensions;dyadic interaction;Face;Face Processing;Facial Expression;feature extraction;Fellowship;Friends;Functional Magnetic Resonance Imaging;Future;Genetic Transcription;Gestures;Goals;Human;human data;impression;Individual;Individual Differences;individuals with autism spectrum disorder;Judgment;Learning;Life;Linear Regressions;Link;machine learning method;Mental Depression;Mental disorders;mental state;mentalization;Methods;Mind;model building;Modeling;Modernization;Natural Language Processing;neural;neural patterning;neuroimaging;neuromechanism;Participant;Pattern;Persons;Population;Postdoctoral Fellow;Poverty;predictive modeling;Process;psychologic;recruit;Research;response;Scanning;Schizophrenia;Semantics;skills;social;social cognition;Social Interaction;Source;Speech;Stereotyping;Stimulus;System;Text;Time;tool;Training;trait;Translating;trustworthiness;Update;Validation;video chat;Video Recording;Visual;Weight;Work

PROJECT_TITLE: Dissecting the features and neural mechanisms supporting naturalistic social inference


NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Aberrant glycosylation is a hallmark of cancer and contributes to the ability of transformed cells to escape immune surveillance and proliferate uncontrollably. However, mechanisms underlying these processes are not well understood, in part because glycosylation is exceptionally difficult to study. To bridge this disparity, we strive to understand how glycosylation contributes to downregulation of immune signaling, how altered glycans vary spatially within and around tumors, and how data processing can be streamlined in glycoproteomic experiments. .

PI_NAMEs: MALAKER, STACY ALYSE (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Address;Algorithmic Software;Binding;Biochemical;Biochemistry;Bioinformatics;Biological;cancer immunotherapy;cell transformation;Chemicals;computerized data processing;Data;Disparity;Down-Regulation;Engineering;Enzymes;Event;experience;experimental study;Galactose Binding Lectin;Glycoproteins;glycoproteomics;glycosylation;Goals;Image;Immune checkpoint inhibitor;Immune Evasion;Immune signaling;Immunoglobulins;Immunologic Surveillance;Immunology procedure;information gathering;insight;interdisciplinary approach;Investigation;Knowledge;Laboratories;Ligand Binding;Ligands;Malignant - descriptor;Malignant Neoplasms;Manuals;mass spectrometric imaging;Mass Spectrum Analysis;Membrane Glycoproteins;Methods;Modification;mucinase;Mucins;novel;Peptide Hydrolases;Polysaccharides;Process;programs;Proliferating;protein function;Proteins;Resolution;Role;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;Structure;T-Cell Activation;T-Lymphocyte;Tissues;tumor;tumor microenvironment;tumor progression;Validation;Visualization

PROJECT_TITLE: Toward understanding the role of altered glycosylation in cancer


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Neurosciences;Radiation Oncology;Rare Diseases

PHR: Project Narrative In proton magnetic resonance spectroscopy (MRS) of the human brain, signals arise both upfield (UF) and downfield (DF) from the water resonance and while UF MRS have been extensively studied in humans over the last 30 years, there have been very few DF studies and all of them used single voxel localization. The proposed career development activities will establish a smooth transition to an independent scientific career in biomedical imaging and bioengineering including the research project for development of novel MR spectroscopic imaging (MRSI) techniques and clinical applications. Brain metabolism in DF will be assessed in a cohort of healthy subjects to provide a normative database and brain tumor patients to predict tumor recurrence versus radiation necrosis using multimodal metabolic imaging approach (MRSI and chemical exchange saturation transfer, CEST), and modern statistical techniques in a combined software framework for the ultimate translation into clinical practice as well as identification of biomarkers for personalized evaluation of patients for improved diagnosis and treatment monitoring (precision medicine).

PI_NAMEs: ÖZDEMIR, İPEK  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Adult;Age;age difference;Amides;Award;Bioinformatics;biomarker identification;Biomedical Engineering;biomedical imaging;Biometry;Biopsy;Brain;Brain imaging;brain metabolism;Brain Neoplasms;career;career development;Characteristics;Chemicals;chemoradiation;Clinical;clinical application;clinical practice;Clinical Research;cohort;Communities;Complement;Computer software;Data;Data Analyses;Databases;Detection;Development;Diagnosis;Diagnostic;Evaluation;follow-up;Glioma;Goals;Grant;healthy volunteer;Human;human imaging;Image;image processing;imaging approach;imaging modality;Imaging Techniques;improved;in vivo;Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Maps;Measures;Mentors;metabolic abnormality assessment;metabolic imaging;Metabolism;Methodology;Methods;Modernization;Monitor;MRI Scans;multimodality;Neurologic;neuropathology;Neurosciences;Noise;novel;open source;Outcome;Pathway interactions;Patients;Performance;personalized biomarkers;Phase;Physiologic pulse;Pilot Projects;precision medicine;Prediction of Response to Therapy;Process;Protons;Publications;Publishing;Radiation necrosis;reconstruction;Recurrent tumor;Relaxation;Reproducibility;Research;Research Project Grants;Resolution;Resource Development;Route;Scanning;Signal Transduction;skills;Slice;Software Framework;Software Tools;spectroscopic imaging;System;Techniques;Time;time use;Tissues;tool;Training;training opportunity;Translations;treatment choice;tumor diagnosis;Universities;Visualization;Water

PROJECT_TITLE: Downfield MR spectroscopic imaging of the human brain


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative RNA-targeting gene therapies that precise tune gene expression at the transcript level can address the shortfalls and challenges of current gene therapies, but the large size and microbially-derived nature of existing programmable RNA-targeting systems preclude broad clinical utility. Constructed from human protein parts, CIRTS (CRISPR/Cas-inspired RNA targeting system) offers a therapeutically actionable solution to these hurdles. Here, we will use biochemical engineering approaches to generate highly efficient RNA-targeting CIRTS activators and degraders and prioritize those with optimized performance parameters using a combination of disease-relevant target gene assays and in vivo immunogenicity studies.

PI_NAMEs: DICKINSON, BRYAN  (contact)

PROGRAM_OFFICER_NAME: DARINGER, NICHOLE MARIE

PROJECT_TERMS: Address;Affect;alpha synuclein;Back;Bacteria;Benchmarking;Binding;Biochemical;Biological;Biological Assay;Biomedical Research;Brain;Cardiovascular Diseases;Cell model;cell type;Cells;Chicago;Clinical;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;Custom;Data;delivery complications;design;design,build,test;Disease;disorder control;Dose;efficacy testing;Elements;Engineering;epitranscriptomics;Event;experimental study;functional outcomes;Gene Activation;Gene Dosage;Gene Expression;gene product;gene repression;gene therapy;gene-targeted therapy;Genes;Genetic;Genetic Diseases;genetic manipulation;Goals;Grant;Guide RNA;Health;Homeostasis;Human;Human Engineering;Immune;immunogenic;immunogenicity;improved;in vivo;Individual;interest;Lead;Liver;Luciferases;Malignant Neoplasms;Mediating;Messenger RNA;Metabolic Diseases;Methods;microbial;Mining;mouse model;multimodality;Nature;Neuropathy;novel;Outcome;overexpression;Patients;Performance;PMP22 gene;pre-clinical;Predisposition;preference;Protein Engineering;Proteins;Proteome;Reader;Regulation;Regulatory Pathway;relative effectiveness;remediation;Reporter;Reproducibility;Risk;RNA;RNA Degradation;RNA Interference;screening;Side;Site;Specificity;stem;synthetic biology;System;system architecture;Technology;technology platform;Testing;Therapeutic;Tissues;Transcript;transcriptome;Translational Activation;Universities;Untranslated Regions;Validation;Work

PROJECT_TITLE: Engineering human-derived programmable RNA effectors to retune gene expression

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Relevance Statement Leptin is unquestionably a major driver of systemic metabolic well-being. However, the use of recombinant leptin as a therapeutic agent is extremely limited. This is due to widespread leptin resistance, observed even after moderate increases in leptin. We determined that reducing leptin concentrations in circulation results in a dramatic improvement in leptin sensitivity, which leads to an immediate increase in insulin sensitivity. The studies we propose here are aimed to a) better understand the mechanistic aspects of this leptin sensitization; b) determine which anti-diabetic pharmacological treatment regimens rely on a leptin-lowering effect to achieve their established action, and c) gain a better understanding of the regulation of leptin production at the level of different fat-pads. As such, the proposed studies are of immediate relevance for both clinical applications of neutralizing leptin antibody preparations, as well as the basic understanding of leptin production and action.

PI_NAMEs: ELMQUIST, JOEL K.;SCHERER, PHILIPP E (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acute;Address;Adipocytes;adipokines;adiponectin;Adipose tissue;Adrenergic Receptor;Adult;adult obesity;Affect;Agonist;Animals;Anti-diabetic Drugs;Antibodies;Area;blood glucose regulation;Body Weight;Body Weight decreased;Brain;brain tissue;Cellular Metabolic Process;Chronic;Circulation;clinical application;Closure by clamp;diet-induced obesity;Eating;Energy Metabolism;experimental study;Fatty acid glycerol esters;FGF21 gene;fibroblast growth factor 21;Food Energy;Food Intake Regulation;GCG gene;Genes;Genetic Transcription;Glucagon;Glucose;Hand;Homeostasis;Hypothalamic structure;improved;in vivo;Individual;inhibitor;insight;Insulin Resistance;insulin sensitivity;insulin sensitizing drugs;insulin signaling;Intervention;Laboratories;Leptin;Leptin deficiency;leptin receptor;Leptin resistance;Ligands;Lipids;Lipodystrophy;LoxP-flanked allele;Mediating;Mediator;Metabolic;Metabolic Control;Metabolic Diseases;metabolic profile;Metabolism;Metformin;Modeling;Monitor;mouse model;Nature;Neurons;Obesity;Organ;overexpression;Peptides;Peripheral;Personal Satisfaction;pharmacologic;Pharmacological Treatment;Physiological;Physiology;Plasma;Play;Population;Positioning Attribute;predictive modeling;Preparation;Pro-Opiomelanocortin;Process;Production;Publishing;Recombinants;Records;Regimen;Regulation;Reporter;response;Role;Series;sexual dimorphism;Signal Transduction;success;Sympathetic Nervous System;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;Time;Tissues;tool;Transgenic Organisms;Treatment Protocols;Visceral;Work

PROJECT_TITLE: Metabolic Benefits of Leptin Reduction

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ORG_CITY: NEW YORK

PHR: Project Narrative  Heart failure is associated with unacceptably high morbidity and mortality worldwide despite currently available medical and device therapies, highlighting the need for deep mechanistic research in this field. Dead box helicase (Ddx) proteins play important roles in RNA splicing and processing. A key member of this protein family, Ddx5 has not been studied in the heart, and in this proposal, we will elucidate its role in cardiac function and disease.

PI_NAMEs: TOPKARA, VELI KEMAL (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Affect;Alternative Splicing;American;aorta constriction;Atherosclerosis;Attenuated;Binding;Biogenesis;Biological;Biological Assay;Calcium;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cells;Chronic;Clinical Investigator Award;Co-Immunoprecipitations;Complex;Data;Defect;Dependovirus;Devices;Dilated Cardiomyopathy;Disease;Down-Regulation;Dystrophin;experimental study;Functional disorder;gene therapy;Genes;Genetic Transcription;global health;Goals;Heart;Heart Diseases;Heart failure;heart function;helicase;Heterogeneous-Nuclear Ribonucleoproteins;Homeostasis;hospitalization rates;Human;human disease;human induced pluripotent stem cells;human model;Immunoprecipitation;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;Injections;Injury;insight;Knockout Mice;Label;Laboratories;Left Ventricular Remodeling;Luciferases;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medical;member;Messenger RNA;micro-dystrophin;mini-dystrophin;Morbidity - disease rate;mortality;mouse model;mRNA Precursor;mRNA Stability;Mus;Muscle Development;mutant;Myocardial;Nonsense-Mediated Decay;novel;novel therapeutic intervention;novel therapeutics;overexpression;Pathogenesis;Pathologic;Patients;Phenotype;Physiological;Play;Population;Post-Transcriptional Regulation;posttranscriptional;pressure;prevent;Protein Family;Proteins;Proteomics;Recovery;Regulation;Reporter;Research;Ribosomes;RNA;RNA Helicase;RNA metabolism;RNA Processing;RNA Splicing;Role;RyR2;Sarcomeres;Signal Transduction;Skeletal Muscle;Stress;Tail;Testing;Therapeutic;Tissues;Transcript;Transcriptional Regulation;transcriptional reprogramming;transcriptome sequencing;transcriptomics;Transgenic Organisms;Translations;United States National Institutes of Health;Untranslated RNA;vector;Veins;virtual;Wild Type Mouse

PROJECT_TITLE: Role of RNA helicase Ddx5 in pathological cardiac remodeling

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Autophagy is a lysosomal degradation pathway that is essential for neuronal homeostasis and survival. Deficits in autophagy lead to neurodevelopmental abnormalities and neurodegeneration in mammals, but little is known about the functions and regulation of autophagy that provide neuroprotection. This proposal will determine the roles and regulation of neuronal autophagy that facilitate neuronal function and survival, and inform strategies to therapeutically modulate autophagy for beneficial outcomes in disease.

PI_NAMEs: MADAY, SANDRA L. (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Affect;Age-associated memory impairment;Astrocytes;Autophagocytosis;Autophagosome;Axon;Biochemistry;Biological Models;Biology;Birth;Brain-Derived Neurotrophic Factor;cell age;Cells;Cellular biology;Coculture Techniques;Complex;Cues;Data;Defect;Degradation Pathway;Dendrites;density;Disease;Distant;Electrophysiology (science);Environment;experimental study;Gene Expression;Genes;Goals;Hippocampus;Homeostasis;Human;improved;insight;knock-down;Lead;Learning;Link;Lysosomes;Mammals;Maps;Measures;Mediating;Memory;Metabolism;Modeling;Molecular;Morphology;Motility;Movement;mTOR inhibition;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;neuron development;neuronal cell body;Neuronal Dysfunction;neuronal survival;Neurons;neuroprotection;Neurosciences;neurotrophic factor;Outcome;Pathway interactions;Phenotype;Play;polarized cell;Population;postsynaptic;Presynaptic Terminals;Process;programs;Property;Regulation;Research;response;retrograde transport;Role;Signal Transduction;Starvation;Stress;Synapses;synaptic function;Techniques;Testing;Therapeutic;Therapeutic Intervention;Time;Translations;Vacuole;Work

PROJECT_TITLE: Defining the roles and regulation of neuronal autophagy

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Women's Health Research

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative  We propose to develop an intelligent-augmented risk assessment system for breast cancer management based on multimodality image and clinical information with deep learning and data mining techniques. Using mammographic or breast ultrasound BI-RADS reporting signatures and radiomics features, a more precise and clinically relevant predictive model will be developed to target well-characterized and defined specific biopsy patient subgroups rather than a broad heterogeneous biopsy group. The more reliable stratification of BI-RADS subtypes for breast cancer risk assessment will reduce the number of unnecessary breast biopsies and save billions of dollars in medical costs annually.

PI_NAMEs: WONG, STEPHEN TC (contact)

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Address;American College of Radiology;Anxiety;Architecture;Artificial Intelligence;Artificial Intelligence enhanced;augmented intelligence;autoencoder;Awareness;Benign;Biopsy;Breast;Breast biopsy;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer Treatment;breast imaging;calcification;cancer diagnosis;Cancer Etiology;cancer risk;cancer subtypes;cancer type;Categories;Characteristics;Clinical;clinical data warehouse;Clinical Pathology;Clinical Research;clinical risk;Clinical/Radiologic;clinically relevant;Communication;Core Biopsy;cost;Data;data mining;Databases;Decision Making;deep learning;deep learning algorithm;deep learning model;demographics;density;Development;Diagnostic;Digital Breast Tomosynthesis;Evaluation;follow-up;Hospitals;Hybrids;Image;image processing;imaging facilities;improved;Information Systems;Interobserver Variability;Joints;Lead;Lesion;Link;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Ultrasonography;Mammography;Measures;Medical Care Costs;Medical Imaging;Methodist Church;Methods;Modeling;Molecular;multimodal data;Multimodal Imaging;multimodality;Names;Natural Language Processing;novel;novel strategies;Observational Study;Oncologist;Operative Surgical Procedures;Output;Pain;Pathologic;Pathology;patient subsets;Patients;Performance;Physicians;Picture Archiving and Communication System;predictive marker;predictive modeling;Probability;Prognostic Marker;prospective;radiologist;Radiology Specialty;radiomics;Recommendation;Reporting;Research Personnel;Retrieval;Risk Assessment;Risk Factors;Risk Management;Risk Reduction;risk stratification;screening;Standardization;Stratification;System;Techniques;Technology;Testing;tool;Training;two-dimensional;Ultrasonography;United States;Variant;web app;women patients;Women's mortality

PROJECT_TITLE: Convergent AI for Precise Breast Cancer Risk Assessment

STUDY_SECTION: BCHI

STUDY_SECTION_NAME: Biomedical Computing and Health Informatics Study Section[BCHI]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Eye Disease and Disorders of Vision;Multiple Sclerosis;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE The mammalian brain and spinal cord consist not only of neurons, but additional specialized cell types called oligodendrocytes and astrocytes. These cells play critical roles in regulating neurological function and there is strong evidence that their loss or dysfunction contribute to an increasing list of diseases including multiple sclerosis, pediatric leukodystrophies, and Alzheimer’s disease. The goal of this proposal is to leverage the innovative approaches developed in our lab to define the mechanisms that regulate oligodendrocyte and astrocyte function and discover new therapeutic approaches to restore neurological deficits in patients.

PI_NAMEs: TESAR, PAUL JOSEPH (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Alzheimer's Disease;Astrocytes;Blindness;Brain;cell type;Cells;Central Nervous System;Childhood;Development;Disease;disease model;experience;Fatigue;Functional disorder;Goals;Health;Human;human stem cells;Impaired cognition;improved;In Vitro;innovation;innovative technologies;leukodystrophy;mouse model;Multiple Sclerosis;multiple sclerosis patient;Mus;Myelin;myelination;Natural regeneration;Nervous System Disorder;Nervous System Physiology;Neurologic Deficit;Neuromyelitis Optica;Neurons;novel;novel therapeutic intervention;novel therapeutics;Oligodendroglia;Paralysed;Patients;Play;prevent;regenerative approach;Role;small molecule;Spinal Cord;stem cell biology

PROJECT_TITLE: Modulating Glial Fate and Function in Development and Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Prevention;Suicide;Suicide Prevention;Violence Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: When faced with a crisis, some people but not others transition from thinking about suicide to acting on these thoughts. This project will use a formal theoretical framework combined with electroencephalography to test the hypothesis that individuals at risk for suicide become cognitively overwhelmed under challenging life circumstances and make poor choices as a result. The anticipated impact of this proposal includes the identification of more precise targets for cognitive clinical interventions.

PI_NAMEs: TSYPES, ALIONA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Affect;Affective;aged;Area;Behavior;Behavioral;Behavioral Model;career development;Central Nervous System;Clinical;Clinical Data;Clinical Research;Cognitive;cognitive control;community setting;Computer Models;Decision Making;Dimensions;Disease susceptibility;Dissociation;Electroencephalography;Electrophysiology (science);Environment;Event;Evolution;Exhibits;experience;Faculty;Failure;falls;Feedback;Feeling suicidal;Funding;Future;Goals;help-seeking behavior;ideation;Impairment;indexing;Individual;Individual Differences;Inpatients;insight;interest;Intervention;Interview;Knowledge;Learning;Life;Literature;Magnetoencephalography;Mathematics;Measures;Mentorship;millisecond;Modeling;Moods;National Institute of Mental Health;neural;neural model;Neurons;Neurosciences;Outcome;Outpatients;Parietal;Participant;Patient Self-Report;Persons;Population;pressure;Prevention;Process;Productivity;programs;Psychiatry;psychologic;Psychological reinforcement;Psychopathology;Recording of previous events;recruit;Research;Research Domain Criteria;Resolution;Resources;response;Rewards;Role;Short-Term Memory;Specific qualifier value;Stress;suicidal behavior;suicidal individual;suicidal risk;Suicide;Suicide attempt;suicide attempter;suicide model;Suicide prevention;System;Techniques;Testing;theories;Thinking;Time;Training;trait;Translating;transmission process;Uncertainty;Universities;Update;verbal;Vision;Work

PROJECT_TITLE: Cortical oscillatory dynamics and decision deficits in suicidal behavior - Resubmission

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Unintentional Childhood Injury

ORG_NAME: HUGO W. MOSER RES INST KENNEDY KRIEGER

PHR: PROJECT NARRATIVE Neonatal brain injury from extremely preterm birth causes significant life-long neurodevelopmental delays and impaired structural brain development. This proposal will determine the role of fatty acids in the brain post- injury, which will aid in creating new therapeutic and dietary strategies for treatment. Therefore, this proposed research is relevant to the NIH mission to reduce the burden of neurological injury and promote functional recovery.

PI_NAMEs: SCAFIDI, JOSEPH  (contact);SCAFIDI, SUSANNA

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;acylcarnitine;behavioral study;Biochemical;Brain;Brain Injuries;brain metabolism;Brain region;Carnitine Palmitoyltransferase I;Cell Maturation;Cells;Cerebrum;Clinical Management;Critical Pathways;Data;density;Dependence;Development;dietary;Energy-Generating Resources;Ensure;Equilibrium;Essential Fatty Acids;experience;extreme prematurity;Failure;fatty acid metabolism;fatty acid oxidation;Fatty Acids;fetal;flexibility;functional outcomes;Genes;Glucose;Goals;Growth;Hippocampus;Histologic;Hypoxia;Image;Impairment;improved;inducible Cre;Inflammatory;inflammatory marker;Injury;Knowledge;Life;Lipid Peroxidation;Lipids;mass spectrometric imaging;Measures;Membrane Lipids;Metabolic;Metabolism;migration;Mission;Mitochondria;myelination;Neonatal;Neonatal Brain Injury;neonatal period;nerve stem cell;Nervous System Trauma;neural;neurobehavioral;neurogenesis;Neurological outcome;new therapeutic target;novel therapeutics;Organ;Outcome Study;oxidation;Pathway interactions;Phase;Phenotype;Play;Population;postnatal;Premature Birth;Process;Production;Proliferating;Proteins;Reactive Oxygen Species;Recovery;Recovery of Function;Research;response;response to injury;RNA;Role;Science;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;stem;stem cells;subventricular zone;tandem mass spectrometry;Testing;Therapeutic;Time;treatment strategy;United States National Institutes of Health;white matter

PROJECT_TITLE: Coordination of fatty acid metabolism following neonatal brain injury from preterm birth


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE  This proposal studies Cryptococcus neoformans, a leading cause of fungal infections acquired by inha- lation and responsible for hundreds of thousands of deaths yearly, towards which there is no adequate treatment. Many factors contribute to a high medical burden, but one of them is an incomplete understanding of its intracel- lular pathogenesis. By understanding the mechanisms used by this fungus to cause disease we may be able to develop new more effective treatments, making this research relevant to NIH’s public health mission and a spe- cific priority for various institutes such as NHLBI or NIAID. Lastly, this work will also contribute to basic science knowledge, informing studies of other pathogenic microbes and areas of cell biology.

PI_NAMEs: SANTIAGO-TIRADO, FELIPE H (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Area;Basic Science;Behavior;Biochemical;Biological;Biology;Buffers;capsule;Cause of Death;Cells;Cellular biology;Cessation of life;Characteristics;Clinical Research;Cryptococcus;Cryptococcus neoformans;Data;Development;Disease;Disease Progression;Early Endosome;effective therapy;Foundations;Fungal Genes;fungal genetics;fungus;Generations;Genetic;Genetic Techniques;Geographic Locations;Glucuronic Acids;Goals;Hyaluronic Acid;Hybrids;Image;Immune;Immune Evasion;Immune signaling;Immune system;Immunocompromised Host;Immunologic Techniques;immunological status;Immunologics;Incidence;Infection;Inflammatory;Inhalation;Intervention;Investigation;Knowledge;Link;Lysosomes;Macrophage;Mammalian Genetics;Mediating;Medical;Membrane;Microscopy;Mission;Modeling;Molecular;mortality;mutant;Mycoses;National Heart, Lung, and Blood Institute;National Institute of Allergy and Infectious Disease;Outcome;pathogen;Pathogenesis;pathogenic fungus;pathogenic microbe;Patients;Permeability;permissiveness;Phagosomes;Phenotype;Phosphatidylinositols;Population;prevent;Prevention;Process;Property;Public Health;rab GTP-Binding Proteins;Reporting;Research;Resolution;Role;Signal Transduction;Surface;Techniques;Testing;Therapeutic Intervention;therapeutically effective;United States National Institutes of Health;Work;Yeasts

PROJECT_TITLE: Host and fungal factors important for the cryptococcal intracellular niche

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Methamphetamine;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Understanding the interaction of biological and behavioral risk factors for HIV/STI transmission caused by methamphetamine use is imperative for effective HIV/STI interventions. This innovative project will evaluate the joint effects of methamphetamine use, HIV, sexual risk behavior, and rectal GC/CT on systemic and rectal inflammation – a key step in designing potent prevention interventions. Findings from this project will be important toward the development of effective interventions that combine methamphetamine reduction with STI screening and HIV prevention.

PI_NAMEs: BLAIR, CHERIE SAVINE (contact)

PROGRAM_OFFICER_NAME: JENKINS, RICHARD A

PROJECT_TERMS: Acute;addiction;Adherence;AIDS prevention;Area;Attenuated;Behavior;Behavioral;biobehavior;Biological;Biological Markers;Biology;career;Chlamydia;Clinic;Clinical Trials;cohort;Communicable Diseases;Communities;condomless anal sex;contingency management;cytokine;Data;design;Development;drug abstinence;effective intervention;efficacy testing;Epidemic;Evidence based intervention;Frequencies;Funding;Future;Goals;Gonorrhea;HIV;HIV Infections;HIV risk;HIV Seronegativity;HIV Seropositivity;Immune;Immunology;Impact evaluation;Impairment;Inflammation;Inflammatory;inflammatory marker;innovation;Intervention;Investigation;Joints;K-Series Research Career Programs;Link;Longitudinal Studies;Measures;Medicine;men who have sex with men;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methamphetamine;Methamphetamine dependence;methamphetamine effect;methamphetamine exposure;methamphetamine use;Methods;Modification;Mucositis;Mucous Membrane;multidisciplinary;multimodality;National Institute of Drug Abuse;novel;operation;Participant;Pharmaceutical Preparations;Plasma;pre-exposure prophylaxis;Prevention strategy;preventive intervention;procedure safety;Proctitis;recruit;rectal mucosa;Rectum;Reporting;Research;Research Personnel;responsible research conduct;Rewards;Risk;Risk Behaviors;Risk Factors;Risk Reduction;screening;Sex Behavior;Sexual Partners;sexual risk behavior;Sexually Transmitted Diseases;skills;Specimen;Statistical Methods;statistics;substance use;Swab;systemic inflammatory response;tool;Training;transmission process;Universities;Urine;Viral Load result;Visit

PROJECT_TITLE: Effects of methamphetamine use on risk behavior, systemic and mucosal inflammation, and sexually transmitted infection (STI)/HIV risk among men who have sex with men

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Eye Disease and Disorders of Vision

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: This project aims to develop a compact Braille electronic display panel comprised of an array of dots that can be programmed to display Braille text and topographical patterns for alphanumerics and symbols. The tactile contents can be refreshed akin to visual images on a smartphone screen. 1

PI_NAMEs: PEI, QIBING  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Access to Information;Aging;Architecture;Automobile Driving;blind;braille;Braille Display;Cells;Cellular Phone;Child;Communication;copolymer;cost;Data;design;Development;Device or Instrument Development;Devices;Education;Educational process of instructing;Electrodes;Electronics;Employment;energy efficiency;Ensure;Evaluation;Exhibits;experience;Feedback;Focus Groups;Heating;Height;Image;improved;Individual;innovation;Learning;Legal Blindness;legally blind;Length;literacy;manufacturing cost;Maps;Marketing;Membrane;Methods;Modernization;Modulus;Names;Pattern;Performance;Persons;Phase;phase change;Polymers;power consumption;pressure;Process;prototype;Reader;Reading;Relaxation;Resistance;Resolution;sample fixation;Scheme;Shapes;Societies;Speed;Structure;success;Surface;Surveys;Tablets;Tactile;tactile display;Target Populations;Techniques;Technology;Temperature;Text;Thick;Time;Transition Temperature;Travel;United States;usability;Visual;Visual impairment;Visually Impaired Persons;voltage;Work;Writing

PROJECT_TITLE: A High Resolution Tactile Display Based on Variable Stiffness Polymer and Pneumatic Actuation


NIH_SPENDING_CATS: Biotechnology;Genetics;Infant Mortality;Infectious Diseases;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_STATE: PA

PHR: Narrative Group B Streptococcus (GBS) causes serious infections during and shortly after pregnancy, which endanger mothers, fetuses, and newborns. GBS is exceptional in its ability to persist and grow in the pregnant uterus, and existing evidence suggests that one reason for this is that GBS can suppress and evade components of the gestational innate immune system, which typically serve to clear bacterial invaders while supporting healthy fetal development. In this project, our collaborative group will use novel genetic tools to examine how GBS affects key immune cells—called macrophages—in the placenta. We are searching for new targets on the surface of GBS cells that participate directly in subverting immune defenses, and which could pave the way for new preventative or therapeutic strategies to protect pregnant women and their newborns from these dangerous bacteria.

PI_NAMEs: ARONOFF, DAVID M;HOOVEN, THOMAS A (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Adverse event;adverse pregnancy outcome;Affect;Alleles;Amniotic Fluid;Animal Model;Anti-Inflammatory Agents;antimicrobial;Bacteria;Bacterial Genes;Binding;Binding Proteins;Candidate Disease Gene;candidate identification;capsule;Cell Wall;Cells;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;complement 4b-binding protein;Complement 5a;complement system;Complex;Confocal Microscopy;CRISPR interference;cytokine;Dangerousness;Defect;delivery complications;density;Detection;Disease;early onset sepsis;Early treatment;Etiology;experimental study;fetal;Fetal Development;Fetus;Gene Deletion;Gene Expression;Generations;Genes;Genetic;Goals;Growth;Health;high reward;high risk;Homeostasis;Human;Hyaluronidase;Immune;Immune Evasion;Immune response;Immunologic Surveillance;Immunophenotyping;in vivo;Incubated;Infection;Inflammatory;Inflammatory Response;Innate Immune System;innovation;interest;Interleukin-1 beta;intraamniotic infection;intrauterine infection;Invaded;knock-down;Lead;Libraries;Life;Macrophage;Macrophage Activation;Maternal-Fetal Exchange;Measurement;Mediating;Microbe;microbial;Modeling;Molecular Mimicry;Mothers;mouse model;multimodality;Mus;mutant;Natural Immunity;neonatal sepsis;Newborn Infant;novel;novel therapeutics;novel vaccines;Outcome;pathogen;Pathogenesis;Peptide Hydrolases;Phagocytes;Phagocytosis;Placenta;Play;Polysaccharides;post pregnancy;Predisposition;Pregnancy;Pregnant Uterus;Pregnant Women;Premature Birth;Premature Labor;Prevention;Production;Protein Secretion;Proteins;Reactive Oxygen Species;Receptor Signaling;response;Role;Sialic Acids;Signal Transduction;single-cell RNA sequencing;Sorting;stillbirth;Streptococcal Infections;Streptococcus CAMP protein;Streptococcus Group B;Surface;Techniques;Testing;Therapeutic;Time;Tissues;TNF gene;tool;United States;Vagina;Virulence;Western Blotting;Work

PROJECT_TITLE: Bacterial CRISPR interference to define macrophage responses to group B Streptococcus proteins

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB

PHR: Project Narrative By establishing the Phenix R24 Resource we will maintain and disseminate the Phenix software and cctbx library for crystallographic and cryo-EM structure determination. This we enable researchers to generate better, more chemically reasonable atomic models, which will help improve their fundamental understanding of biological systems. Better models will also enable scientists to develop improved therapeutics for human health.

PI_NAMEs: ADAMS, PAUL DAVID (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: 3-Dimensional;Address;Adherence;Awareness;base;Biological;biological systems;Chemicals;Code;Communities;Complex;Computer software;Cryoelectron Microscopy;Crystallography;Data;Data Analyses;data modeling;Data Science;Data Set;data standards;Deposition;Development;Education and Outreach;Educational workshop;electron diffraction;Ensure;Environment;Event;experimental analysis;Experimental Models;FAIR principles;Funding;Goals;graphical user interface;Health;Human;human disease;improved;Infrastructure;International;Knowledge;Language;large datasets;Legal patent;Libraries;Life;literature citation;macromolecule;Maintenance;Measures;Methods;Modeling;Modernization;Modification;Molecular Structure;National Institute of General Medical Sciences;Neutron Diffraction;novel therapeutics;Online Systems;open source;operation;outreach;Play;programs;protein data bank;Publications;Pythons;R24;rapid growth;reconstruction;Research;Research Personnel;Research Support;Resources;response;Role;Schools;Scientist;Shapes;Software Tools;structural biology;Structure;symposium;System;Techniques;Testing;Therapeutic;three dimensional structure;Time;tool;Training;United States National Institutes of Health;Update;uptake;usability;Videoconferencing;Visualization;web site;Work;Writing;X ray diffraction analysis;X-Ray Crystallography

PROJECT_TITLE: Phenix: providing high quality software to the research community for crystallography and cryo-EM


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Rare Diseases;Rheumatoid Arthritis

ORG_CITY: Aurora

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Aggregating across biological datasets reveals a patchwork of different technologies and conditions of interest; however, several holes exist in this patchwork, hindering our ability to entirely utilize biological datasets that currently exist. We propose to use a special class of methods, called domain adaptation methods, that can leverage the local patterns in the patchwork to build models that can either work around the missing pieces or fill them in. To show the strength and flexibility of these approaches, we apply our methods to three biomedical application areas: 1) inferring missing cell-type-specific treatment responses in Rheumatoid Arthritis; 2) predicting the tissue-of-origin of cell-free DNA (cfDNA) from a model trained on a different but complementary data type to cfDNA; 3) predicting gene expression patterns in the bone marrow from cfDNA.

PI_NAMEs: DAVIDSON, NATALIE ROSE (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Adopted;Aftercare;Area;Atlases;Autoimmune Diseases;Beneficence;Biodiversity;Biological;Biological Markers;Biological Sciences;biological systems;Biology;Biopsy;Bone Marrow;Bone marrow biopsy;Bone Marrow Cells;Bypass;Cancer Detection;career;cell free DNA;Cell model;cell type;Cells;Cellular Assay;Chromatin;Clinical Sciences;cohort;Colorado;Computational Biology;Computational Technique;Data;Data Reporting;Data Set;Dimensions;Disease;Disease-Modifying Second-Line Drugs;Dissociation;diverse data;DNA;Emerging Technologies;Epigenetic Process;Etiology;Evaluation;experience;Face;flexibility;Foundations;Frequencies;Gene Expression Profile;generative models;genetic signature;Goals;Graft Rejection;Health;High-Throughput Nucleotide Sequencing;Incidence;Information Technology;insight;Institution;Interdisciplinary Study;interest;Learning;learning strategy;Machine Learning;Malignant Neoplasms;Masks;Measurement;Medical;Mentors;Methodology;Methods;minimally invasive;Modality;model building;Modeling;Molecular;Monitor;multiple omics;new technology;novel sequencing technology;Outcome;Patients;Pattern;Phase;Procedures;Process;progenitor;programs;Proteomics;Research;Research Personnel;Resolution;Resources;response;Rheumatoid Arthritis;RNA;Sampling;Scientist;Severities;Severity of illness;single cell sequencing;Solid;Source;stem cells;T-Lymphocyte;Techniques;Technology;Tissues;tool;Training;transcriptome sequencing;transcriptomics;Translational Research;translational research program;Transposase;treatment effect;treatment response;Universities;Work

PROJECT_TITLE: Domain adaptation approaches to unify established and emerging sequencing technologies

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Digestive Diseases;Infectious Diseases

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Human cytomegalovirus infects the majority of the American people and although it typically establishes a quiescent infection with little to no disease in most individuals, the virus is responsible for a variety of devastating sequelae in immunocompromised adults and in developing babies. Therefore, identifying the viral properties essential for replication, spread and horizontal transmission are important areas of medical science. Our studies aim to use novel cellular models to investigate the molecular mechanisms by which cytomegalovirus replicates in the salivary gland where it then gains access to fluids centrally important for horizontal transmission.

PI_NAMEs: MILLER, WILLIAM E (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: 3-Dimensional;Ablation;Adult;American;Anti-viral Agents;Area;Biological Models;Cell model;Cell Nucleus;Cells;Clinical;Collaborations;Complement;Complex;Cytomegalovirus;Cytomegalovirus Infections;Data;Defect;design;Development;Disease;Epithelial Cells;Epithelium;Exhibits;experimental study;Fetal Development;Future;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Gene Modified;Genes;Glean;Glycoproteins;Goals;Growth;HDAC1 gene;HDAC3 gene;Histone Deacetylase;Histone Deacetylase Inhibitor;Horizontal Disease Transmission;Human;Immunocompromised Host;In Vitro;in vitro Model;Individual;Infection;inhibitor;innovation;insight;Intervention;Investigation;knock-down;Leukocytes;Life;Liquid substance;Liver;lytic replication;Medical;Microcephaly;Modeling;Molecular;Movement;mutant;Neurofibromin 2;Neurologic;novel;Nuclear;Olfactory Mucosa;Oral;Organ;organ transplant rejection;overexpression;Parotid Gland;Pathogenesis;Pathologic;Persons;pharmacologic;Physiological;Physiology;Play;Population;prevent;Process;Property;Proteins;Public Health;Publishing;receptor;Regulation;Role;Saliva;Salivary;salivary cell;Salivary Glands;Science;Severities;Signal Transduction;Spleen;Study models;Submandibular gland;Testing;Tissues;trafficking;transmission process;Transplant Recipients;United States;Viral;Viral Proteins;viral rescue;viral transmission;Virus;Virus Replication;Work

PROJECT_TITLE: Investigation of the role of HDAC activity in regulation of HCMV replication in the salivary epithelium

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Genetics

ORG_CITY: CLEMSON

ORG_NAME: CLEMSON UNIVERSITY

ORG_STATE: SC

PHR: Project Narrative Splicing is the process by which introns are removed from precursor mRNA to generate productive transcripts but, if performed incorrectly, can lead to aberrant transcripts and many human diseases. The goal of this project is to understand how RNA structure influences recognition of regulatory elements. Ultimately this research strives to identify elements within precursor mRNAs that regulate splicing and develop tools that can modulate splicing in a predictable manner, revealing more about the role of RNA splicing in disease and leading to therapeutics for splicing-related disorders.

PI_NAMEs: LACKEY, LELA LYNN (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Adenosine;Alternative Splicing;Antisense Oligonucleotides;Back;Binding;Binding Proteins;Binding Sites;Code;Complex;Derivation procedure;Disease;Elements;Excision;Exons;Feedback;Genes;Goals;human disease;improved;interest;Introns;Machine Learning;Mediating;Messenger RNA;Modeling;mRNA Precursor;novel;Nucleic Acid Regulatory Sequences;Process;Productivity;protein complex;Protein Isoforms;Reaction;Regulatory Element;Research;RNA;RNA Precursors;RNA Splicing;Role;Site;Spliceosome Assembly Pathway;Spliceosomes;Structure;System;Test Result;Testing;Therapeutic;tool;Transcript;Work

PROJECT_TITLE: Pre-mRNA intronic structures in trans factor binding and alternative splicing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-I(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Recovery Support Services;Social Determinants of Health;Substance Misuse

ORG_NAME: FRIENDS RESEARCH INSTITUTE, INC.

PHR: Project Narrative  This project seeks to extend the investigator’s successful preliminary work that developed a Continuing Care mobile application (app) for probationers and parolees with substance use disorders (SUDs) who are at elevated risk of adverse health consequences such as relapse, re-arrest, and incarceration. The proposed project will enhance and finalize app development and evaluate its effectiveness in a randomized controlled trial. The project has high public health significance due to its potential to provide an accessible, easy to use recovery support tool for individuals on probation or parole that could improve their SUD treatment outcomes.

PI_NAMEs: CARSWELL, STEVEN BERNARD;GORDON, MICHAEL SCOTT (contact)

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: 2 arm randomized control trial;Address;Adoption;Adult;adverse outcome;alcohol use disorder;Ambulatory Care;arm;Attention;Behavior;behavior change;Caring;Cellular Phone;Chronic Disease;Client;Cognitive Therapy;Communities;compare effectiveness;Conduct Clinical Trials;COVID-19;Crime;criminal behavior;criminal thinking;Criminology;design;Development;Diffusion;digital intervention;digital treatment;Disparity population;Dropout;Drug abuse;Drug Screening;Drug usage;Effectiveness;effectiveness evaluation;effectiveness trial;Enrollment;Evaluation;Evidence based treatment;experience;feasibility trial;Feedback;field study;flexibility;General Population;Growth;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health Services Accessibility;High Prevalence;high risk;Imprisonment;improved;Individual;informant;innovation;Internet;Intervention;Interview;Justice;Long-Term Care;men;Mental Health;mobile application;mortality risk;Outcome;outpatient programs;Outpatients;outreach;parole;parolee;Participant;Patient Self-Report;Phase;physical conditioning;Population;premature;primary outcome;probation;probationer;Process;programs;prototype;Public Health;Randomized;Randomized, Controlled Trials;rearrest;Recovery;Recovery Support;reduced substance use;Regulatory Pathway;Relapse;relapse risk;Research Personnel;Risk;Risk Behaviors;Sampling;satisfaction;Schedule;Screening Result;secondary outcome;Self Management;Services;Site;societal costs;substance use;Substance Use Disorder;substance use treatment;Supervision;Support System;support tools;Systems Integration;Technology;technology intervention;Theoretical model;theories;therapy design;tool;Transportation;treatment as usual;Treatment outcome;Urine;usability;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Continuing Care App for Justice-Involved Individuals with Substance Use Disorders