NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Depression;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention;Social Determinants of Health;Suicide

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: PROJECT NARRATIVE Peer victimization is a common and potent predictor of psychopathology in adolescence, but the behavioral and neural mechanisms underlying this association remain unknown. I will test a novel conceptual model assessing how dimensions of peer victimization—peer threat and peer deprivation—differentially shape neurocognitive processes and social behaviors that confer risk for internalizing psychopathology. Identifying developmental processes that are disrupted following peer victimization and ultimately lead to psychopathology is a necessary first step in developing targeted intervention approaches to mitigate the effects of peer victimization on youths.

PI_NAMEs: RODMAN, ALEXANDRA MAYORCA (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Adolescence;Adolescent;Adult;Affect;Amygdaloid structure;Anterior;Anxiety;Award;Behavior;Behavior assessment;behavior influence;Behavioral;Behavioral Mechanisms;biological adaptation to stress;career;Clinical Sciences;Cognitive;Communication;Complex;computational neuroscience;Computer Models;Corpus striatum structure;Data;deprivation;Detection;Development;Developmental Process;digital phenotyping;Dimensions;Disease;Dorsal;Early Intervention;Ecological momentary assessment;Emotional;Evaluation;experience;experimental study;Exposure to;Functional Magnetic Resonance Imaging;handheld mobile device;information processing;innovation;Insula of Reil;Intervention;Laboratories;Left;Life;life span;Link;Location;longitudinal design;Machine Learning;machine learning method;media use;Mediating;Mental Depression;mobile computing;Modeling;Monitor;Motivation;negative affect;neural;Neurocognitive;neuromechanism;novel;novel strategies;Pathway interactions;Pattern;peer;peer victimization;Phase;Physical activity;Physiological;Play;positive emotional state;predictive modeling;prevent;Process;prospective;Psychopathology;psychosocial;Recurrence;Reporting;Research;Research Personnel;response;reward processing;Rewards;Risk;Risk Factors;Role;Shapes;skills;social;Social Behavior;social communication;social engagement;social exclusion;social media;social neuroscience;statistical and machine learning;suicidal;suicidal behavior;Suicide;Symptoms;Techniques;Telephone;Testing;Time;tool;Training;two-dimensional;Victimization;Youth

PROJECT_TITLE: Behavioral and neurocognitive mechanisms linking peer victimization to adolescent psychopathology

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PI_NAMEs: LOPEZ-RAMIREZ, MIGUEL ALEJANDRO (contact)

PROGRAM_OFFICER_NAME: KINDZELSKI, ANDREI L

PROJECT_TERMS: activated Protein C;activated protein C receptor;Actomyosin;Adhesions;Adult;Affect;Animal Model;antagonist;Anti-Inflammatory Agents;Anticoagulants;Aorta;Atherosclerosis;base;Binding;Blood flow;Blood Vessels;Cardiovascular Diseases;CCM1 gene;Cell Adhesion Molecules;Cell Physiology;Cells;cerebral cavernous malformations;cofactor;Collaborations;Complex;Cultured Cells;cytokine;Data;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Gene Expression;Generations;Genes;Genetic;GKLF protein;Health;Heart;hemodynamics;Hemostatic function;Homeostasis;in vivo;Inflammation;insight;Intercellular Junctions;Knock-out;Knowledge;Leukocytes;Mediating;Modeling;Mus;NOS3 gene;novel;Outcome;Perinatal;pharmacologic;Physiology;platelet function;Platelet Inhibitors;prevent;Property;Protein C;protein complex;protein expression;Proteins;Regulation;response;small molecule;small molecule inhibitor;Structure;Study models;Testing;Therapeutic;Thrombomodulin;Thrombosis;thrombotic;TNFSF5 gene;transcription factor;Up-Regulation;vascular bed;Vascular Endothelial Cell;vascular inflammation

PROJECT_TITLE: Genetic and pharmacological manipulation of HEG1-KRIT1 protein complex modulates endothelial vasoprotective functions

STUDY_SECTION: HLBP

STUDY_SECTION_NAME: Heart, Lung, and Blood Program Project Study Section[HLBP]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: This proposal for a Biomarker Characterization Center seeks to improve upon the management of lung cancer and other malignancies through detection of tumor specific abnormal DNA methylation in plasma. The Biomarker Development Lab will discover new loci with a high prevalence of cancer specific methylation in lung cancer and others, and develop new and more sensitive methods of detection. These approaches will be transferred to the Biomarker Reference Lab for testing in a clinical setting, and operations of these two components and their communication facilitated by the Administrative Core.

PI_NAMEs: CHRISTENSON, ROBERT H.;HERMAN, JAMES G. (contact);WANG, TZA-HUEI JEFF

PROGRAM_OFFICER_NAME: WANG, WENDY

PROJECT_TERMS: Address;Age;Apoptotic;Benign;Bioinformatics;Biological;Biological Assay;Biological Markers;biomarker development;bisulfite;Blood;Cancer Detection;Cancer Diagnostics;Cancer Etiology;Categories;cell free DNA;Cessation of life;circulating DNA;Classification;Clinical;Clinical Pathology;clinical practice;cohort;Communication;Complement;computed tomography screening;cost;Data;Detection;detection assay;detection method;detection platform;Diagnosis;Diagnostic Procedure;Diameter;DNA;DNA analysis;DNA Markers;DNA Methylation;DNA Sequence;Dreams;Early Detection Research Network;Early Diagnosis;Event;Frequencies;Funding;Genes;Goals;Healthcare;High Prevalence;Histology;Human;Hypermethylation;improved;Laboratories;laboratory development;Lung;lung cancer screening;Lung Neoplasms;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Methylation;methylation biomarker;Molecular;mortality;Necrosis;neoplastic cell;Nodule;novel;novel strategies;Nucleic Acids;operation;Organ;Participant;Patients;Performance;Plasma;Population;Preparation;Process;prospective;Prospective cohort;Protocols documentation;Radiology Specialty;Reagent;Reporting;Reproducibility;Research Personnel;Risk;Sampling;screening;Screening for cancer;Sensitivity and Specificity;Signal Transduction;Site;Source;Specimen;Standardization;Testing;The Cancer Genome Atlas;Time;tumor;tumor DNA;United States;wasting;Work

PROJECT_TITLE: Optimizing Ultrasensitive DNA methylation detection for lung cancer and other malignancies


NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This project is designed to achieve two major objectives: 1) determine the frequency of different types of heart attacks (type 1-5) in the Multi-Ethnic Study of Atherosclerosis (MESA) over 14 years of follow-up, and 2) identify risk factors specific for the different types of heart attacks. Understanding the specific risk factors that cause the different types of heart attacks will enable scientists to identify who is at risk of which specific type of heart attack, and develop treatments specific to these different types of heart attacks (i.e., precision medicine). This will allow physicians to tailor treatments to individual patients' risk that will maximize benefit, minimize risks and more efficiently utilizing healthcare resources.

PI_NAMEs: DEFILIPPIS, ANDREW  (contact);NASIR, KHURRAM

PROGRAM_OFFICER_NAME: JAQUISH, CASHELL E

PROJECT_TERMS: Accounting;Acute;Acute myocardial infarction;adjudication;Ancillary Study;Atherosclerosis;Brain natriuretic peptide;calcification;Calcium;cardiovascular risk factor;Cardiovascular system;Categories;Cause of Death;Characteristics;Cholesterol;Classification;Clinical;clinical risk;cohort;Collection;Communities;Consensus;coronary artery calcium;coronary plaque;Coronary Thrombosis;Data;density;design;Development;Epidemiology;Equation;Etiology;Evaluation;Event;experience;Factor Analysis;falls;follow-up;Frequencies;Funding;Future;Gender;health care service utilization;Hypertension;Incidence;Individual;individual patient;individualized medicine;innovation;International;Ischemia;Knowledge;LDL Cholesterol Lipoproteins;Letters;Lipoprotein (a);Measures;Medical Records;Modernization;Multi-Ethnic Study of Atherosclerosis;Myocardial;myocardial damage;Myocardial Infarction;myocardial injury;Myocardial Ischemia;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Outcome;Oxygen;Participant;Patient risk;Patients;Phenotype;Physicians;Population;precision medicine;Predisposing Factor;Prevalence;Prevention;Prevention strategy;Process;Prognosis;Prospective cohort;Reporter;Resources;Risk;Risk Factors;risk minimization;risk prediction;Sampling;Scientist;Secondary to;Standardization;thrombogenesis;thrombotic;Time;tool;Troponin

PROJECT_TITLE: Contemporary Classification of Myocardial Injury Events in MESA: Defining Distinct Risk Factor Associations with Myocardial Infarction Type 1-5 and Acute Non-Ischemic Myocardial Injury

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Lung;Lung Cancer;Prevention

PI_NAMEs: HERMAN, JAMES G. (contact)

PROJECT_TERMS: Biological Markers;biomarker development;biomarker validation;Blood;Budgets;Clinical;Communication;Complex;Comprehensive Cancer Center;Detection;Development;DNA Methylation;Early Detection Research Network;Funding;Goals;Individual;innovative technologies;Institution;Laboratories;laboratory development;Malignant neoplasm of lung;Malignant Neoplasms;Maryland;material transfer agreement;meetings;methylation biomarker;multidisciplinary;Pennsylvania;Preparation;programs;Progress Reports;research clinical testing;Research Personnel;Resources;Sampling;Schedule;Screening for cancer;Site;Site Visit;Testing;Travel;Universities;Validation

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Prevention

PROJECT_TERMS: Anatomy;Apoptotic;Benign;Biological;Biological Markers;biomarker development;bisulfite;Blood;Body Fluids;Breast;cancer biomarkers;Cancer Detection;Cancer Etiology;cancer type;Categories;circulating DNA;Classification;Clinical;clinical implementation;Collection;Colorectal;computed tomography screening;cost effective;Data;design;Detection;detection assay;detection method;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Diameter;digital;DNA;DNA Methylation;Early Detection Research Network;Early Diagnosis;Epigenetic Process;Event;Funding;Genetic;Head and neck structure;Healthcare;High Prevalence;Histology;improved;Laboratories;laboratory development;Location;low dose computed tomography;Low Prevalence;Lung;lung cancer screening;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Methods;Methylation;methylation biomarker;Molecular;Monitor;mortality;multidisciplinary;Necrosis;neoplastic cell;Nodule;novel;Nucleic Acids;Pancreas;Participant;Patients;Performance;performance tests;Plasma;Process;prospective;Prostate;Reporting;Research Design;Research Personnel;Sampling;screening;Screening for cancer;Sensitivity and Specificity;Source;Specimen;Standardization;Testing;The Cancer Genome Atlas;Tissues;tumor;tumor DNA;tumorigenesis;United States;Validation;wasting

PROJECT_TITLE: Core - Biomarker Development Laboratory (BDL)


PROJECT_TERMS: Address;arm;assay development;Baltimore;Benign;Biological Assay;Biological Markers;biomarker development;biomarker validation;Biopsy;Blinded;Body Fluids;Cancer Etiology;candidate marker;Categories;Cells;Cessation of life;Characteristics;CLIA certified;Clinical;Collaborations;Detection;Development;Diagnostic Procedure;Diameter;Disease;DNA Methylation;Early Detection Research Network;Early Diagnosis;Ensure;Evaluation;Exhibits;experience;flexibility;Funding;Healthcare;Image;Knowledge;Laboratories;laboratory development;Lesion;liquid biopsy;Longterm Follow-up;Lung;lung cancer screening;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Maryland;Methodology;Methods;Methylation;methylation biomarker;Morbidity - disease rate;mortality;multidisciplinary;Nodule;Operative Surgical Procedures;Participant;Patients;Performance;Plasma;Population;Predictive Value;Procedures;prospective;Quality Control;Reagent;Reproducibility;Research Personnel;sample collection;Sampling;screening;Screening Result;Specificity;Standardization;Technology;Testing;Time;Universities;Validation;wasting

PROJECT_TITLE: Core - Biomarker Reference Laboratory (BRL)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Genetics

ORG_CITY: ATLANTA

ORG_NAME: AMERICAN COLLEGE OF RHEUMATOLOGY

ORG_STATE: GA

PHR: Project Narrative The goals of the five-year grant will be to foster understanding of disease and development of new therapies for patients with rheumatic diseases, this conference seeks to (1) assemble rheumatology clinicians and researchers in a scientific forum to discuss advances in the disease (2) strategize on research related to new treatments of rheumatic diseases and (3) foster underrepresented minorities, young investigators and fellows- in-training in the research exposure.

PI_NAMEs: HIRAKI, LINDA T. (contact)

PROGRAM_OFFICER_NAME: MANCINI, MARIE

PROJECT_TERMS: Advocacy;Affect;American;Arthritis;Basic Science;Biology;Characteristics;chronic pain;Clinical;clinical practice;Clinical Research;Clinical Services;college;Colorado;Communities;cost;COVID-19;Degenerative polyarthritis;Department chair;Development;Discipline;Disease;Education;Epidemiology;Event;Evolution;Fostering;Genetic;genetic epidemiology;Genome;Goals;Grant;Head;Health;Health Services Research;Healthcare;Human;Immunology;Immunotherapeutic agent;improved;insight;interest;Investigation;Israel;Knowledge;Laboratories;Medical;Medical center;Medical Research;Medicine;meetings;mid-career faculty;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel therapeutics;Oral;Pain;Participant;Patient Care;Patients;Persons;Physiology;Practice Management;professor;programs;Public Health;Public Health Schools;Research;Research Institute;Research Personnel;Research Training;Resources;Rheumatism;Rheumatology;Role;Schedule;Scientist;Somatic Mutation;Spondylarthritis;symposium;Time;Training;Translating;Translational Research;Underrepresented Minority;United States National Institutes of Health;Universities;virtual

PROJECT_TITLE: ACR Basic & Clinical Research Conference:  Disrupting the Genetics of Rheumatology:  The Role of Somatic Mutations in Health and Disease

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: There have been no new FDA-approved drugs for Alzheimer’s disease in more than 20 years. The goal of this project is to develop artificial intelligence (AI) approaches for extracting unforeseen patterns from clinical, genetic, genomic, and imaging data that could lead to ideas for new drug development. Our proposed AI methods and software will be open-source, user-friendly, and freely available for all to use.

PI_NAMEs: MOORE, JASON H. (contact);RITCHIE, MARYLYN D;SHEN, LI

PROGRAM_OFFICER_NAME: YAO, ALISON Q

PROJECT_TERMS: Affect;Algorithms;Alzheimer's Disease;Alzheimer’s disease biomarker;American;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence method;biobank;Biochemical Pathway;Biological;Biological Markers;Biomedical Computing;biomedical informatics;Brain imaging;Clinical;clinical decision support;Collection;Computer software;cost;Data;Data Analyses;Data Sources;Dimensions;Disease;drug development;Ensure;FDA approved;feature selection;Genetic;Genomics;Goals;Heart;Image;Informatics;innovation;Investments;Joints;Knowledge;large scale data;Learning;Machine Learning;machine learning algorithm;machine learning model;Methods;Modeling;multimodality;multiple omics;novel;novel therapeutics;open source;Pattern;Pharmaceutical Preparations;Population Study;programs;protein aggregation;protein misfolding;Public Health Informatics;Reproducibility;Research;Research Project Grants;Source;Structure;Technology;user-friendly

PROJECT_TITLE: Artificial Intelligence Strategies for Alzheimer's Disease Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-D(03)]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LOWELL

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: Project Narrative Finding previously uncharacterized effects of common drugs on cancer or Alzheimer's disease has the potential to immediately impact clinical care. These discoveries can both prevent some cases of disease, and point to new treatments. Instead of requiring thousands of experiments, we will find these effects systematically and efficiently by creating new methods for analysis of existing data.

PI_NAMEs: MELAMED, RACHEL DANIA (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: Alzheimer's Disease;Alzheimer's disease model;American;clinical care;Clinical Management;Data;Data Sources;Dementia;Disease;disorder prevention;drug repurposing;Drug Side Effects;Etiology;Evaluation;experimental study;Future;Genetic;Health;health data;health record;improved;innovation;Late-Onset Disorder;Malignant Neoplasms;Methods;middle age;Mining;Neurodegenerative Disorders;novel;Outcome;Pathologic Processes;Persons;Pharmaceutical Preparations;prevent;Risk;side effect;Testing;Work

PROJECT_TITLE: Integrating genetics and health data to discover common drug effects on cancer and Alzheimer's disease

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Obesity has become a major public health concern as it increases the risk for type 2 diabetes, heart attack, certain forms of cancer, hypertension and stroke. Obesity results from the interaction between the environment and genetic predisposition. This research proposal is aimed at understanding better how mutations in the Melanocortin-4 receptor, a brain expressed gene that controls food intake in response to peripheral cues, cause severe obesity in humans. This research could lead to a better understanding on how people become obese and could lead to new treatments for this condition.

PI_NAMEs: VAISSE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: PAWLIKOWSKA, LUDMILA SYLWIA

PROJECT_TERMS: Adult;Alleles;Body Weight;Brain;Brain region;cancer type;Cause of Death;Cellular biology;Central Nervous System;Cilia;Code;Coupled;Cues;Data;Defect;Dietary intake;Disease;Eating;Environment;Eukaryotic Cell;Family Study;Fasting;Fatty acid glycerol esters;feeding;Food Intake Regulation;Funding;G-Protein-Coupled Receptors;Gene Mutation;Genes;Genetic;Genetic Predisposition to Disease;Genotype;GTP-Binding Proteins;Heritability;Heterozygote;Homeostasis;Human;Hypertension;Imaging Device;Impairment;in vivo;Individual;insight;Investigation;Laboratories;Length;Ligands;Link;Malignant Neoplasms;Measures;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;Molecular;Morbid Obesity;mouse model;Mutation;mutation carrier;Myocardial Infarction;Neurons;neurotransmission;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity in children;obesity treatment;Organelles;Pathogenicity;Pathologic;Pattern;Penetrance;Peripheral;Persons;Phenotype;Physiological;Population;Prevalence Study;Public Health;receptor;Regulation;Reporting;Research;Research Project Grants;Research Proposals;response;Risk;Role;Signal Transduction;Stroke;Testing;tool;Twin Studies;Variant

PROJECT_TITLE: The Melanocortin-4 Receptor in Human Obesity

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Gene Therapy;Genetics;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE TDP-43 aggregation is a hallmark of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), an Alzheimer's Disease Related Dementia (ADRD). I aim to understand how interactions of TDP-43 with RNA contribute to disease etiology and how RNA can rescue TDP-43 aggregation and disease phenotypes. Successful completion of my proposal will result in the development of a therapeutic that can be advanced for treatment of patients with ALS and FTD.

PI_NAMEs: COPLEY, KATIE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Affect;ALS patients;Alzheimer's disease related dementia;Amyotrophic Lateral Sclerosis;Behavior;Binding;Biochemical;Biological Assay;C-terminal;career;Cell model;Cells;cellular pathology;Cessation of life;Clinical;collaborative environment;crosslinking and immunoprecipitation sequencing;Cytoplasm;Data;Data Analyses;design;Development;Disease;disease phenotype;disorder subtype;Electron Microscopy;Environment;Etiology;Evolution;Exhibits;experimental study;Fibroblasts;Fostering;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;gain of function;Goals;Health;In Vitro;in vitro Assay;insight;Laboratories;Language;Link;loss of function;Missense Mutation;Modeling;Molecular;motor impairment;Motor Neurons;mutant;Nerve Degeneration;Neurodegenerative Disorders;neuron loss;Neurons;Neurosciences;Nucleotides;Pathologic;Pathology;Patients;Pennsylvania;Personality;Physiology;prevent;protein TDP-43;Recombinants;Research Personnel;RNA;RNA Binding;RNA Splicing;RNA-Binding Proteins;Role;Solubility;Specificity;stem;success;Symptoms;TDP-43 aggregation;Techniques;Temporal Lobe;Testing;Therapeutic;therapeutic RNA;therapeutically effective;Toxic effect;Training;transcriptome sequencing;Universities;Variant

PROJECT_TITLE: Developing RNA therapeutics for TDP-43 proteinopathy in ALS/FTD


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: UNIVERSITY OF MASSACHUSETTS BOSTON

PHR: NARRATIVE Germline or somatic mutation in BRCA2 (B2) confers exceptionally high risk for breast, ovarian and prostate cancer. Work proposed in this grant application aims to identify novel means to target BRCA2 mutant cancer and also find new biomarkers of BRCA2 pathogenicity.

PI_NAMEs: PATHANIA, SHAILJA  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Address;Affect;Applications Grants;Automobile Driving;Biological Markers;BRCA2 gene;BRCA2 Mutation;Breast Cancer Risk Factor;cancer prevention;Cells;Chemoresistance;chemotherapy;Classification;Climacteric;Combination Drug Therapy;Cytosine;Cytosine deaminase;Data;Deaminase;Deamination;Defect;design;DNA;DNA Damage;DNA replication fork;DNA Sequence Alteration;DNA-(apurinic or apyrimidinic site) lyase;Down-Regulation;Drug Combinations;efficacy evaluation;Enzymes;Event;exhaustion;experimental study;Family;Genome;Genome Stability;Genomic Instability;genomic locus;Germ-Line Mutation;Goals;Heterozygote;high risk;Incidence;Individual;insight;Knowledge;Lead;Learning;lifetime risk;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Gland Parenchyma;Molecular;mutant;mutation carrier;neoplastic cell;Normal Cell;novel;novel therapeutic intervention;Nucleotide Excision Repair;Operative Surgical Procedures;Ovarian Tissue;Pancreas;Pathogenicity;Pathway interactions;Patients;potential biomarker;Predisposition;Prevention strategy;Process;prophylactic;Prostate;Publishing;repaired;replication factor A;replication stress;Risk;Role;Single-Stranded DNA;Site;Somatic Mutation;Source;Testing;Therapeutic;Time;Tissues;tool;Treatment Efficacy;tumor;tumorigenesis;Uracil;variant of unknown significance;Woman;Work;Xenograft Model

PROJECT_TITLE: Mechanisms Underlying Replication Stress And Genome Instability Upon BRCA2 Deficiency

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ORG_CITY: WEST LAFAYETTE

ORG_DEPT: CHEMISTRY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE Manmade nanocages to mimic protein cavities can be useful for medical research, as they can recognize important biological targets for sensing and catalyze reactions to synthesize therapeutics. This work proposes to create some of the first fully sequenced-defined nanocages with protein-mimetic, robust cavities, thus providing new solutions in fields of sensing and catalysis. Ultimately, this work will lead to selective, rapid sensing devices for neuropeptides to help elucidate the etiology of a variety of brain disorders, as well as to new artificial enzymes useful to synthesize otherwise difficult to access therapeutic agents.

PI_NAMEs: SCHNEEBELI, SEVERIN THOMAS (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Robust Sequence-defined Nanocages with Protein-mimetic Cavities


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Rare Diseases;Sickle Cell Disease;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE There is a science-to-practice gap in sickle cell disease (SCD) between evidence-based guidelines and the care that is delivered. Issues are worsened for individuals living in rural regions or with socio-economic challenges known to accentuate health disparities. The current project, Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) will advance efforts to identify and link unaffiliated patients to SCD specialists by applying implementation science research to adapt existing methods used in human immunodeficiency virus (HIV) care.

PI_NAMEs: HSU, LEWIS LI-YEN;JACOBS, SARA RUBIN;KANTER, JULIE  (contact);TREADWELL, MARSHA J

PROGRAM_OFFICER_NAME: HAILU, BENYAM

PROJECT_TERMS: Address;Adult;Affect;Area;barrier to care;Caring;Clinic;Clinical;Clinical Services;Comprehensive Health Care;Consensus;Consultations;cost;Country;Data;Disease;Dissemination and Implementation;Ensure;Evaluation;evidence base;evidence based guidelines;experience;Funding;Future;Goals;Guidelines;health disparity;Health system;Healthcare;HIV;implementation science;implementation strategy;improved;Individual;Interactive Systems Framework;Knowledge;Learning;Link;Mentors;Methods;Modeling;National Heart, Lung, and Blood Institute;organizational readiness;Pathway interactions;patient engagement;patient oriented;Patients;Population;Preventive service;primary care provider;Process;process evaluation;Program Effectiveness;programs;Protocols documentation;Provider;Readiness;recruit;Research;Research Methodology;Research Personnel;rural area;Science;screening;service gap;Sickle Cell Anemia;Site;social stigma;socioeconomics;Specialist;success;System;Testing;Training;Underserved Population;Work

PROJECT_TITLE: Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell disease

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: In this application, we propose a Core Center for Clinical Research (CCCR) at Northwestern University to promote cutting-edge clinical research aimed at prevention or control of rheumatic and musculoskeletal conditions and poor outcomes associated with them. While we will provide broad support, we will particularly seek to drive this theme: prevention strategy and intervention development through lifestyle, behavioral, medical, and rehabilitative solutions, built on a foundation of person-centered assessment in daily life and community engagement. Because our CCCR is centered on the goal to improve how persons feel and function in their daily lives, focuses on community and personal experience, and builds upon the wearable and portable technology revolution, we are positioned to have substantial impact on work within and beyond our institution.

PI_NAMEs: SHARMA, LEENA  (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Abbreviations;Acceleration;Accelerometer;Area;Attention;Behavioral;Behavioral Sciences;Bioinformatics;Budgets;Clinical;clinical center;clinical development;Clinical Informatics;Clinical Research;cognitive function;cohort;Collaborations;Communication;Communities;community advisory board;community engaged research;community engagement;Community Outreach;Consult;cost effectiveness;Data;data management;data sharing;data streams;Database Management Systems;Databases;design;Development;Disease;economic evaluation;education research;Educational Activities;empowerment;Ensure;Environment;Epidemiology;Equity;Evaluation;experience;Feedback;Fostering;Foundations;Funding;Genomics;Goals;Grant;handheld mobile device;Health;health equity;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Lead;Leadership;Life;Life Style;Manuscripts;Medical;member;Mental Health;Methodology;Mission;Motor;Musculoskeletal;Neighborhoods;Nutritional Science;operation;Operations Research;Outcome;Outcome Assessment;Outcome Measure;Pathway interactions;Patient Self-Report;Performance;performance based measurement;person centered;personalized approach;Persons;Physical activity;Physical assessment;Physiological;Policy Analysis;portability;Positioning Attribute;pragmatic study;Prevention;Prevention strategy;preventive intervention;Procedures;Productivity;programs;prospective;psychologic;Recommendation;Registries;Rehabilitation therapy;Research;Research Design;Research Personnel;Resource Sharing;Resources;Risk;satisfaction;Science;Scientist;sedentary lifestyle;sensor;Sensory;Sleep;social;social health determinants;Specialist;Statistical Data Interpretation;Structure;Symptoms;synergism;technological innovation;Technology;therapy development;Training;Universities;Vision;wearable device;wearable sensor technology;web based interface;Work

PROJECT_TITLE: Core Center for Clinical Research at Northwestern University


ADMINISTERING_IC: HD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SANTA BARBARA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CALIFORNIA SANTA BARBARA

PHR: Project Narrative Recent advances in models for studying human gastrulation present the opportunity to answer questions in the field of early human embryology that have been unanswered for decades. This proposal will thoroughly investigate the role of the intracellular signaling pathway MAPK/Erk signaling dynamics in human gastrulation through a combination of micron-scale stem cell engineering technologies and optogenetic tools, that enable the systematic variation of signaling patterns. This work will increase understanding of signaling mechanisms that drive pattern formation in the human gastruloid and investigate how RASopathies effect human gastrulation.

PI_NAMEs: BAXTER, NAOMI JESSIE (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Address;Animals;Biological;BMP4;cell behavior;Cell Line;Cell Physiology;Cell Proliferation;cell type;Cells;Characteristics;Complex;CRISPR/Cas technology;Cues;Defect;Development;developmental disease;Ectoderm;Embryo Research;Embryology;engineered stem cells;Engineering;Ethics;Etiology;Exhibits;experimental study;Fibroblast Growth Factor;gastrulation;Gene Expression Profile;Genes;genome editing;Germ Layers;Homeostasis;Human;Human Development;human embryonic development;human embryonic stem cell;human model;Image;insight;Knowledge;Lead;Light;Link;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Measures;Mesoderm;migration;model organism;Modeling;Molecular;Mutation;optogenetics;Outcome;Pathway interactions;Pattern;Pattern Formation;Phosphotransferases;Play;Positioning Attribute;Process;Reporter;Reproducibility;Role;Signal Pathway;Signal Transduction;small molecule inhibitor;spatiotemporal;Stains;stem cell fate;stem cells;Study models;System;Technology;Therapeutic Intervention;Time;tool;transmission process;Variant;Visualization;Work

PROJECT_TITLE: Dissecting the role of Erk signaling dynamics in positioning and coordinating germ layer fates

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Networking and Information Technology R&D (NITRD);Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: LEE, JUNGWHA JULIA (contact)

PROJECT_TERMS: Acceleration;Accelerometer;Address;advanced analytics;Area;Attention;Behavioral;Behavioral Sciences;Bioinformatics;Clinical;clinical center;clinical implementation;Clinical Informatics;Clinical Research;cohort;Collaborations;Communities;community advisory board;community engagement;Consultations;COVID-19;COVID-19 impact;COVID-19 pandemic;Creativeness;Data;Data Analyses;Data Collection;data management;data streams;data warehouse;Database Management Systems;Databases;design;Development;Development Plans;Disease;economic evaluation;Educational Activities;electronic data;Electronic Health Record;Elements;Environment;Epidemiology;Event;experience;Faculty;Fostering;Foundations;Genomics;Grant;handheld mobile device;improved;Individual;Informed Consent;Infrastructure;innovation;Institution;Intervention;Lead;Learning;Life;Life Style;Manuscripts;Medical;Medicine;Mental Health;Mentors;Methodology;Mission;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neighborhoods;next generation;Nutritional Science;Outcome;Outcome Measure;pandemic disease;Patient Outcomes Assessments;Patient Self-Report;Patients;Performance;performance based measurement;person centered;personalized approach;Physical activity;Physical assessment;physical conditioning;Physical Function;Physiological;Policy Analysis;pragmatic study;Prevention strategy;preventive intervention;Productivity;psychologic;public health research;Recommendation;recruit;Registries;Rehabilitation therapy;repository;Reproducibility;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;Research Support;resilience;Resources;response;Rheumatism;Safety;satisfaction;sedentary lifestyle;sensor;Services;Sleep;social health determinants;Social outcome;Specialist;stakeholder perspectives;Statistical Data Interpretation;therapy development;Training;translational scientist;Universities;virtual;Visit;Vulnerable Populations;wearable sensor technology;web based interface;Work

PROJECT_TITLE: Methodologic Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Chronic Pain;Clinical Research;Data Science;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pain Research;Pediatric;Precision Medicine;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Public Health Relevance: Approximately 3.5 million adolescents suffer from high impact chronic musculoskeletal (MSK) pain. Current treatments for chronic MSK pain are suboptimal with a recovery rate of ~50%. Discovery and validation of a prognostic and robust signature for pain recovery vs. persistence will facilitate risk stratification, a more resourceful selection of patients who are likely to respond for undergoing current multidisciplinary pain treatment approaches, and new insight into biological and behavioral processes that may be exploited to develop novel strategies profiting those who are refractory.

PI_NAMEs: SIMONS, LAURA E (contact)

PROGRAM_OFFICER_NAME: ARUDCHANDRAN, RAMACHANDRAN NMN

PROJECT_TERMS: Adolescence;Adolescent;adolescent patient;Adult;Affect;Algorithms;analysis pipeline;Behavioral;Big Data;biobank;Biological;biomarker discovery;biomarker signature;biopsychosocial;biosignature;Brain;Canada;Central Nervous System;Child;Childhood;Chronic;chronic musculoskeletal pain;chronic pain;Classification;Clinical;Clinical Trials;clinically actionable;cohort;complex data;Computer Analysis;Data;Data Set;Development;Dimensions;disability;Economic Burden;Enrollment;Equipment and supply inventories;experience;Family;functional disability;Funding;Helping to End Addiction Long-term;high risk population;Hospitals;Image;Immune;Individual;individualized medicine;insight;Intervention;Life;Machine Learning;machine learning algorithm;Marker Discovery;Measurement;Measures;Medical center;medical schools;Mental Depression;Modeling;Moods;multidisciplinary;Musculoskeletal;neuroimaging;Neurons;new therapeutic target;novel;novel strategies;opioid epidemic;Pain;pain catastrophizing;Pain Clinics;Pain intensity;Pain management;Patient Selection;Patients;Pediatric Hospitals;Phase;Phenotype;Policies;Population;Positioning Attribute;Predictive Value;Prevention;Process;prognostic;Prognostic Marker;prognostic signature;prognostic value;psychologic;Psychological Factors;public health relevance;Quality of life;Recovery;Refractory;Reporting;Research Project Grants;response;risk stratification;sample collection;Sample Size;Sampling;Schools;Scientist;Sensory;Severities;skills;Standardization;Structure;System;Teenagers;Translational Research;treatment strategy;Universities;Validation;virtual

PROJECT_TITLE: SPRINT: Signature for Pain Recovery IN Teens


NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Prevention;Social Determinants of Health

PI_NAMEs: ROTHROCK, NAN E (contact)

PROJECT_TERMS: Accelerometer;Address;Attention;Awareness;Behavior Therapy;Behavioral;Budgets;Child Care;clinical center;Clinical Research;cognitive function;Collaborations;Communities;community advisory board;community engaged research;community engagement;Community Outreach;community-centered;deprivation;design;digital technology;Disparity;education research;Educational Activities;Employment;environmental enrichment for laboratory animals;Equity;evidence base;experience;Feedback;food insecurity;Fostering;Foundations;Goals;Health;health equity;Healthcare;Housing;implementation facilitation;implementation science;improved;Individual;innovation;Institution;Intervention;Knowledge;Life;Life Cycle Stages;Life Style;Long-Term Care for Elderly;Medical;meetings;Mental Health;Methodology;Methods;Mission;Modeling;Motor;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Neighborhood Health Center;neighborhood safety;Neighborhoods;Outcome;Pathway interactions;Patient Self-Report;Patients;performance based measurement;person centered;Persons;Pharmaceutical Preparations;Physical activity;Physical assessment;Physiological;Pilot Projects;portability;Positioning Attribute;Prevention;Prevention strategy;preventive intervention;Procedures;Process;programs;Protocols documentation;psychologic;Race;racial discrimination;Reader;Rehabilitation therapy;Research;Research Design;Research Personnel;residential segregation;Resources;Rheumatism;Risk;satisfaction;Science;sedentary lifestyle;sensor;Sensory;service delivery;Services;Sleep;social;social health determinants;Social Sciences;Symptoms;Technology;technology intervention;technology platform;therapy development;Training;translational pipeline;Universities;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Resource Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: Narrative Technology-based interventions hold promise to extend the availability of support for individuals managing mental health concerns, but their success requires keeping users engaged over time. This K01 proposal leverages machine learning to establish a messaging intervention that can automatically adapt communication styles to accommodate users’ individualized support needs and preferences and their fluctuations over time. If successful, this project will lead to a scalable intervention model that delivers engaging, personalized support while imposing low burden on users and the health system, and that could be broadly applied to address a wide variety of mental health conditions.

PI_NAMEs: KORNFIELD, RACHEL  (contact)

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: adaptive intervention;Address;Adult;Affect;Algorithms;Anxiety;automated intervention;Behavior;behavior change;Behavior Therapy;Behavioral;career;career development;Cellular Phone;Clinical;Clinical Sciences;Cognitive;Communication;Control Groups;cost;Data;Dedications;depressive symptoms;design;digital health;digital mental health;Dimensions;Ecological momentary assessment;Educational workshop;Effectiveness;Effectiveness of Interventions;effectiveness trial;Environment;evidence base;Feedback;Feeling suicidal;Funding;Goals;Growth;Health system;improved;Individual;Institution;Intervention;intervention refinement;Interview;Learning;learning algorithm;Machine Learning;Mediation;medical schools;meetings;Mental Depression;Mental Health;Mentors;Methodology;Modality;Modeling;Monitor;Morbidity - disease rate;mortality;Motivation;Outcome;Participant;preference;primary outcome;Procedures;Program Development;psychoeducation;Psychological reinforcement;Quality of life;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;recruit;Regulation;Research;response;Science;secondary outcome;Self Management;Severities;skill acquisition;Social Interaction;Social support;Societies;success;System;tailored messaging;Techniques;technology intervention;Testing;Text Messaging;therapy design;Time;tool;Training;treatment effect;Universities;usability;user centered design;Waiting Lists

PROJECT_TITLE: Adaptive Messaging to Support Depression Self-Management

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences;Pediatric

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: PROJECT NARRATIVE The goal of the current project is to combine two evidence-based treatments for school-aged children with ADHD: Central Executive Training (CET) and Behavioral Parent Training (BPT). CET is a computerized training intervention that improves ADHD symptoms and academic functioning by improving children’s working memory abilities. BPT is a therapeutic intervention that improves family functioning and child ODD symptoms by changing parenting behaviors. Their combined use is expected to provide complementary and additive benefits, particularly if CET is delivered before BPT.

PI_NAMEs: CHACKO, ANIL ;KOFLER, MICHAEL J (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: Academic achievement;acceptability and feasibility;actigraphy;active comparator;Address;Affect;Aftercare;Area;Attention deficit hyperactivity disorder;behavior measurement;Behavior Therapy;Behavioral;Behavioral Symptoms;Caregivers;Child;Child Behavior;Child Rearing;Childhood;Chronic;Clinical;Clinical Trials;Cognition;cognitive training;comorbidity;Complement;Complex;computerized;cost;design;Development;Disease;Educational Intervention;efficacious treatment;efficacy evaluation;efficacy trial;Evidence based treatment;Executive Dysfunction;Expectancy;experimental study;Family;Family member;follow-up;Game Theory;Goals;Guidelines;Human;Hyperactivity;Impairment;improved;Impulsivity;inattention;Individual;innovation;Intervention;intervention effect;Link;Longitudinal Studies;Maintenance;Manuals;Masks;Measures;Mediation;Memory impairment;Methods;Neurocognitive;next generation;Outcome;Parent-Child Relations;parenting intervention;Parents;Pattern;Pharmacological Treatment;Probability;Process;Productivity;Protocols documentation;Randomized;reduce symptoms;Reporting;Research;Risk Factors;Role;Schedule;School-Age Population;Short-Term Memory;success;Sum;Symptoms;teacher;Testing;Therapeutic Intervention;Training;treatment arm;Treatment Efficacy;Underachievement;Waiting Lists;Work

PROJECT_TITLE: Evaluating the Efficacy of Sequenced Central Executive and Behavioral Parent Training for Children with ADHD


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE This study will provide a comprehensive metabolomic landscape on the cell-type specific metabolomic changes during aging and the process of neurodegeneration when the brain is exposed to pathologic amyloid β and pathologic tau. This information will provide opportunities to develop new AD treatments targeting microglia and astrocytes. 2

PI_NAMEs: DAWSON, VALINA L. (contact);GLUNDE, KRISTINE ;KAM, TAE-IN ;NA, CHAN-HYUN

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: Affect;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease brain;Amyloid beta-Protein;Astrocytes;Autopsy;Brain;Brain Diseases;Brain region;brain tissue;cell type;Cells;Cerebellum;Cognitive deficits;Complement 1q;Complex;Consumption;CSF1R gene;Disease;Energy Metabolism;Exposure to;Genes;glial activation;Glucose;Glycolysis;Heterogeneity;Hippocampus;Human;human disease;in vivo;inhibitor;Injections;Injury;insight;Interleukin-1 alpha;Link;Lipids;mass spectrometric imaging;Mass Spectrum Analysis;Mediating;Metabolic;Metabolism;metabolome;metabolomics;Microglia;Monitor;Mus;Mutation;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neurons;neuroprotection;neurotoxic;neurotoxicity;novel;old mice;overexpression;Oxidative Phosphorylation;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pharmaceutical Preparations;Play;Population;prevent;Process;Production;Ramp;Reporting;Research;response;Rest;Role;saturated fat;Senile Plaques;System;tau Proteins;Therapeutic;TNF gene;Toxic effect

PROJECT_TITLE: Imaging Mass Spectrometry-Based Metabolomic Analysis of the Alzheimer's Brain


NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE RELEVANCE: Multiple myeloma (MM) is a common, incurable hematologic malignancy whose management is extremely costly, with long-established disparities disproportionally inflicting African American populations. However, MM lacks comparative modeling, like the six cancer sites within the CISNET, to guide its prevention and control policies. The proposed MM Incubator Program will develop such modeling to assess the value of guideline recommended therapies and novel intervention strategies for MM prevention and control across MM care continuum with the goals of reducing MM burden and disparities.

PI_NAMEs: CHANG, SU-HSIN  (contact);WANG, SHIYI

PROGRAM_OFFICER_NAME: ZHU, LI

PROJECT_TERMS: Adult;African American population;Area;Calibration;cancer care;Cancer Intervention and Surveillance Modeling Network;cancer site;caucasian American;Cessation of life;clinical practice;Clinical Trials;cohort;Colorectal Cancer;comparative;Continuity of Patient Care;cost;cost-effectiveness evaluation;Development;Diagnosis;Disease;disease natural history;Disparity;disparity reduction;Economic Burden;Evaluation;evidence base;flexibility;Goals;Guidelines;Health;health disparity;Hematologic Neoplasms;high risk;improved;Incidence;Incubators;innovation;Intervention;Life;Malignant Breast Neoplasm;Modeling;Monoclonal gammopathy of uncertain significance;Multiple Birth Offspring;Multiple Myeloma;Neoplasms;novel;novel strategies;Obesity;Patients;Pharmaceutical Preparations;Policies;population based;Precancerous Conditions;Precision therapeutics;premalignant;prevent;Prevention;Prevention strategy;process optimization;programs;progression risk;racial disparity;Recommendation;Regimen;Reporting;Research;Risk;Risk Management;Route;screening;Solid Neoplasm;survival outcome;survivorship;Treatment Protocols;trend;Universities;Washington

PROJECT_TITLE: Comparative modeling of multiple myeloma across myeloma control continuuum: prevention, treatment, and disparity reduction


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE This proposal will study elderly people living with human immunodeficiency virus (HIV) longitudinally over 3 years for cardiovascular health. Cardiometabolic diseases disproportionately develop in people living with HIV, and we are looking for new treatments to mitigate cardiometabolic disease and tools to predict the development of adverse cardiovascular health outcomes in blood samples. We will study participants’ blood cells immunometabolic changes longitudinally, proteins that make energy, and acquire longitudinal cardiovascular and whole body vascular imaging to advance our understanding of cardiovascular health in the HIV field.

PI_NAMEs: CORLEY, MICHAEL JAY (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Advanced Development;aerobic glycolysis;Age;age related;Age related comorbidities;Aging;Anti-Inflammatory Agents;antiretroviral therapy;Atherosclerosis;atherosclerotic plaque rupture;Automobile Driving;Biological;Biological Assay;Biological Markers;Blood Cells;Blood specimen;Blood Vessels;burden of illness;calcification;Calcium;Cardiac;Cardiology;Cardiometabolic Disease;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular health;cardiovascular imaging;Cardiovascular system;cell type;Cells;Clinical;cohort;Cohort Studies;Communicable Diseases;comorbidity;Coronary;Coronary Arteriosclerosis;Cryopreservation;Development;Diabetes Mellitus;Diagnosis;Early Diagnosis;effective therapy;Elderly;Enrollment;Enzymes;experience;fatty acid metabolism;follow-up;Functional disorder;Genes;Genetic Transcription;glucose uptake;Glycolysis;Goals;Heart failure;Heart Injuries;HIV;HIV disparities;HIV Infections;Hyperlipidemia;Hypertension;Image;Immune;immune activation;immune function;Individual;individual variation;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Insulin Resistance;Intervention;Ischemic Stroke;kidney dysfunction;lens;Life Style;Link;Longitudinal Studies;Measures;Mediating;Medicine;Metabolic;Metabolism;Methods;microbial;Mitochondria;monocyte;Morphologic artifacts;multidisciplinary;Myelogenous;Myeloid Cells;Myocardial Infarction;nonalcoholic steatohepatitis;novel;novel therapeutics;Older Population;Opportunistic Infections;Outcome;Oxidative Phosphorylation;Participant;Pathway interactions;Peripheral;Persons;Phosphorylation;Plasma;Population;Positioning Attribute;Prevalence;prevent;programs;Proteins;Radiology Specialty;Reporting;Research Design;Research Personnel;Resolution;Risk;Risk Factors;RNA;Smoking;Stress;Substance abuse problem;success;sudden cardiac death;Surface;syndemic;synergism;systemic inflammatory response;T-Lymphocyte;Therapeutically Targetable;Time;tool;vascular bed;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Investigating Cellular Immunometabolic Mechanisms Underlying HIV-Related Cardiovascular Disease Risk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-M(02)]


NIH_SPENDING_CATS: Aging;Osteoporosis;Pediatric

PHR: PROJECT NARRATIVE  Osteoporosis is the most common bone disorder in the world, affecting more than 10 million individuals in the US; however, treatment of osteoporosis, particularly among children remains ineffective. This project will determine the role of Plastin-3 in osteoblast differentiation and mineralization as it relates to the development of childhood-onset osteoporosis. This project will also establish a novel model system for the study of childhood- onset osteoporosis that will facilitate the identification of novel pathways and targets related to Plastin-3 and can be used in the development of alternative therapeutic strategies for osteoporosis.

PI_NAMEs: CHIN, SAMANTHA MEAGAN (contact)

PROGRAM_OFFICER_NAME: WINER, KAREN

PROJECT_TERMS: 2 year old;Actins;Adult;Affect;age-related disease;Alkaline Phosphatase;Biochemical;Biological Models;Biology;bone;Bone Density;Bone Development;Bone Diseases;bone fragility;bone health;bone loss;bone mass;Bone Resorption;bone turnover;Bundling;Calcium;Cellular biology;Child;Childhood;Clinical;Collagen Diseases;Cytoskeleton;Defect;Development;Diagnosis;Disease;early onset;effective therapy;Elderly;experimental study;F-Actin;Fishes;Fracture;Functional disorder;Future;Genes;genetic analysis;Genetic study;Goals;In Vitro;in vivo;in vivo Model;Individual;insight;Institution;knock-down;Knock-in;Life;Link;Mediating;Medical;Mentorship;mineralization;Modeling;Molecular;multidisciplinary;Mus;Musculoskeletal;mutant;Mutation;new therapeutic target;novel;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Osteogenesis;osteogenic;Osteoporosis;Osteoporotic;Pathogenicity;Pathway interactions;Patients;Physicians;Physiologic calcification;Physiological;plastin;Process;Proteins;Recording of previous events;Recurrence;Regulation;Research;Research Personnel;response;Role;Scientist;side effect;skills;Structure;Techniques;Testing;Therapeutic;therapeutic target;Time;Training;Training Programs;transcriptome sequencing;Transgenic Organisms;treatment response;Undifferentiated;Universities;Washington;Zebrafish

PROJECT_TITLE: Determining the Role of Plastin-3 in Osteoblast Differentiation and Mineralization


NIH_SPENDING_CATS: Genetics

PHR: PROJECT NARRATIVE Cytoplasmic La-related proteins (LARPs) are involved in post-transcriptional gene control by regulating the delicate balance between active translation, degradation, and storage of mRNAs. We seek to understand the intricacies of their “non-canonical” RNA recognition at a molecular level to illuminate how structural commonality and individuality contribute to their unique functionality. The results of this work will provide fundamental information on how various LARPs adopted to specific RNA targets as well as provide the molecular level framework for the design of novel therapeutic approaches targeting associated fibroproliferative diseases and cancers.

PI_NAMEs: SILVERS, ROBERT  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Adopted;Affinity;Behavior;Binding;Biochemical;Biophysics;cancer cell;Cell Cycle;Collagen Type I;comparative;Coupling;Cytoplasm;Data;Defect;design;Disease;druggable target;Equilibrium;Exhibits;fascinate;functional plasticity;Genetic Transcription;Goals;Individual;Individuality;insight;Investigation;Knowledge;Lanthanum;Malignant Neoplasms;Maps;member;Messenger RNA;Molecular;NMR Spectroscopy;novel therapeutic intervention;Play;posttranscriptional;programs;Proliferating;Protein Family;Proteins;Research;RNA;RNA Binding;RNA-Protein Interaction;Role;solid state nuclear magnetic resonance;Specificity;stem;Symbiosis;therapeutic development;therapy development;Time;Tissues;Translations;Work

PROJECT_TITLE: Structural Co-evolution of the LARP Superfamily and its Role in Functional Plasticity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: LM

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Project Narrative (Public Health Relevance Statement) Most of the healthcare system developing their own predictive models based on their local data therefore there models can not be used by other organizations. We are offering to train a foundation model using de-identified electronic health records and claims data for more than 60 million patients. Such a model can improve the accuracy and the generalizability for any predictive model.

PI_NAMEs: BEKHET, LAILA RASMY GINDY (contact)

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Architecture;Attention;base;Chemicals;Clinical;Clinical Data;Code;cohort;comorbidity Index;COVID-19;COVID-19 patient;Data;Data Element;Data Protection;Data Sources;design;Development;diabetic patient;Diagnosis;Electronic Health Record;Engineering;Evaluation;Event;experience;flexibility;Fostering;Foundations;Goals;Health;Health Care Costs;Healthcare Systems;Heart failure;improved;Intake;Journals;Knowledge;knowledge integration;Learning;Long COVID;Malignant neoplasm of pancreas;Methodology;Methods;model building;Modeling;Molecular;Natural Language Processing;Patient risk;Patient-Focused Outcomes;Patients;Peer Review;Performance;Pharmaceutical Preparations;Policies;Population;pre-trained model;pre-trained transformer;Predictive Cancer Model;predictive modeling;Preparation;public health relevance;Recommendation;Recording of previous events;Research Personnel;Risk;shot learning;Source;Structure;structured data;symposium;Terminology;Time;Training;training data;Unified Medical Language System;Variant;Work

PROJECT_TITLE: Clinical foundation model for structured clinical data

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE While the Affordable Care Act-mandated Hospital Readmission Reduction Program launched in 2012 has modestly reduced readmissions, an unintended consequence has been the shift of a significant fraction of heart failure (HF)-related care to the outpatient setting. However, little is known about the epidemiology, clinical profile, treatment patterns, and/or outcomes of outpatient worsening HF (WHF). To address these critical knowledge gaps, we propose (1) to systematically describe the contemporary epidemiology, clinical characteristics, treatment patterns, and outcomes associated with outpatient WHF and (2) to evaluate the impact of an episode of outpatient WHF on generic and disease-specific HRQOL in the context of a fully integrated health care delivery system.

PI_NAMEs: AMBROSY, ANDREW PATRICK (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Acute;Address;adjudication;Affordable Care Act;Algorithms;analytical method;Award;Board Certification;California;Cardiac;Caring;Characteristics;Clinical;clinical encounter;clinical risk;Clinical Trials;cohort;Computer software;Congestive Heart Failure;Data;Data Sources;deep learning;design;Devices;Disease;EHR research;electronic health record system;Environment;Epidemiology;Event;evidence base;experience;Funding;Future;Goals;Guidelines;Health Policy;health related quality of life;Health Services;Health system;Heart failure;high risk;hospital readmission;Hospitalization;Hospitals;Impairment;implementation science;improved;Incentives;Incidence;innovation;Institution;Integrated Delivery of Health Care;interest;International;K-Series Research Career Programs;Knowledge;Learning;Location;Machine Learning;machine learning algorithm;Manuals;Medical;Mentors;Mentorship;Methodology;Morbidity - disease rate;mortality;Natural History;Natural Language Processing;novel;Outcome;Outpatients;Patient Admission;Patient Care;Patients;Pharmaceutical Preparations;Physicians;Pragmatic clinical trial;programs;prospective;Public Health;readmission rates;Recommendation;Recording of previous events;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Resources;Risk;Risk Adjustment;Science;Scientist;Series;skills;standard of care;success;System;Training;treatment pattern;trend;United States National Institutes of Health;unstructured data;Work

PROJECT_TITLE: Outpatient Worsening Heart Failure in an Integrated Health Care Delivery System: An Innovative Approach to Characterizing a Novel Clinical Entity

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Cardiovascular;Congenital Structural Anomalies;Heart Disease;Pediatric;Rare Diseases

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: This proposal will investigate the molecular mechanisms of a new type of lysosome storage disease that causes severe defects in the heart and bone development of children. Our findings will shed light on the development of its treatment strategies.

PI_NAMEs: LI, MING  (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Address;Affect;Autophagocytosis;Binding;Biogenesis;Bone Development;Cardiac Edema;cardiogenesis;Cardiomegaly;Cell Physiology;Cells;Cessation of life;Child Development;Child Health;Clustered Regularly Interspaced Short Palindromic Repeats;Comparative Study;Data;Defect;Development;Disease;Down-Regulation;early childhood;Endocytic Vesicle;Endocytosis;enzyme activity;Enzymes;Functional disorder;Genes;genome-wide;Golgi Apparatus;heart defect;Human;Human Pathology;I-Cell Disease;Impairment;in vivo;Integral Membrane Protein;Journals;Knock-out;Label;Lysosomal Storage Diseases;lysosome membrane;Lysosomes;mannose 6 phosphate;Maps;Mass Spectrum Analysis;Membrane;Membrane Proteins;Metabolism;Modification;Molecular;monomer;Multienzyme Complexes;mutant;Mutation;Nutrient;Organelles;Paper;Pathway interactions;Patients;Phosphotransferases;Plasma;Recycling;Reporting;Research;Role;Signal Transduction;skeletal dysplasia;Sorting;Tail;Testing;Text;TFE3 gene;trafficking;transcriptome sequencing;treatment strategy;Up-Regulation;Vertebrates;Zebrafish

PROJECT_TITLE: Characterization of TMEM251 that causes a new type of severe lysosome storage disease

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project Narrative This grant focuses on the neuronal mechanisms that underlie decision-making processes that are based on knowledge of the external world. Many symptoms and underlying causes of neuropsychiatric disorders can be characterized as dysfunctions of these processes. Understanding the neuronal mechanisms that underlie these higher order decision making systems is a necessary step towards developing future diagnostic tools and therapeutic interventions for these neuropsychiatric disorders.

PI_NAMEs: HU, ERIC  (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: Affect;Algorithms;Area;Artificial Intelligence;Behavior;Behavioral Model;Behavioral Symptoms;Brain;Clinical;Code;Cognitive;cognitive neuroscience;cognitive system;Communication;Compulsive Behavior;computer framework;Decision Making;Development;Device or Instrument Development;Devices;diagnostic tool;Disease;Endowment;Environment;environmental change;Equilibrium;Failure;falls;Feedback;flexibility;Frequencies;Functional disorder;Future;Goals;Grant;Hippocampus;improved;Knowledge;Learning;learning algorithm;Link;Location;Major Depressive Disorder;Maps;Medial;Modeling;neural;neural circuit;neuronal circuitry;Neurons;neuroprosthesis;neuropsychiatric disorder;Neurosciences;Play;Population;Post-Traumatic Stress Disorders;Prefrontal Cortex;Primates;Process;Property;Psychiatry;Psychological reinforcement;Research;Rewards;Role;rumination;Schizophrenia;Structure;success;Symptoms;System;Testing;Therapeutic Intervention;Theta Rhythm;Update;Work

PROJECT_TITLE: Prefrontal-Hippocampal Interactions during Model-Based Learning


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Genetics;Immunization;Immunotherapy;Lung;Lung Cancer;Pancreatic Cancer;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The Jacks laboratory has pioneered the use of genetic engineering and genome editing to develop highly sophisticated models of human cancer. This proposal highlights novel research directions in the areas of tumor evolution and tumor-immune interactions. Results from these studies are expected to inform new strategies for treating human cancer.

PI_NAMEs: JACKS, TYLER E. (contact)

PROGRAM_OFFICER_NAME: LIU, YIN

PROJECT_TERMS: Antigens;Area;Cancer Biology;cancer cell;Cancer Control;Cancer Model;Cancer Patient;cancer type;Cancer Vaccines;cell type;Cells;clinical translation;CRISPR/Cas technology;Data Set;Development;Disease Progression;Dissociation;Evolution;experimental study;Foundations;Functional disorder;Gene Expression;Genes;Genetic Engineering;genetic profiling;Genetically Engineered Mouse;genome editing;Human;human model;Immune;Immune system;Immunotherapy;improved;In Situ;Laboratories;Lung Adenocarcinoma;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Modeling;Molecular;mouse model;Nature;novel;novel therapeutic intervention;Organoids;Pancreatic Ductal Adenocarcinoma;Pathway interactions;Pre-Clinical Model;Preventative vaccination;Research;response;single cell analysis;Specimen;System;T cell response;T-Cell Activation;T-Lymphocyte;technology development;Time;tool;transcriptomics;tumor;tumor microenvironment;tumor progression;vaccine strategy;Vaccine Therapy

PROJECT_TITLE: Studying factors controlling cancer progression and immune recognition in mouse models


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE Pancreatic cancer is a leading cause of cancer mortality with few effective therapies. This project will develop a novel immunotherapy that we show has pronounced therapeutic activity in preclinical animal models. We will uncover the mechanistic basis for the observed antitumor effects and create a novel immune therapy designed to change the standard of care for pancreatic cancer patient treatment.

PI_NAMEs: STROMNES, INGUNN MARGARETE (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Adoptive Cell Transfers;Advanced Malignant Neoplasm;Affinity;Animal Model;Animals;Antigen Presentation;antigen-specific T cells;Antigens;antitumor effect;Antitumor Response;base editor;Biological Assay;Blood Vessels;Bypass;Cancer Etiology;Cancer Model;Cancer Patient;Carcinoma;Cell Death;Cell Physiology;Cell Therapy;cell type;Cells;cellular engineering;Characteristics;chimeric antigen receptor;Chronic;Clinical;Coculture Techniques;comparative efficacy;CRISPR/Cas technology;cytokine;Cytometry;Cytotoxic T-Lymphocytes;Data;Defect;Diagnosis;Disease;effective therapy;Endothelial Cells;engineered T cells;exhaustion;Extracellular Matrix;Fibroblasts;gene editing technology;Gene Modified;Genetic Engineering;Human;human disease;Immune;immune checkpoint blockade;Immune Evasion;immunoregulation;Immunotherapy;In Vitro;in vivo;innovation;Knock-in Mouse;Knowledge;Learning;Legal patent;Macrophage;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Mesenchymal;mesothelin;Modeling;mortality;mouse model;Mus;mutant;Myelogenous;Myeloid Cells;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;overexpression;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Patients;Pharmaceutical Preparations;Phase I Clinical Trials;pre-clinical;Preclinical Testing;Predisposition;Primary Neoplasm;Production;progenitor;programmed cell death protein 1;programs;Proteins;public health relevance;Receptor Signaling;Regulatory T-Lymphocyte;Reporter;Resistance;response;Role;Safety;safety testing;screening;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Specificity;standard of care;stem;T cell differentiation;T cell infiltration;T cell response;T cell therapy;T-Cell Receptor;T-Lymphocyte;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapy design;therapy resistant;tool;Toxic effect;Toxicity Tests;transcription factor;Translating;Treatment Efficacy;tumor;Tumor Antigens;Tumor Immunity;tumor microenvironment;tumor xenograft;vector;Xenograft Model

PROJECT_TITLE: Enhancing engineered T cell therapeutic efficacy for the treatment of pancreatic ductal adenocarcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Orphan Drug;Precision Medicine;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE  Although half of patients with soft tissue sarcoma develop distant metastases after radiation therapy and surgery, there are currently no biomarkers to identify patients who would benefit from adjuvant systemic therapy and no known genetic alterations that mediate soft tissue sarcoma response to radiation therapy. We propose to use circulating tumor DNA analysis to identify patients at high risk of relapse who could benefit from additional therapy and discover genetic alterations that mediate radiation response. This work will lay the foundation for future clinical trials incorporating circulating tumor DNA analysis and tumor genomics to personalize treatment approaches and improve outcomes in patients with soft tissue sarcomas and other malignancies treated with radiation therapy.

PI_NAMEs: MODING, EVERETT JAMES (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Adult;Aftercare;Architecture;Biological Markers;Biology;Blood specimen;Cancer Biology;Cancer Patient;Cancer Personalized Profiling by Deep Sequencing;cancer therapy;Cell Line;Cells;Clinical;Clinical Trials;Combined Modality Therapy;Computational Biology;Consolidation Therapy;Data;design;Disease;Distant Metastasis;DNA analysis;Doctor of Philosophy;experimental study;External Beam Radiation Therapy;Foundations;Future;Gene Expression;Genetic;Genetic Determinism;Genomics;Goals;high risk;Histologic;Human;Hybrids;Immunotherapy;improved;improved outcome;individual patient;insight;K-Series Research Career Programs;Knowledge;Laboratories;Localized Disease;Malignant Neoplasms;Mediating;Mediator;medical schools;Medicine;Mentors;Mentorship;Mesenchymal Cell Neoplasm;Modeling;Modernization;Molecular;Monitor;mouse model;Mutation;new combination therapies;novel;Operative Surgical Procedures;Outcome;participant enrollment;patient response;Patient-Focused Outcomes;Patients;Pattern;peripheral blood;personalized medicine;Phase II Clinical Trials;Physicians;Plasma;pre-clinical;Pre-Clinical Model;predicting response;Primary Neoplasm;Probability;professor;prognostic model;programs;prospective;Radiation Oncology;radiation resistance;radiation response;Radiation therapy;Radiation Tolerance;Radiobiology;radioresistant;Radiosurgery;Randomized;randomized trial;Recurrence;Relapse;relapse prediction;relapse risk;Research;Research Proposals;Residual Neoplasm;response;Risk Factors;Role;Sampling;Sarcoma;Scientist;Soft tissue sarcoma;symposium;Systemic Therapy;Systems Biology;Techniques;Testing;therapy development;therapy resistant;tool;Training;transcriptomics;translational research program;Treatment-related toxicity;tumor;tumor DNA;tumor eradication;tumor immunology;tumor microenvironment;Tumor Tissue;Universities;Validation;Work

PROJECT_TITLE: Non-invasive characterization of human soft tissue sarcoma response to radiation therapy

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: PORTLAND

ORG_NAME: NORTHWEST PORTLAND AREA INDIAN HLTH BD

ORG_STATE: OR

PHR: The Northwest Portland Area Indian Health Board (NPAIHB) has a long-standing health research relationship with Oregon Health & Science University and Portland State University. With its two academic partners, the NPAIHB will implement two training programs for American Indian and Alaska Native researchers, including a graduate and undergraduate fellowship program with a strong population health sciences focus. Similarly, our high school enrichment program for tribal students will use a population health sciences lens to engage the tribal students in the sciences – our efforts are designed to help reduce disparities for tribal people regionally and nationwide.

PI_NAMEs: BECKER, THOMAS MARK (contact)

PROGRAM_OFFICER_NAME: RICHARDS, CRYSTAL LYNETTE

PROJECT_TERMS: Academia;Accreditation;Address;Advisory Committees;Alaska Native;Alaska Native population;American Indian Population;American Indians;Area;assault;cancer prevention;Career Mobility;Chronic Disease;Collaborations;Communities;community advisory board;COVID-19;COVID-19 pandemic;Data;design;Development;disparity reduction;distrust;Educational Grants;Evaluation;experience;Faculty;Fellowship;Fellowship Program;Fright;Funding;Goals;Grant;hands on research;Health;Health Alliance;health data;health disparity;Health Priorities;health science research;Health Sciences;Health Status;Healthcare;high school;Human Resources;improved;Indigenous;Individual;Infrastructure;innovation;Institution;interest;Leadership;lens;member;Mentors;Methods;Modification;Native American Research Center for Health;Native-Born;Northwest Tribe;Oregon;Population;population health;Population Sciences;Prevalence;programs;Qualifying;racial health disparity;Research;Research Personnel;Research Support;Research Training;response;Science;skills;Strategic Planning;Students;Training;Training Programs;training project;tribal community;Tribal group;tribal health;tribal leader;Tribal-academic partnership;Tribes;twelfth grade;undergraduate student;United States Indian Health Service;United States National Institutes of Health;Universities;Vocational Guidance;Work

PROJECT_TITLE: Strengthening Indigenous Health and Science Research: NW NARCH Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PROJECT_TERMS: Administrator;Advisory Committees;American Indian community;Area;Collaborations;Communities;Community Health;COVID-19;design;Development;Electronics;Epidemiology;Evaluation;experience;Faculty;Funding;Goals;Health;Health Sciences;Indigenous;Investments;Leadership;meetings;member;Mentors;Native American Research Center for Health;Newsletter;Oregon;Outcome;Pacific Northwest;Persons;Process;programs;Reporting;Research;Research Personnel;Research Project Grants;Research Training;Resolution;Science;Scientist;Strategic Planning;Students;success;Training;training opportunity;training project;Transplantation;Travel;Tribal group;tribal health;Tribes;Trust;Underrepresented Minority;United States Indian Health Service;United States National Institutes of Health;Universities;web site;Work

PROJECT_TITLE: Administrative Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-N]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Pediatric;Rare Diseases

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE: Hirschsprung disease (HSCR), or congenital aganglionosis, results from defects in enteric neural crest cell precursor (ENCC) development to enteric neurons in a sex-biased manner. We propose studies to improve HSCR risk prediction from patient genome sequence, advance the mechanistic understanding of HSCR at the genetic and cellular levels, and identify the rate-limiting genetic steps suitable for therapeutics. Our goals are to provide a genetic paradigm for uncovering the pathophysiology of a sex-biased complex multifactorial disorder.

PI_NAMEs: CHAKRAVARTI, ARAVINDA  (contact)

PROGRAM_OFFICER_NAME: KOSTER, MARANKE IRENE

PROJECT_TERMS: Adult;Alleles;Atlases;Attention;Attenuated;Award;Benign;Biological Assay;Biological Process;Birth;Cell Count;Cell Cycle;Cell Survival;cell type;Cells;Child;Complex;Congenital Megacolon;CRISPR screen;CRISPR/Cas technology;Data;de novo mutation;Defect;Development;Diet;Disease;disorder risk;Dose;Elements;Embryo;Enhancers;Enteral;Enteric Nervous System;exome;Failure;Functional disorder;gene discovery;Gene Expression;Gene Expression Profiling;Gene Modified;gene regulatory network;Genes;Genetic;genetic analysis;Genetic Diseases;Genetic Epistasis;Genetic study;Genetic Transcription;genetic variant;Genome;Genomics;Genotype;Goals;gut colonization;Heritability;Human;Human Genetics;improved;In Situ Hybridization;In Vitro;in vivo;insight;knock-down;Length;Literature;Location;Mediating;Molecular;Molecular Genetics;mouse model;Mus;Mutant Strains Mice;Mutation;nervous system development;Neural Crest Cell;Neurons;novel;NRG1 gene;offspring;Other Genetics;Parents;Pathogenicity;Pathway interactions;Patients;Penetrance;Phenotype;Population Attributable Risks;Proliferating;promoter;Quantitative Reverse Transcriptase PCR;RARB gene;response;risk prediction;RNA;segregation;sex;Sex Bias;sex variable;Signal Transduction;single-cell RNA sequencing;Small Interfering RNA;Source;Testing;Therapeutic;Time;Tissue-Specific Gene Expression;Tissues;transcription factor;transcriptome;transcriptome sequencing;Tretinoin;Untranslated RNA;Validation;Variant;Vitamin A;whole genome

PROJECT_TITLE: Genetic Analysis of Hirschsprung Disease - Renewal

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


PROJECT_TERMS: Address;Advertising;career;career development;Collaborations;college;Competence;COVID-19;Degree program;Degree requirements;Development;Development Plans;Education;Educational process of instructing;Educational workshop;Enrollment;Environmental Health;Environmental Science;Evaluation;experience;Fellowship;Fellowship Program;Fostering;Foundations;Funding;Goals;graduate student;Grant;Health;health science research;Health Sciences;Idaho;improved;Indigenous;Individual;Institution;interest;lens;meetings;Mentors;Mentorship;Methods;minority student;Native American Research Center for Health;non-Native;Online Systems;Oregon;Participant;peer;peer coaching;Persons;population health;Population Sciences;programs;Qualifying;recruit;Reduce health disparities;Research;Research Activity;Research Personnel;Research Project Grants;Research Training;Resources;role model;Schedule;Science;science education;Scientific Advances and Accomplishments;Scientist;skills;Students;success;summer research;symposium;tool;Training;Training Programs;tribal community;Tribal group;tribal health;Tribes;undergraduate student;United States National Institutes of Health;Universities;Washington;Work

PROJECT_TITLE: Research Fellowships for NW Tribal Population Health Sciences Students


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

PHR: PROJECT NARRATIVE Patients with gastroparesis often suffer with chronic gastrointestinal symptoms that are not adequately treated due to both a lack of understanding of the underlying causes and lack of effective treatments. The studies proposed by Temple University Gastroparesis Clinical Center for the NIH Gastroparesis Clinical Research Consortium will help improve the understanding, diagnosis, and treatment of patients with gastroparesis.

PI_NAMEs: PARKMAN, HENRY PAUL (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: 2019-nCoV;Adrenal gland hypofunction;Ancillary Study;Antibodies;Antral;Area;Autoimmune;Autoimmune Diseases;Biopsy;Biopsy Specimen;Buspirone;Cells;Characteristics;Chronic;Clinic;Clinical;clinical center;Clinical Research;Clinical Trials;comorbidity;Development;diabetic;diabetic gastroparesis;Diagnosis;Disease;Distress;Dyspepsia;early satiety;Eating;effective therapy;Endocrine;Enrollment;Etiology;Evaluation;feeding;follow-up;Functional disorder;Funding;Fundoplication;Future;Gastric Emptying;gastrointestinal symptom;Gastroparesis;Goals;Grant;Histologic;Human;Immune;improved;improved outcome;Intake;interest;Investigation;Learning;Manuscripts;minority patient;Multicenter Studies;multidisciplinary;Muscle;National Institute of Diabetes and Digestive and Kidney Diseases;participant enrollment;Pathologic;Pathology;patient population;Patient-Focused Outcomes;Patients;Peripheral Nervous System Diseases;persistent symptom;Physiological;Publications;Pyloric sphincter structure;Qualifying;Questionnaires;Radionuclide Imaging;recruit;Registries;Research;Sampling;Serum;Severities;Stomach;Suggestion;symptom treatment;Symptoms;Syndrome;targeted treatment;Techniques;Testing;Thick;Tissue Banks;Tissue Sample;Treatment outcome;treatment response;treatment strategy;United States National Institutes of Health;Universities;urban area


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Immunization;Infectious Diseases;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Vaccine Related

PROJECT_TERMS: 2019-nCoV;Advisory Committees;age group;Area;Awareness;Benchmarking;Cancer Control;cancer prevention;career;Career Choice;catalyst;Cessation of life;college;Communicable Diseases;comorbidity;Containment;Country;COVID-19 pandemic;Data Science;Death Rate;Development;Discipline;Disease;disorder prevention;Education;Elderly;Electronics;eleventh grade;emerging pathogen;Environmental Health;Environmental Science;Epidemiology;experience;Fellowship;field study;fighting;forging;Funding;Future;Genetic;genetic variant;Goals;graduate school;Grant;Health;health practice;health science research;Health Sciences;high school;High School Student;Immunization;Immunology;Incidence;Indigenous;Infection;interest;Internships;Laboratories;lens;Mentors;Methods;Native American Research Center for Health;news;Outcome;pandemic disease;peer coaching;Personal Satisfaction;Persons;population health;Population Sciences;preservation;Prevention program;Process;programs;Public Health;Public Health Schools;Published Comment;recruit;Research;Research Personnel;Research Project Grants;Research Training;Role;Science;science education;Scientist;Side;social media;social science research;student participation;success;summer internship;summer research;Techniques;Training;tribal community;Tribal group;tribal health;tribal member;Tribes;undergraduate student;Universities;vaccine development;vaccine safety;virology;Work;Youth

PROJECT_TITLE: Forging our Futures: Studying Science to Protect Tribal Health


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

PHR: PROJECT NARRATIVE/RELEVANCE Individuals with an underlying HIV-infection have an increased risk of developing AIDS-related malignancies. Kaposi sarcoma-associated herpesvirus (KSHV) is the necessary causal agent for Kaposi's sarcoma and is a cofactor in B cell lymphoproliferative disorders observed in AIDS patients. Understanding how KSHV is transmitted amongst the population is a necessary first step in creating a vaccine to prevent the spread of KSHV worldwide. The results from the proposed studies utilizing the nonhuman primate model should help elucidate and define the mechanisms involved in KSHV transmission.

PI_NAMEs: WONG, SCOTT W (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;acute infection;Affect;Africa South of the Sahara;AIDS related cancer;Anatomy;animal resource;B-Cell Lymphomas;B-Lymphocytes;Bacterial Artificial Chromosomes;Binding;Cell Culture Techniques;cell type;Cells;Cellular biology;Child;Chimera organism;cofactor;Data;density;detection assay;Development;Disease;experimental study;Fibromatoses;gamma-2 herpesvirus;Generations;Genome;Genomics;Glycoproteins;Goals;Herpesviridae;Herpesviridae Infections;HIV Infections;Homologous Gene;Human;Human Herpesvirus 8;Immune response;immunodeficiency;Immunology procedure;In Vitro;in vivo;Individual;Infection;Inflammation;Intravenous;Investigation;Kaposi Sarcoma;Kinetics;latent infection;Lesion;Life;Ligature;Lymphoproliferative Disorders;Macaca mulatta;Mesenchymal;Modeling;Molecular;Molecular Biology;Molecular Genetics;mRNA Expression;Multicentric Angiofollicular Lymphoid Hyperplasia;nonhuman primate;novel;Oral;Oral cavity;Oral mucous membrane structure;oral tissue;Pathogenicity;Pathologic;Pathology;Patients;Periodontitis;Physiological;Plasma Cells;Population;Predisposition;prevent;Primates;Procedures;protein expression;receptor;receptor expression;receptor function;Recombinants;Research Personnel;response;Retroperitoneal Space;Rhadinovirus;Risk;Rodent;Role;Route;Saliva;Site;SIV;Species Specificity;System;Tissues;trafficking;transmission process;Vaccines;Variant;Viral;Viral Load result;viral transmission;Virus;Virus Diseases

PROJECT_TITLE: Oral transmission of KSHV using rhesus macaque rhadinovirus model


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Microbiome

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Despite that majority of microbes found in nature exist and function in spatially organized communities, our current basic understanding of microbes is heavily based on the studies performed in liquid cultures. Therefore, the next frontier is to understand the group behavior and physiology of microbes with a pre-defined spatial context and engineer synthetic consortia in a well-defined 3D framework for desired functional outcomes. The proposed research is relevant to public health because expanding our fundamental understanding of naturally- occurring communities of microbes will enable us to better control/treat clinically relevant biofilms and engineer biomaterials useful for human health.

PI_NAMEs: SIM, SEUNGHYUN  (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TITLE: Spatially Structured Synthetic Consortia of Microbes to Understand and Engineer Cells in 3D Environments


ORG_NAME: DREXEL UNIVERSITY

PHR: Project Narrative  A therapeutic strategy to induce neovascularization of tissues and biomaterials would represent a major breakthrough in the treatment of ischemic tissue disorders, dysfunctional wound healing, and the replacement of damaged tissues. The proposed studies are designed to improve our understanding of how the body naturally orchestrates successful blood vessel growth, and then to apply these principles to the design of novel biomaterials that harness these processes to promote vascularization.

PI_NAMEs: SPILLER, KARA LORRAINE (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: angiogenesis;Atherosclerosis;Autoimmune Diseases;Behavior;Biocompatible Materials;Blood Vessels;Brain Ischemia;cancer therapy;Cell secretion;Cell Therapy;chronic wound;Complex;Cues;Data;design;Diabetes Mellitus;directed differentiation;Disease;efficacy testing;Endothelial Cells;Exhibits;Expression Profiling;Functional disorder;Gene Expression;Goals;Growth;healing;Heart;Hindlimb;Human;immunoregulation;Impaired healing;Impairment;improved;In Vitro;in vivo;Inflammatory;Inflammatory Response;Interleukin 4 Receptor;Interleukin-4;Ischemia;Kinetics;Leukocyte Trafficking;Macrophage;Mediating;Mediator;migration;mimicry;Modeling;monocyte;mouse model;Mus;Myocardial Ischemia;neovascularization;novel;novel strategies;particle;Pathologic Neovascularization;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Phenotype;Population;Process;protein expression;receptor;recruit;regeneration function;regenerative;Regulation;Regulatory T-Lymphocyte;response;response to injury;revascularization;Signal Transduction;Stimulus;Supporting Cell;Testing;Therapeutic;Time;Tissue Engineering;Tissues;Vascularization;Work;wound healing

PROJECT_TITLE: Understanding and Controlling Macrophage Behavior in Angiogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-V(02)M]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health

ORG_CITY: SIOUX FALLS

ORG_NAME: AVERA MCKENNAN

ORG_STATE: SD

PHR: SoDakPCTN Project Narrative: Impact: Given the level of health disparities in our region, particularly amongst the AI populations, coupled with the remote nature of our rural communities, a mechanism for development of pediatric clinical trials research will not only grow pediatric research, it will improve health of children in South Dakota.

PI_NAMEs: ELLIOTT, AMY J (contact);WANG, KATHERINE

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Adoption;American Indian Population;American Indians;Area;career development;Child;Child Health;Childhood;Cities;Clinic;Clinical;Clinical Research;Clinical Trials;Clinical Trials Network;Clinics and Hospitals;cohort;Collaborations;collaborative environment;Communication;Communities;community based research;community engaged approach;Community Healthcare;community partners;community research;Coupled;critical access hospital;design;Development;dissemination strategy;Education;Environment;Feedback;follow-up;Foundations;frontier;Funding;Funding Agency;Growth;Health;health disparity;Health education;Health Status;Health system;Healthcare;Hospitals;improved;Infrastructure;Inpatients;Institution;Intervention;Knowledge;Legal;Location;Longitudinal Studies;medical schools;meetings;Mentorship;Nature;neglect;Observational Study;Operations Research;Outcome;Outpatients;Pediatric cohort;pediatric health outcomes;Pediatric Research;Pine Ridge Indian Reservation;Population;Practice based research;Process;programs;Recording of previous events;Research;Research Activity;research data dissemination;Research Infrastructure;Research Personnel;Resources;routine practice;Rural;Rural Community;Sioux Falls;Site;skills;South Dakota;Structure;success;telehealth;Training;Training Activity;Translating;Translations;tribal Nation;Tribes;Trust;Universities;Work

PROJECT_TITLE: South Dakota Pediatric Clinical Trials Network (SoDakPCTN)


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Infectious Diseases;Pediatric;Pediatric - AIDS;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: SEATTLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Pre-exposure prophylaxis (PrEP) HIV prevention tools are promising, with tenofovir (TFV)-based daily oral PrEP and the dapivirine vaginal ring (DPV-VR) recommended by WHO for cisgender women at-risk for HIV. Retail pharmacies can increase options for reaching at-risk individuals with PrEP and efforts are underway to define pathways for pharmacy-delivered PrEP in Kenya. Through close collaboration with the Kenya Ministry of Health, we will expand on our successful pilot to offer both daily oral PrEP and the DPV-VR and prospectively ascertain PrEP outcomes (initiation, persistence, adherence) among adolescent girls and young women in a cluster RCT at 20 pharmacies in Kisumu, Kenya–a region with an HIV prevalence of up to 28% among women–in a effectiveness-implementation hybrid study designed to expedite translation into practice by evaluating clinical effectiveness alongside implementation and cost outcomes.

PI_NAMEs: BUKUSI, ELIZABETH ANNE;PINTYE, JILLIAN  (contact)

PROGRAM_OFFICER_NAME: YATES, FRANKLIN WILLEM

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Africa;AIDS prevention;arm;cis-female;Client;Client satisfaction;Climate;Clinic;Clinical effectiveness;cofactor;Collaborations;Contraceptive methods;Contraceptive Usage;cost;cost effective;cost effectiveness;cost estimate;cost outcomes;Counseling;County;Dapivirine;Data;Dedications;design;economic impact;effectiveness testing;effectiveness/implementation hybrid;effectiveness/implementation study;Family Planning;Female Adolescents;Focus Groups;Hair;Health;Health care facility;High Risk Woman;HIV;HIV Seronegativity;implementation evaluation;implementation outcomes;improved;Incidence;Individual;Injectable;Intervention;Kenya;mathematical model;Measures;Mental Depression;microcosting;Modeling;Motion;novel;novel strategies;Nurses;Oral;Outcome;Participant;Pathway interactions;Pharmacists;Pharmacy facility;pill;Positioning Attribute;pre-exposure prophylaxis;Prevalence;Prevention;primary outcome;Proctor framework;programs;prospective;Provider;Public Facilities;Qualitative Evaluations;Quality of Care;Randomized;Recommendation;Research Design;Research Infrastructure;reversible contraceptive;Risk;satisfaction;scale up;secondary outcome;social stigma;Southern Africa;Standard Model;success;System;Technology;Tenofovir;Time;tool;Translations;Vaginal Ring;Wait Time;Woman;young woman

PROJECT_TITLE: Enhancing PrEP outcomes among Kenyan adolescent girls and young women with a novel pharmacy-based PrEP delivery platform

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This proposal focuses on the development of computational methods for identifying aberrations in gene expression. In particular, we propose to develop methods for identifying allele-specific expression, for identifying mutations that directly impact gene expression in reporter assays, and for identifying which parts of the genome regulate which genes. We expect this work to result in more effective identification of causal variants and a higher diagnosis rate for currently undiagnosed patients of a wide variety of diseases, as well as potential leads toward the design of therapeutics.

PI_NAMEs: MAJOROS, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Alleles;Biological Assay;causal variant;Cells;Collaborations;Complex;Computing Methodologies;CRISPR interference;Data;design;Development;Diagnosis;Disease;Doctor of Philosophy;Enhancers;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic disorder diagnosis;genetic variant;Genome;genome wide association study;Human Genome;Individual;Methods;Modern Medicine;Mutation;Patients;Positioning Attribute;Regulatory Element;Reporter;Science;Statistical Methods;Statistical Models;Therapeutic;Untranslated RNA;Variant;Work

PROJECT_TITLE: Computational Methods for Investigating the Genetics of Gene Regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]