NIH_SPENDING_CATS: Aging;Brain Disorders;Genetics;Human Genome;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative The greatest risk factor for developing Parkinson’s disease, outweighing all others, is age. However, it is unclear how aging predisposes the brain to PD. This project studies the mechanism of how microglia become senescent, characterizes the senescent microglia, and determines the impact of senescent microglia on dopaminergic neurons using human Parkinson’s disease postmortem brains and human microglia derived from induced pluripotent stem cells.

PI_NAMEs: CHOI, INSUP  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Affect;Age;age effect;age related;Aging;aging process;aging related disease;alpha synuclein;Alzheimer's disease model;Animal Disease Models;Animal Model;anti aging;Area;Autophagocytosis;Autophagosome;Autopsy;Bacteria;Biological Assay;Blood;Brain;Brain Diseases;brain tissue;Cathepsins;Cell Aging;cell injury;Cells;Cellular Morphology;Chronic;cognitive impairment in Parkinson's;comparison control;CRISPR/Cas technology;Cyclin-Dependent Kinase Inhibitor;Data;Degradation Pathway;Disease;disease phenotype;Disease Progression;DNA Damage;dopaminergic neuron;Essential Genes;Excision;Exhibits;Freezing;Gene Expression Profile;Genes;Genetic;Genomics;Health;healthspan;Homeostasis;Human;human induced pluripotent stem cells;In Situ Hybridization;induced pluripotent stem cell;Inflammation;inflammatory marker;inhibition of autophagy;insight;Invaded;knock-down;Ligation;Lipofuscin;Lysosomes;Macrophage;Mass Spectrum Analysis;Microglia;misfolded protein;Molecular Profiling;motor impairment;Movement Disorders;multiple omics;Mus;Neurodegenerative Disorders;Neuroglia;neuronal survival;Neurons;neuroprotection;Organ;Organelles;Parkinson Disease;pars compacta;Pathogenicity;Pathway interactions;Patients;Phenotype;prevent;Proliferating;protein aggregation;Proteins;proteomic signature;Reporting;Research;response;Risk Factors;RNA;Role;senescence;senescence associated secretory phenotype;senescent cell;single nucleus RNA-sequencing;SNAP receptor;Substantia nigra structure;Surveys;syntaxin;Technology;Testing;therapeutic target;transcriptome sequencing;transcriptomics

PROJECT_TITLE: Roles of autophagy in microglial senescence and Parkinson's disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE This proposal will define the strategies employed by the important human pathogen Acinetobacter baumannii to combat calprotectin-dependent zinc starvation during the pathogenesis of pneumonia. All microbial pathogens require zinc acquisition and metabolism to colonize the vertebrate host; therefore, these studies will be broadly applicable to numerous infectious diseases. Moreover, this work has the potential to uncover new principles in metal biology and cell wall synthesis that may lay the groundwork for the design of intervention measures to target these emerging infectious threats.

PI_NAMEs: CHAZIN, WALTER J.;GIEDROC, DAVID P.;SKAAR, ERIC P (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Antibiotics;Antimicrobial Resistance;Area;Bacteremia;Bacteria;Bacterial Infections;Binding;Biological;Biology;cell envelope;Cell Wall;chelation;Client;clinically significant;combat;Communicable Diseases;Data;Deposition;deprivation;dietary;dietary restriction;Dietary Zinc;Disease;Enabling Factors;Endocarditis;Enzymes;Event;experimental study;Family;Genes;Genome;genomic locus;Growth;Guanosine Triphosphate Phosphohydrolases;Homeostasis;Host Defense;human pathogen;Immune;Infection;Intake;Intensive Care Units;Leukocyte L1 Antigen Complex;lung colonization;Lytic;Macromolecular Complexes;Measures;Mediating;member;Meningitis;Metabolism;metalloenzyme;Metalloproteins;Metals;Modeling;mortality;Names;new therapeutic target;Nutrient;nutrient deprivation;Nutritional;Nutritional Immunity;Nutritional Requirements;Organism;Outcome;pathogen;Pathogenesis;pathogenic bacteria;pathogenic microbe;Peptidoglycan;Phenotype;Physiological;Pneumonia;predictive modeling;Process;Proliferating;Property;Proteins;Public Health;Recycling;Regulation;Research;Resistance;Respiratory Tract Infections;response;Sentinel;Series;Signal Transduction;single cell genomics;Starvation;Technology;Testing;therapeutic development;Therapeutic Intervention;therapy design;Urinary tract infection;Variant;virtual;Work;Wound Infection;Zinc;Zinc deficiency;zinc-binding protein

PROJECT_TITLE: Host-mediated zinc sequestration during Acinetobacter baumannii infection

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IIDA-G(80)]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative LAMA2-deficient congenital muscular dystrophy (LAMA2-CMD) is a genetic disease that causes skeletal muscle and nerve damages in children. We will evaluate the therapeutic benefits of LAMA1 upregulation to compensate for the lack of LAMA2 in mouse and patient-derived cellular models. These findings will pave the way towards the development of a mutation-independent therapeutic interventions for LAMA2-CMD and other muscular dystrophies.

PI_NAMEs: VOCKLEY, GERARD  (contact)

PROGRAM_OFFICER_NAME: CARIFI, EMILY FORAN

PROJECT_TERMS: adenovirus mediated delivery;Affect;Apoptosis;attenuation;Bioenergetics;Cell model;cell motility;Cell Reprogramming;Cells;Cessation of life;Child;Clinical;Clinical Trials;Compensation;congenital muscular dystrophy;Contracture;cost;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Dedications;Defect;Development;Disease;disease model;disease phenotype;Dose;Economics;efficacy evaluation;Evaluation;Event;experimental study;Fibrosis;Functional disorder;Future;Gene Activation;Genes;Genetic;Genetic Diseases;Genetic Models;Health Expenditures;Human;Impairment;improved;in vivo;Individual;Inflammation;Life;life span;Mediating;migration;miniaturize;Mitochondria;Modeling;mouse model;Mus;Muscular Dystrophies;muscular dystrophy mouse model;Mutation;mutation correction;myelination;Nature;nerve damage;neuromuscular function;novel;Outcome;Pathogenicity;patient population;Patients;Physical therapy;postnatal;pre-clinical;preclinical evaluation;premature;Production;promoter;Property;Proteins;Respiration;Respiratory physiology;Safety;Schwann Cells;Services;Skeletal Muscle;Splice-Site Mutation;symptom management;System;Technology;Testing;Therapeutic;therapeutic evaluation;Therapeutic Intervention;Therapeutic Uses;Toxic effect;Toxicology;Transcription Coactivator;translational approach;Translations;United States;Up-Regulation;ventilation

PROJECT_TITLE: Therapeutic genetics and disease modeling in LAMA2-CMD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Auditory recognition disorders in speech and language are typically thought to result from neurological abnormalities in the central auditory system rather than the periphery. Yet little is known about the neural mechanisms that underlie the type of complex audition that we routinely rely on in real-world scenarios, particularly for primates. This innovative proposal aims to address this issue by examining the perceptual and neural circuitry supporting vocal recognition in dynamic cocktail party environments.

PI_NAMEs: MILLER, CORY T (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acoustics;Address;Animal Model;Attention;attentional control;Auditory;Auditory system;Behavior;Behavior Control;Behavioral;Behavioral Paradigm;Brain;Callithrix;Callithrix jacchus jacchus;Communication;Complex;computer generated;computerized tools;Computers;Cues;design;directed attention;Disease;Environment;Experimental Designs;experimental study;Feedback;Hippocampus;Human;Individual;innovation;Knowledge;Laboratories;Language;Learning;machine learning algorithm;Methods;Modeling;Modernization;Monkeys;Nature;neural;neural circuit;neural correlate;Neurologic;neuromechanism;Neurons;neurophysiology;nonhuman primate;novel;Positioning Attribute;Prefrontal Cortex;Primates;Process;Property;Role;Series;Signal Transduction;social;Speech;Structure;System;Testing;Time;virtual;Voice;wireless;Work

PROJECT_TITLE: Neural basis of vocal signal recognition during natural communication

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE Adolescent and young adult (AYA) survivors of childhood cancer are at risk for second cancers and other chronic health conditions (so-called “late effects”), yet their engagement in long-term follow-up care declines as they transition to adulthood and adult-oriented follow-up care. We aim to fill a significant knowledge gap by testing an adaptive re-engagement intervention specifically targeting AYA who are not currently engaged in follow-up care, and that aims to enhance appointment making, attendance and self-management. The goal is to identify optimal intervention strategies to meet an AYA’s individual needs for re-engagement in care and self-management, ultimately reducing morbidities and health disparities in this population.

PI_NAMEs: SCHWARTZ, LISA A (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: adaptive intervention;Address;Administrator;Adolescent and Young Adult;Adult;analytical method;Appointment;Awareness;barrier to care;behavioral economics;Cancer Survivorship;Caring;Child;childhood cancer survivor;Chronic;clinical care;comparative efficacy;comparison intervention;cost;Data;demographics;design;Diagnosis;digital;digital health;digital tool;disparities in morbidity;Disparity;disparity reduction;Evaluation;Face;follow-up;Friends;Future;future implementation;Goals;Guidelines;Health;health disparity;health goals;health management;health plan;Health Services Accessibility;Healthcare;implementation barriers;implementation cost;implementation facilitators;improved;improved outcome;indexing;Individual;innovation;Insurance;Intervention;Intervention Studies;Interview;Knowledge;Knowledge Management;Late Effects;Letters;Life;Long-Term Survivors;Longterm Follow-up;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Monitor;Morbidity - disease rate;multidisciplinary;Nurses;Outcome;outcome disparities;Outcome Measure;Parents;Personal Satisfaction;Persons;Population;primary outcome;programs;Provider;Randomized;Recommendation;Recording of previous events;Recurrence;Reporting;Research;Resources;Risk;risk stratification;Second Primary Cancers;secondary outcome;Self Management;Sequential Multiple Assignment Randomized Trial;Social Work;Social Workers;Specific qualifier value;Standardization;Survivors;survivorship;System;Technology;Testing;Text Messaging;theories;Time;Touch sensation;transition to adulthood;treatment as usual;treatment effect;Treatment Efficacy;vulnerable adolescent;Vulnerable Populations;Work;Writing;young adult

PROJECT_TITLE: Re-Engaging AYA Survivors in Cancer-Related Healthcare (REACH): A Sequential Multiple Assignment Randomized Trial (SMART)

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Prostate Cancer;Racial and Ethnic Minority Health Research;Urologic Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: NARRATIVE Definitive diagnosis of prostate cancer (PCa) relies on the collection of multiple core needle biopsies and their histopathological analysis but the multifocal nature of PCa makes cancer foci easy to miss, leading to a high rate of false negative results. Elevated PCa incidence rates, aggressiveness and mortality are more substantial in African American than in Caucasian American men. Our studies seek to identify and validate specific functional and phenotypic profiles of mast cells and molecular signatures present in benign biospies collected from PCa patients to improve PCa diagnosis, also having implications in PCa race disparity.

PI_NAMEs: OSKERITZIAN, CAROLE A (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;Affect;African American;Age;Aging;Area;baby boomer;Benign;Biological;Biological Markers;Biopsy;Biopsy Specimen;cancer diagnosis;cancer health disparity;Cancer Patient;Caregivers;caucasian American;Cell Aggregation;Cell Count;Cells;Clinic;clinically relevant;clinically significant;Collection;Complex;computerized;Core Biopsy;cost effective;Data;Data Analyses;Death Rate;Development;Diagnosis;Diagnostic;Disease;disease disparity;Disparity;Doctor of Medicine;Early Diagnosis;Endowment;Ethnic Population;Evaluation;Faculty;Feasibility Studies;first responder;functional status;Future;Gene Expression Profiling;Genes;Goals;Grant;Health;high risk;Human;human tissue;Hypersensitivity;Image;Image Analysis;imaging modality;improved;Incidence;innovation;insight;interest;Laboratories;Lesion;Malignant neoplasm of prostate;Malignant Neoplasms;mast cell;Measures;Medical;member;men;Methods;Modality;Molecular;Molecular Profiling;Morbidity - disease rate;mortality;Mus;Nature;Normal tissue morphology;novel;Oncogenic;Oncologist;overexpression;Patients;Phenotype;Physicians;Pilot Projects;Population;Positioning Attribute;Predictive Value;Predisposition;Prevention;prisma;Property;Prostate;prostate biopsy;prostate cancer risk;Prostatic;Prostatic Tissue;quantitative imaging;Race;racial disparity;racial population;Research;Risk;Sampling;screening;Screening for Prostate Cancer;Site;Solid Neoplasm;Source;Sphingolipids;sphingosine 1-phosphate;success;Survey Methodology;Testing;Tissues;tumor;United States;urologic;Urology;validation studies;Variant

PROJECT_TITLE: Novel modalities for prostate cancer screening: mast cells as predictors of disease, disease aggressiveness and marks of disease disparity


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: Los Angeles

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Project Narrative Magnetoencephalography (MEG) and Electroencephalography (EEG) are non-invasive brain imaging tools for studying normal human cognition as well as neurological and psychiatric illnesses, including epilepsy, schizophrenia, obsessive-compulsive disorder, autism spectrum disorders, and Alzheimer’s disease. The neuroscience research community has an ongoing need for validated and documented open-source software to perform analysis and to facilitate reproducible and large-scale research involving electrophysiological data. This project continues to develop and support Brainstorm, open-source software that meets these needs with well-documented and tested novel analyses using MEG and EEG in combination with anatomical MRI and intracranial EEG data.

PI_NAMEs: LEAHY, RICHARD M (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Animal Model;Animals;Atlases;autism spectrum disorder;Behavior;Behavioral;behavioral response;Brain;Brain imaging;Clinical;Code;Cognition;cognitive neuroscience;Collaborations;Communities;Complex;Computer software;computerized tools;Data;Data Files;data format;data modalities;data repository;data resource;data structure;database structure;Development;Diffusion;distributed data;Documentation;Eastern Cooperative Oncology Group;Educational workshop;Electrodes;Electroencephalography;Electrophysiology (science);Environment;Epilepsy;Equilibrium;Event;Faculty;Head;High Frequency Oscillation;Human;Image;Imaging Device;imaging Segmentation;improved;In Vitro;in vivo;Individual;Infant;innovation;interest;interoperability;Java;Knowledge;Label;Lead;Link;Linux;Magnetic Resonance Imaging;Magnetoencephalography;Maintenance;Measures;Mental disorders;Methodology;Microelectrodes;Modeling;multimodality;neural;Neurologic;Neurons;neurophysiology;Neurosciences;Neurosciences Research;novel;Obsessive-Compulsive Disorder;Occupations;Online Systems;open source;Persons;Philosophy;Play;Postdoctoral Fellow;power analysis;Preparation;programs;Publishing;Pythons;Readability;Recording of previous events;Reporting;Reproducibility;Research;Research Design;Research Personnel;response;Role;Running;Schizophrenia;Sensory;Sleep;Sorting;Source;Staging;statistics;Stimulus;Students;Techniques;Testing;tool;Training;Validation;Visualization;Visualization software;Writing;X-Ray Computed Tomography

PROJECT_TITLE: BrainStorm: Highly Extensible Software for Advanced Electrophysiology and MEG/EEG Imaging

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEWCASTLE-UPON-TYNE

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: NORTHUMBRIA UNIVERSITY

ORG_ZIPCODE: NE1 8ST

PHR: Project Narrative  The mechanisms of emergence, or ‘waking up’, from general anesthesia with volatile anesthetics are poorly understood, and delays in emergence are associated with anxiety, confusion, operating room delays, and increased medical costs. If the mechanisms underlying emergence can be resolved, it may be possible to develop strategies for active promotion of recovery of consciousness. The aim of the experiments in this proposal, which are supported by significant preliminary data, is to define the role of astrocytes, a cell in the brain that supports neuron function, in regulating emergence.

PI_NAMEs: JOHNSON, SIMON C (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Agitation;Anesthesia procedures;Anesthetics;Animals;Anxiety;Arousal;Astrocytes;Brain;Brain region;Calcium Signaling;Cell Communication;Cell Culture Techniques;Cell model;cell type;Cells;Central Nervous System;Complex;Confusion;Conscious;Dangerousness;Data;Delirium;Development;Dose;Elderly;Electron Transport;Enterobacteria phage P1 Cre recombinase;Excision;experimental study;Exposure to;Functional disorder;General Anesthesia;Glutamates;Goals;Hypersensitivity;Impairment;In Vitro;in vivo;Injury;insight;Intervention;Knowledge;Link;Location;LoxP-flanked allele;Maintenance;Mammals;Mediating;Medical Care Costs;Metabolic;Metabolism;Microinjections;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;Molecular;mouse model;Mus;neural;neural circuit;Neurons;Neurotransmitters;Norepinephrine;novel;Operating Rooms;Patients;pediatric patients;pharmacologic;Play;pleiotropism;Population;Prevalence;Process;promoter;Proteins;Recovery;Recycling;Reporting;Research;response;Risk;Role;Synapses;Viral;Volatilization;Vulnerable Populations;Wakefulness;Work

PROJECT_TITLE: The role of astrocytes in emergence from volatile anesthetics

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences

ORG_DEPT: NEUROSCIENCES

PHR: Project Narrative: mRNA editing by RNA binding protein regulatory networks, increasingly associated with numerous neurodevelopmental disorders, greatly expand the complexity of the mammalian nervous system. These studies will employ state of the art bioinformatic analyses to identify protein-mRNA relationships important for generating neuronal cell types during development. These relationships will then be tested in a high-throughput in vitro system providing vital insight into the mechanisms underlying the hierarchical organization of cortical cell diversity.

PI_NAMEs: CAMPBELL, MELISSA MCKENZIE (contact)

PROGRAM_OFFICER_NAME: KISHORE, SANDEEP

PROJECT_TERMS: Address;Adoption;Adult;Alternative Splicing;Bioinformatics;Biology;Brain;cell cortex;Cell Separation;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;comparative;Complement;D Cells;Data Set;design;Development;Developmental Process;Embryo;Environment;experimental study;Fluorescence;Foundations;genetic regulatory protein;Health;In Vitro;in vivo;in vivo evaluation;insight;Interneurons;Knock-out;Knowledge;Medial;Messenger RNA;mRNA Precursor;Nervous System;neurodevelopment;Neurodevelopmental Disorder;Neurons;Output;Pattern;Process;Productivity;programs;Proteins;Publishing;Regulation;Reporter;Research;RNA analysis;RNA Editing;RNA Splicing;RNA-Binding Proteins;Rodent;Role;segregation;Signal Transduction;single-cell RNA sequencing;Somatostatin;Sorting;Specific qualifier value;stem cell biology;success;System;Testing;tool;Training;Transcript;Transcriptional Regulation;transcriptomics;Variant;Visual Cortex;WNT Signaling Pathway;Work

PROJECT_TITLE: mRNA Alternative Splicing Regulatory Networks in the Specification of Cortical Interneuron Subtypes

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: Opioid use disorders (OUDs) have been associated with a 4-fold increase in drug overdose deaths in the past decade, and current treatments including medications that block the opioid receptor require a withdrawal period during which time many patients relapse and tragically may overdose and die. This project will assess a new device, non-invasive Vagal Nerve Stimulation (nVNS), that does not require surgery or implantation, and that electrically stimulates the vagus nerve as it passes through the neck, dampening the sympathetic nervous system and modulating brain regions in a way that may help patients during the opioid withdrawal period and reduce relapse. Studying the effects of nVNS on opioid craving and brain and physiological responses in patients with OUDs has the potential to reduce relapse and save lives, as well as increase our knowledge of changes to the brain and physiology that underlie OUDs and successful response to treatment.

PI_NAMEs: BREMNER, JAMES DOUGLAS (contact);INAN, OMER TOLGA

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: Abstinence;addiction;Adverse reactions;analog;Anterior;Area;Binding;biological adaptation to stress;Brain;Brain region;Buprenorphine;Cardiac;Cardiovascular Physiology;Cardiovascular system;Cessation of life;Chest;craving;Cues;Data;Devices;Dopamine;Dose;drug craving;Drug Modulation;Drug usage;Electric Stimulation;Family;Health Services Accessibility;human subject;Imagery;implantation;Inflammation;Inflammatory;Inflammatory Response;Injectable;Interleukin-6;Intervention;Knowledge;Machine Learning;Measures;Medial;Methods;Modeling;Movement;Naltrexone;Neck;Nerve;neuroregulation;Norepinephrine;Nucleus Accumbens;Operative Surgical Procedures;Opiate Addiction;Opioid;Opioid agonist;Opioid Antagonist;Opioid Receptor;opioid use disorder;opioid withdrawal;Outcome;Outcomes Research;Overdose;overdose death;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phase;Photoplethysmography;Physiological;Physiology;Pilot Projects;Play;Positron;Positron-Emission Tomography;Post-Traumatic Stress Disorders;Prefrontal Cortex;Property;Radiolabeled;Randomized;Relapse;relapse patients;relapse risk;Resistance;Resolution;Respiration;response;response biomarker;Rewards;Role;Sampling;Stress;Sympathetic Nervous System;Symptoms;System;Technology;Time;tomography;transmission process;Trauma;treatment response;United States;vagus nerve stimulation;Vagus nerve structure;Validation;vasoconstriction;Vasomotor;Ventral Striatum;Visual;Water;wearable device;Withdrawal;Withdrawal Symptom

PROJECT_TITLE: Non-Invasive Vagal Nerve Stimulation in Patients with Opioid Use Disorders


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: OVERALL PROJECT NARRATIVE The Case Comprehensive Cancer Center is Northeast Ohio’s only NCI designated comprehensive cancer center providing bench-to-bedside medical research involving partnerships between basic, clinical and population scientists to speed translation of laboratory discoveries into new prevention/intervention and cancer  treatments.

PI_NAMEs: SCHWARTZ, GARY K (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: African American population;Ambulatory Care Facilities;anti-cancer research;Barrett Esophagus;Basic Cancer Research;Behavioral;bench to bedside;cancer care;Cancer Center;Cancer Center Support Grant;Cancer Detection;Cancer Patient;Cancer Research Infrastructure;cancer therapy;Caring;Catchment Area;Clinic;Clinical;clinical application;Clinical Research;Clinical Trials;Clinics and Hospitals;Collaborations;Colon Carcinoma;Communities;Community Outreach;Comprehensive Cancer Center;Decision Making;Dedications;Diagnosis;Disease;Dissemination and Implementation;drug discovery;Family;Focus Groups;Funding;General Population;Genetic Risk;Genomics;Goals;Grant;Growth;Health;high-throughput drug screening;Hospitals;Human;improved;Infrastructure;innovation;Institution;inter-institutional;Intervention;investigator-initiated translational research;Laboratories;Leadership;leukemia;Link;low socioeconomic status;Malignant Neoplasms;Medical Research;meetings;member;Mission;Molecular Abnormality;NCI-Designated Cancer Center;new therapeutic target;Newly Diagnosed;novel;Ohio;Patients;Population;Population Research;Prevention;programs;Protons;Quality of Care;Research;Research Activity;Research Personnel;Resource Sharing;Schools;Scientist;Site;Solid;Speed;Survivors;survivorship;Therapeutic;therapeutic target;Tobacco smoking behavior;Translational Research;Translations;Universities;University Hospitals;Update

PROJECT_TITLE: Case Comprehensive Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: POUNARDJIAN, JOHN  (contact)

PROJECT_TERMS: Administrative Personnel;Administrator;Affect;anti-cancer research;Applications Grants;Budgets;Businesses;Cancer Center Support Grant;cancer health disparity;Cancer Research Project;cancer stem cell;Clinic;Clinical Research;Clinics and Hospitals;Collaborations;Communication;Comprehensive Cancer Center;Computer software;Data;Decision Making;Dedications;Ensure;Equipment;Evaluation;Evaluation Research;Event;Financial Support;Funding;Funding Opportunities;Grant;Guidelines;improved;Institution;inter-institutional;Leadership;Link;Malignant Breast Neoplasm;Malignant Neoplasms;meetings;member;Mission;multidisciplinary;Newsletter;operation;Pharmaceutical Preparations;Philanthropic Fund;Policies;post-doctoral training;Process;programs;Publications;Reporting;Research;Research Personnel;resilience;Resource Sharing;Resources;Schedule;Schools;Services;software systems;statistics;Strategic Planning;Structure;success;symposium;System;Time Management;Training;Universities;University Hospitals;Update;Visit

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cancer

PI_NAMEs: JACKSON, MARK W. (contact)

PROJECT_TERMS: anti-cancer research;Basic Science;biomedical scientist;Cancer Center;Cancer Center Support Grant;cancer education;Cancer Science;career;career development;Career Mobility;Clinical;Clinical Oncology;Clinical Research;Clinical Sciences;clinical training;clinical trial protocol;Collaborations;Communication;Comprehensive Cancer Center;design;Education;education research;Enrollment;experience;Exposure to;Faculty;faculty mentor;Genomics;graduate student;Grant;Health Professional;Healthcare;high school;High School Student;human subject protection;improved;Individual;Institution;Institutional Review Boards;Laboratories;Malignant Neoplasms;Manuscripts;Medical Students;member;Mentors;Minority Groups;Monitor;multidisciplinary;NCI Center for Cancer Research;Peer Review;Physicians;Productivity;programs;Research;Research Personnel;Research Training;Scientist;Series;skill acquisition;summer research;Training;Training Activity;Training and Education;Training Programs;Travel;tumor;undergraduate student;Underrepresented Minority

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


ADMINISTERING_IC: AG

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: TUSCALOOSA

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

ORG_STATE: AL

PHR: This study will improve clinical outcomes for an important, growing, and vulnerable population— nursing home resident with Alzheimer’s disease or related dementias—by implementing an evidence-based intervention to improve these residents’ sleep. It will also significantly increase our understanding of how to implement and sustain nursing home interventions.

PI_NAMEs: HARTMANN, CHRISTINE W;SNOW, A LYNN (contact)

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: actigraphy;Activities of Daily Living;Address;Affect;Alzheimer's Disease;Alzheimer's disease related dementia;Analgesics;Assisted Living Facilities;Behavior;Bite;Caring;Clinical;clinical care;Collaborations;Communication;Consent;Data;data centers;Data Collection;decubitus ulcer;Dementia;design;Devices;effectiveness trial;Eligibility Determination;Emotional;Ensure;Evidence based intervention;fitbit;frailty;Frequencies;Frontline worker;Future;Goals;high risk;Hour;Hybrids;Impaired cognition;impression;improved;improved outcome;improvement on sleep;Incontinence;Individual;Infection Control;innovation;Inpatients;Intervention;intervention refinement;Knowledge;Learning;Light;Measures;meetings;Mental Health;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;Noise;nursing home length of stay;Nursing Homes;nursing intervention;older adult;Outcome;Pain;Pharmaceutical Preparations;Phase;pilot test;Polysomnography;pragmatic trial;primary outcome;Program Sustainability;programs;Protocols documentation;Quality of Care;Randomized, Controlled Trials;Recording of previous events;Relationship-Building;Research Methodology;Role;Safety;secondary outcome;Sleep;Sleep disturbances;sleep quality;Spottings;Standardization;success;systematic review;Testing;theories;Trainers Training;Training Programs;United States National Institutes of Health;Update;Variant;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Enhancing Sleep Quality for Nursing Home Residents with Dementia:  Pragmatic Trial


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Hematology;Orphan Drug;Rare Diseases

PI_NAMEs: SCHIEMANN, WILLIAM  (contact)

PROJECT_TERMS: Accounting;AML/MDS;Animal Experiments;Animal Model;Animals;biobank;Biomedical Research;Cancer Center Support Grant;Clinic;Collaborations;Collection;college;Complex;Comprehensive Cancer Center;Consent;Consultations;cost;CRISPR/Cas technology;Data;Development;Developmental Therapeutics Program;Doctor of Philosophy;Drug Kinetics;drug resistance development;Endometrial Carcinoma;Evolution;experimental study;Funding;Future;Genetic;genetic evolution;Genetic Models;Genetic Transcription;Genetically Engineered Mouse;Hematologic Neoplasms;Hematological Disease;Histologic;Human;humanized mouse;Immunodeficient Mouse;immunosuppressed;Immunotherapy;Individual;Institutional Review Boards;Investigational Drugs;Laboratories;Laboratory Personnel;Malignant neoplasm of ovary;Malignant Neoplasms;member;Messenger RNA;Methods;Mission;Modeling;Molecular Medicine;mouse model;Multiple Myeloma;Mus;Mutation;novel;novel drug combination;Oncology;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;Point Mutation;pre-clinical;preclinical evaluation;preclinical study;Principal Investigator;Procedures;professor;programs;Proteins;Protocols documentation;Research;Research Personnel;Research Project Grants;Resource Sharing;Ribonucleotide Reductase Inhibitor;service utilization;Services;Site;small molecule;Somatic Mutation;Source;Technical Expertise;Techniques;Technology Transfer;Testing;Therapeutic;Tissues;Training;Transgenic Organisms;Translational Research;tumor;Tumor Angiogenesis;Tumor Bank;tumor xenograft;Universities;Writing

PROJECT_TITLE: Athymic Animal and Preclinical Therapeutics Shared Resource


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Networking and Information Technology R&D (NITRD)

PI_NAMEs: DIAZ-INSUA, MIREYA  (contact)

PROJECT_TERMS: Adopted;Bioinformatics;Bioinformatics Shared Resource;bioinformatics tool;Biometry;Cancer Center Support Grant;Clinic;Clinical;Clinical Protocols;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Computational Biology;Computer software;Data;Data Analyses;data quality;Data Science;Data Set;data warehouse;Database Management Systems;Databases;design;Development;Doctor of Philosophy;Education;Ensure;Environment;Epidemiology;Experimental Designs;Formulation;Funding;Future;Grant;Hour;Human Resources;Informatics;Institution;Malignant Neoplasms;Manuscripts;Medicine;meetings;member;mid-career faculty;Mission;Modeling;Monitor;novel;operation;Peer Review;Pilot Projects;Process;Productivity;professor;programs;protocol development;Protocols documentation;Quality Control;Reporting;Research;Research Personnel;Research Project Grants;research study;Resources;response;Safety;Sample Size;Science;Secure;Services;Statistical Computing;Statistical Data Interpretation;success;Translational Research;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Shared Resource


PI_NAMEs: DESAI, AMAR  (contact)

PROJECT_TERMS: Accounting;Acoustics;Address;aged;anti-cancer research;Applications Grants;Appointment;Area;assay development;Automation;Biological Assay;Cancer Center Support Grant;cancer therapy;Case Management;Cell Cycle;Cell Death;Cell Separation;Cells;cellular imaging;Clinic;Clinical;Clinical Investigator;Clinical Trials;Communication;Comprehensive Cancer Center;Consult;Consultations;Cost Savings;Cytometry;data sharing networks;design;Development;Distant;drug discovery;Environmental Health;Equipment;Financial Support;Funding;Future;Glioma;Goals;Grant;Guidelines;Hypoxia;imaging facilities;Immunologic Monitoring;Immunophenotyping;instrument;Lasers;Malignant Neoplasms;Manufacturer;Measurement;medical schools;meetings;member;Microscope;Microscopy;Mission;Nature;Paper;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Play;Ploidies;programs;Proteins;Publishing;Radiation;Research;Research Assistant;Research Institute;Research Personnel;Research Support;Resource Sharing;response;Role;Safety;Science;Services;Shapes;Site;Specific qualifier value;success;Supporting Cell;Training;United States National Institutes of Health;Universities;University Hospitals;Validation

PROJECT_TITLE: Cytometry and Microscopy Shared Resource


PI_NAMEs: CAMERON, MARK JAMES (contact)

PROJECT_TERMS: Accounting;Adopted;Attention;Basic Science;Bioinformatics;Biological Assay;Cancer Center Support Grant;Cancer Research Project;Case Management;ChIP-seq;CLIA certified;Clinic;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Comprehensive Cancer Center;Computational Biology;Computer software;Consultations;cost effectiveness;Custom;Data;Data Analyses;data analysis pipeline;data integration;Development;Dideoxy Chain Termination DNA Sequencing;DNA;DNA analysis;Doctor of Philosophy;Ensure;Evaluation;exome;experience;Experimental Designs;Funding;Gene Expression;Gene Expression Profiling;Generations;Genetic;Genetic Transcription;genome sciences;Genomics;Genomics Shared Resource;Genotype;Individual;Informatics;Institution;Malignant Neoplasms;medical schools;member;Methylation;Microarray Analysis;microbiome analysis;mid-career faculty;Mission;Names;next generation sequencing;Nucleic Acids;Oncology;Phase;Preparation;programs;Published Comment;Quality Control;Research;Research Institute;Research Personnel;Research Project Grants;resource guides;Resources;RNA;RNA analysis;Sampling;Services;single cell genomics;Site;success;Technology;Time;Training;transcriptome sequencing;Translational Research;Universities;Validation;whole genome

PROJECT_TITLE: Integrated Genomics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology

PI_NAMEs: WALD, DAVID  (contact)

PROJECT_TERMS: Accounting;Basic Science;biobank;Biological Assay;Bioreactors;Blood;Blood Cell Count;Bone Marrow;bone marrow mesenchymal stem cell;Cancer Center Support Grant;Cancer Patient;cell preparation;Cell Separation;Cell Therapy;Cells;Cellular Assay;Clinical;clinical application;Clinical Protocols;clinical trial implementation;Clinical Trials;Color;Comprehensive Cancer Center;Consent;Consumption;cost effective;Data;demethylation;design;Development;Doctor of Philosophy;experience;Funding;good laboratory practice;Hematology;Hematopoietic;Hematopoietic Stem Cell Transplantation;Human;Human Resources;Individual;Infrastructure;Institutional Review Boards;interest;Investigational New Drug Application;manufacture;member;Mission;Natural Killer Cells;operation;Pathology;patient population;Patients;Phase;Phase I Clinical Trials;Population;pre-clinical;predictive marker;Preparation;Production;professor;programs;protocol development;Protocols documentation;Reagent;Regulation;Regulatory Pathway;Research;Research Personnel;research study;Resource Sharing;Resources;safety study;Sampling;scale up;Services;Source;standard of care;System;T-Lymphocyte;Technology;Therapy Clinical Trials;Time;Tissues;Training;Translational Research;Transplant Recipients;Umbilical cord structure

PROJECT_TITLE: Hematopoietic Biorepository and Cellular Therapy Shared Resource


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: This research will identify personalized genetic profiles of people at risk, protection, and resilience against AD/ADRD and vascular traits, the role of the AD/ADRD risk and other factors in these profiles, and new mechanistic links between genes, intermediate traits, and AD/ADRD and other diseases. These results have implications for identifying personalized interventions and natural (e.g., life style) factors helping to ameliorate or avoid AD/ADRD and other traits, and for development of personalized therapeutic

PI_NAMEs: KULMINSKI, ALEXANDER M;OUKRAINTSEVA, SVETLANA V.;YASHIN, ANATOLIY I (contact)

PROGRAM_OFFICER_NAME: RAGHAVACHARI, NALINI

PROJECT_TERMS: Address;Admixture;Affect;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Applications Grants;Bioinformatics;Biological;Biology;Birth;Blood Glucose;Blood Vessels;Body mass index;Brain;Cardiovascular Diseases;Cell Physiology;Cholesterol;cognitive performance;cohort;Complement;Complex;Data;dementia risk;density;Development;Disease;Education;Ensure;Environmental Exposure;Epigenetic Process;Ethnic Origin;Etiology;exome;exome sequencing;Fibrinogen;Gene Expression;Genes;Genetic;genetic association;genetic linkage analysis;Genetic Transcription;genetic variant;genome wide association study;Genotype;Haplotypes;Heterogeneity;High Density Lipoproteins;Hypertension;indexing;Individual;insight;Intervention;Life Style;Link;Linkage Disequilibrium;Lipids;lipoprotein cholesterol;Low-Density Lipoproteins;Measures;Mediation;Methods;Methylation;Molecular Analysis;Molecular Profiling;non-genetic;Non-Insulin-Dependent Diabetes Mellitus;novel;Onset of illness;Pathogenesis;Pathway interactions;Pattern;personalized intervention;personalized therapeutic;Persons;phenotypic data;Physiology;polygenic risk score;Populations at Risk;precision genetics;Predisposition;Proxy;Publications;Quantitative Trait Loci;Race;rare variant;Research;resilience;Risk;Role;sex;Signal Transduction;Smoking;social;Statistical Methods;statistics;Stroke;Structure;synergism;Tissues;trait;Triglycerides;United States National Institutes of Health;Variant;Vascular Diseases

PROJECT_TITLE: Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative This project will facilitate early detection of cognitive decline in older adults through development and implementation of an automated risk assessment and cognitive screening tool for use in primary care. By providing an automated tool developed specifically to address the needs of PCPs, it will be easier to screen for cognitive impairment, increasing the number of older adults who are screened and thus identified and treated.

PI_NAMEs: CHANG, JOSHUA TSUKANG (contact);HILSABECK, ROBIN C

PROJECT_TERMS: Address;Age;Alzheimer disease detection;Alzheimer's Disease;Assessment tool;Attention;Benefits and Risks;Blood Pressure;Caring;Cholesterol;Cognition;Cognitive;cognitive ability;cognitive performance;cognitive testing;Communication;cost;Dementia;dementia risk;Development;Diagnosis;Disease;Early Diagnosis;Early identification;Education;effectiveness testing;Electronic Health Record;electronic health record system;Ethnic Origin;experience;Face;Goals;Health Professional;high risk;Impaired cognition;indexing;Individual;Instruction;Intervention;Knowledge;Label;Measurement;Measures;Medical;Medicare;Memory;Methods;mild cognitive impairment;older adult;Participant;patient population;Patients;Persons;Phase;pilot test;Play;Population;pressure;prevent;Preventive healthcare;Primary Care;primary care clinic;primary care provider;primary care setting;Procedures;Process;processing speed;Race;Recommendation;Reporting;Research;Risk Assessment;Role;Sampling;screening;Screening procedure;Short-Term Memory;skills;Speech;Testing;Thinking;Time;tool;United States;usability;Validation;Voice;wellness visit;Work

PROJECT_TITLE: Cognitive Screening Made Easy for Primary Care Providers


PI_NAMEs: FLASK, CHRISTOPHER A (contact)

PROJECT_TERMS: Accounting;Adult;Animal Cancer Model;Animal Housing;anti-cancer research;Applications Grants;Basic Science;Bioluminescence;Biomedical Engineering;Cancer Center Support Grant;cancer imaging;cancer initiation;Cancer Patient;Cancer Research Project;Caring;Cells;Childhood;Clinic;Clinical;clinical imaging;Clinical Research;Communication;Comprehensive Cancer Center;cost effective;Cyclotrons;Dedications;design;Doctor of Philosophy;experimental study;Fingerprint;flasks;Fluorescence;Funding;Goals;Human;Image;Image Analysis;imaging capabilities;imaging facilities;imaging system;improved;in situ imaging;in vivo;Individual;Infrastructure;Institution;instrumentation;Journals;Magnetic Resonance Imaging;Malignant Neoplasms;Medical center;member;Methodology;mid-career faculty;Mission;Nanotechnology;Nature;NCI Center for Cancer Research;novel;novel therapeutic intervention;operation;Pathway interactions;Patients;Pediatrics;Positron-Emission Tomography;pre-clinical;pre-clinical research;preclinical imaging;programs;Publications;quantitative imaging;Radiochemistry;Radiology Specialty;radiotracer;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Screening for cancer;Services;Site;Technology;Training;tumor progression;United States National Institutes of Health;Universities;University Hospitals

PROJECT_TITLE: Imaging Research Shared Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

PI_NAMEs: COUCE, MARTA  (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;anti-cancer research;Area;behavior measurement;Biological Models;Cancer Burden;Cancer Center Support Grant;Cancer Control;cancer health disparity;cancer prevention;cancer risk;Catchment Area;Cohort Studies;Collaborations;Communities;community intervention;community organizations;community partnership;community research;comorbidity;Complex;Comprehensive Cancer Center;Data;Data Collection;data infrastructure;Database Management Systems;Databases;Development;Doctor of Philosophy;Economics;Evaluation;Funding;health care service organization;Healthcare Systems;implementation intervention;improved;Individual;information framework;Infrastructure;Intervention;Intervention Studies;Investments;Link;Malignant Neoplasms;Measures;member;Methodology;Methods;models and simulation;NCI Center for Cancer Research;Neighborhoods;neoplasm registry;novel;Observational Study;Ohio;Outcome;Outcome Measure;Outcomes Research;Participant;Patient Outcomes Assessments;Persons;Phase;population based;population health;Population Research;practice-based research network;programs;Public Health;Qualitative Methods;Research;Research Design;Research Personnel;Research Support;Resource Sharing;Risk Factors;Services;Siccoral;Site;social;social health determinants;therapy design;therapy development;Transcend

PROJECT_TITLE: Multimethod Cancer Outcomes Research Shared Resource


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE: Temporal lobe epilepsy (TLE) is a seizure disorder often with devastating effects, particularly in the large number of patients for whom current treatments are ineffective. The proposed research will capitalize on the use of the first CNS infection-induced mouse model of TLE developed, by our group, to perform state of the art in vivo and in vitro 2-photon imaging experiments using our innovative genetically encoded calcium indicating protein toolkit. In addition, transgenic mice will be employed to study TLE in interacting networks of neurons and microglial cells during the process of epileptogenesis to test the hypothesis that tumor necrosis alpha signaling from microglia to neurons contributes to seizure generation following CNS infection.

PI_NAMEs: WILCOX, KAREN S (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Acute;acute infection;Animal Model;Award;Brain;C57BL/6 Mouse;Calcium;Cell Death;Central Nervous System Infections;Central Nervous System Viral Diseases;Chronic;cytokine;Cytokine Receptors;Data;Development;Electroencephalography;Electrophysiology (science);Epilepsy;Epileptogenesis;experimental study;Generations;Goals;Hippocampus;Image;Immune;In Vitro;in vivo;ineffective therapies;Infection;Infection prevention;Injections;innovation;insight;interdisciplinary approach;Knock-out;Microglia;Monitor;Motility;mouse model;Mus;Necrosis;Neurons;novel;novel therapeutic intervention;Pathologic;Pathway interactions;Patients;Process;Production;Proteins;receptor;Recurrence;Reporting;Research;Risk;Role;Seizures;selective expression;Signal Transduction;Slice;Status Epilepticus;Synaptic Transmission;System;Temporal Lobe Epilepsy;Testing;Time;TMEV;TNF gene;Transgenic Mice;tumor;two photon microscopy;two-photon;Viral;Virus Diseases

PROJECT_TITLE: Javits Award Final Three Years


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PI_NAMEs: MARUYAMA, JUNKI  (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Acute;Address;Africa;African;Amino Acids;Animal Model;Annual Reports;Arenavirus;Arenavirus Infections;Basic Science;Biological;Biological Containment;biosafety level 4 facility;Blood;Case Fatality Rates;Cavia;Classification;Clinical;Clinical Chemistry;Clinical Data;Containment;cost;Country;Data;Development;Disease;Disease Outbreaks;experimental study;Family member;Functional disorder;Goals;Guinea;guinea pig model;Hematology;Hemorrhage;Histopathology;hospitalization rates;Human;Immune response;Immunocompetent;Immunologics;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Infection;insight;Integration Host Factors;Laboratories;Lassa Fever;Lassa virus;Liberia;Methods;Modeling;Molecular;Molecular Biology;Nigeria;nonhuman primate;novel;pathogen;Pathogenesis;pathogenic virus;Pathogenicity;Pathologic;Patients;Phase;Phenotype;Populations at Risk;Preventive;Proteins;Public Health;Recombinants;Research;research and development;reverse genetics;Risk;RNA-Directed RNA Polymerase;Rodent Model;Safety;Sensorineural Hearing Loss;Sierra Leone;System;Techniques;Therapeutic;tool;Vaccines;Viral;Viral Genome;Viral Pathogenesis;Viral Proteins;Virulence;Virulence Factors;Virus;Virus Diseases

PROJECT_TITLE: Viral factors responsible for Lassa virus pathogenicity


NIH_SPENDING_CATS: Biotechnology;Cancer

PI_NAMEs: CHANCE, MARK R (contact)

PROJECT_TERMS: Accounting;anti-cancer research;Applications Grants;Award;Bioinformatics;bioinformatics resource;bioinformatics tool;Biological;Budgets;Cancer Center Support Grant;cancer genetics;cancer pharmacology;Case Management;Cells;Clinic;Clinical;clinical investigation;Communication;Complement;Comprehensive Cancer Center;computing resources;Consultations;Data Analyses;data integration;Data Set;Dedications;Developmental Therapeutics Program;Doctor of Philosophy;Drug Kinetics;Equipment;Experimental Designs;experimental study;Funding;Grant;Human Resources;imaging system;Institution;instrument;investigator training;Journals;lipidomics;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Manuscripts;Medical;medical schools;member;metabolomics;Mission;Molecular Medicine;molecular oncology;Nature;NCI Center for Cancer Research;new technology;nutrition;Paper;Pathway interactions;phosphoproteomics;Professional Education;professor;programs;Proteomics;Proteomics Shared Resource;Publishing;Research;Research Institute;Research Personnel;Resource Sharing;Resources;Science;Services;Site;small molecule;structural biology;System;Systems Biology;Techniques;Technology;tool;Training;Universities

PROJECT_TITLE: Proteomics Shared Resource


NIH_SPENDING_CATS: Cancer;Radiation Oncology

PI_NAMEs: MUZIC, RAYMOND F (contact)

PROJECT_TERMS: Acceleration;Accounting;Animal Experimentation;Animal Experiments;Animals;Apoptotic;base;Biological Assay;Biology;Blood;Bone Marrow;Bone Marrow Ablation;Bone Marrow Transplantation;Calibration;Cancer Biology;Cancer Center Support Grant;cancer genetics;Cells;Clinical;clinical implementation;clinical investigation;Clinical Treatment;Colon;Comprehensive Cancer Center;Consultations;cost;design;Development;Developmental Therapeutics Program;Devices;DNA Damage;Doctor of Philosophy;Equipment;Experimental Designs;experimental study;Funding;G22P1 gene;Gamma Knife Radiosurgery;Goals;Hematopoiesis;Hematopoietic;homologous recombination;human stem cells;Immune;Individual;Institution;instrumentation;interest;Investigation;Ionizing radiation;irradiation;Laboratories;Liver;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Mediator;member;Methods;Mission;Modeling;molecular oncology;new technology;Nonhomologous DNA End Joining;novel;novel therapeutics;oncology program;operation;Phenotype;pre-clinical;Pre-Clinical Model;professor;programs;Property;proton therapy;Protons;Publications;Publishing;Radiation;Radiation Oncology;Radiation therapy;Radiobiology;Radiology Specialty;Radiosurgery;Recovery;regeneration potential;Regulation;repaired;Research;Research Personnel;Resource Sharing;Resources;Sampling;Science;Security;Services;Source;Sterilization;System;Technology;tissue injury;tool;Training;Universities;University Hospitals

PROJECT_TITLE: Radiation Resources Shared Resource


PI_NAMEs: ADAMS, DREW JAMES (contact)

PROJECT_TERMS: Accounting;Address;Applications Grants;assay development;Automation;Biological Assay;Biotechnology;Cancer Center Support Grant;cheminformatics;Clinic;Collaborations;Comprehensive Cancer Center;Consultations;cost;Data;design;Doctor of Philosophy;drug development;Drug Utilization;Equipment;Extramural Activities;Future;Genetic;genome sciences;high throughput screening;In Vitro;in vivo;in vivo evaluation;Infrastructure;innovation;instrument;interest;Lead;Libraries;Link;Malignant Neoplasms;Manuscripts;Medicine;member;Mission;operation;Pathway interactions;Pharmaceutical Chemistry;Pharmacology;professor;programs;Proteomics;Recommendation;Research;Research Personnel;Resource Sharing;Scientist;screening;screening services;small molecule;small molecule libraries;Therapeutic;Training;Universities;University Hospitals;Work

PROJECT_TITLE: Small Molecule Drug Development Shared Resource


PROJECT_TERMS: Accounting;Animal Experimentation;animal tissue;animation;anti-cancer research;Area;Basic Science;biobank;Bioinformatics;Biology;Breast;Cancer Center;Cancer Center Support Grant;cancer genetics;cancer imaging;cancer prevention;Catchment Area;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Trials;Collaborations;Collection;Comprehensive Cancer Center;Computer software;Consult;Consultations;cost effective;CRISPR/Cas technology;Cryopreservation;Data;Databases;Derivation procedure;design;Development;Disease;Dissection;Doctor of Philosophy;Ensure;Evolution;experimental study;Fertilization in Vitro;follow-up;Funding;Gene Targeting;Genes;Genetic Models;genetic variant;Genitourinary system;Goals;Heterogeneity;Histology;Human;human model;Human Resources;human tissue;Immunohistochemistry;Immunologic Monitoring;Immunotherapy;improved;In Situ Hybridization;in vivo imaging;Institution;Knock-in Mouse;Knock-out;Link;Lung;Malignant neoplasm of central nervous system;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Melanoma;member;Methods;migration;Missense Mutation;Mission;Molecular Medicine;mouse genetics;mouse model;Mus;Mutation;NCI Center for Cancer Research;Operative Surgical Procedures;Ophthalmology;Pathology;patient population;Patients;Play;Policies;Population Research;Preparation;Procedures;professor;programs;Protocols documentation;Research;Research Personnel;Resource Sharing;Resources;Role;sample collection;Sampling;Sarcoma;Secure;Services;Solid Neoplasm;Specimen;Standardization;success;Susceptibility Gene;Technology;Tissue Banks;Tissue Microarray;Tissue Procurements;tissue resource;Tissue Sample;Tissues;Training and Education;Transgenic Organisms;University Hospitals;web site

PROJECT_TITLE: Tissue Resources Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics

PI_NAMEs: CONLON, RONALD A. (contact)

PROJECT_TERMS: Accounting;Adopted;animation;anti-cancer research;Area;Biology;Cancer Center;Cancer Center Support Grant;cancer imaging;Cancer Model;cancer type;Comprehensive Cancer Center;Consult;Consultations;cost effective;CRISPR/Cas technology;Cryopreservation;Derivation procedure;Disease;Doctor of Philosophy;Ensure;Evolution;Fertilization in Vitro;follow-up;Funding;Gene Targeting;Genes;Genetic;Genetic Models;genetic variant;genome sciences;Goals;Human;human model;humanized mouse;improved;in vivo imaging;Institution;Investigation;Knock-in Mouse;Knock-out;Malignant Neoplasms;member;Methods;mid-career faculty;Missense Mutation;mouse genetics;mouse model;Mus;Mutation;NCI Center for Cancer Research;new technology;Operative Surgical Procedures;Play;programs;Research;Research Personnel;Research Project Grants;Resource Sharing;Role;Services;skills;success;Susceptibility Gene;Technology;Training and Education;Transgenic Organisms;web site

PROJECT_TITLE: Transgenic and Targeting Shared Resource


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Orphan Drug;Rare Diseases

PI_NAMEs: PINK, JOHN J (contact)

PROJECT_TERMS: 3-Dimensional;Accounting;base;Biological Assay;Blood;Brain Neoplasms;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer risk;Cancer Therapy Evaluation Program;career development;Cell Culture Techniques;Cell Cycle;Cells;Classification;Clinic;Clinical Cancer Center;Clinical Investigator;Clinical Research;Clinical Trials;Coculture Techniques;Comprehensive Cancer Center;Consultations;cost effective;Data;design;Developmental Therapeutics Program;DNA;Doctor of Philosophy;Drug Combinations;Drug Design;drug development;drug discovery;drug testing;experimental study;Formalin;Freezing;Funding;Genomics;Glioma;Hematopoietic;Immune;In Vitro;in vivo evaluation;Individual;Laboratories;Laboratory Study;Logistics;Malignant Neoplasms;member;Mentored Clinical Scientist Development Program;Methods;methoxyamine;Modeling;Molecular Medicine;Monitor;New Agents;novel;novel drug combination;Oncology;Patients;Pemetrexed;Phase;phase 2 study;Phase I Clinical Trials;pre-clinical;Pre-Clinical Model;Preclinical Drug Development;Primary Neoplasm;professor;prognostic;Program Development;programs;protein expression;Publications;Radiation;Research;Research Personnel;Resource Sharing;Resources;Role;Sampling;Services;Site;Specimen;Testing;The Cancer Genome Atlas;Therapeutic;tissue preparation;Tissues;Translational Research;treatment response;Universities;University Hospitals

PROJECT_TITLE: Translational Research Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Orphan Drug;Precision Medicine;Prevention;Rare Diseases

PI_NAMEs: WANG, ZHENGHE  (contact)

PROJECT_TERMS: Aberrant DNA Methylation;Address;Adoption;African American population;anti-cancer research;Aspirin;Award;Barrett Esophagus;Big Data;bioinformatics tool;biomarker driven;Biometry;cancer cell;Cancer Center;Cancer Center Support Grant;cancer chemoprevention;Cancer Detection;cancer genetics;Cancer Patient;cancer therapy;carcinogenesis;causal variant;Chromatin;Clinical;clinical development;clinical implementation;Clinical Research;Clinical Trials;cohort;Collaborations;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;colorectal cancer screening;Comprehensive Cancer Center;Detection;Development;Diagnosis;Direct Costs;Disparity;DNA;DNA Methylation;drug response prediction;Drug usage;early detection biomarkers;Early Detection Research Network;Early Diagnosis;early phase clinical trial;Epidemiology;epigenetic marker;Epigenetic Process;epigenome;Esophageal Adenocarcinoma;Esophageal Neoplasms;Esophagus;Ethnic Origin;Faculty;Feces;Follow-Up Studies;Foundations;Funding;gene environment interaction;Gene Mutation;Genetic;Genetic Research;genome editing;Genomics;Germ-Line Mutation;Goals;Grant;Health Professional;in vivo Model;Individual;innovation;interest;invention;Leadership;Malignant neoplasm of esophagus;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant phenotype;member;Methods;Modeling;mutant;Mutation;National Cancer Advisory Board;new therapeutic target;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Nurses' Health Study;Organoids;Pathway interactions;Peer Review;personalized biomarkers;Phase II Clinical Trials;PIK3CG gene;pre-clinical research;predictive marker;Predisposition;Prevention;Prognosis;Program Research Project Grants;programs;Proteomics;Protocols documentation;Publications;Publishing;Race;racial disparity;Recommendation;recruit;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Role;Science;screening;small molecule inhibitor;stem cells;success;Systems Biology;Technology;therapeutic development;therapeutic target;tissue resource;Translating;Tumor Suppressor Proteins;United States Preventative Services Task Force;Validation;Work;working group

PROJECT_TITLE: GI Cancer Genetics Research Program


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Obesity;Prevention;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PI_NAMEs: LATHIA, JUSTIN D. (contact)

PROJECT_TERMS: 26S proteasome;Acceleration;Address;angiogenesis;anti-cancer research;Award;Basic Science;Biometry;Blood Vessels;Brain Neoplasms;Breast;cancer cell;Cancer Center;Cancer Center Support Grant;Cancer Control;cancer genetics;cancer imaging;cancer prevention;cancer stem cell;cancer therapy;catalyst;Catchment Area;cell motility;Cell Proliferation;Cell secretion;cell type;Cell-Matrix Junction;Cells;Clinical;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Cytometry;Defect;Development;Devices;Direct Costs;Disease;DNA Damage;DNA Repair;Down-Regulation;Drug resistance;fatty acid metabolism;Funding;Gene Expression Regulation;Genetic Recombination;Genomic Instability;Glioblastoma;Glioma;Goals;Grant;Head and Neck Cancer;Home;host neoplasm interaction;Hyperthermia;Image;Immune Evasion;Incubators;Integrins;interest;Invaded;Investigation;Iron;Journals;Kinesin;Leadership;macromolecule;Maintenance;Malignant Breast Neoplasm;Malignant neoplasm of gastrointestinal tract;Malignant Neoplasms;Meiosis;member;Mitotic;Molecular;molecular oncology;multicatalytic endopeptidase complex;Mus;Nature;neoplastic cell;Normal Cell;novel;novel strategies;novel therapeutics;Obesity;Obesity associated cancer;oncology program;Pathway interactions;Peer Review;Pericytes;periostin;Phenotype;Population;Population Research;pre-clinical research;precision medicine;Prevalence;Productivity;Program Research Project Grants;programs;Proliferating;Proteins;Proteomics;Protocols documentation;Publications;Publishing;Radiation-Sensitizing Agents;Radiosensitization;recruit;Regulation;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;response;Role;Schedule;Science;Scientist;self-renewal;Signal Transduction;stem cell biology;Stem Cell Development;stem cells;stem-like cell;symposium;therapy resistant;tissue resource;TLR4 gene;trafficking;transdifferentiation;translational cancer research;Translations;treatment response;tumor;Tumor Cell Invasion;tumor growth;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor-associated macrophages;tumorigenesis;tumorigenic;Vertebral column;working group

PROJECT_TITLE: Molecular Oncology Research Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Vaccine Related

PI_NAMEs: HUNG, ALEX  (contact)

PROJECT_TERMS: Adjuvant;Adult;Advisory Committees;Aging;anti-cancer;Antigens;Architecture;Area;Biological;Biometry;blood neoplasm;Cancer Biology;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer immunotherapeutics;Cancer Patient;cancer therapy;Caring;Cell Therapy;Cellular Immunity;Cellular immunotherapy;Clinical;clinical application;Clinical Research;Clinical Trials;Collaborations;Comprehensive Cancer Center;Consensus;Cytometry;demethylation;Dendritic Cell Vaccine;Dendritic Cells;design;Development;Developmental Therapeutics Program;Diagnosis;Direct Costs;Disease;disease classification;DNA Sequence Alteration;drug discovery;Elderly;Engineering;Epigenetic Process;Evolution;Failure;Funding;Future;Generations;Genes;Genetic;Genomics;Genotype;Germ Lines;Grant;Health;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Immune;Immune Evasion;Immune response;Immunologic Surveillance;immunoreactivity;Immunotherapy;improved;improved outcome;innovation;Institution;International;Investments;Lead;Leadership;leukemia;lymphoid neoplasm;Lymphoma;Malignant Neoplasms;Marrow;Mediating;member;Molecular;Molecular Target;Multiple Myeloma;mutation screening;Myelogenous;Myeloid-derived suppressor cells;Myeloproliferative disease;Names;Natural Killer Cells;Neoplasms;neoplastic cell;new therapeutic target;novel;novel therapeutics;Pathogenesis;Pathway interactions;Peer Review;personalized medicine;pharmacologic;Population;pre-clinical research;Process;prognostication;Program Research Project Grants;programs;Property;Protocols documentation;Publications;Publishing;Refractory;Regimen;Relapse;Research;Research Personnel;Resource Sharing;Role;Solid Neoplasm;Southwest Oncology Group;Stem cell transplant;Syndrome;T-Lymphocyte;targeted treatment;Therapeutic;Tissues;Transgenic Organisms;Translational Research;tumor;Tumor Escape;Vaccines;working group

PROJECT_TITLE: Hematopoietic and Immune Cancer Biology Research Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PI_NAMEs: LETTERIO, JOHN JAMES (contact)

PROJECT_TERMS: Address;advanced breast cancer;Advanced Malignant Neoplasm;AML/MDS;analog;anticancer activity;Apoptosis;ATP phosphohydrolase;Azacitidine;Back;Base Excision Repairs;BCL2 gene;BH4 Domain;Biological Markers;Biotechnology;Brain;Breast;Cancer Biology;cancer cell;Cancer Center;Cancer Center Support Grant;cancer drug resistance;cancer genetics;cancer immunotherapy;Cancer Patient;Cancer Therapy Evaluation Program;Catchment Area;Clinical;clinical development;Clinical Research;Clinical Trials;Collaborations;Colon;combinatorial;Comprehensive Cancer Center;Creativeness;Cytometry;Decitabine;Development;Developmental Therapeutics Program;Differentiation Therapy;Direct Costs;Disease;DNA Repair;DNA Repair Inhibition;drug development;drug discovery;Drug Kinetics;Drug resistance;Drug resistance pathway;Drug usage;early phase clinical trial;early phase trial;Effectiveness;Epidermal Growth Factor Receptor;Epigenetic Process;first-in-human;forging;Funding;Gene Mutation;Genetic;Genetic Markers;Genomics;glycogen synthase kinase 3 beta inhibitor;Goals;Grant;Growth;Hematopoietic;Image;Immune;immune checkpoint;improved;inhibitor;Laboratories;Leadership;Link;Malate Dehydrogenase;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;member;Mentors;methoxyamine;molecular marker;molecular targeted therapies;Mutation;New Agents;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel strategies;novel therapeutics;nucleoside analog;nucleotide metabolism;Oral;Outcome;Ovary;Oxidoreductase;Pancreas;Pathway interactions;patient derived xenograft model;Peer Review;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase II trial;pre-clinical;pre-clinical assessment;pre-clinical research;preclinical development;preclinical study;Program Research Project Grants;programs;Protein Phosphatase 2A Regulatory Subunit PR53;Proteomics;Protocols documentation;Publications;Publishing;pyrimidine metabolism;Radiation;Relapse;Research Personnel;Research Project Grants;Resistance;Resource Sharing;response;RNA Splicing;Role;Sampling;Scientist;Series;small cell lung carcinoma;SMARCA5 gene;Solid Neoplasm;System;Tetrahydrouridine;Therapeutic;Therapeutic Research;TP53 gene;TP53-mutant acute myeloid leukemia;Training;Transforming Growth Factor beta;tumor;Tumor Escape;Uracil;Validation;Work;working group

PROJECT_TITLE: Developmental Therapeutics Research Program


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Brain Cancer;Brain Disorders;Breast Cancer;Cancer;Nanotechnology;Orphan Drug;Prevention;Rare Diseases;Women's Health Research

PI_NAMEs: BASILION, JAMES PETER (contact)

PROJECT_TERMS: Animals;Area;attenuation;Automobile Driving;Biology;Biometry;Brain Neoplasms;Breast Cancer Detection;Cancer Biology;Cancer Center;Cancer Center Support Grant;Cancer Detection;cancer imaging;cancer prevention;cancer therapy;Canis familiaris;Chemistry;Clinical;clinical diagnosis;clinical investigation;Clinical Investigator;clinical prognosis;Clinical Research;Clinical Trials;Collaborations;Communication;Comprehensive Cancer Center;computerized tools;Cytometry;Data;design;Detection;Development;Developmental Therapeutics Program;Diagnostic;digital pathology;Direct Costs;Engineering;Evaluation;Fibronectins;Fingerprint;Fostering;Foundations;Funding;Generations;Goals;Hematopoietic;ideation;Image;imaging agent;imaging detection;imaging modality;imaging program;imaging scientist;Immune;improved;in vivo imaging;innovation;Institution;interdisciplinary collaboration;interest;International;invention;Leadership;Machine Learning;Magnetic Resonance Imaging;Magnetism;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;man;Medicine;meetings;Melanoma;member;Metastatic malignant neoplasm to brain;Methodology;Micrometastasis;Microscopic;molecular oncology;multimodality;Mus;nano;nanomedicine;nanoparticle;Nature;NCI-Designated Cancer Center;neuroimaging;new technology;new therapeutic target;novel;novel imaging technology;Oncologist;optical imaging;particle;Pathogenesis;Pathologic;Pathologist;Patient Care;Patients;Peer Review;Physicians;Physics;Plants;Population Research;Positron-Emission Tomography;Program Research Project Grants;programs;Publications;Publishing;radiologist;radiomics;recruit;Research;Research Personnel;Research Project Grants;Resource Sharing;Scientist;Specimen;targeted agent;targeted treatment;Technology;Therapeutic;Three-Dimensional Imaging;tool;Toy;Translating;translational research program;treatment response;tumor;Tumor Pathology;Ultrasonography;ultrasound;Viral;Visualization;Work;working group

PROJECT_TITLE: Cancer Imaging Research Program


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Palliative Care;Prevention;Social Determinants of Health;Tobacco;Tobacco Smoke and Health;Women's Health Research

PI_NAMEs: COOPER, GREGORY S. (contact)

PROJECT_TERMS: 21 year old;Adopted;Advanced Malignant Neoplasm;Affordable Care Act;American Society of Clinical Oncology;anti-cancer research;Attention;Award;Behavior Therapy;Behavioral Medicine;beneficiary;Biometry;Breast Cancer therapy;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer diagnosis;cancer epidemiology;Cancer Patient;cancer prevention;Cancer Prognosis;cancer risk;Caring;Catchment Area;chemotherapy;Cigar;Cities;Clinical;clinical practice;Clinical Practice Guideline;Clinical Trials;Collaborations;colon cancer screening;Communities;Comprehensive Cancer Center;data resource;Data Sources;Databases;Death Certificates;Direct Costs;Disparity;Early Diagnosis;Economics;Education;Environmental Risk Factor;epidemiology study;Funding;Future;Genetic;Genomics;Goals;Goserelin;Grant;Health;Health Care Reform;Health Policy;Health Services Research;Healthcare Systems;High Prevalence;HIV;improved;improved outcome;Incidence;Individual;Intervention;Laws;Leadership;Link;Malignant neoplasm of prostate;Malignant Neoplasms;Mammography;Medicare;member;Methods;Monitor;Multiomic Data;National Comprehensive Cancer Network;Neighborhoods;neoplasm registry;Nicotine;novel;novel strategies;Ohio;Online Systems;Outcome;ovarian failure;Palliative Care;Patient Care;Peer Review;Policies;Population;population health;Population Research;Population Study;prediction algorithm;Prevention;Prevention strategy;Preventive service;Primary Prevention;Program Research Project Grants;programs;Public Health;Publications;Publishing;Quality of Care;Recommendation;Research;Research Personnel;Resource Sharing;Risk Reduction;Sales;screening;Screening for cancer;smoking cessation;smoking intervention;social;success;survivorship;synergism;Text;Tissues;Tobacco;tobacco control;tobacco products;Tobacco Use Cessation;Underserved Population;uptake;Urban Population;urban underserved;Work;working group;Youth

PROJECT_TITLE: Cancer Prevention, Control, and Population Research Program


NIH_SPENDING_CATS: Biotechnology;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: SCHWARTZ, GARY K (contact)

PROJECT_TERMS: Advisory Committees;Articulation;Atlases;Award;Bioinformatics;Cancer Center;Cancer Center Support Grant;cancer prevention;cancer type;career;Catchment Area;CDK5 gene;Cell Therapy;Clinical;clinical translation;Clinical Trials;Comprehensive Cancer Center;cytokine;Database Management Systems;Detection;Discipline;Disease;Disparity;Drug Monitoring;Drug resistance;Drug Targeting;Early Diagnosis;early phase trial;Elements;Etiology;Evaluation;Future;Genomics;Goals;Guidelines;Human;imaging modality;immune checkpoint;Immunology;immunoregulation;Immunotherapeutic agent;improved;Institution;inter-institutional;Interleukin-15;Investigation;Investments;Lead;Leadership;Malignant Breast Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;Mentors;metabolomics;Mission;Modeling;nanotherapeutic;Natural Killer Cells;Neoplasm Metastasis;novel therapeutics;Organoids;particle;Pathway interactions;Periodicals;Pharmacotherapy;Population;population based;pre-clinical;premalignant;Prevention Research;Prognosis;programs;Radiation;recruit;Research;Research Personnel;Resistance;Resource Sharing;Sampling;screening;small molecule therapeutics;Strategic Planning;Structure;survivorship;T-Lymphocyte;Therapeutic;Training;Transforming Growth Factor beta;treatment response;tumor;Underrepresented Populations;Underserved Population;Update;Viral

PROJECT_TITLE: Leadership, Planning, and Evaluation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

PI_NAMEs: TRAPL, ERIKA S (contact)

PROJECT_TERMS: access disparities;Address;African American;African American population;anti-cancer research;Award;Awareness;Breast Cancer survivor;Cancer Burden;Cancer Center Support Grant;Cancer Etiology;cancer genetics;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Catchment Area;Censuses;Cities;Clinical Trials;Collaborations;Colon Carcinoma;colorectal cancer screening;Communities;community advisory board;community center;community engaged intervention;community engaged research;community engagement;Community Outreach;Community Surveys;Comprehensive Cancer Center;County;Data;data registry;Disparity;disparity reduction;Early Diagnosis;Environment;ethnic minority population;Ethnic Origin;Faculty;Fostering;Funding;Goals;health assessment;health equity;Hispanic Populations;Hospitals;Human Papillomavirus;Individual;Information Systems;innovation;Interdisciplinary Study;interest;Intervention;Knowledge;Local Government;low socioeconomic status;Malignant neoplasm of gastrointestinal tract;Malignant neoplasm of lung;Malignant Neoplasms;Maps;medically underserved;member;Methods;Minority;Mutation;Neighborhoods;Nonprofit Organizations;Ohio;Outcome;outreach;outreach program;patient navigation;Physical activity;Population;population based;population health;Poverty;Primary Prevention;Process;Program Evaluation;programs;provider networks;quitline;Race;racial disparity;racial minority population;recruit;Research;Research Personnel;Risk Factors;Role;safety net;Scientific Inquiry;Services;Site;socioeconomic disparity;System;Targeted Research;tertiary prevention;Testing;Tobacco;Tobacco 21 policies;Training Programs;Translating;underserved community;underserved minority;Work

PROJECT_TITLE: Community Outreach and Engagement


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention

PROJECT_TERMS: anti-cancer research;Award;Cancer Center;Cancer Center Support Grant;Cancer Etiology;cancer health disparity;cancer prevention;cancer research center director;Clinical;clinical investigation;Clinical Investigator;Clinical Trials;Comprehensive Cancer Center;Detection;Development;Developmental Therapeutics Program;Discipline;drug development;Emerging Technologies;Endowment;Funding;Grant;Immunologic Monitoring;Infrastructure;innovation;Institution;Investments;Measures;Phase;Pilot Projects;Population Research;Prevention;programs;Publications;recruit;Research;Research Personnel;Resource Sharing;Resources;single cell analysis;small molecule;Speed;Strategic Planning;Therapeutic;Universities

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Social Determinants of Health

PI_NAMEs: GERDS, AARON THOMAS (contact)

PROJECT_TERMS: Address;Age;Biopsy;Budgets;Cancer Center Support Grant;Cancer Patient;Cancer Survivor;Child;clinical care;Clinical Data;Clinical Investigator;Clinical Management;Clinical Protocols;Clinical Research;Clinical Trials;Clinical Trials Support Unit;Comprehensive Cancer Center;Conduct Clinical Trials;Contracts;Data;data integrity;data management;Databases;Development;Diagnosis;Education;Enrollment;Ensure;Ethnic Origin;Gender;Goals;Healthcare Systems;improved;Infrastructure;insight;Institution;Intervention;Intervention Studies;Intervention Trial;investigator-initiated trial;Laboratories;Malignant Childhood Neoplasm;Malignant Neoplasms;Monitor;National Clinical Trials Network;Nursing Research;Outcome;patient safety;Patients;Peer Review;Policies;prevent;Procedures;Protocols documentation;Provider;quality assurance;Race;Reporting;Research;Research Personnel;research study;Resources;Safety;Services;sex;Socioeconomic Status;therapy design;Tissues;Training and Education;Translations;Writing

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer

PI_NAMEs: METHENY, LELAND  (contact)

PROJECT_TERMS: Advocate;Amendment;anti-cancer research;authority;Biometry;Cancer Center Support Grant;Clinical;Clinical Cancer Center;clinical center;Clinical Data;Clinical Investigator;Clinical Protocols;Clinical Research;Clinical Research Protocols;clinical research site;Clinical Trials;Clinics and Hospitals;Committee Membership;Communication;Comprehensive Cancer Center;Constitution;Data;data management;Diagnostic;Disease;Doctor of Philosophy;Dose;Eligibility Determination;Ensure;Evaluation;Feedback;Foundations;Goals;Industry;Institution;Institutional Review Boards;Intervention;Intervention Studies;Malignant Neoplasms;member;Minority;Monitor;Observational Study;operation;Operations Research;Patients;Performance;Pharmacists;Play;Policies;Preventive;Procedures;Process;programs;Protocols documentation;Registered nurse;Research Priority;research study;Research Support;Resources;Review Committee;Role;Safety;sample collection;Scientific Evaluation;Scientist;Source;Strategic vision;Structure;System;Tissues;Toxic effect;United States National Institutes of Health;University Hospitals

PROJECT_TITLE: Procotol Review and Monitoring System


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics

PHR: Project narrative  Disruption of genomic regulation is accompanied by striking functional changes across cell types and species. However, how mobile genetic elements are regulated throughout life, across biological sexes, and how they influence physiology in response to external or internal cues, remains largely unknown. By leveraging big data and state-of-the-art experimental approaches on vertebrate models including mouse and the emerging African turquoise killifish, the proposed research program will advance our understanding of mobile genetic element control in healthy somatic cells, and shed light on how these elements can influence vertebrate health and disease. 1

PI_NAMEs: BENAYOUN, BERENICE ANATH (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TERMS: Adult;African;age related;Aging;Animal Model;Antibodies;Big Data;biological sex;Biology;cell type;Cells;cost effectiveness;Cues;Data;Development;Disease;DNA Transposable Elements;Elements;Family;Female;functional decline;functional genomics;Generations;Genetic;Genome;Genomics;Goals;Gonadal Hormones;Health;Homeostasis;Jumping Genes;Junk DNA;Killifishes;Laboratory mice;Life;life span;Link;Machine Learning;male;Malignant Neoplasms;Mobile Genetic Elements;model organism;Modeling;Mus;Nature;Nerve Degeneration;Organism;Parasites;parent project;Pattern;Physiology;prevent;programs;Regulation;Research;response;sex;Sex Chromosomes;sexual dimorphism;Somatic Cell;Time;Tissues;Validation

PROJECT_TITLE: Understanding the regulation and impact of transposable elements in Vertebrate health and disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: NEW YORK

ORG_DEPT: BIOLOGY

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE Nuclear pore complexes (NPCs) selectively transport cellular material into and out of the cell nucleus and are a nexus for the control of gene expression. Despite advances in our understanding of how NPCs are constructed, we still do not know how NPCs mediate and control key elements of nucleocytoplasmic transport and structurally adapt to perform specialized functions, such as accommodating high transport flux or passage of very large cargoes. Investigating these biological processes is necessary to understand how NPC defects can lead to many developmental, viral or oncogenic diseases, so opening up the possibility for drugs to therapeutically modulate NPCs.

PI_NAMEs: CAFFALETTE, CHRISTOPHER ALPERT (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Active Biological Transport;Address;Adopted;Affect;Affinity;Behavior;Binding Sites;Biological Assay;Biological Process;Capsid;Cell Nucleus;Cell Physiology;Cells;Communicable Diseases;Coupling;Cryoelectron Microscopy;Cytoplasm;Data;Defect;density;Dependence;Development;developmental disease;Disease;DNA;Drug Delivery Systems;Drug Targeting;Elements;Eukaryotic Cell;fitness;Fluorescence Microscopy;Gene Expression;gene therapy;Genome;Glycine;Goals;Hepatitis B Virus;HIV Infections;HIV-1;Human;In Situ;Infection;Interphase;Location;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Membrane;messenger ribonucleoprotein;Modeling;Molecular;multicatalytic endopeptidase complex;mutant;nanocarrier;nanoparticle;Nervous System Disorder;non-Native;Nuclear;Nuclear Energy;Nuclear Envelope;Nuclear Pore Complex;Nuclear Pore Complex Proteins;nucleocytoplasmic transport;Oncogenic;Pharmaceutical Preparations;Phenotype;Phenylalanine;preservation;Probability;Process;Proteins;Radial;Research;Research Personnel;Resolution;Ribosomes;RNA;Role;Running;Saccharomyces cerevisiae;Saccharomycetales;scaffold;Side;Site;small molecule;Structure;System;Tertiary Protein Structure;Therapeutic;transmission process;Transport Process;Viral;Visualization;Width;Yeasts

PROJECT_TITLE: Structure-function mapping of large cargo transport through the nuclear pore complex

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F04-S (20)]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Alcoholism, Alcohol Use and Health;Cannabinoid Research;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Rare Diseases;Substance Misuse

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE The Colorado Pulmonary Alcohol Collaborative (CoPARC) supports fundamental research to understand how alcohol misuse affects the lungs and extrapulmonary organs, thereby contributing to pneumonia and respiratory failure, along with other adverse health effects. CoPARC's infrastructure provides specimens and data from participants and patients with alcohol misuse, ranging from asymptomatic individuals to critically ill patients, with associated control groups. Investigators receiving materials from CoPARC will advance knowledge of strategies to minimize the impact of alcohol misuse on lung health, and improve outcomes in patients affected by pneumonia, respiratory failure, and the collateral damage that occurs in these conditions.

PI_NAMEs: BURNHAM, ELLEN L (contact)

PROGRAM_OFFICER_NAME: LIN, LI

PROJECT_TERMS: Acute;Acute Respiratory Distress Syndrome;Address;Administrative Supplement;Affect;airway epithelium;Alcohol consumption;alcohol misuse;alcohol research;Alcohols;Area;aspirate;Award;biobank;Biological;Biomedical Research;Blood;Blood specimen;Brain;Breathing;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Burn injury;California;career development;Cells;Chicago;Clinical;Clinical Data;Clinical Research;cohort;Collaborations;Collection;Colorado;Communities;community acquired pneumonia;Complement;Control Groups;Coronavirus;COVID-19;COVID-19 patient;COVID-19 pneumonia;Critical Illness;Data;Delirium;Development;Disease;dysbiosis;Enrollment;Epithelial Cells;Equipment and supply inventories;Erythrocytes;Exhalation;experience;Failure;Feces;Functional disorder;fundamental research;Funding;Goals;Grant;Habits;Health;Hospitalization;Human;Immune System Diseases;improved outcome;Individual;Infrastructure;Inhalation;Institution;Intestines;Investigation;Knowledge;Louisiana;Lung;Lung Diseases;lung health;Lung infections;marijuana user;Medical;Medical center;Medical Marijuana;Mental Health;Mission;Mononuclear;Muscle;Nasal Epithelium;National Institute on Alcohol Abuse and Alcoholism;Nebraska;Needs Assessment;neuromuscular;novel;Organ;Outcome;pandemic disease;Participant;participant enrollment;Pathogenesis;Patients;Phase;Physical condensation;physical conditioning;Physical Function;Plasma;Pneumonia;programs;Publications;Quality of life;R24;Recovery;Reporting;Research;Research Personnel;Residual state;Resolution;Resources;Respiration Disorders;respiratory;Respiratory Disease;Respiratory Failure;respiratory health;San Francisco;Science;Secure;Serum;Services;Site;Specimen;substance use;Survivors;Targeted Research;Trachea;Translational Research;translational scientist;Universities;Urine;Withdrawal

PROJECT_TITLE: CoPARC: Colorado Pulmonary-Alcohol Research Collaborative

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 DD (01)]


ADMINISTERING_IC: OH

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECT NARRATIVE (RELEVANCE) Identifying the mechanisms linking daily work conditions and corresponding strain reactions to unsafe commuting is a precursor to intervention development. The proposed project synthesizes a video-based naturalistic driving approach validated in the transportation safety community with a daily survey methodology widely used in occupational health research to explicate the process through which daily work conditions and work-related strain reactions influence worker safety while commuting.

PI_NAMEs: CALDERWOOD, CHARLES C (contact);HICKMAN, JEFFREY ;SMITH, RYAN CHRISTOPHER

PROJECT_TITLE: Mechanisms Linking Daily Work Conditions and Work-Related Strain Reactions to Unsafe Commuting

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: PALO ALTO

ORG_NAME: VETERANS ADMIN PALO ALTO HEALTH CARE SYS

PHR: The study will benefit Veterans by identifying a patient and family centered balanced set of quality measures of palliative and end of life cancer care to inform VA operations as well as further research. The study will prioritize indicators to extract, and that will become candidates for routine VA use, on the basis of direct patient and family input. In doing so, the study will set a standard for VA quality measurement in general; furthermore, it will create generalizable information on how Veterans and families can be more directly involved at the facility level as participants in quality measurement and improvement of palliative and end of life cancer care. ImPACS will characterize variation in quality measures prioritized by patients and family members to also show where VA can take action to improve care in response to Veteran and family priorities with a focus on disparities among rural and nonwhite Veterans.

PI_NAMEs: LORENZ, KARL  (contact);WALLING, ANNE M

PROJECT_TERMS: Advanced Malignant Neoplasm;Affect;American;Attention;Boston;cancer care;Cancer Center;cancer therapy;care systems;Caregivers;Caring;Characteristics;Clinical;Communication;Communities;Computer Assisted;Consultations;Consumption;cost;Data;Disease;Disparity;end of life;end of life care;ethnic disparity;Ethnic Origin;experience;Family;Family member;Fostering;Goals;health care disparity;health care service utilization;health care settings;Healthcare;Healthcare Systems;hospice environment;Hospitals;Improve Access;improved;innovation;Intervention;Interview;Learning;Life;Life Experience;Machine Learning;Malignant Neoplasms;Manuals;Measurement;Measures;Medical Records;Medicare;Mental Health;Methodology;Methods;Monitor;Natural Language Processing;operation;Opioid;Pain;Pain management;palliative;Palliative Care;Participant;Patients;Performance;Policies;Policy Maker;Process;Process Measure;Provider;Quality of life;Race;racial disparity;Recommendation;recruit;Research;response;Risk;Rural;rural disparities;rural residence;Sampling;side effect;Site;Surveys;Symptoms;System;systematic review;Text;Time;United States;United States Department of Veterans Affairs;urban disparity;Variant;Veterans;Voice;Work

PROJECT_TITLE: Improving Palliative Measurement Application with Computer-Assisted-Abstraction Study

STUDY_SECTION_NAME: HSR-6 Aging, Recovery, and Workforce[HSR6]


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Hoarding Disorder is a common and severe neuropsychiatric disorder that contributes to profound functional, social, and occupational disability, as well as increased risk for a number of adverse health outcomes and safety hazards. The research proposed in this fellowship application will comprehensively assess heterogeneity in the symptom profile of individuals with hoarding disorder and will provide greater insight into the etiology and developmental course of hoarding symptoms. This work will therefore propose a novel framework for detecting hoarding symptoms on a population level, knowledge that will improve both the identification and treatment of HD.

PI_NAMEs: NUTLEY, SARA  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: active lifestyle;Adult;Affect;Behavior;Brain Health Registry;career;Classification;Clinical;clinically significant;Clutterings;common symptom;Communities;comorbidity;Compulsive Hoarding;Data;Data Sources;Detection;Development;Developmental Course;Diagnosis;Diagnostic and Statistical Manual of Mental Disorders;Dimensions;disability;Disease;disorder risk;DSM-V;effective therapy;epidemiologic data;Etiology;Fellowship;follow-up;functional disability;Functional impairment;General Population;Geography;Goals;hazard;Health;health assessment;health related quality of life;Heterogeneity;Impairment;improved;Individual;Individual Differences;individualized medicine;innovation;insight;Internet;Intervention;Investigation;Knowledge;longitudinal course;Measures;Mental disorders;Modeling;Motivation;neuropsychiatric disorder;neuropsychiatry;novel;Occupational;older adult;Outcome;Participant;patient navigation;Patient Self-Report;Patients;Pattern;personalized medicine;Population;Prevention;Public Health;Questionnaires;Recording of previous events;Registries;Research;Research Personnel;Risk;Risk Factors;Safety;Severities;skills;social;Subgroup;symptomatology;Symptoms;Time;treatment program;Variant;Work

PROJECT_TITLE: The heterogeneity of hoarding behavior: characterizing disorder diversity to distinguish etiology and longitudinal symptom course

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-D(20)L]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: JACKSON

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: PROJECT NARRATIVE African Americans develop hypertension and its co-morbidities at an earlier age, have a greater frequency and severity of hypertension, have poorer control of blood pressure, and die disproportionately (2-fold) more from hypertension as compared to whites. Despite these known disparities, there has been little attention or advancement in the management of blood pressure in the African American population. Our laboratory’s advanced physiological model paired with novel analytic tools may mechanistically predict the types of patients that should respond to therapy, ultimately improving patient drug regimens and their success rate in this underserved and understudied population.

PI_NAMEs: CLEMMER, JOHN S (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Acceleration;African American;African American population;Age;Aldosterone;analytical tool;Angiotensin II;Animal Experiments;antagonist;Anti-Hypertensive Agents;Arterial Disorder;Arteriovenous fistula;Attention;Baroreflex;Blood Pressure;blood pressure control;Body System;Calcium Channel;Calibration;Cardiac Output;Clinical;Clinical Data;Clinical Treatment;clinically relevant;cohort;comorbidity;Complex;computer generated;Computer Models;Computer Simulation;Controlled Study;Data;data warehouse;Death Rate;Denervation;Development;Devices;Dimensions;Disease;Disparity;Diuretics;Endocrine;experimental study;Feedback;Frequencies;Generations;genetic epidemiology;Genomics;Glean;Glomerular Filtration Rate;Heart Rate;High Prevalence;Hormonal;Human;human model;Hypertension;hypertension control;hypertension treatment;hypertensive;improved;in silico;insight;Jackson Heart Study;Kidney;Laboratories;Literature;Machine Learning;machine learning algorithm;mathematical model;Mentors;Minority;model building;Modeling;Morbidity - disease rate;mortality;neural;novel;Obesity;patient population;patient response;Patients;Pattern;Peptidyl-Dipeptidase A;Peripheral Resistance;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;physiologic model;Physiological;Physiology;Population;Predictive Analytics;Prevalence;Probability;Process;Proxy;Publishing;Regimen;Research;Resistance;resistance mechanism;Resistant Hypertension;response;Severities;simulation;Socioeconomic Factors;Sodium Chloride;success;System;Techniques;Testing;therapeutic biomarker;therapy resistant;tool;Treatment Efficacy;treatment response;Variant;virtual;virtual model;virtual patient;Work

PROJECT_TITLE: Improving Hypertension Treatment in African Americans Using Computational Modeling and Predictive Analytics