NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Tobacco;Tobacco Smoke and Health

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Although the disparity of lung cancer survival in low-income people is well documented, the determinants of lung cancer care in this vulnerable population remain undetermined. In the population-based cohorts of lung cancer patients insured with Medicaid, we will assess the impacts of neighborhood contexts, Medicaid policies, and hospitals on cancer-directed treatment, tobacco cessation treatment, and cancer outcomes, as well as their contributions to racial disparities in lung cancer treatment and survival. The results will enhance our understanding of the mechanisms for socioeconomic and racial disparities in lung cancer care and survival, and will also help identify modifiable targets for future multilevel lung cancer disparity interventions.

PI_NAMEs: LIAN, MIN ;LIU, YING  (contact)

PROGRAM_OFFICER_NAME: DAVIDOFF, AMY

PROJECT_TERMS: Accounting;Address;Biological Models;cancer care;cancer diagnosis;cancer health disparity;Cancer Patient;cancer survival;cancer therapy;care outcomes;Caring;cohort;Collaborations;Colorectal Cancer;Continuity of Patient Care;Counseling;Data;data integration;data registry;Data Set;Data Sources;Databases;Diagnosis;Disease;Disparity;dual eligible;Early Diagnosis;Early treatment;Enrollment;Ensure;Environmental Risk Factor;Future;Geography;Guidelines;Health behavior and outcomes;health care availability;Health care facility;health equality;Health Policy;Health Services Accessibility;Healthcare;Healthcare Systems;High Prevalence;high risk;Hospitals;improved;Individual;Intervention;Investments;Link;Low income;Low Income Population;low socioeconomic status;lung cancer screening;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediastinal;Medicaid;medical vulnerability;medically underserved population;Medicare claim;Missouri;Modeling;Molecular;multilevel analysis;multimodality;neighborhood association;Neighborhoods;neoplasm registry;Nicotine Dependence;Non-Small-Cell Lung Carcinoma;Outcome;Patients;Pattern;Pharmacotherapy;Play;Policies;population based;population health;Population Study;Primary Care;prior authorization;Privatization;programs;Provider;public policy on tobacco;racial difference;racial disparity;Recommendation;Risk;Role;Rural;rural patients;Safety;Screening for cancer;SEER Program;Smoke;smoke-free policy;Smoker;Smoking;socioeconomic disparity;Specialist;Staging;standard care;Surveys;survival disparity;targeted treatment;Taxes;Testing;Tobacco;tobacco cessation intervention;Translating;Transportation;transportation access;treatment program;Underserved Population;Vulnerable Populations;Work

PROJECT_TITLE: Impacts of Neighborhood Contexts and Medicaid Policy on Lung Cancer Survival in Low-SES Patients

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Prevention;Rare Diseases;Skin Cancer

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: In sub-Saharan Africa, the cancer known as Kaposi’s sarcoma (KS) remains a significant problem among HIV-infected patients. Diagnosis often does not occur until patients develop advanced disease and survival is poor. We will apply a technique known as Rapid Case Ascertainment (RCA) to inform efforts aimed at controlling KS; improve our understanding of why KS still occurs despite antiretroviral therapy; and evaluate novel strategies for KS diagnosis and linkage of patients newly diagnosed with KS to cancer care.

PI_NAMEs: BYAKWAGA, HELEN  (contact)

PROJECT_TERMS: Address;Adult;advanced disease;Africa;Africa South of the Sahara;African;AIDS related cancer;Algorithms;antiretroviral therapy;Biological;Biological Markers;cancer care;career development;Caring;CD4 Positive T Lymphocytes;Cell Count;Cervical dysplasia;Cessation of life;chemotherapy;Clinic;clinically relevant;Collection;Control Groups;Coupled;Data;deep learning algorithm;Development;Diagnosis;Digital Photography;Disease;Early Diagnosis;Epidemiology;epidemiology study;Evaluation;experience;follow-up;Funding;Geographic Locations;Goals;Guidelines;HIV;HIV Infections;Human Herpesvirus 8;Image;immune activation;improved;Incidence;Institution;Intervention;Kaposi Sarcoma;Kenya;Leadership;Link;Localized Malignant Neoplasm;Malignant - descriptor;Malignant Neoplasms;Measurement;Mediating;Mentorship;Monitor;National Comprehensive Cancer Network;Newly Diagnosed;novel;novel strategies;oncology service;Outcome;Participant;Pathogenesis;Patient imaging;patient navigation;Patients;Persons;Photography;Plasma;Prevention;Process;rapid diagnosis;Reporting;Research;Research Personnel;Research Project Grants;Resources;RNA;Role;Scientist;Services;skin biopsy;skin lesion;systemic inflammatory response;Tanzania;Techniques;Testing;Time;tool;Uganda;United States;virus related cancer

PROJECT_TITLE: Project 2: Rapid Case Ascertainment as a Tool for Epidemiologic Investigation and Efficient Linkage to Care in HIV-infected Patients Diagnosed with Kaposi Sarcoma in East Africa


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SALT LAKE CITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Sepsis is a common syndrome of dysregulated immune responses to infection that occurs in all ages and populations. Without a clear understanding of the complex biology that causes these responses we cannot provide effect treatments to minimize the risk of death or long-term complications. This proposal has the potential to uncover biology to lead to therapeutic improvements for the treatment of sepsis.

PI_NAMEs: MIDDLETON, ELIZABETH ANNE (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: Acute;adverse outcome;Affinity;Age;Agonist;Animal Model;Antibiotics;Automobile Driving;Award;biological research;Biology;Blood Platelets;cecal ligation puncture;Cells;Clinical;clinical application;Clinical Trials;Complex;Critical Care;Data;design;Event;Failure;Fc Immunoglobulins;Fc Receptor;Functional disorder;Future;Gene Expression;Genetic Transcription;Goals;Grant;hemodynamics;Hemostatic Agents;Hemostatic function;Hospitals;Human;Hyperactivity;IACUC;IgG Receptors;Immune;Immune response;Immunologic Receptors;improved;Infection;Inflammation;Inflammatory;innovation;Institutional Review Boards;Integrins;Knowledge;Laboratories;Lead;Lung;Megakaryocytes;Mentors;Messenger RNA;Molecular Profiling;Morbidity - disease rate;mortality;mortality risk;mouse model;mRNA Expression;Mus;new therapeutic target;Outcome;Parents;pathogen;Patient Care;patient response;pharmacologic;Physicians;Platelet Count measurement;platelet function;Population;Positioning Attribute;programs;protein expression;Proteins;Protocols documentation;Publishing;Quality of life;receptor expression;Regulation;Research;Research Personnel;response;Resuscitation;ribosome profiling;Risk;risk minimization;Role;Scientist;Sepsis;sepsis induced ARDS;septic;septic patients;Signal Transduction;skills;Stimulus;Supportive care;Syndrome;System;Techniques;Testing;Therapeutic;Thrombosis;Time;Transcript;Transcriptional Regulation;transcriptome;Transgenic Mice;Transgenic Organisms;Translational Regulation;Translational Research;translational research program;Translations;treatment effect;Tyrosine;Universities;Up-Regulation;Utah;Work

PROJECT_TITLE: The regulation and function of platelet FcARIIA in sepsis


ADMINISTERING_IC: DK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative Acute kidney injury (AKI) afflicts 1.2 million hospitalized patients annually in the US, and 20-50% of survivors of AKI progress to chronic kidney disease (CKD) as a result of failed renal repair. There are no available therapies to enhance renal repair/regeneration, underscoring an immense unmet clinical need. In this application, we seek to determine molecular mechanisms that underlie how oxidative stress impedes renal repair/regeneration and establish a proof of principle that activating anti-oxidative stress pathways can enhance renal repair and prevent the AKI-to-CKD transition.

PI_NAMEs: SOUMA, TOMOKAZU  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Affect;Automobile Driving;Candidate Disease Gene;Cardiovascular system;Cell Death;Cell Survival;Cells;cellular targeting;Chronic;Chronic Kidney Failure;Clinical;clinically relevant;Coenzyme A Ligases;comparative;Data;defined contribution;Development;Disease Progression;Double Minutes;effective therapy;End stage renal failure;Enzymes;Epithelial Cells;epithelial injury;epithelial repair;epithelial stem cell;Etiology;Event;exhaustion;Foundations;Functional disorder;Gene Modified;Genes;Genetic;glutathione peroxidase;healing;Health;high risk;Hospitalization;Human;Impairment;improved;In Situ Hybridization;in vivo;Inflammatory;Injury;Injury to Kidney;Internal Ribosome Entry Site;Investigation;Ischemia;Kidney;Knowledge;Lipid Peroxidation;LoxP-flanked allele;Maps;Mediating;Medical;Modeling;Molecular;mortality;mouse genetics;mouse model;Multiple Trauma;Mus;Natural regeneration;novel;novel therapeutic intervention;novel therapeutics;Outcome;Oxidative Stress;Oxidative Stress Induction;Oxidative Stress Pathway;Pathogenicity;Pathway interactions;Patients;Population;prevent;Process;progenitor;regeneration function;regenerative;renal damage;renal epithelium;renal ischemia;Renal tubule structure;repaired;Reperfusion Injury;Research;Resolution;Role;sex;Signal Pathway;single-cell RNA sequencing;stem cell function;stem cell population;Survivors;Testing;Therapeutic;tool;transcriptome;transcriptomics;Tubular formation

PROJECT_TITLE: Targeting Renal Tubular Epithelial Progenitors in AKI to CKD transition

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PI_NAMEs: STRICK, PETER  (contact)

PROJECT_TERMS: Affective;Architecture;Biohazardous Substance;Central Nervous System;Cognitive;Collaborations;Communities;Core Facility;experimental study;Foundations;Funding;Goals;Herpesviridae;Individual;insight;interest;International;investigator training;Methods;Motor;Nervous System;neural circuit;Neuroanatomy;neuronal transport;Neurons;Neurosciences;neurotropic virus;nonhuman primate;novel;Pilot Projects;Privatization;Rabies virus;Reagent;Recording of previous events;repository;Research;Resources;Sensory;Source;Synapses;Techniques;Technology;Time;Tracer;Training;United States National Institutes of Health;Universities;Viral;Virus

PROJECT_TITLE: Resource

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-D]


PROJECT_TERMS: Affective;Applied Research;Architecture;Biohazardous Substance;Central Nervous System;Cognitive;Collaborations;Communities;experimental study;Foundations;Funding;Goals;Herpesviridae;Individual;insight;interest;International;Methods;Motor;neural circuit;Neuroanatomy;neuronal transport;Neurons;Neurosciences;neurotropic virus;novel;novel strategies;Privatization;Rabies virus;Reagent;Recording of previous events;Research;Resources;Sensory;Synapses;Targeted Research;Techniques;Technology;Testing;Time;Tracer;Training;United States National Institutes of Health;Universities;Virus

PROJECT_TITLE: Applied Research


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BLOOMINGTON

ORG_DEPT: CHEMISTRY

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative The proposed research aims to uncover information that is essential to develop a new schistosomiasis control strategy. The work also aims to determine which molecules are fundamentally required for the evolution of animal cellular adhesion and chemotaxis—important phenotypes for a range of diseases from immune disorders to cancer metastasis. Because this project is uniquely applicable both to a neglected tropical disease and to some of the most common diseases in the U.S., it is relevant to human health and the NIH’s mission to reduce illness.

PI_NAMEs: GERDT, JOSEPH P. (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adhesions;Animals;Behavior;Biocontrols;Biomphalaria;Cadherins;cancer cell;Cell Adhesion;Cell Adhesion Process;Cell-Cell Adhesion;Cells;Cellularity;Chemicals;Chemotactic Factors;Chemotaxis;Complex;Cues;Disease;Disseminated Malignant Neoplasm;Environment;Evolution;Exhibits;Genes;Health;Human;human pathogen;Immune;Immune System Diseases;in vivo evaluation;Infection;insight;Integration Host Factors;Integrins;intercellular communication;migration;Mission;Modeling;Molecular;neglected tropical diseases;Neoplasm Metastasis;Neural Crest Cell;Organism;Phenotype;Phylogenetic Analysis;programs;receptor;Reporting;Research;response;Schistosoma;Schistosomiasis;Serum;Signal Transduction;Snails;trait;United States National Institutes of Health;vector transmission;Work

PROJECT_TITLE: Elucidation of the first interspecies chemical signaling mechanisms in Capsaspora owczarzaki--the predator of a human pathogen and a model for the evolution of animal multicellularity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Nanotechnology;Neurosciences;Racial and Ethnic Minority Health Research;Stroke

ORG_CITY: ATLANTA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Here we investigate a blood test to identify stroke patients who are eligible for tPA therapy. We use whole blood whole transcriptomic to analyze blood RNA patterns to identify signatures of stroke, and then test the impact of sex and race on this test accuracy. Finally we investigate a novel rapid sequencing approach which has the potential to enable timely point of care transcriptome analysis for stroke diagnosis.

PI_NAMEs: MELLER, ROBERT  (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: Accreditation;acute stroke;Adjuvant;Admission activity;Affect;African American;African American population;African Women;Alteplase;base;Biological;Biological Assay;Biological Markers;Blood;Blood specimen;Blood Tests;Brain hemorrhage;Brain Ischemia;Cardiovascular Diseases;Caucasians;Cause of Death;Cerebral hemisphere hemorrhage;Clinical;Collaborations;cryptogenic stroke;Data;Data Analyses;data modeling;Data Set;Diagnosis;Diagnostic;diagnostic panel;diagnostic signature;Diagnostic tests;disability;Disease;effective therapy;Eligibility Determination;Emergency Department Physician;Exclusion;experimental study;gene environment interaction;Genetic Transcription;Genomics;Goals;Hemorrhage;high risk;Hospitals;Hour;imaging facilities;improved;improved outcome;Ischemia;Ischemic Stroke;Joints;Libraries;male;Measurement;Measures;Methods;Minority Groups;Morbidity - disease rate;Morehouse School of Medicine;mortality;nanopore;Needles;next generation;next generation sequencing;novel;outcome prediction;Patient Recruitments;Patients;Pattern;peripheral blood;Pharmaceutical Preparations;Phenotype;point of care;point-of-care diagnostics;Population;predictive modeling;Preparation;programs;Race;radiologist;rapid test;Reading;Recovery;Research;Research Personnel;response;Risk;RNA;secondary analysis;Severities;sex;side effect;Site;Speed;Stratification;Stroke;stroke incidence;stroke patient;Symptoms;Techniques;Technology;Testing;Therapeutic;Thrombolytic Therapy;Time;transcriptome;transcriptome sequencing;transcriptomic profiling;transcriptomics;treatment response;Universities;Venous;Whole Blood;Woman;women patients;X-Ray Computed Tomography

PROJECT_TITLE: Blood transcriptomics as CT adjuvant to exclude hemorrhage in acute stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Innate threat behavior offers a new avenue for the study of trauma-related psychiatric disorders, and involves locus coeruleus norepinephrine neurons. The goal of this project is to identify threat computations specific to norepinephrine cell-types across molecular, cellular, and circuit scales using newly developed norepinephrine biosensors, head-mounted microendoscope calcium imaging, and transcriptomics. This work will demonstrate the relationship between norepinephrine cell-types and network activity in defensive behaviors, thus laying a foundation for future studies to improve threat-related symptoms in psychiatric disorders.

PI_NAMEs: KAYE, ALFRED P (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Anatomy;Arousal;Autopsy;Behavior;Behavioral;Behavioral Paradigm;Biosensor;Brain;brain control;Calcium;career;cell type;Cells;Complement;Complex;Computer Analysis;computer framework;Computer Models;Cues;Data;differential expression;Disease;Dissection;Electrophysiology (science);Emotional;experience;experimental study;Exploratory Behavior;Exposure to;Foundations;Fright;Funding;Future;Gene Expression Profile;Genes;Goals;Head;Heterogeneity;Human;Image;improved;in vivo;Individual;innovation;K-Series Research Career Programs;Knowledge;Learning;Literature;locus ceruleus structure;Mental disorders;Mentors;Mentorship;Methods;microendoscope;Microscope;Modeling;Molecular;Mus;Nature;neural circuit;Neurobiology;neurochemistry;Neuromodulator;Neurons;Neurotransmitters;noradrenergic;Norepinephrine;norepinephrine system;novel;optical imaging;Optics;optogenetics;Pattern;Physicians;Physiology;Population;Post-Traumatic Stress Disorders;Predatory Behavior;Prefrontal Cortex;programs;Psychiatrist;Psychological reinforcement;Reporting;Research;response;Role;Scientist;Shelter facility;single cell sequencing;single nucleus RNA-sequencing;single-cell RNA sequencing;Source;Stimulus;Stress;Structure;Symptoms;System;Techniques;Training;transcriptome sequencing;transcriptomics;Trauma;Visit;Visual;Work

PROJECT_TITLE: Determining the role of noradrenergic heterogeneity in innate threat response

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Skin Cancer

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Our studies focus on UCHL5, a deubiquitinase enzyme and a member of Ino80 chromatin remodeling complex. We propose to study in depth mechanism of role of UCHL5 and subsequent epigenomic reprogramming in promoting melanoma metastasis as well as test the effect of its inhibitor on growth of metastatic melanoma. Our work is expected to provide critical biological insights into the role of epigenome in metastasis that could have broad implications for melanoma and other malignancies.

PI_NAMEs: RAI, KUNAL  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Actins;Animal Model;ATAC-seq;Automobile Driving;Biological;Biological Assay;Cell Line;cell motility;Cells;Cessation of life;Chemicals;ChIP-seq;Chromatin;Chromatin Loop;chromatin modification;Chromatin Remodeling Factor;cofilin;Complex;Cytoskeleton;Data;depolymerization;Disease;DNA Methylation;driving force;Elements;Enhancers;Environment;Enzymes;Epigenetic Process;epigenome;epigenomics;epithelial to mesenchymal transition;Event;Experimental Genetics;experimental study;F-Actin;FDA approved;Felis catus;Filopodia;follow-up;G Actin;gain of function;Gene Expression;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;Growth;Higher Order Chromatin Structure;Human;Hydrolase;Image;In Vitro;in vivo;inhibitor;insight;Invaded;knock-down;Knockout Mice;LIMK1 gene;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;member;Metastatic Melanoma;Modeling;Neoplasm Metastasis;novel;Nucleosomes;Oncogenes;overexpression;Pathway interactions;Patients;Pharmacologic Substance;Phenotype;Phosphoproteins;Polycomb;Positioning Attribute;pre-clinical;Pre-Clinical Model;Process;promoter;Proteins;Regulation;Research Personnel;Role;Signal Transduction;standard of care;stemness;Structure;Technology;Testing;Therapeutic;therapeutic target;transcriptome;Transgenic Animals;Ubiquitin;ubiquitin C-terminal hydrolase;ubiquitin isopeptidase;Validation;Work;World Health;Xenograft Model;YY1 Transcription Factor

PROJECT_TITLE: UCHL5 as a regulator and therapeutic target in metastatic melanoma

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Microbiome;Neurodegenerative;Neurosciences

ORG_NAME: EMORY UNIVERSITY

PHR: Project Narrative: Alzheimer’s disease—an incredibly debilitating dementia currently affecting more than 6 million people in the United States—is associated with changes in the gut microbiome that may contribute to disease progression by shaping neuroinflammatory responses to pathology. While microbiome-disease associations are described, the contribution of specific Alzheimer’s disease-linked bacteria is unknown. The present study aims to pinpoint the specific effects of individual Alzheimer’s disease-associated microbes on neuroimmune and disease outcomes and evaluate the cellular pathways and bacterial molecules involved in transmitting these signals from gut-to- brain, thus allowing for the identification of novel treatment targets.

PI_NAMEs: BLACKMER-RAYNOLDS, LISA  (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: abeta accumulation;Acceleration;Affect;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid;Amyloid beta-Protein;Bacteria;Bacteroidaceae;Bacteroides thetaiotaomicron;Behavioral;Brain;Brain Pathology;career;Caregivers;Cell Communication;cell type;Cells;Clinical Trials;Cognition;Cognitive;Communication;cytokine;Data;Data Set;Dementia;Development;Disease;Disease Outcome;Disease Progression;disorder risk;dysbiosis;Enterobacteriaceae;Escherichia coli;Etiology;Failure;Functional disorder;functional outcomes;Gene Expression Profile;Genetic Transcription;Germ-Free;Gnotobiotic;gut bacteria;gut dysbiosis;gut microbes;gut microbiome;Health;Immune;Immune signaling;immunoregulation;Impaired cognition;improved;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;innovation;insight;interdisciplinary approach;Lactobacillus;Link;Macrophage;Mediating;Microbe;microbial;microbial colonization;microbiome;microbiome composition;Microglia;Modeling;Molecular Biology;monocyte;mouse model;Mus;mutant;National Research Service Awards;Nervous System Physiology;Neuroimmune;neuroinflammation;Neurons;neuropathology;Neurosciences;neurotoxicity;neurotransmission;novel;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Persons;Phagocytes;pharmacologic;Public Health;Research;response;Risk Factors;Role;Shapes;Signal Transduction;single nucleus RNA-sequencing;stem;Symptoms;System;tau Proteins;Techniques;Testing;therapeutically effective;Time;Tissues;Training;transcriptomics;transmission process;United States;Wild Type Mouse

PROJECT_TITLE: Microbiome-microglia interactions in Alzheimer’s disease pathophysiology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F01A-V(20)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Breast Cancer;Cancer;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

PHR: The goal of this study is to design and develop a fully characterized novel tissue engineered disease model of aged tissue environment integrated with a mouse model as a system to study the role of aging in disease initiation and progression. With a fully integrative approach implementing human tissue analysis, state-of-art tissue engineering approaches and by incorporating the engineered tissues in a hybrid mouse model for physiological relevance, we propose a highly interdisciplinary project to reconstruct and validate aged human tissue at the molecular, cellular and physiological levels. The tissue engineered 3D models as well as the hybrid mouse models developed here will be of great importance in isolating the effects of aged human (i) ECM, (ii) stromal cells, and (iii) disease cells on disease progression.

PI_NAMEs: ZORLUTUNA, PINAR  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Adipocytes;Age;age effect;age related;age related changes;aged;Aging;aging related;aging related disease;Animal Model;anti-cancer research;Antineoplastic Agents;Basement membrane;Basic Cancer Research;Benchmarking;Biochemical;Biological Models;biophysical properties;Breast;Breast Cancer Prevention;Breast Carcinoma;cancer type;Cancerous;Cardiovascular Diseases;cell age;cell behavior;Cells;Characteristics;Clinical;clinical translation;Collagen;Control Groups;Data;Data Set;design;Development;Disease;disease model;Disease Progression;Distant Metastasis;drug discovery;drug efficacy;drug testing;Engineering;Environment;Epithelial Cells;experimental study;extracellular;Extracellular Matrix;Fiber;Fibroblasts;Gene Expression;glycosylation;Goals;Human;human old age (65+);human tissue;Hybrids;Immunodeficient Mouse;Implant;In Vitro;in vivo;in vivo Model;Incidence;Individual;Invaded;Literature;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Metastatic Neoplasm to the Lung;Modeling;Molecular;mouse model;Mus;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Neurodegenerative Disorders;next generation;novel;Onset of illness;Organoids;Patients;Pharmaceutical Preparations;Phenotype;physiologic model;Physiological;Play;Porosity;pre-clinical;Pre-Clinical Model;pre-clinical research;Primary Cell Cultures;Property;protein expression;Proteomics;Research;response;Risk Factors;Role;Sampling;Science;Stromal Cells;Stromal Invasion;Structure;success;System;Testing;The Cancer Genome Atlas;three-dimensional modeling;Time;Tissue Banks;Tissue Engineering;Tissues;transcriptomics;translational cancer research;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor-Derived;Work;Xenograft procedure;yeast two hybrid system

PROJECT_TITLE: Engineered hybrid aging model for disease progression


ORG_CITY: ANN ARBOR

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Familial partial lipodystrophy 2 (FPLD2) is a rare disease that causes adipose tissue loss, dysfunction, and redistribution; FPLD2 is caused by mutations in LMNA, which encodes proteins important for nuclear function and gene expression. Mechanistic studies are required to understand how and why loss of LMNA function leads to FPLD2, and to reveal therapeutic targets for lipodystrophy patients. This project uses inducible adipocyte-specific Lmna knockout and other mouse models to identify mechanisms of adipocyte loss, which I hypothesize occurs because reduced lipogenic gene expression leads to an inability of adipocytes to maintain their lipid stores.

PI_NAMEs: MAUNG, JESSICA NANDA (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;adipocyte biology;Adipocytes;adiponectin;Adipose tissue;Adult;Age;Alleles;Architecture;autosome;Blood Glucose;Cell Death;Cells;Characteristics;Chromatin;comparison control;Data;Deposition;Development;Diabetes Mellitus;DNA Binding;Down-Regulation;experimental study;Familial partial lipodystrophy;Fatty Liver;Fluorescent in Situ Hybridization;Foundations;Functional disorder;functional loss;Future;Gene Expression;gene synthesis;Genes;Global Change;Health;Hepatic;Homeostasis;Human;Hyperlipidemia;Immune;in vivo;Inflammatory;Injections;insight;Insulin;Knock-out;Knockout Mice;Knowledge;Lamin Type A;Lead;Leptin;lipid biosynthesis;lipid metabolism;Lipids;Lipodystrophy;Lipolysis;Location;LoxP-flanked allele;Maintenance;Metabolic dysfunction;Mitochondria;Modeling;Molecular;Morphology;mouse model;Mus;Mutation;new therapeutic target;Nuclear;Nuclear Lamina;Pathogenicity;Pathway interactions;Patients;Phenotype;Positioning Attribute;postnatal;prevent;Proteins;Proteomics;Puberty;Publishing;Rare Diseases;Reporter;Role;Secondary to;Shapes;Structure;subcutaneous;Tamoxifen;Testing;therapeutic target;Tracer;transcription factor;transcriptome sequencing;Triglycerides;Up-Regulation;Variant;vector;Visceral

PROJECT_TITLE: Mechanisms of adipocyte loss in mouse models of familial partial lipodystrophy 2


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Neurosciences;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative: We propose a new study to determine the role of cyclohexanone, an organic solvent contaminant of medical plastics, in mediating adverse cardiovascular outcomes in neonatal cardiac surgery. We will determine cyclohexanone and its breakdown products effect on test MP and validation U Michigan and CATCH studies morbidity, mortality, and neurodevelopmental outcomes, determine mechanism of toxicity by examining in vitro neural cell and brain slice culture, effects on the blood brain barrier and in vivo on learning and memory and whether exposure can be reduced by CPB circuit manipulation. Reduction of organic solvent exposure from medical plastics offers an opportunity for an immediate and actionable means to improve neonatal cardiac surgical outcomes.

PI_NAMEs: EVERETT, ALLEN D (contact);GRAHAM, DAVID R. M.

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: 5 year old;Adrenal Cortex Hormones;Adverse effects;age related;Animal Model;Animals;Attention;Attention deficit hyperactivity disorder;Biological Assay;Blood - brain barrier anatomy;Blood Banks;Brain;Brain Injuries;cardiac intensive care unit;Cardiac Surgery procedures;Cardiopulmonary Bypass;cardiovascular effects;Cardiovascular system;Cell Death;cell type;Cessation of life;Chemicals;Child;Childhood;Clinical;Clinical assessments;cohort;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Congenital Heart Surgery;Cyclohexanones;Data;Development;disability;Environment;Excision;executive function;Exposure to;fabrication;Goals;Healthcare;Human;Hyperactivity;improved;improved outcome;In Vitro;in vivo;in vivo Model;Industrialization;Infant;Infusion procedures;innovation;Intravenous infusion procedures;IV Fluid;Learning;Length of Stay;Magnetic Resonance Imaging;Maps;Measures;Mediating;Medical;Medical Device;Memory;Metabolism;Methods;Methylprednisolone;Michigan;Molecular;molecular sieving;Morbidity - disease rate;mortality;Motor;motor deficit;Multicenter Trials;National Heart, Lung, and Blood Institute;Neonatal;neonatal brain;neonate;neural;neurodevelopment;neurodevelopmental effect;Neurons;novel;Operative Surgical Procedures;Organic solvent product;Outcome;Patients;Perioperative;perioperative morbidity;pharmacologic;Phenotype;Placebos;Plastics;Postoperative Period;Prevention strategy;Randomized;Rattus;Rodent Model;Role;Sampling;Serum;Slice;Solvents;Source;Structure;success;surgery outcome;Survivors;Techniques;Testing;Thrombosis;Toxic effect;Toxicology;Tube;Universities;Validation;Ventilator;white matter injury;Zeolites

PROJECT_TITLE: Role of Cyclohexanone Toxicity in Mediating Congenital Cardiac Surgery Outcomes

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative - Overall The Myeloproliferative Neoplasm Research Consortium (MPN-RC) is an inter-active group of laboratory and clinical scientists from 13 institutions who work in a coordinated fashion to develop and evaluate therapeutic strategies that will improve the survival of patients with myelofibrosis (MF). We hypothesize that combinations of drugs which act by directly targeting malignant hematopoietic stem cells and/or by correcting their tumor promoting micro-environments can be used to deplete the numbers of cancer stem cells. The overall goal of the MPN-RC is to employ the complementary skills and efforts of its scientifically diverse membership to generate the scientific foundation for novel therapeutic strategies which will be evaluated in rigorous, well- constructed independent investigator-initiated clinical trials to prolong the survival of MF patients.

PI_NAMEs: HOFFMAN, RONALD  (contact)

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: Acute Myelocytic Leukemia;Address;Affect;Allogenic;Attenuated;Biological;Biological Markers;Blast Phase;cancer stem cell;Cell Compartmentation;Clinical;clinical practice;Clinical Research;Clinical Trials;Clonal Hematopoietic Stem Cell;Credentialing;curative treatments;cytopenia;Data;Disease;Doctor of Medicine;Drug Combinations;Event;Evolution;fitness;Foundations;Generations;Goals;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hemorrhagic Thrombocythemia;improved;improved outcome;Individual;Inflammatory;inhibitor;inhibitor therapy;insight;Institution;Interruption;JAK2 gene;Laboratories;Laboratory Study;Maintenance;Malignant - descriptor;Measures;Modality;Myelofibrosis;Myeloproliferative disease;Neoplasms;novel;novel therapeutic intervention;Outcome;Pathway interactions;Patients;Phase I/II Clinical Trial;Phase III Clinical Trials;Polycythemia Vera;pre-clinical;preclinical study;Primary Myelofibrosis;Quality of life;rational design;reduce symptoms;Research;Research Personnel;response;Role;Science;Scientist;Signal Pathway;Signal Transduction;skills;small molecule;Solid Neoplasm;stem cell exhaustion;Stem cell transplant;stem cells;support network;synergism;targeted treatment;Therapeutic;Therapeutic Studies;therapy design;Translational Research;tumor microenvironment;Tumor Promotion;United States;Work


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Hematology;Human Genome;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: NARRATIVE There is a need for new treatments for myelofibrosis (MF) patients based on laboratory insight into disease pathogenesis. We will use studies of preclinical models of MF and primary patient samples to understand how different mutations and biological pathways contribute to MF development and to test novel treatment approaches. Most importantly, the studies in this project are aimed to validate novel therapies that can then be rapidly tested in clinical trials in this research consortium.

PI_NAMEs: LEVINE, ROSS L (contact)

PROJECT_TERMS: Acute leukemia;adverse outcome;antagonist;Attenuated;Biological;Blast Phase;Bone Marrow;Cells;chemokine;chemokine receptor;Clinic;Clinical;clinical development;Clinical Trials;Coculture Techniques;Collaborations;Coupled;Credentialing;CRISPR library;CXCR;cytokine;cytopenia;Data;Dependence;Development;Disabling;Disease;DNA;Epigenetic Process;epigenomics;experience;functional genomics;Genes;Genomics;Genotype;Hematopoietic;Hemorrhagic Thrombocythemia;Human;IL8 gene;IL8RB gene;in vivo;Inflammation Mediators;Inflammatory;inhibitor;insight;JAK2 gene;Janus kinase;kinase inhibitor;Laboratories;Leukemic Cell;Ligands;Malignant - descriptor;MDM2 gene;Megakaryocytes;Methylation;Modeling;Molecular;mouse model;mutant;Mutation;Myelofibrosis;Myeloproliferative disease;new therapeutic target;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathologic;Pathway interactions;Patients;Phosphotransferases;Polycythemia Vera;pre-clinical assessment;Pre-Clinical Model;preclinical study;Preleukemia;Primary Myelofibrosis;Production;progenitor;Prognosis;Proteins;Refractory;Research;response;RNA;Role;Sampling;Signal Transduction;Splenomegaly;standard of care;STAT3 gene;stem cell survival;stem cells;Symptoms;synergism;System;targeted agent;Testing;Therapeutic;Therapeutic Studies;Tissue Banks;TP53 gene;Treatment Efficacy;treatment response;Work

PROJECT_TITLE: Project 1: Molecular Pathogenesis and Therapy of Myelofibrosis


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Zebrafish models are invaluable tools to our understanding of human health and disease and have taught us much of what we know about biology. Immense efforts have gone into the generation of transgenic, reporter, and mutant lines; however, maintaining live fish indefinitely has become a huge cost burden that also puts animals at risk. This project aims to develop a flexible zebrafish cryopreservation protocol that is compatible with multiple developmental stages, including embryos and larvae, and to train external labs with an easy to implement protocol through extensive dissemination efforts.

PI_NAMEs: TESSIER, SHANNON NOELLA (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Adopted;Adult;Animals;animation;Biological Models;Biological Products;Biology;Biomedical Research;Breeding;cell injury;Communicable Diseases;Communities;Complex;cost;cryogenics;Cryopreservation;Crystallization;design;Development;Disease;Dry Ice;Educational process of instructing;egg;Embryo;embryo cryopreservation;Engineering;Ensure;Environmental Risk Factor;Event;experimental study;extracellular;Failure;Fishes;flexibility;Freezing;Generations;Genes;Genetic;Genome;Glass;Health;high throughput screening;Human;Human Resources;Ice;Image;imaging study;improved;improved outcome;inhibitor;Injectable;Interruption;Laboratories;Larva;Length;Liquid substance;Long-Term Effects;Maintenance;Mediating;Methods;model organism;Modeling;Modification;Molecular;mutant;Names;Nature;Nitrogen;novel therapeutics;Organism;Outcome;Oxygen;preservation;prevent;Procedures;Protocols documentation;Rana;Recovery;Reporter;reproductive;Research;Research Personnel;Resources;Risk;Running;Sampling;Specimen;Sperm Banks;sperm cryopreservation;Standard Preparations;stress tolerance;success;Survival Rate;System;Temperature;Testing;Time;tool;Training;Transgenic Organisms;Trehalose;user-friendly;Validation;Vial device;Visit;Water;Wood material;Work;Zebrafish

PROJECT_TITLE: Cryopreservation of zebrafish larvae and embryos for biomedical research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(55)R]


NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Stroke

ORG_CITY: CINCINNATI

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: RELEVANCE: The change in stroke occurrence and recurrence over time is the ultimate test of how well science has translated new discoveries into benefits for the population. Our study has examined racial disparities in stroke over the last 25 years, showing that blacks have higher risk for stroke than whites. In our population, the occurrence of stroke is decreasing in whites but NOT African-Amerians, and we will continue to describe trends in stroke occurrence, recurrence, cause, treatment, and outcome in a biracial metropolitan population.

PI_NAMEs: KISSELA, BRETT M (contact);KLEINDORFER, DAWN O

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Acute;Address;administrative database;African American population;Age;Age of Onset;Anticoagulants;Attenuated;Benchmarking;biracial;Black Populations;Black race;Blood Platelets;Brain hemorrhage;Case Fatality Rates;Case Series;Censuses;Clinical;Clinical Data;clinical practice;Clinical Trials;Cognitive;cohort;Collaborations;Communities;Community Hospitals;County;Data;disability;Disparity;Eligibility Determination;Epidemiology;EuroQOL;Evaluation;Event;Exclusion Criteria;functional outcomes;Funding;Future;health disparity;Health Services Accessibility;high risk;Hospitals;improved;Incidence;Intervention Studies;Ischemic Stroke;Kentucky;Knowledge;men;Methods;metropolitan;Monitor;mortality;novel;Outcome;Outpatients;Participant;Patients;Physicians;Population;population based;Population Study;population survey;post stroke;post stroke depression;Prevalence;Prevention;Prevention trial;prospective;Public Health;Quality of life;racial difference;racial disparity;radiological imaging;rate of change;Recovery;Recurrence;Research;Research Personnel;Resources;Risk Factors;Science;Secondary Prevention;Sex Differences;sex disparity;Site;Source;Stroke;stroke clinical trials;stroke event;stroke incidence;stroke intervention;stroke outcome;stroke patient;Stroke prevention;stroke recovery;stroke risk;stroke therapy;Surveys;Testing;Time;Time trend;Transient Ischemic Attack;Translating;trend;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Comparison of Hemorrhagic & Ischemic Stroke Among Blacks and Whites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-W(02)]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: PROJECT NARRATIVE Myelofibrosis (MF) is a disease characterized by the accumulation of abnormal megakaryocytes that contribute to progressive bone marrow fibrosis and impaired hematopoiesis. The goal of this project is to understand the events that contribute to disease progression by focusing on megakaryocytes and the factors that they secrete and respond to, such as TGF- and IL-13. We aim to deliver novel therapies that target abnormal megakaryocytes to patients through this consortium.

PI_NAMEs: CRISPINO, JOHN D (contact)

PROJECT_TERMS: Abnormal megakaryocyte;Acute leukemia;Acute Myelocytic Leukemia;Affect;Animal Model;Automobile Driving;bench to bedside;Biology;Blast Phase;Blood Platelets;Bone marrow failure;Cell Cycle;Cells;Classification;Clinical Trials;Collaborations;cytokine;Cytokine Signaling;cytopenia;Data;Disease;Disease Progression;Doctor of Philosophy;driver mutation;Event;Evolution;experimental study;Fibrosis;GATA1 gene;Gene Expression;Goals;Hematopoiesis;hematopoietic stem cell quiescence;Hematopoietic stem cells;Heterogeneity;HIF1A gene;Human;Hyperplasia;IL4 gene;Immune;Immunofluorescence Immunologic;Impairment;In Vitro;in vivo;inhibitor;Interleukin-13;JAK2 gene;Knock-out;leukemia;Malignant - descriptor;Marrow;MDM2 gene;Megakaryocytes;Megakaryocytopoieses;mouse model;Mus;mutant mouse model;Mutation;Myelofibrosis;Myeloproliferative disease;neoplastic cell;neutralizing antibody;new therapeutic target;novel;Pathologic;Pathway interactions;Patient Recruitments;Patients;Phase II Clinical Trials;Phenotype;Play;Population;Primary Myelofibrosis;Proteins;receptor;Recording of previous events;Research;Resistance;response;ribosomopathy;Role;Signal Transduction;single-cell RNA sequencing;Splenomegaly;Symptom Burden;Symptoms;System;targeted treatment;Therapeutic Intervention;TP53 gene;Transforming Growth Factor beta;Transplantation;Visceromegaly;Work

PROJECT_TITLE: Project 2: Defining the Role of Megakaryocyte Abnormalities in the Progression of Primary Myelofibrosis


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Hodgkin's Disease;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Adoptive T cell therapy to treat human malignancies has been revolutionized by the use of chimeric antigen receptor (CAR) T cells in the past decade. However, the clinical success of this approach has been difficult to replicate for diseases other than acute lymphoblastic leukemia. We have pioneered the use of CD30.CAR-Ts to treat patients with relapsed/refractory Hodgkin Lymphoma demonstrating their antitumor effects. However, barriers still need to be overcome to further increase the response rate and long-term durability of complete responses of thse patients. Our proposal exploits major synergies between adoptive transfer of effector T cells, redirected and competitive T cell trafficking, and immune responses. If successful, our approach would alter the clinical practice of CAR-T cell based immunotherapies.

PI_NAMEs: SAVOLDO, BARBARA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Acute Lymphocytic Leukemia;Adoptive Cell Transfers;Adoptive Transfer;Affect;Antibodies;Antibody Therapy;Antigens;antitumor effect;Antitumor Response;Autologous;B lymphoid malignancy;Blood;cancer cell;CAR T cell therapy;CC chemokine receptor 4;CCL17 gene;CD19 gene;CD30 Antigens;Cell Death;Cell Therapy;Cells;Cellular immunotherapy;chemokine;chemokine receptor;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinical;clinical application;clinical practice;Clinical Research;Clonal Evolution;Combined Modality Therapy;Cross Presentation;Cutaneous T-cell lymphoma;cytokine release syndrome;Cytotoxic T-Lymphocytes;Development;Diffuse Large-Cell Lymphoma;Disease;disease model;Dose;effector T cell;engineered T cells;Engineering;Enrollment;Ensure;Epitope spreading;Evaluation;experience;fludarabine;Future;Generations;Hodgkin Disease;Homing;Human;Immune;Immune checkpoint inhibitor;immune function;Immune response;Immunomodulators;Immunosuppression;Immunotherapy;Impairment;improved;improved outcome;In complete remission;in vivo;Incidence;Individual;Infiltration;Inflammatory;inflammatory milieu;Infusion procedures;Institution;Lymphocyte Function;Lymphoid Cell;Lymphoma;Macrophage;Malignant Neoplasms;manufacture;Measures;Mediating;migration;Monitor;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;Nature;Non-Hodgkin's Lymphoma;overexpression;Patient-Focused Outcomes;Patients;Phase;Phase I Clinical Trials;Phase I/II Trial;Pre-Clinical Model;Production;receptor;recruit;Reed-Sternberg Cells;Refractory;Relapse;response;Retroviral Vector;Role;Shapes;Site;success;synergism;T cell therapy;T-Cell Lymphoma;T-cell receptor repertoire;T-Lymphocyte;Testing;TNFRSF8 gene;Toxic effect;trafficking;Treatment Failure;tumor;tumor microenvironment;tumorigenic;virtual

PROJECT_TITLE: Tailoring CAR T cell therapy for Hodgkin Lymphoma

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CHICAGO

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: This interdisciplinary program will train a diverse group of exceptional graduate students to become future leaders in 21st Century genetics research. Students will receive rigorous predoctoral research training from world-leading scientists in quantitative, computational, and experimental approaches to answer fundamental questions in molecular, statistical, and evolutionary genetics. The program will train 90 new Ph.D. scientists in 5 years to make major breakthroughs in understanding how genetic information affects biological systems in health and disease – essential knowledge to better diagnose, prevent, and treat a wide range of genetically-encoded conditions.

PI_NAMEs: NOVEMBRE, JOHN ;ROTHMAN-DENES, LUCIA B. B;RUTHENBURG, ALEXANDER JACKSON;THORNTON, JOSEPH W (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Evolution;Genetic

PROJECT_TITLE: Genetic Mechanisms and Evolution

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - A[TWD-A]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Data Science;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Physical frailty is common in adults with heart failure and increases the risk for poor health outcomes. Clinicians need tools to identify adults with physical frailty as part of routine care to support early intervention to treat frailty and reduce this risk. This application seeks to develop a novel measure of physical frailty using data collected as part of routine clinical care and recorded in the electronic health record.

PI_NAMEs: RAZJOUYAN, JAVAD  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Accident and Emergency department;Activities of Daily Living;Admission activity;Adult;advanced analytics;adverse outcome;Affect;Aging;aging related disease;American;analytical method;Award;Big Data;Biological Models;career;career development;Cessation of life;Chronic Disease;Clinical;clinical care;Clinical Data;clinical decision support;clinical decision-making;Clinical Informatics;Clinical Investigator;clinical practice;Clinical Research;Code;college;Complex;Computer Models;Congestive Heart Failure;Consensus;Data;Data Collection;Data Science;Data Scientist;Data Set;data warehouse;Databases;Decision Aid;Decision Making;deep neural network;Detection;Diagnosis;Early Intervention;Effectiveness;Elderly;Electronic Health Record;Environment;experience;Faculty;Foundations;Frail Elderly;frailty;Functional dependence;Functional impairment;functional status;Future;Goals;Guidelines;Health;Health Care Costs;Health Status;Heart failure;high risk;hospital readmission;Hospitalization;indexing;Individual;individual variation;innovation;International;Intervention;Laboratories;Length of Stay;Link;Machine Learning;Measures;Medicare;Medicare claim;Medicine;member;Mentors;Methods;Modeling;mortality;mortality risk;multidisciplinary;Natural Language Processing;novel;older adult;Older Population;Outcome;Outpatients;Patient Care;Patients;Pattern;Physiological;point of care;poor health outcome;Population;predictive modeling;Predictive Value;Prevalence;Procedures;prognostic value;Quality of Care;random forest;Reading;Recommendation;Records;Research;Research Project Grants;Risk;routine care;Safety;Scientist;screening;Series;signal processing;skills;Source;stressor;Structure;support tools;Survival Analysis;Symptoms;Syndrome;Techniques;Testing;Text;Time;tool;Training

PROJECT_TITLE: Using Large Electronic Health Records and Advanced Analytics to Develop Predictive Frailty Trajectories in Patients with Heart Failure

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(JA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PUBLIC HEALTH NARRATIVE The burden of cardiovascular disease is the highest in minority and socioeconomically disadvantaged communities. Lifestyle and behavioral interventions that have demonstrated effectiveness in improving blood pressure and medication adherence may not be available and accessible to individuals living in socioeconomically disadvantaged communities. Storytelling, peer health coaching, and web-based interventions are promising evidence-based approaches for promoting behavioral change. Combining these approaches may enhance the efficacy of an intervention and may offer a sustainable approach for promoting lifestyle change.

PI_NAMEs: CUFFEE, YENDELELA LEVANA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: acceptability and feasibility;Adherence;Affective;African American population;American Heart Association;Anti-Hypertensive Agents;Area;Attitude;Behavior;Behavior Therapy;Behavioral;Biomedical Research;Blood Pressure;blood pressure reduction;Cardiovascular Diseases;Caring;Chronic Disease;Clinical;Clinical Research;Clinical Sciences;Communities;Data;Delaware;design;Devices;Diastolic blood pressure;Education;Effectiveness;ethnic minority;Ethnic Population;evidence base;experience;Faculty;Family health status;Feasibility Studies;Federally Qualified Health Center;Feedback;Film;Funding;Goals;Group Meetings;Health;Healthcare;Home Blood Pressure Monitoring;Hour;Hypertension;hypertension control;improved;Individual;innovation;Intervention;K-Series Research Career Programs;Knowledge;Life Style;lifestyle intervention;Measures;medication compliance;Medication Management;member;men;Mentors;Minority;National Heart, Lung, and Blood Institute;neighborhood disadvantage;Online Systems;Outcome;Outcome Measure;Participant;Patient Self-Report;peer;personal narratives;Pharmaceutical Preparations;Public Health;racial minority;racial population;Randomized;recruit;Reporting;Research;research study;Resources;safety net;Side;Social support;socioeconomic disadvantage;Technology;technology intervention;Training;Translational Research;treatment as usual;Treatment Efficacy;Universities;uptake;Visit;web site;web-based intervention;Woman;Work

PROJECT_TITLE: Examining the Feasibility of Implementing a Hypertension Storytelling among African Americans with Hypertension


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Depression;Mental Health;Mental Illness;Neurosciences;Precision Medicine;Rehabilitation

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Social anxiety is a common and chronic problem but, for unknown reasons, many patients do not respond to existing treatments. Despite advances in neuroscience and computational psychiatry, there remains no reliable predictor of treatment response that can be used to select an optimal treatment for a given patient. The goals of the proposed research are to examine whether neuroimaging can offer an evidence-based precision or personalized medicine approach to predict treatment in patients with social anxiety, and to apply advanced computational and multimodal imaging approaches to improve our understanding of the neurobiology of social anxiety disorder, and brain changes (plasticity) associated with treatment response.

PI_NAMEs: DILLON, DANIEL G;GABRIELI, JOHN ;ROSELLINI, ANTHONY JOSEPH (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Adult;Behavior;behavior measurement;Behavioral;biomarker identification;Boston;Brain;brain circuitry;Chronic;Clinical;Clinical Data;clinical decision-making;clinical practice;cognitive control;Cognitive Therapy;Combined Modality Therapy;comparison control;connectome;cost;Data;Diffusion Magnetic Resonance Imaging;disease classification;Distress;Doctor of Philosophy;DSM-V;effective therapy;Electroencephalography;Emotional;evidence base;Face;Feedback;Functional disorder;Functional Magnetic Resonance Imaging;Goals;Group Therapy;Health;Hospitals;Human;Image;imaging approach;improved;improved outcome;Individual;Individual Differences;individual patient;Investigation;Left;Machine Learning;Magnetic Resonance Imaging;Massachusetts;Measurement;Measures;Mental disorders;Modeling;multimodal data;Multimodal Imaging;multimodality;Negative Valence;neural;neural circuit;Neurobiology;neuroimaging;neuromechanism;Neurosciences;optimal treatments;outcome prediction;partial response;Participant;Patient-Focused Outcomes;Patients;personalized medicine;Pharmacological Treatment;Positive Valence;precision medicine;predicting response;Prediction of Response to Therapy;predictive marker;predictive modeling;Process;Psychiatry;Psychopathology;Publishing;Recommendation;recruit;Reporting;Research;Research Domain Criteria;Research Personnel;response;Rest;reward processing;Sampling;Selective Serotonin Reuptake Inhibitor;Sertraline;Severities;skills;social anxiety;Social Anxiety Disorder;Source;Structure;success;System;systematic review;Technology;temporal measurement;Testing;Treatment Efficacy;treatment guidelines;Treatment outcome;treatment response;Universities;usability;Variant;white matter;Work

PROJECT_TITLE: Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Project Narrative Myelofibrosis (MF) is a chronic myeloproliferative neoplasm (MNP), which is primarily the consequence of intrinsic abnormalities occurring within hematopoietic stem and progenitor cells (HSPCs) associated with at least five events: 1) acquisition of MPN driver mutations leading to increased JAK/STAT signaling; 2) increased activation of NF-κB; 3) progressive downregulation of the tumor suppressor p53; 4) upregulation of components of the anti-apoptotic pathways and 5) upregulation of HIF1. These intrinsic MF HSPC abnormalities also lead to additional extrinsic events resulting in a chronic pro-inflammatory state and a dysregulated hematopoietic tumor microenvironment which favors the predominance of malignant HSPCs with increasing burdens of mutational and cytogenetic events. To test this hypothesis, combinations of drugs that upregulate p53 will be evaluated for their potential to disrupt the p53/NF-κB/HIF1 axis, deplete myelofibrosis HSPCs as well as disarm their supportive TME prior to their subsequent evaluation in clinical trials.

PROJECT_TERMS: Abnormal Cell;antagonist;Apoptotic;Blast Phase;Bromodomain;cancer cell;Cells;chemokine;Chromatin;Chromosome abnormality;Chronic;Clinical;Clinical Trials;Complex;Cytogenetics;cytokine;Development;Disease;Disease Progression;Disease remission;disorder risk;Down-Regulation;driver mutation;Drug Combinations;Endothelial Cells;Epigenetic Process;Evaluation;Event;Evolution;Fibrosis;gastrointestinal;Gene Frequency;Gene Mutation;Generations;genetic architecture;genetic variant;Hematopoiesis;Hematopoietic;Hematopoietic Neoplasms;Hematopoietic stem cells;HIF1A gene;improved;Inflammatory;inflammatory milieu;inhibitor therapy;Interruption;JAK1 gene;JAK2 gene;Malignant - descriptor;Marrow;MDM2 gene;Megakaryocytes;Mesenchymal Stem Cells;Metabolic;Molecular;multicatalytic endopeptidase complex;Mutate;Mutation;mutational status;Myelofibrosis;Myelogenous;Myeloproliferative disease;Natural History;nutlin 3;overexpression;Pathway interactions;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phosphoric Monoester Hydrolases;Polycomb;Production;Protein Dephosphorylation;protein expression;Protein Overexpression;Protein phosphatase;Proteins;Quality of life;recruit;Reducing Agents;Regimen;Repressor Proteins;Research;Role;Signal Transduction;stem cell exhaustion;stem cells;Symptoms;targeted treatment;Testing;Therapeutic;Toxic effect;TP53 gene;tumor microenvironment;Tumor Suppression;Tumor Suppressor Proteins;Up-Regulation

PROJECT_TITLE: Project 3: Development of Strategies to Deplete Myelofibrosis Stem Cells


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE Mitochondrial dysfunction and cellular energy deficits have emerged as hallmarks of aging-associated disorders. In this project, we aim to measure the effect of nicotinamide riboside (NR) on brain energy metabolism in patients with mild cognitive impairment and Alzheimer’s disease. Specifically, we will use novel MR spectroscopy techniques to investigate and validate NR target engagement in vivo in the brain, as well as explore the cognitive and functional effects of NR supplementation in this patient population.

PI_NAMEs: DU, FEI  (contact);FORESTER, BRENT PETER

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: Acceleration;Achievement;Address;Affect;Age;age related;age related decline;Age-associated memory impairment;age-related disease;Aging;aging process;aging related;aging related disease;Alzheimer's Disease;Alzheimer's disease patient;Amyloid;Animals;Antioxidants;ATP phosphohydrolase;Bioenergetics;Biological Availability;Biological Process;Brain;Brain imaging;Cell Line;Cell Survival;cerebrovascular;Cerebrum;Circadian Rhythms;Clinical assessments;clinical effect;Clinical Trials;Cognition;Cognitive;cognitive function;Consumption;Creatine Kinase;Custom;daily functioning;Data;Dedications;design;Development;Disease;Early Diagnosis;effective therapy;Electron Transport;Energy Metabolism;Equilibrium;Foundations;Free Radicals;Functional disorder;functional improvement;functional independence;Glucose;Glutathione;Goals;hallmarks of aging;Healthcare Systems;Human;imaging approach;Imaging Techniques;improved;In Vitro;in vivo;indexing;Individual;Inflammation;innovation;interest;Literature;Magnetic Resonance Spectroscopy;Measurement;Measures;Medial;Mediating;Metabolic;Metabolism;mild cognitive impairment;Mitochondria;mitochondrial dysfunction;Molecular;NADH;neural repair;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neuroimaging;neuroinflammation;Neuronal Dysfunction;Nicotinamide adenine dinucleotide;nicotinamide riboside supplementation;nicotinamide-beta-riboside;normal aging;novel;novel strategies;open label;Oral;Oral Administration;Oxidation-Reduction;Oxidative Stress;patient population;Patients;Phase I Clinical Trials;Prefrontal Cortex;Production;Publishing;remediation;repaired;Resistance;response;RF coil;Scanning;Schizophrenia;Signaling Molecule;standardize measure;Stress;Supplementation;Techniques;Testing;therapeutic target;treatment strategy;United States;Veins

PROJECT_TITLE: Effects of Orally Administered Nicotinamide Riboside on Bioenergetic Metabolism, Oxidative Stress and Cognition in Mild Cognitive Impairment and Mild Alzheimer's Dementia


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_DEPT: OTOLARYNGOLOGY

PHR: Project Narrative Research training in hearing and balance requires a wide range of experimental and theoretical knowledge. This training program brings together experts from molecular genetics to population health to produce the next generation of scientists addressing these all-important senses. The gradual decrement of hearing and balance in our increasingly aged population makes this effort especially meaningful.

PI_NAMEs: CULLEN, KATHLEEN E (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Equilibrium;Hearing;programs

PROJECT_TITLE: Trainging Program in Hearing and Balance


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: AMES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: PROJECT NARRATIVE This project will contribute to public health through developing recommendations for prioritized alternatives to antibiotics to manage diseases in major livestock species in order to reduce the use of antibiotics in food- producing animals. Bacteria that are resistant to antibiotics are a growing threat to public health and to food security and safety. Reducing antibiotic use in food-producing animals decreases the selection pressure for the emergence and spread of antimicrobial resistant bacteria in the environment and in areas where humans and animals interact, and supports antibiotic efficacy being preserved into the future.

PI_NAMEs: KARRIKER, LOCKE ANDERSON (contact)

PROGRAM_OFFICER_NAME: HUEBNER, KATHERINE

PROJECT_TITLE: Integration of a multi-pronged standardized methodology to identify key diseases and prioritized antimicrobial alternatives in production animals


PHR: Narrative – Overall MNORC Obesity is a critical health problem that contributes to a wide range of health problems and healthcare costs. Obesity has also defied easy treatment. The Michigan Nutrition Obesity Research Center will provide researchers the opportunity to utilize advanced technologies and computational tools to understand how causes of obesity vary among individuals and across the population. Through these efforts, health professionals will be able to translate these lessons to the design and implementation of novel dietary, exercise and medication interventions to control obesity and obesity- related diseases in both adults and children.

PI_NAMEs: SEELEY, RANDY J (contact)

PROGRAM_OFFICER_NAME: EVANS, MARY

PROJECT_TERMS: Academic support;Address;Adipocytes;Adipose tissue;Adult;analytical tool;Area;Award;base;Basic Science;biobehavior;Caring;cell type;Child;Child Nutrition;Childhood;Clinical;clinical care;Clinical Research;clinical translation;Collaborations;Communication;Communities;computerized tools;Data;Data Analytics;data integration;design;dietary;Dietary Intervention;Direct Costs;Discipline;Disease;Education;educational atmosphere;Environment;Exercise;Faculty;Family;Funding;Genomics;Goals;Grant;Health;Health Care Costs;health information technology;Health Professional;Health system;Healthcare;House Staffs;Human;human subject;improved;Individual;Industry;Infrastructure;Inpatients;insight;Institution;interest;Intervention;Investments;Knowledge;Laboratories;Learning;Medical Students;member;Metabolic;metabolomics;Methodology;Michigan;Mission;molecular phenotype;Mothers;Multiomic Data;neurobehavioral test;novel;Nutrient;nutrition;Obesity;Obesity associated disease;obesity in children;obesity treatment;Outpatients;overweight child;Patients;Pharmaceutical Preparations;Phenotype;phenotypic data;Population;population based;Population Characteristics;Population Research;pre-clinical research;preclinical study;pregnant;Productivity;programs;Public Policy;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;response;Schools;Series;Services;Source;Students;symposium;Technology;Testing;Tissues;tool;Training;Training and Education;training opportunity;transcriptomics;Translating;Translational Research;undergraduate student;Universities;weight loss program;Weight maintenance regimen;Woman


PROJECT_TERMS: Administrator;Advisory Committees;Agreement;Area;base;Clinical;clinical care;Clinical Research;Communities;Consultations;Cost Sharing;Doctor of Philosophy;Education;Ensure;Environment;Epidemiology;Evaluation;Expenditure;Faculty;Funding;Goals;Grant;Health Personnel;Health Services;Informatics;interest;meetings;member;metabolic phenotype;Michigan;molecular phenotype;National Institute of Diabetes and Digestive and Kidney Diseases;nutrition;Nutritional Study;Obesity;operation;Output;Population Study;pre-clinical;programs;recruit;Reporting;Reproducibility;Research;Research Personnel;Resources;Students;Surveys;symposium;Training;United States National Institutes of Health;Universities;University resources;web site;Weight maintenance regimen;working group

PROJECT_TITLE: Michigan Nutrition Obesity Research Center


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Nutrition;Obesity;Pediatric;Physical Activity;Prevention

PI_NAMEs: HOROWITZ, JEFFREY F (contact)

PROJECT_TERMS: Accelerometer;Adipose tissue;Adult;Aerobic Exercise;Anthropometry;Area;Behavior;Biopsy;Blood;Blood Pressure;Body Composition;Cardiometabolic Disease;Child;Chronic;Clinical;clinical phenotype;Clinical Research;community setting;Consult;Consultations;Consumption;Data Set;design;Development;dietary;Dietary Intervention;Disease;Dual-Energy X-Ray Absorptiometry;Educational Intervention;Energy Metabolism;Ensure;Exercise;exercise intervention;exercise training;Fasting;Glucose Clamp;Goals;Human;Human Resources;human subject;Hyperinsulinism;Infrastructure;Inpatients;insight;Intervention;Intervention Trial;Isotopes;Laboratories;laboratory experiment;Measurement;Metabolic;metabolic abnormality assessment;metabolic phenotype;Methodology;Methods;Michigan;Muscle;new technology;nutrition;Nutrition Assessment;Nutritional;Obesity;Obesity associated disease;obesity in children;obesity treatment;oral glucose tolerance;organizational structure;Outpatients;Participant;Patient Self-Report;Phenotype;Physical activity;Physical assessment;Physical Exercise;Physiological;population based;Procedures;Protocols documentation;Reproducibility;Research;Research Design;Research Personnel;Research Support;Research Training;response;Rest;satisfaction;Services;skeletal tissue;Standardization;Structure;Supervision;Techniques;Testing;testing services;Tissue Banks;tool;Tracer;translational study;Work

PROJECT_TITLE: Nutrition, Exercise and phenotype Testing Core


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: NARRATIVE – PROJECT 4 The overall goal of this project is to directly translate therapies originating from therapeutic targets identified from scientific Projects 1-3 into novel treatment strategies targeting the myeloproliferative neoplasm (MPN) hematopoietic stem cell (HSC) and the supportive microenvironmental abnormalities in patients with myelofibrosis (MF). Such therapies will be evaluated in investigator-initiated, early developmental phase, clinical trials with agents derived from the scientific Projects (1-3) and designed to deplete the MPN HSC through direct anti- clonal activity and modification of the impaired microenvironment, thereby favorably altering the natural history of disease.

PI_NAMEs: MASCARENHAS, JOHN  (contact)

PROJECT_TERMS: Aggressive Clinical Course;antagonist;Biological Assay;Biological Markers;Blood;Bone Marrow;Bone Marrow Cells;Bromodomains and extra-terminal domain inhibitor;Cessation of life;Clinical;Clinical Trials;Clinical Trials Cooperative Group;design;Development;Disease;disease natural history;Disease Progression;Disease remission;Doctor of Philosophy;early phase clinical trial;Evolution;experimental study;Focus Groups;Funding;Future;Goals;Hematopoiesis;Hematopoietic stem cells;high risk;Impairment;improved;improved outcome;In Vitro;in vivo;Infrastructure;inhibitor;Investigation;JAK2 gene;Malignant - descriptor;MDM2 gene;member;Modification;Molecular;Molecular Conformation;Mutation;Myelofibrosis;Myeloproliferative disease;Natural History;novel;novel therapeutic intervention;participant enrollment;Pathogenicity;Pathologic;Pathway interactions;Patients;peripheral blood;Phase;Philadelphia Chromosome;Phosphotransferases;Primary Myelofibrosis;Program Research Project Grants;Prospective Studies;Publishing;Research;Research Personnel;Resistance;response;restoration;Safety;Sampling;Signal Transduction;Specimen;Splenomegaly;stem cell exhaustion;stem cell population;success;Symptoms;System;Testing;Therapeutic;therapeutic development;therapeutic target;therapy resistant;Tissues;TP53 gene;Translating;Translational Research;Treatment outcome;treatment response;treatment strategy

PROJECT_TITLE: Project 4: MPN Clinical Consortium


ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Cardiometabolic diseases and consequences afflict more Americans, especially minority populations, than all others combined. The understanding of how to deal with this major health problem is critical for the future of America. The current proposal outlines a new training opportunity to prepare early career individuals in the conduct of basic, clinical, and translational cardiometabolic research in a comprehensive, multi-disciplinary fashion.

PI_NAMEs: STEPP, DAVID W (contact);SULLIVAN, JENNIFER C

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Multi-Disciplinary Training Program in the Mechanisms of Cardiometabolic Disease

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Nutrition;Obesity

PI_NAMEs: MACDOUGALD, ORMOND A (contact)

PROJECT_TERMS: Acceleration;Address;Adipocytes;Adipose tissue;Animal Model;Applications Grants;Biological Assay;Biology;Biopsy;Blood Vessels;Bone Marrow;cell type;Cells;Clinical;Clinical Investigator;Collection;Complex;Consultations;Core Facility;cost;Data;Data Collection;Data Set;Databases;Dietary Intervention;Effectiveness;Endocrine;Ensure;Equipment;experience;Experimental Designs;experimental study;Fibroblasts;Flow Cytometry;Funding;Funding Agency;Gene Modified;Genes;Genomics;Goals;Histologic;Human;human data;Human Resources;Immune;improved;Individual;Inflammatory;insight;Interdisciplinary Study;interest;Investigation;Knowledge;Leukocytes;Lipids;Location;Measures;Mesenchymal;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolism;Methodology;Methods;Michigan;microCT;Modeling;Molecular Biology;molecular phenotype;mouse model;Mus;new technology;Nuclear RNA;Nutrient;nutrition;Obesity;paracrine;Pathway interactions;pre-clinical;Reagent;Reproducibility;Research;Research Personnel;research study;Research Technics;Resources;Rodent;Role;Sampling;sequencing platform;Services;sex;single cell genomics;single cell sequencing;Source;stem cells;Study models;synergism;Techniques;Technology;Tissue Expansion;tissue processing;Tissues;tool;Training;transcriptome sequencing;United States National Institutes of Health;Update;Work

PROJECT_TITLE: Adipose Tissue Core


NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Services;Nutrition;Obesity;Patient Safety;Pediatric;Prevention;Primary Health Care

PI_NAMEs: LEE, JOYCE  (contact)

PROJECT_TERMS: Address;Adolescence;Area;Behavioral;biobank;Blood Screening;Body mass index;Centers for Disease Control and Prevention (U.S.);Child;Child health care;Childhood;Chronic Disease;Classification;Clinic;Clinical;cohort;Collaborations;Collection;Communities;comparative effectiveness study;Consultations;Data;data access;Data Analyses;Data Set;design;Development;digital repositories;Eating Behavior;Ecosystem;Electronic Health Record;Etiology;evidence base;fatty liver disease;Funding;Geography;Goals;Growth;Health;health care delivery;health data;health information technology;Health system;hypercholesterolemia;Hypertension;improved;improved outcome;Infant;Infrastructure;innovation;Institutional Review Boards;interest;International;Intervention;Intervention Studies;Longitudinal cohort;Maternal Health;Medicine;member;Michigan;Neonatal;Neonatal Screening;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;nutrition;Obesity;obesity in children;Observational Study;Outcome;Outcomes Research;outreach;patient engagement;Patient Outcomes Assessments;Patients;Policies;Population;Positioning Attribute;Prevention;Primary Care;Productivity;prospective;Provider;Public Health Practice;recruit;repository;Research;Research Design;Research Infrastructure;Research Personnel;Research Support;Resources;Risk Factors;secondary analysis;Services;social health determinants;Specimen;Spottings;System;Time;tool;Translational Research;translational scientist;treatment and outcome;trend;Universities;Weight;Work

PROJECT_TITLE: Childhood Obesity Research Core


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Digestive Diseases;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Inflammatory Bowel Disease;Microbiome

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Coronavirus disease 2019 (COVID-19) has infected millions, impacted billions of lives, and precipitated socioeconomic destabilization. There is a pressing need to understand SARS-CoV-2 replicates in the host gastrointestinal tract, interacts with the mucosal immune system, and drives diarrheal disease. We expect our results to drive innovative therapeutics to treat COVID-19 related enteric diseases with or without inflammatory bowel diseases.

PI_NAMEs: CIORBA, MATTHEW AARON (contact);DING, SIYUAN

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: 16S ribosomal RNA sequencing;2019-nCoV;Abdominal Pain;ACE2;Acute;acute infection;Address;Affect;bile salts;biobank;Biology;Cathepsin L;Cell Death;Cells;Chronic;Clinical;Colitis;Colon;Coronavirus;COVID-19;COVID-19 patient;COVID-19 severity;COVID-19 treatment;COVID-19 vaccination;Crohn's disease;Data;Diarrhea;diarrheal disease;differential expression;Disease;Endosomes;Enteral;enteric infection;Enterocytes;Environmental Risk Factor;Epithelial Cells;Epithelium;Etiology;experience;Feces;Functional disorder;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal infection;Gastrointestinal Physiology;gastrointestinal symptom;Gastrointestinal tract structure;Genetic;Genotype;gut dysbiosis;gut inflammation;gut microbiome;Health;Homeostasis;Household;Human;Immune;Immune response;Immunology;Impairment;Infection;infection rate;Inflammation;Inflammatory Bowel Diseases;inhibitor;Injections;innovation;Integration Host Factors;Intestinal Diseases;intestinal epithelium;Intestines;Investigation;Knowledge;Liquid substance;Lower Gastrointestinal Tract;microbiome;microbiome therapeutics;microbiota;Modeling;Molecular;mouse model;Mucosal Immune Responses;Mucosal Immune System;Mucositis;Mucous Membrane;Mus;Nausea;novel;novel coronavirus;novel strategies;Observational Study;Organ;Organoids;Outcome;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Phenotype;Populations at Risk;Reporter;respiratory;Respiratory System;Role;SARS-CoV-2 B.1.617.2;SARS-CoV-2 infection;SARS-CoV-2 P.1;SARS-CoV-2 variant;Severity of illness;Shapes;Signal Transduction;Site;Small Intestines;socioeconomics;Specimen;stool sample;Symptoms;Systemic disease;Testing;Therapeutic;Therapeutic immunosuppression;tool;Transgenic Mice;Tropism;Viral Load result;Viral reservoir;virology;virome;Virus;virus resource;Vomiting

PROJECT_TITLE: Mechanisms of Gastrointestinal COVID-19

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


PI_NAMEs: PENNATHUR, SUBRAMANIAM  (contact)

PROJECT_TERMS: Acyl Coenzyme A;Address;Adipocytes;Amino Acids;analytical tool;Animals;Area;Basic Science;Bioinformatics;bioinformatics tool;Biological;Biological Assay;biological systems;biomarker identification;Carnitine;Cells;Ceramides;Chromatography;Clinical;Clinical Research;Collaborations;Complex;Consultations;Consumption;cost effectiveness;Cost Measures;Coupled;Cultured Cells;Data;Data Analyses;Data Analytics;data integration;data pipeline;Data Set;detection method;Development;Disease;Electrospray Ionization;Equipment;Exercise;Fatty Acids;Funding;Gas Chromatography;Gene Expression;Genus Hippocampus;Glycolysis;graduate student;High Pressure Liquid Chromatography;high throughput screening;Human Resources;human subject;human tissue;In Vitro;in vivo;Infrastructure;innovation;insight;instrument;interest;Label;Laboratories;large datasets;Libraries;lipidomics;Lipids;Liquid Chromatography;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Methods;Michigan;Mitochondria;Modeling;Molecular;Molecular Analysis;molecular phenotype;Multiomic Data;Mus;Network-based;novel;Nucleic Acids;nutrition;Nutrition Disorders;Nutritional Study;Obesity;obesity in children;Phenotype;Phospholipids;Physiological;Plasma;Postdoctoral Fellow;pre-clinical;Procedures;Process;Production;programs;Protocols documentation;Protons;Research;Research Personnel;Respiration;response;Rodent;Sampling;Sensitivity and Specificity;Services;Shotguns;skills;small molecule;stable isotope;Standardization;stem;Surveys;System;Techniques;Technology;temporal measurement;Testing;Time;Tissues;Training;Trans Fatty Acids;Translational Research;Urine;Visualization;Weight maintenance regimen

PROJECT_TITLE: Molecular Phenotyping Core


NIH_SPENDING_CATS: Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

PHR: Project Narrative Ovarian cancer causes more deaths than any other gynecologic cancer, largely due to late stage at diagnosis and frequent treatment failures. In this proposal we expand on our initial findings that ovarian cancers are sensitive to ferroptosis, a novel iron-dependent form of cell death, by examining new enzymes and pathways that modify ferroptosis, finding where in the cell iron triggers the ferroptotic death signal, and examining how certain cells that surround the ovarian cancer affect the extent to which ovarian cancer can be killed by drugs that induce ferroptosis. These experiments may ultimately pave the way for more effective use of ferroptosis- inducing drugs in ovarian cancer therapy.

PI_NAMEs: TORTI, SUZY V (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: addiction;advanced disease;Affect;anti-cancer;Antineoplastic Agents;cancer cell;Cancer Etiology;Cancer Patient;cancer stem cell;cancer therapy;Cell Culture Techniques;Cell Death;Cell Death Signaling Process;Cells;Cessation of life;CREB1 gene;Data;defined contribution;desaturase;Enzymes;Epithelial ovarian cancer;Event;experimental study;Exposure to;Fibroblasts;Fostering;Generations;Genes;Genetic Transcription;Goals;Grant;Growth;heme oxygenase-1;Homeostasis;Image;improved;in vivo;innovation;insight;Investigation;Iron;Iron Chelation;iron metabolism;Knowledge;Laboratories;LCN2 gene;Link;lipid metabolism;Lipid Peroxidation;Lipid Peroxides;Lipids;Macrophage;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mediating;mouse model;Names;Neoplasm Metastasis;neoplastic cell;Non-Malignant;novel;novel strategies;Organelles;ovarian neoplasm;oxidized lipid;palliative;paracrine;Pathway interactions;patient prognosis;Pharmaceutical Preparations;Pilot Projects;Play;polyunsaturated fat;Precision Run-On Sequencing;Predisposition;Proteins;Publishing;Regulatory Pathway;response;Role;Signal Pathway;Signal Transduction;Site;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Stage at Diagnosis;successful intervention;Testing;three dimensional cell culture;transcription factor;Transcriptional Activation;Treatment Failure;tumor;tumor initiation;tumor microenvironment;Tumor-associated macrophages

PROJECT_TITLE: Iron, Ferroptosis and Ovarian Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


PI_NAMEs: SANDOVAL, DARLEEN A. (contact)

PROJECT_TERMS: Acceleration;Advertisements;Area;Award;Behavioral;Biological;career;Clinical;Collaborations;college;Cost Sharing;Data;Diabetes Mellitus;Disease;disorder risk;Doctor of Philosophy;Eligibility Determination;Ensure;Equity;Evaluation;Event;Expenditure;Funding;Funding Agency;Funding Opportunities;Goals;Grant;Grant Review;Individual;innovation;interest;Intervention;Investments;Knowledge;member;Mentors;Metabolism;metabolomics;Michigan;mid-career faculty;Mission;Monitor;Nutrient;nutrition;Obesity;Operative Surgical Procedures;Paper;Population;programs;Publications;Publishing;recruit;Research;Research Personnel;Schools;success;United States National Institutes of Health;Universities

PROJECT_TITLE: Pilot and Feasibility


PHR: CORE A Narrative Core Lead: Ronald Hoffman, MD The Administrative Core of this Program Project is designed to provide scientific leadership, effective communication and an administrative support structure, and to ensure the collaborative translational research network that supports and synergizes the laboratory and clinical studies led by MPN-RC investigators is maintained. The essential services provided by the Core include, but are not limited to: administrative support for all of the investigators in each project and core; fiscal management and oversight for all components of the Program Project; and organization and communication of all Program Project meetings and activities. Additionally, the Core will work with various foundation and MPN patient community groups to disseminate updates on MPN research and treatment.

PI_NAMEs: HOFFMAN, RONALD  (contact)

PROJECT_TERMS: Accountability;Address;Budgets;Clinical Investigator;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;Competence;Contracts;design;Development;Educational Activities;Ensure;Equipment;Equipment and Supplies;Financial Support;Foundations;Funding;Geographic Locations;Goals;Human Resources;human subject;Infrastructure;Institution;Laboratory Study;Lead;Leadership;Mediation;meetings;member;Monitor;Myeloproliferative disease;Occupational activity of managing finances;Organization and Administration;patient advocacy group;Patients;Performance;Personnel Management;Pharmaceutical Preparations;Pharmacologic Substance;Process;programs;Progress Reports;Regulation;Research;Research Personnel;Resource Allocation;Resource Sharing;Resources;Schedule;Services;Site;Structure;support network;synergism;Translational Research;United States National Institutes of Health;Update;Vertebrates;Visit;web site;Work

PROJECT_TITLE: Core A: Administrative Core


PI_NAMEs: PETERSON, KAREN EILEEN (contact)

PROJECT_TERMS: Address;Adipose tissue;base;Basic Science;Biochemical;Biomedical Research;Child Nutrition;Clinical;Clinical Nutrition;Clinical Research;Collaborations;Communication;Communities;Data;data access;Data Collection;Development;Dietetics;Discipline;Educational workshop;Ensure;Epidemiology;Exercise;Exposure to;Fostering;Functional disorder;Funding Opportunities;Future;Goals;graduate student;Grant;Health Professional;Human;innovation;insight;Internships;Intervention;Kinesiology;Laboratories;Laboratory Research;Learning;Link;Measurement;Medical Students;meetings;member;metabolomics;Michigan;Molecular;next generation;nutrition;Nutrition Assessment;Nutritional Science;Obesity;obesity in children;Participant;Phenotype;population health;Population Research;post-doctoral training;Postdoctoral Fellow;posters;precision nutrition;profession allied to medicine;programs;Protocols documentation;Public Health;Public Health Schools;Publications;recruit;Reproducibility;Research;Research Design;Research Methodology;Research Personnel;Research Technics;Resources;Rotation;Schools;Science;Series;Service provision;Services;Standardization;Statistical Data Interpretation;Students;symposium;technology/technique;Testing;tool;Training;Translational Research;undergraduate student;Universities;web site;Weight maintenance regimen

PROJECT_TITLE: Enrichment Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative Alzheimer’s disease is one of the major health and economic challenges of our time. There is an urgent need to understand the structurally polymorphic nature of amyloids with different structures accumulating in different neurodegenerative diseases and their subtypes. We have assembled a world class team of pathologists, biochemists, biophysicists and structural biologists to purify, structurally characterize and replicate homogeneous samples of the polymorphic brain amyloids and distribute them to researchers along with reagents and protocols to identify, quantify and authenticate them in vitro and in vivo.

PI_NAMEs: GLABE, CHARLES G. (contact);HEAD, ELIZABETH

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta oligomer;Adopted;Affect;Alzheimer's Disease;Amino Acid Sequence;Amyloid;Amyloid beta-Protein;Amyloid Fibrils;amyloid imaging;amyloid structure;analytical tool;Antibodies;Basic Science;beta pleated sheet;Binding;Biological;Brain;Cryoelectron Microscopy;Data;Development;Diagnosis;Disease;disorder subtype;Dyes;Economics;familial Alzheimer disease;Fluorescence;Fluorescent Dyes;Fluorescent Probes;fluorophore;Genetic Polymorphism;Goals;Health;Heterogeneity;Human;In Vitro;in vivo;Individual;interest;Methods;Molecular Conformation;Monoclonal Antibodies;monomer;Nature;Neurodegenerative Disorders;Pathogenesis;Pathologic;Pathologist;Peptides;Persons;Play;Polymorph;Population;Preparation;Production;Property;Protocols documentation;Publications;Reaction;Reagent;Recombinants;Reproducibility;Research;Research Personnel;Resource Sharing;Resources;Role;Sampling;Series;Serum;Source;Stains;Standardization;Structural Biologist;structural biology;Structure;Testing;Time;tool;Transgenic Organisms;Variant

PROJECT_TITLE: Shared resource to develop tools and reagents to study structural polymorphisms in Abeta amyloid aggregates in AD


NIH_SPENDING_CATS: Cancer;Hematology;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: Core B Project Narrative The Core B Tissue Bank is an essential resource of the Myeloproliferative Neoplasms-Research Consortium (MPN-RC) which receives, processes and stores tissues collected from MPN patients consented under IRB approved Protocol 106 (Project 4), as well as patients on Project 4 clinical trials. Core B provides a central repository for these tissues that are associated with clinical and mutational annotation (Core C), which enables appropriate selection of specimens for each project. Specimens are distributed to MPN-RC investigators and the larger scientific community for translational research and clinical trial specimens are utilized for biomarker and pharmacodynamic analysis of novel therapies (Core D).

PI_NAMEs: MARCELLINO, BRIDGET KELLY (contact)

PROJECT_TERMS: accurate diagnosis;Automobile Driving;Bioinformatics;Biological Markers;Biometry;Clinical;Clinical Data;clinical research site;Clinical Trials;Communities;Consent;Cryopreservation;Data;data management;data repository;Dedications;Doctor of Philosophy;Drug or chemical Tissue Distribution;Effectiveness;effectiveness evaluation;Enrollment;Equipment and supply inventories;Hematopoietic stem cells;Individual;individual patient;Infrastructure;Innovative Therapy;Institution;Institutional Review Boards;Lead;Link;member;Mutation;Myeloproliferative disease;novel;novel therapeutic intervention;novel therapeutics;Online Systems;participant enrollment;Pathogenesis;Patient Participation;Patients;Pharmacodynamics;Process;Protocols documentation;repository;Research;Research Personnel;Research Project Grants;Resistance;Resource Sharing;Resources;Specimen;stem cells;Therapeutic;therapy development;Tissue Banks;Tissues;Translational Research;treatment response

PROJECT_TITLE: Core B: MPN-RC Tissue Bank


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Stem Cell Research;Stem Cell Research - Embryonic - Human;Traumatic Head and Spine Injury

ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Efforts to promote recovery of function after human spinal cord injury (SCI) will likely require interventions targeting the corticospinal motor system, the most important pathway for voluntary motor control in humans. This work will expand our knowledge of the primate transcriptional state after SCI, identify potentially optimal time points for therapeutic intervention, and allow enrichment of neural stem cell grafts with cell types that constitute the best means of forming new functional relays across sites of severe SCI.

PI_NAMEs: TUSZYNSKI, MARK H. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Adult;Affinity Chromatography;Axon;axon injury;axon regeneration;Brain;cell type;Cells;Cervical spinal cord structure;connectome;Corticospinal Tracts;critical period;Data;Distal;Embryo;functional improvement;Genes;Genetic Transcription;Grant;Growth;Hand;Human;improved;injured;Injury;Interneurons;Intervention;Knowledge;Label;Lesion;Macaca mulatta;Monkeys;Motor;motor control;Motor Cortex;Motor Neurons;Mus;Natural regeneration;Nature;nerve stem cell;neural;neural graft;Neurons;novel;Pathway interactions;Primates;programs;Property;Rattus;Recovery of Function;Recovery Support;regenerative;Reporting;Ribosomes;RiboTag;Rodent;Series;severe injury;Site;Spinal Cord;Spinal cord injury;stem cells;Synapses;System;Therapeutic Intervention;Time;time use;transcriptome;transcriptome sequencing;Translations;Up-Regulation;Viral;Viral Vector;Work

PROJECT_TITLE: The Primate Corticospinal Connectome and Transcriptome

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

PHR: CORE C Project Narrative The Biostatistics and Data Management Core will provide the Myeloproliferative Neoplasms Research Consortium (MPN-RC) investigators access to state-of-the-art integrated statistical and data management resources. It provides a mechanism for consistent and compatible data handling and tracking among the projects and cores and ensures the work across the MPN-RC is accomplished in a timely manner with the utmost statistical rigor. Providing oversight of all MPN-RC related statistical and data management activities through this Core allows for synergies and efficiencies for systematic and programmatic initiatives beyond what can be achieved with individual statistical teams for each project.

PI_NAMEs: DUECK, AMYLOU CONSTANCE (contact)

PROJECT_TERMS: arm;Bioinformatics;Biological Markers;Biological Specimen Banks;Biometry;Case Report Form;Clinic;Clinical;Clinical Data;Clinical Investigator;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Collaborations;Communication;Competence;Correlative Study;Coupled;dashboard;Data;Data Analyses;Data Collection;Data Element;data handling;data integration;data management;Data Management Resources;data quality;data repository;data standards;data visualization;design;Doctor of Philosophy;early phase clinical trial;Electronics;Ensure;experience;Experimental Designs;Formulation;Funding;Grant;Hematologic Neoplasms;Individual;Infrastructure;International;Investigational Drugs;Laboratories;Laboratory Study;Leadership;meetings;Monitor;multidimensional data;Myeloproliferative disease;Online Systems;Outcome Study;Participant;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Process;programs;Progress Reports;Protocols documentation;Publishing;Questionnaires;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Safety;Specimen;Statistical Data Interpretation;Statistical Models;synergism;Techniques;Time;Tissue Banks;Tissues;tool;Training;Translational Research;translational scientist;translational study;Tumor Bank;United States Food and Drug Administration;Validation;web platform;web site;Work

PROJECT_TITLE: Core C: Biostatistics and Data Management Core


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Mutation is the driver of evolution, the root of heritable diseases, and the initiator of tumors. Despite its direct relevance to human health and evolution, we understand little about why mutation does not happen at the same rate at all sites across the genome. We will apply novel computational methods to genomic and epigenomic data from various sources to investigate the molecular mechanisms behind mutation rate variation across the genome, as well as its functional, evolutionary, and practical consequences.

PI_NAMEs: GAO, ZIYUE  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Computing Methodologies;Cytosine;Data;Dependence;Disease;epigenomics;Evolution;Gene Frequency;Generations;Genes;Genetic Models;genetic variant;Genetic Variation;Genome;genome sequencing;genome-wide;genomic data;Genomics;Goals;Health;Heritability;Human;human data;Human Genome;improved;innovation;insight;Lesion;Machine Learning;Malignant Neoplasms;Methods;Methylation;Molecular;Mutation;novel;Population;Population Genetics;Process;programs;repaired;Reproduction;Research;Signal Transduction;Site;Somatic Cell;Somatic Mutation;Source;Specificity;Statistical Data Interpretation;Techniques;Tissues;Translating;tumor;tumorigenesis;Variant

PROJECT_TITLE: Mechanisms and consequences of sequence context-dependency of human mutation rate

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-S(55)R]