ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Public Health Relevance  The development and application of chemical tools in relevant human disease models can provide insights into the molecular mechanisms of disease development and progression. This proposal leverages novel chemical tools to understand fundamental disease processes, thereby impacting public health.

PI_NAMEs: STAINS, CLIFF I (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: Biological;Cell Physiology;Cells;Chemicals;Communication;Development;Disease;disease model;enzyme activity;Event;Fluorescent Probes;fluorophore;Goals;human disease;insight;Molecular;molecular assembly/self assembly;Monitor;novel;Organism;Pathway interactions;Process;Proteins;Public Health;public health relevance;response;Signal Transduction;Signaling Molecule;small molecule;System;Technology;Time;tool;Work

PROJECT_TITLE: Chemical Approaches for Interrogating Fundamental Biomedical Processes


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Boulder

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOCHEMISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRARTIVE We are using a basic biology approach grounded in host-pathogen interactions to discover new compounds that disrupt the infection process. This represents the earliest possible stage of antibiotic discovery and relies upon bacterial cell physiology, in vitro, and in vivo infection models to identify workable new research directions.

PI_NAMEs: DETWEILER, CORRELLA S (contact)

PROGRAM_OFFICER_NAME: ALEXANDER, WILLIAM A

PROJECT_TERMS: Affect;Animals;Anti-Bacterial Agents;Antibiotics;antimicrobial;Antimicrobial Resistance;antimicrobial resistant infection;Bacteria;Bacterial Infections;bactericide;Biological;biological adaptation to stress;Biology;Ceftriaxone;Cell Culture System;Cell Culture Techniques;cell envelope;cell injury;Cell Membrane Permeability;Cell Physiology;cell type;Cells;cellular targeting;Chemicals;Clinical;Combating Antibiotic Resistant Bacteria;Cytolysis;Data;Disease;efflux pump;fighting;fluidity;Generations;Goals;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Gram-Positive Bacteria;Growth;human pathogen;In Vitro;in vivo;Infection;inhibitor;innate immune mechanisms;Ion Transport;Laboratories;Lipid Bilayers;Macrophage;Maintenance;Mammalian Cell;Membrane;Microbial Biofilms;Modeling;multi-drug resistant pathogen;Mus;mutant;Natural Immunity;novel strategies;pathogen;pathogenic bacteria;Pathway interactions;periplasm;Permeability;Predisposition;prevent;Process;Production;Protons;Protoplasts;Research;Salmonella;Salmonella typhimurium;Signal Transduction;small molecule;Stress Response Signaling;Testing;Tissues;tool;Toxic effect;transcriptome;voltage

PROJECT_TITLE: Infection-Dependent Vulnerabilities of Gram-negative Bacterial Pathogens


ADMINISTERING_IC: LM

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE The goal of Yale's Biomedical Informatics and Data Science training program is to provide pre-doctoral and post-doctoral trainees with coursework and research experiences that will allow them to pursue productive research careers in Biomedical Informatics and Data Science. The depth and strength of our curriculum and research experiences emphasize the development of new knowledge to advance the scientific disciplines of biomedical informatics and data science. Finally, our trainees have demonstrated their abilities to carry out independent research at a high level compatible with publication of results and competition for research grants and contracts. 1

PI_NAMEs: BRANDT, CYNTHIA A. (contact);GERSTEIN, MARK BENDER

PROGRAM_OFFICER_NAME: BINGHAM, CLAYTON SCOTT

PROJECT_TERMS: Applications Grants;Area;Bioinformatics;biomedical data science;biomedical informatics;career;Clinical Informatics;Clinical Research;Collaborations;Computational Biology;computer science;Data Science;Data Set;Doctor of Philosophy;Doctor's Degree;Educational Curriculum;Enrollment;Environment;Evaluation;experience;Faculty;Feedback;Funding;Goals;Health Occupations;Health Sciences;Healthcare;HIV;Informatics;Leadership;Master of Science;Medical center;Medical Informatics;Mentors;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Productivity;programs;Public Health Informatics;Public Health Schools;Publications;Research;Research Project Grants;Schools;Science;skills;success;Supervision;Training;Training Programs;Universities;Update;Work

PROJECT_TITLE: Biomedical Informatics and Data Science Training at Yale


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: HOUSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: The proposed research is relevant to public health because the development of high-density, long-term neural recording tools has the potential to help us understand the fundamental mechanisms of neural circuitry in the spinal cord and explore treatments of neurological conditions. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to the development of new biomedical techniques and devices that will improve the understanding, treatment, and prevention of disease.

PI_NAMEs: LUAN, LAN ;XIE, CHONG  (contact)

PROGRAM_OFFICER_NAME: HWANG, GRACE MEI-HUA

PROJECT_TERMS: Address;Animal Experimentation;Animal Model;Animals;Area;awake;Behavior;Bilateral;Black Box;Brain;Brain region;brain tissue;cell type;Cells;Characteristics;Chronic;Cicatrix;Communities;Computer software;Computers;Data;data streams;density;design;Destinations;Development;Devices;Diameter;digital;Disease;disorder prevention;Electrodes;Electronics;Electrophysiology (science);Esthesia;Etiology;flexibility;Future;Genetic;grasp;implantation;improved;in vivo;Individual;integrated circuit;Laboratories;light weight;Locomotion;Measures;Mechanics;Mediating;meter;miniaturize;Mission;Monitor;Motor Neuron Disease;Movement;Movement Disorders;Mus;nanoelectronics;Nervous System;neural;neural circuit;Neurologic;neuromechanism;Neurons;Neurosciences;new technology;Noise;Operative Surgical Procedures;pilot test;Population;Positioning Attribute;Protocols documentation;Public Health;Rattus;Reflex action;Research;Resolution;response;Rice;Rodent;scale up;Scientist;Sensory;Site;Sorting;Speed;Spinal;Spinal Cord;Spinal cord injury;Spinal Injuries;Stroke;Structure;success;System;Techniques;Technology;Testing;Tissues;tool;United States National Institutes of Health;Urination;Weight;Withdrawal;Work

PROJECT_TITLE: Optimizing ultraflexible electrodes and integrated electronics for high-resolution, large-scale intraspinal recording and modulation


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Pediatric;Rare Diseases

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE – Children’s Hospital Los Angeles Children’s Hospital Los Angeles is excited to be a member of the Collaborative Pediatric Critical Care  Research Network and will bring valuable scientific expertise to the network related to pediatric mechanical  ventilation and respiratory diseases, data science, and informatics. We are fully committed to be an engaged  member of the network and recruit critically ill patients with sepsis into a clinical trial.

PI_NAMEs: KHEMANI, ROBINDER  (contact)

PROGRAM_OFFICER_NAME: JENKINS, TAMMARA L

PROJECT_TERMS: Admission activity;Anesthesiology;Anticoagulation;Beds;Binding Sites;Biological;Biomedical Engineering;California;Cardiac;Cardiopulmonary Bypass;Caring;Child;Childhood;Clinical;clinical center;clinical research site;Clinical Trials;Coagulation Process;Collaborations;Complement;computerized;Consensus;Contracts;County;Critical Care;Critical Illness;Data;Data Coordinating Center;Data Science;design;Development;Emotional;Enrollment;Ensure;Epigenetic Process;ethnic diversity;Ethnic Origin;expectation;Faculty;functional status;Funding;Future;Genetic;Goals;Good Clinical Practice;Health;health related quality of life;Hemorrhage;Hispanic;Immune;immunoregulation;implementation science;Individual;Infant;Informatics;Infrastructure;innovation;interest;International;Knowledge;Leadership;Los Angeles;Lung;Mechanical ventilation;Medicine;meetings;member;Mentors;Mentorship;Methods;Monitor;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;multidisciplinary;National Heart, Lung, and Blood Institute;Neonatology;Neurocognitive;Observational Study;Oranges;participant enrollment;Patients;Pediatric Acute Lung Injury;Pediatric Acute Respiratory Distress Syndrome;Pediatric Hospitals;Pediatric Intensive Care Units;Performance;Phenotype;Positioning Attribute;Practice Guidelines;Procedures;Productivity;Protocols documentation;pulmonary function;Pulmonology;Qualifying;Race;racial diversity;recruit;Research;Research Personnel;Research Training;respiratory;Respiratory Diaphragm;Respiratory Disease;Running;Sampling;Scientist;Sepsis;Site;socioeconomic diversity;Socioeconomic Factors;success;support tools;symposium;Talents;translational scientist;treatment and outcome;United States National Institutes of Health;ventilation;Ventilator;virtual;Work

PROJECT_TITLE: Collaborative Pediatric Critical Care Research Network - Clinical Site


ADMINISTERING_IC: GM

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Endocrine Disruptors;Pediatric

ORG_CITY: CHAPEL HILL

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Iterative Design to Engage All Learners PROJECT NARRATIVE  Using cutting-edge, interdisciplinary research on per- and polyfluoroalkyl substances (PFAS) as a foundation, the Center for Public Engagement with Science in the UNC Institute for the Environment, proposes Iterative Design to Engage All (IDEA) Learners, with a goal of building the capacity of NC teachers, especially those in economically disadvantaged communities, to introduce current biomedical science and career opportunities to their students. Through professional development grounded in design thinking and active collaboration with PFAS researchers, teachers will increase their content knowledge while also improving their pedagogy. As a result, they will be positioned to promote the STEM opportunities that await students in the rapidly evolving biomedical research landscape, ultimately cultivating a more diverse biomedical workforce.

PI_NAMEs: GRAY, KATHLEEN M (contact);HAINE, DANA

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: academic preparation;Address;Air;Animals;Area;Biomedical Research;Blood;career;Chemicals;Cities;Clothing;Collaborations;college;Community of Practice;consumer product;County;COVID-19 susceptibility;Data;design;Development;drinking water;economic disparity;Ecosystem;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Engineering;Environment;Environmental Health;Ethnic Population;Feedback;Female;Fostering;Foundations;Fright;Future;Gills;Goals;Health;High School Student;Human;Immune system;improved;Individual;Instruction;Interdisciplinary Study;interest;iterative design;Jordan;Knowledge;learning materials;Limited English Proficiency;manufacturing facility;Modeling;neighborhood disadvantage;North Carolina;Occupations;pedagogy;peer coaching;Persons;Poly-fluoroalkyl substances;Positioning Attribute;prototype;public engagement with science;Public Health;racial population;Recreation;Research;Research Personnel;Schools;Science;science education;science teacher;Scientist;Self Efficacy;Series;Source;Students;summer institute;System;Systems Biology;teacher;Thinking;Underrepresented Minority;Underrepresented Populations;Universities;Water;Water Supply

PROJECT_TITLE: Iterative Design to Engage All (IDEA) Learners: A teacher-scientist collaboration to feature biomedical research and engage diverse high school students

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Pediatric;Prevention;Sepsis

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE – University of Pittsburgh Medical Center Review of 109 million death records from the Global Burden of Disease study (1991-2017) found that one in  five people in the world die from sepsis caused by overwhelming infection, with the majority of these being  children. The new Eunice Kennedy Shriver NICHD Collaborative Pediatric Critical Research Network  comprised of 12 primary sites and 12 ancillary sites proposes to perform a placebo controlled randomized trial  to test the hypothesis that personalized utilization of molecular biology revolution breakthrough diagnostics and  recombinant therapies to improve a child’s ability to fight infection and control inflammation will reduce this  public health burden.

PI_NAMEs: CARCILLO, JOSEPH A (contact)

PROJECT_TERMS: Accounting;Acute Renal Failure with Renal Papillary Necrosis;Admission activity;anakinra;Anti-Inflammatory Agents;Biological Markers;Blinded;Blood;Brain Injuries;burden of illness;Cessation of life;Child;Child Development;Child Health;Childhood;Cities;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Contracts;Critical Care;Critical Illness;Critically ill children;Data;Data Coordinating Center;Death Records;design;Development;Diagnostic;Double-Blind Method;Enhancers;Enrollment;expectation;experience;Faculty;feasibility trial;fighting;fitness;Functional disorder;Funding;Futility;Future;Genetic;Genetic study;Goals;Good Clinical Practice;Heart Arrest;Immune;Immunologic Monitoring;immunoregulation;improved;Individual;Infant;Infection;Inflammation;innovation;Interleukin-6;Kansas;Kidney;Laboratories;Liquid substance;Manuscripts;Masks;Medical center;meetings;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Molecular Biology;Monoclonal Antibodies;Morbidity - disease rate;mortality;Multiple Organ Failure;National Institute of Diabetes and Digestive and Kidney Diseases;National Institute of General Medical Sciences;National Institute of Neurological Disorders and Stroke;next generation;Nurses;Organ;Outcome;Parental Consent;participant enrollment;pathogen;Patients;Pediatric Hospitals;pediatric sepsis;Peer Review;Performance;Persons;Phenotype;Placebos;Population;Positioning Attribute;Principal Investigator;Procedures;Productivity;Protocols documentation;Public Health;Publishing;Randomized;randomized placebo controlled trial;Recombinant Granulocyte-Macrophage Colony-Stimulating Factors;Recombinant Interleukin-1;Recombinants;Research;Research Personnel;Research Training;Resuscitation;Role;Scientist;Sedation procedure;Sepsis;Site;Study Section;success;Syringes;Talents;Technology;Testing;treatment as usual;trial planning;Universities;Work


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Precision Medicine;Rehabilitation;Stroke

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Stroke is a devastating disease that progresses rapidly and irreversibly and requires important decisions to be made quickly in the context of both imaging and non-imaging clinical data. We will apply deep learning artificial intelli- gence methods to integrate these disparate streams of data to predict short- term tissue and long-term clinical outcome under the conditions of successful and unsuccessful reperfusion and perform studies to understand the general- izability and explainability of the AI methods. This will enable us to personalize triage pathways, reduce the time and cost spent imaging without losing valuable information, and better understand the underlying rationale of these predictions.

PI_NAMEs: ZAHARCHUK, GREGORY GEORGE (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Acute;acute stroke;Algorithms;Artificial Intelligence;artificial intelligence method;Attention;Caring;Cerebral Infarction;Cerebrovascular Disorders;Cessation of life;Clinical;Clinical Data;clinical practice;Clinical Trials;cohort;Collaborations;Computer software;convolutional neural network;cost;Data;data streams;Decision Making;deep learning;deep learning model;deep neural network;Disabling;Disease;Disparate;endovascular thrombectomy;Etiology;experience;explainable artificial intelligence;follow-up;Functional disorder;functional outcomes;functional status;Goals;Hemorrhage;Image;imaging study;improved;Individual;Infarction;Intervention;Ischemia;Ischemic Stroke;Lead;Learning;Location;Magnetic Resonance Imaging;Maps;Medical;Medicine;Methods;Minor;Modeling;neural network;neuroimaging;Outcome;outcome prediction;Pathway interactions;patient population;Patient Selection;Patients;Performance;Perfusion;perfusion imaging;Population;predictive modeling;Process;Prospective cohort;Protocols documentation;randomized, clinical trials;Reperfusion Therapy;Research Personnel;Risk;Safety;Site;Speed;Stroke;stroke patient;stroke trials;Techniques;Testing;Thrombectomy;Time;Tissues;tool;Training;transfer learning;treatment effect;Triage;Work;X-Ray Computed Tomography

PROJECT_TITLE: Predicting Tissue and Functional Outcome in Acute Stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Recovery Support Services;Substance Misuse

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative Mindfulness treatment for substance use disorder is a particularly efficacious aftercare approach for preventing relapse to substance use among stabilized patients stepping down from more intensive treatment. However, implementation strategies are inadequate and there are no technology-based aftercare mindfulness treatments for preventing relapse substance use. This career development award proposal involves training and research in developing and evaluating the first web-based aftercare mindfulness treatment for preventing relapse to substance use.

PI_NAMEs: ROOS, COREY  (contact)

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: addiction;Adherence;Affect;Affective;Aftercare;Alcohol consumption;Award;Awareness;career;Cellular Phone;Client;Clinic;Clinical Trials;craving;Data;design;Drug Screening;Ecological momentary assessment;evidence base;Exercise;Feedback;follow-up;Goals;hands on research;Home;illicit drug use;implementation strategy;Individual;Internet;K-Series Research Career Programs;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methods;mindfulness;Mindfulness Training;multilevel analysis;negative affect;Online Systems;Outpatients;Participant;patient oriented;patient oriented research;Patient Self-Report;Patients;Persons;Phase;pilot trial;Positioning Attribute;primary outcome;Privatization;Process;programs;prototype;Randomized;Randomized, Controlled Trials;Recovery;Relapse;relapse prevention;Research;Research Activity;Research Personnel;Research Project Grants;Resolution;satisfaction;secondary outcome;Stress;substance use;Substance Use Disorder;substance use treatment;Surveys;symposium;Technology;Testing;theories;therapy development;Time;Training;training opportunity;treatment adherence;treatment as usual;treatment duration;Urine;usability;user centered design;web app;Work

PROJECT_TITLE: Web-Based Mindfulness Treatment to Prevent Relapse to Substance Use


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: KNOXVILLE

ORG_NAME: UNIVERSITY OF TENNESSEE KNOXVILLE

ORG_STATE: TN

PHR: Project Narrative The success of an antibiotic is dependent on it's ability to bind to and move through the cell membrane of its bacterial target. Our research program applies new technologies that allow us to “watch” native antibiotics interact with living bacterial cells and study the factors that inﬂuence their activity. This new insight can provide crucial information for designing drugs to combat antibiotic resistance.

PI_NAMEs: CALHOUN, TESSA RAE (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: Address;Adsorption;Antibiotic Resistance;Antibiotics;Bacteria;Behavior;Binding;Biological Models;Cell membrane;Cell Wall;Cells;combat;Dependence;Drug Design;experimental study;Generations;Goals;improved;Individual;insight;Maps;Mediating;Membrane;Methodology;Microbial Biofilms;Microscopy;Movement;new technology;programs;Research;Role;second harmonic;small molecule;Spectrum Analysis;success;Techniques;Tetracyclines;uptake

PROJECT_TITLE: Probing How Living Bacterial Membranes Control Small Molecule Uptake

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-U(55)R]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: IOWA CITY

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Fibrosis and scarring from injury and disease costs $20 billion annually to treat in the US, and even when treated remains a persistent problem that significantly impacts quality of life. The objective of this proposal is to determine how human adipocyte lineage cells impact wound healing, with a specific emphasis on fibroblast interactions. Successful completion of this proposal will substantially improve our understanding of adipose- fibroblast interactions that ultimately could be used to develop more effective therapies for wound healing and fibrosis.

PI_NAMEs: ANKRUM, JAMES ALLEN;SANDER, EDWARD A (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: 3-Dimensional;Adipocytes;adipokines;adipose derived stem cell;Adipose tissue;Appearance;Attention;Autologous;Back;Behavior;Biological Assay;Blood Vessels;Cell Lineage;cell type;Cells;Cicatrix;Clinical;Communication;Complement;Complex;Cost of Illness;Coupled;Data;Dermal;design;Development;effective therapy;Engineering;Extracellular Matrix;Extracellular Matrix Proteins;Family suidae;fat grafting;Fatty acid glycerol esters;Fibroblasts;Fibrosis;Fractionation;Genetic Transcription;Genomics;Goals;healing;Human;improved;In Vitro;in vitro Model;Injury;innovation;interest;knowledge base;mechanical properties;Mechanics;Myofibroblast;novel;novel therapeutic intervention;Operative Surgical Procedures;Phenotype;prevent;Prevention;Process;Production;Proteomics;Quality of life;Reconstructive Surgical Procedures;response;Role;Site;Source;spheroids;stem cells;subcutaneous;Surgeon;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;Tissues;Transplantation;Work;wound bed;wound healing;Wound healing therapy;Wound models

PROJECT_TITLE: Controlling Adipocyte-Myofibroblast Interactions to Improve Healing

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Health Services;Hematology;Infectious Diseases;Pediatric;Sepsis

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: PROJECT NARRATIVE – Children’s Hospital of Philadelphia This proposal is relevant to public health because Children’s Hospital of Philadelphia (CHOP) as a clinical  site will bring a racially, ethnically, and socioeconomically diverse population of critically ill children as  research participants to the CPCCRN. This diverse population will allow personalized treatment of sepsis induced MODS to be fully investigated. CHOP as a clinical site will contribute to the NICHD’s mission that all  children have the opportunity to fulfill their potential to live healthy and productive lives free from disease or  disability.

PI_NAMEs: BERG, ROBERT ALLEN (contact);FITZGERALD, JULIE C. HOLLOWS

PROJECT_TERMS: Address;Agreement;anakinra;antagonist;Anti-Inflammatory Agents;Award;Beds;Blocking Antibodies;Budgets;career development;Caring;Child;Childhood;Clinical and Translational Science Awards;clinical center;Clinical Research;clinical research site;Clinical Sciences;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Collection;Companions;Contracts;Country;Critical Care;Critical Illness;Critically ill children;Data;Data Collection;Data Coordinating Center;Dedications;Development;disability;Discipline of Nursing;Disease;Dose;electronic data;Eligibility Determination;Ethnic Origin;expectation;experience;Faculty;Family;Feedback;Functional disorder;Funding;Good Clinical Practice;Granulocyte-Macrophage Colony-Stimulating Factor;health related quality of life;Home;Human;Immune;immune function;Immune Targeting;Immunophenotyping;immunoregulation;immunosuppressed;Immunosuppression;Individual;Infant;innovation;Institution;Institutional Review Boards;Interleukin 6 Receptor;Interleukin-1 Receptors;International;Intervention;Journals;Leadership;Medical;Medicine;meetings;Mentors;Mentorship;Methods;Mission;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multiple Organ Failure;National Heart, Lung, and Blood Institute;National Institute of Child Health and Human Development;Network Infrastructure;news;next generation;Observational Study;Operative Surgical Procedures;Organ;Outcome;Participant;participant enrollment;patient population;Patients;pediatric department;Pediatric Hospitals;Pediatric Research;Performance;personalized medicine;Persons;phenomics;Phenotype;Philadelphia;Physician Executives;Population;Population Heterogeneity;Procedures;Productivity;professor;programs;Protocols documentation;Public Health;Publications;Race;racial diversity;Recombinants;Reporting;Research;Research Personnel;Research Training;Risk Factors;Role;sample collection;Sampling;Science;Scientist;Sepsis;septic;Site;socioeconomics;square foot;success;Syndrome;System;Talents;tertiary care;Time;tocilizumab;Training;Translational Research;United States National Institutes of Health


ADMINISTERING_IC: CA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: LAMASSU BIO INC

PHR: Project narrative Sarcomas account for 13,000 new diagnoses per year in the United States. They are treated with major surgery, toxic chemotherapy, and/or radiation, but many fail therapy. More effective and less toxic therapies are needed. We propose development of a new drug that activates an intrinsic defense mechanism (p53). The target of our novel therapy is MDM2, which inactivates p53, thereby increasing treatment resistance. Other cancers have a similar mechanism for p53 inactivation thus, an effective new drug for relatively rare sarcomas may impact treatment paradigms for many other cancers as well.

PI_NAMEs: HANNA, GABI  (contact)

PROGRAM_OFFICER_NAME: BOZZA, WILLIAM PATRICK

PROJECT_TERMS: Abdomen;Adjuvant Therapy;Advanced Development;Apoptosis;Area Under Curve;arm;Biological Availability;burden of illness;cancer therapy;cancer type;Cell Death;cell growth;Chemotherapy and/or radiation;Clinic;Clinical;clinical development;Clinical Trials;cohort;Collaborations;Data;Defense Mechanisms;Desmoplastic Small Round Cell Tumor;Development;Dose;Drug Kinetics;drug metabolism;early phase trial;efficacy study;experience;first-in-human;Foundations;Funding;Future;Goals;Growth;Half-Life;High Prevalence;Human;in vivo;inhibitor;innovation;Light;liposarcoma;Malignant Neoplasms;manufacture;MDM2 gene;Modeling;Molecular;Monkeys;morphogens;Mutate;neoplastic cell;Newly Diagnosed;Normal tissue morphology;novel;novel therapeutics;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;phase I trial;Positioning Attribute;Pre-Clinical Model;prevent;Primary Neoplasm;programs;Proteins;rare cancer;Rattus;Recommendation;Recurrence;Refractory;Safety;Sarcoma;screening;Small Business Innovation Research Grant;small molecule;Soft tissue sarcoma;Solid Neoplasm;Testing;Therapeutic;therapy resistant;Thrombocytopenia;Toxic effect;Toxicology;TP53 gene;Treatment Protocols;tumor;tumor growth;tumor initiation;Tumor Suppressor Proteins;United States;Work

PROJECT_TITLE: Development of a novel small molecule MDM2 inhibitor for innovative sarcoma treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CTH-T(10)B]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence;Neurosciences

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PI_NAMEs: BUONOMANO, DEAN V;MASMANIDIS, SOTIRIS  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Animals;Area;Automobile Driving;Behavior;Behavioral;Brain;Cerebellar Nuclei;Code;Computer Models;Corpus striatum structure;Cues;Data;data modeling;Electrophysiology (science);entorhinal cortex;Event;experimental study;flexibility;Food;Generations;Goals;Hippocampus;Huntington Disease;Impairment;innovation;insight;Instruction;Interneurons;learned behavior;Learning;Life;Link;Medial;Modeling;Motor;Motor Cortex;Movement;Mus;Nervous System Disorder;neural;Neural Network Simulation;neural patterning;Neurosciences;optogenetics;Parkinson Disease;Parvalbumins;Pattern;Phase;Play;Prefrontal Cortex;Property;Reading;Recovery;Recurrence;recurrent neural network;response;Rewards;Role;Shapes;Signal Transduction;Speed;Surveys;System;Testing;Time;time interval;transmission process;Work

PROJECT_TITLE: CRCNS: Multiple clocks for the encoding of time in corticostriatal circuits


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Understanding how neurons are correctly assembled into functional circuits will provide critical insight into developmental disorders of the nervous system and may inform strategies to promote neuronal repair in cases of injury or disease. Our research in this proposal will investigate how intracellular trafficking of axon guidance receptors leads to the precise spatial and temporal control of their activity during development of the mammalian spinal cord and brain. These studies are likely to inform the study of development in many tissue types in addition to the nervous system, since axon guidance signaling molecules are known to play diverse roles during tissue morphogenesis.

PI_NAMEs: BASHAW, GREG J. (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Adaptor Signaling Protein;Animals;Antibodies;Axon;axon guidance;axon regeneration;Bilateral;Binding;Biochemical;Biological;Biological Assay;Brain;Cell Line;Cells;Central Nervous System;conditional knockout;conditional mutant;Cues;Data;Defect;Development;developmental disease;Disease;Dissociation;Dorsal;Drosophila genus;Drosophila sli protein;Dyes;Elements;Embryo;Endosomes;Exhibits;experimental study;extracellular;Family;Floor;fly;gene function;Genetic;Growth Cones;hindbrain;Human;Immunofluorescence Immunologic;In Situ;In Vitro;in vivo;Injury;insight;late endosome;Ligands;Ligase;Link;lipophilicity;Malignant Neoplasms;Mammals;Mediating;Messenger RNA;Molecular;Monitor;Morphogenesis;motor behavior;mouse genetics;Mus;mutant;Nerve Regeneration;Nervous System;nervous system development;Nervous System Disorder;neural circuit;Neurons;novel;Pathway interactions;Pattern;Play;premature;prevent;Process;protein expression;protein transport;Proteins;Proteomics;receptor;Receptor Signaling;recruit;Regulation;repaired;Reporter;Research;response;Role;screening;Signal Pathway;Signal Transduction;Signaling Molecule;Spinal;Spinal Cord;Stains;Surface;Synapses;System;Techniques;Testing;Therapeutic;Tissues;trafficking;Transcriptional Regulation;ubiquitin-protein ligase;Vertebrates;Work

PROJECT_TITLE: Regulation of axon guidance receptor trafficking in the developing mammalian central nervous system

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Networking and Information Technology R&D (NITRD);Patient Safety;Pneumonia and Influenza;Precision Medicine;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

PHR: PROJECT NARRATIVE Many older adults are at risk of illness, hospitalization, and death from vaccine-preventable diseases. Moreover, there are significant racial and ethnic disparities in care with even lower vaccination rates among African Americans, Hispanics, and Asians. In this study, we will use analytical methods to identify high-risk subgroups, test personalized nudges to address barriers among these groups, and then implement a pragmatic, multisite trial to evaluate the effectiveness of personalized nudges to clinicians and patients to improve vaccination rates among older adults and reduce disparities in care.

PI_NAMEs: LIAO, JOSHUA M;MEHTA, SHIVAN JATIN (contact);NAVATHE, AMOL S

PROGRAM_OFFICER_NAME: KIM, THERESA YOUNGJOO

PROJECT_TERMS: Address;Adopted;African American population;analytical method;Asian population;Behavior;Behavioral;behavioral economics;Categories;Cessation of life;Characteristics;Clinical;Cluster randomized trial;Data;Decision Making;design;Disease;disparity reduction;effectiveness evaluation;Effectiveness of Interventions;Electronic Health Record;Environment;Environmental Risk Factor;ethnic disparity;ethnic minority population;Ethnic Origin;Foundations;Future;health care disparity;health service use;Health system;Healthcare;Herpes zoster disease;Heterogeneity;high risk;high risk population;Hispanic Populations;Hospitalization;Immune;improved;Influenza;Influenza vaccination;Intervention;Lead;Machine Learning;Medical;Medical center;Medicine;Methods;Modeling;multi-site trial;multidisciplinary;older adult;operation;Patient-Focused Outcomes;Patients;Pattern;peer;Pennsylvania;personalized approach;Phase;pilot test;Pneumococcal Infections;pragmatic trial;Predictive Factor;prescription opioid;Preventive care;Preventive Health Services;primary care clinician;Primary Care Physician;primary care practice;Public Health;Public Health Informatics;Race;racial disparity;racial minority population;Randomized;Resistance;response;Risk;Screening for cancer;Site;Socioeconomic Factors;statistics;Subgroup;technology platform;Testing;therapy design;treatment effect;United States;United States Department of Veterans Affairs;Universities;unvaccinated;Vaccination;Vaccines;Vendor;Veterans Health Administration;Visit;Washington;Work;Workload

PROJECT_TITLE: BE IMMUNE: Behavioral Economics to Improve and Motivate vaccination Using Nudges through the EHR


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Pediatric;Prevention;Rural Health

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE The mechanisms by which some health-associated microbes cause inflammation in the gut are poorly- understood, unlike the case with disease-causing microbes. This study seeks to identify these mechanisms in a cohort of children from rural Bangladesh at risk of undernutrition. This research will shed light on biological pathways to target for future precision engineering of the gut microbiota to mitigate childhood stunting.

PI_NAMEs: GREMBI, JESSICA A. (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: 3 year old;Address;Age;Alternative Therapies;Antibiotics;Antimicrobial Resistance;Bangladesh;Bifidobacterium;Bioinformatics;Biological;Blood;Blood specimen;Carbohydrates;career;Characteristics;Child;Child Health;Childhood;Clinical;Clinical Trials;cohort;commensal microbes;Competence;Diet;dietary supplements;Disease;Endotoxins;Engineering;enteric pathogen;Environmental Risk Factor;Etiology;experience;Feces;Fellowship;Food;Foundations;Future;Gastroenterology;Genes;Genome;Genomics;Goals;Growth;gut inflammation;gut microbes;gut microbiome;gut microbiota;Health;Human;Human Biology;Human Microbiome;Immune response;Impairment;improved;in vivo;Inflammation;Inflammatory;Inflammatory Response;insight;Intervention;Intestinal permeability;Intestines;Life;Lipids;Malnutrition;Measurement;Mediating;Mentorship;Metabolic;metabolomics;metagenomic sequencing;Metagenomics;Microbe;microbial;microbiota;Modeling;mouse model;Mucosal Immune System;Multiomic Data;Mus;novel;nutrient absorption;nutritional supplementation;Outcome;Pathway interactions;Periodicals;Permeability;Physiological;postnatal;Production;programs;rational design;reconstitution;Research;Research Personnel;resistance gene;Risk;Role;rRNA Genes;Rural;Sampling;Sanitation;Site;skills;small molecule;Specimen;Statistical Models;statistics;stem;stool sample;systemic inflammatory response;Taxonomy;Training;Transplantation;Variant;Work

PROJECT_TITLE: Towards a mechanistic understanding of the role of gut microbiota in postnatal growth impairment


ED_INST_TYPE: SCHOOLS OF SOCIAL WELFARE/WORK

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care

PHR: Project Narrative This project will compare two training models of an evidence-based online dementia care training program for direct care staff in assisted living. It will examine the extent to which each model is implemented and achieves its intended outcomes to improve staff knowledge and attitudes, change care practices, and improve the well- being of staff, residents, and residents' family members. Results will inform next steps in dementia care training for the assisted living and broader long-term care workforce.

PI_NAMEs: ZIMMERMAN, SHERYL  (contact)

PROJECT_TERMS: Adoption;Age Years;Alzheimer's Disease;Alzheimer's disease related dementia;Area;arm;Assisted Living Facilities;Attitude;Beds;Behavior;behavior change;burnout;care outcomes;care providers;Caring;Case Mixes;Certification;Characteristics;Cluster randomized trial;Communities;Community Healthcare;community living;Community Participation;Competence;Computers;cost;Country;Data;Dementia;dementia care;Development;Discipline of Nursing;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;evidence base;expectation;experience;Family;Family member;Feeling;handheld mobile device;high school;Hour;Impaired cognition;improved;improved outcome;Individual;Injury;Intention;interest;Knowledge;Learning;Licensing;Long-Term Care;Minority;Modeling;National Institute on Aging;Occupations;Outcome;peer support;Perception;person centered;Personal Satisfaction;Persons;Preparation;Procedures;programs;Provider;Psychological reinforcement;Quality of life;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reaction;recruit;Reporting;residential care facility;Residential Treatment;response;Self Care;Severities;skills;skills training;Tablet Computer;Testing;Training;Training Programs;virtual;Waiting Lists;Workplace

PROJECT_TITLE: Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-B(90)S]


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Aberrant protein aggregation is associated with many age-related diseases, such as Alzheimer’s disease and cancer. In this project, we focus on age-dependent aggregation of RNA-binding proteins (RBPs), which play key roles in a wide variety of cellular functions and are implicated in a growing number of diseases. We will combine innovative imaging technologies with powerful genomic and proteomic tools to perform a systems-level analysis of RBP aggregation and its functional consequences on cell physiology and lifespan, laying the foundation for the development of therapeutic and preventive strategies towards age-associated diseases.

PI_NAMEs: HAO, NAN  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Affect;age related;age related changes;age-related disease;Aging;aging process;aging related;Alzheimer's Disease;Binding Proteins;Biochemical;Biological Models;Biophysics;Cell Aging;Cell Physiology;Cells;cellular imaging;Communities;Complement;Complex;Controlled Environment;Data;data integration;data sharing;Deacetylase;Dedications;design;Disease;experimental study;Foundations;functional decline;Gene Expression;Gene Expression Regulation;Genes;Genomics;Imaging technology;Individual;innovation;insight;Libraries;life span;Light;Link;Liquid substance;Lysine;Malignant Neoplasms;Measurement;Mediating;Messenger RNA;Methods;Microfluidic Microchips;microfluidic technology;Microfluidics;Microscopy;mutant;Neurodegenerative Disorders;overexpression;Pathologic;Pathway interactions;Phase;Phase Transition;Phenotype;Play;population based;Post-Transcriptional Regulation;Prevention strategy;prion-like;Process;Property;protein aggregation;Proteins;Proteome;Proteomics;proteostasis loss;response;Ribonucleoproteins;RNA analysis;RNA metabolism;RNA-Binding Proteins;Role;Saccharomyces cerevisiae;screening;sensor;Solid;Structure;System;Systems Biology;Technology;Testing;therapeutic development;tool;transcriptome;web site;Yeasts

PROJECT_TITLE: Systems biology analysis of RNA-binding protein aggregation during cellular aging

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

PHR: Project Narrative Atherosclerotic vascular disease remains the leading cause of death in the United States with the majority of mortality due to coronary artery disease and myocardial infarction. Macrophages are primary cells that specialize in removing the excess lipids and other debris present in the atherosclerotic plaque. We have found that macrophages have the ability to augment their degradation machinery and when this response is stimulated genetically in mice, they have reduced atherosclerosis. We have also learned of a parallel degradation mechanism best described in simple organisms that can potentially be leveraged to clear excess debris in macrophages. Thus, we propose to evaluate the various mechanisms of stimulating the macrophage degradation machinery both in vitro and in vivo with the goal of developing a completely novel strategy of treating atherosclerosis.

PI_NAMEs: RAZANI, BABAK  (contact)

PROGRAM_OFFICER_NAME: CHEN, JUE

PROJECT_TERMS: Apoptotic;Area;Arterial Fatty Streak;atherogenesis;atheroprotective;Atherosclerosis;Autophagocytosis;Biogenesis;Body Composition;Body Weight decreased;Cardiovascular Diseases;Cause of Death;Cell Death;Cell Physiology;Cells;Clinical;Complex;Coronary Arteriosclerosis;Cytoplasm;cytotoxic;cytotoxicity;Data;Deposition;Disease;Esterification;Evaluation;Event;Excision;experience;Fibroblasts;Foam Cells;Functional disorder;Future;gene network;Genes;Goals;Heart failure;Hydrolysis;Hyperactivity;Hyperlipidemia;Hypertension;In Vitro;in vivo;Inclusion Bodies;Infiltration;Inflammasome;Inflammatory;insight;interest;Investigation;Learning;lipid metabolism;Lipids;Lipoproteins;Lysosomal Storage Diseases;Lysosomes;Macrophage;Mediating;Membrane;Methods;Mitochondria;Modification;Molecular Chaperones;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Myocardial Infarction;Neurodegenerative Disorders;novel;novel strategies;novel therapeutic intervention;Organelles;Organism;overexpression;oxidized low density lipoprotein;Pathogenicity;Pathway interactions;Phagocytosis;Phenotype;Prevention strategy;Process;protein aggregation;Proteins;Proteomics;response;Risk Factors;Role;Series;Signal Transduction;Stimulus;Stroke;System;Testing;Therapeutic;transcription factor;Transgenic Mice;Tropism;United States;uptake;Variant;Work

PROJECT_TITLE: Clearance of macrophage p62-enriched protein aggregates as a therapy for atherosclerosis

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Eye Disease and Disorders of Vision

ORG_CITY: ROCHESTER

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Thyroid Eye Disease (TED) is an autoimmune disease that causes the tissue behind the eye to expand leading to eye protrusion, double vision, pain and sometimes blindness. Unfortunately, there is no cure and few specific therapies to treat TED. The goal of this project is to understand the molecular pathways by which cells called fibroblasts cause tissue expansion and pathology in TED.

PI_NAMEs: WOELLER, COLLYNN FREMONT (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Adipocytes;Adrenal Cortex Hormones;Antigens;Aromatic Hydrocarbons;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Attenuated;Autoantibodies;Autoimmune Diseases;Automobile Driving;Binding;Blindness;Blocking Antibodies;Cell Fate Control;cell growth;Cell Proliferation;Cells;Cicatrix;cigarette smoke;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen;Culture Techniques;cytokine;Data;Development;Diplopia;Disease;Equilibrium;Event;experimental study;exposure to cigarette smoke;Extracellular Matrix;Eye;Eye diseases;Fibroblasts;Functional disorder;Genes;Genetic Transcription;Goals;Graves' Disease;HIF1A gene;Hormone Receptor;Hyaluronan;hypoxia inducible factor 1;IGF1 gene;Immune system;In Vitro;in vivo;Individual;Inflammatory;Insulin-Like-Growth Factor I Receptor;Knowledge;Ligands;Lipids;Mediating;Mediator;Modeling;modifiable risk;Molecular;mutant;Myofibroblast;novel;Ocular orbit;Operative Surgical Procedures;Optic Nerve;Orbital Diseases;Pain;Pathologic;Pathology;Pathway interactions;Patients;Plasma;Positioning Attribute;Production;Proliferating;Proteomics;Radiation therapy;receptor;receptor expression;Receptor Signaling;Regulation;Risk Factors;Role;Signal Induction;Signal Transduction;Signs and Symptoms;Small Interfering RNA;Smoke;Smoking;Swelling;Symptoms;Technology;Testing;Therapeutic;therapeutic target;three dimensional cell culture;thyroid associated ophthalmopathies;Thyroid Gland;Thyrotropin Receptor;Time;Tissue Expansion;Tissues;transcription factor;transcriptome sequencing;Visual impairment;Work

PROJECT_TITLE: Molecular regulation of fibroblast activation in Thyroid Eye Disease


NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Public Health Narrative To treat neurological disorders, we need to have a comprehensive understanding of the brain’s circuits and functionality, and develop systematic techniques of modulating its networks, which would require stable, large-scale chronic neural interfaces with high spatial and temporal precision for long-term recording and manipulation of neural activity. Here we propose to develop and test in non-human primates (NHPs) a stable, large-scale and high-density interface for neural recording and stimulation which enables cell-type specific manipulation of large circuits as well as large-scale network investigation to monitor the changes in the underlying neural networks. Developing such interfaces in NHPs that are evolutionarily close to humans has a great potential to advance our understanding of brain circuits, to provide significant insight for translating this technology to humans, and to be a revolutionary tool for the development of stimulation-based therapies for neurological disorders such as stroke.

PI_NAMEs: CHAMANZAR, MAYSAMREZA  (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Address;Adhesions;Advanced Development;Animal Model;Animals;Area;awake;Behavior;Behavioral;biocompatible polymer;biomaterial compatibility;Brain;Calcium;cell type;Cephalic;Chronic;Communication;Complex;Coupled;density;Deposition;design;Development;Device or Instrument Development;Dura Mater;Electrocorticogram;Electrodes;Electronics;Electrophysiology (science);Engineering;Equilibrium;experimental study;fabrication;Fiber;flexibility;Future;Head;Human;Hybrids;Image;imaging modality;Implant;improved;indium tin oxide;insight;interest;Investigation;Light;light emission;lithography;Macaca;Mechanics;Microfabrication;millisecond;Modeling;Monitor;Monkeys;Morphologic artifacts;multi-photon;multimodal data;Mus;Nervous System Disorder;neural;neural circuit;neural network;Neuronal Plasticity;Neurons;neurophysiology;nonhuman primate;novel;novel therapeutic intervention;Opsin;Optical Coherence Tomography;optical fiber;Optics;optogenetics;parylene C;Pattern;Performance;polydimethylsiloxane;pressure;prevent;Process;Public Health;Publishing;Reporting;Resolution;Site;Source;Stroke;stroke recovery;Structure;success;Surface;System;Techniques;Technology;temporal measurement;Testing;Time;tool;tool development;Translating;Virus

PROJECT_TITLE: Smart Dura: A Functional Large-scale, High-Density Optoelectric Dura for Non-Human Primates

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Contraception/Reproduction;Genetics;Infertility;Urologic Diseases;Women's Health Research

ORG_DEPT: PHARMACOLOGY

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Transposons are pieces for DNA that move to new locations in the genome and can rewrite an organism’s genetic code, but their activity in the germline can also contribute to sterility. The mechanism of how these elements can complete their life cycle in germline cells is incomplete. The experiments outlined in this proposal will define the host factors used for transposition and the window of time when transposons generate new insertions.

PI_NAMEs: TRACY, LAUREN ANN (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Binding Sites;cell type;Cells;Circular DNA;Code;Complementary DNA;cost;Development;Disease;DNA;DNA Ligases;DNA Repair Pathway;DNA Transposable Elements;DNA-Directed DNA Polymerase;Drosophila genus;Drosophila melanogaster;egg;Elements;Event;experimental study;Factor VIII;Female;fly;Future Generations;gene regulatory network;Genes;Genetic Code;Genome;Germ Cells;Germ Lines;Hemophilia A;Human Genome;improved;Infertility;Integration Host Factors;Knowledge;Length;Life Cycle Stages;Location;male;member;Modeling;Monitor;Mutation;nanopore;Nomads;Oocytes;Oogenesis;Organism;Pathway interactions;piRNA;Placentation;preference;Process;Production;recruit;Regulatory Element;Reporter;Repression;Retrotransposon;RNA;RNA Interference;RNA-Directed DNA Polymerase;Single-Stranded DNA;Small RNA;sperm cell;Sperm Maturation;Spermatocytes;Spermatogenesis;Sterility;Study models;syncytin;Technology;Testing;Testis;Time;transcription factor;Writing;XRCC1 gene;Y Chromosome

PROJECT_TITLE: Transposable element mobilization during spermatogenesis in Drosophila

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F06-L(20)L]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE We will investigate how cells of the model biofilm-forming bacterium Vibrio cholerae (the causative agent of the disease cholera) enact coherent population-level behaviors despite cell-to-cell variation in gene expression, aka “noise”. A particular focus will be on how cells collectively integrate multiple sensory inputs to decide whether and when to disassemble a biofilm to disperse and colonize new territories. We expect the results of our studies of this tractable model system will reveal general principles about the emergence of precise collective outcomes from noisy individual cells.

PI_NAMEs: WINGREEN, NED S (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Adhesions;Antibiotic Resistance;antibiotic tolerance;Architecture;Bacteria;bacterial community;Behavior;Biological Models;biophysical model;Bioremediations;cell behavior;Cell Communication;cell community;Cell Density;Cell model;Cell Survival;Cells;cellular imaging;Cellular Structures;Cellularity;Cholera;chronic infection;Collaborations;Color;Communities;Companions;Consumption;Data;Decision Making;Development;Devices;Diffusion;Disease;disease transmission;empowerment;Endemic Diseases;Environment;Enzymes;experimental study;Extracellular Matrix;Filtration;Gene Expression;Gene Expression Profiling;Growth;Habitats;Human;Image;Imaging Techniques;Imaging technology;Individual;individual response;Industrialization;Industry;innovation;insight;Investigation;Laboratories;Laws;Learning;Ligands;Light;Location;Measures;Mechanics;Medical;Medicine;Metabolic;Microbial Biofilms;microbiome;Microscopy;Modeling;Motility;Motion;Multicellular Process;mutant;Nature;New Territories;Noise;Nutrient;Outcome;pathogen;Pathway interactions;Periodicity;Phenotype;Population;Positioning Attribute;Predatory Behavior;Process;Production;quorum sensing;Reporter;Resolution;response;Role;Second Messenger Systems;sensory input;Signal Pathway;signal processing;Signal Transduction;simulation;Source;spatiotemporal;Stimulus;Structure;success;Surface;System;Theoretical Studies;Time;Tissues;Variant;Vibrio cholerae;Virulence Factors

PROJECT_TITLE: Cell-cell interactions and the development of bacterial communities

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Aging;Biotechnology;Neurosciences

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Kinases are important regulators of biochemical processes in cells. In this project, we propose to develop single cell tools to profile kinases in the mouse and human brain to examine pathways involved in aging and Alzheimer’s Diseases. The cell type specific kinases pathways identified could lead to new targets for therapy.

PI_NAMEs: CAI, LONG  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Aging;Alzheimer's Disease;Biochemical Pathway;Biochemical Process;biological systems;Brain;Cell Culture Techniques;cell type;Cells;Detection;druggable target;experimental study;Face;Genetic Transcription;Goals;Human;Learning;Maps;Measurement;Methods;Mus;Nerve Degeneration;new technology;new therapeutic target;Nucleic Acids;Pathway interactions;Phosphotransferases;Population;Protein Isoforms;Proteins;Research;RNA;single cell analysis;single cell genomics;single cell technology;technology development;Tissues;tool

PROJECT_TITLE: Single cell analysis of the kinome


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Liver Disease;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Head and Spine Injury;Urologic Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative The direct measurement of molecular transport across biological barriers like the blood-brain or blood- cerebrospinal fluid barriers in vivo would significantly expand our understanding of how therapeutics reach target organs. Moreover, it would enable the determination of important chemical structure and transport relationships to guide early stages of therapeutic drug development. Thus, motivated to obtain a comprehensive molecular understanding of drug transport across biological barriers, our work will deploy the emerging electrochemical aptamer-base sensing technology to determine with high precision the drug transport parameters of seven therapeutics across three different biological barriers.

PI_NAMEs: ARROYO CURRAS, NETZAHUALCOYOTL  (contact)

PROGRAM_OFFICER_NAME: KODURI, SAILAJA

PROJECT_TERMS: Acidity;Affect;Aminoglycosides;Amoxicillin;Ampicillin;Antibiotic Prophylaxis;Antibiotics;aptamer;Bacteria;base;Behavior;beta-Lactams;Biological;Biopsy;Blood;Blood capillaries;blood cerebrospinal fluid barrier;Brain;Brain Injuries;Brain region;carrier mediated transport;Cell Line;Cerebrospinal Fluid;Characteristics;chemical property;Chemical Structure;Chemicals;Chemoreceptors;Clinical;Complex;cost;Dangerousness;Data;Detection;Development;Dose;drug development;Drug Kinetics;Drug Transport;Endothelium;Environment;Exposure to;Extracellular Space;Family;Future;Gentamicins;Glycopeptide Antibiotics;Glycopeptides;Goals;Hippocampus;Implant;improved;In Vitro;in vivo;in vivo evaluation;in vivo monitoring;Industry;Infection;Irrigation;Kanamycin;Kinetics;Knowledge;Libraries;Liver;Maps;Measurement;Measures;Medical;Membrane;Methodology;Modeling;Molecular;Monitor;Nature;novel therapeutics;Operative Surgical Procedures;Organ;passive transport;Penetrating Brain Injury;Penetration;Penicillin G;Perfusion;Permeability;Pharmaceutical Preparations;Pharmacotherapy;Porosity;precision drugs;predictive modeling;Preparation;prevent;programs;Prophylactic treatment;Prostate;Prostatic;Rattus;real time monitoring;Regimen;Research;Research Personnel;Resistance development;Resources;response;Sampling;sensor;sensor technology;side effect;standard of care;Structure;Structure of jugular vein;temporal measurement;Testing;Thalamic structure;Therapeutic;Therapeutic Agents;therapeutically effective;Time;Tissues;Tobramycin;Transport Process;Travel;tumor;uptake;Vancomycin;Work;wound

PROJECT_TITLE: In-Vivo Monitoring of Therapeutic Drug Transport Across Biological Barriers

STUDY_SECTION: XNDA

STUDY_SECTION_NAME: Xenobiotic and Nutrient Disposition and Action Study Section[XNDA]


ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Wiskott-Aldrich syndrome (WAS) is associated with high mortality from infections, autoimmunity, and cancer. We have uncovered a new mechanism for disease causation that pertains to how WASp enables cells to manage DNA stress, which we will fully characterize in this project.

PI_NAMEs: VYAS, YATIN M (contact)

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Actins;Adaptor Signaling Protein;Address;ANGPTL2 gene;Autoimmunity;autoinflammation;autoreactivity;Biological;biological adaptation to stress;cancer predisposition;Cell Lineage;Cell membrane;Cell Nucleus;Cell Physiology;Cell Survival;Cells;Child;chromatin remodeling;Classification;Clinical;cofactor;Compensation;congenital immunodeficiency;Cytoplasm;Cytoskeleton;Cytosol;Databases;Defect;Deposition;Diagnosis;Disease;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Drosophila genus;Etiology;Family member;Fanconi Anemia pathway;Fanconi's Anemia;Functional disorder;G Actin;Genes;Genetic Transcription;Genome;Genome Stability;Genomic Instability;Genotype;Golgi Apparatus;homologous recombination;Human;human disease;Hybrids;hydroxyurea;Immune;Immune System Diseases;Immunodeficiency and Cancer;Impairment;Infection;Knowledge;Laboratories;Link;Lymphocyte;Malignant - descriptor;Malignant Neoplasms;Measures;Mediating;Missense Mutation;Molecular;monomer;mortality;Mus;Mutagens;mutant;Mutation;Non-Malignant;Nonsense Mutation;Normal Cell;novel;Nuclear;Organism;Paper;Pathogenicity;Pathway interactions;patient subsets;Patients;Phenotype;Plants;Play;polymerization;Polymers;Predisposition;prevent;Process;Protein Deficiency;Protein Family;protein function;Proteins;Receptor Signaling;repair function;repaired;replication factor A;replication stress;Reporting;Research;response;RNA;Role;Shapes;Signal Transduction;Single-Stranded DNA;Site;SS DNA BP;Stress;Testing;Time;Tumor Suppressor Proteins;tumorigenesis;Wiskott-Aldrich Syndrome;Wiskott-Aldrich syndrome protein;X Chromosome;Xenopus;Yeasts

PROJECT_TITLE: Defining WASp-dependent pathways in replication stress

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it focuses on elucidating the role of tyrosine kinases in mediating activity of hepatic drug transporters, which will enlighten how the phosphoproteome regulates proteins involved in drug absorption, distribution, metabolism and elimination. Once such knowledge is clarified, there is the potential significance to reduce life-threatening drug-drug interactions that are associated with reduced kinase activity and hepatic clearance. Thus the proposed research is relevant to part of the NIGMS mission that pertains to better understanding biological processes that create a foundation to advance treatment strategies.

PI_NAMEs: SPROWL, JASON A (contact)

PROJECT_TERMS: absorption;Adverse event;Affect;American;Angiotensin-Converting Enzyme Inhibitors;Binding;Biological Assay;Biological Markers;Biological Process;Cell model;Clinical;Dangerousness;design;Drug Interactions;Drug Kinetics;Drug Prescriptions;Drug usage;Enzymes;experience;Exposure to;Foundations;genetic manipulation;genetic variant;Goals;Hepatic;Hepatocyte;Human;In Vitro;in vivo;inhibitor;innovation;insight;Investigational Drugs;kinase inhibitor;knock-down;Knowledge;Lead;Life;liquid chromatography mass spectrometry;Liver;LYN gene;Mass Spectrum Analysis;Measures;Mediating;Mediator;Metabolism;Methotrexate;Mission;Modeling;Molecular;mouse model;Mus;Mutation;National Institute of General Medical Sciences;novel therapeutics;OATP Transporters;Organic Cation Transporter;outcome prediction;overexpression;Pathway interactions;patient response;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacologic Substance;Phosphorylation;Phosphorylation Site;Phosphotransferases;Physiological;Plasma;Positioning Attribute;Post-Translational Protein Processing;Post-Translational Regulation;prevent;Process;Protein Tyrosine Kinase;Proteins;Proteomics;Public Health;Regulation;Reporting;Research;Rhabdomyolysis;RNA interference screen;Role;rosuvastatin;src-Family Kinases;Substrate Interaction;Testing;Therapeutic;therapeutic development;Toxic effect;Transgenic Organisms;treatment response;treatment strategy;Tyrosine;Tyrosine Kinase Inhibitor;Tyrosine Phosphorylation;Tyrosine Phosphorylation Site;United States Food and Drug Administration;uptake;Xenobiotics

PROJECT_TITLE: Regulation of hepatic uptake transporters by tyrosine kinases


NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The microscopic examination of stained tissue is a fundamental component of biomedical research, disease diagnosis, prognosis and therapeutic response prediction. However, the subjective interpretation of histology sections is subject to large interobserver and interobserver variability. This project focuses on developing artificial intelligence algorithms for the objective and automated analysis of whole histology slides leading to the development of an easy-to-use open source software package for biomedical researchers.

PI_NAMEs: MAHMOOD, FAISAL  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Algorithms;artificial intelligence algorithm;automated analysis;automated image analysis;Biological Process;Biomedical Research;cancer diagnosis;Classification;Clinical;clinical decision-making;Computer software;Computer Vision Systems;data fusion;decision research;deep learning;deep learning algorithm;deep learning model;design;Development;Diagnosis;Diagnostic;Discipline;Disease;disease diagnosis;experience;Forensic Medicine;Funding;Heart;Histology;Histopathology;Image;Image Analysis;improved;Interobserver Variability;Intraobserver Variability;Label;Laboratories;Laboratory Research;Manuals;Methods;Microscopic;microscopic imaging;Molecular Profiling;Multiomic Data;novel;online resource;open source;Organ;Outcomes Research;Pathology;pathology imaging;Play;pre-trained model;Prediction of Response to Therapy;Prognosis;prognostic;Research;Research Personnel;Slide;success;System;Tissue Stains;training data;United States National Institutes of Health;user-friendly;Validation;Visualization

PROJECT_TITLE: Interpretable Deep Learning Algorithms for Pathology Image Analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-N(55)R]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Genetics;Heart Disease;Hypertension;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

PHR: PROJECT NARRATIVE Recent studies found that treating high blood pressure to a lower target reduces the risk of heart disease, stroke, and death, but the benefits and risks of lower blood pressure targets may differ from person to person. These projects will explore whether the health of mitochondria, the structures that convert energy into a form the body can use, affects the benefits or risks of lower blood pressure targets. The knowledge gained will help clinicians to personalize the treatment of high blood pressure, which could reduce the burden of heart disease among millions of individuals worldwide.

PI_NAMEs: JOTWANI, VASANTHA KOLAVENNU (contact);ODDEN, MICHELLE CHRISTINA;TRANAH, GREGORY J.

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Adoption;Adult;Adverse effects;adverse event risk;adverse outcome;Affect;Age;age related;age-related disease;Aging;aging related;Animal Model;Anti-Hypertensive Agents;Benefits and Risks;Bioenergetics;Blood;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure intervention;blood pressure reduction;Body Composition;Calibration;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Data;clinical risk;cognitive function;data integration;Dementia;Diabetes Mellitus;Discrimination;DNA;Elderly;Electrolytes;Energy Metabolism;Equilibrium;Event;falls;frailty;Fresh Tissue;functional status;genomic data;Genomic Instability;Genomics;Glean;Goals;Guidelines;hallmarks of aging;Health;heart disease risk;Heart Diseases;high risk;Human;Hypertension;hypertension treatment;hypertensive;hypoperfusion;Hypotension;Impaired cognition;Individual;Individual Differences;Inherited;innovation;insight;Intervention Trial;Knowledge;lifestyle intervention;Link;Machine Learning;machine learning method;Measures;Methods;mild cognitive impairment;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial dysfunction;mitochondrial genome;mitochondrial metabolism;Modeling;mortality;mortality risk;Mutation;Nerve Degeneration;neural network;Neurodegenerative Disorders;next generation sequencing;novel;Nuclear;Observational Study;older adult;Organelles;Outcome;Participant;Pathway interactions;patient subsets;Performance;personalized intervention;personalized medicine;Persons;Physical Function;Play;precision medicine;randomized trial;Recommendation;response;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;Role;Safety;Stress;stressor;Stroke;Structure;Subgroup;Syncope;Technology;Testing;tool;treatment effect;United States National Institutes of Health;Variant;walking speed;Work

PROJECT_TITLE: Mitochondrial health, cardiovascular risk, and blood pressure targets in hypertensive adults

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE – RELEVANCE TO PUBLIC HEALTH The role of the immune system in healthy individuals is to prevent infected or malignant cell outgrowth, however patients with cancer often have defects in this surveillance system. This proposal investigates the reprogramming of innate lymphoid cell development in leukemia, specifically focusing on a particular defect in our immune system that allows cancer to evade detection. In addition, we will explore a novel therapeutic combination to restore this defect and improve immune cell responses in patients with cancer.

PI_NAMEs: MUNDY-BOSSE, BETHANY  (contact);OAKES, CHRISTOPHER C.

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Aberrant DNA Methylation;Acute Myelocytic Leukemia;acute myeloid leukemia cell;adaptive immune response;Address;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Automobile Driving;cancer cell;CD34 gene;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;Cellular biology;Cessation of life;Coculture Techniques;cytokine;cytotoxic;Data;Defect;Detection;Development;Disease;Disease Progression;disorder control;DNA Methylation;Environment;Epigenetic Process;epigenetic regulation;epigenome;epigenomics;Equilibrium;Evaluation;Family;Gene Expression Profile;Generations;genome-wide;Hematologic Neoplasms;Hematopoietic stem cells;Homeostasis;Immune;immune activation;Immune Evasion;Immune system;Immune System Diseases;Immunity;Immunocompetent;Immunologic Surveillance;Immunophenotyping;Immunotherapeutic agent;improved;improved outcome;In Vitro;in vivo Model;Individual;inhibitor;innate immune mechanisms;Innate Immune Response;Innate Immune System;Investigation;leukemia;Leukemic Cell;Leukemic Natural Killer Cell;Lymphocyte;Lymphoid;Lymphoid Cell;Maintenance;Malignant Neoplasms;Maps;member;methylation pattern;Modeling;Molecular;Mus;Natural Immunity;Natural Killer Cells;novel;novel strategies;novel therapeutics;Outcome;Pathway interactions;Patients;Population;post-transplant;Pre-Clinical Model;preclinical efficacy;Precursor Natural Killer Cell;prevent;Process;Production;programs;Public Health;Receptor Activation;Receptor Inhibition;Regulation;relapse prevention;response;restoration;Role;Sampling;Series;Specific qualifier value;stem;Survival Rate;System;targeted treatment;Testing;transcription factor;Treatment Efficacy;tumor;tumorigenic;United States

PROJECT_TITLE: Dysregulation of Innate Lymphoid Immunity in Acute Myeloid Leukemia

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative This proposal describes the training and mentoring of Mr. Eric Bressler and his research project to treat solid tumors using a novel biomaterial in conjunction with a split and programmable chimeric antigen receptor (CAR) T cell system. Using this system, he describes a method for overcoming barriers to efficacy of CAR T cells in solid tumors, specifically poor T cell persistence in the tumor microenvironment, lack of specific antigens, and treatment-limiting adverse effects. The capability of this novel therapeutic system to promote CAR T cell proliferation, prevent antigen escape, and mitigate adverse events will be evaluated.

PI_NAMEs: BRESSLER, ERIC  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adaptor Signaling Protein;Address;Adverse effects;Adverse event;Animal Model;Antibodies;Antigen Targeting;Antigens;Beds;Biocompatible Materials;Biodistribution;Biological Availability;bioluminescence imaging;Bone Marrow;Breast Cancer Model;CAR T cell therapy;CD3 Antigens;Cell Line;Cell Therapy;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Chitosan;Clinical Medicine;Clinical Skills;Communication;Coupling;CRISPR/Cas technology;cytokine;cytokine release syndrome;cytotoxic;Data Analyses;density;Deposition;design;Development;Development Plans;draining lymph node;Drug Delivery Systems;efficacy evaluation;Encapsulated;engineered T cells;ERBB2 gene;Excision;exhaustion;Exhibits;Goals;Growth;Hematologic Neoplasms;Immune response;Immunology;Immunotherapy;Implant;implantation;improved;In Vitro;in vivo;Individual;insight;Interdisciplinary Study;Interleukin-15;Knock-out;Knowledge;Laboratories;Leucine Zippers;Logic;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Methods;Modality;Modeling;Molecular Biology;Monitor;Monoclonal Antibodies;mouse model;multidisciplinary;Mus;nanofiber;nanopolymer;novel;novel therapeutics;Operative Surgical Procedures;Organ;Physicians;Population;prevent;Prevention;programmed cell death protein 1;Proliferating;Proteins;Reporting;Research;Research Personnel;Research Project Grants;Risk Reduction;ROR1 gene;Safety;scaffold;Scientist;Shapes;Signal Transduction;Site;SKBR3;skills;Solid Neoplasm;spatiotemporal;Specificity;Spleen;stem cells;success;Surface;Surgical Mesh;Surgical sutures;Surgically-Created Resection Cavity;System;T cell anergy;T cell therapy;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Techniques;Testing;therapy development;Tissues;Toxic effect;Training;tumor;Tumor Antigens;Tumor Debulking;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: Development of a Surgical Drug Delivery System for Enhancement of CAR T Cell Activity


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: EUGENE

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: Project Narrative Single-molecule fluorescence methods have revolutionized the analysis of RNA structure and dynamics, but measurements can typically be performed on only one RNA sequence at a time. We will develop a high-throughput approach that uses in situ sequencing to extract single- molecule data for individual sequences in a randomized pool. We will utilize this approach to investigate the effects of mutations on RNA processing and to improve algorithms that predict RNA structure.

PI_NAMEs: WIDOM, JULIA REED (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adopted;Bacteria;base;Benchmarking;Biological Process;Biophysics;catalyst;Conserved Sequence;Data;Disease;Fluorescence;Gene Expression;Goals;improved;In Situ;in situ sequencing;Individual;insight;interest;Kinetics;Length;Ligand Binding;Maps;Measurement;Measures;Methods;Monitor;Mutation;Nature;Play;prediction algorithm;Process;programs;Property;Proteins;Randomized;Research;response;RNA;RNA analysis;RNA Folding;RNA library;RNA Processing;RNA Sequences;RNA Splicing;RNA, Messenger, Splicing;RNA-Protein Interaction;Role;Signaling Molecule;single molecule;single-molecule FRET;Site;Spectrum Analysis;Stimulus;Structure;Techniques;Thermodynamics;Time

PROJECT_TITLE: Mapping the sequence landscape of RNA structure, dynamics and protein interactions using high-throughput single-molecule FRET


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Estrogen;Neurosciences;Rehabilitation;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: PROJECT NARRATIVE A major concern of breast cancer survivors is cognitive dysfunction associated with cancer treatment. This study will provide an unprecedented opportunity to understand the effects of newer hormonal therapies used to treat breast cancer, which will inform risk-benefit analyses for the large number of hormone-positive breast cancer patients eligible for these treatments. The study results will inform the medical community about the unintended harms of different strategies to treat breast cancer among a representative, diverse population.

PI_NAMEs: NATTINGER, ANN B (contact);PEZZIN, LILIANA E.

PROGRAM_OFFICER_NAME: GREEN, PAIGE A

PROJECT_TERMS: Address;Adjuvant;Adjuvant Therapy;Adverse effects;Affect;Aftercare;Age;Alzheimer's Disease;Androgens;Area;Aromatase;Aromatase Inhibitors;Autopsy;Benefits and Risks;Brain;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer survivor;Breast Cancer Treatment;cancer diagnosis;Cancer Survivor;Cancer Survivorship;cancer therapy;cancer-related cognitive impairment;Caring;Cessation of life;Characteristics;chemotherapy;Clinical;Clinical Trials;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;Communities;comparison control;Cross-Sectional Studies;Data;Data Sources;deprivation;Diagnosis;Disease;Education;Effectiveness;Eligibility Determination;Enzymes;Estrogen Antagonists;Estrogen Receptors;Estrogens;Exhibits;Exposure to;functional improvement;Future;Goals;Guidelines;Health and Retirement Study;health data;hormone receptor-positive;hormone therapy;Hormones;Human;Impaired cognition;inhibitor therapy;innovation;interest;Intervention;Late Effects;Life;Literature;Longitudinal Studies;Longitudinal Surveys;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Medical;Medicare;neural;Neuropsychology;novel;Operative Surgical Procedures;Parameter Estimation;Patient Care;Patients;Performance;Persons;Pharmacologic Substance;Population;Population Heterogeneity;Postmenopause;Predisposition;premalignant;Prospective, cohort study;Quality of life;Recurrent disease;Research Design;sociodemographics;Time;Tissues;Treatment outcome;Woman;women's diagnosis;women's treatment;Work

PROJECT_TITLE: A longitudinal, nationally representative study of cognition-related effects of breast cancer and its treatment

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases;Rehabilitation;Rett Syndrome;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: PROJECT NARRATIVE This study will provide insight into how targeted deep brain stimulation (DBS) improves the maturation of hippocampal newborn neurons and the mechanisms underlying DBS-induced motor benefits in a mouse model of Rett syndrome. Pinpointing the underlying mechanisms of DBS at the neuronal and circuit levels is critical to understanding behavioral changes and will provide a framework for developing future interventions.

PI_NAMEs: TANG, JIANRONG  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Adult;Affect;Affective;Alzheimer's Disease;Automobile Driving;Basal Ganglia;Behavioral;Brain;Cell Nucleus;Cells;Child;Chronic;Cognition;Corpus striatum structure;Data;Deep Brain Stimulation;dentate gyrus;Dopamine;dopaminergic neuron;Dorsal;Electrophysiology (science);Etiology;Female;Fimbria of hippocampus;Frequencies;Future;gamma-Aminobutyric Acid;Ganglia;Generations;Genetic;Globus Pallidus;Hippocampus;Impairment;improved;insight;Intellectual functioning disability;Intervention;Link;Medial;Membrane;Memory;Methyl-CpG-Binding Protein 2;Midbrain structure;Moods;Morphology;mosaic;Motor;Motor Cortex;motor disorder;motor function improvement;motor learning;motor symptom;mouse model;Movement;Movement Disorders;Mus;neural circuit;Neurodevelopmental Disorder;neurogenesis;Neurons;neuropsychiatric disorder;Newborn Infant;newborn neuron;optogenetics;Pathway interactions;Physiology;Property;Regimen;Rett Syndrome;Role;signal processing;Signal Transduction;Substantia nigra structure;Synapses;Synaptic plasticity;Synaptic Transmission;Testing;Therapeutic;X Inactivation

PROJECT_TITLE: Studying the effects and mechanisms of deep brain stimulation in Rett syndrome mice

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Lyme Disease;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Lyme disease is caused by a tick transmitted bacteria (B. burgdorferi), but must pass through a rodent host to complete its life cycle. P. leucopus is the preferred rodent host for this and other vector borne diseases. Genome wide association studies in P. leucopus will identify and validate (via Cas9-based knockouts) genes that mediate the compentency of P. leucopus to serve as a host for B. burgdoreri and other disease causing agents. Genes may suggest treatment options and/or strategies to slow disease spread.

PI_NAMEs: BARBOUR, ALAN G.;LONG, ANTHONY DOUGLAS (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Adult;Animals;Antibodies;ATAC-seq;Bacteria;Biological;Biological Models;Blood;Borrelia burgdorferi;Breeding;Candidate Disease Gene;Chiroptera;Chromatin;Chromosome Mapping;Chromosomes;chronic infection;cohort;combat;Communities;Competence;Coupled;CRISPR gene drive;CRISPR/Cas technology;Data;Deer Mouse;Development;Diploidy;Disease;Disease Notification;Ebola virus;Enhancers;Equilibrium;Euthanasia;experimental study;Female;foot;forward genetics;Gene Targeting;Genes;Genetic;genetic approach;genetic architecture;Genetic Crosses;Genetic Models;Genetic Structures;Genome;genome annotation;genome browser;genome wide association study;genome-wide;Genomic Segment;Genomics;Genotype;Goals;Growth;Haplotypes;High Prevalence;Human;Immune response;Immunity;Infection;Inflammation;insight;inter-individual variation;interest;Intervention;Knock-out;knockout gene;Larva;Life Cycle Stages;Linkage Disequilibrium;Lyme Disease;male;Mammals;Measurement;Measures;Mediating;microbial;Modeling;Molting;Muridae;Mus;North America;Nymph;Organ;Parasites;pathogen;Pathology;Peromyscus;Persons;Phenotype;Population;Prevalence;primary endpoint;Process;promoter;rate of change;Resources;Rodent;Rodent Model;Role;Sample Size;SARS coronavirus;secondary endpoint;segregation;Skin;success;tick transmission;tick-borne;Tick-Borne Diseases;Ticks;Time;Tissues;trait;Transgenic Model;Transgenic Organisms;transmission blocking;United States;Variant;Vector-transmitted infectious disease;Wild Animals

PROJECT_TITLE: Genetic architecture of host response to tickborne disease in Peromyscus leucopus

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative This project seeks to develop proteins and enzymes that are switched on and off by binding of specific DNA or RNA sequences, as well as by proteins and small molecules. These protein switches will be used as biosensors for detecting pathogens and disease markers, and to selectively kill virally-infected cells while leaving uninfected cells unharmed.

PI_NAMEs: LOH, STEWART N (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: Acceleration;Address;Antibodies;aptamer;Bacillus amyloliquefaciens ribonuclease;Base Sequence;BCAR1 gene;Binding;Biological;Biological Markers;Biology;Biophysics;Biosensor;Bone Marrow Stem Cell;Calcium;Calcium Signaling;Calmodulin;Cause of Death;Cells;Cellular Phone;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;Complex;Computing Methodologies;Cytomegalovirus;cytotoxic;design;Devices;Disease;Disease Marker;DNA;DNA Binding;DNA Binding Domain;DNA Sequence;Engineering;Enzymes;Exhibits;experimental study;Family;Fibronectins;Fluorescence;Fluorescence Resonance Energy Transfer;frontier;gene editing technology;Genes;Goals;Guide RNA;Human;Human Activities;Immunocompromised Host;Individual;Kinetics;Ligand Binding;Ligands;Ligation;link protein;luminescence;Mediating;Methodology;Modification;Molecular Conformation;Monitor;monocyte;Morbidity - disease rate;mortality;nanoluciferase;Nature;Nucleic Acid Binding;nucleic acid binding protein;Nucleic Acids;Outcome;Output;pathogen;Pathogen detection;Pathway interactions;point-of-care detection;prevent;Protein Conformation;Protein Engineering;Protein Family;protein folding;protein function;Proteins;Proteome;ratiometric;Reaction Time;Regulation;Research;response;Ribonucleases;RNA;RNA Binding;RNA Sequences;scaffold;sensor;simulation;small molecule;Source;System;Technology;Therapeutic;tool;Toxin;Transplant Recipients;Transplantation;Variant;Viral

PROJECT_TITLE: Combining protein and DNA engineering to create bioswitches

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE The goals of this project are to continue the New England Gastroparesis Collaborative to enroll patients in the NIH Gastroparesis Consortium where patients will then be entered into studies which are performed at multiple sites. We are planning for a multicenter Cognitive Behavioral Therapy in Gastroparesis Trial (COBIG 2.0) to reduce symptom burden.

PI_NAMEs: KUO, BRADEN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdomen;acceptability and feasibility;Address;Anxiety;avoidant restrictive food intake disorder;Behavioral;behavioral health;behavioral health intervention;Biological;biopsychosocial;biopsychosocial factor;Caring;Central Nervous System;central sensitization;Chronic;Clinical;Clinical Research;Clinical Trials;Cognitive Therapy;Complex;Defect;dietary restriction;Disease;disorders of gut-brain interaction;early satiety;Eating;efficacious treatment;Elements;Enteral;Enteric Nervous System;Epidemiology;follow-up;food avoidance;Functional disorder;Functional Gastrointestinal Disorders;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal symptom;Gastroparesis;General Hospitals;Goals;GPR4 gene;Health;health care service utilization;improved;indexing;innovation;Intervention;Irritable Bowel Syndrome;Maintenance;Massachusetts;Medical;Morbidity - disease rate;mortality;Motor;motor disorder;Multicenter Studies;Natural History;Nature;Nausea and Vomiting;Neurobiology;neuroregulation;New England;novel;Pain;participant enrollment;Pathology;patient registry;Patient Self-Report;Patients;Peripheral;Phenotype;precision medicine;primary endpoint;profiles in patients;Protocols documentation;psychologic;Pyloric sphincter structure;Quality of life;Randomized, Controlled Trials;recruit;reduce symptoms;Registries;Research;research study;restrictive eating;Role;Screening procedure;secondary endpoint;Sensory;Severities;Site;Symptom Burden;Symptoms;targeted treatment;Testing;Therapeutic;Treatment outcome;United States National Institutes of Health;Validation;video delivery;Visceral

PROJECT_TITLE: New England Gastropareis Consortium: Neurobiology of Gastroparesis


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Rehabilitation

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Deep brain stimulation (DBS) is an effective neurosurgical intervention that can significantly reduce the burden of Parkinson's disease, however, there is currently no reliable way to predict which patients will benefit most from the therapy. In this project, we propose to evaluate how useful MRI brain images are for predicting DBS effectiveness and risk for side-effects. The results will have strong potential for improving the way clinicians choose the optimal DBS candidate and surgical brain target, while ensuring that resources are only directed toward patients who are most likely to benefit.

PI_NAMEs: MORRISON, MELANIE A (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Area;Basal Ganglia;Brain;Brain imaging;brain iron;brain surgery;burden of illness;candidate selection;Clinical;clinical predictors;Cognitive;cognitive ability;connectome;Data;Deep Brain Stimulation;density;Development;Diffusion Magnetic Resonance Imaging;Effectiveness;Electrodes;Ensure;Equilibrium;experience;feature selection;Functional Magnetic Resonance Imaging;Ganglia;Globus Pallidus;Goals;Image;Implant;improved;Individual;Intervention;Iron;Location;Magnetic Resonance Imaging;Maps;Measures;Modality;model building;Modeling;Motor;motor symptom;neuroregulation;neurosurgery;novel;Operative Surgical Procedures;Outcome;outcome prediction;Parkinson Disease;Pathologic;patient population;patient subsets;patient variability;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Play;Positioning Attribute;Postoperative Period;pragmatic implementation;predictive modeling;Predisposition;prognostic;prognostic tool;Radar;Reporting;Resources;response;Risk;Role;screening;Severity of illness;side effect;Structure;Structure of subthalamic nucleus;symptomatic improvement;Symptoms;Techniques;Thalamic structure;Therapeutic;Tissues;tool;Treatment Efficacy

PROJECT_TITLE: MULTIMODAL MRI TO PREDICT DBS MOTOR AND COGNITIVE OUTCOMES IN PARKINSON’S DISEASE

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention;Rare Diseases

ORG_CITY: LAWRENCE

ORG_NAME: UNIVERSITY OF KANSAS LAWRENCE

ORG_STATE: KS

PHR: Project Narrative This natural history study examines development in children with FXS from ages 2 - 26 years as well as changes in their mothers' mental health and executive function. We use a longitudinal design to identify variables that predict young adult outcomes and maternal changes over time and in transition to adulthood.

PI_NAMEs: BRADY, NANCY CAROLINE (contact)

PROGRAM_OFFICER_NAME: KAU, ALICE S

PROJECT_TERMS: Adaptive Behaviors;Address;Adolescence;Adolescent;adolescent health;Adult;Advocacy;Age;aging process;Anxiety;Area;autism symptoms;Behavior;Biological;Biological Markers;Biology;Body mass index;Caregiver Burden;CGG repeat;Child;Child Behavior;Child Health;Child Rearing;Cognition;Cognitive;Collaborations;Communication;Communities;Data;Data Collection;Data Set;Development;early childhood;Education;emerging adult;Employment;Employment Status;Environment;executive function;expectation;experience;Family;FMR1 gene;FMR1 Premutation;Friendships;Goals;Growth;Home;Human;Impaired cognition;improved;Individual;insight;Intervention;Kansas;Language;Life;life span;Literature;Living Arrangement;longitudinal design;Measures;Menopause;Mental Depression;Mental Health;middle childhood;Modeling;Mosaicism;Mothers;multilevel analysis;Mutation;National Institute of Child Health and Human Development;Natural History;Nature;Outcome;outcome prediction;Participant;Perception;Personal Satisfaction;Persons;Phenotype;Problem behavior;Quality of life;recruit;Request for Applications;Research;research study;resilience;retention rate;Retrieval;Risk Factors;Sampling;satisfaction;Schools;Secondary Schools;Self Determination;self-reported anxiety;sex;skills;social;social engagement;Strategic Planning;Time;transition to adulthood;Uncertainty;United States National Institutes of Health;Universities;Vocation;young adult

PROJECT_TITLE: FXS: Late Adolescence and Early Adulthood

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: ROCKVILLE

ORG_NAME: AMERICAN SOCIETY FOR BIOCHEMIS/ MOL BIOL

PHR: PROJECT NARRATIVE The American Society for Biochemistry and Molecular Biology will leverage its considerable career development resources and its engaged underrepresented scientist network to support a talented cohort of diverse K99/R00 MOSAIC scholars on the national stage. The successful execution of its MOSAIC program will contribute to stemming attrition at the key postdoc-to-faculty transition and to building a diverse life sciences workforce.

PI_NAMEs: BLOCK, KIRSTEN FLORENCE (contact)

PROGRAM_OFFICER_NAME: GIBBS, KENNETH D

PROJECT_TERMS: Academia;Accountability;Address;Advocacy;American;Applications Grants;Award;base;Biochemistry;Biological Sciences;Biomedical Research;Capital;career;career development;Career Mobility;career networking;cohort;Collaborations;Communication;Communities;Community of Practice;Complex;Dedications;Development;Discipline;editorial;Elements;Environment;evidence base;experience;Faculty;Failure;Familiarity;Fostering;frontier;Funding;Gender;Goals;Grant;Growth;Home;improved;Individual;Infrastructure;Institution;Intervention;Investments;Journals;Laboratories;Leadership;Learning;Measurable;meetings;member;Mentors;Minority;Minority Groups;minority scientist;Mission;Molecular;Molecular Biology;National Institute of General Medical Sciences;Organism;Outcome;Play;Polishes;Postdoctoral Fellow;pressure;Process;Professional Competence;Program Description;programs;Publications;Publishing;Race;Records;recruit;Research;Research Personnel;Resource Development;Resources;role model;Scholarship;Science;Scientific Societies;Scientist;skills;Social Sciences;Societies;stem;success;Talents;theories;Training;Translating;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Walking;Woman;Writing

PROJECT_TITLE: The ASBMB MOSAIC Program


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE My Home, My Health: Place- based Public Health Resources for Rural Educators will research how to attract underserved audiences to STEM, specifically rural and Native youth. This project will move past traditional information deficit models of the public understanding of science towards a public engagement with science that fosters a multi-directional dialogue incorporating varied perspectives and responding to societal issues and concerns. INBRE researchers, alongside the communities they work with, will help build locally-relevant place- based educational kits focusing on disease ecology that will improve public health awareness and provide a model for how INBRE networks can train their students to bring their research to underserved youth in authentic and engaging ways.

PI_NAMEs: AHMED, SELENA ;CORNISH, JAMIE  (contact);HAMMACK, REBEKAH ;PETERSON, ROBERT

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Address;after-school program;Alaska Native;American Indians;Awareness;Behavioral Research;Biological Sciences;Biomedical Research;Blackfeet;career;Cheyenne;Clinical Research;college;Communication;Communication Programs;Communities;community college;community engagement;community science;design;Development;Dimensions;Discipline;Disease;Disparity;Ecology;Ecosystem;Education;Education and Outreach;Educational process of instructing;Event;experience;Faculty;Female;forging;Fostering;Funding;Future;Goals;graduate student;Grant;Health;Health Resources;Home;human subject;improved;informal learning;Institution;interest;junior high school;Knowledge;learning outcome;Low income;Measures;member;Modeling;Montana;Native Americans;native youth;Outcome;outreach;pathogen;programs;Protocols documentation;public engagement with science;Public Health;Randomized, Controlled Trials;Reporting;Research;research based learning;research faculty;Research Personnel;Reservations;Resources;Rural;rural Americans;rural underserved;Salish Kootenai College;Schools;Science;Science, Technology, Engineering and Mathematics Education;Scientist;Series;skills;statistics;student participation;Students;success;Training;translational research program;tribal college;Tribes;undergraduate student;Underrepresented Populations;United States National Institutes of Health;Universities;university student;Visit;women of color;Work;workforce needs;Youth

PROJECT_TITLE: My Home, My Health: Place-Based Public Health Resources for Rural Educators

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(56)R]