ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Public Narrative In multicellular organisms, distant cells can readily exchange information by sending out signals via molecules enclosed in nano-sized extracellular vesicles and particles (EVPs). EVPs are involved in the pathogenesis of diverse diseases including cancer and provide an attractive disease marker for non-invasive early disease detection. A high throughput optical nanotweezer and enhanced Raman spectroscopy technology will be developed for understanding the heterogeneity of single nanosized EVPs.

PI_NAMEs: NDUKAIFE, JUSTUS CHUKWUNONSO (contact)

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Address;Biological;Biological Assay;Cells;Collection;Communication;design;Detection;Diameter;Disease;disease diagnosis;Disease Marker;Distant;extracellular;extracellular vesicles;Future;Heterogeneity;high throughput technology;improved;Individual;individual variation;laser tweezer;Light;Lipids;Malignant Neoplasms;Masks;Mass Spectrum Analysis;Methods;Molecular;nanoparticle;nanoplasmonic;nanoscale;nanosized;Nature;next generation;Nobel Prize;novel;Nucleic Acids;optic tweezer;Optics;Organism;parallelization;particle;Pathogenesis;Physics;programs;Proteins;Raman Spectrum Analysis;Research;RNA;Role;Signal Transduction;Structure;Techniques;Technology;Therapeutic;tool

PROJECT_TITLE: Understanding the Heterogeneity of Nanoscale Extracellular Vesicles, Exomeres, and Supermeres using Next Generation Optical Nanotweezers

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Loss of empathy is a core symptom of behavioral variant frontotemporal dementia (bvFTD) that negatively impacts daily functioning and is highly distressing to families and caregivers. A relatively unexplored but promising avenue of scientific inquiry is the role of autonomic nervous system (ANS) activity in empathy loss in bvFTD. The overarching goal of this project is to use a smartwatch to identify abnormalities in autonomic activity that are robustly associated with empathy loss in bvFTD and validate digital markers of autonomic abnormalities against behavioral measures of empathy loss and neuroimaging of the salience network.

PI_NAMEs: RHODES, EMMA  (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Accelerometer;Address;Adult;Age;Anterior;Area;Arousal;Atrophic;Autonomic nervous system;Behavior;behavior measurement;Behavioral;Behavioral Symptoms;behavioral variant frontotemporal dementia;Caregiver Burden;Caregivers;cingulate cortex;Classification;Clinical;clinical diagnosis;Cognitive;cognitive function;Collaborations;Cues;daily functioning;Data;Dementia;design;Detection;detector;Development;Devices;diagnostic accuracy;digital;Digital biomarker;digital data;digital monitoring;Distress;Early Diagnosis;early onset;Electrocardiogram;Emotional;Emotions;Empathy;Environment;Family;feature selection;frontotemporal degeneration;Functional disorder;Functional Magnetic Resonance Imaging;Galvanic Skin Response;Goals;Impaired cognition;improved;Individual;innovation;Insula of Reil;Investigation;K-Series Research Career Programs;Knowledge;Link;Machine Learning;machine learning method;Measurement;Measures;Mediating;Mediation;Mentorship;Methodology;Methods;Modeling;Monitor;Morphologic artifacts;Motion;Movement;multimodal neuroimaging;Nervous System Physiology;network dysfunction;Neuroanatomy;Neurodegenerative Disorders;neuroimaging;neuropsychiatric symptom;Neuropsychology;novel;Output;Parasympathetic Nervous System;Participant;Pathway Analysis;Patients;Pattern;Pennsylvania;Performance;Persons;Phase;Physiological;recruit;Reporting;Research;Research Personnel;respiratory;response;Rest;Role;Sampling;Scientific Inquiry;segregation;sensor;Signal Transduction;Sinus;skills;smart watch;social;social deficits;Standardization;statistical and machine learning;Statistical Methods;Stimulus;Sympathetic Nervous System;symptom treatment;Symptoms;Technology;Testing;Training;Universities;wearable device;wristband

PROJECT_TITLE: Digital monitoring of autonomic activity to detect empathy loss in behavioral variant frontotemporal dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MEMPHIS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF TENNESSEE HEALTH SCI CTR

PHR: In an effort to overcome the ability of numerous cancers to evade the immune system, a drug lead development campaign utilizing cutting-edge drug discovery methods to identify small molecule inhibitors of the lysophosphatidic acid (LPA) subtype 5 (LPAR5) receptor is proposed. Activation of the LPAR5 subtype, blocks antitumor immunity by inhibiting activation of tumor killing by cytotoxic T lymphocytes, critical for eliminating cancer cells. Small molecule inhibitors of the LPAR5 receptor should cause a reversal of the inhibition of cytotoxic T cell activation and re- energize the anti-tumor immune response to treat immune-resistant cancer. Hit compounds identified in preliminary studies support this hypothesis and form solid premise for the project.

PI_NAMEs: AUGELLI-SZAFRAN, CORINNE ELIZABETH;LEE, SUE CHIN ;TIGYI, GABOR J (contact);TORRES, RAUL MARTIN

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: acute toxicity;Adoptive Transfer;Allogenic;analog;animal efficacy;Animals;antagonist;anti-tumor immune response;antigen-specific T cells;Antigens;Antitumor Response;beta-arrestin;Biological Assay;Breast;Breast Carcinoma;C57BL/6 Mouse;cancer cell;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;cell killing;Cellular Assay;clinical application;cytotoxic;cytotoxic CD8 T cells;Cytotoxic T-Lymphocytes;Data;design;Development;Disinhibition;Docking;drug discovery;Drug Kinetics;efficacy evaluation;efficacy study;Enhancers;Enzymes;G-Protein-Coupled Receptors;Generations;Genetic;Goals;Growth;high throughput screening;Human;human model;immune checkpoint;Immune Evasion;immune resistance;Immune system;Immunologic Surveillance;immunological synapse formation;Immunomodulators;Immunooncology;Immunotherapy;Impairment;In Vitro;in vivo;Incidence;indexing;inhibitor;Interleukin-2;iterative design;Knock-out;Knockout Mice;Lead;lead candidate;lead optimization;Liver;Lymphocyte;lymphocyte proliferation;Lymphocytic Infiltrate;Lymphoma;lysophosphatidic acid;Lysophospholipase;Macrophage;Malignant Epithelial Cell;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Melanoma;Melanoma Tumor;Metastatic Melanoma;Metastatic Neoplasm to the Lung;meter;Methods;Microsomes;Modeling;Molecular;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;Outcomes Research;Ovarian;Ovum;Pancreas;Patients;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacophore;Phenocopy;Physiological;preclinical development;Preclinical Testing;Process;Production;Proliferating;Property;Publications;Qualifying;receptor;Receptor Activation;Receptor Signaling;recruit;refractory cancer;Repression;Research;Research Personnel;Resistance;response;Role;scaffold;scale up;secondary analysis;small molecule;small molecule inhibitor;Solid;Solubility;Specificity;Structure-Activity Relationship;SUM-159 Breast Cancer Cell Line;T cell response;T-Cell Activation;T-Cell Receptor;T-Lymphocyte;Testing;therapeutically effective;tool;Toxic effect;Transforming Growth Factor alpha;Transgenic Mice;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;virtual;virtual screening;Wild Type Mouse

PROJECT_TITLE: Small molecule enhancers of tumor immunity targeting the LPA5 GPCR

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(56)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: NARRATIVE: The K24 proposal will support Dr. Robert Peck to train clinical investigators in the conduct of patient-oriented cardiovascular disease research in Tanzania and Kenya, and to conduct a new study that investigates putative biomarkers of diastolic dysfunction in people living with and without HIV in Tanzania. United States trainees will spend ~50% of their time at international research sites, which have onsite Weill Cornell faculty such as Dr. Peck, long-standing international collaborators, and outstanding environments for research training. All of the projects focus on patient-oriented research on cardiovascular disease and offer trainees a broad experience in the conduct of mentored research in the topics of global cardiovascular disease epidemiology, clinical trials and implementation science.

PI_NAMEs: PECK, ROBERT N (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Address;Adolescent;Adult;Africa;African;AIDS prevention;Ambulatory Care Facilities;Award;biobank;Biological Markers;biomarker identification;Blood Pressure;blood pressure elevation;blood pressure reduction;Cardiovascular Diseases;cardiovascular disorder epidemiology;cardiovascular disorder prevention;cardiovascular disorder risk;Caring;Chronic Disease;Clinic;Clinical;clinical implementation;Clinical Investigator;Clinical Trials;Cluster randomized trial;cohort;Communities;community engagement;Community Health Aides;community-centered;cost;cost effective;design;Development;Diagnosis;Diastolic heart failure;Disease;Echocardiography;empowerment;Environment;Event;evidence base;experience;Eye;Faculty;Family;Fellowship;follow-up;Foundations;Functional disorder;Funding;Galectin 3;Goals;Grant;Guidelines;health disparity;Heart;HIV;Hospital Mortality;Hospitalization;Hospitals;Hybrids;Hypertension;hypertension treatment;hypertensive;implementation science;implementation trial;implementation/effectiveness;improved;innovation;Institution;Interdisciplinary Study;International;Intervention;Kenya;Kidney;Leadership;Learning;Life Style;Link;Low income;medical schools;Medicine;member;Mentors;Mentorship;Mid-Career Clinical Scientist Award (K24);Modeling;Morbidity - disease rate;mortality;Myocardial dysfunction;novel;novel marker;Nursing Faculty;Organ;patient oriented;patient oriented research;Patients;Persons;Pharmaceutical Preparations;Physicians;Plasma;point of care;point of care testing;poor communities;poor sleep;Population;predictive marker;prevent;Prevention therapy;Privatization;pro-brain natriuretic peptide (1-76);Productivity;Proteins;Proteomics;Reference Standards;Religion;Research;Research Personnel;Research Project Grants;research study;Research Training;Risk Factors;risk stratification;Role;Rural;Sampling;Schools;Scientist;Site;skills;Sleep;Social Workers;Tanzania;Testing;Time;Training;training opportunity;Troponin I;Trust;United States;United States National Institutes of Health;young adult

PROJECT_TITLE: Patient-Oriented Research in Global Cardiovascular Diseases and Interactions with HIV

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Dementia;Disability Research;Neurodegenerative;Neurosciences;Pain Research;Rehabilitation

ORG_CITY: BIRMINGHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Advanced age is associated with distinct changes in physical capabilities, cognitive functions, and the experience of pain. Despite known overlap between these changes, the majority of research to date has investigated these domains separately. This project will provide an established investigator with the skills necessary to pursue future research from a perspective which integrates principles and concepts from of each of these fields; to ultimately address broader issues including recent epidemics related to relief of chronic pain and age-related cognitive disorders (e.g. mild cognitive impairment, Alzheimer’s, other dementias).

PI_NAMEs: BUFORD, THOMAS W (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Address;Advisory Committees;Affective;age related cognitive disorder;Aging;Alabama;Alzheimer's Disease;Area;Award;Biometry;biopsychosocial;Brain;career;Cephalic;Chronic;Chronic low back pain;chronic pain;chronic pain relief;Cognition;Cognition Disorders;Cognitive;cognitive function;cognitive neuroscience;Cohort Studies;Collaborations;Complex;Coupled;Creativeness;Data;Data Collection;Data Sources;Degenerative polyarthritis;Dementia;design;Development;disability;Disability prevention;Doctor of Philosophy;Educational Curriculum;Educational workshop;Elderly;Epidemic;Exercise;experience;Funding;Future;Gait speed;Goals;Health;health management;healthy aging;human old age (65+);Hypertension;Impaired cognition;improved;Independent Scientist Award;indexing;innovation;interdisciplinary approach;Interdisciplinary Study;International;knee pain;Knowledge;Knowledge acquisition;Laboratories;laboratory experience;late life;Leadership;Learning;Literature;Maintenance;Medicine;meetings;Mentors;Methods;mid-career faculty;mild cognitive impairment;Morbidity - disease rate;mortality;National Institute on Aging;Neck;novel;older adult;Older Population;opioid abuse;Outcome;Oxygen;Pain;Pain management;pain reduction;Pain Threshold;Persons;Pharmacological Treatment;Physical Exercise;Physical Function;Pilot Projects;Population;Positron-Emission Tomography;preservation;programs;prospective;Prospective Studies;Psychology;Psychosocial Factor;Publications;Quality of life;racial population;Randomized, Controlled Trials;Recording of previous events;Research;Research Personnel;research study;Science;Scientist;Sensory;Site;skill acquisition;skills;success;symposium;Testing;Therapeutic;therapy design;Time;Training;Training Programs;Universities;Virginia

PROJECT_TITLE: Interconnections among Cognition, Pain, and Physical Function in Aging.

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The storage and future research use of newborn bloodspots has itself experienced a long history of national controversy given that state newborn screening programs do not obtain informed consent for collection and testing, and only a few states have subsequently added consent for the research use of leftover bloodspots. Ongoing lawsuits among some state programs and policy debates at both the state and federal levels have further mired any progress to promote the use of newborn screening bloodspots for important health research, including studies that assess health disparities. We will address this national problem using an implementation science framework to assess consenting quality and implement an electronic consent progress within hospitals serving diverse and underserved populations for the retention and research use of residual dried bloodspots.

PI_NAMEs: GOLDENBERG, AARON J;ROTHWELL, ERIN  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Address;Adoption;Attitude;biobank;Blood;Blood Screening;Characteristics;Child;Clinical;Collection;Communities;Conflict (Psychology);Consent;Control Groups;Data;Decision Making;Dryness;efficacy evaluation;electronic consent;Electronics;Environment;Evidence based practice;experience;Focus Groups;follow-up;General Population;genome resource;Goals;Group Processes;Health;health assessment;Health Benefit;health disparity;Health system;Hospitals;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;Individual;Infant;Informed Consent;Institution;Intervention;Interview;Knowledge;Logic;member;Methods;Michigan;Modeling;Neonatal Screening;Newborn Infant;novel;Outcome;Outcomes Research;Parents;Participant;patient population;Patient-Focused Outcomes;Patients;Policies;Population;population health;Population Heterogeneity;postnatal;precision medicine;Process;programs;prospective;Recommendation;Recording of previous events;Regrets;repository;Research;Research Assistant;Research Personnel;Residual state;Resources;routine care;Sampling;satisfaction;screening program;Services;Spanish;Specimen;Spottings;Surveys;System;Technology;technology platform;Testing;tool;Translational Research;Trust;Underrepresented Populations;Underserved Population;virtual

PROJECT_TITLE: Implementing a Novel Consent Process for Biospecimen Research after Newborn Screening in Hospitals Serving Diverse Patients


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine;Prevention;Rare Diseases;Sleep Research

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE The importance of early disease detection in Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) is demonstrated by the failure of promising clinical trials to slow disease progression, quite possibly because those interventions occur when the disease is already established and too advanced. In the current grant period, we have identified highly predictive biomarkers in the spinal fluid and on MRI imaging that allow for predicting a future diagnosis of PD/DLB or MSA when the disease is still at a limited stage without motor or cognitive symptoms or signs. We now propose in this renewal application to apply these promising markers to an even earlier stage, when only sleep abnormalities are present (REM sleep behavior disorder), in order to allow for detection of these neurodegenerative diseases at a prodromal stage.

PI_NAMEs: SINGER, WOLFGANG  (contact);VEMURI, PRASHANTHI

PROGRAM_OFFICER_NAME: SWANSON-FISCHER, CHRISTINE R

PROJECT_TERMS: advanced disease;alpha synuclein;American;associated symptom;behavioral neurology;Biological Markers;biomarker evaluation;biomarker identification;Categories;Cerebellar Ataxia;Cerebrospinal Fluid;Clinical;Clinical Trials;Cognitive;Cognitive deficits;cohort;Collaborations;Data;Databases;Dementia with Lewy Bodies;Detection;Diagnosis;Diffusion;Disease;Disease Progression;Early Diagnosis;Enrollment;Failure;falls;Functional disorder;Funding;Future;Goals;Grant;high risk;Image;imaging biomarker;Institution;Intervention;Laboratories;Lewy Body Disease;Limited Stage;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Medicine;Modification;morphometry;Motor;motor deficit;motor symptom;Movement Disorders;Multiple System Atrophy;Neurobehavioral Manifestations;Neurocognitive Deficit;Neurodegenerative Disorders;Neurons;novel;Parkinson Disease;Parkinsonian Disorders;Participant;participant enrollment;patient stratification;Patients;Pattern;Phenotype;phenotypic biomarker;Positioning Attribute;pre-clinical;predictive marker;Predictive Value;prospective;Pure Autonomic Failures;recruit;REM Sleep Behavior Disorder;research clinical testing;Resources;Severities;Sleep;sleep abnormalities;Symptoms;synucleinopathy;Testing;Therapeutic;Therapy trial;Translating;Validation

PROJECT_TITLE: Synucleinopathies – Novel Targets in Early Diagnosis, Pathophysiology, and Therapeutic Approach

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Pediatric

ORG_CITY: HERSHEY

ORG_DEPT: PATHOLOGY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: PROJECT NARRATIVE The Penn State PROMISE program (Penn State Research training in Oncology and Medicine to Inspire Student Engagement) is an holistic approach to inspire, attract, and retain the next generation of cancer researchers and oncologists. PROMISE will instill in participants a gestalt understanding of cancer as a disease (how it is prevented, controlled, and treated), while stimulating interest in oncology careers and providing the skills needed for durable research careers. In the long-term, PROMISE will promote a deep and life-long understanding of how cancer research impacts the lives of individuals in the 21st century, which will drive the on-going discovery of new knowledge by retaining a diverse cohort of trainees in cancer research careers.

PI_NAMEs: ECKERT, KRISTIN A (contact);MATTERS, GAIL L.

PROGRAM_OFFICER_NAME: ZAHIR, NASTARAN

PROJECT_TERMS: Advanced Malignant Neoplasm;Advisory Committees;anti-cancer research;base;Basic Science;Cancer Biology;career;Career Choice;Climacteric;Clinical;clinical care;Clinical Oncology;clinical practice;Clinical Sciences;cohort;college;Communities;Community Practice;design;Discipline;Disease;Educational workshop;Effectiveness;Elements;Enrollment;Environment;Evaluation;Event;experience;Faculty;faculty research;Feedback;Fertilization;Future;Goals;Health;Healthcare;holistic approach;improved;Individual;Interdisciplinary Study;interest;Knowledge;Language Development;Learning;Life;Location;Malignant Neoplasms;Medical;Medical Students;Medicine;member;Mentors;Mentorship;Modeling;Modernization;Modification;Nature;next generation;Oncologist;Oncology;Outcome;Participant;peer;peer coaching;Pennsylvania;Population;Population Sciences;prevent;Procedures;Process;programs;Public Health;Recording of previous events;recruit;Recruitment Activity;Research;Research Institute;Research Personnel;Research Training;Rewards;role model;Scientist;skills;STEM field;STEM student;student participation;Students;success;summer research;Talents;Techniques;Training;Training Support;Translating;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved students;university student

PROJECT_TITLE: Penn State Research training in Oncology and Medicine to Inspire Student Engagement (PROMISE)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Prevention;Tickborne Diseases;Vector-Borne Diseases

ORG_DEPT: BIOLOGY

PHR: This project will investigate the impact of tick seasonal activity patterns on populations of human  pathogens carried by black-legged ticks. Different seasonal activity patterns may cause dramatic changes  in parasite populations including population extinctions or explosions. The proposed research provides  the framework to investigate the impact of seasonal activity on the multitude of disease systems involving  multiple host species.

PI_NAMEs: BRISSON, DUSTIN  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Automobile Driving;Black-legged Tick;Complex;Computer Models;Data;Disease;disease transmission;disorder risk;Event;Explosion;Extinction;Frequencies;Geography;health management;human disease;human pathogen;Insect Vectors;Life;Life Cycle Stages;life history;Modeling;North America;Outcome;Parasites;pathogen;Pattern;Plants;Population;Population Dynamics;predictive modeling;Process;Public Health;Research;Seasons;Site;Statistical Models;System;Theoretical model;Tick-Borne Diseases;Ticks;Time;transmission process;Validation;Variant;Zoonoses

PROJECT_TITLE: Impacts of phenology on disease transmission dynamics


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: LA JOLLA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: Project Narrative Chromosome segregation errors cause aneuploidy, a hallmark of cancer and a major cause of birth defects and mental illness. Kinetochores execute chromosome segregation by bridging chromosomal centromeres and spindle microtubules. The proposed project will identify the molecular rules that govern kinetochore assembly and show how errors in this process can cause aneuploidy; the findings can be exploited for diagnosis and therapeutic intervention in cancer.

PI_NAMEs: DESAI, ARSHAD ;SUHANDYNATA, RAYMOND THEODORE;ZHOU, HUILIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Accounting;Acute;Address;Adult;Aneuploidy;Area;Auxins;Benchmarking;Biochemical;Biochemistry;Biological Assay;Biology;cancer cell;Cell Cycle;Cell Cycle Regulation;Cell division;Cell Extracts;Cells;Cellular biology;Centromere;Characteristics;Chromosome Segregation;Complement;Complex;Congenital Abnormality;daughter cell;Diagnosis;Disasters;DNA;DNA-Directed DNA Polymerase;Ensure;Event;experimental study;flexibility;Genetic;Genome;Goals;Health;Human;innovation;interest;Isotopes;Kinetochores;Life;macromolecular assembly;Malignant Neoplasms;Mass Spectrum Analysis;Mental disorders;Methods;Microtubules;Mitosis;Molecular;Nucleosomes;Organism;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiological;Process;Property;Protein Degradation Induction;Proteins;Proteomics;Qualifying;Reaction;reconstitution;Regulation;Research;Role;S phase;Saccharomyces cerevisiae;Signal Transduction;Site;Specific qualifier value;stable isotope;stoichiometry;System;Techniques;technology platform;Testing;Therapeutic;Therapeutic Intervention;Yeasts

PROJECT_TITLE: Kinetochore Assembly and Regulation

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Atherosclerosis;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Heart Disease;Infectious Diseases;Prevention

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Despite the clinical benefits of antiretroviral therapy, persons with HIV remain at high risk of atherosclerotic cardiovascular disease, which is a growing clinical and public health concern as the HIV population ages. This study will adapt an intervention promoting statin adherence from the general population to persons with HIV and evaluate the adapted intervention’s acceptability and feasibility by conducting a pilot in an HIV clinic. This grant will produce preliminary data and a prototype intervention for future intervention studies aiming to improve atherosclerotic cardiovascular disease prevention efforts for persons with HIV.

PI_NAMEs: DAVY-MENDEZ, THIBAUT  (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: acceptability and feasibility;Acquired Immunodeficiency Syndrome;Address;Adherence;Age;antiretroviral therapy;Atherosclerosis;atherosclerosis risk;Award;Behavior Therapy;Behavioral;Cardiology;cardiovascular disorder prevention;cardiovascular disorder risk;care providers;career;Caring;Cholesterol;Chronic;Chronic Disease;Clinic;Clinical;clinical epidemiology;co-infection;cohort;Cohort Studies;comorbidity;Consultations;cost;Data;Diabetes Mellitus;Drug Interactions;Dyslipidemias;Effectiveness;efficacy evaluation;Electronic Health Record;Epidemiology;Evaluation;Evidence based intervention;Fatigue;Frequencies;Fright;Future;General Population;Goals;Grant;Health;Health behavior;High Prevalence;high risk;HIV;human old age (65+);Impaired cognition;improved;innovation;Intervention;intervention delivery;Intervention Studies;Intervention Trial;Interview;K-Series Research Career Programs;Knowledge;Lipids;Measures;Medical;medication compliance;Mental Health;Mentors;Modeling;Morbidity - disease rate;mortality;motivational enhancement therapy;Myocardial Infarction;North Carolina;Outcome;patient oriented;Patients;Pattern;Perception;Persons;Pharmacists;Pharmacoepidemiology;Pharmacy facility;pill;Population;preference;prevent;preventive intervention;Protocols documentation;prototype;Public Health;Qualitative Research;recruit;Research;Research Methodology;Research Personnel;Resources;response;Risk;Risk Factors;risk perception;satisfaction;secondary outcome;side effect;skill acquisition;skills;social stigma;Socioeconomic Factors;Structure;substance use;Surveys;System;telehealth;Telephone;Testing;therapy adherence;Training;Training Activity;treatment adherence;treatment arm;Treatment Efficacy;United States National Institutes of Health;Universities;Viral

PROJECT_TITLE: Addressing Barriers to the Comprehensive Use of Statins in HIV: The ABACUS-HIV Study

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(MA)]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Palliative Care;Pediatric;Rehabilitation

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Treatment models applied with more than 400,000 children in out-of-home-care (OOHC) settings show limited and inconsistent effects on children’s rehabilitation and mitigation of long-term sequelae of developmental trauma. To address this concern, this project aims to develop and evaluate the Developmental Interactions Workshop Series (DIWS), a targeted professional development program that builds capacity among caregivers and care teams to improve the relational environment within the residential care milieu by increasing the breadth and frequency of developmentally enriching interaction between caregivers and children. This new approach provides a method for boosting the rehabilitative impact of OOHC services through widespread dissemination of a broadened paradigm for recovery in OOHC.

PI_NAMEs: SELLERS, DEBORAH E (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: Address;Adolescence;Adult;Affect;anxiety states;Behavior;Caregivers;caregiving;caregiving outcomes;Caring;Child;Child Care;child services;Chronic;Country;Critical Pathways;defense response;deprivation;Development;early childhood;Education;Educational workshop;Emotions;Environment;Ethnography;Evaluation;experience;farmer;Fostering;Foundations;Frequencies;Fright;Future;Goals;healing;Hour;Impairment;improved;Individual;Interview;Lead;long-term sequelae;Methods;Modeling;novel strategies;patient home care;Pattern;Play;Prevalence;prevent;Process;Program Development;programs;Provider;Recovery;Regulation;Rehabilitation therapy;Residential Treatment;response;Role;routine care;Safety;Series;Service setting;Services;Shapes;Signal Transduction;skills;social;social engagement;social reciprocity;success;Surveys;System;Testing;Therapeutic;Time;Training Programs;Trauma;Trust;United States Dept. of Health and Human Services;Universities;uptake;Work

PROJECT_TITLE: Enriching Relational Environments as a Critical Pathway for Healing from Trauma:  Helping Adults Use Purposeful Interactions and Build Developmental Relationships with Children in Out of Home Care

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Tobacco

ORG_DEPT: SURGERY

PHR: PROJECT NARRATIVE Cardiovascular diseases, which arise from a complex interplay between genetic predisposition and environmental influences, remain the leading cause of global death. The current proposal aims to take advantage of the human induced pluripotent cell-derived endothelial cell platform to establish a model system to stratify the patient risk of genetic variants in nicotine receptors for smoking-induced vascular diseases, and to study the potential mechanisms, with the ultimate goal to discover biomarkers for diagnosis and precise treatments for cardiovascular diseases and risks.

PI_NAMEs: GUO, HONGCHAO  (contact)

PROGRAM_OFFICER_NAME: GALIS, ZORINA S

PROJECT_TERMS: Advisory Committees;aerosolized;Agonist;Anti-Inflammatory Agents;Antiinflammatory Effect;Apoptosis;Asthma;Atherosclerosis;Bioinformatics;Biological Assay;Biological Markers;Biological Models;Biology;Biometry;Blood Vessels;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;career;career development;Career Mobility;CASP1 gene;Cell Adhesion;Cell Line;Cell model;Cell Survival;Cellular biology;Cessation of life;Clinic;Committee Members;Complex;CRISPR interference;CRISPR/Cas technology;cytokine;Development;Diagnosis;disease model;drug discovery;Drug Screening;Endothelial Cells;Environment;Environmental Health;Environmental Risk Factor;Exhibits;extracellular;Female;Functional disorder;Genetic;Genetic Predisposition to Disease;Genetic Risk;genetic variant;Goals;Grant;Health;High-Throughput RNA Sequencing;Human;human induced pluripotent stem cells;Hypersensitivity;IL18 gene;Immune System Diseases;Immunology;Individual;induced pluripotent stem cell;Induction of Apoptosis;Inflammation;inflammatory modulation;inhibitor;insight;Interleukin-1 beta;Knowledge;male;Mediating;meetings;Mentors;Mentorship;Modification;Molecular;Molecular Analysis;Nicotine;Nicotine Dependence;nicotine exposure;Nicotinic Receptors;novel;Pathway interactions;patient derived induced pluripotent stem cells;patient stratification;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;pollutant;Population;Positioning Attribute;Predisposition;prevent;Program Development;programs;protective effect;Reactive Oxygen Species;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Risk;risk variant;Role;screening;Signal Pathway;small molecule;Smoke;Smoking;stem cells;Stress;Structure;Study models;Techniques;Technology;Testing;Tobacco;Tobacco smoke;Training;transcriptome;transcriptome sequencing;Tubular formation;United States;Universities;Variant;Vascular Diseases;Work

PROJECT_TITLE: Delineating the Genetic Susceptibility of Smoking-Induced Vascular Dysfunction

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TALLAHASSEE

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Change in personality and behavior is one of the clinical criteria for the diagnosis of dementia. To further understand the evolution of Alzheimer’s disease and related dementias, the proposed work aims to better define the timing and trajectory of personality change with the onset of mild cognitive impairment and the transition to dementia. Further, the proposed research on the behavioral and biological processes that lead to dementia among individuals with a vulnerable personality profile will contribute to the development of tailored interventions to increase resilience against cognitive decline and risk of dementia.

PI_NAMEs: TERRACCIANO, ANTONIO  (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Acceleration;Address;Affect;Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid beta-Protein;Autopsy;Baltimore;Behavior;Behavior assessment;behavior prediction;Behavioral;Biological;Biological Markers;Biological Process;Brain;Brain Pathology;Brain region;Buffers;Cardiovascular system;Caregivers;Clinical;Cognition;Cognitive;cognitive change;cognitive reserve;comparative;Complex;coping;Data;Dementia;dementia risk;depressive symptoms;Development;Diagnosis;Dimensions;Disabling;Disease;Disease Progression;Education;effective intervention;Emotional;Etiology;Evolution;follow-up;Genetic;Genetic Predisposition to Disease;Genetic Risk;Goals;Health;human old age (65+);Hydrocortisone;Impaired cognition;Impairment;in vivo;Individual;Inflammation;innovation;Intervention;Lead;life span;Life Style;Loneliness;Longitudinal Studies;Magnetic Resonance Imaging;Maps;Measures;Mediating;Mediator;mild cognitive impairment;Modeling;Neurobiology;neuropathology;Neurotic Disorders;older adult;Outcome;Pathway interactions;Personality;Personality Assessment;Personality Traits;Persons;Phase;Physical Function;physical inactivity;Physiological;progression risk;promote resilience;prospective;Prospective Studies;protective effect;Psychological Factors;Psychopathology;psychosocial;Public Health;Research;resilience;Retrospective Studies;Risk;Risk Factors;Running;Smoking;Testing;Time;trait;white matter;Work;β-amyloid burden

PROJECT_TITLE: Personality and Dementia: Mechanisms and Trajectories


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CHICAGO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Increasingly, organelles are been found to signal to each other via intimate contacts. This new mode of signaling, whereby information is transferred without the organelles fusing, has wide-ranging impacts on health and disease. I propose to create an electrochemical atlas of organelles, apply it to study aberrant inter-organelle contacts in neurodegenerative disease and thereby identify common pathways one can target to restore contacts.

PI_NAMEs: KRISHNAN, YAMUNA  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Apoptosis;Atlases;Biological Assay;Cell Physiology;Characteristics;Chemicals;Communication;Cues;Cytoplasm;Development;Disease;Electrophysiology (science);Endoplasmic Reticulum;Equation;Face;Health;Hodgkin Disease;Homeostasis;Ion Transport;Ions;lipid metabolism;Lysosomes;Maps;Membrane;Modeling;Molecular;Mutation;Neurodegenerative Disorders;Neurons;Organelles;Parkinsonian Disorders;Pathway interactions;Physiology;prevent;Process;protein protein interaction;Proteins;seal;Signal Transduction;small molecule;Synapses;targeted treatment;Tissues;voltage

PROJECT_TITLE: Intracellular Electrophysiology: An electrochemical atlas of organelles


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Diabetes;Genetics;Heart Disease;Infant Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Pregestational diabetes is the number one non-genetic factor in inducing human congenital heart defects; however, the epigenetic mechanism and memories in the offspring hearts and cardiomyocytes are still unknown. Revealing the role of hypoxia and hypoxia inducible factor 1 in maternal diabetes-induced DNA hypermethylation during embryonic heart development will guide the potential development of inhibitors to hypoxia and DNA methylation and hyperoxia in reducing CHDs in diabetic pregnancy.

PI_NAMEs: SHEN, WEI-BIN ;TURAN, SHIFA ;YANG, PEIXIN  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: Apoptosis;Binding;Cardiac;Cardiac Myocytes;cardiogenesis;Cell Proliferation;Cells;Cellular Stress;Complex;Congenital Abnormality;Congenital Heart Defects;Defect;Development;Diabetes Mellitus;diabetic;diabetic embryopathy;DNA;DNA Methylation;DNA methylation profiling;DNA Modification Methylases;DNMT3a;DNMT3B gene;Embryo;Embryonic Heart;epigenetic memory;Epigenetic Process;Exposure to;Fetal health;Frequencies;Functional disorder;Gene Expression;Genes;gestational hypoxia;glycemic control;HCN4 gene;Heart;heart defect;heart function;Human;human disease;Hyperglycemia;Hypermethylation;Hyperoxia;Hypertrophy;Hypoplastic Left Heart Syndrome;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Impairment;imprint;improved;Incidence;induced pluripotent stem cell;Inflammation;inhibitor;insight;maternal diabetes;Mus;Myocardial dysfunction;non-genetic;offspring;Pathway interactions;Patients;pluripotent stem cell differentiation;Pregnancy in Diabetics;prevent;progenitor;programs;promoter;Regulatory Element;Rodent Model;Role;Testing;Up-Regulation;Woman

PROJECT_TITLE: Heightened hypoxia and DNA methylation in heart defects of diabetic embryopathy

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Childhood Injury;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases;Regenerative Medicine;Stroke;Unintentional Childhood Injury

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE Stroke in the newborn period is a common cause of long-term neurodevelopmental dysfunction, with profound socioeconomic impact, and diagnosis is frequently delayed. The overall goals of this proposal are to better understand how the developing brain responds to early injury, and to identify novel therapeutic strategies to increase repair and improve outcomes even when treatment is delayed.

PI_NAMEs: GONZALEZ, FERNANDO FRANCISCO (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Acute;angiogenesis;Angiogenesis Inhibition;Area;Astrocytes;Behavioral;Blood Vessels;Brain;Brain Injuries;Brain region;Cause of Death;Cell Communication;Cell Therapy;cell type;Cells;Chronic;Cicatrix;conditional knockout;Critical Pathways;Data;Diagnosis;disability;Dose;Early treatment;economic impact;Endothelial Cells;Endothelium;Erythropoietin;Erythropoietin Receptor;Fibroblasts;Fibrosis;Focal Brain Injuries;Functional disorder;Functional impairment;functional outcomes;Gene Expression Profile;Genetic Transcription;Goals;Growth;Growth Factor;Heme;Histologic;Hypoxia;Immunophenotyping;improved;improved outcome;Infarction;Injury;Ischemia;ischemic injury;Knockout Mice;Knowledge;Measures;Mediating;mesenchymal stromal cell;Methodology;Middle Cerebral Artery Occlusion;Molecular;Mus;Natural regeneration;Neonatal;neonatal brain;Neonatal Brain Injury;neonatal stroke;neurovascular;Newborn Infant;notch protein;novel;novel therapeutic intervention;Outcome;Paracrine Communication;Pathway interactions;Pericytes;perinatal ischemic stroke;Phase;Population;post stroke;post-stroke angiogenesis;Pre-Clinical Model;programs;Proliferating;public health relevance;Publishing;Recovery;repaired;Reperfusion Injury;response;Role;Signal Pathway;Signal Transduction;socioeconomics;Stroke;Stromal Cells;Testing;Therapeutic;Time;trafficking;treatment strategy;Validation;Vascular Endothelial Growth Factors;Work

PROJECT_TITLE: Endothelial tip cell-mediated angiogenesis and repair after neonatal stroke

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE The plasticity and functional diversity of regulatory T cells (Tregs) is essential for the maintenance of healthy immunity but it is also exploited in disease. Our findings implicate β-catenin, TCF-1, and HEB in partnering with Foxp3 to independently regulate the diverse Treg suppressive activities which can be modulated during chronic inflammation. Our current findings support the hypothesis that Wnt/β-catenin signaling differentially regulates Treg suppressive functions and diversity, by controlling access of Foxp3 and HEB to select chromatin sites bound by Tcf-1 which we will address in this proposal.

PI_NAMEs: GOUNARI, FOTINI  (contact);KHAZAIE, KHASHAYARSHA

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Address;antagonist;Autoimmune;Autoimmunity;beta catenin;Binding;Binding Proteins;Binding Sites;Cell Physiology;cell type;Cells;Cellular biology;Characteristics;Chromatin;Chronic;chronic inflammatory disease;Colon;Colon Carcinoma;Colonic Neoplasms;Data;diagnostic development;Disease;dominant active;Drops;Enhancers;Epigenetic Process;Epithelial Cells;Eragrostis;Experimental Autoimmune Encephalomyelitis;Fostering;FOXP3 gene;Frequencies;G-Protein-Coupled Receptors;gastrointestinal epithelium;Gene Expression;gene repression;Genes;Genetic;Genetic Enhancer Element;Genetic Transcription;Health;Human;IL17 gene;Immunity;immunological intervention;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Interferon Type II;Interruption;Knowledge;Ligands;Link;Maintenance;Malignant Neoplasms;Mediating;mesenteric lymph node;Modeling;Molecular;multimodality;Multiple Sclerosis;murine colitis;Mus;novel diagnostics;novel therapeutics;Outcome;Pathology;Pathway interactions;Peripheral;polyposis;prevent;Property;Regulatory T-Lymphocyte;Repression;Role;Shapes;Signal Transduction;single-cell RNA sequencing;T-Cell Activation;T-Cell Development;T-Lymphocyte;Therapeutic;Tissues;tool;transcription factor;Transcription Repressor;Transforming Growth Factor beta;Wnt proteins;WNT Signaling Pathway;Work

PROJECT_TITLE: How beta-catenin expands Foxp3+RORgammat+ Pro-inflammatoryT-regulatory cells - Renewal

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease;Networking and Information Technology R&D (NITRD);Prevention;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Coronary artery bypass grafting (CABG) is a gold standard treatment for patients with advanced coronary artery disease, however saphenous vein graft (SVG) failure after CABG is a pressing clinical problem, with 40- 50% of SVGs failing within 5-10 years, and there are no clinically available proven treatments. We aim to develop growth and remodeling models of vein graft arterialization, informed and validated with animal and human data, culminating in a novel fluid solid growth model of vein graft disease progression that will be used to test a novel 3D printed device for prevention of graft failure. Our ultimate goal is to increase mechanistic understanding of SVG disease progression, develop a device to mitigate failure, and ultimately improve outcomes of CABG patients, for whom there are limited treatment options.

PI_NAMEs: HUMPHREY, JAY D.;MARSDEN, ALISON L (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;3D Print;Acceleration;animal data;Animals;Biocompatible Materials;Biological;Biology;Blood Vessels;Cardiovascular system;Caring;Carotid Arteries;Cells;Clinical;Computer Models;Computer software;Computing Methodologies;Coronary Arteriosclerosis;Coronary Artery Bypass;Coronary Vessels;Data;Data Set;design;Device Designs;Devices;Diffuse;Disease Progression;elastomeric;Elastomers;Estimation Techniques;experimental study;Failure;Funding Agency;Geometry;Goals;graft failure;Growth;hemodynamics;high risk population;Histology;Human;human data;human study;Image;improved outcome;in silico;In Vitro;in vivo;Inflammation;innovation;Joints;Liquid substance;manufacture;mechanical stimulus;Mechanics;Mediating;Medical;Medical Imaging;Methodology;Modeling;Morbidity - disease rate;mortality;multidisciplinary;novel;open source;Operative Surgical Procedures;Oryctolagus cuniculus;Parameter Estimation;Patients;Performance;Postoperative Period;Preclinical Testing;predictive modeling;prevent;Prevention;Process;Property;Publications;response;Saphenous Vein;Sheep;simulation;Solid;standard care;Stenosis;Stress;Structure;Structure of jugular vein;Techniques;Testing;Tissue Grafts;Tissues;transcriptome sequencing;translational approach;Uncertainty;Vein graft;Veins;Venous

PROJECT_TITLE: Computational model-driven design to mitigate vein graft failure after coronary artery bypass

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(02)M]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative While some patients with pancreatic cancer are living longer, additional approaches, including combinatorial therapies against new targets are needed. Therefore, we propose to investigate a validated therapeutic target, Redox factor-1 (Ref-1), alone and in combinations that selectively kill the tumor by impinging on critical pathways the tumor is using to survive. After advancing the first-generation Ref-1 inhibitor (APX3330) to a phase I clinical trial in adult patients, we have identified next generation Ref-1 inhibitors, a strategy to screen for patients that have sensitivity to Ref-1 inhibition, and molecular targets that are likely to synergize with Ref-1 inhibition.

PI_NAMEs: FISHEL, MELISSA L.;KELLEY, MARK R. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Adult;advanced disease;analog;Bioinformatics;cancer cell;candidate selection;carbonate dehydratase;Cell Line;Cell Proliferation;Cells;Characteristics;Citric Acid Cycle;Clinical;clinical development;Clinical Trials;Coculture Techniques;combinatorial;Combined Modality Therapy;Critical Pathways;Data;design;Development;Disease;disorder control;Dose;Drug Combinations;Drug resistance;Enzymes;Evaluation;Future;Gene Expression;Generations;Genes;Genetic Transcription;Growth;Hypoxia;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Investigational Drugs;knock-down;Lead;lead candidate;lead optimization;Malignant neoplasm of pancreas;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Mitochondria;Molecular Target;Mus;Neoplasm Metastasis;next generation;novel;novel therapeutics;nutrient deprivation;Organoids;Outcome;Oxidation-Reduction;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;patient derived xenograft model;patient screening;Patients;personalized approach;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Play;pre-clinical;preclinical development;programs;Proliferating;Reaction;Resistance;resistance mechanism;response;Role;Signal Transduction;Signaling Protein;Solid Neoplasm;spheroids;synergism;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Tissues;Toxic effect;transcription factor;Treatment Efficacy;Triage;trial design;tumor;tumor growth;tumor metabolism;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Antiretroviral pre-exposure prophylaxis is an important tool for HIV prevention, with recent trials assessing new drug combinations. The limitations of clinical trials will increasingly require novel quantitative methods to reliably evaluate new interventions. The proposed study will use data from randomized trials, as well as novel methods, to address challenges in evaluation of new pre-exposure prophylaxis combinations.

PI_NAMEs: ZIVICH, PAUL NICHOLAS (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acceleration;active comparator;Address;Adherence;Adoption;AIDS prevention;analytical tool;Anti-Retroviral Agents;arm;Award;career;cis-female;Clinical Trials;Communicable Diseases;Computer software;Data;data fusion;data integration;Development;Effectiveness;efficacy evaluation;Eligibility Determination;emtricitabine;epidemic response;Epidemiologic Methods;Epidemiology;Evaluation;flexibility;Formulation;Fumarates;Future;Goals;HIV;HIV Infections;HIV prevention trials network;improved;inclusion criteria;Injectable;interest;Intervention;Knowledge;Learning;men who have sex with men;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;Modeling;multiple data sources;novel;novel drug combination;open source;Oral;Participant;Pattern;Physicians;placebo controlled trial;Placebos;pre-exposure prophylaxis;Public Health;Randomized;randomized trial;recruit;Research;Research Methodology;Research Personnel;Sample Size;Scientist;semiparametric;side effect;Software Tools;Source;Tenofovir;theories;tool;Training;transgender women;treatment comparison;trial planning;Vagina

PROJECT_TITLE: Combining sources of information to improve HIV pre-exposure prophylaxis

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Neurosciences

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: PROJECT NARRATIVE  In this proposal, our interdisciplinary team brings together expertise and stakeholders from neuroscience basic and clinical research, cognitive and social psychology, and experimental methods education to develop a unique set of curricula focused on increasing rigor and transparency in biomedical research. Through modules that focus on the decision-making crossroads at various phases of the research process, we aim to address the root causes of the ‘Reproducibility Crisis’ and set the stage for the next frontier of neuroscience research.

PI_NAMEs: BRODY, SALENA ;KOLBER, BENEDICT J (contact);YBARRA, REGINA KAKHNOVETS

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Address;Adopted;Adoption;Animals;Area;Attention;Basic Science;Beauty;Biomedical Research;clinical practice;Clinical Research;Cognitive;Cognitive Science;curriculum development;Data;Data Collection;data management;Data Reporting;Decision Making;decision research;design;Development;digital;digital platform;Education;Educational Curriculum;Educational Models;Educational Status;Educational workshop;Electronics;equity, diversity, and inclusion;Error Sources;Evaluation;experience;Experimental Designs;experimental study;Foundations;frontier;Funding;graduate student;Grant;Growth;Guidelines;heuristics;Hospitals;Human;Humanities;improved;in vivo;Individual;Institution;interest;Intervention;Knowledge;Laboratories;Lead;Learning;Literature;Location;Measures;Methods;Modeling;Nature;Neurosciences;Neurosciences Research;Operating Rooms;Operative Surgical Procedures;Outcome;Participant;pedagogy;Phase;Philosophy;Postdoctoral Fellow;pressure;Procedures;Process;professor;Program Development;programs;psychologic;Psychology;Publications;remediation;Reporting;Reproducibility;Research;Research Personnel;Resources;Running;Safety;Scholarship;Science;Scientist;Seasons;Self-Examination;Social Psychology;Standardization;Surgeon;System;Texas;Time;Training;Training Activity;training opportunity;Trust;Uncertainty;undergraduate student;Universities;War;wasting;Work;World Health Organization

PROJECT_TITLE: Crossroads: Using decision making strategies to develop high impact content for training in rigor and transparency.


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Aging;Genetics;Hematology;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Our studies will define the role(s) of septin6 group proteins in murine and human hematopoiesis with a focus on the unique versus overlapping roles of Septin6, Septin8, and Septin11, specifically in hematopoietic cell migration and homing, differentiation, proliferation, and engraftment and correlate these phenotypes with cytokinesis, cell cycle, polarity, apoptosis and the aging phenotype. We will investigate the nature of the abnormal blood and marrow findings in humans with mutations of SEPTIN6 that we have recently described.

PI_NAMEs: WILLIAMS, DAVID A (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: Adopted;Affect;Aging;Amino Acid Sequence Homology;Amino Acid Substitution;Amino Acids;Apoptosis;Awareness;Blood;Bundling;C-terminal;CD34 gene;Cell Cycle;Cell Differentiation process;Cell division;cell motility;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Clinical;Codon Nucleotides;combinatorial;Complex;CSF3 gene;Cytokinesis;Data;Diffusion;Engraftment;Exocytosis;Exons;Filament;Genes;Germ Lines;Germ-Line Mutation;GTP Binding Domain;Guanosine Triphosphate Phosphohydrolases;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;Homing;Human;in silico;In Vitro;Individual;knock-down;Link;male;Mammalian Cell;Marrow;member;Microfilaments;Modeling;Mus;mutant;Mutation;Myelogenous;Myeloid Cells;Myeloid Progenitor Cells;N-terminal;Nature;Neutropenia;Newborn Infant;novel;Nucleotides;old mice;Pathologic;Pathway interactions;Patients;Phenocopy;Phenotype;Play;predictive modeling;Proliferating;Proline;Proteins;Publications;Refractory;Regulation;Reporting;Role;stem cell growth;Structure;Syndrome;Tetraploidy;trafficking;Variant;Vesicle;Xenograft Model

PROJECT_TITLE: The role of Septin6 Group in Murine and Human Hematopoiesis

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Genetics;Human Genome;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Glioblastoma Multiforme is the most common and deadliest cancer in the central nervous system. Our research seeks to take existing patient genomics information and translate that through biological modeling to understand the molecular mechanism of the disease and associated co-morbidities. Through our approach, we will identify patient specific pathways driving this disease, providing a much needed advance towards personalized medicine for this most deadly of diseases.

PI_NAMEs: YU, KWANHA  (contact)

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Address;Affect;Alleles;Automobile Driving;Bar Codes;Big Data;Biological Models;Biology;Central Nervous System;comorbidity;Diagnosis;Disease;Electroporation;Epilepsy;functional genomics;Genetic;genetic testing;genomic data;Genomics;Glioblastoma;Glioma;Gliomagenesis;improved;in utero;in vivo;Informatics;insight;Malignant Neoplasms;Methods;Modeling;Molecular;next generation sequencing;novel;novel therapeutics;Pathway interactions;patient prognosis;Patient-Focused Outcomes;Patients;personalized medicine;programs;Quality of life;Research;screening;Series;System;Technology;Testing;Therapeutic;tool;Translating;trend;Variant

PROJECT_TITLE: Functional Genomics of High Grade Glioma


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_DEPT: BIOCHEMISTRY

PHR: After an RNA is transcribed, it contains numerous regulatory elements within the RNA transcript that enable trans-interacting proteins and regulatory RNAs to regulate processing steps including splicing, RNA decay, and translation into protein. Although the development of genomics approaches has enabled the large-scale mapping of protein:RNA interaction sites, sifting through these thousands (or more) sites per protein to identify the small subset that correspond with functional regulation of RNA processing remains underexplored. In this work, we will perform large-scale assays to screen these interactions to generate true regulatory maps for RBPs and regulatory RNAs, building unique insights into the RNA processing landscape in humans.

PI_NAMEs: VAN NOSTRAND, ERIC LYMAN (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Affect;Antisense Oligonucleotides;Area;Binding Sites;Biological Assay;Biology;Catalogs;Cell Nucleus;Databases;Development;Disease;Elements;Foundations;Genetic Transcription;Genetic Variation;Genomic approach;genomic profiling;Genomics;Half-Life;Human;Human Genetics;improved;Individual;insight;interest;knock-down;Knowledge;Laboratory Finding;Location;Maps;Mediation;Methods;Pharmaceutical Preparations;Physiological;Proteins;Regulation;Regulatory Element;Reporter;Research;Research Personnel;Ribosomes;RNA;RNA Binding;RNA Decay;RNA Processing;RNA Splicing;RNA Stability;RNA-Binding Proteins;RNA-Protein Interaction;Site;Small Nuclear RNA;Small Nucleolar RNA;Spinal Muscular Atrophy;Techniques;tool;Transcript;Translations;Work

PROJECT_TITLE: Large-scale characterization of the function of RNA regulatory elements


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

PHR: Narrative Leveraging our previous HIV surveillance work with health departments, the goal of this study is to refine, based on community feedback, an mHealth app, WiseApp, to recruit, screen, enroll, and retain a large digital cohort of people with HIV (PWH) over age 18 years (N=1000) who have non-sustained viral suppression (nVS) or who have no evidence of HIV labs within the past 12 months. The study will be conducted in the Deep South, the area of the country with the highest rates of morbidity and mortality, including the states of Alabama, Louisiana, and Mississippi. The findings from this study will inform efforts to recruit large, digital cohorts of PWH, will be among the first to demonstrate effective methods of retaining digital cohorts for HIV as well as other health conditions, and help identify multilevel factors that contribute to nVS in the Deep South, thereby elucidating areas for intervention in future research.

PI_NAMEs: BATEY, DAVID S.;RANA, AADIA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: 18 year old;Address;Adherence;Age;Alabama;antiretroviral therapy;Area;Automobile Driving;Caring;Case Study;Censuses;Centers for Disease Control and Prevention (U.S.);Characteristics;cohort;Collaborations;Communities;community advisory board;community based participatory research;Continuity of Patient Care;cost;Country;Data;Data Collection;Data Reporting;Databases;Deep South;Dependence;Diagnosis;digital;Elements;Eligibility Determination;Enrollment;Epidemic;Epidemiology;epidemiology study;ethnic minority population;evidence base;Exclusion;experience;Feedback;follow-up;Foundations;Funding;Future;Geography;Goals;Health;Health behavior;health care availability;health management;Healthcare;Heterogeneity;HIV;HIV diagnosis;HIV/AIDS;improved;improved outcome;Incidence;Individual;Inequality;Inequity;Infection;Information Systems;Insurance;Intervention;Interview;Laws;lens;Link;Louisiana;Low income;Measures;Mediator;member;Methods;mHealth;mhealth interventions;Mississippi;Mobile Health Application;Modeling;Morbidity - disease rate;mortality;Newly Diagnosed;Outcome;Participant;Persons;Policies;population health;Poverty;primary outcome;prospective;prototype;psychosocial;Public Health;Qualitative Methods;racial minority;Racial Segregation;Rana;recruit;Reporting;Research;residence;Resources;response;Role;Sampling;Self Management;social;social service provider;social stigma;social structure;Standardization;structural determinants;surveillance data;Surveys;System;systems research;Technology;Testing;therapy adherence;therapy development;Time;transmission process;treatment services;trend;U-Series Cooperative Agreements;United States;usability;Viral;Viral Load result;Work

PROJECT_TITLE: Drive to Zero: Developing a digital cohort to understand the drivers of non-sustained viral suppression in the Deep South


ED_INST_TYPE: OVERALL MEDICAL

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: NARRATIVE The development of resistance to mutant KRAS inhibitors is currently a major obstacle for the treatment of KRAS mutant cancers and the underlying mechanisms are not well-understood. The proposed research is relevant to public health because it will reveal a newly-identified resistance mechanism to the KRAS-targeted therapy, and success of this proposal will not only expand our knowledge of KRAS signaling and biology but also shed light on novel therapeutic strategies against KRAS mutated cancer to achieve durable therapeutic response.

PI_NAMEs: YAO, WANTONG  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Address;antitumor effect;Area;Automobile Driving;Biochemical;Biological Models;Biology;Bypass;Cancer cell line;Cancer Model;cancer therapy;cancer type;Cell Culture Techniques;Cell membrane;Cell Survival;Clinical;Clinical Trials;Colon;Colon Carcinoma;Colorectal Cancer;Data;Dependence;Development;Disease remission;Disease Resistance;disorder control;DNA Sequence Alteration;effective therapy;Event;FDA approved;Genetic Transcription;Genetically Engineered Mouse;Goals;HDAC5 gene;Human;improved;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;innovation;knockout gene;Knowledge;KRAS oncogenesis;KRAS2 gene;Laboratories;Light;Lipid Binding;Lipids;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Membrane;Mission;Modeling;Molecular;Monoclonal Antibodies;mutant;Mutate;Mutation;National Cancer Institute;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Oncogenes;Oncogenic;pancreatic cancer model;pancreatic cell line;pancreatic ductal adenocarcinoma model;Pathway interactions;Patient-Focused Outcomes;Patients;Phase;pre-clinical;preclinical evaluation;prevent;programs;Public Health;recombinase;Recovery;Regulation;Research;Resistance;Resistance development;resistance mechanism;response;Role;Signal Transduction;success;Surface;targeted agent;targeted cancer therapy;targeted treatment;Testing;Therapeutic;Therapeutic antibodies;Therapeutic Effect;therapeutic target;therapy development;therapy resistant;trafficking;translatable strategy;translational potential;Transmembrane Domain;treatment response;tumor;Work

PROJECT_TITLE: Targeting Acquired Resistance in KRAS Driven Cancers

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Clinical Research;Hematology;Opioids;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

PHR: PROJECT NARRATIVE It is desirable to avoid detrimental drug interactions to ensure each patient achieves the best possible response to their chemotherapy. The goal of this research proposal is to determine the impact of opioid- chemotherapy interactions on chemotherapeutic efficacy in blood cancer.

PI_NAMEs: CONSTANCE, JONATHAN ERIC (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Absence of pain sensation;acute leukemia cell;Acute Lymphocytic Leukemia;Affect;Age Years;Animal Model;Apoptotic;B-Lymphocytes;Binding;biobank;cancer cell;cancer diagnosis;cancer therapy;cancer type;Cell Death;cell killing;Cell Line;Cell Separation;Cell Survival;cell type;Central Nervous System;Cessation of life;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Child;chronic myeloid leukemia cell;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;cytotoxic;Data;Diagnosis;Dimensions;Disease;Drug Interactions;Drug Kinetics;Drug resistance;early experience;Enrollment;Ensure;experience;Fentanyl;Flow Cytometry;Frequencies;Genes;genetic approach;genotoxicity;Glioblastoma;Goals;Hematopoietic Neoplasms;high throughput screening;Image;Immunophenotyping;In Vitro;insight;interpatient variability;K-562;Knock-out;leukemia;leukemia treatment;Leukemic Cell;Life;Link;Literature;Malignant Breast Neoplasm;Malignant neoplasm of esophagus;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mediating;Medical;Metabolic;Molecular;Molecular Target;Morphine;mu opioid receptors;Neoplasm Metastasis;Newly Diagnosed;Opioid;Opioid Analgesics;opioid exposure;opioid use;Outcome;Oxycodone;Pathway interactions;Patients;peripheral blood;personalized medicine;Pharmaceutical Preparations;pharmacologic;Philadelphia Chromosome Positive Chronic Myelogenous Leukemia;Physiological;Plasma;Population;precision medicine;prescription opioid;Proliferating;prospective;Public Health;Recurrent disease;Relapse;Research Proposals;Resistance;response;Risk;Role;Sampling;Signal Pathway;Signal Transduction;standard of care;Study models;Supportive care;synergism;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Treatment Efficacy;Treatment Failure;treatment response;treatment risk;tumor growth;Tyrosine Kinase Inhibitor;United States National Institutes of Health

PROJECT_TITLE: Opioid-induced changes to chemotherapeutic activity in blood cancer


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: TUCSON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

PHR: NARRATIVE Cardiovascular disease remains an enormous health burden in the United States. Abnormal Ca2+ release in the diseased heart is closely coupled to increased oxidative stress, yet clinical trials aimed to reduce this stress have largely failed to elicit any functional benefits on cardiac Ca2+ handling. This proposal will uncover new molecular mechanisms that link oxidative stress to the regulation of Ca2+ release, and provide insights into new therapeutic approaches to reduce Ca2+-dependent arrhythmias.

PI_NAMEs: HAMILTON, SHANNA  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Achievement;Address;Area;Arrhythmia;Automobile Driving;Award;Binding;Biochemical;Biosensor;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Physiology;career;Catecholaminergic Polymorphic Ventricular Tachycardia;Cell Line;Cells;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Complex;Coupled;Coupling;Cysteine;Cytosol;Data;design;Disease;Electron Transport;Environment;Enzyme Inhibition;Enzymes;experimental study;Foundations;Functional disorder;gain of function;Genes;Genetic;Goals;Health;Heart;Heart Diseases;Homeostasis;human induced pluripotent stem cells;human model;Hyperactivity;Hypertrophy;Image;Impairment;improved;In Situ;induced pluripotent stem cell derived cardiomyocytes;Inherited;insight;Laboratories;Link;Literature;loss of function;loss of function mutation;Maps;Mediating;Mentors;Modification;Molecular;Molecular Biology;Molecular Chaperones;molecular dynamics;Mus;Mutation;novel;novel therapeutic intervention;Ohio;Optics;oxidation;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;Oxygen;pharmacologic;Phase;Production;Protein Biochemistry;Protein Disulfide Isomerase;protein folding;protein protein interaction;Proteins;Rattus;Reactive Oxygen Species;receptor function;Regulation;Research;Rodent;Rodent Model;Role;Ryanodine Receptor Calcium Release Channel;RyR1;Sarcoplasmic Reticulum;sensor;Serine;Site-Directed Mutagenesis;skeletal;Source;stress reduction;Structure;sudden cardiac death;Sudden Death;Syndrome;System;Technology;Testing;Therapeutic;Thoracic aorta;Training;United States;Universities;Up-Regulation;Viral;Work

PROJECT_TITLE: Cardiac ryanodine receptor and oxidative stress


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: Heart disease is the leading cause of morbidity and mortality in the United States and mitochondrial dysfunction is a major contributor in disease progression. Better understanding of the pathological mechanisms underlying mitochondrial dysfunction during heart disease will improve preventive and therapeutic interventions. In this proposal, we will investigate the function and mechanism of a novel mitochondrial Ca2+ signaling regulatory factor, namely, family with sequence similarity 210 member A (FAM210A), which is required for maintaining mitochondrial homeostasis and cardiac health. These studies will lead to identification of novel therapeutic targets for treatment of mitochondrial cardiomyopathy and ischemic heart failure such as myocardial infarction among other mitochondrial disorders.

PI_NAMEs: YAO, PENG  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Adult;antiporter;Binding;Biochemical;biological adaptation to stress;blood pump;Cardiac;Cardiac health;Cardiac Myocytes;cardioprotection;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;conditional knockout;Coupled;Data;Disease Progression;EF Hand Motifs;Event;Exhibits;Family;Functional disorder;Genes;Heart;heart damage;Heart Diseases;Heart failure;heart function;Heterozygote;Homeostasis;Human;Hypertrophy;improved;In Vitro;in vivo;Infection;insight;Integral Membrane Protein;knock-down;Knockout Mice;Leucine Zippers;Mediating;member;Membrane Potentials;Mitochondria;mitochondrial cardiomyopathies;Mitochondrial Diseases;mitochondrial dysfunction;mitochondrial membrane;Mitochondrial Proteins;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myoblasts;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocardium;new therapeutic target;non-genetic;novel;Operative Surgical Procedures;overexpression;Oxidative Phosphorylation;Pathogenicity;Pathologic;Performance;Phenotype;Physiological;preventive intervention;protein expression;protein function;Reactive Oxygen Species;Regulation;respiratory;Ribosomes;Role;Signal Transduction;Stress;Testing;therapeutic development;Therapeutic Intervention;transcriptome sequencing;United States

PROJECT_TITLE: Deciphering the role of FAM210A in cardiac physiopathology

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ED_INST_TYPE: SCHOOLS OF OSTEOPATHIC MEDICINE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences;Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: BIDDEFORD

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: PROJECT NARRATIVE Fracture of the tibia and other osteoporotic fractures have a heavy societal burden with devastating consequences including morbidity and death. This project explores the role of saphenous nerve injury in controlling tibial bone mineral density through sensory nerves. A greater understanding of the impact of nerve injury on bone mass will aid in elucidating new risk factors predisposing individuals to tibial fracture.

PI_NAMEs: BECKER, KATHLEEN A (contact)

PROGRAM_OFFICER_NAME: KOVBASNJUK, OLGA NIKOLAEVNA

PROJECT_TERMS: Ablation;afferent nerve;Afferent Neurons;Anabolism;Architecture;bone;Bone Density;bone health;bone loss;bone mass;Bone remodeling;Bone Resorption;bone turnover;Calcitonin Gene-Related Peptide;Cell Count;Cells;Cessation of life;Chemicals;Communication;comparison control;cost;Data;Death Rate;Denervation;density;Dual-Energy X-Ray Absorptiometry;Female;Fiber;Fibula Fracture;Fracture;fracture risk;Genetic Transcription;Goals;Homeostasis;Individual;Injections;Injury;Lateral;Link;Methods;microCT;Morbidity - disease rate;mortality;Motor;Mus;Nerve;Nerve Fibers;nerve injury;nerve supply;nerve transection;Nervous System;Neurons;neurotransmission;Numbness;Operative Surgical Procedures;Osteoblasts;Osteoclasts;Osteogenesis;osteoporosis with pathological fracture;Pain;Periosteum;Peripheral Nerves;pharmacologic;Population;Predisposing Factor;prevent;Regulation;Reporter;Resiniferatoxin;Risk;Risk Factors;Role;Sensory;sensory input;sensory mechanism;Signal Pathway;Signal Transduction;Site;Source;Spinal Cord;Structure of tibial nerve;Surface;Testing;tibia;Tibial Fractures;transmission process;Tyrosine 3-Monooxygenase

PROJECT_TITLE: The Impact of Disrupting Sensory Innervation on Tibial Bone Mass


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Lung;Lung Cancer;Prevention

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The proposed project is consistent with the National Cancer Institute’s commitment to advancing behavioral health in cancer patients and to implementation science as a core research opportunity. The proposed project will combine these priority areas by developing interdisciplinary research infrastructure to support research on the dissemination and implementation of behavioral health interventions for older adults with cancer. The proposed Center for Implementation Research in Cancer in Later Life (CIRCL) will provide training and research support that will infuse dissemination and implementation research methods into new and existing projects across all stages of behavioral intervention development for older adults with cancer.

PI_NAMEs: CZAJA, SARA J;MCCONNELL, KELLY  (contact);REID, MANNEY CARRINGTON

PROGRAM_OFFICER_NAME: NORTON, WYNNE E

PROJECT_TERMS: Address;Adherence;Aging;Alcohols;Area;Award;behavior change;Behavior Therapy;Behavioral;behavioral health;behavioral health intervention;Behavioral Model;Benchmarking;cancer care;cancer diagnosis;Cancer Patient;cancer prevention;Cancer Survivor;cancer survivorship care;cancer therapy;Caregiver Burden;Caregivers;Caring;Clinic;clinical care;contingency management;cost effective;design;Development;Dissemination and Implementation;dissemination science;Distress;early-career faculty;Education;effective intervention;efficacious intervention;Ensure;Environment;Evaluation;evidence base;Fostering;health care service utilization;Healthcare;human old age (65+);implementation barriers;implementation research;implementation science;improved;Individual;Infrastructure;Infusion procedures;innovation;Institute of Medicine (U.S.);Institution;Interdisciplinary Study;Intervention;Intervention Studies;investigator training;Knowledge;late life;Leadership;Libraries;Malignant Neoplasms;Mental Health;Mentors;Mentorship;Methods;Mission;National Cancer Institute;Needs Assessment;older adult;Older Population;Outcome;outreach;Patient Care;Patient-Focused Outcomes;Phase;Physical activity;physical conditioning;physical symptom;Policies;Population;Population Heterogeneity;Preparation;Problem Solving;Procedures;programs;Quality of life;Recovery;Research;Research Activity;Research Infrastructure;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resources;sedentary lifestyle;Series;Social Environment;Structure;Students;symposium;System;Technology;telehealth;therapy development;Tobacco use;Training;Training Programs;Training Support;treatment adherence;Underrepresented Populations;United States National Institutes of Health;Update;web site;webinar

PROJECT_TITLE: Reducing the chasm in behavioral health care for older adults with cancer: Development of the Center for Implementation Research in Cancer in Later Life (CIRCL)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Precision Medicine

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Narrative This proposal seeks to field test a conversation aid designed to support shared decision-making and patient centered care for thyroid cancer diagnosis. An updated conversation aid will be used on a pilot randomized trial to assess the feasibility of a larger study evaluating the effects of it’s use on thyroid cancer diagnosis.

PI_NAMEs: SINGH OSPINA, NAYKKY  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: Address;Adult;Affect;anxious;Bankruptcy;Biopsy;cancer care;cancer diagnosis;cancer risk;care costs;career development;Caring;Clinic;Clinical;clinical practice;Clinical Trials;Clinical Trials Design;Collaborations;Communication;Complex;Control Groups;Counseling;Decision Making;design;Diagnosis;Diagnostic;Economic Burden;efficacy evaluation;efficacy trial;Electronics;Emotional;Enrollment;Epidemic;Evaluation;experience;Feedback;field study;Florida;Future;Goals;group intervention;Guidelines;imaging detection;implementation barriers;implementation science;improved;Incidence;Incidental Discoveries;individual patient;Indolent;interest;International;Interview;Investigation;K-Series Research Career Programs;Left;Life;Malignant neoplasm of thyroid;Malignant Neoplasms;Medical;men;Mentors;Multicenter Trials;multidisciplinary;National Cancer Institute;Nodule;novel;Oncology;overtreatment;Participant;Patient Care;patient engagement;patient oriented;Patient Preferences;Patient Selection;Patient-Centered Care;patient-level barriers;Patients;Persons;Practice Guidelines;Principal Investigator;Process;Prognosis;prototype;Qualitative Research;Quality of life;Randomized;randomized trial;Recommendation;Research;Research Methodology;Research Personnel;Risk;Scientist;shared decision making;Structure;System;Thyroid Gland;Thyroid Nodule;ultrasound;United States;Universities;Update;Visit;Woman;Work

PROJECT_TITLE: Adequate selection of patients for thyroid biopsy: evaluation of a shared decision making conversation aid

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: The proposed research is relevant to public health because it represents a new and alternative strategy to the urgent threat of infections by opportunistic fungal pathogens like the Candida spp. By focusing on how the stress response regulatory networks in the commensal yeast diverged from related non- commensal relatives, this research will generate novel, foundational knowledge on the adaptive strategies and potential weaknesses of the opportunistic pathogens, which will enable the future identification of novel antifungal strategies. Thus, the proposed research is relevant to the NIGMS core mission of supporting basic research to increase our understanding of biological processes and reduce illness.

PI_NAMEs: HE, BIN Z (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: anti-fungal agents;base;Basic Science;biological adaptation to stress;Biological Assay;Biological Process;Biophysics;Candida;Candida glabrata;Chromatin;combinatorial;Coupled;Dependence;Development;Evolution;fitness;Future;gene regulatory network;Genes;Genetic;genome-wide;Goals;innovation;inorganic phosphate;Knowledge;Mission;Modeling;National Institute of General Medical Sciences;novel;Opportunistic Infections;opportunistic pathogen;Oxidative Stress;pathogen;pathogenic fungus;Phenotype;Process;Public Health;Research;Resistance;response;Saccharomyces cerevisiae;Starvation;Stress;transcription factor;transcriptomic profiling;Virulence;Vision;Yeasts

PROJECT_TITLE: Evolution of Stress Response Gene Regulatory Network in a Commensal and Opportunistic Yeast Pathogen

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Estrogen;Infertility;Mental Health;Neurosciences;Social Determinants of Health;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative High levels of androgens in women is associated with disrupted neuroendocrine function and infertility, whereas low androgens decrease sexual behavior and fertility, and induce fatigue, depression, and bone loss in both sexes. High density of androgen receptors is observed in the brain, but their function in specific neuronal populations is unknown. We will use genetic mouse models and molecular tools to determine the role of androgens receptor in chemically defined subsets of neurons and the underlying mechanisms associated with reproductive deficits caused by altered androgens signaling in the brain.

PI_NAMEs: ELIAS, CAROL FUZETI (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Acceleration;Accessory Olfactory Bulbs;Aggressive behavior;Amygdaloid structure;Androgen Receptor;Androgens;Anxiety;Appearance;Aromatase;Athletic;Behavior;behavioral response;Bilateral;Binding;bone loss;Brain;Cardiovascular Diseases;Cell Nucleus;Chemicals;Collection;Complete Androgen-Insensitivity Syndrome;Cre-LoxP;Cues;Decreased Libido;density;designer receptors exclusively activated by designer drugs;Disease;Estradiol;Estrogens;Estrous Cycle;experience;Experimental Models;experimental study;Fatigue;Feedback;Female;Fertility;Functional disorder;Gender;gender affirming hormone therapy;gender dysphoria;Genes;Genetic;GNRH1 gene;Goals;Gonadal Steroid Hormones;Gonadotropins;Health;Human;human model;Hyperandrogenism;Hypothalamic structure;Individual;Infertility;Knock-out;Lesion;Libido;male;Maps;Mediating;Mental Depression;Modeling;Molecular;Morphology;mouse genetics;mouse model;Mus;mutant;nerve supply;neural circuit;neuroimaging;Neurologic;neuromechanism;neuronal circuitry;Neurons;Neurosecretory Systems;neurotransmission;Odors;Paraphilias;Partner in relationship;Pathway interactions;Performance;physical conditioning;Play;Polycystic Ovary Syndrome;Population;Prevention;receptor;Regulation;reproductive;reproductive axis;Reproductive Physiology;reproductive senescence;response;Role;sex;Sex Behavior;Sex Discrimination;Sexual Arousal;Sexual Health;Shapes;Signal Transduction;Site;Steroids;subfertility;System;Technology;Territoriality;Testing;Testosterone;Tetanus Toxin;tool;Uterus;Viral Vector;virtual;Woman

PROJECT_TITLE: Sex-specific role of androgen signaling in neuroendocrine-behavior interface

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative To assemble and sustain functional tissues, cells need to establish and maintain an asymmetric organization of their membrane and cellular contents, a phenomenon referred to as cell polarity. Polarity must be coordinated between cells and controlled by extracellular signals in order for cells to behave normally; loss of this coordination is associated with developmental defects, early embryonic lethality and metastatic cancer. This proposal makes use of innovative experimental methods to study how cells polarize and how polarity is controlled during development, which is relevant to the NIGMS mission because it will increase understanding of a basic biological process and lay the foundation for advances in disease diagnosis, treatment and prevention.

PI_NAMEs: DICKINSON, DANIEL J (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Age;age related;Animals;Anterior;Apical;Biochemical;Biochemistry;Biological Models;Biological Process;Caenorhabditis elegans;cell behavior;Cell Cycle;Cell Polarity;Cell Separation;cell type;Cells;Characteristics;Complex;Cues;Data;Defect;Development;Disease;disease diagnosis;Disseminated Malignant Neoplasm;Embryo;Eukaryotic Cell;experimental study;extracellular;Foundations;Genetic;Goals;Homeostasis;In Vitro;in vivo;in vivo Model;Individual;innovation;Knowledge;Learning;Link;Malignant Neoplasms;Maps;Measurement;Membrane;Methods;Microscopy;Mission;Molecular;Mutagenesis;National Institute of General Medical Sciences;novel;Outcome;Phosphotransferases;Play;polarized cell;Positioning Attribute;prevent;Prevention;programs;protein complex;Protein Dynamics;Protein Kinase;protein protein interaction;Proteins;Regulation;Reproducibility;Research;response;Role;Signal Pathway;Signal Transduction;single molecule;Somatic Cell;Specific qualifier value;sperm cell;Stereotyping;System;Testing;Tissues;tool;Work;zygote

PROJECT_TITLE: Understanding developmental control of cell polarity using single-cell in vivo biochemistry

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Firearms Research;Health Services;Mental Health;Patient Safety;Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Program Director/Principal Investigator (Last, First, Middle): Beidas, Rinad Sary PROJECT NARRATIVE Reducing access to firearms is a key strategy for suicide prevention in youth, yet many young people live in homes with firearms that are not safely secured. The proposed work has the potential to radically impact public health by testing which strategies are most effective in helping pediatric primary care clinicians to deliver an evidence-based firearm safety promotion program in pediatric primary care as a universal suicide prevention strategy. This clinical trial will take place in two large health systems in Michigan and Colorado and will use principles from behavioral economics to support clinician behavior change while also gathering information about effectiveness, acceptability, and costs, in order to inform large-scale program implementation efforts within the Mental Health Research Network and nationally to save the lives of American youth. PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

PI_NAMEs: BEIDAS, RINAD SARY (contact)

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: Academy;acceptability and feasibility;Accidents;American;Attitude;Behavior;behavior change;behavioral economics;Cessation of life;Childhood;Climate;Clinic;Clinical;clinical practice;Clinical Trials;cluster randomized design;Colorado;comparative effectiveness trial;Consolidated Framework for Implementation Research;Control Groups;cost;Counseling;design;Effectiveness;effectiveness evaluation;effectiveness trial;effectiveness/implementation trial;Electronic Health Record;evidence base;Evidence based practice;experience;Exposure to;extrinsic motivation;Family;Feedback;firearm access;firearm storage;Firearms;follow-up;Funding;Future;future implementation;Goals;group intervention;Gun injury;Guns;Health system;Healthcare;Home;Hybrids;implementation barriers;implementation efforts;implementation evaluation;implementation outcomes;implementation research;implementation strategy;implementation/effectiveness;improved;information gathering;insight;Intervention;Interview;intrinsic motivation;Knowledge;Leadership;Medicine;Mental Health;Methods;Michigan;mortality;Names;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Patients;Pediatrics;Persons;pragmatic trial;prevent;Prevention strategy;Primary Care;primary care clinician;primary care setting;primary care visit;primary outcome;Principal Investigator;programs;provider behavior;Public Health;Randomized;Recommendation;Reporting;Research;Role;Safety;safety and feasibility;safety testing;screening;secondary outcome;Secure;simulation;Suggestion;suicidal morbidity;suicidal risk;Suicide;Suicide attempt;Suicide prevention;System;Testing;Time;Training;United States;universal prevention;Visit;Work;Youth

PROJECT_TITLE: A Comparative Effectiveness Trial of Strategies to Implement Firearm Safety Promotion as a Universal Suicide Prevention Strategy in Pediatric Primary Care

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Eating Disorders;Mental Health;Mental Illness;Nutrition;Obesity

ORG_CITY: Minneapolis

ORG_NAME: HABITAWARE, INC.

PHR: Narrative Binge-eating behavior is a central feature of eating disorders (e.g., binge-eating disorder, bulimia nervosa, anorexia nervosa-binge-eating/purging subtype) and is associated with higher rates of psychopathology, psychosocial impairment, medical comorbidity, and more severe obesity, all of which pose significant public health problems. Passive detection of binge eating episodes combined with a context-based reminder intervention could assist a patient in resuming healthy eating patterns. We propose developing and testing a smartwatch app that identifies binge eating behavior and provides CBT strategies to the patient after the episode.

PI_NAMEs: KUMAR, SAMEER  (contact);PETERSON, CAROL B.

PROGRAM_OFFICER_NAME: SWEENEY, MARY MARGARET

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Adult;Agreement;Algorithms;anorexia nervosa binge-purge subtype;assessment application;Behavior;Binge Eating;Binge eating disorder;Bulimia;Characteristics;Cognitive Therapy;comorbidity;Consultations;Consumption;Data;data sharing;design;Detection;detection platform;Devices;Diagnostic;dietary restriction;Eating;Eating Behavior;Eating Disorders;Ecological momentary assessment;efficacy study;Evidence based intervention;experience;feasibility testing;Feedback;feeding;Focus Groups;Food;Goals;Hand;Healthy Eating;Hour;Impairment;improved;Individual;innovation;Intervention;Label;Location;machine learning algorithm;machine learning model;Maintenance;Medical;Modeling;Morbid Obesity;motion sensor;Motivation;Movement;National Institute of Mental Health;novel;novel strategies;Obesity;Outcome;Participant;patient engagement;Patient Self-Report;Patients;Pattern;Persons;Phase;pilot trial;Process;Protocols documentation;Psychopathology;psychosocial;Public Health;Randomized, Controlled Trials;Relapse;Reporting;Respondent;restrictive eating;Running;Schedule;Self Administration;sensor;smart watch;Stimulus;Strategic Planning;success;Surface;Surveys;System;Systems Development;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Time;tool;Training;Treatment Effectiveness;Treatment outcome;treatment strategy;usability;Validation;Video Recording;week trial;Wrist

PROJECT_TITLE: Technology Assisted Treatment for Binge Eating Behavior


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: IRVINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: How the body processes O2 is central to human health with metalloproteins being essential for maintaining proper regulation. Thus, the function, and dysfunction of key health related processes can be understood within the context of protein active site structures. These issues are being investigated with an integrative approach that leverages the power of synthetic chemistry with protein science/molecular biology to develop artificial metalloproteins as a means to establish key structure-function relationships that are inherent for superior processing of O2.

PI_NAMEs: BOROVIK, ANDREW S. (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Confining Metal Complexes within Protein Hosts: Models for Metalloprotein Active Sites

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: NOVATO

ORG_NAME: BUCK INSTITUTE FOR RESEARCH ON AGING

PHR: OVERALL TMC - PROJECT NARRATIVE  Many stressors, including aging, can cause cells can enter a state termed senescence. Senescent cells are likely important drivers of many age-related pathologies, from neurodegeneration to cancer, but are poorly characterized. Within the SenNet Consortium, we will establish a Tissue Mapping Center to characterize senescent cells -- molecularly, spatially and during aging -- in three very different human tissues: ovary, breast and skeletal muscle.

PI_NAMEs: MELOV, SIMON ;SCHILLING, BIRGIT  (contact)

PROGRAM_OFFICER_NAME: OROSZ, ANDRAS

PROJECT_TERMS: Advanced Development;Affect;Age;age related changes;Age related pathologies;Aging;Atlases;biobank;Biocompatible Materials;Biologic Characteristic;Biological;Biological Markers;Biomedical Research;Breast;Budgets;Cell Aging;Cell Proliferation;cell type;Cells;Characteristics;chemokine;Collaborations;Communities;Complement;Complex;cytokine;Data;Data Analyses;Data Coordinating Center;data sharing;design;Development;Distal;Epithelium;experience;Feedback;Follicular Fluid;Gene Expression Profile;Genetic;Goals;Growth Factor;Head;Health;Human;human tissue;improved;Individual;Institution;interest;Laboratories;Lipids;Malignant Neoplasms;Maps;Mass Spectrum Analysis;method development;Molecular;Molecular Analysis;Mus;Nerve Degeneration;new technology;Organism;Output;Ovary;Participant;Pathologic Processes;Peptide Hydrolases;pharmacologic;Phenotype;Physiological Processes;Physiology;Plasma;Play;Principal Investigator;Process;Proteome;Proteomics;Protocols documentation;reproductive;Research;Research Personnel;Resource Sharing;Resources;response;Role;Sampling;Scientist;senescence;senescence associated secretory phenotype;senescent cell;single cell technology;Skeletal Muscle;Specimen;stressor;Structure;Techniques;Technology;technology development;tissue mapping;Tissues;transcriptome;transcriptomics;Urine;Validation;web site

PROJECT_TITLE: Senescent cell mapping, identification and validation for human somatic and reproductive tissues

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(70)R]