NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Human Genome;Liver Disease;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PI_NAMEs: SCHWANDT, MELANIE  (contact)

PROJECT_TERMS: addiction;Adult;adverse childhood events;Aggressive behavior;Albumins;Alcohol abuse;alcohol abuse therapy;alcohol behavior;alcohol comorbidity;Alcohol consumption;alcohol cue;Alcohol dependence;alcohol misuse;alcohol rehabilitation;alcohol response;alcohol risk;alcohol seeking behavior;alcohol sensitivity;alcohol use disorder;Alcohol withdrawal syndrome;Alcoholic Hepatitis;Alcoholism;Alcohols;Annual Reports;anxiety symptoms;Archives;Back;Behavior;behavior measurement;behavioral health;binge drinking;biobehavior;Biochemical;Biological Markers;Body mass index;Boston;Brain;Buffers;cardiometabolism;Cardiovascular system;Characteristics;Chronic stress;Cirrhosis;Clinic;Clinical;clinical care;clinical pain;Clinical Research;Collaborations;Collection;comorbidity;Consumption;craving;Data;Data Analyses;data sharing;data submission;Database Management Systems;Databases;Deposition;depressive symptoms;Diagnosis;Dimensions;Disease;disorder control;DNA Methylation;drinking;drinking behavior;early life stress;Electrocardiogram;Eligibility Determination;Emotional;Ensure;Environment;epidemiology study;ethnic disparity;Ethnic Origin;Etiology;Evaluation;Event;exome sequencing;Facial Expression;Fibrosis;follow-up;Food;Foundations;Future;Gender;Genes;Genetic;Genetic Predisposition to Disease;genetic variant;Genetic Variation;Genome;genome wide association study;genomic data;Genomics;Genotype;Goals;Hepatology;Heterogeneity;Human;human data;hypothalamic-pituitary-adrenal axis;Image;Immunoglobulins;Impairment;Impulsivity;Indiana;Individual;Individual Differences;Inflammation;inpatient service;Inpatients;Investigation;Ions;iron metabolism;Laboratories;Laboratory Research;Life;Link;Liver;Lupus;Machine Learning;Major Depressive Disorder;Manuscripts;Measurement;Measures;medical schools;Mental Depression;Mental Health;Metabolic;Metals;methylation pattern;Micronutrients;Modeling;Monitor;National Institute of Drug Abuse;National Institute on Alcohol Abuse and Alcoholism;Natural History;Neurobiology;neurogenetics;neuroimaging;Nicotine;Office Management;Oral health;Outcome;Outpatients;Pain;participant enrollment;participant retention;Patient Admission;Patients;Pattern;Pediatric Hospitals;pediatric trauma;Personal Satisfaction;Personality;phenome;Phenotype;phenotypic data;pleiotropism;polygenic risk score;polysubstance use;Population;Post-Traumatic Stress Disorders;posters;Preparation;Prevalence;prevent;problem drinker;programs;Protocols documentation;psychiatric comorbidity;Psychiatric Diagnosis;Psychopathology;Public Health;Publications;Publishing;quality assurance;Quality of life;Race;racial disparity;Receptor Gene;Recovery;Relapse;Reporting;repository;Research;Research Personnel;Research Project Grants;resilience;resilience scale;Resource Sharing;Resources;response;Rest;reward anticipation;Risk Factors;Role;Safety;Sampling;screening;Series;Severities;Sex Differences;sleep quality;Smoking;Smoking and Health Research;SNP genotyping;Social support;Standardization;Stress;stressor;Subgroup;Substance abuse problem;substance use;suicidal;Taste Buds;Therapeutic;timeline;Tissues;Trauma;trend;United States;United States National Institutes of Health;Universities;volunteer;Weight;Work

PROJECT_TITLE: NIAAA Repository/Screening Database Management and Research


ACTIVITY: ZIA

ADMINISTERING_IC: AA

ARRA_FUNDED: N

FUNDING_MECHANISM: INTRAMURAL RESEARCH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Neurosciences;Nutrition;Obesity;Opioid Misuse and Addiction;Opioids;Pain Research;Prescription Drug Misuse;Prevention;Substance Misuse

PI_NAMEs: JOSEPH, PAULE  (contact)

PROJECT_TERMS: addiction;Addictive Behavior;Animal Model;Behavior;Biological;Brain;Brain region;brain shape;Cessation of life;Chronic;Clinical;Collaborations;Consumption;Corpus striatum structure;Cues;design;Detection;Diet;diet-induced obesity;dietary;Dietary Intervention;differential expression;Discrimination;Disease;Eating Behavior;Electrophysiology (science);Energy Intake;Esthesia;Extramural Activities;Fatty acid glycerol esters;Food;Gene Expression;Genes;Genetic;Genomics;Goals;gut-brain axis;Health;hedonic;High Fat Diet;Immune;immune function;improved;Incidence;Inflammation;interest;International;Intervention;Journals;Mediator;Metabolic dysfunction;Metabolic Pathway;Metabolism;Methods;misuse of prescription only drugs;mitochondrial dysfunction;Molecular;Mus;Mutation;Neurobiology;neuronal circuitry;Neurons;Obese Mice;Obesity;olfactory bulb;Olfactory Cortex;opioid overdose;opioid use;opioid use disorder;optogenetics;Oxidative Stress;Pain;pain perception;Paper;Pathway interactions;pharmacologic;Phenotype;Physiological;pleasure;Population;preclinical study;prescription pain reliever;Property;Proteins;Protocols documentation;Publishing;Quality of life;Research;response;reward circuitry;Rewards;Role;Science;Sensory;sensory system;Smell Perception;Substance Use Disorder;sugar;Taste Perception;Taste preferences;Techniques;Testing;Tissues;transcriptome;transcriptome sequencing;transcriptomics;Translating

PROJECT_TITLE: Neurobiology of chemosensation, reward and eating behaviors; molecular and neuronal mechanisms along the gut-brain-axis in animal models


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cannabinoid Research;Endocannabinoid System Research;Lung;Orphan Drug;Pulmonary Fibrosis;Rare Diseases;Substance Misuse;Therapeutic Cannabinoid Research

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PI_NAMEs: CINAR, RESAT  (contact)

PROJECT_TERMS: Acute Lung Injury;Affect;Alcohol consumption;alcohol use disorder;Alcohols;Alveolar Macrophages;Animal Model;antagonist;antifibrotic treatment;Bleomycin;cannabinoid receptor antagonist;Cannabinoids;cell injury;Cells;Chemicals;Chronic;chronic alcohol ingestion;Chronic Disease;Clinical Medicine;CNR1 gene;Collaborations;Complex;Cre lox recombination system;Deposition;Development;Disease;Disease Progression;Drug Delivery Systems;Economic Burden;Endocannabinoids;Etiology;Extracellular Matrix;Fibroblasts;Fibrosis;Functional disorder;Goals;Hermanski-Pudlak Syndrome;Human;Hybrids;idiopathic pulmonary fibrosis;Immunity;improved;indium-bleomycin;Inflammation;Inflammatory;inhibitor;Injury;insight;interest;Interleukin-11;Knockout Mice;Liver;Lung;Lung Diseases;lung health;lung injury;Magnetic Resonance Imaging;male;Medical;Metabolic;Mitochondria;Modality;Modeling;Molecular;mortality;mouse model;multiple omics;Mus;Mutant Strains Mice;National Human Genome Research Institute;National Institute on Alcohol Abuse and Alcoholism;new therapeutic target;NOS2A gene;novel therapeutics;Organ;Outcome;Outcomes Research;Oxidative Stress;Pathogenicity;Pathologic;Pathologic Processes;Pathology;Pathway interactions;Patients;Peripheral;Pharmaceutical Chemistry;Pharmacology;Pharmacotherapy;Physiology;Pneumonia;problem drinker;Process;Publishing;Pulmonary Fibrosis;pulmonary function;rare genetic disorder;Recommendation;Research;Research Project Grants;Role;Route;Safety;Scientist;Scleroderma;Secondary to;sexual dimorphism;skin fibrosis;Study Section;System;Systems Biology;targeted treatment;Testing;Therapeutic;therapeutic candidate;therapeutic target;tissue injury;translational medicine;Treatment Efficacy;wound healing

PROJECT_TITLE: Fibroproliferative mechanisms in organ fibrosis


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cannabinoid Research;Diabetes;Endocannabinoid System Research;Neurosciences;Nutrition;Obesity;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: IYER, MALLIGA  (contact)

PROJECT_TERMS: Acute;Acute Lung Injury;Adenosine Monophosphate;Affect;Affinity;Agonist;Alcohol consumption;analog;antagonist;Anti-diabetic Drugs;Anti-Obesity Agents;Arachidonic Acids;Architecture;arm;Attenuated;Biguanides;Binding;Biochemical;Biological;Biological Assay;Biological Availability;Biological Process;Body Weight;Brain;brain dysfunction;cannabinoid receptor;CB1 receptor antagonist;Cell membrane;Cell Nucleus;Cells;chemical synthesis;Chronic Disease;Clinic;Clinical;CNR1 gene;CNR2 gene;Complex;Cytochrome P450;Derivation procedure;design;Development;Diabetic Nephropathy;diet-induced obesity;Disease;Drug or chemical Tissue Distribution;Drug Targeting;Eating;Eicosanoids;endogenous cannabinoid system;Enzymes;Epoxide hydrolase;Evaluation;Fatty acid glycerol esters;Fluorescence;G-Protein-Coupled Receptors;Generations;Glean;glucose tolerance;Goals;Half-Life;Human;human disease;improved;In Vitro;in vivo;Inflammatory;inflammatory marker;inhibitor;Insulin Resistance;insulin sensitivity;Intraperitoneal Injections;Investigation;Kinetics;Laboratories;lead candidate;lead optimization;Legal patent;Licensing;Ligands;Magnetic Resonance Imaging;Mediating;Metabolic;Metabolic syndrome;Metformin;Methodology;Methods;Modeling;Molecular;mouse model;Names;NOS2A gene;novel;novel therapeutics;Obese Mice;Obesity;Oral;Oral Administration;oxidation;Pain management;pain model;Pathway interactions;Penetrance;Penetration;Peripheral;personalized medicine;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;phase I trial;Phase II Clinical Trials;phase II trial;Phosphotransferases;Physiological;programs;Property;Pyrazoles;radioligand;reduced food intake;Reflex action;Reporting;Resolution;response;rimonabant;Rodent Model;Role;Safety;scaffold;sensor;Series;side effect;Signal Pathway;Specificity;Structure;Structure-Activity Relationship;Tail;targeted agent;Testing;tool;trafficking;Work

PROJECT_TITLE: Novel Cannabinoid Receptor Modulators


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Gene Therapy;Genetics;Hepatitis;Human Genome;Immunotherapy;Liver Cancer;Liver Disease;Rare Diseases;Regenerative Medicine;Substance Misuse

PI_NAMEs: GAO, BIN  (contact)

PROJECT_TERMS: Acetaldehyde;Actins;Acute;Adenosine;Adenoviruses;Affect;Aging;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcoholic Hepatitis;Alcoholic Liver Diseases;aldehyde dehydrogenases;angiogenesis;Angiogenesis Inhibition;Area;Attenuated;Automobile Driving;Bile fluid;Bioinformatics;capsule;Carbon Tetrachloride;Cell Death Induction;Cells;Chronic;chronic liver disease;Complement 1q;Data;Diethylnitrosamine;drinking behavior;Drug Metabolic Detoxication;Encapsulated;Environment;Ethanol;Ethanol Metabolism;Excision;Excretory function;fatty liver disease;Gastrointestinal tract structure;Gene Delivery;Genetic;Goals;gut-liver axis;Hepatic;Hepatic Stellate Cell;Hepatocarcinogenesis;Hepatocyte;Homologous Protein;Hypoxia;Hypoxia Inducible Factor;IL8 gene;Immune;Immunologics;Immunosuppression;implantation;In Vitro;in vivo;Infiltration;Inflammation;Inflammatory;Injections;Injury;Knockout Mice;Laboratories;Lesion;Liver;liver cancer model;liver cell proliferation;liver inflammation;liver injury;liver repair;Macrophage;Malignant Epithelial Cell;Malignant neoplasm of liver;Mediating;microRNA delivery;MicroRNAs;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myeloid Cells;Natural regeneration;Necrosis;Necrotic Lesion;necrotic tissue;neoplastic cell;neutrophil;new therapeutic target;notch protein;Organ;Pathogenesis;Pathway interactions;patient subsets;PD-1/PD-L1;Persons;Pharmacological Treatment;Play;Primary carcinoma of the liver cells;programmed cell death ligand 1;programmed cell death protein 1;recruit;Regimen;repaired;Resistance;Resolution;RNA analysis;Role;Serum;Signal Transduction;Site;Smooth Muscle;T-Lymphocyte;Therapeutic;transcription factor;transcriptome sequencing;tumor;tumor hypoxia;tumor microenvironment;Wild Type Mouse

PROJECT_TITLE: Pathogenesis and Novel Therapeutic Targets of Fatty Liver Disease and Cancer


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Cannabinoid Research;Cardiovascular;Digestive Diseases;Endocannabinoid System Research;Heart Disease;Kidney Disease;Liver Disease;Substance Misuse;Therapeutic Cannabinoid Research

PI_NAMEs: PACHER, PAL  (contact)

PROJECT_TERMS: 2-arachidonylglycerol;Acetaldehyde;Acquired Immunodeficiency Syndrome;acute liver injury;Acute Renal Failure with Renal Papillary Necrosis;Age;age related;age related biomarkers;Aging;Agonist;Alcohol consumption;alcohol use disorder;Alcohols;Animal Disease Models;Animal Experiments;Animal Model;Antibodies;antinociception;Attenuated;Behavior;Bile fluid;Biological Assay;Biological Availability;Blood;Brain;cardiometabolism;Cardiomyopathies;Cardiovascular Diseases;cardiovascular injury;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;Cell Death;Cells;Chronic;chronic alcohol ingestion;Clinical;clinical development;clinically relevant;CNR1 gene;CNR2 gene;Collaborations;Complex;Coupled;Development;digital;Disease;Dose;Drug Kinetics;endocannabinoid signaling;Endocannabinoids;endogenous cannabinoid system;Enzymes;Excretory function;Fibrosis;Functional disorder;Future;G-Protein-Coupled Receptors;Gastrointestinal tract structure;gut-liver axis;Heart;Heart failure;hepatoprotective;Human;humanized mouse;improved;In Vitro;industry partner;Inflammation;Inflammatory;Injury to Kidney;innovation;Institution;Ischemia;Kidney;Kidney Diseases;Laboratories;Left;Ligands;Lipids;Liver;Liver diseases;liver injury;MAGL inhibitor;Metabolic;Methods;minority patient;Modeling;Molecular;Monoacylglycerol Lipases;mouse model;Mus;Nature;neuroinflammation;new therapeutic target;nitrosative stress;non-alcoholic fatty liver disease;novel therapeutic intervention;Oral;Oxidative Stress;Pain;Pathology;Pathway interactions;Peripheral;Peripheral arterial disease;Pharmaceutical Preparations;pharmacologic;Play;Poly(ADP-ribose) Polymerases;Positioning Attribute;potential biomarker;Pre-Clinical Model;preclinical study;Property;Proprotein Convertases;Pyrazoles;Radiolabeled;Rattus;Reperfusion Injury;Reperfusion Therapy;Reporting;Research;Research Personnel;Role;screening;Serum;Signal Transduction;Source;Stress;Subtilisins;targeted biomarker;Therapeutic;therapeutic biomarker;therapeutic target;tissue injury;Tissues;Uncertainty;Universities;Ureteral obstruction;Validation;Ventricular;Work

PROJECT_TITLE: Mechanism of oxidative/nitrosative stress and inflammation-induced tissue injury


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Substance Misuse

PI_NAMEs: ANTOINE, MICHELLE  (contact)

PROJECT_TERMS: Achievement;adolescent with autism spectrum disorder;Adverse effects;Age;Amphetamines;Animal Care and Use Committees;Animal Model;Animals;Antipsychotic Agents;Area;aripiprazole;ASD patient;associated symptom;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavioral;Benign;Body Temperature;Brain;Brain region;Cells;Certification;Child;Clinical;Cocaine;Communication;COVID-19 pandemic;Development;Diagnostic;Disease;DNA Sequence Alteration;effective therapy;Exhibits;Exposure to;extreme heat;Fever;Future;Genetic;genetic variant;Goals;Hyperactivity;improved;individuals with autism spectrum disorder;Infection;Innovative Therapy;insight;interest;Knowledge;Learning;Manuscripts;Mediating;Medicine;model of autism spectrum disorder;Modeling;neural circuit;Neurons;new therapeutic target;Normal Range;Patients;Pharmaceutical Preparations;pharmacologic;Predisposition;Process;Protocols documentation;reduce symptoms;repetitive behavior;Reporting;Research;response;Risperidone;Seizures;Symptoms;Temperature;United States Food and Drug Administration;voltage gated channel

PROJECT_TITLE: Deciphering the mechanisms mediating the dichotomous effects of fever on brain function and behavior


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Endocannabinoid System Research;Mental Health;Neurosciences;Sleep Research;Substance Misuse

PI_NAMEs: KESNER, ANDREW  (contact)

PROJECT_TERMS: Abstinence;Acetylcholine;Action Potentials;Affect;Animal Model;Animals;Annual Reports;Appetitive Behavior;Apple;Architecture;Area;Arousal;Automobile Driving;Behavior;Behavioral Model;Blood Pressure;Brain;brain circuitry;Brain region;Calcium;Cannabis;cannabis cessation;cannabis withdrawal;CNR1 gene;cognitive enhancement;cohort;Consumption;Control Groups;Cues;Custom;Data;designer receptors exclusively activated by designer drugs;Dopamine;Drops;Drug usage;Drug Withdrawal Symptoms;Electroencephalography;Electronic Nicotine Delivery Systems;Endocannabinoids;Exposure to;Fiber;Flavoring;flexibility;gamma-Aminobutyric Acid;Glutamates;Goals;High Prevalence;Homing;Illicit Drugs;in vivo;Individual;Inhalation;Injections;interest;Intraperitoneal Injections;Journals;Learning;Legal;maladaptive behavior;marijuana use;marijuana use disorder;marijuana user;Measures;Medial;Mediating;Methodology;Methods;Modeling;Morphologic artifacts;motivated behavior;Motivation;Mus;National Institute of Environmental Health Sciences;Nature;neural;neural circuit;neuromechanism;Neuromodulator;Neurons;Neurotransmitters;Nucleus Accumbens;Peer Review;Photometry;Plasma;pre-clinical;presynaptic neurons;Presynaptic Terminals;Procedures;Process;programs;Property;Proteins;Psychological reinforcement;Psychotropic Drugs;Publications;Publishing;Rattus;receptor;Records Controls;reduce symptoms;Reinforcement Schedule;Relapse;REM Sleep;Reporting;Research;Research Personnel;Resistance;response;Retrieval;reward circuitry;Rewards;Role;Route;Self Administration;sensor;Signal Transduction;Sleep;sleep behavior;Sleep disturbances;Specificity;Stimulus;substance misuse;substance use;Substance Use Disorder;synergism;System;Techniques;Tetrahydrocannabinol;THC concentration;timeline;Training;Transgenic Organisms;trend;vapor;vaporization;vigilance;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Understanding interactions between brain reward and sleep systems in driving maladaptive behaviors


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Lupus

PI_NAMEs: HASNI, SARFARAZ  (contact)

PROJECT_TERMS: Adult;Affect;Atherosclerosis;Autoimmune;Biological;Biological Markers;biomarker identification;Blood;Blood flow;Blood Vessels;candidate marker;Cardiovascular system;Caring;Clinical;Clinical Trials;comorbidity;Consultations;COVID-19;Data;Diagnosis;Disease;disease natural history;Drug Monitoring;Eligibility Determination;Endothelium;Enrollment;Genetic study;Glucocorticoids;Goals;healthy volunteer;Image;Immune system;Informed Consent;Laboratories;Laboratory Study;Longterm Follow-up;Lupus;Lupus Nephritis;Medical;Natural History;Observational Study;Organ;Outcome;Pathogenesis;Pathogenicity;patient subsets;Patients;pediatric patients;Physical Examination;Physicians;premature atherosclerosis;Prognosis;Protocols documentation;Publications;Recommendation;Recording of previous events;Reporting;Research;research study;response;Risk;sample collection;Sampling;Severities;Skin;Specimen;systemic autoimmunity;systemic inflammatory response;Systemic Lupus Erythematosus;Testing;Therapeutic immunosuppression;Toxic effect;United States National Institutes of Health;Urine;Vaccines;Validation;Vascular Diseases;vascular inflammation;Viral

PROJECT_TITLE: Lupus Clinical Trials


ADMINISTERING_IC: CL

IC_NAME: CLINICAL CENTER

ORG_NAME: CLINICAL CENTER

PI_NAMEs: SUFFREDINI, ANTHONY F. (contact)

PROJECT_TERMS: Acinetobacter baumannii;Acute Lung Injury;Acute Respiratory Distress Syndrome;Allergic Bronchopulmonary Aspergillosis;Animal Model;Anti-Inflammatory Agents;Antibiotics;Aspergillus;Bacteria;Bacterial Infections;beta-Lactamase;Biological;Biological Markers;Biological Models;biomarker identification;Blood;Bronchoalveolar Lavage;Bronchoalveolar Lavage Fluid;Bronchoscopy;Burkholderia cepacia complex;candidate identification;candidate marker;canine model;carbapenemase;Cells;Censuses;Childhood;chymotrypsin;Clinical;clinical application;clinical center;clinical diagnosis;Clinical Microbiology;co-infection;colistin resistance;Collection;Communities;Complement;Culture-independent methods;Cytomegalovirus;Databases;Detection;Diagnosis;diagnostic biomarker;Diagnostic Procedure;Digestion;Elements;Engraftment;Enrollment;Enzymes;Etiology;Excision;expectation;Family;Gene Expression Profile;genomic data;Goals;Heart;High Pressure Liquid Chromatography;Immune response;Immunity;Immunoassay;improved;in vivo;Individual;Infection;Infiltration;Inflammation;Informed Consent;interest;Ions;Klebsiella pneumoniae;Label;Laboratories;Lavage;Leukocytes;Link;liquid chromatography mass spectrometry;Lung;Lung Diseases;Lung infections;lung pathogen;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Methods;microorganism;Modeling;Moraxella catarrhalis;multiplex assay;mycobacterial;Mycoses;novel diagnostics;novel strategies;opportunistic pathogen;Oryctolagus cuniculus;Outcome;pandemic disease;Parasitic infection;Participant;participant enrollment;pathogen;pathogenic fungus;pathogenic microbe;patient oriented;Patients;Pattern;Peptides;Pneumonia;pneumonia model;pre-pandemic;Process;Prognostic Marker;Protein Analysis;protein biomarkers;protein expression;Proteins;Proteomics;Protocols documentation;Pseudomonas aeruginosa;Pulmonary Inflammation;Research;Research Personnel;Resolution;response;Sampling;Sensitivity and Specificity;Serum;Source;specific biomarkers;Specific qualifier value;Specificity;Specimen;Stains;Staphylococcal Pneumonia;Stenotrophomonas maltophilia;Sterility;study population;Syndrome;System;Techniques;Time;Trypsin;Two-Dimensional Gel Electrophoresis;Virus Diseases

PROJECT_TITLE: Diagnostic and Prognostic Biomarkers in Pneumonia


PI_NAMEs: CHERTOW, DANIEL S (contact)

PROJECT_TERMS: Acute;Admission activity;Africa;Aliquot;Antibody Response;Bacteremia;Biological Assay;Blood specimen;Caring;Clinical;clinical center;Clinical Data;Clinical Trials;Convalescence;Critical Illness;Data;Databases;Diagnostic;Disease Outbreaks;Ebola;Ebola Hemorrhagic Fever;Ebola virus;efficacy evaluation;Electronics;Enrollment;Epidemiology;Flow Cytometry;Genetic;Genetic Transcription;Glycoproteins;Goals;Immunophenotyping;improved;Individual;Infection;Kinetics;Laboratories;Leukocytes;Liberia;Link;longitudinal analysis;Love;mathematical model;Molecular;Multiple Organ Failure;National Institute of Allergy and Infectious Disease;Natural History;older men;Outcome;pathogen;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Plasma Proteins;Proteome;Proteomics;Publishing;Recovery;Recrudescences;Research;response;Seminal fluid;Serum;Sierra Leone;single cell sequencing;Specimen;Supportive care;Survivors;Therapeutic;Time;United States National Institutes of Health;Vaccine Design;Viral;Viral Load result;Work

PROJECT_TITLE: Clinical and Molecular Features of Ebola Virus Disease


PI_NAMEs: GRADY, CHRISTINE P (contact)

PROJECT_TERMS: California;COVID-19 impact;COVID-19 pandemic effects;Data Analyses;Data Collection;Distress;Ethical Issues;Ethics;experience;Healthcare;Individual;Maryland;Massachusetts;member;Morals;Nurses;Ohio;Outcome;Patients;Personal Satisfaction;professional atmosphere;Registered nurse;Social Workers;Surveys;Time

PROJECT_TITLE: Ethical Experiences of Registered Nurses


PI_NAMEs: KADRI, SAMEER  (contact)

PROJECT_TERMS: Academic Medical Centers;Acute;Admission activity;Adrenal Cortex Hormones;Alberta province;Algorithms;Antibiotics;Antimicrobial Resistance;Bacterial Infections;beta-Lactams;Big Data;Biological Markers;Body mass index;booster vaccine;burden of illness;Canada;Candidiasis;Cardiac;Caring;Characteristics;Clindamycin;Clinical;Clinical Data;clinical epidemiology;Clinical Trials;Code;cohort;Collaborations;Communicable Diseases;Communities;community transmission;Consensus;cost;Country;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;COVID-19 risk;Critical Care;Critical Illness;cytokine;cytokine release syndrome;Data;Data Set;Death Rate;Development;Disease;Dose;drug repurposing;Electronic Health Record;epidemiologic data;Epidemiology;Exotoxins;FDA Emergency Use Authorization;Frequencies;Functional disorder;Generations;health care delivery;health care disparity;Healthcare;Hematologic Neoplasms;Heterogeneity;Hospital Mortality;Hospitalization;Hospitals;Hydroxychloroquine;Immune;improved;improved outcome;Incidence;indexing;Infection;infection rate;Inflammation;interest;Intravenous Immunoglobulins;Intubation;Investigation;Literature;Lower Respiratory Tract Infection;lung injury;Machine Learning;Measures;Mediating;medical schools;Medicine;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;mortality;Mortality Decline;mortality risk;Movement;Necrotizing fasciitis;Obesity;Observational Study;Oncology;Ontario;opioid use;opioid user;Organ;Outcome;Outcome Study;pandemic disease;Patient Admission;Patient Care;Patient Transfer;Patient-Focused Outcomes;Patients;Pattern;Performance;Pharmaceutical Preparations;Population;pre-pandemic;Prevalence;procalcitonin;Provider;Publishing;Quality of Care;randomized trial;Randomized, Controlled Trials;repository;Research;Research Personnel;Resources;respiratory;Risk;Risk Adjustment;Risk Factors;Rural;SARS-CoV-2 B.1.1.529;SARS-CoV-2 infection;Sepsis;Septic Shock;Severities;Severity of illness;Shock;smoke inhalation;Streptococcal Infections;Streptococcus Group B;Streptococcus pyogenes;Surveys;systematic review;T cell therapy;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;trend;Triage;Undifferentiated;United States;uptake;US State;Vaccination;Vaccinee;Validation;Variant;variants of concern;Vasoconstrictor Agents;ventilation;Ventilator

PROJECT_TITLE: Big Data - Epidemiology of Critical Illness and Sepsis


PROJECT_TERMS: acquired factor;Admission activity;Aminoglycosides;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteremia;beta-Lactams;Big Data;Blood;Carbapenems;Ceftazidime;Cephalosporin Resistance;Clinical;clinical database;Clinical effectiveness;clinically relevant;Colistin;Collaborations;Combined Antibiotics;Communicable Diseases;Communities;Consensus;Correlation Studies;COVID-19 pandemic;Critical Care;Data;Development;digital repositories;drug resistant pathogen;Electronic Health Record;epidemiologic data;Equipoise;Failure;Fluoroquinolones;Funding;Future;future pandemic;Health;Hospitals;improved;In Vitro;Industry;Infection;infection rate;Inpatients;Journals;Levaquin;Manuscripts;Marketing;Mediator;Medicine;meetings;Minimum Inhibitory Concentration measurement;mortality risk;Needs Assessment;New Agents;next generation;novel;Outcome;Outcomes Research;pathogen;Patients;Pattern;Phenotype;point-of-care diagnostics;Polymyxin B;Population;Predisposition;Prevalence;Prevalence Study;Publishing;Rapid diagnostics;repository;Research Personnel;Residual state;Resistance;Resistance profile;Risk Adjustment;Risk Factors;Role;Sepsis;Societies;Staphylococcus aureus;Stenotrophomonas maltophilia;Stream;Survival Rate;Testing;tigecycline;trend;trial comparing;Trimethoprim-Sulfamethoxazole;United States National Institutes of Health;Work

PROJECT_TITLE: Big Data- Epidemiology of Antimicrobial Resistance


PROJECT_TERMS: animal care;Animal Model;Animals;Antibiotics;Bacteremia;Clinical;Clinical Management;Critical Care;Critical Illness;Diagnosis;Dose;Ebola virus;Emerging infection;Escherichia coli;Failure;Functional disorder;Goals;Human;Immunologics;improved;Individual;Infection;Intensive Care Units;Intervention Trial;Klebsiella pneumoniae;Manuscripts;Modeling;Molecular;National Institute of Allergy and Infectious Disease;Organ;Pathogenesis;Peer Review;Phylogenetic Analysis;Physiological;Pilot Projects;Prevention approach;Publications;Publishing;Research;research facility;response;Sepsis;Severities;Supportive care;Syndrome;targeted treatment;Virus Diseases;Work

PROJECT_TITLE: Animal Models of Emerging Viral Infection


PI_NAMEs: QUEZADO, ZENAIDE  (contact)

PROJECT_TERMS: autism spectrum disorder;Behavior;behavior change;Behavioral;behavioral response;Belief;Caring;chronic pain;Communication;Communication impairment;comorbidity;Conscious;Development;Developmental Disabilities;Disadvantaged;Disease;Dyskinetic syndrome;Electroencephalography;Esthesia;experience;Face;functional near infrared spectroscopy;Galvanic Skin Response;Gene Mutation;Heart Rate;hemodynamics;High Prevalence;Hip region structure;Human;Immobilization;Impaired cognition;Incidence;indexing;Individual;Intellectual functioning disability;Judgment;Limb structure;Medical;Methods;Mobility decline;motor impairment;mouse model;Muscle Contraction;Mydriasis;Nature;Nervous System;neural;Neurobiology;Nociception;Operative Surgical Procedures;Osteopenia;Pain;Pain Measurement;pain processing;Pain Research;pain sensitivity;Pathological fracture;Patient Self-Report;Patients;Pattern;physically handicapped;Physiological;Population;Problem Solving;Rare Diseases;Reporting;Research;Research Personnel;response;Risk;Sampling;scoliosis;severe intellectual disability;skeletal abnormality;skills;social;somatosensory;Source;spasticity;spatial relationship;Spectrum Analysis;Stimulus;subluxation;Temporal Lobe;Thinking;verbal;Vulnerable Populations

PROJECT_TITLE: Neurobiology of pain and behavior changes associated with rare diseases and developmental disabilities


PROJECT_TERMS: Acute Pain;Advocacy;African ancestry;Agammaglobulinaemia tyrosine kinase;American Society of Hematology;Analgesics;Behavior;beta Globin;Blood Platelets;Body System;Cell Adhesion Molecules;Chronic;Clinical;Cognitive deficits;Complex;cytokine;Data;Development;diphosphoglycerate;Disease;efficacy testing;Erythrocyte Membrane;Erythrocytes;Etiology;Event;Functional disorder;Genes;Goals;health care disparity;Hematology;Hemoglobin;hemoglobin AA;Hemoglobin concentration result;hemoglobin polymer;Hemolysis;Hepatic;Human;improved;In Vitro;Individual;Inflammasome;Inflammation;Inflammatory;inhibitor;Injury;Leukocytosis;Life Expectancy;Liver;Macrophage;mast cell;Measurement;Mediating;Mitochondria;Molecular;Morbidity - disease rate;mouse model;Mus;Mutation;National Heart, Lung, and Blood Institute;National Institute on Minority Health and Health Disparities;Neutrophil Activation;novel;novel strategies;novel therapeutics;Organ;organ injury;Outcome;Oxidative Stress;Pain;Pain management;pain sensitivity;Parents;Pathway interactions;Patients;pharmacologic;Platelet aggregation;polymerization;Polymers;pre-clinical;preclinical evaluation;programs;Protein Kinase;Pyruvate Kinase;Quality of life;Recurrence;Sickle Cell;Sickle Cell Anemia;Sickle Hemoglobin;sickling;societal costs;Therapeutic;Therapeutic Agents;Thrombus;Vascular Endothelium;Work

PROJECT_TITLE: Pathobiology of pain in sickle cell disease


PROJECT_TERMS: Acute;Acute Pain;Acute pain management;Adjuvant;Adjuvant Analgesic;Admission activity;Adolescent;Adolescent obesity;Adult;Afferent Neurons;Age;Agonist;Analgesics;Anesthetics;Animals;antagonist;antinociception;awake;bariatric surgery;Brain;cancer pain;central sensitization;Cerebrum;Characteristics;Chest Pain;Child;Childhood;Chronic;chronic pain;chronic pain management;Chronic pain syndrome;Clinical;clinical diagnosis;Clinical Research;cohort;Communication Disability;Complex Regional Pain Syndromes;Consensus;Data;design;Development;Developmental Disabilities;Dexmedetomidine;Dose;efficacy testing;experimental study;Expert Opinion;FMR1 gene;Fragile X Syndrome;functional disability;Goals;Hospitals;Human;Hyperalgesia;improved;in vivo;inflammatory pain;Infusion procedures;Inpatients;Ketamine;Laboratories;Location;male;Measurement;Measures;Modeling;Mood Disorders;mouse model;Multivariate Analysis;Mus;N-Methyl-D-Aspartate Receptors;Nitric Oxide;Nociception;non-opioid analgesic;novel;novel strategies;novel therapeutic intervention;Opioid;Opioid Receptor;opioid use;Outpatients;Pain;Pain intensity;Pain management;pain model;pain reduction;pain score;pain sensitivity;painful neuropathy;Participant;Patient Admission;Patients;pediatric patients;Perioperative;Pharmacological Treatment;Phenotype;Postoperative Period;postsynaptic;pre-clinical;Pre-Clinical Model;Property;Protein Biosynthesis;randomized, clinical trials;Rare Diseases;Receptor Activation;Role;safety and feasibility;Sampling;Sedation procedure;sedative;sex;Sickle Cell;Sickle Cell Anemia;side effect;Tonsillectomy;treatment duration;treatment strategy;Visceral pain;Work

PROJECT_TITLE: Development of novel strategies for the treatment of pain in children


PROJECT_TERMS: 2019-nCoV;Acute;Autopsy;Biological Markers;Brain;Bronchoalveolar Lavage;Caring;Cellular Tropism;Clinical;clinical center;Clinical Data;Clinical Research;cohort;Collaborations;COVID-19;COVID-19 mortality;COVID-19 pandemic;COVID-19 patient;Critical Illness;Data;Disease;Drug or chemical Tissue Distribution;Evolution;Extracorporeal Membrane Oxygenation;Goals;Human;Human body;Immune;Immune response;Immunologics;improved;Individual;insight;Investigation;Kinetics;Laboratories;Manuscripts;Maryland;Medical center;Molecular;nasopharyngeal swab;Natural History;oropharyngeal swab;participant enrollment;pathogen;pathogenic virus;Pathologic;Peripheral Blood Mononuclear Cell;Plasma;Preparation;preservation;Publishing;Recovery;Research;response;Sampling;severe COVID-19;Therapeutic;thrombotic;United States National Institutes of Health;Universities;unvaccinated;Vaccine Design;Vaccines;Variant;Viral;Virus;Work

PROJECT_TITLE: Clinical and Molecular Features of Coronavirus Disease 2019


PROJECT_TERMS: Benefits and Risks;Clinical Research;Common Good;Communities;Data;Ethics;Human;Informed Consent;Investigation;Literature;Methods;Monitor;Participant;participant enrollment;Publishing;recruit;Research;Research Design;Research Ethics;Science;Social Values

PROJECT_TITLE: Challenges in Research Ethics


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: BEWLEY, CAROLE  (contact)

PROJECT_TERMS: 2019-nCoV;Antigens;Binding Sites;Biochemical;Bispecific Antibodies;carbohydrate binding protein;carbohydrate receptor;Carbohydrates;chimeric antibody;Coronavirus;cost;Cryoelectron Microscopy;design;design and construction;Development;Disease;Drug resistance;drug resistance development;Engineering;env Gene Products;Foundations;Glycoproteins;Goals;Hepatitis C virus;HIV;HIV Envelope Protein gp120;HIV-1;HIV/AIDS;Human;Immune system;in vivo;Individual;Infection;inhibitor;Life Expectancy;Local Microbicides;Mannose;Mannose Binding Lectin;Mediating;Natural product discovery;NMR Spectroscopy;novel;Oligosaccharides;Peptides;Polysaccharides;Prevention strategy;Protein Engineering;Proteins;Publications;receptor;receptor binding;Research;Site;small molecule;small molecule inhibitor;small molecule therapeutics;Structure;Therapeutic;Therapeutic Uses;Translating;Translations;Vaccine Design;vaccine development;Vaccines;Viral;Viral Genome;Viral Proteins;Virus;virus envelope;Work;X-Ray Crystallography

PROJECT_TITLE: HIV Neutralization Inhibitors: Engineering, characterization, and functions


NIH_SPENDING_CATS: Cancer;Clinical Research;Rare Diseases

ORG_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PI_NAMEs: KLUBO-GWIEZDZINSKA, JOANNA  (contact)

PROJECT_TERMS: Adult;Adverse event;Benign;Blood specimen;cancer cell;Cancer Patient;Cardiac;Case/Control Studies;cohort;Cohort Studies;Confidence Intervals;Diagnosis;Diagnostic;Disease;Disease-Free Survival;Excision;Exclusion;Fine needle aspiration biopsy;follow-up;Guidelines;hazard;Heterogeneity;high risk;immunohistochemical markers;Incidence;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Meta-Analysis;Methods;Modeling;Molecular;molecular marker;Multiple Endocrine Neoplasia Type 2a;Natural History;Nodule;Operative Surgical Procedures;Outcome;Outcome Assessment;Outcome Measure;Patient Participation;patient screening;Patients;prevent;primary outcome;Prognosis;Progression-Free Survivals;Protocols documentation;Radioactive Iodine;Randomized, Controlled Trials;Recommendation;Recurrent disease;Reference Values;Relapse;research study;Risk;Role;Sampling;Scanning;screening;secondary outcome;skeletal;Specimen;standard care;Study Subject;survival outcome;systematic review;Techniques;Text;Thyroid Diseases;Thyroid Gland;Thyroid Hormones;Thyroid Nodule;Thyrotropin;Thyrotropin Receptor;Tissues;treatment response;tumor;tumor growth

PROJECT_TITLE: Studies of Benign and Malignant Thyroid Disease


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

PI_NAMEs: CAMERINI-OTERO, RAFAEL  (contact)

PROJECT_TERMS: Affect;African;Alleles;base;Binding;Binding Sites;Biochemistry;Biological Assay;Cell Nucleus;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Chromosomes;cohesin;Collaborations;Consensus;CRISPR/Cas technology;CYP2D6 gene;density;Detection;Development;Distant;DNA biosynthesis;DNA sequencing;Drug Prescriptions;Elements;Enhancers;Epigenetic Process;Eukaryota;Exhibits;Foundations;functional genomics;Genes;Genetic Crossing Over;Genetic Determinism;Genetic Predisposition to Disease;Genetic Recombination;Genome;genome-wide;Goals;Health Sciences;Heterozygote;Hi-C;High-Throughput Nucleotide Sequencing;Human;human male;human population genetics;in silico;In Situ;Individual;insight;interest;Laboratories;Libraries;Link;Location;male;mammalian genome;Mammals;Maps;Meiosis;Meiotic Prophase I;Meiotic Recombination;Methods;Methylation;Methyltransferase;Mitotic;Modeling;Molecular Biology;MSH4 gene;Mus;Nature;novel;Nucleosomes;Nucleotides;Organism;Pattern;Play;Population;Positioning Attribute;preference;Preparation;Procedures;Process;promoter;Proteins;Pseudogenes;Replication Initiation;Replication Origin;Resolution;Role;S phase;Science;Sex Bias;Sex Differences;Shapes;Signal Transduction;Single-Stranded DNA;Site;Sorting;Specificity;Spermatocytes;Spermatogenesis;Spermatogonia;SS DNA BP;Technology;telomere;Testis;Time;Transcription Initiation Site;University Health Services;Variant

PROJECT_TITLE: What determines the location of meiotic crossovers in the mammalian genome?


PI_NAMEs: WESS, JURGEN  (contact)

PROJECT_TERMS: Acetylcholine;Adenosine;Adipocytes;ADORA2A gene;ADRBK1 gene;Adult;Agonist;Alpha Cell;Arrestin Beta 1;autocrine;beta-arrestin;Binding;Blood Glucose;blood glucose regulation;cell type;Clozapine;Coupled;Coupling;Cre driver;Critical Pathways;designer receptors exclusively activated by designer drugs;Development;Diabetes Mellitus;Disease;drug development;Endowment;Ensure;Enteroendocrine Cell;Family;Functional disorder;G protein coupled receptor kinase;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;G12 Protein;gain of function;gastric inhibitory polypeptide receptor;Genes;Genetic;Glucagon;Glucose;glucose metabolism;glucose production;glucose tolerance;Goals;GTP-Binding Proteins;Health;Hepatic;Hepatocyte;Homeostasis;Hormones;Human;Hypothalamic structure;Impairment;improved;in vivo;insight;Insulin;Insulin Resistance;insulin sensitivity;Investigation;Investments;islet;Killer Cells;Knockout Mice;Ligands;Link;Lipids;Liver;liver function;loss of function;MAPK8 gene;Mediating;Membrane;Metabolic;metabolic abnormality assessment;Metabolic Diseases;Metabolic Pathway;metabolic phenotype;Methamphetamine;Molecular;mouse model;Mouse Strains;Mus;Muscarinic Acetylcholine Receptor;Muscle Fibers;mutant mouse model;Mutant Strains Mice;Nature;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel;novel drug class;novel therapeutics;Obesity;overexpression;Oxides;paracrine;Paracrine Communication;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Physiological;Physiology;Plasma;Play;Point Mutation;Process;proglucagon;Property;receptor;Regulation;ROCK1 gene;Role;Signal Pathway;Signal Transduction;Structure;Structure of alpha Cell of islet;Structure of beta Cell of islet;Tamoxifen;Technology;Therapeutic;Tissues;tool;virtual;Wing;Work

PROJECT_TITLE: Role of G protein-coupled receptors in regulating glucose and energy homeostasis


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Patient Safety;Radiation Oncology

PROJECT_TERMS: absorption;Adult;Adult women;Adverse event;Aftercare;Agonist;analog;anti-cancer research;Askenazy Cells;Blood;Bone Marrow;Case Series;Clinical;cohort;Diagnosis;Diagnostic Imaging;Dose;Dose Limiting;dosimetry;efficacy evaluation;Enrollment;Evaluable Disease;Event;Exposure to;follow-up;Histologic;improved;in vivo Model;Kidney;lean body mass;Lesion;Liver;male;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Methods;molecular targeted therapies;Neuroendocrine Tumors;Normal Range;novel;objective response rate;open label;Organ;Oxyphil Cells;Participant;Patients;Pharmaceutical Preparations;Phase;phase 1 designs;Phase I/II Clinical Trial;Pituitary Gland;pre-clinical;Progression-Free Survivals;Quality of Life Assessment;Questionnaires;Radioactive Iodine;radioiodine therapy;Radiolabeled;Refractory;Regimen;residence;response;Safety;safety study;Somatostatin Receptor;somatostatin receptor 2;Spleen;Standardization;Therapeutic;Thyroglobulin;Thyroglobulin antibody;Thyroid Diseases;Thyroid Gland;Thyroid Nodule;Thyroidectomy;Time;Toxic effect;Treatment Efficacy;tumor;Tumor Markers;United States National Institutes of Health;uptake

PROJECT_TITLE: Somatostatin receptors in the diagnosis and treatment of thyroid cancer


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

PROJECT_TERMS: Age;Benign;cancer risk;Characteristics;Clinical Data;ClinVar;Data;Databases;Diagnostic;diagnostic accuracy;Diagnostic Procedure;DNA;exome sequencing;Family;Follicular thyroid carcinoma;Formalin;Foundations;FUS-1 Protein;General Population;Genomics;Goals;Growth;guanine nucleotide binding protein;improved;KRAS2 gene;Libraries;Malignant - descriptor;Malignant neoplasm of thyroid;Malignant Neoplasms;Methods;Modeling;Molecular;molecular diagnostics;Molecular Profiling;Monomeric GTP-Binding Proteins;Mutation;Nuclear Receptors;Ovarian Teratoma;Papillary thyroid carcinoma;Paraffin Embedding;Pathogenicity;Patients;Process;receptor binding;risk stratification;RNA;RNA Splicing;Role;Sampling;SET Domain;Site;Therapeutic procedure;Thyroglobulin;Thyroid Gland;Thyroid Nodule;Thyroidectomy;Tissue Sample;Tissues;TP53 gene;transcriptome sequencing;transcriptomics;tumor;Tumor Tissue;ultrasound;Unnecessary Surgery;Variant;Woman

PROJECT_TITLE: Application of molecular diagnostics in thyroid cancer


PROJECT_TERMS: aerobic glycolysis;Affect;Binding;BRAF gene;Cancer cell line;Carbohydrates;Categories;Cells;Cellular Metabolic Process;Characteristics;Citric Acid Cycle;cohort;Combined Modality Therapy;Deoxyglucose;Expression Profiling;FRAP1 gene;Functional Imaging;Gene Expression;Genes;Genetic;genetic analysis;Genotype;Glucose;glucose metabolism;glucose uptake;Glycolysis;Goals;Growth;Human;Image;In Vitro;in vitro Model;Knowledge;Lesion;Malignant neoplasm of thyroid;MAP Kinase Gene;MEKs;Metabolic;Metabolic Pathway;metabolic phenotype;metabolomics;Molecular Profiling;mutant;Mutation;neoplastic cell;Oncogenes;Oxidative Phosphorylation;Oxygen;Pathway interactions;Performance;PI3K/AKT;Play;Population;Positron-Emission Tomography;precision medicine;Radioactive Iodine;Regulation;Role;Signal Pathway;Signal Transduction;SLC5A5 gene;Stromal Cells;targeted treatment;Testing;The Cancer Genome Atlas;Tissue Sample;transcriptomics;tumor;tumor growth;tumor metabolism;uptake;Warburg Effect

PROJECT_TITLE: Cross-talk between oncogene-driven signaling pathways and thyroid cancer metabolism


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: MCPHERSON, CHRISTOPHER ANTHONY (contact)

PROJECT_TERMS: 3-Dimensional;Address;Adoption;Animal Model;Apoptosis;Astrocytes;Behavior;Behavioral;Biological Assay;Botanicals;brain cell;Cannabinoids;Case Study;cell type;Chemical Exposure;Chemicals;Communication;Communities;Contracts;Data;data integration;data visualization;Decision Making;Development;developmental neurotoxicity;Drosophila genus;environmental chemical;Evaluation;Event;Experimental Designs;exposed human population;Exposure to;Flame Retardants;fungicide;Goals;hazard;Health;Herbicides;Histology;Home;Human;human induced pluripotent stem cells;human migration;improved;in silico;In Vitro;in vitro Assay;in vivo;in vivo Model;Industrialization;innovation;Insecticides;International;Knowledge;Laboratories;Libraries;Link;Magnetic Resonance;Manuscripts;Methods;Microglia;migration;Mission;Modeling;Monitor;Movement;multi-electrode arrays;nerve stem cell;Nervous System Physiology;Neural Crest Cell;neural network;Neurites;neuroimaging;Neurons;Neurosphere;Neurotoxins;novel;Organophosphates;Outcome;Pattern;Pharmaceutical Preparations;Phase;phase 1 testing;phase 2 testing;Planarians;Preparation;Process;programs;Proliferating;Public Health;Quality Control;Rattus;Research;Resources;response;Rodent;Running;screening;small molecule libraries;Structure;synaptogenesis;Technology;Testing;Therapeutic;Toxic effect;Update;Visualization;web app;Weight;Xenobiotics;Zebrafish

PROJECT_TITLE: Developmental Neurotoxicity Health Effects Innovation Research Program


ACTIVITY: ZIC

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging

ORG_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PI_NAMEs: RANDAZZO, DAVIDE  (contact)

PROJECT_TERMS: Algorithms;Area;Automobile Driving;Carbon Dioxide;career;Cell membrane;Cells;cellular imaging;charge coupled device camera;Collaborations;Color;Communities;Complex;Computer software;Confocal Microscopy;Core Facility;Coupled;Darkness;Detection;detector;digital;Dyes;Elbow;Electrons;Elements;Equipment;Ethics;Event;Exocytosis;experimental study;flasks;flexibility;Fluorescence;Fluorescence Microscopy;fluorophore;gallium arsenide;Genomics;Glass;Heating;high resolution imaging;Histology;Histopathology;Humidity;Hybrids;Image;image processing;imager;imaging capabilities;imaging facilities;Imaging Techniques;improved;Incubators;Individual;innovation;instrument;Knowledge;Label;Lasers;Lateral;lens;Light;light transmission;Lightning;lightspeed;live cell imaging;Manufacturer;Marketing;Mathematics;member;metal oxide;Methodology;Methods;Microscope;microscopic imaging;Microscopy;Mission;Motor;multiplexed imaging;National Heart, Lung, and Blood Institute;National Human Genome Research Institute;National Institute of Allergy and Infectious Disease;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;National Institute of Child Health and Human Development;Noise;optical lattices;Optics;Ownership;Philosophy;Photobleaching;photomultiplier;Photons;Phototoxicity;Process;Reporting;Research Personnel;Research Project Grants;Resolution;Running;Sampling;sapphire laser;Scanning;Scientist;second harmonic generation imaging;Semiconductors;Series;Shapes;Slide;Solid;solid state;Source;Speed;Stains;submicron;superresolution imaging;superresolution microscopy;System;Techniques;Technology;Temperature;Thick;Time;Tissues;tool;Training;transcriptomics;Tube;two-photon;ultra high resolution;virtual;Work;Writing

PROJECT_TITLE: NIAMS Light Imaging Facility


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease

PI_NAMEs: TRAN, DUY  (contact)

PROJECT_TERMS: Biology;Communities;Data Analyses;Development;Environment;Epithelium;Equipment;Experimental Designs;experimental study;Goals;Histology;Hour;Image;imaging approach;imaging modality;imaging platform;imaging system;Immunology;Individual;Inflammation;Infrastructure;instrumentation;Learning;Life Cycle Stages;Microbiology;Microscope;Mission;National Institute of Dental and Craniofacial Research;outreach;Pain;Preparation;programs;Research;Research Personnel;Research Support;Running;Salivary Glands;Sampling;Sensory;Series;Services;skeletal;stem cell fate;theories;Tissues;Training;Work

PROJECT_TITLE: Imaging Core


NIH_SPENDING_CATS: Prevention

ORG_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PI_NAMEs: KLEINSTREUER, NICOLE  (contact)

PROJECT_TERMS: Animal Model;animal pain;Animals;Biochemical;Bioinformatics;Cells;chemical safety;Chemicals;Communication;Communities;computational toxicology;Computer Models;Data;Development;Distress;Educational workshop;Evaluation;Fostering;Funding Opportunities;improved;Interagency Coordinating Committee on the Validation of Alternative Methods;interest;International;Knowledge;Medical;method development;Methods;Mission;Mus;National Institute of Environmental Health Sciences;National Toxicology Program;novel strategies;Operations Research;Personal Satisfaction;Procedures;Public Health;Publishing;Recommendation;Research;safety testing;symposium;System;Testing;Toxicity Tests;Toxicology;United States;Validation;web site;Work

PROJECT_TITLE: Research Operations Supporting the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods


NIH_SPENDING_CATS: Complementary and Integrative Health;Dietary Supplements;Natural Products

PI_NAMEs: WAIDYANATHA, SURAMYA  (contact)

PROJECT_TERMS: absorption;Academia;ADME Study;Agreement;analytical method;Animal Model;Animals;Biological;Biological Assay;Botanical dietary supplements;Budgets;Cells;Chemical Agents;Chemicals;Chemistry;Complex Mixtures;Consumption;Contract Services;Contracts;Data;Data Reporting;design;Development;Dyes;Ensure;Environment;Environmental Pollutants;Excretory function;exposed human population;Exposure to;Flame Retardants;Formulation;Fractionation;Goals;Health;Heavy Metals;Human;Human Resources;improved;in silico;In Vitro;in vitro Model;in vivo;in vivo Model;Industry;Inhalation;inorganic phosphate;Isomerism;Knowledge;Liver;Materials Testing;Metabolism;metabolomics;method development;Mission;multidisciplinary;National Institute for Occupational Safety and Health;National Institute of Environmental Health Sciences;novel;operation;Oral;Outcome;Phytochemical;Plasma;programs;Proteomics;Public Health;Rattus;Reporting;Research;Research Contracts;Resources;Rodent;Rodent Model;Sampling;Scientist;screening;Services;System;Techniques;Testing;Toluene;Toxic effect;Toxicokinetics;Toxicology;Translating;Valerian;Validation;Vision;Work

PROJECT_TITLE: Chemistry Services Supporting the Division of Translational Toxicology


ADMINISTERING_IC: CK

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: KINSHASA

ORG_COUNTRY: CONGO DEM REP

ORG_FIPS: CG

ORG_NAME: KINSHASA SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative Zoonotic diseases like Monkeypox and Ebola virus disease are a significant public health threat in Democratic Republic of the Congo (DRC) and have a high risk of international exportation. This project aims to improve the ability of DRC to respond to zoonotic diseases by developing rigorous surveillance systems, investigating medical countermeasures and clinical treatments, identifying key risk factors in primary transmission of disease, and creating a resilient interdisciplinary public health workforce.

PI_NAMEs: KABA, DIDINE KINKODI (contact)

PROJECT_TITLE: RFA-CK-22-001, Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC) - 2022


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Clinical Research;Complementary and Integrative Health;Eye Disease and Disorders of Vision;Precision Medicine

ORG_CITY: CHICAGO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NATIONAL OPINION RESEARCH CENTER

ORG_STATE: IL

PI_NAMEs: LEINTZ, JEFFREY ;SMITH, STEPHEN  (contact)

PROGRAM_OFFICER_NAME: JAWORSKI, BETH KRISTEN

PROJECT_TERMS: Address;Age;All of Us Research Program;Ancillary Study;Behavior;Characteristics;Chicago;Child;Code;Collaborations;Communication;Communities;Complex;Data;Data Collection;Data Set;design;Disability status;Disclosure;Educational Status;Enrollment;Ensure;Ethnic Origin;experience;flexibility;Future;Gender Identity;Genetic;Geographic Locations;Goals;Health Status;improved;Knowledge;Measures;Methodology;Methods;Monitor;multimodal data;operation;outreach;Participant;participant enrollment;patient engagement;Patient Recruitments;Phase;Physical activity;Population;Population Group;Population Heterogeneity;precision medicine;Process;programs;Protocols documentation;Race;Recording of previous events;recruit;remote assessment;Reporting;Research;Research Design;Research Personnel;research study;Research Support;Secure;Services;Sex Orientation;Socioeconomic Status;success;System;Technical Expertise;Technology;technology platform;Testing;Time;tool;United States National Institutes of Health;Universities;user-friendly;wearable device;Work

PROJECT_TITLE: Partnering for Precision Medicine: A Collaborative Services Center for the All of Us Program


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: ROUND ROCK

ORG_NAME: DELL FEDERAL SYSTEMS L.P.

ORG_STATE: TX

PHR: No PHR

PI_NAMEs: HAMMONDODWYER, AMY K (contact);SIDDIQUI, ERUM

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Services;Training;United States National Institutes of Health

PROJECT_TITLE: NIH STRIDES - Azure and Associated Services and Training.


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: BOCA RATON

ORG_DEPT: CHEMISTRY

ORG_NAME: FLORIDA ATLANTIC UNIVERSITY

ORG_STATE: FL

PHR: NARRATIVE Bacteria, differently from mammals, assimilate inorganic sulfur into the amino acid, L-cysteine, the precursor of key metabolites including reducing agents, cofactors and membrane components. Inhibition of cysteine biosynthesis interferes with the ability of pathogens to fight oxidative stress, to infect the host and to establish long-term infections. The proposed research is expected to lead to a new class of antibacterial agents that operate by a unique mechanism of action through disruption of sulfur metabolism.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Sulfur Metabolism in Human Pathogens

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Hematology;Mental Health;Neurosciences;Pain Research;Pediatric;Rare Diseases;Rehabilitation;Sickle Cell Disease;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE) will be the first study to compare the effectiveness of a cognitive behavioral therapy (CBT) program with and without peer support to usual care as a non-pharmaceutical option for pain management in people living with sickle cell disease. CBT is delivered through an innovative digital app that is accessed on a mobile device with one group receiving self-guided CBT and the other receiving CBT plus peer support. The PRESENCE program is comprised of strong community partnerships that provide the peer support component of the intervention.

PI_NAMEs: COLVIN, ALICIA ;JONASSAINT, CHARLES RICHARD (contact);RADOVIC-STAKIC, ANA

PROGRAM_OFFICER_NAME: LOUDEN, ANDREW

PROJECT_TERMS: Address;Adolescent;Adolescent and Young Adult;adolescent health outcomes;Advocate;Age;Anxiety;Behavioral;behavioral health;Black race;Caring;Chronic;chronic pain;Clinical;clinical research site;Cognitive;Cognitive Therapy;community organizations;community partners;community partnership;compare effectiveness;coping;cost;daily pain;Data;design;Development;diaries;digital;digital applications;digital intervention;digital treatment;Disparity;E-learning;Education;Educational process of instructing;Effectiveness;effectiveness evaluation;Emergency department visit;emerging adult;Empathy;Enrollment;evidence base;Exercise;experience;Exposure to;Family member;Focus Groups;Future;General Population;handheld mobile device;healing;health care service utilization;Healthcare Systems;Hospitalization;human centered design;implicit bias;improved;Individual;Infrastructure;innovation;internalized stigma;Intervention;Learning Skill;Libraries;Lived experience;meetings;Mental Depression;Mental Health;Minority Groups;Moods;Multicenter Trials;National Center for Advancing Translational Sciences;non-opioid analgesic;Opioid;opioid use;Outcome;Pain;Pain intensity;Pain interference;Pain management;pain outcome;pain reduction;pain symptom;Parents;Participant;patient engagement;Patients;peer;peer coaching;peer support;personalized approach;personalized learning;Persons;Phase;Population;preference;prescription opioid;primary outcome;programs;Provider;psychologic;psychological outcomes;psychological symptom;psychosocial;racial bias;Randomized;randomized trial;Randomized, Controlled Trials;Reporting;Research Design;Resources;Running;secondary outcome;Secondary pain;Secure;Sickle Cell;Sickle Cell Anemia;Site;social stigma;Stress;stressor;support network;Symptoms;Technology;telephone based;Testing;Text;Therapeutic Intervention;Therapy trial;Training;transition to adulthood;treatment as usual;treatment group;uptake;video chat;virtual delivery;Voice;Work


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PI_NAMEs: WILKIE, DIANA J (contact)

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TITLE: Administrative Core - 2/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center


PI_NAMEs: LEE, JI-HYUN  (contact)

PROJECT_TITLE: Bioinformatics, Statistical and Methodological Shared Resources Core


PI_NAMEs: OKUNIEFF, PAUL  (contact)

PROJECT_TITLE: Tissue Modeling & Drug Development Shared Resources Core


PI_NAMEs: SCHMITTGEN, THOMAS D. (contact)

PROJECT_TITLE: Project 3 ADM


PI_NAMEs: HUANG, YONG  (contact)

PROJECT_TITLE: Project 4 LUNG


PI_NAMEs: ROGERS, SHERISE C. (contact)

PROJECT_TITLE: Pilot Project 5


PI_NAMEs: EZENWA, MIRIAM OMELEBELE (contact)

PROJECT_TITLE: Planning and Evaluation Core


PI_NAMEs: ALLEN, JOHN M (contact)

PROJECT_TITLE: Research Education Core


PI_NAMEs: WEBB, FERN JUREIDINI (contact)

PROJECT_TITLE: Community Outreach Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Precision Medicine;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The All of Us Research Program is building a cohort of over a million individuals who consent for the use of their data and biospecimens for health-related research. The Coast-to-Coast (C2C) Consortium is composed of a set of healthcare provide organizations that help All of Us recruit, retain, and facilitate interactions with the populations cared by their health systems.

PI_NAMEs: BOROWSKY, ALEXANDER D;GOODMAN, MARC T;HIATT, ROBERT A;KIM, SUE ELIZABETH;MEEKER, DANIELLA ;MONTALVO-ORTIZ, JANITZA LIZ;OHNO-MACHADO, LUCILA  (contact);SILVA, AMARILYS ;SITAPATI, AMY MONTAGUE

PROGRAM_OFFICER_NAME: ALEXANDER-TROUPE, STEPHANIE MELANIA

PROJECT_TERMS: Absenteeism at work;All of Us Research Program;Area;Awareness;Biomedical Research;Blood Banks;California;Catchment Area;Childhood;Church;Clinic;clinical infrastructure;clinical research site;Collaborations;collaborative environment;Collection;Communication;Communities;Community Healthcare;community organizations;community partners;Complement;Computers;Connecticut;Consent;Contract Services;cost;cost estimate;Costs and Benefits;Country;Creativeness;Data;data dictionary;data exchange;data sharing;Decision Making;Disease;Doctor of Philosophy;Education;Electronic Health Record;Enrollment;Equilibrium;ethnic minority population;Ethnic Origin;Ethnic Population;Event;experience;Faith-based organization;Geography;Goals;Grant;Growth;Health;Health Insurance Portability and Accountability Act;Health Personnel;Health system;Healthcare;Hot Spot;implementation science;improved;Income;Information Technology;Infrastructure;innovation;Institution;Internet;Joints;Knowledge;Latinx;Leadership;Learning;lens;Life Cycle Stages;literacy;Location;Low income;male;Marketing;Measurement;Medical center;member;Mission;Modeling;Monitor;multidisciplinary;novel;Outcome;outreach;outreach program;Participant;patient outreach;Patient Schedules;Patients;pediatrician;Persons;Population;Population Heterogeneity;Poverty;Precision Health;precision medicine;precision nutrition;Process;programs;Provider;Puerto Rico;Qualifying;Race;racial minority population;racial population;recruit;Research;Research Institute;retention rate;Retrieval;Rhode Island;Rural;rural area;rural setting;safety net;Schedule;Site;skills;Socioeconomic Status;socioeconomics;Spanish;success;Support Groups;System;Training;Underserved Population;United States;United States National Institutes of Health;Universities;urban setting;volunteer;Vulnerable Populations;wireless fidelity;Work;Youth

PROJECT_TITLE: Ocular Image Study for All of Us at Yale and UCSD


NIH_SPENDING_CATS: Asthma;Estrogen;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health;Women's Health Research

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: NARRATIVE Sex and gender disparities in the severity and frequency of asthma exacerbations have been extensively reported, yet the biological and hormonal basis of these differences have not been elucidated. Here, we investigate the mechanisms by which estrogen triggers inflammation in the male and female asthmatic lung. Our findings will determine the molecular basis of hormonal triggers of asthma exacerbations in cis and transgender women and lead to the future development of better personalized therapeutic options for lung disease.

PI_NAMEs: SILVEYRA, PATRICIA  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Accounting;Adult;Adult women;Affect;Agonist;Air Movements;Air Pollution;airway hyperresponsiveness;airway obstruction;Allergens;antagonist;Asthma;asthma exacerbation;asthma model;asthma prevention;asthmatic;asthmatic patient;Automobile Driving;Award;Binding;Biological;bronchial epithelium;Cells;cis-female;cost;cytokine;Data;Development;Diagnosis;differential expression;Disease;Disparity;dosage;Environmental Exposure;Environmental Risk Factor;Epithelial Cells;Estradiol;Estrogen Receptors;Estrogens;Estrous Cycle;Experimental Models;experimental study;Exposure to;Female;female sex hormone;Feminization;Four Core Genotypes;Frequencies;Future;Gender;gender difference;gender disparity;Gene Expression;Genes;Genomics;Goals;Gonadal Hormones;Gonadal Steroid Hormones;GPER gene;Health;Hormonal;hormone therapy;Hormones;Hospitalization;House mice;Human;Incidence;Individual;Individual Differences;Inflammation;Inflammatory;Inflammatory Response;Knockout Mice;Knowledge;Laboratories;Life;Liquid substance;Lung;Lung Diseases;male;Measures;Mediating;Mediator;Membrane;men;Menstrual cycle;Menstruation;middle age;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;National Heart, Lung, and Blood Institute;non-genomic;novel therapeutics;Nuclear;Orchiectomy;Outcome;Ovariectomy;Pathway interactions;Patients;personalized therapeutic;Phenotype;Physiological;Ploidies;Population;Prevalence;prevent;Puberty;Public Health;Pulmonary Inflammation;Pyroglyphidae;Receptor Signaling;Recommendation;Recording of previous events;Reporting;Research;Research Priority;respiratory;Respiratory Failure;response;Role;Severities;sex;sex as a biological variable;Sex Chromosomes;Sex Differences;sex disparity;Signal Transduction;Stimulus;Strategic Planning;Structure of parenchyma of lung;Symptoms;Testing;Therapeutic Agents;transgender;transgender women;United States National Institutes of Health;Variant;Woman;Women's Health;Women's Role;women's treatment

PROJECT_TITLE: Gonadal hormones as mediators of sex and gender influences in asthma


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Complementary and Integrative Health;Microbiome;Neurosciences;Nutrition;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Alcohol consumption is the leading risk factor for premature death in individuals ranging from 15 to 49 years of age. Mounting evidence indicates a role for the gut microbiota in behavioral, gastrointestinal, and inflammatory consequences of alcohol consumption that may contribute to relapse. This proposal will provide critical training in cutting edge approaches for quantifying the relationships between alcohol seeking, reward-related decision- making, and the gut microbiota with the goal of investigating novel treatment options for alcohol use disorders.

PI_NAMEs: THOMPSON, SUMMER LORETTA (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Accounting;addiction;Age Years;alcohol consequences;Alcohol consumption;alcohol effect;alcohol exposure;alcohol research;alcohol reward;alcohol seeking behavior;alcohol testing;alcohol use disorder;Alcohol withdrawal syndrome;Alcohol-Induced Disorders;Alcohols;alternative treatment;Antibiotics;Bacteria;Behavior;behavior measurement;Behavior Therapy;Behavioral;behavioral impairment;Behavioral Mechanisms;Bioinformatics;Biological Models;career;Career Mobility;Cessation of life;Chronic;chronic alcohol ingestion;Clinical;Cognition;Cognitive;Communication;Computer Models;Data;Decision Making;Development;Diet;disability;Donor person;Ensure;experience;experimental study;feasibility testing;fecal transplantation;Fiber;gastrointestinal;Gastrointestinal tract structure;Goals;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Heavy Drinking;host-microbe interactions;Human;Impairment;Individual;Inflammation;Inflammatory;Instruction;Intestinal permeability;Intestines;Knowledge;Learning;Measures;Mediating;Memory;Mental disorders;Mentors;Mentorship;metagenomic sequencing;Microbiology;microbiota;Modeling;Molecular Biology;mouse model;Mus;Nervous System;neuromechanism;Neurosciences;new therapeutic target;novel;Operant Conditioning;Play;Positioning Attribute;prebiotics;premature;programs;Public Health;Recording of previous events;Regimen;Relapse;Research;reward processing;Rewards;Risk Factors;Rodent;Rodent Model;Role;Self Administration;Shotguns;skills;stool sample;systemic inflammatory response;Techniques;Testing;Therapeutic;tool;Training;treatment strategy;Withdrawal Symptom

PROJECT_TITLE: The role of the gut microbiota in alcohol seeking and decision-making

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Liver Disease;Prevention;Primary Health Care;Rural Health;Social Determinants of Health

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE We propose to enlarge the target sample size of the current project’s 2 pilot studies involving fatty liver disease by 600 participants, and to extend the study from the City and County of Honolulu on the island of Oahu to rural community primary care clinics on the neighbor islands - the Big Island of Hawaii, Kauai and Molokai.

PI_NAMEs: BALARAMAN, VENKATARAMAN ;SETO, TODD B;SHIKUMA, CECILIA M. (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Administrative Supplement;Adult;Advocate;Affect;Agriculture;Area;Cities;Clinical Research;Code;community clinic;community setting;County;Diabetes Mellitus;Early Diagnosis;ethnic diversity;Evaluation;Fatty acid glycerol esters;Fatty Liver;fatty liver disease;Federally Qualified Health Center;Fibrosis;food insecurity;Goals;Grant;Hawaii;health disparity;health equity;Health Policy;HIV;Home;Homeless persons;Inflammatory;Insulin Resistance;Island;Link;Liver;Liver Cirrhosis;liver development;Liver diseases;Liver Dysfunction;low socioeconomic status;Measurement;Measures;medical schools;Metabolic dysfunction;Native Hawaiian or Other Pacific Islander;Native-Born;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Obesity;Participant;patient population;Patients;Persons;Pilot Projects;point of care;point of care testing;Population;Population Heterogeneity;portability;Prevalence;Preventive measure;Primary carcinoma of the liver cells;Primary Care;primary care clinic;primary care setting;Public Health;Rest;Risk Factors;Rural;rural area;Rural Community;Rural Population;Sample Size;Sampling;screening;Site;social health determinants;standard of care;Techniques;ultrasound;Underinsured;Uninsured;urban area;Urban Community

PROJECT_TITLE: HAWAII CLINICAL RESEARCH NETWORK FOR HEALTH EQUITY


NIH_SPENDING_CATS: Digestive Diseases;Endocrine Disruptors;Genetics;Human Genome;Liver Disease;Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: IRVINE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Obesity is a major public health problem. We propose to elucidate how maternal and early life exposure to obesogens interacts with diet leading to increased obesity on a Western-style diet and resistance to fat loss during fasting. The successful completion of this research will make important contributions to understanding the developmental programming of obesity, how obesogens affect this process, and the interactions between diet and obesogen exposure on energy balance.

PI_NAMEs: BLUMBERG, BRUCE  (contact);SHIODA, TOSHIHIRO

PROGRAM_OFFICER_NAME: SCHUG, THADDEUS

PROJECT_TERMS: Address;Adipocytes;Adipose tissue;Adult;Affect;Age;Animals;ATAC-seq;Award;Basal metabolic rate;Black Populations;Blood;Blood Glucose;Body mass index;Cardiovascular Diseases;Cell Compartmentation;Cell Count;cell type;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;Clinical;Clinical Management;combat;Desire for food;Development;Diabetes Mellitus;Diet;diet and exercise;Dietary Fats;Dietary Practices;dieting;Disease;DNA;DNA Methylation;early life exposure;Endocrine Disruptors;Endocrine system;energy balance;Energy Intake;Energy Metabolism;Environment;Environmental Risk Factor;epigenome;epigenomics;Exhibits;experimental study;exposed human population;Exposure to;falls;Fasting;Fatty acid glycerol esters;Female;Generations;Genes;Germ Lines;Health;Health Care Costs;Hi-C;High Fat Diet;Hispanic;Hispanic Populations;hormone regulation;Human;Hypertension;in vivo;Individual;insight;Knowledge;Lead;Leisures;Leptin;Link;Lipids;Liver;male;Malignant Neoplasms;Mediating;Mesenchymal Stem Cells;Metabolic;Metabolism;Modeling;Molecular;mRNA Expression;multiple omics;Mus;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;Obese Mice;Obesity;Obesity Epidemic;obesity management;obesogen;obesogenic;offspring;Patients;Persons;Phenotype;Physical activity;Plasma;Predisposition;pregnant;prenatal;prenatal exposure;prevent;Preventive;Process;Public Health;Research;Resistance;Rodent;Role;Satiation;Signal Transduction;sperm cell;Testing;Testis;Therapeutic;Thinking;Time;Tissues;transcriptome;transcriptome sequencing;tributyltin;Weight;Weight Gain;western diet;Woman;Xenobiotics;Youth

PROJECT_TITLE: Interactions between prenatal obesogen exposure and Total Western diet lead to a transgenerational thrifty phenotype: functional and epigenomic analysis of effects in fat and liver

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


ADMINISTERING_IC: NS

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: In accordance with NINDS scientific goals to “understand the basic mechanisms of neurological disorders”, and “to discover and validate biomarkers and outcome measures”, the proposed work will advance the understanding of the neurobiological basis for poststroke spasticity and provide quantitative neuroimaging biomarkers to be used as outcome measures in clinical trials. This research will solve an urgent public health need to provide a more complete understanding of the neural mechanisms of poststroke spasticity by characterizing the functions of major descending and ascending circuits in relation to spastic hypertonia and hyperreflexia.

PI_NAMEs: VAHDAT, SHAHABEDDIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: The function of descending and ascending pathways in spastic hypertonia and hyperreflexia after stroke

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetics;Human Genome;Liver Disease;Precision Medicine;Substance Misuse

ORG_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

PI_NAMEs: LOHOFF, FALK  (contact)

PROJECT_TERMS: accelerated epigenetic aging;Acetaldehyde;Acetylation;Acute;Address;Affect;Age;age acceleration;Age Years;Aging;aging biomarker;aging process;Alcohol consumption;alcohol exposure;alcohol misuse;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholic liver damage;Alcoholic Liver Diseases;Alcohols;Algorithms;Animal Model;Area;Attenuated;Behavior;Biological;biological age;Biological Markers;Blood Cells;Brain;Chronic;chronic alcohol ingestion;Chronology;Clinical;Clinical Research;cohort;comparison control;Complex;Conduct Clinical Trials;CpG dinucleotide;Data;Development;Disease;Disease Outcome;DNA Methylation;DNA methyltransferase inhibition;Double-Blind Method;endophenotype;Environment;Environmental Risk Factor;Enzymes;epigenetic clock;epigenetic marker;Epigenetic Process;epigenome;epigenome-wide association studies;epigenomics;Ethanol Metabolism;Family;FDA approved;Folic Acid;follow-up;Gender;Generations;Genes;Genetic;Genetic Heterogeneity;genetic risk factor;Genome;Genomic approach;Genomics;Goals;Health;Hepatic;hepatocellular injury;Heritability;histone methylation;Human;Individual;Inflammatory;inhibitor;Investigational Therapies;Lifestyle-related condition;Link;Literature;Liver diseases;liver inflammation;liver injury;Longevity;Medicine;Mendelian randomization;Methionine;methyl group;Methylation;Modeling;Modification;Molecular;mortality;multiple omics;Nature;Neurobiology;new therapeutic target;novel;novel strategies;novel therapeutics;Outcome;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;Phase;Phenotype;Placebo Control;pre-clinical;Pre-Clinical Model;Production;protein expression;Public Health;Randomized;Rattus;Reactive Oxygen Species;Relapse;Risk;Role;S-Adenosylhomocysteine;S-Adenosylmethionine;Safety;safety study;Sample Size;Sampling;Site;social;Stress;Study models;Target Populations;Therapeutic Studies;Tissues;Translational Research;Triglycerides;Validation;Work

PROJECT_TITLE: Clinical Genomics and Experimental Therapeutics


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cardiovascular;Endocannabinoid System Research;Neurosciences;Nutrition;Obesity;Substance Misuse

PI_NAMEs: KUNOS, GEORGE  (contact)

PROJECT_TERMS: Afferent Neurons;Alcohol consumption;alcohol craving;alcohol seeking behavior;alcohol use disorder;Alcohols;Anxiety;AVIL gene;Behavior Control;Behavioral;Brain;Cardiovascular Physiology;CB1 knockout;CB1 receptor antagonist;Cells;CNR1 gene;CNR2 gene;Coupled;Desire for food;disease model;drinking;drinking behavior;Emotional;Endocannabinoids;endogenous cannabinoid system;food craving;Gastrointestinal tract structure;Genetic Markers;Genotype;ghrelin;ghrelin receptor;GLP-I receptor;gut-brain axis;Hormones;interest;Laboratories;Ligands;Lipids;Location;Magnetic Resonance Imaging;Marijuana;Mediating;Mental Depression;Metabolic;Metabolic Diseases;Metabolic syndrome;Motivation;Mucous Membrane;Mus;Muscle;Mutant Strains Mice;NBPhox protein;neurobehavioral;Neurons;Nodose Ganglion;novel;obese person;Obesity;Pathology;Peripheral;permissiveness;Persons;Pharmaceutical Preparations;Phase Ib Clinical Trial;Physiological;Population;pre-clinical;preference;Psychological reinforcement;Publications;receptor;Reporting;Role;selective expression;Sensory;Signal Transduction;Smooth Muscle;Spinal Ganglia;Stomach;Therapeutic;therapeutic evaluation;Tissues;Treatment Efficacy

PROJECT_TITLE: Endocannabinoids and the Control Of Behavior and Cardiovascular Function


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

PI_NAMEs: LANE, CLIFFORD  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Anti-Retroviral Agents;Antibodies;Antibody Response;antiretroviral therapy;Bar Codes;Binding;Biological Markers;Blood;Case/Control Studies;CD4 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Survival;Cells;Cessation of life;Chronic;Coagulation Process;cohort;Congenital Abnormality;Data;Detection;DNA;DNA Sequence Alteration;efavirenz;emtricitabine;Environment;experience;Failure;Fibrin fragment D;Fumarates;Genetic Transcription;Genome;genome sequencing;HIV;HIV Infections;HIV-1;HLA-DR Antigens;Homeostasis;immune activation;Immune response;Immune system;immunodeficiency;Immunologic Stimulation;immunological status;Immunologics;Immunosuppression;in vivo;Individual;Infection;Inflammation;inhibitor;innovation;Interleukin-6;Knowledge;Lamivudine;Ligands;Live Birth;low and middle-income countries;Measurement;Measures;nef Protein;novel;Nucleosides;Open Reading Frames;Participant;Pathogenesis;patient population;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Pharmaceutical Preparations;Phenotype;Positron-Emission Tomography;Pregnancy;Production;protein expression;Proteins;Proviruses;Randomized;Recovery;Resistance;Reverse Transcriptase Inhibitors;Risk;Ritonavir;RNA;RNA Viruses;Secondary to;Tenofovir;Thromboplastin;TNF gene;Transcript;Translations;treatment guidelines;Treatment Protocols;treatment strategy;Viral;Viral Proteins;Viremia;Virus;Virus Replication;Western Blotting

PROJECT_TITLE: Pathogenesis and Treatment of HIV Infection


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Anthrax;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Infectious Diseases;Lung;Maternal Health;Orthopoxviruses;Patient Safety;Pediatric;Pneumonia;Pneumonia and Influenza;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Women's Health Research

ORG_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

PROJECT_TERMS: 2019-nCoV;Acceleration;acute hypoxemic respiratory failure;Adult;Adverse event;adverse pregnancy outcome;Age;Anthrax Attack;Anthrax disease;Anti-viral Therapy;Antibiotics;Antibodies;Antigens;Area;Asian;Bacterial Pneumonia;biological heterogeneity;Biological Markers;biomarker identification;Birth;Black race;Blood;Blood Coagulation Disorders;C-reactive protein;Categories;Cessation of life;Characteristics;Child;Childhood;Clinical;Clinical Trials;cohort;community acquired pneumonia;Conduct Clinical Trials;COVID-19;COVID-19 patient;COVID-19 treatment;Data;Death Rate;Democratic Republic of the Congo;Diagnostic;Diarrhea;Disease;Disease Progression;Ebola;Ebola Hemorrhagic Fever;Ebola virus;Emerging Communicable Diseases;Endothelium;Enrollment;Enzyme-Linked Immunosorbent Assay;Epidemiology;epithelial injury;Evaluation;Event;Female;Fever;hazard;high risk;Hispanic;Hospitalization;Hypoxemic Respiratory Failure;IL8 gene;immunomodulatory therapies;improved;Individual;Indonesia;Infant;Infection;Inflammation;Inflammatory;Influenza;Inhalation;Injury;Institution;Interleukin-10;Interleukin-6;Investigational Therapies;Laboratories;long term consequences of COVID-19;long-term sequelae;Longitudinal Studies;Longterm Follow-up;Lung;Lymphocyte;Measurement;Measures;Methods;Modeling;Monkeypox;mortality;Mothers;Neuropeptides;neutrophil;new pandemic;novel strategies;Nucleocapsid;Nucleocapsid Proteins;Odds Ratio;Organ failure;Outcome;Outcome Study;Participant;participant enrollment;Pathogenesis;Patient Self-Report;Patients;Perinatal;Persons;placebo group;Placebos;Placenta;Plasma;Plasma Proteins;Pneumonia;Post-Acute Sequelae of SARS-CoV-2 Infection;Postpartum Period;predictive marker;Predictive Value;Pregnancy;Pregnancy Outcome;Prevention;procalcitonin;protein biomarkers;randomized placebo controlled trial;Randomized, Controlled Trials;Recovery;remdesivir;Reporting;Research;Respiratory Tract Infections;response;Risk;RNA;Role;Safety;safety outcomes;Sampling;SARS-CoV-2 infection;Seasons;Sensitivity and Specificity;Serious Adverse Event;seropositive;Severe Acute Respiratory Syndrome;severe COVID-19;Severity of illness;soluble RAGE;supplemental oxygen;Survivors;Temperature;Therapeutic Intervention;Thrombomodulin;treatment effect;treatment response;Umbilical Cord Blood;Upper respiratory tract;Vaccines;Viral;Viral Antigens;Viral Pneumonia;viral RNA;Virus Diseases;volunteer;White Blood Cell Count procedure

PROJECT_TITLE: Pathogenesis, Treatment and Prevention of Emerging Infectious Diseases


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rare Diseases

PI_NAMEs: SNELLER, MICHAEL C (contact)

PROJECT_TERMS: 2019-nCoV;Acute;acute COVID-19;acute infection;Acute Respiratory Distress Syndrome;Adult;Antibodies;Antibody Response;Cardiopulmonary;cell mediated immune response;Cessation of life;Characteristics;Clinical;cognitive function;cohort;Control Groups;COVID-19;COVID-19 sequelae;Data Analyses;Data Collection;design;Disease;Enrollment;Evaluation;Evolution;follow-up;Future;Health Status;Household;Immune response;Immunity;Incidence;Infection;Internal Medicine;Laboratories;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Mediating;Medical;Mental Health;Natural History;pandemic disease;Participant;Patients;Peripheral Blood Mononuclear Cell;persistent symptom;Persons;Physical Examination;Plasma;Pneumonia;post-COVID-19;Publishing;Questionnaires;Recording of previous events;Recovery;recruit;Reporting;Resolution;Respiratory Failure;response;Risk Factors;Sampling;SARS-CoV-2 immunity;SARS-CoV-2 infection;Serology;Serum;Severe Acute Respiratory Syndrome;Severities;Severity of illness;Survivors;Symptoms;T-Lymphocyte;Testing;Time;Trauma;Virus;Virus Diseases

PROJECT_TITLE: A Longitudinal Study of COVID-19 Sequelae and Immunity


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Colorectal Cancer;Congenital Structural Anomalies;Digestive Diseases;Genetics;Human Genome;Pediatric;Prevention;Rare Diseases

PI_NAMEs: O'SHEA, JOHN  (contact)

PROJECT_TERMS: Acceleration;Architecture;Autoimmune Diseases;B-Lymphocytes;Binding;Biological Assay;Bromodomain;Bruck-de Lange syndrome;cancer cell;Cell Aging;Cell Cycle Regulation;Cell Proliferation;cell type;Cells;Chemoresistance;chemotherapeutic agent;chemotherapy;Chromatin;Chromosome Structures;cohesin;Colon Carcinoma;Communication;comparative genomics;Complex;Confocal Microscopy;Coupled;CRISPR/Cas technology;Cryoelectron Microscopy;Data;Data Set;Defect;Development;Disease;DNA;DNA Damage;DNA Repair;Double Strand Break Repair;Doxorubicin;Drosophila genus;Drug resistance;Elements;Enhancers;Etiology;Eukaryota;Event;Evolution;Exhibits;Fluorescence-Activated Cell Sorting;FOXO1A gene;Frequencies;Future;Gene Expression;Gene Expression Regulation;gene network;Generations;Genes;Genetic Diseases;Genetic Recombination;Genetic Screening;Genetic Transcription;Genome;genome-wide;Genomic Instability;Genomics;Glycogen Synthase Kinase 3;Host Defense;Human;Human Genome;Immune;Immune Response Genes;Immune System Diseases;immunopathology;inhibitor;insight;interest;Interferon alpha;interferon-stimulated gene factor 3;Interferons;Label;Length;lymphoblastoid cell line;Lymphoma;Malignant Neoplasms;Mammalian Cell;Mass Spectrum Analysis;mathematical model;Mediating;Mediator;Messenger RNA;Microscopy;Molecular;Molecular Target;mouse genome;mouse model;Mus;neural network;Nonhomologous DNA End Joining;novel;Nuclear;Organism;Pathway Analysis;Patients;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;Population;prevent;Process;Prognostic Marker;promoter;Protein Complex Subunit;Proteins;Proteome;Reaction;Regulator Genes;Regulatory Element;residence;Resistance;Resolution;response;RNA Binding;RNA Polymerase II;Role;Screening Result;Signal Transduction;single molecule;single-cell RNA sequencing;Sirolimus;Stimulus;Structure;Structure of germinal center of lymph node;System;Technology;temporal measurement;Time;Tissue-Specific Gene Expression;Tissues;tool;Transcription Coactivator;transcription factor;Transcription Initiation;Transcriptional Regulation;transcriptome;transcriptomic profiling;transcriptomics;treatment response;ubiquitin-protein ligase;Up-Regulation;Work

PROJECT_TITLE: Mechanisms of gene expression and recombination


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Hematology;Pediatric;Rare Diseases;Rheumatoid Arthritis

PI_NAMEs: OMBRELLO, MICHAEL  (contact)

PROJECT_TERMS: 16 year old;Address;Adult;Adult-Onset Still's Disease;Affect;Age of Onset;Algorithms;Alleles;Arthritis;Atherosclerosis;Atherosclerosis Risk in Communities;Autoimmunity;autoinflammation;autoinflammatory;autoinflammatory diseases;autosome;B-Cell Antigen Receptor;Biochemical;Bioinformatics;Biology;boys;case control;Cell Line;Cells;Child;Childhood;Chronic;Chronic Childhood Arthritis;CHS1 gene;Clinical;Clinical Immunology;Code;cohort;Collaborations;Collection;Complex;Custom;Cytoplasmic Granules;Data;database of Genotypes and Phenotypes;Daughter;Development;Disease;Dominant-Negative Mutation;Drug Exposure;Environmental Risk Factor;Eosinophilia;Etiology;Exanthema;exome sequencing;experience;familial hemophagocytic lymphohistiocytosis;Family;Fathers;Fever;Frequencies;Functional disorder;Genes;Genetic;genetic risk factor;Genetic study;genetic variant;Genomics;girls;Goals;Hemophagocytic Lymphohistiocytoses;Hereditary Periodic Fever Syndromes;Herpesviridae Infections;Heterogeneity;Heterozygote;HLA-DRB1;Human;humoral immunity deficiency;Hypersensitivity;IL-6 inhibitor;Immune;immune activation;immunodeficiency;improved;improved outcome;in silico;In Vitro;Individual;Infection;Inflammation;Inflammatory;Inflammatory Arthritis;Interleukin-1;Interleukin-6;International;Intramural Research;Investigation;Joints;Journals;Lesion;Life;loss of function;Loss of Heterozygosity;Lung;Lung Diseases;lymphoid hyperplasia;Macrophage activation syndrome;Manuscripts;Mediating;Medicine;Mendelian disorder;Morbidity - disease rate;mortality;Mutation;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Killer Cells;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Paper;Pathogenesis;Pathway interactions;patient subsets;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Phenotype;Phospholipases A;Phosphorylation;PLCG2 gene;Population;Population Control;predictive marker;Predisposition;Prevalence;Proteins;Protocols documentation;prototype;Publishing;rare variant;Reaction;Recommendation;recruit;Refractory;release of sequestered calcium ion into cytoplasm;Reporting;Resolution;Resources;Rheumatology;risk variant;Role;Salmon;Serositis;skin color;Source;Symptoms;Syndrome;systemic juvenile idiopathic arthritis;Technology;Testing;therapy outcome;transcriptomics;Translational Research;United States National Institutes of Health;Urticaria;Variant;Work

PROJECT_TITLE: Genetics and pathophysiology of systemic juvenile idiopathic arthritis and other complex autoinflammatory diseases


NIH_SPENDING_CATS: Arthritis;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Genetics;Human Genome;Lupus;Rheumatoid Arthritis

PI_NAMEs: KAPLAN, MARIANA  (contact)

PROJECT_TERMS: Abnormal Neutrophil;Acceleration;Address;Adult;Affect;Apoptosis;Area;arthropathies;ATAC-seq;Atherosclerosis;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Binding;Biological Assay;Biology;Blood Proteins;Blood Vessels;bone;cardiovascular disorder risk;Cells;Cessation of life;Chromatin;clinical center;Clinical Trials;Coronary Arteriosclerosis;cytokine;Cytoplasmic Protein;Development;Disease;Endothelial Cells;Etiology;Event;extracellular;Female of child bearing age;Functional disorder;Future;Gene Expression;Generations;genetic signature;Goals;Health;Heterogeneity;human model;Image;Immune;Impairment;Inflammatory;innate immune pathways;interest;Interferon Type I;Intervention;Investigation;Lead;Lupus;Mediating;Molecular;mouse model;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural History;Natural Immunity;neutrophil;Organ;organ growth;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Periodontitis;pharmacologic;Post-Translational Protein Processing;premature;Process;repaired;Reporting;Research Personnel;Rheumatism;Rheumatoid Arthritis;Risk;Risk Factors;Role;Sex Differences;single-cell RNA sequencing;Structure;Syndrome;systemic autoimmune disease;systemic autoimmunity;Systemic disease;Systemic Lupus Erythematosus;Techniques;Thromboplastin;thrombotic;Tissues;transcriptome sequencing;Vascular Diseases;Vasomotor;Work

PROJECT_TITLE: Systemic Autoimmunity


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Human Genome;Lupus;Patient Safety

PI_NAMEs: FRANCO, LUIS  (contact)

PROJECT_TERMS: Anti-Inflammatory Agents;Autoimmune Diseases;Cell Line;cell type;Cells;Clinical;clinical practice;Clinical Research;Clinical Trials Data Monitoring Committees;cohort;COVID-19 pandemic;Data;Data Analyses;Development;Dose;functional genomics;Generations;Genomics;Glucocorticoids;Goals;Human;Immune;Immune system;Knowledge;Laboratories;Methylprednisolone;Participant;Patients;preclinical study;Protocols documentation;recruit;Rodent Model;sample collection;Sampling;Serious Adverse Event;side effect;System;Systemic Lupus Erythematosus;targeted treatment;Therapeutic Intervention

PROJECT_TITLE: Genomic Effects of Glucocorticoids in Patients with Systemic Lupus Erythematosus


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Vaccine Related

PI_NAMEs: SCHUCK, PETER  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Algorithmic Analysis;analytical ultracentrifugation;Artificial Intelligence;Biological Products;Biotechnology;Calibration;Chemicals;Communication;Complex;Computational algorithm;Computer software;Cytosol;Data;Data Analyses;design;Detection;Development;Diffusion;Documentation;Drug Delivery Systems;Ensure;Environment;Equilibrium;Exhibits;Expert Systems;Formulation;Future;gene therapy;Goals;Immunoglobulin G;Laboratories;lens;light scattering;lipid nanoparticle;Lipids;Liquid substance;macromolecular assembly;Macromolecular Complexes;Malignant Neoplasms;Manufacturer;manufacturing run;Measurement;Measures;Mechanics;Methods;Modeling;Morphologic artifacts;Multiprotein Complexes;nano;nanomedicine;nanoparticle;Nature;Noise;novel strategies;Optics;Particle Size;Pattern;Peer Review;Preparation;Process;Production;Protein Dynamics;Proteins;prototype;Publications;Publishing;Quality Control;Radial;Reaction;Reporting;Research;Resolution;RNA vaccine;Sampling;sedimentation coefficient;Sedimentation process;sedimentation velocity;Serum Albumin;Serum Proteins;Standardization;Techniques;Testing;Therapeutic;therapeutic protein;Time;tool;Update;Vaccine Therapy;Vaccines;Viral;Viral Vector;Work

PROJECT_TITLE: Dynamics of Protein Assemblies by Analytical Ultracentrifugation


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Networking and Information Technology R&D (NITRD)

ORG_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PI_NAMEs: PIERPAOLI, CARLO  (contact)

PROJECT_TERMS: Algorithms;analysis pipeline;Atlases;base;Biological;Brain;Cardiac;Clinical;Computer software;Data;data quality;denoising;Diffusion;Diffusion Magnetic Resonance Imaging;Dropout;Echo-Planar Imaging;elastography;empowerment;Ensure;Goals;Image;image registration;improved;Individual;Magnetic Resonance Imaging;Maps;Mathematics;Methods;Modeling;Morphologic artifacts;Morphology;Motion;novel;Phase;Picture Archiving and Communication System;Population;Population Study;prevent;Process;processing speed;Programming Languages;Property;Recording of previous events;Reproducibility;Research Personnel;Series;Signal Transduction;System;Time;Translating;Turtles;Update;user friendly software

PROJECT_TITLE: Processing and Analysis of Quantitative Diffusion MRI Data


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Clinical Research;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

PI_NAMEs: SADTLER, KAITLYN  (contact)

PROJECT_TERMS: 2019-nCoV;Autoimmune;Autoimmune Responses;Autoimmunity;Biocompatible Materials;cell type;Collaborations;Collagen;Communities;COVID-19;Data;Deposition;eosinophil;Family suidae;Fibrosis;Foreign Bodies;Human;Immune;Immune response;immunoengineering;Immunology;implantation;In Vitro;Injury;Journals;Link;Literature;Location;Manuscripts;Metabolism;Methods;Modeling;mouse model;MRL/MpJ Mouse;Mus;Muscle;Natural regeneration;Nature;Paper;Pathway interactions;Process;Publications;Publishing;Reporting;Research;Research Project Grants;response;Role;Shapes;tissue regeneration;Tissues;Trauma;trauma centers;Traumatic injury;United States National Institutes of Health;Work;wound healing;Wound models

PROJECT_TITLE: Immunoengineering


NIH_SPENDING_CATS: Bioengineering;Cancer;Digestive Diseases;Nanotechnology;Ovarian Cancer;Pancreatic Cancer;Rare Diseases;Women's Health Research

PI_NAMEs: CARTAGENA-RIVERA, ALEXANDER  (contact)

PROJECT_TERMS: 3-Dimensional;Actins;Actomyosin;Anisotropy;Antibodies;Antigen-Presenting Cells;Antigens;Architecture;Atlas of Cancer Mortality in the United States;Atomic Force Microscopy;Behavior;Biological;Biology;Biomechanics;biophysical techniques;biophysical tools;Biophysics;Cancer Biology;cancer cell;Cancer cell line;Cancer Detection;cancer therapy;Cancerous;cantilever;Cause of Death;CD28 Antigens;CD3 Antigens;Cell membrane;Cell Nucleus;Cell Physiology;cell type;Cells;Cellular biology;cellular development;Cellular Structures;Characteristics;Chemicals;Communities;Complex;complex biological systems;Cytoskeleton;deafness;Development;Developmental Biology;Diagnosis;Dimensions;Disease;Disease Progression;Dissection;Distal;Dorsal;Elasticity;Engineering;Epithelium;ERM protein;Extracellular Matrix;F-Actin;fluorescence microscope;Gel;Generations;genetic regulatory protein;Glycocalyx;Goals;Growth;Hearing;Heterogeneity;Hydrostatic Pressure;Image Analysis;Immune;immune activation;immunological synapse;immunological synapse formation;Individual;Inflammation;Integrins;Knowledge;Laboratories;Labyrinth;Liquid substance;Lymphocyte;macromolecular assembly;Maintenance;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;materials science;mathematical model;Mathematics;Measures;mechanical force;mechanical properties;Mechanics;mechanotransduction;Mediator;Metastatic Malignant Neoplasm to the Ovary;Methods;Microscopy;Microtubules;migration;Modulus;Molecular;molecular mechanics;Monitor;mortality;Motility;multidisciplinary;Myosin Type II;nanomechanics;nanoscale;National Institute of Biomedical Imaging and Bioengineering;Neoplasm Metastasis;neoplastic cell;non-muscle myosin;novel;novel strategies;novel therapeutic intervention;Optics;Organelles;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;Pathology;Patients;Physics;Physiological;Play;Polymers;Positioning Attribute;post-doctoral training;Postbaccalaureate;Postdoctoral Fellow;pressure;Process;Prognosis;Proliferating;Property;Regulation;Research;Resolution;response;Role;Sampling;self organization;Sensory;Side;Site;Solid Neoplasm;spatiotemporal;Spectrum Analysis;Stress;surface coating;Surface Tension;Surveys;Survival Rate;T-Lymphocyte;Techniques;Therapeutic;Tissues;tool;Traction;Traction Force Microscopy;trait;transmission process;Tumor Markers;tumor microenvironment;tumor progression;ultra high resolution;viscoelasticity;Viscosity

PROJECT_TITLE: Mechanobiology