NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research

PI_NAMEs: YOPP, ADAM  (contact)

PROJECT_TERMS: Academia;Animal Model;Asian;biobank;Biological Markers;Black race;Bladder;Blood;Blood specimen;Body Fluids;Bone Marrow;Breast;cancer cell;Cancer Center Support Grant;Cell Culture Techniques;Cell Line;Cells;Center for Translational Science Activities;Clinical;Clinical Data;Collaborations;Colon;Comprehensive Cancer Center;Computerized Medical Record;Consent;Consultations;Cryopreserved Tissue;Custom;Data;Databases;Dedications;DNA;Evaluation;Feedback;Female;Formalin;Freezing;Funding;Genomics;Goals;Grant;Hispanic;Histology;Human;human model;Image Analysis;Immunohistochemistry;Immunology;Industry;Infrastructure;innovation;insight;Intranet;Journals;Kidney;Leadership;Liquid substance;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Medical center;Medicine;Melanoma;member;Methodology;Molecular;Mus;National Cancer Institute;Nature;NCI Center for Cancer Research;Normal tissue morphology;Not Hispanic or Latino;Online Systems;Pancreas;Participant;Pathologic;Pathologist;Pathology;Peer Review;Plasma;Pleural;preservation;Primary carcinoma of the liver cells;Principal Investigator;programs;prospective;Prostate;Publications;Publishing;Quality Control;Renal Carcinoma;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;RNA;Sampling;Science;searchable database;Serum;Services;Signal Transduction;Specialized Program of Research Excellence;Specimen;Stomach;success;Surveys;Time;Tissue Banks;tissue fixing;Tissue Microarray;Tissue Procurements;Tissues;tumor;Tumor Cell Line;tumor registry;Tumor Tissue;Urine;web interface;web portal;whole slide imaging;Work

PROJECT_TITLE: Tissue Management Shared Resource


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ROCHESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHARMACOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Piezo1 mechanically-activated Ca2+ channels play critical roles in cellular mechanosensitivity, and Piezo1-me- diated mechanotransduction is implicated in various human health and disease. Previous research and our preliminary data suggest a previously unappreciated role of Piezo1 in regulating cellular morphology and mechanosensitivity under inflammatory conditions. We will use cutting-edge engineering and physiology ap- proaches to identify fundamental mechanisms of Piezo1-dependent mechanotransduction-inflammation coupling using chondrocytes as a model system.

PI_NAMEs: LEE, WHASIL  (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Biochemical;Biological Models;Cardiovascular system;Cartilage Diseases;Cells;Cellular Morphology;Cessation of life;Chondrocytes;Coupling;Custom;cytokine;Cytoskeletal Modeling;Data;Degenerative polyarthritis;Diameter;Disease;Engineering;Exhibits;F-Actin;Fatigue;Fibroblasts;Health;Human;Inflammation;Inflammatory;Inflammatory Response;insight;Ion Channel;Ions;Knowledge;Mammalian Cell;mechanical signal;mechanical stimulus;Mechanics;mechanotransduction;Mediating;Membrane;Methods;Microfilaments;Microscope;microscopic imaging;Microscopy;Morphology;Mus;Musculoskeletal;Names;neural;novel;novel therapeutic intervention;patch clamp;Physiological Processes;Physiology;Piezo 1 ion channel;Play;prevent;Process;programs;Property;ratiometric;recruit;Reporter;Research;response;Role;Scanning Probe Microscopes;seal;Shapes;Signal Transduction;Speed;Tissues;ultra high resolution;virtual

PROJECT_TITLE: Mechanotransduction-inflammation coupling: Piezo1-dependent cellular morphology changes in disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-L(55)R]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Dietary Supplements;Digestive Diseases;Microbiome;Nutrition;Prevention

ORG_CITY: BOSTON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: PROJECT NARRATIVE This project seeks to interrogate the interplay between diet, the gut microbiome-derived secondary bile acids, and colorectal cancer risk by conducting an observation study in four large prospective cohorts and a single-arm pilot clinical trial. The proposed research will enable unprecedented perspectives on how the gut microbial metabolism of bile acids mediates the dietary influence on colorectal cancer development and provide compelling data to develop a bile acid/gut microbiome axis-targeted diet for the prevention of colorectal cancer.

PI_NAMEs: WANG, KAI  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Adherence;Alcohols;Alkaline Phosphatase;American;Animals;Apoptosis;Area;arm;bacterial community;Bifidobacterium;Bile Acid Biosynthesis Pathway;bile acid metabolism;Bile Acids;Bioinformatics;Biological;Biological Markers;Biological Sciences;Blood;Calories;cancer diagnosis;cancer prevention;cancer subtypes;Carbohydrates;cardiometabolic risk;career;career development;CD3 Antigens;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maturation;Cells;Cessation of life;Clinical;clinical epidemiology;Clinical Trials;Coffee;cohort;Cohort Studies;Colon;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Communities;Consumption;cruciferous vegetable;Data;Dendritic Cells;Deoxycholic Acid;design;Development;Diet;diet and cancer;Diet Records;dietary;Dietary Fiber;Dietary Intervention;Dietary Practices;Environment;Epidemiology;epidemiology study;Escherichia coli;ethnic diversity;Etiology;Excision;Fatty acid glycerol esters;Feces;Follow-Up Studies;Food;food consumption;Foundations;FOXP3 gene;Fusobacterium nucleatum;Future;Gene Expression;Gene Expression Profile;Genes;Goals;good diet;gut microbes;gut microbiome;gut microbiota;Health Professional;Human;Immune;improved;indexing;Inflammation;innovation;Intake;Intervention;Intervention Studies;Intestines;Life;Link;Lithocholic Acid;Liver;Malignant Neoplasms;Measures;mecysteine;Mediating;Mediator;Mentors;Mentorship;Metabolic;metabolomics;Methods;Microbe;microbial;multidisciplinary;Nurses' Health Study;Nutrient;nutrition;Nutritional;nutritional epidemiology;Nuts;Observational Study;Olive oil preparation;oxidative DNA damage;Pathway interactions;Patients;Plants;Play;Population Heterogeneity;Potato;Prevention;Preventive;Processed Meats;Production;programmed cell death protein 1;programs;Property;prospective;Prospective cohort;Proteins;PTPRC gene;racial diversity;Reducing diet;Reporting;Research;Research Personnel;Resistance;response;Risk;Risk Factors;Role;Scientist;Secondary to;Sulfoxide;T cell response;Tea;Testing;Time;Tissue Banks;Tomatoes;Training;treatment arm;tumor;tumorigenic;western diet

PROJECT_TITLE: Dietary prevention for colorectal cancer: targeting the bile acid/gut microbiome axis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

ORG_STATE: PA

PHR: NARRATIVE Systemic lupus erythematosus (SLE) is a heritable autoimmune disease that primarily affects young females. Genome-wide association studies have identified >190 loci associated with SLE but the genetic architecture remains elusive. Expanding the analysis to diverse human populations will further empower discovery, elucidate causal variants, and improve diagnosis and risk predictions, all of which have strong public health relevance.

PI_NAMEs: CARREL, LAURA ;LIU, DAJIANG  (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;Affect;Antinuclear Antibodies;Autoimmune Diseases;Biological Assay;causal model;causal variant;Clinical;Complement;Computer software;cost effective;Data;data integration;Data Set;Diagnosis;Disease;Disease Progression;disorder risk;Early Diagnosis;Early treatment;empowerment;Enhancers;Environmental Exposure;Etiology;European ancestry;Exanthema;experimental study;Feedback;Female;Frequencies;Gene Frequency;Genetic;genetic architecture;Genetic Heterogeneity;Genetic Models;Genetic Risk;Genetic study;genetic variant;genome wide association study;genome-wide;Genotype;Heritability;Heterogeneity;Human;improved;Individual;interest;Linkage Disequilibrium;Logistics;Lupus;Maps;Meta-Analysis;method development;Methods;Modeling;multiple datasets;Multiple Organ Failure;Organ;Phenotype;Population;prevent;public health relevance;Quality of life;Reporter;Research;risk prediction;Signal Transduction;simulation;Statistical Methods;statistics;success;Symptoms;Systemic Lupus Erythematosus;Testing;trait;Validation;Variant

PROJECT_TITLE: Integrative approaches to understand systemic lupus erythematosus etiology in trans-ancestry genetic studies

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Digestive Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE This is a competitive renewal application for years 25-30 of a program to train postdoctoral investigators in basic and translational gastrointestinal research. Our T32 program’s primary goal is to develop future academic and scientific leaders of gastroenterology research by training promising MD, MD/PhD, DVM, DVM/PhD and PhD postdoctoral scientists to become independent laboratory-based and translational investigators focused on clinically relevant gastrointestinal research topics. Our training program has a robust pipeline of highly qualified applicants who undergo comprehensive interdisciplinary research training and career development that prepares them well for sustained, impactful independent research careers.

PI_NAMEs: SHEIKH, SHEHZAD Z. (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Gastroenterology;Research Training

PROJECT_TITLE: Gastroenterology Research Training


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Neurosciences

ORG_CITY: PROVIDENCE

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE Cognitive control, also termed executive function, allows us plan, organize, and direct our thoughts and actions toward goals. A wide range of neurological and psychiatric conditions exhibit deficits in cognitive control, which devastates employment, scholastic achievement, and independence. The proposed fundamental research, that focuses on how the human brain represents the many combinations of task elements separately for control may eventually promote clinical applications that refine diagnosis and improve rehabilitation.

PI_NAMEs: BADRE, DAVID  (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Achievement;Animal Model;Area;Behavior;Behavioral;Brain;Brain region;clinical application;Code;cognitive control;Consensus;Data;Diagnosis;Dimensions;Electroencephalography;Elements;Employment;executive function;Exhibits;experimental study;flexibility;functional magnetic resonance imaging/electroencephalography;fundamental research;Geometry;Goals;high dimensionality;Human;improved;information organization;Link;Maps;Methodology;Methods;multitask;National Institute of Neurological Disorders and Stroke;Nature;neural;Neurologic;Neurons;Neurosciences;novel;Pattern;Performance;Population;Prefrontal Cortex;programs;Property;Rehabilitation therapy;Research;Resolution;response;Short-Term Memory;Testing;theories;Thinking

PROJECT_TITLE: The organization of neural representations for flexible behavior in the human brain


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: PORTLAND

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Optical coherence tomography (OCT) is a high-resolution imaging technology that is already commonly used to diagnose and monitor glaucoma, a leading cause of blindness. The proposed research will further improve this technology so that it can detect earlier stages of glaucoma, evaluate the location and severity of glaucoma damage, and provide more accurate monitoring of disease progression. Directional OCT technology will be developed to accurately measure nerve fiber layer reflectance; sensorless adaptive-optics OCT technology will be used to improve imaging of nerve fiber bundles and capillaries; ultrahigh axial resolution will enable imaging of detailed internal retinal structures such as the lamellae of the inner plexiform layer; and capillary perfusion measurements will be used to simulate visual field function.

PI_NAMEs: HUANG, DAVID  (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: 3-Dimensional;accurate diagnosis;adaptive optics;Angiography;Blindness;Blood capillaries;Clinical;clinical practice;Clinical Research;Data;deep neural network;Defect;Detection;detection sensitivity;Diagnosis;Diagnostic;diagnostic strategy;Disease;Disease Progression;Early Diagnosis;Ensure;Evaluation;field study;Floor;Future;Ganglion Cell Layer;Glaucoma;Goals;Grant;high resolution imaging;high risk;Image;Imaging technology;improved;Incidence;Inner Plexiform Layer;Intervention;Lasers;Location;macula;Maps;Measurement;Measures;Medical;Methods;Monitor;Nerve Fibers;new technology;next generation;Nose;novel;novel strategies;Open-Angle Glaucoma;Operative Surgical Procedures;Optic Disk;optic nerve disorder;Optical Coherence Tomography;Papillary;Patients;Pattern;Performance;Perfusion;prevent;progression risk;prototype;quantitative imaging;Questionnaires;Real-Time Systems;Reproducibility;Research;Resolution;Retina;Scanning;Severities;Severity of illness;simulation;Speed;Structure;System;Techniques;Technology;Testing;Thick;Time;tool;Variant;Vision;Visual Fields;Visualization

PROJECT_TITLE: Functional and Structural Optical Coherence Tomography for Glaucoma


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research

ORG_CITY: GAINESVILLE

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE This study will be the first observational, longitudinal study to measure and compare over time biochemical measures in the circulation and skeletal muscle related to iron deregulation and mitochondrial dysfunction in both low-functioning and high-functioning older adults. The results from this study will help to identify cellular targets for future studies to improve iron homeostasis and mitochondrial function, which should ultimately slow the rate of progression of functional decline in older adults.

PI_NAMEs: ANTON, STEPHEN D;LEEUWENBURGH, CHRISTIAAN  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Affect;Age;Aging;animal old age;Binding;Biochemical;Biological;Blood;Cell Aging;Cell Physiology;cellular targeting;Circulation;Classification;Clinical;Clinical Trials Design;Code;Data;Dietary intake;DNA strand break;Electron Transport;Epigenetic Process;Etiology;follow-up;Fostering;frataxin;functional decline;Future;Genomic Instability;Goals;hallmarks of aging;Health behavior;healthy aging;hepcidin;Homeostasis;Hormones;Human;human old age (65+);Impairment;improved;Individual;Intervention;Iron;Link;Longitudinal, observational study;longitudinal, prospective study;Measures;metal transporting protein 1;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial permeability transition pore;Mobility disability;Molecular;mortality;Movement;Muscle;Muscle Fibers;Muscle Mitochondria;muscle strength;Mutation;National Institute on Aging;novel therapeutics;Nutrient;older adult;oxidative damage;Oxidative Stress;Participant;Performance;Permeability;pharmacologic;Physical assessment;Physical Function;Physical Performance;physically handicapped;Pilot Projects;Plasma;Play;pre-clinical;Predisposition;preservation;prevent;Process;Production;Prospective Studies;Protein Export Pathway;protein expression;Protein Import;Proteins;proteostasis loss;public health priorities;Regulation;Research;resilience;Respiration;Role;Signal Transduction;skeletal disorder;Skeletal Muscle;Sleep;standard measure;stem cell exhaustion;Strategic Planning;targeted treatment;Telomere Shortening;Testing;TFRC gene;Time;United States National Institutes of Health;Visit;Walking;walking performance;walking speed;Work

PROJECT_TITLE: Functional Decline in Low Functioning Older Adults; Role of iron dysregulation

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ORG_DEPT: OTHER BASIC SCIENCES

PHR: PROJECT NARRATIVE Gastrointestinal diseases caused by enteric viral pathogens impose a significant global health burden and can be lethal in vulnerable populations. Interferon lambda (IFN-λ) is a cytokine with particular importance in the antiviral immune response of intestinal epithelial cells, and is stimulated by the bacterial microbiota. Through the studies of this research project, we will identify the mechanism of microbiota-stimulated IFN-λ responses in intestinal epithelial cells, thereby advancing our understanding of antiviral immunity to enteric viral pathogens.

PI_NAMEs: NICE, TIMOTHY J. (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Agonist;antagonist;Anti-viral Response;antiviral immunity;Area;Bacteria;Bone Marrow;Cell Fraction;Cell Separation;Cells;Chimera organism;Clinical Pathways;clinically relevant;comparison group;cytokine;Data;Dendritic Cells;Development;Disease;Elements;Enteral;enteric virus infection;Epithelial Cells;experimental study;Exposure to;Family;Flagellin;Gastrointestinal Diseases;Gene Expression;Genes;Genetic;global health;Immune response;Inflammatory;Interferon Type I;Interferons;intestinal barrier;intestinal epithelium;Intestines;Knock-out;laser capture microdissection;Leukocytes;Lipopolysaccharides;microbiota;Modeling;Mus;Natural Immunity;neonatal mice;Norovirus;pathogenic virus;pharmacologic;Population;Production;PTPRC gene;Publishing;Receptor Signaling;Regulation;Research;Research Project Grants;Research Proposals;research study;response;Role;Rotavirus;Rotavirus Infections;Signal Transduction;single-cell RNA sequencing;Site;Sorting;Source;Stimulus;Testing;Tight Junctions;Tissues;Toll-like receptors;Viral;Viral Genes;Virus;Virus Diseases;Vulnerable Populations;Work

PROJECT_TITLE: Innate immunity to enteric virus infection by IFN-lambda stimulated-gene expression

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The survival of cancer cells after chemotherapy is a major barrier to clinical cures. Small cell lung carcinomas (SCLC) exhibit a general pattern of initial sensitivity to chemotherapy with almost invariable progression after treatment cessation. Herein, we show that SCLC tumors are highly adaptable to chemotherapy in large part because they undergo rapid cell state transitions. We posit that determining the form and function of SCLC's multi-faceted and mutable states will advance new therapeutic strategies in this recalcitrant disease.

PI_NAMEs: ABAZEED, MOHAMED E. (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Affect;Aftercare;Bar Codes;Behavior;Biodiversity;Biological;Biological Assay;Biological Models;cancer cell;cancer heterogeneity;cancer survival;cell behavior;Cell Communication;Cell model;cell type;Cells;Chemoresistance;Chemotaxis;chemotherapy;Clinical;Clinical Trials Design;clinically relevant;combat;Coupled;Cues;Cytoplasm;Data;discrete time;Disease;DNA Sequence Alteration;Ecosystem;Elasticity;Environment;epigenetic drug;Epigenetic Process;epigenome;Equilibrium;Equipment and supply inventories;Exhibits;experimental study;Exposure to;Extinction;Fluorescence;functional genomics;Gene Expression;Genetic;Genetic Transcription;Genome;Growth;Heterogeneity;Human;in vivo;Individual;innovation;insight;Invaded;Investigation;Kinetics;Malignant Epithelial Cell;Malignant Neoplasms;Markov Chains;mathematical model;Measurement;Measures;Membrane;Mesenchymal;Methods;Modeling;multiple omics;Mus;neural;Neuroendocrine Cell;Neuroendocrine Tumors;novel therapeutic intervention;novel therapeutics;Outcome;patient derived xenograft model;Patients;Pattern;Pharmacotherapy;Phenotype;Population;Population Dynamics;prevent;Primary Neoplasm;programs;rapid growth;Registries;Relapse;Reporter;Research Personnel;Resistance;Resources;response;Role;Sampling;single-cell RNA sequencing;small cell lung carcinoma;standard of care;Statistical Models;study population;System;Therapeutic;therapy design;therapy resistant;Time;transcription factor;Transcription Factor 3;translational model;treatment response;tumor;tumor heterogeneity;tumor initiation;Withholding Treatment

PROJECT_TITLE: Cellular plasticity gives rise to phenotypic equilibrium in small cell lung carcinoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: NARRATIVE We will develop, deploy, and disseminate new informatics technologies that leverage existing single-cell transcriptomic atlases to assist and automate the design and analyses of multiplexed antibody-based cytometry experiments in cancer research. These computational methods will be instrumental in ensuring standardized, scalable, and reproducible cytometry analyses of tumors with increased phenotypic resolution. By facilitating accurate characterizations of tumor cell ecosystems, our research will impact advances in cancer treatment.

PI_NAMEs: GONZALEZ CAMARA, PABLO  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Algorithms;anti-cancer research;Antibodies;Antigens;Atlases;Automated Annotation;Base Composition;Bioinformatics;cancer therapy;Cell Separation;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Characteristics;Cloud Computing;Collaborations;Collection;Communities;Computer software;Computing Methodologies;Cost efficiency;Cytometry;Data;Data Set;design;Ecosystem;Educational workshop;Ensure;experimental study;Flow Cytometry;fluorophore;Gene Expression Profile;Genes;Goals;Hematopoietic Neoplasms;Human;immune cell infiltrate;Immunohistochemistry;Informatics;Information Theory;Learning;learning algorithm;leukemia;Leukocytes;Malignant neoplasm of pancreas;Manuals;Maps;Measurement;Methods;Neoplasm Metastasis;neoplastic cell;Ontology;open source;outreach;Pathogenesis;Performance;Phenotype;Population;Process;Proteins;public repository;Publishing;relational database;repository;Reproducibility;Research;Research Personnel;Resolution;single-cell RNA sequencing;Standardization;Statistical Models;Technology;Testing;therapy resistant;Tissues;transcriptome;transcriptomics;tumor;tumor progression;Tumor Tissue;web portal;Work

PROJECT_TITLE: A data-driven bioinformatics platform for the design and analysis of multiplexed antibody-based cytometry experiments in cancer research


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: CINCINNATI

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Despite the remarkable progress in recent years, our knowledge about the mechanisms underlying breast cancer metastasis, which are ultimately responsible for patient lethality, is still limited. The characterization of molecular and cellular mechanisms at the intersection of key cellular processes, such as autophagy and vesicle trafficking in HER2+ breast cancer cells, will significantly advance our fundamental knowledge about breast cancer and contribute to novel therapies to eradicate this deadly disease.

PI_NAMEs: GUAN, JUN-LIN  (contact)

PROGRAM_OFFICER_NAME: BERA, TAPAN K

PROJECT_TERMS: Ablation;Accounting;Acetylation;Autophagocytosis;Bioinformatics;Breast Cancer Cell;breast cancer metastasis;Cell membrane;Cell model;Cell Physiology;Cells;combinatorial;conditional knockout;CRISPR screen;CRISPR/Cas technology;Custom;Cytoplasm;Data;design;Disease;driver mutation;effective therapy;efficacy evaluation;Endosomes;Epidermal Growth Factor Receptor;ERBB2 gene;Event;extracellular vesicles;Family;Functional disorder;Funding;Genes;genetic approach;Goals;Golgi Apparatus;Health;Hela Cells;Human;human disease;improved outcome;In Vitro;in vivo;Incidence;inhibition of autophagy;insight;Intervention;knock-down;Knock-in;Knock-out;Knowledge;Libraries;loss of function;Lysosomes;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammary Tumorigenesis;Maps;Mediating;member;Membrane Fusion;Modeling;Molecular;Mouse Mammary Tumor Virus;mouse model;Mus;mutant;Mutation;Neoplasm Metastasis;neoplastic cell;novel therapeutics;Oncogenic;patient responsibilities;Patients;pharmacologic;Phosphorylation;Proteins;Receptor Protein-Tyrosine Kinases;Recycling;Regulation;Regulator Genes;Relapse;Resistance;Role;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;small molecule inhibitor;synergism;targeted treatment;Therapeutic;therapy resistant;trafficking;Trastuzumab;Tyrosine Kinase Inhibitor;Vesicle;virtual;Woman

PROJECT_TITLE: Intersection of autophagy and vesicle trafficking in Her2-positive breast cancer

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative  Intravesical chemotherapy for bladder cancer is unreliable and limited by incomplete drug delivery and invasiveness. The goal of this project is to develop an urgently needed new approach that will improve outcomes with a novel combinatorial treatment that covers the entire urinary system, prolonging exposure of tumors to drugs, while using low-morbidity administration techniques.

PI_NAMEs: LAW, BENEDICT SHEK HANG (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: absorption;Affect;Amino Acids;analog;Anatomy;Animals;Antibiotics;Aspartic Acid;Bacillus Calmette-Guerin Therapy;BCG Live;BCG Vaccine;Behavior;Biodistribution;Biological Assay;Biological Markers;Bladder;Bladder Neoplasm;Bypass;cancer cell;Cancer Patient;cancer recurrence;cancer therapy;Catheterization;Catheters;Charge;Chemicals;chemotherapy;clinical translation;combinatorial;Combined Modality Therapy;comparative;cost;Data;Deposition;design;Diagnosis;digital;Disease;Disease Management;Doxorubicin;Drug Carriers;Drug Delivery Systems;Drug Kinetics;Excision;Excretory function;flexibility;functional group;Goals;high risk;Hospital Costs;Human;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunocompetent;Immunotherapy;Implant;improved;improved outcome;in vivo;Infection;Infective cystitis;Infusion procedures;inhibitor;interest;Intravenous;intravesical;Kidney;Length;Liver;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Microtubules;minimally invasive;Mitomycins;Morbidity - disease rate;mortality;Mus;muscle invasive bladder cancer;non-muscle invasive bladder cancer;novel;novel strategies;Operative Surgical Procedures;Optics;Organ;Outcome;Output;Pain;Patient Compliance;Patients;pembrolizumab;peptide analog;Peptides;Pharmaceutical Preparations;Pharmacotherapy;precision drugs;preclinical study;preservation;Procedures;Property;protein aminoacid sequence;Quality of life;Radical Cystectomy;Recurrence;Recurrent disease;Renal clearance function;Residual Cancers;Reticuloendothelial System;Serine;Spleen;standard care;Surface;survival outcome;Survival Rate;Symptoms;System;Techniques;Therapeutic Studies;Time;Toxic effect;Transitional Cell Carcinoma;translational study;treatment duration;Treatment Efficacy;Treatment outcome;treatment response;Treatment-related toxicity;tumor;tumor microenvironment;United States Food and Drug Administration;uptake;urinary;Urinary system;Urinary tract;Urine;Urothelium;X-Ray Computed Tomography

PROJECT_TITLE: An urinary drug disposing approach for treatment of bladder Cancer

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRITIVE Infertility affects 1 in 10 couples. The work proposed in this grant investigates a novel preimplantation gene, Bmal1, and its role in the proper development of healthy oocytes and progression of the maternal to zygotic transition. This work addresses one of the stated goals from the NICHD’s strategic plan, identify factors related to infertility.

PI_NAMEs: CASSIN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Address;Affect;Animals;Area;ARNTL gene;Bioinformatics;blastocyst;Cells;circadian;circadian biology;circadian regulation;Couples;Crying;Cytoplasm;Data;Defect;Deposition;Development;DNA Sequence Alteration;Early Gene Transcriptions;Embryo;embryo culture;Embryology;Embryonic Development;epitranscriptomics;Exhibits;experimental study;Failure;Feedback;Female;Fertilization;Fetal Development;field study;Foundations;Future;gene network;Genes;Genetic Transcription;Genome;Goals;Grant;Human;Hypothalamic structure;idiopathic infertility;Immunofluorescence Immunologic;Implant;In Situ Hybridization;Infertility;insight;Investigation;knock-down;Knock-out;Live Birth;live cell imaging;Maternal Messenger RNA;Mentors;Messenger RNA;Methods;Modeling;molecular clock;Monitor;Morphology;Movement;mRNA Transcript Degradation;multiple omics;Mus;National Institute of Child Health and Human Development;novel;offspring;oocyte quality;Oocytes;Oogenesis;Ovary;Phase;Phenotype;Pre-implantation Embryo Development;Pregnancy;preimplantation;programs;Proteins;Regulation;Regulatory Pathway;Reporter;Research;ribosome profiling;RNA;RNA immunoprecipitation sequencing;RNA-Binding Proteins;Role;single-cell RNA sequencing;skills;Strategic Planning;System;Techniques;Testing;Time;Training;transcriptome;Translating;Translational Regulation;Translations;Venus;Wild Type Mouse;Work;Writing

PROJECT_TITLE: EXAMINING THE ROLE OF BMAL1,  A NOVEL MATERNAL FACTOR IN PREIMPLANTATION DEVELOPMENT

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Triple-negative breast cancer (TNBC) has the worst outcome among breast cancer types, and is common among women of African ancestry. Known differences exist between the genetic and epigenetic drivers of TNBC between tumors of different genetic ancestries, including some that affect therapy choice. We propose a pilot study of largely unstudied genetic regions in tumors from a diverse population to increase the patient population eligible for targeted therapy in TNBC.

PI_NAMEs: ELLISEN, LEIF W;RHEINBAY, ESTHER  (contact)

PROGRAM_OFFICER_NAME: WALLACE, TIFFANY A

PROJECT_TERMS: activating transcription factor;Address;Affect;African ancestry;African Women;Asian;Automobile Driving;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Markers;Blood;Boston;brca gene;BRCA1 gene;Breast Cancer Model;Breast Cancer Patient;cancer genome;cancer type;candidate identification;Cell Line;Cells;Cellular Stress;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;cohort;Collaborations;Data;Data Set;Dependence;Detection;DNA;DNA Methylation;DNA Repair;DNA Sequence;driver mutation;Dropout;drug sensitivity;Eligibility Determination;Enhancers;Ensure;Epigenetic Process;epigenetic silencing;epigenomics;ERBB2 gene;Estrogen Antagonists;Estrogen Receptors;Evaluation;Event;exome;exome sequencing;Family;Frequencies;Future;Gene Expression;Genes;Genetic;Genome;Genomics;Germ Lines;Germ-Line Mutation;Hand;homologous recombination;homologous recombination deficiency;Hospitals;in silico;In Vitro;inhibitor therapy;innovation;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;Mediating;Medical center;Methylation;Mexican;Modeling;Molecular;multidisciplinary;Mutation;New England;novel;Nucleic Acid Regulatory Sequences;Oncogenes;Outcome;patient population;Patients;Phenotype;Pilot Projects;Poly(ADP-ribose) Polymerase Inhibitor;Population Heterogeneity;Predisposition;promoter;Promoter Regions;Proteins;Publishing;RAD51C gene;recruit;Recurrence;Research;Resistance;Risk;safety net;Sampling;Somatic Mutation;Specimen;targeted treatment;Technology;Testing;The Cancer Genome Atlas;Therapeutic;therapy outcome;Tissues;TP53 gene;transcription factor;transcriptomics;Translating;treatment response;triple-negative invasive breast carcinoma;tumor;tumor progression;Tumor Suppressor Proteins;Untranslated RNA;Validation;Variant;White Women;whole genome

PROJECT_TITLE: Landscape and characterization of promoter mutations driving triple-negative breast cancer

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pain Research;Patient Safety;Physical Rehabilitation;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_CITY: SAN DIEGO

ORG_DEPT: NUTRITION

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Project Narrative Spine pain is among the most common and disabling health conditions for both non-Hispanic whites (NHWs) and racial/ethnic minorities. Although Hispanics often report more severe pain than NHWs, they are less likely to consult a healthcare professional for pain management and health care providers are less likely to assess and treat pain in Hispanic patients. Consistent with the U.S. Department of Health and Human Services National Pain Strategy, this proposal aims to mitigate ethnic disparities in access to and engagement in non- pharmacological treatment options for pain by addressing barriers at multiple levels of influence along the care continuum in a Federally Qualified Health Center serving diverse, low-income communities.

PI_NAMEs: GOMBATTO, SARA P;MONROE, KATRINA S. (contact)

PROGRAM_OFFICER_NAME: PATEL, ANURADHA DIPAK

PROJECT_TERMS: access disparities;Address;Adherence;Affect;Award;Behavioral;Caring;Clinic;Clinical;clinical infrastructure;Clinical Practice Guideline;Clinical Trials;Cognitive;Communities;Consult;Consultations;Continuity of Patient Care;cost;Development;Disabling condition;disparity reduction;Effectiveness;effectiveness evaluation;efficacy testing;Electronic Health Record;environmental stressor;ethnic disparity;ethnic minority;evidence base;Evidence based intervention;Evidence based program;Exercise Therapy;Exposure to;Family health status;feasibility testing;Federally Qualified Health Center;Focus Groups;Goals;Guidelines;Health;Health Disparities Research;Health Personnel;Health Professional;Healthcare;Healthcare Systems;Hispanic;hispanic community;Hispanic Populations;Improve Access;improved;Individual;Inequity;Information Technology;Institution;Intervention;Latino Population;Linguistics;Low Back Pain;Low income;Managed Care;Manuals;Medical Care Costs;medical specialties;Methods;Mexico;minority health;minority health disparity;Modeling;musculoskeletal injury;Musculoskeletal Pain;National Institute on Minority Health and Health Disparities;Navigation System;Neck;Nonpharmacologic Therapy;Not Hispanic or Latino;Pain;Pain management;pain reduction;pain rehabilitation;Participant;Patient Compliance;patient engagement;Patients;Physical Rehabilitation;Physical therapy;Physicians;poor health outcome;preference;Primary Care;primary care provider;primary outcome;Productivity;programs;Provider;psychological stressor;Quality of life;racial minority;Randomized;Recommendation;recruit;Recurrence;Reporting;Research Design;Research Project Grants;Risk;Self Efficacy;Services;Severities;social stressor;Spine pain;standard care;Surveys;System;Testing;Therapeutic Intervention;United States;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities

PROJECT_TITLE: Salud de tu Espalda Primary Care to Physical Therapy (STEPPT): Mitigating ethnic disparities in access and engagement in spine pain rehabilitation

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Headaches;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pain Research;Patient Safety;Primary Health Care

PHR: Project narrative The proposed research is relevant to public health because it improves the quality of care and patient outcomes during care transitions. The new and improved health information technology solutions proposed in this project can facilitate an integrated multi-disciplinary approach to improving care transitions by defragmenting information, improving communication, and assuring the care team has access to reliable and complete health information that may be located in other care settings or disparate systems. The proposed research is also relevant to the part of the NLM’s strategic plan that focuses on enabling interoperability of clinical systems and meaningful use of electronic health records, and effective translation of new knowledge into practice.

PI_NAMEs: PENG, YIFAN  (contact);ROUSSEAU, JUSTIN FREDERICK

PROGRAM_OFFICER_NAME: REDDY, GOUTHAM

PROJECT_TERMS: Affect;Age;Algorithms;Articulation;Artificial Intelligence;Automated Abstracting;burnout;care coordination;care outcomes;Caring;Clinical;Clinical Medicine;Code;cognitive load;cohort;Collaborations;common symptom;Communication;Continuity of Patient Care;Data;data modeling;Data Science;Data Scientist;deep learning;Diagnosis;Diagnostic;Diagnostic Errors;Disabling;Disparate;electronic health data;electronic health information;Electronic Health Record;electronic structure;Electronics;empowerment;Ensure;evidence base;evidence based guidelines;experience;Generations;Guidelines;Headache;Headache Disorders;Health;health information technology;Healthcare Systems;heterogenous data;Human;improved;Informatics;innovation;Institution;interdisciplinary approach;interoperability;Judgment;Knowledge;Link;Manuals;Measures;Methods;Modeling;multimodality;Natural Language Processing;Neurologist;novel;Outpatients;Patient Care;Patient-Focused Outcomes;Patients;Performance;Persons;Physicians;Population;prevent;Primary Care;primary care provider;Process;prototype;Provider;Public Health;Quality of Care;Race;Research;Site;Socioeconomic Status;Specialist;Strategic Planning;success;Symptoms;syntax;System;Techniques;Technology;Testing;Text;Time;Training;Translations;Triage;United States;United States National Library of Medicine;user centered design;Visit;Writing

PROJECT_TITLE: Closing the loop with an automatic referral population and summarization system

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Health Services;Palliative Care

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Project Narrative The proposed research study explores patient and caregiver dyadic factors that can influence the quality of end of life (EOL) care for patients with advanced cancer and their informal caregivers. This is a very unique study because it is looking at how close (or far apart) patients and their informal caregivers are in their assessments of the severity of patient symptoms, their understanding of the patient’s EOL values, and their understanding of the patient’s EOL preferences for treatment. The study is highly relevant as it will provide information that has not been obtained before that can help guide methods of providing information and support at EOL for patients with advanced cancer and their informal caregivers.

PI_NAMEs: DOUGLAS, SARA L. (contact)

PROGRAM_OFFICER_NAME: FERRER, REBECCA

PROJECT_TERMS: Advance Care Planning;Advanced Malignant Neoplasm;aggressive therapy;Caregivers;Caring;Categories;Cessation of life;Collaborations;Communication;Consensus;contextual factors;Correlation Studies;Development;Diagnosis;Distant Metastasis;Emergency department visit;end of life;end of life care;end-of-life decision making;Ensure;Exclusion;experience;Family;Fostering;Goals;Grief reaction;Health;health care service;Health Personnel;Healthcare;Hospice Care;hospice utilization;Hospitalization;improved;Individual;informal caregiver;insight;Intervention;Investigation;Knowledge;Length of Stay;loved ones;Malignant Neoplasms;Mediating;member;Methods;Modeling;Outcome;Palliative Care;Patient Care;Patient Preferences;Patients;Play;preference;Process;provider factors;Proxy;Quality of Care;Quality of life;Research;research study;Resources;Risk;Role;satisfaction;Science;Severities;social;Symptoms;Theoretical model;theories;Time;Value of Life

PROJECT_TITLE: Improving Understanding of Quality End of Life Care Using a Dyadic Approach

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Neurosciences;Orphan Drug;Physical Rehabilitation;Rare Diseases;Rehabilitation;Stroke

ORG_CITY: ORLANDO

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on developing an alternative method to optimize treatment response and provide more economical and accessible practice opportunities for persons with post-stroke apraxia of speech. The results of the proposed study will help establish new methods for clinical care and shift the way speech therapy is offered to people with apraxia of speech and other neurogenic communication disorders. Thus, the proposed research addresses NIDCD’s Priority Areas: (Area 3) to improve treatment of disorders of human communication and (Area 4) to improve outcomes for human communication.

PI_NAMEs: BISLICK (WILSON), LAUREN  (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: acceptability and feasibility;Address;adherence rate;Affect;Aftercare;Apraxia;Area;Articulation;Behavior Therapy;Behavioral;Brain;Brain region;Caring;Clinic;Clinical;clinical care;Clinical Trials;Communication;comparative efficacy;Computers;cost;cost effective;Data;Disease;Dose;Economically Deprived Population;efficacy evaluation;Evaluation;evidence base;Evidence based treatment;Experimental Designs;Foundations;Goals;Home;Human;Imagery;improved;improved outcome;innovation;Intervention;Interview;Kinesthesis;Laboratories;Language;laptop;learning engagement;Measures;meetings;Methods;Mind;Motor;motor learning;multilevel analysis;National Institute on Deafness and Other Communication Disorders;neural network;Neurogenic Communication Disorders;novel;Outcome;Participant;Pathologist;Patients;payment;Persons;Phase;Physical Rehabilitation;Population;post stroke;Production;programs;Protocols documentation;Public Health;Publishing;recruit;Regimen;Rehabilitation therapy;Research;response;satisfaction;Services;sound;Speech;speech accuracy;Speech Intelligibility;Speech Therapy;Stimulus;Stroke;stroke survivor;Structure;support network;Surveys;System;Time;tool;Training;treatment effect;Treatment Efficacy;treatment optimization;Treatment outcome;treatment response;Variant;Work

PROJECT_TITLE: Motor Imagery for Treatment Enhancement and Efficacy (MI-TEE) in Persons with Apraxia of Speech

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: EAST LANSING

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE The spread of tuberculosis is a global health crisis leading to over one million deaths annually. The global burden of tuberculosis is a threat to the health of all Americans, and directly relevant to the mission of the National Institute of Allergy and Infectious Diseases, given the easy transmission of the disease through the air and the emergence of drug resistant strains that are difficult to treat. Infections with non-tuberculous mycobacterial infections are also a serious problem in the United States, particularly in individuals with underlying conditions such as Cystic Fibrosis or chronic obstructive pulmonary disease.

PI_NAMEs: ABRAMOVITCH, ROBERT B (contact);ELLSWORTH, EDMUND L

PROGRAM_OFFICER_NAME: BOYCE, JIM P

PROJECT_TERMS: Acute;Air;American;analog;Antibiotics;bactericide;Biological Availability;Biology;Cells;Cessation of life;Chemicals;Chronic Obstructive Pulmonary Disease;Cluster Analysis;Collection;Cord Factors;Cystic Fibrosis;cytotoxicity;Data;design;Development;Disease;disease transmission;Dose;drug development;Drug Kinetics;Drug resistance;Drug resistant Mycobacteria Tuberculosis;efficacy study;Ethambutol;Evolution;Exhibits;experimental study;fitness;Frequencies;Genus Mycobacterium;global health;Goals;Growth;Health;high throughput screening;In Vitro;in vivo;Individual;Infection;inhibitor;innovation;interest;isoniazid;knock-down;Libraries;Macrophage;Membrane Proteins;Microsomes;Mission;Modeling;mouse model;Mus;mutant;mycobacterial;Mycobacterium abscessus;Mycobacterium smegmatis;Mycobacterium tuberculosis;mycolate;National Institute of Allergy and Infectious Disease;non-tuberculosis mycobacteria;non-tuberculous mycobacterial infection;novel;Oral;Pharmaceutical Preparations;Phenotype;Pyrazinamide;rational design;Resistance;resistance frequency;resistance mechanism;resistance mutation;Resistance profile;resistant strain;response;Rifampin;scaffold;Series;Solubility;standard of care;Structure;Structure-Activity Relationship;therapeutic target;tool;Trehalose;Tuberculosis;tuberculosis drugs;United States

PROJECT_TITLE: Chemical biology studies of MmpL3 inhibition and resistance in mycobacteria

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Dysfunction in how the brain uses feedback to guide future decisions is a primary mechanism for many public health problems (e.g., addiction). This research program will provide new insights into how neural circuits give rise to decision-making and how environmental contexts (e.g., dynamic continuous and discrete actions) regulate brain network configurations to produce behavioral flexibility, providing key insights into the neural systems that give rise to addictive behaviors and other public health problems.

PI_NAMEs: RUBIN, JONATHAN E.;VERSTYNEN, TIMOTHY D (contact)

PROGRAM_OFFICER_NAME: MOLLICK, JESSICA ANN

PROJECT_TERMS: addiction;Addictive Behavior;analytical method;arm;Behavior;Behavioral;Brain;Cells;cognitive process;Computer Models;Coupled;Data;Decision Making;Development;Diffusion;dimension reduction;Dimensions;Electrophysiology (science);Encapsulated;Entropy;Environment;Environmental Risk Factor;experimental study;Feedback;flexibility;Functional disorder;Future;Ganglia;generative models;in silico;in vivo;Individual;insight;Investigation;Learning;Link;Maps;Measures;Mediating;Modeling;motor control;Mus;network models;neural;neural circuit;novel;Obesity;Opiate Addiction;optogenetics;Pathway interactions;Pattern;Policies;Population;Process;programs;Property;Public Health;Research;reward processing;Rewards;Rodent;Series;Side;Signal Transduction;spatiotemporal;Stream;Structure;System;Testing;Thalamic structure;theories;two-dimensional;Update;Work

PROJECT_TITLE: CRCNS: Decision dynamics in cortico-basal ganglia-thalamic networks

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-P(50)R]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Age-related deficits in auditory processing are associated with increased reliance on listening effort in comprehension of speech in complex acoustic backgrounds. This research will provide insights about the effects of age on relationships between different measures of effort, and between effortful listening and neural representations of speech. These findings will be an important first step towards characterizing the role of different cognitive processes within the language processing hierarchy and may inform development of novel diagnostic measures for speech perception deficits that are missed by traditional clinical tests.

PI_NAMEs: MESIK, JURAJ  (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TITLE: Physiological markers of listening effort and their dependence on age


ORG_CITY: Columbus

ORG_DEPT: CHEMISTRY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative  The following research proposal will develop broadly-applicable strategies for new synthetic-organic meth- odologies that are particularly suited for the preparation or late-stage modification of natural products and phar- maceuticals. These synthetic strategies all rely on electrical energy as a means to (i) promote challenging – but desirable – reactions, (ii) eliminate the need for expensive or hazardous reagents, and (iii) reduce the synthetic steps required to access the target molecules. As a result of streamlining synthesis, these findings will accelerate the identification of new therapeutics and allow their preparation on large scale with lower costs to the public.

PI_NAMEs: SEVOV, CHRISTO  (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TITLE: Late-stage C-H functionalization and C-C/N coupling enabled by new strategies for electrochemically-controlled radical formation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-P(55)R]


ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: PROJECT NARRATIVE A number of cytoplasmic proteins regulating fundamental biological processes including innate immunity and blood vessel formation are known to be secreted into the extracellular space through unconventional pathways. This proposal seeks to elucidate the molecular mechanisms that enable this unconventional protein secretion, with the potential to identify novel drug targets for the treatment of a number of human diseases.

PI_NAMEs: ABBINENI, PRABHODH SAI (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Adipocytes;angiogenesis;Autophagocytosis;Autophagosome;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biology;blood vessel development;Brefeldin A;Cell membrane;cell type;Cells;complement C2a;CRISPR screen;CRISPR/Cas technology;cytokine;Cytolysis;Cytoplasm;Cytoplasmic Protein;Data;Destinations;Disease;drug development;Endoplasmic Reticulum;Endosomes;experimental study;Extracellular Space;fatty acid-binding proteins;Fluorescence Microscopy;Foundations;functional genomics;Genes;genome-wide;Goals;Golgi Apparatus;Growth Factor;hepatoma cell;human disease;Inflammation Mediators;Inflammatory Response;interest;Interleukin-1 beta;Kidney;Lipids;Mass Spectrum Analysis;Membrane;Mentors;Methodology;Methods;Molecular;Molecular Genetics;monocyte;Natural Immunity;Neurons;new therapeutic target;novel;Organelles;Pathogenicity;Pathway interactions;Peptide Signal Sequences;pharmacologic;Phosphatidylinositols;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;PIK3CG gene;Play;Process;programs;Protein Biosynthesis;Protein Secretion;protein transport;Proteins;Proteomics;Regulation;Research;Research Personnel;Resistance;response;Role;Route;Secretory Vesicles;stressor;System;targeted treatment;Testing;tool;Training;Work

PROJECT_TITLE: Examining Molecular Regulation of Unconventional Cytoplasmic Protein Secretion

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Contraception/Reproduction;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative Maternal health disparities, uterine dysfunction and childbirth-related morbidity are associated with maternal aging; however, individual morbidity linked to aging is better predicted by epigenetic age, a measure of biological age. My research will leverage a robust biomarker of aging, Epigenetic Clock, to understand how a woman’s epigenetic age relates to both uterine function/dysfunction during birth and her self-reported burden of psychosocial and socioeconomic stress during pregnancy. This work will shed critical light on the complex integrated relationship between social and physical environmental exposures and biological changes that underpin maternal health disparities.

PI_NAMEs: ERICKSON, ELISE N (contact)

PROGRAM_OFFICER_NAME: TYUS, NADRA

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;adverse outcome;Age;age acceleration;age group;age related;Age Years;Aging;aging biomarker;American;Binding;biobank;Biological;biological age;Biological Aging;Biological Markers;Biological Specimen Banks;Birth;Blood;Blood specimen;career development;Cesarean section;chemical group;Childbirth;Chronology;Clinical Data;Complex;Data;data repository;Data Set;DNA;DNA Methylation;Economics;Elderly;Enrollment;Environment;Environmental Exposure;Epigenetic age;epigenetic aging;epigenetic clock;epigenetic marker;Epigenetic Process;experience;fetal;Fetal Tissues;Functional disorder;Gene Expression;genome wide association study;genome-wide;genomic data;Gestational Age;Goals;Health;Health Disparities Research;health disparity;high risk;High Risk Woman;Impairment;improved;in utero;indexing;Individual;Induced Labor;Infant;innovation;Knowledge;life span;Link;Maternal Health;maternal morbidity;Maternal Mortality;maternal outcome;Measures;Mediator;Messenger RNA;Methods;methylation pattern;Modeling;Modification;Morbidity - disease rate;mortality;Mothers;mRNA Expression;Myometrial;myometrium;National Institute of Child Health and Human Development;Newborn Infant;novel marker;Older Population;older women;Outcome;Patient Self-Report;Perinatal Care;perinatal morbidity;Personal Satisfaction;Persons;Phenotype;Postpartum Hemorrhage;predictive marker;Pregnancy;Pregnancy Outcome;Prolonged labor;Proteins;Psychometrics;psychosocial;Psychosocial Stress;repository;Research;Research Methodology;Role;Sampling;sex;Site;social;social adversity;Social Environment;social stress;socioeconomics;Source;Stress;stressor;Testing;Ticks;Tissues;tool;Training;Umbilical Cord Blood;United States;uterine contractility;Uterus;Woman;Work;young woman

PROJECT_TITLE: The Clock is Ticking: Epigenetic Age Acceleration as a Biomarker of Uterine Function in Pregnancy

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(78)]


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Acidic environment is crucial for the function of many intracellular organelles, and is also one of the pathological hallmarks of various diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation. This proposed research program will focus on a new family of acid receptor: how its activity is regulated and what role it plays in physiology and disease.

PI_NAMEs: QIU, ZHAOZHU  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Acidosis;Acids;Animals;Anions;Area;Biology;Calcium Channel;Cell Death Induction;cell injury;Cell Volumes;Cells;Cerebral Ischemia;Chloride Channels;Chlorides;Cryoelectron Microscopy;Cystic Fibrosis;Disease;Drug Targeting;Electrophysiology (science);Environment;Epilepsy;Family;Fluids and Secretions;Functional disorder;functional genomics;Funding;Genetic Diseases;Goals;imaging genetics;In Vitro;in vivo;Infection;Inflammation;interdisciplinary approach;Ion Channel;Ions;Ischemic Brain Injury;Knockout Mice;Malignant Neoplasms;Mediating;Membrane Proteins;Molecular;Molecular Conformation;mouse genetics;Mutagenesis;Myocardial Ischemia;Myotonia;novel;Organelles;patch clamp;Pathologic;Pathway interactions;Physiological;Physiology;Play;Potassium Channel;programs;Protons;receptor;Regulation;Research;RNA interference screen;Role;Sodium Channel;Stroke;structural biology;Swelling;Time

PROJECT_TITLE: Molecular Identity and Physiological Function of Novel Chloride Channels

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOZEMAN

ORG_NAME: HOPA MOUNTAIN

ORG_STATE: MT

PHR: NARRATIVE Hopa Mountain, working in partnership with MSU’s WWAMI Medical School, proposes to develop a Medical Mentorship program that will provide near peer mentors to Montana high school students interested in becoming physicians or other types of health care professionals. The primary goal of the Medical Mentorship program is to help students learn more about medical careers and how to apply to and graduate from institutions of higher learning with a health sciences or biomedical research degree. Medical Mentorship will connect high school students with undergraduate and medical school mentors, including first and second year WWAMI Medical School students, who can help students prepare for careers in medicine and learn how to succeed in college while working toward a STEM degree. Some of the most powerful tools-- mentoring, role modeling, and career exposure—have been shown to be effective in a variety of settings. Mentoring and support encourages engagement in science, math, and engineering careers. Given the vast distances between these high school students and those in a university setting, this near- peer mentoring program will take place primarily through peer-led group learning through collaborative learning technologies for students who are not co- located in a lab or work-based setting. . Hopa Mountain will develop innovative training and mentoring opportunities for low-income, first generation, and reservation-based Montana high school students to strengthen their STEM skills and prepare them for higher education and careers in health sciences. The overall project goal of Medical Mentorship is to support rural and tribal youth’s interest in and exposure to careers in the biomedical and health sciences while giving them the skills to play leadership roles in increasing healthy family practices in their homes and communities. Medical Mentorship will have meaningful impacts annually through three strategies: (1) Year-round mentoring and college preparation programs for 250 teens to explore health career options; (2) Medical Mentorship: Food as Health materials and programs for 2,000 children and families; and (3) Professional development for 200 educators, community members, and parents.

PI_NAMEs: SACHATELLO-SAWYER, BONNIE  (contact)

PROGRAM_OFFICER_NAME: MOTEN, CARMEN

PROJECT_TERMS: Biomedical Research;career;career preparation;Caregivers;Child;Collaborations;college;College Preparation;Communities;Development;Educational process of instructing;Educational workshop;Emotional;Engineering;Exposure to;Family;Family Practice;Food;food resource;Funding;Generations;Goals;Health;Health Professional;Health Resources;Health Sciences;high school;high school program;High School Student;higher education;Home;Hygiene;improved;innovation;Institution;interest;Leadership;Learning;Low income;Mathematics;Medical;medical schools;Medical Students;Medicine;member;Mentors;Mentorship;Montana;nutrition;Parents;Participant;Pathway interactions;peer;peer coaching;Physicians;Play;Preparation;programs;Recipe;reservation-based;Resources;Role;role model;Rural;Rural Community;Schools;Science;skills;social;Students;teacher;Technology;Teenagers;tool;Toothbrushing;Training;training opportunity;tribal community;Tribes;undergraduate student;underserved students;United States National Institutes of Health;Universities;Work;Youth

PROJECT_TITLE: Medical Mentorship: Building Pathways to Health Careers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-L (55)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease

PHR: Using a mouse model in which we can control the timing of mutant gene activation, we will determine the stage/s in which a known Parkinson disease (PD) mutation acts. Although clinical symptoms of PD arise later in life, we do not know whether the influence of known mutations are sustained throughout life, or at a discrete time interval. This question becomes critical in the search for more effective therapeutic strategies, the identification of the optimal window of therapeutic intervention, the discovery of mutations that contribute to PD, and the development of more accurate assays to measure their biological impact.

PI_NAMEs: KO, HANSEOK ;MCCALLION, ANDREW S (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, LUIS FLANAGAN

PROJECT_TERMS: Address;Adolescent;Adult;Affect;Age;Age Months;aging related disease;Agonist;alpha synuclein;analog;Animal Model;Anosmia;Behavioral;behavioral phenotyping;Biological;Biological Assay;causal variant;cell type;Clinical;Clinical Trials;Cognitive deficits;cohort;comparison control;Compensation;Constipation;Data;density;derepression;Development;Diagnosis;discrete time;Disease;disease model;Disease Progression;disease-causing mutation;dopaminergic neuron;Doxycycline;drug efficacy;Early Intervention;Embryo;Ensure;Excision;Experimental Designs;Fluorescent in Situ Hybridization;Gene Activation;glial activation;GLP-I receptor;Histologic;Homeobox;Human;Immune response;Immunohistochemistry;Impaired cognition;Internal Ribosome Entry Site;Intestines;Late-Onset Disorder;Levodopa;Life;Measures;Mediating;Mental Depression;Midbrain structure;Modeling;motility disorder;Motor;motor deficit;motor disorder;motor symptom;mouse model;Movement Disorders;Mus;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neurologic Effect;neuron loss;Onset of illness;Outcome Measure;Parkinson Disease;Pathogenesis;Pathologic;Pathology;Patients;Persons;Phenotype;Pituitary Gland;Population;Population Study;postnatal;Pregnancy;progressive neurodegeneration;Proteins;Repression;Research;screening;single molecule;Sleep disturbances;sporadic Parkinson's Disease;Substantia nigra structure;symptom management;Symptoms;synuclein;Testing;Tetracyclines;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;time interval;timeline;Trans-Activators;Transcript;Transgenes;Treatment Efficacy;Western Blotting;Work

PROJECT_TITLE: Determining the critical time window of action of Parkinson mutant alpha synuclein expression in mice

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Rare Diseases

ORG_DEPT: NEUROLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Therapeutic Targeting in EGFR-amplified Glioblastoma  Despite the established role of EGFR amplification as an oncogenic driver in glioblastoma (GBM) and continuous efforts to target EGFR for GBM treatments, our knowledge of the mechanisms involved in EGFR- driven GBM malignancy and clinical failures of EGFR-targeting therapies for treating GBM is incomplete. In this project, we propose to explore new therapeutic approaches for EGFR-amplified GBM by assessing the role of a largely uncharacterized gene that is co-amplified with EGFR in GBM biology and therapy response.

PI_NAMEs: CHENG, SHI-YUAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Adult;Affect;Antisense Oligonucleotides;Binding;Binding Proteins;Biological;Biological Markers;Biology;BMI1 gene;Brain;Cell Nucleus;Cell Physiology;Cells;Central Nervous System Neoplasms;Chemoresistance;Chromatin;Classification;Clinical;Data;Elements;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;Failure;Gene Amplification;Gene Expression;Genes;Genetic Transcription;Glioblastoma;Glioma;Goals;Heterogeneity;In Vitro;Individual;innovation;interest;Knowledge;Malignant - descriptor;Malignant Neoplasms;Mediating;Membrane;Mutation;neoplastic cell;Normal Cell;novel therapeutic intervention;Nuclear;Nuclear Protein;Nuclear Proteins;Nuclear RNA;Oncogenic;Pathway interactions;Physical condensation;PRC1 Protein;prevent;Prognosis;Property;Proteins;Proto-Oncogenes;Purines;radiation response;Resistance;response;RNA;RNA Binding;RNA Processing;Role;Signal Transduction;stem cells;Subcellular structure;targeted treatment;temozolomide;Therapeutic;therapeutic target;transcriptome;treatment response;tumor;tumor heterogeneity;tumor progression;Tumor Subtype;Tumor Suppressor Proteins;tumor-immune system interactions;Tumorigenicity;Untranslated RNA

STUDY_SECTION: MCTC

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics C Study Section [MCTC]


PHR: Project Narrative The importance of germline predisposition to myeloid malignancies is now well-established in hematology, and the Myeloid Malignancy Variant Curation Expert Panel (MM-VCEP), co-chaired by Drs. Lucy A. Godley and David Wu, has developed, implemented, and revised RUNX1 curation rules, with similar rules to be completed for DDX41/GATA2 by Jan 2024, and ANKRD26/ETV6 by Mar 2024. In this renewal application, the MM-VCEP seeks to expand its gene portfolio to include CEBPA as well as SAMD9/SAMD9L, major drivers of pediatric MMs, and TERT/TERC, causes of telomere biology disorders and adult-onset MMs. The MM-VCEP seeks to classify variants whenever possible in the pathogenic/likely pathogenic range and will use innovative approaches to applying segregation codes at their strongest levels by incorporating: (i) three patient/family-focused organizations [ConnectMyVariant, the RUNX1 Research Program, and Team Telomere, Inc.]; and (ii) additional variant databases that complement the resources available in ClinVar [the St. Jude Children’s Research Hospital SAMD9/SAMD9L variant database and the Clinical Care Consortium for Telomere-Associated Ailment international registry].

PI_NAMEs: GODLEY, LUCY ANN (contact);WU, DAVID

PROGRAM_OFFICER_NAME: ROTUNNO, MELISSA

PROJECT_TERMS: Adult;Allogenic;American Society of Hematology;Anemia;Aplastic Anemia;Area;Awareness;Biology;Blood Platelets;Bone marrow failure;Calendar;Cancer Detection;Caring;CEBPA gene;Child;Childbirth;Childhood;Classification;Clinical;clinical care;ClinVar;Code;Collaborations;Collection;complement resource;Consensus;Country;curative treatments;Data;Databases;Defect;Deposition;Detection;Development;Diagnosis;diagnostic criteria;Disease;Dysmyelopoietic Syndromes;ETV6 gene;European;Family;Functional disorder;Funding;Genes;genome resource;Germ Lines;Germ-Line Mutation;Goals;Hematology;Hematopoietic Neoplasms;Hematopoietic Stem Cell Transplantation;Infrastructure;innovation;Institution;interest;International;Interstitial Lung Diseases;Investments;Laboratories;Lead;Malignant Neoplasms;Medical Societies;Medicine;member;Mission;Myeloproliferative disease;National Comprehensive Cancer Network;novel;Online Systems;Operative Surgical Procedures;Organ;paralogous gene;Pathogenicity;Patients;Phenotype;phenotypic data;Physicians;Predisposition;Productivity;programs;Provider;Pulmonary Fibrosis;Regimen;Registries;Research;Research Personnel;Resources;Risk;RUNX1 gene;Saint Jude Children's Research Hospital;Scientific Societies;segregation;Subgroup;surveillance strategy;Surveys;Susceptibility Gene;Syndrome;telomere;Testing;Time;United States National Institutes of Health;Update;Variant;Work;World Health Organization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MGG-V (50)]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Brain Disorders;Cerebral Palsy;Cerebrovascular;Childhood Injury;Disability Research;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Stroke;Unintentional Childhood Injury

ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

PHR: Neonatal hypoxic-ischemic (HI) brain injury resulting in intellectual impairment and cerebral palsy (CP) affects more than 10,000 infants each year in the United States. There is no therapy other than supportive care to ‘treat’ brain damage in premature infants. These preclinical studies will increase our understanding of mechanisms of a new therapy that could attenuate/prevent brain injury in infants.

PI_NAMEs: CHEN, XIAODI FELIX;MARSHALL, JOHN  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: Affect;Affinity;Anti-Inflammatory Agents;ANXA5 gene;Apoptosis;astrogliosis;Attenuated;behavior test;Behavioral;behavioral outcome;Binding;Biological Assay;Birth;Body Weight;Brain;Brain Hypoxia-Ischemia;Brain Injuries;brain tissue;brain volume;Brain-Derived Neurotrophic Factor;Cell Death;Cells;Cerebral Palsy;Clinical;Clinical Research;Complement;Complex;Cyclization;cytokine;cytotoxic;Data;Development;Developmental Disabilities;Dose;Drug Kinetics;Electrophysiology (science);Event;excitotoxicity;Exhibits;Exposure to;field study;fluoro jade;Free Radicals;Generations;glial activation;Goals;Half-Life;Hippocampus;Histologic;Hour;hypoxic ischemic injury;immunoregulation;improved;Infant;infant brain injury;Inflammatory;Injury;Intellectual functioning disability;Intellectual impairment;Intervention;intraperitoneal;Intraperitoneal Injections;Investigation;Learning;Ligation;Long term disability;Long-Term Potentiation;Macrocyclic Compounds;Mediating;Medical;Memory;Microglia;mitochondrial dysfunction;mitochondrial membrane;Molecular;morris water maze;Motor;Multiprotein Complexes;N-Methyl-D-Aspartate Receptors;natural hypothermia;Nature;Neonatal Brain Injury;neonatal hypoxic-ischemic brain injury;neonate;Nerve Degeneration;Neuroglia;neuroinflammation;neuron apoptosis;neuron loss;Neurons;neuroprotection;novel;novel therapeutics;Oligodendroglia;Outcome;Oxidative Stress;Oxygen;Pathway interactions;Penetration;Peptides;peptidomimetics;Perinatal Brain Injury;Pharmaceutical Preparations;Plasma;preclinical study;Premature Infant;presynaptic density protein 95;prevent;Prevention;Property;protective effect;Rattus;Reactive Oxygen Species;receptor;receptor function;recruit;Reflex action;Research;response;Rodent Model;Scaffolding Protein;Series;Serum;Signal Induction;Signal Transduction;skills;Slice;Societies;Stains;standard of care;Supportive care;Synapses;synthetic polymer Bioplex;Testing;Therapeutic;Time;treatment strategy;United States;way finding;Work

PROJECT_TITLE: A novel BDNF potentiator for the treatment of neonatal brain injury

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: MISSOULA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MONTANA

PHR: Project Narrative In the western US, climate change is leading to more frequent wildfires that produce smoke that adversely impacts millions of people each year. By educating middle school and high school students about climate change, wildfires, and public health through research, we hope to raise awareness about these emerging crises within rural communities, as well as increase students’ interest in STEM careers and research.

PI_NAMEs: WARD, TONY JOHN (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Acceleration;Address;Air;Alaska;Alaska Native;American Indians;Area;Awareness;Burn injury;burnout;cardiovascular health;career;Career Choice;career preparation;Child;Climate;climate change;climate-related health;Communication;Communication Tools;Communities;community setting;COVID-19;Credentialing;data visualization;design;Development;Distance Learning;diversity and inclusion;Droughts;Education;education research;Educational Curriculum;Educational process of instructing;Educational workshop;Employee;Employee Health;empowerment;Evaluation;Event;experience;Face;falls;Fire - disasters;Frequencies;Funding;Future;Geographic Locations;Growth;Health;Health Personnel;Healthcare;high school;High School Student;Humanities;Hybrids;Idaho;improved;Indigenous;indigenous community;Indoor Air Pollution;Infrastructure;interest;junior high school;Knowledge;Learning;medically underserved;Methods;Middle School Student;Montana;National Oceanic and Atmospheric Administration;Persons;Predisposition;programs;Provider;Public Health;Research;Research Personnel;Research Project Grants;Rural;rural area;Rural Community;rural underserved;Science;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Self Efficacy;Smoke;STEM career;STEM field;STEM research;student participation;Students;symposium;teacher;Teacher Professional Development;Testing;tribal community;underserved area;underserved community;underserved students;Universities;Wildfire;World Health Organization;Writing

PROJECT_TITLE: Empowering Rural Students to Address Public and Climate Health Through Research


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Neurosciences

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE Dysfunctions of sensorimotor behaviors are among the most common and devastating aspects of neurological disorders. Converging evidence from humans and animal models indicate that the cerebello-thalamocortical and basal ganglia-thalamocortico pathways play critical and complementary roles in sensorimotor behaviors. However, we do not have a coherent understanding of how these pathways support the basic building blocks of sensorimotor behavior including coordination, integration, and learning. In this proposal, we will combine large-scale multi-region electrophysiology and multi-region neural network modeling to tease apart the complementary roles of these pathways in sensorimotor behavior. This work will elucidate the computational principles, anatomical substrates, and physiological mechanisms of sensorimotor function, and promises to facilitate the development of diagnostics and treatments for victims of neurological disorders.

PI_NAMEs: JAZAYERI, MEHRDAD  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Anatomy;Animal Model;Area;Basal Ganglia;Behavior;Brain;Cells;computer framework;diagnostic development;Discipline;Electrophysiology (science);Functional disorder;Goals;human model;knowledge integration;Learning;Link;Mathematics;Measurable;Modeling;multidisciplinary;Nervous System Disorder;neural;Neural Network Simulation;Neurobiology;neuromechanism;neurotransmission;nonhuman primate;Pathway interactions;Physiological;Play;Research;Resolution;Role;Sensorimotor functions;spatiotemporal;System;Techniques;Update;Variant;Work

PROJECT_TITLE: Subcortico-Cortical Mechanisms of Sensorimotor Coordination, Integration, and Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (35)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Our work will focus on novel regulatory mechanisms of regulation of mitochondrial function by O- GlcNAcylation in a neuroinflammation mouse model. Successful completion of the proposed studies will inform development and optimize effective therapeutics for the treatment of AD.

PI_NAMEs: QIN, HONGWEI ;ZHANG, JIANHUA  (contact)

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: 3xTg-AD mouse;Address;Adopted;Affect;Age Months;age related neurodegeneration;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease therapeutic;Amyloid beta-Protein;Astrocytes;Autopsy;beta amyloid pathology;Bioenergetics;Biology;Brain;Cells;Clinical Trials;Data;Defect;Dementia;deprivation;Development;efficacy testing;Electron Transport;Exhibits;Family;Foundations;gain of function;Gene Expression;genetic approach;Gliosis;Glucose;glucose metabolism;Glycolysis;Human;Impaired cognition;Impairment;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injections;insight;Knock-in Mouse;Link;lipid metabolism;Measurement;Measures;Metabolic;Metabolic Control;Metabolism;metabolomics;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;mitochondrial metabolism;Molecular Profiling;mouse model;Mus;mutant;Mutation;Nerve Degeneration;neurodegenerative phenotype;neuroinflammation;Neurons;Nitric Oxide;novel;overexpression;Oxidation-Reduction;Oxidative Stress;Pathogenesis;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;peptide O-linked N-acetylglucosamine-beta-N-acetylglucosaminidase;pharmacologic;Play;Post-Translational Protein Processing;protein aggregation;Proteins;Proteomics;Regulation;Reporting;Role;Signal Transduction;single-cell RNA sequencing;Societies;Synapses;targeted treatment;tau Proteins;tau-1;Tauopathies;Testing;Therapeutic;therapeutic development;therapeutically effective;transcriptomics;Transgenic Model;Wild Type Mouse;Work

PROJECT_TITLE: O-GIcNAc regulation of mitochondrial function in astrocytes inneuroinflammatory Alzheimer's disease mouse model

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Contraception/Reproduction;Drug Abuse (NIDA only);Genetics;Neurosciences;Opioid Misuse and Addiction;Opioids;Pediatric;Substance Misuse

ORG_CITY: BOSTON

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative Opioid use disorder runs in families, and growing evidence indicates that exposure to opioids increases the likelihood that the disorder will perpetuate in the following generations. These studies will utilize a rat model to determine potential mechanisms by which exposure to opioids in males can be transmitted to future progeny.

PI_NAMEs: VASSOLER, FAIR M (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: addiction;Adolescence;Adolescent;Adult;Affect;Animals;Artificial Insemination;Behavior;behavioral phenotyping;Brain;cell type;Clinical Data;Data;design;Deterioration;Development;Disease;DNA Methylation;Down-Regulation;drug of abuse;Economic Burden;endogenous opioids;Environment;environmental change;Environmental Exposure;Epigenetic Process;experience;experimental study;Exposure to;Family;Female;Fetal Development;Future;Gastrointestinal Motility;Generations;Genome;Goals;Grant;Heritability;Histone Acetylation;Immune response;inhibitor;insight;intergenerational;male;Male Adolescents;Measures;Mediating;Messenger RNA;MicroRNAs;Midbrain structure;Modeling;Modification;molecular phenotype;Morphine;morphine administration;mu opioid receptors;Mus;next generation;offspring;Oocytes;Opiate Addiction;opiate tolerance;Opioid;opioid epidemic;opioid exposure;Opioid Receptor;opioid use disorder;Overdose;oxycodone self-administration;Pain;Phenotype;Play;Population;pre-clinical;Predisposition;Pregnancy;Prevention;Productivity;prolonged abstinence;Rattus;receptor;receptor expression;Regulation;response;Rewards;RNA;Rodent;Role;Running;Saline;Self Administration;Seminal fluid;social;socioeconomics;sperm cell;stem cells;Stimulus;Substance abuse problem;Substance Use Disorder;System;Testing;Testis;Time;transgenerational epigenetic inheritance;Translations;transmission process;United States;Up-Regulation;Variant

PROJECT_TITLE: Let-7 in Sperm Impacts Offspring Opioid System

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Neurosciences

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative Mobile element insertions, caused by retrotransposon insertion, are an understudied source of genetic variation that have been linked to numerous neurological disorders through their modulation of alternative splicing. This proposal seeks to use large genomic datasets to characterize the associations between mobile element insertions and neurological disease, with a heavy emphasis on SINE-VNTR-Alu (SVA) elements, a hominid- specific retrotransposon with unique patterns of variation. This work will leverage the utility of transcriptomic data and long-read whole genome sequencing data for establishing mobile element insertions as an important component of neurological disease genetics.

PI_NAMEs: YENKIN, ALEX LONDON (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Alternative Splicing;Alu Elements;analytical method;Biology;Bipolar Disorder;Blood;Brain;career;case control;Catalogs;causal variant;Characteristics;Code;cohort;Complex;Computational Biology;Data;data access;Data Aggregation;Data Set;Discipline;Disease;DNA Insertion Elements;Doctor of Philosophy;Dorsal;Elements;Fellowship;functional genomics;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Variation;Genome;genome sequencing;genomic data;genomic locus;Genomic Segment;genomic variation;Genomics;Genotype;Genotype-Tissue Expression Project;Goals;hands on research;Hominidae;Human;human data;human disease;Human Genetics;Human Genome;improved;Individual;insight;Institution;Introns;laboratory experience;large datasets;Lateral;Libraries;Link;Mentors;Mentorship;Mind;Minisatellite Repeats;Nervous System Disorder;Neurodegenerative Disorders;Neurologic;neuropsychiatric disorder;neuropsychiatry;new technology;novel;Pattern;Population;Positioning Attribute;Prefrontal Cortex;Quantitative Trait Loci;Research;Research Support;Resources;Retrotransposon;RNA Splicing;Role;Sampling;Schizophrenia;Severities;skill acquisition;Source;Spliced Genes;symposium;TAF1 gene;Technology;technology development;Tissues;tool;Training;training opportunity;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Untranslated RNA;Variant;whole genome;Work;X-linked dystonia parkinsonism

PROJECT_TITLE: Uncovering the genomic and transcriptomic variation due to mobile elements in the population and in neurological disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Kidney Disease;Rare Diseases

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

PHR: NARRATIVE Clear cell renal cell carcinoma (ccRCC) is currently the 8th leading cause of cancer death in the United States and is unusual for its high frequency of epigenome regulator gene mutations, including a gene called SETD2 that when mutated, is associated with reduced survival and metastasis. SETD2 may regulate a novel mechanism that controls mRNA level and stability known as RNA methylation. This is exciting not only because it could represent a new way SETD2 loss drives cancer growth, but also because drugs are being developed to target RNA methylation that might be effective in treating SETD2 mutant renal cell cancer.

PI_NAMEs: ROBERTSON, KEITH D (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: Aberrant DNA Methylation;actionable mutation;Affect;AGFG1 gene;bevacizumab;Cancer Biology;Cancer cell line;Cancer Etiology;cancer initiation;Cell Death;cell growth;Cell Line;Cell model;Cells;Cessation of life;Chromatin;Clear cell renal cell carcinoma;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Complex;Data;Defect;Deposition;design;Diagnosis;Disease;DNA;DNA Repair;Drug Targeting;Epigenetic Process;epigenome;Epithelial Cells;epithelial to mesenchymal transition;experience;Frequencies;Gene Expression;Gene Mutation;Genes;Genetic Transcription;Growth;Health;high reward;high risk;Histone H3;histone methylation;Histones;Human;Immune checkpoint inhibitor;inhibitor;Invaded;Kidney;kidney cell;Laboratories;Link;Lysine;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Messenger RNA;Metabolism;metastatic process;migration;Modeling;Modification;mutant;Mutate;Mutation;Nature;Neoplasm Metastasis;novel;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Process;programs;Proliferating;Proximal Kidney Tubules;Recurrence;Regulator Genes;Renal Carcinoma;Renal Cell Carcinoma;Reporting;response;RNA;RNA methylation;RNA Splicing;Role;senescence;Solid Neoplasm;standard of care;Testing;The Cancer Genome Atlas;therapeutic target;Time;Tissues;transcriptome sequencing;tumor progression;United States;virtual;Work

PROJECT_TITLE: RNA methylation as a novel effector of SETD2 in kidney cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: ABUJA

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: UNIVERSITY OF ABUJA

PHR: I. Project Narrative SPARC-TRAIN will recruit and train a diverse group of 4-6 of talented and highly motivated scholars in Nigeria and Ghana per year to become leaders in hemoglobinopathies and implementation science research utilizing a Team Science approach at UoA, KNUST and UI.

PI_NAMEs: ADEJUMO, PRISCA OLABISI;NNODU, OBIAGELI EUNICE (contact);PEPRAH, EMMANUEL K;SARFO, FRED STEPHEN

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Africa;African;beta Thalassemia;Birth;Cardiovascular system;Chicago;Clinical Research;Country;Dedications;Education;Evidence based intervention;experience;Faculty;Ghana;health equity promotion;Hemoglobinopathies;implementation science;improved outcome;innovation;Institution;Kidney;Mentorship;Morbidity - disease rate;Neurologic;New York;next generation;Nigeria;Outcome;Patient-Focused Outcomes;programs;Public Health;Recording of previous events;recruit;Research;Research Training;Science;Scientist;sickling;Talents;Technology;Time;Training;Training Programs;Translational Research;Translations;Universities;Work

PROJECT_TITLE: Sickle Pan Africa Research Consortium TRAINing (SPARC- TRAIN) Program

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-C (50)]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: KINTAMPO

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: KINTAMPO HEALTH RESEARCH CENTRE

PHR: Project Narrative Forty-one million people die every year from non-communicable diseases (NCDs), accounting for 71% of all global deaths and premature deaths, defined as deaths occurring in persons aged 30-69 years, disproportionately impact low- and middle- income countries (LMICs) like Ghana. There is an urgent need to sustainably build NCD expertise in Ghana for cardiovascular, metabolic and pulmonary disease, with the ultimate goal of training experts who will generate research evidence that can advance public health policy and improve public health. The goal of this training program with experienced faculty from the Kintampo Health Research Centre and University of Ghana School of Public Health and US-partners at Columbia University and Icahn School of Medicine at Mount Sinai is to provide mentored life course NCD and environmental epidemiology training to Ghanaian researchers.

PI_NAMEs: ASANTE, KWAKU POKU (contact);JACK, DARBY ;LEE, ALISON G

PROJECT_TERMS: Acceleration;Accounting;Address;African;aged;burden of illness;Cessation of life;Chronic Disease;cohort;Country;Dedications;Development;Disease;Doctor of Philosophy;Educational workshop;Enrollment;Environmental Exposure;epidemiology study;Evidence based intervention;Ghana;Government;Grant;Graph;Health;Health Transition;Institution;Life;Life course epidemiology;Life Cycle Stages;low and middle-income countries;Master of Science;medical schools;Mentors;mortality;Motion;Persons;Physicians;Policies;postdoctoral investigator;premature;Public Health Schools;repository;Research;Research Infrastructure;Risk Factors;Scientist;Series;Training;Universities;Writing

PROJECT_TITLE: Strengthening capacity for policy-relevant life course epidemiological research in Ghana


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Behavioral and Social Science;Brain Disorders;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Traumatic brain injury (TBI) is a complex neurological condition, and there are currently no FDA- approved treatments to directly treat cognitive deficits. The proposed study will delineate a novel mechanistic role of the epichaperome in the pathophysiology of experimental TBI and use systemic delivery of the epichaperome inhibitor, PU-AD, to evaluate its therapeutic efficacy in attenuating cognitive dysfunction and provide evidence for a role of the epichaperome in TBI pathology.

PI_NAMEs: DIXON, C EDWARD (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Alzheimer associated neurodegeneration;Alzheimer's Disease;Amygdaloid structure;Animals;Attenuated;behavior test;Behavioral;Biochemical;Brain;Brain region;Cancer Model;Cellular Stress;Chronic;Clinical Pathways;clinical translation;Clinical Trials;Cognitive;cognitive ability;Cognitive deficits;cognitive process;combat;Complex;controlled cortical impact;Data;disease phenotype;Dose;FDA approved;Female;Functional disorder;Goals;Heat shock proteins;Heat-Shock Proteins 90;Heat-Shock Response;Hippocampus;Hsc70 protein;Impaired cognition;improved;inhibitor;Injury;Ischemia;Kinetics;Learning;Link;male;Measures;Mediating;Memory;Molecular Chaperones;Molecular Weight;monomer;Nerve Degeneration;neurobehavioral;Neurologic;Neurons;new therapeutic target;Normal Cell;novel;Oral;Outcome;Pathologic;Pathology;Permeability;Pharmacotherapy;Physiological;Production;protein complex;Protein Dynamics;protein expression;protein folding;protein protein interaction;Proteins;Proteomics;proteostasis;Rattus;recruit;response;Role;scaffold;Severities;Stress;Survivors;Therapeutic;therapeutic target;Time;Traumatic Brain Injury;Treatment Efficacy;Western Blotting

PROJECT_TITLE: The epichaperome: A novel therapeutic target for traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Lung;Patient Safety;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: CHILDREN'S MERCY HOSP (KANSAS CITY, MO)

ORG_STATE: MO

PHR: Project Narrative Upper airway obstruction (UAO) in neonates/infants is a potentially life-threatening condition however, currently available modalities for diagnosing UAO are based on subjective assessments and do not provide quantitative measures of airflow disruption or anatomic resolution of the sites of obstruction over the course of the dynamic respiratory cycle. Our goal is to develop an innovative, anatomically precise, patient specific diagnostic modality for UAO via the integration of dynamic upper airway computed tomography scanning with computational fluid dynamics. This work has the potential to revolutionize the diagnosis and treatment decision making process for patients with UAO as well as to significantly improve clinical outcomes by tailoring a treatment plan to the individual patient’s specific patient’s airway pathology.

PI_NAMEs: DAHL, JOHN PATRICK (contact)

PROGRAM_OFFICER_NAME: OKI, NOFFISAT

PROJECT_TERMS: Address;Air Movements;airway obstruction;Airway Resistance;Anatomy;Area;Automobile Driving;awake;Beckwith-Wiedemann Syndrome;Blinded;Blood;Blood Vessels;Breathing;Carbon Dioxide;Caring;Categories;Cerebral Palsy;Clinical;clinical care;Clinical Data;clinical decision-making;Clinical Management;clinical outcome measures;clinical phenotype;clinical practice;Clinical Research;clinical training;cohort;Complex;Computer Analysis;Computer Models;craniofacial;craniofacial microsomia;Data;Death Rate;Decision Making;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic technologies;Disease;Distraction Osteogenesis;Endoscopy;Etiology;experience;Failure;Family;flexibility;Foundations;Functional disorder;Future;Gastrostomy;Goals;Growth;Hospitalization;Image;imaging modality;imaging study;Immobilization;impression;improved;Individual;individual patient;Infant;innovation;Intervention;Jaw;laryngomalacia;Larynx;Length;Life;Liquid substance;Live Birth;Location;Mandibular distraction;Mandibulofacial Dysostosis;Measurement;Measures;Medical;Micrognathism;Modality;Modeling;Modification;mortality;Multivariate Analysis;Nature;neonate;Newborn Infant;novel;novel diagnostics;novel strategies;Obstruction;Obstructive Sleep Apnea;Operative Surgical Procedures;Outcome;Output;particle;Pathology;Patient Care;Patient Selection;Patient-Focused Outcomes;Patients;Phase;physical model;Physicians;Physiological;Polysomnography;pressure;Process;Prone Position;prospective;Prospective cohort;Protocols documentation;Randomized;readmission rates;Recommendation;Reporting;Resistance;Resolution;Resources;respiratory;Respiratory Failure;Retrospective cohort;Risk;Robin bird;Scanning;Secondary to;Severities;Silicones;Site;social interventions;Source;Stenosis;Stratification;Structure;Techniques;three-dimensional modeling;Time;Tongue;Tracheostomy procedure;treatment planning;Tube;validation studies;Velocimetries;vocal cord;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of a Novel Diagnostic Modality for Upper Airway Obstruction via Integrating Dynamic Computed Tomography with Computational Fluid Dynamics

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]