ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Every year, 400,000 million skilled nursing facility (SNF) patients with Alzheimer’s disease and related dementias (ADRD) transfer from SNFs to home and other destinations. Following these transitions, (1) patients with ADRD experience high rates of preventable dementia symptoms and re-hospitalization, with rates highest for Black patients and (2) caregivers of people with ADRD experience high levels of strain and psychological harm. To improve these outcomes and promote health equity, we propose a cluster randomized trial of Connect-Home ADRD, a transitional care intervention for persons with ADRD and their caregivers during care transitions from SNFs to home, assisted living, and long term care.

PI_NAMEs: HANSON, LAURA C;TOLES, MARK P (contact)

PROGRAM_OFFICER_NAME: KEHL, KAREN

PROJECT_TERMS: acceptability and feasibility;access disparities;Acute;acute care;Address;Admission activity;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;arm;Assisted Living Facilities;Award;black patient;Black Populations;Black race;care coordination;care systems;caregiver depression;caregiver strain;Caregivers;Caring;Categories;Clinical;Clinical Trials;Cluster randomized trial;community advisory board;Consolidated Framework for Implementation Research;COVID-19;Data Analyses;Dementia;dementia care;dementia caregiving;deprivation;design;Destinations;Discharge Plannings;Disparity;efficacy testing;Enrollment;Equipment and supply inventories;Equity;experience;Gender;Goals;Health;Health care facility;health equity;health equity promotion;Home;hospital readmission;Hospitalization;improved;improved outcome;indexing;Intervention;intervention effect;Interview;Long-Term Care;Measures;Medical Records;Mental Depression;Methods;Modeling;neglect;Neighborhoods;neuropsychiatric symptom;neuropsychiatry;North Carolina;older adult;Outcome;Participant;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Pilot Projects;Preparation;Protocols documentation;psychologic;Quality of life;Questionnaires;Race;racial disparity;racial diversity;Readiness;Recovery;Research;Safety;Skilled Nursing Facilities;social determinants;Specialist;Surveys;symptom management;Symptoms;System;Telephone;telephone based;Time;treatment as usual;Treatment Efficacy;Work

PROJECT_TITLE: Transitional Care for Skilled Nursing Facility Patients with Alzheimer’s Disease and Related Dementias and their Caregivers: a Cluster Randomized Trial.

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: WORCESTER

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PATHOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: NARRATIVE Recently we found that a unique age-associate B cell population (ABC) population includes a naive IgD B cell population that after influenza infection generates a unique extrafollicular effector B cell response, and that makes the predominant Ab response to influenza in the aged. The naïve IgD ABC contains both T-bet-expressing (about 1/4th) and non-T-bet expressing cells ABC, and during response we find a similar distribution, suggesting two sub-lineages of ABC. We will define the requirements for inducing these subsets of ABC to become effectors and memory and will determine ways to augment vaccines to provide each signal needed to provide protection.

PI_NAMEs: SWAIN, SUSAN L (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: 1918 influenza pandemic;2019-nCoV;Affect;Age;age related;age related decline;aged;Aging;Agonist;Antibodies;Antibody Affinity;Antibody Response;Antibody-mediated protection;Antigens;Attenuated;Autoimmunity;B-Lymphocyte Subsets;B-Lymphocytes;Bone Marrow;CD4 Positive T Lymphocytes;Cell Count;Cell Lineage;Cell Physiology;Cells;Cessation of life;commensal microbes;Complement 3d Receptors;COVID-19;COVID-19 mortality;COVID-19 pandemic;Cytoprotection;Dangerousness;Death Rate;Defect;Development;Dose;Effector Cell;Elderly;emerging pathogen;emerging virus;Equilibrium;Exposure to;Frequencies;Future;future pandemic;Gene Expression Profiling;Generations;Genes;Germ-Free;Goals;Helper-Inducer T-Lymphocyte;Human;Immune;Immune response;Immunity;Immunoglobulin D;Immunoglobulin-Secreting Cells;improved;Individual;Infection;Influenza;influenza infection;influenza virus strain;influenza virus vaccine;influenzavirus;insight;ITGAX gene;Life;Location;Longevity;Lung;lymph nodes;Mediating;Memory;Memory B-Lymphocyte;Messenger RNA;mRNA lipid nano particle vaccine;Mus;Mutation;Nose;novel;novel vaccines;old mice;pandemic influenza;pathogen;Pathway interactions;Phenotype;Plasma;Population;Predisposition;programs;Property;Recurrence;response;Role;Route;Signal Induction;Signal Transduction;Spanish flu;Spleen;Structure of germinal center of lymph node;Surface;T-Lymphocyte;Testing;Time;Tissues;TLR7 gene;translational approach;universal influenza vaccine;universal vaccine;Vaccine Design;vaccine immunogenicity;vaccine platform;vaccine strategy;Vaccines;Variant;Virus

PROJECT_TITLE: How Distinct Age-Associated B Cell Subsets Can Protect the Aged from Influenza

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Lung;Pulmonary Fibrosis

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  While it is well known that idiopathic pulmonary fibrosis has a devastating disease course, approximately 30% of individuals with non-idiopathic pulmonary fibrosis interstitial lung disease will develop progressive pulmonary fibrosis, with an overall poor survival worse than many cancers. At the current time, there is no ability to distinguish what patients are at highest risk of progressive pulmonary fibrosis, a pressing and unmet medical need. The purpose of this study is to use advanced imaging techniques to predict which individuals will develop progressive pulmonary fibrosis with the goal of enabling treatment plans to be tailored accordingly.

PI_NAMEs: MONTESI, SYDNEY  (contact)

PROGRAM_OFFICER_NAME: GOMEZ, CHRISTIAN RENE

PROJECT_TERMS: Affect;antifibrotic treatment;Binding;Blood Vessels;Caring;Chest;Cicatrix;Clinical;Clinical assessments;Clinical Trials;cohort;Collagen;Collagen Type I;contrast enhanced;cost;Data;Deposition;Development;Diagnosis;diagnostic accuracy;Disease;Disease Progression;Early identification;experience;Extracellular Space;Fibrosis;fibrotic interstitial lung disease;Goals;Guidelines;High Resolution Computed Tomography;high risk;idiopathic pulmonary fibrosis;Image;imaging approach;Imaging Techniques;Imaging technology;Immunosuppression;improved;improved outcome;Individual;inhibitor;innovation;interest;Interstitial Lung Diseases;Longitudinal, observational study;Lung;lung imaging;lung injury;Lung Transplantation;Magnetic Resonance Imaging;Malignant Neoplasms;Measurement;Measures;Medical;Modality;mouse model;nintedanib;novel;Patient Care;Patient-Focused Outcomes;Patients;Perfusion;personalized care;Positron-Emission Tomography;prognostication;Progressive Clinical Course;Progressive Disease;prospective;Pulmonary Fibrosis;pulmonary function;pulmonary function decline;Pulmonary function tests;Respiratory Signs and Symptoms;Risk;side effect;Specificity;standardize measure;Techniques;Technology;Therapeutic;Therapeutic Intervention;Time;tissue injury;tool;treatment planning;treatment response;United States;uptake;Validation

PROJECT_TITLE: Advanced Imaging for Pulmonary Fibrosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-P (03)]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: Principal Investigator: Facundo M. Fernández – Deep Ovarian Cancer Metabolomics  High-grade serous ovarian cancer is the most common and deadliest type of ovarian cancer; it is diagnosed mostly at an advanced stage at which the cancer has already spread beyond the ovary or the fallopian tube, to the abdominal cavity; advanced-stage diagnosis inevitably causes high mortality. In this project, we propose to study molecular changes in metabolites and lipids associated with early disease in mouse models that closely mimic human disease in at-risk patients, look for cancer biomarkers in “mock” Pap samples and develop new tools to annotate metabolites that track with ovarian cancer progression.

PI_NAMEs: FERNANDEZ, FACUNDO MARTIN (contact);KIM, JAEYEON ;SKUBITZ, AMY PATRICE

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Abdominal Cavity;Accounting;Animal Model;Animals;annotation  system;Anti-Progestin;Biological;Biological Markers;biomarker discovery;biomarker panel;BRCA mutations;BRCA1 gene;BRCA1 Mutation;Breast;CA-125 Antigen;cancer biomarkers;cancer cell;Cancer Control;Cancer Etiology;Cancer Patient;cancer risk;cancer subtypes;Carcinoma;Cessation of life;Characteristics;Clear Cell;Clinical;Collaborations;Coupled;Detection;Development;Diagnosis;Disease;Disease Progression;Early Diagnosis;Endogenous Factors;Environment;Etiology;Exhibits;experimental study;explainable machine learning;Female Genital Diseases;Fingerprint;Gene Expression;Genetic;Genomics;Germ Lines;high risk;high risk population;High-Risk Cancer;Histologic;Human;human disease;Hybrids;improved;Indiana;Individual;Intrinsic factor;ion mobility;ion source;Knockout Mice;lipidome;Lipids;Liquid Chromatography;liquid chromatography mass spectrometry;Liquid substance;machine learning prediction;Malignant Breast Neoplasm;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Measurement;Mediating;medical schools;Metabolic;metabolic phenotype;Metabolism;metabolome;metabolomics;Methods;Minnesota;Molecular;mortality;mouse model;Mucinous;multiple omics;Mus;mutant;Mutation;mutation carrier;nano;nanoelectrospray;Neoplasm Metastasis;Outcome;Ovarian;Ovarian Ablation;Ovarian hormone;Ovarian Tissue;Ovary;Pap smear;Pathogenicity;Patients;Pattern;Peritoneal;Phenotype;pi bond;potential biomarker;Predictive Value;Prevention;Primary Neoplasm;Principal Investigator;Probability;Progesterone;protein biomarkers;Reporting;reproductive;Research;Risk;Risk Management;risk prediction;Role;Sampling;screening;Screening for Ovarian Cancer;Sensitivity and Specificity;Serous;Serum;Signal Transduction;Site;specific biomarkers;Speed;Structure;Survival Rate;Symptoms;System;tandem mass spectrometry;Time;Tissue imaging;Tissues;tool;trait;Translating;Transvaginal Ultrasound;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor progression;Universities;Vaginal Douching;WFDC2 gene;Woman;Work

PROJECT_TITLE: Deep Ovarian Cancer Metabolomics

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Genetics;Nutrition;Obesity

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative A central function of fat cells is to store energy when food is abundant and release energy during fasting. When this cycle is disrupted fat tissue dysfunction and metabolic disease ensues, including diabetes mellitus. This project will study a new molecular pathway responsible for the control of fat storage and release in adipocytes and whether it is critical in states of metabolic stress, including fasting, obesity, and aging.

PI_NAMEs: STEINHAUSER, MATTHEW  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Acid Lipase;Adipocytes;Adipose tissue;Aging;Applications Grants;Attenuated;Autophagocytosis;Biogenesis;Biological;Biological Assay;Cardiometabolic Disease;Cells;Collaborations;combinatorial;Data;Diabetes Mellitus;diet-induced obesity;Digestion;Disease;disorder risk;endoplasmic reticulum stress;energy balance;epigenomics;Equilibrium;Family;Fasting;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;feeding;Food;Functional disorder;Genes;Genetic;Genetic Models;Genetic Transcription;genetic variant;genome-wide;Genomics;Glycerol;Head;high resolution imaging;Homeostasis;Hormones;Human;Hypertrophy;Hypoxia;Impairment;in vivo;Inflammation Mediators;innovation;Inpatients;Insulin;Insulin Resistance;insulin sensitivity;Knock-out;Knockout Mice;Label;Laboratories;Lead;Link;Lipase;lipid metabolism;Lipids;Lipolysis;loss of function;Lysosomes;Maps;mass spectrometric imaging;Measures;Mediating;member;Membrane Lipids;Metabolic;Metabolic Diseases;metabolic phenotype;Metabolic stress;metabolomics;Methods;Microscopy;Modeling;Molecular;multimodality;multiple omics;Mus;Nonesterified Fatty Acids;novel;Obesity;Organelles;Pathologic;Pathway interactions;pharmacologic;Physiological;preservation;programs;Regulation;Reporter;Role;Signal Transduction;Source;stable isotope;standard measure;stressor;Structure;Testing;Tissues;Tracer;Transcript;transcription factor;transcriptomics;Triglycerides

PROJECT_TITLE: Defining the molecular regulation and physiological role of a novel lysosomal mechanism of adipocyte lipolysis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Digestive Diseases - (Gallbladder);Immunotherapy;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: A thorough understanding of the underlying biology of intrahepatic cholangiocarcinoma (iCCA) is critical for the development of effective therapies for this highly lethal form of hepatobiliary cancer. Our preliminary studies have identified a novel B7-H4-regulated signaling axis that profoundly alters the desmoplastic reaction, a prominent feature of this cancer type, and contributes to tumor growth. We propose to elucidate the molecular mechanisms underpinning this entirely novel tumor-stromal cross-talk and advance our understanding of how to treat patients afflicted by iCCA and possibly other B7-H4-driven malignancies.

PI_NAMEs: SIA, DANIELA  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Ablation;Artificial Intelligence;Artificial Intelligence platform;Attenuated;Bile Duct Carcinoma;Bile Duct Neoplasms;Binding;Biology;Cancer Cell Growth;cancer type;Cell Line;Cell membrane;cell motility;Cell Nucleus;cell type;Cells;chemotherapy;Cholangiocarcinoma;Classification;Clinical;clinically relevant;Collagen;Collagen Fiber;Collection;Complex;CRISPR/Cas technology;Cytoplasm;Data;DDR2 gene;Deposition;Desmoplastic;Development;Diagnosis;Docking;effective therapy;efficacy evaluation;Endoplasmic Reticulum;experimental study;Extracellular Matrix;Fiber;Fibroblasts;Genes;Genetic;genetic manipulation;Goals;Growth;Heat-Shock Proteins 90;hepatobiliary cancer;Human;Immune;immune cell infiltrate;immune checkpoint;Immunogenomics;improved;improved outcome;In Vitro;in vivo;inhibitor;Injections;innovation;insight;Intrahepatic Cholangiocarcinoma;Knowledge;Ligands;liver cancer model;MADH2 gene;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Modeling;Molecular;molecular phenotype;Monoclonal Antibodies;mouse model;Mus;Neoplasm Metastasis;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Organoids;Outcome;overexpression;Pathway interactions;Patients;PD-L1 blockade;Pharmaceutical Preparations;pharmacologic;Phenotype;Play;Positioning Attribute;programmed cell death ligand 1;programmed cell death protein 1;Proteins;receptor;Reporting;Research;response;Role;Sampling;Shapes;Signal Transduction;single cell technology;single-cell RNA sequencing;Sleeping Beauty;standard of care;Stromal Neoplasm;Structure;Survival Rate;T-Lymphocyte;Tail;Testing;Therapeutic;Transforming Growth Factor beta;Translating;Transposase;treatment choice;tumor;tumor growth;Tumor Promotion;Tumor-infiltrating immune cells;Veins;VTCN1 gene;Work

PROJECT_TITLE: Dissecting a novel tumor-promoting axis in cholangiocarcinoma

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Prevention

PHR: In this grant, we will overcome the high cost and inefficacies of colonoscopy for cancer screening by developing and validating new in vivo microscopic imaging technologies for detecting and treating cancer precursors called colorectal adenomas. Successful completion of this research will significantly improve colorectal cancer screening by enabling higher adenoma detection rates, and by providing a less invasive screening tool that can automatically detect and treat adenomas at the point of care without requiring sedation.

PI_NAMEs: TEARNEY, GUILLERMO J (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: 3-Dimensional;Ablation;Acceleration;Accounting;Address;adenoma;Adverse event;Agreement;Anatomy;Anesthesia procedures;Anus;Back;Benign;capsule;Cecum;Classification;classification algorithm;Clinical;Clinical Research;clinical translation;Collimator;Colon;Colonic Adenoma;Colonic Polyps;Colonoscopes;Colonoscopy;Colorectal;Colorectal Adenoma;Colorectal Cancer;colorectal cancer prevention;colorectal cancer screening;Conscious Sedation;cost;Data;design;Detection;Development;Devices;Diagnosis;diagnostic accuracy;Diameter;Discrimination;Disparity;Endoscopes;Excision;Family suidae;Fiber;follow-up;Forcep;Future;Grant;Health;Health Care Costs;Histologic;Histopathology;Human;Image;Imaging Device;imaging probe;imaging system;Imaging technology;improved;in vivo;in vivo evaluation;in vivo imaging;Incidence;innovative technologies;irradiation;Large Intestine;Lasers;Lateral;Lead;Length;Lesion;machine learning algorithm;Malignant - descriptor;Malignant Neoplasms;meter;microendoscopy;microscopic imaging;Modeling;Motion;Mucous Membrane;neoplastic;novel;Optical Coherence Tomography;Optics;Organ;Patients;Phase;point of care;polyposis;Polyps;population based;Positioning Attribute;primary endpoint;Procedures;Questionnaires;Recovery;Rectum;Research;Resected;Resolution;Retinal blind spot;Rotation;Safety;safety and feasibility;safety testing;Scanning;screening;Screening for cancer;Screening procedure;secondary endpoint;Sedation procedure;Silicones;Speed;standard of care;success;System;Techniques;Technology;Testing;Time;Tissue imaging;Tissues;Variant;Visualization

PROJECT_TITLE: Colorectal Cancer Screening with Optical Coherence Tomography

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: AR

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Prevention;Rehabilitation

ORG_CITY: SAINT LOUIS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Post-traumatic joint contracture (PTJC), a common clinical problem following injury that leads to permanent stiffness and debilitating impairment, is especially challenging in the elbow because of high susceptibility and a lack of adequate treatment options. This study will use a preclinical animal model and machine learning-based computational tools to optimize physical therapy strategies and anti-inflammatory drug treatments for elbow PTJC. The long-term result of this work will be to elucidate key concepts and fundamental principles that optimize rehabilitation/treatment following injury and lead to decreased occurrence/impact of elbow PTJC.

PI_NAMEs: LAKE, SPENCER PARK (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Address;Animal Model;Anti-Inflammatory Agents;Articular Range of Motion;Biological;Biological Response Modifier Therapy;Biology;capsule;Caring;cell mediated immune response;Cells;Classification;Clinical;clinical implementation;clinical practice;Clinical Protocols;Clinical Treatment;Cluster Analysis;computerized tools;Contracts;Contracture;Data;Data Analyses;Development;disability;Elbow;Engineering;Etiology;Evaluation;Fibrosis;Functional disorder;Future;Guidelines;healing;Human;Hypertrophy;Image;Image Analysis;Immobilization;Immune;immunomodulatory therapies;Impairment;improved;improved outcome;Individual;Inflammation;inflammatory modulation;Inflammatory Response;Injury;innovation;Intervention;joint function;joint injury;Joints;Ligaments;Link;Machine Learning;machine learning algorithm;Mediating;Motion;Multimodal Imaging;multimodal learning;multimodality;novel;Outcome;Pattern;Pharmacotherapy;Phase;Physical Rehabilitation;Physical therapy;Population;Positioning Attribute;pre-clinical;Pre-Clinical Model;preclinical evaluation;Predisposition;preservation;prevent;Prevention;Prevention strategy;Protocols documentation;Rehabilitation therapy;response;Signal Transduction;spatial relationship;spatiotemporal;success;synergism;T-Lymphocyte;targeted treatment;Therapeutic;Tissues;tool;treatment optimization;treatment strategy;Work

PROJECT_TITLE: Preclinical evaluation of physical and biological interventions to reduce post- traumatic joint contracture

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Hematology;Rare Diseases;Women's Health Research

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Although proteasome inhibitors are currently used in the clinic against Multiple myeloma, this approach alone is insufficient for sustaining long-term remission in patients. DDI2 protease plays a major role in cancer cell survival during proteasome inhibition therapy. This proposal aims to characterize inhibition of DDI2 protease, a strategy that can be used to increase the efficacy of proteasome inhibitors.

PI_NAMEs: KLEIGER, GARY L.;RADHAKRISHNAN, SENTHIL KUMAR  (contact);SERGIENKO, EDUARD A.

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Antibodies;Antibody Specificity;Autophagocytosis;Biochemical;Biological;biological adaptation to stress;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;cancer cell;Cell Line;Cell Survival;Cells;Clinic;comparison control;CTSD gene;Data;Disease remission;Dominant-Negative Mutation;Engineering;expectation;experimental study;Generations;Genes;Genetic Transcription;Goals;high throughput screening;Image;Immunofluorescence Immunologic;inhibitor;knock-down;Knock-out;knockout gene;Luciferases;Malignant Breast Neoplasm;MDA MB 231;Measures;Mediating;Messenger RNA;Methods;Monoclonal Antibodies;multicatalytic endopeptidase complex;Multiple Myeloma;mutant;Noise;Normal Cell;Output;parent grant;Pathway interactions;Patients;Peptide Hydrolases;Pharmacotherapy;Play;Process;programs;promoter;Protease Domain;Protease Inhibitor;Proteasome Inhibition;Proteasome Inhibitor;proteotoxicity;Publications;Quantitative Reverse Transcriptase PCR;Reader;Recovery;Reporter;Reproducibility;Research Design;Research Project Grants;response;Role;scaffold;Signal Transduction;Site;Small Interfering RNA;small molecule inhibitor;stable cell line;Stress;Structure-Activity Relationship;Testing;time use;transcription factor;triple-negative invasive breast carcinoma;vector control;ward;Western Blotting;Work;Xenograft Model

PROJECT_TITLE: Identification of small molecule inhibitors of the DDI2 protease

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE The research proposed here is directed towards understanding the protein machinery responsible for the biogenesis of the outer membrane of Gram-negative bacteria, a structure that is essential for their survival. A better understanding of the protein components of this machinery and the processes in which they are involved may lead to the discovery of inhibitors that could ultimately be developed for therapeutic uses to treat Gram- negative infections.

PI_NAMEs: KAHNE, DANIEL  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affect;Affinity;Antibiotic Resistance;Antibiotics;Behavior;beta barrel;Binding;Biochemical;biochemical tools;Biogenesis;Biological Assay;Cell Death;Cell Physiology;Cells;Complex;Cryoelectron Microscopy;design;Dissociation;experimental study;Exposure to;Failure;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Health;Human;Hydrolysis;In Vitro;in vivo;Individual;Infection;inhibitor;Knowledge;Lipopolysaccharides;Mass Spectrum Analysis;Measures;Membrane;membrane assembly;membrane biogenesis;Membrane Proteins;Molecular Structure;Movement;Pathway interactions;Peptide Hydrolases;periplasm;Phospholipids;premature;Process;protein complex;protein folding;protein protein interaction;Proteins;proteoliposomes;Pump;Quality Control;Regulation;Research;Site;Site-Directed Mutagenesis;Structure;Testing;therapeutic target;Therapeutic Uses;Work

PROJECT_TITLE: Outer Membrane Biogenesis: New Antibiotic Targets

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative This proposed research will study the role of neuroactive steroids in modulation of voltage-gated calcium channels and the role of these channels in acute and chronic pain conditions, as well as excitability and synaptic transmission of dorsal horn neurons of spinal cord. We anticipate that this approach will ultimately lead to better treatments for acute and chronic pain conditions after surgical incision of skin and deep soft tissues with minimal potentials for serious side effects and drug abuse.

PI_NAMEs: JEVTOVIC-TODOROVIC, VESNA  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;Acute Pain;addiction;Analgesics;analog;Androstanols;Anesthetics;Animals;antinociception;aqueous;Behavior;Calcium;Calcium Channel;Cells;Chronic;chronic pain;chronic painful condition;Clinic;clinically relevant;Cocaine;cognitive function;Conduction Anesthesia;Constipation;Development;Disease;dorsal horn;Dose;Drug abuse;Drug Kinetics;Exposure to;follow-up;Future;General anesthetic drugs;Grant;Heroin;Hyperalgesia;hypnotic;Impaired cognition;In Vitro;in vivo;inhibitor;Injectable;Injections;Injury;innovation;intraperitoneal;Knock-out;Knockout Mice;Knowledge;Light;Link;Local Anesthetics;Mechanics;Mediating;Medical;Metabolic Pathway;Metabolism;Modality;Modeling;Morphine;Mus;Narcotics;Neurologic;neuronal excitability;Neurons;neurosteroids;Nociception;Nociceptors;novel;novel therapeutics;Numbness;Operating Rooms;Operative Surgical Procedures;Opioid;opioid abuse;Opioid Analgesics;optogenetics;Outcome;overdose death;Pain;Pain management;pain model;pain perception;pain processing;pain relief;patch clamp;Pathway interactions;Perioperative;Peripheral;Persons;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;positive allosteric modulator;Posterior Horn Cells;Postoperative Pain;Postoperative Period;preclinical study;presynaptic neurons;Presynaptic Terminals;prevent;Property;Protein Isoforms;receptor;Research;response;Risk;Rodent Model;Role;sciatic nerve injury;sedative;Sensory Motor Performances;sex;side effect;Site;Skin;soft tissue;Solubility;Spinal;Spinal Cord;Spinal Ganglia;spontaneous pain;Surgical incisions;Synapses;Synaptic Transmission;Synaptic Vesicles;Testing;tissue injury;Tissues;Transgenic Mice;United States;United States National Center for Health Statistics;Urinary Retention;Ventilatory Depression;voltage;Wild Type Mouse;Work

PROJECT_TITLE: Novel neurosteroid anesthetics and perioperative analgesia

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Arthritis;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

PHR: NARRATIVE  Type I interferons are a group of proteins known to interfere with viral replication but can also shape the host immune response. Studying a virus known as Chikungunya virus, which is a human pathogen that causes febrile arthritis, we have found that interferons play both beneficial and harmful roles by acting on skin and muscle cells. Understanding how interferons signal on these different stromal cell populations throughout the course of infection will improve our understanding of tissue-specific immune responses that are mounted during vector-mediated infectious diseases and in response to vaccines.

PI_NAMEs: LENSCHOW, DEBORAH J (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Address;Alpha Virus;Alphavirus Infections;Arthritis;Arthritogenic;Blocking Antibodies;Bone Marrow;Brazil;Cell Line;cell type;Cells;Cellular Tropism;chemokine;chikungunya infection;Chikungunya virus;Chimera organism;Chondrocytes;Clinical;Communicable Diseases;Country;Culicidae;cytokine;Data;Dermal;Disease;Disease Outbreaks;Endothelial Cells;Endothelium;Fever;Fibroblasts;foot;Gene Expression;Guatemala;Health;Hematopoietic;human pathogen;IFNAR1 gene;Immune;Immune response;improved;in vivo;India;Infection;Innate Immune Response;Interferon alpha;Interferon Type I;Interferons;Lead;Mediating;Messenger RNA;mouse genetics;Mus;Muscle;Muscle Cells;Myositis;Outcome;outcome disparities;Paraguay;Pathogenesis;Pericytes;Phenotype;Platelet-Derived Growth Factor alpha Receptor;Play;Population;preservation;Production;Property;Proteins;recruit;Research;Research Proposals;response;Role;Shapes;Signal Transduction;single nucleus RNA-sequencing;Site;Skin;Stromal Cells;Swelling;Techniques;Technology;Testing;Thailand;Tissues;transcriptome sequencing;transmission process;tumor microenvironment;type I interferon receptor;Vaccination;Vaccines;vector;Vector-transmitted infectious disease;Viral;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Determining the impact of stromal cell-mediated type I IFN signaling on alphavirus pathogenesis

STUDY_SECTION: VPI

STUDY_SECTION_NAME: Viral Pathogenesis and Immunity Study Section [VPI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Contraception/Reproduction;Infectious Diseases;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Networking and Information Technology R&D (NITRD);Patient Safety;Women's Health Research;Wound Healing and Care

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative In this study, we will prospectively enroll 6,000 women who delivered via cesarean in Rwanda, Ghana, and Mexico and collect visible and thermal wound images and clinician SSI diagnoses on postoperative day (POD) 10 to: a) evaluate the generalizability of infection prediction algorithms developed from data on visible image and thermal images collected in Rwanda, and b) retrain the algorithms to predict SSIs across diverse skin tones. We will follow 1,200 women to POD20 and POD30 to explore the importance of following women past POD10 and evaluate for the likelihood of POD10 images predicting later diagnosed SSIs. This research will inform strategies to accurately predict SSIs after cesarean delivery among women of varying skin tones.

PI_NAMEs: HEDT-GAUTHIER, BETHANY  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: accurate diagnosis;Africa South of the Sahara;algorithm training;Algorithms;Area Under Curve;Cesarean section;Clinical;Clinical assessments;Clinical Data;clinical examination;Community Health Aides;Complication;convolutional neural network;Country;Data;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic tool;Enrollment;Environment;Evaluation;Feasibility Studies;follow-up;General Practitioners;Ghana;Goals;Health Technology;Home;Image;Image-Guided Surgery;improved;Infection;infection rate;Latin America;low and middle-income countries;Machine Learning;Maternal Health Services;maternal morbidity;Maternal Mortality;maternal outcome;Medical;Mexico;mHealth;mobile application;Monitor;Morbidity - disease rate;mortality;Operative Surgical Procedures;Outcome;Patients;Performance;Population Heterogeneity;postcesarean section;Postoperative Period;prediction algorithm;Pregnancy;Prevalence;Procedures;programs;Property;prospective;Research;Risk Reduction;Rural;rural area;rural setting;Rwanda;Science;Sensitivity and Specificity;Site;Skin;Specificity;Surgical Wound Infection;Telemedicine;Time;tool;Training;transfer learning;Update;Vaginal delivery procedure;Visible Radiation;Woman;Work;wound;wound care

PROJECT_TITLE: Image-based algorithms for remote cesarean surgical site infection diagnoses in diverse populations

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Chronic Pain;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: Project Narrative Chronic pain is a serious problem that affects 1 in 3 Americans and one of its less understood symptoms is spontaneous pain. Our research has shown, after nerve injury, spontaneously active “cluster firing” sensory neurons and neuropathic spontaneous pain can be triggered by local mechanical movement of the blood vessels in the sensory ganglia. Understanding the causal mechanism behind vascular movement-evoked spontaneous pain could help lead to a new understanding about spontaneous pain and possibly to novel treatment targets.

PI_NAMEs: ZHANG, JUN-MING  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: Adrenergic beta-Antagonists;Adrenergic Receptor;Affect;Afferent Neurons;American;angiogenesis;Angiotensin II;Axon;behavior measurement;Blood Vessels;chronic pain;Clinical;Elements;Environment;experimental study;Fiber;genetic approach;Imaging Techniques;in vivo;in vivo calcium imaging;inflammatory pain;knock-down;Lead;Mechanics;Mechanoreceptors;Mediating;Microscopy;Movement;Mus;Muscle;nerve injury;neuronal excitability;Neuronal Injury;Neurons;Neuropathy;Nociceptors;Normal tissue morphology;novel;Pain;pain behavior;pain model;painful neuropathy;Peripheral nerve injury;pharmacologic;Phenylephrine;Piezo 2 ion channel;promoter;Rattus;receptor;Research;Risk Factors;Role;Sensory;Sensory Ganglia;Skin;Spinal Ganglia;spontaneous pain;Symptoms;Testing;Therapeutic;Universities;vasoconstriction;Vasoconstrictor Agents;Vasodilation;Vasodilator Agents

PROJECT_TITLE: Neuron vasculature interactions in pain

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Allergic Rhinitis (Hay Fever);Asthma;Food Allergies;Genetics;Health Effects of Indoor Air Pollution;Lung;Prevention

PHR: NARRATIVE Immune tolerance to allergens in desirable to prevent allergic diseases such as asthma. We have established a model of immune tolerance in early life which is dependent on dendritic cells (DCs) and requires mitochondrial H2O2 although the molecular mechanisms that promote tolerogenic DCs are not known. We propose a novel mechanism of inducing airway immune tolerance to allergens in which expression of the molecule Marcksl1 in DCs plays an important role in both mice and humans. The results of our proposed work will identify Marcksl1 as a marker of protection from allergic asthma whose maintenance in DCs from early life would protect from disease development in later life.

PI_NAMEs: RAY, ANURADHA  (contact);RAY, PRABIR

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Abbreviations;Address;Adverse reactions;airborne allergen;airway inflammation;Allergen Immunotherapy;Allergens;Allergic Disease;Allergic rhinitis;Animal Model;animal model development;antigen-specific T cells;Antigens;Apoptosis;Asthma;asthmatic;Atopic Dermatitis;Biopsy;catalase;cell motility;Cells;Cessation of life;Clinical Trials;Data;Dendritic Cells;desensitization;Development;Disease;Disease susceptibility;Dose;Enzymes;Equilibrium;Exposure to;Extrinsic asthma;fatty acid oxidation;follow-up;Food Hypersensitivity;FOXP3 gene;Future;Gene Expression;gene network;genetic approach;House Dust Mite Allergens;Household;Human;human data;Hydrogen Peroxide;hypersensitivity desensitization;Immune Tolerance;Immunological Models;Impairment;Individual;Inflammation;Inhalation;ITGAX gene;Knowledge;late life;Life;Lung;lymph nodes;Maintenance;MARCKS-related protein;Mediating;Memory;metabolic abnormality assessment;Metastatic Neoplasm to Lymph Nodes;migration;Mitochondria;Modeling;Molecular;Mus;Newborn Infant;novel;old mice;Ovalbumin;overexpression;Pathway interactions;Play;prevent;Production;programs;Publishing;Pyroglyphidae;Reactive Oxygen Species;Regulatory T-Lymphocyte;Reporting;Rest;Role;Safety;Series;single-cell RNA sequencing;Source;T cell response;T-Lymphocyte;Techniques;Time;Tissues;Transgenic Mice;Translations;Wild Type Mouse;Work

PROJECT_TITLE: Mechanisms of Antigen-Induced Tolerance in the Lung

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Aging;Arthritis;Bioengineering;Biomedical Imaging;Chronic Pain;Clinical Research;Machine Learning and Artificial Intelligence;Osteoarthritis;Pain Research;Physical Activity;Physical Rehabilitation;Rehabilitation

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Knee osteoarthritis is a common and debilitating disease that causes joint pain and eventually leads to joint replacement surgery but has an unknown cause and no available treatments. Exercising lower-limb muscles is one of the only recommended options to manage joint pain, but the relationship between the changes in muscle and the changes in osteoarthritis pain and disease progression are unknown. Thus, we will develop new magnetic resonance imaging acquisition and analysis techniques of both lower limbs to better understand the changes that occur in the muscles and the knee during exercise training, with a view towards better future interventions to manage and treat osteoarthritis.

PI_NAMEs: CHAUDHARI, AKSHAY ;GOLD, GARRY E (contact)

PROGRAM_OFFICER_NAME: LIU, GUOYING

PROJECT_TERMS: Acceleration;Acute;Adult;Affect;Aging;Area;Arthralgia;automated image analysis;Bilateral;Biochemical;Biological Markers;Biomechanics;bone;Cartilage;cartilage degradation;Cellular Phone;Clinic;Clinical;Complex;Data;data space;deep learning;Degenerative polyarthritis;design;Development;Diffusion Magnetic Resonance Imaging;disability;Disease;Disease Progression;Environment;Etiology;Exercise;exercise intervention;exercise training;Financial Hardship;Future;Gait;Goals;Health;Human;Image;imaging biomarker;Imaging Device;improved;individualized medicine;innovation;insight;Intervention;joint function;joint loading;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;knee replacement arthroplasty;lifestyle intervention;limb injury;Limb structure;Longitudinal Studies;loss of function;Lower Extremity;Magnetic Resonance Imaging;Maps;Measures;Meniscus structure of joint;Methods;minimally invasive;Modeling;Morphology;Muscle;muscle form;Muscle function;muscle strength;Muscular Atrophy;muscular structure;Musculoskeletal;neural;novel;Older Population;Operative Surgical Procedures;Orthopedics;osteoarthritis pain;Outcome;Pain;Pain management;pain relief;Patient-Focused Outcomes;Patients;personalized intervention;Pharmaceutical Preparations;Physical therapy;Physiology;pressure;prognostication;programs;Protocols documentation;quantitative imaging;Recommendation;Rehabilitation therapy;Replacement Arthroplasty;Research;Resolution;response;Sampling;Scanning;self supervised learning;Shapes;soft tissue;strength training;Structure;Synovial Membrane;Techniques;Testing;Therapeutic Intervention;Thigh structure;Time;Tissues;tool;Training;training data;Traumatic Arthropathy;treatment strategy;Validation;Vendor;Visual;Walking;walking intervention

PROJECT_TITLE: Designing Novel MR Imaging Tools to Quantify Lower-Limb Exercise Adaptations in Knee Osteoarthritis


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Learning is an elemental function of all brains that enables animals to adapt to an ever-changing environment. The focus of this proposal is to understand the fundamental mechanisms of neuronal connectivity that allow brains to learn efficiently. This project has the potential to uncover a fundamental design principle that fine-tunes the ability of the brain to form certain associations more readily than others, thus potentially accounting for well- known cognitive biases.

PI_NAMEs: CARON, SOPHIE  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Biased randomness: a fundamental connectivity mechanism for associative brain centers.

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Genetics;Mental Health;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Narrative Astrocytes are the most abundant cell type in the adult human brain, mediating vital functions including myelination, axonal guidance, synaptogenesis, and maintenance of the blood-brain barrier. While defects in their function are implicated in a wide range of diseases, including cancers as well as aging, how the diversity of astrocytes is generated in the brain during development remains unknown. The proposal will lead to a fundamental mechanistic insight into the development of human astrocytes and lay the foundation for uncovering the causes and devising new treatment strategies for astrocyte-related human diseases.

PI_NAMEs: RAMANATHAN, SHARAD  (contact)

PROGRAM_OFFICER_NAME: PANCHISION, DAVID M

PROJECT_TERMS: Address;Adult;Aging;Antibodies;ASCL1 gene;astrocyte progenitor;Astrocytes;axon guidance;Bar Codes;Blood - brain barrier anatomy;Brain;Calcium;CD44 gene;cell cortex;Cell Differentiation process;cell type;Cells;Characteristics;Chemicals;comparative;Computer Analysis;Computing Methodologies;CRISPR interference;Cryoultramicrotomy;Data;Data Analyses;Defect;Development;Disease;Dissociation;Embryonic Development;embryonic stem cell;Epilepsy;Epileptogenesis;ES05;Ethics;Exhibits;experimental study;fetal;Fetal Tissues;fetus cell;First Pregnancy Trimester;FOS gene;FOSL1 gene;Foundations;Gene Expression;gene regulatory network;Generations;Genes;Genetic;gliogenesis;Glutamate Transporter;Glutamates;Glycogen;Goals;HMGA1 gene;Human;human data;human disease;human embryonic stem cell;human embryonic stem cell line;human fetus tissue;Huntington Disease;Image;In Vitro;in vitro Model;in vivo;in vivo evaluation;insight;Ischemic Stroke;JUN gene;JUNB gene;knock-down;Lead;Libraries;Macaca;Maintenance;Malignant Neoplasms;Maps;Measures;Mediating;Methods;model organism;Modeling;Monitor;Morphology;multipotent cell;Mus;myelination;neocortical;Neurodegenerative Disorders;Neuroepithelial;neuroepithelium;neurogenesis;Neuroglia;Neurons;NFIA gene;novel;novel therapeutic intervention;Oligodendroglia;Pathway interactions;Pattern;Permeability;postnatal;Primates;Production;progenitor;Proliferating;Prosencephalon;Radial;Role;Second Pregnancy Trimester;Series;Signal Pathway;Signal Transduction;single cell analysis;small molecule;SOX6 gene;spatiotemporal;Stains;stem cell fate;stem cells;synaptogenesis;System;Techniques;Time;Tissues;Transcript;transcription factor;transcriptomics;Viral;Work

PROJECT_TITLE: Understanding glial fate restriction in humans

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Precise understanding of the central mechanisms for postoperative pain is needed to develop novel analgesics and address the current opioid epidemic. The proposed research tests the hypothesis that disrupted inputs to the prefrontal regions of the brain contributes to symptoms of chronic postoperative pain. Further, we aim to define how drugs or compounds such a ketamine and oxytocin can repair these circuit disruptions to treat postoperative pain.

PI_NAMEs: WANG, JING  (contact)

PROJECT_TERMS: Acute Pain;acute symptom;Address;Affective;Analgesics;analytical tool;Anatomy;Anterior;antinociception;Area;Brain;Brain region;Calcium;Chronic;chronic pain;cingulate cortex;Data;design;Development;Down-Regulation;Epidemic;experimental study;extracellular;Funding;glutamatergic signaling;Glutamates;Goals;Graph;hippocampal pyramidal neuron;Human;Hyperactivity;Hypothalamic structure;Image;Impairment;improved;in vivo;in vivo calcium imaging;innovation;insight;Ketamine;Label;Link;Literature;Machine Learning;Maps;Mediating;Mediator;Modeling;Morbidity - disease rate;nerve injury;neural;Neurons;neuroregulation;Neurosciences;Nociception;nociceptive response;Nociceptive Stimulus;non-opioid analgesic;novel;novel therapeutics;Nucleus Accumbens;Operative Surgical Procedures;opioid epidemic;opioid use;optogenetics;Output;Oxytocin;Pain;pain behavior;pain inhibition;Pain management;pain model;pain relief;pain symptom;painful neuropathy;paraventricular nucleus;Patients;Persistent pain;persistent symptom;Pharmaceutical Preparations;Pilot Projects;Play;Postoperative Pain;Postoperative Period;postsynaptic;Prefrontal Cortex;presynaptic;presynaptic neurons;Publishing;Rattus;Regulation;repaired;Research;response;Rest;Rodent;Role;Sensory;Somatosensory Cortex;spared nerve;Surgical incisions;Symptoms;Synapses;Synaptic plasticity;System;Techniques;Testing;Therapeutic;therapeutic target;Time;tool;Work

PROJECT_TITLE: Central glutamate signaling in postoperative pain regulation - Renewal 2


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Gene Therapy;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: Project Narrative Multiple myeloma is an incurable malignancy of plasma cells and, patients who have a relapse after BCMA- directed therapies have limited treatment options. Our studies will provide useful information addressing the role of targeting novel antigens such as SEMA4A in patients with relapse after BCMA therapy and the role of combinatorial therapies to target low-antigen-density reservoirs of relapse and induce deeper and longer durations of response. Quantitative antigen density profiling in malignant and normal cells will inform optimal dual targeting designs, thus broadening the therapeutic landscape and potential efficacy of cellular therapies for multiple myeloma.

PI_NAMEs: PERNA, FABIANA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Acceleration;Accounting;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;analytical tool;Antibodies;Antigen Presentation;Antigen Targeting;Antigens;Area;Autopsy;B-Lymphocytes;bi-specific T cell engager;Biology;Bone Marrow;cancer cell;CAR T cell therapy;CCR1 gene;Cell Line;Cell Maturation;Cell surface;Cell Surface Proteins;Cell Therapy;cell type;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical application;Clinical Data;cohort;combinatorial;comparative efficacy;Data;density;design;Development;Diagnosis;Disease;Disease remission;effective therapy;efficacy evaluation;Engineering;FDA approved;Flow Cytometry;Hematologic Neoplasms;Hematopoietic stem cells;high risk;IL12RB1 gene;Immunotherapeutic agent;Immunotherapy;In Vitro;in vivo;innovation;Investigation;Knowledge;Lead;Malignant - descriptor;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Medicine;Molecular Abnormality;Monoclonal Antibodies;Multiple Myeloma;new therapeutic target;Normal Cell;Normal tissue morphology;novel;novel therapeutic intervention;Operative Surgical Procedures;patient population;Patients;Pattern;Phase I Clinical Trials;Plasma Cells;Positioning Attribute;prevent;protein expression;Proteome;rational design;Recurrent disease;Refractory;Relapse;Remission Induction;Reporting;Research;Resistance;response;Role;Salvage Therapy;Sampling;single-cell RNA sequencing;Specimen;standard care;Surface;T-Lymphocyte;Technology;Therapeutic;Therapeutic Intervention;therapy resistant;Tissue Microarray;Tissues;Toxic effect;transcriptome sequencing;tumor;Tumor Antigens;Work

PROJECT_TITLE: Identifying cell surface targets for innovative immunotherapy of Multiple Myeloma

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prevention;Skin Cancer

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Recent breakthrough cancer therapies share one problem: the cancer evolving around the therapies. We have identified two key ways melanomas evolve and adapt early on therapy and will develop combination therapies to restrict this evolutionary bottleneck, preventing clinical relapses.

PI_NAMEs: LO, ROGER S (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Address;Biogenesis;Bulla;cancer therapy;Cancer Therapy Evaluation Program;Catalytic Domain;Cells;Chemicals;chromosome missegregation;chromothripsis;Clinical;clinical translation;Clinical Trials;Clonal Evolution;Code;combinatorial;Combined Modality Therapy;Complex;coping;Cutaneous Melanoma;Cytotoxic T-Lymphocytes;daughter cell;design;Development;Disease Progression;DNA;DNA Damage;DNA Double Strand Break;DNA Sequence Rearrangement;DNA-dependent protein kinase;Docking;Event;extrachromosomal DNA;fitness;gain of function;Genes;Genomic Instability;Genomic Segment;Glues;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunocompetent;immunogenic cell death;improved;in vivo;inhibitor;inhibitor therapy;insight;Letters;loss of function;Malignant Neoplasms;MEKs;Melanoma;Melanoma Cell;Melanoma patient;micronucleus;Mitogen-Activated Protein Kinase Inhibitor;Mitotic;Modeling;Molecular;Mus;neoplastic cell;Nonhomologous DNA End Joining;Nuclear;Nuclear Envelope;Pathway interactions;patient derived xenograft model;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;pressure;prevent;Preventive;Probability;Process;programmed cell death ligand 1;Proteins;Publications;Publishing;Regimen;Relapse;repaired;Residual Neoplasm;Resistance;resistance mechanism;response;Rupture;Source;Specificity;Stress;Surface;targeted treatment;Testing;Therapeutic;tool;transcriptomics;Translating;treatment response;tumor;tumor heterogeneity;Tumor Immunity;tumor-immune system interactions;Ubiquitin;ubiquitin-protein ligase;Ubiquitination;unpublished works;Untranslated RNA;Up-Regulation;whole genome;Work

PROJECT_TITLE: Preventing MAPK inhibitor resistance in melanoma by targeting genomic instability and immune resistance

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


NIH_SPENDING_CATS: Aging;Clinical Research;Genetics;Lung;Pulmonary Fibrosis;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project narrative Telomere dysfunction is the most common identifiable cause of idiopathic pulmonary fibrosis (IPF). The connection with telomeres biology provides an opportunity to see IPF in a new way. This application seeks to develop novel techniques and test hypotheses that connect telomere dysfunction and lung disease with an aim of improving the lives of patients with telomere-mediated disease.

PI_NAMEs: ALDER, JONATHAN K. (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;Affect;Age;Aging;alveolar epithelium;Alveolus;Apoptosis;Biology;Bleomycin;Cell Aging;Cells;Chromosomes;Chronic;Clinical;Communities;Data;Defect;Development;Disease;DNA Damage;DNA Sequence;Elderly;Environmental Exposure;Epithelial Cells;epithelial repair;Epithelium;Failure;Fibroblasts;Fibrosis;Functional disorder;Genes;Genetic Predisposition to Disease;genetic variant;Histologic;Human;idiopathic pulmonary fibrosis;Image;imaging modality;improved;In Vitro;Individual;Inflammation;Inflammatory;Injury;interstitial;Interstitial Lung Diseases;Lateral;Length;life span;Link;Lung;Lung Capacity;Lung Diseases;lung repair;Maps;Measures;Mediating;Methodology;Modeling;Molecular;molecular phenotype;Mus;Mutation;novel;novel strategies;novel therapeutic intervention;old mice;Onset of illness;Organ;Organoids;Other Genetics;Pathogenesis;Pathogenicity;Pathologic;Patients;Peripheral;Persons;Physiology;Predisposition;prevent;Process;progenitor;Proteins;Pulmonary Fibrosis;Regenerative capacity;repaired;Reporting;Resources;response;response to injury;Risk Factors;Role;senescence;Somatic Mutation;Spatial Distribution;stem;stem cell function;stem cells;surfactant deficiency;Techniques;Telomerase;telomere;Telomere Maintenance;Telomere Maintenance Gene;Telomere Shortening;Testing;tool;Variant;Work

PROJECT_TITLE: Mechanisms of Telomere-Mediated Lung Disease

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Microbiome

ORG_CITY: SAN FRANCISCO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative It is not understood how the yeast Candida albicans colonizes the digestive tract of most humans without causing symptoms or why it sometimes transforms into a life-threatening, invasive pathogen. By studying which fungal genes are turned on during colonization of a mouse digestive tract, we We propose to uncover the molecular activities of these and other effector proteins to learn how to maintain the fungus in a quiet state and thereby prevent dangerous infections.

PI_NAMEs: NOBLE, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Address;Affect;Animals;anti-fungal agents;Aspartic Endopeptidases;Atlases;Bar Codes;Binding;Biological Assay;Caco-2 Cells;Candida albicans;cell type;Cell Wall;Cells;Chimeric Proteins;Chitinase;Communicable Diseases;Complex;Coupling;Dangerousness;Data;Data Set;deep sequencing;Diagnosis;DNA Binding;Environment;Eukaryota;Exhibits;fitness;fitness test;Fostering;Fungal Genes;fungus;Gastrointestinal tract structure;Genes;Genetic;Genetic Transcription;Genomics;Gnotobiotic;Goblet Cells;Growth;gut colonization;gut microbiota;Hand;host colonization;Human;Immune response;in vivo;Individual;Infection;Integrin Binding;Integrins;Intestines;Knowledge;Label;Laboratories;Lead;Learning;Libraries;Life;Mass Spectrum Analysis;Mediator;meetings;Modeling;Molecular;mouse model;Mus;mutant;Mycoses;Paneth Cells;pathobiont;pathogen;Pathogenesis;Phenotype;predictive tools;prevent;Proteins;receptor;Regulation;Research;response;RGD (sequence);Signal Transduction;single-cell RNA sequencing;Site;Symbiosis;Symptoms;Testing;tool;transcription factor;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Transposase;Work;Yeasts

PROJECT_TITLE: Molecular mechanisms of Candida albicans gut colonization

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDA-D (02)]


ADMINISTERING_IC: OH

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: PISCATAWAY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: This project will complete the development of a novel Personal Electrostatic Bioaerosol Sampler (PEBS) to estimate personal exposures to biological aerosols, especially to their low concentrations. First, the developed sampler will be tested in the laboratory and in the field against other personal samplers, and then it will be used to determine personal exposures to bioaerosols in occupational environments. PEBS will be a novel standalone personal sampler capable of operating in various occupational environments to determine workers’ personal exposures to bioaerosols.

PI_NAMEs: HAN, TAEWON T;MAINELIS, GEDIMINAS  (contact)

PROGRAM_OFFICER_NAME: GARRETT, BRIDGETTE E

PROJECT_TITLE: Advanced Personal Sampler to Assess Occupational Exposures to Bioaerosols

STUDY_SECTION: SOH

STUDY_SECTION_NAME: Safety and Occupational Health Study Section[SOH]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Biomedical Imaging;Clinical Research;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Reconstruction of the medial patellofemoral ligament is the most common surgical procedure performed to treat a dislocated kneecap, but little information is available on the influence of the procedure on cartilage. The study will identify features of medial patellofemoral ligament reconstruction that adversely influence cartilage and could lead to osteoarthritis of the knee.

PI_NAMEs: ELIAS, JOHN J (contact);LI, XIAOJUAN

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Acceleration;Age Years;Algorithms;Anatomy;bone;Cartilage;cartilage degradation;Characteristics;Clinical Research;Clinical Trials;Comparative Study;cone-beam computed tomography;Control Groups;Data;Databases;design;Dislocations;Evaluation;evidence base;experience;Experimental Designs;Future;Goals;high risk;improved;Incidence;joint destruction;Knee;Knee bone;Knee Osteoarthritis;Lateral;Ligaments;Magnetic Resonance Imaging;Maps;Measurement;Measures;Medial;Minor;Morbidity - disease rate;Morphology;MRI Scans;Muscle;Operative Surgical Procedures;Outcome;Outcome Measure;Pain;Patellar Dislocation;Pathologic;Patient Outcomes Assessments;Patient Selection;Patient-Focused Outcomes;Patients;Perception;Persons;Postoperative Period;preservation;Preservation Technique;prevent;Procedures;Property;Recommendation;reconstruction;recruit;Relaxation;repaired;Risk;Selection Criteria;Time;Traumatic Arthropathy;Traumatic injury;treatment strategy;trend;Weight-Bearing state

PROJECT_TITLE: Evaluating Over Constraint of the Patella following MPFL Reconstruction as a Contributing Factor to Progressive Cartilage Degradation

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_DEPT: GENETICS

PHR: Project Narrative  Diverse factors contribute to neurodegenerative disease, but many of these converge on SARM1, an enzyme that regulates the maintenance of axons, the nerve cell appendages used to communicate to other cells. The regulation of SARM1 activity is complex and can be affected by DNA damage, which is associated with many neurological disorders as well as chemotherapy. Here we investigate SARM1 regulation and the development of a neurolytic non-opioid treatment for pain based on targeted SARM1 activation.

PI_NAMEs: DIANTONIO, AARON ;MILBRANDT, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylation;Acute;Affect;Agonist;Allosteric Regulation;analog;Apoptosis;appendage;Award;Axon;axon injury;axonal degeneration;Axotomy;Binding;Biological Markers;candidate identification;Cell Death;Cells;Cellular Stress;chemotherapy;Chronic;Chronic Disease;chronic pain;chronic pain management;clinical development;Communication;Complex;CRISPR screen;Cyclic ADP-Ribose;Data;Development;Diabetic Neuropathies;Disease;Dissection;DNA Damage;DNA Repair;Drug Kinetics;druggable target;Enzymes;Event;experimental study;Funding;Genes;Grant;Guide RNA;Human;Hydrolase;Image;Immune;Impairment;improved;in vivo;inhibitor;Injury;innovation;insight;Investigation;kinase inhibitor;Libraries;Link;Maintenance;Measures;Mediating;Medicine;member;Metabolic;Mitochondria;Mitochondrial DNA;Modeling;Molecular;Monitor;Motor Neurons;Mus;mutant;Nervous System Disorder;Neurodegenerative Disorders;Neuroma;Neurons;neuropathology;non-opioid analgesic;novel;Nuclear;Pain;Pain management;pain model;Parkin;Parkinson Disease;Pathway interactions;Peripheral Nervous System Diseases;Pharmacologic Substance;Phosphorylation;Phosphotransferases;Post-Translational Protein Processing;Post-Translational Regulation;Predisposition;Process;programs;Progressive Disease;Proteins;pyridine;rare genetic disorder;Regulation;resilience;response;screening;sensor;side effect;specific biomarkers;Technology;Testing;Therapeutic;therapeutic candidate;therapeutic development;therapeutic target;Tissues;Titrations;tool;Topoisomerase;Ubiquitination;Wallerian Degeneration;Work

PROJECT_TITLE: Dissection of SARM1-Induced Axon Degeneration and Cell Death

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cardiovascular;Genetics;Heart Disease;Women's Health Research

PHR: Project Narrative Cardiovascular (CV) toxicity associated with cancer drug treatments leads to many CV events, including hypertension, thrombosis, and cardiomyopathy. This proposal aims to explore the role and mechanisms by which endothelial cell transcription factor EB (TFEB) inhibits endothelial cell damage and cardiac dysfunction induced by cancer treatments. Our study will shed light on the vascular effects of TFEB, which would serve as the foundation for the future therapeutic strategy for cancer drug-induced CV toxicity.

PI_NAMEs: DU, WA ;FAN, YANBO  (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Adaptor Signaling Protein;Antineoplastic Agents;Apoptosis;Atherosclerosis;Autophagocytosis;Binding;Biogenesis;Blood flow;Blood Vessels;Breast Cancer Model;Breast Cancer therapy;Breast Cancer Treatment;Cancer Etiology;cancer therapy;carcinogenesis;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiotoxicity;Cardiovascular Diseases;Cardiovascular Physiology;Cardiovascular system;cell injury;Cell Physiology;Cells;chemotherapy;Clathrin;Communication;Coronary Arteriosclerosis;cytokine;Data;Development;Disabled Homolog 2 Protein;disorder risk;Doxorubicin;Endothelial Cells;Endothelium;Event;extracellular vesicles;Foundations;Functional disorder;Future;glucose tolerance;glucose uptake;heart function;Hemostatic function;Homeostasis;Human;Hypertension;Impairment;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;ischemic injury;Knockout Mice;Lysosomes;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;mouse model;Mus;Myocardial dysfunction;overexpression;Oxidative Stress;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Population;preservation;protective effect;Proteins;Recovery;Role;single-cell RNA sequencing;Solid;Testing;Therapeutic;therapeutic target;Thrombosis;Tissues;Toxic effect;transcription factor;transcriptome sequencing;Transgenes;Transgenic Mice;Transgenic Organisms;Trastuzumab;tumor;Variant

PROJECT_TITLE: Alleviation of chemotherapy-induced cardiovascular toxicity

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: 8. Project Narrative Injury to transplanted organs around the time of the surgical transplant procedure increases the risk that the recipient's immune system will attempt to reject the graft and this increases the rate at which grafts fail over many years. We hypothesize that if we treat the graft before transplantation surgery with drugs delivered directly to the lining of the graft blood vessels—particularly drugs that reduce specific changes induced by injury that increase the host immune response—we can break the link between early injury and rejection/graft loss. Specifically, we propose to do this by means of nanoparticle drug carriers that have been modified to bind to the cells that line the blood vessels and are introduced while a human kidney or heart (experimentally using organs declined for transplantation) is attached to a pump that circulates washed red blood cells, a therapy already being tested in clinical transplantation, and load these nanoparticles to deliver forms of RNA therapeutics that temporarily or permanently reduce the level of certain injury-induced proteins that have been shown to boost immune responses.

PI_NAMEs: POBER, JORDAN S (contact);SALTZMAN, W. MARK

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acute;Adaptive Immune System;Alloantigen;Allogenic;Allografting;Amines;Antibodies;antibody conjugate;Arteries;Binding;Biological Models;Blood Vessels;CD28 gene;Cell Line;Cell surface;Cells;Chronic;Clinical;Clinical Trials;Complement;Complement Activation;Complement Membrane Attack Complex;Complex;Coronary artery;Coupling;Cultured Cells;cytokine;Cytolysis;Data;Deposition;Development;donor-specific antibody;Drug Carriers;Drug Delivery Systems;efficacy evaluation;efficacy testing;Endothelial Cells;Endothelium;Enzymes;epigenetic silencing;Erythrocytes;Esters;experimental study;Fibrinogen;Formulation;Frequencies;Genes;Graft Survival;Heart;heart allograft;Heterotopic Transplantation;Human;ICOS protein;Immune response;Immune system;Immunodeficient Mouse;immunogenicity;Immunoglobulin G;Immunoglobulin M;Immunosuppression;implantation;improved;In Vitro;in vivo;Inflammation;Injury;Interleukin-1;Interleukin-15;Interleukin-2;Kidney;kidney allograft;knock-down;Link;Liquid substance;Liver;Mediating;Mediator;Membrane Proteins;Messenger RNA;Methods;migration;Modeling;Molecular Target;mouse model;mRNA delivery;Mus;nanoparticle;nanoparticle delivery;nanoparticle drug;nanopolymer;new technology;Organ;Organ Culture Techniques;Organ Donor;Organ Transplantation;particle;Patients;Perfusion;Perioperative;Phagocytes;Pharmaceutical Preparations;Polyamines;Polymers;Postoperative Period;pre-clinical;prevent;Procedures;protein expression;Proteins;Pump;Reagent;recruit;Regional Perfusion;Reperfusion Injury;response;Risk;RNA delivery;Rodent;Severities;Signal Transduction;siRNA delivery;Small Interfering RNA;Solid;Spleen;Surface;T cell response;T cell therapy;T memory cell;T-Lymphocyte;targeted delivery;Technology;Testing;therapeutic nanoparticles;therapeutic RNA;therapeutic siRNA;Time;transplant model;Transplantation;Transplantation Surgery

PROJECT_TITLE: Ex Vivo Nanoparticle Drug Delivery Targeted to Human Allograft Endothelium

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Dietary Supplements;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_DEPT: PSYCHIATRY

PHR: Correcting age-related reductions in brain docosahexaenoic acid (DHA) levels represents a plausible strategy to mitigate progressive neurodegenerative processes associated with dementia. Although recent evidence indicates that DHA in the form of lysophosphatidylcholine-DHA (LPC-DHA) is significantly more effective for increasing brain DHA levels than is the commonly used triglyceride-DHA (TAG-DHA), the effects of LPC-DHA supplementation on human CNS DHA delivery have not been investigated. We propose to conduct the first proof-of-concept randomized, double-blind, placebo-controlled trial to compare the effects of LPC-DHA and TAG-DHA supplementation on cerebrospinal fluid DHA levels and neurodegeneration biomarkers in aging adults at risk for dementia.

PI_NAMEs: KRIKORIAN, ROBERT ;MCNAMARA, ROBERT K. (contact)

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: abeta deposition;Acids;Address;Adult;Age;age related;age related decline;aged;Aging;Alleles;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid beta-42;Amyloid deposition;Anabolism;Attenuated;Autopsy;Biological Availability;Biological Markers;biosynthetic product;Blood;Blood - brain barrier anatomy;Brain;Brain region;Brain-Derived Neurotrophic Factor;capsule;Cerebral Ischemia;Cerebrospinal Fluid;Clinical Research;Clinical Trials;Cognitive;cognitive function;cognitive testing;Consumption;cost effective;Dementia;dementia risk;dietary;Disease Progression;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;double-blind placebo controlled trial;Early Intervention;Elderly;Episodic memory;Esterification;executive function;Exhibits;Fish Oils;Fishes;Foundations;Future;genetic variant;hippocampal cell loss;Human;human subject;Impaired cognition;Impairment;improved;Intervention;Knowledge;Learning;Lecithin;longitudinal, prospective study;Lysophosphatidylcholines;Measures;Memory;mouse model;Mutant Strains Mice;Nerve Degeneration;neuroimaging;neuroprotection;novel;Oils;Omega-3 Fatty Acids;Outcome;Patient Self-Report;Performance;Peripheral;peripheral blood;Phase;placebo controlled trial;Placebos;Plasma;pre-clinical;premature;Process;prophylactic;prospective;Randomized;Research;Risk;Risk Reduction;Rodent;Sampling;Signal Transduction;Source;Supplementation;Testing;Translating;trial design;Triglycerides;uptake;Wild Type Mouse

PROJECT_TITLE: Optimizing CNS DHA delivery in elderly adults at risk for dementia

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Narrative  Consumption of a diet high in fat and fructose is associated with a range of metabolic consequences that can lead to obesity, glucose intolerance, and diabetes, a public health crisis characterized by disability, loss of life, and great financial expense. The research described in this application seeks to understand the fundamental ways that such a diet changes the regulation of glucose metabolism, as well as the efficacy of potential treatment strategies. Our canine model is ideally positioned to act as a bridge between in vitro / small animal research and the human, allowing us to facilitate the translation of promising discoveries as well as the ability to test control mechanisms using strategies that are not possible in other species.

PI_NAMEs: CHERRINGTON, ALAN D;EDGERTON, DALE S (contact)

PROGRAM_OFFICER_NAME: LIANG, HANYU

PROJECT_TERMS: absorption;Acute;Affect;Amino Acids;analog;Animal Experimentation;Animal Feed;Animals;Arteries;basal insulin;Blood;Blood flow;blood glucose regulation;canine model;Canis familiaris;cardiovascular risk factor;Clinical;Compensation;Complex;Consumption;Data;Defect;design;Development;Diabetes Mellitus;Diet;disability;effective therapy;Effectiveness;effectiveness evaluation;efficacy evaluation;Endocrine;experimental study;falls;Fasting;Fatty acid glycerol esters;feeding;Formulation;Fructose;Functional disorder;gain of function;Glucagon;Gluconeogenesis;Glucose;glucose disposal;Glucose Intolerance;glucose metabolism;glucose production;glucose tolerance;glucose uptake;glycogenolysis;Hepatic;Homeostasis;Hormones;Human;Hyperglycemia;Hyperinsulinism;Hypoglycemia;Impairment;In Vitro;Individual;Infusion procedures;Ingestion;Injections;Insulin;Insulin deficiency;Insulin Resistance;Intravenous;Knowledge;Life;Liver;Liver Dysfunction;Maintenance;Measurement;Measures;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolism;Molecular;Muscle;Nervous System;neural;Non-Insulin-Dependent Diabetes Mellitus;novel therapeutic intervention;Nutrient;Obesity;obesogenic;OGTT;pancreatic juice;Patients;Peripheral;Physiological;Play;Portal vein structure;Positioning Attribute;prevent;Process;protein metabolism;Proteins;Public Health;Recycling;Regulation;Research;Resistance;response;Risk Factors;Rodent;Role;Route;Sampling;sensor;Signal Transduction;Source;subcutaneous;synergism;Testing;tool;Translations;treatment strategy;uptake;western diet;Work

PROJECT_TITLE: Gluconeogenesis and Glycogenolysis - Role and Regulation

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Arthritis;Osteoarthritis

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Our overarching goal is to develop optical redox imaging (ORI)-based medical instruments to guide surgical and therapeutic approaches. This project will (1) develop a stress test to diagnose cartilage disease based on changes in ORI metrics and material behavior; (2) develop an ex vivo system to test emergent therapeutic strategies following impact injury; and (3) develop and validate a medical instrument that captures ORI for staging in vivo cartilage disease.

PI_NAMEs: HENAK, CORINNE R (contact)

PROJECT_TERMS: Anatomy;Antioxidants;Arthroscopes;Arthroscopic Surgical Procedures;Arthroscopy;Behavior;Biochemical;cancer therapy;cardiovascular health;Cartilage;Cartilage Diseases;Cartilage injury;Cells;Classification;Clinical;clinical translation;Coupled;Coupling;Data;Degenerative polyarthritis;Devices;Diagnosis;Diagnostic;Diagnostic Procedure;diagnostic tool;Disease;effective intervention;electron donor;Equilibrium;Evaluation;Future;Goals;Health;Histopathology;Human;Image;imaging system;improved;in vivo;Injury;insight;instrument;Intervention;joint injury;Joints;Knee;Label;Lesion;Malignant Neoplasms;Measures;mechanical stimulus;Mechanical Stress;Mechanics;Medical;Metabolic;Methods;Microscope;mitochondrial dysfunction;Modeling;Molecular;NADH;NADP;Non-Steroidal Anti-Inflammatory Agents;Operative Surgical Procedures;Optics;Organoids;Oxidants;Oxidation-Reduction;Oxygen;Pathologic;Pathology;Patients;pharmacologic;Procedures;Process;programs;Rapid screening;Relaxation;Research;Research Project Grants;response;Screening for cancer;Screening procedure;Serum;Staging;Stress;Stress Tests;Subgroup;success;System;Testing;Thallium Myocardial Perfusion Imaging Stress Test;Therapeutic;therapeutic evaluation;Time;Tissues;tool;Translations;Traumatic injury;treatment response;Variant

PROJECT_TITLE: Using redox balance to guide surgical and therapeutic decisions for cartilage disease

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Youth-onset type 2 diabetes is rapidly increasing in incidence, carries a high risk of severe complications in early adulthood, and disproportionately impacts marginalized communities. Adolescents and young adults with type 2 diabetes often face barriers to healthy lifestyle change and diabetes self-management, including limited or delayed feedback on how such health behavior changes affect blood sugar. Our study, REFLECT2D, will evaluate use a novel smartphone app pairing real-time health behavior and glycemic data, laying the foundation for future interventions that use the right type of data at the right time to support health behavior change, ultimately improving outcomes for adolescents and young adults with type 2 diabetes.

PI_NAMEs: VAJRAVELU, MARY ELLEN (contact)

PROGRAM_OFFICER_NAME: CENTER, MAUREEN MONAGHAN

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Adherence;Adolescent and Young Adult;Adult;Affect;Age;behavior change;behavior measurement;Behavior Therapy;Behavioral;Blood Glucose;Body mass index;Caring;Certification;Childhood;Clinical Trials;Continuous Glucose Monitor;Data;design;Development;diabetes education;diabetes educator;Diabetes Mellitus;diabetes self-management;Diagnosis;Diet;Dietary intake;Dietitian;digital;Distal;Education;emerging adult;Enrollment;ethnic minority;Exercise;Face;Feedback;Fingers;fitbit;follow-up;Fostering;Foundations;Future;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;Growth;Health behavior;Health behavior change;health disparity;health equity;health outcome disparity;Healthy Eating;healthy lifestyle;high risk;Hour;Hyperglycemia;improved;improved outcome;Incidence;Individual;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;learning engagement;Life Expectancy;Maintenance;marginalized community;Measures;Mediating;Mediator;minority children;mobile application;Modeling;Modification;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;nutrition;older adult;Outcome;Participant;Persons;Physical activity;poor health outcome;Poverty;Prediabetes syndrome;Probability;racial minority;Randomized;randomized trial;Role;Running;Self Efficacy;skills;smartphone application;Specialist;Time;trend;Visit;Visual;wearable device;Work;Youth

PROJECT_TITLE: REFLECT2D: Real-time Engagement For Learning to Effectively Control Type 2 Diabetes

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Biodefense and Related Countermeasures;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Disability Research;Emerging Infectious Diseases;Infectious Diseases;Physical Activity;Physical Rehabilitation;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rehabilitation

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA OMAHA

ORG_STATE: NE

PHR: Post-acute sequelae of SARS-CoV-2 infection (PASC) is becoming a major risk factor for chronic diseases, with older adults and those with underlying health conditions at risk of developing persistent mobility limitations and disabilities. Although exercise intervention is a common strategy to restore functional capacity, it may not be feasible or enticing to many people with PASC. This clinical trial seeks to establish the tolerability and efficacy of at home lower-body heat therapy for improving functional capacity along with metabolic and vascular health in late-middle aged and older adults with PASC, also known as “long COVID”.

PI_NAMEs: LAYEC, GWENAEL  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: 2019-nCoV;Activities of Daily Living;acute care;Adherence;Adult;Adverse event;Affect;arterial stiffness;Attenuated;Behavior;blood glucose regulation;Blood specimen;Blood Vessels;burden of illness;cardiovascular disorder risk;Chronic Disease;Clinical;Clinical Trials;cognitive function;common symptom;comorbidity;comparison control;Complex;Complication;COVID-19;Data;design;disability;Doppler Ultrasound;Effectiveness;endothelial dysfunction;Exercise;exercise intervention;exercise training;Exertion;Exhibits;experience;Fasting;Femur;Frequencies;Functional disorder;functional restoration;Future;Gait speed;Goals;group intervention;Health;Health Benefit;Home;Hospitalization;Impaired cognition;impaired functional status;improved;in vitro Assay;in vivo magnetic resonance spectroscopy;Incidence;Individual;Inferior;Inflammation;Intervention;Long COVID;Long term disability;Magnetic Resonance Spectroscopy;Malaise;Measures;Mediating;men;Metabolic;Metabolic Control;Metabolic Diseases;Metabolic Marker;metabolic profile;Metabolism;middle age;Mitochondria;Mobility decline;Muscle;Nonpharmacologic Therapy;older adult;Outcome;Oxidation-Reduction;Oxidative Stress;Participant;participant enrollment;Patients;Peripheral;Persons;Physical activity;Physical Function;Physical Performance;Physical Rehabilitation;Physiologic pulse;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;programs;Public Health;Random Allocation;Randomized;Recovery of Function;rehabilitation paradigm;rehabilitation strategy;Rehabilitation therapy;Reporting;Research;Risk;Risk Factors;Safety;SARS-CoV-2 infection;Skin Temperature;Surrogate Markers;Symptoms;Techniques;Testing;Therapeutic heat application;three-arm study;Vascular Diseases;Vascular Endothelium;Walking;walking intervention;wearable device;Woman;Work

PROJECT_TITLE: Heat Therapy for the treatment of post-acute COVID-19 syndrome

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Depression;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Major Depressive Disorder;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Serious Mental Illness

PHR: NARRATIVE Major depression and anxiety are very important causes of morbidity and mortality on the population level. Methods in genetics such as genomewide association studies (GWAS) that have been used to untangle and understand the biology of other complex genetic traits have only recently been brought to bear on these traits. Using the most extensive and informative databases available worldwide, we will use large-scale GWAS to increase understanding of the genetics and biology of these important mental illnesses, in European, African, and Latinx populations, work that will facilitate bringing novel therapeutics and personalized medicine approaches to the treatment of these illnesses.

PI_NAMEs: GELERNTER, JOEL  (contact);STEIN, MURRAY B.

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Address;African;African American population;Alcohol consumption;American;Anti-Anxiety Agents;anti-depressive agents;Anxiety;Anxiety Disorders;anxiety-related disorders;Architecture;Back;biobank;Biological;Biology;Cardiovascular Diseases;Clinic;Clinical;Cognition;cohort;Collaborations;Complex Genetic Trait;Copy Number Polymorphism;Data;Data Reporting;Data Set;database of Genotypes and Phenotypes;Databases;density;Depressive disorder;Diagnosis;disorder risk;drug repurposing;Drug usage;Electronic Health Record;Equation;Etiology;European;experience;Female;follow-up;gene discovery;Genetic;genetic architecture;Genetic Risk;Genetic study;Genetic Variation;genome wide association study;Genomics;Health behavior;Heart Diseases;Human;improved;Individual;insight;interest;Joints;Latinx;Latinx population;Link;Major Depressive Disorder;male;Malignant Neoplasms;Maps;Measures;Medical;Mendelian randomization;Mental Depression;Mental disorders;Mental Health;Meta-Analysis;Methods;Modeling;Morbidity - disease rate;mortality;novel;novel therapeutics;Outcome;Participant;Pathogenesis;Patient Self-Report;personalized medicine;Pharmaceutical Preparations;phenome;Phenotype;phenotypic data;Physical activity;pleiotropism;polygenic risk score;Polygenic Traits;Population;Population Genetics;Positioning Attribute;Post-Traumatic Stress Disorders;Predisposition;programs;psychiatric genomics;Psychopathology;Questionnaires;rare variant;recruit;Resources;response;risk variant;Sampling;Selective Serotonin Reuptake Inhibitor;sex;Social Phobia;Symptoms;Testing;trait;United States Department of Veterans Affairs;Variant;Veterans;whole genome;Work;working group

PROJECT_TITLE: Expanding Genetic Understanding of Depression, Anxiety, and their Treatments

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Eye Disease and Disorders of Vision;Genetic Testing;Genetics;Human Genome;Neurodegenerative;Rare Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS EYE AND EAR INFIRMARY

PHR: Project Narrative Inherited retinal degenerations (IRDs) are a genetically heterogeneous group of disorders that are important causes of vision loss. The goals of the proposed research are to improve our ability to identify the genetic cause of IRDs by investigating variants that potentially lead to aberrant pre-mRNA splicing and structural genomic rearrangements that can lead to disease. Results of the proposed studies will lead to new genetic diagnoses, which will enhance patients’ clinical care and will provide them with opportunities to participate in clinical trials and receive approved genetic treatments.

PI_NAMEs: BUJAKOWSKA, KINGA  (contact)

PROGRAM_OFFICER_NAME: GAO, JAMES

PROJECT_TERMS: Address;Affect;Algorithms;Alleles;Alternative Splicing;autosome;Base Pairing;Biological Assay;Biology;Blindness;Cardiology;cell type;clinical care;Clinical Trials;clinically actionable;clinically relevant;ClinVar;Code;cohort;Complex;Copy Number Polymorphism;Data;Defect;Detection;Diagnostic;Diagnostic tests;Disease;DNA Sequence Rearrangement;Etiology;exon skipping;Exons;falls;Family;Family Planning;Gene Expression;gene function;Genes;Genetic;genetic disorder diagnosis;genetic testing;genome sequencing;Genomic medicine;genomic variation;Goals;Human Genetics;improved;inherited retinal degeneration;insertion/deletion mutation;machine learning algorithm;Malignant Neoplasms;Medical Genetics;Mendelian disorder;MERTK gene;Modeling;mRNA Precursor;Mutation;novel;Pathogenicity;Patients;Phenotype;Preventive measure;Prognosis;prognostic;Rare Diseases;rare variant;Reporting;Reproducibility;Research;RNA Splicing;RPE65 protein;RPGR gene;Single Nucleotide Polymorphism;Site;software development;Surveys;targeted sequencing;Testing;Untranslated RNA;USH2A gene;Variant;variant of unknown significance

PROJECT_TITLE: Finding Missing Genetic Causality of Inherited Retinal Degenerations

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: American Indian or Alaska Native;Diabetes;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Liver Disease;Nutrition;Obesity;Racial and Ethnic Minority Health Research

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE 4-hydroxy fatty acids comprise a lipid class of emerging importance to mammalian physiology, yet their metabolism is poorly understood. Our work aims to establish the primary enzymes responsible for initiating the breakdown of these lipids and the metabolic ramifications that result from the disruption of these enzymes in cells, worms, mice, and humans. Completion of these goals will add a fundamental new aspect to our understanding of lipid metabolism, link 4-hydroxy fatty acids to specific physiological dysfunctions, and identify potential new therapeutic targets for the treatment of certain disorders related to fatty acid breakdown.

PI_NAMEs: PAGLIARINI, DAVID J (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acetyl Coenzyme A;Acids;Active Sites;acyl-CoA dehydrogenase;acyl-CoA oxidase;Anabolism;Biochemical;Biochemical Reaction;Biological Assay;branched chain fatty acid;Breeding;Carbon;Catabolism;Cell Line;Cells;Chronic;Chronic Kidney Failure;Citric Acid Cycle;cohort;combat;Coronary Arteriosclerosis;CRISPR/Cas technology;Cryoelectron Microscopy;Custom;Data;Deposition;Development;Diabetes Mellitus;Dietary intake;Disease;Drug Metabolic Detoxication;drug of abuse;empowerment;Engineering;Enzymatic Biochemistry;Enzymes;Family;Fatty acid glycerol esters;fatty acid metabolism;Fatty Acids;fatty liver disease;Female;forging;Fractionation;Friends;Functional disorder;Genetic;Genetic Polymorphism;genome wide association study;Goals;Health;Hepatocyte;Human;Hydroxy Acids;hydroxy fatty acid;hydroxyl group;Hydroxylation;Hypoglycemia;In Vitro;Insulin Resistance;Investigation;Kidney Diseases;kidney dysfunction;Knockout Mice;Length;Link;lipid metabolism;Lipid Peroxidation;lipidomics;Lipids;Liver;Liver Dysfunction;Location;Mass Spectrum Analysis;member;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Metabolic syndrome;Metabolism;Methods;Microscopy;Mitochondria;Modernization;Monitor;mouse model;Mus;Mutation;N Domain;N-terminal;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organelles;oxidation;Oxidoreductase;Pathway interactions;peroxisome;Phosphorylation;Phosphotransferases;Physiological;Physiology;pi bond;Pima Indian;Plasma;Positioning Attribute;Process;Production;Reaction;Recombinants;Rhabdomyolysis;Role;Series;Signaling Molecule;structural biology;Structure;Testing;Therapeutic;Tribes;Variant;Weight Gain;Work

PROJECT_TITLE: Defining the roles of ACAD10/11 in hydroxy lipid catabolism and metabolic disease

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


ED_INST_TYPE: OVERALL MEDICAL

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Autoimmune Disease;Chronic Pain;Diabetes;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: HOUSTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative: This project aims to fundamentally change how we view the role of tau in the peripheral nervous system. It will first solidify the role of tau phosphorylation in diabetic peripheral neuropathy, and then determine the dependence of tau phosphorylation on insulin signaling and GSK3β within peripheral nerves. Thus, through these innovative experiments, we will deepen our understanding of the peripheral nervous system and provide new therapeutic targets for peripheral neuropathy in diabetic patients.

PI_NAMEs: NICHOLS, JAMES M (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Ablation;adeno-associated viral vector;Affect;Afferent Neurons;Anticonvulsants;Attenuated;Award;behavior test;Biological Models;Cancer Center;career;career development;cell type;Cells;Clinical;Collaborations;college;Complication;Core Facility;Data;delivery vehicle;Dependence;Development;Diabetes Mellitus;diabetic;Diabetic mouse;Diabetic Neuropathies;diabetic patient;Distal;Education;Environment;experience;experimental study;Gene Deletion;Genetic;glycogen synthase kinase 3 beta;Goals;Grant;Growth;High Fat Diet;Hypersensitivity;In Vitro;in vitro Model;in vivo;in vivo Model;inhibitor;innovation;Insulin;Insulin deficiency;Insulin Receptor;insulin signaling;Insulin Signaling Pathway;Insulin-Dependent Diabetes Mellitus;Intervention;Intrathecal Injections;Laboratories;Linear Regressions;Literature;Measurable;Mechanics;Medical Students;Medicine;meetings;Mentors;Mentorship;Metabolic;Microscopy;Microtubules;Modeling;Mus;Neurites;neuroimmunology;Neurologic;Neurologic Dysfunctions;Neuronal Dysfunction;Neurons;Neuropathy;new therapeutic target;next generation;Nociceptors;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutics;Numbness;Opioid;Pain;pain relief;painful neuropathy;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Peripheral Nerves;Peripheral Nervous System;Peripheral Nervous System Diseases;Persons;Phase;Phosphorylation;Phosphorylation Inhibition;Physiology;PIK3CG gene;Plasmids;Polyneuropathy;professor;protective effect;Proteins;Proto-Oncogene Proteins c-akt;Publications;Recording of previous events;Research;Research Technics;Role;sciatic nerve;Scientist;Selective Serotonin Reuptake Inhibitor;sensory neuropathy;Signal Transduction;Site;Streptozocin;Students;Symptoms;System;tau dysfunction;tau Proteins;tau-1;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Training;Tricyclic Antidepressive Agents;TRPV1 gene;Variant;Veterinary Medicine;volunteer;Western Blotting;Work;Writing

PROJECT_TITLE: The Role of Tau Phosphorylation in Diabetic Peripheral Neuropathy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (56)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Physical Activity;Prevention

ORG_CITY: PENSACOLA

ORG_NAME: FLORIDA INSTITU /HUMAN/MACHINE COGNITION

PHR: Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercise responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult’s capacity to attain the many health benefits of exercise.

PI_NAMEs: BAMMAN, MARCAS M (contact);BODINE, SUE C;MILLER, BENJAMIN FRANCIS

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acute;Address;Adjuvant;Adult;age group;Aging;aging related;Behavior;Biogenesis;Biological;Biological Process;Blood;cardiorespiratory fitness;cellular targeting;Circadian Dysregulation;circadian pacemaker;Classification;Clinical;clinical phenotype;Collection;Communication;Continuous Glucose Monitor;Coupled;design;Deterioration;Diet;Dimensions;Dose;Educational workshop;efficacy evaluation;efficacy testing;Endogenous Factors;epigenomics;Exercise;exercise program;exercise training;Exogenous Factors;extracellular vesicles;forging;Fostering;functional decline;Goals;Guidelines;hallmarks of aging;Health Benefit;healthspan;Heterogeneity;Impairment;improved;Individual;individual response;Inflammation;Influentials;innovation;Knowledge;Life Style;Link;machine learning framework;Metabolic;Mitochondria;mode of exercise;Modeling;Molecular;Muscle;muscle form;Muscle Mitochondria;nutrition;older adult;Outcome;Output;Participant;Performance;Pharmaceutical Preparations;Phase;phase I trial;phase II trial;Phenotype;predictive modeling;proteostasis;Psyche structure;Public Health;Quality of life;Randomized;Recommendation;resistance exercise;Resources;response;Role;Sequential Multiple Assignment Randomized Trial;Series;sex;Signal Transduction;Sleep;Source;Specific qualifier value;System;Testing;Time;Tissues;Titrations;Training;transcriptomics;Variant;VO2max

PROJECT_TITLE: Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-A (M1)]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Precision Medicine;Radiation Oncology;Rare Diseases

PHR: PROJECT NARRATIVE: Novel PET Imaging to Guide Therapy in Hepatocellular Carcinoma In patients with hepatocellular carcinoma (HCC), locoregional therapies (LRTs) such as transcatheter arterial radioembolization (TARE) with Yttrium-90 (Y90) are often used as bridge therapies to prevent tumor growth and progression while awaiting a donor liver for orthotopic liver transplantation (OLT), to downstage lesions to meet eligibility for OLT, or as palliative care. Clinical decisions regarding treatment response remain largely guided by conventional imaging modalities but are ambiguous at early time points following therapy. This application proposes to explore a non-invasive PET imaging method to predict response to Y90 TARE therapy early in the course of treatment.

PI_NAMEs: MANNING, HENRY CHARLES (contact)

PROGRAM_OFFICER_NAME: TANDON, PUSHPA

PROJECT_TERMS: 90Y;Aftercare;Algorithms;anatomic imaging;Biological Markers;Blood;Body Fluids;cancer cell;Cancer Etiology;Caring;Cessation of life;Clinical;Collection;Cystine;Data;Detection;Disease;disease heterogeneity;Disease Management;Disease Resistance;Early treatment;Eligibility Determination;Evaluation;Face;Future;Glutathione;Image;imaging approach;imaging modality;improved;innovation;Intervention;Lesion;Link;liquid biopsy;Liver;liver transplantation;Localized Disease;longitudinal positron emission tomography;Magnetic Resonance Imaging;Malignant neoplasm of liver;Mediating;Methods;minimally invasive;Molecular;molecular imaging;Neoplasm Circulating Cells;novel;Operative Surgical Procedures;palliative;Palliative Care;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Physicians;Play;population based;Positron-Emission Tomography;predicting response;prevent;Primary carcinoma of the liver cells;Progression-Free Survivals;Progressive Disease;Radiation;radiation resistance;Radiation therapy;Radioembolization;Reactive Oxygen Species;Recurrence;Recurrent disease;Recurrent tumor;Regulation;Reporting;Residual Neoplasm;Residual state;Resistance;response;Role;screening;Signal Transduction;Specimen;standard of care;Testing;Time;Transplantation;Treatment outcome;treatment response;tumor;tumor DNA;tumor growth;tumor progression;Tumor stage;Tumor-Derived;Uncertainty;uptake;X-Ray Computed Tomography