NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CLEVELAND

ORG_DEPT: PHYSIOLOGY

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Ionotropic glutamate receptors (iGluRs) are key molecules that play fundamental roles in neuronal excitability/functions and memory formation in the mammalian brain. In order to better understand the molecular mechanism of the entire iGluR superfamily and how protein co-factors regulate iGluR receptor activities, we will, herein, investigate the structure and function of native kainate receptor-type iGluRs from mammalian brains. We are particularly interested in how kainate-type ionotropic glutamate receptor (KAR) ligands, brain lipids, and protein co-factors modulate the functions of the receptor. This proposed research will provide novel insights, which will be helpful for the future development of treatment strategies.

PI_NAMEs: TAJIMA, NAMI  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Alzheimer's Disease;autism spectrum disorder;Brain;Brain Diseases;Cholesterol;cofactor;Complex;Cryoelectron Microscopy;Development;Distant;Drug Targeting;Electrophysiology (science);Environment;Epilepsy;Exhibits;Functional disorder;Future;Glutamate Receptor;glutamatergic signaling;Homo;Huntington Disease;insight;interest;kainate;Kainic Acid Receptors;Learning;Ligands;Lipids;Major Depressive Disorder;Mediating;Memory;Modification;Molecular;Molecular Conformation;Mood Disorders;neural;neuronal excitability;Neurons;neuropathology;Neuropilins;neurotransmitter release;novel;novel therapeutic intervention;pharmacologic;Physiological;Play;Post-Translational Protein Processing;postsynaptic;programs;Property;Proteins;Rattus;receptor;receptor function;Regulation;Research;Resolution;Role;Schizophrenia;Signal Transduction;small molecule;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;therapy development;treatment strategy

PROJECT_TITLE: Structure and Function of native kainate-type ionotropic glutamate receptor complexes

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Eye Disease and Disorders of Vision;Genetics;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Narrative The goal of this proposal is to employ the Neurofibromatosis type 1 (NF1) childhood brain cancer predisposition syndrome as an experimental platform to mechanistically define the selective role of CD8+ T cells as central cellular integrators of neuron-mediated and immune system modulation of glioma formation and growth. OMB No. 0925-0001/0002 (Rev. 03/2020 Approved Through 02/28/2023) Page 1 Continuation Format Page

PI_NAMEs: GUTMANN, DAVID H (contact)

PROGRAM_OFFICER_NAME: JHAPPAN, CHAMELLI

PROJECT_TERMS: Adult;Affect;Antibodies;Astrocytoma;Blindness;Blood;Brain;Brain Neoplasms;cancer cell;Cancer Cell Growth;cancer predisposition;Carboplatin;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Child;Childhood;Childhood Malignant Brain Tumor;Common Neoplasm;conventional therapy;cytokine;Data;Dependence;design;Development;Etiology;Evolution;Experimental Designs;experimental study;Flow Cytometry;Future;Gene Mutation;Genetic Transcription;genotoxicity;Glioma;Goals;Growth;Growth Factor;Heterozygote;Human;Immune;immune modulating agents;Immune system;Immunohistochemistry;In Vitro;in vivo;Individual;inhibitor;Laboratories;Lymphocyte;Macrophage;Malignant - descriptor;Malignant Glioma;Malignant neoplasm of brain;Mediating;Medical;MEKs;Meninges;Microglia;midkine;Molecular;Molecular Target;monocyte;Morbidity - disease rate;mouse model;Mouse Strains;Mus;mutant;Mutant Strains Mice;Mutation;Neoplasms;Neurofibromatosis 1;neuronal excitability;Neurons;neurotoxicity;NF1 gene;NF1 mutation;Optic Nerve;Optic Nerve Glioma;Optics;Pathway interactions;Patients;pediatric low grade glioma;Persons;Population;Population Dynamics;Production;Property;recruit;Regulation;Role;Series;single-cell RNA sequencing;Solid Neoplasm;Syndrome;T cell regulation;T-Cell Activation;T-Cell Depletion;T-Lymphocyte;Testing;tumor;Tumor-Associated Process;Vincristine

PROJECT_TITLE: T Cell Regulation of Low-Grade Glioma

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Diffuse intrinsic pontine glioma is a devastating pediatric brain tumor that despite decades of clinical trials remains fatal with a median survival of less than a year. This proposal focuses on the development of safe and effective immune-based therapies for these tumors, using chimeric antigen receptor T cell therapy. Through these studies we hope to improve our understanding of the tumor growth within the immune microenvironment and translate effective immunotherapies to patients.

PI_NAMEs: FOSTER, JESSICA B (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Advisory Committees;Architecture;blood-brain barrier crossing;Brain Neoplasms;Brain Stem;Cancer Etiology;CAR T cell therapy;career;Cell surface;Cell Therapy;Cells;Child;Childhood;Childhood Brain Neoplasm;childhood cancer mortality;Childhood Glioma;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical Trials;combinatorial;comparative efficacy;CSF1R gene;cytotoxicity;Dedications;Development;Diffuse intrinsic pontine glioma;DNA;Dose;empowerment;Environment;Evaluation;experience;Faculty;FDA approved;Five-Year Plans;Flow Cytometry;Fostering;Foundations;glioma cell line;Goals;Grant;high dimensionality;Human;Human Cell Line;Immune;Immune system;Immunocompetent;Immunogenomics;Immunohistochemistry;Immunologics;immunosuppressed;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;in vivo Model;Inflammation;Inflammatory;Infusion procedures;inhibitor;International;K-Series Research Career Programs;Laboratories;Location;Malignant Childhood Neoplasm;manufacture;member;Mentors;Mentorship;Messenger RNA;Microglia;Modeling;Molecular;mouse model;Mus;neoplastic cell;nestin protein;neural;Neuroblastoma;neuroinflammation;Neurologic;Neurons;Normal tissue morphology;novel;Nucleosides;overexpression;Patients;PDGFA gene;Pediatric Hospitals;Pennsylvania;Pharmaceutical Preparations;Philadelphia;Physicians;Pontine structure;pre-clinical;preclinical evaluation;Preclinical Testing;Research;Resources;Role;Safety;safety testing;Scientist;sialogangliosides;Signal Transduction;single-cell RNA sequencing;stem cells;Swelling;T-Lymphocyte;Technical Expertise;Techniques;Technology;Testing;Therapeutic;Therapeutic Index;Tissues;Titrations;tool;Toxic effect;TP53 gene;Training;Transgenic Organisms;Translating;translational physician;translational research program;translational study;Translations;Treatment-related toxicity;tumor;tumor growth;tumor microenvironment;tumor-immune system interactions;Universities;Viral;Work;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Defining a therapeutic platform for DIPG with mRNA CAR T cells and microglia inhibition

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Adipose tissue macrophages, a specialized population of immune cells that reside in fat tissue, are known to play a significant role in the pathophysiology of obesity, a common condition that is associated with insulin resistance and inflammation, as well as significant disease burden. A recent study established that adipocyte- derived exosomes modulate adipose tissue macrophages. This project aims to further our understanding of the effects of adipocyte-derived exosomes on macrophage recruitment and differentiation, as well as determine whether this regulation is dependent upon canonical pathways involved in adipose tissue macrophage recruitment and differentiation.

PI_NAMEs: GOODMAN, JOSHUA HARRISON (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Acute;Adipocytes;Adipose tissue;Adult;Affect;Animals;Anti-Inflammatory Agents;Autoimmune Diseases;Automobile Driving;Binding;Biogenesis;Biology;Bone Marrow;burden of illness;Cardiovascular Diseases;Cells;Chemotactic Factors;Chemotaxis;Chemotaxis Induction;Dementia;Deposition;Development;Diabetes Mellitus;Disease;Embryo;Endosomes;Endothelial Cells;Etiology;exosome;extracellular vesicles;Fasting;Fatty acid glycerol esters;Fetal Liver;Functional disorder;Genetic Transcription;graduate student;Hematopoiesis;Hematopoietic stem cells;Homeostasis;Human;Hypertrophy;Immune;In Vitro;in vivo;Inflammation;Inflammatory;Infusion procedures;Injections;insight;Insulin Resistance;Laboratories;lipid metabolism;Lipids;Lipolysis;Lung Diseases;Macrophage;Malignant Neoplasms;mature animal;Mediating;Membrane;Metabolic;Metabolic stress;Molecular;Monitor;monocyte;Mus;novel therapeutic intervention;Obesity;obesity development;Organ;Pathology;Pathway interactions;Peripheral;Phenotype;Play;poor health outcome;Population;PPARG gene;precursor cell;Process;Production;progenitor;programs;recruit;Refuse Disposal;Regulation;response;Rodent;Role;Signal Transduction;Source;stem cells;Stimulus;Testing;Tissues;Work;Yolk Sac

PROJECT_TITLE: Adipocyte-derived exosomes in macrophage regulation


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Immunotherapy

ORG_CITY: PITTSBURGH

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE The immune system thrives on balance between overexuberant and insufficient immune responses. Maintaining this balance are a subpopulation of T lymphocytes termed regulatory T cells, which are essential guardians against autoimmune disease but culprits in pathologies of insufficient immunity like cancer. Regulatory T cells live within tissues and have adapted a metabolic profile to thrive therein, and despite substantial inflammation can maintain their identity. In this proposal, we will study how the metabolites present in tissues like cancer or in inflamed intestine interact with regulatory T cells and promote their function.

PI_NAMEs: DELGOFFE, GREG M. (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acetylation;Affect;alpha ketoglutarate;Autoimmune;Autoimmune Diseases;Autoimmunity;Bacteria;Binding;cancer cell;CD4 Positive T Lymphocytes;Cell Physiology;Cells;Cellular biology;Chemosensitization;Coupling;CTLA4 blockade;Cues;Data;demethylation;design;Disease;dysbiosis;effector T cell;Enteral;Environment;Epigenetic Process;epigenome;Equilibrium;Event;Exposure to;FOXP3 gene;Functional disorder;Genes;Genetic;Glucose;glucose metabolism;Gnotobiotic;gut inflammation;histone modification;Histones;Hyperactivity;Immune response;Immune system;Immunity;Immunologics;immunomodulatory therapies;Immunotherapy;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Intestines;Lactate Transporter;Lactic acid;Lactobacillus;Link;Malignant Neoplasms;Measurement;Metabolic;Metabolic Control;metabolic profile;Metabolism;microbiota;Modeling;mouse model;Mus;Normal tissue morphology;novel;Nutrient;Pathology;Pathway interactions;Peripheral;Play;Predisposition;Regulatory T-Lymphocyte;Role;Shapes;Site;Small Intestines;Supporting Cell;System;T-Cell Proliferation;T-Lymphocyte;Tissues;tool;transcription factor;tumor;tumor microenvironment;Tumor-Derived;uptake;Work

PROJECT_TITLE: Metabolic control of regulatory T cell functional identity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: T3D THERAPEUTICS, INC.

ORG_STATE: NC

PHR: PROJECT NARRATIVE This research advances the development to market of a new therapeutic drug, T3D-959, that could enhance the health and reduce disability of Alzheimer’s patients, which in turn, could significantly reduce the healthcare cost burden of Alzheimer’s disease (AD). The innovative approach, educed by T3D-959, to improving cognition and function through correction of dysfunctional brain metabolism inherent in the disease, will enhance our knowledge of AD pathogenesis and provide insights into new avenues for AD drug development.

PI_NAMEs: DIDSBURY, JOHN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Advanced Development;Agonist;Agreement;Alzheimer's Disease;Alzheimer's disease patient;Amyloid beta-Protein;Animals;Area;arm;Biological Markers;Blinded;brain dysfunction;brain metabolism;carcinogenicity;Carcinogenicity Tests;CD3D gene;Clinical;clinical development;Cognition;Data;data submission;design;disability;Disease;Dose;Double-Blind Method;drug candidate;drug development;Drug Exposure;Energy Metabolism;Ensure;Equilibrium;executive function;Funding;glucose metabolism;Goals;Guidelines;Health;Health Care Costs;Homeostasis;Human;improved;Inflammation;innovation;insight;Investigational Drugs;Knowledge;Life;lipid metabolism;Marketing;Measures;Metabolic;Multicenter Trials;neurofibrillary tangle formation;new chemical entity;novel therapeutics;Nuclear Receptors;Oral;Outcome;Outcome Measure;Pathogenesis;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 3 testing;Phase II Clinical Trials;Phase III Clinical Trials;Placebo Control;Placebos;Plasma;pre-clinical;primary outcome;protein misfolding;Protocols documentation;Radiolabeled;Randomized;Rattus;Reporting;Research;research and development;research clinical testing;Research Design;Risk;Rodent;Safety;secondary outcome;Severities;Signal Transduction;Small Business Innovation Research Grant;small molecule;statistics;success;Test Result;Tissues;Toxicokinetics;tumor;tumorigenic;United States National Institutes of Health;Work

PROJECT_TITLE: Clinical Development Enablement – Long Term Rodent Testing of the Carcinogenic Potential of the Alzheimer’s Disease Drug Candidate T3D-959

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-P(11)B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Digestive Diseases;Immunotherapy;Liver Cancer;Liver Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This grant is aimed at enhancing our ability to study and assess liver cancer treatment using locoregional therapy in combination with systemic immune therapy. At the core of this effort is the unmet need for advanced imag- ing which can track the combined locoregional and immune therapies, and to that end we will develop, evaluate and translate advanced imaging, machine learning and image analysis methods to predict and assess clinical outcome with non-invasive imaging biomarkers based on characterization of liver tumor microenvironment. The resulting predictions and assessments will lead to improved patient care through more informed treatment strati- ﬁcation and clinical decision making.

PI_NAMEs: CHAPIRO, JULIUS ;DUNCAN, JAMES S (contact);MADOFF, DAVID C

PROGRAM_OFFICER_NAME: DARDZINSKI, BERNARD JOSEPH

PROJECT_TERMS: Acidosis;Adjuvant;Aftercare;Arteries;automated segmentation;Biological Markers;biomarker development;Biopsy Specimen;Biosensor;Cancer Etiology;cancer therapy;Catheters;Cell Density;Cells;Cellularity;Cessation of life;Chemoembolization;chemotherapy;Classification;Clinical;clinical decision-making;clinical outcome assessment;Clinical Treatment;cohort;Collaborations;Combination immunotherapy;Combined Modality Therapy;cone-beam computed tomography;contrast enhanced;convolutional neural network;Data Pooling;Decision Making;deep learning;design;Development;Environment;extracellular;feeding;Goals;Grant;Graph;graph neural network;Guidelines;Habitats;Hepatocyte;Human;Image;Image Analysis;image guided;image registration;imaging biomarker;imaging informatics;Immune;immune activation;Immune checkpoint inhibitor;Immune response;Immune system;Immunobiology;Immunologics;Immunotherapy;improved;in vivo;Individual;innovation;Intervention;intrahepatic cancer;ischemic injury;Joints;Learning;Lesion;Liver;liver cancer model;Liver neoplasms;Machine Learning;machine learning method;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;magnetic resonance spectroscopic imaging;Malignant neoplasm of liver;Malignant Neoplasms;Manuals;Maps;Measurement;Measures;Medical Oncology;Metabolic;metabolic imaging;Metabolism;Methods;minimally invasive;Modality;Modeling;Multimodal Imaging;Neoadjuvant Therapy;neoplastic cell;New Zealand;non-invasive imaging;novel;novel strategies;Oryctolagus cuniculus;Outcome Assessment;outcome prediction;Palliative Care;Pathology;Patient Care;Patients;Pattern;permissiveness;Phase;Phenotype;pre-clinical;predicting response;Primary carcinoma of the liver cells;Primary Malignant Neoplasm of Liver;radiomics;random forest;recruit;Recurrence;Resolution;response;spatiotemporal;spectroscopic imaging;Standardization;Structure;Therapeutic;therapy outcome;Time;Tissues;Translating;treatment strategy;treatment stratification;tumor;tumor microenvironment;tumor progression;Tumor Volume;Western World;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative Multimodal Imaging Biomarkers for Combined Locoregional and Immunotherapy of Liver Cancer

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Lung Cancer;Patient Safety;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE Smoking is both common among adult patients with cancer and undertreated, despite strong evidence that quitting smoking markedly improves the health of cancer patients and survivors. Too few patients with cancer who smoke are offered and provided effective smoking treatment by their cancer care teams. The proposed research will identify and disseminate effective and feasible smoking treatment programs for cancer centers to increase the rates at which cancer patients who smoke quit smoking and improve their cancer recovery.

PI_NAMEs: FIORE, MICHAEL C (contact)

PROGRAM_OFFICER_NAME: REYES-GUZMAN, CAROLYN

PROJECT_TERMS: Acceleration;Adult;cancer care;Cancer Center;Cancer Etiology;Cancer Patient;Cancer Prognosis;Cancer Survivor;cancer therapy;Caring;cigarette smoking;clinical care;contextual factors;cost;cost effectiveness;Data;demographics;design;Effectiveness;Electronic Health Record;Equity;evidence base;experience;Health;Health Care Costs;implementation context;implementation strategy;improved;Intervention;intervention delivery;Malignant Neoplasms;Methods;Modification;National Cancer Institute;NCI-Designated Cancer Center;Oncology;Outcome;patient engagement;Patients;Policies;pragmatic implementation;Primary Care;Principal Investigator;Program Effectiveness;programs;Recovery;Research;Senior Scientist;Smoke;Smoking;smoking cessation;Smoking Cessation Intervention;Smoking treatment;System;tool;Treatment outcome;treatment program

PROJECT_TITLE: Leveraging the National Cancer Institute’s Cancer Center Cessation Initiative (C3I) Program to Evaluate and Transform Smoking Cessation Treatment in Cancer Care


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_DEPT: CHEMISTRY

PHR: Project Narrative The acquisition of the proposed target technology has wide-ranging biomedical implications because it will enable the atomic-resolution analysis of biomedically relevant molecules in solution at high sensitivity. This goal is highly in tune with both the basic-science and medically relevant applications promoted by the National institute of General Medical Sciences.

PI_NAMEs: CAVAGNERO, SILVIA  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: 3-Dimensional;Address;Amino Acids;Basic Science;Buffers;Carbon;Cells;Client;Communities;Data Collection;Dependence;detection sensitivity;Development;Development Plans;Devices;Disease;Dyes;Exhibits;experimental study;Funding;Goals;high dimensionality;improved;Investigation;Isotope Labeling;light emission;Liquid substance;magnetic field;Medical;Methodology;Methods;Molecular Chaperones;molecular dynamics;Molecular Structure;nanomolar;National Institute of General Medical Sciences;new technology;NMR Spectroscopy;novel;Nuclear;Nuclear Magnetic Resonance;Peptides;Photosensitizing Agents;Physiologic pulse;Protein Analysis;Proteins;rapid detection;Reporting;Research;Resolution;Sampling;Scheme;Solvents;Spectrum Analysis;Structure;success;Technology;technology development;Temperature;Testing;Time;tool;Tryptophan;Variant;Vertebral column;Viscosity;Work

PROJECT_TITLE: Development of LED-Assisted NMR Technologies for the Atomic-Resolution Analysis of Medically Relevant Biomolecules in Solution at Submicromolar Concentration

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Neurosciences;Pediatric

ORG_CITY: EVANSTON

ORG_NAME: ENDEAVOR HEALTH CLINICAL OPERATIONS

ORG_STATE: IL

PHR: There are growing number of indications that anesthesia-induced neurotoxicity is a serious threat to human health. This proposal studies the relationship between brain tissue oxygen regulation and learning deficiency in adulthood due to anesthesia exposure in infancy.

PI_NAMEs: AKSENOV, DANIIL  (contact)

PROJECT_TERMS: Adolescence;Adult;Affect;Age;Anesthesia procedures;Animals;awake;Axon;behavior test;Behavioral;behavioral deficiency;Brain;brain tissue;Cell Count;Child;Childhood;Clinical;Cognitive;Control Groups;Data;Development;diagnostic biomarker;diagnostic tool;Diffusion Magnetic Resonance Imaging;early detection biomarkers;Electrophysiology (science);Excitatory Amino Acid Antagonists;Exposure to;Frequencies;Functional Magnetic Resonance Imaging;Future;GABA Antagonists;General Anesthesia;Goals;Halorhodopsins;Health;hippocampal pyramidal neuron;Hippocampus;Human;Hyperoxia;Impairment;Individual;Induction of Apoptosis;infancy;Interneurons;Laser-Doppler Flowmetry;Learning;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Methods;Microinjections;Neonatal;neuron development;Neurons;neurotoxicity;neurovascular;optogenetics;Oryctolagus cuniculus;Oxygen;patch clamp;pharmacologic;Physiological;Predictive Value;Preventive treatment;Publishing;Pyramidal Cells;receptor;Regulation;Rest;Signal Transduction;Somatosensory Cortex;Testing;Time;tool;Visualization;Work

PROJECT_TITLE: Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Urinary tract infection (UTI), one of the most prevalent bacterial infections, is caused primarily by uropathogenic Escherichia coli (UPEC) and it is recalcitrant to treatment due to the ability of UPEC to form biofilms on catheters and host cells. The work proposed in the attached application expands on our recent findings demonstrating that UPEC uses the high-affinity quinol oxidase cytochrome bd to respire aerobically during infection and that deletion of cytochrome bd alters UPEC biofilm susceptibility to antibiotic treatment. In collaboration with Vanderbilt’s institute for chemical biology, we propose the use of synthesized cytochrome bd-specific inhibitors to evaluate the potential of preventing the establishment of UPEC biofilms on catheter material (aim 1) or, altering the architecture of pre-formed biofilms to increase the efficacy of antibiotics (aim 2).

PI_NAMEs: HADJIFRANGISKOU, MARIA  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Aerobic;Affect;Affinity;Anaerobic Bacteria;Antibiotic Therapy;Antibiotics;Architecture;Attenuated;Bacteria;bacterial community;Bacterial Infections;Biology;Bladder;Catheterization;Catheters;cell community;Cell Respiration;Cells;Cellulose;Chemicals;Chemosensitization;Code;Collaborations;Complex;copper oxidase;cytochrome c;cytochrome c oxidase;Cytochromes;Cytosol;Defect;Effectiveness;efficacy testing;Environment;Epithelial Cells;Epithelium;Escherichia coli;Exhibits;Extracellular Matrix;Genes;Goals;Growth;Heme;Hypoxia;Impairment;In Vitro;Individual;Infection;Infective cystitis;inhibitor;Innate Immune Response;insight;Invaded;Link;Membrane;Membrane Potentials;Membrane Proteins;Microbial Biofilms;Minimum Inhibitory Concentration measurement;Mitochondria;Modeling;Molecular;Motility;mouse model;Mus;mutant;novel therapeutics;overexpression;Oxidases;Oxygen;pathogen;Pathogenesis;preclinical evaluation;Predisposition;prevent;Prevention strategy;Process;Proteins;Proton Pump;Proton-Motive Force;Pump;quinol oxidase;Respiration;respiratory;Role;stress tolerance;Surface;Testing;Therapeutic;therapeutic development;three dimensional structure;urinary;Urinary tract;Urinary tract infection;Urologic Diseases;Uropathogenic E. coli;Virulence Factors;Work

PROJECT_TITLE: Targeting cytochrome bd as an anti-biofilm strategy


NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Nutrition;Pediatric

ORG_DEPT: SURGERY

PHR: After massive intestinal resection, there are alterations in the gut barrier function, enhanced expression of genes involved with lipid signaling in the intestine, as well as severe liver injury and fibrosis. The overall goals of this project are to understand the contribution of intestinal lipid signaling to the genesis of advanced liver injury. This information is critical for the development of new therapies to save lives of children who have required massive intestinal resection.

PI_NAMEs: DAVIDSON, NICHOLAS O.;DING, LI ;RUBIN, DEBORAH C.;WARNER, BRAD WAYNE (contact)

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: absorption;Adult;Child;Childhood;Cholestasis;Chylomicrons;Cirrhosis;Comprehensive Health Care;cytokine;Cytoplasmic Protein;Development;Dietary Fats;Dyslipidemias;economic impact;endoplasmic reticulum stress;Enteral;Enteral Feeding;Enterocytes;Etiology;Excision;Failure;fat nutrition study;Fatty Liver;Fibrosis;Gene Expression;Generations;Genomics;Goals;Hepatic;Hepatitis;Human;Hypertension;Impairment;Incidence;infancy;Inflammation;inflammatory milieu;Injury;insight;Insulin Resistance;Intestinal permeability;Intestines;Length;lipid biosynthesis;lipidomics;Lipids;Liver;Liver diseases;Liver Fibrosis;liver injury;long chain fatty acid;Membrane;Metabolic syndrome;metabolomics;mitochondrial dysfunction;Morbidity - disease rate;mortality;mouse model;Mus;Necrosis;Nodule;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nonesterified Fatty Acids;novel;novel therapeutics;Obesity;Omega-3 Fatty Acids;Omega-6 Fatty Acids;Parenteral Nutrition;Pathogenesis;Pathway interactions;Patients;pediatric patients;Primary carcinoma of the liver cells;Procedures;Production;Proteins;Reactive Oxygen Species;regenerative;Resected;response;Role;Sepsis;Short Bowel Syndrome;Signal Transduction;Signaling Molecule;Site;Small Intestines;Starvation;Survivors;Time;TLR4 gene;transcription factor;Transplantation;Venous;Visceral

PROJECT_TITLE: Intestinal Resection Associated Liver Injury and Fibrosis

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE (RELEVANCE)  This project will take an integrative approach involving generating a 4D atlas of regulatory interactions during both development and disease progressions, computationally nominating diabetes-relevant β cell enhancers through integrative analysis and discovering functional enhancers through large-scale perturbation screens. Knowledge gained from the study will provide a conceptual framework for dissecting gene regulatory networks that instruct the β cell fate and function during development and in diabetic conditions.

PI_NAMEs: APOSTOLOU, EFFIE ;HUANGFU, DANWEI  (contact);LESLIE, CHRISTINA S

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;ATAC-seq;Atlases;Beta Cell;Binding;Biological Assay;Biology;causal variant;Cell Line;Cell Reprogramming;cell type;Cells;Chromatin;chromatin immunoprecipitation;chromosome conformation capture;clinical application;Clinical Data;Complex;Computational Biology;Computing Methodologies;CRISPR interference;Data;Development;Diabetes Mellitus;diabetes pathogenesis;diabetic;directed differentiation;Disease;Disease Progression;Embryonic Development;endocrine pancreas development;Enhancers;Ensure;Gene Expression;gene function;gene regulatory network;Genes;Genetic Transcription;Genome;genome wide association study;Genomic approach;genomic data;Genomics;Goals;Health;Hi-C;histone modification;Homeostasis;Human;Human Development;human disease;Human Genetics;human pluripotent stem cell;improved;innovation;innovative technologies;insight;interest;islet;Islet Cell;Islets of Langerhans;Knowledge;Link;machine learning model;Malignant Neoplasms;Maps;Mediating;multidisciplinary;Mus;Mutation;Names;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleic Acid Regulatory Sequences;Pathogenicity;Pathologic;Population;precursor cell;programs;promoter;Publishing;Regulatory Element;Research Personnel;Resolution;screening;Somatic Cell;Specificity;Time;Tissues;tool;transcription factor;Translating;Untranslated RNA;Update;Validation;Variant;Work

PROJECT_TITLE: Discovery of diabetes-relevant ÃÂ² cell enhancers through 4D enhancer mapping, integrative analysis, and large-scale CRISPRi perturbation screens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(70)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Breastfeeding, Lactation and Breast Milk;Clinical Research;Dementia;Maternal Health;Neurodegenerative;Neurosciences;Nutrition;Pregnancy;Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Our study is uniquely designed to unravel some of the complexities of sex-specific dementia risk by conducting the most rigorous examination to date of the associations between women’s histories of pregnancy and breastfeeding with the etiological processes that contribute to Alzheimer’s disease and related dementias (ADRD). Understanding the relationships of women’s pregnancy and breastfeeding histories with ADRD-related pathology is critical for identifying at-risk post-menopausal women. Similar to what has been developed for breast cancer, our research program will work towards developing post-menopausal women’s ADRD risk assessment tools based on reproductive history.

PI_NAMEs: FOX, MOLLY MAURER (contact)

PROGRAM_OFFICER_NAME: ANDERSON, DALLAS

PROJECT_TERMS: Address;adjudication;Adopted;Affect;Age;age related decline;Alleles;Alzheimer's disease related dementia;Amyloid beta-Protein Precursor;Anatomy;Animals;Anthropology;apolipoprotein E-4;Assessment tool;Atrophic;Attenuated;Biological;Biological Markers;Biology;Birth;Brain;Breast Feeding;California;Cardiovascular system;carrier status;cerebral atrophy;child bearing;Classification;clinical diagnosis;clinical risk;Cognitive;Cognitive aging;cohort;Cohort Studies;cost efficient;critical period;Data;Data Sources;Dementia;dementia risk;density;Dependence;design;Detection;Disease;disorder risk;early life exposure;Elderly;empowerment;Endocrine;epidemiology study;estrogenic;Etiology;European ancestry;Event;Exhibits;experience;Fertility;follow-up;Funding;gender difference;Genetic Polymorphism;Geriatric Psychiatry;glucose metabolism;Gravidity;gray matter;Health;high risk;Hippocampus;hormone therapy;Hormones;Human;human old age (65+);Image;Immune;Impaired cognition;improved;interest;Interview;Ischemia;ischemic lesion;Lactation;Life;Life Cycle Stages;life history;life span;Life Style;Link;lipid metabolism;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammals;Measurement;Measures;Memory;men;Metabolic;Methodology;Methods;middle age;Modeling;morphometry;motherhood;Mothers;Neurocognitive;neuroimaging;Neurologic;Neuropathogenesis;neuropathology;neuroprotection;Neurosciences;novel;Outcome;parity;Participant;Pathogenesis;Pathology;Pathway interactions;Pattern;Phase;Phenotype;Physiological;Physiology;Pilot Projects;Population;Populations at Risk;Postmenopause;Postpartum Period;Pregnancy;pregnancy failure;Pregnancy Histories;pregnant;Prevention;proband;Process;programs;protective effect;Proxy;Recording of previous events;recruit;reproductive;Reproductive History;Research;resilience;resilience factor;Resources;Risk;Risk Assessment;Risk Factors;Rodent;Role;Sample Size;secondary analysis;sex;Sex Differences;Spontaneous abortion;Statistical Methods;Structure;System;Testing;Thick;Time;verbal;Verbal Learning;Visualization;Woman;Women's Health;Women's study;Work

PROJECT_TITLE: How women’s reproductive life-history relates to cognitive decline and neuropathology in Alzheimer’s disease and related dementias

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


FUNDING_MECHANISM: RESEARCH CENTERS

PHR: NARRATIVE Breast cancers can show various types of unstable genomes that can be readily identified by DNA sequencing. These cancers are the most lethal subtypes of breast cancer at the present time. The SPORE is designed to improve the outcome of patients by using the latest in genomic diagnostic tools and pathological evaluations, plus extend this new knowledge for therapeutic approaches to exploit the underlying genomic instability.

PI_NAMEs: POWELL, SIMON N. (contact)

PROGRAM_OFFICER_NAME: BASA JANAKIRAM, NAVEENA

PROJECT_TERMS: acquired drug resistance;Address;Area;Biological;Biological Models;Biology;biomarker development;Breast Cancer Risk Factor;cancer type;career;cell behavior;cell free DNA;cell growth;Cell Line;Cell model;Cell Survival;Cell Transplantation;cellular engineering;Cessation of life;Characteristics;Chromosomal Instability;Clinical;clinical application;clinical biomarkers;clinical development;Clinical Trials;Clinical Trials Design;Clustered Regularly Interspaced Short Palindromic Repeats;Core Facility;Correlative Study;design;Development;Diagnosis;diagnostic tool;Disease;Disease Outcome;disorder subtype;DNA;DNA sequencing;Enzymes;Estrogen receptor positive;Evaluation;Genes;Genetic;Genetic Screening;genetically modified cells;Genome;genome sequencing;Genomic Instability;genomic profiles;Genomics;Goals;Grouping;Growth;Heterogeneity;high risk;homologous recombination deficiency;Immune response;Immune signaling;improved;improved outcome;Incidence;innovation;insight;Institution;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Memorial Sloan-Kettering Cancer Center;Minnesota;Modeling;mouse model;Mutagenesis;Mutation;Neoplasm Metastasis;Neoplasm Transplantation;novel;novel strategies;novel therapeutics;Pathogenesis;Pathologic;patient derived xenograft model;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Process;Prognosis;programs;protein expression;Proteins;Recurrence;Reproduction spores;Research;Research Project Grants;Resistance development;Resolution;response;Risk Taking;Role;Sampling;Structure;success;targeted treatment;Testing;Therapeutic;therapeutic target;Time;translational goal;Translational Research;tumor;tumor behavior;Universities;whole genome

PROJECT_TITLE: MSK SPORE in Genomic Instability in Breast Cancer


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

PHR: NARRATIVE: The administrative core is the integrative hub of all the activities described in the SPORE. It makes sure the projects, cores and developmental programs are functioning as planned. It will stimulate interactive science between the projects and collaborations with other SPOREs and programmatic research and with other investigators within MSKCC.

PROJECT_TERMS: Advocate;Budgets;Cancer Patient;Collaborations;Communication;Communities;Development;Disease Management;editorial;Education;Educational Activities;Ensure;Environment;Fostering;Future;Genomic Instability;Grant;Human Resources;Infrastructure;Institution;Malignant Breast Neoplasm;Manuscripts;meetings;Memorial Sloan-Kettering Cancer Center;Mentors;Monitor;National Cancer Institute;Occupational activity of managing finances;patient population;Patients;Pilot Projects;programs;Publications;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Science;scientific organization;Services;Translational Research

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: STANFORD

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Chromatin dynamics, gene expression, and cellular decisions are tightly linked on both short timescales such as individual enhancer-promoter contacts, and longer ones involved in epigenetic memory across cell generations. Our understanding of chromatin dynamics is mostly limited to snapshots, making it difficult to predict its time evolution and effects on human health. Drawing on recent advances in synthetic epigenetic control, genetic locus labeling, super-resolution imaging, multiplexed microscopy, and polymer modeling, we aim to create a new imaging technology to study chromatin dynamics and gene expression across short and long time scales of cell differentiation.

PI_NAMEs: BINTU, LACRAMIOARA  (contact);BOETTIGER, ALISTAIR N.

PROJECT_TERMS: 3-Dimensional;Adopted;Algorithms;Amaze;Animals;Architecture;Back;Behavior;Biological Assay;Cell Cycle;Cell Differentiation process;Cell Fraction;Cell Line;Cell Lineage;Cell Physiology;Cells;cellular imaging;Chromatin;Chromatin Modeling;Chromatin Structure;cohesin;Collecting Cell;Color;Communities;Complex;Dancing;data modeling;Development;Disease;DNA;Dose;Engineering;Enhancers;epigenetic memory;Epigenetic Process;epigenome;Equilibrium;ES Cell Line;Evolution;Excision;experimental study;forgetting;Gene Activation;Gene Expression;Gene Expression Regulation;Generations;Genes;Genetic Transcription;Genome;genome-wide;genomic locus;Genomics;Health;Hi-C;Human;human embryonic stem cell;Human Genome;human induced pluripotent stem cells;Image;imaging approach;Imaging technology;Individual;innovation;Knock-in;Label;Ligation;Link;long term memory;Maps;Measurement;Measures;Mediating;Memory;Methods;Microfluidic Microchips;Microscopy;Modeling;Modification;Molecular;Monitor;Mouse Embryonic Stem Cells;Nature;Neighborhoods;Neural Crest;novel;novel imaging technology;Nuclear;Optics;particle;Phase;Polycomb;Polymers;Population;Positioning Attribute;Process;promoter;Proteins;reconstruction;recruit;Reporter;Reporter Genes;Research;RNA;Role;Shapes;Signal Transduction;Sister;stem;Structure;superresolution imaging;superresolution microscopy;System;Techniques;Technology;Testing;Theoretical model;three dimensional structure;Time;tool;Transcript;Transcriptional Regulation;ultra high resolution;Visualization;Work

PROJECT_TITLE: Live-cell multiplex super-resolution imaging of chromatin state transitions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(70)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Women's Health Research

PHR: NARRATIVE The overall goal of the Biostatistics and Computational Genomics Core is to ensure streamlined and customized services, support, and innovation in data processing, analysis, storage, and visualization; the design of laboratory experiments and validation; the design and analysis of prospective cohort studies and clinical trials, and to assist the SPORE investigators in the achievement of their scientific and translational goals of the research projects.

PI_NAMEs: SHAH, SOHRAB P (contact)

PROJECT_TERMS: Achievement;Address;analysis pipeline;Animals;Bioinformatics;bioinformatics tool;Biological Specimen Banks;biomarker development;biomarker validation;Biometry;cancer genome;cancer genomics;cBioPortal;CDK4 gene;cell type;Cells;Chromosomal Instability;Chromosomes;clinical care;Clinical Data;Clinical Research;clinical trial analysis;Clinical Trials;clinically significant;Cluster Analysis;Collection;Computational Biology;Computer Analysis;computerized data processing;computerized tools;Computing Methodologies;Data;Data Analyses;Data Collection;data integration;Data Sources;Databases;Dedications;Defect;Deposition;design;Development;Dimensions;Disease;diverse data;DNA;DNA Repair;DNA Repair Disorder;DNA sequencing;Ensure;Estrogen receptor positive;exome;experience;fitness;follow-up;Formulation;Genetic;genome sequencing;genomic data;Genomic Instability;genomic signature;Genomics;Goals;Heterogeneity;High Performance Computing;homologous recombination;Hormones;Human;Human Resources;Immune;Immunocompetent;Infrastructure;innovation;Institution;laboratory experiment;Laboratory Research;Length;Link;Maintenance;Malignant Breast Neoplasm;Mediating;member;Memorial Sloan-Kettering Cancer Center;Metadata;Metastatic breast cancer;Methods;Modeling;Molecular;mouse model;multimodality;multiple data sources;Mutation;neoplastic cell;next generation sequencing;novel;online resource;Pathology;patient derived xenograft model;Patients;Periodicity;Phenotype;preclinical study;Prevalence;Procedures;Prospective, cohort study;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;research study;Resistance;Resources;RNA;Sample Size;Sampling;Scientist;Services;single cell sequencing;Single Nucleotide Polymorphism;single-cell RNA sequencing;Space Models;Specimen;Statistical Algorithm;Statistical Data Interpretation;Statistical Methods;Stratification;success;synergism;telomere;Time Series Analysis;tool;transcriptome;transcriptome sequencing;translational goal;tumor;tumor-immune system interactions;Validation;Variant;Visualization;whole genome;Work

PROJECT_TITLE: Bioinformatics and Biostatistics Data Analysis Core


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Genetics;Women's Health Research

PHR: PROJECT NARRATIVE The Biopsecimen Repository and Pathology Core will facilitate and expedite the collection, annotation, storage, distribution, and digital archiving and processing of biospecimens from patients with breast cancers displaying specific patterns of DNA repair defects and/or genetic instability, provide histopathology, molecular pathology and multiplexed immunophenotyping expertise and support for the seamless and timely execution of the SPORE Research Projects.

PI_NAMEs: PLITAS, GEORGE  (contact)

PROJECT_TERMS: Aftercare;Animal Model;Archives;Artificial Intelligence;biobank;Biological Assay;Biological Specimen Banks;Blood;Breast;Breast Cancer Model;Breast Cancer Patient;cell free DNA;central database;Chromosomal Instability;Clinical;Collection;Communities;comparative;Comparative Pathology;data mining;Dedications;Defect;design;Development;Diagnosis;digital;digital imaging;DNA Repair;Drug or chemical Tissue Distribution;Ensure;Evaluation;experience;Formalin;Freezing;Generations;Genetic;Genetically Engineered Mouse;Genomic approach;Genomic Instability;Guidelines;Histopathology;Human;imaging platform;immune cell infiltrate;Immunofluorescence Immunologic;Immunohistochemistry;Immunooncology;Immunophenotyping;Individual;Infrastructure;Institution;Institutional Review Boards;Laboratories;Malignant Breast Neoplasm;Memorial Sloan-Kettering Cancer Center;Metastatic breast cancer;Microdissection;molecular pathology;mouse model;multiplexed imaging;Mus;neoplastic cell;Normal tissue morphology;novel;Nucleic Acids;Paraffin Embedding;participant enrollment;Pathologic;Pathologist;Pathology;patient derived xenograft model;Patients;Pattern;peripheral blood;Phenotype;Pilot Projects;Preparation;Protocols documentation;repository;Research;Research Personnel;Research Project Grants;research study;Resources;Sampling;Scientist;Services;Standardization;System;Tissue Embedding;Tissue Microarray;tissue processing;Tissue Procurements;Tissue Sample;Tissues;Translational Research;tumor;tumor microenvironment

PROJECT_TITLE: Biospecimen Repository and Pathology Core


NIH_SPENDING_CATS: Aging;Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Precision Medicine;Radiation Oncology;Women's Health Research

PHR: Narrative This project asserts that there at least two different patterns of genome instability for double-strand break repair. One is focused on the function of the BRCA1-BRCA2 pathway, where alterations in function are actually quite common; the second is focused on upstream sensing of DNA damage, which is another way to suppress cancer formation. Upstream defects are best targeted by the use of replication checkpoint inhibitors, but that BRCA defective tumors are best treated by targeting the backup pathway, such as PARP-inhibitors or new agents beyond PARP-inhibitors.

PROJECT_TERMS: 4T1;Affect;Aging;Alleles;Biological Process;brca gene;BRCA1 gene;BRCA2 gene;breast cancer genomics;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;Breast Epithelial Cells;breast tumorigenesis;Categories;Cell Line;Cell Survival;Cells;CHEK2 gene;Classification;Clinical;Clinical Data;Clinical Trials;Clinical Trials Design;Complex;Correlative Study;Cytosine deaminase;Cytotoxic agent;cytotoxic radiation;Defect;Development;Disease;DNA Damage;DNA Repair;DNA Repair Disorder;DNA Repair Pathway;DNA Sequence Alteration;Double Strand Break Repair;ds-DNA;Engineering;Estrogen receptor positive;Event;Excision;Frequencies;Gene Mutation;gene repair;Genes;Genetic;genetically modified cells;Genome;genome sequencing;Genomic Instability;genomic signature;Genomics;Genotype;Germ Lines;Goals;homologous recombination;homologous recombination deficiency;Human;Immune checkpoint inhibitor;Immune system;improved;improved outcome;inhibitor;Interruption;Lead;Length;Link;Malignant Breast Neoplasm;Malignant Neoplasms;MCF10A cells;MCF7 cell;Memorial Sloan-Kettering Cancer Center;Metastatic breast cancer;Methods;mouse model;Mus;mutant;Mutation;neoplastic cell;New Agents;Non-Malignant;Nonhomologous DNA End Joining;PALB2 gene;Pathway interactions;patient prognosis;Patient Selection;Patients;Pattern;personalized medicine;Play;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;Proteins;Radiation therapy;Recovery;repaired;response;Role;Sequence Deletion;Signal Transduction;stem;Subgroup;System;T47D;targeted treatment;Taxonomy;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;treatment response;tumor;tumor DNA;whole genome

PROJECT_TITLE: Defining and Targeting Homologous Recombination Deficiency in Breast Cancer


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Among humans, aggression levels vary between individuals and are exaggerated in many with neuropsychiatric conditions. The expression of aggressive traits is highly heritable, yet the genetic basis of aggression is largely unknown. Here, I propose to use Siamese fighting fish, which have been long selected for aggressive traits, to identify genes and neural circuits modulating aggression.

PI_NAMEs: SHIH, PEI YIN  (contact)

PROGRAM_OFFICER_NAME: JONES, LATAISIA CHERIE

PROJECT_TERMS: 3D Print;Affect;Aggressive behavior;Amygdaloid structure;Animal Behavior;Animals;autism spectrum disorder;base;Behavior;behavior test;Behavioral;behavioral response;brain behavior;Brain region;Breeding;career;career development;Cessation of life;Chromosome Mapping;Classification;Code;CRISPR/Cas technology;Custom;Data;Development;Development Plans;Economic Burden;erection;Etiology;Excitatory Synapse;Faculty;falls;fighting;Fishes;Foundations;Frequencies;gain of function;gene discovery;Generations;Genes;Genetic;genetic approach;genetic variant;Genetic Variation;Genomics;Gills;Goals;Heritability;Human;Image;Individual;Individual Differences;Infrastructure;Inhibitory Synapse;innovation;insight;interdisciplinary approach;interest;Knock-out;Knowledge;Lung;Machine Learning;Maintenance;Maps;Mediating;Mentorship;Methods;Mind;Modeling;Molds;Molecular;Mollies;Mus;Nervous System;neural;neural circuit;Neurobiology;neuroligin 3;neuronal circuitry;Neurons;neuropsychiatry;novel;novel strategies;overexpression;Partner in relationship;Pathway interactions;Pattern;Performance;Phase;Physiological;Population Genetics;Positioning Attribute;Quantitative Trait Loci;Recording of previous events;Research;Research Activity;Research Personnel;Resource Development;Resources;Robot;Ruta;Shapes;siamese fighting fish;Signal Transduction;skills;Social Behavior;Societies;Specific qualifier value;Statistical Methods;Synapses;System;Techniques;Technology;Testing;tool;Tracer;trait;Transgenic Organisms;Variant;visual stimulus;Work

PROJECT_TITLE: Genetics and neurobiology of aggression of Betta splendens


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Precision Medicine;Prevention;Women's Health Research

PHR: PROJECT NARRATIVE Chromosomal instability (CIN) is a hallmark of aggressive breast cancer, yet how it contributes to the ability of cancer cells to resist therapy and spread to distant organs remains poorly understood. Our research identified that CIN promotes aggressive cancer behavior by sustaining chronic inflammation. Here, we will exploit this finding to test whether a tool compound that inhibits inflammation can suppress breast cancer metastasis and to develop novel biomarkers predictive of response to chemotherapies and immunotherapies already approved for the treatment of breast cancer.

PI_NAMEs: BAKHOUM, SAMUEL F (contact)

PROJECT_TERMS: Address;Adenosine;Adjuvant Chemotherapy;aggressive breast cancer;Autophagocytosis;Behavior;Biological Markers;Biological Specimen Banks;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Model;Breast Cancer Treatment;cancer cell;cancer subtypes;cancer therapy;Cell Death;Cell Physiology;Cell Senescence Induction;Cells;Cellular Immunity;chemotherapy;Chromosomal Instability;chromosome missegregation;Chromosome Segregation;Chromosomes;Chronic;Clinical;Colon Carcinoma;Cyclic AMP;Cytoplasm;Cytosol;Cytotoxic Chemotherapy;Data;Development;Disease;Distant;DNA;ds-DNA;ecto-nucleotidase;Encapsulated;Epithelial Cells;Exposure to;extracellular;Extracellular Space;first-in-human;Flow Cytometry;Generations;genetic manipulation;Genomic DNA;Genomic Instability;Genomics;Goals;Human;Hydrolysis;Immune;Immune Evasion;Immune signaling;Immunohistochemistry;Immunologic Surveillance;Immunophenotyping;Immunosuppressive Agents;Immunotherapeutic agent;Immunotherapy;Inflammation;Inflammatory;inhibitor;innate immune pathways;Interferon Activation;Interferon Type I;Interferons;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;Melanoma;Metabolic;Metastatic breast cancer;Metastatic/Recurrent;Microdialysis;micronucleus;Mitosis;Modeling;mouse model;Mus;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel marker;novel therapeutic intervention;Nuclear;Organ;Paclitaxel;Pathologic;Pathology;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;pharmacologic;pre-clinical;Preclinical Testing;predicting response;Prediction of Response to Therapy;predictive marker;prevent;prospective;Recurrence;Research;Resistance;response;response biomarker;Role;Rupture;Sampling;Second Messenger Systems;senescence;Signal Transduction;single-cell RNA sequencing;Source;Specimen;Stimulator of Interferon Genes;System;T-Lymphocyte;Techniques;Testing;Therapeutic;therapy resistant;tool;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Subtype;tumor-immune system interactions;Validation;Viral;viral DNA;Work;Xenograft procedure

PROJECT_TITLE: Targeting innate immune pathways in breast cancers with chromosomal instability


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Estrogen;Genetics;Human Genome;Women's Health Research

PHR: Relevance: Metastatic breast cancer is one of the leading causes of death among women in the United States with mortality linked to the disease becoming resistant to hormonal therapies. Analyses of breast cancers that are metastatic reveal the presence of pathogenic DNA mutations originating from the mutagenesis process induced by the activity of the APOBEC family of antiviral enzymes. This project will facilitate clinical identification of cancers in which APOBEC is or will become active, elucidate how APOBEC promotes drug resistance, and develop new methods for treating APOBEC positive tumors.

PI_NAMEs: CHANDARLAPATY, SARAT  (contact)

PROJECT_TERMS: acquired drug resistance;Affect;antagonist;Aromatase Inhibitors;Benchmarking;Biochemistry;Bioinformatics;Biological Assay;Biological Markers;Biological Models;Breast Cancer cell line;breast cancer diagnosis;Breast Cancer Model;Breast Cancer therapy;cancer cell;cancer genome;Cancer Model;cancer therapy;Caring;Cause of Death;CDK4 gene;Cell Cycle Inhibition;cell free DNA;Cell Line;Cells;Cessation of life;Characteristics;chromatin remodeling;Clinic;Clinical;Clinical Trials;Comparative Genomic Analysis;CRISPR/Cas technology;curative treatments;Data;Data Set;Dependence;deprivation;Detection;Development;Diagnosis;Disease;Disease Resistance;Disseminated Malignant Neoplasm;DNA Damage;DNA Repair;DNA Sequence Alteration;dominant genetic mutation;Drug Combinations;Drug resistance;Eligibility Determination;Endocrine;Enzymes;ERBB2 gene;ESR1 gene;Estrogen Antagonists;Estrogen receptor positive;Estrogen Receptors;Estrogens;Family;FAT gene;Genes;Genetic;Genomic Instability;genomic profiles;Genomics;hormone therapy;immune checkpoint blockade;Immune response;Immunohistochemistry;Immunologics;Individual;inhibitor;innovation;insight;Kinetics;knock-down;Knock-out;Large-Scale Sequencing;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Medical;Metastatic breast cancer;Methods;Minority;Modeling;mortality;multimodality;Mutagenesis;Mutagens;Mutation;Neoplasm Metastasis;Newly Diagnosed;next generation sequence data;NF1 gene;novel strategies;overexpression;Pathogenesis;Pathogenicity;patient derived xenograft model;Patients;Pattern;Phenotype;Positioning Attribute;Prevalence;prevent;Primary Neoplasm;Process;RB1 gene;Recurrence;refractory cancer;Regimen;Resistance;resistance allele;Resistance development;resistance mutation;Sampling;Series;Shapes;Systemic Therapy;Tamoxifen;Testing;Therapeutic;therapeutic target;Time;transcription factor;Translating;tumor;tumor DNA;tumor progression;United States;Viral;Women's mortality

PROJECT_TITLE: Diagnosis and Treatment of APOBEC Mutagenesis in Metastatic Breast Cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy

ORG_CITY: HERSHEY

ORG_NAME: PENNSYLVANIA STATE UNIV HERSHEY MED CTR

PHR: Project Narrative Despite the knowledge that immune activation in spleen critically regulates physiological wound healing and pathological left-ventricular remodeling post-myocardial infarction, the specific mechanism that regulate this cross-talk are not known. Our preliminary results suggest an important role of TNFR1 expressing exosomes in shuttling cardiac-specific damage signals to the distant lymphoid tissues such as the spleen and subsequent immune-activation post-myocardial infarction. In the proposed study, PI intends to study the role of i) spleen in processing circulating exosomes, and ii) exosome specific TNFR1 expression in regulating pathological immune activation and left-ventricular remodeling.

PI_NAMEs: BANSAL, SHYAM SUNDER (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: Adoptive Transfer;Animal Model;Antigen-Presenting Cells;Antigens;Biology;Bone Marrow;Breeding;Cardiac;Cardiac Myocytes;Cardiovascular system;CD4 Positive T Lymphocytes;cell type;Cells;cellular targeting;Circulation;Clinical;Clinical Research;Clonal Expansion;Collaborations;Communication;Complex;Congestive Heart Failure;Data;Dendritic Cells;Disease Progression;Distant;Dyes;Echocardiography;EFRAC;Eotaxin;exosome;experience;Fibrosis;Functional disorder;Gene Expression;healing;Heart;Heart failure;heart function;Heart Injuries;hematopoietic tissue;Hypertrophy;Hypoxia;Immune;immune activation;immune modulating agents;Immune response;immunogenic;Immunology;immunoregulation;Incubated;Infarction;Infiltration;Inflammation;Inflammatory;Injections;intercellular communication;intravenous administration;intravenous injection;Ischemia;ischemic injury;Knowledge;Label;Left;Left Ventricular Remodeling;Left ventricular structure;Letters;Ligation;Lymphoid;Lymphoid Tissue;Macrophage;Measures;Mediating;Mediator;Membrane;Messenger RNA;MicroRNAs;Mitochondrial Proteins;Molecular;monocyte;Mus;Muscle Cells;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;Myocardium;Pathologic;Physiological;PKH 26;preclinical study;prevent;Proteins;Receptors, Tumor Necrosis Factor, Type II;Regulatory T-Lymphocyte;response;restraint;Role;S100A8 gene;S100A9 gene;Scientist;Severities;Signal Transduction;Signaling Molecule;Signaling Protein;Source;Spleen;Splenectomy;Splenocyte;T memory cell;T-Cell Activation;T-Lymphocyte;Testing;Tissues;TNFRSF1A gene;tool;trafficking;Tumor Necrosis Factor Receptor;Ventricular;Vesicle;wound healing

PROJECT_TITLE: TNFR1 Expressing Exosomes are Critical Mediators of Pathological Immune Activation in the Spleen post-Myocardial Infarction

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Human Genome;Prevention;Women's Health Research

PHR: Project Narrative/Relevance The goal of the Developmental Research Program (DRP) is to expand the investigator base and scope of translational research in breast cancer cancers with specific patterns of DNA repair defects and/ or genetic instability. We will use DRP funding supplemented by a strong commitment of institutional funds to support innovative projects by new and established investigators, which are critical to the generation of new directions in breast cancer research and to meet our translational objectives.

PROJECT_TERMS: Acceleration;Address;Advocate;anti-cancer research;arm;Attention;base;Benchmarking;Biological Markers;BRCA1 gene;BRCA2 gene;Breast Cancer Patient;Breast Cancer Prevention;Breast Cancer Treatment;Budgets;career;catalyst;CHEK2 gene;Chromosomal Instability;Chronology;Clinical;Committee Members;Communities;community center;Data;Defect;Development;Diagnosis;Disease;DNA Repair;Doctor of Philosophy;Ensure;Etiology;Fertilization;Fostering;Funding;Future;Generations;Genes;Genetic;Genomic Instability;genomic signature;Genomics;Goals;Grant;High Prevalence;high risk;homologous recombination;hormone receptor-positive;hormone therapy;Hospitals;innovation;Institution;Investigator-Initiated Research;Knowledge;Leadership;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Memorial Sloan-Kettering Cancer Center;Mentors;Molecular;Monitor;Mutagenesis;New York;optimal treatments;Pathway interactions;Patient Care;Patients;Pattern;Peer Review;Pilot Projects;Platinum;Play;Poly(ADP-ribose) Polymerase Inhibitor;predictive marker;Presbyterian Church;Prevention;Process;programs;Qualifying;Research;Research Personnel;Research Project Grants;Resources;Role;Salts;Selection Criteria;specific biomarkers;success;targeted agent;therapy resistant;translational cancer research;translational goal;translational potential;Translational Research;translational research program;treatment response;triple-negative invasive breast carcinoma;tumor;Universities;Voting

PROJECT_TITLE: Developmental Research Program


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Genetics;Infectious Diseases;Natural Products

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE (Public health relevance)  Antimicrobial resistance is a global health threat, predicted to cause ten million deaths and cumulative healthcare costs of $US100 trillion annually by 2050 if no new approaches are developed. This proposal seeks to obtain a mechanistic understanding of the acquisition of multidrug resistance. The results will have the potential to generate innovative strategies to reduce the spread of resistance determinants and restore the efficacy of MLS antibiotics.

PI_NAMEs: YAP, M.-N. FRANCES (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Address;Adenine;Affect;Antibiotics;antimicrobial;Antimicrobial Resistance;bacterial genetics;Bacterial Infections;bacterial resistance;Binding;Biochemical;Biochemistry;Biological Assay;Carotenoids;Catalysis;Cells;Cessation of life;Ciprofloxacin;Clinical;Communities;comparative genomics;Complex;constitutive expression;cost;Coupled;crosslink;Cryoelectron Microscopy;Crystallization;cytotoxic;Data;design;Disulfides;DNA Gyrase;Enzymatic Biochemistry;Enzymes;Evolution;Exhibits;experimental study;Family;fitness;gel mobility shift assay;Gene Expression;Generations;Genes;genetic approach;Genetic Polymorphism;Genetic Transcription;Genome;genome sequencing;global health;Goals;Gram-Positive Bacteria;Growth;Health Care Costs;human disease;human pathogen;Impairment;improved;In Vitro;in vivo;Infection;inhibitor;innovation;insight;Knowledge;Laboratories;lincosamide;Link;Macrolides;Maps;Mass Spectrum Analysis;Measures;Mediating;Medical;Messenger RNA;Methylation;Methyltransferase;Methyltransferase Gene;Mining;Modeling;Modification;Molecular;Multi-Drug Resistance;Mutation;next generation sequencing;novel strategies;Nucleotides;Operon;Pathway interactions;Peptides;Population;posttranscriptional;preference;Production;Protein Biosynthesis;Protein Inhibition;Proteome;Proteomics;public health relevance;Regulatory Pathway;Reporter;Resistance;resistance mechanism;Ribosomal RNA;ribosome profiling;Ribosomes;RNA;RNA Binding;Role;Site;Site-Directed Mutagenesis;Staphylococcus aureus;Streptogramins;structural biology;Structure;System;Testing;Therapeutic;Toll-like receptors;trait;Translations;translatome;Treatment Failure;Up-Regulation;virulence gene

PROJECT_TITLE: Evolution and consequences of multidrug resistant ribosome

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


PHR: Narrative: The Career Enhancement Program is designed to support the development of junior faculty by directed funds for pilot research projects and provide mentoring from experienced faculty in clinical and laboratory research. The result of this program will ensure a continuity of research excellence in breast cancer, particularly in how specific DNA repair defects and genetic instability patterns can be leveraged to tailor therapy of breast cancer patients.

PROJECT_TERMS: Adjuvant;Breast;Breast Cancer Patient;career;Career Choice;certificate program;Clinical;clinical application;clinical investigation;Clinical Investigator;Clinical Research;Clinical Sciences;comparative;Continuity of Patient Care;Defect;design;Development;Discipline;Disease;Disease Management;DNA Repair;Doctor of Philosophy;Ensure;Environment;experience;Faculty;faculty mentor;Funding;Genetic;Genomic Instability;Goals;Grant;Immunotherapy;Individual;individualized medicine;Institution;interest;Investigation;investigator training;Knowledge;Laboratories;Laboratory Research;Link;Malignant Breast Neoplasm;Malignant Neoplasms;member;Memorial Sloan-Kettering Cancer Center;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Metastatic breast cancer;Modeling;Oncology;Pathway interactions;Patient Care;Patients;Pattern;Physicians;Population;Population Sciences;Process;programs;recruit;Research;Research Personnel;Research Project Grants;Scientist;Source;Surgeon;targeted agent;targeted treatment;Training;translational cancer research;Translational Research;translational scientist;Translations;trend;United States National Institutes of Health;Work

PROJECT_TITLE: Career Enhancement Program


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: NARRATIVE Understanding the relationship between chromosome structure and cell fate decision is central to many biological questions. In this project, we propose to develop tools to capture dynamics of chromosome organization and chromatin states in single cells. The findings of this project will be key to understanding chromosome organization and its implications in human diseases.

PI_NAMEs: CAI, LONG  (contact);ELOWITZ, MICHAEL B;GUTTMAN, MITCHELL

PROJECT_TERMS: Address;Adopted;Antibodies;Biological;Biological Models;Cell Differentiation process;cell fixing;Cell Nucleus;Cells;Chromatin;chromatin modification;chromosomal location;Chromosome Structures;Chromosomes;Color;Coupled;CRISPR imaging;Data;DNA;Elements;Engineering;Epigenetic Process;Event;Fluorescent in Situ Hybridization;fluorophore;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;genome-wide;genomic locus;genomic tools;Genomics;Heterochromatin;Heterogeneity;Human Cell Line;human disease;Image;Imaging Device;Imaging technology;Immunofluorescence Immunologic;In Situ;Individual;insight;Introns;Kinetics;Label;Lamins;Link;Measurement;Measures;memory encoding;Messenger RNA;Methods;microscopic imaging;Molecular Conformation;Mouse Embryonic Stem Cells;Mutagenesis;Nature;Nuclear;Optics;Phase;pluripotency;Positioning Attribute;preservation;Process;Protein Dynamics;Proteins;reconstruction;red fluorescent protein;RNA;RNA analysis;sample fixation;scale up;Sister;Site;spatiotemporal;Structure;System;Techniques;Technology;telomere;Time;tool;Transcript;Trees;Visualization software;whole genome;Work;X Chromosome;X Inactivation

PROJECT_TITLE: Dynamics of chromosome organization and chromatin states in single cells


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: WILMINGTON

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, DELAWARE

ORG_STATE: DE

PHR: Principal Investigator/Program Director (Last, first, middle): Ross, Judith, M.D. Project Narrative Historically, there have been barriers to involvement of many children in the U.S. in state-of-the art pediatric clinical trials. The IDeA States Pediatric Clinical Trials Network (ISPCTN) represents a transformational opportunity to recruit more underserved children to participate in state-of-the-art clinical trials, facilitate implementation of well-designed pediatric clinical trials, and enhance pediatric clinical trial capacity within the IDeA state, Delaware (DE) at Nemours/Alfred I duPont Hospital for Children (AIDHC). The DE- Nemours/AIDHC site participation in the ISPCTN will catalyze new ideas, promote new collaborations, and will engage clinicians, researchers, and the community in well-designed pediatric clinical trials. Provision of this expertise and infrastructure will increase cutting edge clinical trial research with improved efficiencies for initiating and completing clinical trials and improved public health in DE and the Nation. PHS 398/2590 (Rev. 05/01) Page _______ Continuation Format Page

PI_NAMEs: AKINS, ROBERT E;ROSS, JUDITH L (contact)

PROGRAM_OFFICER_NAME: RAJU, TONSE N

PROJECT_TERMS: Address;Admission activity;African American;African American population;Area;Asthma;Biomedical Research;Centers of Research Excellence;Child;Child Health;Child health care;Childhood;Clinical;Clinical Practice Guideline;Clinical Research;clinical trial implementation;Clinical Trials;Clinical Trials Network;Collaborations;Communities;community engagement;Community Practice;Competence;Computerized Medical Record;Data;Database Management Systems;Delaware;design;Development;Discipline of obstetrics;Disease;Doctor of Medicine;Electronics;Ethnic Origin;experience;Family;Fostering;Good Clinical Practice;Health;high standard;Hispanic;Hispanic Populations;Hospitals;Human;implementation facilitation;improved;Infant;Infrastructure;Institutional Review Boards;interest;Latino Population;Life;Medicaid;Medical;Mission;mortality;Neonatal Abstinence Syndrome;neurodevelopment;novel;Obesity;operation;Outcome;Outcomes Research;Patient Care;Patient Recruitments;Pediatric Hospitals;pediatric patients;Pediatric Research;Physicians;Population;postnatal;Poverty;Poverty Areas;Premature Infant;Primary Care;primary care clinic;primary care practice;Principal Investigator;Procedures;Process;programs;Public Health;Qualifying;racial diversity;recruit;Research;Research Design;Research Infrastructure;Research Personnel;Resources;Rural;rural area;Rural Population;Scientist;Site;synergism;System;Talents;Textiles;Translational Research;Underserved Population;United States National Institutes of Health;Visit;web site;Work

PROJECT_TITLE: The DE Nemours/duPont Hospital for Children IDeA States Pediatric Clinical Trials Network Site


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Prevention

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative The goal of this application is to identify potently neutralizing and protective human monoclonal antibodies against SARS-CoV-2, which then could be rapidly developed into a therapy.

PI_NAMEs: BARIC, RALPH S;CROWE, JAMES E;DIAMOND, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;ACE2;Affinity;Alanine;Animal Disease Models;Antibodies;Antibody Therapy;Antigens;B-Lymphocytes;Binding;Biological Assay;Biology;Case Fatality Rates;Case Study;Cell Separation;Cessation of life;Charge;China;Chiroptera;Clone Cells;Combined Modality Therapy;community transmission;Containment;Coronavirus;Country;COVID-19;COVID-19 pandemic;Data;Death Rate;defined contribution;Deuterium;Development;Diamond;Disease;disease model;Elderly;Engineering;Epidemic;Epitopes;Evaluation;experience;experimental study;Fever;France;Generations;Germany;Glycoproteins;Goals;Half-Life;Human;human coronavirus;human monoclonal antibodies;Hydrogen;Immunocompromised Host;in vivo;Individual;Infection;Interferometry;Intervention;Iran;Italy;Laboratories;Licensing;Location;loss of function;Lung;Mass Spectrum Analysis;Mediating;Middle East Respiratory Syndrome Coronavirus;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;Mutagenesis;Natural Selections;neutralizing monoclonal antibodies;novel;novel coronavirus;pandemic disease;Pathogenicity;Pneumonia;prevent;Prevention;Prophylactic treatment;Proteins;receptor;RNA Viruses;SARS coronavirus;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 pathogenesis;Scanning;Serum;Severe Acute Respiratory Syndrome;Shotguns;Siblings;Somatic Mutation;Spain;Structure;Techniques;Technology;Testing;Therapeutic;Tissues;transmission process;United States;Vaccines;Variant;virtual;Virus;Virus Diseases;Virus Replication;Zoonoses;zoonotic coronavirus

PROJECT_TITLE: Human antibody-based countermeasures against the Wuhan Coronavirus SARS-CoV-2

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-N(90)S]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Kidney Disease;Precision Medicine

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE This proposed renewal will expand upon the first phase of a highly productive grant integrating metabolomic profiling and genetics in two cohorts of African Americans with chronic kidney disease. The renewal seeks to advance knowledge of biological pathways underlying chronic kidney disease by further integrating proteomic profiling as well as expanding metabolomic and proteomic work to a third cohort of patients with biopsy- confirmed kidney disease and adjudicated histopathology data. The overall goal is to improve the care of the 800 million patients worldwide with chronic kidney disease by enhancing mechanistic insight and clinical utility.

PI_NAMEs: GRAMS, MORGAN ERIKA (contact);RHEE, EUGENE P.;WAIKAR, SUSHRUT S.

PROGRAM_OFFICER_NAME: PARSA, AFSHIN

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;adjudication;adverse outcome;African American;African American population;Albuminuria;American;Amino Acids;Applied Genetics;Atherosclerosis Risk in Communities;Atrophic;biobank;Biological;Biological Assay;Biological Markers;Biological Process;biomarker identification;Biopsy;Blood;Blood Proteins;Boston;Caring;cell type;Cells;Chronic Kidney Failure;Clinical;Clinical Pathways;clinically relevant;cohort;Cohort Studies;Collaborations;Computerized Medical Record;Data;Development;Diagnosis;Dialysis procedure;Disease;Disease Marker;Disease Progression;Early Diagnosis;End stage renal failure;Etiology;Exhibits;Fibrosis;Functional disorder;Funding;Gene Expression;Genes;Genetic;Genetic Techniques;genome wide association study;genomic data;glomerular filtration;Glomerular Filtration Rate;glomerulosclerosis;Goals;Grant;Hand;Heterogeneity;high risk;Histologic;Histology;Histopathology;Hypertension;improved;Individual;Inflammation;innovation;insight;interest;interstitial;Investigation;Kidney;kidney biopsy;Kidney Diseases;Knowledge;Link;link protein;Measures;Mendelian randomization;Metabolic;metabolomics;Methods;multiple omics;novel;Outcome;Pathogenesis;Pathology;Pathway interactions;Patients;Phase;Plasma;podocyte;Population Heterogeneity;precision medicine;Procedures;Process;Productivity;Prognosis;protein biomarkers;Protein Biosynthesis;Proteins;Proteomics;Publications;Publishing;Quantitative Trait Loci;Renal function;Renal Replacement Therapy;Request for Proposals;Research;Research Personnel;Resolution;Risk;Role;Sclerosis;Severity of illness;statistics;Technology;therapeutic candidate;therapeutic target;Time;Tissues;Transplantation;Tubular formation;Variant;Visit;Work

PROJECT_TITLE: Multi-Omics and Chronic Kidney Disease: Correlation with Histology

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_DEPT: PSYCHIATRY

PHR: Narrative The University of Pittsburgh Autism Center of Excellence will fill a void in research on autistic adults and their mental health needs, including risk for suicide. We address this critical topic in authentic partnership with autistic adults and their allies, emphasize mechanistic translation, bring new researchers to work on autism, and provide an academic home for junior researchers getting started in this area. We will generate measures and mechanistic treatment targets that can be applied to improve safety and quality of life, and to reduce premature mortality for autistic adults.

PI_NAMEs: MAZEFSKY, CARLA A (contact)

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;affective neuroscience;Age;Aggressive behavior;Aging;aging biomarker;Ally;Area;autism spectrum disorder;autistic;Behavior;Behavioral;Biological;Biological Factors;Brain imaging;Child;Clinical;clinical care;cohort;Communities;community engaged research;comparison group;Computer Models;Control Groups;Data;data integration;design;Diagnosis;Diagnostic;Dimensions;Disease;Distress;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional experience;emotional stimulus;Emotions;Ensure;Equipment and supply inventories;ethnic identity;experience;Feeling suicidal;Female;Functional Magnetic Resonance Imaging;Funding;Future;Heterogeneity;high risk;Home;human old age (65+);improved;Impulsivity;indexing;Individual;Information Dissemination;innovation;International;Intervention;Life;Lived experience;longitudinal design;marginalization;Measurement;Measures;Mental Health;Methods;Mission;Modeling;Nature;neural;neural circuit;non-suicidal self injury;novel;older adult;Outcome;Patient Self-Report;Pattern;personalized care;Pharmaceutical Preparations;Phenotype;Physiological;Physiology;Premature Mortality;Prevalence;Prevention;primary outcome;Process;prospective;Psychiatric Diagnosis;Psychophysiology;Psychosocial Factor;Quality of life;Questionnaires;Race;recruit;reducing suicide;Regulation;Reporting;Reproducibility;Research;Research Domain Criteria;Research Methodology;Research Personnel;Resources;response;Rest;Rewards;Risk;Safety;Sampling;sensory stimulus;sex;Source;Speed;statistics;Stimulus;Structure;Subgroup;suicidal;suicidal morbidity;suicidal risk;Suicide;synergism;Testing;theories;therapy development;Time;Translations;Trauma;Universities;Work

PROJECT_TITLE: Mental Health in Autistic Adults: An RDoC Approach


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Suicide

PROJECT_TERMS: adult with autism spectrum disorder;Advocacy;Advocate;American;autism spectrum disorder;autistic;Biomedical Engineering;Budgets;Child;Clinical;Communication;Conflict of Interest;conflict resolution;Data;data archive;data management;Data Set;data sharing;data streams;data submission;Databases;Development;emotion dysregulation;Endowment;Ensure;Evaluation;Expenditure;Female;Funding;Goals;Guidelines;Helmet;human subject protection;Human Subject Research;Immigrant;life span;meetings;Mental Health;Monitor;National Institute of Mental Health;nonbinary;organizational structure;Parents;Policies;Procedures;professor;programs;Psychiatrist;Psychologist;Regulation;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Resources;Sampling;Schedule;Scientist;statistics;Suicide;Supervision;United States National Institutes of Health;Universities

PROJECT_TITLE: Mental Health in Autistic Adults:  An RDoC Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDIB-T]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Rural Health;Social Determinants of Health

PI_NAMEs: BECK, KELLY BATTLE (contact)

PROJECT_TERMS: adult with autism spectrum disorder;Advocate;Ally;Attention;autism spectrum disorder;autistic;Awareness;career;career development;Chronic;Clinic;Clinical;Color;Communication;Communities;community center;community engagement;community partners;community partnership;Continuing Education;cost;Dedications;Diagnosis;disadvantaged background;Environment;ethnic identity;Event;Family;Fellowship Program;Female;Festival;Financial Support;Generations;graduate student;health disparity;health inequalities;individuals with autism spectrum disorder;Inequity;innovation;Intellectual functioning disability;interest;International;intersectionality;Lived experience;Manuscripts;marginalization;member;Mental Health;Methods;minority investigator;Minority-Serving Institution;novel;Photography;Primary Care;primary care provider;Procedures;Production;Provider;Psychiatric Hospitals;Publishing Peer Reviews;racial identity;racial population;recruit;Research;Research Domain Criteria;research in practice;Research Personnel;Research Priority;research to practice;Resources;Role;Rural;Sampling;Scholarship;Science;Scientist;Secondary Schools;Series;Services;sex;social;social media;Speed;Students;success;suicidal risk;symposium;Training;Training Activity;Translational Research;Twitter;undergraduate student;Universities;Visit;Vocational rehabilitation;Voice;web site;Work;Writing


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Bioengineering;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Precision Medicine;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Asthma, a chronic lung disease that affects 20 million American adults, has well-known disparities in prevalence, severity and death by race/ethnicity, socioeconomic status and sex. We will use Electronic Health Record (EHR) data enhanced with information on social, economic, and environmental characteristics to identify sub-groups of adults with asthma who share common patterns of risk factors. This information will be used to create a tool that can support precision patient care strategies, as well as motivate public health strategies to decrease asthma risk in specific geographic areas.

PI_NAMEs: HUBBARD, REBECCA ;WEISSMAN, GARY  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: Accounting;Address;Adult;Adult asthma;Affect;Air Pollution;airway hyperresponsiveness;airway obstruction;Algorithms;American;Area;Asthma;asthma exacerbation;asthmatic patient;Black race;Caring;Cessation of life;Characteristics;Child;Chronic Disease;Chronic lung disease;Clinical;clinical decision support;clinically significant;Community Surveys;Complex;cost;COVID-19 pandemic;Data;Data Element;data integration;Data Sources;design;Disparity;Economic Factors;Economics;electronic health information;Electronic Health Record;Emergency Situation;Environmental Exposure;Environmental Risk Factor;Ethnic Origin;Geographic Distribution;Geographic Locations;Goals;Health system;high risk;Hypersensitivity;improved;Income;Individual;individual patient;Insurance Coverage;Intervention;Life;Link;Manuals;Measurement;Medicine;Methods;Modeling;Morbidity - disease rate;Natural Language Processing;novel;Occupational;Occupations;Outcome;Outpatients;pandemic impact;Patient Care;Patients;Pattern;personalized approach;personalized care;Persons;Phenotype;point of care;Population;population health;post-pandemic;pre-pandemic;Prevalence;prototype;Public Health;Race;Records;Risk;Risk Factors;Severities;sex;social;social factors;social health determinants;Socioeconomic Status;software development;Source;Stimulus;Subgroup;support tools;Surveys;Symptoms;Techniques;Telephone;therapy design;Time;tool;United States Environmental Protection Agency;Visit;Vulnerable Populations;Woman

PROJECT_TITLE: Precision Approaches to Reduce Asthma Disparities with Electronic Health Record Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(02)]


NIH_SPENDING_CATS: Aging;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Social Determinants of Health;Suicide

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PI_NAMEs: HANDEN, BENJAMIN L (contact)

PROJECT_TERMS: Adherence;Adult;adult with autism spectrum disorder;Adverse event;Age;age related;aging biomarker;Algorithms;Anxiety;Appointment;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic;Biological Markers;Brain;Clinical;Clinical Data;cognitive testing;cohort;Collaborations;Communication;Communities;Consent;Crisis Intervention;Data;Diagnosis;Diagnostic;Differential Diagnosis;Dimensions;Documentation;Electronic Mail;Enrollment;Ensure;ethnic identity;Ethnic Origin;experience;Feeling suicidal;Female;Funding;Funding Mechanisms;Goals;Grant;Health Personnel;human old age (65+);inclusion criteria;indexing;Individual;innovation;Intellectual functioning disability;Lead;Machine Learning;marginalization;marginalized population;Measures;meetings;Mental Depression;Mental Health;Methods;Minority;Monitor;Newsletter;novel;older adult;Participant;participant retention;Personality Disorders;Persons;Phenotype;phenotypic data;predictive modeling;Probability;Procedures;Process;Productivity;programs;Protocols documentation;Psychiatric Diagnosis;Race;racial identity;Recording of previous events;recruit;Recruitment Activity;Registries;Reporting;Research;Research Domain Criteria;Research Personnel;Research Project Grants;Resources;response;Risk;Rural;Safety;satisfaction;Schedule;screening;service intervention;Services;sex;Structure;success;suicidal;suicidal behavior;suicidal risk;Suicide;Symptoms;System;theories;Time;tool;Training;Uncertainty;United States National Institutes of Health;Update;Visit


NIH_SPENDING_CATS: Bioengineering;Networking and Information Technology R&D (NITRD)

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE  We  are  creating  user- friendly  and  targeted  tools  to  create  hypothesis- driven  models  of  entire  cells  that  integrate  the  large  body  of  available  knowledge  on  cellular  composition  and  biomolecular  structure.  In  collaboration with experimental and computational biologists, we are applying these methods to systems of  biomedical  interest,  with  a  focus  on  the  interpretation  of  tomographic  data  and  modeling  and  simulation  of  bacterial and mitochondrial genomes. Integrative structural biology also provides unparalleled opportunities  for outreach and education by providing a comprehensive and intuitive understanding of living systems that  spans from atoms to cells.

PI_NAMEs: AUTIN, LUDOVIC  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 3-Dimensional;Actins;Address;Articulation;Automobile Driving;Bacterial Genome;Bacterial Model;Biological;biological systems;Cell model;Cells;Collaborations;Communities;Complex;Computational Biology;computer infrastructure;Computer software;Data;data integration;Data Set;Databases;Dendritic Spines;Development;Education and Outreach;Electrons;experience;Generations;Genome;Glass;Goals;Heterogeneity;Image;in silico;interest;Intuition;Knowledge;Laboratories;method development;Methods;Mitochondria;mitochondrial genome;model building;Modeling;models and simulation;Molecular;Molecular Structure;Mycoplasma;novel;Organelles;Organism;Property;Proteins;Proteomics;prototype;Research Personnel;Resolution;Roentgen Rays;simulation;structural biology;Structural Models;Structure;Structure of beta Cell of islet;System;Technology;Testing;three-dimensional modeling;Time;Tomogram;tomography;tool;usability;user-friendly;Validation;Visualization;Work

PROJECT_TITLE: Modeling and Interacting with the Visible Molecular Cell

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Suicide

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Advocacy;Age;Ally;autism spectrum disorder;autism symptoms;autistic;Brain;burnout;Calibration;Categories;Clinical;cognitive interview;cognitive system;Comprehension;Data;demographics;design;Development;Diagnosis;Dimensions;Ensure;Equipment and supply inventories;Factor Analysis;Feeling suicidal;General Population;Generations;Goals;Growth;Hour;human old age (65+);improved;indexing;Individual;individuals with autism spectrum disorder;Information Systems;Life;machine learning model;Measures;Mental Health;Modeling;Negative Valence;Outcome Measure;Participant;Patient Outcomes Assessments;Patient Self-Report;Positive Valence;Probability;Process;prospective;Psychometrics;psychosocial;Quality of life;Questionnaires;random forest;Reporting;Research;Research Domain Criteria;response;Risk;Risk Factors;Safety;Sampling;screening;Sensory;sex;Social Processes;sound;Subgroup;suicidal;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;suicide rate;Symptoms;System;Testing;theories;therapy development;Time;Training;United States National Institutes of Health;Work

PROJECT_TITLE: Mental Health in Autistic Adults:  And RDoC Approach


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Suicide;Violence Research

PI_NAMEs: BYLSMA, LAUREN M (contact)

PROJECT_TERMS: Acute;Address;Adult;adult with autism spectrum disorder;Affect;Aggressive behavior;Ambulatory Monitoring;Anger;Arousal;Autism Diagnosis;autism spectrum disorder;autistic;Behavior;Buffers;Chronic;Clinical;clinical phenotype;clinically significant;cohort;Communities;Complement;Complex;Data;design;Detection;Development;Dimensions;dysphoria;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional behavior;emotional experience;Emotions;Event;Feeling suicidal;flexibility;functional outcomes;graph theory;Hour;human old age (65+);Impairment;Impulsivity;Individual;Individual Differences;individuals with autism spectrum disorder;innovation;Intervention;Life;Link;Literature;Mental Health;Modeling;Motivation;multimodality;negative affect;Negative Valence;neural;neuroimaging;non-suicidal self injury;novel;older adult;Outcome;Parasympathetic Nervous System;Patient Self-Report;Pattern;Physiological;Physiology;Positive Valence;Process;Protocols documentation;Psychophysiology;Recording of previous events;Recovery;Regulation;Reporting;Research;Research Domain Criteria;resilience;respiratory;response;Risk;Sample Size;Sampling;Self-Injurious Behavior;Sensory;Severities;Sinus Arrhythmia;social;Subgroup;suicidal;suicidal behavior;suicidal risk;Sympathetic Nervous System;System;Time;verbal;Work


NIH_SPENDING_CATS: Anxiety Disorders;Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Suicide

PI_NAMEs: SIEGLE, GREG J (contact)

PROJECT_TERMS: Adult;adult with autism spectrum disorder;Affective;Age;autism spectrum disorder;autistic;Behavioral;behavioral response;Brain;causal model;Cognitive;cognitive control;cognitive task;Communities;coping;Data;design;Differential Equation;Distal;Distress;Ecological momentary assessment;emotion dysregulation;emotion regulation;Emotional;emotional stimulus;Emotions;Ethnic Origin;Evaluation;Event;experience;Feedback;Feeling suicidal;Formulation;Functional Magnetic Resonance Imaging;Generations;Hearing;Image;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;Intervention;Life;Literature;Measures;Mental Depression;Mental Health;Modeling;Motor;Names;neural;neural model;Neural Network Simulation;neural recruitment;neuroimaging;neuromechanism;Outcome;Patient Self-Report;Perception;Physiological;Post-Traumatic Stress Disorders;preservation;Process;prospective;Psychopathology;Psychophysiology;Pupil;Reaction;Recording of previous events;recruit;Regulation;Research Domain Criteria;respiratory;response;Rest;Self-Injurious Behavior;Semantics;Sensory;Series;sex;Sexual and Gender Minorities;sexual minority status;Sinus Arrhythmia;social;Social Network;Stimulus;success;suicidal;suicidal risk;Suicide;support network;System;Testing;Time;Trauma;Visual;Work


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: GAINESVILLE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Odors are powerful drivers of emotional responses, and aberrant assignment of emotions to odors underlies a variety of human neuropsychiatric conditions. The results of this project will enhance our understanding of how odors acquire emotional significance, and will expand our knowledge of the brain regions and neurotransmitter systems involved. This proposal therefore supports the NIH and NIDCD’s mission to understand how odors are processed in the brain to support perception and ultimately behavior.

PI_NAMEs: SNIFFEN, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Ablation;Affect;Affective;Amygdaloid structure;Behavior;Behavioral;behavioral response;Binding;Brain;Brain region;Chemosensitization;Computing Methodologies;conditioned fear;Cues;Desire for food;Disease;Dopamine;Dopamine Antagonists;Dopamine Receptor;Electrophysiology (science);Emotional;Emotions;experimental study;Flupenthixol;Food;Fright;gain of function;Gene Expression;hedonic;hippocampal pyramidal neuron;Human;Hunger;Immediate-Early Genes;in vivo;Infusion procedures;insight;Intervention;Knowledge;learned behavior;Learning;Light;loss of function;Memory;Methods;Mission;Mood Disorders;multisensory;Mus;National Institute on Deafness and Other Communication Disorders;National Research Service Awards;nerve supply;neural;neural circuit;neuronal excitability;Neurons;neuropsychiatry;Neurotransmitters;Odors;optogenetics;Outcome;Perception;Pharmacology;postsynaptic;Process;Punishment;Quinine;Regulation;response;Rewards;Role;Sensory;Shock;Site;Slice;Socialization;Stimulus;Sucrose;Synaptic Potentials;System;Testing;Training;United States National Institutes of Health;Ventral Tegmental Area;Work

PROJECT_TITLE: Basolateral amygdala support of odor valence learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-K (12)]


ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Supracellular actomyosin networks are used to fold a diverse range of tissues during development, like neural tube closure. Errors during neural tube closure cause congenital malformations in humans, but we lack a complete understanding on how actomyosin networks contribute to neural tube closure. We propose test a mechanistic model of mammalian neural tube closure which will provide insight on the generalizability of actomyosin-mediated folding mechanisms and create a conceptual foundation from which to understand, prevent, and treat congenital malformations.

PI_NAMEs: DELAO, JUANA  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: 3-Dimensional;Ablation;Actomyosin;Address;Adherens Junction;Apical;Biology;career;Cell Shape;Cells;Cellular biology;Cellular Morphology;Cephalic;college;comparative;Congenital Abnormality;constriction;Coupled;Cytoskeletal Proteins;Data;Data Set;design;Development;Embryo;Embryonic Development;Event;Evolution;experimental study;F-Actin;Failure;Filament;Foundations;Generations;Human;Image;imaging platform;information gathering;insight;Lasers;Lateral;Lead;Location;London;Measurement;Measures;Mechanics;Mediating;Modeling;Motor;Mus;Mutant Strains Mice;Myosin ATPase;Nature;Neural Fold;Neural tube;Neural Tube Closure;neuromechanism;Organism;Pathology;Pathway Analysis;Phase;prevent;Preventive therapy;Preventive treatment;Property;Proteins;reconstruction;Resolution;response;Role;Sampling;Shapes;Somites;Structure;System;Testing;theories;Time;Tissue Microarray;Tissues;Training;two-dimensional;Universities;Variant;Vertebrates;Wild Type Mouse;Work

PROJECT_TITLE: Quantifying the contribution of supracellular actomyosin networks during mouse neural tube closure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Although death is a common occurrence, remarkably little work has examined how animals are able to sense and respond to the dead. This proposal seeks to characterize how the fruit fly, Drosophila, senses and responds to the dead of its own kind (conspecifics), as well as the mechanisms underlying this response. Ultimately, our work may have implications for human health, as the spread of vector-borne disease relies on a careful balance between insect life and death.

PI_NAMEs: SIFF, EMILY JESSICA (contact)

PROJECT_TERMS: Acetates;Address;Adult;Adult women;Animals;Behavior;Biological Assay;Cannibalism;Cessation of life;climate change;Cues;Culicidae;Curiosities;Detection;Disease;Drosophila genus;egg;Electrophysiology (science);Equilibrium;Exposure to;Female;fly;Food;food quality;Foundations;Gene Modified;Genetic;Goals;Health;Human;human old age (65+);Hydrocarbons;innovation;Insecta;Laboratories;Life;Machine Learning;Mass Fragmentography;Mathematics;Mediating;Methods;mutant;Neurons;Nutrient;Nutritional;Odors;Order Coleoptera;Organ;Organism;Oviposition;Partner in relationship;Pheromone;Play;Positioning Attribute;Positive Valence;Predatory Behavior;preference;receptor;Research;Resources;response;Role;Sensory;sensory system;Side;Smell Perception;Source;Spectrum Analysis;statistics;System;Techniques;Technology;Testing;Time;tool;Vector-transmitted infectious disease;Work

PROJECT_TITLE: Drosophila Chemosensory Responses to Dead Conspecifics