NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Project Narrative About 40% of the human genome consists of viral DNA sequences derived from ancient retroviruses, and functions of these retroviral sequences in vascular dementia are not well understood. The TREX1 protein regulates these retroelements in our genome, and patients with inherited mutations in TREX1 develop retinal vasculopathy with cerebral leukoencephalopathy (RVCL), a vascular dementia that causes disability and premature death in 100% of affected individuals. We propose to determine how TREX1 mutants regulate genomic DNA and retroelements to cause this devastating, inherited small vessel disease of the brain.

PI_NAMEs: MINER, JONATHAN J (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Adult;Affect;Age;age related;Aging;Animal Model;Autoantibodies;Autoimmunity;Automobile Driving;autosome;B-Lymphocytes;Blindness;Blood Vessels;Brain Diseases;C-terminal;care coordination;Cause of Death;Cell Aging;Cell Death;Cell model;Cell Nucleus;cell type;Cells;cerebral atrophy;Cerebral small vessel disease;Cerebrum;Cessation of life;chromatin remodeling;Chromatin Structure;Chronic;Cytosol;Dementia;Deoxyribonucleases;disability;Disease;DNA;DNA Damage;DNA Repair;DNA Sequence;effective therapy;Endogenous Retroviruses;Endoplasmic Reticulum;enzyme activity;Enzymes;Euchromatin;Failure;Family;Frameshift Mutation;Genome;Genomic DNA;Goals;Heterochromatin;Heterozygote;Human;human disease;Human Genome;Humoral Immunities;Immune;Immunosuppression;Individual;Inherited;inhibitor;innovation;insight;Interferons;Knock-out;Laboratories;Lead;Lesion;Leukoencephalopathy;Mammalian Cell;mammalian genome;Mediating;Medicine;Michigan;Microvascular Dysfunction;Modeling;Molecular;mouse model;Mus;mutant;Mutant Strains Mice;Mutation;novel;novel therapeutics;Onset of illness;Organ;Pathogenesis;Pathology;Pathway interactions;Patients;Penetrance;Pennsylvania;Phenotype;Poly(ADP-ribose) Polymerase Inhibitor;Population;Predisposition;premature;Premature aging syndrome;prevent;pro-aging;Production;Proteins;Refractory;Research;Research Personnel;response;restraint;Retina;Retroelements;Retroviridae;Role;Sampling;senescence;Serology;single-cell RNA sequencing;Stimulator of Interferon Genes;Testing;Transgenic Mice;TREX1 gene;TREX1 protein;United States;Universities;Vascular Dementia;Vascular Diseases;Viral;viral DNA;white matter;Work

PROJECT_TITLE: Role of TREX1 in age-related hereditary leukoencephalopathy

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ADMINISTERING_IC: GM

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: TALLAHASSEE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Project Narrative Cryogenic electron microscopy has transformed the field of structural biology in the last few years. Despite the tremendous progress in determining structures by cryo-EM, substantial challenges remain in data processing and specimen preparation for proteins that form tubular arrays. New tools will be developed that facilitate structure determination of medically relevant tubular samples such as Drp1, dynamin, and Opa1, as well as other samples that prove resistant to cryogenic preparation.

PI_NAMEs: STAGG, SCOTT M (contact)

PROGRAM_OFFICER_NAME: FLICKER, PAULA F

PROJECT_TITLE: Tools for Enabling Challenging Structure Determination by Cryo-EM

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Biotechnology;Genetics;Human Genome;Mental Health;Neurosciences;Pediatric

ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PI_NAMEs: GRUEN, JEFFREY R (contact)

PROJECT_TERMS: Achievement;Anxiety;Architecture;Attention;Behavioral;Biologic Characteristic;Biological;Brain;Brain imaging;Brain region;brain tissue;Categories;Chromatin Loop;Classification;Clinical;clinical diagnostics;clinically relevant;Collaborations;comorbidity;Comprehension;connectome;Data;Data Analyses;Data Set;Diagnostic;Differential Diagnosis;Disease;disease classification;Epigenetic Process;epigenome;Equation;Factor Analysis;functional genomics;Functional Magnetic Resonance Imaging;Gene Expression;Genes;Genetic;genetic architecture;Genetic Diseases;Genetic Drift;Genetic Research;Genetic Risk;genetic variant;Genetic Variation;genome wide association study;genome-wide;Genomics;Goals;Grouping;Growth;Heterogeneity;High Prevalence;Image;improved;indexing;Individual;Knowledge;Learning Disabilities;Learning Disorders;Letters;Linkage Disequilibrium;longitudinal analysis;Methods;Methylation;Modeling;Molecular Genetics;Nature;neurogenesis;Neurons;open source;Organoids;Pathway interactions;Persons;Phenotype;pleiotropism;polygenic risk score;Process;Property;Reading;Regulatory Pathway;Risk Factors;risk sharing;Sampling;skills;sound;statistics;success;System;Testing;Time;trait;Transcend;transcriptome;Variant;Vocabulary

PROJECT_TITLE: Shared genetic architecture of specific learning disorders at behavioral, functional genomic and molecular genetic levels of analysis


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Disability Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Social Determinants of Health

PI_NAMEs: WILLCUTT, ERIK G (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Agreement;Anxiety;anxiety management;anxiety symptoms;anxiety treatment;Area;Caregivers;Child;childhood anxiety;Clinic;clinical anxiety;Collaborations;Communities;community engaged research;comorbidity;Data;design;Diagnosis;Differential Diagnosis;Disability Evaluation;Disease;education access;Educational Intervention;Effectiveness;efficacy evaluation;Eligibility Determination;Enrollment;Equity;Ethnic Origin;Evaluation;evidence base;Evidence based intervention;experience;Family;feasibility testing;Feedback;Financial Support;Focus Groups;follow-up;functional outcomes;Goals;group intervention;health care disparity;Health Services Accessibility;high reward;high risk;implementation barriers;implementation evaluation;improved;Income;Individual;Individual Differences;interest;Intervention;Interview;Knowledge;Learning Disabilities;Literature;low socioeconomic status;Mathematics;Measures;Mental Health;Methods;Neuropsychology;novel;Outcome;Parents;prevent;Procedures;Process;Process Assessment;psychoeducation;Qualitative Methods;Questionnaires;Race;Random Allocation;Reading;Recommendation;Reporting;Research;Research Personnel;response;satisfaction;Science;Services;socioeconomics;Suggestion;Surveys;Testing;Time;treatment as usual;Underrepresented Populations;Work;Youth

PROJECT_TITLE: Evaluating the community impact of neuropsychological services and a pilot group-based treatment for anxiety in children with learning disabilities


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

ORG_STATE: CA

PHR: Project Narrative. Despite the potential toxicity of liquid nicotine, there is currently no treatment for acute nicotine poisoning. A first-in-class enzyme therapeutic for acute nicotine toxicity is proposed. The enzyme will sequester nicotine and catabolize it to a non-toxic component, thereby reducing its effective concentration at sites of action, the nicotinic-type acetylcholine (cholinergic) receptors (nAChRs), which in turn is anticipated to alter the nicotine’s toxic effects.

PI_NAMEs: JANDA, KIM  (contact)

PROGRAM_OFFICER_NAME: VEMURI, KIRAN R V

PROJECT_TERMS: 5 year old;Accident and Emergency department;Accidents;Acetylcholine;Activated Charcoal;Acute;Address;Adrenergic Antagonists;Adult;Affinity;Agonist;Animal Model;Antibodies;Antidotes;aspirate;Attenuated;Autonomic ganglion;Benzodiazepines;Binding;Biodistribution;Biological;Biological Assay;Blood;Blood Pressure;Bradycardia;Brain;Brain region;Buffers;Candy;Carbon;cardiovascular collapse;Cessation of life;Child;Childhood;cholinergic;Cholinergic Receptors;Chronic;Clinical Research;Clinical Trials;Coma;combustible cigarette;Complex;Consumption;Directed Molecular Evolution;Dose;Drug Kinetics;Dyspnea;efficacy evaluation;Electronic cigarette;electronic cigarette use;electronic liquid;Engineering;Enzymes;Evolution;experimental study;Exposure to;Failure;Fatal Outcome;Fruit;Gastric Lavage;Gene Library;Generations;Genes;Genetic Recombination;Goals;Half-Life;Hand;Heart Rate;Hour;Hypotension;Immunologics;improved;In Situ;Information Systems;Ingestion;Intervention;Libraries;liquid nicotine;Marketing;Measures;Mechanical ventilation;Menthol;Metabolism;Modeling;Monoclonal Antibodies;mouse model;Muscle;Mutagenesis;mutant;nerve agent;neural;Neuromuscular Junction;Neurons;Nicotine;nicotine cessation;nicotine exposure;nicotine oxidase;nicotine use;nicotine vaccine;Nicotinic Receptors;Nitrogen;Oral Ingestion;organophosphate poisoning;Overdose;Oxidoreductase;Patients;Peripheral;Pharmaceutical Preparations;Pharmacodynamics;pharmacologic;placebo group;Plethysmography;Poison;Poisoning;Population;Positioning Attribute;pre-clinical;Pseudomonas putida;Publishing;receptor;Reporting;respiratory;Respiratory Failure;response;Risk;Rodent;Rodent Model;Sales;Seizures;Serum;Signs and Symptoms;Site;smoking abstinence;smoking cessation;Societies;Source;Structure;Supportive care;System;Therapeutic;therapeutic enzyme;thermostability;Tobacco;tobacco products;Toxic effect;Treatment Protocols;Uncertainty;Vaccines;Variant;Vulnerable Populations

PROJECT_TITLE: An Enzyme-Based Antidote for Acute Nicotine Toxicity

STUDY_SECTION: DBDT

STUDY_SECTION_NAME: Drug and Biologic Disposition and Toxicity Study Section[DBDT]


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Rehabilitation

ORG_CITY: Broomfield

ORG_NAME: POINT DESIGNS, LLC

PHR: PROJECT NARRATIVE Approximately 45,000 people sustain partial hand amputations in the United States every year, and amputation of full fingers can cause physical, psychosocial, and economic damage to an individual. There is currently only one powered prosthetic finger available to people with partial hand amputations in the United States, and fragility of these devices is often reported. In this project, Point Designs proposes to develop and commercialize a robust, powered prosthetic finger utilizing an electromechanical design that appropriates anatomy, produces user- defined forces and speeds, and withstands the rigors of everyday life.

PI_NAMEs: SLIKER, LEVIN  (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Address;Algorithms;Amputation;Anatomy;battery life;Biological Sciences;Biomedical Technology;Budgets;Cells;Characteristics;Charge;Clinical;commercialization;Complex;cost;design;Development;Devices;Digit structure;Economics;Employment;Engineering;Ensure;experience;Family;Fingers;Focus Groups;Funding;Goals;grasp;Hand;Hand functions;Health;health care settings;improved;Individual;innovation;Lead;Life;Light;limb loss;Lithium;manufacture;Measures;Medical Technology;miniaturized device;Mission;Motor;Myoelectric prosthesis;National Institute of Biomedical Imaging and Bioengineering;novel;patient population;Patients;Persons;Phase;physical science;Polymers;powered prosthesis;Prosthesis;prosthetic hand;prototype;psychosocial;Reporting;research and development;Resources;Series;Speed;Strategic Planning;System;technological innovation;Technology;Testing;Torque;transmission process;United States;Upper Extremity;Vision;voltage;Work

PROJECT_TITLE: The Point Powered: A Robust Actuated Prosthetic Finger for Partial Hand Amputation


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Overall The underserved vulnerable African American, Asian-Pacific American and Hispanic American populations in the PA-NJ-NYC region experience significant cancer-related health disparities across the cancer continuum, from a higher prevalence of cancer risk factors to delayed screening and diagnoses, experiencing more advanced disease, and poorer outcomes. SPEECH has made significant strides toward transforming cancer health disparities research and education; research infrastructure and platforms that enabled investigators to advance cancer health equity in these underrepresented and underserved populations. In the next five years, our Partnership aims to advance cancer health disparities research, training/workforce development, and community-informed interventions by breaking structural, systemic barriers and promoting inclusive excellence across disciplines among basic, clinical and population science researchers, trainees and diverse underserved communities

PI_NAMEs: ERBLICH, JOEL ;FORD, JENNIFER S;MA, GRACE X. (contact);RAGIN, CAMILLE C.

PROGRAM_OFFICER_NAME: SAN MIGUEL-MAJORS, SANDRA L

PROJECT_TERMS: Acceleration;Address;advanced disease;Advanced Malignant Neoplasm;African American;anti-cancer research;Area;Asian Americans;Asian Pacific American;aspirate;Basic Science;bench to bedside;Bioinformatics;Biometry;Black race;cancer education;cancer health disparity;Cancer health equity;Cancer Intervention;cancer prevention;cancer risk;career development;Career Mobility;Clinical Sciences;Collaborations;college;Communities;community based participatory research;community engaged approach;community engaged intervention;community engagement;Community Health Aides;community organizations;Community Outreach;Competence;Comprehensive Cancer Center;County;COVID-19 pandemic;Data;Death Rate;Diagnosis;Discipline;Doctor of Philosophy;Education;education research;Equity;ethnic minority;Evaluation;evidence base;experience;Faculty;Feedback;Fostering;Foundations;Fox Chase Cancer Center;Funding;Grant;Health;Health Disparities Research;Health equity research;High Prevalence;Hispanic Americans;Hispanic-serving Institution;improved;Individual;Infrastructure;innovation;Institution;Interdisciplinary Study;Malignant Neoplasms;member;Mentors;Mentorship;Methods;Minority;Modeling;Monitor;mortality;multidisciplinary;Needs Assessment;Neighborhoods;next generation;Outcome;outreach;outreach program;Pilot Projects;Population;Population Sciences;Positioning Attribute;Poverty;programs;Publications;racial minority;Recommendation;recruit;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Support;Resources;Risk Factors;Schools;Science;Scientist;screening;skills;social determinants;Societies;Strategic Planning;structural determinants;Students;success;systemic barrier;Target Populations;Training;translational approach;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Underserved Population;Universities;Vision;Workforce Development

PROJECT_TITLE: (1/2) TUFCCC/HC Regional Comprehensive Cancer Health Disparities Partnership


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MA, GRACE X. (contact)

PROJECT_TERMS: Accountability;Address;Advanced Malignant Neoplasm;Advisory Committees;African;African American;American;anti-cancer research;Asian;Asian Pacific American;Black race;cancer health disparity;cancer prevention;Cancer Research Project;career;Collaborations;college;Communication;Communities;community advisory board;community organizations;Community Outreach;Decision Making;design;Doctor of Philosophy;Education;Education and Outreach;Ensure;Equity;equity, diversity, and inclusion;ethnic minority population;Evaluation;experience;Faculty;Fostering;Foundations;Fox Chase Cancer Center;Goals;Grant;Health Disparities Research;Health Sciences;Health system;Hispanic Americans;implementation outcomes;improved;Infrastructure;Institution;inter-institutional;Joints;Latinx;Leadership;Letters;Localized Malignant Neoplasm;medical schools;meetings;member;Mentors;Mission;multidisciplinary;New Jersey;New York City;operation;Organization administrative structures;organizational structure;Outcome Measure;Performance;Philadelphia;population health;Productivity;programs;racial minority population;Regional Cancer;Research;Research Infrastructure;Research Personnel;Research Priority;Research Project Grants;Resource Sharing;Science;Services;Structure;systemic barrier;Underserved Population;Universities;Vision;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Data Science;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: ROSS, ERIC ANDREW (contact)

PROJECT_TERMS: Acceleration;Address;Advanced Malignant Neoplasm;African;Algorithms;American;Applications Grants;Artificial Intelligence;artificial intelligence algorithm;Asian;Bioinformatics;biological systems;Biometry;Biostatistics Core;Cancer Biology;cancer genetics;cancer health disparity;cancer prevention;career;Cell division;ChIP-seq;Clinical;clinical application;Clinical Informatics;Clinical Trials;Collaborations;Collection;Communities;computer infrastructure;Consultations;cost effective;Data;Data Analyses;Data Protection;data resource;Data Set;Database Management Systems;Development;Diverse Workforce;DNA sequencing;Doctor of Philosophy;Education;Environment;Epigenetic Process;epigenomics;Equity;ethnic minority population;experience;Experimental Designs;Fostering;Funding;Future;Genetic;Genomics;Goals;Grant;graph neural network;Health Disparities Research;High Performance Computing;Informatics;Infrastructure;innovation;Institution;instrument;interest;Investigation;Knowledge Extraction;Laboratories;Latinx;Leadership;Link;Machine Learning;Malignant Neoplasms;Manuscripts;Medical Genetics;member;Methods;minority investigator;minority trainee;Mission;Molecular;Multiomic Data;New Jersey;New York City;novel;Phase;Philadelphia;Pilot Projects;Play;Population Sciences;preclinical study;Productivity;protein function;protein protein interaction;Proteins;Proteomics;Publishing;Qualitative Research;racial minority population;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;Research Proposals;Research Support;Research Training;Resource Sharing;Retrieval;Ribosomal RNA;Role;Science;Secure;Services;single-cell RNA sequencing;skills;software development;statistics;Students;Surface;System;systemic barrier;Technology;tool;Training;transcriptome sequencing;Underrepresented Minority;Writing

PROJECT_TITLE: Biostatistics and Bioinformatics Core (BBC)


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BALTIMORE

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: NARRATIVES Recognition of barriers of oral health inequities and disparities is critical. Current project will establish an educational and collaborative platform for inter-institutional practice-based research networks across two dental schools in the University of Maryland Baltimore and the Howard University to study the associations of racial bias with provision of dental care.

PI_NAMEs: OATES, THOMAS W (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Address;Adherence;Affect;Awareness;Baltimore;Black Populations;Black race;care delivery;care outcomes;Caring;Client satisfaction;Clinical;clinical care;clinical practice;Clinical Research;clinical training;Cognitive;cohort;Collaborations;Communities;Data;Dental;Dental Care;Dental Education;Dental Schools;Dental Students;Development;disparity reduction;District of Columbia;Education;education pathway;educational atmosphere;Elements;Environment;Equitable healthcare;Equity;experience;explicit bias;Faculty;Fostering;Future;Goals;health care disparity;health disparity;health equity;health inequalities;Hypertension;implementation science;improved;Inequity;Institution;inter-institutional;Lead;Maryland;Mentors;next generation;Oral health;Outcome;Patient Care;patient population;patient-clinician communication;Patients;Population;Practice based research;practice-based research network;programs;Provider;Race;racial bias;racial prejudice;Recommendation;Reporting;Research;Research Activity;Research Project Grants;research study;Research Training;Role;Schools;Scientific Inquiry;Scientist;screening;skill acquisition;Stereotyping;Students;synergism;Training;Universities

PROJECT_TITLE: Examining provider bias in an underserved dental patient population: Improving health equity through a Dental School Practice-based Research Network (dsPBRN)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Mental Health;Pediatric

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PHR: Autism contains a puzzling conundrum: Although 70% of autistic individuals demonstrate age-appropriate language and cognitive abilities on standardized tests, they nonetheless experience significant communication breakdowns during everyday interactions that negatively affect their social, educational, and occupational outcomes. This proposal advances research and clinical practice by defining clinically meaningful markers of conversational success in 560 autistic and neurotypical adolescents participating in (1) neurotype-concordant (autistic-autistic or neurotypical-neurotypical) and (2) neurotype-discordant (autistic-neurotypical) dyads. By combining traditional standardized language tests with innovative psycholinguistic measures derived from spontaneous natural conversations, a key output of this project will be clinically useful and ecologically valid profiles of communication strengths and weaknesses that can be used to inform personalized interventions focused on improving autistic adolescents’ conversational success.

PI_NAMEs: EIGSTI, INGE-MARIE  (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 15 year old;Acoustics;Address;Adherence;Administrator;Adolescent;adolescent with autism spectrum disorder;Affect;Age;aged;autism spectrum disorder;autistic;Back;Biological Markers;Boredom;Categories;Clinical;clinical practice;cognitive ability;Collaborations;Communication;Communication difficulty;complex data;Computer Models;Data;Data Set;data standards;Development;Diagnostic;Dimensions;Divorce;dyadic interaction;Education;Empathy;experience;Failure;Frequencies;Funding;girls;Goals;Grain;Head;improved;Individual;individuals with autism spectrum disorder;Influentials;innovation;interest;Intervention;Label;Language;Language Tests;lens;lexical;Life;Linguistics;Link;Lived experience;Machine Learning;Measures;Methodology;Modeling;National Institute on Deafness and Other Communication Disorders;Natural Language Processing;network models;novel;Occupational;Outcome;Output;Participant;personalized intervention;Persons;phonology;Process;Psycholinguistics;repaired;Reporting;Research;response;Response Latencies;Sampling;satisfaction;scaffold;Semantics;social;Social Environment;Social Interaction;social metrics;Speech;Speed;Standardization;standardize measure;stem;Strategic Planning;Structure;Subgroup;success;syntax;Teenagers;Testing;theories;tool;Transcend;verbal;Videoconferencing;Visual;Visualization

PROJECT_TITLE: Ready to CONNECT: Conversation and Language in Autistic Teens

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


NIH_SPENDING_CATS: Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

PI_NAMEs: BASS, SARAH B (contact)

PROJECT_TERMS: 3-Dimensional;Acculturation;Address;Affect;African American;American Society of Clinical Oncology;arm;Bass;Biostatistics Core;Black race;Cancer Center;cancer health disparity;Cancer Patient;cancer risk;cancer therapy;Cervical;Communication;Communities;Community Outreach;Comparison arm;Conflict (Psychology);Country;cultural values;Data;Decision Aid;Decision Making;Devices;Dimensions;Doctor of Philosophy;education research;Educational Materials;Effectiveness;efficacy evaluation;efficacy testing;eHealth;ethnic diversity;Family;Funding;Gallbladder;Gender;Genes;Genetic;Genetic Counseling;genetic information;Genetic Risk;Genetic study;genetic testing;genomic profiling;Genomics;Germ Lines;Goals;Grant;Health;Health behavior change;health equity;Health Promotion;hereditary risk;High-Risk Cancer;Hispanic Americans;improved;Information Management;innovation;Intervention;intervention participants;Knowledge;Language;Latinx;Latinx population;Link;Liver;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Maps;Marketing;Medical;Medical Genetics;Methods;Modeling;mortality;Mutation;New York City;Not Hispanic or Latino;Oncologist;Oncology;Patient Preferences;Patient Recruitments;Patients;Perception;Philadelphia;Policies;Population;Population Heterogeneity;precision oncology;preference;primary outcome;Provider;provider communication;Public Health;racial diversity;randomized trial;Readiness;recruit;Reporting;Research Personnel;Research Project Grants;Risk;Risk Assessment;secondary outcome;Site;Spanish;Stomach;support tools;systemic barrier;Tablets;Test Result;Testing;tool;treatment arm;tumor;Underserved Population;vector;Vision;Work;Writing

PROJECT_TITLE: Full Research Project 1: Testing the Efficacy of an eHealth Decision Support Tool to Help Latinx Cancer Patients Make Informed Decisions About Tumor Genomic Testing


ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PUBLIC HEALTH RELEVANCE Nigeria has a substantial burden of cancer that could be prevented through enhancing vaccination services. C3-RISE is a comprehensive implementation science partnership between the Nigerian Institute of Medical Research, Saint Louis University, and the University of North Carolina at Chapel Hill that open new horizons in equitable cancer control and builds sustainable capacity for high-quality implementation science to control cancer using vaccines. This project will increase equity, expand uptake and sustainment of evidence-based vaccination services, and develop a pipeline of Nigerian implementation science researchers for continued success.

PI_NAMEs: EZECHI, OLIVER CHUKWUJEKWU;IWELUNMOR, JULIET  (contact);TUCKER, JOSEPH DAVID

PROGRAM_OFFICER_NAME: CORREA-MENDEZ, MARGARITA

PROJECT_TERMS: Acceleration;Address;Adoption;Affect;Africa;aged;anti-cancer research;Apical;Applications Grants;apprenticeship;Attention;Award;Birth;Cancer Burden;Cancer Control;cancer prevention;Cancer Vaccines;career;Cessation of life;community based participatory research;community engagement;community setting;Consolidated Framework for Implementation Research;Country;Coupled;crowdsourcing;Decentralization;design;direct application;Dose;Educational Activities;Environment;Equity;Evaluation;evidence base;Evidence based intervention;Faculty;girls;Goals;Grant;Guidelines;Health;health equity;health inequalities;Hepatitis B;Hepatitis B Vaccination;Hepatitis B Vaccines;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;implementation evaluation;implementation facilitators;implementation outcomes;implementation science;implementation strategy;improved;Incidence;Infrastructure;innovation;Institution;Intervention;Learning;low and middle-income countries;malignant mouth neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of penis;Malignant neoplasm of vulva;Malignant Neoplasms;Malignant Vaginal Neoplasm;Medical Research;Mentors;Mentorship;Mission;Modeling;Monitor;mortality;multidisciplinary;National Institute of Mental Health;Newborn Infant;Nigeria;Nigerian;North Carolina;novel;outreach;Phase;Policies;prevent;Principal Investigator;Process;Productivity;public health relevance;Research;research and development;Research Personnel;Research Project Grants;research study;Resource-limited setting;Resources;scale up;Science;Services;skills;Students;success;symposium;System;Testing;tool;Training;Training Programs;Translations;Travel;United States National Institutes of Health;Universities;uptake;Vaccination;Vaccines;Vision

PROJECT_TITLE: US-Nigerian Cancer Control Center for Research on Implementation Science and Equity (C3-RISE)


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Prevention;Vaccine Related;Women's Health Research

PI_NAMEs: IWELUNMOR, JULIET  (contact)

PROJECT_TERMS: Acceleration;access disparities;Address;Adoption;Attention;Award;Cancer Control;Cancer Vaccines;Caring;Cervical cancer vaccine;Cessation of life;Clinical Services;Collaborations;Communication;Communities;community engagement;community involvement;Community Outreach;community partners;community setting;cost;Country;Creativeness;crowdsourcing;Development;Educational workshop;Ensure;Environment;Equity;Ethics;Evaluation;evidence base;Fostering;Foundations;Goals;Guidelines;Health;health goals;Health system;Hepatitis B Vaccines;Human Papilloma Virus Vaccine;Human Resources;implementation science;implementation strategy;improved;Incidence;Individual;Infrastructure;Intervention;Logistics;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;Medical Research;Methods;Modeling;mortality;Nigeria;Nigerian;North Carolina;novel;operation;outreach;Persons;Prevention;Process;programs;Protocols documentation;Public Health;Research;Research Institute;Research Personnel;Resource-limited setting;response;Role;Societies;success;Surveys;symposium;Teleconferences;Testing;Training;Translational Research;Travel;United States National Institutes of Health;Universities;Vaccines;Visual impairment;World Health Organization

PROJECT_TITLE: Administrative and Engagement Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;HIV/AIDS;Hepatitis;Infectious Diseases;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Liver disease is the second leading cause of non-AIDS related death in persons living with HIV (PLWH). Nonalcoholic fatty liver disease (NAFLD) is by far the leading form of chronic liver disease in the U.S., afflicting approximately 30% of adults. However, the incidence of NAFLD is even higher among PLWH with rates as high as 53% and there is a disproportionate burden of progressive fibrosis compared with HIV(-) NAFLD. The studies in this proposal will clarify the mechanistic link between HIV, NAFLD, the YAP/TAZ pathway, and fibrosis, and in so doing uncover novel targets for inhibitors of hepatic fibrosis and liver damage.

PI_NAMEs: CHUNG, RAYMOND T (contact);SALLOUM, SHADI ;SU, LISHAN

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: 3-Dimensional;Acceleration;Adult;antiretroviral therapy;Binding;Biological Assay;Cell Culture Techniques;Cell Proliferation;cell type;Cessation of life;Chronic;chronic liver disease;Coculture Techniques;Data;defined contribution;Diet;Disease;Exposure to;fibrogenesis;Fibrosis;Frequencies;Gene Expression;gene induction;Genes;genetic signature;Genetic Transcription;Hepatic;Hepatic Stellate Cell;Hepatocyte;High Prevalence;HIV;HIV Infections;Human;humanized mouse;In Vitro;in vivo;Incidence;Infiltration;Inflammatory;inhibitor;kidney fibrosis;Knockout Mice;Link;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;Macrophage;MAP Kinase Gene;Modeling;monocyte;mouse model;Mus;new therapeutic target;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;Nonesterified Fatty Acids;novel;Organ;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathology;Pathway interactions;Patients;Persons;Phenotype;PI3K/AKT;PIK3CG gene;Population;prevent;programs;Proto-Oncogene Proteins c-akt;Regimen;Reporting;Role;Signal Pathway;Signal Transduction;Site;Tissues;Transcription Coactivator;Transforming Growth Factor beta;Verteporfin;virology;Wild Type Mouse;Work

PROJECT_TITLE: YAP signaling in the pathogenesis of NAFLD in people living with HIV


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research;Immunization;Prevention;Vaccine Related

PROJECT_TERMS: Adoption;Africa;anti-cancer research;apprenticeship;Awareness;Cancer Burden;Cancer Control;Cancer Control Research;Cancer Science;cancer type;cancer vaccination;Cancer Vaccines;career;Cervical;Cessation of life;Clinical;cohort;Collaborations;Communities;community organizations;Country;Creativeness;crowdsourcing;design;E-learning;Equity;evidence base;Evidence based intervention;experience;Faculty;faculty mentor;Fostering;Funding;Geography;Goals;Grant;Health;Healthcare;Hepatitis B Vaccines;Human Papilloma Virus Vaccine;Hybrids;Immunization;implementation research;implementation science;improved;Individual;innovation;Institution;Institutionalization;Intervention;Lead;learning community;Malignant Neoplasms;Medical Research;Mentors;Mentorship;Methods;National Institute of Child Health and Human Development;next generation;Nigeria;Nigerian;peer support;Persons;Pilot Projects;population health;prevent;Primary carcinoma of the liver cells;programs;prototype;recruit;Research;Research Personnel;Research Support;research to practice;Resources;Science;Series;Services;Site;skills;social;supportive environment;Talents;Training;training opportunity;Travel;United States National Institutes of Health;Vaccines;virtual;Writing;Youth

PROJECT_TITLE: Research and Capacity Building Core


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SAPIENZA, CARMEN  (contact)

PROJECT_TERMS: Address;adenoma;Affect;African;African American;African American population;African ancestry;biobank;Biological;Biological Markers;biomarker identification;Black race;Blood specimen;Cancer Detection;Cancer Etiology;cancer health disparity;cancer risk;caucasian American;Caucasians;Cessation of life;Characteristics;college;Colon;colon cancer patients;Colon Carcinoma;Colonoscopy;Colorectal Cancer;colorectal cancer risk;colorectal cancer screening;Community Outreach;Consent;Data;Death Rate;Development;Diet;disparity elimination;disparity reduction;DNA Markers;DNA Methylation;Doctor of Philosophy;early detection biomarkers;Early identification;Endoscopy;Environment;Environmental Risk Factor;Epigenetic Process;epigenome;Exhibits;experience;Fecal occult blood;Frequencies;Gene Expression;Genes;Genetic;genetic variant;high risk;high risk population;improved outcome;in vitro Model;Incidence;Individual;Intervention;Malignant Neoplasms;Measures;men;Methylation;methylation pattern;Modeling;Molecular;mortality risk;Mucous Membrane;Neighborhoods;Organoids;Outcome;patient population;patient subsets;Patients;peripheral blood;Phenotype;Pilot Projects;Polyps;Population;Positioning Attribute;pre-clinical;predictive marker;Prevalence;Prevention;Preventive treatment;Procedures;Quantitative Trait Loci;Questionnaires;racial disparity;randomized trial;Recording of previous events;Research Project Grants;research study;Risk;Saliva;saliva sample;Scientist;screening;Screening for cancer;Screening procedure;social determinants;socioeconomics;Subgroup;systemic barrier;Testing;Time;tool;tumorigenesis;United States;University Hospitals;uptake;Variant;Woman

PROJECT_TITLE: Full Research Project 2: Changes in DNA methylation phenotype in CRC associated with racial disparities


NIH_SPENDING_CATS: Bioengineering;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Pediatric;Physical Injury - Accidents and Adverse Effects;Unintentional Childhood Injury

ORG_CITY: SAINT PAUL

ORG_NAME: MINNESOTA HEALTHSOLUTIONS CORPORATION

ORG_STATE: MN

PHR: Project Narrative Motor vehicle crashes are a leading cause of unintentional morbidity and mortality among children in the United States and a leading cause of brain injury. A total of 3,355 children ages 0 to 8 died as an occupant in a motor vehicle crash from 2016 to 2020 and hundreds of thousands more had injuries that required treatment. We aim to develop a significantly easier to use intuitive harness tensioning system that improves child safety seats and better protects children riding in motor vehicles.

PI_NAMEs: SEIFERT, SARA  (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: Acceleration;Age;American;Area;arm;Biomechanics;Brain Injuries;Caregivers;Cessation of life;Chest;Child;Childhood Injury;Clip;Collaborations;commercialization;Complex;design;Doctor of Philosophy;Effectiveness;Engineering;Ensure;Epidemiologist;experience;Failure;Feedback;Generations;Head;head impact;Hip region structure;Hospitals;human study;human subject;improved;Injury;injury prevention;innovation;Intuition;Knowledge;Laboratories;Leg;Manufacturer;Marketing;Mechanics;Methods;Minnesota;Morbidity - disease rate;mortality;Motion;Motor Vehicles;novel;Ohio;Positioning Attribute;prevent;Process;product development;Production;prototype;Public Health;Recording of previous events;Research;Research Personnel;Resources;restraint;Safety;Secure;Security;Shoulder;Sledding;Specific qualifier value;success;Surface;System;Technology;Testing;United States;Universities;usability;Vehicle crash;Work

PROJECT_TITLE: Intuitive Child Safety Seat to Increase Security


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Sleep Research;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE  Central sleep apnea, a condition where people stop breathing in their sleep, can be caused by medications used to treat opioid use disorder. This project will evaluate whether central sleep apnea, by worsening sleep and causing low blood oxygen levels, may lead to nighttime arousal and emotional distress, which in turn may increase risk of drug relapse in patients receiving treatment for opioid use disorder.

PI_NAMEs: PATEL, SANJAY R (contact)

PROGRAM_OFFICER_NAME: NAIR, SUNILA GOPI

PROJECT_TERMS: Acetazolamide;Acute;Address;Adult;Adverse effects;adverse outcome;American;Anxiety;Arousal;Automobile Driving;Autonomic Dysfunction;Autonomic nervous system;Blood;Brain Stem;Breathing;Buprenorphine;Central Sleep Apnea;Chemoreceptors;Chronic;circadian;Clinical;Clinical Treatment;clinically significant;cohort;common symptom;Data;Dropout;Drowsiness;drug craving;drug relapse;effective therapy;emotional distress;Enrollment;Epidemic;Equilibrium;Feedback;Geographic Locations;High Prevalence;Home;Hypoxemia;improved;improved outcome;improvement on sleep;Individual;Intervention;Knowledge;Measures;Mediating;medication for opioid use disorder;Mental Depression;Methadone;Morbidity - disease rate;mortality;Nervous System Physiology;novel;Opioid;opioid mortality;opioid use;opioid use disorder;Outcome;overdose death;Oxygen;Pathogenesis;Pathway interactions;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Physiological;Placebos;Play;Polysomnography;Population;Population Control;Protocols documentation;public health emergency;randomized trial;Relapse;response;retention rate;Risk;Role;Secondary to;Site;Sleep;Sleep Apnea Syndromes;sleep difficulty;Sleep Disorders;Sleep Fragmentations;sleep quality;Sleeplessness;Testing;Time;Treatment outcome;treatment program;ventilation;Virus Diseases;Work

PROJECT_TITLE: The impact of central sleep apnea in patients receiving medications for opioid use disorder


NIH_SPENDING_CATS: Cancer;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;HPV and/or Cervical Cancer Vaccines;Health Services;Immunization;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Sexually Transmitted Infections;Social Determinants of Health;Vaccine Related

PROJECT_TERMS: 15 year old;Address;Affect;Africa;aged;apprenticeship;Area;Awareness;Behavior;Cancer Control;cancer prevention;Characteristics;Charge;Climate;Clinical;Communities;community based participatory research;community clinic;Community Participation;community setting;Consolidated Framework for Implementation Research;cost;Country;crowdsourcing;Data;Death Rate;Decentralization;Development;Dose;Effectiveness;effectiveness/implementation design;Elements;Eligibility Determination;Equity;Evaluation;evidence base;Evidence based intervention;experimental study;Friends;Geography;girls;Guidelines;Health;Health Services;HIV;HPV vaccine acceptance;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papilloma Virus-Related Malignant Neoplasm;Human Papillomavirus;Hybrids;implementation facilitators;implementation outcomes;implementation process;implementation science;implementation strategy;implementation/effectiveness;Improve Access;improved;Incidence;Individual;innovation;Intervention;Leadership;Malignant Neoplasms;Medical Research;Mentorship;Methods;Modeling;Nigeria;Nigerian;Policies;policy recommendation;post implementation;preference;prevent;prevention service;primary outcome;Private Sector;programs;Randomized, Controlled Trials;Records;recruit;Research;Research Project Grants;Resources;Risk;Sampling;scale up;secondary outcome;self testing;Services;skills;social;Social support;supportive environment;Testing;Time;tool;Training;Translations;treatment as usual;uptake;Vaccination;vaccine acceptance;vaccine access;Vaccines;Youth

PROJECT_TITLE: Research Project 1


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Orphan Drug;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: NARRATIVE Many patients with ovarian cancer suffer and even die from blood clots. Our goal is to determine the risk factors for blood clots in ovarian cancer. We will use tumor specimens, blood samples from patients, and extensive clinical and laboratory data available in our institution to achieve our goals.

PI_NAMEs: AFSHAR-KHARGHAN, VAHID  (contact);SHETH, RAHUL ANIL;SOOD, ANIL K

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Adjuvant Chemotherapy;Antibiotics;Anticoagulation;Antioxidants;Biochemical;Biological Markers;biomarker identification;Blood;Blood coagulation;Blood Platelets;Blood specimen;cancer cell;cancer diagnosis;cancer genome;Cancer Patient;carcinogenesis;Cells;chemotherapy;Clinical;clinical database;cohort;Data;Early Intervention;extracellular;extracellular vesicles;Fibrinolytic Agents;Gene Expression;Gene Expression Profile;General Population;Generations;Genes;genetic makeup;Genetic Markers;genetic risk factor;genetic variant;Goals;Haplogroup;Hemorrhage;Hemostatic Agents;high risk;improved;inhibitor;Injections;Institution;Laboratories;Ligation;Malignant neoplasm of brain;Malignant neoplasm of ovary;Malignant Neoplasms;Methionine;microvesicles;Mitochondria;Mitochondrial DNA;Mitochondrial Proteins;Modeling;Moon;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Neoadjuvant Therapy;neutrophil;novel;novel marker;Nuclear;ovarian neoplasm;Patients;Peptides;Plasma;podoplanin;predictive marker;prevent;programs;prophylactic;Reactive Oxygen Species;Reagent;Risk;Risk Factors;Role;Sampling;small molecule;Somatic Mutation;Specimen;Thrombophilia;Thrombosis;thrombotic;Thrombus;tumor;tumor DNA;Tumor-Derived;University of Texas M D Anderson Cancer Center;Venous;venous thromboembolism;Venous Thrombosis;vesicular release

PROJECT_TITLE: Novel Biomarkers Predicting Blood Clots in Ovarian Cancer

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: CONNOLLY, DENISE C (contact)

PROJECT_TERMS: Address;Affect;African American;African American population;African ancestry;aggressive breast cancer;American;animal imaging;Animals;Basic Research Breast Cancer;Bioinformatics;Biological;Biological Markers;biological research;Biological Specimen Banks;Biology;Biometry;Black American;Black race;BRCA mutations;BRCA1 gene;Breast Cancer Cell;Breast Cancer Patient;Cancer Biology;cancer biomarkers;cancer health disparity;Cancer health equity;cancer subtypes;Cell Culture Techniques;Cell Line;Cells;Chromosomes;Clinical;cohort;Collaborations;college;Communities;community engagement;Community Outreach;Complex;data acquisition;Data Analyses;Detection;Diagnosis;Disparity;DNA biosynthesis;DNA Damage;DNA Repair Pathway;Doctor of Philosophy;education research;Educational workshop;Eligibility Determination;empowerment;Ethics;Ethnic Origin;European;Exposure to;follower of religion Jewish;Fox Chase Cancer Center;Gene Amplification;Genetic Engineering;Genetic Screening;Goals;health disparity;Health Fairs;Human;Imaging technology;Immunohistochemistry;improved;Informed Consent;inhibitor therapy;insight;Institution;Learning;Malignant Breast Neoplasm;Malignant Neoplasms;MDM2 gene;Mentors;Microarray Analysis;minority engagement;minority trainee;Molecular Biology;Morbidity - disease rate;mortality;mouse model;mutant;Mutation;mutation carrier;Neoplasm Circulating Cells;next generation;novel;Outcome;Participant;Pathology;Pathway interactions;patient derived xenograft model;Patients;Pilot Projects;Play;Poly(ADP-ribose) Polymerase Inhibitor;Poly(ADP-ribose) Polymerases;Population;Probability;Proliferating;protein expression;Proteins;Race;replication stress;Research;Research Personnel;Research Project Grants;Resources;reverse genetics;Risk;Role;Sampling;Scientist;screening;Signal Transduction;Specimen;Stains;Students;systemic barrier;targeted treatment;temozolomide;Testing;therapeutic target;Tissue Microarray;Tissues;TP53 gene;Training;triple-negative invasive breast carcinoma;tumor;Tumor Tissue;Underrepresented Minority;Underrepresented Students;Universities;university student;Woman;Work;Xenograft procedure

PROJECT_TITLE: Pilot Research Project: Evaluating Black and African American Breast Cancer Populations  for Therapeutic Targeting of Aberrant p53, MDM2, MDMX, and PARP signaling


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Climate-Related Exposures and Conditions;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tickborne Diseases;Vector-Borne Diseases

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative This project develops new strategies for vector-borne disease surveillance. By leveraging novel data streams, these approaches will reduce surveillance cost, improve the accuracy of surveillance procedures, and allow for risk quantification in real-time.

PI_NAMEs: SELF, STELLA COKER WATSON (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: accurate diagnosis;Amblyomma;Ambylomma americanum;Annual Reports;Area;Arizona;Bacteria;Biocompatible Materials;Case Fatality Rates;Case Study;Centers for Disease Control and Prevention (U.S.);Climate;Collection;Complication;cost;cost effective;cost efficient;Data;data streams;data structure;Delaware;Dermacentor;design;Diagnosis;Diagnostic;Disease;Disease Surveillance;disorder risk;Doxycycline;empowerment;Environment;Environmental Risk Factor;Exposure to;Fever;Financial Hardship;Future;Geographic Distribution;Geography;Goals;Guidelines;gulf coast;Habitats;Health Personnel;Illinois;improved;Incidence;Infection;interest;Laboratories;land cover;machine learning method;Methods;Midwestern United States;Modeling;Monitor;Municipalities;Nature;novel;pathogen;Pathogenicity;Patients;Pattern;Population;Predisposition;Procedures;Process;Public Health;Reporting;Reproduction;Rhipicephalus sanguineus;Rickettsia;Rickettsia Infections;Rickettsia parkeri;Rickettsia rickettsii;Risk;Rocky Mountain Spotted Fever;South Carolina;Spatial Distribution;spatiotemporal;Specimen;spotted fever;Statistical Methods;Statistical Models;Surveillance Methods;surveillance strategy;Techniques;Testing;Tick-Borne Diseases;Ticks;Time;tool;trend;United States;Update;vector;vector tick;vector-borne infection;Vector-transmitted infectious disease;Weather;weather patterns

PROJECT_TITLE: Developing New Statistical Methods for Vector-Borne Disease Surveillance to Improve Accuracy while Reducing Cost

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Dissemination and Implementation Research;Hepatitis;Hepatitis - B;Immunization;Infectious Diseases;Liver Cancer;Liver Disease;Pediatric;Prevention;Rare Diseases;Vaccine Related

PROJECT_TERMS: Adult;Africa;African;Automobile Driving;Birth;Cancer Control;Caring;Cessation of life;Child;China;Chronic Hepatitis B;chronic infection;Clinic;Clinical;cohort;Communities;community clinic;Community Developments;community engagement;Community Health Aides;concept mapping;Consolidated Framework for Implementation Research;Country;Creativeness;crowdsourcing;Data;Decentralization;Dose;effectiveness evaluation;effectiveness/implementation design;Elements;emerging adult;Engineering;Equity;Evaluation;Face;Guidelines;HBV Liver Cancer;Health Services;Hepatitis;Hepatitis B;Hepatitis B Infection;Hepatitis B Transmission;Hepatitis B Vaccines;Hepatitis B Virus;Home;Hospitals;Hour;Hybrids;Immunity;Immunization;implementation outcomes;implementation process;implementation research;implementation science;implementation strategy;Individual;Infant;infant infection;innovation;Intervention;Liver diseases;low and middle-income countries;Malignant neoplasm of liver;mathematical model;Measures;Medicine;Mothers;National Cancer Institute;neonatal infection;Newborn Infant;Nigeria;Nigerian;Persons;Policies;Population;post implementation;preference;Pregnant Women;Prevention;Primary carcinoma of the liver cells;primary outcome;Printing;Protocols documentation;Randomized, Controlled Trials;Recommendation;Records;Request for Applications;Research;Research Methodology;Research Project Grants;Risk;secondary outcome;Services;Site;standard care;testing uptake;Time;Training;United States National Academy of Sciences;United States National Institutes of Health;uptake;Vaccination;vaccine acceptance;vaccine delivery;Vaccines;Vertical Disease Transmission

PROJECT_TITLE: Research Project 2


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PROJECT_TERMS: Address;Adopted;Advanced Malignant Neoplasm;Area;Benchmarking;cancer care;cancer health disparity;Cancer health equity;Clinical;Collaborations;college;Communication;Communities;community based research;community engagement;Community Outreach;Consensus;Consensus Development;cost;Data;Data Collection;design;Development;Doctor of Philosophy;Education and Outreach;Ensure;Equity;Evaluation;experience;Feedback;formative assessment;Foundations;Fox Chase Cancer Center;functional independence;Funding;Goals;Grant;Grant Review;Health Disparities Research;health equity;Health Policy;Health system;Impact evaluation;improved;Individual;Information Dissemination;Infrastructure;innovation;Institution;Leadership;Logic;Measures;member;Mentors;Mentorship;Methods;Minority Groups;Modeling;Monitor;Online Systems;Outcome;Peer Review;Phase;Play;Policies;population health;Positioning Attribute;preservation;Procedures;Process;Productivity;programs;Publications;Recommendation;Reporting;repository;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;senior faculty;sharing platform;social;success;System;systemic barrier;Technology;Training;underserved minority;United States National Institutes of Health;Universities;Vision;Work

PROJECT_TITLE: Planning and Evaluation Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: SANTA BARBARA

ORG_NAME: PACIFIC OPTICA, INC.

PHR: Project Narrative This Small Business Technology Transfer project will develop new optical components for biomedical imaging. The biomedical imaging enabled by these products can lead to improved understanding of neurobiology and other aspects of biology, ultimately leading to new strategies for enhancing health.

PI_NAMEs: SMITH, SPENCER LAVERE (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TITLE: Advanced optics to unlock large field-of-view multiphoton imaging for neuroscience and beyond

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-G(13)B]


PI_NAMEs: GRANA, XAVIER  (contact)

PROJECT_TERMS: Address;Admission activity;anti-cancer research;Award;Basic Science;Biomedical Research;cancer education;cancer health disparity;career;career development;Career Mobility;CCL7 gene;Clinical;Clinical Sciences;cohort;Collaborations;college;Communication;Communities;community academic partnership;community collaboration;community engaged research;Community Networks;Community Outreach;community partners;community research;Complement;Comprehensive Cancer Center;Core Facility;Data;design;Development;Diverse Workforce;Doctor of Philosophy;Education Projects;education research;Educational Activities;Educational process of instructing;Enrollment;Environment;Ethnic Origin;experience;Faculty;Feedback;Fellowship;First Generation College Students;Fostering;Fox Chase Cancer Center;Funding;Goals;graduate student;Grant;Growth;Health;Health Disparities Research;health disparity;Health Promotion and Education;Inequity;innovation;Institution;inter-institutional;Interdisciplinary Study;Malignant Neoplasms;Measurable;Medical;medical schools;Mentors;Mentorship;minority communities;Minority Groups;Minority Health Research;Minority-Serving Institution;multidisciplinary;novel;Pathway interactions;Pilot Projects;Population;population based;Population Sciences;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;professional students;programs;Qualifying;racial minority;Research;Research Infrastructure;Research Institute;Research Personnel;Research Project Grants;Research Project Summaries;Research Support;Research Training;Rotation;Science;skills;Special Population;student mentoring;Students;systemic barrier;Training;Training Activity;Training and Education;training opportunity;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved community;underserved minority;United States National Institutes of Health;Universities;university student;Work

PROJECT_TITLE: Research Education Core


NIH_SPENDING_CATS: Aging;Cancer;Cervical Cancer;Clinical Research;Genetics;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Radiation Oncology;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Human papillomavirus (HPV)-associated cervical cancer remains one of the leading causes of cancer mortality in People Living with Human Immunodeficiency Virus ([HIV] PLWH) in underserved, low- and middle-income countries. PLWH have evidence of premature aging, which could contribute to cervical cancer progression and responses to chemoradiation therapy (CRT). To identify potential biological biomarkers of aging, the proposed project will focus on measuring differences in epigenetic changes between HIV-positive vs HIV-negative cervical cancer patients before and after CRT and correlating these changes with immunological phenotype for use in future clinical studies.

PI_NAMEs: COGHILL, ANNA ;LIN, LILIE LEMING (contact);MSADABWE, SUSAN CITONJE

PROGRAM_OFFICER_NAME: LIDDELL HUPPI, REBECCA

PROJECT_TERMS: accelerated epigenetic aging;Acceleration;Acquired Immunodeficiency Syndrome;Acute;Africa South of the Sahara;Age;age acceleration;age related changes;Age Years;aged;Aging;aging biomarker;aging population;aging process;antiretroviral therapy;bead chip;Biological;biological age;Biological Aging;Biological Assay;Biological Clocks;Biological Factors;Blood;Cancer Center;cancer diagnosis;Cancer Etiology;cancer health disparity;Cancer Patient;cancer therapy;Cells;Cervical Cancer Screening;chemoradiation;Chemotherapy and/or radiation;Chronic;Chronology;Clinical;Clinical Data;Clinical Research;clinically relevant;Collaborations;comorbidity;Data;Diagnosis;Disease;disparities in women;Disparity;Disproportionately impacts women;DNA;DNA analysis;DNA Methylation;Elderly;Epidemiology;Epigenetic age;epigenetic aging;Epigenetic Process;exhaust;Flow Cytometry;Future;Geographic Locations;health disparity;Hematology;HIV;HIV Infections;HIV Seronegativity;HIV Seropositivity;Hospitals;Human Papillomavirus;Immune;Immune Evasion;immune function;Immune System Diseases;Immunity;Immunologics;Immunology;Immunosuppression;Incidence;Income;Individual;Inferior;Knowledge;Life Expectancy;life span;Link;Location;low and middle-income countries;Maintenance;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Measurable;Measures;Mediating;methylation pattern;methylome;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;novel therapeutics;older women;Oncogenic;Oncology;Outcome;outcome disparities;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Play;Population;Premature aging syndrome;Prevalence;Radiation Oncology;receptor;Recurrence;Regimen;Relapse;Resistance;response;Role;Sampling;side effect;Site;socioeconomics;standard of care;Swab;T-Lymphocyte;Testing;Time;Toxic effect;Translating;Translational Research;Treatment outcome;Treatment-related toxicity;tumor;tumor progression;Tumor-infiltrating immune cells;tumorigenesis;underserved community;United States;Virus Diseases;Whole Blood;Woman;women of color;Women's mortality;Work;Zambia

PROJECT_TITLE: The Impact of Biologic Aging on Immunity-Related Cervical Cancer Outcome Disparities Among Women Living with HIV in Zambia


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: Aurora

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: Project Narrative Predicting epilepsy outcomes over time for a given patient is a significant challenge due to the large variability in the patient-specific course of disease. We propose to leverage our access to data from the Human Epilepsy Project, a large observational study of 450 patients with focal epilepsy, to develop novel prediction models for seizure trajectories that address substantial variability and clumping in seizure frequency. This work will assistant patients and clinicians identify optimal treatment earlier; for instance, this could help limit the amount of time patients are receiving ineffective medication and improve time to epilepsy surgical evaluation when indicated.

PI_NAMEs: FRENCH, JACQUELINE A.;JUAREZ-COLUNGA, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: WHITTEMORE, VICKY R

PROJECT_TERMS: Absence Epilepsy;Accounting;Address;Affect;American;Area;asthma exacerbation;Bayesian Modeling;Brain;Clinical;clinically relevant;Colorado;cost;Data;Data Set;Diagnosis;Disease;Early treatment;Earthquakes;Epilepsy;Evaluation;Event;experience;Frequencies;Goals;Grant;graphical user interface;Heterogeneity;Human;human data;improved;Individual;individual variation;Joints;lifetime risk;Lung;member;Methodology;Methods;Modeling;Modernization;Multiple Sclerosis;Nature;novel;Observational Study;Operative Surgical Procedures;optimal treatments;Outcome;Partial Epilepsies;Patients;Pattern;personalized predictions;Pharmaceutical Preparations;Physicians;Population;predictive modeling;predictive tools;Probability;Process;Recording of previous events;Recurrence;Relapse;Research;Resistance;Seizures;social media;Statistical Data Interpretation;Statistical Methods;Subgroup;Technology;therapy resistant;Time;tool;United States;user-friendly;Visualization;web app;Work

PROJECT_TITLE: Modeling seizures in patients with focal epilepsy


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PI_NAMEs: TAN, YIN  (contact)

PROJECT_TERMS: Acculturation;Achievement;Address;African American;African American population;anti-cancer research;Asian Pacific American;Awareness;Black race;Breast Cancer Detection;Cancer Burden;cancer health disparity;cancer risk;Clinical;Collaborations;Colorectal Cancer;colorectal cancer screening;Communication;Communities;community advisory board;community based participatory research;community engaged approach;community engagement;community organizations;Community Outreach;Community Participation;community partners;community research;Competence;COVID-19 pandemic;Diagnosis;Disparity;Doctor of Philosophy;Education;education research;Educational Curriculum;Equity;ethnic minority;ethnic minority population;Ethnic Population;Evaluation;evidence base;Evidence based intervention;experience;Faith-based organization;Fostering;Fright;Funding;Genetic;Genetic Enhancement;genetic testing;Genetic testing for cancer risk;Genomics;Geographic Locations;Goals;Hispanic Americans;Impact evaluation;improved;Infrastructure;Inherited;Institutionalization;Intervention;Knowledge;Language;Logic;low health literacy;low socioeconomic status;Malignant Breast Neoplasm;Malignant Neoplasms;Medical;Methods;Modeling;Monitor;New York City;Outcome;outreach;Outreach Research;Population;Process;Program Evaluation;programs;Race;racial minority;racial minority population;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Resources;Risk Assessment;Scientist;screening;Screening for cancer;screening program;service providers;service utilization;social health determinants;success;systemic barrier;Test Result;Testing;testing services;tool;training opportunity;Woman;Yin

PROJECT_TITLE: Community Outreach Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Dietary Supplements;Drug Abuse (NIDA only);Neurosciences;Nutrition;Pediatric;Substance Misuse

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Membrane transporters in the blood vessels of the brain serve as gatekeepers to allow access of essential nutrients into the brain and to facilitate elimination of potentially toxic compounds. In this research, we will systematically identify psychoactive drugs, nutrients and constituents of dietary supplements that are transported by membrane transporters in brain capillaries. This research will lead to a new understanding of transporters in human brain capillaries as well as sharable data and resources that will be available to the scientific community.

PI_NAMEs: GIACOMINI, KATHLEEN M (contact);STROUD, ROBERT M

PROGRAM_OFFICER_NAME: WEINBERG, DAVID H

PROJECT_TERMS: Address;Antibodies;ATP-Binding Cassette Transporters;Binding;Biological Assay;Biological Process;Biology;Blood - brain barrier anatomy;Blood capillaries;blood-brain barrier function;Brain;California;Capillary Endothelial Cell;Categories;Cell Line;Cell model;cerebral capillary;Cerebrovascular system;Chemicals;Communities;comparative;Computational Biology;Cryoelectron Microscopy;Data;dietary constituent;dietary supplements;Docking;drug discovery;Drug Prescriptions;Drug Targeting;Endothelial Cells;Epithelial Cells;Epitopes;Fetal Development;G-Protein-Coupled Receptors;Gatekeeping;Gene Family;Goals;Homeostasis;Hormones;Human;Human Genome;Immunohistochemistry;in silico;Infant;Informatics;inhibitor;interest;Knowledge;Libraries;Ligands;Macronutrients Nutrition;Mammary gland;member;Membrane;Membrane Transport Proteins;Mitochondria;Modeling;Molecular Structure;Movement;multidisciplinary;Nutrient;Opioid;Orphan;Pharmaceutical Preparations;Pharmacology;Placenta;Play;Poison;polarized cell;programs;protein data bank;protein structure;Proteomics;psychostimulant;Psychotropic Drugs;Recombinants;Research;Research Personnel;Research Support;Resources;response;Role;Sampling;San Francisco;Scientist;Sea;Signaling Molecule;solute;Specificity;structural biology;Structural Models;Structure;System;Testing;Tight Junctions;Tissues;tool;Transmembrane Transport;Transport Process;Universities;virtual screening;Work;Xenobiotics

PROJECT_TITLE: Transporter Elucidation Center at the University of California, San Francisco


NIH_SPENDING_CATS: Chronic Pain;Digestive Diseases;Neurosciences;Pain Research

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: While chronic visceral pain afflicts about 10% of the population globally, including in the U.S., and produces life-long physical and psychiatric burdens on patients and their families, this syndrome has no known causes and is without satisfactory therapeutic options. This proposal will explore the novel disease mechanism that there is a previously unrecognized link between hormones secreted by the intestine and the development of hypersensitivity of nerves in the gut. The working hypothesis suggests that those hormones can be used as oral drugs to eliminate the hypersensitivity of nerves in the gut, to treat and prevent chronic visceral pain.

PI_NAMEs: COVARRUBIAS, MANUEL L;WALDMAN, SCOTT A (contact)

PROGRAM_OFFICER_NAME: ANDERSEN, DANA K

PROJECT_TERMS: Abbreviations;Absence of pain sensation;Action Potentials;Acute;Affect;Afferent Neurons;Agonist;Agreement;Analgesics;analog;Anatomy;Anti-Inflammatory Agents;Binding;Catalytic Domain;Cells;Cholecystokinin;Chronic;Clinical;Colorectal;colorectal distension;Constipation;cost;Cyclic GMP;Cyclic Nucleotides;Data;Development;Diarrhea;Disease;disorders of gut-brain interaction;Distal;dorsal horn;Elements;Enterocytes;enterotoxin receptor;Enterotoxins;Etiology;Extracellular Domain;Family;FDA approved;Fire - disasters;Functional disorder;Genetic;Guanosine Triphosphate;Homologous Gene;Hormone secretion;Hormones;Hyperalgesia;Hypersensitivity;In Vitro;in vivo;Inflammation;inhibitor;insight;Intestinal Secretions;Intestines;Irritable Bowel Syndrome;Link;Mediating;Modeling;Molecular;Mus;Nerve;neuronal excitability;Neurons;neuropsychiatric disorder;neurotransmission;Nociception;Nociceptors;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutics;Opioid;optogenetics;Oral;Outcome;overexpression;Pain;Pain Disorder;Pain management;pain reduction;pain relief;pain signal;Patients;Peptides;Periodicity;Persons;Pharmaceutical Preparations;pharmacologic;phosphoric diester hydrolase;Population;prevent;Quality of life;receptor;Receptor Activation;recruit;Refractory;repaired;Resistance;response;Rodent;Role;selective expression;side effect;Signal Transduction;Small Intestines;Spinal;Spinal Cord;Spinal Ganglia;Synapses;Syndrome;Testing;Therapeutic;Translating;uroguanylin;Visceral;Visceral Afferents;Visceral pain

PROJECT_TITLE: Targeting visceral pain through intestinal neuropod cell GUCY2C signaling


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: CORAL GABLES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This application aims to investigate the impact of HIV brain infection and amyloidopathy on ischemic microinfarcts, a major comorbidity in people living with HIV (PLWH), in the context of aging. The central hypothesis is that a procoagulant environment driven by elevated Serpine-1 levels contributes to increased risk of ischemic events, delayed post-ischemic recovery, and enhanced amyloidopathy in HIV-infected brain. The obtained results will have a potential to generate new therapeutic targets and strategies in aging and HIV-1 infection, especially in prevention and treatment of cerebrovascular comorbidities, including ischemic events.

PI_NAMEs: TOBOREK, MICHAL  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: abeta accumulation;Affect;Age;age acceleration;age group;age related biomarkers;aged;Aging;Alteplase;Amyloid;Amyloid beta-Protein;amyloid pathology;antiretroviral therapy;Biological;biological age;Blood - brain barrier anatomy;Blood Vessels;blood-brain barrier disruption;Brain;Cerebral endothelium;cerebral microvasculature;cerebrovascular;Cerebrovascular Disorders;cerebrovascular pathology;Chronic;clinically relevant;Cognitive deficits;cognitive enhancement;comorbidity;Complex;Country;Deposition;Development;Endothelial Cells;Environment;Epigenetic age;Event;experience;extracellular vesicles;Fibrinolysis;Frequencies;Funding;General Population;Generations;gray matter;Health;HIV;HIV diagnosis;HIV Infections;HIV-1;Impairment;improved;Individual;Infarction;Infection;Inflammatory Response;inhibitor;Ischemia;ischemic injury;Ischemic Stroke;Laboratories;Literature;Maps;methylome;migration;Mitochondria;Nerve Degeneration;nerve stem cell;Neurocognitive Deficit;neurogenesis;neuroinflammation;new therapeutic target;novel;Older Population;Parents;Pathway interactions;Peptides;Persons;Physiological;Plasmin;Plasminogen;Plasminogen Activator Inhibitor 1;Prevention;Production;Proteins;Proteolysis;Recovery;Reporting;Research;Risk;Role;Severities;Technology;Urokinase

PROJECT_TITLE: HIV-1 and amyloid beta interactions at the blood-brain barrier

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer;Orphan Drug;Ovarian Cancer;Pancreatic Cancer;Precision Medicine;Rare Diseases;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: PROJECT NARRATIVE The objective of this project is to determine the genes regulating tumor composition and facilitating tumor growth and resistance to immunity & immunotherapy, with the goal of identifying factors that can be targeted to enhance tumor immunity and improve cancer treatment. We will focus on four highly prevalent and deadly cancers - non small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDAC), high grade serous ovarian cancer (HGSOC), and oral squamous cell carcinomas (OSCC), and utilize large-scale genomic and transcriptomic data from patient tumors, spatial functional genomics, and computational analysis, to reach our goal.

PI_NAMEs: BROWN, BRIAN D (contact);MERAD, MIRIAM ;SAMSTEIN, ROBERT M

PROGRAM_OFFICER_NAME: MCCARTHY, CLAIRE ELLEN

PROJECT_TERMS: Affect;antiangiogenesis therapy;Antibodies;Architecture;Cancer Biology;cancer cell;cancer imaging;cancer therapy;Candidate Disease Gene;candidate identification;Categories;CD8-Positive T-Lymphocytes;Cell Communication;Cell Cycle;Cell Death;Cell Fraction;Cell membrane;cell stroma;Cells;chemokine;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collagen;Collection;Complementary DNA;Computer Analysis;CRISPR screen;cytokine;Data;Development;Drug Targeting;Environment;extracellular;Fibroblasts;fitness;functional genomics;Gene Expression;gene function;Genes;genomic platform;Genomics;Goals;Growth;Head and Neck Cancer;Immune;immune checkpoint blockade;Immunity;Immunocompetent;Immunologic Surveillance;immunosuppressed;Immunotherapy;improved;In Situ;in vivo;Infiltration;innovation;insight;Invaded;Knock-out;Knowledge;Ligands;Machine Learning;Macrophage;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of pancreas;Malignant Neoplasms;Maps;Measures;Mediating;Modeling;Morphology;mouse model;mouth squamous cell carcinoma;multiplexed imaging;Mutate;Mutation;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel therapeutic intervention;Oncogenes;Outcome Study;Ovarian Serous Adenocarcinoma;overexpression;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Patients;personalized medicine;Pharmaceutical Preparations;Phenotype;Positioning Attribute;predicting response;preservation;Process;Publishing;recruit;refractory cancer;Resistance;Resolution;response;Role;Selection for Treatments;Serous;Solid Neoplasm;T cell therapy;Testing;The Cancer Genome Atlas;therapy resistant;transcriptomics;treatment response;tumor;tumor behavior;Tumor Biology;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Associated Process

PROJECT_TITLE: Spatial functional genomics to identify regulators of the tumor microenvironment and cancer immunity


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Liver Disease and Cirrhosis;Clinical Research;Digestive Diseases;Liver Cancer;Liver Disease;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE  It is imperative to develop new noninvasive tools for the detection of curable hepatocellular carcinoma, as this improves survival in these patients. We propose a rigorous and systematic evaluation of liquid biopsy (detection of tumor components released to the bloodstream) and magnetic resonance imaging (MRI)-based radiomics in a large multiracial multi-institutional cohort of early-stage HCC and controls at high risk for HCC development. Our project is very timely and uniquely positioned to improve early HCC detection.

PI_NAMEs: TAOULI, BACHIR ;VILLANUEVA, AUGUSTO  (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: Abdomen;Ablation;Acceleration;accurate diagnosis;Address;Adoption;Benign;biobank;Biological Markers;Biopsy;Blood;Blood Circulation;blood-based biomarker;Breakthrough device;Cancer Etiology;Cancerous;cell free DNA;Center for Translational Science Activities;Cessation of life;Cirrhosis;Clinical;Clinical Data;Clinical Practice Guideline;cohort;Collaborations;Collection;curative treatments;Data;Descriptor;design;Detection;Development;Diagnosis;diagnostic value;Disease;early detection biomarkers;Early Diagnosis;Enrollment;Ensure;Etiology;Evaluation;extracellular vesicles;follow-up;Goals;Guidelines;high risk;high risk population;Image;improved;Institution;Laboratories;Lesion;liquid biopsy;Liver;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Measures;member;Methods;Modeling;Molecular;multi-racial;New York;Nodule;Nomograms;Notification;novel;Nucleic Acids;Operative Surgical Procedures;overtreatment;patient population;Patients;Performance;Phase;Plasma;Populations at Risk;Positioning Attribute;Prevention;Primary carcinoma of the liver cells;Probability;programs;Prospective cohort;Radiology Specialty;radiomics;Recommendation;Reproducibility;Resources;Risk;Role;Sampling;Sensitivity and Specificity;Serum;Small RNA;Surveillance Program;Technology;technology validation;Testing;tool;Training;tumor;ultrasound;United States;Validation;Vesicle;α-Fetoproteins

PROJECT_TITLE: Liquid biopsy and radiomics for liver cancer surveillance


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_NAME: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

PHR: PROJECT NARRATIVE Stress plays a key role in the development and maintenance of alcohol use disorder (AUD) and can trigger relapse. The stress response is regulated by the corticotrophin-releasing factor (CRF) system, and we have developed in vitro chemical probes that inhibit the CRFBP-CRF2 complex. We propose to develop systemically active, small molecule CRFBP-CRF2 probes to validate CRFBP-CRF2 as a target in vivo and to facilitate the development of effective drug treatments targeting CRFBP for AUD.

PI_NAMEs: SHEFFLER, DOUGLAS J (contact)

PROGRAM_OFFICER_NAME: SENEVIRATNE, CHAMINDI

PROJECT_TERMS: acamprosate;Adult;Affect;alcohol abuse therapy;Alcohol consumption;alcohol use disorder;Alcohols;Amygdaloid structure;Area;Attention;Behavior Therapy;Binding;biological adaptation to stress;Biological Assay;Brain;C-terminal;Cause of Death;Cell Nucleus;Cell surface;Cells;Cessation of life;Chemicals;Chemistry;Clinical;Clinical Trials;Collaborations;Complex;corticotropin releasing factor-binding protein;Corticotropin-Releasing Hormone;Counseling;CRF receptor type 1;CRF receptor type 2;Data;design;Development;Disease;Disulfiram;Down-Regulation;drug discovery;Drug Kinetics;Drug Metabolic Detoxication;druggable target;effective therapy;Ethanol dependence;Exhibits;Genes;Glutamates;high throughput screening;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;In Vitro;in vivo;in vivo evaluation;innovation;interdisciplinary approach;Interdisciplinary Study;knock-down;Laboratories;lead optimization;lead series;Maintenance;Measures;Mediating;Medical;Mus;N-Methylaspartate;N-terminal;Naltrexone;Nervous System Disorder;novel;Pattern;Peptides;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Play;Positioning Attribute;postsynaptic;programs;Property;protein expression;psychologic;Public Health;Rattus;Relapse;Research Personnel;response;Rodent Model;Role;Series;small molecule;Social Problems;Stress;Structure-Activity Relationship;Synapses;System;targeted treatment;Testing;therapeutically effective;United States;United States Food and Drug Administration;Ventral Tegmental Area

PROJECT_TITLE: Optimization of Drug-like Properties of CRFBP-CRF2 Negative Allosteric Modulators for Alcohol Use Disorder

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Hematology;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: The proposed research in this application is relevant to public health and supports the NIH’s mission because the results from the studies will make a major contribution to our understanding of the mechanisms of proteins involved in oncogenic cell signaling pathways. It will also reveal previously unrecognized opportunities for the clinical development of advanced drug candidates. Identifying novel approaches and chemical probes/compounds as novel drugs is likely to produce personalized targeted therapies/precision medicine and significant survival benefits for a greatly underserved patient population.

PI_NAMEs: LAWRENCE, HARSHANI R (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: ACK1 Gene;Address;Advanced Development;Affinity;anti-cancer research;Applications Grants;Automobile Driving;Award;Biology;Cancer Center;Cancer Center Support Grant;Center Core Grants;chemical synthesis;Chemicals;clinical development;Collaborations;Communities;Comprehensive Cancer Center;design;Development;Disease;drug candidate;drug discovery;Drug resistance;drug synthesis;drug-like compound;Evaluation;Excipients;experience;Formulation;Goals;Human;Immune Evasion;in vivo;inhibitor;lead optimization;Leadership;leukemia;Libraries;Malignant Breast Neoplasm;Malignant Neoplasms;Medicine;member;Mission;Molecular;Molecular Immunology;Molecular Medicine;Multiple Myeloma;mutant;Mutation;novel;novel strategies;novel therapeutics;Oncogenic;patient population;Peer Review;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Positioning Attribute;precision medicine;preclinical study;Prodrugs;programs;Protein-Serine-Threonine Kinases;Proteins;Proteomics;PTPN11 gene;Public Health;Publications;Research;Research Project Grants;Resource Allocation;scale up;Serine;Signal Pathway;Signal Transduction;small molecule;Sodium Chloride;Solvents;Specialist;Structure;Synthesis Chemistry;targeted treatment;treatment strategy;tumor growth;Tumor Promotion;United States National Institutes of Health;Validation

PROJECT_TITLE: Developing chemical probes for oncogenic signaling pathways


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Lung;Nutrition;Palliative Care;Patient Safety;Prevention

ORG_NAME: THERANOVA, LLC

PHR: Narrative Rapid initiation of enteral feeding via enteral feeding tubes (FTs) is essential to high-risk critically ill elderly patients, however, ensuring accurate FT location requires increased personnel time, increased healthcare costs and potentially detrimental delays in enteral nutrition. Through Phase I and Phase II development, our device offers real-time, accurate mapping of FT location and was granted 510k clearance by the FDA. In this Commercialization Readiness Pilot (CRP) project, we propose to verify automated early detection of airway insertion, refine our second-generation FT with reduced cost of goods to enable commercial launch, and submit a 510(k) application to the FDA.

PI_NAMEs: BURNETT, DANIEL ROGERS (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Accidents;Acids;Admission activity;Age;Age Years;Air;Algorithms;Award;blind;Bronchoscopy;care costs;carina;Caring;Cessation of life;Classification;Clinical Research;clinical research site;Clinical Trials;commercial launch;commercialization;commercialization readiness;cost;cost effective;Coughing;Critical Care;Critical Illness;Data;design;Detection;Development;Devices;Distal;Early Diagnosis;electric impedance;Ensure;Enteral Feeding;Enteral Nutrition;Environment;Esophagus;Failure;Family suidae;Feeding Methods;Freezing;Funding;Future;Gastric Feeding Tubes;Generations;Goals;Grant;Health;Health Care Costs;high risk;hospital care;Hour;human data;human old age (65+);Human Resources;Humidifier;improved;Incidence;infection risk;Injury;Intensive Care Units;Intubation;Iris;Kangaroo;Length of Stay;Location;Lung;manufacture;Maps;Mechanical ventilation;Medical;mental state;Modeling;Monitor;mortality risk;nasogastric feeding;Navigation System;novel;Nutritional;older patient;Participant;patient response;Patient-Focused Outcomes;Patients;Performance;Pharmaceutical Preparations;Phase;phase 1 study;Pilot Projects;Population;porcine model;Positioning Attribute;preservation;prevent;Price;Quality Control;Readiness;Reflex action;Respiratory System;Risk;Roentgen Rays;sensor;Small Business Innovation Research Grant;Specificity;Stomach;System;Testing;Time;Trachea;Tube;United States;ventilation;Ventilator;verification and validation;Visualization;Work

PROJECT_TITLE: A novel enteral feeding system for the earlier and safer delivery of enteral nutrition through continuous monitoring of tip location

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research

PHR: PUBLIC HEALTH RELEVANCE Over four million Americans are admitted to an intensive care unit each year, and mortality for critical illness syndromes such as acute lung injury and sepsis exceeds 25%. This training program will provide post-doctoral scholars with cutting-edge interdisciplinary training in critical care outcomes research across the translational spectrum, creating a scientific workforce with the skills, experience, and expertise to design and execute research studies that will improve patient-centered outcomes for patients with critical illness and acute cardiopulmonary disease.

PI_NAMEs: GIRARD, TIMOTHY D;KAHN, JEREMY M (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TITLE: Multidisciplinary Training in Critical Care Outcomes Research

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SEATTLE

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative Brain aging is the main risk factor for age-related neurodegeneration; however, this process is not well- understood in human cells which impedes our understanding of how to treat neurodegeneration. Here we will use innovative artificial intelligence analysis of multi-omic brain data sets to identify candidate drivers of brain aging. We will modulate these drivers in hiPSC-derived brain cells and assay for cellular aging phenotypes that are also relevant to neurodegeneration.

PI_NAMEs: LEE, SU-IN ;YOUNG, JESSICA ELAINE (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Address;age related;age related neurodegeneration;age-related disease;aged;Aging;aging brain;aging gene;aging mechanism;aging process;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease related dementia;Artificial Intelligence;Astrocytes;Atlases;Autopsy;Biological Assay;Biology of Aging;Brain;brain cell;brain tissue;Candidate Disease Gene;candidate identification;Case/Control Studies;cell age;Cell Aging;Cell Line;Cell model;cell type;Cells;Cellular Assay;Cellular biology;Coculture Techniques;Computational Biology;CRISPR interference;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;Data Set;Disadvantaged;Disease;disease model;DNA Damage;drivers of aging;drug development;Environment;Epigenetic Process;epigenome;experimental study;explainable artificial intelligence;fetal;flexibility;fly;Functional disorder;Gene Expression Profile;Genes;Genetic;Genomics;Goals;hallmarks of aging;healthy aging;Human;Human Biology;human disease;Human Genetics;human induced pluripotent stem cells;improved;In Vitro;in vitro Model;Induced pluripotent stem cell derived human neuron;innovation;insight;intercellular communication;Laboratories;Lead;life span;Longevity;Maps;Methods;Microglia;Mitochondria;mitochondrial dysfunction;Modeling;Molecular;multidisciplinary;Multiomic Data;multiple omics;Mus;Nature;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;neuropathology;novel;Organoids;Outcome;Pathology;Pathway interactions;Phase;Phenotype;Physiology;Process;programs;proteostasis;Protocols documentation;Regulation;Risk Factors;Rodent Model;species difference;stem cell model;System;Techniques;Technology;Testing;Therapeutic;therapy development;Time;Tissues;transcriptome;transdifferentiation;Translating;validation studies

PROJECT_TITLE: Mapping the landscape of the aged human brain for neurodegenerative disease models

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-2 (M2)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: BOZEMAN

ORG_NAME: MONTANA STATE UNIVERSITY - BOZEMAN

ORG_STATE: MT

PHR: PROJECT NARRATIVE: Overall The mission of the Center for American Indian and Rural Health Equity (CAIRHE) is to reduce significant health disparities in Indigenous and rural communities across Montana while developing early-career faculty at Montana State University into a multidisciplinary cohort of independent health equity investigators. The Center achieves its mission through community-based participatory research (CBPR) and public health interventions that are considerate of and consistent with communities’ cultural beliefs.

PI_NAMEs: ADAMS, ALEXANDRA K. (contact)

PROGRAM_OFFICER_NAME: PEI, WUHONG

PROJECT_TERMS: Achievement;Affect;Age;Agriculture;American Indian Women;American Indians;Applications Grants;Award;Belief;binge drinking;Biological Markers;Biomedical Research;career;Caring;catalyst;Cause of Death;Centers of Research Excellence;Cessation of life;chronic liver disease;Clinic;Clinical;cohort;Collaborations;Communities;community based participatory research;community based practice;community collaboration;community engaged research;community engagement;County;Death Rate;Development;Diabetes Mellitus;Disparity;Dissemination and Implementation;driving under influence;early-career faculty;Employment Opportunities;Face;Faculty;Foundations;frontier;Funding;Funding Agency;Geography;Grant;Health;health disparity;Health education;health equity;Health equity research;Health Personnel;Health Science Library;Health system;Healthcare;Heart Diseases;Idaho;improved;Indigenous;indigenous community;Individual;innovation;Institution;Institutionalization;Interdisciplinary Study;Intervention;Intervention Studies;Liver Cirrhosis;low socioeconomic status;Malignant Neoplasms;medical schools;men;mentoring community;Mentors;Mission;Montana;multidisciplinary;National Cancer Institute;next generation;North Dakota;operation;Outcome;Paper;Peer Review;Phase;Pilot Projects;Population Density;Positioning Attribute;programs;Public Health;public health intervention;Publishing;Quality of life;Randomized, Controlled Trials;Research;Research Design;Research Infrastructure;Research Personnel;resilience research;Resource Sharing;Risk Behaviors;Risk Factors;Rural;rural area;Rural Community;rural dwellers;Rural Health;Rural health equity;Science;South Dakota;System;Training;Training Programs;translational health science;Translational Research;Trauma Research;tribal community;Tribes;underserved area;Unhealthy Diet;United States;United States National Institutes of Health;Universities;Utah;Vocational Guidance;Washington;White Women;Work;Wyoming

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-4 (C3)]


NIH_SPENDING_CATS: American Indian or Alaska Native;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: Advisory Committees;American Indians;Award;Benchmarking;Biological Markers;Biomedical Research;career;career development;Caring;Centers of Research Excellence;climate change;Clinical Trials;cohort;Collaborations;Communities;community based participatory research;community based research;community engagement;Core Facility;Counseling;data management;Development;Dissemination and Implementation;early-career faculty;Economic Development;Education;Ensure;Evaluation;Exhibits;Faculty;faculty mentor;Foundations;Funding;Grant;Health;health disparity;health equity;Health equity research;Human;Indigenous;indigenous community;Individual;innovation;Institution;Institutionalization;Interdisciplinary Study;Intervention;Leadership;Letters;Malignant Neoplasms;medical schools;Mentors;Montana;multidisciplinary;National Cancer Institute;National Institute of General Medical Sciences;next generation;Outcomes Research;Phase;Pilot Projects;Positioning Attribute;Program Reviews;programs;Reporting;Request for Proposals;Research;research and development;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;Review Committee;Rural;Rural Community;Rural health equity;Services;success;Targeted Research;Teacher Professional Development;Trauma;tribal community;tribal Nation;United States National Institutes of Health;Universities;Utah;Vocational Guidance;Washington;Work

PROJECT_TITLE: Administrative Core, Center for American Indian and Rural Health Equity (CAIRHE)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: BERTAGNOLLI, ANN THERESE (contact)

PROJECT_TERMS: Address;Agreement;American Indians;Award;Belief;Businesses;Centers of Research Excellence;Collaborations;Communities;community academic partnership;community advisory board;community based participatory research;community based practice;community based research;community center;community collaboration;Community Developments;community engaged research;community engagement;community involvement;Community Networks;Community Participation;community partners;community research;Core Facility;cost;Data;data sharing;design;Development;Education;Education and Outreach;Ensure;Equity;experience;Fostering;Foundations;frontier;Funding;Grant;Health;health communication;health disparity;Health education;health equity;Health equity research;Health Personnel;Huntsman Cancer Institute at the University of Utah;improved;Indigenous;indigenous community;Individual;innovation;Institution;Institutional Review Boards;International;Intervention;Investigation;investigator training;Knowledge;Linguistics;Link;literacy;Maintenance;member;Mentors;Mission;Modeling;Montana;multidisciplinary;Outcome;Outcomes Research;outreach;Ownership;Personal Satisfaction;Phase;Pilot Projects;Population;Postdoctoral Fellow;Process;Productivity;programs;Protocols documentation;Provider;Public Health;Publishing;Recommendation;remote communities;Research;Research Ethics;Research Infrastructure;Research Personnel;research study;Research Support;Research Training;Reservations;Resource Sharing;Resources;Rural;rural area;Rural Community;Rural health equity;Side;Solid;Students;success;timeline;tool;Training;Translating;translational health science;Trauma;tribal community;tribal health;tribal Nation;Tribes;Trust;Underserved Population;Universities;Vulnerable Populations;Washington;webinar

PROJECT_TITLE: Montana IDeA Community Engagement Core, Center for American Indian and Rural Health Equity (CAIRHE)


NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: MARTIN, STEPHEN A (contact)

PROJECT_TERMS: Acceleration;Address;Alcohol consumption;American Indians;Applications Grants;Award;base;Behavior;Biological Markers;biomarker validation;Biomedical Research;career;Centers of Research Excellence;Chronic Disease;Clinical;Clinical Trials;community based research;Community Health;Consultations;COVID-19 testing;Development;Diet;Drug usage;Emotional;Enzyme-Linked Immunosorbent Assay;Ethics;Evaluation;Face;Fees;Funding;Future;Goals;Growth;Growth Factor;Health;health disparity;health equity;Health equity research;Home;Hormones;Immunoassay;improved;indigenous community;Industry;inflammatory marker;innovation;Institution;instrument;instrumentation;interdisciplinary approach;Intervention Trial;Laboratories;Life Style;Link;Liquid Chromatography;Liquid substance;Measures;medical schools;Metabolic Diseases;method development;Methods;Modification;Montana;multidisciplinary;Native-Born;nephrotoxicity;Outcome;Oxidative Stress;pandemic disease;Patient Self-Report;Performance;Phase;Pilot Projects;Play;programs;Protocols documentation;Psyche structure;Public Health;public health research;Reduce health disparities;Research;Research Personnel;Research Project Grants;Robotics;Role;Rural Community;Rural health equity;Rural Population;sample collection;Scientist;Services;social;social health determinants;Socioeconomic Factors;Spectrophotometry;Sustainable Development;System;Time;Training;translational goal;Translational Research;underserved community;Universities

PROJECT_TITLE: Translational Biomarkers Core, Center for American Indian and Rural Health Equity (CAIRHE)