ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Drexel's ComPASS Coordination Center (C3) will provide the leadership, resources, and support to accomplish the goals of the Community Partnerships to Advance Science for Society (ComPASS) Program, a first-of-its- kind national effort to advance health equity in communities that have been shaped by structural and systemic forces and traditionally excluded from, and, at times, harmed, by the research enterprise. Shifting the power back to communities, the C3 will provide the administrative assistance, data, and training needed to help ComPASS grantees achieve their unique stated goals.

PI_NAMEs: CARROLL-SCOTT, AMY  (contact);DIEZ ROUX, ANA VICTORIA;EBERTH, JAN MARIE

PROGRAM_OFFICER_NAME: BLACHMAN, DARA

PROJECT_TERMS: Address;Adherence;Affinity;Back;Collaborations;Common Data Element;Communities;community based participatory research;community building;community engaged research;Community of Practice;community organizations;community partners;community partnership;community-centered;Community-Led Health Equity Structural Intervention;Consultations;COVID-19 pandemic;Data;Data Aggregation;Data Collection;data dashboard;data ecosystem;data platform;data resource;Data Science;Development;disability;dissemination strategy;economic outcome;Ecosystem;Education;Ensure;Ethnic Origin;Evaluation;Exclusion;experience;Faculty;FAIR principles;Faith;Feedback;flexibility;Fostering;Funding;gender minority community;Goals;group intervention;Growth;Health;health disparity populations;health equity;Health equity research;health inequalities;Housing;Immigrant;implementation intervention;Indigenous;Inequity;Infrastructure;innovation;Institution;Intervention;Intervention Studies;Investments;Lead;Leadership;leadership development;Learning;Measures;meetings;member;Methodology;multimodality;Needs Assessment;neglect;New Mexico;online repository;Outcome;Outcomes Research;peer learning;peer support;Persons;PhenX Toolkit;Pilot Projects;Play;podcast;Policies;Process;programs;Public Health Schools;Race;racial disparity;Recording of previous events;recruit;Reporting;Research;Research Methodology;Research Personnel;Research Training;Resources;Role;rural setting;Safety;scale up;science and society;Sexual and Gender Minorities;Shapes;Site;social;social health determinants;Structure;success;synergism;System;therapy design;tool;Training;Translating;Translations;Trust;Underrepresented Populations;United States National Institutes of Health;Universities;Update;urban setting;user-friendly;Vertebral column;virtual;web site;Work

PROJECT_TITLE: Advancing Health Equity Through Innovative Community Capacity Building, Data Science & Delivering Community-Centered Structural Interventions & Outcomes: Drexel's ComPASS Coordinating Center (C3)


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative. Engineering the genetic code of living organisms can achieve functions that are not available in extant living systems, 1.) including escape-free biocontainment, 2.) the prevention of horizontal gene transfer, and 3.) resistance to all natural viruses. This proposal will yield a novel technology and a bacterial host for controlled drug production that simultaneously achieve these three functions. The combination of genetic-code-based biocontainment and horizontal gene transfer prevention is expected to enable long-term, safe therapeutic applications including noninvasive drug production inside the human body, without the unwanted proliferation of such therapeutics or their genetic information outside patients.

PI_NAMEs: NYERGES, AKOS  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: addiction;Address;Advisory Committees;Amino Acids;Amino Acyl-tRNA Synthetases;Ammonia;Animal Model;Autoimmune Diseases;Bacteria;bacterial resistance;Bacteriophages;Biological Assay;Biological Products;career development;cell growth;Cell Proliferation;Cell Survival;Cells;Church;Clinical;clinical translation;Code;Codon Nucleotides;colonization resistance;Development;Development Plans;Disease;Dose;Drug Delivery Systems;Drug Kinetics;drug production;Engineering;Environment;Enzymes;Escherichia coli;Excretory function;experimental study;firewall;fitness;Food Supplements;Gastrointestinal tract structure;Gene Expression;gene function;Gene Transfer;Generations;Genes;Genetic;Genetic Code;Genetic Engineering;genetic information;Genetically Modified Organisms;Genomics;Goals;Growth;gut colonization;Half-Life;Health;Horizontal Gene Transfer;Human;Human body;in vivo;Inherited;Laboratories;Link;Lyase;Malignant Neoplasms;Mass Spectrum Analysis;medical schools;Mentors;Metabolic Diseases;microbial;microbial host;microbiome;microorganism;mouse model;Mus;new technology;next generation;novel therapeutics;Organism;Patients;peptide drug;Pharmaceutical Preparations;Phase;Predatory Behavior;prevent;Prevention;Production;programs;Proliferating;Proteomics;Research;research and development;Resistance;Risk;Role;Safety;Sense Codon;small molecule;Supplementation;synthetic biology;synthetic construct;System;Technology;Terminator Codon;Test Result;Testing;Therapeutic;therapeutic development;therapeutic enzyme;therapeutic gene;therapeutic transgene;Therapeutic Uses;Training;Transfer RNA;Transgenes;Translating;Tyrosine;Tyrosinemias;United States National Institutes of Health;unnatural amino acids;Variant;Viral;Viral Genes;viral resistance;Virus;Virus Diseases;virus host interaction;Work

PROJECT_TITLE: Development of a Gene-Transfer-Resistant and Biocontained Next-Generation Bacterial Host for Controlled Drug Delivery


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The overall purpose of this proposal is to continue to identify new strategies for cancer immunotherapy based on understanding the molecular features of the T cell-inflamed and non-T cell-inflamed tumor microenvironment. Our overall approach centers on a bi-directional work flow between patient outcomes and clinical samples, and mouse models for mechanistic understanding. Our 5-pronged research stream investigates novel T cell immune checkpoints, innate immune strategies to promote de novo T cell responses in the tumor microenvironment, tumor cell-intrinsic oncogenic events mediating immune resistance, regulation of anti-tumor immunity by the commensal microbiota, and germline variants influencing host anti-tumor T cell responses.

PI_NAMEs: GAJEWSKI, THOMAS F (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: anti-PD-1;cancer immunotherapy;CD8-Positive T-Lymphocytes;Clinic;Clinical;commensal microbes;Data;Event;FDA approved;Funding;Germ-Line Mutation;Immune;immune cell checkpoints;immune checkpoint blockade;immune resistance;Immunotherapy;Investigation;Malignant Neoplasms;Mediating;Molecular;Monoclonal Antibodies;mouse model;neoplastic cell;novel;novel therapeutic intervention;novel therapeutics;Oncogenic;patient subsets;Patient-Focused Outcomes;predicting response;Regulation;Research;Resistance;Sampling;Stream;T cell response;T-cell inflamed;T-Lymphocyte;tumor;Tumor Immunity;tumor microenvironment;Work

PROJECT_TITLE: Overcoming resistance to anti-PD1 immunotherapy


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: In this U54 partnership, UCR and CoHCCC aim to develop the collaborations, resources, and training programs to reduce disparities in drug development throughout the entire drug development pipeline. Our goal is for this program to become a focal point for UCR and CoHCCC to mentor and train a diverse force of cancer biologists and address the disparities in cancer therapeutics and drug development. Our goal is for this program to mentor and train a diverse force of cancer biologists and address the disparities in cancer therapeutics and drug development.

PI_NAMEs: MARTINEZ, ERNEST ;SEEWALDT, VICTORIA L. (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Address;Affect;African;African American;African American population;American;anti-cancer research;Award;Bioinformatics;Black race;California;Cancer Center Planning Grant;cancer health disparity;Catchment Area;Cell Line;City of Hope Comprehensive Cancer Center;Clinical;clinical trial participant;Collaborations;commercialization;Communities;Comprehensive Cancer Center;Conduct Clinical Trials;Core Facility;County;Crowding;Disparity;disparity elimination;disparity reduction;Drug Design;drug development;drug discovery;Drug Targeting;Economics;Education;Engineering;Ensure;Equity;European;Faculty;FDA approved;Fellowship;Fostering;Funding;Goals;Grant;Growth;Hispanic Americans;Incubators;Individual;Infrastructure;Institution;Investments;Joints;Laboratories;Latino;Latino Population;Los Angeles;Malignant Breast Neoplasm;Malignant Neoplasms;manufacturing facility;Master of Science;medical schools;men;Mentors;Mentorship;Minority;minority communities;Neighborhoods;news;next generation;Not Hispanic or Latino;novel therapeutics;Pharmaceutical Preparations;Phase;phase 1 testing;Physicians;Population;Population Heterogeneity;Postdoctoral Fellow;Prognosis;programs;Reporting;Research Personnel;Resources;Scientist;screening;Section 8;Site;small molecule inhibitor;Societies;Students;success;synergism;System;Testing;Therapeutic Agents;therapeutic development;Therapeutic Trials;Toxic effect;Training;Training Programs;Translations;United States;United States National Institutes of Health;Universities;women of color;Work

PROJECT_TITLE: 1/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Rural Health;Social Determinants of Health

PI_NAMEs: SEEWALDT, VICTORIA L. (contact)

PROJECT_TERMS: Address;Advocate;Antelopes;California;cancer health disparity;career;Catchment Area;Cellular biology;chimeric antigen receptor T cells;City of Hope Comprehensive Cancer Center;Clinical;Clinical Trials;Collaborations;Communication;Communities;community advisory board;Community Outreach;Comprehensive Cancer Center;County;Data;Development;Disparity;disparity elimination;diversity and inclusion;Doctor of Medicine;Doctor of Philosophy;drug development;Economics;education research;Ensure;Environment;Evaluation;experience;Farm;Fostering;frontier;Funding;Grant;Growth;health disparity;human subject protection;Incubators;Individual;Latina;Lead;Leadership;Los Angeles;meetings;member;Mentors;Mentorship;minority communities;Mission;Monitor;National Cancer Institute;Neighborhoods;New York City;next generation;outreach;Pilot Projects;Policies;Policy Developments;Politics;Principal Investigator;professor;programs;Publications;Reporting;Research;Research Personnel;Resources;rural area;Safety;Science;T cell therapy;Therapeutic;Time;timeline;Toxicology;Training;Translational Research;United States;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Administrative Core


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: Ota

ORG_COUNTRY: NIGERIA

ORG_FIPS: NI

ORG_NAME: COVENANT UNIVERSITY

PHR: PROJECT NARRATIVE Genomic information has the potential to transform health care by informing risk prediction and giving biological insights into potential treatments. However, existing genomic models have been based primarily on non-African individuals and have been based primarily on single nucleotide polymorphisms, ignoring more complex variant types. Here, we leverage innovative data analysis methods to characterize genetic variation at repetitive regions of the genome and their contribution to medically relevant phenotypes within Africa.

PI_NAMEs: GYMREK, MELISSA ;JJINGO, DAUDI ;OYELADE, JELILI OLANREWAJU (contact)

PROGRAM_OFFICER_NAME: GAO, JEAN XUEJING

PROJECT_TERMS: Address;Africa;African;Area;Bayesian Analysis;biobank;Bioinformatics;Biological;cancer risk;cardiometabolism;Chronic Kidney Failure;Clinical;cohort;Collaborations;Complex;Computational Biology;computer science;Data;Data Analyses;Data Science;Data Set;Diagnosis;Disease;disease model;disorder risk;diverse data;Exclusion;experience;Fostering;genetic variant;Genetic Variation;Genome;genome analysis;Genome Scan;genome sequencing;genome-wide;Genomic approach;genomic data;Genomics;Genotype;Goals;Haplotypes;Health;Healthcare;High Performance Computing;High Prevalence;HIV;Human;human disease;Human Genome;Huntington Disease;improved;Individual;industry partner;Infrastructure;innovation;insight;Length;Machine Learning;machine learning method;Mathematics;Medical;Meta-Analysis;Methods;Minisatellite Repeats;Modeling;novel;Outcome;Pathogenicity;Performance;Phenotype;polygenic risk score;Population;Prevalence;Repetitive Sequence;Research Personnel;risk prediction;risk prediction model;Role;Sample Size;Short Tandem Repeat;Signal Transduction;Single Nucleotide Polymorphism;SNP array;SNP genotyping;Source;Supercomputing;Tandem Repeat Sequences;Techniques;Technology;trait;Translating;Trypanosomiasis;Universities;Variant;whole genome;working group

PROJECT_TITLE: Genome-wide characterization of complex variants and their phenotypic effects in African populations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

PROJECT_TERMS: Award;Basic Science;California;Cancer Center Planning Grant;City of Hope Comprehensive Cancer Center;Clinical Trials;Collaborations;Comprehensive Cancer Center;Development;Disparity;drug development;education research;Engineering;Evaluation;experience;Funding;Genomics;Goals;Grant;Institution;Instruction;Joints;medical schools;meetings;Mentors;Mentorship;Monitor;Pharmaceutical Preparations;Pilot Projects;Qualifying;Research;Research Personnel;Resource Development;Resource Sharing;Resources;Schedule;Structure;success;Tissue Banks;translational impact;Translational Research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Core 4: Shared Resource - Capacity Development


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Women's Health Research

PI_NAMEs: JONES, VERONICA CHRISTINE (contact)

PROJECT_TERMS: Acetylation;Acylation;Affect;African ancestry;African Women;Arginine;Automobile Driving;Binding;Biological;Biological Markers;Biology;Biopsy Specimen;Breast Cancer Cell;Breast Epithelial Cells;cancer cell;cell immortalization;Cell Physiology;Cell Proliferation;cell transformation;cell type;Cells;cofactor;Complex;Data;determinants of treatment resistance;Disproportionately impacts women;drug development;druggable target;EP300 gene;Epigenetic Process;ERBB2 gene;Estrogen receptor positive;European;Gene Expression Regulation;Genes;Genetic;Genetic Transcription;Goals;Histone Acetylation;Histone H3;Histones;Human;improved;Individual;Invaded;Isomerism;Lysine;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;mammary;MCF10A cells;Metabolic Activation;Molecular;Mutation;Neoplasm Metastasis;new therapeutic target;notch protein;Oncogenic;overexpression;Pathway interactions;Peptidylprolyl Isomerase;PIK3CA gene;PIK3CG gene;Prognosis;programs;promoter;Publishing;Reader;recruit;Recurrence;Regulation;Resistance;Role;Signal Pathway;Signal Transduction;Site;stem;stem cell self renewal;Testing;Therapeutic;therapeutic target;therapy resistant;Tissue Banks;Transactivation;Transcriptional Activation;tumor;Tumor Cell Biology;Woman;Writing;XCL1 gene

PROJECT_TITLE: Project 1


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: The goal of VA's RR&D office is to maximize functional recovery. This proposal will allow us to test an intervention that combines the fundamentals of Physical Medicine and Rehabilitation with state-of-the-art nutritional support and innovations in care such as telehealth and the use of activity trackers to optimize patients before high-risk surgery. This intervention has the potential to not only reduce complications and hospital readmissions, but also to maximize functional recovery and quality of life for thousands of Veterans undergoing high-risk surgery every year. Furthermore, the proposal is the first step in the design and implementation of prehabilitative services for Veterans living in rural areas and those with inadequate support or transportation.

PI_NAMEs: BARBEITO, ATILIO  (contact)

PROJECT_TERMS: Accelerometer;Activities of Daily Living;Adherence;Adverse event;Aerobic Exercise;Anxiety;Aortic Aneurysm;automated text message;Caring;Clinical;cohort;Counseling;Country;Cystectomy;Data;design;Dietary Intervention;Elements;Enrollment;Ensure;Exercise;exercise intensity;exercise intervention;exercise program;exercise training;fitness;follow-up;functional status;Future;Goals;Habilitation;health related quality of life;Health Technology;high risk;high risk population;Home;hospital readmission;Hospitals;improved;improved outcome;innovation;Institution;interest;Intervention;Measures;Mental Depression;Monitor;multimodality;Multivitamin;muscle form;novel;nutrition;Nutritional;Nutritional status;Nutritional Support;operation;Operative Surgical Procedures;Outcome;Participant;patient oriented;Patients;Perioperative;Perioperative complication;Physical activity;Physical Fitness;Physical Function;Physical Medicine;Physical Rehabilitation;physiologic stressor;Pilot Projects;Population;Postoperative Complications;Postoperative Period;Preparation;programs;Proteins;Protocols documentation;Publishing;Quality of life;randomized trial;Recovery of Function;Rehabilitation therapy;remote delivery;repaired;Reporting;Research;Risk;rural area;Safety;Services;Socialization;Stress;Supervision;Supplementation;surgery outcome;surgical risk;System;telehealth;Testing;Text Messaging;Time;Training;Transportation;Travel;Veterans;Visit;Vitamin D supplementation;Whey Protein;Work

PROJECT_TITLE: Prehabilitation of Veterans with Exercise and Nutrition (PREVENT)

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

ORG_CITY: RIVERSIDE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PI_NAMEs: MARTINEZ, ERNEST  (contact);SEEWALDT, VICTORIA L.

PROJECT_TITLE: 2/2 Drug Development and Capacity Building: A UCR/CoH-CCC Partnership


PI_NAMEs: MARTINEZ, ERNEST  (contact)


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases

PI_NAMEs: RAOOF, MUSTAFA  (contact)

PROJECT_TERMS: African American population;African American Women;Animal Model;Apoptosis;Attention;Award;Basic Science;biophysical techniques;Biotechnology;California;cancer cell;Cancer Etiology;Cell Line;Cell model;Cells;Cessation of life;Chemoresistance;chemotherapy;City of Hope Comprehensive Cancer Center;Clinic;clinical translation;Collaborations;Comprehensive Cancer Center;Core Facility;County;Cytotoxic Chemotherapy;Data;design;Development;Doctor of Philosophy;drug development;drug discovery;Drug Kinetics;Economic Development;efficacy study;Ethnic Origin;Event;Fibroblasts;first-in-human;gemcitabine;Genetic;Immunotherapy;improved;In Vitro;Incidence;Incubators;Individual;Infrastructure;inhibitor;innovation;Institution;KRAS2 gene;Laboratories;lead optimization;Link;Malignant Breast Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mediating;Medicine;Mus;neoplastic cell;NMR Spectroscopy;novel;Nuclear;Oncogenic;Oncoproteins;overexpression;pancreatic cancer cells;pancreatic cancer model;pancreatic cell line;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient derived xenograft model;Patients;Penetration;Peptidylprolyl Isomerase;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;phase 1 testing;Phosphorylation;programmed cell death protein 1;Proline;Property;Proteins;racial population;receptor;Resistance;Resource Sharing;Resources;rural counties;Signal Transduction;Small Business Innovation Research Grant;small molecule;Structure;Survival Rate;Synthesis Chemistry;targeted agent;targeted treatment;Testing;therapeutic development;therapy resistant;Tissues;Transgenic Mice;Translating;Translations;tumor heterogeneity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Up-Regulation;uptake;X-Ray Crystallography

PROJECT_TITLE: Project 2


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Services;Prevention;Primary Health Care;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Women with chronic conditions are more likely to not use contraception and experience unplanned pregnancy, yet lack resources that address their unique contraceptive decision needs. To address this pressing public health and clinical issue, this project will evaluate a web-based contraceptive decision support tool that helps patients choose contraception in context of their chronic conditions and personal priorities. The project’s focus on contraception for a medically at-risk population is aligned with NICHD’s Strategic Plan to support people’s reproductive priorities, reduce contraceptive non-use, and improve reproductive health outcomes.

PI_NAMEs: WU, JUSTINE P (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adherence;adherence rate;adverse pregnancy outcome;Affect;aged;Anemia;arm;Awareness;Blinded;Body Weight Changes;Caring;Centers for Disease Control and Prevention (U.S.);Chronic;Chronic Disease;Clinic Visits;Clinical;clinical care;clinical decision support;Cluster randomized trial;Complex;condoms;Conflict (Psychology);Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Counseling;dalton;Data;Data Reporting;Decision Making;design;Development;digital;Disease;Education;efficacy evaluation;Enrollment;Epidemiology;evidence base;experience;Family Planning;Fatigue;Geography;Goals;Guideline Adherence;Guidelines;Health;improved;Individual;innovation;Intervention;Interview;Maternal Health;Measures;Mediating;Mediator;Medical;Methods;National Institute of Child Health and Human Development;novel;Online Systems;Outcome;Outcome Assessment;Patient Preferences;patient response;Patient Self-Report;Patients;peer;person centered;Persons;Pilot Projects;Populations at Risk;Postpartum Women;Pregnancy;Pregnancy Complications;primary care clinic;primary care practice;primary care provider;primary care setting;primary outcome;Probability;Procedures;Process;provider adherence;Psychometrics;Public Health;Published Comment;Reporting;reproductive;Reproductive Health;Research;Resources;Risk;secondary outcome;Self Management;Services;Side;Strategic Planning;support tools;Symptoms;Testing;theories;Time;tool;treatment arm;trend;Uncertainty;unintended pregnancy;Visit;web-based tool;Weight;Withdrawal;Woman

PROJECT_TITLE: Improving contraceptive decision support for individuals with chronic conditions

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


PROJECT_TERMS: Award;Basic Science;California;Cancer Center Planning Grant;City of Hope Comprehensive Cancer Center;Clinical Trials;Collaborations;Comprehensive Cancer Center;Development;Disparity;drug development;education research;Engineering;Evaluation;experience;Funding;Genomics;Goals;Grant;Institution;Instruction;Joints;medical schools;meetings;Mentors;Mentorship;Monitor;Pharmaceutical Preparations;Pilot Projects;Qualifying;Research;Research Personnel;Resource Development;Resources;Schedule;Structure;success;Tissue Banks;translational impact;Translational Research;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: Capacity Development Core


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Women's Health Research

PROJECT_TERMS: Acetyl Coenzyme A;Acetylation;African American;African ancestry;African Women;ATAC-seq;Biological Markers;Black race;Blood Vessels;Breast Cancer survivor;California;Cardiovascular Diseases;Cell Aging;Cell Separation;Cells;Chemoprevention;ChIP-seq;Chromatin;City of Hope Comprehensive Cancer Center;clinical biomarkers;Clinical Trials;Code;cohort;Collection;community center;Comprehensive Cancer Center;cytokine;Cytotoxic Chemotherapy;Data;Diabetic Nephropathy;Doctor of Medicine;drug development;drug repurposing;Eating;Epigenetic Process;Estrogen receptor negative;experience;Failure;fighting;follow-up;Gene Abnormality;Genes;Genetic Transcription;Grant;Growth;Health;Heart;Hematopoietic stem cells;Histone Acetylation;Human Resources;Hyperinsulinism;Inflammation;Inflammatory;Institutional Review Boards;Insulin;Insulin Resistance;Interferon-beta;Interleukin-6;IRF1 gene;Joints;Kidney;Latina;Latina Population;Leukocytes;Link;Malignant Breast Neoplasm;Malignant Neoplasms;medical schools;Mentors;Mentorship;Metabolic;Metformin;Mitochondria;mouse model;Muscle Cells;NF-kappa B;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;Organ;outreach;Patients;Phase;Pilot Projects;pilot trial;Premature aging syndrome;Production;Proteins;recruit;Regulation;Reproducibility;Research;Research Personnel;Respiration;Risk;Running;senescence;senescence associated secretory phenotype;senescent cell;Serum;standard of care;Supervision;Surveys;Testing;Therapeutic Trials;Time;TNF gene;Training;transcriptomics;Transplantation;Universities;White Women;Woman

PROJECT_TITLE: Pilot Project 1


PROJECT_TITLE: Full Project 1


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

PI_NAMEs: ANN, DAVID K. (contact)

PROJECT_TERMS: anti-cancer research;Award;California;cancer health disparity;career;career development;City of Hope Comprehensive Cancer Center;Clinical Trials;Collaborations;Communities;community advisory board;Comprehensive Cancer Center;Contractor;Databases;drug development;Education;Educational process of instructing;Educational workshop;Effectiveness;Equity;equity, diversity, and inclusion;Evaluation;Feedback;Funding;Future;Goals;Grant;health disparity;improved;Individual;insight;Joints;Knowledge;Leadership;Measures;meetings;Mentors;Mentorship;Modeling;Monitor;Outcome Measure;outreach;Performance;Pilot Projects;Play;Process;Program Evaluation;programs;Progress Reports;Publications;Recommendation;Reporting;Research;Research Personnel;Resources;Structure;success;Surveys;Therapeutic;Training;Training and Education;Training Programs;Translational Research;United States National Institutes of Health;Universities;webinar;Work

PROJECT_TITLE: Core 1: Planning and Evaluation


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;HPV and/or Cervical Cancer Vaccines;Immunization;Infectious Diseases;Prevention;Sexually Transmitted Infections;Vaccine Related;Women's Health Research

ORG_CITY: KIGALI

ORG_COUNTRY: RWANDA

ORG_FIPS: RW

ORG_NAME: RESEARCH FOR DEVELOPMENT

PHR: NARRATIVE Sub-Saharan Africa carries the highest burden globally of both HIV and cervical cancer. Cervical Cancer is 6-fold more common in women with HIV, and is preventable via vaccination prior to HPV exposure, or through screening and treating women for HPV infection or cervical lesions. Rwanda is a low-income country with high burden of both HIV and cervical cancer. Finding effective implementation strategies for cervical cancer in WWH can impact favorably on African women’s health.

PI_NAMEs: ANASTOS, KATHRYN M.;MURENZI, GAD  (contact);RUBAGUMYA, FIDEL

PROGRAM_OFFICER_NAME: FRECH, MARIA SILVINA

PROJECT_TERMS: 12 year old;15 year old;acceptability and feasibility;Address;Adenocarcinoma In Situ;Adherence;Africa;Africa South of the Sahara;African Women;Age;antiretroviral therapy;arm;attributable mortality;Cancer Burden;Cancer Etiology;cancer invasiveness;Central Africa;Cervical;cervical cancer prevention;Cervical Cancer Screening;Cervical Intraepithelial Neoplasia;Cervix Uteri;Cessation of life;chronic infection;Clinic;Clinical;clinical trial protocol;Clinical Trials;Clinical Trials Network;Clinical Trials Unit;clinically significant;Communities;Consultations;contextual factors;Country;Cytology;Data;Disease;Eastern Africa;Enrollment;experience;Exposure to;Genotype;girls;Government;Health;health care delivery;Healthcare;HIV;HIV Seronegativity;HPV-High Risk;Human papilloma virus infection;Human Papilloma Virus Vaccination;Human Papilloma Virus Vaccine;Human Papillomavirus;Immunization Programs;Immunocompetence;implementation evaluation;implementation science;implementation strategy;Incidence;Infection;innovation;Knowledge;Laboratories;Lesion;Location;low and middle-income countries;low income country;Malignant neoplasm of anus;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Methods;Modality;Molecular;mortality;Pathology;Performance;performance tests;Persons;Population;premalignant;prevent;Prevention program;Productivity;programs;protocol development;Protocols documentation;Research;Research Personnel;Risk;Rwanda;screening;screening program;Services;Site;Standardization;Testing;Thermal Ablation Therapy;Time;treatment program;uptake;Vaccinated;Vaccination;vaccine effectiveness;Viral Load result;virtual;virus related cancer;Visual;Western Africa;Woman;Women's Health;women's prevention;Women's study;women's treatment;Work;World Health Organization

PROJECT_TITLE: Rwanda CASCADE Clinical Trials Site for cervical cancer prevention


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Digestive Diseases;Health Disparities and Racial or Ethnic Minority Health Research;Immunotherapy;Orphan Drug;Pancreatic Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Rural Health

PI_NAMEs: PELLECCHIA, MAURIZIO  (contact)

PROJECT_TERMS: African American population;Animal Model;Apoptosis;Attention;Award;Basic Science;biophysical techniques;Biotechnology;California;cancer cell;Cancer Etiology;Cell Line;Cell model;Cells;Cessation of life;Chemoresistance;chemotherapy;Cities;City of Hope Comprehensive Cancer Center;Clinic;clinical translation;Clinical Trials;Collaborations;Comprehensive Cancer Center;Core Facility;County;Cytotoxic Chemotherapy;Data;design;Development;Doctor of Philosophy;drug development;drug discovery;Drug Kinetics;Economic Development;efficacy study;Ethnic Origin;Event;Fibroblasts;first-in-human;gemcitabine;Genetic;Goals;Immunotherapy;In Vitro;Incidence;Incubators;Individual;Infrastructure;inhibitor;innovation;Institution;KRAS2 gene;Laboratories;lead optimization;Link;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Mediating;Medicine;Mus;neoplastic cell;NMR Spectroscopy;novel;Nuclear;Oncogenic;Oncology;Oncoproteins;overexpression;pancreatic cancer cells;pancreatic cancer model;pancreatic cancer patients;pancreatic cell line;Pancreatic Ductal Adenocarcinoma;Pathway interactions;patient derived xenograft model;Patients;Penetration;Peptidylprolyl Isomerase;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;phase 1 testing;Phosphorylation;programmed cell death protein 1;Proline;Property;Proteins;racial population;receptor;Resistance;Resource Sharing;Resources;rural counties;Signal Transduction;small molecule;Structure;Survival Rate;Synthesis Chemistry;targeted agent;targeted treatment;Testing;therapeutic development;therapy resistant;Tissues;Transgenic Mice;Translating;Translations;tumor heterogeneity;tumor microenvironment;Tumor Suppressor Proteins;tumor-immune system interactions;tumorigenesis;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Up-Regulation;uptake;X-Ray Crystallography

PROJECT_TITLE: Full Project 2


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Precision Medicine;Social Determinants of Health

PI_NAMEs: TALISMAN, TIJANA  (contact)

PROJECT_TERMS: African American;American;anti-cancer research;Antineoplastic Agents;Applications Grants;Award;Basic Science;Bioinformatics;Biology;California;cancer health disparity;career;Catchment Area;chimeric antigen receptor T cells;City of Hope Comprehensive Cancer Center;Clinical;Clinical Research;Clinical Trials;commercialization;Communities;community engaged research;Comprehensive Cancer Center;Conduct Clinical Trials;Core Facility;curriculum development;Data;Development;Disparity;disparity elimination;diversity and inclusion;Drug Design;drug development;drug discovery;drug repurposing;Drug Targeting;Education;Education and Outreach;education research;Educational Activities;Educational Curriculum;Engineering;Equity;Ethics;ethnic diversity;European;experience;Faculty;first-in-human;Funding;Goals;graduate school;graduate student;Grant;Health Disparities Research;health disparity;Hispanic Americans;Hispanic-serving Institution;innovation;Interview;Investments;Joints;Laboratories;Latino;long-standing disparities;manufacturing facility;Master of Science;medical schools;Medical Students;Mentorship;Methods;minority communities;nanotherapy;NCI Center for Cancer Research;news;next generation;novel therapeutics;Participant;Pathway interactions;Patients;Pharmaceutical Preparations;Phase;Physicians;Postbaccalaureate;Postdoctoral Fellow;precision medicine;Precision Medicine Initiative;programs;Reporting;Research;research and development;Research Infrastructure;Research Personnel;Research Training;Resources;Rotation;Scientist;screening;Site;social determinants;Societies;stem cell therapy;Structure;student training;Students;success;summer research;summer student;System;targeted agent;Testing;Training;Training Programs;Translating;Translations;undergraduate student;United States;United States Food and Drug Administration;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Core 2: Research Education


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Lymphatic Research;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: PROJECT NARRATIVE Traumatic Brain Injury (TBI) affects millions of people worldwide and is a risk factor for later development of neurodegenerative diseases like Alzheimer's Disease (AD). TBI causes rapid release of the proteins amyloid and tau, which are the toxic proteins that build up in the brain in AD. Using Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI) performed as soon as possible after TBI, this project will monitor the deposition and rate of clearance of these proteins, with the goal of better understanding how brain clearance may relate to TBI recovery and later risk of neurodegeneration.

PI_NAMEs: BUTLER, TRACY A. (contact);LI, YI ;SHAH, SUDHIN

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta accumulation;Abeta clearance;abeta deposition;Acceleration;Accident and Emergency department;Acute;Affect;Aging;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Amyloid Proteins;Animal Diseases;Animal Model;Animals;Biological Markers;Blood;Blood Vessels;Brain;brain dysfunction;Cause of Death;Cerebrospinal Fluid;cerebrospinal fluid clearance;Clinical assessments;Cognition;Cognitive;comparison control;Complex;critical period;Data;Deposition;design;Development;Diffusion;disability;Disease Progression;Excision;Failure;fluid flow;Functional disorder;Functional Magnetic Resonance Imaging;Future;glymphatic clearance;glymphatic flow;glymphatic system;Goals;Hour;Human;human model;Impairment;Inflammation;Injury;insight;Intercellular Fluid;Intervention;Lesion;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measurement;Measures;Metabolic Clearance Rate;Methods;mild traumatic brain injury;misfolded protein;Modality;Modeling;Monitor;multimodality;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;novel;Outcome;Pathologic;Persons;Pharmaceutical Preparations;Phase;Positron-Emission Tomography;prevent;primary outcome;Process;Prognostic Factor;prospective;Protein Dynamics;Proteins;Publishing;radiotracer;Recovery;recruit;Reporting;Research;Risk;Risk Factors;secondary outcome;Sleep;Sleep disturbances;solute;standard measure;Symptoms;System;targeted treatment;tau Proteins;Techniques;therapeutic target;Time;Toxin;Traumatic Brain Injury;Traumatic Brain Injury recovery;Ventricular;ventricular system;wasting;water channel

PROJECT_TITLE: Brain fluid clearance and misfolded protein dynamics following traumatic brain injury

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE The Centers for Disease Control and Infection consider Clostridioides difficile infection an urgent public health threat; this career development award addresses our limited ability to predict its severe complications, response to treatment, or recurrence of disease, and to distinguish it from indolent carriage. We hypothesize that by integrating fecal immune, metabolic and microbial data, with modern bioinformatics tools, we can improve our ability to predict these situations and understand the biological mechanisms behind them. Biological markers in stool will be valuable tools to choose or design more timely and effective treatments for patients.

PI_NAMEs: VILLAFUERTE GALVEZ, JAVIER ANDRES (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Address;Admission activity;Advisory Committees;anti-toxin;Asthma;Award;Awareness;Bacteria;biobank;Bioinformatics;bioinformatics tool;Biological;Biological Markers;Biological Process;Biology;biomarker identification;biomedical informatics;Blinded;Blood;career;career development;catalyst;Categories;Centers for Disease Control and Prevention (U.S.);Cessation of life;Characteristics;Classification;Clinical;clinical predictors;Clinical Research;clinical translation;clinically relevant;Clostridium difficile;cohort;Colectomy;Colitis;Computing Methodologies;Critical Care;cytokine;Data;design;Diagnosis;Diagnostic;diagnostic algorithm;Diarrhea;Digestive System Disorders;Disease;drug development;drug quality;Educational Curriculum;effective therapy;Environment;experience;Failure;Feces;Fellowship;Focus Groups;Foundations;fungus;Gastroenterologist;Goals;Grant;Grouping;gut inflammation;gut microbiome;Human;Immune;Immune response;improved;Indolent;Infection;Inflammatory;Inflammatory Bowel Diseases;insight;instructor;Israel;K-Series Research Career Programs;Knowledge;Life;Machine Learning;machine learning algorithm;machine learning model;Mass Spectrum Analysis;Measures;Mediating;Medical center;medical schools;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Metabolic;Methodology;Methods;microbial;Modeling;Modernization;mortality risk;novel;novel therapeutics;Outcome;Parkinson Disease;pathogen;Pathway interactions;patient advocacy group;patient oriented;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pattern;Phenotype;Postdoctoral Fellow;Practice Management;predictive marker;prognostication;programs;prospective;Public Health;Quality of Care;Quality of life;recruit;Recurrence;Recurrent disease;Research;Resolution;Risk;Sampling;Severities;skills;standard of care;Stratification;Symptoms;Therapeutic;Time;tool;Training;Translational Research;treatment response;Vertebral column;Writing

PROJECT_TITLE: Redefining C.difficile patient outcomes through network medicine

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


PI_NAMEs: DAVIS, KENDRICK  (contact)

PROJECT_TITLE: Pilot-Project 1


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SISTRUNK, CHRISTOPHER M. (contact)

PROJECT_TERMS: Address;Advocate;Affect;Articulation;Awareness;Basic Science;California;cancer health disparity;City of Hope Comprehensive Cancer Center;Clinic;Clinical;clinical trial enrollment;Communities;community academic partnership;community advisory board;community engagement;Community Outreach;community partnership;community setting;Comprehensive Cancer Center;Consultations;Data;data access;Decentralization;Democracy;Disparity;Dissemination and Implementation;drug development;Education;Ensure;Environment;ethnic minority;Evaluation;evidence base;experience;Faculty;Fostering;Grant;Human;Infrastructure;innovation;Institution;Intelligence;Knowledge;Laboratories;Leadership;Malignant neoplasm of lung;Malignant Neoplasms;member;minority communities;Modeling;Outcome;outreach;Population;Process;racial minority;Recording of previous events;Research;Research Activity;Research Methodology;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Scientific Inquiry;Scientist;Services;skills;success;tool;Training;Training and Education;translational impact;translational potential;Translational Research;Translations;Universities;usability;web site;Writing

PROJECT_TITLE: Core 3: Outreach


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: ORLANDO

ORG_NAME: NEMOURS CHILDREN'S HOSPITAL, ORLANDO

ORG_STATE: FL

PHR: Project Narrative The number of pregnant women with obesity and/or gestational diabetes has increased more than 30% in the last decades producing nearly half a million infants each year in the United States alone who are born Large for Gestational Age (LGA, birthweight >90% for sex and gestational age). These infants have feeding difficulties, prolonged hospital stays and are at increased risk for future obesity. This study will evaluate the role of body composition, appetite- regulating hormones, and the implementation of a novel infant feeding strategy and its impact on length of hospital stay and short-term clinical outcomes in these at-risk infants.

PI_NAMEs: MCNELIS, KERA MICHELLE;VISWANATHAN, SREEKANTH  (contact)

PROGRAM_OFFICER_NAME: OSGANIAN, VOULA

PROJECT_TERMS: Admission activity;Age;Basal metabolic rate;Biological;Birth Rate;Birth Weight;Body Composition;Calories;Caring;Clinical;Clinical Trials;Complex;cost;Data;Desire for food;Dose;Economics;Energy Intake;Enteral Feeding;Exposure to;Family;Fatty acid glycerol esters;Feedback;feeding;Feeding behaviors;Feeds;Future;Gastrostomy;Gestational Age;Gestational Diabetes;Goals;Growth;Health Care Costs;high risk;Hormones;Hospitalization;Hunger;improved;in utero;indexing;infancy;Infant;innovation;Intake;Knowledge;Length of Stay;Life;maternal diabetes;maternal obesity;Mediating;Metabolic;Multicenter Trials;Neonatal Intensive Care Units;novel;Nutrient;Nutrition Therapy;Nutritional Support;Obesity;Oral;Outcome;Pilot Projects;precision nutrition;Pregnancy;Pregnant Women;Prevalence;prevent;prospective;Proxy;Quality of life;Randomized, Controlled Trials;Research;Research Design;response;Risk;Role;Satiation;Severities;sex;success;Time;trial comparing;Tube;United States;Weight;Weight Gain

PROJECT_TITLE: Oral Feeding Difficulty in Large for Gestational Age Infants: Defining Interrelationships between Body Composition, Oral Feeding Ability, and Appetite-Regulating Hormones

STUDY_SECTION: HSDO

STUDY_SECTION_NAME: Human Studies of Diabetes and Obesity Study Section[HSDO]


PROJECT_TITLE: Planning & Evaluation


PROJECT_TITLE: Research Education


ADMINISTERING_IC: AA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Chronic Pain;Depression;Mental Health;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Substance Misuse

ORG_CITY: REDWOOD CITY

ORG_NAME: AFASCI, INC.

PHR: 8. PROJECT NARRATIVE AfaSci is developing an FDA-accepted investigational new drug (IND) AFA-281 for alcohol use disorder. This drug can normalize neural activity and enhance the body’s anti-inflammatory ability. In our preliminary studies, AFA-281 decreased alcohol intake and preference, and suppressed alcohol-seeking behavior in rodents. We now propose to rigorously test its efficacy in animal models of alcohol use disorder to provide evidence for future clinical development of this IND into a safe and effective medication for alcohol use disorder.

PI_NAMEs: XIE, XINMIN SIMON (contact);YE, JIANG-HONG

PROGRAM_OFFICER_NAME: FALK, DANIEL EVAN

PROJECT_TERMS: Absence of pain sensation;acamprosate;Address;aged;Alcohol consumption;alcohol seeking behavior;alcohol use disorder;Alcohols;Amendment;American;Analgesics;Animal Model;animal pain;Anti-Inflammatory Agents;Anxiety;anxiety-like behavior;Area;Behavior;binge drinking;Biological Assay;Biological Availability;Brain;Canis familiaris;Cardiac;Cardiac Myocytes;Cardiotoxicity;Cells;Chronic;chronic alcohol ingestion;chronic neuropathic pain;chronic pain;Clinical;clinical development;Clinical Trials;Collaborations;comorbidity;comparison control;Darkness;Data;density;Depressed mood;deter alcohol use;Development;Disease;disease model;Disulfiram;Drug Design;Drug Kinetics;Drug Targeting;Drug usage;Electrophysiology (science);Emergency department visit;Enzymes;Epoxide hydrolase;Ethanol;Evaluation;evidence base;Exhibits;Fatty Acids;FDA approved;FOS gene;Future;glial activation;Habenula;Half-Life;Health;healthy volunteer;Human;Hyperalgesia;Hypersensitivity;Inflammation;Inflammation Mediators;inflammatory pain;inhibitor;innovation;Investigation;Investigational Drugs;Investigational New Drug Application;Ion Channel;Lateral;Lead;lead optimization;Legal patent;Ligand Binding;Mechanics;Medical;Mental Depression;Microglia;Mood Disorders;Mus;Naltrexone;negative affect;nerve injury;neural;neuroinflammation;Neurons;non-opioid analgesic;novel;Opiate Addiction;Oral;Organ;overdose death;Pain;Pain Disorder;pain model;painful neuropathy;patch clamp;Penetration;Peripheral;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Pharmacology Study;Phase;Phase I Clinical Trials;pre-clinical;preference;Public Health;Rattus;receptor;response;reward circuitry;Rewards;Rodent;Safety;screening;Self Administration;Series;side effect;Small Business Innovation Research Grant;spared nerve;Substance Use Disorder;success;Sucrose;Surveys;Symptoms;T-Type Calcium Channels;Testing;Therapeutic;Toxic effect;Toxicology;Translating;Universities;Withdrawal

PROJECT_TITLE: Development of a Novel Medication for Alcohol Use Disorder with an Active IND Dual Inhibitor of T-Type Calcium Channel and Soluble Epoxide Hydrolase


PI_NAMEs: LO, DAVID D (contact)

PROJECT_TITLE: Outreach


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Immunotherapy;Lymphatic Research;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Cancer immunotherapies have led to major treatment breakthroughs for a number of different cancers, but the majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. We have demonstrated that targeting tumors with stereotactic radiation in combination with immunotherapy while sparing draining lymphatics enhances anticancer immunity, resulting in significantly improved response profiles. The research outlined in this proposal will leverage targeted tumor radiation in combination with optimized immunotherapy in a particularly lethal form of head and neck cancer to improve clinical outcomes for both tumor control and treatment toxicity, using both animal models of head and neck cancer as well as data from clinical trials of combination targeted radiation and immunotherapy.

PI_NAMEs: CALIFANO, JOSEPH A (contact);SHARABI, ANDREW B.

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Ablation;Agonist;Animal Model;anti-cancer;Anti-CD47;anti-tumor immune response;Antigen Presentation;Antigen-Presenting Cells;Antitumor Response;Architecture;B-Lymphocytes;cancer immunotherapy;Carcinogens;CD4 Positive T Lymphocytes;CD47 gene;CD8B1 gene;cell type;Cells;chemoradiation;chemotherapy;Clinical;Clinical Data;Clinical Trials;combinatorial;conventional therapy;curative treatments;cytokine;cytotoxic;Data;Death Rate;Dendritic Cells;design;draining lymph node;Eating;effector T cell;Ethanol;Excision;Head and Neck Cancer;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;HPV-negative head and neck cancer;Human Papillomavirus;Immune;Immune checkpoint inhibitor;Immune response;Immunologic Surveillance;Immunologics;Immunotherapy;improved;improved outcome;In complete remission;inhibitor;insight;Investigation;irradiation;Localized Disease;lymph nodes;Lymphatic;lymphatic vessel;Malignant Neoplasms;Metastatic/Recurrent;Modeling;Morbidity - disease rate;mouse model;Neoadjuvant Therapy;neoplastic cell;Nivolumab;Nodal;novel;Oncogenic;Operative Surgical Procedures;Outcome;Pathologic;Patients;Phagocytosis;Phase;phase I trial;phase III trial;Phenotype;preservation;Primary Neoplasm;programmed cell death protein 1;Radiation;Radiation therapy;Radioimmunotherapy;Regional Disease;Research;response;Role;Sentinel Lymph Node;Signal Transduction;Solid Neoplasm;T cell clonality;T-Cell Activation;T-Lymphocyte;Therapeutic;Tobacco;Toll-like receptors;trafficking;treatment optimization;Treatment-related toxicity;tumor;Tumor Antigens;Tumor Immunity;tumor-immune system interactions

PROJECT_TITLE: Optimizing immunoradiotherapy for HNSCC

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Rheumatoid arthritis (RA) is a disease that affects the joints and is characterized by chronic inflammation, cartilage and bone damage that and can lead to permanent disability. We are studying how a type of white blood cell (CD8 T cell) and a protein called a granzyme can activate an inflammatory pathway (called the complement pathway) which drives inflammation and joint damage. Defining this new pathway would reveal new targets for drug development to treat RA.

PI_NAMEs: BRENNER, MICHAEL B. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Address;Affect;Affinity;Anaphylatoxins;Apoptosis;Arthritis;Automobile Driving;Binding;bone;Cartilage;Caspase;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Degranulation;Cell membrane;Cell surface;cell type;Cells;Charge;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Collagen Arthritis;Complement;Complement 3 Convertase;Complement 3a;Complement 3b;Complement 4b;Complement 5a;Complement Activation;complement C2a;complement C5b;Complement component C1s;Complement Factor D;Complement Membrane Attack Complex;complement pathway;Complement Receptor;Cytotoxic T-Lymphocytes;Deposition;Disease;drug development;Electrostatics;Elements;Fibroblasts;FRAP1 gene;Generations;Glycosaminoglycans;Granzyme;Human;immunopathology;in vivo;Inflammation;Inflammatory;Inflammatory Arthritis;insight;joint inflammation;joint injury;Joints;Lectin;Leukocytes;Lifelong disability;Lymphocyte;MASP2 gene;mast cell;Mediating;Membrane;Metabolic;Metabolic Activation;Modeling;mouse model;Mus;new therapeutic target;Organoids;Pathology;Pathway interactions;Play;Process;Production;Protein Secretion;Proteins;Publishing;Recombinants;Research;response;Rheumatoid Arthritis;Role;Serine Protease;Serum;Source;Surface;Synovial joint;Synovial Membrane;Synovitis;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Tissues;TNF gene;Work

PROJECT_TITLE: CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Although there are few racial/ethnic and income-based differences in men’s fertility intentions, Black, Latino and low-income men are more likely to be involved in unwanted pregnancies and less likely to rely on vasectomy than White and higher income men. These differences have persisted in the US for decades, and there have been few efforts to comprehensively assess the individual demand and healthcare supply-side factors underlying these uneven patterns of vasectomy use. By developing and testing a vasectomy decision support tool and prospectively assessing men’s vasectomy-related health care navigation, the proposed study seeks to identify potential strategies to facilitate timely access to desired vasectomy services to ensure that all men, regardless of race/ethnicity and income, can make informed reproductive healthcare decisions.

PI_NAMEs: BORRERO, SONYA B. (contact);WHITE, KARI L

PROJECT_TERMS: Address;Affect;Age;Age Years;Black race;Caring;Child;cognitive interview;Communities;Conflict (Psychology);Consultations;Contraceptive Agents;Contraceptive methods;Contraceptive Usage;Control Groups;Data;Decision Aid;Decision Making;design;differences in access;Disparity;Disparity population;Ecosystem;Ensure;Equity;ethnic minority;Ethnic Origin;experience;Family Planning;Female Sterilization;Fertility;follow-up;Funding;gender equity;Goals;health equity;Health Services Accessibility;Health system;Healthcare;High-Income Populations;improved;Income;Individual;innovation;interest;Intervention;Interview;Knowledge;Latino;Low income;male;Male Contraceptive Agents;medically underserved;men;men of color;Methods;multidisciplinary;National Institute on Minority Health and Health Disparities;novel;novel strategies;Online Systems;Outcome;Pathway interactions;Patients;Pattern;person centered;Persons;Postpartum Period;Poverty;Pregnancy;Pregnant Women;Prenatal care;Prevalence;prevent;primary outcome;Procedures;prospective;Race;racial minority;Randomized;Randomized, Controlled Trials;Reporting;reproductive;Reproductive Health;Research;Risk;risk perception;Sampling;secondary outcome;Services;Sex Functioning;Shapes;Side;Spanish/English;Sterilization;support tools;Surveys;Testing;Time;tool;United States;Unwanted pregnancy;Vasectomy;Visit;web based decision aid;Woman;Work

PROJECT_TITLE: Addressing factors related to disparities in vasectomy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetic Testing;Genetics;Human Genome;Infectious Diseases;Kidney Disease;Patient Safety;Pediatric;Precision Medicine;Prevention

ORG_DEPT: PEDIATRICS

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Why do children, who have not suffered the illnesses of time, need support in the pediatric intensive care unit? In this study, we will use next-generation sequencing to assess monogenic (i.e., single gene) and polygenic (i.e., many gene) risk for disease and abnormal medication response for critically ill children. The results of this study have the potential to change the clinical management of children with critical illness, shed light onto the biologic basis of disease, and drive novel therapeutic development.

PI_NAMEs: MOTELOW, JOSHUA ETHAN (contact)

PROGRAM_OFFICER_NAME: KULCHAK RAHM, ALANNA LEE

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Adverse drug event;Asthma;Biological;career development;Caring;Child;Childhood;Chronic Kidney Failure;Clinical;Clinical Management;clinical risk;Clinical stratification;Clinical Trials;clinically actionable;cohort;comparative efficacy;comparison control;congenital immunodeficiency;Critical Care;Critical Illness;Critically ill children;Data;Databases;Disease;disorder risk;Doctor of Philosophy;Dose;Early Intervention;Enrollment;Environment;Equity;ethical, legal, and social implication;exome;exome sequencing;experimental study;Fellowship;Future;gene network;Genes;Genetic;genetic association;Genetic Risk;Genetics and Medicine;Genome;genome sequencing;Genomics;Goals;Heterogeneity;Human Genetics;Hypersensitivity;improved;innovation;Intervention;Kidney;Lead;Light;loss of function;Lower Respiratory Tract Infection;Mediating;Medical center;medication administration;Medicine;Mendelian disorder;Mentors;Mentorship;Methods;Morbidity - disease rate;Network-based;Neurosciences;next generation sequencing;novel;novel therapeutics;Oranges;Pathway interactions;Patients;Pediatric Intensive Care Units;Pharmaceutical Preparations;Pharmacogenomics;Phenotype;Physicians;polygenic risk score;Positioning Attribute;Postdoctoral Fellow;precision medicine;Predisposition;programs;Proteins;Publishing;Research;Resources;Respiratory Failure;response;Risk;Risk Factors;risk variant;Sample Size;Sampling;Scientist;Secondary to;Source;targeted treatment;Testing;therapeutic development;Time;Training;Universities;Variant;venous thromboembolism;Viral;Virus Diseases

PROJECT_TITLE: Genetic Risk Underlying Pediatric Critical Illness

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative MorPhiC consortium will deliver rich resources of molecular and cellular phenotypes before and after gene knockout using in vitro cellular systems. We will develop statistical methods to combine MorPhiC resources and omic data in human phenotype studies to infer gene functions in diverse settings and identify potential causal genes of human phenotypes. Our methods pave the way to use MorPhiC resources to study the impact of gene loss on complex phenotypes.

PI_NAMEs: HSU, LI ;SHOJAIE, ALI ;SUN, WEI  (contact)

PROJECT_TERMS: Address;Alleles;Area Under Curve;Biological;Catalogs;causal variant;Cell model;cell type;Cells;Chromatin;Classification;Collaborations;Communication;Communities;Community Outreach;Complex;computer framework;Computer software;Computing Methodologies;Data;Data Analyses;data resource;deep learning;design;Disease;Drug Targeting;Educational workshop;effectiveness measure;Epigenetic Process;experience;Feedback;flexibility;Future;Gene Combinations;Gene Expression;gene function;gene interaction;gene network;gene regulatory network;Genes;genome-wide;Goals;Graph;Harvest;Human;Human Biology;Human Development;improved;In Vitro;in vivo;Individual;insight;Intervention;Knock-out;knockout gene;Learning;Medicine;member;Methods;Modeling;Molecular;molecular phenotype;Multiomic Data;multiple omics;Names;Noise;novel strategies;open source;Outcome;Output;Phase;Phenotype;Production;protein protein interaction;Research Design;Research Project Grants;research study;Resources;Signal Transduction;Signaling Molecule;Signaling Protein;Statistical Methods;Structure;System;Tissues;Validation;Variant;webinar;Work

PROJECT_TITLE: Statistical Methods for Inferring Gene-Phenotype Associations Using Omic Data from Gene Knockout and Human Phenotype Studies


NIH_SPENDING_CATS: Aging;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Services;Patient Safety

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Virtually all U.S. adults will develop multimorbidity – coexistence of multiple chronic conditions – by late adulthood, resulting in poor health outcomes and exponential increases in healthcare utilization, cost, and treatment burden as multimorbidity progresses. To improve the care of patients with multimorbidity, clinicians and investigators need effective, systematic, patient-centered tools that measure prevalent and impactful diseases weighted to patient-prioritized outcomes broadly applicable for diverse community-dwelling adults. This research will yield a new, validated, patient-centered multimorbidity index for electronic health record (EHR) data that is readily available and scalable to help guide clinical decisions, population-health management, policy, and research to improve the health outcomes and quality of care for diverse, vulnerable aging adults across the lifespan with multimorbidity – all NIA priorities.

PI_NAMEs: WEI, MELISSA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute;Adult;Advisory Committees;Affect;Age;Age Years;Aging;Algorithms;Biological Markers;burden of illness;California;Censuses;Chronic;Clinical;clinical care;clinically relevant;Code;cohort;Communities;comorbidity;cost;COVID-19;COVID-19 mortality;COVID-19 prognosis;Data;Data Linkages;Data Set;Development;disability;Disease;effective intervention;electronic health data;Electronic Health Record;epidemiology study;Equipment and supply inventories;Ethnic Origin;frailty;functional status;Future;General Population;Goals;Guidelines;Health;health care service utilization;health data;health management;Health Policy;health related quality of life;Health system;Hospitalization;human old age (65+);Immunization;improved;improved outcome;indexing;interest;Intervention;Life Cycle Stages;life span;Link;Measurement;Measures;Methods;Modeling;mortality;mortality risk;multiple chronic conditions;older adult;Outcome;Patient Care;patient oriented;Patients;Phenotype;Physical Function;Policies;Policy Maker;Polypharmacy;poor health outcome;Population;population health;Population Heterogeneity;Population Policies;Quality of Care;Race;Recommendation;Research;Research Personnel;Resource Allocation;Risk;Risk Adjustment;risk stratification;severe COVID-19;sex;shared decision making;social deprivation;Standardization;Surveys;Testing;tool;unvaccinated;Vaccinated;Vaccines;Validation;virtual;Weight

PROJECT_TITLE: New EHR-based multimorbidity index for diverse populations across the lifespan: development, validation, and application

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-P(90)S]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

PHR: Project Narrative The proposed RM1 grant will enhance the measurement, quality, and equity of care delivered in 20 community opioid treatment programs (OTPs) by co-designing and implementing measurement-based care (MBC) tools and systems. Using a Hybrid Implementation Effectiveness Type II trial with a stepped-wedge design, we will simultaneously evaluate MBC implementation (e.g., fidelity) and clinical (e.g., patient retention, improved quality of life) effectiveness. This significant and innovative study will provide: (1) critical preliminary evidence regarding the role and significance of capitalizing on MBC in opioid use disorder (OUD) interventions (including evidence on potential mechanisms underlying MBC’s effects); (2) enhanced implementation of a sustainable, equitable, and effective MBC intervention via implementation strategies that are co-designed with stakeholders (policymaker, payer, and OTP), including paperwork reduction strategies as a means to enhance capacity; and (3) alternative avenues to potentially enhance symptom-related outcomes and treatment retention of OUD interventions with downstream societal, psychological, and public health benefits.

PI_NAMEs: ALDRIDGE, ARNIE PAUL;CLOUTIER, RENEE M (contact);SCOTT, KELLI

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;Address;Alcohols;behavioral health;care systems;Caring;Charge;Clinical;Clinical effectiveness;Collection;Communication;Communities;Community Health;Community Healthcare;community partners;Complex;Contract Services;Data;Data Analytics;Data Collection;data dashboard;Data Sources;Death Rate;design;Diagnosis;Disease remission;Documentation;Dropout;Effectiveness;effectiveness/implementation hybrid;effectiveness/implementation trial;Environment;Equity;Evaluation;Evidence based intervention;Evidence based treatment;Face;Fostering;Goals;Grant;healing;Health Benefit;health organization;Health Services;Health Services Accessibility;Human;Hybrids;implementation strategy;implementation tool;Improve Access;improved;Individual;Informatics;Infrastructure;innovation;Intervention;Lead;Leadership;learning network;Literature;Measurement;Measures;medical schools;medication for opioid use disorder;meetings;Mental disorders;Mental Health;operation;Opioid;opioid treatment program;opioid use disorder;Outcome;overdose death;Patient Care;Patient Monitoring;patient retention;Patient-Focused Outcomes;Patients;Pennsylvania;Pharmaceutical Preparations;Policy Maker;Program Evaluation;programs;Protocols documentation;Provider;Public Health;Quality of life;Recovery;Reporting;Research;Research Project Grants;Risk;Role;Services;Site;Substance abuse problem;substance use;Symptoms;System;Testing;Time;tool;Training;Universities

PROJECT_TITLE: HEALing Measurement Center: Enhancing Opioid Use Disorder Recovery through Measurement Based Care


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE We will develop efficient computational tools to detect base modifications in DNA and RNA molecules, through analysis of ionic signals generated from the Nanopore sequencer. We will also validate these tools on cancer samples and cell lines. These novel methods and the computational toolbox for DNA/RNA modification detection will facilitate our understanding of the human epigenome and epitranscriptome.

PI_NAMEs: WANG, KAI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, STEPHANIE A

PROJECT_TERMS: Acceleration;Address;Affect;analog;base;Base Pairing;Benchmarking;Bioinformatics;Biological Assay;Biological Process;bisulfite;bisulfite sequencing;Bromodeoxyuridine;Cell Line;Cells;Chemicals;Classification;Clinical;clinical diagnostics;Communities;Community Developments;Complex;computational pipelines;computerized tools;cost;Data;Data Set;Dedications;deep neural network;Deoxycytidine;Detection;Development;DNA;DNA Methylation;DNA methylation profiling;DNA Modification Process;DNA sequencing;Enzymes;Epigenetic Process;epigenetic regulation;epigenome;epitranscriptome;epitranscriptomics;Future;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genomic biomarker;Genomics;Guppy;Human;human disease;Human Genome;Human Herpesvirus 8;Immunoprecipitation;improved;In Vitro;Infection;inhibitor;insertion/deletion mutation;knock-down;Knock-out;Knowledge;Machine Learning;Malignant Neoplasms;Measurable;Messenger RNA;method development;Methods;Methylation;Modeling;Modification;mRNA sequencing;multithreading;Mus;nanopore;Natural Language Processing;Neural Network Simulation;novel;Performance;Pharmaceutical Preparations;Play;pre-trained transformer;Procedures;Pythons;Quality Control;rapid technique;Reader;Repetitive Sequence;Research Personnel;Resources;RNA;RNA methylation;RNA Stability;Role;Running;Sampling;Sequence Analysis;signal processing;Signal Transduction;Single-Stranded DNA;Specific qualifier value;statistics;stoichiometry;success;tool;transcriptome;transcriptome sequencing;Translating;Translations;United States National Institutes of Health;Validation;Variant;vector

PROJECT_TITLE: Novel bioinformatics methods to detect DNA and RNA modifications using Nanopore long-read sequencing

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: CHARLESTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Alcohol use disorder (AUD) is characterized by a lack of behavioral inhibition, leading to uncontrolled and excessive alcohol consumption. This project tests the hypothesis that chronic alcohol exposure leads to critical adaptations in a thalamostriatal behavioral inhibition circuit, releasing the brake on alcohol seeking and use even in the face of behavioral suppressors. Understanding how chronic alcohol exposure alters the complex integration of information in this crucial reward circuitry will help to identify key targets for therapeutic exploration.

PI_NAMEs: OTIS, JAMES M;RINKER, JENNIFER ANNE (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Acute;Alcohol consumption;Alcohol dependence;alcohol effect;alcohol exposure;alcohol relapse;alcohol research;alcohol seeking behavior;alcohol use disorder;Alcohols;Behavior;behavior test;Behavioral;Behavioral Assay;Behavioral inhibition;Brain;Calcium;Characteristics;Chronic;Collaborations;Complex;Consummatory Behavior;Consumption;Dangerousness;Data;Dependence;Development;Dopamine Receptor;Economics;Electrophysiology (science);Ethanol;Etiology;experimental study;Fright;Genetic;Glutamates;Head;Health;Heavy Drinking;Image;Individual;insight;Interneurons;Knowledge;Laboratories;Learning;Literature;maladaptive behavior;Measures;Modeling;motivated behavior;Mus;neural;neural circuit;neuronal circuitry;Neurons;Neurophysiology - biologic function;novel;Nucleus Accumbens;Odors;optogenetics;Parvalbumins;patch clamp;Physiology;prevent;Quinine;Reporter;reward circuitry;Rewards;Role;Safety;Self Administration;Shapes;Slice;social;Stimulus;stressor;Structure of paraventricular nucleus of thalamus;Sucrose;Synapses;targeted treatment;Testing;Thalamic structure;Time;two-photon;vapor;Work

PROJECT_TITLE: Loss of Inhibitory Control in Alcohol Seeking and Dependence: Role of Thalamostriatal Circuitry

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: HYATTSVILLE

ORG_NAME: MEDSTAR HEALTH RESEARCH INSTITUTE

ORG_STATE: MD

PHR: Narrative The overarching goal of this project is to test the impact of health equity-focused navigation support for colorectal cancer screening on reducing disparity gaps across primary care clinics serving a racial and ethnically diverse population using a stepped wedged, randomized trial. We anticipate that tailoring navigation implementation and documenting contextual adaptations will lead to lower disparity gaps in colorectal cancer screening and will provide patient, clinic, and health care system feedback on how such programs can promote health equity.

PI_NAMEs: AREM, HANNAH  (contact)

PROGRAM_OFFICER_NAME: COA, KISHA

PROJECT_TITLE: Bridging the gap: Delivering Equitable Colorectal Cancer Screening


ORG_CITY: FARMINGTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE Obstetric Life SupportTM (OBLSTM) is a validated simulation curriculum to train health care workers (HCWs) across the chain of survival on preventing, recognizing, and managing maternal medical emergencies. This project will evaluate implementation of OBLSTM in a regionalized perinatal health system in Arizona, leveraging public-private partnerships to target HCWs in hospital, freestanding birthing center, and prehospital contexts, and especially those serving maternity care deserts and other marginalized communities. Findings will be used to promote national scale-up of this important health care innovation with the goal of improving patient safety and reducing inequities in maternal morbidity and mortality.

PI_NAMEs: CUNNINGHAM, SHAYNA ;SHIELDS, ANDREA DENISE (contact)

PROGRAM_OFFICER_NAME: FREEMAN, WILLIAM

PROJECT_TITLE: Implementation of a Maternal Resuscitation Curriculum in a Regionalized Perinatal Health System: Maximizing the Chain of Survival to Reduce Maternal Health Inequities


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Breast Cancer;Cancer;Gene Therapy;Genetics;Immunotherapy;Neurosciences;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE  Breast cancer brain metastasis (BCBM) is associated with deadly outcomes due to limited therapeutic options and poor response, urgently calling for the development of novel therapeutic intervention strategies. We have found that oncolytic herpes simplex virus-1 (oHSV) therapy induces neutrophil infiltration and neutrophil extracellular trap (NET) formation through induction of Insulin-like growth factor-2 (IGF2) expression and secretion into tumor microenvironment (TME), hampering therapeutic efficacy of oHSV. In this proposed research, we will uncover the mechanistic relationship between oHSV-induced IGF2 and oHSV-triggered neutrophil infiltration and NET in BCBM, and characterize the preclinical therapeutic impact of novel IGF2- scavenging oHSV in combination with radiation therapy as well as NET-mitigating oHSV for significant advance of BCBM treatment in the future clinical application.

PI_NAMEs: YOO, JI YOUNG  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Acceleration;Actins;Acyclovir;Address;advanced breast cancer;anti-tumor immune response;Anti-viral resistance;Breast Cancer Patient;cancer cell;Cancer Patient;cancer type;Clinical;clinical application;Clinical Data;Complex;cytotoxic;Development;Diagnostic Imaging;extracellular;FDA approved;Future;Generations;Glioblastoma;Goals;Hyperactivity;Immune Evasion;Immunity;immunotherapeutic virotherapy;Immunotherapy;improved;In Vitro;in vivo;Incidence;Infiltration;Inflammatory;inhibitor;Injectable;Insulin-Like Growth Factor II;Intervention;Japan;Lymphocyte;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Melanoma;Metastatic malignant neoplasm to brain;Microglia;Modality;Modeling;Mus;neoplastic cell;neutrophil;Neutrophil Infiltration;novel;novel therapeutic intervention;oncolytic herpes simplex virus;Outcome;Patients;pre-clinical;pre-clinical assessment;preclinical efficacy;prevent;Quality of life;Radiation therapy;Research;Resistance;resistance mechanism;response;Role;Safety;Signal Pathway;Survival Rate;synergism;Systemic Therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Translations;Treatment Efficacy;tumor;tumor heterogeneity;Tumor Immunity;tumor microenvironment;tumor progression;tumor-immune system interactions;Viral;Virotherapy;Virus;Virus Replication

PROJECT_TITLE: Enhanced Viro-Immunotherapy for Breast Cancer Brain Metastasis

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because a noninvasive MRI-based quantitative tool for measuring cerebral metabolism can be used to monitor patients longitudinally, both clinically and in Alzheimer's disease clinical trials. The advantages of MRI over PET include improved spatial resolution, decreased cost, increased availability, and noninvasive imaging technique, specifically not requiring injection of a radioactive tracer. This research is relevant to the NIA's mission to support research to improve the health and well- being of older people.

PI_NAMEs: CHIANG, GLORIA CHIA-YI;WANG, YI  (contact)

PROJECT_TERMS: abeta deposition;Age;aged;Alzheimer disease screening;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid beta-Protein;Apolipoprotein E;arterial spin labeling;Assessment tool;Astrocytes;Biological Markers;blood oxygen level dependent;Cerebrovascular Circulation;Cerebrum;Clinical;Clinical Trials;Cognitive;cognitive testing;computerized data processing;cost;Data;data acquisition;Dementia;denoising;Deposition;Diagnosis;Disease Progression;efficacy evaluation;Enrollment;Fingerprint;fluorodeoxyglucose;fluorodeoxyglucose positron emission tomography;follow-up;Glucose;glucose uptake;Glycolysis;gray matter;Half-Life;Health;Image;Imaging Device;imaging study;Imaging Techniques;Impaired cognition;Impairment;improved;Injections;insight;Iron;Learning;Magnetic Resonance Imaging;Magnetism;Maps;Measures;Metabolic;Metabolic dysfunction;metabolic imaging;metabolic rate;Metabolism;Microglia;mild cognitive impairment;Mission;Mitochondria;Modeling;Monitor;Nerve Degeneration;Neurofibrillary Tangles;neuronal metabolism;Neurons;Noise;non-invasive imaging;novel;Older Population;Outcomes Research;Oxidative Phosphorylation;Oxygen;Patient Monitoring;Patients;Pattern;Personal Satisfaction;Phase;Plasma;Positron-Emission Tomography;Predisposition;Preparation;Process;Property;prospective;Public Health;Radioactive Tracers;Radiochemistry;radioligand;reconstruction;recruit;Research;Research Support;Resolution;Senile Plaques;sex;Signal Transduction;Site;Speed;Staging;standard of care;Techniques;Testing;Therapeutic Trials;Tissues;tool;treatment response;Work

PROJECT_TITLE: Quantitative MRI-based cerebral oxygen metabolism in Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Physical Activity;Prevention

ORG_CITY: CHICAGO

ORG_NAME: LURIE CHILDREN'S HOSPITAL OF CHICAGO

PHR: PROJECT NARRATIVE Consumer-grade wearable devices, such as the Fitbit, are popular gadgets that also objectively measure physical activity, sleep and heart rate, and can transmit their data in near-real time. We investigate the Fitbit as a clinical tool to objectively assess recovery after pediatric appendectomy, the most prevalent inpatient pediatric surgical procedure in the US, and apply machine learning approaches to the Fitbit data for early detection of infection. We also investigate the effect of the availability of Fitbit-based alerts for infection in near- real time on clinical decision making, time to first contact with the healthcare system, and healthcare utilization patterns.

PI_NAMEs: ABDULLAH, FIZAN  (contact);GHOMRAWI, HASSAN ;JAYARAMAN, ARUN

PROGRAM_OFFICER_NAME: GIVENS-BRADLEY, SHANNON SHAREE

PROJECT_TERMS: 18 year old;Abdominal Pain;Abscess;Academic Medical Centers;adverse outcome;Algorithms;Appendectomy;Appendicitis;care seeking;Caregivers;Caring;Chicago;Child;Childhood;Clinical;clinical care;clinical decision-making;cloud based;Community Hospitals;cost;Critical Incident Technic;dashboard;Data;data dashboard;data exchange;Decision Making;Desire for food;Development;Diagnosis;Disparity;Early Diagnosis;Early identification;Electronic Health Record;Emergency Care;Emergency department visit;Emergency Situation;Feeds;Fever;fitbit;health care service utilization;Health system;Healthcare;Healthcare Systems;Heart Rate;heart rate monitor;hospital readmission;Hospitalization;Hospitals;improved;Infection;Inpatients;Intervention;Intra-abdominal;Machine Learning;machine learning algorithm;machine learning method;Measures;Methods;Monitor;non-invasive monitor;operation;Operative Surgical Procedures;Organ;Pain;parental monitoring;Parents;Patient Monitoring;patient population;Patients;Pattern;Pediatric Hospitals;Pediatric Surgical Procedures;Perforation;Phlegmon;Physical activity;Physiological;Postoperative Period;postoperative recovery;prediction algorithm;Procedures;prospective;Proxy;Recommendation;Recovery;recruit;remote patient monitoring;Reporting;Research Priority;Resources;sensor;Signal Transduction;Sleep;Sleep disturbances;Surgeon;Surgical Wound Infection;symptom science;System;Technology;tertiary care;Thermometers;Time;tool;transmission process;University Hospitals;uptake;Validation;Visit;wasting;wearable data;wearable device;Work

PROJECT_TITLE: Using the Fitbit for early detection of Infection and reduction of healthcare utilization after Discharge in Pediatric Surgical Patients

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Pediatric;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE In the United States, deaths related to pregnancy have more than doubled over the last twenty years, with an additional rise after the COVID-19 pandemic. To address these alarming trends, we designed a program that delivers care to mothers and infants together and provides multiple types of support during the year after pregnancy – the Multi-modal Maternal Infant Perinatal Outpatient Delivery System (MOMI PODS). In this trial, we’ll determine if MOMI PODS improves heart, metabolic, and mental health among new mothers and study how this may occur and how we can improve the program to better meet patient and family needs.

PI_NAMEs: BRILL, SEULI MOUSHUMI BOSE;GILLESPIE, SHANNON L. (contact)

PROGRAM_OFFICER_NAME: MCNAMARA, KAREN MARIE

PROJECT_TERMS: acceptability and feasibility;Address;Affect;anxiety symptoms;biopsychosocial;Birth;cardiometabolism;care delivery;Caring;Cessation of life;chronic care model;Clinical;clinical care;Collaborations;Country;COVID-19 pandemic;Data;Death Rate;depressive symptoms;design;Developed Countries;Discipline of obstetrics;Discrimination;Disparity;disparity reduction;effectiveness evaluation;Emergency Situation;Endocrine;Equity;ethnic disparity;ethnic minority;evidence base;evidence based guidelines;Exhibits;Expectancy;Family;Goals;health care settings;Healthcare;Heart;High-Risk Pregnancy;hospital readmission;Hospitals;Hybrids;Immune;improved;Individual;individual patient;Infant;Infant Care;Life;Link;low socioeconomic status;Maternal Health;Maternal Health Services;Medicaid;Mental Health;Metabolic;Minority;minority patient;Modality;Modeling;mortality;mortality disparity;mortality risk;Mothers;multimodality;Not Hispanic or Latino;novel;Ohio;Outcome;Outpatients;participant enrollment;Patients;Perinatal;post pregnancy;post-pandemic;postpartum care;postpartum health;Postpartum Period;Precipitating Factors;Pregnancy;Pregnancy Rate;Primary Care;primary outcome;programs;Provider;psychosocial;Psychosocial Stress;racial disparity;racial minority;racism;Randomized, Controlled Trials;Recording of previous events;reduce symptoms;Reporting;Risk;Risk Factors;Sampling;scale up;secondary outcome;Services;Site;socioeconomic disparity;Socioeconomic Status;Stress;Supportive care;System;Testing;Time;treatment as usual;trend;United States;Visit;White Women

PROJECT_TITLE: Evaluating a multi-modal maternal infant perinatal outpatient delivery system: A randomized controlled trial (MOMI PODS RCT)


NIH_SPENDING_CATS: Cannabinoid Research;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Natural Products;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: The impact of cannabis use on HIV infection and the latent reservoir is poorly understood, particularly for solid tissues such as the brain. We propose to establish a robust humanized mouse model of cannabis use and HIV infection with human microglia. We will use this model to understand how cannabis exposure impacts the size, transcriptional activity and phenotype of the brain HIV reservoir during therapy.

PI_NAMEs: BROWNE, EDWARD P (contact);GARCIA-MARTINEZ, J. VICTOR

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Acute;Address;Affect;Agonist;Animal Model;Anti-Inflammatory Agents;antiretroviral therapy;Biological Assay;Biology;Blood;Brain;brain tissue;cannabinoid receptor;Cannabinoids;Cannabis;CD4 Positive T Lymphocytes;Cells;Characteristics;Chronic;Clinical;cytokine;Data;Dose;Effector Cell;Event;exhaustion;Exhibits;Exposure to;Genetic Transcription;Goals;Heterogeneity;HIV;HIV Infections;Homeostasis;Human;human data;human tissue;humanized mouse;Immune;Immune response;Immune system;Immunity;Immunologic Markers;Immunologics;immunoregulation;in vivo;Individual;Infection;Inflammation;Inflammatory;innovation;insight;latent HIV reservoir;Learning;longitudinal human study;Maintenance;marijuana use;marijuana user;Mediating;Methods;Microglia;Modeling;Molecular;molecular phenotype;mouse model;Mus;Natural Killer Cells;neuroprotection;NF-kappa B;novel;Outcome;Participant;Pathway interactions;Peripheral;peripheral blood;Persons;Phase;Phenotype;polysubstance use;Population;reconstitution;Research;senescence;Signal Induction;Signal Pathway;single cell analysis;single cell ATAC-seq;Solid;Spleen;T-Lymphocyte;Testing;THC exposure;Tissue Sample;Tissues;tool;transcriptome sequencing;Viral;viral DNA;Viral Physiology;Viral reservoir;viral RNA;Viremia;Virus Latency;Work

PROJECT_TITLE: Defining the impact of cannabinoids on the HIV reservoir in humanized mice


NIH_SPENDING_CATS: Breastfeeding, Lactation and Breast Milk;Clinical Research;Health Services;Patient Safety;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

PHR: Project Narrative Human Teratogens Course Pregnant or breastfeeding individuals are often worried about exposures such as medications, maternal diseases, chemicals in the environment, infectious agents, and other substances and seek counseling from their healthcare providers. The Human Teratogens Course educates healthcare providers with up-to-date information on exposures during pregnancy and breastfeeding. The course also teaches healthcare providers how to assess and evaluate the benefits and risks of these exposures to better counsel their patients and improve the quality of their services.

PI_NAMEs: OBICAN, SARAH GLORIA (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Ally;Area;Benefits and Risks;Breast Feeding;career;Caring;Chemicals;clinical practice;Communication;Confusion;Congenital Abnormality;Continuing Education;Counseling;Country;Developing Countries;Discipline of Nursing;Disease;diversity and inclusion;Education;Educational process of instructing;Embryology;Environment;Epidemiology;Event;evidence base;Exposure to;Faculty;Fees;Fetus;Florida;Foundations;Genetic Counseling;genetic counselor;Goals;Gynecologist;Health;Health Personnel;Health Professional;Healthcare;Human;improved;improved outcome;Individual;Infant;Infection;Infectious Agent;Information Specialists;interest;International;Knowledge;Lactation;Learning;lectures;Location;Medicine;meetings;member;Midwife;Outcome;Parents;Participant;Patient-Focused Outcomes;Patients;pediatrician;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Pregnancy;pregnant;Prevention;Professional Organizations;Provider;Quality of Care;Research;Research Personnel;Resources;Risk;Risk Assessment;Scientist;Services;skills;Societies;symposium;Teratogens;Teratology;tool;Toxicology;Training and Education;Translational Research;Translations;Universities;virtual;waiver

PROJECT_TITLE: Human Teratogens Course

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


ADMINISTERING_IC: NS

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: WEST LAFAYETTE

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Aging is a key risk factor for many chronic diseases, including Alzheimer’s disease. This proposal aims at examining the role of R-loops in mechanisms of transcriptional stress, genome instability, and chronic immune response; all hallmarks of aging. Successful completion of proposed aims should provide new avenues for therapeutic approaches targeting these hallmarks, and thus slowing down onset or progression of neurodegenerative disease.

PI_NAMEs: HALL, HANA  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Acceleration;Address;Age;age related;age related neurodegeneration;Age related pathologies;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;Autopsy;Basic Science;biological adaptation to stress;Blindness;Brain;Chronic;Chronic Disease;Clinical;Cytoplasm;Data;Defect;Dementia;Development;DNA;DNA Damage;Drosophila genus;Drosophila melanogaster;Elderly;Epigenetic Process;epitranscriptomics;Eukaryota;Exogenous Factors;Functional disorder;Gene Expression;Genetic Transcription;Genome;Genomic Instability;genomic locus;hallmarks of aging;Health;Hippocampus;Homeostasis;Human;Hybrids;Immune response;Impairment;In Vitro;Incidence;Individual;Inflammation;Inflammatory Response;Late Onset Alzheimer Disease;Lead;Link;Methyltransferase;model organism;Modification;Molecular;mouse model;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuroinflammation;Neurologic;Neurons;novel;novel therapeutic intervention;nucleic acid structure;Pathway interactions;Patients;posttranscriptional;Process;Rattus;Reporting;Research;Research Proposals;Resistance;Resolution;Risk Factors;RNA;RNA metabolism;RNA methylation;Role;Single-Stranded DNA;Stress;Symptoms;System;tau aggregation;tau Proteins;Therapeutic;Toxic effect;Vision

PROJECT_TITLE: Role of R-loops in transcriptional stress, genome instability, and chronic immune response in Alzheimer's disease

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE: UBTF tandem duplications (UBTF-TD) in exon 13 were recently described by our group as a new recurrent and likely class-defining somatic alteration in pediatric AML that is associated with poor outcome. In this proposal, we will use newly developed human and mouse models and a large series of primary patient samples to dissect the molecular impact of UBTF-TD expression through a combination of functional and multi-omic approaches. The successful completion of these studies will provide the first mechanistic insights into how this recently identified mutation in a gene that encodes for a nucleolar protein disrupts hematopoietic development to drive leukemia formation and will ultimately aid in the identification of therapeutic options for this new high-risk subtype of pediatric AML.

PI_NAMEs: KLCO, JEFFERY M (contact)

PROGRAM_OFFICER_NAME: SAYYED, ZULEKHA I

PROJECT_TERMS: Acute Myelocytic Leukemia;Adult;ATAC-seq;Binding;Biogenesis;Biological Models;C57BL/6 Mouse;Categories;CD34 gene;Cell model;Cells;chemotherapy;Child;Childhood Acute Myeloid Leukemia;Childhood Leukemia;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Collaborations;conventional therapy;CRISPR/Cas technology;Cytogenetics;Data;Development;Diagnosis;Engraftment;Epigenetic Process;Event;Exons;FLT3 gene;Fusion Oncogene Proteins;Future;Gene Expression Profile;Gene Expression Profiling;Gene Frequency;Genes;Genetic;Genetic Transcription;genetic variant;Genome;Genomics;Germ Lines;Goals;Growth;Hematopoiesis;Hematopoietic;Heterozygote;high risk;Human;human model;Immunodeficient Mouse;improved;in silico;in vivo Model;Inferior;insight;Karyotype;knowledge of results;Lead;Lesion;leukemia;leukemic transformation;leukemogenesis;loss of function mutation;Maintenance;Mediating;MLL gene;Modeling;Molecular;molecular subtypes;mouse model;multiple omics;Mus;Mutation;novel;Nucleolar Proteins;Outcome;patient derived xenograft model;Patients;Penetrance;Phenotype;programs;Proliferating;Proteins;Recurrence;Recurrent disease;Relapse;Reporting;Residual Neoplasm;Resistance;Ribosomes;Role;Sampling;self-renewal;Series;small molecule inhibitor;Testing;Therapeutic;therapeutic target;tool;transcription factor;Transplantation;Trisomy 8;Umbilical Cord Blood;WT1 gene

PROJECT_TITLE: UBTF Tandem Duplications in Pediatric Acute Myeloid Leukemia

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative Altered expression or function of KDM5 family genes can result in two clinical pathologies: cancer and intellectual disability. To understanding how dysregulation of KDM5 causes these disorders, we first require detailed knowledge of how these transcriptional regulators carry out their normal physiological functions in vivo, which is the goal of this research proposal.

PI_NAMEs: SECOMBE, JULIE  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Affect;Alleles;Amino Acids;Animals;Autophagocytosis;Binding;Biological;Biology;Cell Physiology;Cells;Chromatin;Clinical Pathology;Complex;Data;Deletion Mutation;Development;Disease;Drosophila genus;Elements;Essential Genes;Family;Gene Expression;Gene Expression Regulation;Gene Family;Genes;Genetic;Genetic Transcription;Genomics;Goals;histone demethylase;Human;in vivo;innovation;insight;Intellectual functioning disability;Investigation;Knowledge;Label;Link;Lysine;male;Malignant Neoplasms;Mediating;Missense Mutation;model organism;Molecular;mutant;Nonsense Mutation;Pathway interactions;Physiological;Production;programs;promoter;Protein Family;protein protein interaction;Proteins;recruit;Regulation;Regulator Genes;Reporter;Research Proposals;RNA Polymerase II;Role;Series;Techniques;Terminator Codon;Tertiary Protein Structure;Testing;Time;Transcriptional Activation;Transcriptional Regulation;transcriptomics;Work

PROJECT_TITLE: Non-canonical mechanisms of gene regulation by the histone demethylase KDM5

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]