NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Natural Products;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative: Alopecia is a major side effect of Taxol (paclitaxel), a key drug in the current treatment of ovarian and other cancers, used as a frontline agent in combination with carboplatin/cisplatin, and a second line drug with a dose intensive regimen following recurrence. We have made an important finding that low intensity ultrasound can effectively neutralize the cytotoxic effect of paclitaxel on cultured cells by disrupting paclitaxel-induced rigid and stabilized microtubule bundles, removing the cell killing activity of paclitaxel. The proposed study aims to develop and apply this discovery to protect the highly proliferative hair follicle cells from paclitaxel cytotoxicity, which will prevent short-term and permanent alopecia and improve the quality of life for cancer patients undergoing treatment.

PI_NAMEs: XU, XIANGXI MIKE  (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: Acute;Adverse effects;Age;Alopecia;Autophagocytosis;Basic Science;Binding;Biological;Biology;Breast;Cancer Patient;cancer recurrence;Cancer Survivor;cancer therapy;Carboplatin;Cell Cycle Inhibition;Cell Death;cell injury;cell killing;Cell Proliferation;cell type;Cell-Free System;Cells;Cellular biology;Cessation of life;chemotherapy;Chemotherapy-Oncologic Procedure;Cisplatin;Clinical Oncology;clinical practice;clinical trial protocol;Complex;Cultured Cells;Cytoskeleton;cytotoxic;cytotoxicity;Dermatologist;design;docetaxel;dosage;Dose;Dose Limiting;Drug Exposure;Drug usage;epithelial stem cell;Epithelium;Exhibits;Experimental Designs;experimental study;Exposure to;Frequencies;Funding;Future;Gender;Goals;Growth;Hair;Hair Cells;Hair follicle structure;Histology;Human;Immune;Immunofluorescence Microscopy;Implant;improved;In Vitro;in vivo;interdisciplinary collaboration;keratinocyte;Lysosomes;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;Metabolism;Metastatic breast cancer;Microscopy;Microtubule Bundle;Microtubule Polymerization;Microtubule Stabilization;Microtubules;Mitotic;Modeling;mouse model;Mus;Natural Killer Cells;Neutropenia;Non-Small-Cell Lung Carcinoma;Oncologist;Organ Culture Techniques;Ovarian;Paclitaxel;Pathology;Patients;Pharmaceutical Preparations;Phenotype;prevent;Prevention;Procedures;Proliferating;Prostate;Quality of life;Race;Recurrence;Regimen;response;Safety;Scalp structure;Schedule;sensory neuropathy;Shock;side effect;single-cell RNA sequencing;Skin;Solid Neoplasm;stem cells;Surface;System;taxane;Technology;Testing;Time;Toxic effect;Translating;transplant model;Transplantation;Ultrasonic Therapy;Ultrasonic wave;Ultrasonography;ultrasound;Work

PROJECT_TITLE: Countering microtubule stabilization within hair follicles in ovarian cancer chemotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-L (02)]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Lung;Pediatric;Precision Medicine;Rare Diseases

ORG_CITY: ATLANTA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The majority of cases of pediatric acute respiratory distress syndrome (PARDS) are triggered by lower respiratory tract infections, and more that 40% of children who die PARDS-related deaths were previously healthy, very young children. The unique airway environment of each child contributes to the heterogeneity of PARDS, and there is a lack of insight into how the airway environment influences immunity, resulting in a lack of therapies that hasten recovery from PARDS. The goal of this research is to determine whether neutrophil death promotes sustained inflammation leading to poor clinical outcomes in intubated children with PARDS, to explain the heterogeneity of PARDS, to enable risk stratification, and to inform the development of targeted therapies to reduce the high occurrence of PARDS-related disability and death.

PI_NAMEs: GRUNWELL, JOCELYN REBECCA (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Affect;Air;airway immune response;Alveolar;Anti-viral Response;Apoptosis;Bacteria;Biological Assay;Biological Models;Blood;Cell Culture Techniques;Cell Death;cell free DNA;cell type;Cessation of life;Child;Child health care;Clinical;co-infection;Complex;Critically ill children;cytokine;Cytokine Signaling;Cytoplasmic Granules;Data;Development;disability;DNA;Endothelial Cells;Environment;Epithelial Cells;Event;Exocytosis;experience;extracellular;follow-up;Functional disorder;Gene Expression;gene network;Goals;Heterogeneity;Histones;Hypoxemia;Immobilization;Immune;Immune response;Immunity;improved;Individual Differences;Inflammation;Inflammatory;inflammatory milieu;Infrastructure;insight;Internet;Intubation;Invaded;Investigation;K-Series Research Career Programs;Link;longitudinal analysis;Lower Respiratory Tract Infection;Lung Diseases;lung injury;machine learning method;Mediating;Mentored Patient-Oriented Research Career Development Award;Metabolic Pathway;metabolomics;migration;Molecular;Morbidity - disease rate;mortality;multiple omics;National Heart, Lung, and Blood Institute;neutrophil;non cardiogenic pulmonary edema;Nucleosomes;Outcome;pathogen;Pathology;Patients;Pattern;Pediatric Acute Respiratory Distress Syndrome;Peptide Hydrolases;personalized medicine;Phenotype;precision medicine;Reactive Oxygen Species;Recovery;Regulatory T-Lymphocyte;Research;response;Risk;risk stratification;Sampling;Severities;Strategic Planning;Survivors;Syndrome;T cell response;T-Lymphocyte;targeted treatment;Testing;Training;transcriptome sequencing;transcriptomics;treatment response;Universities;Ventilator;Viral

PROJECT_TITLE: Longitudinal Analysis of Blood and Airway Immune Response: Precision Medicine for

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


ADMINISTERING_IC: CA

ED_INST_TYPE: HOSPITALS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Neurofibromatosis;Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative Neurofibromatosis type 1 (NF1) is an inherited genetic condition in which benign tumors develop along the nerve tissues. Challenges for the clinical management of this disease include the surveillance patients must undergo, a relative paucity of treatment options for late-stage disease, and the monitoring for recurrence following surgical treatment. We propose to apply state of the art genomic technologies and novel computational algorithms to profile blood combined with radiology to support noninvasive risk assessment, early detection, and post- treatment monitoring of this population and to improve patient outcomes.

PI_NAMEs: SCHEET, PAUL A;TORRES, KEILA ENITT (contact)

PROGRAM_OFFICER_NAME: MAZURCHUK, RICHARD V

PROJECT_TERMS: accurate diagnosis;active method;Address;Affect;Aftercare;American;Aneuploidy;Benign;Binding;Biological Assay;Biological Markers;Biopsy;Blood;cell free DNA;Classification;Clinical;clinical biomarkers;Clinical Management;clinically relevant;cohort;Complement;Computational algorithm;Cutaneous;Data;Dermal;Detection;Development;Diagnosis;Diagnostic;diagnostic panel;diagnostic tool;Diffuse;Disease;Disease Management;DNA;DNA Markers;DNA Methylation;Early Diagnosis;Early Intervention;Genes;Genetic Diseases;genome sequencing;Genomics;Glucose;Goals;Haplotypes;Heterogeneity;high risk;Hypermethylation;Image;imaging biomarker;imaging modality;improved;Individual;Information Systems;Inherited;innovation;Institution;Intervention;Intramuscular;Lesion;Link;loss of function;Machine Learning;Magnetic Resonance Imaging;Malignant - descriptor;Malignant Neoplasms;Maps;Measures;Methylation;methylation biomarker;methylome;Modality;Monitor;Monitoring for Recurrence;Morbidity - disease rate;mortality;multidisciplinary;multiparametric imaging;Mutation;neoplastic cell;Nerve Plexus;Nerve Tissue;neural;neurofibroma;Neurofibromatosis 1;Neurofibrosarcoma;novel;Operative Surgical Procedures;Outcome;Pain;Patient-Focused Outcomes;Patients;Physicians;Plasma;Plexiform Neurofibroma;Population;Positron-Emission Tomography;post intervention;Proliferating;prospective;Quality of life;Radiology Specialty;Recurrence;Recurrent disease;Reporting;Risk Assessment;Role;Sampling;Sarcoma;Source;Spinal;Survival Rate;Techniques;Technology;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;treatment response;tumor;tumor DNA;tumor heterogeneity;Tumor Tissue;Validation;Variant;whole genome;X-Ray Computed Tomography

PROJECT_TITLE: Use of Noninvasive Biomarkers and Advanced MRI for early detection of NF1-associated MPNSTs

STUDY_SECTION: MCDC

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Narrative Albeit intensive mitigation strategies are applied to manage known clinical risk factors, atherosclerotic cardiovascular disease (ASCVD) risks remain high in the type 2 diabetic (T2DM) population. Results using our novel computational programs suggested a T2DM-ASCVD unique super-network could directly contribute to ASCVD mechanistically and predictively. This project will functionally test the impact of these regulators and assess their contribution to improving T2DM-ASCVD predictive modeling.

PI_NAMEs: VELLA, ANTHONY T;ZHOU, BEIYAN  (contact)

PROGRAM_OFFICER_NAME: KIRBY, RUTH

PROJECT_TERMS: Accounting;Adoptive Transfer;Affect;Algorithms;annotation  system;Atherosclerosis;atherosclerosis risk;cardiovascular disorder risk;causal variant;Cell Physiology;cell type;Cells;Clinical;clinical risk;Clinical Trials;cohort;Cohort Studies;Complex;Data;Data Analyses;Data Set;Development;drug development;efficacy evaluation;Equation;evidence base;Exhibits;feature extraction;feature selection;Foam Cells;Future;Genes;genetic signature;Health Care Costs;Healthcare Systems;high risk;Human;Hypertension;Immune;Immunology;improved;In Vitro;Incidence;Inflammatory;innovation;Investigation;knock-down;Knowledge;Ligation;Lipids;Machine Learning;Macrophage;Methods;Modeling;Molecular;molecular drug target;monocyte;Multi-Ethnic Study of Atherosclerosis;multiple omics;Mus;NCOR2 gene;Non-Insulin-Dependent Diabetes Mellitus;novel;overexpression;Pathogenicity;Patients;Performance;Peripheral Blood Mononuclear Cell;personalized intervention;Persons;Population;predictive modeling;predictive tools;Process;Program Development;programs;Proteins;Resolution;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;RNA Splicing;Role;SNW1 Gene;System;Systems Development;T-Lymphocyte;Testing;Tissues;tool;transcriptomics;Type 2 diabetic;Underachievement;Volatilization;Work

PROJECT_TITLE: ASCVD risk assessment in T2DM facilitated by novel computational immunology programs

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Nutrition

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE: Chronic Kidney Disease (CKD) affects 15% of the adult population in the United States and these patients have a fracture rate 2 to 15 times that of the general population, yet our current approach to focus only on parathyroid hormone has not been effective in reducing fractures. In the current proposal, we will test if a toxin that accumulates in CKD is a cause of the extra fracture risk seen in patients with CKD.

PI_NAMEs: ALLEN, MATTHEW R;MOE, SHARON M (contact);WALLACE, JOSEPH MICHAEL

PROGRAM_OFFICER_NAME: CHAN, KEVIN E

PROJECT_TERMS: Adenine;Adult;Affect;Age;Aging;Apoptosis;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;aryl hydrocarbons;biomechanical test;Biopsy;bone;Bone Diseases;bone fragility;bone quality;Bone remodeling;bone turnover;Calcium;Cell Line;Cells;Chronic Kidney Failure;Clinical;Complex;Data;Defect;design;Diet;dietary;Dietary Fiber;Dietary Intervention;Drug Metabolic Detoxication;Excretory function;Fiber;Fracture;fracture risk;Functional disorder;Gene Expression;General Population;Genes;Genetic Transcription;gut microbiome;gut microbiota;Hip Fractures;Human;Impairment;improved;In Vitro;in vivo;Indican;Individual;inhibitor;Inulin;Kidney;Knockout Mice;Measures;mechanical properties;Mediating;microCT;mineralization;Minerals;Modeling;mouse model;Mus;nanoindentation;novel;novel strategies;Oral Administration;osteoblast differentiation;Osteoblasts;Osteoclasts;Osteocytes;Outcome;Outcome Assessment;Pathogenesis;Patients;pharmacologic;Phenotype;Population;Porosity;prevent;pro-aging;Production;promoter;PTH gene;Raman Spectrum Analysis;Rattus;receptor;Receptor Signaling;Renal clearance function;Renal Osteodystrophy;Risk;Role;Secondary Hyperparathyroidism;Serum;Signal Pathway;Signal Transduction;steroid hormone metabolism;Structure;Testing;Therapeutic;Time;Tissues;Toxin;Treatment Efficacy;United States;Uremia;Work

PROJECT_TITLE: Uremic toxins and osteocyte dysfunction in CKD

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Diabetes;Nutrition;Obesity

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Obesity is an endocrine disorder that remains the most universal contributor to type 2 diabetes. In this proposal, we want to understand how local hormone actions influence the function of fat cells. At the end of our studies, we expect to uncover new ways to treat obesity and type 2 diabetes.

PI_NAMEs: HARTIG, SEAN  (contact)

PROGRAM_OFFICER_NAME: GUPTA, DHANANJAY

PROJECT_TERMS: Adipocytes;Adipose tissue;Adrenergic Receptor;Affect;Alleles;Animals;Anti-diabetic Drugs;Auranofin;Behavior Therapy;beta-adrenergic receptor;Biological Availability;Blood;Body fat;Body Weight;Brain;Carbohydrates;Cardiovascular Diseases;Central Nervous System;Chronic;Clinical Research;clinically relevant;Closure by clamp;comorbidity;Competence;conditional knockout;Data;desensitization;Dose;Doxycycline;Eating;Educational process of instructing;Elements;Endocrine;Endocrine Glands;Endocrine System Diseases;energy balance;Epidemic;expectation;experimental study;Fatty Liver;fatty liver disease;FDA approved;Gene Expression;Genetic;Glucose;glucose disposal;Goals;Health;Homeostasis;Hormones;Hunger;Hyperphagia;improved;Inflammatory;Insulin Resistance;insulin sensitivity;Knock-out;Knowledge;LEPR gene;Leptin;Leptin deficiency;leptin receptor;Leptin resistance;Life Style Modification;Lipids;Lipolysis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;Molecular;Molecular Target;mouse model;Mus;Neurons;Non-Insulin-Dependent Diabetes Mellitus;Nonesterified Fatty Acids;Nutrient;Obese Mice;obese person;Obesity;Obesity Epidemic;obesity treatment;Pathway interactions;Peripheral;Persons;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Population;Pre-Clinical Model;Prevention strategy;Production;Property;Proteins;Quality of life;Receptor Activation;Recombinants;Regulation;Repression;Research;Research Proposals;response;Rheumatoid Arthritis;Role;Serum;Signal Transduction;Site;Testing;Therapeutic;Triglycerides;Wild Type Mouse

PROJECT_TITLE: Molecular regulation of leptin bioavailability

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-S (02)]


ADMINISTERING_IC: GM

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: PROJECT NARRATIVE During the onset of vertebrate organogenesis, the emergence of repetitive morphological units is tightly coupled to the expression of morphogens. Using assays designed to infer supracellular material properties, here we study how morphogens enable interacting supracellular phases primed with the capacity to generate organ architecture. This investigation develops a generalizable paradigm for how morphogen modulation of supracellular dynamics shapes organs, which may serve as a foundation for future work aimed at tissue engineering and repair.

PI_NAMEs: SHYER, AMY ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Address;Architecture;Attention;Behavioral Assay;Biological Assay;Biophysics;Birds;cell behavior;Cell Physiology;Cells;Congenital Abnormality;Coupled;Cues;design;Development;Disease;Dose;Engineering;Epithelium;Event;experimental study;Extracellular Matrix;Feathers;Feedback;Fibroblast Growth Factor;Fibroblasts;Foundations;Future;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;Genetic Transcription;Individual;interest;Investigation;Length;Link;Liquid substance;mechanical behavior;Mechanics;Mediating;Mediator;Mesenchymal;Mesenchyme;Modality;Modeling;Molecular;Morphogenesis;morphogens;Morphology;Movement;Natural regeneration;Nature;Neoplasm Metastasis;novel;Organ;Organogenesis;Outcome;Pattern;Pattern Formation;Phase;phase change;physical model;physical property;Property;Regenerative Medicine;Role;self organization;Shapes;Signal Transduction;Skin;Solid;Stromal Neoplasm;Structure;Testing;theories;Time;Tissue Engineering;tissue repair;Tissues;tumor;Work

PROJECT_TITLE: Establishing the effect of morphogens at the supracellular scale during organ formation

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Structural Anomalies;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Substance Misuse

ORG_CITY: PHILADELPHIA

ORG_NAME: TEMPLE UNIV OF THE COMMONWEALTH

ORG_STATE: PA

PHR: Narrative The brain cells of a fetus give off small vesicles called “exosomes”, which find their way into the mother's blood and can be purified from the blood without disturbing the fetus. We will determine whether molecules in these fetal-derived exosomes can predict which at-risk fetuses will be born with fetal alcohol syndrome (FAS), the most involvedend of the fetal alcohol spectrum disorders( FASD), or one of the partial forms, the most common cause of developmental intellectual disability in the US. Non-invasive in utero diagnosis could lead to earlier detection and better research into therapies to prevent or ameliorate FAS/D.

PI_NAMEs: SELZER, MICHAEL EDGAR (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: Address;Affect;Age;Alcohol consumption;alcohol consumption during pregnancy;Alcohols;Antibodies;Apoptosis;Apoptotic;Attentional deficit;Back;Biological Assay;Biological Markers;biomarker identification;Birth;Blood;Blood specimen;Body Weight;Brain;brain cell;brain size;Cell Lineage;cell type;Characteristics;chemokine;Child;Childhood;Clinical;Clinical Research;Collaborations;Consumption;contactin;cytokine;Data;Defect;Development;Diagnostic;Diameter;digital;Disease;Dryness;dysmyelination;Early Diagnosis;Enzyme-Linked Immunosorbent Assay;Exclusion;exosome;Eye;Face;feature detection;fetal;Fetal Alcohol Exposure;Fetal Alcohol Spectrum Disorder;Fetal Alcohol Syndrome;fetal diagnosis;Fetus;fetus at risk;First Pregnancy Trimester;follow-up;Follow-Up Studies;Freezing;Gestational Age;Glucuronides;Guidelines;Head circumference;Health;Human;human fetal brain;human tissue;Hyperactivity;imaging modality;Imaging Techniques;Immunoprecipitation;in utero;in utero diagnosis;Infant;Inflammatory;Injury;Insulin-Like Growth Factor I;Intake;Intellectual functioning disability;Learning;Length;Light;Lip structure;maternal alcohol use;maternal obesity;Measures;Messenger RNA;Microcephaly;Microglia;Molecular;Molecular Abnormality;molecular marker;Morphology;Mothers;mRNA Expression;Multiple Sclerosis;Myelin;Myelin Basic Proteins;myelination;neonate;Neonatology;neurobehavioral;neurodevelopment;Neurodevelopmental Disorder;neurofilament;neuron apoptosis;neuron loss;Neurons;neuroprotection;neurotoxicity;Newborn Infant;oligodendrocyte progenitor;Oligodendroglia;Patient Self-Report;Patients;Plasma;Platelet-Derived Growth Factor alpha Receptor;postnatal;precursor cell;predictive marker;Pregnancy;pregnant;Pregnant Women;prenatal;Prenatal care;prevent;Proteins;PTPRC gene;Questionnaires;Race;Rattus;Recording of previous events;Recreational Drugs;recruit;Research;Research Personnel;Resolution;Risk;RNA;screening;Self Assessment;Serum;Severities;sex;Signal Transduction;Socioeconomic Status;Source;Speech;Spottings;stem cell biomarkers;Substance of Abuse;Surface;Surveys;Synapses;Synaptic plasticity;Synaptophysin;Syndrome;Testing;therapeutic development;Therapeutic Intervention;therapy development;Third Pregnancy Trimester;Time;timeline;TNF gene;Tobacco use;ultrasound;University Hospitals;Urine;Vesicle;Visit;Woman;Work

PROJECT_TITLE: Fetal-Derived Exosome Cargos in Maternal Blood to Predict Fetal Alcohol Syndrome

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The proposed ancillary study will leverage an ongoing randomized controlled trial to address whether statins prevent two of the most common cardiovascular conditions experienced by older adults—heart failure with preserved ejection fraction (HFpEF) and acute myocardial infarction (AMI). This proposal will also determine the negative impact of relying on diagnosis codes to identify HFpEF and AMI events in the modern era. The proposed research is consistent with the broader public health goals of disease prevention, and addresses NHLBI Strategic Vision Objective 5 to “develop and optimize novel… therapeutic strategies to prevent… diseases.”

PI_NAMEs: GOYAL, PARAG  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Acute myocardial infarction;Address;adjudication;Adult;Affect;aged;Aging;Ancillary Study;Benefits and Risks;Biological;Biological Markers;Biometry;Cardiology;cardiovascular disorder epidemiology;Cardiovascular system;Classification;Clinical;clinical practice;Clinical Trials;Code;Computerized Medical Record;cost;Data;Dementia;Detection;detection sensitivity;Diagnosis;Diagnostic;Disease;disorder prevention;Double-Blind Method;EFRAC;Elderly;endothelial dysfunction;Evaluation;Event;evidence base;experience;follow-up;Funding;Goals;Guidelines;health goals;Heart Abnormalities;Heart failure;Hospitalization;improved;Inflammation;Infrastructure;insight;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Ischemia;Knowledge;Lipids;Medical;Medical Records;men;Modernization;Morbidity - disease rate;mortality;Myocardial;Myocardial Infarction;National Heart, Lung, and Blood Institute;Natriuretic Peptides;novel therapeutic intervention;Observational Study;older adult;Outcome;Parents;Participant;Performance;Population;preservation;prevent;Prevention strategy;primary outcome;Public Health;Qualifying;randomized placebo controlled trial;Randomized, Controlled Trials;Reasons for Geographic And Racial Differences in Stroke;Records;Reporting;Research;Research Design;Retrieval;Risk;Risk Reduction;secondary outcome;Site;Strategic vision;Testing;treatment pattern;Troponin;United States National Institutes of Health;Woman

PROJECT_TITLE: Preventing Myocardial Events of Aging: A PREVENTABLE Ancillary Study

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Obesity;Physical Activity;Prevention;Rehabilitation;Social Determinants of Health;Telehealth

ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative The goal of this research is to evaluate the effect of digitally delivered social support training for promoting sustained moderate-to-vigorous physical activity increases, using a cluster randomized controlled trial. Self- selected teams of 3-8 insufficiently active adults (about 60 teams comprised of a total of N=300 participants) will be randomized to receive either a 3-month, theory-based, remotely delivered physical activity intervention (mobile-compatible web app with behavior change content, Fitbit physical activity tracker, tailored goals, and feedback) or the same intervention plus digitally delivered social support training. The proposed research will yield essential, rigorous evidence on a novel and promising strategy for leveraging existing social relationships to enhance physical activity among insufficiently active adults, using a scalable platform that can readily be disseminated.

PI_NAMEs: MONROE, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Accelerometer;Accountability;active lifestyle;Adult;Advisory Committees;Behavior;behavior change;Behavioral Weight Control;Body Weight decreased;cardiovascular health;Communication;Communication Tools;Communities;Couples;crowdsourcing;design;digital;digital delivery;digital intervention;digital platform;Dose;Empathy;Epidemiology;epidemiology study;exercise intervention;experimental study;Feedback;fitbit;follow-up;Fostering;Goals;Guidelines;Health Benefit;Healthcare;improved;Individual;Intervention;Interview;Knowledge acquisition;life span;Link;Long-Term Effects;Maintenance;Measures;Mediating;Mediator;Metabolic;Methods;Minority;mobile application;Modeling;moderate-to-vigorous physical activity;Motivation;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;Participant;peer;Persons;Physical activity;physical conditioning;Population;post intervention;Preventive service;Process;programs;psychosocial;psychosocial outcome;Public Health;public health priorities;Randomized;Randomized, Controlled Trials;Recommendation;recruit;remote delivery;Research;response;Risk;Sampling;Series;skill acquisition;skills;social;social engagement;Social Environment;social relationships;Social support;Social Values;staff intervention;Technology;Testing;theories;Time;Training;Training Activity;Training Support;trial comparing;web app

PROJECT_TITLE: Using Existing Social Ties to Promote Physical Activity: Effects of Digitally Delivered Team Social Support Training

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Lung;Physical Activity;Prevention;Substance Misuse;Tobacco

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE For healthy young adults who use electronic cigarettes (e-cigarettes), we still do not clearly understand their health effects. This significant knowledge gap hampers effective medical management and policy decision. In this proposal, we will deploy a sensitive imaging signature, hyperpolarized xenon-129 MRI, to determine the pathologic lung effects induced by e-cigarette use.

PI_NAMEs: MUGLER, JOHN P;SHIM, YUN MICHAEL (contact)

PROGRAM_OFFICER_NAME: DRGONOVA, JANA

PROJECT_TERMS: 3-Dimensional;Acute;Acute Lung Injury;Address;Adopted;Age;Blood capillaries;Cardiopulmonary;Chronic Obstructive Pulmonary Disease;Clinical;clinical diagnostics;clinical trial protocol;Clinical Trials;clinically relevant;combustible cigarette;commercialization;Data;detector;Diagnostic;diagnostic tool;Dose;Electronic cigarette;electronic cigarette use;electronic cigarette user;endothelial dysfunction;Epithelium;Evaluation;Exercise;exercise capacity;Exercise Test;follow-up;Functional disorder;Gases;Health;Heart Diseases;Human;Image;imaging biomarker;Impairment;interstitial;Interstitial Lung Diseases;Juice;Knowledge;Link;Lung;Lung Diseases;lung health;Magnetic Resonance Imaging;Maps;Medical;Microscopic;novel diagnostics;novel marker;Oxygen;Pathologic;Pathology;Patients;Performance;Phase;Physiological;Physiology;Pilot Projects;Policies;Pre-Clinical Model;Protocols documentation;pulmonary function;Pulmonary function tests;Pulmonary Gas Exchange;Pulmonary Pathology;pulmonary vascular disorder;Research Design;Resolution;Respiratory Failure;SARS-CoV-2 infection;Stress Tests;Techniques;Time;Tissues;Universities;Update;uptake;vaping;Vascular Diseases;Virginia;Visit;VO2max;X-Ray Computed Tomography;Xenon;young adult

PROJECT_TITLE: Dissolved Phase Hyperpolarized Xenon-129 MRI: a novel biomarker to quantify pulmonary pathology in young healthy e-cigarette users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-C (03)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics;Nutrition;Obesity;Physical Injury - Accidents and Adverse Effects;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE An aberrant Unfolded Protein Response (UPR), due to continued protein folding and processing overload in the endoplasmic reticulum (ER), is known to drive obesity-related co-morbidities. We found compelling evidence that UPR is dysregulated during osteogenic repair in obesity and may underlie poor fracture outcomes in obese individuals, that prolong disability and often necessitate surgical intervention. Using genetic and pharmacologic tools, this proposal will determine if targeting one or more response arms of the UPR in skeletal stem cells can alleviate the obesity-related fracture repair deficits.

PI_NAMEs: IYER, SRIVIDHYA  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Adipocytes;Apoptosis;arm;ATF6 gene;B-Lymphocytes;bone;Bone callus;bone fracture repair;bone healing;bone repair;Cells;Chemicals;Chronic;comorbidity;Complications of Diabetes Mellitus;Cryoultramicrotomy;Cues;Data;Defect;disability;EIF-2alpha;Endoplasmic Reticulum;endoplasmic reticulum stress;Endothelium;Exhibits;feeding;Fluorescence;Fracture;fracture risk;Gene Modified;gene repression;Genes;Genetic;genetic signature;Genetic Transcription;Growth;High Fat Diet;Histology;human model;Impairment;improved;In Vitro;in vivo;Incidence;Individual;Inflammatory;Injury;Link;lipid biosynthesis;Marrow;Measures;Mediating;Mediator;Medical Care Costs;Metabolic;Metabolic dysfunction;Modeling;Molecular Chaperones;Mus;neutrophil;novel;novel therapeutic intervention;Obese Mice;obese person;Obesity;Ontology;Operative Surgical Procedures;Osteoblasts;Osteogenesis;osteogenic;osteoprogenitor cell;Osteotomy;Outcome;Output;overexpression;pharmacologic;Phase;Phenotype;Physiologic Ossification;Physiological;preclinical study;Predisposition;Process;progenitor;Proliferating;Protein Biosynthesis;protein folding;Proteins;remediation;repaired;Reporter;response;Reticular Cell;ribosome profiling;Rodent Model;Role;sensor;Signal Transduction;single-cell RNA sequencing;skeletal;skeletal stem cell;small molecule;Stromal Cell-Derived Factor 1;tauroursodeoxycholic acid;Testing;Therapeutic;Tibial Fractures;tool;Torsion;transcriptome;Translational Repression;Translations;Up-Regulation;WNT Signaling Pathway;XBP1 gene

PROJECT_TITLE: Targeting Unfolded Protein Response (UPR) to improve fracture repair in obesity


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cardiovascular;Gene Therapy;Genetics;Heart Disease

PHR: PROJECT NARRATIVE Gene therapy for inherited and acquired cardiovascular diseases has been limited by either low efficiency or toxicity of the vectors used to introduce genes into cells of the heart. We will investigate how gene therapy using a promising vector approach that relies on bioengineered adeno-associated viruses (AAVs) can be improved by site-directed ultrasound-mediated cavitation of microbubble contrast agents. These studies are intended to produce vital knowledge of ideal conditions, efficacy, and safety of cavitation-mediated transduction needed for translation into humans.

PI_NAMEs: FRENCH, BRENT A;LINDNER, JONATHAN R (contact)

PROGRAM_OFFICER_NAME: LUO, JAMES

PROJECT_TERMS: Acoustics;adeno-associated viral vector;Adenovirus Vector;Adenoviruses;Adoption;Adverse effects;Adverse event;Affect;attenuation;Binding;Binding Proteins;Biological Assay;Biomedical Engineering;Blood;Blood Vessels;C3 gene;Capsid;Cardiac;Cardiac Myocytes;Cardiomyopathies;Cardiovascular Diseases;Caring;Caveolins;Cell Nucleus;Cells;Charge;Chromosomes;clinical practice;Clinical Trials;clinically relevant;Contrast Media;cost;Coupled;Coupling;density;Dependovirus;design;Development;Diagnostic;Disease;DNA;DNA delivery;Dose;early phase clinical trial;Echocardiography;efficacy evaluation;efficacy testing;Endothelial Cells;Endothelium;Engineering;Episome;Evaluation;Event;experimental study;Family;Frequencies;Functional disorder;Gene Delivery;Gene Expression;gene therapy;Gene Transfer;Genes;Genetic Materials;Geometry;Glycocalyx;Goals;Heart;heart cell;Heart Hypertrophy;Histology;Human;human disease;human model;Hypertrophic Cardiomyopathy;Immune;immunoreaction;improved;Inflammation;Inherited;Injections;insight;Intercellular Junctions;interest;intravenous injection;Ischemia;Japanese Monkey;Knowledge;Laboratories;Left;Lentivirus;Lipids;Measures;Mediating;member;Methods;Microbubbles;Modeling;Modification;mouse model;multiorgan damage;Mus;Muscle Cells;Mutation;myocardial injury;Myosin ATPase;Neuraminidase;Nitric Oxide;Non-Viral Vector;nonhuman primate;Nuclear;Optical reporter;Organ;Parvovirus;Patients;Pericytes;Permeability;Phenotype;Physiologic pulse;plasmid DNA;Plasmids;Positron-Emission Tomography;Pre-Clinical Model;preclinical study;Preparation;pressure;Primates;Production;Prostaglandins;Proteins;Protocols documentation;receptor;Recombinants;Reporter;response;Safety;Site;Structure;success;Surface;symporter;System;Testing;Therapeutic;Therapeutic Effect;Therapeutic Index;Tight Junctions;Tissues;Toxic effect;transcytosis;transduction efficiency;Transfection;Translations;Tropism;ultrasound;uptake;vector;Ventricular;Viral Vector

PROJECT_TITLE: Ultrasound Cavitation for Facilitated Cardiac Transduction of AAV

STUDY_SECTION: TDPS

STUDY_SECTION_NAME: Therapeutic Development and Preclinical Studies Study Section[TDPS]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE The recent appreciation of memory CD8 T cell populations that strictly reside in tissues, where infections and cellular transformation occur, provides an exciting opportunity to create new approaches to enhance or modulate immunity in “tissue-tailored” immune responses. By identifying the unique transcriptional pathways and regulators of tissue-resident memory T cells and the distinct programming associated with different tissues, we will discover novel targets with the potential to inform strategic design of therapeutic and protective vaccines, the development of which are of crucial importance to human health.

PI_NAMEs: GOLDRATH, ANANDA W (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Acute;acute infection;Adhesions;antigen-specific T cells;Autoimmunity;Bacterial Infections;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Differentiation process;Cell Maintenance;Cells;Cellular biology;Characteristics;chemokine;chronic infection;Circulation;Collaborations;Contracts;Cues;cytokine;Cytoprotection;Dependence;design;Development;Disease;Down-Regulation;effector T cell;Environment;Epigenetic Process;functional adaptation;Gene Expression;gene regulatory network;Gene Targeting;Genes;Genetic Transcription;Genome;Goals;graft vs host disease;Health;Homing;Human;Immune;immune activation;immune function;Immune response;Immunity;Immunologic Memory;immunopathology;Immunosuppression;imprint;improved;in vitro Model;in vivo;Infection;Inflammatory Bowel Diseases;intraepithelial;kidney cell;knock-down;Leaky Gut;Liver;Lymphocyte;Lymphoid;Lymphoid Tissue;Maintenance;Malignant Neoplasms;Mediating;Memory;metaplastic cell transformation;Molecular;Mus;novel;novel strategies;Organ;Organism;overexpression;Overlapping Genes;pathogen;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Population;programs;proliferation potential;promoter;recruit;Regulation;Reporter;Repression;residence;Residencies;Resolution;response;Role;RUNX3 gene;secondary lymphoid organ;Signal Induction;Site;Small Intestines;Syndrome;T cell differentiation;T memory cell;T-Lymphocyte;Testing;Therapeutic;Tissue Model;tissue resident memory T cell;Tissues;transcription factor;Transcription Repressor;transcriptomics;Tretinoin;tumor growth;Up-Regulation;vaccine efficacy;vaccine strategy;Vaccines;Virus Diseases

PROJECT_TITLE: Tissue-specific adaptions to promote localized T cell memory

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Biotechnology;Congenital Structural Anomalies;Digestive Diseases;Genetics;Kidney Disease;Liver Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative: Autosomal Dominant Polycystic Kidney disease (ADPKD) results from insufficient functional amounts of PKD1/Polycystin-1, yet no approved therapy is available to increase Polycystin-1 nor prevent this disease from resulting in 5-10% of end-stage kidney disease in populations across the globe. We have identified that Polycystin-1 translation from PKD1 mRNA is dramatically blunted in vitro due to alternative translation of upstream open reading frames (uORFs) from the PKD1 5’UTR without which Polcystin-1 expression could be 3-4 times more. For this award we propose testing the role of uORF translation in ADPKD and therapeutic potential of blocking PKD1 uORF translation using humanized mouse models genetically-edited to lack uORF initation codons or steric inhibition of uORF translation with antisense oligonucleotides (ASOs).

PI_NAMEs: BESSE, WHITNEY ELISE (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: 5' Untranslated Regions;Abdominal Pain;Affect;Alleles;antagonist;Antisense Oligonucleotides;Autosomal Dominant Polycystic Kidney;Award;Bacterial Artificial Chromosomes;Biological;Biological Assay;Cell surface;Cells;clinical diagnosis;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Cyst;Cystic kidney;Data;Development;Disease;DNA Sequence Alteration;dosage;Dose;effective therapy;End stage renal failure;Endoplasmic Reticulum;Epithelial cyst;FDA approved;Genes;genome-wide;Genomics;Growth;Hepatectomy;Hepatic Cyst;Human;humanized mouse;Impairment;In Vitro;in vivo;Initiator Codon;Intervention;Investigation;Kidney;Kidney Failure;Laboratories;Liquid substance;Liver;liver transplantation;Luciferases;Messenger RNA;MicroRNAs;Modeling;Molecular Chaperones;Mouse Cell Line;mouse model;mRNA Expression;Mus;Mutation;novel;novel strategies;Nucleotides;oligonucleotide delivery;oligonucleotide therapeutics;Open Reading Frames;overexpression;Pathogenicity;patient subsets;Patients;Peptides;Persons;PKD1 gene;PKD2 protein;polycystic kidney disease 1 protein;polycystic liver disease;Population;prevent;PRKCSH protein;Production;Protein Biosynthesis;protein expression;Proteins;Publishing;Regulation;repaired;Repression;Role;Severity of illness;Site;Somatic Mutation;Testing;Therapeutic;therapeutic target;tolvaptan;transcription factor;Translating;translational potential;Translations;Vasopressin Receptor;Western Blotting;Work;XBP1 gene

PROJECT_TITLE: In vivo investigation of PKD1 upstream open reading frames as a therapeutic target in autosomal dominant polycystic kidney disease

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Clinical Research;Estrogen;Genetics;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_CITY: BURLINGTON

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: PROJECT NARRATIVE There are more than 2 million American women who have survived breast cancer for five or more years, and for whom risk of late recurrence is a never-ending concern. We propose to discover the first molecular test to predict a woman’s risk for late breast cancer recurrence. Such a test would allow risk stratification for initiating one of several new and emerging therapies to prevent late recurrence.

PI_NAMEs: AHERN, THOMAS PATRICK (contact)

PROGRAM_OFFICER_NAME: GALLICCHIO, LISA M

PROJECT_TERMS: adjuvant endocrine therapy;Adjuvant Therapy;Age;Agreement;American;American Society of Clinical Oncology;antagonist;Anti-estrogen Therapy;Apoptotic;Archives;assault;Attention;biobank;Biological;Biological Assay;Biological Markers;Breast Cancer Patient;breast cancer survival;Breast Cancer survivor;Breast Cancer Treatment;Calendar;cancer recurrence;Cell Death;Cell division;Cells;Characteristics;Clinical;Clinical Management;cohort;Cohort Studies;Collection;Data;demographics;design;Diagnosis;differential expression;Disease;Distant;Ensure;Environment;Estrogen receptor positive;Estrogen Receptors;evidence base;Face;follow-up;Formalin;gene discovery;Gene Expression;Gene Expression Profile;Genes;Genomics;Guidelines;Hand;Health;high risk;High Risk Woman;Hypoxia;Immunologic Surveillance;improved;indexing;Lead;Logistic Regressions;machine learning algorithm;machine learning model;Malignant Breast Neoplasm;Mammary Neoplasms;Medical Records;Menopausal Status;Menopause;Modeling;Molecular;molecular diagnostics;Molecular Epidemiology;mRNA Expression;National Comprehensive Cancer Network;Neoplasm Metastasis;new therapeutic target;next generation;Nonmetastatic;novel therapeutics;Operative Surgical Procedures;Paraffin Embedding;Pathology;Pathway interactions;Patients;Pattern;Pharmaceutical Preparations;Population Study;Postmenopause;prediction algorithm;predictive modeling;predictive panel;Premenopause;prevent;Primary Neoplasm;Process;prognostic assays;Prognostic Marker;prognostic model;prophylactic;Protac;Provider;Recommendation;Recording of previous events;Recurrence;Registries;Reproducibility;Risk;risk prediction;risk stratification;Sampling;screening;Signal Transduction;Specificity;Stage at Diagnosis;Testing;Time;Toxic effect;transcriptome;treatment adherence;treatment strategy;tumor;Tumor Tissue;Validation;Woman;Work

PROJECT_TITLE: Using gene expression to identify patients at high risk for late breast cancer recurrence

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BOSTON

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PHR: Project Narrative This project seeks to generate novel endochin-like quinolones optimized for use in new malaria elimination strategies focused on preventing transmission of Plasmodium parasites by Anopheles mosquitoes. Taking a holistic, bench-to-product approach comprising in vitro medicinal chemistry to in vivo efficacy studies and product prototyping, this 5-year project will test the full potential of delivering antimalarials to mosquitoes as a way to prevent malaria transmission, and will pave the way for full-scale epidemiological trials in the future.

PI_NAMEs: CATTERUCCIA, FLAMINIA  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: absorption;Africa;Africa South of the Sahara;Anopheles gambiae;Anopheles Genus;Anti-malarials;Antiparasitic Agents;Area;Artemisinins;atovaquone;base;Beds;Binding;Biological Assay;Bite;Collaborations;Combined Modality Therapy;Culicidae;Cytochrome bc1 Complex;Data;design;Development;Disease;Drug Kinetics;efficacy study;Electron Transport;Electron Transport Complex III;epidemiological model;Epidemiology;Exhibits;experimental study;Exposure to;Female;Fiber;Foundations;Future;Generations;Goals;Human;In Vitro;in vivo;Infection;inhibitor;innovation;Insecticide Resistance;Insecticides;Intervention;Leg;Malaria;malaria infection;malaria mosquito;Malaria prevention;malaria transmission;Mass Spectrum Analysis;Mediating;Methods;Mitochondria;Morbidity - disease rate;mortality;Mosquito Control;Multienzyme Complexes;mutant;next generation;novel;Outcome;oxidation;Parasite resistance;Parasites;Performance;Pharmaceutical Chemistry;Plasmodium;Plasmodium falciparum;Polyesters;Polyethylenes;Polymers;Population;predictive modeling;prevent;Prodrugs;product development;prototype;pyrethroid;Quinolones;Residual state;Resistance;Siblings;Side;Site;Solid;Stress;Structure;Structure-Activity Relationship;Surface;System;Testing;Textiles;Therapeutic;Time;Tissues;tool;trait;transmission blocking;transmission process;Ubiquinone;uptake;vector;vector control;Vertebral column

PROJECT_TITLE: From bench to bednet: Developing novel mitochondrial inhibitors for killing Plasmodium in the malaria mosquito

STUDY_SECTION: TVZ

STUDY_SECTION_NAME: Transmission of Vector-Borne and Zoonotic Diseases Study Section [TVZ]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurosciences

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because discovering the principles that permit nor- mal development of extraocular motor neurons is expected to increase understanding of the mecha- nisms responsible for eye movement disorders that disrupt vision. Therefore, the proposed research is relevant to the part of the NIH’s mission to increase fundamental knowledge of the mechanisms of diseases, disorders, and dysfunctions that impair health.

PI_NAMEs: SCHOPPIK, DAVID  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Affect;Anatomy;Atlases;Axon;behavior measurement;Behavioral;Biological Assay;Calcium;Candidate Disease Gene;candidate selection;candidate validation;CCRL2 gene;Cell Nucleus;Cephalic;Classification;clinical predictors;Collaborations;CRISPR/Cas technology;Dasen;Data;Date of birth;Development;developmental disease;differential expression;Disease;experimental study;Eye;Eye diseases;Eye Movements;Failure;Fiber;Fluorescent in Situ Hybridization;Foundations;Functional disorder;gaze;Gene Expression Profile;Gene Expression Profiling;gene function;Generations;Genes;Genetic;Genetic Determinism;Genetic Transcription;Hereditary Disease;Heritability;Human;Image;Impaired health;Knowledge;Label;Laboratories;loss of function;Maps;Measures;Mediating;Mission;Modeling;Molecular;motor disorder;motor neuron development;Motor Neurons;Muscle;Mutagenesis;Mutation;nerve supply;neuronal circuitry;Neurons;Ocular Motility Disorders;oculomotor;Phenotype;Play;Population;predictive test;Public Health;Research;Resources;response;Role;Specific qualifier value;Spinal;Strabismus;System;Testing;Time;transcriptomics;Transgenic Organisms;United States National Institutes of Health;Vertebrates;Vision;Vision Disorders;Work;Zebrafish

PROJECT_TITLE: Determinants of extraocular motor neuron subtype diversity

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Data Science;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Prevention

ORG_CITY: IOWA CITY

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative This work can positively impact public heath by providing real time diagnosis and prognosis determination and decision support for clinical patients with Takotsubo Syndrome with more objective and innovative spatiotemporal deep learning prediction models based on routinely available bedside imaging approaches. This proposed research is relevant to the NIH mission as it enables frontline clinicians to resolve time-sensitive diagnostic and therapeutic dilemmas and obtain advanced bioimaging markers to develop personalized treatment in patients with acute cardiovascular disorders.

PI_NAMEs: LIU, KAN ;WANG, YI ;WU, XIAODONG  (contact)

PROGRAM_OFFICER_NAME: HSU, LI-YUEH

PROJECT_TERMS: 3-Dimensional;Acute;Acute myocardial infarction;Address;Adverse event;Algorithms;Artificial Intelligence;Attention;bioimaging;Board Certification;Cardiac;Cardiovascular Diseases;Characteristics;Classification;Clinical;clinical decision support;clinical diagnosis;clinical practice;clinical predictive model;Computer Analysis;convolutional neural network;Data;Data Set;data visualization;deep learning;deep learning model;deep neural network;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic tool;diagnostic value;Dimensions;Discrimination;Echocardiography;empowerment;Engineering;Evaluation;Foundations;Functional disorder;Goals;Grouping;Human;Image;imaging approach;imaging biomarker;Impairment;improved;inattentional blindness;Individual;innovation;Institution;inter-institutional;Investigation;Judgment;Learning;learning network;Machine Learning;Maps;Mechanics;Metadata;Mission;Modeling;Motion;Movement;Myocardial;Myocardium;neural model;Neural Network Simulation;noninvasive diagnosis;novel;open source tool;Outcome;Patients;Pattern;Perception;personalized medicine;Phenotype;Population;precision medicine;predictive modeling;prevent;Prevention strategy;Primary Prevention;Prognosis;prognostic;prognostication;Public Health;Reader;real-time images;recurrent neural network;Research;Research Project Grants;Risk Reduction;scale up;Secondary Prevention;Software Validation;Solid;spatiotemporal;Stress cardiomyopathy;support tools;Syndrome;Techniques;Therapeutic;therapeutically effective;Time;tool;Training;Triage;Two-Dimensional Echocardiography;United States National Institutes of Health;Validation;Vendor;Visual;Work

PROJECT_TITLE: Implications of Spatiotemporal Deep Learning Neural Networks in Echocardiographic Diagnosis and Prognostication of Takotsubo Syndrome

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Clinical Research;Genetics;Pediatric;Rheumatoid Arthritis

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE In some forms of chronic inflammatory arthritis, T cells provide excessive help to B cells leading to local autoantibody production in the joints. Using samples from children with arthritis, this study aims to better understand how regulatory T cells restrain these aberrant T cell-B cell responses that occur in inflamed tissues. Our research may provide insights into how to control inflammation and better treat patients with arthritis and other autoimmune conditions characterized by autoantibody formation.

PI_NAMEs: HENDERSON, LAUREN A (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Adult;Affect;Antibodies;Antibody Formation;Antinuclear Antibodies;Arthritis;Autoantibodies;Autoimmune Diseases;Automobile Driving;Award;B-Lymphocytes;biobank;Bioinformatics;Biological Assay;Biology;Blood;BLR1 gene;Candidate Disease Gene;career;Cell Communication;Cell Lineage;Cell Maturation;Cells;Child;ChIP-seq;Chronic;Chronic Childhood Arthritis;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Coupled;CTLA4 gene;CXCL13 gene;cytokine;Data;Development;Disease;early onset;Ensure;Exposure to;FOXP3 gene;Funding;Gene Deletion;Gene Expression;gene network;Generations;Genetic Transcription;Helper-Inducer T-Lymphocyte;Immunoglobulin Class Switching;Immunologics;Immunology;Inflammation;Inflammatory Arthritis;innovation;insight;joint inflammation;Joints;Laboratories;Liquid substance;lymph nodes;lymphocyte proliferation;lymphoid organ;Measures;Mediating;metabolic abnormality assessment;Metabolism;Methylation;multiple omics;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;overexpression;Pathogenicity;Pathway interactions;Patients;Peripheral;peripheral blood;Plasmablast;Population;Population Control;Positioning Attribute;Production;programmed cell death protein 1;programs;Proliferating;Proteins;Regulatory Pathway;Regulatory T-Lymphocyte;Research;Research Personnel;Research Proposals;Resources;response;restraint;Role;Sampling;single-cell RNA sequencing;Synovial Fluid;System;T cell differentiation;T cell receptor repertoire sequencing;T-Lymphocyte;T-Lymphocyte Subsets;TCF Transcription Factor;Technology;Testing;Therapeutic;Tissues;Tonsil;transcription factor;transcriptomics

PROJECT_TITLE: T peripheral regulatory cells as modulators of T cell-B cell interactions in arthritis

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cannabidiol Research;Cannabinoid Research;Clinical Research;Complementary and Integrative Health;Electronic Nicotine Delivery Systems;Lung;Natural Products;Prevention;Therapeutic Cannabinoid Research;Tobacco

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE Cannabidiol (CBD)-derived tetrahydrocannabinol (THC) products, such as Delta-8-THC (∆8-THC) are legal and increasingly used in vaping devices. Vaping-induced oxidation of CBD, ∆8-THC, and other THC isomers is likely enhanced by pro-oxidant constituents in the liquids, such as metals and flavoring chemicals. Studies outlined in this application will link pro-oxidant constituents in THC vaping liquids and vaping-induced oxidation products, with modified biological functions in epithelial cells using in vitro and in vivo models, thus providing novel, urgently needed, mechanistic information on vaping THC products.

PI_NAMEs: JASPERS, ILONA  (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Acetates;Address;adduct;aerosolized;Aerosols;Affect;airway epithelium;Alkynes;analog;Biological;Biological Markers;Biological Process;Blood Pressure;Breathing;bronchial epithelium;Cannabidiol;Cannabinoids;cellular targeting;chemical stability;Chemicals;Chemistry;Chromatography;Computer Models;cycloaddition;Data;Data Analyses;Devices;Dose;Electronic cigarette;electronic liquid;Epidemic;Epithelial Cells;Event;Exposure to;Farm;Flavoring;functional group;Gene Expression;Grant;Health;Heart Rate;Heavy Metals;Hemp;Human;Immune;Immune signaling;In Vitro;in vivo;in vivo Model;Inhalation;Isomerism;Knowledge;Laboratories;Legal;Link;Liquid substance;lung health;Marijuana;marijuana use;Measures;Metabolic;metabolomics;Metals;Methods;microbial products;Modification;Multiomic Data;multiple omics;Nicotine;novel;Outcome;Oxidants;oxidation;Pathway interactions;Patients;Pesticides;Post-Translational Protein Processing;prevent;Proteins;Proteomics;Public Health;public health relevance;Publishing;Quinones;Reactive Oxygen Species;Reporting;Research;respiratory;Respiratory Mucosa;response;Risk;Safety;Sampling;Signal Transduction;Structure of mucous membrane of nose;Sulfhydryl Compounds;Symptoms;System;Techniques;Terpenes;Tetrahydrocannabinol;THC exposure;Tissues;tool;Toxic effect;transcriptome sequencing;transcriptomics;Transition Elements;Translating;Unconscious State;vaper;vaping;vaping associated lung injury;vaping THC;vaporization;Vitamin E Acetate;Vomiting

PROJECT_TITLE: Health effects of cannabidiol vaping products

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Orphan Drug;Ovarian Cancer;Precision Medicine;Prevention;Rare Diseases;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE We have identified a promising new active combination, ATR and BET family protein inhibition, that exploits a common genetic alteration, the ARID1A mutation. This mutation is found in ~50% of clear cell ovarian cancers (CCOC), which lack effective therapies. The genomic and proteomic studies described herein will validate ARID1A mutation as a predictive biomarker for ATRi-BETi treatment of CCOC and will also identify additional predictive biomarkers of response to further optimize this therapy for future clinical trials.

PI_NAMEs: BROWN, ERIC J;SIMPKINS, FIONA  (contact)

PROGRAM_OFFICER_NAME: SONG, MIN-KYUNG H

PROJECT_TERMS: Address;Affect;Animal Model;ARID1A gene;Biological Assay;Biological Markers;biomarker signature;cancer cell;Cancer Patient;candidate marker;Cell model;Cell Survival;Cells;chemotherapy;Chromatin;Clinic;Clinical;Clinical Trials;Clinical Trials Cooperative Group;cohort;Combined Modality Therapy;Computer Models;Data;deep learning;Dependence;design;Dimensions;DNA;DNA biosynthesis;DNA Damage;DNA Repair;DNA replication fork;Dose;effective therapy;Effectiveness;endometriosis;Epigenetic Process;Family;first-in-human;Future;Gene Expression;Gene Expression Alteration;Gene Mutation;Gene Proteins;Genes;Genetic Transcription;Genome;Genomics;Goals;High Prevalence;Human;human model;Laboratories;Libraries;Link;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;member;Molecular;Molecular Profiling;molecular site;Mutate;Mutation;next generation;novel;novel marker;novel therapeutics;Oncology Group;Outcome;Ovarian Clear Cell Tumor;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacotherapy;Phase;Phase Ib Clinical Trial;preclinical study;predicting response;Prediction of Response to Therapy;predictive marker;prevent;Protein Family;Protein Inhibition;Proteomics;Recurrence;Research;Research Personnel;Resistance;response;response biomarker;Running;Sample Size;Sampling;Selection for Treatments;Serous;standard of care;synergism;Testing;transcriptomics;treatment optimization;treatment response;tumor;Tumor Suppressor Proteins;tumor xenograft;Validation

PROJECT_TITLE: Developing biomarkers of response for a new therapy in ovarian cancer

STUDY_SECTION_NAME: Molecular Cancer Diagnosis and Classification Study Section[MCDC]


NIH_SPENDING_CATS: Digestive Diseases;Liver Disease

ORG_DEPT: PATHOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: PROJECT NARRATIVE: This project explores the fate of fatty acid substrate in organs impacted by primary mitochondria disease - specifically by a major defect in oxidative phosphorylation (oxphos) - and the potential consequences on the adaptive responses to the oxphos deficiency. We will test the hypothesis that substrate metabolism in an organism with primary mitochondrial disease in muscle is rewired such that the liver and heart each acquire a greater role to take up and to oxidize fatty acids, thereby mitigating lipid-induced stress responses in oxphos-deficient muscle while providing the liver with a gluconeogenic substrate. These studies are expected to provide insight into how multi- organ compensation could mitigate a lipid burden and reductive stress in oxphos-deficient muscle, which is a major issue that is understudied, and to uncover novel regulation of the stress responses to mitochondrial dysfunction.

PI_NAMEs: SEIFERT, ERIN  (contact);SNYDER, NATHANIEL W.

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: Acetyl-CoA Carboxylase;Acyl Coenzyme A;Adipose tissue;Affect;arm;ATP Synthesis Pathway;biological adaptation to stress;Bolus Infusion;Carbon;Cells;Cellular Stress;Circulation;Closure by clamp;Compensation;Competence;Couples;Coupling;Defect;Dependence;Dietary Fats;Dyslipidemias;endoplasmic reticulum stress;Enzymes;Exercise;Fasting;Fatty acid glycerol esters;fatty acid oxidation;Fatty Acids;Feedback;feeding;FGF21 gene;Fiber;fibroblast growth factor 21;flexibility;Glucose;glucose analog;Glucose Clamp;glucose disposal;glucose production;glucose uptake;Glycolysis;Goals;Heart;Hepatic;High Fat Diet;Human;Hyperinsulinism;in vivo;Incidence;insight;Insulin;Insulin Resistance;insulin signaling;Isotopes;knock-down;Label;Lipids;Liver;Measures;Mediating;Metabolic;Metabolism;Mitochondria;Mitochondrial Diseases;mitochondrial dysfunction;Mitochondrial Myopathies;Modeling;Mus;Muscle;Muscle Mitochondria;novel;novel strategies;Organ;Organism;oxidation;Oxidative Phosphorylation;Patients;Phosphate Carriers;Plasma;potential biomarker;Process;Production;protein expression;Proteins;Pyruvate Dehydrogenase Complex;Quality Control;Radiolabeled;Regulation;response;Rest;Role;Serum;Signal Transduction;Skeletal Muscle;Stress;Testing;Tracer;Triglycerides;uptake

PROJECT_TITLE: Relevance of fatty acid handling in the adaptive response to mitochondrial dysfunction

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: DEL MAR

ORG_NAME: VIROGENICS, INC.

PHR: Narrative Currently there are no drugs that significantly alter the clinical hallmarks of Alzheimer's disease, such as impaired memory and loss of executive function. We aim to develop a novel compound that is both neuroprotective and able to harness the good aspects of the brain's immune system in order to prevent the loss of brain function in Alzheimer's disease. If successful in clinical trials, this approach could prove beneficial for the treatment not only of Alzheimer's disease but also a number of other age-related disorders.

PI_NAMEs: MAHER, PAMELA ANNE;RASCHKE, WILLIAM C (contact)

PROGRAM_OFFICER_NAME: REFOLO, LORENZO

PROJECT_TERMS: Address;Adult;Affect;age-related disease;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease therapeutic;Animals;associated symptom;Behavioral Symptoms;Brain;Canis familiaris;Characteristics;Clinical;Clinical Trials;Cognition;cognitive benefits;Conduct Clinical Trials;Data;Detection;Disease;Dose;drug candidate;drug development;Drug Interactions;Evaluation;executive function;Fatty Acids;Genetic;Goals;Health;Homeostasis;Human;human subject;Immune system;Impairment;improved;Lipid Peroxidation;Lipids;Maleates;manufacture;Measures;Memory impairment;Metabolism;method development;mild cognitive impairment;Mitochondria;Monitor;mouse model;neuroinflammation;neuroprotection;No-Observed-Adverse-Effect Level;novel;novel strategies;novel therapeutic intervention;Oral Administration;Organ;Parents;Pathologic Processes;Pharmaceutical Preparations;pharmacologic;phase 2 designs;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Plasma;prevent;Process;Rattus;Reporting;restoration;Safety;Scientist;Senile Plaques;Series;small molecule;small molecule therapeutics;Sodium Chloride;Testing;Therapeutic;Toxicology;treatment duration;Update;Validation;volunteer

PROJECT_TITLE: Long-term, non-clinical toxicology for advancing CMS121 to Phase 2 trials for AD

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-J (O1)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Digestive Diseases;Prevention;Substance Misuse

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Here we study whether serum fatty acid ethyl esters (FAEEs) may be good biomarkers for diagnosing and predicting the severity of alcoholic pancreatitis. We will also study how alcohol and adipose tissue affect FAEEs, and alcohol or FAEEs in turn affect pancreatitis severity compared to their parent fatty acids.

PI_NAMEs: SINGH, VIJAY PREM (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acinus organ component;acute pancreatitis;Adipocytes;Adipose tissue;Admission activity;Affect;Alcohol consumption;Alcoholic Pancreatitis;Alcohols;aqueous;Area Under Curve;Biological Markers;Blood;Blood Cells;Carbon;Cardiolipins;cell injury;Cell membrane;cell type;Cells;chronic pancreatitis;Collection;Coumarins;Counseling;Databases;Diagnosis;diagnostic biomarker;Disease;Endothelial Cells;Endothelium;Esters;Ethanol;Etiology;Fat necrosis;Fatty acid glycerol esters;Fatty Acids;Generations;Guidelines;Half-Life;Human;Hydrophobicity;imaging modality;Inflammation;injured;Injury;kidney cell;Lipids;Mediating;Membrane;Methods;Mitochondria;Modeling;monomer;Mus;Necrosis;Noise;non-alcoholic;Nonesterified Fatty Acids;novel;Organ failure;Pancreas;Pancreatic Injury;Pancreatitis;Parents;Pathogenesis;Patients;Phospholipase;phospholipase D2;Phospholipids;Physical Chemistry;potential biomarker;problem drinker;Prognostic Marker;prognostic value;prospective;Radiology Specialty;Recurrence;Reporting;Risk;Risk Reduction;Role;Sampling;Serum;Severities;Shock;sobriety;Source;Testing;uptake;Visceral fat;Voltage-Dependent Anion Channel

PROJECT_TITLE: Biomarkers and pathogenesis of Alcoholic acute pancreatitis

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative  Inputting and editing text, which constitutes over 40% of one’s smartphone usage, remains a challenge for blind smartphone users vis-à-vis their sighted counterparts, with studies showing that blind users typing speed on smartphones is an order of magnitude slower compared to sighted users. This project will research and develop a new generation of intelligent text input and editing methods that will substantially enhance both the ease of use and efficiency of these operations and thereby bridge the gap in user experience between blind smartphone users and sighted users. More importantly, the intelligent text input and editing methods that will merge from this project will eliminate any barriers to productivity of blind smartphone users and empower them to utilize the power and connectivity of these devices to fully participate in this digitized economy.

PI_NAMEs: BI, XIAOJUN  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TITLE: Intelligent Text Input and Editing Methods on Smartphones for Blind Users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative A tremendous problem in molecular therapeutics is the difficulty in targeting specific cell types or diseased cells within healthy tissue due to the lack of efficient delivery methods carriers that do not provoke an immune response or evade endosomal capture. In this project, new technology will be developed to utilize extracellular vesicles (EVs) as molecular cargo to deliver molecular therapeutics and to uncover the EV-cell interaction and delivery. This project aims to demonstrate the proof-of-principle of an EV-mediated therapeutic delivery system applicable to diverse diseases awaiting targeted therapeutic delivery for clinical application into EGFR-type tumors resistant to existing therapeutics by targeted delivery and efficacy in vivo.

PI_NAMEs: HARADA, MASAKO  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Acceleration;Adverse event;Animals;antibody mimetics;antitumor effect;Binding;Biodistribution;Biology;cancer cell;cancer therapy;Cell Communication;Cell Line;cell type;Cells;Clinical;clinical application;Clinical Trials;cytotoxicity;Data;design;Development;Disease;Drug Delivery Systems;Drug resistance;Drug Targeting;drug testing;effectiveness evaluation;Embryo;empowerment;Encapsulated;Endosomes;Engineering;Epidermal Growth Factor Receptor;established cell line;ex vivo imaging;experience;extracellular vesicles;Foundations;Gene Delivery;Generations;Genes;Genetic Engineering;Goals;Human;Immune Evasion;Immune response;Immunocompetent;immunogenic;immunogenicity;improved;In Vitro;in vivo;in vivo evaluation;in vivo imaging;interest;kidney cell;Knowledge;Ligands;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methods;microRNA delivery;MicroRNAs;Molecular;Monitor;mouse model;mutant;nanoparticle delivery;Neoplasm Metastasis;new technology;Organ;Outcome;Pathology;Pathway interactions;Play;Pre-Clinical Model;Production;protein protein interaction;protein transport;Receptor Cell;Reproducibility;Resistance;response;RNA Transport;Role;Route;Safety;Speed;Standardization;Surface;System;targeted delivery;targeted treatment;Testing;Therapeutic;therapeutic development;therapeutic evaluation;therapeutic miRNA;therapeutic target;Tissues;Transgenic Mice;Transgenic Organisms;Translational Regulation;Treatment Efficacy;tumor;Tumor Biology;tumor progression;tumor specificity;Tumor Suppression;Tumor Suppressor Proteins;Untranslated RNA;uptake;Validation

PROJECT_TITLE: Developing extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project narrative. Failure to correctly organize the genome within the cell is associated with a variety of human diseases. This project details the development a new method to map how genomes are folded within a cell. The new method will allow important questions to be investigated with unprecedented detail - allowing new insights into key elements of human disease.

PI_NAMEs: WHITEHOUSE, IESTYN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: 3-Dimensional;Affect;affinity labeling;Antibodies;Beak;Binding;Binding Proteins;Biological Assay;Biological Process;Buffers;Cells;Chromatin;chromatin immunoprecipitation;Chromosome Mapping;Chromosome Structures;Chromosomes;Complex;Complex Mixtures;crosslink;Data;Development;DNA;DNA Ligation;DNA Repair;Elements;embryonic stem cell;Epitopes;Event;experimental study;Failure;Genetic Transcription;Genome;Genome Mappings;Genomics;human disease;improved;in vivo;Individual;insight;Knowledge;Label;Ligation;Mammalian Cell;mammalian genome;Maps;Measurement;Mechanics;Meiosis;Methodology;Methods;Modeling;Modification;Mus;nanobodies;Nature;novel;novel strategies;Nucleosomes;Paste substance;physical separation;Play;Protein Engineering;Proteins;Reaction;repaired;Reporting;Resolution;Role;Saccharomycetales;Sampling;segregation;single molecule;System;Temperature;Testing

PROJECT_TITLE: Proximity Copy Paste: A methodology for single-molecule analysis of chromosome structure

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Nutrition;Obesity;Polycystic Ovary Syndrome (PCOS);Prevention;Women's Health Research

ORG_CITY: JACKSON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Polycystic ovary syndrome (PCOS) is a common health condition that affects about 10% of women of reproductive age. Women with PCOS have elevated levels of the male androgen hormone testosterone and a high prevalence of obesity, insulin resistance, and elevated blood pressure, which lead to cardiovascular disease. This proposed research will shed light on novel androgens-mediated mechanisms that will translate into effective and safe therapeutic agents to treat the cardio-metabolic complications frequently found in women with PCOS.

PI_NAMEs: YANES CARDOZO, LICY LORENA (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: 3-Dimensional;ACE2;Address;Adipocytes;adipokines;adiponectin;Adipose tissue;Adverse effects;Affect;Age;aged;Agonist;androgen excess;Androgens;Angiotensin II;Angiotensins;Animal Model;Applications Grants;arm;autocrine;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure reduction;blood pressure regulation;Body Weight decreased;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cell Culture Techniques;clinically relevant;comparison control;Control Groups;Data;Diagnosis;Enalapril;Endocrine System Diseases;Enzyme Inhibition;Fatty acid glycerol esters;feeding;Female;Functional disorder;Goals;Health;High Prevalence;Hormones;Human;Hyperandrogenemia;Image;Impairment;implantation;improved;In Vitro;in vivo;innovation;Insulin;Insulin Resistance;Knockout Mice;Knowledge;Laboratories;Lead;male;Measurement;Measures;Mediating;Metabolic;Methods;Modeling;Molecular;Molecular Target;Mus;new therapeutic target;novel;novel therapeutics;Obesity;ovarian dysfunction;paracrine;Pathway interactions;Peptides;Peptidyl-Dipeptidase A;pharmacologic;Physiological;Plasma;Play;Polycystic Ovary Syndrome;prevent;Rattus;receptor;Receptor, Angiotensin, Type 1;Renin-Angiotensin System;reproductive;Research;Research Proposals;response;Role;Signal Transduction;Stanolone;subcutaneous;System;Testing;Testosterone;Therapeutic Agents;therapeutically effective;Thinness;three dimensional cell culture;Translating;Visceral;Weight Gain;Woman

PROJECT_TITLE: Role of obesity in blood pressure regulation and insulin resistance in Polycystic Ovary Syndrome

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: OPHTHALMOLOGY

PHR: A balanced regulation of complement is necessary to prevent inflammation. We will assess the consequences of genetic variation to disturb this balance and lead to disease.

PI_NAMEs: ATKINSON, JOHN ;ROHRER, BAERBEL ;STAMBOLIAN, DWIGHT EDWARD (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Adult;Affect;Age of Onset;Age related macular degeneration;Aging;Alleles;Apical;Apoptotic;autocrine;Biological Assay;Biological Models;Cell Differentiation Induction;Cell Line;Cell model;Cell Physiology;Cells;cigarette smoke;Code;Complement;Complement Activation;complement pathway;complement system;Complex;cytokine;Data;Deposition;Disease;Drusen;Ensure;Environment;Epithelial Cells;epithelial stem cell;Epithelium;equilibration disorder;Event;experimental study;Exposure to;extracellular;Extracellular Matrix Proteins;extracellular vesicles;Functional disorder;Future;Gene Activation;gene complementation;Gene Expression;Gene Expression Profile;Genetic;genetic association;Genetic Complementation Test;genetic regulatory protein;Genetic Transcription;genetic variant;Genetic Variation;genome wide association study;Genotype;Glomerulonephritis;Goals;Hemolytic-Uremic Syndrome;Homeostasis;Human;human disease;induced pluripotent stem cell;Infection;Inflammation;Invaded;Kidney;Knowledge;Location;Lung;Maintenance;Mediating;Membrane;Messenger RNA;microorganism;Modeling;monolayer;Morphology;Natural Immunity;Outcome;paracrine;Pathologic;Pathway interactions;Patients;pigment epithelium-derived factor;Play;prevent;Protein Analysis;Protein Secretion;Proteins;Proteolysis;Proteome;Publishing;receptor;Regulation;Reporting;Resistance;response;risk variant;RNA;Role;Scanning Electron Microscopy;Side;single-cell RNA sequencing;Smoke;Stress;stressor;Structure of retinal pigment epithelium;System;Testing;therapeutic target;Variant;Vascular Endothelial Growth Factors

PROJECT_TITLE: Functional Analysis of Complement Variants in a Genotyped iPSC Epithelial Cell Model System

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: NARRATIVE Visual disorders such as glaucoma and macular degeneration affect millions of Americans and lead to billions of dollars in health care costs. Eye movements are a critical part of vision, yet most visual disorders are studied outside the context of eye movements. To accelerate the translation of experimental results to clinical settings where eye movements predominate, this project seeks to understand how the brain coordinates vision and eye movement.

PI_NAMEs: MAYO, JOSEPH PATRICK (contact)

PROJECT_TERMS: Acceleration;active vision;Address;Affect;American;Anatomy;Animals;Area;Behavior;Bilateral;Brain;Brain region;Cerebral hemisphere;Clinical;Clinical Treatment;Cognition;Cognitive;Consensus;Data;Decision Making;Disparate;Dissection;Exhibits;experimental study;Eye;Eye Movements;Fire - disasters;flexibility;frontal eye fields;frontal lobe;Future;Glaucoma;Goals;Health Care Costs;Individual;insight;Knowledge;Laboratories;Learning;Link;Macular degeneration;Measurement;Measures;Mediating;Modeling;Monkeys;Motor;motor behavior;Motor Neurons;Movement;neural circuit;Neural Pathways;neuromechanism;Neurons;neuroregulation;novel;oculomotor;Outcome;Play;Population;Positioning Attribute;Prefrontal Cortex;Primates;Property;Research;response;Role;Saccades;scale up;Sensory;Signal Transduction;Target Populations;Testing;Therapeutic;Time;Training;Translations;vector;Vision;Vision Disorders;Visual;Visual attention;visual cognition;Visual Fields;visual information;visual motor;Visual Perception;visual processing;visual tracking;visual-motor integration;Work

PROJECT_TITLE: Multi-scale Dissection of Frontal Lobe Circuits for Interacting Eye Movements

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: NEW YORK

PHR: PROJECT NARRATIVE Dysphonia associated with vocal fold atrophy is a substantive clinical challenge and current treatment approaches are limited. This proposal will interrogate signaling events associated with atrophy with an emphasis on the SMAD family of proteins. These proteins have been implicated in the development of mucosal fibrosis in the vocal folds and cross-talk between the mucosa and muscle is implicated in atrophic processes in this complex system.

PI_NAMEs: BRANSKI, RYAN COMFORT (contact)

PROGRAM_OFFICER_NAME: KOPF, LISA MARIE

PROJECT_TERMS: Acute;Address;American;Anatomy;Annual Reports;Architecture;Area;Asthma;Atrophic;autocrine;Automobile Driving;Benign;Biochemical;Biological Phenomena;Biological Process;Catabolism;Categories;cell type;Choristoma;Chronic;Chronic Obstructive Pulmonary Disease;Classification;Clinical;Coculture Techniques;Complex;Data;Development;Diagnostic Specificity;Direct Costs;disability;Disease;Distal;Dysphonia;Environment;Etiology;Event;falls;Family;Fibroblasts;Fibrosis;Functional disorder;GDF8 gene;Genes;Genetic Transcription;Growth and Development function;In Situ;In Vitro;in vivo;Injury;innovation;insight;interest;Investigation;Laboratories;Lamina Propria;Laryngeal Diseases;Laryngeal muscle structure;Larynx;Lesion;Literature;Macrophage;Maintenance;Mediating;Mediator;member;Modeling;molecular scale;Mucous Membrane;Mus;Muscle;Muscle Cells;Muscle Development;Muscle Fibers;muscle physiology;Muscle Tension;Muscular Atrophy;Myoblasts;nerve injury;neuromuscular;Nodule;Nomenclature;novel;Outcome;paracrine;Paralysed;Paresis;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Phenotype;Polyps;prevent;Process;Protein Family;Proteins;Proteomics;Rattus;Recurrent Laryngeal Nerve;Regulation;Resistance;response;response to injury;RNA;Role;Signal Transduction;Signaling Protein;Skeletal Muscle;skeletal muscle growth;Smad Proteins;Standardization;Structure;System;Therapeutic;Thyroarytenoid Muscle;Tissues;transcriptome sequencing;Transforming Growth Factor beta;Treatment Efficacy;treatment strategy;Up-Regulation;vocal cord;Voice;Voice Disorders;Work

PROJECT_TITLE: Mechanisms of voice disorders associated with vocal fold atrophy

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PHR: Project narrative  RB1 is a tumor suppressor gene that is frequently mutated in various tumors, including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Despite extensive studies of pRb family proteins, a therapeutic approach that specifically targets defects in this tumor suppressor is currently not available, underscoring the need for alternative strategies that can identify new targets for cancers with inactivated RB1. We propose to identify a pair of FDA-approved drugs targeting synthetic lethal partners of RB1 to develop a novel personalized therapy for RB1-mutated tumors.

PI_NAMEs: PARKHITKO, ANDREY A (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Apoptosis;Automobile Driving;Biology;cancer cell;Cancer cell line;cancer type;Cell Aging;Cell Death;Cell Death Induction;Cells;Clinical Trials;CRISPR/Cas technology;Defect;Drosophila eye;Drosophila genus;Drug Combinations;Drug Targeting;Drug usage;experimental study;Eye;FDA approved;Future;Genes;Genetic Screening;Growth;high throughput screening;Human;Immunodeficient Mouse;improved;innovation;insight;Intestines;Knowledge;Lethal Genes;Libraries;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;metabolomics;mutant;Mutate;Neoplasm Metastasis;novel;Oncogenic;Organ;Osteosarcoma;Pathway interactions;Patients;personalized approach;personalized medicine;Pharmaceutical Preparations;preservation;Proliferating;Protein Family;RB1 gene;Retinoblastoma;Retinoblastoma Protein;RNA Splicing;Sampling;senescence;small cell lung carcinoma;small molecule;stem cells;synthetic lethal interaction;Testing;Therapeutic;transcriptomics;Translating;translational impact;triple-negative invasive breast carcinoma;tumor;tumor growth;Tumor Suppressor Genes;Tumor Suppressor Proteins;tumor xenograft;Work

PROJECT_TITLE: Combined targeting of synthetic lethal partners in RB1-deficient cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-V (O1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The genome of the preimplantation embryo is fragile, resulting in detrimental genetic change that can cause the demise of the embryo, or disease. The research proposed will lead us to understand why this occurs, and ultimately, how the frequency of these adverse outcomes might be reduced.

PI_NAMEs: EGLI, DIETER MEINRAD (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adult;adverse outcome;Affect;Aneuploidy;Animal Model;Area;Biological Models;blastocyst;Cattle;Cell Cycle;Cell division;Cells;Chromosome abnormality;Chromosome Breakage;Chromosome Fragile Sites;Chromosome Fragility;Data;de novo mutation;Defect;demethylation;Development;Disease;DNA;DNA biosynthesis;DNA Damage;DNA replication fork;DNA replication origin;DNA Replication Timing;DNA Transposable Elements;Embryo;embryo stage 2;Embryonic Development;Epigenetic Process;epigenome;Exclusion;Female;fly;Frequencies;Genes;genetic information;Genetic Transcription;Genetic Variation;Genome;genome integrity;Genomic Instability;Genomic Segment;Health;histone demethylase;histone methylation;Histones;Human;human model;Injections;innovation;insight;male;Mammals;Maps;Measures;Metabolic;Mitosis;Molecular;mouse model;Mus;Mutation;Neurons;Outcome;Pattern;Persons;pharmacologic;Pre-implantation Embryo Development;prevent;Rana;replication stress;Replication-Associated Process;Research;RNA-Directed DNA Polymerase;sex;Single-Stranded DNA;Site;Somatic Cell;Source;Speed;Testing;tool;Work;zygote

PROJECT_TITLE: Causes and Consequences of DNA Replication Stress in the Mammalian Preimplantation Embryo

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Urine drug testing (UDT) is an integral aspect of opioid use disorder treatment, yet no universal standards exist for how it should be used in clinical practice. The lack of clear guidance may result in inappropriate testing or missed opportunities to guide clinical care. The purpose of this project is to examine the use of UDT in a large, real-world population and assess the attitudes, knowledge, and practices of clinicians who order UDT.

PI_NAMEs: SALONER, BRENDAN K (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: Abstinence;addiction;Address;Adherence;American;Attitude;care outcomes;Caring;Categories;Characteristics;Clinic;Clinical;clinical care;clinical practice;Cocaine;Consensus;court;Data;Databases;Decision Making;Diagnosis;Disparate;drug testing;evidence base;evidence based guidelines;experience;Expert Opinion;follow-up;Foundations;Frequencies;Goals;Grant;Guidelines;Hospitalization;improved;Information Systems;Intake;Interest Group;Interview;Knowledge;Laboratories;Laws;Lead;Learning;Legal;Link;Matched Group;Measures;medication for opioid use disorder;Medicine;Methadone;Modeling;Monitor;non-opioid analgesic;Opioid;opioid treatment program;opioid use;opioid use disorder;participant enrollment;Patient Care;Patient Care Planning;Patient Self-Report;Patient-Centered Care;Patients;Pattern;Perception;Pharmaceutical Preparations;Phenotype;Policies;Population;Pragmatic clinical trial;Prevalence;Process;Process Measure;Professional Organizations;provider factors;Public Health;Recommendation;Recovery;recruit;Recurrence;Regulation;Research;Resources;response;Sampling;Services;Societies;Specimen;substance use;Supervision;Surveys;Test Result;Testing;Time;Training;Urine;Variant;Work

PROJECT_TITLE: Establishing an Evidence Base to Increase the Utility of Urine Drug Testing in Opioid Use Disorder Treatment.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-B (90)]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE Cerebellar involvement in dysmetric reach movements provides a window into ethologically relevant kinematic features that can be studied across species. This proposal will use experimental approaches to test theories of early cerebellar computations that guide movement endpoint precision in practice. With the long-term goal of better linking actions to circuit functions, this has the potential to better inform us about where and when to apply therapeutic interventions in cases of injury or disease to the motor system.

PI_NAMEs: NGUYEN, KATRINA  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Spatiotemporal encoding of goal-directed reaching across early cerebellar circuitry

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Behavioral and Social Science;Digestive Diseases;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hepatitis;Hepatitis - C;Infectious Diseases;Liver Disease;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Substance Misuse;Women's Health Research

ORG_CITY: ORLANDO

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Women who use drugs have a high risk of sexually transmitted infections (STIs) and related adverse sexual and reproductive health outcomes, and treating drug use could reduce substance use and sexual risk behavior while also increasing STI/HIV testing uptake, which in turn may ultimately reduce STI risk. The goal of the proposed research is to measure the associations between drug treatment and STI incidence among women who use drugs, evaluate the potential mediating pathways, and examine whether individual, social, and structural factors may modify these associations. Results of this research will inform targets for actionable interventions to improve women’s health, reduce morbidity and mortality, and address inequities in drug treatment and sexual and reproductive health.

PI_NAMEs: SCHEIDELL, JOY DANIELLE (contact)

PROGRAM_OFFICER_NAME: LEE-WINN, ANGELA EUNJI

PROJECT_TERMS: access disparities;Address;adverse birth outcomes;Adverse effects;Affect;Age;AIDS prevention;Blood;care seeking;Clinic;Clinical Trials Network;cohort;community advisory board;Congenital Syphilis;Data;Data Analyses;disorder prevention;Drug usage;Ectopic Pregnancy;Equipment;Ethnic Minority Women;Ethnic Origin;Ethnic Population;experience;follow-up;Goals;Gonorrhea;health care availability;health inequalities;Hepatitis C virus;high risk;HIV;HIV/HCV;housing instability;Human immunodeficiency virus test;improved;Incidence;Individual;Individual Differences;Inequity;Infant;Infection;infection burden;infection rate;infection risk;Injections;interest;Intervention;Lead;Legal;Link;male;Malignant Female Reproductive System Neoplasm;Marital Status;Measures;Mediating;Mediation;Medical;men;Mental Depression;Mental Health;Mission;Modification;Morbidity - disease rate;mortality;National Institute of Drug Abuse;novel;Outcome;Pathway interactions;Pelvic Inflammatory Disease;Persons;Pharmaceutical Preparations;Pharmacotherapy;Population;Pregnancy loss;pregnant;Prospective Studies;Prospective, cohort study;Public Health;Race;racial minority women;racial population;Reduce health disparities;reduced substance use;Research;Risk;Role;Sampling;Sex Behavior;sexual and reproductive health;sexual risk behavior;Sexually Transmitted Diseases;social;social factors;STI prevention;structural determinants;substance use;Syphilis;testing uptake;transmission process;treatment effect;United States;United States National Institutes of Health;Unsafe Sex;Variant;Virus Diseases;Woman;women versus men;women's diagnosis;Women's Group;Women's Health;Women's prevalence;women's reproductive health;Work

PROJECT_TITLE: Drug Treatment as Disease Prevention: Reducing Sexually Transmitted Infection Risk among Women Who Use Drugs

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Charcot-Marie-Tooth Disease;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Peripheral Neuropathy;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: Project Narrative These studies ask how defects in the gene IGHMBP2 result in two diseases SMA with Respiratory Distress (SMARD1) and Charcot Marie Tooth Type 2S (CMT2S). The results of these studies will provide important information towards understanding how events work normally and for the development of therapeutics to lessen or eliminate disease development and severity.

PI_NAMEs: LORSON, CHRISTIAN L. (contact);LORSON, MONIQUE A

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 3 year old;Address;Affinity;Amyotrophic Lateral Sclerosis;ATP phosphohydrolase;Binding;Binding Proteins;Biochemical;Biochemistry;Biogenesis;Biological Process;Cells;Charcot-Marie-Tooth Disease;Clinical;Collaborations;Complex;Data;Defect;design;Development;Disease;disease phenotype;Disease Progression;disease-causing mutation;Electrophysiology (science);Event;experimental study;falls;Family;Foundations;Genes;Genetic;Genetic Transcription;Goals;Hand;helicase;Heterozygote;Investigation;Laboratories;life span;Modeling;Molecular;Molecular Biology;Motor;motor neuron degeneration;Motor Neuron Disease;Motor Neurons;mouse model;Mus;muscle degeneration;mutant;Mutation;Nerve Degeneration;Neurons;novel;Nucleic Acid Binding;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Property;Protein Biosynthesis;protein protein interaction;Proteins;Reagent;Research Personnel;Respiratory physiology;Ribosomal RNA;Ribosomes;RNA;Role;rRNA Precursor;Severities;Severity of illness;Spinal Muscular Atrophy;Spinal Muscular Atrophy with Respiratory Distress Type I;success;Symptoms;targeted treatment;Therapeutic;therapeutic development;Therapeutic Studies;Translations;Treatment Efficacy;U3 small nucleolar RNA;Weight;Work

PROJECT_TITLE: Understanding the role of patient-derived Ighmbp2 mutations in neurodegeneration and pre-rRNA processing

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Infectious Diseases;Microbiome

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative/Relevance The follicle associated epithelium (FAE) of the Peyer’s patch is comprised of Microfold (M) cells that are critical for the surveillance and delivery of gut luminal content to underlying immune cells. However, the mechanisms responsible for regulating human M cell function remain to be determined. The current study will utilize human enteroids co-cultured with innate immune cells to advance our understanding of how gut microbes and immune cells specifically regulate human M cell function.

PI_NAMEs: ZACHOS, NICHOLAS CONSTANTINE (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: adaptive immune response;Affect;Antigen-Presenting Cells;Antigens;Apical;apical membrane;Area;Bacteria;Calcineurin;Cell Differentiation process;Cell Physiology;Cell Volumes;Cells;Cellular Morphology;Coculture Techniques;commensal microbes;Complex;coronin protein;Crohn's disease;Cytoskeletal Proteins;Data;Development;dietary;Disease;Distal;Endocytosis;Enteral;enteric infection;Environment;Epithelial Cells;epithelial stem cell;Epithelium;Glycoproteins;Gut associated lymphoid tissue;gut microbes;gut microbiome;Hematopoietic;Homeostasis;Human;Immune;Immune response;Immune signaling;Immune Tolerance;Immunoglobulins;Immunologic Surveillance;improved;Infection;Inflammation;Innate Immune Response;insight;intestinal epithelium;Intestines;Investigation;Knowledge;LGR5 gene;Lung;Lymphoid Follicle;M cell;Macrophage;Mediating;Mediation;Mediator;Microbe;microbial;microbiome;Modeling;monocyte;monolayer;Mucous Membrane;Mus;Nasal cavity;novel therapeutic intervention;oral vaccine;Organ;Organism;pathogen;pathogenic microbe;Pathogenicity;Patients;Peyer's Patches;Play;Process;Regulation;Research;response;Role;Sampling;Signal Pathway;Signal Transduction;Small Intestines;stem cells;Surface;synergism;Testing;trafficking;transcytosis;Update;uptake;vaccine delivery;Vaccines

PROJECT_TITLE: Human M Cells Require Coronin 1a

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Precision Medicine

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: NARRATIVE The proposed research is relevant to public health because it will lead to development of biomarkers that reflect granular neurobiological principles underlying ASD and related neurodevelopmental conditions. Among these individuals, understanding and addressing challenges related to atypical sensory processing is repeatedly noted as a common goal that would improve quality of life. In the long term, by developing objective brain-based measures of sensory processing (which has historically been a subjective phenomenon), this work has the potential to elevate research for a host of different diseases, alongside a wide variety of neurodevelopmental and sensory conditions.

PI_NAMEs: LEVIN, APRIL R. (contact)

PROGRAM_OFFICER_NAME: HARDY, KRISTINA KOREN

PROJECT_TERMS: 4 year old;Acoustic Stimulation;Address;Affect;age group;Anxiety;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;autistic children;Behavior;behavior observation;behavior prediction;Behavioral;behavioral phenotyping;behavioral response;Biological Markers;biomarker development;biotypes;Brain;brain based;Caregivers;Categories;Child;Child Development;Classification;clinical diagnosis;clinical diagnostics;Complement;Computer software;Data;Development;Diagnosis;diagnostic development;Disease;Electroencephalography;endophenotype;Functional disorder;functional outcomes;Goals;habituation;improved;Individual;individuals with autism spectrum disorder;innovation;Measurable;Measurement;Measures;Methods;neural;neural circuit;Neurobiology;Neurodevelopmental Disorder;neuromechanism;Neurons;Neurophysiology - biologic function;novel;outcome prediction;Output;personalized medicine;Pilot Projects;Public Health;Publishing;Quality of life;Research;response;Risk;Sampling;Sensory;sensory input;Sensory Process;sensory stimulus;Severities;Signal Transduction;social skills;Stimulus;Stratification;Subgroup;Symptoms;System;tactile stimulation;Testing;Time;time use;tool;Work

PROJECT_TITLE: Paradoxical Sensory Responses: A Clue Towards Understanding Biotypes in Autism Spectrum Disorder and Other Neurodevelopmental Disorders

STUDY_SECTION: DBD

STUDY_SECTION_NAME: Developmental Brain Disorders Study Section[DBD]