NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: The innate immune response is a critical first line of defense in our cells that exploits features unique to foreign molecules to accurately detect pathogens while avoiding unwanted self-activation. We propose studies that will define the molecular features of RNA molecules that drive activation of one important component of this cellular defense system. Fundamental studies like these are a critical platform for development of new and better therapeutic strategies based on a more complete understanding of our cell’s defense pathways, and the mechanisms by which pathogens are able to counteract them.

PI_NAMEs: CONN, GRAEME L (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: 2-5A Synthetase;2019-nCoV;Active Sites;Adhesions;Affect;Anti-viral Agents;Anti-viral Response;Automobile Driving;Award;Base Pairing;Binding;Binding Sites;Biochemical;Biological;Biological Assay;Biology;Biophysics;Cell Adhesion;Cell Physiology;Cell Proliferation;Cells;Complex;Consensus Sequence;Coupled;Cryoelectron Microscopy;Data;Dependence;Detection;Development;Distant;Double-Stranded RNA;Elements;Endoribonucleases;Enzyme Activation;Foundations;Human;Human Pathology;In Vitro;Individual;Innate Immune Response;Innate Immune System;innovation;insight;interdisciplinary collaboration;Length;Ligase;Link;Maintenance;Mediating;Messenger RNA;Modeling;Molecular;Molecular Mechanisms of Action;Molecular Profiling;multidisciplinary;novel;novel therapeutics;oligoadenylate;particle;pathogen;Pathogen detection;pathogenic virus;Pathway interactions;Pattern;Polymers;Positioning Attribute;Process;Productivity;Protein Biosynthesis;Protein Family;Proteins;Publishing;Regulation;Resistance;Resolution;response;Ribonucleases;RNA;RNA Sequences;Role;Second Messenger Systems;Structure;System;Testing;Therapeutic;tripolyphosphate;Untranslated Regions;Untranslated RNA;Viral;Viral Proteins;viral RNA;Virus;Virus Diseases

PROJECT_TITLE: dsRNA regulation of the cytosolic innate immune system

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE This research project will study a molecular link between cell homeostasis and innate immunity. This work is relevant to public health because it will illuminate fundamental mechanisms controlling immunity, thereby increasing our understanding of infectious disease, cancer, and autoimmune, neurodegenerative, and metabolic disorders.

PI_NAMEs: BACHOVCHIN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Acceleration;Affect;Amino Acid Sequence;Amino Acids;Area;Autoimmune Diseases;Biology;C-terminal;Cancer Etiology;Cell Death;Cells;Cellular Metabolic Process;Cellular Structures;Communicable Diseases;Complex;Cysteine;Data;Dipeptides;Dipeptidyl Peptidases;Disease;disulfide bond;Foundations;Future;Health;Homeostasis;Human;human disease;Immune response;Immunity;Inflammasome;Inflammatory;inhibitor;Innate Immune System;Knowledge;Laboratories;Length;Ligand Binding;Link;Lytic;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;Metabolic Diseases;Metabolic dysfunction;Mitochondria;Molecular;Monitor;multicatalytic endopeptidase complex;Multiprotein Complexes;N-terminal;Natural Immunity;Neurodegenerative Disorders;Oxidation-Reduction;Paper;pathogen;Pattern recognition receptor;Peptides;peptidomimetics;Play;Printing;Process;Proline;protein degradation;Protein Region;Proteins;Proteomics;Public Health;Reactive Oxygen Species;receptor binding;Reporting;Repression;Research;Research Project Grants;Serine;Signal Transduction;small molecule;Stress;T-Lymphocyte;Therapeutic;Work

PROJECT_TITLE: Characterizing the Mechanism of DPP8/9 Inhibitor-Induced Pyroptosis

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The studies we propose here should lead to the development of urgently needed vaccines that overcome the barriers for successful mobilization of CD8 T cell responses against clinically important intracellular pathogens such as HIV, Ebola, and Dengue viruses for which no vaccines are currently available. Dissecting the subcellular mechanisms that optimize microbial antigen cross-presentation during infection will inform the design of effective CD8 T cell vaccines.

PI_NAMEs: BLANDER, JULIE MAGARIAN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adjuvant;aluminum sulfate;Antibodies;Antigen Presentation;Antigen-Presenting Cells;Antigens;Bacteria;Binding;CD14 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell membrane;Cells;Cellular biology;Cellular Immunity;Clinical;clinically relevant;Cross Presentation;Cytoplasmic Tail;cytotoxic CD8 T cells;Dendritic Cells;Dengue Virus;design;Development;Diameter;Ebola virus;emerging pathogen;Endocytosis;Endosomes;Hepatitis A;Hepatitis B;HIV;Human Papilloma Virus Vaccine;Immune system;Immunity;Immunologic Memory;in vivo;Infection;Infection Control;Inflammatory Response;Influenza;Influenza A virus;ITAM;Licensing;Ligands;Liposomes;Major Histocompatibility Complex;Malaria;Mediating;Membrane;Memory;Meningococcal vaccine;MHC Class I Genes;Microbe;microbial;microorganism antigen;Mus;Mutate;nanoparticle;Nature;novel;Nucleoproteins;pandemic influenza;pandemic potential;particle;Particulate;pathogen;Pathway interactions;Peptides;Pertussis;Phagocytes;Phagocytosis;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;PIK3CG gene;Play;Pneumococcal vaccine;prevent;Process;Proteins;prototype;Publishing;QS21;receptor;Receptor Cell;Receptor Signaling;receptor-mediated signaling;Recombinant Proteins;recruit;Recycling;Regulation;Role;Route;Saponins;Signal Transduction;Site;Source;Subunit Vaccines;success;T cell response;T memory cell;Technology;Tissues;TLR2 gene;Toll-like receptors;trafficking;Tuberculosis;tumor;unpublished works;Vaccinated;Vaccination;Vaccine Antigen;vaccine formulation;Vaccines;Vesicle;Viral;Virus;Virus-like particle

PROJECT_TITLE: Toll-like receptor control of endocytic antigen cross-presentation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This project proposes to identify in vivo direct targets of androgen and WNT signaling during bladder carcinogenesis. Bladder cancer incidence is three times higher in men than in women but the underlying cause remains largely unknown. Using split DamID, this project will reveal crucial drivers of bladder carcinogenesis in males.

PI_NAMEs: MA, LIANG  (contact)

PROGRAM_OFFICER_NAME: LIU, ZHIHUI

PROJECT_TERMS: Address;Adenine;Adult;Androgen Receptor;Androgens;Bacterial DNA;beta catenin;Binding Proteins;Biological;Biological Assay;Bladder;Bladder Neoplasm;cancer initiation;Cancer Model;carcinogenesis;Carcinogens;Cell Proliferation;Chemicals;Chimeric Proteins;clinically relevant;Complex;Development;DNA;DNA-Binding Proteins;Embryo;Enzymes;EP300 gene;Epithelium;Gene Expression;Genes;Genetic Transcription;Genitalia;Genitourinary system;Gonadal Steroid Hormones;improved;in vivo;Incidence;Knowledge;Laboratories;Lower urinary tract;male;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammalian Cell;Maps;Masculine;men;Methylation;Modeling;Molecular;Organoids;Pathway interactions;Physiological;Play;Predisposition;protein complex;Proteins;Protocols documentation;Publications;Publishing;reconstitution;Recording of previous events;Reporting;Research;Rodent;Role;sex;Sex Bias;Sex Chromosomes;Sex Differences;Signal Transduction;Site-Specific DNA-Methyltransferase (Adenine-Specific);Small Interfering RNA;Smoking;Technology;Testing;tool;transcription factor;transcriptome sequencing;Transgenic Mice;Transgenic Model;Transgenic Organisms;Urothelium;WNT Signaling Pathway;Woman

PROJECT_TITLE: Androgen and Wnt signaling in bladder cancer

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_DEPT: NEUROSCIENCES

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The goal of this project is to investigate how non-human primates learn and represent information about serial order using inferential reasoning. We propose that serial order is learned using cognitive maps that support inference and thus allow organisms to adapt to novel circumstances. Health Relatedness: These experiments are relevant to Schizophrenia, Autism, Alzheimer’s disease, and other conditions whose patient populations have cognitive deficits, specifically those related to reasoning.

PI_NAMEs: FERRERA, VINCENT P (contact);TERRACE, HERBERT S.

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TITLE: Implicit serial learning

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics

ORG_CITY: DALLAS

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Changes in Meibomian gland (MG) lipid homeostasis have been linked to a range of ocular diseases, such as MG Dysfunction (MGD), Dry Eye syndrome (DES), chalazia, high triglycerides/low waxes syndrome (HTLW), and other pathologies. In our previous projects we focused our efforts on identification and characterization of genes and enzymes that are involved in the biosynthesis of meibum (which we termed meibogenesis), but we have not attempted to elucidate the mechanisms of its induction, regulation, and decline. In this new project, we will address these questions by conducting comprehensive characterization of meibogenesis in developing and aging MG of mice and humans, to find its triggers and key regulators, which could lead to new therapeutic strategies for curing various ocular pathologies, such as MGD, DES, HTLW, and others.

PI_NAMEs: BUTOVICH, IGOR A (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Ablation;Adult;Affect;Age;age effect;age group;Aging;aging biomarker;All-Trans-Retinol;Anabolism;Animal Model;aqueous;base;Biological Process;biophysical properties;Candidate Disease Gene;Cell Culture Techniques;Cell Differentiation process;Cells;Characteristics;Child;Childhood;Cholesterol Esters;Complex;Complex Mixtures;Confusion;Cornea;Data;Development;differential expression;Disease;Dry Eye Syndromes;Elderly;Embryo;Environment;Enzymes;Epidemiology;Epithelial Cells;Equilibrium;Esters;experimental study;Eye;Eye diseases;Film;Future;General Population;Genes;gland development;Goals;Growth;Health;histogenesis;Homeostasis;Human;human model;human old age (65+);human subject;Hydration status;Hypertriglyceridemia;Impairment;improved;in vivo;Infant;Knockout Mice;Knowledge;life span;Link;lipidomics;Lipids;Literature;Mammals;Maps;meibomian gland;meibomian gland dysfunction;Metabolic;Molecular;molecular marker;Morphogenesis;mouse model;Mus;Mutant Strains Mice;Mutation;Nature;novel therapeutic intervention;Ocular Pathology;Ocular Physiology;ocular surface;Organ;Organogenesis;Pathology;Pathway Analysis;Pathway interactions;Physiological;Physiology;Postembryonic;postnatal development;prenatal;Production;Property;Proteins;Proteomics;Quality of life;Reaction;Regulation;Reporting;Role;Signal Transduction;Surface;Syndrome;Tarsal plate;Testing;Thick;timeline;Tissues;transcriptome;transcriptomics;Vision;Waxes;Wild Type Mouse

PROJECT_TITLE: Meibogenesis in Health, Disease, and Aging

STUDY_SECTION: BDE

STUDY_SECTION_NAME: Biology and Development of the Eye Study Section[BDE]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Congenital Structural Anomalies;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Pediatric;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: COLUMBIA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative: Despite the success of combination antiretroviral therapy (cART), HIV-1-associated neurocognitive disorders (HAND) continue to afflict patients on cART, with a significant proportion exhibiting neurocognitive decline. A history of substance use disorder (SUD) may alter the progression and exacerbate HIV-1 neurocognitive decline. We will critically test how a history of SUD alters the neurocognitive and neuropathological sequelae of HIV-1 infection. The basis of our approach is to identify how infection of microglial cells leads to alterations in the fronto-striatal circuitry following SUD and HIV-1 infection, focusing on mechanisms of dendritic spine loss - a key neuropathology of neuroHIV in the current cART era.

PI_NAMEs: BOOZE, ROSEMARIE M (contact)

PROGRAM_OFFICER_NAME: MCCLURE-BEGLEY, TRISTAN DAVID

PROJECT_TERMS: Acceleration;Acute;Address;Affect;Animals;antiretroviral therapy;Architecture;Assessment tool;Behavior;biological sex;Brain;brain cell;Cell Culture Techniques;Choice Behavior;Chronic;Clinical;clinically significant;Cocaine;Cocaine Abuse;cocaine exposure;cocaine self-administration;comorbidity;Consequences of HIV;Cytoskeleton;Dendritic Spines;density;design;Dopamine;dopamine system;dopamine transporter;Drug abuse;Drug Addiction;Drug Exposure;Drug usage;Dysmorphology;Excision;Executive Dysfunction;executive function;Exhibits;Exposure to;F-Actin;Female;frontal lobe;Functional disorder;Future;Genes;Goals;Growth;hippocampal pyramidal neuron;HIV;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;improved;In Vitro;in vivo;in vivo evaluation;Individual;Infection;Knowledge;male;Measures;Medial;Mediating;Microglia;Microtubule-Associated Proteins;Modeling;Motivation;Natural regeneration;neuroAIDS;Neurocognitive;Neurocognitive Deficit;Neurologic;neuromechanism;Neurons;neuropathology;novel therapeutic intervention;Nucleus Accumbens;Outcome;Pathologic;Pathology;Pathway interactions;Patients;Pharmaceutical Preparations;Play;Prefrontal Cortex;programs;psychostimulant;Recording of previous events;Reporting;Resistance;Role;Scanning;Self Administration;sex;Signal Pathway;Specific qualifier value;Stimulant;stimulant abuse;Substance of Abuse;substance use;Substance Use Disorder;success;Synapses;synaptic function;Synaptic plasticity;System;targeted treatment;Techniques;Testing;therapeutic target;Up-Regulation;Ventral Tegmental Area;Vertebral column;Virus

PROJECT_TITLE: Microglial modulation of neurocircuits in HIV/cocaine comorbidity

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: The research outlined in this proposal will determine how circadian clocks control electrical coupling in the photoreceptor network. We will use several new mouse lines to investigate how electrical coupling in the photoreceptor network changes with the time of day and what effect this has on retinal input to the brain. Electrical coupling mediated by Cx36 gap junctions plays a critical role in many brain circuits and functions, thus we anticipate that the ability to control Cx36-mediated coupling may have useful clinical potential.

PI_NAMEs: RIBELAYGA, CHRISTOPHE P. (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Affect;Behavior;behavior influence;Brain;Chemical Synapse;circadian;circadian pacemaker;Circadian Rhythms;Clinical;Cone;congenic;Congenic Mice;connexin 36;Contrast Sensitivity;Coupled;Coupling;Darkness;Detection;Dopamine;Electrical Synapse;Electroretinography;Elements;Exhibits;ganglion cell;Gap Junctions;Impairment;Knock-in;Knock-out;Knowledge;Learning;Light;light intensity;Lighting;Measurement;Measures;Mediating;Melatonin;millisecond;mimetics;Motion;Mouse Strains;multi-electrode arrays;Mus;mutant;neural circuit;neural network;Neurons;Noise;Output;Pathway interactions;Periodicity;Photoreceptors;Play;Reporting;Research;Retina;Retinal Ganglion Cells;Rod;Role;Secondary to;Signal Transduction;Synaptic plasticity;System;Testing;Time;tool;transmission process;Variant;Vertebrate Photoreceptors;Visual;Visual Perception;Visual System;voltage;water maze;Work

PROJECT_TITLE: Plasticity and Function of the Rod/Cone Gap Junction

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


ADMINISTERING_IC: ES

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

ORG_CITY: NEW ORLEANS

ORG_NAME: DEEP SOUTH CENTER FOR ENVIRONMENTAL JUSTICE, INC.

ORG_STATE: LA

PHR: Project Narrative The HBCU and Communities Consortium Hazardous Waste Worker Training Program is uniquely designed to reach populations for training that, due to poverty and or racism, have been disenfranchised and excluded from opportunities existing within a society that has a unique history especially in the South that is teeming with the vestiges of racial inequality and social injustice in ways that continue to manifest in social and environmental determinants of health and well-being. The training program is informed by research and history on the intersection of race and place and the program also addresses basic inequities in resources for different communities across the country (rural vs urban) as well as differences in priorities for municipalities and city agencies, with training being first to be cut. Additionally, the Consortium is unique in its make-up in that it includes Historically Black Colleges and Universities (HBCUs) and Community Based Organizations (CBOs), that by design, serve the selected target populations.

PI_NAMEs: BULLARD, ROBERT D;WRIGHT, BEVERLY L (contact)

PROGRAM_OFFICER_NAME: BEARD, SHARON

PROJECT_TERMS: Address;Adult;Affect;African American;Area;Asian Americans;authority;Black race;Budgets;Businesses;career;career networking;Chemicals;Church;Cities;Climate;climate change;climate impact;Collaborations;college;Communities;community college;Community Health Aides;community organizations;Containment;Contractor;cost efficient;Country;County;County Government;Deep South;design;Disadvantaged;Disadvantaged minority;Disasters;Educational workshop;Emergency response;emergency service responder;Employee;Employment;Ensure;Environmental Health;environmental justice;Event;Excision;Exclusion;experience;Exposure to;Family;Fire - disasters;Foundations;Goals;Government;hazard;Hazardous Chemicals;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Hazardous Waste Sites;Health;health determinants;health disparity;health training;Historically Black Colleges and Universities;Hour;Human;Hurricane;improved;Inequity;Institution;Instruction;International;Latinx;Life;Link;Marketing;Mathematics;member;Methods;Minority;Modeling;Mosquito Control;Municipal Government;Municipalities;New York;occupational health/safety;Occupations;Oils;outreach;Participant;Personal Satisfaction;Police Forces;Pollution Prevention;Population;Poverty;prevent;professional atmosphere;Program Evaluation;programs;Property;Provider;Race;racial disparity;racism;Readiness;Reading;Recording of previous events;Recovery;recruit;Regulation;remediation;Reporting;Research;resilience;Resources;response;restoration;restraint;Risk;Rural;Safety;Services;Site;skills;social;Societies;Study Skills;System;Target Populations;Techniques;Technology;Texas;Training;Training and Education;Training Programs;Training Technics;trend;Underrepresented Minority;Underserved Population;United States Occupational Safety and Health Administration;Universities;volunteer;wasting;Work;worker safety

PROJECT_TITLE: The Historically Black Colleges/Universities and Communities Worker Health and Safety Training Program


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Rural Health;Social Determinants of Health

PI_NAMEs: WRIGHT, BEVERLY L (contact)

PROJECT_TERMS: Address;Adult;authority;Black race;Budgets;Businesses;career;career networking;Chemicals;Cities;Climate;climate change;climate impact;Collaborations;college;Communities;Community Health Aides;community organizations;Containment;cost efficient;County;County Government;Deep South;design;Disadvantaged;Disasters;Educational workshop;Emergency response;emergency service responder;Employee;Ensure;Environmental Health;environmental justice;Event;Excision;Exposure to;extreme weather;Faculty;Family;Fire - disasters;Foundations;Goals;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;health disparity;health training;Historically Black Colleges and Universities;Human;Hurricane;improved;Industrialization;International;Jordan;Location;Marketing;Minority;Modeling;Mosquito Control;Municipal Government;Municipalities;occupational health/safety;Occupations;Oils;outreach;Participant;people of color;Personal Satisfaction;Persons;Police Forces;Pollution Prevention;Population;prevent;professional atmosphere;Program Evaluation;programs;Provider;Public Policy;Readiness;Recovery;recruit;Regulation;Reporting;resilience;response;restraint;Risk;Safety;Schools;Services;Site;Technology;Texas;Training;Training and Education;Training Programs;Training Technics;trend;underserved community;Underserved Population;Unemployment;United States Occupational Safety and Health Administration;Universities;volunteer;wasting;Work;worker safety


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HANOVER

ORG_DEPT: CHEMISTRY

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative This proposal presents a strategy to elucidate the inhibition mechanisms of first-in-class therapeutics that target intrinsically disordered proteins, which represent an enormous pool of potential drug-targets largely considered “undruggable” by conventional structure-based drug design approaches. This work will increase our understanding of how to rationally design small molecule drugs to inhibit intrinsically disordered proteins and will provide new avenues to therapeutic interventions for currently untreatable diseases.

PI_NAMEs: ROBUSTELLI, PAUL  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: androgen independent prostate cancer;Androgen Receptor;Antineoplastic Agents;Binding;Biological;Biophysics;Cellular Assay;Clinical;Clinical Trials;Development;Disease;drug candidate;Drug Design;Drug Targeting;experimental study;Human;human disease;inhibitor;insight;Laboratories;Measurement;Mediating;Methods;Molecular;Molecular Conformation;N-terminal;NMR Spectroscopy;novel;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Physical condensation;Physiological;protein misfolding;Proteins;Proteome;rational design;Research;Role;simulation;small molecule;Structure;Therapeutic;Therapeutic Intervention;therapeutic target;three dimensional structure;Work

PROJECT_TITLE: Characterizing the binding mechanisms of castration-resistant prostate cancer therapeutics to the intrinsically disordered N-terminal domain of the androgen receptor

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PROJECT_TERMS: 18 year old;Academia;Academic achievement;Academic skills;Address;Adult;Affect;apprenticeship;Area;authority;Behavior;Black race;Budgets;Businesses;career;career preparation;Chemicals;Church;Cities;citizen science;Collaborations;Communities;Community Health Aides;community organizations;community partners;computer science;Computers;Containment;Contractor;Counseling;Country;County;curriculum development;Deep South;design;Disadvantaged;Disadvantaged minority;Disasters;Educational workshop;emergency service responder;Employee;Employment;environmental justice;Excision;Exclusion;Exposure to;Faith-based organization;Family;Fire - disasters;Goals;hazard;Hazardous Chemicals;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;health determinants;health disparity;Health education;health training;Historically Black Colleges and Universities;Hurricane;Industry;Inequity;Institution;Instruction;interest;International;Jordan;Life;Local Government;Location;Mathematics;member;Mentors;Methods;Minority;Modeling;Mosquito Control;Municipalities;neighborhood disadvantage;New York;occupational health/safety;Occupations;outreach;Participant;Personal Satisfaction;Police Forces;Pollution Prevention;Population;Poverty;Privatization;Program Evaluation;programs;Property;Provider;psychologic;Qualifying;Race;racial disparity;racism;Readiness;Reading;Recording of previous events;Recovery;recruit;remediation;Research;Resources;response;restoration;restraint;Risk;Rural;Safety;safety education;Schools;Science;Services;Site;skills;skills training;social;Societies;sound;Study Skills;Target Populations;Techniques;Technology;Texas;Training;Training and Education;Training Programs;Training Technics;Underrepresented Minority;underserved community;Underserved Population;United States Occupational Safety and Health Administration;Universities;volunteer;vulnerable community;Work


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: LOWELL

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MASSACHUSETTS LOWELL

ORG_STATE: MA

PHR: Project Narrative This is a proposal for a regional health and safety training program to be implemented by The New England Consortium-Civil Service Employees Association (TNEC-CSEA), a partnership between the University of Massachusetts Lowell (UML), four New England coalitions for occupational safety and health (COSH groups).

PI_NAMEs: TURCOTTE, DAVID  (contact)

PROJECT_TERMS: Adult;advocacy organizations;Advocate;Affect;Awareness;Businesses;care providers;chemical safety;climate change;climate disaster;Communicable Diseases;Communities;Connecticut;County;Creativeness;Day Care;disaster resilience;Disasters;Disease Outbreaks;Education;Educational Models;Emergency response;emergency service responder;Emergency Situation;Employee;Employment Opportunities;empowerment;Environmental Health;environmental justice;Equipment;Event;evidence base;experience;Exposure to;extreme weather;Floods;Government;Government Programs;Grant;hazardous materials disaster;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;health care service;Health education;health organization;Healthcare;Hour;Human Resources;Immigrant;Immigrant worker;Industrialization;Industry;Infrastructure;Injury;innovation;Knowledge;landfill;Latino;Lead;Leadership;Learning;Link;Maintenance;manufacture;Massachusetts;Measures;Mechanics;member;Movement;Municipalities;National Institute of Environmental Health Sciences;Natural Disasters;New England;New Hampshire;New York;Occupational;occupational health/safety;Occupations;operation;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Population;prevent;preventive intervention;Privatization;procedure safety;programs;Public Health;Public Sector;Readiness;remediation;repaired;Research;Research Personnel;response;Rhode Island;Risk;Safety;safety education;Sanitation;school district;Science;Services;skills;Spanish/English;Target Populations;Trainers Training;Training;Training and Education;Training Programs;Translating;Transportation;tribal organization;U-Series Cooperative Agreements;Underserved Population;Universities;weather-related disaster;Work;Workplace

PROJECT_TITLE: Hazardous Materials Worker Health and Safety Training (U45), Cooperative Agreement


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioids;Prevention;Social Determinants of Health

PROJECT_TERMS: Accidents;Adult;advocacy organizations;Affect;Area;Asbestos;authority;Awareness;Businesses;chemical safety;climate change;climate disaster;Collaborations;Collection;college;Communicable Diseases;Communication;Communities;community organizations;Computer Simulation;Confined Spaces;Connecticut;County;Creativeness;Decision Making;Disasters;Disease Outbreaks;drinking water;E-learning;Education;Educational Models;Emergency response;emergency service responder;Employee;Employment Opportunities;empowerment;environmental justice;Event;evidence base;experience;Exposure to;first responder;Government;Grant;hazard;Hazardous Substances;Hazardous Waste;Hazardous Waste Operations and Emergency Response;Health;Health Personnel;Healthcare;Hour;Immigrant worker;Industrialization;Injury;innovation;interest;Knowledge;Laws;Lead;Learning;Link;Low income;manufacture;Massachusetts;member;Minority;Movement;Municipalities;National Institute of Environmental Health Sciences;New England;New Hampshire;New York;Occupational;occupational health/safety;Occupations;Opioid;opioid misuse;opioid use;opioid use disorder;Participant;Polychlorinated Biphenyls;Populations at Risk;prevent;preventive intervention;programs;Public Health;Public Sector;Readiness;recruit;remediation;Research;response;Rhode Island;Risk;Safety;Science;Services;severe weather;simulation;Site;skills;Small Business Innovation Research Grant;Students;Substance Use Disorder;Superfund;Target Populations;tool;Toxin;Training;Training Programs;Training Support;Translating;Transportation;tribal organization;U-Series Cooperative Agreements;Underrepresented Populations;Underserved Population;Universities;Urban Community;urban underserved;Vulnerable Populations;Water;weather-related disaster;Work;Workplace


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative Primary open angle glaucoma (POAG) is one of the most common causes of blindness in the United States. Elevated intraocular pressure (IOP) is a leading risk factor for POAG and lowering pressure is the only effective treatment for this devastating disease. This proposal will investigate a gene variant in a protein called thrombospondin-1 to gain a better understanding of its role in IOP regulation in normal and glaucomatous eyes.

PI_NAMEs: KELLER, KATE E (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Affect;Age;Amino Acids;antagonist;Anterior;aqueous;Aqueous Humor;Binding;Binding Proteins;Biological Assay;Biological Markers;Blindness;Calcium Binding;Cell Physiology;cell type;Cells;Characteristics;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Confocal Microscopy;CRISPR correction;Data;design;Development;Disease;Drainage procedure;effective therapy;Electron Microscopy;enzyme activity;Enzymes;Extracellular Matrix;Extracellular Matrix Proteins;Eye;Family;Functional disorder;Gelatinase A;Genetic;genetic variant;Genotype;Glaucoma;Heparin Binding;Homeostasis;Human;In Situ;In Vitro;insight;Integrin Binding;Integrins;Knockout Mice;Ligation;Matrix Metalloproteinases;Measures;Mechanics;Modeling;Modification;Molecular;mRNA Expression;nerve damage;new therapeutic target;Normal Cell;normotensive;novel;Optic Disk;Optic Nerve;optic nerve disorder;overexpression;Pathway interactions;Patients;Peptides;Perfusion;Persons;Phagocytosis;Physiologic Intraocular Pressure;Play;Predisposition;pressure;prevent;Primary Open Angle Glaucoma;protein protein interaction;Proteins;Publications;Quantitative Reverse Transcriptase PCR;Recombinant Proteins;Regulation;Reporting;Resistance;response;Risk Factors;Role;Single Nucleotide Polymorphism;Stress;Stretching;Testing;TGFB1 gene;THBS1 gene;Therapeutic;Thrombospondin 1;Tissues;Trabecular meshwork structure;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;United States;Variant;Vision;Western Blotting

PROJECT_TITLE: Thrombospondin-1 in normal and glaucomatous trabecular meshwork

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

PROJECT_TERMS: Address;Adult;advocacy organizations;Affect;Area;Awareness;Behavioral;Businesses;care providers;chemical safety;Child Care;climate change;climate disaster;combat;Communicable Diseases;Communities;community organizations;Connecticut;County;Creativeness;Day Care;disabled;Disasters;Education;Educational Models;Elderly;Emergency response;emergency service responder;Emergency Situation;Employee;empowerment;environmental justice;Event;evidence base;experience;Exposure to;extreme weather;Fentanyl;Floods;Foundations;Government;Grant;hazard;Hazard Controls;hazardous materials disaster;Hazardous Substances;Health;Health Personnel;Healthcare;Heat Stress;heroin use;Hour;Human Resources;Immigrant;Immigrant worker;Industry;Infrastructure;Injury;innovation;Knowledge;Latino;Learning;Legal Status;Link;Maintenance;man-made disasters;manufacture;Massachusetts;Molds;Movement;Municipalities;National Institute of Environmental Health Sciences;Needles;New England;New Hampshire;New York;occupational health/safety;Occupations;Opioid;opioid epidemic;opioid misuse;opioid use disorder;Participant;peer;Population;prescription opioid addiction;prevent;preventive intervention;Private Sector;programs;Psyche structure;Public Health;Public Sector;Readiness;Recovery;remediation;resilience;Resources;response;Rhode Island;Risk;Risk Factors;Safety;Sanitation;Schools;Science;Services;severe weather;Site;skills;Spanish;Spanish/English;statistics;Stress;Target Populations;tool;Training;Training Programs;Translating;Transportation;tribal organization;U-Series Cooperative Agreements;Underserved Population;Universities;Work;Workplace;Youth


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Clinical Research;Genetics;Human Genome

ORG_CITY: SEATTLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Large-scale variant-level functional data can substantially reduce the clinical burden of variants of uncertain significance, but no infrastructure exists to capture and present this data to clinicians in a manner that can be incorporated into standard clinical variant interpretation workflows. We propose to leverage our leadership in both large-scale functional assay technology development and clinical genetics to address this critical challenge by building and testing the infrastructure and knowledgebase that will empower clinicians to integrate variant-level functional data into clinical practice.

PI_NAMEs: STARITA, LEA  (contact);STERGACHIS, ANDREW BEN

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: Acute;Address;Biological Assay;BRCA1 gene;Case/Control Studies;Classification;Clinical;clinical care;Clinical Data;clinical database;clinical decision-making;clinical encounter;clinical practice;clinically relevant;ClinVar;Code;Communities;dashboard;Data;data modeling;Data Set;data standards;Databases;Deposition;Development;Disease;Educational Curriculum;Educational workshop;empowerment;Equity;Exclusion;Frequencies;Genes;Genetic;genetic variant;genomic data;Genomic medicine;Genomics;Guidelines;health care disparity;human disease;Human Genetics;Human Genome;improved;Individual;Infrastructure;insight;interest;International;Knowledge;knowledgebase;Laboratories;Leadership;Link;Measurement;Medical;Medical Genetics;metadata standards;Modeling;multiplex assay;Notification;Pathogenicity;Patients;Population;Population Heterogeneity;Process;Provider;Quality Control;Recommendation;repository;Research;research clinical testing;Research Personnel;Resources;segregation;Single Nucleotide Polymorphism;Standardization;statistics;System;technology development;Testing;TP53 gene;Training;Untranslated RNA;Update;uptake;Variant;variant of unknown significance;Visualization

PROJECT_TITLE: Advancing the implementation of variant-level functional data into clinical databases and clinical practice


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: JACKSONVILLE

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE (APOE U19: OVERALL) The overarching theme of this U19 project is to understand the biology and pathobiology of apolipoprotein E whose gene represents the strongest genetic risk factor for Alzheimer’s disease and several other aging- related conditions. The U19 will take advantage of the strengths and existing synergy among its multi- disciplinary and multi-institutional investigators to elucidate how apolipoprotein E isoforms have profound effects on functional outcomes at the molecular, cellular, and systems levels, and how these pathways can be targeted for therapy. This U19 project will also engage the broader scientific community by sharing knowledge, resources, and data through a web portal and by promoting collaboration through an annual ApoE Symposium.

PI_NAMEs: GOATE, ALISON M;HOLTZMAN, DAVID M.;KANEKIYO, TAKAHISA  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: Acceleration;Address;Age;age related;Age-associated memory impairment;Aging;aging brain;aging related;aging related disease;Alleles;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid beta-Protein;Animals;Apolipoprotein E;Astrocytes;Automobile Driving;Autopsy;Biochemical;Biochemistry;Bioinformatics;Biological Markers;Biological Models;Biology;biomarker discovery;Biometry;biophysical properties;Biophysics;Blood Vessels;Brain;brain cell;Cell Nucleus;cell type;Cells;Collaborations;Collection;Communities;Data;data management;Data Set;design;Development;Disease;Disease Pathway;Ensure;Event;Fostering;functional outcomes;Genes;Genetic;genetic analysis;genetic risk factor;Genomics;Genotype;Goals;healthy aging;Human;human induced pluripotent stem cells;Impaired cognition;improved;in vivo;induced pluripotent stem cell;innovation;insight;Institution;Interruption;Knowledge;large datasets;Link;Lipid Binding;lipid metabolism;lipidomics;Lipids;Lipoproteins;Liquid substance;Mediating;metabolomics;Microdialysis;Microglia;Modeling;Molecular;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;neuropathology;Neurosciences;Organoids;Outcome;particle;Pathogenicity;Pathologic;Pathology;Pathway interactions;Physiological;Post-Translational Protein Processing;prevent;Prevention strategy;Property;protective allele;Protein Isoforms;Proteins;Proteomics;Reagent;Recommendation;Research;Research Personnel;Resource Sharing;Resources;Risk;Risk Factors;risk variant;single-cell RNA sequencing;structural biology;Structure;symposium;synergism;System;targeted treatment;tau Proteins;Testing;Therapeutic;therapeutic development;Time;treatment strategy;United States National Institutes of Health;Vascular Cognitive Impairment;web portal;Work

PROJECT_TITLE: Biology and pathobiology of apoE in aging and Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

PI_NAMEs: KANEKIYO, TAKAHISA  (contact)

PROJECT_TERMS: Accountability;Address;Administrative Personnel;Advisory Committees;Aging;aging related;Alzheimer's Disease;analytical method;Apolipoprotein E;Biochemical;Bioinformatics;Biological Models;Biology;Biometry;Clinic;Collaborations;Communities;Complex;Data;data access;data management;Data Set;data sharing;Dedications;Department chair;design;Ensure;Event;experience;Genotype;Goals;Impaired cognition;Individual;innovation;Institution;Interdisciplinary Study;Knowledge;Knowledge Portal;LDL-Receptor Related Protein 1;Lead;Leadership;medical schools;meetings;Nervous System Disorder;Neurology;Neurosciences;novel;Pathogenesis;Pathogenicity;Pathway interactions;Positioning Attribute;programs;Progress Reports;Property;protective effect;Protein Isoforms;Publications;Quality Control;Reagent;Recording of previous events;Reproducibility;Research;research in practice;Research Personnel;Resource Sharing;Resources;responsible research conduct;Risk;Role;sharing platform;Site;Structure;symposium;synergism;System;Therapeutic;United States National Institutes of Health;Universities;Washington;web portal;web site

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: NEUROSURGERY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Immunotherapy is an exciting new approach to solid tumors and active investigations are underway for glioblastoma (GBM). The role of immunotherapy in the context of the current standard of care is unknown and our project will study the effects of local and systemic chemotherapy on the immune system and the antitumor immune response. We will perform our study in the preclinical and clinical setting.

PI_NAMEs: LIM, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: Acceleration;Address;Adult;anti-CTLA4;anti-PD-1;anti-PD1 antibodies;anti-PD1 therapy;anti-tumor immune response;antigen detection;Antigen Presentation;Antigen-Presenting Cells;Antigenic Diversity;Antigens;Apoptosis;Automobile Driving;biomarker identification;Brain Neoplasms;cancer immunotherapy;cancer type;Carmustine;Cell Communication;Cell Migration Induction;Cervical lymph node group;checkpoint inhibition;chemokine;Chemoresistance;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;clinical practice;Clinical Trials;clinically relevant;Clone Cells;Conflict (Psychology);Data;Deep Cervical Lymph Node;Dendritic Cells;Dependence;detection assay;DNA;DNA Damage;efficacy testing;experimental study;Failure;Flow Cytometry;Foundations;gene repair;Gliadel;Glioblastoma;Glioma;Goals;immune checkpoint blockade;Immune Evasion;immune function;Immune response;Immune system;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;Infiltration;insight;Institution;Investigation;Knowledge;Laboratories;Location;Lymphopenia;Malignant neoplasm of brain;Malignant neoplasm of lung;Malignant Neoplasms;Measures;Mediating;Melanoma;MGMT gene;migration;Mismatch Repair;Modality;Modeling;mouse model;Mus;Mutation;Myelosuppression;neoantigens;neoplastic cell;Newly Diagnosed;Nivolumab;novel;novel strategies;Outcome;Patient Care;Patients;Peripheral;Phase II Clinical Trials;phase II trial;Phenotype;Population;Positioning Attribute;potential biomarker;pre-clinical;Pre-Clinical Model;preclinical study;predicting response;preservation;Prognosis;Radiation;Recurrence;Regimen;Renal Cell Carcinoma;Reporting;responders and non-responders;response;response biomarker;Role;Solid Neoplasm;Specimen;standard care;standard of care;synergism;T memory cell;T-Cell Receptor;T-Lymphocyte;TAP1 gene;temozolomide;Testing;Therapeutic;Transfection;Treatment Efficacy;Treatment Protocols;tumor;Tumor Antigens;Tumor Cell Necrosis;Tumor Immunity

PROJECT_TITLE: Generating a Systemic Immune Response Using Localized Delivery of Chemotherapy in Brain Tumors

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE The cells and tissues of the human body age at different rates depending on their precise anatomical location and environment. We currently do not have a full understanding of this “heterogeneity” and how it contributes to overall human aging or the enhanced risk of diseases with age. The proposed San Diego Nathan Shock Center will provide a robust infrastructure to facilitate and promote the systematic study of cell and tissue heterogeneity in human aging.

PI_NAMEs: SHADEL, GERALD  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Advocate;Age;Age related pathologies;Aging;aging biomarker;aging mechanism;aging process;Anatomy;Artificial Intelligence;Basic Science;Biological;biological age;Biological Aging;Biological Models;Biology of Aging;career development;cell age;Cell Aging;Cell Communication;Cell model;cell type;Cells;Chronology;Clinical;cohort;Collaborations;Communication;Communities;complex data;Computer Models;computerized tools;data integration;Data Set;Development;disorder risk;Ensure;Environment;Environmental Exposure;Epigenetic Process;epigenomics;Event;functional decline;Functional disorder;Gene Expression;Goals;Grant;hallmarks of aging;Head;healthspan;Heterogeneity;Human;human disease;human model;human tissue;imaging approach;Imaging Techniques;Imaging technology;Individual;Infrastructure;innovation;Institution;interest;Intervention;intervention effect;Investigation;Knowledge;Leadership;Life;life span;Location;Longevity;mathematical model;Measures;meetings;member;Mentors;Methods;Mission;Modality;model organism;Modeling;Molecular;multiple omics;new technology;news;novel;Organoids;outreach;Pathologic;Pathway interactions;personalized intervention;Persons;Phenotype;Physiological;Pliability;Politics;Process;Productivity;programs;Protocols documentation;Research;research and development;Research Personnel;Resolution;Resources;Risk Factors;Role;Sampling;Services;Shock;single cell analysis;System;Technology;Tissue Model;Tissues;Training;transcriptomics;virtual

PROJECT_TITLE: San Diego Nathan Shock Center


NIH_SPENDING_CATS: Aging

PI_NAMEs: SACCO, ALESSANDRA  (contact)

PROJECT_TERMS: Aging;aging mechanism;aging process;Area;Award;Biological;Biology of Aging;career;Career Choice;career development;Cell model;Cells;Communities;Dedications;Development;Educational workshop;Emerging Technologies;Ensure;Evaluation;Event;Faculty;Feedback;Funding;Goals;graduate school;Grant;Heterogeneity;Human;innovation;interest;International;investigator training;Knowledge;Leadership;Learning;Medical;meetings;member;Mentors;Modeling;Molecular;Motivation;new technology;Participant;Persons;Pilot Projects;Play;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;practical application;pro-aging;programs;Qualifying;Reagent;Recording of previous events;Research;research and development;Research Personnel;Research Project Grants;Research Project Summaries;Resources;Role;Running;Science;Scientist;Services;Shock;skills;Speed;Students;Study Section;symposium;Techniques;Training;Travel;United States National Institutes of Health;Visit;Writing


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Immune responses protect us from infections but on the other hand can be destructive, leading to autoimmune diseases such as type I diabetes or rheumatoid arthritis or allergic responses such as asthma. Although, during the last 50 years, a tremendous amount has been learned about the immune response still much remains to be discovered. Thus, the goal of this Grant is to train predoctoral and postdoctoral fellows in further research on the basic mechanisms of the immune response, and application of such training to translational research.

PI_NAMEs: LENZ, LAUREL L;TORRES, RAUL MARTIN (contact)

PROJECT_TERMS: Immunology;Training Programs

PROJECT_TITLE: Training Program in Immunology

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


PI_NAMEs: BOWMAN, GREGORY  (contact)

PROJECT_TERMS: Adopted;Aging;aging related;Agreement;Alleles;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein;Apolipoprotein E;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;barrier to testing;Biochemical;Biochemistry;Biology;Blood Vessels;Brain;Cell Culture Techniques;cell type;Cells;Characteristics;clinical predictors;Collaborations;Complex;Computer Models;Conditioned Culture Media;Cryoelectron Microscopy;Data;design;Development;Disease;Event;experimental study;Foundations;Future;Genes;genetic risk factor;Genotype;Goals;Heterogeneity;Human;induced pluripotent stem cell;insight;Lipid Binding;Lipids;Lipoproteins;Methods;Microglia;Modeling;Molecular Conformation;molecular dynamics;monomer;Mus;particle;Pathogenicity;Pattern;Plasma;Post-Translational Protein Processing;predictive signature;Property;Protein Isoforms;Proteins;Protocols documentation;rare variant;Resources;Sampling;Service delivery model;single molecule;Source;Structural Models;Structure;System;Techniques;Testing;Therapeutic;Tissue Sample;Variant;web portal

PROJECT_TITLE: Biochemistry and Structural Modeling Core


PROJECT_TERMS: Aging;aging mechanism;aging process;Biology of Aging;career development;Cell model;Collaborations;Collection;Communication;Communities;Data;data dissemination;Development;Educational workshop;Ensure;Equilibrium;Event;Faculty;Fostering;Funding;Goals;Grant;Heterogeneity;Human;improved;Institution;interest;lectures;Logistics;Measures;Mentorship;Modeling;Monitor;new technology;operation;outreach;Phase;podcast;Program Development;Program Effectiveness;programs;Quality Control;Recommendation;Research;Research Activity;research and development;Research Personnel;Research Project Grants;Resources;Running;senior faculty;Services;Shock;success;symposium;Teacher Professional Development;Time;Training;Training Support;uptake;web site;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Depression;Health Services;Major Depressive Disorder;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Serious Mental Illness

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Project Narrative Electroconvulsive therapy (ECT) may be an effective treatment modality for severe neuropsychiatric symptoms (NPS) of Alzheimer’s disease and related dementias (ADRD). Using a nationwide, longitudinal cohort design, this study aims to examine associations of ECT with NPS and other key clinical outcomes among adults with ADRD in nursing homes. Findings will inform more effective clinical guidance on ECT use in nursing homes.

PI_NAMEs: RHEE, TAEHO GREGORY (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Address;Adult;Advisory Committees;Aggressive behavior;aging related disease;Agitation;Alzheimer's disease related dementia;American Psychiatric Association;anti-depressive agents;Antipsychotic Agents;Behavior Therapy;Bipolar Disorder;brain cell;care providers;caregiver education;Caring;Case Series;Certification;Cessation of life;Clinical;Clinical assessments;Clinical Trials;Cohort Studies;Data;Data Analyses;Data Set;Death Rate;Dementia;Depressed mood;depressed patient;design;Development;Discipline of Nursing;effective therapy;Effectiveness;Elderly;Electroconvulsive Therapy;environmental adaptation;Epidemiology;Fire - disasters;follow-up;frailty;functional disability;functional outcomes;Future;General Anesthesia;Guidelines;Health;Health Services Research;human old age (65+);improved;Incidence;indexing;Individual;innovation;insight;Intervention;Knowledge;Life;Link;Long-Term Care;longitudinal analysis;Longitudinal cohort;Longitudinal Studies;Maintenance;Medicaid;Medicare;Medicare claim;Mental Depression;Mental disorders;Methods;mixed dementia;Modality;Modeling;Morbidity - disease rate;mortality;mortality risk;multiple data sources;Neurodegenerative Disorders;neuropsychiatric symptom;Nursing Homes;Observational Study;older adult;older patient;Outcome;Patient Preferences;Patterns of Care;person centered;pharmacologic;Population;population based;Prevalence;Provider;psychotic depression;Public Health;Quality of Care;Quality of life;Randomized, Controlled Trials;Recommendation;Reporting;Research;Resources;response;Risk;Safety;Scalp structure;Schizoaffective Disorders;Seizures;Skilled Nursing Facilities;sociodemographics;Stimulus;Surveys;Syndrome;Techniques;Therapeutic;Time;treatment response;treatment-resistant depression;United States Centers for Medicare and Medicaid Services

PROJECT_TITLE: Epidemiology and Clinical Outcomes of Electroconvulsive Therapy Use in Nursing Home Residents with Dementia

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Aging;Clinical Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GAGE, FRED H (contact)

PROJECT_TERMS: 3-Dimensional;Adult;Age;age related;aged;Aging;aging process;Animal Model;Back;biobank;Bioenergetics;Biological;biological age;Biological Aging;biological research;Biology of Aging;Biometry;Blood;Body Composition;Cell Aging;Cell Communication;Cell Culture Techniques;Cell Line;Cell model;Cell Physiology;cell repository;cell type;Cells;Characteristics;Chronology;Clinical;cohort;Communities;complex data;Data;Data Set;data streams;Dermal;design;Educational workshop;Embryo;empowerment;Epigenetic Process;Exhibits;experimental study;Fibroblasts;Gene Expression Profile;Genetic Models;Goals;hallmarks of aging;Heart;Heterogeneity;Human;human induced pluripotent stem cells;human model;human subject;human tissue;Hybrid Cells;Hybrids;Image;Imaging technology;In Vitro;Individual;induced pluripotent stem cell;insight;Kidney;Knowledge;lectures;Liver;machine learning algorithm;Measures;Mitochondria;model organism;Modeling;Molecular;Molecular Profiling;multiple omics;novel;novel strategies;open source;Organ;Organoids;Pancreas;Participant;peripheral blood;Phenotype;phenotypic data;Physiological;Plasmids;Process;Protocols documentation;Punch Biopsy;Reagent;recruit;Rejuvenation;repository;Research;research and development;Resource Sharing;Resources;Role;Sampling;Series;Shock;Skin;Smooth Muscle;stem cells;Structure;System;technology development;Tissue Model;Tissues;Training;transgene expression;uptake;Work

PROJECT_TITLE: Core 1: Human Cell Models of Aging Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Liver Disease and Cirrhosis;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Disease

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

ORG_STATE: PA

PHR: In our original project, we established that portal vein pressures can be quantified noninvasively in humans using an innovative ultrasound based technology (i.e., SHAPE) and that this method can be successfully implemented using modified hardware across multiple sites. Hence, this renewal study bring together scientists and clinicians from Thomas Jefferson University, University of Pennsylvania and University of Bern with a premier manufacturer of ultrasound scanners (GE) in order to further develop SHAPE for the noninvasive evaluation of portal hypertension and to establish the clinical utility of SHAPE for the management of portal hypertension.

PI_NAMEs: FORSBERG, FLEMMING  (contact)

PROGRAM_OFFICER_NAME: SHERKER, AVERELL H

PROJECT_TERMS: Academia;accurate diagnosis;Adrenergic beta-Antagonists;Adult;Algorithms;Ascites;Blood Platelets;Catheters;chronic liver disease;Cirrhosis;Clinical;Clinical Trials;clinically significant;Compensation;Confidence Intervals;contrast enhanced;Contrast Media;cost;data acquisition;Death Rate;Development;Diagnosis;diagnostic accuracy;Early Diagnosis;elastography;Encephalopathies;Esophagus;Evaluation;Event;first-in-human;Grant;Healthcare;Hemorrhage;Hepatic;hepatic vein;Human;improved;Incidence;indexing;Industry;innovation;Liver;liver biopsy;Liver diseases;Logic;Manufacturer;Measurement;Methods;Monitor;Morbidity - disease rate;mortality;mortality risk;Multicenter Trials;National Institute of Diabetes and Digestive and Kidney Diseases;novel;Outcome;Patient Care;Patient-Focused Outcomes;Patients;Pennsylvania;Physicians;Pilot Projects;Portal Hypertension;Portal Pressure;Portal vein structure;Positioning Attribute;pressure;Primary carcinoma of the liver cells;Reproducibility;Research Personnel;response;Risk;Schedule;Scientist;screening;Site;Specificity;Symptoms;System;Techniques;Technology;Therapeutic Intervention;Transjugular intrahepatic portosystemic shunt procedure;Transplantation;Treatment Efficacy;treatment response;Triage;ultrasound;Universities;University Hospitals;Varicosity;Venous Pressure level

PROJECT_TITLE: Noninvasive Subharmonic Aided Pressure Estimation of Portal Hypertension

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Patient Safety;Precision Medicine;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: New tools in Genomic Medicine – polygenic risk scores, platforms to capture family history, and advanced electronic phenotyping – offer the prospect of early identification of people at especially high risk of common diseases. The eMERGEgram network is being formed to address this opportunity and in our application to join this initiative, we outline methods to allow the network to develop genomic risk assessments using these new tools; a plan to engage, recruit, and retain 2,500 subjects to receive these assessments; and methods to study outcomes in those designated high risk and those designated average risk. By enhancing our understanding of new methods to create and deliver genomic risk assessment, this project will enable prevention and early treatment of people at high risk for common diseases.

PI_NAMEs: RODEN, DAN M (contact);VELEZ EDWARDS, DIGNA R;WEI, WEI-QI

PROGRAM_OFFICER_NAME: ROWLEY, ROBB KENNETH

PROJECT_TERMS: Academic Medical Centers;Address;analytical method;Assessment tool;biobank;Bioethics;Biological Markers;Biomedical Research;care outcomes;Caring;Chronic Kidney Failure;Clinical;clinical decision support;Clinical Medicine;clinical phenotype;cohort;Colorectal Cancer;community engagement;Computerized Medical Record;Coronary Arteriosclerosis;Coupled;Data;Data Analytics;Data Set;Detection;Development;Discipline;Disease;Disease Progression;Disease susceptibility;disorder risk;DNA;Early Diagnosis;Early identification;Early treatment;Electronic Health Record;Electronic Medical Records and Genomics Network;Electronics;experience;Family;Family health status;Focus Groups;Future;genetic pedigree;genetic variant;Genome;genome wide association study;Genomic medicine;Genomics;Goals;Growth;Health;health care service utilization;Health Personnel;Healthcare;Heritability;high risk;Human;human old age (65+);improved;Individual;Informatics;Information Sciences;innovation;Intervention;Knowledge;large datasets;Learning;Link;Maps;meetings;Methods;Modeling;Modernization;National Center for Advancing Translational Sciences;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome Study;Participant;Pathogenicity;patient engagement;Patients;personalized approach;personalized care;Persons;Pharmaceutical Preparations;Pharmacogenomics;phenome;Phenotype;Physiological;polygenic risk score;Population;precision medicine;Predisposition;Prevention;Prevention approach;Productivity;programs;Provider;Recording of previous events;Records;recruit;Research;Resources;response;Risk;Risk Assessment;Risk Management;Sampling;Science;Site;Strategic vision;Subgroup;Testing;tool;trait;treatment response;Underrepresented Populations;United States National Institutes of Health;uptake;Uterine Fibroids;Validation;Variant

PROJECT_TITLE: Vanderbilt Genome-Electronic Records (VGER) Project


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Genetics;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PI_NAMEs: DICKSON, DENNIS WILLIAM (contact)

PROJECT_TERMS: Address;Age;age related;Aging;aging related;alpha synuclein;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;Animal Model;Animals;Apolipoprotein E;apolipoprotein E-4;Astrocytes;Autopsy;Biochemical;Bioinformatics;Biological Assay;Biology;Biometry;biophysical analysis;biophysical properties;Blood Vessels;Brain;brain control;Brain region;brain tissue;Cell model;cell type;Cells;Cerebral Amyloid Angiopathy;cerebrovascular;Cerebrovascular Disorders;Clinic;cohort;Collaborations;Collection;Communities;comorbidity;Confocal Microscopy;cytokine;Data;data management;density;Deposition;digital;digital pathology;Disease;Enzyme-Linked Immunosorbent Assay;Florida;Freezing;gene product;Genetic;genetic association;genomic locus;Genotype;glial activation;Goals;Histologic;Human;human model;Immunoassay;Immunohistochemistry;Individual;Inflammatory;innovation;Knowledge;Lewy Bodies;Lewy Body Disease;Link;Lipoproteins;Measurement;Measures;Methods;Microglia;multi-ethnic;multiple omics;Nerve Degeneration;neuroinflammation;Neurons;neuropathology;normal aging;novel;Outcome;particle;Pathologic;Pathology;Pathway interactions;Phenotype;Principal Investigator;Process;Protein Isoforms;protein TDP-43;Proteomics;Research;Research Personnel;Resources;response;Risk;Role;Sampling;Senile Plaques;Services;Severities;sex;Site;Source;Standardization;Synapses;tau Proteins;Tauopathies;Testing;Tissues;tool;transcriptomics;United States;Universities;Validation;Washington;web portal;Work

PROJECT_TITLE: Neuropathology Core


NIH_SPENDING_CATS: Aging;Bioengineering;Genetics;Human Genome;Machine Learning and Artificial Intelligence

PI_NAMEs: METALLO, CHRISTIAN MICHAEL (contact)

PROJECT_TERMS: Address;Age;age related;age related changes;aged;Aging;aging process;Algorithms;Artificial Intelligence;Biology of Aging;Cell Aging;Cell model;Cell Physiology;cell type;Cells;Collaborations;data acquisition;Disease;Ensure;Epigenetic Process;experience;Experimental Designs;functional decline;Functional disorder;Generations;Genome;Goals;Heterogeneity;high resolution imaging;Human;image processing;imaging modality;imaging system;Impairment;Individual;innovation;instrumentation;Investigation;Knowledge;Leadership;Machine Learning;Mass Spectrum Analysis;Measures;metabolomics;Methods;Modeling;Molecular;Mosaicism;multimodality;multiple omics;new technology;novel;Organ;Organelles;Organoids;Pathology;Process;protein function;Proteomics;Records;Research;Research Personnel;Research Project Grants;Research Support;Resolution;Resources;Role;Running;sequencing platform;Services;Shock;single cell sequencing;Site;System;Techniques;Technology;temporal measurement;Tissues;Training;transcriptome sequencing;transcriptomics;virtual;Work

PROJECT_TITLE: Core 2: Heterogeneity of Aging


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Conditions Affecting the Embryonic and Fetal Periods;Heart Disease;Pediatric;Pregnancy;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: NARRATIVE While anti-SSA/Ro-associated fetal complete (i.e., 3°) atrioventricular block (AVB), identified in the 2nd trimester in an otherwise normally developing heart, is fatal in a fifth of cases and for those who survive requires lifelong pacing, reversal of incomplete block is possible but challenging to identify given only once weekly echocardiographic surveillance. This study comprises three steps: 1) screening anti-Ro positive mothers for high-titer antibodies which are thought to confer greater risk of fetal AVB; 2) teaching mothers with high titer anti- Ro to monitor the fetal heart rate and rhythm at home and arrange immediate feedback on perceived abnormalities; 3) treating fetuses whose mothers detect abnormal monitoring confirmed to be incomplete AVB by echocardiogram. The purpose of our study is to find out whether the level of anti-Ro/SSA can predict fetuses at greatest risk, if mothers can themselves identify reversible fetal cardiac injury by home monitoring, whether expeditious treatment of fetal incomplete AVB can restore normal rhythm, and finally if weekly echocardiographic testing is necessary to surveil for AVB.

PI_NAMEs: BUYON, JILL P (contact);CUNEO, BETTINA FRANCESCA

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: Address;Agreement;Anti-Inflammatory Agents;Antibody titer measurement;arm;Atrioventricular Block;Autoantibodies;Biological Process;Birth;Bradycardia;cardiac pacing;Clinical;Colorado;congenital anomaly;Data;Detection;Dexamethasone;Disease;Early treatment;Echocardiography;Educational process of instructing;effusion;Electrocardiogram;empowerment;Endocardial Fibroelastosis;Ensure;Equipoise;Event;evidence base;Extranodal;Feedback;fetal;Fetal Heart Rate;Fetal Monitoring;Fetus;Fibrosis;Frequencies;Guidelines;Health Benefit;Healthcare;Heart;Heart Diseases;Heart Injuries;heart rhythm;Home;Hour;IgG Receptors;Incidence;Inflammation;Inflammatory;interdisciplinary collaboration;Intravenous Immunoglobulins;Lifelong disability;Mediating;medical schools;Medicine;millisecond;Monitor;Morbidity - disease rate;mortality;Mothers;Multicenter Trials;Myocardial dysfunction;National Institute of Child Health and Human Development;Natural History;network models;novel;Outcome;Participant;Pathogenesis;Perinatal mortality demographics;Phase;Placebos;Placenta;Pregnancy;prenatal;prenatal testing;prevent;primary outcome;programs;prospective;Public Health;recruit;Registries;Reporting;Research;Research Personnel;rheumatologist;Risk;Sample Size;screening;Second Pregnancy Trimester;side effect;Site;standard of care;support network;Survivors;System;Techniques;Testing;time interval;Universities;Woman

PROJECT_TITLE: Surveillance and Treatment to Prevent Fetal Atrioventricular Block Likely to Occur Quickly (STOP BLOQ)

STUDY_SECTION: NRCS

STUDY_SECTION_NAME: Nursing and Related Clinical Sciences Study Section[NRCS]


NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD)

PI_NAMEs: SHARPEE, TATYANA O. (contact)

PROJECT_TERMS: Age;Aging;aging related;Algorithms;Biological Process;Biology of Aging;Computer Models;Computer software;Data;Data Analyses;data infrastructure;data integration;Data Set;Disparate;Generations;Genes;Heterogeneity;high throughput screening;Image;interactive tool;Maps;metabolomics;Mission;Modeling;novel;Pathway interactions;Process;Proteomics;Research;Research Personnel;Resources;Role;Shock;single cell sequencing;Study models;Techniques;Testing;theories;tool;Translating;web portal;Work

PROJECT_TITLE: Core 3: Integrative Models of Aging Core


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Resilience is a key predictor of successful aging and also acts as a buffer to disaster exposure; however, successfully aging in areas that are prone to disasters is an emerging public health challenge, especially for community-dwelling older adults who lack the resilience needed to bounce back from these disruptive events. The goal of this project is to test a conceptual model that estimates how individual disaster resilience mediates the relationship between disaster exposure and successful aging, and use qualitative data to inform the design and piloting of a tablet-based intergenerational intervention to increase the disaster resilience of older adults. With a growing number of older adults aging in areas prone to hurricanes, floods, wildfires and heatwaves, increasing disaster resilience will provide community-dwelling older adults with the resources they need to successfully age-in-place, despite mounting environmental risk.

PI_NAMEs: MERDJANOFF, ALEXIS  (contact)

PROGRAM_OFFICER_NAME: NGUYEN, EMERALD THAI HAN

PROJECT_TERMS: acceptability and feasibility;Active Learning;Acute;Acute Disease;Address;Affect;Age;age group;Aging;aging in place;Area;Award;Back;Biometry;Buffers;Cessation of life;Chronic;Climate;Cognitive;Collection;Communities;comorbidity;County;Data;Data Analyses;Dedications;design;Desire for food;disaster resilience;Disasters;emotional distress;Enrollment;Environment;Environmental Risk Factor;Equation;Event;experience;Exposure to;feasibility testing;Floods;Focus Groups;Frequencies;Future;Gerontology;Goals;Health;Heat Waves;Hurricane;Individual;informant;intergenerational;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Longitudinal cohort study;Measurement;Measures;Mediating;Mediator;Mental Health;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;multidisciplinary;New Jersey;older adult;Pathway interactions;Personal Satisfaction;Phase;physical conditioning;Population;primary outcome;Procedures;Process;Program Acceptability;promote resilience;Public Health;Qualitative Methods;Readiness;Recovery;Research;Research Methodology;Research Personnel;resilience;resilience factor;Resources;response;Risk;Sampling;Science;Scientist;sea level rise;secondary outcome;Self Efficacy;Services;Severities;skills;social;social cohesion;Social Network;sociodemographics;Structure;Surveys;Tablets;Testing;theories;therapy design;Time;Training;Trauma;virtual platform;Wildfire;willingness;young adult

PROJECT_TITLE: Aging in Precarious Place: Building Resilience Among Older Adults Living in Environmentally Vulnerable Areas

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

ORG_CITY: WASHINGTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative  Cancer is a leading cause of death worldwide, and lymphoma is one of the most common form of blood cancers in the world. An understanding of HDAC11's role in regulating anti-cancer immunity will pave the way for developing potential new strategies to treat lymphoma patients. The proposed research is relevant to the NCI's mission to develop fundamental strategies and acquire knowledge that will improve healthcare and alleviate human suffering from cancer.

PI_NAMEs: LI, RONG ;LIN, HENING ;SETO, EDWARD  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: Acceleration;acyl group;Acylation;anti-cancer;anti-tumor immune response;Antigen-Presenting Cells;Antitumor Response;B lymphoid malignancy;Cancer Model;cancer therapy;Cause of Death;cdc42 GTP-Binding Protein;Cell Cycle;Cell Line;cell motility;Cell Physiology;Cell Polarity;Cells;Chemicals;Collaborations;Complex;cytokine;Data;Deacetylase;Deacetylation;Development;Disease;Enzyme Inhibitor Drugs;Enzymes;Excision;Family;fatty acylation;Functional disorder;Genetic Models;Glycine Hydroxymethyltransferase;Goals;Growth;HDAC11 gene;Healthcare;Hematologic Neoplasms;Hematopoietic Neoplasms;Histone Deacetylase;Histone Deacetylase Inhibitor;Human;IFNAR1 gene;Immune;immune function;Immune response;Immune signaling;Immune system;Immunity;immunoregulation;Immunotherapy;improved;In Vitro;in vivo;Individual;Infiltration;Inflammatory;inhibitor;insight;Interferon Type I;Interferons;Interleukin-10;isopeptidase;Knock-out;Knockout Mice;Knowledge acquisition;Laboratories;lymph nodes;Lymphoid Tissue;Lymphoma;Lymphoma cell;Lysine;Malignant Neoplasms;Mantle Cell Lymphoma;Mediating;Mediator;migration;Mission;Modeling;Molecular;Monomeric GTP-Binding Proteins;mouse model;multidisciplinary;Mus;neutrophil;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel drug class;novel therapeutics;Patients;Phagocytes;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacotherapy;Physiological;Play;Positioning Attribute;Predisposition;Process;Production;programs;Proliferating;Property;protein function;Proteins;Refractory;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;rho;Role;Signal Transduction;Site;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;tool;Transplantation;treatment strategy;tumor;tumor behavior;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;tumorigenesis;tumorigenic;United States;Universities;Washington;Wild Type Mouse;Work

PROJECT_TITLE: Regulation of anti-tumor immunity by HDAC11

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: abeta deposition;Acceleration;Age-associated memory impairment;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid beta-42;Animals;Apolipoprotein E;Autopsy;Biochemical;Biochemistry;Bioinformatics;Biological;Biological Assay;Biological Markers;Biological Specimen Banks;Biology;biomarker identification;Biometry;Blood Vessels;Brain;Brain Neoplasms;cell type;Cerebrospinal Fluid;Classification;Clinic;Clinical;clinical predictors;cognitive performance;cohort;Collaborations;Communities;Data;data management;Data Set;Dementia;Dependence;Deposition;design;Diagnosis;Disease;disease classification;Disease Progression;E protein;Early Diagnosis;Elderly;fluorodeoxyglucose positron emission tomography;Genotype;glial activation;Goals;Human;human induced pluripotent stem cells;human old age (65+);Individual;induced pluripotent stem cell;Inflammation;Infrastructure;innovation;Institution;Link;lipidomics;Liquid substance;Longitudinal cohort;Magnetic Resonance Imaging;Measurement;Measures;medical schools;Modeling;Monitor;mouse model;multidisciplinary;multiple omics;Mus;Nerve Degeneration;neuroimaging;neuropathology;novel marker;Onset of illness;particle;Pathogenicity;Pathologic;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Phase;Phenotype;Plasma;Positron-Emission Tomography;Post-Translational Protein Processing;Prevention;Process;programs;Property;Protein Isoforms;Proteomics;public database;Recording of previous events;Research;Risk;Sampling;specific biomarkers;Structural Models;Structure;Subjects Selections;Symptoms;Synapses;synergism;System;targeted biomarker;tau Proteins;tau-1;Time;Translational Research;Traumatic Brain Injury;United States National Institutes of Health;Universities;Validation;Visit;Washington

PROJECT_TITLE: Biomarker Core


ORG_NAME: INTERNATIONAL ASSOCIATION FIRE FIGHTERS

PHR: The International Association of Fire Fighters (IAFF) has been a partner with the National Institute of Environmental Health Sciences (NIEHS) Worker Training Program (WTP) since 1992, delivering over 1,630 classes and training more than 33,542 workers likely to respond to hazardous materials incidents, in an effort to prevent work related harm and improve worker health and safety. In addition to delivering highly technical training for HazMat incident response (e.g., Confined Space Rescue and Operations, HazMat Technician), the IAFF remains committed to delivering holistic training to address all aspects of worker safety including emerging topics such as occupational cancer risks, opiate and substance abuse disorders, behavioral health awareness, suicide prevention, and improving individual/community resiliency. The IAFF is committed to addressing these issues, by: continuing and improving the training and education of all potential responders (public, private, volunteer, community partners) who may be impacted by HazMat emergencies; utilizing innovative technologies for class delivery; and conducting ongoing quality control and program evaluation.

PI_NAMEs: BURGESS, JAMES ;SMITH, JOSHUA  (contact)

PROJECT_TERMS: Accreditation;Address;Aging;Awareness;behavioral health;Benchmarking;built environment;cancer risk;chemical responder;Chemicals;Collaborations;Communities;community partners;Complex;Confined Spaces;Consensus;Course Content;Data;Databases;Dedications;Development;Disasters;Disease;E-learning;Education;Educational Curriculum;Educational Status;Effectiveness;Electronics;Emergency response;emergency service responder;Emergency Situation;Ensure;Evaluation;evidence base;Exposure to;Face;Fire - disasters;fire fighter;first responder;Funding;Goals;Grant;hazardous materials disaster;hazardous materials worker;Hazardous Substances;Health;Health protection;health training;Improve Access;improved;Individual;Industrialization;Infrastructure;innovation;innovative technologies;Instruction;instructor;International;Learning;Libraries;manufacturing process;Measures;medical specialties;Methodology;Modeling;National Institute of Environmental Health Sciences;new technology;Occupational Malignant Neoplasm;Occupations;operation;opioid abuse;outreach;peer support;Performance;Personal Satisfaction;Persons;Pike fish;Plants;Population;Population Growth;Post-Traumatic Stress Disorders;prevent;Prevention;Privatization;Program Evaluation;programs;Protocols documentation;quality assurance;Quality Control;Recovery;Reporting;resilience;Resources;Respondent;response;Safety;Site;skills;Strategic Planning;Structure;Students;Substance abuse problem;Suicide;Suicide prevention;Surveillance Program;Surveys;Tablets;Target Populations;Techniques;Technology;tool;Training;Training and Education;Training Programs;Training Support;U-Series Cooperative Agreements;Underserved Population;Update;volunteer;web app;Work;worker safety

PROJECT_TITLE: IAFF HazMat Worker Health & Safety Training


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This proposal will develop powerful and interpretable statistical methods for elucidating regulatory mechanisms and functional impacts of transcriptome variation at population and single-cell scales. Our unified framework for associating genetic variants with transcript variants (reflected by changes in a gene’s isoform abundances) will lead to a more powerful and accurate elucidation of the molecular mechanisms of disease/trait-associated genetic variants found by the genome-wide association studies. Our novel methods for studying temporal gene expression dynamics at the single-cell level will allow the interrogation of cellular heterogeneity in biological processes such as immune responses and carcinogenesis, and our simulator will support the systematic evaluation of computational tools for single-cell research.

PI_NAMEs: LI, JINGYI JESSICA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: Address;Benchmarking;Biological Process;carcinogenesis;Cell Count;Cells;computerized tools;Computing Methodologies;Data;Databases;differential expression;Disease;Evaluation;Exons;gene discovery;Gene Expression;Gene Expression Profiling;Generations;Genes;genetic variant;genome wide association study;Genotype;Genotype-Tissue Expression Project;Heterogeneity;Immune response;improved;Introns;Libraries;Macrophage;Methods;Molecular;molecular phenotype;novel;Polyadenylation;Population;Process;Protein Isoforms;Reproducibility;Research;RNA;single-cell RNA sequencing;Statistical Methods;Statistical Models;Techniques;Testing;Time;trait;Transcript;transcriptome;transcriptome sequencing;Uncertainty;Variant

PROJECT_TITLE: Statistical methods for elucidating regulatory mechanisms and functional impacts of transcriptome variation at population and single-cell scales

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-S(55)R]


NIH_SPENDING_CATS: Prevention;Social Determinants of Health

PI_NAMEs: SMITH, JOSHUA  (contact)

PROJECT_TERMS: Address;Aging;behavioral health;Benchmarking;built environment;cancer risk;Chemicals;Collaborations;Communication;Communities;community partners;Complex;Confined Spaces;Conscious;Coordination and Collaboration;Course Content;Data;Databases;Dedications;Development;Discipline;Disease;Educational Curriculum;Effectiveness;Electronics;Emergency response;Emergency Situation;Ensure;Evaluation;Event;evidence base;Face;Fire - disasters;fire fighter;first responder;Goals;Grant;hazardous materials disaster;hazardous materials worker;Hazardous Substances;Hazardous Waste;Health;Health protection;health training;high risk;Hour;Human Resources;Improve Access;improved;Industrialization;Infrastructure;Injury;innovation;instructor;International;Knowledge;Law Enforcement;Learning;Libraries;manufacturing process;Maps;Measures;member;Modeling;National Institute of Environmental Health Sciences;new technology;Occupational Malignant Neoplasm;Occupations;outreach;Performance;Population;Population Growth;prevent;Privatization;Probability;Program Evaluation;Program Reviews;Program Sustainability;programs;Property;Protocols documentation;Provider;Public Health;quality assurance;Recording of previous events;Recovery;Reporting;resilience;Resources;response;Risk;role model;Safety;Strategic Planning;stressor;Structure;Students;Substance abuse problem;Surveillance Program;Surveys;Tablets;Target Populations;Technology;tool;Trainers Training;Training;Training Programs;Transportation;U-Series Cooperative Agreements;Underserved Population;Update;web app;Work;worker safety

PROJECT_TITLE: IAFF Hazardous Waste Worker Training


NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health;Prevention;Suicide;Suicide Prevention

PROJECT_TERMS: Address;Awareness;Behavioral;behavioral health;Benchmarking;Censuses;Cessation of life;Communications Media;Communities;Conscious;Data;Databases;Dedications;Disasters;Disease;E-learning;Education;Educational Curriculum;Effectiveness;Electronics;Emergency Situation;Ensure;Environment;Evaluation;Fire - disasters;first responder;Funding;Goals;Grant;hazard;hazardous materials disaster;hazardous materials worker;Health;Improve Access;improved;Individual;Industrialization;Injury;innovation;instructor;International;Law Enforcement;Learning;Libraries;Maps;Measures;member;National Institute of Environmental Health Sciences;new technology;Occupations;Online Systems;Opioid;peer support;Performance;Persons;Population;Post-Traumatic Stress Disorders;Prevention;Privatization;Process;Program Description;Program Evaluation;programs;promote resilience;Protocols documentation;Provider;quality assurance;Readiness;Recovery;Reporting;resilience;Resources;response;Risk;Risk Assessment;Risk Reduction;role model;Safety;social media;Students;Substance abuse problem;Suicide;Suicide prevention;Surveillance Program;Tablets;Target Populations;Technology;Time;tool;Training;Training Programs;Training Support;Transportation;U-Series Cooperative Agreements;Underserved Population;Update;web app;worker safety

PROJECT_TITLE: IAFF Hazardous Disaster Preparedness Training Program


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: KARCH, CELESTE MARIE (contact)

PROJECT_TERMS: 3-Dimensional;Address;Affect;African American;Aging;aging related;Alzheimer's Disease;Apolipoprotein E;apolipoprotein E-1;Astrocytes;biobank;Biochemical;Biochemistry;Bioinformatics;Biological Models;Biology;Biometry;Blood Vessels;brain cell;Cell Physiology;cell type;Cells;cerebrovascular;Cerebrum;cohort;Collaborations;Collection;Communities;Complement;CRISPR/Cas technology;Culture Media;Data;data management;Dermal;Disease;engineered stem cells;Ethnic Origin;Ethnic Population;Event;Fibroblasts;Gene Expression;Genome engineering;Genotype;Goals;Hispanic;Human;human induced pluripotent stem cells;human stem cells;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Institution;Knowledge;Laboratories;lipidomics;Lipoproteins;metabolomics;Microglia;Modeling;Molecular;Multiomic Data;multiple omics;Mutation;neuroinflammation;Neurons;Nucleosome Core Particle;Organoids;Outcome;Participant;particle;Pathogenicity;Pathologic;Patients;Peripheral Blood Mononuclear Cell;Phase;Phenotype;Property;Protein Isoforms;Proteomics;Protocols documentation;Reproducibility;Research;Resources;Series;sex;Site;Somatic Cell;Source;stem cell model;stem cells;Structural Models;Synapses;Techniques;Technology;Testing;Training;transcriptomics;TREM2 gene;Work

PROJECT_TITLE: Human iPSC Models Core


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Stroke

ORG_CITY: ANN ARBOR

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project narrative Delay to hospital presentation after stroke symptom onset prevents African American patients from being eligible for stroke treatments that reduce disability. Previous educational interventions designed to educate African American patients about stroke and the importance of calling 911 have mostly been delivered community-wide or in a group format, settings that do not adequately address individual reasons for hospital delay. This project will determine whether delivering stroke education individually to African Americans at high risk for stroke improves recognition of stroke symptoms and intent to call 911 if stroke symptoms should occur.

PI_NAMEs: SPRINGER, MELLANIE V (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: 911 call;Accident and Emergency department;acute stroke;Address;African American;African American population;Alteplase;Attitude;Behavior Therapy;Behavioral;burden of chronic illness;career;career development;Child;Church;Cities;Clinic;clinical practice;Clinical Trials Design;Collaborations;Communities;community based participatory research;community partnership;comparison control;comparison intervention;Dedications;design;Development Plans;disability;Education;educational atmosphere;Educational Intervention;Educational process of instructing;Educational workshop;efficacy testing;Eligibility Determination;Emergency Department patient;Emergency department visit;Emergency Nursing;experience;Feedback;Freedom;Funding;Future;Goals;health equity;Health system;healthy lifestyle;high risk;Hospitals;Hour;Imaging technology;implementation science;improved;Individual;innovation;Intervention;intervention delivery;Interview;Intravenous;Measures;Mediating;Medical;Medical center;member;Mentors;Mentorship;Methods;Michigan;multiple chronic conditions;Neurology;novel;Participant;Patients;Perfusion;Phase;Population;post intervention;post stroke;practical application;prevent;primary outcome;Provider;Race;racial difference;racial disparity;racial population;Randomized;randomized controlled design;randomized, clinical trials;Randomized, Controlled Trials;Readiness;Research;Research Personnel;Resources;response;safety net;scale up;secondary outcome;skills;Societies;Stroke;stroke education;stroke incidence;stroke intervention;stroke risk;stroke symptom;stroke therapy;Structure;success;Testing;therapy design;Time;Translating;United States National Institutes of Health;Universities;vascular risk factor;X-Ray Computed Tomography

PROJECT_TITLE: Partnering with an Urban Safety Net Hospital to Deliver Stroke Preparedness in the Emergency Department


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Brain image data collected by the neuroscience community will continue to grow dramatically over the next 5-10 years. Increases in data volume will come from a push to image physically larger volumes such as whole brains from humans (and other primates) and from higher speed for smaller specimens. The Brain Image Library (BIL) is an important public resource for sharing this data by providing a persistent and scalable repository for microscopy data generated by brain researchers.

PI_NAMEs: BRUCHEZ, MARCEL P;ROPELEWSKI, ALEXANDER J (contact);WATSON, ALAN MICHAEL

PROGRAM_OFFICER_NAME: KIM, DOUGLAS SUN-IL

PROJECT_TERMS: archive data;Archives;Atlases;Brain;Brain imaging;BRAIN initiative;brain size;Cells;Censuses;Collaborations;Collection;Communities;Computer software;computerized tools;computing resources;cost;cost effective;Data;data archive;data curation;data exchange;data exploration;data harmonization;data library;data reuse;Data Set;data sharing;data sharing networks;Deposition;Ecosystem;Environment;expectation;experimental study;flexibility;Fluorescence Microscopy;Funding Agency;Goals;High Performance Computing;Human;Image;image archival system;improved;Individual;Infrastructure;Link;Machine Learning;meetings;Meta-Analysis;Metadata;Microscope;microscopic imaging;Microscopy;Morphology;Mus;Neurons;Neurosciences;Neurosciences Research;novel;Outcome;Performance;petabyte;Policies;Primates;Process;Provider;repository;Research;Research Personnel;Resources;Retrieval;Role;Scientist;Secure;Services;shared repository;Specimen;Speed;Standardization;System;Time;Training;transcriptomics;United States National Institutes of Health;Visualization;Visualization software

PROJECT_TITLE: A Confocal Fluorescence Microscopy Brain Data Archive


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Precision Medicine

PI_NAMEs: PENG, JUNMIN  (contact)

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Aging;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Apolipoprotein E;aqueous;Biology;Brain;candidate marker;Cell model;Cells;Cerebrospinal Fluid;Chemicals;Clinical;clinically relevant;Collaborations;Communities;Complex;Coupled;Data Set;Derivation procedure;Diagnosis;Disease;disease heterogeneity;Disease Progression;DNA;Evaluation;Functional disorder;Genotype;Goals;Human;human tissue;improved;innovation;Knock-in Mouse;Label;Libraries;Link;lipidome;lipidomics;Lipids;Mass Spectrum Analysis;metabolome;metabolomics;Methods;Molecular;mouse model;multidisciplinary;Multiomic Data;multiple omics;Mus;nanoscale;Nerve Degeneration;novel;Organoids;Pathogenesis;Pathogenicity;Pathway interactions;Phase;Phosphorylation;Post-Translational Protein Processing;potential biomarker;pre-clinical;prevent;protein complex;Protein Isoforms;Proteins;Proteome;Proteomics;Reagent;Research;Research Personnel;RNA;RNA Splicing;Role;Running;Sampling;Serum;sex;Shotguns;Spliceosomes;Technology;transcriptome;U1 Small Nuclear Ribonucleoprotein

PROJECT_TITLE: Multi-Omics Core


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Disability Research;Dissemination and Implementation Research;Health Services;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: Project Narrative Despite strong consensus that early, specialized intervention for children with Autism Spectrum Disorder (ASD) can have a dramatic impact on outcomes, the public health system’s capacity to provide such services is severely challenged by the rapid rise in ASD prevalence. The goal of this research is to increase timely and equitable access to ASD-specialized early intervention during the critical first three years of life by capitalizing on the existing infrastructure of the Part C Early Intervention (EI) system, which is publicly funded and available in all U.S. States. This project will train EI providers to use an evidence-based, inexpensive, parent-mediated intervention that can improve child and family outcomes as well as mitigate the substantial economic costs associated with ASD.

PI_NAMEs: WAINER, ALLISON LEIGH (contact)

PROGRAM_OFFICER_NAME: PUGLIESE, CARA ELISABETH

PROJECT_TERMS: acceptability and feasibility;Address;Aftercare;Age;Area;autism spectrum disorder;autism symptoms;autistic children;Behavior;Behavior Therapy;Birth;Characteristics;Child;Child Language;Child Rearing;clinically relevant;Code;Consensus;Consensus Development;Consultations;Data;data management;Development;Developmental Delay Disorders;Developmental Disabilities;dosage;Early Intervention;economic cost;Educational process of instructing;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness/implementation design;effectiveness/implementation hybrid;Equity;evidence base;Evidence based intervention;Family;Family member;follow-up;Funding;Future;Goals;Health system;Heterogeneity;Home;hybrid type 1 design;Hybrids;implementation determinants;implementation evaluation;improved;improved outcome;Individuals with Disabilities Education Act;Infrastructure;innovation;Intervention;intervention program;Interview;joint attention;Language;Language Development;language outcome;Lead;Learning;Life;Measures;Mediating;member;Methods;Modification;Motor;multi-site trial;National Institute of Mental Health;Outcome;Parents;Patient Self-Report;Personal Satisfaction;Play;Population;Prevalence;Procedures;Protocols documentation;Provider;provider intervention;Public Health;quality assurance;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research;Role;Sample Size;Sampling;Self Efficacy;service delivery;service intervention;Services;Site;social communication;Source;Stress;System;Technology Assessment;Testing;Training;treatment as usual;treatment effect;Variant

PROJECT_TITLE: 3/4: Improving the Part C Early Intervention Service Delivery System for Children with ASD: A Randomized Clinical Trial


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Data Science;Dementia;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative

PI_NAMEs: ASMANN, YAN W. (contact)

PROJECT_TERMS: Address;Age-associated memory impairment;Aging;aging mechanism;Algorithms;Alzheimer's Disease;analytical tool;Apolipoprotein E;Area;Automobile Driving;Bioinformatics;Biology;Biometry;Cells;Cognitive;Collaborations;Communities;Computer software;Data;Data Analyses;Data Element;data format;data handling;data integration;data management;data modalities;data portal;data quality;Data Security;Data Set;data sharing;Database Management Systems;Databases;Dedications;deep learning;design;Dictionary;digital pathology;Disease;Ensure;Fostering;Funding;Genes;Genotype;Guidelines;Institution;Investigation;Knowledge;Lead;lipidomics;Lipids;Machine Learning;Measures;metabolomics;Metadata;method development;Methodology;Methods;Modeling;Molecular;Monitor;multimodality;Multiomic Data;multiple omics;novel;Outcome Study;Pathway interactions;phenotypic data;Play;Policies;Population Genetics;Preparation;Problem Solving;Process;programs;Proteins;Proteome;Proteomics;Publications;Quality Control;Research;Research Design;Resolution;Resources;Role;Sampling;Scientist;Standardization;Statistical Models;structural biology;System;Testing;Time;Tissues;transcriptome;transcriptomics;United States National Institutes of Health;web portal;Work

PROJECT_TITLE: Bioinformatics, Biostatistics, and Data Management Core