NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI CORAL GABLES

ORG_STATE: FL

PHR: Project Narrative The increasing number of cancer survivors and a growing need for oncologiy care teams to focus on acute cancer care have created the necessity to shift long-term survivorship care to primary care settings. There is very limited work that has integrated and rigorously assessed evidence-based survivorship care programs in Federally Qualified Health Centers that provide primary care mostly to racial/ethnic minority, underserved and other communities with limited financial resources and multiple contextual barriers that can compromise health outcomes. Findings from this study have the potential to disseminate scalable survivorship programs that reach underrepresented and underserved diverse communities with very limited financial and survivorship care resources and a disparate cancer burden, and favorably impact patient and health system outcomes.

PI_NAMEs: LAWRENCE, JOYCELYN ;PENEDO, FRANK J (contact)

PROGRAM_OFFICER_NAME: ETON, DAVID T

PROJECT_TERMS: Acute;Address;Adherence;Adult;Anxiety;Area;Attention;Behavior;Behavior Therapy;Black race;Cancer Burden;cancer care;cancer education;cancer health disparity;Cancer Survivor;Cancer Survivorship;cancer survivorship care;cancer type;care coordination;care systems;Caring;Chronic;Clinic;Cluster randomized trial;Collaborations;Communication;Communities;community based research;community clinic;comorbidity;Complex;Computerized Medical Record;Critical Care;dissemination science;Distress;Early Diagnosis;Early treatment;Education;effectiveness evaluation;effectiveness/implementation design;effectiveness/implementation study;Environment;ethnic diversity;ethnic minority;Evaluation;evidence base;Evidence based intervention;Evidence based program;Fatigue;Federally Qualified Health Center;Florida;follow-up;Future;Guidelines;Health;health care service utilization;health related quality of life;Health Services Accessibility;Health Services Research;Health system;Healthcare;Hispanic;Household;human old age (65+);implementation evaluation;implementation science;implementation/effectiveness;improved;Income;Informatics;Infrastructure;Internet;Intervention;Joints;Life Style;Link;Long Term Survivorship;low socioeconomic status;Malignant Neoplasms;Medical Informatics;Medical Oncology;Mental Depression;mHealth;minority health;Morbidity - disease rate;mortality;neighborhood safety;nutrition;Oncologist;Oncology;oncology service;Outcome;Pain;Patient Outcomes Assessments;patient portal;patient subsets;Patients;Physical activity;Population;Practice Guidelines;Prevention;Primary Care;primary care clinic;primary care clinician;primary care practice;primary care setting;primary health service;primary outcome;Printing;Process;programs;Provider;psychologic;psychosocial;Quality of Care;racial diversity;racial minority;randomized, clinical trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Recurrence;Research;Research Design;Resources;risk stratification;safety net;satisfaction;Science;screening;Second Primary Cancers;secondary outcome;sedentary activity;Self Management;side effect;social;Spanish;Spirituality;standard of care;Survivors;survivorship;Symptom Burden;System;technology validation;tool;Training;Training Programs;Treatment Efficacy;trial design;Work

PROJECT_TITLE: Implementation of Comprehensive Survivorship Care Intervention Across FQHC-Based Primary Care Practices

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (J1)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Obesity

ORG_CITY: ANN ARBOR

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Metabolic dysfunction-associated steatotic liver disease (MASLD) – previously termed nonalcoholic fatty liver disease (NAFLD) – is now the most common chronic liver disease in the world, estimated to affect nearly one- third of the world’s adult population, with an incidence that is projected to continue growing over the next several decades. Yet, available medical therapies for MASLD are quite limited in number and efficacy. This proposal aims to use a combination of in vitro models, biochemical techniques, and human genetics to explore how nuclear envelope defects contribute to MASLD pathophysiology and to establish avenues for the development of novel nuclear envelope-targeted therapies, with the potential to benefit millions of people affected by this disease.

PI_NAMEs: BRADY, GRAHAM F. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Adipocytes;Adipose tissue;Adult;Affect;Area;Automobile Driving;biobank;Biochemical;Cell Line;cell type;Cells;Charge;Chromatin;chronic liver disease;Cirrhosis;Code;cohort;Complex;Cytoskeleton;Data;Data Discovery;Data Set;Defect;Development;Disease;early onset;effective therapy;exome;Fatty Liver;Functional disorder;Funding;Gene Frequency;Genes;Genetic;Genetic Transcription;genetic variant;Genome;Genomics;Goals;Hepatocyte;hepatoma cell;Histologic;HIV-Associated Lipodystrophy Syndrome;Homeostasis;Human Genetics;in vitro Model;in vivo;Incidence;Individual;Insulin Resistance;insulin sensitivity;Laboratories;Lamin Type A;large datasets;Link;lipid metabolism;Lipids;Lipodystrophy;Liver;Liver diseases;liver transplantation;Medical;Membrane Proteins;Metabolic;Metabolic Diseases;Metabolic dysfunction;Metabolic Pathway;Michigan;Minor;Morbidity - disease rate;mortality;mouse model;National Institute of Diabetes and Digestive and Kidney Diseases;new therapeutic target;non-alcoholic fatty liver disease;novel;novel therapeutics;Nuclear Envelope;Nuclear Inner Membrane;Nuclear Lamina;Nucleoplasm;Obesity associated liver disease;obesity genetics;Participant;Pathway interactions;Persons;Play;Population;protective effect;Proteins;rare variant;RNA Transport;Role;Siblings;Steatohepatitis;Structure;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;Tissues;trait;Transfection;Twin Multiple Birth;United States;Validation;Variant;Work

PROJECT_TITLE: Role of SUN1 in MASLD and metabolic disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Nutrition;Obesity;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The objectives of this proposal are to examine the extent to which household food insecurity and neighborhood food access contribute to increasing childhood obesity prevalence (Aim 1), test a meal kit delivery intervention in families and children with food insecurity and obesity (Aim 2), and explore the facilitators and barriers associated with the intervention’s implementation (Aim 3). This research will lay the groundwork to engage families, payers, policymakers, and other stakeholders to support and invest in nutrition security in children to treat and prevent obesity and other nutritional disorders over the life course. This career development award will support Dr. Allison Wu, a pediatric gastroenterologist and health services researcher, in her transition to research independence through mentorship and training in advanced quantitative analyses, clinical trials, qualitative methods, and implementation science.

PI_NAMEs: WU, ALLISON JANE (contact)

PROGRAM_OFFICER_NAME: SERRANO, KATRINA JANE

PROJECT_TERMS: Address;Adherence;Adult;Behavioral;Black race;Body mass index;Boston;cardiometabolism;Caregivers;Child;Child Health;Child Nutrition;Childhood;Chronic Disease;Clinical Research;Clinical Trials;comparison control;contextual factors;cooking;Cross-Over Trials;Data;Diabetes Mellitus;Diet;dietary;Dietary Intervention;Disparity;Eating;Education;Effectiveness;Eligibility Determination;Ensure;Environment;Epidemiology;evidence base;Evidence based intervention;experience;Family;Food;Food Access;food environment;food insecurity;food security;Foundations;Gastroenterologist;Gastroenterology;Goals;Health;Health behavior;health care service utilization;health equity;Health Food;Health Services;Health Services Research;Healthcare Systems;High Prevalence;Hispanic;Home;Household;implementation intervention;implementation science;improved;innovation;Instruction;Intervention;intervention delivery;Intervention Trial;Interview;Investments;K-Series Research Career Programs;Knowledge;Life;Life Cycle Stages;life span;lifestyle intervention;longitudinal analysis;longitudinal dataset;Low Income Population;Medicaid;Medical;medical schools;Medicine;Mentors;Mentorship;middle childhood;multilevel analysis;National Institute of Diabetes and Digestive and Kidney Diseases;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutrition Disorders;Obesity;obesity in children;obesity prevention;obesity treatment;Pediatric Hospitals;Phase;phase I trial;Phase II Clinical Trials;Physicians;Policies;Policy Maker;Population;Population Heterogeneity;Preparation;Prevalence;prevent;programs;Public Health;Qualitative Methods;Qualitative Research;Quality of life;Randomized;Recipe;recruit;Research;Research Activity;Research Personnel;response;Risk;Risk Factors;routine practice;Safety;Scientist;Security;social;Source;Specialist;Testing;Training;Training Activity;Translating

PROJECT_TITLE: Intervening in Food Insecurity to Reduce and Mitigate (InFoRM) Childhood Obesity


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Infectious Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: RELEVANCE (See instruction Anti-HIV-1 drugs prevent HIV-1-infected people from developing AIDS but the drugs do not cure infection because  HIV-1 becomes a permanent genetic element in human chromosomes that is called a provirus. We discovered that  host cell proteins called the HUSH complex silence the HIV-1 provirus, making it difficult for drugs, or the immune  system, to detect and eliminate the virus. The experiments proposed here, which are intended to better understand  how the HUSH silences the HIV-1 provirus, are hoped to provide information that will facilitate efforts to Cure HIV-1  infection.

PI_NAMEs: LUBAN, JEREMY  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 3-Dimensional;Acquired Immunodeficiency Syndrome;Anti-HIV Agents;antiretroviral therapy;Applications Grants;ATAC-seq;Base Sequence;Biochemical;Biological Assay;Candidate Disease Gene;CD34 gene;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Chimeric Proteins;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;Complex;CRISPR interference;Detection;Development;DNA Polymerase II;DNA Sequence;Endogenous Retroviruses;Engineering;Essential Genes;Excision;Experimental Models;experimental study;FLT3 ligand;Gene Silencing;Genes;genetic element;Genetic Transcription;Genome;genome-wide;Glean;Goals;Hematopoietic stem cells;histone modification;HIV;HIV-1;Human;Human Chromosomes;humanized mouse;Immune system;Immunological Models;in vivo;Infection;Instruction;Integration Host Factors;Intervention;Introns;Jurkat Cells;knock-down;Knock-out;Learning;Length;Location;loss of function;Maps;Mediating;memory CD4 T lymphocyte;Metabolism;Methods;Mus;Mutate;novel strategies;Nucleotides;Open Reading Frames;Orthologous Gene;paralogous gene;Persons;Pharmaceutical Preparations;Phenotype;Phylogeny;posttranscriptional;pressure;prevent;Primate Lentiviruses;promoter;Promoter Regions;Proteins;Proteomics;Proviruses;reconstitution;Reporter;Resistance;resistance mechanism;Retroviridae;RNA;RNA Binding;Role;screening;stem;T-Lymphocyte;Testing;Transcript;Transcription Initiation Site;transcriptome sequencing;Transgenes;Translations;Viral;Viral Proteins;Viremia;Virus

PROJECT_TITLE: The HUSH complex in HIV-1 latency

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences

ORG_CITY: STONY BROOK

ORG_DEPT: PSYCHIATRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Obsessive-compulsive disorder (OCD) is a chronic, prevalent and disabling condition. The goal of this application is to provide initial proof-of-concept for involvement of the cholinergic system in OCD, based on exciting novel observations in mouse models. Based on these observations we will measure cholinergic release capacity in OCD, relate it to symptoms in patients and compare it to healthy controls.

PI_NAMEs: ABI-DARGHAM, ANISSA  (contact);PLOTKIN, JOSHUA L

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: acetylcholine transporter;Adult;Agreement;Behavior;cholinergic;Chronic;Clinical Services;Collaborations;Computerized Medical Record;Corpus striatum structure;Data;density;design;Development;Disabling condition;Disease;disease model;Dorsal;Electronic Health Record;Face;Functional disorder;Genetic;Goals;Health;high reward;high risk;improved;inhibitor therapy;Institution;interest;Interneurons;Intervention;Investigation;Kinetics;knock-down;Knockout Mice;Link;Measures;Medicine;Modeling;motor behavior;mouse model;Mus;new therapeutic target;New York;novel;novel therapeutics;Obsessive compulsive behavior;Obsessive-Compulsive Disorder;Patients;Pharmaceutical Preparations;Pilot Projects;Positron-Emission Tomography;Property;Proteins;PSD-95-associated protein;Psychiatry;Quality of life;radiotracer;recruit;Research;Research Personnel;Residual state;Scanning;Selective Serotonin Reuptake Inhibitor;Severities;Symptoms;System;Testing;Therapeutic Intervention;Tracer;Translational Research;transmission process;United States Food and Drug Administration;Universities;Up-Regulation;Viral;Work

PROJECT_TITLE: Exploratory study of the cholinergic system in Obsessive Compulsive Disorder (OCD)

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Racial and Ethnic Minority Health Research

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE This study aims to better understand how to deliver culturally sensitive care management for hospice care transitions involving racially and ethnically diverse persons living with the dementia and their care partners in home healthcare to generate needed evidence that can help reduce inequities in hospice use at the end of life. Informed by the National Institute on Aging Health Disparities Research and the Equity-Focus Implementation Research frameworks, this study aims to codesign and pilot test a culturally sensitive transitional care management checklist intervention to improve hospice transitions for Black, Latino, and Asian persons living with dementia and their care partners in home healthcare. Findings from this study will inform future transitional care interventions that can meet the needs of racially and ethnically diverse persons living with dementia surrounding hospice transitions and can be adapted for other healthcare settings.

PI_NAMEs: MURALI, KOMAL PATEL (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Administrator;Admission activity;Adult;advanced dementia;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;arm;Asian;Asian population;Award;Black Populations;Black race;care coordination;career development;caregiving;Caring;Case Manager;Clinical;Clinical Trials;collaboratory;Communication;Data;Decision Making;Dementia;design;Development;Diagnosis;Disparity;disparity reduction;Doctor of Philosophy;Education;electronic health data;Electronic Health Record;Eligibility Determination;Emergency department visit;end of life;end of life care;Enrollment;Equity;ethnic diversity;evidence base;experience;Feedback;Focus Groups;follow-up;Future;Goals;health care service utilization;health care settings;Health Disparities Research;health disparity;health equity;Health equity research;Health Professional;Healthcare;Home;Home Care Services;Home Health Care Agencies;Hospice Care;hospice environment;hospice utilization;Hospitalization;Hospitals;implementation framework;improved;Individual;Inequity;Inpatients;Intake;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Latino;Latino Population;Life;Managed Care;Manuscripts;Measurement;Measures;Medical;Medicare;meetings;Mentored Patient-Oriented Research Career Development Award;Mentors;Methods;Modeling;National Institute on Aging;New York City;Nurse Practitioners;Nurses;Outcome;outcome disparities;outreach;Pathway interactions;Patient Preferences;Patients;Persons;Physicians;pilot test;pilot trial;Practice Management;preference;Preparation;primary outcome;Provider;Quality of Care;Quality of life;racial diversity;Religion;Religious Belief;Reporting;Research;research and development;Research Personnel;Research Training;Resources;Sample Size;Sampling;satisfaction;Scientist;Service delivery model;Social Workers;Spirituality;stem;Structure;systematic review;Telephone;therapy development;Time;tool;Training;treatment as usual;United States;United States National Institutes of Health;usability;Work

PROJECT_TITLE: Engage-D: DEsigNing Culturally Sensitive Care ManaGement for Hospice TrAnsitions for Diverse Persons LivinG with AdvancEd Dementia

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Nutrition;Obesity;Pancreatic Cancer;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Liver metastasis is the leading cause for the high mortality of pancreatic cancer and is expected to occur more frequently in the growing population with obesity, yet the links between obesity-related fatty liver and metastasis remain largely unknown. This project focuses on identifying mechanisms in the tumor cells and microenvironment that facilitate liver metastasis in obesity. These studies will improve our understanding of the vulnerabilities of liver metastasis arising in a lipid-rich environment, with the ultimate goal of uncovering new targets to effectively treat metastasis in an increasingly common subset of cancer patients.

PI_NAMEs: ZHU, CHANGYU  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Adipose tissue;Advisory Committees;Affect;beta-Hydroxybutyrate;Biological Assay;Cancer Biology;cancer cell;cancer genetics;Cancer Patient;career development;Chromatin;chronic liver disease;Coculture Techniques;collaborative environment;Data;Development Plans;Disease;Disease Progression;Disseminated Malignant Neoplasm;Ecosystem;Environment;Enzymes;Epigenetic Process;epigenome;epigenomics;Exhibits;experience;Faculty;Fatty Acids;Fatty Liver;Foundations;Genetic;Genetic Models for Cancer;Genetic Transcription;Goals;Hepatic;Hepatocyte;High Fat Diet;Histone Acetylation;Human;Immune;immune cell infiltrate;Immunology;improved;Inflammatory;inflammatory milieu;Inflammatory Response;insight;Institution;Interferon Type II;Interferons;IRF1 gene;ketogenesis;Knowledge;Link;Lipase;lipid metabolism;Lipids;Lipolysis;Liver;liver function;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Memorial Sloan-Kettering Cancer Center;Mentors;Metabolic;Metastasis Induction;Metastatic Neoplasm to the Liver;mortality;mouse genetics;mouse model;Neoplasm Metastasis;neoplastic cell;non-alcoholic fatty liver disease;novel therapeutic intervention;Obese Mice;Obesity;Organoids;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;Pathogenesis;Pathway interactions;patient population;Patients;Phase;Population;Positioning Attribute;Postdoctoral Fellow;PPAR delta;Prevention;Production;Prognosis;programs;receptor;Research;research and development;Resources;response;Role;Sampling;Scientist;Shapes;Signal Transduction;Site;Solid;Specimen;support network;targeted treatment;Technology;Testing;Therapeutic;Therapeutic Intervention;tool;Training;transcription factor;Transcriptional Activation;transcriptome sequencing;transcriptomics;tumor;tumor microenvironment;uptake;Vocational Guidance;Work

PROJECT_TITLE: The crosstalk between obesity-induced fatty liver and liver metastasis

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Menopause;Mental Health;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Effective interventions targeting behavior change mechanisms to increase objectively measured physical activity and decrease the negative health impacts during perimenopause are lacking for midlife Hispanic women. This study will incorporate Hispanic women's lived experiences with physical activity participation to develop and evaluate a contextually appropriate physical activity intervention for feasibility. Increasing physical activity during this critical life period will promote health and well-being among midlife Hispanic women in aging.

PI_NAMEs: LORENZO, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: DUTTA, CHHANDA

PROJECT_TERMS: Acceleration;Achievement;Address;Adult;Advanced Development;Age;aged;Aging;aging related;Anxiety;Area;arterial stiffness;Automobile Driving;Award;Behavior;behavior change;Behavioral;Behavioral Mechanisms;Biological Markers;Blood Pressure;blood pressure elevation;Body mass index;C-reactive protein;Cardiovascular Diseases;Central obesity;Clinical;Collaborations;community based participatory research;community engagement;community setting;cultural competence;depressive symptoms;design;Dyslipidemias;effective intervention;efficacy testing;Endocrine;Ensure;Exercise;exercise intervention;experience;feasibility testing;Focus Groups;Foundations;Goals;Guidelines;Health;Health behavior;health disparity;Health Promotion;Hispanic;Hispanic Women;Hour;human old age (65+);Hypertension;improved;Insulin Resistance;Intervention;Intervention Studies;Interview;Knowledge;late life;leadership development;Life;Life Experience;Lipids;Literature;Lived experience;Measures;Menopausal Symptom;Menopause;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;middle age;Midlife women;Modeling;Moods;Not Hispanic or Latino;novel;Obesity;Perimenopause;Personal Satisfaction;Physical activity;Physiological;prevent;psychologic;psychosocial outcome;randomized, clinical trials;Registered nurse;Research;Research Activity;Research Project Grants;Risk;Risk Reduction;Role;sedentary;skills;Sleep;Sleeplessness;social;Structure;Target Populations;Testing;Theoretical model;theories;therapy design;therapy development;Time;Training;Training Activity;Translating;United States National Institutes of Health;Vascular remodeling;Visceral;White Women;Woman

PROJECT_TITLE: No time to pause: Physical activity to improve health and well-being of midlife Hispanic women during the menopausal transition


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

PHR: PROJECT NARRATIVE When patients develop life-threatening organ failure from an infection (sepsis), they often experience severe loss in their muscle mass. We don’t understand what causes this muscle loss, and don’t have any treatments to prevent or reverse it. In this study, we will study gut bacteria and CT images from patients with sepsis to determine how gut bacteria contribute to muscle loss, and how we might soon treat these bacterial communities as a therapeutic target.

PI_NAMEs: DICKSON, ROBERT PICKETT (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acute;Admission activity;Adrenal Cortex Hormones;Affect;Aging;Animal Model;Antibiotics;Atrophic;Attenuated;Bacteria;bacterial community;Biological;Blood;Body Composition;Butyrates;Calibration;candidate identification;Catabolism;Cause of Death;Clinical;Clinical Data;clinically significant;cohort;Cohort Studies;Critical Illness;Data;Data Science;Databases;Development;Exercise;Exhibits;experience;Face;functional status;Genes;gut bacteria;gut microbiome;gut microbiota;Heterogeneity;Hospitalization;Hour;Human;human study;in silico;indexing;Infection;Length of Stay;Life;Lower Gastrointestinal Tract;Metabolic;Metabolic dysfunction;Metabolic Pathway;Metabolism;metagenomic sequencing;microbial;microbiome;microbiota;microbiota composition;mortality;mouse model;Muscle;muscle form;Muscular Atrophy;novel;novel therapeutics;Obesity;Organ;Organ failure;Outcome;Pathogenesis;Pathway interactions;Patient imaging;Patients;Persons;Play;Positioning Attribute;predict clinical outcome;prevent;Prevention;Prevention therapy;prospective;Rectum;repository;Research;Resources;response;Retrospective cohort;Role;Sampling;Sepsis;septic patients;Severities;Skeletal Muscle;skeletal muscle wasting;Subgroup;Survivors;Swab;Syndrome;Techniques;Temperature;Testing;therapeutic target;therapy development;Thinness;Time;Variant;X-Ray Computed Tomography

PROJECT_TITLE: The Gut Microbiome and Acute Muscle Loss in Sepsis

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: HL

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Heart Disease

ORG_CITY: BLACKSBURG

ORG_DEPT: MISCELLANEOUS

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: PROJECNTARRATIVE  for parent grant R01HL156667 TheheacrotnstarnetqluyierneesrtgoyworkM.itochownhdircaihraer,enownaesbdein"gthe powerhofutsheceelslu"p,pcloyntineunoeurtsgotyhceardciealcMlist.ochomnadlrfiuanicstion closleilnytkodeedvelopmenatndddyesffeucnitcntsthiheoenaTrhtia.spplicsaetetikoaosdnvanocuer understoafmnedtianbgroelpircograomftmhhieenagtrhtromuigthochondripaalthwdauyrsing signaling postndaetvaellopamnedpnattholdoegvieclaolpSmpeencti.ftihcipasrlolpyo,wsiaulltlilaigzeenetic modealndstate-of-the-aarptprotaodcehtertmhirnoeloefthneovmeulscle-speci multisystems mitochondriPaelrmi1nmitoch ndriaalndebnieorggeeintnteihshceiessalatnhdyiseased regulator hearts.

PI_NAMEs: DRAKOS, STAVROS GEORGE;WARREN, JUNKO SHIBAYAMA (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TITLE: Perm1 is a Novel Regulator of Cardiac Energetics and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(05)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Diabetes;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Wound Healing and Care

ORG_CITY: INDIANAPOLIS

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Wound healing in diabetic patients is a challenging clinical problem that prohibits them from undergoing major oral surgeries. The proposed study is relevant to public health as it aims to elucidate the impact of diabetes on oral epithelial stem cells and their niche during both homeostasis and wound healing. Completion of this proposal will provide critical, clinically relevant knowledge to improve diabetic wound management.

PI_NAMEs: YUAN, XUE  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: 3-Dimensional;Adult;Advanced Glycosylation End Products;Affect;Apoptosis;Biocompatible Materials;Blood Glucose;Body System;Cell Compartmentation;Cell Differentiation process;Cells;Characteristics;Chronic;Clinical;clinically relevant;Coculture Techniques;Data;design;Development;Diabetes Mellitus;diabetic;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Eating;effective therapy;Epidemic;Epithelial Cell Proliferation;epithelial stem cell;epithelial wound;Epithelium;Exhibits;Functional disorder;Future;Goals;healing;Health;Hematopoietic stem cells;Homeostasis;Impaired wound healing;Impairment;improved;In Vitro;in vivo Model;Inflammation;Injury;innovation;Knowledge;Lesion;Life;Light;limbal;Mesenchymal Stem Cells;Metabolic;migration;Modeling;Monitor;multiorgan damage;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;notch protein;novel;Oral;Oral cavity;oral cavity epithelium;Oral Characters;oral lesion;Oral mucous membrane structure;Oral Surgical Procedures;Oral Ulcer;Pathway interactions;Patients;Personal Satisfaction;Persons;Positioning Attribute;Process;Proliferating;protein expression;Public Health;re-epithelialization;receptor for advanced glycation endproducts;Research;response;response to injury;Signal Pathway;Signal Transduction;Sleep;statistics;stem cell fate;stem cell proliferation;stem cells;Stratum Basale;Structural Protein;Time;Tissues;Tooth Extraction;Work;World Health Organization;wound;wound closure;wound healing;wound treatment

PROJECT_TITLE: Epithelial stem cell dysfunction in diabetic oral ulcer

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 YM (09)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Digestive Diseases;Genetics;Liver Cancer;Liver Disease;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Hepatoblastoma is a devastating pediatric cancer with a rapidly growing incidence and dismal survival rate of less than 50% for patients with high-risk disease, including those with treatment refractory, relapse, or metastatic tumors. A major contributor to this poor survival rate is the presence of circulating tumor cells in the form of minimal residual disease that resist chemotherapy, enter blood vessels, survive in circulation, and seed distant sites to generate metastasis. Our study is aimed to define key molecular pathways in these unique, renegade circulating tumor cells and then apply this knowledge to develop targeted therapies to improve survival in patients with high-risk hepatoblastoma.

PI_NAMEs: WOODFIELD, SARAH ELIZABETH (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Affect;Animal Model;Area;Biological Assay;Blood specimen;Blood Vessels;cancer cell;cancer survival;Cell Line;Cell model;Cell Survival;Cells;Chemoresistance;chemotherapy;Childhood Solid Neoplasm;Circulation;Clinical;clinical effect;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Data;design;Disease;disorder risk;Distant;efficacy testing;Exposure to;FRAP1 gene;Gene Expression;Genes;Genetic Transcription;Goals;Hepatoblastoma;high risk;improved;In Vitro;in vitro activity;in vivo;Incidence;inhibitor;innovation;intrahepatic;Invaded;Knowledge;Ligation;Link;liquid biopsy;Literature;Liver;Liver neoplasms;Malignant Childhood Neoplasm;mass spectrometric imaging;metabolic profile;Metabolism;Metastatic Neoplasm to the Lung;metastatic process;migration;Modeling;Molecular;Molecular Profiling;mouse model;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;Nonmetastatic;novel;NQO1 gene;Oncogenic;Operative Surgical Procedures;Outcome;overexpression;Pathway interactions;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Phenotype;Positioning Attribute;Pre-Clinical Model;Precision therapeutics;prevent;Primary Neoplasm;Process;Proto-Oncogene Proteins c-akt;Publishing;Recurrence;Refractory;Regulation;Relapse;Reporter;Residual Neoplasm;Resistance;Role;Sampling;Signal Pathway;single-cell RNA sequencing;Site;small hairpin RNA;small molecule inhibitor;standard of care;success;Survival Rate;targeted treatment;Testing;Therapeutic;Tissues;transcriptomics;Treatment Failure;treatment strategy;tumor;Tumor Cell Migration;Tumor Volume;Tumor Weights;Up-Regulation;Whole Blood;Work

PROJECT_TITLE: High-risk hepatoblastoma dissemination control by oncogenic NRF2

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will lead to the discovery of mechanisms by which intracellular zinc is allocated to metalloenzyme targets. This is expected to lead to increased understanding and new treatments for human diseases impacted by dysregulated zinc homeostasis, such as neurodegenerative disorders. The proposed research is therefore relevant to the part of NIH's mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: MURDOCH, CAITLIN CYNTHIA (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Affect;Animals;Behavior;Binding;Biochemical;Biological Assay;Biological Availability;Biological Markers;Brain;burden of illness;candidate identification;Cell Culture Techniques;Cell Physiology;Cells;cellular development;Central Nervous System;chromatin immunoprecipitation;Client;cofactor;Coupled;Data;Developing Countries;Development;Dietary Zinc;Disease;DNA Binding;DNA Binding Domain;enzyme activity;Enzymes;Eukaryota;experimental study;Family;Fingers;Gene Targeting;Genes;Genetic;Genetic Transcription;Goals;Guanosine Triphosphate Phosphohydrolases;Health;Histopathology;Homeostasis;Human;human disease;Immunoprecipitation;In Vitro;in vivo;Incubated;Inductively Coupled Plasma Mass Spectrometry;Ions;Knowledge;Label;Life;loss of function;Maintenance;Mediating;metalloenzyme;Metalloproteins;Metals;Micronutrients;migration;Mission;Modeling;Molecular;Monitor;mortality;Mus;mutant;Names;Nature;Nerve Degeneration;nervous system development;Nervous System Disorder;Nervous System Physiology;Neurodegenerative Disorders;neurogenesis;Neurologic;neuron development;Neurons;Neuropeptides;Outcome;Oxidative Stress;Pathogenesis;Pathology;Pathway interactions;pharmacologic;Phenotype;Physiological;Physiology;Population;Process;protein transport;Proteins;Proteome;Public Health;Reagent;Recombinants;Regulation;Research;response;response to injury;Risk Factors;Role;Signal Pathway;Signal Transduction;Starvation;Stress;Testing;Tissues;transcription factor;transcriptome sequencing;Transgenic Organisms;United States National Institutes of Health;Vertebrates;virtual;Work;Zebrafish;ZFHX3 gene;Zinc;Zinc deficiency;Zinc Fingers

PROJECT_TITLE: Maintenance of brain homeostasis by an ancient zinc metallochaperone

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 TWD-B (KR)]


NIH_SPENDING_CATS: Cancer;Immunotherapy;Skin Cancer

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative Although current immunotherapies have revolutionized the clinical treatment, metastatic melanoma still represents an unmet medical need in clinical therapy, with overall treatment responses of is less than 50%. Our proposal, warranted by our preliminary data, aims to investigate the mechanisms of which mitochondrial complex I inhibition induces a strong anti-tumor immunity. Successful accomplishment of this proposal will identify novel mitochondrial vulnerabilities that cause antitumor immunity and bring a novel therapeutic strategy for melanoma patients.

PI_NAMEs: LIANG, JIAXIN  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: anti-tumor immune response;Antigen Presentation;Award;Betaine;bisulfite sequencing;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Choline;Clinical;Clinical Treatment;Collaborations;Combined Modality Therapy;Communities;Complex;Dana-Farber Cancer Institute;Data;Development Plans;Disease;Down-Regulation;Ectopic Expression;effector T cell;efficacy evaluation;Environment;Enzymes;Evaluation;exhaust;Experimental Designs;formyl peptide;Future;glycine dehydrogenase;Goals;Immune;Immune checkpoint inhibitor;Immune response;Immunocompetent;immunogenic;immunogenicity;Immunologic Surveillance;Immunology;immunoregulation;Immunotherapeutic agent;Immunotherapy;Impairment;improved;In Vitro;in vitro activity;Institution;Intrinsic drive;ipilimumab;Knock-out;Lecithin;Lesion;Lipids;Manuscripts;Maps;Medical;medical schools;Melanoma;Melanoma Cell;Melanoma patient;Mentorship;Metabolic;Metabolism;metabolomics;Metastatic Melanoma;Methylation;Mitochondria;mitochondrial metabolism;Modeling;Monoclonal Antibodies;Mus;NADH;neoplastic cell;Nivolumab;novel;novel therapeutic intervention;Outcome;Pathway interactions;patient response;Peptides;Phase;Phosphatidylcholine Biosynthesis;Play;Post-Translational Protein Processing;pre-clinical;Preparation;Production;Proteins;Proteomics;recruit;Regimen;research and development;Research Personnel;Resistance;response;Role;Sampling;Sarcosine;Site;skills;Students;T-Lymphocyte;tandem mass spectrometry;Testing;Therapeutic;tool;Training;Transplantation;treatment response;treatment strategy;tumor;tumor growth;Tumor Immunity;tumor microenvironment;Tumor-Infiltrating Lymphocytes;Up-Regulation

PROJECT_TITLE: Targeting mitochondrial vulnerabilities to drive intrinsic melanoma immunogenicity


ADMINISTERING_IC: EY

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Visual perceptual learning is one of the most promising visual rehabilitation methods for over 12 million Americans with impaired vision. This project aims to understand how visual perceptual learning can transfer to images and items that were not seen during training and to new locations in the visual field where training did not occur. Results from this work have the potential to greatly improve the efficiency of visual perceptual learning for visual rehabilitation.

PI_NAMEs: ROSEDAHL, LUKE ARTHUR (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: American;Attention;Behavioral;Brain;Brain imaging;career;Categories;Communities;Computer Models;Cues;Data;deep neural network;design;Dimensions;experience;experimental study;Functional Magnetic Resonance Imaging;gamma-Aminobutyric Acid;Goals;Grant;Human;Image;Imaging Techniques;improved;Individual;insight;Job Application;Knowledge;Learning;Location;Magnetic Resonance Spectroscopy;Manuscripts;Measures;Mentors;Methods;Modeling;neural;neural correlate;Neural Network Simulation;neuromechanism;Neurons;Neurotransmitters;novel;oral communication;Perceptual learning;Performance;Persons;Positioning Attribute;predictive modeling;Preparation;Professional Competence;professor;programs;Psychological Transfer;Quality of life;Rehabilitation therapy;Reporting;Research;Resources;Role;Secondary to;Secure;Series;skills;Specificity;Stimulus;Structure;Technical Expertise;Testing;theories;Thick;Training;Universities;Vision;Visual;Visual attention;Visual Fields;Visual impairment;visual learning;visual processing;Work;Writing

PROJECT_TITLE: Mechanisms of Perceptual Learning Transfer

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


NIH_SPENDING_CATS: Autoimmune Disease;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Antibodies produced following vaccination form the basis for protection against viruses and other microbes. B lymphocytes produce protective antibodies after vaccination. Our goal is to analyze a relatively understudied population of B cells following viral infection in mice, to determine how these cells develop in different organs in the body and how they contribute to protection against infection.

PI_NAMEs: CRAFT, JOSEPH EDGAR (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: Address;age related;Aging;Antibodies;Antibody Formation;Antibody Response;Antigens;Autoantibodies;Autoimmune Diseases;Autoimmunity;autoreactive B cell;autoreactivity;B cell differentiation;B-Cell Activation;B-Lymphocyte Subsets;B-Lymphocytes;Bacterial Infections;Blood-Borne Pathogens;Bone Marrow;Cell Compartmentation;cell motility;Cells;Cellular biology;Circulation;cross reactivity;de novo mutation;Development;Early Diagnosis;Equilibrium;Exhibits;experience;Exploratory/Developmental Grant;Exposure to;Frequencies;Generations;Germ Lines;Goals;Human;Humoral Immunities;Immune;Immunoglobulin D;Immunologics;immunopathology;Infection;Infiltration;influenza infection;influenza virus vaccine;Invaded;Investigation;ITGAX gene;Knowledge;Liver;Longevity;Lung;Lymphocytic choriomeningitis virus;Lymphoid;Mediating;Memory;Memory B-Lymphocyte;Microbe;Mus;Mutation;Nature;neutralizing antibody;novel;Organ;pathogen;Pathogenicity;Pathology;Phenotype;Plasma Cells;Population;Population Heterogeneity;Positioning Attribute;Prevalence;Residencies;response;Role;Serum;Signal Transduction;Site;Source;Specificity;Spleen;therapeutic target;Tissues;Vaccination;vaccine development;vaccine-induced antibodies;Vaccines;Viral;Virus;Virus Diseases

PROJECT_TITLE: Atypical B Cells: Origin and Autoreactivity

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


NIH_SPENDING_CATS: Clinical Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: SAN FRANCISCO

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE: The treatment of Spanish-speaking patients with distal radius fractures should be guided by patient reported outcome measures that are both linguistically and culturally adapted. As there are currently no appropriately culturally adapted patient reported outcome measures for Spanish-speaking patients with distal radius fractures, we aim to develop, validate, and pilot test appropriately culturally adapted patient reported outcome measures for two Spanish-speaking populations. The development, validation, and pilot testing of culturally adapted patient reported outcome measures for Spanish-speaking patients with distal radius fractures will yield new tools for doctors to utilize to understand outcomes and guide treatment for patients in the United States and worldwide.

PI_NAMEs: SHAPIRO, LAUREN M (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adult;Affect;American;Area;Articular Range of Motion;care outcomes;career;Caring;clinical care;Clinical Practice Guideline;Code;cognitive interview;cohort;comparative;Complement;cost;Costa Rican;Country;design;Development;Distal;Ensure;Evaluation;Foundations;Fracture;Future;Goals;Hand;Health;Health Status;improved outcome;Information Systems;Injury;International;Interview;Knowledge;Linguistics;Measurement;Measures;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Minority Groups;Morbidity - disease rate;non-Native;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Outcome Assessment;Outcome Measure;Patient Care;Patient Outcomes Assessments;patient population;Patient-Focused Outcomes;Patients;Physical assessment;Physical Function;Pilot Projects;pilot test;pilot trial;Population;Population Heterogeneity;Process;professor;Property;Psychometrics;Quality of Care;Radius Fractures;Randomized, Controlled Trials;Research Design;Research Methodology;Research Personnel;San Francisco;skills;Spanish;Standardization;Structure;Surgeon;systematic review;Target Populations;Testing;tool;Training;Translating;Translation Process;Translations;Treatment outcome;United States;Validation;Work

PROJECT_TITLE: Addressing Cross-Cultural Adaptation of Patient Reported Outcome Measures for Distal Radius Fractures

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative: Long noncoding RNAs (lncRNAs) play a role in many fundamental biological processes and are implicated in human disease, yet few have been characterized to date due to insufficient tools. This proposal describes novel CRISPR-based methodology for lncRNA knockdown, imaging, and interacting protein profiling that will enable high-throughput identification and characterization of functional lncRNAs in human cells. If successful, this study will deepen our understanding of basic lncRNA biology and inform the diagnosis and treatment of associated disease.

PI_NAMEs: COLOGNORI, DAVID  (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: Address;Advisory Committees;Area;Award;Biochemical;Biological;Biological Process;Biology;Biotinylation;candidate identification;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Coupled;CRISPR screen;CRISPR/Cas technology;Cytoplasm;cytotoxicity;Development;Diagnosis;Disease;disease diagnosis;Ensure;Environment;Exhibits;experience;experimental study;Faculty;Fluorescence Microscopy;Foundations;Gene Expression;Gene Expression Regulation;Genes;genetic manipulation;Genetic Transcription;Genomics;Goals;Grant;Health;high throughput screening;high throughput technology;Human;human disease;Image;Image Analysis;in situ sequencing;innovation;interest;Investigation;knock-down;Knowledge;Label;Laboratories;Lentivirus;Libraries;Maps;Mentors;Messenger RNA;Metabolism;Methodology;Methods;Morphology;novel;Nuclear;Pathway interactions;Pattern;Phase;posttranscriptional;Preparation;Protein Analysis;protein profiling;Proteins;Proteomics;Research;RNA;RNA Binding;RNA Sequences;RNA-Protein Interaction;Running;screening;single-cell RNA sequencing;skills;Specificity;Streptavidin;System;Techniques;Technology;tool;trafficking;Training;Transcript;transcriptome;transcriptomics;Untranslated RNA;Visualization;Work;Writing

PROJECT_TITLE: Identification and Characterization of Functional lncRNAs in human cells


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hematology;Rare Diseases;Sickle Cell Disease;Social Determinants of Health;Telehealth

ORG_CITY: PITTSBURGH

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE This study examines patient-provider communication among patients with sickle cell disease and their healthcare providers, and tests a communication tool called SBAR3. This proposal also provides the opportunity for an early-career scientist to get training needed in human-centered design and other qualitative research methods, in patient-provider communication, and in the conduct of multisite randomized controlled trials. Funding for this project is an investment in future research helping adults with sickle cell disease and other chronic diseases care for themselves and talk to healthcare providers about their health.

PI_NAMEs: O'BRIEN, JULIA A (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: acceptability and feasibility;acronyms;Address;Adult;Affect;African ancestry;Ambulatory Care;Analysis of Variance;Assertiveness;attentional control;Behavior;behavior change wheel;Benign;Blood;career;career development;Caring;Chronic Disease;Clinic;Clinical;Code;Communication;Communication Tools;Consent;Control Groups;Data;design;Development;digital health;Discrimination;Disease;Disease Outcome;Education;Educational process of instructing;effectiveness testing;Ensure;Environment;Evaluation;evidence base;Evidence based intervention;experience;Feedback;Focus Groups;Foundations;Funding;Future;Genetic;Genetic Transcription;Health;health care disparity;health disparity;Health Personnel;Health Promotion;Healthcare;Healthcare Systems;Hematological Disease;Hematology;Home;Hour;human centered design;improved;Intervention;Interview;Investments;Knowledge;lens;Life;Managed Care;Maps;Measures;Mentors;Methods;Minority Groups;minority patient;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Outcome;Participant;patient population;patient-clinician communication;Patients;perceived discrimination;Persons;pilot test;Play;poor health outcome;Population;Population Heterogeneity;programs;Provider;provider communication;Qualitative Methods;Qualitative Research;Questionnaires;Race;Randomized;Randomized, Controlled Trials;Readiness;recruit;Research;Research Methodology;Research Personnel;Risk;Role;Roter;satisfaction;Scientist;Secure;Self Care;Self Efficacy;Self Management;Services;shared decision making;Sickle Cell Anemia;Site;skills;social stigma;Structure;Symptom Burden;Symptoms;System;Systems Analysis;Telephone;Testing;theories;Time;tool;Training;Training Activity;treatment adherence;Update;uptake;Work

PROJECT_TITLE: Adaptation and Pilot Testing of a Patient-provider Communication Intervention for Adults with Sickle Cell Disease

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (88)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Cancer;Cancer Genomics;Clinical Research;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Microbiome;Orphan Drug;Patient Safety;Rare Diseases;Wound Healing and Care

ORG_CITY: MILWAUKEE

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative Open surgery for oral (mouth) cancer remains the standard of care but is often complicated by infection after surgery, leading to significant patient harm. However, the source of the bacteria that cause infection is uncertain and the mechanisms of antibiotic resistance have not been established. To address these gaps in knowledge, we propose a study of bacterial genetics and antibiotic resistance during mouth cancer surgery to better understand how infections occur and what we can do to prevent them in the future.

PI_NAMEs: ZENGA, JOSEPH  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Ampicillin;Antibiotic Resistance;Antibiotic-resistant organism;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Bacterial DNA;bacterial genetics;Blood;bone;Bone necrosis;Cancer Control;Cancer Patient;cancer surgery;case-based;clinical risk;Complex;cost;Cryopreservation;Data;design;Development;Drug Kinetics;Environment;Esophagus;Etiology;Evaluation;Excision;experience;Fibrosis;Financial Hardship;Foundations;Future;genetic resistance;Genome;genome sequencing;Genomics;Genus staphylococcus;Health Care Costs;high risk;hospital readmission;improved;inclusion criteria;Infection;Infectious Agent;Inpatients;Intervention;Knowledge;Lead;Local Anti-Infective Agents;malignant mouth neoplasm;Malignant Neoplasms;Mandible;Maps;Measures;metagenomic sequencing;Metagenomics;Methods;microbial;microbial genomics;microbiota;Minimum Inhibitory Concentration measurement;Mouth Diseases;Nasal cavity;Operative Surgical Procedures;Oral;oral bacteria;Oral cavity;oral commensal;oral condition;oral microbial community;oral microbiome;oral pathogen;Oral Surgical Procedures;Organism;pathogen;pathogenic bacteria;Pathway interactions;Patients;Pattern;Penetration;Perioperative;perioperative morbidity;Plasma;Postoperative Period;Precision therapeutics;prevent;prophylactic;prospective;Pseudomonas;Pseudomonas aeruginosa;psychosocial;Radiation;rational design;reconstruction;recruit;Rehabilitation therapy;Reporting;Resistance;Resistance development;resistance gene;resistance mechanism;Risk Factors;Role;Sampling;Site;Skin;Source;standard of care;Staphylococcus aureus;Structure;Sulbactam;Surgical wound;Surgical Wound Infection;Swab;Techniques;Testing;Therapeutic;Tissue Sample;Tissues;Tongue;Transplantation;Trauma;treatment duration;Vascularization;whole genome;wound bed

PROJECT_TITLE: Defining the mechanisms of surgical site infection after oral cancer surgery using peri-operative metagenomics


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Age-related macular degeneration is the leading cause of vision loss in the elderly in industrialized nations. The majority of patients suffer from the early and intermediate “dry” form of the disease and are without treatment options. In this training grant proposal, we have developed a mentored training plan in glycobiology to understand the extracellular matrix dysregulation responsible for initiating AMD and inform the development of novel therapeutics.

PI_NAMEs: TOOMEY, CHRISTOPHER B (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Address;Affect;Age;age effect;age related;age related biomarkers;Age related macular degeneration;aged;Aging;Apolipoprotein E;apolipoprotein E-4;Apolipoproteins;Applications Grants;Atherosclerosis;Basal lamina;Binding;Binding Sites;Biogenesis;Biological Models;Biology;Blindness;BODIPY;Bruch's basal membrane structure;career;Cholesterol;Clinical;Complement;Complex;Data;Deposition;design;Developed Countries;Development;Diet;Diffuse;Disaccharides;Disease;Drusen;Dryness;Elderly;Electron Microscopy;Enzymes;Equilibrium;Event;experimental study;Extracellular Matrix;Genetic Polymorphism;Genetic study;Glycobiology;Glycosaminoglycans;Goals;Growth Factor;Health;Heparitin Sulfate;Heparitin sulfotransferase;histological studies;Human;Immunofluorescence Immunologic;Impairment;in vivo;Individual;intravenous injection;Kinetics;Label;Lipoprotein Binding;Lipoproteins;Low-Density Lipoproteins;macromolecule;macula;Mentors;Metabolism;Modification;Mus;Names;Nature;Nonexudative age-related macular degeneration;novel therapeutics;Pathway interactions;Patients;Pattern;pharmacologic;Physicians;Proteins;Proteoglycan;Quartz;Retina;Risk;Risk Factors;Role;Scientist;Side;skills;Smoking Status;Structure;Structure of retinal pigment epithelium;Sulfate;Testing;therapeutic target;Training;Training Programs;Transgenic Mice;Variant;Visual impairment

PROJECT_TITLE: Role of Bruch Membrane Heparan Sulfate in Drusenogenesis in Age-Related Macular Degeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (04)]


NIH_SPENDING_CATS: Clinical Research;Genetics;Hematology;Human Genome;Patient Safety;Precision Medicine;Women's Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Variability in individual oral anticoagulant (OAC) response can result in reduced efficacy (thrombosis) and safety (hemorrhage), with anticoagulant-related hemorrhage the target of a national action plan. Limited diversity, evaluating only a small set of candidate genes, and lack of sex-specific analyses in current evidence, is a major barrier to establishing therapeutic drug/biomarker levels, personalizing, and optimizing OAC treatment. Identification of pharmacogenomic and metabolomic predictors of OAC drug/therapeutic target levels and clinical outcomes (hemorrhage), can improve our understanding of biologic pathways underlying altered OAC response, allow for the identification/establishment of new therapeutic targets and biomarkers, and be leveraged to develop personalized OAC strategies.

PI_NAMEs: DAVIS, BRITTNEY H (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Address;adverse drug reaction;Adverse effects;Affect;African;African American population;African American Women;African Women;Alabama;Anticoagulant therapy;Anticoagulants;Anticoagulation;Area;Asian;Atrial Fibrillation;Bioinformatics;Biological;Biological Markers;Blood;Blood Coagulation Factor;Blood Platelets;Candidate Disease Gene;career;career development;Clinical;Clinical Research;clinically significant;cohort;Computerized Medical Record;Conjugated Estrogens;CYP3A4 gene;Data;Development;Doctor of Pharmacy;Dose;Drug Combinations;Drug Kinetics;drug metabolism;Drug Prescriptions;Electronic Medical Records and Genomics Network;Enrollment;Enzymes;European;Evaluation;Exhibits;experience;Foundations;Frequencies;Gene Expression;Gene Frequency;Genes;Genetic;Glucuronates;Glucuronic Acids;Goals;Hemorrhage;Hospitalization;Hour;improved;Individual;individual variation;Knowledge;Linear Regressions;Liver;Logistic Regressions;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;metabolomics;mortality;mortality risk;multidisciplinary;new therapeutic target;novel marker;Oral;Outcome;Pathway Analysis;Pathway interactions;Patients;personalized medicine;personalized strategies;Pharmaceutical Preparations;Pharmacodynamics;pharmacogenetic variants;Pharmacogenetics;Pharmacogenomics;pharmacokinetics and pharmacodynamics;Phase;Phenotype;Prevalence;prevent;Quantitative Trait Loci;Research;response;response biomarker;Safety;Science;Scientist;sex;Sex Bias;Sex Differences;Signal Transduction;Site;skills;Sodium Chloride;Stroke;stroke risk;Therapeutic;therapeutic biomarker;therapeutic target;Thromboembolism;Thrombosis;Training;treatment response;treatment strategy;United States National Institutes of Health;Universities;Variant;Warfarin;Woman;Women's mortality;women's treatment;Work

PROJECT_TITLE: Ancestry and sex-related pharmacogenomic and metabolomic signatures of oral anticoagulant response

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (JA)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: PROJECT NARRATIVE This project will develop, optimize and evaluate a deep learning (DL) framework for accurate, reliable, and interpretable individualized treatment effect (ITE) inference, and can be widely generalizable to benefit aboard population that suffers from treatment selection. The proposed technique explores modeling the causal relations among multimodal status depiction, multi-treatment, and ITE in an end-to-end fashion by leveraging the novel DL technology, which is incapable of the current direct models for pre-operative prognosis, e.g., glioblastoma survival inference. Successful completion of the project will provide a clinically applicable DL technique for advising best interventions and improving treatment-specific pathology patterns investigation.

PI_NAMEs: LIU, XIAOFENG  (contact)

PROGRAM_OFFICER_NAME: PEREIRA DE SA, RUI CARLOS

PROJECT_TERMS: 3-Dimensional;Address;alternative treatment;base;Black Box;Calibration;Clinical;clinical application;Clinical Data;clinical implementation;Combined Modality Therapy;Data;Data Set;deep learning;deep learning algorithm;deep learning model;Demographic Factors;Diagnostic;Excision;experience;Glioblastoma;Goals;improved;individualized medicine;Intervention;Investigation;Label;Learning;learning network;Magnetic Resonance Imaging;Maps;Medical;Medical Records;Methods;Modality;model generalizability;Modeling;Multimodal Imaging;multimodality;neglect;novel;Outcome;outcome prediction;Pathology;Patient imaging;Patients;Pattern;Play;Population;Prognosis;radiomics;Retrospective Studies;Role;Scheme;Selection Bias;Selection for Treatments;Self Perception;self-attention;Techniques;Technology;Testing;Time;Training;treatment effect;treatment planning;Triplet Multiple Birth;Uncertainty;Visual;Visualization;Visualization software

PROJECT_TITLE: Deep Learning for Individualized Treatment Effect Inference with Multimodal Depiction

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Mental Health;Pediatric;Prevention

PHR: Project Narrative Caregivers between the ages of 18 and 30 are known as the “hidden” generation of caregivers – they makeup 43% of all U.S. caregivers and yet are largely absent from caregiving scholarship and supports. Due to their age and developmental stage, emerging and young adults who provide care to a parent with cancer are particularly vulnerable to developing psychological and behavioral problems as a result of their caregiving experience, and previous studies show they want guidance in navigating the interpersonal challenges that arise with their diagnosed parent and within their family during their parent’s cancer. Thus, the aim of this project is to fill this critical resource gap for emerging and young adult caregivers (EYACs) and adapt an existing caregiver communication support intervention to meet the age-specific needs of EYACs who care for a parent with cancer, improving their communication skills and reducing their risks of psychological distress.

PI_NAMEs: KASTRINOS, AMANDA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adult;Adult Children;Age;age difference;age group;age related;Anxiety;Area;Buffers;Cancer Intervention;Cancer Patient;career;Career Mobility;caregiver quality of life;Caregivers;caregiving;caregiving research;Caring;Centers for Disease Control and Prevention (U.S.);Child;Clinical;Communication;Communication difficulty;Competence;Complex;coping;Data;design;Development;Diagnosis;Distress;Educational Intervention;efficacy testing;emerging adult;emerging adulthood;Emotional;experience;Family;Family Planning;Fatigue;Feedback;Focus Groups;Future;Gatekeeping;Generations;Goals;Health;high risk;higher education;improved;Intervention;Interview;Label;Laws;Life Cycle Stages;life span;Link;Longitudinal Surveys;Malignant Neoplasms;Maps;Mental Depression;Mental Health;Mentors;Methods;older adult;Outcome;Parents;Patient Care Team;Patients;Pattern;Phase;physical conditioning;pilot test;pilot trial;Play Therapy;Population;Problem behavior;programs;psychologic;psychological distress;psychosocial;Randomized, Controlled Trials;Research;Research Personnel;Resources;Risk;Role;Scholarship;Scientist;secondary outcome;skill acquisition;skills;skills training;social;Surveys;Testing;Therapeutic;therapy development;Time;Training;Uncertainty;United States;virtual delivery;Well in self;Work;young adult

PROJECT_TITLE: Developing a communication support intervention for cancer caregivers in emerging and young adulthood


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Acute respiratory distress syndrome (ARDS) underlies many COVID-19 fatalities and is linked to uncontrolled production of inflammatory mediators. The goal of this proposal is to understand how lung damage from SARS- CoV-2 infection, the virus that causes COVID-19, promotes this harmful inflammatory response and to identify specific molecules that mediate this response. Mechanistic insight from this work will inform therapeutic design and has broader relevance to all viral pathogens that cause ARDS.

PI_NAMEs: BARNETT, KATHERINE CAMILLE (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Acute Lung Injury;Acute Respiratory Distress Syndrome;Adaptor Signaling Protein;Advisory Committees;airway epithelium;anakinra;biomarker identification;Body Weight;Bystander Effect;CASP1 gene;Cell Communication;Cell Culture Techniques;Cell Death;Cell Death Induction;Cell secretion;cell type;Cells;Clinical Trials;Coculture Techniques;Collaborations;Communities;COVID-19;COVID-19 mortality;COVID-19 patient;COVID-19 test;CRISPR/Cas technology;Cues;cytokine;cytokine release syndrome;Data;design;Disease;DNA;env Gene Products;Epithelial Cells;Epithelium;Exogenous Factors;Faculty;Gene Deletion;Genes;Goals;Health;Hemorrhage;Human;Immune;In Vitro;in vivo;in vivo evaluation;Infection;Infection Control;Inflammasome;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Innate Immune Response;insight;Interleukin 6 Receptor;Interleukin-1;Interleukin-1 beta;Interleukin-6;Leukocytes;Ligands;Link;Lung;lung injury;Lytic;Mediating;member;Meta-Analysis;Modeling;Molecular;Molecular Biology;Molecular Target;mouse model;multiple omics;Mus;Myelogenous;Myeloid Cells;Names;Outcome;pathogen;pathogenic virus;Pathologic;Pathway interactions;Patient-Focused Outcomes;Patients;Pattern;Pattern recognition receptor;Phosphorylation;Phosphotransferases;post SARS-CoV-2 infection;Post-Translational Protein Processing;Production;programs;protein complex;Proteins;receptor;Receptor Signaling;Regulation;Research;Research Personnel;response;Role;Sampling;SARS-CoV-2 antibody;SARS-CoV-2 infection;SARS-CoV-2 variant;Severe Acute Respiratory Syndrome;severe COVID-19;Severities;Signal Transduction;single-cell RNA sequencing;skills;Source;Stimulus;success;System;Testing;Therapeutic;therapeutic target;Tissues;TNF gene;Toll-like receptors;Universities;Virion;Virus;Virus Diseases;Vision;Work

PROJECT_TITLE: Regulation of Pathologic Inflammasome Responses to SARS-CoV-2

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Allogeneic hematopoietic stem cell transplant (HCT) remains the only curative therapy for many aggressive malignancies and is increasingly used for non-malignant disorders, but successful outcomes are limited by graft- vs-host-disease (GVHD) and inadequate graft-vs-tumor (GVT) activity. De novo DNA methylation catalyzed by DNMT3a is a major epigenetic mechanism that controls the post-HCT immune response. This project will define the DNMT3a-dependent pathways that can be targeted in the regulation and separation of harmful GVHD from beneficial GVT activity, which remains a critical unmet need toward improving patient outcomes.

PI_NAMEs: KTENA, YIOULI  (contact)

PROGRAM_OFFICER_NAME: WELNIAK, LISBETH A

PROJECT_TERMS: Acceleration;Acute Graft Versus Host Disease;Alloantigen;Allogenic;Apoptosis;Area;Bioconductor;Bioinformatics;Biological Assay;Biometry;bisulfite sequencing;career;CCR9 gene;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Lineage;cell motility;Cell Separation;Cells;chemokine receptor;Classification;Clinical;clinically relevant;comparative;Critical Pathways;curative treatments;Data;Data Analyses;design;Disease;disorder control;DNA Methylation;DNA Modification Methylases;DNMT3a;DNMT3a mutation;Down-Regulation;Epigenetic Process;epigenome;exhaustion;Exhibits;experience;Experimental Neoplasms;Flow Cytometry;Funding;Future;Gastrointestinal tract structure;Gene Expression;Gene Expression Profile;Genes;Goals;graft versus host disease induction;graft vs host disease;Graft vs Tumor Effect;Graft-Versus-Tumor Induction;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Homing;Human;Immune;Immune response;Immune Tolerance;Immunity;immunoregulation;Immunotherapeutic agent;improved;in vivo;Infection;Intestines;Knock-out;knockout animal;Laboratories;leukemia;Malignant - descriptor;Malignant Neoplasms;Mediating;Methodology;Methods;Methylation;methylome;Modeling;Modification;mouse model;Mus;Mutate;Myelogenous;Myeloid Cells;neoantigens;Non-Malignant;novel;novel strategies;novel therapeutic intervention;Organ;Outcome;Participant;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Physicians;Play;pre-clinical;prevent;Regulation;Relapse;relapse risk;Research;Research Design;Research Methodology;Risk;Role;Scientist;Severity of illness;Signal Transduction;skills;success;T cell regulation;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;Testing;Therapeutic;trafficking;Training;transcriptome;transcriptome sequencing;transcriptomics;translational potential;Translational Research;transplant model;Transplant Recipients;Transplantation Tolerance;tumor;Tumor Immunity;whole genome;Work

PROJECT_TITLE: Donor DNMT3a-mediated regulation of Graft-vs-Host-Disease and the Graft-vs-Tumor effect in allogeneic hematopoietic cell transplantation

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (JA)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative A significant number of older adults are aging alone, which puts them at increased risk for developing Alzheimer’s disease and related dementias (ADRD) when compared to those older adults who are not aging alone. In order to reduce the likelihood for social isolation and cognitive decline among older adults who live alone while still promoting independent living, it is essential to develop innovative methods to promote social connection. This study proposes to test the feasibility and acceptability of a novel virtual reality (VR) intervention to promote social interaction and cognitive health among older adults who live alone.

PI_NAMEs: FRANCIS, JESSICA  (contact)

PROGRAM_OFFICER_NAME: PLUDE, DANA JEFFREY

PROJECT_TERMS: acceptability and feasibility;Address;Adult Children;Aging;Alzheimer's disease related dementia;Area;base;career;career development;Caregivers;Clinical;Cognition;Cognitive;cognitive neuroscience;community advisory board;community engagement;Counseling;Data;dementia risk;design;Educational Materials;Effectiveness;efficacy testing;Ensure;Environment;experience;Family;feasibility testing;Feeling;field study;Foundations;Future;Goals;Head;Health;Home;human old age (65+);Immersion;Impaired cognition;implementation intervention;improved;Incidence;Independent Living;Individual;Industry;informal caregiver;innovation;insight;Intervention;Intervention Studies;Interview;K-Series Research Career Programs;Life Expectancy;Loneliness;Measures;member;Memory;Mentors;Method Acceptability;Methods;Michigan;Modeling;neurocognitive disorder;novel;Observational Study;older adult;Outcome;Participant;Pathway interactions;Perception;Personal Satisfaction;preventive intervention;programs;Protocols documentation;recruit;Reporting;Research;Research Personnel;Research Support;Resources;Risk;risk mitigation;Risk Reduction;satisfaction;Secure;Series;social;social engagement;Social Interaction;Social isolation;Social Network;social relationships;social science research;Social Sciences;Structure;Target Populations;Technology;technology intervention;Testing;Time;Training;United States;United States National Institutes of Health;University resources;usability;Validity and Reliability;virtual;virtual assessment;virtual reality intervention;Visit;Visual attention;Vulnerable Populations;Work

PROJECT_TITLE: Virtual Convoys: A Social VR Approach to Reducing ADRD risk among Older Adults Living Alone (NIA)

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Dissemination and Implementation Research;Maternal Health;Mental Health;Pediatric;Prevention;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Evidence-based interventions have great potential to improve public health, but many are not sustained over time. This project will first examine how existing implementation strategies prepare home visiting programs to sustain an evidence-based postpartum depression prevention intervention, and will subsequently develop a refined set of strategies that will be pilot tested. In developing a refined sustainability strategy, this project has the potential to improve the mental health of pregnant and parenting individuals and to provide guidance to other researchers looking to sustain evidence-based interventions in home visiting programs.

PI_NAMEs: TANDON, SHIV DARIUS (contact)

PROGRAM_OFFICER_NAME: LUSHIN, VICTOR

PROJECT_TERMS: Address;Adoption;Affect;Area;Assessment tool;Birth;Caring;Child;Child Abuse and Neglect;Child Rearing;Client;Clinical;cognitive development;cohort;Communities;Complication;contextual factors;Data;District of Columbia;effective intervention;Effectiveness;evidence base;Evidence based intervention;Evidence based practice;Funding;Goals;Health;Home visitation;human centered design;Hybrids;Impairment;implementation evaluation;implementation fidelity;implementation intervention;implementation research;implementation science;implementation strategy;improved;Individual;Infant Mortality;innovation;Interpersonal Relations;intervention delivery;Interview;Language Development;Maternal and Child Health;Measures;medical specialties;Mental Health;Methods;Modeling;Mothers;National Institute of Mental Health;New Mexico;Outcome;peripartum depression;Phase;pilot test;Positioning Attribute;Postpartum Depression;Practical Robust Implementation and Sustainability Model;Pregnancy;pregnant;prevent;Prevention;preventive intervention;Primary Care;Privatization;Program Sustainability;programs;Provider;Public Health;Readiness;Recommendation;recurrent depression;Reporting;Research;Research Personnel;Rhode Island;Role;scale up;Schools;Self Efficacy;Services;Structure;success;Surveys;Testing;Time;Training;United States Preventative Services Task Force;Woman;Work

PROJECT_TITLE: Examining the role of implementation strategies in sustaining evidence-based interventions in home visiting

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Microbiome;Prevention;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Laboratory mice are a critical research tool for testing vaccines, drugs, and other interventions prior to human clinical trials, but recent work has shown that because these mice are maintained in such well-controlled environments, they fail to mimic human immune responses. Exposure of mice to a brief series of natural viral infections helps mature their immune systems to better represent adult humans, and is an approachable method for researchers to quickly and easily make their studies more human-relevant. Further refinement of the infection regimen and study of the role for already-present microbes in these mice will yield an even simpler approach as well as better understanding of the specific exposures important to mimic human immunity.

PI_NAMEs: BALDRIDGE, MEGAN T (contact)

PROGRAM_OFFICER_NAME: KELLY, HALONNA R

PROJECT_TERMS: Adenoviruses;Adult;Age;animal facility;Antibiotic Therapy;Antibodies;Antibody Response;Astrovirus;bacteriome;Beds;Biological Assay;Cells;Clinical Trials;Communicable Diseases;Communities;Containment;Controlled Environment;cost;COVID-19 vaccination;COVID-19 vaccine;cytokine;Data;Development;Disadvantaged;Enteral;Enterovirus;Environment;Exhibits;experience;experimental study;Exposure to;fecal transplantation;fetal;Germ-Free;Goals;granulocyte;Helminths;Herpesviridae;Housing;Human;human model;Immune;immune activation;Immune response;Immune system;Immunity;Immunologic Stimulation;Immunological Models;Immunophenotyping;in vivo;Individual;Infection;Inflammatory;influenzavirus;insight;Intervention;Intestines;Intramuscular;Laboratory mice;Life;Lymphocyte;Methods;Microbe;microbial;microbial community;microbiome;microbiota;microbiota composition;Modeling;mouse model;mucosal vaccination;mucosal vaccine;Mucous Membrane;Mus;mycobiome;neonatal mice;Norovirus;novel;Outcome;pathogen;pathogen exposure;pathogenic virus;Pharmaceutical Preparations;Phenotype;Predictive Value;preservation;Protocols documentation;Publishing;Recording of previous events;Regimen;Research;Research Personnel;response;Risk;Role;Rotavirus;Series;Serum;Testing;tool;Vaccination;vaccine evaluation;vaccine response;Viral;virome;Virus Diseases;Weaning;Work

PROJECT_TITLE: Compressed sequential infection regimen to model immune responses to systemic and mucosal vaccination

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

PHR: NARRATIVE It is a national priority to combat maternal health inequities, which disproportionately affect individuals from Black, Indigenous, and other minoritized communities. Hospitals are well- positioned to advance birth equity, but there is inadequate evidence to guide their intervention efforts. The proposed research will use in-depth interdisciplinary methods and guidance from affected communities to generate new insights about how hospitals are working to advance maternal health equity, about the factors helping or hindering their efforts, and about ways to align this work with their communities’ priorities.

PI_NAMEs: GARRETT, SARAH BRACEY (contact)

PROGRAM_OFFICER_NAME: OLADEINDE, YEWANDE A

PROJECT_TERMS: Accountability;Adoption;Advisory Committees;Affect;anti-racism;Area;Award;Birth;Black Populations;Black race;black women;California;career;Caring;Case Study;Clinical;cohort;combat;Communities;community engagement;community partners;comparative;Country;Data;design;Disparity;Doctor of Philosophy;Educational process of instructing;Environment;Equity;ethnic disparity;Evaluation;experience;Focus Groups;Foundations;Funding;Future;Goals;Health care facility;health equity;health equity promotion;Health equity research;health inequalities;Health Policy;Health system;Healthcare;Healthcare Systems;Hospitals;implementation outcomes;implementation science;improved;Incentives;Income;Indigenous;indigenous community;Individual;Inequity;informant;insight;Institution;Institutional Policy;Intervention;Interview;K-Series Research Career Programs;Knowledge;Law Enforcement;Lived experience;Maintenance;maltreatment;Maternal Health;Maternal health equity;Maternal Health Services;Maternal Mortality;Measures;Medical;Medicine;meetings;member;Mentors;Mentorship;Methods;minority communities;minority engagement;Minority Groups;National Institute on Minority Health and Health Disparities;next generation;Not Hispanic or Latino;Organizational Change;Outcome;Participant;Patient Care;Patient-Focused Outcomes;Patients;Perinatal;Positioning Attribute;Pregnancy;professor;programs;Prospective Studies;Provider;Qualitative Research;Quality of Care;Race;Reporting;Reproductive Health;Research;Research Design;Research Methodology;Research Personnel;response;Risk;Role;safety net;San Francisco;Science;Scientist;Services;severe maternal morbidity;Shapes;Site;skills;Social Sciences;socioeconomics;sociologist;Statutes and Laws;Structural Racism;theories;Training;Universities;White Women;Work

PROJECT_TITLE: Maternal health interventions in California hospitals: Understanding approaches & implementation to advance equity

STUDY_SECTION_NAME: Special Emphasis Panel[ZMD1 DRI (J1)]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Patient Safety

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE The proposed research aims to assess and refine an electronic patient-reported outcomes (PROs) tool, “Goals to Discharge” (G2D), for surgical oncology patients focused on discharge planning to augment currently established discharge pathways. The project will refine actionable PROs items, optimize the tool using implementation science strategies, and test its effectiveness for improving patients' readiness for hospital discharge. Results will lead to better quality of care, better informed patients, and better outcomes, including length of stay and readmission rates for surgical oncology patients.

PI_NAMEs: CRACCHIOLO, JENNIFER R (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adoption;cancer care;cancer surgery;career;career development;Caregivers;Caring;Clinical;clinical care;clinical decision support;Clinical Trials;Cluster randomized trial;Colectomy;Colorectal Surgery;Communication;Consultations;Data;Development;Development Plans;digital tool;Discharge Plannings;Disease;Doctor of Philosophy;Effectiveness;effectiveness testing;electronic patient reported outcomes;empowerment;Ensure;Evaluation;expectation;Goals;Gynecologic Surgical Procedures;Home;hospital readmission;Hospitalization;Hospitals;implementation science;implementation strategy;improved;Infrastructure;Inpatients;Intervention;Interview;Knowledge;Length of Stay;Libraries;Malignant Neoplasms;Maps;Measurement;Measures;member;Memorial Sloan-Kettering Cancer Center;Mentors;Methods;Multicenter Trials;multidisciplinary;novel;Oncology;Operative Surgical Procedures;Ostomy;Outcome;Pathway interactions;patient engagement;Patient Focused Care;patient navigation;patient oriented;Patient Outcomes Assessments;Patients;pilot test;preference;Preparation;prevent;primary outcome;Process;Qualitative Methods;Quality of Care;Questionnaires;Readiness;readmission rates;Research;Research Design;Research Personnel;response;secondary endpoint;secondary outcome;Site;Stomas;Structure;Surgical Oncology;System;Target Populations;Technology;technology validation;Testing;Thoracic Surgical Procedures;Time;tool;Training;treatment as usual;trial design

PROJECT_TITLE: Integrating Electronic Patient-Reported Outcomes into Discharge Planning

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Hematology;Infectious Diseases;Kidney Disease;Rare Diseases;Sepsis

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Project Narrative This proposal will elucidate biochemical and physiologic evidence that tissue kallikrein regulates responses of innate immunity to Shiga toxin E. coli Hemolytic Uremic Syndrome (STEC-HUS). We will investigate the role of tissue kallikrein in mediating alternative complement pathway dysregulation in STEC-HUS using cellular and animal models of disease. The proposed work will lay the foundation for future studies in which the mechanisms of alternative complement pathway activation are more broadly examined in HUS and other infectious and immunologic diseases that are characterized by complement overactivation.

PI_NAMEs: SARTAIN, SARAH ELIZABETH (contact);YEE, ANDREW

PROGRAM_OFFICER_NAME: BAQAR, SHAHIDA

PROJECT_TERMS: 2019-nCoV;Acceleration;activation product;Acute Renal Failure with Renal Papillary Necrosis;Adult;Alternative Complement Pathway;Animal Disease Models;Animal Model;Area;Binding;Biochemical;biochemical model;Biological Process;Biology;Blood Vessels;Candida albicans;cell injury;Cell model;Cell surface;Child;Childhood;Chronic;cleavage factor;Clinical;Communicable Diseases;Complement;Complement 3 Convertase;Complement 3a;Complement 3b;Complement Activation;Complement Factor B;Complement Factor D;Complement Factor H;complement pathway;Complex;Data;Deposition;Diarrhea;Disease;Elderly;End stage renal failure;Endothelium;Endotoxemia;Equilibrium;Escherichia coli;Escherichia coli EHEC;Etiology;Experimental Models;Fibrinogen;foodborne pathogen;Foreign Bodies;Foundations;Functional disorder;Future;glomerular endothelium;Hemolytic Anemia;Hemolytic-Uremic Syndrome;Hemorrhagic colitis;Heterodimerization;Immune response;Immune System Diseases;improved;Incidence;Infection;Inflammation;Inflammation Mediators;Inflammatory;Inflammatory Response;Influenza;Influenza A Virus, H1N1 Subtype;inhibitor;Injury;Injury to Kidney;Innate Immune System;Intervention;Kidney;Knockout Mice;Link;Lipopolysaccharides;Liquid substance;Measures;Mediating;Mediator;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Natural Immunity;novel;Organ failure;pathogen;Pathway interactions;Patients;Peptide Hydrolases;Phase;Physiological;Plasma Kallikrein;Play;prevent;protein purification;Proteolysis;Recombinants;Regulation;Research;Research Personnel;response;Role;Secondary to;Septic Toxemia;Serine Protease;SERPINA4 gene;Shiga Toxin;Site;Source;Streptococcus pneumoniae;Structure;System;Testing;Thrombocytopenia;thrombotic;Ticks;Tissue Kallikrein;Tissues;trend;Up-Regulation;Urinary Kallikrein;Work

PROJECT_TITLE: Role of tissue kallikrein in alternative complement pathway activation in STEC-HUS

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Fentanyl Misuse and Addiction;Lung;Neurosciences;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project aims to investigate the neural mechanisms of fentanyl-induced respiratory depression, specifically focusing on airway constriction and rhythmic disruptions. The project proposes the development of dual-action treatments that address these issues without reversing the opioid's effect, offering a new approach to combating opioid overdoses. Using a combination of cutting-edge techniques like in-vitro and in-vivo electrophysiology, optogenetics, high-density neuronal network analysis, and viral-based manipulation, we aspire to provide significant breakthroughs in our understanding and treatment of opioid-induced respiratory depression.

PI_NAMEs: BURGRAFF, NICHOLAS J (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Absence of pain sensation;Acute;Acute Pain;Address;Adverse effects;Advisory Committees;Agitation;Animals;Area;Autonomic nervous system;Binding;Bronchoconstriction;Bronchodilation;Bronchodilator Agents;career;career development;Cause of Death;Cell Nucleus;cholinergic;Combined Modality Therapy;Complement;constriction;Data;Dedications;density;Development;dorsal motor nucleus;Drug Modulation;effective therapy;efficacy evaluation;Electrophysiology (science);Equilibrium;experience;Fatal Outcome;Fentanyl;Funding;Generations;Goals;Grant;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor;Institution;Intervention;Investigation;K-Series Research Career Programs;Knowledge;Life;Light;Maps;Mediating;Medical;Mentorship;Methodology;Muscle Tonus;Naloxone;nerve supply;neural;neural circuit;neural network;neuromechanism;neuronal circuitry;Neurons;neurophysiology;novel strategies;novel therapeutics;nucleus ambiguus;Operative Surgical Procedures;Opioid;Opioid Antagonist;opioid epidemic;opioid overdose;Opioid Receptor;opioid therapy;opioid use;optogenetics;Overdose;patch clamp;Pathway Analysis;patient safety;Patient-Focused Outcomes;Periodicity;Pharmaceutical Preparations;Pharmacologic Substance;Physicians;Physiology;Play;Positioning Attribute;professor;programs;Public Health;Regulation;Research;research and development;Respiration;respiratory;Respiratory physiology;respiratory smooth muscle;response;Risk;Role;Severities;Site;Smooth Muscle;success;synthetic opioid;System;Techniques;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;Training;treatment strategy;United States;Ventilatory Depression;Veratridine;Viral;Withdrawal;Work of Breathing

PROJECT_TITLE: Unraveling the Mechanisms of Opioid-Induced Airway Constriction: A Path towards Novel Therapeutics for Opioid Overdose

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI (JA)]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_STATE: MI

PHR: Project Narrative Although the human disease-causing parasite Toxoplasma gondii is known to exploit a host membrane remodeling system (ESCRT) to acquire nutrients for its growth during infection, precisely how this parasite hijacks the ESCRT system remains poorly understood. The proposed research will identify new ways that T. gondii exploits host ESCRT and it will determine how new components of the parasite function together to support parasite growth that is essential for disease.

PI_NAMEs: CARRUTHERS, VERNON BRUCE (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acute;Binding;Biology;Bipolar Disorder;Blindness;Cell division;Cell Physiology;Cells;Collaborations;Complex;congenital infection;Coupled;CRISPR screen;CRISPR/Cas technology;Cytoplasm;Cytosol;defined contribution;digital;Disease;Endosomes;Ensure;Environment;Fetal Development;Genetic Screening;Goals;Growth;Health;HIV;Human;human disease;human pathogen;Hypothetical Protein;Image;Image Analysis;Immune Evasion;immunodeficiency;Individual;Infection;Ingestion;insight;intercellular communication;Knowledge;Link;link protein;Lipids;Machine Learning;Maintenance;Malignant Neoplasms;Mediating;Membrane;Mental disorders;Multivesicular Body;Mus;Natural Immunity;Nervous System Trauma;novel;Nuclear Envelope;Nutrient;obligate intracellular parasite;Organ;Organ Transplantation;Organelles;Parasites;Phenotype;Phosphorylation;Phosphotransferases;Play;Populations at Risk;prospective;protein complex;protein degradation;Proteins;rapid growth;recruit;Reporting;Research;Residual state;Resources;Risk Factors;Role;Schizophrenia;secretory protein;Series;Sorting;Structure;System;Testing;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;TSG101 gene;Vacuole;Vertebrates;Vesicle;virtual;Virulence Factors;Work

PROJECT_TITLE: Defining a novel protein network for Toxoplasma repurposing of host ESCRT machinery

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Autism;Autoimmune Disease;Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Coronaviruses;Coronaviruses Therapeutics and Interventions;Dementia;Emerging Infectious Diseases;Genetics;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Mental Health;Multiple Sclerosis;Neurodegenerative;Neurosciences;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: General Audience Summary This preclinical study will test the effectiveness of a new drug class to limit SARS-CoV-2 neuroinflammation that is associated with COVID-19 neurological complications. The results may have broader applications to treat other conditions involving CNS inflammation.

PI_NAMEs: KAUFMAN, DANIEL  (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: 2019-nCoV;A/J Mouse;ACE2;Acute;Adipose tissue;Affect;Agonist;Alzheimer's disease patient;Anti-Inflammatory Agents;Antigen-Presenting Cells;Anxiety;Astrocytes;autism spectrum disorder;autoreactive T cell;behavior test;Behavioral;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier crossing;Brain;brain fog;Brain region;Cells;Cessation of life;chemokine;clinical application;Clinical Trials;Community Health;Consumption;Coronavirus;Coronavirus Infections;COVID-19;COVID-19 patient;COVID-19 treatment;cytokine;Dendritic Cells;Development;Diabetic mouse;Disease;early phase clinical trial;Early treatment;Edema;effectiveness testing;Experimental Autoimmune Encephalomyelitis;Frequencies;GABA Receptor;GABA-A Receptor;gamma-Aminobutyric Acid;Gene Expression;Gene Expression Profiling;global health;Goals;Hamsters;histological studies;homotaurine;Human;Immune;immune cell infiltrate;Immune response;Immunohistochemistry;Immunosuppressive Agents;Impaired cognition;improved;Infection;Inflammation;Inflammatory;Insulin-Dependent Diabetes Mellitus;K-18 conjugate;Learning;Long COVID;Lung;Macrophage;Medical Research;Mental Depression;Mesocricetus auratus;Metformin;Microglia;model of autism spectrum disorder;Modeling;Morbidity - disease rate;mortality;mouse model;Multiple Sclerosis;Mus;Nervous System Disorder;Neuroglia;neuroinflammation;Neurologic;neurologic sequelae of COVID-19;neuron loss;novel coronavirus;novel drug class;novel strategies;novel therapeutic intervention;Oral;Outcome;Patients;Paxlovid;Pharmaceutical Preparations;Phenotype;Population;post SARS-CoV-2 infection;Pre-Clinical Model;preclinical study;prevent;Property;prophylactic;Proteins;Receptor Inhibition;Research Personnel;Resistance development;response;Rheumatoid Arthritis;Risk Reduction;Rodent Model;SARS-CoV-2 infection;SARS-CoV-2 variant;Serum;Severities;Severity of illness;Steroids;systemic inflammatory response;T cell response;T-Lymphocyte;Testing;Therapeutic;Therapeutic Effect;Time;Toxic effect;transcription factor;Transgenic Mice;Type 2 diabetic;Viral Load result;Virus Replication

PROJECT_TITLE: Therapy for long-COVID in a preclinical model

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Chronic Pain;Clinical Research;Networking and Information Technology R&D (NITRD);Pain Research;Pediatric;Prevention;Sleep Research;Substance Misuse;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Pediatric chronic pain is a common, complex and highly debilitating developmental health concern that has been associated with multiple risk factors for heavy and frequent marijuana use. However, the longitudinal interplay among chronic pain and two key risk factors, sleep disturbances and decreased inhibitory control, as it relates to adolescent marijuana use, remains minimally explored. This study aims to map the unfolding of pathophysiological processes using a combination of mobile health assessment tools, in order to implement personalized, early intervention in these vulnerable adolescents.

PI_NAMEs: KOSSOWSKY, JOE  (contact)

PROGRAM_OFFICER_NAME: VIDAL, SARAH

PROJECT_TERMS: Adolescent;adolescent health;Adolescent marijuana use;adolescent substance use;Assessment tool;career;Cellular Phone;Childhood;chronic pain;circadian biology;cognitive testing;Collection;Complex;Data;Development;Dimensions;Early Intervention;Ecological momentary assessment;Event;Frequencies;Goals;Grant;Health;Individual;Interruption;Intervention;K-Series Research Career Programs;Life;Maps;Marijuana;marijuana use;marijuana use disorder;Measurement;Mentored Research Scientist Development Award;Mentors;Methods;mHealth;mobile application;Mobile Health Application;Modeling;Outcome;Pain;Patients;Polysomnography;Population;Process;Protocols documentation;Randomized, Controlled Trials;Research;Research Personnel;Research Project Grants;responsible research conduct;Risk;Risk Factors;Risk Reduction;Sampling;Sleep;Sleep disturbances;substance use;Techniques;Technology;Time;Training;vulnerable adolescent;wearable device;Youth

PROJECT_TITLE: Mobile health applications in adolescent marijuana use: assessing the interplay among sleep, pain and inhibitory control - Supplement

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]