NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Genetics;Interstitial Cystitis;Mental Health;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: BIRMINGHAM

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE The prevalence of urologic chronic pelvic pain syndrome (UCPPS) in the United States is high, ranging from 14- 25% of men and women. The pathology of UCPPS is multifactorial and existing therapies are both limited and unsatisfactory, underscoring the need for preclinical models that are reflective of disease complexity to advance our mechanistic understanding and identify new treatment strategies. To achieve these goals, we propose to systematically phenotype a dual-insult, preclinical model with high relevance to the clinical condition in order to examine promising targetable units that individually or in combination alter the peripheral nervous system and lead to UCPPS.

PI_NAMEs: DEBERRY, JENNIFER J (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: acute stress;Address;Adult;Adverse event;afferent nerve;Afferent Neurons;Anatomy;Animal Model;Animals;Behavior;Biological Response Modifiers;Bladder;Chronic;chronic pelvic pain;Chronic Prostatitis;Chronic stress;Clinical;Clinical Data;clinically relevant;CNS processing;Complex;Coupled;Development;Disease;disease model;dorsal horn;early experience;Electrophysiology (science);Emotional;epidemiologic data;Esthesia;Event;experience;Exposure to;extracellular;Future;Genetic;Genitourinary system;Goals;Histologic;human model;Hypersensitivity;improved;In Vitro;in vivo;Individual;Inflammation;information gathering;innovation;insight;Interstitial Cystitis;Knowledge;Lead;Life;Maintenance;maternal separation;Measures;Mediator;men;Modeling;mouse genetics;Musculoskeletal;Neonatal;neural;Neuroanatomy;neurochemistry;Neurons;Neuropeptides;neurophysiology;Nociception;novel;novel therapeutic intervention;Opioid;Optics;optogenetics;Organ;Pain;patch clamp;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient oriented;Patient-Focused Outcomes;Pelvic floor structure;Pelvic Pain;Pelvis;Peripheral;Peripheral Nerves;Peripheral Nervous System;Persons;Phenotype;physical insult;Population;Posterior Horn Cells;postnatal development;pre-clinical;Pre-Clinical Model;Predisposition;Prevalence;Process;Property;receptor;Reflex action;response;Rodent Model;Sensory;sensory system;Spinal;Spinal Cord;Stress;Stressful Event;Structure;Study models;Subgroup;System;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutically effective;Tissues;Transducers;Trauma;treatment strategy;United States;Urodynamics;urologic;urologic chronic pelvic pain syndrome;Visceral;Woman

PROJECT_TITLE: Preclinical phenotypic modeling of chronic urologic pelvic pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Biotechnology;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_FIPS: US

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative ! Stem cells sustain our tissues and organs, yet they are subject to age-related loss or dysfunction. Our studies address the molecular and cellular basis for the effects of aging on stem cell maintenance, and they will inform similar processes in humans with broad implications for degenerative diseases, cancer, stem cell biology, and regenerative medicine. !

PI_NAMEs: HUBBARD, E. JANE ALBERT (contact)

PROGRAM_OFFICER_NAME: COGLIATI, TIZIANA PAOLA

PROJECT_TERMS: Address;Affect;Age;age effect;age related;age related changes;age related decline;age-related disease;aged;Aging;aging mechanism;aging reversal;Anatomy;Automobile Driving;Biological;Biology of Aging;Caenorhabditis elegans;cell age;Cell Count;Cell Maintenance;cell replacement therapy;Cell Volumes;Cells;Defect;Degenerative Disorder;disability;Distal;Environment;Functional disorder;Genetic;genetic manipulation;Genetic Screening;Genetic Transcription;Germ Lines;germline stem cells;Gonadal structure;Hematopoietic;Hermaphroditism;Human;human stem cells;Image;in vivo;Insulin;insulin signaling;Knowledge;Ligands;Longevity;Malignant Neoplasms;Mediating;model organism;Modeling;Molecular;Molecular Genetics;Morphology;muscle progenitor cell;Natural regeneration;nerve stem cell;novel;Older Population;Organ;Output;Phenotype;prevent;Process;regenerative;Regenerative Medicine;Rejuvenation;Reporter;Reproduction;reproductive;reproductive senescence;RNA Interference;Role;Signal Transduction;Skin;stem;stem cell aging;stem cell biology;stem cell function;stem cell niche;stem cell replacement;stem cells;System;Testing;tissue degeneration;Tissues;transcriptome sequencing;Validation;Work

PROJECT_TITLE: The aging stem cell niche

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ADMINISTERING_IC: NS

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: PROJECT NARRATIVE Roughly 10% of the mammalian corticospinal tract terminates ipsilaterally and is known to be involved in motor recovery from unilateral hemispheric injury; however, its detailed anatomy and function are unknown. The guiding hypothesis of this project is that the ipsilateral corticospinal tract is involved in the coordination of bilateral motor behavior. This project uses a novel method combining single nucleus sequencing and monosynaptic viral tracing to map the connectivity of the iCST at single-neuron resolution, a molecular barcode-based approach to reconstruct its projection structure in detail, retrograde tracing and tissue clearance to map its topography, and chemogenetic tools to investigate its function in behavior.

PI_NAMEs: FAIT, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Address;Anatomy;Animals;Architecture;Atlases;Axon;Bar Codes;Behavior;Behavioral Genetics;Behavioral Paradigm;Bilateral;Biological Assay;Catalogs;cell type;Clinical;Clinical Trials;Compensation;Contralateral;Corticospinal Tracts;Data;Data Analyses;Data Set;Development;Ensure;examination questions;experience;experimental study;Fiber;Fluorescence;Genetic;genetic manipulation;hemisphere damage;improved;Individual;Injury;Interneurons;Ipsilateral;Lead;Learning;Limb structure;Link;Maps;Methods;Molecular;Motor;motor behavior;motor control;Motor Cortex;motor recovery;Movement;Movement Disorders;Multiplexed Analysis of Projections by Sequencing;Mus;mutant;Mutant Strains Mice;neural circuit;Neuroanatomy;Neurons;Neurosciences;nonhuman primate;novel;novel strategies;Pattern;Performance;Play;Population;Positioning Attribute;postsynaptic;Process;reconstruction;Recovery;rehabilitation strategy;Rehabilitation therapy;Research;Resolution;Rodent;Role;Sensory;Severities;Side;single nucleus RNA-sequencing;skills;Spinal;Spinal Cord;Stroke;Structure;System;Testing;Tissues;tool;Transcranial magnetic stimulation;transcriptomics;Viral;Work

PROJECT_TITLE: The Structure and Function of Ipsilateral Corticospinal Projections


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Preterm birth (PTB) rates are disproportionately higher among Black women than their White peers. Accurate measurement of women’s chronic stress exposures unique to each race/ethnicity could help illuminate the unclear mechanisms underlying the Black-White disparities in PTB. This project develops machine learning algorithms to compute women’s complex chronic stress exposures and then identify women at high PTB risk.

PI_NAMEs: KIM, SANGMI  (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: 37 weeks gestation;Adopted;Adverse effects;Algorithms;Area;Artificial Intelligence;Attention;Behavioral;Birth;Birth Rate;Black Box;Black race;black women;black/white disparity;career development;Child Health;Chronic;Chronic stress;Clinical;community setting;Complement;Complex;Computers;Data;Databases;deep neural network;Early Intervention;early screening;education cost;ethnic disparity;ethnic diversity;ethnic minority population;Ethnic Origin;experience;explainable artificial intelligence;explainable machine learning;Exposure to;Family;Female of child bearing age;Financial Hardship;Functional disorder;Goals;Grant;Health Promotion;Healthcare;High Prevalence;Hybrids;Incidence;Infant;Instruction;Knowledge acquisition;large scale data;Learning;Linear Regressions;Link;Literature;Logistic Regressions;Machine Learning;machine learning algorithm;machine learning model;Manuscripts;Maternal and Child Health;maternal risk;Measurement;Measures;Medical Care Costs;Methodology;Methods;Modeling;Monitor;multidimensional data;Nature;neural network algorithm;Not Hispanic or Latino;novel;Outcome;Patients;Pattern;peer;Population;Populations at Risk;Pregnancy;Pregnant Women;Premature Birth;Preparation;prevent;Public Health Informatics;Race;racial disparity;racial diversity;racial minority population;Research Design;Risk;Risk Assessment;Risk Factors;risk prediction;ROC Curve;Sampling;skills;Social outcome;sociodemographics;Statistical Models;Stress;stressor;Study models;System;Techniques;Testing;Time;tool;Training;Variant;Violence;White Women;Woman;Work

PROJECT_TITLE: Race/Ethnicity-Specific Algorithms of Chronic Stress Exposures for Preterm Birth Risk: Machine Learning Approach

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(82)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Chronic Pain;Genetics;Human Genome;Osteoarthritis;Pain Research;Physical Injury - Accidents and Adverse Effects

ORG_CITY: ANN ARBOR

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Post-traumatic osteoarthritis (PTOA) is a complex degenerative joint disease that arises after injury and is characterized by pain, cartilage degradation, synovial inflammation and fibrosis, and formation of ectopic bone growths called osteophytes. PTOA is a chronic, debilitating condition that affects millions worldwide, yet there are currently no disease-modifying treatments. The overarching objective of this proposal is to comprehensively characterize cells and processes responsible for PTOA progression and to provide insights for the development of effective PTOA treatments that will meaningfully and tangibly improve patient outcomes.

PI_NAMEs: KNIGHTS, ALEXANDER JOHN (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Actins;Affect;Agonist;Arthritis;arthropathies;articular cartilage;ATAC-seq;Automobile Driving;beta catenin;Binding;Bioinformatics;Biological Assay;Biology;bone;Bone Growth;Bone Spur;career;Cartilage;cartilage degradation;Cell Nucleus;Cell Surface Receptors;cell type;Cells;Characteristics;Chondrocytes;Chronic;Clinical Research;Complex;Coupled;cytokine;Data;Degenerative polyarthritis;Development;differentiation in vitro;Disease;effective therapy;Fibroblasts;Fibrosis;G-Protein-Coupled Receptors;Goals;Health;Human;Hypertrophy;Immune;improved;In Vitro;inducible Cre;Inflammation;Inflammatory;Injections;injured;Injury;insight;Interleukin-6;joint function;joint injury;Joints;Kinetics;Knee;Knockout Mice;Knowledge acquisition;Label;Leucine-Rich Repeat;Link;Long term disability;Macrophage;Macrophage Activation;Mediating;Mentorship;mineralization;Molecular;Molecular Biology;Molecular Immunology;Multimodal Imaging;multiple omics;Mus;Musculoskeletal;Myofibroblast;neutralizing antibody;novel;Osteoblasts;osteochondral tissue;Osteogenesis;osteogenic;Outcome;Pain;pain sensitivity;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patient-Focused Outcomes;pharmacologic;Phase;Population;Positioning Attribute;preclinical study;Process;progenitor;Proteins;Proteoglycan;receptor;Reporter;Reporter Genes;Research;Role;Science;Secondary to;Severities;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;skill acquisition;skills;Smooth Muscle;Synovial Cell;Synovial Fluid;Synovial Membrane;Synovitis;Technical Expertise;Testing;Tissues;Training;transcriptome sequencing;Transgenic Organisms;Traumatic Arthropathy;Vocational Guidance;Work

PROJECT_TITLE: Fibrosis, inflammation, and osteophyte formation in post-traumatic osteoarthritis

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: STANFORD

ORG_DEPT: PEDIATRICS

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative Evidence demonstrates that the risks of red blood cell transfusions outweigh benefits in many patients who are hospitalized in the pediatric ICU with increased risk of organ dysfunction, infection, delirium, and death. Guidelines have been developed to restrict transfusion in patients who are unlikely to benefit; however, these guidelines have not been consistently adopted into clinical practice. This pilot study will examine use of targeted efforts to improve implementation of the guidelines and will inform a future study that evaluates the impact of restrictive transfusion practices and implementation of the transfusion guidelines, with a goal of reducing unnecessary transfusions and improving patient outcomes in critically ill children.

PI_NAMEs: STEFFEN, KATHERINE MARIE (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Transfusion Recommendations Implemented in the PICU (TRIP)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Services;Immunization;Infectious Diseases;Patient Safety;Prevention;Social Determinants of Health;Vaccine Related

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE Robust evaluation of vaccine safety is central to public confidence in COVID-19 vaccination, a critical tool to combat the pandemic. In this proposal, we will develop new approaches to detect serious adverse events that can happen after vaccination, and we will apply these new approaches to existing data from a large health care system to evaluate COVID-19 vaccine safety. Our study will produce rigorous evidence about the safety of COVID-19 vaccines for policymakers, clinicians, and the public.

PI_NAMEs: XU, STANLEY  (contact)

PROGRAM_OFFICER_NAME: PLIMACK, MARY KATHERINE BRADFORD

PROJECT_TERMS: Address;adverse event risk;American;Area Under Curve;Blood coagulation;California;Caring;Case Series;Characteristics;Clinical;Clinical Trials;combat;COVID-19 vaccination;COVID-19 vaccine;COVID-19 vaccine evaluation;Data;Data Sources;Databases;design;Detection;Dose;Epidemiologist;Evaluation;experience;Family;fighting;Foundations;health care service organization;Healthcare;Healthcare Systems;Incidence;Individual;Length;Measures;member;Messenger RNA;Methodology;Methods;Modeling;Monitor;Nature;new technology;novel;novel strategies;pandemic disease;Patients;Pattern;Persons;Policy Maker;Population;Population Heterogeneity;Race;Recommendation;Reporting;Research;response;Risk;Safety;safety assessment;safety study;Schedule;Serious Adverse Event;Signal Transduction;socioeconomics;Specific qualifier value;Statistical Models;success;System;Time;tool;United States;Vaccinated;Vaccination;vaccine acceptance;vaccine distribution;vaccine evaluation;vaccine hesitancy;vaccine safety;Vaccinee;Vaccines

PROJECT_TITLE: A risk-varying and perturbed self-controlled case series design for assessing the safety of COVID-19 vaccines in a large health care system

STUDY_SECTION: BMRD

STUDY_SECTION_NAME: Biostatistical Methods and Research Design Study Section[BMRD]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Drug Abuse (NIDA only);Substance Misuse

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Drug abuse and addiction represent major health issues in the United States with a tremendous impact on health care, loss of work, and crime. This Training Program in Substance Use and Use Disorders at UC Irvine will provide trainees with an educational and research training program that will position upcoming scientists to address key scientific issues in the addiction field.

PI_NAMEs: WOOD, MARCELO ANDRES (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Disease;substance use;Training Programs


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Childhood Injury;Clinical Research;Comparative Effectiveness Research;Dissemination and Implementation Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: PROJECT NARRATIVE Exposure to repetitive head impacts in contact sports such as football is a rising public health concern due to the connection with brain disease later in life and changes in the brain after a single season. This F31 Independent Predoctoral Fellowship Award will investigate the effectiveness of a novel evidence-based intervention program to reduce head impact exposure and negative clinical outcomes in youth football, while assessing the acceptability and feasibility of the intervention and utility of the strategy used to implement the intervention program. Formal training and experiential learning will prepare the applicant to become a productive and independent research scientist with cross-disciplinary skills in injury biomechanics and public health.

PI_NAMEs: MARKS, MADISON EVELYN (contact)

PROGRAM_OFFICER_NAME: DIXON, CINNAMON ANNE

PROJECT_TERMS: acceptability and feasibility;Active Learning;Age;Award;Biomechanics;Biometry;Brain;Brain Concussion;Brain Diseases;Brain Injuries;Certification;Clinical;clinical outcome assessment;clinical outcome measures;Clinical Trials Design;cognitive change;college;Communities;community engaged approach;comparative;contact sports;Custom;Data;Data Collection;data management;Development;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness/implementation study;Elements;Enrollment;Environment;Evaluation;Evidence based intervention;experience;Exposure to;Fellowship;Frequencies;Funding;Future;Goals;head impact;high school;human subject;implementation process;implementation science;implementation strategy;improved;inferential statistics;Injury;injury prevention;insight;instrument;Intervention;intervention program;junior high school;Lead;Life;Manufactured football;Measures;meetings;Mentors;Mentorship;Methods;Minor;Monitor;motor symptom;Musculoskeletal Equilibrium;National Institute of Child Health and Human Development;Nerve Degeneration;Nervous System Physiology;Neurocognition;Neurocognitive;neurocognitive test;Neurologic Deficit;Neuropsychology;novel;oculomotor;Outcome;Parents;Pathology;Pilot Projects;Positioning Attribute;pre-doctoral;prevent;Prevention strategy;Process;Productivity;Public Health;rate of change;recruit;Research;Research Personnel;Safety;Scientist;Seasons;sensor;Severities;skills;Sports;Sports Medicine;Structure;success;Testing;Time;Training;Traumatic Brain Injury;vestibular system;Work;Youth;youth sports

PROJECT_TITLE: An Implementation-Effectiveness Study of an Evidence-Based Intervention to Improve Head Impact Safety in Youth Football

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F16-L(20)L]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: Narrative The current study continues to follow a cohort of youth who have been surveyed about their alcohol and other drug (AOD) use since age 11, by having them complete four additional annual surveys from age 25-28. Continuing this epidemiological work will move the field forward significantly by providing a unique opportunity to better understand choices young people make around AOD use as they transition into young adulthood.

PI_NAMEs: D'AMICO, ELIZABETH J. (contact)

PROGRAM_OFFICER_NAME: CASTLE, I-JEN

PROJECT_TERMS: Address;Adolescence;Adult;Advertising;Affect;Age;Age Factors;age group;alcohol and other drug;alcohol consequences;Alcohol consumption;alcohol research;alcohol use disorder;Alcohols;Area;Asian;Asian population;Black race;California;Cannabis;career;Characteristics;Child Rearing;cohort;college;Data;Databases;density;Development;Disease;Disparity;driving under influence;Drug usage;Economics;Education;emerging adulthood;Employment;Environment;Environmental Risk Factor;Epidemiology;ethnic disparity;ethnic diversity;Ethnic Origin;Exposure to;Face;Family;Female;functional independence;Gender;Generations;Health;health related quality of life;Heavy Drinking;high risk drinking;high risk sexual behavior;Hispanic;Hispanic Populations;Individual;Intervention;junior high school;Knowledge;Life;Life Cycle Stages;Link;Longitudinal Studies;Measures;Medical Marijuana;Mental Health;misuse of prescription only drugs;multi-ethnic;Neighborhoods;outcome prediction;Pattern;peer;Persons;physical conditioning;Play;Policies;Positioning Attribute;Prevention;protective factors;Psyche structure;Public Policy;Race;racial disparity;racial diversity;recruit;Resistance;retention rate;Risk Behaviors;Risk Factors;Role;Sampling;satisfaction;school district;Self Efficacy;Shapes;sleep quality;social;Social Development;social media;social stressor;Structure;Students;Subgroup;Surveys;Time;Tobacco;transition to adulthood;university student;vaping nicotine;Vocation;Work;young adult;Youth

PROJECT_TITLE: Life Course Perspective on Alcohol and Drug Use Trajectories from Adolescence into Adulthood

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Recovery Support Services;Rehabilitation;Rural Health;Substance Misuse

ORG_CITY: JOHNSON CITY

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Recovery support services, alongside access to medications for opioid use disorder, are rapidly expanding in the wake of the opioid crisis, yet rigorous research on recovery support services continues to lag behind. The proposed activities will initiate the Studies To Advance Recovery Support (STARS) Network, a thematic, stakeholder-focused research network that will capitalize on an established research consortium to generate trainings, tools, and platforms targeted to the implementation and study of peer recovery support services for individuals treated with medications for opioid use disorder. The STARS Network is relevant to public health because it will provide a critical foundation for high-priority research on peer recovery support services that could inform the expansion of peer recovery support services and advance recovery among individuals with opioid use disorder.

PI_NAMEs: HORN, KIMBERLY A;PACK, ROBERT P (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: Achievement;Acute;Address;Agreement;Algorithms;Appalachian Region;Assessment tool;Automobile Driving;barrier to testing;career networking;certificate program;Clinic;clinical research site;Clinical Trials;cohort;Communities;community advisory board;community-centered;Consultations;Credentialing;Data;Data Analytics;Data Element;data harmonization;data infrastructure;data lake;data sharing;design;Development;Ecosystem;Education;Enrollment;experience;Failure;falls;Family;FDA approved;Fostering;Foundations;Geography;Goals;Guidelines;Health Services Accessibility;Health Services Research;Health system;Healthcare Systems;Horns;improved;improved outcome;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;Intervention Studies;Leadership;Lived experience;Mediating;medication for opioid use disorder;Mentors;Methods;Mission;Modeling;National Institute of Drug Abuse;network models;novel;Opioid;opioid epidemic;opioid use disorder;Outcome;outreach;overdose death;patient oriented;patient population;peer;peer recovery;Pharmaceutical Preparations;Process;Protocols documentation;provider intervention;Public Health;Qualifying;Readiness;Recommendation;Recovery;recovery services;Recovery Support;Registries;Research;research and development;Research Personnel;Research Priority;Research Training;Resources;response;service intervention;Site;skills;Structure;success;support network;Support System;Technology;Testing;Time;tool;Training;Training Activity;Translations;Treatment outcome;trial design;Trust;Universities;Virginia;Work

PROJECT_TITLE: Studies to Advance Recovery Supports (STARS) in Central Appalachia


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: PROJECT NARRATIVE Obesity disproportionately impacts sexual minority women. This K23 seeks to improve obesity treatments for this at-risk and underserved group by tailoring and optimizing an evidence-based online behavioral weight loss program to enhance weight loss in sexual minority women. Findings from this study will identify a finalized obesity treatment package for sexual minority women that will be evaluated in a future randomized controlled trial as a promising treatment for reducing obesity and health disparities in this group.

PI_NAMEs: PANZA, EMILY  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Affect;Behavior;Behavior Therapy;Behavioral;Bisexual;Body Image;Body Weight decreased;cardiometabolism;cardiovascular disorder risk;career;Clinical;clinically significant;cost;Data;design;Diabetes Mellitus;Diet;Disparity;Eating;Evaluation;evidence base;Exercise;experience;experimental study;Feedback;Focus Groups;Future;gender minority health;Goals;Grant;Health;health disparity;Heterosexuals;improved;individualized medicine;innovation;Institute of Medicine (U.S.);interest;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Learning;Lesbian;LGBT Health;Mediation;Mental Depression;Mentors;Mentorship;Methods;minority stress;moderate obesity;multiphase optimization strategy;novel;Obesity;obesity treatment;Outcome;Overweight;Persons;Phase;phase 3 study;Physical activity;pilot test;Population;Preparation;programs;Public Health;Qualifying;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Research Priority;Risk;Same-sex;Sexual and Gender Minorities;Sexual Health;sexual minority;sexual minority women;Shapes;skill acquisition;skills;Social support;standard care;Stress;Stress and Coping;Structure;substance use;Technology;Testing;theories;therapy development;Training;treatment optimization;Underserved Population;United States National Institutes of Health;Weight;Weight Gain;weight loss intervention;weight loss program;Wing;Woman;Work

PROJECT_TITLE: Using the Multiphase Optimization Strategy to Optimize a Culturally Tailored Online Behavioral Weight Loss Intervention for Sexual Minority Women


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Nashville

ORG_DEPT: NEUROSCIENCES

ORG_NAME: VANDERBILT UNIVERSITY

PHR: Cocaine use disorder (CUD) is a devastating syndrome that significantly affects the lives of the individuals that suffer from it. At the core of CUD is maladaptive drug seeking and drug taking. The goal of this project is to define how drug-induced dysregulation in brain reward systems underlies deficits in motivation to drive behaviors associated with CUD.

PI_NAMEs: EMERSON, SOREN D (contact)

PROJECT_TERMS: Acetylation;Acetyltransferase;Acute;addiction;Address;Affect;Animals;awake;Behavior;behavioral economic analysis;behavioral response;Bioinformatics;Brain;cell type;Cells;Chromatin;Cocaine;cocaine exposure;cocaine related behaviors;cocaine reward;cocaine seeking;cocaine self-administration;Cocaine use disorder;Complex;Consumption;Control Animal;Cues;Data;Disease;DNA;DNA Packaging;DNA Structure;Dopamine;Dose;drug induced behavior;drug of abuse;drug seeking behavior;Enzymes;Epigenetic Process;epigenetic regulation;Event;Exposure to;FDA approved;Female;Fiber;Gene Expression;Gene Expression Regulation;Gene Transfer;Genes;Genetic Transcription;Goals;Histone Acetylation;histone acetyltransferase;Histone H3;Histones;Impairment;in vivo;Individual;Knowledge;Link;loss of function;Lysine;Maintenance;maladaptive behavior;male;Measures;Mediating;Molecular;molecular marker;Motivation;Mus;mutant;Mutation;neural;Neurons;novel;Nuclear;Nucleosomes;Nucleus Accumbens;optical imaging;Output;overexpression;Pharmaceutical Preparations;Pharmacotherapy;Photometry;Physiological;Play;Population;postmitotic;Proteins;Proteomics;Public Health;receptor;recruit;Regulation;Reinforcement Schedule;response;Rewards;Rodent Model;Role;Self Administration;Series;Stimulus;Substance Use Disorder;Syndrome;System;Tail;Testing;Training;Transcriptional Regulation;Viral;virtual;Withdrawal;Work

PROJECT_TITLE: Defining the cell-type specific role of histone acetyltransferase KAT2a in nucleus accumbens D1 medium spiny neurons as a driver of cocaine use disorder


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease;Regenerative Medicine;Substance Misuse

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. We proposed to determine how hepatocytes from different zones regenerate the liver in ALD. We will ask if cells in zone 2 are critical for tissue healing, and if the Igfbp2 and Hamp1/2 genes are important for the normal functioning of these cells.

PI_NAMEs: ZHU, HAO  (contact)

PROGRAM_OFFICER_NAME: GAO, PETER

PROJECT_TERMS: Acceleration;Alcoholic Liver Diseases;Alcohols;Cell Physiology;Cell Proliferation;Cells;Chronic;Contracts;CRISPR screen;Data;Disease;Enzymes;Ethanol;Exhibits;Exposure to;FRAP1 gene;Frequencies;gain of function;Genes;Genetic Transcription;healing;Hepatic;Hepatocyte;hepcidin;Homeostasis;Human;Impairment;in vivo;Injury;Iron;Iron Overload;Iron Uptake Inhibition;Label;Liver;liver cell proliferation;liver injury;Liver Regeneration;Lobular;loss of function;Maps;Metabolic;Modeling;Morbidity - disease rate;mortality;Natural regeneration;non-alcoholic fatty liver disease;overexpression;Pathogenesis;Patients;Population;Production;Proliferating;Reactive Oxygen Species;regenerative;Regulation;response;single-cell RNA sequencing;Source;success;Time;tissue repair;Tissues

PROJECT_TITLE: Determining how chronic ETOH influences the regenerative activities of hepatocyte subpopulations

STUDY_SECTION: HBPP

STUDY_SECTION_NAME: Hepatobiliary Pathophysiology Study Section[HBPP]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

PHR: PROJECT NARRATIVE The Million Veteran Program (MVP) constitutes the largest and most comprehensive biobank in the world, including multi-ancestry genetic data from more than 650,000 Veterans and dense electronic health records that fully captures the clinical characteristics of each participant. MVP provides a unique opportunity to perform large- scale genetic analyses and further our understanding of Precision Psychiatry across multiple traits and diseases. Here, we propose to leverage MVP data, integrate them with brain molecular profiling data, and perform a comprehensive analysis to investigate the functional roles of variants associated with serious mental illness that affect a great proportion of our Veterans. In addition to the tremendous burden of suffering and economic costs, these diseases increase the mortality rate among Veterans. Thus, this study is aimed at addressing the need for understanding the pathophysiology, identifying key drivers, and testing novel approaches to genetically informed customized treatment or prevention tailored to the individual characteristics of each patient.

PI_NAMEs: ROUSSOS, PANAGIOTIS  (contact)

PROJECT_TERMS: Address;Affect;Area;Autoimmune;Awareness;biobank;Biological;Brain;Brain region;brain tissue;causal variant;cell type;Cells;Characteristics;Chromatin;Clinical;Code;Communities;COVID-19;Data;Data Set;Death Rate;deep learning;Detection;Development;Disease;disorder risk;drug development;drug discovery;drug efficacy;Drug Targeting;economic cost;Electronic Health Record;Epigenetic Process;epigenome;Functional disorder;Future;Gene Expression;gene interaction;Gene Targeting;Generations;Genes;Genetic;genetic analysis;genetic architecture;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;Genomic approach;Genomics;Genotype;Goals;Graph;Heritability;High Prevalence;histone modification;Human;improved;indexing;Individual;individualized medicine;Intervention;Joints;large scale data;Libraries;Machine Learning;Methods;Modeling;Molecular;Molecular Profiling;molecular scale;multiple omics;neuropsychiatry;next generation;novel;novel strategies;Outcome;Participant;Pathway interactions;patient subsets;Patients;Pharmaceutical Preparations;phenome;Phenotype;Positioning Attribute;precision medicine;predictive modeling;Prevention;programs;Proteome;Proteomics;Psychiatry;psychopharmacologic;Regulation;Research;Research Personnel;Resolution;Resources;Risk;risk variant;Role;Sampling;severe mental illness;Specificity;Structure;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;Therapeutic Intervention;Tissues;trait;transcriptome;transcriptomics;treatment response;Untranslated RNA;Variant;Veterans

PROJECT_TITLE: Large-scale transcriptome and epigenome association analysis across multiple traits


ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: PROJECT NARRATIVE The interruption of the blood supply to the brain causes induces the detachment of contacts between neurons with the subsequent impairment of transmission of information. This process is initially reversible, but after variables period of time becomes irreversible and leads to the development of permanent neurological deficits. In this application we will study the mechanism whereby the different compartment of the synapse detach from each other during an ischemic stroke. We will then use this knowledge to develop a therapeutic strategy to induce the re-attachment of those components before the development of permanent functional deficits. We postulate that this will improve the functional outcome following an acute ischemic stroke.

PI_NAMEs: YEPES, MANUEL SALVADOR (contact)

PROJECT_TERMS: Acids;Acute;Alteplase;Animal Model;aspartate receptor;Binding;Blood - brain barrier anatomy;Brain;Brain Hypoxia-Ischemia;Cerebral Ischemia;Cyclin-Dependent Kinase 5;Data;Degradation Pathway;density;Development;Endocytosis;Endothelial Cells;Event;experimental study;functional improvement;Generations;Hemorrhage;Impairment;improved;In Vitro;in vivo;Interruption;Intravenous;intravenous administration;Ischemia;ischemic injury;Ischemic Stroke;Knowledge;Laboratories;Mediating;Membrane;multicatalytic endopeptidase complex;N-Methylaspartate;neurobehavioral;Neurologic Deficit;Neurological outcome;Neurons;novel;Phase;Phosphorylation;Plasmin;Plasminogen;Plasminogen Activator;postsynaptic;postsynaptic density protein;Presynaptic Terminals;Process;Property;Protein Kinase;Publishing;receptor;Recombinants;recruit;response;Role;scale up;Serine Protease;Site;stroke patient;Synapses;Synaptic Cleft;synaptic failure;synaptic function;Synaptic plasticity;System;Techniques;Testing;Therapeutic;Time;Tissues;transmission process;Ubiquitin;Ubiquitination;Vascular blood supply;Work

PROJECT_TITLE: TPA Protects the Synapse in the Iscemic Brain


ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: The proposed research is relevant to public health because unmet social needs negatively influence health, increase utilization, perpetuate disparities, and increase health care costs. The proposed research is relevant to AHRQ's mission to safer, higher quality, and more affordable care by supporting efficient and effective delivery of services.

PI_NAMEs: VEST, JOSHUA RYAN (contact)

PROGRAM_OFFICER_NAME: SWIGER, JAMES

PROJECT_TITLE: Predictive modeling for social needs in emergency department settings

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Services;Patient Safety

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Syncope, or transient loss of consciousness, is a common reason for visit to the Emergency Department and often leads to extensive testing and hospitalization. Using objective risk scores to determine which patients with syncope will actually benefit from these interventions, and which can be safely discharged home with minimal testing, is critical to providing sensible medical care. Our study will evaluate the validity of two syncope risk-stratification tools and investigate their impact on healthcare utilization and patient safety, thus improving the quality of care for the 1-2 million patients who experience syncope every year in the United States.

PI_NAMEs: PROBST, MARC  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Accident and Emergency department;acute coronary syndrome;Admission activity;Adult;Age;Algorithms;Arrhythmia;Benign;Cardiac;Caring;Clinical;clinical care;Clinical Data;clinical implementation;Clinical Management;clinical practice;cost;Data;Derivation procedure;Electrocardiogram;Eligibility Determination;Emergency Care;Emergency Department patient;Emergency department visit;Emergency Situation;Enrollment;Esthesia;Evaluation;experience;Funding;Goals;Health Care Costs;health care service utilization;health record;health service use;Health system;high risk;Home;Hospitalization;Hospitals;Iatrogenesis;improved;Intervention;Judgment;Knowledge;Laboratories;Measures;Medical;Methodology;Minority;Myocardial Infarction;Names;National Heart, Lung, and Blood Institute;novel;Observational Study;Outcome;patient population;patient safety;patient stratification;Patients;Performance;Physicians;Play;Population;prospective;Publishing;Pulmonary Embolism;Pulmonary Heart Disease;Quality of Care;Research;Research Assistant;Research Personnel;Research Training;Resources;response;Risk;risk prediction;risk stratification;Role;Sensitivity and Specificity;Site;Syncope;Testing;tool;Unconscious State;United States;Validation;Visit

PROJECT_TITLE: Practical Approaches to Care in Emergency Syncope (PACES)

STUDY_SECTION: HSOD

STUDY_SECTION_NAME: Health Services Organization and Delivery Study Section[HSOD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative  This T32 proposal will establish the first transdisciplinary postdoctoral training program focusing on transdiagnostic, neurodevelopmental mechanisms of psychopathology, with an expanded focus on lifespan and environmental context. All postdoctoral fellows will have two co- mentors: (1) A co-mentor with expertise in neurodevelopmental and/or environmental mechanisms of psychopathology; and (2) a co-mentor in one of the following areas: (a) prevention, intervention, or implementation, (b) computational psychiatry and data science, or (c) the intersection of mental health and pediatric health. The transdisciplinary mentorship and didactic training will launch the next generation of neurodevelopmental clinical science researchers poised to accelerate the pace of clinical translation.

PI_NAMEs: SHANKMAN, STEWART AARON (contact);WAKSCHLAG, LAUREN S

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Northwestern University Mental Health, Earlier: Transdiagnostic, Transdisciplinary, Translational Training Program in Neurodevelopmental Mechanisms of Psychopathology


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Cancer

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: NARRATIVE Extracellular vesicles, especially the exosomes, have been recognized as a novel and highly effective means of cell-cell communication. Recent studies have implicated exosomes in many pathophysiological processes such as cardiovascular development, host-pathogen interaction, neuronal degeneration, and cancer. Studying the molecular basis of exosomal trafficking, and how exosome biogenesis is regulated by oncogenic signaling will not only provide the fundamental understanding of exosome trafficking, but also open new venues for therapeutic targeting of exosomes in cancer diagnosis and treatment.

PI_NAMEs: GUO, WEI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Affect;Behavior;Biochemistry;Biogenesis;Biological;Cancer Biology;cancer diagnosis;cancer therapy;Cardiovascular system;Cell Communication;Cell membrane;Cell secretion;Cells;Cellular biology;Complex;Development;Docking;Encapsulated;endosome membrane;Endosomes;exosome;extracellular;extracellular vesicles;Family;Foundations;Goals;Immune Evasion;Immune system;Immunobiology;Immunosuppression;interdisciplinary approach;interest;Lipids;Malignant Neoplasms;Mediating;Metastasis Suppression;MicroRNAs;Microtubules;Mitogen-Activated Protein Kinases;Molecular;Monomeric GTP-Binding Proteins;Motor;Multivesicular Body;neoplastic cell;Nerve Degeneration;novel;Oncogenic;Organogenesis;pathogen;Process;Proteins;Research;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;therapeutic target;trafficking;Tumor Biology;tumor growth;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Suppression;Tumor-Associated Process;Vesicle;Viral;Work

PROJECT_TITLE: Molecular Basis and Regulatory Mechanisms of Exosome Secretion

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ORG_CITY: Prairie View

ORG_NAME: PRAIRIE VIEW AGRI & MECH UNIVERSITY

PHR: U-RISE at PVAMU PI: E. Gloria C. Regisford, PhD Project Narrative: An historically black University/College (HBCU), Prairie View A&M University (PVAMU) is evolving into an institution that places emphasis on engaging all undergraduates in nondidactic activities, such as research experiences/internships. In alignment with this mission, the goal of the proposed U-RISE at PVAMU program is to enhance student participation and preparation in the biomedical sciences for matriculation into highly competitive PhD programs and ultimately, a research career. The U-RISE at PVAMU program will contribute to the enrichment of the academic and research culture at this institution and will lead to an increase in PhD program matriculation and completion, and ultimatelyto a more diverse biomedical research workforce.

PI_NAMEs: REGISFORD, E GLORIA CLAUDETTE (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: academic preparation;Biology;career;Chemistry;Collaborations;community engagement;COVID-19 pandemic;Dimensions;Discipline;Doctor of Philosophy;educational atmosphere;Educational Curriculum;Elements;Enrollment;Ethnic Origin;evidence base;Faculty;First Generation College Students;Fostering;Future;Goals;graduate school;Graduation Rates;hands on research;Historically Black Colleges and Universities;improved;Interdisciplinary Study;interest;learning community;matriculation;member;Mentors;Modeling;Motivation;multidisciplinary;Outcome;Population Heterogeneity;Preparation;professor;programs;Race;Research;Research Training;Science;Scientist;skill acquisition;socioeconomic disadvantage;STEM career;student participation;Students;Training;undergraduate research;undergraduate student;Underrepresented Populations;Universities

PROJECT_TITLE: U-RISE at PVAMU

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Substance Misuse;Traumatic Head and Spine Injury

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Alcohol is the most commonly used and abused drug in the United States. Chronic alcohol abuse results in neuronal degeneration and functional deficits in sensory-motor, memory, psychological, and cognitive functions. In this proposal, we hypothesize that the neuroinflammation, neurodegeneration, and cognitive deficits resulting from alcohol-induced oxidative damage can be repaired by activating the antioxidant signaling Nrf2 (nuclear factor E2-related factor 2) pathway using a small Nrf2 activator III peptide (briefly called as Nrf2 peptide). We will validate the effect of Nrf2 peptide with Nrf2 KO (Nrf2-/-) mice. We will use a cohort of behavioral tests that include cognitive and sensory-motor functions, and psychological stress to validate the effect of Nrf2 peptide in functional recovery in AUD.

PI_NAMEs: MUNEER, MOHAMMED ABDUL (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: Alcohol abuse;Alcohol consumption;alcohol effect;alcohol exposure;Alcohol-Induced Disorders;Alcohols;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Animals;Anti-Inflammatory Agents;antioxidant enzyme;Antioxidants;Anxiety;Apoptotic;ATF2 gene;behavior test;Behavioral;Binding Sites;Biochemical;Blood - brain barrier anatomy;Brain;Brain Injuries;Cell Death;Cells;central nervous system injury;Cerebellum;ChIP-seq;Chronic;Chronic Disease;Clinical;clinically relevant;Cognitive;Cognitive deficits;cognitive function;cohort;Cytoprotection;Darkness;Data;Defense Mechanisms;Disease;Drug Metabolic Detoxication;drug of abuse;Feedback;Free Radicals;Functional disorder;Gene Expression;gene interaction;Gene Proteins;Genes;Genetic Transcription;Goals;Heavy Drinking;Hippocampus;Impairment;in vivo;Inflammatory;Injections;Investigation;Knock-out;Knockout Mice;Knowledge;Light;Matrix Metalloproteinases;Mediating;Memory;Memory impairment;Mental Depression;Motor;Multiple Sclerosis;Mus;Nerve Degeneration;Nervous System Trauma;neural;Neurocognitive Deficit;neuroinflammation;Neurologic;Neurologic Deficit;neuron loss;neuropathology;neuroprotection;new therapeutic target;novel;Nuclear;Nuclear Translocation;Nucleic Acid Regulatory Sequences;Oxidants;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Parkinson Disease;Pathway interactions;Penetration;Peptides;preference;Prefrontal Cortex;prevent;problem drinker;Proteins;psychologic;Psychological Stress;Publishing;Recovery;Recovery of Function;Regulation;remediation;repaired;Reporting;Research Personnel;Resistance;response;Response Elements;Role;Sensory;Signal Pathway;Signal Transduction;Stroke;subcutaneous;Sucrose;System;Testing;Therapeutic;Therapeutic Agents;Therapeutic Intervention;therapeutic target;Toxic effect;Transcription Coactivator;transcription factor;Transforming Growth Factors;Traumatic Brain Injury;United States;Up-Regulation;Work

PROJECT_TITLE: Peptide therapy for alcohol-induced CNS injury

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: FORT COLLINS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: COLORADO STATE UNIVERSITY

ORG_STATE: CO

PHR: Project Narrative Experiments described in this proposal examine how synaptic activity and calcium signaling regulate long-distance molecular motor transport for delivery and removal of synaptic glutamate receptors. This is important because delivery and removal of receptor affect synaptic transmission, learning and memory. The ultimate goal of this project is to help human health by stimulating the development of pharmaceuticals that can modulate molecular motor transport thereby affecting cognition and neurodegeneration, but also potentially diabetes and cancer.

PI_NAMEs: HOERNDLI, FREDERIC J (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affect;AMPA Receptors;Animals;Behavior;Behavior Control;Biochemical;Biochemistry;biological systems;C-terminal;Caenorhabditis elegans;Calcium;Calcium Signaling;Calmodulin;Cell Culture Techniques;Cell model;Cells;Cognition;cognitive function;Complex;Data;Dendrites;Development;Diabetes Mellitus;Event;Excision;experimental study;Genetic;Genetic Structures;Glutamate Receptor;Glutamates;Goals;Health;Homologous Gene;Human;human disease;improved;in vivo;Induced Neurons;insight;Investigation;Kinesin;LAR tyrosine phosphatase receptor;Learning;Link;Literature;Maintenance;Malignant Neoplasms;MAP Kinase Gene;Measures;Mediating;Memory;Microscopy;Microtubules;model organism;Modeling;Modification;Molecular Motors;Motor;mutant;Mutation;N-terminal;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;neuronal cell body;neuronal circuitry;Neurons;neurotransmission;new therapeutic target;optogenetics;Output;Pharmacologic Substance;Phosphotransferases;Photobleaching;Play;postsynaptic;predictive modeling;Property;Protein Isoforms;Protein Tyrosine Phosphatase;Proteins;Publications;receptor;receptor function;recruit;Regulation;response;Role;scaffold;Signal Pathway;Signal Transduction;Site;spatiotemporal;Speed;Structure;Synapses;synaptic function;Synaptic plasticity;Synaptic Receptors;Synaptic Transmission;Testing;Time;trafficking;Validation;Vertebrates;vesicle transport;Visualization

PROJECT_TITLE: In Vivo Investigations of AMPA receptor transport

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Neurosciences;Schizophrenia

ORG_DEPT: PHARMACOLOGY

PHR: Evidence suggests that activators of the metabotropic glutamate (mGlu) receptor mGlu1 subtype in the brain have exciting potential as novel treatments for positive symptoms and cognitive disturbances in patients suffering from schizophrenia. We propose a series of studies aimed at developing a better understanding of the roles of mGlu1 in brain circuits that are disrupted in schizophrenia patients and the therapeutic potential of selective activators of mGlu1.

PI_NAMEs: CONN, P JEFFREY (contact)

PROJECT_TERMS: Address;Amphetamines;antagonist;Antipsychotic Agents;associated symptom;Behavior;Behavioral;behavioral response;Biosensor;Brain;cannabinoid receptor;cell type;Cells;Clinical Research;CNR2 gene;Cognitive deficits;Corpus striatum structure;Data;Delusions;Disease;Disinhibition;Dopamine;Dopamine D1 Receptor;dopaminergic neuron;Electrophysiology (science);Endocannabinoids;Fiber;Genes;Genetic;genetic approach;Genetic study;genome wide association study;GRM1 gene;Hallucinations;Human;Human Genetics;Impaired cognition;improved;insight;Interneurons;Knockout Mice;loss of function;Mediating;Medical Genetics;Memory impairment;Metabotropic Glutamate Receptors;Modeling;Modernization;Motor;Motor Activity;Mus;Muscarinic Acetylcholine Receptor;N-Methyl-D-Aspartate Receptors;Neurons;novel;novel strategies;optogenetics;Parvalbumins;Pathologic;Patients;Periodicity;Photometry;Play;Population;positive allosteric modulator;pre-clinical;preclinical study;Prefrontal Cortex;Prosencephalon;Pyramidal Cells;response;Rodent;Rodent Model;Role;Scanning;Schizophrenia;selective expression;Sensory;Series;Short-Term Memory;Signal Transduction;Single Nucleotide Polymorphism;Somatostatin;Spinal;Symptoms;synaptic inhibition;Testing;Therapeutic;tool;transmission process;Viral;Whole-Cell Recordings

PROJECT_TITLE: Functions of Metabotropic Glutamate Receptor Subtypes

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: High grade serous cancers arise in the fallopian tube and exhibit a high proclivity to metastasize to the ovary as their primary metastatic site and omentum as a secondary site. Our team developed novel imaging mass spectrometry workflows to interrogate 3D organ culture systems co-cultured with fallopian tube derived tumor models to study the chemical crosstalk that occurs during metastasis. Overall, these data provide important new tools to uncover the signaling that occurs between organs and cells as it relates to the ovarian microenvironment in high grade serous metastasis.

PI_NAMEs: BURDETTE, JOANNA E (contact);SANCHEZ, LAURA MARGARET

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: 3-Dimensional;Adhesions;Adrenergic Antagonists;Adrenergic beta-Antagonists;Adrenergic Receptor;Anatomy;Automobile Driving;beta-adrenergic receptor;Biological;Biological Assay;Biological Models;Biology;cancer cell;Cell Communication;Cell model;Cells;Cessation of life;Chemicals;Chemistry;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Communication;Consumption;Data;Detection;Development;Disease;Emerging Technologies;Epithelial Cells;Epithelium;Equipment and supply inventories;Event;Exhibits;folate-binding protein;Folic Acid;Freezing;Genetic;Glycogen;Human;in vivo;innovation;Invaded;Ions;Knock-out;Ligands;Lipids;Location;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;mass spectrometric imaging;Measures;Mediating;metabolome;metabolomics;Metastatic Malignant Neoplasm to the Ovary;Methodological Studies;migration;Modeling;mortality;Mus;Mutation;Names;Neoplasm Metastasis;neoplastic cell;Newly Diagnosed;Norepinephrine;novel;Omentum;Organ;Organ Culture Techniques;Ovarian;Ovary;overexpression;Pathway interactions;Patient-Focused Outcomes;Peritoneal;Peritoneum;Process;Production;Protein Secretion;Proteins;Proteomics;Protocols documentation;Role;Route;Sampling;Series;Serous;Signal Pathway;Signal Transduction;Site;small molecule;Source;Spatial Distribution;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;spheroids;System;Techniques;Technology;Testing;therapeutic target;three dimensional cell culture;Time;Tissues;tool;Translating;tumor;Tumor Cell Invasion;Tumor Cell Migration;Tumor Expansion;tumorigenic;Work;Xenograft procedure

PROJECT_TITLE: Imaging mass spectrometry methodologies for studying the metabolites of cancer metastasis

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ORG_CITY: FARMINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: Cilia are cellular extensions that play essential motile and signaling roles in human development and biology. This study will investigate the mechanisms by which the dynein motors that power ciliary motility are assembled and controlled. It will also study the role of peptide amidation in cilia formation, and how cilia-derived bioactive amidated products participate in cell-cell communication.

PI_NAMEs: KING, STEPHEN M (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Address;amidation;Area;arm;Biochemical;Biology;Cell Communication;Cells;Chemotaxis;Chlamydomonas;Cilia;ciliopathy;cilium biogenesis;Cilium Microtubule;cilium motility;Complex;Cytoplasm;Defect;Development;Dynein ATPase;Environment;Enzymes;extracellular;Failure;fluid flow;Fractionation;Genes;genetic approach;Green Algae;Human;Human Biology;Human Development;insight;interest;Laboratories;Location;macromolecular assembly;Methods;Microtubules;Mixed Function Oxygenases;Modeling;molecular array;Motility;Motor;novel;Organelles;Oxidation-Reduction;Pathway interactions;Peptides;Play;Process;receptor;Regulation;response;Role;Signal Pathway;Signal Transduction;Source;Syndrome;System

PROJECT_TITLE: The Biology of Motile Cilia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The proposed research is relevant to NIH’s mission because will shed light on the processes of human growth and development with the potential to improve health. More specifically, the work proposed is expected to define the mechanisms responsible to increase risk of prediabetes in offspring generated with widely used fertility treatments. These studies are expected to have an important impact because of the translational value to the fields of developmental reprogramming, diabetes, obesity and for patients affected with infertility.

PI_NAMEs: RINAUDO, PAOLO  (contact)

PROGRAM_OFFICER_NAME: RAVINDRANATH, NEELAKANTA

PROJECT_TERMS: Adult;Adult Children;adverse outcome;Affect;Amino Acids;Assisted Reproductive Technology;Beta Cell;Bioethics;Biological Markers;blastocyst;blood glucose regulation;career;Cells;Child;Chromatin;Clinical;clinically relevant;Closure by clamp;Conceptions;Congresses;critical period;Cues;Data;Data Set;Defect;Development;Diabetes Mellitus;Disease;disorder risk;Embryo;Embryonic Induction;Energy-Generating Resources;Environment;Environmental Risk Factor;Enzymes;Epigenetic Process;Exhibits;extracellular;Fertilization in Vitro;fetal;Fetus;Functional disorder;Gene Expression;Gene Expression Profile;Genome;Germ Cells;Glucose;Glucose Intolerance;Glycolysis;Goals;Growth;Growth and Development function;Health;HIF1A gene;Histones;Homeostasis;Human;Hyperglycemia;Hypertension;Impairment;improved;In Vitro;in vivo;Incidence;Infertility;infertility treatment;Infusion procedures;Life;Link;Metabolic;Metabolic Pathway;metabolic phenotype;Metabolism;Mission;Mitochondria;Modeling;Molecular;Mus;National Institute of Child Health and Human Development;novel;Obesity;offspring;Organism;Outcome;oxidative damage;Oxygen;Pathway interactions;Patients;Phenotype;Physiology;Placenta;Placentation;Play;postnatal;Prediabetes syndrome;Procedures;Process;programs;protein expression;Reactive Oxygen Species;Research;Risk;Role;Secondary to;Shapes;Signal Transduction;Signaling Molecule;Site;Source;stable isotope;Stress;Technology;theories;Tissues;trend;United States National Institutes of Health;Waste Products;Work

PROJECT_TITLE: Altered metabolism in embryo generated by in vitro fertilization

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


NIH_SPENDING_CATS: Cancer;Genetics;Hematology;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Germline RUNX1-mutations in familial platelet disorder (FPD), establishing a pre-leukemic state in hematopoietic stem and progenitor cells, cause a life-long risk of developing leukemia in at least 40% of individuals at the median age of 33 years. Since the clinical symptoms and bone marrowcytokine profiling of FPD patients indicate increased inflammation, this proposal seeks to understand the cross-talk of RUNX1-mutations with inflammatory cytokines and its role in altering the functions of bone marrow niche and hematopoiesis. The results will determine novel therapeutic targets and offer premise of improved treatment options and preventive care for familial platelet disorder patients.

PI_NAMEs: MOHAMMADHOSSEINI, MONA  (contact)

PROGRAM_OFFICER_NAME: YABE, IDALIA MONTANO

PROJECT_TERMS: 3-Dimensional;Acute Myelocytic Leukemia;Address;Age;Apoptosis;Automobile Driving;Binding Sites;Biological Assay;Biology;Blood Coagulation Disorders;Blood Platelets;bone;Bone Marrow;Bone Marrow Aspiration;Bone Marrow Cells;Bone Marrow Diseases;Bone Marrow Transplantation;cancer predisposition;Cell Count;Cell Cycle;Cell Differentiation process;Cells;Classification Scheme;Clinical;Coculture Techniques;CRISPR/Cas technology;cytokine;Data;Defect;Development;Diagnosis;Differentiation and Growth;Disease;DNA;Eczema;Event;experimental study;Extracellular Fluid;Failure;Familial Platelet Disorder;Family;Flow Cytometry;Fright;Functional disorder;Gene Expression Profiling;Genes;Genetic;Genetic Transcription;Germ Lines;Germ-Line Mutation;Goals;Growth;Guidelines;Hematopoiesis;Hematopoietic;hematopoietic differentiation;Hematopoietic stem cells;Human;Hypersensitivity;Impairment;improved;In Vitro;in vivo;in vivo evaluation;Individual;Inflammation;Inflammatory;Inflammatory Response Pathway;Inherited;inhibitor;Knock-out;Knowledge;Label;Laboratories;Lead;leukemia;Ligands;Measures;Mediating;Megakaryocytes;mesenchymal stromal cell;Methods;Modeling;Monitor;mouse model;Mus;Mutate;Mutation;Myelogenous;Myeloid Progenitor Cells;Myeloproliferative disease;new therapeutic target;Outcome Study;Pathway Analysis;Pathway interactions;Patients;peripheral blood;pharmacologic;Population;Predisposition;Preleukemia;premalignant;Prevention;Preventive care;Probability;progenitor;Proliferating;protein function;Risk;Role;RUNX1 gene;self-renewal;Series;Signal Transduction;Skin;skin hypersensitivity;Solid Neoplasm;spheroids;Stains;stem;stem cell differentiation;stem cell function;stem cell growth;stem cells;Stress;Stromal Cells;Study models;Symptoms;Syndrome;Testing;transcription factor;transcriptome;Transplantation;Up-Regulation;Western Blotting;Wild Type Mouse;World Health Organization

PROJECT_TITLE: Cross-talk mechanisms between RUNX1 and inflammatory signals impacting functions of stem and progenitors in Familial Platelet Disorder.


ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: There is a potential link between the incidence of multiple sclerosis (MS), the most important demyelinating disease in human, and combat service as several vaccinations (anthrax, hepatitis B), viral infections, CNS toxins, and air pollutants may increase the risk of having MS among veterans. Here, we want to test if selective targeting of activated status of one component of the innate immune system (TLR2) by wild type TLR2- interacting domain of MyD88 (wtTIDM) peptide promotes the maturation of oligodendroglial progenitor cells and stimulate remyelination in animal models of demyelination. This study will enhance the possibility of developing an intranasal agent to stimulate remyelination in patients with multiple sclerosis and other demyelinating disorders.

PI_NAMEs: PAHAN, KALIPADA  (contact)

PROJECT_TERMS: adaptive immunity;Air Pollutants;Animal Model;Anthrax disease;Area;Autoimmunity;Axon;Bacteria;Binding;Caucasians;CD4 Positive T Lymphocytes;Cell Maturation;Cell Separation;Cells;Central Nervous System;central nervous system demyelinating disorder;Central Nervous System Viral Diseases;Chemicals;Chronic;combat;Cuprizone;Demyelinating Diseases;Demyelinations;design;Diagnosis;Dissociation;effective therapy;Endowment;Engineering;Etiology;European ancestry;Experimental Autoimmune Encephalomyelitis;experimental study;Exposure to;Flagellin;Genes;Genetic;glial activation;Gulf War;Hepatitis B;Human;Immune;in vivo;in vivo Model;Incidence;Inflammation;inhibitor;Injury;Innate Immune System;Intoxication;Intranasal Administration;Investments;knock-down;Knockout Mice;Lesion;Link;Mediating;member;Microglia;Modeling;Monitor;Multiple Sclerosis;multiple sclerosis patient;Mus;Mutate;Myelin;Natural Immunity;Neurology;new technology;novel;oligodendrocyte myelination;Oligodendroglia;Outcome;Pathogenesis;Peptides;Persons;Play;Proliferating;prospective;remyelination;Research;response;Risk;Role;Services;Signal Transduction;Specificity;stem cells;T-Lymphocyte;Testing;Therapeutic;TLR2 gene;Toll-like receptors;Toxin;United States;Vaccination;Veterans;Vietnam;Viral;Virus;Virus Diseases;War;Wild Type Mouse

PROJECT_TITLE: Remyelination by intranasal TIDM peptide


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Burden of Illness;Cardiovascular;Clinical Research;Diabetes;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative Non-adherence to medications and treatment recommendations due to costs is an important driver of the socioeconomic status (SES) gradient in health outcomes among adults with Type 2 diabetes.1 Value Based Insurance Design (VBID) strategies that lower out-of-pocket costs for both diabetes medications and disease management visits may improve treatment compliance and health outcomes among adults with low SES; however, little is known about the effects of VBID in this population. Understanding the short and long-term health, disability and healthcare costs impacts of VBID among low SES adults with diabetes and how these effects vary across patient subgroups will be key for informing health insurance benefit design and efforts to improve health equity.

PI_NAMEs: NARAIN, KIMBERLY D (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Accident and Emergency department;Adherence;Adult;Aging;Appointment;Area;Award;burden of illness;cardiovascular risk factor;Caring;copayment;cost;Cost of Illness;Cost-Benefit Analysis;Costs and Benefits;Data;Data Set;design;Diabetes Mellitus;disability;Disability outcome;Disease Management;Disparity;Doctor of Philosophy;Drug Prescriptions;Economic Policy;Emergency department visit;Employee;Endocrinologist;Epidemiology;Face;Financial Hardship;Glycosylated hemoglobin A;Goals;Health;Health Benefit;Health Care Costs;health care service utilization;health equity;Health Insurance;health plan;Health Policy;Heterogeneity;High-Income Populations;hospital utilization;Hospitalization;Household;Hyperlipidemia;Hypertension;implementation design;improved;Income;Individual;insight;Insurance;Insurance Benefits;intervention program;Investments;K-Series Research Career Programs;Life Expectancy;low health literacy;Low income;low socioeconomic status;Low-Density Lipoproteins;Medical;medication compliance;Medication Management;middle age;models and simulation;Non-Insulin-Dependent Diabetes Mellitus;Outcome;patient subsets;Pharmaceutical Preparations;Policies;Population;Price;Primary Care;Privatization;programs;Quasi-experiment;Recommendation;Research Personnel;response;simulation;social implication;Social Policies;Socioeconomic Status;Subgroup;Surveys;therapy design;Time;treatment adherence;treatment effect;Uninsured Medical Expense;Visit;Wages;Work

PROJECT_TITLE: The Implications of Insurance Benefit Design for Health and Disability Among Low Income Adults with Diabetes.

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Public Health Relevance We propose to investigate the ability of individuals with treatment-resistant major depressive disorder (TR- MDD) to increase and sustain activity of the amygdala during positive memory recall, and relate this ability to outcomes that are clinically relevant for those with the disorder. We expect these studies to guide the development of non-pharmacological, non-invasive treatments to increase the processing of positive stimuli in patients with TR-MDD.

PI_NAMEs: YOUNG, KYM  (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Affect;Amygdaloid structure;anti-depressive agents;Autobiography;behavioral response;cerebral hemodynamics;Characteristics;Clinical;clinical effect;clinical efficacy;Clinical Trials;clinically relevant;Cognitive;Control Groups;daily functioning;depressive symptoms;Development;Diagnosis;Disease;Disease remission;Dose;Double-Blind Method;Educational Intervention;Emotional;Ensure;Evaluation;Functional disorder;Functional Magnetic Resonance Imaging;Goals;hemodynamics;improved;indexing;Individual;insight;Intervention;intervention refinement;Left;Major Depressive Disorder;Memory;memory recall;Mood Disorders;Moods;neurofeedback;Outcome;Parietal;Participant;Patients;Pharmaceutical Preparations;pharmacologic;Phase;Pilot Projects;Population;psychologic;public health relevance;Randomized;randomized, clinical trials;Recovery;Research;research clinical testing;Resistance;response;Sampling;Specificity;Stimulus;success;Symptoms;therapy development;therapy resistant;Time;Training;Treatment Efficacy;treatment response;treatment-resistant depression;Work

PROJECT_TITLE: Amygdala rtfMRI Neurofeedback for Treatment Resistant Depression


PHR: Narrative Non-alcoholic steatohepatitis (NASH) is a disease highly prevalent in patients with obesity and diabetes, that can increase the risk of heart disease. In some patients, NASH leads to liver failure or cancer. Women of reproductive age have lower rates of NASH. However, this protection is lost after menopause when NASH rates equal or exceed those for men. There is evidence that estrogen, in combination with growth hormone (GH), work together at the level of the liver to protect both men and women against NASH. Studies are proposed that will use unique mouse models with diet-induced NASH to better understand the basic mechanisms by which estrogen and GH prevent or slow NASH progression. This information can be used to unveil novel targets to develop drugs that can treat NASH.

PI_NAMEs: KINEMAN, RHONDA D (contact)

PROJECT_TERMS: Acute;Adult;Adult women;Age;Androgens;Boston;Breast Cancer Risk Factor;Cardiovascular Diseases;cardiovascular risk factor;Caring;cell type;Cells;cholangiocyte;Cirrhosis;Clinical;Collaborations;constitutive expression;Coupled;Data;Development;Diabetes Mellitus;diabetic patient;Diet;Disease;Disease Progression;drug clearance;Drug Targeting;Endothelium;Environmental Risk Factor;Estrogen Receptors;Estrogens;Etiology;feeding;Female;Feminization;Fibrosis;Future;Gene Expression;General Population;Genetic;Genomics;Growth Hormone Receptor;Health;heart disease risk;Hepatic;Hepatocyte;high risk;Hormonal;Hormone secretion;Hypothalamic structure;IGF1 gene;Immune;improved;Inflammation;innovation;insight;JAK2 gene;knock-down;Knowledge;Lipids;Literature;Liver;Liver Failure;male;Malignant Breast Neoplasm;Malignant neoplasm of liver;Mediating;men;Metabolism;mouse model;Mus;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;obese patients;Outcome;Pathology;Patients;Pattern;Pharmaceutical Preparations;Phenotype;Physiology;Pituitary Gland;Play;Population;Postmenopause;prevent;Primary carcinoma of the liver cells;Production;protective effect;Protein Hormone Receptor;Publishing;receptor;receptor-mediated signaling;Regulation;reproductive;reproductive axis;response;Role;Severities;sex;sexual dimorphism;Signal Transduction;simple steatosis;single nucleus RNA-sequencing;Somatotropin;Symptoms;Tamoxifen;Techniques;Technology;Testing;Tissue-Specific Gene Expression;Tissues;transcriptome sequencing;Translating;Universities;Veterans;Western Blotting;Woman;Women's Health;Work;Xenobiotics

PROJECT_TITLE: Hormonal control of NASH development and progression


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Chronic Pain;Contraception/Reproduction;Endometriosis;Pain Research;Women's Health Research

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE Successful completion of the proposed research will provide strong rationale to further develop our new innovative therapy to improve the health outcomes of patients with endometriosis. We will characterize the complex chronic inflammatory mechanisms involved and how they are inhibited by niclosamide. Because current treatment options are often of limited efficacy with high recurrence rates that elicit undesirable side effects, new medical treatments and identification of their targeting mechanisms are needed for endometriosis.

PI_NAMEs: HAYASHI, KANAKO  (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Adhesives;Affect;Age;Agonist;Ascites;associated symptom;behavior test;Cells;Chronic;chronic inflammatory disease;chronic pain;chronic pelvic pain;Complex;conditional knockout;cost;Data;debilitating pain;Development;Disease;Disease Progression;Dorsal;drug repurposing;effective therapy;endometriosis;Environment;Estrogens;Estrous Cycle;eutopic endometrium;Family;FDA approved;Fertility;Functional disorder;Ganglia;Gene Modified;GNRH1 gene;Growth;Gynecologic;Health;Hormonal;hormone therapy;Human;Hyperalgesia;Immune System Diseases;Immune Targeting;improved;Infiltration;Inflammation;Inflammatory;Innovative Therapy;Invaded;Knockout Mice;Laparoscopic Surgical Procedures;Length;Lesion;Litter Size;Macrophage;Medical;Morbidity - disease rate;mouse model;Mus;nerve supply;new therapeutic target;novel therapeutic intervention;novel therapeutics;Oral Contraceptives;Organ;Ovarian;Ovulation;Pain;Patient-Focused Outcomes;Patients;Pelvic cavity structure;Pelvis;Peritoneal;Peritoneal Fluid;Pharmaceutical Preparations;Pharmacotherapy;Population;Pregnancy;Pregnancy Rate;Production;Progestins;Publishing;Quality of life;Recurrence;reproductive;Research;Role;side effect;Signal Transduction;single-cell RNA sequencing;small molecule;Source;Spinal Ganglia;subfertility;Testing;therapeutic target;United States Food and Drug Administration;Uterus;Vagina;Vascularization;Woman

PROJECT_TITLE: Complex inflammatory mechanisms and therapeutic targeting in endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases;Influenza;Pneumonia and Influenza

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Structural studies of influenza hemagglutinin in complex with broadly neutralizing antibodies and designed inhibitors have established sites of vulnerability that are highly conserved across hemagglutinin subtypes. Here, we will develop and use novel high-throughput screening assays that permit the robust interrogation of the vulnerable and highly conserved site located within the hemagglutinin stem region of influenza A and B. Recurring recognition motifs and conserved pockets observed in our collection of HA crystal structures will provide a platform and strong foundation for the optimization of small molecule leads as therapeutic candidates to prevent influenza virus infection and pandemic threats.

PI_NAMEs: WILSON, IAN A (contact)

PROGRAM_OFFICER_NAME: BASU, DIPANWITA

PROJECT_TERMS: active method;Affinity;Animal Model;Animals;anti-influenza;Anti-viral Agents;Antibodies;Appearance;Binding;Binding Sites;Biochemical;Biological Assay;Biophysics;Biotechnology;Birds;Cells;Collection;combat;combinatorial;Communities;Complementarity Determining Regions;Complex;cost effective;Cyclic Peptides;design;Development;Disease;drug discovery;Drug Targeting;Economic Burden;Epidemic;Exhibits;feature detection;fitness;flu;Fluorescence Polarization;Fluorescence Resonance Energy Transfer;fluorophore;Foundations;Future;Goals;Half-Life;Head;Health;Hemagglutinin;high throughput screening;Housing;Human;Hydrogen Bonding;Hydrophobicity;improved;Infection;Influenza;Influenza A virus;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H2N2 Subtype;Influenza A Virus, H3N2 Subtype;Influenza A Virus, H5N1 Subtype;Influenza A Virus, H7N7 Subtype;Influenza A Virus, H7N9 Subtype;Influenza A Virus, H9N2 Subtype;Influenza B Virus;Influenza Hemagglutinin;influenza infection;Influenza prevention;influenzavirus;inhibitor;innovation;interest;iterative design;Journals;Label;Laboratories;Lead;Libraries;Membrane;Membrane Glycoproteins;Mission;mutant;Mutation;nanomolar;Nature;Neuraminidase;neutralizing antibody;new pandemic;novel;novel therapeutics;pandemic disease;pandemic influenza;pandemic potential;pathogenic virus;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Point Mutation;Predisposition;prevent;Property;Proteins;Publishing;rational design;receptor binding;Recurrence;Reporter;Resistance;Roentgen Rays;scaffold;Science;seasonal influenza;Seasons;Serotyping;Signal Transduction;Site;small molecule;small molecule libraries;Specificity;stem;stoichiometry;Structure;Surface;Surface Antigens;therapeutic candidate;tool;United States National Institutes of Health;Viral;Viral Physiology;Virus;X-Ray Crystallography;Zoonoses

PROJECT_TITLE: High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-F(55)R]


NIH_SPENDING_CATS: Neurosciences;Rare Diseases

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative: Glycogen metabolism is impaired in >20 individual rare genetic diseases with several diseases being caused by the accumulation of insoluble glycogen in liver, muscle, heart, and/or brain tissue. This proposal studies the molecular mechanisms underlying the prevention of pathogenic insoluble glycogen. We (1) provide a better grasp of vital cellular processes that maintain water-solubility of glycogen to function as a central metabolite for energy storage and utilization and (2) lay the foundation for new therapeutic approaches for several rare diseases with insoluble glycogen accumulation.

PI_NAMEs: NITSCHKE, FELIX  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Affect;Binding Proteins;biochemical tools;Biochemistry;Biological Process;brain tissue;Cell Physiology;Cells;Characteristics;Data;Deposition;Disease;Foundations;Genetic;genetic manipulation;Glycogen;Glycogen Branching Enzyme;glycogen metabolism;Goals;grasp;Hand;Health;Heart;Impairment;improved;In Vitro;in vivo;Individual;inorganic phosphate;Knowledge;Lafora Disease;Link;Liver;Modeling;Molecular;mouse model;Mus;Muscle;neuropathology;novel;novel therapeutic intervention;overexpression;Pathogenicity;Pathology;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiological;polyglucosan;Positioning Attribute;Precipitation;prevent;Prevention;Prevention approach;Proteome;Proteomics;Publishing;Rare Diseases;rare genetic disorder;reconstitution;Regulation;Risk;Role;Solubility;Testing;Therapeutic;tool;Water;water solubility;Work

PROJECT_TITLE: Uncovering cellular mechanisms to keep glycogen water-soluble

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Genetics

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: Upstream Open Reading frames (uORFs) are important cis-regulatory elements that control mRNA translation and decay. Although the human genome encodes thousands of uORFs, only a small number have been experimentally tested and many questions remain regarding their function and regulation. We propose to use novel high- throughput approaches to determine the functions of human uORFs, evaluate their importance in cellular stress responses, and investigate their potential regulation by RNA Binding Proteins.

PI_NAMEs: MCMANUS, CHARLES JOEL (contact)

PROGRAM_OFFICER_NAME: CZAPLINSKI, KEVIN

PROJECT_TERMS: Address;Binding Sites;Biological Assay;Cellular Stress;Cis-Acting Sequence;Computer Analysis;Computer Models;Disease;Funding;Gene Expression Regulation;Genes;Genetic Transcription;Genotype;Goals;Human;human disease;Human Genome;human tissue;Initiator Codon;innovation;Knowledge;Laboratories;Link;Modeling;mRNA Decay;mRNA Translation;Mutation;novel;Open Reading Frames;Phenotype;posttranscriptional;Primates;Production;Proteins;Regulation;Regulatory Element;Reporter;Research;RNA-Binding Proteins;Role;Systems Biology;Testing;tissue culture;tool;Trans-Activators;Transcription Process;Translations;Yeasts

PROJECT_TITLE: Regulation of mRNA translation by cis-acting sequences and trans-acting factors

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Kidney Disease;Machine Learning and Artificial Intelligence;Organ Transplantation;Precision Medicine;Transplantation

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Characterization of Renal Allograft Fibrosis and Prediction of Outcome Using a Quantitative MRI Approach Project Narrative Caused by a variety of etiologies, acute and chronic renal allograft injury often results in the development of interstitial fibrosis/tubular atrophy (IFTA), is a significant cause of allograft failure and poor outcomes; the reference standard for which is tissue biopsy, which is limited due to sampling error and risk of complications. In this proposal, we will develop a short, non-contrast multiparametric MRI (mpMRI) protocol, consisting of advanced relaxometry (T1 mapping and T1) and advanced diffusion weighted imaging (IVIM-DWI) to accurately detect and stage allograft fibrosis, taking into account confounding Banff variables of inflammation and tested against biopsy. We will also assess the added value of urinary biomarkers of IFTA and if successful, this study will benefit a large population of patients with renal allograft fibrosis in the United States, enabling early diagnosis, optimized treatment planning, prognostication and longitudinal disease monitoring.

PI_NAMEs: BANE, OCTAVIA ;LEWIS, SARA C (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute;Affect;Allografting;antifibrotic treatment;Area;Atrophic;Biological Markers;Biopsy;Blood Vessels;Caring;Chronic;Chronic Kidney Failure;Classification;Clinical;clinical encounter;clinically significant;cohort;Collagen;comparative;Data;Detection;Development;Diagnosis;Diagnostic;Diffusion;Diffusion Magnetic Resonance Imaging;diffusion weighted;Disease;Disease Progression;Early Diagnosis;Edema;efficacy evaluation;End stage renal failure;Endothelium;Epithelial Cells;Etiology;experience;Failure;feature selection;Fibrosis;Functional disorder;Goals;Histopathology;immune cell infiltrate;Immunosuppression;improved;Infection;Inflammation;Injury;Injury to Kidney;insight;inter-individual variation;interstitial;Kidney;kidney allograft;kidney biopsy;kidney dysfunction;Kidney Transplantation;Lesion;Living Donors;Longitudinal Studies;Machine Learning;machine learning model;macromolecule;Magnetic Resonance Imaging;Maps;Measurement;Measures;Methods;model building;Modeling;Modernization;Monitor;mortality;Motion;Nature;novel;novel therapeutics;Outcome;outcome prediction;Pathology;Pathway interactions;Patient Monitoring;patient population;Patient-Focused Outcomes;Patients;Performance;Perfusion;Phenotype;Physiological;post-transplant;predict clinical outcome;Prevalence;Process;prognostic;prognostication;Proteinuria;Protocols documentation;Reference Standards;Relaxation;renal damage;Reproducibility;Risk;RNA;Sampling Errors;secondary outcome;Severities;Staging;statistical and machine learning;Statistical Methods;Statistical Models;Structure;Techniques;Testing;Time;Tissue Sample;Tissues;Transplant Recipients;treatment choice;Treatment Efficacy;treatment optimization;treatment planning;Tubular formation;United States;urinary;Validation;virtual;Water

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Cerebrovascular;Conditions Affecting the Embryonic and Fetal Periods;Fetal Alcohol Spectrum Disorders (FASD);Intellectual and Developmental Disabilities (IDD);Natural Products;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Substance Misuse

ORG_CITY: COLLEGE STATION

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE Prenatal Alcohol Exposure (PAE) is the leading cause of neurodevelopmental disability in the US. However, the emerging practice of simultaneous alcohol and cannabinoid (SAC) use among young adults of child-bearing age makes it imperitive to investigate the additional risk for adverse infant outcomes due to such prenatal poly-substance use. The goals of this proposal are consistent with the priorities of the Collaborative Research on Addiction at NIH (CRAN) initiative, which are to, “address poly- or multiple substance use, abuse, and addiction” and to “elucidate the common, specific, and interacting causes and consequences of substance exposure”.

PI_NAMEs: LARIN, KIRILL V;MIRANDA, RAJESH C (contact)

PROGRAM_OFFICER_NAME: POWELL, ELIZABETH

PROJECT_TERMS: 3-Dimensional;Acute;addiction;Address;Adolescent;Adult;Age;Alcohol consumption;alcohol exposure;Alcohols;Anatomy;angiogenesis;Angiogenesis Inhibition;Behavior;Behavioral;Behavioral Assay;behavioral outcome;Biological Assay;Birth;Blood flow;blood vessel development;Brain;brain based;brain size;cannabinoid receptor;cannabinoid receptor antagonist;Cannabinoids;Cells;cerebrovascular;Cerebrovascular Circulation;child bearing;conditioned place preference;Consumption;craniofacial;Data;Defect;Development;Developmental Disabilities;disability;Dose;Drug usage;efficacy evaluation;Ethanol;Exposure to;fetal;Fetal alcohol effects;Fetal Alcohol Exposure;Fetal Development;Fetus;Goals;Growth;Histologic;Human;Hyperactivity;Impairment;in vivo;indexing;infant outcome;Ingestion;innovation;Intervention;Intoxication;Label;Legal;Light;Literature;malformation;marijuana legalization;marijuana use;Maternal Exposure;Mediating;Microscopy;Modeling;Molecular;Molecular Analysis;mouse model;multiple drug use;Mus;nerve stem cell;neural;Neurodevelopmental Disability;neurogenesis;neurovascular;novel;offspring;Optical Coherence Tomography;optical imaging;Outcome;Outcome Study;Pharmaceutical Preparations;pharmacologic;Placenta;polysubstance use;Positioning Attribute;preference;Pregnancy Outcome;prenatal;prevent;protective effect;psychologic;Public Policy;Publishing;Receptor Activation;Recreation;Reporter;Reporting;Research;Resolution;Risk;Risk Taking;Rodent;Second Pregnancy Trimester;Severities;Signal Pathway;Signal Transduction;synergism;synthetic cannabinoid;Teratogens;Testing;trend;Ultrasonography;United States National Institutes of Health;vasculogenesis;virtual;young adult;Zebrafish

PROJECT_TITLE: Prenatal alcohol/cannabinoid co-exposures and fetal brain development


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Depression;Mental Health;Neurosciences;Pediatric;Social Determinants of Health

ORG_CITY: STANFORD

ORG_DEPT: PSYCHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE Young adults face a striking levels of depression, anxiety, and loneliness, and though social factors—such as peer support—are likely pivotal to the mental health trajectories of young adults, existing work is limited in its ability to precisely quantify these long-term effects. This project will apply a unique combination of social network analysis, experience sampling, and neuroimaging in a large, longitudinal sample (two university cohorts) to examine (i) the formation of social communities among young adults, (ii) the effects of subjective, biological, and community-level indices of social connectedness on students’ mental health over their four-year college arc, and (iii) the role of relationships in sustaining well being during an acute, large-scale stressor—the COVID-19 pandemic. This work will sharpen basic science understanding of social factors in mental health, and pave the way for precise, novel interventions to bolster social connectedness and well being.

PI_NAMEs: ZAKI, JAMIL  (contact)

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Acute;Address;Affect;Affective;Anxiety;Articulation;Basic Science;behavior measurement;Biological;Brain;Brain imaging;burden of illness;career;Cognitive;cohort;college;Communities;COVID-19 pandemic;Data;Data Set;data-driven model;digital media;Distress;Down-Regulation;Ecological momentary assessment;emotion regulation;Emotions;Empathy;Exhibits;experience;Face;falls;follow-up;Fostering;Functional Magnetic Resonance Imaging;Goals;Grant;Health;Incidence;indexing;Individual;Interpersonal Relations;Intervention;Investigation;Life;Loneliness;Long-Term Effects;Maintenance;Maps;Measures;Mediating;Mental Depression;Mental Health;Microclimate;Modeling;Mood Disorders;negative affect;neural;neuroimaging;Neurosciences;novel;Outcome;pandemic disease;Participant;Pathway Analysis;peer;peer support;Personal Satisfaction;Persons;Play;Policies;Population;Positioning Attribute;pre-pandemic;predictive modeling;promote resilience;psychologic;Public Health;Recovery;recruit;Reporting;Research;Research Personnel;resilience;Resources;Role;Sampling;Scanning;social;Social Behavior;Social Distance;social factors;Social Interaction;Social Network;Social Psychology;Social support;Source;Stress;stress management;stressor;Students;Surveys;Symptoms;Testing;Time;tool;undergraduate student;Universities;university student;Work;young adult

PROJECT_TITLE: Social factors in the mental health of young adults: Bridging psychological and network analysis


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: Project Narrative: This proposal aims to understand how secretory and membrane proteins are properly synthesized and folded in the endoplasmic reticulum (ER). The ER-resident sensor molecules monitor and adjust the protein folding capacity of the ER according to demand. We previously discovered that one of the sensor molecules, IRE1, forms a direct complex with the protein translocation machinery in the ER. In this proposal, we will mechanistically understand how both IRE1 and protein translocation machinery work together to maintain ER homeostasis, which is fundamentally important for producing functional molecules, including antibodies, hormones, and transport proteins.

PI_NAMEs: MARIAPPAN, MALAIYALAM  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Address;Antibodies;Apoptotic;Architecture;ATP phosphohydrolase;Attenuated;Beta Cell;Biochemical;Biogenesis;Carrier Proteins;Cell Death;Cell Death Induction;Cells;Cessation of life;Chronic;Complex;CRISPR/Cas technology;Data;Defect;Degradation Pathway;Development;Diabetes Mellitus;Disease;Dominant-Negative Mutation;Endoplasmic Reticulum;endoplasmic reticulum stress;Enzymes;Funding;Genes;Homeostasis;Hormones;Human;human disease;insight;Knowledge;Lead;Life;Link;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Messenger RNA;misfolded protein;Molecular;Molecular Chaperones;Monitor;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Pathway interactions;Phosphorylation;Phosphotransferases;Physiological;Play;polycystic liver disease;polypeptide;prevent;protein folding;Protein translocation;Proteins;Quality Control;reconstitution;recruit;response;Ribonucleases;Ribosomes;RNA Splicing;Role;secretory protein;sensor;Signal Transduction;Structure;Testing;transcription factor;Ubiquitination;Work;XBP1 gene

PROJECT_TITLE: The interplay between the UPR and protein biogenesis at the ER

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative: Despite advances in HIV-1 therapeutics, there is a need for anti-retrovirals that prevent resistance and that can be formulated as long-acting drugs. Nearly all current drugs are targeted to viral proteins. This application seeks to delineate a new host-virus protein-protein interaction interface as a drug target and to develop novel, first-in-class, dual-acting drugs which can target both virus- host protein-protein and viral protein-viral RNA interactions. These drugs that potently inhibit HIV- 1 replication may not induce drug resistance due to the fact that host factor is essential for viral replication and the escape mutants are likely to be replication defective.

PI_NAMEs: KALPANA, GANJAM V (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Affect;Anti-HIV Agents;Anti-Retroviral Agents;Anti-viral Agents;Binding;Biological Assay;Birds;C-terminal;Cell Line;Cell Physiology;Cells;Charge;Collaborations;Complement;Complex;Data;Defect;design;Development;Docking;drug action;Drug resistance;Drug Targeting;Escape Mutant;Event;experimental study;Genetic;genetic analysis;genomic RNA;Goals;HIV;HIV-1;HIV-1 integrase;Impairment;improved;in vivo;Infection;inhibitor;inorganic phosphate;insight;Integrase;Integrase Inhibitors;Integration Host Factors;knock-down;Knowledge;Laboratories;Lead;Libraries;Ligands;Mediating;meter;mimicry;Molecular;Morphogenesis;Morphology;mutant;Mutation;Nature;new therapeutic target;novel;Nucleic Acids;particle;Peptides;peptidomimetics;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;pharmacophore;pleiotropism;Positioning Attribute;prevent;Production;Protein Engineering;protein protein interaction;Proteins;Reporter;Research;Resistance;Response Elements;RNA;RNA Binding;RNA-Protein Interaction;Role;screening;small molecule;SMARCB1 gene;Specificity;stapled peptide;Structure;Structure-Activity Relationship;Suppressor Genes;Surface;Testing;Therapeutic;Viral;Viral Proteins;Viral reservoir;viral RNA;Virion;virtual;Virus;virus host interaction;Virus Latency;Virus Replication;Work

PROJECT_TITLE: RNA-mimicry to guide the intra-cellular targeting of host virus protein and viral RNA-protein interactions to inhibit HIV replication.

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Bioengineering;Cancer;Networking and Information Technology R&D (NITRD)

PHR: In this project we are developing new ways to understand the mechanisms by which cells interpret, and in cancer misinterpret, the host of stimuli from outside and inside the cell that determine behavior. We are building molecules that can report, through light emission, the behavior of multiple key elements of the cellular “decision making circuits”, and in parallel developing new mathematical tools to interpret the output of these molecules, and to integrate this data into overall models that reveal information flow in the circuitry. We are also developing the ability to control one circuit component while watching the activity of another, enabling us to dissect out causal relationships within cellular circuits.

PI_NAMEs: DANUSER, GAUDENZ  (contact);HAHN, KLAUS M.

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Actomyosin;Acute;Address;Adhesions;Adopted;Adoption;analog;Architecture;Basic Science;Behavior;Binding;Biological;Biomedical Engineering;Biosensor;cancer therapy;Cell Adhesion;Cell Adhesion Molecules;cell behavior;cell motility;Cell Physiology;Cells;Communities;Complex;computer science;Computing Methodologies;control theory;Coupled;Cytoskeleton;Data;data integration;Decision Making;design;Disease;Dyes;econometrics;Elements;Engineering;Environment;Etiology;Event;Family;Feedback;Fiber;Fluorescence Resonance Energy Transfer;GTP Binding;Guanine;guanine analog;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;high dimensionality;Homeostasis;Image;Image Analysis;image processing;imaging approach;imaging science;interdisciplinary approach;Interdisciplinary Study;interest;Label;light emission;Machine Learning;Malignant Neoplasms;Maps;Marketing;mathematical methods;mathematical theory;Mathematics;Membrane;Methods;migration;Modeling;Modification;Molecular;Molecular Conformation;Morphogenesis;multiplexed imaging;Neighborhoods;novel;Oncogenic;optogenetics;Organic Chemistry;Output;Pathway interactions;Play;preservation;Process;Protein Engineering;Proteins;Proxy;Regression Analysis;Regulation;Reporting;Research;Research Project Grants;Resolution;response;rho;rho GTP-Binding Proteins;Role;Route;Series;Signal Pathway;Signal Transduction;Signal Transduction Pathway;single molecule;Site;spatiotemporal;Specific qualifier value;Specificity;Statistical Models;Stimulus;Structure;System;Techniques;Testing;Time;Time Series Analysis;tool;Translating;Translational Research;Visualization

PROJECT_TITLE: Integrated visualization, control, and analysis of GEF – GTPase networks in living cells

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]