NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Genetics;Infectious Diseases;Orphan Drug;Rare Diseases;Tuberculosis

ORG_CITY: EL PASO

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

PHR: PROJECT NARRATIVE Tuberculosis (TB) remains a global health problem with an estimated 10 million new infections and 1.2 million deaths per year despite existing effective chemotherapies that are long due to the presence of Mycobacterium tuberculosis (Mtb) subpopulation called “persisters”. We have discovered that arginine starvation leads to rapid sterilization of Mtb in vitro as well as in mice and, by using fragment-based drug design, we have identified two scaffold molecules that bind and inhibit the enzymatic activity of ArgB. This proposal seeks to optimize scaffold molecules to novel drugs that rapidly sterilize cultures of Mtb and expanding the drug target space by further validating other enzymes in the pathway as potential drug targets providing new drug possibilities and new insights to shorten TB chemotherapy and to treat Multidrug-resistant Mtb strains.

PI_NAMEs: TIWARI, SANGEETA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Age;Anabolism;Arginine;bactericide;Binding;Bypass;Cells;Cessation of life;Characteristics;chemotherapy;Combined Modality Therapy;cross reactivity;Cysteine;Drug Design;drug development;drug discovery;Drug resistance;Drug resistance in tuberculosis;Drug Screening;Drug Targeting;drug-sensitive;enzyme biosynthesis;enzyme pathway;Enzymes;extensive drug resistance;Extreme drug resistant tuberculosis;Gene Deletion;Genes;genetic signature;global health;Goals;Health;Homologous Gene;Human;Immune;improved;In Vitro;in vivo;Infection;insight;isoniazid;Isoniazid resistance;knock-down;Length;Libraries;Ligands;Macrophage;Mediating;metabolomics;Methionine;mouse model;Multi-Drug Resistance;Multidrug-Resistant Tuberculosis;Multiple drug resistant Mycobacteria Tuberculosis;Mus;mutant;Mycobacterium tuberculosis;N acetyl L glutamate;novel;novel therapeutics;Organism;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Play;Population;Process;promoter;Regimen;Reporter;Reporting;Research;Resistance;resistant strain;Resolution;Rifampin;Role;Route;scaffold;Starvation;Sterilization;Structure;Suppressor Mutations;System;Testing;Toxic effect;transcriptomics;Tuberculosis;tuberculosis chemotherapy;tuberculosis drugs;tuberculosis treatment;Work;World Health Organization

PROJECT_TITLE: Development of Drugs to Target Arginine Biosythesis in Mycobacterium tuberculosis


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences

ORG_CITY: JACKSONVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MAYO CLINIC  JACKSONVILLE

ORG_STATE: FL

PHR: PROJECT NARRATIVE In humans, risk factors for Alzheimer’s disease (AD) include aging and genetic risk factors implicated in altering brain inflammation and microglia, the resident immune cell of the brain, suggesting that factors that shape these responses can alter pathology. We have shown that CD8+ T cells increase in the CNS during the process of tauopathy or age-associated amyloidosis, lending evidence to an emerging idea that peripheral adaptive immune cells (i.e. CD4+T cells, CD8+ T cells, B cells) may also play a role in shaping central nervous system (CNS) pathology and microglial function. The goal of this proposal is to determine how CD8+ T cells impact cognition, neuroinflammation, gliosis, microglial transcriptomes and pathology observed during the process of age-associated amyloidosis or tauopathy, the two hallmark pathological features of AD, and define the transcriptomic profiles of CNS CD8+ T cells.

PI_NAMEs: COOK, CASEY N (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: adaptive immune response;Adaptive Immune System;adaptive immunity;Address;age related;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease risk;Amyloid beta-Protein Precursor;amyloid formation;amyloid pathology;Amyloidosis;Animals;Anti-Inflammatory Agents;Association Learning;Astrocytes;B-Lymphocytes;Behavior;Behavioral;Biological Assay;Blood - brain barrier anatomy;Brain;brain cell;CCL3 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Count;Cell Physiology;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Central Nervous System;Cognition;cognitive ability;Cognitive deficits;cognitive function;cognitive performance;conditioned fear;cytokine;Data;Dementia;Deposition;Disease;Disease Progression;Encephalitis;Epidemic;Excision;experimental study;Gene Expression;Gene Transfer Techniques;Genes;genetic risk factor;Gliosis;Goals;Granzyme;Hippocampus;Human;Human Amyloid Precursor Protein;Human Genetics;human tissue;Immune;Immune system;Immunity;Immunofluorescence Immunologic;in vivo;Inflammation;Inflammatory;insight;Interferon Type II;Kinetics;Knock-in Mouse;Knock-out;Life;Measures;Methodology;Microglia;Modeling;morris water maze;mouse model;Mus;Nerve Degeneration;nerve stem cell;Neurodegenerative Disorders;neurofibrillary tangle formation;Neurofibrillary Tangles;neuroinflammation;normal aging;novel;novel therapeutics;OVA-8;Ovalbumin;Pathologic;Pathology;Peptides;Peripheral;Play;Population;Process;Production;response;Risk Factors;RNA;Role;Senile Plaques;Sentinel;Shapes;single-cell RNA sequencing;stem cell proliferation;Stimulus;T-Cell Depletion;T-Cell Receptor;T-Lymphocyte;T-Lymphocyte Subsets;tau Proteins;tau-1;Tauopathies;Time;transcriptome;transcriptomic profiling;transcriptomics;Transgenic Animals;Transgenic Organisms;TREM2 gene;Variant;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: Impact of T cells on the CNS during aging and Alzheimer’s disease

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Genetics;Neurosciences

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PI_NAMEs: WORLEY, PAUL F (contact)

PROJECT_TERMS: Acceleration;Adult;age acceleration;age effect;age related;Age-associated memory impairment;aged;Aging;aging mechanism;Attention;Axon;Behavior;Biochemical;Biology;Brain;calmodulin-dependent protein kinase II;Cellular biology;Cellular Membrane;Cognition;Cognitive;Cognitive aging;cognitive performance;Collaborations;Confocal Microscopy;Dose;entorhinal cortex;Equilibrium;Excitatory Synapse;Exocytosis;experimental study;Extracellular Protein;Failure;Female;gain of function;Genes;hippocampal pyramidal neuron;Hippocampus;Homeostasis;Image;Immediate-Early Genes;Impaired cognition;Impairment;in vivo;Incidence;Injections;innovation;insight;Interneuron function;Interneurons;Interruption;intravenous administration;Label;Lateral;Levetiracetam;Light;Long-Evans Rats;loss of function;Maintenance;male;Measures;Mediating;Memory;Messenger RNA;Methods;MicroRNAs;Microscopy;Modeling;Modification;Molecular;mRNA Transcript Degradation;Neocortex;neuronal excitability;Neurons;Oligonucleotides;Parvalbumins;Peptide Hydrolases;Periodicity;Phase;Photons;Physiological Processes;presynaptic;Presynaptic Terminals;prevent;Process;Protein Analysis;protein expression;protein function;Proteins;Rattus;Regulation;resilience;Resolution;Role;Schedule;Site;Sleep;success;Synapses;synaptic function;System;Testing;Therapeutic;Time;tool;trafficking;transgene expression;Transgenes;translatable strategy;two-photon;Vesicle;Virus;Work

PROJECT_TITLE: PROJECT 4-NPTX2 and Adaptation to Cognitive Aging


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Drug Abuse (NIDA only);Mental Health;Neurosciences;Pediatric;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Social Determinants of Health;Substance Misuse;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: CHARLESTON

ORG_DEPT: PSYCHIATRY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The ABCD Study consortium uses multimodal brain imaging, cognitive and clinical assessments, bioassays, mobile monitoring, and careful assessment of substance use, environment, psychopathological symptoms, and social functioning in 11,878 9-10 year-olds to be followed over 10 years, to determine the effects of substance use on adolescent brain and cognitive development. This ABCD Research Project Site will follow and assess participants enrolled in the study. These data will be shared with the scientific community to address a comprehensive range of questions concerning youth development.

PI_NAMEs: GRAY, KEVIN M;SQUEGLIA, LINDSAY  (contact)

PROGRAM_OFFICER_NAME: DEEDS, BETHANY

PROJECT_TERMS: 10 year old;Address;Adolescence;Adolescent;adolescent substance use;Adult;adverse outcome;Affect;Age;Alcohol consumption;Alcohols;Anxiety;assessment application;Athletic Injuries;Behavior;Behavioral;Bioinformatics;Biological;Biological Assay;Biology;Brain;Brain imaging;Caffeine;Calendar;Cannabis;Child;Child Health;Childhood;Clinical assessments;Cognition;Cognitive;cognitive development;cognitive testing;cohort;college;Communities;Country;Data;Data Analyses;Decision Making;design;Development;emerging adult;Emotional;emotional factor;Enrollment;Ensure;Environment;Environmental Exposure;Environmental Risk Factor;Epidemiology;Ethics;Event;experience;Feeling suicidal;Female;follow-up;Funding;gene interaction;Genetic;Health;Impairment;Individual;Informatics;informatics infrastructure;Interview;Life;Link;Longitudinal Studies;marijuana use;Mental Depression;Mental disorders;Mental Health;Methodology;Methods;mobile application;mobile computing;Monitor;multimodality;neural;Neurocognition;Neurocognitive;neurodevelopment;neuroimaging;Neuropsychological Tests;novel;Occupations;Outcome;Parents;Participant;participant enrollment;participant retention;Pathway interactions;Persons;Physical activity;physical conditioning;Privatization;Process;Protocols documentation;Psychopathology;Qualifying;recruit;Recurrence;Registries;Research;research and development;Research Personnel;Research Project Grants;Resource Informatics;Resources;response;retention rate;Risk;Role;Sampling;Schools;Science;Secure;Severities;Siblings;Site;Sleep;sleep pattern;social;Social Functioning;Social isolation;social media;Specific qualifier value;Sports;Standardization;substance use;Symptoms;Technology;Teenagers;Telephone;temporal measurement;Text;Time;Tobacco;Tobacco use;Training;Traumatic Brain Injury;trend;Triplet Multiple Birth;tv watching;Twin Multiple Birth;United States;vaping;Video Games;young adult;Youth

PROJECT_TITLE: 13/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT MUSC


ADMINISTERING_IC: OD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: EUGENE

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE The Zebrafish International Resource Center 1) provides a central repository for zebrafish wild-type, transgenic, and mutated genetic stocks, and other research materials, 2) provides consultation and pathology services, and 3) researches and develops husbandry standards such as the composition of diets, nutrition requirements, and food management strategies that support ZIRC and research community husbandry goals. ZIRC materials, services, and husbandry and health standards will be made widely available to the research community.

PI_NAMEs: VARGA, ZOLTAN MARTON (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TITLE: Zebrafish International Resource Center (ZIRC)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V(55)R]


NIH_SPENDING_CATS: Genetics;Prevention

PROJECT_TITLE: Zebrafish International Resource Center, Resource Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-V]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Chronic Pain;Genetics;Pain Research;Pediatric;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Narrative Hereditary Multiple Exostoses (HME) is a potentially severe disorder that affects about 1 in 50,000 children and adolescents worldwide and is characterized by benign cartilage tumors called osteochondromas. HME is associated with growth retardation, skeletal deformities, chronic pain, limited mobility and fatigue, and is linked to life-threatening malignant transformation in about 2-3% of patients. There are no cures or effective treatments at the moment, and this project thus aims to further clarify the mechanisms of osteochondroma pathogenesis and test specific therapeutic treatments to prevent their formation and growth.

PI_NAMEs: PACIFICI, MAURIZIO  (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Ablation;Adolescent;Affect;Agonist;antagonist;Area;Automobile Driving;autosome;Benign;Biochemical;Biological;Biological Availability;Biomedical Research;Bioreactors;Blood Vessels;bone morphogenetic protein receptors;Bone Morphogenetic Proteins;burden of illness;cartilaginous;Cartilaginous exostosis;Cell Lineage;Cell Surface Receptors;Cells;Child;Childhood;Chondrogenesis;Chondrogenic Neoplasm;chronic pain;Clinical;Communities;Congenital Disorders;Data;Deformity;Development;Diffusion;Diphtheria Toxin;Disease;Disease Progression;Distal;Dose;effective therapy;Effectiveness;Enzymes;Epiphysial cartilage;Erinaceidae;Exostoses;EXT1 gene;EXT2 gene;Extravasation;Family;Family member;Fatigue;FDA approved;Funding;Genetic;Golgi Apparatus;Growth;Growth and Development function;Heparitin Sulfate;Hereditary Multiple Exostoses;Heterozygote;human disease;Impairment;Injections;insight;Left;Life;Link;Malignant - descriptor;Modality;Molecular;Monitor;mouse model;Mus;Mutant Strains Mice;Mutation;Nerve;Nerve compression syndrome;novel;Operative Surgical Procedures;osteogenic protein 2;Pain;parathyroid hormone-related protein;Pathogenesis;Pathogenicity;Pathology;Patients;Pattern;Pharmacotherapy;Phenotype;Population;prevent;Prevention;Process;progenitor;protein distribution;Proteins;Proteoglycan;receptor;Receptor Signaling;Regimen;Resected;Role;Safety;Severities;side effect;Signal Transduction;Signaling Protein;skeletal;skeletal stem cell;smoothened signaling pathway;Source;stem;Structure;Syndrome;Tamoxifen;Testing;Therapeutic;therapeutic target;therapeutically effective;Tissues;Transgenic Mice;translational medicine;tumor

PROJECT_TITLE: Pathogenic Mechanisms in Hereditary Multiple Exostoses Syndrome

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Human Genome;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Genome-wide association studies (GWAS) have been extremely successful in mapping genetic determinants of common disease and traits, however, they do not identify the causal variants and genes per se, and a large fraction of heritable risk/variation remains unmapped. Our proposed studies are based on the hypotheses that a) common sequence variation in specific cis-regulatory elements (CREs) influence expression of specific genes and, thereby, underlie disease risk or trait variation, and b) genes underlying diseases and traits are often functionally related and expressions of functionally related genes are often co-regulated. In this proposal, we develop strategies to identify specific CRE variants and causal genes at mapped electrocardiographic QT interval GWAS loci, and to uncover additional, yet unmapped QT interval genes through regulatory networks, and expect the knowledge gained to have a significant contribution to genetics of QT interval variation and sudden cardiac death risk.

PI_NAMEs: KAPOOR, ASHISH  (contact)

PROGRAM_OFFICER_NAME: BURNS, KRISTIN

PROJECT_TERMS: Action Potentials;Adult;Affect;Alleles;Arrhythmia;base;Binding;Biological Assay;candidate identification;Cardiac;Cardiac Myocytes;causal variant;Cells;Chromatin;Chromosome Mapping;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communities;Complex;Coupling;Dependence;differential expression;Disease;disorder risk;Down-Regulation;Electrocardiogram;Electrophysiology (science);Elements;Embryo;Enhancers;epigenomics;gene discovery;Gene Expression;gene regulatory network;General Population;Genes;Genetic;Genetic Determinism;Genetic Polymorphism;Genetic study;genome wide association study;Heritability;Heritable Quantitative Trait;Human;human induced pluripotent stem cells;in silico;in vivo;indexing;induced pluripotent stem cell derived cardiomyocytes;Ion Channel Gating;Knowledge;Lead;Left ventricular structure;Linear Regressions;Link;Luciferases;Maps;member;Modeling;Molecular;Molecular Genetics;mortality risk;Mus;Muscle Cells;Mutation;Neonatal;Penetrance;Population;Prevalence;Proteins;Quantitative Trait Loci;Rattus;Regulation;Regulatory Element;Reporter;Resources;Risk;Short QT syndrome;Signal Transduction;Site;sudden cardiac death;Testing;Tissues;trait;transcription factor;transcriptome;transcriptome sequencing;Untranslated RNA;Up-Regulation;Variant;Ventricular;voltage;Zebrafish

PROJECT_TITLE: Identifying Cis-Regulatory Variants, Genes, and Regulatory Networks Underlying QT Interval Variation

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: Portland

ORG_NAME: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER

PHR: PROJECT NARRATIVE Powerful memories are associated with drug-taking behavior over extended periods, and these memories drive relapse to drugs of abuse. We will use a well-established rodent model of cocaine addiction to identify how the prefrontal cortex and associated circuits can be modified to reduce cocaine relapse. These studies have translational potential in humans because disruption of cocaine-related memories is expected to help break the cycle of relapse.

PI_NAMEs: AICHER, SUE A;BROWN, TRAVIS EUGENE;IMPEY, SOREN ;SORG, BARBARA A (contact)

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Animals;Antibodies;Behavior;Binding;Brain;Brain region;Calcium;Cell Physiology;Cells;Chondroitin ABC Lyase;Cocaine;cocaine cue;Cocaine Dependence;cocaine relapse;cocaine seeking;cocaine self-administration;cocaine use;Cocaine use disorder;Communication;conditioned place preference;Coupling;Cues;Data;designer receptors exclusively activated by designer drugs;Drug Controls;drug of abuse;drug relapse;drug seeking behavior;Electrophysiology (science);Equilibrium;Excision;experimental study;Extracellular Matrix;FDA approved;genetic approach;Glutamates;Goals;hippocampal pyramidal neuron;Hippocampus;Homeobox;Human;Immunohistochemistry;Impairment;in vivo;Individual;innovation;insight;Intake;Interneurons;Ion Channel;Knock-in;Link;Measures;Medial;Mediating;Memory;memory consolidation;memory retrieval;Messenger RNA;Modeling;Modification;Molecular;Neurons;novel;Output;Parvalbumins;Pathway interactions;Pattern;Permeability;Pharmaceutical Preparations;Prefrontal Cortex;Prevalence;prevent;Publishing;Pyramidal Cells;Rattus;recruit;Relapse;Resistance;response;Rodent;Rodent Model;Self Administration;Slice;Source;Structure;Synapses;Techniques;Testing;Tracer;transcriptomics;Translating;translational potential;Work

PROJECT_TITLE: Cocaine, Parvalbumin, and Perineuronal Nets

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Nutrition

PROJECT_TITLE: Zebrafish International Resource Center, Applied Research Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Mental Health;Mental Illness;Prevention;Serious Mental Illness

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Approximately one in two individuals with bipolar disorder (BD) are non-adherent with medication, often leading to severe and negative consequences. Unfortunately,there is no widely used evidence -based approach to target poor adherence among individuals with BD. Building upon positive efficacy trial r esults, the proposed project will test the effectiveness of technology-facilitated Customized Adherence Enhancement (CAE) vs. enhanced treatment as usual (eTAU) using a prospective randomized controlled design in public mental health care settings and preferentially enrolling poorly adherent/high-risk individuals with BD. Deliverables include a curriculum-driven adherence enhancement approach that can be implemented in public healthcare settings and which can improve outcomes for the most vulnerable groups of people with BD.

PI_NAMEs: LEVIN, JENNIFER BETH;SAJATOVIC, MARTHA X (contact)

PROGRAM_OFFICER_NAME: DAVIS, BESHAUN JAMAAL

PROJECT_TERMS: Academic Medical Centers;Adherence;Administrator;Anticonvulsants;Antipsychotic Agents;Area;Bipolar Disorder;Caring;Characteristics;Clinic;Clinical;Communities;Corrosives;cost;County;design;Education;Educational Curriculum;Effectiveness;effectiveness testing;effectiveness/implementation hybrid;efficacy trial;Elements;Emergency department visit;Enrollment;Environment;Evaluation;Event;evidence base;Family;family support;flexibility;functional improvement;functional status;Future;Generations;Goals;Guidelines;health care settings;Health Promotion;Health Resources;Healthcare Systems;high risk;high risk population;Hospitalization;implementation facilitators;implementation intervention;improved;improved outcome;Individual;individual patient;innovation;Internet;Intervention;Intervention Studies;Life;Lithium;Mediating;medication compliance;Mental Health;Mental Health Services;Modeling;Moods;Outcome;Outpatients;Patient Compliance;Patients;Persons;Pharmaceutical Preparations;Prevention;programs;Promoting Action on Research Implementation in Health Services framework;prospective;Provider;psychiatric comorbidity;Public Health;Public Sector;Qualitative Methods;Randomized;randomized controlled design;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Recovery;Regimen;Relapse;Reporting;response;Review Literature;safety net;scale up;Site;suicide rate;System;Technology;Testing;Text Messaging;treatment as usual;treatment effect;United States Department of Veterans Affairs;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Effectiveness RCT of Customized Adherence Enhancement

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Colorectal Cancer;Digestive Diseases

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: Project Narrative: This proposal aims to define the role of the CCR6/CCL20 axis on the chemotherapeutic response in colon cancer. Develop combination to improve therapeutic outcome, reduce toxicity that limits optimal use of conventional treatments, and offer a better quality of life to colon cancer patients.

PI_NAMEs: MIR, HINA ABDULREHMAN (contact)

PROJECT_TERMS: Apoptosis;Apoptotic;beta catenin;beta-Chemokines;Bioinformatics;Biological;Biology;Biometry;Blood;Blood Chemical Analysis;cancer cell;Cancer Etiology;Cancer Model;CCL20 gene;Cell Cycle;Cell Line;Cessation of life;chemokine;chemokine receptor;Chemoresistance;chemotherapy;Clinic;Clinical;colon cancer patients;colon cancer treatment;Colon Carcinoma;Combined Modality Therapy;Control Groups;conventional therapy;cytokine;cytotoxic;cytotoxicity;Data;Databases;design;Disease;Dose;E-Cadherin;efficacious treatment;efficacy evaluation;Enzyme-Linked Immunosorbent Assay;epithelial to mesenchymal transition;Fluorouracil;Genomics;Goals;Hepatotoxicity;Human;immunodeficiency;improved;In Vitro;in vivo;indexing;ineffective therapies;innovation;Invaded;Investigation;Kidney;Ligands;Luciferases;Macrophage;Maximum Tolerated Dose;Mediating;Mesenchymal;migration;Modality;Modeling;Molecular;molecular phenotype;Molecular Target;mouse model;Mus;neoplastic cell;Normal Cell;novel;novel strategies;Organ;Outcome;oxaliplatin;Pathology;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;pre-clinical;Pre-Clinical Model;Proliferating;prospective;Proteomics;Publications;Publishing;Quality of life;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance development;response;RNA Interference;Role;Sampling;screening;Serum;Signal Transduction;small molecule inhibitor;Snails;Spleen;stemness;Testing;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapy outcome;Tissues;Toxic effect;transcriptomic profiling;Treatment Efficacy;treatment group;treatment response;Treatment-related toxicity;tumor;Tumor Immunity;Tumor Volume;tumor xenograft;Tumor-infiltrating immune cells;United States;Vimentin;Xenograft procedure

PROJECT_TITLE: Role of CCR6-CCL20 in biology and chemotherapeutic response in colon cancer


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Digestive Diseases;Immunization;Infectious Diseases;Liver Disease;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: ROCKVILLE

ORG_NAME: SANARIA, INC.

PHR: PROJECT NARRATIVE Malaria affects over two billion people, killing over 400,000 individuals each year mostly children in Africa. A powerful tool is needed for eliminating Plasmodium falciparum malaria from defined geographical areas. The ideal tool would be a highly effective, long-acting vaccine that prevents infection, and thereby disease and parasite transmission. There is currently no alternative to clinical trials for demonstrating that a vaccine candidate exhibits performance superior to current SPZ vaccines Therefore, in this project we will develop in vitro assays and/or non-human primate (NHP) models that indicate if a human will be protected against Pf infection by a SPZ vaccine, and use them to show superiority of new SPZ vaccines.

PI_NAMEs: HOFFMAN, STEPHEN LEV (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Affect;Africa;Amino Acids;Animal Model;Animals;Antibodies;Antigens;Aotus primate;Area;asexual;Attenuated;attenuation;Binding;Biological Assay;Biological Markers;Biological Models;Blood;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Separation;Cells;Child;Clinical Trials;cost;Cytoprotection;Data;Development;Disease;Dose;Erythrocytes;Europe;Exhibits;Falciparum Malaria;Geographic Locations;Germany;Glean;Goals;Hepatocyte;Human;Immune response;Immunity;Immunization;Immunize;Immunologics;improved;in vitro Assay;in vivo;Individual;Infection;Infection prevention;Interferons;Interleukin-12;intravenous administration;Learning;Licensing;Liver;lymph nodes;Macaca mulatta;Machine Learning;Malaria;Measures;Mediating;Methods;Modeling;Mus;next generation;Nitric Oxide;nonhuman primate;Organ;Parasites;Peptides;Performance;Peripheral Blood Mononuclear Cell;Persons;Phase;Plasma;Plasmodium falciparum;Plasmodium falciparum vaccine;predictive test;Process;Production;prospective;protective efficacy;Proteins;Radiation;Regimen;research clinical testing;response;Safety;Seminal;Serum;Spleen;Sporozoite vaccine;Sporozoites;Statistical Models;subcutaneous;success;Surface;Systems Biology;T cell response;T-Lymphocyte;Testing;tissue biomarkers;Tissues;tool;Transcript;transmission process;vaccine candidate;vaccine efficacy;vaccine-induced immunity;Vaccines;volunteer;Work

PROJECT_TITLE: Development of Non-Human Primate Models to Assess Immunological Mechanisms and Antigenic Targets of Protective Sporozoite (SPZ) Vaccines and Establish Superior Efficacy of Next Generation SPZ vaccines


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Neurosciences;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Co-use of tobacco and cannabis has been increasing, especially among young adults. Recent changes in the popularity of electronic nicotine delivery systems (ENDS) as well as in the growing number of states legalizing recreational cannabis use increase the public health concern related to the upsurge in co-use. The overall goal of this study is to examine the situational, momentary factors associated with the different patterns of tobacco and cannabis co-use, how they may vary by delivery mode, and how they are associated with changes in behavioral outcomes (e.g., dependence, changes in rates of use, problem behaviors) – data which will be helpful for informing prevention, intervention, and policy approaches to reduce harm from both products.

PI_NAMEs: MERMELSTEIN, ROBIN J. (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Address;Affective;aged;Alcohol consumption;Behavior;Behavioral;behavioral outcome;Cannabis;cannabis use behavior;Characteristics;Cognition;Cognitive;Consumption;Data;Data Collection;Dependence;Devices;Ecological momentary assessment;electronic liquid;Electronic Nicotine Delivery Systems;Enrollment;experience;Failure;Future;Gender;Goals;Harm Reduction;Health;Hour;Illinois;inclusion criteria;Individual;Individual Differences;Intervention;Knowledge;Legal;Location;marijuana use;Methodology;Methods;Moods;negative mood;Neurocognitive;Nicotine;non-cigarette tobacco product;Outcome;Participant;Pattern;Performance;Persons;Policies;positive mood;Prevention;Probability;Problem behavior;psychosocial outcome;Public Health;Reaction;Recreation;Reporting;Research;response;Risk Factors;Sampling;Short-Term Memory;Smoking;social;Social Environment;substance use;success;Surveys;Time;Tobacco;tobacco products;Tobacco use;tobacco user;vaping;Vaporizer;Work;young adult

PROJECT_TITLE: Context, Subjective and Cognitive Experiences with Patterns of Tobacco and Cannabis Co-Use in Young Adults

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Nutrition;Obesity

PHR: Project Narrative One major reason for the current obesity epidemic and its associated lack of effective treatment is due to incomplete understanding of neuronal control of complex feeding behavior. Using a combination of optogenetic and mouse genetic approaches, the current proposal will define a novel neural pathway from melancortin receptor 4-expressing neurons in the paraventricular nucleus of the hypothalamus (PVH) to Leptin receptor expressing neurons in the lateral septum neurons that regulates feeding through a glutamatergic monosysnpatic projection. The results will identify a previously unknown circuit that are critical for feeding regulation and therefore form a foundation for effective treatments for aberrant feeding behaviors and obesity.

PI_NAMEs: TONG, QINGCHUN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: adenovirus mediated delivery;Aggressive behavior;agouti protein;antagonist;Anxiety;associated symptom;Body Weight;Brain region;Brain Stem;Chronic;Complex;Data;design;designer receptors exclusively activated by designer drugs;diencephalon;effective therapy;Emotions;Energy Metabolism;Excitatory Amino Acid Antagonists;feeding;Feeding behaviors;Fiber;Foundations;Functional disorder;genetic approach;Glutamate Receptor;Glutamates;Goals;Homeostasis;Hormones;Human;Hyperphagia;Hypothalamic structure;in vivo;Infusion procedures;Lateral;leptin receptor;Light;LoxP-flanked allele;Mediating;Melanocortin 4 Receptor;midbrain central gray substance;mouse genetics;Mus;Mutation;Neural Pathways;Neurons;novel;Obesity;obesity development;Obesity Epidemic;optogenetics;parabrachial nucleus;paraventricular nucleus;Pharmaceutical Preparations;prodynorphin;Prosencephalon;Proteins;Psychiatry;receptor;Regulation;Research;Role;Satiation;side effect;Site;Stress;Synapses;Testing;Thalamic structure;Therapeutic;therapeutic development;Thyroxine;vector;vesicular glutamate transporter 2;Viral

PROJECT_TITLE: A novel MC4R neural pathway in feeding

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: WALTHAM

ORG_DEPT: CHEMISTRY

ORG_NAME: BRANDEIS UNIVERSITY

ORG_STATE: MA

PHR: Project Narrative The protein on the surface of the HIV virus is coated with a dense network of carbohydrates. Some of the best antibodies generated in natural HIV infection bind to these carbohydrates, but such antibodies normally arise too late to eliminate the infection, if they arise at all. This project will develop synthetic, stabilized variants of these carbohydrates, which will be tested as vaccines to stimulate carbohydrate- binding antibodies that may protect against HIV.

PI_NAMEs: KRAUSS, ISAAC JONATHAN (contact)

PROGRAM_OFFICER_NAME: MALASPINA, ANGELA

PROJECT_TERMS: Affinity;analog;Antibodies;Antibody Response;Antigens;arm;Binding;Carbohydrates;Carrier Proteins;Collaborations;cross reacting material 197;Disaccharides;Enzyme-Linked Immunosorbent Assay;Epitopes;Family;Family member;Glycoconjugates;Glycopeptides;glycosylation;Goals;HIV;HIV Antibodies;HIV Envelope Protein gp120;HIV Infections;Hydrophobicity;Immunization;Immunize;immunogenicity;improved;in vivo;Infection;Laboratories;Length;Macaca mulatta;man;Mannose;Mannosidase;mannosyl(9)-N-acetylglucosamine2;Memory B-Lymphocyte;Methods;Modification;neutralizing antibody;Oryctolagus cuniculus;Oxygen;Patients;Peptides;Polysaccharides;prevent;Proteins;response;Serum;Structure;Structure of germinal center of lymph node;Sulfur;Surface;Testing;V3 Loop;Vaccination;Vaccines;Variant;Virus;X-Ray Crystallography

PROJECT_TITLE: Mannosidase-stabilized glycan immunogens for elicitation of high mannose patch antibodies

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Lung;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Breast cancer is the leading cancer in women and claims about 40,000 lives in the United States every year. Metastasis account for 90% of breast cancer deaths. In order to develop effective treatments against cancer, we need to better understand the cellular and molecular mechanism underlying metastasis. Using clinical specimens, patient-derived xenograft models, and other cell line and models along with cutting-edge technology, this project aims to identify a novel mechanism critical for circulating tumor cell cluster formation and targeting strategies to block metastasis, thereby eventually contributing to a reduced mortality rate of breast cancer.

PI_NAMEs: LIU, HUIPING  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 4T1;Antibodies;Binding;Biochemical;Bioinformatics;Blocking Antibodies;Blood Vessels;Breast;breast cancer metastasis;Breast Oncology;Cancer Patient;CD44 gene;CDKN1A gene;Cell Aggregation;Cell Line;Cell model;Cell Survival;Cells;Cessation of life;Circulation;Clinical;Data;Death Rate;Down-Regulation;effective therapy;Extracellular Domain;Genes;Goals;Human;human model;Image;In Vitro;in vivo;Individual;inhibitor;lung colonization;lung tumorigenesis;Machine Learning;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mammospheres;MDA MB 231;Mediating;member;Metastatic Neoplasm to the Lung;Methods;migration;Modeling;Molecular;mouse model;Mus;Mutagenesis;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutics;Oncologist;overexpression;Pathway interactions;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Phenotype;Phosphotransferases;preclinical study;prevent;Prognosis;Property;Proteins;Research Design;Role;Signaling Protein;small molecule inhibitor;Specimen;stemness;Structural Biologist;Technology;Testing;Texas;Therapeutic;therapeutic development;triple-negative invasive breast carcinoma;tumor;Tumor Cell Line;tumor initiation;Tumor Promotion;tumorigenesis;tumorigenic;United States;Universities;Woman

PROJECT_TITLE: Molecular mechanisms underlying circulating tumor cell aggregation

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Over 850 million people suffer from some form of proteinuric kidney disease worldwide, which is more than double the number of diabetics, but current drugs remain woefully inadequate in preventing the resulting progressive loss of kidney function. Proteinuria is caused by diseases that impair the normal function of kidney podocytes thus disrupting the kidney filtration barrier leading to protein loss in urine, but how podocyte function is impaired at the structural level is unclear. In preliminary studies, we show that activation of a specific podocyte receptor by disease elicits maladaptive changes in podocytes, which we propose to define at the atomic structure level and aim to effectively prevent in preclinical studies using novel inhibitors of this receptor.

PI_NAMEs: ARNAOUT, M. AMIN  (contact)

PROGRAM_OFFICER_NAME: KETCHUM, CHRISTIAN J

PROJECT_TERMS: Address;Agonist;Albuminuria;antagonist;Attenuated;Binding;Biochemical;Blood;Blood capillaries;Cells;Chemicals;Chronic;Cilengitide;Complex;Cryoelectron Microscopy;Data;Development;diabetic;Disease;disease model;Experimental Animal Model;extracellular;Filtration;Focal and Segmental Glomerulosclerosis;Foot Process;FVB Mouse;Genetic;glomerular basement membrane;glomerular filtration;glomerular function;Grant;Growth Factor;Homeostasis;Human;Impairment;In Vitro;Inflammation Mediators;Inflammatory;inhibitor;Injury;Insulin-Dependent Diabetes Mellitus;Integrin alpha3;Integrin alpha3beta1;Integrin alphaVbeta3;Integrins;ITGB3 gene;Kidney;Kidney Diseases;Knock-out;Laminin;Laminin Receptor;Lead;Ligand Binding;Ligands;Lipopolysaccharides;Maintenance;Mechanics;Modeling;Molecular Conformation;Morphology;Mus;Mutation;Nonsense Mutation;novel;osteopontin;Pathogenesis;Pathologic;Persons;Pharmaceutical Preparations;pharmacologic;Physiological;Play;podocyte;preclinical study;Predisposition;pressure;prevent;Process;Proteins;Proteinuria;Rattus;receptor;Renal function;Resistance;Resolution;response to injury;Rodent Model;Role;shear stress;Site;Stimulus;Structure;Testing;Urine;Vitronectin

PROJECT_TITLE: Structure and Function of Integrins in the Kidney

STUDY_SECTION: KMBD

STUDY_SECTION_NAME: Kidney Molecular Biology and Genitourinary Organ Development[KMBD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Despite dramatic improvements in outcome for children with acute lymphoblastic leukemia (ALL), a significant number of children and more adolescents/young adults fail frontline therapy and their prognosis is dismal. While patients with prolonged remission have a better prognosis, most eventually succumb to their disease due to the emergence of resistant clones, despite increased intensity of frontline therapies. In this study, we will investigate how the reorganization of 3D chromatin architecture contributes to transformation and patients’ relapse in the most common form of ALL, B ALL.

PI_NAMEs: CARROLL, WILLIAM L. (contact);LIONNET, TIMOTHEE ;TSIRIGOS, ARISTOTELIS

PROGRAM_OFFICER_NAME: HENDERSON, LORI A

PROJECT_TERMS: 3-Dimensional;Acute leukemia;acute leukemia cell;Acute Lymphocytic Leukemia;Address;Adolescent;Affect;Architecture;Automobile Driving;B-Lymphocytes;Biology;Cancer Etiology;Cancer Patient;Cell Line;Cell Maintenance;Cells;cellular imaging;Child;childhood cancer mortality;Childhood Leukemia;Chromatin;Chromatin Loop;chromosome conformation capture;Chromosomes;Clinical;clinical phenotype;Clonal Evolution;cohort;computational pipelines;conventional therapy;Data;Diagnosis;Disease;Disease Progression;Disease remission;DNA;DNA Sequence Alteration;effective therapy;Enhancers;Ensure;Epigenetic Process;epigenome;Event;Evolution;Exhibits;experience;experimental study;Fishes;Gene Expression;Gene Expression Regulation;Genetic;genetically modified cells;Genome;genome-wide;Genomics;Growth;Hematologic Neoplasms;Heterogeneity;Imaging Techniques;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Infant;insight;Laboratories;Large-Scale Sequencing;Lesion;leukemia;leukemic transformation;Maintenance;Malignant Neoplasms;Maps;Measures;Mediating;Methodology;Modeling;Modification;Molecular Conformation;mortality;Mutation;Neighborhoods;novel;Outcome;patient derived xenograft model;Patients;Pharmacotherapy;Play;Population;Pre-Clinical Model;precursor cell;Process;Prognosis;promoter;Relapse;relapse patients;Resistance;Resolution;response;RNA;Role;Sampling;side effect;single molecule;Structure;Subgroup;Techniques;Technology;Therapeutic;translational impact;treatment response;tumor;tumor progression;Variant;Work;young adult

PROJECT_TITLE: Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcome

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Aphasia;Brain Disorders;Pediatric

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: The goal of this project is to provide better ways of understanding relations between the different domains or levels of language in language disorders and language development. To do this, we will provide complete phonological and fluency annotations of 200 transcripts taken from the databases for aphasia, dementia, child language disorders, and childhood disfluency. We will improve the capacity of the Phon program and the TalkBankDB database search system to operate with data across these different data types. This will allow us to conduct analyses of patterns that consider relations between the different language domains of phonology, fluency, lexicon, grammar, and discourse. These patterns will also be captured through analyses that seek to align the profiles of individual participants with comparison groups from the larger database.

PI_NAMEs: MACWHINNEY, BRIAN  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Achievement;Address;Aphasia;Attention;Characteristics;Child Language;Childhood;Clinical;clinically relevant;Code;comparison group;Data;data repository;Data Set;Databases;Dementia;Development;Disease;Disfluent;Educational workshop;Funding;Goals;improved;Individual;interoperability;Language;Language Development;Language Disorders;lexical;Linguistics;Link;Manuals;Methods;Morphology;online tutorial;Participant;Pattern;phonology;programs;symposium;System;tool;Transcript;United States National Institutes of Health;Work

PROJECT_TITLE: PhonBank integration within TalkBank: Acquisition, disorders, dysfluencies and paraphasias

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ORG_CITY: MIAMI

ORG_NAME: FLORIDA INTERNATIONAL UNIVERSITY

PI_NAMEs: GONZALEZ, RAUL  (contact);LAIRD, ANGELA R

PROJECT_TITLE: 4/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT FIU


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Health Services;Patient Safety;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Rehabilitation;Telehealth

ORG_CITY: Springfield

ORG_NAME: OREGON RESEARCH INSTITUTE

PHR: Project Narrative Currently, there are limited home-based exercise fall prevention interventions, especially those built on scientific evidence, available for broad dissemination to community-dwelling older adults who are at high risk for falls. This project evaluates an evidence-based tai ji quan intervention that is delivered in a home setting via videoconference technology. The intervention is intended to help older adults reduce falls and improve physical and cognitive function, and the results from this study will inform alternative preventative strategies for utilization of evidence-based fall prevention interventions in clinical and community settings.

PI_NAMEs: LI, FUZHONG  (contact)

PROGRAM_OFFICER_NAME: NELLISSERY, MAGGIE JACOB

PROJECT_TERMS: Address;Adoption;Adult;aging population;American;Behavior;Binding;Cessation of life;Clinical;clinical care;Clinical Practice Guideline;clinically relevant;cognitive function;cognitive performance;Communication;Communities;Community Health Services;Community Healthcare;community living;community setting;comparative effectiveness;cost;cost effective;Country;COVID-19 pandemic;Data;Dissemination and Implementation;Economic Burden;effective intervention;Effectiveness;effectiveness evaluation;Equilibrium;Evaluation;evidence base;executive function;Exercise;exercise intervention;exercise program;Fall prevention;fall risk;falls;flexibility;follow-up;Geography;Goals;Healthcare Systems;high risk;Home;human old age (65+);implementation barriers;implementation research;implementation strategy;improved;Incidence;Injury;innovation;instructor;Intervention;intervention program;Life;Mediator;mode of exercise;Morbidity - disease rate;mortality;multi-component intervention;multimodality;novel;novel strategies;older adult;Participant;Persons;Physical Function;Physical Performance;post intervention;Prevention strategy;preventive intervention;primary outcome;programs;Public Health;Randomized;Randomized, Controlled Trials;remote delivery;Research;Resources;response;Risk;Schedule;secondary outcome;social;Social Environment;social media;success;Tai Ji;Target Populations;Task Performances;Technology;Testing;Time;Training;Transportation;Treatment Efficacy;videoconference;Videoconferencing;virtual;walking performance;Work

PROJECT_TITLE: A Remotely Delivered Tai Ji Quan Intervention to Reduce Incidence of Falls in High Risk Community-Dwelling Older Adults

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MEMPHIS

ORG_NAME: MEMPHIS VA MEDICAL CENTER

ORG_STATE: TN

PHR: Post-traumatic osteoarthritis can result from a single or repetitive injury and is a major cause of disability in younger individuals as well as a major concern for Veterans who are at an increased risk from this condition. Currently, there is no effective treatment for this disease. Regenerative medicine therapies involving reparative cells, such as stem cells, reveal promising evidence in healing osteoarthritic lesions. Following transplantation, stem cells face several stress factors such as inflammatory mediators and oxygen-free radicals. This environment induces cell death and apoptosis after transplantation. We propose a hypothesis that a two-step anti-inflammatory and antioxidant-nanosome treatment strategy can improve the toxic micro- environment of the arthritic knee joint by delivering TPCA1-nanosome, and also prolong the ASCs’ viability to obtain enough time to survive by their immune-suppressive activity. We will use this interventional approach for the treatment of the knee in a PTOA animal model for pre-clinical translational research for patients.

PI_NAMEs: CHO, HONGSIK JAKE (contact)

PROJECT_TERMS: adipose derived stem cell;Adipose tissue;Age;Aging;Animal Model;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Area;Arthritis;Behavior;Binding;Biomechanics;bone;Cartilage;cartilage degradation;Cell Count;Cell Death Induction;cell injury;Cell surface;Cell Survival;Cell Therapy;Cell Transplantation;Cells;Cessation of life;Chondrocytes;chondroprotection;Clinical;clinical application;Coculture Techniques;combat;cytokine;Cytoprotection;Data;Degenerative polyarthritis;design;disability;Disease;Dose;effective therapy;Encapsulated;endogenous stem cells;Engineering;Environment;Etiology;Exhibits;Extracellular Matrix Degradation;Face;Fat-Soluble Vitamin;free radical oxygen;functional outcomes;Future;Goals;Growth;healing;Homing;Hydrophobic Interactions;immunogenicity;Immunosuppression;implantation;improved;In Vitro;in vitro Model;in vivo;Individual;Inflammation;Inflammation Mediators;Inflammatory;inflammatory milieu;inhibitor;Injectable;Injections;Injury;innovation;Intervention;joint inflammation;joint injury;joint stress;Joints;Knee;Knee Injuries;Knee joint;Knee Osteoarthritis;Lesion;Lifting;Lipids;lipofection;Matrix Metalloproteinases;mechanical load;Mechanical Stress;Mechanics;Mediating;Mesenchymal Stem Cells;Methods;military veteran;Modeling;Molecular;mouse model;Mus;nanoparticle;Natural regeneration;Occupational;Occupations;old mice;Operative Surgical Procedures;Oxidative Stress;Pain;Patient Recruitments;Patients;personalized approach;Pre-Clinical Model;preconditioning;Procedures;Property;Protocols documentation;Recovery;Regenerative Medicine;repaired;Reporting;Resistance;response;Risk;Route;Sex Differences;Sports;statistics;stem cell therapy;Stem cell transplant;stem cells;Stress;subchondral bone;success;System;targeted delivery;Technology;Therapeutic;Therapeutic Agents;Therapeutic Effect;Time;Tissues;Training;Translational Research;transmission process;Transplantation;Traumatic Arthropathy;Traumatic injury;Treatment Efficacy;Treatment Step;treatment strategy;Veterans;Vitamin E

PROJECT_TITLE: An Innovative Two-Step Therapeutic Strategy to Maximize the Effect of Stem Cell Therapy for Post-Traumatic Osteoarthritis

STUDY_SECTION_NAME: Regenerative Rehabilitation[RRD0]


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

ORG_STATE: CA

PHR: Methods for producing reagents specifically for glycan-protein crosslinking are developed. They are further used on live cells to characterize the fundamental nature of glycan-protein interactions on cell membrane. 1

PI_NAMEs: LEBRILLA, CARLITO B (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Affect;Amines;amino group;analytical method;Biology;cell behavior;Cell Line;Cell membrane;Cell Physiology;Cell Separation;Cells;Cellular Metabolic Process;Characteristics;Chemicals;Chemistry;Complex;covalent bond;Cross-Linking Reagents;crosslink;Crosslinker;Data Analyses;Development;Digestion;Environment;experimental study;fucose-binding protein;Glycopeptides;Glycoproteins;glycoproteomics;Individual;interest;Length;liquid chromatography mass spectrometry;Lysine;Mediating;Membrane Proteins;Metabolic Pathway;Methodology;Methods;Molecular;Monitor;Monosaccharides;Nature;Peptide Hydrolases;Peptides;Play;polypeptide;Polysaccharides;preservation;Procedures;protein complex;protein crosslink;Protein Glycosylation;protein protein interaction;Proteins;Proteomics;Reaction;Reagent;Research;Role;Sialic Acids;Site;Structure;Technology;Tissues;tool;Validation;Vertebral column

PROJECT_TITLE: Methods for crosslinking glycan-protein interactions in cell membrane

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: EB

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: NARRATIVE Empowering biomedical engineers to be open-ended problem solvers will impact technology advancement in healthcare. However, the necessary skill development and exposure to clinical problems is often not consistent enough in undergraduate curriculums. The overall objective of this proposal is to develop a summer clinical immersion experience that will spark bi-directional integration of design thinking across a biomedical engineering curriculum.

PI_NAMEs: MURFEE, WALTER L (contact)

PROGRAM_OFFICER_NAME: GUTEKUNST, DAVID JOSEPH

PROJECT_TERMS: Adoption;Area;Biomedical Engineering;Case Study;Case/Control Studies;Clinical;clinical translation;cohort;college;Communication;course sequence;design;Discipline;Ecosystem;Education;Educational Curriculum;Educational workshop;empowerment;Engineering;engineering design;Ensure;experience;Exposure to;Faculty;Family;flipped classroom;Florida;Goals;Healthcare;ideation;Immersion;Industry;industry partner;Infusion procedures;innovation;Interdisciplinary Communication;Lead;Leadership;Learning;learning materials;Link;Medical Device;medical specialties;Medicine;meetings;Modeling;multidisciplinary;open-ended problem;peer;peer coaching;Persons;Process;programs;prototype;Rotation;skill acquisition;skills;student mentoring;Students;Technology;Technology Transfer;Thinking;Time;translational potential;undergraduate student;Universities;Veterinary Medicine;virtual

PROJECT_TITLE: Team-Based Design for Clinical Translation


ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative The immune cells are diverse and have different functions despite they all share the same genome. Deciphering the regulatory program defining the cell types and cell state is thus important for developing new therapeutics.

PI_NAMEs: WANG, WEI  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Area;ATAC-seq;Autoimmunity;Biological;Biological Response Modifiers;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;Chromatin;clinical application;Code;comparative;Computer Analysis;computerized tools;Data;deep learning model;design;Development;differential expression;Enzymes;Foundations;Genes;Genetic;Genome;Genomics;Human;Human body;Immune;Immune system;immune system function;immunoengineering;immunoregulation;Immunotherapy;improved;Individual;Infection;insight;Malignant Neoplasms;Measurement;Metabolic;Metabolic Pathway;Methods;MicroRNAs;Modeling;Multiomic Data;multiple omics;Mus;Noise;novel;novel therapeutics;pathogen;patient response;Performance;Population;programs;protein protein interaction;Publishing;Regulation;Research;Resistance;Role;Signal Transduction;Signaling Protein;Specific qualifier value;Specificity;success;Surveys;System;Systems Biology;Tai Ji;Techniques;Technology;Testing;Therapeutic;therapeutically effective;tool;transcription factor;transcriptome;transcriptome sequencing;tumor;Vaccines;Virus;Work

PROJECT_TITLE: Systems-level identification of key regulators deciding immune cell state

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: GRAND FORKS

ORG_NAME: UNIVERSITY OF NORTH DAKOTA

ORG_STATE: ND

PHR: A U-RISE program at the University of North Dakota will provide safe, supportive and inclusive research training for high achieving underrepresented undergraduate students who may otherwise not have such an opportunity, therefore bringing more diversity into biomedical and bio-behavioral research careers.

PI_NAMEs: DARLAND, DIANE CATHERINE;DENNY, DAWN LUJEAN (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TERMS: Advisory Committees;biobehavior;career;cohort;Computing Methodologies;Doctor of Philosophy;Eligibility Determination;Enrollment;Ethnic Origin;experience;Funding;Future;Goals;Grooming;High School Student;improved;junior high school;Laboratory Research;Libraries;matriculation;member;Mentors;North Dakota;Northern Plains;programs;Publications;recruit;Reporting;Reproducibility;Research;Research Personnel;Research Training;Resources;responsible research conduct;Science;service learning;statistics;Structure;Students;summer research;Techniques;Training;Training Programs;undergraduate research;undergraduate student;Underrepresented Students;Universities;Writing

PROJECT_TITLE: U-RISE at the University of North Dakota

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Prevention;Substance Misuse

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE Alcohol consumption is an important modifiable lifestyle risk factor for cardiovascular disease (CVD). Advances in high-throughput technologies have made it possible to measure and analyze a variety of ‘omics’ (DNA methylation, gene expression, protein and metabolite) in relation to alcohol consumption and CVD in a cost- efficient manner with existing resources. With completion of this project, we will have better understanding of the alcohol-associated molecular mechanisms between alcohol consumption and CVD, and highlight novel targets for the prevention and treatment of alcohol-associated CVD.

PI_NAMEs: LIU, CHUNYU  (contact);MA, JIANTAO

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Address;adjudication;alcohol abuse therapy;Alcohol consumption;alcohol effect;Alcohols;American;Applications Grants;bioinformatics tool;Biological Markers;Calories;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular risk factor;causal variant;cohort;Complex;Computer software;Coronary heart disease;cost efficient;Databases;dietary guidelines;Dimensions;Disease;Disease Outcome;DNA Methylation;Framingham Heart Study;Future;Gene Expression;Genes;Genotype-Tissue Expression Project;Goals;Healthy Eating;high throughput technology;Human;Interdisciplinary Study;Investigation;Ischemic Stroke;Knowledge;Life Style;Measures;Mediating;Mediation;Medical;Mendelian randomization;metabolome;metabolomics;Methods;methylation biomarker;methylome;modifiable lifestyle factors;Molecular;Molecular Profiling;Molecular Target;multidisciplinary;Multiomic Data;multiple omics;Myocardial Ischemia;Neurodegenerative Disorders;novel;Participant;Pathway Analysis;Pathway interactions;Pattern;Phenotype;Plasma;Plasma Proteins;polygenic risk score;Prevention;Process;Proteins;Proteome;Proteomics;public health priorities;random forest;Recommendation;Resources;Risk Factors;Sampling;Testing;transcriptome;transcriptomics;Treatment Cost

PROJECT_TITLE: Trans-omic Analysis of Alcohol Consumption and its Relation to Cardiovascular Disease

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ORG_CITY: PULLMAN

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The proposed program represents a multi-faceted approach to multi-disciplinary undergraduate education, involvement of individuals from diverse groups in gerontechnology research, and preparation of individuals at many levels to meet the nation's need for gerontechnology research. The result of this project will be to educate groups of undergraduates in a multidisciplinary manner to prepare them for graduate school and research careers in the field. Additionally, the remote speakers, online materials, and symposia will bring in other researchers, teachers, and industry members to help spread knowledge about this field and its long-term impacts on our society. This program is relevant because it will expand and more greatly diversify the ranks of eldercare researchers in the fields of engineering, computer science, sociology, nursing, psychology, and others relevant to healthcare and MSTEM disciplines.

PI_NAMEs: COOK, DIANE JOYCE (contact);MINOR, BRYAN ;SCHMITTER-EDGECOMBE, MAUREEN

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Address;Aging;aging population;aging process;Alzheimer's disease related dementia;Area;care systems;career;career preparation;Caring;certificate program;Child;Chronic Disease;Clinical;clinical training;Collaborations;college;Communities;computer science;course sequence;demographics;design;Development;Disabled Persons;disadvantaged background;disadvantaged student;Discipline;Discipline of Nursing;Disparity population;Education;Educational Curriculum;Educational workshop;Engineering;Environment;Exhibits;experience;Faculty;Female;Fostering;Funding;Future;Generations;Gerontology;Goals;graduate school;graduate school preparation;graduate student;Health;Health care facility;Healthcare;healthy aging;High School Student;Human;improved;Independent Living;Individual;Industry;innovation;Institution;interest;Internships;Knowledge;Lead;Learning;lectures;Long-Term Care for Elderly;Medical;Medicine;meetings;member;Mentors;Methods;Minority;multidisciplinary;Museums;Neurosciences;novel strategies;older adult;Older Population;Participant;Persons;podcast;Population;Preparation;Prevalence;primary outcome;programs;Psychology;Publications;Qualifying;Quality of Care;Recording of previous events;recruit;Research;Research Methodology;Research Personnel;Research Project Grants;Research Training;responsible research conduct;Science;secondary outcome;Self-Help Devices;Series;service learning;smart environment;Societies;Sociology;Students;summer program;summer research;summer student;symposium;System;teacher;Technology;Time;Training;Training Programs;training project;undergraduate education;undergraduate research experience;undergraduate student;Underrepresented Populations;Universities;Vision;Woman;Work;Writing

PROJECT_TITLE: Multidisciplinary undergraduate training program in Health-assistive Smart Environments


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Telehealth

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: Project narrative Through a randomized control trial and subsequent stepped-wedge designed study in high- volume facilities providing male circumcision (MC) in South Africa, we will demonstrate that two- way texting (2wT) between providers and patients increases adverse event (AE) ascertainment while reducing provider workload as compared to routine, in-person follow-up. Implementation science methods and costing analysis will rigorously evaluate 2wT, determining how to optimize 2wT-2-SCALE within routine MC program settings. It is expected that 2wT-2-SCALE will be a cost-effective method to improve MC efficiency and AE ascertainment at scale, enabling rapid, sustainable improvement in the quality of MC services at the population level.

PI_NAMEs: FELDACKER, CARYL  (contact);SETSWE, GEOFFREY KEITSHEPILE

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Absenteeism at work;Adherence;Adoption;Adverse event;Africa South of the Sahara;AIDS prevention;Budgets;Caring;Cells;Client;Clinic;Complication;Consolidated Framework for Implementation Research;cost;Cost Analysis;cost effective;cost estimate;Data;design;Detection;Diffusion of Innovation;Disincentive;Dissemination and Implementation;economic cost;Economics;Effectiveness;Eligibility Determination;Ensure;evidence base;follow-up;Goals;Guidelines;healing;health care quality;Health system;Healthcare Systems;high standard;Hour;implementation barriers;implementation context;implementation research;implementation science;implementation strategy;improved;Individual;innovation;insight;Intervention;Maintenance;Male Circumcision;Measures;Medical;men;Methods;mhealth interventions;microcosting;Modeling;Outcome;outreach;patient safety;Patients;peri-urban;Persons;Phase;Population;Postoperative Period;pressure;preventive intervention;Process Measure;Productivity;programs;prospective;Protocols documentation;Provider;provider adoption;Province;Public Health;Quality of Care;Quasi-experiment;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Reporting;Research;Research Design;Research Priority;Resources;response;routine care;Rural;rural area;rural health clinic;Safety;scale up;Serious Adverse Event;service delivery;Services;Severities;Site;social;South Africa;standard care;Stretching;System;Testing;treatment arm;two way texting;Uncertainty;uptake;Visit;wasting;Workload;Zimbabwe

PROJECT_TITLE: Expanding and Scaling Two-way Texting to Reduce Unnecessary Follow-Up and Improve Adverse Event Identification Among Voluntary Medical Male Circumcision Clients in the Republic of South Africa

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Microbiome;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Social Determinants of Health;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE There is an urgent need to identify the psychosocial impacts of the COVID-19 pandemic on pregnant women and their infants. The goal of this project is to examine consequences and mechanisms of COVID-related maternal stress, and to isolate protective postnatal factors that can inform future interventions relevant to children born around the world at this utterly challenging time.

PI_NAMEs: BRITO, NATALIE HIROMI (contact);THOMASON, MORIAH E

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: Animals;anxious behavior;Behavior;Behavioral;biobehavior;Biological;Brain;brain behavior;Buffers;caregiving;Caring;Child;Child Development;Chronic stress;cognitive function;cohort;Collection;Communities;Contracts;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 stress;Data;Data Set;Development;Disparity;early life stress;economic impact;Economics;Electroencephalography;Emotional;emotional distress;Enrollment;Environment;Environmental Risk Factor;Equilibrium;Event;experience;Exposure to;Family;Financial Support;Foundations;Future;Goals;gut microbiome;gut microbiota;Hair;Health;Heart Rate;Height;Human;Human Milk;Hydrocortisone;improved;Individual;infancy;Infant;Infant Development;Inflammation;inflammatory marker;interest;Intervention;Life;Link;Long-Term Effects;Longitudinal Studies;maternal stress;Measures;Medical;Mental Health;Mother-Child Relations;Mothers;neurobehavioral;Neurobiology;Neurocognition;Neurocognitive;neurodevelopment;neuropsychiatry;New York City;Outcome;pandemic disease;Parent-Child Relations;Pathway interactions;Pattern;Perinatal;perinatal period;Personal Satisfaction;Physiological;Population;postnatal;Postpartum Women;Pregnancy;pregnant;Pregnant Women;prenatal;promote resilience;prospective;protective factors;Protocols documentation;Psychopathology;psychosocial;public health emergency;Recording of previous events;recruit;Research;Resources;response;Rest;Risk;Severities;social;social norm;Social support;sociodemographic factors;sociodemographics;Stress;stressor;Surveys;System;Testing;Time;Toddler;transmission process;United States;Virus;Woman;Work

PROJECT_TITLE: Investigating neurobehavioral consequences of  COVID-19 related stressors on maternal mental health and infant development

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Synaptic loss and mitochondrial dysfunction are both associated with age and neurodegenerative disease. This proposal aims to determine what pathways can be leveraged to prevent or delay age- and disease-related synaptic loss using novel transcriptional and proteomic cell type-specific approaches. The training environment and plan catered to the applicant will promote success as an independent researcher in the field of aging research.

PI_NAMEs: FOX, STEPHANIE N (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Affect;Age;age related;age related changes;age related neurodegeneration;Aging;aging brain;alpha synuclein;Autopsy;Award;Bioinformatics;Biological Assay;Calcium;Cell Death;cell type;Cells;Cessation of life;Communities;Corpus striatum structure;Cre lox recombination system;Critical Pathways;cytochrome c;Data;Dependence;design;Development;Disease;Disease Progression;dopaminergic neuron;drug discovery;Electron Transport;Environment;estrogen-related receptor;Excision;experimental study;Exposure to;Family;Functional disorder;Future;Gene Expression;Gene Expression Profiling;Genes;genetic risk factor;Genetic Transcription;Goals;Hippocampus;Homeostasis;Impaired cognition;Impairment;improved;Injections;innovation;Knowledge;Knowledge acquisition;Lasers;Lewy Bodies;Lewy neurites;Light;Link;Maintenance;Manuscripts;Mediating;member;Membrane Potentials;Metabolic;Midbrain structure;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Motor;motor behavior;motor impairment;mouse model;Mus;Neurodegenerative Disorders;neuron loss;Neurons;neuroprotection;Neurosciences;neurotoxicity;novel;Nuclear;overexpression;Oxidative Stress;Parkinson Disease;Pathology;Pathway interactions;Patients;Peroxisome Proliferator-Activated Receptors;Phase;Population;Positioning Attribute;Postdoctoral Fellow;pre-clinical;pre-doctoral;pre-formed fibril;Preparation;prevent;Principal Investigator;Process;Production;Productivity;programs;protein expression;Proteomics;Publishing;Records;Regulation;Regulator Genes;Research;Research Personnel;Respiration;responsible research conduct;Role;Scientist;skills;Structure;Substantia nigra structure;success;Synapses;synaptic function;Techniques;Testing;Tissues;Toxic effect;Training;Transcription Coactivator;transcription factor;Up-Regulation;Work

PROJECT_TITLE: Omic profiling of vulnerable synapses in age-related neurodegeneration


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Epidermal growth factor receptor (EGFR) and its relatives are important drivers in several cancers, and are the targets of therapeutic inhibitors that block activation by attacking either the growth factor-binding or signaling kinase domains. The work proposed in this application will leverage our new mechanistic insights – alongside accumulating clinical mutation data – to explore whether agents that bias rather than block receptor signaling may reprogram cancer cells, and will also provide new insight to guide optimal inhibitor choice in different cancer settings where resistance occurs.

PI_NAMEs: FERGUSON, KATHRYN M;LEMMON, MARK A (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Affect;Affinity;Agonist;Antibodies;AREG gene;Behavior;Binding;Biochemical;Biophysics;cancer cell;Cancer Etiology;Cells;Clinic;Clinical;Coupled;Crystallography;Data;Databases;Deuterium;dimer;Dimerization;Disease;EGF gene;Enzymatic Biochemistry;Epidermal Growth Factor Receptor;Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor;epigen;Epiregulin;ERBB3 gene;Exons;extracellular;Extracellular Domain;Family member;Fc Receptor;Funding;G-Protein-Coupled Receptors;Gene Amplification;Gene Mutation;Generations;Glioblastoma;Goals;Grant;Growth Factor;Hydrogen;inhibitor;inhibitor therapy;insight;kinase inhibitor;Kinetics;Ligands;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Microprocessor;Molecular Conformation;mutant;Mutate;Mutation;Nature;novel therapeutic intervention;Oncogenic;Outcome;Patients;Pharmaceutical Preparations;Phosphotransferases;programs;Property;prototype;Rationalization;receptor;Receptor Activation;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Reporting;Resistance;Resolution;response;Signal Transduction;Specificity;Structure;success;targeted treatment;Testing;Therapeutic Intervention;Transmembrane Domain;Tyrosine Kinase Domain;Tyrosine Kinase Inhibitor;Variant;Work

PROJECT_TITLE: Understanding EGF receptor activation by growth factors and oncogenic mutations

STUDY_SECTION: MIST

STUDY_SECTION_NAME: Molecular and Integrative Signal Transduction Study Section[MIST]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Kidney Disease;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative: Chronic kidney disease (CKD) leads to elevated blood pressure (BP) and elevated BP in turn accelerates CKD progression. Scientific knowledge gained from the study of CKD and elevated BP in sub- Saharan African can inform the development of health care policy to address the burden of these conditions in this region and generate valuable insights regarding disease pathogenesis in people with recent African ancestry who carry a disproportionate burden disease around the world, including in the US.

PI_NAMEs: MUIRU, ANTHONY N (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acceleration;Address;Africa;Africa South of the Sahara;African;African ancestry;Biological Markers;biomass fuel;Biostatistical Methods;Blood Pressure;blood pressure elevation;burden of illness;career;Certification;Chronic;Chronic Kidney Failure;clinical investigation;Clinical Research;clinically significant;Collection;Community Health;community health study;cooking;Cross-Sectional Studies;Development;Diabetes Mellitus;Disease;Disease Progression;drinking water;Enrollment;Environmental Epidemiology;Epidemiologic Methods;Epidemiology;Etiology;experience;Fellowship;follow-up;Foundations;Functional disorder;geographic difference;Geographic Distribution;Glomerular Filtration Rate;Goals;Health Policy;Hematuria;High Prevalence;HIV Infections;HIV Seropositivity;Hour;Household;Human immunodeficiency virus test;Hypertension;Individual;Inflammation;Infrastructure;Injury;insight;Kenya;Kidney;Kidney Diseases;Knowledge;Longitudinal cohort;Longitudinal cohort study;masked hypertension;Measurement;Measures;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;multidisciplinary;Nature;nephrotoxicity;Nitrites;Nocturnal Hypertension;Participant;Pathogenesis;patient oriented;Patients;Persons;pesticide exposure;Pesticides;Phenotype;Pollution;Population;Prevalence;Proteinuria;Public Health;regional difference;Renal function;Research;Research Infrastructure;Research Personnel;Resource-limited setting;Risk Factors;Rural;Rural Community;Sampling;skills;Source;Specialist;Standardization;Time;Traditional Medicine;Training;Tubular formation;Uganda;urinary;Urine;Visit;white coat hypertension;Work

PROJECT_TITLE: SEARCH-CKD: The nature of chronic kidney disease and elevated blood pressure in sub-Saharan Africa.

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE BARD1 (BRCA1-Associated RING Domain protein-1) is an essential partner of the breast cancer susceptibility protein BRCA1 and is included in clinical panels of genes used to evaluate patients with suspected hereditary cancer predisposition, especially breast and ovarian cancers. Despite this, almost nothing is known about the cellular role of BARD1. This project aims to address this serious gap in knowledge by defining at a molecular level how BARD1 contributes to DNA damage repair and transcriptional repression.

PI_NAMEs: BRZOVIC, PETER S;KLEVIT, RACHEL E (contact)

PROJECT_TERMS: Ablation;Address;Ankyrin Repeat;Architecture;BARD1 gene;Behavior;Binding;Biochemical;Biological;biophysical techniques;Biophysics;BRCA1 gene;BRCT Domain;Breast Cancer Patient;cancer predisposition;Cell Physiology;Cells;Chemicals;Clinical;Complex;crosslink;Cryoelectron Microscopy;design;Detection;Deuterium;Disease;DNA;DNA Repair;EMSA;gene repression;Genes;Goals;Hereditary Malignant Neoplasm;Histone H2A;Histones;homologous recombination;Hydrogen;insight;Knowledge;Learning;Length;Ligase;loss of function;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Modification;Molecular;Molecular Conformation;mutant;Mutation;Nucleosomes;Patients;Phenotype;Poly Adenosine Diphosphate Ribose;Positioning Attribute;Predisposition;Proteins;recruit;Reporting;Resected;Resolution;Role;shared attention;Site;Structure;Tail;Testing;Transcriptional Regulation;Tumor Suppressor Proteins;Ubiquitin;ubiquitin-protein ligase;Work

PROJECT_TITLE: Defining the role of BARD1 in nucleosomal ubiquitylation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Cellular volume control and protein phosphoregulation are fundamental processes in biology, and their misregulation have been linked to several diseases and developmental defects. Using novel genetic tools in the model plant Arabidopsis, we will elucidate PP2C phosphatase function and regulatory mechanisms in the control of cell expansion mediated by the hormone auxin. These studies will identify components and phosphoregulatory mechanisms employed by eukaryotes to modulate cell size during growth and development.

PI_NAMEs: GRAY, WILLIAM M (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: Affect;Arabidopsis;ATP phosphohydrolase;Auxins;Binding Proteins;Biological Models;Biology;Cardiovascular Diseases;Cell membrane;Cell Physiology;Cell Size;Cells;Data Set;Defect;Development;Diabetes Mellitus;Disease;enzyme activity;Eukaryota;Exhibits;Fiber;Food;Genes;Genetic;Goals;Growth;Growth and Development function;Health;Hormones;Human;Human Development;human disease;Link;Malignant Neoplasms;Mammalian Cell;Mediating;Molecular;neural;novel;novel strategies;organ growth;Orthologous Gene;overexpression;Pharmacologic Substance;Phosphoproteins;phosphoproteomics;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;plant growth/development;Plant Model;Plant Sources;Plants;Play;Process;Protein Dephosphorylation;protein phosphatase 2C;Proteins;Proton-Translocating ATPases;Regulation;Repression;Research;response;RNA;Role;Serine/Threonine Phosphorylation;Signal Transduction;Somatotropin;Stress;tool;Work

PROJECT_TITLE: Molecular mechanisms of auxin response

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Pediatric

ORG_CITY: SAN ANTONIO

ORG_DEPT: BIOLOGY

ORG_NAME: ST. MARY'S UNIVERSITY

PHR: Project Narrative St. Mary’s University is a Hispanic-serving institution in San Antonio, TX, with a long history of successfully preparing underrepresented minority students to enter professional schools. The URISE program will advance the research culture at St. Mary’s, increase the number of students interested in pursuing research careers and Ph.D.s in the biomedical sciences, and produce responsible biomedical scientists. Equally important, is that the broad exposure to biomedical science research will be beneficial to students who are not seeking higher degrees in STEM but, as a result, stay in STEM and join the biomedical workforce.

PI_NAMEs: CONTRERAS-SHANNON, VERONICA E (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Bachelor's Degree;Biomedical Research;biomedical scientist;career;CCL7 gene;cohort;community college;Degree program;design;Development;Doctor of Medicine;Doctor of Philosophy;Educational Curriculum;Exposure to;Faculty;high school;High School Student;Hispanic-serving Institution;interest;Mentors;next generation;outreach;programs;Recording of previous events;recruit;Research;Schools;Science;skills;STEM research;Students;Training;Training Programs;transfer student;undergraduate student;underrepresented minority student;Underrepresented Students;Universities

PROJECT_TITLE: U-RISE at St. Mary's University


NIH_SPENDING_CATS: Bioengineering;Cardiovascular

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative. The process to develop new therapies involves multiple studies and clinical trials that can be time consuming, expensive, and potentially redundant depending on the available information. In this project we propose developing novel statistical methods that facilitate information sharing across data sources and are incorporated into adaptive trial designs that are more flexible than traditional designs. This work aims to improve the efficiency of clinical trials by incorporating supplemental sources of data to reduce the overall time needed, minimize the exposure of participants to less effective study arms, and conserve resources by taking advantage of previously collected sources of data.

PI_NAMEs: KAIZER, ALEXANDER MARK (contact)

PROGRAM_OFFICER_NAME: COADY, SEAN

PROJECT_TERMS: Address;Agreement;American;American Heart Association;arm;Award;Biology;Biometry;Cardiology;Cardiovascular Physiology;Cardiovascular system;Clinical;Clinical Trials;Clinical Trials Design;Colorado;Complex;Computer software;Consumption;Coupled;Data;Data Set;Data Sources;design;Development;Diabetes Mellitus;Economics;Ethics;Evaluation Studies;experience;flexibility;Future;Goals;improved;Informatics;Lipids;Lipoproteins;Medical;Medical center;Medicine;meetings;member;Mentored Research Scientist Development Award;Mentors;Mentorship;Metabolism;Methodology;Methods;Modeling;National Heart, Lung, and Blood Institute;novel;novel therapeutics;Outcome;Outcomes Research;Participant;Phase;precision medicine;premature;Probability;Process;professor;Property;prospective;Protocols documentation;Research;research clinical testing;Research Design;Research Personnel;Resource Allocation;Resources;Role;Sampling;Series;simulation;Software Tools;Source;standard of care;Statistical Methods;System;Testing;Time;Training;Translating;treatment arm;treatment strategy;trial design;Universities;user friendly software;Validation;wasting;Work

PROJECT_TITLE: Statistical Methods and Adaptive Trial Designs for Cardiovascular Outcomes with Information Sharing

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Brain Disorders;Data Science;Genetics;Human Genome;Mental Health;Substance Misuse

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Alcohol use disorder (AUD) affects millions of people in the US. Although genetic studies have identified loci associated with AUD, its genetic etiology has not been fully explained. This project aims to 1) develop integrative methods for analyzing large-scale genomic datasets of AUD to increase power for genetic discovery, and 2) elucidate the genomic architecture of AUD by using systems biology approaches.

PI_NAMEs: NGUYEN, TAN HOANG  (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Affect;Alcohol abuse;alcohol effect;alcohol misuse;alcohol use disorder;Alcohols;Architecture;Big Data;biobank;Biological;Brain;Caenorhabditis elegans;career;Code;cohort;comorbidity;cost;CRISPR/Cas technology;Data;data integration;Data Set;Disease;disease classification;disorder risk;drinking;Dryness;Etiology;exome sequencing;experience;experimental study;flexibility;functional genomics;Funding;Genes;Genetic;genetic architecture;Genetic Diseases;genetic information;Genetic Models;Genetic Predisposition to Disease;Genetic Risk;Genetic study;genome sequencing;genome-wide;genomic data;Genomics;Goals;heuristics;Hi-C;Investigation;Knowledge;large scale data;Mathematics;Mental Health;Mentors;Mentorship;Meta-Analysis;Methods;model organism;Multiomic Data;National Institute on Alcohol Abuse and Alcoholism;neuropsychiatric disorder;non-genomic;Nucleotides;Pathway interactions;Persons;Phenotype;phenotypic data;Proteome;Proxy;Psychopathology;Public Health;rare variant;Reporting;Research;resilience;Resources;Risk;risk variant;RNA Interference;Sequence Analysis;Signal Transduction;statistics;Systems Biology;Testing;Time;Training;trait;transcriptome;translational research program;United States;United States National Institutes of Health;Untranslated RNA;Validation;Variant;whole genome;Work

PROJECT_TITLE: Understanding the genomic basis of problematic alcohol use through integrative analysis of multi-omics data

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Given the obesity epidemic, it is critical that we understand how energy balance regulates hunger and satiety. While much has been learned, we still do not know how hypothalamic hunger / satiety neurons engage higher limbic/reward brain sites to control eating. This is because the “relay” between these hypothalamic neurons and the limbic/reward brain sites, the parabrachial nucleus (PBN), is a “black box”. This grant uses single neuron transcriptomics, mouse genetic engineering and neuron-specific neuroscience “tools” to: a) more clearly delineate the PVH satiety neurons that are upstream of the PBN, b) deconvolute the PBN interoceptive “black box” relay, and c) identify the PBN satiety neurons – ultimately leading to a mechanistic understanding of how alterations in energy balance compel or restrain eating.

PI_NAMEs: LOWELL, BRADFORD B (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Adaptive Behaviors;Address;Amygdaloid structure;Atlases;Behavioral Mechanisms;Black Box;blind;Brain;Cells;Complex;Confusion;Darkness;delta opioid receptor;Eating;Elephants;emotion regulation;Emotional;energy balance;Enkephalins;Equipment and supply inventories;FOXP2 gene;Genes;Genetic Engineering;Genetic Transcription;Goals;Grant;high reward;Hunger;Hypothalamic structure;Image;in situ sequencing;Investigation;Knowledge;Label;Learning;Leptin;Link;Maps;Mediating;men;Modality;Morbidity - disease rate;mortality;motivated behavior;mouse genetics;neuromechanism;Neurons;Neurosciences;Obesity;Obesity Epidemic;parabrachial nucleus;Penetration;Personal Satisfaction;Physiological;Play;positive emotional state;prevent;Process;Resources;response;restraint;Rewards;Role;Route;Satiation;Signal Transduction;Site;tool;transcriptomics

PROJECT_TITLE: The AgRP / POMC -> Paraventricular (PVH) -> Parabrachial (PBN) -> Limbic/Reward Satiety Circuit

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Spinal muscular atrophy (SMA) is an oft-fatal motor neuron disease caused by low SMN protein. SMN repletion appears to benefit some patients, but very little is known about how the protein protects the motor neurons and muscle, or if the currently available SMA treatments will be entirely curative. Here we wish to investigate these vitally important questions. Our research will result in a fuller understanding of the biology of SMA and is thus expected to inform improved treatments for this and similar neurodegenerative disorders.

PI_NAMEs: MONANI, UMRAO  (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: 2 year old;Address;adeno-associated viral vector;Adopted;Affect;Age;Alzheimer's Disease;Antisense Oligonucleotides;Area;autosome;Biology;Cell Physiology;Cells;Characteristics;Childhood;Chronic;Clinical;clinically relevant;Data;Defect;Development;Disease;disease phenotype;Early treatment;Encapsulated;Experimental Designs;Experimental Genetics;experimental study;FDA approved;gene replacement;Genes;Genetic;genetic linkage analysis;genetic strain;Genetic study;Genome;Goals;Growth;Housekeeping;Human;human disease;Impairment;improved;Individual;infancy;Intervention;Intuition;Left;Length;Light;Maintenance;model organism;Molecular Chaperones;Motor Neuron Disease;Motor Neurons;mouse model;Mouse Strains;Mus;Muscle;Muscle Cells;Muscle Development;muscle regeneration;muscle repair;Muscle satellite cell;Muscular Atrophy;Mutation;Neurodegenerative Disorders;neuromuscular;Neuromuscular Diseases;neuromuscular system;neuron loss;neurotransmission;new therapeutic target;notch protein;novel;Onset of illness;optimism;Outcome;Paralysed;Pathology;Pathway interactions;Patients;Phenotype;pre-clinical;prevent;progenitor;Proteins;proteostasis;Reporting;Research;Residual state;Respiratory distress;RNA Splicing;self-renewal;Severities;Signal Transduction;Skeletal Muscle;small molecule;SMN protein (spinal muscular atrophy);SMN1 gene;SMN2 gene;Sorting;Spinal;Spinal Muscular Atrophy;stem;stem cell division;stem cells;success;symptom treatment;Synapses;Testing;Therapeutic;Therapeutic Agents;therapeutic evaluation;Tissues;Transcript;Translating;Variant;Viral Vector;Work

PROJECT_TITLE: Mechanisms and SMN-Independent Therapies for Spinal Muscular Atrophy

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


ORG_CITY: ANN ARBOR

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative: Interruption of blood flow to the brain during ischemic stroke results in extensive brain damage. However, restoration of blood flow to oxygen-starved tissue by reperfusion produces free radicals that induce additional brain damage. We will investigate the ability of near infrared light, which non-invasively penetrates tissues, to prevent the formation of these free radicals through inhibition of a key metabolic enzyme in the process responsible for generating free radicals under conditions of stress.

PI_NAMEs: HUETTEMANN, MAIK ;SANDERSON, THOMAS HUDSON (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Algorithms;Animal Model;Attenuated;attenuation;Basic Science;Binding Sites;Blood flow;Brain;Brain Injuries;Brain Ischemia;Cause of Death;Cells;Cellular Stress;Cerebrum;Clinical;clinical implementation;cytochrome c oxidase;Data;Development;Electron Transport;Enzymes;Free Radical Formation;Free Radicals;Future;Generations;Goals;Histologic;Hour;Hyperactivity;in vivo;innovation;Interruption;Intervention;Ischemia;Ischemic Brain Injury;Ischemic Stroke;Knock-out;Laboratories;Light;Long term disability;Macrophage;Magnetic Resonance Imaging;Mediating;Membrane Potentials;Metabolic;Middle Cerebral Artery Occlusion;Mitochondria;mitochondrial membrane;Modeling;Modification;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Mus;Neuroglia;neuroinflammation;Neurologic;neuroprotection;neurovascular injury;neurovascular unit;novel;Obstruction;Oxidases;Oxygen;Parkin;Patients;Penetration;Peripheral;Pharmaceutical Preparations;pharmacologic;Phase;Phosphorylation;Phototherapy;prevent;Process;Production;programs;Property;Protocols documentation;Quality Control;rational design;Rattus;Reactive Oxygen Species;Reperfusion Injury;Reperfusion Therapy;Reporter;Research;restoration;standard care;standard of care;Starvation;Stress;Stroke;stroke model;stroke therapy;Technology;Testing;Therapeutic;Therapeutic Uses;therapy design;Time;Tissue Model;Tissues;Transgenic Mice;Translations

PROJECT_TITLE: Non-invasive mitochondrial modulation therapy for ischemic stroke

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Genetics

ORG_CITY: DALLAS

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE  The importance of circadian clocks in human physiology and mental health is evident from their ubiquitous influence on a wide range of cellular and organismal processes, and the malfunction of the clock is known to be associated with several forms of human psychiatric illness and with sleep disorders. On the other hand, codon usage biases are found in all organisms examined and play an important role in determining gene expression levels and protein structures. A better understanding of these two fundamental mechanisms will potentially lead to better understanding of diverse biological processes and potential therapeutic approaches for treating human diseases.

PI_NAMEs: LIU, YI  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Animals;Behavioral;Biochemical;Biological Phenomena;Biological Process;Cell Physiology;cell type;circadian;circadian pacemaker;Circadian Rhythms;Codon Nucleotides;CSNK1A1 gene;Disease;Drosophila genus;Eukaryota;Frequencies;fungus;Gene Expression;Gene Proteins;Genetic Code;Genetic Screening;Genetic Transcription;Genome;Goals;Human;human disease;in vivo;Mammals;Mental disorders;Mental Health;Methods;Molecular;Mus;Neurospora;novel;Organism;Output;Phosphorylation;Physiological;Physiological Processes;Physiology;Play;Process;protein folding;protein structure;Proteins;Reporter;Role;Sleep Disorders;Speed;System;temporal measurement;Therapeutic;Tissues;Translations;Work

PROJECT_TITLE: Mechanisms of circadian clock and codon usage biases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Nutrition;Prevention;Substance Misuse;Substance Misuse Prevention

ORG_CITY: OMAHA

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE  Liver damage caused by alcohol abuse or high fat is a growing health problem with no approved medication. We aim to develop innovative liver-targeted nanomedicines to treat liver diseases by using the Hh pathway inhibitor MDB5 and anti-miR-96, without eliciting adverse effects.

PI_NAMEs: MAHATO, RAM I. (contact);OSNA, NATALIA ALEKSANDR

PROGRAM_OFFICER_NAME: DOO, EDWARD

PROJECT_TERMS: Ablation;ADD-1 protein;Adrenal Cortex Hormones;Adverse effects;Affect;Alanine Transaminase;Alcohol abuse;alcohol prevention;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Animal Model;Anti-Inflammatory Agents;Antioxidants;Apoptosis;Aspartate Transaminase;B-Lymphocytes;Binding;Biodistribution;cell injury;Cells;Cessation of life;Chemicals;chronic liver disease;Cirrhosis;Collagen;Combined Modality Therapy;copolymer;cytokine;Deposition;Development;diacylglycerol O-acyltransferase;Diet;Disease;Disease Progression;Drug Kinetics;Economic Burden;effective therapy;epithelial to mesenchymal transition;Erinaceidae;Ethanol;Etiology;Evaluation;Extracellular Matrix;Fatty acid glycerol esters;fatty liver disease;Fibrosis;Formulation;FOXO1A gene;FOXO3A gene;Genes;GLI gene;GLI-1;GLI2 gene;global health;Glycogen;Glycyrrhetinic Acid;Goals;Health;Hepatic;Hepatic Stellate Cell;Hepatocyte;hepatoprotective;High Fat Diet;immunoreaction;Immunosuppressive Agents;Impairment;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;innovation;Insulin Receptor;insulin receptor substrate 1 protein;insulin signaling;knock-down;Kupffer Cells;Ligands;lipid biosynthesis;Liquid substance;Liver;Liver diseases;Liver Fibrosis;liver inflammation;liver injury;liver repair;Liver Stem Cell;Macrophage;MADH7 gene;Mediating;Metabolic Diseases;MicroRNAs;Minor;mortality;mouse model;mRNA Expression;mRNA sequencing;Mus;Myofibroblast;nanoformulation;nanomedicine;nanomolar;nanoparticle;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Obesity;Pathogenesis;Pathway interactions;Patients;Pharmaceutical Preparations;Play;preclinical evaluation;prevent;Production;Regulatory Pathway;repaired;restoration;Role;Sampling;Scanning;SHH gene;side effect;Signal Induction;Signal Pathway;Signal Transduction;TGFB1 gene;Therapeutic;Toxic effect;Transfection;Transforming Growth Factor beta;Transforming Growth Factors;Treatment Efficacy;Up-Regulation;Validation

PROJECT_TITLE: Development and Preclinical Evaluation of Nanoformulations in Liver Fibrotic Mice

STUDY_SECTION: NANO

STUDY_SECTION_NAME: Nanotechnology Study Section[NANO]