NIH_SPENDING_CATS: American Indian or Alaska Native;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

ORG_STATE: CA

PHR: PROJECT NARRATIVE  Despite mass incarceration in the US, we still do not fully understand all the consequences associated with exposure to the criminal justice system, especially for vulnerable populations such as Native Americans. This study's goal is to provide rigorous quasi- experimental evidence on how criminal justice exposure influences mortality and disparities in mortality among a statewide population of arrestees, who were assigned to prison, jail, community supervision, or released.

PI_NAMEs: NICOSIA, NANCY  (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: Address;Affect;African American population;Budgets;Cause of Death;Censuses;Cessation of life;Characteristics;Classification;Communities;contextual factors;Country;Criminal Justice;Data;design;Disparity;Disparity population;Economics;Equilibrium;ethnic disparity;Ethnic Origin;Evaluation;Excess Mortality;experience;experimental study;Exposure to;Family;General Population;Goals;Health;health disparity;Health system;Imprisonment;improved;Individual;Jail;Justice;Literature;Location;Methods;Minority Groups;mortality;mortality disparity;mortality risk;National Institute on Minority Health and Health Disparities;Native Americans;Outcome;parole;Policies;Policy Analysis;poor health outcome;Population;Prisoner;Prisons;probation;probationer;Public Health;Quasi-experiment;Race;racial disparity;Recording of previous events;Records;Risk;Risk Behaviors;Rural Population;Safety;Sampling;Selection Bias;Severities;sex;social implication;Societies;sociodemographic group;sociodemographics;South Dakota;Supervision;System;Time;Urbanicity;Variant;Vulnerable Populations

PROJECT_TITLE: Examining Racial/Ethnic Disparities in Mortality Associated with the Criminal Justice System

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Mental Health;Mental Illness;Neurosciences;Prevention;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: GAINESVILLE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Tobacco is highly addictive and even when using smoking cessation drugs the relapse rate is very high. The goal of our studies to provide new insight into the neurobiological mechanisms that lead to a high level of smoking and the depressive-like state associated with smoking cessation. If successful, these studies may lead to new smoking cessation aids that diminish withdrawal and decrease the risk for relapse.

PI_NAMEs: BRUIJNZEEL, ADRIAAN WILLEM (contact)

PROGRAM_OFFICER_NAME: MOORE, HOLLY MARIE

PROJECT_TERMS: Acute;Affect;Anhedonia;Animal Model;Animals;antagonist;Behavior;Brain;Catheters;Clinical Research;Corticosterone;Dependence;depressive symptoms;designer receptors exclusively activated by designer drugs;Development;Dialysis procedure;Dopamine;Dopamine Antagonists;Dopamine D1 Receptor;Dopamine D2 Receptor;drug relapse;Electrodes;Enterobacteria phage P1 Cre recombinase;Evaluation;experimental study;Female;Glucocorticoid Receptor;Glucocorticoids;Goals;Homeostasis;Hormones;Injections;insight;Intake;Intravenous;Knowledge;male;Measures;median forebrain bundle;Mediating;Methods;Microdialysis;Modeling;neurobiological mechanism;Neurons;Neuropeptides;Nicotine;nicotine cessation;Nicotine Dependence;nicotine self-administration;Nicotine Withdrawal;Nicotinic Receptors;Nucleus Accumbens;Persons;Play;prevent;programs;Property;Pump;Rat Transgene;Rattus;Receptor Activation;Receptor Signaling;Relapse;relapse risk;Research;Rewards;Rodent;Role;Self Administration;Self Stimulation;Signal Transduction;Smoke;Smoker;Smoking;smoking addiction;smoking cessation;Smoking Cessation Intervention;Stress;System;Testing;Time;Tobacco;Transgenic Organisms;transmission process;virtual;Withdrawal;Work

PROJECT_TITLE: Crosstalk between dopamine and glucocorticoids in high levels of nicotine intake and anhedonia in rats

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Prevention;Rare Diseases;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative: Mutations in the RAD51 paralogs are associated with cancer predisposition, particularly breast and ovarian cancers. Although the RAD51 paralogs were discovered in the 1990s, it remains unknown which RAD51 paralog mutations are pathogenic and how these mutations sensitize individuals to environmentally induced DNA damage and cancer. We are using a high throughput screening approach to determine which mutations are functionally important thus identifying individuals who may be at increased risk for cancer development.

PI_NAMEs: BERNSTEIN, KARA A (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Address;aging related;ATP phosphohydrolase;Biochemical;Biological;Biological Assay;Biological Markers;Bleomycin;brca gene;BRCA2 gene;cancer genome;cancer predisposition;cancer risk;Cells;Chromosome abnormality;Classification;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;Complex;cost effective;Development;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;DNA replication fork;DNA-Protein Interaction;Double Strand Break Repair;Embryo;Environment;Environmental Carcinogens;Environmental Exposure;environmental mutagens;epidemiology study;experimental study;Exposure to;Filament;Functional disorder;gene repair;Genetic;Genetic Polymorphism;Genetic Screening;genome integrity;Genomic Instability;Germ-Line Mutation;Goals;Hereditary Breast and Ovarian Cancer Syndrome;high throughput screening;homologous recombination;homologous recombination deficiency;Human;Human Cell Line;Hybrids;in vivo;Individual;individual patient;Inflammatory Response;Inherited;Injury;Invaded;Ionizing radiation;Knock-in;Knock-out;Knockout Mice;Knowledge;Link;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mammary Neoplasms;Measures;Mediating;member;Metaphase;Methods;Microscopy;Modeling;Molecular;Mus;mutant;Mutate;Mutation;next generation sequencing;novel;ovarian neoplasm;oxidative damage;Oxidative Stress Induction;PALB2 gene;paralogous gene;Pathogenicity;Pathway interactions;precision medicine;prevent;protein protein interaction;Proteins;RAD51C gene;Recombinant Proteins;recruit;repaired;Reporter;Role;Screening for Ovarian Cancer;screening panel;Source;System;Technology;Testing;Therapeutic;Time;Toxic Environmental Substances;toxicant;Tracer;tumor;Variant;variant of unknown significance;Visualization;Walker-A Motif;Woman;Work;XRCC2 gene;XRCC3 gene;Yeasts

PROJECT_TITLE: RAD51 paralog function in cancer predisposition and genome integrity

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: BOSTON

ORG_DEPT: SURGERY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

ORG_STATE: MA

PHR: Relevance narrative Approximately 19% of the US population resides in rural areas; for over three decades, this population has experienced increasingly inferior health outcomes when compared with their urban counterparts. The underlying cause(s) of the widening rural/urban gap in cancer outcomes is hypothesized to be multifactorial, and this study will provide a comprehensive multi-level evaluation of rural/urban mortality disparities. Findings will provide the critical evidence needed to inform policy, as well as to inform intervention development to address the systemic disparities in mortality experienced by rural patients with cancer.

PI_NAMEs: KENZIK, KELLY  (contact)

PROGRAM_OFFICER_NAME: DELLAVALLE, CURT TAVIS

PROJECT_TERMS: Address;Area;Behavioral Risk Factor Surveillance System;Black Populations;Black race;Budgets;cancer health disparity;Cancer Patient;Caring;Censuses;Characteristics;Clinical Trials;Code;cohort;Commuting;comorbidity;Complex;contextual factors;County;Data;data registry;Data Set;Databases;Death Rate;deprivation;Diagnosis;Disparity;Emergency department visit;Evaluation;evidence base;Excess Mortality;experience;Future;Geographic Factor;Geographic Locations;Geography;Health;Health behavior;Health Information National Trends Survey;Health Insurance;health literacy;Health Services Accessibility;Healthcare;Hospitalization;indexing;Individual;Inferior;Insurance;Intervention;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Mediation;Methodology;Modeling;mortality;mortality disparity;multilevel analysis;Nature;neoplasm registry;Office Management;Outcome;Participant;Play;Policies;Policy Developments;Policy Maker;Population;Poverty;Poverty Areas;primary outcome;Quality of Care;Race;Reasons for Geographic And Racial Differences in Stroke;Reporting;Research Personnel;Role;Rural;rural area;rural disparities;rural patients;Rural Population;rural poverty;rural residence;rurality;Sampling;screening;SEER Program;Social support;social vulnerability;sociodemographics;Socioeconomic Status;Specialist;statistics;Stroke Belt;System;therapy development;Transportation;urban area;urban disparity;urban residence;virtual;Work

PROJECT_TITLE: Understanding rural mortality disparities in cancer: a multi-level approach

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Lung;Lung Cancer;Prevention

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative Public Health Relevance Statement The early diagnosis of lung cancer is critical to patient survival. Unfortunately biopsy procedures that offer higher diagnostic yields are associated with significantly higher risks to the patient, and lower-risk bronchoscopic approaches are hampered by low diagnostic yields. The goal of this application is to develop a powerful optical bronchoscopy tool to increase the diagnostic yield of low risk approaches by 1) guiding biopsy site selection, and 2) by providing in vivo optical diagnoses that will allow for immediate treatment of the target tissue within the single clinical procedure.

PI_NAMEs: BOUMA, BRETT E;SUTER, MELISSA J (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;arm;Benign;Biopsy;Biopsy Specimen;Blinded;Breast;Bronchoscopy;cancer diagnosis;Cancer Etiology;Categories;Catheters;Cessation of life;Chest;Clinical;Clinical Research;Colon;computed tomography screening;Custom;Development;Diagnosis;Diagnostic;diagnostic accuracy;Diagnostic Procedure;Early Diagnosis;Early Intervention;Enrollment;Evaluation;Feasibility Studies;Goals;high resolution imaging;high risk;Histopathology;human subject;Image;Image Analysis;imaging approach;imaging platform;improved;in vivo;Individual;Laboratories;Lesion;low dose computed tomography;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Methods;microendoscopy;Microscopic;Microscopy;minimally invasive;Morbidity - disease rate;mortality;Nodule;novel;Operative Surgical Procedures;Optical Coherence Tomography;optical imaging;Optics;participant enrollment;Pathologist;Pathology;Patients;Physicians;Procedures;Prostate;public health relevance;Randomized;Reader;Recommendation;Research Design;Resolution;Risk;safety and feasibility;screening;Sheep;Site;Specimen;Structure;surgical risk;Survival Rate;Symptoms;Techniques;Technology;technology development;Therapeutic Intervention;Time;Tissue imaging;Tissue Sample;Tissues;tool;tumor;tumor microenvironment;United States Preventative Services Task Force;Unnecessary Surgery;Visualization;Work

PROJECT_TITLE: Early Detection and Diagnosis of Lung Cancer with Endomicroscopy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: OD

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Digestive Diseases;Genetics;Human Genome;Inflammatory Bowel Disease;Microbiome

ORG_CITY: PULLMAN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: PROJECT NARRATIVE The role of the gut microbiome in both canine and human inflammatory bowel disease (IBD) has been poorly understood because a patient specific experimental model that can reflect genetic heterogeneity and host- microbiome dynamics do not exist. My research proposes to develop a translational, patient-specific IBD Chip by integrating a microfluidic gut-on-a-chip and canine patient-derived intestinal organoids to recapitulate epithelium-microbiome-immune axis. The ultimate goal is to map the intestinal epithelium-microbiome crosstalk relevant to IBD by leveraging the single-cell multi-omics analysis while validating the findings with RNA in situ hybridization, which may lead to a broader impact on uncovering the underlying disease mechanism and developing new targeted anti-inflammatory drugs.

PI_NAMEs: AMBROSINI, YOKO MIYAMOTO (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: 16S ribosomal RNA sequencing;Advanced Development;Affect;Alzheimer's Disease;Animal Model;Anti-Inflammatory Agents;Attention;Bioinformatics;canine model;Canis familiaris;career development;Cell Culture Techniques;cell type;Cells;Chronic;Coculture Techniques;cohort;Colorectal Cancer;combinatorial;comparative;Complex;Coupling;design;Development;Development Plans;Diabetes Mellitus;Disease;disease model;dysbiosis;Electron Microscopy;Epidemiology;Epithelium;Experimental Models;Extramural Activities;fabrication;Functional disorder;Funding;Gastroenterology;Genetic;Genetic Heterogeneity;Genetic Variation;Genome;Genomics;Germ-Free;Goals;gut microbiome;gut microbiota;Health;Heterogeneity;Homeostasis;host microbiome;Human;human disease;human model;Image;Immune;Impairment;improved;In Situ;In Situ Hybridization;In Vitro;in vitro Model;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Inflammatory Response;insight;intestinal epithelium;intestinal homeostasis;Intestines;Knowledge;Lead;Learning;Libraries;Maps;Medicine;Mentored Research Scientist Development Award;Mentors;microbial;microbial signature;microbiome;microbiome research;Microfabrication;Microfluidic Microchips;Microfluidics;Mission;Modeling;Molecular;Molecular Biology;Molecular Profiling;multiple omics;Mutation;Names;new therapeutic target;novel;novel therapeutics;organ on a chip;Organoids;Outcome;participant enrollment;Pathogenesis;Pathologic;patient oriented;Patients;Persons;Pharmaceutical Preparations;Physiological;Physiology;pre-clinical;programs;Protocols documentation;Research;research and development;Research Personnel;response;RNA;RNA Sequences;Role;Scanning Electron Microscopy;Scientist;single-cell RNA sequencing;skills;spatiotemporal;stem cell biology;stem cells;Techniques;Technology;tenure track;Therapeutic;Therapeutic Intervention;Training;transcriptome;transcriptomics;translational medicine;Transmission Electron Microscopy;United States National Institutes of Health;Validation;Visualization;Work

PROJECT_TITLE: Deciphering the Role of Gut Microbiome in Inflammatory Bowel Disease Using a Canine Patient-Specific Gut-on-a-Chip


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Assistive Technology;Autoimmune Disease;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Diabetes;Lung;Nutrition;Pediatric;Prevention;Rare Diseases

PHR: Project Narrative Cystic fibrosis-related diabetes affects up to half of patients with cystic fibrosis, and is associated with undesired weight loss, worsening lung function, and earlier death. Treatment with insulin can reduce the risk of these bad outcomes, but achieving good blood sugar control with insulin requires lots of work on the part of patients and greatly increases the risk of dangerous low blood sugars. We plan to test the idea that the bionic pancreas, a device already shown to automatically control blood sugar in type 1 diabetes, can be effective and safe in controlling blood sugar in patients with cystic fibrosis, and lead to weight gain, improved lung function, and improved quality of life.

PI_NAMEs: PUTMAN, MELISSA SUSAN (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Acute;Address;Adherence;Adolescent;Adult;Affect;Artificial Pancreas;Automation;autosome;Bionics;Blood Glucose;Body Composition;Body mass index;Body Weight decreased;Boston;Calories;Carbohydrates;care burden;Caring;Caucasians;Cessation of life;Clinical;Clinical Research;Collaborations;Complications of Diabetes Mellitus;Consumption;Continuous Glucose Monitor;Coupled;Cross-Over Trials;Crossover Design;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Dangerousness;design;Deterioration;Development;Devices;diabetes management;Diabetes Mellitus;Diet;Disease;Dose;Eating;European ancestry;Exocrine pancreatic insufficiency;experience;feasibility trial;Fibrosis;Fingers;Formulation;Glucagon;Glucocorticoids;Glucose;glucose monitor;glycemic control;Goals;high risk;Hormonal;Hospitalization;Hour;Hyperglycemia;Hypoglycemia;improved;Infection;Injections;inpatient service;Inpatients;Insulin;Insulin Infusion Systems;Insulin-Dependent Diabetes Mellitus;Intake;Life;Live Birth;Lung;Lung Diseases;mathematical algorithm;Medical;Monitor;Morbidity - disease rate;mortality;nutrition;Nutritional status;Organ;Outcome;Outpatients;Pancreas;patient population;Patients;Performance;Persons;Population;premature;prevent;Prevention;primary outcome;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary Inflammation;Pump;Quality of life;Questionnaires;Randomized;Recommendation;Regulation;Risk;Risk Reduction;Safety;satisfaction;sensor;Suspensions;System;Technology;Testing;Time;treatment as usual;trial comparing;trial design;United States;Universities;Weight;Weight Gain;Work

PROJECT_TITLE: Clinical studies of a bionic pancreas for automated glucose management in cystic fibrosis-related diabetes mellitus

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative. Despite decades of global efforts to tackle HIV-related stigma, our understanding of the effects of stigma and discrimination on HIV clinical outcomes remains inadequate. While resilience-based approaches hold great promise for mitigating the negative effects of HIV-related stigma (and other social stigma) on clinical outcomes of people living with HIV (PLWH), such promise has only been hypothesized but not empirically tested. The proposed study will be one of the first large scale efforts to examine whether resilience among PLWH can be fostered and sustained through a multilevel and multi-component behavioral intervention and whether such a resilience-based intervention can substantially improve the quality of treatment and care among PLWH in low- and middle-income countries as well as in other nations across the globe, including the United States.

PI_NAMEs: LI, XIAOMING  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Address;Adherence;Adopted;AIDS prevention;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;Attitude;Behavior Therapy;behavioral outcome;Biological;biological adaptation to stress;Biological Markers;Caring;CD4 Lymphocyte Count;China;Chronic stress;Clinic;Clinical;Cluster randomized trial;Communities;community collaboration;comparison control;Competence;contextual factors;Continuity of Patient Care;Couples;Data;Data Reporting;design;Development;Disclosure;Discrimination;Disease Progression;Epidemic;experience;Family;Family health status;Family member;family support;follow-up;Fostering;Funding;Hair;Health care facility;Health Personnel;Healthcare Systems;HIV;HIV Seropositivity;HIV/AIDS;Hydrocortisone;Immunologics;improved;Incidence;Individual;innovation;Institution;Intervention;intervention effect;Intervention Studies;Intervention Trial;Knowledge;Link;Longitudinal Studies;low and middle-income countries;Measures;Mediating;Medical;member;Mental Depression;Mental disorders;Methodology;Modality;multi-component intervention;multimodality;novel strategies;Outcome;Participant;Patient Self-Report;Persons;prevent;primary outcome;Protocols documentation;provider intervention;Psychological Factors;Psychological Stress;psychosocial outcome;Public Health;Quality of life;Randomized;randomized trial;Research;Research Infrastructure;Research Methodology;resilience;Resources;Self Efficacy;social stigma;Social support;Socioeconomic Status;Stigmatization;Stress;structural determinants;Testing;theories;therapy adherence;therapy design;treatment as prevention;Treatment Efficacy;United States;United States National Institutes of Health;Viral;Viral Load result;willingness

PROJECT_TITLE: Mitigate the effect of HIV-related stigma through a resilience approach

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Eating Disorders;Genetics;Mental Health;Mental Illness;Nutrition;Pediatric;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: PSYCHOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Binge eating is a significant mental health problem that affects a substantial proportion of males, and results in several negative psychiatric and medical consequences. Nonetheless, there is a paucity of research examining risk for binge eating in boys and men, and biological risk factors are extremely understudied. Identifying pubertal activation of phenotypic and genetic effects of androgens on binge eating could reveal a critical set of male-specific biological processes important for disease susceptiblity and novel targets for more personalized prevention and intervention efforts.

PI_NAMEs: CULBERT, KRISTEN ;KLUMP, KELLY L (contact)

PROGRAM_OFFICER_NAME: THOMAS, LAURA ANDERSON

PROJECT_TERMS: Address;Adolescent;Adrenal Glands;Affect;Age;Androgens;animal data;Animals;Anxiety;Behavioral Genetics;Behavioral Symptoms;Binge Eating;Biological;Biological Assay;Biological Factors;Biological Process;boys;Child;Chronic;Communities;Consumption;Data;design;Development;disability;Disease;Disparity;Eating;Eating Disorders;Equation;Etiology;Fatty acid glycerol esters;Female;Food;Funding;Genes;Genetic;Genetic Risk;Genetic Transcription;Hormonal;Hormones;Human;human data;improved;individualized prevention;innovation;insight;Intake;Interview;Knowledge;Libido;male;Male Adolescents;Medical;men;Mental Depression;Mental Health;Methods;Michigan;Modeling;Moods;Morbidity - disease rate;Neurobiology;novel;Obesity;Parents;Participant;personalized intervention;Phenotype;Predisposition;Prevention;Process;Production;psychiatric comorbidity;Psychopathology;Puberty;Public Health;Questionnaires;recruit;Registries;Regulator Genes;Reproducibility;Research;Risk;Risk Factors;Role;saliva sample;Same-sex;Sampling;secondary analysis;sex;Sex Differentiation;success;sugar;Syndrome;System;Testing;Testosterone;therapy development;Treatment Effectiveness;Twin Multiple Birth;Twin Studies;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: A Twin Study of Androgen Effects on Binge Eating Risk during Puberty in Males

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE / RELEVANCE TO PUBLIC HEALTH Staphylococcus epidermidis is a bacteria that broadly inhabits healthy human skin, yet it is also a common cause of skin infections and bloodstream infections associated with implanted medical devices. Because human skin has many different types of S. epidermidis, each containing different genes, our goal is to determine how these different genes allow S. epidermidis to switch from healthy growth in the skin to being an infectious pathogen. Understanding this switch is critical to developing new strategies to prevent and treat infections from S. epidermidis.

PI_NAMEs: OH, JULIA  (contact)

PROGRAM_OFFICER_NAME: UNDALE, ANITA H

PROJECT_TERMS: Address;Admixture;Affect;Bacteria;Behavior;Candidate Disease Gene;Characteristics;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;design;Disease;disorder risk;Ecosystem;Environment;experimental study;fitness;Gene Expression Profiling;gene function;gene network;Gene Targeting;Genes;Genetic;genetic architecture;Genetic Heterogeneity;genetic strain;Genetic study;Genetic Transcription;Genetic Variation;Genome;genome-wide;Genomic approach;Goals;Growth;Guide RNA;Health;Health Promotion;Homeostasis;Human;Immune system;immunoregulation;improved;In Vitro;in vivo;Individual;Infection;Infection prevention;Infectious Skin Diseases;Inflammation;insight;Investigation;knock-down;Knowledge;Life Style;Medical Device;medical implant;member;Metabolism;Methods;microbial;microbial community;Molecular;mucosal microbiota;Mucous Membrane;pan-genome;pathogen;Pathogenicity;Patients;Phenotype;Phylogenetic Analysis;Physiology;Population;Positioning Attribute;prevent;Process;Public Health;Regulation;Repression;RNA Sequences;Role;screening;Sepsis;Site;Skin;Skin colonization;skin disorder;skin microbiome;skin microbiota;Staphylococcus epidermidis;success;Testing;Therapeutic;tool;Virulence;virulence gene;whole genome

PROJECT_TITLE: Molecular Mechanisms of Staphylococcus Epidermidis Strain Diversity

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE This project aims at resolving long-standing problems in the encapsulation of insulin producing cells. As several groups are now on the verge of clinical translation of their production of insulin-producing cell aggregates, there is a clear need for the optimization of these delivery technologies. Through our proposed analysis of potential obstacles to engraftment of these tissues, it is our hope that we will co-develop, with our collaborators, a methodology for delivering these cellular products and optimizing their viability and function prior to clinical procedures. The public health impact of this research is a substantial reduction in the existing burden on the health care system that is imposed by treatment of Type 1 Diabetes Mellitus and the associated co-morbidities. If successful, the proposed work will lead to interventions that alleviate this burden and help the millions of patients worldwide afflicted with Type 1 Diabetes Mellitus. !

PI_NAMEs: FRAKER, CHRISTOPHER ALAN (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Alginates;Anoxia;Antigens;Apical;Apoptosis;Attention;Autoimmune;Biocompatible Materials;Blood Vessels;capsule;Cell Aggregation;Cell Death;Cell Physiology;Cell Survival;Cells;Chemicals;Clinical;clinical translation;clinically relevant;Coculture Techniques;comorbidity;Computer Models;cost;crosslink;Data;density;Devices;Diabetes Mellitus;Diffusion;Disease;Encapsulated;Engraftment;Environment;Epidemiology;Equilibrium;experience;Fluorocarbons;Functional impairment;Gases;Geometry;Glucose;Goals;Healthcare Systems;Hour;Hypoxia;Immunocompetent;immunodeficiency;Immunosuppression;Impairment;Implant;improved;In Vitro;in vivo;Inbred BALB C Mice;Incidence;Individual;Inflammatory;Inflammatory Response;Innate Immune Response;Insulin;Insulin-Dependent Diabetes Mellitus;Intervention;Investigation;islet;Islets of Langerhans Transplantation;Longevity;loss of function;Macrophage;Metabolic;Methodology;Methods;Microcapsules drug delivery system;monomer;mouse model;Mus;nanoemulsion;Nutrient;Oxygen;oxygen transport;Particle Size;Pathway interactions;Patients;Performance;Permeability;Polyethylene Glycols;prevent;Procedures;Production;Public Health;Research;Research Priority;response;restoration;Role;Streptozocin;Structure;Study models;success;Surface;System;Technology;Testing;Time;Tissue Transplantation;Tissues;Translations;Transplantation;Work

PROJECT_TITLE: Optimizing encapsulation to treat Type 1 diabetes mellitus: the role of oxygenation, antigen shedding and innate immune response in graft success


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Mental Health;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Preventing obesity among young children is a public health priority. This study will identify how mothers' self- regulation, or their capacity to control emotions, thoughts, and behaviors, may impact their parenting and, in turn, their young children's growth. Findings will inform the development of new approaches to prevent and treat childhood obesity.

PI_NAMEs: BAUER, KATHERINE W. (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Address;Adherence;Adult;Age;Behavior;behavior change;Body mass index;Cardiovascular Diseases;Child;Child Rearing;Child Support;Cognition;community partnership;critical period;Data;Data Collection;Development;diabetes management;dyadic interaction;early childhood;Eating Disorders;Effectiveness of Interventions;Elements;emotion regulation;Emotions;Enrollment;Environment;executive function;experience;Family;family support;Food;Future;Goals;Growth;Health Promotion;Healthy Eating;healthy weight;improved;Individual;Informal Social Control;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;Measures;Mediating;Methods;Mothers;novel;novel strategies;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;obesity treatment;Outcome;parental role;Parents;Patient Self-Report;Positioning Attribute;prevent;Prospective, cohort study;public health priorities;Research;Resources;Risk;Risk Factors;Role;Sampling;Skinfold Thickness;Sleep;sociodemographics;success;Testing;therapy design;Thinking;United States National Institutes of Health;Vulnerable Populations;Weight;Weight maintenance regimen;Work

PROJECT_TITLE: Maternal Self-Regulation and Early Childhood Obesity

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: HIV/AIDS

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Veterinarian scientists have unique expertise that enhances the rigor and reproducibility of research with animal models and improves animal welfare. To succeed in a research career, veterinarians must build on the foundation in comparative medicine gained through their veterinary education by engaging in PhD programs or postdoctoral fellowships that provide rigorous training in biomedical research, a path that ideally begins while still a veterinary student with the student participating in mentored research projects and networking with veterinarian-researcher role models. This proposal seeks to expand existing summer training program opportunities for veterinary students in biomedical research at the Johns Hopkins University (JHU) School of Medicine as a means to recruit more veterinarians to research careers with a T35-funded program that will complement and integrate into our existing summer programs that have >90% success in preparing veterinary students for research-intensive careers.

PI_NAMEs: MANKOWSKI, JOSEPH L (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Academic Medical Centers;Animal Model;Animal Welfare;base;Basic Science;Biomedical Research;career;career development;Clinical Medicine;comparative;Complement;Doctor of Philosophy;Endowment;Faculty;Fellowship;Foundations;Funding;Future;Home;Immersion;improved;Learning;medical schools;Medicine;Mentors;Molecular;Postdoctoral Fellow;professor;programs;recruit;Reproducibility;Research;Research Personnel;Research Project Grants;role model;Scholars Program;Scientist;student participation;Students;success;summer program;summer research;Training;Training Programs;Universities;Veterinarians;Veterinary Education

PROJECT_TITLE: Training Veterinary Students for Careers in Biomedical Research


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Microbiome;Nutrition;Post-Traumatic Stress Disorder (PTSD);Prevention

ORG_CITY: Aurora

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Exaggerated inflammation in the body and brain is thought to play a role in the vulnerability to and aggravation and perpetuation of adverse consequences among those with posttraumatic stress disorder (PTSD). The proposed study begins the process of investigating the use of a natural immunoregulatory/anti-inflammatory probiotic, Lactobacillus rhamnosus GG (LGG; ATCC53103), to treat chronic symptoms associated with PTSD among Veterans. By looking at the impact of probiotic supplementation on biological signatures of increased inflammation, as reflected by biomarkers of inflammation, gut microbiota composition, intestinal permeability, stress response, decision making, and PTSD symptoms, this study may identify a novel intervention for the treatment of symptoms associated with this frequently occurring condition.

PI_NAMEs: BRENNER, LISA A (contact);LOWRY, CHRISTOPHER A

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: 16S ribosomal RNA sequencing;Acceleration;active duty;Address;adverse outcome;alternative treatment;Anti-Inflammatory Agents;associated symptom;Biological;biological adaptation to stress;Biological Markers;Brain;C-reactive protein;Central Nervous System;chemokine;Chronic;Clinical;cognitive process;cohort;Communities;coping;cytokine;D-Amino Acid Dehydrogenase;Data;Decision Making;design;Diagnosis;Disease;DNA sequencing;Double-Blind Method;efficacy trial;emotion regulation;Evaluation;fatty acid-binding proteins;Freedom;Frustration;functional improvement;functional outcomes;Funding Opportunities;Future;Gambling;Goals;gut microbiota;Gut Mucosa;Health;Human;immunoregulation;Impairment;improved;Individual;Inflammation;Inflammatory;inflammatory marker;innovation;Interferon Type II;Interleukin-1 beta;Interleukin-10;Interleukin-2;Interleukin-4;Interleukin-6;Interleukin-8;Interleukins;Intervention;Intestinal permeability;Intestines;Iowa;Irritable Bowel Syndrome;Lactobacillus casei rhamnosus;Link;Measures;Mediating;Mental Health;Methods;microbiota composition;military service;military veteran;Mucositis;neuroprotection;novel;operation;Oral Administration;Organism;Outcome;Participant;Performance;Peripheral;persistent symptom;Pharmaceutical Preparations;Phase;Placebo Control;Placebos;Plasma;Play;Post-Traumatic Stress Disorders;post-traumatic symptoms;primary outcome;probiotic supplementation;Probiotics;Procedures;Process;Production;Property;psychologic;psychosocial;Psychotherapy;Quantitative Reverse Transcriptase PCR;Randomized;reduce symptoms;Research;Resistance;response;Risk;Risk Factors;Role;Safety;service member;Severities;Stress;stress reduction;Supplementation;symptom treatment;Symptoms;systemic inflammatory response;Testing;TNF gene;Trier Social Stress Test;United States;United States National Institutes of Health;Veterans

PROJECT_TITLE: Biological Signature and Safety of an Immunomodulatory Probiotic Intervention of Veterans with PTSD

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Mental Health;Pediatric;Social Determinants of Health

ORG_CITY: NOTRE DAME

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: The proposed research is relevant to public health because it provides a rigorous test of an in- novative, evidence-based and cost-effective intervention that is readily scalable to support bet- ter family functioning, tests mechanisms of effect for program impact, and evaluates organiza- tional factors contributing to program effects, all in the context of an RCT designed effective- ness trial. This is in response to RFA-MH-18-701, and is specifically relevant to NIMH’s mission because it contributes to the understanding of mental health problems in youth and contributes to prevention and intervention by utilizing a family-systems approach to improving the family en- vironment, which is a crucial developmental context with implications for mental health and ad- justment throughout the lifespan.

PI_NAMEs: BERGMAN, KATHLEEN NANETTE;BORKOWSKI, JOHN G;CUMMINGS, EDWARD MARK (contact)

PROGRAM_OFFICER_NAME: ROONEY, MARY

PROJECT_TERMS: Address;Adolescent;Age;Basic Science;brief intervention;Child;Church;Cities;Clinical Trials Design;Communication;Communities;community center;Community Participation;community setting;Conflict (Psychology);cost effective;cost effective intervention;design;Development;Educational Curriculum;Effectiveness;effectiveness evaluation;effectiveness testing;effectiveness trial;efficacy research;efficacy trial;Emotional;Environment;Ethnic Origin;evidence base;Evidence based program;experience;Family;family support;Feasibility Studies;Fostering;Gender;Goals;Happiness;improved;indexing;Indiana;innovation;Intervention;life span;Link;Literature;media use;Mediating;Mediator;member;Mental Health;Mission;Modeling;National Institute of Mental Health;organizational structure;Outcome;Parents;Participant;Pattern;Personal Satisfaction;Predisposition;Prevention;Process;Program Effectiveness;Program Evaluation;programs;psychoeducation;Public Health;Race;Randomized;recruit;Research;Research Assistant;Research Design;Resources;response;Risk;Sampling;satisfaction;Security;service providers;Site;social media;Social Work;socioeconomics;Source;Students;substance use;success;System;Testing;Theoretical model;theories;Time;Training;undergraduate student;Work;Youth

PROJECT_TITLE: Effectiveness of an Empirically Supported Family Intervention: Mental Health Outcomes, Mechanisms of Effect, and Organizational Factors


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Microbiome;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Sexually Transmitted Infections;Women's Health Research

ORG_CITY: LA JOLLA

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE: Bacterial vaginosis is an imbalance of the vaginal flora that occurs in 1/3 of U.S. women and is associated with preterm birth and other reproductive complications. Successful completion of this project will result in a molecular understanding of the role played by specific subtypes of Gardnerella in the pathophysiology of BV and will help identify biomarkers that may be useful predictors of preterm birth.

PI_NAMEs: LEWIS, AMANDA L. (contact);LEWIS, WARREN G

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: adverse outcome;Bacteria;Bacterial Vaginosis;Binding;Biochemical;biomarker identification;biomarker validation;Categories;Clinical;Clinical Data;Collection;Communities;Consumption;Data;Development;Disease;DNA Sequence;dysbiosis;Enzymes;Epithelial Cells;Epithelium;Excision;experience;experimental study;Feeds;Functional disorder;Funding;Gardnerella;Gardnerella vaginalis;Genes;Genetic;Growth;Human;human model;In Vitro;intrauterine infection;Lactobacillus;Longitudinal cohort;Measures;metaplastic cell transformation;microbial;microbiome;Modeling;Molecular;mouse model;Mucous body substance;Mus;mutant;Mutate;Neuraminidase;novel;Paper;pathogen;Pathogenesis;Phenotype;Play;Polysaccharides;Pregnancy Complications;Pregnant Women;Premature Birth;prevent;Publishing;repository;reproductive;Reproductive Tract Infections;Ribosomal RNA;Risk;Role;Sampling;Sialic Acids;Specimen;Stretching;Swab;Taxonomy;Testing;tool;Vagina;vaginal infection;vaginal microbiota;Woman

PROJECT_TITLE: Roles of sialidase in G. vaginalis-host interactions during bacterial vaginosis

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Suicide;Suicide Prevention

PHR: High rates of trauma in Native American communities compromise parents’ mental health and parenting capacity, increasing their children’s risk for substance use and suicide over the life course. We will evaluate a culturally tailored evidence-based intervention named “Wa’ Kan ye’ zah (Little Holy One) to break cycles of intergenerational trauma, with Fort Peck Assiniboine and Sioux parents and their Head Start children.

PI_NAMEs: BROCKIE, TERESA  (contact)

PROJECT_TERMS: 5 year old;active control;active control group;Address;Adolescence;Adolescent;Adverse event;Affect;Age;Behavior;Behavioral;behavioral health;behavioral outcome;Caregivers;Child;Child Development;Child Rearing;Child Welfare;Cognitive Therapy;commune;Communities;Community Health Aides;Community Participation;design;Development;Discipline;disorder prevention;early childhood;Educational process of instructing;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Elements;Emotional;empowerment;Ensure;evidence base;Evidence based intervention;experience;Experimental Designs;externalizing behavior;Family;Funding;Future;Goals;Head Start Program;Health;health disparity;Health Promotion;improved;Indigenous;indigenous community;Individual;Informal Social Control;innovation;intergenerational;Intervention;Learning;Life;Life Cycle Stages;Mental Depression;Mental Health;Names;National Institute of Drug Abuse;National Institute on Minority Health and Health Disparities;Native American community;Native American population;Native Americans;nutrition education;Outcome;parenting intervention;Parents;Participant;patient engagement;peer;Personal Satisfaction;Phase;prevent;preventive intervention;Problem behavior;protective factors;Randomized;Randomized, Controlled Trials;Readiness;reduce symptoms;Research;Research Personnel;Risk;Risk Factors;Self-Injurious Behavior;Sioux Indians;Stress;stress reduction;Substance abuse problem;substance use;substance use prevention;suicidal risk;Suicide;Symptoms;teacher;Testing;Training Programs;Translational Research;Trauma;trial design;tribal community;Tribes;Trust;uptake;Work;young adult;Youth

PROJECT_TITLE: Wa'Kan Ye'Zah: Enhancing caregivers' and children's well-being through an evidence-based and culturally informed prevention intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HDM-V(51)R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Narrative This proposal seeks (through “drug repurposing”) a novel drug therapy as a potential treatment for hippocampal sclerosis dementia. There is no current treatment for this disease that affects approximately 1/4th of the elderly but which is seldom recognized clinically because it mimics Alzheimer's disease. As such, the proposed study represents a cutting-edge, data-driven, low-cost, exploration of a novel disease relevant pathway that may hold promise for our global efforts targeting late life dementia.

PI_NAMEs: JICHA, GREGORY A (contact);NELSON, PETER T.

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: 3-Dimensional;ABCC9 gene;Affect;Age;Aging;aging biomarker;aging mechanism;aging population;Agonist;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;arterial spin labeling;Autopsy;Biological Assay;Biological Markers;biomarker validation;Brain;Cardiovascular system;Clinical;Clinical Trials;Cognition;cognitive testing;cohort;Complement;Congestive Heart Failure;cost;Data;Degenerative Disorder;Dementia;design;Diagnosis;Differential Diagnosis;Diffusion Magnetic Resonance Imaging;Disease;disease diagnosis;Double-Blind Method;drug discovery;drug repurposing;early phase clinical trial;efficacy outcomes;Elderly;Future;Genes;Genetic;genetic risk factor;Heart failure;high risk;hippocampal atrophy;hippocampal sclerosis;Hippocampus;Human;Impaired cognition;Individual;Kentucky;late life;Life;Link;Longitudinal cohort;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Magnetic Resonance Spectroscopy;Measures;Metabolic;Morbidity - disease rate;Nerve Degeneration;Neurocognitive;neurocognitive test;Neurofibrillary Tangles;neuroimaging;neuropathology;Nicorandil;novel;novel therapeutics;Outcome Measure;Participant;Pathology;Pathway interactions;Persons;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phase;Placebo Control;Placebos;Population;Populations at Risk;prevent;Prevention trial;primary endpoint;primary outcome;Probability;Prospective cohort;Proteins;Proteomics;Publishing;Randomized;randomized placebo-controlled clinical trial;rational design;receptor;Research;Risk;Running;Safety;safety testing;sex;tau Proteins;tau-1;Techniques;Testing;treatment duration;trial design;Universities;Urea;volunteer;Work

PROJECT_TITLE: Safety and modulation of ABCC9 pathways by nicorandil for the treatment of hippocampal sclerosis of aging (SMArTâHS)


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: MEMPHIS

ORG_NAME: MEMPHIS VA MEDICAL CENTER

ORG_STATE: TN

PHR: Chronic kidney disease is very common among US veterans and is associated with high morbidity, mortality, and healthcare costs. The proposed research will result in the identification of interventions with potentially significant effects towards preventing CKD in the general VA population and/or decreasing mortality and clinical events among veterans with established CKD, overall and in racial minorities. These results are critical for primary and secondary prevention efforts to reduce the risk and impact of CKD, especially in high-groups such as racial minorities.

PI_NAMEs: KOVESDY, CSABA PAL (contact)

PROJECT_TERMS: Address;adverse outcome;Affect;African American;African American population;Algorithms;Anemia;Biochemical;Biological;bone;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;Caring;Chronic Kidney Failure;Clinical;clinical application;clinical practice;Clinical Trials;cohort;combinatorial;Complex;Computer software;computing resources;Coronary heart disease;Data;Data Analyses;data de-identification;Data Set;Databases;demographics;Development;Diabetes Mellitus;Disease;Disease Progression;Disparity;End stage renal failure;epidemiology study;Equitable healthcare;Ethnic Origin;Event;follow-up;Formularies;Future;General Population;Graph;Guidelines;Health Care Costs;health disparity;Health Expenditures;Health Priorities;Hemoglobin;Hepatitis C;hypercholesterolemia;Hyperlipidemia;Hypertension;Hyperuricemia;Individual;Intervention;intervention effect;Intervention Trial;iron deficiency;Kidney;Kidney Diseases;Leadership;Metabolic;Metabolic acidosis;Minerals;Modality;Morbidity - disease rate;mortality;Obesity;Outcome;patient population;patient subsets;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phosphorus;Population;prevent;Primary Prevention;Process;Publications;Race;racial disparity;racial minority;Randomized, Controlled Trials;Renal function;Research;Risk;Risk Factors;Risk Reduction;Secondary Prevention;sociodemographics;Stroke;Subgroup;supercomputer;Techniques;tertiary prevention;Testing;Therapeutic Intervention;Thrombophilia;Time;treatment and outcome;treatment guidelines;United States National Institutes of Health;Veterans;Work

PROJECT_TITLE: Therapeutic Interventions to Access Outcomes and Disparities in Chronic Kidney Disease Among Veterans

STUDY_SECTION_NAME: HSR-3 Healthcare Informatics[HSR3]


ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Messenger RNAs are the current most promising vaccine strategy for inducing high-titered and long-lasting antibody responses. This IPCAVD Program has the potential to change the field with a successful first in man Phase I clinical trial of trivalent ADCC mosaic mRNAs by showing the plausibility of initiation of high-titered and durable polyfunctional NNAbs that can protect from HIV-1 infection.

PI_NAMEs: HAYNES, BARTON F. (contact)

PROGRAM_OFFICER_NAME: PENSIERO, MICHAEL N

PROJECT_TERMS: Address;Algorithms;aluminum sulfate;ALVAC;Animals;Antibodies;Antibody Response;antibody-dependent cellular phagocytosis;Antigens;B-Lymphocytes;Binding;Cell Lineage;Contracts;Data;design;efficacy trial;Encapsulated;expectation;experimental study;first-in-human;Formulation;Goals;Good Manufacturing Process;Grant;HIV;HIV Envelope Protein gp120;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;homologous recombination;Human;Immunization;immunogenic;improved;in silico;in vivo;Infection;Investigational New Drug Application;Lead;lipid nanoparticle;Macaca;Macaca mulatta;man;manufacturing organization;Mediating;meetings;Messenger RNA;mosaic;mouse model;neutralizing antibody;new technology;novel;Phase;Phase I Clinical Trials;phase I trial;Production;programs;Proteins;Regimen;response;Risk;RNA vaccination;simian human immunodeficiency virus;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;Testing;Therapeutic;Toxic effect;transmission process;Vaccination;Vaccine Design;vaccine development;vaccine efficacy;vaccine strategy;vaccine trial;Vaccines;Work;Writing

PROJECT_TITLE: Messenger RNA Immunogens for initiation of protective HIV non-neutralizing antibodies


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Acceleration;Accounting;Advisory Committees;Agreement;ALVAC;Animal Model;Antibodies;Antigens;B-Lymphocytes;Budgets;Cell Lineage;Clinical Trials;Communication;conflict resolution;Contracts;Data;Data Analyses;data management;Data Provenance;data sharing;Development;Ensure;expectation;Expenditure;experience;Experimental Designs;Funding;Goals;Good Manufacturing Process;Grant;Guidelines;HIV;HIV-1;HIV-1 vaccine;Human;Human Resources;IACUC;Immune response;Infrastructure;Institution;Institutional Policy;interest;Lead;manufacturing organization;Materials Testing;Measures;meetings;member;Messenger RNA;Monitor;Occupational activity of managing finances;Outcome;Participant;Phase I Clinical Trials;Policies;Practice Guidelines;Preparation;Production;programs;Protocols documentation;Publications;quality assurance;Regulation;Reporting;Research;Research Personnel;Resources;Rights;Risk;Supervision;Testing;United States Food and Drug Administration;United States National Institutes of Health;Universities;vaccine platform;Vaccine Research

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adjuvant;Affinity;aluminum sulfate;ALVAC;Antibodies;Antibody Response;Antibody titer measurement;antibody-dependent cell cytotoxicity;antibody-dependent cellular phagocytosis;Antigens;B-Lymphocytes;Binding;CD4 Positive T Lymphocytes;Cells;comparative;Complement;Complex;cost;cytokine;Data;design;Development;efficacy trial;Elements;Epitopes;expectation;follow-up;Grant;Helper-Inducer T-Lymphocyte;HIV;HIV Antibodies;HIV Envelope Protein gp120;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Immune;immune RNA;Immunize;Immunoglobulin Class Switching;improved;Infectious Agent;Inflammatory;innovation;Interferon Type I;Intramuscular;Knock-in Mouse;lipid nanoparticle;Macaca;Macaca mulatta;Maintenance;manufacture;Mediating;Memory B-Lymphocyte;Messenger RNA;MF59;mosaic;mRNA delivery;mRNA lipid nano particle vaccine;Mus;Natural Killer Cells;neutralizing antibody;nonhuman primate;novel vaccines;Nucleosides;Phase;Phase I Clinical Trials;Plasma;Production;Proteins;Rectum;response;Risk;RNA vaccination;RNA vaccine;Safety;sensor;simian human immunodeficiency virus;Structure of germinal center of lymph node;T cell response;Testing;therapeutic protein;Translations;transmission process;vaccine candidate;Vaccine Design;vaccine development;vaccine efficacy;vaccine platform;vaccine trial;Vaccines;Wild Type Mouse;Zika Virus

PROJECT_TITLE: Project 1 - Development of mRNA Immunogens for Protective Antibody Induction


PI_NAMEs: DENNY, THOMAS  (contact)

PROJECT_TERMS: Acceleration;Address;ALVAC;Animal Model;Animals;Antibodies;Antibody Response;Antigens;B-Lymphocytes;Categories;cGMP production;Characteristics;Chemicals;Clinic;Clinical Research;Clinical Trials;Complex;Consumption;Contracts;cost effectiveness;design;Development;Dose;Ensure;env Gene Products;expectation;falls;flexibility;Goals;Grant;HIV;HIV envelope protein;HIV Envelope Protein gp120;HIV vaccine;HIV-1;Human;Immunity;Immunization;immunogenicity;Knowledge;lipid nanoparticle;manufacture;manufacturing organization;Messenger RNA;mosaic;Mus;Nature;neutralizing antibody;nonhuman primate;novel;novel vaccines;Nucleic Acids;Nucleosides;Performance;Pharmaceutical Preparations;Phase;Phase I Clinical Trials;plasmid DNA;Positioning Attribute;Pre-Clinical Model;preclinical study;Process;Production;programs;Proteins;Recombinants;Regimen;research clinical testing;RNA;RNA vaccination;RNA vaccine;Safety;stability testing;System;T cell response;Technology;Testing;Time;timeline;Toxic effect;Toxicology;vaccine candidate;Vaccine Design;vaccine platform;vaccine strategy;Vaccines;vector;Viral Vector;Work;Zika Virus;Zika virus vaccine

PROJECT_TITLE: Project 2 - GMP Manufacturing of mRNA Immunogens


NIH_SPENDING_CATS: HIV/AIDS;Immunization;Prevention;Vaccine Related;Vaccine Related - AIDS


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

ORG_CITY: BIRMINGHAM

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE: Crucial understanding of the molecular mechanism involved in the regulation of bone cell maturation has significant potential for developing interventional therapies in growth anomalies and metabolic bone disorders. Findings from this study will help us in understanding the pathophysiology of skeletal tissues and cartilage and bone disorders.

PI_NAMEs: JAVED, AMJAD  (contact)

PROGRAM_OFFICER_NAME: NICKS, KRISTY

PROJECT_TERMS: Address;Affinity;Anatomy;Animals;Biochemical;Biological;Biological Availability;Biological Process;Biology;BMP2 gene;bone;bone cell;Bone Diseases;Bone Matrix;Bone Morphogenetic Proteins;bone repair;Calvaria;Cartilage;Cartilage Diseases;Cell Differentiation process;Cell Maturation;Cell model;Cells;Chondrocytes;Chromatin;Cleidocranial Dysplasia;Competence;Complex;Cues;Data;Development;DNA Binding;DNA Binding Domain;Embryo;embryo tissue;Erinaceidae;Event;experimental study;Failure;Family;Functional disorder;Gene Deletion;Gene Expression;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;Growth;Human;improved;In Situ Hybridization;in vivo;Inherited;Innovative Therapy;insight;interdisciplinary approach;Intervention;intramembranous bone formation;Knockout Mice;Knowledge;Link;Maintenance;Mammals;MAP Kinase Gene;Mediating;Mesenchymal;Messenger RNA;Metabolic Bone Diseases;mineralization;Modeling;Modification;Molecular;Molecular Biology;Monitor;morphogens;Mus;Mutagenesis;mutant;Mutation;novel;Null Lymphocytes;osteoblast differentiation;Osteoblasts;Osteogenesis;Osteogenesis Imperfecta;osteogenic;osteogenic protein 2;osteoprogenitor cell;Pathway interactions;Pattern;Phenotype;Physical assessment;Physiologic Ossification;Post-Translational Protein Processing;posttranscriptional;prevent;Process;Protein Biochemistry;protein function;Proteins;RBX1 gene;reconstitution;recruit;Regulation;repaired;Research;RNA;Role;Runx2 protein;Signal Transduction;skeletal;Skeletal Development;skeletal disorder;skeletal tissue;skeletogenesis;Skeleton;Specific qualifier value;Specificity;stable cell line;Subgroup;Sumoylation Pathway;Testing;Therapeutic Intervention;therapy development;Tissues;Tooth eruption;transcription factor;transcription regulatory network;ubiquitin ligase;ubiquitin mediated proteasome degradation;Vertebrates;Zinc Fingers

PROJECT_TITLE: Sp7 Mediated Control of Runx2 Function for Osteoblast Differentiation

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Aging;Clinical Research;Health Services;Physical Injury - Accidents and Adverse Effects;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative The goal of this R01 application is to examine time trends for incident fall injuries in Medicare, including non- fracture fall injuries (NFFI) and fractures, across 20 years of cohort data and if changes in key risk factors of metabolic and neuromuscular function over the time period explains trends; and then evaluate major geriatric outcomes subsequent to NFFI in a pooled cohort of nearly 12,000 older adults (61% women, 33% minorities, 36% aged >80 years, 27% obese). Incident fracture and NFFI, defined as fall injuries without prior fracture, will be identified from 5-10 years of self-reported questions and Medicare Fee for Service (FFS) Parts A and B claims; and then incident NFFI will be related to subsequent inpatient hospitalizations, skilled nursing facility (SNF) stays and mortality for up to 5 years after NFFI. Our validated approach from past projects will pool extensive cohort data and Medicare claims to evaluate fall injury trends, including clinical NFFI, as a public health issue in aging.

PI_NAMEs: STROTMEYER, ELSA S. (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Adult;Age;age group;aged;Aging;beneficiary;Blood Pressure;Body Composition;cardiovascular health;Cessation of life;Clinical;cohort;Cohort Studies;cost;Data;Diabetes Mellitus;disability;Elderly;Epidemiology;Event;fall injury;falls;Fee-for-Service Plans;Fracture;Future;Gait speed;Goals;Hand Strength;Health;health care service utilization;Health Personnel;Hospitalization;human old age (65+);Incidence;Injury;Inpatients;Link;Long-Term Care;Longitudinal cohort;Medical;Medicare;Medicare claim;men;Metabolic;Minority;mortality;neuromuscular;neuromuscular function;novel;Obesity;older adult;older men;older women;osteoporosis with pathological fracture;Outcome;Outpatients;Participant;participant enrollment;Pathway interactions;Patient Self-Report;Persons;Prevention Guidelines;Public Health;Recording of previous events;Risk;Risk Factors;Skilled Nursing Facilities;Soft Tissue Injuries;Speed;Time;Time trend;trend;Woman;Women's Health;Work

PROJECT_TITLE: Non-Fracture Fall Injuries and Long-Term Geriatric Consequences in Older Women and Men from a Cross-Cohort Study

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Neurodegenerative;Neurosciences;Parkinson's Disease;Rehabilitation

ORG_CITY: DALLAS

ORG_DEPT: NEUROSURGERY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Although general anesthesia is used everyday to enable surgical care, brain mechanisms for inducing loss of consciousness are not well understood. The goal of this proposal is to use neurosurgical opportunities in humans to gain insight into the systems-level neurophysiological basis of anesthesia and consciousness, with greater spatial, temporal, and spectral resolution and confidence than can be achieved in animal or computational models. This work will explicitly test the mesocircuit theory of consciousness in humans to better characterize the complex interplay and causal relationships between cortical and subcortical networks, expanding the knowledgebase that is critical for developing, optimizing, and monitoring anesthetics.

PI_NAMEs: POURATIAN, NADER  (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Affect;Amnesia;Anesthesia procedures;Anesthetics;Animal Model;Animals;Area;Arousal;Basal Ganglia;Basal Ganglia Diseases;Behavioral;behavioral response;Binding;Brain;brain behavior;Brain imaging;Brain Injuries;Caring;Characteristics;Clinical;cohort;Complex;Computer Models;Conscious;Consciousness Disorders;Corpus striatum structure;Deep Brain Stimulation;Disinhibition;Dose;Drug Kinetics;dynamical evolution;EEG-based imaging;Essential Tremor;Evolution;Excessive Daytime Sleepiness;experience;Experimental Models;Functional disorder;gamma-Aminobutyric Acid;General Anesthesia;Globus Pallidus;Goals;Human;human data;human subject;Hypnosis;implantation;Infusion procedures;injury recovery;innovation;insight;Interdisciplinary Study;Investigation;knowledgebase;Measures;Mediating;Mediation;Modeling;Molecular;Monitor;Movement;Nervous System Disorder;neural circuit;neurophysiology;neurosurgery;Operative Surgical Procedures;Output;Parkinson Disease;Pathology;patient population;Patients;Persons;Pharmacodynamics;pharmacologic;Physiology;programs;Propofol;Recovery;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resolution;response;Role;Severity of illness;Sleep Disorders;System;Testing;Thalamic structure;theories;Time;Unconscious State;Variant;Work

PROJECT_TITLE: Cortical-Subcortical Network Dynamics of Anesthesia and Consciousness

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Autism;Brain Disorders;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Establishment and maintenance of long axonal projections and synapses are essential for the development and function of the central nervous system. However, the cellular mechanisms underlying proper axon elongation, integrity, and synapse formation and function are not clear, but ankyrin-B, a membrane cytoskeleton-associated protein, is likely to be a key contributor to these processes. The studies proposed in this grant aim to understand the isoform-specific roles of ankyrin-B in axonal development and connectivity in the nervous system. This may illuminate the etiology of neurological disorders caused by aberrant white matter structural development and connectivity and synaptic deficits in which ankyrin-B plays a role.

PI_NAMEs: LORENZO, DAMARIS N (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Adult;Affect;Anatomy;ANK2 gene;Ankyrins;ASD patient;autism spectrum disorder;Axon;axon growth;axon guidance;Axonal Transport;Binding;Biochemical;Biological Assay;Brain;Brain Diseases;Brain region;Cell Adhesion Molecules;Cell Physiology;Cells;Central Nervous System;Complex;Corpus Callosum;Couples;Cytoskeleton;Data;de novo mutation;Defect;density;Development;Disease;dynactin;Etiology;Failure;Functional disorder;Gene Delivery;gene network;Glutamates;Goals;Grant;Growth;Human;Impairment;in utero;In Vitro;in vivo;Knock-out;Knockout Mice;Length;Maintenance;Mediating;Membrane;Mental disorders;Metabotropic Glutamate Receptors;Microtubules;morphometry;Motility;Motor;mouse model;Mus;mutant;Mutation;Nervous System;Nervous System Disorder;Neural Cell Adhesion Molecule L1;Neurodegenerative Disorders;Neurodevelopmental Disability;Neurologic;neuron development;neuron loss;Neurons;neurotransmission;novel;Parkinson Disease;Pathway Analysis;Patients;Phenotype;postnatal period;postsynaptic;prenatal;Process;Protein Isoforms;Proteins;receptor;Regulation;Research;Role;Schizophrenia;Semaphorin-3;Signal Transduction;Somatosensory Cortex;Specific qualifier value;Spectrin;Structure;superresolution imaging;Synapses;synaptic function;synaptic pruning;Synaptic Transmission;synaptogenesis;Testing;trafficking;transmission process;Variant;Vertebral column;Vesicle;white matter

PROJECT_TITLE: Role of Ankyrin-B in the Nervous System

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Digestive Diseases;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: MADISON

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: The proposed research will advance our understanding of underlying mechanisms linking intestinal lipid processing and bile acid metabolism with pancreatic islet function. This work will both increase our knowledge about how metabolism of a key macronutrient influences systemic metabolic health as well as provide insights into potential preventive or therapeutic interventions for obesity and diabetes.

PI_NAMEs: YEN, CHI- LIANG ERIC  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 2-acylglycerol O-acyltransferase;absorption;Acyl Coenzyme A;Affect;Alpha Cell;Antibiotics;Apical;ASBT protein;B-Lymphocytes;Beta Cell;bile acid metabolism;Bile Acids;bile salts;Cecum;Cells;Chemicals;combat;Communication;Compensation;Development;Diabetes Mellitus;Diabetic mouse;Diet;Dietary Fats;Digestion;Disease;endoplasmic reticulum stress;energy balance;Energy Metabolism;Environment;Enzymes;Epidemic;Escherichia coli;Exhibits;Failure;Fatty acid glycerol esters;feeding;GCG gene;Genes;Germ-Free;GLP-I receptor;glucagon-like peptide 1;glycemic control;Goals;gut microbiota;Health;Health Care Costs;healthcare burden;Hormones;Human;Hydrolase;Hyperglycemia;improved;inhibitor;insight;Insulin;Insulin Resistance;insulin secretion;Intervention;Intestinal Absorption;Intestines;islet;Islets of Langerhans;Isotopes;Knowledge;Life;Ligands;Link;Lipids;Macronutrients Nutrition;Mediating;Membrane;Metabolic;Metabolic Diseases;Metabolism;microbial;Molecular;Morphology;muricholic acid;Mus;Natural regeneration;Non-Insulin-Dependent Diabetes Mellitus;novel;Nuclear Receptors;Obesity;obesity treatment;Organ;overexpression;Pancreas;pancreatic islet function;pancreatic juice;Pathway interactions;Patients;Pharmacologic Substance;Physiological;Plasma;Predisposition;preservation;Prevalence;prevent;Prevention;preventive intervention;Process;productivity loss;proglucagon;protective effect;Qualifying;receptor;Receptor Signaling;receptor-mediated signaling;Reporting;Research;Resistance;Resources;Role;Signal Pathway;Signal Transduction;Societies;Sodium;Streptozocin;Structure of alpha Cell of islet;Structure of beta Cell of islet;Taurocholic Acid;Testing;Therapeutic Intervention;Tissues;Toxin;Tracer;Triglycerides;United States;Ursodeoxycholic Acid;Wild Type Mouse;Work

PROJECT_TITLE: Intestinal Lipid Processing, Bile Acid Metabolism, and Pancreatic Islet Function

STUDY_SECTION: INMP

STUDY_SECTION_NAME: Integrative Nutrition and Metabolic Processes Study Section[INMP]


ED_INST_TYPE: HOSPITALS

ORG_CITY: HOUSTON

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE Although immunotherapy has dramatically shifted clinical outcomes for some cancer patients, most non-small cell lung cancer patients fail to receive significant benefit, highlighting the urgent need to identify barriers to successfully harnessing the immune system to eradicate tumors. Recent work suggests a subset of CD8 T cells that expresses the transcription factor TCF-1 is associated with better responses to immunotherapy, but our understanding of how these cells develop and how to promote their production is limited. The main goal of this proposal is to further characterize this TCF-1+ CD8 T cell population in a mouse model of NSCLC, with a specific focus on their ontogeny, how they lose their function over the course of tumorigenesis, and how to promote their accumulation in situations where their numbers are limiting.

PI_NAMEs: SCHENKEL, JASON M. (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Address;Anatomy;Antigens;Antitumor Response;Attention;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cell Communication;Cell Compartmentation;Cells;Chronic;chronic infection;Clinical;CXCR3 gene;cytokine;cytotoxic;Data;Development;Dissection;draining lymph node;effector T cell;Functional disorder;Genetic Transcription;Goals;Growth;Heterogeneity;Human;Immune;Immune system;Immune Targeting;Immunity;Immunotherapy;improved;in vivo;Indolent;Infection;Infiltration;KRAS2 gene;Label;Location;Lung;Lung Adenocarcinoma;lymph nodes;Lymphocytic choriomeningitis virus;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Methodology;migration;Modeling;mouse model;Mus;mutant;Neoplasm Transplantation;neoplastic cell;Non-Small-Cell Lung Carcinoma;novel therapeutics;Outcome;Parabiosis;pathogen;patient subsets;Patients;Pattern;PD-1 inhibitors;Phenotype;Physiological;Play;Population;Positioning Attribute;pressure;Production;Productivity;Proliferating;Property;response;restraint;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Site;success;Surveys;System;T cell response;T cell transcription factor 1;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;Time;Touch sensation;trafficking;transcription factor;transcriptomics;Treatment outcome;tumor;tumor eradication;tumor initiation;tumor progression;tumorigenesis;Work

PROJECT_TITLE: The ontogeny and function of CD8 T cells in lung cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Tsetse fly transmitted diseases caused by African trypanosomes devastate public health in Africa because of lack of mammalian vaccines, cheap and oral therapeutic drugs. Reducing tsetse vector populations or blocking parasite transmission in tsetse provides alternative tools for disease control. Understanding the tsetse-trypanosome dialogue during the infection process is paramount to developing methods to block parasite transmission in tsetse, which we investigate in this application.

PI_NAMEs: AKSOY, SERAP  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Affect;Africa;African;African Trypanosomiasis;Anabolism;Animals;Biological Assay;Biology;Blood;Bolus Infusion;Bypass;Cell Line;co-infection;combat;Data;design;Disease;disease transmission;disorder control;Epidemiology;Epithelium;experimental study;Feeds;fly;Foundations;functional genomics;Genetic Transcription;Genomics;Goals;Health;Human;Immune;In Vitro;in vivo;Infection;innovation;Insecta;Interdisciplinary Study;Investigation;Knowledge;Knowledge acquisition;Laboratories;Luciferases;Mammals;Mediating;Mediator;Membrane;Membrane Glycoproteins;Membrane Proteins;Messenger RNA;Methods;MicroRNAs;Midgut;migration;Modification;Molecular;Molecular Target;neglect;novel;Oral;Organ;Parasites;Parasitic infection;paratransgenesis;Pathway interactions;Pharmaceutical Preparations;Physiology;Polysaccharides;Population;Prevalence;Prevention;Process;Proteins;Proventriculus;Public Health;Regulatory Pathway;ribosome profiling;Role;Sahara;Saliva;Salivary Glands;Scientist;Shapes;Signal Pathway;stomach cardia;Stream;Structure;success;Surface;System;Testing;Therapeutic;tool;transcriptome;transcriptomic profiling;transcriptomics;Transgenic Organisms;transmission blocking;transmission process;Trypanocidal Agents;Trypanosoma;Tsetse Flies;uptake;Vaccines;Variant;vector;vector competence;vector control

PROJECT_TITLE: Molecular Aspects of Tsetse and Trypanosome Transmission

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Prevention;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE Particularly for socioeconomically disadvantaged adults, unemployment can trigger a cascade of stress-related coping and behavioral processes that increase risk factors for chronic disease. Many in this population (1) depend on social services-related employment programs that assist with securing jobs but do not address the heightened health risks that accrue during this period, and then (2) move into workplace environments where supervisor experiences can exacerbate or perpetuate these risks. Interventions to mitigate chronic disease risks while in employment programs at the individual level, and to provide supervisory supports at the employer level could have a positive, cumulative impact on reducing health inequities within communities.

PI_NAMEs: KNEIPP, SHAWN MARIE (contact)

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: Acceleration;Acute;Address;Adopted;Adult;Affect;Area;arm;Awareness;Behavior;Behavioral;Blood Pressure;blood pressure elevation;burden of chronic illness;Chronic Disease;Client;clinically relevant;Coin;Collaborations;Communities;community academic partnership;community partners;comorbidity;comparison intervention;coping;Cost Effectiveness Analysis;design;Development;disorder prevention;disorder risk;Economic Development;economic evaluation;Economically Deprived Population;Education;effectiveness testing;Employment;Ensure;Equilibrium;ethnic minority;Ethnic Origin;Evidence based intervention;experience;Fostering;Goals;Health;Health behavior;health determinants;health inequalities;Healthcare Systems;high risk;Hypertension;implicit bias;improved;Income;Individual;Inequity;innovation;Instruction;Intervention;Investments;Job loss;Joints;Life Style;Marketing;Minor;Mission;Morbidity - disease rate;mortality;National Institute on Minority Health and Health Disparities;Occupations;Onset of illness;Outcome;Phase;Population;population health;Population Programs;Prevention;Prevention program;primary outcome;Process;professional atmosphere;programs;psychologic;psychological distress;Public Assistance;Public Health;Public Health Practice;Race;racial minority;Randomized;Reduce health disparities;Research;Research Personnel;Risk;Risk Factors;Science;secondary outcome;Secure;Services;skills;social determinants;social health determinants;Social Work;socioeconomic disadvantage;Socioeconomic Status;sound;State Government;Stress;Stress and Coping;structural determinants;Structure;Supported Employment;Target Populations;Testing;Time;Training;Unemployment;Weight Gain;welfare;Workplace

PROJECT_TITLE: NC Works4Health: Reducing Chronic Disease Risks in Socioeconomically Disadvantaged, Unemployed Populations

STUDY_SECTION: HDEP

STUDY_SECTION_NAME: Health Disparities and Equity Promotion Study Section[HDEP]


ORG_DEPT: ORTHOPEDICS

PHR: Joint cartilage symptoms affect 1/3 of adults in the US, comprise the leading cause of disability, and current therapies to treat the destroyed cartilage are seriously limited. We have developed novel nanofibrous hollow microspheres as an injectable carrier for minimally invasive cartilage repair. This project will develop a new cell-free approach utilizing the novel injectable carrier and biomolecule delivery strategy to activate host stem cells to regenerate cartilage.

PI_NAMEs: MA, PETER X;SCHIPANI, ERNESTINA  (contact)

PROGRAM_OFFICER_NAME: MARQUITZ, ARON

PROJECT_TERMS: Adopted;Adult;Affect;arthropathies;Autologous;bHLH-PAS factor HLF;Biochemical;Biological;biomechanical test;Biomimetics;Bone Marrow;Cartilage;cartilage degradation;cartilage regeneration;cartilage repair;Cell Differentiation process;Cell Therapy;Cells;Chondrocytes;Chondrogenesis;Clinic;controlled release;Defect;disability;Dose;Engineering;Environment;Extracellular Matrix;Family;Formulation;gain of function;Genetic Transcription;Glycolates;Histologic;Human;Hyaline Cartilage;Hyperostosis;Hypertrophy;Hypoxia;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immobilization;implantation;In Situ;In Vitro;in vivo;Injectable;Joints;Lactic acid;loss of function;member;Microspheres;mimetics;minimally invasive;Modeling;Molecular;Mus;nano;nanofiber;Nanosphere;Natural regeneration;novel;novel strategies;Nude Mice;Oryctolagus cuniculus;osteochondral repair;osteochondral tissue;Oxygen;patient population;Population;prevent;Prevention;Procedures;Regulation;repair model;repaired;Role;self assembly;Shapes;Signal Transduction;Specificity;Stains;Standardization;stem cells;Stromal Cells;subcutaneous;Supporting Cell;Symptoms;synergism;System;Techniques;Technology;Testing;Time;time use;Tissue Engineering;Tissues;transcription factor;Transforming Growth Factor beta;Trauma;wound

PROJECT_TITLE: Regenerating Hyaline Cartilage Using Nanofibrous Hollow Microspheres and Synergizing TGF-beta and HIF

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: TUSCALOOSA

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF ALABAMA IN TUSCALOOSA

PHR: Project Narrative This project has the potential for critical public health outcomes: (a) reducing youth violence, particularly related to race, (b) improving school climate and (c) improving teacher practices regarding discipline, racism, and discrimination in public schools.

PI_NAMEs: LOCHMAN, JOHN E;MCDANIEL, SARA  (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;African American population;African American student;Age;Aggressive behavior;Alabama;Behavioral;Caregivers;Cause of Death;Child;Cognitive;cohort;Color;Communities;coping;criminal behavior;Data;Development;Discipline;Discrimination;educational atmosphere;effective intervention;eighth grade;Emotional;ethnic minority population;evidence base;Exposure to;externalizing behavior;Failure;follow-up;Homicide;Hylobates Genus;implicit bias;Imprisonment;improved;Individual;Intervention;junior high school;Letters;Measures;Middle School Student;Modeling;Outcome;parental involvement;parenting intervention;Population;Poverty;Prevalence;Prevention;Prevention strategy;preventive intervention;Price;Public Health;Race;racial bias;racial discrimination;racial identity;racial minority population;racism;Randomized;Randomized, Controlled Trials;recruit;reduce youth violence;Risk;Risk Factors;Risk Reduction;Schools;screening;social;Source;stressor;Students;teacher;Training;United States National Institutes of Health;Victimization;Violence;violent crime;Well in self;Youth;youth violence;youth violence prevention

PROJECT_TITLE: Reducing Youth Violence and Racism/Discrimination: The Efficacy of Comprehensive Prevention Strategies (CPS)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: COLLEGE STATION

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PI_NAMEs: SAMUEL, JAMES EVANS (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Agonist;ANK2 gene;Ankyrin Repeat;Autoimmune Diseases;Bacteria;Binding;Bone Marrow;cancer therapy;Cell Culture Techniques;Cell Nucleus;Cells;Characteristics;Chronic;Complement;Coxiella;Coxiella burnetii;Data;Disease;Genes;Genetic;Genetic Transcription;Goals;Human;IL17 gene;Immune response;Immune signaling;In Vitro;in vivo;Infection;Inflammatory;innate immune function;knock-down;Knock-out;Lysosomes;Macrophage;Macrophage Activation;Maps;metabolomics;Methods;Modeling;Modification;Molecular;monocyte;mutant;Mutation;novel;Nuclear Translocation;Open Reading Frames;Organism;p65;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;permissiveness;Phenotype;Post-Transcriptional Regulation;promoter;Proteins;Q Fever;response;Role;Signal Pathway;Signal Transduction;single cell analysis;Site;Structure;Testing;tool;transcriptome sequencing;transcriptomics;Transfection;Type IV Secretion System Pathway;Vacuole;Virulence;virulence gene

PROJECT_TITLE: Identification and Role of Type IV Secretion Effector Proteins in Coxiella burnetii

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BACP-Y(07)]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Childhood Injury;Clinical Research;Neurosciences;Pediatric;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Unintentional Childhood Injury

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Project Narrative: The neurocognitive effects of concussions in adolescence can have a negative influence on activities of daily living pertinent to adolescent development, such as school, physical activity, and connection with peers. However little research has examined when, how, and what happens when adolescents return to drive after a concussion. To address this critical gap in research and clinical practice, our proposed research integrates Discovery, Translation and Real-world Assessment by examining the neurophysiological functioning of the recovering concussed adolescent brain while managing driving tasks, the association between their neurophysiological functioning and clinical assessments, and the nature of concussed adolescents' engagement in risky driving behaviors.

PI_NAMEs: MCDONALD, CATHERINE CLAIRE (contact)

PROGRAM_OFFICER_NAME: LONG, SYLVIA ELISABETH

PROJECT_TERMS: Accounting;Activities of Daily Living;Address;Adolescence;Adolescent;Adolescent Development;Affect;Automobile Driving;Autonomic Dysfunction;Behavior;Brain;Brain Concussion;Cellular Phone;Cessation of life;Child;Clinical;Clinical assessments;clinical practice;Cognition;Cognitive;cognitive function;cohort;Complex;concussive symptom;Data;driving behavior;driving safety;Ecological momentary assessment;Enrollment;Environmental Risk Factor;Event;evidence base;evidence based guidelines;Foundations;functional near infrared spectroscopy;G Forces;Gait;Goals;Guidelines;Health Promotion;hemodynamics;Impairment;innovation;Licensing;Measures;Methods;mild traumatic brain injury;Monitor;multidisciplinary;Nature;Neurocognitive;Neurocognitive Deficit;neurophysiology;novel;oculomotor;Patient Self-Report;peer;Physical activity;Physiology;Prefrontal Cortex;processing speed;prospective;Public Health;Pupil light reflex;Qualifying;Recommendation;Research;Research Personnel;response;Risk;risky driving;Safety;Schools;Science;simulation;skills;Speed;success;Symptoms;synergism;Technology;Testing;Time;Translating;Translations;Vehicle crash;Visual;Workload

PROJECT_TITLE: Driving after Concussion: Examination of the Adolescent Brain and Behaviors

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Lung

PHR: Project Narrative Viral infection often leads to unregulated inflammatory responses, which contribute to the viral pathogenesis. The proposal will reveal novel anti-inflammatory functions for the host transcription factor IRF3 in modulating immune responses to inflammatory stimulus e.g. respiratory virus infection. The results will lead to deeper understanding of how viral as well as non-viral inflammation is controlled, with potential therapeutic significance.

PI_NAMEs: CHATTOPADHYAY, SAURABH  (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Address;airway epithelium;Alveolar Macrophages;Anti-Inflammatory Agents;Anti-viral Response;Apoptosis;Apoptotic;Binding;Biochemical;cell type;Cells;conditional knockout;Cytosol;design;Dimerization;disease model;domain mapping;Engineering;Epithelial Cells;Exhibits;fatty liver disease;Gene Expression;gene induction;Genes;genetic approach;Genetic Transcription;Goals;Human;Immune response;immunoregulation;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Inflammatory;Inflammatory Response;Influenza;Innate Immune Response;innovation;Interferons;IRF3 gene;Knock-in Mouse;Knockout Mice;Knowledge;Location;LoxP-flanked allele;Lung;Macrophage;Maps;Measures;Mediating;microbial;Microscopic;Modeling;Molecular;mouse model;Mus;mutant;Natural Immunity;non-alcoholic fatty liver disease;novel;Nuclear Translocation;p65;Pathogenesis;Pathway interactions;Phosphorylation;Physiological;Predisposition;prevent;problem drinker;Property;Proteins;Repression;Research;Research Personnel;respiratory infection virus;respiratory virus;response;Role;Sendai virus;Stimulus;Testing;Therapeutic;three dimensional structure;TNF gene;TNFRSF5 gene;transcription factor;Ubiquitination;Viral;Viral Genes;Viral Pathogenesis;Viral Physiology;Virus;Virus Diseases

PROJECT_TITLE: Anti-inflammatory functions for non-transcriptional IRF3

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-T(02)M]


NIH_SPENDING_CATS: Biotechnology;Genetics;Infectious Diseases;Sexually Transmitted Infections

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Over millennia the constant battle between the host and an invading virus has illuminated the different strategies coopted by invading pathogens to overcome cellular defenses. In this application we propose to discover the functions of many so called “redundant” genes and networks that are important for herpes simplex virus type-1 (HSV-1) virion morphogenesis and replication. By taking advantage of novel synthetic biology tools we will use an HSV-1 genome assembly line to interrogate and illuminate the pathways used by the virus to replicate in an otherwise hostile environment.

PI_NAMEs: DESAI, PRASHANT J (contact);VASHEE, SANJAY

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: Biochemical;Biological;Biological Assay;Biology;Blindness;Capsid;Cell Culture System;Cell Culture Techniques;Cells;cellular imaging;chronic infection;Classification;Clinical;combinatorial;Complex;Coupled;Cytoplasm;Data;Defect;Development;Disease;Dissection;DNA Packaging;ds-DNA;efficacious treatment;Electrons;Elements;Encephalitis;Engineering;Environment;experience;Eye diseases;Family;Gene Deletion;gene product;General Population;Genes;Genetic;Genitalia;Genome;genome-wide;Glycoproteins;Goals;Herpes Labialis;Herpesviridae;Herpesvirus 1;human pathogen;imaging modality;Individual;Infection;insight;Invaded;Investigation;Keratitis;Laboratories;Malignant Neoplasms;Mediating;Membrane;Membrane Proteins;Methods;Molecular Genetics;Morphogenesis;mutant;Mutation;Mutation Analysis;neonatal infection;novel;Nuclear;Outcome;particle;pathogen;Pathway interactions;Phenotype;Play;polypeptide;protein complex;protein function;Proteins;Public Health;Publishing;Reiterated Genes;Role;Side;Simplexvirus;Structure;synthetic biology;synthetic genomics;Testing;tool;Viral;viral DNA;Virion;Virus

PROJECT_TITLE: Elucidation of genetic networks of HSV-1 virion proteins and discovery of their functions in the morphogenesis of the infectious virus particle

STUDY_SECTION: VIRA

STUDY_SECTION_NAME: Virology - A Study Section[VIRA]


FUNDING_MECHANISM: OTHERS

ORG_CITY: CLEVELAND

ORG_NAME: LOUIS STOKES CLEVELAND VA MEDICAL CENTER

ORG_STATE: OH

PHR: Professor Tyler’s research mission is to develop devices and technology that connects directly to a veteran’s nervous system. By directly communicating with the nervous system it is possible to address several significant veteran’s health and quality of life issues that cannot or have not been addressed by drugs or other methods. Dr. Tyler specifically focuses on three significant veteran’s needs - limb loss, hypertension, and spinal cord injury. For veteran’s that have lost a limb, Dr. Tyler is developing technology that provides sensation and naturalistic control of advanced prostheses. The veteran feels like they have either their hand or foot again. For veteran’s with high blood pressure unresponsive to medications, Dr. Tyler’s neural technology applied to the carotid sinus nerve is showing promise in controlling blood pressure. In spinal cord injury, Dr. Tyler’s neural technology restores movement and activation to paralyzed limbs. His technology is helping veterans with paraplegia stand and walk and those with quadriplegia to use their hand.

PI_NAMEs: TYLER, DUSTIN J. (contact)

PROJECT_TERMS: Action Potentials;Address;Advanced Development;Animal Experimentation;Area;Award;Baroreflex;Biomedical Engineering;Blood Pressure;blood pressure control;blood pressure regulation;Bluetooth;Brain;career;career development;carotid sinus;Chronic;Clinical;Clinical Research;clinical translation;Clupeidae;Collaborations;Colorado;Communication;Complex;Computational algorithm;computational neuroscience;density;Dermis;design;Development;Devices;Disease;Doctor of Philosophy;Electrical Engineering;Electrodes;Electromagnetics;Elements;Emotional;Engineering;Esthesia;experience;Eye;fabrication;Florida;foot;functional restoration;Funding;Goals;Government;Grant;Hand;Health;Heart Rate;Histologic;Human;Hypertension;hypertension control;Implant;implantation;improved;indexing;Individual;Industry;Injections;Institution;interest;limb loss;Limb structure;Love;Lower Extremity;Medical center;Mentors;Methods;Michigan;Mission;Modeling;Movement;multidisciplinary;Muscle;nanocomposite;nanopolymer;Nerve;Nervous System;Nervous System Disorder;neural;neural implant;Neurologic Deficit;neuroregulation;Neurosciences;next generation;Paper;Paralysed;Paraplegia;Patients;Pattern;Perception;Peripheral;Peripheral Nerve Stimulation;Peripheral Nerves;Peripheral Nervous System;Pharmaceutical Preparations;Pharmacologic Substance;preclinical development;Privatization;professor;programs;Prostheses and Implants;Prosthesis;Quadriplegia;Quality of life;randomized, clinical trials;Rehabilitation therapy;Research;Research Personnel;Research Project Grants;response;restoration;Role;Science;Scientist;Sea Cucumbers;Secure;Seminal;Sensory;sensory feedback;Services;Shapes;skills;Specialist;Spinal cord injury;Stimulus;Stroke;System;Talents;Techniques;Technology;technology development;Thinking;Tissues;Touch sensation;Translational Research;Translations;Upper Extremity;Veterans;Walking;Wife;Work

PROJECT_TITLE: RR&D Research Career Scientist Award Application

STUDY_SECTION_NAME: Research Career Scientist[RRD7]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Cocaine;Drug Abuse (NIDA only);Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: STONY BROOK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: This proposal will apply a novel multimodality optical imaging platform that, when combined with genetically encoded Ca2+ fluorescence indicators of astrocyte and neuronal activities and chemogenetics for astrocytic Ca2+ manipulation, will allow us to assess the effects of cocaine in astrocytes and their role in modulating neuronal and vascular responses to cocaine in the prefrontal cortex (PFC) and their association with cocaine self-administration with repeated exposures. This proposal will also assess the efficacy of astrocytic Ca2+ modulation as an interventional strategy aimed at restoring PFC function and reducing cocaine use.

PI_NAMEs: DU, CONGWU  (contact);PAN, YINGTIAN

PROGRAM_OFFICER_NAME: TSAI, SHANG-YI ANNE

PROJECT_TERMS: 3-Dimensional;Acute;addiction;Affect;Angiography;Animal Model;Animals;Astrocytes;Behavioral;Blood Vessels;Brain;Brain Diseases;Calcium;cerebral hemodynamics;Cerebrovascular Circulation;Cerebrovascular system;Chronic;Cocaine;Cocaine Dependence;cocaine self-administration;cocaine use;Complement;Consumption;designer receptors exclusively activated by designer drugs;Development;Diameter;Doppler tomography;efficacy evaluation;efficacy testing;Fluorescence;fluorescence imaging;Functional disorder;Genetic;genetic approach;Glial Fibrillary Acidic Protein;Hemoglobin;Human;Image;imaging platform;imaging study;Imaging Techniques;Impairment;improved;in vivo;Individual;insight;Intake;Intervention;Ischemia;Knowledge;Measures;Mediating;Modality;Multi-modal optical imaging;Mus;Neuroglia;neuroimaging;Neurons;neurotoxic;neurotoxicity;neurovascular;neurovascular coupling;novel;novel imaging technique;Optics;Paralysed;Pharmaceutical Preparations;Pilot Projects;Play;Prefrontal Cortex;prevent;quantitative imaging;Reporting;Resolution;response;Role;Self Administration;Severities;Techniques;Transient Ischemic Attack;ultra high resolution;vasoconstriction

PROJECT_TITLE: Calcium-related neurotoxicity of cocaine

STUDY_SECTION: PMDA

STUDY_SECTION_NAME: Pathophysiological Basis of Mental Disorders and Addictions Study Section[PMDA]


NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Influenza;Opioid Misuse and Addiction;Opioids;Pneumonia and Influenza;Prevention;Substance Misuse;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Project Narrative This study addresses the immune deficiency in virally suppressed HIV infected chronic opioid users that can lead to failure of an effective response to influenza vaccination. It also provides insight into the functioning of a specialized peripheral blood CD4 T cell subset (pTfh for peripheral T follicular helper cell) that can be of critical importance in facilitating Ab responses to influenza and other vaccines. Understanding the underlying defects in pTfh and other cells that impair the antibody secretion by B cells may lead to development of scientific strategies to optimize vaccine responses, eg to opioid vaccines aimed at curing opioid addiction.

PI_NAMEs: PAHWA, SAVITA  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: addiction;Address;Adult;Affinity;Analgesics;antagonist;Antibodies;Antibody Formation;Antibody Response;Antigens;Area;B-Lymphocytes;Blood specimen;Brain;CD4 Positive T Lymphocytes;Cell Count;Cell Maturation;Cell Physiology;Cells;Cessation of life;Characteristics;Chronic;Cities;Classification;Clinic;Coupled;Dangerousness;Data;Data Set;Defect;delta opioid receptor;Dependence;Development;drug abuser;Epidemic;Evaluation;Exhibits;Failure;Feasibility Studies;Flow Cytometry;flu;Frequencies;Functional disorder;Functional impairment;Future;Generations;Genetic Transcription;Genomic approach;genomic platform;Helper-Inducer T-Lymphocyte;HIV;HIV Infections;HIV Seronegativity;HIV/AIDS;Human;Immune;immune activation;immune function;Immune response;Immune system;Immune System Diseases;Immunity;Immunocompetence;immunodeficiency;Immunoglobulin Somatic Hypermutation;Immunologics;Impairment;In Vitro;Incidence;indexing;Inflammation;Inflammatory;inflammatory marker;Influenza;Influenza A Virus, H1N1 Subtype;influenza infection;Influenza vaccination;influenza virus vaccine;insight;interest;Interleukin-2;interleukin-21;Intervention;Lymphoid;Memory;Memory B-Lymphocyte;Morphine;neglect;novel;Nucleic Acids;Opiate Addiction;Opioid;opioid epidemic;opioid injection;Opioid Receptor;opioid use;opioid user;Participant;Patients;Peripheral;peripheral blood;Personal Satisfaction;Persons;Phenotype;Plasma;Plasmablast;Play;Population;prescription opioid;prevent;programs;Property;receptor;Receptor Signaling;Recovery;recruit;Research;Resolution;responders and non-responders;response;seasonal influenza;Seasons;Serology;Signal Transduction;single cell genomics;single cell technology;Structure of germinal center of lymph node;Subgroup;Surface;T-Lymphocyte Subsets;Technology;Testing;therapeutic vaccine;tool;transcriptomics;trivalent influenza vaccine;Universities;Vaccination;Vaccine Antigen;vaccine response;vaccine-induced antibodies;Vaccinee;Vaccines;Viral

PROJECT_TITLE: Immune Dysfunction in HIV+ Opioid Users