ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project Narrative Chronic kidney disease (CKD) is present in nearly 20% of the mid-life U.S. population, and recent large cohort studies have raised the independent association of CKD with cancers of the urinary system. With elevated rates of cancer-specific mortality and common coexisting risk factors for renal or urothelial cancers (smoking, obesity, and hypertension), mid-life patients with CKD merit evaluation for cancer screening. We will build a simulation model for urinary system cancer screening, accounting for cancer-specific morbidity and mortality as well as competing mortality risks, and include stakeholder input on the acceptability of benefits and harms.

PI_NAMEs: KANG, STELLA  (contact)

PROGRAM_OFFICER_NAME: BURNETT, ANDREA NICOLE

PROJECT_TITLE: Tailored Screening for Urinary System Cancers in Patients with Chronic Kidney Disease

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: HOUSTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative Cerebral amyloid angiopathy (CAA), a common finding in over 90% of Alzheimer's disease (AD) cases, is characterized by the deposition of amyloid in the cerebrovascular compartment. This overlap between AD and vascular brain pathology in dementia has been difficult to separate, with AD and vascular dementia probably existing as a continuum of distinct but mechanistically related processes. The studies outlined in this proposal will allow us to dissect in detail the mechanisms by which CAA leads to cognitive decline and may identify novel therapeutic targets for CAA and AD.

PI_NAMEs: LASAGNA-REEVES, CRISTIAN  (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TITLE: CAA, Tau and Neurodegeneration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-H(55)]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: MADISON

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Our recently published work has identified a novel role in cellular secretion for type VII collagen, the largest of human collagen molecules, and our unpublished data have identified anti-viral compounds as potential drugs that can normalize disruption to secretion after loss of functional type VII collagen. Absent or non-functional type VII collagen leads to the devastating inherited disease recessive dystrophic epidermolysis bullosa characterized by skin and mucosa fragility, chronic wounds, progressive fibrosis and cancer. This project seeks to understand the secretory defects resulting from loss of functional type VII collagen and determine the mechanism of action for anti-viral drugs which we show can extend the lifespan of a murine model of recessive dystrophic epidermolysis bullosa.

PI_NAMEs: SOUTH, ANDREW  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TITLE: The role of collagen VII in extracellular matrix protein secretion

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: EGFR mutant NSCLC initially has a high response rate (70%) to EGFR tyrosine kinase inhibitors (TKIs), however, resistance to these drugs is inevitable. This project will use preclinical mouse models and human biospecimens to understand the role of the HGF-MET-TWIST1 pathway in mediating resistance to EGFR TKIs and if targeting TWIST1 can overcome or prevent resistance. Results of this proposal could lead to a new therapeutic paradigm for treatment of lung cancer through targeting EMT transcription factors.

PI_NAMEs: BURNS, TIMOTHY F. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TITLE: Targeting the HGF-MET-TWIST1 pathway to overcome EGFR TKI resistance

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


ADMINISTERING_IC: HS

ED_INST_TYPE: SCH OF BUSINESS/PUBLIC ADMIN

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

ORG_STATE: CA

PHR: In order to improve diagnostic quality, we need a systematic approach to measure it in large-scale data across clinical providers. In this project, we will develop such an approach and apply it to the specific setting of emergency department radiology, using data covering millions of visits and thousands of radiologists. Measures of diagnostic quality across a large number of clinicians in a wide range of locations will enable us to understand not only the determinants of diagnostic quality at the provider- and system-level but also its relationship with patient health outcomes.

PI_NAMEs: CHAN, DAVID CHIMIN (contact)

PROGRAM_OFFICER_NAME: HAUGSTETTER, MONIKA

PROJECT_TITLE: Measuring and Understanding Diagnostic Quality from Large-Scale Data

STUDY_SECTION: HSVR

STUDY_SECTION_NAME: Healthcare Systems and Values Research[HSVR]


ORG_CITY: KANSAS CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative We and others have demonstrated a causal role for an upregulated Claudin-1 expression in promoting colorectal cancer (CRC) metastasis. Here we propose to develop a novel inhibitor for preclinical testing and determine the specificity, efficacy and molecular mechanism for inhibiting CRC.

PI_NAMEs: DHAWAN, PUNITA  (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TITLE: Impact of CLDN1 inhibition on chemoresistance and metastasis of colon cancer

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: INDIANAPOLIS

ORG_DEPT: GENETICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Health Relevance Statement The goal of this research is to develop new statistical methods to study the mechanism of disease causing genetic variants by gene regulatory networks. Many diseases are caused by and/or associated with altered gene regulation. Results from this research will enable a more effective analysis of the gene regulatory mechanisms relevant to disease.

PI_NAMEs: DUREN, ZHANA  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TITLE: Statistical methods for interpretation of genetic variants by gene regulatory networks

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE The overall purpose of this national training program is to prepare doctoral nurses, including those with a Doctor of Nursing Practice (DNP) and/or a Philosophy Doctorate (PhD), to translate and integrate genetic and genomic content into doctoral nursing academic curricula, scholarship and practice. The foundations for this medical genomics educational training program include: Genomic Nursing Competency Implementation Strategic Plan 2014-20203, the Genomic Essential Genetic and Genomic Competencies for Nurses with Graduate Degrees4, and the Essentials of DNP Education5. The primary aims will be achieved through a half- day genomics course offered at an annual national doctoral nursing conference each January, followed by monthly webinars/web conferences through the remainder of the year to sustain interest, engage learners, and create a community of learners to become genomic nursing doctoral champions for their nursing school.

PI_NAMEs: CONNORS, LAURIE M (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TITLE: Translation and Integration of Genomics is Essential to Doctoral Nursing: "TIGER"

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: We proposed a novel therapeutic treatment for diabetic retinopathy, a leading cause of vision loss in working adults. Our strategy uses direct ocular delivery of a new class of drugs that activate nuclear receptors present in most cells of the retina called Retinoid X Receptor (RXR) agonists. We will test if RXR agonists can delay or reverse diabetes-induced retinal damage and investigate the mechanism of RXR-based therapy at cellular and molecular levels.

PI_NAMEs: GORBATYUK, MARINA  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TITLE: RXR-based therapy for diabetic retinopathy

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Amputation is a devastating but preventable complication of diabetes and peripheral arterial disease. Rural populations have multiple risk factors for amputation, however there is very little research about this issue in rural communities. This project will use community engagement approaches to develop and assess an amputation prevention intervention in a high-risk rural community in West Virginia that will be applicable to other high-risk rural areas in the country.

PI_NAMEs: MINC, SAMANTHA D (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TITLE: Implementing a Community-Engaged Amputation Prevention Intervention in Rural Patients with Diabetes and Peripheral Arterial Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: Project Narrative Worldwide and in the U.S. lung cancer is the leading cause of cancer mortality. Our proposal identifies risk factors at each step of lung cancer development to understand the mechanisms controlling and influencing its progression and to identify biomarkers that can be used clinically for early detection. We have also included diverse communities in our research program, in order to identify approaches to engage them in risk reduction strategies.

PI_NAMEs: AMOS, CHRISTOPHER I. (contact);HUNG, RAYJEAN J.;JOHANSSON, MATTIAS ALEXANDER;LIN, XIHONG

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TITLE: Integrative Analysis of Lung Cancer Etiology and Risk


PHR: Project Narrative Lung cancer is the leading cause of cancer death and results from interplay of environmental and genetic risk factors. This project seeks to use very large data sources to interrogate joint effects of environment and genetics that increase cancer risks for individuals to inform risk reduction and recruitment to and management of low dose spiral CT screening.

PI_NAMEs: AMOS, CHRISTOPHER I. (contact)

PROJECT_TITLE: Project 1: Smoking, environmental and genomic factors in lung cancer and managing risk


PHR: Project 2: Integrating Biomarkers into Lung Cancer Risk Profiling Narrative Many lung cancers occur in individuals who are not eligible for screening with low-dose computed tomography (LDCT). The INTEGRAL-AT Project 2 will improve LDCT screening eligibility criteria by incorporating biomarkers in risk assessment and evaluating the user acceptability in a community-based screening program. We will also identify novel biomarkers for lung cancer in never smokers.

PI_NAMEs: JOHANSSON, MATTIAS ALEXANDER (contact)


PHR: Project Narrative Lung cancer continues to be the most common cancer and the leading cause of cancer death worldwide, and the reduction of lung cancer death remains to be a global priority. While low- dose computed tomography (LDCT) can reduce lung cancer mortality by 20-30%, there are emerging challenges including how to optimize screening intervals, address issues of racial disparity, and possible overdiagnosis. To maximize the benefit-harm ratio, our project aims to optimize biomarker-informed screening pathway while focusing on under-represented populations such as African Americans and Asian never smokers.

PI_NAMEs: HUNG, RAYJEAN J. (contact)

PROJECT_TITLE: Translating Molecular and Clinical Data to Biomarker-Informed Screening Pathway


PHR: Project Narrative The administrative core ensures that data and processes needed to support all needs for the Integrative Analysis of Lung Cancer Risk and Etiology – Application and Translation program project are met. The administrative core also supports early stages of implementation science to translate findings from discovery science to communities at risk for lung cancer development.

PROJECT_TITLE: Administrative Core


ORG_CITY: Newark

ORG_DEPT: PEDIATRICS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Post-transplant lymphoproliferative disease (PTLD) is a group of rare malignant complications of solid organ transplant that include Hodgkin disease and non-Hodgkin lymphoma. About 50-80% are associated with Epstein-Barr virus (EBV) infection, yet the T cell and Natural Killer cell immune responses in primary EBV infection in children or during progression to PTLD are not well characterized. By performing detailed prospective immunological phenotyping through the first year after 278 pediatric organ transplants, we will unearth pathways that may inform EBV oncogenesis progression in immunocompromised populations.

PI_NAMEs: DHARNIDHARKA, VIKAS R. (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TITLE: Understanding the immune response changes to clinical interventions for Epstein-Barr virus infection prior to lymphoma development in children after organ transplants (UNEARTH)


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: STONY BROOK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project Narrative The accuracy of conventionally available R2*-MRI for liver iron quantification is negatively affected by patient motion and a high concentration of iron as commonly seen in patients with transfusion-induced iron overload. Accurate liver iron quantification is critical for managing iron overload and evaluating the efficacy of chelation treatment aimed at reducing body iron stores while minimizing adverse effects of chelator administration. This project will develop a rapid, motion-tolerant, and free-breathing abdominal R2*-MRI method, providing high- resolution volumetric liver R2* images for accurate iron quantification.

PI_NAMEs: KEE, YOUNGWOOK  (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TITLE: Rapid Free-Breathing 3D High-Resolution MRI for Volumetric Liver Iron Quantification

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: OMAHA

ORG_NAME: CREIGHTON UNIVERSITY

ORG_STATE: NE

PHR: Narrative During the critical search for drugs to treat COVID-19 patients, it’s important to select drugs with maximum antiviral efficacy and minimal side-effects. Using a combination of computer modeling and animal studies, we will test the potential for COVID-19 therapies to cause hearing loss; a side-effect of many drugs not often detected during clinical trials. Our goal is to help develop safer COVID-19 therapies.

PI_NAMEs: COFFIN, ALLISON B (contact)

PROGRAM_OFFICER_NAME: FREEMAN, NANCY

PROJECT_TITLE: Determining the ototoxic potential of COVID-19 therapeutics using machine learning and in vivo approaches

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICN-B(02)M]


ADMINISTERING_IC: CK

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE International travel may not only increase the risk of infection for an individual traveler, but may also contribute to the global spread of infections. This continuation application focuses on Global TravEpiNet -- a consortium of clinics providing pre-travel health advice, the driving force behind the Heading Home Healthy Program, and a platform for quantitative assessments of travel-related illnesses and interventions. GTEN’s mission is to advance the care of U.S. international travelers, with the goal of preserving and advancing the health of the American public.

PI_NAMEs: LAROCQUE, REGINA C (contact);RYAN, EDWARD T.

PROJECT_TITLE: CK21-001 - Global TravEpiNet (GTEN): U.S. Travelers' Health Research, Surveillance, Communication and Outreach Network Supplement - Pregnant Travelers


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: Project Narrative Anthracycline chemotherapeutic agents are commonly used in cancer treatment but can cause heart failure (HF), with older adults at increased risk. HF after anthracycline therapy has a poor prognosis and thus strategies to prevent anthracycline cardiotoxicity are needed. The proposed research will develop and externally validate a multivariable risk prediction model for HF in older adults with lymphoma, determine the utilization patterns of cardioprotective medications in routine clinical practice and elicit patient and provider preferences for cardioprotective strategies to support future clinical trials of cardioprotection in older adults with lymphoma.

PI_NAMEs: UPSHAW, JENICA  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TITLE: Prevention of Anthracycline Chemotherapy Cardiotoxicity

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE  Methylation of messenger RNAs (mRNAs) at the nitrogen-6 position of adenosine (m6A) has been suggested to enhance mRNA nuclear export through the interactions between m6A regulators and classical adaptor proteins of mRNA transport pathways. We have found that m6A methyltransferase METTL3 associates with the nuclear pore complex (NPC) via directly binding to a structural NPC component called NUP93, which assists in loading m6A-decorated mRNAs to the nuclear membrane and expedites their translocation through the NPC by the export receptor NXF1-NXT1. We aim to elaborate on each crucial step of this new mRNA transport axis and define the full repertoire of the target mRNAs. We will also investigate the basis of pathogenesis that stems from a defect in the METTL3-NUP93 interaction. As such, our proposed research will furnish novel insights into the function of the epitranscriptomic mark m6A in nuclear mRNA export and define its health relevance.

PI_NAMEs: XU, KEXIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TITLE: METTL3-NUP93 interaction facilitates the nuclear export of m6A-modified mRNAs

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative  Paid caregivers (e.g. personal care aides, home health aides, and other direct care workers) provide essential care that allows persons with dementia (PWD) to remain living at home, yet little is known about the lived experience of PWD receiving paid care. This project seeks to better understand factors that determine the roles that paid caregivers play in the home-based care of PWD. This will improve the care for PWD in the community by supporting the meaningful integration of paid caregivers in the person-centered dementia care team and guiding health policy to maximize the positive impact of paid caregivers on the lives of PWD.

PI_NAMEs: RECKREY, JENNIFER M (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TITLE: The Role of Paid Caregivers in Home-Based Dementia Care

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ORG_CITY: LA JOLLA

ORG_DEPT: NEUROSURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Common acquired or congenital airway abnormalities in children, such as subglottic stenosis (SGS) and tracheobronchomalacia, are typically assessed using semi-quantitative measures. Normative data can be used to establish quantitative measures of airway abnormality, but existing normative models do not fully assess airway geometry as they only consider airway cross-sectional area. This project will therefore develop a pediatric airway shape atlas to better capture 3D airway geometry and will explore its utility for predicting airway development and to assess airway abnormalities in children with subglottic stenosis.

PI_NAMEs: NIETHAMMER, MARC  (contact);ZDANSKI, CARLTON J

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TITLE: A Pediatric Atlas of Upper Airway Shape

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: 8. Public Health Relevance.  Interneuronal connection in the nervous system is essential for the proper function of the brain. Cognitive deficits in many psychiatric disorders arise from disruptions in neural connectivity, including disruptions within sensory circuits. The proposed study investigates the role of intercortical neuronal connections in in regulating sensory information processing and perceptual experience. Results from this study will reveal how brain function can deteriorate because of disruptions in the normal connection patterns among neurons. This information is important to provide deep understanding of normal and pathological function of the nervous systems.

PI_NAMEs: CLELAND, THOMAS A;LIN, YINGXI ;YU, CONGRONG RON (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TITLE: Circuit architecture and dynamics in odor representation and perception


ADMINISTERING_IC: HD

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PI_NAMEs: ETTENSOHN, CHARLES A.;HINMAN, VERONICA FRANCES (contact);VIZE, PETER D

PROJECT_TITLE: Administrative Core: An Integrated Multi PI and Multi Site Management Plan For Enhanced Echinobase


PROJECT_TITLE: Computational Support for All Echinobase Objectives


PROJECT_TITLE: Improved Annotation of Echinoderm Genomic Features


PROJECT_TITLE: Mining Information from Echinoderm Genomes and the Scientific Literature


PROJECT_TITLE: Dissemination: Communication, Training and Outreach in Support of Enhanced Echinobase


PROJECT_TITLE: Software Development to Enhance Echinobase


ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE  Prostate cancer patients on drugs that block testosterone action ultimately become resistant to therapy and follow a downhill course with poor outcomes. One mechanism of resistance is a process called lineage plasticity, in which cancerous cells acquire a new identity. In this proposal, we will use complementary biological and computational tools to determine how exactly cells become plastic and resistant to drugs.

PI_NAMEs: ZAIDI, SAMIR  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TITLE: Studies on Lineage Plasticity in Prostate Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: This proposed project promises to contribute significantly to the growing field of immuno-oncology by providing insights into a novel mechanism contributing to the development of immune-related adverse events (irAEs). In doing so, this work will lay the foundation for the development of a novel therapeutic strategy to suppress the side-effects associated with checkpoint inhibitor immunotherapies while also establishing previously unknown candidate biomarkers for predicting the development of these irAEs in cancer patients.

PI_NAMEs: HANKS, BRENT ALLEN (contact)

PROGRAM_OFFICER_NAME: PERLOFF, MARJORIE

PROJECT_TITLE: Role of the tumor NLRP3 inflammasome in the generation of anti-PD-1 antibody immunotherapy-associated toxicities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


PHR: This work will provide critical scientific insight into a novel adaptive resistance mechanism to anti-PD-1 antibody immunotherapy in cancer. These proposed studies are designed to characterize the NLRP3 inflammasome as a therapeutic target and biomarker capable of enhancing the efficacy of anti-PD-1 antibody immunotherapy. Therefore, this approach promises to provide a previously unrecognized immunotherapeutic target that will expand the cancer patient population responding to checkpoint inhibitor immunotherapy as well as a biomarker allowing for improved patient selection and more optimal tailoring of immunotherapy regimens to specific cancer patients.

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TITLE: Investigating the PD-L1:NLRP3 signaling axis as a tumor intrinsic mechanism of adaptive resistance to anti-PD-1 antibody immunotherapy


ORG_CITY: PITTSBURGH

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE Inherited retinal degeneration diseases like retinitis pigmentosa (RP) are caused by genetic defects leading to photoreceptor cell loss, irreversible loss of vision and eventual blindness. However, it is unclear how photoreceptors die or how to slow/stop/reverse this process. To better understand the disease mechanism and develop new therapies, we propose to: investigate whether the PARP dependent cell death pathway acts as a common RP mechanism; identify compounds which promote photoreceptor survival in new RP zebrafish model via perform in vivo phenotypic drug screening; and validate identified compounds in established mouse RP models.

PI_NAMEs: ZHANG, LIYUN  (contact)

PROGRAM_OFFICER_NAME: COOK, TIFFANY

PROJECT_TITLE: Drug Screening for Neuroprotectants in Novel Zebrafish Models of Retinitis Pigmentosa

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PI_NAMEs: COLLMAN, FORREST CHRISTIE;MACARICO DA COSTA, NUNO  (contact)


ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

PHR: PROJECT NARRATIVE Myosteatosis occurs when fat infiltrates skeletal muscle tissue. Myosteatosis is common and predicts cancer recurrence, cardiovascular disease, and death in colon cancer survivors. This study will determine if aerobic exercise improves prognosis in colon cancer survivors by reducing myosteatosis.

PI_NAMEs: BROWN, JUSTIN C (contact)

PROGRAM_OFFICER_NAME: BERRIGAN, DAVID

PROJECT_TITLE: Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colon Cancer

STUDY_SECTION: BMHO

STUDY_SECTION_NAME: Biobehavioral Medicine and Health Outcomes Study Section[BMHO]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE The common skin bacterium Staphylococcus epidermidis is important for maintaining a healthy skin microbiome but can also act as a deadly pathogen, and the difference in these outcomes may be determined by the immense genetic diversity that exists across the many different strains of this single bacterial species. However, the specific genes that contribute to pathogenic processes are still not understood, likely because over 25% of S. epidermidis genes have not been functionally characterized. I propose to overcome this gap in our understanding of S. epidermidis pathogenicity by developing computational tools that will analyze thousands of public datasets and link uncharacterized genes to functionally characterized genes based on correlations in gene expression, the requirement for genes in different growth conditions, and other phenotypic data.

PI_NAMEs: DOING, GEORGIA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TITLE: Transcriptomics compendia for the study of strain-level genetic diversity of the human skin microbiome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-A(20)L]


ORG_CITY: MINNEAPOLIS

ORG_NAME: FLYWHEEL EXCHANGE INC.

ORG_STATE: MN

PHR: Project Narrative Medical imaging is one of the key methods used by biomedical researchers to study human biology in health and disease. The imaging informatics platform described in this application will enable biomedical researchers to capture, analyze, and share imaging and related data. These capabilities address key bottlenecks in the pathway to discovering cures to complex diseases such as Alzheimer’s disease, cancer, and heart disease.

PI_NAMEs: MARCUS, DANIEL SCOTT (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TITLE: The XNAT Imaging Informatics Platform


ORG_CITY: NEW YORK

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PI_NAMEs: MORRISON, R. SEAN;SIU, ALBERT L (contact)


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Our research project is designed to improve the health and survival of children, adolescent, and adults living with HIV who suffer most from the world’s leading infectious causes of death: tuberculosis (TB) and HIV. Our team is uniquely positioned to develop, implement, and evaluate evidence-based, innovative approaches to prevent, find, and cure HIV-associated TB in five CDC target priority countries. Our research will develop innovative new strategies to improve our ability to FIND and PREVENT TB, while determining the most cost- effective prevention strategy and promoting best practices to SUSTAIN the impact of our work.

PI_NAMEs: MANDALAKAS, ANNA M (contact)

PROJECT_TITLE: Closing -TB GAPs - for people living with HIV: TB Guidance for Adaptable Patient-Centered Service


PHR: PROJECT NARRATIVE Patients with colon cancer who require chemotherapy dose reductions and treatment delays are twice as likely to experience disease recurrence and death. This study will determine the optimal dose of aerobic exercise that improves chemotherapy tolerability and is behaviorally feasible for colon cancer survivors.

PI_NAMEs: BROWN, JUSTIN C (contact);CAAN, BETTE J;MEYERHARDT, JEFFREY A

PROGRAM_OFFICER_NAME: TESAURO, GINA M

PROJECT_TITLE: Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon Cancer


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: MILWAUKEE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MARQUETTE UNIVERSITY

ORG_STATE: WI

PHR: This project investigates the perception of speech in the context of surrounding sounds for the normal auditory system, and the effects of background noise, hearing loss, and cochlear implant processing on speech perception. These context effects play a critically important in perception, allowing us to maintain stable perception despite considerable variability in sounds and in listening environments. An improved understanding of context effects should lead to improvements in hearing aids and cochlear implants, which will help individuals with hearing difficulties communicate more effectively.

PI_NAMEs: STILP, CHRISTIAN EDMUND (contact);WINN, MATTHEW BRANDON

PROGRAM_OFFICER_NAME: KING, KELLY ANNE

PROJECT_TITLE: Perception of speech in context by listeners with healthy and impaired hearing

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ORG_CITY: LIVERPOOL

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: TMLIVERPOOL SCHOOL OF TROPICAL MEDICINE

ORG_ZIPCODE: L3 5QA

PHR: PROJECT NARRATIVE This CoAg supports a collaboration between the Kenya Medical Research Institute (KEMRI), the US CDC and the Liverpool School of Tropical Medicine (LSTM) to support the Kenyan Ministry of Health to achieve major reductions in the malaria burden in areas with intense year-round transmission in western Kenya by 2025. The partnership will support the expansion of the malaria surveillance infrastructure to track the progress towards malaria transmission targets, evaluate different combinations of area-wide interventions targeting the malaria vector and asymptomatic parasite reservoir to reduce malaria transmission and strengthen case management. These activities will provide pivotal critical scientific knowledge to inform and guide malaria program implementation and reduce malaria-associated morbidity and mortality through the identification and scale-up and continued evaluation of evidence-based intervention strategies.

PI_NAMEs: TER KUILE, FEIKO OLAF (contact)

PROJECT_TITLE: Malaria Operations Research to Improve Malaria Control and Reduce Morbidity and Mortality in Western Kenya