NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Prevention;Women's Health Research

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Triple negative breast cancer is an aggressive disease; prevention and treatment have been hampered by its lower frequency and limited understanding of its biology. By integrating whole exome tumor mutation profiles with germline genetics, prospective risk factor data, pathology, and immune signature data this proposal addresses a number of important knowledge gaps—in particular, it will shed light on how genetic and nongenetic factors influence breast tumor molecular biology. Linking specific risk factors with triple negative tumor mutations will provide important mechanistic understanding in tumor evolution, which will open up avenues for prevention and treatment of triple negative breast cancers.

PI_NAMEs: TAMIMI, RULLA M (contact)

PROGRAM_OFFICER_NAME: CARRICK, DANIELLE M

PROJECT_TERMS: Address;Adjuvant Chemotherapy;African American Women;African ancestry;Area;Bioinformatics;Biology;Breast Cancer Epidemiology;Breast Cancer Patient;Breast Cancer Risk Factor;Cancer Prevention Study II;cancer subtypes;Categories;Cessation of life;Characteristics;Clinical;cohort;Data;Databases;Diagnostic;Disease;DNA;Epidemiology;epidemiology study;Etiology;European ancestry;Evolution;exome sequencing;experience;Frequencies;Gene Expression;Gene Expression Profile;Genes;Genetic;genetic epidemiology;Genetic Variation;genome wide association study;genome-wide;Genomics;Germ Lines;Immune;Immune response;Immunooncology;Immunotherapy;individualized medicine;interest;Joints;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Molecular;Molecular Biology;molecular subtypes;multidisciplinary;Mutate;Mutation;Neoadjuvant Therapy;non-genetic;Nurses' Health Study;Pathologic Mutagenesis;Pathology;Patients;phenotypic data;Play;Positioning Attribute;Prevention;Prevention strategy;Principal Investigator;Prognosis;prospective;Prospective, cohort study;Relapse;repository;Research;Resources;response;Risk;Risk Factors;Role;Sampling;Somatic Mutation;The Cancer Genome Atlas;Time;Tissues;treatment response;triple-negative invasive breast carcinoma;tumor;tumor exome;tumor progression;Woman;Work

PROJECT_TITLE: Prediagnostic exposures, germline genetics, and triple negative breast cancer mutational and immune profiles

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Hematology;Kidney Disease

ORG_CITY: COLUMBUS

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: RESEARCH INST NATIONWIDE CHILDREN'S HOSP

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research project is relevant to public health because nephrotic syndrome is a leading cause of end stage kidney disease in the United States. Current treatments for nephrotic syndrome are associated with severe side effects and are not always successful, so new approaches are urgently needed. Studying the mechanisms by which a blood clotting protein called thrombin injures specialized kidney cells called podocytes is expected to lead to discovery of new treatments for nephrotic syndrome and help prevent end stage kidney disease.

PI_NAMEs: KERLIN, BRYCE ANDREW (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Acute;Address;Animal Model;Anticoagulant therapy;Anticoagulants;Binding Proteins;Biology;Bioluminescence;Blood coagulation;Blood Coagulation Factor;Cause of Death;Cell Line;Chronic Kidney Failure;Coagulation Process;Complement;conditional knockout;Data;design;Development;Disease Outcome;Disease Progression;drug clearance;effective therapy;efficacy evaluation;End stage renal failure;Energy Transfer;Enzyme Precursors;Factor X;FDA approved;Flow Cytometry;Fluorescence;Functional disorder;Gene Modified;Generations;Genetic;Glomerular Filtration Rate;Goals;Half-Life;Health;Hematological Disease;improved;In Situ;inhibitor;Injury;innovation;Interruption;Kidney;kidney cell;knock-down;Knock-out;Knockout Mice;Mediating;Medical Research;Messenger RNA;Methods;Mission;Modeling;Molecular;Molecular Biology;Molecular Target;Mus;Mutagenesis;nanoparticle;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrotic Syndrome;new therapeutic target;novel;novel strategies;novel therapeutics;Oral;overexpression;Pathway interactions;Peptide Hydrolases;Persons;pharmacologic;Plasma;podocyte;Positioning Attribute;prevent;Proteinase-Activated Receptors;Proteins;Proteinuria;Prothrombin;Public Health;Publishing;Quality of life;Rattus;Reagent;Receptor Signaling;receptor-mediated signaling;Research;Research Priority;Research Project Grants;Role;side effect;Signal Induction;Signal Pathway;System;Techniques;Testing;Thrombin;Thromboplastin;United States;United States Food and Drug Administration

PROJECT_TITLE: Thrombin-Mediated Podocyte Injury Mechanisms

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Rehabilitation;Transplantation

ORG_CITY: MANCHESTER

ORG_NAME: PRO THERAPEUTICS LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE Rotator cuff (RC) tears are among the most common orthopedic injuries in the United States, resulting in more than 450,000 repairs are performed per year at a cost of more than $523M [1,46]. Current repair techniques focus on the development of biological or synthetic scaffold devices to reinforce the mechanical strength of the tendon- to-bone connection; however, these techniques do not promote enthesis regeneration, contributing to a failure rate of current RC repair procedures ranging from 20-95% [40-42,50,53]. STEL’s Engineered Tissue Graft for Rotator Cuff (ETG-RC) is an innovative approach to rotator cuff repair offering the possibility of a radical improvement in RC patient outcomes resulting from a fully biologic “off-the-shelf” tissue-engineered RC tendon graft that restores biomechanical properties of the tendon-humerus enthesis while providing an underlayment that allows the migration of endogenous cells, enhancing the regenerative capacity of the torn RC tendon.

PI_NAMEs: BOLLENBACH, THOMAS ;LARKIN, LISA M (contact);MEISELMAN, HANNAH

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Address;aging population;Allogenic;Animals;anterior cruciate ligament injury;Arthritis;Biological;biological development;biomaterial compatibility;Biomechanics;bone;bone marrow mesenchymal stem cell;Capital;cell bank;Cells;Characteristics;Cicatrix;Clinic;Clinical;Clinical Trials;Collagen;commercialization;Communities;cost;Data;design;Development;Devices;DNA;Engineering;fabrication;Failure;Fibrocartilages;first-in-human;Funding;Goals;healing;Histologic;Histology;Human;humerus;improved;in vivo;Injury;innovation;Investments;Laboratories;laboratory equipment;Life;manufacture;Marketing;mechanical signal;Mechanics;Methodology;Methods;Michigan;migration;mineralization;Modulus;Natural regeneration;novel;Operative Surgical Procedures;Orthopedics;Outcome;Patient-Focused Outcomes;Patients;Phase;Phase I Clinical Trials;Physiological;Procedures;Production;Property;protein structure;Protocols documentation;Qualifying;Recovery;Regenerative capacity;Regenerative Medicine;repair strategy;repaired;Research;Research Personnel;restoration;Risk;Rotator Cuff;rotator cuff injury;rotator cuff tear;safety testing;scaffold;Sheep;Site;skeletal tissue;Small Business Innovation Research Grant;soft tissue;Source;standard of care;Sterility;success;surgery outcome;Surgical sutures;Suture Techniques;Techniques;Technology;tendon graft;Tendon Injuries;Tendon structure;Testing;Tissue Engineering;Tissue Grafts;tissue regeneration;Tissues;Toxicology;Translations;United States;Vision;Woman;Work

PROJECT_TITLE: Development of a Novel Engineered Tendon Graft to Assist in Repair of Rotator Cuff Injuries


ED_INST_TYPE: SCHOOLS OF MEDICINE

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: NARRATIVE This research project is relevant to public health because it dissects a neuronal connection between the gut and the brain that acts as a sensor for ingested sugar. This knowledge will serve to develop therapies for metabolic diseases that affects over 48% of U.S. adults.

PI_NAMEs: BOHORQUEZ, DIEGO V (contact)

PROGRAM_OFFICER_NAME: MARUVADA, PADMA

PROJECT_TERMS: Adult;Affect;Animals;Behavior;Behavioral;behavioral phenotyping;body sense;Brain;Calcium;Cells;Cholecystokinin;Colon;Communication;Consumption;Cues;Data;design;Desire for food;Detection;detection of nutrient;Duodenum;Electrophysiology (science);Endocrine;Enteroendocrine Cell;Epithelial Cells;Epithelium;Event;experimental study;Fiber Optics;flexibility;Foundations;gastrointestinal epithelium;glutamatergic signaling;Glutamates;Goals;Hormone secretion;Hormones;Hour;Human;Image;Ingestion;Intake;intestinal epithelium;Intestines;Knowledge;Label;Link;Mediating;Metabolic Diseases;Metabolic syndrome;millisecond;Modality;Mucous Membrane;Mus;Nerve;neural circuit;Neuroepithelial Cells;Neurons;Neurophysiology - biologic function;neurotransmission;neurotransmitter release;Neurotransmitters;Nutrient;optogenetics;Oral cavity;Outcome;Outcomes Research;paracrine;Peptides;Pharmacology;Pharmacotherapy;Population;preference;promoter;Property;Public Health;receptor;Research Project Grants;Resolution;response;Rewards;Role;sensor;Sensory;Signal Pathway;Signal Transduction;Signaling Molecule;SLC2A1 gene;Small Intestines;Sodium;Specificity;Stimulus;Sucrose;sugar;sweet taste perception;Sweetening Agents;Synapses;System;Taste Perception;Testing;Therapeutic;therapy development;Time;Transcript;Transducers;two-photon;Vagus nerve structure;vesicular glutamate transporter 1

PROJECT_TITLE: Glutamatergic neurotransmission in gut neuropod cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Narrative Immune checkpoint inhibitors (ICI) produce durable responses in many cancer patients, but may cause cardiac, vascular, and other organ inflammation leading to morbidity and mortality. We propose to determine the role of ICI in mitigating cardiovascular injury using genetic and pharmacologically treated mouse models, and perform intensive cardiac monitoring in a large cohort of long-term survivors treated with ICI. This study will provide significant insights into the long-term complications of these therapies and enable targeted screening and prevention strategies for patients at risk.

PI_NAMEs: JOHNSON, DOUGLAS B;MOSLEHI, JAVID J (contact)

PROGRAM_OFFICER_NAME: DESVIGNE-NICKENS, PATRICE

PROJECT_TERMS: Acute;Address;Affect;anti-PD-1;Arrhythmia;Atherosclerosis;Autopsy;Blood Pressure;Blood Vessels;Body Composition;C-reactive protein;cancer immunotherapy;Cancer Patient;Cancer Survivor;cancer therapy;cancer type;Cardiac;cardiac magnetic resonance imaging;Cardiopulmonary;Cardiotoxicity;Cardiovascular Diseases;cardiovascular effects;cardiovascular health;cardiovascular injury;Cardiovascular Pathology;Cardiovascular system;Cells;checkpoint therapy;Chronic;Clinical;clinical phenotype;cohort;Collection;coronary artery calcification;CTLA4 gene;Data;Death Rate;Development;Echocardiography;Fasting;Fibrosis;General Population;Genetic;Glucose;Health;heart damage;Heart Injuries;Immune;immune activation;immune cell infiltrate;Immune checkpoint inhibitor;immune self tolerance;Immunooncology;improved;Infiltration;Inflammation;Inflammatory;inhibitor;insight;International;Ischemia;ischemic injury;Knock-out;Ligands;Lipids;Literature;Long-Term Effects;Long-Term Survivors;Longitudinal cohort;Longitudinal Studies;Malignant Neoplasms;Mediating;Metabolic;Modeling;Molecular;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;multidisciplinary;Muscle Cells;Myocardial;Myocardial dysfunction;myocardial injury;Myocardial Ischemia;Myocarditis;Oncology;Organ;Pathologic;Pathologic Processes;patient subsets;Patients;PD-L1 blockade;Pericarditis;pharmacologic;Phenotype;Physiological;Population;pre-clinical;Pre-Clinical Model;prevent;Prevention strategy;programmed cell death ligand 1;programmed cell death protein 1;programs;Prospective cohort;Recovery;Regimen;Residual state;Resources;response;Retrospective cohort;Risk;Risk Factors;Role;screening;Severity of illness;side effect;Signal Transduction;Smoking;stressor;success;synergism;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;Time;Toxic effect;treatment strategy;Troponin;Vascular Endothelial Growth Factors;vascular injury;Vasculitis;Ventricular Remodeling;Weight

PROJECT_TITLE: Long-Term Cardiovascular Sequelae of Cancer Immunotherapies

STUDY_SECTION: CICS

STUDY_SECTION_NAME: Clinical and Integrative Cardiovascular Sciences Study Section[CICS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Hypertension;Neurodegenerative;Neurosciences;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative The pathways linking individual differences in midlife cardiovascular stress physiology to risk for cerebrovascular disease and vascular determinants of later life dementias are uncertain. From a public health perspective, it is important to specify these pathways to (1) understand plausible mechanistic factors by which stress relates to cerebrovascular risk and (2) identify factors that could be objectively identified and possibly targeted for modification in otherwise healthy midlife adults at risk for future dementia.

PI_NAMEs: GIANAROS, PETER J (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Accounting;Acute;Adult;aged;Alzheimer's Disease;arterial stiffness;Baroreflex;Behavioral;Biological;Biological Testing;Blood flow;Blood Pressure;Blood Vessels;Brain;Brain imaging;Cardiac Output;Cardiovascular Diseases;cardiovascular health;Cardiovascular Physiology;cardiovascular risk factor;Cardiovascular system;cerebrovascular;Cerebrovascular Disorders;cerebrovascular health;Cerebrum;Clinical;cohort;Communities;Coronary heart disease;Data;Dementia;dementia risk;Disease Marker;endothelial dysfunction;Endothelium;Equation;Exhibits;Failure;Future;Goals;hemodynamics;Hippocampus;Hypertension;Impaired cognition;Impairment;Individual;Individual Differences;Ischemic Stroke;Knowledge;late life;Lesion;Link;Liquid substance;male;Measures;medial temporal lobe;Mediating;Mediation;Mediator;middle age;Modeling;National Heart, Lung, and Blood Institute;neurovascular injury;Outcome;Pathway interactions;Penetration;Peripheral;Peripheral Resistance;Persons;Phenotype;Physiologic pulse;Physiology;pre-clinical;pressure;Prevention;Protocols documentation;psychological stressor;Public Health;Reaction;reactive hyperemia;Reproducibility;Research;Risk;risk stratification;Robin bird;Role;Sampling;Severities;sex;sex as a biological variable;Site-Directed Mutagenesis;social;Source;Specific qualifier value;stem;Strategic vision;Stress;stress reactivity;stressor;Testing;Tissues;transmission process;Vascular Cognitive Impairment;Vascular Dementia;Vascular Diseases;Vascular remodeling;Visit;Visual;volunteer;white matter;Woman

PROJECT_TITLE: Midlife cardiovascular stress physiology and preclinical cerebrovascular disease

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Palliative Care;Social Determinants of Health

ORG_CITY: MBARARA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY

PHR: NARRATIVE The World Health Organization developed the dementia toolkit for community workers, consisting of evidence-based practices for early detection and management of dementia and caregiver support. However, the toolkit has not been adopted because there is lack of an appropriate and effective implementation strategy. We propose to develop and evaluate the feasibility of a culturally tailored implementation strategy consisting of the WHO dementia toolkit by indigenous village-based LHWs to provide dementia care at village level.

PI_NAMEs: WAKIDA, EDITH  (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Address;Adopted;Adoption;Adult;Adverse event;Africa South of the Sahara;Age;Attitude;Awareness;care delivery;Caregiver Burden;Caregiver support;Caregivers;Caring;Communities;community empowerment;Community Workers;Country;Data;Decentralization;Dementia;dementia care;Dementia caregivers;design;Detection;Early Diagnosis;effectiveness/implementation study;Emotional;Enrollment;Evaluation;evidence base;Evidence based practice;experience;Family Caregiver;Feasibility Studies;Financial Hardship;Focus Groups;Friends;Future;Goals;Health;health care delivery;Health Personnel;health plan;Health Services;Health system;Healthcare;Healthcare Systems;Home;Household;Human Resources;implementation design;implementation intervention;implementation outcomes;implementation strategy;improved;Indigenous;indigenous community;Injury;innovation;Intervention;Interview;Knowledge;Left;low and middle-income countries;Measures;member;Modeling;older adult;Outcome;Patients;Perception;Persons;Pilot Projects;pilot test;Population;preference;Prevalence;Primary Health Care;primary outcome;process improvement;Proctor framework;Promoting Action on Research Implementation in Health Services framework;prototype;Provider;Public Health;Public Health Education;Recommendation;Research;Resource-limited setting;response;Role;Rural;rural area;rural setting;Services;Site;social;Structure;Supervision;Testing;tool;Training;Uganda;United States;virtual;Voting;Withdrawal;Work;working group;World Health Organization

PROJECT_TITLE: Pilot feasibility study of the WHO Lay Health Worker Dementia Care, with Internal Facilitation (WLDC+IF) in rural Uganda

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Fibromyalgia;Neurosciences;Pain Research

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Fibromyalgia is a chronic debilitating pain condition that affects about four million people in the U.S. alone. The objective of this project is to establish and validate a clinically relevant animal model of fibromyalgia. This new model will provide a useful preclinical platform to evaluate novel therapeutics for fibromyalgia treatment and to conduct in-depth mechanistic investigations of fibromyalgia pathogenesis.

PI_NAMEs: MAO, JIANREN  (contact)

PROGRAM_OFFICER_NAME: CONRAD, CHRISTOPHER GARNER

PROJECT_TERMS: adeno-associated viral vector;Adult;Affect;Age;Alkaline Phosphatase;animal facility;Animal Model;Animals;Anxiety;anxiety-like behavior;Behavior;behavior test;Behavioral;behavioral phenotyping;Biochemical;Biological Assay;Biological Markers;Blinded;Brain;Brush Border;Cerebrospinal Fluid;Characteristics;Chronic;chronic widespread pain;Clinical;clinical diagnostics;Clinical Research;clinically relevant;Cognitive;cognitive function;cohort;cold stress;cytokine;debilitating pain;density;diagnostic biomarker;duloxetine;Environment;Enzymes;Epidemiology;Etiology;Exhibits;Face;Fatigue;FDA approved;Female;Fibromyalgia;fibromyalgia patients;Functional disorder;Genetic;Genotype;gut homeostasis;Heterogeneity;Histologic;Housing;Hypersensitivity;Immune;improved;Injections;innovation;Intestinal permeability;Intestines;Intramuscular;Investigation;Knock-out;Knockout Mice;male;Measurement;Measures;Mechanics;Mental Depression;Meta-Analysis;Modeling;Molecular;mouse model;Mus;Muscle;Nerve Fibers;neuroinflammation;Neurologic;Neurotransmitters;novel;novel therapeutics;Opioid;Outcome Measure;pain behavior;Pain Research;Pathogenesis;Persons;Pharmaceutical Preparations;Phase;Phenotype;Phenylalanine;phosphatase inhibitor;pre-clinical;pre-clinical research;pregabalin;primary outcome;Procedures;Protocols documentation;Publishing;Reporter;Reproducibility;Research;Research Personnel;Reserpine;Role;Saline;Serum;sex;Skeletal Muscle;Sleep disturbances;sound;spontaneous pain;Standardization;stool sample;Stress;subcutaneous;Substance P;Supplementation;Symptoms;systemic inflammatory response;Technology;Testing;Therapeutic;tool;Validation

PROJECT_TITLE: Establishment and Validation of a Novel Animal Model of Fibromyalgia

STUDY_SECTION: NSD

STUDY_SECTION_NAME: Neurological Sciences and Disorders A Study Section[NSD-A]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: SMITHFIELD

ORG_NAME: BRYANT UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE: Alcohol Use Disorder (AUD) is a debilitating disorder, which manifests as problematic patterns of alcohol use and cravings in the face of abstinence. Here we use the fruit fly to understand how alcohol co-opts neural circuits to drive maladaptive drug seeking behaviors. Understanding how these circuits change in the context of alcohol is critical for the development of more specific and effective circuit-based AUD treatment strategies.

PI_NAMEs: SCAPLEN, KRISTIN MARIE (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Abstinence;addiction;Address;Alcohol consumption;alcohol craving;Alcohol dependence;alcohol effect;alcohol exposure;alcohol memory;alcohol reward;alcohol use disorder;Alcoholic Intoxication;Alcohols;Animals;Arousal;Aversive Stimulus;Behavior;Behavioral;Biosensor;Brain;calcium indicator;Central Nervous System;Chronic;Complex;craving;Cues;Data;depressive symptoms;Development;Disease;Dissection;Dopamine;dopaminergic neuron;Drosophila genus;Drosophila melanogaster;drug seeking behavior;economic cost;effective therapy;Environment;Equilibrium;Exhibits;experience;experimental study;extracellular;flexibility;fly;Genetic;Genetic Epistasis;Goals;Grant;Heterogeneity;improved;in vivo calcium imaging;Individual;insight;Institution;Intervention;Learning;maladaptive behavior;Mammals;Maps;Measures;Memory;memory acquisition;memory encoding;memory process;memory retrieval;model organism;Mushroom Bodies;neural;neural circuit;neurogenetics;Neurons;Odors;optogenetics;Outcome;Output;Pattern;Play;Population;preference;Public Health;Recovery;recruit;Relapse;relapse risk;Research;Resistance;Resolution;response;Retrieval;Rewards;Role;Sedation procedure;Shapes;Specificity;Structure;Students;Sucrose;temporal measurement;Testing;tool;Training;treatment strategy;two photon microscopy;undergraduate student;Universities;Update;Visualization;Work

PROJECT_TITLE: Neural Circuitry Mechanisms Underlying Maladaptive Reward Memories in Drosophila

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Brain Disorders;Clinical Research;Disability Research;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

PHR: Project Narrative Our proposal aims to detect neurodegenerative changes in the multiple sclerosis (MS) spinal cord prior to axonal loss and irreversible neurological disability using the best available imaging modalities with 7 Tesla (T) MRI. The premise for our hypothesis that T2* intermediate lesions detect ongoing neurodegenerative processes are based on our MRI-pathology studies. Results from our proposal will inform the applicability of our methods to clinical 3T MRI and the feasibility of determining the role of spinal cord lesion subtypes with clinical disability and axonal loss (atrophy).

PI_NAMEs: MAHAJAN, KEDAR  (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: 3-Dimensional;Acceleration;Address;Age;Atrophic;Autopsy;Axon;Brain;Brain imaging;Cervical;Cervical spinal cord structure;Cervical spine;Characteristics;Classification;Clinical;clinical practice;cohort;Corticospinal Tracts;Data;Data Set;Demyelinations;Detection;Diagnosis;disability;Disease;Disease Surveillance;Distal;experience;feasibility testing;Functional impairment;Future;imaging biomarker;imaging modality;improved;in vivo;Inflammatory;Injury;Investigation;Lateral;Lead;Lesion;Lifelong disability;Macrophage;Magnetic Resonance Imaging;Measures;Methods;Microglia;Monitor;Motor;Multicenter Studies;Multiple Sclerosis;multiple sclerosis patient;Myelin;Nerve Degeneration;Neural Pathways;Neurological disability;novel strategies;Pathology;Patients;Pattern;Phagocytes;Play;Positioning Attribute;prevent;Process;Progressive Disease;prospective;Race;Reporting;Role;Sensitivity and Specificity;Sensory;sex;spatial relationship;Spinal Cord;spinal cord imaging;Spinal Cord Lesions;Swelling;Therapeutic Intervention;Thinness;Tissues;Treatment Efficacy;Vertebral column;Wallerian Degeneration;white matter;Work

PROJECT_TITLE: Investigation of discrete neurodegenerative changes of the in vivo multiple sclerosis spinal cord using 7T MRI

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The continued development of effective and specific disease treatments is essential for addressing unmet and emerging threats to human health. This project will transform the development of emerging therapeutics based on RNAs. The project directly supports the mission of the NIH by furthering our understanding of the function of exomeres, recently identified extracellular nanoparticles, and informing the development of novel RNA-based therapeutics.

PI_NAMEs: WALTON, STEPHEN PATRICK (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Address;Amphiregulin;Antisense Oligonucleotides;Binding;Biogenesis;bioprocess;Biotechnology;Categories;Cell Culture Techniques;cell type;Cells;Centrifugation;Charge;clinical application;Clustered Regularly Interspaced Short Palindromic Repeats;Complement;Complex;cost effective;delivery vehicle;Development;Disease;Encapsulated;Endocytosis;Endosomes;Epidermal Growth Factor Receptor;extracellular;extracellular vesicles;Field Flow Fractionation;Filtration;Formulation;Foundations;Future;Goals;Health;Human;human disease;improved;industrial production;innovation;intercellular communication;Laboratories;Ligands;lipid nanoparticle;Location;Mediating;Membrane Lipids;Messenger RNA;Methods;microRNA delivery;MicroRNAs;Mission;Molecular;nanoparticle;novel;novel strategies;nucleic acid delivery;nucleic acid-based therapeutics;Nucleic Acids;particle;physical property;prevent;Process;Production;Property;Proteins;Protocols documentation;Publishing;receptor mediated endocytosis;Repression;Reproducibility;RNA;RNA delivery;RNA Interference;RNA Interference Pathway;Role;scale up;Shapes;siRNA delivery;Small Interfering RNA;success;targeted delivery;Technology;Therapeutic;therapeutic RNA;therapeutically effective;Tissues;trafficking;United States National Institutes of Health;uptake;Work

PROJECT_TITLE: Novel, Scalable Approach for Isolation of Exomeres for RNA Delivery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-X (81)]


NIH_SPENDING_CATS: Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative PACS2 E209K pathogenic substitution is solely responsible for patients presenting with PACS2 Syndrome, yet the mechanisms that lead to the neurodevelopmental defects remain largely unknown. In this proposal, we will use modern molecular biology and stem cell techniques combined with neuroscience tools to identify functional consequences resulting in alterations in neural differentiation and excitability. Understanding at a cellular and molecular level the basis for how the PACS2 E209K substitution affects the developing nervous system, may lay the foundation for novel therapeutic approaches.

PI_NAMEs: GUEMEZ GAMBOA, ALICIA DIONE (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Address;Affect;Apoptosis;Apoptotic;BIM Bcl-2-binding protein;Binding;Caspase;Cathepsins B;Cell Death;Cell Line;Cell membrane;Cell Membrane Permeability;Cell Physiology;Cells;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Craniofacial Abnormalities;CRISPR/Cas technology;Cycloheximide;Cytosol;Defect;Disease;disease-causing mutation;effective therapy;Epilepsy;Etiology;excitatory neuron;Family;Foundations;Funding;Generations;Genes;Genetic study;Genetic Variation;Glutamates;Golgi Apparatus;Half-Life;Immunofluorescence Immunologic;Impaired cognition;Impairment;Individual;Induced Neurons;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Induction of Apoptosis;insight;Intellectual functioning disability;Knock-in;Lysine;Lysosomes;Mediating;Mitochondria;mitochondrial membrane;model organism;Modeling;Modernization;Molecular;Molecular Biology;multi-electrode arrays;multicatalytic endopeptidase complex;Muscle hypotonia;Nervous System;neural;Neurobiology;Neurodevelopmental Disorder;Neurologic;neuron loss;Neurons;Neurosciences;novel therapeutic intervention;overexpression;PACS1 Syndrome;paralogous gene;Pathogenicity;Pathway interactions;patient derived induced pluripotent stem cells;patient responsibilities;Patients;Pattern;Physiologic pulse;Predisposition;pro-apoptotic protein;Protein Sortings;protein transport;Proteins;recruit;Recurrence;Reporting;Research;risk variant;Seizures;Signal Transduction;Staurosporine;stem cell model;stem cells;Stimulus;Stress;Synapses;Syndrome;System;targeted treatment;Techniques;Testing;TNFSF10 gene;tool;trafficking;translational genetics;Ubiquitination;Variant;Work

PROJECT_TITLE: Pathogenic mechanisms of PACS2 syndrome variant in developing neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: NARRATIVE We propose the first histologically-validated and detailed anatomical study using ultra-high resolution MRI of the human cerebellar cortex. The human cerebellar cortex contains the majority of neurons in the central nervous system and is increasingly recognized as being affected in a range of neurological disorders, but there is little detailed knowledge about its anatomical organization, particularly the architecture of the molecular layer. Results will elucidate the three-dimensional anatomical organization of the human cerebellar cortex and relate it to MRI based measures to produce validated methodologies that can be employed translationally to detect structural alterations in clinical populations.

PI_NAMEs: MAKRIS, NIKOLAOS ;RUSHMORE, RICHARD JARRETT (contact)

PROGRAM_OFFICER_NAME: LEE, CRYSTAL ANNE

PROJECT_TERMS: 3-Dimensional;Affect;Alzheimer's Disease;Anatomy;Animal Model;Applications Grants;Architecture;autism spectrum disorder;Axon;bench to bedside;Brain region;Brain Stem;Cells;Central Nervous System;Cerebellar Cortex;Cerebellum;Characteristics;Clinical;Complex;connectome;Data;Data Set;Dendrites;Diagnostic;Diffusion Magnetic Resonance Imaging;Disease;Down's Syndrome;Felis catus;Fiber;Fragile X Syndrome;Goals;Grant;granule cell;Heterogeneity;Histologic;Histological Techniques;Histology;Human;Image;Immunohistochemistry;Knowledge;Label;Laboratories;Magnetic Resonance Imaging;Measures;Medicine;Methodology;Methods;Modeling;Molecular;Monitor;MRI Scans;multimodality;Nervous System Disorder;neuroimaging;Neurons;Neurosciences;Pathology;Pattern;Population;Process;Purkinje Cells;Research;Resolution;Rodent;Sampling;Schizophrenia;Spinocerebellar Ataxias;Structural defect;Structure;Syndrome;Techniques;Testing;Thinness;three dimensional structure;Three-dimensional analysis;Tissue Sample;Tissues;tractography;Translating;two-photon;ultra high resolution;Visualization;white matter;Work

PROJECT_TITLE: Elucidating the three-dimensional organization of the human cerebellar cortex using histological and ultra-high resolution structural MRI approaches

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE The proposed research is relevant to public health because of the critical need for more effective treatments for osteoarthritis (OA), which is a common disease with a large societal impact. This work focuses on the specific single nucleotide variants that are responsible for genetic risk in OA. Increased understanding of the causes of OA will support the development of novel interventions to prevent, slow, and treat this debilitating disease of the joint.

PI_NAMEs: DIEKMAN, BRIAN O (contact)

PROGRAM_OFFICER_NAME: ZHENG, XINCHENG

PROJECT_TERMS: Age;Alleles;arthropathies;ATAC-seq;Binding;Binding Sites;Bioinformatics;Biological Assay;Cadaver;Cartilage;cartilage degradation;Cartilage Matrix;causal variant;cell type;Cells;Chondrocytes;Chromatin;Chromatin Loop;Chronic Disease;Cleavage Under Targets and Release Using Nuclease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Conditioned Reflex;Coupling;Data;Degenerative polyarthritis;Development;disability;Disease;Disease Progression;disorder risk;DNA;Early Intervention;effective therapy;Enhancers;Environment;Epigenetic Process;expectation;Femur;Fibronectins;follow-up;functional genomics;Gene Deletion;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Risk;genetic risk factor;genetic variant;Genome;genome wide association study;genomic data;Genomics;Goals;Heritability;high throughput analysis;Histones;Homeostasis;Human;innovation;insight;Intervention;joint injury;Joints;Libraries;Mediating;Molecular Target;novel;Oligonucleotides;Outcome;Pathology;Pathway Analysis;Phenotype;prevent;promoter;protective allele;Public Health;Quantitative Trait Loci;Recording of previous events;Regulation;Replacement Arthroplasty;Reporter;Reporter Genes;Reproducibility;Research;response;Response to stimulus physiology;Risk;risk variant;Single Nucleotide Polymorphism;Stimulus;Testing;Therapeutic;Thinking;Tissue Donors;Transcript;transcription factor;transcriptome sequencing;Transfection;Twin Studies;United States National Institutes of Health;Untranslated RNA;Validation;Variant;Work

PROJECT_TITLE: Functional interrogation of putative osteoarthritis causal variants

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Back Pain;Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Dissemination and Implementation Research;Emergency Care;Health Services;Opioids;Pain Research;Physical Rehabilitation;Rehabilitation

ORG_DEPT: EMERGENCY MEDICINE

PHR: PROJECT NARRATIVE Low back pain affects almost half of all Americans per year and is the most common reason for which opioids are prescribed. Multiple randomized controlled trials have demonstrated that early referral to physical therapy in the outpatient setting is efficacious for low back pain, but it is unknown whether these same benefits can be extended to patients evaluated by physical therapists in emergency department settings. This multi-site feasibility trial will test the feasibility and fidelity of an “embedded” emergency department physical therapy intervention for low back pain in preparation for a future full-scale multi-site trial.

PI_NAMEs: CIOLINO, JODY D.;KIM, HOWARD S (contact);YOUNGQUIST, SCOTT TRAVIS

PROGRAM_OFFICER_NAME: MURRAY, PETER DANIEL

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Affect;alternative treatment;Ambulatory Care Facilities;American;Back Pain;Behavior Therapy;Behavioral Medicine;Biophysics;biopsychosocial;Caring;Chicago;chronic pain;Cities;Clinic;Clinical effectiveness;Clinical Trials;Collection;Data;Dedications;Development;Diagnosis;Early Intervention;effectiveness outcome;efficacy evaluation;Electronic Health Record;Emergency Care;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency Situation;Environment;Evaluation Reports;experience;feasibility testing;feasibility trial;follow-up;Foundations;Fright;Functional impairment;Funding Opportunities;Future;General Population;General Practitioners;Health;health care service utilization;Health system;Healthcare Systems;Hospitals;Human Resources;hybrid type 1 trial;Hybrids;Illinois;Immobilization;implementation barriers;implementation/effectiveness;improved;Injury;Inpatients;interest;Intervention;Low Back Pain;Methods;metropolitan;mind/body;Modeling;motivational enhancement therapy;multi-site trial;multidisciplinary;National Center for Complementary and Integrative Health;Natural History;Opioid;opioid use;Outcome;Outpatients;Pain;pain catastrophizing;pain model;pain reduction;pain symptom;Patient Outcomes Assessments;Patients;Pharmaceutical Preparations;physical model;physical therapist;Physical therapy;Pilot Projects;pilot test;Population;Preparation;prescription opioid;Primary Care Physician;Process;programs;prospective;Protocols documentation;Psychology;psychosocial;psychosocial stressors;Public Health;randomized trial;randomized, clinical trials;Randomized, Controlled Trials;Rehabilitation therapy;Reporting;Research;Research Personnel;Research Priority;Role;Severities;Site;Sodium Chloride;Specialist;standard care;success;Testing;Therapeutic Intervention;Time;Training;treatment as usual;Treatment Protocols;treatment strategy;Utah;Visit;Vulnerable Populations;Work

PROJECT_TITLE: A Multi-Site Feasibility Trial of Embedded Emergency Department Physical Therapy for Back Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Optic nerve injuries often lead to the degeneration of retinal ganglion cells causing irreversible blindness. While the late stages of degeneration, in which retinal cells die, are well studied, much less is known about the earliest signs of retinal dysfunction following these injuries. We are developing a new preparation of the intact, perfused mouse eye where, for the first time, we will be able to make chronic recordings of retinal ganglion cells for hours to days after optic nerve cut and map the earliest changes in their light responses.

PI_NAMEs: SCHWARTZ, GREGORY WILLIAM (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Animals;Area;Axotomy;Bathing;Blindness;Blood Circulation;Blood flow;Calcium;Cell Death;Cell Physiology;Cell Survival;cell type;Cells;Central Nervous System;Cessation of life;Chronic;Classification;Databases;density;Diagnosis;Diagnostic;Disease;Disease Progression;Electrodes;experimental study;Eye;Fluorescence;Foundations;Functional disorder;Future;Gene Expression;Hour;Image;imaging approach;improved;in vivo;Individual;individual response;Injury;Knowledge;Light;Light Cell;Location;Maps;Measurement;Measures;Methods;Modeling;Molecular;Morphology;mouse model;Mus;Nerve;nerve damage;neural;Optic Nerve;Optic Nerve Injuries;optic nerve regeneration;Optic Nerve Transections;Outcome Measure;Pathway interactions;Pattern;Perfusion;pharmacologic;Photoreceptors;Physiological;Preparation;Publishing;Reporting;Research;response;Retina;retinal axon;Retinal Diseases;retinal ganglion cell degeneration;Retinal Ganglion Cells;Retrograde Degeneration;selective expression;sensor;sight restoration;Specificity;Stimulus;Synaptic Transmission;Testing;Time;Transgenic Animals;Transgenic Organisms;transmission process;two-photon;Typology;Work

PROJECT_TITLE: Measuring retinal ganglion cell spike responses in the intact perfused eye following optic nerve injury

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 1 Study Section[PED1]


ORG_CITY: OKLAHOMA CITY

ORG_NAME: OKLAHOMA MEDICAL RESEARCH FOUNDATION

ORG_STATE: OK

PHR: Project Narrative The loss of skeletal muscle mass can occur through genetic or external factors such as disease, hospitalization, or aging, and affect the quality of life for many people. In my proposal, I address this problem by studying an important protein (Ubiquitin Protein Ligase E3 Component N-Recognin 5) to determine its role in the development of skeletal muscle atrophy and growth. Findings from my proposal have great potential to improve the lives of people impacted by muscle wasting and may provide a basis for new therapeutic strategies to be identified.

PI_NAMEs: HUGHES, DAVID C (contact)

PROGRAM_OFFICER_NAME: LINDHURST, MARJORIE JEAN

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Aging;Atrophic;Chronic;Chronic Disease;Complex;Crush Injury;Data;Disease;Electroporation;Exercise;Experimental Models;Exposure to;Family member;Fasting;Female;Gastrocnemius Muscle;Genetic;genetic manipulation;Growth;Health;Hindlimb;Homeostasis;Hospitalization;Human Genome;human model;Hypertrophy;Impairment;improved;in vivo;Individual;inhibitor;knock-down;Maintenance;male;Mediating;Modeling;Molecular;mTOR Inhibitor;multicatalytic endopeptidase complex;Mus;Muscle;muscle form;Muscular Atrophy;Myopathy;Nerve Crush;novel;novel therapeutic intervention;overexpression;Pathway interactions;Persons;Pharmaceutical Preparations;Phase;Pilot Projects;Plasmids;Positioning Attribute;Process;protein activation;Protein Biosynthesis;protein degradation;Proteins;Quality of life;recognins;Recovery;Regulation;Research;RNA Interference;Rodent Model;Role;Signal Transduction;Sirolimus;Skeletal Development;Skeletal Muscle;skeletal muscle wasting;Stable Isotope Labeling;Stimulus;System;Testing;Therapeutic;Therapeutic Intervention;Tissues;Ubiquitin;ubiquitin-protein ligase

PROJECT_TITLE: The role of UBR5 in skeletal muscle atrophy and regrowth

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Neurodegenerative;Neurosciences;Opioids;Pain Research;Peripheral Neuropathy

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE To date, science has not produced a detailed elucidation of the circuitry involved in the physiological and emotional response to pain. The goal of this project is to identify the neural mechanisms through which surgical and neuropathic pain alters circuit function dynorphin-expressing neurons in the medial prefrontal cortex (mPFC). Because the mPFC is a key node in the emotional network of the brain, findings from this project should produce critical knowledge regarding the affective dimension of pain and pain disorders that could lead to novel strategies for analgesic therapies.

PI_NAMEs: SHEETS, PATRICK L (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Ablation;Action Potentials;Acute Pain;Address;Affect;Affective;affective disturbance;Affinity;Analgesics;Anxiety;Attenuated;Aversive Stimulus;Behavior;Behavior Control;behavioral plasticity;Binding;Brain;Calcium;Cells;chronic pain;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive deficits;comorbidity;Data;Dimensions;Dynorphins;Electrophysiology (science);Emotional;endogenous opioids;experience;Frequencies;Genetic;genetic manipulation;Genetic Transcription;Glutamates;Goals;Helping to End Addiction Long-term;hippocampal pyramidal neuron;Image;Impaired cognition;in vivo;in vivo calcium imaging;inflammatory pain;Injections;insight;kappa opioid receptors;Knowledge;Link;maladaptive behavior;Maps;Measurement;Medial;Mediating;Mental Depression;midbrain central gray substance;Midbrain structure;Minority;Modeling;Mood Disorders;motivated behavior;Mus;negative affect;Negative Valence;neuromechanism;Neurons;Neuropeptides;neurotransmission;new therapeutic target;Nociception;novel strategies;Opioid Antagonist;Opioid Peptide;optogenetics;Output;Pain;pain behavior;Pain Disorder;pain processing;pain reduction;painful neuropathy;Pathology;Pathway interactions;Phenotype;Physiological;Play;Population;Prefrontal Cortex;Procedures;Receptor Signaling;Reporting;Research;response;Role;Science;Sensory;sensory input;Signal Transduction;Slice;small hairpin RNA;Stimulus;Surgical incisions;Surgical Models;surgical pain;Synapses;System;Testing;tool;Transgenic Mice;Viral;Work

PROJECT_TITLE: Dissecting the role of mPFC dynorphin circuits in the modulation of different pain states

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ICN-Z (55)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Infectious Diseases;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Wastewater research and surveillance can provide early warning of the spread of known diseases of public health importance and inform public health responses, but it can also provide highly sensitive and potentially stigmatizing information, raising ELSI considerations, including how to manage return of results in a way that maximizes the benefits of wastewater research and public health surveillance and builds public trust while protecting privacy and avoiding the exacerbation of health inequities. We propose an innovative embedded ELSI research project that will directly impact the development and implementation of strategies for results dissemination from a statewide wastewater research and surveillance program in Texas. This project will collect critical empirical data from stakeholders and engage diverse members of the community to identify and develop strategies to address the ethical, legal, and social implications of return of results from public health research.

PI_NAMEs: DEEGAN, JENNIFER LEIGH;MCGUIRE, AMY L (contact)

PROGRAM_OFFICER_NAME: O'FALLON, LIAM

PROJECT_TERMS: 2019-nCoV;Academy;Address;Advisory Committees;Alcohol consumption;Attention;Bacteria;Biological Markers;Chemicals;Collaborations;Collection;Communication;Communities;community engagement;COVID-19 pandemic;Data;demographics;Development;Disclosure;Disease;Disease Outbreaks;Effectiveness;Environmental Pollutants;Epidemic;Ethical Issues;ethical, legal, and social implication;Ethics;evidence based guidelines;Exposure to;Feedback;Geography;Goals;Guidelines;Health;health determinants;health inequalities;Household;Human;Human Genome;illicit drug use;implementation strategy;improved;informant;Information Dissemination;innovation;Interview;Legal;Location;member;Municipalities;Outcomes Research;Participant;participant observation;pathogen;Personal Satisfaction;Population Surveillance;post-COVID-19;Prevalence;privacy protection;Process;programs;Protozoa;Public Health;public health research;public trust;Recommendation;Reporting;Research;Research Project Grants;Resources;response;Science;Sewage;Sexually Transmitted Diseases;social;Source;Stigmatization;Surveillance Program;Surveys;System;Testing;Texas;tool;Trust;United States;Virus;wastewater epidemiology;wastewater surveillance;working group

PROJECT_TITLE: Engaging community Members to Plan for dissemination Of Wastewater Epidemiology Results (The EMPOWER Study)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SEIR-P (80)]


NIH_SPENDING_CATS: Kidney Disease;Orphan Drug;Rare Diseases;Urologic Diseases

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE: The breakdown of hydroxyproline, a component of collagen, significantly contributes to the heightened synthesis of oxalate resulting in kidney stone formation as well as renal damage in those with primary hyperoxaluria, especially types 2 and 3. This proposal focuses on the development and optimization of drugs that will block this process and prevent such occurrences in those afflicted with these disorders.

PI_NAMEs: LOWTHER, W TODD (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Advanced Development;alpha ketoglutarate;animal data;Animal Model;Benchmarking;Binding;Biochemical;Biological Assay;Calcium Oxalate;Cell model;Chemicals;Chronic Kidney Failure;Collagen;Computational Biology;computational chemistry;Consumption;Crystal Formation;Data;Defect;Degradation Pathway;design;Development;Disease;effective therapy;efficacy evaluation;Enzymes;Excretory function;food consumption;Funding;Generations;Genes;Glycolates;glyoxylate;Hand;Health;high throughput screening;Hydroxyproline;improved;Individual;inhibitor;innovation;insight;Intellectual Property;Investments;Kidney;Kidney Calculi;Kidney Failure;Knock-out;Knockout Mice;Meat;Metabolism;mouse model;Mus;Nephrocalcinosis;novel;novel therapeutic intervention;Oxalates;oxalosis;Oxidoreductase;Pathway interactions;Patients;Pattern;Pharmaceutical Chemistry;Pharmaceutical Preparations;Plasma;pre-clinical;prevent;Prevention;Primary Hyperoxaluria;Process;process optimization;Production;programs;Property;rare genetic disorder;Recombinant Proteins;Recurrence;renal damage;Research;Risk;scaffold;Screening procedure;structural biology;Structure-Activity Relationship;timeline;urinary;Urine

PROJECT_TITLE: Hydroxyproline Dehydrogenase Inhibitors for the Treatment of Primary Hyperoxaluria

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Radiation Oncology

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE It has been recognized that there is a deficiency in adequately trained cancer physicians that will grow by 2025. The rapid nature of innovation in cancer research creates added challenges for trained medical, radiation, surgical, pediatric, and gynecologic oncologists who will form the next generation of researchers with backgrounds that support and optimize clinically relevant investigation. The Columbia Paul Calabresi Clinical Oncology Training Program (K12) will provide an ideal setting in which outstanding and comprehensive clinical research training can assure a cadre of future well-trained clinical investigators who will have the greatest impact on cancer care in the United States.

PI_NAMEs: HERSHMAN, DAWN  (contact);KACHNIC, LISA A.;LENTZSCH, SUZANNE

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acceleration;anti-cancer research;Basic Science;Biological;cancer care;cancer clinical trial;care delivery;career;career development;Clinical;Clinical Medicine;Clinical Oncology;Clinical Research;Clinical Trials;Communities;Community Clinical Oncology Program;Comprehensive Cancer Center;design;Direct Costs;Economics;Environment;Faculty;Fostering;Funding;Gender;Goals;Grant;Gynecologic Oncology;health equity;Herbert Irving Comprehensive Cancer Center;International;K-Series Research Career Programs;Malignant Neoplasms;Medical center;Medical Oncology;medical specialties;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Morbidity - disease rate;mortality;multidisciplinary;Nature;next generation;Observational Study;Outcomes Research;patient oriented;Patients;Pediatric Oncology;peer;Peer Review;Phase;Physicians;Population Sciences;Positioning Attribute;pre-clinical;preclinical study;Program Development;programs;prospective;Race;Radiation Oncology;Records;recruit;Reduce health disparities;Reporting;Research;Research Design;Research Training;Resources;Scientist;Site;skills;Surgical Oncology;Technology;Testing;Therapeutic;Training;Translational Research;Translations;underserved minority;Universities

PROJECT_TITLE: CUIMC Calabresi Clinical Oncology Career Development Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research

ORG_CITY: PHILADELPHIA

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Public Health Relevance This proposed R21 will provide an innovative examination of the causal impact of the Covid-19 mortality shock in France and the United States by combining important developments in the formal demography of cohort survivorship with a novel cohort discontinuity causal identification strategy. Findings from this study will break new ground by providing evidence on the impact of Covid-19 on cohort mortality and the degree to which Covid-19 may have offset or reversed pre-pandemic improvements in cohort survival. Our proposed analyses of data for France and the United States will provide credible causal evidence relevant to ongoing mortality research and debates on racial disparities, health systems, pension schemes, and population dynamics.

PI_NAMEs: GUILLOT, MICHEL  (contact);WU, LAWRENCE L.

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Adopted;Age;Birth;Black American;black/white disparity;caucasian American;cohort;Complement;COVID-19;COVID-19 impact;COVID-19 mortality;Data;Data Analyses;Death Rate;Demography;design;Development;Elements;Female;Fertility;France;Funding;Health system;improved;innovation;Life Expectancy;Longevity;male;Measures;mortality;Nature;novel;pandemic disease;Pensions;Population;Population Dynamics;post-COVID-19;pre-pandemic;public health relevance;Race;racial disparity;Research;Rest;Scheme;sex;Shock;Subgroup;survivorship;United States;Woman

PROJECT_TITLE: COVID-19 and Cohort Longevity: Causal Estimates from a Cohort Discontinuity Design

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Kidney Disease

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE We aim to develop the adult Danionella cerebrum, a close relative to zebrafish (Danio rerio), for optical-based studies of kidney-related disease mechanisms. This novel model will provide advantages and serve as an attractive alternative to existing animal models because its small size, optical transparency, and ease of use. Development of this novel adult disease model will facilitate future studies allowing for the in vivo visualization of cell signaling events and cell-cell interactions responsible for kidney disease initiation and resolution, or disease progression and development of end stage renal disease.

PI_NAMEs: LAM, PUI YING ;MANGOS, STEVE  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: 3D Print;Ablation;Acceleration;Acute;Acute Renal Failure with Renal Papillary Necrosis;Adult;Anatomy;Animal Disease Models;Animal Model;Animals;Biological;Biological Assay;Biological Models;Biology;Calcium;cell behavior;Cell Communication;cell injury;Cell Physiology;cell type;Cells;Cellular Stress;Cerebrum;Characteristics;Chemical Agents;Chemicals;Cicatrix;Complex;confocal imaging;cost;Cues;Custom;Data;Development;Disease;disease model;Disease Progression;DsRed;End stage renal failure;Environment;Equipment;Event;experience;Fibrosis;Filtration;Fishes;Fluorescence;Fluorescent Dyes;Foundations;Future;GC gene;Genes;Goals;Health;high resolution imaging;Histologic;Homeostasis;Image;Imaging Techniques;Immune;in vivo;in vivo imaging;Injury;Injury to Kidney;Innate Immune Response;Innate Immune System;insight;intravital imaging;Investigation;Ions;Kidney;kidney cell;Kidney Diseases;kidney imaging;Label;Lasers;Liquid substance;Location;Machine Learning;Macrophage;Measures;Mesonephric structure;Methodology;Methods;Microscopic;Modeling;multi-photon;Mutate;Natural regeneration;Nephrology;Nephrons;nephrotoxicity;neutrophil;novel;Operative Surgical Procedures;Optics;Organ;Pigmentation physiologic function;Pigments;Play;podocyte;Pronephric structure;Proteins;Publishing;Recovery;renal damage;Renal tubule structure;Reporter;Research;Research Personnel;Resolution;response;Role;serial imaging;Signal Transduction;Standardization;Surveys;Techniques;Technology;teleost;teleost fish;Therapeutic;Time;tool;Training;Transgenic Animals;Transgenic Model;Transgenic Organisms;Vertebrates;Visualization;Zebrafish

PROJECT_TITLE: Developing Danionella cerebrum as an adult vertebrate model to study kidney disease

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: AMES

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: IOWA STATE UNIVERSITY

ORG_STATE: IA

PHR: This proposal will examine the transcriptome-wide off-target effects of antisense oligonucleotides (ASOs) encompassing different modifications. Findings will have significance for developing future generation of ASO-based therapies for spinal muscular atrophy (SMA), one of the leading genetic causes of infant mortality.

PI_NAMEs: SINGH, RAVINDRA N (contact)

PROGRAM_OFFICER_NAME: NUCKOLLS, GLEN H

PROJECT_TERMS: Abbreviations;Affect;Antisense Oligonucleotide Therapy;Antisense Oligonucleotides;Base Pair Mismatch;Binding;Categories;cell type;Cells;Charge;Chemicals;Chemistry;clinical application;Code;Comparative Study;Compensation;Data;Disadvantaged;Disease;Event;Excision;exon skipping;Exons;FDA approved;Future;Future Generations;gene replacement;Genes;Genetic;Genetic Diseases;hnRNP A1;Human;Infant Mortality;Introns;Modification;Mutate;Mutation;Nature;oligonucleotide therapeutics;Oligonucleotides;Outcome;Pathway interactions;Patients;Pharmaceutical Preparations;phosphorothioate;Positioning Attribute;prevent;Prevention;promoter;Regulatory Element;Reporting;response;RNA;RNA Splicing;Role;Site;small molecule;SMN protein (spinal muscular atrophy);SMN1 gene;SMN2 gene;Spinal Muscular Atrophy;sugar;survival motor neuron gene;Therapeutic;Therapeutic Effect;Transcript;transcriptome;transcriptome sequencing;Transfection;Untranslated RNA;Validation;Vertebral column;Wheelchairs

PROJECT_TITLE: Transcriptome-Wide Effect of Therapeutic Antisense Oligonucleotides for the Treatment of Spinal Muscular Atrophy

STUDY_SECTION: MNG

STUDY_SECTION_NAME: Molecular Neurogenetics Study Section[MNG]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF EDUCATION

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Neurosciences;Pediatric;Pregnancy;Women's Health Research

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Despite 85% of women giving birth in their lifetimes, we know remarkably little about how the human brain changes during pregnancy and the consequences these changes on mood and cognition. The longitudinal project will provide insights into the neurobiological changes across pregnancy using multiple magnetic resonance imaging modalities, how hormonal shifts may influence these changes, and whether brain changes are associated with mood, cognition, and mental health. The findings will contribute fundamental knowledge on the human brain with translational relevance for the individuals and families affected by peripartum depression.

PI_NAMEs: HUMPHREYS, KATHRYN LEIGH (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acceleration;Address;Adrenal Gland Hyperfunction;Affect;Area;Bioethics;Birth;Brain;brain health;brain volume;Caregivers;Child;Cognition;Cognitive;cognitive function;cost;Data;depressive symptoms;design;Development;Diffusion Magnetic Resonance Imaging;Electroencephalography;Estradiol;Family;fetal;Foundations;Functional Magnetic Resonance Imaging;Generations;gray matter;Health Care Costs;Healthcare Systems;Hormonal;Hormonal Change;Hormones;Human;Hydrocortisone;imaging modality;imaging science;Impairment;Individual;Infant Health;innovation;insight;Investigation;Knowledge;Left;Life;Link;Longitudinal cohort;longitudinal design;Magnetic Resonance Imaging;Maternal-fetal medicine;Medicine;member;Mental Depression;Mental Health;Methods;Modality;Moods;MRI Scans;multidisciplinary;multimodal neuroimaging;multimodality;National Institute of Mental Health;negative affect;negative mood;Neurobiology;neuroimaging;Neuronal Plasticity;Neurosciences;Participant;Patient Self-Report;Pattern;Perinatal;perinatal mental health;peripartum depression;Personal Satisfaction;Persons;Policies;Population;Positioning Attribute;post pregnancy;Postpartum Period;Pregnancy;pregnant;Productivity;Progesterone;prospective;Protocols documentation;recruit;Regrets;Reporting;reproductive;Research;Research Project Grants;response;Rewards;Risk;Safety;Sampling;Scanning;Self Assessment;somatosensory;Stress;Structure;Testing;Testosterone;Thick;Time;United States National Institutes of Health;Vulnerable Populations;white matter;Woman;Work

PROJECT_TITLE: Longitudinal investigation of neuroplasticity during pregnancy using multiple imaging modalities

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Even though the emerging evidence-base for low-dose buprenorphine inductions is promising, these approaches are difficult to implement in the emergency department (ED) or outpatient setting. Existing evidence suggests extended-release buprenorphine injection may function as a low-dose induction due to its pharmacokinetic properties, which if safe will permit buprenorphine to be administered without waiting for withdrawal. We therefore propose to conduct a study to evaluate the safety and pharmacokinetics of using extended-release buprenorphine as a low-dose induction strategy and lay the groundwork for a randomized trial in the ED and outpatient setting.

PI_NAMEs: SUZUKI, JOJI  (contact)

PROGRAM_OFFICER_NAME: RAMEY, TANYA S

PROJECT_TERMS: Accident and Emergency department;Adherence;Agonist;Area;Blood specimen;Buprenorphine;buprenorphine treatment;care seeking;Clinic;Clinical Trials;combat;cue reactivity;design;Development;Dose;Double-Blind Method;Drug Kinetics;evidence base;experience;Fentanyl;Formulation;Funding;Guidelines;Hour;illicit opioid;improved;Incidence;Individual;Injections;Inpatients;Intervention;Intravenous;Measures;mortality;National Institute of Drug Abuse;novel;novel strategies;Opioid;Opioid agonist;opioid overdose;opioid use disorder;opioid withdrawal;Outpatients;Overdose reduction;Participant;Patients;Pharmaceutical Preparations;Plasma;Prevalence;prevent;primary outcome;Property;Protocols documentation;Public Health;Randomized;randomized trial;Randomized, Controlled Trials;Recommendation;Reporting;Research;response;Safety;safety assessment;secondary outcome;Serum;side effect;symptom treatment;Titrations;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Extended release buprenorphine as a novel low-dose induction strategy

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Mental Health

ORG_CITY: BERKELEY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: Project narrative Despite habits' essential role in everyday decision-making and in the cultivation of healthy lifestyles, and despite their relevance to many psychiatric conditions, cognitive neuroscientists have struggled to systematically and experimentally study how habits are formed and expressed. We hypothesize that habits can be robustly revealed when humans are induced to naturally disengage control in situations that mimic the hierarchical nature of their real-life decision-making, where choices made in a deliberate way are then executed in a more automated way. We will develop a new experimental protocol following this insight, investigate its ability to disentangle habits from control processes, and test the the validity of our hypothesis.

PI_NAMEs: COLLINS, ANNE G.E. (contact)

PROGRAM_OFFICER_NAME: ROSSI, ANDREW F

PROJECT_TERMS: Accounting;acute stress;addiction;Animals;Attention;Automobile Driving;Behavior;Behavioral;Characteristics;Chronic stress;Clinic;Clinical;Cognitive;cognitive control;Complex;Computer Models;cost;Cues;Decision Making;design;Diet;drug seeking behavior;Eating;Eating Disorders;Equilibrium;Exercise;experimental study;Failure;flexibility;Functional Imaging;Goals;habit learning;Habits;Handwashing;Health;healthy lifestyle;Human;Imaging Techniques;Impairment;Individual Differences;insight;Intervention;laboratory experiment;Left;Life;Light;Mental Health;Nature;neural;neural correlate;Obsessive-Compulsive Disorder;Outcome;overexpression;Participant;patient population;Patients;Pattern;Pharmaceutical Preparations;Play;pressure;Process;Protocols documentation;Psyche structure;Research;Research Personnel;Resources;response;Risk;Rodent;Role;Route;Series;Sleep;Testing;theories;Time;Tooth structure;Training;Translating;Walking;Work;young adult

PROJECT_TITLE: Habits as hierarchical building blocks

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative This project will test a multimodal neurotherapeutics intervention approach for treatment resistant depression. Specifically, we will test the combination of FDA-approved repetitive Transcranial Magnetic Stimulation (rTMS) with breath-focused attention training targeted towards suppression of default mode network activity. The R61 phase will focus on dose response for neural target engagement, while the R33 phase will replicate neural target engagement and also aim to show improvement in cognitive control and greater symptom response to treatment in a randomized controlled trial.

PI_NAMEs: MISHRA, JYOTI  (contact);RAMANATHAN, DHAKSHIN

PROGRAM_OFFICER_NAME: ANKUDOWICH, ELIZABETH

PROJECT_TERMS: active control;active control group;Affect;Affective;Algorithms;Anterior;anti-depressive agents;antidepressant effect;Attention;Behavioral;Brain region;Breathing;Cognition;Cognitive;cognitive control;cognitive function;cognitive neuroscience;Combined Modality Therapy;cost;Data;Depressed mood;depressive symptoms;digital;disability;Disease remission;Dose;Down-Regulation;effective therapy;electric field;Electroencephalography;Esthesia;FDA approved;Feedback;Foundations;Impairment;improved;Individual;Intervention;Link;Location;Major Depressive Disorder;Measures;Mental Depression;Methods;mindfulness;mindfulness intervention;Mindfulness Training;Modeling;Morbidity - disease rate;mortality;multi-component intervention;multimodality;neural;Neuronavigation;Outcome;Participant;Performance;Phase;Placebo Effect;Prediction of Response to Therapy;Predictive Factor;Prefrontal Cortex;Protocols documentation;Published Comment;Quality of life;Randomized;Randomized, Controlled Trials;repetitive transcranial magnetic stimulation;response;rumination;Sampling;selective attention;Source;Suicide;Symptoms;synergism;Testing;Training;treatment response;treatment-resistant depression;United States;Work

PROJECT_TITLE: Mindfulness Engaged Neurostimulation for Depression (MEND)

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-R (02)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Radiation Oncology

ORG_CITY: Columbus

ORG_DEPT: SURGERY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Narrative The overall goal of the Ohio State University K12 program is to effectively train and mentor faculty level early career investigators so that they are equipped to perform translational research that converts basic and population science discoveries into clinical studies for the prevention and treatment of cancer.

PI_NAMEs: CARSON, WILLIAM E. (contact);LAPALOMBELLA, ROSA

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: anti-cancer research;Appointment;Award;Basic Science;cancer prevention;cancer therapy;career;career development;Clinical;Clinical Oncology;Clinical Research;clinical translation;Clinical Trials;Collaborations;community building;Data;Dedications;design;Development;Development Plans;Diagnostic;Doctor of Philosophy;Dryness;Education;Educational Curriculum;Educational workshop;Enrollment;Ensure;Exhibits;experience;Female;Funding;Genomics;Goals;Grant;Individual;Investigational Therapies;investigator-initiated trial;K-Series Research Career Programs;knowledge base;Laboratories;Life;Malignant Neoplasms;Manuscripts;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Minority;Modality;Ohio;Oncology;Outcomes Research;Patients;peer coaching;Peer Review;Physicians;population health;Population Sciences;pre-clinical;Prevention;Process;programs;Publishing;Radiation Oncology;Research;Research Personnel;Resources;Scientist;skills;social;Source;Structure;success;Surgical Oncology;survivorship;targeted treatment;Teacher Professional Development;Therapeutic;Training;translational oncology;Translational Research;Translational trial;United States National Institutes of Health;Universities;Writing

PROJECT_TITLE: OSU K12 Training Grant in Oncology


NIH_SPENDING_CATS: Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: LAY ABSTRACT Understanding of the shared and distinct molecular bases of risk for neuropsychiatric disorders is necessary for developing prevention and treatment strategies. In this proposal, we quantify circRNA in PsychoENCODE cohort and other public datasets. We will use these to generate genetically regulated circRNA expression models and then apply these models to genome-wide association studies of Psychiatric disorders to understand shared and non-shared pathways of risk across linear and circ transcripts.

PI_NAMEs: DASKALAKIS, NIKOLAOS ;JAJOO, AARTI  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adoption;Architecture;Autopsy;Awareness;base;Big Data;biobank;Biological;Biological Process;Bipolar Disorder;Brain;Brain region;brain tissue;circular RNA;cohort;Collaborations;Complex;Data;Data Set;Databases;differential expression;Dimensions;Disease;endophenotype;Environment;Exhibits;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Code;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genotype;Goals;improved;Individual;innovation;insight;Investigation;Libraries;Major Depressive Disorder;Measures;Mediating;Mental disorders;Messenger RNA;Methods;Modeling;Molecular;molecular phenotype;neuron development;Neuronal Differentiation;neuropsychiatric disorder;neuropsychiatry;novel;Pathologic;Pathway interactions;Personal Satisfaction;Phenotype;Physiological;Post-Traumatic Stress Disorders;precision medicine;predictive modeling;Prevention strategy;Procedures;Protein Isoforms;psychiatric genomics;Psychiatric therapeutic procedure;psychogenetics;Research;Research Personnel;Resolution;Risk;RNA;RNA Splicing;Role;Schizophrenia;Signal Transduction;statistics;Structure;Synaptic plasticity;Synaptic Transmission;Techniques;Testing;Therapeutic Intervention;Tissues;Training;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;treatment strategy;Validation;Variant

PROJECT_TITLE: Utilizing circRNA transcriptomics for functional characterization of psychiatric GWAS


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: NEW YORK UNIVERSITY

PHR: PROJECT NARRATIVE Abnormalities in the calvaria (upper part of the skull) are a major class of birth defects in humans. The proposed project will provide detailed information on the genetic regulation of calvarial development with a focus on Fbn1, a human birth defect gene. The knowledge gained from this project can help devise new methods for diagnosis, treatment, and prevention of birth defects affecting the calvaria.

PI_NAMEs: JEONG, JUHEE  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: Affect;Age;Attention;Basic Science;Binding;Birth;Body System;bone;Bone Morphogenetic Proteins;Bone plates;Brain;Calvaria;candidate identification;Cardiovascular system;cell type;Child;Complex;Congenital Abnormality;Connective Tissue;craniofacial development;craniofacial structure;Craniosynostosis;cranium;Data;Defect;Development;Diagnosis;Equilibrium;Extracellular Matrix;FBN1;fibrillin;gene regulatory network;Gene set enrichment analysis;Generations;Genes;Genetic;genetic testing;Genetic Transcription;genome-wide;Glycoproteins;Goals;Growth Factor;Head;Human;improved;innovation;intercellular communication;Intervention;Investigation;Joint structure of suture of skull;Joints;Knowledge;Ligands;MADH2 gene;Maintenance;MAP Kinase Gene;MAPK3 gene;MAPK8 gene;Marfan Syndrome;Mechanics;Mediating;Mediator;Mesenchyme;Methods;Microfibrils;Modeling;Molecular;Morbidity - disease rate;Mus;mutant;Mutation;novel;Operative Surgical Procedures;orofacial development;Osteoblasts;osteogenic;p38 Mitogen Activated Protein Kinase;Pathogenesis;Pathogenicity;Pathway interactions;Phenotype;premature;prenatal;Prevention;Process;Proteins;Public Health;Regulation;Research;Risk;Role;Signal Pathway;Signal Transduction;Signal Transduction Pathway;skeletal;Skeletal system;Specificity;stem cells;Subcutaneous Tissue;Surgical sutures;Syndrome;System;Testing;Tissues;Transforming Growth Factor beta;Transforming Growth Factors;Translational Research;Western Blotting

PROJECT_TITLE: Characterization of calvarial defects in Marfan syndrome models

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Developmental Biology Study Section[CHHD-C]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Clinical Research;Lung;Nanotechnology;Neurosciences;Sleep Research

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Obstructive Sleep Apnea (OSA) is a common chronic condition that affects over a billion people worldwide. Current assessments of OSA severity and other physiological mechanisms require a burdensome in-lab polysomnography study, and while at-home sleep tests are becoming popular, they do not necessarily measure pertinent physiological signals. In this proposal, we will develop and validate a novel, nanotechnology enabled, adhesive-like wearable (SLEEPTRONIX) that is capable of measuring sleep and breathing patterns for multiple nights in addition to temperature and cortisol.

PI_NAMEs: KIM, YUN SOUNG ;PAREKH, ANKIT ASHOK (contact)

PROGRAM_OFFICER_NAME: YE, JANE

PROJECT_TERMS: Abdomen;Accelerometer;Adhesives;adverse outcome;Affect;Age;Air Movements;Algorithms;Ambulatory Monitoring;Apnea;aptamer;Arousal;Bandage;Binding;Biomedical Engineering;Breathing;cerebrovascular;Chest;Chronic;Circadian Rhythms;Clinical;Clinical Management;comorbidity;cost;Coupled;Data;Detection;Development;Devices;Diagnostic;digital;disorder risk;economic cost;electric impedance;Electrodes;Electroencephalography;endophenotype;Event;Excessive Daytime Sleepiness;Exclusion;Forehead;Frequencies;Functional disorder;Gel;Home;home test;Hydrocortisone;Hypertension;Hypoxia;improved;indexing;Individual;innovation;Intercellular Fluid;Intervention;Measurement;Measures;Medical Device;Medicine;Microfluidics;miniaturize;Monitor;Morbidity - disease rate;Movement;nanoGold;nanomembrane;Nanotechnology;Needles;Neurocognitive Deficit;Newly Diagnosed;novel;Obstructive Sleep Apnea;open source;Outcome;Oxygen;Oxygen saturation measurement;Pathway interactions;Patients;Pattern;Peripheral;Persons;Phase;Photoplethysmography;Physiological;Physiology;Polysomnography;portability;Reporting;respiratory;Risk;sensor;Severities;Severity of illness;sex;Signal Transduction;Silicones;Skin;Skin Temperature;Sleep;Sleep Apnea Syndromes;sleep physiology;sleep position;Sleep Stages;Spectrum Analysis;Stress;System;Technology;Temperature;Testing;Time;Traction;vibration;wearable device;wearable sensor technology;wireless sensor

PROJECT_TITLE: Development and use of SLEEPTRONIX for ambulatory assessment of sleep, temperature, and cortisol

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: PROJECT NARRATIVE: RELEVANCE TO PUBLIC HEALTH Abdominal aortic aneurysm (AAA) is a vascular disease that affects 5-10% of men and 1% of women over the age of 65, ranking as the thirteenth leading cause of death in the United States. Unfortunately, there are no pharmacological treatments available for the prevention of AAA progression and rupture; the only option for these patients is surgical intervention. The purpose of this project is to examine the potential for healing programs in the platelets and macrophages of the unique Acomys regenerative mouse model in order to develop viable therapeutic options in human AAA.

PI_NAMEs: OWENS III, ALBERT PHILLIP (contact)

PROGRAM_OFFICER_NAME: GAO, HONGWEI

PROJECT_TERMS: Abdominal Aortic Aneurysm;Acceleration;Acomys;Address;Affect;African;Age;American;Aneurysm;Animal Model;Aorta;Aortic Aneurysm;Aortic Diseases;Apical;Attenuated;Award;Biology;Blood Platelets;Cardiovascular Diseases;Cardiovascular system;Cause of Death;CCL7 gene;cell regeneration;Cells;chemokine;Chemotaxis;Chest Pain;Chronic;Cicatrix;Clinical;Communication;cytokine;Data;Death Rate;Development;Diameter;Disease;Elderly;Failure;Fibroblasts;Fibrosis;flexibility;Gender;Genetic;Goals;Growth;healing;Healthcare;House mice;Human;human old age (65+);improved;in vivo;in vivo regeneration;Incidence;Injury;innovation;insight;interdisciplinary collaboration;Kidney;Knowledge;Leukocytes;Life;Life Style;Lower Extremity;Macrophage;Macrophage Activation;male;Mammals;Mediating;Mediator;Medical;Medical Assistance;men;Mission;Modeling;Monitor;monocyte;Morphogenesis;mortality;mouse model;Movement;Mus;Myocardial Ischemia;Myofibroblast;Natural regeneration;Nature;novel;novel strategies;Operative Surgical Procedures;Organ;Organogenesis;Patients;Pattern;Persons;pharmacologic;Pharmacological Treatment;Phenotype;Platelet Activation;Platelet aggregation;Play;Polyphosphates;Population;prevent;Prevention;programs;Property;Proteome;Public Health;regenerative;Regulation;renal ischemia;repaired;Research Proposals;Risk Factors;Role;Rupture;Ruptured Abdominal Aortic Aneurysm;sedentary lifestyle;Signal Pathway;Signal Transduction;Site;stem cells;Stromal Cell-Derived Factor 1;Sudden Death;Testing;Therapeutic;Thrombus;Time;Tissue Banks;tissue regeneration;Tissues;Tobacco use;tool;transcriptome;Transgenic Organisms;Translating;ultrasound;underserved area;United States;Vascular Diseases;Vertebrates;western diet;Woman;Work;wound healing

PROJECT_TITLE: Defining Novel Roles of Platelets and Macrophages in the Healing of Abdominal Aortic Aneurysm

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Lung

ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Respiratory viruses are a major public health problem, with SARS-CoV-2 causing more than 1.1 million deaths in the U.S. since 2020, and influenza typically causing hundreds of thousands of hospitalizations each winter season. Interferons are proteins made by the body that protect against respiratory viruses, but regulation of this response is critical, because excessive interferons can cause tissue damage. This project will define the role of a unique type of interferon in the respiratory tract in fine-tuning the balance between defense and tissue damage, and this new understanding will ultimately inform new strategies to prevent respiratory virus infections.

PI_NAMEs: FOXMAN, ELLEN FLESCHER (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: 2019-nCoV;Adult;Air;airway epithelium;Anti-viral Response;Asthma;Atlases;Automobile Driving;bronchial epithelium;Cell Culture Techniques;cell type;Cells;Cessation of life;Child;Childhood;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;COVID-19 screening;COVID-19 susceptibility;cytokine;Data;Defense Mechanisms;Development;Disease;Dose;Epithelial Cells;Epithelium;Equilibrium;female reproductive tract;Gene Expression;gene induction;Genes;Genetic;Goals;Hospitalization;Hospitals;Host Defense;Human;human subject;immune activation;immunopathology;Impaired wound healing;Infection;Inflammation;Inflammatory;Influenza;Influenza A virus;influenza infection;insight;Interferon Type I;Interferons;Knock-out;Knowledge;Laboratory Study;Liquid substance;Messenger RNA;Modeling;mRNA Expression;Mucous Membrane;Mus;nasopharyngeal swab;Nasopharynx;Nose;novel;novel strategies;Pattern;prevent;Production;protein expression;Proteins;Public Health;Regulation;Reporting;respiratory;respiratory infection virus;Respiratory Mucosa;Respiratory System;respiratory virus;response;Rhinovirus;Risk;risk minimization;Role;Sampling;Seasons;Signal Pathway;System;Testing;Tissues;transcriptome sequencing;transcriptomics;Viral;Viral Load result;Viral Respiratory Tract Infection;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Interplay between canonical and non-canonical interferons in defense against respiratory viruses

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

PHR: The cerebellum is an evolutionary old brain area, whose role in sensorimotor integration and motor learning is well studied. However, little is known about cerebellar interactions with other brain centers, such as the neocortex, although emerging evidence points to a role in cortical development, cognitive control and related disorders. Here, we propose to study whether cerebellar climbing fibers – known to provide an instructive signal in cerebellar learning – are able to similarly supervise cortical plasticity, using receptive field plasticity in the mouse barrel cortex as a test case.

PI_NAMEs: HANSEL, CHRISTIAN ROBERT (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: Address;Affect;Anatomy;Area;awake;barrel cortex;Brain;Calcium Signaling;Cell Nucleus;Cellular Structures;Cerebellar Cortex;Cerebellar Nuclei;Cerebellum;cognitive control;Complex;Data;designer receptors exclusively activated by designer drugs;Development;Disease;Disinhibition;experimental study;Fiber;follow-up;Frequencies;genetic approach;Goals;hippocampal pyramidal neuron;Image;Impairment;Individual;Inferior;inhibitory neuron;interest;Interneurons;Laboratories;Lateral;Learning;Light;Long-Term Depression;Measures;Mediating;motor learning;Mus;Nature;Neocortex;neocortical;Neurons;novel;Olives - dietary;optical imaging;optogenetics;Parvalbumins;Pathway interactions;Physiologic pulse;Population;Proxy;Purkinje Cells;Pyramidal Cells;receptive field;recruit;Recruitment Activity;Rewards;Role;Sensory;Signal Pathway;Signal Transduction;somatosensory;Stimulus;Subgroup;supervised learning;Synapses;System;Testing;Thalamic Nuclei;theories;time interval;two photon microscopy;two-photon;Ventral Tegmental Area;Vibrissae;Weight;Work

PROJECT_TITLE: Instructive climbing fiber signals outside the cerebellum

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


NIH_SPENDING_CATS: Biotechnology;Gene Therapy;Genetics;Hematology;Orphan Drug;Prevention;Rare Diseases

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: NARRATIVE This project focuses on a heritable ectopic calcification disorder, pseudoxanthoma elasticum (PXE), for which there is no effective or specific treatment currently available. The proposed studies will utilize previously established rodent models as a platform to apply novel AAV-based ABCC6 gene therapy targeting the underlying genetic cause of ectopic calcification in PXE. Successful studies in animals as proposed in this application could then lead to a new treatment strategy for clinical trials in patients with PXE.

PI_NAMEs: LI, QIAOLI  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: adeno-associated viral vector;advocacy organizations;Alkaline Phosphatase;Alleles;Animals;autosome;bench to bedside;Biological Availability;calcification;calcification inhibitor;Calcinosis;calcium phosphate precipitation;Cardiovascular system;Characteristics;Clinical;clinical care;Clinical Management;Clinical Trials;Codon Nucleotides;Collaborations;college;Complementary DNA;Connective and Soft Tissue;Connective Tissue;Data;Dependovirus;Deposition;Development;Diphosphates;Disease;Disease susceptibility;Dose;Durapatite;effective therapy;Elastic Fiber;Environmental Risk Factor;Enzymes;extracellular;Eye;gene therapy;gene-targeted therapy;Genes;Genetic;Goals;Hematologist;Hematology;Hemophilia A;Hemorrhage;Heritability;Homeostasis;Human;Hydroxyapatites;improved;In Vitro;inhibitor;innovation;International;international center;intravenous injection;Link;Liver;London;loss of function mutation;Loss of Heterozygosity;Mediating;Membrane;Metabolic;Modality;Molecular Target;Morbidity - disease rate;mortality;mouse model;Mus;Mutate;Mutation;novel;novel therapeutic intervention;Oral;Other Genetics;Outcome;Pathologic;Pathology;Patient advocacy;Patients;pharmacologic;phosphatase inhibitor;Physiological;Plasma;Play;pre-clinical;preclinical development;preclinical study;prevent;Prevention;protein expression;Protein phosphatase;Proteins;prototype;Pseudoxanthoma Elasticum;Rattus;Recombinants;Research;response;Rodent Model;Role;Satellite Viruses;Serotyping;Skin;small molecule inhibitor;System;Testing;therapeutic development;Time;Tissues;Tropism;Universities;vector;Viral;Viral Vector;Wild Type Mouse

PROJECT_TITLE: Gene Therapy for PXE: Breaking the Barrier of Ectopic Calcification

STUDY_SECTION: TAG

STUDY_SECTION_NAME: Therapeutic Approaches to Genetic Diseases Study Section[TAG]


FUNDING_MECHANISM: RESEARCH CENTERS

NIH_SPENDING_CATS: Aging

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This supplement RFA does not require a project narrative since it is the same as the parent award.

PI_NAMEs: AUSTAD, STEVEN N. (contact);BUFORD, THOMAS W

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Adipose tissue;Aging;Alabama;Animal Model;Animals;Bioenergetics;Biology of Aging;Body Composition;Brown Fat;Cells;Collaborations;Communities;comparative;Complex;Country;Data Analytics;Data Set;Education;energy balance;Expenditure;experimental study;Fishes;fly;Fostering;Geroscience;Health;health assessment;innovation;Instruction;Intake;Link;Longevity;Mammals;Metabolic;metabolic abnormality assessment;Metabolism;metabolomics;Methodology;Mitochondria;Mitochondrial DNA;Modeling;Modernization;Mus;novel;Nuclear;Nutrient;Organelles;Oxidative Stress;parent project;programs;Research;research and development;Research Infrastructure;Research Personnel;Resources;Shock;Signal Transduction;Technology;Temperature;Tissues;Training;Twin Multiple Birth;Universities;Variant;Whole Organism

PROJECT_TITLE: Comparative Bioenergetics of Aging


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project Narrative Vision depends on a complex network of brain regions, but little is known about visual processing in higher- order, multimodal areas of the medial temporal lobes (MTL). In our prior work we established that the MTL plays a critical role in visual perception of complex materials. However, the specific functional role (or roles) that the MTL plays in supporting visual perception is just beginning to be understood, and there are now several competing theories about the role that different regions within the MTL, such as the different hippocampal subfields, play in visual perception. The proposal aims to determine how regions within the MTL contribute to complex scene perception and visual working memory using a combination of studies examining patients with focal lesions to specific MTL subregions, high-resolution functional magnetic resonance imaging (fMRI), eye monitoring methods, and several novel psychophysical paradigms. The studies aim to understand how the brain supports high-level visual processes, and will provide a more complete characterization of the cognitive deficits associated with temporal lobe damage suffered by various psychiatric and neurological populations, which is essential in the development of targeted rehabilitation strategies that better capitalize on both the disrupted and the spared functions in such patients.

PI_NAMEs: YONELINAS, ANDREW P (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Address;age related changes;aging population;Alzheimer's Disease;Alzheimer's disease patient;Anterior;Area;Automobile Driving;Behavioral;Brain;Brain imaging;Brain region;Cognitive;Cognitive deficits;Color;Complex;design;Detection;Development;discrimination task;Disease;Environment;Episodic memory;Event;Eye;Eye Movements;Functional Magnetic Resonance Imaging;gaze;Goals;healthy aging;Hippocampus;Human;imaging modality;Knowledge;Lesion;medial temporal lobe;Mental Depression;Methods;Modeling;Monitor;multimodality;neural;neural circuit;Neurologic;novel;ophthalmic examination;patient population;Patients;Pattern;Perception;Performance;Peripheral;Play;Population;Process;Protocols documentation;Psychophysics;rehabilitation strategy;Resolution;Role;sample fixation;Sampling;Scanning;Schizophrenia;Series;Short-Term Memory;Stimulus;Temporal Lobe;Testing;theories;Time;Vision;Vision Tests;Visual;visual cognition;visual control;visual discrimination;visual information;Visual Perception;visual processing;Visual System;visual tracking;Work

PROJECT_TITLE: Visual perception and the medial temporal lobes


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Regenerative Medicine;Rehabilitation;Stem Cell Research;Stem Cell Research - Embryonic - Human;Transplantation

PHR: Project Narrative The disruption of connections between the eye and the brain causes irreversible vision loss. The proposed research will develop the novel use of stem cell therapies and nerve relays to restore the lost connections between the eye and the brain and enable whole eye transplants. This is relevant to public health because restoring vision and reversing blindness would significantly improve the lives of individuals blinded by optic neuropathies or retinal disease.

PI_NAMEs: DO, JIUN LAP (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adult;Axon;axon growth;axon guidance;axon regeneration;behavioral outcome;blind;Blinded;Blindness;Blood Vessels;Brain;Brain-Derived Neurotrophic Factor;Cell Nucleus;circadian;Contralateral;Cues;Dependovirus;design;Development;Ephrin Receptor EphB1;experimental study;Eye;eye transplantation;Foundations;functional outcomes;functional restoration;Future;Genetic;genetically modified cells;Goals;Grant;Histologic;Immune;improved;in vivo;injured;innovation;Ipsilateral;Knowledge;long term recovery;Measures;Methods;Modeling;Modification;myelination;Natural regeneration;Nerve;nerve stem cell;neural circuit;neural graft;Neurologic;Neurons;Neurophysiology - biologic function;Neuropilin-1;neurotrophic factor;novel;Optic Chiasm;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;optic nerve regeneration;Optic Nerve Transections;Optic tract structure;Outcome;Pathway interactions;Patients;Property;Public Health;Rattus;receptor;Recovery;Recovery of Function;regenerative approach;Regenerative research;regenerative therapy;Research;response;Retinal Diseases;Retinal Ganglion Cells;Rodent;Role;sight restoration;soft tissue;Spinal cord injury;stem cell biology;stem cell therapy;stem cells;superior colliculus Corpora quadrigemina;Synapses;System;Technology;Testing;therapeutic development;therapy development;Transfection;translational impact;Transplantation;Viral;Vision;visual stimulus;Visual System;Visually Impaired Persons;Work

PROJECT_TITLE: Optic Nerve Relays for Vision Restoration and Advancement Optic Nerve Regeneration Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Precision Medicine;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with higher incidence and worse clinical outcomes for non-Hispanic Black (NHB) and Hispanic women compared to non-Hispanic White women (NHW), even when risks are adjusted for clinical and socio-economic factors. We recently identified four TNBC subtypes robustly prognostic for therapy response based on BRCA1/2 gene status and the level of expression of an immune-related gene signature. Here, we propose to determine the prevalence of these distinct molecular subtypes in NHW, NHB, and Hispanic TNBC patients to assess whether they disproportionally occur in specific racial/ethnic groups and may therefore contribute to the observed disparities in therapy response outcomes.

PI_NAMEs: MENENDEZ, ALVARO ;MENGHI, FRANCESCA  (contact)

PROGRAM_OFFICER_NAME: SHARMAN, ANU

PROJECT_TERMS: Accounting;Address;Affect;Age;aggressive breast cancer;Archives;Biological;Biological Assay;Biological Factors;biological specimen archives;Biology;Black race;black women;brca gene;BRCA mutations;BRCA1 gene;breast cancer diagnosis;Breast Cancer Patient;Cancer Biology;cancer health disparity;cancer subtypes;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Data;cohort;Community Healthcare;Community Hospitals;Custom;Data Set;design;Diagnosis;Disease;Disparity;Disproportionately impacts women;DNA;ethnic difference;ethnic disparity;Ethnic Origin;Ethnic Population;Evolution;Frequencies;Funding;Future;Gender;Gene Expression Profile;gene panel;Genes;genetic signature;Genetic Transcription;Healthcare;Healthcare Systems;High Prevalence;Hispanic;Hispanic ancestry;Hispanic Women;Histologic;Histology;Housekeeping Gene;Hypermethylation;Immune;immune cell infiltrate;Immune signaling;Immunotherapy;improved;In complete remission;Incidence;Individual;insight;Institution;interest;Knowledge;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;melting;Methylation;Molecular;molecular subtypes;Molecular Target;mutant;Not Hispanic or Latino;novel;Outcome;Output;Pathogenicity;Pathologic;patient population;patient stratification;Patients;personalized therapeutic;Platinum;Play;Prevalence;Process;Prognosis;prognostic;prognostic value;promoter;Prospective Studies;Race;racial difference;racial disparity;racial population;Reporting;Resolution;response;Retrospective cohort;Risk Adjustment;RNA;Sampling;Secure;Socioeconomic Factors;Specimen;standard of care;Subgroup;targeted sequencing;targeted treatment;Technology;Testing;The Cancer Genome Atlas;therapy outcome;Translating;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor-infiltrating immune cells;Variant;White Women;Woman;women patients

PROJECT_TITLE: Assessing molecular predictors of triple negative breast cancer therapeutic response in Black, White, and Hispanic patients in a community healthcare system

STUDY_SECTION: BMCD

STUDY_SECTION_NAME: Basic Mechanisms of Cancer Health Disparities Study Section[BMCD]