NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Prevention;Women's Health Research

ORG_CITY: JACKSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MISSISSIPPI MED CTR

ORG_STATE: MS

PHR: Narrative This proposal is to advance the Mississippi Center of Excellence in Perinatal Research (MS CEPR) COBRE at the University of Mississippi Medical Center into Phase 2. Perinatal research encompasses the study of disease states that have their etiology during gestation and early post-natal development that result in long term consequences in the mother and offspring across their lifespans. The long term goal is to develop an nationally recognized, sustainable MS CEPR dedicated to reducing health care disparities and improving the lives of women and their offspring, especially in Mississippi, through discovery, innovation, and translation to prevent and reduce death and disability from perinatally-induced diseases.

PI_NAMEs: RECKELHOFF, JANE F (contact)

PROGRAM_OFFICER_NAME: REVILLEZA, MARIA

PROJECT_TERMS: Acceleration;adult obesity;Aging;Animals;Basic Science;Behavioral;Biological Factors;Biomedical Research;Black race;Cardiovascular Diseases;Cardiovascular system;career development;Caucasians;Center for Translational Science Activities;Centers of Research Excellence;Cessation of life;Clinical;clinical center;Clinical Research;Collaborations;confocal imaging;Core Facility;Dedications;Development;developmental disease;disability;Discipline;Disease;disease disparity;disorder risk;Education;Environment;Equipment;Etiology;Extramural Activities;Faculty;Fluorescence-Activated Cell Sorting;Fostering;Funding;Goals;Grant;Health;health care disparity;health disparity;Human;Hypertension;improved;Infrastructure;innovation;interest;International;Kidney;Kidney Diseases;Laboratories;Life;life span;Low Birth Weight Infant;Low Prevalence;Medical center;Mentors;Metabolic;Metabolic Diseases;minority investigator;Mississippi;Mitochondria;Morbidity - disease rate;mortality;Mothers;multidisciplinary;Neurosciences;obesity development;offspring;Peer Review;Perinatal;perinatal environment;Phase;Pilot Projects;Population;population health;Population Research;postnatal development;Pre-Eclampsia;Pregnancy;Pregnancy Outcome;prevent;Productivity;Program Development;programs;Publications;recruit;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Proposals;Research Support;Scientist;Secure;Services;Societal Factors;study population;Translational Research;Translations;Underrepresented Minority;United States;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Mississippi Center of Excellence in Perinatal Research, Phase 2:Supplement:  Hypertension in PCOS women: Interplay between Biological and Societal Factors.


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DERMATOLOGY

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Aging is a major risk factor for both Alzheimer’s Disease development in the brain and loss of Merkel cell touch receptors in the skin. This Administrative Supplement proposal will investigate convergent mechanisms that underlie these two age-related diseases. If proven, our application will unlock new avenues of investigation for the Alzheimer’s field and establish the skin Merkel cell pool as a prognostic factor for Alzheimer’s risk.

PI_NAMEs: OWENS, DAVID MICHAEL (contact)

PROGRAM_OFFICER_NAME: KATIYAR, PRAGATI

PROJECT_TERMS: Acceleration;Administrative Supplement;Adult;Affect;Age;age related;age related decline;age-related disease;Aging;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer's disease therapy;Amyloid;Antibodies;Atlases;Behavior;Brain;brain tissue;Cell Count;cell type;Cells;Central Nervous System;Cholinesterase Inhibitors;Communication;comorbidity;Cutaneous;Data;Dementia;Development;Disease;Eating;epithelial stem cell;Etiology;FDA approved;Future;Glutamates;Goals;Grant;Human;human old age (65+);Impaired cognition;Inflammation;Infusion procedures;Investigation;Laboratories;life span;Maintenance;Masks;Mechanoreceptors;Medical;Merkel Cells;Molecular;mouse model;multiple omics;Mus;Mutation;Nerve Degeneration;Neurobehavioral Manifestations;Neurosecretory Systems;novel;Onset of illness;Pathology;Patients;Perception;Prognostic Factor;Proteins;receptor;Reporting;Resolution;Risk Factors;Role;side effect;Skin;Skin Tissue;somatosensory;stem cell function;Symptoms;Tactile;Testing;Touch sensation;Transgenic Mice;Utrophin

PROJECT_TITLE: Investigating the role for Utrophin in age-related decline of the Merkel lineage

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Contraception/Reproduction;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Enhancing Policy Impact for Reproductive Health Equity (EnPIRHE) Project Narrative- 3 sentences Individuals can be reluctant to obtain sensitive health services because of insurance and billing confidentiality concerns, and resulting gaps in care worsen population health overall and health inequities. Massachusetts’ PATCH law is one of only a handful of state-level laws that afford privacy protections for individuals using insurance to access sensitive services. The EnPIRHE study will estimate the proportion of insured dependents who refrain from using their insurance for sensitive services even in the setting of legal protections, quantitatively assess population knowledge of the PATCH law, and qualitatively assess barriers to use of the law’s protections among different demographic subgroups.

PI_NAMEs: JANIAK, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: ableism;abortion;Affect;Age;Attitude;barrier to care;Black race;Black, Indigenous, People of Color;Caring;Chronic Disease;cis-female;Communities;Confidentiality of Patient Information;Constitution;Data;design;Diagnosis;disability;Economics;Equity;falls;Family member;Fright;Future;gender nonconforming;Goals;Health;Health Benefit;health care availability;health care service;health care service organization;health equity;health inequalities;Health Insurance;health organization;Health Personnel;Health Policy;Health Services;Health Services Accessibility;Healthcare;Healthcare Systems;Improve Access;improved;Indigenous;Individual;Infrastructure;innovation;Insurance;Insurance Coverage;insurance plan;Intention;interest;Intervention;Interview;Knowledge;Laws;Legal;Literature;low socioeconomic status;marginalization;marginalized population;Massachusetts;Methods;Minority;novel;Paper;Parents;patient oriented;patient population;patient privacy;Patients;Pattern;people of color;Personal Satisfaction;Persons;Planned Parenthood Federation of America;Policies;Population;population health;Preventive service;Privacy;privacy protection;Privatization;Proliferating;Provider;Public Health;racism;recruit;Reproductive Health;Reproductive Health Services;Risk;service utilization;Services;sexual and reproductive health;Sexuality;social;Spouses;State Government;Statutes and Laws;Stigmatization;Structure;Subgroup;Suggestion;Supreme Court Decisions;Surveys;Time;transgender;United States;uptake;Women's Health;World Health Organization

PROJECT_TITLE: Confidentiality in use of health insurance coverage for reproductive health services

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-D (90)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Rare Diseases;Scleroderma

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: PROJECT NARRATIVE Scleroderma is an immune-mediated disease of the connective tissue, characterized by fibrosis of the skin and underlying organs, which has the highest mortality rate of any rheumatic disorder; there is no cure and only limited targeted treatments. We hypothesize that T cells interact with fibroblasts in the skin to regulate the gene programs of healthy tissue and that pathogenic T cell cytokines promote dysregulated fibroblast gene expression changes leading to fibrosis and organ failure. This proposal will utilize innovative techniques such as spatial transcriptomics and organotypic skin culture to fill critical knowledge gaps about T cells during disease and overcome existing technical hurdles in the field to inform future therapeutics for scleroderma. 1

PI_NAMEs: MORAWSKI, PETER A (contact)

PROGRAM_OFFICER_NAME: RICE, JEFFREY S

PROJECT_TERMS: 3-Dimensional;Address;Affect;Architecture;Autoantibodies;Automobile Driving;Biology;Blocking Antibodies;Blood;CD4 Positive T Lymphocytes;Cell Communication;Cell Physiology;Cells;Collagen;Connective Tissue Diseases;Cutaneous;Cutaneous sclerosis;cytokine;Data;Death Rate;density;Deposition;Dermal;Development;Disease;Dissection;Drug Screening;Engineered skin;Experimental Models;experimental study;Fibroblasts;Fibrosis;Foundations;Frequencies;Functional disorder;Future;Gene Expression;Generations;Genes;genetic signature;Genetic Transcription;Goals;Heterogeneity;Homeostasis;IL17 gene;Immune;Immune signaling;Immunosuppression;improved;In Situ;in vivo;Infection;innovation;Interleukin-13;interleukin-22;Interleukin-4;Knowledge;LGR5 gene;Link;Maintenance;Mediating;Mediator;Modeling;mortality;novel;Organ;Organ failure;Outcome;Pathogenicity;Pathology;Patients;Physiological;Population;pre-clinical;Predisposition;Production;programs;Reagent;receptor;Recombinant Cytokines;reduce symptoms;Regulation;Research Project Grants;Role;Scleroderma;Serum;single cell analysis;Skin;skin fibrosis;Skin Physiology;standard of care;Systemic Scleroderma;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;therapeutically effective;Tissues;transcriptional reprogramming;transcriptomics;Vascular Diseases;Work

PROJECT_TITLE: T cell-mediated control of dermal fibroblast gene programs and dysfunction in scleroderma


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Electronic Nicotine Delivery Systems;Lung;Lung Cancer;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE (RELEVANCE) As much as 50-60% of cancer is preventable, and tobacco is by far the leading preventable cause of cancer, accounting for one-third of cancer mortality. Interventions to stop adolescent e-cigarette use “vaping” are important for cancer prevention, as those who vape are almost 4 times more likely to smoke cigarettes. Lessons learned from developing effective social media interventions for adolescents can also be applied to enhance other cancer-related communication efforts to improve equity in cancer control and treatment.

PI_NAMEs: LING, PAMELA MAY (contact)

PROGRAM_OFFICER_NAME: RODITIS, MARIA LEIA

PROJECT_TERMS: Abstinence;Accounting;Address;Adolescent;Adolescent and Young Adult;Adoption;Advertising;Age;aged;arm;Asthma;California;Cancer Control;cancer prevention;cancer therapy;Cannabis;cardiovascular effects;Cellular Phone;cigarette smoke;cigarette smoking;Clinical Trials;Communication;community organizations;community partners;COVID-19 pandemic;Data;Devices;e-cigarette cessation;Education;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;effectiveness/implementation design;efficacy trial;Electronic cigarette;electronic cigarette use;Epidemic;Equity;Evaluation;evidence base;Evidence based intervention;experience;flexibility;Future;gender minority;Health;High School Student;human centered design;implementation barriers;implementation evaluation;implementation science;improved;information gathering;innovation;Instagram;Intervention;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Media Intervention;Middle School Student;mortality;multidisciplinary;Nicotine;novel;Participant;Pediatrics;Population;pre-pandemic;Prevalence;Preventable cancer cause;programs;Provider;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;research to practice;Resources;return to use;Risk;school district;Schools;sex;Sexual and Gender Minorities;sexual minority;smoking cessation;smoking initiation;Social Marketing;social media;Specific qualifier value;Speed;Subgroup;success;Support Groups;Testing;Tobacco;tobacco control;tobacco prevention;tobacco products;Tobacco use;Tobacco Use Cessation;Training;Translational Research;treatment arm;uptake;vaping;Youth

PROJECT_TITLE: Social media support groups for adolescent vaping cessation

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RPRB-6 (M2)]


ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Narrative This project will develop a new class of range modulators to enable ultra-fast dose delivery for FLASH particle therapy. The approach will couple an innovative 3D printing technique to design and explore modulating devices with varying densities, permitting modular assembly, volumetric irradiation, and patient-specific plan construction.

PI_NAMEs: TEO, BOON-KENG KEVIN  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;3D Print;Advanced Malignant Neoplasm;Air;Algorithms;Area;Biological;cancer therapy;Characteristics;Clinical;clinical implementation;Clinical Treatment;Clinical Trials;Complex;Cyclotrons;Defect;density;design;Development;Devices;Dose;Dose Rate;Electrons;Filament;flexibility;Freedom;Geometry;Height;improved;Individual;innovation;irradiation;Maps;Measures;Methods;Modality;Monte Carlo Method;Normal tissue morphology;novel;particle beam;particle therapy;Patients;Phase;Positioning Attribute;preclinical study;Printing;proton beam;proton therapy;Protons;Radiation;Radiation therapy;Research;Resolution;Scanning;Solid;Spottings;Structure;Synchrocyclotron;System;Techniques;Technology;Testing;Thick;Toxic effect;treatment planning;tumor;Uncertainty;Validation;Width;Work;X-Ray Computed Tomography

PROJECT_TITLE: Development of Novel Heterogeneous Range Modulators for FLASH Particle Therapy

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: THOMAS JEFFERSON UNIVERSITY

PHR: Spinal and bulbar muscular atrophy (SBMA) is one of 9 polyglutamine diseases that are part of a larger family of neurodegenerative diseases characterized by protein misfolding and accumulation; these diseases include Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Understanding molecular mechanisms of disease has the potential to unveil new and innovative approaches to therapy. We propose here to understand how a specific modification of the androgen receptor (AR) in SBMA is regulated so that we can manipulate it for therapeutic potential.

PI_NAMEs: MERRY, DIANE E (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Acetylation;Adult;AF2;Alanine;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Androgen Receptor;androgenic;Androgens;Arginine;Azides;Binding;Biochemical;Biotinylation;Brain Stem;Cell model;Cell Nucleus;Consensus;crosslink;Data;Development;Dimerization;Disease;disease model;Evaluation;Event;experimental study;Family;Genetic;Half-Life;Hormones;Huntington Disease;In Vitro;in vivo;Inherited;innovation;insight;knock-down;Ligands;Link;Lysine;Malignant neoplasm of prostate;Manuscripts;Mediating;Metabolism;Methylation;Modeling;Modification;Molecular;Molecular Conformation;Motor Neurons;mouse model;Muscular Atrophy;mutant;Mutation;Neurodegenerative Disorders;Neuromuscular Diseases;neuron loss;Neuronal Dysfunction;neuroprotection;novel;novel therapeutics;Nuclear;Nuclear Inclusion;overexpression;Parkinson Disease;Pathogenesis;Pathology;Pathway interactions;Patients;Peptides;pharmacologic;Phenotype;Phosphorylation;Phosphotransferases;polyglutamine;Post-Translational Protein Processing;Preparation;prevent;protein crosslink;protein misfolding;Proteins;Publishing;receptor;Receptor Aggregation;response;Role;Serine;serine receptor;Site;spinal and bulbar muscular atrophy;Spinal Cord;Spinocerebellar Ataxias;Streptavidin;Therapeutic;therapeutic target;tool;Toxic effect;Transgenic Mice;Ubiquitination;Validation

PROJECT_TITLE: The mechanism and role of androgen receptor Serine 16 phosphorylation in SBMA

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Dental, Oral, and Craniofacial Disease;Electronic Nicotine Delivery Systems;Infectious Diseases;Natural Products;Pediatric;Prevention;Substance Misuse;Tobacco

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Electronic nicotine delivery systems (ENDS) are increasingly popular among adolescents and young adults for “vaping” of nicotine and cannabis products and are often considered “healthier alternatives” but may have the same negative impact on oral health, including tooth decay, as previously reported for tobacco and cannabis smoking. Current research has largely focused on studying the effect of pure nicotine on the pathogenic activities of the cariogenic bacterium Streptococcus mutans and its partner species Candida albicans, and the effect of the more relevant vaping products of nicotine and cannabis on their interaction is currently largely unknown. This study is designed to address this knowledge gap by evaluating the action of nicotine and cannabis vape aerosols produced by ENDS on standard laboratory microorganisms and, importantly, clinical isolates from the actual adolescents and young adults who vape and those who do not use these products.

PI_NAMEs: LUX, RENATE  (contact);TRAN, NINI CHAICHANASAKUL

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acids;Address;Adolescent;Adolescent and Young Adult;Adult;aerosolized;Aerosols;Affect;age group;Behavior;Binding;Biological;Candida albicans;Cannabinoids;Cannabis;cariogenic bacteria;Cell Survival;Cellular Morphology;Centers for Disease Control and Prevention (U.S.);Chemicals;cigarette smoke;Clinical;clinical effect;clinical investigation;Clinical Research;clinically relevant;Consumption;COVID-19 pandemic;Data;Dental caries;design;Development;differential expression;early childhood;Electronic cigarette;electronic cigarette use;electronic cigarette user;Electronic Nicotine Delivery Systems;Environment;Etiology;Evaluation;Exhibits;Exposure to;extracellular;Genes;Genetic Transcription;Growth;Health;health communication;High Pressure Liquid Chromatography;High Prevalence;high school;human old age (65+);Incidence;Investigation;Knowledge;Laboratories;lonely individuals;marijuana smoke;Marijuana Smoking;marijuana use;marijuana vaping;Mental Health;Microbial Biofilms;microorganism;Middle School Student;Mouth Diseases;Nicotine;Oral health;oral pathogen;Pathogenesis;Pathogenicity;Phenotype;Physical condensation;Physiological;Play;Polymers;Population;Predisposition;Prevalence;Production;Public Health;Publishing;recruit;Reporting;Research;response;Risk;Risk Factors;Role;Streptococcus mutans;Study Subject;Surveys;synergism;Testing;Tetrahydrocannabinol;Tobacco;Tobacco smoking behavior;Tobacco use;Validation;vaper;vaping;Virulence;virulence gene;young adult;Youth

PROJECT_TITLE: Effect of aerosolized tobacco and cannabis products on Streptococcus mutans and Candida albicans interkingdom cariogenicity

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_CITY: MADISON

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE The goal of this Administrative Supplement application is to secure funding necessary to purchase a confocal microscope, which is critical for the completion of experiments detailed in NEI funded R01 (EY032543), titled “Neural Retina-Specific Bim Expression and Hyperoxia Sensitivity of the Developing Retinal Vasculature”. The confocal microscopy system will be used for high-resolution imaging of retinas from mice with different genotypes and treatments as described in the application.

PI_NAMEs: ZAITOUN, ISMAIL S (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Administrative Supplement;angiogenesis;Apoptotic;Astrocytes;BCL2 gene;Blood Vessels;Cardiovascular system;Clinical;Confocal Microscopy;Development;Embryonic Development;Endothelial Cells;experimental study;Exposure to;Eye diseases;Funding;Genotype;Goals;high resolution imaging;Hyperoxia;insight;Ischemia;Mediating;member;Microscope;Modeling;mouse model;Mus;neovascularization;Neural Retina;Neurons;Oxygen;parent project;Pericytes;Play;pre-clinical;Protein Family;Regulation;Research;Retina;retinal angiogenesis;Retinal Diseases;retinal imaging;Retinal Neovascularization;retinal neuron;Retinopathy of Prematurity;Role;Secure;System;Vascular Endothelial Growth Factors

PROJECT_TITLE: Adminstrative Suplement: Neural Retina-Specific Bim Expression and Hyperoxia Sensitivity of the Developing Retinal Vasculature


ADMINISTERING_IC: DK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Urologic Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

ORG_STATE: TX

PHR: Project Narrative The proposal aims to address the challenge of managing antibiotic-refractory recurrent urinary tract infections (rUTIs) by utilizing BactVue, a novel bacteria-specific photothermal dye developed in the Gassensmith lab. BactVue is a bacteria-selective probe that can permeate epithelial cells, bind to intracellular bacteria, and, upon brief irradiation with a laser, fluoresces to reveal the bacterial location or, with prolonged irradiation, causes photothermal heating to destroy infected tissue selectively. This proposal intends to validate the efficacy of BactVue in selectively staining diverse intracellular uropathogenic bacteria and its utility for the targeted ablation of infected bladder tissue through photothermal heating, potentially transforming the treatment paradigms for antibiotic-refractory UTI.

PI_NAMEs: DE NISCO, NICOLE JANELL;GASSENSMITH, JEREMIAH J. (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Ablation;Address;Advanced Development;amphiphilicity;Antibiotic Therapy;Antibiotics;Area;Bacteria;bacterial community;Bacterial Infections;Binding;Biopsy;Bladder;Bladder Tissue;Cauterize;cell killing;Cell membrane;Cells;Cessation of life;Chemicals;Chemistry;Chronic;Clinical;clinical application;clinical translation;Cystectomy;Cystitis;Development;Dyes;effective therapy;efficacy validation;Electrocoagulation;Enterococcus faecalis;Epithelial Cells;Epithelium;Excision;Fluorescent in Situ Hybridization;Gentamicins;Gram-Positive Bacteria;healing;Health;Heating;high risk;Human;In Vitro;in vivo;Incidence;Incontinence;Infection;Infiltration;Inflammation;innovation;Intervention;intravesical;Invaded;irradiation;Klebsiella pneumoniae;Label;Lasers;Lesion;Location;Mammalian Cell;Modeling;Mus;novel;Oral;Outcome;Outpatients;Pain;pathogenic bacteria;Patient Isolation;Patients;Penetration;Population;Procedures;Proteus mirabilis;Publishing;Recovery;Recurrence;recurrent infection;Refractory;Resolution;Ribosomal RNA;Septicemia;Stains;Surface;Testing;Time;Tissue Embedding;Tissues;tool;Tumor Debulking;Urinary tract infection;Uropathogen;Uropathogenic E. coli;Urothelium;Visual;Woman

PROJECT_TITLE: Targeted ablation of bladder-resident uropathogenic bacteria with a novel cell penetrating dye

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Genetics;Neurosciences;Pediatric;Rare Diseases;Spina Bifida;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: AUSTIN

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative  This research program is highly relevant to public health as spina bifida (SB), resulting from the defects of spinal neural tube (SNT) formation, is the second most prevalent birth defect in humans with life-long disabilities and neurological disorders. We will investigate how genetic predisposition and its interaction with environmental factors regulate human SNT formation with in vitro 3D SNT organoids and develop an SNT chip with an advanced microfluidics system to recapitulate the spatiotemporal microenvironment. The ultimate goal of this research program is to provide the scientific and technical progress toward developing novel intervention strategies for SB.

PI_NAMEs: KIM, SUNG EUN  (contact)

PROGRAM_OFFICER_NAME: TOYAMA, REIKO

PROJECT_TERMS: 3-Dimensional;Affect;Biomechanics;Biomedical Engineering;Combinatorics;Complex;Congenital Abnormality;Cues;Defect;Development;drug sensitivity;Embryo;Environmental Risk Factor;Etiology;experimental study;Exposure to;Failure;gene environment interaction;Gene Expression;Gene Expression Profile;gene interaction;Genes;Genetic;genetic association;Genetic Predisposition to Disease;Genetic study;Genotype;Goals;Human;human embryonic stem cell;human induced pluripotent stem cells;improved;In Vitro;in vitro Model;in vivo;induced pluripotent stem cell;Intervention;Knowledge;Lifelong disability;Location;Measures;Mediating;Microfluidic Microchips;microfluidic technology;Microfluidics;model organism;Modeling;Modification;Molecular Profiling;morphogens;Morphology;mouse model;Mus;Mutation;Nervous System Disorder;Neural tube;Neural Tube Defects;novel;Organoids;patient derived induced pluripotent stem cells;Pattern;personalized intervention;Phenotype;progenitor;programs;Public Health;Research;Role;screening;Skeleton;spatiotemporal;Spinal;Spinal Dysraphism;stem cells;success;System;Technology;Teratogens;Testing;Therapeutic;transcriptome sequencing;Valproic Acid

PROJECT_TITLE: Development of in vitro human spinal neural tube model to study genetic and environmental etiology of Spina Bifida.

STUDY_SECTION: CMT

STUDY_SECTION_NAME: Cellular and Molecular Technologies Study Section[CMT]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Complementary and Integrative Health;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Prevention

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE New preventive and treatment modalities are needed for persons with weakened immune systems against enteric infections. The Hang lab has recently discovered specific Enterococcus peptidoglycan hydrolases can confer protection against bacterial diarrhea illness. We therefore propose to evaluate the activity of orally available recombinant Enterococcus peptidoglycan hydrolase hydrogel formulations in mouse models of enteric infection.

PI_NAMEs: HANG, HOWARD C (contact)

PROGRAM_OFFICER_NAME: KIM, HYE-SOOK

PROJECT_TERMS: Animal Feed;Anti-Infective Agents;anti-microbial drug;Antimicrobial Resistance;Biochemistry;Caenorhabditis elegans;Cells;chemically induced colitis;Clinical;Clinical Trials;Clostridium difficile;combat;Culture Media;Data;Development;Diarrhea;diarrheal disease;Drug Delivery Systems;Drug resistance;Effectiveness;enteric infection;enteric pathogen;Enterococcus;Enterococcus faecium;enzyme model;Enzymes;Formulation;Foundations;Gastrointestinal tract structure;Genetic Engineering;Human;Hydrogels;Immune;Immune system;Immunity;improved;In Vitro;in vitro activity;in vivo;Infection;Inflammation;interest;intestinal barrier;Intestines;Laboratories;Lactobacillus;Mediating;Microbe;microbiota;Modality;Molecular;mouse model;murine colitis;N-Acetylmuramoyl-L-alanine Amidase;novel strategies;novel therapeutics;Oral;Peptidoglycan;Persons;Physicians;prebiotics;Prevention;Preventive;Probiotics;protective effect;Proteins;receptor;Recombinants;Reproducibility;Resistance;response;Role;Safety;Salmonella typhimurium;Science;Scientist;Therapeutic;tool;Translating;Work

PROJECT_TITLE: Modulation of host immunity with recombinant peptidoglycan hydrolases

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Ultrasound neuromodulation is a targeted and non-invasive approach to treating the precise regions in the brain that contribute to neurological disease. This project aims to develop a platform capable of measuring the interaction between ultrasound neuromodulation and the targeted brain regions. The platform will enable the development of non-invasive protocols for precise and effective treatment of neurological disorders using ultrasound.

PI_NAMEs: WEBB, TAYLOR D (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acoustics;Acute;Alzheimer's Disease;American;Amygdaloid structure;Anatomy;anxiety treatment;area striata;Automobile Driving;Aversive Stimulus;awake;Behavior;Brain;Brain region;Cell Nucleus;Cephalic;cerebral blood volume;Choice Behavior;Chronic;clinic ready;Clinical;clinical effect;Clinical Research;cranium;Development;Disease;early phase clinical trial;effective therapy;Electronics;Elements;Epilepsy;Excision;experimental study;flexibility;Frequencies;Fright;Future;Goals;Grain;Healthcare;Human;Image;Image-Guided Surgery;Implant;implantation;Individual;insight;Ipsilateral;Lateral Geniculate Body;Measures;Mental Depression;Mental disorders;Mental Health;Modeling;Monitor;Muscle;Nervous System Disorder;neural;neural circuit;Neural Inhibition;neuroregulation;nonhuman primate;optimal treatments;Patients;Physiologic pulse;Post-Traumatic Stress Disorders;preclinical study;Primates;Protocols documentation;Psyche structure;real time monitoring;response;Rice;Skin;skull implant;Sonication;Source;System;Technology;technology platform;Time;Tissues;treatment optimization;tumor;tumor progression;Ultrasonography;ultrasound;Uncertainty;Universities;Utah;Validation;Variant;Visual;Visual Cortex;visual stimulus;Visual System

PROJECT_TITLE: Effective Ultrasound Neuromodulation in the Awake Primate Brain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-Q (91)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Mental Illness;Racial and Ethnic Minority Health Research;Recovery Support Services;Rehabilitation;Social Determinants of Health;Substance Misuse

ORG_CITY: EAST LANSING

ORG_NAME: HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES

ORG_STATE: MI

PHR: PROJECT NARRATIVE Low-income, racial/ethnic minoritized individuals have limited access to evidence-based interventions for men- tal health, especially Black adults living in low-income areas. Peer recovery specialists, individuals in recovery from mental health and/or substance use problems, may have potential for increasing access to evidence- based interventions for Black individuals from low-resource communities, particularly when trained and super- vised in models that are acceptable and feasible in these communities. By evaluating a peer-delivered evi- dence-based behavioral intervention, and how well it could be sustained, findings may have the potential to significantly improve access to mental health treatment in traditionally underserved communities.

PI_NAMEs: FELTON, JULIA W (contact);MAGIDSON, JESSICA F

PROGRAM_OFFICER_NAME: MARRO, MARY ACRI

PROJECT_TERMS: acceptability and feasibility;Adaptive Behaviors;Address;Adoption;Adult;Area;Automobile Driving;Behavior Therapy;Behavioral;behavioral health;Black Populations;Black race;Caring;Certification;Cities;Clinic;Clinical;Clinical effectiveness;Communities;community advisory board;community based treatment;community setting;comorbidity;cost effectiveness;Data;depressive symptoms;design;Disease;disparities in morbidity;Distress;Effectiveness;effectiveness evaluation;effectiveness outcome;effectiveness/implementation trial;ethnic minority population;evidence base;Evidence based intervention;experience;functional outcomes;Funding;Goals;Health Personnel;Health Professional;health related quality of life;Health Services Accessibility;Hybrids;implementation outcomes;implementation/effectiveness;Improve Access;improved;Income;indexing;Individual;innovation;Institution;Intervention;Knowledge;Laboratories;Lived experience;Low income;Low Income Population;Major Depressive Disorder;Measures;Mediating;Mediator;Medical;Mental Depression;Mental disorders;mental function;Mental Health;Mental Health Services;mental training;Methods;Minority;Modeling;mortality;National Institute of Mental Health;novel;open label;Outcome;overdose death;Patients;peer;peer recovery;people of color;Persons;Policy Maker;poor communities;Population Heterogeneity;Poverty;Proctor framework;Psychological reinforcement;Psychosocial Assessment and Care;Quality of life;racial disparity;racial minority;racial minority population;Randomized;randomized trial;Recovery;Recreation;Research;Research Domain Criteria;Resource-limited setting;Resources;Rewards;Schedule;Service delivery model;Services;social determinants;socioeconomic disadvantage;socioeconomic disparity;socioeconomics;Specialist;stakeholder perspectives;structural health determinants;substance use;Substance Use Disorder;success;suicidal morbidity;suicide rate;Supportive care;Testing;theories;Training;treatment as usual;Treatment Effectiveness;Treatment outcome;underserved area;underserved community;Work

PROJECT_TITLE: Hybrid Effectiveness-Implementation Trial to Evaluate a Scalable, Peer-Delivered Intervention for Depression among People with Substance Use Disorder in a Certified Community Behavioral Health Clinic

STUDY_SECTION: SERV

STUDY_SECTION_NAME: Mental Health Services Study Section[SERV]


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: OKLAHOMA CITY

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE – Role of JMJD4 in Pancreatic Cancer Pancreatic tumors constitute one of the most lethal malignancies, indicating the dire need to develop novel efficacious therapies. Our research will elucidate how the JMJD4 enzyme can facilitate pancreatic tumorigenesis. This may nominate JMJD4 as a potential novel target for therapy in pancreatic cancer.

PI_NAMEs: JANKNECHT, RALF  (contact)

PROGRAM_OFFICER_NAME: CERO, CHERYL

PROJECT_TERMS: 2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine;Ablation;Affect;Agar;biological adaptation to stress;Cancer cell line;Cancer Etiology;cancer therapy;Cell Therapy;Cells;Cellular Stress;Cessation of life;Chemoresistance;Colorectal Cancer;Data;demethylation;design;Development;Disease;Down-Regulation;driving force;efficacious treatment;Enzymes;Female;Fostering;Growth;Human;Human Activities;Hydroxylation;Hypoxia;In Vitro;insight;Invaded;Knowledge;Lysine;male;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediator;Molecular;new therapeutic target;Normal Cell;novel;Oncogenic;overexpression;Oxidation-Reduction;Pancreas;pancreas development;pancreatic cancer cells;pancreatic neoplasm;pancreatic tumorigenesis;Pathway interactions;Patients;Physiological;Physiology;Play;promoter;Proteins;Research;response;Role;Seminal;side effect;small molecule inhibitor;Stress;Survival Rate;Testing;Therapeutic;Therapeutic Intervention;transcription factor;tumor;tumor growth;United States;Xenograft procedure

PROJECT_TITLE: Role of JMJD4 in Pancreatic Cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-8 (M1)]


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Pediatric;Pediatric Cancer;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Telehealth

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE The overall goal of this mixed methods study is first, to refine our current model of financial and health-related social needs navigation to integrate an established digital platform of community resources and to optimize our vocational navigation support (Aim 1). Then, we will evaluate the feasibility, including AYA uptake and engagement (Aim 2) and explore the preliminary impact on reducing financial toxicity and improving global health outcomes (Aim 3) among 80 racially, ethnically, and socioeconomically diverse AYA cancer survivors in New York City. Our intervention is patient-informed, leverages clinical and community partnerships, and thus has a high likelihood of success as well as sustainability, scalability, and overall impact.

PI_NAMEs: BEAUCHEMIN, MELISSA PARSONS (contact)

PROGRAM_OFFICER_NAME: WOLFF, JOSHUA R

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and Young Adult;Adolescent and young adult cancer patients;adolescent health outcomes;Adult;Adverse event;Age;aged;Area;Bankruptcy;Black race;cancer care;Cancer Survivor;cancer therapy;care costs;care delivery;Caregivers;Caring;Case Management;Chronic;Clinical;Communities;Community Clinical Oncology Program;community organizations;community partners;community partnership;Consent;Data;deprivation;design;Development;Diagnosis;digital;digital health;digital intervention;digital platform;Discipline of Nursing;disparity reduction;Education;effectiveness/implementation design;Enrollment;Ethnic Origin;Evaluation;Exclusion;experience;Face;Financial Hardship;financial toxicity;Focus Groups;food insecurity;Future;global health;Goals;Health;Health Care Costs;health determinants;health equity;health equity promotion;health outcome disparity;Hispanic;housing instability;Human;human centered design;Hybrids;implementation science;improved;improved outcome;Individual;Inequity;innovation;Insurance;interest;Interruption;Intervention;intervention refinement;Latino;Life;Long-Term Survivors;Malignant Neoplasms;Measures;Medical center;Medicine;Methods;Minority;Modeling;National Cancer Institute;National Institute of Nursing Research;New York City;Nonprofit Organizations;Oncology;Outcome;Participant;Patients;Pattern;peer;Persons;Pilot Projects;pilot test;poor health outcome;Population;Positioning Attribute;Poverty;programs;Psyche structure;Psychology;public health insurance;Quality of life;Race;Randomized;randomized trial;recruit;Referral and Consultation;Research;Resources;response;scale up;Science;social;social health determinants;socioeconomics;Spanish/English;Standardization;success;Survivors;Technology;telephone based;Testing;Text;Transportation;treatment as usual;Unemployment;United States;Universities;uptake;Vocation;web site

PROJECT_TITLE: Navigating Financial and Health-Related Social Needs in Adolescent and Young Adult Cancer Survivors (AYA-NAV): A Digital Intervention Pilot Study

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

PHR: PROJECT NARRATIVE Human malaria caused by Plasmodium falciparum parasites remains a devastating infectious disease marked by increasing treatment failures with frontline artemisinin combination therapies. These parasites require nutritional iron for survival, but their cellular mechanisms to acquire and distribute iron remain largely undefined. The proposed studies will test the essentiality and function of a putative iron transporter targeted to a key parasite organelle, thus elucidating a critical metal acquisition mechanism and defining a potential new therapeutic target.

PI_NAMEs: SIGALA, PAUL A (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Affinity;Antibiotics;Artemisinins;Bacteria;Biogenesis;Biology;Cells;Cessation of life;Chromosome Mapping;Combined Modality Therapy;Communicable Diseases;CRISPR/Cas technology;Critical Pathways;DNA biosynthesis;DNA Repair;doctoral student;Down-Regulation;Drug Targeting;Electron Transport;Elements;Environment;Epitopes;Erythrocytes;Evolution;Female;Genes;Genomics;Goals;Growth;Human;Impairment;innovation;inorganic phosphate;insight;Internships;Iron;Iron Chelation;isoprenoid;knock-down;Ligands;Malaria;Mammals;Mediating;Membrane;Membrane Proteins;Membrane Structure and Function;Membrane Transport Proteins;Mentors;Mentorship;Metabolic;Metabolic Pathway;Metabolism;Metals;Minority Health Research;Mitochondria;Modeling;Molecular;Native Americans;new therapeutic target;Nutritional;Nutritional Requirements;Organelles;Organism;Outcome;Parasites;Pathway interactions;Persons;Phenotype;Plasmodium;Plasmodium falciparum;programs;protein expression;Proteins;Regulation;Research;Ribosomes;Science;small molecule;summer research;System;Talents;Testing;therapeutic target;trafficking;Training;Treatment Failure;undergraduate student;Underrepresented Students;uptake;Utah;Work;Yeasts

PROJECT_TITLE: Function of a putative iron transporter in the Plasmodium apicoplast

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: RICHMOND

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Oral health is essential for the overall health well-being of adults yet oral diseases remain prevalent within this population group, particularly among adults of Central and South American ancestry. This study will examine how everyday daily life experiences shaped by upstream psychosocial factors affect oral health among adults of Central and South American ancestry. These findings will expand our understanding of how broader upstream factors contribute to oral health patterns among the adult population in the United States.

PI_NAMEs: GARCIA, DINA T (contact)

PROGRAM_OFFICER_NAME: IIDA, HIROKO

PROJECT_TERMS: access restrictions;Acculturation;Address;Adopted;Adult;Affect;Area;Attitude;Automobile Driving;Behavior;Belief;Climate;Clinical;Collaborations;Communities;community based participatory approach;Complex;craniofacial;Custom;Data;Dental;Dental Care;Dental caries;Dental Clinics;Dental Epidemiology;Dental Records;Discrimination;Disease;Disparity;disparity reduction;Economic Conditions;Elderly;Electronics;Ethnic Origin;ethnoracial;ethnoracial minority;experience;Face;Family;Foundations;Fright;Future;Generations;Goals;Health;health disparity;Health Status;Healthcare;High Prevalence;human old age (65+);Immigrant;Immigration;Individual;Inequity;innovation;Interview;Knowledge;Language;Latina;Latino;Latino Population;Latinx;Legal;Legal Status;Length;lens;Life Cycle Stages;Link;Literature;Mainstreaming;Measures;Methods;Minority Groups;Modeling;Mouth Diseases;National Health and Nutrition Examination Survey;National Institute of Dental and Craniofacial Research;Not Hispanic or Latino;nutrition;Oral;Oral health;Oral Health Impact Profile;Pain;Participant;Pathway interactions;Patient Self-Report;Periodontal Diseases;Periodontitis;Personal Satisfaction;Persons;Policies;Population;population based;Population Group;Positioning Attribute;Process;Proxy;psychosocial;Race;Recording of previous events;recruit;Research;Risk;Role;Sampling;Scientific Advances and Accomplishments;Shapes;Social Conditions;Social isolation;social structure;Source;Strategic Planning;structural determinants;Structure;Subgroup;Surveys;Target Populations;theories;Time;United States

PROJECT_TITLE: Multilevel Drivers of Oral Health: Psychosocial Stress, Health Behaviors, and Neighborhood

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (11)]


NIH_SPENDING_CATS: Neurosciences

PHR: PROJECT NARRATIVE Kainate receptors are subclass of iGluRs that mediate excitatory neurotransmission in nervous system. Their mis-regulation is implicated in neurodegenerative and neuropsychiatric disorders. The proposed research aims to elucidate the molecular mechanism of kainate receptor activation and inhibition by drug candidate molecules.

PI_NAMEs: GANGWAR, SHANTI PAL (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: Address;Agonist;antagonist;Anxiety;Architecture;Ataxia;Back;Behavior;Binding;biophysical properties;Brain;Central Nervous System;Characteristics;Complex;Cryoelectron Microscopy;Data;desensitization;design;dimer;Dissociation;drug candidate;Epilepsy;Exhibits;falls;gain of function;Genes;genetic variant;Genetic Variation;GluR5 kainate receptor;Glutamate Receptor;Glutamates;Human;inhibitor;insight;Intellectual functioning disability;interest;Intervention;Ions;Ischemia;Kainic Acid Receptors;Kinetics;Knowledge;Ligand Binding;Ligand Binding Domain;Link;Mediating;Membrane;Mental disability;Mental Retardation;Molecular;Molecular Conformation;monomer;Movement Disorders;mutant;Mutation;Nervous System;Nervous System Disorder;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;Neuropathy;neuropsychiatric disorder;neurotransmission;Neurotransmitters;novel;Outcome;Pharmacology;Phenotype;Physiology;Play;postsynaptic;Predisposition;Property;Proteins;receptor;Receptor Activation;receptor function;Receptor Inhibition;reconstruction;Recovery;Regulation;Research;Resolution;Role;Speech;Stress;Structure;Synaptic Potentials;Synaptic Transmission;targeted treatment;therapeutic development;Therapeutic Intervention;therapeutically effective;trafficking;Variant

PROJECT_TITLE: Molecular regulation of Kainate receptors

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BURLINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE

ORG_STATE: VT

PHR: Project Narrative Many bacterial diseases are caused by intracellular pathogens that deliver proteins into host cells to remodel them into a niche of survival, replication or persistence. These so-called “effector” proteins act together to promote bacterial virulence, yet how their functions are coordinated in space and time remain elusive. We found that the zoonotic bacterial pathogen Brucella abortus injects into host cells three effector proteins that form an intracellular complex. This proposal aims to characterize the structure, assembly and functions of this unique multi-effector platform and determine whether it allows coordination of effector functions during the Brucella intracellular cycle.

PI_NAMEs: CELLI, JEAN A (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Acetyltransferase;Armadillo Repeat;Bacteria;Bacterial Infections;Biochemical;Biophysics;Brucella;Brucella abortus;Cell Physiology;Cells;combinatorial;Complex;Early Endosome;Endosomes;experimental study;functional gain;Growth;GTPase-Activating Proteins;Guanosine Triphosphate Phosphohydrolases;Individual;Infection;insight;Investigation;Multiprotein Complexes;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Proliferating;protein protein interaction;Proteins;rac1 GTP-Binding Protein;Recycling;Research;retrograde transport;Role;Seminal;structural biology;Structure;Tertiary Protein Structure;Testing;Time;vesicle transport;Virulence;Zoonoses

PROJECT_TITLE: Structure and functions of a bacterial Type IV effector complex

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: ARLINGTON

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: PROJECT NARRATIVE This proposal is relevant to rural public health in the cancer care continuum. Understanding the impact of rural hospital closures on cancer outcomes will provide critical insights into their consequences on cancer care and racial/ethnic disparities. It will also inform healthcare professionals and policymakers about resource allocation and the development of tailored interventions to mitigate the negative effects of rural hospital closures on disadvantaged rural communities and populations.

PI_NAMEs: LIU, ZHAOLI  (contact)

PROGRAM_OFFICER_NAME: BAILEY, LEEANN ODETTE

PROJECT_TERMS: Address;Adherence;Affect;Area;beneficiary;Black Populations;Breast;cancer care;cancer diagnosis;cancer health disparity;Cancer Survivor;cancer therapy;cancer type;care systems;Caring;Characteristics;Colorectal;Colorectal Cancer;Continuity of Patient Care;County;Data;Data Linkages;Death Rate;Development;Diagnosis;Diagnostic;Disadvantaged;Disparity;Disparity population;ethnic disparity;ethnic minority population;Ethnic Origin;Exhibits;experience;Female;Goals;health care availability;health care disparity;health care service;Health Professional;Health Services Accessibility;Healthcare;Hispanic;Hospital Closures;Hospitals;Individual;insight;interest;Intervention;Longitudinal Studies;Lung;male;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Mediating;Mediator;Medical;Medicare;Methodology;Minority Groups;mortality;Not Hispanic or Latino;Outcome;outcome disparities;Patients;Persons;Policy Maker;Preventive service;Primary Care Physician;Prostate;Public Health;Quality of Care;Race;racial disparity;racial minority population;Research;Resource Allocation;Resources;Rural;rural cancer care;Rural Community;rural counties;Rural Hospitals;Rural Population;screening;Screening for cancer;SEER Program;Services;sociodemographics;Source;Specialist;surgical service;survivorship;Testing;trend;urban disparity;Urban Population;Vulnerable Populations

PROJECT_TITLE: Impact of Rural Hospital Closures on Cancer Outcomes and Cancer Racial Disparity among Medicare Beneficiaries

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M2)]


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: Portland

ORG_NAME: LEGACY EMANUEL HOSPITAL AND HEALTH CENTER

ORG_STATE: OR

PHR: Narrative Myopia is a global health concern due to its wide prevalence. Nearly half of the population in the world will be myopic by 2050. The molecular and cellular pathways that underlie myopia remain poorly understood. This proposal will identify novel cellular and molecular mechanisms that underlie myopia development and link them to their hallmarks at tissue level optical coherent tomography imaging. The proposal’s overarching goal is to foster and facilitate the design and development of novel treatment strategies to halt the global myopia epidemic.

PI_NAMEs: CHAUDHARY, PRIYA  (contact);EL HAMDAOUI, MUSTAPHA ;YANG, HONGLI

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: Acceleration;Adolescent;Affect;Age;Aging;American;Animals;Anterior;Asian population;Axon;Biological;Biological Assay;Bruch's basal membrane structure;Cells;Choroid;Complex;Connective Tissue;Contact Lenses;Data;design;Development;Disease;driving force;Epidemic;Euthanasia;Experimental Models;Eye;Fostering;Gene Expression;Genes;Glass;Glaucoma;global health;Goals;Grant;Health;Homeostasis;Human;Image;Immune;immune activation;immune cell infiltrate;Immunohistochemistry;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innovation;insight;Investigation;lens;Life;Link;Location;Matched Group;Matrix Metalloproteinases;Metalloproteases;Modeling;Molecular;Molecular Analysis;monocular;Morphology;Myelin;myelination;Myeloid Cells;Myopia;nano-string;neural;Neural Canal;Neurons;nonhuman primate;novel;novel marker;Optic Disk;Optical Coherence Tomography;optical imaging;Optics;Pathogenesis;Pathway interactions;Peripheral;Population;Prevalence;Process;protein expression;protein profiling;Proteins;Proteomics;Publishing;Radial;Randomized;Refractive Errors;Reporting;Retina;retinal nerve fiber layer;Risk;Risk Factors;Scanning;Signal Pathway;Stains;Stress;Stretching;Structure of retinal pigment epithelium;Testing;Thick;Tissue Inhibitor of Metalloproteinases;Tissues;tomography;treatment strategy;Tupaiidae;Vision;Visual impairment;Visualization;Work

PROJECT_TITLE: Novel correlations in cellular, molecular and structural alterations in experimental juvenile myopia

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROCHESTER

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative: The medial olivocochlear system (MOC), when activated, can both suppress and enhance cochlear function by targeting the OHC’s pivotal role in cochlear amplification. This research will elucidate the synaptic mechanisms governing MOC-mediated enhancement, and potentially identify novel pharmacological targets for preventing or ameliorating some forms of hearing loss.

PI_NAMEs: HOLT, JOSEPH CHRISTOPHER (contact)

PROGRAM_OFFICER_NAME: CYR, JANET

PROJECT_TERMS: Ablation;Acetylcholine;Acoustic Nerve;Action Potentials;Address;Adrenergic Agents;Affect;Agonist;Amplifiers;Anesthesia procedures;Animals;antagonist;arm;Auditory;Auditory Physiology;auditory stimulus;Auditory system;Axon;Brain Stem;C57BL/6 Mouse;Catecholamines;Cells;Cochlea;Complex;Data;Dependence;Development;Dopamine;ecto-nucleotidase;Electric Stimulation;Endowment;Evaluation;Exclusion;Exhibits;experimental study;Floor;Frequencies;G-Protein-Coupled Receptors;gamma-Aminobutyric Acid;Genetic;hearing impairment;Immunohistochemistry;Inner Hair Cells;insight;Interval training;Knockout Mice;Knowledge;Labyrinth;Lateral;Location;Lymphatic;Mammals;Measures;Medial;Mediating;Methodology;mouse model;Mouse Strains;Mus;Muscarinic Acetylcholine Receptor;Nature;nerve supply;Neurons;Neuropeptides;Neurotransmitters;Nicotinic Receptors;novel;Opioid;Opioid Receptor;Organ of Corti;otoacoustic emission;Outer Hair Cells;Pattern;Peripheral;peripherin;pharmacologic;postsynaptic;Potassium Channel;Preparation;Presynaptic Terminals;prevent;Process;Purinoceptor;receptor;recruit;Research;Role;Series;Shock;Signal Transduction;sound;Specific qualifier value;Stimulus;Supporting Cell;Synapses;System;Time;tool;Training;Transgenic Mice;Travel;virtual;Work

PROJECT_TITLE: Efferent-mediated Enhancement of the Cochlear Amplifier

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rehabilitation

ORG_CITY: BOSTON

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Project Narrative  Retinal degenerative diseases are the leading cause of irreversible vision loss. Retina prosthesis are invasive implantable devices designed to stimulate sensation of vision in the eyes of individuals with these significant conditions. In this application, we aim to develop an injectable optoacoustic prosthesis as a minimal invasive approach for high precision genetic-free optoacoustic stimulation with translational potential to human.

PI_NAMEs: YANG, CHEN  (contact)

PROGRAM_OFFICER_NAME: LEE, PAEK-GYU

PROJECT_TERMS: Adverse effects;Age related macular degeneration;Animal Model;Area;Biocompatible Materials;biomaterial compatibility;blind;Blindness;Brain;Chemicals;Cicatrix;clinical translation;Clinical Trials;Collaborations;Complex;Complication;Coupled;density;design;Device Designs;Devices;electric impedance;Electrodes;Esthesia;experience;Eye;Feasibility Studies;Fiber;Film;flexibility;Foundations;France;Genetic;Human;Hydrogels;Image;Implant;implantable device;improved;In Situ;in vivo;Individual;Injectable;Injections;Intervention;Label;Legal;Lighting;Magnetic Resonance Imaging;Medical;meter;Methods;minimally invasive;multi-electrode arrays;multidisciplinary;nanomaterials;Natural regeneration;neural;neural circuit;Neurodegenerative Disorders;Neurons;neuroregulation;new technology;non-genetic;Ocular Prosthesis;Operative Surgical Procedures;Patients;Pattern;Performance;Physiology;precision genetics;Prosthesis;Prosthesis Design;Research;Resolution;Retina;retina implantation;Retinal Degeneration;retinal prosthesis;retinal stimulation;Retinitis Pigmentosa;Risk;Rodent;Rodent Model;Safety;scale up;Scanning;sight restoration;solid state;subretinal injection;Surgical incisions;Technology;technology platform;Testing;tissue culture;Tissues;translational potential;ultrasound;United States;Vision

PROJECT_TITLE: Injectable Optoacoustic Retina Prostheses

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Project Narrative Surgical training is a time-intensive activity for both the trainee and teacher, furthermore, expert clinicians are unevenly distributed geographically, and face competing demands on their time for clinical and instructional work. Our proposed autonomous coaching system is a key step towards increasing accessibility and lowering the cost of effective surgical instruction by capturing expert surgical cognition and presenting it to trainees when they practice surgery. The project’s significance to public health is to accelerate the acquisition of surgeon skills, which is associated with improved patient post-operative outcomes.

PI_NAMEs: CHUA, ZONGHE  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Acceleration;Address;Adopted;Area;Attention;Augmented Reality;Automation;Benchmarking;Cadaver;candidate identification;Caring;Clinical;clinical practice;Cognition;cognitive enhancement;Complex;cost;Country;Data;Data Collection;Data Set;Dedications;design;Development;Dissection;Drops;Education;Educational process of instructing;Effectiveness;effectiveness testing;effectiveness validation;Environment;Equipment and Supplies;Evaluation;experience;Face;Family suidae;Feedback;Free Will;gaze;generative adversarial network;generative models;Geography;Goals;Healthcare Systems;high risk;Human;improved;Individual;innovation;Instruction;instructor;instrument;interest;Intuition;invention;Link;Maps;Measures;Methods;minimally invasive;Modeling;Motion;Needles;neural network;Operative Surgical Procedures;Outcome;Output;Participant;Patient-Focused Outcomes;Patients;Pattern;pedagogical content;Performance;Persons;porcine model;Postoperative Period;Productivity;programs;Public Health;Research;Research Personnel;robot assistance;Robotics;sample fixation;simulation;skill acquisition;skills;skills training;Stream;Stress;Surgeon;System;teacher;Testing;Time;tissue phantom;Training;training data;Validation;Variant;Video Recording;virtual coach;virtual reality;virtual reality simulation;virtual reality simulator;virtual surgery;Virtual System;Vision;Visual;Visual attention;visual feedback;Visual Perception;Work

PROJECT_TITLE: Autonomous Gaze Coaching for Virtual Reality Telesurgical Simulators

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Aging;Assistive Technology;Bioengineering;Brain Disorders;Clinical Research;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Parkinson's Disease;Prevention

ORG_CITY: ALBANY

ORG_NAME: ALBANY RESEARCH INSTITUTE, INC.

PHR: Project Narrative Present methods for assessing color vision (CV) are not sensitive/specific enough to detect the changes in CV caused by Parkinson’s disease (PD), or are unsuitable for people cognitive impairments and/or motor deficits (CIs/MDs) that occur during both the prodromal and clinical stages of PD. We recently demonstrated a new brain- computer interface (BCI)-based method for CV assessment and propose to test the hypothesis that this new assessment has enhanced sensitivity, specificity, and test-retest reliability for detecting color vision deficiencies (CVDs) related to PD compared to existing behavior-based assessments. If successful, our research will enable the use of CVDs as early biomarkers of PD, CV assessment as a method for monitoring PD progression, and may lead to the use of CV assessment for the early detection of CVDs caused by other neurological disorders.

PI_NAMEs: NORTON, JAMES JOHN STANLEY (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, KRISTIN HEDGEPATH

PROJECT_TERMS: Affect;Age;Alzheimer's Disease;American;Behavior;Biological Markers;brain computer interface;Classification;Clinical;clinical application;clinical diagnosis;cognitive testing;Color;color detection;Color Visions;cost;Data;Data Collection;Data Set;Deficiency Diseases;Diagnosis;Disease Progression;early detection biomarkers;Early Diagnosis;Early identification;Early treatment;Essential Tremor;Evaluation;experimental study;Eye diseases;Impaired cognition;improved;Individual;Intervention;Lewy Body Dementia;Life Expectancy;Light;Measures;Methods;Monitor;Motor;motor deficit;Movement;Multiple Sclerosis;Nervous System Disorder;Neurologic;non-motor symptom;Outcome;Parkinson Disease;Participant;Persons;predictive test;Quality of life;Race;Recording of previous events;recruit;Reporting;Research;Sensitivity and Specificity;Sensory;sex;showing emotion;Signs and Symptoms;Source;Specificity;Testing;therapy outcome;Visual evoked cortical potential

PROJECT_TITLE: Brain-computer interface (BCI)-based identification of color vision deficiencies (CVDs) related to Parkinson’s Disease (PD)

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Nutrition;Obesity;Physical Activity;Prevention

ORG_CITY: SAN DIEGO

ORG_NAME: SCINTILLON INSTITUTE FOR PHOTOBIOLOGY

PHR: Project Narrative Age-related increase in the energetic cost of physical activity in mice and age-related changes in physical activity energy expenditure in humans suggest the utility of these metrics as biomarkers of aging. We are developing a comprehensive platform for enduring thermal imaging in a controlled environment.

PI_NAMEs: TERSKIKH, ALEXEY V (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Address;Affect;Age;age difference;age related;age related changes;age-related disease;Aggressive behavior;Aging;aging biomarker;aging related;Alzheimer's Disease;Animal Behavior;Animal Model;Animals;Architecture;Behavior;behavior observation;behavior test;Behavioral;behavioral study;Biological;Body Temperature;Body Weight decreased;Caloric Restriction;Carbon Dioxide;Chronology;Circadian Rhythms;clinically relevant;Code;cohort;Computer software;Controlled Environment;cost;cost effective;Dedications;deep learning;deep learning algorithm;deep learning model;deep neural network;Dependence;Development;Devices;drug candidate;Energy Metabolism;Environment;Etiology;Exploratory Behavior;Food;Grooming;healthspan;Heterogeneity;Home;Human;Human Resources;Image;Image Analysis;implantation;improved;Individual;Intervention;Laboratories;life span;Link;Masks;Measurable;Measurement;Metabolic;Metabolism;microchip;middle age;Modality;Modeling;Monitor;Motor Activity;mouse model;Mus;novel;old mice;Pathologic;Phenotype;Physical activity;Physiological;Pruritus;Pythons;Radio;radio frequency;Research Personnel;Rodent;Running;Series;Short-Term Memory;social;Social Behavior;Stress;System;Telemetry;Temperature;Testing;Texture;Time;total energy expenditure;Toxic Environmental Substances;Transportation;Ultradian Cycle;user-friendly;Validation;volunteer

PROJECT_TITLE: Testing energy expenditures as biomarkers of aging using thermal imaging in a controlled environment

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Emerging evidence shows that bile acids regulate mucosal and systemic immunity. This proposal will examine the mechanisms by which a Lachnospiraceae-derived secondary bile acid, isoDCA, promotes mucosal homeostasis and protects against intestinal inflammation.

PI_NAMEs: NAGLER, CATHRYN R (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: absorption;Acids;Anabolism;Antigen-Presenting Cells;Antiinflammatory Effect;B-Lymphocytes;Bacteria;Bile Acids;Biological Assay;Butyrates;CD11c Antigens;cell type;Chicago;Chronic Disease;Collaborations;Colon;Data;Deoxycholic Acid;Dietary Fats;Emulsifying Agents;Engineering;Enzymes;epimerization;Epithelial Cells;Flagellin;FOXP3 gene;G-Protein-Coupled Receptors;GPBAR1 gene;gut bacteria;gut inflammation;gut microbes;gut microbiome;Homeostasis;Hydroxysteroid Dehydrogenases;Immune response;Immune system;Immunity;immunoregulation;In Situ;innovation;insight;intestinal epithelium;Intestines;Introns;Laboratories;Lamina Propria;Link;microbiome;Modeling;Mucous Membrane;Mus;mutant;novel;Prevalence;Production;Public Health;receptor;Regulatory T-Lymphocyte;response;Role;Ruminococcus;Signal Transduction;Small Intestines;Societies;System;Testing;Tryptophan;Universities;Urbanization;Volatile Fatty Acids

PROJECT_TITLE: An engineered Clostridial consortia to interrogate immune modulation by secondary bile acids


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed mixed-methods study will investigate xylazine’s growing prevalence in the illicit drug markets in the Appalachian foothills of North Carolina and investigate its epidemiological impact on consumer perceptions, behavior, and health. Knowledge gained from this study will clarify xylazine’s overall prevalence in the illicit drug market and its relative prevalence in specific drugs; identify consumers’ homegrown strategies for discerning xylazine in their drugs; and identify Drug, Set, and Setting (DSS) risk factors, psychosocial consequences, behavioral risk, and adverse health outcomes associated with xylazine exposure. Because the sharp growth in xylazine exposure among people who use drugs comprises an emerging health crisis, this study will directly inform local and national efforts for combatting harms associated with xylazine use by disseminating findings to community members and decisionmakers in real time.

PI_NAMEs: ZIBBELL, JON ERIC (contact)

PROGRAM_OFFICER_NAME: CREAMER, MELISA RAY

PROJECT_TERMS: Address;Advisory Committees;Anticonvulsants;Appalachian Region;authority;Awareness;Behavior;Behavioral;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;Collaborations;Communicable Diseases;Communities;community organizations;Consumption;County;Data;Data Collection;Development;disorder risk;drug market;drug testing;Drug usage;drug use behavior;Drug user;Environment;Epidemiologic Methods;Epidemiology;experience;Exposure to;Fentanyl;fentanyl overdose;Funding;Growth;Harm Reduction;Health;Home;Illicit Drugs;improved;injection drug use;insight;instrument;Intelligence;interest;Interview;Investigation;Knowledge;Location;Marketing;Measures;member;Methods;Modeling;Molds;Needle-Exchange Programs;North Carolina;novel;opioid epidemic;opioid mortality;Outcome;Overdose;overdose death;overdose risk;Participant;Patient Self-Report;Pattern;Perception;Persons;Pharmaceutical Preparations;Physiological;Policies;Prevalence;Principal Investigator;Psychologist;psychosocial;Public Health;Recommendation;recruit;Reporting;Research;Research Personnel;response;Risk;Risk Behaviors;Risk Factors;Sampling;Scientist;Site;Social Network;sociologist;Surveys;Testing;Time;Trust;United States National Institutes of Health;Universities;Wit;wound;Xylazine

PROJECT_TITLE: Growing Xylazine Supply in NC: A Community-Based Investigation of Exposure and Health Consequences

STUDY_SECTION: LHB

STUDY_SECTION_NAME: Lifestyle and Health Behaviors Study Section[LHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Narrative In this randomized clinical trial, we will examine the effects of African Dance and Africana Education on cognitive and brain function in older African Americans. We will be collecting a battery of cognitive, neuroimaging, psychosocial, physical function measures, and blood-based biomarkers to examine the outcomes and mechanisms of the intervention.

PI_NAMEs: ERICKSON, KIRK I (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adherence;African;African American;African American population;Age;Alzheimer's Disease;Anxiety;Area;Biological;Biological Testing;Blood Glucose;blood lipid;Blood Pressure;blood-based biomarker;Brain;brain health;brain morphology;Brain region;Caucasians;Cerebrovascular Circulation;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive performance;Communities;Control Groups;cost;Dance Therapy;Dancing;Data;Dementia;dementia risk;Education;Educational Intervention;Emotional;Enrollment;Exercise;exercise intervention;experience;Fatigue;Funding;Future;Health;Health Benefit;health disparity;High Prevalence;Hippocampus;human old age (65+);Human Resources;Hypertension;Impaired cognition;improved;Infrastructure;innovation;interest;Intervention;Loneliness;low socioeconomic status;Magnetic Resonance Imaging;Measures;Mediating;Medicare;Memory;Mental Depression;Methods;Minority Groups;Mission;Moods;neural;Neurocognitive;neuroimaging;Neuropsychology;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Outcome;Pain;Pathway interactions;Perfusion;Physical activity;Physical Function;Physiological;Pilot Projects;Prevalence;Procedures;psychosocial;Public Health;Race;racial disparity;Randomized;randomized, clinical trials;recruit;Reduce health disparities;Research;response;Rest;Risk Reduction;Sampling;statistics;Testing;Translating;Translations;United States National Institutes of Health;Vascular Diseases;waist circumference;white matter

PROJECT_TITLE: Rhythm Experience and Africana Culture Trial (REACT)


ORG_CITY: NEW ORLEANS

ORG_NAME: XAVIER UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Project Narrative Management of HIV infection is facilitated by a number of current antiretroviral therapies that effectively block HIV function. However, the probability of patient relapse increases over time, as HIV mutates and becomes resistant to approved therapeutics. This project involves the development of a new class of compounds that can target both the original and the mutated form of HIV, allowing for long-term management for HIV patients.

PI_NAMEs: WANG, GUANGDI  (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Active Sites;Address;Affinity;Animals;Anti-HIV Agents;Anti-Retroviral Agents;anti-viral efficacy;antiretroviral therapy;assay development;Binding;Binding Proteins;Binding Sites;Biological Assay;Biological Availability;Caco-2 Cells;Cells;Cellular Assay;Cessation of life;Chromatin;Chronic Disease;Clinical;Clinical Trials;Coupled;Cytochrome P450;Degradation Pathway;design;Development;Distant;DNA Integration;drug candidate;drug development;Drug Kinetics;Drug resistance;drug resistance development;drug resistant virus;Drug Screening;Drug Targeting;Enzymes;Europe;flexibility;Future;Generations;Genome;Goals;high risk;HIV;HIV drug resistance;HIV Infections;HIV Integrase;HIV resistance;HIV-1;HIV-1 integrase;in silico;indexing;Infection;inhibitor;inhibitor therapy;Integrase;interest;Lead;Life Expectancy;Measurement;Mediating;Metabolic;Modeling;Mutate;Mutation;nanomolar;Nature;North America;novel;Oncogenic;Oral;Outcome;Pathologic;Patients;Permeability;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Phosphotransferases;Plasma Proteins;Prevalence;prevent;Probability;Process;Property;Protac;Proteins;Proteolysis;Publishing;Recommendation;Regimen;relapse patients;Reporting;Research;Research Personnel;Resistance;Resistance development;resistance mutation;Site;small molecule;small molecule therapeutics;standard of care;T-Lymphocyte;Techniques;Testing;Therapeutic;Time;transmission process;ubiquitin-protein ligase;Ubiquitination;United States Food and Drug Administration;United States National Institutes of Health;Validation;viral DNA;Viral Proteins;Virus;Virus Replication

PROJECT_TITLE: Targeted Degradation of HIV Integrase as a Novel Treatment of Infection

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Pediatric;Prevention;Social Determinants of Health

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Exposure to air pollution contributes to 6.7 million deaths annually worldwide, and the majority of death and disability due to air pollution is in low and middle-income countries (LMICs). While portable air cleaners (PACs) have been demonstrated to effectively reduce particulate matter in high-income countries, their use in LMICs has been limited by several challenges. This project will study several of these challenges and seeks to demonstrate that PACs can reduce particulate matter, can remain continuously powered, and can be used consistently in an LMIC setting. This project is highly relevant to the NIH mission of reducing illness and disability and to the NIEHS strategic priorities of reducing environmental health disparities and ensuring environmental justice.

PI_NAMEs: MOSCHOVIS, PETER P (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adoption;Adult;Agriculture;Air;air cleaner;Air Pollution;Cessation of life;Characteristics;Child;cohort;Cohort Studies;community based research;cooking;Cookstove;cost;Country;Data;design;diaries;disability;Effectiveness;Electricity;Ensure;environmental health disparity;environmental justice;Environmental Risk Factor;Evaluation;experience;experimental study;Exposure to;Family;Filtration;fine particles;Focus Groups;Funding;Goals;Health;high efficiency particulate air filter;Home;Household;Income;Infant;Intervention;Intervention Trial;Location;low and middle-income countries;Measures;Methods;Mission;Modeling;National Institute of Environmental Health Sciences;Output;Particulate Matter;Perception;Persons;Pneumonia;Policy Maker;Pollution;portability;Positioning Attribute;Power Sources;prevent;Recommendation;Recording of previous events;Research;Research Infrastructure;Rural;Seasons;Series;simulation;Solar Energy;Source;Speed;Structure;Surveys;System;Testing;Time;Uganda;United States National Institutes of Health;ventilation;Vulnerable Populations;Work

PROJECT_TITLE: Optimizing air purification strategies to reduce household PM2.5 exposure in Uganda

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Clinical Research;Maternal Health;Maternal Morbidity and Mortality;Mental Health;Nutrition;Pediatric;Physical Activity;Pregnancy;Prevention;Social Determinants of Health;Women's Health Research

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative: Despite the National Institute of Health's recommendation for exclusive breastfeeding in the first 6 months for improved child health and development, challenges such as return to work, inconsistent milk supply, and postpartum stress hinder successful breastfeeding outcomes for mothers. Leveraging passive longitudinal monitoring through smartphones and smartwatches, this study aims to explore how physiological and behavioral patterns, along with self-reported factors, in the third trimester impact breastfeeding. The study's approach seeks to transform our understanding of breastfeeding outcomes, paving the way for personalized recommendations, and ultimately improving child health and development.

PI_NAMEs: SATHYANARAYANA, AARTI  (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Accounting;Address;Advocate;Affect;Area;Awareness;Behavior;Behavioral;Behavioral Sciences;Breast Feeding;Cellular Phone;Centers for Disease Control and Prevention (U.S.);Child;Child Development;Child Health;Child Welfare;Chile;Clinical;clinical practice;critical period;Data;Data Collection;design;Development;digital phenotyping;Ecological momentary assessment;Education;Exclusive Breastfeeding;Exercise;expectation;experience;Face;handheld mobile device;Health;Health Sciences;improved;Infant Health;innovative technologies;insight;Intervention;Knowledge;Life;Life Style;lifestyle factors;Maternal Health;maternal outcome;maternal wellbeing;Medical center;Mental Health;milk supply;Monitor;Moods;Mothers;novel;Outcome;Patient Self-Report;Pattern;Personal Satisfaction;personalized intervention;Physical activity;Physiological;Pilot Projects;Play;Population;Positioning Attribute;Postpartum Period;Pregnancy;pregnant;Pregnant Women;Protocols documentation;Psyche structure;Recommendation;Reporting;Research;Research Proposals;Role;Sleep;smart watch;Social support;socioeconomics;Stress;success;Techniques;Third Pregnancy Trimester;Time;tv watching;United States National Institutes of Health;wearable data;Woman;Work

PROJECT_TITLE: Enhancing Breastfeeding Outcomes through Digital Phenotyping

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Obesity;Physical Activity;Prevention

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE Long-term maintenance of regular physical activity significantly lowers risks of cancer. Emotional responses during physical activity can trigger unconscious implicit attitudes towards the behavior (e.g., favorable/ unfavorable) that contribute to the likelihood of future behavior engagement. This study will examine whether implicit attitudes towards physical activity can be experimentally manipulated by daily “emotion-based” intervention strategies and whether changes in implicit attitudes lead to changes in physical activity behavior among adults at elevated risk of cancer due to inactivity and overweight/obesity.

PI_NAMEs: DUNTON, GENEVIEVE FRIDLUND (contact)

PROGRAM_OFFICER_NAME: HALL, KARA L

PROJECT_TERMS: Accelerometer;Address;Adherence;Adult;Affect;American;Attitude;Awareness;Back;Behavior;behavior change;Behavior Therapy;Behavioral Mechanisms;Body Weight;cancer risk;Categories;Cellular Phone;Cognition;cognitive control;Cues;Data;Drowsiness;Emotional;Emotions;Evaluation;exercise intervention;experience;Exposure to;Fatigue;Feeling;Future;Goals;Guided imagery;handheld mobile device;Health;Health behavior change;Heart Rate;Implicit Association Test;improved;Individual;innovation;insight;Intervention;intervention effect;Intervention Studies;Lead;Life;Maintenance;Malignant Neoplasms;Measures;Mediating;Mediator;Medicine;Meta-Analysis;mobile computing;mortality;negative affect;Obesity;Outcome;Outcome Measure;Overweight;Pain;Persons;Physical activity;physical inactivity;positive emotional state;Process;psychologic;Randomized;Reaction Time;Recommendation;response;Science;sedentary;Stress;Thinking;Time;Translating;treatment effect;treatment strategy;Unconscious State;Variant;Visualization

PROJECT_TITLE: Using real-time data capture to examine implicit attitudes as mediators of physical activity adherence in interventions


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Injury;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Homelessness;Mental Health;Mental Illness;Pediatric;Prevention;Social Determinants of Health;Suicide;Violence Research;Youth Violence

ORG_CITY: TORRANCE

ORG_NAME: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER

PHR: PROJECT NARRATIVE Adolescents experiencing homelessness (AEH) have higher rates of suicidal behavior compared to their domiciled counterparts, especially during school breaks (i.e., summer, Fridays, and Saturdays), while their domiciled counterparts have lower rates during these periods. Although recent studies noted decreased rates of suicidal behavior among adolescents in spring 2020, coinciding with nationwide school closures as a pandemic control measure, we hypothesize increased suicidal behavior among AEH in spring 2020 based on our prior study indicating AEH face higher risk when away from school. The proposed project will investigate annual rates of suicidal behavior among AEH and domiciled adolescents from 2016 to 2022 to determine whether the pandemic has exacerbated existing disparities, as well as assess monthly trends before, during, and after the pandemic with the goal of informing tailored suicide prevention measures for AEH, especially before and during school breaks, and enhancing preparedness for potential future school closures due to pandemics.

PI_NAMEs: SAKAI-BIZMARK, RIE  (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Adolescent;Adopted;Affect;Age;age group;aged;Area;Attenuated;Behavioral Mechanisms;Calendar;Cause of Death;Child;Communities;COVID-19 pandemic;Data;Data Set;Death Records;Development;Disparity;Domiciles;Economics;effective intervention;Emergency department visit;Exclusion;Exhibits;experience;Face;Family;Friends;Future;future pandemic;Goals;high risk;high-risk adolescents;Homelessness;Hospitalization;Hospitals;Incidence;Independent Living;Individual;innovation;inpatient service;Inpatients;Link;Management Information Systems;Measures;Mental Health;Mission;National Institute of Mental Health;New York City;pandemic disease;pandemic response;Parents;Pattern;Population;Positioning Attribute;prevent;Prevention;Prevention Measures;Proxy;Public Health;Readiness;Records;Reporting;Research;Research Priority;Research Project Grants;Risk;school closure;School Enrollments;Schools;Seasons;Self-Injurious Behavior;Services;Social isolation;stem;stressor;suicidal adolescent;suicidal behavior;suicidal morbidity;Suicide;Suicide attempt;Suicide prevention;suicide rate;Teenagers;Testing;Time;trend;Vulnerable Populations;Washington;Work

PROJECT_TITLE: Suicidal Behavior among Adolescents Experiencing Homelessness in the US during the COVID-19 Pandemic

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health

PHR: Project Narrative Using a quasi-natural experiment approach with unique data, this research will contribute fundamental knowledge about the medium- and potential long-term effects of the COVID-19 pandemic and childcare services disruption on the developmental progress of vulnerable and at- risk children. Child care services may be instrumental to timely identification of developmental delays, therefore findings of the study will provide essential evidence about these impacts and the mechanisms behind them that can inform and alert health care providers and child care and early education policy makers dealing with the consequences of this crisis. Our results will also speak to the broader issue of the consequences of structural inequalities and lack of family support for our children’s developmental outcomes, and can serve as guidelines for policies and health initiatives targeted at vulnerable children and their families.

PI_NAMEs: PRADOS, MARIA JOSE  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TERMS: Address;Affect;Area;care systems;Caregivers;Child;Child Care;Child Development;cohort;Communities;COVID-19;COVID-19 incidence;COVID-19 pandemic;COVID-19 pandemic effects;COVID-19 risk;Data;Data Set;Deterioration;Development;Developmental Delay Disorders;Developmental Disabilities;developmental disease;Dimensions;distraction;early childhood;Early identification;Early Intervention;Education;Environment;Environmental Risk Factor;ethnic minority;Etiology;experience;Exposure to;Face;Family;Family Characteristics;family support;food insecurity;geographic difference;Guidelines;Health;Health Services Accessibility;Home visitation;Inequality;Inequity;Infant;infant outcome;Job loss;Knowledge;Life;Location;long term consequences of COVID-19;long term COVID-19 pandemic impacts;Low income;lower income families;maltreatment;Measures;Mental Health;Minority;Monitor;Natural experiment;Outcome;pandemic disease;pandemic impact;Parents;pediatrician;Policies;Policy Maker;Poverty;prevent;programs;Public Policy;racial minority;Reporting;Research;Risk;Role;screening;Services;Shock;Social Distance;Social Work;Socioeconomic Factors;socioeconomics;Source;Standardization;Stress;Time;Toddler;tool;tv watching;Variant;Virus;Work

PROJECT_TITLE: Investigating the impact of COVID-19 pandemic child care closures on developmental outcomes of young children in low-income families


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MACON

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: MERCER UNIVERSITY MACON

ORG_STATE: GA

PHR: Project Narrative DNA is the biomolecule in cells that carries instructions for making the proteins, lipids, and other molecules that make up living cells and tissues. In addition to the instructions carried in our DNA for making normal cellular proteins, we have many stretches of DNA in our genome that encode retrotransposons, which are similar to retroviruses, but they don’t infect other cells. A special ability of retrotransposons is that they can take copies of their DNA and insert those copies into new locations in our genome. This process can create mutations in our DNA, leading to cancer and other diseases. In addition, retrotransposon DNA, just like our DNA, makes proteins. Unfortunately, we know very little about the effects of these retrotransposon proteins in our cells, but we know that many types of diseased cells make much more of these proteins than healthy cells. Retrotransposon proteins also increase in cells as we age. The diseases associated with increased retrotransposon proteins include neurodegeneration, autoimmune disease, and others. The primary reason we know so little about retrotransposon proteins and their effects in our cells is because we lack reliable methods to study them. The lack of methods to study these proteins arises from the fact that there are so many copies of retrotransposon DNA in our genome, which makes conventional DNA editing technologies unfeasible. We propose to develop a novel method to eliminate retrotransposon proteins using molecules called “nanobodies”, which can be modified and introduced into cells to eliminate specific proteins. We can also use nanobodies to track retrotransposon proteins in cells to see where they go and what other proteins they interact with. Developing this new system will advance our ability to study and understand the effects of retrotransposon proteins on our health and how they influence aging and disease.

PI_NAMEs: COOK, PAMELA  (contact);DRUMMOND, JAMES

PROGRAM_OFFICER_NAME: SALVADOR MORALES, CAROLINA

PROJECT_TERMS: Activities of Daily Living;Affect;Affinity;Age;Aging;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Antibodies;Antigens;Ataxia Telangiectasia;autism spectrum disorder;Autoimmune Diseases;Bacteriophages;Binding;Biological;Brain;Cell Culture Techniques;Cell Extracts;Cell Line;Cell Physiology;Cells;chromatin remodeling;Chromosomal Rearrangement;Codon Nucleotides;Complementary DNA;Complex;cooking;Development;Disease;Disease Progression;DNA;Drug Industry;Embryonic Development;enzyme activity;Epilepsy;experience;experimental study;Frontotemporal Lobar Degenerations;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genome;Genomic DNA;Goals;Health;Homeostasis;Human;Human Genome;Immobilization;Immunologist;Immunoprecipitation;In Vitro;Inflammation;Instruction;Interferons;Intrabody;Kinetics;knock-down;Knock-out;knockout gene;Length;Libraries;Lipids;Location;Malignant Neoplasms;Mammalian Cell;MCF7 cell;Mediating;Methods;MicroRNAs;Modeling;Monitor;mRNA sequencing;Multienzyme Complexes;Mutation;nanobodies;Nerve Degeneration;neuropathology;novel;novel strategies;Nucleic Acids;Open Reading Frames;Parkinson Disease;Pathogenesis;Pathologic;Pathway interactions;Peptides;Phage Display;Phenotype;Physiology;Plasmids;Pregnancy;Process;protein purification;Proteins;pseudotoxoplasmosis syndrome;Qualifying;Recombinant Proteins;Recombinants;recruit;Reporting;Research Personnel;Retrotransposon;Retroviridae;Rett Syndrome;RNA;RNA Interference;Role;scaffold;Schizophrenia;small hairpin RNA;Small Interfering RNA;Somatic Cell;Spontaneous abortion;Stretching;Suggestion;System;Systemic Lupus Erythematosus;Technology;Testing;Time;Tissues;Transgenic Mice;Translations;ubiquitin-protein ligase;Ubiquitination;Up-Regulation;Vaccines;Western Blotting

PROJECT_TITLE: Development of a novel model to study the effects of LINE-1 retrotransposons in disease and normal physiology using nanobodies

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Menopause;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Women's Health Research

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: PROJECT NARRATIVE Rates of Alzheimer’s disease (AD) are higher in women and in Black and Hispanics; and identifying modifiable risk factors in this population is a priority in lowering the burden of AD. Compared to white women, Black and Hispanic women experience worse menopause symptoms, including hot flashes, sleep disturbance, and cognitive difficulties. The goal of this study is to determine whether sleep disturbance, hot flashes and sleep- wake activity are linked to memory performance in Black and Hispanic menopausal women, and therefore could represent midlife risk factors for cognitive decline and AD.

PI_NAMEs: PAGET-BLANC, ALEXANDRA  (contact)

PROJECT_TERMS: actigraphy;Address;Affect;Alzheimer's Disease;Alzheimer's disease risk;Alzheimer’s disease biomarker;Ambulatory Monitoring;Amyloid beta-Protein;Behavior assessment;Behavioral;Black race;black women;Brain;brain health;circadian;Cognition;Cognitive;cognitive ability;cognitive function;cognitive neuroscience;cognitive performance;Communities;Data;density;Devices;Disproportionately impacts women;Doctor of Philosophy;Electroencephalography;Episodic memory;Exhibits;experience;Face;Female;Frequencies;Galvanic Skin Response;Goals;Health;hippocampal subregions;Hippocampus;Hispanic;Hispanic Populations;Hispanic Women;Hormonal;Hot flushes;Impaired cognition;indexing;Individual;innovation;insight;Investigation;Knowledge;Latina;Life Cycle Stages;Link;Measures;Mediating;Mediator;Memory;Memory impairment;Memory Loss;men;Menopausal Symptom;Menopause;middle age;Midlife women;Minority Women;modifiable risk;Monitor;Names;Neurobehavioral Manifestations;Night Sweating;Outcome;Ovarian hormone;Pattern;people of color;Performance;Perimenopause;Physiological;Play;Population;Postmenopause;Prevalence;processing speed;Psyche structure;recruit;Reproducibility;Research;Rest;Risk;Risk Factors;Role;Rotation;Sampling;sex;Sleep;Sleep Architecture;Sleep Disorders;Sleep disturbances;sleep onset;symptomatic improvement;Symptoms;Testing;Training;vasomotor symptoms;verbal;Wakefulness;wearable device;White Matter Hyperintensity;White Women;wireless;Woman;Work

PROJECT_TITLE: Relationship between sleep disturbances, vasomotor symptoms, and cognitive health in Black and Latina midlife women

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE The proposed study examines resting state functional brain connectivity in infants with and without a family history of autism followed from birth to 18 months. The study will characterize the brain connectome during a period of extremely rapid development and plasticity, and test predictive models to demonstrate that the early changes in the connectome are meaningful and related to the core social features of autism. The study has great potential for improving identification of early brain-based risk factors for development of social difficulties and implementation of early interventions to support social attention and engagement in infancy and early childhood.

PI_NAMEs: CHAWARSKA, KATARZYNA  (contact);MENT, LAURA R.;SCHEINOST, DUSTIN

PROGRAM_OFFICER_NAME: GILOTTY, LISA

PROJECT_TERMS: Adopted;Affect;Age;Age Months;Algorithms;allostasis;Amygdaloid structure;Assessment tool;Attention;Autism diagnostic;autism diagnostic observation schedule;autism spectrum disorder;autistic children;Behavioral;Behavioral Symptoms;Biological Markers;Birth;Brain;brain based;brain behavior;Brain imaging;Characteristics;Child;Clinical;Complement;connectome;connectome based predictive modeling;Data;Development;Diagnosis;Dimensions;early childhood;Early identification;Early Intervention;Face;Family history of;Family member;fetal;Future;General Population;Genetic;improved;individuals with autism spectrum disorder;infancy;Infant;interest;Interview;Lesion;Link;machine learning method;Maintenance;Measures;Neonatal;neonate;Older Population;Outcome;Outcome Measure;Parents;Parietal;Participant;Pattern;Phenotype;postnatal;postnatal period;predictive modeling;Process;Property;prospective;Psychopathology;Recording of previous events;Regulation;Reporting;Rest;Risk;Risk Factors;Role;Sampling;School-Age Population;Signal Transduction;skills;social;social attachment;social attention;Social Behavior;Social Characteristics;Social Development;social engagement;Social Network;Social outcome;Standardization;support network;Symptoms;Testing;theories;Toddler;Variant;virtual;Virulence Factors;visual tracking

PROJECT_TITLE: Links between the neonatal connectome and dimensions of social development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BP-H (02)]