ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE. Mapping cellular communication within our bodies is fundamental to understanding physiology and disease. This project will contribute new tools that will enable higher resolution mapping of those communication circuits. By doing so, this project will enable the discovery of new signaling pathways for the treatment of human disease.

PI_NAMEs: LONG, JONATHAN Z (contact)

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Address;Albumins;Animal Model;animal model development;Animals;Benchmarking;Biochemical;Biocompatible Materials;Biology;Biotin;Biotinylation;Body System;Cell Compartmentation;cell type;Cells;Chemicals;Collection;Communication;Communities;Complex;Cytosol;Data;Dependovirus;Deposition;Development;Disease;Dose;Endocrine;Environment;Enzymes;Equipment and supply inventories;Event;extracellular;Fasting;Foundations;Funding Opportunities;Gene Modified;Generations;Genetic Recombination;Genetic Transcription;Goals;Growth Factor;Health;Hormones;Human;human disease;improved;In Vitro;in vivo;innovation;intercellular communication;interest;intraperitoneal;Label;Laboratories;Liver;Mammals;Maps;Measurement;Measures;Mediating;Membrane;Messenger RNA;Methodology;Methods;Molecular;mouse model;Mus;Nature;new technology;Organ;paracrine;Pathway interactions;Performance;Physiological;Physiology;Plasma;polypeptide;Population;Process;Protein Secretion;Proteins;Proteome;Proteomics;Protocols documentation;public repository;Reagent;Regulation;Research;Research Personnel;Resolution;Role;Shotguns;Signal Pathway;Specificity;Streptavidin;subcellular targeting;System;Technology;Testing;Tissues;tool;transduction efficiency;Validation;Viral;Virus Diseases

PROJECT_TITLE: A suite of conditional mouse models for secretome labeling

STUDY_SECTION: EBIT

STUDY_SECTION_NAME: Enabling Bioanalytical and Imaging Technologies Study Section[EBIT]


ADMINISTERING_IC: AR

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Brain Disorders;Headaches;Migraine;Neurosciences;Pain Research;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: FARMINGTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: DENTISTRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: CGRP inhibitors are now available for migraine prevention and treatment, so we will study the effects of chronic CGRP antagonism on bone healing. We aim to understand the cellular and molecular mechanism by which CGRP/CLR signaling can affect bone fracture healing. Understanding how CGRP/CLR sensory signaling influence fracture healing can pave the way for more targeted therapies for bone healing in the future.

PI_NAMEs: KALAJZIC, IVO  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: adrenomedullin;Affect;afferent nerve;aggrecan;antagonist;Binding;Biology;Biomechanics;bone;Bone callus;bone fracture repair;bone healing;Bone Injury;bone turnover;Calcitonin;Calcitonin Gene-Related Peptide;calcitonin receptor-like receptor;Calcitonin-Gene Related Peptide Receptor;Cell Differentiation process;Cell Lineage;Cells;Chemicals;Chondrocytes;Chondrogenesis;Chronic;Clinical;Complex;Data;Denervation;Endothelial Cells;Endothelium;Exhibits;FDA approved;Fracture;Future;Genes;Genetic Transcription;Genomics;Growth Factor;healing;Histology;Impaired healing;Impairment;improved;in vivo;in vivo evaluation;inducible Cre;inhibitor;Intervention;Lead;Ligands;Long-Term Effects;Mechanics;Mediating;Medical Care Costs;Mesenchymal;Mesenchymal Stem Cells;Migraine;migraine treatment;Modeling;Molecular;Molecular Target;Mus;nerve supply;Neuropeptides;neurotransmission;novel;Osteoblasts;Osteogenesis;Outcome;pain signal;Pathogenesis;Peptide Signal Sequences;Periosteal Cell;Periosteum;Pharmaceutical Preparations;Phenotype;Population;Positioning Attribute;Prevention;Preventive treatment;Process;promoter;Proteins;Quality of life;RAMP1;RAMP2;RAMP3;receptor;Receptor Signaling;Regulation;response;response to injury;Risk;Role;Sensory;Sensory Receptors;Signal Transduction;Site;stem cell expansion;stem cell proliferation;stem cells;targeted treatment;Testing;Therapeutic;Tissues;tomography;translational approach;Undifferentiated;Vascularization

PROJECT_TITLE: CGRP-CLR mediated regulation of bone healing

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: MINNEAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Relevance to Public Health Our goal is to develop an online, flow-through, affinity assay that can continuously monitor the efflux of biochemical messengers from dynamically changing biological systems in real time. Our premise is that microfluidic integration of a perfusion chamber, online mixing of affinity reagents and continuous micro free flow electrophoresis (µFFE) separations will directly address limitations that have prevented the development of time responsive affinity-based assays to date. Continuous affinity µFFE assays will enable researchers to study how biochemical messenger systems (i.e. neurotransmission, energy regulation and immune response) change over time or respond to external stimuli.

PI_NAMEs: BOWSER, MICHAEL T (contact)

PROGRAM_OFFICER_NAME: ASLAN, KADIR

PROJECT_TERMS: addiction;Address;Adipocytes;Adsorption;Affinity;affinity labeling;Antibodies;aptamer;Area;Benchmarking;Binding;Biochemical;Biological;Biological Assay;Biological Markers;Biological Models;biological systems;Biology;Biomedical Research;cancer diagnosis;Cell Culture Techniques;Cell model;Cells;Complex;design;detection limit;Development;Electrophoresis;Elements;Enzyme-Linked Immunosorbent Assay;Exhibits;Exposure to;flexibility;Goals;Home;Immune response;improved;In Vitro;Individual;Inflammation;innovation;lateral flow assay;Leptin;Ligands;mast cell;Measurement;Measures;Microfluidics;Modeling;Modernization;Monitor;Nature;Neurons;neuropeptide Y;neurotransmission;Obesity;Oligonucleotides;Optics;Pathogen detection;Performance;Perfusion;Play;Pregnancy Tests;prevent;Public Health;Reagent;Regulation;Reproducibility;Research;Research Personnel;response;Role;sensor;Signal Transduction;Stimulus;Surface;System;Time;TNF gene

PROJECT_TITLE: Online Affinity Micro Free Flow Electrophoresis Assays for Continuous Monitoring of Biochemical Messengers


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Eukaryotic circadian clocks impact nearly every aspect of physiology behavior. Their dysfunction contributes to cancer, as well as to mental illness (e.g., depression) and to metabolic diseases (e.g., diabetes). While we know a great deal about the details of molecular timekeeping within pacemaker cells, we know relatively little about how clock information is used. Circadian output generates a series of signals representing phase markers, according to which diverse downstream tissues and circuits bias their daily temporal activities. We will study the generation of circadian phase in Drosophila at the levels of behavior, neurophysiology, neuroendocrinology and intracellular signaling pathways. The detailed mechanisms thus revealed will help define how clock information underlies normal physiology and also pathophysiology.

PI_NAMEs: TAGHERT, PAUL H (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Behavior;Biological Models;Brain;brain control;Cell Communication;Cells;circadian;circadian pacemaker;Dedications;Diabetes Mellitus;Drosophila genus;fly;Functional disorder;Generations;Goals;Hormones;Laboratory Study;Malignant Neoplasms;Mental Depression;Mental disorders;Metabolic Diseases;Modeling;Molecular;molecular clock;neural circuit;Neuroendocrinology;neuromechanism;Neurons;Neuropeptides;neurophysiology;nodal myocyte;Output;Pacemakers;Periodicity;Phase;Physiology;programs;Research;Series;Signal Pathway;Signal Transduction;Sleep;Stereotyping;System;Temperature;Testing;Time;Tissues;transmission process;Work

PROJECT_TITLE: The Generation of Multi-Phasic Circadian Output


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Digestive Diseases;Liver Disease;Lymphatic Research

ORG_CITY: CHICAGO

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Dysfunctions of the immune system of the pancreas are involved in major pancreatic diseases such as pancreatic cancers and diabetes. Here we propose novel mechanisms of disease due to the crosstalk of pancreas with intestinal and hepatic immunity, mediated by the anatomical co-drainage into lymph nodes. Lymph node sharing with gut and liver exposes the pancreatic immune system to a new, previously unsuspected range of infectious and toxic challenges.

PI_NAMEs: ESTERHAZY, DARIA  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: adaptive immunity;Address;Affect;Anatomy;Antigen Presentation;Antigens;Attention;Autoimmune Diabetes;Automobile Driving;autoreactive T cell;autoreactivity;Back;Beta Cell;Biotin;Biotinylation;CD8-Positive T-Lymphocytes;Cells;cellular targeting;Clone Cells;Cre driver;cytotoxic;Cytotoxic T-Lymphocytes;Dendritic Cells;Development;Diabetes Mellitus;Diet;Digestive System Disorders;Disease;Disease Progression;Drainage procedure;draining lymph node;Duodenum;enteric infection;Environment;Enzymes;Evolution;Excision;Exhibits;Exocrine pancreas;Exposure to;Failure;Flow Cytometry;Functional disorder;gastrointestinal system;Gene Expression Profile;Genetic Transcription;Glucose;Goals;Hepatic;Homeostasis;Homing;Hormone secretion;Immune;Immune response;Immune system;Immune System Diseases;Immune Targeting;Immunity;immunological status;Immunologics;imprint;Infection;Inflammatory;Injury;insight;Insulin;Insulin-Dependent Diabetes Mellitus;Intestines;Islets of Langerhans;Life;Ligase;Liver;Liver Extract;Location;Lymph;Lymph Node Drainage;lymph nodes;lymphoid organ;macromolecule;Malignant neoplasm of pancreas;man;Mediating;Methods;Modeling;Monitor;Mus;Nature;novel;Nutrient;Organ;Outcome;Output;Pancreas;Pancreatic Diseases;Pancreatic Endocrine Secretion;Pancreatic Exocrine Secretion;Pancreatitis;Phenotype;polarized cell;Positive Lymph Node;Predisposition;prevent;Proteins;Reaction;Regulation;Research;response;Route;Shapes;Site;Source;Structure of beta Cell of islet;System;T cell response;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Tissues;Tomatoes;Toxin;uptake;virtual

PROJECT_TITLE: Immune crosstalk through shared LN drainage in the digestive system

STUDY_SECTION: DHMI

STUDY_SECTION_NAME: Digestive System Host Defense, Microbial Interactions and Immune and Inflammatory Disease Study Section[DHMI]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: The nervous system has the remarkable ability to sustain its function over lifetime of an organism. The goals of this research program are to advance our knowledge of how axons and synapses are formed and maintained, and the proposed experiments will identify new mechanisms underlying dynamic cellular processes that ensure function of neural circuits. The findings will offer fundamental insights into how genetic mutations and environmental insults cause dys-regulation of neural circuits, leading to neurological disorders.

PI_NAMEs: JIN, YISHI  (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Adolescent;Adult;Animal Model;Animals;Axon;axon injury;axon regeneration;biological adaptation to stress;Brain;Caenorhabditis elegans;Calcium;Cell Physiology;Coupled;Development;Dissection;DNA Sequence Alteration;Ensure;Event;experimental study;Functional disorder;gene discovery;Genetic Models;Genetic Screening;Goals;Growth;holistic approach;Homologous Gene;Human;in vivo evaluation;in vivo imaging;innovative technologies;insight;interest;Knowledge;Maintenance;Membrane;molecular dynamics;Molecular Genetics;Motor;Mus;Nerve Degeneration;Nervous System;Nervous System Disorder;neural circuit;Neurons;Neurophysiology - biologic function;Organelles;Organism;Pathologic Processes;Pathway interactions;Pattern;Phase;Physiological;Play;Process;programs;Property;Proteins;regeneration model;Repression;Research;Resolution;Role;Signal Transduction;single-cell RNA sequencing;Stereotyping;Subcellular structure;Synapses;synaptogenesis;Transcriptional Regulation;Visualization

PROJECT_TITLE: Molecular genetics of axon and synapse development and maintenance


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: SANTA MONICA

ORG_NAME: RAND CORPORATION

PHR: PROJECT NARRATIVE The indirect impacts of disasters—morbidity and mortality due to compromised conditions such as food security and clean water—are typically not included in estimates of disaster deaths. Child health is particularly sensitive to such compromised conditions and understanding the indirect burden of disasters on child health is central for designing mitigation and adaptation strategies. This project aims to estimate the indirect child mortality burden from floods and severe storms around the world.

PI_NAMEs: WAGNER, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Affect;Africa;antenatal;Area;Asia;Behavior;Birth;Birth Weight;Catalogs;Cells;Cessation of life;Child;Child Health;Child Mortality;Classification;climate change;climate disaster;climate impact;Conflict (Psychology);contaminated water;Country;Data;Data Analyses;Data Set;Data Sources;Databases;Demographic and Health Surveys;design;Disasters;econometrics;Epidemiology;Event;Exposure to;extreme storms;extreme weather;fighting;Floods;Food Contamination;food insecurity;food security;Foundations;Frequencies;Geography;global health;Goals;Health;health data;health record;health service use;Health system;high risk;Human;Hurricane;Imagery;improved;Income;Infant;Infant Mortality;Infrastructure;insight;Latin America;Life;Link;Location;low and middle-income countries;Malnutrition;Measurement;Measures;Methods;Morbidity - disease rate;mortality;Natural Disasters;neglect;Outcome;Policies;population survey;Postnatal Care;programs;Puerto Rico;Qualifying;remote sensing;Research Personnel;resilience;Resources;Risk;Risk Reduction;Sanitation;Services;Shock;Testing;Vaccination;Visit;Water;Work

PROJECT_TITLE: The Impact of Natural Disasters on Child Health

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: LOS ANGELES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Members of the Black community are at higher risk for cognitive impairment and Alzheimer’s disease. This project proposes to investigate several risk factors that contribute to cognitive impairment and Alzheimer’s disease, including social, neuroimaging, and genetic factors. Findings from this study may contribute to our understanding of contributors to cognitive decline, which has the potential to inform risk of future impairment and prevention for Black individuals.

PI_NAMEs: DETERS, KACIE  (contact)

PROGRAM_OFFICER_NAME: BENSON, RICHARD T

PROJECT_TERMS: Admixture;Affect;African;African American;African ancestry;Age;Aging;Alzheimer's Disease;Alzheimer's disease risk;Apolipoprotein E;apolipoprotein E-4;Area;Biological;biological heterogeneity;Biological Markers;Biology;Birth;Black American;Black Populations;Black race;Blood Vessels;Brain;brain health;Brain region;childhood adversity;Clinical;Cognition;Cognitive;Cognitive aging;cognitive function;cohort;Communities;community engagement;Competence;County;Data;Dementia;Disease;disparity reduction;Education;Enrollment;ethnic disparity;European ancestry;experience;Fathers;Future;Genes;Genetic;genetic risk factor;Goals;health disparity;Heterogeneity;high risk;Impaired cognition;Impairment;Income;Individual;Knowledge;Life;Life Cycle Stages;life span;Location;Los Angeles;Magnetic Resonance Imaging;Measures;Mediating;member;Memory;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;mild cognitive impairment;Minority;Mothers;multidisciplinary;neighborhood disadvantage;Nerve Degeneration;neural correlate;neurocognitive test;neuroimaging;neuroimaging marker;Neuropsychological Tests;Neuropsychology;non-demented;Not Hispanic or Latino;Participant;Pathologic;perceived discrimination;Population;Population Heterogeneity;Populations at Risk;Positioning Attribute;prevent;Prevention;Race;racial difference;racial disparity;racial population;Research;Research Personnel;research study;Risk;Risk Factors;risk prediction;Science;skills;social;social disparities;social factors;Socioeconomic Status;Symptoms;Testing;tool;Training;Training Activity;Variant;White Matter Hyperintensity

PROJECT_TITLE: The Impact of Social, Genetic and Neuroimaging Factors on Cognitive Functioning in the Black Community


ADMINISTERING_IC: CA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: PROJECT NARRATIVE Women at high risk for breast cancer can decide to supplement breast cancer screening with MRI, but lack of awareness and access may prevent high-risk Black and Latina women from making an informed decision about breast MRI. The proposed study will develop and test a multilevel intervention to support informed decision- making about breast MRI among high-risk Black and Latina women. If demonstrated to increase informed deci- sions, this approach can be translated to any new preference-sensitive, risk-based cancer screening modality.

PI_NAMEs: CONLEY, CLAIRE C (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Address;Age;American Cancer Society;American College of Radiology;Awareness;Behavioral;Biopsy;Black race;black women;Breast;Breast Cancer Detection;Breast Cancer Risk Assessment Tool;Breast Cancer Risk Factor;Breast Magnetic Resonance Imaging;Cancer Burden;cancer diagnosis;Cancer Etiology;cancer risk;Capital;career;Caring;Cessation of life;Clinic;Clinical;Communities;community advisory board;Community Clinical Oncology Program;community engaged research;community setting;Complement;Comprehensive Cancer Center;Conflict (Psychology);cost;cultural values;Data;Decision Aid;Decision Making;Development;Diagnosis;Disparity;District of Columbia;Early identification;Effectiveness of Interventions;effectiveness testing;Environment;Epidemiologist;experience;Future;Goals;Guidelines;high risk;High Risk Woman;Individual;International;Intervention;intervention effect;Interview;K-Series Research Career Programs;Knowledge;Latina;lifetime risk;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammographic screening;Mammography;Medical;Mentors;Mentorship;Modality;National Breast and Cervical Cancer Early Detection Program;National Comprehensive Cancer Network;National Institute on Minority Health and Health Disparities;Not Hispanic or Latino;Nurse Practitioners;Oncologist;Participant;patient level intervention;patient navigation;patient navigator;Patient Preferences;Patient-Centered Care;Patients;Persons;Population;Population Heterogeneity;Positioning Attribute;post intervention;preference;prevent;primary outcome;programs;Protocols documentation;Race;Randomized;randomized trial;Recommendation;Research;Research Support;Risk;Risk Assessment;risk prediction model;satisfaction;Scientist;screening;Screening for cancer;screening guidelines;secondary outcome;Site;skills;System;Testing;Training;Training Programs;Translating;treatment as usual;United States Preventative Services Task Force;White Women;Woman;Work

PROJECT_TITLE: The FYI on MRI: A Multilevel Decision Support Intervention for Screening Breast MRI

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ANN ARBOR

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Adolescence is a vulnerable time period when insufficient and mistimed sleep may affect cardiometabolic risk factors including adiposity, high blood pressure, and insulin resistance. To understand which aspects of sleep to intervene on, there is an urgent need to disentangle the independent contributions of short sleep duration and delayed sleep timing (proxy for circadian rhythm misalignment) to cardiometabolic risk. Examining the epigenetic pathways that link sleep duration and timing with prospective cardiometabolic risk provides a novel way to distinguish these relationships and to gain mechanistic insights.

PI_NAMEs: JANSEN, ERICA CHRISTINE (contact)

PROGRAM_OFFICER_NAME: PRICE, CANDICE

PROJECT_TERMS: Achievement;actigraphy;Adolescence;Adolescent;Affect;ARNTL gene;Award;Behavioral;Biological;Biological Markers;Blood Pressure;Candidate Disease Gene;Cardiometabolic Disease;cardiometabolic risk;cardiometabolism;career;Characteristics;Chronic;circadian;circadian biology;Circadian desynchrony;Circadian gene expression;Circadian Rhythms;Cities;Clinical;cohort;Cohort Studies;Complex;Coupled;CpG dinucleotide;Cross-Sectional Studies;Data;design;Development;DNA Methylation;DNA Sequence;Environment;Epidemiologist;epidemiology study;epigenetic marker;Epigenetic Process;epigenome;experience;flexibility;follow-up;Funding;Future;Gene Expression;Genes;Goals;Grant;Health;Heritability;High Prevalence;Hypertension;improved;Inadequate Sleep Hygiene;insight;Insulin Resistance;Intervention;Investigation;Knowledge;Laboratories;Lead;Leadership;Leukocytes;life span;Link;Lipids;Measurement;Measures;media use;Mentors;Mentorship;Metabolic;Metabolic Diseases;methyl group;Methylation;Mexico;Michigan;Modification;Molecular;novel;nutrition;Nutritional;Obesity;Observational Study;Outcome;Participant;Pathway interactions;Play;Population;professor;prospective;Proxy;Puberty;puberty transition;Public Health;Public Health Schools;Research;Research Assistant;Research Design;Research Infrastructure;Resources;Risk;Risk Factors;Role;RORA gene;Schedule;Schools;skills;Sleep;Sleep Deprivation;Sleep disturbances;sleep pattern;Statistical Data Interpretation;Testing;therapy design;Time;Training;United States National Institutes of Health;Universities

PROJECT_TITLE: Sleep and Circadian Rhythms in Adolescence: Epigenetic Pathways of Cardiometabolic Risk

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(JA)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;HIV/AIDS;Nutrition;Physical Activity;Prevention;Sarcopenia

ORG_CITY: SEATTLE

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative Non-pharmacological strategies to increase the healthspan and physical functioning of PWH are urgently needed. Our study examines how two promising strategies, habitual physical activity and dietary intake, are associated with sarcopenia in a population at high risk for developing this debilitating musculoskeletal disease. These strategies can be incorporated into ongoing health promotion initiatives in clinics nationwide to help PWH age well.

PI_NAMEs: OLIVEIRA, VITOR  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: Acceleration;Address;Age;Age Years;age-related disease;aged;Aging;aging process;Alcohol consumption;antiretroviral therapy;Anxiety;Behavior;biobehavior;Biological;Characteristics;Clinic;Clinical;clinically relevant;cohort;comorbidity;Country;Data;Development;Diet;Dietary intake;Dietary Intervention;disability;Disease;Drug usage;Dual-Energy X-Ray Absorptiometry;Economic Burden;Elderly;exercise intervention;experience;falls;frailty;Future;General Population;Goals;Health Care Costs;Health Promotion;healthspan;high risk;HIV;HIV Infections;human old age (65+);immunosenescence;Intervention;Intervention Studies;Knowledge;lean body mass;Length;Length of Stay;Life Expectancy;Life Style;lifestyle factors;Literature;Maintenance;Malnutrition;medication compliance;Mental Depression;Modeling;modifiable lifestyle factors;Morbidity - disease rate;mortality;muscle form;Muscle function;Muscular Atrophy;Musculoskeletal Diseases;normal aging;novel;Observational Study;older adult;Older Population;patient oriented;Persons;Pharmacological Treatment;Physical activity;Physical Function;physical inactivity;Physiological;Play;Population;Positioning Attribute;Prevalence;prevent;primary outcome;reduced muscle mass;reduced muscle strength;Research Priority;response;Risk Factors;Role;Sampling;sarcopenia;Scanning;Science;sedentary lifestyle;Site;Smoking;social factors;Stimulus;Symptom Burden;Symptoms;System;therapy adverse effect;Time;Viral;Woman

PROJECT_TITLE: The Influence of Habitual Physical Activity and Diet in the Development of Sarcopenia Among Older Adults With HIV

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Genetics;Immunization;Infectious Diseases;Lyme Disease;Prevention;Tickborne Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: MORGANTOWN

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: Project Narrative / Public Health Statement The proposed research is relevant to public health because Lyme disease, an infection caused by bacteria from the genus Borrelia, is endemic in the US and continues to spread. The objective of this project is to develop a vaccine against Borrelia species by combining peptides based on outer-membrane proteins expressed in various phases of B. burgdorferi infectious cycle with novel adjuvants. Therefore, this project is relevant to the part of NIH’s mission regarding enhancing health, lengthening life, and reducing illness.

PI_NAMEs: BARBIER, MARIETTE  (contact)

PROGRAM_OFFICER_NAME: BOWDEN, NADINE

PROJECT_TERMS: Address;Adjuvant;Antibodies;antigen test;Antigens;Area;Arthritis;arthropod-borne;B-Lymphocytes;Bacteria;Bacterial Antigens;Bacterial Genes;Bacterial Infections;Bioinformatics;Biology;Blood Circulation;Borrelia;Borrelia burgdorferi;Carditis;Carrier Proteins;Cell surface;Charon;Clinical Trials;cross reactivity;Data;design;Development;Disease;disorder prevention;efficacy evaluation;Encephalomyelitis;enzootic;Europe;experience;extracellular;Gene Expression;Gene Expression Profiling;Genes;Genetic;Goals;Health;Human;IL17 gene;Immune response;Immunization;immunogenic;immunogenicity;in vivo;Infection;Infection prevention;innovation;insight;Interferon Type II;Interleukin-6;Invaded;Knowledge;Laboratories;Life;Lyme Disease;Lyme Disease Vaccines;Mammals;Measures;Membrane;Membrane Proteins;Memory;Memory B-Lymphocyte;Meningitis;Methodology;Mission;mortality;mouse model;Mus;Myalgia;neutralizing antibody;next generation;novel;Nutrient;Organism;OspA protein;OspC protein;Outcome Study;pathogen;pathogenic bacteria;peptide based vaccine;Peptide Synthesis;peptide vaccination;Peptide Vaccines;Peptides;Phase;pre-clinical;Pre-Clinical Model;Prevention;Production;Protein Region;Proteins;Pseudomonas aeruginosa;Public Health;receptor;Reporter;Research;response;side effect;Smallpox;Structure of germinal center of lymph node;System;T cell response;T-Lymphocyte;Testing;Tick-Borne Diseases;tick-borne pathogen;Ticks;Toxin;transcriptome sequencing;United States National Institutes of Health;Vaccination;Vaccine Antigen;Vaccine Design;vaccine development;vaccine efficacy;vaccine evaluation;vaccine formulation;Vaccines;VDAC1 gene;vector;vector tick;Work

PROJECT_TITLE: Peptide-vaccine development against Lyme disease


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: DURHAM

ORG_NAME: RAMONA OPTICS, INC.

ORG_STATE: NC

PHR: Brain organoids are an increasingly popular platform for neuroscientific research, yet their macroscopic size (1-3 mm) prevents current high-content optical microscopes from offering an effective means to rapidly image large specimen collections for longitudinal assessment. In this project, Ramona Optics and the Stein Lab at the University of North Carolina at Chapel Hill will develop and test a parallelized, 96-camera 3D microscope and associated software to rapidly capture (< 10 sec.) the 3D morphology and volume of in vitro brain organoids within full 96 well plates. This new technology aims to drive efficiency and novel bioassay development by delivering 3D volume, surface area and morphology measurements that correlate with current standards by >95% while maintaining a 100X speed-up for experimental workflow.

PI_NAMEs: HARFOUCHE, MARK  (contact)

PROGRAM_OFFICER_NAME: ANDERSON, PAIGE MARIE

PROJECT_TERMS: 3-Dimensional;Acceleration;Agar;Area;autism spectrum disorder;Biological Assay;biological research;Brain;Cell Survival;Cells;Cerebrum;Clinical;Collaborations;Complex;Computer software;cost;Data;Development;Diameter;digital imaging;Disease;disease model;drug development;experimental study;Feedback;Fluorescence;Foundations;Geometry;Goals;Health;health assessment;high risk;Hour;human induced pluripotent stem cells;Image;Image Analysis;imaging modality;imaging platform;imaging system;Imaging technology;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;insight;Laboratory culture;Lateral;lens;Libraries;Light;Maintenance;Maps;Measurement;Measures;meter;Methods;Microscope;microscopic imaging;Microscopy;Microspheres;migration;Modeling;Morphology;Motility;neural;neurodevelopment;new technology;North Carolina;novel;Optics;Organoids;parallelization;Performance;Phase;prevent;Process;Research;research and development;Research Personnel;Resolution;sample collection;Sampling;Scanning;screening;sensor;Shapes;Slice;software development;spatiotemporal;Specimen;Speed;statistics;Structure;Surface;System;Testing;Three-Dimensional Imaging;Time;Tissues;two-dimensional;Universities;Update;Video Recording

PROJECT_TITLE: A parallelized imaging platform for accurate and efficient long-term assessment of brain organoid development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-G (13)]


ORG_CITY: Palo Alto

ORG_NAME: HALO BIOSCIENCES, INC.

PHR: PROJECT NARRATIVE Group 3 pulmonary hypertension with associated interstitial lung disease is a devastating condition with a single therapeutic option. Cutting-edge research has identified a pharmacologic inhibitor of hyaluronan production which dramatically improves outcomes in pre-clinical disease models. This project will deliver a proprietary formulation of this inhibitor, ready for clinical development as a first-in-class disease-modifying agent.

PI_NAMEs: PALADINI, RUDY  (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: 4-methylumbelliferone;Affect;Air;analytical method;angiogenesis;Animal Model;Applications Grants;Biological Assay;Biological Availability;Biological Sciences;Bleomycin;Blood Vessels;Canis familiaris;Cells;Classification;Clinical;Clinical assessments;clinical development;Clinical Research;Clinical Trials;Cyclic GMP;Deposition;Development;Disease;disease model;Disease Progression;dosage;Dose;Drug Kinetics;Ensure;Enzyme-Linked Immunosorbent Assay;Extracellular Matrix;FDA approved;Fibrosis;Formulation;Glycosaminoglycans;Human;human mortality;Hyaluronan;improved;improved outcome;In Vitro;Individual;Infiltration;Inflammation;Inflammatory;Inhalation;inhibitor;Interstitial Lung Diseases;Legal patent;Life Expectancy;Lung;Lung Diseases;manufacture;Mesenchymal;Metabolism;method development;Modeling;Molecular Conformation;Monocrotaline;mortality;mouse model;novel;novel therapeutics;Oral;overexpression;Pathogenesis;Pathway interactions;patient population;patient variability;Patients;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;pharmacologic;Pharmacology;Pharmacotherapy;Phase;Phase II Clinical Trials;phase II trial;pre-clinical;preclinical efficacy;preclinical study;Process;Production;programs;Property;pulmonary arterial hypertension;Pulmonary Fibrosis;Pulmonary Hypertension;Rattus;Reporting;Research;response;Role;Sampling;Serum;Severities;Shortness of Breath;small molecule inhibitor;Sputum;Symptoms;tablet formulation;Tablets;Technology;Therapeutic;Tissues;Toxicology;treatment group;Validation;Vascular remodeling;Vision;Walking;Work

PROJECT_TITLE: Development of a Novel Hyaluronan Inhibitor for the Treatment of Group 3 Pulmonary Hypertension (PH)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Biotechnology;Immunization;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAN DIEGO

ORG_NAME: VERSAPEUTICS INC

PHR: NARRATIVE  We are developing a novel antibody-based therapy that we hypothesize will provide significant functional benefits to humans with acute and chronic spinal cord injuries.  In this project, we will conduct GLP-Toxicity study in non-human primates through continuous intrathecal drug infusion for 28 days, with 28 days recovery.

PI_NAMEs: SUN, MIAO  (contact)

PROGRAM_OFFICER_NAME: CAPORELLO, EMILY LAURA

PROJECT_TERMS: Acute;Adult;Affect;Affinity;Age;Agreement;American;analytical method;Anatomy;Animal Testing;Animals;Antibodies;Antibody Therapy;Applications Grants;Autopsy;Axon;axon growth;axon guidance;axon injury;axon regeneration;Behavior;Binding;Biological Response Modifier Therapy;Blood;blood-brain barrier penetration;Brain;Bypass;California;Cardiovascular system;cell bank;Cell Line;Chemicals;Chronic;Clinic;Clinical Pathology;Collaborations;Communities;cost;Country;cross reactivity;Cyclic GMP;Data;Development;Dose;drug candidate;Drug Delivery Systems;Embryo;Engineering;Epitopes;Evaluation;FDA approved;Funding;Gender;Grant;Growth;Histopathology;Human;human tissue;humanized antibody;humanized monoclonal antibodies;immunogenicity;Implantable Pump;improved;In Vitro;Individual;individual patient;Infusion procedures;Injections;Injury;Intravenous Bolus;intravenous injection;Laboratories;Lead;Legal patent;Lesion;Licensing;Life;life time cost;Living Costs;Long-Term Care;Macaca fascicularis;manufacture;manufacturing process;Measurement;Medical;Methods;Mission;Monoclonal Antibodies;Mus;National Institute of Neurological Disorders and Stroke;neural circuit;Neurons;nonhuman primate;novel;novel therapeutics;Obstruction;Osmosis;Pathway interactions;Patients;Penetration;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phase;pre-clinical;pre-Investigational New Drug meeting;preclinical development;Preclinical Drug Development;preclinical safety;preclinical study;prevent;Process;professor;Pump;Quadriplegia;Rattus;receptor;Recommendation;Recovery;Recovery of Function;regenerative;regenerative growth;Research;Respiratory System;response;Risk;Rodent;Safety;Saline;Sampling;scale up;Serum;Site;Small Business Innovation Research Grant;Spinal Cord;Spinal cord injury;Spinal cord injury patients;stable cell line;Testing;Therapeutic;Therapeutic Monoclonal Antibodies;Time;Tissues;Toxic effect;Toxicokinetics;Toxicology;United States;Universities;Urine;Variant;Veterans;Vial device;Wnt proteins;Work;Writing

PROJECT_TITLE: Preclinical Toxicology Study of Intrathecal VersaMab-101 for spinal cord injury treatment

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (14)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: RICHMOND

ORG_NAME: MOSAIC ENGINEERING LLC

PHR: PROJECT NARRATIVE Given the enormous cost of bringing new drugs to market, and the many challenges associated with evaluating drug candidates using in vitro and animal models, there is much interest in leveraging stem cells to produce organoid models of various human organ systems for drug screening. A key component of this effort is mimicking the mass transport and microenvironmental properties of natural tissues and capillaries. This study will prototype and validate a versatile, programmable microfluidic organ-on-chip bioreactor platform for perfusion culture and drug screening with vascularized cardiac organoids, leveraging a low cost electronic automation manifold and SBS-format injection-molded microfluidic consumables.

PI_NAMEs: MYERS, FRANK  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Animal Testing;Architecture;Automation;Biological Assay;Bioreactors;Biotechnology;Blood capillaries;Blood flow;Body System;Brain;Cardiac;Cardiovascular system;Catalogs;CCL4 gene;Cell Culture Techniques;Cell Therapy;Cells;Cellular biology;chromatin immunoprecipitation;Collaborations;Communities;Computer software;Congresses;Consumption;cost;design;Development;digital;Dose;Drug Approval;drug candidate;drug discovery;drug efficacy;Drug Screening;Drug toxicity;Electronics;Eligibility Determination;Ensure;Ethics;experience;Failure;Friends;Goals;Growth Factor;Heart;Hepatocyte;high volume manufacturing;Human;Human Characteristics;human tissue;Image;Immunotherapy;improved;In Vitro;induced pluripotent stem cell;Industry;Injections;innovation;instrumentation;interest;Intuition;Laboratories;Liquid substance;lithography;live cell imaging;Liver;manufacturability;manufacture;manufacturing process;Marketing;Methods;Microfluidics;microphysiology system;Microscope;Microscopic;microscopic imaging;model development;Modeling;Modernization;Molds;Monitor;Morphology;mosaic;Names;novel;novel therapeutics;organ on a chip;Organoids;Perfusion;pharmacologic;Phase;Phenotype;Physiological;Pluripotent Stem Cells;pressure;Process;Production;programs;Property;Protocols documentation;prototype;Reagent;Research;research and development;Schedule;screening;scripting interface;sensor;spheroids;Standardization;stem cells;Suspension Culture;System;Systems Integration;Technology;therapy development;Tissue Model;Tissues;tool;Toxic effect;Tube;tumor;United States National Institutes of Health;user-friendly;Vascularization;Work

PROJECT_TITLE: Programmable Microfluidic Perfusion Bioreactor for 3D Organoid Culture and Screening Applications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Patient Safety;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases;Rehabilitation

ORG_NAME: VOXEL HEALTHCARE, LLC

PHR: Narrative Radiation therapy is often a lifesaving treatment for pediatric brain tumor patients, but simultanously may cause radiation toxicity to surrounding healthy tissues in the brain. Mitigating tissue damage is necessary in order to avoid long-term developmental side effects to these children; our ClickBrain RT software will use deep learning technologies to automatically delineate key structures in the brain and predict volumetric changes that occur due to treatment-related radiation dosing to these key structures. This will help physicians to better avoid unnecessary radiation doses that may cause long-term deficits in children with brain tumors and can ultimately lead to better quality of life for these children.

PI_NAMEs: LEPORE, NATASHA ;LOW, JUSTIN  (contact);OLCH, ARTHUR JACOB

PROGRAM_OFFICER_NAME: DJEMIL, SARRA

PROJECT_TERMS: Address;Adult;Affect;Age;Algorithms;Anatomy;Area;autoencoder;automated segmentation;Basal Ganglia;behavioral health;Brain;brain magnetic resonance imaging;Brain Neoplasms;brain tissue;cancer imaging;Caregivers;chemotherapy;Child;Child health care;Childhood;Childhood Brain Neoplasm;Cicatrix;Clinic;Clinical;Clinical Data;clinical decision support;cloud based;Cognition;Cognitive;cognitive development;Computer software;Consultations;convolutional neural network;Cost Savings;Cranial Irradiation;Data;Data Set;Databases;deep learning;demographics;design;Development;dosage;Dose;Exposure to;feature extraction;Feedback;Focus Groups;follow-up;Gender;generative adversarial network;Germ cell tumor;Germ Cells;Goals;graphical user interface;Healthcare;Hippocampus;hospital services;Hospitals;Hour;Hybrids;Image;improved;Individual;Intensity-Modulated Radiotherapy;Late Effects;Life;Location;Longterm Follow-up;Los Angeles;Machine Learning;machine learning algorithm;machine learning method;machine learning model;Magnetic Resonance;Magnetic Resonance Imaging;Manuals;Measurement;Memory;Methods;Modeling;multilayer perceptron;neural network architecture;Neurocognitive;neurocognitive test;Neurological outcome;Neuropsychological Tests;novel;Occupational Therapy;Online Systems;Operative Surgical Procedures;Organ;Outcome;outcome prediction;Output;Paint;Patient Self-Report;Patients;Pediatric Hospitals;pediatric patients;Phase;Physical therapy;Physicians;Population;Prediction of Response to Therapy;predictive tools;Probability;Process;processing speed;prospective;prototype;Provider;Quality of life;Radiation;Radiation Dose Unit;radiation during childhood;radiation effect;Radiation induced damage;Radiation Oncologist;Radiation therapy;Radiation Toxicity;Radiologic Technology;Recommendation;Recording of previous events;Risk;scale up;Scanning;segmentation algorithm;Services;Shapes;Short-Term Memory;Shunt Device;side effect;simulation;skills;Software Tools;Speech Therapy;Speed;standard of care;Structure;Survivors;System;targeted treatment;Techniques;Technology;TensorFlow;Testing;Thinking;Time;Tissues;tool;Toxic effect;Training;treatment choice;treatment optimization;Treatment outcome;treatment planning;treatment risk;tumor;user-friendly;Validation;Visit;Work;X-Ray Computed Tomography

PROJECT_TITLE: Long term radiation treatment planning in brain tumors in the pediatric population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Dental, Oral, and Craniofacial Disease;Nanotechnology;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Wound Healing and Care

ORG_CITY: DECATUR

ORG_NAME: ORIDIVUS LLC

ORG_STATE: GA

PHR: NARRATIVE Wound healing complications occur following cleft palate repair and wisdom teeth removal at rates of about 60% and 25%, respectively. Oral cavity trauma after injury or cancer surgery can also lead to wound healing problems. Such complications can lead to poor feeding, speech problems, prolonged recovery and, ultimately, revision surgery. During this project we will test a therapy to promote more rapid and complete wound healing.

PI_NAMEs: GOUDY, STEVEN L (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Absenteeism at work;Adoption;Affect;Allogenic;Allografting;alveolar bone;Alveolar periostitis;Animal Model;Area;Bacteria;Blood Platelets;Bone Regeneration;cancer surgery;cell motility;Cells;Child;Chronic;chronic pain;Cleft Palate;Clinical;Clinical Trials;comparative efficacy;Controlled Study;cost;Cues;Data;Defect;density;Dental;Dermal;Dermis;Dose;Drug Delivery Systems;Eating;efficacy testing;Environment;Excision;experimental study;Family suidae;FDA approved;feeding;Fistula;Future;Generic Drugs;Goals;healing;health care service utilization;Histologic;HIV;Hour;Human;Immune;immune modulating agents;Immune response;immunoregulation;Immunotherapy;Implant;improved;In Vitro;in vivo;Incidence;Inflammation;Inflammatory;Inflammatory Response;Injury;innovation;Lead;Live Birth;Liver;lymph nodes;Macrophage;Measures;Methods;Microscopic;migration;Miniature Swine;Modeling;monocyte;Morbidity - disease rate;mouse model;Mucous Membrane;Multiple Sclerosis;multiple sclerosis patient;Mus;nanofiber;Nanofiber Scaffold;National Institute of Dental and Craniofacial Research;neutrophil;novel;off-label use;Operative Surgical Procedures;Oral;Oral cavity;Oral Characters;Oral Contraceptives;Oral mucous membrane structure;Oral Surgical Procedures;Outcome Measure;Pain;Palate;palate repair;Pathway interactions;Patients;Performance;Pharmaceutical Preparations;Phase;Phenotype;Plasma;Polymers;porcine model;Prions;Procedures;Process;Publications;Publishing;Punch Biopsy;Recovery;recruit;regenerative;Regenerative capacity;regenerative cell;regenerative therapy;Regenerative wound healing;Relapse;Reporting;Research;Risk;Rodent;Rodent Model;Safety;scaffold;Scientist;Second Look Surgery;Serum;Signal Transduction;Site;Smoker;spatiotemporal;Speech;Sphingosine;Spleen;standard care;Surgeon;Technology;Testing;therapy development;tissue regeneration;Tissues;Toxicology;Translations;transmission process;Trauma;Traumatic injury;Vascularization;wisdom tooth;Woman;wound;wound closure;wound healing

PROJECT_TITLE: Innovative oral regenerative therapy leveraging immunoregenerative mechanisms.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MSOS-D (10)]


NIH_SPENDING_CATS: Asthma;Bioengineering;Chronic Obstructive Pulmonary Disease;Clinical Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Physical Activity;Prevention;Telehealth

ORG_CITY: ATLANTA

ORG_NAME: STETH X MICROSYSTEMS, INC.

PHR: Project Narrative  Respiratory disorders such as chronic obstructive pulmonary disease (COPD) and asthma are among the leading causes of disability and death globally, which are currently widely underdiagnosed, undertreated, and often undermanaged over time. In this project, we will develop an easy-to-use smart wearable lung monitor based on a proprietary contact microphone technology to enable extended monitoring and analysis of lung sounds and breathing function with a higher sensitivity than medical-grade digital stethoscopes and in a significantly smaller form-factor. The wearable patch developed in this project aims to help with remote monitoring of patients outside of the hospital, facilitating early diagnosis, and reducing the risks and cost associated with management of respiratory diseases.

PI_NAMEs: WEN, HAORAN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Accelerometer;Acoustics;Address;Adhesives;Algorithms;Asthma;Auscultation;automated algorithm;Benchmarking;Breathing;Cardiopulmonary;Caring;Cause of Death;Cessation of life;Chest;Chronic;Chronic Obstructive Pulmonary Disease;Classification;classification algorithm;Clinic;Clinical;commercialization;Computer software;Consumption;cost;Crackles;Custom;Data;data acquisition;Dependence;design;Detection;Development;Devices;Diagnosis;Diagnostic Procedure;digital;disability;Disease;disease diagnosis;Disease Management;Early Diagnosis;Economic Burden;electric impedance;Electronics;Ensure;Evaluation;evidence base;experience;fabrication;Feasibility Studies;feature extraction;Frequencies;Goals;Grain;graphical user interface;Head;Healthcare Systems;Heart Rate;Heart Sounds;hospital readmission;Hospitalists;Hospitals;Immune;improved;innovation;Institutional Review Boards;Internist;Legal patent;Licensing;Location;Lung;Lung Diseases;machine learning algorithm;manufacturing process;Marketing;Measurement;Measures;Medical;microelectronics;microphone;microsensor;miniaturize;miniaturized sensor;Monitor;Morbidity - disease rate;mortality;Motion;Noise;noninvasive diagnosis;North America;novel;particle;Pathologic;Pathway interactions;Patient Monitoring;Patients;Pattern;Performance;Persons;phantom model;Phase;phase 2 designs;Physical activity;Physicians;Play;Positioning Attribute;Preventive screening;Process;prototype;pulmonary function;remote monitoring;remote patient monitoring;Research;Research Personnel;Respiration;Respiration Disorders;respiratory;Respiratory Disease;respiratory health;Respiratory Sounds;Respiratory System;Respiratory Tract Infections;Rice;Risk;Role;Running;seal;sensor;Signal Transduction;skills;Skin;Software Design;sound;Stethoscopes;Surface;Symptoms;System;Technology;Testing;Time;Training;Universities;user-friendly;vibration;Visit;wearable device;Wheezing;wireless

PROJECT_TITLE: A smart wearable contact microphone patch for extended and remote monitoring of lung functions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-S (11)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Hematology;Immunization;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Prevention;Rare Diseases;Vaccine Related

ORG_CITY: MIAMI

ORG_NAME: STINGINN, LLC

ORG_STATE: FL

PHR: PROJECT NARRATIVE Human T cell leukemia virus type-1 (HTLV-1) is a human retrovirus that is the causative agent of a malignant T CD4+ cell lymphoproliferative disorder referred to as adult T cell leukemia/lymphoma (ATLL), as well as several inflammatory disorders with the most problematic being HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Remarkable, while millions are affected worldwide, there is no effective vaccine or treatment options to prevent ATLL or HAM/TSP afflicted individuals. We thus aim here, to develop a candidate immunotherapeutic vaccine to prevent and plausibly treat HTLV1-associated disease.

PI_NAMEs: AHN, JEONGHYUN ;BARBER, GLEN N (contact);RAMOS, JUAN CARLOS

PROGRAM_OFFICER_NAME: LOU, XING-JIAN

PROJECT_TERMS: Adult T-Cell Leukemia/Lymphoma;Affect;Africa;aged;Area;Attenuated;Australia;Award;Binding;bZIP Domain;Caribbean region;CD4 Positive T Lymphocytes;Cell fusion;Cells;Clinical;Communities;Cytotoxic T-Lymphocytes;Data;design;Detection;Development;Disease;Dose;efficacy testing;Evaluation;Event;Exhibits;experience;Florida;Future;genetic regulatory protein;Giant Cells;Glycoproteins;Happiness;Human;Human T-lymphotropic virus 1;Human T-lymphotropic virus 2;Immunization;immunogenicity;Immunotherapeutic agent;Individual;Infection;Inflammatory;insight;Japan;Knowledge;Lymphoproliferative Disorders;Malaise;Malignant - descriptor;Malignant Neoplasms;manufacture;Mediating;Middle East;Monitor;mouse model;mutant;Nerve Tissue;Nervous System;neutralizing antibody;novel;novel vaccines;Oncolytic;Persons;phase II trial;Plaque Assay;prevent;Production;Proliferating;Proteins;receptor;recombinant viral vector;Reporting;Retroviridae;Reverse Transcriptase Polymerase Chain Reaction;Safety;seropositive;Small Business Technology Transfer Research;South America;Spinal Cord Diseases;Symptoms;T-Lymphocyte;Taxes;Tertiary Protein Structure;therapeutic vaccine;transcription factor;Tropical Spastic Paraparesis;United States;vaccine candidate;vaccine development;Vaccines;vector;Vesicular stomatitis Indiana virus;Viral;Viral Proteins;Viral Vaccines;Viremia;Virus

PROJECT_TITLE: Human T Cell Lymphotropic Virus Vaccine Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 DCAI-D (10)]


ED_INST_TYPE: SCHOOLS OF EDUCATION

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: MADISON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Proper spindle positioning and establishment of the cell division plane is critical for tissue morphogenesis, cell fate specification, and development, and varies among symmetric and asymmetric divisions. While the machinery responsible for anchoring and moving the spindle is well-characterized, many features of its dynamic regulation are poorly understood. I seek to characterize how such features work and how they make flexible control of spindle positioning possible.

PI_NAMEs: SEPANIAC, LESLIE A (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Adhesions;Architecture;Asparagine;Back;Behavior;Cell Adhesion;cell determination;Cell Differentiation process;Cell division;cell fate specification;Cell Physiology;Cell Polarity;Cells;Cellularity;Chronic;Complex;Cytoplasm;Data;daughter cell;Defect;Development;Dissociation;Dominant-Negative Mutation;Dynein ATPase;Embryo;embryo stage 2;Ensure;experimental study;flexibility;Genetic;Glycine;Image;Impairment;Intercellular Junctions;knock-down;Knock-out;Leucine;Location;mast cell;mechanical force;Mediating;Mitosis;Mitotic;Mitotic spindle;Mitotic Spindle Apparatus;Modeling;Molecular;Monomeric GTP-Binding Proteins;Morphogenesis;Neoplasm Metastasis;Nuclear;optogenetics;Organism;Participant;polarized cell;Positioning Attribute;Process;Proteins;Regulation;RNA Interference;Role;stem;stem cells;System;temporal measurement;Testing;Tissues;tumor;Vertebrates;Work;Xenopus

PROJECT_TITLE: Cdc42-mediated regulation of spindle positioning in a vertebrate model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-Q (20)]


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: Project Narrative Single cell mRNA sequencing (scRNAseq) data previously generated from the human fetal intestine indicates that one of the potential intestinal epithelial niche-supporting populations of the intestinal mesenchyme is the sub-epithelial cells (SECs). This mesenchymal sub-population is located immediately adjacent to the intestinal epithelium, can be defined by PDGFRahi/F3+ gene expression, and was recently determined to not be a homogenous population; but rather there are distinct, mutually exclusive identities localized to the crypt and villus SECs (Holloway, 2021). This proposal aims to use iPSC-derived HIO cultures to 1) interrogate the role of crypt-based SECs as a potential source of niche signaling and 2) to investigate the role of HGF signaling in maintenance of the intestinal stem cells (ISCs).

PI_NAMEs: JOHNSON, KELLI  (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Architecture;base;Behavior;Biochemical;BMP3 gene;capsule;Cell Culture Techniques;Cell Maintenance;Cell Physiology;cell type;Cells;Chromosome Mapping;cohort;CRISPR/Cas technology;Cues;Culture Media;CXCL14 gene;CXCR4 gene;Data;Data Set;design;Development;differential expression;EGF gene;Environment;Epithelium;experimental study;F3 gene;fetal;Fetal Development;Fluorescent in Situ Hybridization;Gene Expression;Genes;Goals;Growth and Development function;Heterogeneity;HGF gene;Human;human tissue;IGFBP3 gene;Image;In Vitro;in vivo;induced pluripotent stem cell;inhibitor;insight;intestinal epithelium;Intestines;Kidney;Knock-out;Ligands;loss of function;Maintenance;Malignant Neoplasms;MAP Kinase Gene;media use;Mediating;Mesenchymal;Mesenchyme;MET gene;Methods;MMP11 gene;Modeling;Mus;Natural regeneration;novel;Organ;organ repair;organoid transplantation;Organoids;Pathway interactions;Pattern;PDGFRA gene;pharmacologic;Phosphorylation;PIK3CG gene;Play;Population;Protein Secretion;Publishing;receptor;Receptor Protein-Tyrosine Kinases;Role;Secretory Cell;self-renewal;Signal Transduction;Signaling Molecule;single cell mRNA sequencing;single-cell RNA sequencing;Source;Stains;stem cell growth;stem cell niche;stem cell population;stem cells;stromelysin 3;Testing;Time;Tissues;Transplantation;Villus;Western Blotting;wound healing

PROJECT_TITLE: Interrogating sub-epithelial cell heterogeneity in the developing human intestinal stem cell niche

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-7 (O1)]


ORG_CITY: JESSUP

ORG_NAME: DYNAFLOW, INC.

ORG_STATE: MD

PHR: Success of this research will help in developing a better understanding of the complex phenomena of microbubble enhanced sonothrombolysis. The developed software, having both proven accuracy and efficiency, will be marketed as a research platform for fundamental studies, a design tool for therapy planning and to decrease the time required for FDA approval of new microbubble enhanced ultrasound based therapies.

PI_NAMEs: MA, JINGSEN  (contact)

PROGRAM_OFFICER_NAME: WARREN, RONALD Q

PROJECT_TERMS: Acceleration;Acoustics;Address;Basic Science;Benchmarking;Biophysics;Blood coagulation;Cause of Death;Cells;Cessation of life;clinical application;Coagulation Process;Code;Complex;computerized tools;conventional therapy;Coupled;Coupling;Cytolysis;Dependence;design;Development;disability;Discipline;Evolution;Excision;experimental study;FDA approved;Focused Ultrasound Therapy;Funding;Goals;Health Benefit;High Performance Computing;high risk;Image;In Vitro;in vivo;innovation;insight;laboratory experiment;Liquid substance;Marketing;meetings;Methods;Microbubbles;Modeling;Morphology;Motion;novel;operation;Outcome;Performance;Persons;Phase;Physics;Procedures;Property;Protocols documentation;Research;Research Personnel;Risk Reduction;Rupture;Scheme;side effect;simulation;Small Business Innovation Research Grant;software development;Speed;Stress;Structure;success;Surface;Technology;Testing;therapy development;thrombolysis;Thrombosis;Time;Tissues;tool;tumor ablation;Ultrasonics;ultrasound;United States;United States National Institutes of Health;user-friendly;Validation;viscoelasticity;Viscosity;welfare

PROJECT_TITLE: A Numerical Platform for Microbubble Enhanced Sonothrombolysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-V (10)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Cystic Fibrosis;Genetics;Infectious Diseases;Lung;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE Cystic fibrosis (CF) affects more than 100,000 people worldwide and causes the formation of thick mucus in the lungs, leading to the chronic infection of various pathogens that are prone to developing antibiotic tolerance. This application proposes that preexposure to bacterial extracellular vesicles leads to epigenetic changes in host bronchial epithelial cells that alter the host immune response, contributing to the establishment of chronic lung infections. The project will serve as a foundation for the candidate to develop skills as an academic researcher and could lead to the development of novel therapeutic treatments for CF.

PI_NAMEs: CHARPENTIER, LILY  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Affect;Anoxia;Antibiotic Resistance;antibiotic tolerance;Antibiotics;ATAC-seq;Bacteria;Bioinformatics;bronchial epithelium;Cell secretion;Chronic;chronic infection;Clinical;Clinical Data;Collaborations;Communication;Cystic Fibrosis;cystic fibrosis mucus;Cystic Fibrosis Transmembrane Conductance Regulator;cytokine;Data;deprivation;Development;Diffuse;DNA;DNA analysis;DNA Methylation;Environment;Epigenetic Process;Epithelial Cells;experience;exposed human population;Exposure to;extracellular vesicles;Foundations;Gene Expression;Gene Silencing;Genetic Transcription;Goals;Growth;Human;Immune;Immune response;improved;in vitro Model;Infection;insight;Life;Lung;Lung infections;Measures;Membrane;methylation pattern;Modeling;Morbidity - disease rate;mortality;Mucins;Mucociliary Clearance;mucoid;Mucous body substance;new therapeutic target;novel;novel therapeutics;Outcome;Oxygen;pathogen;pathogenic bacteria;Persons;Phenotype;Physiological;Prevotella;Prevotella melaninogenica;Proteins;Proteome;Proteomics;Pseudomonas aeruginosa;Publishing;Pulmonary Cystic Fibrosis;pulmonary function;Research Design;Research Personnel;response;RNA;secondary infection;Secondary to;siRNA delivery;skills;Small Interfering RNA;Sputum;Staphylococcus aureus;Staphylococcus aureus infection;Streptococcus sanguis;Techniques;Testing;Thick;Time;Training;transcriptomics;treatment response;Vesicle;Virulence;Virulence Factors;Work

PROJECT_TITLE: Host-Pathogen Interactions in a Cystic Fibrosis Polymicrobial Infection Model

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07A-B (20)]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: Atlanta

ORG_NAME: KDH RESEARCH AND COMMUNICATION, INC.

PHR: Women in the U.S. are twice as likely to die from maternal complications when compared to other high-income countries, and over half of maternal deaths in the U.S. occur postpartum. Many Black Indigenous and People of Color (BIPOC) women receive support from doulas and midwives (birth workers) during birth and for one week after birth. Community health workers are in an ideal position to support women postpartum during a time when women no longer receive support from birth workers. KDHRC's proposed program, Effective Newborn Community-Outreach Recovery Engagement (ENCORE), will train community health workers to support postpartum BIPOC women through outreach that builds knowledge and skills to support postpartum BIPOC women, particularly women who no longer receive support from birth workers, improving postpartum outcomes and reducing postpartum health disparities.

PI_NAMEs: COOPER, DEXTER L (contact)

PROGRAM_OFFICER_NAME: LINARES, DEBORAH ELIZABETH

PROJECT_TERMS: Address;Adoption;Advisory Committees;Alaska Native Women;American Indian Women;Applications Grants;Awareness;barrier to care;behavior change;Birth;Black race;Black, Indigenous, People of Color;Caring;Cessation of life;child bearing;Communication;Communities;Community Health Aides;Community Outreach;cost effectiveness;Country;course development;cultural competence;Death Rate;delivery complications;E-learning;education resources;Effectiveness;Electronic Mail;Ensure;Evaluation;evaluation/testing;evidence base;Exhibits;experience;Exposure to;Feedback;hands-on learning;Health;health disparity;improved;Income;Infant;Infant Care;Infant Health;Infant Mortality;innovation;Intervention;Knowledge;Learning;life span;Low Birth Weight Infant;Marketing;Maternal complication;Maternal Health;Maternal Health Services;Maternal Mortality;Measures;Mental Health;mental state;Midwife;mortality;Mothers;Newborn Infant;online course;outreach;people of color;Persons;Phase;physical conditioning;physical state;Population;Positioning Attribute;postpartum health;postpartum morbidity;postpartum outcome;Postpartum Period;Postpartum Women;Pregnancy;Pregnancy Complications;Premature Birth;Process;programs;prototype;psychologic;Quality of life;Randomized;Randomized, Controlled Trials;Recovery;Reporting;reproductive;Research;Resources;Sales;Self Efficacy;skill acquisition;skills;Small Business Innovation Research Grant;social;social health determinants;success;System;Testing;Text;Time;tool;Training;Training Programs;Trust;virtual education;White Women;Woman;women of color

PROJECT_TITLE: Effective Newborn Community-Outreach Recovery Engagement (ENCORE) - a culturally appropriate professional development course for community health workers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-D (10)]


NIH_SPENDING_CATS: Contraception/Reproduction;Infertility

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: PS-FERTILITY, INC.

ORG_STATE: VA

PHR: Public Health Relevance Infertility affects 1 in 8 couples in the United States and ~40% is due to a male cause. Current semen analysis only counts sperm number, assess the morphology and motility, this does not provide information on a sperm's ability to actually fertilize an oocyte. It is widely accepted that if a sperm looks normal, is motile, and there are many of them in a sample, then a male is likely fertile; but this assumption is flawed as many men have normal semen parameters yet are infertile. At PS Fertility we are marketing a Synthetic Egg:Sperm Fusion Assay (SEFA) a diagnostic test that will assess the ability of the sperm to fuse/fertilize an oocyte.

PI_NAMEs: LYSIAK, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: KENT, TRAVIS JOHN

PROJECT_TERMS: Affect;Agreement;Apoptotic;assistive reproductive technique;Binding;Biological Assay;Businesses;Cattle;Cells;Characteristics;CLIA certified;Clinic;Clinical;cohort;Collection;commercialization;Communities;Competence;Couples;Development;Diagnostic;diagnostic assay;Diagnostic tests;diagnostic tool;economic cost;egg;Ejaculation;Emotional;Ensure;Ethics;Event;Exposure to;Fertility;Fertilization;Future;Germ Cells;Goals;Hamsters;Health;Human;Impairment;improved;Infertility;infertility treatment;Innovation Corps;Knowledge;Laboratories;Laboratory Finding;Legal patent;Licensing;Ligands;Link;Lipids;Logistics;male;male fertility;Male Infertility;Management Information Systems;Market Research;Marketing;men;men's group;Modeling;Molecular;Morphology;Motility;Mus;Muscle Cells;Muscle Fibers;Myoblasts;Nature;Normal Range;novel;Oocytes;operation;Outcome;Patients;Performance;Phase;phase 2 study;phosphatidylserine receptor;Phosphatidylserines;Pilot Projects;Procedures;programs;Property;Protocols documentation;public health relevance;receptor;Reporting;Research;Sample Size;Sampling;scale up;Science;Seminal fluid;Sensitivity and Specificity;Services;Shipping;Small Business Innovation Research Grant;Specimen;sperm cell;Sperm Count Procedure;sperm function;Sperm Motility;sperm viability;stem;Surface;Techniques;Technology;Testing;United States;Universities;Virginia;Work;zygote

PROJECT_TITLE: Synthetic Egg:Sperm Fusion Assay (SEFA): A Diagnostic Test for Male Fertility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 EMS-K (10)]


NIH_SPENDING_CATS: Genetics;Infectious Diseases;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Project Narrative It has long been observed that disease severity and outcomes are different in males and females, yet we don’t know why. The goal of my proposed project is to answer this question by looking at differences in T cell metabolism between males and females, and how they relate to viral infection outcomes. Understanding the biology of sex differences in T cells, metabolism, and infection will offer context to sex differences in immunity as well as new sex-specific therapies for infection.

PI_NAMEs: KLINE, JACLYN  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acute;adaptive immune response;Address;Adipose tissue;Adoptive Transfer;Androgen Receptor;Autoimmune Diseases;Autoimmunity;Automobile Driving;Biological;Biological Assay;Biological Factors;Biology;Biomedical Research;Body Temperature;burden of illness;career;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Metabolic Process;Chromosomes;Circulation;Communicable Diseases;comparative;Coupled;cytotoxic;Development;Disease;Disease Outcome;drug development;Environment;Estrogen Receptors;Evaluation;Event;fatty acid oxidation;Female;Flow Cytometry;Four Core Genotypes;Future;Genus Hippocampus;Goals;Gonadal Steroid Hormones;Health;Hormone Receptor;Hormones;Human;human female;Image;Immune;immune function;Immune system;Immunity;Immunologic Stimulation;in vivo;Incidence;Infection;infection risk;Injections;Innate Immune Response;insight;Knockout Mice;lipid metabolism;Liver;Lymphocytic choriomeningitis virus;male;Malignant Neoplasms;Measures;Mediating;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Mitochondria;Modeling;mortality;mouse model;Mus;novel therapeutics;Organ;Outcome;Ovalbumin;pathogen;Pathogenesis;Pathology;Pathway interactions;Ploidies;Proteins;Reporting;Research;research and development;response;Severity of illness;sex;Sex Bias;Sex Chromosomes;Sex Differences;sexual dimorphism;Shapes;Signaling Molecule;Stimulus;T cell response;T-Cell Activation;T-Cell Proliferation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Time;tool;Training;Transcript;Vaccinia virus;Viral;Virus;Virus Diseases;Wild Type Mouse

PROJECT_TITLE: Sex Differences in T cell metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F07B-G (20)]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Machine Learning and Artificial Intelligence;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Rural Health;Telehealth;Women's Health Research

ORG_CITY: LOUISVILLE

ORG_NAME: TELE-STETHOSCOPE INC.

ORG_STATE: KY

PHR: The research supports development of technology that allows ordinary mobile phones to be used to detect preeclampsia and hypertension in patients remotely. The intent is to improve access to care as well as the ability to increase monitoring frequency. The technology is scientifically important in that it uses a novel hemodynamics based approach in creating classifier algorithms from passively received time series data.

PI_NAMEs: HEIRONIMUS, JOHN CONRAD;HUECKER , MARTIN RICHARD;WOLFSON, DAVID  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Acoustics;Affect;Algorithms;Ambulatory Care Facilities;American;Aorta;arm;Auscultation;Black race;Blood Pressure;Cardiopulmonary;Cause of Death;Cellular Phone;Classification;classifier algorithm;clinical practice;commercialization;comorbidity;Complication;Computer software;cost;Country;COVID-19 detection;Custom;Data;Death Rate;demographics;Detection;Devices;Diagnosis;Diagnostic;Disease;Drops;Early Intervention;Echocardiography;EFRAC;Emergency Medicine;Enrollment;Evaluation;First Pregnancy Trimester;Frequencies;Grant;Health;Health Care Costs;Health Services Accessibility;hemodynamics;high risk;Home;Hospitals;human study;Hypertension;Improve Access;improved;improved outcome;innovation;Inpatients;Intelligence;invention;Label;Left;Linear Regressions;Location;Logistic Regressions;Machine Learning;maternal morbidity;Maternal-fetal medicine;Mathematics;Measurement;Medicaid;Medical;Medical Imaging;microphone;Modeling;Monitor;mortality;Neonatal;neonatal morbidity;neural network;Nigeria;Nonlinear Dynamics;novel;Office Visits;Patients;Peer Review;Performance;Physical Examination;Physicians;Physics;Pre-Eclampsia;predictive modeling;Pregnancy;pregnancy hypertension;Pregnant Women;Process;Protocols documentation;Provider;Publishing;recruit;Regression Analysis;remote monitoring;Research;Research Support;Running;Rural;rural patients;Sampling;Science;Self-Examination;Sensitivity and Specificity;Series;Site;Slice;Somatotype;stability testing;standard of care;Talents;Technology;technology development;Telephone;Testing;Time;Training;Underserved Population;Uninsured;Upper arm;Urinalysis;Variant

PROJECT_TITLE: A novel mobile phone technology to improve access for preeclampsia and hypertension detection


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project narrative  This project aims to 1) evaluate the role of metals and metal mixtures in the risk of coronary heart disease (CHD); 2) to assess the genetic susceptibility to the effect of metals and metal mixtures on the risk of CHD; and 3) to identify the potential urinary metabolites that are associated with both CHD risk and metals/metal mixtures. We will pool data from three prospective cohorts consisting of diverse populations. This study can provide insight into the relationship between metal exposures and CHD risk, with implications for preventing and controlling exposures in the US and abroad.

PI_NAMEs: AHSAN, HABIBUL ;CHEN, YU  (contact);NAVAS-ACIEN, ANA

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Accounting;Adult;American Indians;Arsenic;Bangladesh;Biological;Biology;Black American;Candidate Disease Gene;Cardiovascular system;caucasian American;Cessation of life;Chinese American;Cities;Clinical;cohort;Cohort Studies;Coronary heart disease;Data;Data Pooling;Development;disability;Disease;Disease Pathway;disorder risk;Dose;Elements;Environmental Exposure;Environmental Health;Environmental Risk Factor;epidemiology study;Exposure to;Family Study;gene interaction;Genes;Genetic;Genetic Markers;Genetic Predisposition to Disease;Genetic study;genetic variant;genome wide association study;genome-wide;Goals;ground water;Health;health data;Heart;heart disease risk;Heart Diseases;high risk population;Hispanic Americans;improved;Individual;insight;Knowledge;Longitudinal Studies;Masks;Measurement;Measures;Mediating;Mediation;member;metabolomics;Metal exposure;Metals;Methods;Modeling;Molecular Weight;Monitor;mortality;Multi-Ethnic Study of Atherosclerosis;National Institute of Environmental Health Sciences;novel;Pathway interactions;Pattern;Persons;Play;Population;Population Heterogeneity;prevent;Prevention;prospective;Prospective cohort;Prospective, cohort study;Public Health;recruit;Reporting;Reproducibility;Research;Resources;response;Risk;Risk Factors;Role;Sample Size;Sampling;Sampling Studies;Strategic Planning;study population;Subgroup;Testing;Toxic effect;toxic metal;trait;urinary;Variant

PROJECT_TITLE: Exposure to Metal-Mixtures and Coronary Heart Disease Across Diverse Populations

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Precision Medicine

ORG_NAME: SOSTOS LLC

PHR: Project Narrative Sostos, LLC is developing an assay that addresses the high incidence of tumor recurrence in patients with non- small cell lung cancer (NSCLC) at the time of primary tumor surgical resection. Our technology identifies NSCLC as at high risk of progression and recurrence of cancer for patients who will benefit from earlier therapeutic intervention. Using qRT-PCR of formalin-fixed paraffin-embedded (FFPE) tumors, we anticipate that our product will become part of the standard of care for early-stage NSCLC patients, at the time of surgical resection of the primary tumor, for identifying those at high-risk who would benefit from early implementation of adjuvant therapy to prevent tumor progression and recurrence – years before otherwise identified – and thus, improving overall patient care and outcome for those with lung cancer.

PI_NAMEs: GUO, NANCY LAN;YE, QING  (contact)

PROJECT_TERMS: Accreditation;Address;Adjuvant Chemotherapy;Adjuvant Therapy;Algorithms;American;Archives;Artificial Intelligence;artificial intelligence method;Award;Biological Assay;Biological Markers;biomarker panel;Blood Vessels;Cancer Patient;cancer recurrence;Caring;chemotherapy;Clinical;clinical application;clinical predictors;Clinical Research;cohort;Collaborations;commercialization;Computer software;cost effective;Data;Data Analyses;Death Rate;Development;Devices;Diagnosis;Diagnostic;Diagnostic tests;Disease Management;Early identification;Early treatment;Evaluation;Excision;experience;feasibility testing;follow-up;Formalin;Freezing;gene panel;Genes;Genetic Markers;genotyped patients;Goals;Guidelines;Health system;high risk;Histologic;Histology;Hospitals;improved;Incidence;Instruction;Invaded;Laboratories;Large Cell Carcinoma;Legal patent;Lung Adenocarcinoma;lymph nodes;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Medical Device;meetings;Microfluidics;molecular marker;National Comprehensive Cancer Network;Neoplasm Metastasis;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel;Oncologist;Oncology;Operative Surgical Procedures;Paraffin Embedding;Pathology;Patient Care;patient prognosis;Patient-Focused Outcomes;Patients;Phase;phase 1 study;Phase III Clinical Trials;Phenotype;Physicians;Pleural;predict clinical outcome;prediction algorithm;prevent;Primary Neoplasm;Prognosis;prognostic;prognostic assays;progression risk;Proteomics;prototype;Quantitative Reverse Transcriptase PCR;Randomized;Recurrence;Recurrent tumor;Reporting;Resectable;Risk;risk prediction;Sampling;Small Business Innovation Research Grant;software development;Source;Specificity;Squamous cell carcinoma;standard of care;success;Suggestion;Technology;Testing;The Cancer Genome Atlas;Therapeutic Intervention;Time;Tissues;Training;transcriptome sequencing;tumor;tumor progression;Validation;Visceral

PROJECT_TITLE: Accurate prognosis and prediction of clinical benefits of adjuvant therapy for early-stage non-small cell lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDPT-V (13)]


NIH_SPENDING_CATS: Asthma;Biotechnology;Health Effects of Indoor Air Pollution;Lung

ORG_CITY: Temecula

ORG_NAME: PARMEDICS, INC.

PHR: PROJECT NARRATIVE PARMedics is developing a PAR2 biased antagonist, C781, that can reduce airway inflammation and bronchoconstriction. Results from Phase I indicate that C781 may be effective in combating acute allergen- induced asthma exacerbations as well as the underlying pathology, through reducing the cytokine production and cellular infiltration associated with chronic disease. In this SBIR Phase II, PARMedics will further develop C781 as a new class of therapeutics for asthma and other inflammatory lung diseases through relevant IND- enabling preclinical asthma models.

PI_NAMEs: BOITANO, SCOTT ;DEFEA, KATHRYN ANNE (contact)

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;adverse outcome;aerosolized;Aerosols;Affect;Agonist;airway hyperresponsiveness;airway inflammation;Allergens;Alternaria;American;Animal Model;antagonist;Antibodies;Arizona;ARRB2;Asthma;asthma exacerbation;asthma model;asthmatic;asthmatic patient;beta-adrenergic receptor;beta-arrestin;Binding;Biochemistry;Biological;Biological Assay;Blood;Bronchioles;Bronchoconstriction;Businesses;Canis familiaris;Cardiotoxicity;cardiovascular risk factor;Cellular Infiltration;Cessation of life;chemokine;Child;Chronic;Chronic Disease;chronic inflammatory lung disease;Clinical Research;Clinical Trials;clinically significant;Complex;constriction;cytokine;Deposition;Development;Devices;Diameter;Dictyoptera;Disease;Dose;Drug Exposure;drug inhalation;Drug Kinetics;effective therapy;efficacy evaluation;efficacy study;Elastases;Engineering;eosinophil;Eotaxin;Epithelium;experience;Exposure to;Extrinsic asthma;Facilities and Administrative Costs;Formulation;fungus;Future;G-Protein-Coupled Receptors;Genetically Modified Animals;German population;Goals;Headache;Health;Health Care Costs;Health Expenditures;Hepatotoxicity;High Pressure Liquid Chromatography;Human;Hyperplasia;improved;In Vitro;in vivo;Incidence;Individual;Inflammation;Inflammatory;inflammatory lung disease;Inflammatory Response;Inhalation;Injectable;injured airway;Interleukin-13;Interleukin-4;Interleukin-5;Investigational Drugs;Leukocyte Elastase;Ligands;Lung;manufacture;manufacturing scale-up;MAP Kinase Gene;MAPK3 gene;Maximum Tolerated Dose;Measures;Mediating;Membrane;mepolizumab;methacholine;Modeling;Morbidity - disease rate;mortality;Mucous body substance;Mus;Muscle relaxation phase;Nasopharyngitis;Nebulizer;neutralizing antibody;neutrophil;Neutrophil Infiltration;Nose;novel;novel therapeutics;omalizumab;Outcome;PAR-2 Receptor;Pathology;Pathway interactions;patient subsets;persistent symptom;Persons;Pharmaceutical Preparations;Pharmacology;Phase;Physiological;Physiology;Play;Pneumonia;pre-clinical;Pre-Clinical Model;preclinical study;Process;Production;Productivity;professor;programs;Protease Inhibitor;protective pathway;pulmonary function;pulmonary function decline;pyroglyphid;Quality of life;receptor;recruit;Relaxation;release of sequestered calcium ion into cytoplasm;Resistance;Respiratory Tract Infections;response;Risk;Role;Safety;Sampling;Serine Protease;Severities;Signal Transduction;Small Business Innovation Research Grant;Small Business Technology Transfer Research;Smooth Muscle;Sprague-Dawley Rats;standard of care;Steroids;success;Testing;Therapeutic;TMPRSS2 gene;Toxic effect;Toxicology;Treatment Efficacy;Trypsin;Tryptase;Universities;Work;Xolair

PROJECT_TITLE: Pharmacokinetic and Efficacy Studies of the Aerosolized PAR2 Antagonist, C781, for the Treatment of Asthma


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Precision Medicine

ORG_CITY: CHAPEL HILL

ORG_NAME: TRANSCHROMIX, LLC.

PHR: Data Management and Sharing Plan  No cost associated

PI_NAMEs: CHEN, XIAN  (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: Affective;Affinity;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease therapeutic;Alzheimer's disease therapy;Appearance;Autopsy;Behavior;Behavioral;Binding;Biotinylation;Body Surface Area;Brain;Brain Diseases;brain tissue;Cell Separation;cell type;Cells;Characteristics;chemoproteomics;Chromatin;Clinical;clinically relevant;Coculture Techniques;Cognition;Cognitive;cognitive function;cohort;companion diagnostics;cost;Data;data management;data sharing;Dementia;Development;diagnostic assay;Disease;disease heterogeneity;Disease Progression;Dissection;dosage;Dose;drug action;Drug Kinetics;Drug Targeting;energy efficiency;Epidemiology;Exhibits;Funding;G9a histone methyltransferase;genetic regulatory protein;Genetic Transcription;Hippocampus;histone methyltransferase;Human;human data;Hyperactive behavior;Impaired cognition;improved;induced pluripotent stem cell;inhibitor;innovation;Learning;Measures;Mediating;medical schools;Memory;Memory Loss;Messenger RNA;mouse model;multiple omics;Mus;Nature;Neurodegenerative Disorders;neuroinflammation;Neurons;novel;older adult;Onset of illness;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient stratification;Patients;Pharmaceutical Preparations;Phase;Phosphorylation;Play;prevent;professor;programs;protein expression;Proteins;Proteome;Proteomics;proteostasis;response;RNA Processing;Role;Sampling;Signal Pathway;small molecule inhibitor;Specificity;synaptic function;Synaptic Transmission;synaptogenesis;targeted treatment;tau Proteins;Testing;Therapeutic Effect;therapeutically effective;Tissues;Toxic effect;Translating;Translational Regulation;Translational Repression;Translations;Treatment Efficacy

PROJECT_TITLE: Novel brain-penetrant drugs for translation-targeting therapeutics of Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-P (11)]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Chromatin architecture is intimately connected to gene regulation and its disruption can cause a wide range of diseases. I propose to investigate how Ldb1 (an understudied architectural factor) establishes lineage-specific gene expression programs in the context of erythroid maturation and during cell cycle progression. This work will improve our understanding of normal development and provide insights into how perturbations in chromatin architecture can lead to gene dysregulation in disease.

PI_NAMEs: ABOREDEN, NICHOLAS  (contact)

PROGRAM_OFFICER_NAME: HATTANGADI, SHILPA MANOHAR

PROJECT_TERMS: 3-Dimensional;Acute;Address;Architecture;Automobile Driving;Auxins;beta Globin;Binding;Biological Models;Biological Process;Cell Cycle;Cell Cycle Progression;Cell model;Cell Nucleus;cell type;Cells;ChIP-seq;Chromatin;Chromatin Fiber;Chromatin Loop;Chromatin Structure;cofactor;cohesin;Data;data integration;daughter cell;Development;Disease;DNA Binding Domain;Engineering;Enhancers;Erythroblasts;Erythroid;Erythroid Cells;erythroid differentiation;Etiology;Eukaryota;forging;G1 Phase;Gene Expression;Gene Expression Profile;Gene Expression Regulation;Genes;Genetic Enhancer Element;Genetic Transcription;Genome;genome-wide;Genomics;Glean;Health;Hematopoiesis;Human;improved;insight;Maps;Measures;Mediating;Mitosis;Mitotic;Modeling;molecular mechanics;Mothers;Neighborhoods;Phase Transition;Play;prevent;Process;programs;promoter;Proteins;recruit;Regulatory Element;Role;System;Testing;Time;Tissues;transcription factor;transcriptome;Undifferentiated;Work;YY1 Transcription Factor

PROJECT_TITLE: Investigating the role of Ldb1 in chromatin architecture and transcription during erythroid cell state transitions

STUDY_SECTION_NAME: Special Emphasis Panel[ZDK1 GRB-G (O1)]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Digestive Diseases;Gene Therapy;Genetics;Liver Disease

ORG_CITY: WAUKESHA

ORG_NAME: VECTOR SURGICAL, LLC

PHR: Project Narrative  Liver-directed gene therapies using adeno-associated virus vectors have shown tremendous promise but lack safe, efficient, and economical means of delivery. This project aims to create a specialized gene therapy medical device, the Gene Therapy Catheter, which combines several mechanisms for increasing the uptake of adeno-associated viral vector into one novel device. Based on preliminary data, we estimate that the Gene Therapy Catheter will be able to reduce the cost and volume of adeno-associated viral vector required by 90% compared to systemic delivery.

PI_NAMEs: HAGNESS, SUSAN C;PHILLIPS, JANET  (contact)

PROGRAM_OFFICER_NAME: BROOKS, PJ

PROJECT_TERMS: Ablation;Acceleration;adeno-associated viral vector;adenovirus mediated delivery;Adoption;adverse event risk;Animal Model;Animals;Area;Award;Brightfield Microscopy;Caring;Catheters;Cell Death;cell injury;Cessation of life;Circulation;Climacteric;Clinical;Clinical Research;Clinical Trials;Collaborations;commercialization;cost;Country;Data;Dependovirus;design;design,build,test;Device Designs;Devices;Distal;Doctor of Philosophy;dosage;Dose;Drug Delivery Systems;Effectiveness;electric field;Electrodes;Elements;Engineering;Enzymes;Equation;Excision;Extravasation;Family suidae;flexibility;Fluorescence Microscopy;Flushing;Gene Delivery;gene therapy;gene therapy clinical trial;Gene Transduction Agent;gene-targeted therapy;Goals;Grant;Green Fluorescent Proteins;Hepatocyte;Histologic;Hospitals;Immune;Immune response;immunogenicity;Immunohistochemistry;immunotoxicity;improved;In Vitro;in vivo;Infection;Injections;innovation;Interventional radiology;Letters;Liver;Liver diseases;Lobe;Location;Measures;Mediating;Medical Device;meetings;member;Mendelian disorder;Metabolism;Microscopy;Modality;Monitor;mouse model;neutralizing antibody;novel;Operative Surgical Procedures;Outcome;Pathology;Patients;Performance;Phase;Physiologic pulse;protein expression;prototype;Radial;Recombinant adeno-associated virus (rAAV);Research;risk mitigation;Risk Reduction;Role;Safety;Saline;Serum;Small Business Innovation Research Grant;Stains;Technology;Testing;theories;Therapeutic;Therapeutic Agents;Therapeutic Effect;therapy outcome;Time;tissue injury;Tissues;Toxic effect;transduction efficiency;Transgenic Organisms;Treatment Cost;uptake;vector;Viral Vector;Work

PROJECT_TITLE: Enhanced Gene Therapy Delivery Through Electric Pulsing Double-Balloon Catheter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Endocrine Disruptors;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Nanotechnology;Neurosciences

ORG_CITY: KANNAPOLIS

ORG_NAME: NANODIAGNOSTIC TECHNOLOGY, LLC

PHR: Narrative This research project will specifically focus on the development of a novel biomonitoring platform for onsite sensitive and accurate detection of environmental and occupational exposure to OP pesticides and address several important issues of current approaches for pesticide exposure assessment including high cost, inconvenience, low sensitivity and accuracy, inability to analyze and share biomonitoring data.

PI_NAMEs: WANG, JUN  (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Accident and Emergency department;Acetylcholine;Acetylcholinesterase;Achievement;Acute;Address;Biological Assay;Biological Markers;Biological Monitoring;Biosensor;Blood;Blood specimen;Bluetooth;Butyrylcholinesterase;Cellular Phone;Central Nervous System;Cessation of life;cholinergic;Chronic;Clinical;clinical care;clinically relevant;commercialization;Compensation;computerized data processing;cost;Data;data management;data sharing;Data Storage and Retrieval;Detection;detection method;Development;developmental disease;Devices;Disease;Drops;Education;Electrical Engineering;Environmental and Occupational Exposure;Environmental Health;Enzyme Inhibition;Exposure to;farm worker;field study;Fingers;Foundations;Goals;Health;Health Status;Home;improved;Intervention;Laboratories;Malignant Neoplasms;manufacturing technology;Measurement;Measures;Metadata;meter;Methods;Mission;mobile application;multidisciplinary;Muscle;nanomaterials;nanosensors;Nanotechnology;National Institute of Environmental Health Sciences;Nervous System;neurotoxicity;Neurotransmitters;novel;Occupational Health;organophosphate poisoning;Organophosphates;Paralysed;Parkinson Disease;Patient Care;Patients;Performance;pesticide exposure;pesticide poisoning;Pesticides;Phase;Physicians' Offices;point of care;point-of-care detection;Poison;Poisoning;portability;Process;Public Health;Rapid screening;remote grading;Research;research and development;Research Project Grants;Resistance;risk minimization;Scientist;screening;Site;Small Business Technology Transfer Research;smartphone application;software development;Solid;sound;Symptoms;Synaptic Cleft;System;Technology;Temperature;temporal measurement;Test Result;Testing;Time;tool;toxic organophosphate insecticide exposure;Toxicology;Translating;transmission process;United States;Validation;Whole Blood

PROJECT_TITLE: Development of an integrated smartphone-nanosensor platform for onsite biomonitoring of exposure to pesticides

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-S (12)]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: FAYETTEVILLE

ORG_NAME: ZEBRA ANALYTIX, INC.

ORG_STATE: AR

PHR: Project Narrative Many volatile organic compounds (VOCs) are recognized as toxic or even carcinogenic hazards. The proposed instrument will help protect workers as well as the general public by providing near real-time monitoring of such VOCs in the workplace and the environment.

PI_NAMEs: MICHALEK, JOHN ANTHONY (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Address;Air;Air Pollutants;Benzene;Blood capillaries;Calibration;carcinogenicity;Ceramics;Chemicals;Coal;cold temperature;Column Chromatography;commercial prototype;Computer software;cost;design;Detection;detector;Devices;Electronics;Environment;ethylbenzene;Evaluation;fabrication;Feedback;Gas Chromatography;Gases;General Population;Goals;hazard;health data;Health Hazards;Health protection;improved;Industrialization;Industry;Institution;instrument;Length;manufacturing cost;Measurement;meetings;Metals;method development;Methods;Monitor;Oils;Performance;Petroleum;Phase;phase 2 study;photoionization;pilot test;Play;Power Plants;Process;Production;Protocols documentation;prototype;real time monitoring;Reproducibility;Sampling;sensor;Site;Small Business Innovation Research Grant;Source;Specificity;Time;Toluene;Tube;Validation;volatile organic compound;Workplace;Xylene

PROJECT_TITLE: Autonomous Monitor for Toxic Gas Exposure


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Nanotechnology;Orphan Drug;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: Lowell

ORG_NAME: VERSATOPE THERAPEUTICS, INC.

PHR: Narrative Plasmodium falciparum is the most fatal species among the malaria protozoan parasites infecting humans, resulting in over 400,000 deaths annually, mostly among children living in malaria endemic regions. While approval of the first malaria vaccine was a monumental milestone, its efficacy is limited, providing partial protection in children with only ~30% efficacy. Versatope’s platform has the potential to provide a thermostable vaccine with improved immunogenicity that acts as both a pre-erythrocytic and transmission blocking vaccine, effectively reducing incidence and mortality among this vulnerable population.

PI_NAMEs: LOCHER, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acceleration;Address;Adjuvant;Alhydrogel;Aluminum Hydroxide;aluminum sulfate;Animal Model;Antibodies;Antibody-mediated protection;Antigens;Area;Beds;Biological Assay;Bioreactors;Blocking Antibodies;cell bank;Cell Line;Cessation of life;Chemicals;Child;Clinic;clinical implementation;cost;Culicidae;Cyclic GMP;Developing Countries;Development;Diagnostic;Disease Management;Dose;Drug Metabolic Detoxication;Drug resistance;Early Diagnosis;Engineering;Erythrocytes;Escherichia coli;feeding;flexibility;Freeze Drying;Freezing;Future;global health;health care availability;Human;IL17 gene;Immune response;Immunity;Immunization;immunogenicity;Immunologic Memory;improved;Incidence;Individual;Infant;Infection;Influenza;innovation;Insecticide Resistance;interest;Lipopolysaccharides;Liver;Longevity;Malaria;malaria transmission;Malaria Vaccines;manufacture;manufacturing scale-up;Measures;Membrane;Molecular;mortality;mosquito-borne;nanoparticle;nanovesicle;No-Observed-Adverse-Effect Level;novel;novel strategies;Oryctolagus cuniculus;Parasite resistance;Parasites;pathogen;Pharmacotherapy;Phase;Plasmodium falciparum;poly(lactide);polypeptide;Positioning Attribute;pre-Investigational New Drug meeting;prevent;Probiotics;Process;process optimization;Production;programs;Property;Proteins;Public Health;Readiness;Recombinants;Refrigeration;research clinical testing;Resistance;response;Safety;scale up;Sporozoites;success;T memory cell;Technology;technology platform;Temperature;Testing;Therapeutic;thermostability;Toxic effect;Toxicology;transmission blocking;transmission process;transmission-blocking vaccine;Vaccination;Vaccine Adjuvant;Vaccine Antigen;vaccine candidate;vaccine distribution;vaccine formulation;Vaccines;Vesicle;Viral;Virus-like particle;Vulnerable Populations;Work

PROJECT_TITLE: Recombinant Outer Membrane Vesicles as a Novel Adjuvant for a Malaria Vaccine


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE Staphylococcus aureus is an extremely successful bacteria at causing human diseases. In this study, we examine the ability of methicillin resistant Staphylococcus aureus (MRSA) to degrade fatty acids. These studies will help understand better the metabolic capabilities of this important bacterium.

PI_NAMEs: MENJIVAR, CINDY  (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TERMS: Antibiotics;Awareness;Bacteria;beta-Galactosidase;Bioinformatics;Biological Assay;Biological Process;Carbon;Cell Physiology;Communities;Complement;Complex;Coupled;Culture Media;Data;Death Rate;Degradation Pathway;Disease;DNA;Enoyl-CoA Hydratase;Environment;Enzymes;Escherichia coli;Escherichia coli Proteins;Essential Fatty Acids;Esters;fatty acid biosynthesis;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Future;Genes;genetic regulatory protein;global health;Gram-Positive Bacteria;Growth;high throughput screening;Human;Human body;human disease;Hybrids;In Vitro;in vivo;Individual;Interferometry;Label;Length;Life;Lipopolysaccharides;Lipoproteins;lipoteichoic acid;macromolecule;Mass Spectrum Analysis;Metabolic;Metabolism;methicillin resistant Staphylococcus aureus;Morbidity - disease rate;mutant;Nomenclature;novel;Oleic Acids;Operon;oxidation;pathogen;Pathogenesis;Pathway interactions;Phospholipids;Phosphotransferases;Photometry;Process;Production;promoter;protein degradation;protein purification;Proteins;Pseudomonas fragi;PTK2 gene;quorum sensing;Regulation;Reporter;Resistance;Role;Source;Staphylococcus aureus;System;Testing;Time;transcriptome sequencing;transcriptomics;uptake;Virulence Factors

PROJECT_TITLE: Characterization of the Staphylococcus aureus fatty acid degradation pathway