ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Biotechnology;Organ Transplantation;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Transplantation;Traumatic Head and Spine Injury

PHR: PROJECT NARRATIVE  The goal of this revised proposal is to purchase the Alinity ci analytical platform to equip a new Core service to be housed within the MGH Center for Transplantation Sciences. In addition to providing mission- critical support to multiple CTS users by measuring immunosuppressive drug levels in large animal ‘translational’ transplant models and in rodent transplant models, this platform will support translational scientific projects for multiple other research programs across the MGH research community (tissue engineering and regenerative medicine, housed within the Center for Engineering in Medicine and Surgery; trauma; cardiovascular medicine and surgery; neural science; Center for Comparative Medicine; Knight Surgical Research Laboratory). In addition, through the Shared Equipment mechanism this versatile, high- throughput assay platform will support future growth in new research directions via development of multiple new assay capabilities, and newly meet the needs of the rodent research community through small-volume assay capabilities.

PI_NAMEs: PIERSON, RICHARD N (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: Allogenic;Animals;assay development;base;Biochemical;Biological Assay;Cardiovascular system;cell injury;Cell Therapy;Cells;Chemistry;Clinical;Communities;Core Facility;Cost Savings;Custom;Cyclosporins;Diabetes Mellitus;Electrolytes;end of life;Equipment;Funding;Hospitals;Human;Immunosuppressive Agents;individualized medicine;Institution;Laboratories;Laboratory Animals;Metabolism;Mission;Modality;Mycophenolate;Organ;Organ Transplantation;Parkinson Disease;Plasma;prevent;Regenerative Medicine;Regimen;Research;Research Personnel;Research Project Grants;Resources;Rodent;Sampling;Science;Serum;Services;side effect;Sirolimus;Spinal cord injury;Tacrolimus;Therapeutic;Time;Tissue Grafts;Tissues;translational model;transplant centers;Transplantation;Transplantation Tolerance;Trauma;United States National Institutes of Health;Vendor;Virus;Work;Xenograft procedure

PROJECT_TITLE: Versatile high-throughput Alinity ci assay platform to support multiple laboratory animal users

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-D (30)]


ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The FACSDiscover S8 Image-Enabled Spectral Cell Sorter is a powerful, cutting-edge research instrument capable of identifying dozens of unique cell populations from biological samples using fluorescence and imaging measurements. These cell populations can then be isolated with extremely high purity and subsequently analyzed to provide a deeper and much needed understanding of a wide array of human diseases to help develop the treatments of tomorrow. Allowing such discoveries is the current roadblock addressed by this application, which is aimed at bringing a currently unavailable novel high-end technology at Columbia University for the betterment of human health.

PI_NAMEs: PASSEGUE, EMMANUELLE  (contact)

PROJECT_TERMS: Address;Aging;Area;Biomedical Engineering;Cancer Biology;Cells;Communities;Core Facility;Detection;Electrostatics;Flow Cytometry;Fluorescence;Funding;human disease;Image;Immunology;insight;Measurement;Medical;Medical center;Morphology;Nerve Degeneration;next generation;novel;Population;population based;real-time images;Research;Research Personnel;Resolution;Signal Transduction;Sorting;Speed;stem cells;Technology;Universities

PROJECT_TITLE: BD FACSDiscover S8 Image-Enabled Spectral Cell Sorter

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: Nashville

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Measuring changes in energy production and use at the cellular level is critical to understanding biology. The Seahorse XF Pro Analyzer provides an increased throughput method to measure key components of cellular metabolic functions in live cells, over time. Thus, the Seahorse can comprehensively advance our understanding of human health and disease biology.

PI_NAMEs: BAUER, JOSHUA A. (contact)

PROJECT_TERMS: Area;Bioenergetics;Biomedical Research;Cardiology;Cells;Computer software;Computers;Data;Data Analyses;Disease;Funding;Genus Hippocampus;high throughput screening;Hour;imaging system;Immunology;improved;instrument;interest;Life Expectancy;Malignant Neoplasms;Medical center;Metabolic dysfunction;Mitochondria;Modeling;multiplex assay;Neurodegenerative Disorders;Obesity;Organoids;Permeability;Publications;Research;Research Personnel;Sampling;Suspensions;Temperature;Time Study;Tissues;Translational Research;United States National Institutes of Health;Universities;Whole Organism

PROJECT_TITLE: Agilent Seahorse XF Pro Analyzer


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Orphan Drug;Precision Medicine;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE We propose biomarker-directed therapy for patients with HER2-amplified locally advanced rectal cancer. In a clinical trial and associated correlative studies (using tissue and blood samples, HER2-targeting 89Zr-trastuzumab PET/MRI scans, and patient-derived organoid models), we will evaluate the efficacy and biological effects of HER2-targeted induction therapy, alone and with standard-of-care chemotherapy, to treat HER2-amplified rectal cancer. This therapy has the potential to transform the care of this molecularly defined subset of rectal cancer, omit radiation and/or surgery, and avoid the morbidity of standard-of-care tri-modality therapy.

PI_NAMEs: CERCEK, ANDREA  (contact);YAEGER, RONA

PROGRAM_OFFICER_NAME: OLKHANUD, PUREVDORJ BALJINNYAM

PROJECT_TERMS: 3-Dimensional;Adjuvant Chemotherapy;arm;Biological;Biological Markers;Biology;biomarker driven;Biopsy;Biopsy Specimen;Blood;Blood specimen;Cancer Model;Caring;Cellular Structures;chemoradiation;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Trials;Collection;colon cancer patients;Colon Carcinoma;Colorectal Cancer;Colostomy Procedure;Combined Modality Therapy;Correlative Study;Data;Dependence;design;Dimerization;Disease;Distal;efficacy evaluation;Enrollment;ERBB2 gene;experience;fluoropyrimidine;Frequencies;Genetic Transcription;Goals;immune checkpoint blockade;Immune checkpoint inhibitor;improved;In complete remission;Incidence;Institutional Review Boards;Intestines;Magnetic Resonance Imaging;metastatic colorectal;Mismatch Repair Deficiency;Modality;Modeling;Molecular;Morbidity - disease rate;MRI Scans;Neoadjuvant Therapy;Operative Surgical Procedures;Organ;Organoids;Pathologic;Patient Selection;Patients;Pharmaceutical Preparations;pharmacodynamic biomarker;Phase;phase 2 study;Positron-Emission Tomography;Pre-Clinical Model;predicting response;Primary Neoplasm;programs;Progression-Free Survivals;Quality of life;Radiation;radiological imaging;Rectal Cancer;Recurrence;Regimen;Research;Research Personnel;Resistance;resistance mechanism;Resources;response;response biomarker;Sampling;Sexual Dysfunction;standard care;standard of care;success;targeted treatment;Testing;Tissue Sample;Tissues;Toxic effect;Trastuzumab;treatment optimization;tumor;tumor DNA;urinary

PROJECT_TITLE: Neoadjuvant Tucatinib plus Trastuzumab in HER2-amplified Locally Advanced Rectal Cancer

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Considering that over 80 million Americans live with obesity (2020 prevalence of body mass index ≥30 kg/m2 among adults was 41.9%), obesity is a major health problem in the United States. The 2021 Food and Drug Administration (FDA) approval of the glucagon-like peptide 1 (GLP-1) receptor agonist, semaglutide (Wegovy), as an anti-obesity medication (AOM) is ushering in a radical shift in the treatment of obesity and AOMs are poised to become an important tool in population weight management. We have yet to understand how best to implement AOMs equitably and effectively in everyday practice, so we will detail the current state of AOM prescribing and implementation and engage a diverse array of stakeholders to design tailored interventions that optimize AOM access across health care settings based on best practices.

PI_NAMEs: ARTERBURN, DAVID ERIC;MACIEJEWSKI, MATTHEW L (contact);SALES, ANNE EVELYN

PROGRAM_OFFICER_NAME: UNALP-ARIDA, AYNUR

PROJECT_TERMS: access disparities;Address;Adult;Affect;Agonist;American;Attitude;bariatric surgery;Behavior Therapy;Body mass index;Characteristics;Chronic Disease;Clinic;Clinical;clinical practice;Collaborations;Complement;Data;design;Development;Disparity;Drug Prescriptions;Economics;Eligibility Determination;Environment;Equity;Evaluation;GLP-I receptor;Goals;Health;Health Benefit;health care settings;Health Care Visit;Health Personnel;Health system;Hybrids;implementation context;implementation design;implementation intervention;implementation strategy;insight;Insurance Coverage;Intervention;Interview;Knowledge;Light;Low income;medication safety;Metabolic;multi-site trial;Obesity;obesity treatment;Patient Selection;Patients;Pattern;Pharmaceutical Preparations;Population;population health;Positioning Attribute;Prevalence;Process;Provider;Site;System;Testing;therapy design;Time;tool;trial design;Typology;Uninsured Medical Expense;United States;United States Food and Drug Administration;Update;uptake;Weight maintenance regimen;Work;Writing

PROJECT_TITLE: Developing robust anti-Obesity Medication ImplemeNtatiOn approaches to maximize population health (the DOMINO study)

STUDY_SECTION: SIHH

STUDY_SECTION_NAME: Science of Implementation in Health and Healthcare Study Section[SIHH]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: NOTRE DAME

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative Clostridioides difficile infections (CDIs) are difficult to treat, resulting in 11,500 deaths in the United States every year. A challenge in treating CDI is the production of spores that germinate to vegetative cells, which cause the infection. Recurrence of infection occurs in 25% of patients. There are no antibiotics for the treatment of recurrent CDI. CDI is the deadliest of the five bacterial urgent threats. Understanding the process of spore germination is key to elucidating the basis for recurrent CDI. If spore germination could be prevented, the nefarious cycles of CDI can be interrupted. We disclose the discovery of a new class of antibiotics (the oxadiazoles) that kill C. difficile in the growing phase (vegetative cells). We also have found that certain oxadiazoles also inhibit spore germination. Our goals are to elucidate the spore-germination pathway, to show that inhibition of spore germination can stop recurrence of infection, and to discover new and more effective oxadiazoles that inhibit spore germination.

PI_NAMEs: CHANG, MAYLAND F (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Anti-Bacterial Agents;Antibiotic Therapy;Antibiotics;Applications Grants;bactericide;Bile Acids;Binding;Calorimetry;Cell Wall;Cells;Cessation of life;Clostridium difficile;Collaborations;cytotoxicity;Drug Kinetics;dysbiosis;Evaluation;Event;Exhibits;experimental study;falls;Family;gene cloning;Germination;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;gut bacteria;gut colonization;gut microbiota;Hamsters;In Vitro;in vitro Model;in vivo;Infection;Interruption;Intervention;Knock-out;lead optimization;Ligands;liquid chromatography mass spectrometry;Modeling;Mus;mutant;novel antibiotic class;Oxadiazoles;Pathway interactions;Patients;Peptidoglycan;pharmacologic;Phase;prevent;Process;Production;protein function;Proteins;prototype;Reaction;Recurrence;recurrent infection;Reproduction spores;Resistance;Resolution;response;Roentgen Rays;Spain;Structure;Surface Plasmon Resonance;Time;Titrations;United States

PROJECT_TITLE: Spore germination pathway in Clostridioides difficile and its pharmacological intervention

STUDY_SECTION: AIRT

STUDY_SECTION_NAME: Anti-Infective Resistance and Targets Study Section [AIRT]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: ROCHESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative Microglia are immune cells that act as the primary rst-responding sentinels in the brain. Although direct comparisons between microglia morphology and function are hard to make, it is clear that morphology changes in response to many diseases. Improved methods of microglia image processing and analysis are needed to directly link morphological changes with their corresponding functional consequences in models of many human disease processes.

PI_NAMEs: MCCALL, MATTHEW NICHOLSON (contact);THURSTON, SALLY W

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Algorithms;Area;Back;biomedical imaging;Biometry;Brain;brain tissue;Cells;Cellular Morphology;Communities;Computer software;Confocal Microscopy;Data;data repository;data standards;Dependence;Development;digital imaging;Disease;Environmental Exposure;Exposure to;Fractals;Genetic Diseases;Genetic Models;Genomics;Genotype;Goals;Grouping;Homeostasis;human disease;Image;Image Analysis;image processing;Immune;immune function;improved;Individual;Infection;Investigation;Link;Measures;Medicine;Methodology;Methods;Microglia;microscopic imaging;Modeling;Morphology;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;neuroinflammation;neuronal cell body;Neurons;Neurosciences;open source;Outcome;Parameter Estimation;Pathology;Physiological;Pregnancy;Process;Reaction;Research;Research Methodology;Resolution;Resources;response;response to brain injury;Role;Sentinel;Series;Shapes;Statistical Methods;Statistical Models;statistics;Stereotyping;Stimulus;Synaptic plasticity;Toxic Environmental Substances;toxicant;Toxicant exposure;Uncertainty;Work

PROJECT_TITLE: Statistical Methods for Confocal Microscopy Images of Microglia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Contraception/Reproduction;Heart Disease;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Women's Health Research

ORG_CITY: PROVIDENCE

ORG_NAME: MIRIAM HOSPITAL

ORG_STATE: RI

PHR: NARRATIVE Hypertensive disorders of pregnancy are a leading cause of maternal morbidity and mortality in the United States. Women and offspring exposed to hypertensive disorders prenatally face significant lifetime cardiovascular disease risk. The goal of this ancillary study is to test the enduring effects of a prenatal mindfulness training intervention, conducted in the parent RCT, on postpartum markers of maternal and infant cardiovascular disease risk.

PI_NAMEs: BUBLITZ, MARGARET  (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Address;Adult;Affect;Ancillary Study;behavioral health;Biological Markers;Biometry;Birth;Blood;Blood Pressure;blood pressure reduction;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cholesterol;Clinical Research;Disease;Ecological momentary assessment;Educational Intervention;Educational process of instructing;Enrollment;ethnic diversity;experience;Exposure to;Face;Financial cost;Goals;Growth;Healthcare Systems;Heart;heart disease prevention;Heart Diseases;heart rate variability;Hematological Disease;High birth weight infant;High Risk Woman;Hour;Hypertension;improved;in utero;Infant;Inflammation;Insulin Resistance;interest;Intervention;Intervention Studies;Knowledge;Length;Life;lifetime risk;Long-Term Effects;Lung;Lung Diseases;maternal morbidity;Maternal Mortality;maternal risk;Maternal-fetal medicine;Measures;Medical;Mind-Body Intervention;mindfulness intervention;Mindfulness Training;Mothers;National Heart, Lung, and Blood Institute;Nonpharmacologic Therapy;novel therapeutic intervention;obstetrical complication;offspring;Outcome;Parents;Participant;participant enrollment;participant retention;Pediatrics;perinatal period;Physiological;postnatal period;Postpartum Period;Pregnancy;pregnancy disorder;pregnancy related death;prehypertension;prenatal;prenatal disorder;prevent;Prevention;preventive intervention;Process;psychologic;racial diversity;Randomized;rapid weight gain;recruit;Regulation;Reporting;response;Risk;Risk Reduction;Sampling;Sleep;Social support;stress management;Testing;Time;treatment as usual;Triglycerides;United States;Weight;Woman

PROJECT_TITLE: Mechanisms of mindfulness training to reduce maternal and infant cardiovascular disease risk

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: NARRATIVE Funds are requested to replace a legacy confocal microscope with a Leica Stellaris 8 Falcon microscope to provide state-of-the-art multiplexed high-resolution imaging capability to a cross-departmental user group at Massachusetts General Hospital. This resource will support NIH-funded projects with the potential to uncover new ways to treat a wide range of human diseases including cancer, neurodegeneration, fibrotic disease, as well as allergy and asthma.

PI_NAMEs: MEMPEL, THORSTEN ROMAN (contact)

PROJECT_TERMS: Aging;base;Biology;Biomedical Research;Cancer Center;Cardiology;Color;Communicable Diseases;Communities;Dedications;Detection;detection platform;detection sensitivity;detector;Disease;Endowment;Equipment;flexibility;fluorescence lifetime imaging;Fluorochrome;Funding;General Hospitals;high resolution imaging;image reconstruction;imaging capabilities;imaging facilities;imaging modality;imaging platform;Imaging technology;Immunology;Individual;Inflammatory;insight;Institution;instrument;interest;Laboratories;Lasers;Light;Manufacturer;Massachusetts;Microscope;microscopic imaging;Microscopy;Modality;Modernization;Molecular;multi-photon;Nephrology;Neurology;Operative Surgical Procedures;Pathology;Physiologic pulse;Pulmonology;Research;Research Personnel;Research Project Grants;response;Slide;spectrograph;System;Systems Biology;Technology;Time;Tissues;Transplantation;ultra high resolution;United States National Institutes of Health

PROJECT_TITLE: Leica Stellaris 8 Falcon confocal microscope

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


PHR: PROJECT NARRATIVE All functional Magnetic Resonance Imaging (fMRI) methods in use today measure human brain activity by tracking the associated changes in blood flow, volume, and oxygenation, and recent evidence suggests that these hemodynamic changes are controlled at a fine enough scale to permit localizing neuronal activity to the individual layers of the cerebral cortex, which would enable investigations of brain circuitry. Unfortunately, most fMRI methods lack the imaging resolution to detect these hemodynamic responses within cortical layers, which have a thickness of only a few hundreds of micrometers. To address this, here we will develop new tools using “line-scan” imaging to enable human fMRI with extremely high resolution in just one direction, perpendicular to the cortical layers, along with several technical advancements to make these tools reliable and widely usable, and then apply them to several investigations seeking to map out brain circuitry in healthy volunteers.

PI_NAMEs: POLIMENI, JONATHAN RIZZO (contact)

PROGRAM_OFFICER_NAME: BABCOCK, DEBRA J

PROJECT_TERMS: Address;Adopted;Area;area striata;Biophysics;Blood flow;blood oxygenation level dependent response;Blood Vessels;Brain;brain circuitry;Brain Mapping;capillary bed;Cerebral cortex;Characteristics;Communication;Contralateral;Data;data acquisition;data dissemination;Dependence;Experimental Designs;Feedback;Fingers;Functional Magnetic Resonance Imaging;functional MRI scan;healthy volunteer;hemodynamics;Human;Image;imaging modality;Individual;insight;interest;Investigation;Ipsilateral;Left;Location;Magnetic Resonance Imaging;Manuals;Maps;Measurement;Measures;meter;Methods;Morphologic artifacts;Motion;Motor Cortex;MRI Scans;Neurons;Noise;novel;Outcome;Output;Pathway interactions;Pattern;Physiologic pulse;Physiological;Pial Veins;Positioning Attribute;prospective;Radial;radio frequency;Reaction Time;Resolution;response;Rest;Sampling;Scanning;Sensitivity and Specificity;Signal Transduction;simulation;Slice;spatiotemporal;Specific qualifier value;Specificity;Surface;Technology;temporal measurement;Testing;Thick;Time;tool;Touch sensation;usability;Veins;Visual;Visual Cortex

PROJECT_TITLE: Resolving Human Brain Activation Across Cerebral Cortical Layers with Line-Scan Functional MRI

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Breast Cancer;Cancer;HIV/AIDS;Neurodegenerative;Women's Health Research

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative: A Beckman Optima AUC analytical ultracentrifuge is requested by the Center for Biomolecular Structure and Dynamics at the University of Montana in Missoula to support NIH-funded biomedical research, The instrument will provide high resolution hydrodynamic and optical characterization of biological macromolecules and their assemblies, The information gained is critical for the study of human disease and cancer, development of new drugs and vaccines, and to further the understanding of molecular processes occurring in the cell.

PI_NAMEs: DEMELER, BORRIES  (contact)

PROJECT_TERMS: absorption;Address;Algorithms;Amyloid beta-Protein;analytical ultracentrifugation;Antibiotics;Bacterial DNA;Basic Science;biophysical properties;chromatin remodeling;Computer software;Data;Detection;Development;Disease;drug development;experimental study;Extramural Activities;Funding;gene therapy;Germ Cells;HIV;hydrodynamic model;improved;innovation;Institution;instrument;instrumentation;lipid nanoparticle;Malignant Breast Neoplasm;manufacture;Manuscripts;Measurement;method development;Modeling;Montana;Natural Immunity;Neurodegenerative Disorders;Noise;Opioid;Phase;protein structure;Proteins;Publishing;receptor binding;Reproducibility;Research;Research Institute;Research Personnel;Research Project Grants;Research Support;Scanning;Science;Signal Transduction;software development;stoichiometry;Structure;System;Testing;Thermodynamics;Training;United States National Institutes of Health;Universities;vaccine development

PROJECT_TITLE: Acquisition of a Beckman-Coulter Optima AUC Analytical Ultracentrifuge for the University of Montana


ADMINISTERING_IC: GM

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Telomeric DNA synthesis is the cornerstone of telomere maintenance, which, if deregulated, leads to human diseases such as cancer and premature aging. While the mechanism of the initial part of telomeric DNA synthesis – telomere G-overhang extension by telomerase – is well understood, the subsequent telomere C- strand fill-in process is much less known. This proposal seeks to establish how the human telomere C-strand fill-in machinery assembles at telomeric G-overhangs and builds the complementary C-strand.

PI_NAMEs: LIM, CI JI  (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Address;Area;Binding;Biochemical;Biochemistry;Biophysics;C-terminal;Catalytic RNA;Chromosome abnormality;Chromosomes;Complex;Computing Methodologies;Consensus;Coupled;Cryoelectron Microscopy;Dinucleoside Phosphates;DNA;DNA biosynthesis;DNA polymerase alpha-primase;DNA Primase;DNA Primers;DNA-Directed DNA Polymerase;DNA-Protein Interaction;Docking;ds-DNA;Dyskeratosis Congenita;Elements;Eukaryotic Cell;Failure;flexibility;genome integrity;Genome Stability;Genomic Instability;Goals;Hand;Human;human disease;insight;interdisciplinary approach;Investigation;Knowledge;Length;Malignant Neoplasms;Maps;Modeling;Molecular;molecular dynamics;Mutagenesis;Mutation;novel;Nucleoproteins;Nucleotides;particle;physical model;Physical Restraint;Play;Polymerase;Positioning Attribute;Premature aging syndrome;Process;protein complex;Proteins;Reaction;Recombinants;reconstitution;Reporting;Research;Ribonucleoproteins;RNA;RNA chemical synthesis;RNA primers;Role;Single-Stranded DNA;Specificity;SS DNA BP;structural biology;Structural Models;Structure;Structure-Activity Relationship;Study models;Tandem Repeat Sequences;Telomerase;telomere;Telomere Maintenance;Telomere Shortening;Testing;Validation;Work

PROJECT_TITLE: Mechanism of the Human Telomere C-Strand Fill-In Machinery Assembly and Activation at Chromosome Ends

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Neurosciences;Sleep Research

ORG_DEPT: NEUROSCIENCES

ORG_NAME: TUFTS UNIVERSITY BOSTON

PHR: Project Narrative There is still much to be learned about how glial astrocytes and neuronal populations of the brain communicate to regulate complex behavior. We have identified transgenic strains that drive expression in specific astrocyte subpopulations and used them to define subpopulations relevant for sleep or circadian behavior. We will utilize these strains to define mechanisms of communication between the two cell types that mediate regulation of rhythmic behaviors.

PI_NAMEs: JACKSON, F ROB  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Activity Cycles;Address;Adult;Arousal;Astrocytes;Behavior;Behavioral;Brain;Cell Communication;cell type;Cells;cellular imaging;cellular targeting;circadian;circadian pacemaker;circadian regulation;Circadian Rhythms;Clock protein;Communication;Complex;Cyclic AMP;Data;Dorsal;Drosophila genus;Enhancers;experience;fly;Genes;Genetic;genome-wide;Homeostasis;Human;Insecta;knock-down;Learning;Link;Mammals;Measures;Mechanics;Mediating;Methods;Molecular;Molecular Profiling;Nervous System Disorder;neural;neural patterning;neurodevelopment;Neuroglia;Neurons;neurotransmission;Output;Pathologic;Pathway interactions;Periodicity;Phylogenetic Analysis;Physiological;Physiology;Pigments;Population;pressure;Process;promoter;Property;Protocols documentation;Publishing;reconstitution;Regulation;Reporter;response;Role;Second Messenger Systems;sensor;Serine;Signal Pathway;Signal Transduction;Signaling Molecule;Sleep;Sleep Deprivation;sleep physiology;sleep regulation;Synapses;System;Taxonomy;Techniques;Testing;tool;transcriptomic profiling;Transgenic Organisms;translating ribosome affinity purification and RNA-sequencing;Visualization

PROJECT_TITLE: Glia-Neuron Communication Regulating Rhythmic Behaviors

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Astroviruses are a global cause of gastroenteritis, commonly known as stomach flu, but currently there are no vaccines or treatments available to protect against these viruses. Identifying which human factors these viruses subvert to infect the intestine is critical for the generation of much-needed tools to study astroviruses in cell culture and in animal models. Defining these factors will also reveal key targets for novel antiviral therapies to prevent infection.

PI_NAMEs: BALDRIDGE, MEGAN T (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: adaptive immune response;Affect;Amino Acids;Animal Model;Anti-viral Agents;Anti-viral Therapy;Antibodies;Astrovirus;Binding;Biology;biophysical analysis;Caco-2 Cells;Capsid;Cell Culture Techniques;cell immortalization;Cell Line;Cells;Childhood;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Colon Adenocarcinoma;combat;Complementary DNA;Coronavirus Infections;CRISPR screen;CRISPR-mediated transcriptional activation;Cryoelectron Microscopy;Data;Development;Dipeptidyl Peptidases;Dipeptidyl-Peptidase IV;Echo Viruses;Echovirus Infections;Ectopic Expression;Encephalitis;Fc Receptor;FDA approved;fighting;flu;Foundations;Future;Gastroenteritis;Gene Knock-Out Model;Generations;Genes;genetic analysis;genome-wide;Goals;Human;human model;Immune response;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;Infection prevention;inhibitor;innate immune pathways;Innate Immune Response;insight;Integration Host Factors;Interferometry;Intestines;Knock-in;Knock-out;Knowledge;Maps;Mediating;Meningitis;Middle East Respiratory Syndrome Coronavirus;Modeling;Molecular;mortality;mouse model;Mus;neonatal Fc receptor;Norovirus;novel;overexpression;Pathogenesis;permissiveness;pharmacologic;Physiological;Preclinical Testing;Proteins;receptor;receptor binding;receptor expression;receptor function;Research;Resolution;reverse genetics;RNA Viruses;Role;Rotavirus;screening;Seroprevalences;Species Specificity;Stomach;Structure;System;Techniques;Technology;Tertiary Protein Structure;Testing;tool;Transgenic Organisms;Tropism;vaccine evaluation;Vaccines;Viral;Viral Gastroenteritis;Virion;Virus;Virus Diseases;virus host interaction;Virus Receptors

PROJECT_TITLE: Structural and functional definition of human astrovirus-receptor interactions

STUDY_SECTION: VDT

STUDY_SECTION_NAME: Viral Dynamics and Transmission Study Section [VDT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Newark

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative This application proposes to purchase a high-end mass spectrometer to support a strong cohort of NIH-funded researchers at Rutgers University and nearby institutions. This new instrument allows Rutgers Newark researchers and collaborators to speed up their biomedical research by detecting more proteins in cells and diseased tissues. Thus, adding this instrument to Rutgers Center for Advanced Proteomics Research is critical in improving our research productivity and the capacity to remedy human diseases, including infections, cancer, heart ailments, and brain diseases.

PI_NAMEs: LI, HONG  (contact)

PROJECT_TERMS: Acceleration;Awareness;Computer software;Coupled;empowerment;Engineering;Equipment;exhaust;experience;Funding;Gases;Goals;Grant;Health Sciences;High Pressure Liquid Chromatography;improved;Institution;instrument;instrumentation;Investigation;ion mobility;ion source;Ions;Isomerism;mass analyzer;mass spectrometer;medical schools;New Jersey;Peptides;Performance;Positioning Attribute;Post-Translational Protein Processing;Proteome;Proteomics;Request for Proposals;Research;Research Personnel;Resolution;Sampling;Scientist;Services;Spectrometry;Speed;Technology;Time;United States National Institutes of Health;Universities;Wait Time

PROJECT_TITLE: Bruker timsTOF HT Mass Spectrometer for Accelerating Proteomics Research at Rutgers Newark Campus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MBBC-T (30)]


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS

ORG_CITY: VALHALLA

ORG_NAME: NEW YORK MEDICAL COLLEGE

PHR: PROJECT NARRATIVE This is a shared instrumentation grant for a protein analysis system that may quantitative and reproducible results as the most essential core piece of equipment for their current and future research. This is a critical state of the protein analysis system for investigators at NYMC, who while experienced with protein analysis and molecular biology, currently have no access to proteomics core. The ProteinSimple Jess System is automated, sensitive, and creates electronic data files that are impervious to manipulation, as it contains the raw and analyzed data, which can easily be uploaded to a data repository when it comes time to publish, thus, meeting established guidelines on NIH’s reproducibility and rigor.

PI_NAMEs: OKEOMA, CHIOMA M (contact)

PROJECT_TERMS: Agreement;Antibodies;Automation;Biological Assay;Biomedical Research;Cells;college;Data;Data Files;data repository;Dedications;detection platform;Discipline;electronic data;Equipment;extracellular;extracellular vesicles;Funding;Future;Gene Expression Profiling;Guidelines;Histologic;Image;improved;Incubated;instrument;Laboratories;medical schools;meetings;Minor;Molecular Weight;nanoimmunoassay;New York;Noise;particle;Physical condensation;Protein Analysis;Proteins;Proteomics;Publishing;Reproducibility;Reproducibility of Results;Research;research facility;Research Personnel;Sampling;Signal Transduction;Source;Strategic Planning;Surveys;System;Systems Analysis;Time;Tissues;United States National Institutes of Health;Western Blotting

PROJECT_TITLE: ProteinSimple Jess System for Protein Analysis at NYMC


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Substance Misuse

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Alcohol use disorder (AUD) affects approximately 14.1 million people in the United States. Despite the prevalence of this disorder, we lack a thorough understanding of its underlying neurobiological mechanisms. Here, we propose to use a multi-faceted approach integrating machine learning based behavioral analysis, cell type specific genetic manipulations, in vivo imaging and ex vivo slice physiology to begin to unravel the role of PVNCRH neurons in alcohol use disorders.

PI_NAMEs: BAINS, JAIDEEP ;KASH, THOMAS L. (contact)

PROGRAM_OFFICER_NAME: LIU, QI-YING

PROJECT_TERMS: Abstinence;Acute;Adrenal hormone preparation;Affect;alcohol availability;alcohol behavior;alcohol consequences;Alcohol consumption;alcohol exposure;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Automobile Driving;Behavior;Behavioral;biophysical properties;cell type;Cells;Chronic;chronic alcohol ingestion;Complex;Corticotropin-Releasing Hormone;Coupled;Data;Desire for food;Development;Disease;drinking behavior;Endocrine;Endoscopes;Ethanol;Exhibits;experimental study;Female;flexibility;Genetic;genetic approach;genetic manipulation;Glutamates;Grooming;Homeostasis;Hormonal;Hormones;Hydrocortisone;Hyperactivity;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;in vivo imaging;Ion Channel;Lateral;Link;Long-Term Effects;Machine Learning;male;Mediating;Mus;neural;neurobiological mechanism;neuronal excitability;Neurons;optogenetics;Output;paraventricular nucleus;Pathway interactions;Pattern;Persons;Physiological;Physiology;Pituitary Gland;Play;Population;Prevalence;Production;Property;Recording of previous events;response;Role;sex;Shapes;Signal Transduction;Slice;social;Stimulus;Stress;stressor;synaptic function;System;Testing;Time;transmission process;United States;Withdrawal;Work

PROJECT_TITLE: Probing Ethanol Dysregulation of Hypothalamic CRH neurons

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Heart Disease;Lung;Networking and Information Technology R&D (NITRD);Pulmonary Hypertension

PHR: Project Narrative One of the heart’s two main pumping chambers, the right ventricle, sometimes fails and causes severe illness. The health of this heart chamber is difficult to monitor and treat, problems we aim to address with new ways to analyze a patient’s data. For patients with right heart failure our goal is to improve their chance of survival and shorten their time in intensive care.

PI_NAMEs: HOUSTIS, NICHOLAS E. (contact)

PROGRAM_OFFICER_NAME: FARAHANI, KEYVAN

PROJECT_TERMS: Ablation;Address;Algorithms;Awareness;Biological Assay;Cardiac Catheterization Procedures;Cardiac health;Cardiac Surgery procedures;Cardiology;Cardiovascular Diseases;Cardiovascular Models;Cardiovascular Physiology;Cardiovascular system;Clinical;Clinical Data;comorbidity;Complex;Computer Models;computerized tools;computing resources;Coupling;Critical Care;Data;Data Set;data streams;Databases;Diagnosis;Differential Equation;digital;digital twin;Electronic Health Record;Environment;experience;Face;Goals;Heart;Heart Transplantation;hemodynamics;Hybrids;Impairment;improved;in silico;Inpatients;Intensive Care;Intensive Care Units;Intuition;Knowledge;Learning;left ventricular assist device;Left ventricular structure;Liquid substance;Measurement;Measures;Methodology;Modeling;Monitor;neural network;Outpatients;Output;Patient-Focused Outcomes;Patients;Pharmacotherapy;Physicians;Physiology;Population;Postoperative Period;predict clinical outcome;Predisposition;pressure;Property;Psyche structure;Pulmonary artery structure;Pulmonary Hypertension;Pump;Recovery;Relaxation;Rest;Resuscitation;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Right ventricular structure;sensor;stem;System;Techniques;Technology;Testing;Time;tool;Twin Multiple Birth;United States National Aeronautics and Space Administration;Update;Vasodilator Agents;Ventricular;Ventricular Tachycardia

PROJECT_TITLE: A Digital Hemodynamic Twin for Right Ventricular Dysfunction

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lymphatic Research;Microbiome;Prevention;Skin Cancer

ORG_CITY: HOUSTON

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Melanoma is a deadly skin cancer that kills thousands of people in the US each year, despite revolutionary treatments such as immunotherapy; more forms of treatment are needed to improve outcomes for patients with advanced melanoma and to keep melanoma from spreading in patients with early-stage disease. Our group previously demonstrated that bacteria in the gut influence response to immunotherapy and showed that modifying these bacteria can improve treatment responses in patients with advanced melanoma. We will now study the impact of gut microbes in early-stage melanoma, with the goal of developing next-generation therapeutic strategies to better treat, intercept, and ultimately prevent melanoma.

PI_NAMEs: HOLDER, ASHLEY M;LUND, AMANDA W.;WARGO, JENNIFER A. (contact)

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Age;Bacteria;beta diversity;Blood Vessels;BRAF gene;Clinical;Clostridiaceae;Correlation Studies;Cutaneous Melanoma;Data;Dermis;Development;digital;Disease;Disease Progression;Distal;Distant;Distant Metastasis;draining lymph node;dysbiosis;Epidermis;Evolution;fecal transplantation;Feces;Funding Mechanisms;Future;Genes;Genetic Transcription;Goals;Grant;gut bacteria;gut microbes;gut microbiome;gut microbiota;high risk;Immune;immune checkpoint blockade;Immunity;Immunologic Surveillance;Immunologics;immunoregulation;Immunotherapy;Impairment;Implant;improved;improved outcome;Infiltration;innovation;Intercept;Intervention;Invaded;Knowledge;lymph node microenvironment;Lymph Node Tissue;lymph nodes;lymphatic vessel;Malignant Neoplasms;Melanoma;Melanoma patient;Melanoma Tumor;metagenomic sequencing;Metastatic Melanoma;Metastatic Neoplasm to Lymph Nodes;Microbe;microbial;microbiome;microbiota;Modeling;mouse model;Mutation;Neoadjuvant Therapy;Neoplasm Metastasis;next generation;novel;novel therapeutic intervention;novel therapeutics;Pathway interactions;Patient-Focused Outcomes;Patients;Peripheral;Persons;Pre-Clinical Model;prevent;Primary Neoplasm;Prognostic Factor;Relapse;responders and non-responders;response;Risk;Seminal;Sentinel Lymph Node;sex;Site;Skin;Skin Cancer;stool sample;Systemic disease;targeted treatment;Testing;therapeutic target;Tissues;transcriptome sequencing;treatment response;tumor;Tumor Immunity;tumor progression;Tumor stage;tumor-immune system interactions;VEGFC gene;Work

PROJECT_TITLE: Targeting the gut microbiome to inhibit melanoma lymph node metastases

STUDY_SECTION: CPSS

STUDY_SECTION_NAME: Cancer Prevention Study Section[CPSS]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Protein identification and quantification (ie., bottom-up proteomics) using high mass accuracy mass spectrometry is dependent on the ability to separate peptides using liquid chromatography (HPLC) prior to mass spectrometry. The requested Vaquish Neo UHPLC will provide a necessary upgrade to the current HPLC, which will no longer be serviceable due to age, for the Mass Spectrometry and Proteomics Core of The Wertheim UF Scripps Institute. As a bundled system with a current high mass accuracy mass specrometer, this instrument will will continue to be a campus-wide shared resource that will play a significant role in accelerating the biomedical applications and science for major and minor users, and for future researchers in neighboring institutions and counties.

PI_NAMEs: TSAPRAILIS, GEORGE  (contact)

PROJECT_TERMS: Address;Advisory Committees;Agreement;Blood capillaries;Child;Communities;Core Facility;Coupled;Disease;Doctor of Philosophy;Drug abuse;Ensure;Financial Support;Florida;Funding;Grant;High Pressure Liquid Chromatography;HIV Infections;innovation;Institution;instrument;Investigation;Jupiter;Liquid Chromatography;manufacture;mass spectrometer;mass spectrometry shared resource;Mass Spectrum Analysis;Medical Research;Minor;nano;Neurodegenerative Disorders;neuropsychiatric disorder;next generation;Peptides;Proteome;Proteomics;Reproducibility;Research;Research Assistant;Research Institute;Research Personnel;Research Project Grants;Resources;Scientist;Services;Structure;System;Technology;United States National Institutes of Health;Universities;Wages

PROJECT_TITLE: Vanquish Neo UHPLC for The Wertheim UF Scripps Institute


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Congenital Heart Disease;Genetics;Heart Disease;Patient Safety;Pediatric;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: Murray

ORG_NAME: IHC HEALTH SERVICES, INC.

ORG_STATE: UT

PHR: PROJECT NARRATIVE This project will examine mitral valve prolapse and co-occurring morbidities to enhance the clinical identification and treatment of cardiac valve diseases in people with risk factors that may result in poor cardiovascular health outcomes. Specifically, the project will describe the natural history of valve disease and resulting major adverse health events among people with mitral valve prolapse and a range of potentially complicating factors and will assemble that information to derive feasible multivariable methods for stratifying risk. The knowledge produced by this project will inform future public health initiatives and clinical care processes that aim to promote the healthiest possible outcomes in people with underlying mitral valve disease.

PI_NAMEs: MAY, HEIDI THOMAS (contact);WHISENANT, BRIAN K

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Atrial Fibrillation;calcification;Cardiac;cardiac magnetic resonance imaging;Cardiovascular Diseases;cardiovascular health;Cardiovascular system;Cessation of life;Characteristics;Chest;Classification;Clinic;Clinical;clinical care;clinical development;clinical diagnosis;clinical diagnostics;clinical risk;clinical subtypes;Code;Collagen;Colorado;Congenital Disorders;Coupled;Data;Data Collection;data warehouse;Diagnosis;Diagnostic;diagnostic criteria;Disease;Disease Clusterings;disease diagnosis;Disease Progression;disorder subtype;Early Diagnosis;Early treatment;Echocardiography;EFRAC;Electronic Health Record;electronic structure;Electronics;empowerment;Enrollment;Epidemic;Equation;Evaluation;Event;Family;Fibrosis;First Degree Relative;follow-up;Foundations;Future;Genealogy;General Population;Genetic;genetic analysis;genetic association;genetic pedigree;Genetic Risk;genetic testing;genome-wide;Health;health care service;Health system;Healthcare Systems;Heart Atrium;Heart failure;Heart Valve Diseases;Heritability;Hospitals;Idaho;Image;imaging modality;Incidence;Individual;Infection;Inherited;innovation;International Classification of Disease Codes;Intervention;Joints;Kansas;Knowledge;Left ventricular structure;Link;Medical;Methods;Mitral Valve;Mitral Valve Insufficiency;Mitral Valve Prolapse;Modeling;Montana;Morbidity - disease rate;Morphology;mortality risk;Natural History;Nevada;Nomograms;novel;Operative Surgical Procedures;Outcome;papillary muscle;Participant;patient registry;patient stratification;Patients;personalized care;personalized medicine;Persons;Phenotype;point of care;polygenic risk score;poor health outcome;Population;Population Database;Population-Based Registry;Populations at Risk;predictive tools;preservation;Prevalence;Procedures;Process;Public Health;Pulmonary Hypertension;Recording of previous events;Registries;Reporting;Rheumatic Fever;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;risk stratification;Rural Health;Sampling;Services;Severities;Standardization;Structural defect;sudden cardiac death;Sudden Death;Tissues;tool;Update;Utah;Vascular Diseases;Ventricular Arrhythmia;Work;Wyoming;X-Ray Computed Tomography

PROJECT_TITLE: Impact of Advanced Imaging and Enhanced Risk Profiling on Mitral Valve Prolapse


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative We are requesting a light sheet microscope to perform high speed, multi-view volumetric imaging of live and optically cleared samples. The microscope will be incorporated into the MicRoN core at Harvard Medical School, where it will be accessible to many researchers to enhance their biomedical research and enable new discoveries.

PI_NAMEs: MONTERO LLOPIS, PAULA DE LA MILAGROSA (contact)

PROJECT_TERMS: Area;Biomedical Research;Cell Communication;Cell Physiology;Development;Developmental Biology;equilibration disorder;flexibility;frontier;Funding;gene therapy;Hearing problem;Image;Immune;instrument;Light;live cell imaging;medical schools;Methods;Microscope;Microscopy;model organism;Neurodevelopmental Disorder;Optics;Organ;Organism;Organoids;Pathogenesis;Phenotype;Phototoxicity;Physiological;Request for Proposals;Research Personnel;Resources;Sampling;Solvents;Speed;Structure;Thick;Tissue Sample;Tissues;tool;two-dimensional;Water;Zebrafish

PROJECT_TITLE: Light Sheet Microscope for Multi-View Imaging of Living and Optically Cleared Samples


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Digestive Diseases;Esophageal Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Relevance to public health This project will develop a non-destructive assay for prognostication of patients with Barrett’s esophagus based on machine-learning analysis of 3D pathology datasets of endoscopic biopsies. This project will demonstrate that computational 3D pathology is superior to existing 2D pathology methods for risk stratification of Barrett’s esophagus biopsy specimens, and especially for distinguishing between aggressive and indolent dysplasias (pre-cancer). Therefore, this project has value for guiding critical treatment decisions by gastroenterologists and patients.

PI_NAMEs: GRADY, WILLIAM MALLORY;LIU, JONATHAN T.C. (contact);MAHMOOD, FAISAL

PROGRAM_OFFICER_NAME: RAVICHANDRAN, VEERASAMY

PROJECT_TERMS: 3-Dimensional;Adoption;Algorithms;analog;Barrett Esophagus;Benchmarking;Biological Assay;Biological Markers;Biopsy;Biopsy Specimen;Cancer Center;Categories;cellular imaging;Chronic;Clinical;clinical decision support;Computational algorithm;computerized data processing;computerized tools;Computing Methodologies;Data;Data Set;deep learning;deep learning algorithm;Detection;Development;Diagnosis;Diagnostic;Dysplasia;Endoscopic Biopsy;Esophageal Adenocarcinoma;Esophagus;Excision;Forcep;Gastroenterologist;Gastroesophageal reflux disease;Generations;Goals;Health Expenditures;High grade dysplasia;high risk;Histology;Histopathology;Hospitals;iatrogenic injury;Image;improved;Incidence;individualized medicine;Indolent;Industry;Label;learning classifier;Lesion;Machine Learning;Malignant Neoplasms;Methods;Microscope;Microscopy;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Neoplasms;novel;Outcome;overtreatment;Pathologic;Pathologist;Pathology;Patient-Focused Outcomes;Patients;Performance;Periodicals;Play;Population;premalignant;preservation;Prevalence;prognostic;Prognostic Marker;prognostication;Prospective cohort;Public Health;Publishing;Quality Control;Recommendation;Reproducibility;Risk;Risk Assessment;risk stratification;Role;screening;Section 8;Series;side effect;Specimen;Stains;Standardization;Structure;success;Technology;Thinness;Three-dimensional analysis;Time;tissue archive;Tissue Sample;Tissues;TP53 gene;Training;treatment and outcome;Triage;Validation;Visualization;Washington;Woman;Workload

PROJECT_TITLE: Computational 3D pathology for Barrett's esophagus risk stratification

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative This proposal describes a request for a confocal microscope to be managed in an imaging core facility at Cornell University. The microscope will support a diverse group of NIH-funded researchers investigating a broad spectrum of biological and biomedical projects, ranging from gene regulation at the single molecule level to gut development, breast cancer and heart disease.

PI_NAMEs: WILLIAMS, REBECCA M (contact)

PROJECT_TERMS: 13 year old;Biotechnology;data management;Detection;Doctor of Philosophy;Ensure;fluorophore;Funding;Image;imaging facilities;Infrastructure;Microscope;multi-photon;Optics;programs;repaired;Request for Proposals;Research;Research Personnel;Resolution;Resources;Route;Sampling;Schedule;Scientist;Source;System;Training;United States National Institutes of Health

PROJECT_TITLE: Confocal microscope for Cornell BRC Imaging Facility


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: NARRATIVE This proposed “Research Supplement to Promote Diversity in Health-Related Research” builds on the activities of the parent grant (R01-MH128198: the Aging, Transitions over the Life course, and Suicide (ATLAS) Project), to examine psychosocial risk and protective factors for suicide mortality and suicidal behavior within the Black population. This supplement supports a comprehensive mentoring and career development plan for the candidate, Eskira Kahsay, to guide her through the completion of her doctoral training and successful launch of her academic research career. This mentoring plan leverages long-standing partnerships with the Program for Research on Black Americans (PRBA) and the Michigan Center for Urban African American Aging Research (MCUAAAR), which collectively provide an ideal environment for supporting the professional development, team mentorship, and research activities of early-career investigators working in minority mental health.

PI_NAMEs: MEZUK, BRIANA  (contact);ZIVIN, KARA

PROGRAM_OFFICER_NAME: LYONS, ELIZABETH ANNE

PROJECT_TERMS: access restrictions;Address;Adolescent;Adolescent and Young Adult;Adult;African American;Age;aged;Aging;Air;Alaska Native;American;American Indian Population;Area;Belief;Biometry;Black American;black men;Black Populations;Black race;black women;career;career development;career networking;causal model;Cause of Death;Cessation of life;Characteristics;classification trees;college;commune;Community Surveys;completed suicide;contextual factors;Coping Behavior;cost;County;Data;data access;Data Science;Data Set;Dedications;density;Development;Development Plans;Dimensions;Disadvantaged;Economics;Education;Educational workshop;Effectiveness;Environment;Epidemiology;Ethnic Origin;Ethnic Population;Exposure to;Family;Feeling suicidal;Gender;Geography;Goals;Grant;group intervention;Health;health care availability;Health Promotion;Health Services Accessibility;Heterogeneity;Home;Housing;Hypertension;ideation;Immigrant;Immigration;improved;indexing;Individual;Infant Mortality;International;Intervention;Interview;Life;Life Cycle Stages;life span;Link;Literature;low socioeconomic status;Machine Learning;Medical;Mental Health;Mentors;Mentorship;Methodology;Michigan;Minority;Minority Groups;minority health;Modeling;Morality;Motivation;Native-Born;Neighborhoods;Not Hispanic or Latino;Outcome;Ownership;parent grant;parent project;Parents;perceived discrimination;physical conditioning;Play;Policies;Population;Poverty;Prevalence;preventive intervention;programs;protective factors;Proxy;psychosocial;Public Health;Race;racial discrimination;racial health disparity;racial identity;racial minority;racial population;random forest;regression trees;Religion;Reporting;Research;Research Activity;Research Personnel;residential segregation;Resources;Risk;Risk Factors;Role;Sampling;segregation;sex;Shapes;skills;social;social capital;Social Conditions;social group;social implication;Social isolation;Social Processes;social space;Social support;Sociology;Source;Structure;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide mortality;Suicide prevention;suicide rate;Surveys;System;Testing;theories;Time;Training;Translating;Trauma;United States National Institutes of Health;Urbanicity;Variant;Violence;Work

PROJECT_TITLE: Diversity Supplement: Aging, Major Life Transitions, and Suicide Risk

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Brain Disorders;Chronic Obstructive Pulmonary Disease;Coronaviruses;Dementia;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention

PHR: PROJECT NARRATIVE This research project intends to develop novel and high-impact statistical methods for studying the onset of asymptomatic diseases that can only be detected through periodic clinical examinations. These powerful new tools will enable investigators to analyze this important type of epidemiological data in a statistically efficient and unbiased manner, thereby facilitating the discovery of effective intervention and prevention strategies for many diseases of major public health significance, including diabetes, hypertension, HIV/AIDS, Covid-19, chronic obstructive pulmonary disease, cancer, and dementia.

PI_NAMEs: ZENG, DONGLIN  (contact)

PROGRAM_OFFICER_NAME: WOLZ, MICHAEL

PROJECT_TERMS: absorption;Acceleration;Address;Algorithms;Atherosclerosis Risk in Communities;Cardiovascular Diseases;Cessation of life;Characteristics;Chronic Obstructive Pulmonary Disease;clinical examination;Cohort Studies;Communities;Computer software;COVID-19;Cox Models;Cox Proportional Hazards Models;Data;Data Set;Dementia;Diabetes Mellitus;Disease;Disease Progression;Documentation;effective intervention;epidemiologic data;Epidemiology;epidemiology study;Equation;Event;expectation;experience;follow-up;Future;Gills;Goals;hazard;Heart Diseases;high dimensionality;HIV Infections;HIV/AIDS;Human;Hypertension;Infection;innovation;interest;Intervention;Journals;Life;Likelihood Functions;Link;Lung Diseases;Malignant Neoplasms;Mathematics;Maximum Likelihood Estimate;Medical;Methodology;Methods;Methylation;Modeling;Modernization;Monte Carlo Method;Myocardial Infarction;Normalcy;North Carolina;novel;Outcome;Outcome Measure;Participant;Periodicals;population health;prevent;Prevention strategy;primary outcome;Probability;Procedures;Process;Property;Proportional Hazards Models;Public Health;Publishing;Regression Analysis;Relaxation;Research;Research Personnel;Research Project Grants;Resort;Sampling;SARS-CoV-2 infection;semiparametric;simulation;sound;Statistical Methods;Stochastic Processes;Stroke;Survival Analysis;System;Techniques;theories;Time;time interval;tool;United States;Universities;user-friendly;Work

PROJECT_TITLE: Semiparametric Regression Analysis of Interval-Censored Data in Current Cohort Studies

STUDY_SECTION: ASPB

STUDY_SECTION_NAME: Analytics and Statistics for Population Research Panel B Study Section[ASPB]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: SAN FRANCISCO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: This is a Shared Instrumentation Grant proposal requesting funds to purchase a state-of-the-art Opera Phenix Plus High Content Screening System. The requested instrument would act as a single replacement for three IN Cell high content laser confocal systems serving three Cores that have been discontinued by their company with no parts or service available at the end of 2024. The new instrument will allow multidisciplinary teams of investigators at the Mission Bay Campus of the University of California to continue to conduct a wide range of cutting-edge experiments spanning developmental biology, cellular engineering, and neurophysiology, cancer biology and organoid development.

PI_NAMEs: FUNG, JENNIFER C (contact)

PROGRAM_OFFICER_NAME: AGGARWAL, MONIKA

PROJECT_TERMS: 3-Dimensional;Address;Air;Applications Grants;Area;Automation;Basic Science;Biological;Biomedical Research;California;Cells;Clinical Research;Computer software;Core Facility;developmental disease;environmental chemical;Grant;Health;high resolution imaging;Hour;Image;image processing;imaging system;Immersion;innovation;instrument;knockout gene;Lasers;lens;Malignant Neoplasms;Minor;Mission;Morphology;Nematoda;Nervous System Disorder;Neurons;Organoids;Pharmaceutical Preparations;Phase;programs;Refractive Indices;reproductive system disorder;Research;Research Personnel;Research Project Grants;Saccharomycetales;Sampling;San Francisco;screening;Services;small molecule;System;Time;Tissues;Translational Research;Translations;United States National Institutes of Health;Universities;Water;Zebrafish

PROJECT_TITLE: High content screening system - Perkin Elmer Opera Phenix Plus


ORG_CITY: BAR HARBOR

ORG_NAME: JACKSON LABORATORY

ORG_STATE: ME

PHR: PROJECT NARRATIVE Recent advances in biomedical research have demonstrated that analysis of single cells is essential for understanding the biological processes underlying development and disease. At The Jackson Laboratory (JAX), we have the capability to analyze diverse components in the pathways involved in protein production, including RNA and DNA molecules, and other molecules that modify levels of proteins generated from RNA or DNA, but currently we have no options for high-throughput identification of the “proteome,” i.e., the complete set of proteins, in a single cell. Access to the Bruker timsTOF SCP mass spectrometer and the accompanying cellenONE for sample processing requested in this application will provide investigators at both JAX and other Maine research institutions with access to a state-of-the-art single-cell proteomics system that will significantly advance research on a broad range of diseases.

PI_NAMEs: HOFFMANN, BRIAN ROBERT (contact)

PROGRAM_OFFICER_NAME: CHEN, YONG

PROJECT_TERMS: Address;Area;Basic Science;Biological;Biological Process;Biology;Biomedical Research;cancer cell;Cell Separation;Cell Surface Proteins;Cells;Chromatin;Clinical;Cognitive aging;Communities;Data;Development;Disease;Gene Expression;Genomics;Goals;Health;Human;Immune;improved;Individual;innovative technologies;insight;Institution;instrument;instrumentation;ion mobility;ion source;Label;Laboratories;Laboratory Research;Link;Maine;Malignant Neoplasms;mass analyzer;mass spectrometer;Mass Spectrum Analysis;metabolomics;Mission;Morphology;new therapeutic target;Organism;Phenotype;Population;Post-Translational Protein Processing;Protein Chemistry;Proteins;Proteome;Proteomics;Reproducibility;Research;Research Personnel;Resolution;Sampling;Services;single cell analysis;stem cell differentiation;System;Technology;The Jackson Laboratory;transcriptome;Translating

PROJECT_TITLE: Bruker Single Cell Proteomics Mass Spectrometer System


NIH_SPENDING_CATS: Cancer;Clinical Research;Dissemination and Implementation Research

PHR: Project Narrative  For most patients with cancer, high-quality surgery represents their best chance for cure. This proposal aims to evaluate the impact of six technical quality measures (“operative standards”) on cancer outcomes across 1400 hospitals accredited by the Commission on Cancer. Understanding whether these standards improve patient outcomes is critical in informing ongoing and future quality improvement programs.

PI_NAMEs: BOFFA, DANIEL J;DOSSETT, LESLY A (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Accreditation;Address;Adherence;Adjuvant Therapy;American College of Surgeons;Attention;Behavioral Mechanisms;Breast;Cancer Hospital;Cancer Patient;cancer recurrence;cancer site;cancer surgery;cancer type;Colon;cost;Data;Data Collection;Databases;design;Diagnostic;Diagnostic Neoplasm Staging;Education;Effectiveness;effectiveness evaluation;Elements;Evaluation;Event;evidence base;Excision;Expert Opinion;Feedback;Future;Guidelines;Hawthorne Effect;Heterogeneity;Hospitals;implementation evaluation;implementation facilitators;implementation outcomes;improved;improved outcome;Interruption;Interview;Investments;Lead;Link;Lung;lymph nodes;Malignant Neoplasms;Measures;Methods;multilevel analysis;Natural experiment;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Performance;Physicians;Process;programs;Publishing;quality assurance;Quality of Care;Rectum;Recurrence;Reporting;Residual state;Resources;Sampling;Schedule;screening;Self Assessment;Signal Transduction;Site;Site Visit;Solid Neoplasm;Staging;Surgeon;Surveys;Time Series Analysis;timeline;tool;Variant

PROJECT_TITLE: Evaluation of the Implementation and Effectiveness of the American College of Surgeons Operative Standards Program

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Eye Disease and Disorders of Vision

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE Mass spectrometry is a powerful analytical tool for separating and quantifying small molecule signaling agents in human physiology and disease. The SCIEX 7500 MS system can be used for measuring levels of compounds in biological samples while at the same time obtaining information about their chemical structure. There is a critical and substantial need for such an instrument to support the ongoing work of numerous NIH-funded investigators at Vanderbilt University Medical Center who are studying oxidized lipids (or fats) and their metabolites in human conditions associated with inflammation, including cancer, cardiology, and diabetes.

PI_NAMEs: MILNE, GINGER LOHR (contact)

PROJECT_TERMS: Academic Medical Centers;Area;Biological;Carboxylic Acids;Cardiovascular Diseases;Charge;Data;design;Detection;Diabetes Mellitus;Diabetic Retinopathy;Disease;Eicosanoids;experience;Funding;Gases;Generations;Human;Human Resources;Hypertension;Institution;instrument;ionization;Ions;Japan;Laboratories;lipid mediator;liquid chromatography mass spectrometry;Location;Maintenance;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measures;Medicine;Minor;operation;Ophthalmology;oxidized lipid;Pharmacology;Physiology;Power Sources;Request for Proposals;Research Personnel;response;Role;Sampling;Scanning;Sensitivity and Specificity;Signaling Molecule;Source;Specificity;Structure;System;Testing;Training;Universities;vision science

PROJECT_TITLE: Triple Quadrupole Mass Spectrometer System with QTRAP Functionality


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  DNA methylation is one of the oldest known epigenetic modifications to the genome, playing an important role in the gene regulatory landscape by typically acting in a repressive context, with aberrant DNA methylation observed in various diseases and developmental disorders. Despite its importance, this property has not been assessed during the dynamics of mammalian development at high-resolution. We have developed new tools that will enable us to address key hypotheses regarding the mechanistic role of DNA methylation in conjunction with other epigenetic properties that will we apply to the developing mouse embryo with a further focus on intestinal epithelial cell lineages.

PI_NAMEs: ADEY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Aberrant DNA Methylation;Address;Atlases;Biological Assay;Cell Lineage;cell type;Cells;Chromatin;Chromosome Mapping;Communities;cost;Coupled;Data;data portal;Data Set;demethylation;Deposition;Development;Developmental Biology;developmental disease;Disease;DNA mapping;DNA Methylation;Embryo;Embryonic Development;Epigenetic Process;epigenome;epigenomics;Epithelial Cells;Excision;experimental study;Gatekeeping;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Genome;genome-wide;Genomics;high throughput technology;Hour;insight;intestinal epithelium;Link;Mammalian Cell;Maps;Methylation;methylome;Modality;Modification;Molecular;Molecular Conformation;mouse model;Multiomic Data;multiple omics;Mus;Nature;novel;Nucleosomes;Pattern;permissiveness;Play;pluripotency;Population;Process;Production;Property;Regulation;Reporter;Research;Resolution;Resources;RNA;Role;single cell genomics;Specific qualifier value;stem;Tamoxifen;Techniques;Technology;Testing;Time;tool;transcriptomics

PROJECT_TITLE: DNA Methylation Dynamics of Mammalian Development

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Health Services;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Telehealth

ORG_CITY: BEVERLY

ORG_NAME: SEE YOURSELF HEALTH, LLC

PHR: Diabetes self-management education and support (DSME/S) helps people with T2DM learn and sustain healthy lifestyle behaviors and master complex disease management skills. Yet, only 7% of all adults with T2DM receive the DSME/S needed to effectively manage their diabetes care plan. New technologies supporting DSME/S programs are emerging, but most fail to meet the unique needs of older adults at high risk for unhealthy aging and cognitive decline related to poorly-controlled diabetes - creating a new digital divide. The See Yourself Health (SYH) team aims to bridge this digital health gap for older adults with the HOPE App, a new cloud-based immersive learning and telehealth program uniquely tailored for older adults with diabetes and clinically proven to maintain and improve cognitive and physical health.

PI_NAMEs: MITCHELL, SUZANNE  (contact)

PROGRAM_OFFICER_NAME: SAZONOVA, IRINA Y

PROJECT_TERMS: Active Learning;Adherence;Adult;Aging;Behavior;Businesses;Caring;Chronic Disease;Clinical;Clinical Trials;cloud based;Cognitive;Communication;Complex;Computer software;design;diabetes distress;diabetes management;Diabetes Mellitus;diabetes self-management;digital divide;digital health;Disease Management;Education;educational atmosphere;Epidemic;experience;feasibility testing;Health;health application;Health Care Costs;health management;Healthcare;healthy lifestyle;high risk;Impaired cognition;improved;Intervention;Learning;Life Style;new technology;Non-Insulin-Dependent Diabetes Mellitus;older adult;Outcome;Participant;patient engagement;Patient Outcomes Assessments;patient population;patient retention;Patients;peer support;Persons;Phase;physical conditioning;population health;Prediabetes syndrome;Predictive Analytics;programs;prototype;Reporting;Self Management;skills;Small Business Innovation Research Grant;social;Social Network;Technology;Telecommunications;telehealth;Testing;Time;tool;usability;Validation;virtual reality;Visit

PROJECT_TITLE: TABA for The HOPE App: An Immersive Telehealth Solution for Older Adults with Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(10)-B]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: Minimally invasive surgery affords the advantage of faster recovery, reduced hospital stays, improved functional outcomes and a quicker return to normal activities, as compared to open operations. The proposed hyperspectral laparoscopic stereo imaging system, which is enhanced by our advanced deep learning AI algorithms, can detect malignant and vital tissues during robot‐assisted laparoscopic radical prostatectomy and therefore potentially improve the oncologic outcome (undetectable prostate‐specific antigen with no evidence of cancer recurrence) and functional outcome (recovery of continence and erectile function). The real‐time hyperspectral laparoscopic stereo imaging system will be integrated with the commercial da Vinci robot and will provide new capabilities of detecting cancerous tissue and mapping physiological parameters during surgery, in turn helping reduce cancer recurrence and improve survivals and surgical outcomes.

PI_NAMEs: FEI, BAOWEI  (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: 3-Dimensional;Abdomen;Agreement;Angiography;Animals;artificial intelligence algorithm;Benign;Blood Circulation;Cancer Detection;Cancer Patient;cancer recurrence;Cancerous;Classification;Clinical;Clinical Trials;contrast imaging;Contrast Media;Data;Databases;deep learning;deep learning algorithm;deep neural network;Electronics;Endoscopes;Ensure;Environment;experience;fluorescence imaging;Freedom;functional improvement;functional outcomes;Funding;graph neural network;Half-Life;Hemoglobin;Hemorrhage;Histologic;Human;human data;human tissue;Image;image guided;imaging system;Imaging Techniques;Imaging technology;improved;In Situ;in vivo;indexing;Indocyanine Green;Industrialization;industry partner;Injections;innovation;insight;Intuition;Investigation;Label;Laparoscopes;Laparoscopic Surgical Procedures;learning network;Length of Stay;Light;machine learning method;Malignant - descriptor;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measurement;Medical;Methods;minimally invasive;neural network algorithm;Oncology;operation;Operative Surgical Procedures;optical imaging;Organ;Outcome;Pathologist;Pathology;Patients;Performance;Perfusion;Physiologic Monitoring;Physiological;Postoperative Period;preclinical study;preservation;Procedures;Prostate;Prostate-Specific Antigen;Prostatectomy;Quality of life;Radical Prostatectomy;Recovery;Research;Residual Neoplasm;Resolution;Resources;Robot;robot assistance;robotic system;Robotics;safety and feasibility;Screening for Prostate Cancer;Sensitivity and Specificity;Site;Specificity;Specimen;Speed;success;surgery outcome;survival outcome;System;Techniques;Testing;Time;tissue mapping;tissue oxygenation;Tissues;tool;Training;Translating;translational study;Translations;tumor;United States National Institutes of Health;Urologist;virtual;Water;Work

PROJECT_TITLE: A Real-Time Hyperspectral Laparoscopic Stereo Imaging System for Robot-Assisted Surgery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CTH-E (57)]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: BIRMINGHAM

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Assessment of metabolism, consisting of energy expenditure (the number of calories burned) and substrate oxidation (whether carbohydrate, fat, or protein is burned as fuel), is critical to the study of human health and disease. A whole-room indirect calorimeter provides the optimal means to measure multiple components of metabolism in studies related to obesity and other chronic metabolic diseases. The proposed room calorimeter system will provide UAB with a state-of-the-art tool for assessing human metabolism in pediatric and adult populations, leading to advances in knowledge related to both the development and treatment of obesity and related metabolic diseases.

PI_NAMEs: GOWER, BARBARA A (contact)

PROJECT_TERMS: Alabama;base;Carbon Dioxide;Chronic;Comprehensive Cancer Center;Diabetes Mellitus;Disease;doubly-labeled water;energy balance;Energy Metabolism;Exercise;Expenditure;feeding;Funding;Gases;Health;Hour;Human;Indirect Calorimetry;innovation;Intervention;Laboratories;Measurement;Measures;Metabolic;metabolic abnormality assessment;Metabolic Diseases;metabolic rate;Metabolism;Modality;Monitor;Nutrient;nutrition;Obesity;Oxygen Consumption;Pharmacologic Substance;Physical activity;portability;Production;programs;Publications;Recording of previous events;Research;Research Design;research facility;Research Personnel;respiratory;Rest;Services;Sleep;standard measure;System;systems research;Techniques;United States National Institutes of Health;Universities

PROJECT_TITLE: Indirect calorimetry system for research in human metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 ISB-M (30)]


NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Rare Diseases;Vaccine Related

ORG_CITY: LITTLE ROCK

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: PROJECT NARRATIVE Kaposi sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus that establishes lifelong chronic infections in lymphocytes and other cells, placing the host at risk for several cancers, especially persons who are immune suppressed or infected with HIV. Defining interactions between KSHV and the host, especially how viral proteins inhibit immunity, is important for identifying new methods of treating and preventing KSHV-related cancers. The work of this proposal will employ model systems to establish functions for determinants of KSHV pathogenesis and test roles for specific immune functions in viral control.

PI_NAMEs: FORREST, JAMES CRAIG (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immunity;Animal Model;Animals;antiretroviral therapy;Biological Models;cancer risk;CD4 Positive T Lymphocytes;Cell Physiology;cell type;Cells;Chronic;chronic infection;combinatorial;Data;Detection;Development;Disease;DNA Tumor Viruses;Episome;experimental study;Fostering;Future;gammaherpesvirus;Gene Transfer;Genes;Genetic Transcription;Genome;Goals;Herpesviridae Infections;HIV;HIV Infections;Homologous Gene;Human;Human Herpesvirus 8;Immune;Immune Evasion;immune function;Immune response;Immune System Diseases;Immunity;immunodeficiency;Immunology;Impairment;in vivo;Individual;infected B cell;Infection;Inflammatory;innovation;Kaposi Sarcoma;Knock-in;Laboratory mice;latency-associated nuclear antigen;latent infection;Lymphocyte;Lytic;lytic replication;Maintenance;Malignant Neoplasms;Mediating;member;Methods;Modeling;Morbidity - disease rate;mortality;Multicentric Angiofollicular Lymphoid Hyperplasia;Mus;Nature;next generation;next generation sequencing;non-drug;novel strategies;Oncogenes;Oncogenic;opportunistic pathogen;Outcome;pathogen;Pathogenesis;Persons;Pre-Clinical Model;Preclinical Testing;prevent;primary effusion lymphoma;Process;Productivity;promoter;protein function;Proteins;Publishing;recombinant virus;Repression;Rhadinovirus;Risk;Rodent;Role;Signal Pathway;T-Cell Depletion;targeted treatment;Testing;Therapeutic;therapy development;tool;Trans-Activators;transcriptome;vaccine evaluation;Viral;Viral Load result;Viral Pathogenesis;Viral Proteins;Virus;Virus Diseases;Virus Latency;Virus Replication;Work

PROJECT_TITLE: Defining KSHV LANA functions in viral pathogenesis and immune evasion

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: COLUMBIA

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

PHR: Project Narrative The uterus contains glands that are essential for pregnancy and contribute to uterine-based endometrial disorders and disease, yet the developmental biology of epithelium and gland differentiation remains poorly understood. This gap in our knowledge will be addressed through an integrative systems biology approach that will define critical cellular and molecular pathways governing epithelial differentiation and gland development in the newborn uterus. This research is expected to significantly advance our understanding of the developmental aspects of uterine biology, determinants of adult uterine function, and provide a foundation for the design of clinical therapies to prevent, identify and treat human reproductive problems involving uterine dysgenesis, dysplasia, or dysfunction.

PI_NAMEs: SPENCER, THOMAS E (contact)

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Address;Adenocarcinoma;Adenomyosis;Adult;Affect;Animal Model;Binding;Bioinformatics;Biological;Biological Process;Biology;blastocyst;Cell Differentiation process;Cell Lineage;cell type;Cells;Characteristics;Chromatin;Chromatin Modeling;chromatin remodeling;Clinical;Complication;Conceptus;Critical Pathways;Data;Decidual Cell Reactions;deep learning;design;Development;Developmental Biology;Diagnosis;Disease;Dysplasia;early pregnancy loss;Endometrial Disorder;endometrial organoid;endometriosis;Enhancers;Ensure;Environment;Epigenetic Process;Epithelial Cells;epithelial stem cell;Epithelium;Ethical Issues;Female infertility;Fertility;forkhead protein;Foundations;Functional disorder;functional genomics;Gene Activation;Gene Expression;gene regulatory network;Genetic;Genetic Models;Gland;gland development;Goals;Growth;Health;Human;implantation;In Vitro;in vivo;Infertility;infertility treatment;innovation;knockout animal;Knowledge;Maintenance;Mission;Molecular;Morphogenesis;mouse genetics;multiple omics;Multipotent Stem Cells;Mus;National Institute of Child Health and Human Development;Natural regeneration;Neonatal;neonatal mice;Newborn Infant;Organ;Organoids;Pathogenesis;Pathology;Pathway interactions;Physiological;Play;Pregnancy;Pregnancy loss;prevent;Prevention;Process;Publications;Publishing;Qualifying;recruit;Recurrence;Regenerative Medicine;Regulation;reproductive;Reproductive Biology;Research;Research Personnel;Research Priority;Research Project Grants;Role;Signal Transduction;Specific qualifier value;Stromal Cells;System;Systems Biology;Techniques;transcription factor;Transcriptional Activation;Uterine Diseases;Uterine Gland;uterine receptivity;Uterus;Woman

PROJECT_TITLE: Molecular Mechanisms Regulating Uterus Development

STUDY_SECTION: CMIR

STUDY_SECTION_NAME: Cellular, Molecular and Integrative Reproduction Study Section[CMIR]


ORG_CITY: PHILADELPHIA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative Changes in cell state and function are often observed in response to disease and understanding these changes are critical components in diagnosis and assessment of novel treatments for infection, cancer, autoimmunity, and many other diseases. Flow cytometry is a powerful technique that allows for the simultaneous classification, numeration, and functional analysis of cells in a high-throughput manner from patient samples and model systems. Drexel University is requesting funds to purchase a spectrally enabled BD High Throughput Sampler, Symphony A5 SE high parameter cell analyzer to support cellular analysis at an unprecedented level by NIH-funded researchers at Drexel and surrounding institutions.

PI_NAMEs: HADDAD, ELIAS K (contact)

PROJECT_TERMS: Biological Sciences;Biomedical Engineering;Cells;college;Core Facility;Flow Cytometry;Fluorescence;Funding;Heterogeneity;high throughput analysis;Human;Immunology;Individual;Institution;interdisciplinary collaboration;Lasers;Medicine;Microbiology;Minor;Mission;Mus;Operations Research;Pharmacology;Physiology;Proteins;Recording of previous events;Research;Sampling;success;System;Universities

PROJECT_TITLE: Acquisition of a BD High Throughput Sampler, Symphony A5 SE, to Promote Translational Discovery through Spectral Flow Cytometry

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-D (30)]


NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Genetics;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Pulmonary Fibrosis

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Severe viral pneumonia, such as SARS-CoV-2 pneumonia, can cause life-threatening damage in the gas exchange region of the lungs. Our goal is to understand how mitochondria affect lung healing and to develop new treatments that enhance lung repair in these patients.

PI_NAMEs: HAN, SEUNGHYE  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Adult;Affect;Alveolar;alveolar epithelium;Animals;ATP Synthesis Pathway;Attenuated;Automobile Driving;Bacterial Pneumonia;biological adaptation to stress;Cell Cycle Arrest;Cell Death;cell injury;Cells;Cessation of life;Characteristics;Clinical;Complex;COVID-19 pandemic;COVID-19 pneumonia;Credentialing;Cytokeratin;Data;Development;Epithelial Cells;epithelial repair;Epithelium;experimental study;Fibrosis;fibrotic lung;Functional disorder;Gases;Genes;Genetic;Genetic Markers;Genetic Transcription;Goals;healing;Human;Immune response;Impairment;Injury;Knockout Mice;Life;Link;Lung;lung development;lung injury;lung repair;Lung Transplantation;Mediating;Metabolic;Mitochondria;mitochondrial dysfunction;mitochondrial metabolism;Modeling;mouse model;Mus;NADH;NADH oxidase;Natural regeneration;Nature;Outcome;overexpression;Paper;Pathologic;Pathway interactions;Patients;pharmacologic;Pneumonia;Population;postnatal;postnatal development;prevent;programs;Protein Biosynthesis;Protein Subunits;Publishing;Pulmonary Fibrosis;pulmonary function;radiological imaging;repaired;Reporting;Research Personnel;Respiratory Failure;Respiratory Signs and Symptoms;Role;Sampling;Severities;single-cell RNA sequencing;Slice;small molecule inhibitor;stem cells;targeted treatment;Testing;Time;tool;Transitional Cell;Translations;Viral;Viral Pneumonia;Water

PROJECT_TITLE: Mitochondrial metabolism controls alveolar epithelial cell fate

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Project Narrative The Human Immune Monitoring Shared Resource (HIMSR) serves faculty and trainees at the University of Colorado Anschutz Medical Campus (CUAMC) and CU Cancer Center members across the front range campuses (National Jewish Health, CU Boulder, CSU, VA, Children's Hospital, etc), has strong institutional support, and a stable financial infrastructure. This proposal seeks funds for the acquisition of a new state-of- the-art hyperplex fluorescence imaging platform, the Lunaphore COMET, to transform the research capabilities at CUAMC and expand current multiplex immunohistochemistry (mIHC) tissue imaging capabilities of the HIMSR. The Lunaphore COMET offers high multiplexing capability, compatibility with multiple sample types, customizable panel design, and produces open-source quantitative images of whole tissues, making it a valuable tool for studies of complex tissue microenvironments and advancing disease diagnosis, treatment, and drug development.

PI_NAMEs: JORDAN, KIMBERLY R (contact)

PROJECT_TERMS: Antibodies;Area;assay development;Automation;Biological Assay;Certification;Collaborations;Colorado;Core Facility;Custom;Data;Dermatology;Development;Doctor of Philosophy;Epitopes;experience;flexibility;fluorescence imaging;Funding;Grant;Head and Neck Cancer;Hematology;Hepatology;Human;Image;Image Analysis;imaging capabilities;Imaging Device;imaging platform;imaging system;Immunohistochemistry;Immunologic Monitoring;Immunology;Infrastructure;innovation;Institution;instrument;instrumentation;interest;Jordan;Label;Leadership;liquid crystal polymer;mass spectrometric imaging;Medical;Microfluidics;Multiplexed Ion Beam Imaging;Nephrology;Oncology;open source;Peer Review;Principal Investigator;Publications;Qualifying;Research Assistant;Research Personnel;Resource Sharing;RNA;Stains;Technology;The University of Colorado Cancer Center;Time;Tissue imaging;Tissue Preservation;Tissues;transcriptomics;United States National Institutes of Health;Universities;virtual;Walking;whole genome

PROJECT_TITLE: High Parameter Fluorescence Imaging for Analysis of Tissue Microenvironments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CDB-J (30)]


ORG_CITY: NEW HAVEN

ORG_DEPT: PATHOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Obesity alcoholic miR-130b/301b concerning for i s a serious global health problem that i ncreases the risk of diabetes, cardiovascular diseases, non- fatty liver diseases, and certain cancers. This project will define mechanisms by which myeloid-derived  regulates beige adipogenesis and macrophage activation, thereby providing new insights the crosstalk between macrophages and beige adipocyte development in obesity and pave the way using miR-130b/301b and their gene networks as novel therapeutic targets and biomarkers.

PI_NAMEs: JIANG, SHAONING  (contact)

PROGRAM_OFFICER_NAME: BLONDEL, OLIVIER

PROJECT_TERMS: 5'-AMP-activated protein kinase;adipocyte differentiation;Adipocytes;adipose derived stem cell;Adipose tissue;Back;Cardiovascular Diseases;Cell Differentiation process;cell type;Cells;Circulation;Coculture Techniques;combat;comorbidity;Data;Data Analyses;diabetes risk;diet-induced obesity;Disease;Energy Metabolism;extracellular vesicles;Fatty acid glycerol esters;Flow Cytometry;Gene Expression;gene network;Gene Targeting;Genes;global health;Glucose Intolerance;Goals;High Fat Diet;Homeostasis;Human;human model;Impairment;improved;In Vitro;in vivo;Inflammation;inhibitor;insight;Insulin Resistance;Knockout Mice;Knowledge;lipid biosynthesis;Liver diseases;Macrophage;Macrophage Activation;Malignant Neoplasms;Mediating;Metabolic dysfunction;Metabolic stress;MicroRNAs;Mitochondria;mitochondrial metabolism;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;Obesity;overexpression;Oxidative Phosphorylation;Pathway interactions;posttranscriptional;problem drinker;Production;protective effect;Publishing;Regulation;response;Risk;Role;Signal Pathway;single-cell RNA sequencing;Source;stem;stem cells;Stimulus;Stromal Cells;subcutaneous;Testing;Therapeutic;therapeutic biomarker;therapeutic target;transcriptome sequencing;transcriptomics;Untranslated RNA;uptake

PROJECT_TITLE: Macrophage miR-130b/301b and beige adipogenesis

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: Decatur

ORG_NAME: VETERANS HEALTH ADMINISTRATION

ORG_STATE: GA

PHR: Stroke survivors with lower limb disability can improve their walking speed with high-intensity interval training (HIIT) rehabilitation therapy. However, some individuals may not respond to HIIT even when fully adherent to the program. To address this, we propose to build a predictive model that identifies if a Veteran with chronic subcortical stroke will improve their walking speed with HIIT by incorporating blood lactate as an early predictor of exercise response, and inhibitory neurotransmitter gamma-aminobutyric acid (GABA) and regional cerebral blood flow (CBF) as predictors of the brain’s potential to respond, while also taking into consideration other factors such as comorbidities, demographics, and fitness levels.

PI_NAMEs: KRISHNAMURTHY, LISA C. (contact)

PROJECT_TERMS: Address;Adherence;Adult;Aerobic;Aerobic Exercise;Age;Area;arterial spin labeling;Biological Markers;Blood;Blood Circulation;Brain;cardiorespiratory fitness;Cardiovascular system;Categories;Cerebrovascular Circulation;Chronic;chronic stroke;Citric Acid Cycle;Clinical;clinical biomarkers;Communities;comorbidity;Data;demographics;design;Development;disability;Educational Intervention;Equilibrium;Exercise;exercise intensity;exercise intervention;exercise program;exercise regimen;exercise rehabilitation;exercise training;experience;Fingers;fitness;functional gain;functional improvement;functional outcomes;gamma-Aminobutyric Acid;Glutamates;improved;Independent Living;Individual;innovative technologies;Intake;Interval training;Intervention;Lead;Leg;Link;Literature;Lower Extremity;machine learning prediction algorithm;Magnetic Resonance Imaging;Magnetic Resonance Spectroscopy;Measures;Metabolic;Modeling;Molecular;mortality;Motor;Muscle;Neurobiology;Neuronal Plasticity;neurophysiology;Neurotransmitters;older adult;Organ;Oxygen;Participant;Patients;Persons;Physical activity;Physical Fitness;predicting response;predictive marker;predictive modeling;programs;Quality of life;Recovery;rehabilitation science;Rehabilitation therapy;Reporting;Research;response;Rest;sedentary;Sensory;sex;Stroke;stroke patient;stroke rehabilitation;stroke survivor;Testing;Time;Training Programs;Vasodilation;Veterans;VO2max;Walking;walking speed

PROJECT_TITLE: What makes a responder, a responder? Biomarkers to help identify responders and resistors to high-intensity interval training for lower extremity chronic stroke

STUDY_SECTION_NAME: Brain Health and Injury[RRD1]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative;Neurosciences;Nutrition;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative – Funded/Parent Project Despite the recognized increased risks and consequences of mealtime difficulties and insufficient intake, people with ADRD are not provided with optimal person-centered mealtime care to manage the two interrelated and important health care problems (i.e., mealtime difficulties, insufficient intake). Developing an effective behavioral intervention that integrates person-centered mealtime care and management of risks of inadequate intake and malnutrition will address a significant long-term care need in adults with ADRD in diverse care settings, because such an intervention may have great potential to decrease mealtime difficulties, optimize intake, and improve nutrition and quality of life which are fundamental health needs as cognition declines. As a logical first step in intervention development and testing, data obtained from the proposed study will provide critical information to guide the refinement of the intervention protocol and clinical trial procedures and to estimate effect sizes for sample size calculation, which will be used in a future large-scale clinical trial that aims to evaluate the efficacy of OPTIMAL on resident outcomes (e.g., mealtime difficulties, intake). Project Narrative – Administrative Supplement The PI has experienced a critical life event during the award period, which along with pandemic-related delays has impacted the progress of the funded project and increased the needs for more time and personnel support for the completion of the remaining study activities of the funded project. The administrative supplement support is critically needed to provide 1-year personnel support for a full-time research support coordinator and research assistants who have been working collaboratively with the PI and well trained to complete the remaining activities of the funded project. The administrative supplement support will ensure the continuity of the PI (Dr. Wen Liu)’s program of research in dementia mealtime care, support the PI to return to full productivity at the end of the supplement period, and facilitate PI’s transition from mentored career development award to research independence.

PI_NAMEs: LIU, WEN  (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Address;Adherence;Administrative Supplement;Adult;Aging;aging population;Alzheimer's disease related dementia;Applications Grants;Area;Award;Behavior;Behavior Therapy;Behavioral;behavioral clinical trial;Behavioral Research;Behavioral Symptoms;Body Weight decreased;care outcomes;care providers;career;Caring;Clinical;clinical care;Clinical Research;Clinical Trials;Code;Cognition;Collaborations;community engagement;Conduct Clinical Trials;Consent;Cues;Data;Data Analyses;Data Set;data structure;Dehydration;Dementia;design;Development;Eating;efficacy evaluation;Ensure;Evaluation;Event;evidence base;Exhibits;experience;Experimental Designs;Focus Groups;Funding;Future;Goals;Group Interviews;Health;Healthcare;Home Nursing Care;Human Resources;Hydration status;improved;Individual;Infection;Information Dissemination;innovation;Intake;Intervention;intervention refinement;Interview;Iowa;Joints;K-Series Research Career Programs;Knowledge;Life;Literature;Long-Term Care;Malnutrition;Manuscripts;member;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;Morbidity - disease rate;mortality;Neurobehavioral Manifestations;Nursing Homes;nursing intervention;nutrition;Outcome;pandemic disease;parent project;patient oriented;Patient-Focused Outcomes;Perception;person centered;Personal Satisfaction;Persons;pilot test;Population;Positioning Attribute;Pre-Post Tests;preference;Preparation;Procedures;Productivity;programs;Protocols documentation;Quality of Care;Quality of life;Recommendation;recruit;Research;Research Activity;Research Assistant;Research Personnel;Research Project Grants;Research Support;Residential Treatment;Resolution;Resources;Risk;Risk Management;Sample Size;Scheme;Science;Series;skills;Social Interaction;Source;Statistical Methods;Structure;systematic review;Testing;theories;therapy development;Time;tool;Training;Training Activity;treatment as usual;Treatment Efficacy;United States National Institutes of Health;Universities;Videotape;Work

PROJECT_TITLE: Optimizing Mealtime Care (OPTIMAL): Development and Pilot Testing of a Person-Centered Mealtime Care Intervention for Nursing Home Residents with Alzheimer's Disease and Related Dementias (ADRD)

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Aging;Clinical Research;Clinical Trials and Supportive Activities;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

PHR: Narrative Older adults experience inadequate muscle recovery following a disuse period leading to reduced muscle function and increased risk of falls. We have proposed to conduct a randomized clinical trial to test if metformin can improve muscle recovery in older adults and that this would occur by reducing cellular senescence and muscle fibrosis. These findings will aid in the future use of metformin to reduce cellular senescence and promote muscle recovery in aged individuals.

PI_NAMEs: DRUMMOND, MICAH J (contact)

PROGRAM_OFFICER_NAME: BOYCE, AMANDA T

PROJECT_TERMS: Acceleration;Adopted;age related;age-related disease;Aging;aging population;Cell Aging;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cells;Clinical;Clinical Trials;Collagen;Controlled Clinical Trials;Coupled;Data;Deposition;disability;Disuse Atrophy;Dose;Double-Blind Method;Event;Excision;experience;experimental study;Extracellular Matrix;fall risk;falls;Fibrosis;Functional disorder;Future;Goals;Growth;hallmarks of aging;Harvest;Health;Human;Immobilization;Immune;Immune System Diseases;Immune Targeting;immunoregulation;Impairment;improved;In Vitro;in vivo;Inflammatory;inflammatory modulation;injured;injury recovery;intercellular communication;interest;interstitial;interstitial cell;Limb structure;Macrophage;Mediator;Metabolic Diseases;Metformin;Methodology;Microscopy;Mus;Muscle;muscle aging;Muscle Cells;Muscle function;muscle regeneration;Muscle satellite cell;Myoblasts;myogenesis;novel;older adult;older patient;Operative Surgical Procedures;Outcome;Participant;Phase;Phenotype;Placebo Control;placebo group;Placebos;Play;Population;Positioning Attribute;Predisposition;progenitor;Property;Randomized;randomized placebo-controlled clinical trial;randomized, clinical trials;Recovery;Regulation;Replacement Arthroplasty;Research;Research Personnel;resilience;response;Role;Sampling;senescence;senescence associated secretory phenotype;senescent cell;senomorphic;Senotherapeutic;single-cell RNA sequencing;Skeletal Muscle;Spiders;stem;stem cells;stressor;Techniques;Testing;Therapeutic;Time;Traction

PROJECT_TITLE: Leveraging senotherapeutic properties of metformin to improve collagen remodeling during muscle regrowth in older adults

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]