NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Lung;Neurosciences;Rare Diseases

PHR: Coxiella burnetii causes the debilitating disease Q fever, a flu-like respiratory disease that can progress to chronic endocarditis. Although endocarditis is the most severe form of this disease, we currently have no effective therapeutics to combat this potentially fatal disease. The overall goal of this proposal is to characterize the impact of new host-directed drugs on C. burnetii parasitism of primary human alveolar macrophages, which will suggest potential as novel anti-Q fever therapies.

PI_NAMEs: VOTH, DANIEL E (contact)

PROGRAM_OFFICER_NAME: PERDUE, SAMUEL S

PROJECT_TERMS: Acute;Adrenergic Agents;Alveolar Macrophages;Anti-Inflammatory Agents;Antibiotics;Autophagocytosis;Autophagosome;Bacterial Infections;Biochemical;Cell membrane;Cell model;Cells;Cellular biology;chemokine;Chronic;Clinical Trials;combat;Coxiella burnetii;Cyclic AMP-Dependent Protein Kinases;cytokine;Data;Disease;disease model;Dopamine;drug action;Drug Targeting;Endocarditis;Endosomes;Enzymes;Epinephrine;Event;experimental study;extracellular;FDA approved;flu;Future;Goals;Growth;Human;Immune response;Immune signaling;in vivo;Induced Hyperthermia;Infection;Inflammatory;Innate Immune Response;Legionella pneumophila;Light;Lung;Lung Diseases;Lysosomes;Macrophage;Membrane;Metabolic;Methods;Microscopy;Moods;neurotransmitter antagonist;Neurotransmitter Receptor;Neurotransmitters;Norepinephrine;novel;Nutrient;Parasites;parasitism;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Pharmaceutical Preparations;Phenotype;Physiology;prevent;Production;Psychoses;Q Fever;recruit;Regulation;Research;Respiratory Disease;respiratory pathogen;Respiratory Tract Infections;response;Role;Serotonin;Signal Pathway;Signal Transduction;Signaling Molecule;Slice;Structure of parenchyma of lung;System;Testing;Therapeutic;therapeutically effective;Vacuole;Work

PROJECT_TITLE: Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


ADMINISTERING_IC: AA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: BROOKLYN

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE NIH Public Health Relevance: Parents wield both genetic and social-environmental impact on children’s brain and behavior development and can contribute to both risk and resiliency to alcohol use disorder (AUD)[2] with ample evidence showing that children of alcoholics are four times more likely than other children to develop AUD, emphasizing intergenerational transmission of genetic risk[3]. Aspects of parenting are also critical to the effective development of children’s brain architecture, functions and capacity with neglected and maltreated children manifesting atypical brain development, increased rates of alcohol problems and other neuropsychiatric disorders,[11-19] but positive parenting (e.g., parent-child closeness) has been linked to lower levels of externalizing behaviors and higher effortful control in children, and has been posited as critical for normative development of self-regulatory capabilities, higher-level social, emotional, and cognitive development and the neurobiological systems that subserve them.[20-23] Unlike, extant research on AUD that focuses on studying risk factors, this K01 research proposal will focus on factors that promote resilience for AUD and given that parenting factors are among the most important variables in gene- environment interaction effects on resilience and risk for AUD, I will examine the role and interplay of parenting (e.g., parental bonding) and genetic (e.g., family history density, polygenic risk scores for AUD) factors on the development of neurocognitive function (e.g., response inhibition), and alcohol problems (e.g., alcohol problems) across adolescence and young adulthood, critical neurodevelopmental periods.

PI_NAMEs: PANDEY, GAYATHRI  (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: 15 year old;Address;Adolescence;Adolescent and Young Adult;Adult Children;Affect;Age;Alcohol abuse;alcohol behavior;alcohol misuse;alcohol risk;alcohol use disorder;alcohol use initiation;Architecture;Area;Behavior;Behavioral;binge drinking;Black Populations;Brain;Buffers;career;Characteristics;Child;Child Development;Child Rearing;children of alcoholics;Clinical Psychology;Cognition;cognitive development;cognitive task;Complex;Consultations;critical period;Data;Decision Making;density;Development;Disadvantaged;Disease;Early Intervention;Emotional;Emotions;Environmental Impact;Environmental Risk Factor;Epidemiology;ethnic difference;Ethnic Origin;Event-Related Potentials;experience;externalizing behavior;Family;Foundations;frontal lobe;Future;Gender;gender difference;gene environment interaction;Genetic;genetic epidemiology;Genetic Risk;genetic risk factor;Genomics;Goals;Health Disparities Research;health disparity;high risk;high-risk adolescents;Human;improved;Informal Social Control;intergenerational;Intervention;intervention program;intimate behavior;Knowledge;Link;maltreated children;Measures;Mediating;Mental Health;Mentorship;Motivation;neglect;neural;Neurobiology;Neurocognitive;neuropsychiatric disorder;Neurosciences;offspring;parental influence;parental monitoring;parental role;Parents;Pathway interactions;polygenic risk score;Population Heterogeneity;precision medicine;Prevention;Prevention program;Prevention strategy;problem drinker;programs;promote resilience;psychosocial;Psychosocial Factor;public health relevance;Race;racial difference;Recording of previous events;Reporting;Research;Research Personnel;Research Proposals;resilience;response;Risk;Risk Factors;Role;Sampling;scaffold;skills;social;social determinants;Social Psychology;Substance abuse problem;substance use;Symptoms;System;Time;Training;transmission process;United States National Institutes of Health;Variant;young adult

PROJECT_TITLE: Interplay of parenting, genetics, and brain function in trajectories of resilience and risk for AUD among high-risk adolescents and young adults.

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Alcohol and cannabis are often used together such that their effects overlap (known as `simultaneous use') but evidence is conflicting regarding whether simultaneous use promotes increased or decreased alcohol intake, and little is known about the neural mechanisms that underlie simultaneous use. Real-world doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, intravenous alcohol self-administration and naturalistic co-use patterns, and findings could impact public health and inform individual choices regarding co-use of cannabis and alcohol.

PI_NAMEs: GOWIN, JOSHUA LEIGH (contact);KAROLY, HOLLIS C

PROGRAM_OFFICER_NAME: GRAKALIC, IVANA

PROJECT_TERMS: Acute;Adult;Affect;Agonist;Alcohol consumption;alcohol cue;alcohol effect;alcohol misuse;alcohol response;alcohol reward;alcohol use disorder;Alcohols;Binding;Blood;Blood alcohol level measurement;Brain;Brain region;brain reward regions;Brain scan;cannabinoid receptor;Cannabis;cannabis administration;cannabis cue;Cannabis retail;capsule;Chemosensitization;CNR1 gene;Consumption;craving;Cross-Over Studies;Crossover Design;cue reactivity;Cues;Data Collection;diaries;disorder risk;Dopamine;Dose;Double-Blind Method;Dronabinol;Drug Kinetics;drug reward;endogenous cannabinoid system;Environment;Enzymes;experience;Functional Magnetic Resonance Imaging;Genetic Variation;Heavy Drinking;Human;imaging study;Individual;Individual Differences;Intoxication;Intravenous;Laboratories;laboratory experiment;Laboratory Research;Laboratory Study;Legal;Ligands;Link;marijuana use;Mediating;Motivation;MRI Scans;neural;neural circuit;neural correlate;neuromechanism;Oral;Outcome;Paper;Participant;Pattern;Placebo Control;Placebos;Procedures;Public Health;recruit;Reporting;Research;response;reward circuitry;reward processing;Rewards;Risk;Self Administration;Signal Transduction;Testing;Tetrahydrocannabinol;Time;Uncontrolled Study;Work

PROJECT_TITLE: Effects of THC on Alcohol Consumption and Neural Correlates of Reward

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Lung;Lung Cancer

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Non-small cell lung cancer (NSCLC) is a highly aggressive disease with dismal prognosis due to treatment resistance and disease recurrence. Immunotherapy targeting PD-1 immune checkpoint or its ligand PD-L1 (PD- 1/PD-L1) is an established first-line treatment for NSCLC, yet long-term disease control occurs in less than 25% of patients. Because evidence shows that the typically hypoxic nature of NSCLC tumors contributes to their treatment resistance, we propose to investigate the role of tumor hypoxia as a modulator of immune privilege in treatment-refractory NSCLC tumors.

PI_NAMEs: BENEJ, MARTIN  (contact)

PROGRAM_OFFICER_NAME: JAKOWLEW, SONIA B

PROJECT_TERMS: Address;anti-cancer treatment;Antigens;ATAC-seq;Cancer Model;Cancer Patient;cancer therapy;CD8-Positive T-Lymphocytes;Cessation of life;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinical;Clinical Management;clinical translation;clinically relevant;Data;Development;Disease;disorder control;effector T cell;Epigenetic Process;epigenome;exhaust;exhaustion;experience;Flow Cytometry;Foundations;Functional disorder;Future;Genes;Genetic;Goals;Hypoxia;Immune;immune cell infiltrate;immune checkpoint;immune checkpoint blockade;immune resistance;Immune Targeting;Immunomodulators;Immunotherapy;Impairment;improved;In Vitro;in vivo;in vivo monitoring;Infiltration;inhibitor;innovation;Interferon Type II;Knock-out;Knowledge;Lead;Ligands;Literature;Luciferases;Lysine;Malignant neoplasm of lung;Mediating;Methodology;Methods;Mitochondria;Modeling;Monitor;mouse model;Mus;nanoprobe;Nature;Neoadjuvant Therapy;Non-Small-Cell Lung Carcinoma;novel;Outcome;Oxygen;Papaverine;Patients;Pattern;Pharmaceutical Preparations;Population;pressure;progenitor;Prognosis;programmed cell death ligand 1;programmed cell death protein 1;programs;Recurrent disease;Refractory;Refractory Disease;Repression;Research;Research Personnel;response;Role;Safety;T cell infiltration;T-Lymphocyte;T-Lymphocyte Subsets;Therapeutic;therapy resistant;Transgenic Mice;Transition Career Development Award (K22);treatment response;tumor;tumor growth;tumor hypoxia;tumor microenvironment;United States

PROJECT_TITLE: Targeting mitochondrial oxygen demand to overcome hypoxic immune privilege of NSCLC tumors

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 RTRB-R (O1)]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Atherosclerosis;Cardiovascular;Childhood Obesity;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Human Genome;Liver Disease;Maternal Health;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: AMHERST

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: Maternal hypercholesterolemia programs enhanced susceptibility to nonalcoholic fatty liver disease in offspring. This proposal will explore hepatic epigenomic adaptations to excessive cholesterol exposure and examine maternal supplementation of phytosterols and phytostanols as a protective intervention.

PI_NAMEs: BUCK, MICHAEL JOSEPH;RIDEOUT, TODD  (contact)

PROGRAM_OFFICER_NAME: ROSS, SHARON A

PROJECT_TERMS: Address;Adolescence;Adult;adverse pregnancy outcome;Animals;Blood;Child;Childhood;Cholesterol;comparative efficacy;Conceptions;Data;Deposition;Development;Diet;differential expression;Disease Progression;disorder risk;DNA Methylation;DNA Modification Methylases;Dyslipidemias;effective intervention;Enzymes;Epigenetic Process;epigenome;epigenomics;experience;Exposure to;Fatty acid glycerol esters;Fatty Acids;fetal;Fetal Development;fetal programming;Fetus;Fright;Functional disorder;Gene Expression;Genes;Gestational Diabetes;Goals;Growth;Growth and Development function;Hepatic;histone modification;Human;hypercholesterolemia;Immunoprecipitation;improved;in utero;Infiltration;Inflammatory Response;Intervention;Intestinal Absorption;intrauterine environment;Knowledge;Life;Life Cycle Stages;Link;Lipids;Lipoproteins;Low Birth Weight Infant;maternal obesity;maternal serum;mature animal;Mediating;Memory;Metabolic;Metabolic dysfunction;methylation pattern;Modification;Molecular;mother nutrition;Mothers;mouse model;Mus;National Institute of Child Health and Human Development;non-alcoholic fatty liver disease;novel;nutrition;Obesity;offspring;organ growth;oxidized lipid;Pathologic;Pathology;Pattern;pediatric non-alcoholic fatty liver disease;Pharmaceutical Preparations;Phytosterols;Plants;Pre-Eclampsia;Predisposition;Pregnancy;Premature Birth;prenatal exposure;Prevalence;Production;programs;Regulator Genes;Research;Research Priority;response;Safety;Signal Transduction;Steatohepatitis;Supplementation;Toxic effect;transcriptome;transmission process;Triglyceride Metabolism;Triglycerides;Woman;Work

PROJECT_TITLE: Epigenetic Mechanisms in Developmental Programming of Hepatic Lipid Dysfunction by Maternal Hypercholesterolemia

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Obstetrics and Maternal-Fetal Biology Study Section[CHHD-B]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Patient Safety

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Clear, realistic goals for surgery are not routinely identified during surgical consultations for older adults, presenting a barrier to person-centered surgical treatment. This proposal uses the NIH Stage Model to refine, adapt, and pilot test an existing prototype intervention that supports communication about goals for surgery among older patients, families, and surgeons during surgical consultations. The resulting intervention will advance person-centered surgical care for the growing population of older adults facing major surgery.

PI_NAMEs: COHAN, JESSICA N (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;Address;Age;Aging;aging related;Ambulatory Surgical Procedures;Behavior Therapy;Biometry;Blood Vessels;Board Certification;career;career development;Caregiver research;Caring;Clinic;Clinical;Clinical Trials;Cognition;Cognitive;Colorectal;Communication;Communication Tools;Consultations;Data;Dedications;design;Development Plans;Diagnosis;Disability prevention;Discipline;Documentation;efficacy trial;Elderly;Emotions;Ensure;evaluation/testing;expectation;Face;Family;Feasibility Studies;field study;Focus Groups;Functional impairment;Future;Geriatrics;Goals;Health;Health Priorities;Impaired cognition;insight;Institution;Intervention;intervention refinement;K-Series Research Career Programs;Leadership;Life;Life Support Care;Measures;Mechanics;Medical Records;Mentors;Mentorship;Modeling;multi-site trial;Multicenter Trials;multidisciplinary;multiple chronic conditions;novel;older adult;older patient;Older Population;Operative Surgical Procedures;Outcome;Outpatients;overtreatment;Patient Outcomes Assessments;Patients;person centered;Personal Satisfaction;Pilot Projects;pilot test;Population;Positioning Attribute;Pragmatic clinical trial;primary outcome;Procedures;Process;Production;prototype;Provider;psychosocial;Quality of life;repaired;Research;Research Personnel;Risk;Scientist;secondary outcome;Site;skills;Surgeon;surgery outcome;symptom treatment;Testing;therapy design;therapy development;Training;Treatment Efficacy;Uncertainty;United States National Institutes of Health;University resources;Utah;Work

PROJECT_TITLE: Development of an intervention to ensure the goals of surgical treatment are valuable to older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

PHR: NARRATIVE  T cells responding to tumors or chronic infection tend to become hyporesponsive, yet T cells retain function despite persistent antigen during autoimmune disease. I propose several experiments to identify the molecular details of transcriptional programs that control the function of self-antigen specific T cells. These analyses will define transcriptional control of autoimmune responses and identify potential therapeutic targets to limit autoimmunity.

PI_NAMEs: SHAW, LAURA  (contact)

PROGRAM_OFFICER_NAME: SPAIN, LISA M

PROJECT_TERMS: Address;Affinity;antigen-specific T cells;Antigens;Autoantigens;Autoimmune Diseases;Autoimmune Responses;Autoimmunity;autoreactive T cell;autoreactivity;CD8-Positive T-Lymphocytes;Cell Physiology;Cells;Characteristics;Chronic;Chronic Disease;chronic infection;Clone Cells;cytokine;Data;Diabetes Mellitus;disorder control;Enabling Factors;Environment;exhaust;exhaustion;experimental study;Exposure to;Family;Gene Expression;Genes;Genetic Transcription;Human;Immune response;Inbred NOD Mice;Insulin;Insulin-Dependent Diabetes Mellitus;Link;Malignant Neoplasms;Mentors;MHC Interaction;Modeling;Molecular;mouse model;Mus;nuclear factors of activated T-cells;Nuclear Receptors;Pancreas;Pattern;Peptides;Phenotype;programs;Proteins;receptor;receptor expression;risk variant;self-renewal;single-cell RNA sequencing;Specificity;Structure of beta Cell of islet;T-Lymphocyte;T-Lymphocyte Subsets;Testing;therapeutic target;Thymocyte Selection;tool;Training;transcription factor;Transcriptional Regulation;tumor;Virus;Virus Diseases

PROJECT_TITLE: Transcriptional control of T cell function during type 1 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: JOHNSON CITY

ORG_NAME: EAST TENNESSEE STATE UNIVERSITY

ORG_STATE: TN

PHR: Narrative There is now compelling evidence that the innate immune system can be “trained” to respond more rapidly and effectively to pathogens. We have synthetized sugars which may stimulate the immune system to express the trained immune response. We expect to identify specific synthetic sugars which will be evaluated as new and novel immune stimulating drugs.

PI_NAMEs: WILLIAMS, DAVID L. (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Address;Animal Model;beta-Glucans;Biological Products;Candida albicans;Cell Wall;Characteristics;chemical synthesis;Child;Critical Illness;Data;Development;Disease;Dose;drug candidate;Elderly;FDA approved;Formulation;Frequencies;fungus;Glucans;glycomimetics;Goals;Gram-Positive Bacteria;Human;Immune;Immune response;Immune system;Immunity;Immunocompromised Host;Immunologic Memory;Immunologic Stimulation;In Vitro;in vivo;Infection;Innate Immune System;Laboratories;Length;Libraries;Ligands;Memory;Methods;mimic natural products;Molecular;Molecular Conformation;Molecular Weight;monocyte;nanoparticle;Natural Immunity;Natural Products;novel;novel strategies;Organism;particle;Particle Size;pathogen;pathogenic fungus;pathogenic virus;peripheral blood;Pharmaceutical Preparations;Phenotype;Polymers;prevent;Procedures;prophylactic;Reagent;Reproducibility;Research;Resistance;Resistance to infection;response;Side;Silicon Dioxide;Source;Structure;Structure-Activity Relationship;Study models;sugar;Testing;Therapeutic;Training;Vertebral column;Vulnerable Populations;Water

PROJECT_TITLE: Glucan glycomimetics: A new approach to stimulating innate immune training

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: NEW YORK

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE High blood pressure during pregnancy can lead to serious health complications during the birthing process, making the decision between attempting vaginal birth (through an induction of labor) or proceeding with cesarean delivery very critical. This study will identify the benefits and risks of each birthing option from multiple perspectives and create a framework that can help predict which approach is better for each patient. This will lead to patients receiving more personalized and safe medical care.

PI_NAMEs: PENFIELD, CHRISTINA  (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: Abdomen;Adhesions;Adverse event;Benefits and Risks;Birth;Blood coagulation;career;Caring;Cesarean section;Classification;Clinical;clinical decision-making;Code;Cognitive;Data;Data Set;Decision Making;Decision Modeling;design;Discipline of obstetrics;Disease;Event;evidence base;experience;Fetal Growth Retardation;Fetus;Focus Groups;Foundations;Functional disorder;Future;Gestational Age;Goals;Guidelines;Health;Hemorrhage;high risk;Hospitals;Hypertension;improved;improved outcome;Individual;individual patient;Induced Labor;Interview;Kidney Failure;Labor Complications;large datasets;Liver;Maternal Health;maternal morbidity;maternal outcome;maternal risk;Medical;Mentorship;Methods;Modeling;Morbidity - disease rate;neonatal health;Newly Diagnosed;Obesity;Operative Surgical Procedures;Organ;Outcome;Patient Preferences;Patients;Pelvis;Perinatal Epidemiology;Persons;Pharmaceutical Preparations;Physicians;Placenta Accreta;preference;Pregnancy;Pregnancy Complications;pregnancy disorder;pregnant;Probability;Process;programs;Pulmonary Edema;Qualitative Methods;Recovery;Reporting;Research;Research Personnel;Research Proposals;Review Literature;Risk;risk prediction;Route;Science;Scientist;Seizures;Severities;Site;skills;Specific qualifier value;Specificity;Stroke;Symptoms;Techniques;Time;Training;trend;Uterine Rupture;Vaginal delivery procedure;Variant;Work;Wound Infection

PROJECT_TITLE: Optimizing decision-making to improve maternal outcomes in high-risk pregnant patients with hypertensive disorders - Resubmission - 1


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE γ-Secretase is a key enzyme involved in Alzheimer’s disease (AD). To better understand the γ-secretase biology and assist AD drug discovery, tools to image the γ-secretase in AD human brains will be valuable. The aim of this research project is to develop a potent γ-secretase positron emission tomography (PET) probe with appropriate performance characteristics to support the clinical trial of γ-secretase modulators in AD intervention.

PI_NAMEs: XU, YULONG  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: abeta deposition;Affect;Affinity;alpha secretase;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Amyloid beta-42;Amyloid beta-Protein;Amyloid beta-Protein Precursor;analog;Animals;Attention;Autopsy;beta secretase;Biology;Brain;Cause of Death;Characteristics;clinical translation;Clinical Trials;Cognitive deficits;Data;density;design;Development;disease phenotype;drug discovery;Drug Kinetics;Enzymes;Event;Functional disorder;gamma secretase;Generations;Goals;Grant;High Pressure Liquid Chromatography;Human;human disease;Image;Image Analysis;Imaging Device;in vivo;inhibitor;insight;Intervention;Investigational Drugs;kinetic model;Kinetics;Lead;Macaca mulatta;Magnetic Resonance Imaging;Membrane;Memory Loss;microPET;Modeling;Modification;Molecular;molecular imaging;Nature;neurochemistry;Neurodegenerative Disorders;Neurofibrillary Tangles;neuropathology;neurotoxic;nonhuman primate;novel;Pathway interactions;Penetrance;Performance;Persons;Plasma;Positron-Emission Tomography;protein aggregation;Proteins;Publications;Pyridazines;quantitative imaging;Radioactive;Radioactivity;radiochemical;Radiolabeled;radiotracer;Reaction;Reaction Time;Reagent;Research Project Grants;Rodent;Sampling;Senile Plaques;Series;Solvents;tau Proteins;tau-1;Temperature;therapeutic target;tool;Transgenic Mice;Translating;United States;United States National Institutes of Health;uptake;Visualization;Wild Type Mouse;X-Ray Computed Tomography

PROJECT_TITLE: Development of Novel γ-Secretase PET Agents for the Exploration of AD Pathology

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Neurosciences;Pediatric

ORG_CITY: BALTIMORE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Altered experience or injury in development leads to deficits in speech and language perception that might originate in altered function of the primary auditory cortex. The proposed experiments elucidate how sounds engage these circuits and how subplate neurons shape the developing auditory cortex. These studies lay the groundwork for a better understanding of auditory cortical development, add to the knowledge of normal development in children, and add to the understanding of the effects of deafness and the causes of neurodevelopmental disorders. 1

PI_NAMEs: KANOLD, PATRICK O (contact)

PROGRAM_OFFICER_NAME: POREMBA, AMY

PROJECT_TERMS: Adult;Auditory;Auditory area;auditory stimulus;Auditory Threshold;autism spectrum disorder;Axon;Brain;brain abnormalities;Central Auditory Processing Disorder;Child;Cochlear Implants;Complex;critical period;deafness;Development;Disease;Drug Exposure;Early-life trauma;Excision;experience;experimental study;Fetus;Frequencies;Functional disorder;Funding;Human;Imaging Techniques;in utero;in vivo;in vivo imaging;Injury;Intervention;Knowledge;language impairment;language perception;Lesion;Maps;Monitor;Mus;Neonatal;neural circuit;neural correlate;Neurodevelopmental Disorder;neuronal circuit disruption;neuronal circuitry;Neuronal Plasticity;Neurons;Newborn Infant;noise exposure;opioid exposure;preference;Primates;Process;Recovery of Function;response;Role;Schizophrenia;Sensory;sensory cortex;Sensory impairment;sensory stimulus;Shapes;Somatosensory Cortex;sound;Speech Perception;Stimulus;teacher;Techniques;Testing;Thalamic structure;Tinnitus;Transgenic Mice;trauma exposure;Visual Cortex;vocalization;Voice;Work

PROJECT_TITLE: NEURONAL CIRCUITS AND PLASTICITY OF NEONATAL AUDITORY CORTEX

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Infectious Diseases;Machine Learning and Artificial Intelligence;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention;Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: INSTITUTE FOR SYSTEMS BIOLOGY

ORG_STATE: WA

PHR: Narrative Using secondary data from previous studies, we will conduct a detailed analysis of immune repertoire dynamics in patients with post-acute sequelae of COVID-19 (PASC), as compared with patients with a history of COVID-19 without PASC, and with healthy individuals. We will build cohort-specific models of thymic selection, examining how these models differ between cohorts and over time, inferring the dynamics of repertoire size, sharing and diversity, and uncovering the receptor features which drive these differences. In addition, we will develop new methods for the integration of T-cell repertoire and single cell dynamics, which will be of benefit for future research across a wide range of infectious diseases and immune-mediated medical conditions.

PI_NAMEs: HADLOCK, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: 2019-nCoV;Acceleration;acute infection;adaptive immunity;Address;Affect;Antibody titer measurement;Benchmarking;Biological Models;Biophysics;Cells;cohort;Communicable Diseases;comorbidity;COVID-19;COVID-19 pandemic;COVID-19 patient;Data;Dedications;Electronic Health Record;Etiology;Future;Gene Expression;generative models;Genes;Genetic Transcription;Health Services;Immune;Immunology;Immunophenotyping;Individual;Infection;Intervention;Long COVID;Machine Learning;machine learning method;Measurement;Mediating;Medical;Methodology;Methods;Modality;Modeling;Multiomic Data;multiple omics;Nature;Observational Study;pandemic disease;Patients;persistent symptom;Plasma;Play;Post-Acute Sequelae of SARS-CoV-2 Infection;Prevalence;Prevention;receptor;Recording of previous events;Recovery;Reporting;response;Role;SARS-CoV-2 infection;Scientist;secondary analysis;severe COVID-19;Severity of illness;Signs and Symptoms;Symptoms;Systems Biology;T-cell receptor repertoire;T-Lymphocyte;therapeutic target;Thymus Gland;Time;tool;Vaccination;vaccine development;Vaccines;Variant;Viral;Viremia;Virus;Work

PROJECT_TITLE: Modeling the dynamics and composition of T-cell receptor repertoires in post-acute sequelae of COVID-19 (PASC)

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Using a community based participatory research approach, we will recruit 1000 individuals from the Somali community in Southeast Minnesota to create a biorepository of plasma, DNA, and RNA. We will perform whole genome sequencing to assess demographic history, calculate polygenic scores and identify and return medically actionable variants to participants. Participants may benefit from learning about their genetic predisposition to disease and receiving timely treatment to reduce risk. By bringing genomic medicine to an understudied population, the proposed work aims to reduce disease burden and lessen health disparities.

PI_NAMEs: KULLO, IFTIKHAR J (contact)

PROGRAM_OFFICER_NAME: CHANG, CHRISTINE Q

PROJECT_TERMS: actionable mutation;Admixture;Advisory Committees;Africa;African;African ancestry;American;Anatomy;Applications Grants;biobank;Body mass index;burden of illness;Capital;Cardiometabolic Disease;Catalogs;causal variant;Central Africa;Clinical;cohort;Collection;Communities;community advisory board;community based participatory research;community engagement;community organizations;Country;Data;data sharing;dietary;Disease;Disparity;DNA;Elderly;Electronic Health Record;Emigrations;Equity;Ethnic Population;expectation;experience;Family;Famines;Feedback;Funding;Gene Frequency;Genes;Genetic;genetic analysis;genetic information;Genetic Predisposition to Disease;genetic variant;Genome;genome sequencing;Genomic medicine;genomic variation;Genomics;geographic difference;Graph;Health;health disparity;Health Personnel;Health Surveys;Height;Historical Demography;Horns;Human;Individual;Informed Consent;Infrastructure;insight;interest;Knowledge;Learning;lifestyle factors;Linkage Disequilibrium;Lipids;Manuals;Medical;Medical Genetics;medical schools;Methods;migration;Minnesota;Minority Groups;Modernization;Natural Selections;new therapeutic target;novel;Outcome;pan-genome;Participant;Pattern;Pharmacogenomics;Plasma;Politics;Population;Population Genetics;Population Group;Population Heterogeneity;programs;racial population;Rare Diseases;Recording of previous events;recruit;reference genome;Research;Research Priority;Resources;Rest;Risk Factors;Risk Reduction;RNA;Series;Shapes;Signal Transduction;social health determinants;Social Workers;Somalia;Southern Africa;Structure;Surveys;trait;Tribal Elders;Twin Cities;underserved minority;Underserved Population;United States;Variant;War;Western Africa;whole genome;Woman;Work;Youth

PROJECT_TITLE: GEMINEA: Genomic Medicine for Individuals from East Africa

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (O1)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Stroke

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE A deeper understanding of injury processes in spontaneous intracerebral hemorrhage (ICH), a severe form of hemorrhagic stroke for which there are no effective treatments, is critical. Through serum, plasma, and cerebrospinal fluid measures of maladaptive neutrophil inflammation (neutrophil extracellular traps, NETs), transendothelial neutrophil migration (soluble intercellular adhesion molecule-1), and brain tissue injury (neurofilament light chain, NfL), and by using an innovative high-resolution brain MRI approach in a prospective cohort of patients with ICH, the goal of this proposal is to acquire expertise in biomarker validation, clinical study conduct, and the use of imaging markers as endpoints in clinical trials in patients with ICH. This proposal will identify the contribution of NETs to local (edema) and remote (ischemic lesions) tissue injury, both associated with poor outcome after ICH, which may define novel treatment targets for patients with ICH, at the level of neutrophil migration, activation, or generation of NETs (NETosis).

PI_NAMEs: WITSCH, JENS JULIAN (contact)

PROGRAM_OFFICER_NAME: DALEY, WILLIAM PATRICK

PROJECT_TERMS: 3-Dimensional;Academia;Acute;Address;Admission activity;Age;Animal Model;Anti-Inflammatory Agents;Autopsy;Biochemical;Biological Markers;biomarker validation;Blinded;Blood;Blood - brain barrier anatomy;Blood Pressure;Brain;Brain hemorrhage;Brain Ischemia;brain magnetic resonance imaging;brain tissue;career;Cerebral hemisphere hemorrhage;Cerebral Ischemia;cerebral microbleeds;Cerebrospinal Fluid;Cessation of life;Clinical Research;Clinical Trials;Clinical Trials Design;Complex;Conduct Clinical Trials;Data;Diffusion Magnetic Resonance Imaging;disability;disabled;Disease;DNA;Edema;effective therapy;Endothelium;Event;extracellular;Extravasation;Future;Gatekeeping;Generations;Goals;Hemorrhage;Histology;Histones;Hospitalization;Hospitals;Hour;Image;imaging biomarker;Industry;Infarction;Infiltration;Inflammation;Injury;Innate Immune Response;innovation;Intercellular adhesion molecule 1;International;Ischemia;ischemic lesion;Ischemic Stroke;Length of Stay;Lesion;Leukoaraiosis;Light;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Measurement;Measures;Mediating;Mediator;Mentors;Microvascular Dysfunction;migration;Modeling;molecular marker;mortality;Nervous System Disorder;neurofilament;neuroimaging;neuron loss;Neuronal Injury;neutrophil;novel;novel therapeutics;observational cohort study;Outcome;Outcome Measure;Participant;pathogen;Patient Recruitments;Patients;Pennsylvania;Peroxidases;Pharmaceutical Preparations;Plasma;prevent;Process;prospective;Prospective cohort;Prospective Studies;Proteins;recruit;Reporting;Research;Resolution;response;Sample Size;Scientist;Serum;Severities;Stroke;Subarachnoid Hemorrhage;success;Survivors;Symptoms;Testing;Therapeutic;therapeutic target;Thrombosis;Thrombus;Time;tissue injury;Tissues;TRAP Complex;treatment trial;trial design;Universities;usability;Work

PROJECT_TITLE: Neutrophil extracellular traps and high-precision MRI measures of tissue injury after intracerebral hemorrhage

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Lung;Rare Diseases

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: The acute respiratory distress syndrome (ARDS) is a common, often fatal, inflammatory lung injury for which there are limited therapeutic options. In this proposal, I leverage my recent work highlighting neutropenic ARDS as a high endothelial stress population to propose studies that test the hypothesis that “neutropenic inflammation” activates the endothelium toward programmed cell death and the protective role of endothelial necrotic cell death protein receptor interacting protein kinase-3 (RIPK3) in this inflammatory environment. Collectively, these studies will provide novel insight into pathways of neutropenic inflammation and endothelial RIPK3 in regulating vascular injury in ARDS.

PI_NAMEs: PRICE, DAVID REGAN (contact)

PROGRAM_OFFICER_NAME: KALANTARI, ROYA

PROJECT_TERMS: Acute;Acute Lung Injury;Acute Respiratory Distress Syndrome;Angiopoietin-2;ANGPT2 gene;Apoptosis;Attenuated;Biological Markers;Biology;Blood Vessels;career development;cecal ligation puncture;Cell Death;Cell Death Induction;Cells;Clinical;cohort;cytokine;Data;Development;Disease;Endothelial Cells;Endothelium;Environment;experimental study;Family;Fluorouracil;Future;Gene Silencing;Gene Targeting;Goals;Human;human data;ICAM1 gene;Immune;In Vitro;in vivo;indexing;Inflammation;Inflammatory;inflammatory milieu;Injury;Innate Immune Response;insight;Intercellular adhesion molecule 1;Interleukin-6;Investigation;Knock-out;Link;Lung;lung injury;lung vascular injury;Measures;Mediating;Mediator;Medicine;Mentorship;Methods;Modeling;mortality;mouse model;Mus;Necrosis;Neutropenia;neutrophil;novel;Organoids;Pathogenesis;Pathway interactions;Patients;Perfusion;Permeability;Phenocopy;Phosphotransferases;Physicians;Plasma;Population;Positioning Attribute;Price;professor;Program Development;Protein Kinase Interaction;Proteins;receptor;Receptor-Interacting Protein;Regulation;Research;Respiratory Failure;response;response to injury;Role;Scientist;Sepsis;Serine;Severity of illness;Signal Transduction;skills;Stress;Testing;Therapeutic;Threonine;TNFRSF1A gene;Training;vascular injury;Vascular Permeabilities;vascular stress;Work

PROJECT_TITLE: Protective role of Endothelial Receptor Interacting Protein Kinase 3 (RIPK3) in acute lung injury

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (OA)]


NIH_SPENDING_CATS: Cancer;Cervical Cancer;Infectious Diseases;Prevention;Sexually Transmitted Infections;Women's Health Research

ORG_DEPT: OTOLARYNGOLOGY

PHR: PROJECT NARRATIVE High-risk human papillomavirus infections cause cervical cancer and other genital and oropharyngeal cancers that account for nearly 5% of cancers worldwide. HPV-positive cancers develop following long-term persistent HPV infections in which infected cells are retained in the proliferative basal layer of stratified epithelia. The goal of this proposal is to use a robust engineered tissue assay to test whether specific activities of HPV E6 and E7 oncoproteins from mucosal and cutaneous virus genotypes drive cell retention in the basal epithelial layer.

PI_NAMEs: WHITE, ELIZABETH A (contact)

PROGRAM_OFFICER_NAME: ALARCON, RODOLFO M

PROJECT_TERMS: 3-Dimensional;Basal Cell;Benign;Binding;Binding Proteins;Biological Assay;Biology;carcinogenesis;Cell Culture Techniques;Cell Differentiation process;Cell Maintenance;Cells;cellular targeting;Chromatin;chronic infection;Clinical;Cutaneous;Data;Detection;Disease;Engineering;Epithelial Cell Proliferation;Epithelial Cells;Epithelium;Event;Genetic Transcription;Genitalia;Genome;Genotype;Goals;high risk;HPV E7;HPV positive;HPV-High Risk;Human;Human Activities;Human papilloma virus infection;Human Papillomavirus;Human papillomavirus 16;Immune Evasion;Impairment;inhibitor;keratinocyte;Lesion;Malignant neoplasm of cervix uteri;Malignant Neoplasms;malignant oropharynx neoplasm;Mediating;migration;Modeling;Mucous Membrane;mutant;notch protein;NOTCH1 gene;novel therapeutic intervention;Oncoproteins;Papillomavirus;Pathogenicity;Pathway interactions;Physiological;premalignant;prevent;Prevention;programs;Proteins;Publishing;recruit;Repression;response;risk variant;Signal Pathway;Signal Transduction;Stimulus;Stratified Epithelium;Stratified Squamous Epithelium;Stratum Basale;Technology;Testing;three-dimensional modeling;Tissue Engineering;Tissue Model;Tissues;TP53 gene;Tropism;tumor;Tumor Suppressor Proteins;two-dimensional;ubiquitin ligase;Viral;virology;Virus;virus host interaction;Work

PROJECT_TITLE: Establishment of basal epithelial identity by papillomavirus oncoproteins

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Immunization;Infectious Diseases;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NORTH CHICAGO

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ROSALIND FRANKLIN UNIV OF MEDICINE & SCI

ORG_STATE: IL

PHR: Narrative Infections with encapsulated bacteria are responsible for the death of millions of children and the elderly each year. The efficacy of vaccines against these pathogens is severely limited by their inability to induce recall responses upon revaccination or infection. We will use a mouse model to improve vaccination against one of these bacterial infections and create proof of concepts that can inform future development of more effective vaccination strategies.

PI_NAMEs: RE, FABIO C (contact)

PROGRAM_OFFICER_NAME: CASTLEMAN, MORIAH JOVITA

PROJECT_TERMS: adaptive immune response;Adjuvant;Adjuvant Therapy;Antibodies;Antibody Formation;Antigen-Antibody Complex;Antigens;B-Cell Activation;B-Lymphocytes;Bacteria;Bacterial Infections;Bacterial Polysaccharides;Biology;Carbohydrates;Carrier Proteins;cell type;Cells;Cellular biology;Cessation of life;Child;Classification;Complement;Complement Activation;cytokine;Data;Development;Elderly;Encapsulated;experimental study;Francisella;Francisella tularensis;Future;Generations;Goals;Gram-Negative Bacteria;Human;IgG3;Immune response;Immunization;Immunoglobulin A;Immunoglobulin Class Switching;Immunoglobulin G;Immunoglobulin M;Immunoglobulin Switch Recombination;Immunologist;improved;Infection;Inflammatory;Innate Immune Response;Interleukin-5;Lymphoid Cell;Memory;Memory B-Lymphocyte;Modeling;mouse model;novel;pathogen;Peritoneal;Play;Polysaccharides;Process;Production;Publishing;receptor;response;Role;Route;Structure;T-Cell Activation;T-Independent Antigens;Testing;Tularemia;Vaccination;vaccination strategy;vaccine development;vaccine efficacy;vaccine failure;Vaccines

PROJECT_TITLE: Improving vaccination against type-2 T-independent antigens

STUDY_SECTION: VID

STUDY_SECTION_NAME: Vaccines Against Infectious Diseases Study Section[VID]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Psychosis;Schizophrenia;Serious Mental Illness

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Autism spectrum disorder (ASD) is a phenotypically heterogeneous entity with a broad range of possible clinical presentations and trajectories and a complex genetic architecture that includes multiple rare variants of large effect. This project investigates key domains of cognition and psychopathology in a subgroup of individuals with ASD who have rare genetic variants that are also associated with schizophrenia (SCZ), elucidating the underlying patterns of risk and emergence of co-occurring mental health problems in individuals with ASD.

PI_NAMEs: JUTLA, AMANDEEP  (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TERMS: Address;Affect;autism spectrum disorder;Caring;Characteristics;Clinical;clinical heterogeneity;Cognition;Cognitive;cognitive control;cognitive neuroscience;cognitive system;cohort;Complex;Computer Models;Data;Data Analyses;Development;Diagnosis;Diagnostic;Disease;DSM-V;endophenotype;Ethics;executive function;expectation;Genes;Genetic;genetic architecture;Genetic Heterogeneity;Genetic Research;genetic variant;Genotype;Heritability;Heterogeneity;Impaired cognition;Impairment;Individual;individuals with autism spectrum disorder;insertion/deletion mutation;Intervention;Knowledge;legal implication;Mental disorders;Mental Health;neural circuit;Neurodevelopmental Disorder;Outcome;Parents;Participant;Patient Self-Report;Pattern;Perceptual disturbance;Phenotype;polygenic risk score;Psychopathology;Psychoses;psychotic-like experiences;rare variant;remote assessment;repetitive behavior;Reporting;Research;Research Domain Criteria;Resistance;Risk;risk sharing;Sampling;Schizophrenia;schizophrenia risk;schizophrenia spectrum disorder;Sensory;Severities;social;Social Behavior Disorders;social implication;Stereotyped Behavior;Subgroup;Techniques;Testing;Time;Training;Variant;Work

PROJECT_TITLE: A Genetics-First Approach to Shared Risk in Neurodevelopmental Disorders

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


NIH_SPENDING_CATS: Diabetes;Genetics;Human Genome;Obesity

ORG_CITY: ORLANDO

ORG_NAME: ADVENTHEALTH ORLANDO

ORG_STATE: FL

PHR: PROJECT NARRATIVE Skeletal muscle insulin resistance is one of the contributing factors to the development of Type 2 Diabetes; however, skeletal muscle is a complex tissue comprised of multiple cell types and masses of myonuclei, making it difficult to pinpoint where these aberrations occur. This project aims to uncover which cells and which areas of skeletal muscle are dysregulated in skeletal muscle insulin resistance in Type 2 Diabetes. This information will be used to design therapeutic interventions to alleviate skeletal muscle insulin resistance.

PI_NAMEs: WHYTOCK, KATIE  (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Adipose tissue;Adult;Affect;Age;Applications Grants;Archives;Area;arteriole;bench to bedside;bench-to-bedside translation;Bioinformatics;bioinformatics pipeline;Biopsy;Blood Vessels;Body mass index;Capillary Endothelial Cell;career;career development;Cell Nucleus;cell type;Cells;Clinical Research;Closure by clamp;Collaborations;collaborative environment;Complex;complex data;Data Set;design;Development;Dissociation;Doctor of Philosophy;Endothelial Cells;Environment;experimental study;Fatty acid glycerol esters;feeding;Fibroblasts;Fingerprint;Foundations;Freezing;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene network;Genes;Genetic Transcription;Glucose;Glucose Clamp;glucose disposal;glucose metabolism;glucose uptake;Human;Hyperinsulinism;Immune;Impairment;improved;in vivo;Indirect Calorimetry;Individual;innovation;Insulin;Insulin Resistance;insulin sensitivity;insulin signaling;Leadership;Learning;Length;Measures;Mentors;Metabolic;method development;Molecular;Molecular Profiling;Molecular Target;Mononuclear;Muscle;Muscle Fibers;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Participant;Perfusion;Peripheral;Phase;Population;Positioning Attribute;Prevention;Protocols documentation;Research;research and development;research facility;Research Institute;Research Personnel;Resolution;response;Role;Sampling;sex;Signal Transduction;single nucleus RNA-sequencing;single-cell RNA sequencing;Skeletal Muscle;skeletal muscle metabolism;skills;Smooth Muscle Myocytes;success;Techniques;Technology;Therapeutic Intervention;Thinness;Time;Tissues;Tracer;Training;transcriptome;transcriptomics;Translational Research;translational scientist

PROJECT_TITLE: Determining cell- and spatially-distinct skeletal muscle transcriptional aberrations in insulin resistance and type 2 diabetes


NIH_SPENDING_CATS: Biomedical Imaging;Cardiovascular;Clinical Research;Dissemination and Implementation Research;Emergency Care;Heart Disease

ORG_DEPT: EMERGENCY MEDICINE

PHR: Project Narrative Despite much research in this area, cardiac arrest remains one of the leading causes of death and an important cause of neurological disability in the U.S, suggesting the crucial need to seek innovative strategies to improve resuscitation outcomes. This re-submission K23 proposal aims to understand the physiology, impact in clinical outcomes, and the determinants of implementation success of a new resuscitation strategy involving the integration of transesophageal echocardiography (TEE), aimed to improve the efficacy of cardiopulmonary resuscitation in cardiac arrest patients. If successful, this novel approach has the potential to transform resuscitation care and improve clinical outcomes for cardiac arrest.

PI_NAMEs: TERAN MERINO, FELIPE  (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Accident and Emergency department;acute care;Adult;Anatomy;Area;Blood Vessels;Carbon Dioxide;Cardiac;Cardiopulmonary Resuscitation;Cardiovascular Physiology;Cardiovascular system;career development;Caring;Cause of Death;Characteristics;Chest;Circulation;Classification;Clinical;clinical effect;clinical investigation;Clinical Research;Consolidated Framework for Implementation Research;Critical Care;Data;Development;Development Plans;Diastolic blood pressure;dissemination science;Effectiveness;Elements;Evaluation;experience;Focus Groups;Future;Group Interviews;Guidelines;Heart Arrest;heart imaging;heart visualization;hemodynamics;Hospitals;Image;implementation determinants;implementation intervention;implementation science;improved;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Laboratories;Laboratory Study;Left;Left Ventricular Outflow Obstruction;Left ventricular structure;Location;Measures;Mentors;Mentorship;Methods;Modality;multidisciplinary;Nervous System Trauma;Neurological disability;Neurological outcome;novel;novel diagnostics;novel strategies;observational cohort study;Obstruction;out-of-hospital cardiac arrest;Outcome;Output;patient oriented research;Patient-Focused Outcomes;Patients;Performance;Persons;Physicians;Physiological;Physiology;Positioning Attribute;Pragmatic clinical trial;primary outcome;Procedures;Process;prospective;quality assurance;Radiology Specialty;Recommendation;Registries;Research;research and development;Research Infrastructure;Research Personnel;Resuscitation;Sampling;Science;Scientist;skills;Sternum;Structure;success;Surveys;survival outcome;Survivors;Time;Training;Transesophageal Echocardiography;United States National Institutes of Health;Ventricular;Visualization;Work

PROJECT_TITLE: The Use of Transesophageal Echocardiography to Improve Cardiac Arrest Resuscitation Care

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (OA)]


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Dystonia;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Parkinson's Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: Project narrative A central role for lysosomal dysfunction has been highlighted for neurodegenerative disease mechanisms across multiple genetic forms of movement disorders, including Parkinson disease (PD) and dystonia. The proposed research will investigate the function of BORCS5, a lysosomal gene that we recently identified as a novel genetic cause of neurodegeneration with parkinsonism and dystonia. The project will reveal mechanistic insights into the role of BORCS5 in regulating the complex interplay of lysosomal intracellular dynamics, maturation and degradative properties with the goal of identifying novel therapeutic angles for targeting lysosomal dysfunction in neurodegenerative disorders.

PI_NAMEs: MENCACCI, NICCOLO E (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: Affect;Alleles;alpha synuclein;Autophagocytosis;Autophagosome;Award;Axon;Biological Assay;Biology;career;career development;Cell Line;Cells;Childhood;clinically relevant;Complex;Coupled;Data;Defect;Development Plans;Disease;disease model;disease-causing mutation;Distal;Dopamine;dopaminergic neuron;Dystonia;early onset;Enzymes;Event;Fibroblasts;Foundations;Functional disorder;Genes;Genetic;genetic manipulation;glucosylceramidase;Goals;Homeostasis;Human;human disease;human induced pluripotent stem cells;Impairment;induced pluripotent stem cell;insight;Kinesin;Knock-out;Link;live cell microscopy;Lysosomes;Mammalian Cell;Mediating;member;Midbrain structure;Modeling;Molecular;Morphology;Movement;Movement Disorders;mutant;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurologist;Neuronal Dysfunction;Neurons;Neurosciences;novel;novel therapeutics;Parkinson Disease;Parkinsonian Disorders;Pathogenesis;Pathogenicity;Pathologic;Pathology;Patients;Pattern;Phenotype;Physiological;Positioning Attribute;Property;receptor;Recurrence;Recycling;Research;research and development;Research Personnel;Rodent;Role;Structure;Symptoms;Synapses;Synaptic Vesicles;System;Techniques;temporal measurement;Therapeutic;Time;trafficking;Training;Variant;Vesicle

PROJECT_TITLE: Understanding the role of BORCS5 in neuronal lysosomal function and neurodegeneration


NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Contraception/Reproduction;Estrogen;Headaches;Neurosciences;Pain Research;Pediatric;Women's Health Research

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

PHR: PROJECT NARRATIVE In 2016, almost 3 billion people worldwide were estimated to have a headache disorder, the majority of whom were women. This sex difference starts in puberty, a time when neuroimaging has demonstrated brain changes driven by pubertal hormones. Through focus on transmasculine youth, the proposed longitudinal observational study will use neuroimaging techniques to explore the role of pubertal hormones in the development of sex differences in headache and relevant brain structure and function, with the vision of identifying targets for future therapies to reduce risk of headache.

PI_NAMEs: HRANILOVICH, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: OSHINSKY, MICHAEL L

PROJECT_TERMS: Address;Adolescence;Adolescent;Adolescent and Young Adult;Adult women;Age;Age of Onset;Agonist;Algorithms;Amygdaloid structure;Animal Model;antinociception;Anxiety;assigned female at birth;Biological Models;Biometry;Birth;boys;Brain;Breathing;career development;Childhood;cisgender;Clinical;clinical database;Clinical Research;Code;cohort;Colorado;Cross-Sectional Studies;Data Set;Databases;design;Development;Diagnosis;Diagnostic;diaries;Disability scale;disability-adjusted life years;Electronics;Estrogens;experience;falls;Female;Feminization;follow-up;Functional Magnetic Resonance Imaging;Funding;Future;gender affirming hormone therapy;gender diversity;Gender Identity;girls;Gonadal Steroid Hormones;Gonadotropin Hormone Releasing Hormone;Headache;Headache disability;Headache Disorders;Health;health record;Hormonal;Hormones;Hospitals;Human;human subject;improved;Informatics;innovation;Learning;Libido;Life;Longitudinal, observational study;male;Male Adolescents;Masculine;medical schools;men;Mental Depression;Methods;Modeling;Multicenter Studies;neuroimaging;Neurologic;Nociception;novel strategies;Observation in research;Outcome;Pain;pediatric department;Pediatric Hospitals;Pediatric Neurology;Persons;Pharmaceutical Preparations;Physiological;Population;pressure;Prevalence;Prevention;professor;prognostication;prospective;Puberty;recruit;Research;Research Personnel;Research Proposals;response;Rest;Risk;Risk Reduction;Rodent;Role;Scientist;Sensory;Serum;sex assigned;sex development disorder;Sex Differences;Sex Differentiation;skill acquisition;skills;structural imaging;Structure;Study models;Techniques;Testosterone;Time;Training;transfeminine;transgender;Translational Research;Translations;transmasculine;Universities;validation studies;Vision;Woman;Women's cohort;Women's study;Youth

PROJECT_TITLE: Effect of pubertal hormones on Headache in Transmasculine Adolescents


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Congenital Structural Anomalies;Epilepsy;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences;Pediatric;Rare Diseases

ORG_DEPT: NEUROSURGERY

PHR: Project Narrative Childhood epilepsy is a common and often devastating disease, and chronic seizures lead to a significant increase in premature mortality and developmental delay. A substantial proportion of children with Malformations of Cortical Development (MCDs) experience medically and surgically refractory seizures. This project will determine whether elongated axons, caused by known genetic changes, directly contribute to the untreatable seizures in children with MCDs and are thus a potential therapeutic target.

PI_NAMEs: ALEXANDER, ALLYSON LAURA (contact)

PROGRAM_OFFICER_NAME: UMANAH, GEORGE KWABENA ESSIEN

PROJECT_TERMS: 3-Dimensional;Affect;Animal Model;Award;Axon;axonal degeneration;biocytin;Biological;Brain;Calcium;career;career development;Cells;Cementation;Chairperson;Child;Childhood;childhood epilepsy;Chronic;Climacteric;Clinical;Colorado;computer studies;Cortical Dysplasia;Cortical Malformation;Data;Dedications;Defect;Development;Development Plans;Developmental Delay Disorders;Disease;Electroencephalography;Electrophysiology (science);Electroporation;Epilepsy;Equipment;Excision;excitatory neuron;Exhibits;experience;experimental study;FRAP1 gene;Frequencies;Functional disorder;Future;gain of function mutation;Generations;Genes;genetic approach;Goals;Growth;hemimegalencephaly;hippocampal pyramidal neuron;Human;human tissue;Image;in utero;In Vitro;in vivo;Individual;inhibitory neuron;Interleukin Receptor;Intractable Epilepsy;Label;Laboratories;laboratory equipment;Laboratory Personnel;Lead;Leadership;Length;Life;malformation in cortical development;Medical;Mentors;Mentorship;method development;Molecular;mouse model;Mus;Mutation;neuronal cell body;neuronal growth;Neurons;Neurosciences;Neurosurgeon;Operative Surgical Procedures;patch clamp;Pathway Analysis;Pathway interactions;Patients;Pediatric Hospitals;Photons;Physicians;Physiology;Pre-Clinical Model;Premature Mortality;programs;Proliferating;Proteins;Pyramidal Cells;Qualifying;reconstruction;Refractory;Research;Research Personnel;Resources;Rodent;Scientist;Seizures;Signal Transduction;Slice;Synapses;Synaptic plasticity;Techniques;Testing;therapeutic target;Time;Training;Tuberous Sclerosis;Up-Regulation;Viral;Work

PROJECT_TITLE: Getting Excited about Cortical Malformations: Discovering the Mechanisms Leading to Seizure-prone Neurons in Malformations of Cortical Development


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Digestive Diseases

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative: Pathophysiology of gastrointestinal motor function underlies numerous disorders of gastrointestinal system, for example, gastroparesis. In this project, we will develop novel magnetic resonance imaging (MRI) methods for imaging the dynamic motor processes with at a high frame rate and in high resolution, all in the presence of respiratory and other motion. The success of this project will lead to an improved imaging methods to help visualize gastric motor function, enhancing the physiological understanding of a variety of gastrointestinal disorders.

PI_NAMEs: NOLL, DOUGLAS C (contact)

PROGRAM_OFFICER_NAME: BARRY, ROBERT LEO II

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Antral;automated segmentation;Behavior;Blinded;Breathing;Characteristics;Clinic;Clinical;Complex;contrast enhanced;design;Diabetes Mellitus;Diagnosis;Digestion;Digestive System Disorders;Dimensions;Disease;Duodenum;Dyspepsia;effective therapy;Event;Four-dimensional;Frequencies;Functional disorder;Gastric Emptying;Gastroesophageal reflux disease;gastrointestinal;Gastrointestinal Diseases;gastrointestinal function;gastrointestinal imaging;gastrointestinal system;Gastrointestinal tract structure;Gastroparesis;Goals;healthy volunteer;Homeostasis;Image;image reconstruction;Imaging Device;imaging modality;Impairment;improved;Ingestion;Intestinal Motility;Intestines;Label;Location;Magnetic Resonance Imaging;Measures;Metabolic Diseases;Methods;Modeling;Motility;motility disorder;Motion;Motor;Movement;Names;Nausea;Noise;novel;novel strategies;nutrient absorption;Obesity;object motion;Organ;Pattern;Performance;Phase;Physiological;Population;Process;Pylorus;Radioactive;reconstruction;Reproducibility;Resolution;Respiration;respiratory;Scanning;Services;Signal Transduction;spatiotemporal;Speed;Stomach;Structure;success;Symptoms;temporal measurement;Time;tool;treatment planning;Upper digestive tract structure;Visualization;volunteer;Vomiting

PROJECT_TITLE: Novel methods for dynamic MRI of gastrointestinal motor function

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Mental Health;Mental Illness;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: PROJECT NARRATIVE Depression is an independent risk factor for hypertension, and promising evidence suggests that treating depression can improve blood pressure control. This study will develop a community-informed intervention and implementation approach to treat depression among African American adults with comorbid depression and hypertension living on the South Side of Chicago. Results will inform public health efforts to widely disseminate depression interventions to promote blood pressure control among populations with significant cardiovascular disease disparities.

PI_NAMEs: CARROLL, ALLISON JANE (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Adherence;Adult;Affect;African American;African American population;Anti-Hypertensive Agents;Applications Grants;Area;Behavior Therapy;behavioral health;behavioral health intervention;Behavioral Sciences;blood pressure control;Cardiac;Cardiovascular Diseases;cardiovascular health;career;Characteristics;Chicago;Church;Clinic;clinical care;Collaborations;Communities;community collaboration;community engaged intervention;community engaged research;community intervention;community partners;comorbid depression;comorbidity;Consolidated Framework for Implementation Research;contextual factors;Crime;culturally appropriate intervention;Data;density;depressive symptoms;Development;Discrimination;disease disparity;Disease Outcome;Disparity;Economic Factors;Effectiveness;effectiveness outcome;effectiveness/implementation study;Equity;Evaluation;evidence base;Evidence based intervention;experience;Faith;follow-up;Funding;Goals;Health;Health Care Costs;health disparity;Health Services;Hypertension;implementation context;implementation facilitators;implementation intervention;implementation outcomes;implementation protocol;implementation science;improved;Individual;Institutional Racism;Intervention;Knowledge;Leadership;Lived experience;Measures;Medical;Medical Records;medical schools;medication compliance;member;Mental Depression;Mentored Patient-Oriented Research Career Development Award;Mentorship;Methodology;Methods;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Neighborhoods;Not Hispanic or Latino;Outcome;patient engagement;Pharmaceutical Preparations;pilot test;pilot trial;Population;Population Intervention;prevent;Protocols documentation;Psychiatry;Public Health;Public Health Informatics;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Personnel;Research Project Grants;Resources;Risk Factors;Safety;Side;skills;social stigma;Source;Specificity;statistics;surveillance data;Testing;tool;Training;Transportation;United States;Universities

PROJECT_TITLE: Addressing Depression for African American Adults with Hypertension: Applying Community-Engaged Implementation Science


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cannabidiol Research;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Endocannabinoid System Research;Mental Health;Natural Products;Substance Misuse

ORG_CITY: Boulder

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF COLORADO

PHR: Project Narrative Using cannabis for coping purposes is a problematic use pattern with negative health implications (e.g., greater quantity/frequency of cannabis use), and this behavior has potential for increase due to spreading cannabis legalization. The current project proposes to test several relationships relevant to this use pattern including causal factors, potential outcomes, and what variables may moderate/mediate the relationship between cannabis use and stress. Knowledge from this research can have significant impact on public health via aiding in intervention and prevention efforts as well as gaining information on the harm reduction potential of specific cannabinoid content.

PI_NAMEs: SKRZYNSKI, CARILLON JOY (contact)

PROGRAM_OFFICER_NAME: FEDOTA, JOHN RAPHAEL

PROJECT_TERMS: Acute;acute stress;Alcohol consumption;anandamide;Anxiety;Behavior;behavioral outcome;Biological;biological adaptation to stress;Biological Markers;biological systems;Cannabidiol;Cannabinoids;Cannabis;Cognitive;coping;COVID-19 pandemic;Data;discounting;Emotional;Endocannabinoids;endogenous cannabinoid system;Experimental Designs;experimental study;Frequencies;Future;Harm Reduction;Health;Human;Hydrocortisone;Individual;Individual Differences;Intervention;Knowledge;Longitudinal Studies;Marijuana Dependence;marijuana legalization;marijuana use;Measures;Mediating;Mental Depression;Mental Health;Outcome;outcome disparities;Participant;Patient Self-Report;Pattern;perceived stress;physical conditioning;Physiological;Prevention;Process;Production;Psyche structure;psychological outcomes;Public Health;Reporting;Research;Research Support;Risk;Role;Safety;social;social anxiety;Stress;Stress and Coping;stress reduction;Testing;Tetrahydrocannabinol

PROJECT_TITLE: Exploring the antecendents and consequences of cannabis use in the context of coping: An experimental study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative GPR56, an adhesion G-protein coupled receptor, was recently identified as upregulated in microglia in individuals with early-stage Alzheimer's disease (AD) compared to those with no pathology or late-stage AD, implying its potential function in the disease. In this proposal, I hypothesize that microglial GPR56 limits AD pathological progression in both AD mouse models and human patients. I will use cutting-edge techniques, including single-cell sequencing, mouse genetics, live imaging, and human brain tissues, to reveal the role of microglial GPR56 in AD pathology, shedding light on a novel therapeutic target for AD.

PI_NAMEs: ZHU, BEIKA  (contact)

PROGRAM_OFFICER_NAME: OPANASHUK, LISA A

PROJECT_TERMS: Actins;ADGR1 gene;Adhesions;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Amyloid deposition;Astrocytes;Autophagocytosis;Autopsy;Bone Marrow;Brain;brain control;Brain Diseases;brain tissue;Cells;clinical diagnosis;Cohort Studies;Communities;conditional knockout;Control Animal;cytokine;Data;Dementia;Deposition;Disease;Disease Progression;disorder control;effective therapy;Elderly;Equilibrium;Excision;Fetal Liver;G-Protein-Coupled Receptors;Genes;High Prevalence;Homeostasis;Human;human disease;human tissue;Image;Immunohistochemistry;Impairment;in vivo;Individual;Inflammatory;Knock-out;Knockout Mice;Knowledge;Label;Lateral;Light;Literature;Maintenance;Memory;Microglia;mild cognitive impairment;Molecular;motor learning;mouse genetics;mouse model;Mus;Nerve Degeneration;Neurodegenerative Disorders;neurodevelopment;Neurofibrillary Tangles;Neuroglia;Neuroimmune;neuron loss;Neurons;new therapeutic target;novel;Occipital lobe;old mice;Participant;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Pattern;Phase;Phenotype;Plague;Play;prevent;Property;protein aggregation;Protein Analysis;Public Health;religious order study;Research;response;Role;Sampling;Senile Plaques;Signal Transduction;single cell sequencing;single nucleus RNA-sequencing;Slice;spatial memory;Structure of middle temporal gyrus;success;Tamoxifen;tau Proteins;Techniques;Testing;Therapeutic;Time;Transcript;transcriptomics;treatment comparison;virtual;Yolk Sac

PROJECT_TITLE: GPCR-dependent microglial function in Alzheimer's disease

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Project Narrative Becoming a successful translational scientist in the field of international infectious diseases is challenging, requiring extensive training in leading field studies, developing and performing laboratory assays, and synthesizing and interpreting the data generated. This K24 renewal will provide Dr. Greenhouse protected time for mentoring and career development, allowing him to help train the next generation of scientists in this area, drawing upon his broad expertise and established research program. He will focus on leadership development, expand the scope of his research portfolio beyond malaria, and establish an interactive, online training platform in genomic epidemiologic analysis.

PI_NAMEs: GREENHOUSE, BRYAN R (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;acquired immunity;Address;African;Algorithms;analytical method;Anti-malarials;Area;Award;Bioinformatics;Biological Assay;Biometry;Birth;Blood;burden of illness;career;Career Choice;career development;Case Management;Centers of Research Excellence;Circulation;Cities;Classification;Clinical;cohort;Collaborations;Communicable Diseases;Communication;Communities;Community Health;Computer Analysis;Computerized Medical Record;Country;COVID-19 pandemic;Data;Data Analyses;Data Science;Dedications;Development;disease transmission;Educational process of instructing;Educational workshop;efficacy study;Enrollment;Epidemiology;epidemiology study;experience;Fever;field study;flexibility;Funding;Future;Generations;genetic epidemiology;genomic epidemiology;Geography;Goals;Grant;Growth;Guidelines;Health;Health care facility;Household;Immigrant;Immigrant community;Immunity;Immunology;improved;improved outcome;Income;infection burden;Infectious Disease Epidemiology;Infectious Diseases Research;Infrastructure;interdisciplinary approach;interest;Internal Medicine;International;Intervention;K-Series Research Career Programs;Laboratories;leadership development;Learning;Longitudinal Studies;Malaria;Mentors;Mentorship;Metagenomics;method development;Methods;Mid-Career Clinical Scientist Award (K24);Midcareer Investigator Award in Patient-Oriented Research;National Institute of Allergy and Infectious Disease;next generation;next generation sequencing;novel strategies;Paper;pathogen;patient oriented research;Peer Review;Physicians;Pilot Projects;Plasma;Population;Principal Investigator;programs;Public Health;public health intervention;Publishing;Research;Research Personnel;Residual state;Resource-limited setting;respiratory pathogen;respiratory virus;response;Risk Factors;Sampling;San Francisco;Science;Scientist;Sentinel;Sentinel Surveillance;Serology;serosurveillance;Site;skills;Specimen;success;System;Technology;Testing;Time;tool;Training;Training Programs;Translational Research;translational scientist;transmission process;Treatment Efficacy;Uganda;United States National Institutes of Health;Work

PROJECT_TITLE: Mentoring translational scientists in international infectious disease research

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases Research Study Section[MID]


NIH_SPENDING_CATS: Clinical Research;Lung;Prevention;Pulmonary Hypertension;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Despite advances in the diagnosis and treatment of pulmonary arterial hypertension, morbidity and mortality remain unacceptably high. To improve our currently limited understanding of how complex bioactive metabolite pathways interact to promote or prevent pulmonary hypertension, we will study upstream mediators of endothelial dysfunction in relation to disease risk and progression, in comprehensive study design. These studies can identify novel pathogenic and prognostic biomarkers and future therapeutic interventions.

PI_NAMEs: ALOTAIBI, MONA A (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Animal Model;Anti-Inflammatory Agents;Arachidonic Acids;career development;Cations;Cell Culture Techniques;Cells;Cessation of life;circulating biomarkers;Clinical;Clinical Management;clinical translation;Clinical Trials;cohort;Complex;Contracts;Data;data handling;Dedications;Development;Diagnosis;Disease;Disease Outcome;Disease Progression;disorder risk;Doctor of Philosophy;Eicosanoids;Endothelial Cells;endothelial dysfunction;Endothelium;Exhibits;Experimental Designs;Experimental Models;experimental study;Fostering;Future;Goals;hemodynamics;Human;Hydroxyeicosatetraenoic Acids;improved;individualized medicine;Intervention;Laboratories;laboratory curriculum;laboratory experience;Laboratory Procedures;Leadership;Left;Life;lipid mediator;Lipids;Lipoxygenase;Lung;Magnetic Resonance Imaging;Mass Spectrum Analysis;Measures;Mediating;Mediator;Mentors;Metabolic;Metabolism;metabolomics;Methods;Molecular;molecular marker;Morbidity - disease rate;mortality;mouse model;novel;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;patient registry;Patients;personalized approach;Phenotype;Physicians;Piezo 1 ion channel;Play;pre-clinical;prevent;Principal Investigator;prognostic;Prognostic Marker;Program Development;Property;Prostaglandin-Endoperoxide Synthase;pulmonary arterial hypertension;Pulmonary artery structure;Pulmonary Hypertension;pulmonary vascular remodeling;pulmonary vasoconstriction;receptor;Relaxation;relaxing factor;repository;Research;Research Design;Research Personnel;right ventricular failure;Role;Scientist;Signal Transduction;skills;small molecule;Smooth Muscle Myocytes;specific biomarkers;Study models;Systems Biology;Techniques;Testing;Therapeutic;Therapeutic Intervention;Training;Training Programs;Transfection;Vascular remodeling;vasoconstriction;Vasodilation;Work

PROJECT_TITLE: Eicosanoid Pathways Underlying Disease Risk in Pulmonary Arterial Hypertension


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Telehealth;Tobacco;Tobacco Smoke and Health

PHR: PROJECT NARRATIVE Interventions to reduce e-cigarette use (nicotine vaping) among young adults is urgently needed given high prevalence of vaping in this age group, emerging vaping-related harms, and increased risk of tobacco smoking and other substance use escalation. This study innovatively capitalizes on cutting-edge methods of mobile health research to develop and pilot test a smartphone-based intervention delivering messages tailored to risky moments for vaping occurrence. This study will lay the groundwork for evidence-based innovative interventions to curb the vaping epidemic and prevent related harms among young people.

PI_NAMEs: NGUYEN, NHUNG  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: acceptability and feasibility;adaptive intervention;Address;Age;age group;Algorithms;Area;Behavior;Behavioral;California;career;career development;Cellular Phone;Clinical;Clinical Treatment;combustible tobacco;contextual factors;Counseling;craving;Data;Data Analyses;Data Collection;Data Science;Data Set;Development Plans;digital treatment;Ecological momentary assessment;efficacy evaluation;electronic cigarette use;Ensure;Environment;Epidemic;Epidemiology;epidemiology study;evidence base;Evidence based intervention;Evidence based treatment;experience;Feedback;Frequencies;Future;Genus Capra;Goals;Health;Health behavior;Health Technology;Heterogeneity;High Prevalence;high risk;Individual;innovation;Institution;interest;Intervention;Interview;K-Series Research Career Programs;Knowledge;Location;Machine Learning;machine learning method;marijuana vaping;Mentors;Methods;mHealth;mhealth interventions;Morbidity - disease rate;mortality;multidisciplinary;National Institute of Drug Abuse;Nicotine Dependence;Participant;Pattern;personalized intervention;Persons;Pharmacotherapy;Pharmacy facility;pilot test;Population;Population Heterogeneity;Populations at Risk;post intervention;prediction algorithm;predictive modeling;prevent;programs;prototype;Public Health;Qualitative Methods;reduce tobacco use;Research;Research Personnel;Research Project Grants;Resources;respiratory;Risk;Sampling;San Francisco;smoking cessation;Smoking Cessation Intervention;social;social cognitive theory;Strategic Planning;Stress;substance use;success;Surveys;tailored messaging;Techniques;Technology;Testing;therapy development;Time;Tobacco;tobacco cessation intervention;tobacco control;Tobacco smoking behavior;Tobacco use;Tobacco Use Cessation;tool;Training;Universities;user centered design;vaping;vaping nicotine;Work;young adult

PROJECT_TITLE: Developing a smartphone-based intervention targeting high-risk situations of nicotine vaping among young adults

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The proposed research is relevant to public health because acute respiratory distress syndrome (ARDS) is a serious complication of several conditions including respiratory failure from pneumonia, other infection, cancer, organ dysfunction, surgery and trauma requiring mechanical ventilation and can lead to mortality in as much as 50% of those affected. ARDS has been described for over 50 years, however its heterogeneity has precluded the identification of effective treatments, and thus categorizing the syndrome based on what signaling cascades are affected may allow for the disease to be classified into subtypes. In deciphering the subtype of ARDS that involves lung vascular function, essential for absorption of oxygen from the lungs and expulsion of carbon dioxide from the body, we may identify therapies that may not have worked for a non-differentiated population of ARDS patients.

PI_NAMEs: COSTA MONTEIRO, ANA CAROLINA  (contact)

PROJECT_TERMS: absorption;Acute Respiratory Distress Syndrome;Address;Affect;Alveolar;Angiopoietin-2;Animals;biobank;Biodistribution;Bioinformatics;Biological;Biostatistics Core;Blood;Blood Vessels;California;Carbon Dioxide;career;career development;Cell Fraction;Cell Separation;Cells;circulating biomarkers;Classification;Clinical;clinical trial recruitment;cohort;Complication;Critical Care;Data;Data Set;design;Development;Disease;Doctor of Philosophy;effective therapy;Endothelial Cells;endothelial dysfunction;Endothelium;Epithelium;experience;Functional disorder;Future;Gases;Genetic Transcription;Goals;graft dysfunction;Heterogeneity;Human;hypoperfusion;individualized medicine;Infection;Inflammatory Response;Injury;innovation;insight;Intervention Studies;Knowledge;large datasets;Lobar;Los Angeles;Lung;Lung Diseases;lung injury;Malignant Neoplasms;Measures;Mechanical ventilation;Mediating;Mediation;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentors;Methodology;mortality;multidisciplinary;Nature;novel;novel marker;novel therapeutics;observational cohort study;Operative Surgical Procedures;Organ;Outcome;Oxygen;Pathogenesis;Pathologic;Pathway Analysis;Pathway interactions;patient oriented research;Patients;peripheral blood;Peripheral Blood Mononuclear Cell;Pharmacologic Substance;Physicians;Physiological;Plasma;Play;Pneumonia;Population;post-transplant;prospective;protein biomarkers;Protein C;Proteins;Proteomics;PTPRC gene;Public Health;pulmonary function;Research;Research Personnel;Resistance;Respiratory Failure;RNA;Role;Sampling;Science;Sepsis;Severities;Severity of illness;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;Survivors;Syndrome;System;Techniques;Testing;therapeutic target;Thrombomodulin;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;Translational Research;translational scientist;Trauma;tumor immunology;Universities;Validation;vascular injury;Vasculitis;ventilation;von Willebrand Factor;Work

PROJECT_TITLE: Investigating the Role of Vascular Injury and Physiologic Dead Space in the Acute Respiratory Distress Syndrome


NIH_SPENDING_CATS: Behavioral and Social Science;Cannabinoid Research;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Services;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Substance Misuse;Substance Misuse Prevention;Telehealth

PHR: PROJECT NARRATIVE Youth involved in the legal system report elevate rates of cannabis use and are much more likely to develop cannabis use disorder than non-involved peers. The proposed K23 project aims to use Ecological Momentary Assessment to study cannabis use and Ecological Momentary Intervention to prevent cannabis use disorder for youth involved in the legal system. The proposed research will expand the investigator’s capacities as an independent health services researcher with expertise in: 1) cannabis use for youth involved in the legal system, 2) secondary prevention of cannabis use disorder, 3) Ecological Momentary Assessment and Intervention, 4) Personalized Feedback interventions, and 4) mobile health technology.

PI_NAMEs: HOLLOWAY, EVAN DAVID (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: acceptability and feasibility;Achievement;Address;Adolescent;Adult;aged;arm;attentional control;Behavior;behavior influence;behavioral health;Cannabis;cannabis use behavior;career;Clinical Trials Design;Complex;Data;Data Collection;digital health;Disease;Ecological momentary assessment;Education;efficacy testing;Eligibility Determination;Environment;experience;Family;family influence;Feedback;Focus Groups;follow-up;Foundations;Frequencies;Funding;Goals;Health;health care delivery;Health Services;Health Technology;Home;Hybrids;Impairment;Individual;individualized prevention;Intervention;Interview;juvenile justice system;K-Series Research Career Programs;Legal;Legal system;marijuana use;marijuana use disorder;Measures;meetings;Mentors;Methods;mHealth;mhealth interventions;Moods;novel;Outcome;Patient Self-Report;peer;peer influence;phrases;pilot test;polysubstance use;Population;prevent;Prevention;Prevention program;Primary Care;probation;Procedures;program costs;programs;prospective;psychoeducation;Randomized;reduced substance use;Reporting;Research;Research Design;Research Personnel;research study;Resources;Schools;screening;Secondary Prevention;service intervention;Services;social;substance use;substance use prevention;substance use treatment;System;Testing;theories;therapy design;Time;Touch sensation;Training;treatment arm;Triage;United States;usability;Work;Youth

PROJECT_TITLE: Ecological mHealth Cannabis Prevention for Youth Involved in the Juvenile Legal System


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Schizophrenia;Serious Mental Illness

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Schizophrenia is a chronic illness with no treatments that interfere with the disease process. To design treatments that will change the course of schizophrenia illness, we need to map the detailed ways in which brains of people with schizophrenia differ. In this project, a new imaging method will be used to test whether there is an abnormality in the number of specific types of connection points between neurons in the brains of people with schizophrenia.

PI_NAMEs: KALINOWSKI, AGNIESZKA  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Affect;Animal Model;Antibodies;Architecture;Array tomography;Automobile Driving;Autopsy;barrier to testing;Bioinformatics;Biological Models;Biology;Brain;brain tissue;Brodmann's area;career development;Caring;Chronic Disease;Clinical Research;Cognition;cohort;Complement component C4a;Computational algorithm;Copy Number Polymorphism;Coupling;Data;Dedications;density;Development;Disease;Equilibrium;Excitatory Synapse;experience;Follow-Up Studies;frontal lobe;Functional disorder;Future;Gene Expression;genome wide association study;Goals;Grant;high risk;hippocampal pyramidal neuron;histological image;imaging modality;Imaging Techniques;in vivo Model;Individual;Influentials;Inhibitory Synapse;K-Series Research Career Programs;Knowledge;Maps;Measures;Mediating;Mediator;Mental disorders;Mentors;Methodology;Modeling;Molecular;mouse model;multiplexed imaging;Neuroanatomy;neuroimaging;Neurons;neurotransmission;novel;Outcome Measure;Pathology;Persons;Physicians;postsynaptic;Prefrontal Cortex;presynaptic;primary outcome;Principal Component Analysis;Process;professor;Proteins;Publications;Research Personnel;Resolution;Sampling;Schizophrenia;Scientist;secondary outcome;Signal Transduction;Site;Specificity;Study models;Synapses;synaptic pruning;System;Testing;Therapeutic Intervention;therapeutic target;therapy design;Tissues;Training;transcriptome sequencing;transcriptomics;Universities;Up-Regulation;Work

PROJECT_TITLE: Synaptic protein composition and localization in individuals with schizophrenia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BN-P (57)]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cocaine;Complementary and Integrative Health;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Natural Products;Neurodegenerative;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: EL PASO

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS EL PASO

ORG_STATE: TX

PHR: Narrative Inflammation plays a pivotal role in the development of HIV-associated comorbidities, including HIV-associated neurocognitive disorders (HAND). The use of substances of abuse, such as cocaine, worsen the neurological outcomes in HIV patients. We propose to develop novel NLRP3 inhibitors that will minimize the neuroinflammation in HIV patients abusing cocaine.

PI_NAMEs: BUKRINSKY, MICHAEL ILYA;KULKARNI, AMOL ANANT (contact)

PROGRAM_OFFICER_NAME: ANANTHAN, SUBRAMANIAM

PROJECT_TERMS: Affect;analog;Animal Model;Anti-Inflammatory Agents;Anti-viral Therapy;antiretroviral therapy;Area;Astrocytes;ATP Hydrolysis;Binding;Biological;Blood - brain barrier anatomy;Brain;CASP1 gene;Cell Line;Cessation of life;Chemicals;Chronic;Clinical Research;Cocaine;Cocaine Abuse;cocaine exposure;cocaine use;Cognitive;comorbidity;computational chemistry;computer studies;Computer-Aided Design;Curcumin;cytokine;design;Development;disease model;drug candidate;Drug Design;drug discovery;druggable target;experimental study;Exploratory/Developmental Grant;Foundations;Functional disorder;Future;glial activation;Goals;HIV;HIV Envelope Protein gp120;HIV Infections;HIV-1;HIV-associated neurocognitive disorder;Human;humanized mouse;IL18 gene;Immunodeficient Mouse;Impaired cognition;improved;In Vitro;in vitro activity;in vivo;in vivo Model;Incidence;Individual;Infection;Inflammasome;Inflammation;Inflammatory;inhibitor;innovation;Interdisciplinary Study;Interleukin-1 beta;Investigation;Lead;Leucine-Rich Repeat;leucine-rich repeat protein;Leukocytes;Maintenance;marenostrin;Microglia;migration;Modeling;Molecular;monocyte;Motor;mouse model;Mus;natural product inspired;Natural Products;Nervous System Disorder;Neurocognitive;neuroinflammation;Neurologic;Neurological outcome;Neurons;neuropathology;novel;novel therapeutics;Nucleotides;pathogen;Pathogenesis;patient population;Patients;Pattern;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacophore;Play;Population;preclinical development;Preclinical Drug Development;Prevalence;prevent;Production;Property;Proteins;Publications;rational design;reconstitution;Reporting;Research;response;Resveratrol;RNA;Role;screening;Series;Signal Transduction;small molecule;Structure;Substance abuse problem;Substance of Abuse;substance use;Sulfonylurea Compounds;Testing;Therapeutic;Therapeutic Index;therapeutically effective;TNF gene;Toxic effect;Transgenic Mice;Virus Replication

PROJECT_TITLE: Development of NLRP3 inhibitors for HIV-associated neuroinflammation in cocaine use.

STUDY_SECTION_NAME: Special Emphasis Panel[ZDA1 JRB-N (O1)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services

PHR: PROJECT NARRATIVE As oncology capacity expands in sub-Saharan African countries such as Rwanda, implementation research is needed to improve the quality of patient-centered communication between clinicians and patients with cancer. The objective of this proposal is to develop patient-reported measures of communication quality that are appropriate for the Rwandan context and can be used to empower patients and clinicians to improve communication. Ultimately, a shift toward patient-centered care has the potential to improve cancer treatment outcomes, optimize resource utilization, mitigate clinician distress, and alleviate patient and family suffering. 1

PI_NAMEs: DEBOER, REBECCA  (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Active Learning;Address;Adherence;Advocate;Africa;African;Award;Belief;Bioethics;Budgets;Cancer Burden;cancer care;Cancer Center;cancer therapy;career;career development;Caring;Clinical;Cluster randomized trial;cognitive interview;Communication;Communication Research;cost;Country;Death Rate;Decision Making;Dedications;design;Distress;Educational Intervention;effective therapy;Emotional;empowerment;Equilibrium;Equity;Family;field study;Financial cost;Future;Goals;Healthcare;Healthcare Systems;Hospitals;implementation process;implementation research;implementation science;implementation strategy;improved;individual patient;Intervention;Intervention Trial;Interview;Malignant Neoplasms;Measures;Mentors;Modification;Morale;multidisciplinary;Oncology;oncology program;Outcome;Patient Care;patient oriented;Patient Outcomes Assessments;Patient-Centered Care;Patients;Personal Satisfaction;pilot trial;Positioning Attribute;Process;Program Evaluation;programs;Property;provider communication;Psychometrics;Quality of Care;Quality of life;randomized trial;Research;Research Personnel;Resources;response;Rwanda;Scientist;skills training;Structure;Surveys;Testing;Training;treatment adherence;treatment optimization;Treatment outcome;trial design;Validation;Validity and Reliability;Work

PROJECT_TITLE: Validation of Quality Measures for Patient-Centered Cancer Communication in Rwanda

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Attention Deficit Hyperactivity Disorder (ADHD);Autism;Behavioral and Social Science;Brain Disorders;Child Abuse and Neglect Research;Childhood Injury;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Mental Illness;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: Project Narrative/Public Health Relevance The proposed research will examine three biological pathways which may account for the association of maternal childhood abuse with offspring neurodevelopmental deficits: 1) endocrine dysfunction during pregnancy, 2) inflammation during pregnancy, and 3) genetic loading for neurodevelopmental disorders. Neurodevelomental deficits, including autism and attention deficit hyperactivity disorder (ADHD), are major causes of disability, morbidity, and unemployment across the life course. Ascertaining the mechanisms by which mother's abuse affects offspring neurodevelopment will have a profound impact on the design of public health interventions to protect the healthy development of children, specifically: 1) identify targets for potential prenatal and perinatal interventions, 2) improve screening in prenatal and pediatric care, and 3) identify children who will benefit from early intervention.

PI_NAMEs: ANDREA L. ROBERTS, ANDREA L. ROBERTS ANDREA L. ROBERTS (contact)

PROGRAM_OFFICER_NAME: GILBERT, LEAH KAYE

PROJECT_TERMS: Address;Adrenal Glands;Adult;Affect;Animals;Anxiety;Attention;Attention deficit hyperactivity disorder;autism spectrum disorder;Biological;Biological Assay;biological systems;Child;Child Abuse;Child Development;Child health care;Childhood;cost;Data;depressive symptoms;design;Diagnosis;disability;Disease;Disparity;disparity reduction;Documentation;Early Intervention;emotional abuse;Endocrine;Environmental Risk Factor;Exhibits;experience;Exposure to;Functional disorder;Generations;Genetic;Genetic Load;Genetic Risk;genetic risk factor;Genetic Variation;genome-wide;Genotype;Goals;Health;high risk;Homeostasis;Hormonal;Human;Hypothalamic structure;hypothalamic-pituitary-adrenal axis;immune function;improved;Inflammation;Inflammatory;Intervention;Life Cycle Stages;life span;Maternal Exposure;Maternal-Fetal Transmission;Measures;Mediating;Mental Depression;Mental disorders;Mental Health;Morbidity - disease rate;Mothers;neurodevelopment;Neurodevelopmental Deficit;Neurodevelopmental Disorder;neuropsychiatric disorder;neuropsychiatry;Nurses' Health Study;offspring;Outcome;Pathway interactions;perinatal intervention;physical abuse;physical conditioning;Pituitary Gland;pituitary thyroid axis;polygenic risk score;Population;Pregnancy;Pregnant Women;prenatal;Prenatal care;prevent;Prevention;Prospective cohort;public health intervention;public health priorities;public health relevance;Recording of previous events;Research;Risk;Sampling;screening;Sexual abuse;Shapes;Social Behavior;Social Problems;Stressful Event;stressor;System;systemic inflammatory response;Testing;Thyroid Gland;Time;Unemployment;Woman

PROJECT_TITLE: Maternal Exposure to Childhood Abuse and Disparities in Offspring Neurodevelopment: Identifying Mechanisms

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]