NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Immunization;Immunotherapy;Neurodegenerative;Neurosciences;Prevention;Vaccine Related

ORG_CITY: HUNTINGTON BEACH

ORG_NAME: INSTITUTE FOR MOLECULAR MEDICINE

PHR: Project Narrative The first-in-human DNA vaccine, AV-1959D based on MultiTEP platform is designed (i) to augment anti-Aβ antibody production without activation of potentially harmful autoreactive Th cells (ii) to activate Th cells specific to foreign epitopes incorporated in MultiTEP, providing broad coverage of the targeted population with high MHC class II gene polymorphism and (iii) to activate naïve and memory Th cells overcoming the immunosenescence in the older people. Of note, due to an ethical imperative raised by the FDA during our pre-IND meeting, we propose Phase 1 safety/tolerability/immunogenicity trials of AV-1959D in early stage AD patients based on IND18953 cleared by the FDA in April 2020 prior to initiating the preventive trials in asymptomatic people at risk of MCI/AD.

PI_NAMEs: AGADJANYAN, MICHAEL G (contact);SCHNEIDER, LON S;SULTZER, DAVID

PROGRAM_OFFICER_NAME: CLARKE, AKANNI YAO

PROJECT_TERMS: abeta oligomer;active method;Aducanumab;Adverse event;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Amyloid;Amyloid beta-Protein;AN-1792;Antibodies;Antibody Formation;Antibody titer measurement;Attenuated;autoreactivity;B-Lymphocyte Epitopes;B-Lymphocytes;Binding;Biological Markers;Blood;Brain;Clinical;Clinical Data;Clinical Trials;cognitive function;Collecting Cell;Control Groups;cost;cost effective;Data;design;Detection;Disease;DNA Vaccines;Dose;Double-Blind Method;Early Intervention;enzyme linked immunospot assay;Enzyme-Linked Immunosorbent Assay;Epitopes;Ethics;first-in-human;follow-up;Future;Genetic Polymorphism;Goals;Helper-Inducer T-Lymphocyte;Hepatitis B;Human;human monoclonal antibodies;Immune response;Immunize;immunogenic;immunogenicity;immunosenescence;Immunotherapeutic agent;Immunotherapy;Impaired cognition;Inflammation;Influenza;Injections;Interferon Type II;intravenous injection;Laboratories;manufacture;Measures;Memory;Methods;MHC Class II Genes;Monkeys;Monoclonal Antibodies;mouse model;multidisciplinary;non-demented;novel marker;Nucleic Acids;older patient;Older Population;Oryctolagus cuniculus;PADRE 45;Participant;Passive Immunization;Passive Immunotherapy;Pathologic;Pathologic Processes;Pathology;patient population;Patients;peptide B;Peptides;peripheral blood;Peripheral Blood Mononuclear Cell;Persons;Phase;phase 1 study;phase I trial;Physical Examination;Placebo Control;Placebos;Populations at Risk;Positron-Emission Tomography;pre-Investigational New Drug meeting;Preparation;prevent;Preventive;Preventive measure;Preventive treatment;Preventive vaccine;primary outcome;programs;prophylactic;Publishing;Randomized;Recommendation;Reporting;response;retinal S antigen peptide M;Risk;Safety;safety testing;secondary outcome;Self Tolerance;Senile Plaques;Serum;synthetic peptide;Target Populations;tau aggregation;tau Proteins;Test Result;Testing;Tetanus Toxin;Therapeutic;Time;treatment arm;U-Series Cooperative Agreements;Vaccinated;Vaccination;Vaccine Clinical Trial;vaccine evaluation;vaccine strategy;vaccine trial;Vaccinee;Vaccines

PROJECT_TITLE: Safety/Tolerability/Immunogenicity of first-in-human Aβ DNA vaccine, AV-1959D Phase 1 trials in early-stage AD subjects: based on IND18953 cleared by FDA.


ADMINISTERING_IC: EB

ARRA_FUNDED: N

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Colorectal Cancer;Digestive Diseases;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_FIPS: US

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: This study will advance and optimize a co-registered photoacoustic microscopy and ultrasound endoscopic system to fill a critical gap in the current management of rectal cancer: identifying tumor treatment response after neoadjuvant therapy. A clinical trial will evaluate the system’s ability to identify treatment responders and therefore reduce morbidity in the treatment of this common disease. Finally, serial surveillance of patients with complete responses to therapy will investigate markers of tumor recurrence among this high risk population.

PI_NAMEs: CHAPMAN, WILLIAM ;ZHU, QUING  (contact)

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: absorption;Acoustics;Adopted;Adoption;Aftercare;Age;Architecture;Beds;Blood;Blood Vessels;cancer cell;cancer diagnosis;Cancer Etiology;Cancer Patient;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Cicatrix;Clinical;Clinical Trials;cohort;Colorectal Cancer;Colorectal Neoplasms;common treatment;Computer software;Contrast Media;convolutional neural network;Coupled;Custom;deep neural network;Development;Diagnosis;Diagnostic;Disease;Drug or chemical Tissue Distribution;Edema;Eligibility Determination;Endoscopic Ultrasonography;Endoscopy;Excision;Goals;Health Care Costs;Hemoglobin;high risk population;Human;Hybrids;Image;Imaging Device;imaging modality;imaging probe;imaging system;Imaging Techniques;Imaging technology;improved;In complete remission;Incidence;Individual;Institution;Intestines;Lasers;Magnetic Resonance Imaging;Mainstreaming;Malignant Neoplasms;men;Methods;microscopic imaging;Microscopy;Modality;Modeling;Monitor;Morbidity - disease rate;Mucous Membrane;Neoadjuvant Therapy;neural;neural network;neural network classifier;novel;Operative Surgical Procedures;Optics;Outcome;Oxygen;Pathologic;Pathology;Patients;Pattern;Pattern Recognition;Performance;photoacoustic imaging;Physiologic pulse;prospective;Protocols documentation;prototype;Quality of life;Radiation;Radiation therapy;radiological imaging;Reaction;Recommendation;Recovery;Rectal Cancer;Rectal Neoplasms;Rectum;Recurrent tumor;Reporting;Research;research clinical testing;Residual Cancers;Residual Neoplasm;Residual state;Resolution;response;Risk;Risk Management;second harmonic;Sensitivity and Specificity;standard of care;Surgeon;surveillance imaging;System;Techniques;Technology;technology validation;tertiary care;Testing;Texture;Time;tissue mapping;Tissues;treatment responders;treatment response;tumor;Tumor Biology;Tumor Markers;Tumor Tissue;Ultrasonography;ultrasound;United States;Unnecessary Surgery;Validation;Woman

PROJECT_TITLE: Predicting neoadjuvant treatment response of locally advanced rectal cancer using co-registered endo-rectal photoacoustic and ultrasound imaging

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AR

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Childhood Injury;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Transplantation;Unintentional Childhood Injury

ORG_CITY: BOSTON

ORG_DEPT: DENTISTRY

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: Narrative The periosteum is a highly specialized tissue microenvironment. Periosteal cells regulate the strength of bones by controlling bone width and the ability of bones to heal after fracture. This grant focuses on the importance of BMP2 signaling in regulating periosteal cell function during growth in width and during fracture healing.

PI_NAMEs: ROSEN, VICKI  (contact)

PROGRAM_OFFICER_NAME: CHEN, FAYE H

PROJECT_TERMS: Address;Affect;Aging;Anabolic Agents;Antibodies;Area;Biological Process;BMP2 gene;bone;bone fracture repair;Bone Growth;Bone Matrix;bone repair;bone strength;Bone Surface;Bone Transplantation;Cell Physiology;Cell Survival;Collagen;cortical bone;Data;Defect;Deposition;Development;disability;Engineering;Ensure;Excision;Exhibits;experimental study;Extracellular Matrix;Failure;Fracture;fracture risk;Genes;Genetic Recombination;Grant;Growth;healing;Homeostasis;Impairment;Injury;interest;Knowledge;Length;Life;Location;long bone;Maps;Mediator;Modeling;Molecular;Monitor;mouse model;Mus;neutralizing antibody;Newborn Infant;novel;novel therapeutics;Operative Surgical Procedures;Osteogenesis;osteogenic;osteoporosis with pathological fracture;Outcome;Pathological fracture;Pathway interactions;Patients;Pattern;Periosteal Cell;Periosteum;Physiological;Physiology;Population;postnatal;prevent;Procedures;Production;progenitor;Publishing;Regenerative capacity;Regulation;repaired;Reporter;response;Risk Reduction;Role;self-renewal;Signal Pathway;Signal Transduction;skeletal;skeletal stem cell;Skeleton;Source;spatiotemporal;stem cell niche;stem cells;targeted agent;Testing;Therapeutic;Time;Tissues;transcriptome;transcriptome sequencing;Trauma;tumor;Visit;Weight-Bearing state;Width;WNT Signaling Pathway;Work

PROJECT_TITLE: BMP2 Regulation of Periosteal Function

STUDY_SECTION: SBDD

STUDY_SECTION_NAME: Skeletal Biology Development and Disease Study Section[SBDD]


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Aging;Arthritis;Autoimmune Disease;Bioengineering;Biotechnology;Chronic Pain;Gene Therapy;Genetics;Immunotherapy;Pain Research;Regenerative Medicine;Rheumatoid Arthritis;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_DEPT: ORTHOPEDICS

PHR: Project Narrative The goals of this project are to combine synthetic biology and tissue engineering to create therapeutic cells that can produce biologic drugs on demand. These cells will be implanted in vivo to determine their ability to treat rheumatoid arthritis by providing long-term, feedback control of different biologic drugs.

PI_NAMEs: GUILAK, FARSHID  (contact);PHAM, CHRISTINE T.

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Acute;Adult;Adverse effects;Adverse event;Amplifiers;anakinra;Anti-Cytokine Therapy;Anti-Inflammatory Agents;Arthritis;arthritis therapy;Autoimmune Diseases;behavior test;Biological;Biological Products;Biological Response Modifier Therapy;biomaterial compatibility;bone erosion;cancer type;Cell Physiology;Cell Therapy;Cells;Chemical Dynamics;Chronic;Chronic Disease;chronic inflammatory disease;Clinical;clinical translation;collagen antibody induced arthritis;Collagen Arthritis;Complex;CRISPR/Cas technology;Cues;Custom;cytokine;design;Development;disability;Disabling;Disease;Dose;Drug Delivery Systems;drug production;efficacy testing;Encapsulated;engineered stem cells;Engineering;Environment;Exhibits;Feedback;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genome engineering;Goals;Histologic;IL6ST gene;Implant;implantation;In Vitro;in vivo;in vivo evaluation;Induction of Apoptosis;Infection;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;Injections;innovation;Interleukin-1;Interleukin-6;joint destruction;K/BxN model;Methods;Modeling;Molecular;mouse model;Mus;Musculoskeletal;next generation;Output;Pain;Pain Measurement;Patients;personalized medicine;Pharmaceutical Preparations;Predisposition;Prevalence;prevent;Process;Production;programs;receptor;Regenerative Medicine;response;Rheumatoid Arthritis;Risk;Safety;safety engineering;scaffold;Sensitivity and Specificity;Sepharose;Serum;Severities;stem cell based approach;stem cell biology;stem cells;subcutaneous;success;Suicide;Swelling;synthetic biology;Synthetic Genes;System;systemic inflammatory response;Testing;Therapeutic;Time;Tissue Engineering;Tissues;TNF gene;TNFRSF1A gene;Translations;Treatment Efficacy;Work

PROJECT_TITLE: Genetically-engineered stem cells for self-regulating arthritis therapy

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: It is unknown why some cancer cells within a given tumor cell population die while others do not when the whole population is exposed to a death stimulus like an anti-cancer drug. In this project, we test the hypothesis that these differences are due to cell-to-cell variation in the cellular recycling process, autophagy. Understanding these mechanisms may allow new approaches to control how we kill cancer cells and to reduce heterogeneity in tumor cells responses to therapy and thus provide a new way to improve cancer treatment.

PI_NAMEs: DEGREGORI, JAMES V (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;Apoptotic;Autophagocytosis;BBC3 gene;BCL2L11 gene;BH3 Domain;Binding Sites;cancer cell;cancer therapy;Cell Death;Cell Membrane Permeability;cell type;Cells;Cessation of life;Clinical;Clinical Trials;Complex;Cytotoxic agent;Decision Making;Dose;Drug resistance;Drug Stability;Evolution;Exposure to;FOXO3A gene;Funding;Future;Genes;Genetic;Grant;Heterogeneity;Human Genome;improved;inhibitor;insight;intervention effect;Introns;Malignant Neoplasms;Methods;Molecular;Mutation;Necrosis;neoplastic cell;novel;novel strategies;optogenetics;outcome prediction;Outer Mitochondrial Membrane;Pathway interactions;Pharmaceutical Preparations;Pharmacology;Phosphotransferases;Population;Process;Proteins;Recycling;Regulation;Reporting;Resistance;response;RIPK3 gene;scaffold;side effect;Signal Transduction;Stimulus;Techniques;Tertiary Protein Structure;Testing;therapy resistant;TP53 gene;transcription factor;treatment response;tumor heterogeneity;Variant;Work

PROJECT_TITLE: Autophagy regulation of apoptosis and necroptosis within cell populations

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


NIH_SPENDING_CATS: Aging;Arthritis;Atherosclerosis;Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Rheumatoid Arthritis

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Rheumatoid arthritis (RA) affects nearly 1.5 million people in the US and we need new treatments for it and the increased risk of atherosclerosis that accompanies it. Isolevuglandins (isoLGs) are reactive products of oxidative stress that change proteins causing inflammation and worsening autoimmune disease and atherosclerosis in animal models. We will study 2-hydroxybenzylamine (2-HOBA), a compound that scavenges isoLGs and has the potential to both treat RA and decrease atherosclerosis, to determine its safety and potential efficacy in patients with RA.

PI_NAMEs: ORMSETH, MICHELLE JANE (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: adduct;Adverse event;Affect;aggressive therapy;Amines;Animal Model;Animals;anti-dsDNA antibodies;Antioxidants;Aorta;arm;arthritis therapy;Atherosclerosis;atherosclerosis risk;Autoantibodies;Autoimmune Diseases;Autoimmunity;Binding;Blood Pressure;Buckwheat;C-reactive protein;Cardiovascular Diseases;cardiovascular risk factor;Cell Physiology;Cells;Clinical Research;Clinical Trials;comorbidity;covalent bond;Dendritic Cells;design;Disease;Disease remission;DNA;Dose;Double-Blind Method;Dropout;Drug Kinetics;effective therapy;efficacy evaluation;Erythrocyte Sedimentation Rate;Excess Mortality;Future;healthy volunteer;Hour;Human;Hypertension;immunogenic;improved;In Vitro;Infiltration;Inflammation;Inflammatory;inflammatory marker;Injury to Kidney;joint inflammation;Joints;Lipid Peroxidation;lipid solubility;Malondialdehyde;Measures;Molecular Conformation;Monitor;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;Outcome;Oxidative Stress;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phase;phase 2 study;Phase II Clinical Trials;pill;Pilot Projects;Placebos;Plasma;Population;prevent;Prevention;Production;Property;Proteins;Pyridoxamine;Randomized;Reaction;Reactive Oxygen Species;Rheumatoid Arthritis;Safety;secondary outcome;Signal Transduction;Structure;Systemic Lupus Erythematosus;T-Cell Proliferation;T-Lymphocyte;Therapeutic;Tissues;treatment adherence;treatment group;Visit;Vitamin E;Work

PROJECT_TITLE: 2-HOBA Phase 2 Clinical Trial in Rheumatoid Arthritis

STUDY_SECTION: AMSC

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Clinical Trials Study Section [AMSC]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_CITY: NOTRE DAME

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: PROJECT NARRATIVE The majority of patients with metastatic breast cancer do not respond to immunotherapy with the tumor- infiltrating neutrophils as a major factor to mediate the immunotherapy resistance. Our preliminary results identify the metabolic enzyme aconitate decarboxylase (ACOD1) to be dramatically upregulated and functionally critical in tumor-infiltrating neutrophils. Upon completion of our project, we expect to define the mechanisms underlying neutrophil ACOD1 function in breast cancer metastasis and demonstrate the potential of ACOD1 inhibition to enhance metastatic breast cancer response to immunotherapy.

PI_NAMEs: LU, XIN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Ablation;Acceleration;Aconitic Acid;Address;Anti-Inflammatory Agents;Antibodies;Antioxidants;B-Lymphocytes;bench-to-bedside translation;Biological Assay;bone;breast cancer metastasis;Breast Cancer Model;Breast Cancer Treatment;cancer immunotherapy;Carboxy-Lyases;Cell model;Cells;chemotherapy;Clinical;curative treatments;Cytotoxic T-Lymphocytes;deprivation;Development;Ensure;Enzymes;experimental study;Face;follow-up;Gene Silencing;Genes;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Human;Immune;immune checkpoint blockade;Immune Evasion;immune resistance;Immunofluorescence Immunologic;immunoregulation;Immunosuppression;Immunotherapeutic agent;Immunotherapy;improved;In Vitro;Infiltration;inhibitor;Injections;JAK2 gene;Knockout Mice;Knowledge;Link;loss of function;Lung;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metabolic;Metastatic breast cancer;Metastatic Neoplasm to the Lung;Mitochondria;Modeling;Molecular;Morbidity - disease rate;mortality;Mouse Mammary Tumor Virus;mouse model;Mus;Myeloid-derived suppressor cells;Neoplasm Metastasis;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;Outcome;Pathway interactions;Patients;pharmacologic;Phenotype;polyoma middle tumor antigen;Population;pre-clinical;Production;Prognosis;programmed cell death ligand 1;programs;Research;Resistance;response;Role;Safety;Sampling;single cell technology;single-cell RNA sequencing;Stains;STAT3 gene;synergism;T cell infiltration;T-Lymphocyte;Techniques;Testing;Therapeutic;therapeutic target;Tissue Microarray;Transgenic Mice;triple-negative invasive breast carcinoma;tumor;Tumor Immunity;tumor microenvironment;Up-Regulation;Validation;validation studies;Wild Type Mouse

PROJECT_TITLE: Immunosuppression and Metabolic Rewiring in Tumor-infiltrating Neutrophils

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ROCHESTER

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative: Within the eukaryotic cell nucleus, the human genome is associated with core histones and other proteins to form a multifaceted complex known as chromatin. This complex brings about the orderly packaging of the immense length of DNA within the tiny volume of the nucleus and is directly involved in critical cell functions. This project aims to elucidate fundamental aspects of chromatin structure, and how chromatin modifiers regulate access to DNA within chromatin and contribute to control of gene expression.

PI_NAMEs: HAYES, JEFFREY J (contact)

PROGRAM_OFFICER_NAME: CHOW, CHI-WING

PROJECT_TERMS: Acetylation;Affect;Architecture;Binding;Biochemical;Biological Models;biophysical techniques;Cell Nucleus;Cell Physiology;Chromatin;Chromatin Modeling;Chromatin Remodeling Factor;Chromatin Structure;Chromosomes;Communication;Complex;Disease;DNA;DNA Repair;Elements;Epigenetic Process;Eukaryotic Cell;Gene Expression;Genes;Genetic Diseases;Genetic Transcription;Genome;Genomic DNA;Goals;Histones;HMGN Proteins;Human Chromosomes;Human Genome;Knowledge;Length;Mediating;Modification;Molecular;Mutation;Nature;Nucleosomes;Physical condensation;Post-Translational Protein Processing;Process;Proteins;Regulation;Structure;System;Tail;Work

PROJECT_TITLE: Molecular mechanisms of the core and linker histone tail domains that drive chromatin condensation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-MGG-C(55)R]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Liver Disease;Pancreatic Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: NARRATIVE Pancreatic cancer patients have a high incidence of liver metastasis for which there are no effective treatments. Our recent work has shown that the splicing regulator RBFOX2 plays an important role in pancreatic cancer progression. Here, we propose to utilize state-of-the-art mouse models and ex vivo platforms to modulate splicing of key RBFOX2 splicing targets, gaining novel biological insights that can be harnessed to prevent or reduce PDAC liver metastases.

PI_NAMEs: MANN, KAREN M (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Alternative Splicing;Antisense Oligonucleotides;Automobile Driving;Biological;Biological Process;cancer cell differentiation;Cancer Center;Cancer Control;cancer initiation;cancer recurrence;cancer stem cell;Cell Differentiation process;cell growth;Cell Line;cell motility;Cells;cohort;Complementary DNA;Coupled;crosslinking and immunoprecipitation sequencing;Data;defined contribution;Diagnosis;Differentiation Antigens;Disease;Disease Outcome;Disease Progression;Disseminated Malignant Neoplasm;Down-Regulation;effective therapy;embryonic stem cell;Event;Evolution;Excision;Exclusion;Exhibits;exon skipping;Exons;Flow Cytometry;Genetic Screening;genome-wide;Growth;Human;human embryonic stem cell;Immunoprecipitation;improved;in vivo;Incidence;induced pluripotent stem cell;insight;Intervention;Invaded;KRAS2 gene;Link;Liquid Chromatography;Malignant neoplasm of pancreas;Malignant Neoplasms;Mediating;Metastatic Neoplasm to the Liver;Modeling;Modification;Molecular;Motility;mouse model;Neoplasm Metastasis;novel;Nuclear;Oncogenic;Outcome;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic neoplasm;Pathogenicity;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;Phosphorylation Inhibition;Phosphorylation Site;Play;prevent;Process;programs;Progression-Free Survivals;Protein Isoforms;Proteins;Proteomics;Recurrence;Recurrent disease;Regulation;Relapse;rho;RNA Splicing;RNA-Binding Proteins;Role;Serine;single-cell RNA sequencing;spheroids;stem cell differentiation;stem cell population;stem cells;stemness;tandem mass spectrometry;Testing;Threonine;Tissue Microarray;Transcript;transcriptome sequencing;tumor;tumor growth;tumor progression;Tumor Suppressor Proteins;Tyrosine Phosphorylation;Work

PROJECT_TITLE: RBFOX2 deregulation promotes pancreatic cancer progression through alternative splicing

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Genetics;Neurodegenerative

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Many events during animal development require that proteins are made at particular cellular locations where they are needed; often cells accomplish this by moving messenger RNAs (mRNAs) that code for proteins to the locations where they are needed and applying controls to ensure that protein is produced only there and only at the right time. Impairment of such mechanisms is associated with cancer metastasis, neurodegenerative disorders, and infertility. The proposed studies use sophisticated microscopy methods, innovative biochemical strategies, and genomic approaches to investigate how gathering mRNAs together in structures called germ granules localizes them within an embryo to control the production of proteins needed for cells to follow the right developmental programs.

PI_NAMEs: GAVIS, ELIZABETH R (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Animals;Behavior;Binding;Biochemical;Biological;Body Patterning;Cells;Client;Code;cohort;Complex;Cytoplasmic Granules;Defect;Development;Disease;Drosophila genus;egg;Embryo;Embryonic Development;Event;Foundations;Genes;Genetic;Genomic approach;Germ;Germ Lines;Goals;high resolution imaging;Impairment;Infertility;innovation;insight;Lead;Location;Maintenance;Malignant Neoplasms;Maternal Messenger RNA;Messenger RNA;Methods;Microscopy;Modeling;Neoplasm Metastasis;Nerve Degeneration;Neurodegenerative Disorders;novel;Oocytes;Phase Transition;Play;posttranscriptional;Prevalence;Production;programs;Proliferating;protein distribution;Proteins;recruit;Regulation;Research;Ribonucleoproteins;RNA;RNA metabolism;Role;self organization;Structure;Structure of primordial sex cell;Time;Transcript;Translations;Work

PROJECT_TITLE: Mechanisms of mRNA localization and translational control in Drosophila development

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Patient Safety

ORG_CITY: NEW YORK

ORG_NAME: VISITING NURSE SERVICE OF NEW YORK

PHR: PROJECT NARRATIVE Community-living older adults with Alzheimer’s Disease and Related Dementias (ADRD) make up 31% of the Medicare Home Health (HH) patient population and receive more intensive HH care, yet remain at higher risk for adverse outcomes including readmission. Efforts to improve HH care quality for those with ADRD must consider the critical contributions of family caregivers: family caregivers are a major source of support during HH and prior work indicates that engaging/supporting caregivers in care delivery improves outcomes for older adults. The proposed research will elucidate the role and support needs of ADRD caregivers during HH and determine how family caregiver availability and capacity affect HH outcomes for patients with ADRD, providing crucial foundational evidence for the development of effective interventions to improve HH care quality for those with ADRD by better supporting their family caregivers.

PI_NAMEs: BURGDORF, JULIA  (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adverse event;adverse outcome;Advocacy;Affect;Aging;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulatory Care;beneficiary;care delivery;care outcomes;career;caregiver education;Caregiver support;Caregivers;caregiving;Caring;Characteristics;Communities;community living;Complex;Data;Data Sources;Dementia;Dementia caregivers;dementia caregiving;Development;Discipline;Discipline of Nursing;effective intervention;Equipment;experience;Family;Family Caregiver;Family Study;family support;Functional impairment;functional improvement;Funding;Future;Goals;Health;health care delivery;health care quality;health plan;Healthcare;high risk;Home;Home Care Services;hospital readmission;Hospitalization;Household;human old age (65+);Impaired cognition;improved;improved outcome;Individual;Institution;Institutionalization;Intensive Care;Interdisciplinary Study;interest;Intervention;Knowledge;Length of Stay;Link;Logistic Regressions;Measures;Medical;Medicare;Medicare claim;medication administration;meetings;Modeling;Needs Assessment;novel;Nurses;nursing skill;Occupational Therapy;older adult;Outcome;Outcome Measure;Ownership;Patient Care;patient population;Patient-Focused Outcomes;Patients;payment;Persons;Physical therapy;Procedures;readmission rates;readmission risk;Reporting;Research;Research Personnel;Resources;Role;Sample Size;Sampling;satisfaction;Self Care;Services;Severities;Site;skills;Source;Standardization;Structure;Supervision;tool;Training;trend;United States Centers for Medicare and Medicaid Services;Visit;willingness;Work

PROJECT_TITLE: Effects of Family Caregiver Availability and Capacity on Home Health Care for Older Adults with Alzheimer's Disease and Related Dementias

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Coronaviruses;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Health Services;Infectious Diseases;Mental Health;Physical Rehabilitation;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Rehabilitation

ORG_CITY: PHILADELPHIA

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative It is unlikely that COVID-19 vaccines will lead to the end of PASC syndrome given the emergence of increasingly infectious variants and the high numbers of individuals with continued symptoms several months from their initial infection. High rates of hesitancy and refusal to become vaccinated, both in the US and worldwide, will also contribute to the persistence of both COVID-19 and PASC. Given that there has been over 79 million people infected with the SARS-CoV-2 virus in the U.S. and 434 million worldwide, it is imperative to develop and rigorously test the effectiveness and cost-effectiveness of a rehabilitation program that may ameliorate symptoms and restore pre-infection function.

PI_NAMEs: DILLINGHAM, TIMOTHY R (contact)

PROGRAM_OFFICER_NAME: MARDEN, SUSAN F

PROJECT_TERMS: 2019-nCoV;acute infection;acute symptom;Address;Advisory Committees;Aerobic;Anxiety;Breathing;Caring;Clinic;Clinical;Cognition;cognitive function;Cognitive remediation;conditioning;Consensus;Contracts;cost;cost comparison;cost effective;cost effectiveness;cost estimate;COVID-19;COVID-19 severity;COVID-19 survivors;COVID-19 vaccine;Data;Diagnosis;Diffusion;Disease;Educational Materials;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness testing;Enrollment;evidence base;experience;Fatigue;flexibility;functional improvement;functional restoration;group intervention;Growth;Guidelines;Health;Health system;improved;improved outcome;Incidence;Individual;Infection;Inpatients;Intervention;intervention cost;intervention effect;long-term sequelae;Longitudinal Surveys;Measures;Mental Depression;multidisciplinary;multimodality;Muscle;Neuropsychology;Outcome;Outpatients;Pain;Patient Education;patient oriented;Patients;persistent symptom;Persons;pilot trial;Policies;Policy Developments;Population;Post-Acute Sequelae of SARS-CoV-2 Infection;post-COVID-19;prevent;primary outcome;Program Development;programs;Psyche structure;psychologic;Randomized;Randomized, Controlled Trials;Recommendation;Recovery;reduce symptoms;Rehabilitation therapy;rehabilitative care;Reporting;Research;Resistance;Respiratory Diaphragm;Sampling;SARS-CoV-2 infection;SARS-CoV-2 negative;SARS-CoV-2 positive;secondary outcome;Self Management;severe COVID-19;Severities;Social Functioning;Standardization;Stress;Stretching;Surveys;Survivors;symptom management;Symptoms;Syndrome;System;Testing;Time;Titrations;treatment as usual;trial design;Vaccinated;Vaccines;Variant;vestibular system;Virus;walking speed;Work

PROJECT_TITLE: Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program to Improve the Functioning of Persons Suffering from Post-acute Sequelae of SARS-CoV-2 infection (PASC): A Randomized Controlled

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: SALT LAKE CITY

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Comparing the US to 184 other nations, only 40 nations have higher rates of low birth weight (LBW) (less than 5 pounds, 8 ounces) and 53 have higher rates of preterm birth (PTB) (before 37 weeks). The surprisingly high incidence of LBW and PTB is driven primarily by birth outcomes among low-income, disproportionately Black, mothers, pointing to social and economic determinants of health. This study uses the Panel Study of Income Dynamics, a nationally representative, longitudinal dataset to: (1) compare the effects on birth outcomes of individual ESPs and ESP combinations; (2) determine the extent to which improvements to healthcare access, food insecurity, psychological distress, and prenatal health behaviors mediate the relationship between ESP generosity and birth outcomes; and (3) identify whether ESP generosity effects are moderated by poverty level, race, marital status, and/or education. By improving scientific knowledge of which ESPs or ESP packages work best in general, for specific health risk-factors, and for specific groups, this research will support the funding, design, and delivery of policies and interventions that promote economic security and reduce rates of, and inequalities in, LBW and PTB.

PI_NAMEs: REYNOLDS, MEGAN  (contact)

PROGRAM_OFFICER_NAME: CHINN, JUANITA JEANNE

PROJECT_TERMS: Address;adverse birth outcomes;Affect;Birth;Black race;COVID-19 pandemic;Data;design;Diet;disadvantaged women;Disparity;Disparity population;economic determinant;Economics;Education;Failure;Fetal health;food insecurity;Funding;Goals;graduate school;Health;Health behavior;health care availability;health determinants;Health Promotion;Household;improved;improved outcome;Incidence;Income Tax;Individual;Inequality;innovation;Intervention;Knowledge;Link;Living Costs;Living Standards;longitudinal dataset;Low Birth Weight Infant;Low income;Low Income Population;lower income families;Marital Status;Marketing;Maternal and Child Health;Measures;Mediating;Mediator;Mothers;novel;nutrition;Outcome;Outcomes Research;panel study of income dynamics;Play;Policies;Policy Maker;population health;Poverty;Pregnant Women;Premature Birth;prenatal health;prevent;programs;psychological distress;Quasi-experiment;Race;Reduce health disparities;Research;Rewards;Risk;Risk Estimate;Risk Factors;Role;safety net;Security;social;social determinants;Social Policies;Social status;socioeconomic disadvantage;socioeconomics;Stress;Subgroup;unemployment insurance;United States;United States National Institutes of Health;Unmarried;Variant;Wages;Woman;Work

PROJECT_TITLE: Economic security policy and birth outcomes among socio-economically disadvantaged women

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


ORG_CITY: ATLANTA

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it investigates the biological basis underlying the migration of neural crest cells. Neural crest cell migration represents directed cell migration and is critical to diverse diseases including craniofacial anomalies, heart defects, and cancer. Mechanistic understanding of the complex dynamic events during in vivo cell migration will shed light on the etiology of these diseases.

PI_NAMEs: NIE, SHUYI  (contact)

PROJECT_TERMS: Actins;Affect;Biological;cdc42 GTP-Binding Protein;cell behavior;Cell Culture Techniques;Cell membrane;Cell Migration Inhibition function;Cell model;cell motility;Cell Physiology;Cell Polarity;Cells;Collaborations;Complex;Computer Models;Computer Simulation;Congenital Abnormality;Craniofacial Abnormalities;Cytoplasm;Cytoskeletal Modeling;Cytoskeleton;Data;Defect;Development;Disease;Embryonic Development;Equilibrium;Etiology;Event;Experimental Designs;experimental study;Family;Feedback;Filament;Filopodia;Goals;Guanosine Triphosphate Phosphohydrolases;heart defect;Homeostasis;Human;human disease;Imaging technology;improved;in silico;in vivo;Knowledge;Lead;Malignant Neoplasms;Mediating;Membrane;Microfilaments;migration;Modeling;models and simulation;Molecular;Morphogenesis;Neural Crest;Neural Crest Cell;neurodevelopment;novel;polarized cell;polymerization;Polymers;Process;Proteins;Public Health;recruit;Regulation;Research;rho;Role;scaffold;Signal Transduction;Stress Fibers;System;Testing;Tissues;Work;Xenopus

PROJECT_TITLE: Coordinated Actin Regulation in Directed Neural Crest Cell Migration

STUDY_SECTION_NAME: Development - 2 Study Section[DEV2]


NIH_SPENDING_CATS: Bioengineering;Biotechnology

ORG_CITY: Newark

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: Project Narrative The goal of this proposal will be to continue to develop a diverse set of new chemical tools centered on tetrazine ligation– the fastest known bioorthogonal reaction. The work will advance new biotechnological, biomedical and pharmaceutical applications through new chemical tools for labeling biomolecules in the intracellular environment, new methods for selectively tagging and assembling proteins, and new technology for probing biological targets in living systems with spatiotemporal control.

PI_NAMEs: FOX, JOSEPH M (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TITLE: Toolkit for Fast, Multipurpose and Inducible Bioorthogonal Chemistry

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence;Precision Medicine

PHR: PROJECT NARRATIVE Despite the explosion of biological knowledge that has occurred since the turn of the century, the impact on drug discovery and precision medicine has been modest. To address the key issues limiting this success, this project will develop an AI-driven, integrated protein structure and interaction network-based approach, MEDICASCY-X, that will predict disease associated proteins, identify the most effective protein targets to treat the disease and suggest effective, de-risked therapeutic strategies. MEDICASCY-X will be applied to improve drug discovery and precision medicine and will be validated by developing novel preclinical treatments for a variety of intractable diseases.

PI_NAMEs: SKOLNICK, JEFFREY  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Algorithms;Antibodies;Artificial Intelligence;Binding;Biochemical;Biological;Chemical Structure;Chemistry;Clinical Trials;comorbidity;Complex;cost;cryptic protein;deep learning;Diagnostic;Disease;disease model;drug candidate;drug discovery;Drug Interactions;Drug Targeting;Effectiveness;Epigenetic Process;exome;Explosion;Free Energy;gain of function;Genetic;Geometry;Human;Immunotherapy;improved;Individual;insight;Knowledge;Ligands;Modeling;Molecular;Network-based;novel;Pharmaceutical Preparations;Pharmacotherapy;Phylogenetic Analysis;pre-clinical;precision medicine;protein complex;Protein Family;protein structure;Proteins;Risk;Safety;screening;side effect;small molecule;Specificity;Structure;success;Therapeutic;Time;tool;Trees;virtual;Work

PROJECT_TITLE: Interplay of inherent promiscuity and specificity in protein biochemical function with applications to drug discovery and exome analysis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Emphysema;HIV/AIDS;Infectious Diseases;Lung

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE COPD is an HIV-associated lung disease and a leading cause of illness and death, and its clinical significance is increasing as the HIV-infected population ages worldwide. Despite this, our understanding of the mechanisms underlying this condition is limited. Our objective is to improve our mechanistic understanding of COPD and lung function abnormalities seen in persons with HIV infection that would lead to a future study that tests new treatments for this important and growing clinical problem.

PI_NAMEs: HUANG, LAURENCE  (contact);HUNT, PETER W;LIN, JUE

PROGRAM_OFFICER_NAME: LIU, QIAN

PROJECT_TERMS: Abbreviations;Acute;Address;Age;Aging;Biological Markers;Biological Specimen Banks;Biology;biomarker panel;Blood;Blood Banks;Blood specimen;Bronchoalveolar Lavage;Bronchodilator Agents;Bronchoscopy;C-reactive protein;Carbon Monoxide;Cell Aging;Cessation of life;chemokine;Chronic;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Clinical;clinically significant;co-infection;Coagulation Process;cohort;Cytomegalovirus;Data;Diffusion;Enrollment;Fibrin;Foundations;Future;Goals;High Prevalence;HIV;HIV Infections;immune activation;Immunologic Markers;improved;Inflammation;inflammatory marker;insight;Interferons;Interleukin-6;Intervention Studies;Lead;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Lung;Lung Diseases;lung injury;Lymphocyte Activation;Macrophage Activation;Measurement;Measures;Mediating;Microbe;monocyte;Morbidity - disease rate;mortality;Names;novel;novel marker;novel therapeutics;Obstructive Lung Diseases;Participant;Pathogenicity;Pathway interactions;peripheral blood;personalized medicine;Persons;Phenotype;Pneumonia;Population;Prevalence;prevent;Protein Secretion;Pulmonary Emphysema;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Pulmonary function tests;Research Design;response;Risk Factors;Specimen;Spirometry;Telomerase;telomere;Testing;Therapeutic Intervention;Time;Uganda;Virus Diseases;Work

PROJECT_TITLE: Inflammation, Aging, Microbes, Obstructive Lung Disease and Diffusion Abnormalities (I AM OLD-DA) Study

STUDY_SECTION: HCCS

STUDY_SECTION_NAME: HIV Comorbidities and Clinical Studies Study Section[HCCS]


ADMINISTERING_IC: MD

ED_INST_TYPE: ORGANIZED RESEARCH UNITS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Narrative It has been well-documented that Black adults experience greater sleep difficulty and duration compared to White adults. Work-related stress, with its robust link to sleep deficiencies, may be a critical, but overlooked source of these racial inequalities in sleep. Through our proposed research, we will examine numerous types of work-related stress in relation to sleep and also clarify the possible biological link responsible for the impact that stress has on sleep.

PI_NAMEs: HICKEN, MARGARET TAKAKO (contact)

PROGRAM_OFFICER_NAME: GILLMAN, ARIELLE SAMANTHA

PROJECT_TERMS: 3-Dimensional;actigraphy;Acute;acute stress;Adult;American;Autonomic nervous system;Behavior;Biological;biological adaptation to stress;Biological Markers;biological systems;Biology;Black American;black men;Black race;black women;Blood Pressure;Characteristics;Chronic;Chronic stress;Data;Discrimination;Ecological momentary assessment;Economics;Emotional;equity, diversity, and inclusion;experience;Functional disorder;Growth;Health;health inequalities;Heart Rate;Hydrocortisone;hypothalamic-pituitary-adrenal axis;Inequality;infancy;Inflammation;Intervention;Labor Forces;Laboratories;Life;Link;Literature;Measures;Morbidity - disease rate;mortality;Occupational;Occupations;Patient Self-Report;poor sleep;professional atmosphere;psychosocial;Race;racial determinant;racial disparity;racial population;Reporting;Research;Role;rumination;Sampling;Sleep;Sleep Deprivation;sleep difficulty;sleep health;sleep quality;Source;Stress;Stress Tests;Stressful Event;stressor;System;Thinking;Time;vigilance;Work;Workplace

PROJECT_TITLE: Racial inequalities in sleep deficiencies: The role of stress in the workplace

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Narrative Numerous recent studies have consistently shown that likely no two cells in the human body have the same genomes, a phenomenon called somatic mosaicism. Mosaicism can be studied using various approaches, but the study of mutations directly in the cell promises a comprehensive characterization of mosaicism in any tissue. However, all existing methods have significant limitations for studying the genome in a cell. Here we propose to develop and test a hybrid approach, which allows comprehensive and accurate analysis of the cell’s genomes in various tissues of the human body.

PI_NAMEs: ABYZOV, ALEXEJ  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Anatomy;Autopsy;Benchmarking;biobank;Biopsy;Bladder;Bone Marrow Cells;Cell Line;Cell Proliferation;cell type;Cells;Characteristics;Chondrocytes;Clonal Expansion;Clone Cells;Cloning;Colon;Complex;Cornea;Cryopreserved Cell;Cytogenetics;Development;Disadvantaged;DNA;DNA amplification;DNA biosynthesis;Endothelial Cells;Epithelium;Equilibrium;Esophagus;Fibroblasts;Freezing;Frequencies;Genetic;Genome;genome analysis;Hair follicle structure;Haplotypes;Heart;Heterogeneity;Human;Human body;human tissue;Hybrids;In Vitro;Intestines;Joints;Kidney;Limb structure;Lung;melanocyte;Methods;Morphologic artifacts;mosaic;Mosaicism;Muscle Cells;Mutation;Mutation Detection;Nature;novel strategies;Organ;Pathway Analysis;Phase;Polymerase;preservation;Proliferating;proliferation potential;Protocols documentation;Repetitive Sequence;Scalp structure;single cell analysis;Skin;Skin Tissue;Somatic Mutation;stem cells;Stomach;success;System;Testing;Tissue Preservation;Tissues;whole genome;Work;zygote

PROJECT_TITLE: Hybrid approach for comprehensive mutation detection in a cell

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Genetics;Neurosciences;Substance Misuse

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: Project Narrative. In the United States, ~5% of the population have an alcohol-use disorder and alcohol mis- use is the third leading preventable cause of death. The exploration of how a neuron-specific, nonnuclear NFkB mediates alcohol responses needs to be explored because it provides a novel way for neuroimmune signaling to mediate the response of the nervous system to alcohol. Furthermore, understanding how an NF- kB could directly modulate synaptic activity may also contribute to our understanding of the origins of the un- usual consequences of neuroimmune dysregulation such as impaired brain function, the exacerbation or cause of mental illnesses, and neurologic complications of Covid-19 disease.

PI_NAMEs: ATKINSON, NIGEL S (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Adult;Affect;alcohol behavior;alcohol effect;alcohol misuse;alcohol response;alcohol sensitivity;alcohol use disorder;Alcoholic Intoxication;Alcohols;Antibodies;Area;Behavior;behavior influence;Behavioral;Binding;Biochemical;Biological Models;Biotin;Brain;brain dysfunction;Cause of Death;Cell Nucleus;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Co-Immunoprecipitations;combat;COVID-19 complications;Cytoplasm;Data;density;dimer;Dimerization;Disease;Drosophila genus;Drosophila melanogaster;Epitopes;Ethanol;experimental study;fly;Fractionation;Ganglia;Gene Expression;Genes;genetic manipulation;Genetic Transcription;Human;Image;Immune;immune activation;Immune response;Immune system;Immunity;Immunoprecipitation;Individual;Infection;Label;Learning;Ligase;Lobe;Location;Mammals;Mass Spectrum Analysis;Mediating;Memory;Mental disorders;Messenger RNA;Mushroom Bodies;mutant;Mutation;Nervous System;Neuroimmune;Neurologic;Neurons;neurotransmission;NF-kappa B;non-genomic;novel;Nuclear;Nuclear Localization Signal;Nuclear Protein;Output;Pathway interactions;Peripheral;Population;Positioning Attribute;preference;Protein Isoforms;protein protein interaction;Proteins;Publishing;Reliability of Results;Reproducibility;response;Risk Factors;RNA Splicing;Sedation procedure;segregation;Signal Pathway;Signal Transduction;Stains;Synapses;Synaptic plasticity;Toll-like receptors;transcription factor;Transcriptional Activation Domain;United States;Variant;Work

PROJECT_TITLE: Identification of the protein:protein interactions of a non-nuclear NFKB that modulates ethanol sensitivity.

STUDY_SECTION: AA

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_DEPT: PSYCHIATRY

ORG_NAME: STANFORD UNIVERSITY

PHR: Public relevance Ensuring adherence to cognitive training is critical for understanding the effect of cognitive training in dementia prevention.

PI_NAMEs: HEFFNER, KATHI L;LIN, FENG VANKEE (contact)

PROGRAM_OFFICER_NAME: HARRELL, ERIN

PROJECT_TERMS: Adherence;Alzheimer's disease related dementia;amnestic mild cognitive impairment;Arousal;Breathing;Breathing Exercises;clinically relevant;Cognitive;Cognitive aging;cognitive enhancement;cognitive training;comparison group;comparison intervention;Data;Data Collection;deep learning model;Dementia;design;Development;Dimensions;Dose;Ensure;Facial Expression;Failure;Frequencies;Functional disorder;functional improvement;Functional Magnetic Resonance Imaging;group intervention;Guided imagery;Health;heart rate variability;high risk;Home;Impaired cognition;improved;Informal Social Control;Intervention;intervention effect;Intervention Studies;lifestyle data;lifestyle factors;Long-Term Effects;Magnetic Resonance Imaging;Measures;mild cognitive impairment;Monitor;Negative Valence;Nerve Degeneration;Neurocognitive;Nonpharmacologic Therapy;novel;Outcome;Participant;Pathway interactions;Patient Self-Report;Pattern;personalized predictions;Play;pre-clinical;predictive modeling;Prefrontal Cortex;prevent;Prevention;Prevention strategy;processing speed;Psyche structure;Reaction Time;Recording of previous events;Regimen;Relaxation;Research;Rest;Role;Sampling;social culture;Testing;Time;Training;Training Programs;Video Recording;Vision

PROJECT_TITLE: vmPFC's role in adherence to cognitive training

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: SPELMAN COLLEGE

PHR: PROJECT NARRATIVE The rationale for this project is that identification of determinants of academic achievement among an economically diverse sample of African American children and examination of the impact of COVID-19 can be used in developing treatments, interventions, or policies concerning early childhood development and education for this understudied population, thereby contributing to enhancing the health and outcomes of children in this nation. This study will therefore have significant impact on the developmental outcomes of young children.

PI_NAMEs: BLANKSON, ARABA NAYENA (contact)

PROGRAM_OFFICER_NAME: MUJURU, PRISCAH

PROJECT_TERMS: Academic achievement;Achievement;Address;African American;Area;Child;Cognition;cognitive process;cognitive skill;cohort;Conflict (Psychology);COVID-19;COVID-19 impact;COVID-19 pandemic;Crystallization;Development;early childhood;Education;elementary school;Emotional;Environment;executive function;experience;follow-up;Future Teacher;Goals;Health;high school;Home;Home environment;improved;Individual;Instruction;Intelligence;Intervention;kindergarten;Knowledge;Life;Liquid substance;Low income;mathematical ability;Mathematics;Natural experiment;Nursery Schools;Outcome;Pathway interactions;Play;Policies;Population;Predictive Factor;Process;Productivity;Reading;reading ability;recruit;Research;Research Project Summaries;Role;Sampling;school environment;Schools;second grade;Societies;Socioeconomic Status;socioeconomics;success;tenth grade;Testing;third grade;Uncertainty;Underserved Population

PROJECT_TITLE: Early education and later achievement: The impact of COVID-19 on educational attainment of African American children

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The proposed RCMI Coordinating Center will serve as a national resource to advance the science of minority health and health disparities through coordination of intellectual exchange and collaborative interactions that enhance research capacity and competitiveness of the RCMI U54 Centers.

PI_NAMEs: CHANG, SANDRA PERREIRA;OFILI, ELIZABETH O. (contact);SARPONG, DANIEL F;TCHOUNWOU, PAUL B.

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Acceleration;Award;Basic Science;Behavioral Research;Behavioral Sciences;Biological;Biomedical Research;career development;central database;Clinical and Translational Science Awards;clinical infrastructure;Clinical Research;Clinical Sciences;Collaborations;Common Data Element;Communication;community engaged approach;community engagement;community organizations;community partners;Consultations;Core Facility;culturally appropriate intervention;Development;Educational workshop;effective intervention;Equipment;ethnic disparity;Evaluation;expectation;experience;Fostering;Funding;geographic disparity;Grant;health disparity;implementation facilitation;improved;Information Technology;Infrastructure;Institution;inter-institutional;Marketing;Measures;meetings;Mentors;Methodology;minority health;minority health disparity;Minority-Serving Institution;Modeling;Monitor;National Center for Advancing Translational Sciences;National Institute of General Medical Sciences;National Institute on Minority Health and Health Disparities;Online Systems;outreach;participant retention;Patient Recruitments;Performance;Pilot Projects;Principal Investigator;Productivity;Program Evaluation;programs;Research;Research Activity;Research Design;Research Infrastructure;Research Personnel;research study;Resources;Science;Scientist;searchable database;social health determinants;success;symposium;Translational Research;Visit

PROJECT_TITLE: Research Centers in Minority Institutions (RCMI) Coordinating Center


ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE In this application, we propose a critical development of a duplex-seq-based single-cell whole- genome sequencing method that will achieve high accuracy and high coverage in detecting somatic mutations in single cells and the corresponding dual-omics chemistry that allows simultaneous transcriptome profiling and accurate detection of somatic mutations of single cells. To meet the goal of large-scale profiling of somatic mosaicism set by the SMaHT program, we will also develop a high-throughput platform for this chemistry with the innovative picoinjection system. The large-scale single-cell dual omics profiling of both genome and transcriptome will allow us to effectively construct the lineage tree of single cells, leading to the large-scale characterization of different branches/clones in normal tissues and the phenotypical difference between the different branches/clones, and the associated somatic mutations that drive these differences.

PI_NAMEs: ZONG, CHENGHANG  (contact)

PROJECT_TERMS: age related;Aging;Bioinformatics;Biological Assay;Biological Process;Cells;Cellular Assay;Chemistry;cost;Data;Data Analyses;de novo mutation;design;Detection;Development;Disease;Dissection;DNA;DNA Damage;Encapsulated;Event;experience;Frequencies;Future;Genome;genome sequencing;Genomic DNA;genomic profiling;Goals;Grant;Heterogeneity;High-Throughput Nucleotide Sequencing;Human;human disease;improved;Individual;Informatics;innovation;Life;Malignant Neoplasms;Measurement;medical specialties;method development;Methods;Microfluidics;Mosaicism;multiple omics;Mutation;Mutation Detection;nano;Nerve Degeneration;Normal tissue morphology;Phase;Phenotype;Productivity;programs;Publishing;Recovery;Resolution;RNA;scale up;Single Nucleotide Polymorphism;single-cell RNA sequencing;Somatic Mutation;Source;Standardization;System;Technology;Tissues;tool;transcriptome;transcriptomic profiling;Trees;Validation;Variant;whole genome;Work

PROJECT_TITLE: Develop accurate high-coverage and high-throughput single-cell Duplex-seq chemistry and multi-omics platforms for simultaneous profiling of somatic mutation and the transcriptome in single human cells


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: KINGSTON

ORG_NAME: UNIVERSITY OF RHODE ISLAND

ORG_STATE: RI

PHR: PROJECT NARRATIVE Reactive species from lipid peroxidation generated under disease conditions damage DNA and form etheno lesions, which are strongly cytotoxic, mutagenic, and carcinogenic. This project will characterize the repair of these etheno adducts by enzymes across two distinct pathways: base excision repair and direct reversal repair. Results will identify the differential repair fingerprints of such lesions and inform future translational studies that capitalize on these repair mechanisms to protect against genomic instability.

PI_NAMEs: DELANEY, SARAH ;LI, DEYU  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TERMS: adduct;Affect;Alkylation;alpha ketoglutarate;Amino Acid Sequence;base;Base Excision Repairs;cancer risk;carcinogenesis;carcinogenicity;Carcinogens;Cells;Chromatin;Chronic;chronic infection;clinically relevant;Clip;Complex;Core Protein;cytotoxic;Data;Dealkylation;Development;Dioxygenases;Discipline;Disease;ds-DNA;Enzymes;epigenetic marker;Epigenetic Process;Eukaryotic Cell;Excision Repair;experimental study;Family;Fingerprint;flexibility;Future;Genetic;genome integrity;Genomic Instability;Goals;Health;Histones;Human;Hydroxyl Radical;improved;in vivo;Infection;Inflammation;Inflammatory;innovation;Knowledge;Large Intestine Carcinoma;Lesion;Link;Lipid Peroxidation;Lung Adenocarcinoma;Malignant Neoplasms;member;Methods;Molecular;Mutation;N-terminal;Neoplastic Cell Transformation;next generation;novel;Nucleosome Core Particle;Organism;Oxidative Stress;Pathway interactions;Pattern;Poisson Distribution;Population;Positioning Attribute;Process;Productivity;Proteins;Proteolytic Processing;Reaction;repair enzyme;repaired;Reporting;Research;Research Project Grants;response;Site;Tail;Techniques;Testing;Therapeutic;translational potential;translational study;United States National Institutes of Health;Universities;Variant;Vinyl Chloride;Work

PROJECT_TITLE: NIH resubmission Deyu Li - Etheno adductome and repair pathways

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: Project narrative: Neuromesodermal progenitors are an undifferentiated vertebrate embryonic cell type that generates spinal cord, skeletal muscle, and other mesodermal cell types. This proposal will use zebrafish embryos to identify mechanisms of canonical Wnt signaling and Sox2 interactions, and to understand how cell cycle phase impacts normal cell fate and cell behavior. Our results will further develop knowledge of NMP biology to aid in their use in regenerative medicine and reveal broadly conserved signaling and cell biological mechanisms important for understanding cancer and other human diseases.

PI_NAMEs: MARTIN, BENJAMIN L (contact)

PROJECT_TERMS: arm;Behavior;Biological;Biology;Biosensor;cell behavior;Cell Cycle;Cell Differentiation process;Cell Maintenance;Cell model;cell motility;cell type;Cells;Cellular biology;Cyclin-Dependent Kinases;Development;Disease;Ectoderm;Embryo;Family;G1 Phase;G2 Phase;gastrulation;Gene Expression;Generations;genome-wide analysis;Germ Layers;human disease;improved;In Vitro;in vivo;insight;Invaded;Knowledge;Maintenance;Malignant Neoplasms;Mediating;Mesoderm;Mesoderm Cell;Molecular;Molecular Biology;Normal Cell;notochord;Pathway interactions;Phase;Play;Postdoctoral Fellow;progenitor;Receptor Activation;Regenerative Medicine;Research;Role;Signal Pathway;Signal Transduction;Skeletal Muscle;Source;Spinal Cord;stem cell biology;Stem Cell Development;stem cells;TCF Transcription Factor;Techniques;Tissues;transcription factor;Transcriptional Regulation;Transgenic Organisms;Undifferentiated;vertebrate embryos;WNT Signaling Pathway;Work;Zebrafish

PROJECT_TITLE: Molecular and Cell Biology of Neuromesodermal Progenitors


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: The NCATS KL2 career development programs are foundational to developing the next generation of clinical and translational researchers and ensuring that they achieve career success and research independence. The University of Cincinnati Center for Clinical and Translational Science and Training has a strong record of accomplishment in training KL2 Scholars: of the 20 graduates, 95% are still conducting clinical and translational research, 100% have served as Principal Investigator or Co-Investigator of an externally-funded grant, and the sum of direct costs generated by Scholars’ grants I $109,286,934. We propose to 1) train the next generation of clinical and translational investigators through mentored research experiences, core methods and skills development, and tailored experiential learning opportunities; 2) develop engaged, diverse junior investigators who have sustainable translational research careers; and 3) promote the translation of Scholar research into improved health outcomes across the lifespan, through innovative training strategies.

PI_NAMEs: ZELLER, MARGARET H (contact)

PROGRAM_OFFICER_NAME: GOPAL-SRIVASTAVA, RASHMI

PROJECT_TERMS: 3-Dimensional;Active Learning;Address;American Heart Association;Appointment;Award;Biomedical Research;burnout;career;career development;Clinical;clinical center;Clinical Investigator;Clinical Research;Clinical Sciences;Collaborations;Communication;Communities;Department of Defense;design;Dimensions;Direct Costs;Discipline;disparity reduction;Educational workshop;Ensure;Ethnic Origin;evidence base;experience;Faculty;Fostering;Funding;Future;Gender;Goals;Grant;Health;health outcome disparity;Health system;improved;Industry;innovation;Institution;International;Journals;K-Series Research Career Programs;Leadership;Learning;life span;Manuscripts;Measures;meetings;Mentors;method development;multidisciplinary;National Center for Advancing Translational Sciences;next generation;Outcome;Pathway interactions;population health;Positioning Attribute;Principal Investigator;Program Development;Program Evaluation;programs;Publishing;Race;recruit;Research;Research Ethics;Research Methodology;Research Personnel;Research Project Grants;scale up;Scholars Program;Science;Secure;Site;skill acquisition;skills;success;Sum;Training;Training Programs;Translational Research;translational scientist;Translations;Universities;Vision;Woman;Work;workforce needs

PROJECT_TITLE: KL2 Training Program


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Aging;American Indian or Alaska Native;Cerebrovascular;Climate-Related Exposures and Conditions;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Household Energy Combustion;Health Effects of Indoor Air Pollution;Neurosciences;Racial and Ethnic Minority Health Research

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE Wildland fire disasters raged throughout the western US in recent years, continuing a trend for increasing frequency and severity of such events driven by climate change. Our recent studies with naturally-occurring wildland fire smoke (WFS) exposures from the California October 2020 wildfires demonstrate clear neuroinflammatory outcomes in otherwise healthy mice. In the present renewal proposal, we will utilize precise, laboratory-based exposure systems to address pulmonary and neuroinflammatory risks of wood smoke from metals-contaminated biomass obtained from these regions.

PI_NAMEs: CAMPEN, MATTHEW J (contact);NOOR, SHAHANI

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acceleration;Acclimatization;Acute;Address;Aging;aging population;anthropogenesis;Area;Arizona;Arsenic;Astrocytes;Automobile Driving;Biomass;biomass fuel;Brain;Cadmium;California;CCL2 gene;Cell Adhesion Molecules;Cell surface;Cells;cerebrovascular;Chemicals;Chromium;Circulation;climate change;Communities;Consumption;Data;Development;Diet;dietary;Elderly;Endothelial Cells;endothelial dysfunction;Endothelium;environmental stressor;Event;Exhibits;Exposure to;Fire - disasters;first responder;Flow Cytometry;Foundations;Frequencies;Household;Immune;immune cell infiltrate;Inflammation;Inflammatory;Inhalation;Inhalation Exposure;Injury;Intercellular adhesion molecule 1;Knowledge;Laboratories;Learning;Leukocytes;lipid mediator;Lung;Metal exposure;Metals;Microglia;Mining;Modeling;Molecular;Mus;Nature;Navajo;Nerve Degeneration;neuroinflammation;neurovascular;neurovascular unit;neutrophil;New Mexico;Nickel;Nuclear;Outcome;Particulate Matter;Pathway interactions;PECAM1 gene;Peripheral;Persons;Phenotype;Pueblo Race;Pulmonary Inflammation;recruit;Resolution;response;Risk;Role;Sampling;Saturated Fatty Acids;Severities;Site;Smoke;smoke inhalation;Source;Stimulus;System;Testing;Therapeutic;Therapeutic Intervention;Time;Toxic effect;toxic metal;trend;Uranium;Urine;Utah;Vanadium;Vascular Cell Adhesion Molecule-1;Wildfire;Wood material;wood smoke;Work

PROJECT_TITLE: Contaminant Metal Content in Wildfire Smoke and Neuroinflammation

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Machine Learning and Artificial Intelligence

ORG_DEPT: PEDIATRICS

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Genetic mutations accumulate in every cell of our bodies throughout our lives, but before mutations become permanent in both strands of a DNA molecule, they begin as mutation or damage to just one of the two strands. This study will develop a new technology to detect for the first time many kinds of mutations and damage to just one of the two strands of DNA. This will help us understand the first step of the mutation process, why mutations occur differently in different parts of the body, and factors that affect how our DNA mutates.

PI_NAMEs: EVRONY, GILAD DAVID (contact)

PROJECT_TERMS: Achievement;Address;Affect;Aging;Automation;Autopsy;base;Biological Assay;Body part;Catalogs;Categories;Cells;Characteristics;Cloud Computing;Collection;comparative efficacy;computational pipelines;cost;Cost Effectiveness Analysis;Data;deep neural network;design;Detection;Development;Dissection;DNA;DNA amplification;DNA Damage;DNA Modification Process;DNA Repair Disorder;DNA Sequence;DNA Sequence Alteration;DNA sequencing;ds-DNA;Elements;Engineering;Ensure;Environmental Health;Event;Genetic Anticipation;Genetic Diseases;Genome;Goals;Human body;human tissue;improved;In Vitro;innovation;insertion/deletion mutation;Kinetics;Laboratories;Libraries;Liquid substance;machine learning model;Malignant Neoplasms;Measures;Methods;Microdissection;Modification;Morphologic artifacts;mosaic;mosaic variant;Mosaicism;Mutagens;Mutate;Mutation;new technology;Oligonucleotides;parallelization;Participant;Pattern;Phase;Physiology;Polymerase;portability;Preparation;Process;repaired;Reproducibility;Research;Retroelements;Robot;Role;Sampling;single cell sequencing;single molecule;Single-Stranded DNA;Source;Standardization;stem;Technology;Testing;Time;tissue repair;Tissue Sample;Tissues;Validation;Variant;Work

PROJECT_TITLE: Ultra-High Fidelity Single-Molecule Profiling of Mosaic Double- and Single-Strand DNA Mutations and Damage


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Data Science;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Sexually Transmitted Infections

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Previous studies have generated large collections of omics datasets associated to HPV+ oral cancer. We hypothesize that integration of existing datasets could improve biomarker identification and gain novel insights. We will organize integrative analysis to identify HPV-specific biomarkers in HPV+ oral cancer by properly stitching multi-omics datasets, handling batch effects and performing integration and validation.

PI_NAMEs: TENG, MINGXIANG  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Accounting;Anatomy;Biological Markers;biomarker identification;Cancer cell line;cancer type;Cancerous;Candidate Disease Gene;candidate marker;Cell Line;Cells;cellular transduction;ChIP-seq;Chromatin;Clinical;Collaborations;Collection;Data;Data Analyses;data integration;data modeling;Data Science;Data Set;Discrimination;Dryness;Ensure;epigenomics;Epithelial Cells;Epithelium;Europe;Excision;exome;experience;experimental study;fitness;Future;Genes;Genetic Markers;genomic biomarker;genomic profiles;Genomics;Growth;Heterogeneity;heterogenous data;High-Throughput Nucleotide Sequencing;HPV negative;HPV positive;Human Herpesvirus 4;Human papilloma virus infection;Human Papillomavirus;improved;Infection;insight;knock-down;Knock-out;Knowledge;laboratory experiment;malignant mouth neoplasm;Malignant Neoplasms;malignant oropharynx neoplasm;Methods;Molecular;molecular dynamics;Multiomic Data;Mutation;Nasopharynx;Nature;Neoplasm Metastasis;neoplastic cell;next generation sequencing;North America;novel;novel therapeutics;Oncogenes;Oncogenic;Oncogenic Viruses;Oral;oral biology;oral carcinogenesis;oral cavity epithelium;Oropharyngeal;Pathway interactions;Pattern;PIK3CG gene;Predisposition;Proteins;Retinoblastoma Protein;Role;Sample Size;Signal Pathway;Signal Transduction;Site;specific biomarkers;Testing;The Cancer Genome Atlas;TNF gene;TP53 gene;transcriptome;transcriptome sequencing;transcriptomics;Translating;trend;tumor;Tumor Suppressor Proteins;tumorigenesis;Validation;Viral;Viral Load result;Virus;Virus Diseases

PROJECT_TITLE: Integrative analysis to identify genomic biomarkers in HPV positive oral cancer


ORG_CITY: OKLAHOMA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: PROJECT NARRATIVE Relevance to Public Health This grant proposal will develop a robust and comprehensive analysis of the expression status of a previously undefined mitochondrial lipid kinase, AGK, in chronic lymphocytic leukemia (CLL) which we have detected recently in CLL cells however; functional implication of this aberrantly expressed lipid kinase in CLL oncogenesis remains unknown. The proposed studies are dedicated in novel and important directions: 1) to establish if aberrant expression of AGK in CLL cells represents high-risk CLL patients' cohort for aggressive disease and/or predicts time to therapy; 2) delineate the mechanism of AGK upregulation in CLL cells; 3) define the function of AGK in CLL cell survival and therapeutic outcome of the patients and finally, 4) assess the feasibility of targeting aberrantly expressed AGK to induce apoptosis in vitro in leukemic B-cells from previously untreated CLL patients, and in vivo in a CLL-specific established mouse model. In total, the information gained on the aberrantly upregulated AGK in CLL cells in relation to disease progression and our goal on developing increasing rationale for the use of AGK-inhibitor alone or in combination with the current targeted therapies for CLL has great potential to impact and improve public health.

PI_NAMEs: GHOSH, ASISH KUMAR (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Accounting;Adult;Agammaglobulinaemia tyrosine kinase;Antigens;Applications Grants;Automobile Driving;B lymphoid malignancy;B-Cell Activation;B-Cell Antigen Receptor;B-Lymphocytes;BCL2 gene;Behavior;Binding;Biological;Biological Process;Blood;Bone Marrow;cell growth;Cell Proliferation;Cell Survival;cell type;Cells;Cellular biology;Cervical Squamous Cell Carcinoma;Chronic Lymphocytic Leukemia;chronic lymphocytic leukemia cell;Clinical;clinical heterogeneity;cohort;Cytoplasm;cytotoxic;Data;Dedications;Diagnosis;Diglycerides;Disease;Disease Progression;Early treatment;Epigenetic Process;Esophageal Squamous Cell Carcinoma;Event;FRAP1 gene;Genetic;Genetic Transcription;Goals;Heterogeneity;high risk;Human;improved;In Vitro;in vivo;Indolent;Induction of Apoptosis;inhibitor;inhibitor therapy;innovation;insight;Investigation;JAK2 gene;kinase inhibitor;large cell Diffuse non-Hodgkin's lymphoma;leukemia;Lipids;Liposomes;lymph nodes;LYN gene;lysophosphatidic acid;Malignant - descriptor;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Mediating;Mediator;Mitochondria;mitochondrial membrane;Molecular;Monoglycerides;mouse model;novel;Nuclear;Oncogenes;Oncogenic;Oral;Organ;overexpression;Pathogenesis;Pathway interactions;Patient-Focused Outcomes;Patients;Phosphatidic Acid;Phosphotransferases;PI3K/AKT;PIK3CG gene;Process;Production;prognostic;Proliferating;Proto-Oncogene Proteins c-akt;PTEN gene;Public Health;Receptor Inhibition;Receptor Signaling;Regulation;relapse patients;Resistance;Richter's Syndrome;Risk Factors;Role;Signal Transduction;Signaling Molecule;Small Interfering RNA;Spleen;Squamous cell carcinoma;STAT3 gene;survival outcome;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapy outcome;therapy resistant;Time;Transgenic Mice;Treatment outcome;tumor;Tumor Burden;tumorigenesis;Up-Regulation

PROJECT_TITLE: Pro-Oncogenic Role of a Mitochondrial Lipid Kinase in CLL


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Radiation Oncology;Rare Diseases

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE Cells expressing the fibroblast activating protein alpha (FAP) are emerging as a potent driver of GBM immune evasion. Our proposed studies aim to define the immunosuppressive properties of FAP+ cells and to shed light on a novel actionable target to restore brain immunity by inhibiting FAP in the context of RT.

PI_NAMEs: VANPOUILLE-BOX, CLAIRE ISABELLE (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Abscopal effect;Adult;Alpha Cell;anti-PD-1;Brain;Brain Neoplasms;Breast Cancer Model;cancer therapy;Carcinoma;CD8-Positive T-Lymphocytes;CD8B1 gene;cell type;Cells;Colorectal Cancer;cytotoxic;Data;Disease;effective therapy;Effector Cell;Exclusion;Exhibits;FDA approved;fibroblast activation protein alpha;Fibroblasts;Flow Cytometry;Gene Expression Profile;Glioblastoma;Human;Immune;immune cell infiltrate;Immune Evasion;immune resistance;Immune response;Immune system;Immunity;immunogenic;immunogenicity;Immunologic Stimulation;Immunosuppression;Impairment;improved;In Vitro;in vivo;Infiltration;innovation;irradiation;ITGAX gene;Knowledge;Lymphocytic Infiltrate;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Mediating;member;Membrane;Microglia;Microsatellite Repeats;Modality;Modeling;Morphology;mouse model;Mus;Myeloid Cells;Neoplasms;novel;novel strategies;novel therapeutic intervention;Patients;Peptide Hydrolases;pharmacologic;Phenotype;pre-clinical;prevent;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteins;Radiation therapy;recruit;Recurrence;Recurrent tumor;Reporting;Research;Resistance;resistance mechanism;Role;Serine;Serine Protease;Signal Transduction;single-cell RNA sequencing;Solid Neoplasm;Sorting;standard of care;Stimulus;Stromal Cells;Surface;synergism;T-Lymphocyte;temozolomide;Testing;Transforming Growth Factor beta;Treatment Efficacy;tumor;Tumor Escape;Tumor Immunity;tumor microenvironment;tumor-immune system interactions;Urothelium;VEGFA gene;Work

PROJECT_TITLE: Role of FAP-positive cells in immune response to irradiated glioblastoma

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Narrative Memory impairment is a core deficit accompanying many neurological disorders. This proposal will examine how a simple nervous system encodes model-based memories constructed on inferred values (sensory preconditioning). These experiments will add to the knowledge base required for the rational design of treatment for memory disorders.

PI_NAMEs: CERVANTES SANDOVAL, ISAAC  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Animals;Association Learning;base;Behavior Control;Behavioral;Biological;Brain;Brain Diseases;Calcium;Categories;Cells;Complex;conditioned fear;Conditioned Reflex;conditioning;connectome;Cues;Data;Desire for food;Development;Dopamine;Dopamine Receptor;dopaminergic neuron;Drosophila genus;Environment;experience;experimental study;falls;Feedback;fly;Functional Imaging;genetic manipulation;Goals;Habits;Human;Imaging Techniques;insight;Knowledge;knowledge base;Learning;Link;Memory;Memory Disorders;memory encoding;Memory impairment;Modeling;Molecular;Mushroom Bodies;Nature;Nervous System;Nervous System Disorder;Neurobiology;Neurons;novel;Odors;optogenetics;Output;Phase;phase 3 testing;Policies;preconditioning;Predictive Value;Process;rational design;Research;Resolution;response;Role;Sensory;Shock;Signal Transduction;Stimulus;stimulus interval;Structure;Synapses;Synaptic plasticity;System;Testing;theories;therapy design;Training

PROJECT_TITLE: Neurobiology of Sensory Preconditioning

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

ORG_STATE: NC

PHR: PROJECT NARRATIVE/PUBLIC HEALTH RELEVANCE STATEMENT This grant is aimed at understanding how cells adjust their growth in response to mechanical forces. This is an important question because the cellular response to force is altered in numerous diseases, ranging from cancer to fibrosis to cardiovascular disease. Deciphering the pathways by which cells respond to mechanical forces may thus reveal new targets for future therapies.

PI_NAMEs: GUILLUY, CHRISTOPHE DANIEL (contact)

PROGRAM_OFFICER_NAME: XU, JIANHUA

PROJECT_TERMS: Acceleration;Actomyosin;Address;Anaphase;Biochemical;biophysical tools;Biophysics;Calcium;Cardiovascular Diseases;Cell Cycle;Cell Cycle Progression;Cell Cycle Regulation;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Complex;Cytoskeleton;Disease;Event;experience;Fibrosis;Filament;Functional disorder;Future;G1/S Transition;Gene Expression;Grant;Growth;Homeostasis;Image;innovation;Interphase;Investigation;Malignant Neoplasms;mechanical force;Mechanics;mechanotransduction;Mediating;Metaphase;Mitosis;Mitotic spindle;Molecular;Morphology;Normal Cell;Nuclear;Nuclear Envelope;Pathogenesis;Pathologic;Pathway interactions;pharmacologic;Physiological;Process;Proliferating;Proteomics;public health relevance;response;S phase;sensor;Signal Pathway;Signal Transduction;spatiotemporal;Stimulus;Testing;Tissues;transcription factor;Transcription Factor AP-1;transmission process;Up-Regulation;Work

PROJECT_TITLE: Regulation of Cell Cycle progression by the nuclear envelope

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: PROJECT NARRATIVE Loneliness affects a large proportion of older adults and has been linked with increased risk for dementia, particularly Alzheimer’s disease. The proposed project will examine the directionality of relationships between loneliness and cognitive function and investigate biological mechanisms linking loneliness with cognitive decline. The findings will clarify the role of loneliness as a risk factor for future cognitive decline or an indicator of cognitive dysfunction prior to the onset of dementia, supporting the development of early detection and dementia risk reduction strategies.

PI_NAMEs: GRAHAM-ENGELAND, JENNIFER ELISE (contact)

PROGRAM_OFFICER_NAME: TREVINO, MELISSA

PROJECT_TERMS: Acceleration;Address;Affect;Age;age group;aged;Aging;Alzheimer's Disease;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Animal Model;Behavioral;Biological;Biological Markers;Blood specimen;Brain-Derived Neurotrophic Factor;Cerebrum;Clinic;Cognitive;cognitive change;cognitive function;cohort;Collection;Country;County;Data;Data Set;Dementia;dementia risk;design;Development;Disease;Early Diagnosis;Ecological momentary assessment;Foundations;Future;Genetic Polymorphism;Health;Human;human old age (65+);Impaired cognition;improved;Incidence;Income;Individual;Intervention;Life;life span;Light;Link;Loneliness;lonely individuals;Measurement;Mediating;mild cognitive impairment;multilevel analysis;Nerve Degeneration;neurobiological mechanism;Neurobiology;Neurodegenerative Disorders;neurofilament;neurogenesis;neuropathology;older adult;Outcome;Parents;Participant;Pathway interactions;Phenotype;Plasma;pre-clinical;Probability Samples;programs;psychosocial;recruit;response;Risk;Risk Factors;Risk Reduction;Role;Sampling;Series;Serum;Specific qualifier value;tau Proteins;Time

PROJECT_TITLE: The role of loneliness in cognitive decline and risk for dementia

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Complementary and Integrative Health;Mental Health;Opioids;Pain Research;Patient Safety;Women's Health Research

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: PROJECT NARRATIVE The proposed randomized trial is relevant to public health, because incorporating hypnosedation (HS) during breast cancer surgery provided by a clinical team member will allow patients to avoid general anesthesia. Not only do we expect HS to improve patient reported outcomes (pain, anxiety, nausea, fatigue, and satisfaction), we also expect that replacing general anesthesia with HS will lead to less use of opioids during and after surgery, fewer physiological perturbations during surgery, and faster postoperative recovery. Thus, the proposed research is relevant to the part of NIH’s mission that pertains to addressing the opioid epidemic and understanding the bidirectional relationship between psychological and physiological responses to cancer treatment.

PI_NAMEs: COHEN, LORENZO  (contact)

PROGRAM_OFFICER_NAME: STRECK, BRENNAN PARMELEE

PROJECT_TERMS: Absence of pain sensation;absorption;Address;Affect;Analgesics;Anesthesia procedures;Anxiety;biopsychosocial;Breast biopsy;Breast Cancer Treatment;breast lumpectomy;breast surgery;cancer diagnosis;cancer surgery;cancer therapy;Cellular Immunity;Certified registered nurse anesthetist;Clinical;clinical practice;cost;cost effective;Data;Day Surgery;Dose;economic evaluation;efficacy evaluation;Europe;expectation;Fatigue;Fentanyl;General Anesthesia;hemodynamics;Hypnosis;Ileus;Immunosuppression;Impaired cognition;improved;improved outcome;Individual Differences;Infusion procedures;instrumentation;Intervention;intervention effect;Intravenous Anesthesia;Laryngeal Masks;Light;Local anesthesia;Local Anesthetics;Malignant Breast Neoplasm;Medical;Medical Care Costs;member;men;Methods;Mission;morphine equivalent;Nausea;Neurologic;Nonpharmacologic Therapy;Nurses;Operative Surgical Procedures;Opioid;opioid epidemic;opioid misuse;opioid sparing;opioid use;outcome prediction;Pain;pain sensitivity;Patient Outcomes Assessments;Patient Self-Report;Patients;Pharmaceutical Preparations;Physiological;Population;Postoperative Nausea and Vomiting;Postoperative Period;postoperative recovery;Procedures;Process;Propofol;Pruritus;psychologic;Psychological Stress;Psychosocial Factor;Public Health;Randomized;randomized trial;Recovery;Recovery Room;Reporting;Research;response;Risk;satisfaction;Schedule;Sentinel Lymph Node Biopsy;Serious Adverse Event;side effect;standard care;standard of care;Surgical complication;Techniques;Testing;Thinking;Time;Time and Motion Studies;time use;trait;treatment as usual;tumor;Unconscious State;United States;United States National Institutes of Health;Urinary Retention;Vomiting;Woman;women's diagnosis;Women's trial;wound healing

PROJECT_TITLE: Opioid-Sparing Effects of Nurse-Delivered Hypnosis During Breast Cancer Surgery

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Pre-exposure prophylaxis (PrEP) is a highly efficacious, user-controlled, evidence-based HIV prevention option, which has not been rolled out for key populations in India. The present study will provide crucial information about how to engage and retain highly stigmatized populations in PrEP care in India by testing the acceptability, feasibility, and sustainability of an adapted WHO E-PrEP Implementation Tool. The findings from this implementation science study will aid in the scale-up of sustainable interventions to reduce HIV disparities among stigmatized groups across India.

PI_NAMEs: FEHRENBACHER, ANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: BANSAL, GEETHA PARTHASARATHY

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Adopted;Adoption;AIDS prevention;Applications Grants;Australia;barrier to care;biobehavior;California;care systems;career;Caring;chronic care model;Clinic;Collaborations;concept mapping;Continuity of Patient Care;Country;COVID-19;Data;design;digital;Discrimination;Doctor of Philosophy;Eastern Africa;Effectiveness;efficacy evaluation;eHealth;Epidemic;Epidemiologist;Evaluation;evidence base;Evidence based practice;experience;experimental analysis;Faculty;Family;Female;female sex worker;follow-up;Funding;gender minority group;gender minority health;global health;Goals;Health;health disparity;Healthcare;HIV;HIV disparities;implementation evaluation;implementation framework;implementation outcomes;implementation process;implementation science;implementation tool;Incidence;India;innovation;Intervention;Interview;Investments;Left;Los Angeles;male;marginalization;Mentors;Methodology;Methods;mobile computing;Modeling;Monitor;Nigeria;NIH Office of AIDS Research;novel;Occupations;Oral;organizational readiness;outreach;Patients;Persons;Pilot Projects;pilot test;Policies;Policy Maker;Population;pre-exposure prophylaxis;preference;Prevalence;prevention service;prototype;Provider;Psychiatry;public health research;Randomized, Controlled Trials;Records;Reporting;Research;research and development;Research Institute;Research Personnel;Research Priority;Risk;Rural;Safety;scale up;Science;Self Management;self testing;sex;Sexual and Gender Minorities;sexual minority group;Site;skills;social;social exclusion;South Africa;Southern Africa;staff intervention;Stigmatization;Strategic Planning;stressor;success;Testing;tool;Training;transgender;United States;United States National Institutes of Health;Universities;uptake;Vertebral column;Violence;Visualization;Work

PROJECT_TITLE: PrEP Implementation Science with Hard to Reach Populations in India

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-L(57)R]


NIH_SPENDING_CATS: Biotechnology;Cancer

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: PROJECT NARRATIVE Although proteasome inhibitors are currently used in the clinic against Multiple myeloma, this approach alone is insufficient for sustaining long-term remission in patients. DDI2 protease plays a major role in cancer cell survival during proteasome inhibition therapy. This proposal aims to identify inhibitors of DDI2 protease that can be used to increase the efficacy of proteasome inhibitors.

PI_NAMEs: KLEIGER, GARY L.;RADHAKRISHNAN, SENTHIL KUMAR  (contact);SERGIENKO, EDUARD A.

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Achievement;Acquired Immunodeficiency Syndrome;Address;Affect;Apoptosis;Applications Grants;Area;Binding;Biological Assay;Biophysics;cancer cell;Cancer Patient;cancer therapy;Catalytic Domain;Cell Survival;Cells;Cellular Assay;cheminformatics;Clinic;Clinical Trials;counterscreen;Data;Detection;Development;Disease remission;Dose;Drug Targeting;Dryness;Enzymes;Event;Exhibits;expectation;FDA approved;Fruit;Funding;Future;Genes;Goals;Grant;high throughput screening;HIV Protease;Human;immune modulating agents;Immune system;inhibitor;Length;Libraries;liquid chromatography mass spectrometry;Malignant Breast Neoplasm;Marketing;Measurement;Modality;multicatalytic endopeptidase complex;Multiple Myeloma;Mus;Normal Cell;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Play;Powder dose form;Predisposition;Production;programs;Protease Inhibitor;Proteasome Inhibition;Proteasome Inhibitor;protein degradation;Protein Kinase;Proteins;proteostasis;Protocols documentation;Recovery;Reproducibility;response;Risk;Role;scaffold;scale up;screening;side effect;Signal Transduction Pathway;small molecule inhibitor;synergism;System;targeted cancer therapy;Testing;Therapeutic;Transcript;transcription factor;tumor;tumor growth;Ubiquitin;Up-Regulation;Validation;Work;Xenograft Model

PROJECT_TITLE: Identification of small molecule inhibitors of the DDI2 protease

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR) T-cell therapies are emerging as a curative therapy for some patients with diffuse large B-cell lymphoma (DLBCL); however for the more than 60% of patients who do not have a complete response survival is measured in months. Recently, we identified the cell surface lymphotoxin beta receptor (LTBR) as a positive T-cell regulator that enhances CD19 CAR T-cell efficacy in vitro and in vivo; here, we will comprehensively explore LTBR as a T-cell activating strategy to maximize the intrinsic anti-tumor activity of CAR T-cells in relapsed or refractory (R/R) DLBCL. Our findings will inform the clinical development of next-generation CAR therapies with enhanced clinical efficacy for R/R DLBCL and possibly other diverse tumor types.

PI_NAMEs: DIEFENBACH, CATHERINE SIBYL;SANJANA, NEVILLE  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: activated B cell like;Alanine;Antigens;Antitumor Response;Autologous;B-Cell Activation;B-Cell NonHodgkins Lymphoma;B-Lymphocytes;Biological;Biological Assay;Cancer Burden;CAR T cell therapy;CD19 gene;CD28 gene;cell killing;Cell Line;Cell Physiology;Cell surface;Cells;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical development;clinical efficacy;Clinical Trials;curative treatments;cytokine;Data;Development;Disease;engineered T cells;Engineering;exhaust;exhaustion;FDA approved;Flow Cytometry;Genetic Transcription;Heterogeneity;Histology;immune resistance;Immunologic Memory;immunological synapse;Immunology;Immunosuppression;improved;improved outcome;In complete remission;In Vitro;in vivo;Inflammatory;Intervention;Kinetics;Laboratory Study;large cell Diffuse non-Hodgkin's lymphoma;leukemia;Libraries;Lymphocyte;Lymphoma;lymphotoxin beta receptor;Measures;Molecular Profiling;mouse model;multiple omics;Mus;Mutagenesis;Myelogenous;Myeloid Cells;Myeloid-derived suppressor cells;next generation;novel;Outcome;overexpression;Patients;peripheral blood;Population;prospective;Proteins;receptor;Refractory;Relapse;relapse patients;Research;Resistance;response;RNA;Sampling;Scanning;Signal Transduction;Specificity;stemness;Structure of germinal center of lymph node;T cell differentiation;T cell response;T-Cell Activation;T-Cell Lymphoma;T-Lymphocyte;Testing;Toxic effect;Translational Research;tumor;Tumor Burden;Variant;Work;Xenograft procedure;γδ T cells

PROJECT_TITLE: LTBR CARs as next-generation therapies for R/R lymphoma

STUDY_SECTION: CIC

STUDY_SECTION_NAME: Cellular Immunotherapy of Cancer Study Section[CIC]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Immunization;Infectious Diseases;Lung;Rare Diseases;Vaccine Related

ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Measles is increasing worldwide, is spread by aerosol and is highly infectious. However, knowledge of initiation of virus replication in the respiratory tract is incomplete. In this research proposal, we will identify the susceptible cells in the lung, how they become infected and the response to infection.

PI_NAMEs: PEKOSZ, ANDREW S. (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Abbreviations;Address;aerosolized;Aerosols;airway epithelium;Alveolar Macrophages;Apical;Area;attenuated measles virus;Bronchoalveolar Lavage;Cell Culture Techniques;Cell Differentiation process;Cells;Chimeric Proteins;Contracts;Cyclophilins;Data;Dendritic Cells;Disease;enhanced green fluorescent protein;Epithelial Cells;Epithelium;Exposure to;Extracellular Matrix;Family;Fibroblasts;Fluorescent in Situ Hybridization;Genome;Germ Cells;Giant Cells;Hemagglutinin;Human;human disease;Immunity;Immunization;In Vitro;in vivo;Infection;Interferons;Knowledge;Lipids;Lower respiratory tract structure;Lung;Lymphocyte;Lymphoid Tissue;Macaca;Macaca mulatta;Measles;Measles Vaccine;Measles virus;Morbidity - disease rate;Morbillivirus;mortality;Mucous body substance;Myeloid Cells;Nasal Epithelium;Nucleocapsid Proteins;parainfluenza virus;Paramyxovirus;Pathogenesis;Peptides;Population;Predisposition;prevent outbreaks;Proteins;receptor;Recombinants;Reporter;reproductive;Research Personnel;Research Proposals;Resistance;Respiration;respiratory;Respiratory syncytial virus;Respiratory System;Respiratory Tract Infections;response;RNA Viruses;Role;Route;Site;sphingosine 1-phosphate;Sphingosine-1-Phosphate Receptor;Surface;Tracheal Epithelium;transmission process;Upper respiratory tract;Vaccines;Viral;viral transmission;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Measles virus infection of the respiratory tract

STUDY_SECTION: VIRB

STUDY_SECTION_NAME: Virology - B Study Section[VIRB]