ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

PHR: Project Narrative Obesity is a major public health concern, as it increases the risk for diabetes, heart disease and certain forms of cancer. Obesity, particularly in its most severe form, has an extremely strong genetic basis. Unfortunately, most of the genes that predispose people to obesity, as well as the molecular and cellular pathways those genes participate in, remain unknown. This project builds on the expertise and established collaborative work of two investigators to illuminate how dysfunction of neuronal primary cilium, a specific sub-cellular compartment that functions as an intercellular antenna, causes obesity.

PI_NAMEs: REITER, JEREMY F;VAISSE, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Address;Adenylate Cyclase;Affect;Brain;Calories;Cell Surface Extensions;Cells;Cilia;ciliopathy;Communication;Coupled;CRISPR interference;CRISPR/Cas technology;Cyclic AMP;Cyclic AMP-Dependent Protein Kinases;Cytoplasm;Data;Defect;Desire for food;diabetes risk;Disease;experimental study;Funding;G-Protein-Coupled Receptors;Gene Expression;Genes;Genetic;genetic approach;genetic variant;GTP-Binding Protein alpha Subunits, Gs;Heart Diseases;Homeostasis;Human;Hyperphagia;Hypothalamic structure;in vivo;Inherited;insight;intercellular communication;Laboratories;Leptin;Ligands;Malignant Neoplasms;Melanocortin 4 Receptor;Melanocortin 4 receptor mutation;Molecular;mouse model;Mus;Mutation;Neuronal Dysfunction;Neurons;novel;Obesity;optogenetics;paraventricular nucleus;Pathway interactions;Persons;Positioning Attribute;Proteins;Public Health;receptor;receptor function;Receptor Signaling;Regulation;Research Personnel;Role;Second Messenger Systems;Signal Transduction;Surface;Susceptibility Gene;Synapses;targeted delivery;Testing;tool;trafficking;Work;α-Melanocyte stimulating hormone

PROJECT_TITLE: Obesity in ciliopathies: How neuronal primary cilia control appetite

STUDY_SECTION: POMD

STUDY_SECTION_NAME: Pathophysiology of Obesity and Metabolic Disease Study Section[POMD]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: La Jolla

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: Project Narrative Glioblastoma is the most common adult brain cancer and has remained incurable since it was first identified over two centuries ago. A central reason for this failure in treatment lies in the heterogenous and immunosuppressive nature of these malignancies, and its ability to evade the immune system from destruction. This proposal will identify how microglia and macrophages, the largest non-tumor component of the microenvironment, can adopt opposing “tumor killing/tumor promoting” activation states and how manipulation of these different states may redirect progressing glioblastoma toward regression.

PI_NAMEs: GARCIA-RIVERA, LIZMARIE  (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Address;Adopted;Adult;anti-CTLA4;anti-tumor immune response;Antigen Presentation;Antitumor Response;Architecture;Biology;Brain;Brain Injuries;CD4 Positive T Lymphocytes;Cells;checkpoint therapy;Clinical Research;Clinical Trials;Collaborations;Communication;CSF1R gene;CTLA4 blockade;CTLA4 gene;Cues;Data;Dependence;Development;Diffuse astrocytoma;effector T cell;Environment;Exposure to;Failure;genetic approach;Genetic Transcription;Glioblastoma;Glioma;Human;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune system;Immune Targeting;Immunosuppression;Immunotherapy;Infiltration;Inflammatory Infiltrate;Inflammatory Response;innovation;insight;Interdisciplinary Study;Intervention;Ligands;Long-Term Care;Macrophage;Malignant neoplasm of brain;Malignant Neoplasms;Mentorship;Methods;Microglia;Modeling;Molecular;mouse genetics;mouse model;Mus;Myeloid-derived suppressor cells;Natural Immunity;Nature;Neuroglia;neuroinflammation;novel;novel therapeutics;older patient;Other Genetics;Pathway interactions;patient engagement;Patients;Peripheral;Phagocytes;Phagocytosis;Phase II Clinical Trials;Physicians;polarized cell;Population;preclinical study;programmed cell death protein 1;programs;receptor;Receptor Protein-Tyrosine Kinases;recruit;Recurrence;Regulation;Regulatory T-Lymphocyte;Repression;Research;response;Role;Scientist;Shapes;Signal Pathway;Signal Transduction;skills;Source;standard of care;T cell infiltration;T-Lymphocyte;targeted treatment;Techniques;Th1 Cells;Therapeutic;Tissue Preservation;Training;transcriptomics;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor Subtype;Work

PROJECT_TITLE: Elucidating the distinct roles of T cell-polarized microglia in glioblastoma suppression and progression


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: WORCESTER

ORG_DEPT: GENETICS

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE We currently lack the ability to predict how cancer cells will respond to transcriptional inhibitors—a drug class of major clinical and pre-clinical interest. This proposal aims to characterize an unexpected mechanism by which transcriptional inhibition induces cell death. Rational drug design and patient selection depends on comprehensively understanding how transcriptional inhibitors activate regulated cell death.

PI_NAMEs: HARPER, NICHOLAS WADE (contact)

PROGRAM_OFFICER_NAME: ODEH, HANA M

PROJECT_TERMS: Accidents;Alternative Splicing;Apoptosis;Apoptotic;Bcl-2 Homology Domain;BCL2 gene;Binding;cancer cell;Cancerous;Candidate Disease Gene;Cell Death;Cell Death Induction;cell growth;cell killing;Cell Nucleus;Cell Physiology;cell type;Cells;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Consensus;CRISPR screen;Cytoplasm;Data;Death Rate;design;DNA Polymerase II;Drug Design;drug mechanism;Experimental Genetics;experimental study;Family member;Gene Expression;Genes;genetic regulatory protein;Genetic Transcription;genome-wide;Goals;Immunoprecipitation;improved;inhibitor;inhibitor therapy;insight;interest;Knock-out;Knowledge;live cell imaging;live cell microscopy;Measures;Messenger RNA;Methods;Mitochondria;Modeling;mRNA Expression;mRNA Precursor;Normal Cell;novel;novel drug combination;Nuclear;Nuclear Export;Nuclear Protein;Patient Selection;Patients;Pharmaceutical Preparations;Phenotype;pre-clinical;Process;Production;Protein Isoforms;Proteins;Regulation;Regulator Genes;Resistance;response;RNA;RNA immunoprecipitation sequencing;RNA Splicing;RNA-Binding Proteins;Role;Series;Signal Transduction;Testing;Time;Toxic effect;Transcript;treatment strategy;Work

PROJECT_TITLE: Mechanism of cell lethality following loss of gene expression.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PHARMACY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Patient Safety;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative The proposed R01, Improving Medication Adherence with Pharmacist and Community Health Worker Team (IMPaCT) to Reduce Disparities in Hypertension, will test the effectiveness of an innovative, culturally-tailored, coordinated care intervention derived from previous research (RxHL Study, 1R01HL120907) and existing pilot medication therapy management program at the research site. Building on an ecosocial framework of chronic disease self-management, the IMPaCT intervention by pharmacist-community health worker team will identify and address individual, clinical, social-cultural and structural barriers to medication adherence among low- income minority patients with hypertension, polypharmacy use and nonadherence. To determine effectiveness, we will conduct a rigorous, intention-to-treat randomized controlled trial among African-American, Latino and Vietnamese patients at a community health center to create a practical solution to the adherence problem and provide a how-to framework for healthcare workforce to reduce health disparities in hypertension and prevent cardiovascular risks among the vulnerable population.

PI_NAMEs: LEE, JEANNIE KIM (contact);SHAW, SUSAN J

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: accountable care organization;Address;Adherence;adherence rate;adverse outcome;African American;Automobile Driving;Belief;Blood Pressure;blood pressure control;Body mass index;burden of chronic illness;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;care coordination;care providers;Caring;caucasian American;Cessation of life;Chronic Disease;Clinical;Clinical Pharmacists;clinical practice;Communities;Community Health Aides;comorbidity;cost;culturally appropriate intervention;Data Collection;Death Rate;design;Diagnosis;Disparity;disparity reduction;Distal;Dose;Education;Effectiveness;effectiveness evaluation;effectiveness testing;Electronic Health Record;ethnic disparity;ethnic minority;Ethnic Population;experience;Face;food insecurity;Fright;Glycosylated hemoglobin A;Health;Health behavior;Health Insurance;health literacy;Health Services Accessibility;Healthcare;Heart Diseases;high risk;high risk population;Hypertension;Immigrant;improved;Individual;innovation;Insurance Coverage;Intention;Intervention;Kidney Diseases;Latino;Linguistics;low health literacy;Low income;Low Income Population;Low-Density Lipoproteins;mathematical ability;Measures;medication compliance;Medication Management;Medicine;member;minority patient;Modeling;neglect;Neighborhood Health Center;Outcome;Participant;patient navigator;patient oriented;Patient Self-Report;Patients;Pharmaceutical Preparations;Pharmacists;pill;Play;Polypharmacy;Population Heterogeneity;post intervention;Poverty;premature;prevent;Primary Care;primary care provider;programs;Qualifying;racial disparity;racial minority;racial minority population;racial population;Randomized;Randomized, Controlled Trials;Reduce health disparities;Regimen;Reporting;Research;Research Personnel;Research Project Grants;Resources;response;Risk Factors;Role;Self Management;Services;Site;skills;social;social culture;Social Environment;Social support;Stroke;Surveys;theories;Transportation;Vietnamese;Vulnerable Populations;Waiting Lists;Work

PROJECT_TITLE: Pharmacist-CHW Team to Improve Medication Adherence and Reduce Hypertension Disparities

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Chromosomally unstable cancer cells frequently harbor cytoplasmic DNA that activates a cell-intrinsic innate immune response. We currently do not understand whether these cytoplasmic DNAs are capable of eliciting non-cell autonomous effects to surrounding cells in the tumor microenvironment. The proposed research seeks to elucidate whether and how fragmented chromosomes entrapped in the cytoplasm can undergo lateral transfer between cells in a shared environment, which will advance our understanding of cell-to-cell interactions in the tumor microenvironment.

PI_NAMEs: MAURAIS, ELIZABETH  (contact)

PROJECT_TERMS: acquired drug resistance;Adopted;Alleles;Bacteria;cancer cell;cancer genome;Cell Communication;Cell division;Cell Nucleus;cell type;Cells;chromosome missegregation;Chromosome Segregation;Chromosomes;chromothripsis;Coculture Techniques;Complex;Cytogenetics;Cytoplasm;Data;Defect;Development;digital;DNA;DNA Damage;DNA Sequence;DNA Sequence Rearrangement;DNA sequencing;Drug resistance;Ecosystem;Environment;Event;Exhibits;Exposure to;extracellular;Female;Fluorescence;Fluorescent in Situ Hybridization;Frequencies;Genetic;Genetic Materials;Genetic Polymorphism;Genome;genome sequencing;Genomic Instability;Genomics;Goals;Human;Immune response;Innate Immune Response;Knowledge;Label;Lateral;Lipids;live cell imaging;male;Malignant Neoplasms;Mammalian Cell;Maps;Measures;Mediating;Messenger RNA;micronucleus;MicroRNAs;Mitochondria;Mitosis;Mitotic;Modeling;Monitor;Mutate;Mutation;next generation;Nuclear Envelope;Nuclear Structure;Nucleic Acids;Oncogenes;Organelles;Pathway interactions;Phenotype;Predisposition;Process;Proteins;Reporter;Research;Resistance;Resolution;response;Role;sensor;Signal Transduction;Single Nucleotide Polymorphism;Site;Stimulator of Interferon Genes;Structure;System;Testing;trafficking;tumor microenvironment;uptake;Visualization;whole genome;Y Chromosome

PROJECT_TITLE: Non-cell autonomous consequences of cytoplasmic DNA

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: ROCHESTER

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Project Narrative Timbre, or the quality of a sound, is a critical component of speech, music, and sound source identification, yet how timbre is encoded by the central nervous system is not understood. This proposal will investigate how suprathreshold synthetic and natural timbre sounds are encoded in neurons of the auditory midbrain, while also improving a computational model to be used for these and other complex sounds. This research is relevant to public health as cochlear implants and hearing aids distort timbre; our results will inform novel signal-processing strategies to benefit users of cochlear implants and hearing aids.

PI_NAMEs: FRITZINGER, JOHANNA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Acoustic Nerve;Area;Auditory;Auditory system;awake;Brain Stem;Cells;Central Nervous System;Characteristics;Cochlear Implants;Code;Communication;Complex;Comprehension;Computer Models;Contralateral;Data;design;experimental study;extracellular;Fiber;Frequencies;Hearing Aids;improved;Inferior Colliculus;Inner Hair Cells;insight;instrument;Lead;Midbrain structure;Modeling;Music;Nerve Fibers;neural;neural model;Neurons;Noise;novel;novel strategies;Oryctolagus cuniculus;Perception;Peripheral;Phase;physiologic model;Physiological;Play;Population;Psychophysics;Public Health;Research;Research Project Grants;response;Shapes;Signal Transduction;sound;Source;Speech;Stimulus;Study models;Testing;Thalamic structure;training opportunity;Update;Variant;Work

PROJECT_TITLE: Physiological and Computational-Modeling Studies of Timbre Encoding in the Inferior Colliculus


NIH_SPENDING_CATS: Aging;Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Hearing Loss;Neurodegenerative;Neurosciences;Prevention;Rehabilitation

ORG_CITY: CHARLESTON

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE Despite the well-described impacts of age-related hearing loss (ARHL) on general and hearing-specific health, little information exists on benefits of hearing aid use for these outcomes, or on whether earlier intervention improves treatment results. This epidemiological study conducted in a sample of the general population will assess benefits of hearing aid use on psychosocial well-being, communication, and cognitive outcomes that capture general and hearing-specific health, and will determine the extent to which earlier intervention for ARHL is a determinant of hearing aid benefit. Findings from this work will provide a scientific framework for clinical and public health recommendations related to the optimal timing of hearing aid interventions.

PI_NAMEs: DILLARD, LAUREN KAY (contact)

PROJECT_TERMS: Address;Adult;Age;age effect;Aging;Apple;Audiology;career;Chronic;Clinical;clinical practice;Clinical Trials;Cognition;Cognitive;cognitive function;Cohort Studies;Communication;Communities;dalton;Data;Development;Diagnosis;Early Intervention;Educational process of instructing;Engineering;Environment;Epidemiology;epidemiology study;evidence base;follow-up;frailty;Funding;Future;General Population;Goals;Health;Health Personnel;Health Promotion;Hearing;Hearing Aids;hearing impairment;help-seeking behavior;human old age (65+);improved;Individual;Intervention;Knowledge;Longitudinal cohort study;Measures;Medical;Medicine;Mentors;Methods;National Institute on Deafness and Other Communication Disorders;Neuronal Plasticity;Outcome;Participant;population based;Population Study;Presbycusis;prospective;psychosocial;psychosocial wellbeing;Public Health;public health priorities;public health research;Randomized, Controlled Trials;Recommendation;Research;Research Personnel;Research Project Grants;Risk;Sampling;screening;Secondary Prevention;Severities;South Carolina;Speech;Strategic Planning;Surveys;tertiary prevention;Testing;Time;Training;United States National Academy of Sciences;United States National Institutes of Health;Universities;uptake;Work

PROJECT_TITLE: Early intervention as a determinant of hearing aid benefit for age-related hearing loss: Results from longitudinal cohort studies


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE A disproportionate burden of cumulative lifetime trauma among African American (A.A.) people living with HIV may, directly and indirectly, contribute to poor retention in HIV care, poor viral suppression, and high morbidity and mortality in A.A. communities. The proposed study aims to understand the role of trauma on health disparities seen in the HIV health continuum, specifically, retention in HIV care and durable viral suppression among A.A. men and women living with HIV. The findings of the proposed study will provide a deeper understanding of the long-term clinical implications of trauma on retention in HIV care and durable viral suppression among A.A. people living with HIV; these findings may also inform routine follow-up practices to reduce the trend in health inequities among A.A. people living with HIV.

PI_NAMEs: MONTILUS, MARY  (contact)

PROGRAM_OFFICER_NAME: WILLIS, LEIGH ANDREW

PROJECT_TERMS: Adult;African American;African American population;American;Ancillary Study;Black race;career;Caring;Child Sexual Abuse;Childhood;Chronic Disease;Clinical;Clinical Services;Communities;Complex;Continuity of Patient Care;Data;Data Analyses;Data Set;design;Disease Progression;Ethnic Origin;experience;Fellowship;follow-up;Foundations;Gender;General Population;Goals;Health;health disparity;health inequalities;health literacy;HIV;HIV diagnosis;HIV Seronegativity;HIV Seropositivity;improved;Individual;interpersonal trauma;intimate partner violence;Knowledge;Life;Long-Term Effects;Longitudinal Studies;medical appointment;men;Morbidity - disease rate;mortality;Outcome;parent project;Participant;Partner Abuse;Patients;Persons;physical abuse;physical assault;Population;prevent;Race;racial disparity;Research;Risk;Role;secondary analysis;sexual assault;sexual trauma;Testing;Time;transmission process;Trauma;treatment adherence;trend;Viral;Viral Load result;viral rebound;Woman

PROJECT_TITLE: Effects of trauma on retention in HIV care and durable viral suppression among African American men and women

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(86)]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Liver Disease;Organ Transplantation;Transplantation

ORG_CITY: LOS ANGELES

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE The shortage and poor quality of donor organs represent major limitations facing liver transplantation, the gold standard of care in patients with end-stage liver disease and those with tumors of hepatic origin. The goal of this project is to improve long-term liver transplant outcomes as well as “rejuvenating” suboptimal hepatic tissue, and promoting homeostasis without late fibrotic pathology. Our findings should facilitate innovative interventions to improve the quality/size of the current organ supply, an absolute imperative for the full realization of success for solid organ transplantation

PI_NAMEs: KUPIEC-WEGLINSKI, JERZY W (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Acute;Affect;Agonist;alternative treatment;Anti-Inflammatory Agents;Antiinflammatory Effect;Attenuated;Autophagocytosis;Binding;Biological;Cell Physiology;Cells;Chronic;chronic liver disease;Clinical;Cytoprotection;editorial;end stage liver disease;Epidemic;experimental study;Formulation;Genes;Glucocorticoid Receptor;glucocorticoid-induced orphan receptor;Glucocorticoids;Goals;Heart failure;Hepatic;Hepatic Tissue;Hepatocyte;Hepatology;Homeostasis;Human;Immune;immunoregulation;improved;Inflammation;Inflammatory;innovation;insight;Intervention;Ischemia;Knock-in Mouse;Link;Liver;Liver Fibrosis;liver ischemia;Liver neoplasms;liver transplantation;Macrophage;Macrophage Activation;mimetics;Molecular;Mus;natural hypothermia;neural;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;Organ;Organ Donor;Organ Transplantation;Outcome;Pathology;Pathway interactions;Patients;peptide hormone;Perfusion;pharmacologic;Phase;Phase III Clinical Trials;Phenotype;Pilot Projects;preservation;prevent;Primary carcinoma of the liver cells;Property;Publishing;receptor;Receptor Signaling;Recombinants;regeneration function;Regulation;Rejuvenation;Relaxin;relaxin receptor;Reperfusion Injury;Resistance;Resolution;response;Role;Severities;side effect;Signal Transduction;SIRT1 gene;small molecule;Solid;Somatomedins;standard of care;Stress;success;System;T-Lymphocyte;Testing;tissue injury;Tissues;tool;transplant model;Transplant Recipients;Transplantation

PROJECT_TITLE: THE RELAXIN RECEPTOR GR/RXFP1 SIGNALING IN LIVER TRANSPLANT ISCHEMIA-REPERFUSION INJURY AND THE INFLAMMATION RESOLUTION

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BUFFALO

ORG_NAME: ROSWELL PARK CANCER INSTITUTE CORP

PHR: Project Narrative Innate lymphoid cells (ILCs) are highly plastic cells that can exert both enhancing and regulatory activity in tumor microenvironment depending on the type of signals they receive. Our hypothesis is that the suppressor functions of ILC2s are enhanced by stress through β2 adrenergic signaling and thus contributes to the known tumor promoting effects of stress. The work proposed here will investigate how adrenergic stress affects ILC2 plasticity and immune-inhibitory functionality in the tumor site with the long-term intent of improving outcomes of immunotherapy in patients.

PI_NAMEs: CHOI, JEE EUN  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adrenergic Agents;Adrenergic beta-Agonists;Adrenergic Receptor;adrenergic stress;Affect;anti-tumor immune response;Antitumor Response;Ants;beta-2 Adrenergic Receptors;Binding;Breast Cancer Model;breast cancer progression;Cancer Biology;Cancer Patient;Cancer Prognosis;catalyst;Cell Differentiation process;Cells;Chronic stress;Common Lymphoid Progenitor;comparison control;conditional knockout;cytotoxic;Cytotoxic T-Lymphocytes;Data;Development;Ensure;Enzyme-Linked Immunosorbent Assay;EO771;Event;Exhibits;experience;Fellowship;Flow Cytometry;GATA3 gene;Goals;Helper-Inducer T-Lymphocyte;Immune;Immune response;Immunity;Immunosuppression;Immunotherapy;improved;improved outcome;In Vitro;in vivo Model;Infiltration;Isoproterenol;Knock-out;Knockout Mice;Knowledge;Literature;Lymphoid Cell;Lymphoid Tissue;Malignant Neoplasms;Mediating;Melanoma;Methodology;Methods;Molecular;Moon;Mus;Myeloid-derived suppressor cells;Natural Killer Cells;Nature;Nerve;nerve supply;Norepinephrine;novel;Pathway Analysis;Pathway interactions;patient prognosis;Patients;Phenotype;Physicians;Play;Population;Pre-Clinical Model;prevent;Proteins;Publishing;Receptor Signaling;Regulation;response;Role;Scientist;Signal Transduction;single-cell RNA sequencing;Site;skills;Sorting;stem cell differentiation;Stress;Surface;T cell differentiation;T-Lymphocyte;Techniques;Testing;Training;Treatment outcome;tumor;tumor growth;Tumor Immunity;tumor microenvironment;tumor progression;Tumor Promotion;Tumor Volume;tumor-immune system interactions;Work

PROJECT_TITLE: Understanding the role of β2AR-signaling on ILC2 differentiation/plasticity and its implications in cancer progression


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Epithelial-mesenchymal transition (EMT) is a normal cellular program involved in development and wound healing that occurs aberrantly in carcinomas to promote metastasis and chemotherapy resistance. Within cell populations and tumors, EMT occurs with a high degree of heterogeneity, with some cells undergoing the transition and others remaining in an epithelial state. This project will develop integrated experimental and computational methods for quantifying the degree to which EMT heterogeneity is regulated transcriptionally or via biochemical signaling processes in pancreatic ductal adenocarcinoma (PDAC), with anticipated results having important implications for developing novel combination therapies for PDAC.

PI_NAMEs: BARBEAU, MICHELLE C (contact)

PROJECT_TERMS: Agonist;Antibodies;Bar Codes;Biochemical;Candidate Disease Gene;Carcinoma;Cell Line;Cell Lineage;cell population study;cell transformation;Cells;Characteristics;Chemoresistance;chemotherapy;Combined Modality Therapy;Computer Models;Computing Methodologies;cytokine;Data;Data Science;Data Set;design;Development;Developmental Process;differential expression;Disease Progression;epithelial to mesenchymal transition;Epithelium;Exhibits;experimental study;fluorescence imaging;Gene Expression Profile;Genetic;Genetic Transcription;Growth Factor;Heterogeneity;Human;human imaging;Hypoxia;Image;Immunofluorescence Immunologic;Indirect Immunofluorescence;Individual;Infection;information model;Information Theory;insight;interest;knock-down;Lead;Libraries;Maintenance;Malignant Neoplasms;Measures;Mediating;Mesenchymal;Methods;Modeling;Molecular;Neoplasm Metastasis;novel;overexpression;Oxygen;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Pathway interactions;Phenotype;Phosphoproteins;Phosphotransferases;Population;predictive modeling;prevent;Process;programs;Protocols documentation;Regulation;Resistance;response;Signal Pathway;Signal Transduction;single cell analysis;single-cell RNA sequencing;Small Interfering RNA;small molecule inhibitor;Sorting;Systems Biology;Testing;Transcript;transcription factor;transcriptome sequencing;transcriptomic profiling;Treatment Factor;tumor;Uncertainty;Variant;Work;wound healing

PROJECT_TITLE: Assessing the Transcriptional and Signaling Basis of Heterogeneity in the Epithelial-Mesenchymal Transition in Pancreatic Ductal Adenocarcinoma


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because studying new chemical and molecular approaches to inhibition of high-risk childhood neuroblastoma may result in novel approaches to treatment of this devastating childhood cancer, as well as other EP300-dependent cancers. The strategy described here, in which existing and newly-generated agents targeting the known neuroblastoma dependency EP300 are assessed alone and in combination with conventional chemotherapy agents is highly relevant to the NCI mission of developing novel therapeutic approaches to advance scientific knowledge, improve survival outcomes and reduce the toxicities of cancer therapy.

PI_NAMEs: DURBIN, ADAM DAVID (contact)

PROJECT_TERMS: Acetylation;Address;Adult;Animal Experiments;Animal Model;Apoptosis;assay development;Binding;Binding Proteins;Biological Assay;biological heterogeneity;Biology;cancer therapy;Cardiac;career;career development;Cell Death;cell growth;cell killing;Cell Line;Cell Survival;Cells;Chemicals;chemotherapeutic agent;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;Childhood Solid Neoplasm;Clinical;clinical heterogeneity;Collaborations;combinatorial;Compensation;Coupled;CREBBP gene;CRISPR/Cas technology;Dana-Farber Cancer Institute;Data;Dependence;design;Development;Disease;Dropout;drug discovery;Drug Targeting;Enhancers;Environment;Enzymes;EP300 gene;epigenomics;exome;experience;experimental study;Foundations;Frequencies;Gene Expression;Generations;Genes;Genetic Transcription;Goals;Grant;Growth;high risk;histone acetyltransferase;improved;In Vitro;in vitro Assay;in vivo;in vivo Model;Infertility;innovation;Institution;instructor;Investigation;Investigational Therapies;Knock-in;Knowledge;Laboratories;Lead;Leadership;Learning;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;member;Mentors;Methods;Mission;Modeling;Molecular;mouse model;mRNA Expression;Mutate;Mutation;MYC Family Protein;neoplastic cell;Neuroblastoma;neuroblastoma cell;Normal Cell;Normal tissue morphology;novel;novel strategies;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;paralogous gene;patient derived xenograft model;Patients;Pediatrics;Pharmaceutical Preparations;Preparation;Production;Protac;Proteins;Public Health;Qi;Reporter Genes;Research;Risk;Role;Scientific Advances and Accomplishments;Scientist;Second Primary Cancers;skills;small molecule;Solid Neoplasm;Specificity;Surveys;survival outcome;Survivors;targeted agent;targeted treatment;Technology;Testing;Therapeutic;therapeutic target;Time;tool;Toxic effect;Training;training opportunity;transcription factor;Treatment-related toxicity;tumor;tumor growth;Western Blotting;Work;Writing

PROJECT_TITLE: Targeting EP300, a selective dependency in neuroblastoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Narrative When cells are stressed they can adapt and try to survive, or they can instead undergo cell death if the stress is too severe. Cancer cells tip this balance by finding ways to survive when normal cells might typically die. Our research has contributed significant new knowledge by uncovering mechanisms of cell death and new cellular adaptations that promote cell survival, uncovering vulnerabilities that can be targeted for cancer therapy.

PI_NAMEs: OVERHOLTZER, MICHAEL H. (contact)

PROGRAM_OFFICER_NAME: LUO, RUIBAI

PROJECT_TERMS: Area;Biological;biological adaptation to stress;cancer cell;cancer therapy;Cell Death;Cell Survival;Cells;Cellular Stress;Equilibrium;Image;Knowledge;Lysosomes;Malignant Neoplasms;Methods;Normal Cell;Nutrient;Population;Population Control;Population Dynamics;programs;Research;response;Starvation;Stress;targeted cancer therapy;treatment response;tumor microenvironment

PROJECT_TITLE: Regulated cell death and responses to starvation in cancer


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: MADISON

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Significant concern exists about the COVID-19 pandemic causing increased antibiotic prescribing in hospitals and accelerating the public health threat of bacterial resistance. In this project, we will measure the impact of COVID-19 on overall and condition specific antibiotic prescribing and bacterial resistance patterns using data from a diverse, nationally representative group of over 350 U.S. hospitals. We will then conduct interviews with healthcare professionals at hospitals with varying alterations in antibiotic prescribing during the pandemic to identify effective strategies for inclusion in a resilient antibiotic stewardship implementation toolkit.

PI_NAMEs: PULIA, MICHAEL SANTINO (contact)

PROGRAM_OFFICER_NAME: LIN, LEYI

PROJECT_TITLE: Characterizing the ImPact of COVID-19 on Antibiotic PreScribing in AcutE Care and IDentifying Resilient Stewardship Strategies (POISED)

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health;Women's Health Research

ORG_CITY: EAST LANSING

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative The novel and theory-driven 16-week “Guys/Girls Opt for Activities for Life” (GOAL) school- and home-based intervention addresses the high overweight and obesity prevalence among U.S. adolescents and the underrepresentation of those who are underserved in prevention research. To address these vital public health priorities, a rigorous group RCT will be used to evaluate the efficacy of the GOAL intervention in improving healthy eating and physical activity and perceptions related to both behaviors, as well as anthropometric outcomes among urban, racially diverse, adolescents of low socioeconomic status. The intervention is expected to reduce cardiovascular disease risk factors among at-risk adolescents and contribute toward reducing health disparities, a major priority of the NIH and CDC Division of Adolescent and School Health.

PI_NAMEs: ROBBINS, LORRAINE BRENDA (contact)

PROGRAM_OFFICER_NAME: PRATT, CHARLOTTE A

PROJECT_TERMS: Accelerometer;Address;Adolescence;Adolescent;adolescent health;Aerobic;Age;aged;Base Pairing;Behavior;Behavioral;Body Composition;Body fat;Body mass index;boys;Cardiovascular Diseases;cardiovascular disorder risk;Characteristics;cohort;comparison control;cooking;Data;data submission;Diet;dietary;disparity reduction;Distal;Early Intervention;early onset;Eating Behavior;efficacy evaluation;empowerment;Enrollment;Evaluation;Event;evidence base;Exhibits;falls;Family;Female Adolescents;Fiber;fitness;Fostering;fruits and vegetables;girls;Goals;Group Meetings;Health;Healthy Eating;Home;Home environment;implementation facilitation;improved;indexing;Individual;Infrastructure;Institutional Review Boards;Intention;Intervention;Life;low socioeconomic status;Male Adolescents;Mediating;meetings;Metabolic syndrome;Minority;Modeling;moderate-to-vigorous physical activity;Monitor;Motivation;multi-component intervention;National Heart, Lung, and Blood Institute;novel;nutrition;Obesity;Obesity associated cardiovascular disease;obesity risk;obesogenic;Outcome;Overweight;Parents;Perception;Persons;Phase;phase II trial;Physical activity;Pilot Projects;post intervention;Prevalence;Prevention Research;primary outcome;Privatization;Procedures;programs;Protocols documentation;public health priorities;Quality of life;racial diversity;Randomized;randomized trial;Readiness;recruit;Reduce health disparities;Reporting;Research Training;Risk;Risk Factors;Running;Safety;Sampling;satisfaction;school environment;school health;Schools;Self Determination;Self Efficacy;seventh grade;skills;Social Environment;social networking website;Social support;Testing;theories;Training;Unhealthy Diet;United States National Institutes of Health;urban area;web site;Weight;Work

PROJECT_TITLE: Guys/Girls Opt for Activities for Life (GOAL) Trial


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: BERKELEY

ORG_NAME: UNIVERSITY OF CALIFORNIA BERKELEY

PHR: PROJECT NARRATIVE Extracellular vesicles (EVs) comprise a heterogeneous pool of membrane-bound compartments exported from cells, and EV-mediated intercellular propagation of microRNA-122 (miR-122) has been purported to promote breast cancer metastasis in vivo. Concurrent with this line of experimental evidence, we have demonstrated, both in cells and a cell-free reaction, that the Lupus La antigen (La) mediates selective enrichment of miR-122 into a high-density exosome subpopulation of EVs derived from a metastatic breast cancer cell line, however, the mechanism underpinning this selective sorting event remains unclear. This proposal will elucidate the molecular mechanism by which the La:miR-122 ribonucleoprotein complex is selectively sorted into breast cancer-derived exosomes, and by extension, identify putative therapeutic targets for metastatic breast cancer and inform efforts to engineer exosomes into effective vehicles for therapeutic drug and nucleic acid delivery.

PI_NAMEs: NGO, JORDAN MATTHEW (contact)

PROJECT_TERMS: Antigens;Binding;Biochemical;Biogenesis;Biological Assay;Breast Cancer Cell;Breast Cancer cell line;breast cancer metastasis;Cancer Biology;candidate identification;Categories;Cell membrane;Cell secretion;Cells;cellular imaging;Classification;Complex;Cytoplasm;Data;delivery vehicle;density;diagnostic tool;Disease Progression;Dissection;efficacy evaluation;Electrophoretic Mobility Shift Assay;Endosomes;engineered exosomes;Eukaryotic Cell;Event;exosome;extracellular;Extracellular Space;extracellular vesicles;Fluorescence Microscopy;Foundations;Fractionation;Future;Genetic;glucose metabolism;Goals;Imaging Techniques;In Vitro;in vivo;insight;Integral Membrane Protein;interest;Jordan;Label;late endosome;Lipids;Lupus;Malignant Breast Neoplasm;Malignant Neoplasms;MDA MB 231;Mediating;Membrane;Metastatic breast cancer;MicroRNAs;microvesicles;Molecular;Multivesicular Body;National Research Service Awards;Neoplasm Metastasis;neoplastic cell;novel;nucleic acid delivery;Nucleic Acids;overexpression;Pathway interactions;Pharmaceutical Preparations;Play;Positioning Attribute;Process;Proteins;Proteomics;Reaction;receptor;Recombinants;reconstitution;Research;Research Personnel;Research Project Grants;Resolution;Ribonucleoproteins;RNA-Protein Interaction;Role;Small RNA;Sorting;stem cells;Tertiary Protein Structure;Therapeutic;therapeutic target;Training;Transfer RNA;tumor progression;Vesicle

PROJECT_TITLE: Mechanism of Lupus La:miR-122 ribonucleoprotein sorting into breast cancer-derived exosomes


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Prevention;Social Determinants of Health

ORG_CITY: Durban

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: KWAZULU-NATAL RESEARCH INSTITUTE TB-HIV

PHR: PROJECT NARRATIVE Hypertension is the risk factor responsible for the greatest reduction in quality-adjusted life years globally, and effective therapies that reduce blood pressure and its related mortality make it an ideal target for public health programs. However, sustained hypertension control on a population level has been a major challenge, particularly in low-resource settings. We will partner with the South African Department of Health to implement a combination of individual and clinic-based interventions to achieve sustained blood pressure control in a high-prevalence, low-resource region of rural South Africa. We will adopt an implementation science framework to consider acceptability, feasibility, effectiveness, and assess conditions for reproducibility and scalability, to inform best practices for implementation of hypertension control in LMICs, and to ensure our findings are directly relevant to academic and public health stakeholders implementing similar programs globally. !

PI_NAMEs: GAZIANO, THOMAS A;SIEDNER, MARK J (contact)

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: 18 year old;acceptability and feasibility;Achievement;Adopted;Adult;Africa South of the Sahara;Age;Blood Pressure;blood pressure control;blood pressure elevation;Blood Pressure Monitors;blood pressure reduction;care systems;Caring;Catchment Area;Cessation of life;Chronic Care;Clinic;Clinical;clinical care;Clinical Trials;Cluster randomized trial;Communities;Consolidated Framework for Implementation Research;cost;cost effective;cost effective intervention;cost effectiveness;Country;Data;Development;disability-adjusted life years;Discipline of Nursing;Disease;disorder control;effective therapy;Effectiveness;effectiveness evaluation;Employment;Ensure;Evidence based practice;Failure;Funding;global health;Goals;Health;health disparity;Health Personnel;Health Priorities;Health Professional;Health system;High Prevalence;Home;Home Blood Pressure Monitoring;Hour;Hypertension;hypertension control;hypertension treatment;hypertensive heart disease;implementation evaluation;implementation framework;implementation intervention;implementation outcomes;implementation science;improved;Individual;Infrastructure;innovation;Intervention;Interview;Investments;Knowledge;Literature;low and middle-income countries;Low income;male;Measures;Methods;Modeling;monitoring device;Morbidity - disease rate;mortality;multidisciplinary;Nurses;Patients;Penetration;Persons;Population;premature;Primary Care;Proctor framework;programs;Public Health;Public Sector;Quality of life;Quality-Adjusted Life Years;Randomized;Reduce health disparities;Reproducibility;Research Methodology;Resource-limited setting;Resources;response;Risk Factors;Rural;rural South Africa;screening;Self Efficacy;sex;Site;South Africa;South African;Stroke;System;Training;Translating;Translations;treatment as usual;Vulnerable Populations;Work;years of life lost

PROJECT_TITLE: Implementation of a Combination Intervention for Sustainable Blood Pressure Control in Rural KwaZulu-Natal, South Africa (IMPACT-BP)

STUDY_SECTION: DIRH

STUDY_SECTION_NAME: Dissemination and Implementation Research in Health Study Section[DIRH]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative  Autism spectrum disorder (ASD) affects 1 in 44 children, but the underlying mechanisms that lead to ASD are poorly understood. This project studies the role of CHD8, a high-confidence autism risk gene identified in patients with ASD, in shaping key biological processes in early vertebrate brain development. Together, this work will advance our understanding of this important gene and shed light on the basic mechanisms underlying neurodevelopment in ASD.

PI_NAMEs: FITZPATRICK, SARAH E. (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Address;Affect;Affinity Chromatography;Autism Diagnosis;autism spectrum disorder;autism symptoms;Behavior;Biological Models;Biological Process;Biological Testing;Brain;brain abnormalities;Cell Cycle;Cell Cycle Progression;Cell Cycle Proteins;Cell Cycle Regulation;Cell Differentiation process;Cell Proliferation;Cell Separation;cell type;Cells;Child;Chromatin Remodeling Factor;clinical phenotype;Communication;communication behavior;Confocal Microscopy;Coupled;Data;de novo mutation;Development;Diagnosis;Disease;DNA-Binding Proteins;Embryo;Equilibrium;Fertilization;Flow Cytometry;Fluorescence;Foundations;Frameshift Mutation;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Genetic Transcription;Goals;Growth;helicase;Hour;Image;Impairment;improved;in vitro Model;in vivo;individuals with autism spectrum disorder;insight;Larva;Lead;Learning;loss of function mutation;Mentors;migration;Mitosis;Modeling;Molecular;Mus;mutant;Mutation;nerve stem cell;neural;neurobiological mechanism;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuromechanism;Neurons;Nonverbal Communication;Orthologous Gene;Pathway interactions;Patients;Pharmacological Treatment;Phase;Phase Transition;Physicians;Ploidies;postmitotic;Prevalence;Process;progenitor;Proliferating;Protein Biosynthesis;protein expression;Proteins;repetitive behavior;Reporter;Research;Ribosomes;risk variant;Role;Scientist;Shapes;single-cell RNA sequencing;social skills;stem cell proliferation;Synapses;synaptogenesis;System;Time;Training;Transcript;transcriptome;Transgenic Organisms;Translating;translating ribosome affinity purification and RNA-sequencing;Translation Initiation;Translations;translatome;Ubiquitination;United States;verbal;Visualization;Work;Zebrafish

PROJECT_TITLE: The Role of the ASD Risk Gene CHD8 in Neural Development


ADMINISTERING_IC: NS

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE (OVERALL) The overall goal of the CWOW is to use multi-omics and functional genomics CRISPR screens to understand the molecular and cellular differences in gene expression and cellular function as a consequence of the H1/H2 haplotype inversion, and the resulting effects on risk for sporadic and familial tauopathies, leading to novel therapeutic targets for treatment of tauopathies.

PI_NAMEs: GESCHWIND, DANIEL H;GOATE, ALISON M (contact);KAMPMANN, MARTIN

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: 17q21;3-Dimensional;African;African ancestry;Alleles;ATAC-seq;Automobile Driving;Biological;Brain;brain tissue;causal variant;Cell Communication;Cell Culture Techniques;Cell Physiology;cell type;Cells;Chromatin Structure;Chromosome inversion;Chromosomes;Collaborations;Communication;Communities;Complex;CRISPR interference;CRISPR screen;Data;data integration;data sharing;Dementia;Disease;disease model;disorder risk;distributed data;drug discovery;Enhancers;European;European ancestry;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;functional genomics;Future;Gene Abnormality;Gene Expression;Gene Expression Regulation;Gene Proteins;Genes;Genetic;genetic association;Genetic Transcription;Genomics;Genotype;Glutamates;Goals;Haplotypes;Human;human induced pluripotent stem cells;human tissue;In Vitro;in vivo;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Inherited;Lead;Measures;Mediating;meetings;Methods;Molecular;molecular modeling;Multiomic Data;multiple omics;Mutation;mutation carrier;Nerve Degeneration;Neuroglia;Neurons;new therapeutic target;Nongovernmental Organizations;Nuclear;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Post-Translational Protein Processing;programs;Progressive Supranuclear Palsy;Proteins;Proteomics;Public Domains;rare variant;Recording of previous events;Regulatory Element;repository;Research;Research Personnel;Resources;Risk;RNA Splicing;Role;single nucleus RNA-sequencing;Site;Stress;System;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;therapeutic development;tool;United States National Institutes of Health;Validation;Variant;Visualization;web site;Work

PROJECT_TITLE: Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Neurodegenerative;Neurosciences

PI_NAMEs: GOATE, ALISON M (contact)

PROJECT_TERMS: 17q21;Advisory Committees;Articulation;Awareness;Benchmarking;brain tissue;Budgets;Chromosomes;Collaborations;Common Data Element;Communication;Communities;Data;data exchange;data sharing;Dementia;design;Development;Effectiveness;Ensure;Evaluation;Event;Feedback;Funding;Genetic;Geography;Goals;Government;Growth;Haplotypes;Human Resources;Induced pluripotent stem cell derived neurons;innovation;Institution;interdisciplinary approach;Interdisciplinary Study;International;Knowledge;Leadership;Los Angeles;Maintenance;Measures;Medial;medical schools;meetings;Mission;Molecular;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurobiology;Neuroglia;New York;outreach;Patient advocacy;Process;programs;Proteomics;Regulation;Research;Research Personnel;Resource Sharing;Resources;Risk;Role;San Francisco;Science;Site;Structure;tau Proteins;Tauopathies;Technology;timeline;transcriptomics;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Core A: Administrative


ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE Reduced interferon (IFN) signaling is major way tumor cells evade the immune system. Mitochondria are central players in cell metabolism, but their role in regulating anti-tumor immune responses is less well understood. This project examines the link between mitochondria and IFN signaling, which may provide new ways to target tumor metabolism to bolster anti-tumor immune responses and the effectiveness of immunotherapy.

PI_NAMEs: JOHNSON, MELISSA  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Acute;Adaptive Immune System;Affect;anti-tumor immune response;Antigen Presentation Pathway;Antioxidants;Antitumor Response;ATAC-seq;Autoimmune;cancer cell;cancer immunotherapy;cancer therapy;CD8-Positive T-Lymphocytes;cell type;Cellular Metabolic Process;ChIP-seq;Chromatin;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;Data;Dependence;desensitization;Development;Down-Regulation;Effectiveness;Electron Transport;Event;Expression Profiling;fatty acid metabolism;fatty acid oxidation;Fatty Acids;Fluorescence Microscopy;Heart;Immune Evasion;Immune response;Immune system;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;Innate Immune System;insight;Interferon alpha;Interferon Type I;Interferon Type II;Interferon-beta;Interferons;Knock-out;Link;Major Histocompatibility Complex;Malignant Neoplasms;Mediating;Melanoma;Melanoma Cell;Membrane Potentials;Metabolic;Metabolism;metabolomics;Mitochondria;mitochondrial membrane;mitochondrial metabolism;Mus;neoplastic cell;novel;Oxidative Phosphorylation;Pathway interactions;pharmacologic;Phenotype;Phosphorylation;Play;Process;Production;programmed cell death ligand 1;Proteins;Reaction;Reactive Oxygen Species;Regulation;response;RNA;Role;Screening Result;Signal Pathway;Signal Transduction;Skin Cancer;Surface;Testing;Therapeutic;therapy development;transcription factor;Transcriptional Activation;transcriptomics;tumor;Tumor Immunity;tumor metabolism;tumor microenvironment;tumor progression;tumor-immune system interactions;Up-Regulation;Western Blotting;Work

PROJECT_TITLE: Mitochondrial Regulation of Interferon Response in Melanoma


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE  Currently, there are few options for treating diffuse cancers, particularly those that arise in sensitive tissues (i.e., not amenable to resection), in tissues in which drug diffusion is limited, or in patients for whom typical interventions incur unacceptable sequelae (e.g., pediatric patients). Using as basis one of the most aggressive forms of pediatric brain tumor, Diffuse Intrinsic Pontine Glioma (DIPG), we propose the use of safe electrical fields to move and/or consolidate DIPG cells – electrotaxis – and thus provide a strategy to for making diffuse cancers amenable to surgical removal and/or chemo/radio therapeutic treatment.

PI_NAMEs: MOKARRAM-DORRI, NASSIR  (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Address;Adult;Brain;Brain Neoplasms;brain tissue;Breathing;Butterflies;cancer cell;cancer therapy;Cancerous;Cell Differentiation process;cell motility;Cells;Childhood Brain Neoplasm;Computer Simulation;Computing Methodologies;Cues;curative treatments;Data;Deep Brain Stimulation;Deglutition;design;Development;Diffuse;Diffuse intrinsic pontine glioma;Diffusion;Drug Targeting;electric field;Electrodes;Embryonic Development;Environment;Excision;Exercise;Fatality rate;Glioma;glioma cell line;Growth;Implanted Electrodes;improved;In Vitro;in vivo;innovation;insight;Intervention;Invaded;Knowledge;Location;Malignant neoplasm of brain;Malignant Neoplasms;Mastication;Messenger RNA;Methods;minimally invasive;Modeling;Molecular;Mus;neoplastic cell;Neurons;novel strategies;Operative Surgical Procedures;Outcome;palliative;patient population;Patients;Pattern;pediatric patients;Pharmaceutical Preparations;pharmacologic;Physiologic pulse;Pontine structure;Population;Positioning Attribute;prevent;Radio;rational design;Research;Resectable;response;Safety;Shapes;Site;standard of care;Therapeutic;Therapeutic Effect;Time;Tissues;transcriptomics;tumor;tumor microenvironment;Volition;voltage;wound healing;Xenograft Model

PROJECT_TITLE: Tumor 'tractor beam' for diffuse cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-J(70)R]


ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: Project Narrative Asymptomatic colonization (i.e., carriage) with carbapenem-resistant Enterobacterales (CRE), a type of highly drug-resistant bacteria, poses urgent challenges in U.S. hospitals: undetected colonized patients can transmit CRE to other patients, and colonized patients themselves are at a significantly higher risk of developing CRE infections. Because widescale screening for CRE colonization remains impractical for most U.S. hospitals, hospitals miss critical opportunities to identify patients at high risk of CRE colonization and infection early, when it is still possible to prevent deleterious patient outcomes. We propose to leverage state-of-the-art machine learning and natural language processing (NLP) techniques on electronic health records (EHRs) to improve identification of CRE-colonized and infected patients by: (a) developing and validating natural language processing classifiers to detect established and new CRE risk factors from free-text, narrative EHR data; (b) using NLP-derived variables with EHR structured data to predict CRE colonization at admission; and (c) developing machine learning-based models to predict which CRE-colonized patients will progress to infection during the hospital stay, in order to guide precision medicine-based approaches for interventions.

PI_NAMEs: GOODMAN, KATHERINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Using natural language processing and machine learning to identify patients at high risk of potentially preventable carbapenem-resistant Enterobacterales (CRE) infection

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases

PI_NAMEs: SWANEY, DANIELLE L (contact)

PROJECT_TERMS: 17q21;Affect;Bioinformatics;Biological;Biological Assay;brain cell;cell type;Cells;Chromatin Structure;Chromosomes;Communities;cost efficient;Data;data integration;Data Set;Detection;Development;Disease;Exhibits;experimental study;Frontotemporal Dementia;Gene Expression;Gene Expression Regulation;Genes;Genetic;Genetic Complementation Test;Genomics;Haplotypes;human tissue;innovative technologies;insight;interest;Maps;Mass Spectrum Analysis;Measures;Mediating;member;Molecular;Molecular Analysis;mutant;Mutation;Nerve Degeneration;Nervous System Disorder;novel;Pathway interactions;Phosphorylation;Phosphorylation Site;Population;Progressive Supranuclear Palsy;Property;Protein Analysis;Proteins;Proteome;Proteomics;Protocols documentation;Reproducibility;Research;Research Project Grants;Resources;Risk;RNA Splicing;Sampling;Signal Transduction;success;tau Proteins;Tauopathies;Technology;transcriptomics;Validation;Variant;Work

PROJECT_TITLE: Core B: Proteomics


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: AUGUSTA

ORG_NAME: AUGUSTA UNIVERSITY

PHR: Loss of muscle and bone mass with age are underlying factors contributing to falls and fractures in the elderly, and these fractures are very costly in terms of both financial burden and quality of life. A critical barrier to progress in correcting the problem of muscle and bone loss with aging is a poor understanding of the molecular and cellular mechanisms underlying age-related musculoskeletal dysfunction. Our goal is to address this problem by providing critical, new information on the molecular and cellular mechanisms that control these processes, and thereby improve scientific knowledge, technical capability, and eventually clinical practice.

PI_NAMEs: ISALES, CARLOS M. (contact)

PROGRAM_OFFICER_NAME: WILLIAMS, JOHN

PROJECT_TERMS: Address;Age;age related;age related changes;Age-Related Bone Loss;Aging;Aryl Hydrocarbon Receptor;Automobile Driving;Autophagocytosis;Award;Bioinformatics;Biological Assay;Biometry;Body Composition;bone;bone cell;Bone Density;bone imaging;bone loss;Bone Marrow Stem Cell;bone mass;Cell Aging;clinical practice;Collaborations;Core Facility;cost;cytokine;Data;detection of nutrient;Development;Dual-Energy X-Ray Absorptiometry;Elderly;Enzymes;falls;Financial Hardship;Fracture;frailty;Functional disorder;functional outcomes;Funding;Gait;Goals;healthspan;Hip Fractures;improved;In Vitro;in vivo;Individual;Inflammaging;Inflammatory;Intervention;Knock-out;Knowledge;Kynurenine;Measures;Mechanics;Mediating;Medical Students;Mentors;Mitochondria;Modeling;Molecular;Mus;Muscle;Muscle Cells;muscle form;muscle progenitor cell;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;Nuclear Receptors;Nutrient;older patient;Osteopenia;Osteoporosis;Pathway interactions;Phenotype;Play;prevent;Process;Productivity;programs;Puerto Rico;Quality of life;Receptor Activation;Receptor Cross-Talk;Receptor Signaling;receptor-mediated signaling;recruit;Research Personnel;Resources;sarcopenia;senescence;senescence associated secretory phenotype;Serum;sex;Sex Differences;skeletal;small molecule;stem cell function;stem cells;Testing;Tissues;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Work

PROJECT_TITLE: Kynurenine accumulation drives loss of muscle and bone function with aging


NIH_SPENDING_CATS: Aging

PHR: The purpose of the Administrative Biostatistics Core (Core A) is to provide administrative support, ensure project and core progress and continued synergy, disseminate scientific findings and provide biostatistical support. The Core will serve as the major data repository for analysis and as such represents a key component linking the individual projects and ensures data integrity. Moreover, the Core seeks to develop new investigators in the aging field by increasing participation of minority scientists.

PROJECT_TERMS: Address;Advisory Committees;Aging;Archives;Area;Award;Bioinformatics;Biometry;Biostatistics Core;bone;Certification;computerized data processing;Consultations;Data;Data Analyses;data integrity;data management;data modeling;data repository;Databases;deep sequencing;Effectiveness;Ensure;Experimental Designs;Faculty;Goals;Human Resources;Individual;Institutional Review Boards;interest;Kynurenine;Link;Manuscripts;medical schools;Medical Students;meetings;member;Mentors;Methods;Minority;Minority Participation;minority scientist;minority student;Modeling;Muscular Atrophy;next generation;Play;Policies;Preparation;programs;Publications;Puerto Rico;Quality Control;Research;Research Ethics;Research Personnel;Research Project Grants;Role;Rotation;Sample Size;Schedule;Scientist;Security;single-cell RNA sequencing;Site;Source;Statistical Data Interpretation;Structure;success;summer research;summer student;synergism;System;Techniques;Training;Training Programs;Universities;Validation;Work;Writing

PROJECT_TITLE: CORE A - Administrative Core


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;American Indian or Alaska Native;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Substance Misuse;Underage Drinking

ORG_CITY: PULLMAN

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Project Narrative The proposed research would be the first to examine the feasibility, engagement and implementation of a technology and behavioral economics enhanced Contingency Management study for alcohol misuse among American Indian young adults. The proposed research and training plan will provide the protected time for the candidate to acquire the knowledge and skills necessary to become an NIH-funded independent investigator with expertise in community engaged research, developing culturally grounded substance use disorder treatments for American Indian communities, behavioral economics, technology-delivered interventions and statistics.

PI_NAMEs: HIRCHAK, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: Abstinence;Achievement;Adopted;Adult;aged;alcohol abstinence;Alcohol abuse;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol use disorder;alcohol use initiation;Alcohols;American Indian community;American Indian Population;American Indians;Area;Behavior;Behavior Therapy;behavioral economics;binge drinking;Biological Markers;career;career development;Clinical Trials;college drinking;Communities;community advisory board;community based participatory research;community engaged research;contingency management;Data;Development;discounting;drinking;Drops;Focus Groups;Funding;Future;Glucuronides;Goals;Grant;Ground Substance;handheld mobile device;Health;Heavy Drinking;improved;Indian reservation;Individual;innovation;Intervention;Interview;Knowledge;Knowledge acquisition;Literature;Mediator;Mentors;Methods;Modification;Outcome;Phase;Pilot Projects;Population;Positive Reinforcements;Prevalence;Process;Protocols documentation;Provider;Psychological reinforcement;Randomized;Recovery;recruit;Research;Research Activity;Research Personnel;responders and non-responders;Rest;retention rate;Rewards;Risk;Rural;Sampling;Scientist;secondary outcome;Shoshone Indians;skills;Spirituality;Statistical Data Interpretation;statistics;Structure;Substance Use Disorder;Technology;Theoretical model;Time;Training;Tribes;underserved community;United States National Institutes of Health;Urine;Writing;young adult;Youth

PROJECT_TITLE: Culturally Re-Centering Contingency Management and Behavioral Economics to Increase Engagement with American Indian Young Adults

STUDY_SECTION: AA

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences

PI_NAMEs: GRINBERG, LEA TENENHOLZ (contact)

PROJECT_TERMS: 17q21;African ancestry;Area;automated analysis;Autopsy;Biocompatible Materials;Biology;biomarker identification;Brain;Brain Diseases;brain tissue;Caucasians;Chromosomes;Clinical;Complex;Data Analyses;data management;Database Management Systems;Databases;design;Disease;Event;Experimental Models;experimental study;Female;Fostering;Freezing;Frontotemporal Lobar Degenerations;Funding;Genetic;Genomics;Goals;Grant;Haplotypes;Human;Human Biology;human tissue;in vitro Assay;Leadership;Link;male;Maps;meetings;Midbrain structure;Middle frontal gyrus structure;Modeling;multiplex assay;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neuropathology;Neurosciences;Pathogenicity;Pathology;Patients;Positioning Attribute;Productivity;programs;Progressive Supranuclear Palsy;Proteomics;Publications;putamen;Research;Research Personnel;Research Support;Risk;Role;Sampling;Shipping;spatial relationship;Specimen;Structure of inferior temporal gyrus;Structure of superior frontal gyrus;System;tau mutation;tau Proteins;Tauopathies;therapeutic target;Tissue Stains;Tissues;tool;Training;translational neuroscience;Validation;Work

PROJECT_TITLE: Core C: Human Tissue Validation


PHR: The Functional Outcomes Core (Core B) will provide a standardized set of musculoskeletal assay services to facilitate completion of the broader goals and objections of the Program Project goals and specific aims. The Core will serve as the major center for data collection related to bone and muscle metabolism, and as such represents a key component linking the individual projects. Moreover, the Core seeks to develop new technologies in support of future research activities related to the objectives of the Program Project grant.

PI_NAMEs: MCGEE-LAWRENCE, MEGHAN E. (contact)

PROJECT_TERMS: Address;age related;age related changes;Age-Related Bone Loss;Aging;Animal Model;Area;Aryl Hydrocarbon Receptor;Biochemical Markers;Biochemistry;Biological Assay;biomechanical test;Biomechanics;bone;bone loss;bone metabolism;bone strength;bone turnover;Collection;Consult;Data Collection;Densitometry;Development;Dioxygenases;Dual-Energy X-Ray Absorptiometry;Ensure;experience;Feedback;frailty;functional outcomes;Generations;Goals;Histology;Image;In Situ Hybridization;Individual;indoleamine;Kynurenine;Link;microCT;Molecular;mouse model;Muscle;Muscle function;muscle metabolism;Muscular Atrophy;Musculoskeletal;Neuromuscular Junction;new technology;novel;Outcome;Phenotype;Preparation;Program Research Project Grants;programs;Receptor Activation;Reproducibility;Research;Research Activity;Research Personnel;Serum;Services;Signal Pathway;Signal Transduction;Specimen;Standardization;Techniques;Technology;Testing;Time;Tissues;Universities

PROJECT_TITLE: CORE B - Functional Outcomes Core


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Despite remarkable progress in reducing mortality from infectious diseases during the 20th century, in 2020 humanity faces three major growing infectious disease threats: 1) emerging infections; 2) antimicrobial resistance; and 3) synthetic pathogens. Well trained epidemiologists are critical to inform and guide the societal response to these worsening and unprecedented threats. This infectious disease epidemiology training program will produce researchers with the skills necessary to confront these 21st century threats.

PI_NAMEs: LABEAUD, ANGELLE DESIREE;LUBY, STEPHEN PATRICK (contact)

PROGRAM_OFFICER_NAME: BROWN, LILIANA L

PROJECT_TERMS: Infectious Disease Epidemiology

PROJECT_TITLE: Global Epidemiology of Infectious Diseases

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Aging;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

PHR: Project Narrative The main purpose of the Cellular Aging Core (Core C) is to isolate and distribute mouse bone marrow-derived mesenchymal stem/progenitor cells (MSCs) and primary myoblasts, and provide services for hypoxic cell culture, multiplex cytokine assays, mitochondrial function assays, and Cre-expressing adenovirus production and infection for the Program Project. The Core C is essential for the success of the Program Project as all individual projects in the Program will need to use the same cells and standardized services in order for the data sets generated from individual projects are comparable, consistent and synergistic.

PI_NAMEs: SHI, XINGMING  (contact)

PROJECT_TERMS: Address;Adenoviruses;Aging;Autophagocytosis;Biological Assay;Biology;bone;bone marrow mesenchymal stem cell;C57BL/6 Mouse;Cell Aging;Cell Culture Techniques;Cell Hypoxia;Cells;Cellular Assay;Collaborations;Collection;Core Facility;cost;cytokine;Data;Data Set;design;Detection;Discipline;Disease;Elements;Ensure;Faculty;Genus Hippocampus;Health;Individual;Infection;interest;Knock-out;Kynurenine;Laboratories;Mesenchymal Stem Cells;Mitochondria;Modeling;mouse model;multidisciplinary;Mus;Muscle;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;Myoblasts;Procedures;Production;Program Research Project Grants;programs;Quality Control;Reagent;Reproducibility;Research;Research Personnel;Resources;Role;Services;sound;Standardization;stem cells;success;Techniques;Testing;Time;Transgenic Organisms;Trust;Tryptophan;Work

PROJECT_TITLE: CORE C - Cellular Aging Core


NIH_SPENDING_CATS: Aging;Genetics;Nutrition;Osteoporosis

PHR: Project 1 will examine the harmful effects of a breakdown product of the essential amino acid tryptophan on bone. This metabolite, kynurenine accumulates with age and negatively impacts skeletal mass. Proposed studies will examine whether these age- related detrimental effects can be reversed by use of selective tryptophan metabolites.

PROJECT_TERMS: Address;Adipocytes;Age;age related;Age-Related Bone Loss;aged;Aging;Amino Acids;Animal Model;Antioxidants;Area;Aromatic Amino Acids;Aryl Hydrocarbon Receptor;Binding;bone;bone cell;bone loss;Bone Marrow;bone mass;bone metabolism;C57BL/6 Mouse;Cell Aging;Cell Proliferation;Country;Data;detection of nutrient;Disease;Environment;Enzymes;epigenetic aging;Epigenetic Process;Essential Amino Acids;Exhibits;feeding;Fracture;Generations;Goals;Health;healthspan;High Fat Diet;Human;human old age (65+);Immune system;improved;In Vitro;in vivo;Inflammation;inhibitor;Injections;innovation;Interferons;Knock-out;Knockout Mice;Kynurenine;loss of function;Marrow;Measures;Mediating;Melatonin;methyl tryptophan;microCT;Mitochondria;Modeling;Modification;Molecular;mouse model;Mus;muscle aging;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;new therapeutic target;Nutrient;old mice;Osteoblasts;Osteocytes;Osteogenesis;Osteoporosis;Osteoporotic;Outcome;oxidation;Pathogenicity;Pathway interactions;Phenotype;Physiological;Picolinic Acids;Play;Population;prevent;Process;programs;Publishing;Quinolinic Acid;Reactive Oxygen Species;Receptor Activation;Reporting;Role;sensor;sex;Sex Differences;Signal Transduction;skeletal;Stromal Cells;synergism;Testing;Tissues;treatment group;Tryptophan;Tryptophan 2,3 Dioxygenase;Tryptophan Metabolism Pathway;Xanthurenic Acid

PROJECT_TITLE: PROJECT 1 - Impact of Bone Cell-Specific IDO1 Knockout on Kynurenine Levels/AhR Activation and the Aging Musculoskeletal Phenotype


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Data Science;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

PI_NAMEs: CHANG, TIMOTHY S (contact)

PROJECT_TERMS: 17q21;Acceleration;Algorithmic Analysis;Algorithms;Alzheimer's Disease;Bioinformatics;Biological;Biometry;Biostatistics Core;brain tissue;Cell Nucleus;Chromatin;Chromatin Structure;Chromosomes;Code;Collaborations;Communication;Communities;computer infrastructure;Computer software;Data;Data Analyses;data analysis pipeline;data communication;data harmonization;Data Set;data sharing;data standards;Data Storage and Retrieval;data visualization;Database Management Systems;diverse data;Doctor of Medicine;Doctor of Philosophy;electronic data capture system;Ensure;epigenomics;experience;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Funding;Future;Gene Expression;Generations;Genetic;genetic risk factor;Genetic Variation;Genomics;Goals;Government;Grant;Haplotypes;Human Resources;human tissue;In Vitro;Informatics;Infrastructure;Inherited;Laboratories;large datasets;MAPT gene;Medicine;Messenger RNA;Metadata;Modeling;Monitor;multiple data types;multiple omics;Mutation;Nerve Degeneration;Neurodegenerative Disorders;neurogenetics;neurogenomics;Neurology;Performance;Process;Productivity;professor;Progressive Supranuclear Palsy;Proteins;Proteomics;Quality Control;Regulatory Element;Reproducibility;Research;Research Personnel;Resolution;Resource Sharing;Resources;Risk;RNA Splicing;Scientist;sharing platform;Site;Software Engineering;Source Code;statistics;System;tau Proteins;transcription factor;transcriptomics;United States National Institutes of Health;Untranslated RNA;user-friendly;Visualization software

PROJECT_TITLE: Core D: Data


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: CLEVELAND

ORG_NAME: CLEVELAND STATE UNIVERSITY

ORG_STATE: OH

PHR: Despite major advances in cardiovascular research, there are significant and unacceptable disparities in healthcare in our underserved populations, for example, risk of heart failure, sudden cardiac death, and obesity is doubled in African Americans, death from stroke is four times greater than majority populations. Yet too few members of disadvantaged populations achieve careers in the STEM workforce. Given the urgent need to redress these inequities, Cleveland State University will partner with the Cleveland Clinic to offer the first T32 training program in Cleveland to recruit pre-doctoral students from those populations underserved and underrepresented in the STEM workforce. !

PI_NAMEs: BOND, MEREDITH  (contact);MORAVEC, CHRISTINE S

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Cardiovascular system;Science;STEM career;Training Programs

PROJECT_TITLE: CD-Cavs: Cross-Disciplinary Cardiovascular Sciences Training Program to Diversify the STEM workforce


NIH_SPENDING_CATS: Aging;Osteoporosis

PHR: Muscle and bone loss with age are underlying factors contributing to falls and fractures in the elderly. These fractures are very costly both in terms of financial burden and quality of life. This project will determine whether inhibitors of the kynurenine pathway, a key pathway involved in aging, can improve muscle and bone function with aging as a strategy to prevent falls and fractures.

PI_NAMEs: HAMRICK, MARK W (contact)

PROJECT_TERMS: Ablation;Address;Adult;Age;age related;age related changes;Age-Related Bone Loss;Aging;Agonist;Animals;Aryl Hydrocarbon Receptor;Biological Aging;Biology;bone;bone aging;Bone Density;bone loss;bone mass;Cell Aging;clinical practice;cost;Cre lox recombination system;cytokine;Data;Diagnosis;Disease Outcome;Elderly;Enzymes;Exposure to;Fall prevention;falls;Financial Hardship;Fracture;frailty;Functional disorder;Future;Goals;healthspan;human subject;Impairment;improved;In Vitro;in vivo;indexing;Inflammation;inhibitor;Intervention;Knowledge;Kynurenine;life span;Ligands;LoxP-flanked allele;Measures;Mediating;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Muscle;Muscle Cells;Muscle Fibers;muscle form;Muscle function;Muscular Atrophy;Musculoskeletal;Neuromuscular Junction;old mice;Osteoporosis;Outcome;Outcome Measure;Oxidative Stress;Pathology;Pathway interactions;patient population;pharmacologic;Play;Process;Production;Public Health;Quality of life;Reactive Oxygen Species;Receptor Activation;Receptor Inhibition;Regulation;Research;Role;sarcopenia;senescence;Serum;Sex Differences;Skeletal Muscle;Skeleton;targeted treatment;Testing;Tissues;transcription factor;Tryptophan;Tryptophan 2,3 Dioxygenase

PROJECT_TITLE: PROJECT 2 - Kyn-AhR interactions modulating muscle-bone crosstalk with aging


NIH_SPENDING_CATS: Aging;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

PHR: In the current application, we will test our hypothesis that inhibition of KYN-AhR signaling in bone and bone marrow stromal cells can effectively prevent or reduce age-dependent bone loss. Furthermore, we will determine the molecular mechanisms by which KYN-AhR signaling modulates mitophagy/autophagy and premature senescence in bone marrow stromal cells and bone cells.

PI_NAMEs: FULZELE, SADANAND TUKDOJI (contact)

PROJECT_TERMS: Address;Affect;Age;age related;age-related disease;Aging;Aryl Hydrocarbon Receptor;Autophagocytosis;Biological Markers;Biomechanics;bone;bone aging;bone cell;bone loss;Bone Marrow;bone marrow mesenchymal stem cell;Bone Marrow Stem Cell;bone mass;Complex;Data;Deterioration;Enzymes;Functional disorder;Gene Expression;Generations;genetic manipulation;Goals;Impairment;improved;In Vitro;in vivo;inhibitor;Knockout Mice;Knowledge;Kynurenic Acid;Kynurenine;Lead;Membrane Potentials;Metabolic Pathway;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Molecular;Muscular Atrophy;Musculoskeletal;novel;novel therapeutic intervention;old mice;Osteogenesis;osteogenic;Outcome;Pathologic;Pathway interactions;pharmacologic;Pilot Projects;premature;prevent;Proteins;Publishing;Quinolinic Acid;Reactive Oxygen Species;Receptor Activation;Receptor Inhibition;Receptor Signaling;Reporting;response;Role;senescence;senescence associated secretory phenotype;Signal Pathway;Signal Transduction;stem cell differentiation;stem cell function;stem cell proliferation;stem cells;Stress;Stromal Cells;Testing;Therapeutic;Tissues;transcription factor;translational approach;translational potential;Tryptophan

PROJECT_TITLE: PROJECT 3 - Kynurenine-AhR Signaling Effects on Mitophagy and Senescence with Age in Bone Marrow Stem Cells


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PROJECT_TERMS: 17q21;3-Dimensional;Address;African ancestry;Astrocytes;ATAC-seq;Biological Assay;brain tissue;causal variant;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Structure;Chromosomes;clinical phenotype;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;CRISPR screen;CRISPR-mediated transcriptional activation;Dementia;differential expression;Disease;disorder risk;Enhancers;Epigenetic Process;European ancestry;Frontotemporal Dementia;functional genomics;Gene Expression;Gene Expression Regulation;gene function;Genes;Genetic;genetic association;genome wide association study;Genomics;Goals;Haplotypes;Hi-C;Human;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;Investigation;Linkage Disequilibrium;Methods;Microglia;Modernization;Molecular;multiple omics;Mutation;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurons;novel therapeutic intervention;Pathology;Pathway interactions;Patients;Population;prevent;Progressive Supranuclear Palsy;protective effect;protein expression;Protein Isoforms;Protein Splicing;Proteomics;Regulatory Element;Risk;Risk Factors;risk variant;RNA Splicing;Signal Transduction;Spliced Genes;stem cell model;Structure;targeted treatment;tau Proteins;Tauopathies;Testing;transcriptome;transcriptome sequencing;transcriptomics;Variant;Work;XCL1 gene

PROJECT_TITLE: Project 1: Determination of molecular differences caused by tauopathy-associated H1 and H2 haplotypes


PHR: This project will test the hypothesis that kynurenine (Kyn) and its signaling through the aryl hydrocarbon receptor (AhR) are critical components of aging-related musculoskeletal dysfunction, and that the sexually dimorphic effects of Kyn are attributed to crosstalk between Kyn/AhR ligand-regulated, DNA-binding transcription factors in the nuclear receptor superfamily including the estrogen receptor (ER alpha/beta) and the glucocorticoid receptor (GR).

PROJECT_TERMS: Address;Adipose tissue;Age;age related;Age-Related Bone Loss;aged;Aging;aging related;anastrozole;Androgen Antagonists;Androgen Receptor;Androgens;antagonist;ARNT gene;Aromatase Inhibitors;Aryl Hydrocarbon Receptor;aryl hydrocarbon receptor ligand;Biological;biological adaptation to stress;Biological Assay;Body System;bone;Bone Marrow;bone mass;bone strength;bone turnover;Cell Energetics;Cell Lineage;Cells;ChIP-seq;circadian regulation;Collaborations;Combined Modality Therapy;Complex;conditional knockout;Data;Dexamethasone;DNA Binding;Dual-Energy X-Ray Absorptiometry;Enzymes;ESR1 gene;Estradiol;Estrogen Receptors;experimental study;Female;Flutamide;frailty;Functional disorder;Genes;Genetic Transcription;Genomics;Glucocorticoid Receptor;Glucocorticoids;Goals;Hematopoietic stem cells;Homeostasis;Impairment;In Vitro;in vivo;inhibitor;interest;Knockout Mice;Kynurenic Acid;Kynurenine;Ligands;Link;Maintenance;male;Measures;Mechanics;Mediating;Mediator;men;microCT;Mifepristone;Mitochondria;Modeling;Molecular;Mus;Muscular Atrophy;Musculoskeletal;Musculoskeletal System;novel;Nuclear Receptors;Nuclear Translocation;Orchiectomy;Osteoblasts;Osteoclasts;Osteoporosis;osteoprogenitor cell;Ovariectomy;Phenotype;Picolinic Acids;Play;Population;Procedures;Production;Proliferating;Publishing;Receptor Cross-Talk;receptor function;Receptor Signaling;receptor-mediated signaling;Regulation;Research;response;Role;senescence;sexual dimorphism;Signal Transduction;skeletal;Skeleton;Stromal Cells;Testing;transcription factor;Tryptophan;Women's prevalence;young adult

PROJECT_TITLE: PROJECT 4 - Kyn-AhR crosstalk with nuclear receptor-mediated signaling in skeletal aging


ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE – Overall This Program renewal will provide evidence to improve the equity and effectiveness of breast cancer screening and surveillance. We will create risk prediction tools that perform well for all racial and ethnic groups and examine factors that influence the quality of breast imaging across radiology facilities to identify opportunities to improve care. Our findings will provide timely information to inform decision making about the frequency and type of breast cancer screening and surveillance for women, healthcare providers, and policymakers.

PI_NAMEs: KERLIKOWSKE, KARLA M;MIGLIORETTI, DIANA L (contact);TOSTESON, ANNA N. A.

PROGRAM_OFFICER_NAME: CROSWELL, JENNIFER

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;algorithmic bias;Artificial Intelligence;artificial intelligence algorithm;Attention;Biometry;Breast Cancer Detection;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;Breast Cancer survivor;breast imaging;Cancer Etiology;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer risk;care delivery;Caring;Cessation of life;Clinical;clinical risk;Communication Research;Communities;Community Practice;comparative effectiveness;Data;Data Collection;data management;Decision Making;Digital Breast Tomosynthesis;Disparity;Early Diagnosis;Education;Effectiveness;Equity;ethnic disparity;Ethnic Origin;Ethnic Population;evidence base;Failure;Frequencies;Funding;Future;General Population;Geography;Goals;Guidelines;Harm Reduction;health disparity;health equity;Health Personnel;high risk;High Risk Woman;Housing;Image;imaging facilities;Imaging technology;improved;Income;Individual;Inequity;Infrastructure;innovation;Intervention;Leadership;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Modeling;mortality;multidisciplinary;Neighborhoods;network models;Outcome;patient oriented;Performance;Play;Policies;Policy Maker;Population;population based;Population Heterogeneity;predictive tools;programs;prospective;Provider;Public Health;public health priorities;Qualitative Research;Race;racial disparity;racial population;Radiology Specialty;Registries;Research;Resources;Risk;Risk Assessment;Risk Factors;risk prediction;risk prediction model;Role;Science;screening;Services;social health determinants;sociodemographics;socioeconomics;Stage at Diagnosis;Structural Racism;surveillance imaging;surveillance strategy;System;Technology;Testing;training data;Translations;Underserved Population;United States;United States National Institutes of Health;Woman

PROJECT_TITLE: Advancing Equitable Risk-based Breast Cancer Screening and Surveillance in Community Practice


NIH_SPENDING_CATS: Aging;Neurosciences

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE The human brain has approximately equal numbers of glia cells and neurons, and interactions between these cells are essential for all nervous system functions. Impaired glia-neuron interactions underlie many neurological diseases including Alzheimer’s disease, Autism, epilepsy and may contribute to age-related neural decline. To understand glial contribution to nervous system health, aging and disease, we will dissect glia-neuron interactions with exquisite speed and molecular resolution in vivo by using a powerful genetic model we recently established.

PI_NAMEs: SINGHVI, AAKANKSHA  (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Age;age related;age related decline;Aging;Alzheimer's Disease;Animal Behavior;Animals;autism spectrum disorder;Binding;Biological Assay;Brain;Caenorhabditis elegans;Cell Shape;cell type;Cells;Cellular biology;cellular imaging;Code;combinatorial;connectome;Cues;Dendritic Spines;Disease;disease model;Dissection;Environment;Epilepsy;Functional Imaging;Future;Genes;Genetic;Genetic Models;Genomics;Goals;Health;Health system;Hermaphroditism;Human;Impairment;in vivo;Individual;information processing;Instruction;Interneurons;Kinetics;Learning;life span;Logic;Maps;Memory;Modeling;Molecular;Monitor;mutant;Nervous System;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neuroglia;Neurons;Neurophysiology - biologic function;novel;Parkinson Disease;Pathway interactions;Perception;Property;Protein Biochemistry;proteostasis;Reproducibility;Research;Resolution;Role;Sensory;sex;Shapes;Site;Specific qualifier value;Specificity;Speed;Study models;System;Techniques;Testing;tool

PROJECT_TITLE: Molecular dissection of glia-neuron interactions

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ORG_CITY: COLUMBIA

ORG_NAME: UNIVERSITY OF MISSOURI-COLUMBIA

ORG_STATE: MO

PHR: PROJECT NARRATIVE Residents in United States nursing homes are particularly vulnerable to serious illness or death related to COVID-19 in part due to their physical frailty, but also due to the communal living environment. The goal of this project is to develop knowledge and recommendations to improve US nursing homes’ ability to respond to respiratory infection outbreaks such as COVID-19, in order to reduce risk of harm.

PI_NAMEs: POPEJOY, LORI LEA;VOGELSMEIER, AMY ANN (contact)

PROJECT_TITLE: Developing improved guidelines for nursing home-associated viral respiratory infections: Learning from the COVID-19 experience


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE – Project 1  Project 1 will develop and validate new models to predict women’s advanced breast cancer risk, and evaluate  the comparative effectiveness of screening interventions based on advanced cancer risk. Our findings will  inform clinical practice and national guidelines by determining how equitable breast cancer screening  strategies can be targeted based on women’s advanced cancer risk to maximize benefits while minimizing  harms.

PI_NAMEs: KERLIKOWSKE, KARLA M (contact)

PROJECT_TERMS: advanced breast cancer;Advanced Malignant Neoplasm;Age;aged;Algorithms;American Joint Committee on Cancer;Area;Artificial Intelligence;artificial intelligence algorithm;Biopsy;Black race;Breast Cancer Detection;breast cancer diagnosis;Breast Cancer Risk Factor;Breast Cancer Surveillance Consortium;breast imaging;Breast Microcalcification;Cancer Intervention and Surveillance Modeling Network;cancer invasiveness;cancer risk;Cessation of life;Characteristics;Clinical;clinical practice;clinical risk;Collaborations;Community Practice;comparative effectiveness;Data;discrete time;Discrimination;Effectiveness;Equity;ethnic disparity;Ethnic Origin;experience;Focus Groups;Frequencies;Funding;Goals;Guidelines;Harm Reduction;high risk;High Risk Woman;Image;improved;improved outcome;Incidence;Intervention;Interview;Life;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Mammographic screening;Mammography;Modality;Modeling;models and simulation;Modernization;mortality;novel;Outcome;Output;Pathologic;Patient Self-Report;Performance;Physicians;Population;predictive modeling;prognostic;Provider;Race;racial disparity;Racial Equity;randomized trial;Recommendation;Registries;Risk;Risk Factors;risk prediction;risk prediction model;routine screening;screening;Services;social health determinants;Statistical Methods;targeted imaging;White Women;Woman;women's diagnosis;Women's Group

PROJECT_TITLE: Project 1


ORG_NAME: CLEVELAND CLINIC FOUNDATION

PHR: Public Health Relevance/Project Narrative Community-acquired pneumonia (CAP) is a leading cause of hospitalization and inpatient antimicrobial use in the United States. However, diagnostic uncertainty at the time of initial treatment and following negative cultures is associated with prolonged exposure to broad-spectrum antimicrobials. We propose a large multicenter cluster randomized controlled trial to test two approaches to reducing the use of broad-spectrum antibiotics in adult patients with CAP a) routine use of rapid diagnostic testing at the time of admission and b) pharmacist-led de-escalation after 48 hours for clinically stable patients with negative cultures.

PI_NAMEs: DESHPANDE, ABHISHEK ;ROTHBERG, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: HENDERSON, SUSAN

PROJECT_TITLE: Reducing Antimicrobial Overuse Through Targeted Therapy for Patients with Community-Acquired Pneumonia

STUDY_SECTION: HEOR

STUDY_SECTION_NAME: Healthcare Effectiveness and Outcomes Research[HEOR]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Women's Health Research

PHR: PROJECT NARRATIVE – Project 2  Women of minority race/ethnicity, lower income, lower education, and rural residence have limited access to  higher quality breast cancer screening and newer technologies that can detect more cancer and reduce  unnecessary diagnostic follow-up. The proposed study will comprehensively evaluate how targeted facility-  level changes, including the use of artificial intelligence for automated mammography interpretation, can  promote greater equity in breast cancer screening outcomes. This study will generate evidence to guide  practitioners and policymakers in optimizing the quality of care in cancer screening and reducing  the unequal  burden of cancer in our society.

PI_NAMEs: LEE, CHRISTOPH I (contact)

PROJECT_TERMS: Academy;Adherence;Adopted;Adoption;Advanced Malignant Neoplasm;Artificial Intelligence;artificial intelligence algorithm;Attention;Automobile Driving;Benchmarking;black women;Breast;Breast Cancer Detection;Breast Cancer Surveillance Consortium;breast imaging;Cancer Burden;Cancer Detection;cancer health disparity;Cancer Intervention and Surveillance Modeling Network;cancer invasiveness;Caring;case control;clinical practice;cohort;Communities;Community Practice;cost;Data;design;Diagnosis;Diagnostic;Diffusion;Digital Breast Tomosynthesis;Digital Mammography;Disease;Disparity;Education;Enabling Factors;Equilibrium;Equity;ethnic minority;Ethnic Origin;Evaluation;experience;follow-up;General Population;health care delivery;health equity;health equity promotion;Health equity research;Image Analysis;image guided;imager;imaging facilities;Imaging technology;improved;Income;Individual;Inequity;innovation;Insurance;Intervention;Low income;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;Medicine;models and simulation;Morbidity - disease rate;mortality;multilevel analysis;National Institute on Minority Health and Health Disparities;Neighborhoods;new technology;observational cohort study;Outcome;patient navigation;Performance;Policy Maker;Population;Quality of Care;racial minority;racial minority women;radiologist;Registries;Reporting;Research;Research Design;Resources;Risk;routine screening;Rural Population;rural residence;screening;screening disparities;Screening for cancer;Sensitivity and Specificity;Services;Site;social health determinants;Societies;structural determinants;Structural Racism;Technology;Time;tool;Training;underserved community;Underserved Population;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Project 2


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Project Narrative Some people age significantly more gracefully than others, and understanding the neural factors that underlie those individual differences could lead to interventions to slow or even stop age-related behavioral impairments. The objective of this project is to investigate two neural factors that may play a role, namely age-related changes in the distinctiveness of neural representations and age-related changes in the variability of neural signals. This research could lead to the development of better preclinical markers of Alzheimer’s disease and open avenues for pharmaceutical interventions to slow cognitive declines in aging.

PI_NAMEs: LALWANI, POORTATA SHIRISH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: Address;Adult;Age;age difference;age related;age related changes;age related decline;Age-associated memory impairment;Aging;Alzheimer's Disease;Amyloid;Animal Experimentation;Auditory area;base;Behavior;behavior test;Behavioral;behavioral impairment;Biological Markers;Brain;Categories;Clinical;Cognition;Cognitive;cognitive function;cognitive performance;cognitive task;Computer Models;Data;Data Set;design;Development;experience;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Glutamates;Glutamine;healthy aging;Hippocampus;Human;Impaired cognition;Impairment;Individual Differences;Intervention;Lead;Life;Liquid substance;Magnetic Resonance Spectroscopy;Measures;Memory;Memory impairment;mild cognitive impairment;Modality;Motor;Motor Cortex;Nerve Degeneration;neural;neurochemistry;neurotransmission;Neurotransmitters;normal aging;older adult;Participant;Pathologic;pathological aging;Pathology;Patients;Pattern;Performance;Persons;pharmacologic;Pharmacologic Substance;Phase;Population;Positron-Emission Tomography;Postdoctoral Fellow;pre-clinical;pre-doctoral;preclinical development;Research;Research Project Grants;response;Rest;Role;Sensory;Signal Transduction;Spectrum Analysis;Standardization;Stimulus;Task Performances;tau Proteins;Testing;Training;Visual Cortex;visual stimulus;Work;young adult

PROJECT_TITLE: The scope, cause and consequences of age-related decline in neural distinctiveness and brain signal variability in healthy and pathological aging