ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Cardiovascular;Clinical Research;Congenital Heart Disease;Congenital Structural Anomalies;Down Syndrome;Genetic Testing;Genetics;Health Services;Heart Disease;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Rare Diseases;Social Determinants of Health

ORG_CITY: IRVINE

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: Millions of individuals in Low-to-Middle-Income Countries are affected by birth defects, representing a major global Public Health burden. We propose innovative low-cost strategies for reducing the impact of birth defects, based on mobile, facial recognition software to screen for dysmorphic syndromes (including Down syndrome), coupled with practical genetic solutions for early diagnosis in the Democratic Republic of the Congo (DRC). Our partnership between Institut National de Recherche Biomédicale, a DRC national research institute, and Children's National Hospital in Washington, DC, will create the infrastructure of a birth defect Registry, allowing for future surveillance and intervention programs in low resource settings.

PI_NAMEs: LINGURARU, MARIUS GEORGE ;MUMBA, NGOYI ;VILAIN, ERIC J. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Accounting;accurate diagnosis;Address;Affect;Aneuploidy;Appearance;Artificial Intelligence;Biometry;Birth Rate;burden of illness;Capillary Electrophoresis;Caring;Cellular Phone;Cheek structure;Child;Child Mortality;Competence;computer scientist;Computer software;computerized;Congenital Abnormality;congenital anomaly;Congenital Heart Defects;Copy Number Polymorphism;cost;Country;Coupled;Data;data acquisition;data registry;Databases;Democratic Republic of the Congo;design;Detection;Development;Diagnosis;Diagnostic;diagnostic screening;diagnostic technologies;disability;Disease;DNA sequencing;Down's Syndrome;Early Diagnosis;empowerment;Environment;Environmental Risk Factor;Ethics;Ethnic Origin;Face;facial recognition software;Family;Fellowship;follow-up;Future;General Population;Genetic;Genetic Diseases;genetic disorder diagnosis;Genetic Materials;Genetic Predisposition to Disease;genetic resource;global health;Health;health care quality;health care service;Health Personnel;Healthcare;Hearing;High Prevalence;Hospitals;improved;Income;Individual;Infection;Infrastructure;innovation;innovative technologies;insertion/deletion mutation;International;Intervention;intervention program;Laboratories;Machine Learning;Materials Testing;Measures;mhealth interventions;Modeling;Morbidity - disease rate;Morphology;mortality risk;neonatal health;Neonatal Screening;Newborn Infant;novel;novel strategies;nutrition;Other Genetics;Outcome;Patient risk;Persons;Phenotype;Photography;Physicians;Pilot Projects;Point Mutation;point of care;Population;Population Heterogeneity;Population Surveillance;Prevalence;prevent;programs;Public Health;Publications;rapid diagnosis;Registries;Research Institute;Resource Allocation;Resource-limited setting;Resources;Sampling;screening;Services;smartphone application;Societies;standard of care;Students;Surveillance Program;Swab;Syndrome;System;Technology;Testing;Time;tool;Training;transposon/insertion element;Washington

PROJECT_TITLE: Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: MINNEAPOLIS

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Significant knowledge gaps still exist regarding a full understanding of HIV replication. Many fundamental aspects of human retrovirus replication, including virus particle assembly, remain understudied, and will be investigated in this proposal by using cutting-edge biophysical technologies. These basic science investigations of HIV assembly will help address crucial knowledge gaps as well as help inform efforts toward next-generation HIV therapies.

PI_NAMEs: ARNDT, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Amino Acids;Anti-Retroviral Agents;Anti-viral resistance;antiretroviral therapy;antiviral drug development;Architecture;Basic Science;Binding;Biological Process;Biophysics;C-terminal;Capsid;Capsid Proteins;CASP1 gene;Cessation of life;Characteristics;comparative;Cryoelectron Microscopy;Development;Disease;experimental study;gag Gene Products;Geography;HIV;HIV therapy;HIV-1;Human;In Vitro;Individual;Infection;inhibitor;insight;Integrase;Investigation;Knowledge;Link;Maps;Membrane;Modality;Molecular;Morphogenesis;Morphology;next generation;NIH Office of AIDS Research;novel;particle;Pathogenicity;Pathway interactions;Peptide Hydrolases;Persons;Prevalence;Process;Protein Analysis;protein protein interaction;protein structure;Research;resistance mechanism;Resolution;Retroviridae;Reverse Transcriptase Inhibitors;Role;Site-Directed Mutagenesis;Structure;Structure-Activity Relationship;success;targeted treatment;Technology;Testing;Therapeutic Intervention;transmission process;Tube;Viral;Viral Drug Resistance;Virion;Virus;Virus Diseases;virus morphology;Virus Replication;World Health Organization

PROJECT_TITLE: Structural characterization of the HIV-2 capsid lattice

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F17A-F (20)]


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse;Women's Health Research

ORG_DEPT: NEUROSCIENCES

PHR: PROJECT NARRATIVE This K99/R00 proposal incorporates innovative optogenetics and fiber photometry techniques to investigate alterations in synaptic plasticity and circuit dynamics during oxycodone use (self-administration), abstinence, and relapse. Specifically, the ultimate goal is to advance our mechanistic understanding of opioid use disorders, including differences between sexes.

PI_NAMEs: ALONSO CARABALLO, YANAIRA  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Abate;Abstinence;addiction;Address;Adopted;affective neuroscience;Anatomy;Animals;Anterior;Behavior;Brain;Brain region;Calcium;Calcium Signaling;cell type;Complex;Comprehension;compulsion;craving;Cue-induced relapse;Cues;daily functioning;Data;debilitating symptom;design;Desire for food;Dissection;Drug Addiction;drug of abuse;Drug usage;Electrophysiology (science);Estrous Cycle;experience;experimental study;Female;Fiber;Foundations;Future;Glutamates;Goals;Grant;Heroin;Hormones;Human;Image;Impairment;improved;in vivo;Individual;innovation;Intravenous;Knowledge;Link;long term recovery;Longitudinal Studies;male;Maps;Measures;Medical;Methodology;Modernization;Monitor;negative affect;nerve supply;neural circuit;neuromechanism;Neurons;Neurosciences;Neurotransmitters;Nucleus Accumbens;Opioid;opioid injection;opioid use;opioid use disorder;opioid withdrawal;Optics;optogenetics;Outcome;Ovarian hormone;Oxycodone;oxycodone self-administration;Pathway interactions;Pattern;Pharmaceutical Preparations;Pharmacologic Substance;Phase;Photometry;Physiological;Physiology;Postdoctoral Fellow;Prevention;programs;prolonged abstinence;psychologic;Rat Transgene;Rattus;Recovery;Relapse;relapse risk;Research;Research Personnel;Research Project Grants;response;Rewards;Risk;Rodent;Role;Self Administration;sensor;Severities;sex;Sex Differences;Sociology;Solid;Structure of paraventricular nucleus of thalamus;Symptoms;Synapses;synaptic function;Synaptic plasticity;System;Techniques;Testing;Thalamic structure;tool;transmission process;Withdrawal Symptom;women versus men;Work

PROJECT_TITLE: Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-A (56)]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE While advancements have produced modest increases in the survival of pancreatic cancer patients, the demand for novel strategies persists, necessitating a focus on combination therapies directed at emerging targets. Hence, our proposal centers on the investigation of a validated therapeutic target, Redox factor-1 (Ref- 1), both as a standalone intervention and within strategic combinations. Having progressed the initial Ref-1 inhibitor (APX3330) to a phase I clinical trial in adults, we've also identified subsequent Ref-1 inhibitors, devised a patient sensitivity screening strategy, and pinpointed molecular partners for potential synergy with Ref-1 inhibition.

PI_NAMEs: FISHEL, MELISSA L.;KELLEY, MARK R. (contact)

PROGRAM_OFFICER_NAME: CHEN, WEIWEI

PROJECT_TERMS: 3-Dimensional;Adult;advanced disease;analog;cancer cell;candidate selection;carbonate dehydratase;Cell Line;Cell Proliferation;Cells;Characteristics;Citric Acid Cycle;clinical development;Clinical Trials;Coculture Techniques;combinatorial;Combined Modality Therapy;Critical Pathways;Data;design;Development;Disease;disorder control;Dose;Drug Combinations;Drug Kinetics;Drug resistance;Environment;Enzymes;Evaluation;Exhibits;Formulation;Future;Gene Expression;Generations;Genes;Genetic Transcription;Growth;HIF1A gene;Hypoxia;Hypoxia Inducible Factor;Hypoxia-Inducible Factor Pathway;improved;In Vitro;in vivo;in vivo Model;Individual;inhibitor;innovation;Intervention;Investigation;knock-down;Lead;lead candidate;lead optimization;Malignant neoplasm of pancreas;Metabolic;metabolic abnormality assessment;Metabolic Pathway;Metabolic stress;Metabolism;Methods;Mitochondria;Molecular;Molecular Target;Mus;Neoplasm Metastasis;next generation;novel;novel strategies;novel therapeutics;nutrient deprivation;Outcome;Oxidation-Reduction;Oxidative Phosphorylation;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Parents;Pathway interactions;patient derived xenograft model;patient screening;Patient Selection;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;Phase I Clinical Trials;phase I trial;Play;pre-clinical;preclinical development;Proliferating;Reaction;Research;Resistance;resistance mechanism;response;Role;screening;Signal Transduction;Signaling Protein;Solid Neoplasm;spheroids;synergism;targeted agent;targeted treatment;Testing;Therapeutic;therapeutic target;therapy resistant;Time;Toxic effect;transcription factor;Treatment Efficacy;Triage;trial design;tumor;tumor growth;tumor metabolism;United States National Institutes of Health;Xenograft procedure

PROJECT_TITLE: Metabolic flux analysis and PDX models to understand therapeutic vulnerabilities following inhibition of Ref-1 redox signaling in pancreatic cancer


ORG_CITY: CLEVELAND

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CLEVELAND CLINIC LERNER COM-CWRU

ORG_STATE: OH

PHR: PROJECT NARRATIVE Chimeric antigen receptor (CAR)-engineered T cell therapy is a breakthrough immunotherapy for lymphoma, but poor persistence of CAR-T cells contributes to relapse. This study will unveil the role of a novel inhibitory receptor in regulating CAR-T cell persistence, thereby holding potential for improving the clinical efficacies of CAR-T therapies.

PI_NAMEs: WANG, LI LILY (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Antigen-Presenting Cells;B-Cell Activation;B-Cell Acute Lymphoblastic Leukemia;bcr-abl Fusion Proteins;Binding;CAR T cell therapy;CD28 gene;CD8-Positive T-Lymphocytes;cell type;Cells;checkpoint receptors;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;clinical efficacy;Development;engineered T cells;Equilibrium;exhaustion;Family;Future;Genetic;high reward;high risk;Human;IL27RA gene;Immune;immune checkpoint;Immunoglobulin Domain;Immunotherapy;Impairment;improved;in vitro Assay;inhibitor;Lead;Leucine-Rich Repeat;Lymphoma;Macrophage;Manuscripts;Mediating;Memory;Modeling;Monoclonal Antibodies;Mus;Myeloid Cells;neoplastic cell;next generation;Normal tissue morphology;novel;P-selectin ligand protein;Patients;Phenotype;pre-clinical;Production;Proliferating;Proteins;receptor;receptor function;Relapse;relapse patients;Reporting;Resistance;response;Role;Signal Transduction;stem;Suppressor-Effector T-Lymphocytes;T cell response;T cell therapy;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic evaluation;Treatment Efficacy;tumor;Tumor Immunity;Xenograft Model

PROJECT_TITLE: Investigating a Novel Inhibitory Receptor in Regulating CAR-T Cell Persistence and Function

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M1)]


NIH_SPENDING_CATS: Genetics;Lung

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative: Mast cells (MC) are potent inflammatory cells that arise from circulating MC progenitors (MCp) recruited to airway mucosal tissues during type 2 inflammatory diseases, including asthma and nasal polyposis, where they take on discrete intraepithelial and subepithelial phenotypes based on their tissue microenvironment. While intraepithelial MCs prominently expand within the bronchial airway epithelium in both human and mouse during allergic lung inflammation, no tools currently exist to selectively target this population for functional analysis of its contribution to disease progression. This proposal describes the creation of a pre-clinical mouse strain allowing selective targeting of intraepithelial mast cells. The proposed studies will use our novel mouse strain to test roles for intraepithelial mast cells at several discrete points in airway inflammation, setting the stage for future mechanistic studies testing the influence of specific pathways and their contribution to inflammation in other tissues.

PI_NAMEs: DWYER, DANIEL F (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: activation product;Address;airway epithelium;airway hyperresponsiveness;airway inflammation;Allergic;Asthma;Automobile Driving;Basophils;Binding;Cell Compartmentation;Cell Differentiation process;Cell Lineage;Cell Maturation;Cell Survival;Cells;Characteristics;Chymase;Connective Tissue;Coupled;Cytoplasmic Granules;Defect;Development;Disease;Disease Progression;enhanced green fluorescent protein;Enterobacteria phage P1 Cre recombinase;Eosinophilic Esophagitis;Epithelium;Erythrocytes;Exhibits;falls;Flow Cytometry;Fluorescence;Food Hypersensitivity;Foundations;Future;Genetic;Goals;granulocyte;Helminths;Human;human disease;Immunofluorescence Immunologic;improved;In Situ;in vivo;inducible Cre;Inflammation;Inflammatory;Inflammatory Response;intraepithelial;Knockout Mice;Link;link protein;Lung;Maintenance;mast cell;Megakaryocytes;Modeling;Mouse Strains;Mucositis;Mucous Membrane;Mus;Mutation;Names;Nose;novel;Pathogenicity;Pathway interactions;Patient-Focused Outcomes;Patients;Peptide Hydrolases;Peptides;Peripheral;Phase;Phenotype;Play;polyposis;Population;pre-clinical;Pre-Clinical Model;protein expression;Proto-Oncogene Protein c-kit;Pulmonary Inflammation;Pyroglyphidae;recruit;Reporter;Respiratory Disease;Respiratory Mucosa;Ribosomes;Rodent;Rodent Model;Role;selective expression;Serum;Severity of illness;Signal Transduction;stem cells;Submucosa;T-Lymphocyte;Tamoxifen;Target Populations;Testing;therapeutic target;Tissues;tool;Transcript;transcriptome sequencing;Tryptase;Up-Regulation;Urine;virtual

PROJECT_TITLE: Genetic targeting of intraepithelial mast cells

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Infectious Diseases;Wound Healing and Care

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative. Our ongoing study explores the use of Glutamate 1-Semialdehyde (GSA) in inducing porphyrin accumulation in bacteria, facilitating their visual identification and elimination via fluorescence imaging and light-based killing, notably without affecting mammalian cells. While preliminary data showcase the in vitro efficacy of GSA- phototherapy on common wound-infecting bacteria, the proposed research will delve into its detection thresholds, biosafety, and killing efficacy utilizing diabetic mice and mini-pigs. This approach proposes a multifaceted solution for the timely diagnosis, real-time monitoring, and non-antibiotic treatment of bacterial infections in diabetic wounds, potentially preventing severe outcomes like amputation and sepsis.

PI_NAMEs: LI, YONGLI  (contact)

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: Address;Adherence;Affect;Aminolevulinic Acid;Amputation;Animal Model;Antibiotics;antimicrobial;Area;authority;Bacteria;Bacterial Infections;Boston;career;career development;Cells;chemical synthesis;Chronic;Clinic;Clinical;Clinical Microbiology;Collaborations;combat wound;Complications of Diabetes Mellitus;Data;Debridement;design;Detection;Deterioration;Device Designs;Devices;Diabetes Mellitus;diabetic;Diabetic Foot Ulcer;Diabetic mouse;diabetic patient;diabetic ulcer;diabetic wound healing;Diagnosis;Effectiveness;efficacy evaluation;empowerment;Ensure;Environment;Exhibits;Exposure to;Fluorescence;fluorescence imaging;Foot Ulcer;General Hospitals;Glutamates;Goals;Grant;healing;Home;Image;Immunity;Impaired wound healing;Impairment;In Vitro;Infection;Inflammation;insight;Israel;Knowledge;Leadership;Life;Light;Location;Maintenance;Mammalian Cell;Mammals;Maps;Massachusetts;Medical center;medical schools;Mentored Research Scientist Development Award;Mentors;Metabolic Pathway;Methods;Miniature Swine;Modality;Monitor;Nature;novel;Outcome;Oxygen;pathogen;Pathway interactions;Patient Care;photonics;Phototherapy;polymicrobial biofilm;porphyrin biosynthesis;Porphyrins;Predisposition;prevent;Prodrugs;Productivity;Proliferating;Publications;Reactive Oxygen Species;real time monitoring;Research;Research Personnel;Resistance;Resource Development;Resources;Sampling;Scientist;Sepsis;Signs and Symptoms;skills;Skin;Sterile coverings;success;symposium;Techniques;Technology;Telephone;Testing;Time;timeline;tool;Training;Transferable Skills;translational potential;user-friendly;Visible Radiation;Visual;Visualization;wound;wound care;wound dressing;wound healing;Wound Infection;wound treatment;Writing

PROJECT_TITLE: Diagnosis, Treatment, and Monitoring of Polymicrobial Infections in Diabetic Wounds

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Immunization;Infectious Diseases;Pediatric;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: NARRATIVE Maternal prenatal vaccination is a promising strategy to improve pathogen-specific antibody transfer to the fetus to provide early-life immunity to immunologically vulnerable infants. However, an incomplete mechanistic understanding of how the placenta transfers antibodies from mothers to babies impedes current immunization approaches from providing adequate protection to all newborns. This project will define the underlying rules and the complex kinetics of antibody transfer and will build mathematical models to inform new prenatal vaccination strategies that better protect newborns from infections, thus saving tremendous resources by narrowing down to top strategies for clinical trials.

PI_NAMEs: DOLATSHAHI, SEPIDEH  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: adaptive immune response;Affect;Affinity;Animal Model;Antibodies;antibody transfer;Binding;Biological Assay;Budgets;Cell Line;Cells;Characteristics;Clinical Trials;Cohort Studies;Complex;Data;design;Development;emerging pathogen;Endothelial Cells;Fc Receptor;fetal;fetal capillary endothelium;Fetus;Gatekeeping;glycosylated IgG;glycosylation;Goals;Heterogeneity;high risk infant;Human;human imaging;IgG Receptors;Immune;Immunity;Immunization;Immunize;Immunofluorescence Immunologic;Immunoglobulin G;Immunologic Memory;Immunologics;improved;in silico;In Vitro;Individual;Infant;Infection;Influentials;insight;Kinetics;Length;Life;maternal vaccination;mathematical model;Mathematics;Mediating;Modeling;Mothers;neonatal Fc receptor;neonatal infection;Newborn Infant;Nonlinear Dynamics;novel;novel vaccines;Outcome;pathogen;Persons;Phenotype;Placenta;placental transfer;Play;Population;Populations at Risk;predictive modeling;Pregnancy;Pregnant Women;prenatal;Process;Public Health;rational design;receptor;receptor expression;Resources;Rodent Model;Role;Safety;Stromal Cells;success;Syncytiotrophoblast;synergism;Testing;Tissues;Vaccination;vaccination strategy;Vaccine Clinical Trial;Vaccine Design;vaccine strategy;Vaccines;Variant

PROJECT_TITLE: Mechanistic insights into the kinetics of Fc receptor-mediated placental antibody transfer to optimize maternal vaccine strategies

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 HSC-X (M1)]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: NARRATIVE Glioblastoma (GBM; isocitrate dehydrogenase [IDH]-wild-type) is a lethal tumor with poor treatment options due to a high rate of resistance to both chemotherapy and radiotherapy. Perturbing mitosis, the process of one cell dividing into two, is a vulnerability in solid tumors, including GBM. Successful completion of this project will identify a means of blocking mitosis in GBM that will not only function to limit tumor growth but will also enhance the efficacy of current GBM therapy.

PI_NAMEs: SUMMERS, MATTHEW K (contact);VENERE, MONICA

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Antimitotic Agents;Astrocytes;Biological Assay;Brain;Brain Neoplasms;cancer cell;Cell division;Cell Line;Cell Survival;Cells;Cellular biology;Central Nervous System Neoplasms;Characteristics;Chemotherapy and/or radiation;Chromosomal Instability;Chromosomes;Clinical Trials Design;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;comparative efficacy;Cytokinesis;Data;Defect;Dependence;DNA Damage;Dose;Enzymes;Failure;Future;Genetic;Glioblastoma;Human;In Vitro;in vivo;inhibitor;insight;Isocitrate Dehydrogenase;Kinesin;Knock-out;Knowledge;Malignant Neoplasms;Mediating;Microtubules;Mitosis;Mitotic;Modeling;neurotoxicity;novel therapeutic intervention;overexpression;Pathway interactions;patient derived xenograft model;Patients;Poison;Polyploidy;pre-clinical;preclinical study;prevent;Process;Prognosis;Prometaphase;Radiation;Radiation therapy;Radiation-Sensitizing Agents;Radiosensitization;Recurrence;Refractory;Reporting;Research;Resistance;RNA Interference;Role;small molecule;Solid Neoplasm;standard of care;targeted agent;targeted treatment;taxane;Testing;Therapeutic;therapeutic development;therapeutic target;Therapeutic Uses;tool;translational potential;tumor;tumor growth;Work;Xenograft procedure

PROJECT_TITLE: Investigating KIF20A as a therapeutic target in glioblastoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-P (M1)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: SEATTLE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project narrative I will adapt my parental psychological control questionnaire to Mexican immigrant families via mixed methods (K99) and test cultural mechanisms of parental psychological control longitudinally (R00). This project will provide a reproducible methodology to create culturally sensitive measures of parental psychological control based on what people in a specific culture believe to be intrusive and also provide me with the training in family observations and interviews and in Latinx parenting. This training will equip me to become an independent researcher who studies parenting in diverse cultures via multiple methods and implements culturally sensitive preventive interventions for ethnically diverse families.

PI_NAMEs: CHOE, SOYOUNG  (contact)

PROGRAM_OFFICER_NAME: ESPOSITO, LAYLA E

PROJECT_TERMS: 12 year old;15 year old;Address;Adolescent;Adopted;Adverse effects;aged;Aggressive behavior;Area;Award;Behavior;behavior observation;Belief;career;caucasian American;Child;Child Development;Child Health;Child Rearing;Child Welfare;Competence;Data;Data Analyses;Data Analytics;Data Collection;Development;Eligibility Determination;Emotional;emotional behavior;Ensure;Equity;ethnic diversity;European;Exclusion;experience;Expressed Emotion;Family;Fathers;First Generation College Students;Foundations;Friends;Future;Gender;Gender Role;Goals;Guilt;Health;Immigrant;Immigrant family;Impairment;improved;Intervention;Interview;Latinx;Literature;Longitudinal Studies;Measurement;Measures;Mediating;Mental Health;Methodology;Methods;Mexican;Mexico;minority children;Mission;Modeling;Morals;Mothers;National Institute of Child Health and Human Development;neglect;Outcome;Paper;Parents;Personal Satisfaction;Persons;Phase;physically handicapped;Population;Poverty;preadolescence;prevent;preventive intervention;programs;psychologic;Publishing;Questionnaires;Reporting;Reproducibility;Research;Research Personnel;Sampling;Seminal;skills;social norm;stem;Stress;Study models;Testing;Time;Training;Woman;Work

PROJECT_TITLE: Parental psychological control in Mexican immigrant families: A culturally sensitive measure and mechanism

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Harm Reduction for Substance Misuse;Opioid Misuse and Addiction;Opioids;Pediatric;Physical Injury - Accidents and Adverse Effects;Prevention;Stimulant Use and Misuse;Substance Misuse;Substance Misuse Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE The proposed research will utilize three levels of data (population-level student data, institutional-level policy data, institutional leader in-depth interview data) to construct the most comprehensive evidence to date of opioid overdose prevention in higher education. The long-term goal of this research is to inform the design and implementation of opioid overdose and harm reduction programs and policies for the more than 16 million college students in the U.S. The proposed research focuses on novel prevention, treatment and harm reduction approaches, while studying the implementation of evidence-based strategies for college student populations, addressing two priority scientific areas outlined in NIDA’s 2022-2026 Strategic Plan.

PI_NAMEs: FREIBOTT, CHRISTINA ELLIOTT (contact)

PROGRAM_OFFICER_NAME: MITCHELL, SHANNON GWIN

PROJECT_TERMS: Acceleration;Adderall;Address;Adolescent;Adolescent and Young Adult;Adoption;Adult;Age;age group;Area;career;Characteristics;Cocaine;college;Data;Databases;Decision Making;design;Development;ecstasy;Enrollment;Environment;Epidemiology;evidence base;Fentanyl;Future;Goals;Harm Reduction;harm reduction programs;Health;higher education;innovation;Institution;Intervention;Interview;Knowledge;large scale data;Letters;Life;Link;Measures;Medical;Methodology;Methods;Mind;Naloxone;naloxone dispensing;National Institute of Drug Abuse;non-opioid analgesic;novel;Opioid;opioid misuse;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose education;overdose prevention;Overdose reduction;Overdose reversal;overdose risk;peer;Perception;Pharmaceutical Preparations;pill;Policies;Population;Positioning Attribute;prevent;Prevention;Prevention program;programs;Public Health;public health research;Qualitative Research;Readiness;recruit;Reporting;Research;Research Personnel;Risk;Ritalin;Role;Sampling;Schools;Secondary Schools;Services;Site;Source;Stimulant;Strategic Planning;Structure;Student Health Services;Students;Subgroup;substance use;Surveys;synthetic opioid;System;therapy design;Time;Universities;university student;willingness

PROJECT_TITLE: Opioid overdose prevention in US higher education settings: a multisite, mixed methods study of college students and institutional leaders

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (21)]


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_DEPT: GENETICS

PHR: Project narrative Nuclear DNA organization is deliberate. It inﬂuences transcriptional regulation, and structural deviations are associated with cancers and congenital developmental disorders. The goal of this proposal is to elucidate the sequence determinants of 3D genome folding across human tissues and mammalian species and model the impact of genome folding on epigenetic regulation, gene expression and alternative splicing.

PI_NAMEs: JHA, ANUPAMA  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, DANIEL A

PROJECT_TERMS: 3-Dimensional;Advisory Committees;Alternative Splicing;Architecture;ATAC-seq;Base Sequence;Biochemical;Biological Assay;Biological Process;Biology;bridge program;career development;Cell Nucleus;Chromatin;Clinical;convolutional neural network;Data;deep learning model;design;developmental disease;Disease;DNA;Environment;epigenetic regulation;Evolution;explainable machine learning;Foundations;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genetic Variation;Genome;genome-wide;genomic locus;Genomics;Goals;Health;Hi-C;Human;human DNA;Human Genome;human tissue;insight;Joints;Learning;Learning Skill;learning strategy;Machine Learning;machine learning method;machine learning model;Malignant Neoplasms;Maps;Measures;Mentors;meter;Methods;Modeling;Multiomic Data;Neural Network Simulation;next generation sequencing;novel;Nuclear;Nuclear Structure;open source;Output;Phase;Positioning Attribute;Post-Transcriptional Regulation;Postdoctoral Fellow;pre-trained transformer;predictive modeling;preservation;Process;programs;Regulation;Research;Research Personnel;Research Training;Resources;RNA;Role;Scientist;Shapes;structural determinants;Tissues;tool;Training;Transcript;Transcriptional Regulation;transcriptome sequencing;transcriptomics;Translating;Translations;two-dimensional;Universities;Variant;Washington;Work

PROJECT_TITLE: Integrative models of nuclear DNA organization

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Congenital Structural Anomalies;Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Neurosciences;Pediatric;Rare Diseases;Vector-Borne Diseases;Zika Virus

ORG_CITY: DETROIT

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Zika virus (ZIKV) is the causative agent of smaller head (microcephaly) and other severe brain and eye defects in newborn. However, it is not known how ZIKV enters the eye or brain to cause the Congenital Zika Syndrome (CZS). In this study, we plan to delineate the molecular mechanisms of ZIKV induced breach of blood-retinal barrier using retina organoids and animal models.

PI_NAMEs: SINGH, SNEHA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;Adherens Junction;Advisory Committees;Affect;analog;Angiopoietin-2;Angiopoietins;Animal Model;Atrophic;Blood-Retinal Barrier;Brain;brain volume;Brazil;career development;Cell Line;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Committee Members;Congenital Abnormality;congenital zika syndrome;congenital ZIKV infection;Cre lox recombination system;CRISPR/Cas technology;Data;Defect;Dyes;E-Cadherin;Embryo;Epidemic;Evans blue stain;Eye;Flavivirus;fluorescein isothiocyanate dextran;Gene Mutation;Genetic;Glaucoma;Goals;Head;Human;Hydrophthalmos;Immunocompetent;in vivo;Individual;induced pluripotent stem cell;Infant;Infant Health;Inflammation Mediators;inhibitor;insight;Institution;Knock-out;knockout gene;Laboratories;Learning;Lentivirus;Lesion;Link;Long-Term Effects;Measures;Mediating;meetings;Mentors;Microcephaly;Modality;Modeling;Molecular;mouse model;Mus;Newborn Infant;Ocular Pathology;offspring;Optic Neuritis;Organoids;pathogen;Pathogenesis;Pathology;Pathway interactions;Permeability;pharmacologic;Phase;Positioning Attribute;post-doctoral training;Pregnancy;pregnant;Production;Proteins;Public Health;public health emergency;Publishing;Regulation;Reporting;Research;Retina;Retinal Hemorrhage;RNA Viruses;Role;Scientist;screening;Signal Pathway;Signal Transduction;sphingosine 1-phosphate;stem cells;Structure of retinal pigment epithelium;symposium;Testing;Therapeutic;Therapeutic Intervention;Tissues;transcriptome;transcriptomics;Treatment Efficacy;Universities;Vascular Endothelial Cell;Vascular Endothelial Growth Factors;Viral;viral detection;Viral Load result;Viral Physiology;Viral Proteins;viral RNA;World Health Organization;Zika Virus;ZIKV infection

PROJECT_TITLE: MECHANISMS REGULATING BREACH OF BLOOD RETINAL BARRIER UPON ZIKA VIRUS INFECTION

STUDY_SECTION_NAME: Special Emphasis Panel[ZEY1 VSN (03)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Prostate Cancer;Urologic Diseases

ORG_CITY: PULLMAN

ORG_DEPT: CHEMISTRY

ORG_NAME: WASHINGTON STATE UNIVERSITY

PHR: PROJECT NARRATIVE  While PSMA-targeting has been a successful imaging and drug-delivery strategy for various payloads to prostate tumor cells, there is a need to overcome the challenges of tumor heterogeneity and drug resistance in order to provide treatment options for metastatic castrate-resistant prostate cancer (mCRPC) patients, especially those that relapse or fail to meet the requirements for radiotherapy. A PSMA-targeted, pH- responsive small molecule dual drug conjugate that bears two different chemotherapeutic drugs with different mechanisms of action and simultaneously releases both drugs upon internalization in tumor cells is anticipated overcome these challenges. This project aims to develop a new class of PSMA-targeting agents to meet the need for efficiently and selectively treating mCRPC patients and other PSMA(+) neovasculature cancers, as well as set the foundation for a general, dual-drug strategy for targeted chemotherapy for other biomarker- characterized diseases.

PI_NAMEs: BERKMAN, CLIFFORD  (contact)

PROGRAM_OFFICER_NAME: FU, YALI

PROJECT_TERMS: Achievement;Acids;Address;Affinity;Albumins;androgen independent prostate cancer;Antigen Targeting;Binding;Biological Assay;Biological Markers;Cancer Patient;Castration;Cell Line;chemotherapy;Clinical;clinically relevant;combat;Companions;cytotoxic;design;Development;Disease;Drug Combinations;Drug Delivery Systems;drug release kinetics;Drug resistance;Effectiveness;Endosomes;Endothelium;Enzymes;Epithelium;Exatecan;Exhibits;Face;Fluorescent Dyes;FOLH1 gene;Foundations;Future;Goals;Image;imaging agent;improved;In Vitro;inhibitor;innovation;Kidney;Kinetics;Lacrimal gland structure;Ligands;LNCaP;Location;Lysosomes;Malignant neoplasm of prostate;Malignant Neoplasms;men;Metastatic Prostate Cancer;mouse model;nanomedicine;Neoplasm Metastasis;neoplastic cell;neovasculature;next generation;novel;Organ;Outcome;Patients;PC3 cell line;Pharmaceutical Preparations;phosphoramidate;Physiological;Plasma;Positron-Emission Tomography;pre-clinical;Primary Neoplasm;Property;prostate cancer cell;prostate cancer cell line;Prostatic;Quality of life;Radiation therapy;Relapse;Reporting;Resistance;Rhodamine;Salivary Glands;Site;small molecule;spatiotemporal;Structure of base of prostate;System;targeted agent;targeted imaging;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Treatment Efficacy;tumor;tumor heterogeneity;uptake;Work

PROJECT_TITLE: Tumor-Activated Dual Payload-Drug Conjugates

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-2 (M3)]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Immunotherapy;Precision Medicine;Women's Health Research

PHR: PROJECT NARRATIVE Despite recognized intertumoral diversity, current treatment strategies for triple negative breast cancer remain generalized due to lack of reliable biomarkers. This proposal seeks to quantitatively characterize TNBC heterogeneity using novel habitat signatures and elucidate interpatient differences to aid in stratifying patients with increased probability of response to neoadjuvant therapy. Successful whole-tumor habitat characterizations will yield greater understanding of an individual’s tumor physiology and provide an avenue to further personalize breast cancer care.

PI_NAMEs: KAZEROUNI, ANUM SYED (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: advanced disease;Adverse effects;Affect;aggressive breast cancer;anatomic imaging;anti-cancer research;Area;Award;Biological;Biological Markers;Biology;Biopsy;Biopsy Specimen;Blood Vessels;Breast Cancer Model;Breast Cancer Patient;Breast Cancer Treatment;breast imaging;Breast Magnetic Resonance Imaging;cancer care;Cancer Center;cancer heterogeneity;cancer imaging;cancer subtypes;career;career development;Cells;Cellularity;chemotherapy;Clinical;clinical practice;clinical translation;Computer Analysis;Data;Dedications;Development Plans;Diagnostic;Discipline of Nuclear Medicine;Disease;Disease-Free Survival;Drug Delivery Systems;drug efficacy;Educational workshop;Emerging Technologies;Ensure;Environment;experience;Financial cost;financial toxicity;fluorodeoxyglucose positron emission tomography;Functional Imaging;Funding;Genotype;Glucose;glucose uptake;Goals;Habitats;Heterogeneity;Histopathology;Hybrids;Image;Imaging Techniques;Immunohistochemistry;Immunotherapy;improved;In complete remission;in vivo;Individual;Informatics;innovation;Institution;Lesion;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Measurement;Measures;Medical Oncology;meetings;Mentors;Mentorship;Metabolic;Metabolism;Methodology;Methods;molecular imaging;Molecular Target;mouse model;Neoadjuvant Therapy;novel;Operative Surgical Procedures;Oxygen;Pathologic;Pathology;patient population;patient stratification;Patient-Focused Outcomes;Patients;personalized medicine;Phase;Phenotype;Physiological;Physiology;Positron-Emission Tomography;Prediction of Response to Therapy;Probability;prospective;quantitative imaging;Radiology Specialty;Recurrence;Research;Research Personnel;Research Proposals;response;Risk;Selection for Treatments;Stratification;Techniques;Testing;Therapeutic;Time;Tissues;Training;Training and Education;Training Programs;Translating;Translations;Treatment outcome;Treatment Protocols;treatment response;treatment strategy;triple-negative invasive breast carcinoma;tumor;Tumor Burden;tumor heterogeneity;tumor microenvironment;Tumor Volume;tumor-immune system interactions;Tumor-Infiltrating Lymphocytes;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Quantitative characterization of tumor heterogeneity using habitat imaging for the prediction of patient outcome in triple negative breast cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Lung;Pulmonary Fibrosis;Rare Diseases

PHR: PROJECT NARRATIVE  Idiopathic pulmonary fibrosis (IPF) is a progressive and often fatal disease with significant variations in individual clinical courses and poorly understood underlying mechanisms. Accumulating evidence shows that abnormalities in the pulmonary endothelium precede tissue fibrosis, therefore accurate assessment of the physiological and microvascular changes in IPF s crucial for gaining a deeper understanding of the disease's pathophysiology, which is valuable for improving patient care and facilitating drug development for this deadly disease. This project aims to establish a pharmacokinetic model for absolute quantification of pulmonary perfusion and microvascular parameters and validate this model in large animal models with independent tissue analyses of perfusion and vascular permeability.

PI_NAMEs: ZHOU, IRIS YUWEN  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Air;analytical tool;Animal Model;Animals;Asthma;Award;Bleomycin;Blood;blood fractionation;blood perfusion;Blood Vessels;Blood Volume;Bolus Infusion;brain tissue;chest computed tomography;Chronic Obstructive Pulmonary Disease;Clinical;contrast enhanced;Contrast Media;Data;Dependence;Deposition;Detection;Development;Disease;Dose;drug development;Dyes;Endothelium;Evans blue stain;Event;extracellular;Extracellular Matrix;Extravasation;Family suidae;FDA approved;ferumoxytol;Fibroblasts;Fibrosis;fibrotic lung;Functional disorder;Functional impairment;Gadolinium;Goals;healthy volunteer;Human;human data;human disease;idiopathic pulmonary fibrosis;Imaging Techniques;Impairment;improved;in vivo;Individual;Injections;insight;Intravenous;kinetic model;Kinetics;Lung;Lung Diseases;Magnetic Resonance Imaging;Measurement;Measures;Methods;Microspheres;Modeling;models and simulation;Organ;Output;Pathogenicity;Pathologic;Patient Care;Patients;Perfusion;Permeability;pharmacokinetic model;physiologic model;Physiological;porcine model;post SARS-CoV-2 infection;post-COVID-19;Progressive Disease;Property;Pulmonary Fibrosis;pulmonary function;Pulmonary function tests;Signal Transduction;Site;Specificity;Stable Disease;Standard Model;Structure of parenchyma of lung;Therapeutic;Time;Tissues;tool;Translating;Variant;Vascular Permeabilities;Water;X-Ray Computed Tomography

PROJECT_TITLE: Quantitative magnetic resonance imaging of pulmonaryperfusion

STUDY_SECTION_NAME: Special Emphasis Panel[ZHL1 CSR-N (M1)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative This work seeks to develop a new model to study amyloid-β oligomers, which hypothesized to be one of the toxic species leading to neurodegeneration in Alzheimer's Disease. Using this model, we seek to uncover the molecular factors that influence oligomer formation and to identify agents that can bind to and detect oligomers with high affinity and selectivity over other amyloid-β species. 1

PI_NAMEs: WANG, TINA  (contact)

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta oligomer;Affect;Affinity;Alzheimer's Disease;Amino Acid Sequence;Amino Acid Substitution;Amyloid beta-42;Amyloid beta-Protein;Behavior;Binding;Biochemical;biophysical properties;biophysical techniques;Biophysics;design;Development;Diagnostic;Disease;Engineering;Event;Gold;high throughput screening;inhibitor;insight;interest;Maps;Measurement;Measures;Methods;Modeling;Molecular;Mutation;mutation screening;nanobodies;Nature;Nerve Degeneration;Neurodegenerative Disorders;neurotoxic;Persons;prevent;Reporter Genes;Reproducibility;Research;response;sensor;Structure;synthetic biology;targeted treatment;Techniques;Technology;Therapeutic;Time;transcription factor;Work

PROJECT_TITLE: A high-throughput assay to measure amyloid-β oligomer formation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;HIV/AIDS;Immunization;Infectious Diseases;Lung;Orphan Drug;Prevention;Rare Diseases;Tuberculosis;Tuberculosis Vaccine;Vaccine Related

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Mycobacterium tuberculosis (Mtb)- the causative agent of tuberculosis (TB)- establishes infection in the lungs by surviving in macrophages, even in the face of a robust adaptive immune response. CD4 T cells enhance the ability of macrophages to clear Mtb, although exactly how they contribute to host control of Mtb, and why they often fail to generate sterilizing immunity, is not well understood. We will investigate mechanisms of protection conferred by macrophage-T cell interactions, elucidate the dynamics of macrophage-T cell interactions in vivo, and study how these can be enhanced. These findings could lead to novel therapies and vaccines for TB.

PI_NAMEs: PHILIPS, JENNIFER A (contact)

PROGRAM_OFFICER_NAME: RADKE, JOSHUA BRYAN

PROJECT_TERMS: adaptive immune response;Adoptive Transfer;Agonist;Alveolar Macrophages;Antigen Presentation;antimicrobial;Autophagocytosis;Bacille Calmette-Guerin vaccination;Bacteria;Binding;Biological Assay;CD4 Positive T Lymphocytes;Cell Communication;Cell surface;cell type;Cells;Coculture Techniques;conditional knockout;cytokine;Data;Development;Effectiveness;Event;experience;experimental study;Family;Generations;Goals;Hematopoietic;Human;Immune response;Immunity;immunopathology;Impairment;improved;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;intercellular communication;Interferon Type II;Interferons;interstitial;Knockout Mice;Knowledge;Location;Lung;Macrophage;Mediating;member;Membrane;Modeling;monocyte;Mus;mutant;Mycobacterium tuberculosis;Myelogenous;Myeloid Cells;NADPH Oxidase;neutrophil;nonhuman primate;novel;novel therapeutics;novel vaccines;Oxygen;Pathway interactions;Peripheral;Phagocytosis;Production;Proliferating;Reactive Oxygen Species;receptor;recruit;Regulatory T-Lymphocyte;Reporter;Resolution;response;Role;Signal Transduction;single-cell RNA sequencing;Site;SLAM protein;small molecule;Specificity;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Time;Training;Tuberculosis;tuberculosis immunity;tuberculosis treatment;Tuberculosis Vaccines;Vaccines;Virulence Factors

PROJECT_TITLE: Understanding early macrophage-T cell interactions, SLAMF1, and immunity to TB

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 RCU-A (M1)]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: PATHOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

PHR: Project Narrative Breast cancer is a leading cause of cancer deaths in women largely due to metastasis. We identified an increased association of a novel chemokine ligand CCL24 with a poor prognosis in breast cancer patients. Therefore, we propose determining the clinical significance, oncogenic function, and therapeutic targeting of CCL24 in breast cancer.

PI_NAMEs: KARAN, DEV  (contact);RUI, HALLGEIR

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: aggressive breast cancer;Biological Assay;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;breast cancer progression;cancer cell;Cancer cell line;Cancer Etiology;cancer immunobiology;CCL24 gene;cell motility;Cell Proliferation;Cells;chemokine;Chemotactic Factors;clinically significant;Data;Development;E-Cadherin;epithelial to mesenchymal transition;Estrogen receptor negative;gene function;Genetic;Goals;Health;Human;Immune;immune cell infiltrate;Immunocompetent;Immunosuppression;Immunosuppressive Agents;In Vitro;in vivo;Infiltration;innovation;Interleukin-6;Invaded;knock-down;Knock-out;Leucocytic infiltrate;Leukocyte Trafficking;Ligands;Malignant Breast Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of prostate;Malignant Neoplasms;Mammary Neoplasms;MCF10A cells;MCF7 cell;MDA MB 231;Mediating;Messenger RNA;Molecular;mouse model;N-Cadherin;Neoplasm Metastasis;Non-Malignant;novel;novel therapeutic intervention;Oncogenic;overexpression;Patients;pharmacologic;pre-clinical;Prognosis;Progression-Free Survivals;promoter;Proteins;recruit;Regulation;Research;Role;Site;Small Interfering RNA;Specimen;Suppressor-Effector T-Lymphocytes;T-Lymphocyte;T47D;Therapeutic;therapeutic target;trafficking;transcriptome sequencing;tumor;Tumor Immunity;tumor microenvironment;tumor progression;Tumor-associated macrophages;Unfavorable Clinical Outcome;United States;Woman;Women's mortality

PROJECT_TITLE: Novel chemokine in the regulation of breast cancer metastasis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-A (M1)]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Clinical Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Artificial light at night (ALAN) is an emerging environmental hazard with important public health implications, however, there is a contentious debate about how well satellite data commonly used in epidemiological studies can serve as a measure of ALAN exposure at the individual level. Our study will be the first large-scale validation effort of satellite-based ALAN measures in a nationally representative and diverse dataset with relevant health outcomes. We expect our study to provide crucial information for better interpreting existing epidemiological evidence, guiding the design of future studies, and enhancing the translational value of ALAN research.

PI_NAMEs: XIAO, QIAN  (contact)

PROGRAM_OFFICER_NAME: CUI, YUXIA

PROJECT_TERMS: access restrictions;Address;Artificial Satellites;Basic Science;Biological Markers;cardiometabolism;Characteristics;Clinical Research;Data;Data Set;Data Sources;design;Disease;diverse data;Ensure;Environmental Hazards;Epidemiology;epidemiology study;Exposure to;Foundations;Future;Geographic Locations;Geography;Health;Hour;Imagery;Individual;innovation;Life Style;Light;Link;Measurement;Measures;Methods;Monitor;National Health and Nutrition Examination Survey;Occupational;Outcome;Participant;Population;Population Characteristics;Population Study;Public Health;public health research;Publishing;Reporting;Research;Risk Factors;Sample Size;Sampling;Sampling Studies;sociodemographics;socioeconomics;Subgroup;United States National Center for Health Statistics;Validation;validation studies;Work;Wrist

PROJECT_TITLE: A Validation Study of Satellite-based Measure of Artificial Light at Night for its Application in Epidemiological Research

STUDY_SECTION: SEDH

STUDY_SECTION_NAME: Social and Environmental Determinants of Health Study Section[SEDH]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Hematology;Orphan Drug;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE  This research addresses a critical barrier to immune thrombotic thrombocytopenic purpura (iTTP) clinical trial readiness – the absence of validity evidence for clinical outcome assessments (COAs) measuring cognitive function. Without validity evidence for COAs, iTTP clinical trials cannot follow FDA patient-focused drug development guidance to evaluate the effect of candidate therapies on cognitive function – the health-related quality of life outcome most important to patients. By developing a measurement strategy for cognitive function in patients with iTTP, this research will facilitate the design and conduct of future studies using COAs as clinical trial endpoints.

PI_NAMEs: COLES, THERESA ;ONWUEMENE, OLUWATOYOSI ADEFUNKE (contact)

PROGRAM_OFFICER_NAME: CHEN, ALICE

PROJECT_TERMS: Acute;Address;Affect;Agreement;Attention;Behavior;Caregivers;Classification;clinical outcome assessment;Clinical Research;clinical trial readiness;Clinical Trials;Clinical Trials Network;Cognitive;cognitive function;Consensus;cost;Death Rate;design;Disease;Disease remission;drug development;early phase clinical trial;economic impact;Ensure;Event;experience;Future;Goals;health related quality of life;Hematological Disease;Hematology;Human;Immune;immune function;Impaired cognition;Impairment;improved;Industry;innovation;Institution;Interview;lens;Measurement;Measures;meetings;member;Memory;Methods;Minority;Modeling;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;Multicenter Studies;National Center for Advancing Translational Sciences;National Clinical Trials Network;Neurogenic Communication Disorders;novel therapeutics;Outcome;Outcome Measure;Participant;patient oriented;Patient Outcomes Assessments;Patient Self-Report;patient stratification;Patient-Focused Outcomes;Patients;Prevalence;processing speed;Psychometrics;Public Domains;Rare Diseases;Recommendation;recruit;Reporter;Reporting;Research;Resources;response;Review Literature;Site;Study models;success;survivorship;Syndrome;therapeutic candidate;Thrombotic Thrombocytopenic Purpura;Time;Translating;Voting;Woman;Work

PROJECT_TITLE: A Clinical Trial Readiness Study of Patient Reported Outcome Measures in Thrombotic Thrombocytopenic Purpura (TTP)

STUDY_SECTION_NAME: Special Emphasis Panel[ZTR1 RD-3 (02)]


NIH_SPENDING_CATS: Contraception/Reproduction;Immunization;Maternal Health;Pediatric;Pregnancy;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE A detailed understanding of B cell and antibody responses to placental versus foreign antigen will illuminate how dysregulated responses contribute to pregnancy complications and inform the design of vaccine programs which best protect mothers and children from infection. We propose to study B cell and antibody responses to placental versus foreign antigen. Results will identify molecular mechanisms suppressing B cell activation; map tolerance pathways that protect the conceptus from antibody-mediated damage; and identify a pregnancy factor capable of boosting humoral immunity, which will be clinically useful to boost responses to vaccines and fight infections.

PI_NAMEs: RIZZUTO, GABRIELLE A (contact)

PROJECT_TERMS: Affect;Alloantigen;Antibodies;Antibody Response;Antigens;B-Cell Activation;B-Lymphocytes;Cell surface;Cells;Child;Chronic;Clinical;Complement;Complement 3;Conceptus;cytotoxicity;Data;Disease;Estradiol;experimental study;fighting;Genetic Transcription;Health;healthy pregnancy;Helper-Inducer T-Lymphocyte;Humoral Immunities;Immunity;Immunoglobulin G;In Vitro;in vivo;Infection;insight;Lead;Literature;Lymphocytic choriomeningitis virus;Maps;Measures;Mediating;Methods;Modification;Molecular;Mothers;Mus;Mutation;Nature;neonatal outcome;Partner in relationship;pathogen;Phase;Placenta;Polysaccharides;post pregnancy;Postpartum Period;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;preservation;Progesterone;programs;protective pathway;Publishing;receptor;Resolution;response;restraint;reverse tolerance;Sialic Acids;Signal Transduction;Sugar Acids;Testing;Textbooks;TNFSF5 gene;transcriptomics;Vaccinated;Vaccination;Vaccine Design;Vaccines;Work

PROJECT_TITLE: Maternal B cells in health and disease.


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Lung;Nutrition;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PUBLIC HEALTH RELEVANCE STATEMENT Over one million people each year lose the ability to breathe on their own and are treated by placing a breathing tube in their throat. After regaining their ability to breathe, as many as 44% of patients may have trouble swallowing their food and liquids, and these swallowing problems are especially common in the elderly. For those patients with documented airway swelling after the breathing tube is removed, we propose to conduct a clinical trial to determine whether corticosteroids improve their ability to swallow.

PI_NAMEs: MOSS, MARC  (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: Acute respiratory failure;Admission activity;Adrenal Cortex Hormones;Adult;Age;Aging;aging population;aspirate;Boston;Breathing;Caregiver Burden;Cessation of life;Clinical Trials;cohort;Colorado;Consent;cost;Deglutition;Deglutition Disorders;Diet;Diet Modification;dietary;Dietary intake;Disease;Dose;Dyes;Edema;Elderly;endotracheal;Enrollment;Enteral;Enteral Feeding;experience;feeding;Food;Functional disorder;Health;Health care facility;Hospital Mortality;Hospitalization;Hospitals;Hour;human old age (65+);improved;improved outcome;Incidence;Individual;Inflammatory;Infrastructure;Injury;Interdisciplinary Study;interest;Intravenous;Intubation;Journals;Language;Laryngeal Edema;Larynx;Liquid substance;Long-Term Care;Mechanical ventilation;Medicine;Meta-Analysis;Modality;Mosses;Mucous Membrane;Multicenter Studies;multidisciplinary;New England;Operative Surgical Procedures;Oral;Outcome;Participant;Pathologist;patient subsets;Patients;personalized medicine;Persons;Pharmaceutical Preparations;Pharyngeal structure;Placebos;Pneumonia;Population;Predisposition;primary outcome;Procedures;Protocols documentation;public health relevance;Quality of life;Randomized;randomized trial;randomized, clinical trials;Regimen;Research;Research Infrastructure;Research Personnel;Risk;Speech;Structure;Survivors;Swelling;Texture;Time;Tube;United States;Universities;Work

PROJECT_TITLE: Randomized Trial of Corticosteroids for Post-Extubation Aspiration

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


ED_INST_TYPE: SCHOOLS OF OPTOMETRY/OPHT TECH

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Pediatric

ORG_CITY: BIRMINGHAM

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Identifying effective strategies to control myopia (nearsightedness) is a global priority to prevent the growing global public health burden of visual impairment and blindness due to myopia and myopia-related complications. Exposure to different wavelengths of light produces powerful effects on the refractive state of the eyes in animals, suggesting a critical role of wavelength cues in guiding eye growth and refractive development. This pilot, “proof of concept” project aims to determine if brief daily periods of amber light exposure can be translated from animal studies as a potential anti-myopia strategy leading to an entirely new avenue for controlling childhood myopia, in addition to providing a strong foundation for designing future, more effective myopia control technologies.

PI_NAMEs: KHANAL, SAFAL  (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: absorption;Adolescent;Adult;Affect;Age;aged;Amber;Animals;Blindness;Cavia;Chick;Child;Childhood;clinical translation;comparative efficacy;Cone;Contact Lenses;contrast imaging;Cues;Data;design;Development;disorder of macula of retina;Distant;Effectiveness;efficacy evaluation;emmetropization;Exposure to;Eye;Failure;Far East;FDA approved;Foundations;Future;Glass;Growth;Habitats;high reward;Hour;Human;human model;Hydrophilic Contact Lenses;Hyperopia;innovation;Intervention;late life;Length;lens;lens induction;Life;Light;Lighting;Macaca;Mammals;Measures;Methods;Modeling;Monkeys;Mus;Myopia;novel;Ocular Pathology;Operative Surgical Procedures;Optical Methods;Outcome;palliative;Pattern;Performance;Peripheral;Persons;Pilot Projects;pilot test;Population;pre-clinical;prevent;Primates;Public Health;Publishing;Pupil;randomized placebo-controlled clinical trial;recruit;Refractive Errors;Rest;restraint;Retina;Retinal Detachment;Risk;Risk Factors;Role;Signal Transduction;Solid;Sports;Stimulus;Technology;Testing;Thick;Time;Translating;transmission process;Tupaiidae;ultraviolet;Vision;Visual;Visual Acuity;Visual impairment

PROJECT_TITLE: Pilot test of a novel wavelength-based method to control childhood myopia

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Genetics;Human Genome;Neurodegenerative;Neurosciences;Pediatric;Rare Diseases;Spinal Muscular Atrophy

ORG_CITY: BALTIMORE

ORG_DEPT: NEUROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Spinal muscular atrophy (SMA) is a genetic, neuromuscular disease that causes early onset, severe muscle weakness. While SMA patient outcomes have significantly improved since the development of SMN- increasing therapeutics, neuromuscular deficits are still present in most patients. The objective of this project is to identify mechanisms of SMA motor neuron maldevelopment and degeneration in mouse models with differing disease severity to guide future therapeutic development and improve patient quality of life.

PI_NAMEs: MOLOTSKY, ELANA  (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Adult;Age;Automobile Driving;Autopsy;Axon;axon guidance;Behavior assessment;Behavioral;Cause of Death;cell motility;Cell Nucleus;cell type;Childhood;Choline O-Acetyltransferase;cholinergic neuron;Collaborations;Data;design;Development;Disease;disease heterogeneity;early onset;Embryonic Development;env Gene Products;Environment;Evaluation;Event;experimental study;Failure;Fluorescence-Activated Cell Sorting;Fluorescent in Situ Hybridization;Future;gain of function;Gene Expression Profile;Genes;Genetic;Goals;Green Fluorescent Proteins;Growth;Heterogeneity;Histologic;Human;human tissue;Immunohistochemistry;Impairment;improved;In Situ Hybridization;in utero;in vitro Model;in vivo;Infant Mortality;Inherited;interest;Internal Ribosome Entry Site;Label;Laboratories;Light;loss of function;Measurement;Modeling;Molecular;Motor;motor behavior;motor neuron development;Motor Neuron Disease;motor neuron function;Motor Neurons;mouse model;Mus;Muscle Weakness;Neonatal;Nerve Degeneration;neurofilament;Neurologic Deficit;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;Neurons;novel;novel strategies;Nuclear Envelope;Pathogenesis;Pathologic;Pathology;Pathway interactions;patient derived induced pluripotent stem cells;Patient-Focused Outcomes;Patients;Population;postnatal;Progressive Disease;Proteins;Publishing;Quality of life;Quantitative Reverse Transcriptase PCR;Radial;Research;Resistance;Serum;Severity of illness;single molecule;single nucleus RNA-sequencing;SMN deficiency;SMN2 gene;Sorting;Specificity;Spinal;Spinal Cord;Spinal Muscular Atrophy;Therapeutic;therapeutic development;therapeutic target;Time;Tissues;Transcript;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Ventral Roots;Weight Gain;Werdnig-Hoffmann Disease;Western Blotting

PROJECT_TITLE: Identifying Developmental and Degenerative Mechanisms of SMA Using Single Motor Neuron Nucleus RNA Sequencing

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-4 Study Section [NST-4]


NIH_SPENDING_CATS: Autoimmune Disease;Immunotherapy

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative Aberrant adaptive immune responses result in the generation of autoantibodies and development of rheumatological disease. This research will explore the role of thymic B cells in preventing autoantibody response during thymic education.

PI_NAMEs: MARTINEZ, RYAN J (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;adaptive immune response;Antibody Affinity;Antigen Presentation;Antigens;Autoantibodies;Autoantigens;Autoimmune Diseases;Autoimmunity;Award;B-Cell Activation;B-Lymphocytes;Biology;BLR1 gene;career;CCL20 gene;CCR6 gene;CD4 Positive T Lymphocytes;Cells;central tolerance;chemokine receptor;Clinical;clinical diagnosis;Clonal Deletion;Collaborations;congenital immunodeficiency;Data;Development;Diagnosis;Diagnostic;Disease;Education;experimental study;Foundations;Funding;Future;Generations;Goals;Helper-Inducer T-Lymphocyte;Humoral Immunities;humoral immunity deficiency;imaging approach;Imaging Techniques;immune activation;Immune response;Immune Tolerance;Immunization;immunodeficiency;Immunoglobulin Class Switching;Immunoglobulin Somatic Hypermutation;Immunoglobulin Switch Recombination;improved;instructor;Interferons;Laboratories;Lead;Licensing;Ligands;Location;Mediating;Medicine;Mentors;Modeling;Molecular;molecular pathology;multiplexed imaging;Mus;Mutate;old mice;pathogenic autoantibodies;Pathogenicity;Pathology;Pathway interactions;Patients;Peptides;Peripheral;Phenotype;Play;prevent;Process;programs;Receptor Cell;Regulatory T-Lymphocyte;Reporter;Research;Research Personnel;response;Rheumatism;Rheumatoid Arthritis;Risk Reduction;Role;Self Tolerance;Signal Transduction;skills;Structure of germinal center of lymph node;Systemic Lupus Erythematosus;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Therapeutic;Thymic epithelial cell;thymocyte;Thymocyte Selection;Thymus Gland;TNFRSF5 gene;TNFSF5 gene;Training;Work

PROJECT_TITLE: Role of thymic B cells in immune tolerance

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: PROJECT NARRATIVE Per- and polyfluoroalkyl substances (PFASs) are highly stable and toxic chemicals that can cause adverse human health effects (e.g. increased risk of Type 2 diabetes and liver cancer). The goal of this proposal is to develop a treatment system that combines nanotechnology with microbial degradation to achieve complete destruction of PFASs without the production of toxic byproducts. The fundamental knowledge obtained from this study will provide critical information needed in developing efficient strategies to eliminate deleterious effects of PFAS in the environment.

PI_NAMEs: AGA, DIANA S (contact)

PROGRAM_OFFICER_NAME: HENRY, HEATHER F

PROJECT_TERMS: Acids;Aftercare;Amino Acids;Bacteria;Binding;bioaccumulation;Biocompatible Materials;Biodegradation;Bioremediations;Blood;Carbon;catalyst;Characteristics;chemical association;Chemicals;Chromatography;Communities;consumer product;Couples;Degradation Pathway;dehalogenation;design;Development;Docking;drinking water;efficacy evaluation;efficacy testing;Environment;Environmental Pollution;Enzyme Interaction;Enzymes;Equilibrium;Evolution;Excision;exposed human population;Exposure to;Fluorine;Genes;Genetic Transcription;Goals;graphene;ground water;halogenation;Hazardous Chemicals;Health;Human;Hybrids;Hydrogen Peroxide;improved;in silico;individualized medicine;Industrialization;innovation;insight;Ions;Iron;Kidney;Kinetics;Knowledge;Length;Link;Liquid Chromatography;liver injury;Malignant neoplasm of liver;Malignant Neoplasms;Mass Spectrum Analysis;Measurable;Measures;Metagenomics;metallicity;Metals;microbial;microbial community;microbial genome;Microbiology;microbiota;microorganism;mineralization;Modeling;Molecular;molecular dynamics;molecular modeling;nano;nanomaterials;Nanotechnology;Natural Substance;NMR Spectroscopy;Non-Insulin-Dependent Diabetes Mellitus;novel;Outcome;oxidation;Oxidation-Reduction;Oxides;Pathway interactions;Persons;Plants;Poison;Poly-fluoroalkyl substances;prevent;Production;Property;Public Health;Reaction;remediation;Research;Resolution;Risk;rRNA Genes;Site;Site-Directed Mutagenesis;Source;Structure;Surface;System;Techniques;Technology;Testing;titanium dioxide;tool;Toxic effect;Toxicokinetics;Training;transcriptomics;Treatment Step;ultraviolet irradiation;Validation;Work

PROJECT_TITLE: Model-aided Design and Integration of Functionalized Hybrid Nanomaterials for Enhanced Bioremediation of Per-and Polyfluoroalkyl Substances (PFASs)


ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

PHR: Project Narrative Marginal zone lymphomas are the second most common subtype of indolent non-hodgkin’s lymphomas, that are strongly dependent on the tumor microenvironment in order to grow, and lack adequate preclinical models. Recently, the impressive clinical activity of inhibitors of the phosphoinositide-3-kinase (PI3K), protein kinase B (Akt), mammalian target of rapamycin (mTOR) pathway have brought to the spotlight the role of this pathway in the pathogenesis of this disease. We propose to characterize novel mouse models, and study the effect of the PI3K/AKT/mTOR alone and in combination with the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) in the pathogenesis of this incurable lymphoma.

PI_NAMEs: YAZBECK, VICTOR  (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: 3-Phosphoinositide Dependent Protein Kinase-1;Acceleration;Address;Age Months;Apoptotic;Area;B lymphoid malignancy;B-Cell Antigen Receptor;B-Lymphocytes;BCL-2 Protein;BCL2 gene;Biology;Breast Carcinoma;CD19 gene;CD3 Antigens;CD8B1 gene;Cell Line;cell type;Cellular Morphology;Clinical;comparison control;Complex;Cre-LoxP;Data;design;Development;Disease;Drug Combinations;drug development;Drug Screening;Environment;Family;Flow Cytometry;Fluorescence-Activated Cell Sorting;FOXO1A gene;FRAP1 gene;Future;Genetically Engineered Mouse;Goals;Heterozygote;Human;human disease;human model;Immune system;Immunocompetent;Immunoglobulin M;Immunohistochemistry;immunoregulation;Immunotherapy;in vivo;Indolent;Induction of Apoptosis;inhibitor;Knock-out;Lead;lymphoid neoplasm;Lymphoma;Lymphomagenesis;Lymphoproliferative Disorders;Malignant Neoplasms;Mature B-Lymphocyte;MCL1 gene;Measurement;Measures;Mediator;Medical;microPET;Modeling;mouse model;Mus;Mutation;Myeloid-derived suppressor cells;Non-Hodgkin's Lymphoma;novel;overexpression;Pancreatic carcinoma;Pathogenesis;Pathologic;Pathway interactions;Patients;Pheochromocytoma;Phosphatidylinositols;Phosphorylation;Phosphotransferases;Play;Pre-Clinical Model;Prostate carcinoma;Proto-Oncogene Proteins c-akt;PTEN gene;PTPRC gene;rational design;Refractory;Regulatory T-Lymphocyte;Relapse;Research;response;Role;Signal Pathway;Signal Transduction;Stains;STK11 gene;System;TdT-Mediated dUTP Nick End Labeling Assay;Testing;Therapeutic;therapy design;Time;tumor;tumor microenvironment;Tumor Suppressor Genes;Western Blotting

PROJECT_TITLE: Modeling Marginal Zone Lymphomagenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-K (M1)]


NIH_SPENDING_CATS: Asthma;Biotechnology;Clinical Research;Infectious Diseases;Lung;Pediatric;Precision Medicine

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Respiratory infections are a leading cause of morbidity and mortality in children <5 years of age, but there is a gap in understanding of the biological determinants of inter-individual variability in infection risk. This proposal applies an innovative approach to derive proteomic-driven subtypes (i.e., “inflamma-types) correlated to respiratory infection risk, then biochemically characterize these inflamma-types to identify key ‘omic features contributing to risk variability and the development of subsequent diseases in high risk individuals. These findings will pave the way towards targeted therapeutics and personalized medicine approaches, ultimately to improve quality of life for children suffering from recurrent respiratory infections in early life.

PI_NAMEs: PRINCE, NICOLE  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 1 year old;10 year old;5 year old;6 year old;Address;Age;Algorithms;analytic epidemiology;Analytical Chemistry;antenatal;Asthma;atopy;Biochemical;Biochemical Pathway;Biochemistry;Biological;Biology;career;Child;Childhood;Clinical;cohort;Collaborations;Complement;Complex;Custom;Data;design;Development;Disease;Doctor of Philosophy;early childhood;Enrollment;Environment;Epidemiology;Equilibrium;experience;follow-up;Genetic;Goals;Heterogeneity;high risk;high risk population;Immune;Immune system;Immunology;improved;Individual;infancy;Infection;infection risk;Inflammatory;innovation;inter-individual variation;interest;Knowledge;Label;Life;Measures;Mediator;Medicine;Mentors;metabolome;metabolomics;Methodology;Methods;Molecular Epidemiology;Morbidity - disease rate;mortality;multiple omics;novel;novel strategies;Outcome;Pathway interactions;personalized medicine;Predisposition;Process;Proteins;Proteome;Proteomics;Quality of life;Recurrence;recurrent infection;Regression Analysis;Research;Research Design;Research Ethics;Research Personnel;respiratory;Respiratory System;Respiratory Tract Infections;response;Risk;Role;Sampling;skills;steroid hormone biosynthesis;Subgroup;success;Systems Biology;targeted treatment;Testing;Time;Training;Validation;Vitamin D

PROJECT_TITLE: Inflammatory subtypes and multi-omic determinants of early life infection risk

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Infectious Diseases;Microbiome;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Healthcare-associated infections in neonatal intensive care units lead to significant morbidity and mortality, and are often caused by antimicrobial resistant pathogens. This proposal will use metagenomic next-generation sequencing in novel ways to track pathogen transmission, identify environmental reservoirs of infection, and understand acquisition of antimicrobial resistant microbes in hospitalized neonates. Together this work leverages innovative metagenomic sequencing tools and analyses to advance infection control approaches and curb the spread of drug-resistant infections.

PI_NAMEs: CHU, VICTORIA TIEN-YU (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Address;Affect;Anterior nares;Antibiotics;antibody test;Antigens;antimicrobial;Antimicrobial Resistance;antimicrobial resistant pathogen;beta-Lactamase;beta-Lactams;Biological;California;career;career development;Childhood;clinically significant;Collaborations;Communicable Diseases;Computer Analysis;cost;Data;Development;Disease Outbreaks;Drug resistance;Early Diagnosis;Enrollment;Ensure;Environment;Epidemiology;Event;Exposure to;Foundations;Funding;fungus;Future;genome sequencing;Genomics;Goals;gut microbiome;health care settings;healthcare-associated infections;high dimensionality;Hospitalization;Hospitals;Hour;Immune system;Incidence;Infection;Infection Control;Infection prevention;infection risk;Infectious Skin Diseases;innovation;insight;Investigation;Knowledge;late onset sepsis;Lead;Length of Stay;Medicine;Mentored Patient-Oriented Research Career Development Award;Mentorship;metagenomic sequencing;Metagenomics;Methods;Microbe;microbial;microbiome;microorganism;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;Multicenter Studies;multidisciplinary;nasal microbiome;Nasopharynx;Neonatal;Neonatal Intensive Care Units;neonate;next generation sequencing;Nose;Nosocomial Infections;novel;novel strategies;Organism;pathogen;Pathogen detection;pathogenic bacteria;pathogenic microbe;pathogenic virus;patient oriented research;Patients;Patients' Rooms;Physicians;Pneumonia;Predisposition;preventable death;Prevention program;preventive intervention;prospective;Prospective cohort;Public Health;Research;Research Design;Resistance;resistance gene;Resistance to infection;resistome;respiratory virus;Sampling;San Francisco;Scientist;screening;Sepsis;Skin;skin microbiome;Soft Tissue Infections;standard of care;success;Surface;Surgical Wound Infection;Swab;Symptoms;Taxonomy;Techniques;Technology;Time;tool;Training;transmission process;Universities;Viral;viral transmission;Virus;whole genome;Work

PROJECT_TITLE: Metagenomic surveillance of pathogen and antimicrobial resistance gene transmission in hospitalized neonates

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Cost Effectiveness Research;Health Services;Mental Health

ORG_CITY: BELMONT

ORG_NAME: MCLEAN HOSPITAL

PHR: PROJECT NARRATIVE. Without addressing problems in outcome-focused quality measures, policymakers, researchers, and clinicians are limited in their ability to detect the impact of mental health on society and the efficacy of interventions intended to ameliorate this impact. To address these problems, we propose a creative new approach to measuring quality of life that can serve as a more accurate and generalizable outcome-focused quality measure. As a result, the proposed research is relevant to public health because it eliminates a critical bottleneck to efforts by policy makers, researchers, and clinicians who are looking to improve mental health outcomes.

PI_NAMEs: DE NADAI, ALESSANDRO STEVENS (contact)

PROGRAM_OFFICER_NAME: HUMENSKY, JENNIFER L

PROJECT_TERMS: Address;Back;Caring;Characteristics;Clinical;clinical practice;comparative effectiveness;Cost effectiveness research;Creativeness;Development;Diabetes Mellitus;Disease;experience;Feedback;Foundations;Goals;Healthcare Systems;improved;Individual;individual patient;innovation;Intervention;Leadership;Measurement;Measures;Mental Depression;Mental Health;Mental Health Services;Methodology;Modeling;novel strategies;Outcome;Outcome Measure;Patients;Persons;phenomenological models;physical conditioning;Policy Maker;Population;Procedures;Process;Provider;Public Health;Quality of life;Quality of Life Assessment;Recommendation;Research;Research Personnel;Resource Allocation;Resources;Schizophrenia;Societies;Subgroup;Symptoms;Third-Party Payer;Translating;Treatment Efficacy;unsupervised learning;usability;Weight;Work

PROJECT_TITLE: Personalized Quality of Life Measurement

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (05)]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: PHILADELPHIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE The objective of the 106th Annual CASA Educational and Training Seminar is to provide a venue where field inspectors, food program managers, industry leaders and academia from across the region can personally interact and share ideas while receiving information on current and emerging food topics impacting health and safety. The conference will contribute to a more educated, informed, and integrated food regulatory community and this in turn will contribute to a safer food supply.

PI_NAMEs: SORTINO, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: WEBB, SUZANNE

PROJECT_TITLE: 106th Annual Educational and Training Seminar

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 ORA-J (01)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Mental Health;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative We are requesting funds to purchase the TissueVision TissueCyte 1600FC serial two-photon tomography microscope to enable high-throughput, high resolution automated imaging of whole rodent brains or spinal cord segments by NIMH/NIH supported investigators at UT Southwestern Medical Center in Dallas, TX. The instrument will be housed in and maintained by the Whole Brain Microscopy Facility, and will be accessible to all investigators on campus as well as external users. Health related research that will benefit from the requested instrument includes: characterization of neocortical development and cerebellar circuitry and their relationships to autism and other neurodevelopmental disorders, creation of a detailed multimodal developmental reference atlas of mouse spinal cord, evaluation of mouse models of metabolic epilepsies, mapping oligodendrocyte subpopulations during development, determination of how hippocampal hyperactivity drives circuit changes in schizophrenia, and supporting basic and disease focused characterization of the hippocampal-entorhinal memory system.

PI_NAMEs: RAMIREZ, DENISE MARIE (contact)

PROGRAM_OFFICER_NAME: LIU, CHRISTINA HUANG

PROJECT_TERMS: 3-Dimensional;9 year old;analysis pipeline;autism spectrum disorder;base;Basic Science;Brain;Brain Injuries;Client;Clinical;Complement;Custom;Data Set;Dementia;Detection;Epilepsy;Equipment;experimental study;Face;fluorophore;Funding;Generations;Image;imaging modality;Individual;innovation;instrument;Label;Laboratories;Lasers;Medical center;Mental Depression;Methods;Microscope;Microscopy;millimeter;mosaic;multiplexed imaging;National Institute of Mental Health;Neurologic;Neurological Models;neuronal circuitry;Neurons;neuropsychiatry;Neurosciences;Neurosciences Research;Organ;ratiometric;Research Personnel;Research Project Grants;Resolution;Robotics;Rodent;Sampling;Sapphire;Schizophrenia;Scientist;Signal Transduction;Slide;Spinal Cord;Spinal cord injury;Stains;System;Texas;tomography;two-photon;United States National Institutes of Health;Update

PROJECT_TITLE: Advanced Serial Two Photon Tomography System for Neuroscience Research

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-E (03)]


ED_INST_TYPE: OVERALL MEDICAL

NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE The highly elaborate morphology of astrocytes is evolutionarily conserved and tied to their many functions in the CNS, though our understanding of how this morphology is regulated is incomplete. Here, we propose to investigate how astrocyte morphology is regulated by the Sarm1-WNK-NAD+-Axed signaling axis, a canonical molecular pathway most known for its involvement in axon degeneration. By using pharmacology, genetics, and in vivo imaging in the larval zebrafish, our work will uncover new molecules crucial for astrocyte morphogenesis and provide new insights into the Sarm1 signaling pathway.

PI_NAMEs: MONK, KELLY R (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Affect;Anabolism;Astrocytes;axonal degeneration;Back;Biology;Brain;BTB/POZ Domain;Buffers;Candidate Disease Gene;cell type;Central Nervous System;clinical development;Clinical Trials;Critical Pathways;Development;Drosophila genus;Enzymes;Exhibits;extracellular;fly;Genetic;genetic manipulation;Genetic Screening;Glutamate-ammonia-ligase adenylyltransferase;Goals;Growth;Health;Human;in vivo;in vivo imaging;inhibitor;insight;knock-down;Knock-out;Maintenance;Mediating;Modeling;Molecular;Morphogenesis;Morphology;Mus;Nerve Degeneration;Nervous System;neural;Neurodegenerative Disorders;Neuroglia;Neurons;Nicotinamide adenine dinucleotide;Nicotinamide Mononucleotide;nicotinamide phosphoribosyltransferase;novel;null mutation;Orthologous Gene;Pathway interactions;Patients;pharmacologic;Pharmacology;Phase I Clinical Trials;Process;Protein-Serine-Threonine Kinases;Proteins;Regulation;reverse genetics;Role;Signal Pathway;Signal Transduction;Structure;Synapses;Synaptic Transmission;synergism;System;Vertebrates;Wallerian Degeneration;Work;Zebrafish

PROJECT_TITLE: Converging molecular mechanisms in axon degeneration and astrocyte morphogenesis

STUDY_SECTION: CMBG

STUDY_SECTION_NAME: Cellular and Molecular Biology of Glia Study Section[CMBG]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: CHARLESTON

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The proposed research will examine five existing human subjects’ datasets for a focused secondary analysis of breathing asynchrony in persons with Parkinson’s disease. Examining thoraco-abdominal asynchrony and paradoxical motion is a novel scientific approach for better elucidating the underlying respiratory changes associated with Parkinson’s disease. The study results will identify potential therapeutic targets leading to improved communication and quality of life for persons with Parkinson’s disease.

PI_NAMEs: RICHARDSON, KELLY  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Abdomen;Address;Adult;Age;Amyotrophic Lateral Sclerosis;associated symptom;Automobile Driving;Basal Ganglia;biological sex;Breathing;Cerebellar Diseases;Characteristics;Chest;Chest wall structure;Clinical;Clinical Markers;cohort;Communication;Data;Data Set;dexterity;Disease;Disease Progression;Duchenne muscular dystrophy;Dyspnea;Ensure;Exhalation;Exhibits;experience;expiration;Functional disorder;Gait abnormality;Generations;Goals;Heart Diseases;Hematological Disease;Heterogeneity;High Prevalence;human subject;Impairment;improved;Injury;innovation;Intervention;intervention effect;Investigation;kinematics;Knowledge;Length;Literature;Lung;Lung Diseases;lung volume;Measures;Mental Depression;Motion;Motor;Movement;Muscle;Muscle Fatigue;muscle strength;Muscle Weakness;Nervous System Disorder;Neurologic;novel;novel diagnostics;novel strategies;novel therapeutic intervention;Parkinson Disease;Patients;Pattern;Persons;Phase;Physiological;Population;posture instability;pressure;prevent;Production;Protocols documentation;Pulmonary function tests;Quality of life;Reporting;Research;Research Personnel;Respiration;respiratory;Respiratory Diaphragm;Respiratory Muscles;Respiratory physiology;Respiratory Signs and Symptoms;Respiratory System;response;Rest;rib bone structure;Sample Size;Sampling;secondary analysis;Severity of illness;sex;Social isolation;Speech;standardize measure;stem;strength training;success;Symptoms;System;therapeutic target;Time;Treatment Protocols;Vital capacity;vocal cord;Voice;voice therapy;Work;Work of Breathing

PROJECT_TITLE: Ribcage-abdominal movement asynchrony in persons with Parkinsons disease

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]


NIH_SPENDING_CATS: Cerebrovascular;Lymphatic Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: PROJECT NARRATIVE Traumatic spinal cord injury (SCI) is a neurologic catastrophe resulting in varying degrees of motor, sensory, and sympathetic impairment, and a robust inflammatory response is a hallmark of this disease process. CSF is able to communicate with the CNS-adjacent bone marrow to stimulate hematopoiesis and myeloid cell egress back to the CNS border meninges and perivascular spaces, but the exact mechanism underlying this signaling remains unknown. In this proposal, we will determine if CSF flow rate is able to regulate myeloid egress, whether SCI disrupts this CSF flow leading to increased myeloid cells in the CNS after injury, and if manipulation of CSF flow to the bone marrow can ultimately improve recovery after SCI.

PI_NAMEs: PLOG, BENJAMIN ARTHUR (contact)

PROJECT_TERMS: Acetazolamide;Alzheimer's Disease;Antigen Presentation;Autoimmunity;Axon;Back;Blood;Blood Vessels;Bone Marrow;Brain;cell motility;Cells;Central Nervous System Diseases;Cephalic;Cerebrospinal Fluid;cerebrospinal fluid flow;chemokine;Circulation;cisterna magna;Communication;cranium;Cues;cytokine;Diabetes Mellitus;Disease;Drainage procedure;Dura Mater;Economic Burden;Edema;Event;experimental study;Flow Cytometry;Fluid Balance;glymphatic dysfunction;glymphatic flow;glymphatic system;Hematopoiesis;Hemorrhage;human disease;Image;Immune;Immune system;Impairment;improved;Infiltration;Inflammation;Inflammatory;Inflammatory Infiltrate;Inflammatory Response;Injury;innovation;Intercellular Fluid;Intrathecal Injections;Ischemia;Lymphatic;lymphatic vessel;Macrophage;Marrow;mechanical force;Meningeal lymphatic system;Meninges;migration;monocyte;Motor;Movement;Mus;Myelin;Myelogenous;Myeloid Cells;Necrosis;Nervous System Physiology;neuroinflammation;Neurologic;neurological recovery;Neurons;neutrophil;Normal saline;novel therapeutics;Ovalbumin;Parkinson Disease;Pathologic;Pathologic Processes;Pathway interactions;Patients;Peripheral;Phase;Population;Process;Quality of life;Recovery;recruit;repaired;Role;Saline;Sensory;sham surgery;Signal Transduction;social;socioeconomics;solute;Spinal;Spinal Cord;Spinal cord injury;spine bone structure;Stroke;Testing;Therapeutic;Time;Tissues;tool;Tracer;Vocation;wasting;Wild Type Mouse

PROJECT_TITLE: Investigating the role of CSF flow in regulating CNS-adjacent bone marrow-derived myeloid cell egress after spinal cord injury


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: FORT WORTH

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Glaucoma is the leading cause of irreversible vision loss and blindness, and current glaucoma treatments do not always work, leading many glaucoma patients to continue losing their vision. We will target a new molecular pathway that we have recently discovered that damages the eye in glaucoma. If successful, our discovery will provide a novel approach for treating glaucoma to prevent the progressive damage to the eye that leads to vision loss and blindness.

PI_NAMEs: CLARK, ABBOT FREDERICK (contact);SIDEROVSKI, DAVID P.

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: 3-Dimensional;Address;Adult;Affect;Age;antagonist;Applications Grants;Aqueous Humor;Axon;Back;Binding;Binding Proteins;Binding Sites;Biological Assay;Blindness;BMP2 gene;BMP4;Bone Morphogenetic Proteins;Brain;Cell Culture Techniques;Cells;Complex;Cultured Cells;delivery vehicle;Development;Disease;Doctor of Philosophy;Dose;drug candidate;efficacy evaluation;Equilibrium;Ethnic Origin;Extracellular Matrix;Eye;Family;Fibronectins;Fibrosis;Glaucoma;in silico;In Vitro;in vivo;Individual;inhibitor;innovation;Lead;Libraries;member;Metabolism;Modeling;Molecular;molecular dynamics;mouse model;Mus;Myopia;Nerve Degeneration;Neurodegenerative Disorders;Neurons;Neurosciences;Normal tissue morphology;novel;novel strategies;Ocular Hypertension;Operative Surgical Procedures;Optic Disk;Optic Nerve;optic nerve disorder;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;pharmacologic;Pharmacologic Substance;Pharmacology;Physiologic Intraocular Pressure;Play;prevent;Prevention therapy;Primary Open Angle Glaucoma;Process;Production;protein protein interaction;Research;Research Proposals;Retinal Ganglion Cells;Risk Factors;Role;screening;Signal Pathway;Signaling Protein;small molecule;small molecule libraries;Standardization;Structural Models;Structure;Structure-Activity Relationship;Surface Plasmon Resonance;targeted treatment;Testing;Therapeutic;therapy resistant;Thermodynamics;Time;Tissues;Trabecular meshwork structure;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;Viral Vector;Vision;Visual System;Work

PROJECT_TITLE: Discovery of novel disease modifying therapy for the prevention and treatment of glaucoma


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric

ORG_DEPT: ANATOMY/CELL BIOLOGY

PHR: Project Narrative Craniofacial abnormalities are among the most common birth defects, and these conditions often hinder the physical and mental development of affected children. My project investigates the dynamic cell behaviors required for normal lip upper morphogenesis. These findings will better reveal the cellular and molecular bases of non-syndromic cleft lip and cleft lip seen in Blepharocheilodontic syndrome.

PI_NAMEs: TENG, CAMILLA SUE (contact)

PROGRAM_OFFICER_NAME: THIRUMANGALATHU, SHOBA

PROJECT_TERMS: Ablation;Actins;Actomyosin;Acute;Adherens Junction;Advisory Committees;Affect;Alleles;alpha catenin;aspirate;base;Biological Assay;Biology;Biomechanics;Cadherins;career;Cell Adhesion;cell behavior;Cell-Cell Adhesion;Cells;Cellular biology;Child;Cleft Lip;Communities;Complex;conditional mutant;Congenital Abnormality;Coupling;craniofacial;Craniofacial Abnormalities;craniofacial complex;craniofacial development;Cytoskeleton;Data;Dedications;Defect;Dependence;Development;Disease;E-Cadherin;Enrollment;Exhibits;experience;F-Actin;gene-editing approach;Genes;Genetic Transcription;Goals;Image Analysis;imaging approach;imaging modality;Individual;inhibitor;Link;lip morphogenesis;Lip structure;Live Birth;mechanical signal;mechanotransduction;mental development;Mentors;Mentorship;Microfilaments;Modeling;Molecular;Molecular Analysis;Morphogenesis;Morphology;Mus;mutant;Mutant Strains Mice;Mutation;Myosin ATPase;Nose;novel;null mutation;orofacial cleft;Phenotype;Play;post-doctoral training;Process;programs;protein function;Proteins;quantitative imaging;recruit;Regulation;Research;Role;Signal Transduction;Site;skills;spatiotemporal;Syndrome;System;Techniques;Testing;Time;Tissues;Training;Training Programs;WNT Signaling Pathway;Work

PROJECT_TITLE: Roles of p120-catenin in craniofacial development and disease

STUDY_SECTION: DSR

STUDY_SECTION_NAME: National Institute of Dental and Craniofacial Research Special Grants Review Committee[DSR]


NIH_SPENDING_CATS: Data Science;Neurosciences

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: While true for all disciplines, it is particularly important to encourage collaboration and team science in the field of neuroscience to not only offer a larger scope of perspectives and expertise, but also to result in improvements in the rigor and reproducibility of the resulting research. The educational units in this proposal aim to promote reproducible research through rigorous study design, statistical analysis planning, and data presentation within a team science framework.

PI_NAMEs: HANLON, ALEXANDRA L (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Accounting;analytical method;Area;Biomedical Research;Biometry;Clinical;Collaborations;Communication;Communities;Coordination and Collaboration;Country;Data;Data Analyses;Data Science;Data Scientist;design;Discipline;E-learning;Education;education resources;educational atmosphere;Ensure;Environment;Epidemiologist;Error Sources;Exercise;experience;Experimental Designs;Funding;Health;health data;Health Sciences;Health Technology;improved;inattention;Infrastructure;Knowledge;Literature;Measures;meetings;Methodology;Methods;National Institute of Neurological Disorders and Stroke;Neurosciences;Normalcy;Principal Investigator;Process;Production;Recording of previous events;Reporting;Reproducibility;Reproducibility of Results;Research;research data dissemination;Research Design;Research Project Grants;Research Support;Sample Size;Schools;Science;Series;sound;Statistical Data Interpretation;Statistical Methods;statistics;Time;Training;Training and Education;Virginia

PROJECT_TITLE: Ensuring Reproducible Research through Rigorous Study Design, Statistical Analysis Planning, and Data Presentation within a Team Science Framework

STUDY_SECTION_NAME: Special Emphasis Panel[ZNS1 SRB-D (28)]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Rare Diseases

PHR: Project Narrative This research proposal addresses patient-, provider, and system- level barriers in accruing adolescent and young adult (AYA) patients (ages 15-39y) to cancer clinical trials (CCTs).The major goals of this project are to further develop and implement an AYA (Alert, Young Adult Navigation, Alliance) toolkit to streamline operations, bridge the gap between pediatric and adult consortium clinical trials, and improve AYA enrollment and retention. Protected effort for the duration of the award will provide Dr. Symons with the necessary time to develop and implement the metrics and meet regularly with all of the stakeholders involved in these endeavors.

PI_NAMEs: SYMONS, HEATHER JILL (contact)

PROGRAM_OFFICER_NAME: TAWAB-AMIRI, ABDUL

PROJECT_TERMS: Abbreviations;Academic Medical Centers;Address;Adolescent and Young Adult;Adult;Age;Appointment;Area;Award;cancer care;cancer clinical trial;cancer health disparity;Cellular Phone;Childhood;Clinical;Clinical Nursing Research;Clinical Research;clinical trial enrollment;clinical trial participant;Clinical Trials;cohort;Collaborations;Comprehensive Cancer Center;Computerized Medical Record;Dedications;Diagnosis;digital communication;diversity and inclusion;Education;Eligibility Determination;Enrollment;Funding;Goals;handheld mobile device;Hematologic Neoplasms;improved;Intervention;Joints;Knowledge;Lead;Link;Malignant Neoplasms;Medical center;meetings;multidisciplinary;operation;Operations Research;Outcome;patient engagement;Patients;Physicians;programs;Provider;psychosocial;Research;Research Proposals;social media;Survivors;System;system-level barriers;Time;tool;underserved minority;United States;web site;young adult

PROJECT_TITLE: Closing the Adolescent and Young Adult Clinical Trial Enrollment Gap with an AYA (Alert, Young Adult Navigation and Alliance) Clinical Tool

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-1 (M1)]