NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Clinical Research;Dementia;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Racial and Ethnic Minority Health Research

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE For the past 25 years, we have investigated the genetic bases of familial and sporadic Alzheimer’s disease (AD) in the Caribbean Hispanics. Despite identifying many genetic variants, the function of only a fraction of the relevant genes is fully understood. In this new proposal, we intend to conduct a genetically driven, epidemiological inclusive integration of AD in Caribbean Hispanics using deep molecular phenotyping: epigenomics, transcriptomics, proteomics and metabolomics to investigate genetic variants perturb pathways leading to disease.

PI_NAMEs: MAYEUX, RICHARD P (contact);MILLER, GARY W;TOSTO, GIUSEPPE ;VARDARAJAN, BADRI N

PROGRAM_OFFICER_NAME: BENNANI-BAITI, MICHAEL

PROJECT_TERMS: Acceleration;Affect;Age;aged;Alzheimer's Disease;Autopsy;base;Biological;Biological Assay;Biological Factors;Biological Markers;biomarker development;Blood;Blood specimen;Brain;brain tissue;Caribbean Hispanic;case control;causal variant;Cerebrospinal Fluid;Cessation of life;Chemicals;Clinical;cohort;Consent;Data;Dementia;differential expression;Disease;Disease Pathway;DNA;DNA Methylation;Dominican Republic;drug discovery;Elderly;Elderly man;Elderly woman;Environment;Environmental Risk Factor;EPHA1 gene;Epidemiology;epigenomics;Evaluation of Risk Factors;Family;Family member;Frequencies;Gene Expression;Genes;Genetic;genetic analysis;Genetic Diseases;genetic epidemiology;Genetic Risk;genetic risk factor;Genetic study;genetic variant;Genome;genome wide association study;genome-wide;Genomics;Goals;Individual;insight;Investigation;Lead;Maps;Medicine;member;Metabolism;metabolomics;Methylation;methylation pattern;Minority Groups;molecular phenotype;Multiomic Data;multiple omics;Not Hispanic or Latino;Pathway interactions;Patients;Plasma;Population;pre-clinical;protein protein interaction;Proteins;proteomic signature;Proteomics;Quantitative Trait Loci;recruit;Regulatory Element;Religion;research clinical testing;Resolution;Risk;Risk Factors;Sampling;Site;SNP genotyping;Spinal Puncture;System;targeted biomarker;therapeutic development;therapeutic target;Tissue-Specific Gene Expression;Tissues;Transcript;transcriptome sequencing;transcriptomics;Variant;Whole Blood;whole genome;Work

PROJECT_TITLE: Genetic Epidemiology and Multi-Omics Analyses in Familial and Sporadic Alzheimer's Disease Among Secular Caribbean Hispanics and Religious Order

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-C(55)]


ADMINISTERING_IC: DA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Tobacco

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE Many youth purchase nicotine and cannabis vaping products from brick-and-mortar retailers (e.g., vape shops and dispensaries) which are disproportionately located in more disadvantaged neighborhoods; however, it is unknown whether density of tobacco and cannabis retailers around adolescents’ homes and schools is associated with youth vaping initiation and dependence, and whether associations are exacerbated for youth living in areas densely concentrated with both tobacco and cannabis retailers. This K01 award will use multiple existing data sources and new data from store observations to investigate the impact of the tobacco and cannabis retail environment and neighborhood disadvantage on adolescent nicotine and cannabis vaping. This work can inform regulations to prevent vaping and its harms for youth and will prepare the PI for independent R01 research that examines geospatial and regulatory determinants of youth nicotine and cannabis use.

PI_NAMEs: HARLOW, ALYSSA FITZPATRICK (contact)

PROGRAM_OFFICER_NAME: GROSSMAN, ELYSE RACHELLE

PROJECT_TERMS: addiction;Address;Adolescent;adolescent health;Age;Area;Award;California;Cannabis;Cannabis policy;Cannabis retail;career;Censuses;Characteristics;Cigarette;cohort;Cohort Studies;Data;Data Sources;Data Store;density;Dependence;deprivation;Development;Dimensions;Disadvantaged;Disease;Disparity;Education;Electronic cigarette;Environment;Epidemiologic Methods;Exposure to;falls;Foundations;Funding;Geography;Goals;Grant;high school;High School Student;Home;Income;indexing;Individual;Joints;K-Series Research Career Programs;Knowledge;Laws;Licensing;Location;marginalization;marijuana legalization;Marijuana Smoking;marijuana use;marijuana vaping;Marketing;Measures;meetings;Mentored Research Scientist Development Award;Mentors;neighborhood disadvantage;Neighborhoods;Nicotine;Nicotine Dependence;nicotine use;non-compliance;Policies;Policy Maker;Population Heterogeneity;prevent;Price;Prospective cohort;Prospective, cohort study;Public Health;public policy on tobacco;Registries;Regulation;Research;research data dissemination;Research Personnel;respiratory;Role;Sales;Schools;Science;Scientist;secondary analysis;Secure;skills;socioeconomic disadvantage;Socioeconomic Status;Source;spatial integration;Surveys;Testing;Time;Tobacco;Tobacco use;Training;vaping;vaping nicotine;Vaporizer;Variant;Work;Writing;Youth

PROJECT_TITLE: The Tobacco and Cannabis Retail Environment, Neighborhood Disadvantage, and Adolescent Vaping

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Novel drugs are in development to treat patient-specific forms of heart failure and arrhythmias and require a suitable patient specific context for testing. Through this work, we will develop an advanced tissue engineering platform, which is able to assess arrhythmias and changes in contractility in human-derived heart-like tissue structures in the dish, in order to evaluate the cardiac effectiveness of novel therapeutics.

PI_NAMEs: EFIMOV, IGOR R;MCNALLY, ELIZABETH M (contact);ROGERS, JOHN

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Address;Adopted;Adoption;Adult;Advanced Development;Animal Model;Arrhythmia;arrhythmogenic cardiomyopathy;Biological Assay;Biomedical Engineering;Blood;Calcium;Cardiac;Cardiac Myocytes;cardiac tissue engineering;Cardiology;Cardiomyopathies;Cardiovascular system;Cell Differentiation process;Cells;Clinical;clinically relevant;computerized data processing;culture plates;Cytoskeleton;data acquisition;Defect;Development;Device or Instrument Development;Devices;Digoxin;Disease;disease model;disease phenotype;Drug Screening;drug testing;Dyes;Effectiveness;Electrodes;Electronics;Electrophysiology (science);Ensure;Equipment;experience;experimental study;fabrication;flexibility;flexible electronics;FLNC gene;Genes;Genetic;Genetic Models;Genotype;graphical user interface;Heart;Heart failure;Human;human induced pluripotent stem cells;Hydrogels;Image;improved;induced pluripotent stem cell derived cardiomyocytes;inherited cardiomyopathy;instrument;Isoproterenol;Life;manufacture;Measurement;Measures;Mechanics;Membrane;Membrane Potentials;Methods;Microelectrodes;Microfabrication;Modeling;Monitor;Morbidity - disease rate;mortality;multi-electrode arrays;Mutation;Names;next generation;novel therapeutics;Output;patient derived induced pluripotent stem cells;Patients;Performance;pharmacologic;Pharmacology Study;Pharmacotherapy;Phenotype;Physiological;Positioning Attribute;precision drugs;Process;process improvement;product development;programs;prototype;Quality Control;research and development;research clinical testing;Research Personnel;response;Safety;Sarcomeres;Scientist;sensor;Shapes;skills;Skin;Sotalol;Specific qualifier value;Sterilization;Structure;Technology;Technology Assessment;technology validation;Testing;Therapeutic;therapeutic evaluation;Time;tissue culture;Tissue Engineering;Tissues;tool;two-dimensional;Urine;Validation;Verapamil;voltage;Work

PROJECT_TITLE: Optimization of electromechanical monitoring of engineered heart tissues


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

ORG_STATE: NY

PHR: PROJECT NARRATIVE Alzheimer’s disease (AD) is a degenerative brain disorder imposing an increasing societal health burden and currently presents no effective options for clinical treatment or prevention. This proposal will investigate the role of cell-type and sub-type specific noradrenergic receptors within the brain following long-term stimulation of the locus coeruleus in AD. The outcomes of this project will reveal significant biological unknowns concerning the pathogenesis and potential treatment of AD and aide in future development of novel therapeutics and neurotechnology for disease therapy.

PI_NAMEs: WELLMAN, STEVEN  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: Acceleration;Adult;Affect;aged;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Alzheimer's disease related dementia;Amyloid;Amyloid Proteins;angiogenesis;Animals;Anti-Inflammatory Agents;Applied Skills;Astrocytes;Automobile Driving;Behavior;Behavioral;Biological;Blood;Blood capillaries;Blood flow;Blood Vessels;Brain;Brain Diseases;Brain Injuries;Brain Pathology;Brain Stem;Calcium;calcium indicator;Calcium Signaling;career;Cause of Death;Cell Death;Cell Line;Cell Nucleus;Cell Physiology;cell type;Cells;Cerebrovascular Circulation;Cessation of life;Chronic;Clinical;Clinical Treatment;Cognitive deficits;cognitive performance;combat;constriction;Dementia;design;Deterioration;Development;Devices;Disease;disease model;Disease Pathway;Disease Progression;DsRed;Electrodes;Electrophysiology (science);Etiology;experimental study;Face;Foreign Bodies;Functional disorder;Future;Genes;glial activation;Goals;Halorhodopsins;Health;Histology;Homeostasis;Impaired cognition;Implant;implantation;Individual;Injury;Interruption;intravital imaging;Ischemia;Knowledge;Light;Link;locus ceruleus structure;Mediating;Mentors;Methodology;Microelectrodes;Microglia;Molecular;Morphology;multimodality;multiphoton imaging;Nerve Degeneration;Nervous System Disorder;neural;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neuroregulation;Neurosciences;neurotechnology;neurotransmission;neurovascular;noradrenergic;Norepinephrine;norepinephrine system;novel;novel therapeutics;optogenetics;Outcome;Pathogenesis;Pathology;Pattern;Penetration;Perfusion;Pericytes;Phagocytosis;Pharmaceutical Preparations;Phase;Physiological;Population;Postdoctoral Fellow;preservation;prevent;Prevention;Process;Property;receptor;Relaxation;repaired;Research;Research Project Grants;response;Rodent Model;Role;Scheme;Senile Plaques;Severities;single cell sequencing;single-cell RNA sequencing;Source;spatiotemporal;Structure;Symptoms;tau Proteins;tau-1;Techniques;Technology;Therapeutic;Therapeutic Effect;Therapeutic Intervention;therapy outcome;Time;Tissues;tool;Training;Transgenic Model;Treatment Efficacy;two photon microscopy;Vascular Diseases;vascular injury;Viral;Work

PROJECT_TITLE: Deciphering the Role of Noradrenergic Receptors during Neuromodulation in Alzheimer's Disease


ADMINISTERING_IC: TW

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Social Determinants of Health

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: This proposal is a continuation of the currently funded Research Ethics Education Program in Jordan with activities expanding to the Middle East and North Africa region with a more robust education initiative offered through a Master of Bioethics and the first online RCR training certification in Arabic. The program is transforming social norms about research ethics and building such capacity across the region. Graduates of this program will advance research and the next generation of researchers and be leaders in responsible conduct of research.

PI_NAMEs: AL-DELAIMY, WAEL K (contact);AL-ZOUBI, KAREM H

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Academia;Achievement;Address;Award;Behavioral;Bioethics;Businesses;career;Case Study;Cementation;certificate program;Certification;Chronic Disease;Clinical;Consultations;Country;Data Collection;Databases;Department chair;E-learning;Education;education research;Educational Activities;Educational process of instructing;Educational workshop;Enrollment;epidemiology study;Ethics;Ethics Committees;Extended Family;Faculty;Faith;Female;Fogarty International Center;Fostering;Funding;Generations;Goals;Government;graduate student;Grant;Health;Health Sciences;improved;Individual;Industry;Informed Consent;Institution;institutional capacity;instructor;International;Investigation;Jordan;Language;Lead;Leadership;Learning;low and middle-income countries;Master of Science;member;Methods;Middle East;Modeling;multidisciplinary;next generation;Northern Africa;Paper;Participant;Peer Review;Phase;podcast;population health;Positioning Attribute;Privacy;programs;Public Health;public health research;Publications;Publishing Peer Reviews;Qualifying;recruit;Research;Research Ethics;Research Methodology;Research Personnel;research study;Research Training;Resources;responsible research conduct;Rest;Rights;Role;Science;Services;social culture;social norm;social stigma;Students;success;symposium;Technology;Time;Training;Training and Education;Training Programs;United States National Institutes of Health;Universities;Vital capacity;webinar;Woman

PROJECT_TITLE: The Research Ethics Education Program in Jordan


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Positron emission tomography (PET) is a powerful imaging modality to visualize molecular activities in the human body. In this project, we aim to dramatically improve the imaging resolution of PET by developing a novel positron detection mechanism that will bring ultrafast coincidence time resolution (CTR) of 10ps. If successful, the 10ps CTR PET will enable dynamic PET imaging to probe human physiology, and we will investigate this possibility for neurochemistry-specific functional brain imaging.

PI_NAMEs: JEONG, DIANA  (contact)

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: 3-Dimensional;Area;arm;Biodistribution;Brain;Brain imaging;Cardiovascular Diseases;Cardiovascular system;career development;cellular imaging;Charge;Clinical;clinical imaging;Color;Contrast Media;Data;data acquisition;Detection;detection method;detector;Development;Dose;Electrons;Elements;Event;experience;experimental study;Fiber;Fiber Optics;Grant;Human;Human body;human disease;Image;image reconstruction;imaging capabilities;imaging modality;improved;Institution;instrumentation;ionization;Ionizing radiation;Label;Laboratories;Lasers;Light;Location;Malignant Neoplasms;Measures;Medical Imaging;Mentors;millisecond;Molecular;Molecular Profiling;Nervous System Disorder;neurochemistry;Neurologic;Neurosciences;Noise;novel;optical imaging;Optics;particle;Pathway interactions;Patients;Performance;Phase;Photons;Physiologic pulse;Physiology;Positioning Attribute;Positron;Positron-Emission Tomography;Postdoctoral Fellow;Process;Property;prototype;Radiation;Radioactive;Radioisotopes;real-time images;reconstruction;Refractive Indices;Research;Research Personnel;Research Proposals;Research Training;Resolution;response;Roentgen Rays;Scheme;Signal Transduction;simulation;skills;Source;standard of care;student mentoring;Students;System;Techniques;Technology;Time;tool;Training;tumor progression;Uncertainty;Validation;Variant;Visualization;Work;Writing

PROJECT_TITLE: Novel optical detection methods for ultrafast positron emission tomography (PET)


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Wound Healing and Care

ORG_CITY: DURHAM

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: RELEVANCE Our experiments will reveal how cellular behaviors and signaling in the epidermis help in coordinating the growth of the skin during embryonic development and regeneration. This holistic view of tissues could inform novel therapeutic interventions for treatment of human conditions.

PI_NAMEs: RAMKUMAR, NITYA  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Adopted;Adult;Animals;Anterior;Area;Attention;Automobile Driving;Award;Behavior;Biological Models;Biology;career;career development;cell behavior;Cell division;Cell Proliferation;Cell Shape;Cells;Cellular biology;Communication;Complex;Cornea;Corneal Abrasion;corneal regeneration;Couples;Data;Desmosomes;Development;Developmental Biology;Disease;Embryo;Embryonic Development;Ensure;Epidermis;Epithelium;Equilibrium;Etiology;experience;experimental study;Feedback;Fertilization;Genetic;Geometry;Goals;Growth;Human;human disease;Image;Imaging Techniques;Injury;juvenile animal;MAP Kinase Gene;MAPK Signaling Pathway Pathway;Measures;Mechanics;mechanotransduction;Mediating;Mentors;Modeling;Natural regeneration;novel;novel therapeutic intervention;optogenetics;Pathway interactions;Periderm;Phase;Proliferating;regenerative biology;repaired;Research;Research Personnel;Role;sensor;Shapes;Signal Pathway;Signal Transduction;skills;Skin;skin regeneration;stem cell proliferation;stem cells;Stratification;Stratified Epithelium;Stratum Basale;Surface;System;Testing;Time;tissue regeneration;Tissues;tool;Training;transcriptomics;Transgenic Organisms;Visualization;Work;Zebrafish

PROJECT_TITLE: Mechanism of epidermal coordination during development and regeneration in zebrafish

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences;Nutrition

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

PHR: PROJECT NARRATIVE The proposed research aims to understand the fundamental genetic, molecular, and cellular mechanisms that induce a “hangry” state in animals in response to food odor. Lack of a specific nutrient often dramatically changes physiology and behavior, including social behaviors, across animal species, but the underlying neuronal mechanism is largely unknown. Understanding how neuropeptides (small molecules used for communication between brain cells) change the way the brain interprets food odors is an important step in disentangling the complex relationship between smell, hunger, and behavior in the human brain.

PI_NAMEs: ASAHINA, KENTA  (contact)

PROGRAM_OFFICER_NAME: SULLIVAN, SUSAN L

PROJECT_TERMS: Address;Afferent Neurons;Aggressive behavior;Animal Feed;Animals;Anxiety;Area;Behavior;Behavioral;Behavioral Paradigm;behavioral response;Biological;Brain;brain cell;Cells;Central Nervous System;Chemicals;Cognitive;Communication;Complex;Cues;deprivation;Detection;Drosophila genus;Drosophila melanogaster;Esthesia;Event;Exhibits;Experimental Genetics;experimental study;fly;Food;Funding;Genes;Genetic;Goals;Homologous Gene;Hormones;Human;Hunger;Individual;Knowledge;male;Mediating;Midgut;model organism;Modeling;Molecular;Motivation;National Institute on Deafness and Other Communication Disorders;Nervous System;neural;Neurohormones;Neuromedin U;Neuromodulator;Neurons;Neuropeptides;neuroregulation;novel;Nutrient;Nutritional;Odors;Olfactory Pathways;olfactory sensory neurons;olfactory threshold;Pathway interactions;Perception;Pheromone;Physiological;Physiological Processes;Physiology;Play;Population;Process;programs;Proteins;receptor;Receptor Gene;reproductive;Research;Resources;response;Role;Sensory;sensory input;sensory stimulus;sensory system;Shapes;Signal Transduction;small molecule;Smell Perception;Social Behavior;Social Interaction;Source;Specific qualifier value;Stimulus;Strategic Planning;Taste Perception;Testing;transmission process;Volatilization;Yeasts

PROJECT_TITLE: Peptidergic neuromodulation of microcircuits that control chemosensation-induced behaviors

STUDY_SECTION: NIC

STUDY_SECTION_NAME: Neuroscience of Interoception and Chemosensation Study Section[NIC]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Aggregation of the RNA binding protein TDP-43 has been reported in almost every age-dependent neurodegenerative disease, including frontal temporal dementia (FTD), ALS, Alzheimer's disease (AD), and in ~100% of a recently recognized AD-like dementia in the oldest of the elderly. We now seek to identify how acetylation of TDP-43, a modification that inhibits its RNA binding and drives its separation into liquid-like droplets and subsequent aggregation. We will also develop a potential therapeutic approach for TDP-43 proteinopathies by identification and use of synthetically evolved single chain antibodies to aggregated TDP-43 to catalyze its proteasome-mediated degradation.

PI_NAMEs: CLEVELAND, DON W (contact)

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Acetylation;Acetyltransferase;age related decline;age related neurodegeneration;aged;Aging;ALS patients;Alzheimer's Disease;Alzheimer's disease patient;Amyotrophic Lateral Sclerosis;Antibodies;ATP phosphohydrolase;Automobile Driving;Autopsy;Binding;Biological;Biology;Brain;Cell model;Central Nervous System;Complex;Cytoplasm;Deacetylase;Deacetylation;Dementia;Disease;efficacy evaluation;Elderly;Engineering;Enzymes;EP300 gene;Excision;Exhibits;Frontotemporal Dementia;Genes;Heat-Shock Proteins 70;Hippocampus;Histone Deacetylase;Human;human induced pluripotent stem cells;induced pluripotent stem cell;Induced pluripotent stem cell derived neurons;inhibitor;insight;limbic-predominant age-related TDP-43 encephalopathy;Link;Liquid substance;Mediating;Methods;Modification;Molecular Chaperones;Motor Neurons;mouse model;multicatalytic endopeptidase complex;mutant;Mutation;Names;nanobodies;neuron loss;Neurons;neurotoxicity;Nuclear;Outcome;Pathologic;Pathology;Patients;Periodicity;Phase;Phase Transition;Phosphorylation;prevent;Property;protein TDP-43;Regulation;Reporting;RNA Binding;RNA Processing;RNA Splicing;RNA-Binding Proteins;Rodent Model;Role;Spinal Cord;Stress;stress granule;Syndrome;TDP-43 aggregation;Therapeutic;Transcription Initiation;transcriptome;ubiquitin-protein ligase

PROJECT_TITLE: TDP-43 acetylation, phase separation, aggregation, and clearance by antibody-mediated degradation

STUDY_SECTION: CMND

STUDY_SECTION_NAME: Cellular and Molecular Biology of Neurodegeneration Study Section[CMND]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE Functional and cognitive recovery after traumatic brain injury (TBI) is highly variable and poorly understood. Better TBI prognostic models are urgently needed for individual patient care and prognostic stratification for TBI clinical trials. This career development award led by Amelia W. Maiga, MD, MPH will (1) create a better prognostic model with time-varying clinical data, image-based biomarkers, and TBI-specific biomarkers, and (2) describe distinct trajectories of functional and cognitive recovery after hospitalized TBI.

PI_NAMEs: MAIGA, AMELIA  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA ALISE

PROJECT_TERMS: Accounting;Address;Admission activity;Area;Award;Biological Markers;brain dysfunction;Calibration;career development;Caring;Clinical;clinical care;Clinical Data;clinical decision-making;clinical imaging;Clinical stratification;clinical translation;Clinical Trials;cognitive recovery;cohort;Communication;Critical Illness;Data;Decision Making;Delirium;Development;Development Plans;Discrimination;Elements;Engineering;Enrollment;Environment;expectation;experience;Family;follow-up;Functional disorder;functional outcomes;Funding;Glasgow Outcome Scale;Glial Fibrillary Acidic Protein;Goals;Grant;Hospitalization;Hospitals;Hour;Image;imaging biomarker;Impaired cognition;Impairment;improved;individual patient;Injury;Inpatients;Institute of Medicine (U.S.);K-Series Research Career Programs;Knowledge;Laboratories;Leadership;Logistic Regressions;Long-Term Effects;Longterm Follow-up;Medicine;Mentors;Mentorship;model development;Modeling;MRI Scans;multidisciplinary;Multiple Trauma;Nervous System Physiology;Neurocognitive;neuroimaging;Neurologic;Neuronal Plasticity;novel;Organ;Outcome;Patient Care;patient oriented;patient responsibilities;Patient Selection;Patients;Pattern;Persons;Positioning Attribute;Predictive Factor;predictive modeling;Principal Investigator;prognostic;prognostic model;prognostication;Provider;Public Health;radiomics;Recovery;Recovery of Function;Reporting;Research;Research Priority;resilience;risk prediction;Scientist;severe injury;Signal Transduction;skills;specific biomarkers;Statistical Models;Stratification;Subgroup;Surgeon;Survivors;survivorship;symposium;TBI Patients;TBI treatment;Testing;Time;Training;Translating;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;UCHL1 gene;United States National Academy of Sciences;United States National Institutes of Health;Update;Work;X-Ray Computed Tomography

PROJECT_TITLE: Improving Prognostication for Traumatic Brain Injury

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ISB-D(02)M]


NIH_SPENDING_CATS: Biotechnology;Drug Abuse (NIDA only);Genetics;HIV/AIDS;Infectious Diseases;Substance Misuse

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE  The single most significant obstacle to total HIV clearance and therefore, a “cure” for HIV in humans is presence of a reservoir of silent HIV genomes that are not targeted by the immune system or by any available antiviral drug. We propose a strategy for the comprehensive cataloging of genes involved in HIV latency maintenance based on a novel technology for high throughput and versatile screening of 10s of thousands of genes in combination with other drugs. The goal is to find targets that more broadly activate HIV from latency while at the same time providing a greater degree of specificity for the virus in order to guide HIV elimination efforts.

PI_NAMEs: EMERMAN, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: Adopted;Anti-viral Agents;Anti-viral Therapy;antiretroviral therapy;Basic Science;burden of illness;Cataloging;cell killing;Cell model;cell type;Cells;Chemicals;Clustered Regularly Interspaced Short Palindromic Repeats;Combination Drug Therapy;Communities;Dose;drug of abuse;Genes;Genetic;Genetic Screening;Genetic screening method;Goals;high throughput technology;HIV;HIV Budding;HIV Genome;HIV Infections;HIV/AIDS;Human;Immune system;Immunologics;in vivo;Individual;innovation;Intervention;Maintenance;Methods;Modeling;new technology;novel;novel strategies;Pathway interactions;Pharmaceutical Preparations;Pharmacotherapy;Proviruses;Research;screening;Specificity;synergism;Techniques;Technology;Time;transmission process;Virus;Virus Latency

PROJECT_TITLE: HIV-CRISPR:  A novel approach to the comprehensive discovery of HIV latency factors


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Biotechnology;Clinical Research;Genetics;Rheumatoid Arthritis

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative The majority of rheumatoid arthritis and juvenile idiopathic arthritis patients experience episodic arthritis flares, causing them to require life-long medications to control their disease. We have identified tissue resident memory T cells (TRM) that remain in the joint during remission and act as key mediators of arthritis flares. Understanding how TRM form in the joint will help us design new therapies that can prevent arthritis flares.

PI_NAMEs: CHANG, MARGARET  (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: 3-Dimensional;Adoptive Transfer;Advisory Committees;Affect;Antibodies;Antigens;Area;Arthralgia;Arthritis;arthritis therapy;arthropathies;Attenuated;Autoimmune Diseases;Bioinformatics;Biology;Boston;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Lineage;Cells;Cellular biology;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Childhood;Chronic;chronic autoimmune disease;Chronic Childhood Arthritis;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;confocal imaging;Coupled;CRISPR/Cas technology;Data;design;Development;Disease;Disease remission;disorder control;Doctor of Medicine;Doctor of Philosophy;Effector Cell;Endothelial Cells;Environment;Event;Exhibits;experience;Fatty Acids;Fibroblasts;Flare;Foundations;Functional disorder;Funding;Future;Gene Expression;Gene Expression Profiling;Gene Targeting;Genes;Genetic Transcription;Goals;Head;Homing;Hospitals;Human;human disease;human model;Immune;immune activation;Immunology;Individual;Inflammation;Inflammatory;Inflammatory Arthritis;insight;Institution;Interruption;joint inflammation;Joints;Knowledge;Laboratories;Learning;Ligands;lymph nodes;Maintenance;Mediating;Mediator;medical schools;Membrane Proteins;Memory;Mentors;Mentorship;Methods;migration;Modeling;mouse model;mRNA Expression;Mus;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;new therapeutic target;novel strategies;novel therapeutics;Organoids;Pathway interactions;Patients;Pattern;Pediatric Hospitals;Periodicals;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;Physicians;Population;prevent;Process;protein expression;receptor;recruit;Recurrence;Recurrent disease;Research Personnel;residence;Resistance;Resources;Rheumatoid Arthritis;rheumatologist;Role;RUNX3 gene;Scientist;Series;Signal Transduction;single cell analysis;single cell sequencing;single-cell RNA sequencing;Site;skills;Sterility;Stromal Cells;Surface;Synovial Membrane;System;T memory cell;T-Cell Activation;T-Cell Development;T-Cell Receptor;T-Lymphocyte;Testing;TGFBR2 gene;Therapeutic;therapeutic target;three-dimensional modeling;Time;Tissue Differentiation;Tissue Model;tissue resident memory T cell;Tissue-Specific Gene Expression;Tissues;Training;transcriptomics;Translational Research;uptake;Woman;Work

PROJECT_TITLE: Development of resident memory T cells in the synovium


ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: NARRATIVE Genome instability is a common feature of multiple human diseases. This project focuses on the signaling mechanisms of Polo-like kinase 1 at chromosome centromeres that are required to maintain stability. By understanding chromatin-based signals, it will be possible to develop a basic mechanistic understanding of disease.

PI_NAMEs: WEAVER, BETH A (contact)

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Affect;arm;Binding;Biochemical;Biological Assay;Biological Process;Bloom Syndrome;Case Study;Cells;Centromere;centromere protein C;chemical genetics;Chemicals;Chromatin;Chromosome Arm;Chromosome Segregation;Chromosomes;Complex;Disease;Dislocations;DNA-Directed RNA Polymerase;Environment;Enzymes;Event;experimental study;Genetic Transcription;genome integrity;Genome Stability;Genomic Instability;Goals;helicase;Human;human disease;innovation;insight;Kinetochores;Learning;Location;Mammalian Cell;Maps;Mediating;Microscopic;Microtubules;Mitosis;Mitotic;Mitotic spindle;Phenotype;Phosphorylation;Phosphorylation Site;PLK1 gene;Production;Proteins;recruit;Regulation;RNA;Role;Signal Transduction;Structure;System;Techniques;Testing;Transcript;Transcriptional Regulation;ultra high resolution;Work

PROJECT_TITLE: Mechanisms of Plk1 at the mitotic centromere

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Clinical Research;Diabetes;Kidney Disease;Precision Medicine

ORG_NAME: UNIVERSITY OF WASHINGTON

PHR: PROJECT NARRATIVE Diabetic kidney disease (DKD) is highly prevalent and is associated with substantial morbidity and mortality. This project will define patterns of autophagy in human DKD, identify associations of autophagy with histopathology and kidney function, and validate blood and urine biomarker signatures reflecting kidney autophagy. Overall, this work will yield novel insights into the role of autophagy in human DKD and facilitate future investigation of kidney autophagy, paving the way for mechanism-focused diagnostic, prognostic, and therapeutic strategies.

PI_NAMEs: LIMONTE, CHRISTINE  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Adult;Advanced Glycosylation End Products;Affect;Agonist;Albumins;Albuminuria;Autophagocytosis;Autophagosome;Bioinformatics;biomarker signature;Blood;career;career development;Cathepsins;cell injury;Chronic Kidney Failure;Clinical;Clinical Trials;cohort;Cohort Studies;Cytoplasm;Data;design;detection of nutrient;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Diagnosis;Diagnostic;disease model;disorder subtype;Electron Microscopy;End stage renal failure;Enrollment;Enzymes;Epidemiology;Epithelial Cells;Excretory function;experience;Experimental Diabetes Mellitus;Experimental Models;Fellowship;Fibrosis;Foundations;Future;Gene Expression;Genes;Glomerular Filtration Rate;GLP-I receptor;Glucose;Goals;Heterogeneity;Histopathology;Homeostasis;Human;Hyperglycemia;hypertensive;Hypoxia;Immunohistochemistry;improved;individual patient;Inflammation;inhibitor;Injury;Injury to Kidney;insight;Investigation;Kidney;kidney biopsy;Knowledge;Laboratories;LCN2 gene;light microscopy;Longitudinal cohort;Lysosomes;Maintenance;Measures;Mediating;Mentors;Methodology;Modeling;Molecular;molecular phenotype;Morbidity - disease rate;mortality;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel therapeutic intervention;novel therapeutics;Organelles;Outcome;Oxidative Stress;Participant;Pathogenesis;Pathway interactions;Pattern;personalized diagnostics;personalized therapeutic;Persons;Physicians;Pima Indian;Plasma;Play;precision medicine;Prediction of Response to Therapy;Predisposition;Process;Prognosis;prognostic;Proteins;Proteomics;Renal function;Research;research and development;Research Project Grants;response;Role;Scientist;severe injury;Severities;single-cell RNA sequencing;Sodium;Subgroup;symporter;Testing;Therapeutic;Tissues;Training;Tubular formation;Universities;Urine;Washington;Work

PROJECT_TITLE: Autophagy in Diabetic Kidney Disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Cardiovascular;Clinical Research;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Peripheral artery disease, atherosclerotic occlusive disease of the lower extremities, occurs in nearly a quarter of a billion people, disproportionately affects women and individuals with diabetes, and commonly leads to amputations. Current therapies are inadequate. This application is relevant to public health because it has the potential to discover new approaches to decrease the burden of peripheral artery disease in the United States.

PI_NAMEs: SEMENKOVICH, CLAY F. (contact)

PROGRAM_OFFICER_NAME: CATANIA, SELEN MURATOGLU

PROJECT_TERMS: Address;Adherens Junction;Affect;Aging;aging population;Amputation;Animals;Arteries;Atherosclerosis;Awareness;Biological Markers;Biology;Blood Vessels;Cardiovascular system;Caring;Cerebrovascular Disorders;Cessation of life;Chronic;Clinical;comparison control;Coronary heart disease;Defect;Diabetes Mellitus;Disease;Disproportionately impacts women;Endothelium;Engineering;enzyme activity;Enzymes;Epidemic;Event;fatty acid metabolism;Fatty Acids;Female;Fibronectins;Fright;Functional disorder;Genetic;genetic approach;Health Care Costs;Hindlimb;Human;human female;human male;human tissue;Hypertension;Impairment;Individual;insight;Ischemia;Knowledge;Lipoproteins;Lower Extremity;male;Membrane;men;Metabolic syndrome;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Myocardial Infarction;Myocardial Ischemia;neglect;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Palmitates;palmitoylation;Patients;Peripheral;Peripheral arterial disease;Persons;pharmacologic;Physiologic pulse;Physiological;Population;Post-Translational Protein Processing;Prevalence;Proteins;Proteomics;Public Health;Recovery;Risk;Risk Factors;sex;sex as a biological variable;Stroke;Testing;Therapeutic;Tissues;trafficking;Translating;United States;Vascular Diseases;Vascular remodeling;Woman;Women's prevalence;Work

PROJECT_TITLE: Lipidation and Vascular Disease

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_DEPT: BIOLOGY

PHR: PROJECT NARRATIVE Francois Jacob, the pioneering molecular geneticist, said that "The dream of every cell is to become two cells". This dream is challenging to achieve. For example, in humans the 6.2 billion DNA letters that encode the information for building and maintaining our bodies are organized into 46 chromosomes that must be copied and then precisely distributed to produce two identical daughter cells. Errors in the distribution of chromosomes cause birth defects and contribute to the ability of cancers to develop and evade treatment. The goals of this project are to address how cells achieve the Jacobian dream, preserving the integrity of their genomes through the process of division.

PI_NAMEs: DESAI, ARSHAD  (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Acceleration;Address;Adult;Anaphase;Astronomy;aurora kinase A;Back;Binding;Binding Sites;Caenorhabditis elegans;Cell Cycle Progression;Cell division;Cell Physiology;Cell Separation;Cells;checkpoint inhibition;Chromatin;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;Congresses;Coupled;Data;daughter cell;depolymerization;Development;DNA;Dreams;Dynein ATPase;Embryo;Embryonic Development;Ensure;Equilibrium;Event;Excision;Genetic Complementation Test;Genetic Transcription;Genome;Genomic Instability;Genomics;Goals;Growth;Heart;Homeostasis;Human;Human body;in vivo;Individual;Infertility;Investments;Kinetochores;Letters;Link;loss of function;Malignant Neoplasms;Mechanics;Metaphase Plate;Microtubule Polymerization;Microtubules;Mitosis;Mitotic;Mitotic Chromosome;Modeling;Molecular;Motor;Mutate;MXD1 gene;novel therapeutics;Oocytes;Organelles;Organism;Phase;Phosphotransferases;PLK1 gene;polymerization;Polymers;preservation;prevent;Process;Proteins;recruit;Role;scaffold;segregation;Set protein;Signal Transduction;Specific qualifier value;Therapeutic;Therapeutic Intervention;Time;Tissues;Translations;Work

PROJECT_TITLE: Kinetochore Specification and Function


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;HIV/AIDS;Human Fetal Tissue;Infectious Diseases

ORG_CITY: GAINESVILLE

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Narrative  The goal of this project is to evaluate repurposing the FDA-approved drug spironolactone (SP) currently used to treat a range of conditions, e.g., heart failure and hypertension, for inhibition of HIV. We have shown in cultured cells that SP blocks HIV gene expression and propose to evaluate this potential in the humanized mouse model of HIV infection, either alone, or in combination with another HIV gene expression inhibitor, dCA. We expect to gain valuable insight into the benefits of adding HIV transcriptional inhibitors to current antiretroviral therapy.

PI_NAMEs: GARCIA-MARTINEZ, J. VICTOR ;VALENTE, SUSANA T (contact)

PROGRAM_OFFICER_NAME: LACOURCIERE, GERARD

PROJECT_TERMS: Acceleration;age acceleration;Aldosterone Antagonists;antagonist;antiretroviral therapy;Attention;Biological Assay;BLT mice;Bone Marrow;Cancer Patient;CD4 Positive T Lymphocytes;Cell Line;Cells;Chronic;Clinic;Clinical;Clinical Research;Clinical Trials;comorbidity;cortistatin;cost;Cultured Cells;Defect;detection limit;Disease Progression;Disease remission;disease transmission;DNA Integration;Dose;Drug resistance;Epigenetic Process;epigenetic silencing;ERCC3 gene;Evolution;experience;FDA approved;Future;Gene Expression;Genes;genetic inhibitor;Genetic Transcription;Goals;Heart failure;HIV;HIV anti-retroviral;HIV Infections;HIV tat Protein;HIV-1;humanized mouse;Hypertension;immune activation;improved;improved outcome;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammation;inhibitor;insight;Integration Host Factors;interest;Interruption;knock-down;large scale production;Length;Liver;memory CD4 T lymphocyte;Mineralocorticoid Receptor;Modeling;Monitor;mouse model;new therapeutic target;novel;Outcome;Pathway interactions;Persons;Pharmaceutical Preparations;Positioning Attribute;promoter;Provirus Integration;Proviruses;reactivation from latency;Residual state;Resistance;Rest;small hairpin RNA;Spironolactone;targeted agent;Testing;Thymus Gland;Time;Tissues;transcription factor;transcription factor TFIIH;Transcription Initiation Site;transcriptome sequencing;transcriptomics;Viral;Viral Proteins;viral rebound;Viral reservoir;viral resistance;viral RNA;Viremia;Virus

PROJECT_TITLE: Exploration of novel block-and-lock agents alone and in combination for HIV remission in humanized mice


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Closing critical gaps in the understanding of AD etiopathogenesis by clarifying the neurobiological basis of heterogeneity in AD clinical presentation may result in novel biomarkers and targets for the prevention and treatment of this devastating disease. This renewal K24 research and training program will expand the capacity of a productive investigator to train advanced trainees in POR in age-related neuropathology. Furthermore, it will help me to make meaningful progress towards her long-term goal of conquering neurodegenerative diseases by carefully mapping disease-associated lesions in well-characterized human postmortem tissue and correlate these findings with clinical, epidemiological and molecular features

PI_NAMEs: GRINBERG, LEA TENENHOLZ (contact)

PROGRAM_OFFICER_NAME: MARTIN, DAMALI

PROJECT_TERMS: Age;age related;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease therapy;Amnestic Disorder;Amyloid beta-Protein;Area;association cortex;asymptomatic Alzheimer's disease;Atrophic;Automobile Driving;Autopsy;behavioral variant frontotemporal dementia;Biological;Brain;Brain region;brain tissue;California;career;Cells;cerebral atrophy;Cessation of life;Clinical;clinical heterogeneity;Clinical Research;Cognitive;Cohort Studies;Collaborations;Collection;comorbidity;corticobasal syndrome;Data;Data Analyses;Dedications;Dementia;differential expression;Disease;effective therapy;Epidemiology;experience;extracellular;Faculty;Functional disorder;Funding;Genetic;Goals;Grant;hands on research;Heterogeneity;Hippocampal Formation;Human;human RNA sequencing;Immunofluorescence Immunologic;Impaired cognition;In Situ Hybridization;Individual;Infrastructure;innovation;interdisciplinary approach;International;Interruption;Intrinsic factor;Lesion;Libraries;Longitudinal cohort study;Machine Learning;Manuscripts;Maps;Medical Students;Memory;Mentors;Metabolic;Methods;Mid-Career Clinical Scientist Award (K24);mid-career faculty;Molecular;multidisciplinary;neocortical;Neuroanatomy;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neurologist;neuron loss;neuronal patterning;Neurons;neuropathology;neurotoxicity;novel;novel marker;Pathologic;Pathology;Pathway interactions;patient oriented;Pattern;Persons;Phenotype;Populations at Risk;Preparation;prevent;Prevention;Primary Progressive Aphasia;Productivity;programs;Protocols documentation;recruit;regional difference;Regional Disease;Research;Research Personnel;research study;residence;Role;San Francisco;single nucleus RNA-sequencing;Symptoms;Syndrome;tau aggregation;tau Proteins;Testing;Time;Tissue Sample;Tissues;Training;Training Programs;Transcript;United States National Institutes of Health;Universities;University resources;Variant;Work;Writing

PROJECT_TITLE: Neuropathological changes underlying clinical heterogeneity in Alzheimer disease

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical and Translational Research of Aging Study Section[NIA -T]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE DNA damage by endogenous and environmental agents to nuclear and mitochondrial DNA has been identified as a causative factor in cancer, neurodegeneration and inflammation. In this project, we will determine how mitochondria deal with DNA damage, provide new insights into the relationship between mitochondrial DNA and energy metabolism and elucidate differences in how cancer and non-malignant cells respond to mitochondrial dysfunction. The results of these studies will advance our understanding of the causes of mitochondrial dysfunction and guide the development of novel therapeutic strategies for human diseases associated with mitochondrial dysfunction.

PI_NAMEs: TOMKINSON, ALAN E (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Adenine;Aging;base;Base Excision Repairs;Binding;cancer cell;Carrier Proteins;CASP1 gene;Cell Death;cell growth regulation;Cell Survival;Cells;Cellular Stress;Complex;Cytoplasm;Cytosine;Data;design;Development;DNA;DNA Damage;DNA glycosylase;DNA lesion;DNA Ligases;DNA metabolism;DNA Repair Enzymes;DNA Repair Inhibition;Electron Transport;Energy Metabolism;environmental agent;Excision;Exposure to;free radical oxygen;Functional disorder;Generations;Genes;Genetic Transcription;Genome;Genome Stability;Guanine;Health;Human;human disease;Hydrogen Peroxide;improved;Inflammasome;Inflammation;Inflammatory;inhibitor;Innate Immune Response;insight;interest;Lesion;Ligase;Link;macromolecule;Maintenance;Malignant Neoplasms;Mediating;Metabolic Diseases;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Mitochondrial Electron Transport Complex I;mitochondrial genome;Mitochondrial Proteins;Mutation;NADH dehydrogenase (ubiquinone);Nerve Degeneration;Neurodegenerative Disorders;Non-Malignant;novel;novel therapeutic intervention;Nuclear;Nucleic Acids;OGG1 gene;Organelles;oxidative damage;oxidative DNA damage;Oxidative Phosphorylation;Oxidative Stress;Pathologic;Pathway interactions;Play;Poly(ADP-ribose) Polymerase Inhibitor;Predisposition;prevent;Process;Production;Protein Biosynthesis;Proteins;RARRES3 gene;Reactive Oxygen Species;Reagent;refractory cancer;Regulation;repaired;Role;Site;Stimulator of Interferon Genes;Superoxides;Testing;Therapeutic;therapeutic target;therapy resistant;tool;Work;XRCC1 gene

PROJECT_TITLE: Roles of Lig3 and XRCC1 Genes in Genome Stability

STUDY_SECTION: CE

STUDY_SECTION_NAME: Cancer Etiology Study Section[CE]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Antibiotic resistance especially in the ESKAPE pathogens represents a significant public health crisis. Elucidation of the role of extracellular heme metabolism and its integration into the virulence networks of P. aeruginosa will aid in identifying novel therapeutic strategies at the interface of iron homeostasis and virulence.

PI_NAMEs: OGLESBY, AMANDA GAIL;WILKS, ANGELA  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accounting;Aerobic;Affect;Anti-Bacterial Agents;Antibiotic Resistance;antimicrobial;antimicrobial resistant pathogen;antitermination;Bacterial Infections;Binding;Binding Proteins;Biochemical;biochemical tools;Biological Process;biophysical techniques;biophysical tools;Biophysics;Cells;Cessation of life;chronic infection;Citric Acid Cycle;constitutive expression;Cytoplasm;Data;DNA;DNA biosynthesis;Drug resistance;EMSA;enteric pathogen;ESKAPE pathogens;Event;extracellular;Fluorescence Anisotropy;Future;Gene Expression;Genes;Genetic;genetic regulatory protein;Genetic study;Genetic Transcription;Goals;Heme;heme-binding protein;Homeostasis;Homologous Gene;human pathogen;in vivo;Infection;innovation;Iron;Klebsiella pneumoniae;Laboratories;Life;Link;Membrane;Metabolism;Methods;Microbial Biofilms;microbial homeostasis;Micronutrients;microorganism;Molecular;mRNA Transcript Degradation;Mutation;Mycoses;new therapeutic target;novel therapeutic intervention;Oxidation-Reduction;Oxidative Stress;Oxygenases;pathogen;pathogenic bacteria;pathogenic microbe;Peptide Hydrolases;Post-Transcriptional Regulation;posttranscriptional;promoter;Property;Proteins;Proteomics;Pseudomonas aeruginosa;Public Health;receptor;Regulation;Regulon;Reporting;Respiration;rho;RNA;RNA Binding;RNA chemical synthesis;Role;Shigella dysenteriae;Siderophores;Signal Transduction;Site-Directed Mutagenesis;System;Testing;Time;Toxin;trait;transcription regulatory network;Transcriptional Regulation;Up-Regulation;uptake;Uropathogenic E. coli;Variant;Virulence;Virulence Factors

PROJECT_TITLE: Integration of heme acquisition and signaling in Gram-negative pathogens

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-B(02)M]


ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative One of the most intriguing questions in science is how developmental pattern formation is executed so robustly despite unavoidable cell-to-cell variability in gene expression. We will investigate the mechanisms buffering this variability during vertebral segmentation. We will also elucidate how the transcriptome-level reorganization (expression levels and variability of thousands of genes) is controlled by cell signaling gradients. These information will be significant for understanding and potentially preventing vertebral malformations.

PI_NAMEs: OZBUDAK, ERTUGRUL M (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Anterior;Biochemical Reaction;Body Size;Buffers;Cell Count;cell growth;Cell Size;Cells;Characteristics;Chemicals;Complex;Congenital Abnormality;Development;Developmental Process;dosage;Embryo;Exhibits;Family;Feedback;Gene Expression;gene regulatory network;Genes;Genetic;Goals;Kinetics;Ligands;malformation;Mathematics;Mesoderm;Noise;notch protein;Pattern Formation;Periodicity;Phase;Phenotype;Population;prevent;programs;Reproducibility;Science;Segmentation Clock Pathway;Signal Transduction;Somites;somitogenesis;spine bone structure;Statistical Models;Stochastic Processes;System;Tail;Time;transcriptome;Tretinoin

PROJECT_TITLE: Regulatory Mechanisms Governing Precision in Vertebral Segmentation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: ATLANTA

ORG_DEPT: PATHOLOGY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: NARRATIVE One of the most pressing needs to combat the HIV pandemic is a vaccine that can elicit antibodies that can neutralize the virus. The genetics of antibodies is remarkably complex, and understanding how they develop during vaccine responses in humans has only been possible in recent years. The goal of this grant proposal is to conduct genomic sequencing of the antibody region in rhesus monkeys that are used in HIV vaccine studies, and build a database to provide this data to the scientific community.

PI_NAMEs: BOSINGER, STEVEN EDWARD (contact);WATSON, COREY TAYLOR

PROGRAM_OFFICER_NAME: PALIN, AMY COLLEEN

PROJECT_TERMS: 2019-nCoV;Acquired Immunodeficiency Syndrome;Address;AIDS Vaccines;Alleles;Antibodies;Antigens;Applications Grants;Autologous;Benchmarking;Bioinformatics;Breeding;Catalogs;cohort;combat;Communities;Complex;Data;Data Set;Databases;Development;Enrollment;Epitopes;Evolution;Foundations;Gene Targeting;Genetic;genetic information;Genome;genome resource;Genomics;Genotype;Germ Lines;Germ-Line Mutation;Goals;Haplotypes;HIV;HIV vaccine;Human;Immunization;Immunoglobulin Genes;Immunoglobulins;Impairment;Individual;Knowledge;Longitudinal Studies;Macaca mulatta;Methodology;Modeling;Monkeys;Mutation;neutralizing antibody;novel;novel strategies;Outcome;pandemic disease;pathogen;Population;Population Heterogeneity;Positioning Attribute;preclinical study;Primates;Protocols documentation;R24;reference genome;Reporting;Research;Resolution;Resources;response;T-Lymphocyte;Testing;tool;Vaccinated;vaccine efficacy;Vaccine Research;vaccine response;vaccine strategy;vaccine trial;Vaccines;Variant;Virus;web-accessible;Work

PROJECT_TITLE: Population genotyping of the germline immunoglobulin repertoire in AIDS-designated rhesus macaque breeding colonies


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric;Pediatric Cancer;Prevention;Rare Diseases;Sleep Research;Telehealth

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

PHR: Relevance Statement This study will evaluate the impact of internet-based cognitive behavioral therapy on symptoms of insomnia in adult survivors of childhood cancer. We will also examine the impact of improved sleep on neurocognitive impairment, emotional distress, cardiovascular risk, and quality of life in a large sample of adult survivors of childhood cancer. Results will inform current standard-of-care as few efficacious interventions are available for the remediation of these relatively common and highly comorbid late effects in long-term survivors.

PI_NAMEs: BRINKMAN, TARA M (contact);KRULL, KEVIN R

PROGRAM_OFFICER_NAME: DEAN, DAVID WORTH

PROJECT_TERMS: Address;Adolescent;Adult;Anxiety;Behavior;Biological Markers;cancer therapy;Cardiac health;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Child;childhood cancer survivor;Childhood Cancer Survivor Study;Childhood Cancer Treatment;Chronic;Clinical;cognitive performance;Cognitive Therapy;Cohort Studies;Comorbid Insomnia;comorbidity;comparison intervention;curative treatments;Development;Diagnosis;efficacious intervention;efficacy evaluation;eHealth;emotional distress;emotional symptom;Fatigue;Female;future implementation;General Population;Geography;Health;health care availability;Health Professional;health related quality of life;improved;improvement on sleep;Inflammation;Internet;Intervention;intervention effect;Late Effects;Long-Term Survivors;male;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediating;Mental Depression;Mental Health;Morbidity - disease rate;Neurocognitive;Neurocognitive Deficit;neurotoxic;Nonpharmacologic Therapy;Online Systems;Outcome;Patient Education;physical conditioning;Population;Population Heterogeneity;post intervention;programs;psychologic;Quality of life;Randomized;randomized, clinical trials;recruit;reduce symptoms;remediation;Reporting;Risk;Sampling;Sleep disturbances;Sleeplessness;standard of care;Survivors;survivorship;symptomatic improvement;Symptoms;Thinking;Toxic effect;Training;United States;web-based intervention

PROJECT_TITLE: eHealth Intervention for Late Effects of Childhood Cancer

STUDY_SECTION: PRDP

STUDY_SECTION_NAME: Psychosocial Risk and Disease Prevention Study Section[PRDP]


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Genetics;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARATIVE Ewing Sarcoma Family of Tumors (ESFT) are bone and soft tissue cancers that affect children and young adults. Despite aggressive treatments with surgery, radiation and multi-agent chemotherapy, patients with advanced disease have a 5-year survival rate of less than 30%, and thus, there is a need for new ESFT therapy. This study will investigate our discovery that ESFT cells are dependent on the FEN1-nuclease for viability to provide a comprehensive pre-clinical evaluation of FEN1-inhibitors as novel and rational therapeutics for treating ESFT.

PI_NAMEs: CHOO, SUN HA;KOLODNER, RICHARD D (contact);WANG, JEAN Y.J.

PROGRAM_OFFICER_NAME: GREENBERG, WILLIAM A

PROJECT_TERMS: Ablation;Address;Adolescent;advanced disease;Affect;aggressive therapy;Animals;Bar Codes;Biological Assay;Biological Availability;Biopsy;Bone neoplasms;Bone Tissue;brca gene;BRCA1 gene;cancer cell;Cell Death;Cell Line;cell transformation;Cells;Cessation of life;chemotherapy;Child;Chromosome Breakage;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;Collection;Coupled;CRISPR library;CRISPR/Cas technology;cytotoxic;data mining;Dependence;DNA;DNA Binding Domain;DNA biosynthesis;DNA Damage;DNA Repair;Drug Kinetics;Drug resistance;endonuclease;Enzymes;Ewings sarcoma;EWS-FLI1 fusion protein;EWSR1 gene;Family;FLI1 gene;Future;Genes;Genetic;Genetic Transcription;genome-wide;Goals;Growth;Guide RNA;Human;improved;In Vitro;in vivo;in vivo evaluation;inhibitor;Institutional Review Boards;Knock-out;Legal patent;Letters;Libraries;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;Mitotic;Molecular;Molecular Medicine;mouse model;Mus;neoplastic cell;novel;novel therapeutics;nuclease;Nude Mice;Okazaki fragments;Oncoproteins;Operative Surgical Procedures;patient derived xenograft model;patient prognosis;Patients;Pediatric Oncologist;Pediatrics;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;preclinical evaluation;preclinical study;Primitive Neuroectodermal Tumor;Principal Investigator;Process;Protocols documentation;Radiation;Reporting;Research;Research Project Grants;Resected;Resistance;response;Sampling;Signal Transduction;Small Interfering RNA;small molecule;soft tissue;Specificity;Statistical Methods;Survival Rate;synergism;targeted nucleases;targeted treatment;Testing;Therapeutic;three dimensional cell culture;Transactivation;Transplantation;tumor;Tumor Cell Line;tumor growth;Tumor Volume;tumorigenesis;Xenograft Model;Xenograft procedure;young adult

PROJECT_TITLE: FEN1-Nuclease-Targeted Therapy for Ewing Sarcoma


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLIFTON PARK

ORG_NAME: KITWARE, INC.

PHR: PROJECT NARRATIVE Slicer Shape AnaLysis Toolbox (SALT) was developed as an open-source, free comprehensive software that allows biomedical scientists to precisely locate shape changes in their imaging studies. This proposal is designed to increase the continued success of SALT by recognizing that shape models and dynamic anatomical changes are challenging to interpret despite quantification of the geometry of physical objects. We will address this need by incorporating state-of-the-art and interpretable shape statistics methodology into SALT and new driving biological problems to illustrate their utility while continuing to provide effective user support.

PI_NAMEs: PANIAGUA, BEATRIZ  (contact)

PROGRAM_OFFICER_NAME: DUAN, QI

PROJECT_TERMS: 3-Dimensional;Accounting;Algorithms;Anatomy;Architecture;Automobile Driving;base;Biological;Biological Markers;biomedical imaging;Biomedical Research;biomedical scientist;Brain;Classification;clinical application;Clinical Research;Communities;Complex;complex data;computer science;Computer software;Consultations;Data;deep learning;design;Development;digital;Disease;Documentation;Educational workshop;Effectiveness;efficacy evaluation;Ensure;Event;fetal;Fostering;Funding;geometric structure;Geometry;Goals;Image;Image Analysis;imaging study;improved;Infrastructure;innovation;insight;large scale data;longitudinal analysis;Longitudinal Studies;Measures;Medical;Medical Imaging;Methodology;Methods;Modeling;Modernization;Nature;new technology;novel;Online Systems;open source;outreach;Pediatric cardiology;Phase;Population;Process;Publications;Research;Research Design;Research Personnel;shape analysis;Shapes;Software Tools;Statistical Methods;statistics;Structure;success;Surveys;Techniques;Testing;Time;tool;Training;Ultrasonography;usability;Variant;Visualization;web site

PROJECT_TITLE: Shape Analysis Toolbox: From medical images to quantitative insights of anatomy

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences;Rare Diseases

ORG_CITY: MORGANTOWN

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE The focus of the proposed study is to decipher the mechanism behind the synthesis and maturation of phosphodiesterase (PDE6), an enzyme essential for our vision. We hope to use the knowledge gained from this study to design novel therapies for PDE6 related blindness.

PI_NAMEs: RAMAMURTHY, VISVANATHAN  (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: achromatopsia;Address;Affect;Anabolism;Animal Model;Animals;Aryl Hydrocarbon Receptor;Biochemical;Blindness;Catalytic Domain;Cell Transplantation;Childhood;Client;Clinical;Color blindness;Complex;Cone;Defect;design;Disease;Electrophysiology (science);Enzymes;Excision;Exhibits;farnesylation;Gene Transfer;Genes;geranylgeranylation;Goals;Growth Factor;Hand;Heat-Shock Proteins 90;Human;In Vitro;in vivo;Inherited;inhibitor;Intervention;isoprenylation;Knock-in;Knowledge;Lead;Light;Link;Lipids;Measurement;Mediating;Membrane;Modeling;Modification;Molecular;Molecular Chaperones;Monitor;Morphology;mouse model;Mus;mutant;Mutation;Neurons;novel;novel therapeutics;Pathway interactions;Patients;pharmacologic;Phenocopy;phosphodiesterase 6;phosphoric diester hydrolase;Photoreceptors;Phototransduction;Positioning Attribute;Post-Translational Protein Processing;prevent;programs;Protein Biosynthesis;receptor;Regulation;repaired;Research;response;Retina;Retinal Degeneration;Retinal Diseases;Retinal Photoreceptors;retinal rods;Retinitis Pigmentosa;Rod;Role;Signal Transduction;Stimulus;Testing;Therapeutic;Time;Tissue Transplantation;trafficking;transduction efficiency;treatment strategy;Vision;Visual

PROJECT_TITLE: Biosynthesis and trafficking of phosphodiesterase in the retinal photoreceptors

STUDY_SECTION: BVS

STUDY_SECTION_NAME: Biology of the Visual System Study Section[BVS]


NIH_SPENDING_CATS: Infectious Diseases;Sexually Transmitted Infections

ORG_DEPT: BIOCHEMISTRY

PHR: Project Narrative Herpesviruses infect the majority of the world’s human population by establishing lifelong latent infections that can periodically reactivate, causing a variety of ailments, including cold sores, blindness, encephalitis, and cancers, along with fatal conditions in newborns and the immunocompromised. The spread of infection relies on the ability of the virus to produce and release new infectious viral particles in a process termed nuclear egress and is the focus of this proposal. As there is no cure for herpesvirus infections, the goal of this proposal is to formulate a comprehensive mechanism as to how the nuclear egress complex, required for nuclear egress, mediates this process and determine how it can be inhibited to provide innovative routes for therapeutic approaches aimed at preventing the spread of infection.

PI_NAMEs: DRAGANOVA, ELIZABETH BENNETT (contact)

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: Affect;Automobile Driving;Binding;Biological Assay;Biology;biophysical techniques;Blindness;Capsid;career;Cell Nucleus;Cells;Cellular biology;Chemicals;Collaborations;Complex;Coupled;Coupling;Cryo-electron tomography;Cryoelectron Microscopy;Custom;Cytoplasm;Data;Data Analyses;Data Collection;Defect;design;Disease;Double Stranded DNA Virus;driving force;Drug Targeting;Encephalitis;Engineering;Ensure;Environment;Event;Experimental Designs;Future;Goals;Herpes Labialis;Herpes Simplex Infections;Herpesviridae;Herpesviridae Infections;Herpesvirus 1;Human;Immunocompromised Host;In Vitro;Individual;Infection;inhibitor;innovation;Institution;Instruction;Interferometry;Iowa;Knock-out;latent infection;light scattering;Malignant Neoplasms;Mammals;Mediating;Medical;medical schools;Membrane;Mentors;Methodology;Methods;Molecular Conformation;Monitor;mutant;Mutation;neonate;new therapeutic target;Newborn Infant;novel;Nuclear;Nuclear Inner Membrane;Outcome;particle;pathogen;peptide drug;Peptides;Pharmaceutical Preparations;Phase;Point Mutation;Population;post-doctoral training;prevent;Process;protein function;Protein Inhibition;protein protein interaction;Proteins;Qualifying;Research;Role;Route;screening;Series;small molecule;stem;Structure;Surface;Techniques;Testing;Therapeutic;therapeutic target;tomography;Universities;Viral;Viral Proteins;Virion;virology;Virus;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: Mechanisms of Conformational Dynamics and Inhibition of the HSV-1 Nuclear Egress Complex

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cardiovascular;Diabetes;Nutrition;Obesity;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: PROJECT NARRATIVE In response to obesity, cellular changes adipose tissue blood vessels can result in fibrosis or the pathological accumulation of scar tissue and worsening metabolic diseases. This project will identify pathways that regulate blood vessel cells to repress adipose tissue fibrosis and enhance beneficial fat cell expansion.

PI_NAMEs: LAYNE, MATTHEW D (contact)

PROGRAM_OFFICER_NAME: HAFT, CAROL R

PROJECT_TERMS: Actins;adipocyte differentiation;Adipocytes;Adipose tissue;Aorta;Biochemical;Blood Vessel Tissue;Blood Vessels;Carboxypeptidase;Cardiovascular Diseases;cardiovascular risk factor;Cells;Cicatrix;Collagen;Diabetes Mellitus;Diet;diet-induced obesity;Disease;Dyslipidemias;energy balance;Equilibrium;Event;Extracellular Matrix;Extracellular Matrix Proteins;Fat-Restricted Diet;fatty liver disease;Fibroblasts;Fibrosis;Functional disorder;gain of function;Growth Factor;High Fat Diet;Human;Hyperplasia;Hypertrophy;in vivo;Inflammation;Inflammatory;Injury;Insulin Resistance;Intervention;Kidney Diseases;Label;loss of function;Malignant Neoplasms;Maps;Measures;Metabolic;Metabolic Diseases;Metabolism;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ Culture Techniques;Outcome Study;Pathologic;Pathway interactions;Pericytes;Phenotype;phosphoproteomics;Platelet-Derived Growth Factor B;platelet-derived growth factor BB;Platelet-Derived Growth Factor beta Receptor;Platelet-Derived Growth Factor Receptor;Prevalence;prevent;Process;Production;progenitor;Protein Secretion;Proteins;Proteomics;Publishing;Recombinant Proteins;recruit;Regulatory Pathway;Reporter;Repression;Resolution;response;Series;Signal Induction;Signal Pathway;Signal Transduction;Signaling Protein;Smooth Muscle;Smooth Muscle Myocytes;stem cell differentiation;stem cells;Tertiary Protein Structure;Testing;Therapeutic Intervention;tissue injury;Tissues;Transforming Growth Factor beta;United States;Vascular Diseases;vascular injury;Vascular remodeling;Vascular Smooth Muscle

PROJECT_TITLE: Elucidating ACLP-dependent signaling pathways in the adipose tissue stromal-vascular niche

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Lung;Neurosciences;Physical Injury - Accidents and Adverse Effects;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Spinal cord injury is a devastating problem that affects about 300,000 people in the United States, with 17,000 new cases each year. The diaphragm muscle (DIAm) is the most important inspiratory muscle, and its role in breathing and/or airway protection is seriously impaired in many cases of cervical spinal cord injury (cSCI). The proposed studies will use two well established animal models of cSCI (C2 hemisection – C2SH and C4 contusion injury – C4CI) to provide exciting, new information on the role of brain-derived neurotrophic factor (BDNF) signaling through its high affinity receptor (TrkB) in the mechanisms underlying recovery of inspiratory function.

PI_NAMEs: MANTILLA, CARLOS B;SIECK, GARY C. (contact)

PROGRAM_OFFICER_NAME: LAPOSKY, AARON D

PROJECT_TERMS: Affect;Affinity;Alleles;Animal Model;Behavior;Brain-Derived Neurotrophic Factor;Breathing;Cervical spinal cord injury;Chronic;Complex;confocal imaging;Contusions;density;Development;experience;gamma-Aminobutyric Acid;Glutamates;Goals;Hydrogels;Impairment;In Situ Hybridization;Injury;innovation;insight;Ipsilateral;Knock-in;Label;Laboratories;loss of function;Mammals;Modeling;Morbidity - disease rate;mortality;Motor;Motor Neurons;mRNA Expression;Muscle;Muscle function;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neuron loss;Neuronal Plasticity;neuronal survival;neuroprotection;novel;novel therapeutic intervention;Patients;Persons;Phosphotransferases;Physiology;postsynaptic;preservation;pressure;presynaptic;Presynaptic Terminals;Rattus;receptor;receptor expression;Recovery;Recovery of Function;recruit;Reporting;Research;Research Personnel;Resolution;respiratory;Respiratory Diaphragm;Role;Signal Transduction;Site;Spinal Cord Contusions;Spinal cord injury;Structure of phrenic nerve;Synapses;Techniques;Time;Treatment Factor;United States

PROJECT_TITLE: Enhancing Respiratory Motor Function after Spinal Cord Injury

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Cystic Fibrosis;Diabetes;Lung;Pediatric;Rare Diseases

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: Project Narrative  Cystic fibrosis (CF)-related diabetes mellitus (CFRD) is a major predictor of worse lung function and affects ~20% of adolescents and >40% of adults with CF, even on highly effective CFTR modulators. This application will examine if metformin, a commonly used medication for diabetes, can improve the function of several ion channels important for mucus hydration in the airways and thus improve overall outcome of CF patients with abnormal glucose control.

PI_NAMEs: KIM, MICHAEL D;SALATHE, MATTHIAS A (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: 18 year old;Adolescent;Adult;Affect;Age;Agonist;Airway Disease;airway epithelium;airway surface liquid;blood glucose regulation;bronchial epithelium;Cells;Chronic;CLCA2 gene;Clinical;Clinical Trials;clinically relevant;cohort;Combined Modality Therapy;Continuous Glucose Monitor;Core-Binding Factor;Cystic Fibrosis;cystic fibrosis patients;cystic fibrosis related diabetes;Cystic Fibrosis Transmembrane Conductance Regulator;Data;data registry;Diabetes Mellitus;Dose;Double-Blind Method;Epidemiology;Epithelial Cells;Feedback;Ferrets;follow-up;Foundations;functional decline;Functional disorder;functional improvement;Glucose;glycemic control;HMGB1 gene;Hydration status;Hyperglycemia;improved;In Vitro;in vivo;Inflammation;Inflammatory;injured airway;Ion Channel;large-conductance calcium-activated potassium channels;Ligands;Link;Lung;MAP Kinase Gene;Measures;Mediating;Messenger RNA;Metformin;Molecular;mRNA Expression;Mucous body substance;mucus clearance;mutant;Mutate;Nose;Nuclear;Obstruction;Older Population;Outcome;p38 Mitogen Activated Protein Kinase;Pathogenesis;patient registry;Patients;Pattern;Pharmaceutical Preparations;Population;pre-clinical;preservation;Prevalence;Pulmonary Cystic Fibrosis;pulmonary function;pulmonary function decline;Pulmonary Function Test/Forced Expiratory Volume 1;Randomized;receptor;receptor for advanced glycation endproducts;Recovery;Reporting;Signal Pathway;Signal Transduction;soluble RAGE;Testing;Therapeutic Studies;Transcription Factor AP-1;translational study;voltage;VX-770

PROJECT_TITLE: Mechanisms of mucociliary dysfunction in cystic fibrosis related diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-K(03)]


NIH_SPENDING_CATS: Autoimmune Disease;Bioengineering;Biotechnology;Diabetes;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE Islet transplantation is a β-cell replacement therapy; however, 60-70% of islets are lost immediately following transplantation due to hypoxia, toxic metabolites from the liver, a pro-inflammatory environment and an instant blood-mediated inflammatory reaction (IBMIR). In this proposal, we will create a clinically translatable bioscaffold platform which combines multiple technologies that work together to provide sustained oxygen and nutrients to islets, while also restoring their bioenergetic profile via mitochondrial transfer from mesenchymal stem cells, until they can fully engraft and re-establish their own blood supply. Our studies will validate our technology at extra-vascular sites of transplantation and ensure there is no adverse inflammatory and foreign body reaction that will result in long term fibrosis, thereby paving the way for future clinical trials.

PI_NAMEs: THAKOR, AVNESH SINH (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: 3-Dimensional;Address;Alanine;Amino Acids;Anastomosis - action;Animal Model;Animals;Anti-Inflammatory Agents;beta cell replacement;Bioenergetics;bioscaffold;Blood;Blood Vessels;Bone Marrow;C57BL/6 Mouse;cell replacement therapy;Cells;clinical translation;Clinical Trials;Collagen;controlled release;cryogel;cytokine;Data;Dedications;diabetic;diabetic patient;Diffusion;Encapsulated;Engraftment;Ensure;Essential Amino Acids;exhaustion;Exhibits;extracellular vesicles;Fatty acid glycerol esters;Fibrosis;Foreign-Body Reaction;Future;Glutamine;glycemic control;Guidelines;Health;Human;Hypoxia;immunoregulation;implantation;Inflammatory;inflammatory milieu;Inflammatory Response;innovation;insulin secretion;islet;Islets of Langerhans Transplantation;Liver;Location;Mediating;Mesenchymal;Mesenchymal Stem Cells;Mitochondria;mouse model;Mus;nanoparticle;Nanotubes;novel;Nutrient;Omentum;Operative Surgical Procedures;Oxygen;Pancreas;paracrine;Portal vein structure;Process;progenitor;Reaction;response;revascularization;Secure;Silicon Dioxide;Site;Source;stem cells;Streptozocin;Stress;subcutaneous;Techniques;Technology;Testing;Therapeutic;Time;Transplantation;Vascular blood supply;Work

PROJECT_TITLE: A stem cell activated cryogel bioscaffold that restores islet bioenergetics while providing oxygen and nutrients at extravascular sites of transplantation


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Mental Health;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Peripheral Neuropathy;Substance Misuse

ORG_CITY: CHICAGO

ORG_DEPT: PHYSIOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Opioid addiction has been declared a public health crisis by the U.S. Department of Health and Human Services and more than 130 people in the United States die daily after overdosing on opioids. Chronic pain is a long-term disability that causes motivational-affective changes in the brain and about 21-29% of patients prescribed opioids for chronic pain misuse them. Investigating how pain changes motivational-affective brain circuitry and influences opioid addiction risk will help scientists and doctors devise treatments that consider affective-motivational aspects of pain to prevent future drug abuse.

PI_NAMEs: LOPEZ, GABRIELA CAROLINA (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;Acute Pain;addiction;Affective;Animal Model;anxious;approach behavior;Association Learning;Behavior;Behavioral;behavioral response;Biological;Brain;brain circuitry;chronic pain;chronic pain management;chronic painful condition;Cues;Data;Depressed mood;design;Dopamine;Drug abuse;Drug Addiction;Drug usage;Educational process of instructing;experience;experimental study;Extinction;Fentanyl;Fiber;Food;Functional disorder;Future;Goals;Grant;in vivo;Injury;Knowledge;Lead;Learning;Life;life span;Long term disability;Manuscripts;Measures;Mediating;Mental Depression;Mentorship;Minority-Serving Institution;Modeling;Mood Disorders;Motivation;mouse model;Mus;National Institute of Drug Abuse;National Research Service Awards;negative affect;nerve injury;neural;Neurobiology;Nose;Nucleus Accumbens;Operant Conditioning;Opiate Addiction;Opioid;optogenetics;oral communication;Outcome;Overdose;Pain;pain chronification;pain model;painful neuropathy;Patients;Persons;Pharmacotherapy;Photometry;Postdoctoral Fellow;Predisposition;prescription opioid;prevent;Psychological reinforcement;Public Health;Research Personnel;Rewards;Risk;Role;rumination;Scientist;sham surgery;Signal Transduction;spared nerve;Sucrose;Testing;Thinking;Training;United States;United States Dept. of Health and Human Services;vapor;Ventral Tegmental Area;Writing

PROJECT_TITLE: Chronic Pain Modulation of Mesolimbic Dopamine Signaling for Natural and Opiate Rewards


ADMINISTERING_IC: TR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: Project Narrative: The overall goal of this proposal is to accelerate advances in human health by engaging multiple stakeholders in the translation of scientific discoveries to drive improvements in health and reduce inequity among diverse populations. Our proposal will improve clinical research through high quality and efficient methods/processes, develop a trained workforce skilled in team science, and disseminate research findings into real-world implementation to improve health and healthcare for patients, our diverse communities, and our nation. Project Narrative Page 236

PI_NAMEs: POWDERLY, WILLIAM G. (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Acceleration;Address;Adopted;Advocate;Affect;archived data;base;Biological;Biometry;Clinic;Clinical;Clinical and Translational Science Awards;clinical practice;Clinical Research;Clinical Sciences;Clinical Trials;Collaborations;Communities;community engagement;Community Health;Complex;Conceptions;data integration;Data Set;Development;digital;Disease;Dissemination and Implementation;dissemination science;diverse data;Ecosystem;Education;education research;Elderly;Ensure;Faculty;fundamental research;Genomics;Goals;Health;health difference;health disparity;health inequalities;Healthcare;Healthcare Systems;Home;Human;Illinois;implementation design;implementation science;improved;Individual;Industry;Inequity;Informatics;informatics tool;Infrastructure;innovation;Institution;inter-institutional;Interdisciplinary Study;interoperability;Intervention;Knowledge;Laboratories;Life;life span;Mentors;Methodology;Methods;Missouri;Multi-Institutional Clinical Trial;multidisciplinary;multiscale data;Outcome;Participant;Patient Care;Patients;Population;Population Heterogeneity;Process;Productivity;programs;Qualifying;Research;Research Personnel;Resources;rural environment;Rural Population;Science;skills;social determinants;Socioeconomic Factors;Special Population;Target Populations;Technology;Time;Training;Training Programs;Translating;translational impact;Translational Research;Translations;Universities;Urban Population;urban setting;Washington;Work;Workforce Development

PROJECT_TITLE: Washington University Institute of Clinical and Translational Sciences


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dementia;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Neurodegenerative;Social Determinants of Health

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: PROJECT NARRATIVE Many older adults living in nursing homes experience loneliness or social isolation. The impact of social isolation on the health and well-being of nursing home residents needs to be better understood. The COVID-19 pandemic restricted visitors to the homes and socializing within nursing homes. This study will examine the extent to which social isolation occurs in nursing homes, how it impacts health and well-being, and what factors may reduce social isolation and increase social connectedness.

PI_NAMEs: LAPANE, KATE L (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Address;Adult;advanced analytics;Affect;Aggressive behavior;Aging;Alzheimer's disease related dementia;Anxiety;Area;Attenuated;Behavioral Symptoms;Caring;Cessation of life;Characteristics;Cognitive;Communication;Communities;contagion;contextual factors;Coupled;COVID-19;COVID-19 impact;COVID-19 pandemic;COVID-19 pandemic effects;Crowding;Data;Data Set;Data Sources;Dementia;design;Development;Elderly;Eligibility Determination;Emotional;Environment;ethnic segregation;Evaluation;Evolution;experience;Facial Expression;functional status;Funding;Goals;Health;health determinants;Healthcare Systems;Heart Diseases;Home;Hospitalization;Hypertension;Impaired cognition;indexing;Individual;Intervention;knowledge base;Link;Loneliness;Long-Term Effects;Longitudinal Studies;loved ones;Measures;Medicare;Mental Depression;National Institute on Aging;Natural experiment;neglect;novel;nursing home length of stay;Nursing Homes;older adult;Outcome;pandemic disease;pandemic impact;pandemic preparedness;Pattern;Personal Satisfaction;Persons;Pharmaceutical Preparations;Physical Function;Policies;Population;Posture;Process;Quality of Care;Race;Research;Risk;social;Social isolation;Social Network;social vulnerability;Socialization;Societies;Strategic Planning;Stroke;Testing;Underserved Population;United States;United States National Institutes of Health;virtual;Work

PROJECT_TITLE: Social Connectedness and Social Isolation in Nursing Home Residents


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences

PHR: NARRATIVE Retinal pigment epithelial (RPE) cells have a unique metabolism that is altered in retinal degenerative diseases. Findings from our studies will provide fundamental knowledge for what RPE needs for its survival and function, and advance the understanding of the underlying causes of retinal diseases. 1

PI_NAMEs: DU, JIANHAI  (contact)

PROJECT_TERMS: Age related macular degeneration;Amino Acids;Anabolism;Atrophic;Blindness;Catabolism;Cells;Choroid;Citric Acid Cycle;Clinical;Collagen;Communication;Consumption;Data;Disease;Elderly;Electron Microscopy;Electroretinography;Enzyme-Linked Immunosorbent Assay;Enzymes;Epithelium;extracellular;Fatty Acids;Foundations;genetic signature;Glucose;glucose metabolism;Goals;Health;Homeostasis;Human;Image;Immunohistochemistry;Impairment;In Vitro;in vivo;Infusion procedures;Knock-out;Knockout Mice;Knowledge;Link;macula;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolic Pathway;Metabolism;metabolomics;meter;Methodology;Mitochondria;mitochondrial metabolism;Modeling;monolayer;mouse model;Mus;Mutation;NADP;Nitrogen;novel;novel therapeutics;Nutrient;Nutritional Requirements;Nutritional Support;Optical Coherence Tomography;Outcomes Research;oxidation;Pathogenesis;Pathway interactions;Phagocytosis;Photoreceptors;Play;Production;programs;Proline;proline permease;Property;Publications;Retina;retinal damage;Retinal Degeneration;Retinal Diseases;risk variant;Role;sensor;Structure of retinal pigment epithelium;Support Groups;Testing;Thick;tissue culture;Tracer;Vascular blood supply;Vision;Visual impairment;Western Blotting

PROJECT_TITLE: Proline metabolism in retinal health


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: NARRATIVE Despite evidence pharmacy closures disproportionately affect predominately Black and Hispanic neighborhoods, and Medicare Part-D policies and practices are a fundamental cause of such closures, the impact of pharmacy closures on persistent disparities in medication adherence among older adults is not known. The proposed project will evaluate the extent and impact of pharmacy closures on medication adherence among chronically ill Medicare Part-D beneficiaries and identify subgroups most at-risk for non-adherence post-closure. Our findings will contribute new evidence that policymakers need to advance equitable, and eliminate discriminatory, policies with Part-D and resolve persistent disparities in medication adherence.

PI_NAMEs: QATO, DIMA MAZEN (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Address;Adherence;adherence rate;Adrenergic beta-Antagonists;adverse outcome;Affect;Anti-diabetic Drugs;beneficiary;Black Populations;Black race;Bronchodilator Agents;Censuses;Characteristics;Chronic;Chronically Ill;Communities;community barrier;Community Participation;Complex;copayment;County;COVID-19 pandemic;Data Set;Data Sources;Development;Dimensions;Disparity;disparity reduction;Drug Prescriptions;dual eligible;Emergency Care;Equity;ethnic disparity;Ethnic Origin;Exclusion;Exposure to;Funding;Gender;Geography;Goals;Growth;Hispanic;Hispanic Populations;Home;Hour;human old age (65+);Improve Access;Individual;innovation;insight;Investigation;Knowledge;Link;Location;Mail Order;Measures;Medicare;medication compliance;Minority;Monitor;multilevel analysis;Neighborhoods;novel;older adult;Outcome;outcome disparities;Ownership;Pathway interactions;Patients;payment;Pharmaceutical Preparations;Pharmaceutical Services;Pharmacy facility;Policies;Policy Maker;Poverty;Prevention;Preventive care;programs;Public Health;Quasi-experiment;Race;racial disparity;Reduce health disparities;Regulation;Research;Research Design;residential segregation;Resources;Risk;Role;Rural Community;segregation;Series;Service provision;Structural Racism;Subgroup;theories;Urban Community;Urbanicity;Work

PROJECT_TITLE: Structural Racism, Pharmacy Closures and Disparities in Medication Adherence Among Older Adult Medicare Part-D Beneficiaries

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-G(90)S]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Brain Disorders;Mental Health;Mental Illness;Pediatric

ORG_DEPT: PSYCHIATRY

ORG_NAME: WASHINGTON UNIVERSITY

PHR: The proposed renewal application seeks to build upon the past success of the currently NIMH R25 funded Psychiatry Residency Research Education Program (PRREP). The goal of PRREP is to enhance the recruitment and training of psychiatrists for a career in academic psychiatry in order to meet the increasing shortage of physicians who conduct research in mental health and mental disorders. Training will focus on basic neuroscience, clinical science, imagining, genetics, public health, and epidemiology but can be in any area that impacts mental health and illness.

PI_NAMEs: FARBER, NURI B (contact);SPIEGEL, TIMOTHY ERIC

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adolescent Psychiatry;Adult;African American;Area;Award;Budgets;career;Categories;Child Psychiatry;Clinical Sciences;clinical training;Data Collection;design;disabled;Doctor of Philosophy;early-career faculty;Education;education planning;Education Projects;education research;Epidemiology;expectation;experience;Exposure to;Faculty;Feedback;Fellowship;Female;Foundations;Funding;Future;Genetic;Goals;Grant;hands on research;Hispanic;Individual;innovation;Institution;interest;Journals;K-Series Research Career Programs;Knowledge;Manuscripts;Medicine;meetings;Mental disorders;Mental Health;Mentors;Mentorship;National Institute of Mental Health;Neurosciences;next generation;Phase;Physicians;Positioning Attribute;Post Graduate Year;Principal Investigator;Productivity;programs;Psychiatrist;Psychiatry;Public Health;Publications;recruit;Reporting;Research;Research Design;Research Personnel;Research Training;Residencies;Resources;Scientist;skill acquisition;skills;Solid;Structure;success;Targeted Research;Time;Training;Training Programs;Translational Research;Travel;United States National Institutes of Health;Universities;Vocational Guidance;Washington;workforce needs;working group

PROJECT_TITLE: Washington University Psychiatry Residency Research Education Program


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Chronic Pain;Genetics;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: BIDDEFORD

ORG_NAME: UNIVERSITY OF NEW ENGLAND

ORG_STATE: ME

PHR: PROJECT NARRATIVE Over 25 million American adults live with persistent pain, contributing to their worsened health, disability and use of health care services. New strategies are urgently needed to understand the basic mechanisms, and develop non-opioid interventions. This project will investigate RNA-protein interactions in sensory neurons as a mechanism for the generation of persistent pain and determine if targeting these interactions is a viable future strategy for the development of a new class of therapeutics. Experiments will expand our basic knowledge of how the biosynthetic machinery within pain sensing neurons responds to tissue injuries and inflammation, and how these processes become dysregulated in pre-clinical models of chronic pain.

PI_NAMEs: HARRISON, BENJAMIN  (contact)

PROGRAM_OFFICER_NAME: MOHAPATRA, DURGA PRASANNA

PROJECT_TERMS: Acute;Adult;Afferent Neurons;American;Animal Model;animal pain;antinociception;Attenuated;Behavioral;Binding;Binding Proteins;Biological Assay;Capsaicin;Carrageenan;Cells;chronic pain;chronic painful condition;Clinical;clinical pain;cohort;Complex;Computer Analysis;Crush Injury;Data;Data Set;Development;disability;Dissociation;efficacy testing;electrical property;experimental study;Family;Future;gain of function;Generations;Genes;Genetic;Health;health care service utilization;heat stimulus;Histologic;Hyperalgesia;Hypersensitivity;in silico;in vivo;Inflammation;Inflammatory;inflammatory pain;Injury;Intervention;Investigation;Ion Channel;Ion Channel Protein;Knock-out;Knockout Mice;Knowledge;loss of function;Mass Spectrum Analysis;Measures;mechanical stimulus;Mechanics;member;Messenger RNA;Minor;Modeling;mouse model;mRNA Translation;Mus;nerve injury;neuronal excitability;Neurons;Neuropeptides;neurotransmission;new therapeutic target;Nociception;Nociceptors;non-opioid analgesic;novel;novel therapeutics;overexpression;Pain;pain chronification;pain model;pain perception;Pain Threshold;painful neuropathy;patch clamp;patient subsets;Persistent pain;pharmacologic;pre-clinical;Pre-Clinical Model;preference;Process;Protein Biosynthesis;Proteins;Proteomics;Regulon;Reporting;response;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;Sampling;sciatic nerve injury;Sensory;sex;single cell analysis;single-cell RNA sequencing;Spinal Ganglia;Stimulus;Syndrome;Testing;Therapeutic;Therapeutic Intervention;tissue injury;tool;trafficking;Transcript;Translating;translating ribosome affinity purification and RNA-sequencing;Translational Repression;Translations;transmission process;Treatment Efficacy;Viral;Viral Vector;Western Blotting

PROJECT_TITLE: RNA-Protein Interactions in Nociception

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Congenital Heart Disease;Congenital Structural Anomalies;Data Science;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Rare Diseases

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Medical imaging is critical to almost every type of diagnostic and management decision, but human interpretation of medical images can lack accuracy and reproducibility. By developing machine learning methods for analyzing medical images, the work in our proposal can improve diagnostic accuracy in medical imaging, for both clinical and research uses.

PI_NAMEs: ARNAOUT, RIMA  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Abdomen;Address;Adult;Apical;Artificial Intelligence;Biometry;Birth;Cardiac;Cardiovascular Diseases;cardiovascular imaging;Cardiovascular system;Classification;Clinical;clinical center;clinical decision-making;clinical imaging;Clinical Research;clinical translation;clinically relevant;Collection;Communities;comorbidity;Complex;computerized data processing;Congenital Abnormality;congenital heart abnormality;cost;Data;data curation;data harmonization;Data Science;Data Set;deep learning;deep learning algorithm;deep learning model;Democracy;design;Detection;detection test;Diagnosis;Diagnostic;diagnostic accuracy;Early Diagnosis;Early treatment;Echocardiography;Environment;Evaluation;Face;fetal;fetal diagnosis;Fetal Heart;Goals;Heart;Heart Abnormalities;heart disorder diagnosis;heart imaging;Human;Image;Image Analysis;image guided;image processing;imaging study;improved;Informatics;insight;Label;learning network;Lesion;Life;Literature;Machine Learning;machine learning algorithm;machine learning method;Measurement;Medical Imaging;Methods;model design;Modeling;Morbidity - disease rate;mortality;multidisciplinary;multimodality;neural network;neural network architecture;novel;Outcome;patient population;Patients;Pattern;Pattern Recognition;Performance;Phenotype;Physicians;Population;precision medicine;Pregnant Women;prenatal;prevent;programs;Provider;Psyche structure;Quality Control;Rare Diseases;Recommendation;repaired;Reproducibility;Research;screening;Secure;standard of care;statistics;Structure;Surveys;Techniques;Testing;theories;Time;tool;Trachea;Training;Translating;Ultrasonography;ultrasound;Variant;Work

PROJECT_TITLE: Improving cardiovascular image-based phenotyping using emerging methods in artificial intelligence

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Understanding intracellular protein degradation is a key goal of basic research, with applications in biotechnology and medicine. Enzymes of the AAA+ family clear the cell of toxic proteins and carry out many other ATP-dependent cellular processes needed to promote health and prevent disease. Our studies will illuminate molecular mechanisms employed by a specific AAA+ protease, ClpXP, and shed light on the entire enzyme superfamily.

PI_NAMEs: SAUER, ROBERT T (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: Antibiotics;ATP Hydrolysis;ATP phosphohydrolase;ATP-Dependent Proteases;Basic Science;Biochemical;Biotechnology;C-terminal;Cell Physiology;Cells;Coupled;Defect;Disease;Ensure;Enzymes;Escherichia coli;Exclusion;experimental study;Family;Goals;Growth;Health Promotion;hearing impairment;heme biosynthesis;Infertility;Mammals;Mechanics;Medicine;Mitochondria;Molecular;Mycobacterium tuberculosis;N-terminal;Pathogenesis;Peptide Hydrolases;Play;polypeptide;Positioning Attribute;prevent;protein degradation;protein folding;Proteins;Role;Rotation;Specificity;Structure;Time;Work

PROJECT_TITLE: Structure and function of ClpXP

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]