NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE The hospital to skilled nursing facility (SNF) care transition for older adults remains persistently medicalized, failing to be guided by patients’ own preferences for their recovery, and does not incorporate elements that support preferences related to independence, returning home and function, or factors that allow participation in family or community activities that provide a foundation for personal purpose. The objective of this proposal is to develop and test a SNF preparation tool (SNF-PT) that facilitates communication and implementation of patient preferences into SNF transition plans. Ultimately, the information learned from this proposal will lead to the development of interventions to improve the care transition outcomes and experiences of older adults discharged from the hospital to SNFs.

PI_NAMEs: HARRISON, JAMES DAVID (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: acceptability and feasibility;Adopted;Aging;American;aspirate;Behavior;California;care delivery;career;Caregivers;Caring;Clinical;Collaborations;Communication;Communities;Creativeness;Data;design;Elements;Ensure;Ethnography;expectation;experience;Family;Foundations;Future;Geriatrics;Goals;Health care facility;health communication;Health system;Home;hospital readmission;Hospitalization;Hospitals;human centered design;human old age (65+);Impairment;implementation evaluation;implementation outcomes;implementation science;implementation strategy;implementation tool;improved;improved outcome;Individual;innovation;Institutional Practice;Intervention;Interview;leadership development;Learning;Medical;Mentored Research Scientist Development Award;Mentors;Mentorship;Methods;older adult;Outcome;Participant;Patient Discharge;patient engagement;patient oriented;Patient Preferences;Patient-Focused Outcomes;Patients;Perception;person centered;Pharmaceutical Preparations;Phase;pilot test;post implementation;preference;Preparation;Process;professor;programs;Prospective Studies;Provider;provider communication;Qualitative Research;Recovery;Research;research and development;Research Methodology;Research Personnel;San Francisco;satisfaction;Scientist;Series;Skilled Nursing Facilities;skills;Techniques;Testing;theories;therapy development;Time;tool;Training;Trust;Universities;user centered design;Vision;Voice;Work

PROJECT_TITLE: Placing patient preferences at the center of care plans for older adults transitioning from the hospital to a skilled nursing facility

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ADMINISTERING_IC: HG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Data Science;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Los Angeles

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This project aims to provide a complete and integrated picture of what every single gene in a human being does, thus allowing us to better understand the genetic and cellular workings of human health and disease. We do this by developing the Gene Ontology, a computational resource that collects biological knowledge into a large network structure that connects genes with the roles they play. Researchers, clinicians, and sophisticated computer programs use this network to interpret the massive amounts of biomedical and genomic data being generated in experiments and in studies designed to gain key insights into human health.

PI_NAMEs: MUNGALL, CHRISTOPHER J;STERNBERG, PAUL WARREN;THOMAS, PAUL D. (contact)

PROGRAM_OFFICER_NAME: FLETCHER, COLIN F

PROJECT_TERMS: Adoption;Area;Automation;Basic Science;big biomedical data;Bioinformatics;Biological;Biological Process;biological research;Biological Sciences;biological systems;Biology;biomedical ontology;Biomedical Research;Communities;community engagement;Complex;computational reasoning;Computer Analysis;computer based Semantic Analysis;computer infrastructure;Computer Models;computer program;Computers;computing resources;Data;Data Set;Databases;design;Development;Disease;Ensure;Environment;evidence base;experimental study;flexibility;Foundations;Gene Family;gene function;gene network;Genes;Genetic;genome resource;genomic data;Genomics;Goals;Health;Human;Human Biology;human disease;Improve Access;improved;Information Resources;Infrastructure;Ingestion;insight;interoperability;Knowledge;knowledgebase;learning community;Link;Machine Learning;machine learning method;Maps;Measurement;Medical Research;meetings;migration;Modeling;Modernization;molecular scale;Natural Language Processing;Ontology;ontology development;outreach;Pathway Analysis;Pathway interactions;Pattern;Persons;Play;Procedures;Process;Provider;Reproducibility;Research;Research Design;Research Personnel;Resources;Rhea;Role;Semantics;social media;Source;Standardization;Structure;Techniques;Technology;Testing;text searching;tool;Training;training data;Update;usability;web services;Work

PROJECT_TITLE: Gene Ontology Consortium and Knowledgebase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-T(55)R]


ADMINISTERING_IC: NS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Precision Medicine;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK GENOME CENTER

ORG_STATE: NY

PHR: Amyotrophic lateral sclerosis (ALS) and Frontotemporal Dementia (FTD) are part of a devastating neurodegenerative disease spectrum for which there are no biomarkers and only limited treatments, stemming from a poor understanding of its pathogenesis. Here, we propose to integrate novel computational methods with spatially resolved transcriptomic and proteomic analyses of clinically deep-phenotyped post-mortem ALS-FTD brains to determine the specific molecular underpinnings of functional impairment in this disease. By integrating our analysis across different types of data (single cell RNA-seq, spatial transcriptomics, multiplexed imaging and proteomics), our ultimate goal is to unveil how disease-associated pathology is linked to dysfunction in specific cell types in ALS-FTD, which may in turn foster precision medicine-based treatment strategies.

PI_NAMEs: JACKSON, CHRISTOPHER ;PHATNANI, HEMALI  (contact)

PROGRAM_OFFICER_NAME: GUBITZ, AMELIE

PROJECT_TERMS: Adopted;Affect;Age;ALS patients;Amyotrophic Lateral Sclerosis;Atlases;Autopsy;Behavioral;Biological Markers;Brain;Brain region;Brodmann's area;burden of illness;Cell Communication;cell type;Cells;Central Nervous System;Clinic;Clinical;clinical predictors;clinical subtypes;Cognitive;cognitive change;Cognitive deficits;cognitive function;cognitive testing;cohort;computational pipelines;computer framework;Computing Methodologies;Data;data acquisition;data integration;Disease;Event;Fostering;frontal lobe;Frontotemporal Dementia;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Functional impairment;Gender;Gene Expression;Gene Expression Profile;Goals;Heterogeneity;high dimensionality;Histology;Image;immune imaging;Impaired cognition;Indirect Immunofluorescence;Individual;Link;Maps;Measurement;Measures;Methods;MFGE8 gene;Modality;Molecular;Motor;motor disorder;multimodality;multiple omics;multiplexed imaging;Neurodegenerative Disorders;neuropathology;neurotoxic;new therapeutic target;North America;novel;novel diagnostics;Outcome;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Population;precision medicine;Prefrontal Cortex;protein aggregation;protein TDP-43;Proteins;Proteome;Proteomics;regional difference;Resolution;Sensitivity and Specificity;single-cell RNA sequencing;spatial integration;Spinal Cord;Statistical Models;stem;Sudden Death;TDP-43 aggregation;Testing;Tissue Sample;Tissues;transcriptome;transcriptomics;treatment strategy;Work

PROJECT_TITLE: Integrating Spatial Multi-omics and Clinical Covariates to Identify Mechanisms of Disease in ALS-FTD

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: MADISON

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Project Narrative Understanding how cells attach to one another and move between one another is important for understanding many common birth defects, and many of the same processes that are tightly regulated in embryos are misregulated in cancer cells as they lose their connections to one another and invade the body. This proposal examines how actin – a protein essential for cell movements – works alongside proteins that regulate cell adhesiveness to build strong connections between cells and to help them avoid injury, and how signals regulate the actin machinery that allows cells to change position in the embryo.

PI_NAMEs: HARDIN, JEFFREY D (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Actins;Adherens Junction;Adhesiveness;alpha catenin;Area;Biological Models;Biophysics;Cadherins;Caenorhabditis elegans;cancer cell;cell motility;Cells;Complex;Congenital Abnormality;Cytoskeleton;Embryo;Embryonic Development;Epithelial Cells;Epithelium;Event;F-Actin;Genetic;healing;Human;Human Development;human disease;in vivo evaluation;Injury;insight;Intercalated Cell;Invaded;LIM Domain;Malignant Neoplasms;mechanotransduction;Modeling;Morphogenesis;Motility;Movement;multidisciplinary;novel;Organism;Pathway interactions;polymerization;Polymers;Positioning Attribute;prevent;Process;Proteins;recruit;Regulation;Self-Injurious Behavior;Signal Pathway;Signal Transduction;single molecule;Testing;Work

PROJECT_TITLE: Regulation of dynamic actin networks during epithelial morphogenesis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Defects in developmental timing underlie many human diseases and inherited disorders. A better understanding of the fundamental mechanism of developmental timing, and the role of miRNAs in this process, is essential for developing therapies for these problems.

PI_NAMEs: POETHIG, RICHARD SCOTT (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Address;Adolescent;Adult;Alleles;Arabidopsis;Biological;Biological Process;Buffers;Defect;Development;developmental plasticity;Down-Regulation;Evolution;experimental study;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic analysis;Genetic Screening;genome sequencing;Hereditary Disease;human disease;insight;Laboratories;Lead;loss of function mutation;Maps;Measures;Mediating;MicroRNAs;Molecular;Morphology;Mouse-ear Cress;mutant;Mutation;mutation screening;Nature;novel;Organ;Organism;Pattern;phase change;Phenotype;Plant Leaves;Plants;Population;Post-Transcriptional Regulation;Process;Production;Quantitative Trait Loci;Regulation;Reporter;Repression;Research;Resources;response;reverse genetics;Role;segregation;Source;System;Testing;therapy development;Time;trait;transcription factor;Transgenic Organisms;Variant;whole genome

PROJECT_TITLE: Genetic analysis of a developmental clock in Arabidopsis

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Genetics;Muscular Dystrophy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: RICHMOND

ORG_DEPT: NEUROLOGY

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Limb girdle muscular dystrophy R1 (LGMDR1) is a common muscular dystrophy due to loss of function of a muscle structural gene called CAPN3, which causes progressive weakness and disability, has no treatments, but is amenable to approaches to gene replacement therapy or therapies with other muscle therapeutics. Validating a robust measure of muscle function and a measure of muscle composition (muscle fat fraction) will help the LGMDR1 community prepare for forthcoming clinical trials and ensure the clinical trials do not reject potentially useful drugs due to poor planning or lack of robust clinical outcome tools. We propose to validate the NSAD and quantitative muscle MRI by performing a 24-month study of 100 individuals with LGMDR1 at 12 sites in an existing LGMD Clinical Research Network to help hasten therapeutic development.

PI_NAMEs: JOHNSON, NICHOLAS ELWOOD (contact)

PROGRAM_OFFICER_NAME: GARCIA, LINA FERNANDA

PROJECT_TERMS: Address;Advocacy;Affect;Area;autosome;Biological Markers;burden of illness;Characteristics;Clinical;clinical development;clinical outcome assessment;Clinical Research;Clinical Trials;Collaborations;Communities;Dependovirus;Development;disability;Disease;disease model;Disease Progression;Duchenne muscular dystrophy;Ensure;Europe;European;Exclusion Criteria;Fatty acid glycerol esters;FDA approved;Follow-Up Studies;functional outcomes;functional status;Future;Gene Delivery;gene replacement therapy;gene therapy;gene-targeted therapy;Genes;Goals;Hip region structure;Individual;Industry Collaboration;Limb Development;Limb structure;Limb-Girdle Muscular Dystrophies;Longitudinal Studies;Longitudinal, observational study;loss of function;Lower Extremity;Lung;Magnetic Resonance Imaging;Measures;Medical;meter;Methods;Monitor;Motor;Muscle;muscle form;Muscle function;muscle strength;Muscular Dystrophies;Natural History;Nature;Occupations;Outcome;Outcome Measure;Participant;Patient Outcomes Assessments;Patients;Performance;Pharmaceutical Preparations;Phase;Phenotype;Population;preclinical development;primary endpoint;primary outcome;prospective;Readiness;Regenerative Medicine;regression trees;Reporting;Research;Research Personnel;Running;Sample Size;Shoulder;Signal Transduction;Site;Spinal Muscular Atrophy;standard measure;Standardization;Structural Genes;Subgroup;Technology;Testing;Therapeutic;therapeutic development;Therapeutic Trials;Time;tool;Training;trial readiness;Upper Extremity;Validation;Visit;Walking

PROJECT_TITLE: Trial Readiness and Endpoint Assessment in LGMDR1 (TREATing-LGMDR1)


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: OVERALL PROJECT NARRATIVE The UCLA Jonsson Comprehensive Cancer Center (JCCC) strategic mission is to accelerate discoveries that prevent and cure cancer. Through a deep and broad spectrum of impactful research endeavors, clinical and research education and training programs, and the highest quality of patient care in multiple academic and community settings, the JCCC seeks to reduce the burden of cancer throughout its Los Angeles County catchment area and the nation.

PI_NAMEs: TEITELL, MICHAEL A (contact)

PROGRAM_OFFICER_NAME: HE, MIN

PROJECT_TERMS: Acceleration;Address;anti-cancer research;Applications Grants;Area;Biomedical Engineering;Breast Cancer survivor;Cancer Burden;cancer cell;Cancer Center Support Grant;Cancer Control;cancer education;Cancer Patient;cancer prevention;cancer risk;Cancer Survivorship;care delivery;career;career development;Caring;Catchment Area;Cell Therapy;Cells;Clinical;Clinical Research;Clinical Sciences;Clonal Evolution;colorectal cancer screening;Communication;Communities;community engagement;Community Outreach;community partners;community setting;Complement;Comprehensive Cancer Center;County;dashboard;Detection;Diagnostic;Early Diagnosis;Education;education research;Educational workshop;Electronic cigarette;electronic cigarette use;Environment;Epigenetic Process;epigenomics;ethnic minority population;Event;Evolution;Faculty;FDA approved;Fellowship Program;fighting;first-in-human;follow-up;Fostering;Gene Expression Regulation;Genetic;Grant;Guidelines;Healthcare;Immigrant;Immune;Immune response;Immune system;Immunotherapy;improved;Individual;infection related cancer;innovation;Institution;Intervention Studies;Laboratories;Leadership;Learning;Lesion;Los Angeles;Low income;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant Neoplasms;member;Mentors;Metabolic;metastatic process;Mission;molecular imaging;Nanotechnology;Neoplasm Metastasis;Obesity;Occupations;Organizational Change;Patient Care;patient oriented;Patients;Population Sciences;Postdoctoral Fellow;premalignant;prevent;Prevention;Prevention strategy;programs;prospective;Recurrence;Research;Research Personnel;Resource Sharing;Risk;RNA;Scientist;screening;Signal Transduction;Sleeplessness;stem;stem cell biology;Strategic Planning;survivorship;targeted treatment;theranostics;Therapeutic;Training;Training Activity;Training and Education;Training Programs;translational research program;treatment and outcome;tumor;tumor heterogeneity;tumor immunology;Uncertainty;United States National Institutes of Health;Vaccination;Vision;Writing

PROJECT_TITLE: Cancer Center Support Grant

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Cancer

PI_NAMEs: FITZMAURICE NELIGAN, MELISSA  (contact)

PROJECT_TERMS: Achievement;Area;Businesses;Cancer Center;Cancer Center Support Grant;cancer education;cancer research center director;Clinical;Collaborations;Communication;community engagement;Community Outreach;Comprehensive Cancer Center;Data;Evaluation;Event;Fostering;Human Resources;Informatics;Information Technology;Infrastructure;Malignant Neoplasms;meetings;member;Mission;Occupational activity of managing finances;Office of Administrative Management;operation;Operations Research;Productivity;programs;Reporting;Research;Research Support;Resource Allocation;Resource Sharing;Science;Services;Strategic Planning;Training and Education;Update;web site

PROJECT_TITLE: Cancer Center Administration


PI_NAMEs: ST. JOHN, MAIE A. (contact)

PROJECT_TERMS: Acceleration;Adult;Ally;anti-cancer research;Area;Award;Basic Science;Biomedical Research;Businesses;Cancer Center Support Grant;Cancer Control Research;cancer education;career;career development;Catchment Area;Child;Clinical;Clinical Cancer Center;clinical care;Clinical Research;Clinical Sciences;Clinical Trials Network;Communities;Complement;Comprehensive Cancer Center;computer science;County;Creativeness;Development;Discipline;Doctor of Philosophy;Ecosystem;Education;education research;Educational Activities;educational atmosphere;Educational process of instructing;Engineering;Faculty;Family;Fellowship Program;Fostering;Foundations;Goals;Health Benefit;Health Professional;Humanities;innovation;Institution;interest;Knowledge;Left;Los Angeles;Malignant Neoplasms;Mentors;Mentorship;Minority;Mission;next generation;Oncology;Patients;peer;Population;Population Sciences;Preparation;programs;Research;Research Personnel;Research Training;Resource Allocation;Resources;scaffold;Science;Scientist;Solid;Strategic Planning;Teaching Hospitals;Training;Training Activity;Training and Education;Training Programs;Translational Research;Underrepresented Populations;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Cancer Research Career Enhancement and Related Activities


NIH_SPENDING_CATS: Cancer;Patient Safety

PI_NAMEs: LI, GANG  (contact)

PROJECT_TERMS: Adherence;Amendment;anti-cancer research;Applications Grants;Area;Award;Basic Science;Bioinformatics;biomathematics;Biometry;Cancer Center;Cancer Center Support Grant;cancer clinical trial;Catchment Area;Child;Clinical;Clinical Cancer Center;Clinical Data;clinical practice;clinical trial analysis;clinical trial implementation;clinical trial protocol;Clinical Trials;Clinical Trials Data Monitoring Committees;Collaborations;Community Clinical Oncology Program;Comprehensive Cancer Center;County;Data;data acquisition;Data Analyses;data management;design;Direct Costs;Doctor of Philosophy;Education;Educational workshop;Ensure;Epidemiology;Evaluation;Faculty;Funding;gang;Goals;graduate student;Health Sciences;high dimensionality;Hospitals;Informatics;Institution;International;Journals;Los Angeles;Malignant Neoplasms;Manuscripts;Medical;Medicine;meetings;member;Methodology;Mission;Monitor;NCI Center for Cancer Research;next generation;novel;Oncology;Peer Review;Population;Population Study;Preparation;professor;programs;protocol development;Protocols documentation;Publications;Recurrence;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;response;Review Committee;Role;Services;Site;Statistical Data Interpretation;Statistical Study;statistics;timeline;Training;Translational Research;Woman

PROJECT_TITLE: Biostatistics, Analytical Support and Evaluation Shared Resource (BASE)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE – CENTER OVERVIEW The mission of the Diabetes Research and Training Center is to promote new discoveries and enhance scientific progress by supporting cutting-edge basic and clinical research on the etiology of diabetes and its complications with the goal of rapidly translating research findings into novel strategies for the diagnosis prevention, treatment and cure of diabetes and related conditions. The Center provides strategic vision, cutting-edge, high quality and cost-effective services and resources, and gives opportunity to current and next generation scientists to fluorish in a highly collaborative and productive environment.

PI_NAMEs: BELL, GRAEME I;MIRMIRA, RAGHAVENDRA G (contact)

PROGRAM_OFFICER_NAME: LYNCH, CHRISTOPHER

PROJECT_TERMS: American;Area;Awareness;base;Basic Science;bench to bedside;Biomedical Research;Cellular biology;Chicago;Clinical;Clinical Research;Collaborations;Communication;Communities;cost effective;Diabetes Mellitus;Diagnosis;Ecosystem;Environment;Etiology;Faculty;First Name;Fostering;Funding;Genetic;Genomics;Goals;Grant;Growth;Health;Illinois;improved;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;Knowledge;medical schools;member;Metabolic Diseases;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;next generation;novel strategies;novel therapeutics;Patients;Physical environment;Physiology;Prevention;Productivity;programs;Public Health;Research;Research Personnel;Resources;Risk;Scientist;Services;Strategic vision;Students;Technology;Training;Training and Education;training opportunity;Translating;Translational Research;Translations;Universities;Wisconsin

PROJECT_TITLE: Diabetes Research and Training Center


NIH_SPENDING_CATS: Diabetes

PI_NAMEs: MIRMIRA, RAGHAVENDRA G (contact)

PROJECT_TERMS: Advocacy;Area;authority;Awareness;base;Basic Science;bench to bedside;Biological Sciences;Biomedical Research;Chicago;Clinical;Clinical Research;Collaborations;Communication;Communities;Development;Diabetes Mellitus;education research;Ensure;Evaluation;Evolution;Fostering;Funding;Goals;Grant;improved;innovation;Institution;interdisciplinary collaboration;interest;Leadership;member;Mission;Occupational activity of managing finances;operation;Patients;Physical environment;Physicians;Play;programs;Public Health;Regulation;Research;Research Personnel;Scientist;Services;Strategic vision;Structure;Students;success;Training;training opportunity;Translations;Universities;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Cancer;Immunotherapy

PI_NAMEs: GALIC, ZORAN  (contact)

PROJECT_TERMS: Adjuvant;analytical tool;anti-cancer research;base;Biological Assay;Biological Markers;Blood Cells;BRAF gene;Cancer Center;Cancer Center Support Grant;cell analyzer;cell preparation;Cell Separation;cell separator;Cells;Charge;Clinic;Clinical;Collaborations;Communities;Comprehensive Cancer Center;Computer Workstations;Consultations;Control Groups;Core Facility;cost;Cytometry;Data Analyses;Dendritic Cell Vaccine;Development;Doctor of Philosophy;Education;Educational process of instructing;Educational workshop;Ensure;Equipment;Evolution;experience;Experimental Designs;Flow Cytometry;Flow Cytometry Shared Resource;Glioma;high end computer;Hour;Human Resources;Image;Image Cytometry;Immune checkpoint inhibitor;Immunofluorescence Immunologic;In Vitro;Individual;Industry;inhibitor;Institution;Instruction;instrument;instrumentation;Investigation;Investments;Journals;Knowledge;Laboratories;large datasets;Lasers;Leadership;Magnetism;Manufacturer;Measurement;medical schools;meetings;MEKs;Melanoma;member;mouse model;mutant;NCI Center for Cancer Research;Neoadjuvant Therapy;new technology;novel;operation;Patients;pembrolizumab;Phase I Clinical Trials;posters;preclinical study;Probability;programs;Protocols documentation;Publications;Randomized;randomized trial;Reagent;Research;Research Personnel;Research Project Grants;Resource Sharing;Running;Schedule;Secure;Services;Signal Pathway;Sorting;Specialist;Speed;Technology;technology development;tool;Training;Tumor-Infiltrating Lymphocytes;Update;web site;Work;Zoran

PROJECT_TITLE: Flow Cytometry Shared Resource (FCSR)


PI_NAMEs: LI, XINMIN  (contact)

PROJECT_TERMS: Acceleration;anti-cancer research;Applications Grants;Area;Award;base;Bioinformatics;Cancer Center;Cancer Center Support Grant;Cancer Research Project;Cells;Chromium;Clinical;Communities;community center;Comprehensive Cancer Center;cost effective;Data Analyses;Development;discount;Doctor of Philosophy;Education;Educational workshop;Ensure;experience;experimental study;Faculty;flexibility;Funding;Gene Chips;Genomics;Genomics Shared Resource;Goals;Health Sciences;improved;Individual;Institution;instrument;Interdisciplinary Study;Investments;Journals;Knowledge;Laboratories;Lead;Leadership;Malignant Neoplasms;Measures;medical schools;member;Movement;multidisciplinary;NCI Center for Cancer Research;new technology;next generation;next generation sequencing;novel;Peer Review;Policies;Price;Productivity;programs;Publications;quality assurance;Research;research and development;Research Personnel;Research Project Grants;Resource Sharing;satisfaction;Science;Scientist;Services;Structure;success;Surveys;System;Technology;Time;Training;training opportunity;Training Programs;translational pipeline;Variant;Work

PROJECT_TITLE: Genomics Shared Resource (GSR)


ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: Project Narrative The project seeks to demonstrate feasible in the conduct of an early detection study in individuals at high risk of developing bladder cancer and to evaluate a relevant rodent model, capable of identifying novel biomarkers, which can be applied in the clinic.

PI_NAMEs: FURUYA, HIDEKI ;ROSSER, CHARLES J (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Address;American;Animal Model;Biological Assay;Biological Markers;Bladder;Bladder Neoplasm;Blood;cancer biomarkers;cancer diagnosis;Cancer Diagnostics;Cancer Model;Cancer Patient;candidate marker;carcinogenesis;Carcinogens;Cessation of life;Clinic;Clinical;clinical application;clinical development;clinical diagnosis;clinically relevant;cohort;combat;Cytometry;Data;Death Rate;Diagnosis;diagnostic signature;Disease;Early Diagnosis;Early identification;Educational workshop;Epithelium;Evaluation;Exposure to;Future;Hematuria;high risk;high risk population;Human;IL8 gene;Image;Immunoassay;improved;Individual;innovation;Link;Location;longitudinal, prospective study;Malignant neoplasm of urinary bladder;Malignant Neoplasms;men;Messenger RNA;Methodology;Methods;MMP9 gene;Modality;Mus;Non-Invasive Detection;novel;novel marker;Outcome;overexpression;Patients;Phase;Pilot Projects;Plasminogen Activator Inhibitor 1;Predictive Value;prospective;Prospective Studies;protein biomarkers;Recording of previous events;Research;research clinical testing;Risk;Rodent Model;Role;Sampling;single-cell RNA sequencing;Smoker;Specificity;stromelysin 2;surveillance study;Survival Rate;Technology;Testing;Time;Tissues;tumor;Tumor Biology;tumor initiation;tumor microenvironment;tumorigenesis;urinary;Urine;Validation;VEGFA gene

PROJECT_TITLE: A Multiplex Protein Biomarker-Based Immunoassay for the Early Detection of Bladder Cancer and its Implications in Tumor Biology

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


PI_NAMEs: DAMOISEAUX, ROBERT  (contact)

PROJECT_TERMS: Acoustics;Acute Myelocytic Leukemia;Address;Antibodies;Antineoplastic Agents;assay development;Biological;Biological Assay;Biological Products;Blood - brain barrier anatomy;blood-brain barrier crossing;Cancer Center Support Grant;cDNA Library;Cell Line;Cells;Chemicals;cheminformatics;Clinic;Clinical assessments;clinical candidate;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Communities;Complementary DNA;Comprehensive Cancer Center;cost;Cost Savings;CRISPR screen;CRISPR/Cas technology;Data Analyses;Development;Doctor of Philosophy;Dose;drug candidate;drug development;drug discovery;Drug Kinetics;drug metabolism;Drug Targeting;Dysmyelopoietic Syndromes;Education;efflux pump;Ensure;experimental study;Extramural Activities;Faculty;Fee-for-Service Plans;follow-up;Foundations;functional genomics;Funding;Gene Expression;Generations;Genome;genome-wide;Genomic Library;Genomics;Goals;high throughput screening;Human;Human Genome;Immunooncology;Industrialization;Industry;Infrastructure;International;Investigation;Journals;Knock-in;Knock-out;Knowledge;Laboratories;lead optimization;Leadership;Learning;Legal patent;Libraries;Malignant neoplasm of brain;Malignant Neoplasms;Medicine;meetings;member;Microscopy;miniaturize;Modality;Modeling;Molecular;Molecular Target;multidrug resistant cancer;Mus;next generation;next generation sequencing;Organizational Models;Peer Review;Penetrance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenotype;Preparation;Productivity;Protein Inhibition;protein protein interaction;Publications;Reader;Reagent;Recording of previous events;Reporter;Research;Research Contracts;Research Personnel;Research Project Grants;Resource Sharing;Resources;response;RNA Splicing;Robotics;Sampling;Scientist;screening;screening services;sequencing platform;Service delivery model;Services;small hairpin RNA;Small Interfering RNA;small molecule;small molecule libraries;Specificity;Speed;Spliced Genes;Spliceosomes;Students;success;Suggestion;System;Technology;Testing;Therapeutic antibodies;Toxic effect;Training;Transfection;Veterans;Work

PROJECT_TITLE: Molecular Screening Shared Resource (MSSR)


NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human

PI_NAMEs: BRADY, MATTHEW J (contact)

PROJECT_TERMS: Address;Adipocytes;Beta Cell;Biological;Biomedical Research;Calcium Signaling;Cell Line;Cells;Cellular biology;Chicago;Circadian Rhythms;Collaborations;Data Analyses;Development;Diabetes Mellitus;diabetic;diabetogenic;Disease;Education;Endocrine;Ensure;Environment;experimental study;extracellular vesicles;Fatty Acids;Genetic;Genomics;Glucose;glucose uptake;Goals;Health;Hepatocyte;Human;Illinois;Immune;immune imaging;improved;in vivo;Individual;induced pluripotent stem cell;Insulin deficiency;Insulin Resistance;insulin secretion;insulin signaling;insulinoma;investigator training;islet;Islet Cell;Islets of Langerhans;kidney cell;lipid biosynthesis;Macrophage;Measurement;member;Metabolic;Methods;migration;Mission;Modeling;Mus;nano-string;neutrophil;non-diabetic;oxidation;Patients;Physiological;Physiology;Polyribosomes;Procedures;Research;Research Design;Research Personnel;Rodent;Role;Services;Students;synergism;System;T-Lymphocyte;Techniques;Technology;Testing;Time;Tissues;Training;Training and Education;Universities;uptake;Zebrafish

PROJECT_TITLE: Cell Biology Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_DEPT: PHARMACOLOGY

PHR: Public Heath Relevance/Narrative MYCN is a major driver of childhood cancers including neuroblastoma. However, currently no drugs have been approved against the MYCN oncoprotein. Successful completion of this project will provide quantitative understanding and new insights into MYCN oncogenic signaling and how MYCN regulates gene transcription and transforms cells, and may lead to new approaches to therapy.

PI_NAMEs: SHU, XIAOKUN  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, ERIC MICHAEL

PROJECT_TERMS: Address;Affect;aurora kinase A;Automobile Driving;Behavior;Binding;Biochemical;Biological;Biological Process;Biophysics;c-myc Genes;Cell Nucleus;cell transformation;Cells;Chemicals;Color;Development;Disease;DNA Binding Domain;DNA Sequence;Engineering;Fibroblasts;fluorescence imaging;Gene Expression;Genetic;Genetic Transcription;Health;high risk;Human;Image;insight;Label;Link;Liquid substance;Malignant Childhood Neoplasm;Malignant Neoplasms;Mediator;Membrane;Modeling;Molecular;MYCN gene;Neuroblastoma;neuroblastoma cell;novel strategies;Oncogenic;Oncoproteins;Pharmaceutical Preparations;Phase;Physical condensation;Play;Proteins;public health relevance;quantitative imaging;Rat-1;Reporting;RNA Polymerase II;Role;Signal Transduction;small molecule inhibitor;Structure;System;Technology;Tissues;tool;Transcription Coactivator;transcription factor;transcriptome sequencing;TRRAP gene;tumor;tumorigenesis;Up-Regulation;Work

PROJECT_TITLE: Imaging and manipulating oncoprotein phase separation and compartmentalization


PI_NAMEs: CHATZIIOANNOU, ARION XENOFON (contact)

PROJECT_TERMS: Address;Advanced Development;animal imaging;Applied Research;authority;Autoradiography;Biochemistry;Biological Assay;Biological Markers;Biological Sciences;Biology;Bioluminescence;California;Cancer Biology;Cancer Center Support Grant;Carcinoma in Situ;Cells;Chemicals;Chemistry;Clinical Trials;Collaborations;Combined Modality Therapy;Communities;Comprehensive Cancer Center;contrast enhanced;court;Cyclotrons;Data Analyses;Deoxycytidine Kinase;design;Detection;Doctor of Philosophy;Educational process of instructing;Educational workshop;Engineering;Ensure;experience;Experimental Designs;experimental study;Faculty;Fluorescence;Fluorine;Funding;Glioblastoma;Glucose;Glycolysis;Grant;health science research;Hour;Housing;Human Resources;Image;Image Analysis;imaging approach;Imaging Device;imaging modality;imaging probe;imaging study;Imaging Techniques;Imaging technology;Immunotherapy;in vivo;in vivo evaluation;in vivo imaging;Inflammatory Response;innovation;Institution;instrument;instrumentation;invention;Iodination reaction;Journals;kinase inhibitor;Label;Laboratories;Laboratory Animal Medicine;Location;Magnetic Resonance Imaging;Malignant Neoplasms;mathematical sciences;Measurement;medical schools;member;microCT;microPET;minimally invasive;Modality;Molecular;Molecular Biology;molecular imaging;Mus;nanosystems;NCI Center for Cancer Research;novel;novel imaging technology;novel therapeutics;Operative Surgical Procedures;optical imaging;Optics;Peer Review;peer support;Peptides;Performance;PET/CT scan;Pharmacodynamics;pharmacokinetics and pharmacodynamics;physical science;Positron-Emission Tomography;preclinical imaging;Prediction of Response to Therapy;Procedures;Production;programs;Proteins;Protocols documentation;Publications;radiation resistance;Radiochemistry;Radiolabeled;Rattus;Recording of previous events;Research;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Resources;Safety;Schools;Science;screening;Services;Small Animal Imaging Shared Resource;small molecule;Source;Stem Cell Research;targeted treatment;Technology;Testing;therapy development;Tracer;Training;tumor metabolism;tumor progression;United States National Institutes of Health;Vertebrates;X-Ray Computed Tomography

PROJECT_TITLE: Small Animal Imaging Shared Resource (SAISR)


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_CITY: Newark

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: Project Narrative The leading cause of death in patients who have epilepsy, but do not have good control over their seizures is sudden unexpected death in epilepsy (SUDEP). It is currently unclear why some seizures result in death when so many others do not. Identifying how two transmitter systems, serotonin and adenosine, interact during seizures may provide insights into why seizure-induced death happens and what can be done to prevent it.

PI_NAMEs: PURNELL, BENTON SCOTT (contact)

PROGRAM_OFFICER_NAME: KIM, JENNY LILY

PROJECT_TERMS: Adenosine;Affect;Arousal;Brain;Brain Stem;brain tissue;Breathing;Carbon Dioxide;career;Cause of Death;Cell Nucleus;Cessation of life;Disease;Epilepsy;epileptiform;Etiology;expectation;experimental study;extracellular;Functional disorder;Goals;insight;Knowledge;Life;Link;Mentorship;Mus;neural;Neural Inhibition;Neurologic;Neurons;neurotransmission;Patients;Persons;pharmacologic;premature;prevent;Prevention;raphe nuclei;Regulation;Respiration Disorders;respiratory;Respiratory Failure;Respiratory physiology;Role;Science;Seizures;Serotonergic System;Serotonin;Signal Transduction;Stroke;sudden unexpected death in epilepsy;System;Testing;Therapeutic;Tissues;Training;Travel;Writing

PROJECT_TITLE: Role of adenosinergic inhibition of serotonin neurons in seizure induced respiratory arrest

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


PI_NAMEs: FRENCH, SAMUEL  (contact)

PROJECT_TERMS: Accreditation;Adopted;Adoptive Transfer;Algorithmic Analysis;American;Animals;anti-cancer research;Antibodies;Basic Science;biobank;Biopsy Specimen;Blood;Board Certification;California;Cancer Center;Cancer Center Support Grant;Cell Separation;Cells;Clinical;clinical diagnostics;Clinical Research;Clinical Trials;Collaborations;college;Color;Complex;Comprehensive Cancer Center;Computerized Medical Record;Consent;Consultations;Core Biopsy;cost;County;Creativeness;CTAG1 gene;CTLA4 blockade;Custom;Data;dendritic cell vaccination;Development;Diagnostic;digital imaging;digital pathology;Disease;Doctor of Philosophy;Dryness;electronic consent;Electronics;Evaluation;Event;Fees;Formalin;Freezing;Fresh Tissue;Future;Glucose Transporter;Goals;Histology;Human;human tissue;Image Analysis;Immunofluorescence Immunologic;Immunohistochemistry;Immunotherapy;improved;In Situ Hybridization;innovation;innovative technologies;Institutional Review Boards;International Classification of Disease Codes;Interventional radiology;ipilimumab;Journals;Laboratories;laser capture microdissection;Los Angeles;Lung Adenocarcinoma;Malignant Neoplasms;Medical Records;medical schools;member;Microscopy;NCI Center for Cancer Research;novel;Paraffin Embedding;Pathologist;Pathology;Patients;Peptides;Peripheral Blood Mononuclear Cell;Physiologic pulse;Population;Population Characteristics;Process;programs;Publications;Research;Research Design;Research Personnel;Resistance;Resource Sharing;Retrieval;RNA;Route;sample archive;Sampling;Services;Slide;Sodium;Specimen;Stains;System;T-Cell Receptor;Testing;therapeutic target;Tissue Embedding;Tissue Procurements;Tissue Sample;Tissues;translational goal;Translational Research;tumor;tumor progression;Universities;virtual;Visit;ward;Work

PROJECT_TITLE: Translational Pathology Core Laboratory Shared Resource (TPCL)


PI_NAMEs: CZERNIN, JOHANNES  (contact)

PROJECT_TERMS: ALCAM gene;analytical method;analytical tool;Animal Disease Models;antibody engineering;Biological Assay;Biological Markers;Biological Process;Biology;Cancer Biology;Cancer Burden;Cancer Center;Cancer Center Support Grant;cancer immunotherapy;Cancer Patient;cancer therapy;candidate identification;Catchment Area;CD8B1 gene;Cell surface;Chemistry;Clinic;Clinical;clinical application;clinical implementation;Clinical Trials;Clofarabine;Collaborations;Community Health Education;Community Outreach;Complement;County;Data;design;Development;Diagnosis;Diagnostic;Direct Costs;Discipline of Nuclear Medicine;Doctor of Philosophy;Dose;Drug Delivery Systems;drug development;Engineering;Evolution;Faculty;Funding;Genes;Goals;health disparity;Image;image reconstruction;image translation;imaging approach;imaging modality;Imaging technology;Immune checkpoint inhibitor;immune imaging;Immune response;Immune system;immunoregulation;Immunotherapy;improved;in vivo;Individual;Inflammation;innovation;Institution;instrumentation;invention;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Journals;Laboratories;Lead;Legal patent;Los Angeles;Magnetic Resonance Imaging;Malignant Neoplasms;Mass Spectrum Analysis;Measurement;member;Metabolism;Methodology;Methods;molecular imaging;Molecular Probes;Molecular Target;Monitor;MS4A1 gene;nanoengineering;nanomaterials;nanoparticle;nanoparticle delivery;Nanotechnology;non-invasive imaging;novel;novel strategies;Nucleosides;optical spectra;Organism;particle therapy;Patient Care;Patient-Focused Outcomes;Patients;Peer Review;Penetration;Peptide Receptor;Performance;Pharmaceutical Preparations;Physics;Play;Positron-Emission Tomography;pre-clinical;programs;Publications;Radiation Oncology;Radioactive;Radiochemistry;Radioisotopes;radioligand;Radiology Specialty;Research;Research Personnel;Resistance;resistance mechanism;Resource Sharing;response;Schools;Science;single photon emission computed tomography;small molecule;System;systemic toxicity;T cell therapy;targeted treatment;theranostics;Therapeutic;Toxic effect;trafficking;Translating;translational approach;translational diagnostics;translational potential;Translations;treatment response;tumor;Tumor Biology;tumor microenvironment;tumor progression;Urology;Work

PROJECT_TITLE: Cancer Molecular Imaging, Nanotechnology and Theranostics


PI_NAMEs: BELL, GRAEME I (contact)

PROJECT_TERMS: Acceleration;Address;analytical tool;Animal Model;Awareness;Bacterial Artificial Chromosomes;biobank;Biological;Biomedical Research;Cell Line;Cell model;Cell Physiology;Cells;Cellular biology;Circulation;Clinical;Cloning;Cloud Computing;Collection;computational platform;Consultations;cost;cost effective;Cost Savings;Country;Data;design;Development;Diabetes Mellitus;diabetes mellitus genetics;Diagnosis;digital;Disease;DNA;DNA Sequence;epigenome;epitranscriptome;Evolution;exome;Family;Funding;gene discovery;Gene Expression;Gene Expression Profiling;Gene Mutation;Generations;Genes;Genetic;genetic analysis;Genetic Counseling;Genetic Medicine;genetic resource;Genetic study;genetic testing;Genetic Variation;genome editing;genome sequencing;genomic variation;Genomics;Genotype;Goals;Health Insurance;HNF4A gene;Human;Hyperglycemia;In Vitro;in vivo;Individual;Infrastructure;Insurance Coverage;International;Investments;Length;Link;Longitudinal Studies;maturity onset diabetes of the young;Measures;Methods;Mutation;mutation screening;Neonatal;neonatal diabetes mellitus;Nucleic Acids;Obesity;Patients;Peripheral Blood Mononuclear Cell;Phenotype;Physicians;Physiological;Plasma;precision genetics;Prognosis;programs;Registries;Research;Research Personnel;Resources;Role;Saliva;Sampling;Serum;Services;success;Syndrome;Technology;Test Result;Testing;Tissues;tool;Training;United States;Untranslated RNA;Variant;web site;whole genome;Work

PROJECT_TITLE: Genetics and Genomics Core


NIH_SPENDING_CATS: Cancer;Hematology;Immunotherapy;Lung;Lung Cancer;Prostate Cancer;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation;Urologic Diseases

PI_NAMEs: CROOKS, GAY M (contact)

PROJECT_TERMS: Achievement;Animal Model;Award;Behavior;Biological;Biological Models;Biological Process;Biology;Blood Vessels;Bone Marrow;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer initiation;Cancer Patient;cancer therapy;Carcinoma;Catchment Area;Cell Proliferation;Cells;Chemicals;chemotherapy;Clinical;Collaborations;collaborative environment;Colon Carcinoma;County;Development;Differentiation and Growth;engineered T cells;Environment;Epithelial Cells;epithelial stem cell;Epithelium;Extracellular Matrix;Faculty;Fibroblasts;Focus Groups;Fostering;Funding;Gays;Goals;Grant;Growth;Hair;Hematopoiesis;Hematopoietic;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Homeostasis;Human;human pluripotent stem cell;human tissue;Immune;Immunotherapy;Inflammatory;Informal Social Control;inhibitor;insight;Institution;interest;Invaded;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Journals;Legal patent;Lesion;leukemia/lymphoma;Licensing;Link;Los Angeles;Lung;lung carcinogenesis;Lymphoid Cell;Lymphopoiesis;Malignant - descriptor;Malignant lymphoid neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;member;Metabolism;Mitochondria;Modeling;Molecular;Natural regeneration;neoplastic cell;new therapeutic target;novel;Oncogenic;Organoids;Pathway interactions;Peer Review;peripheral blood;premalignant;Process;Productivity;programs;Prostate;Publications;pyruvate carrier;recruit;Recurrence;Regulation;repaired;Reproducibility;Research;Research Personnel;Resource Sharing;Role;Schools;Science;self-renewal;Signaling Molecule;Small Cell Carcinoma;small molecule;Source;stem cell biology;Stem Cell Research;stem cells;T-Lymphocyte;technology platform;therapeutic biomarker;Thymus Gland;tissue stem cells;Tissues;tool;Translating;translational scientist;Transplantation;tumor;tumor microenvironment;Umbilical Cord Blood;United States National Institutes of Health;Work

PROJECT_TITLE: Cancer and Stem Cell Biology


NIH_SPENDING_CATS: Antimicrobial Resistance;Building Research Capacity at Institutions with Limited NIH Funding;Emerging Infectious Diseases;Infectious Diseases

ORG_DEPT: CHEMISTRY

ORG_NAME: CITY COLLEGE OF NEW YORK

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it aims to overcome a major mechanism of antibiotic resistance by Gram-negative bacteria -the exclusion of antibiotics by the lipopolysaccharide (LPS) outer membrane. Our proposed studies seek to understand how a bacteriophage fuses its bacterial phospholipid membrane with the LPS of its Gram-negative host. This research will have the potential to overcome the antibiotic exclusionary properties of the LPS by generating phospholipid derived vesicles capable of targeting specific strains of Gram-negative bacteria for delivery of antibiotics.

PI_NAMEs: KHAYAT, REZA  (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Amino Acid Sequence;Amino Acid Substitution;Antibiotic Resistance;antibiotic resistant infections;Antibiotic-resistant organism;Antibiotics;Architecture;Area;bacterial resistance;Bacteriophages;Binding;Biochemical;Bioinformatics;biophysical analysis;Biophysics;Cells;Centers for Disease Control and Prevention (U.S.);Cessation of life;Communication;Complex;Cryo-electron tomography;Cryoelectron Microscopy;Cystovirus;Data;egg;Escherichia coli;Eukaryota;Eukaryotic Cell;Exclusion;Family;Family member;Fluorescence Spectroscopy;Glycoproteins;Goals;Gram-Negative Bacteria;Health;Herpesviridae;HIV;Horizontal Gene Transfer;Human;Infection;Invaded;Knowledge;Lateral;Learning;Life;Light;Lipid A;Lipopolysaccharides;member;Membrane;Membrane Fusion;Modernization;Molecular Conformation;Molecular Machines;Multiprotein Complexes;Muscle Cells;Myoblasts;nanotherapeutic;Nature;Nerve;O Antigens;Organelles;pathogen;pathogenic bacteria;pathogenic fungus;Pathogenicity;Peptides;Permeability;Phospholipids;Process;Property;protein complex;Proteins;Pseudomonas aeruginosa;Pseudomonas syringae;Public Health;recruit;Reporting;Research;Salmonella typhimurium;scaffold;Site;sperm cell;structural determinants;Structure;Synaptic Vesicles;System;Technology;Testing;Therapeutic Uses;urgent and serious threat;Vacuole;Vesicle;Viral;Virus Diseases;West Nile virus;X-Ray Crystallography

PROJECT_TITLE: Mechanism of membrane fusion involving the Gram-negative bacteria outer membrane


PI_NAMEs: CAREY, MICHAEL F (contact)

PROJECT_TERMS: Achievement;Address;Animal Model;Animals;Bioinformatics;Biological Models;Biological Process;Biology;Breast;Cancer Biology;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer genome;cancer initiation;cancer type;Catchment Area;Cell Cycle;Cell Differentiation process;cell free DNA;Cell model;Cells;Chromatin;Clinical;Collaborations;Colorectal;Computer Analysis;County;Coupled;Data;Dependence;Development;Diagnostic;Direct Costs;Disease;DNA Sequence Alteration;DNA sequencing;Ensure;Environment;epigenome;epigenomics;expectation;Faculty;Fostering;Funding;Gene Expression Regulation;Genes;Genetic Transcription;Genome;genome-wide;Genomics;Goals;health disparity;High-Throughput Nucleotide Sequencing;Histone Deacetylase Inhibitor;Human Resources;Immune response;Inflammation;Informatics;innovation;insight;Institution;interest;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Journals;Knowledge;Knowledge acquisition;large datasets;Link;lipid metabolism;Liver;Los Angeles;Lung;Malignant Neoplasms;member;Metabolic;metaplastic cell transformation;Methodology;Modeling;Molecular;new technology;next generation;novel;novel diagnostics;novel strategies;Organism;Paper;Pathologic Processes;Peer Review;permissiveness;Physiological Processes;Plants;Postdoctoral Fellow;pre-clinical;preclinical study;Productivity;prognostic;programs;Prostate;Proteomics;Publications;recruit;Regulation;Research;Research Personnel;RNA;Schools;Science;stem cell self renewal;Structure;Students;Technology;Therapeutic;tool;Training;Training Programs;Translating;translational applications;translational physician;translational scientist;Translations;treatment strategy;tumor;tumor progression;tumorigenesis;Viral;Viral Oncogene;Yeasts

PROJECT_TITLE: Epigenomics, RNA and Gene Regulation


NIH_SPENDING_CATS: Cancer;Clinical Research;Immunotherapy;Precision Medicine;Skin Cancer

ORG_DEPT: PATHOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Blockade of the inhibitory checkpoint programmed-death 1 (PD-1) can be an effective immunotherapy for cancers, but many patients do not respond, and the mechanisms that drive resistance are not well understood. We will investigate how the intrinsic properties of tumor-specific T cells and the overarching influence of T cell receptor affinity determine T cell responsiveness to PD-1 blockade. This work has the potential to identify new strategies for overcoming therapeutic resistance to PD-1 blockade.

PI_NAMEs: KROGSGAARD, MICHELLE  (contact);ZHU, CHENG

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Affect;Affinity;antigen-specific T cells;Antigens;Antitumor Response;Automobile Driving;Binding;Biological Assay;Biological Models;cancer immunotherapy;cancer therapy;CD8B1 gene;Cell Adhesion;Cells;Characteristics;Chromatography;Combined Modality Therapy;cross reactivity;Development;effective therapy;Event;experimental study;Gene Expression;Gene Expression Profile;Genetic Transcription;Genomics;Goals;humanized mouse;immune checkpoint blockade;improved;In Vitro;in vivo;Intrinsic factor;Knowledge;Link;Major Histocompatibility Complex;Melanoma;Melanoma patient;Molecular Profiling;mouse model;new technology;novel;Patient Isolation;patient response;Patient Selection;Patients;Pattern;Peptides;Phosphorylation;Population;potential biomarker;predictive marker;Predisposition;programmed cell death ligand 1;programmed cell death protein 1;Property;Proteomics;receptor;receptor binding;Receptor Signaling;Resistance;resistance mechanism;response;Role;Sampling;Selection for Treatments;Signal Pathway;Signal Transduction;Stains;T cell response;T cell therapy;T-Cell Activation;T-Cell Receptor;T-cell receptor repertoire;T-Lymphocyte;Testing;therapy resistant;transcriptomics;treatment optimization;treatment response;tumor;Tumor Antigens;Tumor-Infiltrating Lymphocytes;unnecessary treatment;Work

PROJECT_TITLE: T-cell intrinsic mechanisms of resistance to PD-1 checkpoint blockade

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Sleep Research

ORG_CITY: BOSTON

ORG_NAME: BOSTON VA RESEARCH INSTITUTE, INC.

ORG_STATE: MA

PHR: Sleep loss, acute or chronic, is experienced by many and is a problem in our modern society. Sleep deprivation leads to excessive daytime sleepiness, emotional difficulties, poor job performance, an increased risk for a number of physical and mental health ailments and overall lower perception of the quality of life. Therefore, as proposed in this application, understanding how the brain responds to sleep loss and localizing the relevant target areas and neuronal subpopulations will inform therapeutic interventions.

PI_NAMEs: BASHEER, RADHIKA  (contact)

PROGRAM_OFFICER_NAME: HE, JANET

PROJECT_TERMS: Accidents;Acetylcholine;Acute;Address;Adenosine;Area;Arousal;Attenuated;basal forebrain;basal forebrain cholinergic neurons;Brain;Brain Stem;cholinergic;Cholinergic Antagonists;cholinergic neuron;Cholinergic Receptors;Chronic;combat;Data;Drosophila genus;Drowsiness;Electroencephalography;Emotional;Excessive Daytime Sleepiness;Excitatory Amino Acid Antagonists;experience;experimental study;extracellular;Felis catus;gamma-Aminobutyric Acid;Glutamate Transporter;Glutamates;Goals;Homeostasis;Impaired cognition;Impulsivity;in vivo;Infusion procedures;Intervention;Investigation;Lesion;Life Style;Mammals;Measures;Mediating;Mental Health;Microdialysis;Modernization;Mus;neural;neural correlate;neurochemistry;Neurons;neuropsychiatric disorder;Neurotransmitters;Nitric Oxide;non rapid eye movement;novel;Optics;optogenetics;Outcome Measure;Parvalbumins;Perception;Performance at work;pharmacologic;physical conditioning;Play;Population;prevent;Quality of life;Rattus;receptor;Reporting;response;Risk;Role;Sleep;Sleep Deprivation;Sleep disturbances;Societies;System;Testing;Therapeutic Intervention;vesicular glutamate transporter 2;Vocation;Wakefulness;Work

PROJECT_TITLE: Neural Correlates of Sleep Homeostasis

STUDY_SECTION: BNRS

STUDY_SECTION_NAME: Behavioral Neuroendocrinology, Neuroimmunology, Rhythms, and Sleep Study Section [BNRS]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Rare Diseases;Skin Cancer;Urologic Diseases;Women's Health Research

PI_NAMEs: FINN, RICHARD S (contact)

PROJECT_TERMS: Acceleration;Adoption;Adult;Affect;Area;Basic Science;BRAF gene;cancer cell;Cancer Center Support Grant;cancer clinical trial;Cancer Patient;Catchment Area;Cell Cycle;Censuses;Clinical;clinical application;clinical development;Clinical Investigator;Clinical Research;Clinical Sciences;clinical translation;Clinical Trials Network;Collaborations;Colon Carcinoma;commercialization;Communities;Community Health Education;Comprehensive Cancer Center;County;Cyclin-Dependent Kinase Inhibitor;Data;Development;Direct Costs;Disparity;Disparity population;Educational Activities;enzalutamide;ethnic diversity;flexibility;Fostering;Foundations;Funding;Future;Genes;Goals;Growth;health care availability;health care disparity;High Prevalence;Histology;hormone receptor-positive;improved;improved outcome;Incentives;Incidence;inhibitor;Institution;Intervention;Journals;Laboratory Research;Laboratory Scientists;Lead;Link;Location;Los Angeles;Malignant Breast Neoplasm;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Medical;Medicine;MEKs;Melanoma;Melanoma patient;member;Metabolic;Metabolic Pathway;Metabolism;Mining;Monoclonal Antibodies;mortality;mutant;Mutation;NCI Center for Cancer Research;New Agents;novel strategies;novel therapeutics;Nursing Faculty;Pathogenesis;Pathway interactions;Peer Review;Pharmaceutical Preparations;pre-clinical;Prevalence;Process;Productivity;programs;Prostate Cancer therapy;Publications;Reagent;Research;research faculty;Research Personnel;Resistance;response;Role;Schools;Scientist;Signal Pathway;Signal Transduction;Signal Transduction Inhibitor;Signal Transduction Pathway;Skin Cancer;small molecule inhibitor;socioeconomics;success;targeted agent;targeted cancer therapy;Therapeutic;therapeutic candidate;Therapeutic Research;Training and Education;Translating;translational oncology;translational physician;translational pipeline;Translational Research;translational research program;Translations;tumor;Work

PROJECT_TITLE: Signal Transduction and Therapeutics


PI_NAMEs: HARA, MANAMI  (contact)

PROJECT_TERMS: Adenine Nucleotides;Animal Model;Appetitive Behavior;Area;assay development;Atrophic;Back;behavioral study;Beta Cell;Bioenergetics;Biopsy;Body Composition;C-Peptide;Calorimetry;Cell Physiology;Chicago;Circadian Dysregulation;Circadian Rhythms;Clinical Research;Collaborations;Core Facility;Desire for food;Development;Diabetes Mellitus;diabetic;Digestive System Disorders;Disease;Evolution;experience;Family;Fatty acid glycerol esters;feeding;Functional disorder;Generations;Gestational Diabetes;Glucose;glycemic control;Goals;Human;human model;human subject;human tissue;Image Analysis;in vivo;Institution;Insulin Resistance;insulin secretion;investigator training;islet;Knowledge;Label;Measurement;Measures;Metabolic;Metabolic Diseases;metabolic phenotype;metabolic rate;Microbe;microbiome;Mission;Modeling;mouse model;Mus;non-diabetic;Obesity;Pancreas;Physiological;Physiology;Research;Research Personnel;Resources;Role;Services;Sleep Disorders;Sleep disturbances;Sterols;Structure;Structure of beta Cell of islet;Techniques;Technology;Tissues;tool;Training;translational pipeline;transplant model;Universities

PROJECT_TITLE: Physiology Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Orphan Drug;Rare Diseases

PI_NAMEs: RIBAS, ANTONI  (contact)

PROJECT_TERMS: Achievement;Adoptive Cell Transfers;AIDS related cancer;American Association of Cancer Research;anti-cancer research;anti-tumor immune response;Antibodies;antibody conjugate;antigen-specific T cells;Area;Asian population;Award;B-Cell Lymphomas;Biomedical Engineering;Cancer Burden;cancer cell;Cancer Center Support Grant;cancer immunotherapy;cancer therapy;career;Catchment Area;CD19 gene;Cell Therapy;Cells;Cellular biology;cellular imaging;checkpoint receptors;chimeric antigen receptor;chimeric antigen receptor T cells;Chimeric Proteins;Clinical;Clinical Research;clinical translation;Clinical Trials;cohesion;Collaborations;collaborative environment;Colorectal;combinatorial;community engagement;Community Outreach;Comprehensive Cancer Center;County;Creativeness;cytokine;Development;Direct Costs;Doctor of Philosophy;Education;engineered T cells;Engineering;Environment;ethnic minority population;Flow Cytometry Shared Resource;Fostering;frontier;Funding;Funding Mechanisms;Gene Modified;Genes;Genetic Engineering;Goals;Good Manufacturing Process;graduate student;Hematologic Neoplasms;Human;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune system;Immunologic Monitoring;Immunology;Immunosuppression;Immunotherapy;immunotherapy clinical trials;immunotherapy trials;improved;in vivo;Incidence;Inflammation;Infrastructure;Institution;Intervention;Journals;kinase inhibitor;Laboratory Finding;Latino Population;Lead;Los Angeles;Lung;Lymphoma;Malignant neoplasm of brain;Malignant neoplasm of liver;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;manufacture;Medicine;meetings;Melanoma;member;Mentors;Mission;Monoclonal Antibodies;multidimensional data;Natural Killer Cells;non-invasive imaging;novel;Patients;Peer Review;Pharmaceutical Preparations;Postdoctoral Fellow;Pre-Clinical Model;preclinical study;programs;Prostate;Proteins;Publications;Publishing;recruit;Regulation;Renal Carcinoma;Research;Research Personnel;Resistance;Resource Sharing;Resources;response;Route;Schools;Science;Series;Site;Small Animal Imaging Shared Resource;small molecule;supportive environment;synthetic biology;T cell response;T-Cell Receptor;T-Lymphocyte;targeted agent;Testing;Therapeutic;Therapeutic antibodies;therapeutic protein;Training;Training and Education;Training Programs;Translating;translational physician;translational scientist;Translations;tumor;Tumor Antigens;Tumor Cell Biology;Tumor Escape;tumor immunology;tumor microenvironment;United States National Institutes of Health;whole body imaging;Work

PROJECT_TITLE: Tumor Immunology


NIH_SPENDING_CATS: Breast Cancer;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Genetics;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: TEXAS SOUTHERN UNIVERSITY

ORG_STATE: TX

PHR: NARRATIVE The MYBL1 gene has been shown to be involved in many of the biological events that drive cancers. The current project is designed to study and compare the MYBL1 gene in non-tumor compared to tumor breast cancer cells and patient samples to better understand the cancers.

PI_NAMEs: PLAYER, AUDREY  (contact)

PROGRAM_OFFICER_NAME: CUPIT, PAULINE

PROJECT_TERMS: Affect;Agar;aggressive breast cancer;Biological;Biological Assay;Biological Response Modifier Therapy;Breast;Breast Cancer Cell;Breast Cancer cell line;Burkitt Lymphoma;Cancer Patient;cancer subtypes;cancer type;Candidate Disease Gene;Cell Cycle;Cell Cycle Progression;Cell Line;Cells;Characteristics;Colon;comparative;Contact Inhibition;Data;Data Analyses;Dependence;design;differential expression;disease prognosis;Down-Regulation;Event;experimental study;Gene Expression Profile;Gene Family;Genes;genetic signature;Immunohistochemistry;In Vitro;interest;knock-down;Knowledge;Laboratories;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;MCF10A cells;Microarray Analysis;MYBL1 gene;MYBL2 gene;neoplastic cell;novel;Oncogenes;overexpression;Pathway Analysis;Patients;Pattern;Play;Preparation;Principal Investigator;Procedures;Process;Proliferating;Property;Proto-Oncogenes;Publishing;receptor;Regulation;Research Personnel;Role;Sampling;screening;Signal Transduction;Signaling Protein;small hairpin RNA;Statistical Data Interpretation;Testing;therapeutic target;Tissue Microarray;Tissues;Transcription Coactivator;transcription factor;transcriptome;triple negative cancer;triple-negative invasive breast carcinoma;tumor progression;tumorigenic;Uterine Fibroids;Validation

PROJECT_TITLE: Comparative analyses of MYBL1 knockdown in non-tumor and triple negative breast cancer cells


NIH_SPENDING_CATS: Rare Diseases

ORG_CITY: SYRACUSE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

PHR: Project Narrative The proton-pumping vacuolar ATPase (V-ATPase; V1Vo-ATPase) is a multisubunit enzyme complex that is responsible for vital cellular functions in all eukaryotic organisms and which is linked to several devastating human diseases such as renal tubular acidosis, osteopetrosis, diabetes, neurodegeneration, cancer, and microbial and viral infections. This proposal requests funds for obtaining high-resolution structural information for active holo V-ATPase and its autoinhibited proton channel subcomplex in lipid nanodiscs to study inhibitor binding and for elucidating V-ATPase's unique mode of regulation, for elucidating biochemical properties of specific isoform containing human V-ATPase, and to develop single-domain antibodies directed against yeast and human V-ATPase subunit isoforms as a novel tool for studying V-ATPase's structure and regulatory mechanisms. The long-term goal of the project is to gain a molecular understanding of the enzyme's role in human disease, and to identify novel ways to modulate the activity of disease causing V-ATPase in a subunit isoform and tissue specific manner.

PI_NAMEs: WILKENS, STEPHAN  (contact)

PROGRAM_OFFICER_NAME: MACARTHUR, LINDA

PROJECT_TERMS: Acid-Base Equilibrium;Acids;Address;Albers-Schonberg disease;ATP phosphohydrolase;Binding;Biochemical;Biochemistry;Biological Models;Biophysics;Bone remodeling;Cell Physiology;Cell secretion;Cells;Cellular biology;Complex;Diabetes Mellitus;Disease;Dissociation;Embryo;Endocytosis;Environment;Enzymes;Eukaryotic Cell;Extracellular Space;fighting;Funding;Goals;Human;human disease;human tissue;Hyperactivity;in vitro Model;Infection;Influenza;inhibitor;interest;Knowledge;Laboratories;Link;Lipids;Male Infertility;Malignant Neoplasms;Membrane;microbial;Molecular;Motor;mRNA Differential Displays;Multienzyme Complexes;mutant;nanobodies;nanodisk;Nerve Degeneration;neurotransmitter release;novel;Organelles;Organism;Physiology;Process;programs;Property;Protein Isoforms;protein transport;Proton Pump;Protons;Regulation;Renal tubular acidosis;Request for Proposals;Research;Resolution;Role;Sperm Maturation;structural biology;Structure;System;targeted treatment;tissue culture;Tissues;tool;Up-Regulation;vacuolar H+-ATPase;Virus;Virus Diseases;Yeasts

PROJECT_TITLE: Structure and Regulatory Mechanisms of the Vacuolar ATPase

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(55)R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

PI_NAMEs: GANZ, PATRICIA A. (contact)

PROJECT_TERMS: Address;adverse outcome;Area;base;Behavioral;Biological;Breast Cancer survivor;Cancer Burden;cancer care;Cancer Center Support Grant;Cancer Control;Cancer Control Research;Cancer Detection;cancer diagnosis;cancer health disparity;Cancer Patient;cancer prevention;cancer risk;Cancer Survivor;Cancer Survivorship;care delivery;Catchment Area;Child;Clinical;Cognitive Therapy;Collaborations;college;Complex;Comprehensive Cancer Center;computed tomography screening;cost effectiveness;County;design;Diagnosis;Direct Costs;Disease;Dissemination and Implementation;Doctor of Philosophy;Dose;economic indicator;end of life;Environment;Epidemiologic Methods;Epidemiology;epidemiology study;Epigenetic Process;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Origin;Faculty;Funding;Gender;genetic risk factor;Genomic approach;Genomics;Health;health disparity;Health Policy;high risk;Human Papilloma Virus Vaccination;Immigrant;implementation research;implementation science;improved;Incidence;innovation;inter-institutional;Interdisciplinary Study;Intervention;Intervention Studies;Intervention Trial;Journals;Latina Population;Letters;Life Style;Long-Term Survivors;Los Angeles;Low income;Low Income Population;lung cancer screening;Machine Learning;Malignant Childhood Neoplasm;Malignant neoplasm of lung;Malignant Neoplasms;Medical Oncologist;medical schools;member;Methodology;Methods;minority children;Molecular Epidemiology;Morbidity - disease rate;mortality;Observational Study;Outcome;Outcomes Research;Patients;Peer Review;Population;Populations at Risk;Pregnancy;Primary Prevention;programs;protective factors;psychologic;Psychologist;psychosocial;Public Health Schools;Publications;Quality of Care;racial disparity;racial minority;Reproducibility;Research;Research Personnel;Resource Sharing;Risk Factors;Risk Reduction;safety net;Science;screening;Screening for cancer;screening guidelines;Sleeplessness;social;socioeconomic disparity;socioeconomics;standard of care;Survivors;Symptoms;synergism;Tai Ji;Target Populations;Testing;underserved community;uptake;vaccine acceptance;Vulnerable Populations;Work

PROJECT_TITLE: Cancer Control and Survivorship


NIH_SPENDING_CATS: Biotechnology;Natural Products

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE Chemical Synthesis of Complex Natural Products for Translational Science The goals of the continuing MIRA research program (R35GM118173) are to 1) develop novel synthetic methods and expedient approaches to important, unstudied classes of bioactive natural products and to 2) explore fundamental questions of compound mechanism of action in clinical and translational research collaborations. The relevance to public health of the planned studies entails identification of novel, biologically active agents for use as pharmacological therapies for human cancers as well as viral, fungal, and bacterial illnesses.

PI_NAMEs: PORCO, JOHN A. (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-V(07)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Burden of Illness;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: BASTANI, ROSHAN  (contact)

PROJECT_TERMS: Address;Adopted;Affect;African American population;Age;anti-cancer research;Asian population;Attention;Basic Science;Cancer Burden;cancer care;Cancer Center Support Grant;cancer risk;Catchment Area;Characteristics;Clinical Research;Clinical Sciences;Clinical Trials;Colorectal Cancer;Communities;community engagement;community organizations;Community Outreach;Comprehensive Cancer Center;County;Death Rate;Disparity;economic indicator;end of life;Enrollment;ethnic diversity;ethnic minority;ethnic minority population;Ethnic Origin;Ethnic Population;evidence base;Future;Gender;Geographic Locations;Goals;Health;Healthcare;Home;Immigrant;implementation research;Incidence;Inequity;Institution;Insurance Coverage;Language;Latino Population;Liver;Los Angeles;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;marginalized population;Measures;member;minority communities;Mission;Monitor;mortality;NCI Center for Cancer Research;Not Hispanic or Latino;Outcome;outreach;Pacific Islander;Pancreas;Pattern;Play;Policies;Population;Population Group;Population Heterogeneity;Population Research;Population Sciences;Preventive vaccine;Primary Prevention;Race;racial minority;racial minority population;Research;Research Support;Resources;response;Risk Factors;Role;Science;Scientific Advances and Accomplishments;Screening for cancer;Shapes;socioeconomics;Stage at Diagnosis;Stomach;Survival Rate;trend;United States;vaccine acceptance;Vulnerable Populations;Work

PROJECT_TITLE: Community Outreach and Engagement


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Estrogen;Lung;Pulmonary Hypertension;Rare Diseases;Women's Health Research

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  In this proposal, we will investigate the hypothesis that sex-differences in RV function in PAH are in-part mediated by an inhibitory action of estrogen on microtubule dynamics. We will employ state of the art microscopy and computational analysis to define how estrogen regulates microtubules. Then, in translational studies we will determine modulation of the estrogen-microtubule interaction impacts right ventricular function in pre-clinical PAH using advanced hemodynamics and molecular phenotyping of the RV microtubule cytoskeleton.

PI_NAMEs: PRINS, KURT W (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Antiinflammatory Effect;Area;Binding;Biological Assay;Biomedical Engineering;Biophysics;Blood capillaries;Calcium;Cardiac Myocytes;Cells;Cessation of life;Computer Analysis;Computer Models;Cytoskeleton;Data;density;Disease;Down-Regulation;Echocardiography;Electron Microscopy;Endothelin;Estrogen Receptors;Estrogens;Exhibits;experimental study;Exposure to;Female;female sex hormone;Fibrosis;Fluorescence Microscopy;Grant;Growth;hemodynamics;Hypoxia;Impairment;improved;In Vitro;in vivo;Investigation;junctophilin;Knowledge;Lung;Maintenance;male;Mediating;Microscopy;Microtubule Polymerization;Microtubules;Mitochondria;Molecular;molecular phenotype;Monocrotaline;mortality;Pathologic;Pathway interactions;Phenotype;pre-clinical;pressure;Proteins;pulmonary arterial hypertension;pulmonary arterial pressure;Pulmonary artery structure;Pulmonary Vascular Resistance;Pulmonary vessels;Rattus;Regulation;response;Right Ventricular Dysfunction;right ventricular failure;Right Ventricular Function;Right ventricular structure;Risk Factors;Rodent;Role;Severities;Sex Differences;Signal Transduction;Stimulus;Stress;Structure;Techniques;Testing;trafficking;translational approach;translational study;Vascular Diseases;Ventricular;Women's Rights;Workload

PROJECT_TITLE: Multi-scale Investigation of Sex Differences in Right Ventricular Function via Estrogen-Microtubule Interactions

STUDY_SECTION: MPPA

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology A Study Section [MPPA]


NIH_SPENDING_CATS: Clinical Research;Diabetes

PI_NAMEs: COHEN, RONALD N (contact)

PROJECT_TERMS: Area;Award;Basic Science;catalyst;Chicago;Clinical Research;Decision Making;Diabetes Mellitus;Extramural Activities;Funding;Goals;Grant;Illinois;Institution;Investments;medical schools;novel;Obesity;posters;programs;Reporting;Research;Research Personnel;Source;Technology;Training;Translational Research;United States National Institutes of Health;Universities;Wisconsin;Writing

PROJECT_TITLE: P and F Program


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Genetics

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

PHR: PROJECT NARRATIVE Defective patterning and morphogenesis of human skin appendages—including hair and skin glands—leads to common heritable and acquired disorders that have profound effects on health and well-being of affected indi- viduals. This project introduces a novel and unusually accessible system, skin development in zebraﬁsh, for elucidating the molecular cues and fundamental cell behaviors that drive early stages of skin appendage mor- phogenesis and govern their spatial distribution in the skin. By imaging live dermal cells in intact animals while manipulating functions of biomedically relevant gene products, this work will provide novel insights into the fundamental biology of the skin and open new avenues for elucidating etiologies of hereditary and acquired skin appendage disorders. 1

PI_NAMEs: PARICHY, DAVID M (contact)

PROGRAM_OFFICER_NAME: BELKIN, ALEXEY

PROJECT_TERMS: Address;Affect;Animals;antagonist;appendage;Attention;Basement membrane;Biological Assay;Biological Models;Biology;Birds;cell behavior;cell motility;Cells;Chicken Model;Clinical;Complex;Coupled;Cues;Dedications;Dermal;Dermatology;Dermis;Development;Diffusion;Disease;Eccrine Glands;Ectodermal Dysplasia;Embryonic Development;Endowment;Epidermis;Epithelium;Etiology;Event;Experimental Models;experimental study;extracellular;Feathers;Fertilization;Fishes;gene product;Genetic;genetic analysis;genetic manipulation;Germ Lines;Gland;Hair;Health;Heritability;Human;Human Genetics;Image;in vivo evaluation;in vivo imaging;Individual;Infrastructure;Inherited;inhibitor;insight;Integumentary system;Lesion;Ligands;Link;Mammals;Mammary gland;Mediating;Medical;Mesenchymal;meter;Methods;Microsurgery;migratory population;Modality;Modeling;Molecular;molecular dynamics;Morphogenesis;mosaic;mouse model;NF-kappa B;novel;Organ;Output;Pathway interactions;Pattern;Personal Satisfaction;pharmacologic;Phenotype;Postembryonic;Reaction;Regenerative Medicine;Regulation;Research;Resolution;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Signaling Protein;Skin;skin disorder;skin fibrosis;skin organogenesis;Spatial Distribution;System;teleost fish;Testing;therapy design;therapy development;Time;Tissues;Tooth structure;transgene expression;transmission process;Vertebrates;WNT Signaling Pathway;Work;wound healing;Zebrafish

PROJECT_TITLE: Mechanisms of signal transmission in vertebrate skin appendage development.

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: TEITELL, MICHAEL A (contact)

PROJECT_TERMS: Acceleration;access disparities;anti-cancer research;Area;Award;Biophysics;Cancer Center Support Grant;cancer clinical trial;cancer immunotherapy;cancer research center director;Catchment Area;Clinical Research;Clinical Trials Network;commercialization;Communities;community center;community engagement;Community Outreach;Comprehensive Cancer Center;County;Development;Devices;disparity reduction;Early Intervention;Faculty;Faculty Recruitment;flexibility;Fostering;Foundations;Funding;Goals;Grant;Health;health care availability;innovation;Investments;Leadership;Los Angeles;Malignant Neoplasms;member;Metabolism;Mission;NCI Center for Cancer Research;Obesity;Phase;Play;prevent;Productivity;programs;recruit;Research;research faculty;research study;Resources;Role;Schools;Science;Source;Strategic Planning;theranostics;therapy development;tumor;Underserved Population

PROJECT_TITLE: Developmental Funds


NIH_SPENDING_CATS: Cancer

PROJECT_TERMS: Acceleration;Achievement;Address;anti-cancer research;Area;Automobile Driving;Basic Science;Cancer Center Support Grant;cancer education;cancer research center director;Catchment Area;Charge;Clinical;clinical care;Clinical Research;Clinical Sciences;Committee Members;Communication;Communities;community engagement;Community Outreach;Comprehensive Cancer Center;Counseling;County;Decision Making;Dedications;Doctor of Philosophy;Education;Education and Outreach;Evaluation;experience;Fostering;Foundations;Funding;Future;Goals;Growth;Growth and Development function;Health;Health Sciences;Height;Infrastructure;innovation;Institution;Lead;Leadership;Los Angeles;Malignant Neoplasms;Maps;member;Mentors;Mission;oncology service;organizational structure;patient oriented;Patient-Centered Care;Patients;Periodicals;Population Research;Population Sciences;prevent;Process;Productivity;programs;Published Comment;Reporting;Research;Research Priority;Resource Allocation;Resource Sharing;Role;Science;Series;Shapes;Strategic Planning;Structure;Study Section;success;Training;Training and Education;Translational Research;Vision;Work;working group

PROJECT_TITLE: Leadership, Planning and Evaluation


ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative This proposal develops a novel method for carrying out multiplexed measurements on large numbers of single cells. The methods developed will allow researchers to leverage new comprehensive “atlases" of tumor cells for a wide range of studies from evaluating the effects of new drug treatments, to identifying tumor cells that predict patient outcomes. Within this advanced development grant, we move from established technical capabilities to two mature fully-working methods for single cell analysis.

PI_NAMEs: KLEIN, ALLON MOSHE (contact);MAZUTIS, LINAS

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;Adoption;Advanced Development;Animals;anti-cancer research;Antibodies;aqueous;Atlases;Benchmarking;Biological;Biological Assay;Buffers;capsule;Cell surface;Cell Surface Proteins;Cells;Clinical Research;cohort;Complex;cost;Cytolysis;Cytometry;Development;digital;DNA;Enzymes;Evolution;Flow Cytometry;Fluorescence;Future;Gene Expression Profiling;Generations;Genes;Goals;Grant;high throughput screening;Hour;Image;Immobilization;improved;Individual;Measurement;Measures;Membrane Proteins;Messenger RNA;Methods;Microcapsules drug delivery system;microfluidic technology;Microfluidics;Molecular Biology;multiple omics;nanolitre;nanolitre scale;neoplastic cell;new technology;novel;novel therapeutics;Oils;Patient-Focused Outcomes;Patients;Performance;Periodicity;Permeability;Phenotype;Population;pre-clinical research;Preparation;Primary Neoplasm;Process;Prognosis;protein expression;Proteins;Protocols documentation;Publishing;Reaction;Research Personnel;resilience;Salts;Sampling;scale up;screening;Sensitivity and Specificity;Signal Transduction;single cell analysis;single cell genomics;single-cell RNA sequencing;Specificity;Speed;Stains;targeted treatment;Technology;Testing;Time;Transcript;Tube;tumor heterogeneity;tumor microenvironment;Tumor-infiltrating immune cells;Variant;Water

PROJECT_TITLE: Micro-capsules for versatile multiplexed cytometry


NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Nutrition;Prevention

ORG_DEPT: PHYSIOLOGY

PHR: Project Narrative/Relevance: Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the underlying cause of most heart attacks or stroke and are the leading cause of death in the United States and worldwide. Whereas there is general agreement that atherosclerosis is a chronic inflammatory disease, multiple large clinical trials of drugs that globally inhibit inflammation have failed to get FDA approval due to them having modest or no beneficial effects on the incidence of a fatal or non-fatal heart attack or stroke, and an increase in lethal infection because patients are immuno-compromised. We postulate that a major reason for the failure of global anti-inflammatory agents is because they inhibit not only detrimental chronic pro-inflammatory responses that exacerbate atherosclerosis, but also evolutionarily conserved beneficial acute inflammatory processes necessary for resistance to infection, resolution of inflammation, and tissue injury-repair processes important for enhancing the stability of atherosclerotic lesions and reducing the chance of rupture or erosion. Studies in this proposal will use novel mouse models and analysis methods to determine if selective inhibition of interleukin- 6 (IL-6) trans signaling, which is believed to be a key mediator of the transition from acute (beneficial) to chronic (detrimental) inflammation, promotes formation of more stable atherosclerotic lesions and a reduced probability of lesion rupture or erosion but without impaired immuno-competence. If so, results would be of major significance in that they would suggest that human clinical trials should focus on testing selective IL-6 trans inhibitors not global inhibitors of IL-6 responses as is currently the case with a recently initiated large Phase 3 clinical trial.

PI_NAMEs: OWENS, GARY K (contact)

PROGRAM_OFFICER_NAME: HASAN, AHMED A  K

PROJECT_TERMS: Acute;Adrenal Cortex Hormones;Adverse effects;Age;Agreement;Anti-Inflammatory Agents;Antibodies;Antibody Therapy;Aorta;Apolipoprotein E;Arterial Fatty Streak;Arteries;Atherosclerosis;blood lipid;Cardiovascular system;Cause of Death;Cell Count;Cell Lineage;Cell Separation;cell type;Cells;Cessation of life;Chronic;chronic inflammatory disease;Clinical;Clinical Trials;Collagen;Complex;Coronary artery;Coxibs;cytokine;Development;Diet;Disease;Disease Progression;Dose;Endothelial Cells;Event;expectation;Failure;Family;Fc Receptor;feeding;Frequencies;glycoprotein 130;high risk;Human;IL-6 inhibitor;IL6 gene;IL6ST gene;Immune;immune resistance;Immunocompetence;Immunocompromised Host;immunodeficiency;Impairment;Incidence;indexing;Infection;Inflammation;Inflammatory;Inflammatory Response;inhibitor;injury and repair;insight;Interleukin 6 Receptor;Interleukin-1 beta;Interleukin-1 Receptors;Interleukin-6;Intervention Studies;Investments;Knock-out;LDL Cholesterol Lipoproteins;Lesion;Lesion by Stage;Lipids;Macrophage;Maintenance;Mediator;Medicine;Methods;Methotrexate;mouse model;multiplexed imaging;Mus;Myocardial Infarction;Nature;neutralizing antibody;novel;older patient;Paper;pathogen;Pathogenesis;patient population;Patients;Pharmaceutical Preparations;Phase III Clinical Trials;Phenotype;Play;Prevention;primary endpoint;Probability;Process;protective effect;PTPRC gene;Receptor Signaling;Resistance to infection;Resolution;response;Role;Rupture;Safety;Secondary to;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Stroke;systemic inflammatory response;Tamoxifen;Testing;therapeutically effective;tissue injury;tissue repair;Transducers;United States;western diet

PROJECT_TITLE: Role of IL-6 trans signaling in atherosclerosis development and late-stage pathogenesis

STUDY_SECTION: AVI

STUDY_SECTION_NAME: Atherosclerosis and Vascular Inflammation Study Section[AVI]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety

PI_NAMEs: SLAMON, DENNIS J (contact)

PROJECT_TERMS: Address;authority;Awareness;Cancer Center;Cancer Center Support Grant;cancer clinical trial;cancer research center director;Catchment Area;Child;Clinical;Clinical Cancer Center;Clinical Data;Clinical Oncology;Clinical Protocols;Clinical Research;Clinical Sciences;Clinical Trials;Clinical Trials Data Monitoring Committees;Clinical Trials Design;Communities;Comprehensive Cancer Center;County;Data;Data Analyses;data management;Data Reporting;Development;Doctor of Philosophy;Education;Enrollment;Ensure;Evaluation;Faculty;FDA approved;federal policy;Funding;Goals;Gynecology;high standard;Hospitals;Improve Access;improved;Infrastructure;Institution;Institutional Policy;Intervention;Intervention Trial;investigator-initiated trial;Investments;Leadership;Los Angeles;Malignant Breast Neoplasm;Malignant Neoplasms;Medical center;meetings;member;Minority;Minority Groups;Monitor;Olives - dietary;Oncology;Patients;Performance;Population;Population Group;Principal Investigator;Procedures;Process;programs;protocol development;quality assurance;Quality Control;Reporting;Research;Research Activity;Research Personnel;Research Support;Safety;Secure;Standardization;Structure;System;Time;Time Study;Training;translational oncology;Translational Research;translational study;Underserved Population;Update;Woman;Work

PROJECT_TITLE: Clinical Protocol and Data Management


NIH_SPENDING_CATS: Cancer;Prevention

PI_NAMEs: GLASPY, JOHN A (contact)

PROJECT_TERMS: authority;Basic Science;Cancer Center Support Grant;Cancer Science;Catchment Area;Clinical;Clinical Research;Clinical Trials;Communities;County;Data;design;Diagnosis;Doctor of Philosophy;Ensure;experience;Goals;Guidelines;human subject;Infrastructure;Institution;Institutional Review Boards;Intervention;Intervention Trial;Jonsson Comprehensive Cancer Center of University of California Los Angeles;Leadership;Los Angeles;Malignant Neoplasms;Medical;medical specialties;meetings;member;Monitor;Oncology;participant enrollment;patient population;Patients;Peer Review;Prevention;Process;Protocols documentation;Provider;Regulation;Reporting;Research;research facility;Research Personnel;research study;Resources;Review Committee;Scientist;screening;sound;Specimen;Structure;System;Work

PROJECT_TITLE: Protocol Review and Monitoring System


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Mental Health

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PUBLIC HEALTH RELEVANCE A shortage of physician scientists investigating mental diseases threatens the US' ability to address population mental health challenges. This research education program aims to increase the number of psychiatrists pursuing a career in mental disorder research and to train them in research methods.

PI_NAMEs: MATHALON, DANIEL H;VOGLMAIER, SUSAN M. (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: academic program;Acceleration;Address;Area;aspirate;Attitude;Award;Basic Science;Behavioral Sciences;Biological Assay;Biomedical Research;California;career;career development;Child;Climate;Clinical;Clinical Research;Clinical Sciences;clinical training;clinically relevant;Communities;Community of Practice;Country;Creativeness;Dedications;Development;Development Plans;Disease;Doctor of Philosophy;Education;education research;Educational process of instructing;Environment;experience;Faculty;Feedback;Feeling;Fellowship;flexibility;Fostering;Functional disorder;Funding;Future;Genetic;Goals;Grant;hands on research;Individual;innovation;Institution;instrument;inter-institutional;interest;Journals;Knowledge;Lead;Leadership;Learning;literacy;meetings;member;Mental disorders;Mental Health;Mentors;Mentorship;Methodology;minority trainee;Motivation;Neurosciences;next generation;peer learning;Physicians;Population;Positioning Attribute;Process;process improvement;Productivity;Professional Competence;Program Development;programs;Psyche structure;Psychiatric therapeutic procedure;Psychiatrist;Psychiatry;public health relevance;Publications;Readiness;Records;recruit;Research;Research Activity;Research Domain Criteria;Research Ethics;Research Methodology;Research Personnel;Research Project Grants;Research Support;Research Training;Residencies;Resources;Rotation;Science;Scientific Advances and Accomplishments;Scientist;Secure;Series;Site;skills;social media;statistics;success;Targeted Research;Time;tool;Training;Training Activity;Training and Education;Training Programs;Translating;Translational Research;Travel;Underrepresented Minority;Wages;web site;Woman;Work;Writing

PROJECT_TITLE: TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERS


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: Chicago

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: The proposed research is relevant to public health because small-molecule tools that enable the study of autophagy modulation in the fatal, genetic disorder, Niemann-Pick Disease Type C (NPC), will provide a better understanding of the role of autophagy in lipid homeostasis and storage and the therapeutic potential of this strategy. The proposed research is also relevant to the fundamental goals of the NINDS to “understand how the normal brain and nervous system develop and work, and what goes wrong in disease, and to translate basic and clinical discoveries into better ways to prevent and treat neurological disorders”.

PI_NAMEs: COLOGNA, STEPHANIE M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Adolescence;Affect;analog;animal tissue;Animals;aqueous;Autophagocytosis;autosome;Biological Assay;Biological Process;Biology;biomarker identification;blood-brain barrier penetration;Brain;Cell Death;Cells;Cessation of life;Child;Cholesterol;Clinical;Communities;Complex;Development;Disease;Disease Progression;Dose;drug discovery;drug distribution;drug efficacy;Drug Kinetics;drug metabolism;efficacy evaluation;emerging adult;Evaluation;experimental study;extend lifespan;FDA approved;Fibroblasts;Gene Expression;Gene Expression Profiling;Genetic Diseases;Goals;Health;Homeostasis;Image;improved;In Vitro;in vivo;in vivo evaluation;innovation;knock-down;Label;Lead;lead optimization;life span;lipid transport;Lipids;Liver;Lysosomes;mass spectrometric imaging;Mass Spectrum Analysis;Measures;meter;Methods;Microsomes;Modeling;Mus;Mutant Strains Mice;Mutation;National Institute of Neurological Disorders and Stroke;Neimann-Pick's Disease Type C;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;novel;novel therapeutics;NPC1 gene;Organ;overexpression;Pathway interactions;Patients;Permeability;Phenotype;prevent;Property;Protein Analysis;Proteins;Proteomics;Public Health;Recycling;Regimen;Reporting;Research;Role;small molecule;Solubility;Symptoms;targeted treatment;Testing;Therapeutic;therapeutic development;Therapeutic Intervention;therapeutically effective;Time;tool;Translating;treatment response;Visceral;Work

PROJECT_TITLE: Development of autophagy modulators for evaluation as a therapeutic strategy for Niemann-Pick Type C

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


NIH_SPENDING_CATS: Biotechnology

ORG_CITY: BALTIMORE

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Cells can sense and move along shallow gradients of chemoattractants, a process that is essential for normal physiology in the embryo and adult as well as for the pathology of numerous diseases. These studies focus on the molecular mechanisms of motility and directed migration in normal and cancer cells. A thorough understanding of these processes will make it possible to interfere with them specifically in target cells and eventually lead to new therapeutic strategies for cancer and a host of other diseases.

PI_NAMEs: DEVREOTES, PETER N (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Acute;Address;Adult;Back;Biological;Biological Assay;cancer cell;cell behavior;Cell Death Induction;Cell Line;cell motility;cell transformation;Cells;Charge;Chemotactic Factors;computer studies;Coupled;Cytoskeleton;design;Dictyostelium;Disease;Embryo;Epithelial Cells;Face;genetically modified cells;Grant;Health;Image;inhibitor;Lipids;Location;Macrophage;Malignant Neoplasms;Mammalian Cell;Mediating;Membrane;Methods;migration;Modeling;Molecular;Monitor;Motility;neutrophil;Normal Cell;novel;novel therapeutic intervention;optogenetics;Organoids;Pathology;Pattern;Phagosomes;Phosphotransferases;Physiology;Process;Property;Protein Geranylgeranylation;Proteins;response;screening;Series;Signal Transduction;spatiotemporal;Starvation;Surface;System;tool;Vesicle

PROJECT_TITLE: Excitable Networks in Directed Cell Migration

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Hematology;Mental Health;Mental Illness;Neurosciences;Prevention;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE: Patients with hemophilia have significant bleeding events, but they also suffer from mental health disorders and demonstrate executive dysfunction more frequently than the general population. Our proposed studies aim to quantify volumetric brain differences, cerebral bleeds, and neuroinflammation to understand their impact on behavior outcomes. Understanding the neurophenotype in hemophilia may help in earlier screening, detection, and treatment of anxiety, depression, and neurocognitive deficits in hemophilia patients which would transform current patient care standards.

PI_NAMEs: STABER, JANICE MARIEROSE (contact)

PROGRAM_OFFICER_NAME: BAI, C BRIAN

PROJECT_TERMS: 3 year old;Address;Adult;Affect;Age;Amygdaloid structure;Anatomy;Animal Model;Anxiety;anxiety treatment;arthropathies;Behavior;behavior measurement;behavior test;Behavioral;behavioral outcome;behavioral phenotyping;Brain;brain abnormalities;Brain Diseases;Brain Injuries;Brain region;brain volume;Caring;Cerebellum;cerebral microbleeds;Cerebrum;Child;Chronic Disease;Cognitive;cohort;comorbidity;conditioned fear;Darkness;Data;design;Detection;Development;disability;Early Diagnosis;early screening;Event;Executive Dysfunction;Exhibits;experimental study;Factor VIII;Frequencies;Functional disorder;Gene Transfer Techniques;General Population;glial activation;Goals;Health;Hemophilia A;Hemorrhage;Hippocampus;Histologic;human disease;Hypothalamic structure;imaging study;improved;Incidence;Infant;Injections;innovation;insight;Intracranial Hemorrhages;joint injury;Joints;Lead;Light;Link;Measures;Mental Depression;Mental disorders;Meta-Analysis;Modeling;Mononuclear;mouse model;Mus;Myopathy;neonatal period;Nervous System Disorder;Nervous System Physiology;Neuroanatomy;neurobehavioral;Neurocognitive;Neurocognitive Deficit;neuroimaging;neuroinflammation;Neurologic;Neurological outcome;Neuropathogenesis;neuropsychiatric disorder;neuropsychiatry;Non-Viral Vector;novel therapeutics;Outcome;Pathway interactions;Patient Care;Patients;Persons;Phenotype;prevent;Prevention;Prevention strategy;Preventive;Process;prophylactic;Prophylactic treatment;Publishing;Quality of life;Reporting;Research;Review Literature;Risk;Role;Schedule;sex;Signs and Symptoms;standard of care;Stress;Structure;Testing;Time;Tissues;Wild Type Mouse;Work

PROJECT_TITLE: Understanding of a neurophenotype in hemophilia A


NIH_SPENDING_CATS: Aging;Building Research Capacity at Institutions with Limited NIH Funding;Eye Disease and Disorders of Vision;Neurosciences;Sleep Research

ORG_CITY: ATLANTA

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: The widespread control of signaling, metabolism, and gene expression exerted by the retinal circadian clock which contributes to many types of retinal diseases. The experiments proposed in our application will elucidate the role of retinal clock in cell viability, neural circuitry and behavior rhythm.

PI_NAMEs: BABA, KENKICHI  (contact)

PROJECT_TERMS: Acceleration;Affect;Aging;aging process;Antioxidants;ARNTL gene;Behavior;Behavior Control;Bilateral;blind;Brain;Brain-Derived Neurotrophic Factor;catalase;Cell Death;Cell Death Induction;Cell Line;Cell model;Cell Survival;Cells;Cessation of life;circadian;Circadian desynchrony;Circadian Dysregulation;circadian pacemaker;Circadian Rhythm Disorder;Circadian Rhythms;Cone;Couples;Darkness;Data;Defect;Dendrites;Environment;Excision;experimental study;Eye diseases;Eye Enucleation;Gene Expression;Genes;Genetic;Glial Fibrillary Acidic Protein;glutathione peroxidase;Goals;Hamsters;insight;Jet Lag Syndrome;Knockout Mice;Life;Lipids;Metabolism;Molecular;molecular clock;Morphology;Motor Activity;Mus;neural circuit;neuronal circuitry;Neuronal Plasticity;Ocular Pathology;old mice;Organism;Output;oxidation;Oxidative Stress;Oxidative Stress Induction;Pathology;Periodicity;peroxiredoxin;Photoreceptors;Physiology;Population;Reactive Oxygen Species;real time monitoring;Regulation;Research;response;Retina;Retinal Cone;Retinal Diseases;retinal neuron;Retinal Photoreceptors;Role;Series;shift work;Signal Transduction;suprachiasmatic nucleus;Tamoxifen;Techniques;Technology;Testing;Transgenic Mice;Vision;Visual;Work

PROJECT_TITLE: The retinal clock modulates cell viability, retinal circuitry and locomotor activity rhythm