NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Nearly all persons with Down syndrome will develop Alzheimer’s disease at some point in their lives and understanding predictive biomarkers before symptom onset is critical in order to design and apply preventative treatments. Here we integrate advanced multimodal neuroimaging and fluid biomarkers to predict Alzheimer’s disease neuropathology and hallmark neuropsychological symptoms before the onset of dementia. Not only will the results of this project be informative toward the development of treatments for persons with Down syndrome, it will also be useful in understanding Alzheimer’s disease in the general population.

PI_NAMEs: BRUNO, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Adult;Age;Aging;aging biomarker;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Biological Markers;biophysical properties;Brain;Brain Pathology;Brain region;brain tissue;career;Clinical;clinical translation;Cognitive;cohort;Computing Methodologies;connectome;connectome based predictive modeling;Corpus striatum structure;Data;Dementia;design;Development;Diagnosis;Diffusion;Diffusion Magnetic Resonance Imaging;Dimensions;Disease Progression;Down's Syndrome;Enrollment;executive function;follow-up;Functional Magnetic Resonance Imaging;General Population;Goals;Hippocampus;in vivo;Individual;innovation;insight;Intervention;K-Series Research Career Programs;Knowledge;life span;lifetime risk;Light;Liquid substance;Magnetic Resonance Imaging;Measures;Memory;mild cognitive impairment;model generalizability;multimodal neuroimaging;multimodality;Nerve Degeneration;neurofilament;neuroimaging;neuropathology;neuropsychiatry;Neuropsychology;Neurosciences;novel;Outcome;Pathologic;Pathology;Patients;Pattern;Persons;Phenotype;Plasma;Population;Positron-Emission Tomography;predictive marker;Preventive treatment;Property;Research Personnel;Rest;skills;social cognition;Spectrum Analysis;Structure;Symptoms;tau Proteins;Testing;therapy development;Training;Translational Research;Validation;vector;Work

PROJECT_TITLE: Toward a neuroscientific understanding of the interaction between Down syndrome and Alzheimer's disease pathology

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PI_NAMEs: VRANCEANU, ANA-MARIA  (contact)

PROJECT_TERMS: Academy;Address;Affect;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Area;Award;behavior change;Behavior Therapy;behavioral health;behavioral health intervention;Behavioral Research;Benchmarking;Biological;Biological Markers;Biology;Black race;Boston;career;career development;Caring;Centers for Disease Control and Prevention (U.S.);Clinic;Clinical;Collaborations;Communities;community engaged research;community partnership;community setting;Data;Dementia;dementia burden;dementia risk;Development;Development Plans;Diagnosis;digital health;Disease;disorder prevention;education research;Ensure;ethnic minority;Evaluation;Faculty;First Generation College Students;Fostering;Funding;General Hospitals;Goals;Grant;Growth;Health Alliance;Health Disparities Research;health disparity;Hospitals;human old age (65+);informal care;Infrastructure;Institution;interest;Knowledge;Latino;Lead;Leadership;Link;Massachusetts;Measurement;Medical center;Medicine;Mentors;Mentorship;Minor;Minority;Minority Groups;Minority Health Research;minority patient;Minority Recruitment;Modeling;Names;Neuropsychology;novel;older adult;Participant;Patients;Persons;Pilot Projects;Population;Prevention;Preventive;Primary Prevention;Process;programs;Psychologist;Qualitative Evaluations;racial minority;recruit;Research;Research Personnel;research study;Resource Sharing;Resources;Science;Scientific Advances and Accomplishments;Scientist;Secondary Prevention;statistics;success;symposium;tertiary prevention;Testing;therapy development;Time;training opportunity;Translating;United States National Institutes of Health;Universities;Woman;Work

PROJECT_TITLE: Research Education Component (REC)


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Duchenne/ Becker Muscular Dystrophy;Gene Therapy;Genetics;Heart Disease;Muscular Dystrophy;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Failing of respiratory and heart function is the leading cause of mortality in Duchenne muscular dystrophy patients. Adeno-associated virus (AAV)-mediated gene editing therapy is a highly promising approach to treat the underlying cause of muscle and heart dysfunction in DMD. This project aims to develop a controllable base editing therapy with improved safety for DMD.

PI_NAMEs: HAN, RENZHI  (contact)

PROGRAM_OFFICER_NAME: LI, HUIQING

PROJECT_TERMS: Adenine;adeno-associated viral vector;adeno-associated virus 9 delivery;adenovirus mediated delivery;Animal Model;Animals;Antigen-Presenting Cells;Basal lamina;base;base editing;base editor;Binding Sites;Biology;Birth;boys;Capsid;Cardiac;Cardiomyopathies;Cells;Clinical;clinical translation;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combat;Complex;CRISPR/Cas technology;Cytoskeleton;Data;Degenerative Disorder;Dependovirus;design;Disease;disease-causing mutation;DNA;DNA Double Strand Break;DNA Sequence Alteration;Dose;Duchenne muscular dystrophy;Dystrophin;efficacy evaluation;Elements;Embryo;Engineering;Event;Exons;experimental study;extend lifespan;Frequencies;Friends;gene editing technology;Gene Expression;Gene Rearrangement;Genes;Genetic;genome editing;Genomics;genotoxicity;Germ Cells;Glycoproteins;Guide RNA;Heart failure;heart function;Human;human disease;Immune;Immune response;Immune system;Immune Tolerance;Immunity;immunoengineering;immunogenic;immunomodulatory strategy;improved;in vivo;insight;Knowledge;Light;male;manufacture;Mediating;MicroRNAs;Modeling;Monitor;mortality;mouse model;Mus;Muscle;Muscle function;Muscular Dystrophies;Muscular dystrophy cardiomyopathy;mutant;Mutation;Myocardial dysfunction;Myocardium;Myopathy;Nonsense Mutation;novel;novel strategies;Oryctolagus cuniculus;Patients;Pharmaceutical Preparations;pharmacologic;Play;Point Mutation;Positioning Attribute;precision medicine;Proteins;Reading Frames;repaired;Research;Residual state;respiratory;Respiratory physiology;restoration;Role;Safety;Skeletal Muscle;Specificity;Steroids;Striated Muscles;System;TANK-binding kinase 1;Technology;Therapeutic;therapeutic development;therapeutic genome editing;TLR9 gene;Transcript;transcriptomics;transduction efficiency;transgene expression;Treatment Efficacy;Tumorigenicity;vector;ventilation;Viral Genome;Viral Packaging;Viral Vector

PROJECT_TITLE: Controllable base editing therapy for DMD

STUDY_SECTION: SMEP

STUDY_SECTION_NAME: Skeletal Muscle and Exercise Physiology Study Section[SMEP]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: La Jolla

ORG_NAME: SALK INSTITUTE FOR BIOLOGICAL STUDIES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Fluctuations in spiking activity are a hallmark of the neocortex, and prior studies conducted in the visual cortices of anesthetized animals found that variation in the stimulus evoked response can be predicted, based on intrinsic fluctuations in the depolarization state of neurons in the surrounding network, which often take the form of intrinsically generated traveling waves (iTWs). In the prior round of funding, we discovered that iTWs also occur in the awake state, and that they strongly and conjointly modulate both the strength of sensory evoked responses and the ability of the animal to detect a visual stimulus presented at perceptual threshold. In this competitive renewal, our collaborative team will test competing theory-driven predictions to understand the neural mechanisms that give rise to iTWs, their putative role in sensory discrimination, whether they induce deleterious information-limiting correlations in spiking activity, and whether they enable a new form of feature-selective sampling of the sensory environment.

PI_NAMEs: MULLER, LYLE EDWARD;REYNOLDS, JOHN H (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TITLE: Spatiotemporal patterns of neural activity and their role in perception

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Disability Research;Neurosciences

ORG_CITY: IOWA CITY

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Despite advances in understanding the causes of several neurological disorders, many remain without treatment options. Continuing the work of the NeuroNEXT Data Coordinating Center and adding new innovations to its rigorous processes will expedite the translation of scientific breakthroughs into neurological treatments.

PI_NAMEs: COFFEY, CHRISTOPHER S. (contact)

PROGRAM_OFFICER_NAME: OHAYON, JOAN M

PROJECT_TERMS: Adult;Affect;Age;Applications Grants;Area;Biometry;Childhood;Clinical;clinical biomarkers;Clinical Investigator;Clinical Research;clinical research site;Clinical Trials;Clinical Trials Network;cognitive disability;Collaborations;Common Data Element;Communication;Communication Tools;Community Networks;Conceptions;Data;Data Collection;Data Coordinating Center;data management;data quality;Data Security;data sharing;design;Development;disability;Discipline;Disease;distributed data;early phase clinical trial;early phase trial;Education;Ensure;Evaluation;experience;Foundations;Funding;Future;gene therapy;gene-targeted therapy;Goals;graduate student;improved;Industry;Information Technology;Infrastructure;innovation;Iowa;Lead;Leadership;Methodology;Monitor;mortality;Multicenter Trials;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;Neurologic;Neurosciences;operation;Participant;participant enrollment;Patients;Persons;physically handicapped;Population;Positioning Attribute;Principal Investigator;Process;Protocols documentation;Publications;quality assurance;Randomized;Reporting;Request for Applications;Research;Research Design;Research Personnel;Safety;Science;Secure;Site;Standardization;success;System;Therapeutic;tool;Traineeship;Training and Education;Training Programs;Translating;Translations;trial design;United States;Universities;web platform;Work

PROJECT_TITLE: Network of Excellence in Neuroscience Clinical Trials (NeuroNEXT)  DCC


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: JOO, JIN HUI  (contact)

PROJECT_TERMS: Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavior Therapy;behavioral health;Behavioral Research;Black Populations;Black race;Boston;Caregivers;Caring;Common Data Element;Communities;community collaboration;community engagement;comparative effectiveness;Consensus;Data;Data Element;Dementia;dementia risk;Development;digital;digital divide;education research;Educational Curriculum;Enrollment;Evaluable Disease;Evaluation;Event;Federally Qualified Health Center;Fostering;Funding;Future;Health;health disparity;health empowerment;Health Personnel;high risk;Hospitals;implementation evaluation;Individual;Intervention Studies;Latino;Latino Population;Learning;literacy;Massachusetts;Measures;member;Mentors;Methods;Minority;Minority Groups;Minority Health Research;Modeling;Neighborhoods;New England;Newsletter;Ontology;Participant;participant enrollment;Patients;personalized approach;PhenX Toolkit;Pilot Projects;Population;Prevention;primary outcome;Procedures;Protocols documentation;Publishing;Randomized;recruit;recruitment science;Reporting;Research;Research Personnel;Resources;retention rate;Risk;Science;Scientist;screening;Sequential Multiple Assignment Randomized Trial;Series;Site;social health determinants;Statistical Methods;Telephone;Testing;Training;Translating;trial design;Trust;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Community Liaison and Recruitment Core (CLRC)


ADMINISTERING_IC: OD

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Obesity;Pediatric;Pregnancy;Racial and Ethnic Minority Health Research

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: NARRATIVE Since the year 2000, the Asian population in the U.S. has nearly doubled and 6.5% of all births are to Asian people, however, a recent ECHO Cohort analysis of nearly 22,000 pregnancies reported only 5.0% to be among Asians, representing just over 1,000 pregnant Asian people. This proposal aims to increase the power and significance of the ECHO Cohort by enrolling an additional 780 pregnant Asian people representing multiple underrepresented Asian ethnic groups from the three largest healthcare systems in the Minneapolis/ St. Paul metropolitan area, along with their conceiving partners and index infants; 117 (15%) of these once- pregnant Asian persons and their conceiving partners will also be enrolled into the ECHO Pre-Conception Pilot. This unprecedented collaboration of health researchers will leverage our team’s outstanding performance in the first round of ECHO to achieve the specific aims of this project and to fulfill the ECHO Program’s aim to diversify the ECHO Cohort.

PI_NAMEs: NGUYEN, HONG-NGOC B. (contact)

PROGRAM_OFFICER_NAME: LAESSIG, SUSAN ALISON

PROJECT_TERMS: Advocate;aged;anti-Asian;Area;Asian;Asian Americans;Asian population;Attitude;Belief;Birth;Body Composition;Body mass index;cancer survival;Cardiometabolic Disease;Chemical Exposure;Chemicals;Child;clinical epidemiology;Clinical Research;cohort;Cohort Analysis;Collaborations;Collection;Communities;community engaged approach;Conceptions;Couples;Data;Data Element;Enrollment;Environment;Environmental Health;environmental health disparity;Ethnic Origin;Ethnic Population;Failure;Family;Fetal Development;Health;health data;Health Professional;Healthcare;Healthcare Systems;improved;indexing;Individual;Infant;Infant Development;Institution;Intervention;Knowledge;Life Style;Literature;Measures;Medical;Medical Research;Methodology;metropolitan;middle childhood;Minnesota;Minority;Minority Groups;Modeling;Modification;multi-ethnic;National Health and Nutrition Examination Survey;novel;Obesity;Outcome;Pacific Islander;Participant;Pediatric cohort;Performance;Persons;phthalates;Pregnancy;pregnant;Prenatal care;programs;Publishing;Race;racial difference;racial population;Recommendation;recruit;Reporting;reproductive;Research;Research Personnel;Risk;Role;sexual dimorphism;southeast Asian;Stigmatization;Subgroup;success;Transcend;Underrepresented Populations;Universities;Urine;Visit;Weight;Woman

PROJECT_TITLE: The ECHO Minnesota Asian American and Pacific Islander Pre-Conception and Pregnancy Cohort

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EPH-S(50)R]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Mental Health;Pediatric;Social Determinants of Health

ORG_NAME: JOSLIN DIABETES CENTER

PHR: PROJECT NARRATIVE Despite advances in diabetes technologies, such as continuous glucose monitors, few adolescents and young adults (AYA) with type 1 diabetes (T1D) attain glycemic targets. The proposed series of research studies seeks to develop, iteratively refine, and pilot test a psychosocial ambulatory glucose [PAG] intervention aimed at helping AYA with T1D to better interpret and behaviorally respond to out-of-range glucose values. This K23 application aims to investigate this important area of research and provide mentored career development for Dr. Amit Shapira in order to promote her trajectory towards an independent behavioral science diabetes research career focused on improving biomedical and psychosocial outcomes for people with T1D.

PI_NAMEs: SHAPIRA, AMIT  (contact)

PROGRAM_OFFICER_NAME: THORNTON, PAMELA L

PROJECT_TERMS: acceptability and feasibility;Adolescent;Adolescent and Young Adult;Affect;aged;Area;Behavior;Behavior Therapy;Behavioral;Behavioral Sciences;Blood Glucose;blood glucose regulation;career;career development;Caring;catalyst;Clinical;contextual factors;Continuous Glucose Monitor;Control Groups;Coupled;dashboard;Data;Data Collection;Development Plans;diabetes distress;Diabetes Mellitus;diabetes self-management;Distress;Doctor of Philosophy;Ecological momentary assessment;Emotional;emotional distress;Encapsulated;Evaluation;experience;Feedback;Fingers;Future;Glucose;Glycosylated hemoglobin A;Goals;group intervention;human centered design;improved;improved outcome;innovation;Insulin-Dependent Diabetes Mellitus;Intervention;intervention program;Interview;Investigation;life span;meetings;Mentors;Methods;Modality;Modernization;Monitor;multi-component intervention;multidisciplinary;novel;Outcome;Participant;Pattern;peer;Persons;pilot test;post intervention;precision medicine;Program Development;programs;Protocols documentation;psychosocial;psychosocial outcome;Qualitative Research;Randomized;Randomized, Controlled Trials;Regulation;Research;Research Personnel;research study;Risk;Sampling;satisfaction;Self Care;Series;skills;social;Social Environment;Standardization;Statistical Methods;Structure;Surveys;Technology;Testing;Time;tool;trend;usability;Vacuum;Visual;vulnerable adolescent;willingness

PROJECT_TITLE: Precision Monitoring: Understanding Momentary Affect, Glucose, and Self-care Behaviors in Adolescents and Young Adults with type 1 diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Clinical Research

ORG_CITY: LA JOLLA

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: PROJECT NARRATIVE Neutrophils are white cells that circulate in the blood and play an essential role in protecting us from microbial infections through the production and release of substances that are toxic to invading microorganisms. These toxic products, when released in large amounts or in an uncontrolled manner, can be harmful to the host (humans). The study of the mechanisms that control the release of toxic products by neutrophils will lead to the design of therapeutic strategies for the control of inflammatory disorders and infectious processes including cardiovascular disease and sepsis.

PI_NAMEs: CATZ, SERGIO DANIEL (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Actins;Affect;Attenuated;Autoimmune Diseases;autoinflammatory diseases;Autophagocytosis;Azurophilic Granule;Binding;Biological Assay;Blood;Calcium;Cardiovascular Diseases;Cicatrix;clinical application;Cytoplasmic Granules;Cytoskeleton;Data;Defect;defense response;design;Development;Disease;Docking;Endosomes;Endothelium;Endotoxemia;Event;Exocytosis;extracellular;Gene Modified;Goals;Grant;granulocyte;Homeostasis;Homologous Gene;Host Defense;Human;Immunity;in vivo Model;Infection;Infiltration;Inflammation;Inflammatory;Infrastructure;inhibitor;Innate Immune Response;innovation;Invaded;late endosome;Leukocytes;live cell microscopy;Mediating;Mediator;Methods;microbial;microorganism;Mitochondria;Mitochondrial DNA;Mitochondrial RNA;Molecular;Monomeric GTP-Binding Proteins;mouse model;Natural Immunity;neutrophil;Neutrophil Activation;novel;Nucleic Acids;Organelles;Pathogenicity;Pathway interactions;Peptides;Phagocytosis;Phagosomes;Physiological;Physiology;Play;Poison;pre-clinical;prevent;Process;Production;Proteins;Refractory;Regulation;Reperfusion Injury;Research;response;Role;secretory protein;sensor;Sepsis;Signal Transduction;small molecule;small molecule inhibitor;SNAP receptor;Specificity;Sterility;Structure-Activity Relationship;syntaxin;syntaxin 4;Systemic infection;systemic inflammatory response;Systems Biology;Systems Development;Testing;Therapeutic;Toxic Neutrophil;trafficking;translational approach;treatment strategy;ultra high resolution;Validation;Vascular Diseases;Vesicle;vesicle transport;Wiskott-Aldrich syndrome protein

PROJECT_TITLE: Vesicular trafficking mechanisms regulating granulocyte function

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-B(02)M]


ORG_CITY: NEW YORK

ORG_DEPT: NEUROLOGY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE The Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities will provide a reparative mentoring and leadership program, ADRD equity research training, pilot funding, and interdisciplinary collaboration to early career investigators from backgrounds that have been historically excluded in ADRD research. Our goal is to accelerate innovative research on the mechanisms of inequalities in ADRD, including biological, behavioral, sociocultural, environmental risk and resilience factors, biomarkers, and caregiving.

PI_NAMEs: BRICKMAN, ADAM M;MANLY, JENNIFER JAIE (contact)

PROGRAM_OFFICER_NAME: BANDIERA, FRANK

PROJECT_TERMS: Acceleration;Accountability;African American;African American population;Aging;aging brain;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Awareness;Behavioral;Behavioral Research;Bioinformatics;Biological;Biological Markers;career;career development;caregiving;Cities;Clinical Trials;Collaborations;college;Communication;community engaged research;community engagement;community partners;Country;Dementia;dementia burden;dementia caregiving;Dental;design;Direct Costs;Discipline of Nursing;disease disparity;Disparity;education research;Educational workshop;Ensure;Environmental Risk Factor;Equity;Evaluation;Exclusion;Family;frailty;Funding;Goals;Grant;Health;health disparity;Impaired cognition;implementation science;Incidence;Inequality;innovation;Institution;interdisciplinary collaboration;Interdisciplinary Study;interest;International;Internships;Latino;Latinx;Leadership;Life Cycle Stages;Longitudinal, observational study;Measures;Medical center;Medicine;Mental Health;Mentors;Mentorship;Methods;Minority;minority investigator;Minority-Serving Institution;New York;New York City;Not Hispanic or Latino;novel;Outcome;Pathway interactions;Physicians;Pilot Projects;Policies;Population;Prevalence;Production;programs;Psychometrics;Public Health;Quality of life;racism;Regulation;Research;Research Institute;Research Personnel;Research Training;resilience factor;Resources;Risk Factors;Schools;Scientist;Sexism;skills;social;social culture;social disparities;social health determinants;Social Work;sociocultural determinant;Stress;Surgeon;System;therapy design;Training;Translations;Universities;Vascular Dementia

PROJECT_TITLE: Columbia Center for Interdisciplinary Research on Alzheimer's Disease Disparities (CIRAD)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences

PI_NAMEs: MANLY, JENNIFER JAIE (contact)

PROJECT_TERMS: Acceleration;Address;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Behavioral;Biological;Biological Markers;career;career development;caregiving;Cities;Collaborations;college;Communication;Communities;community engagement;community organizations;community partners;community partnership;Country;Data;Data Science;data sharing;Dental;Discipline of Nursing;disease disparity;Disparity;Educational workshop;Ensure;Equity;Exclusion;experience;Faculty;Funding;Goals;health disparity;Height;Individual;Infrastructure;innovation;Institution;Institutional Review Boards;Interdisciplinary Study;International;Leadership;Medical center;Medicine;meetings;member;Mentors;Mentorship;Minority;Minority-Serving Institution;Monitor;National Institute on Aging;New York;New York City;Participant;Physicians;Pilot Projects;Policies;Population;Process;programs;Public Health;recruit;recruitment science;Research;Research Institute;Research Personnel;resilience factor;Resource Development;Resources;Risk Factors;Schools;Scientist;social culture;success;Surgeon;symposium;Techniques;Training;Training Support;United States National Institutes of Health;Universities;Washington

PROJECT_TITLE: Leadership and Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

PI_NAMEs: TERESI, JEANNE A. (contact)

PROJECT_TERMS: Academic Medical Centers;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;analytical method;Applications Grants;Behavior;Behavioral;Behavioral Sciences;Bioinformatics;Biological;Biological Markers;Biometry;Black Populations;Capsicum;Caregivers;caregiving;Cataloging;Characteristics;Clinical Trials;Cognitive;Cognitive aging;Collaborations;computerized data processing;Consultations;cost;Data;Data Analyses;data management;Data Set;dementia caregiving;Development;Discrimination;disease disparity;Disparity;Disparity population;Education;education research;Educational workshop;Environmental Risk Factor;Epidemiology;Equation;ethnic diversity;ethnic minority;Evaluation;Evaluation Studies;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;functional decline;functional outcomes;Funding;Goals;Health;health disparity;Hispanic Populations;Impaired cognition;Individual;Institution;instrument;Interdisciplinary Study;Internships;Investigation;K-Series Research Career Programs;Life Cycle Stages;Linguistics;longitudinal analysis;Measurement;Measures;Mediator;medical schools;Mental Health;Mentors;method development;Methodology;Methods;Minority;Modeling;Modernization;Neighborhoods;Neuropsychology;Not Hispanic or Latino;Outcome;Performance;Persons;Population;Population Heterogeneity;Production;Property;Psychometrics;Publications;Recommendation;Research;Research Design;Research Personnel;Research Project Grants;resilience factor;Resources;response;Risk Factors;Role;Scholars Program;Scientist;serial imaging;Site;skills;social;social culture;social determinants;social factors;social health determinants;Structure;Techniques;theories;Training;training opportunity;Training Programs;web site;Work

PROJECT_TITLE: Analysis Core


ADMINISTERING_IC: DC

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Building Research Capacity at Institutions with Limited NIH Funding;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hearing Loss;Networking and Information Technology R&D (NITRD);Neurosciences;Prevention;Primary Health Care;Social Determinants of Health

ORG_CITY: WASHINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GALLAUDET UNIVERSITY

ORG_STATE: DC

PHR: PUBLIC HEALTH RELEVANCE Community health workers and navigators (CHWs) can play a role in public education and  outreach for health equity within the deaf, deafblind, and hard of hearing (DDBHH) community.  In addition, because many cancer screening guidelines vary based on family history and  personal risk factors, CHWs are in a position to provide information about screening services  that helps to improve DDBHH patients’ cancer knowledge and risk perception, and adherence to  screening guidelines.

PI_NAMEs: KUSHALNAGAR, POORNA  (contact)

PROGRAM_OFFICER_NAME: COOPER, JUDITH

PROJECT_TERMS: Address;Adherence;Advanced Malignant Neoplasm;Age;American Sign Language;Appointment;cancer care;cancer diagnosis;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;Caring;Clinical;Clinical Services;Communication;Communities;Community Health;Community Health Aides;computer science;cost;Cultural Anthropology;deaf;Deafblind;Disability research;Education;Education and Outreach;Educational Curriculum;Eligibility Determination;Engineering;Enhancement Technology;Environment;experience;Face;Family;Funding;hard of hearing;Health;Health Care Reform;health disparity;health equity;health inequalities;health literacy;Healthcare;Healthcare Systems;Hearing;hearing impairment;Human;improved;improved outcome;Individual;innovation;insight;Instruction;Internet;Intervention;Knowledge;Label;Learning;Libraries;Linguistics;literacy;Literature;long-standing disparities;Malignant Neoplasms;marginalization;medically underserved;Medicine;mobile application;new technology;Oncology;Outcome;patient assistance;patient navigator;patient oriented;Patients;Performance;Persons;Physicians;Population;Positioning Attribute;Prevention;Printing;Provider;provider communication;public education;Public Health;Public Health Informatics;public health relevance;Questionnaires;Recording of previous events;Reduce health disparities;Report (document);Reporting;Research;Resources;Risk Factors;risk perception;screening;Screening for cancer;screening guidelines;Screening procedure;Screening Result;screening services;skills;social factors;social health determinants;support tools;System;Technology;technology development;technology platform;Text;tool;Training;Translating;transmission process;tutoring;Underserved Population;United States;United States National Institutes of Health;virtual;Vision;vocalization;web app;Work

PROJECT_TITLE: Using technology-enhanced approaches to advance cancer health equity among diverse deaf, deafblind, and hard of hearing populations.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);American Indian or Alaska Native;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: AIELLO, ALLISON E (contact)

PROJECT_TERMS: Address;Aging;Alaska Native;Alzheimer's Disease;Alzheimer's disease related dementia;American Indians;Applications Grants;Area;Award;Awareness;Behavioral;Behavioral Sciences;Bioinformatics;Biological;Biological Markers;Biometry;Black Populations;career;career development;caregiving;Cities;Clinical Trials;college;community engagement;Competence;Country;Data Set;Development;disease disparity;Disparity;education research;Educational workshop;empowerment;Ensure;Environmental Risk Factor;Epidemiologist;Epidemiology;Equity;Evaluation;Exclusion;experience;Faculty;Funding;Goals;Grant;Health;Health equity research;health inequalities;Individual;Inequality;innovation;Institution;Interdisciplinary Study;K-Series Research Career Programs;Latinx;Leadership;Life Cycle Stages;Measurement;Measures;Medicine;meetings;Mental Health;Mentors;Mentorship;minority investigator;minority scientist;Minority-Serving Institution;Monitor;multidisciplinary;National Institute on Aging;Neuropsychology;New York;New York City;outreach;peer networks;Persons;Pilot Projects;Population;Process;programs;Psychometrics;recruit;Research;Research Methodology;Research Personnel;research study;resilience factor;Resources;Schools;Science;Scientist;skills;social culture;social health determinants;sound;structural determinants;success;Training;Training Support;Universities;Writing

PROJECT_TITLE: Research Education Component


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Peripheral Neuropathy;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Traumatic Head and Spine Injury

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE  The disruption of connections between neurons in traumas like spinal cord injury and diseases like glaucoma results in severe dysfunction. The long-term consequences of these insults are determined by a genetic “injury response” program that has the capacity to both help and harm. The proposed experiments aim to understand a newly discovered branch of this genetic program to generate opportunities for improving neuronal survival and repair.

PI_NAMEs: WATKINS, TRENT  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: activating transcription factor 4;Acute;Address;Adult;Afferent Neurons;Alzheimer's Disease;Apoptosis;Apoptotic;arm;Axon;axon growth;axon injury;axon regeneration;axonopathy;Axotomy;Binding;biological adaptation to stress;Cells;Cellular Stress;chemotherapy induced neuropathy;Complex;conditional knockout;Data;Disease;Dissection;Drug Targeting;Engineering;Exhibits;experimental study;Failure;Feedback;Functional disorder;functional restoration;Gene Expression;Genes;Genetic;Genetic Transcription;Glaucoma;Goals;improved;In Vitro;in vitro Model;in vitro regeneration;in vivo;in vivo evaluation;Induction of Apoptosis;injured;Injury;insight;Intervention;JUN gene;knock-down;Knockout Mice;Laboratories;Leucine Zippers;loss of function;MAP Kinase Modules;Mediating;Mediator;Memory;Mitogen-Activated Protein Kinases;Modeling;Molecular;Natural regeneration;Nerve Crush;nerve damage;Nerve Degeneration;Neurodegenerative Disorders;neuron apoptosis;neuron loss;Neuronal Injury;neuronal survival;Neurons;neuroprotection;novel;novel therapeutics;old mice;Optic Nerve;Optic Nerve Injuries;Optics;Outcome;overexpression;Pathology;Pathway interactions;Peripheral nerve injury;Peripheral Nervous System Diseases;Phosphotransferases;Play;preservation;programs;Recovery;regeneration potential;regenerative;Regenerative response;Regulation;repaired;response;response to injury;retinal neuron;Role;screening;Sensory;Signal Transduction;single nucleus RNA-sequencing;Small Interfering RNA;Spinal cord injury;Stress;Testing;Therapeutic;transcription factor;Translations;Trauma;Up-Regulation

PROJECT_TITLE: Molecular Dissection of the Axonal Injury Response for Regeneration and Neuroprotection

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Maternal Health;Nutrition;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: LAS VEGAS

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE  This project uses a community-based participatory approach to promote the maternal-child component of an  existing comprehensive social intervention addressing social determinants of health to mitigate structural  racism amid COVID-19 in historically racial/ethnic marginalized communities in the Southwest US. We will use  racial equity frameworks to co-create WITH the community and implement a system-level intervention to  integrate maternal-child health and nutrition to reduce food insecurity levels and its harmful health  consequences among maternal-child dyads, which will nurture their potential, and ultimately enable them to  thrive. This project is designed to inform how best multi-sectoral interventions (maternal-child health and food  insecurity interventions) can be integrated to promote transformation on the maternal-child health and nutrition  of historically marginalized communities.

PI_NAMEs: BUCCINI, GABRIELA  (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: 3 year old;Address;Adolescence;adverse outcome;Age;Birth;Birth Weight;care systems;Caring;Characteristics;Child;Child health care;Child Mortality;Child Nutrition;child services;Childhood;Collaborations;Color;Communities;community based participatory approach;community based participatory research;community intervention;Conceptions;Counseling;COVID-19;COVID-19 pandemic;Data;design;Development;Dietary Intervention;Education;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;Employment;Equity;ethnic disparity;Ethnic Origin;evidence base;Family;Food;food insecurity;food security;Generations;Goals;Health;Household;Housing;Human;Hybrids;Immunization;implementation evaluation;implementation framework;implementation outcomes;implementation science;improved;Inequity;Infant Health;Infant Mortality;innovation;insight;Intervention;Investments;Life;Life Cycle Stages;Link;Literature;Low income;marginalization;marginalized community;Maternal and Child Health;Maternal Mortality;maternal risk;Mental Health;Monitor;Neighborhoods;Nevada;nutrition;Outcome;Pathway interactions;Perinatal;Persons;Phase;Poverty;Pregnancy;Pregnant Women;prenatal;Prevalence;process improvement;Quasi-experiment;Race;Racial Equity;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recovery;Research;Resources;response;screening;service utilization;Services;Site;social health determinants;social interventions;Social Justice;socioeconomics;Solid;Southwestern United States;Structural Racism;success;System;therapy development

PROJECT_TITLE: Pathways to integrate maternal-child health and nutrition interventions to transform equity and human potential


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: Boston

ORG_DEPT: BIOLOGY

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: PROJECT NARRATIVE Alkylating agents in our environment cause DNA base lesions that can cause human disease and cancer. The overarching goal of this research program is to determine the molecular mechanisms of the human Shu complex and the RAD52 protein in lesion recognition and repair of stalled replication forks. I will employ cell biology, biochemical, and biophysical approaches to elucidate the non-canonical mechanism of repair while developing the training, research, and professional skills required for successful independent investigation.

PI_NAMEs: HENGEL, SARAH R (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Affinity;Alkylating Agents;Alkylation;analog;Area;Atomic Force Microscopy;base;Binding;Biochemical;Biological Assay;biophysical techniques;Biophysics;BRCA2 gene;Bypass;Cancer Center;Cells;Cellular biology;Complex;CRISPR/Cas technology;Data;Development;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA replication fork;DNA-Directed RNA Polymerase;drinking;drinking water;Electrophoretic Mobility Shift Assay;Environment;Equilibrium;ERCC6 gene;experimental study;Filament;Fluorescence Anisotropy;Fluorescence Microscopy;Fluorescence Resonance Energy Transfer;Genetic Transcription;Genomic Instability;Goals;Grant;Health;homologous recombination;Human;human disease;Hybrids;In Vitro;insight;Investigation;Knock-out;Label;Laboratories;laser tweezer;Lead;Lesion;Malignant Neoplasms;Mediating;member;Mentors;Molecular;mutant;novel;optic tweezer;Pathway interactions;Pesticides;Phase;Play;Process;programs;protein complex;Proteins;prototype;Publications;Rad51 recombinase;RAD52 gene;Radon;Recombinants;repaired;replication stress;Research;Resolution;Resources;response;RNA;Role;Series;single molecule;Single-Stranded DNA;Site;skills;Soil;Specificity;stoichiometry;Structure;Technical Expertise;Techniques;Testing;Time;Tobacco;Training;Transcription-Coupled Repair;Universities;Water Purification;Work;Writing;Yeasts

PROJECT_TITLE: Shu complex and RAD52 function in DNA damage recognition and subsequent repair

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities

ORG_CITY: SAN ANTONIO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Historically, the process of translating research findings into clinical care and public health initiatives has been notoriously slow. With the transition of the KL2 Program into the new K12 Program comes the opportunity to add a focus on translational science, the field of investigation focused on understanding the scientific and operational principles underlying each step of the translational process in order to catalyze translation. For the new funding period, we will recruit new K12 Scholars from an expanded pool; train mentors in current mentoring concepts; and incorporate new training in translational science – based on competencies we published for a translational researcher vs. a translational scientist – diversity, equity, inclusion, and accessibility, dissemination and implementation, and leadership.

PI_NAMEs: CAHILL, ALISON G;TSEVAT, JOEL  (contact)

PROGRAM_OFFICER_NAME: LEYVA, FRANCISCO

PROJECT_TERMS: Biomedical Research;career development;Competence;Disease;Dissemination and Implementation;Educational Curriculum;equity, diversity, and inclusion;evidence base;experience;Faculty;Female;Funding;Health Sciences;Home;innovation;Institution;Investigation;Leadership;member;Mentored Clinical Scientist Development Program;Mentors;North Carolina;Process;Program Development;programs;Publishing;Research Institute;Research Personnel;Research Project Grants;Scholars Program;Stream;Texas;Time;Training;Translation Process;Translational Research;translational scientist;Translations;Underrepresented Populations;Universities;Utah;virtual;Visit;visiting scholar;Woman

PROJECT_TITLE: CTSA K12 Program at The University of Texas Health Science Center at San Antonio


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Project Narrative Mechanisms underlying antibiotic resistance are extremely complex and have both genetic and non-genetic components. Here, I propose to develop a systematic framework utilizing a novel comprehensive genome-wide CRISPR-interference (CRISPRi) technology to interrogate the genetic and transcriptional determinants of antibiotic resistance in bacteria (with a focus on Escherichia coli and Staphylococcus aureus). The substantially improved sensitivity and versatility of the technology, along with computational tools and animal models, is expected to reveal rich insights guiding the rational design of new drugs and drug combinations.

PI_NAMEs: JIANG, WENYAN  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Aminoglycosides;Animal Model;Antibiotic Resistance;antibiotic tolerance;Antibiotics;antimicrobial;Bacteria;bacterial genetics;beta-Lactams;cellular targeting;Chemosensitization;Clinic;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Communities;Complex;Computer Analysis;computerized tools;cost;CRISPR interference;CRISPR library;CRISPR screen;CRISPR/Cas technology;Cytoprotection;Data;design;Development;Drug Combinations;drug development;Drug resistance;Engineering;Escherichia coli;Essential Genes;Event;experimental study;Expression Library;fitness;Foundations;Gene Expression;gene function;gene repression;Gene Targeting;Generations;Genes;Genetic;genetic architecture;Genetic study;Genetic Transcription;Genome;genome-wide;Genomic DNA;genomic locus;Genomics;Growth;Guide RNA;improved;In Vitro;in vivo;insight;Investigation;Knowledge;Libraries;loss of function;member;Methodology;Multi-Drug Resistance;Mutagenesis;Mutate;Mutation;new therapeutic target;non-genetic;novel;novel therapeutics;Oligonucleotides;Open Reading Frames;Organism;overexpression;Pathway Analysis;Pathway interactions;Pharmaceutical Preparations;Phenotype;Predisposition;Public Health;Quinolones;rational design;Recurrence;Resistance;resistance factors;resistance mechanism;resistant strain;RNA library;screening;Site;small molecule;Staphylococcus aureus;Surveys;synergism;System;Techniques;Technology;Time;trait;transcriptional reprogramming;Treatment Failure;Work

PROJECT_TITLE: New CRISPR tools for systematic interrogation of genetic and transcriptional determinants of antibiotic sensitivity in bacteria


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: Juno Beach

ORG_NAME: EMMUNE, INC

ORG_STATE: FL

PHR: PUBLIC HEALTH RELEVANCE: SARS-CoV-2 will be with human populations for years. The continued emergence of new variants is likely to reduce the efficacy of vaccines and allow continued spread through the population. Under this grant, we will develop improved SARS-CoV-2 vaccine antigens, which will focus the antibody response onto the targets that are shared among new variants of SARS-CoV-2

PI_NAMEs: ALPERT, MICHAEL DAVID (contact)

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: 2019-nCoV;ACE2;Address;Antibody Response;Antibody titer measurement;Antigens;B-Cell Antigen Receptor;Cells;Collaborations;Communities;COVID-19 vaccine;crosslink;Cytoplasmic Tail;Data;design;Engineering;Engraftment;Epitopes;exosome;experimental study;Face;Future;glycosylation;Goals;Grant;Human;Hydrophobicity;Immune response;immunogenic;immunogenicity;improved;In Vitro;industry partner;Length;Link;lipid nanoparticle;Lymphoid;Mann-Whitney U Test;Mesocricetus auratus;Messenger RNA;Moderna COVID-19 vaccine;mRNA delivery;mRNA lipid nano particle vaccine;Muscle;nanoparticle delivery;neutralizing antibody;Phase;Polysaccharides;Population;Positioning Attribute;Primates;Protein Subunits;Proteins;public health relevance;receptor binding;Research;Rodent;SARS-CoV-2 antigen;SARS-CoV-2 variant;Site;Tail;Testing;Transfection;Transmembrane Domain;Vaccine Antigen;vaccine development;vaccine efficacy;Vaccines;Variant;variants of concern;Viral

PROJECT_TITLE: SARS-CoV-2 vaccines based on RBDs with engineered glycosylation sites

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-P(11)]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Data Science;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative

ORG_CITY: ANN ARBOR

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: RELEVANCE TO PUBLIC HEALTH: NACDA promotes a better understanding of health and the promotion of health behaviors by collecting data and research information on the aging lifecourse. This information is reprocessed and then distributed from the NACDA website, providing a large and growing set of research tools to facilitate the study of disease, aging and overall health. This project will facilitate multidisciplinary research using longitudinal data focused on conative functioning and Alzheimer’s research.

PI_NAMEs: MARCOTTE, JOHN EDWIN (contact);MCNALLY, JAMES W

PROGRAM_OFFICER_NAME: KRUPENEVICH, REBECCA LYNN

PROJECT_TERMS: Acceleration;Address;Adoption;age acceleration;Aging;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Atlases;Basic Science;behavioral and social science;Behavioral Research;Bibliography;Categories;Clinical;Clinical Research;Cognition;Collection;Common Data Element;Communities;comorbidity;Computer software;computerized;COVID-19;COVID-19 complications;COVID-19 risk;Data;Data Analyses;Data Collection;Data Files;data integration;data interoperability;data management;data portal;data resource;Data Set;data sharing;digital data;Discipline;Disease;Educational workshop;Extensible Markup Language;Floods;Foundations;Geography;Gerontology;Goals;Growth;Health;Health behavior;Health Promotion;improved;Individual;Infrastructure;innovation;Interdisciplinary Study;Internet;interoperability;Life Cycle Stages;Light;Longitudinal Studies;Measures;Metadata;Modeling;National Archive;Neighborhoods;novel strategies;Outcome;outreach;Paper;Personal Computers;Phase;population health;pro-aging;Process;Public Health;Quality of life;relational database;repository;Reproducibility;Research;Research Infrastructure;Research Personnel;Resources;Risk;Science;Services;social health determinants;social media;social science research;Standardization;Structure;symposium;Technology;therapy development;tool;Training;Training and Education;United States National Institutes of Health;web site;webinar;Wisconsin;Work

PROJECT_TITLE: Creating an Interoperability Data Infrastructure for Research on the Aging Lifecourse


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Data Science;Health Services

ORG_DEPT: OTHER BASIC SCIENCES

PHR: Project Narrative Healthcare professionals often receive inadequate feedback about the quality of care they provide. We propose to build a software service that customizes feedback for healthcare professionals based on their requirements and preferences, and to evaluate the effect of using the service on care quality.

PI_NAMEs: LANDIS-LEWIS, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: YOON, SUNG SUG

PROJECT_TERMS: Adopted;Agreement;Anesthesia procedures;Benchmarking;Caring;Characteristics;Clinical;Clinical Decision Support Systems;clinical decision-making;clinical practice;Cluster Analysis;Cluster randomized trial;Cognitive;cognitive load;Communication;computable knowledge;Computer software;dashboard;Data;data to knowledge;digital;distraction;Drops;Electronic Mail;Electronics;Environment;evidence base;Fatigue;Feedback;Health;health care delivery;health care quality;Health Professional;Hospitals;improved;Individual;Informatics;information display;Infrastructure;interoperability;Intervention;K-Series Research Career Programs;Knowledge;knowledge base;Learning;Measurement;Measures;Methods;Michigan;Outcome;peer;Performance;personalized approach;preference;Principal Investigator;process evaluation;prototype;Provider;psychologic;Psychological Theory;Quality of Care;Reporting;Research;Sampling;Services;Surveys;System;Technology;Testing;theories;Time;United States National Library of Medicine;Universities;usability;user centered design;Vision;Visual;web services;Work

PROJECT_TITLE: A scalable service to improve health care quality through precision audit and feedback

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Dementia;Neurodegenerative;Neurosciences;Physical Activity;Prevention

ORG_CITY: KANSAS CITY

ORG_NAME: UNIVERSITY OF KANSAS MEDICAL CENTER

ORG_STATE: KS

PHR: PROJECT NARRATIVE We will examine the effects of a novel approach to increase adherence to exercise among mid-life adults. Results of this work are relevant to public health and Alzheimer's disease prevention because the study will focus on a scalable approach to promote adherence to exercise. Findings from this study will inform future intervention programs in to promote heart and brain health.

PI_NAMEs: MARTIN, LAURA E (contact)

PROGRAM_OFFICER_NAME: STOECKEL, LUKE

PROJECT_TERMS: acceptability and feasibility;Adherence;Adult;Affect;Affective;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease risk;Animal Model;Attention;Behavior;Behavior Therapy;Behavioral;Blood Vessels;Brain;brain health;Brain region;brief intervention;Cardiac health;Cardiovascular system;Cognitive;cognitive function;comparison intervention;Data;Decision Making;discounting;Environment;Exercise;exercise adherence;exercise intervention;Future;Genetic Risk;Goals;Guided imagery;Guidelines;Health;Health behavior;Health Benefit;Helping Behavior;Imagery;improved;indexing;Individual;innovation;Interval training;Intervention;intervention program;intervention refinement;Literature;middle age;Modeling;neural model;Neurobiology;novel;novel strategies;Outcome;Participant;Phase;Physical activity;physical conditioning;preference;Procedures;Property;Protocols documentation;Public Health;Randomized;Recommendation;Regulation;Research;response;Rewards;Risk Reduction;Stimulus;Support System;System;Testing;theories;Thinking;Time;Training;Treatment outcome;United States National Institutes of Health;Work

PROJECT_TITLE: Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging Among Mid-Life Adults


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: SPIKE NEURO LLC

PHR: Project Narrative While neuroscience research has made many advancements in the treatment of neurological diseases and disorders, the limitations of available research tools are creating roadblocks to the next wave of innovation. Spike Neuro is developing a new wireless neural recording and electrical stimulation system that will enable novel research studies focused on the treatment of neurological issues. This work will have the potential to inspire a renaissance of complex neuroscience studies spanning from small animals all the way to the clinical market.

PI_NAMEs: GERTH, REBECCA JEANNE (contact);MORIZIO, JAMES

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: Achievement;Address;analog;Animal Experimentation;Animal Model;Animals;Architecture;awake;base;battery life;battery size;Behavior;Bite;Clinical;clinical development;Clinical Research;clinical translation;commercialization;commercialization readiness;Communities;Complex;Computer software;Contracts;Data;data acquisition;Data Element;data exchange;Dedications;design;Development;Devices;digital;Disadvantaged;Dropout;Drops;Electric Stimulation;Electronics;Electrophysiology (science);Ensure;experimental study;flexibility;Future;Head;Hybrids;in vivo;Industry Standard;innovation;light weight;manufacture;Marketing;meter;Modeling;Morphologic artifacts;Motion;mouse model;Mus;Nervous System Disorder;neural;Neurologic;Neurosciences;Neurosciences Research;neurotransmission;Noise;nonhuman primate;novel;Output;Performance;Phase;Physiologic pulse;Polychlorinated Biphenyls;power consumption;Production;prototype;Radio;radio frequency;Rattus;Renaissance;Research;research and development;Research Design;Research Personnel;research study;Rest;Rodent;Sales;sensorimotor system;Series;Signal Transduction;Small Business Technology Transfer Research;Social Interaction;Stress;success;System;Technology;Testing;Time;tool;transmission process;Universities;Update;Validation;Weight;wireless;Wireless Technology;wireless transmission;Work

PROJECT_TITLE: Addressing the wireless power problem: A low-power hybrid radio for neuroscience experiments

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-C(10)B]


NIH_SPENDING_CATS: Aging;Wound Healing and Care

ORG_DEPT: SURGERY

ORG_NAME: BOSTON UNIVERSITY MEDICAL CAMPUS

PHR: This proposal will study how cellular senescence transiently arises during normal wound healing but fails to occur during aging where there is delayed wound healing. The senescent cells involved in cutaneous wound healing will be characterized with novel single-cell and spatial imaging techniques. The impact that aging has on this important wound response will be explored to determine if restoration of transient senescence can improve delayed healing of aging.

PI_NAMEs: ROH, DANIEL SAM (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Acute;acute wound;Affect;age group;age related;aged;Aging;angiogenesis;Anti-Inflammatory Agents;Apoptosis;Attenuated;attenuation;Award;Caring;CDKN2A gene;Cell Aging;Cell Communication;Cell Proliferation;cell type;Cells;chronic wound;Clinical Trials;Coculture Techniques;Collagen;Data;Data Analyses;data visualization;Deposition;Dermal;design;Dichloromethylene Diphosphonate;Economics;Excision;Extracellular Matrix;Fibroblasts;Gene Proteins;Genetic;Goals;Growth;Heterogeneity;Human;Imaging Techniques;Impaired healing;Impaired wound healing;Impairment;improved;life span;Macrophage;Mammals;Mentorship;middle age;Modification;Morbidity - disease rate;mortality;Multiple Wounds;Mus;necrotic tissue;novel;old mice;older adult;older patient;Operative Surgical Procedures;Organism;Patient risk;Patients;Phenotype;Physicians;Plastic Surgeon;Predisposition;Process;Production;Protein Biosynthesis;reconstitution;Regulation;Resistance;response;restoration;Role;Scientist;senescence;senescent cell;senolytics;Signal Transduction;single-cell RNA sequencing;skin wound;Skin wound healing;Sorting;Spatial Distribution;stressor;subcutaneous;targeted treatment;Testing;Therapeutic;Time;tissue injury;Tissues;Training;transcriptomics;Translational Research;United States;wound;wound care;wound closure;wound healing;Wound Infection;wound response

PROJECT_TITLE: Targeting Senescence to Improve Wound Healing in Aging


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Prevention;Women's Health Research

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative The results from this UO1 study will help to determine whether homologous recombination repair capacity in peripheral blood lymphocytes assessed in pre-diagnostic samples can predict the occurrence and modify the risk of breast cancer. We will also assess the correlation of HRR capacity between PBLs and matched tumor samples and develop a polygenic risk score for HRR.

PI_NAMEs: LIU, SONG ;ZHAO, HUA  (contact);ZHU, QIANQIAN

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: biobank;Biological Assay;BRCA1 gene;BRCA2 gene;Breast Cancer Early Detection;Breast Cancer Patient;Breast Cancer Risk Factor;breast tumorigenesis;burden of illness;cancer subtypes;Cancer-Predisposing Gene;Case/Control Studies;Cells;Characteristics;CHEK2 gene;cohort;Companions;cost;Data;Development;Diagnosis;Diagnostic;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Pathway;Etiology;exome sequencing;Frequencies;Genetic;Genetic Determinism;genome-wide;genomic data;Genotype;Goals;High Risk Woman;homologous recombination;homologous recombination deficiency;Immunophenotyping;Incidence;Individual;individualized prevention;innovation;insight;Intervention;Investigation;Life;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Mammary Gland Parenchyma;Mammary Neoplasms;Mammographic screening;Mammography;Measures;Modeling;Molecular;Mutation;Nested Case-Control Study;novel;PALB2 gene;Pathway interactions;Penetrance;Peripheral Blood Lymphocyte;Phenotype;polygenic risk score;population stratification;Population Study;predictive marker;Prevention strategy;prospective;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;recombinational repair;Resources;Risk;Risk Marker;risk prediction;risk stratification;Role;Sampling;screening;Testing;The Cancer Genome Atlas;Therapeutic;Tissues;tool;tumor;Tumor Tissue;tumorigenesis;Woman

PROJECT_TITLE: Homologous recombination repair capacity in peripheral blood lymphocytes as a breast cancer risk factor


NIH_SPENDING_CATS: Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Pediatric - AIDS

ORG_CITY: Stellenbosch

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: STELLENBOSCH UNIVERSITY

PHR: Project Narrative Remarkable success has been achieved to ensure an HIV-free start to life for over one million children born each year to women with HIV. The CHERISH study (Children HIV Exposed Uninfected Research to Inform Survival and Health) will establish and optimize an innovative system in the Western Cape Province of South Africa to measure HIV and antiretroviral drug exposure during pregnancy and associated infant and child survival, morbidity, growth and neurodevelopment to inform future interventions. This is of substantial public health importance in high HIV-burden countries, where up to 25% of all children are HIV exposed and uninfected, as well as low HIV burden countries where children who are HIV exposed and uninfected are not surviving and thriving as well as children who are HIV unexposed and uninfected.

PI_NAMEs: DAVIES, MARY-ANN ;TOMLINSON, MARK  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: Adolescent;Adult;adverse birth outcomes;Africa South of the Sahara;Age;antenatal;Anti-Retroviral Agents;antiretroviral therapy;Biostatistical Methods;Birth;Botswana;Breast Feeding;Cessation of life;Child;Child Health;Childhood;cohort;Cohort Studies;Collaborations;Communicable Diseases;Complex;Country;data centers;design;disparities in morbidity;Disparity;Drug Exposure;early childhood;Electronics;Ensure;Epidemic;Epidemiologic Methods;Epidemiology;Evaluation;Exposure to;feeding;follow-up;Funding;Future;Government;Growth;Health;health data;Health system;High Prevalence;HIV;HIV/AIDS;Home;Hospitalization;in utero;Income;Individual;infancy;Infant;Infection;innovation;Intervention;Investments;Life;Light;Link;Longitudinal cohort;Malnutrition;Measurement;Measures;Mediating;medication safety;Modality;Modeling;Modernization;Monitor;Morbidity - disease rate;Mothers;multiple data sources;National Institute of Child Health and Human Development;neurodevelopment;novel;Nutritional;Observational epidemiology;Outcome;Pathway interactions;Patients;pediatric human immunodeficiency virus;Pharmaceutical Preparations;Population;postnatal;Pregnancy;Premature Birth;prenatal exposure;Prevalence;Prevention;Province;Public Health;Research;Resources;Risk;Rural;Scientific Advances and Accomplishments;Sentinel;Site;socioeconomics;South Africa;Southern Africa;Statistical Methods;Subgroup;success;survival disparity;syndemic;System;Touch sensation;trend;United States;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: CHERISH (Children HIV Exposed Uninfected Research to Inform Survival and Health)


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Genetics;Human Genome;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PI_NAMEs: ALLEN, ANDREW S;CRAWFORD, GREGORY E;GERSBACH, CHARLES A.;KIBBE, WARREN A.;REDDY, TIMOTHY E (contact);SHASHI, VANDANA ;WRAY, GREGORY A.

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Area;Bioinformatics;Biological Assay;Biomedical Engineering;Case Study;Chromatin;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;combinatorial;Communication;Communities;Complex;Country;Data;data dissemination;Data Set;Dedications;Diagnostic;Discipline;Disease;Dryness;Education and Outreach;Electronics;Enzymes;epigenome;epigenomics;Evolution;experimental study;Foundations;functional genomics;Gene Expression;Gene Expression Regulation;Genes;Genetic;genetic association;Genetic Diseases;Genetic Structures;genetic variant;Genetic Variation;Genome;genome sciences;genome sequencing;genome-wide;Genomics;Goals;Health;high throughput technology;Human;Human Biology;human disease;Human Genetics;Human Genome;human genomics;Individual;innovation;Interdisciplinary Study;Knowledge;Measurement;Measures;Medical Genetics;Methodology;Methods;Modeling;multimodality;new technology;Newly Diagnosed;Outcome;outreach;Patients;Phenotype;Pilot Projects;Play;Population;Positioning Attribute;Prevalence;promoter;Rare Diseases;Regulatory Element;repaired;Request for Applications;Research;Research Personnel;Resources;Role;Schizophrenia;Scientist;Statistical Methods;statistics;success;synergism;Techniques;Technology;theories;Therapeutic;trait;Translating;Translational Research;translational scientist;Untranslated RNA;Variant;web portal;whole genome;Work

PROJECT_TITLE: The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of disease


ADMINISTERING_IC: GM

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Tuberculosis

ORG_CITY: CAMBRIDGE

ORG_DEPT: CHEMISTRY

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Extracellular polysaccharides play critical roles in bacteria. Our understanding of the enzymatic mechanisms facilitating polysaccharide biosynthesis and length control remain underdeveloped. The proposed work seeks to define the enzymatic mechanism by which Mycobacterium, a genus that includes serious human pathogens, controls the length of the galactan, an essential glycan integral to the cell wall structure within these organisms. The proposed research will inform future efforts in novel antibiotic design.

PI_NAMEs: CARTER, ALAN WYLDE (contact)

PROGRAM_OFFICER_NAME: STAMM, JOYCE CHIN-CHIN NG

PROJECT_TITLE: Enzymatic Mechanism of Polysaccharide Length Control by GlfT2


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Kidney Disease

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on evaluating the impact of systematic nephrology follow-up after in-hospital acute kidney injury, a common complication in patients admitted to the hospital that is associated with long-term adverse outcomes including cardiovascular disease, chronic kidney disease, and mortality. This study has the potential to improve intermediate outcomes such as rehospitalization and long-term clinical outcomes like chronic kidney disease progression. Thus, the proposed research is relevant to the part of the NIDDK’s mission that supports medical research on kidney diseases to improve people’s health and quality of life.

PI_NAMEs: PARIKH, CHIRAG R (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Address;Adult;adverse outcome;Algorithms;Angiotensin Receptor;Angiotensin-Converting Enzyme Inhibitors;Biological Markers;Biological Process;Blood;Blood Pressure;blood pressure control;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cardiovascular system;Caring;Cessation of life;Chronic Kidney Failure;Clinic;Clinical;clinical care;Clinical Investigator;comorbidity;Complication;Consent;Counseling;Creatinine;Dedications;Development;diabetes control;Disease Progression;Effectiveness;efficacy evaluation;electronic health record system;Eligibility Determination;Enzyme Inhibitor Drugs;Evaluation;Event;evidence base;experience;Fibrosis;follow-up;Funding;Glomerular Filtration Rate;Goals;Health;health assessment;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;improved;improved outcome;Incidence;Inflammation;Injury;innovation;insight;interdisciplinary approach;Intervention;Kidney;Kidney Diseases;Link;Managed Care;Measurement;Medical;Medical Research;medication safety;Mission;Modification;mortality;mortality risk;Multi-Institutional Clinical Trial;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;nephrotoxicity;Outcome;participant enrollment;Patient Admission;Patient Care;Patient Outcomes Assessments;Patient Recruitments;Patients;Perioperative;Persons;Pharmaceutical Preparations;Phenotype;pilot trial;precision medicine;primary outcome;prognostication;Public Health;Quality of life;Randomized;randomized trial;randomized, clinical trials;Recovery;recruit;Recurrence;Renal function;repaired;Research;research clinical testing;Research Personnel;research study;Risk;Risk Factors;satisfaction;screening;Serum;Site;standard of care;Survivors;Syndrome;Techniques;Telemedicine;Time;Translational Research;translational scientist;Trauma;treatment as usual;trend;trial comparing;Urine;Visit;Work

PROJECT_TITLE: Post-Discharge Nephrology Follow-up for Improved Outcomes


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: TALLAHASSEE

ORG_DEPT: NUTRITION

ORG_NAME: FLORIDA STATE UNIVERSITY

PHR: PROJECT NARRATIVE The well-known “use it or lose it” principle is that weight lifting builds muscle mass (hypertrophy) while unloading results in loss of mass (atrophy), but the molecular mechanisms regulating these changes are poorly understood for loading, and almost non-existent for unloading. We use heart cells in culture in models of loading and unloading to determine how the muscle proteins, CapZ and α-actinin, are chemically modified by ubiquitination or acetylation to regulate muscle mass. This project provides career training that may lead to new research lines for regulation in hypertrophic cardiomyopathies and sarcopenia.

PI_NAMEs: SOLIS OCAMPO, CHRISTOPHER  (contact)

PROGRAM_OFFICER_NAME: TJURMINA, OLGA A

PROJECT_TERMS: Acetylation;actin capping protein;Acute;Affect;alpha Actinin;aorta constriction;Atrophic;Biochemistry;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;career;career development;Cell Size;Cells;Cessation of life;Chemicals;Chicago;Data;Deacetylation;Dependovirus;Devices;Dominant-Negative Mutation;dosage;Dose;Environment;Enzymes;Equilibrium;extracellular;gel electrophoresis;Goals;HDAC3 gene;HDAC4 gene;Heart;heart cell;hemodynamics;Histone Deacetylase;Histone Deacetylase Inhibitor;Hormonal;human induced pluripotent stem cells;Hypertrophic Cardiomyopathy;Hypertrophy;Illinois;inhibitor;innovation;Intervention;Journals;Knowledge;Left;Lysine;Malignant Neoplasms;Mass Spectrum Analysis;mechanical load;mechanical stimulus;Mechanics;Mentors;Methods;Modeling;Modification;Molecular;mouse model;Mus;muscle form;Muscle Proteins;Myocardial;Myosin ATPase;Normal Cell;Oligonucleotides;Outcome;overexpression;Pathology;Pathway interactions;Periodicity;Phase;Physiological;Physiology;Post-Translational Protein Processing;Process;programs;protein degradation;Proteins;Proteomics;proteostasis;Publications;Rattus;Regulation;Research;Research Personnel;response;Rest;Sarcomeres;sarcopenia;Signal Pathway;Site;Small Interfering RNA;Stimulus;Structure;Testing;Training;Ubiquitin;Ubiquitination;Universities;Ventricular;Weight Lifting;Work

PROJECT_TITLE: Post-translational mechanisms of cardiac adaptation during unloading


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Oakland

ORG_NAME: KAISER FOUNDATION RESEARCH INSTITUTE

PHR: NARRATIVE There is a lack of culturally adapted, theory-based approaches to increasing physical activity for Latinx populations. Our proposed project will develop a community and researcher partnership to build and evaluate a culturally adapted, theory-based intervention for physical activity in Latinx adults over age 55.

PI_NAMEs: ROSENBERG, DORI E (contact);ZLATAR, ZVINKA ZOE

PROJECT_TERMS: Accelerometer;Acculturation;Adherence;Adult;Age;Alzheimer's disease related dementia;Alzheimer's disease risk;behavior change;brain health;cardiometabolism;Cerebrovascular Circulation;Cognition;Cognitive;cognitive function;Communities;community advisory board;comorbidity;Control Groups;coronavirus pandemic;County;Dementia;dementia risk;design;Exercise;exercise intervention;Feedback;fitbit;Goals;Growth;Guidelines;Habits;Health;Health Promotion;high risk;Hour;human old age (65+);Hypertension;Impaired cognition;improved;Individual;innovation;Intervention;intervention effect;Latina;Latino;Latinx;Latinx population;Measurement;Mediation;meetings;middle age;moderate-to-vigorous physical activity;Non-Insulin-Dependent Diabetes Mellitus;Obesity;older adult;Outcome;Participant;Persons;Phase;Physical activity;pilot test;Population;prevent;primary outcome;psychosocial;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Research;Research Personnel;Risk;Risk Factors;Risk Reduction;secondary outcome;sedentary;sedentary lifestyle;Self Efficacy;sex;social;Social support;structural determinants;Target Populations;Testing;theories;Theory of Change;Time;Translations;treatment arm;white matter;Work

PROJECT_TITLE: De Pié y a Movernos Study: Promoting physical activity in older Latinx adults


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Bioengineering;Biomedical Imaging;Biotechnology;Brain Disorders;Dementia;Epilepsy;Genetics;Neurodegenerative;Neurosciences;Parkinson's Disease;Precision Medicine

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PI_NAMEs: LEE, JIN HYUNG  (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: Address;Anatomy;Animals;Behavior;Biological;biophysical model;Brain;Brain region;Cell model;cell type;Cells;Clinical Trials;clinically relevant;Computer Models;Data;Deep Brain Stimulation;Dementia;design;Development;Diffusion Magnetic Resonance Imaging;Enhancers;Epilepsy;Evolution;Experimental Models;experimental study;France;Frequencies;Functional Magnetic Resonance Imaging;Gene Expression;Generations;Genetic;genetic manipulation;Goals;Human;improved;in silico;in vivo;Individual;individual patient;insight;Instruction;International;Interruption;Israel;Magnetic Resonance Imaging;Memory;Mental Depression;Mental disorders;Modeling;Motor;motor behavior;mouse model;Movement Disorders;Mus;Nervous System Disorder;optogenetics;Oxidopamine;Parkinson Disease;Pathology;personalized approach;predictive modeling;Process;Research Proposals;Resolution;Rest;Scanning;Seizures;Specificity;Speed;Statistical Models;Stimulus;success;symptom treatment;Technology;Testing;therapy outcome;Time;Transgenic Animals;Transgenic Mice;Translations;Treatment outcome;Validation;virtual

PROJECT_TITLE: CRCNS: US-France-Israel Research Proposal: A personalized approach to brain stimulation


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: ATHENS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: Project Narrative: Colorectal cancer (CRC) remains one of the leading cancer types and affects the health of men and women in the United States and worldwide. New immune checkpoint inhibitors (ICIs) have ushered in a new era of immunotherapy and become important treatment options for a variety of solid tumors, but the majority of CRC patients (>85%) respond poorly to ICIs. In this project, we intend to investigate the potential utility of sulindac in enhancing CRC to ICI immunotherapy.

PI_NAMEs: XI, YAGUANG  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Address;advanced disease;Affect;Animal Model;anti-CTLA4;anti-PD-1;anti-PD-L1;anti-PD-L1 antibodies;anti-PD-L1 therapy;Antibodies;Binding;Biological Markers;Body Weight decreased;Cancer Model;cancer type;CD8B1 gene;cell transformation;Cells;checkpoint therapy;Chemopreventive Agent;Chromosomal Instability;Circulation;Clinic;Clinical;Clinical Research;clinically relevant;colon cancer patients;Colorectal Cancer;colorectal cancer metastasis;colorectal cancer progression;colorectal cancer treatment;Combined Modality Therapy;CT26;Data;Development;DNA;DNA Repair;DNA Sequence;Dose;efficacy evaluation;efficacy study;exosome;experimental study;FDA approved;Gene Expression;Genetic Transcription;glycosylation;Growth;Human;Immune checkpoint inhibitor;Immunotherapy;implantation;improved;in vivo;innovation;interest;ipilimumab;male health;Malignant - descriptor;MC38;metastatic colorectal;MicroRNAs;Microsatellite Instability;Microsatellite Repeats;Mismatch Repair;Mismatch Repair Deficiency;Modeling;Molecular;mouse model;Mus;Mutation;Nivolumab;Non-Steroidal Anti-Inflammatory Agents;patient derived xenograft model;Patients;pembrolizumab;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Phase II Clinical Trials;posttranscriptional;Production;programmed cell death ligand 1;Publications;recruit;Reporting;Research;response;Safety;Signal Transduction;Solid Neoplasm;success;Sulindac;Survival Rate;Tandem Repeat Sequences;Testing;Therapeutic;Toxic effect;transcription factor;Translating;tumor;Tumor Tissue;Tumor Volume;tumor xenograft;Tumor-Infiltrating Lymphocytes;United States;Woman

PROJECT_TITLE: Sulindac sensitizes colorectal cancer to anti-PD-L1 therapy


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Genetics;Nanotechnology;Neurosciences;Regenerative Medicine;Wound Healing and Care

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Project Narrative This mentored quantitative research career development award aims to seed the career of a Purdue trained engineer and nanoscientist to develop a biomedical research career. The scientific focus is on tissue nanotransfection (TNT), an electromotive gene transfer technology that delivers plasmids, RNA and oligonucleotides to the live tissue in vivo. TNT has been reported as a novel technology in regenerative medicine and wound healing.

PI_NAMEs: XUAN, YI  (contact)

PROGRAM_OFFICER_NAME: PAUL, MOUSHUMI

PROJECT_TERMS: Acceleration;Actins;Address;Adopted;Adult;Animal Model;Biological;Biology;biomarker discovery;Biomedical Research;Blood Vessels;career;Cells;Characteristics;Clinical;Clinical Trials;clinically significant;Cytoskeletal Modeling;Dedications;design;Devices;Diabetic mouse;diabetic ulcer;diabetic wound healing;Disease;Drug Delivery Systems;efficacy testing;electric field;Electrophysiology (science);Encapsulated;engineered exosomes;Engineering;Ensure;exosome;Gene Transfer;Generations;Genomics;Goals;Health;Human;Immune;improved;In Vitro;in vivo;intercellular communication;interest;K-Series Research Career Programs;Label;Laboratories;Learning;Lipids;Mediator;Medicine;Mentors;Messenger RNA;Methods;MicroRNAs;Microtubules;Modification;Multivesicular Body;Mus;nano;nanocarrier;nanomedicine;nanoscience;Nanotechnology;nanotransfection;neurogenesis;Neurons;new technology;Nucleic Acids;Oligonucleotides;paracrine;Plasmids;pre-clinical;Preclinical Testing;Procedures;Proteins;rab GTP-Binding Proteins;recruit;Regenerative Medicine;Reporting;Research;Research Proposals;research study;Risk;RNA;Role;Science;Signal Transduction;skills;Skin;skin wound;Skin wound healing;Structure;Technology;technology platform;Technology Transfer;Testing;Therapeutic;tissue regeneration;Tissues;Training;United States National Institutes of Health;vasculogenesis;Work;wound closure;wound healing

PROJECT_TITLE: Nanofabricated Devices and Nanomedicine Approaches for Wound Healing

STUDY_SECTION: GDD

STUDY_SECTION_NAME: Gene and Drug Delivery Systems Study Section[GDD]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: CLEVELAND

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The T35 Case Medical Student Summer Research Program (MSSRP) at Case Western Reserve University School of Medicine (CWRU SoM) is designed to attract medical students to careers as physician-scientists in the mission areas of the NIDDK by providing students with a short-term research experience during the summer between their first and second year of medical school under the mentorship of highly-qualified and motivated faculty mentors. The academic institutional environment at CWRU SoM is ideal to support this program.

PI_NAMEs: COMINELLI, FABIO  (contact);PIZARRO, THERESA TORRES

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Advisory Committees;Area;Basic Science;career development;Clinic;Clinical Research;Collaborations;Cost Sharing;Development;Diabetes Mellitus;Digestive System Disorders;Direct Costs;Educational Curriculum;Environment;Evaluation;faculty mentor;Funding;Goals;Group Meetings;Infection;Inflammation;Infrastructure;innovation;Institution;interest;Investigation;Kidney Diseases;lectures;Liver diseases;Medical center;Medical Education;medical schools;Medical Students;Mentors;Metabolic Diseases;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Physicians;Process;Productivity;Program Evaluation;programs;Qualifying;Request for Applications;Research;Research Personnel;Research Project Grants;Resources;Scientist;Strategic Planning;Students;summer research;Training;Training Programs;tumorigenesis;United States National Institutes of Health;University Hospitals;Writing

PROJECT_TITLE: The Case Medical Student Summer Research Program (MSSRP)


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Chronic Pain;Clinical Research;Dental, Oral, and Craniofacial Disease;Immunotherapy;Neurosciences;Pain Research;Rare Diseases

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE: Nociceptors are specialized sensory neurons which detect noxious stimuli. These neurons serve a vital protective role in organisms at homeostasis, but pathologies leading to hyperactivation of nociceptors leads to debilitating pain. This project will explore how the innate immune sensor STING regulates pain in steady-state conditions and in head and neck cancer. This project will substantiate STING pathway agonists as a therapeutic strategy for cancer pain through bidirectional neuro-immune signaling. Completion of this project will accelerate the translation of STING agonists as cancer pain therapy.

PI_NAMEs: DONNELLY, CHRISTOPHER RYAN (contact)

PROGRAM_OFFICER_NAME: GHIM, MELISSA M

PROJECT_TERMS: Absence of pain sensation;Acceleration;Afferent Neurons;Agonist;Analgesics;antinociception;Behavioral;behavioral phenotyping;Biochemical;Bioinformatics;Biological Response Modifiers;cancer immunotherapy;cancer pain;Cancer Patient;cancer subtypes;cancer therapy;cancer type;cell type;Cells;Clinical Trials;combinatorial;Communication;cytokine;Data;debilitating pain;Deglutition;Dendritic Cells;Disease;Eating;Electrophysiology (science);experience;experimental study;feeding;Functional impairment;Genetic;Genetic Transcription;Goals;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Health;Homeostasis;Human;Immune;Immunooncology;Immunotherapeutic agent;Immunotherapy;Interferon Type I;Interferons;Knowledge;Malignant Neoplasms;Mediating;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Neuroimmune;neuronal cell body;Neurons;Nociception;Nociceptors;nonhuman primate;novel;novel strategies;novel therapeutics;Oral cavity;Organism;Oropharyngeal;Pain;pain inhibition;Pain management;pain model;pain relief;Pathologic;Pathology;Pathway interactions;Patients;Peripheral;Physiological;Property;Publications;Quality of life;Reporting;Research Personnel;Role;sensor;Shapes;Signal Transduction;small molecule;standard care;standard of care;Stimulus;STING agonists;success;Techniques;Testing;Therapeutic;translational potential;Translations;TRPV1 gene;tumor;Tumor Immunity;tumor-immune system interactions

PROJECT_TITLE: Neuro-immune modulation of pain in health and disease


ORG_CITY: NEW HAVEN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative The import of the viral capsid into the nucleus is an essential step in human immunodeficiency virus (HIV) infection of a host cell, yet little is known about this process at the molecular level. We will leverage innovative in vitro platforms and DNA nanotechnology to provide unprecedented molecular insight into the nuclear transport of HIV. We expect that this project will provide new mechanistic insight into HIV-1 nuclear entry and inspire innovations in antiretroviral therapy.

PI_NAMEs: LIN, CHENXIANG ;XIONG, YONG  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Affinity;antiretroviral therapy;Architecture;base;Binding;Biochemical;Biochemistry;Biological Assay;Biological Models;Capsid;Capsid Proteins;Cell Nucleus;Cells;Communities;Complement;Complex;Cryoelectron Microscopy;Cytoplasm;density;design;Diameter;Dimensions;Disease;DNA;Docking;Environment;experimental study;Face;Foundations;Gatekeeping;Genetic;genetic approach;Genome;Geometry;global health;Goals;HIV;HIV Infections;HIV-1;In Vitro;Individual;inhibitor;innovation;insight;Integration Host Factors;Invaded;Libraries;live cell imaging;Molecular;Mutagenesis;nanopore;Nanotechnology;novel;Nuclear;Nuclear Import;Nuclear Pore;Nuclear Pore Complex;Nuclear Pore Complex Proteins;Nuclear Proteins;nucleocytoplasmic transport;NUP214 gene;pathogen;Pattern;Pattern Recognition;Pore Proteins;Positioning Attribute;Process;protein structure;Proteins;Recombinants;Research;Research Personnel;Research Project Grants;Rest;Series;Specificity;structural biology;Structure;success;Surface;System;Techniques;Testing;therapeutic development;three dimensional structure;tool;Validation;Viral;Viral Genes;Virus;Virus Diseases;Virus Replication;Work;X-Ray Crystallography

PROJECT_TITLE: A multiscale approach for elucidating nuclear entry mechanisms of HIV-1 capsid

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Mental Health;Mental Illness;Neurosciences;Pediatric;Prevention

ORG_DEPT: PSYCHIATRY

PHR: PROJECT NARRATIVE This project uses innovative laboratory- and smartphone-based approaches to map out trajectories of irritability over a two-year period in youth ages 8–13 years and identify factors related to the brain, physiology, behavior, social experience, and family/environment that predict and explain why some children remain highly irritable over time. Results will provide insights into the risk and protective factors of chronic irritability in youth. This knowledge will help advance efforts toward development of evidence-based preventions and interventions for many pediatric disorders for which irritability is a prominent symptom.

PI_NAMEs: TSENG, WAN-LING  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adolescence;adverse outcome;Affect;Age;Anger;Anxiety;Behavior;Brain;Cellular Phone;Child;Child Psychiatry;Childhood;Chronic;Conflict (Psychology);Data;Development;Disease;Ecological momentary assessment;Environment;Environmental Risk Factor;Etiology;evidence base;Evidence based treatment;experience;Family;Frustration;Functional Magnetic Resonance Imaging;Goals;Growth;Heart Rate;imaging study;Impairment;informant;innovation;insight;Intervention;Knowledge;Laboratories;Link;Machine Learning;Maps;Measures;Mediating;Mental Depression;Methods;Modeling;neural;novel;Parents;peer;person centered;Persons;Physiology;Prevention;protective factors;Psychopathology;Reporting;Risk;Risk Factors;Role;Sampling;Schools;Services;social;suicidal;Suspensions;Symptoms;Time;time use;Youth

PROJECT_TITLE: Multi-level mechanisms and predictors of irritability: An innovative approach bridging laboratory and real-world measures

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-L (70)]


NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative  Most cancer patients will undergo radiation therapy at some point in their disease course, a treatment that frequently causes collateral injury to healthy tissue, leading to severe complications or even treatment discon- tinuation. Current methods of preventing this injury are wrought with challenges: 1) the inability to sustain radio- protection and maintain tumor cytotoxic effects simultaneously, and 2) side effects. In this proposal, we aim to develop a novel RNA strategy that delivers self-amplifying-RNAs coding for extremophile properties to tissues at risk for radiation-induced normal tissue injury.

PI_NAMEs: BYRNE, JAMES DONALD (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Cancer Patient;Cells;Clinical;Code;cytotoxic;Disease;Ensure;Hypotension;Infection;Inferior;Injury;innovation;Methods;Morbidity - disease rate;Normal tissue morphology;novel;nucleic acid delivery;Nucleic Acids;oral mucositis;Patient-Focused Outcomes;prevent;Process;Proctitis;Property;Proteins;Quality of life;Radiation;Radiation Protection;radiation risk;Radiation therapy;radiation-induced injury;radioprotected;RNA;RNA amplification;side effect;targeted delivery;Techniques;Technology;tissue injury;Tissues;tumor;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-A (70)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE  The mammalian brain is composed of trillions of diverse types of synaptic connections that form precise and stereotyped synaptic circuits essential for brain functions. Despite the importance of synaptic circuit formation, refinement, and maintenance for virtually all behaviors and neurological disorders, the mechanisms underlying these processes remain unknown. Our studies are directed at illuminating how the mammalian central nervous system is wired together into circuits that enable our perception and experience of the world.

PI_NAMEs: SANDO, RICHARD CHESLOCK (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Adhesions;alpha-latrotoxin receptor;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior Disorders;Behavioral;behavioral response;Biological;Biological Process;Brain;Cell Adhesion;Cell Adhesion Molecules;Central Nervous System;Code;Development;Disease;Drug Targeting;Exhibits;experience;FDA approved;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;genetic approach;Genome engineering;Hippocampus;Human;imaging approach;in vivo;information processing;insight;Life;Link;Logic;Maintenance;Malignant Neoplasms;Mediating;member;Molecular;Monitor;mouse model;multidisciplinary;nanoscale;Nervous System;nervous system development;Nervous System Disorder;neural circuit;Neurons;Neurosciences;novel;Patients;Perception;Process;Signal Transduction;Specificity;Stereotyping;Synapses;synaptogenesis;therapeutically effective;virtual;Visualization

PROJECT_TITLE: Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: GAINESVILLE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE This proposed research seeks to develop a new generation of IMDs, termed "wireless microdevices". This will enable the deployment of multiple battery-free, injectable microchips anywhere in the body. These versatile microdevices will integrate energy harvesting, telecommunication functions, and capabilities tailored to specific applications.

PI_NAMEs: KHALIFA, ADAM  (contact)

PROJECT_TITLE: Minimally Invasive and Versatile Next-Generation Implantable Medical Devices: A Leap Towards Precision Therapies and Medicine


NIH_SPENDING_CATS: Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

ORG_DEPT: PATHOLOGY

PHR: Project Narrative Cell-to-cell differences in gene expression (heterogeneity) underlies stem cell function and cancer, though we lack understanding of its origins. Here we propose to identify fundamental mechanisms by which cell systems encode heterogeneity using genomics and systems biology approaches. By identifying the principles by which cells encode gene expression heterogeneity we can unlock new therapeutic strategies to engage stem cells in regenerative medicine and to overcome treatment failure in cancer.

PI_NAMEs: GARG, SALIL  (contact)

PROGRAM_OFFICER_NAME: PAZIN, MICHAEL J

PROJECT_TERMS: Adult;Behavior;Biological Assay;Biological Models;Cell Physiology;cell type;Cells;Development;Embryo;embryonic stem cell;Enhancers;Epigenetic Process;Exhibits;Future;Gene Expression;Gene Expression Process;gene product;Generations;Genes;Genetic Template;Genetic Transcription;Genome;Genomics;Goals;Health;Heritability;Heterogeneity;Homeostasis;Human;Immune;Malignant Neoplasms;Mammals;Memory;Mutation;Noise;non-genetic;novel therapeutic intervention;Nucleic Acid Regulatory Sequences;Population;Production;programs;Regenerative Medicine;Regulation;Regulator Genes;Reproducibility;Signal Transduction;stem cell function;stem cells;Stochastic Processes;System;Systems Biology;therapeutic target;transcription factor;transmission process;Treatment Failure;tumor heterogeneity;Variant

PROJECT_TITLE: Genomic encoding of heterogeneity


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: Jupiter

ORG_NAME: MAX PLANCK FLORIDA CORPORATION

PHR: Project Narrative We aim to discover novel mitochondrial mechanisms driving learning and memory. This research will significantly impact human health as mitochondria are hotspots of dysregulation in neurodegenerative, neuropsychiatric, and neurodevelopmental diseases. Novel insights from our findings will also help develop future diagnostic and therapeutic strategies for many conditions associated with mitochondrial impairment, such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis.

PI_NAMEs: RANGARAJU, VIDHYA  (contact)

PROJECT_TERMS: Acute;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;ATP Synthesis Pathway;Automobile Driving;Behavior;Behavioral Assay;Biological Process;Brain;Calcium;Cells;Cognitive;coping;CRISPR screen;Data;Dendrites;Diagnostic;Diffusion;Energy consumption;Energy Supply;Energy-Generating Resources;flexibility;Future;Goals;Health;Hour;Human;Impaired cognition;Impairment;in vivo;Individual;innovation;insight;Interruption;Ions;Knowledge;Learning;Learning Disorders;Light;Link;Logistics;Maintenance;Measures;Memory;Memory Disorders;Memory impairment;Metabolic;Methods;Mitochondria;mitochondrial dysfunction;Motor;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal cell body;Neurons;neuropsychiatric disorder;novel;Organ;Parkinson Disease;Process;Production;Proteins;Proteomics;Regulation;Research;Stimulus;Synapses;Synaptic plasticity;temporal measurement;Therapeutic;Time

PROJECT_TITLE: Identifying Mitochondrial Mechanisms Driving Learning and Memory


NIH_SPENDING_CATS: Genetics

PHR: Narrative Modern human expanded worldwide and settled in different environments that subjected them to selective pressure, driving genetic adaptations to varied local conditions. We are using ancient DNA to contextualize the emergence of genomic adaptive variants that have undergone selection in both now-extinct archaic and modern human populations in East Asia and understand how these populations adapted to diverse environmental pressure, including climate, diets, and infectious diseases. This project aims to enhance our understanding of the evolution of recent human phenotypes by defining the genetic basis of human adaptive traits.

PI_NAMEs: MASSILANI, DIYENDO  (contact)

PROGRAM_OFFICER_NAME: ADKINS, RONALD

PROJECT_TITLE: Tracing the evolutionary history of human adaptive traits through ancient DNA


NIH_SPENDING_CATS: Cancer

ORG_CITY: DALLAS

ORG_DEPT: PEDIATRICS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Oxidative stress is the major metabolic barrier for cancer metastasis, but little is known about the adaptive mechanisms necessary for metastasizing cancer cells to survive and colonize distant organs. We will use a comprehensive and innovative optogenetic and subcellular redox modification platform in cell lines and mouse models to understand how individual organelles allow cancer cells to survive oxidative stress. The data generated from this proposal will provide fundamental insights into redox biology that may be applicable to a broad range of diseases impacted by redox alterations.

PI_NAMEs: GARCIA BERMUDEZ, JAVIER  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Address;Antioxidants;Biology;cancer cell;Cancer Model;Cancer Patient;Cause of Death;Cell Line;Cells;Coupled;Data;Disease;Disseminated Malignant Neoplasm;Distant;Exposure to;extracellular;gene therapy;Genetic;Hand;improved;In Vitro;in vivo;Individual;innovation;insight;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Metabolic;metabolomics;Modification;mouse model;Mus;Neoplasm Metastasis;novel therapeutic intervention;optogenetics;Organ;Organelles;Oxidation-Reduction;Oxidative Stress;Pathway interactions;Patient-Focused Outcomes;Primary Neoplasm;Process;Proteins;Reactive Oxygen Species;Resolution;Role;Shapes;spatiotemporal;Techniques;Technology;Testing;Tissues;tool;tumor;Work

PROJECT_TITLE: High-resolution approaches to dissect the role of subcellular redox circuits in vivo