NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Post-Traumatic Stress Disorder (PTSD);Rehabilitation;Substance Misuse

ORG_CITY: RESEARCH TRIANGLE PARK

ORG_NAME: RESEARCH TRIANGLE INSTITUTE

ORG_STATE: NC

PHR: Co-occurring alcohol use disorder and posttraumatic stress disorder (AUD/PTSD) is prevalent among U.S. veterans, and existing AUD/PTSD treatments are associated with high patient dropout. We will conduct a pilot randomized controlled trial in a sample of veterans with AUD/PTSD to test the feasibility, acceptability, and preliminary effects of Behavioral Activation, an integrated and recovery-oriented treatment, on subjective (clinical) and objective (geospatial) outcomes. This project will improve the lives of the nearly two million U.S. veterans with AUD/PTSD by providing them with an effective and acceptable treatment option for their health and well-being.

PI_NAMEs: BLAKEY, SHANNON MICHELLE (contact);ELBOGEN, ERIC B.

PROGRAM_OFFICER_NAME: ROACH, DEIDRA

PROJECT_TERMS: acceptability and feasibility;active comparator;Adult;Aftercare;alcohol abuse therapy;Alcohol consumption;alcohol free;alcohol measurement;alcohol response;alcohol use disorder;Alcohols;Anxiety;Assessment tool;avoidance behavior;Behavior;behavior test;Behavior Therapy;Behavioral;Benchmarking;Caring;Client satisfaction;Clinical;Clinical assessments;clinical practice;Clinical Trials;clinically significant;Collaborations;Communities;Computer software;Coupled;Crowding;Data;Daughter;Dimensions;Disease;drinking;Dropout;Drug usage;Drug Use Disorder;dual diagnosis;efficacy trial;Emotions;Evaluation;Event;feasibility testing;Future;Global Positioning System;Goals;Health;Health Promotion;high risk;Home;improved;Individual;innovation;interest;Intervention;longitudinal analysis;Manuals;Maps;Measurement;Measures;Mediator;Memory;Mental Depression;Methods;military veteran;Movement;National Institute on Alcohol Abuse and Alcoholism;Nightmare;novel;novel strategies;Outcome;Pamphlets;Participant;Patient Dropouts;patient handout;Patients;Personal Satisfaction;Persons;pilot test;portability;Post-Traumatic Stress Disorders;power analysis;Procedures;Process;Protocols documentation;psychiatric comorbidity;psychosocial;Randomized;Randomized, Controlled Trials;Recovery;Recovery of Function;recruit;reduce symptoms;rehabilitation research;relapse prevention;Research;response;Rewards;Sampling;Secure;severe mental illness;Severities;social;social determinants;statistics;suicidal risk;sustained recovery;Symptoms;Techniques;Technology;Testing;Trauma;treatment effect;treatment response;Veterans;Veterans Health Administration;Vocation;Walking;Well in self;Work

PROJECT_TITLE: Adapting and Piloting Behavioral Activation for Veterans with Co-Occurring AUD and Posttraumatic Stress Disorder

STUDY_SECTION_NAME: Clinical, Treatment and Health Services Research Study Section[AA-3]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Arthritis;Chronic Pain;Clinical Research;Kidney Disease;Pain Research;Prevention

ORG_CITY: SAN FRANCISCO

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: NORTHERN CALIFORNIA INSTITUTE/RES/EDU

ORG_STATE: CA

PHR: PROJECT SUMMARY Non-steroidal anti-inflammatory drugs (NSAIDs) are essential medications for the treatment of chronic pain, but their threat of kidney toxicity limits their availability to many patients. Currently, there is no monitoring strategy for kidney safety other than using the serum creatinine, which is neither sensitive nor specific for detecting actual kidney injury from NSAIDs. Our goal in this proposal is to develop an NSAID Kidney Monitoring Panel that would allow the safe use of NSAIDs for patients in chronic pain who are also at high risk for kidney disease.

PI_NAMEs: ESTRELLA, MICHELLE M (contact);SHLIPAK, MICHAEL G

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Absence of pain sensation;Adult;Adverse effects;Analgesics;Ankylosing spondylitis;Benign;Biological Markers;Blood;Chronic;Chronic Kidney Failure;Chronic Kidney Insufficiency;chronic pain;chronic pain management;Clinical;cohort;Collaborations;comorbidity;Creatinine;Development;diagnostic panel;Dimensions;disorder risk;Dose;drug action;Drug Exposure;Drug toxicity;Drug usage;Early Diagnosis;effective therapy;Elderly;Essential Drugs;evidence base;experience;Fibrosis;follow-up;Fright;Fumarates;Future;Generations;Glomerular Filtration Rate;Goals;Health;high risk;high risk population;HIV Infections;Hypertension;improved;Incidence;Inflammation;Injury;Injury to Kidney;insight;Kidney;Kidney Diseases;Learning;Measures;Monitor;Muscle;nephrotoxicity;Non-Steroidal Anti-Inflammatory Agents;novel;older adult;Opioid;opioid epidemic;Outcome;Pain;Pain management;Participant;Patients;Pattern;Persons;Pharmaceutical Preparations;Population;Prevalence;prognostication;Proteins;renal artery;renal damage;Renal function;Renal tubule structure;Research;Risk;Risk Factors;risk mitigation;Role;Safety;Serum;Severities;Site;Specificity;Spondylarthritis;Tenofovir;Time;tool;Toxic effect;treatment choice;Tubular formation;United States;Urine;vasoconstriction;Work

PROJECT_TITLE: Non-SteroidAl Impact on Kidney Disease Study (NSAIDS)

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Cancer;Clinical Research;Disability Research;Prevention;Rehabilitation

ORG_CITY: PORTLAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE With a doubling in the number of older cancer survivors in just a few decades preventing falls, dysfunction and disability from systemic cancer treatment is an urgent public health issue. Our phased R21/R33 study will advance an infrastructure advancing the use of digital biomarkers and related technologies for research on functional aging and survivorship in cancer.

PI_NAMEs: KAYE, JEFFREY A;WINTERS-STONE, KERRI M (contact)

PROGRAM_OFFICER_NAME: GUIDA, JENNIFER LYN

PROJECT_TERMS: Acceleration;Accelerometer;Address;Age;age acceleration;Age Years;Aging;aging process;anti-cancer research;behavioral health;Biology;Biometry;cancer care;Cancer Science;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Characteristics;Clinical;Clinical assessments;Cognition;Communities;community advisory board;Complex;daily functioning;Data;Data Analytics;Data Collection;data integration;Dedications;Dependence;design;Diagnosis;digital assessment;Digital biomarker;digital technology;digital tool;Dimensions;disability;Disease;early onset;Elderly;Electronics;end of life;Ensure;Fall prevention;falls;Family;frailty;functional decline;functional disability;Functional disorder;functional loss;Funding;Geroscience;Health;Healthcare Systems;Hematology;Home;human old age (65+);Impaired cognition;Impairment;Infrastructure;infrastructure development;interdisciplinary collaboration;Knowledge;Learning;Life;Longitudinal Studies;Malignant Neoplasms;Measures;Medical;Methodology;Methods;Monitor;Moods;Morbidity - disease rate;multidimensional data;multiple chronic conditions;normal aging;novel;older adult;older patient;Oncology;pathological aging;Patient Outcomes Assessments;Patients;Perception;Personal Satisfaction;Persons;Phase;Phased Innovation Awards;Productivity;protective factors;Protocols documentation;Public Health;Quality of life;remote assessment;remote sensing;Reporting;Research;Research Infrastructure;Research Personnel;response;Risk;Risk Factors;scale up;sensor;side effect;Signal Transduction;Sleep disturbances;Socialization;Speed;Spouses;Surveys;Survivors;survivorship;Symptoms;Technology;technology platform;Time;Treatment-Related Cancer;trial readiness;United States National Institutes of Health;wearable device;Work

PROJECT_TITLE: The Pacific Aging and Cancer Studies (PACS): An Infrastructure Advancing the Use of Digital Biomarkers and Related Technologies for Research on Functional Aging and Survivorship in Cancer

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: AA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biomedical Imaging;Brain Disorders;Clinical Research;Mental Health;Neurosciences;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PI_NAMEs: KRYSTAL, JOHN H. (contact)

PROJECT_TERMS: addiction;Address;Agonist;Alcohol consumption;alcohol research;alcohol response;alcohol use disorder;Alcoholic beverage heavy drinker;Alcoholism;Alcohols;Atlases;Benzoates;biomedical imaging;Biometry;Body mass index;Brain;Clinical;Clinical Research;Collaborations;computational neuroscience;Consultations;Data;density;Diagnostic Imaging;Doctor of Medicine;Doctor of Philosophy;Ethanol;Faculty;Family history of;Feedback;Fingerprint;Foundations;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Funding;Genetic;Human;in vivo;Individual;inhibitor;innovation;Intravenous;Lead;Link;Machine Learning;Magnetoencephalography;Maps;member;Metabolism;metabotropic glutamate receptor 2;Methodology;Molecular;N-Methylaspartate;National Institute on Alcohol Abuse and Alcoholism;neurobehavioral;Neurology;Neurosciences;novel;novel therapeutics;Physics;Pilot Projects;polygenic risk score;Positron-Emission Tomography;preclinical study;Process;Protocols documentation;Psychiatry;radiological imaging;Radiology Specialty;Recording of previous events;Research;Research Personnel;Research Project Grants;Rest;Review Committee;Risk;risk variant;Science;Scientist;Self Administration;Serine;Sodium;Synapses;Technology;Testing;Text;transcriptomics;translational neuroscience

PROJECT_TITLE: Pilot Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurosciences;Nutrition;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Sleep Research;Social Determinants of Health;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PHR: PROJECT NARRATIVE This project will validate low-cost mobile sensors (smartphones, smartwatches, home-based environmental sen- sors) to capture sleep, physical activity, location, and environmental hazards in and around the homes of 1000 Latina women as proxy measures of metabolic syndrome (MetS) risk. The sensing data will be ground-truthed using clinical measures of MetS and models of MetS-related brain vulnerability networks among a subset of participants (n=225). Our transdisciplinary approach uses gold-standard clinical measures to validate integrated measuremnets of mobile sensing devices as a cluster proxy assessment of MetS risk and neuroimaged MetS- related brain vulnerability.

PI_NAMEs: CASTELLI, DARLA M;HALEY, ANDREANA PETROVA (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Affect;Age;Air;Allergens;Behavior;Behavior Therapy;Behavioral;Biological Markers;Blood Glucose;Brain;C-reactive protein;Calibration;Carbon Dioxide;Carbon Monoxide;cardiometabolism;Cause of Death;Cellular Phone;Cerebrum;Child;Cholesterol;Clinical;Clinical assessments;Cohort Studies;Complex;cost;COVID-19 pandemic;Data;Data Analyses;Death Rate;design;Devices;Discipline;Environment;Environmental Exposure;Environmental Hazards;environmental monitoring device;Environmental Risk Factor;experience;Family;fine particles;fitbit;Future;Gases;Glutamates;Goals;gray matter;Health;health assessment;Health behavior;Health Insurance;Heart Diseases;high risk;Home;Home environment;home test;Hour;human old age (65+);Humidity;Hypertension;Hypertriglyceridemia;Individual;Inflammation;instrument;Intervention;Latina;Latina Population;Living Wills;Location;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Metabolic;Metabolic syndrome;Metabolism;Methods;mobile sensing;mobile sensor;Modeling;Monitor;monitoring device;mortality;myoinositol;N-acetylaspartate;National Heart, Lung, and Blood Institute;neuroimaging;Nitrogen Oxides;Noise;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;Particulate Matter;Pathway Analysis;Peripheral;pharmacologic;Physical activity;Physical assessment;pilot test;poor health outcome;Population;Prevalence;prevent;Prevention;protective factors;Protocols documentation;Proxy;Public Health;Quality of life;remote sensing;Research;Rest;Risk;Sampling;sensor;Sleep;Sleep Disorders;smart watch;smartphone application;Smog;synergism;System;Techniques;Telephone;Temperature;Testing;Underserved Population;Validation;ventilation;wearable sensor technology;white matter;White Matter Hyperintensity;White Women;Woman;young adult

PROJECT_TITLE: FEASible: Sensing Factors of Environment, Activity, and Sleep to Validate Metabolic Health Burden Among Latina Women

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: Columbus

ORG_DEPT: NEUROSCIENCES

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because the discovery of mechanisms by which intestinal microorganisms influence the central nervous system is expected to lead to increased understanding and new treatments for many neurological diseases and functional intestinal disorders. The proposed research is therefore relevant to the part of NIH’s mission that pertains to developing fundamental new knowledge that will enhance health and reduce the burdens of illness.

PI_NAMEs: YE, LIHUA  (contact)

PROGRAM_OFFICER_NAME: CUMMINGS, DIANA M

PROJECT_TERMS: Ablation;Address;Affect;Afferent Neurons;Agonist;Anxiety;Award;bacterial genetics;Bacteriology;Behavior;Biological Models;Brain;Brain Diseases;brain pathway;burden of illness;Calcium;career;career development;Catabolism;Cell Physiology;Cell secretion;Cell Transplantation;Cells;Central Nervous System;Chemicals;Communication;detection of nutrient;Development Plans;Diet;Disease;Edwardsiella tarda;Emotions;Enteral;Enterobacteriaceae;Enteroendocrine Cell;Epithelial Cells;Fishes;Functional Gastrointestinal Disorders;Gastroenterology;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;genetic manipulation;Gnotobiotic;Goals;Gram-Negative Bacteria;gut bacteria;gut microbes;gut microbiota;gut-brain axis;Health;Homeostasis;Hormonal;host-microbe interactions;Human;Image;Immunologics;in vivo;Infection;Intestinal Diseases;intestinal epithelium;Intestines;Irritable Bowel Syndrome;Irritants;K-Series Research Career Programs;Knowledge;Link;Measures;Mediating;Mentorship;Microbe;microbial;Microbiology;microorganism;Mission;Molecular;Mus;Nerve Fibers;Nervous System;Nervous System Disorder;neuronal circuitry;Neurons;Neurotransmitters;Nociception;novel;novel therapeutics;Nutrient;Nutritional;optogenetics;Outcome;Pain;pathogen;Pathogenesis;Pathologic;Pathway interactions;Penetration;Peptide Signal Sequences;Perception;peripheral pain;pharmacologic;Pharmacologic Substance;Physiology;pituitary adenylate cyclase activating polypeptide;polypeptide;Postdoctoral Fellow;prevent;Production;psychiatric symptom;Public Health;receptor;Research;Research Personnel;Research Training;response;Scientist;Sensory;Sensory Ganglia;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;skills;Spinal;Stress;System;temporal measurement;Testing;therapeutic development;Training;transmission process;TRPA channel;Tryptophan;United States National Institutes of Health;Universities;Vagus nerve structure;Visceral;Zebrafish

PROJECT_TITLE: Enteroendocrine cells sense gut bacteria and activate a gut-brain pathway

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;HIV/AIDS;Health Services;Infectious Diseases;Prevention;Social Determinants of Health

ORG_CITY: COLUMBIA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: Project Narrative The ongoing COVID-19 pandemic has profoundly affected the HIV prevention and treatment efforts in the Deep South (including South Carolina), which disproportionally endures the dual epidemics of HIV and COVID-19. The HIV service interruptions during COVID-19 pandemic could have long-term negative impacts on people living with HIV and our efforts to end the HIV epidemic by 2030. The proposed research can lead to a better understanding of complicated HIV service interruptions at multiple socioecological levels in SC, the negative effects of such interruptions on key outcomes of the HIV treatment cascade, and the resilience resources that can mitigate these effects.

PI_NAMEs: QIAO, SHAN  (contact)

PROGRAM_OFFICER_NAME: MCKAIG, ROSEMARY G

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;AIDS prevention;antiretroviral therapy;Buffers;care systems;Caring;CD4 Lymphocyte Count;Cellular Phone;Censuses;climate change;Clinic;Clinical;cohort;Collaborations;Communities;COVID-19;COVID-19 outbreak;COVID-19 pandemic;COVID-19 pandemic effects;Data;data infrastructure;Data Reporting;Data Science;Data Set;Deep South;Diagnostic Reagent Kits;Disasters;Disease Progression;Electronic Health Record;Epidemic;Equipment;experience;Focus Groups;Funding;Future;Health;health care availability;Health care facility;Health Personnel;Health Policy;Health Services Accessibility;Health system;HIV;HIV diagnosis;HIV/AIDS;HIV/STD;Hospitals;Human immunodeficiency virus test;Infrastructure;Institution;Interruption;Intervention;Interview;Investigation;Knowledge;Literature;Measures;Medical;Medicine;Modeling;Monitor;Monkeypox;mortality;multiple data types;Nature;Outcome;Outcome Measure;pandemic disease;Patients;Persons;Pharmaceutical Preparations;Policy Making;pre-exposure prophylaxis;pressure;Prevention;promote resilience;Provider;Public Health;public health emergency;Readiness;Recommendation;Research;resilience;resilience factor;Resource Allocation;Resources;response;Risk;Series;service organization;service utilization;Services;social capital;social culture;Social Sciences;Solid;Source;South Carolina;State Government;stay-at-home order;Strategic Planning;supply chain;surveillance data;Surveys;telehealth;Time;transmission process;Travel;United States National Institutes of Health;uptake;Viral;Viral Load result

PROJECT_TITLE: The impacts of HIV-related service interruptions during COVID-19 pandemic in South Carolina

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Clinical Research;Neurosciences;Patient Safety;Substance Misuse

PI_NAMEs: O'MALLEY, STEPHANIE S (contact)

PROJECT_TERMS: Address;Advisory Committees;Alcoholism;Assessment tool;Biometry;Clinical;Clinical assessments;Clinical Research;Clinical Trials Data Monitoring Committees;Common Core;Communities;Data;Data Analyses;data archive;data management;Data Pooling;data structure;Databases;design;Doctor of Philosophy;Enrollment;Ensure;Funding;Genetic;Goals;Human;Image;Methods;Mission;Monitor;National Institute on Alcohol Abuse and Alcoholism;participant safety;Phenotype;Principal Investigator;programs;Protocols documentation;Randomized;recruit;Recruitment Activity;Reporting;Research Personnel;Resources;safety assessment;Science;secondary analysis;Structure;success;Technology;Training;translational neuroscience;United States National Institutes of Health;Update

PROJECT_TITLE: Clinical Core


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_CITY: MORGANTOWN

ORG_DEPT: PHYSIOLOGY

ORG_NAME: WEST VIRGINIA UNIVERSITY

ORG_STATE: WV

PHR: PROJECT NARRATIVE Myocardial ischemia-reperfusion (IR) injury is a major clinical challenge in treating patients suffering from myocardial infarction (MI) as there is no effective therapy to date. In this work, we will employ new mouse models, cell culture, proteomics, molecular and cell biology techniques, and small molecule activators of LonP1 to study the mechanisms of LonP1 mediated cardioprotection in mitigating IR injury. Our proposed work will delineate how LonP1 remodels Complex-I, its integrity, and activity during early IR, thereby reducing excess mtROS and preventing oxidative damage-induced cardiomyocyte death.

PI_NAMEs: SUNDARARAJAN, VENKATESH  (contact)

PROGRAM_OFFICER_NAME: WONG, RENEE P

PROJECT_TERMS: Acetylation;Acute;Animals;Antioxidants;Bioenergetics;biological adaptation to stress;Cardiac;Cardiac Myocytes;cardioprotection;Cause of Death;Cell Culture Techniques;Cell Death;Cell Death Induction;Cellular biology;Cessation of life;Chronic;Clinical;Complex;Data;Dose;Down-Regulation;effective therapy;Electron Transport;Event;Failure;Fibrosis;Free Radicals;Gel;Generations;Glycyrrhetinic Acid;Goals;Heart;Heart failure;heart function;Heart Injuries;Heterozygote;high throughput screening;Histologic;Homeostasis;Hypoxia;improved;In Vitro;in vivo;Infarction;Inflammatory Infiltrate;inhibitor;Intervention;Ischemia;ischemic injury;Ischemic Preconditioning;Knock-out;Knockout Mice;Mediating;Mediator;Mitochondria;Mitochondrial Proteins;Modeling;Molecular;Molecular Biology;mouse model;Mus;Muscle Cells;mutant;Myocardial;Myocardial Infarction;myocardial injury;Myocardial Ischemia;Myocardial Reperfusion Injury;novel;novel therapeutics;Outcome;overexpression;oxidative damage;Oxidative Stress;Oxidative Stress Induction;Patients;Peptide Hydrolases;Physiological;prevent;Production;Proteomics;proteostasis;Publishing;Quality Control;Reactive Oxygen Species;Regulation;Reperfusion Injury;Reperfusion Therapy;Reporting;Role;Signal Transduction;Site;small molecule;Superoxides;Techniques;Terpenes;Testing;Therapeutic;therapeutic evaluation;Tissues;tool;Transgenic Organisms;United States;Work

PROJECT_TITLE: Role of the mitochondrial LonP1 in myocardial ischemia and reperfusion injury protection

STUDY_SECTION: MPPB

STUDY_SECTION_NAME: Integrative Myocardial Physiology/Pathophysiology B Study Section[MPPB]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Hematology;Infectious Diseases;Sepsis

ORG_CITY: DURHAM

ORG_NAME: AIMMAX THERAPEUTICS, INC.

PHR: Project Narrative There were 4.95 million deaths associated with antimicrobial resistance in 2019 worldwide, with antibiotic- resistant Staphylococcus aureus as the leading causative pathogen in the US. More effective antibiotics with unique mechanisms of action are needed to combat the global crisis of antimicrobial resistance, which has further worsened due to COVID-19 pandemic. AimMax Therapeutics seeks to develop a novel antibiotic to treat serious multidrug-resistant gram-positive infections including those with MRSA and VRE.

PI_NAMEs: KEEDY, KARA S (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Accounting;Address;Advanced Development;Adverse event;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;antimicrobial;Antimicrobial Resistance;attributable mortality;bactericide;Biological Assay;Blood;Cessation of life;Clinical;clinical development;combat;Country;COVID-19 pandemic;Data;density;Development;Dosage Forms;Dose;Drug resistance;efficacy study;Ensure;Enterococcus;Evaluation;Excipients;Formulation;Foundations;Future;Generations;Goals;Gram-Positive Bacteria;Gram-Positive Bacterial Infections;Hospitalization;Human;In Vitro;in vivo;Income;Infection;Injectable;Injections;innovation;Intravenous;irritation;Lead;Linezolid;Marketing;Maximum Tolerated Dose;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microbiology;Modeling;Modernization;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;Nature;new chemical entity;Nosocomial Infections;novel;novel therapeutics;Oral;Pain;pathogen;Pattern;Penetration;Phase;Plasma;Predisposition;Prevalence;priority pathogen;Property;prototype;quinupristin-dalfopristin;Recording of previous events;Regimen;Resistance;Resistance development;Ribosomes;Risk;Safety;safety assessment;Sepsis;Septicemia;Site;Small Business Innovation Research Grant;Solid;Staphylococcus aureus;Streptogramins;success;Surveillance Program;Technology;Testing;Therapeutic;Thigh structure;Time;Tissues;Update;Vancomycin Resistance;Vancomycin resistant enterococcus;Vancomycin-resistant S. aureus;Veins;Venous

PROJECT_TITLE: Development of a Novel Injectable Antibiotic to Treat Serious Multidrug-resistant Gram-positive Infections

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Narrative. The diagnosis and prognosis of early stage lung cancer, the leading cause of cancer deaths in the U.S., is challenging and there are no useful biomarkers leading to unnecessary invasive tests and poor outcome among those that have recurrence of disease. In this project, we will uncover microbial and host signatures to develop tests that can predict diagnosis and prognosis of early stage lung cancer.

PI_NAMEs: PASS, HARVEY IRA;SEGAL, LEOPOLDO NICOLAS (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: accurate diagnosis;Applications Grants;biobank;Bioinformatics;Biological Assay;Biological Markers;biological specimen archives;biomarker development;Blinded;Blood;Blood specimen;cancer diagnosis;Cancer Etiology;Cancer Patient;Cancer Prognosis;cancer recurrence;Cessation of life;Chest;Circulation;Clinical;clinical biomarkers;cohort;Collaborations;Culture-independent methods;Custom;Data;Detection;Development;Diagnosis;diagnostic signature;diagnostic strategy;Disease;DNA;Early Detection Research Network;Early Diagnosis;effective therapy;Evaluation Studies;Excision;experience;feature selection;genomic signature;Health;high risk;Histologic;Imaging Techniques;improved;Industrialization;Investigation;Laboratories;Lung;Lung nodule;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;metabolome;metabolomics;metagenome;Metagenomics;microbial;microbial genomics;microbial products;microbial signature;microbiome;Modeling;mortality;multiple omics;nano-string;Nature;next generation sequencing;Nodule;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;Operative Surgical Procedures;Outcome;Patients;Phase;predictive marker;predictive signature;prevent;Procedures;Prognosis;prognostic signature;prospective;Publishing;Recurrence;Recurrent disease;Research Design;Resectable;Resources;respiratory microbiota;Risk;RNA;sample collection;Sampling;Specimen;targeted biomarker;Testing;Thoracotomy;Tissue Sample;TNM;transcriptome;transcriptomics;Treatment Failure;Work

PROJECT_TITLE: Microbial and host biomarker development for detection and prognosis of early stage non-small cell lung cancer


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Substance Misuse

PI_NAMEs: GELERNTER, JOEL  (contact)

PROJECT_TERMS: Alcohol abuse;Alcohol dependence;alcohol risk;alcohol use disorder;Alcoholism;Alcohols;All of Us Research Program;Archives;arm;Atlases;Big Data;Biometry;Brain;central database;Clinical;Collaborations;Communities;computational neuroscience;Computer Models;Computer software;connectome;Consultations;Data;data acquisition;Data Collection;data framework;data management;Data Set;Databases;DNA;Electroencephalography;Enrollment;Environment;Epigenetic Process;European ancestry;Fiber;Frequencies;Functional Magnetic Resonance Imaging;Genetic;Genetic Risk;Genetic study;genome wide association study;Genotype;Goals;Human;human subject;Image;Informatics;Infrastructure;innovation;interest;Investments;Laboratories;life span;Measures;Meta-Analysis;Methodology;Methods;Mission;Modality;Modeling;Molecular;Molecular Analysis;multimodal neuroimaging;multimodality;neural;neuroimaging;neuroinformatics;novel;Outcome;parallel processing;Patient Recruitments;Pattern;Pharmacogenomics;pharmacologic;Phenotype;Photometry;Pilot Projects;polygenic risk score;Population;Population Group;Procedures;Productivity;Protocols documentation;quality assurance;Research Design;Research Personnel;Resolution;Resources;risk variant;Sampling;Site;Standardization;Statistical Data Interpretation;Structure;Study Subject;Substance Addiction;success;System;Techniques;Technology;temporal measurement;Testing;tool;trait;transcriptomics;translational neuroscience;Work

PROJECT_TITLE: Translational Technologies Core


PI_NAMEs: SEGAL, LEOPOLDO NICOLAS (contact)

PROJECT_TERMS: Administrator;Agreement;Award;Biological Assay;Biological Markers;biomarker development;biomarker validation;Cancer Center;Clinic;Collaborations;data integration;data sharing;Detection;Disease;Early Detection Research Network;Early Diagnosis;Ensure;Evaluation;Excision;Goals;Individual;Infrastructure;insight;Institutional Review Boards;Investigation;Laboratories;Lead;Leadership;Malignant neoplasm of lung;Manuals;microbial;Monitor;Morbidity - disease rate;mortality;Nature;New York;Non-Small-Cell Lung Carcinoma;Periodicals;predictive marker;Procedures;Prognosis;programs;Progress Reports;Research;Research Personnel;Residual Neoplasm;Resource Sharing;Resources;Standardization;Teacher Professional Development;Techniques;Technology;Time;Translating;translational impact;Universities;usability;Work

PROJECT_TITLE: Administrative Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Chronic Pain;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pain Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Violence Research

ORG_CITY: HOUSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF HOUSTON

PHR: PROJECT NARRATIVE The co-occurrence of hazardous drinking exacts a significant burden on patients, providers, and health care systems. In line with NIAAA initiatives to increase greater understanding of individual differences factors that may underlie the etiology and maintenance of alcohol misuse and its comorbidities and NIH’s UNITE initiative’s aim to support “new research on health disparities, minority health, and health equity,” the proposed work will examine the influence of microaggressions (MAs) (accounting for non-discriminatory daily stress) on alcohol use motivation, drinking, and alcohol-related problems as well as pain experience among non-Latinx Black adults who are hazardous drinkers with chronic pain. Through this research, we also will explore mediational processes and moderators in the MA-hazardous drinking/pain relations that will inform future intervention and prevention efforts for this neglected health disparities group. 3

PI_NAMEs: SMIT, TANYA  (contact)

PROGRAM_OFFICER_NAME: RUFFIN, BEVERLY

PROJECT_TERMS: Accounting;Adult;Affect;Alcohol consumption;alcohol craving;Alcohol dependence;alcohol misuse;alcohol misuse prevention;alcohol related consequences;alcohol related problem;alcohol use disorder;Alcohols;American;Area;binge drinking;Black Populations;Black race;chronic pain;comorbidity;comparative;coping;Crime;Data;demographics;disability;Disparity;distress tolerance;drinking;emotional symptom;ethnic identity;Ethnic Origin;Etiology;experience;Female;Frequencies;Future;Goals;hazardous drinking;health disparity;health disparity populations;health equity;Healthcare Systems;high risk drinking;improved;Individual;Individual Differences;Intention;Intervention;Link;Maintenance;male;marginalized population;Mental Health;Methodology;microaggression;Minority;minority health;minority stress;Modeling;Motivation;National Institute on Alcohol Abuse and Alcoholism;Nature;neglect;Neighborhoods;non-verbal;Outcome;Pain;Pain intensity;Pain interference;Participant;Patients;Pattern;perceived discrimination;Persons;physical conditioning;poor health outcome;Population;Populations at Risk;Poverty;Prevalence;preventable death;Prevention;Process;Provider;psychologic;Public Health;Race;racial discrimination;racism;Recurrence;Religiosity;Reporting;Research;Research Project Grants;Research Support;resilience factor;Risk;Role;Sampling;social;Strategic Planning;Stress;stressor;substance use;Symptoms;Testing;Thinking;time use;United States National Institutes of Health;verbal;Work

PROJECT_TITLE: Microaggressions and Hazardous Drinking among non-Latinx Black Individuals with Chronic Pain


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Microbiome;Precision Medicine;Prevention

PROJECT_TERMS: Archives;artificial intelligence method;biobank;Biological Markers;biomarker development;biomarker signature;Blood specimen;Blood Tests;cancer diagnosis;Cancer Prognosis;cancer recurrence;cancer type;Cells;Circulation;Clinical;cohort;Collaborations;Complex;Credentialing;Culture-independent methods;Data;Detection;Development;Diagnosis;diagnostic biomarker;Diagnostic Procedure;diagnostic strategy;Disease;DNA;DNA Markers;early detection biomarkers;Early Detection Research Network;Early Diagnosis;Environment;Evaluation;Excision;follow-up;Foundations;genomic signature;Genomics;Goals;Grant;high risk;Histologic;host-microbe interactions;Imaging Techniques;immunoregulation;improved;In Situ;Individual;Investigation;Laboratories;laboratory development;Lesion;Lung Adenocarcinoma;lung cancer screening;Lung Diseases;Lung Neoplasms;Lung nodule;Malignant - descriptor;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolism;metabolome;metabolomics;metagenome;Metagenomics;Microbe;microbial;microbial signature;microbiome;minimally invasive;Modeling;Multiomic Data;multiple omics;nano-string;Nodule;Non-Malignant;Non-Small-Cell Lung Carcinoma;novel;novel marker;Operative Surgical Procedures;Oral;Pathway interactions;Patients;Performance;Perioperative;Plasma;potential biomarker;predictive marker;predictive signature;prevent;Process;Prognosis;Publishing;Recurrence;Recurrent disease;Risk;Sampling;Sensitivity and Specificity;Shotguns;specific biomarkers;Statistical Models;Systems Biology;Testing;Thoracotomy;Time;Tissue Sample;Tissues;TNM;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Validation

PROJECT_TITLE: Biomarker Development Laboratory


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Drug Abuse (NIDA only);Mental Health;Natural Products;Pediatric;Social Determinants of Health;Substance Misuse

ORG_CITY: Aurora

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: As more states have legalized cannabis, high-potency products such as concentrates have become more popular. However, very little is known about how the use of these products affects mental health or psychosocial functioning. Given the increasing prevalence of concentrate use, it is imperative to clearly understand how these increasingly popular, high-potency cannabis products affect mental health outcomes. This project will examine how concentrate use affects mental and psychosocial functioning by examining concentrate users over time, and also, by utilizing a co-twin control design, compare twins who use concentrates with their co-twin.

PI_NAMEs: HOPFER, CHRISTIAN J (contact)

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: Accounting;Acute;Adolescence;Affect;Anxiety;Blood;Cannabinoids;Cannabis;Cannabis policy;Cannabis retail;Consumption;Controlled Study;Data;design;Dose;Drug usage;Education;Exhibits;Family;Flowers;Frequencies;Functional disorder;Genetic;Impulsivity;Individual;Individual Differences;Intoxication;Legal;Link;Literature;low socioeconomic status;marijuana legalization;marijuana use;Marketing;Measures;Mental Depression;Mental Health;Methods;Neurocognitive;Outcome;Participant;Persons;Plasma;Prevalence;Psyche structure;Psychopathology;psychosocial;psychosocial outcome;public health relevance;Reporting;Research;response;Risk;Risk Factors;Sales;Sampling;substance use;Symptoms;Testing;THC exposure;Time;Titrations;Twin Multiple Birth;Twin Studies;United States;Whole Blood;Work

PROJECT_TITLE: Effects of High Potency Cannabis Products on Mental Health and Psychosocial Functioning

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Lung;Lung Cancer;Precision Medicine;Prevention

PROJECT_TERMS: Adjuvant;Benign;Biological Assay;Biological Markers;biomarker development;biomarker validation;Blood;Blood specimen;cancer diagnosis;Cancer Patient;cancer recurrence;Clinical;Clinical Laboratory Improvement Amendments;cohort;Collaborations;Cost efficiency;Custom;Data;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;Disease;DNA;DNA Probes;Early Detection Research Network;Early identification;Evaluation;Excision;experience;Freezing;Genes;Genetic Markers;Genome;genomic signature;Goals;high risk;Infrastructure;Intervention;Investigation;Laboratories;Malignant neoplasm of lung;Malignant Neoplasms;Measures;metabolome;metagenome;Metagenomics;microbial;microbial genomics;microbial signature;microbiome;nano-string;Nature;Neoadjuvant Therapy;next generation sequencing;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Patients;Plasma;predictive signature;prevent;Procedures;Prognosis;prognostic;Recurrence;Reproducibility;risk prediction;RNA;Role;Sampling;sequencing platform;Standardization;Sterility;Structure of parenchyma of lung;targeted sequencing;Testing;Tissue Sample;Tissues;transcriptome;Validation;Work

PROJECT_TITLE: Biomarker Reference Lab


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Cytokine-induced memory-like (ML) NK cells are a promising cellular therapy for treating hematological malignancies as demonstrated in early phase clinical trials. This proposal aims to understand the mechanisms underlying NK cell reprogramming. These findings will provide insights on how to improve ML NK cells in the clinic on treating malignancies.

PI_NAMEs: TRAN, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: Acute Myelocytic Leukemia;ATAC-seq;B-Lymphocytes;Binding;Biological Assay;cancer cell;CD8-Positive T-Lymphocytes;Cell Differentiation process;Cell division;Cell Nucleus;Cell Physiology;Cell Reprogramming;Cell Therapy;Cells;Cellular biology;Chromatin;Cleavage Under Targets and Release Using Nuclease;Clinic;Clinical;clinical application;clinical efficacy;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;comparison control;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;cytokine;Cytokine Activation;cytotoxicity;Data;Development;differentiation in vitro;Disease;Disease remission;DNA Binding;early phase clinical trial;Epigenetic Process;Exhibits;Future;Gene Expression;Gene Expression Profile;Genes;Genetic Transcription;Goals;Haptens;Hematologic Neoplasms;Hematopoietic stem cells;Heterogeneity;Host Defense;Human;IL18 gene;improved;in vivo;insight;Interleukin-12;Interleukin-15;Intervention;knock-down;Knock-out;Ligation;Lymphocyte;Lymphoid Cell;Malignant Neoplasms;Measures;Mediating;Memory;Modification;Molecular;multiple omics;Mus;Natural Killer Cells;neoplastic cell;NK cell therapy;novel;novel strategies;Patients;Phase;Phase I Clinical Trials;Phenotype;Play;prevent;Process;Production;programs;Proteins;Receptor Activation;Refractory;Relapse;response;Role;Safety;Signal Transduction;single-cell RNA sequencing;T-Lymphocyte;Techniques;Testing;Transcript;transcription factor;transcriptional reprogramming;transcriptome sequencing;tumor;Up-Regulation;Virus Diseases

PROJECT_TITLE: Elucidating the role of EOMES in Memory-Like NK cell Differentiation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Hematology;Lung;Rare Diseases;Sickle Cell Disease

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: Recent studies demonstrated that red blood cells (RBCs) play an active role in venous thromboembolism (VTE). RBC abnormalities observed in sickle cell disease (SCD) influence venous clot structure, resulting in an unusually high incidence of pulmonary embolism (PE) relative to deep vein thrombosis - a phenomenon which we have termed “the sickle cell paradox”. This paradox is also seen in subjects with sickle cell trait. This proposal aims to identify the best approach to attenuate this disease-specific form of VTE through a greater in- depth understanding of the mechanisms of thrombosis.

PI_NAMEs: KEY, NIGEL S.;PAWLINSKI, RAFAL L (contact)

PROGRAM_OFFICER_NAME: QASBA, PANKAJ

PROJECT_TERMS: Abnormal Red Blood Cell;Address;Animal Model;Antifibrinolytic Agents;Attenuated;Birth Rate;Blood;Blood coagulation;Blood Platelets;Blood Vessels;Cardiovascular Diseases;Chronic;Clinical;clinical phenotype;clinically relevant;Coagulation Process;Cohort Studies;Data;Deep Vein Thrombosis;Defect;Disease;Erythrocytes;Event;factor V Leiden;Femoral vein;Fibrin;Fibrinolysis;Generations;Goals;Hematological Disease;Hemoglobin;Hemolytic Anemia;High Prevalence;Human;Hypoxia;In Vitro;Incidence;Individual;Inherited;inhibitor;Ischemic Stroke;Kininogenase;Link;Lung;Mediating;microvesicles;Molecular;mortality;mouse model;Mus;Mutation;Myocardial Infarction;Myocardial Ischemia;Organ;Pathologic;Pathway interactions;Patients;Plasma Kallikrein;Platelet Count measurement;Play;Predisposition;Principal Investigator;programs;Property;Pulmonary Embolism;Recurrence;Reporting;Resistance;response;restoration;Risk;Role;Sickle Cell;Sickle Cell Anemia;Sickle Cell Trait;sickling;Structure;Therapeutic Embolization;Thrombin;Thrombophilia;Thrombosis;Thrombus;Time;trait;United States;Venous;venous thromboembolism;Whole Blood

PROJECT_TITLE: Mechanism of sickle cell disease-specific venous thromboembolism

STUDY_SECTION: HT

STUDY_SECTION_NAME: Hemostasis and Thrombosis Study Section.  Committee was terminated on 11/30/2020. [HT]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative Our research is relevant to public health because it addresses the most relevant shortage of organs for transplantation. Optimizing the utilization and outcomes of older transplanted organs is expected to reduce mortality and morbidity rates of wait-listed patients with end-stage-organ-failure. Understanding the impact of aging on inflammation is highly relevant to public health as it addresses an area of increasing clinical significance and our proposal is of high translational relevance as it dissects mechanisms of inflamm-aging and offers novel treatments that improve organ quality and transplant outcomes.

PI_NAMEs: TULLIUS, STEFAN GUNTHER (contact)

PROGRAM_OFFICER_NAME: TILAHUN, MULUALEM ENYEW

PROJECT_TERMS: Acute;Address;Affect;Age;age acceleration;age effect;age related;Aging;aging population;Allografting;Animal Model;animal old age;Animals;Anti-Inflammatory Agents;Area;Automobile Driving;BAX gene;Cell Aging;Cell Cycle Kinetics;Cell Membrane Permeability;Cells;Chronic;Clinical;Clinical Research;clinically relevant;clinically significant;Collection;Communication;cytokine;Data;Death Rate;Dendritic cell activation;Dendritic Cells;Deterioration;Dialysis procedure;Disease;end-stage organ failure;experience;Experimental Models;experimental study;Goals;Graft Survival;Health;Human;human old age (65+);IL17 gene;Immune response;Immunocompetence;immunogenicity;Impairment;improved;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Injury;injury and repair;Ischemia;isoimmunity;Ligands;Mediating;Mitochondrial DNA;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Nitrogen;novel;old mice;older patient;Older Population;Organ;Organ Donor;organ injury;organ transplant recipient;Organ Transplantation;Outcome;Outer Mitochondrial Membrane;Pathway interactions;Patients;Pattern;permease;Population;pre-clinical;preclinical study;preservation;Process;Public Health;receptor;repaired;Reperfusion Injury;Research;Research Personnel;response;Risk;Role;senescent cell;senolytics;Signal Pathway;Signal Transduction;Source;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Time;Transplantation;treatment choice;Waiting Lists

PROJECT_TITLE: Senescent cells drive mt-DNA accumulation and inflamm-aging

STUDY_SECTION: ASG

STUDY_SECTION_NAME: Aging Systems and Geriatrics Study Section[ASG]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Public health relevance/ project narrative. Since anemia affects ~30% of persons worldwide and is a major cause of morbidity, understanding red cell maturation is important. By investigating mouse models in vivo and cells from Diamond Blackfan anemia (DBA) patients in vitro, we will determine how and why red cell precursors die. These studies should provide insights into the molecular and cellular processes regulating normal red cell differentiation and should define new therapeutic strategies to ameliorate anemia in DBA and other disorders characterized by ineffective red cell differentiation.

PI_NAMEs: ABKOWITZ, JANIS L (contact)

PROJECT_TERMS: Adult;Affect;alpha-glycerophosphoric acid;Amino Acids;Anemia;Binding;Biological Models;Carrier Proteins;Cell Death;Cell Differentiation process;Cell Maturation;Cell model;Cell Physiology;Cell surface;Cell Surface Proteins;Cell Surface Receptors;Cells;CFU-E;Chemicals;chromosome 5q loss;Circadian Rhythms;Citric Acid Cycle;clinical phenotype;Complementary DNA;Cytokine Receptors;Data;Decision Making;design;Diamond-Blackfan anemia;Disease;Dominant-Negative Mutation;Dysmyelopoietic Syndromes;Effectiveness;Enzymes;Erythrocytes;Erythroid Cells;erythroid differentiation;Erythropoiesis;Event;expression cloning;Feline Leukemia Virus;feline leukemia virus receptor;Felis catus;Globin;Glycine;Goals;Grant;Heme;Hemoglobin;Human;Impairment;In Vitro;in vitro Model;in vivo;in vivo Model;Individual;Inorganic Phosphate Transporter;insight;Investigation;Iron;Kinetics;lactose permease;Link;Macrocytic Anemia;Marrow;member;Metabolic;metal transporting protein 1;Methods;Modeling;Molecular;Morbidity - disease rate;mouse model;Mus;novel;novel therapeutic intervention;novel therapeutics;Observational Study;Oxalates;Pathogenesis;Pathway interactions;Patients;Persons;Physiological;Physiology;Population;prevent;Process;Production;Pronormoblasts;protein expression;protein structure;Proteins;public health relevance;receptor;response;Ribosomal Proteins;Ribosomes;Safety;sensor;Series;Signal Pathway;single cell analysis;single cell technology;Subgroup;Surface;Testing;Thalassemia;time interval;Toxic effect;trafficking;transcriptome;Translations;Ubiquitination

PROJECT_TITLE: Heme synthesis, use and trafficking during erythropoiesis

STUDY_SECTION: MCH

STUDY_SECTION_NAME: Molecular and Cellular Hematology Study Section[MCH]


ORG_CITY: Parkville

ORG_COUNTRY: AUSTRALIA

ORG_FIPS: AS

ORG_NAME: WALTER AND ELIZA HALL INST MEDICAL RES

PHR: Project narrative There are several common barriers to malaria elimination that countries in the Asia-Pacific region are facing – increasingly heterogenous transmission driven by asymptomatic infections, environmental change affecting malaria ecology, emerging drug and insecticide resistance, the resilience of P. vivax malaria and resource constraints. We will address these barriers to elimination through a coordinated program of epidemiological and transmission studies that combines epidemiological, clinical and entomological investigations, innovative molecular and serological diagnostics with advanced mathematical transmission modelling across 5 field sites in Cambodia and Papua New Guinea that span the transmission gradient from very low to high. By developing better surveillance approaches that allow better targeting of intervention, improving P. vivax case management, monitoring the changing vector distribution and behavior and tracking the spread of drug and insecticide resistance, evidence from our research will inform program action to accelerate towards zero malaria in the region.

PI_NAMEs: MUELLER, IVO J (contact);ROBINSON, LEANNE

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Acceleration;Address;Affect;Artemisinins;Asia;Behavior;Cambodia;Case Management;climate impact;Clinical;Country;Coupled;Culicidae;Data;Decision Making;density;design;Detection;Development;Diagnosis;diagnostic assay;Diagnostic tests;Drug resistance;Ecology;Effectiveness;Ensure;environmental change;Epidemiology;Face;Genes;Genetic study;Genetic Vectors;Genomics;Glucosephosphate Dehydrogenase Deficiency;Goals;Health care facility;Human;human monoclonal antibodies;Improve Access;improved;Infection;innovation;Insecticide Resistance;Interruption;Intervention;Investigation;Laboratories;land use;Link;Malaria;malaria transmission;Maps;Mathematics;Measures;Mefloquine;Modeling;Molecular;molecular marker;Monitor;Nature;novel;Observational epidemiology;Outcome;Papua New Guinea;Parasites;Pattern;Pharmaceutical Preparations;Plasmodium falciparum;Plasmodium vivax;Policies;Policy Maker;Population;population survey;Prevalence;Primaquine;programs;Property;pyrethroid;Research;Residual state;resilience;Resistance;resistance mutation;Resources;response;Serodiagnoses;Site;Study models;success;Surveys;System;Techniques;tool;transmission blocking;transmission process;trend;Vaccines;vector;vector control;Vivax Malaria

PROJECT_TITLE: Understanding and Targeting the Barriers to Effective Malaria Control and Elimination in the Asia-Pacific Region

STUDY_SECTION_NAME: Special Emphasis Panel[ZAI1 CAB-M (J1)]


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: MUELLER, IVO J (contact)

PROJECT_TERMS: Administrator;Agreement;Asia;Australia;Award;Biological;Biology;Budgets;Cambodia;Collaborations;Communication;Communities;Country;Data;Data Coordinating Center;data management;data sharing;design;Diagnostic;Documentation;Education;Ensure;Epidemiology;Ethics;Expenditure;experience;Genomics;Goals;Guidelines;Human;Institution;interdisciplinary approach;International;Laboratories;Laboratory Research;Leadership;Legal;Malaria;Medical Research;member;Methodology;Modeling;Molecular;Monitor;National Institute of Allergy and Infectious Disease;Observational Study;Occupational activity of managing finances;operation;Output;Papua New Guinea;Parasites;Policies;Productivity;Program Reviews;programs;Protocols documentation;Regulation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Sampling;Serology;Site;Structure;support network;Technology;Training;transmission process;United States National Institutes of Health;vector;Writing


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Acceleration;Address;Affect;Area;Asia;Biological;Brazil;Cambodia;co-infection;Collaborations;Collection;Communities;Complex;complex data;Computer software;Computers;Country;dashboard;Data;data cleaning;data complexity;data dashboard;data integration;data management;Data Management Resources;data quality;data repository;Data Set;data sharing;database design;Databases;design;Development;Drops;Educational workshop;electronic data;electronic data capture system;Epidemiology;evidence base;experience;Expert Opinion;field study;flexibility;Formulation;General Population;handheld equipment;Health Personnel;Heterogeneity;Immunologics;improved;in silico;Individual;infectious disease model;interest;Intervention;Joints;Knowledge;knowledge translation;Laboratories;Link;Local Government;Location;Malaria;malaria transmission;Manuals;mathematical model;Mathematics;Measures;Modeling;Molecular;network models;novel;novel strategies;Online Systems;Outcome;Paper;Paris, France;Participant;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Play;point of care;Policies;Policy Maker;Policy Making;Population;Probability;Procedures;Process;programs;Public Health;public health intervention;public repository;Randomized, Controlled Trials;Research;Research Personnel;Resource Allocation;response;Role;Running;Sentinel;Site;Statistical Data Interpretation;Statistical Models;Study models;support network;System;Tablets;Testing;Time;time use;tool;Translating;Translations;transmission process;Tupaia;Universities;vector;Work

PROJECT_TITLE: Data Management, Statistical Support and Modelling Core


NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: ROBINSON, LEANNE  (contact)

PROJECT_TERMS: Acceleration;Address;Aminoquinolines;Anti-malarial drug resistance;Artemisinins;Asia;Biometry;Cambodia;Case Management;Clinical;Combined Modality Therapy;Communities;Country;Cross-Sectional Studies;Culicidae;Data;density;Detection;Diagnosis;Diagnostic;diagnostic strategy;Diagnostic tests;diagnostic tool;Drug resistance;effective therapy;efficacy evaluation;efficacy study;Ensure;Epidemiology;Erythropoiesis;experience;exposed human population;Exposure to;Genetic;genomic data;Genomics;Geography;Glucosephosphate Dehydrogenase Deficiency;Goals;Health care facility;Heterogeneity;Immunity;Immunology;improved;In Vitro;in vivo;Incidence;Infection;Insecticide Resistance;Intervention;Knowledge;Learning;Malaria;malaria infection;Malaria prevention;malaria transmission;mathematical model;Modeling;Molecular;Monitor;novel;Parasites;Pharmaceutical Preparations;Plasmodium;Plasmodium falciparum;Plasmodium vivax;Play;point-of-care diagnostics;Policies;Population;Populations at Risk;Positioning Attribute;Predisposition;pressure;prevent;Relapse;Residual state;Resistance;Resolution;Resource Allocation;response;Risk;Role;Sampling;Serology;serosurveillance;Site;Structure;success;tool;transmission process;Treatment Efficacy;treatment guidelines;trend;vector mosquito;Vivax Malaria

PROJECT_TITLE: Project 1 - Epidemiology


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: KARL, STEPHAN  (contact)

PROJECT_TERMS: Acceleration;Address;Anopheles Genus;anthropogenesis;Area;Asia;Automobile Driving;Beds;Behavior;Biological Assay;Biometry;Bite;Cambodia;climate change;climate impact;Clinical;cost effectiveness;Country;COVID-19 pandemic;Culicidae;Data;Deforestation;Development;Diagnostic;drug candidate;Effectiveness;Environment;environmental change;Environmental Impact;Evaluation;experience;Exposure to;forest;Funding;Future;Genetic Polymorphism;genomic tools;Genomics;Goals;high risk population;Human;Human body;Human Genetics;improved;Incidence;Insecticide Resistance;Insecticides;Intervention;Knowledge;Learning;Libraries;Link;Location;Malaria;Malaria prevention;malaria transmission;Maps;Modeling;Molecular;New Territories;novel;occupational hazard;Papua New Guinea;Parasites;Pathway interactions;Performance;Plasmodium falciparum;Plasmodium vivax;Policies;Population;programs;pyrethroid;Research;Resistance;resistance mutation;Sampling;Series;Site;Structure;success;Surveillance Program;surveillance strategy;Surveys;Testing;tool;transmission blocking;transmission process;transmission-blocking vaccine;vaccine candidate;vector;vector control;Vector Ecology;vector mosquito;Vivax Malaria;Vulnerable Populations

PROJECT_TITLE: Project 2 - Transmission


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;HIV/AIDS;Infectious Diseases;Nutrition

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Disruption of intestinal homeostasis is a major cause of sustained inflammation in people with HIV (PWH) despite antiretroviral therapy and this leads to increased morbidity and mortality due to inflammatory non-communicable diseases (NCDs) such as diabetes, cardiovascular disease, obesity, and end organ damage. Maintenance of intestinal homeostasis requires coordinated functions of tissue resident immune cells and several epithelial cell lineages; therefore, this proposal will characterize the mechanistic role of intestinal CD8+ T cell immunometabolic function and its contribution to maintaining epithelial homeostasis. Results from this work will provide new insights to develop novel strategies to target mucosal CD8+ T cells and improve health outcomes for PWH.

PI_NAMEs: DAS ADHIKARI, UPASANA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 3-Dimensional;Agonist;antagonist;antiretroviral therapy;Apoptosis;Autologous;Biogenesis;Biopsy;Cardiovascular Diseases;career development;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Death;cell injury;Cell Lineage;Cell Physiology;Cells;Chemicals;Chronic;Circulation;Coculture Techniques;Colitis;Collaborations;Colon;comorbidity;cytokine;Diabetes Mellitus;Disease;Down-Regulation;effector T cell;Energy Metabolism;Epithelial Cells;Epithelium;Family;fatty acid oxidation;Fatty Acids;Flow Cytometry;Functional disorder;Genetically Engineered Mouse;Health;HIV;HIV Infections;Homeostasis;human subject;Immune;immune activation;immune function;Immunohistochemistry;Immunology;Immunophenotyping;Impairment;improved;in vivo;Individual;Inflammation;Inflammatory;Inflammatory Bowel Diseases;inhibitor;insight;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestines;Isotopes;Knockout Mice;Link;lipid metabolism;Lipids;Liver diseases;Maintenance;Malignant Neoplasms;Measures;Mediating;Memory;Metabolic;Metabolism;microbial;microbial products;Mitochondria;Molecular;Morbidity - disease rate;mortality;Mucous Membrane;Mus;novel strategies;novel therapeutic intervention;Obesity;Organ;Organoids;Outcome;Palmitic Acids;Pathogenesis;Pathology;Patients;Permeability;Peroxisome Proliferator-Activated Receptors;Persons;Phase;Population;prevent;Process;Production;receptor;Receptor Signaling;Role;Signal Induction;Signal Pathway;systemic inflammatory response;Tissues;Transcription Coactivator;transcriptomics;tumor microenvironment;Wild Type Mouse;Work

PROJECT_TITLE: Impact of HIV-associated intestinal CD8+ T cell function in mucosal homeostasis


ORG_CITY: LONDON

ORG_COUNTRY: UNITED KINGDOM

ORG_FIPS: UK

ORG_NAME: LONDON SCH/HYGIENE & TROPICAL MEDICINE

ORG_ZIPCODE: WC1E 7HT

PHR: OVERALL NARRATIVE Despite significant reductions in cases, malaria remains a major public health problem in India, the world's most populous country, causing important morbidity and mortality. The Center for the Study of Complex Malaria in India is a collaborative scientific research institute comprising United Kingdom, United States, and India malaria experts and dedicated staff at four field sites, working towards the goal of enhancing malaria intervention and control programs in India.

PI_NAMEs: MOHANTY, SANJIB ;WASSMER, SAM  (contact)

PROJECT_TERMS: Adult;Anopheles Genus;Antibodies;Area;Automobile Driving;Benchmarking;Biological Assay;Biological Markers;biomarker discovery;biomarker identification;Biostatistics Core;Brain;Chronic;circulating biomarkers;circulating microRNA;cohort;Communities;community transmission;Complex;Country;data management;Dedications;deep learning;Democracy;density;design;Detection;Diagnostic;diagnostic biomarker;diagnostic strategy;diagnostic tool;disability;Epidemiology;evidence base;Face;Failure;Falciparum Malaria;Fever;follow-up;Frequencies;Gene Deletion;Goals;health assessment;Healthcare;Histopathology;Human;India;Individual;Infection;Inflammation;Insecticides;Intervention;Investigation;Knowledge;Lead;Low Prevalence;Machine Learning;machine learning model;Maintenance;Malaria;malaria infection;malaria transmission;Methods;Molecular Diagnostic Techniques;Monitor;Morbidity - disease rate;mortality;neglect;Neurocognition;Neurocognitive;neuroimaging;novel;novel diagnostics;operation;Parasites;Patients;Pattern;peripheral blood;Plasma;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium ovale;Plasmodium vivax;Play;Prevalence;primary outcome;programs;Prospective cohort;Prospective, cohort study;Proteins;Proteome;Proteomics;Public Health;Pyroxylin;rehabilitation strategy;Research;Research Institute;Research Project Grants;Resistance;Retina;retinal imaging;Role;Sampling;Sensitivity and Specificity;Serology;Severity of illness;Site;Spleen;Splenectomy;Techniques;test strip;tool;transcriptome sequencing;transmission process;Traumatic injury;United Kingdom;United States;Validation;vector;Vector Ecology;Visit


PI_NAMEs: WASSMER, SAM  (contact)

PROJECT_TERMS: Accounting;Award;Books;Budgets;Collaborations;Communication;Communication Methods;Complex;conflict resolution;Data;Educational workshop;Electronic Mail;Ensure;Expenditure;experience;Funding;Goals;Grant;Hour;India;Institution;Logistics;Malaria;meetings;member;Methods;Monitor;National Institute of Allergy and Infectious Disease;Participant;Policies;Policy Maker;programs;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Resources;Seasons;Series;Side;Site;Specialist;Structure;System;Telephone;Testing;Time;Translations;Travel;Vendor


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Adherence;Bioinformatics;Biostatistics Core;Code;Communities;Complex;Computer software;Data;Data Analyses;data management;data quality;data repository;Data Set;data sharing;Data Storage and Retrieval;Databases;design;Development;digital;electronic data;Electronics;Ensure;Epidemiology;Genbank;Goals;Government;Guidelines;Hospitals;India;instrument;Malaria;Manuscripts;Maps;National Institute of Allergy and Infectious Disease;Online Systems;Procedures;Progress Reports;Protocols documentation;Reading;Reporting;Research Design;Research Personnel;Resources;Secure;Services;Site;Surveys;Tablets;timeline;tool;Translating;United States National Institutes of Health;vector;Visualization

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Affect;Anopheles Genus;Antibodies;Area;Automobile Driving;Behavior;Biological Assay;Biological Markers;biomarker identification;Bite;Blood;Blood Vessels;Caring;Cattle;chronic infection;Clinical;cohort;Collection;Communities;Community Health Education;comparative;Complex;Data;density;design;Detection;Development;Diagnosis;Diagnostic;diagnostic strategy;diagnostic tool;Failure;Fever;Frequencies;Gene Deletion;Genes;Genotype;Goals;Hand functions;Healthcare;High Prevalence;Histopathology;Household;Human;improved;India;Individual;Infection;Insecticides;Intervention;Investigation;Knowledge;Light;Machine Learning;Maintenance;Malaria;malaria transmission;Mass Screening;Measures;Methods;Microscopy;Modeling;Molecular;molecular array;molecular diagnostics;Monitor;Morbidity - disease rate;mortality;novel strategies;Parasitemia;Parasites;Participant;participant enrollment;Pattern;Plasmodium;Plasmodium falciparum;Plasmodium ovale;Plasmodium vivax;Play;Predisposition;Prevalence;primary outcome;Production;programs;Prospective, cohort study;Pyrethrum;Reporting;Research;Role;sample collection;Sampling;Seasons;sex;Site;specific biomarkers;Spleen;Surrogate Markers;Surveys;Testing;Time;tool;transmission process;Treatment Failure;vector;vector control;Vector Ecology;Visit

PROJECT_TITLE: PROJECT 1: Identifying Reservoirs of Plasmodium Infections in Odisha, India


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Neurosciences;Precision Medicine;Prevention;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Address;Adult;Affinity;Antigen Targeting;Area;Benchmarking;Binding Proteins;Biological Markers;biomarker identification;biomarker signature;Blood specimen;Brain;Brain region;candidate identification;candidate marker;carrier testing;Categories;Cerebral Malaria;Cerebrum;Characteristics;chromosomal location;Chromosome Positioning;circulating biomarkers;circulating microRNA;Clinical;Code;cognitive change;Complex;Data;Data Set;deep learning;design;Detection;detection method;detection test;Development;Diagnosis;diagnostic biomarker;Diagnostic tests;diagnostic tool;disability;Evaluation;experimental study;Falciparum Malaria;follow-up;Genes;Genome;Goals;High Prevalence;Image;imaging modality;Immobilization;India;Individual;Infection;innovation;Laboratories;Language;Logistics;Magnetic Resonance Imaging;Malaria;malaria transmission;Measures;Methods;MicroRNAs;Mining;Modeling;Neurocognitive;Neurocognitive Deficit;neuroimaging;Neurologic;novel;novel diagnostics;Parasites;Patients;Plasma;Plasmodium;Plasmodium falciparum;Plasmodium falciparum genome;Plasmodium genome;Prevalence;primary outcome;Prognosis;programs;protein biomarkers;Protein Engineering;protein function;Proteins;Proteome;proteomic signature;Proteomics;Pyroxylin;rapid detection;rehabilitation strategy;Reporting;Research;Residual state;Retina;Risk;Sampling;screening;Sensitivity and Specificity;Severity of illness;Site;Spleen;Splenectomy;Techniques;Technology;test strip;Testing;Time;tool;transcriptome sequencing;Validation;Work

PROJECT_TITLE: Project2: Developing New Diagnostic Tools for the Detection of Plasmodium Infection Across the Spectrum of Disease Severity


ORG_CITY: BLANTYRE

ORG_COUNTRY: MALAWI

ORG_FIPS: MI

ORG_NAME: KAMUZU UNIVERSITY OF HEALTH SCIENCES

PHR: Malaria parasite infections and disease continue to cause considerable morbidity and mortality in Malawi. This research will ascertain why some existing malaria control practices have become less effective in reducing contact with the mosquito vector and in decreasing the incidence of malaria disease. A new anti-malaria vaccine for children and bed nets with new compounds will be evaluated for their ability to reduce disease risk.

PI_NAMEs: MATHANGA, DON P (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Africa;Africa South of the Sahara;Age Distribution;Anopheles Genus;Anti-malarials;Antiparasitic Agents;Area;awake;Beds;Behavior;Behavioral;Bite;Cessation of life;Child;Childhood;Clinical;cohort;Collaborations;Complement;Country;Culicidae;Data;Disease;disorder risk;Ecology;Effectiveness;Epidemiology;exposed human population;Future;Goals;Health;Household;Human;Immunity;Immunization Programs;implementation study;improved;Incidence;Infection;infection risk;Insecticide Resistance;Insecticides;insight;Intervention;Investigation;Life Cycle Stages;Malaria;malaria infection;Malaria prevention;malaria transmission;Malaria Vaccines;Malawi;Methods;Morbidity - disease rate;mortality;novel;novel strategies;Outcome Measure;Parasites;Parasitic infection;Parasitology;Pathway interactions;Pattern;Persons;Phase;Pilot Projects;Plasmodium;Plasmodium falciparum;Plasmodium vaccine;Policies;Population;Positioning Attribute;Poverty;Prevalence;prevent;Prevention;programs;prospective;public health intervention;Recommendation;Research;Residual state;Risk;School-Age Population;Site;skills;Surveys;Testing;Time;Training;Translational Research;transmission blocking;transmission process;Vaccination;vaccine access;vaccine trial;Vaccines;vector;vector control;Vector Ecology;vector mosquito;weather patterns

PROJECT_TITLE: Accelerating malaria prevention through enhanced analysis of transmission and RTS,S vaccination in Malawi


NIH_SPENDING_CATS: Immunization;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PROJECT_TERMS: Acceleration;Accounting;Administrator;Agreement;Authorization documentation;Baltimore;Budgets;Collaborations;Communication;Documentation;Electronic Mail;Ensure;Equipment;Equipment and supply inventories;Expenditure;Funding;Goals;Grant;Health;health management;Health Sciences;Human Subject Research;Infectious Diseases Research;Institution;Institutional Policy;Institutional Review Boards;Interdisciplinary Study;International;Laboratories;Laws;Malaria;Malaria prevention;Malawi;Maryland;meetings;Policies;Procedures;programs;Progress Reports;Reagent;Regulation;Reporting;Research;Research Activity;Research Personnel;Research Project Grants;Role;Services;Supervision;Teleconferences;Telephone;Training;transmission process;Travel;United States National Institutes of Health;Universities;Vaccination;virtual;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Data Science;Immunization;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: MATENGENI, ALFRED  (contact)

PROJECT_TERMS: Acceleration;Adansonia;Address;Biological Assay;Biometry;Biostatistics Core;Clinical Data;Clinical Research;cloud platform;Collection;Communities;Computer software;Computers;Cross-Sectional Studies;Culicidae;Data;Data Analyses;data cleaning;Data Collection;Data Coordinating Center;data integration;data management;Data Management Resources;data quality;Data Security;Data Set;data sharing;Data Sources;data visualization;Database Management Systems;Databases;demographics;design;Detection;Electronics;Enrollment;Ensure;Entomology;Environment;Epidemiology;epidemiology study;Equipment and supply inventories;experience;Field Workers;follow-up;Geographic Information Systems;Goals;Health;Health care facility;Health Sciences;high standard;Household;Information Technology;Infrastructure;International;Laboratories;Laboratory Research;land cover;Location;Longitudinal Studies;Malaria;Malaria prevention;Malawi;Manuscripts;Mentors;Metadata;Methods;Molecular;Monitor;multiple data sources;open source;operation;power analysis;prevent;Privacy;Procedures;programs;protocol development;quality assurance;Reporting;repository;Research;Research Design;Research Personnel;resilience;Sampling;Scanning;Schedule;screening;Secure;Series;Source;Statistical Data Interpretation;Study Subject;Surveys;System;Systems Integration;Tablets;Testing;tool;Training;training data;transmission process;United States National Institutes of Health;Universities;Update;Vaccination;Visit;Visualization;Weather;Work;Writing

PROJECT_TITLE: Data Management & Biostatistics Core


NIH_SPENDING_CATS: Clinical Research;Immunization;Infectious Diseases;Malaria;Pediatric;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: COHEE, LAUREN M (contact)

PROJECT_TERMS: 10 year old;5 year old;Acceleration;acquired immunity;Age;age group;age related;aged;Area;Beds;booster vaccine;burden of illness;case control;Case/Control Studies;Child;Childhood;Clinical;clinical diagnosis;combat;Community Surveys;Data;Data Collection;density;Development;Diagnosis;Disease;Dose;early childhood;Effectiveness;Effectiveness of Interventions;Epidemiology;Evaluation;Future;Health;health data;Health Service Area;Hospitalization;Hospitals;Household;human old age (65+);implementation evaluation;implementation trial;Incidence;Individual;Infant;Infection;Insecticide Resistance;Insecticides;insight;Interruption;Intervention;Investigation;Life;Link;Malaria;Malaria Diagnosis;Malaria prevention;Malawi;Measures;Modeling;mortality;Neighborhoods;novel;Outcome;Parasites;Phase;Plasmodium falciparum;Population;Population Surveillance;Prevalence;prevent;programs;Public Health;Randomized;response;Series;Site;success;surveillance data;Surveys;Time;tool;transmission process;unvaccinated;Vaccinated;Vaccination;vaccine access;Vaccines;vector control

PROJECT_TITLE: Epidemiology


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Immunization;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

PI_NAMEs: MCCANN, ROBERT SEAN (contact)

PROJECT_TITLE: Transmission


NIH_SPENDING_CATS: Adolescent Sexual Activity;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections;Social Determinants of Health

PHR: PROJECT NARRATIVE Sexually transmitted diseases (STD) such as gonorrhea and chlamydia are common among men living with HIV and men taking pre-exposure prophylaxis. Innovative strategies for STD/HIV prevention are important for developing a comprehensive HIV response, especially in low and middle-income countries. The proposed midcareer award provides protected time to support mentorship of new investigators undertaking patient- oriented HIV prevention research, building capacity for further HIV prevention research in global settings.

PI_NAMEs: TUCKER, JOSEPH DAVID (contact)

PROGRAM_OFFICER_NAME: DEJLI, JAMAL

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Antimicrobial Resistance;Applications Grants;Area;arm;Asia;Attitude;Australia;authority;Award;Behavioral;Behavioral Research;career;China;Chinese;Chlamydia;Cities;Clinic;Clinical;Clinical Sciences;Clinical Trials;co-infection;Collaborations;Communicable Diseases;Communities;Community Developments;comparison control;condoms;Confidence Intervals;Creativeness;crowdsourcing;Data;Data Collection;Dedications;Development;disorder control;Doxycycline;Eligibility Determination;Engineering;Environment;Evaluation;experience;Faculty;Foundations;France;Future;Goals;Gonorrhea;Grant;Health Professional;high risk;high risk behavior;HIV;Hospitals;Hour;Human immunodeficiency virus test;implementation strategy;Incidence;Individual;Infrastructure;innovation;Institutionalization;Intervention;K-Series Research Career Programs;Knowledge;Lead;Leadership;Letters;Link;low and middle-income countries;Manuscripts;Medical;Medicine;men;men who have sex with men;Mentors;Mentorship;Methods;multidisciplinary;National Institute of Allergy and Infectious Disease;next generation;North Carolina;Odds Ratio;open label;patient oriented;patient oriented research;peer;Peer Review;Persons;pilot trial;Policies;Positioning Attribute;Postdoctoral Fellow;pre-exposure prophylaxis;Prevention program;Prevention Research;Prevention strategy;primary outcome;Process;Productivity;professor;programs;Prophylactic treatment;Public Health;Publications;Publishing;recruit;Research;Research Personnel;Research Project Grants;research study;Research Training;Resources;response;Risk Behaviors;Role;service delivery;Sexually Transmitted Diseases;skills;social;Social Environment;State Government;STI prevention;student mentoring;symposium;Syphilis;Talents;Testing;Time;Training;Translational Research;United States;United States National Academy of Sciences;United States National Institutes of Health;Universities;Unsafe Sex;uptake;volunteer;Work;World Health Organization;young men who have sex with men

PROJECT_TITLE: Mentoring Multidisciplinary Global HIV Patient-oriented research

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Project Narrative Flux through oxidative phosphorylation is regulated by mechanisms that are not completely understood. The proposed research will address fundamental questions on how the lipid composition of mitochondrial membrane regulates bioenergetics. Findings from these studies have implications for health and disease across multiple organ systems.

PI_NAMEs: FUNAI, KATSUHIKO  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Adipose tissue;Bioenergetics;Body System;career;career development;Disease;experimental study;Fellowship;Foundational Skills;Health;Individual;interest;Laboratories;lipidome;Lipids;Mitochondria;mitochondrial membrane;Molecular Biology;Oxidative Phosphorylation;parent grant;Postdoctoral Fellow;Research;Scientist;Series;synergism;Techniques;Universities;Utah

PROJECT_TITLE: PE In Modulation of Energy Flux Through Oxphos

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


NIH_SPENDING_CATS: Genetics;Human Genome

ORG_DEPT: PATHOLOGY

PHR: NARRATIVE  Mutations in the mitochondrial genome play an important role in a number of devastating maternally inherited diseases, as well as a number of human relevant pathologies, including cancer, sarcopenia, and neurodegener- ation, but the cellular mechanisms that give rise to them or modify their presence are poorly understood. This project is designed to take advantage of cutting edge technologies to test fundamental hypotheses involving what cellular mechanisms modify their presence. The end result will be a better understanding of mitochondrial biology and the role of mitochondrial mutation in human diseases.

PI_NAMEs: KENNEDY, SCOTT ROBERT (contact)

PROJECT_TERMS: Accounting;Animal Model;Area;base editing;Biochemical;Biology;Cells;Deamination;design;Development;Disease;disease model;driver mutation;Electron Transport;experimental study;Frequencies;genetic manipulation;Genome;Germ Lines;Health;Hereditary Disease;heteroplasmy;Human;human disease;in vitro Assay;Induced Mutation;Intervention;Link;Malignant Neoplasms;Methods;Mitochondria;Mitochondrial DNA;mitochondrial DNA mutation;mitochondrial genome;Molecular;Mus;Mutagenesis;Mutation;Nerve Degeneration;Organism;Oxidative Phosphorylation;Pathology;Pathway interactions;Phenotype;Play;Process;Quality Control;Regulation;Role;sarcopenia;single cell ATAC-seq;Single Nucleotide Polymorphism;Site;small molecule;Technology;Testing;Tissues;Variant;Vertebrates;Work

PROJECT_TITLE: Understanding the regulation of mtDNA heteroplasmy and integrity

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: FORT WORTH

ORG_DEPT: BIOLOGY

ORG_NAME: TEXAS CHRISTIAN UNIVERSITY

PHR: The studies proposed in this application will facilitate a determination of the mechanisms necessary for inducing protective immune responses against cryptococcosis; a disease that is responsible for significant morbidity and mortality among AIDS patients and other immune compromised individuals.

PI_NAMEs: WORMLEY, FLOYD L. (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;antimicrobial;B-Lymphocytes;Biological Models;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Count;Cell Separation;Cells;Cessation of life;Cryptococcosis;Cryptococcus;Cryptococcus neoformans;Cryptococcus neoformans infection;Dendritic Cells;design;Development;Disease;Effector Cell;Engineering;Exhibits;Foundations;Immune;Immune response;Immunity;Immunization;Immunize;Immunocompetent;immunodeficiency;Immunologic Memory;Immunologics;Immunotherapy;Individual;Infection;Interferon Type II;Interferons;Laboratories;Life;Lung;Macrophage;Mediating;Meningoencephalitis;Molecular;Morbidity - disease rate;mortality;mouse model;Mus;Natural Killer Cells;neutrophil;Patients;Phase;Publishing;Resolution;response;Role;Secondary to;T cell response;Testing;vaccination strategy;Vaccine Design;vaccine strategy;Vaccines;XCR1 gene;Yeasts

PROJECT_TITLE: Induction of Protective Immune Responses Against C. neoformans in Immune Compromised Hosts

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


ORG_CITY: BAMAKO

ORG_COUNTRY: MALI

ORG_FIPS: ML

ORG_NAME: UNIV OF SCIENCES, TECH & TECH OF BAMAKO

PHR: Project Narrative: Sub-Saharan Africa region continues to bear the brunt of the global malaria burden despite wide deployment of control interventions. This multidisciplinary program will contribute to improve our understanding of the changing malaria epidemiology and transmission in relation with control interventions. We will developpe, evaluate and optimize ongoing malaria control strategies to produce maximum impact on transmission interruption and elimination through implementation research. We will characterize critical barriers related to changing epidemiological patterns, drug and insecticide resistance to develop adaptive evidence-based interventions to meet the evolving needs of control programs.

PI_NAMEs: DOUMBIA, SEYDOU  (contact)

PROJECT_TERMS: Accounting;Address;Africa;Africa South of the Sahara;Anopheles Genus;Anti-malarials;Area;Artemisinins;Beds;Behavior;Binding;Cessation of life;Chemoprevention;Collaborations;Combined Modality Therapy;Disease;Drug resistance;Dryness;Ecology;empowerment;Entomology;Environment;Epidemiology;epidemiology study;evidence base;Evidence based intervention;field study;Genetic;Genomics;Genotype;Geographic Distribution;Goals;Guidelines;Health;Human;Human Genetics;Immune response;Immunogenetics;Immunogenomics;Immunology;implementation research;improved;Incidence;Infection;Insecticide Resistance;Insecticides;International;Interruption;Intervention;Irrigation;Laboratory Study;Link;Longitudinal cohort study;Malaria;malaria infection;malaria transmission;Mali;multidisciplinary;N-methylchlorphentermine;next generation;Niger;Parasites;Pattern;peri-urban;Pharmacotherapy;Policies;Population;Pregnant Women;Prevalence;programs;Prospective Studies;Rain;Research;Research Personnel;Residual state;response;Rural;Sahara;Scientist;Seasons;Site;transmission process;uptake;urban area;urban setting;vector;Vector Ecology;vector mosquito;vector transmission;Withdrawal

PROJECT_TITLE: Multidisciplinary Implementation Research for malaria control and elimination in West Africa


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Address;Africa;authority;Basic Science;Communication;Communities;Country;design;Ecology;Electronics;Ensure;Epidemiology;Funding;Goals;Guidelines;health goals;human subject;Immunology;implementation research;Individual;Institution;Institutional Review Boards;inter-institutional;Interdisciplinary Study;International;Laboratories;Logistics;Malaria;malaria transmission;Mali;meetings;member;multidisciplinary;National Institute of Allergy and Infectious Disease;Office Management;Online Systems;Pathogenesis;Postdoctoral Fellow;Public Health;Reporting;Research;Research Personnel;Research Project Grants;Research Support;Research Training;Science;Services;Site;Site Visit;success;symposium;synergism;timeline;transmission process;United States National Institutes of Health;Universities;vector;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Dissemination and Implementation Research;Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PI_NAMEs: SHAFFER, JEFFREY G (contact)

PROJECT_TERMS: Address;Africa;Bioinformatics;Biometry;Biostatistical Methods;Common Data Element;Communities;Complex;Country;Data;Data Analyses;Data Collection;data harmonization;data integration;data integrity;data management;Data Management Resources;Data Science;data sharing;Data Sources;data submission;data visualization;design;Development;Ensure;Goals;Group Meetings;Human Resources;implementation research;Individual;Information Systems;Infrastructure;innovation;International;international center;Lead;Malaria;Metadata;Modernization;Monitor;multidisciplinary;multimodal data;multimodality;Population;Preparation;Procedures;Protocols documentation;Publications;Research;Research Design;Research Personnel;Research Project Grants;Resource-limited setting;Sampling;Science;sharing platform;Site;sound;Standardization;Statistical Data Interpretation;Statistical Methods;System;Systems Analysis;technology/technique;Testing;Time;Training;Training Programs;United States National Institutes of Health;Universities;user-friendly;Visualization;working group


NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: TOURE, MAHAMOUDOU  (contact)

PROJECT_TERMS: Adult;Africa;Africa South of the Sahara;Age;age related;Anopheles Genus;Area;Automobile Driving;burden of illness;Chemoprevention;Child;Clinical;cohort;Collaborations;Country;Data;Disease;Dryness;Ecosystem;Epidemiology;Exposure to;Fever;Genetic;Geographic Distribution;Goals;Growth;Guidelines;Health care facility;Human;Immune response;Immunity;Immunogenetics;implementation research;improved;Incidence;Individual;Infection;insight;Interruption;Intervention;Irrigation;Knowledge;Link;Longitudinal Studies;Malaria;malaria infection;malaria transmission;Mali;Measures;multidisciplinary;Niger;novel strategies;Outcome;Parasitemia;Parasites;Pattern;peri-urban;Plasmodium falciparum;population movement;Prevalence;programs;Research Personnel;Residual state;response;Risk;Risk Assessment;Risk Factors;rural area;rural setting;scale up;Schools;Seasons;Site;Solid;Source;Surveys;Training;transmission process;urban area;urban setting;vector;Vector Ecology;vector mosquito

PROJECT_TITLE: Malaria Epidemiology


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Malaria;Prevention;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PI_NAMEs: SOGOBA, NAFOMON  (contact)

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Africa;African;Agriculture;Alien;Anopheles gambiae;Anopheles Genus;anthropogenesis;Area;Behavior;Bite;Blood;Breeding;burden of illness;Capital;Cities;Complex;Country;Culicidae;Data;Diagnosis;Dimensions;Disease;Drug Metabolic Detoxication;Dryness;Ecosystem;Elements;Environment;environmental change;Enzymes;Epidemiology;Falciparum Malaria;feeding;Food;Future;Garbage;Genes;Goals;Habitats;Health care facility;holistic approach;Human;implementation research;Insecticide Resistance;Insecticides;Intervention;Invaded;Low Prevalence;Malaria;malaria mosquito;malaria transmission;Mali;Mediating;Metabolic;Molecular;Monitor;multidisciplinary;Mutation;Niger;novel;Parasites;peri-urban;Phenotype;Plants;Population;population survey;pressure;Prevalence;prevent;Productivity;programs;Public Health;pyrethroid;Rain;Reporting;Research;Residual state;resilience;Resistance;resistance mechanism;resistance mutation;Resistance profile;Rest;Rural;rural area;rural setting;scale up;Seasons;Site;socioeconomics;Source;sugar;tool;transmission process;United States National Institutes of Health;urban area;urban setting;vector;vector competence;vector control;Vector Ecology;vector mosquito;vector transmission;wasting;Work

PROJECT_TITLE: Malaria Vector ecology and transmission


ORG_CITY: BALTIMORE

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE The theme of this Southern and Central Africa International Center of Excellence for Malaria Research renewal application is to harness innovation to transform malaria surveillance into key interventions, derived from the World Health Organization’s Global Technical Strategy for Malaria 2016–2030. These innovative approaches will include the use of crowd-sourced data, volatilomics, machine learning forecasting models, data visualization tools at small spatial scales for local use, and periodic serological surveillance using residual blood specimens. By harnessing innovation and exploring novel data streams, malaria metrics, analytical methods, surveillance tools, and their applications to fill existing knowledge gaps and inform strategies, we hope to transform malaria surveillance into key interventions in collaboration with the Zambian National Malaria Elimination Programme, the President’s Malaria Initiative, and other partners to achieve national and regional malaria control and elimination goals.

PI_NAMEs: MOSS, WILLIAM J (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;analytical method;Anopheles Genus;Applied Research;Area;Automobile Driving;Bite;Blood specimen;Central Africa;Chronic;climate change;Clinical;Collaborations;Country;crowdsourcing;Data;Data Sources;data streams;data visualization;Decision Making;Detection;Diagnostic tests;Effectiveness;Epidemiology;Funding;Goals;improved;Incidence;Infection;innovation;Insecticides;Institution;Interdisciplinary Study;international center;Intervention;Investigation;Investments;Knowledge;Lead;Learning;Machine Learning;Malaria;malaria transmission;Measures;Modeling;Molecular;Monitor;novel;novel strategies;Parasites;Pattern;peri-urban;Periodicals;population movement;Prevalence;programs;Rapid diagnostics;Research;Research Institute;Research Project Grants;Residual state;Risk;Role;serosurveillance;Southern Africa;System;tool;Translating;transmission process;Tropical Disease;Trust;United States;urban setting;vector;Vector Ecology;Vision;Visualization software;Work;World Health Organization;Zambia

PROJECT_TITLE: Harnessing Innovation to Transform Malaria Surveillance into Key Interventions Across Transmission Settings in Zambia


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Area;Central Africa;Collaborations;Communication;Computer Models;Data Analytics;data management;data modeling;Educational workshop;Ensure;Epidemiology;experience;financial relationship;Foundations;Goals;innovation;Institution;international center;Intervention;Leadership;Malaria;meetings;National Institute of Allergy and Infectious Disease;Occupational activity of managing finances;Performance;programs;Reporting;Research;Research Activity;Research Institute;Resources;Site;Southern Africa;success;timeline;transmission process;Tropical Disease;Trust;Work;Zambia


NIH_SPENDING_CATS: Infectious Diseases;Malaria;Networking and Information Technology R&D (NITRD);Rare Diseases;Vector-Borne Diseases

PI_NAMEs: HACKMAN, ANDRE  (contact)

PROJECT_TERMS: Central Africa;Collaborations;collaborative environment;Computer software;Data;Data Collection;data integration;data management;data sharing;Databases;design;Development;Educational workshop;electronic data;empowerment;Field Reports;field study;genomic data;Genomics;Goals;Human Resources;Information Technology;Infrastructure;innovation;Institution;Intervention;Laboratory Study;Learning;Maintenance;Malaria;meetings;Mission;mobile application;multidisciplinary;open data;Personnel Management;programs;Quality Control;Reproducibility;Research;Research Design;Site;Southern Africa;success;Training;transmission process;Tropical Disease;Trust;Zambia

PROJECT_TITLE: Data Management Core


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vector-Borne Diseases

PI_NAMEs: IPPOLITO, MATTHEW MICHAEL (contact)

PROJECT_TERMS: Address;Africa South of the Sahara;analytical method;Anti-malarials;Area;Artificial Intelligence;Automobile Driving;Behavior;Behavioral;Biological Factors;Caring;Case Management;Central Africa;climate change;clinical care;Collaborations;combat;Communities;computerized tools;Computing Methodologies;Country;Data;Data Analytics;data pipeline;Data Set;data streams;data tools;Development;Drug resistance;Environment;Epidemiology;evidence base;Failure;Genomics;Genotype;Health care facility;Health system;Hospitalized Child;Household;Human;improved;Infection;innovation;Insecticide Resistance;Insecticides;insight;Intervention;Link;Location;Longitudinal cohort;Machine Learning;Malaria;malaria transmission;Maps;mathematical model;Measurement;Measures;mobile computing;Molecular;molecular marker;Morbidity - disease rate;mortality;Movement;movement analysis;novel;Parasites;Pattern;peri-urban;Population;Positioning Attribute;programs;Research;Residual state;Risk;Risk Factors;Southern Africa;spatiotemporal;surveillance data;Surveys;System;Testing;tool;transmission process;Travel;urban setting;Urbanization;vector;Work;World Health Organization;Zambia

PROJECT_TITLE: Development and Application of Innovative Malaria Surveillance Data Streams and Tools in Three Transmission Settings in Zambia


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

PROJECT_TERMS: Address;Africa South of the Sahara;Anopheles Genus;Area;Beds;Behavior;Behavioral;Bite;Blood;Blood specimen;Case Management;Central Africa;Chemicals;Child;Clinical;Collection;Country;Coupled;Culicidae;Data;data dashboard;data visualization;Decision Making;design;Detection;Development;Disease Outbreaks;Environment;Epidemiology;Foundations;Genotype;Health care facility;high risk;Household;Human;Human Characteristics;Individual;innovation;Insecticides;international center;Intervention;Investigation;Knowledge;Link;Malaria;malaria transmission;Methods;Molecular;Monitor;mortality;novel;Parasites;Pattern;peri-urban;Plasmodium falciparum;programs;rapid detection;rapid technique;Reporting;Research;Research Design;Research Infrastructure;Residual state;Risk;Risk Behaviors;risk mitigation;Rural;rural dwellers;rural environment;Rural Health;Seasons;serosurveillance;Site;Southern Africa;spatiotemporal;Surveillance Methods;surveillance strategy;Surveys;System;Testing;Time;tool;transmission process;urban setting;vector;vector control;Vector Ecology;vector mosquito;Zambia

PROJECT_TITLE: Human and Vector Drivers of Transmission and Enhanced Surveillance for Early Outbreak Detection and Monitoring Progress Toward Elimination


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Nanotechnology

ORG_DEPT: ENGINEERING (ALL TYPES)

PHR: PROJECT NARRATIVE HIV can develop resistance to drugs, which leads to increased viral load that harms patients and increases HIV transmission. Identifying drug resistance requires identifying patients who have high viral load and testing virus for mutations known to cause drug resistance. We will develop a test that rapidly tests for viral load, and for patients failing therapy, tests their virus for drug resistance mutations.

PI_NAMEs: LUTZ, BARRY RYAN (contact)

PROGRAM_OFFICER_NAME: CRAWFORD, KEITH W

PROJECT_TERMS: Address;Adherence;Algorithms;Biological Assay;Black Box;Chemistry;Clinic;Clinical Management;cost;Counseling;COVID-19 detection;COVID-19 test;Data;Data Analyses;data analysis pipeline;Detection;Diagnostic Reagent Kits;Drug resistance;Effectiveness;Eligibility Determination;Enzymes;experience;Failure;FDA Emergency Use Authorization;Fluorescence;Frequencies;Gene Amplification;Genes;Goals;Heating;helicase;HIV;HIV drug resistance;HIV Long Terminal Repeat;Hospitals;Human immunodeficiency virus test;innovation;instrumentation;Intervention;Intuition;Kenya;Libraries;Licensing;Location;Long Terminal Repeats;Longevity;Magnetism;Marketing;Methods;Monitor;Mutation;nanopore;new technology;nucleic acid detection;Patients;Persons;Pharmaceutical Preparations;Plasma;Point Mutation;point of care;Preparation;prevent;Procedures;Production;Protein Engineering;Proteins;prototype;Qualifying;Reader;Reagent;Recipe;Recommendation;Reflex action;Regimen;Reporting;Resistance;Resistance development;resistance mutation;Resources;Risk;RNA;Running;Sampling;Signal Transduction;Site;South Africa;Technology;Testing;thermostability;transmission process;Treatment Failure;Viral Load result;Viremia;Virus;virus testing;Visit;Whole Blood;Work;World Health Organization

PROJECT_TITLE: V-OLA point-of-care HIV viral load monitoring and drug resistance testing

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: PROGRAM NARRATIVE In recent years, the global incidence of malaria has been rising, primarily driven by a subset of high-burden countries in sub-Saharan Africa, including Cameroon. This program aims to address this urgent problem by conducting comprehensive research on humans, vectors, and parasites using innovative approaches and technologies in selected study sites representing all strata of malaria transmission. The proposed two interrelated projects will systematically investigate the fundamental mechanisms underlying persistent high-level malaria transmission to inform the national malaria control program to develop effective malaria control strategies in Cameroon.

PI_NAMEs: CUI, LIWANG  (contact)

PROJECT_TERMS: Acute;Address;Affect;Africa;Africa South of the Sahara;African;Anopheles Genus;Anti-malarial drug resistance;Artemisinins;Back;Beds;Behavior;Bioinformatics;Biology;Biostatistics Core;Bite;Cameroon;Case Management;Central Africa;Cessation of life;Chemoprevention;Chemopreventive Agent;Child;Climate;Collaborations;Combined Modality Therapy;Complex;Country;Culicidae;Data;data management;design;Disease;disease transmission;Drug resistance;Ecology;Effectiveness;environmental change;Epidemiology;Evolution;Exhibits;experience;experimental study;feeding;Genomics;Geography;Goals;Heterogeneity;Human;improved;Incidence;innovation;innovative technologies;Insecticide Resistance;Insecticides;insight;International;international center;Intervention;Longitudinal cohort study;Malaria;malaria transmission;Measures;Monitor;Multi-Drug Resistance;Parasite resistance;Parasites;Pattern;Plasmodium falciparum;Play;Population;Population Biology;Pregnant Women;Preventive measure;programs;Reporting;Research;Research Personnel;Residual state;response;Role;Seasons;Shapes;Site;System;Technology;Therapeutic;transmission process;trend;vector;vector mosquito;Vectorial capacity;Vulnerable Populations

PROJECT_TITLE: Unraveling the Drivers of Persistent Malaria Transmission in Cameroon: A Systems Approach (REDIAL)