NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: NEW HAVEN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: The proposed research will study the important molecular pathways that regulate the metastasis of the most common type of ovarian cancer. Our findings will facilitate the discovery of new therapeutic targets for treating metastatic ovarian cancer. Therefore, our research is relevant to NIH’s mission that pertains to advancing fundamental knowledge to help improve the treatment of ovarian cancer.

PI_NAMEs: YANG-HARTWICH, YANG  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: 3-Dimensional;Adhesions;Animals;antitumor effect;apoAI regulatory protein-1;Automobile Driving;Bioinformatics;Biological;Biological Assay;brca gene;cancer cell;Cancer cell line;cancer initiation;Cancer Patient;cancer stem cell;Carcinoma;Carcinoma in Situ;Cell Adhesion;cell motility;Cell Physiology;cell transformation;Cells;Clinical;Data;Data Set;Development;Diagnosis;differential expression;Disease;Disease-Free Survival;Distal;effective therapy;Epithelial Cells;Family;Family member;Funding;Genes;Genetic;genetic signature;Genetic Transcription;Genetically Engineered Mouse;Greater sac of peritoneum;Human;improved;In Situ;In Vitro;in vivo;Induced Mutation;inhibitor;insight;Interruption;intraperitoneal;knock-down;Knowledge;Lesion;Malignant neoplasm of ovary;Malignant Neoplasms;Mammalian Oviducts;metastatic process;migration;Mission;Modeling;Molecular;mouse model;Mus;Mutation;Neoplasm Metastasis;neoplastic cell;new therapeutic target;NF1 tumor suppressor;novel;Organoids;Outcome;ovarian neoplasm;Ovarian Serous Adenocarcinoma;Ovary;Pathway Analysis;Pathway interactions;Patients;Pattern;Platinum;Population;prevent;Prognosis;promoter;prostate cancer model;protein expression;Proteins;Recurrence;Research;Resistance;Role;Sampling;Serous;single-cell RNA sequencing;small molecule;small molecule inhibitor;Source;System;Testing;The Cancer Genome Atlas;therapeutic target;Tissue Stains;TP53 gene;transcription factor;tumor;tumor initiation;tumor progression;Tumor stage;Tumor Suppressor Genes;Tumor-Associated Process;United States National Institutes of Health;Woman;women's treatment

PROJECT_TITLE: Uncovering the Mechanisms of Metastasis in Fallopian Tube-Originated Ovarian Cancer

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ADMINISTERING_IC: HD

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Pediatric;Pediatric - AIDS;Precision Medicine;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

ORG_STATE: MA

PI_NAMEs: LICHTERFELD, MATHIAS  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Adolescent;antiretroviral therapy;Architecture;Atlases;Autologous;Binding;Biotechnology;Birth;Botswana;Cells;Centromere;Child;Chromatin;chromosomal location;Chromosome 19;Clinical Trials Design;clinically significant;Country;COVID-19 vaccination;curative treatments;Data;design;Development;Disease;Early treatment;Evolution;Frequencies;Future;Genes;Genetic Transcription;Heterochromatin;HIV;HIV vaccine;HIV-1;Human Genome;Immune;immune activation;Immune response;immunogenicity;Immunologics;improved;Infant;infant infection;Infection;integration site;Length;Licensing;Location;Lopinavir/Ritonavir;Mass Vaccinations;Mediating;Memory;Memory B-Lymphocyte;Messenger RNA;Methodology;Modeling;neonatal infection;next generation sequencing;novel;novel strategies;patient population;Patients;Pattern;pediatric human immunodeficiency virus;pediatric patients;permissiveness;personalized therapeutic;Persons;Pharmaceutical Preparations;Positioning Attribute;precision medicine;Predisposition;Pregnant Women;Probability;Provirus Integration;Proviruses;Research;Resources;response;RNA;RNA vaccination;RNA vaccine;Satellite DNA;sequencing platform;Signal Transduction;Structure;T cell response;Techniques;technology platform;Teenagers;Testing;theories;Therapeutic;therapeutic vaccine;Vaccination;Vaccine Design;vaccine immunogenicity;Vaccine Research;Vaccine Therapy;Vaccines;Viral;Viral reservoir;Viremia;Work;zinc finger nuclease

PROJECT_TITLE: Pioneering Precision Medicine Approaches for Immune Control of Pediatric HIV-1 Infection


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Immunotherapy;Neuroblastoma;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: PROJECT NARRATIVE The treatment of pediatric cancers has remained largely unchanged in decades, relying primarily on aggressive cytotoxic chemotherapy and radiation, however, these therapies have debilitating long-term consequences. We will use new computational methodologies applied to large preclinical screening data from cancer cell lines and patient -omics datasets to investigate unmutated genes as potential drug targets in pediatric cancers (non-oncogene dependencies). We will perform the requisite downstream experimental work, including studying drug combinations and resistance mechanisms, necessary to motivate the clinical translation of our findings.

PI_NAMEs: GEELEHER, PAUL  (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: actionable mutation;Address;Adult;Affect;Antineoplastic Agents;Biological Assay;Biology;Bone neoplasms;Cancer cell line;cancer genome;cancer immunotherapy;Cancer Patient;cancer subtypes;cancer therapy;Cause of Death;Cell Line;Cells;chemotherapy;Chemotherapy and/or radiation;Child;Childhood;Childhood Cancer Treatment;Childhood Solid Neoplasm;Clinic;Clinical;Clinical Research;clinical translation;clinically actionable;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Computing Methodologies;CRISPR screen;Cytotoxic Chemotherapy;Data;Data Set;Dependence;Dimensions;Disease;disorder subtype;Drug Combinations;Drug resistance;Drug Screening;Drug Synergism;Drug Targeting;Encyclopedias;Ewings sarcoma;Future;Gene Expression;Genes;Genome;genome sequencing;Genomics;Goals;Heterogeneity;high risk;high throughput screening;Immunotherapy;improved;In Vitro;in vivo;Knock-out;Machine Learning;Malignant Childhood Neoplasm;Malignant Neoplasms;Maps;Methodology;Methods;Methylation;mouse model;Mutation;Nature;neoantigens;Neuroblastoma;neuroblastoma cell;novel;novel drug combination;novel therapeutic intervention;novel therapeutics;Patient Care;patient derived xenograft model;Patients;Pediatric Neoplasm;Pharmaceutical Preparations;Poly(ADP-ribose) Polymerase Inhibitor;pre-clinical;precision medicine;preclinical study;programs;rapid growth;Relapse;Research;Research Personnel;Resistance;resistance mechanism;resistance mutation;Resource Sharing;response;Saint Jude Children's Research Hospital;screening;Somatic Mutation;standard of care;synergism;targeted cancer therapy;Technology;Testing;Therapeutic;tool;transcriptomics;tumor;tumor heterogeneity;Tumor Subtype;whole genome;Work

PROJECT_TITLE: Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Dementia;Genetic Testing;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety;Precision Medicine;Prevention;Social Determinants of Health

ORG_CITY: RESTON

ORG_NAME: PARABON NANOLABS, INC.

ORG_STATE: VA

PHR: PROJECT NARRATIVE Alzheimer’s Disease (AD) affects millions of Americans, yet there are no treatments that significantly slow disease progression once symptoms manifest, making early intervention crucial to reduce the individual and societal burden of this disease. Existing genetic risk prediction models are limited to individuals of European descent, and this proposal seeks to create a truly cross-ancestry model that can predict any individual’s AD risk, which will be made widely available as a direct-to-consumer genetic test. It will enable early intervention and life planning for at-risk individuals and allow researchers to maximize the probability of detecting treatment effects in clinical trials by assessing patients’ underlying disease risk.

PI_NAMEs: GREYTAK, ELLEN MCRAE (contact)

PROGRAM_OFFICER_NAME: FENG, LI REBEKAH

PROJECT_TERMS: Address;Adult;Affect;Age;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;American;analysis pipeline;burden of illness;Businesses;clinical application;Clinical Trials;clinically significant;Cognition;Cognitive;commercial application;commercialization;Communication;community engagement;community setting;Computer software;Cyclophosphamide;Data Set;Databases;deep learning;Dementia;Development;Discrimination;Disease;disease phenotype;Disease Progression;disorder risk;DNA analysis;Early Diagnosis;Early Intervention;Early treatment;Educational Materials;effective therapy;Emotional;Enrollment;Ensure;Equity;European;European ancestry;Evaluation;Event;Exclusion;feature selection;Forensic Medicine;Foundations;Future;Genetic;Genetic Epistasis;Genetic Risk;genetic testing;genetic variant;genome analysis;Genomic medicine;Genotype;Goals;health assessment;health care disparity;healthy lifestyle;high risk;Impaired cognition;improved;Incidence;Individual;Institutional Review Boards;interactive tool;Intervention;Late Onset Alzheimer Disease;Learning;Life;Life Style;lifetime risk;Machine Learning;Manuscripts;Maps;Marketing;Measures;Medical;Methodology;Methods;middle age;mobile application;Modeling;Monitor;Nerve Degeneration;novel;novel strategies;Pathologic;Patient risk;patient stratification;Patients;Performance;Persons;Phase;Pilot Projects;polygenic risk score;Population;Population Group;predictive modeling;Preparation;prevent;Prevention;Probability;prototype;recruit;Reporting;Research Personnel;Resources;Risk;Risk Assessment;risk prediction;risk prediction model;Sampling;Sensitivity and Specificity;Services;Small Business Innovation Research Grant;socioeconomics;software infrastructure;Stratification;Study Subject;Symptoms;System;Testing;tool;Training;treatment effect;Treatment Effectiveness;underserved community;usability;Validation;whole genome;Work

PROJECT_TITLE: Novel whole-genome analysis methods for Alzheimer's risk prediction


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Health Disparities and Racial or Ethnic Minority Health Research;Hypertension;Racial and Ethnic Minority Health Research

ORG_CITY: BIRMINGHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Narrative Through the proposed study, we hope to understand how many African Americans have a particularly severe form of high blood pressure called treatment-resistant hypertension (TRH). In order to do that, we need to rule out other conditions that are not TRH, but make a person’s blood pressure high, such as not taking medications as prescribed, kidney problems, or disordered breathing while sleeping. Finally, we want to identify the role of lifestyle factors, such as diet and exercise, on this severe form of high blood pressure.

PI_NAMEs: GABRIEL, KELLEY PETTEE (contact);TANNER, RIKKI M

PROGRAM_OFFICER_NAME: KUNZ, JOHN FREDERIC

PROJECT_TERMS: Adherence;Adult;Adverse event;African American;African American population;Ambulatory Blood Pressure Monitoring;American Heart Association;Ancillary Study;Anti-Hypertensive Agents;Anti-Inflammatory Agents;Award;Blood Pressure;blood pressure control;blood pressure elevation;cardiovascular disorder risk;Chronic Kidney Failure;Clinic;Clinic Visits;Clinical;clinical diagnosis;clinical translation;comparison group;Coronary heart disease;Data;Data Collection;Diabetes Mellitus;Diagnosis;diagnostic algorithm;diet and exercise;Disparity;Enrollment;Evaluation;Funding;Future;Grant;Health;Healthcare;Heavy Drinking;High Prevalence;high risk;Hyperaldosteronism;Hypertension;improved;Individual;Infrastructure;Intake;Jackson Heart Study;Kidney;Kidney Diseases;Knowledge;lifestyle factors;Measurement;medication compliance;mortality;Obesity;Obstructive Sleep Apnea;Organ;Outcome;overtreatment;Parents;Participant;Patient Recruitments;Patients;Pattern;Persons;Pharmaceutical Preparations;Phenotype;physical inactivity;Population;Prevalence;Prognosis;Prospective cohort;Prospective, cohort study;racial disparity;racial population;recruit;Regimen;research clinical testing;Research Personnel;Resistant Hypertension;Resources;Respiration Disorders;Risk;Risk Factors;Role;screening;Secondary to;Sleep;Sodium;translational study;treatment response;unhealthy lifestyle;Urinalysis;Visit;wasting

PROJECT_TITLE: Determining true versus apparent treatment-resistant hypertension among African Americans in the Jackson Heart Study

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Cardiovascular;Heart Disease;Hematology;Lung;Physical Injury - Accidents and Adverse Effects;Pulmonary Hypertension

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Inhalation of toxic chemicals often causes late development of high blood pressures within the lungs for unclear reasons, leading to significant breathing difficulties, heart damage, and sometimes even death. In this project we will study two chemicals that injure the lungs after direct inhalation, but where only one of those chemicals causes late-onset high blood pressures in the lungs, while the other results in normally recovered lungs within days. We will investigate a possible reason for developing such high lung blood pressures, by studying the abnormal healing of the blood vessels that support the lungs. The findings of this application will improve our understanding of late-onset blood vessel problems after chemical inhalation, and will lead to the new medication testing in the future.

PI_NAMEs: VERESS, LIVIA AGNES (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;acute symptom;airway obstruction;Aorta;Biological Assay;Blood coagulation;Blood Pressure;Blood Vessels;Breathing;Calcium;Cardiac;Cardiac Function Study;Cardiac Myocytes;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;Cell Culture Techniques;Cessation of life;Chemicals;Chlorine;chlorine gas;Chronic;Chronic Bronchitis;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Chronic pulmonary heart disease;Coagulation Process;Data;Development;Dextrans;Disease;Dose;Echocardiography;Edema;Endothelial Cells;Endothelin-1;Endothelium;Epithelium;Evaluation;Event;Exposure to;Failure;Female;Fibrin;Fibrosis;Functional disorder;Future;Gene Expression Profile;Heart;heart damage;Heart failure;Heart Rate;hemodynamics;Histology;Histopathology;Hour;Human;Hypertension;Hypertrophy;Impaired healing;improved;In Vitro;in vivo;Inhalation;Inhalation Exposure;inhibitor;Injury;injury and repair;interest;Lethal Dose 50;Lung;male;Measurement;Measures;Medical;Modeling;Molecular;molecular marker;Morbidity - disease rate;Muscle Cells;Mustard Gas;Myocardial dysfunction;Nervous System;novel therapeutics;Organ;Oxygen;Pathogenesis;Pathway Analysis;Pathway interactions;Permeability;Persons;Pharmaceutical Preparations;Phase;Poison;prevent;protein expression;Proteomics;Pulmonary Fibrosis;Pulmonary Hypertension;Pulmonary vessels;Pulse Oximetry;Quality of life;Rattus;Recovery;Resistance;Signal Transduction;Smooth Muscle Myocytes;Sprague-Dawley Rats;Structure;Survivors;Syndrome;targeted treatment;Techniques;Tenascin;Testing;therapeutic development;Thrombophilia;Thrombosis;Time;transcriptome sequencing;Vascular Diseases;Vascular Endothelial Growth Factors;vascular injury;Ventricular Dysfunction;Veterans;Weight;Western Blotting

PROJECT_TITLE: Vascular injury and repair predict divergent late onset cardiovascular morbidities after chlorine and sulfur mustard exposure


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: SAN FRANCISCO

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The interactive scientific visualization software tools we develop directly address many of the critical challenges researchers face as they discover, analyze, and chronicle the major biological processes inherent in life and human disease. Our software enables spatially complex experimental data that often varies over time to be visualized and analyzed and, thus, directly leads to a deeper understanding of important principles in biomedicine. We strive to promote the application of interactive 3D visualization and analysis techniques to critically important cutting-edge problems in structural and computational biology, and to provide insight into molecular and cellular function that can be directly applied to problems relevant to both translational biomedical research and precision medicine.

PI_NAMEs: FERRIN, THOMAS E (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 3-Dimensional;Abate;Address;Advanced Development;Algorithms;Amino Acid Sequence;animation;applied biomedical research;Area;Attention;base;Base Sequence;Biological;Biological Process;biological systems;Biomedical Research;Brain;Cell Physiology;Cells;Cellular Structures;Charge;Communities;Complex;complex data;Computational Biology;Computer Graphics;Computer software;Computers;Cryoelectron Microscopy;Data;Data Analyses;Data Set;density;design;Development;Disease;Docking;Documentation;Drosophila genus;Drug Design;drug development;Drug Targeting;Educational process of instructing;Electron Microscopy;Elements;experimental study;Face;Feedback;flexibility;Foundations;Funding;Goals;Growth;human disease;Image;innovation;insight;interactive tool;interactive visualization;Intuition;Journals;Knowledge;lectures;Length;Life;Lighting;Link;machine learning method;Maps;Methods;Microscopy;Modeling;Molecular;Molecular Analysis;molecular assembly/self assembly;Molecular Conformation;molecular dynamics;Molecular Machines;Molecular Structure;mouse model;movie;multi-scale modeling;multidimensional data;Mutation;next generation;Operating System;Outcome;particle;Pattern;Performance;precision medicine;Process;Production;Property;Protein Engineering;Proteins;Publications;Reading;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Role;Scientist;Sequence Alignment;Software Engineering;software repository;Software Tools;Source Code;statistics;structural biology;Structure;Talents;Techniques;technology development;Three-dimensional analysis;three-dimensional visualization;Time;timeline;Tissue imaging;Tissues;Tomogram;tomography;tool;Training;United States National Institutes of Health;virtual reality;Visualization;Visualization software;web based software;web site;Work

PROJECT_TITLE: ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale Modeling

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Aneuploidy, or an abnormal chromosome number, is a leading cause of spontaneous abortions and infertility in women and also causes diseases such as Down, Turner or Klinefelter syndromes. The object of this research is to understand how oocytes receive the correct number of chromosomes and the mechanisms of errors that lead to aneuploidy.

PI_NAMEs: MCKIM, KIM S (contact)

PROGRAM_OFFICER_NAME: MILLER, RITA K

PROJECT_TERMS: Aneuploidy;Antibodies;Binding;Caenorhabditis elegans;Centromere;centromere protein A;centromere protein C;Centrosome;chromosome number abnormality;Chromosome Segregation;Chromosomes;Complex;Congenital Abnormality;Defect;Disease;Down's Syndrome;Drosophila genus;Drosophila melanogaster;Elements;Ensure;experimental study;Female;Female infertility;Fertility;Funding;Germ Lines;Goals;Homologous Gene;Human;human female;human model;Infertility;Insecta;insight;interest;Kinesin;Kinetochores;Klinefelter's Syndrome;Lateral;Lead;Link;Mammals;Meiosis;Metaphase;Microtubules;Modeling;Mus;mutant;Mutation;N-terminal;Oocytes;Organism;Orthologous Gene;Predisposition;premature;Process;Prometaphase;Prophase;Proteins;Reagent;recruit;Research;Resistance;RNA Interference;Role;segregation;Side;Spontaneous abortion;Structure;Testing;tool;Transgenes;Turner's Syndrome;Variant;Vertebral column;Work

PROJECT_TITLE: Homolog bi-orientation and segregation in oocyte acentrosomal meiosis


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Enhancer RNAs Boost MYC-Chromatin Interaction to Regulate Gene Expression and Tumorigenesis  In this proposal, we will test our hypothesis that (1) MYC is an RNA-binding protein and (2) eRNA- mediated MYC-chromatin binding is important for MYC’s transcriptional regulation and oncogenic function. Successful completion of our project will add a new dimension and novel tools to investigate MYC regulation of gene expression. Our project will also lay the foundation to develop novel strategy to target MYC in cancer.

PI_NAMEs: YANG, DA  (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Binding;Biological Assay;Bromodomains and extra-terminal domain inhibitor;ChIP-seq;Chromatin;Chromatin Interaction Analysis by Paired-End Tag Sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Data;design;Dimensions;Dimerization;DNA;DNA Binding;EMSA;Enhancers;ESR1 gene;Estrogen receptor positive;Foundations;Gene Amplification;Gene Expression;Gene Expression Regulation;Goals;GREB1 gene;Growth;In Vitro;in vivo;Invaded;Investigation;knock-down;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mediating;Molecular;MYC Family Protein;novel;novel strategies;Oncogenes;Oncogenic;overexpression;Pathologic;Physiological;Play;preference;promoter;recruit;Regulation;Regulator Genes;Reporter;Research;RNA;RNA Binding;RNA-Binding Proteins;Role;Small Interfering RNA;Technology;Testing;tool;transcription factor;Transcriptional Regulation;tumor;tumor growth;tumorigenesis

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Patient Safety;Pediatric;Pediatric Cancer;Prevention;Primary Health Care;Rare Diseases;Telehealth

ORG_CITY: WASHINGTON

ORG_NAME: GEORGETOWN UNIVERSITY

ORG_STATE: DC

PHR: Project Narrative More than 80% of childhood cancer survivors develop serious or life-threatening late effects after cancer therapy, but <20% receive recommended survivorship care offered at cancer center survivorship clinics. In a shared care model, we propose to investigate an innovative multi-level intervention consisting of: 1) patient survivorship education via telehealth with the cancer center, 2) ongoing patient-tailored education program within the electronic health record patient portal, 3) a structured interactive phone communication between the cancer center and the primary care clinic, and 4) an in-person visit with the primary care clinic for survivorship care with the goal of achieving high rates of adherence to recommended surveillance for late effects, as well as improving patient and physician knowledge and self-efficacy. If our scalable intervention demonstrates patient completion of recommended care comparable to cancer center survivorship clinics, our innovative study has the enormous potential to deliver recommended care to a larger proportion of childhood cancer survivors and reduce survivorship care disparities, while engaging patients and primary care providers to integrate survivorship care as part of overall, lifelong health maintenance.

PI_NAMEs: KADAN-LOTTICK, NINA S (contact)

PROGRAM_OFFICER_NAME: ADAMS, LYNN S

PROJECT_TERMS: acceptability and feasibility;Adherence;adherence rate;Age;arm;Black race;Cancer Center;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;chemotherapy;childhood cancer survivor;Clinic;Collaborations;Common Terminology Criteria for Adverse Events;Communication;Communities;comparison group;Confusion;Consensus;COVID-19 pandemic;Diagnosis;direct patient care;Disparity;disparity gap;Dissemination and Implementation;Education;Electronic Health Record;Eligibility Determination;Enrollment;Ensure;Explosion;follow-up;future implementation;Goals;Guidelines;Health;health disparity;Health Services;improved;individual patient;innovation;Institution;instrument;Insurance;Interactive Communication;Intervention;intervention participants;Interview;Knowledge;Late Effects;Latinx;Life;Maintenance;Malignant Childhood Neoplasm;Malignant Neoplasms;Medical Records;medical specialties;Methods;Modeling;Monitoring for Recurrence;Oncologist;Outcome;Patient Care;Patient Education;patient engagement;patient health information;patient portal;Patient-Focused Outcomes;Patients;Persons;Physicians;preference;primary care clinic;primary care provider;primary endpoint;primary outcome;Process;programs;provider-level barriers;Quality of Care;Radiation;Randomized;Randomized, Controlled Trials;Recommendation;Recurrent tumor;Resources;Rural;Sampling;Self Efficacy;Site;socioeconomic disadvantage;Spanish;Structure;Subgroup;Surveys;survivorship;Technology;telehealth;Telephone;Testing;Text Messaging;Travel;Uninsured Medical Expense;Visit;Work

PROJECT_TITLE: BRidging Information Divides and Gaps to Ensure Survivorship: the BRIDGES Randomized Controlled Trial of a Multilevel Intervention to Improve Adherence to Childhood Cancer Survivorship


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Dissemination and Implementation Research;Health Services;Prevention;Primary Health Care;Substance Misuse;Tobacco;Tobacco Smoke and Health;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: PROJECT NARRATIVE Bladder cancer is caused by smoking and continued smoking after diagnosis leads to significant and preventable morbidity and mortality. Bladder cancer patients rely principally on their urologist for medical guidance but urology providers do not frequently use evidence-based practices (EBPs) that screen patients for smoking and provide them with the necessary counseling and medications to quit. In this study, we will characterize use of smoking cessation EBPs in the urology clinic then adapt and pilot a strategy to facilitate use of these EBPs in the urology clinic for patients with bladder cancer.

PI_NAMEs: MATULEWICZ, RICHARD STEVEN (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Academic Medical Centers;Active Learning;Address;Adult;Awareness;Biometry;cancer diagnosis;Cancer Patient;cancer recurrence;Cancer Survivor;care delivery;career development;Caring;Clinic;Clinic Visits;clinical decision support;Collaborations;comorbidity;Computerized Medical Record;Counseling;Data Science;data warehouse;Development Plans;Diagnosis;Drug Prescriptions;evidence base;Evidence based practice;Evidence based treatment;Face;Familiarity;Focus Groups;Future;Goals;Guidelines;Health Services Research;Hospitals;implementation science;implementation strategy;implementation study;improved;improved outcome;innovation;Interview;K-Series Research Career Programs;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Medical;member;Memorial Sloan-Kettering Cancer Center;Mentors;Methods;Morbidity - disease rate;mortality;multidisciplinary;Newly Diagnosed;nicotine replacement;novel;Oncology;Outcome;patient screening;Patient-Focused Outcomes;Patients;Pattern;Peripheral;Pharmaceutical Preparations;Pharmacotherapy;Positioning Attribute;preservation;Prevalence;Primary Care;Process;Provider;Qualitative Methods;Qualitative Research;Quality of life;recruit;Recurrence;Research;research and development;Research Methodology;Research Personnel;Research Priority;Research Project Grants;Research Proposals;Risk;Risk Factors;Science;screening;skills;Smoke;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;support tools;Surgical Oncology;theories;Tobacco;Training;treatment strategy;United States;Urologic Oncology;Urologist;Urology;Variant;Veterans;Veterans Health Administration;Vulnerable Populations

PROJECT_TITLE: Optimizing Smoking Cessation Treatment for Patients with Bladder Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Services;Hematology;Pediatric

ORG_CITY: BLANTYRE

ORG_COUNTRY: MALAWI

ORG_FIPS: MI

ORG_NAME: MALAWI BLOOD TRANSFUSION SERVICE

ORG_ZIPCODE: xxxxxxxx

PHR: Enhancing blood Donation at Schools and Beyond: An implementation Science study Project Narrative Inadequate blood supplies in Malawi continue to prevent optimal reduction of infant, under-5, maternal mortality and HIV associated deaths. We propose to conduct critical epidemiology surveillance and hemovigilance and qualitative research to understand facilitators and motivators of blood donation and strategies for engaging youth. Using this information, we will conduct a cluster randomized clinical trial to evaluate the effectiveness of an enhanced school-based donor program to increase both initial donation and long term retention as a donor.

PI_NAMEs: HOSSEINIPOUR, MINA CHRISTINE;MBAYA, BRIDON  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Age;Anemia;Area;Behavioral Sciences;Blood;Blood Banks;Blood Donations;Blood Transfusion;Cessation of life;Characteristics;Clinical Trials;Collection;Communication;Communities;community engagement;Consolidated Framework for Implementation Research;cost effectiveness;Country;Data;data quality;Data Reporting;Databases;Death Rate;design;Discipline of obstetrics;effectiveness evaluation;effectiveness outcome;Eligibility Determination;Ensure;Epidemiologic Monitoring;Epidemiology;Evaluation;Event;expectation;experimental study;Familiarity;Focus Groups;Geographic Locations;Geography;Gifts;Goals;Grant;Health;health data;Hemorrhage;High School Student;HIV;Hospitals;Hotlines;Hybrids;Implementation readiness;implementation science;implementation strategy;improved;incentive program;Infant;Infection;information gathering;Interdisciplinary Study;Intervention;Interview;Malaria;Malawi;Maternal Mortality;Measures;meetings;Mission;Modeling;Modification;Monitor;mortality;Motivation;Performance;Phase;Policies;preference;prevent;preventable death;programs;Qualitative Evaluations;Qualitative Methods;Qualitative Research;Randomized;randomized, clinical trials;recruit;Research;Research Personnel;research study;retention rate;Risk;Role;Schools;Secondary Schools;service programs;Services;Site;social media;Students;System;Telephone;Text Messaging;Time;Transfusion;transfusion medicine;transmission process;trial design;Update;uptake;Vascular blood supply;volunteer;Youth

PROJECT_TITLE: Enhancing Blood Donation at Schools and Beyond: An Implementation Science Study


NIH_SPENDING_CATS: Cancer;Clinical Research;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Prevention;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Stomach Cancer

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Gastric cancer is significantly more common among Black, Asian, and Hispanic individuals than among whites in the US, and moreover individuals who self-identify as belonging to any one of these three minority groups are also more likely to die from this highly fatal cancer, which is generally asymptomatic until late stage when treatment is no longer effective. Most gastric cancers are caused by infection with the bacteria Helicobacter pylori (H. pylori), which is also more common among people of color than among whites, but even among all H. pylori-infected individuals, people of color are still more likely to develop and die from gastric cancer. This project seeks to understand the underlying reasons for the racial disparities to enable identification of key predictors to allow us to identify those at highest risk for gastric cancer, among whom H. pylori eradication and gastric cancer prevention are a high priority.

PI_NAMEs: EPPLEIN, MEIRA  (contact)

PROGRAM_OFFICER_NAME: LAM, TRAM K

PROJECT_TERMS: Affect;Antibiotics;Antibodies;Antibody Response;Asian population;Atrophic;Atrophic Gastritis;Bacteria;Biological;Biological Assay;Biological Markers;biomarker validation;Bismuth;black men;Black Populations;Body mass index;cancer diagnosis;Cancer Etiology;cancer risk;carcinogenicity;Cells;Characteristics;Chronic stress;Clinical Trials;cohort;Cohort Studies;Communities;cost effective;Country;Crowding;Data;Death Rate;Development;Diagnosis;Diagnostic;Diet;Disease;Disparity;ethnic minority;falls;Far East;Funding;Future;gastric cancer prevention;Genes;Goals;Helicobacter Infections;Helicobacter pylori;Helicobacter pylori induced gastric cancer;Hepatitis B Virus;Hepatitis C virus;high risk;Hispanic Populations;Household;Human Papillomavirus;Immune response;improved;Incidence;Individual;individualized prevention;Infection;Infectious Agent;Inflammation;Knowledge;Laboratory Study;Lesion;Malignant Neoplasms;malignant stomach neoplasm;Mass Screening;Mediating;men;Minority Groups;Modeling;mortality;mortality disparity;multi-ethnic;Neighborhoods;Nested Case-Control Study;Not Hispanic or Latino;novel;outcome disparities;Patients;Pattern;people of color;Pepsinogens;Persons;Population Heterogeneity;predictive tools;premalignant;Prevalence;Prevention Guidelines;Prospective cohort;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Proteins;Proton Pump Inhibitors;Race;racial difference;racial disparity;racial minority;residential segregation;Risk;Risk Factors;risk prediction;Role;Screening for Gastric Cancer;screening guidelines;Smoking;Smoking Status;social health determinants;Societies;Specimen;Stomach;Survival Rate;Time;United States;Virulence Factors;Women's Health

PROJECT_TITLE: Delineating the underlying reasons for the racial disparity in gastric cancer incidence in the United States


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Prevention;Regenerative Medicine;Wound Healing and Care

ORG_NAME: SCHEPENS EYE RESEARCH INSTITUTE

PHR: NARRATIVE Currently, there are no effective tools for preventing or treating corneal scarring, which is a complication that potentially occurs with ocular injury, trauma, and/or surgery, and may result in decreased quality of life and possibly blindness. Extracellular vesicles (EVs), which contain cargo (e.g., RNA, protein, and lipids), are released by the corneal cells, and those released by the corneal epithelium can trigger myofibroblast differentiation, which will cause scarring and diminish vision if they persist. In this proposal, we will identify the EV-subset that is vital for corneal stromal activation and scarring, so that we may move forward with the development of novel therapies for the prevention and treatment of corneal scarring.

PI_NAMEs: YEUNG, VINCENT  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: 3-Dimensional;Actins;Automobile Driving;Biodistribution;Biogenesis;Biological Process;Biology;biophysical properties;Biophysics;Blindness;Cell Communication;Cell Physiology;Cells;Cicatrix;Coculture Techniques;Complication;Cornea;corneal epithelium;corneal scar;Cytosol;Data;Development;effective therapy;Elements;Environment;Epithelial Cells;exosome;extracellular;Extracellular Matrix;extracellular vesicles;Eye Injuries;Fibroblasts;Fibrosis;Genes;healing;Homeostasis;Human;In Vitro;in vitro Model;in vivo;insight;Investigation;Knock-out;Lipids;Mediating;Metabolic;Modeling;Molecular;Mus;Myofibroblast;Natural regeneration;novel;novel therapeutics;Operative Surgical Procedures;paracrine;Phenotype;prevent;Prevention;Prevention therapy;Production;Property;Proteins;Proteome;Proteomics;Public Health;Quality of life;Reporting;Risk Reduction;RNA;Small Interfering RNA;Stromal Cells;Testing;three dimensional cell culture;three-dimensional modeling;tool;transcriptome sequencing;transforming growth factor beta3;Transforming Growth Factors;Trauma;vector;Visual impairment;wound;wound healing

PROJECT_TITLE: Mechanisms of corneal stromal activation during regeneration and fibrosis by exosomes


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Project Narrative Proton and ion therapy have the potential to provide effective tumor control in cancer patients while minimizing the side effects of radiotherapy. Optimal treatment requires accurate knowledge of the biological effectiveness of the beams, which is directly impacted by the patterns of ionization produced in the patient. In this proposal, we develop and evaluate innovative methods to use ionization detail for planning particle beam therapy.

PI_NAMEs: FADDEGON, BRUCE  (contact);JAEKEL, OLIVER ;MAO, JIAN-HUA ;SCHULTE, REINHARD W.

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;absorption;Address;Aerobic;Algorithms;Anatomy;Animals;Artificial Intelligence;Biological;Biological Models;Biometry;cancer cell;Cancer Patient;Cancerous;Carbon;Cell Line;Cells;Charge;Chordoma;Clinical;clinical application;Clinical Data;clinical efficacy;clinical implementation;clinical practice;Collaborations;Communities;Complication;Computational Technique;computer science;Computing Methodologies;Consensus;Custom;Data;Data Set;design;Development;Disease;Dose;dosimetry;Effectiveness;European;Evaluation;Event;flasks;Goals;Head;High-LET Radiation;Human;Human Cell Line;Hypoxia;Implementation readiness;improved;In Vitro;in vivo;innovation;ionization;Ions;irradiation;Japanese;Knowledge;Linear Energy Transfer;Machine Learning;Mammalian Cell;mathematical algorithm;mathematical sciences;Measurement;Measures;Medical;member;Methods;Modeling;Modernization;Molecular;Monte Carlo Method;Mus;nanoscale;Normal tissue morphology;novel;optimal treatments;Organ;particle;particle beam;particle therapy;Patients;Pattern;Pelvis;Performance;Photons;Physics;predictive modeling;Probability;Procedures;prospective;Prostate;prostate cancer cell;Protons;Radiation Oncology;radiation response;Radiation therapy;Radiobiology;Radiology Specialty;Relative Biological Effectiveness;Research;Research Design;response;Rodent;Roentgen Rays;Scanning;Science;side effect;simulation;Structure;Techniques;Technology;Testing;Therapy trial;Tissues;treatment planning;tumor;tumor xenograft;Validation

PROJECT_TITLE: Ionization Detail - Biologically based treatment planning for particle therapy beyond LET-RBE

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: LM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Networking and Information Technology R&D (NITRD);Social Determinants of Health

ORG_CITY: TUCSON

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Project Narrative This training program is designed to recruit 100 diverse undergraduate students over five years and prepare them to conduct research in health informatics. As a part of the training, students will address health problems in the Southwest, which will address health disparities in region and give students a meaningful experience.

PI_NAMEs: ERNST, KACEY C;SUBBIAN, VIGNESH  (contact)

PROJECT_TERMS: academic minor;Address;Area;Arizona;Awareness;biomedical informatics;Biomedical Research;career;Clinical;cohort;college;Communities;community college;Complex;Data Science;Data Set;design;disadvantaged student;Discipline;Ecology;Education;education research;Educational Curriculum;Engineering;Environment;ethnic minority population;experience;Faculty;faculty mentor;First Generation College Students;Fostering;gender minority group;graduate school preparation;Graduation Rates;Health;health data;health disparity;health equity;health equity promotion;Health Sciences;Hispanic-serving Institution;improved;Individual;Informatics;Information Sciences;innovation;Learning;marginalization;Mentors;Mentorship;Methods;Minor;Outcome;Participant;Persons;population health;Problem Solving;Process;programs;Public Health;Public Health Informatics;racial minority population;Recording of previous events;recruit;Research;Research Personnel;Research Project Grants;Research Training;retention rate;Science;skill acquisition;skills;socioeconomics;statistics;STEM field;Structure;student participation;Students;success;summer research;System;theories;Training;Training and Education;Training Programs;undergraduate student;Universities;Vision

PROJECT_TITLE: Place-based Culturally Responsive Health Informatics Research Education (PHIRE) Program


ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Understanding the whole spectrum of inherited and acquired genetic changes using established and emerging technologies will lead to effective diagnosis and treatment strategies for each patient's cancer. We undertake this work using a comprehensive suite of established bioinformatics tools to examine mutations and germline predisposition, tumor cell populations, evolution, and the tumor microenvironment; and integrate these dynamics into larger themes in cancer.

PI_NAMEs: DING, LI  (contact);GOVINDAN, RAMASWAMY

PROGRAM_OFFICER_NAME: YANG, LIMING

PROJECT_TERMS: Advanced Malignant Neoplasm;anti-cancer research;Area;ATAC-seq;Award;Back;Bioinformatics;bioinformatics tool;Biological;Cancer Center;cancer genomics;Cancer Patient;cancer type;Cell Lineage;cell type;Cells;Cellular Assay;Clinical;Code;cohort;Collection;combinatorial;Competence;Data;Data Analyses;data exchange;data integration;deep learning;Detection;Diagnosis;digital imaging;disorder subtype;DNA Sequence Alteration;Emerging Technologies;Epigenetic Process;Evolution;exome sequencing;Genes;Genetic Complementation Test;Genetic Transcription;genome sequencing;genomic data;Genomics;Germ Lines;Germ-Line Mutation;Goals;Heterogeneity;Histology;Human;improved;Individual;Inherited;insight;Letters;Link;Malignant Neoplasms;Medicine;Methods;Methylation;MicroRNAs;Molecular;Mutation;neoplastic cell;new technology;Pathogenicity;Pathway interactions;Pattern;Penetrance;Population;Predisposition;Production;programs;Quality Control;RNA Splicing;Sequence Analysis;single-cell RNA sequencing;Somatic Mutation;System;Technology;tool;Traction;transcriptome;transcriptome sequencing;transcriptomics;treatment strategy;Trees;tumor;tumor microenvironment;Twin Multiple Birth;Untranslated RNA;Variant;whole genome;Work;XCL1 gene

PROJECT_TITLE: Deep exploration of drivers, evolution, and microenvironment toward discovering principal themes in cancer


ORG_CITY: PROVIDENCE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative The ribosome is the macromolecular machine responsible for protein synthesis and deciphering its structure-function relationships is a fundamental biological problem. We will use a combination of genetics, molecular biology, and structural biology approaches to address basic questions of ribosome structural dynamics as they relate to function. The ribosome is also the target of more than half of all antibiotics, and a deeper understanding of the molecular mechanism of antibiotic resistance is an immediate outcome of this work.

PI_NAMEs: GREGORY, STEVEN ;JOGL, GERWALD  (contact);KHAYAT, REZA

PROGRAM_OFFICER_NAME: VATAKIS, DIMITRIOS NIKOLAOS

PROJECT_TERMS: Active Sites;Address;Affect;Amino Acid Substitution;anti-microbial drug;Antibiotic Resistance;Antibiotics;Binding;Binding Sites;Biochemistry;Biological;Capromycin;Codon Nucleotides;Collaborations;Collection;Complex;Cryoelectron Microscopy;Crystal Formation;Data;Dependence;Development;Drug Design;Elements;Equilibrium;Evolution;fighting;fitness;Future;Gene Expression;Genetic;Genetic study;Goals;Head;Health;Human;insight;Investigation;Laboratories;Methods;Molecular;Molecular Biology;Molecular Conformation;Molecular Machines;Motion;Movement;mutant;Mutation;Nature;novel;Outcome;Phenotype;Positioning Attribute;prevent;Protein Biosynthesis;Publications;Resistance;resistance mechanism;resistance mutation;Resolution;Ribosomal Proteins;Ribosomal RNA;Ribosomes;Role;Rotation;Signal Pathway;Signal Transduction;Site;Spectinomycin;Streptomycin;structural biology;Structure;Structure-Activity Relationship;Transfer RNA;Visualization;Work;X-Ray Crystallography

PROJECT_TITLE: Structural Robustness of Ribosome Functional Centers

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: PROJECT NARRATIVE This project integrates transcriptome and methylome of Barrett’s esophagus (BE), the key cancer precursor of esophageal adenocarcinoma (EAC), with existing genetic and environmental risk factor data in genome-wide association studies. The goal is to identify new genetic and epigenetic loci underlying susceptibility and develop prediction models for EAC. Findings are anticipated to aid in the identification of individuals who are at elevated risk of EAC and may benefit most from preventive interventions, ultimately helping to reduce the public health burden of this deadly cancer.

PI_NAMEs: BUAS, MATTHEW FRANK;KOOPERBERG, CHARLES L (contact)

PROGRAM_OFFICER_NAME: KALIA, SARAH SUJATA

PROJECT_TERMS: Address;Age;American;analytical method;Barrett Esophagus;bead chip;biobank;Biological Markers;Biometry;Biopsy;Cancer Center;cancer prevention;candidate validation;Clinical;cohort;college;Columnar Metaplasia;Comprehensive Cancer Center;Computing Methodologies;cost;Country;Data;deep neural network;Development;Diagnosis;Disease;Distal;Dysplasia;Environment;Environmental Exposure;Environmental Risk Factor;epidemiologic data;Epidemiology;epigenetic marker;Epigenetic Process;epigenome;epigenome-wide association studies;epigenomics;Esophageal Adenocarcinoma;Esophageal Tissue;Esophagus;Etiology;Funding;Gastroenterology;Gastroesophageal reflux disease;Gene Expression;Genetic;genetic association;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genome;genome wide association study;genome-wide;Genotype;Genotype-Tissue Expression Project;Goals;Guidelines;Heritability;high risk;high risk population;improved;Incidence;Individual;Indolent;innovation;Leadership;Length;Lesion;Life Style;Link;Malignant Neoplasms;Maps;Mediating;Mediation;Mediator;Meta-Analysis;Methodology;Methods;methylome;Modeling;Molecular;Molecular Abnormality;Molecular Probes;Multiomic Data;multiple omics;Non-Steroidal Anti-Inflammatory Agents;novel;Obesity;Pathway interactions;Patients;polygenic risk score;Population;predictive marker;predictive modeling;Predisposition;Prevalence;prevent;Prevention;preventive intervention;progression marker;Public Health;Publishing;rare cancer;Reflux;Research;Resources;Risk;Risk Factors;risk prediction;risk prediction model;Risk Reduction;risk stratification;risk variant;Role;Sample Size;screening;sex;Smoking;Specimen;Survival Rate;Susceptibility Gene;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomic profiling;tumor progression

PROJECT_TITLE: Genetics, Epigenetics, and Risk Prediction for Esophageal Adenocarcinoma

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biotechnology;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related;Women's Health Research

ORG_CITY: WINSTON-SALEM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: RELEVANCE The goal of the research proposed in the current application is to understand how the immune system is regulated to respond to polysaccharide vaccines important for protection against Streptococcus pneumoniae. We are specifically focusing on the aged population and on identifying key differences between males and females. The knowledge gained from these studies may lead to improved sex- and age-appropriate vaccines that provide enhanced protection against pneumococcal infections currently threatening global public health.

PI_NAMEs: HAAS, KAREN M (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Adult;Advisory Committees;Age;age difference;age effect;age related;age related changes;aged;Aging;aging population;aging related;Antibiotic Resistance;Antibodies;Antibody Formation;Antibody Response;Antibody titer measurement;Antigens;B-Lymphocytes;Bacteremia;biological sex;C57BL/6 Mouse;capsule;Cell Wall;Cells;Cessation of life;Decision Making;design;Development;Disease;Elderly;Estrogens;Female;Future;Gender;gender affirmation;gender affirming therapy;Global Change;Goals;Gonadal Steroid Hormones;Hormones;Human;Humoral Immunities;Immune system;Immunity;Immunization;Immunoglobulin G;Immunoglobulin M;improved;Infection;Investigation;Knowledge;life span;male;middle age;Modeling;mouse model;mucosal vaccine;Mucous Membrane;Mus;natural antibodies;Patients;Phenotype;Phosphorylcholine;Physiological;Play;Pneumococcal Infections;Pneumococcal Pneumonia;Pneumococcal vaccine;Pneumonia;Pneumovax;Polysaccharides;Polyvalent pneumococcal vaccine;Population;Populations at Risk;prevent;Public Health;rational design;Reaction;Recommendation;Regulation;Research;Resistant Streptococcus pneumoniae;response;Role;Serotyping;sex;Sex Bias;Sex Differences;Streptococcus pneumoniae;Testing;Transcription Alteration;Vaccination;vaccine response;vaccine strategy;Vaccines

PROJECT_TITLE: THE IMPACT OF ADVANCED AGE AND SEX ON HUMORAL IMMUNITY TO STREPTOCOCCUS PNEUMONIAE


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prevention;Skin Cancer

ORG_DEPT: DERMATOLOGY

PHR: Project Narrative Compared to other cancer subtypes with similar incidences, mortalities, and economic burdens, little is known about the genetic landscape and evolution of cutaneous squamous cell carcinoma. For this grant, we will address these gaps in knowledge. Completion of these studies will overcome major obstacles that are currently hindering the development of new therapies and prevention strategies.

PI_NAMEs: SHAIN, ALAN HUNTER (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Actinic keratosis;Address;Attention;Automobile Driving;Benign;Biological Markers;biomarker development;Caliber;cancer subtypes;cancer type;Cataloging;Catalogs;Cells;Cellularity;Cessation of life;Communities;Consensus;Data;deep sequencing;Dermatology;Development;Disease;Disease Progression;DNA Sequence Alteration;driver mutation;drug development;Economic Burden;Epidemic;Etiology;Event;Evolution;exome;exome sequencing;fighting;gene discovery;Genes;Genetic;genetic evolution;genome sequencing;Genomics;Genotype;Goals;Grant;high risk;Human;Immunotherapy;improved;Incidence;Individual;Infiltration;innovation;insight;Institution;Intervention;keratinocyte;Knowledge;Large-Scale Sequencing;Lesion;Malignant neoplasm of cervix uteri;Malignant neoplasm of liver;Malignant Neoplasms;malignant state;malignant stomach neoplasm;Measures;Melanoma;mortality;Mutation;Neoplasms;neoplastic;Neoplastic Keratinocyte;novel therapeutic intervention;novel therapeutics;Oncogenes;Patients;Persons;Phase;premalignant;Prevention;Prevention strategy;Public Health;Renal Carcinoma;Research;Resolution;response;Sensitivity and Specificity;Skin;Skin Cancer;skin squamous cell carcinoma;Somatic Mutation;Source;Stromal Cells;Sun Exposure;Surgeon;The Cancer Genome Atlas;Therapeutic;Time;tumor;Tumor Subtype;United States

PROJECT_TITLE: The genomic landscape and evolution of cutaneous squamous cell carcinoma


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Genetics;Heart Disease;Hypertension;Pediatric;Pediatric Cardiomyopathy;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PHR: Hypertrophic Cardiomyopathy is a genetically inherited disorder that causes sudden death in young people, but not every patient with Hypertrophic Cardiomyopathy mutations experiences symptoms of the disease. We propose that differences in mechanical stress caused by blood pressure trigger for symptoms in Hypertrophic Cardiomyopathy patients, and that understanding molecular mechanisms linking blood pressure and disease progression will help us develop new treatments. We will use human stem cells that express Hypertrophic Cardiomyopathy mutations to create a heart tissue model in a dish and use these tissues to identify molecular mechanisms that cause the disease triggering mutations.

PI_NAMEs: HUEBSCH, NATHANIEL  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3D Print;Action Potentials;Animal Model;Animals;Aorta;Biocompatible Materials;Biological Models;Blood Pressure;blood pressure reduction;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cells;Clinical;Data;Development;Disease;Disease Progression;Dose;elastomeric;Elastomers;engineered stem cells;Engineering;Epigenetic Process;experience;Failure;Family;Future;Gene Expression;Genes;Genetic;Genetic study;Genotype;HDAC1 gene;Heart;Heart Diseases;Heart Hypertrophy;Hematological Disease;Hereditary Disease;Heterogeneity;Histone Deacetylase;human induced pluripotent stem cells;human stem cells;Hydrogels;Hypertension;hypertension control;hypertensive;Hypertrophic Cardiomyopathy;Hypertrophy;In Situ;In Vitro;in vivo;Individual;Induced Mutation;induced pluripotent stem cell;induced pluripotent stem cell derived cardiomyocytes;Inherited;Link;loss of function mutation;magnetic field;Magnetism;mechanical load;Mechanical Stress;Mechanics;Medicine;Mitogen-Activated Protein Kinases;Molds;Molecular;Morphology;mouse model;mutant;Mutation;Myocardium;myosin-binding protein C;non-genetic;non-invasive monitor;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathogenesis;Pathologic;Pathology;Patients;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phenotype;Physiological;programs;prophylactic;Protein C Deficiency;Proteins;Research Design;Resistance;response;Role;role model;Sarcomeres;scaffold;Signal Transduction;Structure;Sudden Death;Symptoms;System;Technology;Testing;Therapeutic;Time;Tissue Model;Tissues

PROJECT_TITLE: Biomaterial Platforms to Model the Role of Mechanical Overload in MYBPC3-Linked Hypertrophic Cardiomyopathy

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Correct gene expression is fundamental to all aspects of healthy biology. This proposal seeks a better understanding of the functions of the RNA modification pseudouridine, which has significant but poorly understood effects on human gene expression. This research will have the potential to reveal new therapeutic targets to treat diseases caused by mutations in the enzymes that modify RNAs with pseudouridine.

PI_NAMEs: GILBERT, WENDY VICTORIA (contact)

PROJECT_TERMS: Affect;Base Pairing;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Process;Biology;Birth;cell type;Cells;Cellular Stress;Cessation of life;chemical property;Chemicals;Data;defined contribution;Deposition;Digestive System Disorders;Disease;Dyskeratosis Congenita;Enzymes;Etiology;Eukaryotic Cell;gene correction;Gene Expression;Gene Expression Regulation;genetic manipulation;Genetic Transcription;Goals;Health;HepG2;Human;human disease;In Vitro;Intellectual functioning disability;Isomerism;Knowledge;Link;Malignant Neoplasms;Measurement;Mediating;Messenger RNA;Metabolism;Methods;MicroRNAs;Mitochondrial Myopathies;Modification;Molecular;Molecular Conformation;mRNA Export;mRNA Precursor;Mutation;new therapeutic target;novel;Nucleosides;Physiological;Proteins;Pseudouridine;Reader;Regulation;Research;Resistance;RNA;RNA-Binding Proteins;RNA-Protein Interaction;Role;Site;stoichiometry;Testing;transcriptome;Translations;Untranslated Regions;Uridine;Vertebral column;Virus Diseases;Work

PROJECT_TITLE: Functions of mRNA Pseudouridylation

STUDY_SECTION: MG

STUDY_SECTION_NAME: Molecular Genetics Study Section[MG]


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative This study aims to develop an integrative modeling framework of complex genetic diseases to utilize high- resolution cell architecture from single-cell sequencing data, in conjunction with large-scale bulk sequencing data. We will systematically identify context-matched pairs of publicly available bulk and single-cell studies, characterize multi-scale cell architectures by a novel unsupervised cell clustering approach, and construct network models integrating across molecular modalities and cellular resolutions. The network models will be validated by genetic or chemical perturbation data in model systems from public databases, and shed lights on underpinning mechanisms and potential therapeutic strategies.

PI_NAMEs: SONG, WON-MIN  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Algorithms;Architecture;Biological Models;Biology;Cells;Chemicals;Clinic;Clinical;cohort;Complex;cost;Data;Data Set;Disease;disease model;Etiology;gene interaction;Genes;Genetic;Genetic Diseases;Genetic Models;genetic signature;genomic signature;Genomics;human disease;interest;Measures;Modality;Modeling;Molecular;molecular modeling;multimodality;Nature;network models;novel;novel therapeutic intervention;parallelization;Pathway Analysis;Phylogeny;Population;public database;Public Domains;Resolution;Sampling;Signal Pathway;Signal Transduction;single cell sequencing;System;Technology;Testing;Therapeutic;Tissues

PROJECT_TITLE: Integrative network modeling of bulk and single-cell sequencing data to characterize multi-scale cell architecture

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Conventional dendritic cells (CDC) play a central role in immunity including protective responses against pathogens and cancer, autoimmune diseases, outcome of organ transplantation, and response to vaccines. To support their many roles, CDCs have specialized subsets in tissue but mechanisms controlling their tissue distribution are poorly understood. Our work will uncover a novel pathway by which metabolic changes in tissue regulate local distribution of CDC subsets.

PI_NAMEs: HALDAR, MALAY  (contact)

PROGRAM_OFFICER_NAME: ROY, CINDY

PROJECT_TERMS: adaptive immune response;Affect;alpha ketoglutarate;amino acid metabolism;Amino Acids;antagonist;Antigen Presentation;Antigen-Presenting Cells;Antioxidants;Autoimmune Diseases;bisulfite sequencing;Blood;Bone Marrow;CDC2 gene;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell Survival;Cells;ChIP-seq;Chromatin;cofactor;Consumption;coping;Cross Presentation;Data;demethylation;Dendritic Cells;Detection;Development;DNA;DNA Methylation;Drug or chemical Tissue Distribution;Enzymes;Epigenetic Process;epigenetic regulation;Flow Cytometry;Frequencies;Funding Mechanisms;Gatekeeping;Gene Expression Regulation;Genes;Genetic;GLS2 gene;Glutamates;Glutaminase;Glutamine;Glutathione;Growth;Guidelines;hematopoietic differentiation;Hematopoietic stem cells;histone methylation;Human;immune modulating agents;Immune response;Immune system;Immunity;immunoregulation;Immunotherapeutic agent;in vitro Model;in vivo;Infiltration;Inflammation;Innate Immune Response;Isoenzymes;Link;lymphoid organ;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;Metabolic;Metabolism;Molecular;Myeloid Progenitor Cells;NADP;Natural Immunity;novel;Organ Transplantation;Outcome;Oxidative Stress;pathogen;Pathologic;Pathologic Processes;Pathway interactions;Pattern recognition receptor;Peripheral;pharmacologic;Play;Process;Production;progenitor;Promoter Regions;Property;Reactive Oxygen Species;Regulation;Research;response;Role;single-cell RNA sequencing;small molecule inhibitor;Stress;T-Lymphocyte;Testing;Tissue Differentiation;Tissues;transcription factor;tumor-immune system interactions;uptake;Vaccines;Virus;Work

PROJECT_TITLE: Role of glutamine metabolism in Dendritic Cell Development

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Nutrition;Pediatric

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: COLUMBIA UNIVERSITY TEACHERS COLLEGE

PHR: PROJECT NARRATIVE Creating Resources Uplifting Nutrition, Culture, and Health at Lunch (CRUNCH Lunch) is an innovative program to increase’s elementary school students Science, Technology, Engineering, and Math (STEM) interest and food literacy by connecting STEM with the everyday act of eating school lunch. CRUNCH Lunch is being developed and evaluated using a diverse, urban elementary school aged population, with over 15,000 students and over 700 teachers. Through professional development, teachers examine their beliefs surrounding school lunch, develop an understanding of the benefits of school, learn evidenced-based methods to link STEM topics to school lunch, and receive robust web-based supports, which is systematically connected STEM to school lunch for the first time.

PI_NAMEs: KOCH, PAM ANN (contact)

PROGRAM_OFFICER_NAME: FAUPEL-BADGER, JESSICA

PROJECT_TERMS: Attention;Attitude;Belief;Biology;Carrots - dietary;Chemistry;Child;Chronic Disease;Color;Communicable Diseases;Communities;comparison control;Consumption;cooking;COVID-19 pandemic;Development;Diet;Diet Habits;Eating;Education;Educational process of instructing;Educational workshop;elementary school;empowerment;Enrollment;Environment;Equity;Evaluation;evidence base;experience;Faculty Workshop;fifth grade;Food;Food production;food quality;Future Generations;girls;Goals;Health;health literacy;Heart;improved;innovation;interest;Learning;Life Experience;Link;literacy;mathematical learning;Mathematics;Measures;Metabolic;Methods;Mind;New York City;nutrition;nutrition education;Nutritional;Nutritional Science;Online Systems;Outcome;Persons;poverty reduction;prevent;Primary School Faculty;programs;Research;Resource Development;Resources;School-Age Population;Schools;Science;science education;Science, Technology, Engineering and Mathematics;Science, Technology, Engineering and Mathematics Education;Scientist;Smell Perception;sound;STEM career;Students;teacher;Texture;Time;Transportation;United States;Videoconferencing;Vision;Work

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-H(55)R]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Physical Injury - Accidents and Adverse Effects;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: DALLAS

ORG_DEPT: NEUROLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia. The goal of this study is to determine whether acute (< 1 week) cerebrovascular injury and its recovery within the first year postinjury measured by cerebral autoregulation and brain perfusion are associated with cognitive outcome at 12 months after msTBI. The results from this study will improve our understanding of cerebrovascular contributions to cognitive decline related to TBI and provide critical data to inform the development of strategies based on vascular mechanisms to improve cognition after msTBI.

PI_NAMEs: DING, KAN  (contact);ZHANG, RONG ;ZHU, DAVID C

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Accounting;Acute;Address;Adult;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;Attention;Axon;axon injury;Bilateral;Blood Flow Velocity;Blood Pressure;Blood Vessels;Brain;Brain imaging;Brain Injuries;Brain region;brain tissue;brain volume;Cephalic;cerebral autoregulation;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrovascular Physiology;Chronic;Clinical;clinical care;Cognition;Cognitive;cognitive performance;cognitive recovery;crosslink;Data;Dementia;Development;diagnostic strategy;disability;Disease;economic cost;epidemiology study;Episodic memory;Etiology;experience;Fingers;functional outcomes;Goals;Health;hemodynamics;hypoperfusion;imaging approach;imaging biomarker;Impaired cognition;Impairment;improved;Individual;individual variation;Injury;injury recovery;Internal carotid artery structure;Knowledge;late life;Liquid substance;Longitudinal Studies;Magnetic Resonance Imaging;Measures;Mediating;Memory impairment;multimodality;Near-Infrared Spectroscopy;Nerve Degeneration;Neurobehavioral Manifestations;Neurocognitive;neuroimaging;noninvasive diagnosis;Nonpharmacologic Therapy;Orthopedics;Outcome;Perfusion;pharmacologic;Photoplethysmography;Population;primary outcome;processing speed;Quality of life;Recovery;Recovery of Function;Research;Research Priority;Severities;sex;Structure;Sum;Survivors;symposium;targeted treatment;Time;tissue oxygenation;Trauma;Traumatic Brain Injury;Traumatic Brain Injury recovery;Ultrasonography;United States National Institutes of Health;vascular contributions;vertebral artery;white matter

PROJECT_TITLE: Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury (CAPCOG-TBI)

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Radiation Oncology;Women's Health Research

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The goal of this proposal is to elucidate key mechanisms that regulate hypoxia in tumors. The aims that we have outlined should enable us to generate tumors that are more sensitive to radiation treatment and represent a novel therapeutic strategy for treatment of triple-negative breast cancer.

PI_NAMEs: ROSNER, MARSHA R (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: aggressive breast cancer;angiogenesis;Angiogenic Factor;Antioxidants;BACH1 gene;biological adaptation to stress;Blood flow;Breast Cancer Cell;breast cancer metastasis;Breast Cancer Patient;cancer cell;Cancer Etiology;Cancer Patient;cancer subtypes;Catabolism;Cell Hypoxia;chemotherapy;Clinical;Clinical Trials;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;cytotoxic;Cytotoxic Chemotherapy;Data;Disease;Drug Delivery Systems;Endothelial Cells;Epigenetic Process;ERBB2 gene;FDA approved;Gene Expression;gene repression;Genes;Genetic Transcription;Goals;Heme;Hemin;Hormone Receptor;Hypoxia;Hypoxia Inducible Factor;Immunotherapy;improved;inhibitor;Localized Malignant Neoplasm;Malignant Breast Neoplasm;Mediating;Metabolic;migration;mortality;mouse model;multicatalytic endopeptidase complex;Mus;mutant;neoplastic cell;novel;novel therapeutic intervention;overexpression;oxidation;Oxygen;Oxygen Therapy Care;Patients;Pharmaceutical Preparations;Phenotype;Play;Production;prognostic;programs;public health relevance;Publishing;Radiation;radiation resistance;Radiation therapy;Refractory;Regulation;Resistance;response;Role;Scheme;Signal Transduction;small hairpin RNA;Specificity;standard of care;Stress;Survival Rate;Testing;Therapeutic;transcription factor;Transcriptional Regulation;Treatment Efficacy;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor hypoxia;tumor microenvironment;Tumor Oxygenation;Ubiquitin;Women's mortality;Work;Xenograft procedure

PROJECT_TITLE: Regulation of Tumor Oxygenation by BACH1 in Breast Cancer

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Diabetes;Eye Disease and Disorders of Vision;Gene Therapy;Genetics;Immunization;Macular Degeneration;Nanotechnology;Neurodegenerative;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE The current antibody drug therapies for proliferative diabetic retinopathy and diabetic macular edema require repeated, monthly intraocular injections to maintain the therapeutic dose, risking both injection site inflammation and drug-induced retinal injury. This project employs a targeted nanoparticle therapy containing small interfering RNAs (siRNAs) that are directed toward the pathogenic protein synthesis machinery. Our preliminary data demonstrates these nanoparticles, with further development, could greatly extend efficacy, thereby reducing the frequency of intraocular injections required to maintain disease remission and avoid the side effects of the current standard of care.

PI_NAMEs: FREEMAN, WILLIAM R. (contact);SAILOR, MICHAEL J

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Acids;Adverse effects;Affect;Age related macular degeneration;Amines;Animal Diseases;Animal Model;animal tissue;Antibodies;Antibody Therapy;Bacterial Infections;Benchmarking;bevacizumab;Biological Assay;biological systems;biomaterial compatibility;Biotinylation;Blindness;Blood Vessels;Calcium;Cell Culture Techniques;Cell Line;Cell surface;Cells;cellular targeting;Characteristics;Charge;Chemistry;Clinical;clinical development;Cryoelectron Microscopy;cytotoxicity;Data;Daunorubicin;delivery vehicle;design;Development;Dexamethasone;diabetic;Diabetic Retinopathy;Diffusion;Disease;Disease remission;Dose;Drug Delivery Systems;Drug Kinetics;Effectiveness;Emerging Technologies;Encapsulated;Endosomes;Enzyme-Linked Immunosorbent Assay;Extravasation;Eye diseases;Eye Hemorrhage;Flow Cytometry;Fluorescein;Fluorescein Angiography;Formulation;Frequencies;geographic atrophy;Glucose;Goals;Half-Life;Homeostasis;Image;Immunohistochemistry;improved;In Vitro;in vivo;Industrialization;Infection;Inflammation;Injections;Injury;Integrins;interest;intravitreal injection;Ischemia;Kinetics;knock-down;Label;Lipids;macular edema;Measurable;Measures;Membrane Lipids;Methodology;Methods;Modeling;Modification;Monitor;nanoparticle;nanosized;Nature;neovascular;neovascularization;Neuropilin-1;novel;novel therapeutics;Oryctolagus cuniculus;Outcome;overexpression;particle;Pathogenicity;Penetration;Peptides;Periodicity;Persons;Pharmaceutical Preparations;Pharmacotherapy;Physical condensation;physical property;Porosity;Prevalence;proliferative diabetic retinopathy;Protein Biosynthesis;Proteins;randomized, clinical trials;Research;Retina;Retinal Neovascularization;retinal toxicity;Risk;RNA;RNA delivery;RNA Interference;RNA Interference Therapy;RNA Sequences;Safety;side effect;Silanes;Silicates;Silicon;siRNA delivery;Sirolimus;Site;Small Interfering RNA;Solvents;Specificity;standard of care;Structure;Subgroup;Surface;System;Technology;Testing;Therapeutic;Therapeutic Agents;Therapeutic antibodies;therapeutic nanoparticles;therapeutic RNA;therapeutic siRNA;therapy duration;Time;Tissues;Treatment Efficacy;tumor;United States Food and Drug Administration;uptake;Vascular Endothelial Growth Factors;Western Blotting

PROJECT_TITLE: Intracellular RNA Nanoparticle Therapeutics to Treat Retinal Neovascularization


NIH_SPENDING_CATS: Clinical Research;Hematology

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inhibition of coagulation factor XII (FXII) could be a transformative new approach to antithrombotic treatment that decouples therapeutic efficacy from the risk of bleeding complications. This proposal will explore the molecular mechanisms of FXII recruitment, activation, and propagation at the platelet surface. Elucidation of these processes is essential to the development of novel anti-thrombotic therapeutics based on FXII blockade.

PI_NAMEs: BENDAPUDI, PAVAN  (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Affinity;Anticoagulation;Binding;Binding Sites;Biological Assay;Blood Coagulation Disorders;Blood Platelets;Cell Line;Clinical;Co-Immunoprecipitations;Coagulation Process;Competitive Binding;Complex;Cryoelectron Microscopy;Data;Deuterium;Development;Disease susceptibility;Drug Targeting;Electron Microscopy;Enzyme Precursors;Event;Exhibits;experimental study;factor A;Factor XII;Factor XII Deficiency;Factor XIIa;Fibrinolytic Agents;Flow Cytometry;follow-up;Follow-Up Studies;Generations;Hemorrhage;Hemostatic function;Human;Hydrogen;In Vitro;in vivo;inhibitor;insight;Integrin Binding;Integrins;interest;Interferometry;Knockout Mice;Kringles;Ligands;Maps;Mass Spectrum Analysis;Mediating;Membrane Proteins;microscopic imaging;Molecular;Molecular Conformation;mouse model;Negative Staining;novel;novel strategies;novel therapeutics;particle;Pathway interactions;Patients;Phase;Physiological;Plasma;Play;Pre-Clinical Model;prevent;Process;Property;Proteomics;Reagent;receptor;Recombinant Proteins;Recombinants;reconstitution;recruit;Reproducibility;Research Personnel;RGD (sequence);Risk;Role;Signal Transduction;Site;Solid;stem;Surface;targeted agent;Therapeutic;therapeutic target;Thrombosis;thrombotic;Thrombus;Treatment Efficacy;vascular injury;Work

PROJECT_TITLE: Coagulation Factor XII Recruitment and Activation During Thrombus Formation

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Asthma;Climate-Related Exposures and Conditions;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Social Determinants of Health

ORG_DEPT: SOCIAL SCIENCES

PHR: PROJECT NARRATIVE  This project will investigate the effect of PM2.5, a ubiquitous air pollutant, on the biosynthesis and degradation of specialized pro-resolving mediators (SPMs) during the dynamic process of inflammation initiation to resolution in the respiratory tract. Potential differences by asthma and sex will be examined. This project will be carried out using a translational approach integrating a cell culture mechanistic investigation and a human observational study of SPMs and inflammation resolution in adults exposed to urban traffic PM2.5.

PI_NAMEs: ZHANG, JUNFENG  (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Adult;Affect;Age;Air;Air Pollutants;Air Pollution;airway epithelium;airway inflammation;Anabolism;Animals;Anti-Inflammatory Agents;Applied Research;Asthma;asthma exacerbation;asthmatic;asthmatic airway;Biological Markers;CD59 Antigen;Cell Culture Techniques;Cells;Chemicals;chronic inflammatory disease;Clinical;clinically relevant;Coculture Techniques;Collecting Cell;Data;Data Set;Disease;DNA Methylation;Dose;Environmental Exposure;epigenetic profiling;epigenetic regulation;Epithelial Cells;experimental study;Exposure to;fine particles;fundamental research;Genes;Genetic Transcription;Health;Homeostasis;Hour;Human;Immune response;Impairment;In Vitro;in vivo;Individual;Inflammation;Inflammation Process;Inflammatory;Inflammatory Response;Inhalation;interest;Intervention;Investigation;Kinetics;Knowledge;Life;Link;Lipoxins;Liquid substance;Literature;London;Lung;Measurement;Measures;Mediating;Mediation;Mediator;men;Molecular;Nasal Epithelium;National Institute of Environmental Health Sciences;neutrophil;Nose;novel;Observational Study;Outcome;Oxidative Stress;Participant;Pathway interactions;Persons;Pharmaceutical Preparations;Pollution;Predisposition;prevent;Protocols documentation;pulmonary function;Pulmonary Inflammation;Resolution;Respiratory System;response;Role;Sample Size;sex;Sex Differences;Signal Transduction;Site;Source;Sputum;Stimulus;Symptoms;Testing;Time;Tissues;transcriptome sequencing;translational approach;translational study;urinary;Woman;women versus men

PROJECT_TITLE: Molecular Mechanisms for Resolving Air Pollution Induced Pulmonary Inflammation: Potential Differences by Asthma and Sex (RAPIDAS)

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biotechnology;Clinical Research;Immunization;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

PHR: PROJECT NARRATIVE Klebsiella pneumoniae is a bacterium that frequently causes pneumonia, urinary tract infection, and bloodstream infection and is increasingly causing severe illness and death in hospitalized patients. A vaccine to prevent infection with antibiotic-resistant Klebsiella pneumoniae could potentially save many lives, but little is known about the how the immune system responds to this organism. This proposal focuses on the sugars attached to the surface of Klebsiella pneumoniae and how these perform as components of vaccines.

PI_NAMEs: ROSEN, DAVID A. (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: adaptive immune response;Animals;Antibiotic Resistance;Antibodies;Antibody Response;Antigens;Bacteremia;Bacteria;bactericidal immunity;bactericide;Bacteriology;Binding;Biological Assay;capsule;carbapenem resistant Enterobacterales;Carrier Proteins;Cells;Cessation of life;chemical conjugate;Communities;Complement;Conjugate Vaccines;cross immunity;Data;Dependence;Development;DNA Sequence Alteration;Dose;Effectiveness;efficacy evaluation;Encapsulated;Engineering;Enrollment;Enzyme-Linked Immunosorbent Assay;Escherichia coli;Europe;Exhibits;experimental study;Goals;healthcare-associated infections;Hospitalization;Human;human pathogen;Humoral Immunities;Immune response;Immune Sera;Immune system;Immunity;Immunization;Immunize;Immunoelectron Microscopy;Immunofluorescence Microscopy;Immunoglobulin G;in vivo;Infection;Infection prevention;inhibiting antibody;inhibitor;Interferometry;Klebsiella;Klebsiella pneumoniae;Licensing;Link;Liver Abscess;longitudinal human study;manufacturing process;Measures;Meningitis;Modeling;Monitor;mouse model;Multi-Drug Resistance;Mus;mutant;Names;novel;O Antigens;Organism;Ozone;Parents;participant enrollment;pathogen;Pathogenesis;Patients;Pneumonia;Polysaccharides;prevent;Pulmonary Challenge;Recombinants;relative effectiveness;Research Personnel;resistant Klebsiella pneumoniae;response;Sepsis;Serum;Specificity;Structure;sugar;Surface;Techniques;Testing;Time;Transmission Electron Microscopy;transmission process;Urinary tract infection;Vaccinated;Vaccination;vaccine access;vaccine development;vaccine failure;vaccine formulation;Vaccines;Virulent;Work

PROJECT_TITLE: Protective immunity elicited by distinct polysaccharide antigens of classical and hypervirulent Klebsiella

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Neurofluid circulation has gained much attention in light of its likely relevance to neurodegenerative and cerebrovascular disorders, including but not limited to Alzheimer’s Disease Related Dementias (ADRDs). Fundamental to the effective circulation of neurofluids is cerebrospinal fluid (CSF) production activity, which occurs within the choroid plexus (ChP) complexes located within each of the four brain ventricles; despite this, we lack rigorous and quantitative methods for quantifying ChP activity, thereby limiting abilities to evaluate CSF circulation in different neurodegenerative disorders, as well as in response to emerging therapies. The overall goal of this work is to refine and clinically evaluate neuroimaging methods to enable quantitation of ChP anatomy and function non-invasively in vivo; if successful, this will allow for ChP function to be interrogated reliably in the growing number of applications where neurofluid and CSF circulatory dysfunction are implicated.

PI_NAMEs: DONAHUE, MANUS J (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: Address;Adult;Age;Algorithms;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease related dementia;Amyloid;Anatomy;Arachnoid mater;arterial spin labeling;Attention;Biochemical;biological sex;Blood;Blood Vessels;Calibration;Cerebral aqueduct;Cerebral Ventricles;Cerebrospinal Fluid;cerebrospinal fluid clearance;cerebrospinal fluid flow;Cerebrovascular Circulation;Cerebrovascular Disorders;circadian;Circadian Rhythms;Circulation;Clinical;Communication;Complement;Complex;Data;deep learning;deep learning algorithm;Dementia;Deposition;Disease;Diurnal Rhythm;Female;Foundations;Functional disorder;Future;glymphatic system;Goals;Health;Heart Atrium;hemodynamics;Human;Hypertrophy;imaging modality;Impairment;improved;in vivo;kinetic model;Knowledge;lateral ventricle;Light;Link;Liquid substance;Literature;lymphatic vessel;Magnetic Resonance Imaging;male;Measurement;Measures;Methodology;Methods;Modeling;Molecular;molecular marker;Nerve Degeneration;Neurodegenerative Disorders;neuroimaging;novel;older adult;Participant;Partition Coefficient;Pathway interactions;Peptides;Perfusion;perfusion imaging;Physiology;Positron-Emission Tomography;Production;protein biomarkers;quantitative imaging;Relaxation;Reporting;Reproducibility;Resolution;Resources;response;Role;Route;Severities;Signal Transduction;Site;Sleep;Stress;Structure of choroid plexus;Suggestion;symptomatology;Testing;Time;Tissues;Variant;Vascular Diseases;Venous system;volunteer;Wakefulness;Water;Work;β-amyloid burden

PROJECT_TITLE: Quantitative imaging of choroid plexus function and neurofluid circulation in Alzheimer's Disease Related Dementia

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Biomedical Imaging;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Radiation Oncology

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Brain metastases (BM) are the most commonly diagnosed type of central nervous system tumor. Arterial spin labeling (ASL) is ideal for frequent non-invasive longitudinal monitoring of tumor vascularity. This project proposes a prospective and comprehensive evaluation of state-of-art ASL perfusion mapping methods on BM patients for both early predicting treatment outcome and distinguishing true recurrence from radiation effects during the follow-up monitoring, which can be readily utilized as a practical and cost-effective imaging biomarker for multi-center and multi-vendor clinical studies of BM.

PI_NAMEs: QIN, QIN  (contact)

PROGRAM_OFFICER_NAME: KIM, BOKLYE

PROJECT_TERMS: 3-Dimensional;Acceleration;Adopted;arterial spin labeling;Base Sequence;Blood Vessels;blood-brain barrier disruption;Brain;Brain Neoplasms;Central Nervous System Neoplasms;cerebral blood volume;Cerebrovascular Circulation;Clinical;clinical application;clinical examination;Clinical Research;Clinical Trials;contrast enhanced;cost effective;Data;detection sensitivity;Development;Diagnosis;diagnostic accuracy;Early treatment;Enhancing Lesion;Ensure;Evaluation;Extravasation;follow-up;Glioma;healthy volunteer;Image;imaging biomarker;Immunotherapy;improved;individualized medicine;Intracranial Neoplasms;Label;Magnetic Resonance Imaging;Maps;Measurement;Measures;Metastatic malignant neoplasm to brain;Metastatic/Recurrent;Methodology;Methods;Monitor;Morphologic artifacts;Motion;Multi-site clinical study;Neoplasm Metastasis;Nervous System Physiology;older patient;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Perfusion;perfusion imaging;Prediction of Response to Therapy;Predisposition;Primary Brain Neoplasms;Primary Neoplasm;prospective;Protocols documentation;Radiation;radiation effect;Radiation therapy;Radiosurgery;reconstruction;Recurrence;Reproducibility;response;Signal Transduction;Site;Specificity;Standardization;targeted treatment;Techniques;temporal measurement;Time;Treatment outcome;treatment response;tumor;Tumor Markers;tumor progression;Vendor

PROJECT_TITLE: Development and Evaluation of Advanced Non-Contrast Perfusion MRI for Monitoring Treatment Response in Brain Metastases

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Neurodegenerative;Neurosciences;Opioids;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Human;Substance Misuse

PHR: Narrative HIV infection of the brain leads to neuropathogenesis despite antiretroviral therapy (ART)-mediated viral suppression via complex mechanisms that remain largely unknown. We propose to develop a new human model to study the cellular and molecular mechanisms underlying HIV neuropathogenesis, and the potential interactive, additive, or synergistic effects of ART and opioid exposure, using a microglia-infused brain cortical organoid system. This model will allow HIV infection and its related pathophysiological events and help to disentangle the contribution and interplay of relevant immune cells to neuronal damage.

PI_NAMEs: MUOTRI, ALYSSON R. (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Adherent Culture;advanced disease;Animal Model;antiretroviral therapy;Astrocytes;Biopsy;Blood;Brain;Brain Diseases;brain dysfunction;brain tissue;Buprenorphine;buprenorphine treatment;Cardiac Myocytes;Cell Line;cell type;Cells;Central Nervous System;Complex;Deacetylation;Disease;Enzymes;Epidemic;Event;experimental study;Exposure to;extracellular;Functional disorder;Gene Expression;Gene Expression Profile;Generations;Genomics;Goals;Histone Acetylation;Histone Deacetylation;HIV;HIV Infections;HIV-1;Human;human induced pluripotent stem cells;human model;human pluripotent stem cell;Immune;Immune response;Immunologic Markers;In Vitro;Individual;induced pluripotent stem cell;Infection;innovation;innovative technologies;Integration Host Factors;Learning;Link;Mediating;Memory;methadone treatment;Methods;Microglia;Modeling;Modification;Molecular;Morphine;morphometry;neural network;neuroAIDS;neuroinflammation;Neurologic;Neuronal Dysfunction;Neuronal Plasticity;Neurons;Neuropathogenesis;neuropathology;Opioid;opioid exposure;Opioid Rotation;opioid use;Organoids;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Pharmaceutical Preparations;Phenotype;Predisposition;Protocols documentation;Risk;self assembly;single-cell RNA sequencing;Site;Stem Cell Development;success;synaptogenesis;System;Technology;three dimensional structure;Time;Tissue-Specific Gene Expression;Tissues;transcriptome;Viral;Viremia;Virus Replication

PROJECT_TITLE: A new brain organoid model for NeuroHIV and the impact of opioids


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Disability Research;Health Services;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: Columbus

ORG_DEPT: PHYSICAL MEDICINE & REHAB

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: The current proposal seeks to compare the effectiveness of specific inpatient rehabilitation approaches to optimize functional outcomes and community participation for persons with traumatic brain injury. Revealing the most effective approaches associated with the best outcomes will be investigated through a prospective observational dataset based on clinician-driven design of standardized electronic medical records documentation and analyzed with advanced statistical methods. The results will have the potential to advance standards of practice in rehabilitation and to arm clinicians and healthcare administrators with evidence-based results to advocate for the use of the most effective practices in TBI rehabilitation.

PI_NAMEs: BEAULIEU, CYNTHIA L.;BOGNER, JENNIFER A (contact);HADE, ERINN M.

PROGRAM_OFFICER_NAME: HARTMAN, ADAM L

PROJECT_TERMS: Address;Administrator;Advocate;arm;behavioral impairment;Benchmarking;Biological Models;Chronic;Clinical;clinical practice;clinically significant;cohort;Collaborations;Communities;Community Participation;comparative effectiveness;Comparative Effectiveness Research;compare effectiveness;Complex;Computerized Medical Record;Consensus;Coupled;Credentialing;Data;Data Element;data management;data quality;Data Set;data standards;Databases;design;Disabilities experience;disability;Disabling condition;Documentation;effective therapy;Effectiveness;Effectiveness of Interventions;empowerment;Ensure;Environment;evidence base;Evidence based practice;Evidence based treatment;Exhibits;experience;follow-up;functional independence;functional outcomes;Future;Health Care Research;Healthcare;Heterogeneity;Hospitalization;Hospitals;Impaired cognition;Impairment;improved;improved outcome;Incidence;Independent Living;Individual;Infrastructure;Injury;Inpatients;Institute of Medicine (U.S.);Intervention;Investigation;Knowledge;Length of Stay;Life;Longitudinal Studies;Measurement;Methods;Modeling;Observational Study;operation;Outcome;Participant;patient population;Patient-Focused Outcomes;Patients;Performance;Persons;Phase;physical impairment;Prevalence;Process;prospective;Provider;Randomized, Controlled Trials;Recommendation;Recovery;recruit;rehabilitation research;Rehabilitation therapy;Research;Research Personnel;Resources;Sample Size;Scoring Method;Site;Standardization;Statistical Data Interpretation;Statistical Methods;Structural Models;symposium;targeted treatment;TBI Patients;Technology;Testing;Therapeutic Effect;Time;time use;Traumatic Brain Injury;Traumatic Brain Injury recovery;treatment comparison;treatment effect;Treatment Effectiveness;treatment planning;United States National Institutes of Health;Work

PROJECT_TITLE: Comparing Treatment Approaches to Promote Inpatient Rehabilitation Effectiveness for Traumatic Brain Injury (CARE 4 TBI)


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Aging;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Sleep Research;Substance Misuse;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: The findings from this project will determine the degree to which sex and sex hormones influence alcohol effects on sleep physiology. The results will inform future interventions aimed at reducing alcohol consumption and the negative impacts of alcohol on sleep in women. Given the wide-ranging impact of sleep on other areas of function, including cognition, stress, and well-being, such an intervention will have a substantial positive impact on women’s health.

PI_NAMEs: WEAFER, JESSICA J;WHITEHURST, LAUREN  (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: 21 year old;actigraphy;Acute;Adult;Affect;Age;age effect;alcohol consequences;Alcohol consumption;alcohol effect;alcohol monitoring;alcohol use disorder;Alcohols;Area;behavioral pharmacology;Biosensor;Blood specimen;breath alcohol measurement;Cognition;Data;design;diaries;Dose;drinking;Estradiol;experience;Future;General Population;Goals;Gonadal Steroid Hormones;Heavy Drinking;Home;Hormonal;Hormones;Hour;Impairment;Infusion procedures;innovation;Intervention;Intravenous;Laboratories;life span;Luteal Phase;male;Measures;Mediating;men;Menstrual cycle;Menstruation;Monitor;Older Population;older women;Ovarian hormone;Ovulation;Participant;Patient Self-Report;Pattern;Personal Satisfaction;Pharmaceutical Preparations;Phase;Placebos;Polysomnography;poor sleep;Prevention;Progesterone;proliferative phase Menstrual cycle;rapid eye movement;REM Sleep;Reporting;reproductive;Research;Research Personnel;Risk;Saline;sedative;sensor;sex;sex cycle;Sex Differences;Sleep;sleep behavior;Sleep disturbances;sleep physiology;sleep quality;Sleeplessness;sobriety;Stress;Wakefulness;Woman;Women's Health;Wrist

PROJECT_TITLE: Sex and Sex Hormone Factors Influencing Acute Alcohol Effects on Sleep Physiology

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


ORG_CITY: PITTSBURGH

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Mitochondria are the site of essential cellular processes such as metabolism and apoptosis (controlled cell death), which are often misregulated in cancer and neurodegenerative diseases. Proper mitochondrial function depends on a robust quality control system to remove old, damaged, or mislocalized proteins. Here, I propose experiments to test how mitochondrial protein quality control systems function, which could lead to new therapeutic approaches to cancer and neurodegenerative diseases.

PI_NAMEs: WOHLEVER, MATTHEW LEE (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Affect;Aging;Apoptosis;Apoptotic;ATP Hydrolysis;ATP phosphohydrolase;Biological Assay;Biology;Cardiovascular Diseases;Cell Death;Cell Physiology;Cessation of life;conditioned fear;Encephalopathies;Excision;experimental study;Genetic;Health;Homeostasis;Homologous Gene;Human;Impairment;In Vitro;insight;Investigation;Lead;Link;Lipid Bilayers;Malignant Neoplasms;Mediating;Membrane;Membrane Fluidity;Membrane Proteins;Metabolism;Mitochondria;mitochondrial membrane;Mitochondrial Proteins;Molecular;Mutation;Neurodegenerative Disorders;novel therapeutic intervention;Outer Mitochondrial Membrane;Oxidative Phosphorylation;Physiological;Play;Process;Proteins;Proteome;Proteomics;proteostasis;Quality Control;reconstitution;Regulation;Role;Site;Structure;System;Testing;Universities;Utah;Work

PROJECT_TITLE: Mechanistic Investigation of Proteostasis at the Outer Mitochondrial Membrane

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]