NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hepatitis;Liver Disease;Substance Misuse

ORG_CITY: MAYWOOD

ORG_DEPT: SURGERY

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

PHR: Project Narrative  Alcoholic liver disease (ALD) is one of the primary causes of chronic liver disease and is largely incurable. In this project, we will define the role of a novel hexokinase in ALD. The results of this proposal could potentially provide new insight into the molecular mechanisms of ALD development.

PI_NAMEs: QIU, WEI  (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: Alcohol consumption;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcoholic steatohepatitis;Alcohols;Binding;Biological Assay;Breast Cancer Cell;cell injury;Cells;Cessation of life;chromatin immunoprecipitation;chronic alcohol ingestion;chronic liver disease;Cirrhosis;Complex;Development;disabled;Energy-Generating Resources;Enzymes;Ethanol;feeding;Foundations;Glucose;glucose metabolism;Glycogen;Glycolysis;Grant;Hepatocyte;hexokinase;Hexokinase A;Human;Hypoxia;Impairment;insight;Knockout Mice;Lead;Literature;Liver;Liver Cirrhosis;liver injury;liver metabolism;Metabolic;Mitochondria;Modeling;Molecular;Mus;mutant;National Institute on Alcohol Abuse and Alcoholism;novel;novel therapeutic intervention;overexpression;Oxidative Phosphorylation;Oxygen;Pathogenesis;Patients;Phosphorylation;Phosphotransferases;Play;PPAR gamma;Process;Production;promoter;Rattus;Reaction;Regulation;repaired;Research;Role;Sampling;Testing;treatment strategy;United States

PROJECT_TITLE: Defining the role of a novel hexokinase in alcoholic liver disease

STUDY_SECTION: AA

STUDY_SECTION_NAME: Biomedical Research Study Section[AA-1]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Pediatric;Pediatric Cancer;Radiation Oncology;Rare Diseases

ORG_CITY: NASHVILLE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Carbon-ion radiation therapy (CIRT) has the potential to improve survival of adult patients with radioresistant brain tumors due to its physical dose distributions and its high linear-energy transfer, making it possible to treat brain cancer using less radiation dose than x rays or protons. However, for younger pediatric patients undergoing critical stages of brain development, the question shifts: what are the risks of functional neurotoxic and other late side effects? This critical and unanswered question is addressed by systematically quantifying the 1) RBE for CIRT-mediated normal-tissue toxicity in a rodent model of pediatric brain and 2) efficacy for CIRT in a preclinical rodent model of pediatric glioma.

PI_NAMEs: ELEY, JOHN G. (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Acute;Address;Adult;Anatomy;behavior test;Biological;Biological Assay;Biology;biophysical properties;Blood Vessels;Brain;Brain Neoplasms;Cancer Patient;cancer risk;Carbon ion;carbon ion therapy;Central Nervous System;Central Nervous System Neoplasms;Cessation of life;Charge;Childhood;Childhood Brain Neoplasm;Childhood Central Nervous System Neoplasm;Childhood Glioma;Chronic;Clinical;clinical practice;clinically relevant;Cognitive;Complex;Control Groups;Cranial Irradiation;Data;density;Development;disorder control;DNA Damage;Dose;efficacy evaluation;Electrons;experience;Exposure to;Foundations;Fright;Genetic Diseases;Glioma;Heterozygote;high-LET heavy ion therapy;High-LET Radiation;human disease;Immune response;Immunocompetent;Immunohistochemistry;Impaired cognition;improved;In Vitro;in vivo;in vivo imaging;Induced Mutation;insight;interdisciplinary approach;ionization;Knowledge;Laboratories;Late Effects;life span;Linear Energy Transfer;Link;Low Dose Radiation;Malignant - descriptor;Malignant Childhood Neoplasm;Malignant neoplasm of brain;Malignant neoplasm of central nervous system;Malignant Neoplasms;Mediating;Methods;millimeter;Modality;Modeling;Monitor;mosaic analysis;Mus;neurogenesis;neuroinflammation;Neurologic;Neurosciences;neurotoxic;Normal tissue morphology;novel therapeutics;Outcome;Outcome Assessment;particle;particle therapy;Pathologic;Patients;PDGFRA gene;Pediatric Neoplasm;pediatric patients;physical property;Physics;pre-clinical;Pre-Clinical Model;Property;Protons;Radiation;radiation carcinogenesis;Radiation Dose Unit;Radiation Oncology;radiation risk;Radiation therapy;radioresistant;recombinase-mediated cassette exchange;Relative Biological Effectiveness;Research;response;Risk;Rodent Model;Roentgen Rays;Second Primary Cancers;side effect;Solid Neoplasm;sound;Testing;Therapeutic;Tissues;Toxic effect;TP53 gene;Treatment outcome;treatment risk;tumor;tumor growth;Tumor Tissue;Uncertainty;United States National Aeronautics and Space Administration;Variant;white matter damage;Work;X-Ray Therapy

PROJECT_TITLE: Optimizing Carbon Ion Therapy for Pediatric CNS Tumors

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD);Substance Misuse;Women's Health Research

ORG_CITY: ATLANTA

ORG_DEPT: PSYCHIATRY

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Epidemiological evidence shows that women are more prone to developing posttraumatic stress disorder (PTSD) and have more detrimental health complications from using alcohol compared to men. While many studies have sought to understand alterations in threat neurocircuitry that define PTSD, few studies have examined the human reward neurocircuitry that underlies the development of these co-occurring disorders in women. In this proposal, utilizing ecological momentary assessment and functional neuroimaging techniques, I will determine the differences in the underlying reward neurocircuitry that promote alcohol use in trauma-exposed women.

PI_NAMEs: HINOJOSA, CECILIA A (contact)

PROGRAM_OFFICER_NAME: BALAKATHIRESAN, NAGARAJA SETHURAMAN

PROJECT_TERMS: addiction;alcohol consequences;Alcohol consumption;alcohol craving;alcohol effect;alcohol use disorder;Applications Grants;Award;Behavior;Bilateral;Biological;Black American;Brain;Clinic;Clinical;Collection;Complex;Consumption;Corpus striatum structure;Cross-Sectional Studies;Data;Data Analyses;Development;Diagnosis;Disease;Dopamine;dual diagnosis;Ecological momentary assessment;Educational workshop;empowerment;Ensure;Epidemiology;ethnic minority population;experience;Face;Faculty;Functional Magnetic Resonance Imaging;Funding;Future;Goals;Health;Healthcare;Human;human subject;Individual;Knowledge;Laboratories;Learning;Maintenance;Measures;Mediating;Mediation;meetings;men;Mentors;mid-career faculty;Minority Groups;Minority Women;Modeling;multimodal neuroimaging;National Institute of Mental Health;neural;neural circuit;neural correlate;neuroimaging;Neurologic;neuromechanism;neuropsychiatry;novel;Nucleus Accumbens;Participant;Pathway interactions;Pattern;Persons;Physician Executives;Population;Positioning Attribute;post-trauma;Post-Traumatic Stress Disorders;Pre-Clinical Model;Predisposition;Prefrontal Cortex;preventive intervention;problem drinker;Psychiatry;Publications;racial minority population;Research;Rewards;Role;Services;Severities;sex;Sex Differences;skills;smartphone application;Statistical Data Interpretation;Statistical Models;Students;Study Subject;Symptoms;Techniques;tenure track;Testing;Training;Trauma;trauma exposure;underrepresented minority student;United States;United States National Institutes of Health;Universities;Woman;women versus men

PROJECT_TITLE: Sex differences in reward neurocircuitry underlying alcohol craving and consumption in trauma-exposed individuals

STUDY_SECTION_NAME: Neuroscience and Behavior Study Section[AA-4]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_CITY: IOWA CITY

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed research is relevant to public health because of the enormous burden of disease resulting from traumatic brain injury (TBI) with over 2 million individuals suffering from TBI each year. TBI is a leading cause of death and disability, and currently, there are no specific therapies. Determining the mechanisms by which type I interferon activated microglial impact TBI may identify a novel therapeutic target for this devastating disease.

PI_NAMEs: NEWELL, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: AWWAD, HIBAH OMAR

PROJECT_TERMS: Acute;Adult;Affect;Antigen Presentation;Automobile Driving;Brain;Brain Injuries;Brain region;brain tissue;burden of illness;Cause of Death;CD8-Positive T-Lymphocytes;Cells;chemokine;Childhood;Chronic;Chronic Phase;cognitive function;CXCL10 gene;cytotoxic CD8 T cells;Data;Dendritic Cells;Detection;Development;disability;Disease;effective therapy;experimental study;Flow Cytometry;fluid percussion injury;Functional disorder;Gene Expression;Genes;glial activation;Goals;Histocompatibility Antigens Class I;Histologic;Hour;IFNAR1 gene;Immune;Impaired cognition;Impairment;improved;In Situ;Individual;Inflammation;Inflammatory;Injury;interest;Interferon alpha;Interferon Type I;Interferons;Invaded;Knockout Mice;Lateral;Leukocytes;Measures;Mediating;Messenger RNA;Microglia;middle age;Modeling;Molecular;mouse genetics;Mus;Myelogenous;Nerve Degeneration;Nervous System Physiology;Nervous System Trauma;neurobehavioral;neurobehavioral test;Neurocognitive;neuroimaging;neuroinflammation;Neurologic Dysfunctions;neuron loss;Neuronal Injury;Neurons;neuropathology;neuroprotection;neurotoxicity;new therapeutic target;novel therapeutics;Pathway interactions;pharmacologic;Pharmacological Treatment;Phenotype;Population;PTPRC gene;Public Health;Publishing;Quantitative Reverse Transcriptase PCR;receptor;recruit;Regulation;repaired;Research;Resolution;response;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Source;Supporting Cell;T-Lymphocyte;TBI Patients;TBI treatment;Testing;Therapeutic;therapeutic target;Time;Tissues;Transcriptional Activation;transcriptome;translational barrier;Trauma;Traumatic Brain Injury;treatment strategy;white matter;Work

PROJECT_TITLE: Mechanisms of type I interferon neuropathology following traumatic brain injury

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Networking and Information Technology R&D (NITRD);Pediatric;Prevention;Primary Health Care;Social Determinants of Health;Telehealth

ORG_CITY: CHENNAI

ORG_COUNTRY: INDIA

ORG_FIPS: IN

ORG_NAME: SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH TRUST

PHR: Project Narrative Innovative and socially scalable approaches are urgently needed to prevent Early Childhood Caries (ECC). We seek to develop a first-of-its-kind interactive mobile dental app that will provide age appropriate oral health related anticipatory guidance to parents/caregivers by sending out motivational alerts tailored to infant's age and stage of development addressing specific changes in oral health. The proposed approach is prevention focused and thereby highly rewarding and cost-effective compared to the traditional invasive strategies that target the burden of ECC in low- and middle- income countries.

PI_NAMEs: DHAR, VINEET K.;MURUGAN, MUTHU SATTA (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Abscess;Address;Adherence;Affect;Age;Android;arm;Articulation;Awareness;Behavior;behavior change;Behavioral;beneficiary;Calibration;Caregivers;Caries prevention;Caring;Cellular Phone;Child;Child Health;Childhood;Chronic Disease;cleft lip and palate;Clinical Trials;cohort;Communication;Control Groups;cost effective;cost effective intervention;Country;Data;density;Dental;Dental caries;Dental Hygiene;Dentists;design;Detection;Development;Diet;digital health;digital technology;Disease;early childhood;Early identification;Effectiveness;effectiveness evaluation;effectiveness testing;evidence base;experimental arm;Fathers;feeding;Fluorides;Focus Groups;follow-up;Fostering;geographic inaccessibility;Goals;Government;group intervention;Guidelines;Health;Health behavior;health belief;Health Care Costs;health determinants;Health education;health empowerment;Health Personnel;Health system;Health Technology;high reward;improved;Incidence;India;Infant;innovation;interest;International;Intervention;Interview;Knowledge;Left;Literature;London;low and middle-income countries;lower income families;Malnutrition;Mastication;Measures;medical services inaccessibility;Methods;mHealth;mhealth interventions;mobile application;Modeling;Mothers;Motivation;motivational enhancement therapy;novel strategies;Oral;oral care;Oral health;Outcome Measure;Pain;Parents;Participant;Patient Education;pediatrician;Perception;Performance;Persons;Phase;pilot test;Planning Theory;poor sleep;Prevalence;prevent;Prevention;primary outcome;Probability;Protocols documentation;prototype;Qualitative Research;Quality of life;Randomized, Controlled Trials;recruit;Registries;Reporting;Research;Research Methodology;satisfaction;Schools;Scientist;secondary outcome;self esteem;sleep behavior;social;social exclusion;Speech;Structure;success;System;telehealth;Telephone;Testing;Text Messaging;Theoretical model;Thinking;Time;tool;tooth surface;treatment adherence;usability;user-friendly;Validation;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Innovative mHealth Intervention providing Sustained Anticipatory Guidance (Zero Cavity): Design, Validation, User Perception, and Effectiveness


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Genetics;Hematology;Human Genome;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_CITY: Columbus

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: B. PROJECT NARRATIVE This project studies the cancer genetics of human acute myelogenous leukemia. The overarching goal of this proposal is to delineate genetic and genomic contributors that are currently missing in clinical risk stratification tools and in the growing landscape of potential druggable and disease-modifying targets. Our results will inform the needed complexity of clinical genetic testing panels, inclusive genetic risk assessment tools and identify exemplars of thus-far unrecognized leukemic drivers.

PI_NAMEs: EISFELD, ANN-KATHRIN  (contact);GRIMES, H. LEIGHTON;MARDIS, ELAINE R

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Affect;African ancestry;Algorithms;American;Architecture;Archives;Assessment tool;Biological;Biological Assay;Biological Testing;Biology;cancer genetics;Cell surface;Cells;chemotherapy;Classification;Clinical;Clinical Pathways;clinical practice;clinical risk;Clonality;cohort;Cytogenetics;Data;Disease;DNA Resequencing;driver mutation;drug development;European;European ancestry;Exhibits;exome;exome sequencing;FLT3 gene;Frequencies;Gene Mutation;Genes;Genetic;genetic panel test;Genetic Risk;genetic risk assessment;Genetic Transcription;Genetically Engineered Mouse;Genome;genomic profiling;Genomics;Genotype;Goals;Human;Human Genetics;in vivo;in vivo evaluation;Incidence;Knowledge;leukemia;leukemic stem cell;leukemogenesis;Malignant Neoplasms;Medical Genetics;Modality;Modeling;Molecular;multimodality;multiple omics;mutant;Mutate;Mutation;novel;Oncogenic;Open Reading Frames;Outcome;Patients;Population;precision oncology;Prediction of Response to Therapy;Prognosis;prognostic;Prognostic Marker;prognostic significance;Publications;Publishing;Recurrence;Relapse;Residual Neoplasm;Resistance;response;Risk;Risk Adjustment;risk stratification;RNA analysis;RNA Splicing;Role;Sampling;Somatic Mutation;Testing;Therapeutic;therapy development;tool;transcriptome sequencing;treatment response;treatment stratification;tumor progression;Variant;XCL1 gene;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Towards an inclusive genomic risk classification for acute myeloid leukemia  (AML)

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Networking and Information Technology R&D (NITRD);Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: WORCESTER

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Young people with HIV in Zambia often have difficulty taking medication as prescribed, miss medical appointments, and drink excessive alcohol and use other drugs. This project will develop and implement a multi-component, mHealth intervention designed to improve HIV self-management and reduce substance use. If successful, this intervention can improve the health of those affected by HIV/AIDS and reduce future rates of HIV infection in Zambia.

PI_NAMEs: MACDONELL, KAREN ;WANG, BO  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Acceleration;acceptability and feasibility;Address;Adherence;Adult;Affect;Africa South of the Sahara;Age;age group;alcohol and other drug;Alcohol consumption;Alcohols;antiretroviral therapy;Appointment;Behavior;Behavioral;binge drinking;Biological Markers;Caring;Clinic;Cognitive;Communities;community advisory board;comorbidity;computerized;Continuity of Patient Care;Counseling;Development;Disease;Dose;Drug usage;effective intervention;Effectiveness;efficacy trial;emerging adult;emerging adulthood;Epidemic;Evidence based intervention;feasibility research;Focus Groups;Future;group intervention;Health;Health behavior;Health Personnel;Health system;Healthcare;HIV;HIV Infections;HIV/AIDS;HIV/STD;improved;Infection;innovation;Intervention;intervention refinement;Interview;Link;marijuana use;medical appointment;medication compliance;men;mHealth;mhealth interventions;mobile computing;Monitor;Motivation;motivational enhancement therapy;multi-site trial;multiphase optimization strategy;NIH Program Announcements;Outcome;participant retention;Patient Recruitments;Pattern;Persons;Pharmaceutical Preparations;Phase;pilot test;pilot trial;post intervention;Prevalence;Protocols documentation;Randomized;recruit;reduced substance use;Resource-limited setting;response;Risk;Risk Behaviors;Risk Taking;satisfaction;Self Management;Services;sexual risk behavior;skills;Social Change;social stigma;Social support;Substance abuse problem;substance use;System;Testing;Text Messaging;therapy adherence;therapy design;transmission process;Treatment Efficacy;usability;Viral Load result;Woman;Work;World Health Organization;Youth;Zambia

PROJECT_TITLE: Adapting mHealth interventions to improve self-management of HIV and substance use among emerging adults in Zambia

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Mental Health;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Sleep Research

ORG_CITY: EUGENE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF OREGON

ORG_STATE: OR

PHR: PROJECT NARRATIVE Early attention and behavior problems predict a wide range of psychological disorders yet little is known about how these problems emerge very early in development. We will study prenatal and early developmental origins of sleep problems to predict emergence of attention and behavior problems in the first year of life. This will provide valuable clinical information about how to intervene to prevent the emergence of early attention and behavior disorders and improve infant and caregiver sleep.

PI_NAMEs: CONRADT, LIZ D;CROWELL, SHEILA E. (contact)

PROGRAM_OFFICER_NAME: KING, ERIN MICHELE

PROJECT_TERMS: actigraphy;Adult;Affect;Arousal;Attention;Behavior;Behavior Control;Behavior Disorders;Behavioral;Behavioral Mechanisms;Biogenesis;Birth;Caregivers;caregiving;Categories;Child;Child Behavior;Child Behavior Disorders;Childhood;Clinical;cost;Data;design;Development;Devices;Diagnosis;Diagnostic;diaries;disease classification;Disruptive Behavior Disorder;Distress;early childhood;Early Intervention;emotion dysregulation;emotion regulation;Emotional;Enrollment;Environmental Risk Factor;Exposure to;Failure;Family;Foundations;Funding;Goals;Grant;Health;Health behavior;Home;Hospitals;Hour;improved;infancy;Infant;Informal Social Control;innovation;Laboratories;Life;life span;longitudinal design;Measures;Mediating;Mental disorders;Monitor;Mothers;neurobehavior;neurobehavioral;neurodevelopment;Newborn Infant;Outcome;Pathway interactions;Pattern;Phenotype;poor sleep;postnatal;Pregnancy Trimesters;prenatal;prenatal exposure;prevent;Problem behavior;Process;Protocols documentation;Psychopathology;Questionnaires;Research;Risk;Risk Behaviors;Risk Reduction;Role;Second Pregnancy Trimester;sex;Sleep;sleep difficulty;Sleep Disorders;Sleep disturbances;sleep regulation;Structure;Surveys;Techniques;Testing;theories;Third Pregnancy Trimester;Time;Toddler;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Identifying risk earlier: Prenatal exposures, neurodevelopment, and infant sleep as pathways to toddler attention and behavior dysregulation

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: HS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_CITY: NEW HAVEN

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative This project would provide the first nationally representative estimates of Americans’ experiences with and concerns about diagnostic safety in outpatient settings. Deploying a set of innovative survey methods, data about patient experiences will be collected from 3,300 households to generate a more inclusive, complete and balanced portrait of the contemporary state of diagnostic safety in American healthcare. Using this data, the project team will then assess the impact of health system fragmentation on the prevalence and consequences of diagnostic mishaps, leveraging these results to predict potential benefits from addressing three aspects of fragmentation to improve diagnostic safety and equity in the future.

PI_NAMEs: SCHLESINGER, MARK J (contact)

PROGRAM_OFFICER_NAME: COSBY, KAREN

PROJECT_TITLE: Patient-Reported Diagnostic Safety Events in Ambulatory Care Settings: A National Survey of Systemic Influences, Disparities and Persisting Consequences


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Immunotherapy;Precision Medicine;Women's Health Research

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because 1) we will identify clinically relevant biomarkers that are involved in JNK’s immunological regulation of the tumor microenvironment (TME) in triple-negative breast cancer (TNBC) and that reflect the immunosuppressive status of the TNBC TME, and 2) we will develop an optimal effective JNK inhibitor-based immunotherapy for patients with TNBC. The long-term goal of the proposed project is to improve the survival of TNBC patients by developing a novel combination of immunochemotherapy with a JNK inhibitor that induces a TME favorable for enhancing the antitumor efficacy of immunochemotherapy. Therefore, this work is relevant to the NCI’s mission “to support cancer research across the nation to advance scientific knowledge and help all people live longer, healthier lives.”

PI_NAMEs: UENO, NAOTO T. (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;aggressive breast cancer;anti-cancer research;anti-PD1 antibodies;Biological Markers;biomarker identification;Breast Cancer Patient;CCL2 gene;Cells;chemotherapy;Clinical;clinical translation;clinically relevant;Combination immunotherapy;Combined Modality Therapy;cytokine;Data;Development;Goals;humanized mouse;Immune;immune checkpoint blockade;Immune response;Immuno-Chemotherapy;Immunocompetent;Immunohistochemistry;Immunologics;immunoregulation;Immunotherapy;improved;kinase inhibitor;Knowledge;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;MAPK8 gene;MAPK9 gene;Mediating;Mission;molecular subtypes;mouse model;Myelogenous;N-terminal;Neoplasm Metastasis;neoplastic cell;neutrophil;novel;novel marker;Outcome;Paclitaxel;Pathway interactions;patient derived xenograft model;Patient-Focused Outcomes;Patients;Persons;Phosphotransferases;potency testing;pre-clinical;Prediction of Response to Therapy;predictive marker;Production;Prognosis;Protein Isoforms;Public Health;recruit;Relapse;Research;Resistance;response;response biomarker;Sampling;Scientific Advances and Accomplishments;Signal Transduction;single-cell RNA sequencing;standard of care;synergism;targeted agent;Testing;therapeutic biomarker;therapeutically effective;Tissue Microarray;treatment strategy;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;Tumor Tissue;Tumor-associated macrophages;tumor-immune system interactions;Work

PROJECT_TITLE: Developing a novel combination immunotherapy for triple-negative breast cancer

STUDY_SECTION: ATA

STUDY_SECTION_NAME:
Advancing Therapeutics A Study Section
[ATA]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Bioengineering;Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Hepatitis;Liver Disease;Lymphatic Research;Nanotechnology;Substance Misuse

PHR: NARRATIVE  Patients with alcohol-associated liver disease (ALD) can develop severe alcoholic hepatitis (AH), carrying a very poor prognosis. Hepatic lymphatics are thought to reduce the inflammatory response by discharging excess fluids and inflammatory mediators from the liver to lymph nodes, and thus may help to ameliorate AH. The goal of this proposed study is to explore the potential of enhancing liver lymphatic drainage as a novel therapeutic strategy for AH.

PI_NAMEs: IWAKIRI, YASUKO  (contact)

PROGRAM_OFFICER_NAME: WANG, JOE

PROJECT_TERMS: Address;Alcohol abuse;Alcohol consumption;alcohol effect;Alcoholic Hepatitis;Alcoholic Liver Diseases;Alcohols;Antigen-Presenting Cells;Antigens;California;Cell Physiology;Cell surface;cholangiocyte;Cholestasis;Chronic;chronic alcohol ingestion;Cirrhosis;Clinical;clinically relevant;Collaborations;Consumption;Development;Diet;Encapsulated;Endothelial Cells;Ethanol;Exhibits;experimental study;Extravasation;feeding;Foundations;Future;gain of function;Gene Expression;Goals;Hepatic;Hepatocyte;Hybrids;IL7 gene;Impairment;in vivo;Inflammation;Inflammation Mediators;Inflammatory Response;Infusion procedures;lipid nanoparticle;Liquid substance;Liver;Liver diseases;liver inflammation;liver injury;loss of function;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic drainage;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;Lymphatic System;lymphatic vessel;Mesothelial Cell;Messenger RNA;Modeling;Molecular;Mus;novel;novel therapeutic intervention;overexpression;Pathologic;patient subsets;Patients;Pennsylvania;Phenotype;Population;Prognosis;Protocols documentation;Regulation;Reporter;Role;single-cell RNA sequencing;Structure;Technology;Testing;Tissues;transcriptomics;Universities;Vascular Endothelial Growth Factor C;western diet

PROJECT_TITLE: Hepatic lymphatics in alcohol-associated liver disease


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Opioid Misuse and Addiction;Opioids;Social Determinants of Health;Substance Misuse

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF DELAWARE

ORG_STATE: DE

PHR: PROJECT NARRATIVE People with opioid use disorder are trapped in a deadly cycle wherein opioid use leads to social isolation, and social isolation leads to increased risk of continued opioid use and overdose. Disclosure can reduce social isolation and help people (re-)establish social connection as they enter and engage in treatment; however, many people in recovery from opioid use disorder struggle with disclosure decisions and processes. We propose to test whether a disclosure intervention designed to help people receiving treatment for opioid use disorder make disclosure decisions and build disclosure skills leads to improved treatment- and recovery-related outcomes.

PI_NAMEs: EARNSHAW, VALERIE ANN (contact)

PROGRAM_OFFICER_NAME: ZUR, JULIA BETH

PROJECT_TERMS: acceptability and feasibility;addiction;Address;Behavioral Model;Capital;Characteristics;Chronic Disease;Clinical;Communication;Complex;coping;Coping Skills;Data;Death Rate;Decision Aid;Decision Making;Delaware;design;Disclosure;efficacy evaluation;efficacy study;Environment;Evidence based intervention;experience;follow-up;Goals;Growth;HIV;Hour;illicit opioid;improved;Individual;innovation;Intervention;intervention effect;Mediating;Mediation;Mediator;Medical Records;Medicine;Mental disorders;Modeling;National Institute of Drug Abuse;opioid overdose;opioid use;opioid use disorder;Outcome;overdose death;overdose risk;Participant;Pathway interactions;Persons;Phase;pilot test;prevent;Process;psychobiologic;Psychologist;Quality of life;Randomized;Randomized, Controlled Trials;Recommendation;Recording of previous events;Recovery;Reporting;Research;response;Rest;Risk;Science;Series;skills;sobriety;social;social attachment;Social Facilitation;Social isolation;social stigma;Social support;Specialist;Stigmatization;Surveys;Testing;therapeutic target;therapy design;therapy development;United States;United States National Institutes of Health;Waiting Lists;Withdrawal

PROJECT_TITLE: Disclosure Intervention to Reduce Social Isolation and Facilitate Recovery among People in Treatment for Opioid Use Disorder

STUDY_SECTION: SPIP

STUDY_SECTION_NAME: Social Psychology, Personality and Interpersonal Processes Study Section[SPIP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Contraception/Reproduction;Estrogen;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: Narrative Understanding the molecular processes by which the cervix undergoes a remarkable remodeling through pregnancy from closed and rigid to compliant for safe delivery is critical for defining causes of premature remodeling in preterm birth and for the identification of biomarkers to assess risk of prematurity as well as therapies for prevention. The purpose of this study is to understand how synthesis, assembly, and degradation of cervical collagen and elastic fibers is altered during pregnancy to impact mechanical function and regulated by steroid hormones in clinically relevant animal models. The knowledge gained from these studies has the potential to (1) identify clinically-relevant pathways that can be targeted for prevention of preterm birth and (2) identify new mechanical parameters to diagnose cervical dysfunction associated with preterm birth.

PI_NAMEs: MAHENDROO, MALA S. (contact);MYERS, KRISTIN MARIE

PROGRAM_OFFICER_NAME: GIRARDI, GUILLERMINA

PROJECT_TERMS: Acceleration;Animal Model;Automobile Driving;biglycan;Biology;biomarker identification;Biomechanics;Birth;Birth Rate;Cell Culture System;Cervical;cervical remodeling;Cervical Ripening;Cervix Incompetence;Cervix Uteri;Clinical;clinically relevant;Collagen;Collagen Fiber;Collagen Fibril;crosslink;Data;decorin;Defect;Degradation Pathway;density;Diagnosis;Elastic Fiber;Elastin Fiber;Ensure;Equilibrium;Estrogen Therapy;Estrogens;Event;extracellular;Extracellular Matrix;FBLN5 gene;FBN1;Fetus;Fibrillar Collagen;Functional disorder;Genetic;Genetic Transcription;Homeostasis;Human;Inflammation;Inflammatory;insight;Intervention;Investigation;Knockout Mice;Knowledge;Length;Leucine;Lifelong disability;Maintenance;Measures;mechanical properties;Mechanics;Mediating;Metabolism;Metalloproteases;Modality;Modeling;Molecular;mortality risk;mouse model;Multiscale Mechanics;Mus;Mutation;novel;Ovariectomy;Pathway interactions;Peptide Hydrolases;Phase;Physiological;Post-Translational Protein Processing;Postpartum Period;posttranscriptional;Pregnancy;pregnant;premature;Premature Birth;Premature Infant;Prevention;Prevention therapy;Process;Progesterone;programs;Property;Proteoglycan;Proteomics;Regulation;repaired;resilience;Risk;Risk Assessment;Role;spatiotemporal;steroid hormone;Stromal Cells;Structural defect;Structure;Structure-Activity Relationship;Testing;Tissues;tool;Woman;Work

PROJECT_TITLE: Molecular and Mechanical Investigations to Define Collagen and Elastic Fiber Homeostasis in Cervical Remodeling During a Term and Preterm Pregnancy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-C(02)M]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: BIRMINGHAM

ORG_DEPT: ADMINISTRATION

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative This project proposes a framework for mitigating the emergency department (ED) overcrowding problem. The project is relevant to public health as it improves patient flow in EDs and consequently reduces waiting times and ED boarding time and increases bed utilization and ED throughput. Improving such outcomes should reduce the likelihood of medical errors, enhance patient safety, and increase patient satisfaction.

PI_NAMEs: AHMED, ABDULAZIZ  (contact);OZAYDIN, BUNYAMIN

PROGRAM_OFFICER_NAME: MICHAELS, MARIA

PROJECT_TITLE: Building and Implementing a predictive decision support system based on a proactive full capacity protocol to mitigate emergency overcrowding problem

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: NARRATIVE The Southwest Transformative Educational Advancement and Mentoring network brings together four Minority Serving Institutions across the US Southwest: University of New Mexico, New Mexico State University, Northern Arizona University, and Burrell College of Osteopathic Medicine to train the next generation of scientists in cancer and cancer health disparities. This network aims to foster the development of underrepresented and diverse scientists and investigators and strengthen the career pipeline for pre- and post-doctoral trainees and Early Stage Investigators. This proposed network will enhance the capacity of the scientific workforce to address cancer and cancer health disparities experienced by diverse populations in the Southwest United States.

PI_NAMEs: GUEST, DOLORES  (contact);JIMENEZ, ELIZABETH ;SUSSMAN, ANDREW LOUIS

PROGRAM_OFFICER_NAME: BARFIELD-STEWARD, WHITNEY

PROJECT_TERMS: Achievement;Address;anti-cancer research;Arizona;cancer health disparity;career;Classification;college;community engagement;demographics;Development;doctoral student;Education;education research;Educational Curriculum;Eligibility Determination;Employment Opportunities;Enrollment;Ensure;ethnic minority population;experience;falls;Fostering;Funding;Geography;Goals;Health;Health Disparities Research;health disparity;higher education;Hispanic;improved;Institution;Link;Malignant Neoplasms;Mentors;Mentorship;minority communities;Minority Groups;Minority-Serving Institution;multimodality;National Cancer Institute;New Mexico;next generation;Occupations;Osteopathic Medicine;peer coaching;Persons;Population;Population Heterogeneity;post-doctoral training;Postdoctoral Fellow;Poverty;pre-doctoral;Productivity;Professional Competence;programs;racial minority population;Research;Research Activity;Research Personnel;Resources;Role;role model;Science;Scientist;Site;skills;skills training;Southwestern United States;Students;symposium;System;Talents;Technical Expertise;tool;Training;Training and Education;training opportunity;Underrepresented Minority;Underserved Population;United States;Universities;web platform;web site;webinar

PROJECT_TITLE: Southwest Transformative Educational Advancement and Mentoring (STEAM) Network

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


FUNDING_MECHANISM: SBIR-STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Liver Cancer;Liver Disease;Orphan Drug;Rare Diseases

ORG_CITY: San Jose

ORG_NAME: FILTRO MEDICAL INC.

ORG_STATE: CA

PHR: PROJECT NARRATIVE We propose a paradigm shift in cancer therapy: ChemoFilter, an endovascular catheter-based medical device that will be inserted under image guidance into the veins of the body to directly filter specific chemotherapy drugs out of the blood stream after these drugs have had their effect on a tumor but before they have caused systemic toxic effects. ChemoFilter would help patients fight cancer by minimizing drug toxicity, allowing for high-dose therapy to better treat their disease and improve survival. Patients suffering from primary and oligometastatic liver cancers are the first targets for this device.

PI_NAMEs: HETTS, STEVEN WILLIAM (contact)

PROGRAM_OFFICER_NAME: EVANS, GREGORY

PROJECT_TERMS: Achievement;Anatomy;Animal Model;Animal Testing;Antineoplastic Agents;Arteries;Binding;Biodistribution;Biological Assay;biomaterial compatibility;Blood;Blood Circulation;Blood coagulation;Blood flow;Blood Vessels;Businesses;Cancer Etiology;cancer therapy;Catheters;cell killing;Cessation of life;Chemoembolization;chemotherapeutic agent;chemotherapy;Chemotherapy-Oncologic Procedure;Clinical;Clinical Trials;comparison control;Consumption;cost;Deposition;design;design,build,test;Device Designs;Devices;Disease;Disease remission;Distant;dosage;Dose;Dose Limiting;Doxorubicin;Drug Targeting;Drug toxicity;efficacy study;efficacy testing;Engineering;Enrollment;Excision;experience;Extracorporeal Dialysis;Family suidae;fighting;Filtration;first-in-human;Future;Goals;Heart;Heart failure;Hemodialysis;hemodynamics;hepatic vein;Histology;Human;image guided;implantable device;improved;In Situ;In Vitro;in vivo;in vivo evaluation;Individual;Infusion procedures;interest;Interventional radiology;Liquid substance;Liver;liver cancer patient;Liver neoplasms;Location;Malignant neoplasm of liver;Malignant Neoplasms;Measures;mechanical properties;Mechanics;Medical;Medical Device;Metabolism;Metastatic Neoplasm to the Liver;minimally invasive;Minor;Modeling;Modification;mortality;Motivation;Myocardium;neoplastic cell;Organ;Pathway interactions;Patients;Perforation;Pharmaceutical Preparations;Phase;Phlebography;Plasma;Population;porcine model;pre-clinical;prevent;Primary Malignant Neoplasm of Liver;Procedures;prototype;Qualifying;Randomized, Controlled Trials;response;Rest;Safety;safety study;Saline;side effect;Site;Small Business Technology Transfer Research;Solid;standard of care;Stream;success;systemic toxicity;Systemic venous structure;Techniques;Technology;Testing;Therapeutic;Thrombosis;Time;Toxic effect;Toxicity due to chemotherapy;Translating;tumor;Unresectable;Veins;Vena caval structure;Venous;Venous Pressure level;Work

PROJECT_TITLE: Endovascular ChemoFilter to Reduce Doxorubicin Toxicity during Intra-Arterial Chemotherapy


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Machine Learning and Artificial Intelligence

ORG_DEPT: PHYSICS

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The threat posed by Gram-negative bacteria is significant and growing due to the spread of antibiotic resistance. Infection by these pathogens is often mediated by virulence factors known as autotransporter proteins. This project will determine the atomic-level details of autotransporter folding and expression, thus providing a basis for novel antibacterial interventions.

PI_NAMEs: GUMBART, JAMES C. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Adhesions;Amino Acids;Anti-Bacterial Agents;Antibiotic Resistance;Atomic Force Microscopy;B-Lymphocytes;Bacterial Adhesins;base;beta barrel;beta pleated sheet;Biological Assay;Bordetella pertussis;C-terminal;Cell surface;Cessation of life;Chemicals;Chicago;Classification;Collaborations;Complex;Coupling;crosslink;Cryoelectron Microscopy;cytotoxic;Data;deep learning;deep learning model;Deuterium;Diffusion;Electrostatics;Environment;Escherichia coli;Exhibits;experimental study;extracellular;Extracellular Space;Free Energy;functional hypothalamic amenorrhea;Goals;Grain;Gram-Negative Bacteria;Gram-Negative Bacterial Infections;Growth;Hybrids;Hydrogen;In Vitro;in vivo;Individual;Infection;Infection Control;innovation;Intervention;Kinetics;laboratory experiment;Mass Spectrum Analysis;Mediating;member;Membrane;Methodology;Methods;Modeling;Molecular;molecular dynamics;molecular scale;N-terminal;Names;non-Native;novel;pathogen;pathogenic bacteria;Pathogenicity;Pathway interactions;Peptide Hydrolases;periplasm;pertactin;Porosity;Positioning Attribute;prevent;priority pathogen;Process;Protein Export Pathway;Protein Secretion;Proteins;Rationalization;Research;Resistance development;Side;simulation;small molecule;Structure;Surface;System;Testing;Time;tool;Tracheal Epithelium;Validation;Virulence;Virulence Factors;World Health Organization;Yersinia pestis

PROJECT_TITLE: Elucidating the mechanisms of protein secretion across the outer membrane by bacterial autotransporters

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: NARRATIVE: OVERALL: Mapping the Cancer Complex System from Clinical MR Imaging of GBM The aim of our Mayo/Columbia CSBC Mathematical Oncology Systems Analysis Imaging Center (MOSAIC) is to build a conceptual framework to understand sex-specific glioma tissue state transitions and dynamics and the ways to interpret MRI relative to those changes MOSAIC leverages a large and growing core unique resource of radiographically-localized biopsies in glioma patients. In two projects, we will employ quantitative systems biology to quantify the dynamic glioma tissue state ecosystem and connections to routine clinical imaging. This will allow us to better understand glioma tissue states, their cellular cross-talk and how individual patients’ tissue state landscape will respond to therapy to ultimately drive new clinical trials that improve patient outcomes.

PI_NAMEs: CANOLL, PETER ;SWANSON, KRISTIN R (contact)

PROGRAM_OFFICER_NAME: DUECK, HANNAH RUTH

PROJECT_TERMS: Admixture;Affect;Age;Anatomy;Arizona;Atlas of Cancer Mortality in the United States;Bioinformatics;biological heterogeneity;Biology;Biopsy;Brain;Brain Neoplasms;brain parenchyma;Cell Nucleus;Cells;Classification;Clinic;Clinical;clinical imaging;Clinical Oncology;clinical translation;Clinical Trials;cohort;Collaborations;Communities;Complex;Computer Models;Dendritic Cell Vaccine;density;Detection;Diagnostic;Disease;Disease Progression;diversity and inclusion;driving force;Ecosystem;Evolution;Fostering;Future;Genetic;Glioblastoma;Glioma;Heterogeneity;Image;image archival system;Image Guided Biopsy;imaging facilities;imaging modality;Immunotherapy;improved;in vivo;in vivo imaging;Incidence;individual patient;Inflammation;insight;Inter-tumoral heterogeneity;lens;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of brain;Malignant Neoplasms;Maps;mathematical model;Mathematics;Medical;men;Methods;Modeling;Molecular Analysis;Molecular Biology;Monitor;neoplastic;novel;Oncology;Operative Surgical Procedures;Organ;outreach;Patient Care;Patient-Focused Outcomes;Patients;Pattern;Persons;Phenotype;Physicians;Physics;Population;precision medicine;precision oncology;predictive modeling;radiological imaging;recruit;Research;Resources;response;Scientist;Series;sex;sex as a biological variable;Sex Bias;Signal Transduction;soft tissue;standard of care;System;Systems Analysis;Systems Biology;T-Lymphocyte;Therapeutic;Tissue Sample;Tissues;Training;transcriptome sequencing;treatment response;tumor;tumor growth;tumor microenvironment;tumor progression;Universities;Vaccine Therapy;Vision


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Rare Diseases

PHR: NARRATIVE: ADMINISTRATIVE CORE The Administrative Core will be the primary touchpoint of the center, facilitating interactions between the two projects and three additional cores. The Administrative Core will also actively cultivate collaborations throughout the consortium with assistance from the Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse perspectives on this critical topic. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business, administrative and scientific management of Center activities.

PI_NAMEs: SWANSON, KRISTIN R (contact)

PROJECT_TERMS: Administrator;Advisory Committees;Area;Authorization documentation;Award;Biopsy;Businesses;career;clinical imaging;Collaborations;Communication;Communities;Core Biopsy;Data;data access;data exchange;data integration;data management;data sharing;Discipline;Educational workshop;Ensure;Evaluation;Faculty;Feedback;Funding;Glioma;Grant;Growth;Image;imaging facilities;Institution;Institutional Review Boards;interest;Leadership;Logistics;Machine Learning;Magnetic Resonance Imaging;Malignant Neoplasms;Mathematics;meetings;Monitor;neuro-oncology;Office of Administrative Management;Oncology;outreach;Pathology;Patients;Phenotype;Pilot Projects;Process;programs;Publications;Radiology Specialty;recruit;Regulation;Reproducibility;Research Project Grants;Resource Sharing;Resources;Suggestion;symposium;Systems Analysis;Systems Biology;Tissues;training opportunity;Visit;web site;Work

PROJECT_TITLE: MOSAIC: Administrative Core


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Neurosciences;Rare Diseases

PHR: NARRATIVE: PROJECT 1: TARGETING GLIOMA TISSUE STATES Glioblastoma (GBM) biopsies are composed of not only molecularly aberrant malignant glioma cells but also a sizeable abundance of non-malignant cells (including immune, astrocytes, oligodendrocytes, etc.). The goal of this project is to find targetable cross-talk relationships between these cell compositional networks. Specifically, we will quantify different cellular compositions in pre- and post- treatment tumors, investigate cross-talk between the glioma cells and the microenvironmental other cell subpopulations, and, lastly, determine the impact of targeting this crosstalk to shift the cell community composition into a more favorable/treatable state.

PI_NAMEs: CANOLL, PETER  (contact)

PROJECT_TERMS: Acute;Aftercare;anti-PD-L1;Astrocytes;Biological;Biopsy;Bone Marrow;Brain;cell behavior;cell community;Cell Nucleus;Cell Physiology;Cell Proliferation;Cells;Chemoresistance;Conditioned Culture Media;cytokine;Disease Progression;effective therapy;Endothelial Cells;Extracellular Matrix;Genomics;Glioblastoma;Glioma;Goals;Heterogeneity;Image;imaging facilities;Immune;Immunocompetent;Immunotherapy;In Vitro;in vivo;Infiltration;Inflammatory;insight;Interleukin-10;Interleukin-6;Ligands;Macrophage;Magnetic Resonance Imaging;male;Malignant Glioma;Mathematics;Mediating;member;Mesenchymal;Microglia;Modeling;Molecular;Mutation;Myeloid Cells;neoplastic cell;Neurons;Non-Malignant;novel therapeutic intervention;Oligodendroglia;Oncology;Patients;Pattern;Pericytes;Phenotype;Population;progenitor;radiological imaging;receptor;receptor expression;Receptor Inhibition;recruit;Regimen;Role;Sampling;Signal Pathway;Signal Transduction;single nucleus RNA-sequencing;Slice;Systems Analysis;T-Lymphocyte;temozolomide;Testing;Therapeutic;therapy resistant;Tissues;TNF gene;transcriptome sequencing;Translations;treatment response;tumor;tumor growth;tumor initiation;tumor microenvironment;Tumor Necrosis Factor Receptor;tumor progression;Tumor Promotion;women patients;Xenograft Model

PROJECT_TITLE: MOSAIC: Targeting the Tissue State


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention;Women's Health Research

ORG_CITY: LOS ANGELES

ORG_NAME: LOYOLA MARYMOUNT UNIVERSITY

PHR: Project Narrative Sexual minority women disproportionately consume alcohol, suffer from alcohol-related problems, and experience depression and anxiety. Although clinical programs are being developed for sexual minority women seeking treatment, culturally tailored preventive interventions able reduce alcohol consumption and increase psychological well-being in the larger at-risk population not motivated to seek treatment have been slow to emerge. This project narrows the disparity in alcohol intervention research and practice by advancing a highly scalable, culturally adapted, gamified personalized normative feedback alcohol intervention able to engage non-treatment seeking sexual minority women and reduce their alcohol and mental health risks.

PI_NAMEs: BOYLE, SARAH C;LABRIE, JOSEPH W. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: alcohol abuse therapy;Alcohol consumption;alcohol intervention;alcohol prevention;alcohol related problem;alcohol use disorder;Alcohols;Anxiety;Baseline Surveys;Behavior;Bisexual;Cellular Phone;Characteristics;Clinical;Communities;Consumption;coping;Coping Behavior;design;digital intervention;Disparity;drinking;drinking behavior;Effectiveness;Effectiveness of Interventions;effectiveness/implementation trial;experience;Feedback;follow-up;Fostering;Future;gender minority group;health disparity populations;Heavy Drinking;Heterosexuals;high reward;improved;Incentives;Individual;interest;Intervention;Intervention Studies;Lesbian;Life Style;Loneliness;Mechanics;Mediator;Mental Depression;Mental Health;Methods;online community;Outcome;Participant;Pathway interactions;peer;personalized normative feedback;pilot trial;Polishes;Population;Populations at Risk;preventive intervention;programs;psychoeducation;psychologic;queer;Randomized;Randomized, Controlled Trials;recruit;Research;Resources;Risk;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority health disparity;sexual minority women;Shame;social;social competition;social media;social stigma;Social support;Stereotyping;Stigmatization;Surveys;Testing;Topical application;United States National Institutes of Health;Well in self;Woman

PROJECT_TITLE: Feasibility and Effectiveness of Gamified Digital Intervention to Prevent Alcohol and Mental Health Risks


NIH_SPENDING_CATS: Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

PHR: NARRATIVE: PROJECT 2: IMAGING THE DYNAMIC TISSUE STATE IN PATIENTS IN VIVO Magnetic resonance imaging (MRI) measures many different physical properties of the tissue which may be correlated with the specific tumor behavior (e.g., proliferation, inflammation, angiogenesis) found in the limited biopsies available per patient. This project will fuse readily available MRI to spatially localized biopsies to build predictive models of cellular composition across the unsampled tumor (and brain) to track and validate cell composition changes to standard and immune therapies. Connecting these imaging changes to patient survival will allow identification of clinically beneficial shifts in cellular cohabitation.

PROJECT_TERMS: Adult;angiogenesis;Automobile Driving;Biological Markers;Biopsy;Brain;Brain Neoplasms;Cell model;Cells;Clinical;clinical imaging;cohort;cost;Diagnosis;Disease;Disease Progression;Epidermal Growth Factor Receptor;Facility Accesses;Genomic Segment;Glioblastoma;Glioma;Guidelines;Human;human imaging;human tissue;Image;Image Analysis;imaging facilities;Immune;Immune response;Immune Targeting;Immunocompetent;Immunooncology;Immunotherapy;immunotherapy clinical trials;improved;in vivo;individual patient;individualized medicine;Inflammation;Inflammatory;Magnetic Resonance Imaging;Malignant - descriptor;Mathematics;Measures;Mediating;Modeling;Molecular;Monitor;Nature;neoplastic cell;noninvasive diagnosis;novel;Oncology;Outcome;patient safety;Patient-Focused Outcomes;Patients;Phenotype;physical property;Physiological;Population;predictive modeling;Primary Brain Neoplasms;Proliferating;quantitative imaging;radiomics;Recurrence;Residual Neoplasm;Resources;response;Sampling;Signal Transduction;standard of care;Study models;Systems Analysis;Therapeutic;Time;Tissue Model;Tissue Sample;Tissues;tool;Treatment Protocols;treatment response;tumor;tumor behavior;Work

PROJECT_TITLE: MOSAIC: Imaging Human Tissue State Dynamics In Vivo


NIH_SPENDING_CATS: Bioengineering;Brain Cancer;Brain Disorders;Cancer;Neurosciences;Precision Medicine;Rare Diseases

PHR: NARRATIVE: OUTREACH CORE Getting computational results into the clinic requires a broader understanding of the methods and general principles by scientists, clinicians, and patients alike. Thus, the primary goal of the Outreach Core is to disseminate knowledge of the iterative dialogue between mathematical oncology, cancer systems biology and experimental and clinical oncology to students, colleagues, and the general public. To accomplish our goal, we will train new cross-disciplinary scientists, inform the research community, engage with the general public, and assess our outcomes.

PI_NAMEs: JACKSON, PAMELA ROSE (contact)

PROJECT_TERMS: Advocacy;Arizona;Awareness;Biological;Biological Sciences;Biology;Brain Neoplasms;Cancer Biology;cancer education;Cell Physiology;Clinic;Clinical;clinical imaging;Clinical Oncology;clinical translation;Collaborations;Communities;Complex;Computational Science;Consent;design;Discipline;Disease;Education and Outreach;Educational workshop;Engineering;Ensure;experience;Exposure to;Facebook;Family;Future;General Population;Genetic;Glioblastoma;Goals;graduate student;Image;imaging facilities;improved;individual patient;innovation;Institution;Internships;Journals;Knowledge;Language Development;large datasets;Malignant Neoplasms;mathematical learning;mathematical methods;mathematical model;Mathematics;Methodology;Methods;Modeling;neuro-oncology;next generation;novel strategies;Oncology;Outcome;Outcome Assessment;Output;outreach;outreach program;patient advocacy group;Patient Care;Patients;personalized medicine;Postdoctoral Fellow;programs;recruit;Research;Research Project Grants;Scientist;skills;social media;Social Network;Solid;Students;success;summer research;symposium;System;Systems Analysis;Systems Biology;Techniques;Tissues;tool;Training;Twitter;undergraduate student;Universities;Update;web site;Work

PROJECT_TITLE: Outreach Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Neurosciences;Rare Diseases

PHR: NARRATIVE: BIOSPECIMEN CORE The Biospecimen Core will assist the Center through two specific aims: Aim 1) collect and store biopsies, Aim 2) run initial tissue characterization of immunohistochemistry and sequencing. The duties of the Biospecimen Core Mayo Clinic Arizona (MCA) and Columbia University Medical Center (CUMC) and will support both projects. The data generated by the Biospecimen Core will be transferred to the Data Integration and Computation Core, where it will be stored, further processed including batch correction and atlas alignment, and integrated into computational modeling tools.

PROJECT_TERMS: Academic Medical Centers;Aftercare;Arizona;Atlases;Biology;Biopsy;Cell Lineage;Cells;Clinic;Clinical;Complex;Computer Models;Consent;Data;data integration;Detection;Freezing;gene panel;Glioblastoma;Glioma;Goals;Histologic;Histology;Image;Image Guided Biopsy;imaging facilities;Immunohistochemistry;in vivo;machine learning model;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;mathematical model;Mathematics;Mission;Modeling;Molecular;Molecular Analysis;Oncogenes;Oncology;Operative Surgical Procedures;Paraffin Embedding;Pathology;Patients;Phenotype;Process;radiological imaging;recruit;RNA;Running;Sampling;Scanning;single cell sequencing;single-cell RNA sequencing;Site;Slide;Subgroup;System;Systems Analysis;Tissue imaging;tissue preparation;Tissue Stains;Tissues;tool;Training;transcriptome sequencing;treatment response;Validation

PROJECT_TITLE: MOSAIC: Biospecimen Core


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Chronic Pain;Interstitial Cystitis;Neurosciences;Pain Research;Urologic Diseases

ORG_CITY: RICHARDSON

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF TEXAS DALLAS

PHR: PROJECT NARRATIVE  Patients suffering from urologic chronic pelvic pain syndrome (UCPPS) in the form of interstitial cystitis/bladder pain syndrome (IC/BPS) or chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) have an extremely poor quality of life due, in part, to the cognitive and emotional problems that accompany their pelvic pain and a lack of effective treatments. To learn more about the brain’s role in bladder pain in the hopes of finding new therapeutic targets, we focus on the amygdala, a brain area involved in both pain and emotion. These proposed studies will investigate the role of the left versus right amygdala in contributing to and altering bladder pain in mice.

PI_NAMEs: KOLBER, BENEDICT J (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: 3-Dimensional;Absence of pain sensation;Acute;Affect;affective disturbance;Amygdaloid structure;Analgesics;Anatomy;Animal Model;Anxiety;Area;Behavior;behavior test;Bladder;Bladder Control;Bladder Injury;bladder pain;Brain;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;cell type;Cells;Central Nervous System;Chronic;chronic pelvic pain;Chronic Prostatitis;Clinical;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;Cognitive;Complex;Computer Models;Data;Development;Disease;effective therapy;Electrophysiology (science);Emotional;Emotions;experimental study;Failure;Foundations;Goals;gray matter;Heterogeneity;Human;human model;Hyperalgesia;Hypersensitivity;in vivo calcium imaging;Injury;innovation;insight;Interstitial Cystitis;knock-down;Laboratories;Language;Learning;Left;Limbic System;Location;Maintenance;Measures;Mediating;Mediator;Messenger RNA;Modeling;Molecular;Mus;Neurons;Neuropeptides;new therapeutic target;Nociception;novel;optogenetics;Output;Pain;pain chronification;Pain Disorder;pain model;Pathologic;Pathway interactions;Patients;Pelvic Pain;Peptide Signal Sequences;Peripheral;Peripheral Nervous System;Persistent pain;Physiological;Physiology;Play;Population;pre-clinical;prevent;Production;Quality of life;Recovery;Regulation;Research;response;Rodent Model;Role;Sensory;Side;Slice;Stress;Structure of terminal stria nuclei of preoptic region;Substantia Innominata;Symptoms;Syndrome;Testing;three-dimensional modeling;Time;time use;treatment site;urologic;urologic chronic pelvic pain syndrome;Viscera;Visceral pain;visual processing;Work;zona incerta

PROJECT_TITLE: Impact of Amygdala Lateralization on Processing and Modulation of Bladder Pain

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Rare Diseases

PHR: NARRATIVE: DATA INTEGRATION AND COMPUTATION CORE The Data Integration and Computation Core will be central to our Mayo/Columbia CSBC Mathematical Oncology Systems Analysis Imaging Center (MOSAIC), collecting the diverse data types and sources and providing infrastructure for data resource management of the large datasets relied upon and generated through the center including those provided by the Biospecimen Core. The Data Integration and Computation Core will support both projects with its three aims: Aim 1) collect and store data across all sites, Aim 2) provide reproducible bioinformatics workflows, and Aim 3) provide computational modeling tools and techniques.

PI_NAMEs: WILSON, MELISSA A (contact)

PROJECT_TERMS: Authorization documentation;Bioinformatics;Biopsy;Calibration;Cancer Patient;Clinical;Clinical Data;clinical imaging;Clinical Research;Code;Collection;Computer Models;Data;data access;data infrastructure;data integration;Data Management Resources;data sharing;Data Sources;demographics;digital;digital data;Disease;diverse data;Ensure;Generations;genomic data;Glioma;Histology;Home;Hybrids;Image;imaging facilities;imaging Segmentation;in vivo;Infrastructure;innovation;Institution;Institutional Review Boards;large datasets;Location;Machine Learning;machine learning model;Magnetic Resonance Imaging;Malignant neoplasm of brain;Mathematics;Measurement;Mission;model development;Modeling;Molecular;Oncology;Online Systems;Outcome;Pathology;Patients;predictive modeling;Process;Reporting;repository;Reproducibility;Resources;response;Scanning;Secure;Services;sex as a biological variable;single-cell RNA sequencing;Site;Source;Specimen;Statistical Data Interpretation;Statistical Models;Structure;success;support tools;Systems Analysis;systems research;Techniques;Texture;Tissues;tool;tumor;Work

PROJECT_TITLE: MOSAIC: Data Integration and Computation Core


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Emergency Care;Health Services;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: SPRINGFIELD

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

PHR: PROJECT NARRATIVE  The increasing morbidity and mortality of the opioid epidemic has necessitated a reevaluation of current addiction treatment paradigms: medications for opioid use disorder, such as buprenorphine and methadone, are effective in decreasing one’s risk of death and disability from opioid use but are underutilized and often difficult to access. The 5000 Emergency Departments (EDs) in the US are potential additional locales for medication initiation, but currently only a small minority of ED patients with opioid use disorder are started on medications. This R34 will refine and pilot an intervention called Talk About It which aims to foster patient-centered care, ‘meet patients where they are’ for addiction treatment, and increase treatment initiation and adherence via facilitating Shared Decision-Making in the ED around these potentially life-saving options.

PI_NAMEs: SCHOENFELD, ELIZABETH MAE (contact)

PROGRAM_OFFICER_NAME: MARTIN, LINDSEY ANN

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;addiction;Address;Adherence;American;arm;Attitude;Buprenorphine;Caring;Clinical Data;clinical decision-making;clinical outcome assessment;Clinical Trials;Collection;college;Communication;Communities;Compassion;Data;design;disability;Disease;distrust;Drug Prescriptions;Educational Intervention;Effectiveness;Eligibility Determination;Emergency Care;Emergency Department patient;Emergency Department Physician;Empathy;Enrollment;Ensure;Evaluation;experience;Feedback;Fostering;Frequencies;Future;Goals;Grant;Health;health equity;implementation science;improved;in vivo;innovation;instrument;Intervention;Interview;Knowledge;Life;Link;Lived experience;Locales;medication for opioid use disorder;Medicine;Methadone;Minority;Minority Groups;Morbidity - disease rate;mortality;mortality risk;Multicenter Trials;multidisciplinary;novel;Opioid;opioid epidemic;opioid mortality;opioid overdose;opioid use;opioid use disorder;Outcome;participant enrollment;Pathway interactions;patient oriented;Patient Outcomes Assessments;patient retention;Patient-Centered Care;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;pilot trial;Policies;primary outcome;Procedures;prospective;Protocols documentation;Provider;Qualitative Methods;Randomized, Controlled Trials;Readiness;Recommendation;Recovery;Reporting;Research;Research Project Grants;secondary outcome;Self Efficacy;shared decision making;Site;social stigma;Structure;Testing;therapy design;tool;Training;treatment adherence;Treatment outcome;Trust;United States;uptake

PROJECT_TITLE: Conversations can save lives: TALKing About Buprenorphine & methadone for Opioid Use Treatment Initiation (TALK ABOUT)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Immunotherapy;Orphan Drug;Rare Diseases;Women's Health Research

PHR: PROJECT NARRATIVE Breast cancer response to treatments strongly depends on the composition of the local tumor microenvironment. This project will determine if targeting the epidermal growth factor receptor (EGFR) in inflammatory breast cancer can shift the tumor microenvironment from immunosuppressive to immunoreactive. Results of our study will have broad implications for tumors that have thus far been insensitive to immune checkpoint inhibitors.

PROJECT_TERMS: Adjuvant Chemotherapy;Animal Cancer Model;anti-cancer;anti-PD-L1 antibodies;Antitumor Response;breast cancer genomics;Breast Cancer Model;Breast Cancer Patient;CCL2 gene;CCL20 gene;Cell Proliferation;Cell Survival;checkpoint inhibition;chemokine;chemotherapy;Clinical;Clinical Research;Clinical Trials;clinically relevant;Color;Combination immunotherapy;combinatorial;Combined Modality Therapy;CXCL5 gene;Cytotoxic T-Lymphocytes;Data;Development;efficacy testing;Epidermal Growth Factor Receptor;Failure;Fc Receptor;Flow Cytometry;Genetic Transcription;genomic data;Histologic;humanized mouse;IL8 gene;Immune checkpoint inhibitor;Immune system;Immunocompetent;immunoreactivity;Immunotherapy;In complete remission;in vitro Assay;in vivo;Infiltration;Inflammatory;inflammatory breast cancer;Macrophage;Malignant Breast Neoplasm;Malignant Neoplasms;mouse model;Neoadjuvant Therapy;neoplastic cell;new therapeutic target;novel;panitumumab;Pathologic;Pathway interactions;patient response;Patients;Phase II Clinical Trials;Phenotype;preclinical study;predicting response;prevent;Receptor Inhibition;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Research;Research Personnel;Resistance;Role;single-cell RNA sequencing;targeted treatment;Testing;Therapeutic;therapeutic target;Tissue Microarray;Tissues;transcription factor;treatment response;triple-negative invasive breast carcinoma;tumor;tumor growth;tumor microenvironment;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Development of a novel therapy targeting the tumor microenvironment in inflammatory breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Immunotherapy;Infectious Diseases;Lymphatic Research;Orphan Drug;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: LA JOLLA

ORG_DEPT: OTOLARYNGOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Narrative Cancer immunotherapies have led to major treatment breakthroughs for a number of different cancers, but the majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. We have demonstrated that targeting tumors with stereotactic radiation in combination with immunotherapy while sparing draining lymphatics enhances anticancer immunity, resulting in significantly improved response profiles. The research outlined in this proposal will leverage targeted tumor radiation and a combination of anti-CD47 and anti-PD-1 therapy to improve the response to PD-1 inhibitor immunotherapy in human papilloma virus related cancers of the throat.

PI_NAMEs: CALIFANO, JOSEPH A (contact)

PROGRAM_OFFICER_NAME: VIKRAM, BHADRASAIN

PROJECT_TERMS: Ablation;Adjuvant;Adjuvant Therapy;anti-cancer;Anti-CD47;anti-PD-1;anti-PD1 therapy;antigen-specific T cells;Architecture;arm;Attenuated;Automobile Driving;B-Lymphocytes;Beds;Biological Models;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;CD4 Positive T Lymphocytes;CD47 gene;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Adhesion;Cells;chemokine;chemoradiation;chemotherapy;Clinical;Clinical Trials;Clone Cells;Common Terminology Criteria for Adverse Events;cytotoxic CD8 T cells;Cytotoxic Chemotherapy;Data;Dependence;design;Disease-Free Survival;Dose;draining lymph node;Enteral Feeding;Excision;Frequencies;head and neck cancer patient;Head and Neck Squamous Cell Carcinoma;Heterogeneity;HPV oropharyngeal cancer;HPV positive;Human Papilloma Virus-Related Malignant Neoplasm;Immune;immune activation;immune checkpoint blockade;immune function;Immunocompetent;Immunologic Surveillance;Immunotherapy;improved;In complete remission;Incidence;Infiltration;inhibitor;irradiation;lymph nodes;Lymphatic;Malignant Neoplasms;Measures;Metastatic/Recurrent;Morbidity - disease rate;Neck Dissection;Neoadjuvant Therapy;Nivolumab;Nodal;novel;Operative Surgical Procedures;Outcome;Pathologic;Patients;PD-1 inhibitors;pembrolizumab;Phase;Phase I Clinical Trials;phase I trial;phase II trial;pre-clinical;Pre-Clinical Model;preservation;Primary Neoplasm;programmed cell death protein 1;Quality of life;Radiation;Radiation therapy;Radioimmunotherapy;Randomized;Research;Resectable;response;Risk;Safety;Sentinel Lymph Node;standard of care;Structure of germinal center of lymph node;T cell clonality;T cell infiltration;T-Lymphocyte;Therapeutic;Throat Cancer;Toxic effect;Treatment Protocols;trial comparing;tumor;tumor ablation;Tumor Antigens;Tumor Expansion;Tumor Immunity;Tumor Volume;United States;Up-Regulation

PROJECT_TITLE: Neoadjuvant immunoradiotherapy for HPV mediated oropharynx cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TIR-W(01)Q]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Electronic Nicotine Delivery Systems;Mental Health;Prevention;Sleep Research;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: NARRATIVE Electronic cigarettes (e-cigarettes) are one of the most widely used tobacco products and a growing number of people report wanting to quit using them, yet little is known about e-cigarette withdrawal and there are no proven interventions for promoting e-cigarette cessation. The goal of this project is to rigorously evaluate the nature of e-cigarette withdrawal in exclusive e-cigarette users during a monitored abstinence period and the role of nicotine in the expression of this withdrawal syndrome. The proposed project will provide essential information to the FDA and public health organizations about the clinical significance of behavioral and biological withdrawal outcomes and inform mechanisms for e-cigarette cessation.

PI_NAMEs: SPINDLE, TORY RICHARD;STRICKLAND, JUSTIN CHARLES (contact)

PROGRAM_OFFICER_NAME: HERRMANN, EVAN SULLIVAN

PROJECT_TERMS: Abstinence;actigraphy;Acute;Adult;Area;Attenuated;Behavior assessment;Behavioral;Biological;Biometry;Cigarette;cigarette smoke;cigarette smoking;Clinical;clinically significant;Cognitive;cognitive function;cognitive performance;cognitive task;combustible cigarette;craving;Data;Dependence;design;DSM-V;e-cigarette cessation;efficacy evaluation;Electroencephalography;Electronic cigarette;electronic cigarette use;electronic cigarette user;Enrollment;Evaluation;Expectancy;experience;follow-up;Fostering;Goals;Health Benefit;health organization;Health Policy;Hour;Impaired cognition;Impairment;insight;interest;Intervention;Laboratories;Measures;Monitor;Moods;Motivation;Nature;negative affect;Nicotine;Nicotine Dependence;nicotine patch;nicotine replacement;Nicotine Withdrawal;Outcome;Participant;Patients;Persons;pharmacologic;Pharmacology;Placebos;prolonged abstinence;Public Health;Regulation;Reporting;Research;return to use;Rewards;Role;Short-Term Memory;Sleep;Sleep Architecture;Sleep disturbances;sleep quality;Smoke;Smoker;smoking cessation;Smoking Cessation Intervention;Standardization;standardize measure;Substance Withdrawal Syndrome;sustained attention;Symptoms;Syndrome;Task Performances;Testing;therapy development;Tobacco;Tobacco use;Translating;vaping;virtual;Withdrawal;Withdrawal Symptom;Wrist;Youth

PROJECT_TITLE: Evaluation of the Electronic Cigarette Withdrawal Syndrome: Mechanistic Targets for Intervention

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative The use of gene sequencing technologies to detect genetic changes in cancer has improved patient care by offering novel therapies that specifically target these genes. New approaches to detect genetic changes from blood samples offer a non-invasive approach to diagnose patients with cancer in need of new therapies. In this proposal, we will develop a blood test for FGFR genes that is focused, cost-effective, accurate, and practical for real-time use to enable rapid diagnosis, therapy monitoring, resistance detection.

PI_NAMEs: ROYCHOWDHURY, SAMEEK  (contact)

PROGRAM_OFFICER_NAME: DEY, SUMANA MUKHERJEE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;assay development;Autopsy;Bioinformatics;Biological Assay;Blood specimen;Blood Tests;cancer genomics;Cancer Patient;cell free DNA;Cell Line;Cholangiocarcinoma;Clinical;Clinical Laboratory Improvement Amendments;Clinical Trials;cohort;Complex;cost;cost effective;Coupling;design;Detection;detection limit;Development;Diagnosis;diagnostic strategy;Diagnostic tests;Disease;Disseminated Malignant Neoplasm;DNA Sequence Alteration;DNA sequencing;Drug resistance;Early Diagnosis;Enrollment;Evaluation;Exclusion;expedited review;experience;FDA approved;FGFR1 gene;FGFR2 gene;Fibroblast Growth Factor Receptors;Gene Fusion;Genes;Genomic Segment;Grant;Growth Factor Receptor Genes;Heterogeneity;improved;inhibitor;kinase inhibitor;liquid biopsy;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Methods;molecular diagnostics;Monitor;Mutation;Nature;novel;novel strategies;novel therapeutics;Ohio;Patient Care;patient screening;Patients;Performance;Prognosis;Progression-Free Survivals;prospective;Qualifying;rapid detection;rapid diagnosis;Rapid diagnostics;real time monitoring;Reproducibility;Research;Resistance;Resistance development;resistance mutation;response;Retrospective cohort;ROS1 gene;Sampling;Selection for Treatments;Sensitivity and Specificity;Single Nucleotide Polymorphism;Site;Solid Neoplasm;Specific qualifier value;synthetic construct;targeted treatment;Technology;Testing;therapy development;Time;time use;tool;treatment response;tumor;Tumor Burden;Tumor Tissue;Universities;Urothelium;Validation;validation studies;variant detection;virtual;X-Ray Computed Tomography

PROJECT_TITLE: Liquid Biopsy for Rapid Detection and Real Time Monitoring of FGFR-altered Cancers


ORG_CITY: IOWA CITY

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF IOWA

PHR: Project Narrative The proposed research is relevant to public health because it focuses on the development of a new technique and device to reduce unwanted radiation dose for cancer patients undergoing proton therapy and is expected to decrease normal tissue complications and improve quality of life. The proposed research is relevant the NCI mission as it accelerates the development and application of a new technology for the fight against cancer.

PI_NAMEs: HYER, DANIEL ELLIS (contact)

PROGRAM_OFFICER_NAME: BEIER, HOPE THOMAS

PROJECT_TERMS: Acceleration;Air;Algorithms;Area;Benchmarking;Brain;Brain Neoplasms;brain tissue;Cancer Patient;care delivery;Childhood;Clinic;Clinical;clinical care;Collimator;commercialization;Computational Technique;cost;cost effective;Data;design;Development;Devices;Distal;Dose;Ensure;Equipment;Feedback;fighting;Foundations;Goals;head and neck cancer patient;Head and Neck Neoplasms;improved;in silico;Individual;Industrialization;Inferior;innovation;Intercept;Ions;Lateral;Malignant Neoplasms;Marketing;Measurement;Measures;Mechanics;Methodology;Methods;Mission;Modeling;Monitor;Motion;new technology;next generation;Normal tissue morphology;Outcome;Parents;Patients;Photons;Planning Techniques;Plant Leaves;Positioning Attribute;Predisposition;preservation;proton beam;proton therapy;Protons;prototype;Public Health;quality assurance;Quality of Care;Quality of life;Radiation Dose Unit;Radiation therapy;Radiation Toxicity;Research;Risk Reduction;Rotation;Scanning;side effect;Speed;Spottings;Surface;System;Techniques;Technology;technology platform;Testing;Time;Tissues;tool;Translating;treatment duration;Treatment Efficacy;Treatment outcome;treatment planning;tumor;Uncertainty;Validation;Work

PROJECT_TITLE: Sharpening the edge in pencil-beam proton therapy: an aftermarket collimation system to better spare normal tissue during radiation treatment


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Infectious Diseases;Machine Learning and Artificial Intelligence;Malaria;Networking and Information Technology R&D (NITRD);Prevention;Rare Diseases;Vector-Borne Diseases

ORG_CITY: KAMPALA

ORG_COUNTRY: UGANDA

ORG_FIPS: UG

ORG_NAME: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES

PHR: Our approach comprises two major innovations to automated malaria diagnosis and surveillance in Uganda: 1) the development of machine learning approaches for standardised microscopy of malaria. 2) the building of a real time field-based surveillance of malaria system

PI_NAMEs: NAKASI, ROSE  (contact)

PROGRAM_OFFICER_NAME: LASH, TIFFANI BAILEY

PROJECT_TERMS: 3D Print;Address;Africa;Artificial Intelligence;Automation;Calibration;Cellular Phone;Cessation of life;Communicable Diseases;Complement;Computer software;cost;Country;Coupling;Data Science;Data Sources;deep learning;deep learning model;design;Developing Countries;Development;Diagnosis;Diagnostic;diagnostic platform;Disease;disease diagnosis;Disease Surveillance;disorder risk;Drug resistance;Environment;Equipment;experience;field study;Goals;Health;Image;Image Analysis;implementation intervention;improved;Individual;innovation;Location;Machine Learning;machine learning method;Malaria;Malaria Diagnosis;Maps;meter;Methods;Microscope;Microscopy;Modeling;non-traditional data;novel;Outcome;pathogen;Pathogen detection;Performance;Pilot Projects;point of care;Prevention;Probability;Public Health;public health intervention;real time model;Reporting;Research;Resolution;Resources;Risk;screening;Stains;Standardization;System;Techniques;Technology;Telephone;Testing;Time;tool;Training;trend;Uganda;Universities;Update;Work

PROJECT_TITLE: Automated Mobile Microscopy for Malaria Diagnosis and surveillance in Uganda

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BTC-L(70)R]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Prevention;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Clinicians currently operate in a clinical and policy environment with no high-quality evidence supporting optimal guidelines on the perioperative care for patients on OUD who undergo surgical procedures. Using state-of-the-art national databases and rigorous methods, we will generate the most comprehensive data analyses to date on the landscape of perioperative management of buprenorphine and other MOUD as well as its consequences on opioid overdose risk and other health outcomes in privately insured, Medicaid, and Medicare patients aged 15 years and above. Findings from this proposal will inform efforts to optimize the perioperative management of buprenorphine and other MOUD, thus informing optimized perioperative efforts to reduce opioid-related morbidity and mortality for patients with OUD.

PI_NAMEs: BICKET, MARK ;NGUYEN, THUY DIEU (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: 15 year old;Acceleration;Acute;Acute Pain;addiction;Adolescent;Adverse event;Advocate;Age;age group;American;antagonist;Binding;Buprenorphine;Cessation of life;Clinical;cohort;comorbidity;Conflict (Psychology);Data;Data Analyses;Databases;Diagnosis;Dose;Emergency department visit;Environment;Euphoria;Event;experience;Expert Opinion;Failure;Formulation;Geographic Factor;Geography;Guidelines;Health;Health Care Costs;Heterogeneity;high risk;hospital readmission;Hospitalization;illicit opioid;improved;Insurance;interest;Knowledge;Knowledge Management;Length of Stay;Medicaid;medical specialties;Medicare;medication for opioid use disorder;Medication Management;Methadone;Methods;Minor;Morbidity - disease rate;mortality;Naltrexone;older adult;Operative Surgical Procedures;Opioid;Opioid agonist;Opioid Analgesics;opioid overdose;opioid use;opioid use disorder;Outcome;Overdose;overdose death;overdose risk;Pain;Pain management;pain outcome;Patient Care;patient retention;Patient-Focused Outcomes;Patients;Pattern;Perioperative;Perioperative Care;Persons;Policies;population based;Postoperative Pain;Postoperative Period;Practice Guidelines;pragmatic implementation;Predictive Factor;prescription opioid;Prevalence;prevent;Privatization;Provider;provider factors;Race;receptor;Recommendation;relapse risk;Research;respiratory;Risk Reduction;Sampling;surgical pain;treatment duration;United States;Variant

PROJECT_TITLE: The Impact of Surgery on Outcomes for Patients taking Medications for Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-HSS-B(90)S]


NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PHR: This award will provide protected time for Dr. Kerri Cavanaugh to devote specifically to developing skills and delivering mentoring in kidney disease research. Her objective is to recruit and mentor post-doctoral students as a primary mentor, and to serve as an advocacy/network mentor for pre- and post-doctoral trainees including those in graduate degree programs as well as emerging physician scientists including fellows and junior faculty, for successful research careers in kidney disease, and to support the career advancement of her current trainees. The proposal here will build on her developing skills as a mentor through dedicated training to ultimately deliver and lead multicomponent strategies to meet the needs of diverse students by leveraging her research program, aligned current leadership roles and the abundant local, regional and national resources.

PI_NAMEs: CAVANAUGH, KERRI  (contact)

PROGRAM_OFFICER_NAME: RANKIN, TRACY L

PROJECT_TERMS: Address;Adult;Advisory Committees;Advocacy;Affect;American;anti-racism;Area;Award;Basic Science;career;career development;Career Mobility;Caring;Clinical Research;Clinical Services;Clinical Trials;community engagement;Creativeness;Dedications;Degree program;Development;Disparity;doctoral student;Ensure;equity, diversity, and inclusion;Faculty;Fellowship;Foundations;Funding;Future;Geographic Locations;Goals;Graduate Degree;Health;health care delivery;health literacy;Health Services Research;Healthcare;implementation research;improved;Individual;Infrastructure;Institution;International;Investments;Kidney;Kidney Diseases;Kidney Failure;Lead;Leadership;Learning;lens;Medical center;member;Mentors;Mentorship;Mind;Mission;Modeling;Morbidity - disease rate;mortality;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;novel;novel therapeutics;Pathology;Patients;Persons;Physicians;Policy Research;poor health outcome;Populations at Risk;Postdoctoral Fellow;pre-doctoral;Process;programs;psychologic;Quality of life;recruit;Research;research faculty;Research Personnel;Research Project Grants;Research Training;Resources;Role;Science;Scientific Advances and Accomplishments;Scientist;Self Care;Shapes;skills;skills training;Societies;Source;stakeholder perspectives;Students;Teacher Professional Development;Time;Training;Translating;Translational Research;unconscious bias;Underrepresented Populations;United States National Institutes of Health;Universities

PROJECT_TITLE: Expanding Multilevel Multicomponent Mentorship in Kidney Disease Research


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Pediatric;Social Determinants of Health;Substance Misuse;Underage Drinking;Violence Against Women;Violence Research;Women's Health Research;Youth Violence

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative Alcohol use temporally increases risk for college students’ intimate partner violence (IPV) perpetration, but real-time alcohol-related IPV interventions delivered proximally to drinking episodes remain underdeveloped. As a first step toward our long-term goal of expanding just-in- time alcohol-related IPV interventions, this application will examine the feasibility and utility of objectively monitoring alcohol intoxication in relation to IPV perpetration using portable breathalyzers paired with a smartphone-based ecological momentary assessment application. This objective assessment of alcohol use in heavy drinking college students’ natural environments is a novel shift from collecting self-reported alcohol use data in relation to IPV and will inform the expansion of remotely-delivered alcohol and IPV reduction strategies in real time.

PI_NAMEs: BREM, MEAGAN JACQUELYN (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: acceptability and feasibility;Acute;adaptive intervention;Address;Adverse event;Age;Alcohol consumption;alcohol content;alcohol monitoring;Alcoholic Beverages;Alcoholic Intoxication;Alcohols;assessment application;Blood alcohol level measurement;Cellular Phone;college;college drinking;Consumption;Couples;Data;Data Collection;diaries;distilled alcoholic beverage;drinking;Ecological momentary assessment;Environment;Event;experience;Future;Gender;gender difference;Goals;Heavy Drinking;heavy drinking college student;Intervention;intimate partner violence;Intoxication;Juice;Laboratories;Limb structure;Link;men;Methods;Monitor;National Institute on Alcohol Abuse and Alcoholism;Notification;novel;novel strategies;Participant;Patient Self-Report;Population;portability;Predisposition;Procedures;Process;psychologic;Reaction;Recording of previous events;remote assessment;remote delivery;Reporting;Research;Research Personnel;Research Support;Risk;Sampling;sexual aggression;Technology;Testing;Time;undergraduate student;university student;violence perpetration;Woman;young adult

PROJECT_TITLE: Integrating Remote Breath Alcohol Monitoring into Ecological Momentary Assessment of Alcohol-Related Intimate Partner Violence among Young Adult Drinkers

STUDY_SECTION_NAME: Epidemiology, Prevention and Behavior Research Study Section[AA-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Prevention;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: AFRICA INSTITUTE OF MENTAL AND BRAIN HEALTH

PHR: PROJECT NARRATIVE The proposed project seeks to develop, pilot, and test the feasibility and preliminary efficacy of a smartphone- delivered climate adaptation safety and harm reduction intervention for women experiencing intimate partner violence (IPV) in informal settlements in Kenya using ecological momentary approaches. The project will: (1) develop, test, and modify a smartphone-based EMA application designed to collect information on female residents’ IPV experiences, emotional stress, IPV self-efficacy, receipt of IPV-related social support and services, safety, climate-related comfort, social and environmental context, and current behaviors in informal settlements (R21: Phase 1); (2) pilot test the EMA application among 320 women living in two large informal settlements in Nairobi, Kenya and use the data collected to explore important, but understudied associations between climate and IPV in informal settlements (R21: Phase 2); (3) adapt an evidence-based Wings of hope (WINGS) intervention for integration into the smartphone-based EMA application developed in the R21 phase (R33: Phase 1); and (4) test the feasibility and preliminary efficacy of the adapted WINGS-based ecological momentary intervention (EMI) through a randomized control trial (RCT) (R33: Phase 2). The goals of this study are: to provide women with a low-cost, accessible, smartphone-based tool that empowers them to develop, utilize, and revise personal safety and harm reduction strategies that are specifically responsive to climate- related IPV and, in doing so, to provide survivors with interventions in real-time.

PI_NAMEs: MUSYIMI, CHRISTINE WAYUA (contact);WINTER, SAMANTHA C.

PROGRAM_OFFICER_NAME: BEKALU, MESFIN AWOKE

PROJECT_TERMS: Anxiety;anxiety reduction;Area;assessment application;Behavior;behavior change;Behavior Therapy;behavioral response;Cause of Death;Cellular Phone;Climate;climate adaptation;climate change;climate impact;Collection;Communities;computerized;cost;Data;design;Development;digital assessment;Ecological momentary assessment;Emotional Stress;empowerment;Environment;Event;evidence base;Evidence based intervention;Exclusion;experience;extreme weather;Face;feasibility testing;Female;Floods;food insecurity;Foundations;Frequencies;Geography;Goals;Harm Reduction;Health behavior;Health Services Accessibility;Heat Waves;Household;Housing;Industrialization;Infrastructure;interpersonal conflict;Interpersonal Violence;Intervention;intimate partner violence;Kenya;Land Tenure;Legal;low and middle-income countries;low income country;marginalization;Mental Depression;Mental Health;mobile application;Modeling;Morbidity - disease rate;mortality;Outcome;Participant;participant retention;Personal Satisfaction;Persons;Phase;physical conditioning;pilot test;Politics;Population;Post-Traumatic Stress Disorders;Poverty;Precipitation;Probability Samples;Rain;Randomized;Randomized, Controlled Trials;Reporting;Research;Resources;response;Risk;Risk Reduction;Safety;Sanitation;Seasons;Secure;Self Efficacy;Services;Site;smartphone application;social;Social support;Social Work;spelling;Stress;Structure;Surveys;Survivors;Temperature;Testing;Time;tool;Violence;wasting;Water;Weather;Well in self;Wing;Woman;Women's Health;Work

PROJECT_TITLE: Development and testing of a smartphone-delivered climate adaptation and IPV and related stress intervention for residents of informal settlements in Kenya using ecological momentary approaches


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

PHR: Project Narrative Developmental retinal blood vessel formation is a complex and highly regulated process, and pathologies associated with aberrant formation or proliferation of retinal blood vessels are among the leading causes of blindness. A thorough understanding of retinal vascular development is necessary to better understand retinal vascular diseases. The proposed studies aim to understand the role of innate immunity in the regulation of retinal blood vessel development and elevate our understanding of how abnormal neovasculature arises.

PI_NAMEs: GNANAGURU, GOPALAN  (contact)

PROGRAM_OFFICER_NAME: GORDIYENKO, NATALIYA

PROJECT_TERMS: Ablation;Address;Adult;Affect;Animals;Astrocytes;Biological Assay;Birth;Blindness;blood vessel development;Blood Vessels;C3AR1 gene;CCL2 gene;CD11c Antigens;cell motility;Cell Separation;cell type;Cells;Cellular Morphology;chemokine;chemokine receptor;Complement;Complement 3a;Complement Activation;Complement Receptor;Complex;Custom;Data;design;Development;Developmental Process;Distal;Embryo;Endothelial Cells;Endothelium;Exhibits;Future;gene complementation;Gene Expression;Goals;Growth;Immune;immune activation;Immunoassay;immunoregulation;In Situ Hybridization;In Vitro;Innate Immune System;innovation;Knockout Mice;Knowledge;Ligands;Macrophage-1 Antigen;Microglia;migration;Migration Assay;Molecular;Mus;mutant;Natural Immunity;Neonatal;neovasculature;Neuroglia;new therapeutic target;novel;novel therapeutic intervention;Optic Disk;Optic Nerve;Pathology;Pattern;Phagocytosis;Phase;Physiological;Population;postnatal;Process;Proliferating;Proteins;receptor;recruit;Regulation;Reporter;Reporting;Retina;retina blood vessel structure;Retinopathy of Prematurity;Reverse Transcriptase Polymerase Chain Reaction;RNA;Role;Shapes;Signal Transduction;targeted treatment;Testing;Therapeutic;Transcript;transcriptome sequencing;Vascular Diseases;Vision

PROJECT_TITLE: Innate Immunomodulation of Retinal Vascular Development

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cardiovascular;Clinical Research;Health Services;Lung;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pulmonary Hypertension

ORG_CITY: OAKLAND

ORG_NAME: EKO DEVICES, INC.

PHR: Project Narrative Pulmonary hypertension is a complex disease that is associated with high morbidity and mortality but often missed and underdiagnosed. An accurate clinical decision support algorithm that is able to screen for and detect pulmonary hypertension will impact public health by providing earlier diagnosis, earlier access to treatment, and better patient outcomes.

PI_NAMEs: CHOUDHARY, GAURAV ;VENKATRAMAN, SUBRAMANIAM  (contact)

PROGRAM_OFFICER_NAME: XIAO, LEI

PROJECT_TERMS: Address;Adult;Algorithms;Award;Cardiac;Cardiac Catheterization Procedures;care costs;Caring;Cellular Phone;Chest;Classification;Clinical;clinical decision support;cloud software;comorbidity;Complex;cost;Data;Data Set;Databases;deep learning;deep learning algorithm;design;Detection;Diagnosis;Diagnostic;digital;Disease;Early Diagnosis;Echocardiography;Eko;Electrocardiogram;Enrollment;Evaluation;Functional disorder;Goals;Health Services Accessibility;Hospitalization;Human Resources;improved;innovation;Investigation;Label;Lead;Location;Marketing;Measures;Medical Device;Modality;Morbidity - disease rate;mortality;novel;Outcome Study;patient screening;Patient-Focused Outcomes;Patients;Performance;Personal Computers;Phase;Phenotype;point of care;pressure;Prognosis;prototype;Public Health;pulmonary arterial pressure;Pulmonary Hypertension;Quality-Adjusted Life Years;Randomized;research clinical testing;Running;screening;Screening procedure;Sensitivity and Specificity;Severities;Signal Transduction;Small Business Innovation Research Grant;Specificity;Stethoscopes;Stream;support tools;Symptoms;Tablet Computer;Testing;Time;Training;trial comparing;Validation

PROJECT_TITLE: Deep learning for algorithmic detection of pulmonary hypertension using a combined digital stethoscope and single-lead electrocardiogram