ORG_CITY: DENVER

ORG_NAME: DENVER HEALTH AND HOSPITAL AUTHORITY

PHR: PROJECT NARRATIVE Severely injured children have better health outcomes when they are transported to high-level trauma centers. Current national field trauma triage guidelines, which have been widely adopted by emergency medical services (EMS) systems nationally, do not accurately identify children in need of trauma center resources. We will describe the potential health impact of accurate field triage through a descriptive analysis of undertriage of children in 7 states using AHRQ Healthcare Cost and Utilization (HCUP) databases, derive and validate refined pediatric field triage using predictive modeling of a robust population-based dataset, and conduct a mixed methods study evaluating implementation outcomes of the refined criteria in an urban EMS system, with the ultimate goal of matching injury severity with appropriate resources to improve patient outcomes.

PI_NAMEs: MCCORMICK, TAYLOR  (contact)

PROGRAM_OFFICER_NAME: WILLIS, TAMARA

PROJECT_TITLE: Improving Pediatric Field Trauma Triage

STUDY_SECTION: HCRT

STUDY_SECTION_NAME: Healthcare Research Training [HCRT]


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Mental Health

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The proposed T32 fellowship program is designed to train psychiatrists and clinical PhDs to formulate original research questions on etiology, pathogenesis, course, treatment and prevention of serious mental illness, with a focus on patients with schizophrenia and major mood disorders. Each trainee, paired with a mentor, will formulate a career development plan with targeted goals for acquisition of skills, presentations, publications, gathering pilot data, and preparation of proposals for independent research funding. We aim to help fill the dearth in clinical neuroscientists so that the recent advances in neuroscience can be translated into better care for the millions of patients with serious mental illness.

PI_NAMEs: KAHN, RENE S. (contact);NEW, ANTONIA S;PEREZ RODRIGUEZ, MARIA DE LAS MERCEDES

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Clinical;next generation;Training

PROJECT_TITLE: Training the next generation of clinical neuroscientists


ADMINISTERING_IC: HS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: AGENCY FOR HEALTHCARE RESEARCH AND QUALITY

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative: The prevalence of type 2 diabetes (T2D) has grown to epidemic proportions and is largely considered one of the most significant public health problems in the US. While a great deal of effort has been spent assisting primary care providers in delivering guideline-concordant care to achieve glycemic control, less has been spent facilitating patient's perspective of their disease into care—creating a paramount need to make patient-reported data actionable and meaningful to patients and providers alike. Combining ubiquitous health information technology solutions such as the mobile phone and electronic health record with state-of-the-art artificial intelligence-supported tools could create a dynamic and scalable solution that is seamlessly integrated into care to support patients with T2D and their providers in attaining improvements in patient-reported and clinical outcomes and, in doing so, enabling efficient delivery of high-quality patient-centered care in primary care settings.

PI_NAMEs: MANN, DEVIN M;SCHOENTHALER, ANTOINETTE M (contact)

PROGRAM_OFFICER_NAME: PATEL, SHEENA

PROJECT_TITLE: iMatter2: An AI-driven approach to supercharge a novel digital patient-reported outcomes tool for diabetes management

STUDY_SECTION: HITR

STUDY_SECTION_NAME: Healthcare Information Technology Research[HITR]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Inter-hospital transfer of patients with critical illnesses like acute respiratory failure (ARF)—by ground or by air—is a common and costly practice in the U.S. critical care system despite a limited evidence base for its efficacy in improving outcomes and unknown cost-effectiveness. The proposed study will use commercial insurance and Medicare claims data to characterize national use patterns for inter-hospital transfer of the broad population of critically ill adult patients; estimate the effect on mortality of air compared to ground transfer of patients with ARF using a novel instrumental variables approach that takes advantage of random weather conditions; and perform a rigorous cost-effectiveness analysis of the use of air compared to ground inter-hospital transfer of patients with ARF. The results of this research will provide physicians, health systems, insurers, and governments with actionable evidence to inform decisions, resource allocation, and policy surrounding inter-hospital transfer within the U.S. critical care system.

PI_NAMEs: WORSHAM, CHRISTOPHER MOORE (contact)

PROJECT_TITLE: Use of Inter-Hospital Transfer Services in Critical Illness and Acute Respiratory Failure


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The American Cancer Society estimates that in 2022 there will be over 1.9 million new cancer cases diagnosed and over 600,000 cancer deaths. The Stanford Cancer Imaging Training (SCIT) Program trains new generations of researchers and physician scientists to become cutting-edge investigators working at the intersection of medical imaging and disciplines such as engineering, artificial intelligence, chemistry, cancer biology, physiology, and informatics. Through the SCIT program, we promote advancing clinical applications of image- based techniques for better cancer detection and treatment, which will, in turn, drive down cancer mortality and morbidity.

PI_NAMEs: DAHL, JEREMY  (contact);DANIEL, BRUCE L

PROGRAM_OFFICER_NAME: DAMICO, MARK W

PROJECT_TERMS: cancer imaging;Training Programs

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: LEXINGTON

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Defining how mRNA transferring mediates the platelet-cancer cell interaction will fill a critical gap in our knowledge about the intercellular communication during cancer progression. Elucidating the mechanism by which CD9 regulates platelet mRNA transferring will significantly expand our understanding about cell fusion in the platelet-cancer cell interaction and help to identify a potential therapeutic target to suppress the platelet- induced cancer progression and metastasis. The study of platelet PF4 mRNA in regulating cancer cell stemness will reveal a chemokine regulation pathway and new roles of PF4 in cancer cell colonization.

PI_NAMEs: XU, REN  (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: Affinity Chromatography;Binding Proteins;Biological Assay;Biology;Blood Platelets;Breast Cancer Cell;breast cancer progression;cancer cell;cancer genetics;Cancer Patient;carcinogenesis;Cell Communication;Cell fusion;Cell Physiology;Cells;chemokine;Co-Immunoprecipitations;Communication;Complex;confocal imaging;CXC Chemokines;CXCR4 gene;CXCR4 Receptors;cytokine;Cytokine Activation;Data;Distant;extracellular vesicles;Family;gain of function;Galectin 3;Genes;Genetic Engineering;genetic signature;Hematogenous;human data;in vivo;Incidence;inhibitor;insight;intercellular communication;Knockout Mice;Knowledge;loss of function;Malignant Breast Neoplasm;Malignant Neoplasms;Mediating;Membrane Fusion;Membrane Proteins;Messenger RNA;Microfluidic Microchips;MicroRNAs;Molecular;mouse model;mRNA delivery;multidisciplinary;Neoplasm Circulating Cells;Neoplasm Metastasis;neoplastic cell;novel;novel strategies;Organ;Pathway Analysis;Pathway interactions;PF4 Gene;Play;Population;Positioning Attribute;Primary Neoplasm;protein complex;Proteins;recruit;Recurrence;Regulation;Research;Ribosomes;Role;screening;Signal Transduction;small molecule;Small RNA;stemness;Stromal Cell-Derived Factor 1;Testing;therapeutic target;tissue culture;Tissues;transcriptome sequencing;Translating;Translations;tumor progression

PROJECT_TITLE: Roles of mRNA Transfer in Cancer Cell-Platelet Communication

STUDY_SECTION: TEHM

STUDY_SECTION_NAME: Tumor Evolution, Heterogeneity and Metastasis Study Section[TEHM]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: ROCHESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: This proposal uses multidisciplinary approach to investigate role of activated platelets to promote atherogenic processes in persons with HIV by interacting with monocyte and releasing micro-RNA and proteins encapsulated platelet-derived microparticles. This study holds strong prospects to significantly improve aging related comorbidities in persons living with HIV in general and atherosclerosis in particular.

PI_NAMEs: SINGH, MEERA VIR;THAKAR, JUILEE  (contact)

PROGRAM_OFFICER_NAME: ZOU, SHIMIAN

PROJECT_TERMS: Acceleration;Affect;aging related;antiretroviral therapy;Arterial Fatty Streak;Atherosclerosis;Binding;Biology;Blood Platelets;Blood Vessels;Cardiovascular Diseases;cardiovascular disorder risk;Carotid Artery Plaques;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;chemokine;Cholesterol;Chronic;Clinical Research;Clinical Sciences;comorbidity;Complex;Computational Biology;Computer Models;cytokine;Data;Deposition;Disease;early detection biomarkers;Encapsulated;Endothelial Cells;epidemiology study;Event;Exhibits;experimental study;FCGR3B gene;Feedback;Foam Cells;Gene Expression;Genes;Genetic Transcription;Health Status;HIV;HIV Infections;HIV-1;Human;Image;immune activation;immunosenescence;improved;Individual;Infection;Inflammation;Inflammatory;innovation;interdisciplinary approach;ITGB3 gene;Knowledge;Lesion;Link;Lipids;Machine Learning;Macrophage;Maps;Mediating;Metabolic;Metabolic Pathway;metabolomics;MicroRNAs;Modeling;Molecular;molecular modeling;monocyte;multidisciplinary;Nanotechnology;network models;novel;particle;Pathogenesis;Pathway Analysis;Pathway interactions;Patients;Peripheral Blood Mononuclear Cell;Persons;Phenotype;Plasma;Platelet Activation;Population;predictive modeling;premature;prevent;Process;Proteins;Proteomics;Research Infrastructure;Residual state;response;Risk;Role;screening;Signal Transduction;Small RNA;Source;Statistical Data Interpretation;Statistical Models;Stimulus;Techniques;Testing;tool;transcriptome;transcriptome sequencing;Translational Research;Validation;Viral Proteins;Virus Replication

PROJECT_TITLE: Role of platelet- monocyte interaction in promoting pro-atherogenic state in HIV-infected individuals

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Cystic Fibrosis;Infectious Diseases;Lung;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: PROJECT NARRATIVE Cystic Fibrosis (CF) is a genetic disease that affects more than 70,000 people worldwide and is characterized by the build up of thick mucus in patients’ lungs that traps bacteria (including Pseudomonas aeruginosa, Pa), leads to chronic infection, and progresses to death due to respiratory failure. This proposal will help close gaps in knowledge about which components of the CF-specific Pa LPS structure promote an inflammatory response, and how LPS structure alters the cellular immune response, with an aim toward developing new therapeutic targets.

PI_NAMEs: ERNST, ROBERT K;SCOTT, ALISON J (contact)

PROGRAM_OFFICER_NAME: UPADHYAY, MEENU MISHRA

PROJECT_TERMS: Acute;Acylation;Acyltransferase;Address;Affect;Airway Disease;airway inflammation;autosome;Bacteria;Bacterial Infections;Binding;Biological Models;Biology;bronchial epithelium;Carbon;Cell Death;Cell Line;Cells;Cessation of life;children with cystic fibrosis;Chronic;chronic infection;Clinical;Collection;Cystic Fibrosis;cystic fibrosis airway;cystic fibrosis infection;cystic fibrosis mouse;cystic fibrosis mucus;cystic fibrosis patients;cytokine;Data;design;Development;Dimensions;Disease;Disease Outcome;Disease Progression;emerging adult;Endotoxemia;Endotoxins;Engineering;Environment;Enzymes;experience;Family;Future;Genetic Diseases;Goals;Gram-Negative Bacteria;Hybrids;Hydroxylation;imaging study;Immune;Immune response;Impairment;In Situ;in vivo;Inbred BALB C Mice;Individual;Infection;Infection prevention;Infiltration;Inflammation;Inflammatory;inflammatory marker;Inflammatory Response;innate immune mechanisms;Innate Immune System;Iron;Knowledge;Length;Lipid A;Lipids;Lipopolysaccharides;Lung;Lung Diseases;Lung infections;Lysophospholipids;Macrophage;Maps;mass spectrometer;mass spectrometric imaging;Measures;Mediating;Membrane;Metabolic;Methods;microbial;molecular marker;mortality;mouse model;Mucous body substance;multimodality;Mus;neutrophil;Neutrophil Infiltration;new therapeutic target;novel;novel therapeutics;Outcome;Oxidants;pathogen;Pathogenesis;Pathogenicity;Patients;Persons;Phospholipids;premature;Pseudomonas;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;pulmonary function;Pulmonary Inflammation;Pulmonary Pathology;Receptor Cell;Regulation;Reporting;Respiratory Failure;Respiratory Tract Infections;response;Role;Septic Shock;Signal Transduction;Specificity;Structure;Structure of parenchyma of lung;targeted treatment;Technology;Testing;therapeutic target;Thick;Time;Tissues;United States;Variant;Virulence

PROJECT_TITLE: Microbial adaptation of Pseudomonas lipid A structure in CF airway disease progress

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: NARRATIVE Without the sense of touch, we could not survive; we could not interact with the environment or use objects. Moreover, the sense of touch has tremendous importance for the caring of our offspring and social bonding and is disrupted in many types of injuries and disease states. Despite the enormous importance of touch for human physiology, it remains the least understood of the senses. Touch is mediated by receptors in our skin composed of nerve cells and glia. The function of glia in touch receptors is largely unknown. In this proposal, I will use the pioneering model C. elegans to advance our understanding of the function of glia and of the cross talk between glia and nerve cells in touch. My work will help elucidate how glia of touch receptors and other sensory organs contribute to sensory perception.

PI_NAMEs: BIANCHI, LAURA  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: Adenylate Cyclase;Antigen-Presenting Cells;Area;Basic Science;Behavior;Behavioral Assay;Brain;Caenorhabditis elegans;Calcium;Caring;cell type;Cells;Communication;Complex;Cyclic AMP;Data;Dedications;Disease;Endowment;Environment;Epithelial Cells;epithelial Na+ channel;excitatory neuron;Exclusion;experimental study;Feedback;Functional Imaging;Funding;gamma-Aminobutyric Acid;Genes;Genetic;glial activation;Goals;Harvest;Human;Image;Imaging Device;in vivo;Injury;Ion Channel;knock-down;Knock-out;Mammals;mechanical force;Mediating;Meissners Corpuscle;Merkel Cells;model organism;Modeling;Molecular;mutant;Nerve;Nerve Endings;Nervous System;Neuroglia;Neuromodulator;neuronal excitability;Neurons;Neuropeptides;neurotransmission;Neurotransmitters;Nose;novel;offspring;optogenetics;Organ;Organism;Output;Perception;Physiology;Play;Process;Publishing;receptor;Regulation;repaired;response;Role;Sensory;sensory system;Serotonin;serotonin receptor;Signal Transduction;Skin;social attachment;System;Testing;tool;Touch sensation;transcriptome sequencing;Transducers;Trauma;Vertebrates;Work

PROJECT_TITLE: Glial ion channels in glia/neurons interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BN-G(06)]


ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: NARRATIVE Leukemias are cancers in which the bone marrow produces too many abnormal blood cells at the expense of normal blood cells. Here we will determine how a commonly occurring change in a gene called ZRSR2, which encodes a protein that participates in the process of RNA splicing, gives rise to leukemia. We will determine how ZRSR2 mutations drive leukemia and find new ways to treat leukemias with ZRSR2 mutations.

PI_NAMEs: ABDEL-WAHAB, OMAR  (contact);BRADLEY, ROBERT K

PROGRAM_OFFICER_NAME: KLAUZINSKA, MALGORZATA

PROJECT_TERMS: Adaptor Signaling Protein;Affect;AKT Signaling Pathway;Amino Acids;Biology;Blood Cells;Bone Marrow;Cells;Clonality;cohort;Collaborations;comparative;Complex;conditional knockout;Cytokine Signaling;Data;defined contribution;demethylation;Development;DNA;Dysmyelopoietic Syndromes;efficacy testing;Enzymes;Event;Exhibits;experimental study;functional genomics;Gene Expression;Genes;Genetic;Guanosine;Health;Hematopoiesis;Hematopoietic;hematopoietic stem cell self-renewal;Heterozygote;Human;inhibitor;Introns;Knockout Mice;leukemia;leukemogenesis;Link;loss of function;Malignant - descriptor;Malignant Neoplasms;Messenger RNA;Minor;Mitogen-Activated Protein Kinases;Modeling;Molecular;Mus;Mutagenesis;mutant;Mutate;Mutation;Myeloid Leukemia;Myeloproliferative disease;novel;novel therapeutic intervention;novel therapeutics;Open Reading Frames;Pathogenesis;Patient Care;Patients;Pattern;Physicians;PI3K/AKT;Process;Proteins;Proteome;PTEN gene;Publishing;Recurrence;response;RNA;RNA Degradation;RNA Splicing;Role;Scientist;self-renewal;Signal Pathway;Signaling Molecule;Spliceosomes;SRSF2 gene;Therapeutic;transcriptome;Translating;Tumor Suppressor Proteins;ubiquitin ligase;Ubiquitination;Work

PROJECT_TITLE: Interrogating the minor spliceosome to understand and treat leukemia

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Infectious Diseases;Microbiome;Patient Safety;Prevention;Wound Healing and Care

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative Surgical site infections (SSIs) represent a significant burden on the healthcare system, but we don’t know whether these bacterial pathogens originate from the skin or the gastrointestinal tract (gut). By identifying the site where pathogens originate and features of the microbiome associated with SSIs, we can develop targeted interventions to prevent SSIs.

PI_NAMEs: RICKARD, JENNIFER L (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Age;Antibiotics;Antisepsis;Bacteria;Case/Control Studies;Clinical Trials;cost;design;Development;Diagnosis;dysbiosis;Environment;gastrointestinal;Gastrointestinal Surgical Procedures;Gastrointestinal tract structure;Goals;Greater sac of peritoneum;gut microbiome;gut microbiota;Healthcare Systems;Hospitals;host microbiome;indexing;Infection;Infection prevention;innovation;Intervention;Intervention Studies;Knowledge;Length of Stay;Link;Measures;Metagenomics;microbial;microbial community;microbial host;microbiome;microbiota;mortality;Nosocomial Infections;operation;Operative Surgical Procedures;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Patients;Pattern;Perioperative;personalized approach;Postoperative Period;prevent;preventive intervention;Process;prospective;Rectum;Research;Resistance;RNA analysis;Sampling;sex;Shotguns;Site;Skin;skin microbiome;skin microbiota;Source;Surgical incisions;Surgical Wound Infection;Techniques;Testing;Time;transcriptome sequencing;Uncertainty;wound

PROJECT_TITLE: Surgical site infections and the microbiome: Understanding the pathogenesis of surgical site infections

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_CITY: SEATTLE

ORG_NAME: ALLEN INSTITUTE

ORG_STATE: WA

PHR: Project Narrative A detailed census of the structure and role of cell type specific data in the human and non-human primate brain is recognized as one of the most promising avenues for advancing our understanding of the human brain in health and disease. The BICAN program and its consortium will generate these data and atlases through a large collaborative network of investigators and laboratories. Operating through a strong consortium outreach and engagement unit, the effective consortium organization and management, delivery of data and process standards, and transparent reporting and governance will ensure the realized value and impact of these data and resources in facilitating ongoing and future progress in the field.

PI_NAMEs: HAWRYLYCZ, MICHAEL  (contact);THOMPSON, CAROL LYNN

PROGRAM_OFFICER_NAME: YAO, YONG

PROJECT_TERMS: Accountability;Agreement;Archives;Atlases;Brain;BRAIN initiative;Catalogs;cell type;Cells;Censuses;Collaborations;Communication;Communities;dashboard;Data;Data Collection;data curation;data dashboard;data ingestion;data sharing;Data Storage and Retrieval;data submission;Decision Making;Development;Disease;Documentation;Education and Outreach;Educational Activities;Ensure;Equipment and supply inventories;experience;FAIR principles;Future;Generations;Goals;Health;Human;improved;Information Networks;Infrastructure;interoperability;Laboratories;Maintenance;meetings;member;Metadata;metadata standards;Molecular;Monitor;Mus;nonhuman primate;Ontology;ontology development;operation;outreach;Persons;Process;Production;programs;Publications;Publishing;Reporting;Research;Research Personnel;Resources;Role;Route;Site;statistics;Structure;symposium;Taxonomy;tool;Training Activity;virtual;Work;working group

PROJECT_TITLE: A Community Resource for Single Cell Data in the Brain


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Acute myeloid leukemia (AML) has thus far proven resistant to recent advances in cancer immunotherapy, such as bispecific antibodies and chimeric antigen receptor (CAR) T cells. This proposal will investigate how targeting normal myeloid cells can have detrimental effects on CAR T cell activity. These results will help determine why CAR T cells have not been effective against AML, and identify methods to overcome these limitations and improve the success of this therapy.

PI_NAMEs: KIM, MIRIAM Y (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Affect;Allogenic;Antigen Targeting;antigen-specific T cells;antitumor effect;Attention;B-Lymphocytes;Bioinformatics;Biology;Biometry;Bispecific Antibodies;C57BL/6 Mouse;cancer immunotherapy;CAR T cell therapy;career;career development;CD19 gene;cell behavior;Cell Count;Cell Physiology;Cell Therapy;Cells;cellular engineering;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Complex;CRISPR/Cas technology;Data;Dendritic Cells;Development Plans;Disease;Disease Outcome;disorder control;Effector Cell;Engineering;Environment;Environmental Risk Factor;Exposure to;Flow Cytometry;Foundations;Future;Gene Modified;Gene Transfer;Goals;Harvest;Hematologic Neoplasms;Hematopoietic Stem Cell Transplantation;Hematopoietic stem cells;Hematopoietic System;Human;Immune;Immune system;Immunocompetent;Immunology;Immunotherapy;Impairment;improved;improved outcome;In Vitro;in vivo;Individual;Infection;innovation;Investigation;knockout gene;Learning;leukemia;Leukemic Cell;Macrophage;Mediator;Mentors;Methods;Modems;mouse model;Mus;Myelogenous;Myeloid Cells;Myeloproliferative disease;Nature;novel;Patients;Phenotype;Population;Research;research and development;Research Personnel;Resistance;response;single-cell RNA sequencing;skills;stem cell genes;success;T-Lymphocyte;targeted treatment;TCR Activation;therapy outcome;Time;Tissues;Toxic effect;Training;tumor;Universities;Viral Genes;Washington;Work

PROJECT_TITLE: Improving the activity of CAR T cells for acute myeloid leukemia

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Autism;Brain Disorders;Congenital Structural Anomalies;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: ANN ARBOR

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE CHARGE syndrome is a developmental disorder characterized by substantial behavioral and cognitive problems, including executive dysfunction and Autism Spectrum Disorder (ASD) also prevalent in many other neurodevelopmental disorders. In this study, we seek to understand how mutation of the gene that causes CHARGE syndrome disrupts critical processes in development of the neocortex, including patterning, brain growth and synaptogenesis. In the longer term, this work will help us understand the causes of specific brain disorders and the critical cell types and processes to target for therapeutic benefit.

PI_NAMEs: ANDREAE, LAURA ;BASSON, MICHIEL ALBERTUS;KWAN, KENNETH YU-CHUNG;MARTIN, DONNA M. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, ROBERT D

PROJECT_TERMS: Acute;Affect;Animal Model;Anterior;area striata;ATAC-seq;autism spectrum disorder;Behavioral;Brain;Brain Diseases;Cell Differentiation process;Cell Physiology;cell type;Cells;Cellular biology;CHARGE syndrome;CHD7 gene;ChIP-seq;Chromatin;chromatin remodeling;Chromatin Structure;Cognitive;Confocal Microscopy;Data;Development;developmental disease;Developmental Process;digital;Disease;Electrophysiology (science);Embryo;Enhancers;excitatory neuron;Excitatory Synapse;Executive Dysfunction;Exhibits;experimental study;Functional disorder;Gene Deletion;Gene Expression;Gene Mutation;Genes;Genetic;Genetic Transcription;Genomics;Growth;Heterozygote;Human;In Situ Hybridization;individuals with autism spectrum disorder;inhibitory neuron;Inhibitory Synapse;innovation;Knowledge;Link;Methods;Molecular;multiple omics;Mus;Mutate;Mutation;Neocortex;neocortical;nerve stem cell;Neurodevelopmental Disorder;neurogenesis;Neurons;neuropsychiatric disorder;overexpression;patch clamp;Pathogenicity;Pattern;Phenotype;Physiologic pulse;Physiology;Population;postnatal;Prefrontal Cortex;Process;progenitor;Proliferating;Proteins;Regulatory Element;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Role;sex;single cell ATAC-seq;single cell sequencing;Slice;stem cell differentiation;stem cell proliferation;Study models;Synapses;synaptogenesis;Syndrome;targeted treatment;Testing;Time;tool;translational model;Variant;Visual;Visual Cortex;Visualization;Wild Type Mouse;Work

PROJECT_TITLE: Dissecting Cell Type Specific Functions of CHD7 in Development of the Neocortex

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: DA

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Chronic Pain;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Physical Injury - Accidents and Adverse Effects;Racial and Ethnic Minority Health Research;Substance Misuse

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative  By clarifying the extent to which long-term opioid therapy tapering is associated with increased risk of overdose, opioid and other substance use disorder, and intentional self-harm, the proposed research will be directly relevant to the goal of improving the safety of opioid prescribing practices. Specifically, the proposed project would help improve the specificity and confidence of guidelines and policies for safer tapering practices (e.g., the 2022 CDC Clinical Practice Guideline for Prescribing Opioids for Pain), including by identifying clinical and social subgroups that may face greater risk following tapering, which would enhance strategies to balance control of pain with patient safety and equity.

PI_NAMEs: QUINN, PATRICK DONOVAN (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Academy;Adult;Adverse effects;Affect;Black race;chronic pain;chronic pain management;Clinical;Clinical Practice Guideline;Complement;Consensus;COVID-19 pandemic;Data;Decision Aid;Decision Making;design;dosage;Dose;Equilibrium;Equity;Ethnic Population;evidence base;evidence based guidelines;experience;Goals;Guidelines;Healthcare;Heterogeneity;Hispanic;improved;Individual;individual patient;individual variation;innovation;insurance claims;International;Intervention;Journals;Latino;Literature;Long-Term Effects;marginalization;Measurement;Measures;Medical;Medicare;Medicine;Mental Health;Methods;non-opioid analgesic;Opioid;Opioid Analgesics;opioid tapering;opioid therapy;opioid use disorder;Outcome;Overdose;overdose risk;Pain;Pain management;pain relief;Paper;Patient Care;Patient risk;patient safety;Patients;Persons;Pharmacoepidemiology;Policies;population health;prescription opioid;programs;Published Comment;racial population;Recommendation;Reproducibility;Research;Research Design;Risk;Risk Estimate;Safety;Self-Injurious Behavior;social;Specificity;Subgroup;Substance Use Disorder;Time;United States Department of Veterans Affairs

PROJECT_TITLE: Assessing real-world evidence of the effects of opioid analgesic tapering on substance-related problems


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

PHR: Narrative We will develop an ultrafast and very-high-resolution system for volumetric pediatric imaging. The system will facilitate imaging of children who are too young to be imaged with MRI or CT without anesthesia and will provide resolution on the order of hundreds of microns.

PI_NAMEs: FERRARA, KATHERINE W (contact);VASANAWALA, SHREYAS S;ZHOU, QIFA

PROGRAM_OFFICER_NAME: KING, RANDY LEE

PROJECT_TERMS: 3-Dimensional;Abdomen;Abdominal Pain;Acceleration;Acoustics;Address;Adult;Anatomy;Anesthesia procedures;angiogenesis;assessment application;Biological Assay;Blood flow;Blood Flow Velocity;Blood Vessels;bone;Buffers;California;Cancerous;Cardiology;Child;Childhood;Color;Computer software;contrast imaging;cost;Cyst;Data;data visualization;Dedications;Dependence;design;Detection;Development;Diagnosis;Electronics;Elements;fetal;flexibility;follow-up;Goals;Heart Valves;Image;imaging capabilities;Imaging Device;imaging study;imaging system;improved;integrated circuit;Intervention;Ionizing radiation;Kidney;kidney imaging;Lesion;Liquid substance;Liver;liver imaging;Location;Magnetic Resonance Imaging;Maps;Measurement;meter;Motion;Myocardium;operation;Organ Size;Patients;Pediatric cohort;pediatric patients;Pediatrics;Penetration;Phase;Physiology;Population;Protocols documentation;Radiation;radiologist;Radiology Specialty;real-time images;reconstruction;Resolution;Scanning;Signal Transduction;Slice;software development;Speed;Structural defect;Structure;System;Technology;Testing;Thick;three-dimensional visualization;Time;Tissues;tool;Transducers;Trauma;two-dimensional;Ultrasonography;ultrasound;Universities;Vision;Visualization;volunteer

PROJECT_TITLE: Pediatric volumetric ultrasound scanner

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Cystic Fibrosis;Emerging Infectious Diseases;Infectious Diseases;Lung;Orphan Drug;Rare Diseases;Wound Healing and Care

ORG_CITY: NORMAL

ORG_DEPT: BIOLOGY

ORG_NAME: ILLINOIS STATE UNIVERSITY

ORG_STATE: IL

PHR: NARRATIVE New antimicrobial strategies are desperately needed as the spread of antimicrobial resistance is rapidly compromising the effectiveness of current antibiotics. The overall goal of this application is to discover and characterize novel bacterial response and defense mechanisms during RO/CS-stress. We will define how the novel silver-containing antimicrobial AGXX potentiates the bactericidal effects of aminoglycosides on P. aeruginosa and identify strategies by which this intrinsically antibiotic-resistant pathogen responds to and defends AGXX.

PI_NAMEs: DAHL, JAN-ULRIK  (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Acute;Adjuvant;Affect;alternative treatment;Aminoglycoside Antibiotics;Aminoglycosides;Antibiotic Resistance;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacterial Infections;bactericide;burn therapy;burn wound;Cell Line;Cells;cellular targeting;Clinical;clinically relevant;Combined Modality Therapy;cystic fibrosis patients;cytotoxicity;Data;Defense Mechanisms;Development;drug development;Drug resistance;drug resistant pathogen;Effectiveness;electric field;experimental study;Formulation;Goals;Gram-Negative Bacteria;Gram-Positive Bacteria;Growth;Homeostasis;Hydrogen Peroxide;Hydroxyl Radical;Infection;insight;interest;Iron;Lead;Life Style;Mediating;Medical Device;Membrane;Microbial Biofilms;Molecular;mutant;novel;novel therapeutics;Oxidation-Reduction;pathogen;Patients;Phenotype;Polyphosphates;Predisposition;prevent;Prevention strategy;Production;Property;Proteins;proteotoxicity;Pseudomonas aeruginosa;Pseudomonas aeruginosa infection;Pulmonary Cystic Fibrosis;Reaction;Reactive Oxygen Species;Reporting;Resistance;response;Ruthenium;Sepsis;Silver;Silver Compounds;Stress;Sulfadiazine;Sulfur;Superoxides;surface coating;synergism;System;Testing;Tissues;Transition Elements;transposon sequencing;treatment strategy;uptake;Urinary tract infection;Wound Infection

PROJECT_TITLE: Elucidating bacterial responses to the novel antimicrobial AGXX

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Childhood Obesity;Clinical Research;Digestive Diseases;Genetics;Microbiome;Nutrition;Obesity;Pediatric;Prevention

PHR: PROJECT NARRATIVE  The proposed research is relevant to public health because it will define mechanistically how a risk factor for obesity regulates host metabolism through the microbiota. The research will also enhance our understanding of Intelectin-1 on metabolic syndrome and the translational implications of Intelectin-1 interaction with the microbi- ota in early life weight gain and childhood obesity. The proposed studies are relevant to the mission of the NIDDK as our studies are expected to identify new insights into factors associated with metabolic syndrome and eluci- date potential mechanisms and, thus, therapeutic strategies for preventing obesity starting in infancy.

PI_NAMEs: MATUTE, JUAN D. (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Acetates;Acetylation;Adult;Affect;American;Antibiotics;Atropine;Award;Bacteria;Binding;Bioinformatics;Biological;biomarker identification;Birth;career;career development;Childhood;cohort;Communities;Complement;critical period;design;Development;Development Plans;Diet;diet-induced obesity;early childhood;Eating;Ecology;Enteral;Epithelial Cells;excessive weight gain;Exposure to;Feces;Funding;Genetic;Genetic Polymorphism;genetic risk factor;Genetic Transcription;germ free condition;Germ-Free;ghrelin;Gnotobiotic;Goals;Grant;growth hormone releasing hexapeptide;gut microbes;gut microbiota;High Fat Diet;host microbiome;host microbiota;host-microbe interactions;Human;Immunology;In Vitro;in vivo;infancy;Infant;Inflammatory Bowel Diseases;insight;Institution;Insulin Resistance;interdisciplinary approach;intestinal epithelium;Intestines;Journals;K-Series Research Career Programs;Life;Measures;medical schools;Medicine;Mentors;Mentorship;Metabolic;Metabolic syndrome;Metabolism;Metagenomics;metatranscriptomics;Methods;Microbe;microbial;Microbiology;microbiome;microbiota;Mission;Modeling;mouse model;Mucous Membrane;Mus;National Institute of Diabetes and Digestive and Kidney Diseases;neonatal period;novel;Obesity;obesity development;obesity in children;obesity prevention;obesity risk;Oral Administration;Organism;Outcome;overexpression;pandemic disease;Parasympathetic Nervous System;pharmacologic;Phenotype;Physicians;Pre-Clinical Model;Predisposition;prevent;Production;Protein Secretion;Proteins;Public Health;rapid weight gain;Regulation;Research;Research Personnel;Research Project Grants;Research Proposals;response;Risk Factors;Role;Scientist;Secure;skills;sleep health;Starch;Supplementation;Testing;Therapeutic;Training;transcriptomics;Translational Research;translational study;Weaning;Weight;Weight Gain;Wild Type Mouse;Work

PROJECT_TITLE: Intestinal Intelectin-1 regulation of obesity development

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Prostate Cancer;Rare Diseases;Urologic Diseases

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: PROJECT NARRATIVE Previously, we have shown that immune “cold” cancers such as prostate and pancreatic cancer that do not respond to immunotherapy have extensive regions which lack oxygen (hypoxia), and that these regions lack T and NK cells necessary to mediate tumor regression. Using a unique panel of compounds, we and others have found to modulate tumor hypoxia, we will both reveal the relative contribution of reduced oxygen supply versus enhanced tumor oxygen metabolism in causing hypoxia, as well as determine the optimal approach to reduce tumor hypoxia in an immune-potentiating context. Critical to understanding the mechanisms underlying these observations, we will map the hypoxia-triggered signals regulating acquisition of suppressive function and driving metabolic adaptation of tumor-supportive stroma to the hypoxic state.

PI_NAMEs: CURRAN, MICHAEL A. (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Activities of Daily Living;Angiogenesis Inhibitors;Animals;Automobile Driving;Blood;cancer infiltrating T cells;Cancer Model;Cell Density;Cell Hypoxia;Cells;Cellular Metabolic Process;chemotherapy;Clinical;Clinical Trials;Complex;Consumption;Coupled;CTLA4 gene;Elements;Equilibrium;Failure;Fibroblasts;fitness;Fostering;Glycolysis;Hypoxia;hypoxia inducible factor 1;Image;Immune;immune cell infiltrate;immune checkpoint blockade;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;inhibitor;insight;Intervention;Kinetics;Knock-out;Knowledge;Maintenance;Malignant neoplasm of pancreas;Malignant neoplasm of prostate;Malignant Neoplasms;Maps;Measures;Mediating;Memory;Metabolic;Metabolism;Metformin;Molecular;mouse model;Mus;Myelogenous;Myeloid Cells;Myofibroblast;Natural Killer Cells;normoxia;Outcome;Oxidative Phosphorylation;Oxygen;Oxygen Consumption;pancreatic cancer model;pancreatic neoplasm;Patients;Phenotype;Process;Prodrugs;programs;prostate cancer model;Prostatic Neoplasms;Radiation therapy;refractory cancer;Resistance;response;restoration;Retreatment;Role;Signal Transduction;Source;subcutaneous;T cell infiltration;T-Lymphocyte;Therapeutic;Time;Tissues;transcription factor;tumor;tumor hypoxia;Tumor Immunity;tumor metabolism;tumor progression;Work

PROJECT_TITLE: Breaking down tumor immune privilege through targeted hypoxia reduction

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Narrative Mammalian enteric viruses are important and common human infections, but factors that control their replication in the intestine are unclear. This work will examine how intestinal microbiota influence infection with reoviruses through distinct pathways depending on properties of the viral strain.

PI_NAMEs: PFEIFFER, JULIE K (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Amino Acids;Anatomy;Anti-viral Response;Bacteria;Binding;Biology;Cells;Collection;Complex;Coxsackie Viruses;Data;Enteral;enteric virus infection;Environment;Epithelial Cells;Event;experimental study;Family;Genetic Polymorphism;Glycobiology;gut microbiota;Home;Human;Human poliovirus;Immune response;In Vitro;in vivo;Infection;innate immune pathways;Innate Immune Response;insight;Interferon Type II;Interferons;intestinal epithelium;Intestines;Lamina Propria;Leucine;Ligands;M cell;Mediating;member;Microbe;microbial;microbial community;microbiota;Modeling;Mus;Norovirus;Pathway interactions;Polysaccharides;Predisposition;Proline;Property;Proteins;Publishing;Reoviridae;Reovirus;Reovirus Infections;Research;response;Rotavirus Infections;Science;Sialic Acids;Specificity;System;Testing;Tropism;Viral;Virion;virology;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: Enteric virus-microbiota interactions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences

ORG_CITY: DAVIS

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: Project narrative Normal physiology and behavior as well as human diseases exhibit seasonal cycles; however, the mechanisms that organisms use to track calendar time thus generating these variations are not fully understood. This project will investigate the mechanisms by which seasonal cues impact the structure and function of neuronal circuits involved in daily timekeeping and in aminergic circuits, both suggested to be important for seasonal biology. This project will yield new insights into seasonal neuronal plasticity, which can be exploited to develop therapeutic approaches for illnesses such as seasonal affective disorder and depression.

PI_NAMEs: HIDALGO SOTELO, SERGIO IGNACIO (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affect;Animal Model;Animals;Area;Autopsy;Award;Behavior;Behavioral;Binding;Biochemistry;Biogenic Amines;Biology;Brain;Calendar;career;Cells;circadian;circadian pacemaker;Cues;day length;density;Disease;Dopamine;dopaminergic neuron;Drosophila genus;dynamic system;Etiology;Exhibits;Exposure to;Fluorescent in Situ Hybridization;fly;Foundations;functional plasticity;Generations;Goals;Health;Hour;Human;human disease;Hypothalamic structure;Immunohistochemistry;in vivo;insight;Knowledge;Light;light intensity;Link;Mammals;Mediating;Membrane;Mental Depression;Mentors;Mentorship;Methods;Microscopy;Modeling;Molecular Genetics;Motor Activity;Nature;neurogenetics;neuronal circuitry;Neuronal Plasticity;Neurons;Neuropeptides;Neurotransmitters;Organism;Outcome;Output;paraventricular nucleus;Peptides;Periplasmic Binding Proteins;Photoperiod;photoperiodicity;Physiology;Positioning Attribute;Postdoctoral Fellow;Prevalence;Process;Proteins;Reporting;Research;Research Personnel;Resolution;response;Role;Seasonal Affective Disorder;Seasonal Variations;Seasons;sensor;sensory integration;Serotonin;Signal Transduction;social;Structure;success;suprachiasmatic nucleus;Synapses;System;Temperature;Testing;Therapeutic;Time;tool;Training;transcriptomics;Variant

PROJECT_TITLE: Integration of seasonal cues to modulate neuronal plasticity

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: EY

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Diabetes;Eye Disease and Disorders of Vision;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Information in medical imaging is difficult to quantify, and thus hinder its secondary use a phenotype. We will develop a novel artificial intelligence-based strategy to extract phenotype information from human retina images, and identify genes associated with these eye phenotypes and diseases. Successful completion of the project will not only gain new knowledge about eye diseases, but also establish a neural network architecture that can be adopted to downstream clinical uses such as automatic grading tools.

PI_NAMEs: CHEN, RUI ;ZHI, DEGUI  (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: 3-Dimensional;Adopted;Age;Algorithms;Artificial Intelligence;biobank;bioinformatics tool;Candidate Disease Gene;cardiovascular risk factor;Chromosome Mapping;Classification;Clinical;Clinical Data;clinical imaging;Clinical Research;Communities;Computer software;Data;data resource;deep learning;deep learning algorithm;deep learning model;Descriptor;Development;Diabetes Mellitus;Diabetic Retinopathy;Diagnostic;Disease;disorder risk;efficacy testing;endophenotype;Exclusion;Eye;Eye diseases;Funding;Fundus;fundus imaging;Gender;Genes;Genetic;Genetic study;genome wide association study;genomic locus;Goals;Health Status;Heritability;high dimensionality;Human;Image;Individual;insight;Knowledge;Label;Learning;Liquid substance;macular edema;Manuals;Maps;Masks;Medical;Medical Imaging;Methods;Microaneurysm;Modality;Modeling;Morphology;multimodality;natural language;neovascularization;neural network architecture;novel;novel strategies;Optical Coherence Tomography;Output;Participant;Pathologic;Patient imaging;Patients;Pattern;Persons;Phenotype;Physiology;Process;Reading;reconstruction;Reporting;Research;response;Retina;Retinal Diseases;Retinal Hemorrhage;retinal imaging;Scanning;Self Perception;self supervised learning;Standardization;Stimulus;success;supervised learning;Supervision;targeted treatment;Testing;Thick;tool;Training;Validation;Visual System;Visualization

PROJECT_TITLE: Deep-Learning-Derived Endophenotypes  from Retina Images


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vaccine Related

ORG_CITY: IOWA CITY

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Dime la VerDAD (Verify, Debunk And Disseminate) will evaluate the use of storytelling by promotores de salud as a communication strategy to identify and debunk misinformation on social media and improve vaccine uptake for COVID-19 and influenza in largely Hispanic communities in the city of Chicago. This work will test a model of community engagement and empowerment around health communication while providing greater understanding as to how credible scientific information can be shared so that it changes opinions and behaviors. Our approach uses a rigorous stepped-wedge design to address an under-explored and vital issue of misinformation spread within communities that experience health disparities.

PI_NAMEs: DEL RIOS, MARINA  (contact)

PROGRAM_OFFICER_NAME: JONES, NANCY LYNNE

PROJECT_TERMS: Acceleration;Address;Adult;Affect;Amplifiers;Attitude;Behavior;Chicago;Cities;combat;Communication;Communities;community empowerment;community engagement;Community Health Aides;COVID-19;COVID-19 disparity;COVID-19 misinformation;COVID-19 pandemic;COVID-19 vaccination;COVID-19 vaccine;design;Diffuse;digital;disinformation;Educational Curriculum;Effectiveness;effectiveness testing;empowerment;Ethnic Population;Evaluation;experience;Face;Focus Groups;Health;health care availability;health communication;health disparity;Health Professional;Health Services Accessibility;Hispanic;hispanic community;Hispanic Populations;Household;Illinois;Immunization;Improve Access;improved;Influenza;Influenza vaccination;influenza virus vaccine;Infodemiology;informant;innovation;Interpersonal Relations;Interview;Knowledge;Language;Learning;Link;Measures;Medical;member;Misinformation;Modeling;multidisciplinary;Occupational Exposure;Outcome;pandemic disease;Participant;peer;Perception;personal narratives;Persons;Positioning Attribute;prevent;preventable death;Process;programs;racial minority population;Recommendation;recruit;SARS-CoV-2 infection;Science;service delivery;skills;social;social media;Social Network;Social Work;Source;Spanish;Spanish/English;Standardization;Subgroup;Surveys;Testing;testing uptake;tool;Training;Training Programs;Translating;Trust;uptake;Vaccinated;Vaccination;vaccine acceptance;vaccine access;vaccine development;vaccine hesitancy;vaccine safety;Vaccines;Work

PROJECT_TITLE: Dime la VerDAD (Verify, Debunk, and Disseminate)


ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative Symptom checker apps have the potential to improve early recognition of important diseases, improving patients’ own diagnoses and decisions to seek care, but lack evidence of safety and performance. This proposal will rigorously evaluate clinical use, diagnostic and triage accuracy, and effect on patients’ care seeking decisions of a leading symptom checker in emergency and urgent primary care settings, including stroke patients. It will also utilize three unique data sets on TIA and stroke patients to evaluate effects of patient characteristics on stroke diagnosis by symptom checkers, and create new diagnostic and triage algorithms.

PI_NAMEs: FRASER, HAMISH SF (contact)

PROGRAM_OFFICER_NAME: TERAN, MARIO

PROJECT_TITLE: Evaluating diagnostic decision support systems for patients requiring urgent primary or emergency care or with stroke


ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: Project Narrative:  Of the approximately half-million adult patients who undergo cardiac surgery every year in the United States, 25% suffer acute kidney injury (AKI) after surgery. This project will primarily characterize the association between early postoperative blood pressure and AKI, while also exploring for evidence of association between early postoperative blood pressure and other non-renal patient harm. Innovative use of minute-by-minute blood pressure data through 24 hours after cardiac surgery will precisely identify blood pressure thresholds and durations beyond which the risk of AKI and other patient harm increases, providing critical information to justify and inform the design of a randomized trial of an alternate postoperative target blood pressure to reduce AKI and improve patient outcome after cardiac surgery.

PI_NAMEs: MCILROY, DAVID RICHARD (contact)

PROGRAM_OFFICER_NAME: GRIPIOTIS, EROFILE

PROJECT_TITLE: Evaluating the association between mean arterial blood pressure through the first 24 hours after cardiac surgery and postoperative acute kidney injury

STUDY_SECTION: HSQR

STUDY_SECTION_NAME: Healthcare Patient Safety and Quality Improvement Research[HSQR]


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE To address the FDA’s need for expanded regulatory science capabilities, the Research Triangle Center of Excellence in Regulatory Science and Innovation (Triangle CERSI) will provide a generative community for regulators, academia, and industry while serving as a one-stop-shop accelerator to meet current and evolving needs of regulatory science. The Triangle CERSI represents a collaboration of four leading academic institutions in North Carolina that are in close proximity (the University of North Carolina at Chapel Hill, Duke University, North Carolina State University, and North Carolina Central University). The Triangle CERSI aims to fully deploy our broad, collective expertise and close collaborations with FDA personnel to create and expedite utilization of important new knowledge in regulatory science and to provide an infrastructure of flexible and innovative toolsets to enrich the efficiency and value of FDA activities as part of the national CERSI program.

PI_NAMEs: HALABI, SUSAN ;MENTZ, ROBERT JOHN;SAMEI, EHSAN ;WATKINS, PAUL B (contact)

PROGRAM_OFFICER_NAME: CHEN, TRACY


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Data Science;Mental Health;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: WOODS HOLE

ORG_NAME: MARINE BIOLOGICAL LABORATORY

PHR: PROJECT NARRATIVE Advanced computational approaches are required to understand the complexity of the nervous system and to treat neural diseases. The Methods in Computational Neuroscience Course (MCN) provides a unique training environment that gives trainees a set of cutting-edge computational tools to analyze the explosion of neural data emerging from advanced experimental techniques, and to build powerful computer models of brain circuits. These concepts, tools and techniques will train a new generation of experimentalists and theorists to understand brain function and to treat brain disorders, including schizophrenia, epilepsy, addiction, depression, and Parkinson’s disease, as well as a new component explicitly dedicated to computational psychiatry, a nascent field bridging computational neuroscience and mental health. !

PI_NAMEs: HYMAN, LINDA E (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: addiction;Address;Anatomy;Behavior;Behavioral;Biological;Biological Process;Biological Sciences;Brain;brain cell;Brain Diseases;career;cell type;Collaborations;computational neuroscience;Computational Technique;Computer Models;computerized tools;Computers;Computing Methodologies;Data;Data Set;Dedications;density;design;Diagnosis;dimension reduction;Disease;diverse data;Environment;Epilepsy;Event;experimental study;Explosion;Faculty;faculty mentor;Fostering;Foundations;Generations;Goals;Human;Image;Individual;innovation;Instruction;interdisciplinary collaboration;International;Laboratories;laboratory curriculum;large datasets;Learning;lectures;marine;mathematical sciences;Mathematics;Measurement;Mental Depression;Mental disorders;Mental Health;Mentors;Mentorship;Methods;Modeling;Nervous System;neural;neural circuit;Neurobiology;neuromechanism;Neurons;neurophysiology;novel;Optics;optogenetics;Parkinson Disease;Participant;Pathology;Population;Problem Sets;Psychiatry;Request for Proposals;Research Project Grants;Schizophrenia;Scientist;Series;skills;Statistical Data Interpretation;student training;Students;System;Talents;teaching assistant;Techniques;theories;tool;Training;training opportunity;Update;Vocabulary;web site;Work

PROJECT_TITLE: Training in Methods of Computational Neuroscience (MCN)


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Genetics;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: Acute myeloid leukemia (AML) is the most common acute leukemia in adults with a devastating prognosis for elderly patients. We discovered an unexpected link between metabolism and gene expression in AML, and we will interrogate this mechanism in animal models and patient samples to examine whether we could therapeutically target this mechanism to treat AML. Our study may lead to a novel combinatorial therapy that could deeply suppress AML.

PI_NAMEs: NAKADA, DAISUKE  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: 1p36;5'-AMP-activated protein kinase;Ablation;Acetates;Acetyl Coenzyme A;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Age;Anabolism;Animal Model;Binding Proteins;Biological Assay;Bromodomain;Catabolism;Cell model;Cells;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Coenzyme A Ligases;combinatorial;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Data;Defect;dietary restriction;Enzymes;epigenetic drug;Epigenetic Process;epigenome;experimental study;Family member;FLT3 gene;Funding;Gene Deletion;Gene Expression;gene-editing approach;Genes;genetic approach;Genetic study;Genetic Transcription;glucose metabolism;Goals;Hematopoietic stem cells;Histone Acetylation;Homeostasis;Human;Impairment;improved;inhibitor;innovation;insight;leukemia;leukemia initiating cell;leukemia treatment;leukemogenesis;Link;Mediating;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;metabolomics;Methods;MLL-AF9;Modeling;mouse model;Mus;novel;novel therapeutics;older patient;patient derived xenograft model;Patients;pharmacologic;pre-clinical;Prognosis;Proliferating;protein kinase inhibitor;Proteins;recruit;Regulation;Sampling;stem cells;synergism;Testing;Therapeutic;therapeutic target;Xenograft Model;Xenograft procedure

PROJECT_TITLE: METABOLIC REGULATION IN LEUKEMIA-INITIATING CELLS

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


ORG_CITY: Columbus

ORG_DEPT: PATHOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECTIVE NARRATIVE  Microglia are a major and stable viral reservoir for persistent/latent HIV infection in the central nervous system (CNS), despite combinatorial anti-retroviral therapy (cART).  Epigenetic regulation critically determines the faith of HIV proviruses and contributes significantly to persistent/latent HIV infection in viral reservoirs cells, including microglia.  We will investigate how epigenetic regulation can control HIV proviruses and evaluate the therapeutic potential of repurposing FDA-approved drugs for treating HIV infection in brain.

PI_NAMEs: HO, WENZHE ;ZHU, JIAN  (contact)

PROGRAM_OFFICER_NAME: RAO, VASUDEV RAMACHANDRA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;Anatomy;antiretroviral therapy;Blood;Blood - brain barrier anatomy;Brain;brain tissue;Cells;Central Nervous System;Cessation of life;chromatin remodeling;Clinic;Clustered Regularly Interspaced Short Palindromic Repeats;combinatorial;CRISPR screen;demethylation;effective intervention;Epidemic;Epigenetic Process;epigenetic regulation;Faith;FDA approved;functional genomics;Gene Expression;Genes;Genetic Transcription;Histones;HIV;HIV Infections;HIV-associated neurocognitive disorder;Human;induced pluripotent stem cell;Integration Host Factors;interdisciplinary approach;Intervention;Knock-out;latent infection;Levosimendan;Libraries;Link;Lysine;Lytic;Mediating;Methylation;Microglia;migration;Molecular;monocyte;neuroinflammation;neurotoxic;novel;Nuclear Proteins;Organoids;Pharmaceutical Preparations;Preclinical Testing;prevent;Protein Dynamics;Proteomics;Proviruses;Reagent;Regimen;Regulation;Reporting;research clinical testing;Role;Site;Therapeutic;therapeutically effective;translational study;Viral;Viral reservoir;Virus;Withdrawal

PROJECT_TITLE: Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in Microglia


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Maintenance of genome integrity is a fundamental function of all cellular life that depends upon robust antioxidant systems to defend against reactive oxygen species. I discovered a novel nuclear function for ATP synthase subunit alpha (ATP5A1) to respond to oxidative stress that involves suppression of RNA/DNA hybrids and protection from DNA damage. This project will further elucidate the role of ATP5A1 in coordinating oxidative metabolism with genome maintenance and lead to new research and therapeutic opportunities at the interface of oxidative stress, genome maintenance, and cancer.

PI_NAMEs: PFISTER, NEIL THOMAS (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Adenocarcinoma Cell;Aging;Amino Acids;analytical method;Antibodies;antibody detection;Antioxidants;Binding;Biochemical;Biological;Biology;cancer initiation;cancer therapy;career;career development;Cell Fate Control;Cell Fractionation;cell killing;Cell Nucleus;Cell Respiration;Cells;Cessation of life;Co-Immunoprecipitations;Complex;Comprehensive Cancer Center;CRISPR/Cas technology;crosslink;Data;design;DNA;DNA Damage;DNA Double Strand Break;DNA lesion;DNA Repair;DNA replication fork;DNA-PKcs;Doctor of Philosophy;Electron Transport;Environment;Event;Funding;Gamma-H2AX;Genetic;Genome;genome integrity;genome-wide;Goals;hands on research;Hybrids;Immunoprecipitation;Impairment;innovation;Ionizing radiation;K-Series Research Career Programs;knock-down;Knock-out;Laboratories;Life;LIG4 gene;Link;Lung Adenocarcinoma;Maintenance;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Mediating;Mediator;Mentors;Mentorship;Mitochondria;Mitochondrial Proton-Translocating ATPases;Molecular;N-terminal;novel;Nuclear;Organism;overexpression;Oxidative Stress;Oxygen;p53-binding protein 1;Pathologic;Peptides;Phenocopy;Physicians;Poly Adenosine Diphosphate Ribose;Poly(ADP-ribose) Polymerases;pressure;prevent;Production;Protein Binding Domain;Proteins;Protons;Reactive Oxygen Species;recruit;Regulation;Repression;Research;Research Technics;Research Training;Resolution;response;RNA;RNA helicase A;Role;Scientist;Site;Stress;Structure;System;Testing;Therapeutic;Time;Training;Universities;Variant;Work

PROJECT_TITLE: Elucidating the Mitochondrial and Nuclear functions of ATP Synthase Subunit ATP5A1 that Maintain Genome Integrity in Response to Oxidative Stress


ORG_CITY: LEGON

ORG_COUNTRY: GHANA

ORG_FIPS: GH

ORG_NAME: NOGUCHI MEMORIAL INSTITUTE / MEDICAL RES

PHR: PROJECT NARRATIVE HIV infected person with persistently low-level viremia (pLLV) of 50-999copies per ml are not given much attention in resource-limited setting but lumped up with the virally suppressed. Since viral replication continues during low-level viremia, drug resistance could emerge in these individuals, derail the gains made with ART and increase the HIV latent reservoir size. This proposal therefore seeks to determine the impact of pLLV on HIV-1 subtypes, drug resistance and characteristics of the latent reservoir.

PI_NAMEs: BONNEY, EVELYN YAYRA (contact)

PROGRAM_OFFICER_NAME: SHANKAR, UDAY K

PROJECT_TERMS: Africa;antiretroviral therapy;Attention;Biological Assay;Breeding;Categories;CD4 Positive T Lymphocytes;Cells;Characteristics;clinically relevant;Clonal Expansion;Clonality;Code;cohort;Computer software;deep sequencing;Developed Countries;DNA;Drug resistance;Evaluation;Evolution;Feeds;Frequencies;Genetic;Genetic Variation;genome sequencing;Genotype;Ghana;HIV;HIV Genome;HIV-1;Individual;Infrastructure;Integrase;integration site;Knowledge;latent HIV reservoir;Length;Libraries;Life;Measures;Methods;Monitor;nanopore;Participant;Patients;Peptide Hydrolases;Persons;Phylogenetic Analysis;Plasma;Population;programs;Proliferating;Proviruses;Recombinants;Resistance;resistance mutation;Resource-limited setting;Rest;RNA;RNA-Directed DNA Polymerase;Sampling;Source;success;Technology;transcriptome sequencing;treatment guidelines;Ultracentrifugation;Viral;Viral Load result;viral rebound;Viral reservoir;Viremia;Virion;Virus;Virus Latency;Virus Replication;World Health Organization

PROJECT_TITLE: "Viral and latent HIV reservoir characteristics in HIV patients with persistent low-level viremia

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Prevention;Substance Misuse

ORG_NAME: WASHINGTON UNIVERSITY

PHR: Project Narrative This proposal is to continue a dynamic career development program to train clinician scientists conducting research on substance use disorder. The program will fund two scholar faculty positions at Washington University School of Medicine each year, develop career development plans specific to each scholar’s research interests, provide mentorship for scholars, continue robust procedures to evaluate the program, and establish a network of program directors and scholars across the nation to address common challenges in substance use disorder research and training. This program is important to ensure that there are well-trained clinician scientists in the prevention and treatment of substance use disorder in order to improve human health.

PI_NAMEs: BIERUT, LAURA J. (contact);CAVAZOS-REHG, PATRICIA A

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: Address;career;career development;Cause of Death;clinical care;Communication;Communities;Complex;design;Development;Development Plans;Discipline;Drug abuse;Drug Addiction;Educational Curriculum;Equilibrium;Evaluation;Faculty;Fostering;Funding;Genetic;Goals;Individual;interdisciplinary approach;interest;Interview;Life;medical schools;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Methodology;Monitor;National Institute of Drug Abuse;next generation;Positioning Attribute;Prevention;Program Development;programs;Research;Research Personnel;Research Project Grants;resilience;Resource Sharing;Science;Scientist;Substance Use Disorder;substance use treatment;Surveys;Technology;Training;training opportunity;Training Programs;Universities;Washington;Work

PROJECT_TITLE: Washington University Career Development Program in Drug Abuse and Addiction


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: Glucocorticoids regulate genetic programs in all tissues to control inflammation, metabolism, and differentiation as a primary stress response hormone, but synthetic glucocorticoids can achieve tissue- selective effects through unknown mechanisms. The goal of this project is to understand how differences in the chemical structure of the synthetic glucocorticoids alters the shape of the receptor to differentially control stress responses across tissues, and in doing so develop glucocorticoids for treatment of colitis with improved skeletomuscular on target side-effects

PI_NAMEs: NETTLES, KENDALL W (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: A549;Acute;Agonist;Allosteric Regulation;antagonist;Anti-Inflammatory Agents;Antiinflammatory Effect;BCL2L1 gene;Binding;Biological;biological adaptation to stress;Biological Assay;Biology;blood glucose regulation;bone;Cells;Chemical Structure;Chemicals;Chemistry;Chronic;Code;Colitis;Corticosterone;Data;design;Development;Disease;Dissociation;Docking;Enzymes;Equilibrium;experimental study;Fasting;feeding;functional genomics;G-Protein-Coupled Receptors;Gene Expression Regulation;Generations;Genes;Genetic;Genetic Transcription;Glucocorticoid Receptor;Glucocorticoids;glucose disposal;glucose metabolism;glucose uptake;Goals;Health;Hormones;Hydrocortisone;Hyperactivity;Immune response;improved;in vitro Assay;in vivo;in vivo evaluation;Inflammation;Inflammatory Response;Insulin;Insulin Resistance;Interleukin-6;Left;Ligand Binding;Ligands;Link;Lung;Machine Learning;Mediating;Medicine;Mesenchymal Differentiation;Mesenchymal Stem Cells;Metabolic;Metabolism;mineralization;Mitochondria;Modeling;Molecular;molecular dynamics;Muscle;Muscle Fibers;Muscular Atrophy;NCOA2 gene;Noise;novel;novel strategies;Nuclear Receptors;Nutrient;Oral;Osteoblasts;Osteoporosis;Outcome;pain reduction;Paper;Pathway interactions;Pattern;Peptides;Phenotype;Physiological;Physiology;predictive test;Process;programs;Proliferating;Protein Synthesis Induction;Proteins;receptor;Regulation;response;restraint;scaffold;Series;Shapes;side effect;Signal Pathway;Signal Transduction;Skeletal Muscle;small molecule;Statistical Data Interpretation;stem cell differentiation;Steroid Receptors;Stress;stressor;structural biology;Structure;Systems Biology;T cell differentiation;T cell regulation;T-Lymphocyte;Techniques;Testing;therapy outcome;Tissues;tool;transcription factor;Transcriptional Regulation;ultra high resolution;Work

PROJECT_TITLE: Tissue Selective Glucocorticoids


ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: Project Narrative This T32 application entitled “Clinical Research and Epidemiology in Diabetes and Endocrinology Training Grant” aims to expand the impact of our rigorous research training of pre- and post-doctoral fellows. We will address a critical need for outstanding researchers and leaders who will impact the field of diabetes, diabetes prevention and metabolic disease throughout the life course and in vulnerable populations disproportionately affected by diabetes and endocrine diseases.

PI_NAMEs: BENNETT, WENDY LYNET;BROWN, TODD T (contact);MAGGE, SHEELA NATESH

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: clinical epidemiology;Clinical Research;Diabetes Mellitus;Endocrinology

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Mental Health;Mental Illness;Precision Medicine;Schizophrenia;Serious Mental Illness

PHR: Project Narrative Schizophrenia is a highly disabling and heritable condition that affects ~1% of the global population. In this study, we will use whole genome sequencing to study rare and common genetic variation in extremely treatment-resistant schizophrenia (ETRS) individuals. The results of this study have the potential to change the clinical management of severe schizophrenia and shed light onto the biologic basis of schizophrenia, opening pathways for novel therapeutic development.

PI_NAMEs: ZOGHBI, ANTHONY  (contact)

PROJECT_TERMS: Academic Medical Centers;actionable mutation;Acute Intermittent Porphyria;Affect;Antipsychotic Agents;autism spectrum disorder;Biological;Biology;Blindness;career;Caring;Clinical;Clinical Management;Clinical Research;clinically actionable;cognitive testing;cohort;Communities;Complex;Control Groups;Copy Number Polymorphism;Country;Data;Databases;Diabetes Mellitus;Diagnosis;Diagnostic;disabled;Disabling;Disease;DNA;Doctor of Philosophy;dosage;Drug Kinetics;Exclusion;Family;Functional disorder;Genes;Genetic;genetic architecture;Genetic Counseling;genetic disorder diagnosis;Genetic study;genetic variant;Genetic Variation;Genome;genome sequencing;Genomic medicine;Genomics;Goals;Heritability;Heterogeneity;High Prevalence;Hospitalization;Impaired cognition;improved;Individual;Inpatients;insight;Institutionalization;Light;loss of function;Malignant Neoplasms;Medicine;Mendelian disorder;Mental disorders;Mental Health;mental state;Mentorship;Microarray Analysis;molecular subtypes;Mutation;Neimann-Pick's Disease Type C;new therapeutic target;New York;novel therapeutics;Oncology;Participant;Pathogenicity;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacogenetic variants;Phenotype;polygenic risk score;Population;precision medicine;Prevalence;Psychiatrist;Psychiatry;psychogenetics;rare variant;recruit;Research;Research Methodology;Research Personnel;Resistance;Risk;risk variant;Sample Size;Sampling;Schizophrenia;Seizures;Severities;Single Nucleotide Polymorphism;Symptoms;System;Testing;therapeutic development;therapy resistant;Training;Variant;whole genome;Work

PROJECT_TITLE: Uncovering the genetic architecture of extremely treatment-resistant schizophrenia using whole genome sequencing

STUDY_SECTION: GHD

STUDY_SECTION_NAME: Genetics of Health and Disease Study Section[GHD]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Mental Health;Neurosciences

ORG_CITY: Nashville

ORG_DEPT: PSYCHOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

PHR: PROJECT NARRATIVE The primary aim of this interdisciplinary training program is to provide a strong foundation in research design, quantitative methods, and critical thinking. Trainees will develop independent programs of research for the purpose of (a) discovering the neurobiological and psychosocial mechanisms underlying the development and maintenance of psychopathology, and (b) translating this basic knowledge into empirically-based interventions that reduce current and future psychopathology and promote mental health and adaptation.

PI_NAMEs: HUMPHREYS, KATHRYN LEIGH (contact)

PROGRAM_OFFICER_NAME: BECHTHOLT, ANITA JEAN

PROJECT_TITLE: Development of Psychopathology: From Brain and Behavioral Science to Intervention


NIH_SPENDING_CATS: Diabetes;Neurosciences;Obesity

ORG_CITY: STONY BROOK

ORG_DEPT: CHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Diabetes has reached epidemic proportions in the United States. The process of pancreatic amyloid formation by the polypeptide hormone IAPP is toxic to the insulin producing beta-cells and contributes to type-2 diabetes. This research will define the determinates of IAPP amyloid formation and toxicity.

PI_NAMEs: RALEIGH, DANIEL P (contact)

PROGRAM_OFFICER_NAME: CHO, THOMAS Y

PROJECT_TERMS: Acceleration;Address;Alzheimer's Disease;Amino Acids;Amyloid;Amyloid Fibrils;amyloid formation;Amyloidosis;analog;Anti-Obesity Agents;autocrine;Beta Cell;beta pleated sheet;Biochemistry;Biological Assay;biophysical analysis;Biophysics;Cardiovascular system;Cell Physiology;Cells;Cellular biology;Cessation of life;Clinical;Code;Collaborations;Complications of Diabetes Mellitus;cytotoxic;Data;Dependence;Deposition;design;Development;Diabetes Mellitus;diabetes risk;Disease;Disease Progression;Endocrine;Epidemic;Failure;Functional disorder;Funding;glucose metabolism;Goals;Hormone replacement therapy;Hormones;Human;Hydrogen Bonding;In Vitro;Individual;insight;Insulin;Insulin-Dependent Diabetes Mellitus;interest;islet;islet amyloid polypeptide;Islet Cell;Islets of Langerhans;Islets of Langerhans Transplantation;Isotope Labeling;Link;Metabolic;Metabolic Diseases;Metabolic hormone;Methods;Molecular;Molecular Conformation;mutant;Mutation;next generation;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Pancreas;paracrine;Pathologic;Play;Polypeptide Hormones;preservation;Process;programs;Proline;protein aggregation;Proteins;proteotoxicity;Rationalization;Regulation;Research;Risk;Role;Scanning;Solubility;Structural Models;Structure;Structure of beta Cell of islet;Testing;Therapeutic Agents;therapeutic target;Time;Toxic effect;treatment strategy;type I and type II diabetes;United States;Variant;Work

PROJECT_TITLE: Biophysical Studies of Amyloid Formation by Polypeptide Hormones


ORG_CITY: NEW HAVEN

ORG_DEPT: DERMATOLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative Sarcoidosis is an idiopathic inflammatory disorder characterized by granuloma formation in affected tissues and current treatments are unsatisfactory, although Janus kinase inhibitors are a promising new approach. We will perform translational immunologic research including single cell RNA sequencing and spatial transcriptomics to delineate the key cytokine signals that drive granuloma formation and how they are inhibited by JAK inhibition. These efforts will advance our understanding of sarcoidosis and help identify additional targeted strategies for treating this disease.

PI_NAMEs: DAMSKY, WILLIAM  (contact)

PROGRAM_OFFICER_NAME: GONDRE-LEWIS, TIMOTHY A

PROJECT_TERMS: Adverse effects;Affect;African American population;Area;Attention;Automobile Driving;autoreactivity;biobank;Biopsy;Blood specimen;Body System;career development;Case Study;CCL4 gene;CD4 Positive T Lymphocytes;cell type;Cells;Characteristics;chemokine;Chronic;Chronic Disease;Clinical;Clinical Trials;comparison control;Cutaneous Sarcoidosis;cytokine;Cytokine Signaling;design;Development;Disease;effective therapy;efficacy evaluation;Endothelial Cells;Enrollment;Environment;experience;experimental study;FDA approved;Fibroblasts;Freezing;Future;Granulocyte-Macrophage Colony-Stimulating Factor;Granuloma;Granulomatous disease;Heterogeneity;Histologic;Human;IL17 gene;IL18 gene;Immune;Immunobiology;Immunohistochemistry;Immunologics;Immunology;improved;In Situ Hybridization;Individual;Inflammation;Inflammatory;inhibitor;Intercellular Fluid;interest;Interferon alpha;Interferon Type II;Interferons;Interleukin-12;Interleukin-13;Interleukin-2;Interleukin-4;Interleukin-6;JAK1 gene;Janus kinase;kinase inhibitor;Laboratories;Leadership;Ligands;Lung;lymph nodes;Macrophage;Macrophage Activation;Maps;medical schools;Methotrexate;Molecular;Molecular Target;molecular targeted therapies;monocyte;Morbidity - disease rate;mortality;novel strategies;novel therapeutic intervention;open label;Organ;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Physicians;Plasma;potential biomarker;predicting response;Prednisone;Principal Investigator;Production;Proteins;Proteomics;RANTES;receptor;recruit;Reporting;repository;Research;Research Personnel;Research Proposals;response;response biomarker;RNA;Sarcoidosis;Scientist;Signal Transduction;single-cell RNA sequencing;Site;Skin;skin biopsy;Specimen;STAT protein;systemic inflammatory response;T-Lymphocyte;Testing;therapeutic target;Tissues;TNF gene;Training;transcriptome;transcriptome sequencing;transcriptomics;translational immunology;treatment effect;Work

PROJECT_TITLE: Delineation of the immunobiology of sarcoidosis and characterization of the effects of Janus kinase inhibition

STUDY_SECTION: AITC

STUDY_SECTION_NAME: Allergy, Immunology, and Transplantation Research Committee[AITC]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: East Hanover

ORG_NAME: KESSLER FOUNDATION, INC.

ORG_STATE: NJ

PHR: The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.

PI_NAMEs: BOUKRINA, OLGA  (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Aphasia;Area;Award;Behavioral Research;Binding;Biomedical Research;Brain;brain based;Brain imaging;Cerebrum;Chronic;Clinical;Clinical Trials;Clinical Trials Design;Cognitive;cognitive function;cognitive rehabilitation;Computer software;Controlled Clinical Trials;Coupled;Data;design;Disease;Early Intervention;Equilibrium;experience;Feasibility Studies;Feedback;Fingers;Functional Magnetic Resonance Imaging;Goals;Hand;Hearing;Imagery;Imaging Techniques;Impairment;improved;improved outcome;Inferior;innovation;Intervention;knowledge base;Language;Language Disorders;language impairment;Lead;Learning;learning strategy;Left;Letters;Life;Linguistics;Long term disability;Magnetic Resonance Imaging;Mediating;Mentored Research Scientist Development Award;Mentors;Methods;Mission;Modeling;Motor;National Institute on Deafness and Other Communication Disorders;neural;neural network;neurobehavioral;neurofeedback;neurological rehabilitation;neuromechanism;Neuronal Plasticity;Neurosciences;novel;novel strategies;novel therapeutic intervention;Orthography;Outcome;Parietal;Parietal Lobe;Participant;patient population;Patients;Pattern;Perfusion;Persons;phonology;Population;post stroke;Procedures;Process;Productivity;Prognosis;programs;Property;Psyche structure;Quality of life;Reading;reading ability;reading difficulties;Reading Disorder;Recovery;Recovery of Function;recruit;Rehabilitation Outcome;Rehabilitation therapy;Research;Research Support;Residual state;response;Signal Transduction;skills;Smell Perception;sound;Speech;Stroke;stroke patient;stroke recovery;stroke survivor;success;Survivors;Taste Perception;Technology;Testing;Time;Training;Training Support;Visual;Voice;Work

PROJECT_TITLE: Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery

STUDY_SECTION: CDRC

STUDY_SECTION_NAME: Communication Disorders Review Committee[CDRC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: SAINT LOUIS

PHR: Project Narrative  With an estimated mortality at 400,000 deaths in 2013, worldwide, breast cancer is a leading cause of death among women. We know that aggressive “seed” cancer cells require a permissive “soil” environment to survive and grow. We have discovered that N-cadherin is present in some cells of breast tumors in mice and humans, with features that are normally seen only in bone cells. We will determine how these "bone-like" cells contribute to tumor growth and how N-cadherin restrains such action to later devise new therapeutic strategies to combat breast cancer more effectively.

PI_NAMEs: CIVITELLI, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Ablation;Affect;Attention;bone;bone cell;Bone Marrow;Breast Cancer Cell;Cadherins;Calcium;cancer cell;cancer seeding;Cause of Death;Cell Adhesion Molecules;Cell Separation;cell transformation;Cell-Cell Adhesion;Cells;Cessation of life;Clinical;Clinical Pathology;combat;Data;Development;Diphtheria Toxin;Engraftment;Environment;epithelial to mesenchymal transition;Excision;expectation;Fibroblasts;Foundations;Genes;Growth;Human;human disease;in vivo;indexing;Injections;Internal Breast Prosthesis;Interruption;Malignant Breast Neoplasm;Malignant Neoplasms;MAP Kinase Gene;Metastatic Neoplasm to the Lung;Methods;Modification;Molecular;mortality;Mus;N-Cadherin;Neoplasm Metastasis;neoplastic cell;novel marker;novel therapeutic intervention;osteogenic;Osteolytic;p38 Mitogen Activated Protein Kinase;Parabiosis;Pathway interactions;permissiveness;Phenotype;Population;Prevalence;Prognosis;programs;recruit;Relapse;Reporting;Research;Resistance;restraint;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;Soil;Structure of parenchyma of lung;subcutaneous;Testing;Tissues;transcriptomics;Translating;tumor;tumor growth;tumor microenvironment;tumor progression;tumorigenesis;tumorigenic;Women's mortality

PROJECT_TITLE: N-cadherin in Extraskeletal Osteolineage Cells Modulates Tumor Growth

STUDY_SECTION: TME

STUDY_SECTION_NAME: Tumor Microenvironment Study Section[TME]


NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: HOUSTON

PHR: Project Narrative A properly functioning cellular immune response is essential to the eradication of infectious diseases and cancer, whereas inappropriate cellular immune regulation may result in debilitating autoimmune conditions. Given that cellular immunity plays such a critical role in the disease process, a better understanding of the innate regulatory mechanisms governing cellular immunity would allow for the formulation of novel vaccine and pharmaceutical interventions that would enormously benefit human health and well-being. Completion of the work outlined herein will permit the novel regulatory role of myeloid cell CTLA-4 in immune governance to be fully elucidated, enabling enhanced treatment regimens for cancer, viral infections, and autoimmune conditions.

PI_NAMEs: DECKER, WILLIAM KARL (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Ablation;Adoptive Transfer;Age;Alopecia;Animals;Antigens;antiviral immunity;arm;ATAC-seq;Autoimmune Diseases;B-Lymphocytes;Binding;Biological;C57BL/6 Mouse;CCAAT-Enhancer-Binding Proteins;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;Cell Proliferation;Cell secretion;Cell Separation;cell type;Cells;Cellular biology;Cellular Immunity;central tolerance;Cessation of life;ChIP-seq;Coculture Techniques;Communicable Diseases;Complex;conditional knockout;CTLA4 gene;Cues;Data;Dendritic Cells;Detection;Disease;Down-Regulation;druggable target;Equilibrium;Event;Exhibits;exosome;Failure to Thrive;fluorescence imaging;Formulation;Funding;GATA3 gene;Genetic Transcription;Genomics;Health;Human;Immune;immune activation;immune checkpoint;immune function;Immune response;Immune system;immunoregulation;In Vitro;in vivo;Incubated;Infectious Agent;Interferon Type II;Intervention;ITGAX gene;knock-down;Knock-out;knockout animal;LoxP-flanked allele;Lymphocytic Infiltrate;Lymphoid;lymphoid organ;Lymphoid Tissue;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;miRNA expression profiling;monocyte;Mus;Myelogenous;Myeloid Cells;Natural Immunity;novel;novel vaccines;Pancreas;paracrine;Pathway interactions;Peripheral;Peripheral Blood Mononuclear Cell;Personal Satisfaction;Peyer's Patches;Pharmacologic Substance;Phenotype;Play;polarized cell;Population;Process;programs;Proliferating;promoter;Proteins;Publishing;Regulation;Regulatory T-Lymphocyte;Resolution;response;Role;Shapes;Signal Transduction;Small Interfering RNA;T-Lymphocyte;Testing;therapeutic target;thymocyte;Thymus Gland;Tissues;Transcriptional Regulation;transcriptome sequencing;transmission process;Treatment Protocols;Tumor Immunity;Up-Regulation;vaccination strategy;Vesicle;Virus Diseases;Work

PROJECT_TITLE: Regulation of Innate Dendritic Cell CTLA-4


NIH_SPENDING_CATS: Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: Project Narrative The goal of this project is to understand the molecular mechanisms by which a specialized niche environment controls and coordinates production of daughter cells from multiple resident stem cell populations. We focus on the fruit fly testis as a model system and through long-term live imaging of the intact niche combined with genetic manipulations we interrogate how the niche modifies an essential cellular process—cytokinesis—in one stem cell lineage to ensure coordinated release of daughters from two distinct stem cell types. Defects in modified cytokinesis and loss of coordination between stem cells leads to tumorigenesis and tissue degeneration, making it essential to understand the cell biology of stem cell coordination to gain insight into how this process becomes misregulated with disease.

PI_NAMEs: LENHART, KARI  (contact)

PROGRAM_OFFICER_NAME: SALAZAR, DESIREE LYNN

PROJECT_TERMS: Actins;adult stem cell;Area;Basic Science;Biological Models;Cell Communication;Cell Count;Cell Lineage;Cell Physiology;Cell Proliferation;Cell Separation;cell type;Cells;cofilin;Communication;Cytokinesis;Daughter;daughter cell;Defect;Disease;Drosophila genus;Enhancers;Ensure;Environment;Excision;experimental study;Failure;Feedback;fly;Foundations;Future;gene discovery;Genetic;genetic analysis;genetic manipulation;Germ Cells;Germ Lines;germline stem cells;Goals;Growth;Guanosine Triphosphate Phosphohydrolases;Hair follicle structure;Health;Hematopoietic;high resolution imaging;Homeostasis;Hour;Human;Image;imaging approach;insight;Investigation;Knowledge;Length;Ligands;Link;Maintenance;Mediating;Methods;Modeling;Modification;Molecular;Molecular Genetics;neuronal cell body;notch protein;novel;Organ;Ovary;Pathway interactions;Play;prevent;Process;Production;programs;Regulation;Rho-associated kinase;Role;serial imaging;Signal Transduction;Somatic Cell;Source;spatiotemporal;sperm cell;stem cell biology;stem cell division;stem cell niche;stem cell population;stem cell proliferation;stem cells;Structure;Supporting Cell;System;Testing;Testis;Time;tissue degeneration;Tissues;Tumor Stem Cells;tumorigenesis;Visualization;Work

PROJECT_TITLE: Mechanisms governing stem cell coordination by the niche

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: PROJECT NARRATIVE Effective and sustainable interventions to reduce cardiovascular disparities are urgently needed. The goals of this K24 are to accelerate the implementation and sustainability of proven cardiovascular disease prevention and treatments from research to practice and community settings, and to train and mentor investigators to conduct community engaged implementation research to decrease cardiovascular health disparities.

PI_NAMEs: KANDULA, NAMRATHA R (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acceleration;Address;Adolescent;Adult;Affect;American Heart Association;Asian Americans;Asian Women;Atherosclerosis;Behavior;Blood Pressure;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;cardiovascular health;Cardiovascular system;Clinical;Clinical Research;Communities;community based participatory research;community burden;community engaged research;community engagement;community partnership;community setting;contextual factors;Daughter;Death Rate;Diabetes Mellitus;Diet;disease disparity;Disparity;Disparity population;East Asian;Education;Effectiveness;effectiveness evaluation;Effectiveness of Interventions;effectiveness outcome;Enrollment;Environment;epidemiology study;Equity;Ethnic Population;Evaluation;evidence base;Evidence based intervention;exercise intervention;Family;Female Adolescents;Funding;Future;future implementation;Gender;Glucose;Goals;Health;health care availability;health disparity;health disparity populations;Health Educators;health equity;healthy lifestyle;Heart Diseases;High Prevalence;high risk;Hispanic Populations;hybrid type 1 design;Hypertension;Immigrant;Immigration;implementation evaluation;implementation outcomes;implementation research;implementation science;implementation strategy;improved;Income;Individual;Infrastructure;innovation;Intervention;Intervention Trial;Investments;Knowledge;Language;Leadership;lifestyle intervention;Link;Lipids;Measures;Mediator;medical schools;Medicine;men;Mentors;Mentorship;Methods;mid-career faculty;Midcareer Investigator Award in Patient-Oriented Research;Minority;Modeling;Mothers;National Heart, Lung, and Blood Institute;Neighborhood Health Center;Neighborhoods;next generation;Not Hispanic or Latino;Outcome;Participant;Physical activity;physical inactivity;Population;practice setting;Prevention strategy;Preventive Medicine;Public Health;racial population;Research;Research Methodology;Research Personnel;research to practice;Resources;Risk Factors;Scholarship;Science;skills;social;social determinants;social health determinants;South Asian;stakeholder perspectives;structural determinants;student mentoring;Testing;Time;Training;treatment research;United States;United States National Institutes of Health;Universities;Vulnerable Populations;Weight;Woman;Work

PROJECT_TITLE: Mentoring in community engaged implementation research to reduce cardiovascular disparities

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(OA)]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative The proposed research is relevant to public health because the study of the basic mechanisms of seizure has broad applications to neurological disease, including numerous epilepsy types, substance abuse and withdrawal syndromes. The proposal has high translational value, and is relevant to the NIH mission to gain knowledge about the nature and behavior of living systems and to apply that knowledge to improve diagnosis, prevention, and treatment of alcohol-related problems, including alcohol use disorder, across the lifespan.

PI_NAMEs: GODWIN, DWAYNE W (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: Action Potentials;addiction liability;alcohol abuse therapy;alcohol effect;alcohol exposure;alcohol related problem;alcohol use disorder;Alcohol withdrawal syndrome;Alcohols;Animal Model;Apical;Behavior;Behavioral;Benzodiazepines;Binding;Brain;Chronic;Clinical;comparison control;Complex;Coupled;Dangerousness;Data;Dendrites;Dependence;Development;Diagnosis;Dose;drinking;Drug Metabolic Detoxication;Drug Targeting;Epilepsy;epileptiform;Ethanol;experience;experimental study;FRAP1 gene;gain of function;Grant;Hippocampus;improved;In Vitro;in vivo;Incidence;Invaded;Ion Channel Protein;Knock-out;Knowledge;life span;Mediating;Membrane;Messenger RNA;Midline Thalamic Nuclei;Mission;Modeling;Molecular;Mouse Strains;Nature;Nervous System Disorder;network models;neural circuit;neuronal cell body;Neurons;novel;optogenetics;Organism;Outcome;Pathway interactions;Pattern;permissiveness;Pharmaceutical Preparations;pharmacologic;Population;Potassium Channel;Predisposition;Preparation;prevent;Prevention;Procedures;Property;Protein Synthesis Inhibitors;Proteins;Public Health;Pyramidal Cells;Repression;Research;response;Seizures;Signal Transduction;Sirolimus;Structure;Substance abuse problem;Substance Withdrawal Syndrome;success;Symptoms;Synapses;T-Type Calcium Channels;Testing;Thalamic structure;Time;Toxic effect;Translational Repression;Translations;transmission process;United States National Institutes of Health;Up-Regulation;voltage;voltage clamp;Withdrawal;Withdrawal Symptom;Work

PROJECT_TITLE: Mechanisms of Alcohol Withdrawal

STUDY_SECTION: NAL

STUDY_SECTION_NAME: Neurotoxicology and Alcohol Study Section[NAL]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Mental Health;Neurosciences;Pediatric;Prevention;Sleep Research;Substance Misuse;Underage Drinking

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Heavy alcohol drinking during adolescence is known to disturb brain development and functioning and increase risk of drinking problems in adulthood, but the extent of the lingering effects of youthful drinking on adult functioning remains unclear. The goal of NCANDA-A (Adulthood) is to determine how adolescent alcohol-related disruption of normal brain growth patterns of brain structure, function, and psychiatric health affects abilities in emerging adulthood. Determining which affected processes remain impaired and which escape alcohol's untoward effects will specify how a youthful drinking history influences quality of life in adulthood, information obtained only from longitudinal study as proposed by NCANDA-A.

PI_NAMEs: TAPERT, SUSAN F (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: 21 year old;Abstinence;Acceleration;Acute;Adolescence;Adolescent;adolescent binge drinking;Adult;Adverse effects;Affect;Affective;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol expectancy;alcohol use disorder;alcohol use initiation;Alcohols;Behavioral;binge drinking;Biological;Brain;Clinical;Cognition;Cognitive;cognitive control;cognitive performance;cohort;Communities;Computers;COVID-19 impact;COVID-19 pandemic effects;cue reactivity;Data;design;Development;Distress;Dose;drinking;drinking onset;early onset;Economics;Elements;emerging adult;emerging adulthood;Emotional;Event;experience;externalizing behavior;Family;Female;follow-up;Frequencies;Functional Magnetic Resonance Imaging;Goals;gray matter;Growth;Health;heart function;Heart Rate;Heavy Drinking;Home;Impairment;improved;Individual;information processing;Learning;Life;Life Stress;Link;Longitudinal Studies;Machine Learning;Magnetic Resonance Imaging;male;Measures;Mediating;medical specialties;Memory;Mission;mobile application;Modeling;modifiable risk;Monitor;multimodal neuroimaging;neural;neurodevelopment;neuroimaging;neuropsychiatry;novel;Outcome;Outcome Measure;pandemic disease;Patient Recruitments;Pattern;Personal Satisfaction;Persons;Physical activity;Polysomnography;Positioning Attribute;post-pandemic;pre-pandemic;Process;Protocols documentation;Psychopathology;Psychosocial Factor;Quality of life;Recording of previous events;Recovery;recruit;Research Project Grants;response;Rest;retention rate;Risk;Risk Factors;Sampling;Schools;Sex Differences;Sex Differentiation;Site;Sleep;Sleep disturbances;social;Specific qualifier value;Stress;Structure;Symptoms;System;Technology;Testing;underage drinking;Work

PROJECT_TITLE: National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA): San Diego Research Project Site