NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Cancer;Clinical Research;Complementary and Integrative Health;Disability Research;Machine Learning and Artificial Intelligence;Mental Health;Networking and Information Technology R&D (NITRD);Post-Traumatic Stress Disorder (PTSD);Rehabilitation

ORG_STATE: NC

PI_NAMEs: ROBERTS, DAVID L (contact)

PROGRAM_OFFICER_NAME: WOLFF-HUGHES, DANA L

PROJECT_TERMS: Affect;American;analytical method;animal efficacy;Animal Structures;animal-assisted therapy;Animals;arm;arm movement;Assisted Living Facilities;base;Behavior;behavior measurement;Behavioral;Blood Pressure;Cancer Patient;Canis familiaris;Cellular Phone;Chest;Chronic;computer science;Computer software;Custom;Data;Data Analyses;Data Analytics;Data Collection;data streams;Detection;Development;Devices;Distress;Effectiveness;Electrical Engineering;Electrocardiogram;Electrodes;Elements;Environment;Evaluation;Fatigue;Focus Groups;Future;Goals;graph neural network;Health;Heart Rate;Home environment;Hospitals;Human;Hydrocortisone;improved;improved outcome;in vivo;Individual;Information Systems;innovation;Instruction;Internet of Things;Intervention;Intervention Studies;Knowledge;laptop;Lead;Machine Learning;Malignant Neoplasms;Measurement;Measures;Medical;Mental disorders;Methodology;Methods;Modeling;Monitor;Movement;Noise;novel;Oncology;Outcome;Outcome Assessment;Pain;Patient Self-Report;Patient-Focused Outcomes;Patients;Peer Review;Performance;Personal Satisfaction;Physiologic Monitoring;Physiological;Physiological Processes;Physiology;Play;Population;Post-Traumatic Stress Disorders;Posture;Process;programs;Protocols documentation;Provider;psychiatric service dog;Psychiatry;psychologic;Psychophysiology;Publishing;Qualitative Methods;real time monitoring;Research;respiratory;Retinal blind spot;Role;Safety;Schools;sensor;Service animal;Standardization;statistical and machine learning;statistics;success;symposium;Symptoms;System;systematic review;Techniques;Testing;theories;Therapeutic;therapy design;therapy development;therapy outcome;tool;Veterans;Veterinary Medicine;Visit;wearable device;wireless sensor;Work;wristband

PROJECT_TITLE: SCH: Synchronous Dyadic Physiological Monitoring for Real Time In Vivo Measurement and


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Depression;Emerging Infectious Diseases;Infectious Diseases;Mental Health;Mental Illness;Physical Activity;Prevention

ORG_CITY: PITTSBURGH

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PSYCHIATRY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRATIVE As an Early-Stage Investigator implementing my first R01 during COVID-19, I experienced significant setbacks in terms of my ongoing research (R01 MH 118270) and career trajectory. This Administrative Supplement will permit me to overcome some of those setbacks by allowing me to complete follow-up for 45 individuals and analyzing the parent study aims as planned. Completion of follow-up are critical not only for project success and NIMH’s return on investment but also my career advancement in which I plan to build upon this study and continue to develop behavioral interventions for reducing depression in older adults.

PI_NAMEs: STAHL, SARAH T (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Acute;Administrative Supplement;Adult;behavior influence;Behavior Therapy;career;Career Mobility;circadian;Collaborations;Communities;COVID-19;COVID-19 pandemic;Data;depressive symptoms;Development;digital health;Distress;efficacy evaluation;Enrollment;Environment;Event;exhaust;experience;follow-up;Funding;Future;Geographic Locations;Grant;healthy lifestyle;Hour;Individual;Intervention;Investments;late life;Life;lifestyle intervention;Mental Depression;National Institute of Mental Health;older adult;Parents;Participant;Persons;Phase;Physical activity;post intervention;prevent;Productivity;Protocols documentation;Quarantine;recruit;reduce symptoms;Research;Research Personnel;Research Project Grants;Risk;Sampling;Secure;Sleep;Social Distance;Spouses;success;technology intervention;Testing;Time;timeline;Training;United States;virtual;Wages

PROJECT_TITLE: Efficacy of a Healthy Lifestyle Intervention to Prevent Depression in Older Spousally bereaved Adults - Supplement


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Immunotherapy;Orphan Drug;Rare Diseases

ORG_CITY: CLEVELAND

ORG_DEPT: GENETICS

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: NARRATIVE Despite the significant improvement in survival for patients with colorectal cancer deficient in DNA mismatch repair using cancer immunotherapy, up to half of these patients do not derive durable clinical benefit from immunotherapy. The mechanisms associated with resistance to immunotherapy in dMMR colorectal cancer are not clearly defined. We will study factors that mediate resistance to immunotherapy in order to develop strategies to improve the clinical efficacy of immunotherapy for patients with cancer.

PI_NAMEs: WANG, ZHENGHE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: cancer immunotherapy;Clinical;clinical efficacy;colon tumorigenesis;Colorectal Cancer;colorectal cancer treatment;Combined Modality Therapy;Data;design;DNA;effective therapy;Effectiveness;gene editing technology;Generations;Genes;Goals;Immune system;Immunotherapy;improved;interest;Intrinsic factor;Malignant Neoplasms;Mediating;Mismatch Repair;Mismatch Repair Deficiency;Molecular;mouse model;Mutation;Neoadjuvant Therapy;neoantigens;Patients;Phosphotransferases;prevent;Proteins;Resistance;Resistance development;Role;Signal Pathway;standard of care;tumor

PROJECT_TITLE: Role of Erbb3 kinase activity in colorectal tumorigenesis.


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Women's Health Research

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

ORG_STATE: CT

PI_NAMEs: NABAVI, SHEIDA  (contact);YANG, CLIFFORD

PROGRAM_OFFICER_NAME: ZHU, CLAIRE

PROJECT_TERMS: 3-Dimensional;Accounting;Address;adversarial learning;Age;Algorithms;American Cancer Society;Artificial Intelligence;artificial intelligence algorithm;Artificial Intelligence enhanced;artificial intelligence model;Attention;biomedical imaging;brain magnetic resonance imaging;Breast Cancer Detection;breast cancer diagnosis;burden of illness;Cancer Detection;cancer imaging;Clinical;Clinical Data;clinical decision-making;clinical risk;Complex;computer aided detection;cost;Data;Databases;deep learning;deep learning model;detection platform;Development;Diagnosis;Diagnostic;Digital Breast Tomosynthesis;Digital Imaging and Communications in Medicine;Early Diagnosis;Ensure;Face;Feedback;global health;Goals;Graph;graph learning;graph neural network;Health Care Costs;Healthcare Systems;Human;Image;Image Analysis;improved;Individual;innovation;Intelligence;Learning;Low Prevalence;Malignant Breast Neoplasm;Malignant Neoplasms;Mammography;meetings;Memory;Methods;Modeling;mortality;multimodality;novel;operation;Outcome;Patient-Focused Outcomes;Patients;Performance;pragmatic implementation;radiologist;Recommendation;Recording of previous events;Research;Resolution;Risk;Risk Factors;routine screening;Sample Size;Scanning;screening;self supervised learning;self-attention;Slide;System;Tissues;Training;Update;Variant;Woman;Workload;X-Ray Computed Tomography

PROJECT_TITLE: SCH: Robust Multimodal Longitudinal AI for Enhanced Breast Cancer Screening

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IVBH-N (50)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention

ORG_CITY: ATLANTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: RELEVANCE (See instructions): The proposed efficient, explainable Al techniques aim to reduce overdiagnosis and unnecessary monitoring, especially in high-risk groups. These technologies are crucial for assessing tumor responses to cancer treatments, offering widespread benefits to public health.

PI_NAMEs: ZHAO, LIANG  (contact)

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: 3-Dimensional;Acceleration;Active Learning;Address;Architecture;Artificial Intelligence;artificial intelligence model;Biopsy;cancer diagnosis;Cancer Diagnostics;cancer imaging;cancer therapy;Chemotherapy-Oncologic Procedure;Clinical Data;Collaborations;Communication;computer framework;Consensus;cost;Data;data complexity;data privacy;Data Set;Decision Making;Devices;Diagnosis;Diagnostic Imaging;Dimensions;Early Diagnosis;Early identification;Educational process of instructing;explainable artificial intelligence;federated learning;frontier;high risk;high risk population;Human;Image;image reconstruction;Imaging technology;improved;Institution;Instruction;Intelligence;Knowledge;Learning;Logic;Magnetic Resonance Imaging;Malignant neoplasm of abdomen;Medical;Modality;model generalizability;Modeling;Monitor;multimodal data;open source tool;Pathway interactions;Play;preference;privacy preservation;Process;prompt engineering;Public Health;Radiation therapy;Research;Research Personnel;Resources;response;Risk;Risk Management;Role;routine screening;Sampling;Scanning;screening;Screening for cancer;Students;Supervision;Symptoms;System;Techniques;Technology;Testing;Time;Training;training data;tumor;Tumor Markers;Uncertainty;Visual

PROJECT_TITLE: SCH: Visual explanation-guided learning for human-AI collaborative abdominal cancer diagnostic imaging


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_CITY: MINNEAPOLIS

ORG_NAME: HENNEPIN HEALTHCARE RESEARCH INSTITUTE

ORG_STATE: MN

PHR: PROJECT NARRATIVE Blood-based ADRD biomarkers show tremendous promise as a non-invasive method to predict and diagnose ADRD. In a community population of 21,000 older persons without dementia, we will measure changes in these biomarkers over 7 to 10 years, to determine whether their ability to predict ADRD differs by sex or by other characteristics, and develop a sex-specific ADRD risk score for personalized medicine and clinical trials.

PI_NAMEs: MIELKE, MICHELLE M;MURRAY, ANNE M (contact);RYAN, JOANNE

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Address;adjudication;Affect;Age;aged;Alcohol consumption;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;apolipoprotein E-4;Australia;Biological Markers;Black American;Black Populations;Blood;blood pressure variability;Blood specimen;blood-based biomarker;Cardiovascular Diseases;Characteristics;Chronic;Clinic;Clinical;clinical diagnostics;clinical practice;Clinical Trials;Cognition;cognitive change;cognitive function;cognitive testing;cohort;Collection;Communities;comorbidity;cost efficient;Data;Dementia;dementia risk;design;Development;Diabetes Mellitus;Diagnosis;diagnostic tool;Disease Progression;Education;Enrollment;Ethnic Origin;executive function;Funding;Gender;Genetic;genetic risk factor;Genomics;Glial Fibrillary Acidic Protein;Health;high school;human old age (65+);Hypertension;Impaired cognition;Individual;insight;Knowledge;late life;Life Style;Light;Longitudinal Studies;Measures;men;Mental Depression;Methods;Minority;Modeling;Nerve Degeneration;neurofilament;Non-Invasive Detection;novel;older adult;Older Population;Outcome;Participant;Pathology;personalized medicine;personalized strategies;Persons;Phenotype;Physical activity;Plasma;polygenic risk score;Population;population based;Positioning Attribute;predictive modeling;Prevalence;Prevention;preventive intervention;processing speed;Prognosis;prognostic tool;prospective;Race;Reference Values;Reporting;Research;Risk;Risk Factors;risk prediction;risk prediction model;Sampling;screening;sex;Sex Differences;sex variable;Smoking;social;Socioeconomic Status;Symptoms;tau Proteins;tau-1;Technology;Time;tool;Woman

PROJECT_TITLE: Sex-specific risk factors and trajectories of blood biomarkers for Alzheimer's disease and related dementias


ORG_CITY: STANFORD

ORG_DEPT: CHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Project Narrative - Mucins are heavily glycosylated proteins that have been known to play roles in inflammation and cancer with potential to be therapeutic targets for future treatments1. The proposed project will work towards the development of a new mucin-selective enrichment strategy for mass spectrometry analysis of the “mucinome” by utilizing a novel proximity labeling approach6. To do this, I will develop a StcE[E447D] mucinase conjugate, validate utilizing glycoproteomics, and finally, develop a library of inactive mucinases with photocatalyst conjugates.

PI_NAMEs: BERTOZZI, CAROLYN  (contact)

PROGRAM_OFFICER_NAME: MARQUEZ, GUILLERMO

PROJECT_TERMS: Administrative Supplement;Binding;Biological;Biotin;cancer cell;Cell model;Chemicals;Code;Development;Diagnostic;Diazomethane;Engineering;Environment;Foundations;Future;Glycopeptides;glycoproteomics;glycosylation;Health;Human;Inflammation;Investigation;Iridium;Isotopes;Knowledge;Label;Libraries;Malignant Neoplasms;Mass Spectrum Analysis;Methods;mucinase;Mucins;novel;Oncogenes;parent grant;Play;polypeptide;Polypeptide N-acetylgalactosaminyltransferase;prostate cancer cell;prostate cancer cell line;Protein Glycosylation;Proteins;Proteolysis;Reaction;Research;Role;Scanning;Techniques;technology development;Tertiary Protein Structure;Therapeutic;therapeutic target;undergraduate research;Work

PROJECT_TITLE: Chemical glycoproteomics

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: AUSTIN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

ORG_STATE: TX

PI_NAMEs: JIA, YAOYAO  (contact)

PROGRAM_OFFICER_NAME: LIU, SONGTAO

PROJECT_TERMS: Acute;Address;Adopted;Ambulatory Blood Pressure Monitoring;Ambulatory Monitoring;analog;Anatomy;Arterial Lines;Arteries;biomechanical model;Biomechanics;Blood Pressure;Blood Pressure Monitors;Blood Vessels;Blood Volume;Bypass;Calibration;Cardiac;Cardiovascular Diagnostic Techniques;Cardiovascular Diseases;Cardiovascular system;Catheters;Child;Childhood;Clinical;clinical decision-making;Coagulation Process;cost;data acquisition;Dedications;design;Devices;Diameter;Early Diagnosis;Electronics;feature extraction;Friends;General Population;Goals;healthcare burden;hemodynamics;Hospitals;Hypertension;Infection;innovation;Instruction;integrated circuit;Intensive Care;Machine Learning;machine learning model;Measurable;Measurement;Measures;Mechanics;Medical;Medical center;Methodology;Methods;millimeter;Mission;Modality;Modeling;Modernization;Monitor;monitoring device;mortality;Motivation;National Heart, Lung, and Blood Institute;Nursing Records;Outpatients;Paint;Patient Monitoring;Patients;Performance;Photoplethysmography;Physiologic pulse;Population;power consumption;Predisposition;Preventive;Preventive measure;Process;Risk;Screening procedure;sensor;Signal Transduction;Societies;Source;Sphygmomanometers;Surface;Symptoms;System;Tattooing;technology development;temporal measurement;Thick;Time;time interval;training data;Translational Research;trend;Ultrasonics;ultrasound;United States;usability;user-friendly;Validation;Variant;virtual patient;wearable device;wireless;wireless sensor;Wrist

PROJECT_TITLE: SCH: A biomechanics-guided wireless ultrasonic e-tattoo with an application specific integrated circuit for ambulatory blood pressure monitoring


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Clinical Research;Data Science;Emergency Care;Health Services;Hematology;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Sepsis

ORG_CITY: Columbus

ORG_DEPT: MISCELLANEOUS

ORG_NAME: OHIO STATE UNIVERSITY

PI_NAMEs: CATERINO, JEFFREY M;PADILLA, LACE M.;WANG, DAKUO ;ZHANG, PING  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Accident and Emergency department;Acute Disease;Acute Renal Failure with Renal Papillary Necrosis;Address;Algorithm Design;Algorithms;Articulation;Artificial Intelligence;Bacteria;biomedical informatics;Caring;Clinical;clinical application;clinical decision support;Clinical Decision Support Systems;clinical decision-making;clinical outcome measures;clinical practice;Code;Collaborations;Communities;computer human interaction;computer science;Confidence Intervals;COVID-19;Critical Care;Data;data de-identification;Data Set;data visualization;Databases;Death Rate;Decision Making;deep learning;deep learning algorithm;design;Development;Diagnosis;Documentation;Early Intervention;Educational process of instructing;Effectiveness;Electronic Health Record;electronic health record system;Emergency Medicine;Evaluation;experimental study;Expert Systems;explainable artificial intelligence;fungus;Future;graduate student;Hospitalization;Hospitals;Hour;Human;improved;innovation;insight;Instruction;intelligent algorithm;Intensive Care Units;Internships;Life;Machine Learning;machine learning algorithm;machine learning model;Measures;Medical;Medicine;Methodology;Mission;Modeling;Myocardial Infarction;National Institute of Allergy and Infectious Disease;novel;open source;Outcome;Output;outreach;Patients;Physicians;predictive modeling;Procedures;Process;programs;Public Health;Recommendation;Recording of previous events;Records;Research;Risk;risk prediction model;satisfaction;Schools;Sepsis;septic patients;support tools;System;Testing;tool;Training;Treatment Cost;trustworthiness;Uncertainty;undergraduate student;Underrepresented Students;usability;user-friendly;Virus;Visit;Visualization;Visualization software;ward;Work

PROJECT_TITLE: SCH: Improving Early Prediction and Decision-Making for Sepsis with Human-AI Collaboration


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Cancer;Precision Medicine;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

ORG_STATE: NY

PHR: NARRATIVE The advent of molecular imaging has prompted a paradigm shift in medical imaging as a whole, from its foundations in purely anatomical imaging towards techniques aimed at probing tissue phenotype and function. We have for many years exploited aberrant targets associated with cancer in order to better diagnose, stage and monitor this disease. In this R35, we plan to highlight three highly integrated areas within the context of our expertise and insights that will have a significant impact on cancer treatment outcomes.

PI_NAMEs: LEWIS, JASON S. (contact)

PROGRAM_OFFICER_NAME: WANG, YISONG

PROJECT_TERMS: Address;anatomic imaging;Area;Biology;Cancer Biology;cancer imaging;cancer therapy;Chemicals;Chemistry;Clinic;clinical translation;detector;Development;Diagnosis;Discipline;Disease;Engineering;Foundations;Genomics;Human;Image;imaging agent;Imaging technology;improved;in vivo imaging;insight;Label;Laboratories;Malignant Neoplasms;Measures;Medical Imaging;Methodology;Methods;Molecular;molecular imaging;Monitor;new therapeutic target;non-invasive imaging;novel;Organism;Pathway interactions;Pharmacology;Phenotype;pre-clinical;predicting response;programs;Prostate Cancer therapy;Radiochemistry;response;Techniques;theranostics;Time;Tissues;Translating;translational research program;Treatment outcome;tumor heterogeneity;Visualization;Work

PROJECT_TITLE: Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate Cancer


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative: This application is a diversity supplement request for PA-23-189 for Rachel Ofer, under award R01CA190558- 06A1 Mechanisms of Serrated Colon Tumor Suppression, (Verzi , Michael, PI). Ms. Ofer’s research aims to uncover metabolic vulnerabilities in colon tumors that can be targeted therapeutically.

PI_NAMEs: VERZI, MICHAEL P. (contact)

PROGRAM_OFFICER_NAME: FINGERMAN, IAN M

PROJECT_TERMS: Ammonia;ApcMin/+ mice;ARG2 gene;Arginine;ATAC-seq;Award;Binding;Biological Assay;Biomass;BRAF gene;Breeding;cancer initiation;cancer therapy;Carcinoma;CDX2 gene;Cells;Chromatin;Clinic;Colon;colon cancer prevention;Colon Carcinoma;colon growth;colon tumorigenesis;Colonic Neoplasms;Colorectal Cancer;Data;Data Analyses;Detection;Development;Drug Metabolic Detoxication;Drug Targeting;druggable target;Early Diagnosis;Education;Environment;Enzymes;epigenomics;Epithelial Cells;Epithelium;experimental study;Gene Expression;Genes;Genetic;Genetic Models;Genetic Transcription;Genome;Goals;Grant;Growth;Hour;Human;Immunohistochemistry;in vivo;injury and repair;innovation;Intestinal Diseases;Isotope Labeling;Isotopes;Knowledge;MADH4 gene;Malignant Neoplasms;Maps;Measurement;Measures;Metabolic;Metabolism;metabolome;metabolomics;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Mutation;neoplastic cell;novel therapeutics;Nuclear;Oncogenic;Organoids;Ornithine;parent project;Pathway interactions;Patients;permissiveness;Polyamines;Pre-Clinical Model;Predisposition;Prevention strategy;Production;Proliferating;protein expression;Proteins;rapid growth;Research;response;Role;Sampling;Scientist;Screening for cancer;single-cell RNA sequencing;skills;stem cell biomarkers;stem cell division;stem cells;targeted treatment;Technology;Testing;therapeutic evaluation;Therapeutic Intervention;Toxic effect;Training;transcription factor CDX2;transcriptome;transcriptome sequencing;Translating;Translational Research;tumor;tumor growth;tumor initiation;tumor metabolism;tumor microenvironment;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;Urea;urea cycle;Work

PROJECT_TITLE: (2R01CA190558-06A1; Div Suppl) Mechanisms of Serrated Colon Tumor Suppression Diversity Supplement

STUDY_SECTION: GRIC

STUDY_SECTION_NAME: Gene Regulation in Cancer Study Section[GRIC]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Digestive Diseases;Esophageal Cancer;Genetics;Human Genome;Infectious Diseases;Rare Diseases;Stomach Cancer

ORG_DEPT: SURGERY

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE We will integrate novel mouse models, organotypic cultures of human and mouse cells and state-of-the-art single cell profiling and spatial transcriptional data to address fundamental questions regarding the cell of origin of distinct classes of gastric cancer. In parallel, we will define key transcriptional mediators of the progression to gastric cancer and then perform experimental validation. Together these studies can integrate addressing longstanding debates over origins of gastric cancer while defining targets to prevent cancer initiation.

PI_NAMEs: MANIATIS, SILAS ;NOWICKI-OSUCH, KAROL PIOTR;RYEOM, SANDRA  (contact)

PROGRAM_OFFICER_NAME: YASSIN, RIHAB R

PROJECT_TERMS: Address;Angiogenic Factor;Attenuated;Cadherins;Cancer Etiology;cancer initiation;candidate validation;CD44 gene;cell type;Cells;Cessation of life;Characteristics;Chromatin;Chromosomal Instability;Complex;Coupled;Data;Development;dietary;dietary nitrate;Diffuse;Diffuse gastric cancer;DNA Sequence Alteration;E-Cadherin;Endothelial Cells;Engineering;Environmental Exposure;Environmental Risk Factor;Epigenetic Process;epigenomics;Epithelial Cells;Epithelium;Esophageal Adenocarcinoma;Esophagogastric Junction;Esophagus;Evolution;Exposure to;Extracellular Matrix;functional genomics;gastric corpus;gastric intestinal metaplasia;gastric tumorigenesis;gastroesophageal adenocarcinoma;gastroesophageal cancer;Gene Expression Profiling;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome editing;Genome Stability;genomic aberrations;Genomics;Helicobacter;Helicobacter Infections;Helicobacter pylori;Histologic;Human;human tissue;Immune;In Vitro;in vivo;Individual;insight;Intervention;Intestines;Lesion;Link;Malignant - descriptor;Malignant neoplasm of esophagus;Malignant Neoplasms;malignant stomach neoplasm;Maps;Mediating;Mediator;member;Modeling;Molecular;molecular subtypes;mouse model;multiple omics;Mus;Mutation;Myeloid Cells;Myeloid-derived suppressor cells;Neoplasms;neoplastic;Nerve Growth Factors;Nitrates;Nomenclature;novel;Organoids;Phenotype;Population;prevent;Process;programs;Role;Signal Transduction;single cell analysis;single cell technology;Stomach;stomach cardia;System;Technology;Testing;Time;Tissue Sample;Tissues;tool;TP53 gene;transcriptomic profiling;transcriptomics;tumor progression;Tumor Promotion;Tumor Suppressor Proteins;Uncertainty;Validation;Variant

PROJECT_TITLE: Elucidating the mechanisms by which the extracellular matrix contribute to gastroesophageal cancer pathobiology


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Mental Health;Prevention;Sexually Transmitted Infections;Social Determinants of Health;Violence Research

ORG_CITY: SAN DIEGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: PROJECT NARRATIVE Sexual minority men (SMM) experience intimate partner violence (IPV) at alarming rates and prior work has linked IPV with sexual risk-taking behavior and to increased risk for HIV seroconversion among SMM, but less is known about the impact of IPV on HIV testing, pre-exposure prophylaxis (PrEP) uptake, and the persistence of PrEP use among SMM. The proposed innovative observational cohort study will examine how perpetration and/or receipt of various forms of IPV (e.g., physical, sexual, and psychological; in the context of steady or casual intimate relationships) contribute to HIV risk and protective behaviors among HIV-negative SMM over a 24-month timeframe. This research will advance our understanding of both the risk and resiliency factors relevant to preventing and reducing IPV, reducing HIV risk behaviors, and increasing HIV protective behaviors among SMM.

PI_NAMEs: STORHOLM, ERIK D. (contact)

PROGRAM_OFFICER_NAME: SENN, THERESA ELAINE

PROJECT_TERMS: AIDS prevention;Alcohol consumption;Behavior;Buffers;Characteristics;Child Abuse;cohort;condomless anal sex;Coping Skills;Data;Development;Diagnosis;effective intervention;experience;follow-up;Frequencies;HIV;HIV risk;HIV Seronegativity;HIV Seropositivity;Human immunodeficiency virus test;Individual;innovation;Interruption;Intervention;intimate partner violence;Link;Mediating;Mental Health;minority stress;observational cohort study;Participant;Pathway interactions;pre-exposure prophylaxis;prevent;protective behavior;psychologic;psychological violence;Recommendation;Recording of previous events;Research;resilience factor;Risk;Risk Behaviors;Risk Factors;Severities;sexual minority men;sexual risk behavior;sexual risk taking;Sexually Transmitted Diseases;Social support;Substance abuse problem;substance use;syndemic;Testing;theories;uptake;Victimization;Violence;violence prevention;Work

PROJECT_TITLE: Intimate Partner Violence and HIV Prevention among Sexual Minority Men


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Cardiovascular;Clinical Research;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Emerging Infectious Diseases;Heart Disease;Heart Disease - Coronary Heart Disease;Infectious Diseases;Lung;Pain Research;Physical Activity;Post-Acute Sequelae of SARS-CoV-2 infection (PASC) including Long COVID;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: This study seeks to discover the reason patients with long COVID suffer from persistent chest pain symptoms. Using advanced magnetic resonance imaging (MRI), this study will determine: (a) whether MRI accurately and precisely detects blockage in small blood vessels supplying oxygen to the heart in long COVID patients; (b) whether the said blockage is the cause of persistent chest pain symptoms in long COVID patients; (c) whether the said blockage resolves better if patients undergo therapy. Our findings will inform future clinical trials aimed at preventing and/or reversing persistent chest pain caused by long COVID.

PI_NAMEs: KIM, DANIEL  (contact);LEE, DANIEL CHING-HAO

PROGRAM_OFFICER_NAME: HALLER, JOHN WAYNE

PROJECT_TERMS: acute COVID-19;Age;Americans with Disabilities Act;Arrhythmia;asymptomatic COVID-19;Biological Markers;Blood;Blood flow;Blood Vessels;Breathing;Cardiopulmonary;Cardiovascular Abnormalities;cardiovascular health;Cardiovascular system;Chest Pain;Chronic;Cicatrix;Classification;Clinical;Clinical Trials;Contrast Media;Control Groups;Coronary;Coronary Arteriosclerosis;cost;COVID-19;COVID-19 patient;COVID-19 survivors;Data;Detection;Development;Diagnosis;Diagnostic;Diagnostic Imaging;Diagnostic tests;Diffuse;disability;Endothelium;Enrollment;Ethnic Origin;exercise capacity;exercise intolerance;Exercise Test;extracellular;Fibrosis;Functional disorder;Future;Gadolinium;Goals;Grant;Healthcare;Heart;Heart Diseases;heart imaging;hemodynamics;Image;imaging facilities;imaging modality;improved;indexing;Inflammation;Injury;Ionizing radiation;Ischemia;Knowledge;Left Ventricular Ejection Fraction;Long COVID;Lung;Magnetic Resonance;Magnetic Resonance Angiography;Magnetic Resonance Imaging;Matched Case-Control Study;Measures;Medical Imaging;Microvascular Dysfunction;Modality;Myocardial;Myocardial perfusion;Oxygen;pain patient;pain symptom;Patients;Perfusion;perfusion imaging;Pericardial body location;persistent symptom;Positioning Attribute;post SARS-CoV-2 infection;Post-Acute Sequelae of SARS-CoV-2 Infection;prevent;Protocols documentation;pulmonary function;Race;Radioactive Tracers;Recording of previous events;Resources;Risk Factors;SARS-CoV-2 infection;Severities;sex;Stress;Symptoms;Testing;Time;tomography;United States National Institutes of Health;Vaccines

PROJECT_TITLE: Quantitative Detection of Coronary Microvascular Dysfunction in Long COVID Patients using a Comprehensive, Rapid, Free-Breathing Cardiovascular MRI

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Genetics;Liver Disease

ORG_CITY: RALEIGH

ORG_DEPT: BIOLOGY

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: PROJECT NARRATIVE Cadmium is a toxic metal that is a major public health concern, due to its ubiquity in the human environment. If successful, our work will show that exposure to cadmium during development causes non-alcoholic fatty liver disease in later life through activating a specific set of genes, identifying these genes as potential markers of disease susceptibility and novel targets for treatment. Given that NAFLD affects 30-40 % of the US adult population, and has been linked to metabolic impairments and a shorter lifespan, findings from our work have the potential to improve disease prediction and management for a large number of people.

PI_NAMEs: COWLEY, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DUNCAN, CHRISTOPHER GENTRY

PROJECT_TERMS: Adult;Affect;Alleles;Behavior Disorders;Cadmium;Cardiovascular Diseases;Cell Culture Techniques;Cell model;Chemicals;Child;Data;Deposition;Development;developmental disease;Disease;Disease Marker;Disease susceptibility;disorder prevention;DNA;DNA Methylation;Dose;Environment;Epigenetic Process;Event;Exposure to;Extracellular Matrix;Fatty acid glycerol esters;Functional disorder;Gene Activation;gene network;Genes;Genetic;Genetic Transcription;genome-wide;Health;Heavy Metals;Hepatic Stellate Cell;Hepatocyte;high risk;Human;human data;human model;Impairment;imprint;improved;in vivo;Inflammation;K-Series Research Career Programs;Kidney;Knowledge;late life;Lead;Life;life span;Link;Lipids;Liver;liver metabolism;Malignant neoplasm of liver;Metabolic;Metabolic Diseases;Metabolic syndrome;Modeling;Molecular;Molecular Profiling;Molecular Target;mouse model;Mus;National Institute of Environmental Health Sciences;Nature;new therapeutic target;Newborn Infant;non-alcoholic fatty liver disease;North Carolina;novel;Onset of illness;overexpression;Paracrine Communication;Pathway interactions;Patients;Persons;Play;Population;Pregnant Women;prevent;Production;Program Development;programs;Public Health;Relaxation;Respiratory System;Role;Skeletal system;stressor;System;Testing;Therapeutic Intervention;Tissues;Toxic effect;toxic metal;toxicant;Umbilical Cord Blood;Up-Regulation;Work;World Health Organization

PROJECT_TITLE: The Imprinted Gene Network in the programming of Non-Alcoholic Fatty Liver Disease by early life cadmium exposure

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Complementary and Integrative Health;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Hematology;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke

ORG_CITY: WORCESTER

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Six million Americans live with atrial fibrillation (AF), a heart rhythm abnormality that is a major risk factor for stroke, and only 60% of these AF patients take the recommended treatment, anticoagulation (AC). This problem is even worse for non-White patients who are at higher risk of stroke due to AF. The proposed Diversity Supplement will support an outstanding early-stage investigator to examine AC use in a diverse population of older adults while also providing mentoring and training opportunities to establish the candidate as an independent investigator.

PI_NAMEs: KAPOOR, ALOK  (contact);MCMANUS, DAVID D.

PROGRAM_OFFICER_NAME: SIDDIQUI, AYESHA SAEED

PROJECT_TERMS: Adherence;Affect;African American;African American population;Age;aging population;American;Anticoagulation;Atrial Fibrillation;Behavior;Belief;Biometry;black patient;Black race;cardiovascular health;Cardiovascular system;career;career development;Caring;Cessation of life;clinical decision support;cohort;Communities;community engaged research;Conflict (Psychology);Death Rate;Dedications;Development Plans;Disparity;Effectiveness;Electronic Health Record;Eligibility Determination;ethnic health disparity;Expenditure;experience;Faculty;Fellowship;Florida;Fostering;Funding;Geriatrics;Goals;Guidelines;Health;health belief;health disparity;health literacy;Health Personnel;Health system;heart rhythm;Hemorrhage;high risk;human old age (65+);implementation science;Incidence;Individual;Informatics;Insurance Coverage;interest;Ischemic Stroke;Knowledge;Learning;Lifelong disability;Link;Massachusetts;Measures;medical schools;Medicare;member;Mentors;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;novel;older adult;Oral;Outcome;parent project;Parents;Patients;Persons;Pharmaceutical Preparations;Phase;Physicians;Play;Population;population based;Population Heterogeneity;premature;Program Development;Provider;psychologic;Publishing;racial disparity;Recommendation;Religion;Religiosity;Religious Belief;Research;Research Methodology;Research Personnel;Risk;Risk Factors;risk perception;Role;Schedule;Scientist;Services;Site;skills;social;Spirituality;Stroke;Stroke prevention;stroke risk;support tools;Surveys;Talents;Teacher Professional Development;Telephone;therapy design;Training;training opportunity;treatment adherence;Treatment Effectiveness;Trust;Underserved Population;Universities;Vocational Guidance;Work

PROJECT_TITLE: Association of Health Belief Variables, Religiosity, and Spirituality with AC Use in Older Adults with Atrial Fibrillation

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Cancer;Hematology;Rare Diseases

ORG_CITY: PORTLAND

ORG_NAME: MAINEHEALTH

ORG_STATE: ME

PHR: Narrative In this Supplement, Ms. Karam, an under-represented minority by the NIH-guidelines, will be supported on her career path to graduate school. Her project falls within our Parent R37 grant by examining the tumor- supportive roles of the fatty acid binding proteins (FABPs) in multiple myeloma. Her project will explore the effects of FABP inhibitors in a myeloma model using a more effective and clinically-relevant dosing route than we have used before, and her results will provide novel insight into the effects of FABP inhibitors on myeloma cells as well as the other immune cells within the bone marrow and surrounding the tumor.

PI_NAMEs: REAGAN, MICHAELA R. (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: 3-Dimensional;Adipocytes;Automobile Driving;Award;bone;Bone Marrow;Cancer Model;Career Choice;career development;cell growth;Cells;Clinic;clinically relevant;Complement;Data Analyses;Development;Dose;Drug Delivery Systems;drug development;Drug resistance;Environment;FABP4 gene;FABP5 gene;falls;fatty acid-binding proteins;feasibility testing;Goals;graduate school;Grant;Growth;Guidelines;Hematopoietic Neoplasms;Immune;Immunocompetent;in vivo;inhibitor;insight;Mediator;member;Methodology;Methods;Modeling;mouse model;Multiple Myeloma;Mus;Mutation;neoplastic cell;novel;novel strategies;Oral;Oral Administration;parent project;Parents;Patients;Plasma Cells;Postbaccalaureate;Proliferating;Proteins;Research;Research Assistant;Research Project Grants;Role;Route;Science;Signal Transduction;Soil;Time;Tissue Engineering;transcriptomics;tumor;tumor microenvironment;tumor progression;tumor-immune system interactions;Underrepresented Minority;United States National Institutes of Health;Work

PROJECT_TITLE: Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma Drug Resistance - Diversity Supplement

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 1 Study Section[MCT1]


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Telehealth

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: Project Narrative Social anxiety disorder (SAD) is one of the most prevalent mental disorders, affecting 12.1% of U.S. indi- viduals at some point in their lifetime, and is characterized by fear and avoidance of socially evaluative situations, often leading to devastating consequences for the affected individual and placing considerable economic burden on society at large. The proposed study is the ﬁrst (to our knowledge) to tackle speciﬁc ethical concerns for conducting research with mobile sensing devices in individuals high in social anxiety (a group likely to have heightened concerns about being monitored), considering aspects of both users' comfort and perceptions of leveraging digital health interventions with embedded sensing, as well as the preferred methods and content of informed consent to communicate about potential risks. The outcomes of this work will contribute to best research and clinical practices in the ﬁeld of digital mental health for socially anxious individuals.

PI_NAMEs: BARNES, LAURA ELIZABETH (contact);BOUKHECHBA, MEHDI O.;TEACHMAN, BETHANY A

PROGRAM_OFFICER_NAME: LEITMAN, DAVID ISAAC

PROJECT_TERMS: Accelerometer;adaptive intervention;Address;Affect;Anxiety;anxiety states;anxious;anxious individuals;Awareness;Behavior;Behavior monitoring;Behavioral;biobehavior;Caring;Cellular Phone;Clinic;Clinical;Clinical assessments;clinical efficacy;clinical practice;Collection;Communication;Computing Methodologies;Conscious;Consent;Cost Analysis;cost effective;Data;Data Analyses;data de-identification;data privacy;Data Security;Data Set;Data Sources;data streams;design;Devices;digital health;digital mental health;Economic Burden;Emotional;Equity;Ethical Issues;Ethics;Evaluation;Fostering;Fright;Guidelines;handheld mobile device;Health Technology;high risk;Hour;improved;Individual;Informed Consent;insight;Intervention;Interview;Knowledge;Learning;Life;Mental disorders;Mental Health;Mental Health Services;Methods;mobile computing;mobile sensing;Modality;Modeling;Monitor;Outcome;parent grant;Parents;Participant;patient oriented;Patient Self-Report;Patients;Pattern;Perception;Performance;personalized intervention;Persons;Physiological;Population;preference;Preservation Technique;Privacy;privacy preservation;Privatization;Production;Protocols documentation;psychiatric symptom;Publications;Quality of life;Reaction;Research;Research Personnel;research study;Risk;risk sharing;sensor;Signal Transduction;smart device;social;social anxiety;Social Anxiety Disorder;Social Environment;social group;social interventions;Societies;Stream;stressor;Structure;System;Techniques;Technology;Testing;Time;trait;wearable device;wearable sensor technology;willingness;Work

PROJECT_TITLE: A Mixed-Methods Study of the Ethical Issues Surrounding Mobile Sensing in Digital Mental Health Interventions

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: GM

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Nutrition

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PI_NAMEs: CZUBA, LINDSAY CHRISTINE (contact)

PROGRAM_OFFICER_NAME: FRINCU, CRINA

PROJECT_TERMS: Apical;bile acid transporter;Bile Acids;Biology;Centers of Research Excellence;Chemicals;Development;glucose metabolism;Human;innovation;insight;lipid metabolism;Pharmacologic Substance;Public Health;Regulation;Research;Role;Signal Transduction;Therapeutic

PROJECT_TITLE: Mechanistic insight into the regulation of the apical bile acid transporter (ASBT) using chemical biology approaches


NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Many metastases of breast cancer may further disseminate to seed more metastases, but the pre-clinical models, the underlying mechanisms, and the potential therapeutic targets are all lacking. Herein, based on several lines of preliminary evidence, we propose to test the hypothesis that the bone microenvironment invigorates metastatic seeds for further dissemination. Specifically, we will focus on delineation of temporal course of metastatic seeding from bone to other organs, and identification of druggable pathways driving this process.

PI_NAMEs: ZHANG, XIANG  (contact)

PROGRAM_OFFICER_NAME: SNYDERWINE, ELIZABETH G

PROJECT_TERMS: Automobile Driving;bone;Brain;Breast Cancer Cell;breast cancer metastasis;cancer cell;Cessation of life;design;Destinations;Distant;druggable target;Epigenetic Process;epigenomics;Evolution;fetal;Genomics;innovation;insight;Kinetics;Lesion;limb bone;Liver;Lung;Malignant Breast Neoplasm;Metastatic Neoplasm to the Bone;Micrometastasis;Neoplasm Metastasis;novel therapeutics;Organ;Outcome;Pathway interactions;Patients;Phenotype;Pre-Clinical Model;prevent;Prevention;Primary Neoplasm;Process;Prognosis;Property;Site;Skeleton;stem;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Time;Visceral

PROJECT_TITLE: Modulation of Epigenetic Target in the Bone to Treat Breast Cancer Metastasis

STUDY_SECTION: TPM

STUDY_SECTION_NAME: Tumor Progression and Metastasis Study Section[TPM]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Lymphedema is an incurable condition that affects over 5 million individuals in the US and is characterized by tissue swelling after lymphatic node injury or resection. There is no pharmacologic therapy that is currently approved to prevent post-surgical lymphedema. Our laboratory has shown that retinoic acid therapy mitigates lymphedema after surgical injury by promoting lymphangiogenesis in multiple pre-clinical models. The objective of this proposal is to increase our understanding of the mechanisms by which retinoic acids regulate lymphangiogenesis and develop a translational framework for the clinical use of these compounds.

PI_NAMEs: WONG, ALEX K. (contact)

PROGRAM_OFFICER_NAME: GAO, YUNLING

PROJECT_TERMS: Acceleration;Address;Affect;alitretinoin;American;angiogenesis;Biology;Blood Vessels;Carrier Proteins;Cell Differentiation process;cell growth;Cell Proliferation;cell type;cellular retinoic acid binding protein II;Chronic;Clinical;clinical care;clinical translation;Clinical Treatment;Cues;Cytoplasm;Development;Devices;Diagnostic;Differentiation and Growth;Dimerization;disability;Disease;Drainage procedure;early detection biomarkers;effective therapy;Endothelial Cells;Etiology;Excision;experimental study;Exposure to;fatty acid-binding proteins;FGFR3 gene;FGFR4 gene;Fibroblast Growth Factor Receptors;Fibrosis;Functional disorder;functional restoration;Growth;Gynecologic;Hour;Hyaluronic Acid;Immune System Diseases;improved;In Vitro;in vivo;Individual;Infection;inhibitor;Injury;Intercellular Fluid;KDR gene;Laboratories;Limb structure;Liquid substance;Lymph Node Dissections;lymph nodes;Lymphangiogenesis;Lymphatic;lymphatic circulation;lymphatic drainage;Lymphatic Endothelial Cells;lymphatic insufficiency;Lymphatic Obstruction;lymphatic vessel;Lymphedema;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Melanoma;migration;minimally invasive;Molecular;Natural regeneration;Needles;Nuclear Receptors;Operative Surgical Procedures;Pathway interactions;Patients;Pelvic Cancer;pharmacologic;Pharmacotherapy;Plastic Surgeon;PPAR gamma;pre-clinical;Pre-Clinical Model;predictive modeling;prevent;Preventive treatment;promoter;Quality of life;receptor;Receptor Protein-Tyrosine Kinases;Recurrence;recurrent infection;regeneration following injury;response;retinoic acid receptor alpha;Risk;Rodent Model;Role;RXR;Sampling;Sarcoma;secondary lymphedema;selective expression;Sensitivity and Specificity;side effect;Signal Transduction;Skin;small molecule inhibitor;soft tissue;Solid Neoplasm;Spectrum Analysis;Surgical Injuries;Swelling;System;Techniques;Technology;Testing;Therapeutic;Tissues;translational framework;Treatment Protocols;Tretinoin;urologic;Vascular Endothelial Growth Factor C;Vascular Endothelial Growth Factor Receptor-3;Vitamin A;Work

PROJECT_TITLE: Retinoic Acid Induced Lymphangiogenesis for Post-Surgical Lymphedema

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


ORG_DEPT: UROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Deleterious mutations of DNA damage repair (DDR) genes associated with increased prostate cancer risk and mortality. However, our knowledge of the complete implications of DDR aberrations other than BRCA2 in prostate cancer tissue is limited due to functional significance gaps. This proposal introduces a novel approach to uncover the critical role of non-BRCA2 DDR gene alterations in prostate cancer biology, aiming to enhance treatment strategies.

PI_NAMEs: CHAKRABORTY, GOUTAM  (contact);PILLARSETTY, NAGAVARAKISHORE ;PONOMAREV, VLADIMIR

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;androgen independent prostate cancer;Androgen Receptor;Androgens;anti-cancer research;Biological Assay;Biological Models;BRCA2 gene;Cancer Biology;Cancer Patient;career development;Castration;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Combined Modality Therapy;Dideoxy Chain Termination DNA Sequencing;Disease;DNA Damage;DNA Repair;DNA Sequence Alteration;enzalutamide;Experimental Models;functional genomics;Gene Mutation;gene repair;Genes;Genome Stability;histone demethylase;Immunotherapy;Impairment;Individual;inhibitor;innovation;Knock-out;Knowledge;loss of function;Malignant neoplasm of prostate;Mediating;Mentorship;Modeling;Molecular;Molecular Biology;mortality;new therapeutic target;novel;novel strategies;novel therapeutics;Organoids;parent grant;Pathway interactions;Prostate;prostate cancer progression;prostate cancer risk;Prostatic Neoplasms;protective effect;Radiation therapy;Receptor-Interacting Protein;replication stress;Reporting;Research;Resistance;Resources;Risk;Role;sensor;Signal Pathway;Signal Transduction;Therapeutic;therapeutic development;Tissues;Training;transcriptomics;treatment strategy;tumor growth;Y Chromosome

PROJECT_TITLE: Functional Characterization and Development of Therapeutic Paradigms for DNA Damage Repair (DDR)-deficient Lethal Prostate Cancer


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Infant Mortality;Neurosciences;Pediatric;Prevention;Rare Diseases;Spina Bifida

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: PROJECT NARRATIVE This project employs innovative single-cell transcriptomics, conditional gene-targeting, genetic rescue, and maternal intervention approaches to systematically address the mechanisms of neural tube defects in mutant mouse models. It may provide a basis for future translational applications to prevent neural tube defects in humans.

PI_NAMEs: ZHOU, CHENGJI  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;Address;Affect;Agonist;Animal Model;Apical;Back;beta catenin;Bladder;Brain;Cell Polarity;Cells;Cessation of life;Child;Complex;Congenital Abnormality;constriction;convergent extension;Craniorachischises;Defect;design;Developmental Process;disability;Disease;Dorsal;early pregnancy;Ectoderm Cell;Exhibits;F-Actin;Face;Folic Acid;folic acid supplementation;Future;Gene Modified;gene regulatory network;Gene Targeting;Genes;Genetic;genetic risk factor;genetic testing;Goals;Human;Impairment;innovation;insight;Intervention;Intestines;Lifelong disability;Morbidity - disease rate;Mus;mutant;mutant mouse model;Mutant Strains Mice;Neonatal Mortality;Neural Fold;neural initiation;neural plate;Neural tube;Neural Tube Closure;Neural Tube Defects;Neuroectoderm;neuroepithelium;neuromechanism;Newborn Infant;novel;novel strategies;Paraplegia;Pathway interactions;pharmacologic;planar cell polarity;Play;Prevalence;prevent;Prevention;programs;Publishing;receptor;Research;Resistance;Risk;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Site;small molecule;Spinal;Spinal Cord;Spinal Dysraphism;Spinal meninges;Structure;Supplementation;Surface;Surface Ectoderm;Targeted Research;Testing;transcription factor;transcriptome sequencing;transcriptomics;Translating;translational applications;Vertebral column;WNT Family Gene;WNT Signaling Pathway;Work

PROJECT_TITLE: Integrated Wnt Signaling and Maternal Intervention of Neural Tube Defects

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-C(02)M]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Radiation Oncology

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Radiation therapy delivered at ultra-high radiation dose rates, which are more than 100 times faster than traditional radiation therapy delivery methods, has been postulated to produce a FLASH effect of similar tumor responses but with less toxicity to healthy tissue. However, not all preclinical studies testing ultra-high dose rates have reported consistent FLASH effects and no optimization has yet been performed to maximize the normal tissue sparing after FLASH compared to conventional irradiation. Therefore, the proposed study will analyze the FLASH effect using different types of radiation modalities, optimize parameters for delivery, and more precisely measure tumor curability, enabling consistent translation of this method of radiation therapy delivery to the clinic.

PI_NAMEs: SCHUELER, EMIL  (contact)

PROGRAM_OFFICER_NAME: BUCHSBAUM, JEFFREY

PROJECT_TERMS: Abdomen;Aftercare;Biological Assay;Body System;Brain;Cancer cell line;Cancer Patient;Clinic;conventional dosing;Dose;Dose Rate;Electrons;expectation;Fractionation;Gastrointestinal tract structure;Goals;Health;improved;Individual;Institution;irradiation;Lung;Malignant Neoplasms;Measurement;Measures;Mediating;Methods;Mission;Modality;National Cancer Institute;Normal tissue morphology;Oxygen;Photons;Physiologic pulse;pre-clinical;preclinical study;prevent;Quality of life;Radiation;Radiation Dose Unit;radiation effect;Radiation therapy;Reporting;Reproducibility;Research;response;side effect;Skin;stem;Testing;Therapeutic Effect;Time;Tissues;Toxic effect;Translations;tumor;tumor growth

PROJECT_TITLE: Research Supplements to Promote Diversity in Health-Related Research: Preclinical optimization of ultra-high dose rate (FLASH) radiotherapy parameters for translational relevance

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Cancer

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

ORG_STATE: WA

PHR: Project Narrative Per the NCI Diversity Supplement Guidelines, this section is not required. The research supplement proposal does not change the activities of the Parent Award.

PI_NAMEs: HOLLAND, ERIC C. (contact)

PROGRAM_OFFICER_NAME: MILLER, DAVID J

PROJECT_TERMS: Alternative Splicing;Gene Fusion;Guidelines;Malignant Neoplasms;parent project;Research;Role;Variant

PROJECT_TITLE: The role and mechanism of alternative RNA splice variants and gene fusions as drivers of cancer


ADMINISTERING_IC: FD

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR

PHR: PROJECT NARRATIVE The objectives of this proposal are to 1) determine the drug-related factors, 2) determine formulation-related factors and 3) determine the manufacturing methods and process-related factors of alcohol-induced dose dumping using carbamazepine and diltiazem hydrochloride as model drugs for extended release dosage forms. Various extended formulation designs will be developed using variety of extended release polymers and manufacturing methods (Design: matrix system, coating design; Manufacturing method: direct and wet granulation, coating, hot-melt, 3D printing) and evaluated for quality attributes and alcohol-induced dose dumping.

PI_NAMEs: KHAN, MANSOOR A (contact);RAHMAN, ZIYAUR

PROGRAM_OFFICER_NAME: AL-GHABEISH, MANAR

PROJECT_TITLE: Factors related to drug and Formulation affecting alcohol dose dumping in modified release oral drug products

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (07)]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Primary Health Care;Social Determinants of Health

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE The primary objective of this application is to promote researchers with diverse backgrounds, like Dr. Ewing, in the field of cancer health disparities and cancer control. The purpose of this study is to investigate the impact of health-related social needs on follow-up colonoscopy receipt among patients with abnormal stool-based test results. The results from this study will inform interventions that improve colorectal cancer screening completion rates in low-resourced settings.

PI_NAMEs: CORLEY, DOUGLAS ALLEN;DOUBENI, CHYKE ABADAMA (contact)

PROGRAM_OFFICER_NAME: MARCUS, PAMELA M

PROJECT_TERMS: Academy;Address;Adherence;American;Attention;cancer care;Cancer Control;Cancer Etiology;cancer health disparity;cancer type;Cessation of life;colon cancer patients;Colonoscopy;Colorectal Cancer;colorectal cancer screening;colorectal cancer treatment;Data;Disparity;Disparity population;Equity;experience;Face;Family Physicians;Feces;Federally Qualified Health Center;follow-up;Funding;Goals;Grant;Health;housing instability;improved;Incidence;insight;interest;Intervention;lens;Literature;Medical center;member;men;Mentors;mortality;Ohio;Outcome;outreach;parent grant;patient oriented;Patients;Play;Population;Recommendation;Research;Research Personnel;Resource-limited setting;Role;safety net;screening;screening guidelines;Services;social;social determinants;social health determinants;Statistical Data Interpretation;Test Result;therapy development;timeline;Transportation;Underserved Population;United States Preventative Services Task Force;Universities;Vulnerable Populations;Woman;Work

PROJECT_TITLE: Advancing Equity in Cancer Care: Investigating Health- Related Social Needs and Colonoscopy Follow-Up Among FQHC Patients

STUDY_SECTION: CHD

STUDY_SECTION_NAME: Cancer and Hematologic Disorders Study Section[CHD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Clinical Research;Electronic Nicotine Delivery Systems;Heart Disease;Heart Disease - Coronary Heart Disease;Nutrition;Prevention;Tobacco

PHR: NARRATIVE The metabolic syndrome affects a quarter of the global adult population and a third of US adults. Exposure to environmental pollutants including metals and metalloids may play a role in the development of metabolic outcomes and may mediate metal-related atherosclerosis and cardiovascular risk. This study will evaluate the role of metals in metabolic outcomes and the role of metabolic outcomes to influence metal-related CV risk, as measured in diverse young adults from New York City (Vape Scan Study).

PI_NAMEs: NAVAS-ACIEN, ANA  (contact);SHIMBO, DAICHI

PROGRAM_OFFICER_NAME: JOUBERT, BONNIE

PROJECT_TERMS: Acceleration;Adult;Affect;Age;Age Years;Arsenic;Atherosclerosis;atherosclerosis risk;Biological Markers;Blood;Blood Glucose;Blood Pressure;Cadmium;Cardiac;cardiometabolic risk;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cholesterol;cohort;coronary artery calcification;Coronary heart disease;Data;Development;Diabetes Mellitus;Disease;Early Intervention;Electronic cigarette;electronic cigarette use;electronic cigarette user;Environmental Epidemiology;Environmental Health;Environmental Pollutants;Ethnic Origin;Exposure to;Fasting;former smoker;Glucose;Heart;Hyperlipidemia;Hypertension;Individual;Knowledge;Lead;Lipids;Long-Term Effects;Longitudinal Studies;Manganese;Measures;Mediating;Mediation;Mediator;men;Metabolic;Metabolic Marker;metabolic profile;Metabolic syndrome;Metal exposure;Metals;Modeling;Molecular Epidemiology;Multi-Ethnic Study of Atherosclerosis;New York City;novel;older adult;Outcome;Outcome Measure;parent grant;Parents;Participant;Pathway interactions;Population;prevent;preventive intervention;primary outcome;Process;Prospective, cohort study;Race;racial diversity;recruit;Research;Risk;Risk Factors;Role;Scanning;Selenium;sex;skills;Smoker;Stroke;Students;System;Time;tobacco smokers;toxic metal;Training;Triglycerides;Universities;Urine;vaping;Visit;Woman;X-Ray Computed Tomography;young adult;Youth;Zinc

PROJECT_TITLE: Metal Exposure and Early Cardiovascular Risk in Adult E-Cigarette Users

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Lung Cancer;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PHR: Project Narrative The outcomes of minoritized patients with advanced cancer remain poor despite many attempts at improving equity. This proposal will employ a tool based on community input and co-developing suitable criteria for scoring the quality and content around clinical trial discussions. Recognizing the impact of effective communication on overall health, healthcare literacy, treatment adherence, trust-building, and reducing disparities, the study seeks to provide clinicians with tools to facilitate discussions with minorities about cancer clinical trials, addressing a critical need in the current landscape of cancer care.

PI_NAMEs: SMITH, CARDINALE B (contact)

PROGRAM_OFFICER_NAME: WEAVER, SALLIE JAYNE

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advocate;African American population;American Cancer Society;Black Populations;burden of illness;cancer care;cancer clinical trial;cancer health disparity;Cancer Patient;cancer therapy;career development;Caregivers;catalyst;Clinical Trials;Code;Communication;Communities;COVID-19 pandemic;Data;Death Rate;Dedications;Diagnosis;Disparity;disparity reduction;Early Diagnosis;Effectiveness of Interventions;Eligibility Determination;Enrollment;Equity;ethnic minority;Ethnic Origin;Ethnic Population;experience;Frequencies;Geography;Goals;Grant;Health;Healthcare;Hispanic Populations;implicit bias;improved;Insurance;Intervention;literacy;Malignant Neoplasms;meetings;Mentorship;Methods;Minority;Minority Groups;Minority Participation;minority patient;Not Hispanic or Latino;Oncologist;Outcome;outcome disparities;patient-clinician communication;Patient-Focused Outcomes;Patients;Prevalence;Provider;Race;racial minority;racial population;Research Personnel;Role;screening;smoking cessation;Solid;Survival Rate;Testing;Time;tool;Training;treatment adherence;Trust;United States National Institutes of Health;Withholding Treatment

PROJECT_TITLE: The Role of Implicit Bias on Outcomes of Patients with Advanced Solid Cancers


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE  Hundreds of thousands of genetic variations associated with complex diseases and traits have been uncovered within the past two decades, but remarkable gap persists between these discoveries and what is required to advance the clinical treatments and medicine. This application proposes to develop novel statistical methods to address computational and analytical challenges for combining high-dimensional molecular and cellular datasets for disease gene discovery. The methods and resources developed in this study will bridge the gap from genetic variations associated with disease risks to relevant biological processes and provide starting points for experimentalists and clinicians to translate the genetic findings into new preventative and therapeutic strategies.

PI_NAMEs: ZHOU, WEI  (contact)

PROGRAM_OFFICER_NAME: CHADWICK, LISA

PROJECT_TERMS: Address;Age related macular degeneration;Award;biobank;Biological;Biological Process;Calibration;cell type;Cells;Characteristics;Chromosome Mapping;Clinical Medicine;Clinical Treatment;cohort;Complex;Consensus;Coronary Arteriosclerosis;Data;Data Analyses;Data Set;data tools;design;Development;Disease;disorder risk;Distant;Educational process of instructing;Educational workshop;Ensure;Environment;Epigenetic Process;epigenomics;Etiology;experience;functional genomics;Future;gene discovery;Gene Expression;General Hospitals;Genes;Genetic;genetic analysis;genetic association;genetic variant;Genetic Variation;genome wide association study;genome-wide;genome-wide analysis;genomic variation;Genotype-Tissue Expression Project;Goals;Guidelines;Heritability;Heterogeneity;high dimensionality;human disease;improved;insight;large scale data;Leadership;Linkage Disequilibrium;Maps;Massachusetts;Measures;Medical;Mentors;Mentorship;Meta-Analysis;metabolomics;method development;Methodology;Methods;Modeling;Molecular;molecular phenotype;Multiomic Data;novel;open source;Participant;Pathway interactions;Phase;Phenotype;Proteomics;Quantitative Trait Loci;rare variant;repository;Research;Research Personnel;Research Training;Resolution;Resources;Running;Sampling;Schizophrenia;Scientist;Signal Transduction;single-cell RNA sequencing;skills;Statistical Methods;symposium;Technology;Testing;Therapeutic;Tissues;tool;Training;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translating;translational genetics;Translations;Untranslated RNA;Variant;Work

PROJECT_TITLE: An integrative approach to disease gene discovery combining genetic variation, gene expression, and epigenetics.

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: GAINESVILLE

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: PROJECT NARRATIVE Social stigma due to health conditions increases disease burden and adversely impacts health. The internalization of health-related stigma (i.e., self-stigma) is associated with impaired mental health and quality of life, yet little is known about how to reduce internalized stigma. The current project will test the effects of a novel, transdiagnostic, group counseling intervention, and of general peer support, to determine the optimal method for helping patients cope with health-related stigma, reducing its internalization, and, ultimately, enhancing patient quality of life.

PI_NAMEs: PEARL, REBECCA L (contact)

PROGRAM_OFFICER_NAME: TALKOVSKY, ALEXANDER MAXWELL

PROJECT_TERMS: Address;Adult;Affect;Behavior;burden of illness;chronic pain;Control Groups;coping;Counseling;Dehumanization;Diabetes Mellitus;Diagnostic;Discrimination;Disease;Disease Management;experience;Foundations;group counseling;Health;health care settings;health related quality of life;HIV;Impairment;improved;Individual;insight;internalized stigma;Intervention;Judgment;Latino;Malignant Neoplasms;maltreatment;marginalization;Measures;men;Mental Health;Methods;novel;Obesity;Participant;Patient Self-Report;Patients;peer support;physical conditioning;Physiological;Procedures;psychologic;Quality of life;Randomized, Controlled Trials;Reporting;Research;skin disorder;social stigma;Spanish;Stress;Support Groups;Testing;therapy design;therapy development;trait;Waiting Lists;Woman

PROJECT_TITLE: Assessing Internalized Health-Related Stigma in Spanish-Speaking Latino Adults


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Neurosciences;Patient Safety;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_DEPT: NEUROSURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Our team has developed an advanced, first-of-its-kind machine learning (ML) algorithm intended to provide prognostic information about severe brain tumors and advise decisions about neurosurgery. The capacity to obtain and make treatment decisions based on artificial intelligence-generated insights raises myriad ethical considerations and risk factors. This project will systematically collect original data via in-depth interviews with three relevant stakeholder groups (i.e., patients with brain tumors, caregivers of patients with brain tumors, neurosurgeons) to identify shared and unique needs, values, concerns, priorities, and perceived risks and benefits of using this technology both in research and clinical settings.

PI_NAMEs: LEUTHARDT, ERIC CLAUDE (contact);SHIMONY, JOSHUA S

PROGRAM_OFFICER_NAME: ZHANG, YANTIAN

PROJECT_TERMS: Academia;Accountability;Address;Adult Children;Algorithms;Artificial Intelligence;Benefits and Risks;Bioethics;Brain Mapping;Brain Neoplasms;brain surgery;Caregivers;Caring;Clinical;clinical practice;Clinical Trials;Communication;Conflict (Psychology);Data;Decision Making;Development;Diagnosis;Effectiveness;Equilibrium;Ethical Issues;Ethics;Excision;experience;Friends;Goals;Guidelines;Healthcare;Healthcare Systems;improved;Industry;Informed Consent;innovation;insight;interest;Interview;Judgment;Knowledge;Life;loved ones;Machine Learning;machine learning algorithm;machine learning prediction algorithm;Magnetic Resonance Imaging;Malignant Glioma;Malignant neoplasm of brain;neuroethics;Neuronavigation;Neurosurgeon;neurosurgery;neurotechnology;novel;Operative Surgical Procedures;Outcome;Patient-Focused Outcomes;Patients;Perception;Personal Satisfaction;prediction algorithm;Process;Prognosis;prognostic;prospective;Research;Research Personnel;responsible research conduct;Rest;Risk Factors;Role;Shapes;Spouses;stakeholder perspectives;Surgeon;Technology;technology development;technology validation;Time;treatment planning;uptake;Work

PROJECT_TITLE: Advancing Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(57)-R]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE: We will conduct a mixed-methods study, employing a national online survey and in-depth qualitative interviews, of public and key stakeholder perspectives on investigators’ responsibilities to research participants and non- participants in community-based pragmatic clinical trials (PCTs). We will then undertake a normative ethical analysis, informed by our empirical findings and a thematic synthesis of the relevant literature, to develop an ethical framework for community-based PCT protocol design. We will translate this framework into practicable directives for investigators and research oversight entities for the ethical conduct of community based-PCTs, specifically addressing NHLBI research priorities of confronting bioethical issues relevant to novel trial design and investigations involving vulnerable populations.

PI_NAMEs: NEWMAN, JONATHAN D (contact)

PROGRAM_OFFICER_NAME: BROWN, ALISON GWENDOLYN MARY

PROJECT_TERMS: Address;Administrative Supplement;Advocacy;air cleaner;air filtration;Attitude;Bioethical Issues;Bioethics;Bioethics Consultants;Blood Pressure;burden of illness;Cardiovascular Diseases;case-based;Categories;Characteristics;Clinical;clinical trial protocol;Clinical Trials Design;Communities;community engagement;Community Health;community organizations;community setting;Compensation;Conduct Clinical Trials;Data;design;Disease;Education;Environmental Risk Factor;Ethical Analysis;Ethical Directive;Ethics;Evaluation;Exclusion;experience;Exposure to;General Population;health care availability;Home;Human;Hypertension;inclusion criteria;Individual;Institutional Review Boards;Intervention;Interview;Investigation;Judgment;Knowledge;Literature;Measures;Medical;meetings;member;Methods;Moral Obligations;National Heart, Lung, and Blood Institute;New York City;novel;parent grant;Participant;participant enrollment;patient oriented;Population;portability;Positioning Attribute;Pragmatic clinical trial;Prevalence;Process;protocol development;Public Housing;Randomized;Randomized, Controlled Trials;recruit;Research;Research Design;Research Ethics;Research Personnel;Research Priority;Resources;response;screening;social;socioeconomics;stakeholder perspectives;Surveys;Translating;trial design;Vulnerable Populations;Work

PROJECT_TITLE: Researcher Responsibilities’ to Non-Participants in Community-based Pragmatic Clinical Trials

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Digestive Diseases;Pancreatic Cancer;Prevention;Rare Diseases

PHR: PROJECT NARRATIVE Pancreatic cancer is ranked as the fourth leading cause of cancer-related death in the United States with 1 - and 5-year survival rates of 20% and 7%, respectively. It is known that in pancreatic cancer zinc storage and transport is dysregulated, and that the level of dysregulation follows malignant progression. This work proposes a non-invasive technique to detect early malignant transformations in pancreatic cancer using a MRI zinc sensor. This approach based on MR imaging of zinc content and secretion places this proposal in a unique position to revolutionize the diagnostic paradigm of pancreatic cancer in the clinic.

PI_NAMEs: CLAVIJO JORDAN, MARIA VERONICA (contact)

PROGRAM_OFFICER_NAME: VAHEDI, SHAHROOZ

PROJECT_TERMS: Acinar Cell;Advisory Committees;Area;Biological;biomarker identification;biomarker validation;Biopsy Specimen;Caerulein;Cancer Etiology;Cells;Cessation of life;Characteristics;Chemicals;Clinic;Clinical Pathology;Curative Surgery;Data;Detection;Diagnosis;Diagnostic;Diagnostic Procedure;Disease;Ductal Epithelial Cell;Early Diagnosis;Early identification;effective therapy;Exocrine pancreas;Gadolinium;Goals;Grant;Histopathology;Homeostasis;Image;Imaging Techniques;in vivo;Knowledge;Lesion;Magnetic Resonance;Magnetic Resonance Imaging;Malignant - descriptor;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metals;Molecular;mouse model;Operative Surgical Procedures;pancreas development;pancreas imaging;Pancreatic Adenocarcinoma;Pancreatic Ductal Adenocarcinoma;Pancreatic Exocrine Secretion;Pancreatic Intraepithelial Neoplasia;Pathogenesis;Patients;Persons;Physiological;Positioning Attribute;premalignant;Probability;Radiology Specialty;Reporting;Research Activity;response;Role;sensor;skills;success;Survival Rate;Techniques;Tissues;Training;Training Activity;translational scientist;tumor;United States;United States National Institutes of Health;Work;Zinc;Zymogen Granules

PROJECT_TITLE: Imaging zinc secretion from the exocrine pancreas for the early diagnosis of pancreatic adenocarcinoma with MRI


ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE – Parent RO1 CA268055 Cisplatin-based combination chemotherapy is the standard-of-care treatment for muscle invasive bladder cancer but 70% of patients do not respond. We discovered a novel mechanism by which puromycin-sensitive aminopeptidase, NPEPPS, is upregulated, and we have strong evidence supporting its interaction with volume- regulated anion channels (VRACs) to block import of cisplatin and other platins into cancer cells. The focus of this proposal is to characterize this novel mechanism and evaluate pharmacological inhibition of NPEPPS in combination with platin drugs in preclinical models with the objective of eventually improving patient outcomes.

PI_NAMEs: COSTELLO, JAMES CHRISTOPHER;THEODORESCU, DAN  (contact)

PROGRAM_OFFICER_NAME: VENKATACHALAM, SUNDARESAN

PROJECT_TERMS: Adjuvant Chemotherapy;Affect;Afferent Neurons;Aminopeptidase;Animal Model;Anions;Antineoplastic Agents;Apoptosis;Binding;Bladder Neoplasm;Calcitonin Gene-Related Peptide;cancer cell;Candidate Disease Gene;Carboplatin;career development;Cell Death;Cell Line;Cell membrane;Cell Proliferation;cell type;Cells;chemotherapy;Chloride Ion;Chromatin;Cisplatin;Clinical;Combination Drug Therapy;Complex;CRISPR/Cas technology;Cystectomy;Cytarabine;Data;Daunorubicin;Dependence;Development;Disease;DNA Damage;druggable target;Dryness;Effectiveness;Feedback;Foundations;Genes;Goals;Growth;Human;improved;improved outcome;In Vitro;in vivo;inhibitor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Medical Research;Modeling;molecular modeling;muscle invasive bladder cancer;mutant;Neoadjuvant Therapy;Nerve Fibers;Neuromodulator;neuronal excitability;Neurons;neurotransmission;neurotransmitter release;Neurotransmitters;Nociception;Non-Malignant;novel;novel strategies;Organoids;Osmosis;Oxidative Stress;Pain;paracrine;Paracrine Communication;Parents;Patient-Focused Outcomes;Patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;Platinum;Positioning Attribute;pre-clinical;Pre-Clinical Model;Prognostic Marker;Proteins;puromycin-sensitive aminopeptidase;Radiation therapy;receptor;Reporting;Residual Neoplasm;Resistance;response;Role;Sensory;Shapes;Site-Directed Mutagenesis;standard of care;Taurine;Techniques;Testing;Training;transmission process;treatment response;tumor;tumor growth;Tumor Suppressor Proteins;tumorigenesis;whole genome

PROJECT_TITLE: Investigating NPEPPS-mediated feedback between bladder cancer cells and peripheral neurons as a mechanism of cisplatin resistance


ED_INST_TYPE: SCHOOLS OF PHARMACY

ORG_CITY: STORRS-MANSFIELD

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CONNECTICUT STORRS

PHR: Project Narrative: This proposal seeks to develop a physiologically based pharmacokinetic model to predict in vivo drug release from long acting injectable suspensions, through an in depth understanding of critical formulation attributes and critical process parameters. This will facilitate the development of bioequivalence recommendations for generic long-acting injectable suspensions. As a consequence of the proposed research, the regulatory burden will be reduced, and clinical studies will be minimized without sacrificing product quality and safety while delivering cost-effective products to the public with minimal delay.

PI_NAMEs: BURGESS, DIANE JANE (contact)

PROGRAM_OFFICER_NAME: ALAM, KHONDOKER

PROJECT_TITLE: Development of PBPK Model-Based Mechanistic IVIVCs for Long-Acting Injectable Suspensions

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CDER-T (03)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer

ORG_DEPT: BIOCHEMISTRY

PHR: PROJECT NARRATIVE Non-small cell lung cancer (NSCLC) is a leading cause of cancer death, but it lacks effective detection and treatment due to complicated pathogenesis mechanism. Our research aims to uncover how a crucial non- coding RNA is abnormal in its methylation in NSCLC and how this impacts the formation and phenotype of the cancer. This study will shed light on the pathological effects of de-regulated RNA modiﬁcation in NSCLC and establish a foundation for creating therapeutic molecular tools that can regulate gene expression through non- coding RNAs.

PI_NAMEs: XIE, MINGYI  (contact)

PROGRAM_OFFICER_NAME: MAAS, STEFAN

PROJECT_TERMS: A549;Accounting;Affect;Agar;Antibodies;Binding Proteins;Biological Assay;Biology;Cancer Biology;Cancer Cell Growth;Cancer cell line;Cancer Etiology;cancer gene expression;Cell Proliferation;Cells;Cellular Structures;Cessation of life;Chimeric Proteins;ChIP-seq;chromatin isolation by RNA purification sequencing;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;Data;Detection;detection assay;Development;effective therapy;Enzymes;Event;factor EF-P;Foundations;Future;Gene Expression;Gene Expression Regulation;gene regulatory network;Genes;Genetic Transcription;Goals;Growth;Heterogeneous-Nuclear Ribonucleoproteins;Human;Immunoprecipitation;knock-down;Label;lung cancer cell;Malignant neoplasm of lung;Malignant Neoplasms;malignant phenotype;Maps;Mediating;Methylation;migration;Migration Assay;Modification;Molecular;molecular subtypes;mouse model;negative elongation factor;Non-Small-Cell Lung Carcinoma;novel;Pathogenesis;Pathologic;Pathway interactions;Phenotype;Phosphorylation;Polymerase;Positive Transcriptional Elongation Factor B;programs;Proteins;Research;response;RNA;RNA methylation;RNA Polymerase II;Role;Site;small hairpin RNA;Small Nuclear RNA;Structure;Surveys;Therapeutic;Thiouridine;Time;tool;transcriptome sequencing;tumorigenesis;United States;Untranslated RNA;Work

PROJECT_TITLE: The molecular basis of 7SK RNA methylation in non-small cell lung cancer


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

ORG_CITY: SALT LAKE CITY

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Ceramides are products of fat and protein metabolism that accumulate in individuals with obesity or dyslipidemia and are strongly linked to insulin resistance. Herein we propose to leverage large-scale epidemiologic and clinical cohorts to identify associations of ceramides with colorectal cancer risk, and animal experiments to study the efficacy of new ceramide-lowering interventions. Our study will clarify the key role of ceramides in the metabolic dysregulation underlying colorectal cancer and identify new targets for colorectal cancer prevention. Project Narrative Page 7

PI_NAMEs: PLAYDON, MARY CHRISTINE (contact);SUMMERS, SCOTT A;ULRICH, CORNELIA M

PROGRAM_OFFICER_NAME: SIMONDS, NAOKO ISHIBE

PROJECT_TERMS: Address;Adipose tissue;Affect;Animal Experiments;Automobile Driving;Azoxymethane;bariatric surgery;Biological;Body Composition;Body Weight Changes;Cancer and Nutrition;cancer prevention;Ceramides;Clinical;cohort;Colorectal;Colorectal Cancer;colorectal cancer prevention;colorectal cancer risk;Colorectal Neoplasms;Complex;Data;desaturase;design;Development;dietary;Dietary Practices;dietary restriction;dihydroceramide desaturase;Dyslipidemias;efficacy study;Epidemiology;European;Fatty acid glycerol esters;Fatty Acids;Genes;Genetic;Goals;Incidence;Individual;inhibitor;Insulin Resistance;interdisciplinary collaboration;Intervention;Intestines;Investigation;Link;lipid metabolism;Lipids;Liver;Malignant neoplasm of lung;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;Medical;Metabolic;Metabolic dysfunction;Metabolism;mouse model;novel;nutrition;Nutritional;Obesity;Organ;pandemic disease;Participant;Pathogenicity;pharmacologic;preclinical study;prospective;protein metabolism;Public Health;response;Role;Serine;Serum;Signal Transduction;stem cell proliferation;Testing;Time;Tissues;translational approach;tumor metabolism;Utah

PROJECT_TITLE: Ceramides as novel drivers of metabolic dysfunction and colorectal cancer


NIH_SPENDING_CATS: Cardiovascular;Heart Disease

PHR: Project Narrative Atrial fibrillation (AF), the most frequent arrhythmia, is associated with the development of heart failure with preserved ejection fraction (HFpEF). Both AF and HFpEF are public health burdens. The proposed work will investigate whether the increased AF susceptibility can perpetuate the progression of HFpEF in animal models.

PI_NAMEs: LI, NA  (contact)

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acceleration;Animal Model;Arrhythmia;Atrial Fibrillation;Cardiac;coronary fibrosis;Development;EFRAC;Exhibits;FK506 binding protein 5;Heart Atrium;Heart failure;Insulin Resistance;Metabolic syndrome;Mus;Myopathy;Phosphorylation;Predisposition;preservation;Proteins;Proto-Oncogene Proteins c-akt;Public Health;Reporting;Role;Signal Transduction;Testing;Work

PROJECT_TITLE: FKBP5 AND CARDIAC ARRHYTHMOGENESIS


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

PHR: PROJECT NARRATIVE Our parent grant is focused on translational strategies to prevent pancreatic ductal adenocarcinoma (PDAC) by targeting the progression of intraductal papillary mucinous neoplasms (IPMN) using a micronutrient strategy. Emerging data suggests that the pancreatic tumor immune microenvironment (TIME) may influence IPMN progression. The major goal of this supplement is to improve the research training of a talented under- represented candidate through a research project which aims to elucidate the role of the TIME in IPMN progression in mice and humans.

PI_NAMEs: BATRA, SURINDER K.;MALAFA, MOKENGE P. (contact)

PROGRAM_OFFICER_NAME: UMAR, ASAD

PROJECT_TERMS: Address;Anxiety;Automobile Driving;Basic Science;carcinogenesis;Cells;Data;delta tocotrienol;Development;Disease;double-blind placebo controlled trial;Ductal Epithelial Cell;Evolution;Fright;functional status;Genetically Engineered Mouse;Goals;Health;High Prevalence;Human;Immune;immune function;Immunologics;improved;in silico;In Vitro;in vivo;insight;Intercept;Knowledge;Laboratories;Lesion;Magnetic Resonance Imaging;Malignant Neoplasms;Maps;Mediating;Micronutrients;mortality;Mucinous Neoplasm;Mus;novel;novel therapeutics;pancreas development;Pancreatic duct;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;Papillary;parent grant;Patients;Phase;Play;Population;predictive marker;prevent;prospective;Randomized;Research Project Grants;Research Training;Role;Sampling;Source;Talents;Testing;Therapeutic;Training;Translating;translational approach;Translational Research;tumor progression;tumor-immune system interactions

PROJECT_TITLE: Novel Therapy to Inhibit IPMN Progression

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Clinical Research;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

ORG_STATE: MD

PHR: No PHR

PI_NAMEs: MARTIN, STUART S (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Antibodies;Apoptosis;Behavior;Biological Assay;bone invasion;Bone Marrow;cancer stem cell;carcinogenesis;Cardiovascular system;Cells;Devices;Distant Metastasis;Drug Targeting;In Vitro;in vivo;Investigation;Lipids;Malignant Breast Neoplasm;Measures;Microtubules;migration;Modeling;mouse model;Neoplasm Metastasis;Phenotype;Proliferating;Relapse;response;Role;Signal Transduction;stem cell differentiation;Technology;Testing;triple-negative invasive breast carcinoma;Tubulin

PROJECT_TITLE: The investigation of tubulin microtentacle formation during resurgent breast cancer stem cell differentiation

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_CITY: AUSTIN

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: A PBPK model-based mechanistic IVIVCs will be built for PLGA-based long-acting solid implants. The use of PBPK modeling provides a unique opportunity to understand how the critical quality attributes of the implant affect in vivo release of implants. The modeling can also help define ‘safe space’ for critical formulation attributes, explain the source of PK variability, and extrapolate prediction to human subjects.

PI_NAMEs: HU, MING ;POLAK, SEBASTIAN ;ZHANG, FENG  (contact)

PROJECT_TITLE: Developing PBPK-model based mechanistic IVIVC for PLGA implants


NIH_SPENDING_CATS: Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Mental Health;Nutrition;Obesity;Physical Activity;Prevention;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health;Telehealth;Women's Health Research

PHR: PARENT PROJECT: PROJECT NARRATIVE Cancer is the leading cause of death among Latinos, and among Latinas, breast cancer is the leading cause of cancer death. Latinas are a population at high risk of obesity, diabetes, and other cardiometabolic comorbidities, which are associated with poorer breast cancer outcomes. We will test adaptive interventions to identify the most effective multi-component home-based, online, culturally-tailored weight loss adaptive intervention in Latina breast cancer survivors.

PI_NAMEs: GREENLEE, HEATHER  (contact)

PROGRAM_OFFICER_NAME: AGURS-COLLINS, TANYA

PROJECT_TERMS: Accelerometer;Active Learning;adaptive intervention;Address;Aftercare;Age;behavior change;Behavioral;Biological Markers;biopsychosocial;Blood;Body mass index;Body Weight decreased;Breast Cancer survivor;Cancer Etiology;Cancer Survivorship;cardiometabolism;Cause of Death;Cessation of life;Characteristics;comorbidity;compare effectiveness;Country;Data;Diabetes Mellitus;diabetes prevention program;Diagnosis;Diet;dietary;Dryness;Education;effective intervention;evidence base;exercise intervention;experience;Geographic Locations;Geography;Goals;Health;health care availability;health care service utilization;healthy weight;high risk;Home;Immigrant;inclusion criteria;Individual;Inflammatory;Intervention;Interview;Language;Latina;Latina Population;Latino Population;Length;Life;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediator;Medical History;Mental Health;novel;Obesity associated disease;obesity risk;Outcome;Outcome Study;parent project;Participant;Patients;Pattern;Personal Satisfaction;Physical activity;Population;programs;psychosocial;Psychosocial Factor;Quality of life;Questionnaires;Randomized;recruit;Recurrent disease;Registries;remote delivery;Reporting;residence;Sampling Studies;Sequential Multiple Assignment Randomized Trial;Social support;Spottings;Testing;trial design;weight loss intervention;weight loss program;Weights and Measures;Woman;Work

PROJECT_TITLE: Using a SMART design to evaluate remotely delivered, culturally tailored weight loss interventions among Latina breast cancer survivors

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


NIH_SPENDING_CATS: Biotechnology;Clinical Research;Genetics;Human Genome;Precision Medicine;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE  Multi-omic technologies enable high-throughput characterization of transcriptomic, metabolomic, lipidomic, epigenomic, and proteomic profiles, elucidating the complete chain of disease pathophysiology and offering the possibility of tremendous advances in our ability to diagnose, understand, and treat human disease. However, the ability of researchers, clinicians, and patients to reap the benefits of these investments in science and medicine will require the development of frameworks for clinical translation, including parameters for responsible return of individual research results from multi-omic data. The goal of this project is to create a preliminary map of the ethical, legal, scientific, and pragmatic challenges to return of multi-omic results with a focus on rare diseases, and to identify opportunities for the GREGoR Consortium to develop solutions to these challenges.

PI_NAMEs: MONTGOMERY, STEPHEN  (contact);WHEELER, MATTHEW THOMAS

PROJECT_TERMS: Address;Advocate;All of Us Research Program;Bioethics;Caring;Clinical;clinical practice;clinical translation;clinically actionable;Communities;Complex;Counseling;Data;Data Set;Databases;Development;Diagnosis;Diagnostic;Disease;disease diagnosis;Educational workshop;epigenomics;Equilibrium;Ethicists;Ethics;Functional disorder;Funding;Future;General Population;genetic counselor;Genetic Predisposition to Disease;Genomics;Goals;Guidelines;Health;human disease;Individual;individual patient;insight;Institutional Review Boards;Intention;Interview;Investments;Legal;lipidomics;Literature;Maps;Medicine;meetings;member;metabolomics;Mission;Molecular;Multiomic Data;multiple omics;National Human Genome Research Institute;Participant;Patients;Persons;Physical activity;Policies;programs;Proteomics;Rare Diseases;rare genetic disorder;recruit;Research;Research Personnel;Research Subjects;Resource-limited setting;Risk;Sampling;Science;Scientist;Site;Structure;Technology;transcriptomics;Transducers;Translating;Uncertainty;Veterans;volunteer;Work

PROJECT_TITLE: Stanford Mendelian Genomics Research Center


NIH_SPENDING_CATS: Coronaviruses;Data Science;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: LA JOLLA

ORG_NAME: LA JOLLA INSTITUTE FOR IMMUNOLOGY

PHR: Supplement Award PROJECT NARRATIVE The Immunophenotyping of a Coronavirus Cohort (IMPACC) study has generated unprecedented amounts of multi-omic systems biology data to define biomarkers of COVID severity and outcome. While most of the original funding supporting this effort has elapsed, it is recognized that there is a need for additional support for data and sample management including as needed to enable multiple high impact multi-omic IMPACC manuscripts currently in preparation. In this context, the Precision Vaccines Program (PVP) at Boston Children’s Hospital (BCH), operating via its Administrative Core and as the IMPACC Clinical Data Coordinating Center (CDCC), commits to providing additional comprehensive data coordination, quality control (QC), and quality assurance (QA), as well as robust digital infrastructure for the IMPACC project's data management and analysis needs. Parent Award PROJECT NARRATIVE Founded in 2010, the Human Immune Profiling Consortium (HIPC) has successfully brought together independent research centers to identify immune signatures associated with the outcomes of vaccinations and infections in humans. We propose to develop a HIPC Coordinating Center (HCC) that supports the HIPC network by providing a centralized Portal and Knowledgebase to facilitate data analysis and visualization, and to promote collaborations across the network by organizing subcommittees and cross-HIPC analysis projects.

PI_NAMEs: KLEINSTEIN, STEVEN H.;PETERS, BJOERN  (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Archives;Award;Biological Assay;Biological Markers;Boston;Budgets;centralized portal;Clinical;Clinical Data;clinical phenotype;Cloud Computing;Code;cohort;Cohort Studies;Collaborations;Communities;Computer software;Coronavirus;Coupled;COVID-19 severity;Data;Data Analyses;Data Coordinating Center;Data Files;data management;data portal;data quality;data quality/integrity;Data Set;data sharing;data standards;Data Storage and Retrieval;data submission;data visualization;database of Genotypes and Phenotypes;Databases;Dedications;Deposition;design;Development;digital;Ensure;experience;Familiarity;Funding;Funding Agency;Funding Opportunities;Grant;Human;Human Activities;Immune;Immune response;Immunology;Immunophenotyping;improved;Infection;Infrastructure;knowledgebase;Lead;Licensing;Maintenance;Manuscripts;Measures;meetings;multiple omics;Names;National Institute of Allergy and Infectious Disease;Outcome;Paper;parent project;Pediatric Hospitals;Preparation;Process;programs;promoter;Publications;quality assurance;Quality Control;repository;Research;Research Personnel;Resolution;Running;Sampling;Secure;Security;Serum;Site;System;Systems Biology;Time;tool;Update;vaccination outcome;Vaccines;virtual;Visualization;Work;working group;Writing

PROJECT_TITLE: HIPC Data Coordinating Center


ADMINISTERING_IC: DP

IC_NAME: NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION

ORG_CITY: Reston

ORG_NAME: ICF MACRO, INC.

PHR: PROJECT NARRATIVE The San Juan School District (SJSD) Wellness Demonstration Project seeks to align the SJSD’s school-based programming to Centers for Disease Control and Prevention’s (CDC’s) What Works in Schools (WWIS) approach; evaluate the SJSD Wellness Program that includes culturally responsive school-based strategies designed for American Indian/Alaska Native (AI/AN) youth; and identify, adapt, and pilot a tailored intervention for health education teachers. This project, guided by the Indigenous Evaluation Framework and the Knowledge to Action Framework for public health, will use community-based participatory research approaches for formative, process, and outcome evaluation and use culturally appropriate analytic methods to examine associated student-, teacher-, and environmental-level outcomes. We hypothesize that a purposeful and culturally grounded approach to program adaptation, implementation, and evaluation will yield significant contributions to strengthen the evidence base for CDC’s WWIS approach and build capacity for local education agencies to better serve AI/AN youth.

PI_NAMEs: MURRAY, COLLEEN CRITTENDEN (contact)

PROGRAM_OFFICER_NAME: SANDERS, CELESTE

PROJECT_TITLE: DP24-138 Demonstration Projects to Research and Evaluate Strategies Aligned with CDC's What Works in Schools Approach

STUDY_SECTION_NAME: Special Emphasis Panel[ZDP1 OHI (11)]


FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

NIH_SPENDING_CATS: Cancer;Clinical Research

ORG_CITY: FREDERICK

ORG_NAME: LEIDOS BIOMEDICAL RESEARCH, INC.

PI_NAMEs: QUINN, BROOKE  (contact)

PROJECT_TITLE: FY21 CONSOLIDATED FACILITIES TASK ORDER D- REFURBISHMENT AND INFRASTRUCTURE PROJECTS FOCUSED ON FACILITY IMPROVEMENTS WITHIN THE NCI AT FREDERICK CAMP


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Prevention;Women's Health Research

ORG_CITY: MORRISVILLE

ORG_NAME: HEALTH DECISIONS, INC.

ORG_STATE: NC

PI_NAMEs: DART, CLINT  (contact)

PROJECT_TERMS: Archives;Clinical;Clinical Trials;Clinical Trials Network;Consultations;Contraceptive Agents;Contraceptive methods;Data;Data Analyses;Data Collection;Development;Evaluation;Female Contraceptive Agents;Future;Guidelines;Male Contraceptive Agents;Manuscripts;men;Methods;Mission;Monitor;Monitoring Clinical Trials;National Institute of Child Health and Human Development;Program Development;programs;protocol development;Protocols documentation;Qualifying;Research;Services;Site;success;Woman

PROJECT_TITLE: STATUS DETERMINATION AND PRIORITIZATION OF PIPELINE PRODUCTS UNDERGOING CLINICAL TRIALS FOR MALE AND FEMALE CONTRACEPTION