NIH_SPENDING_CATS: Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: LEXINGTON

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: Patients with respiratory infections are frequently found to have more than one virus, but the impact of viral co-infection remains poorly understood. This work will examine the interactions between respiratory syncytial virus and human metapneumovirus during infection of the same cell, particularly focusing on key steps in the viral life cycle. These studies will provide molecular insights that will also inform examination of other respiratory virus co-infection, and may lead to novel therapeutic targets and treatment options.

PI_NAMEs: DUTCH, REBECCA E. (contact)

PROGRAM_OFFICER_NAME: KIM, SONNIE

PROJECT_TERMS: Affect;Area;Binding;Body Size;Cells;Clinical;co-infection;Complex;Disease;Event;experimental study;Filament;Fluorescent in Situ Hybridization;Foundations;genetic element;Genetic Materials;Genetic Transcription;Genome;Genomics;Glycoproteins;Human;Human Metapneumovirus;Hybrids;Immunocompromised Host;Inclusion Bodies;Individual;Infection;Influenza;influenzavirus;Innate Immune Response;insight;joint formation;Joints;Life Cycle Stages;Location;mathematical model;Messenger RNA;Molecular;Morbidity - disease rate;mortality;Natural Immunity;neutralizing antibody;new therapeutic target;novel;older patient;Outcome;particle;pathogen;pathogenic virus;Pathway interactions;Patient-Focused Outcomes;Patients;pediatric patients;Phase;Physiological;Pneumovirus;Pneumovirus Infections;Proteins;Public Health;Reagent;receptor binding;Reporting;Research;Resources;respiratory examination;respiratory infection virus;Respiratory syncytial virus;Respiratory System;Respiratory Tract Infections;respiratory virus;Role;Severities;single cell technology;Site;superresolution microscopy;Symptoms;System;Techniques;Testing;Time;Viral;Viral Interference;viral RNA;Virion;Virus;Virus Diseases;Virus Replication;Work

PROJECT_TITLE: HMPV/RSV co-infection: effects on replication and viral spread

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMII-U(01)]


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Microbiome;Nutrition;Obesity;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: OKLAHOMA CITY

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MISCELLANEOUS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR

ORG_STATE: OK

PHR: Project Narrative  The NOURISH-OK Study will identify how food insecurity contributes to insulin resistance, an important surrogate marker of many co-morbidities in HIV disease, using an integrated framework to identify key leverage points for insulin resistance. Drawing from these pathways, this study will adapt and evaluate a community-driven, science-informed “food as medicine” intervention designed to lower insulin resistance through healthy food access, food utilization skills, and other self-care behaviors. Knowledge gained from this study can benefit those living with HIV through the prevention and more effective management of pre-diabetes, diabetes, obesity, and non-alcoholic fatty liver disease.

PI_NAMEs: WETHERILL, MARIANNA  (contact)

PROGRAM_OFFICER_NAME: RAJAPAKSE, NISHADI

PROJECT_TERMS: Address;adverse childhood events;Behavior;Behavioral;Biological;Body Composition;Categories;Chronic;Chronic stress;Collaborations;Communities;comorbidity;Control Groups;control trial;cooking;coping;cost;cost effective;cost effectiveness;Cross-Sectional Studies;Data;Data Analyses;design;Diabetes Mellitus;Diet;dietary;dietary adherence;Dietary intake;dietary manipulation;Disease;Disparity;Eating;Educational Curriculum;Ensure;Equation;Evaluation;evidence base;Feedback;Fiber;Focus Groups;Food;Food Access;Food Assistance Programs;food insecurity;food security;Food Supply;General Population;Geography;group intervention;Guidelines;gut microbiome;gut microbiota;Health;Health Food;HIV;HIV Seropositivity;Home;Household;improved;indexing;Individual;Inflammation;Inflammatory;Influentials;Insulin Resistance;insulin sensitivity;Intake;Intervention;Interview;Investigation;Kidney Failure;Knowledge;Link;literacy;Liver diseases;Low Income Population;Measurement;Measures;Mediator;Medical;Medicine;Metabolic;microbiome;microbiome composition;microbiome signature;Minority;Mission;Modeling;modifiable risk;National Institute of Diabetes and Digestive and Kidney Diseases;non-alcoholic fatty liver disease;Nutrient;nutrition;Nutritional;Nutritional status;Obesity;Odds Ratio;Oklahoma;Outcome;Outcome Study;Pathway interactions;Patients;Persons;physical inactivity;pill;poor sleep;Prediabetes syndrome;Preparation;Prevention;Prevention approach;Provider;Psychological Stress;Randomized;Recipe;recruit;Reduce health disparities;Research;Research Design;Respondent;Risk;Risk Behaviors;Risk Factors;routine practice;Rural;Rural Community;Sampling;Sampling Studies;saturated fat;Science;secondary outcome;Secure;sedentary lifestyle;Self Care;Series;skills;Sleep;Sleep Deprivation;social;Source;Stratification;Study Subject;substance use;Surrogate Markers;Surveys;Testing;theories;therapy design;Tobacco use;Translations;trend;trial design;Underrepresented Populations;Urban Community;Urban Population;validation studies;Waiting Lists

PROJECT_TITLE: Nutrition to Optimize, Understand, and Restore Insulin Sensitivity in HIV for Oklahoma (NOURISH OK)


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: DALLAS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: PROJECT NARRATIVE Sepsis remains a significant cause of mortality among critically ill patients. Optimal metabolic and nutritional management for septic patients remains controversial. Understanding the mechanisms behind the protective response of anorexia and associated fasting metabolism to bacterial-induced inflammation will provide critical insights on how best to provide metabolic and nutritional support during sepsis.

PI_NAMEs: HUEN, SARAH  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Acute;Anorexia;Bacteremia;Body System;Brain;Cellular Stress;Complex;Critical Illness;Data;Endocrine;Fasting;Fibroblast Growth Factor;fibroblast growth factor 21;Genetic;Glucose;Goals;Heart;Hormones;improved;Inflammation;Innate Immune System;insight;ketogenesis;Ketones;Kidney;Knockout Mice;Laboratories;Lipids;Lipopolysaccharides;Liver;Mediating;Metabolic;Metabolic Pathway;Metabolic stress;Metabolism;Methods;mortality;mouse model;Nonesterified Fatty Acids;Nutritional;Nutritional Support;Organ;pathogen;Pathologic;Patients;pharmacologic;Physiology;PPAR alpha;Predisposition;Production;response;Sepsis;septic patients;Starvation;Supplementation;Tissue Model;Tissues

PROJECT_TITLE: Harnessing Fasting Metabolism to Improve Survival in Bacterial Sepsis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-T(55)R]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunotherapy

ORG_CITY: DUARTE

ORG_NAME: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE

ORG_STATE: CA

PHR: PROJECT NARRATIVE Regulatory T cells are vital for preventing overactivation of the immune system that may lead to autoimmune diseases. This proposal is expected to increase our understanding of the molecular mechanisms that control regulatory T cell development and function. This research is relevant to public health because it lays the groundwork for developing innovative therapeutic strategies against autoimmune disorders and cancer.

PI_NAMEs: BOLDIN, MARK P (contact)

PROGRAM_OFFICER_NAME: JIANG, CHAO

PROJECT_TERMS: Ablation;Affect;anti-tumor immune response;Antitumor Response;Autoimmune Diseases;Autoimmunity;cancer immunotherapy;Cancer Model;CD4 Positive T Lymphocytes;Cell Differentiation process;Cell Physiology;Cell Proliferation;Cell Therapy;Cells;Cellular biology;crosslink;Data;Defect;Development;Disease;Eragrostis;experimental study;Foundations;FOXP3 gene;Gene Expression;Gene Expression Profile;Generations;Genes;Genetic;genetic element;Genetic Epistasis;Germ Lines;Goals;High-Throughput Nucleotide Sequencing;Homeostasis;immune activation;Immune response;immune self tolerance;Immune system;Immune Tolerance;Immunity;Immunoprecipitation;Immunosuppression;Immunotherapy;Impairment;In Vitro;in vitro testing;in vivo;Individual;Infection;Infiltration;innovation;insight;Interferon Type II;knock-down;Knockout Mice;Knowledge;Link;loss of function;Lymphoproliferative Disorders;Malignant Neoplasms;Mediating;MicroRNAs;Molecular;Molecular Target;mouse model;Mus;novel;Pathway interactions;pharmacologic;Play;Post-Transcriptional Regulation;precursor cell;prevent;Process;Production;Proliferating;Public Health;Regulation;Regulatory T-Lymphocyte;Research;response;restraint;Role;role model;Route;Signal Transduction;small hairpin RNA;T-Cell Development;T-Lymphocyte;Testing;Therapeutic;Thymus Gland;transcriptome;tumor;tumor growth;Tumor Immunity;Up-Regulation;Work

PROJECT_TITLE: The role of miR-142 in regulatory T cell Development and function

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: SEATTLE

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Our Core Center for Clinical Research will further the development of scientifically rigorous, state-of-the-art methods for clinical musculoskeletal research; provide resources for conducting such research; and expand the community of investigators performing high-quality clinical research. This will increase the quality and quantity of data useful to clinicians, patients and policy makers as well as facilitate the transformation of traditional health care systems into learning health care systems. The ultimate goal is improvement of the quality of care and health of the public.

PI_NAMEs: JARVIK, JEFFREY G (contact)

PROGRAM_OFFICER_NAME: GREEN PARKER, MELISSA C

PROJECT_TERMS: Address;Advisory Committees;analysis pipeline;Archives;Artificial Intelligence;Biomedical Research;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;cohort;Collaborations;Communication;Communities;Comparative Effectiveness Research;Creativeness;Data;Data Analyses;Data Coordinating Center;data quality;Data Set;design;Development;Disease;effectiveness trial;Electronic Health Record;electronic health record system;Ensure;Environment;experience;faculty mentor;Fostering;Funding;Goals;Hand;health care delivery;Health system;Health Transition;Healthcare Systems;Image;image processing;imaging modality;Improve Access;improved;Informatics;innovation;Institution;interdisciplinary collaboration;interest;Knowledge;Leadership;Learning;learning strategy;Machine Learning;machine learning method;Measurement;Medical Imaging;Methodology;Methods;Modernization;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;next generation;novel;Observational Study;Occupational activity of managing finances;outreach;Patient Outcomes Assessments;Patients;Phenotype;Policy Maker;Population;Positioning Attribute;Pragmatic clinical trial;pragmatic study;Process;programs;Public Health;quality assurance;Quality of Care;Research;Research Activity;Research Design;Research Personnel;Research Training;Resources;Scientist;Services;statistical and machine learning;Structure;success;System;Text;tool;Training;Training Programs;United States Agency for Healthcare Research and Quality;United States National Institutes of Health;Universities;usability;Visit;Washington;Work

PROJECT_TITLE: UW Core Center for Clinical Research of Musculoskeletal Conditions


PROJECT_TERMS: Address;Advisory Committees;Area;Authorship;Budgets;Clinical;clinical center;Clinical Data;Clinical Research;Collaborations;Communication;Communities;Complex;cost;Data;Data Set;Electronic Mail;Ensure;Environment;Evaluation;experience;Faculty;faculty mentor;Feedback;Funding;Goals;Grant;Guidelines;Human Resources;Individual;Instruction;interest;International;Leadership;Learning;lectures;Manuscripts;meetings;Mentors;Methodology;Methods;Mission;Monitor;Musculoskeletal;Names;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Occupational activity of managing finances;outreach;Pacific Northwest;Patients;Personnel Management;Policy Maker;Program Reviews;programs;Publications;Publishing;Recommendation;Recovery;Research;Research Personnel;Research Project Grants;Research Training;Resources;Schedule;Scientist;senior faculty;Series;success;Training;Universities;Visit;Washington;webinar;Work

PROJECT_TITLE: Admin Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PI_NAMEs: HEAGERTY, PATRICK J (contact)

PROJECT_TERMS: Adopted;Algorithms;Area;Artificial Intelligence;Automobile Driving;Biomedical Research;Biometry;Characteristics;Clinical;clinical center;Clinical Data;clinical development;clinical predictors;Clinical Research;Clinical Services;Clinical Trials;Code;Collaborations;Collection;Communities;comparative effectiveness;convolutional neural network;Creativeness;Data;Data Collection;Data Coordinating Center;data quality;Data Science;data science infrastructure;design;Development;Diagnosis;Diagnostic;Disease;Electronic Health Record;electronic medical record system;electronic structure;Electronics;flexibility;Fostering;Foundations;Funding;Goals;health care delivery;Health Services Research;Health Technology;Heterogeneity;high dimensionality;image processing;Informatics;Information Retrieval;innovation;International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10);Leadership;Learning;Machine Learning;machine learning method;Measurement;Medical Imaging;Methodology;Methods;mHealth;Mission;Modernization;Monitor;Musculoskeletal;Musculoskeletal Diseases;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;Natural Language Processing;novel;observational cohort study;Observational Study;Organization administrative structures;Outcome;Patient Outcomes Assessments;Patients;Phase;Phenotype;Positioning Attribute;pragmatic study;pragmatic trial;Prevention;Procedures;Process;quality assurance;Radiology Specialty;Randomized;randomized trial;Reporting;Reproducibility;Research;research data dissemination;Research Design;Research Methodology;Role;Secure;statistical and machine learning;statistics;System;Telephone;Text;treatment effect;trial design;United States National Institutes of Health;Universities;unstructured data;Use Effectiveness;Validation;Washington;wearable device

PROJECT_TITLE: Methods Core


ADMINISTERING_IC: AG

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

ORG_CITY: LAS VEGAS

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: PROJECT NARRATIVE  Aging is a known risk factor for cancer and various diseases. It is widely accepted that the mechanical properties of aging tissues and cells are significantly different from young tissues, and altered tissue mechanics can contribute to cancer progression and development. In this study, I will test a hypothesis that aging skin tissue, exhibiting distinct mechanical/viscoelastic characteristics, promotes tumor progression of skin squamous carcinomas in elderly patients via p53- and ubiquitin pathways.

PI_NAMEs: PARK, SEUNGMAN  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: 3-Dimensional;Address;Adipocytes;Affect;Age;age effect;age group;age related;age related changes;Aging;aging related;Agreement;Binding;Biological Assay;Biological Markers;Biological Models;Biophysics;bioprinting;cancer cell;Cells;Characteristics;Chromatin;Coin;Collagen;Collagen Fiber;cost;crosslink;Custom;Dermis;Development;Devices;Disease;effective therapy;Elasticity;Epidermis;Etiology;Exhibits;Extracellular Matrix;Fibroblasts;Fluorescence Recovery After Photobleaching;Functional disorder;fundamental research;gain of function;Gene Expression;Genetic Transcription;Homeostasis;Human;human subject;Immunoprecipitation;In Situ;In Vitro;in vitro Model;in vivo;Incidence;keratinocyte;Kinetics;Knowledge;Lead;Link;Longitudinal Studies;Malignant Neoplasms;Mass Spectrum Analysis;MDM2 gene;Measurement;Measures;mechanical properties;mechanical signal;Mechanics;Mediating;mimetics;mimicry;Modeling;Modulus;Molecular;Motility;mutant;Mutation;older patient;Older Population;Pathology;Pathway interactions;Phenotype;Polymers;portability;Proliferating;Relaxation;Reporting;Research Design;Risk Factors;senescence;Skin;Skin Aging;Skin Cancer;Skin Tissue;Squamous cell carcinoma;Stress;Subcutaneous Tissue;Technology;Testing;three-dimensional modeling;Time;Tissues;tool;TP53 gene;Tumor Cell Invasion;tumor progression;Tumor Promotion;Ubiquitin;ubiquitin ligase;ubiquitin-protein ligase;viscoelasticity;Western Blotting

PROJECT_TITLE: Characterization of relation between tissue viscoelasticity and tumor progression in aging tissues

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Biological Aging Study Section[NIA-B]


NIH_SPENDING_CATS: Back Pain;Chronic Pain;Pain Research

PI_NAMEs: SURI, PRADEEP  (contact)

PROJECT_TERMS: Address;Aging;Area;Award;Back;Back Pain;biobank;Biometry;chronic pain;Clinical;clinical center;Clinical Data;Clinical Research;Clinical Trials;cohort;Cohort Studies;Communities;Conceptions;Data;data resource;Data Set;Databases;design;Diagnosis;disability;discogenic pain;Electronic Medical Records and Genomics Network;Ensure;Epidemiology;experience;fitness intervention;Flare;Funding;Future;Genomics;Goals;Grant;Hand;Image;image processing;Individual;Infrastructure;interest;Learning;Longitudinal cohort;Low Back Pain;Methodology;Methods;Mission;Musculoskeletal;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;novel;Operative Surgical Procedures;osteoporosis with pathological fracture;Outcomes Research;Pain;pain outcome;Pathway interactions;Patient Outcomes Assessments;Phase;programs;Publications;Randomized, Controlled Trials;Reporting;Research;Research Activity;Research Personnel;research study;Resources;Safety;Scientist;Services;skills;Specific qualifier value;Spinal Injections;Spinal Stenosis;Steroids;Study Skills;success;Testing;Time;tool;treatment effect;treatment trial;United States Centers for Medicare and Medicaid Services;Universities;validation studies;Visit;Washington;webinar;Work

PROJECT_TITLE: Resource Core


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Physical Activity

ORG_CITY: RICHMOND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: NARRATIVE Patients with paroxysmal atrial fibrillation (intermittently disordered contraction of the top chambers of the heart) may experience maladaptive changes within the left atrium as a result of repeated episodes of the arrhythmia, impairing overall cardiac performance during exercise and predisposing patients to the development of heart failure. Catheter ablation is an important treatment option that can significantly reduce or even eliminate episodes of atrial fibrillation, but the degree to which it might alter left atrial performance during exercise is largely unexplored. This longitudinal study will leverage the precision of exercise-based cardiovascular magnetic resonance imaging in patients with paroxysmal atrial fibrillation, examining the effects of catheter ablation on left atrial function during exercise, its relationship to left ventricular function during exercise, and its contribution to overall exercise capacity.

PI_NAMEs: TRANKLE, CORY  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Ablation;Activities of Daily Living;Affect;Arrhythmia;Atrial Fibrillation;Atrial Function;Bicycling;Cardiac;Cardiac ablation;cardiac magnetic resonance imaging;Cardiomyopathies;Cardiopulmonary;cardiovascular imaging;Cardiovascular system;career;Clinical Research;common treatment;Contracts;Data;design;Development;Diagnostic;Diastole;Disease;Echocardiography;Environment;Evaluation;Exercise;exercise capacity;exercise intolerance;Exercise Physiology;Exercise Test;Exertion;experience;Functional disorder;Future;Goals;Heart;Heart Atrium;Heart Diseases;Heart failure;heart function;Heart Rate;high risk;Impairment;improved;Incidence;Individual;innovation;Institution;interest;knowledge base;Lead;Learning;Left;Left Atrial Function;Left atrial structure;Left Ventricular Function;Literature;Longitudinal Studies;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Measures;Mechanics;Mentors;Methods;Modality;multidisciplinary;noninvasive diagnosis;Oxygen Consumption;patient oriented;Patients;Performance;Phenotype;Positioning Attribute;potential biomarker;Principal Investigator;programs;prospective;Publishing;Regulation;Research;Research Methodology;Research Personnel;Research Project Grants;Rest;Risk;Role;Sinus;statistics;Stroke Volume;Structure;Supination;targeted treatment;Techniques;Therapeutic Intervention;Training;training project;Ventricular;Writing

PROJECT_TITLE: EXercise Cardiac Magnetic Resonance Assessment of Left Atrial Mechanics Following Ablation TO Reduce Atrial Fibrillation Burden and Correlation with Exercise CapacitY: EXCLAMATORY Longitudinal Study

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Autoimmune Disease;Cannabinoid Research;Clinical Research;Digestive Diseases;Endocannabinoid System Research;Inflammatory Bowel Disease;Microbiome

ORG_CITY: WORCESTER

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: Project Narrative Ulcerative Colitis is a devastating life-long disease which poses a significant health and financial burden on patients and the healthcare system. This proposal aims to develop a group of microbes, which together dampen aberrant colonic inflammation and explore the specific signals and interactions of intestinal microbes that regulate intestinal neutrophil infiltration and thus inflammation. Upon completion of this project, we will better understand the specific pathways and interactions that maintain intestinal homeostasis, which can be leveraged to develop new bacteriotherapeutic approaches treat ulcerative colitis.

PI_NAMEs: SALLIS, BENJAMIN FIDELIUS (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: ABCB1 gene;Affect;Age;Antibiotics;Antibodies;Automobile Driving;Bacteria;Bacterial Infections;base;Biochemical Pathway;Colitis;Colon;Colonic inflammation;commensal bacteria;commensal microbes;Communication;cost effective;Data;Databases;Dependence;design;Development;Disease;disease model;Disease remission;dysbiosis;economic cost;Economics;Endocannabinoids;Enterocytes;Epithelial Cells;Epithelium;Equilibrium;experimental study;Feces;Financial Hardship;Functional disorder;Genes;gut inflammation;gut microbes;Health;Healthcare Systems;Human Microbiome;Immune;immune activation;Immune system;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Infusion procedures;inhibiting antibody;Injury;insight;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestines;Lead;Maintenance;mathematical model;Mediating;Metabolic;Metagenomics;Methods;Microbe;microbial;microbial community;microbiome;microbiota;microorganism interaction;migration;Modeling;Morbidity - disease rate;mortality;mouse model;Mucositis;Multi-Drug Resistance;Mus;neutrophil;Neutrophil Infiltration;novel;novel strategies;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Population;Predisposition;Prevalence;prevent;Publishing;Pump;Reaction;Recurrence;Regulation;Relapse;Research Priority;response;restraint;Risk;Risk Reduction;Severity of illness;sex;side effect;Signal Induction;Signal Transduction;Single Nucleotide Polymorphism;Spontaneous colitis;standard of care;Stratification;System;systemic inflammatory response;Testing;therapeutic target;Tissues;TNF gene;transcytosis;Treatment Failure;Ulcer;Ulcerative Colitis;Work;Xenograft Model

PROJECT_TITLE: Bacterial targeting of the P-glycoprotein/endocannabinoid axis for reducing intestinal inflammation in ulcerative colitis


ADMINISTERING_IC: MH

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Brain Disorders;Genetics;Mental Health;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: WILLISTON

ORG_NAME: MICROBRIGHTFIELD, LLC

ORG_STATE: VT

PHR: Narrative Performing comprehensive spatial distribution analysis of populations of messenger RNAs and proteins in neurons in tissue processed for expansion microscopy holds the promise of profound progress in next-generation basic and translational neuroscience studies such as investigating the effects of aging, understanding neurodevelopmental, neuropsychiatric, neurodegenerative and neurological disorders and diseases, and drug discovery. Our proposed product will be a transformative technology, using a number of technical innovations that, for the first time, will enable researchers to perform these data-rich studies without the need to have a computer scientist on staff to run the existing, lab-based software developed for this kind of complex analysis. This system will allow researchers to make new discoveries based on new studies that are currently not feasible, ultimately providing the basis for developing novel treatments to prevent and fight complex brain diseases.

PI_NAMEs: GLASER, JACOB R (contact)

PROGRAM_OFFICER_NAME: DURKIN, JACLYN MARIE

PROJECT_TERMS: 3-Dimensional;age effect;Aging;Antibodies;Axon;Benchmarking;Biological;Biological Preservation;Biological Sciences;Biotechnology;Brain;Brain Diseases;Cell Physiology;Central Nervous System;Classification;Collaborations;Communities;Complex;Complex Analysis;complex biological systems;computer scientist;Computer software;Data;Dendrites;Dendritic Spines;design;Detection;Development;Disease;Drug Addiction;drug development;drug discovery;Feasibility Studies;fighting;fluorophore;high dimensionality;Image;image registration;improved;In Situ;Individual;innovation;interest;Investigation;Knowledge;Label;Light;Manuals;Maps;Messenger RNA;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;Morphology;nanoscale;Nervous System Disorder;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal cell body;Neurons;neuropsychiatric disorder;Neurosciences Research;new technology;next generation;novel;Performance;Peripheral;pharmacologic;Phase;Population;Population Analysis;Population Distributions;Preparation;prevent;Process;Production;Proteins;Proteome;prototype;reconstruction;research and development;Research Personnel;research study;Resolution;Running;Sampling;Societies;software development;Spatial Distribution;Specimen;Stains;Structure;Subcellular structure;Synapses;System;Techniques;Technology;terabyte;Testing;Three-Dimensional Image;Time;Tissue Expansion;tissue processing;Tissues;transcriptome;translational neuroscience;Translations;treatment strategy;usability;Validation;Visualization;Work

PROJECT_TITLE: NeuroExM


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ORLANDO

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CENTRAL FLORIDA

ORG_STATE: FL

PHR: Pertussis toxin must enter a host cell in order to elicit an effect that contributes to whooping cough. This proposal will help define the cellular events and host proteins that facilitate the passage of pertussis toxin into the host cell. Disruption of this process would protect both the cell and the patient from the effects of pertussis toxin, so the knowledge gained from this proposal could be used to develop treatments for whooping cough.

PI_NAMEs: TETER, KENNETH R (contact)

PROGRAM_OFFICER_NAME: GU, XIN-XING

PROJECT_TERMS: Acceleration;ADP ribosylation;Affect;Affinity;Amino Acid Sequence;Binding;Binding Sites;Biological Assay;Catalytic Domain;Cell Culture Techniques;Cell membrane;Cells;Cholera Toxin;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Complex;Couples;Cyclophilin A;cyclophilin B;Cyclophilins;Cyclosporine;Cytosol;Degradation Pathway;Disease;Dissociation;Endocytosis;Endoplasmic Reticulum;Event;Extracellular Space;Face;Family;Family member;Goals;Heat-Shock Proteins 90;In Vitro;inhibitor;Intoxication;Isomerism;Isotopes;Knowledge;Lead;Length;Link;loss of function;Mediating;member;Membrane;Microsomes;Modeling;Molecular Chaperones;N-terminal;Nature;novel;p97 ATPase;Patients;Peptide Library;Peptidylprolyl Isomerase;Pertussis;Pertussis Toxin;pharmacologic;Pilot Projects;Point Mutation;prevent;Process;Proline;Protein Family;protein folding;Proteins;Reporting;retrograde transport;RNA Interference;Role;Side;Spectroscopy, Fourier Transform Infrared;Structure;therapeutically effective;Toxin;Travel;Work

PROJECT_TITLE: Proline residues are a key determinant for toxin entry into the host cytosol

STUDY_SECTION: BHI

STUDY_SECTION_NAME: Bacterial-Host Interactions Study Section [BHI]


NIH_SPENDING_CATS: Biomedical Imaging;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: CITY COLLEGE OF NEW YORK

ORG_STATE: NY

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it will accelerate the development of device-based interventions for neurological and psychiatric disorders associated with aberrant neural activity. Thus, the proposed research is relevant to the part of NIH's mission that pertains to the application of fundamental knowledge about the nature of living systems to reduce illness and disability.

PI_NAMEs: DMOCHOWSKI, JACEK  (contact)

PROGRAM_OFFICER_NAME: BASKIR, RUBIN SAM

PROJECT_TERMS: Acceleration;Acoustics;Address;Anesthesia procedures;awake;Brain;Brain region;cell type;Cells;Clinical Research;Communities;cranium;Data;Deep Brain Stimulation;density;Device or Instrument Development;disability;Dose;Electromagnetics;Electrophysiology (science);excitatory neuron;Exhibits;extracellular;Focused Ultrasound;Frequencies;Future;Goals;Head;hippocampal pyramidal neuron;Hippocampus;Image;inhibitory neuron;innovation;Interneurons;Intervention;Knowledge;Learning;Link;Mental disorders;millimeter;Mission;Modeling;Nature;Nervous System Disorder;neural;neural circuit;Neurobiology;Neurology;Neurons;neuroregulation;Neurosciences;noninvasive brain stimulation;novel;Operative Surgical Procedures;Organism;Outcome;outcome disparities;Penetration;Periodicity;Pilot Projects;Population;postsynaptic;preference;Psychiatry;Public Health;Pyramidal Cells;Rattus;Reporting;Research;Resolution;response;Role;Sleep;soft tissue;Source;Synapses;Synaptic Potentials;Techniques;Technology;Testing;Training;Ultrasonics;ultrasound;United States National Institutes of Health;Urethane;Work

PROJECT_TITLE: Explaining the variability in focused ultrasound neuromodulation


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Immunotherapy;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD);Orphan Drug;Precision Medicine;Rare Diseases

PHR: Project Narrative The use of small animal models and clinical trials using medical imaging have led to improved diagnosis and treatment of human disease. The goal of this work is develop methods and resources for co-clinical trials using PET imaging, and to implement them in a co-clinical trial evaluating immunotherapy treatment for lung cancer. The methods and resources developed to improve the utility of early-phase oncology trials using co-clinical studies with PET imaging will be distributed to accelerate the development of needed effective cancer therapies.

PI_NAMEs: HOUGHTON, A MCGARRY;KINAHAN, PAUL E. (contact)

PROGRAM_OFFICER_NAME: ZHANG, HUIMING

PROJECT_TERMS: Acceleration;animal imaging;Animal Model;antagonist;anti-PD-1;anti-PD-L1 therapy;Atypical lymphocyte;Calibration;Cancer Etiology;cancer imaging;Cancer Patient;cancer therapy;Cessation of life;checkpoint therapy;Clinical;clinical imaging;Clinical Research;Clinical Trials;co-clinical trial;data sharing;Development;Diagnosis;digital;Digital Imaging and Communications in Medicine;early detection biomarkers;Future;Genetically Engineered Mouse;Glean;Goals;human disease;IL8RB gene;Image;imaging informatics;imaging modality;Immune checkpoint inhibitor;Immunotherapy;improved;improved outcome;Industry Standard;Infiltration;Informatics;innovation;Link;Lung Adenocarcinoma;Malignant - descriptor;Malignant neoplasm of lung;Medical Imaging;member;Metadata;Methods;Modeling;monocyte;mouse model;Mus;neutrophil;Non-Small-Cell Lung Carcinoma;novel;Oncology;oncology trial;open data;open source;Outcome;PD-1/PD-L1;PET/CT scan;Phase;Positron-Emission Tomography;pre-clinical;preclinical imaging;preclinical study;programs;Protocols documentation;quantitative imaging;recruit;Resources;response;Site;Squamous Cell Lung Carcinoma;Structure;success;Testing;Therapeutic;tumor;tumor microenvironment;web-accessible;Work

PROJECT_TITLE: A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PUBLIC HEALTH STATEMENT The proposed research will examine whether a self-administered, web-based intervention designed to promote agency (in combination with or without teacher training to support motivation) can promote immediate and long-term motivation, engagement, achievement, and persistence in a large, diverse sample of college students enrolled in introductory classes required of biomedical science majors. This research has the potential to validate an intervention that could help to increase diversity in biomedical science and is a critical step toward creating a cost-and-time-efficient, scalable intervention to support student persistence in biomedical sciences.

PI_NAMEs: PATALL, ERIKA A. (contact)

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Achievement;active control;Address;Adopted;Advocate;Asian;Behavioral;Belief;Black race;career;Characteristics;Climate;college;cost;Education;educational atmosphere;Educational Intervention;Educational process of instructing;Effectiveness;effectiveness evaluation;empowerment;Enrollment;experience;experimental study;Female;Gender;Generations;Goals;Indigenous American;innovation;Institution;instructor;interest;Intervention;intervention effect;Intervention Studies;Investigation;Joints;Latinx;Long-Term Effects;male;Mental Health;Motivation;Outcome;Outcome Measure;Pacific Islander;Personality;Privatization;Process;programs;psychologic;Public Health;Race;Randomized;Reporting;Research;Sampling;Schools;Science;science education;Self Administration;Self Efficacy;Social Identification;Social Values;student participation;Student Persistence;student training;Students;Teacher Professional Development;Testing;therapy design;Time;undergraduate student;Underrepresented Minority;underrepresented minority student;Universities;university student;web-based intervention;Work

PROJECT_TITLE: Supporting Student Agency in Undergraduate Biomedical Education


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Narrative For the brain to function it is essential that large numbers of neurons are interconnected in a highly precise manner, a process which is controlled by the patterns of genes expressed during brain development. Work of this grant focuses on a circuit of the Drosophila brain controlling navigation. We are analyzing connectivity within this circuit with digital connectomes, and use optogenetic tools to record and manipulate neuronal activity in order to develop concepts which are important to understand, and therapeutically manipulate, circuits formed by nerve cells in the human brain.

PI_NAMEs: HARTENSTEIN, VOLKER  (contact);LOUIS, MATTHIEU R. P. J. C. G.

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TITLE: Developmental and functional analysis of neural circuits controlling navigation in Drosophila

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Bilinguals showed remarkable language control abilities in both production and comprehension, but it remains unclear if and to what extent control mechanisms are shared or different across these modalities. The proposed project will adopt ERP measures to conduct a thorough and systematic comparison between them, and it will investigate how syntactic and phonological constraints influence in-context language control in the two modalities. This project will lead to a comprehensive understanding of language control, lay the groundwork to develop theory-driven approaches of the assessment of language and cognitive abilities in bilinguals, and may ultimately foster communication and language learning in an increasingly multilingual society.

PI_NAMEs: LI, CHUCHU  (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TITLE: ERPs reveal the Mechanisms of Bilingual Language Control

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Microbiome;Nutrition;Pediatric

ORG_CITY: Rockville

ORG_NAME: RISE THERAPEUTICS, LLC

ORG_STATE: MD

PHR: Project Narrative Type 1 Diabetes (T1D) is an autoimmune disease caused by autoreactive T-cell-mediated destruction of islet β cells. This project stems from our recent positive Phase 1 clinical trial results in which R-5280, a modified superior resistant starch, significantly mitigated T1D severity in adolescents. Here, we propose to perform a confirmatory Phase 2 clinical trial to corroborate R-5280 efficacy and safety. Successful commercialization would ultimately provide a profound front-line medical advancement for the treatment of T1D.

PI_NAMEs: FANGER, GARY ;FURLAN FREGUIA, CHRISTIAN  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: 16 year old;Acetylation;Adolescent;Affect;Age;American;Amylose;Attention;Autoimmune Diseases;autoreactive T cell;Beta Cell;Biological Markers;Biological Products;Biological Response Modifier Therapy;biomarker discovery;Blinded;Body mass index;Chronic;Circulation;Clinical;Clinical Research;clinical trial enrollment;commercialization;Consumption;Continuous Glucose Monitor;cost;curative treatments;diabetes management;Diabetes Mellitus;Diagnosis;dietary;Dietary Fiber;Disease;Double-Blind Method;Drug usage;early onset;Enrollment;Environment;Esterification;fecal microbiome;Feces;Fermentation;Genetic;glycemic control;Goals;gut microbiome;gut microbiota;Health;Human;Human Resources;Immune;Immune response;Immunity;Immunologics;immunomodulatory therapies;Immunophenotyping;improved;Incidence;Indiana;Inflammatory;Injectable;Insulin;insulin dependent diabetes mellitus onset;insulin secretion;insulin sensitivity;Insulin-Dependent Diabetes Mellitus;Intestines;islet;Label;Leaky Gut;Life;Long-Term Effects;manufacture;Mediating;Medical;metabolome;metabolomics;microbiome;microbiome therapeutics;novel;novel strategies;Oral;Oral Administration;participant enrollment;patient population;Patients;Persons;Pharmaceutical Preparations;Pharmacodynamics;Pharmacy facility;phase 1 study;Phase I Clinical Trials;phase I trial;Phase II Clinical Trials;phase II trial;Placebo Control;Placebos;Prevalence;Probiotics;Process;Production;Property;Protocols documentation;Quality of life;Randomized;randomized placebo controlled trial;Residual state;Resistance;response biomarker;Risk;Safety;Severities;sex;side effect;Social Interaction;Source;Specific qualifier value;Specimen;Starch;stem;Structure of beta Cell of islet;success;T-Lymphocyte;Testing;Therapeutic;Time;Training;treatment duration;Universities;Volatile Fatty Acids;Well in self

PROJECT_TITLE: R-5280, A Novel Modified Superior Resistant Starch Therapy for Type 1 Diabetes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-EMS-K(10)B]


NIH_SPENDING_CATS: Biotechnology;Cancer;Immunotherapy

ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE This study addresses how a chaperone molecule called GRP94 controls cancer and determines the best strategy to target GRP94 for cancer immunotherapy. Significant discoveries have been made regarding the roles of GRP94 in controlling the pathway of transforming growth factor beta (TGFb). Several therapeutic leads have emerged in blocking the GRP94-TGFb pathway; further in-depth study of GRP94 will advance novel therapies for cancer.

PI_NAMEs: LI, ZIHAI  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: Address;anti-cancer;Antibodies;Area;B-Lymphocytes;Binding;Biochemical;Biogenesis;Biology;Blood Platelets;Cancer Biology;cancer cell;Cancer Control;cancer immunotherapeutics;cancer immunotherapy;cancer therapy;cell growth;Cell surface;cell type;chimeric antigen receptor;Client;Clinical;Clinical Trials;Collaborations;Complex;convict;Degradation Pathway;design;Development;Docking;effector T cell;Endoplasmic Reticulum;engineered T cells;Eragrostis;Foundations;genetic approach;Goals;Growth Factor Receptors;GRP94;Heat-Shock Proteins 90;Human;Immune;immune checkpoint;Immune checkpoint inhibitor;immune resistance;Immune Tolerance;Immunity;Immunologics;Immunotherapeutic agent;Immunotherapy;inhibitor;insight;Insulin-Like Growth Factor I;Insulin-Like Growth Factor II;Integrins;Laboratories;leucine-rich repeat protein;LRRC32 gene;Malignant Neoplasms;Manuscripts;Mediating;Membrane Glycoproteins;migration;Molecular;Molecular Chaperones;Myelogenous;Nature;new therapeutic target;next generation;novel;novel therapeutics;Oncogenic;overexpression;paralogous gene;Pathway interactions;PD-1/PD-L1;Pharmaceutical Preparations;Phase;Play;pre-clinical;Pre-Clinical Model;preclinical study;protein degradation;Proteins;Publishing;Quality Control;receptor;Regulation;Regulatory T-Lymphocyte;Renaissance;Resistance;response;Role;side effect;Signal Pathway;Signal Transduction;Structural Biologist;Suppressor-Effector T-Lymphocytes;Surface;T cell therapy;T-Lymphocyte;targeted treatment;Therapeutic;Thrombin;Transforming Growth Factor beta;Translational Research;Tumor Escape;tumor microenvironment;tumorigenesis;VWF gene

PROJECT_TITLE: Targeting GRP94-TGF-beta Pathway for Cancer Immunotherapy

STUDY_SECTION: CII

STUDY_SECTION_NAME: Cancer Immunopathology and Immunotherapy Study Section[CII]


NIH_SPENDING_CATS: Aging;Arthritis;Osteoarthritis

ORG_CITY: BOSTON

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative Osteoarthritis affects multiple tissues within a joint, causing severe inflammation and tissue degeneration, but current treatment options are inadequate in part due to rapid clearance of drugs injected into the joint and lack of tissue-targeted delivery. This project will modify a promising OA drug by making it positively charged, utilizing its interaction with negatively charged cartilage to enhance cartilage penetration and retention, thereby transforming cartilage from a barrier to drug entry into a drug depot that can enable sustained delivery to cartilage and neighboring joint tissues. The strategy developed through this work can enable clinical translation of a variety of osteoarthritis drugs that are currently limited due to a lack of effective delivery techniques.

PI_NAMEs: BAJPAYEE, AMBIKA GOEL (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Acceleration;Adverse effects;Affect;Affinity;Anabolism;anakinra;Arthritis;articular cartilage;Avidin;Binding;Biochemical;Biodistribution;Biological;biomechanical test;Biotinylation;bone;Bone callus;Bovine Cartilage;Cartilage;Cartilage Matrix;Catabolism;Cell Survival;Cells;cellular targeting;Charge;clinical effect;clinical translation;Clinical Trials;Coculture Techniques;Collagen;Confocal Microscopy;cytokine;Degenerative polyarthritis;density;design;Diameter;Disease;Dose;driving force;Drug Carriers;drug clearance;Drug Delivery Systems;Drug Modulation;Drug or chemical Tissue Distribution;effective therapy;Effectiveness;Electrostatics;Engineering;Equilibrium;exosome;extracellular;Fracture;Gene Expression;Genes;Glycoproteins;Glycosaminoglycans;Histology;Immunohistochemistry;In Vitro;in vivo;Inflammation;Inflammatory;inhibitor;Injury;Interleukin-1;Interleukins;Intervertebral disc structure;Intra-Articular Injections;joint injury;Joints;Label;Mass Spectrum Analysis;Measures;Mediating;Meniscus structure of joint;microCT;MicroRNAs;Modeling;Modification;Organ;Oryctolagus cuniculus;Outcome;Penetration;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;prevent;Property;protein expression;Proteins;Proteomics;Radiolabeled;Rattus;residence;response;Role;Site;Specificity;Structure;subchondral bone;Synovial Fluid;Synovial joint;Synovial Membrane;Synovitis;systemic toxicity;targeted delivery;Techniques;Testing;Therapeutic;Thick;Time;time use;tissue degeneration;Tissues;Traumatic Arthropathy;uptake;Western Blotting;Work

PROJECT_TITLE: Intra-cartilage depot delivery of electrically-charged IL-1RA for targeting osteoarthritis-associated inflammation and catabolism in multiple joint tissues

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Drug Abuse (NIDA only);Fentanyl Misuse and Addiction;Neurosciences;Opioid Misuse and Addiction;Opioids;Prescription Drug Misuse;Substance Misuse

ORG_DEPT: ANESTHESIOLOGY

PHR: PROJECT NARRATIVE The widespread misuse of prescription opioids, addiction, and overdose have underscored the need to better understand how, where, and when opioid receptors’ action alters behavior in various brain regions. Here we will develop novel optopharmacological and precisionmethods for understanding how mu-opioids, like fentanyl, morphine, and others mediate effects in the brain to alter brain function, inhibit pain, and alter motivation. This understanding and these new tools will aid in developing safe and effective medications for pain and opioid addiction.

PI_NAMEs: BRUCHAS, MICHAEL R. (contact);GU, LIANGCAI

PROGRAM_OFFICER_NAME: BERTON, OLIVIER

PROJECT_TERMS: Absence of pain sensation;abuse liability;Acute;addiction;Address;Affect;Animals;Behavior;Biomedical Engineering;Biosensor;Brain;Brain region;calcium indicator;Cell membrane;Cells;Cessation of life;Characteristics;Chemicals;combinatorial;Coupled;design;Detection;Development;Devices;Dimerization;Drug abuse;Endoplasmic Reticulum;Ensure;experimental study;extracellular;Fentanyl;Fiber;Fluorescence;Golgi Apparatus;Head;illicit opioid;Image;Implant;In Vitro;in vivo;in vivo imaging;Infusion procedures;lens;Ligands;Link;Measures;Mediating;Methadone;Methods;Microdialysis;midbrain central gray substance;Monitor;Morphine;Motivation;multidisciplinary;Mus;Naloxone;nanobodies;National Institute of Drug Abuse;Needles;neural;neural circuit;Neurons;neurotransmission;NIH Program Announcements;novel;Nucleus Accumbens;Opiate Addiction;Opioid;Opioid Analgesics;Opioid Receptor;opioid use disorder;Optics;Oral;Overdose;Pathway interactions;Peptide Signal Sequences;Pharmaceutical Preparations;pharmacologic;Pharmacology;Photometry;prescription opioid abuse;prescription opioid misuse;Proteins;Reporter;Research;Resolution;response;Rewards;Saline;scaffold;Self Administration;sensor;Series;Signal Transduction;Site;spatiotemporal;System;temporal measurement;Testing;Therapeutic Uses;Time;tool;Training;two-photon;United States;Ventral Tegmental Area;Viral Vector;wireless

PROJECT_TITLE: Optopharmacology and Sensors for Dissecting Opioid Action In Vivo


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Immunotherapy;Organ Transplantation;Transplantation

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: Project Narrative This proposal follows up on our robust finding that valproic acid can upregulate Irg1, the tricarboxylic cycle enzyme producing itaconate, for cardioprotection of donor hearts for transplantation. We will determine how Irg1/itaconate mediates donor heart preservation by identifying the cell type where Irg1 is important, identify novel mechanisms by which itaconate modifies and regulates antioxidant proteins, and confirm its translational role in pig and human hearts. Results from this study will provide novel knowledge that can be directly applied to heart transplant patients to improve donor heart function and improve heart transplant outcomes.

PI_NAMEs: TANG, PAUL  (contact)

PROGRAM_OFFICER_NAME: SCHWARTZ, LISA

PROJECT_TERMS: Acetylation;Alkylation;Animals;anti-epileptic agents;Anti-Inflammatory Agents;Antioxidants;Biology;Cardiac;Cardiac Myocytes;Cardiac Output;cardioprotection;Cell Culture Techniques;cell type;Cells;Cessation of life;chromatin immunoprecipitation;Citric Acid Cycle;Clinical;Cre lox recombination system;Cre-LoxP;Cryopreservation;Cysteine;Data;Dependovirus;druggable target;efficacy evaluation;Endothelial Cells;Enhancers;Enzymes;Epilepsy;Erythroid;ex vivo perfusion;Exposure to;Family suidae;Future;Genes;Geography;Goals;graft dysfunction;HDAC4 gene;Heart;Heart failure;heart function;Heart Injuries;heart preservation;Heart Transplantation;heme oxygenase-1;Histidine;Histone Deacetylase Inhibitor;Histones;Hour;Human;Immune;Immune Targeting;immunodeficiency;immunoregulation;improved;Incidence;inducible Cre;Inflammation Mediators;Ischemia;Kidney;Kidney Failure;Knock-out;Knowledge;Liver;liver injury;Mediating;Medical;Medical center;Messenger RNA;Mitochondria;Modeling;Modification;mouse model;Mus;Mutate;Myocardial dysfunction;Myocardial Infarction;Myocardial Ischemia;novel;novel therapeutic intervention;Organ;organ allocation;Outcome;Output;overexpression;Pathway interactions;Patients;Perfusion;Perioperative;Pharmaceutical Preparations;Play;pre-clinical;preservation;programs;protective effect;Proteins;Refractory;Reperfusion Injury;Reperfusion Therapy;Research;Resources;Risk;Role;side effect;single-cell RNA sequencing;Site;Stroke;Succinates;superoxide dismutase 1;Tamoxifen;Techniques;Therapeutic;therapy development;Time;transcription factor;Transgenic Mice;Translations;transplant model;Transplant Recipients;Transplantation;Treatment Failure;Tryptophan;United States Food and Drug Administration;Up-Regulation;Valproic Acid;Waiting Lists

PROJECT_TITLE: Targeting Immune-Responsive Gene 1 (Irg1) and Itaconate for Cardioprotection of the Donor Heart for Transplantation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: Project Narrative The aim of the proposed research is to understand the interactions between cerebral small vessel disease and Alzheimer’s Disease related pathology in the medial temporal lobe, a brain region crucial for cognition and affected by the disease at early stages. The combined use of ultra-high resolution ex vivo MRI, corresponding histopathological serial sectioning, and deep-learning based quantitative measures of MRI and histology is promising to quantitatively and objectively identify these relationships, also inferring the role of potential mechanisms, such as blood-brain barrier leakage and clearance dysfunction. The results will enhance our understanding of the causal links between vascular and AD pathology and produce histologically validated neuroimaging markers of microvascular health of the medial temporal lobe, which could potentially be applied in vivo to monitor the effects of much needed disease-modifying interventions.

PI_NAMEs: PEROSA, VALENTINA  (contact)

PROGRAM_OFFICER_NAME: ROVESCALLI, ALESSANDRA C

PROJECT_TERMS: 3-Dimensional;Address;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Amyloid;analytical method;Area;arteriole;Arterioloscleroses;Autopsy;Award;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;Brain region;brain tissue;burden of illness;Cerebral Amyloid Angiopathy;Cerebral small vessel disease;Cerebrovascular Disorders;Clinical;Cognition;Complex;Contrast Media;crosslink;deep learning;Dementia;Development;Disease;Disease Marker;early detection biomarkers;Ensure;entorhinal cortex;Etiology;Excision;Extravasation;Fibrin;Functional disorder;General Hospitals;global health;Goals;Health;Healthcare;Hippocampus;Histologic;Histology;Human;imaging modality;Impaired cognition;Impairment;in vivo;innovation;International;Intervention;Investigation;Knowledge;Link;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Massachusetts;Measures;medial temporal lobe;medical schools;Memory;Mentors;Metabolic;Methods;Monitor;Morphology;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;neuron loss;neuropathology;novel;Optical Coherence Tomography;Pathologic;Pathology;Pattern;Penetration;Phase;Predisposition;protein TDP-43;Proteins;quantitative imaging;Research;Research Personnel;Research Priority;Resources;Role;Senile Plaques;Site;skills;spatial relationship;System;tau aggregation;tau Proteins;training opportunity;Training Programs;ultra high resolution;United States National Institutes of Health;Vascular Diseases;Visualization;Waste Products;Work

PROJECT_TITLE: Understanding the mechanistic link between vascular dysfunction and Alzheimers disease-related protein accumulation in the medial temporal lobe

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Bioengineering

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative: My group develops biosensor tools that enable the visualization of enzymatic processes inside living cells as they move. This is an important area of study in basic biology because it increases understanding about mechanisms that differentiate normal cells (e.g., immune cells) from diseased cells (e.g., tumor cells) as they move and migrate throughout the human body. I will develop molecular imaging tools that enable the simultaneous recording of two different enzymatic protein activities in living cells, which will then allow me to decode the coordination of multiple signaling proteins that regulates cell movement.

PI_NAMEs: HODGSON, LOUIS  (contact)

PROGRAM_OFFICER_NAME: BARNES, CHARLES ASHLEY

PROJECT_TERMS: Area;Biology;Biosensor;cell motility;Cells;Cellular biology;chemokine;Chemotaxis;Data;design;Development;Disease;Fibroblasts;Fluorescence Resonance Energy Transfer;Guanosine Triphosphate Phosphohydrolases;Health;Human;Human body;imaging approach;Imaging Device;Immune;Inflammatory;Invaded;Macrophage;Malignant Breast Neoplasm;migration;Modality;Molecular;molecular imaging;monomer;Motility;multiplexed imaging;Neoplasm Metastasis;neoplastic cell;Normal Cell;novel;optogenetics;Pathway interactions;Process;Proteins;response;rho GTP-Binding Proteins;Role;Signal Pathway;Signal Transduction;Signaling Protein;System;Techniques;Technology;temporal measurement;Time;tool;tumor;Visualization

PROJECT_TITLE: Multiplex Imaging of Signaling Pathways in Cell Motility

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-Y(55)R]


NIH_SPENDING_CATS: Genetics

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative  Efficient DNA replication at hard-to-replicate sites is facilitated by specialized DNA helicases. Furthermore, proper assembly and regulation of telomeres is essential to maintain chromosome stability in Eukaryotes. Our goal is to understand how these processes function and are regulated. Mutations in DNA helicases in humans and telomere de-regulation are associated with genome instability, a hallmark of several syndromes, cancer and ageing.

PI_NAMEs: GALLETTO, ROBERTO  (contact)

PROGRAM_OFFICER_NAME: REDDY, MICHAEL K

PROJECT_TITLE: Functions of DNA helicases at hard-to-replicate sites and telomere regulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Dissemination and Implementation Research;Emergency Care;Health Services;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: ATLANTA

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Interhospital fragmentation of care is an understudied risk factor for poor patient outcomes, including increased mortality, higher costs, and increased healthcare waste. This study focuses on potential causes of and solutions to interhospital care fragmentation among older adults with Alzheimer’s disease and related dementias. Findings from this study will provide additional insight into the impact of interhospital care fragmentation in this population, and could provide novel approaches for directly reducing care fragmentation as well as mitigating the negative effects of fragmented readmissions.

PI_NAMEs: TURBOW, SARA DIANE (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;Administrator;Admission activity;Age;Aging;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease patient;Alzheimer's disease related dementia;Ambulances;American Hospital Association;beneficiary;care fragmentation;Caring;Certification;Clinical;Code;Computer software;Continuity of Patient Care;cost;cost comparison;Data;Data Analyses;data sharing;Databases;Dementia;dementia care;design;empowerment;experience;Faculty;Family;Fee-for-Service Plans;Foundations;Friends;Funding;Future;Geriatrics;Grant;Harm Reduction;Health;Health care facility;health care settings;Health Disparities Research;health economics;Health Professional;health record;Health Services;Health Services Research;Health Surveys;Health system;Healthcare;High Prevalence;high risk;hospital care;Hospital Mortality;hospital readmission;Hospitalization;Hospitals;human old age (65+);ICD-9;Image;implementation science;improved;Information Technology;Inpatients;insight;Intervention;Interview;Investigation;K-Series Research Career Programs;Lead;Link;Location;medical specialties;Medicare;Mentorship;Methods;metropolitan;Mission;Modeling;Mollies;mortality;mortality risk;multidisciplinary;National Institute on Aging;novel strategies;older adult;Older Population;Outcome;Outpatients;Patient Readmission;Patient-Focused Outcomes;Patients;Perception;Persons;point of care;policy implication;Population;Positioning Attribute;Prevalence;prevent;programs;Protocols documentation;Provider;Qualitative Methods;Quality of Care;Questionnaires;Research;Research Personnel;residence;Resources;Risk Factors;Structure;Surveys;System;Testing;Training;transmission process;Universities;wasting;Work

PROJECT_TITLE: iCAREFOR: Interhospital Care Fragmentation in Older Adults with Dementia

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Autoimmune Disease;Biotechnology;Clinical Research;Digestive Diseases;Genetics;Inflammatory Bowel Disease;Microbiome;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Inflammatory bowel diseases (IBD) are now considered global diseases with fastest growing incidence among young patients diagnosed before 6 years of age. The pathophysiology of IBD remains incompletely understood involving the importance of the microbiome and more recently, the virome and available therapies remain ineffective in a large number of patients with IBD. This project will serve to better understand the mechanistic contribution of interferon lambdas (IFNλs) in maintaining intestinal homeostasis, preventing development of IBD and their therapeutic potential.

PI_NAMEs: OUAHED, JODIE  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: 5 year old;6 year old;Acute;Age;Age Months;Award;Biological Assay;Biopsy;career development;causal variant;Cell Culture Techniques;cell type;Cells;Child;Colitis;curative treatments;cytokine;Data;Development;Diagnosis;Disease;early onset;efficacy evaluation;Epithelial Cells;Epithelium;Equipoise;experience;Experimental Models;Exposure to;Functional disorder;functional genomics;Gastrointestinal tract structure;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genomics;Goals;gut homeostasis;gut inflammation;Gut Mucosa;healing;Hematopoietic;Hepatitis B;HIV;Homeostasis;Human;IFNGR1 gene;Immune;immune function;Immune signaling;Impairment;improved;In Vitro;in vivo;Incidence;infancy;Infant;Inflammatory Bowel Diseases;Inherited;Interferon alpha;Interferon Type I;Interferon Type II;Interferons;intestinal barrier;intestinal epithelium;intestinal homeostasis;Intestines;Life;Link;Mentors;microbiome;microbiome components;microorganism;Modeling;Molecular;Mucous Membrane;murine colitis;Mus;Mutation;North America;novel;novel strategies;Organoids;Oxidative Stress;Pathway interactions;Patients;Pattern;Peripheral Blood Mononuclear Cell;Physicians;Play;Predisposition;Prevalence;prevent;Production;Proliferating;receptor;Reporting;response;Role;SARS-CoV-2 P.1;Scientist;Severities;Signal Transduction;single-cell RNA sequencing;skills;Structure;Technology;Therapeutic;Therapeutic Uses;Time;Tissues;tool;Training;transcriptome sequencing;Translating;Variant;Viral;Viral Physiology;virome;Virus;Virus Diseases;Wild Type Mouse;Work

PROJECT_TITLE: Role of Interferon lambda signaling in mucosal homeostasis and infantile-onset inflammatory bowel disease

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Dissemination and Implementation Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Lung;Networking and Information Technology R&D (NITRD);Pediatric;Social Determinants of Health;Telehealth

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE: Lower respiratory infections are the leading infectious cause of death for children younger than five years of age in low-income and middle-income countries (LMICs) like South Africa. Innovations in the identification of severe pediatric respiratory diseases complicated by low oxyhemoglobin saturation levels (hypoxemia) that are suitable for use in rural communities of LMICs are urgently needed to reduce mortality. An affordable mobile phone-based reflectance pulse oximeter with electronic health diagnostic and surveillance capabilities that is also contextually appropriate for LMICs offers an exciting potential for improving outcomes for severe pediatric lower respiratory infections.

PI_NAMEs: MCCOLLUM, ERIC DOUGLASS (contact)

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: 2019-nCoV;5 year old;acceptability and feasibility;Address;Adult;Affect;Africa;Africa South of the Sahara;African;Asia;Award;blood perfusion;Breathing;Caregivers;Cause of Death;Cellular Phone;Cessation of life;Child;Child health care;Childhood;Clinic;Clinical;Communities;cost;Country;COVID-19;COVID-19 treatment;Dehydration;design;Development;Developmental Process;Devices;Diagnosis;Diagnostic;Disease;Ecosystem;eHealth;electronic health system;Ensure;experimental study;field study;Fingers;Focus Groups;Goals;Health;Health Services;Health Services Accessibility;Health system;High Prevalence;human centered design;Hypoxemia;ideation;implementation evaluation;implementation fidelity;implementation outcomes;improved;improved outcome;Income;innovation;interoperability;Interview;Laboratories;Language;Life;Low income;Lower Respiratory Tract Infection;Measurement;Measures;Morphologic artifacts;mortality;mortality risk;Motion;multidisciplinary;noninvasive diagnosis;Outcome;Oxygen;Oxyhemoglobin;pandemic disease;Pathway interactions;Performance;Peripheral;peripheral blood;Phase;Physiologic pulse;Prevalence;Primary Health Care;primary outcome;Process;product development;prototype;Questionnaires;Randomized, Controlled Trials;Research;Respiratory Disease;response;Rural Community;scale up;secondary outcome;signal processing;South Africa;South African;Standardization;success;Surface;System;Technology;Testing;Theory of Change;Thinking;Time;Toes;treatment center;United States National Institutes of Health;viral pandemic;Work

PROJECT_TITLE: Development and implementation of pediatric mobile phone reflectance pulse oximeters and a hypoxemia surveillance system in South Africa


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Emergency Care;Health Services;Networking and Information Technology R&D (NITRD);Prevention;Telehealth

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

PHR: PROJECT NARRATIVE Healthcare workers’ (HCWs’) willingness to report to work during pandemics and other public health emergencies and disasters is a foundational prerequisite for national, regional and global health security in the face of an ever-broadening array of emergent population-health threats. Well-documented case reports point to concerning gaps in public health emergency and disaster response willingness, including among low- and middle- income country (LMIC)-based HCWs, and research to date in LMICs and other settings has highlighted HCWs’ self-efficacy as leading predictor of their willingness to respond in these types of events. The purpose of this two-part study is to develop, measure the effectiveness of, and refine a novel mHealth intervention using an evidence-informed approach for building self-efficacy and enhancing response willingness among LMIC-based emergency department HCWs in public health emergencies and disasters.

PI_NAMEs: ASAD, NARGIS ;BARNETT, DANIEL JEREMY (contact);RAZZAK, JUNAID ABDUL

PROJECT_TERMS: Accident and Emergency department;Address;Area;Attitude;Case Study;Clinical;Consumption;Control Groups;Data Collection;design;digital data;Disasters;Educational Curriculum;Educational Intervention;Educational workshop;Effectiveness;effectiveness measure;effectiveness trial;Emergency Care;Emergency Medicine;Emergency Situation;Event;Exhibits;expectation;global health;group intervention;Group Interviews;hazard;Health;health assessment;Health Personnel;Health Professional;Health system;Health Technology;Hour;Human Resources;insight;Intervention;Intervention Studies;Knowledge;low and middle-income countries;man;Measures;Medical center;mHealth;mhealth interventions;Mobile Health Application;Motivation;novel;online course;Outcome;Pakistan;pandemic disease;Perception;Persons;Phase;pilot test;Politics;population health;pressure;public health emergency;Publishing;Questionnaires;Randomized, Controlled Trials;Readiness;Reporting;Research;Resources;response;Role;Security;Self Efficacy;Structure;Testing;Time;tool;Training;Universities;webinar;willingness;Work

PROJECT_TITLE: iRise: Willingness of Low-and Middle-Income Country-based Health Workers to Respond to Public Health Emergencies and Disasters - an mHealth Intervention Study


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Neurodegeneration, particularly of the basal forebrain, is strongly associated with both cognitive and sensory deficits. Through this research we will develop a mechanistic understanding of how basal forebrain circuits mediate downstream effects on sensory processing, potentially revealing common mechanisms that underlie sensory and cognitive deficits in disease. Revealing these mechanisms will improve our understanding of circuit defects in neurodegenerative disease and may lead to novel, targeted therapies for treating dementia and sensory deficits.

PI_NAMEs: MOSS, ELIZABETH HANSON (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Address;Alzheimer's Disease;Arousal;Attention;Award;basal forebrain;Behavioral;behavioral response;Bilateral;Brain;cell type;Cells;cholinergic;Cholinergic Receptors;Code;Cognition;Cognitive;Cognitive deficits;cognitive function;Collaborations;Complex;computer framework;Computing Methodologies;Conscious;Data;Defect;Dementia;design;Disease;Electrophysiology (science);Esthesia;experience;Fiber;flexibility;Food;Functional disorder;Future;genetic manipulation;Goals;Image;imaging approach;imaging platform;improved;in vivo;in vivo imaging;in vivo two-photon imaging;Learning;Link;Mediating;Mediator;Mentors;Mentorship;mixed dementia;Modeling;Monitor;Motivation;Nerve Degeneration;neural circuit;Neurodegenerative Disorders;Neurons;neuropsychiatric disorder;Neurosciences;novel;novel therapeutics;Odors;olfactory bulb;Olfactory Learning;Olfactory Pathways;optogenetics;Output;Parkinson Disease;Pathway interactions;Pattern;Phase;Photometry;Play;Population;programs;Property;recruit;Regulation;Research;Research Personnel;response;Rewards;Role;Sensory;sensory input;Signal Transduction;skills;Smell Perception;spatiotemporal;Speed;Stimulus;Synapses;System;targeted treatment;Techniques;temporal measurement;Testing;therapeutic target;Time;Training;two photon microscopy;two-photon;Work

PROJECT_TITLE: Mechanisms of basal forebrain control over sensory processing


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Volatile anesthetics induce all stages of general anesthesia including unconsciousness, amnesia, analgesia and muscle relaxation, but we have no satisfactory answer as to how this occurs physiologically. Using novel fluorescent microscopy in C.elegans, we are now able to image neuronal activity in real-time, in vivo, and at resolutions capable of capturing the activity of individual neurons and entire populations of complex neuronal networks simultaneously. Our experimental system, and its progressive extension into higher-order animals, will allow us to measure the activity of the individual identifiable neurons within large-scale neuronal circuits to understand how subtle modifications in discrete neuronal dynamics lead to the gross but reversible functional defects at the level of the overall nervous system that produce the clinical state of anesthesia in both simple creatures and humans.

PI_NAMEs: CONNOR, CHRISTOPHER W (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Absence of pain sensation;Amnesia;Anesthesia procedures;Anesthesiology;Anesthetics;Animals;Architecture;awake;Back;Behavior;Brain region;Caenorhabditis elegans;Calcium;Chemicals;Clinical;clinical risk;Communication;Complex;connectome;Conscious;Defect;differential expression;Diffuse;drug action;Elderly;Electroencephalography;experimental study;Exposure to;fluorophore;Functional Imaging;functional magnetic resonance imaging/electroencephalography;General Anesthesia;Human;Image;Image Analysis;in vivo;Individual;infancy;Isoflurane;late life;Lead;Length;Light;Measurement;Measures;medical specialties;Microscopy;Modification;Molecular Analysis;Mus;Muscle relaxation phase;Nervous System;neural network;Neurodevelopmental Impairment;neuronal circuitry;Neurons;novel;Operative Surgical Procedures;Pathway interactions;Phylogenetic Analysis;Physiological;Population;post-operative cognitive dysfunction;Problem behavior;promoter;receptor;Research;Resolution;Signal Transduction;Somatosensory Cortex;Supercomputing;Synapses;System;Techniques;Time;two-photon;Unconscious State;Volatilization;Zebrafish

PROJECT_TITLE: Pan-neuronal functional imaging and anesthesia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-D(55)R]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Neurosciences;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: DURHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE Alcohol use disorder is a destructive mental disorder that impacts nearly 15 million American adults, but many key risk factors point to developmental perturbations as important contributors to disease. My preliminary data point to a critical developmental role of microglia, the brain’s innate immune cells, and their impact on maturing parvalbumin GABAergic interneurons, in increased voluntary alcohol consumption in adulthood. This proposed study will answer both basic neurodevelopmental questions about microglial sculpting of inhibitory maturation in the frontal cortex and seek to identify a mechanism through which developmental microglial signaling changes influence excessive drinking behavior to improve our understanding of alcohol use disorders.

PI_NAMEs: DZIABIS, JULIA  (contact)

PROGRAM_OFFICER_NAME: CUI, CHANGHAI

PROJECT_TERMS: 3-Dimensional;Ablation;Acute;Adaptor Signaling Protein;Adolescence;Adult;Alcohol abuse;alcohol abuse therapy;Alcohol consumption;Alcohol dependence;alcohol exposure;alcohol use disorder;Alcohols;American;Animals;Automobile Driving;Behavior;behavior change;Bilateral;Brain;Cells;Chronic;cognitive function;comparison control;Conceptions;Corpus striatum structure;Darkness;Data;density;Designer Drugs;designer receptors exclusively activated by designer drugs;Development;Disease;drinking;drinking behavior;Drug Design;early drinking;Early identification;Early Intervention;early life stress;Economic Burden;Exhibits;experimental study;frontal lobe;Functional disorder;Future;Gene Expression Profiling;genetic approach;Goals;health economics;Heavy Drinking;Image;Immune;Immune signaling;Immunohistochemistry;improved;Individual;Inflammation;Inflammatory;Inhibitory Synapse;Injections;Interneuron function;Interneurons;Knowledge;late life;Life;loss of function;male;Measures;meetings;Mental disorders;Microglia;Morbidity - disease rate;mortality;Mus;Myelogenous;Nervous System Disorder;neural circuit;Neurobiology;Neurons;neurotransmission;neutrophil;novel;Operative Surgical Procedures;Outcome;Parvalbumins;Phagocytosis;Population;Predisposition;Prevention;Process;Protocols documentation;receptor;reconstruction;Relapse;Research;response;Risk Factors;Role;Shapes;Signal Transduction;Signaling Molecule;socioeconomics;Synapses;synaptic pruning;Techniques;Testing;theories;Tissues;Toll-like receptors;Training;United States;Wild Type Mouse;Work

PROJECT_TITLE: A novel role for developmental microglial-parvalbumin interneuron interactions in adult alcohol drinking behavior.


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Hearing Loss;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative:  Recent evidence indicates that sensorimotor changes may precede the onset of AD dementia by up to 10 years. Hearing is an important sense, and compared with other sensory systems, auditory system has the advantage that decline in function over time can easily be quantitatively measured by electrophysiological recordings. In this project, we will assess AD-induced functional and pathological changes in the auditory system and identify the impact of hearing loss on AD and dementia development and progression to identify and characterize early, sensitive, and non-invasive AD biomarkers, which can be expected to have great impact on the early detection and diagnosis of AD and also are desperately needed for prevention and therapeutic interventions of AD/ADRD.

PI_NAMEs: ZHAO, HONG-BO  (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acceleration;Acoustic Stimulation;Acoustics;age effect;age related decline;aging population;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;APP-PS1;Area;Auditory;Auditory Evoked Potentials;auditory pathway;Auditory system;behavior test;Behavioral;Biological Markers;Brain;CBA/CaJ Mouse;Cell Nucleus;Cognitive;Conflict (Psychology);cost;Dementia;dementia risk;Detection;Development;Diagnosis;early detection biomarkers;Early Diagnosis;Electrophysiology (science);epidemiology study;familial Alzheimer disease;functional decline;Genetic;Genomics;Goals;Hearing;hearing impairment;Hearing problem;high risk;Human;Human Amyloid Precursor Protein;Impaired cognition;improved;Link;Measures;Memory;Memory Loss;Motor;mouse model;Mus;mutant;Mutation;Nerve Degeneration;neural;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurons;normal aging;Outcome Measure;Pathologic;Photic Stimulation;Presbycusis;Prevalence;Prevention;preventive intervention;protein aggregation;protein expression;Role;screening;Sensory;sensory system;spiral ganglion;Startle Reaction;Symptoms;System;tau Proteins;Techniques;Testing;Therapeutic Effect;Therapeutic Intervention;Time;transcriptome sequencing;TREM2 gene

PROJECT_TITLE: Hearing Biomarkers in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AN-Q(55)]


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Breast Cancer;Breastfeeding, Lactation and Breast Milk;Cancer;Maternal Health;Microbiome;Nutrition;Pediatric;Prevention;Women's Health Research

ORG_CITY: HADLEY

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF MASSACHUSETTS AMHERST

PHR: Project Narrative Maintaining a healthy breast microenvironment that supports optimal lactation, as well as the ideal nutrient composition, is important for the growth and development of the human-milk-fed infant. Subclinical mastitis (SCM), an asymptomatic inflammation of mammary tissue during lactation, has been linked with low milk supply, reduced nutritional composition and reduced microbial diversity, yet the prevalence of SCM in the US is unknown. We propose to fill this significant gap by following temporal changes in milk in two lactating US populations to determine the prevalence, as well as the impact on milk composition and infant health, as it relates to the occurrence and severity of SCM.

PI_NAMEs: ARCARO, KATHLEEN FRANCES (contact);SCHNEIDER, SALLIE SMITH

PROGRAM_OFFICER_NAME: DEYAMPERT, TARA LYNN

PROJECT_TERMS: 37 weeks gestation;Academy;Address;Affect;Allergic Disease;American;Anti-Inflammatory Agents;Antibodies;Antibody-mediated protection;Autoimmune Diseases;Bacteria;Behavioral;Bilateral;Birth;Black race;Breast;Breast Feeding;Carbohydrates;clinical practice;clinically relevant;cohort;Cohort Studies;Counseling;cytokine;Data;dietary;Dietary Intervention;dysbiosis;Elements;Enrollment;ethnic diversity;Fatty acid glycerol esters;gastrointestinal epithelium;Geography;Goals;Growth;Growth and Development function;Growth Factor;gut microbiome;Health;Health Benefit;Hispanic;Human;Human Milk;Immune;Immune system;improved;improved outcome;Indigenous;Infant;Infant Health;infection risk;Inflammation;Inflammatory;Intervention;Intestines;Knowledge;Lactation;Life;Link;Literature;Longitudinal Studies;Maintenance;mammary;mammary epithelium;Massachusetts;mastitis;Measures;microbial;microbiome;microbiome composition;Milk;milk microbiome;milk removal;milk secretion;milk supply;Mothers;New Mexico;novel;Nutrient;Nutritional;obesity in children;Outcome;Parents;Participant;Pathway interactions;Pattern;Pediatrics;Perception;Periodicals;Permeability;Pharmaceutical Preparations;Physiological;Physiology;Population;Postpartum Period;Pregnant Women;Prevalence;prevent;Probiotics;Proteins;Public Hospitals;Questionnaires;racial diversity;Recommendation;recruit;Reporting;Research;Risk Factors;Role;Severities;Sodium;stool sample;Supplementation;Systems Development;Testing;Third Pregnancy Trimester;Tissues;United States;Weaning;Woman;Work

PROJECT_TITLE: Mammary Epithelium Permeability, Lactation Outcomes, and Infant Health

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Aging;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Emerging Infectious Diseases;Infectious Diseases;Lung;Rare Diseases

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: PROJECT NARRATIVE The mortality of the Acute Respiratory Distress Syndrome (ARDS) increases significantly with age, an epidemiological trend vehemently underscored by the COVID-19 pandemic. Inflammation and senescence are established aging related processes which may mechanistically contribute to the poor clinical outcomes seen in older adults with ARDS. This proposal will test the relationships between age (biological and chronological), inflammation, and clinical outcomes in ARDS while beginning to define a novel senescent phenotype of ARDS.

PI_NAMEs: LEVINE, ANDREA  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 2019-nCoV;Acute Respiratory Distress Syndrome;Age;age related;Aging;aging related;Biological;biological age;Biological Aging;biological heterogeneity;Biological Markers;Cell Aging;Cell Cycle Arrest;Cells;Cessation of life;chemokine;Chronology;Clinical;Clinical Data;Clinical Trials;cohort;comorbidity;Coupled;COVID-19;COVID-19 pandemic;COVID-19/ARDS;cytokine;Data;Development;differential expression;effective therapy;Elderly;Epidemiological trend;Etiology;Future;Genetic;Grant;Hand;Hypoxemia;Hypoxia;IL8 gene;Immune;Immune response;Impairment;Infection;Infiltration;Inflammaging;Inflammation;Inflammatory;Inflammatory Response;Interferon Type II;Interleukin-6;Intervention;Knowledge;Length;Leukocytes;Life;Link;Measures;Mediator;Mentors;Modeling;mortality;non cardiogenic pulmonary edema;novel;older adult;Outcome;pathogen;Pathway interactions;Patients;peripheral blood;Phenotype;Plasma;Plasma Proteins;Predisposition;Process;prognostic;prognostic value;protein biomarkers;Publishing;Pulmonary Diffusing Capacity;Research;Research Support;Risk Factors;Role;Sampling;senescence;senescent cell;Severities;telomere;Telomere Shortening;Testing;Training;Virus;Work;young adult

PROJECT_TITLE: The Association Between Aging, Inflammation, and Clinical Outcomes in Acute Respiratory Distress Syndrome


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: PROJECT NARRATIVE – Overall The Center for Chronic Disease Reduction and Equity Promotion Across Minnesota (C2DREAM) will reduce disparities in cardiovascular disease (CVD) and the related chronic conditions (RCC) of hypertension and obesity experienced by Black, Indigenous, and people of color (BIPOC) communities including immigrants and refugees across Minnesota. C2DREAM will promote innovative, multilevel interventions that target fundamental causes of chronic disease inequities among BIPOC communities; generate knowledge, analytical and implementation approaches, and community engagement strategies to understand and develop solutions to address racism at multiple levels; develop and support the next generation of health equity researchers; create and sustain a community-engaged and equity-guided dissemination and implementation processes to translate research results and knowledge into action; and employ equity-guided evaluation approaches. Our regional partnership of academic institutions and community stakeholders is poised to understand and ultimately address the ways that racism undermines the well-being of BIPOC communities across Minnesota.

PI_NAMEs: ALLEN, MICHELE L (contact);HARDEMAN, RACHEL R;PATTEN, CHRISTI A

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: Address;Adult;Automobile Driving;Behavioral Medicine;Black, Indigenous, People of Color;Cardiovascular Diseases;career;Chronic;Chronic Disease;Clinic;clinical center;Clinical Sciences;clinical translation;Communication;Communities;community based participatory research;community center;community engaged approach;community engagement;Community Healthcare;Community Networks;County;Development;Diet;disease disparity;Disease Outcome;disorder risk;Disparity;disparity reduction;Dissemination and Implementation;dissemination science;Early Intervention;Effectiveness of Interventions;Epidemiology;Equity;Evaluation;evidence base;experience;Family;Funding;Grant;Hand;Health Disparities Research;health equity;Health equity research;health inequalities;Health Promotion;Health system;Healthcare;Hospitals;Hypertension;Immigrant;implementation process;implementation science;Inequity;innovation;Institution;Intervention;Intervention Studies;Knowledge;Latinx;Leadership;Longevity;Measurement;medical schools;Medicine;Mentorship;Minnesota;minority health;Mission;model design;Modeling;multimodality;Murder;National Center for Advancing Translational Sciences;National Institute on Minority Health and Health Disparities;Native Americans;next generation;Obesity;obesity treatment;outcome disparities;Personal Satisfaction;Physical activity;Police;Policies;Positioning Attribute;prevent;preventive intervention;Primary Care;primary care patient;Process;programs;Psychology;Public Health;Public Health Schools;racism;Refugees;Research;Research Personnel;Research Project Grants;Resources;safety net;smoking cessation;Structural Racism;System;Targeted Research;Techniques;Training;Translating;Translational Research;Translations;Twin Cities;Universities;Work;Youth


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: ALLEN, MICHELE L (contact)

PROJECT_TERMS: Address;behavior change;Black, Indigenous, People of Color;Cardiovascular Diseases;Chronic;Chronic Disease;Collaborations;Communication;Communities;Creativeness;Data Collection;Disparity;Elements;Ensure;Equity;Evaluation;flexibility;Fostering;Foundations;Goals;health belief;health equity;Health equity research;Hypertension;implementation process;Infrastructure;innovation;Institution;inter-institutional;Knowledge;Leadership;Measures;Methods;Minnesota;Mission;Modeling;multimodality;Obesity;Policy Maker;Productivity;racism;Research;Research Personnel;Research Project Grants;Rural;Source;success;Translating;Treatment Efficacy

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Cardiovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: EVERSON-ROSE, SUSAN A. (contact)

PROJECT_TERMS: Address;Affect;Applications Grants;Black, Indigenous, People of Color;Cardiovascular Diseases;career development;Chronic;Chronic Disease;Clinic;Communities;community burden;community engagement;community organizations;community planning;Data;data management;design;Development;disease disparity;Disparity;Educational workshop;effectiveness evaluation;empowerment;Equity;experience;Faculty;Financial Support;Funding;Future;Goals;Grant;health care availability;health disparity;health disparity populations;health equity;Health equity research;Health Priorities;Healthcare;Hypertension;improved;Incubators;Infrastructure;innovation;Institution;Intervention Studies;Logic;Manuscripts;medical schools;Medicine;Mentors;Mentorship;Methods;Minnesota;Modeling;modifiable risk;multidisciplinary;National Institute on Minority Health and Health Disparities;next generation;Obesity;Outcome;Outcome Measure;Pathway interactions;peer;Peer Review;Pilot Projects;Postdoctoral Fellow;Preparation;Prevention;Process Measure;Productivity;programs;Public Health Schools;racism;recruit;Research;Research Personnel;Research Training;Resources;Risk Factors;Science;Series;Services;skills training;Smoking;social determinants;Statistical Data Interpretation;structural determinants;success;Surveys;symposium;Targeted Research;tool;Training;Travel;Underrepresented Populations;United States National Institutes of Health;Work;Writing

PROJECT_TITLE: Investigator Development Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Childhood Leukemia;Hematology;Immunization;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Radiation Oncology;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE Widely expressed on acute myeloid leukemia (AML) cells, CD33 is of great interest as a therapeutic target for this highly aggressive blood cancer, but current CD33-directed drugs are often ineffective. Using newly raised CD33-binding antibodies, the Walter Lab plans to optimize the efficacy and safety of CD33-targeted therapy, focusing efforts on the delivery of highly potent radioisotopes, a treatment approach called radioimmunotherapy. Dr. George S. Laszlo, PhD, the Research Specialist in the Walter Lab since 2010, has developed all experimental methodologies, approaches, assays, and tools/reagents that build the foundation for this research and will lead studies over the next 5 years that have the explicit goal of bringing new therapy options to patients with AML.

PI_NAMEs: LASZLO, GEORGE S (contact)

PROGRAM_OFFICER_NAME: BOURCIER, KATARZYNA

PROJECT_TERMS: Acute Myelocytic Leukemia;acute myeloid leukemia cell;Alpha Particles;Antibodies;Antibody-drug conjugates;Astatine;bench to bedside;Binding;Biological Assay;Blood Cells;Cell Line;Cell Physiology;Cells;Clinical;Development;Disease;Distal;Doctor of Philosophy;drug efficacy;Drug Targeting;drug testing;Effector Cell;Foundations;Gemtuzumab Ozogamicin;gene-editing approach;Generations;genetically modified cells;Goals;Hematopoietic Neoplasms;Hematopoietic stem cells;Human;human monoclonal antibodies;Immunotherapy;improved outcome;In Vitro;in vivo;Infrastructure;Institution;interest;Joints;Laboratories;Lead;member;Membrane;Methodology;Monoclonal Antibodies;Myelosuppression;novel;novel therapeutics;patient subsets;Patients;Peer Review;Pharmaceutical Preparations;Process;Production;programs;Publications;Radiation Tolerance;Radioimmunotherapy;Radioisotopes;Reagent;Recombinants;Research;Research Project Grants;Research Support;Safety;SET Domain;skills;Specialist;Supervision;targeted treatment;Therapeutic;Therapeutic Monoclonal Antibodies;therapeutic target;tool;Toxic effect;Training;United States National Institutes of Health;Validation;Variant;Work

PROJECT_TITLE: Optimizing the Efficacy and Safety of CD33-Targeted Immunotherapy for Acute Myeloid Leukemia and Other CD33+ Disorders


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: PRATT, REBEKAH J. (contact)

PROJECT_TERMS: Academic Training;Address;anti-racism;Area;Black, Indigenous, People of Color;Cardiovascular Diseases;Chronic;Chronic Disease;Communication;Communities;community engaged approach;community engagement;community engagement process;Community Health;community involvement;community organizations;community partners;community partnership;community-centered;Consultations;data visualization;design;Discrimination;Disease Outcome;disorder risk;Disparity;disparity reduction;Equity;ethnic minority;evidence base;experience;Fostering;Foundations;Goals;Grant;Health;health disparity;Hypertension;implementation intervention;Infrastructure;innovation;Investments;Knowledge;Leadership;Minnesota;Modeling;Multimedia;Obesity;Outcome;outcome disparities;Pilot Projects;Policies;Prevention;Process;Public Health;racial disparity;racial health disparity;racial minority;racism;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Research;Research Project Grants;Resources;Risk;Structure;success;System;Training;Translating;Translational Research

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_DEPT: NEUROLOGY

PHR: PROJECT NARRATIVE The purpose of this project is to study and promote brain activity patterns that support healthy memory function in healthy aging and in people at elevated risk for Alzheimer’s disease. We will use non-invasive brain stimulation to promote optimal activity patterns and to enhance memory function in healthy older adults and those with mild cognitive impairment. Successful completion of the proposed work has the potential to enhance the efficacy of brain stimulation for treating cognitive disorders.

PI_NAMEs: DAVIS, SIMON W (contact)

PROGRAM_OFFICER_NAME: MCLINDEN, KRISTINA

PROJECT_TERMS: Accounting;Address;Adult;Aging;Alzheimer's Disease;Alzheimer's disease risk;Award;Behavior;Behavioral;Biological Assay;Biological Markers;Blood Vessels;Brain;brain control;brain health;Brain Injuries;Brain region;care costs;Cerebrovascular Disorders;cerebrovascular pathology;Clinical;clinical application;Clinical Trials;Cognition;Cognition Disorders;Cognitive;cognitive ability;cognitive function;cognitive performance;cohort;combat;comparison control;computer framework;Dementia;density;Disease;Disease Progression;disorder risk;dosage;Dose;Electroencephalography;experimental study;Failure;flexibility;Frequencies;Functional disorder;Functional Magnetic Resonance Imaging;functional magnetic resonance imaging/electroencephalography;Future;Goals;healthy aging;Human;Impairment;improved;Individual;individual response;insight;Intervention;Link;Maps;Measures;Mediating;Mediation;Memory;memory encoding;Memory impairment;mild cognitive impairment;Modeling;Monitor;multimodality;Nature;neglect;network models;Network-based;neural;neural circuit;neurodegenerative dementia;Neuronal Plasticity;neurophysiology;neuroregulation;Neurosciences;neurovascular;noninvasive brain stimulation;novel;older adult;Outcome;Patients;Pattern;Performance;Persons;Pharmacotherapy;Population;preclinical study;Predictive Factor;Prefrontal Cortex;Process;Protocols documentation;Public Health;Reaction;recruit;Resolution;response;Risk;Scheme;Short-Term Memory;Site;spatiotemporal;success;Syndrome;System;Techniques;Time;Titrations;Transcranial magnetic stimulation;Work

PROJECT_TITLE: Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia