ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_DEPT: VETERINARY SCIENCES

PHR: PROJECT NARRATIVE This project uses a piglet model of Legg-Calvé-Perthes disease (LCPD), a pediatric disease affecting the hip, to determine the cell signaling changes that underlie tissue damage observed on the microscopic level and with MRI. By learning about the cell signaling, we will better understand the biology of the disease and we can determine whether a particular treatment that is effective in adults might be appropriate in children with LCPD. The children most likely to benefit are those that have a growth disturbance secondary to this disorder.

PI_NAMEs: ARMSTRONG, ALEXANDRA PR (contact)

PROGRAM_OFFICER_NAME: TANDON, RITESH

PROJECT_TERMS: Acute;Address;Adult;Affect;Animal Model;Appearance;Appointment;Attention;Automobile Driving;Bilateral;Biological Markers;Biological Process;Biology;candidate marker;career;Cartilage;Cartilage injury;cartilage repair;Cell Maturation;Characteristics;Child;Child Care;Child Health;Childhood;Chondrocytes;Clinical;clinical care;Clinical Management;Clinical Sciences;Complication;Consensus;Contralateral;Data;Dedications;Development;Diagnostic Procedure;diagnostic signature;differential expression;Disease;disease model;Disease Progression;Doctor of Philosophy;Down-Regulation;Early Diagnosis;Educational process of instructing;Educational workshop;effective therapy;Epiphysial cartilage;Evidence based treatment;experience;Faculty;Family suidae;Femur;femur head;Foundations;Functional disorder;Funding;Gene Expression;Gene Expression Profile;Genes;genetic signature;Genetic Transcription;genomic data;Genomics;Goals;Growth;Hemorrhage;high risk;Hip region structure;Histologic;Histology;Imaging Techniques;improved;Injury;insight;Intervention;Ischemia;ischemic injury;Knowledge;knowledge base;Leadership;Learning;Leg;Legg-Perthes Disease;Length;Magnetic Resonance Imaging;Measures;medical specialties;member;Mentored Research Scientist Development Award;Mentors;Methods;Microscopic;Molecular;Morphology;Musculoskeletal;musculoskeletal imaging;Neck;novel;Operative Surgical Procedures;Orthopedic Surgery;Orthopedics;Outcome;Pain;Pathogenesis;Pathology;Pathway interactions;Patients;Pattern;Perfusion;Physiologic Ossification;porcine model;Positioning Attribute;preservation;prevent;programs;radiological imaging;Recovery;Relaxation;repaired;Research;Research Personnel;response;Rheumatology;Role;Secondary to;Signal Transduction;Site;Surface;Surgeon;symposium;Techniques;tenure track;therapeutic target;Thick;Time;Tissues;Training;transcriptomics;Transforming Growth Factor beta;translational potential;Treatment Protocols;Uncertainty;Up-Regulation;Vascular blood supply;Work

PROJECT_TITLE: Spatialomics and quantitative MRI of ischemic injury in a piglet model of Legg-Calve-Perthes disease


ADMINISTERING_IC: DK

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_FIPS: US

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: OVERALL NARRATIVE Disparities in kidney health are profound; and for decades, have been documented for socially marginalized populations, yet little progress has been made to mitigate them. The overarching goal of the Johns Hopkins O’Brien Center to Advance Kidney Health Equity is to serve as a national resource for investigators conducting pre-clinical (basic), clinical or population health research addressing kidney health disparities, and make recommendations to inform strategies, interventions, and approaches aimed at achieving kidney health equity.

PI_NAMEs: CREWS, DEIDRA CANDICE (contact);PARIKH, CHIRAG R

PROGRAM_OFFICER_NAME: SCHULMAN, IVONNE HERNANDEZ

PROJECT_TERMS: Address;Advisory Committees;Basic Science;Behavior Therapy;biomedical resource;Biometry;Brain;burden of illness;Calibration;career;Clinical;Clinical Research;Clinical Sciences;Cohort Studies;Collaborations;Communities;community advisory board;Consultations;Diet;dietary;Dietary Assessment;Discipline;Discrimination;Disparity;Disparity population;Education;Ensure;epidemiology study;Equation;Ethnic Origin;experience;Fostering;Gender;Germ-Free;Goals;gut microbiota;Health;health disparity;health equity;Health equity research;Health Food;health inequalities;Health Promotion;Housing;humanized mouse;Incubators;Inequity;Infrastructure;innovation;Intervention;Intervention Studies;Joints;Kidney;Kidney Diseases;Laboratories;Lead;marginalization;marginalized community;marginalized population;microbiome;Mus;Nephrology;novel;outreach;Periodicals;Phenotype;population health;Population Heterogeneity;pre-clinical;pre-clinical research;Prevention Research;programs;Proteomics;Protocols documentation;Quality Control;Race;Recommendation;Research;Research Design;Research Personnel;Resource Development;Resources;Risk;Services;Sex Differences;social;social disparities;social health determinants;social stressor;Societies;Socioeconomic Status;socioeconomics;Stress;Structural Racism;Students;summer student;System;tool;translational scientist;Translations;Validation

PROJECT_TITLE: Johns Hopkins O'Brien Center to Advance Kidney Health Equity


NIH_SPENDING_CATS: Kidney Disease;Social Determinants of Health

PI_NAMEs: CREWS, DEIDRA CANDICE (contact)

PROJECT_TERMS: Achievement;Address;Advisory Committees;base;career;Clinical;Clinical Research;Clinical Trials;Collaborations;Communication;Communities;community advisory board;community partners;Disparity;Education;effectiveness evaluation;Endocrinology;Engineering;Ensure;Epidemiology;epidemiology study;Evidence based intervention;Fostering;Funding Mechanisms;Goals;Health;health equity;Health equity research;Health system;improved;Institution;Interest Group;Kidney;Medicine;Monitor;Nephrology;Outcome;outreach;Physiology;Policies;population health;pre-clinical;Prevention Research;Process;programs;Records;Reduce health disparities;Research;Research Infrastructure;Research Personnel;Resource Development;Resource Sharing;Resources;Science;Structure;Students;success;Sum;summer student;Training;University resources;Update;web site;Work

PROJECT_TITLE: JHU Admin Core


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Diabetes;Maternal Health;Neurosciences;Nutrition;Obesity;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: The proposed longitudinal study will provide a comprehensive picture of the biological underpinnings and the sequence of events that increase the risk of obesity and type 2 diabetes in children who were exposed in utero to mothers with gestational diabetes and/or obesity during pregnancy. The proposed work will contribute critical knowledge to breaking the vicious cycle of maternal-child obesity and type 2 diabetes that is contributing to one of the fastest growing global health problems.

PI_NAMEs: PAGE, KATHLEEN ALANNA (contact);XIANG, ANNY H

PROGRAM_OFFICER_NAME: WOO, THERESA TESLOVICH

PROJECT_TERMS: Adolescence;Adolescent;Age;Animal Model;Animals;Behavior;Beta Cell;Biological;biomarker identification;Body mass index;Brain;Brain Mapping;brain pathway;brain reward regions;Caring;Cell Physiology;Child;Childhood;cohort;Coupled;critical developmental period;Cross-Sectional Studies;cue reactivity;Data;Desire for food;Development;Diabetes Mellitus;diabetes risk;Diet;Eating;energy balance;Energy Intake;Event;Evolution;Exposure to;fetal programming;follow-up;Food;Functional disorder;Future;Future Generations;Gestational Diabetes;global health;Glucose;Hippocampus;Human;human study;Hypothalamic structure;Impairment;Insulin Resistance;insulin secretion;insulin sensitivity;Intervention;Knowledge;knowledge base;Lead;Life;Life Style;Link;Longitudinal Studies;maternal diabetes;maternal obesity;Measures;Mediating;Mediation;Metabolic;metabolic phenotype;Methods;Modeling;Modification;Mothers;neural;Neurobiology;neurodevelopment;neuroimaging;Neurosecretory Systems;Non-Insulin-Dependent Diabetes Mellitus;Obesity;obesity development;obesity in children;obesity in pregnancy;obesity risk;offspring;OGTT;Outcome;Pathogenesis;Pathway interactions;Personal Satisfaction;Phenotype;Physical activity;postnatal;Predisposition;Pregnancy Complications;prenatal exposure;prepregnancy;Prevalence;Puberty;Public Health;recruit;Regulation;response;Rewards;Risk;Risk Reduction;Rodent Model;Sampling;Satiation;Signal Transduction;Sleep;System;Testing;Time;transmission process;trend;type 2 diabetes in children;Weight Gain;Work;Youth

PROJECT_TITLE: Effects of prenatal exposures to maternal obesity and gestational diabetes on metabolic decline from childhood to adolescence and underlying neurobiological pathways

STUDY_SECTION: RPPH

STUDY_SECTION_NAME: Reproductive, Perinatal and Pediatric Health Study Section[RPPH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Nutrition;Obesity;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: WELLING, PAUL A (contact)

PROJECT_TERMS: Acceleration;Address;Affect;Animals;Basic Science;Behavior Therapy;biobank;Biological Models;Biology;biomedical resource;Biometry;Black race;burden of illness;Calorimetry;carbohydrate metabolism;caucasian American;Chronic Kidney Failure;Clinical Research;Clinical Sciences;Cohort Studies;Collaborations;Collection;Communities;Complex;Consultations;DASH diet;Data;Data Set;design;Diabetic Nephropathy;Diet;dietary;Dietary Assessment;disease disparity;Disease Outcome;Disease Progression;disorder risk;Disparity;Electrolytes;epidemiology study;Equipment;ethnic minority population;experience;experimental study;feeding;Fiber;follow-up;Food;food insecurity;Fostering;fundamental research;gene discovery;Genetic Models;Germ-Free;Goals;health disparity;health equity;health equity promotion;Health equity research;Health Food;Homeostasis;Human;human model;humanized mouse;Hypertension;Immunologics;Influentials;innovation;Intervention Studies;Investigation;Joints;Kidney;Kidney Diseases;Laboratories;Laboratory Research;lipid metabolism;marginalized community;member;Metabolic;Metabolism;microbiome;Minority;Modeling;Molecular;mouse model;Mus;Nutritional;Obesity;Obesity Epidemic;Observational Study;Pathway Analysis;Periodicals;Persons;Phenotype;Physiology;Pilot Projects;Population;Population Heterogeneity;Potassium;Potassium Deficiency;pre-clinical research;Prevention;Procedures;Process;Protocols documentation;Quality Control;Race;racial disparity;racial minority population;Research;Research Design;Research Personnel;Research Project Grants;Resources;Role;saturated fat;Services;social;social health determinants;social stress;social stressor;socioeconomic disparity;socioeconomics;Sodium;Specimen;Stress;stressor;Study models;sugar;Technology;tool;Training;Trans Fats;translational pipeline;Translational Research;translational study;Translations;Unhealthy Diet;Validation

PROJECT_TITLE: Biomedical Resource Core


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Down Syndrome;Intellectual and Developmental Disabilities (IDD);Mental Health;Pediatric

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE The proposed project will develop and validate a novel behavioral outcome measure, the Behavior Inventory for Down Syndrome (BIDS) for children and adolescents with Down syndrome, in both English and Spanish. Current clinical trials are plagued by the dearth of clinical outcome measures appropriate and sensitive for individuals with Down syndrome. As our field continues to develop new pharmaceutical and clinical interventions, our project will support this work and have an impact on the 400,000 individuals with Down syndrome living in the United States.

PI_NAMEs: ESBENSEN, ANNA J. (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: Adolescent;Affect;Age;aged;Behavior;Behavior assessment;behavior measurement;Behavioral;behavioral outcome;Caring;Characteristics;Child;Chronology;Clinic;Clinical;Clinical Data;clinical outcome measures;clinical practice;Clinical Trials;cohort;comorbidity;comparative;design;Development;Diagnosis;Down's Syndrome;effectiveness trial;efficacy trial;emotional functioning;Ensure;Equipment and supply inventories;Evaluation;evidence base;executive function;Family;Future;Genetic;Goals;Home environment;improved;Individual;Individual Differences;Informal Social Control;informant;Intellectual functioning disability;Intervention;Intervention Trial;Language;Language Development;Latinx population;Live Birth;Measurement;Measures;Medical;member;mental age;Mental Health;Methods;Modeling;Motor;National Institute of Child Health and Human Development;neurobehavioral;novel;Outcome;Outcome Assessment;Outcome Measure;Paper;Parents;Participant;Pattern;peer;Performance;Persons;Pharmacologic Substance;Phenotype;Population;Positioning Attribute;Process;Property;psychologic;Psychometrics;Reporting;Research;Research Priority;Research Project Grants;Sampling;sex;Site;skills;social;sound;Spanish;Spanish/English;Surveys;Telephone;Testing;theories;Time;Translational Research;treatment effect;treatment trial;United States;United States National Institutes of Health;Validity and Reliability;Variant;Vocation;Work;working group

PROJECT_TITLE: Behavior Measure for Children and Adolescents with Down Syndrome


NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Social Determinants of Health

PI_NAMEs: CORESH, JOSEF  (contact)

PROJECT_TERMS: Acceleration;Address;adverse outcome;Area;Basic Science;Biological Factors;biomedical resource;Blood;blood pressure regulation;Brain;Calibration;Clinical;Clinical Research;Clinical Sciences;Collaborations;Communities;data resource;design;Development;Disparity;Doctor of Philosophy;Ensure;Epidemiology;Equation;Equity;Financial Hardship;First Independent Research Support and Transition Awards;Foundations;Goals;gut microbiota;Health;health equity;Health equity research;health inequalities;Human;Incubators;innovation;Institution;interest;Investments;Kidney;Maintenance;Mediating;meetings;mid-career faculty;Modeling;mouse model;Mus;novel;Physiology;Policies;population health;professor;Proteomics;Public Health;Renal function;Research;Research Personnel;Resource Development;Resources;Risk;Role;Sampling;Scientist;Sex Differences;social health determinants;social metrics;social stressor;System;Technology;Testing;Tissues;tool;Urine;Work

PROJECT_TITLE: Resource Development Core


ADMINISTERING_IC: AI

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Pediatric;Prevention;Sexually Transmitted Infections

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Sexually transmitted infections (STIs) such as gonorrhea, chlamydia, and trichomoniasis are common in sub- Saharan Africa, and if left untreated they can increase the risk of HIV infection and lead to severe impacts on reproductive health. The proposed research will leverage the infrastructure of a clinical trial in rural South Africa to develop and evaluate a community-based method of screening for STIs among adolescents and young adults living with and at risk for HIV. We will measure uptake, acceptability, and process measures of the STI screening strategy in this population to inform future efforts to evaluate the effectiveness and implementation of scaled-up STI screening programs in South Africa.

PI_NAMEs: JAROLIMOVA, JANA  (contact)

PROGRAM_OFFICER_NAME: HUEBNER, ROBIN E

PROJECT_TERMS: accurate diagnostics;Address;Adolescent and Young Adult;Adoption;Affect;Africa;Africa South of the Sahara;African;AIDS prevention;behavior change;Biometry;Biostatistical Methods;career;Caring;Chlamydia;Clinic;Clinical;clinical epidemiology;Clinical Investigator;Clinical Trials;Clinical Trials Design;co-infection;Cohort Studies;Collaborations;Communicable Diseases;Communities;Country;Data;design;Diagnostic;Diagnostic tests;didactic education;Effectiveness;effectiveness evaluation;Enrollment;Epidemiology;Etiology;Evaluation;experimental study;Face;Foundations;Funding;Future;future implementation;Goals;Gonorrhea;Guidelines;Health;Health Services;Heterogeneity;high risk;HIV;HIV Infections;HIV/TB;Home;home test;Human immunodeficiency virus test;implementation determinants;implementation evaluation;implementation research;implementation science;improved;Incidence;Income;Individual;infection management;Infrastructure;interest;Interview;K-Series Research Career Programs;Left;Location;low and middle-income countries;Measures;men;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;Motivation;multidisciplinary;NIH Office of AIDS Research;novel;Nurses;Parents;Participant;pathogen;peer;Pelvic Inflammatory Disease;Persons;Physicians;Play;point of care testing;Population;Practical Robust Implementation and Sustainability Model;pre-exposure prophylaxis;preference;Pregnancy Complications;Prevalence;primary outcome;Process Measure;Provider;Qualitative Methods;Qualitative Research;rapid testing;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Recommendation;Reproductive Health;Research;Research Infrastructure;Research Institute;Research Methodology;Research Personnel;Research Priority;Risk;Role;rural South Africa;sample collection;Sample Size;Sampling;scale up;screening;screening program;Self Care;Sensitivity and Specificity;Sexual Health;sexual health intervention;Sexually Transmitted Diseases;skills;South Africa;Specimen;standard of care;STI prevention;structural determinants;Symptoms;Testing;Time;Training;transmission process;Trichomonas Infections;tubal infertility;United States National Institutes of Health;uptake;Woman;women's morbidity;Work;young woman

PROJECT_TITLE: Screening strategies for sexually transmitted infections in a high HIV incidence setting in South Africa

STUDY_SECTION: AIDS

STUDY_SECTION_NAME: Acquired Immunodeficiency Syndrome Research Study Section[AIDS]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE Since its inception, the Center for AIDS Prevention Studies (CAPS) has been at the forefront of conducting theory-driven, rigorous research to prevent new HIV infections, improve health outcomes among those infected and reduce significant HIV-related health disparities. The Center will build on its long and successful history of providing critical support to its cadre of world-class scientists that conduct interdisciplinary research to achieve an end to the HIV epidemic. .

PI_NAMEs: JOHNSON, MALLORY O (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adolescent;Affect;AIDS prevention;antiretroviral therapy;Area;Automobile Driving;Award;Behavioral Sciences;Black race;Caring;Clinic;Communities;Community Health;community organizations;Competence;Complex;condoms;Country;County;COVID-19 pandemic;design;Development;Diagnostic;Disparity population;Effectiveness;efficacious intervention;Ensure;Environment;Epidemic;Equity;ethnic disparity;Faculty;Funding;Gender;Geography;Health;health disparity;Health Policy;Health Services;Health system;HIV;HIV diagnosis;HIV disparities;HIV Infections;implementation intervention;implementation research;improved;Incidence;innovation;Institution;Interdisciplinary Study;Intervention Studies;Latinx;Leadership;Male Circumcision;Manuscripts;medical schools;men who have sex with men;Methods;mHealth;Mission;multidisciplinary;National Institute of Mental Health;next generation;novel;Outcome;Policy Research;prevent;Prevention;Prevention Research;Productivity;Prophylactic treatment;Public Health;Publishing;Race;racial disparity;Recording of previous events;Research;research and development;Research Design;Research Infrastructure;Research Personnel;Research Project Grants;Research Support;San Francisco;scale up;Science;Scientist;Services;Sex Orientation;social;social factors;Social Sciences;success;Technology;theories;tool;transgender men;transgender women;Translating;United States National Institutes of Health;uptake;Vulnerable Populations;young woman


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: LIGHTFOOT, MARGUERITA A. (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Administrative Efficiency;catalyst;Collaborations;Collection;Communities;community advisory board;community partners;Decision Making;design;Ensure;Environment;Ethics;experience;Fostering;Funding;Goals;Health system;HIV;Infrastructure;innovation;Institution;Interdisciplinary Study;International;Leadership;Learning;Mission;Monitor;operation;Organizational Culture;Organizational Productivity;poor health outcome;Population;Positioning Attribute;Prevention;Process;Productivity;Public Health;Research;Research Project Grants;research study;Research Support;Resources;response;scale up;Science;Scientific Advances and Accomplishments;Scientist;Strategic Planning;Structure;success;Sum;synergism;System;Systems Theory;transmission process;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Conditions Affecting the Embryonic and Fetal Periods;Infant Mortality;Lung;Maternal Health;Maternal Morbidity and Mortality;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative Nearly 2 million of the 3 million women who labor and deliver each year in the United States receive supplemental oxygen in labor in response to electronic fetal monitoring. Despite the theoretic goal of administering oxygen to the mother to improve fetal hypoxia and to prevent adverse neonatal outcomes or operative delivery for fetal concerns, there is no high quality evidence to support this practice. The proposed multicenter randomized trial has important public health implications because it will yield clinically applicable data for managing fetal monitoring during labor, minimizing neonatal morbidity among full-term infants and operative deliveries associated with short and long-term maternal morbidity.

PI_NAMEs: RAGHURAMAN, NANDINI  (contact)

PROGRAM_OFFICER_NAME: LONGO, MONICA

PROJECT_TERMS: Admission activity;Adult;adverse outcome;Air;American College of Obstetricians and Gynecologists;Apgar Score;arm;Blood;Categories;Cervical;Cesarean section;Clinical;clinical application;clinically relevant;Country;Data;data management;Dose;Effectiveness;Electronics;evidence base;evidence based guidelines;Exposure to;fetal;Fetal Heart Rate;Fetal Monitoring;Fetus;fetus hypoxia;Future;Gases;Geography;Goals;Hospitals;Hour;Hypoglycemia;Hypoxia;improved;in utero;Infant;Inferior;Intervention;intrapartum;Knowledge;maternal morbidity;maternal outcome;Measures;Meconium Aspiration;Meta-Analysis;Metabolic acidosis;Monitor;Morbidity - disease rate;mortality;Mothers;natural hypothermia;Neonatal;neonatal hypoxic-ischemic brain injury;Neonatal Intensive Care Units;neonatal morbidity;Neonatal Mortality;Neonatal Nursing;neonatal outcome;neonatal resuscitation;neonate;newborn wet lung disease;Obstetrical Nursing;Outcome;Oxygen;Oxygen Therapy Care;Patients;Pattern;Pediatrics;pilot trial;prevent;Protocols documentation;Public Health;Publishing;Pulmonary Hypertension;Randomized;randomized trial;Recommendation;recruit;Respiratory distress;response;Resuscitation;Retrospective cohort study;Risk;Seizures;Structure of umbilical artery;supplemental oxygen;Supplementation;Surrogate Markers;Testing;Time;trial comparing;United States;Vaginal delivery procedure;Woman;Women's Health;Work

PROJECT_TITLE: Maternal oxygen supplementation for Intrauterine Resuscitation: a Multicenter Randomized Trial

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-N(90)S]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: PROJECT NARRATIVE The proposed research is relevant to public health, because antibiotic resistance of bacterial pathogens is one of the greatest public health challenges of our time. As the emergence of resistance is outpacing the development of small-molecule antibiotics, this project aims to design new antimicrobial peptides against bacterial pathogens with innovative integration of computational, chemical, and biological approaches. These studies will provide a deeper understanding into the molecular mechanisms of antimicrobial peptides and provide new capacity to discover novel therapeutics to treat dangerous bacterial infections.

PI_NAMEs: LI, JIANING  (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Affect;analog;Animals;Anti-Bacterial Agents;anti-microbial peptide;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Antimicrobial Cationic Peptides;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;bacterial resistance;Binding;Biological;Biological Assay;Calorimetry;Cells;Cellular Assay;Characteristics;Chemicals;Clinic;combat;Communicable Diseases;Communities;Complex;Computational Technique;computerized tools;cost effective;Dangerousness;Data;design;Development;Drug resistance;drug resistant pathogen;Environment;experimental study;Extravasation;Failure;Fluorescence;Free Energy;Future;Generations;generative adversarial network;Goals;Growth;Healthcare;Homo;Infection;Innate Immune System;innovation;invention;Klebsiella pneumoniae;Knowledge;knowledge of results;large datasets;Learning;light scattering;lipid transport;Lipids;Machine Learning;magainin;Measurement;Membrane;membrane model;Methodology;Methods;Microbiology;Modernization;Molecular;multi-scale modeling;natural antimicrobial;network models;next generation;novel;novel therapeutics;pathogen;pathogenic bacteria;peptide structure;Peptide Synthesis;Peptides;Periplasmic Proteins;Plants;Process;Property;protein aminoacid sequence;Proteins;Public Health;Research;research and development;Resistance;Risk;simulation;small molecule;Structure;synergism;tachyplesin;Testing;Therapeutic;therapeutic target;Time;Titrations;tool;Toxic effect;Vesicle;Work

PROJECT_TITLE: Precision Design of Antimicrobial Peptides Against Bacterial Infections

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Infectious Diseases;Mental Health;Prevention

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Applications Grants;Area;Behavioral;Behavioral Research;Biomedical Research;burnout;career;catalyst;Clinical Research;cohesion;Collaborations;Communities;Competence;Creativeness;Development;Discipline;Effectiveness;Ensure;Environment;Epidemic;equity, diversity, and inclusion;Evaluation;Faculty;Fostering;Funding;Future;Goals;Grant;Growth;Health;Health system;HIV;Incubators;Individual;Influentials;innovation;Institution;Interdisciplinary Study;interest;Learning;Link;Manuscripts;Mentors;minority scientist;Mission;novel;Peer Review;Personal Satisfaction;Pilot Projects;Policy Maker;Positioning Attribute;prevent;Prevention;Productivity;programs;Public Health;Recording of previous events;Research;Research Personnel;Resources;Science;Scientific Advances and Accomplishments;Scientist;Services;skills;social;Strategic Planning;Structure;success;synergism;System;Time Management;Training;Training Programs;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Work;Writing

PROJECT_TITLE: Developmental Core


NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;HIV/AIDS;Infectious Diseases;Mental Health;Networking and Information Technology R&D (NITRD);Prevention

PI_NAMEs: NEILANDS, TORSTEN BRIAN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;advanced analytics;Affect;analytical method;Applications Grants;Area;behavior measurement;Big Data;Biological Markers;biomedical informatics;Caliber;Clinical;Collection;Communication;Communities;Complex;Consult;Consultations;Data;Data Analyses;Data Collection;data de-identification;data integration;Data Sources;data visualization;design;Disparity;Education;Educational workshop;effectiveness/implementation design;Electronic Health Record;Emerging Technologies;Ensure;Epidemic;Extramural Activities;Fostering;Health;health care delivery;Health system;HIV;improved;Individual;Interdisciplinary Study;Intervention;Joints;Journals;Machine Learning;Manuscripts;Measures;Methods;Mission;Modernization;multiple data sources;Natural Language Processing;Participant;Peer Review;Peer Review Grants;personalized medicine;poor health outcome;pragmatic implementation;preservation;Prevention;Problem Solving;Reporting;Research;Research Design;Research Methodology;Research Personnel;Research Project Grants;response;Risk;Sample Size;Scientific Advances and Accomplishments;Scientist;sensor;Services;social media;Source;Structure;symposium;systems research;Technology;tool;Training;United States National Institutes of Health

PROJECT_TITLE: Research Project: Methods Core


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Childhood Injury;Clinical Research;Data Science;Emergency Care;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Precision Medicine;Prevention;Suicide;Suicide Prevention;Violence Research;Youth Violence;Youth Violence Prevention

ORG_CITY: LOS ANGELES

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Suicide is the second leading cause of death among U.S. children: suicide attempts are common, costly, and preventable, and reduction in youth suicide is a national and international priority area. Computational approaches to predict risk of future suicide attempts using medical records have emerged as a promising means to address the crisis of youth suicide by identifying children who could benefit from early, evidence- based intervention before suicidal behavior occurs or escalates. This study seeks to improve detection and prediction of emergency department visits for suicide attempts among children aged 10 to 17 by newly adapting a computational method applied to existing medical records (electronic health record phenotyping), and then assessing the perceived added clinical benefit of an electronic health record-integrated personalized risk prediction software prototype among potential end users.

PI_NAMEs: EDGCOMB, JULIET BENI (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: 10 year old;17 year old;Achievement;Address;Adolescent;Adolescent Psychiatry;Advocate;Age;aged;Algorithms;Area;blind;California;career development;Caring;case control;Cause of Death;Characteristics;Child;Child Psychiatry;Classification;Clinical;Clinical Data;Clinical Informatics;Code;comorbidity;Computer software;Computing Methodologies;cost;Data;Data Set;Decision Making;demographics;design;Detection;detection method;Development;Diagnosis;Diagnostic;Discipline;Disease;Early Diagnosis;Electronic Health Record;Emergency Care;Emergency department visit;Ethnic Origin;evidence base;Evidence based intervention;experience;Face;Family;Family member;Future;Goals;gradient boosting;health care settings;Health Care Visit;health inequalities;Health system;improved;indexing;Individual;Informatics;Insurance;International;Knowledge;Lasso;Lived experience;Los Angeles;Machine Learning;machine learning classifier;Manuals;Medical;Medical Records;medical specialties;member;Mental Health;Methods;Modeling;multidisciplinary;National Institute of Mental Health;natural language;Natural Language Processing;Natural Language Processing pipeline;Performance;personalized approach;personalized medicine;personalized risk prediction;Persons;Phenotype;point of care;pre-trained transformer;predictive modeling;Predictive text;predictive tools;Predictive Value;Prevention;Prevention approach;prospective;prototype;Provider;Public Health;Qualitative Research;Race;random forest;Recording of previous events;Research;Research Personnel;responsible research conduct;Risk;risk prediction;risk prediction model;sex;Signal Transduction;simulation;Site;skills;Social Psychology;sociodemographics;Standardization;Structure;Subgroup;suicidal adolescent;suicidal behavior;suicidal risk;Suicide;Suicide attempt;Suicide prevention;support vector machine;Text;Time;timeline;tool;Training;Training Programs;Translating;United States;Universities;usability;Validation;Variant;Visit;young adult;Youth

PROJECT_TITLE: Electronic Health Record Phenotyping for Case Detection and Prediction of Emergency Department Visits for Child and Adolescent Suicide Attempts

STUDY_SECTION: CDMA

STUDY_SECTION_NAME: Clinical Data Management and Analysis Study Section[CDMA]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention

PI_NAMEs: REBCHOOK, GREGORY MICHAEL (contact)

PROJECT_TERMS: Acceleration;Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;base;Caring;Clinic;Clinical;Collaborations;Communities;community advisory board;community engaged approach;community engaged research;community engagement;Community Health Systems;community organizations;Community Participation;community research;Community Services;design;empowerment;Ensure;Epidemic;Equity;evidence base;experience;Fostering;Government;Health;health disparity;Health Personnel;Health Policy;Health system;HIV;Human Resources;improved;innovation;International;member;Methods;Mission;Personal Satisfaction;Persons;Phase;Policies;Policy Maker;Population;Prevention;Prevention Research;Process;programs;Public Health;Research;Research Personnel;Research Project Grants;Science;Scientific Advances and Accomplishments;Scientist;service providers;Service setting;theories;Training;Translating;translational approach;United States National Institutes of Health

PROJECT_TITLE: Research Project: Community Engagement Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: LIPPMAN, SHERI ANN (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS prevention;Automobile Driving;Behavioral;Belief;care systems;Caring;Client;Clinical;Collaborations;Communities;community based care;community setting;Complex;condoms;Consultations;Data;data integration;design;Disparity;Dissemination and Implementation;Educational workshop;effective intervention;efficacious intervention;empowerment;Ensure;Epidemic;Equity;Evidence based intervention;experience;Fostering;Gender;Grant Review;Health;health assessment;health care delivery;Health care facility;health disparity;Health Services;Health Services Accessibility;Health system;HIV;HIV Infections;Home;Housing;implementation framework;implementation intervention;implementation process;implementation science;implementation strategy;improved;Inequity;innovation;Intervention;intervention delivery;Leadership;Learning;lens;Location;Male Circumcision;Measurement;meetings;Methodology;Mission;Monitor;multidisciplinary;novel strategies;nutrition;Outcome;patient navigation;Peer Review;person centered;Personal Satisfaction;Policies;Population;pre-exposure prophylaxis;prevent;Prevention;Primary Prevention;programs;Research;Research Project Grants;Research Support;response;routine practice;Science;Scientific Advances and Accomplishments;Scientist;Secondary Prevention;Services;Shapes;skills;Social Conditions;social structure;symposium;System;systems research;theories;therapy development;tool;Training;Translating;vulnerable community;Work

PROJECT_TITLE: Research Project: Implementation Science and Health Services Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Genetics;Human Genome;Sleep Research

ORG_CITY: PULLMAN

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: WASHINGTON STATE UNIVERSITY

ORG_STATE: WA

PHR: Sleep is an extremely conserved drive across the animal kingdom, but its function remains a mystery. We hypothesize that one of the evolutionary conserved functions of sleep is to influence gene expression and chromatin regulation. This proposal will utilize state of the art single-cell genomic technology to define, for the first time, sleep-dependent transcriptional and epigenetic programs conserved between two distantly related vertebrate species: Mouse and Zebrafish.

PI_NAMEs: PEIXOTO, LUCIA  (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Animals;Architecture;Atlases;Award;Behavior;behavior change;Brain;cell type;Cells;Chromatin;comparative genomics;Complex;Computational Biology;Computer software;Data Analyses;Distant;DNA;Doctor of Philosophy;Epigenetic Process;epigenomics;Evolution;experience;Fellowship;Gene Expression;Gene Expression Regulation;Genetic Transcription;Goals;Longitudinal Studies;Maps;Messenger RNA;Mus;Organism;Postdoctoral Fellow;Process;programs;Protein Biosynthesis;Proteins;Regulation;Research;Research Personnel;Resolution;response;Role;single cell genomics;Sleep;Sleep Deprivation;Technology;Time;Tissues;Training;Transcriptional Regulation;transcriptomics;Zebrafish

PROJECT_TITLE: The role of sleep on chromatin and transcriptional regulation across vertebrate evolution.

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ADMINISTERING_IC: CA

ED_INST_TYPE: SCHOOLS OF NURSING

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Prevention

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

PHR: Project Narrative Building on our history of training cancer prevention and control researchers, we are submitting a competing continuation of “Interdisciplinary Training in Cancer Prevention and Control”. Our competing continuation focuses on recruitment of diverse trainees who are supported by a training program integrating all aspects of cancer health disparities.

PI_NAMEs: CHAMPION, VICTORIA LEE (contact);MOSHER, CATHERINE E

PROGRAM_OFFICER_NAME: DAMICO, MARK W

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Cardiovascular;Clinical Research;Data Science;Emergency Care;Health Services;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Prevention

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE In managed long-term care, care coordinators (i.e., registered nurses and social workers) periodically communicate with the patients over the telephone to ensure that they receive care congruent with the patient’s health needs. These verbal communications between patients with heart failure and care coordinators may include clues on risk factors for hospitalizations and emergency department visits. With cutting-edge artificial intelligence techniques, this project aims to examine whether audio-recorded verbal telephone communication (i.e., verbal communication) can be analyzed and utilized to improve risk prediction.

PI_NAMEs: SONG, JIYOUN  (contact)

PROGRAM_OFFICER_NAME: WANG, WAYNE C

PROJECT_TERMS: Accident and Emergency department;Acoustics;Address;Affect;Algorithms;Area;Artificial Intelligence;Award;Behavior;Blood;Cardiac;Cardiomegaly;care coordination;care systems;career;Caring;Characteristics;Clinical;Clinical Decision Support Systems;Code;Communication;Communities;Data Science;Data Set;Data Sources;data streams;deep learning model;design;Deterioration;Diagnostic;dual eligible;Early identification;Electronic Health Record;electronic structure;Emergency department visit;Emotional;ethnic diversity;Event;Family;frontier;Goals;Health;Health Care Costs;health care service organization;Health Expenditures;Health Personnel;Healthcare;Heart;Heart failure;Home Care Services;Hospitalization;Hospitals;improved;Infection;insight;Language;Laryngeal Nerves;Linguistics;Liquid substance;Long-Term Care;Lung;Machine Learning;machine learning algorithm;Medical;Medicare/Medicaid;Mentorship;Modeling;National Heart, Lung, and Blood Institute;Nerve compression syndrome;Nursing Homes;Nursing Services;older adult;Outcome;Pathway interactions;Patient Care;Patients;Pattern;payment;Performance;Phase;Phenotype;phrases;post-doctoral training;Postdoctoral Fellow;pre-doctoral;prevent;programs;Quality of Care;racial diversity;Registered nurse;Research;Risk;Risk Factors;risk prediction;risk prediction model;Roter;Self Management;Signal Transduction;Sleep;Social Workers;Speech;Strategic vision;Structure;structured data;Swelling;Symptoms;Systems Analysis;Techniques;Telephone;telephone delivery;Testing;Training;unstructured data;verbal;Visiting Nurse;Voice

PROJECT_TITLE: HEAR-HEARTFELT (Identifying the risk of Hospitalizations or Emergency depARtment visits for patients with HEART Failure in managed long-term care through vErbaL communicaTion)

STUDY_SECTION: MTI

STUDY_SECTION_NAME: NHLBI Mentored Transition to Independence Study Section[MTI(MA)]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Chronic Pain;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative New technologies, methods and models are needed to advance our scientific understanding of how the nervous system maintains the surface of the eye. We will apply several new technologies, animal models, and methods to study molecular, cellular, and functional interactions across the surface of the eye and regions controlling it. We will compare how these interactions change under inflammatory and pain conditions.

PI_NAMEs: JENKINS, MICHAEL W. (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: 3-Dimensional;adaptive immunity;Address;Animal Model;Behavior;blink reflexes;Brain;Brain region;Calcium;cell type;Cells;Chemicals;chemokine;Cornea;Custom;cytokine;data visualization;Debridement;deep learning;density;Diabetic mouse;Disabling;Disease;Dry Eye Syndromes;Dyes;Electrophysiology (science);Environment;Epithelium;Equilibrium;Esthesia;Eye;Eyelid structure;Feedback;Film;Fluorescent in Situ Hybridization;Functional disorder;Functional Imaging;Ganglia;Gland;Goblet Cells;Homeostasis;Human;Image;Image Analysis;Immune;Immune response;Immunology;Implant;Implanted Electrodes;Inflammation;Inflammatory;interest;Ion Channel;Keratitis;Knowledge;Lacrimal gland structure;Light;lipid metabolism;lipophilicity;Measures;Mechanics;Medial;meibomian gland;Methods;Microscopy;Modeling;Molecular;Morphology;mouse model;multi-electrode arrays;Mus;Natural Immunity;Nerve;Nerve Growth Factors;Nervous System;neural;neuroimaging;Neurons;neuroregulation;Neurosciences;new technology;Nociception;ocular surface;ocular surface disease;Optics;Organ;Organism;Pain;Pain Clinics;painful neuropathy;Pathologic;Pattern;Peripheral Nervous System Diseases;preservation;Production;Pseudomonas aeruginosa;receptor;response;response to injury;sensory feedback;Signal Induction;statistics;Stimulus;Structure;Structure of trigeminal ganglion;Supporting Cell;Surface;System;technology/technique;Thalamic structure;Tissues;tool;Trigeminal System;Visualization;Work

PROJECT_TITLE: Understanding neural control of the ocular surface


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Narrative The Cancer Research Scholars Program (CRSP) will equip outstanding undergraduate students with research skills applicable across the cancer continuum, as well as skills in professionalism, cultural competence and team science that will enable them to thrive in cutting-edge cancer research graduate programs and cancer career pathways. By creating and engaging faculty as part of CRSP's Cancer Mentor Network in our innovative educational and underserved, communityengaged field experiences, we will empower future collaboration between scholars and mentors across the cancer continuum and encourage mutually beneficial community outreach and community-tailored education activities that will meaningfully inform and inspire their future research choices.

PI_NAMEs: BUTSCHKOVACIC, MELINDA SUE (contact)

PROGRAM_OFFICER_NAME: RADAEV, SERGEY

PROJECT_TERMS: Academia;Address;Adopted;African American;anti-cancer research;Attention;Basic Science;Breast;Bronchi;Cancer Biology;cancer care;Cancer Center;cancer education;Cancer Etiology;Cancer Patient;cancer prevention;Cancer Survivorship;career;Career Choice;Caring;Cause of Death;cervical and uterine cancer;Cessation of life;Clinical;cohort;Collaborations;Colon;Communication;Communities;community engaged research;Community Networks;Community Outreach;Counseling;Critical Thinking;cultural competence;Cultural Diversity;Dangerousness;Dedications;Development;Discipline;Discipline of Nursing;Disparity;early screening;Education;Education and Outreach;Educational Activities;Educational workshop;empowerment;Ensure;Environmental Health;Evaluation;Event;experience;Faculty;faculty mentor;Fellowship Program;First Generation College Students;Foundations;Funding;Future;Generations;Goals;graduate student;Grief reaction;Health;health determinants;health inequalities;Health Professional;Health Promotion;Healthcare;Human;implicit bias;improved;Inequity;Infrastructure;innovation;interest;Internships;Investments;Laboratories;Lead;Learning;Life;Lung;Malignant Neoplasms;Medical center;Medicine;member;men;Mentors;microaggression;minority health;mortality;notch protein;nutrition;Ohio;Oral;Pancreas;patient navigator;patient population;Pediatric Hospitals;Persons;Play;Population;Postbaccalaureate;Postdoctoral Fellow;Prevention;Process;programs;Prostate;Public Health;Qualifying;Race;recruit;Rectum;Recurrence;Reduce health disparities;Reporting;Research;Research Design;Research Personnel;Research Training;responsible research conduct;Scholars Program;Science;screening;Self Efficacy;senior faculty;Services;skills;social;Social Environment;social health determinants;socioeconomics;sound;Students;success;summer internship;supportive environment;Surveys;Survivors;survivorship;System;Testing;Time;Training;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Minority;underserved community;United States;United States Dept. of Health and Human Services;United States National Academy of Sciences;Universities;Vulnerable Populations;Work;Writing

PROJECT_TITLE: The Cancer Research Scholars Program (CRSP): Exploring Research Across the Cancer Continuum and into Underserved Communities


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Dissemination and Implementation Research;HIV/AIDS;Health Services;Infectious Diseases;Prevention

ORG_CITY: LUSAKA

ORG_COUNTRY: ZAMBIA

ORG_FIPS: ZA

ORG_NAME: CENTRE FOR INFECTIOUS DISEASE RESEARCH

PHR: PROJECT NARRATIVE This study aims to apply empirically supported implementation science strategies, including task shifting, audit and feedback, and eHealth clinical decision support to integrate management of cardiovascular disease risk factors and cardiometabolic complications of HIV within a robust HIV service delivery platform in Lusaka, Zambia. We will use established implementation science theories, strategies, and constructs to implement an adapted version of the evidence-based WHO Package of essential noncommunicable disease interventions (WHO PEN) using non-physician health workers, and rigorously evaluate the intervention using a pragmatic, stepped-wedged trial design.

PI_NAMEs: HERCE, MICHAEL EMMANUEL;MUTALE, WILBROAD  (contact)

PROGRAM_OFFICER_NAME: MINTZER, KEITH A

PROJECT_TERMS: Acceleration;Address;Adverse effects;Advocate;Africa South of the Sahara;Algorithms;Anti-HIV Agents;Anti-Retroviral Agents;antiretroviral therapy;burden of illness;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Caring;Chronic;Clinic;Clinical;clinical decision support;Clinical effectiveness;Coin;Community Health Aides;comorbidity;Complex;Complication;cost;cost effective;cost effectiveness;Cost Effectiveness Analysis;Counseling;Data;Data Collection;Data Science;design;Detection;Diabetes Mellitus;Disease;disorder risk;Dyslipidemias;Effectiveness;effectiveness evaluation;effectiveness/implementation hybrid;eHealth;Eligibility Determination;Epidemic;Equipment;evidence base;Evidence based intervention;experience;Feedback;Focus Groups;Funding;Future;Genetic;Guidelines;Health;Health Personnel;Health Professional;Health system;Healthcare;HIV;HIV Seropositivity;Human Resources;Hybrids;Hypertension;implementation evaluation;implementation framework;implementation outcomes;implementation science;implementation strategy;implementation/effectiveness;improved;Individual;Infection;Interactive Systems Framework;Intervention;Interview;Investments;Knowledge;Lead;Life Style;low and middle-income countries;Malignant Neoplasms;Maternal and Child Health;Measurement;Measures;Mental Health;Metabolic;Modeling;modifiable risk;Modification;Morbidity - disease rate;mortality;multidisciplinary;novel;Nurses;Nursing Services;Opportunistic Infections;Outcome;pandemic disease;Participant;Patients;personalized management;Persons;Pharmaceutical Preparations;Pharmacotherapy;Phase;Physicians;Pilot Projects;prevent;Primary Care;Primary Prevention;Productivity;programs;Protocols documentation;Quality of life;Quasi-experiment;Randomized;Recommendation;Research;Resources;Risk;Risk Factors;routine care;scale up;screening;secondary endpoint;Secondary Prevention;Self Management;service delivery;skills;standard of care;stem;support tools;synergism;systemic inflammatory response;task analysis;theories;Tobacco use;Training;Training Support;treatment guidelines;Treatment Protocols;trial design;United States National Institutes of Health;Viral;Viral Load result;virtual;Zambia

PROJECT_TITLE: Application of Implementation Science approaches to assess the effectiveness of Task-shifted WHO-PEN to address cardio metabolic complications in people living with HIV in Zambia


NIH_SPENDING_CATS: Biotechnology;Clinical Research

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: The complement system is an ancient immune defense system in animals and humans. To date, little is understood about the differences in the complement systems of various species. In this proposal, we will seek to understand biologic basis of complement activity among different species.

PI_NAMEs: AREPALLY, GOWTHAMI M (contact)

PROGRAM_OFFICER_NAME: JOFFE, AARON MICHAEL

PROJECT_TERMS: Address;Animal Model;Animals;Antibodies;Antigen-Antibody Complex;Autoimmune;Binding;Biological;Cavia;Classical Complement Pathway;Clinical;Cold Hemagglutinin Disease;Comparative Study;Complement;Complement 3 Convertase;Complement 3b;Complement 3c;Complement Activation;Complement Inactivators;complement pathway;complement system;Complex;Data;Development;differential expression;Dinitrophenols;Disease;Erythrocytes;Feedback;Funding;Future;Generations;Genetic;Genetic Variation;Genomics;Goals;Graft Rejection;Hemolysis;Hemolytic-Uremic Syndrome;Heparin;hereditary angioneurotic edema;Human;Immune;Immunological Models;Impairment;inhibitor;Keyhole Limpet Hemocyanin;Laboratory Animals;Malignant Neoplasms;Mediating;Medical;Molecular;Monoclonal Antibodies;mouse model;Mus;Mutation;Oryctolagus cuniculus;paroxysmal nocturnal hemoglobinuria;Pathway interactions;PF4 Gene;Physiological;Plasma;Proteins;Proteome;Proteomics;Publishing;Rattus;research and development;response;Serum;species difference;Study models;success;System;Testing;Therapeutic;therapeutic evaluation;Variant;Whole Blood

PROJECT_TITLE: Comparative studies of complement responses to ICs

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Acute Respiratory Distress Syndrome;Clinical Research;Hematology;Lung;Orphan Drug;Precision Medicine;Prevention;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE Bone marrow transplantation can cure many cancers, blood disorders and metabolic or genetic diseases; however, it can be accompanied by life-threatening pulmonary complications. Respiratory failure can be extremely severe, carries a mortality rate up to 60%, and has little directed treatment outside of supportive care. We propose to study a novel method to predict which patients are at the highest risk to develop respiratory failure using objective biomarkers that may allow for early identification of risk, development of new drugs for respiratory failure based on the biologic pathways identified with biomarkers, and ultimately targeted therapies to prevent the occurrence of respiratory failure.

PI_NAMEs: ROWAN, COURTNEY  (contact)

PROGRAM_OFFICER_NAME: LACHOWICZ-SCROGGINS, MARRAH ELIZABETH

PROJECT_TERMS: Acute Respiratory Distress Syndrome;Acute respiratory failure;Adult;Allogenic;Appearance;Award;Biological;Biological Assay;Biological Markers;biomarker development;biomarker panel;biomarker validation;Blood Tests;Bone Marrow Transplantation;candidate marker;career;career development;Caring;Child;Clinical;clinical biomarkers;clinical practice;Clinical Research;Clinical Trials;cohort;Complication;Critical Illness;Data;Death Rate;design;Development;Development Plans;Diagnostic;Disease;Distress;Early identification;Early Intervention;Etiology;Event;experience;Foundations;Funding;Future;Genetic Diseases;Goals;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hospitalization;Idiopathic pneumonia syndrome;implementation science;improved;Incidence;Indiana;innovation;interest;Interleukin-6;Intubation;Kinetics;Knowledge;Life;Lung;Malignant - descriptor;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Medical;medical schools;Mentors;Mentorship;Metabolic Diseases;Methods;Modeling;Monitor;mortality;Multicenter Studies;Non-Malignant;novel;novel strategies;novel therapeutics;Pathway interactions;Patients;pediatric patients;personalized medicine;Phase;Plasma;Population;Positioning Attribute;power analysis;preemptive intervention;prevent;Prevention;Prognosis;prognostic;Prognostic Marker;prognostic model;prognostic value;prospective;Prospective Studies;Proteins;Proteomics;receptor;Research;research study;Respiratory Failure;Respiratory Signs and Symptoms;Risk;Sampling;skills;Statistical Methods;Supportive care;tandem mass spectrometry;targeted treatment;Testing;Time;TNFRSF1A gene;Training;Translating;Translational Research;Transplant Recipients;United States National Institutes of Health;Universities;Validation;Work

PROJECT_TITLE: Prognostic biomarkers for respiratory failure post hematopoietic cell transplantation

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR(MA)]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: STANFORD

ORG_DEPT: GENETICS

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative We propose a Center Without Walls focused on deciphering the mechanisms of the neurodegenerative disease FTLD-TDP. We have brought together experts in neurology, human genetics, pathology, and genomics to focus intensely on an exciting new role of cryptic exon splicing as a key driver of neurodegeneration. We have discovered dozens of novel cryptic exon splicing events in FTLD-TDP and these will inform disease mechanisms, serve as sensitive biomarkers, and point to new therapeutic targets for this devastating human disease.

PI_NAMEs: FRATTA, PIETRO ;GITLER, AARON D. (contact);PETRUCELLI, LEONARD ;PRUDENCIO, MERCEDES ;RAJ, TOWFIQUE ;SEELEY, WILLIAM W

PROGRAM_OFFICER_NAME: SHEWMAKER, FRANK PAUL

PROJECT_TERMS: Addendum;alpha synuclein;Alzheimer's Disease;Amyloid beta-Protein;Antibodies;Antigens;Biochemical;Biological Markers;Biological Models;Brain;Brain Diseases;Brain region;Cell Nucleus;Code;Communities;Cytomegalovirus Infections;Cytoplasm;Data;Dedications;Disease;disease classification;empowerment;Event;Exons;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;gain of function;Genes;Genetic;genetic risk factor;Genomics;Goals;high resolution imaging;Human;human disease;Human Genetics;human imaging;human tissue;innovation;Link;Messenger RNA;Methods;misfolded protein;Molecular Weight;Monoclonal Antibodies;multimodality;Mutation;Names;Nerve Degeneration;Neurodegenerative Disorders;Neurology;Neurosciences;new therapeutic target;novel;Nuclear;Nuclear Protein;Parkinson Disease;Pathogenesis;Pathogenicity;Pathologic;Pathology;polyglutamine;Prion Diseases;Process;programs;protein aggregation;protein TDP-43;Proteins;PrP;Research;Resolution;Resources;RNA metabolism;RNA Splicing;RNA Transport;RNA-Binding Proteins;Role;Sagittaria;specific biomarkers;tau Proteins;TDP-43 aggregation;Testing;therapeutic target;Toxic effect;transcriptome sequencing;Ubiquitin;Virginia;Vision;web portal

PROJECT_TITLE: Discovery of novel TDP-43 splicing targets: the Achilles heel for FTD and towards sensitive biomarkers and therapeutic targets


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Amyotrophic Lateral Sclerosis (ALS);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

PI_NAMEs: GITLER, AARON D. (contact)

PROJECT_TERMS: Achievement;Addendum;Advisory Committees;Autopsy;Biological Markers;Biological Models;Brain;Brain region;brain tissue;Cell Nucleus;Code;Collaborations;Communication;Communities;Data;data communication;data sharing;Decision Making;Dedications;Disease;Doctor of Philosophy;Electronic Mail;empowerment;Ensure;Event;Exons;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Genetic;genetic risk factor;Genomics;Geographic Locations;Goals;Grant;Health;high resolution imaging;Human;Human Genetics;human imaging;Human Resources;human tissue;Induced pluripotent stem cell derived neurons;innovation;Manuscripts;meetings;Methods;Modeling;Monitor;multimodality;National Institute of Neurological Disorders and Stroke;Nerve Degeneration;Neurology;Neurosciences;novel;operation;Pathology;Persons;Process;programs;protein TDP-43;Reporting;Research;Research Personnel;Research Project Grants;Resolution;Resources;RNA Splicing;Schedule;specific biomarkers;Teleconferences;Telephone;Testing;therapeutic target;transcriptome sequencing;transcriptomics;Universities;Vision;web portal


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences;Orphan Drug;Prevention;Rare Diseases

PI_NAMEs: RAJ, TOWFIQUE  (contact)

PROJECT_TERMS: Addendum;Affect;Age of Onset;Alzheimer's Disease;Biological Markers;Biological Models;biomarker discovery;Brain;Brain Pathology;Brain region;brain tissue;C9ORF72;Cell model;Cell Nucleus;cell type;Cells;Code;Communities;Computational Technique;Cytoplasm;Data;Dedications;dementia risk;derepression;design verification;Disease;Dissociation;DNA Sequence Alteration;Doctor of Philosophy;empowerment;Event;Exons;experimental study;Freezing;frontal lobe;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Genes;Genetic;genetic risk factor;genetic variant;genome wide association study;genomic data;genomic locus;Genomics;Goals;high resolution imaging;Human;Human Genetics;human imaging;human tissue;Individual;innovation;insight;knock-down;Length;Link;Maps;Measures;medical schools;Messenger RNA;Meta-Analysis;Metabolism;Methods;Molecular;mRNA Precursor;multimodality;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neurology;Neurons;Neurosciences;Nonsense-Mediated Decay;novel;Nuclear;Nuclear Export;Pathologic;Pathology;Patients;Polyadenylation;Population;premature;Process;programs;protein TDP-43;Research;Research Project Grants;Resolution;Resources;response;Risk;risk variant;RNA Splicing;RNA-Binding Proteins;Sampling;single-cell RNA sequencing;specific biomarkers;Specificity;TDP-43 aggregation;Temporal Lobe;Testing;therapeutic target;Transcript;transcriptome sequencing;Vision;web portal;Work

PROJECT_TITLE: Genomics Core


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Gene Therapy;Gene Therapy Clinical Trials;Genetics;Hematology;Immunotherapy;Infectious Diseases;Lymphatic Research;Lymphoma;Orphan Drug;Patient Safety;Prevention;Rare Diseases

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: PROJECT NARRATIVE People receiving chimeric antigen receptor T cell therapy (CARTx) for cancer treatment are often given immunoglobulin G (IgG) replacement therapy (IGRT) to prevent infections; however, no data support this practice in this patient population, and IGRT requires careful stewardship given national shortages, potential side effects, and high expense. To establish the risks and benefits of this frequently used infection-prevention strategy, we will conduct a randomized, placebo-controlled trial of IGRT in CARTx patients. We will compare infection rates, antibody levels, health resource utilization, and CAR-T cell kinetics and function among participants who do and do not receive IGRT to establish evidence-based data to guide the use of IGRT in the rapidly growing population of CARTx recipients.

PI_NAMEs: HILL, JOSHUA AIDEN (contact);PERALES, MIGUEL-ANGEL

PROGRAM_OFFICER_NAME: EMENAKER, NANCY J

PROJECT_TERMS: Accounting;Adoptive Immunotherapy;Adult;Adverse event;Affect;Antibiotics;Antibodies;arm;B lymphoid malignancy;Bacterial Infections;Benefits and Risks;Blood;cancer therapy;CAR T cell therapy;Caring;CD19 gene;Cell Cycle Kinetics;Cell Physiology;Cell Surface Proteins;Cells;Cessation of life;chimeric antigen receptor T cells;Clinical;clinical efficacy;clinical risk;Communicable Diseases;Controlled Study;cost;Cox Models;cytokine release syndrome;Cytometry;Data;design;dimensional analysis;Disease remission;Double-Blind Method;Dropout;Emergency department visit;Ensure;Equity;evidence base;follow-up;Future;Health Resources;Healthcare;High Prevalence;Hospitalization;Humoral Immunities;hypogammaglobulinemia;Image;Immune;immune effector cell-associated neurotoxicity syndrome;immune reconstitution;Immunoglobulin G;Immunoglobulins;Immunooncology;Incidence;Infection;Infection prevention;infection rate;infection risk;Infusion procedures;insight;Intention;Kinetics;Life;Lymphoma;Malignant Neoplasms;Measures;Medical;Medical Records;neurotoxicity;Outcome;Outcomes Research;Outpatients;Participant;pathogen;patient population;Patients;Persons;Pharmaceutical Preparations;Physicians;placebo controlled study;Placebos;Population;Prevention strategy;Progression-Free Survivals;prophylactic;radiological imaging;Randomized;randomized placebo controlled trial;randomized trial;randomized, controlled study;Randomized, Controlled Trials;Recovery;Replacement Therapy;Resolution;Resources;Risk;Scientist;Serum;Severities;side effect;Signal Transduction;Site;Streptococcus pneumoniae;Subgroup;Toxic effect;tumor;Visit

PROJECT_TITLE: Immunoglobulin Replacement Therapy and Infectious Complications After CD19-Targeted CAR-T-Cell Therapy

STUDY_SECTION: CONC

STUDY_SECTION_NAME: Clinical Oncology Study Section[CONC]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Despite many years of research that have focused almost exclusively on patient-level barriers to care (despite the importance of positive patient-provider relationships in HIV care engagement), there are still significant gaps in the number of persons living with HIV (PLWH) who are fully engaged in care, making the HIV epidemic difficult to control. Nurses who provide care in the public sector in South Africa (SA) are the frontline providers of HIV care and experience extremely high levels of stress as a consequence of limited resources, hindering their ability to provide effective care, a situation that has been exacerbated by the ongoing COVID-19 pandemic. This study will tailor an established stress management and resilience-enhancing intervention to meet the needs and improve the well-being of nurses providing HIV care in the public sector in SA, and then evaluate the feasibility and acceptability of our program, with the goal of developing a scalable intervention that could be used across similar settings worldwide to improve the treatment and care of PLWH.

PI_NAMEs: PSAROS, CHRISTINA  (contact)

PROJECT_TERMS: acceptability and feasibility;Address;Adherence;Adult;Affect;Age;American;Attitude;barrier to care;Behavior;burnout;Care given by nurses;Caring;Chronic;Client satisfaction;Clinic;clinically relevant;Communication;coping;Coping Skills;COVID-19 pandemic;Data;Discipline of Nursing;Educational process of instructing;efficacy trial;Elements;Eligibility Determination;Empathy;Enrollment;Epidemic;Evaluation;experience;feasibility testing;Feedback;Focus Groups;Fostering;Goals;Health;Health Personnel;Healthcare Systems;Highly Active Antiretroviral Therapy;HIV;Home;Hospitalization;Human immunodeficiency virus test;Hybrids;Immunity;improved;Individual;interpersonal conflict;Intervention;Interview;Length;Measures;Medical;member;migration;Nurses;Occupational;occupational stress;Occupations;Outcome;Participant;Patient Self-Report;Patient-Focused Outcomes;patient-level barriers;Patients;Perception;Personal Satisfaction;Persons;premature;Prevalence;Prevention;Procedures;programs;promote resilience;Protocols documentation;Provider;Province;Psychology;Public Health;Public Sector;Randomized;Recovery;Relaxation;Research;resilience;Resource-limited setting;Resources;response;SARS-CoV-2 B.1.351;satisfaction;shift work;Shoulder;Site;skills;social stigma;Source;South Africa;Stress;stress management;stress reduction;stress resilience;stressor;testing uptake;therapy development;Time;Trauma;Trust;Vertical Disease Transmission;Viral;Viral Load result;virtual;Wages;Work;World Health

PROJECT_TITLE: Developing a resiliency intervention to support healthcare workers engaged in the provision of HIV care

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


PI_NAMEs: PETRUCELLI, LEONARD  (contact)

PROJECT_TERMS: Addendum;Age;Antibodies;Autopsy;Biological Assay;Biological Markers;Biological Models;biomarker development;biomarker panel;Brain;Brain region;brain tissue;candidate marker;Cell Nucleus;Cells;Cerebrospinal Fluid;Characteristics;Clinic;Clinical;Code;Collaborations;Communities;cryptic protein;Data;Data Set;Dedications;design;Detection;Diagnostic;diagnostic biomarker;Disease;Disease Progression;Doctor of Philosophy;empowerment;Ensure;Evaluation;Event;Exons;Frontotemporal Dementia;Frontotemporal Lobar Degenerations;Functional disorder;Genetic;genetic risk factor;Genomics;Goals;high resolution imaging;Human;Human Genetics;human imaging;human tissue;Immunoassay;Induced pluripotent stem cell derived neurons;innovation;insight;Light;Measures;Methods;Mining;Monitor;multimodality;Nature;Nerve Degeneration;neurofilament;Neurology;Neurosciences;novel;Onset of illness;Pathogenesis;Pathology;Patients;Peptides;Phosphorylation;Plasma;Process;Production;prognostic;Prognostic Marker;prognostic value;Program Development;programs;Protein Isoforms;protein TDP-43;Proteins;Proxy;Research;research and development;Research Project Grants;Resolution;Resources;RNA;RNA Splicing;Role;Sampling;Severity of illness;specific biomarkers;Specificity;stathmin;Surrogate Markers;Testing;therapeutic development;therapeutic target;Time;Tissue Sample;Tissues;tool;Transcript;transcriptome sequencing;Translating;Validation;Variant;Vision;web portal;Work

PROJECT_TITLE: Human Biomarkers Core


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Breast Cancer;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Dissemination and Implementation Research;Health Services;Nutrition;Patient Safety;Physical Activity;Physical Rehabilitation;Prevention;Rehabilitation;Telehealth;Women's Health Research

ORG_CITY: PITTSBURGH

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Older women have worse outcomes from breast cancer treatment, in part due to under treatment and toxicities. Exercise and protein intake support, in combination, are a promising intervention to improve these outcomes. We propose a randomized controlled trial to assess the effects of a multicomponent, hybrid telehealth (TH) exercise and protein intake support (the THRIVE Intervention) on received dose intensity, incidence and severity of chemotoxicities, functional status, muscle mass, and patient reported outcomes in 270 breast cancer patients age ≥ 65 receiving neo/adjuvant chemotherapy.

PI_NAMEs: LIGIBEL, JENNIFER A.;SCHMITZ, KATHRYN H. (contact)

PROGRAM_OFFICER_NAME: GREENBERG, DEBORAH B

PROJECT_TERMS: Adherence;Adjuvant Chemotherapy;Administrator;Age;Attenuated;behavior change;Body Weight decreased;breast cancer diagnosis;Breast Cancer Patient;Breast Cancer Treatment;Cancer Patient;cancer therapy;Caring;Certification;chemotherapy;clinical practice;Control Groups;cost;Data;Diagnosis;Diet;Dietitian;Disease Outcome;disorder risk;Dose;Dose Limiting;Effectiveness of Interventions;efficacy evaluation;Elderly;Elements;Etiology;Evaluation;Exercise;exercise intervention;experience;falls;Fatigue;functional status;General Population;Geriatric Assessment;Health education;human old age (65+);Human Resources;Hybrids;implementation barriers;implementation intervention;improved;improved outcome;Incidence;Inferior;Intake;Intervention;intervention cost;Malignant Breast Neoplasm;member;Mental Depression;Modeling;mortality;muscle form;Nutrient;older adult;Older Population;older women;Oncology;Outcome;Participant;Patient Outcomes Assessments;Patients;Persons;Physical Function;Play;Population;predictive modeling;preservation;programs;protein intake;Proteins;psychologic;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Recurrence;Recurrent disease;resistance exercise;Risk;Role;SEER Program;Self-Help Devices;Severities;Site;Sleep;Supplementation;Symptom Burden;Tablets;telehealth;Therapeutic;Toxic effect;translational goal;treatment center;Treatment outcome;treatment planning;Treatment Protocols;Treatment-related toxicity;Woman;young woman

PROJECT_TITLE: TeleHealth Resistance exercise Intervention to preserve dose intensity and Vitality in Elder breast cancer patients (THRIVE)


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Genetics;Human Genome;Microbiome;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: WINSTON-SALEM

ORG_DEPT: NEUROSCIENCES

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative In recent years it has become increasingly evident that the gut microbiome, the resident population of bacteria in the intestines, plays a key role in health and homeostasis throughout the body including the brain. Our laboratory has found that changes in the gut microbiome can alter the development of drug craving in animal models of relapse and affect how genes are expressed in the brain. These studies will identify how specific manipulations of the microbiome and its molecular byproducts affect brain and behavior, and will provide strategies for targeting the gut microbiome to reduce substance use disorders.

PI_NAMEs: KIRALY, DREW  (contact)

PROGRAM_OFFICER_NAME: WU, DA-YU

PROJECT_TERMS: Abstinence;Acute;Affect;Animal Model;Animals;Antibiotics;Automobile Driving;Bacteria;Behavior;Behavioral;Behavioral Assay;behavioral study;Biological Assay;Brain;brain shape;Cell Nucleus;Chromatin Structure;Cocaine;cocaine seeking;cocaine use;Cocaine use disorder;Complex;Corpus striatum structure;cost;Coupled;CREB1 gene;Crossover Design;Cues;Data;Development;Disease;Distant;Dose;drug abstinence;drug craving;drug development;Drug Modelings;drug of abuse;drug relapse;drug seeking behavior;Drug usage;Epigenetic Process;experimental study;Family;FDA approved;Foundations;Gene Expression;gene network;Genes;Genetic Transcription;genome-wide;Grant;gut microbiome;gut-brain axis;Health;Histone Acetylation;Homeostasis;human subject;Immune system;Incubated;Individual;insight;Intestines;Laboratories;loved ones;Mediating;microbiome;microbiome alteration;microbiome analysis;microbiome composition;Modeling;Molecular;Molecular Analysis;Morbidity - disease rate;mortality;neural circuit;Neurobiology;neuropsychiatry;Nucleus Accumbens;Paper;Pathologic;Pathway interactions;Patients;Pattern;permissiveness;Pharmaceutical Preparations;Pharmacotherapy;Phase;Play;Population;preference;prevent;Production;prolonged abstinence;psychostimulant;Public Health;Publications;Publishing;receptor;reconstitution;reduced substance use;Relapse;relapse risk;Research;response;Rewards;Risk Reduction;Role;Signal Transduction;small molecule;Societies;Specificity;stimulant dependence;stimulant use;stimulant use disorder;Structure;substance use;Substance Use Disorder;Synaptic plasticity;System;Testing;transcription factor;transcriptome sequencing;translational approach;Translational Research;translational study;Vagus nerve structure;Volatile Fatty Acids;Withdrawal;Work

PROJECT_TITLE: Targeting gut brain-signaling to reduce cocaine seeking behaviors

STUDY_SECTION: MCNP

STUDY_SECTION_NAME:
Molecular and Cellular Neuropharmacology Study Section
[MCNP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Genetics;Human Genome;Neurodegenerative;Neurosciences

PROJECT_TERMS: Addendum;Affect;Biological Markers;Biological Models;Biology;Brain;Brain region;Cell Nucleus;Code;college;Communities;Complex;Cytoplasm;Data;Dedications;Disease;Doctor of Medicine;Doctor of Philosophy;empowerment;Event;Exons;Frontotemporal Lobar Degenerations;frontotemporal lobar dementia amyotrophic lateral sclerosis;Functional disorder;Gene Expression;Genetic;genetic risk factor;genome wide association study;Genomics;Goals;Guidelines;Heterogeneity;high resolution imaging;Human;Human Genetics;human imaging;human tissue;Impairment;individualized medicine;innovation;Lasers;Lead;London;loss of function;Mediating;Methods;Monitor;multimodality;Nerve Degeneration;Neurology;Neurons;Neurosciences;novel;Nuclear;Pathogenesis;Pathology;Patients;Peptides;Play;Process;programs;protein TDP-43;Research;Research Project Grants;Resolution;Resources;response;RNA Splicing;RNA-Binding Proteins;Role;specific biomarkers;Structure;tau Proteins;Testing;therapeutic target;Time;transcriptome sequencing;Universities;Validation;Vision;web portal

PROJECT_TITLE: Cryptic exon splicing mediated by TDP-43 loss of function as the underlying mechanism of pathogenesis in FTLD-TDP


NIH_SPENDING_CATS: Biotechnology;Cancer;Clinical Research;Colorectal Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

ORG_STATE: TX

PHR: NARRATIVE Dysfunction and exhaustion of T cells is a major barrier in successful immunotherapy for cancer. We propose to investigate the molecular mechanism by which the novel Zbtb42/T-bet complex regulates effector function vs. exhaustion of CD8+T cells. Our studies could lead to clinical trials to overcome the current limitations of CAR-T cell therapy for cancer.

PI_NAMEs: POOJARY, VENUPRASAD K (contact)

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Antitumor Response;Binding;cancer immunotherapy;Cancer Model;cancer regression;cancer therapy;CAR T cell therapy;Carcinoembryonic Antigen;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;chimeric antigen receptor T cells;Clinical Trials;Colon Carcinoma;Complex;CRISPR/Cas technology;Data;Equilibrium;Event;exhaust;exhaustion;Family;Functional disorder;Gene Expression Profile;Immune;improved outcome;Interferon Type II;Interferons;Knock-in Mouse;MC38;Mediating;member;Meprin;Molecular;Mus;novel;Pathway interactions;patient derived xenograft model;Patients;Play;Post-Translational Protein Processing;prevent;programmed cell death protein 1;promoter;protein complex;protein degradation;Regulation;Reporting;Role;Solid Neoplasm;Sumoylation Pathway;T cell response;T-bet protein;T-Lymphocyte;Testing;therapeutic evaluation;therapeutic target;transcription factor;tumor;tumor growth;tumor microenvironment;Tumor Promotion;Tumor stage;Tumor-Infiltrating Lymphocytes;ubiquitin ligase;Ubiquitination

PROJECT_TITLE: Regulation of CD8+T cells by Zbtb42

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project narrative  Interpreting the world around us requires putting together current sensory experiences and our prior experience. It has been known for a long time that such prior core knowledge of the world plays a critical role in our perceptions. Yet, the mechanisms by which such experiences are merged with sensory stimuli remain poorly understood and elusive. Here we combine behavioral measurements, direct recordings of neural data from inside the human brain, invasive electrical stimulation, and computational models to investigate the neural circuits that combine the senses and prior experiences during visual search. There are multiple neurological and psychiatric conditions that are characterized by abnormal top-down signaling, conditions that remain poorly understood and where successful treatment will necessitate deep understanding of their mechanistic basis. The current proposal combines state-of-the-art technologies, methods and models to tackle these questions and begin to shed light on one of the most challenging mysteries of the mind, the interplay between the senses and high-level cognition.

PI_NAMEs: KREIMAN, GABRIEL  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Appearance;Attention;attentional modulation;Award;Behavior;behavior measurement;behavior prediction;Behavioral;Belief;Brain;Clutterings;Cognition;Cognitive;cognitive function;Cognitive Science;Communication;Complex;Computer Graphics;Computer Models;convolutional neural network;Cues;Data;Data Set;Diet;Electric Stimulation;experience;experimental study;Eye;Eye Movements;Glues;Goals;Human;Image;Inferior;Knowledge;Left;Link;Location;luminance;Maps;Measurement;Measures;member;Methods;Mind;Modeling;neural;neural circuit;Neurologic;neuromechanism;neurophysiology;novel;object recognition;Pattern;Perception;Physiological;Physiology;Play;predicting response;Prefrontal Cortex;Process;Property;Psychophysics;Reaction Time;Resolution;response;Role;sample fixation;Searching Behavior;Sensory;sensory input;sensory stimulus;Series;Short-Term Memory;Signal Transduction;Source;spatial integration;spatiotemporal;Stress Tests;Technology;Telephone;Temporal Lobe;Testing;theories;Time;Training;Update;Variant;Vision;Visual;Visual Cortex;Visual impairment;visual information;Visual Psychophysics;visual search;Visual System;Work

PROJECT_TITLE: Neural dynamics underlying spatiotemporal cognitive integration


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Aging;Cancer;Contraception/Reproduction;Neurosciences;Physical Injury - Accidents and Adverse Effects;Prostate Cancer;Regenerative Medicine;Urologic Diseases

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Narrative Our recently published studies have identified the protein Fidgetin-like 2 (FL2) as a novel regulator of microtubule dynamics. With targeted FL2-depletion, there is accelerated nerve regeneration and improved erectile function outcomes in animal models of radical prostatectomy (RP). The present proposal expands these studies by investigating mechanisms by which FL2-depletion enhances nerve regeneration through the recruitment of cells involved in nerve repair and determining the extent to which targeted FL2-depletion improves erectile function outcomes in rat models of nerve injury.

PI_NAMEs: DAVIES, KELVIN P (contact);SHARP, DAVID JAMES

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Acceleration;Affect;Age;age effect;aged;Aging;Animal Model;animal old age;Antigen-Presenting Cells;Apoptosis;Architecture;Axon;axon growth;axon regeneration;behavioral response;Bilateral;Blood flow;cell type;Cells;Chronic;Complex;Cytoskeleton;density;Electric Stimulation;Electron Microscopy;Endothelial Cells;Endothelium;Enzymes;Erectile dysfunction;Fibrosis;Functional Regeneration;Immune;Immunohistochemistry;improved;In Vitro;in vivo;in vivo Model;Injury;juvenile animal;Maintenance;Measurement;men;Microscopic;Microtubules;migration;Modeling;molecular marker;Morphology;Motility;Nerve;nerve injury;Nerve Regeneration;nerve repair;nerve supply;neural;neuron loss;neuronal cell body;Neurons;Nitroxidergic Nerves;NOS2A gene;novel;novel therapeutic intervention;older men;Operative Surgical Procedures;Outcome;penis;Peripheral Nerves;preservation;pressure;prevent;Process;Proteins;Publishing;Quantitative Reverse Transcriptase PCR;Radical Prostatectomy;Rattus;Recovery;recruit;repair function;Research;response;response to injury;Rodent Model;Schwann Cells;Site;Small Interfering RNA;Systemic blood pressure;TdT-Mediated dUTP Nick End Labeling Assay;Testing;Time;Tissues;Trichrome stain;Visual;Western Blotting

PROJECT_TITLE: Targeting the microtubule cytoskeleton to promote cavernous nerve regeneration and erectile function after injury

STUDY_SECTION: KUFD

STUDY_SECTION_NAME: Kidney and Urological Systems Function and Dysfunction Study Section[KUFD]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Bioengineering;Brain Disorders;Burden of Illness;Caregiving Research;Clinical Research;Dementia;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: San Clemente

ORG_NAME: ADAPTELLIGENCE, LLC

PHR: PROJECT NARRATIVE We propose to perform research and development to refine and extend a commercial application that can predict an individual's cognitive and mobility-based health using patterns learned from sensor data collected from a smart watch, and effectively and efficiently present this information to the caregiver. The application also provides opportunities to learn about healthy brain behavior and to track the integration of these behaviors into a person's routine. This research is relevant to public health because these technologies can extend the functional independence of our aging society through technology-assisted health self-management, reduce caregiver burden, and improve quality of life.

PI_NAMEs: COOK, DIANE JOYCE;HOLDER, LAWRENCE  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Activities of Daily Living;activity marker;Address;Aging;Alzheimer's disease related dementia;Awareness;Behavior;brain behavior;brain health;Caregiver Burden;Caregivers;Chronic;clinical predictors;Cognitive;commercial application;commercialization;Data;data dashboard;design;Development;digital;Early Diagnosis;effective therapy;Environment;Equilibrium;experience;Feedback;functional independence;Future;Goals;Health;health assessment;health care availability;Health Care Costs;Health Status;Home;improved;Individual;innovation;insight;Label;Learning;Life;Machine Learning;machine learning method;Marketing;Measures;mobile sensing;older adult;Older Population;Participant;Pattern;Persons;Phase;physical conditioning;Population;Public Health;Quality of life;Research;research and development;Sampling;Self Management;sensor;Services;smart watch;Societies;System;Technology;Time;Visual;Work

PROJECT_TITLE: Automated Health Assessment through Mobile Sensing and Machine Learning of Daily Activities


NIH_SPENDING_CATS: Bioengineering;Clinical Research;Networking and Information Technology R&D (NITRD);Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: SANTA MONICA

ORG_NAME: NEOCARE INNOVATIONS, INC.

PHR: For infants admitted to a Neonatal Intensive Care Unit (NICU), successful oral feeding is a requirement for discharge home, but preterm infants often struggle with oral feeding skills largely due to problems coordinating swallowing with breathing due to neurodevelopmental immaturities. Our technology is a clinical decision support tool that optimizes feeding of the preterm infant as it quantifies the complexity of breathing patterns giving clinicians a tool to better inform decisions related to oral feeding advancement. Creating technology that helps infants feed better so they can go home sooner promotes parent-infant interactions and optimizes infant development.

PI_NAMEs: BRADLEY, CAR  (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;Admission activity;Algorithms;Beds;Behavioral;Benchmarking;Breathing;Cardiopulmonary;care outcomes;Caregivers;Caring;Clinical;clinical decision support;clinical decision-making;clinically relevant;clinically significant;cloud based;Computer software;cost;cost effective;Custom;Data;Data Aggregation;Data Analytics;Data Collection;Data Storage and Retrieval;Deglutition;design;Devices;Economic Burden;Electrocardiogram;Electrodes;Electronic Health Record;Ensure;Entropy;experience;Family;feasibility testing;feeding;Focus Groups;Frustration;Future;Goals;Guidelines;Health;Health Care Costs;Healthcare;healthcare burden;Heart Rate;heart rate monitor;Home;Hospitals;human subject;Impedance Cardiography;improved;Individual;Infant;Infant Development;infant outcome;innovation;Intervention;invention;Length of Stay;Measures;Medical;Medical Device;Medical Records;Medical Students;mobile application;Modeling;Monitor;Neonatal Intensive Care;Neonatal Intensive Care Units;novel;Nurses;Oral;Outcome;Outcome Measure;Output;Oxygen;Parents;Patient Care;Pattern;Performance;Phase;Physiological;Pilot Projects;portability;premature;Premature Infant;Process;programs;prospective;prototype;recruit;Research Personnel;respiratory;Running;Sampling;skills;software development;Specific qualifier value;standard of care;Stress;success;support tools;System;Technology;Testing;Time;tool;United States;usability;verification and validation;Visual

PROJECT_TITLE: Pedi-Sync: A Clinical Decision Support Tool to Improve Oral Feeding Outcomes in Preterm Infants

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 HSS-J (10)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cystic Fibrosis;Gene Therapy;Genetics;Lung;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_NAME: OGB5, INC.

PHR: NARRATIVE The standard of care is ineffective for a subset of the CF patient population. Direct gene modulation via gene therapy, despite a highly safe profile with partial therapeutic effects after successful delivery in CF patients, remains limited due to viral-based methods. This proposal intends to develop a non-viral gene therapy method to treat cystic fibrosis that will move a novel non-viral platform one step closer to FDA IND filing and commercialization.

PI_NAMEs: SHEEHAN, COLIN T. (contact);ZIADY, ASSEM G

PROJECT_TERMS: 2,4-Dinitrophenol;Address;Affect;African American;Age;airway epithelium;Alveolar;Animal Model;Automobile Driving;autosome;Biodistribution;Biological Models;Biological Products;Biological Response Modifier Therapy;Bioluminescence;bronchial epithelium;Cell Culture Techniques;Cell Surface Receptors;cell type;Cells;Cellular Tropism;Charge;Chronic lung disease;commercialization;complement system;Cystic Fibrosis;cystic fibrosis patients;Cystic Fibrosis Transmembrane Conductance Regulator;Delta F508 mutation;Disease;DNA;Dose;Drug Formulations;Dryness;Electrophysiology (science);Enhancers;Epithelial Cells;Evaluation;Exhibits;experimental study;Formulation;Functional disorder;functional improvement;Gene Combinations;Gene Delivery;Gene Expression;Gene Mutation;gene therapy;Gene Transfer;gene transfer vector;Genes;Genetic Diseases;Hepatocyte;Human;human subject;Immunofluorescence Immunologic;immunogenicity;improved;In Vitro;in vivo;ineffective therapies;Inflammation;Inflammatory;Inhalation;Latino;Libraries;Liquid substance;Liver;Lung;Measures;Membrane;Methods;Mucous body substance;Mucous Membrane;Mus;nanoparticle;nanoparticle delivery;Nebulizer;next generation;non-viral gene delivery;non-viral gene therapy;novel;Nuclear;nucleolin;Organ;Other Genetics;Pancreas;particle;patient population;Pattern;Persons;Phase;Production;Protein Inhibition;Proteins;Pulmonary Cystic Fibrosis;pulmonary function;Reporter;Reporter Genes;Reporting;Research;Reverse Transcriptase Polymerase Chain Reaction;Risk;RNA;Small Business Innovation Research Grant;small molecule;standard of care;Structure of parenchyma of lung;success;Surface;survival prediction;System;targeted treatment;Technology;Technology Transfer;Testing;Therapeutic;Therapeutic Effect;therapeutic gene;Thick;Tissues;trafficking;Transcript;Transfection;transgene delivery;transgene expression;Transgenes;Transgenic Mice;Tropism;United States;uptake;Validation;Viral;Viral Genes;Western Blotting;Wild Type Mouse;Work

PROJECT_TITLE: A non-viral nanoparticle gene therapy delivery platform for treating Cystic Fibrosis and other diseases

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-B (11)]


NIH_SPENDING_CATS: Cardiovascular;HIV/AIDS;Heart Disease;Infectious Diseases;Precision Medicine;Prevention

PHR: Project Narrative Over 38 million people in the world live with HIV and are at greater risk of developing cardiovascular diseases, even when receiving treatment for HIV. Because people living with HIV receive medications that affect the body’s metabolism towards developing cardiovascular diseases, we will use state-of-the-art methodologies to determine the relationship between exposure from these drugs and important metabolism markers. We will identify the effects of drug exposure and pioneer a new area of HIV/AIDS research and more reliably predict the development of cardiovascular diseases for those living with HIV.

PI_NAMEs: DEVANATHAN, AARON SRIRAM (contact)

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Address;Affect;Anti-Retroviral Agents;antiretroviral therapy;Apolipoprotein A-I;Area;Biochemical;Biological Markers;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder risk;Ceramides;Clinical;Cohort Studies;comorbidity;Computational Biology;cytokine;Development;Disease;drug development;Drug Exposure;Drug Targeting;HIV;HIV/AIDS;Homeostasis;Inflammation;Inflammatory;interest;Knowledge;Measurement;Mediation;Metabolic;Metabolic Diseases;Metabolism;metabolomics;Methodology;Methods;Modification;Molecular;Monitor;multidisciplinary;multiple omics;Pathogenesis;personalized medicine;Persons;Pharmaceutical Preparations;Pharmacometabolomics;Physiology;Plasma;Population;Principal Component Analysis;Process;Research;research study;response;Risk;Risk Assessment;Risk Factors;risk stratification;Saturated Fatty Acids;specific biomarkers;Specimen;System;systemic inflammatory response;The Multicenter AIDS Cohort Study;transcriptomics;Viremia;Women's Interagency HIV Study

PROJECT_TITLE: Multiomics and Antiretroviral Drug Exposure for assessing Metabolic Effects (MADE-FOR-ME)

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 IIDB-P (55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cocaine;Drug Abuse (NIDA only);Machine Learning and Artificial Intelligence;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE This project aims to explore how neuromodulation, specifically neurotensin, plays a critical role in valence assignment in the basolateral amygdala, a site identified as a divergence point in circuits mediating positive and negative valence. This project will test the hypotheses that neurotensin directs valence-specific information to the appropriate downstream BLA projections during valence processing and modulates compulsive cocaine- seeking behavior. The proposed research project will broaden our understanding of the fundamental neuromodulatory mechanisms underlying valence processing and motivated behavior and identify neurotensin as a novel target for treating valence-disorders including substance use disorders.

PI_NAMEs: LI, HAO  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adaptive Behaviors;addiction;adverse outcome;Affect;Amino Acids;Amygdaloid structure;approach behavior;Award;Behavior;Behavioral;behavioral response;Cell Nucleus;classification algorithm;Clustered Regularly Interspaced Short Palindromic Repeats;Cocaine;Cocaine Dependence;cocaine seeking;Code;Computer Vision Systems;Conflict (Psychology);Control Groups;CRISPR/Cas technology;Cues;Data;Decision Making;discrimination task;Disease;Dissociation;drug addict;Drug Addiction;Drug usage;E-learning;Electrophysiology (science);experimental study;Faculty;flexibility;Functional disorder;Genes;genetic manipulation;Glean;Glutamates;Human;Impairment;in vivo;Infusion procedures;Intake;knock-down;Learning;Machine Learning;Mediating;motivated behavior;Mus;Negative Valence;neural;neural correlate;Neural Pathways;neuromechanism;Neurons;neuroregulation;Neurotensin;neurotensin type 1 receptor;novel;Nucleus Accumbens;optogenetics;Pathologic;Pattern;Peptides;Pharmaceutical Preparations;Phase;Play;Population;Positioning Attribute;Positive Valence;Property;Punishment;receptor expression;recreational drug use;Research;Research Project Grants;Resistance;response;Rewards;Rodent;Rodent Model;Role;Route;Scientific Advances and Accomplishments;Secure;Self Administration;Shock;Signal Transduction;Site;Source;Structure of paraventricular nucleus of thalamus;Substance Use Disorder;Sucrose;tenure track;Testing;Thalamic structure;tool;Training;transmission process;Universities;Viral;Visualization

PROJECT_TITLE: Determining how neurotensin mediates valence processing and compulsive cocaine seeking