NIH_SPENDING_CATS: Autoimmune Disease;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Heart Disease;Pediatric;Physical Activity;Prevention

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE Risk of cardiovascular disease (CVD) death is extremely high in type 1 diabetes, and insulin resistance predicts CVD in these individuals. This research will investigate, in participants with type 1 diabetes, the impact of glucagon like peptide-1 receptor agonism and exercise training on microvascular dysfunction, a common condition which worsens insulin resistance and may reduce exercise tolerance and fitness. The results of this investigation will provide important mechanistic insight into microvascular dysfunction in type 1 diabetes and examine an adjuvant treatment modality to improve it, which could have important public health implications for improving exercise tolerance, insulin resistance, and CVD in the future.

PI_NAMEs: LOVE, KAITLIN M (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Address;Adjuvant Therapy;Adult;Agonist;Antioxidants;Arteries;Attenuated;Award;Biometry;Blood Vessels;cardiorespiratory fitness;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular effects;career;Cell Physiology;Cells;Cellular biology;Cessation of life;Chronic;Clinical Research;Clinical Trials;contrast enhanced;Data;Data Analyses;data management;Disease Outcome;Endothelial Cells;endothelial dysfunction;Endothelium;Ensure;Exercise;exercise adherence;Exercise Tolerance;exercise training;Exhibits;fitness;Future;GLP-I receptor;glucagon-like peptide 1;Glucose;glucose uptake;Goals;Harvest;Health;Heart failure;Human;Hyperglycemia;Impairment;improved;improved outcome;in vivo;Individual;innovation;insight;Institution;Insulin;Insulin Resistance;Insulin-Dependent Diabetes Mellitus;Interval training;Investigation;Knowledge;Link;Measures;Mediating;Mentors;Mentorship;Methodology;Microvascular Dysfunction;Modality;Muscle;Muscle function;Nitric Oxide;Non-Insulin-Dependent Diabetes Mellitus;NOS3 gene;Obesity;Outcome;Oxidative Stress;Oxidative Stress Induction;Oxygen;Participant;Pathway interactions;Perfusion;Persons;Phosphorylation;Physical activity;Physiological;Pilot Projects;Placebos;Plasma;Play;Population;post intervention;prevent;Production;Public Health;Randomized;Reactive Oxygen Species;Research;Resources;response;Role;Signal Transduction;Site;Skeletal Muscle;Stains;Stimulus;Techniques;Testing;Therapeutic;Tissues;Training;ultrasound;United States National Institutes of Health;uptake;vascular endothelial dysfunction;Vascular Endothelium;Vasodilation;VO2max;Work;Youth

PROJECT_TITLE: Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: RELEVANCE Although the risk of hypertension increases in women at menopause the biological mechanisms underlying this increased hypertension susceptibility is uncertain. Using a multidisciplinary strategy incorporating sophisticated approaches we will investigate the brain mechanisms of menopausal hypertension using a novel model of accelerated ovarian failure in mice. A better grasp of the mechanisms underlying the emergence of hypertension associated with ovarian failure will aid in developing more effective diagnostic and therapeutic strategies for the gender-specific management of blood pressure.

PI_NAMEs: GLASS, MICHAEL J;MILNER, TERESA A (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: 4-vinylcyclohexene diepoxide;Acceleration;Aging;Agonist;AMPA Receptors;Anatomy;Angiotensin II;Animals;Area;Award;Biological;Blood Pressure;blood pressure control;blood pressure elevation;blood pressure regulation;Brain;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;cell type;Cells;Characteristics;Coupled;Data;Diagnostic;Dissociation;emerging adult;ESR1 gene;Estrogen Receptor 2;Estrogens;Event;Female;Gender;Gene Silencing;Gene Targeting;Gene Transfer;Genes;Genetic Transcription;Glutamate Receptor;glutamatergic signaling;Gonadal Steroid Hormones;GPER gene;Grant;grasp;Hormonal;Hormonal Change;Human;Hypertension;Hypothalamic structure;Immunoelectron Microscopy;In Situ Hybridization;in vivo;Incidence;Literature;male;Mediating;men;Menopause;middle age;Modeling;modifiable risk;mouse model;multidisciplinary;Mus;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;neurogenic hypertension;neuromechanism;Neurons;neurophysiology;Neurosecretory Systems;novel;ovarian failure;Ovariectomy;paraventricular nucleus;patch clamp;Perimenopause;Play;Postmenopause;pre-clinical;Pre-Clinical Model;Predisposition;prevent;Process;Production;Receptor Signaling;Resolution;Risk;Rodent Model;Role;Sex Differences;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Synaptic plasticity;Testing;Therapeutic;Tissue-Specific Gene Expression;Transcriptional Regulation;transcriptomics;Woman

PROJECT_TITLE: Contribution of G protein coupled estrogen receptor to changes in hypothalamic plasticity and hypertension susceptibility in mice with accelerated ovarian failure

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease;Rare Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Nephrotic syndrome (NS) is an important cause of progressive renal failure with the notable exception of Minimal change disease (MCD), which is highly responsive to treatment in spite of having podocyte cytoskeletal injury similar to other NS. We identified AMP-kinase as a specific signal in MCD podocytes which enables their survival in spite of injury. Our work here will study a large case series of human NS to establish innovative diagnostic methods for MCD based on AMPK activity that will also have prognostic value, and use pharmacologic and genetic models to develop and repurpose AMP-Kinase activators for use in all NS.

PI_NAMEs: MENON, MADHAV C (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 1 year old;Actins;adenylate kinase;Adriamycin PFS;aged;Albuminuria;Autophagocytosis;biobank;Biological Models;Biopsy;Case Series;Case Study;Cell Survival;cohort;Cytoplasm;Cytoskeleton;Data;design;Diagnostic;Diagnostic Procedure;Diffuse;Dimensions;Disease;End stage renal failure;Event;FDA approved;Focal and Segmental Glomerulosclerosis;Foot Process;FYN gene;Genetic;Genetic Models;glomerulosclerosis;Growth;Human;Hypertrophy;In Vitro;in vitro Model;in vivo;inhibition of autophagy;injured;Injury;innovation;Investigation;Kidney Failure;knock-down;Mediating;Modeling;Morphology;morphometry;Multiple Trauma;Mus;Nephrectomy;Nephrotic Syndrome;novel;novel therapeutics;overexpression;Pathology;Pathway interactions;pharmacologic;Phenotype;Phosphotransferases;podocyte;preservation;prevent;prognostic value;protective effect;Proteinuria;Proteomics;Proto-Oncogene Proteins c-fyn;Regulation;response;Role;self-renewal;Signal Transduction;STK11 gene;Stress;Technology;Testing;Therapeutic;Toxin;transcriptomics;treatment response;Visualization;Work

PROJECT_TITLE: Role of AMP-kinase pathway in the regulation of Minimal change disease-to-FSGS transition

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Health Services;Patient Safety;Prevention;Primary Health Care

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Many middle-aged and older adults who live with multimorbidity report abandoning their medications or skipping doses because of cost. Patients are unable to account for medication costs when making medical decisions, because they rarely know what those costs will be before getting to the pharmacy. Under the guidance of her mentors, Dr. Sloan will evaluate the uptake and acceptability of a novel clinician-facing out-of-pocket price transparency tool, as well as its impact on clinical outcomes and adherence among middle-aged and older adults with multimorbidity.

PI_NAMEs: SLOAN, CAROLINE ELLEN (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Academic Medical Centers;acceptability and feasibility;Address;Adherence;Adopted;Affect;aged;Assessment tool;Award;barrier to care;career;Caring;Cessation of life;Characteristics;Chronic;Clinical;Clinics and Hospitals;Colorado;comorbidity;Complex;cost;cost estimate;Cost-Sharing Insurance;Data;Decision Making;Dedications;design;Development;diabetes control;Diabetes Mellitus;Disease Progression;disorder control;Dose;Drug Prescriptions;effectiveness evaluation;Elderly;Electronic Health Record;electronic health record system;Environment;Evaluation;experience;Financial Support;Foundations;Frequencies;General Population;Geography;Glycosylated hemoglobin A;Goals;Health Services;Health system;Healthcare;high risk;Hospitalization;implementation tool;Improve Access;improved;Institution;insurance plan;Internist;Intervention;Interview;Mediating;Medical;Medical Care Costs;Medicare;medication compliance;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;middle age;multiple chronic conditions;novel;older adult;older patient;Outcome;patient population;Patient-Focused Outcomes;Patients;Pattern;Perception;Pharmaceutical Preparations;Pharmacy facility;Policies;Policy Analysis;Price;primary care provider;Privatization;Program Evaluation;Reporting;Research;Research Personnel;Retrospective cohort study;Role;Site;Structure;Subgroup;Time;tool;Training;Uninsured Medical Expense;United States Centers for Medicare and Medicaid Services;Universities;uptake;usability;virtual

PROJECT_TITLE: Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Diabetes;Digestive Diseases;Genetics;Nutrition;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Dietary factors and metabolic disorders such as obesity and diabetes are increasingly contributing to pancreatic cancer diagnoses. Understanding how diet intersects with metabolism in the pancreas will expand the general knowledge of how cancer cells rewire their metabolism and how this may influence their progression to tumors. Targeting metabolic pathways in the pancreas in combination with dietary regulation may provide much needed therapies to prevent the development of pancreatic cancer and slow its growth.

PI_NAMEs: NOJI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Ablation;Acetyl Coenzyme A;Acinar Cell;amino acid metabolism;Amino Acids;Area;Biological Assay;Branched-Chain Amino Acids;cancer cell;Cancer cell line;cancer diagnosis;Cancer Etiology;cancer subtypes;Carbohydrates;Catabolism;Cell Separation;cell type;Cells;Cessation of life;Citric Acid Cycle;Clinical;Complex;Death Rate;Defect;Diabetes Mellitus;Diagnosis;Diazoxide;Diet;diet-induced obesity;dietary;Dietary Factors;drinking water;Duct (organ) structure;Energy-Generating Resources;Enzymes;epidemiology study;epigenetic regulation;Essential Amino Acids;Excretory function;experimental study;gene therapy;Generations;Genetic;genetic approach;genetic manipulation;Genetic Transcription;Glucose tolerance test;Growth;Growth and Development function;Growth Factor;Human;Hyperinsulinism;Impairment;Implant;implantation;In Vitro;in vivo;Individual;Infusion procedures;inhibitor;Insulin;Insulin Receptor;Insulin Resistance;insulin sensitivity;insulin signaling;Investigation;Isoleucine;Keto Acids;Knock-out;Knowledge;Label;Lesion;Leucine;Link;Lipids;Malignant neoplasm of pancreas;Malignant Neoplasms;Measures;Metabolic;Metabolic Diseases;Metabolic Pathway;Metabolism;Metaplasia;Modeling;Morphology;mouse model;Mus;Mutate;Mutation;neoplastic;neoplastic cell;novel;Obesity;Oncogenes;Oxidoreductase;Pancreas;pancreas development;pancreatic cancer cells;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Pathogenesis;Pathway interactions;Patients;pharmacologic;Phenotype;Plasma;Population;prevent;Production;promoter;Proteins;Regulation;response;Risk;Risk Factors;Role;Stress;Sulfonylurea Compounds;Testing;tumor;Tumor Burden;tumor growth;tumor initiation;tumor microenvironment;Tumor Promotion;Valine

PROJECT_TITLE: The role of branched-chain amino acid metabolism and hyperinsulinemia in pancreatic cancer


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: HATTIESBURG

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN MISSISSIPPI

ORG_STATE: MS

PHR: Project Narrative  The proposed research will provide novel information on vector stoichiometry and vector competence of a medically important mosquito. Comprehensive knowledge of the ecology of Aedes aegypti and its dengue vector competence is fundamental for implementing efficient control practices and developing technology that protects public health in tropical and subtropical regions where the species is present. More so as cities continue to expand, and global temperatures becomes warmer contributing to the species dispersal. .

PI_NAMEs: REYES TORRES, LIMARIE JUDITH (contact)

PROGRAM_OFFICER_NAME: MOITRA, KAROBI

PROJECT_TITLE: Bottom-up regulation and competition of Aedes aegypti (Diptera: Culicidae) larvae along an urbanization gradient in Puerto Rico: Effects on population performance and vector competence


ADMINISTERING_IC: ES

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Complementary and Integrative Health;Dietary Supplements;Genetics;Immunotherapy;Lung;Lupus;Nutrition;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: NUTRITION

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Autoimmune diseases (ADs) affect over 25 million Americans, inflicting tremendous individual suffering and societal burdens. Exposure to the earth’s most abundant mineral, crystalline silica (quartz), is common in individuals involved in construction, mining, farming, manufacturing and military deployment and increases their risk of developing systemic lupus erythematosus (lupus) and other ADs. Here we seek to understand the underlying mechanisms by which consumption of the omega-3 fatty acid docosahexaenoic acid (DHA) blocks silica-triggered lupus, thus yielding important new insights into how environmental toxicants trigger AD and how manipulating the lipidome through dietary fatty acid supplementation can prevent it.

PI_NAMEs: PESTKA, JAMES J (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Acceleration;Acids;Acute;adaptive immunity;Affect;Alveolar;Alveolar Macrophages;American;Autoantibodies;Autoantigens;Autoimmune Diseases;autoimmune rheumatologic disease;Autoimmunity;C57BL/6 Mouse;Cathepsins;Cell Death;Cessation of life;Chemosensitization;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Consumption;cytokine;Data;Development;Diet;dietary;Dietary Fats;Dietary Fatty Acid;dietary supplements;disability;DNA;Docosahexaenoic acid supplementation;Docosahexaenoic Acids;Dose;early onset;Eicosanoids;Embryo;Environment;Environmental Risk Factor;environmental stressor;Excision;Exposure to;Farm;fatty acid supplementation;Fatty Acids;Female;Fetal Liver;Fish Oils;Fishes;Flare;Gene Expression;genetic signature;Genome;Glomerulonephritis;Goals;Grant;Health;Heredity;Human;human disease;Immune Tolerance;immunogenic;immunogenic cell death;Immunotherapy;In Vitro;in vivo;Individual;Infectious Agent;Inflammation;Inflammation Mediators;Inflammatory;insight;Interferons;Interleukin-1;Interleukin-1 alpha;Interleukin-1 beta;Link;lipidome;Lipids;Liver;Lung;Lupus;Lymphoid Tissue;Lysosomes;Macrophage;manufacture;Military Personnel;Minerals;Mining;Mission;Modeling;mouse model;Mus;National Institute of Environmental Health Sciences;Natural Immunity;novel;Omega-3 Fatty Acids;Omega-6 Fatty Acids;particle;Pathway interactions;Phagocytes;Phenotype;Planet Earth;Play;Population;pre-clinical;Predisposing Factor;prevent;Production;Quartz;respiratory;response;Risk;Risk Factors;Role;Rupture;self-renewal;Severities;Silicon Dioxide;stressor;systemic autoimmunity;Systemic Lupus Erythematosus;Testing;Tissues;tool;Toxic Environmental Substances;toxicant;United States National Institutes of Health;Water

PROJECT_TITLE: Role of alveolar macrophage in omega-3 fatty acid amelioration of silica-triggered autoimmunity.

STUDY_SECTION: SIEE

STUDY_SECTION_NAME: Systemic Injury by Environmental Exposure[SIEE]


NIH_SPENDING_CATS: Behavioral and Social Science;Childhood Obesity;Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Nutrition;Obesity;Pediatric;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: CHILDREN'S HOSPITAL OF LOS ANGELES

ORG_STATE: CA

PHR: PROJECT NARRATIVE: Time-based interventions, such as time-limited eating, have been shown to be a promising dietary strategy for weight loss, glucose and lipid metabolism improvements, and overall well-being in adults with type 2 diabetes, however no study has investigated time-limited eating in adolescents with type 2 diabetes. Because of its simplicity, time-limited eating may represent a more flexible, non-stigmatizing, and low-cost approach for adolescents than other caloric restriction regimens. This project aims to determine if time-limited eating in adolescents with type 2 diabetes minimizes glycemic excursions, delays β-cell deterioration, and reduces body fat mass compared to a prolonged eating period.

PI_NAMEs: VIDMAR, ALAINA P (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Adherence;Adolescent;Adult;Age;aged;Behavior;Behavioral;Beta Cell;Bioinformatics;Black race;blood glucose regulation;Body Composition;Body fat;Body Weight;Body Weight decreased;Caloric Restriction;cardiometabolism;career development;Cell Physiology;Cells;Characteristics;Child Nutrition;Childhood;circadian pacemaker;Clinical;Clinical Trials Design;Communities;comparison control;Complex;Continuous Glucose Monitor;cost;Country;daily functioning;Data;Deterioration;Development;Diabetes Mellitus;Diagnosis;Diet;dietary;dietary approach;Dietary intake;Dietary Intervention;disease phenotype;Disease Progression;dosage;Dual-Energy X-Ray Absorptiometry;Eating;effectiveness evaluation;Energy Metabolism;Environment;Fasting;Fatty acid glycerol esters;flexibility;Functional disorder;functional restoration;Funding;gender expression;glucose metabolism;glucose monitor;glucose production;glycemic control;Glycogen;Glycosylated hemoglobin A;Goals;Hepatic;Hepatocyte;Hour;improved;indexing;Individual;insight;Institution;insulin secretion;insulin sensitivity;interest;Intervention;intervention effect;Latino;Life Style;lifestyle intervention;lipid metabolism;Lipids;Liver;Macronutrients Nutrition;Magnetic Resonance Imaging;mathematical ability;Measurement;Measures;Medical;Mentored Patient-Oriented Research Career Development Award;Mentors;Metabolic;Metformin;Methods;minimal risk;Monitor;Movement;Multicenter Trials;Non-Insulin-Dependent Diabetes Mellitus;Nutritional;Obesity;oxidation;Participant;Peripheral;Personal Satisfaction;Physical activity;Physicians;Pilot Projects;Population;post intervention;Prediabetes syndrome;Prevalence;Psychologist;Randomized;Recommendation;recruit;reduced food intake;Regimen;Research;response;Safety;Scanning;Schedule;Scientist;secondary outcome;Severities;skills;Sleep;Specific qualifier value;Statistical Methods;Structure;Technology;Testing;Time;Training;Visceral fat;Youth

PROJECT_TITLE: Impact of Meal Timing on Glycemic Profiles in Adolescents with Type 2 Diabetes


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: NARRATIVE Dysregulation of lysosome functions is associated with multiple diseases, including cancers and metabolic disorders. This proposal will test the hypothesis that phosphatidylinositol 5-phosphate 4-kinase beta (PI5P4Kβ) is activated by cellular GTP-energy and regulates lysosomal functions using pharmacological and molecular approaches that target PI5P4Kβ. Public Health Relevance

PI_NAMEs: SASAKI, ATSUO  (contact)

PROGRAM_OFFICER_NAME: MASKERI, BAISHALI

PROJECT_TERMS: Acute;Affect;Amino Acid Substitution;Anabolism;Autophagocytosis;Binding;Biogenesis;Catabolism;cell growth;Cell Proliferation;Cells;Cellular Metabolic Process;Cellular Stress;Collaborations;Coupled;Cytoprotection;Degradation Pathway;Dependence;Disease;Embryo;Energy Metabolism;Enzymes;Exhibits;Family;Fasting;Fibroblasts;Genes;Genetic;Genetic Transcription;Growth;Guanosine Triphosphate;Heart;Hepatic;Hepatocyte;High Fat Diet;Homeostasis;human disease;Hypoglycemia;inhibition of autophagy;inhibitor;inorganic phosphate;Insulin Resistance;insulin sensitivity;Isoenzymes;kinase inhibitor;knock-down;Knock-in Mouse;Knock-out;Laboratories;Lipids;Liver;Lysosomes;Malignant Neoplasms;Mediating;Metabolic;Metabolic Diseases;Metabolism;Modeling;Molecular;multidisciplinary;Mus;novel;nutrient deprivation;Obesity;Organelles;Pathogenesis;Pathology;pharmacologic;Phenotype;phosphatidylinositol 5-phosphate;Phosphatidylinositols;Phosphotransferases;Physiological;PIK3CG gene;Play;Predisposition;Productivity;Property;Proteins;Proteomics;public health relevance;Reactive Oxygen Species;recruit;Regulation;Reporting;Research;response;reverse genetics;Role;scaffold;screening;Second Messenger Systems;sensor;Signal Transduction;Stress;stress resilience;System;Testing;tumor;tumorigenesis;vacuolar H+-ATPase;Wisconsin

PROJECT_TITLE: Mechanistic role of phosphatidylinositol 5-phosphate 4-kinase beta in GTP-dependent lysosomal acidification for stress-resilient cell growth and metabolism

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


ORG_CITY: STONY BROOK

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: 8. PROJECT NARRATIVE  The ability to create new intracellular membrane compartments de novo is a fundamental aspect of eukaryotic cell behavior. Disruption of processes that involve de novo assembly are implicated in many pathological syndromes including ciliopathies and neurodegenerative diseases. Understanding the mechanisms of membrane assembly and expansion is therefore important for human health. The process of sporulation in budding yeast provides an excellent model in which to study de novo membrane formation. The experiments in this proposal are focused on understanding the molecular events required for initiation of a new membrane compartment on the yeast spindle pole body and how the Vps13 lipid transfer protein promotes expansion of that membrane.

PI_NAMEs: NEIMAN, AARON M (contact)

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: Adaptor Signaling Protein;Address;Autophagosome;Biochemical;Biological Models;Biological Process;Bypass;cell behavior;Cell Differentiation process;Cell Physiology;Cells;Centrioles;ciliopathy;Cytology;Cytoplasm;D Cells;Defect;Disease;Docking;Encapsulated;Endoplasmic Reticulum;Eukaryotic Cell;Event;Experimental Genetics;experimental study;flexibility;Fluorescence;Generations;Genetic;Guanine Nucleotides;Health;Human;Hydrophobicity;in vitro testing;in vivo;insight;interest;Intracellular Membranes;Lead;Licensing;lipid transfer protein;Lipids;Mediating;Meiosis;Membrane;membrane assembly;Membrane Fusion;Microtubule-Organizing Center;Modeling;Molecular;Mutation;Nature;Nervous System Disorder;Neurodegenerative Disorders;Organelles;Orthologous Gene;Pathologic;Pathway interactions;Point Mutation;Population;Process;protein complex;Protein Family;protein purification;Proteins;rab GTP-Binding Proteins;recruit;Reporting;Role;Saccharomycetales;Site;SNAP receptor;spindle pole body;Surface;Syndrome;System;target SNARE proteins;Techniques;Testing;Vesicle;vesicular SNARE proteins;Yeasts

PROJECT_TITLE: Mechanisms of de novo membrane assembly

STUDY_SECTION_NAME: Cell Structure and Function 1 Study Section[CSF1]


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

PHR: Narrative  The endoplasmic reticulum (ER) stress response appears is a universal feature of all cardiomyopathies as well as healing after cardiac injury or disease initiation. Here we have identified a novel function for thrombospondin1 (Thbs1) as an intracellular regulator of the ER stress response that then leads to enhanced cardiac atrophy thorugh a specific signaling mechanism with the ER and that effects autophagosome formation. Understanding how and why Thbs1 has this unique molecular function is of medical relevance as many forms of heart disease are associated with ventricular remodeling and loss of tissue mass.

PI_NAMEs: MOLKENTIN, JEFFERY D (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: Acute;adenoviral mediated;Adult;Affect;Anorexia;Atrophic;Automobile Driving;Autophagocytosis;Autophagosome;Bed rest;Binding;Biological;biological adaptation to stress;Biological Assay;Biological Process;Biotin;Blood Platelets;Calcium Binding;Caloric Restriction;Cancer Cachexia;Cardiac;Cardiac Myocytes;Cardiomyopathies;Catabolic Process;Catabolism;Cells;Cellular biology;Complex;Data;Disease;Doxorubicin;Dystrophin;EIF-2alpha;Endoplasmic Reticulum;endoplasmic reticulum stress;Equilibrium;Extracellular Matrix;Extracellular Matrix Proteins;Family;Family member;Gene Expression Profile;Gene Family;Gene Modified;Gene Targeting;Gene Transfer;Genes;Genetic Transcription;Glycoproteins;healing;Heart;Heart Diseases;Heart failure;Heart Hypertrophy;Heart Injuries;Immunohistochemistry;Immunoprecipitation;in vivo;Injury;innovation;Integrins;Investigation;Knockout Mice;LAMP-2;Ligase;Location;Lysosomes;Malnutrition;Mammals;Mediating;Medical;Membrane;Messenger RNA;Metabolic;Molecular;Molecular Chaperones;mortality;mouse model;Movement;Mus;Mutant Strains Mice;Myocardium;Neonatal;neonatal mice;Nodal;novel;Nutrient;overexpression;Paper;Pathologic;Pathway interactions;Patients;Physiological;Play;pressure;Process;Protein Glycosylation;Protein Secretion;Proteins;Regulation;Regulatory Pathway;response;Role;Sarcolemma;Secretory Vesicles;Series;Signal Pathway;Signal Transduction;Skeletal Muscle;skeletal muscle wasting;Stains;Starvation;Stimulus;Stress;Striated Muscles;Testing;Thrombospondin 1;Thrombospondins;Time;Tissues;transcription factor;Transgenic Mice;Ventricular Remodeling;Vesicle;Work;Workload

PROJECT_TITLE: Thrombospondin1-regulated atrophy in the heart

STUDY_SECTION: BBHV

STUDY_SECTION_NAME: Basic Biology of Blood, Heart and Vasculature Study Section [BBHV]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The proposed studies will explore regulation of cellular viscosity, a fundamental cellular property that influences the nature and behavior of all living systems. This will increase our understanding of how cells survive environmental challenges and how cells may be dysregulated in disease.

PI_NAMEs: BRANDMAN, ONN  (contact)

PROJECT_TERMS: Acute;acute stress;Address;Affect;Aging;Area;Basic Science;Behavior;Biochemical Reaction;Biochemistry;biological adaptation to stress;Biology;Biophysical Process;biophysical properties;Biophysics;Brain;cancer cell;Carbohydrates;cell growth regulation;Cell Physiology;Cell Survival;cell type;Cells;Complex;Cues;Cytosol;Data;Diffusion;Disease;Disparate;Energy consumption;Environment;environmental stressor;Feedback;Glucose;Glycogen;Health;Human;Human body;Human Resources;Hypoxia;In Vitro;in vivo;Ischemic Stroke;Kinetics;Letters;Life;Link;Liver;Malignant Neoplasms;Mammalian Cell;Measures;Metabolic;Molecular;Muscle;Names;Nature;Neurodegenerative Disorders;Organism;Pathology;Pathway interactions;Phase;Polysaccharides;Production;Property;protein folding;Proteins;Reaction;reaction rate;Regulation;Regulatory Pathway;Research;response;Saccharomyces cerevisiae;Saccharomycetales;Signal Pathway;Stress;stress tolerance;stressor;Structure;System;Temperature;Testing;Up-Regulation;Viscosity;Work;Yeasts

PROJECT_TITLE: Cellular regulation of viscosity


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Mental Health;Mental Illness;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: TALLAHASSEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: FLORIDA STATE UNIVERSITY

ORG_STATE: FL

PHR: Anxiety is highly prevalent, distressing and disabling among those with Mild Cognitive Impairment (MCI) and Alzheimer’s Disease and Related Dementias (ADRD) as well as care partners. Moreover, anxiety appears to accelerate the development of cognitive decline among those with MCI but there is not an established treatment with potential for high dissemination, broad reach, and low participant burden that can be easily delivered at point-of-care settings. The current proposal builds upon existing work by evaluating the efficacy of a brief intervention that can significantly reduce anxiety and related distress in MCI/ADRD and care partners.

PI_NAMEs: ALLAN, NICHOLAS PAUL;SCHMIDT, NORMAN BRAD (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acceleration;Affective;Alzheimer's Disease;Alzheimer's disease related dementia;Anxiety;anxiety reduction;anxiety sensitivity;anxiety symptoms;Behavior Therapy;brief intervention;Cardiac;care providers;Caregiver Burden;Caring;Clinical;Clinical Trials;clinically significant;Cognitive;cognitive ability;cognitive function;Cognitive Therapy;Cohort Studies;conditioned fear;Data;Dementia;design;Development;Diagnostic;Disabling;Distress;Dropout;Early Onset Alzheimer Disease;efficacy evaluation;Emotional;Esthesia;Exercise;experience;follow-up;Health education;Impaired cognition;improved;Individual;Intervention;Learning;Maintenance;Mediating;Memory;Mental Depression;Meta-Analysis;mild cognitive impairment;mild traumatic brain injury;Motivation;multimodality;Neurobehavioral Manifestations;older adult;Participant;Patients;Persons;point of care;post intervention;Probability;psychoeducation;Psychopathology;Quality of life;Randomized;randomized, clinical trials;Research;Research Domain Criteria;Research Priority;respiratory;response;Risk;Risk Factors;Sampling;Sleeplessness;Social Functioning;Stimulus;Stress;stressor;Symptoms;Testing;Translational Research;Treatment outcome;Treatment Protocols;trial comparing;Work

PROJECT_TITLE: Randomized Clinical Trial of a Brief, Anxiety Intervention for Mild Cognitive Impairment/mild Alzheimer’s Disease and their Care Providers

STUDY_SECTION: APDA

STUDY_SECTION_NAME: Adult Psychopathology and Disorders of Aging Study Section[APDA]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative Release of the excitatory neurotransmitter glutamate depends on its storage inside synaptic vesicles. However, the ions important for glutamate uptake fluctuate dramatically as synaptic vesicles undergo exo- and endocytosis. We will now determine how the unusual properties of vesicular glutamate transport that we have identified serve to coordinate vesicle filling with events in the synaptic vesicle cycle.

PI_NAMEs: EDWARDS, ROBERT H (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TITLE: Glutamate Transport into Synaptic Vesicles


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Neurosciences

PHR: Modified Public Health Relevance Section  We aim to provide a causal link between a fundamental cortical computation (i.e. gain control), specific cell types and perceptual states. The dysregulation of cortical gain control has been strongly implicated as a cause of neuropsychiatric diseases such as autism and schizophrenia. Thus, linking this computation to the impact of specific cell types on both network activity and perceptual states is a necessary step in identifying the source of dysfunction and constraining the set of interventions that may be used in treatment of these conditions.

PI_NAMEs: GLICKFELD, LINDSEY L (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acute;Animals;area striata;autism spectrum disorder;Automobile Driving;Behavioral;cell cortex;cell type;Cells;Conscious;contextual factors;design;discrimination task;Disease;Dissociation;Etiology;experimental study;extracellular;Functional disorder;Future;Genetic;Glutamate Receptor;Goals;Health;Interneurons;Intervention;Investigation;Lead;Link;Measurement;Measures;Mediating;Monitor;Mus;neural;Neurons;neuropsychiatric disorder;optogenetics;Parvalbumins;Perception;Performance;Pharmaceutical Preparations;pharmacologic;Physiological;Process;Property;Psychophysics;public health relevance;Pyramidal Cells;recruit;Role;Schizophrenia;Sensory;Shapes;Somatostatin;Source;Stimulus;Synapses;System;Testing;Visual;Visual Cortex;Visual Perception;visual stimulus;Visual System

PROJECT_TITLE: Linking cortical circuit computations to visual perception

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: HOUSTON

ORG_NAME: RICE UNIVERSITY

ORG_STATE: TX

PHR: PROJECT NARRATIVE The proposed project is designed to use a biobehavioral approach, a stress-coping model, a culturally sensitive framework, and innovative methods in psychoneuroimmunology to provide novel information about how bereavement increases cardiovascular disease (CVD) risk, including detecting relevant ethnic disparities and identifying protective factors that promote resilience during this difficult life transition. Results from this project will provide critical evidence to inform the development of culturally and contextually sensitive interventions aimed at reducing disease burden in a vulnerable population. The longitudinal design will provide valuable information to identify critical time points for intervention.

PI_NAMEs: GARCINI, LUZ MARIA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acute;Adult;Anti-Inflammatory Agents;Bereavement;biobehavior;Biological Markers;burden of illness;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;Cells;Chronic;clinically significant;community based research;coping;Data;design;Development;Dimensions;Disparity;Emotions;Enrollment;ethnic difference;ethnic disparity;Ethnic Origin;Excess Mortality;experience;Exposure to;Faculty;Feedback;Five-Year Plans;Fostering;Foundations;Funding;Glucocorticoids;Goals;Grief reaction;health determinants;health disparity;Immune;Immune system;Individual;Inflammation;Inflammatory Response;innovation;Institution;Intervention;Interview;K-Series Research Career Programs;Knowledge;Latino;Latino Population;Lead;Life;Literature;longitudinal design;Longitudinal Studies;Measures;Mediator;Medical;Mentors;Mentorship;Methods;Modeling;Morbidity - disease rate;mortality;mortality risk;multidisciplinary;novel;Persons;promote resilience;protective factors;Psychoneuroimmunology;Research;resilience;Resistance;Resources;Risk;Risk Assessment;Science;skills;social health determinants;sociocultural determinant;Spouses;steroid hormone;Stress and Coping;Stressful Event;stressor;Surveys;Symptoms;therapy development;Time;Training;Visit;Vulnerable Populations

PROJECT_TITLE: Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Uterine Cancer;Women's Health Research

ORG_CITY: IRVINE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE The goal of this research is to further our understanding of endometrial cancer survival outcomes and survivorship experiences for Latina women through an exploratory sequential mixed methods approach. This study will have a positive impact on cancer disparities research by advancing the knowledge of the macro/systemic level contexts that influence and shape endometrial cancer survival outcomes and survivorship experiences among Latina women. Findings from this research will help to inform public health research and practice interventions to improve survivorship experiences and will set up future research inquiries to further examine endometrial cancer survival and survivorship among Latina women.

PI_NAMEs: RODRIGUEZ, VICTORIA ELIZABETH (contact)

PROGRAM_OFFICER_NAME: ADAMS, GREGORY

PROJECT_TERMS: Acceleration;Address;Age;California;cancer diagnosis;cancer epidemiology;cancer health disparity;cancer site;cancer survival;Cancer Survivor;Cancer Survivorship;cancer therapy;Caring;Clinical;Comprehensive Cancer Center;Data;Dedications;Diagnosis;Disease;Education;Educational workshop;Endometrial Carcinoma;Environment;Epidemiologic Methods;Equity;Ethnic Origin;Ethnic Population;experience;Fellowship;Female;follow-up;Gender;Goals;Grant;Gynecologic Oncology;Health;health inequalities;Health Insurance;Healthcare Systems;Immigrant community;improved;Incidence;Income;insight;Intervention;Interview;Journals;Knowledge;Latina;Latina Population;Latino;Length;Lived experience;low socioeconomic status;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of cervix uteri;Malignant neoplasm of ovary;Malignant Neoplasms;Mentors;Mentorship;Methodology;Methods;multilevel analysis;Neighborhoods;neoplasm registry;Outcome;programs;Public Health;public health research;Race;racial difference;racial population;recruit;Research;Research Methodology;Research Personnel;Sampling;Shapes;Site;skills;Socioeconomic Status;Survival Analysis;survival outcome;Survival Rate;survivorship;symposium;Training;United States;Universities;White Women;Woman;Writing

PROJECT_TITLE: Endometrial Cancer Survival and Survivorship among Latinas in California: A Mixed Methods Study

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F18-A(20)L]


ED_INST_TYPE: UNIVERSITY-WIDE

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

ORG_STATE: MA

PHR: Project Narrative  Parkinson’s disease is an irreversible neurodegenerative disease that is among the fastest growing neurological diseases in prevalence, associated disability, and death. Because cell death is irreversible, identifying early disease-events is critical for developing treatments that act before the brain is damaged beyond repair. The loss of axons of dopamine neurons in the Substantia Nigra pars compacta is one such early event, and the goals of this project are to better understand how subcellular molecular and functional specialization of mitochondria contribute to axon survival, and whether these processes are altered in mouse models of Parkinson’s disease.

PI_NAMEs: GE, PRESTON  (contact)

PROGRAM_OFFICER_NAME: SARRAF, SHIREEN AKHAVAN

PROJECT_TERMS: alpha synuclein;Axon;axon growth;axonal degeneration;Biological Assay;Biology;Brain;Cell Death;Cells;Cessation of life;Characteristics;Complex;Corpus striatum structure;Cytoplasm;Defect;density;Development;disability;disability-adjusted life years;Disease;disease model;disease phenotype;Distal;dopamine replacement therapy;dopaminergic neuron;Dorsal;Early identification;Event;Exhibits;experimental study;Face;functional adaptation;Functional disorder;Genetic;Genus Hippocampus;Goals;Human;imaging platform;in vivo;induced pluripotent stem cell;knock-down;Knowledge;Label;Light;Link;Maintenance;Membrane Potentials;Metabolic;meter;Mitochondria;mitochondrial dysfunction;mitochondrial membrane;Modeling;Molecular;Molecular Profiling;Morphology;Motor;motor symptom;mouse model;Mus;Nature;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuronal Dysfunction;Neurons;neuroprotection;novel;overexpression;Parkinson Disease;pars compacta;Pathologic;Pathway interactions;Population;Predisposition;presynaptic;Presynaptic Terminals;Prevalence;Process;Proteins;Proteomics;Public Health;repaired;resilience;Site;small hairpin RNA;Spatial Distribution;spatial relationship;Structure;Substantia nigra structure;symptom treatment;synaptic function;Testing;therapeutic target;Toxin;Ventral Striatum;Ventral Tegmental Area;Viral;Work

PROJECT_TITLE: Characterization of Dopamine Neuron Axonal Mitochondria Specialization and its Relevance to Parkinson’s Disease


NIH_SPENDING_CATS: Genetics;Neurosciences;Pediatric

ORG_CITY: Aurora

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Several neurodevelopmental disorders arise from defects in neurogenesis and neuronal migration. Though some work has been done, the underlying processes that contribute to normal neural development and the pathological mechanisms in disease remain not entirely known. This proposal focuses on using advanced bioinformatic analyses and molecular manipulations to understand how the meninges, a protective covering for the central nervous system, regulates brain development, how the failure of meninges formation impacts aberrant brain development and identify potential therapeutic strategies to help patients.

PI_NAMEs: COMO, CHRISTINA N (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Address;Apical;Bioinformatics;Biological Assay;Brain;Brain region;career;cell type;Cells;Central Nervous System;Communication;Data;Data Set;Defect;Development;developmental disease;developmental neurobiology;Developmental Process;Disease;Dorsal;Electroporation;Embryo;Ensure;experimental study;Failure;Fibroblasts;Focus Groups;FOXC1 gene;Goals;Human;Impairment;improved;in silico;in utero;inhibitor;insight;Knock-out;knockout animal;Knowledge;Lead;Leadership;Link;Meningeal;Meninges;Methods;migration;Molecular;Mus;mutant;Mutation;Neocortex;neocortical;nerve stem cell;nervous system development;neural;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;Neurons;notch protein;Notch Signaling Pathway;novel;paracrine;Pathologic;Pathology;Pathway Analysis;Pathway interactions;Patients;Phenotype;Population;Process;Production;progenitor;Prosencephalon;Proteins;Reporter;Research;Role;self-renewal;Signal Pathway;Signal Transduction;skills;small hairpin RNA;Specific qualifier value;stem cell self renewal;Supplementation;Testing;Therapeutic;Tissues;Training;transcription factor;transcriptome sequencing;transcriptomics;Tretinoin;Ventricular;Work

PROJECT_TITLE: Meninges Specification and Cellular Crosstalk to the Developing Brain


ADMINISTERING_IC: HD

ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Racial and Ethnic Minority Health Research

ORG_CITY: SAN DIEGO

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: SAN DIEGO STATE UNIVERSITY

PHR: Narrative Spanish speakers represent approximately 75% of all children learning two languages in the United States, yet there is a lack of tools to assess the home language of these bilingual children. The proposed project will develop a Spanish grammatical productivity measure to capture the emerging language abilities of young bilingual children (Aim 1) and evaluate the use of this Spanish measure in the reports of caregivers through a culturally adaptative framework (Aim 2). The results of this project will improve language assessment by informing how bilingual children, with and without a language disorder, produce Spanish grammar, and how caregiver reports on grammatical productivity can be used to characterize bilingual children’s language development.

PI_NAMEs: ESCOBEDO, ALICIA GUADALUPE (contact)

PROGRAM_OFFICER_NAME: SALO, VIRGINIA CHARLOTTE

PROJECT_TERMS: Address;Affect;Age;age related changes;aged;Assessment tool;bilingualism;Caregivers;Child;Child Language;Clinical;clinically relevant;Collaborations;Communication impairment;design;Development;Diagnosis;Disease;Education;Educational workshop;Ensure;experience;Family;Fostering;Frequencies;Growth;Home;improved;insight;Intervention;Language;Language Development;Language Development Disorders;Language Disorders;Learning;Linguistics;Measures;Modeling;Pathologist;Pattern;peer;Performance;Population;Preschool Child;Prevalence;Procedures;Process;Process Assessment;Productivity;Protocols documentation;Quality of life;Reduce health disparities;Reporting;Research;Sampling;School-Age Population;Spanish;Spanish/English;Speech;statistics;Structure;Surveys;tool;United States;Work

PROJECT_TITLE: Spanish Productivity in the Assessment of Spanish-English Bilingual Children


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Public Health Relevance Statement Our application is to examine how epigenetic factors control colorectal cancer (CRC) development and cancer stem cell functions and to determine whether target epigenetic factors inhibits CRC growth. The discoveries from this study will have important implications in developing novel therapeutic strategies for treating human CRCs.

PI_NAMEs: WANG, CUN-YU  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: adenoma;Alleles;APC gene;APC mutation;ApcMin/+ mice;ASCL2 gene;beta catenin;Biological Assay;cancer cell;cancer initiation;cancer stem cell;Cause of Death;CCND1 gene;Cell Proliferation;Cells;Chemicals;chemotherapy;ChIP-seq;Clinical;Colonic Neoplasms;Colorectal;Colorectal Cancer;colorectal cancer progression;CTNNB1 gene;Cyclin D1;demethylation;Development;drug resistance development;Enzymes;Epigenetic Process;Exhibits;Feedback;Gene Activation;Gene Silencing;Genes;Genetic;Genetic Transcription;Growth;histone demethylase;Human;Impairment;improved;in vivo;Individual;intestinal tumorigenesis;Intestines;knock-down;Knock-out;Label;LGR5 gene;LoxP-flanked allele;Lysine;Malignant Neoplasms;Mediating;Methylation;Modification;Molecular;mouse model;Mus;Mutation;neoplastic cell;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Oncogenic;patient derived xenograft model;Patient-Focused Outcomes;pharmacologic;Phenotype;Play;promoter;Property;public health relevance;Reaction;recruit;Recurrent tumor;Reporting;Resistance development;Role;self-renewal;Signal Pathway;Signal Transduction;Small Intestines;small molecule inhibitor;Stem Cell Factor;stem cell function;stem cell model;stem cell self renewal;stem cells;stemness;TCF Transcription Factor;Therapeutic;transcription factor;transcriptome sequencing;treatment strategy;tumor;tumor growth;tumor initiation;Tumor Stem Cells;tumorigenesis;tumorigenic;villin;Weight Gain

PROJECT_TITLE: Molecular and Epigenetic Control of Wnt/b-catenin-mediated oncogenesis by KDM4B

STUDY_SECTION: MONC

STUDY_SECTION_NAME: Molecular Oncogenesis Study Section[MONC]


NIH_SPENDING_CATS: Bioengineering;Machine Learning and Artificial Intelligence

ORG_CITY: COLLEGE PARK

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MARYLAND, COLLEGE PARK

ORG_STATE: MD

PHR: Project Narrative: T cell receptors and antibodies are exceptionally diverse and capable of engaging broad arrays of antigens, and are of high interest as therapeutics and in the study of immune response to diseases and viruses. My laboratory will generate robust modeling and design frameworks, utilizing large curated datasets of structures assembled by my laboratory and machine learning methods, to accurately predict structures of T cell receptors from sequence, model T cell receptor and antibody antigen recognition, and design T cell receptors and antibodies with desired targeting capabilities. These new tools will be made available to the community, and will be applied to model and design antibodies and T cell receptors of medical and therapeutic interest.

PI_NAMEs: PIERCE, BRIAN G. (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affinity;Algorithms;Antibodies;Antibody Affinity;Antibody Specificity;antigen binding;Antigen Targeting;Antigens;Area;Benchmarking;Code;Collaborations;Communities;Complex;Computational Biology;Data;Data Set;Databases;deep learning;design;Disease;Docking;flexibility;Immune;Immune response;Immunoglobulins;Immunologic Receptors;Immunological Models;improved;interest;Knowledge;Laboratories;Lead;machine learning method;Medical;Methods;Modeling;Molecular Conformation;Peptide/MHC Complex;prediction algorithm;Resolution;Specificity;Structure;T-cell diversity;T-Cell Receptor;Therapeutic;tool;Update;Virus;web server;Work

PROJECT_TITLE: High resolution modeling and design of immune recognition


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Data Science;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: RALEIGH

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: NORTH CAROLINA STATE UNIVERSITY RALEIGH

PHR: Antimicrobial resistance and Clostridioides difficile infections are important public health threats caused by the use of antibiotics. Interactions among resistances and among pathogens influence pathogen burden and effectiveness of the interventions against resistant pathogens. We will develop quantitative methods to harness information on resistance interactions from surveillance data and to evaluate resistance interactions using computational models to design and evaluate interventions.

PI_NAMEs: LANZAS, CRISTINA  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: Address;Antibiotics;Antimicrobial Resistance;antimicrobial resistant pathogen;Biomedical Research;Clostridium difficile;Collection;Complex;Computer Models;Data;data modeling;data pipeline;data streams;design;Diagnostic;Discipline;Effectiveness of Interventions;Epidemiology;Genotype;health care settings;Heterogeneity;Infection;Infectious Diseases Research;Intervention;Joints;Laboratories;Medical Records;Metadata;Methods;Modeling;Molecular Biology;Multi-Drug Resistance;open source;pathogen;Pathway interactions;Pattern;Pharmaceutical Preparations;Phenotype;phenotypic data;Public Health;Research Activity;Resistance;Risk Factors;Source;surveillance data;System;Time;tool;transmission process;Vaccination;Visualization;web site

PROJECT_TITLE: Analytical pipelines for data and model integration: finding informed pathways for antimicrobial resistance control

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-E(55)R]


NIH_SPENDING_CATS: Genetics;Mental Health;Sleep Research

ORG_CITY: HANOVER

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Circadian biological clocks work in all cells of the human body to regulate access to the genome, metabolism, development, and cell division. By studying cells of a fungus, as well as cells of mice and humans, we can understand how this circadian clock control works, how jet lag happens, and how clock malfunction and shift work contribute to diseases like diabetes, cancer, and mental illness.

PI_NAMEs: DUNLAP, JAY C. (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Address;Architecture;Biochemistry;Biological;Biological Clocks;cell behavior;Cell division;Cells;circadian;circadian pacemaker;Circadian Rhythms;Compensation;Complement;computerized tools;Development;Diabetes Mellitus;Disease;Dissection;Elements;Environment;Eukaryota;Feedback;Functional disorder;fungus;Gene Expression;Genetic;Genetic Transcription;Genome;Genomics;Goals;Human;Human body;informatics tool;Jet Lag Syndrome;Language;Lead;Light;Malignant Neoplasms;Mammalian Cell;Mammals;Mental disorders;Mental Health;Mental Processes;Metabolic Diseases;Metabolism;Modeling;Molecular;Mus;Neurospora;New Territories;Nutritional;Organism;Phosphorylation;physical conditioning;Physiological Processes;Physiology;Prevention;Property;Regulation;Repression;Research;response;Rest;RNA metabolism;Role;shift work;Sleep;spatiotemporal;Structure;Study models;Techniques;Temperature;Time;tool;transcription factor;Translations;virtual;Work

PROJECT_TITLE: Genetic and Molecular Dissection of the Neurospora Clock

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Dystonia;Neurodegenerative;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Isolated adult-onset focal dystonia causes disability and negatively impacts quality of life and employment status; available treatments are limited due to incomplete benefit, invasive application, or poor tolerance. The goal of this study is to better understand the brain mechanisms that contribute to isolated dystonia, which may provide rationale for new treatments. This study is relevant to public health and the NIH’s mission to develop a fundamental knowledge of disease to improve symptomatic relief and reduce the burdens of human disability.

PI_NAMEs: NORRIS, SCOTT ALLEN (contact)

PROGRAM_OFFICER_NAME: SIEBER, BETH-ANNE

PROJECT_TERMS: acetylcholine transporter;Address;Adult;Adult-Onset Dystonias;Affect;Age;Analysis of Variance;Animal Model;Binding;Biochemical;Blepharospasm;Body Regions;Brain;Brain region;Cerebellum;Cervical;Characteristics;cholinergic;Cholinergic Receptors;Clinical;comparison control;comparison group;Control Groups;Corpus striatum structure;Data;Development;disability;Disabling;Disease;Dopamine;Drug Targeting;Dystonia;effective therapy;Employment Status;Focal Dystonias;Functional disorder;Functional Magnetic Resonance Imaging;Future;gene discovery;Genotype;Goals;Heterogeneity;Human;in vivo;innovation;interest;Interneuron function;Interneurons;Knowledge;Larynx;Limb Dystonia;Magnetic Resonance Imaging;Measurement;Measures;Mediating;Methods;Mission;Modeling;Molecular;motor control;Multimodal Imaging;Muscle;network dysfunction;neuroimaging;neuroimaging marker;Neurons;Neurotransmitters;new therapeutic target;novel;Participant;Pathogenicity;Pathway interactions;Persons;Pharmaceutical Preparations;Phenotype;Play;Positron-Emission Tomography;presynaptic;Public Health;Quality of life;radioligand;regional difference;Research;Research Personnel;Research Priority;Rest;Role;Severities;sex;Signal Transduction;Subgroup;symptomatic improvement;System;Testing;Thalamic structure;Therapeutic Intervention;therapeutic target;Translating;United States National Institutes of Health;Upper Extremity;uptake

PROJECT_TITLE: The Role of Striatal Cholinergic Interneurons in Dystonia

STUDY_SECTION: CNN

STUDY_SECTION_NAME: Clinical Neuroscience and Neurodegeneration Study Section[CNN]


NIH_SPENDING_CATS: Aging;Breast Cancer;Cancer;Genetics;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative: The N-terminal methyltransferase NRMT1 plays important roles in cell growth and survival. By combining study of its regulation, physiological substrates, and loss of function phenotypes, we aim to pursue a global approach to developing NRMT1 as a potential therapeutic for human cancers and age-related disorders.

PI_NAMEs: SCHANER-TOOLEY, CHRISTINE E (contact)

PROGRAM_OFFICER_NAME: BARSKI, OLEG

PROJECT_TERMS: age-related disease;Aging;amino group;Bacteria;Binding Proteins;Biochemistry;Biological;Breast Cancer Cell;Cell Compartmentation;cell growth;Cell Survival;Code;Consensus Sequence;DNA;Enzymes;Goals;Growth;Histones;Human;Knock-out;Kyphosis deformity of spine;loss of function;Malignant Neoplasms;Mammals;Methylation;Methyltransferase;migration;Mus;Myosin Light Chains;N-terminal;Pattern;Phenotype;Physiological;Play;Post-Translational Protein Processing;Premature aging syndrome;Process;Proliferating;Proteins;Regulation;Role;skin fibrosis;stem cell fate;Therapeutic;tumorigenesis

PROJECT_TITLE: Expanding the biological roles of N-terminal methylation


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative The proposed research is relevant to public health because the discovery of a histone acetyltransferase, the Ada2-containing (ATAC) complex, that regulates the TAZ/YAP transcriptional program in sarcomas will increase understanding of how the transcriptional programs of TAZ/YAP are activated in various cancers, thus providing additional targets for therapy. For this reason, the proposed research is relevant to the part of the NIH's mission to develop fundamental knowledge to lengthen life and reduce illness.

PI_NAMEs: TANAS, MUNIR  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acetylation;Acetyltransferase;Address;Adolescent;Anchorage-Independent Growth;Automobile Driving;Biological Assay;Cell Line;childhood sarcoma;Chimeric Proteins;ChIP-seq;Co-Immunoprecipitations;Complex;Coupled;Data;Development;Ependymoma;Epigenetic Process;epigenetic regulation;epigenome;Gene Fusion;Genetic;Genetic Enhancer Element;Genetic Screening;Genetic Transcription;Genome;Goals;Hemangioendothelioma;Histologic;Histone Acetylation;histone acetyltransferase;Histones;in vivo;innovation;insight;Kinetics;Knowledge;Life;Malignant Neoplasms;Mass Spectrum Analysis;Medical;metaplastic cell transformation;Mission;mouse model;mutant;Mutation;Nasopharynx Carcinoma;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;novel;Oncogenic;Oncoproteins;Outcome;Pathway interactions;pharmacologic;Play;Primary Neoplasm;programs;Proteins;Proteomics;Public Health;recruit;Regulation;Research;Role;Sarcoma;Signal Transduction Pathway;small hairpin RNA;System;targeted treatment;TAZ gene;Testing;TFE3 gene;therapeutic target;Transactivation;Transcription Coactivator;transcriptome;transcriptome sequencing;Transgenic Organisms;tumor growth;tumor initiation;tumorigenesis;United States National Institutes of Health;validation studies;Xenograft Model;Xenograft procedure

PROJECT_TITLE: Epigenetic modulation of the TAZ-CAMTA1 transcriptional program by the Ada2a-containing histone acetyltransferase complex

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Aging;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Project Narrative Periodontitis causes destruction of the tooth-supporting tissues and its prevalence and severity increases with aging. Del-1 is a secreted homeostatic protein that regulates periodontal inflammation and bone formation, although its expression is diminished in old age. This project investigates the consequences of the aging- related deficiency of Del-1 on periodontal bone regeneration and proposes approaches to improve the regenerative capacity of the periodontal tissue in old age.

PI_NAMEs: HAJISHENGALLIS, GEORGIOS  (contact)

PROGRAM_OFFICER_NAME: VERBRIDGE, SCOTT SPENCER

PROJECT_TERMS: Address;Affect;Age Months;age related;age related changes;aged;Aging;aging related;alveolar bone;Animal Model;Apoptotic;Area;Back;Biological Assay;Biology;bone loss;Bone Regeneration;Bone Tissue;Cells;Chronic;Collaborations;Defect;Development;Disease;Elderly;Endothelial Cells;Endothelium;experimental study;Functional disorder;Genetic;Germany;Homeostasis;Human;human old age (65+);Immune response;Immunity;immunoregulation;Impairment;improved;In Vitro;in vivo;in vivo Model;Inflammation;Inflammatory;insight;Integrins;Intervention Studies;Investments;ITGB3 gene;Knock-out;Leukocytes;Location;Macrophage;MAPK3 gene;Mesenchymal Stem Cells;Modeling;Molecular;Mus;mutant;neutrophil;Neutrophil Infiltration;novel;old mice;osteoblast differentiation;Osteogenesis;osteogenic;osteoprogenitor cell;overexpression;Paper;Pennsylvania;Periodontal Diseases;Periodontal Ligament;Periodontitis;Periodontium;Predisposition;Prevalence;Process;progenitor;Proliferating;Protein Secretion;Proteins;Psychiatry;PTK2 gene;Publications;receptor;recruit;regeneration potential;regenerative;Regenerative capacity;Rejuvenation;repaired;Research;Resolution;RGD (sequence);Role;Severities;Signal Transduction;Source;stem cell niche;stem cell self renewal;stem cells;Testing;Therapeutic;tissue regeneration;tissue repair;Tissues;tool;Tooth structure;transcription factor;Transgenic Organisms;Universities;Work

PROJECT_TITLE: Aging and dysfunction of progenitor niches: Role of Del-1

STUDY_SECTION: CMAD

STUDY_SECTION_NAME: Cellular Mechanisms in Aging and Development Study Section[CMAD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Epilepsy;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because it focuses on understanding neural network mecha- nisms underlying long-term memory impairment in epilepsy and testing closed-loop strategies for ameliorating this impairment. Such strategies offer the potential for a significant advance in addressing cognitive comorbidity in patients with epilepsy, in line with the NINDS mission to use mechanistic knowledge to reduce burden of neurological disease.

PI_NAMEs: GELINAS, JENNIFER  (contact)

PROJECT_TERMS: Address;Affect;Animal Model;Area;Behavioral;Biological Assay;Brain;Brain region;Cognitive;Communication;comorbidity;Confocal Microscopy;Coupling;Data;Development;Electric Stimulation;Electrophysiology (science);Epilepsy;Evaluation;Foundations;Gene Expression;Goals;Hippocampus;Immediate-Early Genes;Immunohistochemistry;Impaired cognition;Impairment;improved;in vivo;Information Storage;innovation;Knowledge;Link;long term memory;Medial;medial temporal lobe;Memory;memory consolidation;Memory impairment;Mission;Modeling;Molecular;molecular marker;molecular scale;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;network dysfunction;neural;neural network;neural patterning;Neurons;novel strategies;novel therapeutic intervention;novel therapeutics;Outcome;Output;Pathologic;Patients;Pattern;Physiological;Play;Population;Prefrontal Cortex;prevent;Prevention;programs;Protocols documentation;Public Health;Rattus;Research;response;restoration;Risk Factors;Rodent;sleep spindle;spatial memory;spatiotemporal;Structure;Synaptic plasticity;targeted treatment;Temporal Lobe Epilepsy;Testing

PROJECT_TITLE: Closed-Loop Modulation of Hippocampal-Cortical Communication in Temporal Lobe Epilepsy

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Neurosciences;Orphan Drug;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Narrative Glioblastoma is a highly heterogeneous and lethal human brain tumor that contains stem-like cells (GSCs) that contribute to tumor initiation, development, growth and resistance to conventional therapies. If successful, the proposed project would provide information on a new REST-miR-124-miR-203 mechanism-based therapeutic approach for stratified High REST-GSC tumor subtype in combination with standard-of-care temozoomide and ionizing radiation. It would also reveal treatment-dependent transcriptome signatures, providing mechanistic information about affected downstream targets and pathways.

PI_NAMEs: MAJUMDER, SADHAN  (contact)

PROGRAM_OFFICER_NAME: KOTLIAROVA, SVETLANA

PROJECT_TERMS: Affect;Biological Assay;Biology;Brain Neoplasms;cancer stem cell;Caring;Characteristics;Clinical;comparison control;conventional therapy;design;Development;exosome;experience;experimental study;Gender;gender difference;Genes;Glioblastoma;Goals;Growth;Homing;Human;In Situ;In Vitro;inhibitor;Intracranial Neoplasms;Ionizing radiation;knock-down;Laboratories;male;Mass Spectrum Analysis;Measures;Mediating;Medulloblastoma;Membrane Proteins;Mesenchymal Stem Cells;Methods;Modeling;Molecular;molecular subtypes;mouse model;Mus;neoplastic cell;Newly Diagnosed;novel;novel therapeutic intervention;Oncogenic;Parents;Pathway interactions;Patient-Focused Outcomes;Patients;Printing;Process;promoter;Property;Proteomics;Publishing;Radiation;Regimen;Repression;Resistance;Rest;small hairpin RNA;standard of care;stem cell exosomes;stem cells;stem-like cell;System;targeted treatment;temozolomide;Testing;Therapeutic;therapeutic target;therapy resistant;Transcription Repressor;transcriptome;transcriptome sequencing;tumor;tumor growth;tumor initiation;Tumor Subtype;Tumor-Derived;tumorigenesis;tumorigenic;Tumorigenicity;VP 16;Women's Group

PROJECT_TITLE: New Therapeutic Approaches for Stratified High-REST GBM Subtype

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Digestive Diseases;Inflammatory Bowel Disease

ORG_CITY: PITTSBURGH

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Inflammatory bowel disease (IBD) affects 1.6—3.1 million Americans and is associated with significant lifetime morbidity as well as a heavy financial burden to society. Our current understanding of the factors that initiate and propagate inflammatory changes within the intestine is limited. The current proposal is designed to investigate how abnormalities in mitochondrial function and cellular metabolism within the intestinal epithelium contribute to disease in the hopes of identifying novel therapeutic strategies for IBD aimed at improving mitochondrial health in the intestine.

PI_NAMEs: MOLLEN, KEVIN P (contact)

PROGRAM_OFFICER_NAME: SENGER, STEFANIA

PROJECT_TERMS: Acute;Affect;American;Animal Model;Antioxidants;Autophagosome;Binding;Biogenesis;Biological Markers;Chemicals;Childhood;Communication;Deacetylation;Defect;design;Diabetes Mellitus;Diagnosis;Disease;Disease Outcome;DNA Damage;DNA Repair Enzymes;Down-Regulation;Event;experimental study;Financial Hardship;Functional disorder;Gene Expression;Genes;glycogen synthase kinase 3 beta;Goals;gut inflammation;Health;Human;human tissue;improved;improved outcome;Incidence;Inflammation;Inflammatory;Inflammatory Bowel Diseases;Injury;Institution;intestinal epithelium;intestinal injury;Intestines;Investigation;Knockout Mice;Mediating;Metabolic;metabolic profile;Metabolism;metabolomics;Mitochondria;mitochondrial dysfunction;Mitochondrial Proteins;Modeling;monolayer;Morbidity - disease rate;murine colitis;Mus;Neurodegenerative Disorders;nicotinamide-beta-riboside;novel therapeutic intervention;Oxidative Phosphorylation;Pathogenesis;patient subsets;Patients;Peptide Initiation Factors;pharmacologic;Physiological;PPAR gamma;Predisposition;prevent;Prevention;Process;Proteins;Quality Control;response;restoration;Sentinel;Severity of illness;Signal Transduction;SIRT1 gene;Societies;Sum;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;transcriptomics;Ulcerative Colitis;Work

PROJECT_TITLE: Mitonuclear Communication During the Pathogenesis of Inflammatory Bowel Disease

STUDY_SECTION: GMPB

STUDY_SECTION_NAME: Gastrointestinal Mucosal Pathobiology Study Section[GMPB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Coronaviruses;Networking and Information Technology R&D (NITRD)

ORG_CITY: BLACKSBURG

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Project Narrative. Molecular modeling and simulations are indispensable tools in biomedical science and the drug discovery process. The proposed research will significantly enhance the capabilities of these tools and the likelihood of important discoveries by making the tools more accurate and efficient.

PI_NAMEs: ONUFRIEV, ALEXEY VLAD (contact)

PROGRAM_OFFICER_NAME: NGUYEN, HAN

PROJECT_TERMS: 2019-nCoV;Acceleration;ACE2;Address;Affinity;Algorithms;Amino Acids;Area;base;Binding;Binding Proteins;Biological Process;Biomedical Research;Cells;Chemicals;Code;Communities;Complex;Computer software;computerized tools;conventional therapy;Coupling;design;DNA;Docking;Drug Design;drug development;drug discovery;electric dipole;experimental study;Face;Free Energy;future pandemic;Gene Expression;Goals;Head;Health;High Performance Computing;Human;Hydration status;improved;in silico;Incentives;Individual;Industry Standard;innovation;Ligands;Methods;Modeling;models and simulation;Modernization;Molecular;Molecular Conformation;molecular dynamics;molecular modeling;mutant;Mutation;next generation;Noise;novel;novel strategies;pandemic disease;pandemic response;Physics;Process;Property;protein folding;Proteins;Protocols documentation;Readiness;receptor;receptor binding;Research;Sampling;SARS-CoV-2 genome;Science;screening;Signal Pathway;simulation;small molecule;Solvents;Speed;structural biology;Structure;technology research and development;theories;tool;Translating;Virus;Water;web-based tool

PROJECT_TITLE: Next generation implicit solvation for atomistic modeling

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


NIH_SPENDING_CATS: Aging;Atherosclerosis;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

ORG_STATE: NY

PHR: The proposed research is relevant to the public health because CAD remains a top determinant of mortality, and represents a major economic burden based on 2017 report of AHA. From this study, we will understand how alteration of a class of lipids, called sphingolipids, impact the development and progression of coronary atherosclerosis, providing a framework for target and drug discovery directed to ameliorate vascular inflammation in CAD and other CV conditions.

PI_NAMEs: DI LORENZO, ANNARITA  (contact)

PROGRAM_OFFICER_NAME: LIU, LIJUAN

PROJECT_TERMS: acetyl-LDL;Address;Anabolism;aortic valve;Apolipoprotein E;Apoptosis;Arterial Fatty Streak;Atherosclerosis;Binding;Biological Process;Biology;Cardiovascular Physiology;Cardiovascular system;Carotid Arteries;Cause of Death;cell growth;Cell Physiology;Cell Survival;Cells;Ceramides;Cholesterol;cholesterol biosynthesis;Cholesterol Esters;Clinical;Complex;Coronary;Coronary Arteriosclerosis;coronary lesion;Data;Development;Disease;Disease Progression;Down-Regulation;drug discovery;Economic Burden;Endoplasmic Reticulum;Endothelium;Enzymes;Event;Foam Cells;G-Protein-Coupled Receptors;Genetic;genetic approach;Genetic Transcription;Goals;Grant;Health;Heart failure;Heterogeneity;Human;human disease;Hypertension;Immune;immune function;Inflammation;Inflammatory;innovation;insight;Lesion;Lipids;Macrophage;Mammals;Mediator;Membrane;Membrane Proteins;Metabolic Pathway;Metabolism;metabolomics;Modeling;Molecular;Mortality Determinants;mouse model;Mus;Myocardial Infarction;Names;novel;Operative Surgical Procedures;oxidized low density lipoprotein;Pathway interactions;Pharmaceutical Preparations;pharmacologic;Phenotype;Phosphorylation;Plasma;Play;Population;Predisposition;Process;Protein phosphatase;Protein Phosphatase 2A Regulatory Subunit PR53;Public Health;Regulation;Reporting;Research;Role;Rupture;serine palmitoyltransferase;Signal Transduction;Signaling Molecule;single-cell RNA sequencing;Sphingolipids;sphingosine 1-phosphate;Testing;Therapeutic;therapeutic development;therapeutic target;TNF gene;Up-Regulation;vascular inflammation

PROJECT_TITLE: SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSION

STUDY_SECTION: AICS

STUDY_SECTION_NAME: Atherosclerosis and Inflammation of the Cardiovascular System Study Section[AICS]


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

PHR: The Research Experience in Autism for College and High School students (REACH) is an eight-week pipeline summer course for minorities and underrepresented students interested in the field of neuroscience. REACH is an immersive, team-based and peer-mentoring program that provides students with research training in Autism Spectrum Disorders complemented with lecture, clinical and career development instruction. REACH’s long- term goal is to increase access and retention of underrepresented minorities into the neuroscience/biomedical field and their representation and decision-making influence within our nation.

PI_NAMEs: ALARCON, JUAN MARCOS (contact);LIBIEN, JENNY

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Address;autism spectrum disorder;Basic Science;Biology;Biomedical Research;Brain;career;Career Choice;career development;Clinical;clinical development;cohort;college;Color;Communities;cultural competence;Decision Making;Dedications;Disparity;Diverse Workforce;Doctor of Philosophy;doctoral student;education pathway;Educational process of instructing;effectiveness evaluation;effectiveness research;Enrollment;Evaluation;experience;Extramural Activities;Faculty;Feedback;Funding;Future;Goals;graduate student;health disparity;Health Sciences;high school;High School Student;higher education;impression;Individual;Infrastructure;Instruction;interest;Knowledge;Leadership;lectures;Life;Medical;Medical Students;meetings;Mental Health;Mentors;Minority;minority student;Motivation;Needs Assessment;Nervous System Disorder;Neurodevelopmental Disorder;Neurosciences;Outcome;Participant;peer coaching;Physicians;Population Heterogeneity;programs;Questionnaires;recruit;Research;Research Personnel;Research Training;skills;STEM field;student mentoring;student participation;Students;summer program;summer research;summer student;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Students;Universities;university student;Visit

PROJECT_TITLE: REACH Pipeline Summer Research Experience for Minority and Underrepresented High School and Undergraduate Students


NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

PHR: PROJECT NARRATIVE There are numerous ultra-small size bacteria in our bodies called TM7 that live on the surface of other typically known and studied bacteria, making them difficult to study in the laboratory. These bacteria are linked to periodontal disease in the oral cavity and various inflammatory diseases throughout the body, but when it comes to their role in these diseases, we have an extremely limited understanding. Our research is focused on systematically examining the pathogenesis of these ultra-small bacteria with its host bacteria, thereby contributing to the fundamental knowledge about these newly recognized bacteria in disease.

PI_NAMEs: BOR, BATBILEG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Actinobacteria class;Actinomyces;Address;Animal Model;Bacteria;bacterial genetics;Behavior;Biological Assay;Biological Process;Cell Communication;Cell Size;Cell Survival;Cells;Characteristics;chronic inflammatory disease;Classification;Collaborations;Communities;Cultured Cells;cytokine;Data;design;Development;Disease;dysbiosis;Epithelial Cells;Epithelium;Eukaryotic Cell;Exposure to;Funding;Gene Expression Profile;Genes;Genetic;Genome;Gingiva;Grant;Health;Human;Immune;Immune response;Immunologics;improved;In Vitro;in vivo;Infection;Inflammation;Inflammatory;inflammatory bone loss;Inflammatory Response;Innate Immune Response;Investigation;Knowledge;Laboratories;Libraries;Life Style;Ligature;Link;macromolecule;Macrophage;Measures;member;metatranscriptomics;Methods;microbial community;Modeling;mouse model;Mucous Membrane;Mus;neutrophil;next generation sequencing;novel;opportunistic pathogen;Oral;Oral cavity;oral microbiome;pathobiont;Pathogenesis;pathogenic bacteria;Pathogenicity;Patients;Periodontal Diseases;Periodontitis;Phagocytosis;Play;polymicrobial disease;Radiation;Regulation;Research;response;Role;Site-Directed Mutagenesis;Surface;System;Taxonomy;Testing;tool;transcriptome;Virulence Factors;virulence gene

PROJECT_TITLE: Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory Diseases


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: CORAL GABLES

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Our selection of foods we consume is governed in large part by taste pathways in the periphery (sweet, salty, sour, etc). However, there is a paucity of information about the molecular identities of afferent sensory neurons that process taste signals and transmit these signals to the brain. Understanding how basic tastes are encoded by sensory neurons whose molecular profiles are known is key for understanding diet selection and making rational choices of what we eat.

PI_NAMEs: CHAUDHARI, NIRUPA ;ROPER, STEPHEN D. (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Afferent Neurons;Auditory;biomarker validation;Brain;Brain Stem;Categories;Cell Communication;Cell Nucleus;cell type;Cells;Cephalic;Chromium;Code;combinatorial;Data;designer receptors exclusively activated by designer drugs;Detection;Diet;Eating;Electrophysiology (science);Entropy;Feeding behaviors;food consumption;Food Selections;Funding;Ganglia;Gene Expression Profile;Genetic;Genomics;glucose tolerance;Goals;Image;in vivo;Insulin;Label;Laboratories;Lasers;Measures;Mediating;Methods;Molecular;molecular marker;Molecular Profiling;Mouse Strains;Mus;Neural Pathways;Neurons;Noise;nutrition;Pathway interactions;Phase;Physiological;Process;prototype;Reflex action;response;Reticular Formation;Retina;Retinal Ganglion Cells;Signal Transduction;single-cell RNA sequencing;somatosensory;Stimulus;Structure of geniculate ganglion;System;Taste Bud Cell;Taste Buds;Taste Perception;taste stimuli;Testing;transcriptome;transmission process;Visual

PROJECT_TITLE: Functions of gustatory afferent neuron types.

STUDY_SECTION: CSS

STUDY_SECTION_NAME: Chemosensory Systems Study Section[CSS]


ORG_CITY: LA JOLLA

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project narrative: The proposed research will investigate the functional roles of electrostatic interactions in the regulation of transcription and translation in bacteria and their biofilm communities, which due to their notorious tolerance to antibiotics pose a critical public health threat. In particular, we aim to establish a new paradigm for understanding how electrostatic interactions in bacteria can regulate cell fate decisions, such as the entry into, and exit from dormancy, which is the major cause of bacterial tolerance to antibiotics.

PI_NAMEs: SUEL, GUROL MEHMET (contact)

PROJECT_TERMS: Address;Affect;Antibiotic Resistance;antibiotic tolerance;Bacteria;Bacterial Model;Binding;biological adaptation to stress;Biological Models;Biological Process;Biology;cell community;Cell Physiology;Cells;Charge;Covalent Interaction;Cytoplasm;Devices;Electrostatics;experimental study;Genetic Transcription;Ionic Strengths;Ions;Measurement;Molecular;Physics;Play;polymicrobial biofilm;programs;Public Health;Regulation;Research;Role;stress tolerance;Techniques;Transcriptional Regulation;Translations;Work

PROJECT_TITLE: Charge matters: Pursuing the most common, and least understood molecular interactions in cells


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

ORG_CITY: BALTIMORE

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Synaptic connections between neurons are required for all human behavior, and new experiences are encoded in brain circuits by altering their performance. This project aims to assess previously unexplored features of synapses that may allow their performance to be adjusted in heretofore unexpected ways, and will thus help understand the biological basis of memory formation. Further, because mental illness frequently arises from aberrant synapse function, these experiments will help determine the origin and potential treatments for diseases including schizophrenia and autism.

PI_NAMEs: BLANPIED, THOMAS A (contact)

PROGRAM_OFFICER_NAME: DRISCOLL, JAMIE DANIELLE

PROJECT_TERMS: Actins;Action Potentials;Acute;addiction;Address;Adhesions;Alzheimer's Disease;AMPA Receptors;Architecture;autism spectrum disorder;Behavior;Binding;biochemical tools;Biological;Brain;brain tissue;Cell Adhesion Molecules;Cells;Complex;Cytoskeleton;Data;density;depolymerization;Disease;Electroporation;Elements;Event;Evoked Potentials;experience;experimental study;extracellular;Extracellular Domain;Face;Funding;Genetic;genetic regulatory protein;Glutamate Receptor;Glutamates;Goals;Grant;Human;imaging modality;in utero;in vivo;Individual;insight;Knock-out;Light;Link;Maintenance;Maps;Mediating;Memory;Mental Depression;Mental disorders;Methodology;Methods;Modeling;Molecular;molecular imaging;Movement;nano;nanocluster;nanometer resolution;nanopattern;nanoscale;Nanostructures;neuroligin 1;Neurons;Neurosciences;neurotransmitter release;Optics;Outcome;Pattern;Peptide Hydrolases;Performance;pharmacologic;Physiological;Physiology;Play;polymerization;Polymers;Positioning Attribute;postsynaptic;presynaptic;Probability;Process;protein complex;Proteins;Publishing;Reagent;receptor;recruit;Resolution;Role;Sampling;Scaffolding Protein;Schizophrenia;Signal Transduction;single molecule;Site;Slice;spatiotemporal;Structure;superresolution imaging;Synapses;Synaptic Cleft;synaptic function;Synaptic plasticity;Synaptic Potentials;Synaptic Receptors;Synaptic Transmission;Technology;Testing;Time;tool;Vesicle;Visualization;Work

PROJECT_TITLE: Internal Dynamics of the Postsynaptic Density


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Reducing the overall incidence of and racial/ethnicity disparities in HIV and other sexually transmitted infections (STI) among men who have sex with men in the United States will require comprehensive PrEP care designed for the heterogeneity of PrEP users across different epidemiological contexts. The STIRRUP Study will directly generate prevention science to support clinical practice and policy decisions on STI screening within PrEP care for men who have sex with men (MSM) in the United States.

PI_NAMEs: JENNESS, SAMUEL  (contact)

PROGRAM_OFFICER_NAME: SCOTT-SHELDON, LORI ANN JENNIFER

PROJECT_TERMS: Acceleration;Accounting;Address;African American;AIDS prevention;Behavioral;Big Data;black men who have sex with men;Black race;Boston;burden of illness;Caring;Chlamydia;Cities;Clinical;clinical practice;condoms;Continuity of Patient Care;cost;cost effectiveness;cost estimate;Data;data integration;data streams;demographics;design;Detection;Development;Diagnosis;Disease;disparity reduction;Economic Models;Economics;Electronic Health Record;Epidemic;Epidemiology;epidemiology study;Ethics;ethnic disparity;Ethnic Origin;Etiology;falls;Genitourinary system;geographic difference;Geography;Goals;Gonorrhea;Guidelines;health care settings;Health Policy;Heterogeneity;high risk men;HIV;improved;Incidence;Infection;infection burden;infection rate;Intervention;Link;mathematical model;men;men who have sex with men;men's group;Mental Health;Modeling;Modernization;Network-based;Pattern;Pharyngeal structure;Policies;Population;pre-exposure prophylaxis;prevent;Prevention;prevention service;Privatization;programs;Public Health;Race;racial disparity;Recommendation;Recording of previous events;Rectum;Resources;response;Risk;routine screening;scale up;Science;screening;Services;Sex Behavior;sexual risk behavior;Sexually Transmitted Diseases;Shapes;Site;STI prevention;success;Swab;Syphilis;Testing;theories;transmission process;Uncertainty;United States;Unsafe Sex;Variant;Visit

PROJECT_TITLE: STI Response and Recommendations Under PrEP (STIRRUP)

STUDY_SECTION: PPAH

STUDY_SECTION_NAME: Population and Public Health Approaches to HIV/AIDS Study Section[PPAH]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: Veterans Affairs

ORG_NAME: VETERANS HEALTH ADMINISTRATION

PHR: Stroke is a common condition that causes weakness of one side of the body but it is difficult to predict how much recovery happens, where and when rehabilitation should happen, and what ultimate living situation is best. There is as potential for wearable devices (such as activity monitors) to help the medical team better make decisions about rehabilitation and provide patients and their families with information about recovery. We propose to test a set of wearable devices that measure movement, muscle activation, and sweating (which is a measure of effort and stress,) in veterans who are admitted to the hospital for stroke. The data from these wearables will be analyzed and compared to standard tests of function, using machine learning techniques. We expect that movement during daily and even nighttime activity will provide useful information that will enable better decision-making in cases of new strokes.

PI_NAMEs: WITTENBERG, GEORGE F. (contact)

PROJECT_TERMS: Acceleration;Activities of Daily Living;Acute;acute stroke;Address;Admission activity;Affect;Affective;Algorithms;Area;arm;arm function;Autonomic nervous system;Biological Markers;Clinical;Computer software;cost;Data;Data Collection;Decision Making;design;Diagnosis;Dimensions;disability;Electromyography;Evaluation;experience;Family;functional status;Future;Galvanic Skin Response;Goals;Home;Hospitalization;Hospitals;Hour;Impairment;improved;Individual;inpatient service;Inpatients;insight;kinematics;Knowledge;Life;lifetime risk;Machine Learning;Manufacturer;Measurement;Measures;Medical;Modality;Monitor;Motivation;Motor;motor impairment;Movement;multimodality;Muscle;Outcome;Outcome Assessment;Patients;personalized intervention;personalized medicine;Physiological;post stroke;Productivity;Prognosis;psychologic;Psychological Factors;Quality of life;Recovery;Rehabilitation therapy;Research Project Grants;response;Sampling;sensor;Series;Services;Side;Stress;Stroke;stroke patient;stroke rehabilitation;stroke risk;stroke survivor;stroke therapy;Surface;Sweating;Task Performances;Techniques;Testing;Therapy Evaluation;Time;Upper Extremity;usability;Veterans;wearable data;wearable device;wearable sensor technology

PROJECT_TITLE: Multimodal Guidance towards Precision Rehabilitation to Improve Upper Extremity Function in Stroke Patients

STUDY_SECTION: RRDS

STUDY_SECTION_NAME: Rehabilitation Research and Development SPiRE Program[RRDS]


ORG_CITY: ANN ARBOR

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Project Narrative Herein, we will utilize photo- and electrochemical single electron transformations to gain access to biologically relevant molecules. Through the synthesis of novel chemical building blocks, the generation of valuable bond disconnections, and the merger of complementary reaction platforms, this proposal provides innovations in efficiency and economy which are directly translatable to the discovery of small molecule therapeutics.

PI_NAMEs: STEPHENSON, COREY  (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Free radical strategies for bioactive molecule synthesis

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project narrative The intestinal lining consists of different types of cells that are specialized to absorb nutrients and water, produce mucus or otherwise contribute to a functional intestine. We propose that tuft cells, a type of these lining cells, are specialized to recognize different types of infection such as parasitic or bacterial infection, and orchestrate the immune response accordingly. In our experiments we will elucidate the unknown role of tuft cells in bacterial infection, which will help to understand how intestinal inflammation is triggered and lay the foundation for better treatment of intestinal infectious and inflammatory disease.

PI_NAMEs: RAUCH, ISABELLA  (contact)

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: Actins;Address;Affect;Anti-Bacterial Agents;antimicrobial;Antiparasitic Agents;Attenuated;Bacterial Gastroenteritis;Bacterial Infections;Biology;CASP1 gene;Cell Communication;Cell Line;Cell model;cell type;Cells;Cellular biology;co-infection;Collaborations;Communicable Diseases;Communication;Complement;cysteinyl-leukotriene;cytokine;Data;Detection;Dinoprostone;Disease;Dopamine D2 Receptor;Eicosanoids;enteric infection;Enterocytes;Epithelial Cells;Epithelium;Evolution;experimental study;Exposure to;Foundations;Gastroenteritis;gastrointestinal;gastrointestinal infection;Genes;gut inflammation;Health;helminth infection;Hormones;IL18 gene;Immune;Immune response;Immune signaling;Immune system;Immunity;immunological status;immunoreaction;immunoregulation;In Vitro;in vivo;in vivo Model;Individual;Infection;Inflammasome;Inflammatory;Inflammatory Response;innate immune sensing;Interleukin-13;interleukin-22;Interleukin-5;intestinal epithelium;Intestines;Invaded;Laboratories;Lamina Propria;lipid mediator;Lymphocyte;Lymphoid;Lymphoid Cell;Mediating;microorganism;Modeling;mouse Cre recombinase;mouse model;Mucous body substance;Mus;Nippostrongylus;nutrient absorption;Oregon;Parasites;Parasitic infection;pathogen;Pathogen detection;pathogenic bacteria;Pathway interactions;Peptide Hydrolases;prevent;Prostaglandin D2;Prostaglandins;Publishing;Reaction;receptor expression;Regenerating islet derived protein 3-Gamma;Reporting;Resistance;response;Role;Salmonella;Salmonella typhimurium;Science;sensor;Sentinel;Shapes;Shigella Infections;Signal Transduction;single-cell RNA sequencing;Small Intestines;Sorting;Source;Systemic infection;Testing;Tissues;Universities;Washington;Water

PROJECT_TITLE: The role of the tuft cell inflammasome in infection

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative Antiretroviral therapy (ART) is highly successful in suppressing viral replication and preventing disease progression, however, it does not eradicate HIV. Standard ART does not fully restore health or a normal immune status in people living with HIV (PLWH) and co-morbidities such as cardiovascular disease and cognitive impairment may occur. Efforts to identify strategies to eradicate or induce treatment-free long-term HIV remission are critical.

PI_NAMEs: CASKEY, MARINA  (contact)

PROGRAM_OFFICER_NAME: JANCI, ELIZABETH WONDERLICH

PROJECT_TERMS: Acceleration;adaptive immune response;Adult;Aftercare;Amino Acids;Animal Model;Animal Testing;Animals;anti-CD20;Antibodies;antibody-dependent cell cytotoxicity;Antibody-Dependent Enhancement;Antigen Presentation;Antigen-Antibody Complex;Antigens;antiretroviral therapy;B-Cell Lymphomas;base;Binding;Binding Sites;Biological Assay;Biological Products;BLR1 gene;cancer cell;Cardiovascular Diseases;CD8-Positive T-Lymphocytes;Cells;Cellular Immunity;Clinical Research;comorbidity;cytotoxic;Development;Disease Progression;Disease remission;Dose;Drug Kinetics;Fc domain;Fostering;Frequencies;Genetic;Genetic Transcription;Half-Life;Health;healthy volunteer;HIV;HIV Envelope Protein gp120;HIV-1;Humoral Immunities;Immune;Immune response;Immune system;Immunity;immunological status;Immunologics;immunoregulation;Immunotherapy;Impaired cognition;improved;In Vitro;Individual;Indolent;Infection;Infusion procedures;Innate Immune Response;Interleukin-15;Interruption;Intervention;lymph nodes;Macaca;Measures;Mediating;Modeling;Monoclonal Antibodies;Mus;Mutation;Natural Killer Cells;neutralizing antibody;Non-Hodgkin's Lymphoma;nonhuman primate;novel;Patients;peripheral blood;Persons;Phase I/II Clinical Trial;Pilot Projects;Plasma;prevent;Proliferating;Property;Provirus Integration;Qualitative Methods;recruit;Refractory;Relapse;response;rituximab;Safety;simian human immunodeficiency virus;SIV;success;T cell response;Testing;Time;trafficking;V3 Loop;Vaccines;Variant;Viral;Viral Physiology;Viral reservoir;Viremia;Virus;Virus Diseases;Virus Replication

PROJECT_TITLE: Immunologic control of HIV-1 through combination bNAbs and biologics.


ORG_CITY: CHAMPAIGN

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Emerging and recalcitrant fungal infections, especially in immunocompromised patients, have significantly risen in recent years. As no licensed fungal vaccines are available, our work aims to uncover the basis of fungal vaccine immunity, and identity of a protective surface marker that has profound implications of T-cell based vaccine-efficacy. Our work is of translational in nature, and will serve as a guide to other fungal vaccine platforms tailored for immunocompromised individuals.

PI_NAMEs: NANJAPPA, SOMASHEKARAPPA GOWDA (contact)

PROGRAM_OFFICER_NAME: RITCHIE, ALEC

PROJECT_TERMS: Acceleration;Adjuvant;Adopted;Adoptive Transfer;anti-fungal agents;Antigen-Presenting Cells;Apoptosis;Bacterial Infections;base;Blastomyces;Bone Marrow;CD4 Positive T Lymphocytes;CD43 molecule;CD8-Positive T-Lymphocytes;Cells;Chimera organism;congenic;Coupled;CRISPR/Cas technology;Cross Presentation;Cryptococcus;cytokine;Dendritic cell activation;Dendritic Cells;design;Development;Diagnosis;Differentiation Antigens;E-Selectin;Elements;experimental study;fungal pneumonia;Fungal Vaccines;fungus;Genes;Genetic Crosses;glycosylation;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Histoplasma;Homeostasis;IL17 gene;Immune;Immunity;Immunocompromised Host;immunodeficiency;immunopathology;in vivo;Individual;Interferon Type II;Interleukin-2;interleukin-22;Knockout Mice;Licensing;Lung;Lymphopenia;Marker Vaccines;Mediating;Memory;metabolic fitness;Monoclonal Antibodies;Morbidity - disease rate;mortality;mouse model;Mus;mutant;Mutant Strains Mice;Mycoses;Nature;novel;novel vaccines;Pathology;phenotypic biomarker;Pneumocystis;Population;Populations at Risk;PPBP gene;Predisposition;Preventive measure;Proliferating;recruit;Reporter;Resistance;response;Risk;Role;Seminal;Signal Transduction;Subunit Vaccines;Surface;Surface Antigens;T cell response;T memory cell;T-Lymphocyte;TC1 Cell;Techniques;TNF gene;Toxic effect;Vaccination;vaccine access;vaccine efficacy;vaccine evaluation;vaccine platform;vaccine response;Vaccines;vaccinology;Virus Diseases;Work

PROJECT_TITLE: Immunity against fungal infections

STUDY_SECTION: VMD

STUDY_SECTION_NAME: Vaccines Against Microbial Diseases Study Section[VMD]