NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Prevention;Urologic Diseases

ORG_DEPT: UROLOGY

PHR: Project Narrative: In patients with urinary stone disease, several knowledge gaps persist regarding the impact of fluid therapy in preventing stone recurrence, and the optimal care after insertion of a ureteral stent (a thin tube inserted into the ureter to prevent obstruction of the urine flow from the kidney). This application will address these gaps by assessing the effectiveness and safety of new behavioral strategies to increase urine fluid intake, and evaluating factors contributing to discomfort following stent insertion, with the ultimate goal of improving patient care.

PI_NAMEs: AL-KHALIDI, HUSSEIN ;SCALES, CHARLES D (contact)

PROGRAM_OFFICER_NAME: MULLINS, CHRISTOPHER V

PROJECT_TERMS: Address;Adherence;Adolescent;Adult;arm;associated symptom;Behavior Therapy;Behavioral;Biological;Blood;Caring;Child;Childhood;Clinic;Clinical;clinical center;Clinical Research;cohort;Collection;Communities;cost;COVID-19;Data;Data Analyses;Data Collection;Deposition;design;Disease;Effectiveness;effectiveness evaluation;Endocrinologist;Enrollment;Ensure;evaluation/testing;Event;experience;financial incentive;Fluid Therapy;follow-up;Foundations;Funding;Future;Goals;Health;health care service utilization;Hydration status;improved;Individual;innovation;insight;Intake;Intervention;Interview;Investigation;Kidney;Kidney Calculi;Knowledge;Lifting;Liquid substance;Manuscripts;Measures;Medical;Medicine;Modification;Morbidity - disease rate;multidisciplinary;National Institute of Diabetes and Digestive and Kidney Diseases;novel;observational cohort study;Obstruction;Output;Pain;Pamphlets;Participant;participant enrollment;Patient Care;Patient Recruitments;Patients;Pediatric Hospitals;Peer Review;Pennsylvania;Perioperative complication;Philadelphia;Plasma;Postoperative Period;Preparation;Prevalence;prevent;Prevention;primary endpoint;Problem Solving;Procedures;programs;prospective;Prospective, cohort study;Protocols documentation;Provider;Psychosocial Assessment and Care;Public Health;Publications;Questionnaires;radiologist;Randomized;randomized, clinical trials;Recommendation;recruit;Recurrence;Recurrent disease;Regimen;Reporting;repository;Research;Research Design;Research Institute;Research Personnel;Resources;Safety;Sampling;Scientist;Sensory;Serum;Societies;Stents;Structure;success;Symptoms;Texas;therapy design;Thinness;Time;Touch sensation;treatment arm;Tube;Universities;Ureter;Ureteroscopy;urinary;Urinary Calculi;Urine;urologic;Urologist;Visit;Washington;Water;web site;webinar;Whole Blood

PROJECT_TITLE: Urinary Stone Disease Research Network: Scientific Data Research Center


ADMINISTERING_IC: MH

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Services;Mental Health;Mental Illness;Social Determinants of Health

ORG_CITY: TAMPA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Project Narrative In response to large numbers of senior center clients who suffer untreated depression and the dearth of geriatric mental health providers, we have simplified Behavioral Activation to be delivered by lay volunteers (“Do More, Feel Better”; DMFB). The focus of Behavioral Activation is to guide clients to reengage in daily pleasant and rewarding activities, and reduce depressive symptoms. If we can show that the lay delivery model has positive impact in comparison to MSW-delivered Behavioral Activation, we will have identified an effective intervention that can be used by a large untapped workforce of older adult volunteers across the nation.

PI_NAMEs: GUM, AMBER M (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Address;Aging;Area;Behavioral;Characteristics;Client;Clinical;Clinical Trials;clinically significant;Communities;community setting;cost;Dementia;Depressed mood;Depression screen;depressive symptoms;Diagnostic;disability;effective intervention;Effectiveness;effectiveness testing;effectiveness trial;Eligibility Determination;ethnic diversity;experience;Funding;Geography;geriatric mental health;Health;Health Personnel;improved;Individual;Infrastructure;Intervention;Label;Light;Mental Depression;Mental disorders;Mental Health;Modeling;National Institute of Mental Health;New York City;non-demented;Nutritional;older adult;Older Population;Outcome;Participant;Population;practice setting;Provider;Psychoses;psychosocial;Randomized;randomized effectiveness trial;Recreation;recruit;Reporting;Resources;response;Rewards;Safety;Sample Size;satisfaction;Service setting;Services;Severities;Site;skills;social;sociodemographic factors;sociodemographics;Supervision;Testing;Time;volunteer;Vulnerable Populations;Work;World Health Organization Disability Assessment Schedule

PROJECT_TITLE: 3/3 Lay-delivered Behavioral Activation in Senior Centers


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: BOSTON

ORG_NAME: TUFTS MEDICAL CENTER

ORG_STATE: MA

PHR: New targeted drugs have dramatically improved cancer survival however, many such cancer treatments have cardiovascular side effects. Specifically, new drugs for leukemia have improved life expectancy to match people without cancer but a higher than normal risk of heart attack and stroke has emerged in these leukemia survivors. This proposal uses multiple innovative technologies to understand how these new cancer drugs may contribute to heart attack and stroke and to develop ways to predict those side effects before exposing patients to the risk. In addition, we test new methods to identify co-treatments that might alleviate the heart disease risk in these cancer survivors.

PI_NAMEs: JAFFE, IRIS Z (contact)

PROGRAM_OFFICER_NAME: CHARETTE, MARC F

PROJECT_TERMS: 3-Dimensional;Acute;Address;Adhesions;Adverse event;Antidotes;Antineoplastic Agents;Apolipoprotein E;artery occlusion;Atherosclerosis;Biological Assay;Biomedical Engineering;Blood Cells;Blood flow;Blood Platelets;Blood Vessels;cancer care;cancer survival;Cancer Survivor;cancer therapy;Cardiotoxicity;Cardiovascular system;Caring;Cell Communication;cell injury;Cell Physiology;Chronic Disease;Chronic Myeloid Leukemia;Dasatinib;Data;Development;Disease;Drug Approval;Drug toxicity;Endothelial Cells;Endothelium;Exposure to;Functional disorder;Generations;healing;heart disease risk;hemodynamics;Human;Human Engineering;human model;Imatinib;Impairment;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Inflammation;Inflammatory;Injury;innovation;innovative technologies;intravital microscopy;Ischemia;kinase inhibitor;Knockout Mice;Knowledge;leukemia;leukemia treatment;Leukocyte Trafficking;Leukocytes;Libraries;Life Expectancy;limb ischemia;Malignant Neoplasms;Mass Spectrum Analysis;Measures;member;Metabolic Diseases;Methods;Modeling;Molecular Target;molecular targeted therapies;mortality;Mus;Myocardial Infarction;new therapeutic target;novel;novel anticancer drug;novel strategies;novel therapeutics;Patients;Peripheral;Persons;Pharmaceutical Preparations;Phenotype;phosphoproteomics;Phosphorylation;Physiological;Platelet aggregation;Pre-Clinical Model;Predisposing Factor;prevent;proteomic signature;Proteomics;Proto-Oncogene Proteins c-abl;Publishing;Resistance;response;Risk;Risk Factors;Rupture;Safety;side effect;Signaling Protein;Stroke;Survivors;targeted cancer therapy;Testing;Thrombosis;Toxic effect;Toxicity Tests;Translating;Tyrosine Kinase Inhibitor;Umbilical vein;Validation;Vascular Diseases;vascular inflammation;Vascular Permeabilities;vascular risk factor;wound healing

PROJECT_TITLE: Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies

STUDY_SECTION: VCMB

STUDY_SECTION_NAME: Vascular Cell and Molecular Biology Study Section[VCMB]


ADMINISTERING_IC: HD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Clinical Research;Contraception/Reproduction;Endometriosis;Estrogen;Genetics;Human Genome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Endometriosis is a clinically significant but poorly understood condition that affects the productivity and well- being of millions of women in their reproductive years. Our proposed research project will define a new Estrogen Receptor β-mediated gene network to understand the molecular mechanism of the inception and progression of endometriosis. This new conceptual advancement should provide new druggable targets to inhibit the survival and progression of endometriosis and reduce the side effects of current endometriosis treatments.

PI_NAMEs: HAN, SANG JUN  (contact)

PROGRAM_OFFICER_NAME: JOHNSTON, DANIEL STEPHEN

PROJECT_TERMS: Affect;angiogenesis;Apoptosis;Cell Death Induction;Cell Death Signaling Process;Cells;clinically significant;Complex;Conceptions;connective tissue growth factor;Cytoplasm;Data;Deposition;Disease;druggable target;EGF gene;Endometrial;endometriosis;Endometrium;Endothelial Cells;Epidermal Growth Factor Receptor;Epithelial Cells;Epithelium;Estrogen Receptor 2;Estrogen Receptors;Estrogens;Etiology;Gene Expression;gene network;Genes;genetic signature;Genomics;Growth;Growth Factor Gene;HIF1A gene;Human;Hypoxia Inducible Factor;hypoxia inducible factor 1;Immunologic Surveillance;Induction of Apoptosis;Infertility;Inflammasome;Inflammatory;Interferon alpha;Knowledge;Lesion;Mediating;Mesenchymal;Molecular;molecular targeted therapies;mouse model;Names;new therapeutic target;NFAT5 protein;novel;Nuclear;overexpression;Pathogenesis;Pathology;Pelvic Pain;Personal Satisfaction;Play;prevent;Productivity;Proteins;Receptor Signaling;reproductive;Research Project Grants;response;Retrograde Menstruation;Role;side effect;Signal Transduction;Site;Stimulation of Cell Proliferation;System;Tissues;transcriptome;Woman

PROJECT_TITLE: The Genomic Function of Estrogen Receptor Beta in Endometriosis

STUDY_SECTION: ICER

STUDY_SECTION_NAME: Integrative and Clinical Endocrinology and Reproduction Study Section[ICER]


ADMINISTERING_IC: HG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Project Narrative: Regions in the genome that are intolerant to new variation indicate potential functional importance and provide insights into genetic variation and disease. Despite the fact that clinical exome sequencing is increasingly used for diagnostic evaluation of patients with suspected Mendelian disorders and that rare variation has been shown to confer substantial disease risk in complex traits as well, a large percentage of Mendelian disorders remains unresolved and diagnostic rates of exome sequencing remains low. With the proposal of new statistical methods and user-friendly software implementations, this K01 aims to better account for ancestry and tissue-specific transcriptional intolerance to genetic variation in order to improve association mapping between genetic variation and disease and to ultimately advance precision medicine diagnostics and variant interpretation.

PI_NAMEs: HAYECK, TRISTAN JONATHAN (contact)

PROGRAM_OFFICER_NAME: LI, RONGLING

PROJECT_TERMS: Accounting;Address;Advisory Committees;Algorithms;analytical tool;Bayesian Modeling;Biological;burden of illness;cell type;Cells;Child;Clinical;clinical diagnostics;Clinical Management;Clinical Treatment;Collaborations;Communities;Complex;Computer software;Conserved Sequence;Data;Data Set;developmental disease;Diagnosis;Diagnostic;differential expression;Disease;disease heterogeneity;disease phenotype;disease-causing mutation;disorder risk;Environmental Exposure;European;Evaluation;exome;exome sequencing;Exons;Foundations;General Population;Genes;Genetic;Genetic Diseases;Genetic Models;Genetic study;Genetic Transcription;Genetic Variation;Genome;genome resource;Genotype-Tissue Expression Project;Goals;Grouping;Heterogeneity;Human;Immunology;improved;insight;interest;Investigation;Joints;Maps;Medical Genetics;Mendelian disorder;Mentors;Mentorship;Methodology;Methods;Modeling;multidisciplinary;Neurodevelopmental Disorder;novel;Parameter Estimation;Pathogenicity;Pathologist;Patients;Pattern;Pediatric Hospitals;Phenotype;Philadelphia;Population;population based;Population Heterogeneity;precision medicine;pressure;Prevalence;Proliferating;Protein Isoforms;Research;Resources;RNA Sequences;Running;Sample Size;Sampling;scale up;Scientist;Signal Transduction;software development;Statistical Methods;Structure;Techniques;Technology;Testing;Therapeutic;Time;Tissues;Training;trait;Trans-Omics for Precision Medicine;Transcript;transcriptomics;user friendly software;Variant;whole genome;Work

PROJECT_TITLE: Bayesian Hierarchical Methods for Localized Analysis of Genic Intolerance to Variation

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: SYRACUSE

ORG_NAME: UPSTATE MEDICAL UNIVERSITY

ORG_STATE: NY

PHR: Chronic kidney disease is a major public health concern, affecting over 37 million people in the US. In this project, we will study how mutations in myosin, a molecular motor protein, affect the ability of the kidneys to selectively filter out waste products. We will aim to identify approaches for activating myosin that can be used to preserve renal function or treat kidney disease.

PI_NAMEs: KRENDEL, MIRA  (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: Actins;Adhesions;Affect;Amino Acids;Animal Model;ATP Hydrolysis;Award;Binding;Biochemical;Biology;Cell Adhesion;Cell membrane;Cells;Chronic Kidney Failure;cohort;Cytoskeletal Modeling;Cytoskeletal Proteins;Cytoskeleton;Defect;Dialysis procedure;Dimensions;Disease;End stage renal failure;Endocytosis;Epithelial Cells;Etiology;Filtration;fluid flow;Focal and Segmental Glomerulosclerosis;Functional disorder;Genes;Genomics;glomerular basement membrane;glomerular filtration;glomerulosclerosis;Histologic;In Vitro;in vitro activity;in vivo;Inherited;Injury;insight;Kidney;Kidney Diseases;Kidney Transplantation;Knockout Mice;Lipids;Measures;mechanical properties;Mechanics;Methods;Microfilaments;migration;Missense Mutation;Molecular Motors;Motor;Motor Activity;mouse model;Movement;Mutation;Myosin ATPase;Nephrotic Syndrome;novel;Pathogenesis;Pathway interactions;Patients;Peptides;Persons;Phosphatidylinositols;podocyte;preservation;Process;protective effect;Proteins;Proteinuria;Public Health;Regulation;Renal function;Renal glomerular disease;Renal Replacement Therapy;restoration;Role;Shapes;Steroid-resistant idiopathic nephrotic syndrome;Tail;Testing;Therapeutic;Variant;Waste Products;Work

PROJECT_TITLE: Role of myosin 1e in podocyte biology and renal filtration

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Atherosclerosis;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: WINSTON-SALEM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Potentially inappropriate medications (PIMs) among older adults (age ≥65 years) result in preventable adverse health events. This proposal seeks to describe the epidemiology of PIM use in multiple multi-ethnic study populations, factors associated with PIM use, and assess whether PIM use is associated with incident mild cognitive impairment or dementia and brain pathology. Successful completion of this proposed research will identify a potential modifiable exposure antecedent to Alzheimer’s disease and other related dementias (AD/RD). We believe that the identification of such an exposure will support interventions to reduce PIM use and prevent AD/RD.

PI_NAMEs: BANCKS, MICHAEL PATRICK (contact)

PROGRAM_OFFICER_NAME: KWOK, RICHARD K

PROJECT_TERMS: Acetylcholine;Address;adjudication;Adult;Adverse event;aging related;Alzheimer's Disease;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Anti-Cholinergics;Atherosclerosis;Atherosclerosis Risk in Communities;Behavioral;Benzodiazepines;Black race;Brain imaging;Brain Pathology;Central Nervous System;Classification;Clinical;Clinical Data;Clinical Research;Clinical Trials;Cognitive;cognitive testing;cohort;Collection;Communities;comorbidity;Data;Dementia;dementia risk;design;Development;Diabetes Mellitus;Dose;epidemiologic data;Epidemiology;epidemiology study;Event;experience;follow-up;Future;Geography;Geriatrics;Goals;Health;Health Benefit;Health Care Costs;Health Status;Heart failure;Hispanic;Hospitalization;hospitalization rates;human old age (65+);Impaired cognition;Incidence;Individual;innovation;insight;Intervention;lifestyle intervention;Link;mild cognitive impairment;Morbidity - disease rate;mortality;multi-ethnic;Multi-Ethnic Study of Atherosclerosis;Natural History;Neurotransmitters;Non-Insulin-Dependent Diabetes Mellitus;obese person;older adult;Outcome;Overweight;Participant;Pathology;Patients;Peripheral Nervous System;Pharmaceutical Preparations;phenotypic data;physical inactivity;Population Heterogeneity;Positioning Attribute;Prevalence;prevent;Public Health;racial diversity;Registries;Research;Research Personnel;Resources;response;Risk;skills;Societies;structural determinants;study population;Subgroup;Testing;Time;treatment strategy;United States;weight loss intervention;Woman;Work

PROJECT_TITLE: Epidemiology of potentially inappropriate medication use and risk for mild cognitive impairment and dementia among ARIC, Look AHEAD, and MESA

STUDY_SECTION: NAME

STUDY_SECTION_NAME: Neurological, Aging and Musculoskeletal Epidemiology Study Section[NAME]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Drug Abuse (NIDA only);Health Services;Mental Health;Mental Illness;Prevention;Schizophrenia;Serious Mental Illness;Substance Misuse;Tobacco;Tobacco Smoke and Health

ORG_CITY: DURHAM

ORG_DEPT: PSYCHIATRY

ORG_NAME: DUKE UNIVERSITY

PHR: PROJECT NARRATIVE Smoking tobacco shortens the lifespan of adults with serious mental illness by 25 years and contributes to $317 billion in healthcare expenditures and indirect loss of earnings and disability benefits. In prior work, we developed a new model to deliver wider-reaching smoking cessation interventions to individuals with serious mental illness. This project proposes to test the efficacy of this new model in a multi-site randomized controlled trial.

PI_NAMEs: VILARDAGA, ROGER  (contact)

PROGRAM_OFFICER_NAME: AKLIN, WILL

PROJECT_TERMS: Abstinence;Address;Adult;American;Android;arm;Behavior Therapy;Behavioral;Behavioral Sciences;Biochemical;Cardiovascular Diseases;Cause of Death;Cellular Phone;Chronic Disease;cigarette smoke;clinical practice;Clinical Practice Guideline;comorbidity;comparative efficacy;Comprehension;Cost Analysis;cost comparison;cost effective;cost effectiveness;Cost Effectiveness Analysis;cost-effectiveness evaluation;craving;DA10;Data;Depressive disorder;design;Development;disability;Education;efficacy evaluation;efficacy testing;Elements;Ensure;evidence base;experience;feasibility research;follow-up;Future;General Population;handheld mobile device;health economics;Health Expenditures;Health Policy;high risk population;improved;Individual;innovative technologies;Intervention;Learning;Life Expectancy;life span;Measurement;Measures;Mediating;Mediation;Mediator;Mental Health;Metabolic Diseases;Methodology;Methods;mHealth;mobile application;mobile computing;Modeling;National Institute of Drug Abuse;Nicotine Dependence;nicotine replacement;nicotine use;novel;Outcome;Participant;Patients;Pennsylvania;Persons;pharmacologic;pilot trial;Population;population health;Prevalence;primary outcome;prolonged abstinence;Public Health;Quality-Adjusted Life Years;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Recurrence;Relapse;Research;Respiration Disorders;retention rate;Sampling;Schizophrenia;schizophrenia spectrum disorder;secondary outcome;severe mental illness;Site;Smoker;Smoking;smoking cessation;Smoking Cessation Intervention;Structure;substance use treatment;Symptoms;Technology;Testing;theories;therapy adherence;Time;Tobacco;Tobacco use;Training;treatment and outcome;Treatment Efficacy;Treatment outcome;United States Dept. of Health and Human Services;United States National Institutes of Health;Universities;usability;Work

PROJECT_TITLE: Randomized Controlled Trial of a Novel Smoking Cessation Application Tailored to Individuals with Serious Mental Illness

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Estrogen;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Non-Human;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: CORAL GABLES

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Our research will elucidate the mechanisms underpinning two long-standing questions: 1) how RING1B licenses transcriptional activation and chromatin architecture, and 2) its role in advanced metastatic breast cancer.

PI_NAMEs: MOREY, LLUIS  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: 3-Dimensional;Acute;Address;Architecture;Binding;Biological Assay;Biological Process;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Model;BT 474;cancer cell;Cells;Chemicals;ChIP-seq;Chromatin;Chromatin Structure;Clustered Regularly Interspaced Short Palindromic Repeats;cofactor;cohesin;Complex;Coupled;Data;Development;Distal;DNA;Endocrine;Enhancers;Epigenetic Process;ESR1 gene;Estrogen receptor positive;Estrogens;experimental study;Feedback;Fulvestrant;Gene Activation;Gene Chips;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene repression;Genes;Genetic Transcription;genome-wide;genome-wide analysis;GREB1 gene;Growth;Hi-C;Hormonal;hormone therapy;Hormones;human disease;Hybrids;in vivo;Licensing;Malignant Breast Neoplasm;Malignant Neoplasms;MCF7 cell;Mediating;Metabolism;Metastatic breast cancer;Multiprotein Complexes;mutant;Mutation;NCOA2 gene;NCOA3 gene;Neoplasm Metastasis;novel;Oncogenes;Oncogenic;overexpression;paralogous gene;patient derived xenograft model;Phenotype;Polycomb;PRC1 Protein;Precision Run-On Sequencing;Process;Proliferating;promoter;protein complex;Proteins;Proteomics;recruit;Regulator Genes;Regulatory Element;Reproduction;Research;Resistance;Resolution;response;RNA;Role;stem cell fate;stem cells;steroid hormone;Steroid Receptors;T47D;Tamoxifen;Testing;Transcriptional Activation;transcriptome sequencing;tumor;tumorigenesis;Work;Xenograft Model

PROJECT_TITLE: Mechanisms of RING1B and PRC1 complexes in transcriptional activation

STUDY_SECTION: CSME

STUDY_SECTION_NAME: Cell Signaling and Molecular Endocrinology Study Section[CSME]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Building Research Capacity at Institutions with Limited NIH Funding;Neurosciences

ORG_CITY: JAMAICA

ORG_DEPT: BIOLOGY

ORG_NAME: YORK COLLEGE

PHR: Project Narrative: Relevance to the mission of NIH The relevance of the current proposal to public health is based on extending and refining the knowledge of how the mammalian cortex works: understanding how specialized circuits in the brain are constructed and wired together provides the basis for understanding cortical function in general. Understanding the basic cortical organization of the normal brain is essential, as it provides the standard against which it can be judged which processes can be seen to be altered or damaged and subsequently treated in disorders that affect the cerebral cortex as in schizophrenia and dyslexia or sensory disorders such as central auditory processing disorders, amblyopia and neurodevelopmental disorders that impact somatosensory processing.

PI_NAMEs: GARCIA-MARIN, VIRGINIA  (contact)

PROGRAM_OFFICER_NAME: OSBORNE, LESLIE CAROL

PROJECT_TERMS: 3-Dimensional;Acceleration;Affect;Amblyopia;Area;Automobile Driving;Brain;Brain region;Cell Density;cell type;Cells;Central Auditory Processing Disorder;Cerebral cortex;Characteristics;Communities;Confocal Microscopy;connectome;connectome data;Data;density;design;Development;Disease;Dyslexia;Electron Microscopy;excitatory neuron;Goals;imaging Segmentation;Individual;inhibitory neuron;inter-individual variation;Ions;Knowledge;Label;large scale data;Link;Macaca;Measures;Methods;Mission;Modeling;Monkeys;Morphology;Neurodevelopmental Disorder;Neurons;nonhuman primate;Outcome;Performance;Population;population based;Predisposition;Presynaptic Terminals;Process;Property;Public Health;Publications;reconstruction;Reporting;Research;Research Support;Resolution;Role;Scanning Electron Microscopy;Schizophrenia;Scholarship;Sensory;sensory cortex;Sensory Disorders;somatosensory;species difference;Structure;Surface;Synapses;System;Technology;Testing;Thalamic structure;Thinking;United States National Institutes of Health;Work

PROJECT_TITLE: Understanding the Microcircuits in Monkey Sensory Cortices: a Connectomic Approach


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Homelessness;Sleep Research;Social Determinants of Health

ORG_CITY: SAN FRANCISCO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE This proposal will have public health importance because (1) it will increase mentoring of junior scientists interested in conducting patient-oriented research to improve care for vulnerable aging populations, and (2) it will inform interventions to improve sleep management in older homeless adults, in order to improve their quality of life and decrease worsening of geriatric conditions.

PI_NAMEs: KUSHEL, MARGOT B (contact)

PROGRAM_OFFICER_NAME: BAKOS, ALEXIS DIANE

PROJECT_TERMS: 20 year old;Acute;Adult;Advance Care Planning;Affect;aged;Aging;aging process;Award;Behavior;Behavioral;California;career;career development;Caring;clinical practice;Clinical Sciences;cohort;Cohort Studies;Communities;Coupled;Crowding;Data;Data Collection;design;Educational Status;Elderly;Emergency Situation;Enrollment;Environment;environmental change;Environmental Risk Factor;experience;Faculty;Family Relationship;Fellowship;Funding;General Population;Goals;Health;health service use;Health Services;Health Status;Health system;Healthcare;High Prevalence;Homeless persons;Homelessness;Housing;Impaired cognition;improved;improvement on sleep;indexing;Individual;Infrastructure;insight;Institution;interest;Internist;Intervention;Interview;Learning;Link;Living Arrangement;Longitudinal cohort study;Medicine;Mental Depression;Mentors;Mid-Career Clinical Scientist Award (K24);Morbidity - disease rate;mortality;older adult;Older Population;Outcome;Paper;Participant;patient oriented research;Phase;Physical environment;Policies;poor sleep;Population;Poverty;Premature aging syndrome;Prevalence;Primary Care;professor;programs;prototype;Provider;Public Health;Publishing;Qualitative Methods;Quality of life;Recommendation;Reporting;Research;research and development;Research Personnel;Research Support;Resources;San Francisco;Scholars Program;Science;Scientist;service providers;Services;Shelter facility;Sleep;Sleep Disorders;sleep quality;social;Social Environment;social factors;social health determinants;Social support;Source;Structure;substance use;supported housing;System;Time;Training;Translational Research;United States National Institutes of Health;Universities;Vulnerable Populations

PROJECT_TITLE: Mentoring Researchers in Aging in Vulnerable Populations

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE (3 SENTENCES) We are in dire need to determine if higher protein intake, above the current recommendation (0.8/kg/d), can produce long-lasting beneficial effects to prevent age-related loss of muscle mass and function in older adults. This proposal determines the long-term effects of higher protein intake on prevention of age-related mobility disability; and identifies if dietary proteins enhance mobility function by improving the gut bacterial composition and reducing inflammation in the body. Findings from this K01 can drive age-specific dietary recommendations, replacing the current one-size-fits-all approach, to enhance mobility function in older adults by improving gut health and inflammation; and the acquired skills will help the Principal Investigator to integrate omics (gut microbiome) and non-omics (dietary intake) data towards a long-term career goal to develop “Precision Nutrition” strategies and age-specific dietary advice to promote healthy aging.

PI_NAMEs: FARSIJANI, SAMANEH  (contact)

PROGRAM_OFFICER_NAME: SERRA, MONICA CHRISTINE

PROJECT_TERMS: 16S ribosomal RNA sequencing;absorption;Address;Adopted;age related;age-related muscle loss;Aging;Biology;Biometry;Body Composition;Body mass index;Body Weight;C-reactive protein;career;career development;Chronic;Clinical Research;cohort;Communities;Compensation;Data;Diet;dietary;dietary guidelines;Dietary intake;Dietary Proteins;dysbiosis;Eligibility Determination;Epidemiology;Food;frailty;Functional impairment;functional loss;Gait speed;Goals;gut dysbiosis;gut health;gut inflammation;gut microbiome;gut microbiota;Health;health data;Health Policy;healthy aging;Immunoassay;improved;improved mobility;Inflammaging;Inflammation;Inflammatory;inflammatory marker;insight;Interdisciplinary Study;Interleukin-6;Knowledge;Link;Long-Term Effects;Mass Spectrum Analysis;Measures;Mediating;Mediation;Mediator;men;microbial;microbial composition;microbiome composition;Mobility decline;Mobility disability;Muscle;muscle form;Muscle function;Muscle Proteins;nutrition;nutritional epidemiology;Nutritional Study;Observational Study;older adult;Older Population;Outcome;Outcome Study;Participant;Patient Self-Report;Pattern;Physical Function;Plants;Plasma;Play;Pragmatic clinical trial;precision nutrition;prevent;Prevention;Principal Investigator;Production;Protein Biosynthesis;protein distribution;protein intake;protein metabolism;Proteins;Public Health;Randomized;Recommendation;Recommended Dietary Allowance;Regression Analysis;Research;Resistance;response;Risk;Risk Reduction;Role;Sampling;Serum;Shapes;skill acquisition;skills;Source;Statistical Models;Training;Walking;walking speed;Woman

PROJECT_TITLE: The relationship between protein intake, gut microbiome, inflammaging and loss of mobility in older adults

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Radiation Oncology

ORG_CITY: STANFORD

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Development of AI-Augmented quality assurance tools for radiation therapy Project narrative This project is aimed at developing practical deep learning solutions for accurate and reliable treatment plan verification. If successful, the research will substantially improve the safety, quality and efficiency of radiation oncology practice, and enable patients to truly benefit from modern radiation therapy.

PI_NAMEs: XING, LEI  (contact)

PROGRAM_OFFICER_NAME: OBCEMEA, CEFERINO H

PROJECT_TERMS: 3-Dimensional;Accountability;Architecture;Archives;Artificial Intelligence enhanced;Back;Brachytherapy;Clinical;clinical translation;Collimator;Communities;Consumption;cost;Data;deep learning;deep learning model;Dependence;design;Development;Dose;Evaluation;Geometry;High-Dose Rate Brachytherapy;Image;improved;indexing;Intensity-Modulated Radiotherapy;Learning;Machine Learning;Maps;Measurement;Methods;Modality;Modeling;Modernization;Monitor;novel;Output;Patient Care;Patient Education;Patients;Performance;Plant Leaves;Positioning Attribute;proton therapy;quality assurance;Radiation Oncology;Radiation therapy;Records;Research;Residual state;Safety;Scheme;Shapes;success;System;Techniques;Testing;Time;tool;Training;treatment planning;treatment strategy;Uncertainty;Validation;X-Ray Computed Tomography


NIH_SPENDING_CATS: Clinical Research;Lung;Lymphatic Research;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: DENVER

ORG_NAME: NATIONAL JEWISH HEALTH

ORG_STATE: CO

PHR: PROJECT NARRATIVE Cigarette smoking-related lung diseases like chronic obstructive pulmonary disease (COPD) remain a leading cause of death worldwide. We believe Lyve-1 positive peribronchial interstitial macrophages play a key role in promoting the pathologic thickening of the small airway walls in response to cigarette smoke and may be a potential therapeutic target to intervene in COPD pathogenesis. We will test the hypothesis that matrix metalloprotein 9 production in response to Lyve-1 on the IM surface binding to hyaluronic acid promotes airway wall remodeling and fibrosis after prolonged cigarette smoke exposure.

PI_NAMEs: HUME, PATRICK SCOTT (contact)

PROGRAM_OFFICER_NAME: POSTOW, LISA

PROJECT_TERMS: Address;Airway Disease;airway obstruction;airway remodeling;Alveolar Macrophages;Animal Model;Aorta;asthma model;Award;Basic Science;Binding;Biology;Blood Circulation;Board Certification;career;career development;Cause of Death;CD44 gene;Cells;Cellular biology;Chronic;Chronic Obstructive Pulmonary Disease;Cicatrix;Cigarette;cigarette smoke;cigarette smoke-induced;Cigarette Smoker;cigarette smoking;Collagen;Critical Care;Data;Data Analyses;Deposition;design;Development;Development Plans;Doctor of Philosophy;Dropout;Embryo;Endothelium;Environment;experience;exposure to cigarette smoke;Extracellular Matrix;Fellowship;Fibroblasts;Fibrosis;Flow Cytometry;follower of religion Jewish;Gelatin;Gelatinase B;Goals;Health;Human;Hyaluronic Acid;Hyaluronic Acid Binding;Immunofluorescence Immunologic;In Situ;in vitro Model;Individual;Infiltration;Inflammation;Inflammatory;Injury;innovation;Institution;International;interstitial;Laboratories;Lead;Leadership;Ligation;Link;Location;Lung;Lymphatic function;lymphatic vessel;Macrophage;Matrix Metalloproteinases;Mediating;Medical Residency;Medicine;Mentors;Mentorship;Metalloproteases;Metalloproteins;MMP9 gene;Molecular Weight;monocyte;morphometry;mouse model;Mus;Myofibroblast;National Heart, Lung, and Blood Institute;novel therapeutics;Pathogenesis;Pathologic;Pathology;Physicians;Play;Population;Production;Public Health;Publications;receptor;recruit;repaired;Research;Research Personnel;Research Project Grants;Research Training;response;Role;Scientist;Signal Transduction;small airways disease;Smoke;Smoker;smoking-related lung disease;Structure of parenchyma of lung;Surface;Terminal Bronchiole;Testing;therapeutic target;Tissues;Training;Training Programs;transcriptome sequencing;Transgenic Animals;Transgenic Mice;translational physician;undergraduate student;uptake;Work;Writing

PROJECT_TITLE: Interstitial macrophages in cigarette smoke-induced small airway remodeling

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS(OA)]


ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: Project Narrative Recovery from acute kidney injury (AKI) is often incomplete and leaves behind a kidney that is prone to develop chronic kidney disease (CKD). The proposed research will explore how various functions of the kidney are regulated and evolve as the kidney recovers from AKI and how the evolution and ultimate outcome are affected by pre-existing CKD, standard medical treatments including angiotensin blockade, changes in dietary NaCl, and inhibitors of the principle kidney glucose transporter, SGLT2. Experiments will employ standard rat models of AKI where key variables can be measured that cannot be measured in human subjects.

PI_NAMEs: THOMSON, SCOTT CULVER (contact);VALLON, VOLKER

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Ablation;absorption;Acute;Acute Renal Failure with Renal Papillary Necrosis;Affect;Amino Acids;Angiotensins;Animals;Area;base;Behavior;Blood Pressure;Chronic Kidney Failure;Clinical;Clinical Trials;Compensation;Coupling;Creatinine clearance measurement;Data;design;Diagnosis;Diet;dietary;Disease;Electrolytes;Equilibrium;Event;Evolution;Excretory function;experimental study;Feedback;Future;Glomerular Capillary;Glucose Transporter;healing;hemodynamics;Heterogeneity;Homeostasis;Hospitals;Human;human model;human subject;Hypersensitivity;Hypoxia;Impairment;improved;Incidence;Individual;Infarction;Infusion procedures;inhibitor;injured;Injury;Injury to Kidney;Intervention;Ischemia;Kidney;Knowledge;Left;Liquid substance;Mathematics;Measures;Medical;Meta-Analysis;Metabolic stress;Metabolism;Methods;Micropuncture;Microscopic;Modeling;Nephrons;Outcome;Patients;Physiological;Physiology;Predisposition;preservation;pressure;prevent;Randomized;Rattus;Recovery;Regulation;Renal Blood Flow;Renal function;Renal Mass;Renin-Angiotensin System;Reperfusion Therapy;Research;Research Personnel;response;Saline;Sodium-Restricted Diet;Stress Tests;Techniques;Testing;Time;Tubular formation;Urine

PROJECT_TITLE: Glomerular and Tubular Function in the Recovering Kidney

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


NIH_SPENDING_CATS: Genetics;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: DALLAS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Cell competition, the process of eliminating viable but “less fit” neighbor cells, has been proposed as a surveillance mechanism to ensure normal development and also has been suggested to act as a barrier to interspecies chimerism. We uncovered a previously unknown mode of cell competition between pluripotent stem cells from different species. This project aims to decipher the underlying molecular mechanisms and develop effective strategy to enable interspecies organogenesis by suppressing interspecies cell competition.

PI_NAMEs: WU, JUN  (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Animals;Apoptosis;Attention;Automobile Driving;blastocyst;Cell Death;Cell Survival;Cells;Chemicals;Chimera organism;Chimerism;Coculture Techniques;comparative;Competence;Complement;Complex;Data;Development;disabled;Distant;Embryo;embryo culture;Embryonic Heart;Endogenous Retroviruses;Endothelium;Engraftment;Ensure;fetal;fitness;Generations;Genes;Genetic;Growth;Homeostasis;Human;human pluripotent stem cell;hypoxia inducible factor 1;implantation;improved;In Vitro;in vitro Model;in vivo;Innate Immune Response;Inner Cell Mass;innovation;Kidney;Knockout Mice;Macaca mulatta;Medical;Molecular;Mus;Nature;Organ;Organ Donor;Organ Transplantation;Organogenesis;p53 Signaling Pathway;p65;Pancreas;Play;pluripotency;Pluripotent Stem Cells;Process;Rattus;RELA gene;Research;Research Personnel;Rhesus;Role;Shapes;Signal Transduction;single-cell RNA sequencing;Source;stem cell survival;success;System;Thymus Gland;Tissues;TP53 gene;transcriptome;transcriptome sequencing;Transmission Electron Microscopy;Work

PROJECT_TITLE: Dissect the mechanisms underlying interspecies pluripotent stem cell competition

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Genetics;Human Genome;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE An unmet clinical need exists for new therapeutic concepts in lung adenocarcinoma (LUAD), the most common subtype of lung cancer. We hypothesize that progression, phenotypic heterogeneity, proliferative potential and treatment resistance in LUAD arise from a subset of cancer cells that acquire a high-plasticity cell state (HPCS). In this study we interrogate the function and molecular drivers of the HPCS in LUAD tumors, which may inform future therapeutic strategies.

PI_NAMEs: TAMMELA, TUOMAS  (contact)

PROGRAM_OFFICER_NAME: AULT, GRACE S

PROJECT_TERMS: Ablation;Address;Adenocarcinoma Cell;Biological Assay;bioluminescence imaging;cancer cell;candidate identification;cDNA Expression;Cells;Cessation of life;Chemoresistance;chemotherapy;Chromatin;Clinical;CRISPR/Cas technology;Data;Differentiation and Growth;Disease;Dose;Endowment;Evolution;experimental study;Future;gain of function;Gene Expression;Gene Expression Profile;Genetic;Genetic Transcription;Genetically Engineered Mouse;Genotype;Growth;Heterogeneity;Human;In Situ;in vivo;Investigation;Knowledge;Lesion;loss of function;Lung Adenocarcinoma;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Measurement;Methods;Modeling;Molecular;Molecular Target;Mus;Neoplasms;Non-Small-Cell Lung Carcinoma;novel;novel therapeutics;overexpression;patient derived xenograft model;Patient-Focused Outcomes;Patients;Phenotype;premalignant;pressure;programs;Proliferating;prospective;Reporter;Resolution;response;Role;single cell mRNA sequencing;single-cell RNA sequencing;small hairpin RNA;Solid Neoplasm;System;Testing;Therapeutic;therapeutically effective;therapy resistant;transcription factor;transcriptome sequencing;Transplantation;Treatment Failure;tumor;tumor progression;Tumor stage;Work

PROJECT_TITLE: Targeting plasticity in lung cancer

STUDY_SECTION: CAMP

STUDY_SECTION_NAME: Cancer Molecular Pathobiology Study Section[CAMP]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Gene Therapy;Genetics;Immunotherapy;Precision Medicine

ORG_CITY: Boston

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: TUFTS UNIVERSITY MEDFORD

PHR: We propose the development of a new non-invasive method that may be used to optimize and monitor treatment responses in patients that are receiving CAR-T cell therapy. The approach is relatively simple and the instrumentation amenable to miniaturization. Thus, if successful, it should be possible to translate the technology to the clinic or as point of care device for monitoring human patients with the frequency that is needed to optimize therapeutic outcomes.

PI_NAMEs: GEORGAKOUDI, IRENE  (contact)

PROGRAM_OFFICER_NAME: MCKEE, TAWNYA C

PROJECT_TERMS: Antibodies;B lymphoid malignancy;B-Cell Development;B-Lymphocytes;Biological Markers;Blood Circulation;Blood flow;Blood specimen;Blood Vessels;blood-based biomarker;CAR T cell therapy;Cell Communication;Cells;cellular engineering;Characteristics;chimeric antigen receptor;chimeric antigen receptor T cells;Circulation;Clinic;Clinical Trials;Complex;Computer software;Data;Data Science;Data Set;Detection;Development;Devices;Diagnostic;Disease remission;Dose;Ear;early onset;Engineering;expectation;Flow Cytometry;Fluorescence;Frequencies;Goals;Hematologic Neoplasms;Hematology;Human;improved;In Vitro;in vivo;individual patient;individual response;Infusion procedures;innovation;insight;instrumentation;Intervention;Label;Leukemic Cell;Leukocytes;light scattering;Machine Learning;Measurement;Methods;Microfluidic Microchips;Microfluidics;Miniaturization;Monitor;monitoring device;multidisciplinary;Mus;non-invasive monitor;novel;novel marker;Oncology;Optics;Outcome;Patient Monitoring;patient response;patient safety;Patients;personalized approach;point of care;precision medicine;Precursor B-Lymphoblast;predicting response;Proteins;Protocols documentation;Refractory;Relapse;Resolution;response;Sensitivity and Specificity;signal processing;Signal Transduction;Signaling Protein;Solid Neoplasm;Source;standard care;Survival Rate;System;T-Cell Receptor Therapy;T-Lymphocyte;targeted treatment;TCR Activation;Technology;Temperature;Testing;therapy outcome;Time;tool;Toxic effect;Translating;translational potential;treatment optimization;Treatment Protocols;treatment response;Treatment-related toxicity;tumor;Tumor Burden;Validation;Variant;Whole Blood

PROJECT_TITLE: Development of a novel platform for label-free monitoring of CAR-T cell interactions in vivo

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Breast Cancer;Cancer;Chronic Pain;Natural Products;Neurodegenerative;Neurosciences;Pain Research;Peripheral Neuropathy;Prevention;Women's Health Research

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Up to 70% of the 650,000 of cancer patients treated with chemotherapy will develop chemotherapy induced peripheral neuropathy (CIPN) that results in poor compliance, decreased quality of life, higher recurrence rates, and increased healthcare costs. Despite advances in therapeutic agents, paclitaxel remains one of the primary treatments of choice in hormone resistant breast cancer yet it continues to induce one of the highest incidences of CIPN. As there are currently no effective treatments for CIPN, the over-arching hypothesis of this proposal is that we have discovered that an existing drug used in treatment of other conditions, can be used to decrease or prevent CIPN caused by treatment with paclitaxel.

PI_NAMEs: LECKENBY, JONATHAN IAN;NOBLE, MARK D (contact)

PROGRAM_OFFICER_NAME: ALTSHULER, RACHEL DINA

PROJECT_TERMS: 4-Aminopyridine;Acute;Address;Aftercare;allodynia;Animals;Axon;Brain;Breast Cancer Cell;Breast Cancer Model;Burning Pain;cancer cell;Cancer Patient;cancer survival;Cell Physiology;Centers for Disease Control and Prevention (U.S.);chemotherapy;Chemotherapy-induced peripheral neuropathy;Chronic;Clinical Research;clinical translation;clinically relevant;Development;dosage;Drug usage;effective therapy;Effectiveness;Electrophysiology (science);Elements;EO771;experimental study;Exposure to;Fatty acid glycerol esters;foot;functional outcomes;Gait;Hand;healing;Health Care Costs;Histologic;Histology;Hormones;Incidence;Individual;inhibitor;innovation;Kidney;Malignant Breast Neoplasm;Malignant Neoplasms;mammary;Measures;Medical;Mitochondria;Motor;mouse model;Mus;muscle physiology;Muscle Weakness;Muscular Atrophy;Myelin;myelination;Nerve;Nerve Regeneration;Neurologic;Neurons;non-compliance;novel;novel strategies;Numbness;Outcome;Paclitaxel;painful neuropathy;Pathologic;Patients;Peripheral nerve injury;Peripheral Nerves;Peripheral Nervous System Diseases;Pharmaceutical Preparations;Pilot Projects;Potassium Channel;preservation;pressure;prevent;Prevention;Quality of life;Recovery of Function;Recurrence;regenerative agent;Regimen;Relapse;repaired;Research;Resistance;response;Skeletal Muscle;Skin;skin wound;Spinal cord injury;Structure;Survival Rate;Symptoms;Syndrome;Testing;Therapeutic;Therapeutic Agents;Translations;Traumatic injury;treatment choice;Treatment Cost;tumor;tumor growth;United States

PROJECT_TITLE: Prevention and treatment of paclitaxel-induced peripheral neuropathy


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Infectious Diseases;Urologic Diseases

ORG_CITY: Chicago

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: NARRATIVE We discovered the ability of urinary tract pathogen Proteus mirabilis to rapidly kill competitors like Escherichia coli in a previously unknown contact-dependent manner. We propose to identify the killing system and its regulation, define the mechanism of action, and elucidate its role for competition with E. coli during polymicrobial infections of the urinary tract in vivo. Results of this proposal will add an additional mechanism of how P. mirabilis is able to establish dominance in the urinary tract.

PI_NAMEs: BEHNSEN, JUDITH  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Affect;Anabolism;antimicrobial;Biochemical;Biological Assay;Bioluminescence;catheter associated UTI;Catheterization;Catheters;Cells;cellular targeting;Citrobacter rodentium;Clinical;Coculture Techniques;Code;Cysteine;Cytolysis;Death Rate;Development;DNA;DNA Damage;Enterobacteriaceae;Environment;Equilibrium;Escherichia coli;experimental study;Factor V;Fluorescence Microscopy;Gel;Genes;genetic approach;Genome;Goals;healthcare-associated infections;Human;in vivo;Infection;Klebsiella pneumoniae;Libraries;Mediating;Microbial Biofilms;Molecular;mouse model;mutant;novel;Organ;Oxidation-Reduction;pathogen;Patients;Penetration;Peripheral;Phase;Proteus mirabilis;quorum sensing;Reducing Agents;Regulation;Regulatory Pathway;response;Risk;Role;Sepharose;Sepsis;Shapes;Signaling Molecule;Silicones;Solid;Surface;System;Testing;transcriptome sequencing;urinary;Urinary tract;Urinary tract infection;Urine

PROJECT_TITLE: Investigating a novel contact-dependent killing system and its contribution to pathogen dominance in the urinary tract


NIH_SPENDING_CATS: Kidney Disease;Regenerative Medicine

ORG_CITY: FARMINGTON

ORG_NAME: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT

ORG_STATE: CT

PHR: PROJECT NARRATIVE The kidney local microenvironment comprises diverse cell types, factors, and structural components—certain to be instrumental for kidney maintenance and repair—yet very little is known about how these components affect acute kidney injury (AKI). We have determined that a protein expressed soon after AKI organizes a favorable microenvironment to facilitate cell-matrix interactions and repair injured kidneys by recruiting a powerful growth factor. Deeply exploring these and other features of cell-matrix interactions in AKI will be greatly beneficial for constructing an AKI early warning system and designing novel therapeutic strategies to prevent or mitigate AKI.

PI_NAMEs: ZHOU, DONG  (contact)

PROJECT_TERMS: 3-Dimensional;Acute Renal Failure with Renal Papillary Necrosis;Affect;Attention;Binding;Biological;Cell Death;Cell Proliferation;cell type;Cells;Cessation of life;Chronic Kidney Failure;Complex;conditional knockout;Creatinine;Data;design;Deterioration;Development;Disease;Environment;Extracellular Matrix;Extracellular Matrix Proteins;Fibroblasts;Glycoproteins;Growth Factor;Hospitalization;In Vitro;in vivo;Incubated;Inflammatory;injured;injury and repair;Injury to Kidney;insight;interstitial;Investigation;Ischemia;Kidney;kidney cell;kidney repair;knock-down;Knockout Mice;long-term sequelae;Macrophage;Maintenance;Mediating;Modeling;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Output;overexpression;Pathogenesis;Peptides;prevent;Process;Proteins;Proteomics;recruit;Regimen;Renal function;renal ischemia;Renal tubule structure;repaired;Repression;Research;Risk;Role;scaffold;Serum;Shapes;SHH gene;Signal Transduction;Source;System;Techniques;Testing;Treatment Efficacy;Tubular formation;tumorigenesis;Urine

PROJECT_TITLE: Importance of cell-matrix interactions in kidney repair after acute kidney injury


NIH_SPENDING_CATS: Behavioral and Social Science;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Liver Disease;Organ Transplantation;Racial and Ethnic Minority Health Research;Social Determinants of Health;Transplantation

ORG_DEPT: SURGERY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE The benefits of kidney and liver transplantation should be available to all Americans, but geographic, racial/ethnic, gender, and other disparities, plus a shortage of transplantable organs, have frustrated that promise. The Organ Procurement and Transplantation Network has resolved to eliminate geographic boundaries to reduce geographic disparity through implementation of a continuous allocation score (CAS), but choosing weights indiscriminately in a CAS system could easily introduce unintended consequences. We propose to use iterated simulations to: 1) design CAS weights to increase transplant benefit without creating unintended new disparities; 2) modify the CAS to achieve the greatest possible equity in allocation; and 3) modify the CAS to decrease discard of transplantable organs.

PI_NAMEs: MASSIE, ALLAN B (contact)

PROGRAM_OFFICER_NAME: ABBOTT, KEVIN C

PROJECT_TERMS: Address;Affect;Age;Algorithms;American;Antibodies;behavior change;Biological;Black race;Blood;blood group;Cessation of life;Characteristics;Childhood;Clinical;Collaborations;combinatorial;Communities;Complex;Data;design;Dimensions;Disparity;dynamic system;Ensure;Equity;Ethics;ethnic disparity;Ethnic Origin;Evolution;flexibility;Frustration;Gender;geographic disparity;Geography;Goals;HLA Antigens;Hospitals;improved;Incidence;interest;Ischemia;Kidney;Kidney Transplantation;Life;Liver;liver transplantation;Logistics;Matched Group;mathematical methods;Methodology;Methods;mortality;mosaic;Natural experiment;Organ;organ allocation;organ procurement transplantation network;Organ Procurements;Organ Transplantation;Outcome;Participant;Policies;Policy Maker;Population;Race;racial difference;racial disparity;Rest;Rural;simulation;social health determinants;socioeconomic disparity;socioeconomics;Solid;Stigmatization;Subgroup;System;Testing;Time;tool;transplant centers;Transplantation;Wait Time;Waiting Lists;Weight

PROJECT_TITLE: Continuous allocation score design for guaranteeing equity and reducing discards in kidney and liver transplantation

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: LOS ANGELES

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE In the United States and especially in Southern California, new cases of HIV continue to accrue, especially among those who identify as having minority racial/ethnic and/or sexual/gender status. New approaches that integrate combination biomedical, behavioral, technological and structural interventions offer exciting possibilities to significantly reduce HIV transmission, especially in key populations of people living with HIV or at risk with co-occurring mental health and substance use disorders and/or barriers in access to social and structural determinants of health. The Center for HIV Identification, Prevention, and Treatment Services (CHIPTS) mobilizes world class leaders and affected communities in the areas of science, networking and capacity building to lead the HIV prevention agenda both in the U.S. and internationally, particularly in addressing these comorbidities among those living with or at risk for HIV.

PI_NAMEs: SHOPTAW, STEVEN J (contact)

PROGRAM_OFFICER_NAME: GORDON, CHRISTOPHER M

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Adherence;Affect;AIDS prevention;analytical method;Anti-Retroviral Agents;Area;Behavioral;behavioral and social science;Behavioral Sciences;California;Caring;Collaborations;Color;Communities;comorbidity;COVID-19;Criminal Justice;Development;Dimensions;diversity and equity;Ensure;Epidemic;Equity;Ethnic Origin;Event;experience;Fostering;Friends;Funding Mechanisms;Future;Gender;Goals;Grant;Health;Health system;HIV;HIV Infections;HIV/AIDS;implementation barriers;implementation science;improved;innovation;International;Intervention;Investments;Measurement;meetings;member;men who have sex with men;Mental Health;Mentors;Mentorship;Methods;Mission;multidisciplinary;National Institute of Mental Health;next generation;novel;novel strategies;Office of Administrative Management;Outcome;Peer Review;Persons;Policies;Policy Maker;Policy Making;Population;Populations at Risk;Prevention;Prevention program;Prevention Research;prevention service;Prevention strategy;Provider;Public Health;racial minority;Research;Research Design;Research Institute;Research Personnel;Risk;Role;Science;Scientist;Services;social determinants;Social Justice;Social Work;Statistical Methods;Strategic Planning;structural health determinants;Substance Use Disorder;success;symposium;System;Technology;Training;transgender;transgender women;transmission process;treatment services;United States;United States National Institutes of Health;Universities;uptake;Viral

PROJECT_TITLE: Center for HIV Identification, Prevention and Treatment Services


NIH_SPENDING_CATS: Biotechnology;Diabetes;Infectious Diseases;Regenerative Medicine;Wound Healing and Care

ORG_CITY: CHAPEL HILL

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE An ideal therapeutic for chronic wounds must address the impairment of the host immune response while also possessing antibacterial activity whereby due to the high prevalence of chronic wound-related amputations and mortality, the need for this dual-action therapeutic is urgent. We have recently begun to develope NO-releasing glycosaminoglycan biopolymers whose multi-faceted roles will allow for a wound healing therapeutic that: 1) eradicates common wound pathogens with minimal toxicity to cells and tissues; 2) modulates wound-related inflammation; and, 3) promotes re-epithelialization to facilitate wound closure. Here we will build upon our previous successes in developing NO-releasing therapeutics and understanding their benefits in wound healing to help populations afflicted by non-healing chronic wounds, including those with type 2 diabetes.

PI_NAMEs: SCHOENFISCH, MARK H (contact);WALLET, SHANNON MARGARET

PROGRAM_OFFICER_NAME: LI, YAN

PROJECT_TERMS: 3-Dimensional;Address;Adhesions;Affect;Amputation;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;Bacterial Antibiotic Resistance;Biological Assay;Biopolymers;Cell Culture Techniques;cell motility;Cell Proliferation;Cells;chronic wound;clinical translation;Complex;Dermal;Development;Diabetes Mellitus;Diabetic mouse;diabetic ulcer;Disease;Dose;efficacy evaluation;Failure;Frequencies;Future;Gases;Glycosaminoglycans;Goals;Hand;High Prevalence;Human;Immune;immune function;Immune response;immunoregulation;Impaired healing;Impairment;In Vitro;in vivo;Individual;Infection;Inflammation;Inflammatory;Knowledge;Macrophage;microbial;migration;Molecular Weight;Monitor;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;neutrophil;Nitric Oxide;Nitric Oxide Donors;Non-Insulin-Dependent Diabetes Mellitus;pathogen;Patients;Pattern;Phenotype;Physiology;Play;Population;Process;Production;programs;Property;Punch Biopsy;re-epithelialization;Research;Resistance;resistant strain;response to injury;Role;scaffold;Series;Signal Transduction;Signaling Molecule;Skin Tissue;Structure;success;Sulfate;System;Systems Biology;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;Tissue Model;tissue reconstruction;tissue repair;Tissues;Toxic effect;translational therapeutics;Treatment Efficacy;treatment response;two-dimensional;wound;wound closure;wound healing;Wound healing therapy;Wound Infection;wound treatment

PROJECT_TITLE: Nitric oxide-releasing glycosaminoglycans for treating complex wounds

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


NIH_SPENDING_CATS: Behavioral and Social Science;HIV/AIDS;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PROJECT_TERMS: Accountability;Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Collaborations;Communication;Communities;community advisory board;community partners;comorbidity;Consultations;Country;cultural competence;Data;Decision Making;Dedications;Doctor of Philosophy;Ensure;Epidemic;Evaluation;Faculty;Fostering;Goals;Health;HIV;improved;Incidence;Infrastructure;innovation;Institution;International;Leadership;Measures;meetings;member;Mental Health;Mentors;Mission;Monitor;multidisciplinary;National Institute of Mental Health;Persons;Population;Prevalence;Prevention program;prevention service;Prevention strategy;Procedures;Process;Productivity;Program Evaluation;programs;Research;Research Personnel;Resources;Risk;scale up;Science;Scientist;Services;social determinants;social media;Strategic Planning;structural health determinants;Substance Use Disorder;Sum;support network;synergism;therapy development;Training Activity;transmission process;treatment services;United States National Institutes of Health;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: MILBURN, NORWEETA GERMAINE (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;AIDS prevention;Award;Behavioral;care systems;career;Caring;Collaborations;Communities;comorbidity;COVID-19;cultural competence;data access;Data Set;design;Development;diversity and equity;Educational workshop;equity, diversity, and inclusion;Ethnic Origin;Event;experience;Faculty;Fellowship Program;Fostering;Funding;Funding Mechanisms;Gender;Grant;HIV;HIV Infections;implementation science;improved;Incidence;innovation;Institution;Interdisciplinary Study;interest;Investigation;Investments;Leadership;Link;Mental Health;Mentors;Mentorship;Mission;multidisciplinary;National Institute of Mental Health;next generation;novel;Peer Review;Persons;Policy Maker;Postdoctoral Fellow;prevent;Prevention Research;prevention service;professor;programs;Provider;Publications;Qualifying;Race;Research;Research Activity;Research Personnel;resilience;Risk;Role;Science;Scientist;senior faculty;Services;Sexual and Gender Minorities;social determinants;structural health determinants;Students;Substance Use Disorder;success;symposium;Targeted Research;Technology;Training;Training Activity;Training Programs;treatment services;United States National Institutes of Health;Viral;Work

PROJECT_TITLE: Development Core


NIH_SPENDING_CATS: Cancer;Immunotherapy;Radiation Oncology

ORG_CITY: RENTON

ORG_NAME: PROVIDENCE HEALTH & SERVICES - OREGON

ORG_STATE: WA

PHR: Project Narrative The fact that two different cancer patients can respond differently to the same therapy represents an important problem in cancer treatment. Using in depth analysis of responsive and unresponsive tumors, we have identified a novel target with the potential to help those with non-responsive tumors. We use unique and high quality preclinical models to evaluate the impact of this target on outcome, and use advanced analysis of tumors to understand the molecular regulation of the target.

PI_NAMEs: GOUGH, MICHAEL JAMES (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: adaptive immune response;adaptive immunity;Adjuvant;Affect;anti-tumor immune response;Autoimmune;Autoimmune Responses;Bioinformatics;Biological;Biological Assay;Biology;cancer cell;cancer immunotherapy;Cancer Patient;cancer therapy;Cells;Clinical;combinatorial;conditional knockout;Data;Dendritic Cells;Deoxyribonucleases;Detection;Development;DNASE1L3 deficiency;Dose;drug development;Encapsulated;Environment;Enzymes;Fractionation;Future;Genes;Goals;high reward;Immune;Immune response;Immunobiology;immunogenic;improved;In Vitro;in vivo;Infection;Innate Immune Response;innovation;Investigation;Knock-out;Link;Macrophage;Malignant Neoplasms;Measures;microvesicles;Modeling;Molecular;Mus;Myelogenous;Myeloid Cells;new therapeutic target;novel;Nucleic Acids;Outcome;pancreatic cancer model;Patients;Polynucleosome;Pre-Clinical Model;radiation response;Radiation therapy;Reagent;Regimen;Regulation;Repression;Research Design;response;Risk;Role;Sampling;Series;Signal Transduction;Stimulus;T cell response;Testing;therapeutic target;treatment effect;tumor;Tumor Immunity

PROJECT_TITLE: DNASE1L3 regulation of anti-tumor immune responses following radiation therapy


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Clinical Research;Dissemination and Implementation Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: LEE, SUNG-JAE  (contact)

PROJECT_TERMS: Adoption;AIDS prevention;Area;Assessment tool;Bayesian Modeling;Behavioral;Behavioral Research;Caliber;Cellular Phone;Collaborations;community engaged research;community partners;comorbidity;Complex;Consult;Consultations;Data;Data Analyses;data management;Databases;Decision Making;design;Development;Discipline;discrete time;Disparity;dissemination science;Educational workshop;Electronic Health Record;Elements;Environment;Epidemic;Ethnic Origin;Evaluation;Event;Fostering;Foundations;Funding;gender minority group;Grant Review;high dimensionality;HIV;Housing;implementation science;implementation study;Individual;innovation;innovative technologies;Intervention;Investigator-Initiated Research;Laboratories;Machine Learning;Manuscripts;Measurement;Measures;Mental Health;Mentors;method development;Methodology;Methods;Mission;Modeling;multiple data sources;National Institute of Mental Health;Outcome;Patient Self-Report;Persons;Preparation;Prevention;Prevention Research;prevention service;racial diversity;recruit;Recurrence;Research;Research Activity;Research Design;Research Methodology;Research Personnel;Resources;response;Sample Size;Science;Scientist;semiparametric;Services;Sexual and Gender Minorities;social determinants;Statistical Methods;structural health determinants;substance use;Surveys;Technology;Time;tool;Training;Training Activity;Transcend;treatment research;treatment services;Underrepresented Minority;virtual;webinar

PROJECT_TITLE: Methods Core


NIH_SPENDING_CATS: Biotechnology;Diabetes;Genetics;Human Genome;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Failure of pancreatic β cells underlies the progression of all forms of diabetes. We investigate critical functions of the transcription factor and diabetes gene PDX1 through intra-molecular regulation of protein stability, and inter-molecular interactions regulating subcellular/subnuclear localization, in part through phase separation. The results from these studies will deepen our fundamental understanding of Pdx1 and help to design better strategies to generate and expand β cells in vitro and in vivo, with the potential to identify new nodes for intervention to prevent or delay the onset of diabetes.

PI_NAMEs: GANNON, MAUREEN A;SOLEIMANPOUR, SCOTT ;STOFFERS, DORIS A (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: 3-Dimensional;ATAC-seq;Beta Cell;Biophysics;C-terminal;Cell Cycle;Cell Cycle Progression;Cell Line;Cell Physiology;Cell Therapy;Chromatin;Compensation;Complex;Consensus;Data;design;Development;Diabetes Mellitus;Disease;Endocrine;endocrine pancreas development;Enhancers;Epigenetic Process;Exhibits;Failure;flexibility;Gene Expression Regulation;Gene Modified;Genes;Genetic;Genetic Transcription;genome editing;Glucose;Growth;Heterozygote;homeodomain;Human;human embryonic stem cell;human pluripotent stem cell;In Vitro;in vivo;insulin promoter factor 1;insulin secretion;intermolecular interaction;Intervention;islet;islet stem cells;Islets of Langerhans;Mediating;member;Microscopy;mimetics;Molecular;Molecular Conformation;mouse model;multiple omics;Mus;Mutagenesis;Mutate;Mutation;Non-Insulin-Dependent Diabetes Mellitus;novel;Organ Size;Organogenesis;overexpression;Pancreas;pancreas development;Pathway interactions;permissiveness;Phase;Phenotype;Phosphorylation Site;Play;pluripotent stem cell differentiation;Post-Translational Protein Processing;postnatal;prediction algorithm;prevent;progenitor;programs;Proliferating;promoter;Property;protein protein interaction;Protein Region;Proteins;Publishing;Regulation;Resolution;response;Role;single nucleus RNA-sequencing;single-cell RNA sequencing;Site;Specific qualifier value;Stimulus;Structure;Structure of beta Cell of islet;Techniques;Testing;Therapeutic;transcription factor;ubiquitin-protein ligase;Ubiquitination;Work

PROJECT_TITLE: Functional interaction of transcriptional regulators in endocrine lineage specification

STUDY_SECTION: BMDM

STUDY_SECTION_NAME: Basic Mechanisms of Diabetes and Metabolism Study Section[BMDM]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: HARAWA, NINA THAWATA (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Advisory Committees;Affect;AIDS prevention;Articulation;Black race;Collaborations;Communication;Communities;community living;comorbidity;Criminal Justice;Data;Development;Disparity;Dissemination and Implementation;Economically Deprived Population;Ensure;Epidemic;epidemic preparedness;Equity;Ethnic Origin;Event;evidence base;experience;Feedback;Fostering;Gender;Generations;Health;health care service organization;health disparity;Health Policy;Healthcare;high risk;HIV;HIV disparities;HIV risk;implementation efforts;Inequity;innovation;Institution;International;investigator training;Latinx;Link;Medical;member;Mental Health;Mentors;Mission;National Institute of Mental Health;Native American population;Outcome;Persons;Policies;policy implication;Policy Maker;Policy Research;Population;pre-exposure prophylaxis;prevention service;Public Health;Race;Research;Research Methodology;Research Personnel;response;Risk;Science;Scientific Advances and Accomplishments;Sex Orientation;social determinants;social health determinants;socioeconomic disadvantage;Strategic Planning;structural health determinants;Structure;Substance Use Disorder;System;Training;Training and Education;Translating;Treatment outcome;treatment services;United States National Institutes of Health;uptake;Viral;Work

PROJECT_TITLE: Policy Impact Core


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Mental Health;Prevention;Social Determinants of Health

PI_NAMEs: REBACK, CATHY J (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Affect;AIDS clinical trial group;AIDS prevention;antiretroviral therapy;Behavior Therapy;Behavioral;Caring;Collaborations;Communities;Community Health Education;comorbidity;COVID-19;COVID-19 Prevention Network;cultural competence;Development;diversity and inclusion;Epidemic;evaluation/testing;experience;Faculty;Goals;Health;HIV;HIV Vaccine Trials Network;improved;Incidence;Individual;Inequity;innovation;integrated care;interest;Intervention;Lead;Leadership;Medical;meetings;member;Mental disorders;Mental Health;Mentors;Mentorship;Mission;mobile application;Movement;National Institute of Mental Health;next generation;Outcome;Persons;Population;prevent;Prevention;Prevention approach;Prevention Research;prevention service;Prevention strategy;preventive intervention;protective factors;Protocols documentation;Provider;Public Health;Research;Research Personnel;resilience;Risk;scale up;Science;Scientist;service organization;skills;social determinants;social health determinants;social media;social stigma;structural determinants;structural health determinants;substance use;Substance Use Disorder;symposium;Technology;Text Messaging;Therapeutic;therapy design;therapy development;Training;transmission process;treatment research;treatment services;Underrepresented Minority;United States National Institutes of Health

PROJECT_TITLE: Combination Prevention Core


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: LUBBOCK

ORG_NAME: TEXAS TECH UNIVERSITY HEALTH SCIS CENTER

PHR: Tumor cells rely upon glutamine-dependent metabolic pathways as well as serine/glycine/methionine-driven one-carbon metabolic pathway for their proliferation and growth; the amino acid transporter SLC38A5 supplies these four amino acids to triple-negative breast cancer (TNBC) cells. As TNBC has no effective targeted therapy, our goal is to show using in vitro studies with cell lines and in vivo studies with appropriate preclinical mouse models that pharmacologic blockade of SLC38A5 is a logical approach for targeted treatment of TNBC.

PI_NAMEs: GANAPATHY, VADIVEL  (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: addiction;amino acid metabolism;Amino Acid Transporter;Amino Acids;Anthelmintics;anti-cancer;Attention;Automobile Driving;Biochemical Pathway;Breast Cancer Cell;Breast Cancer cell line;cancer cell;Cancer Cell Growth;cancer therapy;Carbon;carcinogenesis;Cell Line;Cell Proliferation;Cells;chemotherapy;Clinical Trials;Coupled;Data;DNA Methylation;drug repurposing;Drug Targeting;druggable target;Epigenetic Process;Essential Amino Acids;Estrogen receptor positive;Evaluation;FDA approved;Future;Genetic;Genetic Transcription;Glutamine;Glycine;Goals;Growth;Growth and Development function;Human;In Vitro;in vivo;inhibitor;Knockout Mice;Logic;Lysine;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Neoplasms;Mediating;Metabolic Pathway;Metabolism;meter;Methionine;Methylation;Molecular;mouse model;Mus;neoplastic cell;Normal Cell;novel;nucleotide metabolism;Nude Mice;Pathway interactions;patient derived xenograft model;Pharmaceutical Preparations;pharmacologic;pre-clinical;Pre-Clinical Model;Proliferating;Protein Biosynthesis;Purines;Pyrimidine;Role;Serine;small hairpin RNA;Specificity;System;targeted treatment;Testing;Therapeutic;tool;triple-negative invasive breast carcinoma;tumor;tumor growth;Up-Regulation;uptake;WNT Signaling Pathway;Xenograft procedure

PROJECT_TITLE: Amino acid transporter SLC38A5 as a drug target for TNBC: Evaluation with genetic and pharmacologic approaches


ORG_CITY: SALT LAKE CITY

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: NARRATIVE Lung cancer is a global scourge responsible for 1.5 million patient deaths worldwide, and ~130,000 patient deaths in the USA this year alone. Despite these grim statistics, lung cancer treatment has been revolutionized by the fundamental scientific understanding that lung cancers can be genetically subdivided based on the presence of specific proto-oncogene mutations that, in turn, predict for responsiveness to FDA-approved pathway-targeted therapies. Here, we propose the use of experimental/preclinical models of KRAS- or BRAF-driven lung cancer in combination with inhibitors of cellular signaling pathways to define the importance of key pathways in lung cancer initiation, progression and therapy, with the overarching goal of developing a rational scientific foundation for the development of new combination therapy strategies to more effectively treat lung cancer patients.

PI_NAMEs: MCMAHON, MARTIN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: acquired drug resistance;AKT1 gene;anti-cancer research;antitumor effect;Asbestos;autocrine;Autophagocytosis;Behavior;Benchmarking;Biochemical;Biological;BRAF gene;cancer cell;cancer initiation;Cancer Patient;cancer therapy;cancer type;Cell Line;Cell Physiology;cell transformation;Cessation of life;Characteristics;chemotherapy;Cigarette;Clinical;clinical development;clinically relevant;comparison control;Consult;Cytoprotection;cytotoxic;Data;design;Development;Disease;Disease remission;Disease Resistance;Drug resistance;Drug Targeting;EGFR gene;Epidermal Growth Factor Receptor;ErbB Receptor Family Protein;Evaluation;Event;Family;FDA approved;Foundations;Genes;Genetic;Genetic Engineering;Genetic Transcription;Genetically Engineered Mouse;Goals;Guanosine Triphosphate;Guanosine Triphosphate Phosphohydrolases;Human;Hydroxychloroquine;Immunotherapy;ineffective therapies;inhibitor;KRAS oncogenesis;KRAS2 gene;Ligands;Lipids;Lung Adenocarcinoma;lung cancer cell;lung tumorigenesis;Maintenance;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;MAP2K1 gene;MEKs;Melanoma;Minority;Mission;Modeling;Molecular;Molecular Abnormality;mouse model;mRNA Expression;Mus;Mutation;Natural Killer Cells;neoplastic cell;new combination therapies;novel;Oncogenes;Oncogenic;Oncoproteins;Operative Surgical Procedures;pancreatic cancer patients;Pathway interactions;patient derived xenograft model;patient response;Patients;pharmacologic;Phosphotransferases;Physicians;PI3 gene;PIK3CA gene;Play;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;programs;Protein Kinase;Proto-Oncogene Proteins c-akt;Proto-Oncogenes;PTEN gene;Publishing;Radiation;Radon;RAS driven cancer;Ras Inhibitor;Receptor Protein-Tyrosine Kinases;Receptor Signaling;Research;Residual Neoplasm;Resources;response;Risk Factors;Role;Safety;Scientist;Scourge;Signal Induction;Signal Pathway;Signal Transduction;Solid;statistics;STK11 gene;success;Talents;targeted treatment;Testing;Therapeutic;tool;Toxic effect;translational impact;tumor;tumor progression

PROJECT_TITLE: Studying the initiation, progression and therapy of lung cancer in mouse models

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics - 2 Study Section[MCT2]


ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

PHR: PROJECT NARRATIVE. Many patients do not respond to immunotherapies, including immune checkpoint blockade (ICB), because their tumors are not sufficiently immunogenic, and thus go undetected by their immune systems. In this proposal, we outline a new small-molecule approach to increasing the immunogenicity of tumors by harnessing a recently-discovered inflammatory cell death modality, which we term nuclear necroptosis. The successful completion of the proposed research will outline an entirely new strategy to activate a highly inflammatory form of necroptosis and potentiate ICB-based immunotherapies, with important clinical ramifications.

PI_NAMEs: BALACHANDRAN, SIDDHARTH  (contact);STUDITSKY, VASILY M

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Abscopal effect;Adjuvant;Affinity;Agonist;anti-PD-1;Antitumor Response;Architecture;Binding;Biology;cancer immunotherapy;cancer therapy;Cell Death;Cell Death Signaling Process;cell killing;Cell Nucleus;cell type;Cells;Chromatin;Chromatin Structure;Clinical;clinically relevant;combinatorial;Cytoplasm;Data;DNA;Dose;Double-Stranded RNA;Eukaryotic Cell;Extracellular Space;Fibroblasts;Genetically Engineered Mouse;genome-wide;Genomic DNA;Goals;Histones;Immune;immune checkpoint blockade;Immune system;immunogenic;immunogenicity;Immunologic Adjuvants;Immunotherapy;improved;Inflammatory;Influenza A virus;Innate Immune Response;intercalation;Interphase Cell;Left;Ligands;Linker DNA;Malignant Neoplasms;Mediating;Melanoma;Metastatic Melanoma;Modality;Molecular Chaperones;Molecular Conformation;mouse model;neoantigens;neoplastic cell;Nuclear;Nucleosomes;Pathway interactions;Patients;Process;Proteins;recruit;Reporting;Research;RIPK3 gene;RNA;Role;Route;Rupture;sensor;Signal Pathway;Signal Transduction;small molecule;T cell response;T-Lymphocyte;Testing;theories;Treatment outcome;tumor;tumor microenvironment;Ubiquitination;UV-induced Melanoma;Viral;viral detection;viral RNA;Virus Diseases;Work;Xenograft procedure;Z-Form DNA

PROJECT_TITLE: Small-molecule exploitation of ZBP1-driven nuclear necroptosis for cancer immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-D(08)F]


NIH_SPENDING_CATS: Diabetes

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative Diabetes mellitus occurs when pancreatic beta cells fail. We have discovered that the Atf6 transcription factor, which is activated by endoplasmic reticulum stress and has been linked to human diabetes risk, increases beta cell proliferation in mouse and human beta cells. However, Atf6 activation also has harmful effects under certain conditions; this project will explore the molecular mechanisms driving benefits and harms of Atf6 activation, which we hope will form the basis for new approaches to keep beta cells thriving to prevent diabetes.

PI_NAMEs: ALONSO, LAURA C (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: ATF6 gene;Attention;Automobile Driving;base;Beta Cell;biological adaptation to stress;Biology;Cell Count;Cell Physiology;Cell Proliferation;Cell Survival;cell type;Cellular Stress;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Data;Data Set;DHFR gene;Diabetes Mellitus;diabetes pathogenesis;diabetes risk;diabetic;diabetogenic;Disease;endoplasmic reticulum stress;Engineering;experimental study;Exposure to;Failure;Frustration;Functional disorder;Future;Genetic;Genetic Transcription;genomic locus;Genomics;Glucose;Glucose Intolerance;Goals;Harm Reduction;Health;Homeostasis;Hour;Human;Impairment;improved;in vivo;insight;Insulin;Insulin-Dependent Diabetes Mellitus;islet;Islet Cell;Lasers;Lead;Learning;Link;Modeling;Molecular;Morphology;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;novel strategies;Pathway interactions;Pharmaceutical Preparations;Play;Population;Predisposition;prevent;Prevention;Process;Production;Proliferating;Proteins;Publishing;Recovery;Reporting;resilience;Resistance;response;Risk;Role;small molecule;Stimulus;Stress;Structure of beta Cell of islet;System;Technology;Testing;Therapeutic;Time;Tissues;tool;transcription factor;Uncertainty;Work

PROJECT_TITLE: Benefits and harms of activating ATF6 in beta cells


ORG_CITY: OMAHA

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative Cardiac sympathetic structural and functional changes are associated with cardiac sympathetic overactivity and arrhythmia during the progression of heart failure. This proposal will determine activation of satellite glial cells and macrophage in cardiac sympathetic ganglia and their role in cardiac sympathetic structural and functional alterations, and test the therapeutic effects of light stimulation-triggered satellite glial silencing and macrophage- related immunomodulation on ventricular arrhythmias and cardiac abnormalities in chronic heart failure. The significance of this research program is to provide the potential targets for improving cardiac sympathetic function and prognosis in patients with advanced heart failure.

PI_NAMEs: LI, YU-LONG  (contact)

PROGRAM_OFFICER_NAME: ADHIKARI, BISHOW B

PROJECT_TERMS: 3-Dimensional;Accounting;Adult;American;Anesthesia procedures;Animals;Arrhythmia;Astrocytes;Biological;Biological Products;Brain;Cardiac;Cell membrane;Cells;Central Nervous System;Colony-Stimulating Factor Receptors;Computer software;Congestive Heart Failure;Connexin 43;Conscious;Coronary artery;cytokine;Data;design;Electrochemistry;Electrophysiology (science);Encapsulated;Enteral;Enzymes;Functional disorder;Glial Fibrillary Acidic Protein;Goals;Heart;Heart Abnormalities;Heart failure;heart failure with reduced ejection fraction;heart function;heart imaging;Hyaluronic Acid;Hydrogels;Hyperactivity;immunoregulation;improved;Inflammatory;inhibitor;Injectable;Laboratory Research;Ligation;Light;light effects;Link;Macrophage;Macrophage Activation;Macrophage Colony-Stimulating Factor Receptor;Malignant - descriptor;Mediating;Membrane;Modeling;Molecular Genetics;mortality;Multiple Sclerosis;Myocardial Infarction;Myocardium;Nerve;Neuroglia;Neuronal Dysfunction;Neurons;Neurotransmitters;Norepinephrine;novel;Opsin;optogenetics;Patients;Peripheral;Peripheral Nervous System;Production;Prognosis;programs;Proliferating;promoter;Protein Kinase C;Proton Pump;Public Health;Publishing;Rattus;receptor;reconstruction;Regulation;Reporting;Research;Research Project Grants;Role;sham surgery;Signal Pathway;Slice;Structure of stellate ganglion;sudden cardiac death;Sympathetic Ganglia;System;Techniques;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic target;therapeutically effective;Tissues;TNF gene;TNF-alpha converting enzyme;tool;Transfection;Ventricular;Ventricular Arrhythmia;Vision;Work

PROJECT_TITLE: Mechanisms of cardiac sympathetic hyperactivity in chronic heart failure

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Fragile X Syndrome (FXS), the most frequent monogenic cause of Autism Spectrum Disorder (ASD), results from deficiency in the Fragile X Mental Retardation Protein (FMRP) which alters cellular protein synthesis and produces an overgrowth of neurons and synaptic connections accompanied by cognitive and behavioral phenotypes. Molecular mechanisms coupling the FMRP protein to specific programs of protein synthesis which could underlie FXS-associated deficits are incompletely understood. In this proposal, we use mouse and human models to conduct a genome-wide investigation of post-transcriptional gene regulation by small RNA pathways which serve as network regulators of specificity in protein synthesis, and seek to define the potential for manipulation of these pathways to impact phenotypes resulting from the loss of FMRP.

PI_NAMEs: MEFFERT, MOLLIE KATHERINE (contact)

PROGRAM_OFFICER_NAME: LEINWAND, SARAH GOLDBERG

PROJECT_TERMS: Affect;autism spectrum disorder;Behavioral;behavioral phenotyping;Binding Proteins;Biochemical;Biogenesis;Brain;brain abnormalities;cell type;Central Nervous System;Child;Chimera organism;Cognitive;cognitive function;Complex;Coupling;crosslink;Data;Data Set;Detection;Development;Diagnostic;excitatory neuron;Family;FMR1 gene;Fragile X Syndrome;Functional disorder;Gene Expression Regulation;gene repression;Gene Targeting;Genes;Genetic Diseases;genetic regulatory protein;genome-wide;Goals;Growth;High-Throughput Nucleotide Sequencing;Human;human model;human stem cell-derived;Hyperactivity;Immunoprecipitation;Impairment;in vivo;Incidence;induced pluripotent stem cell;Intellectual functioning disability;interest;Intervention;Investigation;Knock-out;Knockout Mice;Knowledge;Ligation;Link;MAP Kinase Gene;MAPK3 gene;Mediating;Messenger RNA;MicroRNAs;Molecular;Molecular Target;Morphology;Motivation;mouse model;Mus;Nervous System Disorder;neural;Neuroanatomy;Neurodegenerative Disorders;Neurodevelopmental Disorder;neuronal growth;Neurons;Pathway interactions;Patients;Phenotype;Post-Transcriptional Regulation;posttranscriptional;Production;programs;Protein Biosynthesis;Protein Deficiency;protein function;protein phosphatase inhibitor-2;Proteins;repetitive behavior;Repression;Resistance;restoration;RNA Binding;RNA-Binding Proteins;RNA-Induced Silencing Complex;Signal Transduction;Small RNA;social communication;Social Interaction;Specificity;Synapses;Techniques;Testing;Time;Transcript;Translations;Untranslated RNA;Validation

PROJECT_TITLE: Defining post-transcriptional gene regulation in FMRP-deficiency usingmiRNA:target chimeras


ORG_CITY: SAINT LOUIS

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project narrative This proposal will study the molecular mechanisms that connect neurons together to form synapses. We will focus on how specific molecules direct the assembly of pain-processing circuits in the spinal cord to better understand how these processes are altered in neurodevelopmental disorders and go awry during the development chronic pain.

PI_NAMEs: COPITS, BRYAN  (contact)

PROGRAM_OFFICER_NAME: GREENWELL, THOMAS

PROJECT_TERMS: abuse liability;Affect;American;autism spectrum disorder;Axon;Behavior;behavioral phenotyping;Binding;Biological Assay;Biology;Brain;Cell Adhesion Molecules;Central Nervous System;central pain;chronic pain;Coculture Techniques;comorbidity;Complex;conditional knockout;Dangerousness;Development;Diabetes Mellitus;Disease;effective therapy;Electrophysiology (science);Ensure;Esthesia;Event;experimental study;Family;Fibroblasts;Future;Gene Family;Heart Diseases;In Vitro;in vivo;Inflammation;insight;Investigation;knockout gene;Knockout Mice;Label;Ligands;Link;Maintenance;Malignant Neoplasms;Modality;Molecular;Mus;Nerve;nerve supply;Nervous System;Neurodevelopmental Disorder;Neurons;Neurosciences;Nociception;Nociceptors;optogenetics;pain behavior;pain processing;Patients;Perception;Peripheral;Peripheral Nervous System;Persons;Phenotype;Physiology;Positioning Attribute;Postdoctoral Fellow;postsynaptic;prescription opioid;presynaptic;Presynaptic Terminals;Process;Property;Protein Isoforms;Public Health;Quality of life;Role;Sensory;sensory integration;Sensory Process;Slice;somatosensory;Specific qualifier value;Spinal;Spinal Cord;Stimulus;success;Synapses;synaptic function;synaptogenesis;System;Testing;Training;Trauma;Viral;Viral Vector;Work

PROJECT_TITLE: Synaptic mechanisms of somatosensory circuit assembly

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Neurodegenerative;Neurosciences;Prevention

ORG_CITY: IRVINE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

PHR: PROJECT NARRATIVE. The proposed research uses computational modeling and neuroimaging to examine how episodic memory and reinforcement learning contribute to decision-making and choice behavior across the lifespan. In doing so, this research can inform development of targeted interventions that can improve age-related declines in learning and decision making behaviors for healthy older adults and various clinical populations. Findings from this research will provide important insights into helping older adults and individuals with learning and memory impairments due to neurological disorders or age-related cognitive dysfunction such as stroke, Alzheimers disease, and related dementias by identifying specific areas in memory and reinforcement learning that can be improved.

PI_NAMEs: NOH, SHARON M (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: Address;Affect;Age;age difference;age related;age related changes;age related decline;age-related disease;Aging;aging population;Alzheimer's disease patient;Alzheimer's disease related dementia;Area;Behavior;behavior measurement;Choice Behavior;Clinical;cognitive ability;Cognitive aging;Compensation;Complex;computational basis;Computer Models;Decision Making;Development;Early Diagnosis;Early Intervention;Early treatment;Educational Intervention;Episodic memory;expectation;experience;experimental study;Face;Failure;Functional disorder;Functional Magnetic Resonance Imaging;healthy aging;Hippocampus;human old age (65+);Impaired cognition;Impairment;improved;Individual;Individual Differences;insight;Intervention;Learning;life span;Love;Measures;Memory;memory encoding;Memory impairment;Memory Loss;memory process;Modeling;Nervous System Disorder;neural;neural circuit;neural patterning;neuroimaging;neuromechanism;older adult;Older Population;Participant;Pattern;Play;Population;Process;Psychological reinforcement;Recording of previous events;recruit;Research;Resolution;Rewards;Role;Running;Sampling;Shapes;Stroke;support network;System;theories;Time;Variant;Work;young adult

PROJECT_TITLE: Age-related changes in memory alter decision-making


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Breast Cancer;Cancer;Cancer Genomics;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE African American women are two to three times more likely than European American women to get the most aggressive subtype of breast cancer, but the reasons for this disparity are not well understood. This project investigates how chemical exposures to which African American women are disproportionately exposed may promote the development of aggressive breast cancers.

PI_NAMEs: COLACINO, JUSTIN ADAM (contact)

PROGRAM_OFFICER_NAME: BOYLES, ABEE

PROJECT_TERMS: African American Women;aggressive breast cancer;American;Award;Basal Cell;Biological Markers;Biology;black women;Breast;breast stem cell;Cancer Biology;cancer health disparity;Carcinogens;Cell Reprogramming;Cells;Characteristics;chemical association;Chemical Exposure;Chemicals;Chromatin;cohort;Communities;community engagement;community partners;Complex;Data;Data Set;Development;Diagnosis;Dichlorodiphenyl Dichloroethylene;Diet;Disparity;Dose;Environment;epidemiologic data;Epidemiology;epidemiology study;Epigenetic Process;Epithelium;Etiology;European;Evaluation;Exercise;exposed human population;Exposure disparity;Exposure to;functional outcomes;Gene Expression Profile;Genes;Genetic;Genetic Transcription;Goals;health disparity;Health Services Accessibility;Heavy Metals;Human;Hybrid Cells;Hybrids;Image;In Vitro;Individual;individualized prevention;insight;Lead;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mesenchymal;Methods;Michigan;Molecular;Molecular Epidemiology;molecular marker;Molecular Profiling;Molecular Target;molecular targeted therapies;mortality;mortality risk;novel strategies;Outcome;outcome disparities;Parabens;Pathway interactions;Pesticides;Phenotype;phthalates;Poly-fluoroalkyl substances;Precision therapeutics;Prevention strategy;racial disparity;Reproductive History;Research;Scientist;social health determinants;stem;stem cell expansion;stem cells;stemness;Testing;Toxic effect;toxicant;Toxicology;transcriptomic profiling;transcriptomics;translational impact;treatment strategy;triple-negative invasive breast carcinoma;Update;Validation;White Women;Woman

PROJECT_TITLE: Developmental Exposures, Stem Cell Reprogramming, and Breast Cancer Disparities

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OBT-Y(55)R]


NIH_SPENDING_CATS: Clinical Research;Genetics;Kidney Disease;Organ Transplantation;Transplantation

PHR: Project Narrative In order to meet the growing demands for organs suitable for kidney transplantation, novel methods are needed to assess the quality donor kidneys. This project aims to bring new tools to transplant professionals to improve our ability to evaluate donor kidneys, reduce organ discard of suitable kidneys and increase deceased donor kidney transplantation. Additionally, we will advance our understanding of donor kidney biology from a more genetically and racially diverse patient population.

PI_NAMEs: PARIKH, CHIRAG R (contact)

PROJECT_TERMS: Acute Renal Failure with Renal Papillary Necrosis;Admission activity;Affect;Algorithms;Allografting;APOL1 gene;Biological Markers;Biological Process;Biology;Black race;Cessation of life;Clinical Data;cohort;Cohort Studies;Collaborations;Creatinine;delayed graft function;Devices;Enrollment;Epidemiology;Evaluation;experimental arm;Failure;Functional disorder;Funding;Genetic;Genetic Models;Genetic Risk;Genotype;graft failure;graft function;high risk;Hospitalization;improved;Incidence;indexing;Inferior;Injury;injury and repair;Injury to Kidney;insight;Kidney;Kidney Transplantation;Knowledge;Laboratories;lateral flow assay;Measurement;Measures;Methods;Natural History;novel;novel strategies;Organ;organ allocation;Organ Donations;Organ Procurements;osteopontin;Outcome;patient population;Patients;Phase;Phenotype;point of care;point of care testing;predictive modeling;Predisposition;Prevalence;Process;prospective;protective effect;Race;racial diversity;rapid testing;Renal function;repaired;Reperfusion Injury;Research;Resources;response;Risk;risk variant;Sampling;Science;Serum;Site;System;Time;tool;Translational Research;transplant centers;Transplantation;UMOD gene;United Network for Organ Sharing;United States National Institutes of Health;urinary;Urine;Waiting Lists

PROJECT_TITLE: Novel Kidney Injury Tools in Deceased Organ Donation to Predict Graft Outcomes

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]