NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: ALACHUA

ORG_NAME: NANOTHERAPEUTICS, INC.

ORG_STATE: FL

PI_NAMEs: SCHOLZ, ISABEL  (contact)

PROJECT_TERMS: analytical method;assay development;Attenuated;Biological Products;Biotechnology;Development;Development Plans;Documentation;Evaluation;Formulation;Infectious Diseases Research;Influenza Therapeutic;manufacture;Monoclonal Antibodies;Nucleic Acids;Peptides;Plasmids;preclinical development;Process;product development;Recombinant Proteins;service programs;Services;Small Interfering RNA;Therapeutic;therapeutic development;Translational Research;vector

PROJECT_TITLE: Task C2: Analytical Method, Process Development and Manufacturing for Therapeutics


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON SBIR/STTR CONTRACTS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Biodefense and Related Countermeasures;Biotechnology;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: BALTIMORE

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE COUNTY

ORG_STATE: MD

PI_NAMEs: SORENSON, GREGORY  (contact)

PROJECT_TERMS: Acute Pneumonia;Adjuvant;Adult;aging population;Agonist;alpha Toxin;Antigen Targeting;Antigens;Bacterial Proteins;biophysical properties;Chimeric Proteins;combinatorial chemistry;Contractor;Development;Dose;Drug Metabolic Detoxication;Elderly;Formulation;Helper-Inducer T-Lymphocyte;Hemagglutinin;Hemolysin;Humoral Immunities;Immune;Immunity;Immunocompetent;immunogenic;immunogenicity;Immunologic Adjuvants;Immunologics;Individual;Influenza;Influenza A virus;influenza virus vaccine;Innate Immune System;Ligands;Lipid A;Lung;Mediating;Modeling;novel vaccines;old mice;Population;Preclinical Testing;Process;Production;Proliferating;Proteins;Pseudomonas;Pseudomonas aeruginosa;rational design;response;Safety;Shapes;Signal Transduction;Staphylococcus aureus;Staphylococcus aureus infection;System;T-Lymphocyte;Technology;TLR4 gene;Type III Secretion System Pathway;Vaccine Adjuvant;Vaccine Antigen;vaccine formulation;vaccine immunogenicity;Vaccines;Viral Proteins

PROJECT_TITLE: Adjuvant Development of the TLR4 Ligand BECC470s For Use in Influenza, S. aureus, and P. aeruginosa Vaccines


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: CHICAGO

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PI_NAMEs: EL-KAMMASH, BRUXANNE  (contact)

PROJECT_TERMS: Adjuvant;Agonist;Antibodies;Antibody titer measurement;Antigens;Chemical Structure;Chemistry;Contractor;Contracts;Development;Disease;efficacy study;Emulsions;Ferrets;Fluzone;Formulation;Goals;Good Manufacturing Process;Immune response;Immune system;immunogenicity;Immunologic Stimulation;Immunologics;Immunomodulators;improved;Inflammation;Influenza;Influenza A Virus, H1N1 Subtype;Influenza A Virus, H3N2 Subtype;Influenza B Virus;influenza virus vaccine;inhibitor;Knowledge;Laboratories;lead candidate;Liposomes;manufacture;Messenger RNA;Modeling;Modification;Molecular;Mus;National Institute of Allergy and Infectious Disease;Oils;Outcome;Parents;Performance;performance tests;prevent;Production;Property;Recombinants;Research;RNA vaccine;side effect;Structure;System;Testing;TLR7 gene;Toxicity Tests;Toxicology;Translations;vaccine development;vaccine platform;Vaccines;Water

PROJECT_TITLE: DEVELOPMENT OF VACCINES FOR INFLUENZA USING AN IMMUNO-MODULATOR ADJUVANT AND MULTI-PLATFORM APPROACH


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Biotechnology;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related

ORG_CITY: PLAN-LES-OUATES

ORG_COUNTRY: SWITZERLAND

ORG_FIPS: SZ

ORG_NAME: VACCINE FORMULATION INSTITUTE (CH) LTD

PI_NAMEs: COLLINS, NICOLAS  (contact)

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Adjuvant;Advanced Development;Antigens;Chromatography;Clinical Research;Communities;Contractor;cost effective;Development;efficacy study;Evaluation;Formulation;global health;Good Manufacturing Process;Hamsters;immunogenicity;Immunologic Adjuvants;innovation;liposome vector;Liposomes;Macaca mulatta;manufacture;Mus;nanoparticle;novel vaccines;Pharmacology;Phase;preclinical study;Preparation;protective efficacy;QS21;Quillaja;Safety;Saponins;Sarbecovirus;sarbecovirus vaccine;SARS coronavirus;Soapbush;Toxic effect;Toxicology;vaccine access;Vaccine Adjuvant;vaccine development;vaccine efficacy;Vaccines

PROJECT_TITLE: ADVANCED DEVELOPMENT OF LQ A LIPOSOME-BASED SAPONIN-CONTAINING ADJUVANT FOR USE IN PANSARBECOVIRUS VACCINES


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: SPRINGFIELD

ORG_NAME: NORTH AMERICAN ASSN/CENTRAL CANCER REG

PI_NAMEs: KOHLER, BETSY  (contact)

PROJECT_TERMS: American;Area;Cancer Surveillance Research Program;Collaborations;Contracts;data registry;improved;Malignant Neoplasms;Methods;National Cancer Institute;neoplasm registry;operation;Registries;Research;Services;surveillance data

PROJECT_TITLE: TASK ORDER 75N91021F00001 FOR SUPPORT SERVICES FOR DEVELOPING AND PROMOTING METHODS AND STANDARDS FOR CANCER REGISTRY OPERATIONS AND SURVEILLANCE DATA


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Contraception/Reproduction;Obesity;Patient Safety;Prevention;Women's Health Research

ORG_CITY: NORFOLK

ORG_NAME: EASTERN VIRGINIA MEDICAL SCHOOL

ORG_STATE: VA

PI_NAMEs: ARCHER, DAVID  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - EAST VA


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PI_NAMEs: TUROK, DAVID  (contact)

PROJECT_TERMS: Clinical Trials Network;Conduct Clinical Trials;Contraceptive Agents;Contraceptive methods;Development;Female Contraceptive Agents;Future;Goals;Medical;Methods;Mission;National Institute of Child Health and Human Development;Obesity;product development;Program Development;protocol development;Protocols documentation;Risk Reduction;Services;Site;unintended pregnancy;Utah;venous thromboembolism;Woman

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - UTAH


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PI_NAMEs: TEAL, STEPHANIE  (contact)

PROJECT_TITLE: CCTN-CONTRACEPTIVE DEVELOPMENT PROGRAM – CORE FUNCTION ACTIVITIES FOR SITES OF FEMALE CONTRACEPTIVE STUDIES - CU DENVER


NIH_SPENDING_CATS: Cancer;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Pediatric Cancer;Rare Diseases;Social Determinants of Health

PROJECT_TERMS: Data;data infrastructure;data registry;Data Sources;financial toxicity;Genomics;heterogenous data;Infrastructure;Malignant Childhood Neoplasm;Malignant Neoplasms;Measures;neoplasm registry;Oral;Outcome;pediatric patients;Recording of previous events;Recurrence;social health determinants;tumor

PROJECT_TITLE: NATIONAL CHILDHOOD CANCER REGISTRY (NCCR)


NIH_SPENDING_CATS: American Indian or Alaska Native;Breast Cancer;Cancer;Cancer Genomics;Genetics;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: CALVERTON

ORG_NAME: INFORMATION MANAGEMENT SERVICES, INC.

PI_NAMEs: STINE, MEGAN  (contact)

PROJECT_TERMS: Alaska Native;American Indians;Black race;breast malignancies;Clinical Data;Colon;Data;data centers;Databases;early onset;genomic data;Hispanic;human subject;Informatics;Kidney;Liver;Malignant Neoplasms;Multiple Myeloma;Not Hispanic or Latino;Population Heterogeneity;prospective;Prostate;Protocols documentation;Services;The Cancer Genome Atlas;Tissue Procurements;Underrepresented Populations;Validation

PROJECT_TITLE: EARLY ONSET MALIGNANCIES INITIATIVE CLINICAL DATA CENTER


PI_NAMEs: KPHLER, BETSY  (contact)

PROJECT_TERMS: American;Dedications;Funding;Location;Malignant Neoplasms;Methodology;minimal risk;National Cancer Institute;neoplasm registry;Process;Registries;Research Personnel;surveillance data;System;virtual

PROJECT_TITLE: VIRTUAL POOLED REGISTRY (VPR) PROJECT


ADMINISTERING_IC: VA

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: Veterans Affairs

ORG_CITY: Aurora

ORG_NAME: VA EASTERN COLORADO HEALTH CARE SYSTEM

PHR: The incidence of melanoma is increasing rapidly in VA population in the United States, and sun exposure during US military service has been linked to increased melanoma incidence. The standard of care for advanced melanoma currently includes molecular-targeted therapies of BRAF and MEK inhibitors, as well as immunotherapies with checkpoint inhibitors such as anti-PD1. However, many melanoma patients either do not respond or relapse from the current treatments. Therefore, discovering new effective therapies for malignant melanoma is still a pressing issue in the VA patient care mission. The objective of this project is to discover the therapeutic potential of the new generation of clinical-trial-ready drugs targeting pro-survival proteins to treat melanoma by inducing apoptosis, especially for tumors from patients unresponsive to current treatments. The results will likely lead to clinical trials testing an exciting new generation of treatments for melanoma.

PI_NAMEs: NORRIS, DAVID A.;SHELLMAN, YIQUN G (contact)

PROJECT_TERMS: Acute Myelocytic Leukemia;anti-PD-1;anti-PD1 therapy;anti-tumor immune response;Apoptosis;Apoptotic;BCL1 Oncogene;BCL2 gene;BCL2L1 gene;BRAF gene;cancer cell;cancer therapy;CD8-Positive T-Lymphocytes;Cells;Clinical;clinical trial readiness;Clinical Trials;Collection;Colorado;Combined Modality Therapy;conventional therapy;Data;design;Drug Combinations;Drug Targeting;effective therapy;effectiveness evaluation;efficacy evaluation;efficacy testing;exhaust;exosome;Family;Family member;Generations;Hematologic Neoplasms;Immune;Immune checkpoint inhibitor;Immunocompetent;immunogenicity;Immunotherapy;implantation;improved;improved outcome;In Vitro;in vivo;Incidence;Induction of Apoptosis;inhibitor;Link;MCL1 gene;MEKs;Melanoma;Melanoma Cell;Melanoma patient;Melanoma Tumor;member;military service;mimetics;Mission;Modeling;molecular targeted therapies;mouse model;Mus;neoplastic cell;novel;novel therapeutics;Outcome;Patient Care;patient derived xenograft model;Patient-Focused Outcomes;Patients;Play;Population;potential biomarker;predictive marker;Probability;Proteins;Relapse;Resistance;responders and non-responders;response;Role;small molecule inhibitor;Solid Neoplasm;standard care;standard of care;Sun Exposure;Testing;Therapeutic;therapy development;therapy resistant;Tissue Banks;transcriptome sequencing;Treatment Effectiveness;tumor;Tumor Debulking;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells;United States;Universities;Xenograft Model

PROJECT_TITLE: Melanoma Resistance to Apoptosis: Mechanisms and Therapeutic Potential


ADMINISTERING_IC: OD

FUNDING_MECHANISM: OTHERS

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

NIH_SPENDING_CATS: Aging;Data Science;Networking and Information Technology R&D (NITRD)

ORG_CITY: CHANTILLY

ORG_NAME: FOUR POINTS TECHNOLOGY, LLC

PI_NAMEs: LIPKIN, JOEL A (contact)

PROGRAM_OFFICER_NAME: WEBER, MICHAEL NICHOLAS N

PROJECT_TERMS: Acceleration;Address;Biomedical Research;Cloud Computing;Cloud Service;cloud storage;Communities;computerized tools;Data;Data Commons;data ecosystem;data repository;Data Science;Data Set;Economics;FAIR principles;Funding;Goals;Image;Individual;large datasets;Modeling;Modernization;Phase;Policies;Procedures;Process;programs;Research Infrastructure;Research Personnel;Science;Series;service providers;Services;Strategic Planning;Technology;Testing;United States National Institutes of Health;Work

PROJECT_TITLE: STRIDES


ADMINISTERING_IC: TW

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research

ORG_CITY: NAIROBI

ORG_COUNTRY: KENYA

ORG_FIPS: KE

ORG_NAME: AGA KHAN UNIVERSITY (KENYA)

PHR: NARRATIVE Research administration is a critical but often under-resourced function required for the successful administration and execution of large, complex NIH grants in Africa and other low- and middle-income countries (LMIC). The overall objective of this administrative supplement is to develop a more comprehensive and efficient research administration function at the Aga Khan University to support the development, submission, and successful administration of research grants. The proposed work is highly synergistic with DS- I Coordinating Center and Research Administrator Working Group activities aimed to support research administration functions with the consortium and can serve as a framework for standard research administration services that can be scaled/adapted to the needs of DS-I Africa members.

PI_NAMEs: ALI, AMINA ABUBAKAR (contact);WALJEE, AKBAR K

PROGRAM_OFFICER_NAME: NEWSOME, BRAD

PROJECT_TERMS: Address;Administrative Supplement;Administrator;Africa;African;Area;Artificial Intelligence;base;Child Health;cloud based;Collaborations;Communication Tools;Communities;Community of Practice;Complex;Data;Data Science;Dedications;Development;Educational Curriculum;empowerment;Flowcharts;Fostering;Funding;Future;Grant;Growth;Health;Hybrids;improved;Industry;Institution;interest;International;Joints;Knowledge;Learning;learning network;learning progression;Letters;Life Cycle Stages;low and middle-income countries;machine learning method;Maps;Maternal Health;member;Mental Health;Mentorship;Michigan;Needs Assessment;neonatal health;novel strategies;online community;operation;Outcome;parent project;Periodicals;Persons;Phase;Process;programs;Research;research faculty;Research Personnel;Research Project Grants;Research Support;Resources;response;Role;Seasons;Services;Site Visit;Standardization;Strategic Planning;System;Touch sensation;Training;Training Activity;training opportunity;United States National Institutes of Health;Universities;virtual;Work;working group;Workload

PROJECT_TITLE: Enhancing research administration capacity within the DS-I Africa Consortium: An initiative with The Aga Khan University and the University of Michigan

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(70)-R]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: This proposal provides scientific rationale and an empirical basis for targeting basal forebrain parvalbumin neurons (BF PV) to treat Alzheimer's disease (AD). This research will inform innovative treatment strategies by showing that BF PV excitation can be used to prevent the progression of AD pathology and restore hippocampal-cortical network integrity to rescue cognition.

PI_NAMEs: SCHIFFINO, FELIPE LOPES (contact)

PROGRAM_OFFICER_NAME: SUTTERER, MATTHEW

PROJECT_TERMS: 3xTg-AD mouse;Abeta clearance;abuse liability;Acute;Affect;Aftercare;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Amyloid beta-Protein;Amyloid deposition;Amyloidosis;Area;Association Learning;Attention;Award;basal forebrain;Behavioral;behavioral outcome;Boston;Career Mobility;Chronic;Cognition;cognitive enhancement;Communication;comparative efficacy;Coupling;Data;Dementia;Disease;Dorsal;Education;education research;Electroencephalography;experimental study;Funding;Genetic;Goals;Hippocampus;Impaired cognition;Impairment;improved;improved outcome;innovation;Institution;Interneurons;Ipsilateral;J20 mouse;Lasers;Learning;learning strategy;Massachusetts;Measures;Medial;Mediating;medical schools;member;Memory;Memory impairment;Mentors;Mentorship;Methods;Modeling;Motivation;mouse model;Mus;neural;Neurons;neuroprotection;optogenetics;Paper;Parietal Lobe;Parvalbumins;Pathogenesis;Pathologic;Pathology;Pathway interactions;pharmacologic;Phase;Physiologic pulse;pre-clinical;preclinical study;Prefrontal Cortex;prevent;professor;programs;Property;Proteins;Psychological reinforcement;Recovery of Function;Regulation;repaired;Research;Research Personnel;Same-sex;Senile Plaques;sensory stimulus;Short-Term Memory;side effect;synergism;Task Performances;Tauopathies;Techniques;Testing;Therapeutic;Training;Treatment Efficacy;treatment strategy;Universities;Visual;Visual Cortex;β-amyloid burden

PROJECT_TITLE: Controlling oscillations to treat Alzheimers disease targeting the basal forebrain parvalbuminsystem

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Diabetes;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: EAST LANSING

ORG_DEPT: PHYSIOLOGY

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: PROJECT NARRATIVE Cognitive decline is a severe complication of obesity, the metabolic syndrome, prediabetes, and diabetes, all of which are potentially linked by inflammation. In this proposal, we will identify a timeline of inflammatory events in mid to later life obesity- and prediabetes-mediated cognitive decline, with particular focus on the contribution of the innate inflammatory cGAS/STING pathway, to identify pathological mechanisms of microglial-mediated inflammatory crosstalk. Our goal is to identify disease-modifying targets and ideal therapeutic windows for obesity- and prediabetes-related cognitive decline during aging.

PI_NAMEs: ELZINGA, SARAH  (contact)

PROGRAM_OFFICER_NAME: FRANKOWSKI, DAVID WITT

PROJECT_TERMS: Acute;Affect;Age;Age-associated memory impairment;Aging;aging population;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Anti-Inflammatory Agents;Bacteria;Brain;career;Cell Aging;Cells;Central Nervous System;Child;Chronic;Clinical;Cognition;Cognitive;cognitive change;Communication;Complication;cytokine;Cytokine Gene;Data;Dementia;dementia burden;Development;Diabetes Mellitus;Diabetic mouse;Diet;Disease;druggable target;ds-DNA;Dyslipidemias;Early Intervention;Early treatment;effective therapy;Etiology;Event;extracellular vesicles;Foundations;Future;Gene Expression;Goals;High Fat Diet;Hippocampus;Immune;Immune system;Impaired cognition;In Vitro;in vivo;Individual;Inflammaging;Inflammation;Inflammatory;inflammatory milieu;Insulin;Insulin Resistance;interest;knockout animal;Knockout Mice;Knowledge;late life;Link;loss of function;Measures;Mediating;Mentors;Metabolic;Metabolic dysfunction;Metabolic syndrome;Microglia;middle age;Mitochondria;Modeling;Molecular;Mus;Nervous System Trauma;Neurologic;Neurons;novel;Nuclear;obese patients;Obesity;older adult;Outcome;Pathogenesis;Pathologic;Pathway interactions;Peripheral;Phase;Play;Population;Positron-Emission Tomography;Prediabetes syndrome;Predisposing Factor;Proteins;Research;Research Personnel;Role;Saturated Fatty Acids;Signal Transduction;single-cell RNA sequencing;stem;Stimulator of Interferon Genes;Stress;Techniques;Testing;Therapeutic;Time;timeline;Tissues;Training;transcriptomics;translatable strategy;transmission process;United States;Virus

PROJECT_TITLE: Midlife obesity and prediabetes trigger later life cognitive decline through central nervous system inflammaging and innate immune dysregulation of cGAS/STING


ED_INST_TYPE: SCHOOLS OF MEDICINE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Although, increased DNA breaks within the genome are associated with Alzheimer’s disease and brain aging, the molecular mechanisms of this association remain unclear. I propose to use cutting-edge tools to measure the impact of DNA breaks on genome organization to understand the mechanisms of how DNA breaks lead to Alzheimer’s disease, and test the therapeutic potential of these pathways. The proposal is relevant to public health and the mission of the NIA because it improves our fundamental understanding about the biology of Alzheimer's disease with the goal of developing therapeutic interventions.

PI_NAMEs: DILEEP, VISHNU  (contact)

PROGRAM_OFFICER_NAME: GRAY, ERIN EMILY

PROJECT_TERMS: 3-Dimensional;Adopted;Advisory Committees;Aging;aging brain;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;ATAC-seq;Autopsy;Biological Assay;Biology;Brain;cell type;Cells;ChIP-seq;Chromatin;Chromosomal translocation;chromosome conformation capture;Coculture Techniques;cohesin;Complex;computational pipelines;Data;Development;Disease;Disease associated microglia;DNA;DNA Binding;DNA Damage;DNA Double Strand Break;experience;familial Alzheimer disease;Frequencies;Gene Expression;Genome;Genome Stability;Genomic Instability;Genomics;Goals;Hi-C;Human;human induced pluripotent stem cells;Hyperactivity;Immediate-Early Genes;improved;In Situ;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;induced pluripotent stem cell technology;Knockout Mice;Label;Lead;Location;Measures;Mediating;Mentors;Mentorship;Microglia;Mission;Modeling;Molecular;Mosaicism;mouse model;Mus;Mutation;Nerve Degeneration;Nervous System Disorder;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;Neurons;Nonhomologous DNA End Joining;novel;novel therapeutics;Oligodendroglia;Orthologous Gene;Partner in relationship;Pathogenesis;Pathologic;Pathway interactions;Pattern;pharmacologic;Phase;Play;Predictive Factor;presenilin-1;prevent;programs;promoter;Public Health;Publishing;Recurrence;Reporting;Repression;response;Role;single cell analysis;single-cell RNA sequencing;Sorting;tau Proteins;Tauopathies;Technology;Testing;therapeutic evaluation;Therapeutic Intervention;tool;Training;transcription factor;transcriptome;Work

PROJECT_TITLE: Impact of DNA double-strand breaks on 3D genome organization and genome stability in Alzheimer's disease


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Nutrition;Prevention;Social Determinants of Health

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE  Social adversity and certain unhealthy diets are both associated with increased risk of mortality, poorer health outcomes, and higher incidences of neurodegenerative diseases such as Alzheimer's disease. The project investigates how common mechanisms—for instance in inflammatory responses to chronic stress—might enable the development of dietary interventions that buffer against the negative consequences of adverse social environments. Its results will greatly advance our understanding of the role that diet and the social environment play in resilience during aging.

PI_NAMEs: CHIOU, KENNETH LYU (contact)

PROGRAM_OFFICER_NAME: SARE, RACHEL

PROJECT_TERMS: Acceleration;Acute;Address;Adult;Adult women;adverse outcome;Affect;Age;age acceleration;age related;age related changes;age related decline;age related neurodegeneration;Aging;aging brain;aging population;Alcoholism;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease related dementia;Alzheimer's disease risk;Amygdaloid structure;Animal Model;Attenuated;behavior influence;Biological;biological adaptation to stress;Biology;Brain;brain cell;brain health;Brain region;Buffers;career;cell type;Cells;Characteristics;Chronic;Chronic Disease;Chronic stress;Cognitive;cohort;Collaborations;Dementia;design;Development;Diet;dietary;Dietary Intervention;Disease;Disparity;entorhinal cortex;Environment;Environmental Risk Factor;Exhibits;experience;Faculty;Gene Expression;Gene Expression Regulation;Genetic Transcription;genome-wide;Genomics;Glean;Goals;Health;Hippocampus;Human;human model;human old age (65+);Hypothalamic structure;Immune;Immune response;Incidence;Individual;Inflammation;Inflammatory;inflammatory modulation;Inflammatory Response;insight;Intervention;life span;Link;Longevity;Macaca;Mammals;Measurement;Mediterranean Diet;Mentors;Microglia;middle age;Modeling;Molecular;mortality;mortality risk;Nerve Degeneration;Neurodegenerative Disorders;neuroinflammation;Neurologic;neuropathology;Neurosciences;nonhuman primate;Nutritional;Obesity;Outcome;Pathology;Pathway interactions;Phenotype;Physiological;Play;poor health outcome;Population;Population Control;Prefrontal Cortex;Primates;programs;Psychophysiology;rate of aging;Research;resilience in aging;response;Role;Sampling;Shapes;single-cell RNA sequencing;Smoking;social;social adversity;Social Behavior;Social Environment;Social Gradients;social influence;Social outcome;social relationships;Social Sciences;Social status;social stress;social stressor;Stimulus;stimulus processing;Stress;study population;System;Testing;therapy development;Training;Training Activity;Trauma;Unhealthy Diet;Up-Regulation;Variant;western diet;Women's Group;Women's study;Work

PROJECT_TITLE: Social and dietary modifiers of neuroinflammation and aging


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Kidney Disease

ORG_CITY: STANFORD

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This R25 application proposes a new research training program in the NIDDK/KUH mission areas of adult and pediatric nephrology and adult and pediatric (benign) urology. Our Nephrology and Urology training program has successfully trained fellows for careers in academics in basic, translational, and clinical research, while focused on diversity recruitment and retention. For this undergraduate initiative, we have utilized best practices from our teaching and mentoring experience for kidney scientists and leveraged the strengths of the Stanford School of Medicine to promote recruitment and success of women, underrepresented minorities, and other disadvantaged groups.

PI_NAMEs: BHALLA, VIVEK  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Adult;Agreement;Area;Basic Science;Benign;Biological Sciences;Biomedical Research;Breathing;California;career;Childhood;Clinical Research;Clinical Sciences;cohort;Communities;Data;Dedications;Department chair;design;disadvantaged background;Disparity population;diversity and inclusion;Educational process of instructing;Educational workshop;Enrollment;experience;Fellowship;Functional disorder;Funding;Future;Goals;Grant;Health;high school;Individual;Infrastructure;innovation;Institution;Intellectual Interest;interest;investigator training;Kidney;Lead;Leadership;medical schools;Medicine;Mentors;Mentorship;Methods;Mission;National Institute of Diabetes and Digestive and Kidney Diseases;Nephrology;next generation;Outcome;Persons;Phase;Physicians;Physiology;Population Scientist Supplement (R25);Postdoctoral Fellow;pre-doctoral;programs;Publications;recruit;Research;Research Personnel;Research Technics;Research Training;Resources;Role;San Francisco;Scientist;Siblings;Structure;Students;success;summer internship;summer research;Talents;Teacher Professional Development;Techniques;Testing;Time;Training;Training Programs;Translational Research;undergraduate student;Underrepresented Minority;Underrepresented Populations;United States National Institutes of Health;Universities;Urology;Woman

PROJECT_TITLE: The Stanford Pre-Renal Initiative: Undergraduate Training in Kidney Health

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ADMINISTERING_IC: EY

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Rare Diseases

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative The purpose of the supplement is to acquire a replacement inverted microscope to enable the work proposed in the parent application, which is to test the hypothesis that mechanical forces directly drive tissue assembly in corneal stromal matrix produced by human corneal cells. The proposed work depends heavily on a TE2000E microscope that is 20 years old that performs a sophisticated battery of live-imaging measurements and single molecule tracking while tissue is being elaborated. Nikon is no longer supporting the microscope which is failing.

PI_NAMEs: RUBERTI, JEFFREY W (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 20 year old;Access to Information;Cell Culture Techniques;Cells;Collagen;Communication;Connective Tissue;Cornea;Couples;Development;Engineering;Environment;Equipment;Etiology;Extracellular Matrix;Eye;fibrillogenesis;Fibrosis;Genetic;Glaucoma;Growth;Homeostasis;Human;Image;improved;Keratoconus;Laser In Situ Keratomileusis;Measurement;mechanical force;Mechanics;Medicine;member;Mesenchymal;Microscope;Modeling;molecular assembly/self assembly;Morphogenesis;Myopia;Nature;Parents;Pathologic;Pathological Dilatation;Pattern;Phase;pressure;Recording of previous events;regenerative;Retinal Detachment;Sclera;Shapes;single molecule;Stress;Structure;Testing;Tissues;Traction;Tunic;Vertebrates;Vision;Weight-Bearing state;Work

PROJECT_TITLE: Mechanical Causation of Corneal Stromal Matrix Synthesis and Fibrosis


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurodegenerative;Neurosciences;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Newark

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE As we shift toward a new era of disease-modifying therapies, racial disparities in diagnosis and care of Alzheimer’s disease and related dementias (ADRD) will become even more evident and will likely increase unless we intervene in conditions driving such disparities in timely ADRD diagnosis. The proposed research validating timeliness measures and examining structural drivers of racial disparities in timely ADRD diagnosis will inform policies and interventions that focus on modifiable structural barriers to reduce disparities in timely ADRD diagnosis.

PI_NAMEs: KIM, MIN HEE  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: access disparities;accurate diagnosis;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease care;Alzheimer's disease related dementia;Area;Atlases;Attention;Automobile Driving;Black Populations;Black race;career;Caring;Characteristics;Classification;Clinical assessments;clinical diagnosis;cohort;Communities;Data;Dementia;density;deprivation;design;Diagnosis;Diagnostic;Disease;Disparity;Disparity in diagnosis;disparity reduction;Education;Ensure;Epidemiologic Methods;Epidemiology;ethnic disparity;Examinations and Diagnoses;Face;Family;Future;geographic disparity;Geography;Goals;Health;Health and Retirement Study;health care availability;Health Care Costs;health care disparity;Health care facility;Health Care Sector;health care service utilization;Health Services;Health Services Research;Healthcare;improved;Incidence;Individual;Infrastructure;innovation;Institution;Intervention;Knowledge;Link;Measurement;Measures;Medical;Medicare;Medicare claim;Mentorship;multidisciplinary;Natural History;Neighborhoods;Neurodegenerative Disorders;older adult;Pathway interactions;Patients;Pattern;Perception;Persons;Phase;Policies;Population;Prevention;Preventive care;Primary Care;Primary Health Care;Probability;Provider;public health intervention;Race;racial disparity;racial health disparity;Racial Segregation;Research;Research Personnel;residential segregation;Resources;Risk;Risk Factors;Sampling;segregation;social;social epidemiology;Social Work;Sociology;Stroke;structural determinants;Structural Racism;Surveys;survival prediction;time interval;Training;Transportation;trend;Validation

PROJECT_TITLE: Racial Disparities in Delayed Dementia Diagnosis: Structural Determinants and Validation of Timeliness Measures


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Ovarian Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Uterine Cancer;Women's Health Research

ORG_CITY: PHILADELPHIA

ORG_NAME: RESEARCH INST OF FOX CHASE CAN CTR

ORG_STATE: PA

PHR: PROJECT NARRATIVE Uterine serous carcinoma (USC) is the deadliest form of endometrial cancer due to frequent recurrence and metastasis with minimal treatment options. Black women are twice as likely to die from endometrial cancer than White women in the United States, however, the causes for this disparity are poorly understood, with emerging studies suggesting molecular alterations may be a contributing factor. The overall goal of this administrative supplement is to identify kinase inhibitor targets that can be used for the treatment of USC, as well as to evaluate the role of kinase signaling in the disparity of USC amongst Black and White women.

PI_NAMEs: DUNCAN, JAMES STUART (contact)

PROGRAM_OFFICER_NAME: O'HAYRE, MORGAN

PROJECT_TERMS: Ablation;Actins;Administrative Supplement;Ascites;Bioinformatics;Biometry;black women;cancer therapy;candidate identification;Carcinoma;Cell Line;cell motility;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cytoskeleton;Data Set;design;Disease;Disparity;Drug Targeting;Endometrial Carcinoma;Endometrium;Exhibits;Genetic;Goals;Greater sac of peritoneum;Growth;Human Resources;Impairment;Incidence;inhibitor;inhibitor therapy;insight;interest;Invaded;kinase inhibitor;Malignant Epithelial Cell;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Maps;Mass Spectrum Analysis;Measures;Metastatic/Recurrent;Methods;Modeling;Molecular;molecular targeted therapies;Monitor;Morbidity - disease rate;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;Organ;Ovarian Serous Adenocarcinoma;overexpression;Pathogenesis;Patients;Pharmaceutical Preparations;Phase;Phosphotransferases;Property;Protein Kinase;Proteins;Proteomics;racial disparity;Recurrence;Resistance development;Resources;response;Role;Serous;Signal Transduction;small hairpin RNA;small molecule;spheroids;targeted treatment;Technology;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;three dimensional cell culture;timeline;Tissues;Translating;tumor;United States;Uterus;White Women;Work

PROJECT_TITLE: Interrogating MRCK Protein Kinases in Ovarian Cancer


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Coronaviruses;Coronaviruses Vaccines;Emerging Infectious Diseases;Genetics;Human Genome;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW YORK

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative The Viral Immunity and Vaccination (VIVA) team studies how to best generate protective immune responses to vaccination against viruses such as but not limited to SARS CoV-2, influenza and dengue viruses. We leverage the team's extensive expertise in virology, immunology, genomics and data analysis with cutting edge technologies to achieve these goals.

PI_NAMEs: FERNANDEZ-SESMA, ANA  (contact);SIMON, VIVIANA A

PROGRAM_OFFICER_NAME: SINGLETON, KENTNER L

PROJECT_TERMS: 2019-nCoV;adaptive immune response;adaptive immunity;Administrative Supplement;Area;Argentina;biobank;Bioinformatics;Biological Assay;cell type;Cells;Cellular Indexing of Transcriptomes and Epitopes by Sequencing;Clinical;Clinical Trials;cohort;Communicable Diseases;Communities;Coronavirus;COVID-19 vaccination;COVID-19 vaccine;Cuba;Data;Data Analyses;data infrastructure;data mining;data repository;Data Set;data standards;Dengue Vaccine;Dengue Virus;Development;Differentiation Antigens;Early identification;Ensure;Enzyme-Linked Immunosorbent Assay;Epidemic;experience;experimental study;Exposure to;Flow Cytometry;Frequencies;Generations;Genes;Genomic approach;genomic data;Genomics;Goals;holistic approach;Hospitals;Human;human disease;Immune;Immune response;Immunity;Immunization Programs;Immunoglobulins;Immunologic Memory;immunological status;Immunology;Individual;Infection;Influenza vaccination;influenzavirus;Innate Immune Response;Innate Immune System;Investigation;live attenuated influenza vaccine;Maintenance;Measures;Mediating;Metadata;Methods;Modality;Modeling;mosquito-borne;multidisciplinary;network models;novel;Outcome;pandemic disease;pandemic potential;pathogen;Pathogenesis;Peripheral Blood Mononuclear Cell;Phenotype;phenotypic data;Physiological;Population;Population Characteristics;predictive modeling;Predisposition;programs;Qualifying;Research;Research Personnel;Respiratory Tract Infections;respiratory virus;response;RNA;Sampling;SARS coronavirus;seasonal influenza;sequencing platform;Serology;Serotyping;single-cell RNA sequencing;Standardization;success;System;Techniques;Technology;Tissues;Tonsil;tool;transcriptomics;Vaccinated;Vaccination;vaccination outcome;vaccine candidate;vaccine immunogenicity;vaccine response;vaccine trial;Vaccinee;Vaccines;vaccinology;Viral;Viral Antigens;Viral Pathogenesis;virology;Virus;Virus Diseases

PROJECT_TITLE: US-Cuba Administrative Supplement to the Viral Immunity and Vaccination (VIVA) Human Immunology Project Consortium


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Sleep Research

ORG_CITY: AMHERST

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

PHR: Project Narrative Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), may increase the expression of brain-derived neurotrophic factor. We propose to examine the benefits of NR supplementation upon sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor. Project Narrative

PI_NAMEs: WEISS, CARLEARA  (contact)

PROGRAM_OFFICER_NAME: MACKIEWICZ, MIROSLAW

PROJECT_TERMS: Academy;Activities of Daily Living;Adult;Age;aging population;Alzheimer's Disease;American;Amyloid beta-42;Animal Model;Applied Research;Award;Basic Science;Behavioral;Biochemistry;Biological;Biological Markers;Biometry;Brain-Derived Neurotrophic Factor;career development;Circadian Dysregulation;Circadian Rhythms;Clinical;clinical development;clinical training;Cognition;cognitive function;cognitive performance;Conduct Clinical Trials;Data;Dementia;Discipline of Nursing;diversity and inclusion;Elderly;Elements;empowerment;Enrollment;Environment;executive function;Exhibits;experience;Fellowship;Female;fitbit;Foundations;functional outcomes;Funding;Geriatric Assessment;Geriatrics;Geroscientist;Goals;Growth;healthy aging;Hippocampus;Human;human old age (65+);Impaired cognition;Impairment;improved;improvement on sleep;indexing;Individual;innovation;instrument;International;Intervention;intervention cost;Knowledge;Language;Leadership;Learning;male;Measurement;Measures;Medicine;Memory;Memory impairment;Mentors;mild cognitive impairment;Mitochondria;Molecular;Molecular Biology;monocyte;Niacinamide;Nicotinamide adenine dinucleotide;nicotinamide riboside supplementation;nicotinamide-beta-riboside;Nurses;old mice;older adult;Older Population;Parents;Participant;peripheral blood;Physical Performance;Pittsburgh Sleep Quality Index;placebo group;Placebos;poor sleep;potential biomarker;pre-clinical;prevent;programs;Psyche structure;Questionnaires;randomized, clinical trials;Research;Research Project Grants;Risk;Role;Science;Scientist;screening;Serum;Severities;Silver;skills;Sleep;Sleep disturbances;sleep quality;Sleeplessness;Societies;Supplementation;Synaptic plasticity;tau-1;Techniques;Testing;Training;Training Programs;Treatment Cost;Tsunami;Underrepresented Minority;Universities;Veterans;wearable device;Work

PROJECT_TITLE: The benefits of nicotinamide riboside upon cognition and sleep in older veterans


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Coronaviruses;Emerging Infectious Diseases;Immunization;Immunotherapy;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Vaccine Related

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: What Precursors Become Lung-Resident CD4 Memory that Protect Against Respiratory Infections or Cause Lung Pathology? Respiratory infections, which include the major SARS and influenza pandemics of the 21st century as well as yearly influenza outbreaks, are a leading cause of mortality and morbidity across the world. This grant will define the pathway of development of an immune T cell type known as CD4 TRM that become resident in the lung where they can rapidly protect against respiratory infections but may also cause lung damage, so we will explore their mechanisms of protection and damage. The results will give us new insights into how to develop vaccines that efficiently induce protection in the lung and treatments that minimize lung damage during an immune response to respiratory infection.

PI_NAMEs: DEVARAJAN, PRIYADHARSHINI  (contact)

PROGRAM_OFFICER_NAME: LIN, ADORA ASHELY

PROJECT_TERMS: 2019-nCoV;Acute respiratory infection;adaptive immune response;Automobile Driving;B-Lymphocytes;Bacterial Infections;Bordetella pertussis;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;cell type;Cells;Cessation of life;Circulation;Compensation;COVID-19;COVID-19 patient;Cytolysis;cytotoxic;cytotoxicity;Data;design;Deterioration;Development;Disease Outbreaks;Down-Regulation;Epithelial Cells;experimental study;fighting;Future;Gene Expression Profile;Generations;Genetic Transcription;Grant;helminth infection;Human;Immune;Immune response;Immunity;immunopathology;Immunotherapeutic agent;Immunotherapy;Infection;Inflammation;Influenza;influenza infection;influenza outbreak;insight;Interleukin-15;Interleukin-2;Knowledge;Learning;Location;Longevity;Lung;Lung immune response;lung injury;Maintenance;Mediating;Memory;Memory Loss;MHC Class I Genes;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutate;pandemic disease;pandemic influenza;pathogen;Pathogenicity;Pathologic;Pathology;Pathway interactions;Pattern;Phenotype;Play;Pneumococcal Pneumonia;Population;preservation;pressure;Prognosis;Proliferating;pulmonary function;Pulmonary Pathology;recruit;Respiratory distress;Respiratory physiology;Respiratory Tract Infections;respiratory virus;response;Risk;Role;SARS coronavirus;Severe Acute Respiratory Syndrome;Signal Transduction;Site;Structure of parenchyma of lung;T memory cell;T-Lymphocyte;therapy design;tissue resident memory T cell;Tissues;Tuberculosis;Vaccination;vaccine development;Vaccines;Viral;Viral Proteins;Virus Diseases

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: LEXINGTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE We know little of the pathway to brain health in African American men, mainly because there have been notably few brain imaging studies that included substantial numbers of older African American men. My proposed research will examine cognition and AD risk markers, test diagnostic accuracy, and characterize brain health in older, cognitively healthy, urban African American men. The results will provide insights toward identifying and validating markers of brain health and AD risk in African American men—a necessary step to understanding how AD affects men and which tailored interventions are most effective for mitigating AD.

PI_NAMEs: ESIAKA, DARLINGTINA  (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Affect;African American;African American population;Age;Aging;aging related;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Alzheimer's disease risk;Behavioral;Biological Markers;biomarker validation;Brain;brain health;Brain imaging;brain pathway;Brain region;caucasian American;Chronic Disease;Cognition;Cognitive;cognitive change;cognitive function;cognitive neuroscience;cognitive training;Communities;comorbidity;coping;Cross-Sectional Studies;Data;Dementia;Development;Diabetes Mellitus;Diagnosis;diagnostic accuracy;Diagnostic tests;Diet;Discrimination;Disease Progression;drinking;Early Diagnosis;Enrollment;Environmental Risk Factor;experience;Exposure to;Family;Functional Magnetic Resonance Imaging;Future;Genes;Genetic;Genetic Markers;Genomics;Health;health determinants;high risk;Hypertension;imaging biomarker;imaging study;Impaired cognition;improved;Individual;individual variation;insight;Intervention;Investigation;Knowledge;Life Style;lifestyle factors;Low income;Measures;medial temporal lobe;Mediating;Mediator;men;Mentors;mild cognitive impairment;Moderate Activity;Neighborhoods;neural;Neural Pathways;neuroimaging;Neurologic Symptoms;Neuropsychology;Observational Study;older adult;Pathway interactions;Patient Self-Report;Phase;Physical activity;pre-clinical;Prefrontal Cortex;prevent;racism;Reporting;Research;Risk Marker;Risk Reduction;risk variant;sleep quality;Smoking;social;social factors;Stress;Techniques;Testing;tool;Training;Trauma;urban dwelling;urban setting

PROJECT_TITLE: Early Characterization of Cognitive Status and AD Risk in African American Men


NIH_SPENDING_CATS: Clinical Research;Comparative Effectiveness Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Social Determinants of Health

PHR: PROJECT NARRATIVE As we prepare to scale cloud-first data science projects within DS-I Africa under the UZIMA-DS initiative, a U54 Research Hub funded by the NIH Data Science for Health Discovery and Innovation in Africa Initiative, we propose developing good practices for building efficient and responsible data pipelines for research. These practices will enable leveraging cloud infrastructure on limited budgets while being mindful of our carbon footprint. Using data pipelines from the ongoing UZIMA-DS project, which processes daily Fitbit data from 500 healthcare workers on a Microsoft Azure instance, we will build and evaluate data pipelines using three tools and approaches within the Azure environment. We will measure processing time, costs, and carbon emissions. Our ultimate goal is to achieve “Efficient Data, Sustainable Future for Research” by developing a set of good practices that research teams can use to ensure maximum resource efficiency while minimizing environmental impact.

PROJECT_TERMS: Address;Administrative Supplement;Adopted;Africa;Artificial Intelligence;Benchmarking;Budgets;Carbon;carbon emissions;Child Health;climate science;cloud based;Cloud Computing;Cloud Service;Collaborations;computerized data processing;computing resources;cost;cost effective;Cost efficiency;cost efficient;Cost Savings;Coupled;Data;data exchange;data management;data pipeline;Data Science;data sharing;Data Storage and Retrieval;empowerment;energy efficiency;Ensure;Environment;Environmental Impact;Expenditure;fitbit;Foundations;Frequencies;Funding;Future;Goals;Health;Health Personnel;Health Sciences;High Performance Computing;improved;Infrastructure;innovation;large datasets;low and middle-income countries;machine learning method;Maternal Health;Measures;Mental Health;Methodology;Michigan;mindfulness;Movement;neonatal health;novel;Operations Research;Outcome;parent project;Positioning Attribute;Process;Research;research in practice;Research Project Grants;Resources;Savings;skills;Techniques;Testing;Time;tool;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Sustainable Cloud Operations for Research and Environmental Impact (SCORE - EI)


NIH_SPENDING_CATS: Breast Cancer;Cancer;Estrogen;Women's Health Research

ORG_CITY: MILWAUKEE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: Project Narrative: The proposed research is relevant to public health because it focuses on the rational development of a therapeutic strategy targeting clinically occult breast cancer cells that persist despite current treatments. Once such a strategy has been developed, there is the potential for significant improvement in anti- cancer therapy to prevent tumor recurrence and disease progression. Thus, the proposed research is relevant to the mission of NCI through the development of improved treatments that would decrease morbidity and mortality in patients with breast cancer.

PI_NAMEs: MILLER, TODD W. (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: adjuvant endocrine therapy;anti-cancer treatment;Antineoplastic Agents;Aromatase Inhibitors;biological adaptation to stress;Blood;Bone Marrow;Breast Cancer Cell;Breast Cancer Patient;cancer cell;cancer recurrence;cancer therapy;cancer type;Catabolism;Cell Line;Cell Survival;Clinical;Clinical Trials;Data;Dependence;deprivation;Development;Disease;Disease Progression;drug development;Drug resistance;drug resistance development;Drug Tolerance;Endocrine;ERBB2 gene;ESR1 gene;Estrogens;Excision;Exhibits;experience;fatty acid metabolism;Fatty Acids;Future;Goals;hormone therapy;Human;improved;In Vitro;in vivo;inhibitor;innovation;insight;Investigation;lipid metabolism;Maintenance;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Metabolic;Metabolism;Mission;Mitochondria;Morbidity - disease rate;mortality;Neoplasm Metastasis;Operative Surgical Procedures;Outcome;oxidation;Oxidative Phosphorylation;Oxidative Stress;patient derived xenograft model;Patients;pharmacologic;Pharmacotherapy;Phase;Pre-Clinical Model;preservation;prevent;Production;Prognosis;Public Health;Recurrence;Recurrent disease;Recurrent tumor;Research;Resistance;Respiration;Role;Signal Transduction;Testing;Therapeutic;therapeutic development;Therapeutically Targetable;therapy development;Time;Tissue Model;treatment strategy;tumor;Tumor Tissue;Woman

PROJECT_TITLE: Therapeutically leveraging metabolic vulnerabilities in breast cancer

STUDY_SECTION: DT

STUDY_SECTION_NAME: Developmental Therapeutics Study Section[DT]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Hematology

ORG_CITY: DENTON

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NORTH TEXAS

PHR: PROJECT NARRATIVE Platelets play crucial roles in the body, however, the mechanisms and molecular regulators of platelet regulation are poorly understood, including the role of the extracellular matrix and glycosaminoglycans (GAGs). The proposed research aims at elucidating the role that GAGs play in thrombopoiesis, including the identification of GAG targets that can be harnessed for therapeutic gain. This research proposal is relevant to public health and the NHLBI’s mission as it aims to advance the development of therapeutic agents for thrombocytopenic conditions.

PI_NAMEs: AFOSAH, DANIEL KWAME (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Advanced Development;Advisory Committees;Affinity;analog;analytical ultracentrifugation;Binding;Binding Proteins;Biological;Biological Assay;Biology;biomacromolecule;biophysical analysis;biophysical techniques;Biopolymers;Blood;Blood Circulation;Blood Platelets;Bone Marrow;career;Career Choice;career development;Charge;chemical property;Chemicals;Coagulation Process;Complex;computer studies;Coupled;Crystallography;Cytoplasm;Data;Development;Development Plans;Dimerization;Disease;Drug Targeting;Ensure;Environment;Excision;experience;Extracellular Matrix;Flavonoids;Foundations;functional mimics;Funding;Generations;Glycosaminoglycans;Hematopoietic stem cells;Heparitin Sulfate;high throughput screening;Human;In Vitro;in vivo;Inflammation;innovation;ITIM;Length;Letters;Libraries;Malignant Neoplasms;Megakaryocytes;Megakaryocytopoieses;member;Mentored Clinical Scientist Development Program;Mentors;Mentorship;mimetics;Mission;Molecular;molecular modeling;Mus;National Heart, Lung, and Blood Institute;Nature;novel;Organic Synthesis;Outcome;Pattern;Pharmaceutical Preparations;Photoaffinity Labels;Plasma;Platelet Count measurement;Play;Postdoctoral Fellow;Preparation;prevent;Process;Production;promoter;Proteins;Proteomics;Public Health;receptor;Records;Regulation;Research;Research Personnel;Research Proposals;Research Training;Resources;Role;scaffold;screening;Signal Transduction;skills;small molecule;small molecule libraries;stem;Stream;Structure;Structure-Activity Relationship;sugar;Sulfate;Surface Plasmon Resonance;Therapeutic;Therapeutic Agents;therapeutic development;three dimensional structure;Thrombocytopenia;Thrombopoiesis;Thrombosis;United States National Institutes of Health;Validation;X-Ray Crystallography

PROJECT_TITLE: Synthetic glycosaminoglycan mimetics as regulators of megakaryopoiesis and thrombopoiesis


NIH_SPENDING_CATS: Bioengineering;Health Effects of Indoor Air Pollution

ORG_CITY: DETROIT

ORG_NAME: WAYNE STATE UNIVERSITY

PHR: PROJECT NARRATIVE When inhaled at high concentrations, carbon monoxide causes cardiac and neurocognitive deficits and death; however, when produced at low concentrations in tissue, carbon monoxide acts as an intracellular signal and has even been tested as a therapeutic agent. In this proposal, we aim to develop a microbial carbon monoxide sensor, RcoM, into (1) a fast-acting carbon monoxide scavenger that can serve as an antidote for carbon monoxide poisoning and (2) a sensitive detector of carbon monoxide in living cells. Development of these molecular therapeutics and tools will dramatically improve the current standard of care for carbon monoxide poisoning and advance our understanding of intracellular carbon monoxide signaling and toxicology, with the potential to substantially decrease death and disability caused by this common poisoning.

PI_NAMEs: DENT, MATTHEW RYAN (contact)

PROGRAM_OFFICER_NAME: GILLASPY, ALLISON

PROJECT_TERMS: Acute;Address;Affinity;Amino Acids;Antidotes;Binding;Biological;biophysical chemistry;Biosensor;Calibration;Carbon Monoxide;Carbon Monoxide Poisoning;Cardiac;career;cell growth;Cells;Cessation of life;chemical stability;Chemicals;circadian regulation;Clinical;Clinical Research;conventional therapy;CRISPR/Cas technology;Cytoprotection;design;Detection;detector;Development;Diagnosis;disability;Disease;Emergency department visit;Erythrocytes;Exhibits;experience;Fluorescence;Functional disorder;Health;Heme;Hemeproteins;hemodynamics;Hemoglobin;Human;improved;In Vitro;in vivo;induced pluripotent stem cell derived cardiomyocytes;Infection;Inflammation;Inhalation;innovation;Inorganic Chemistry;insight;Intravenous;Intravenous infusion procedures;Ischemia;Kinetics;Learning;Ligands;long-term sequelae;Mammalian Cell;Mentorship;Metabolism;Methods;microbial;Modeling;Molecular;Molecular Target;Morbidity - disease rate;mortality;mouse genome;mouse model;Mus;Neurocognitive;Neurocognitive Deficit;Organ;organ injury;organ transplant rejection;Organism;Outcome;Oxygen;Patient-Focused Outcomes;Patients;Pattern;Persons;Physiological;point of care;Poisoning;pre-clinical;preclinical study;pressure;prevent;Production;Proliferating;Property;Recombinants;Reperfusion Injury;Reporter;Reporter Genes;Research Personnel;response;Role;Safety;safety assessment;scaffold;sensor;Signal Pathway;Signal Transduction;Signaling Molecule;skills;Spectrophotometry;standard of care;Survivors;Testing;Therapeutic;Therapeutic Agents;Tissues;tool;Toxic effect;Toxicology;transcription factor;Transfection;Transgenic Organisms;United States;Variant

PROJECT_TITLE: Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cells


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: PROJECT NARRATIVE Sympathetic nervous system activity is increasingly appreciated as a major contributor to pulmonary hypertension severity and prognosis. Our studies focus on neuronal-immune cell interactions that seek to uncover the mechanism involved in disease-associated sympathetic activity. We focus in part on a subset of TREM2 expressing disease-associated microglia as a therapeutic target for the treatment of pulmonary hypertension and its associated end-organ damage.

PI_NAMEs: OLIVEIRA, ALINE CRISTINA (contact)

PROGRAM_OFFICER_NAME: SUTLIFF, ROY L

PROJECT_TERMS: Ablation;Animal Model;Area;Arrhythmia;Attenuated;attenuation;Brain;Brain region;Cardiopulmonary;Cardiovascular Diseases;Cardiovascular system;Cell Communication;Cells;Central Nervous System;Cessation of life;Chronic;Data;Death Rate;Development;Disease;Disease associated microglia;drug development;Dysautonomias;Epigenetic Process;Etiology;Evaluation;experience;Experimental Models;experimental study;Exposure to;Flow Cytometry;Functional disorder;Gene Expression;gene function;Genetic Models;Genetic Techniques;Goals;Heart;Hematopoietic;Hematopoietic stem cells;Hypothalamic structure;hypoxia-induced pulmonary hypertension;Immune;Immunohistochemistry;improved;Induced Neurons;Infiltration;Inflammatory;innovation;insight;Knockout Mice;Lung;member;Mentors;Mentorship;Methodology;Microglia;Mus;Myelogenous;Myeloid Cells;Neuroanatomy;Neuroimmune;neuroinflammation;Neuronal Plasticity;Neurons;neurotransmission;novel;Nucleus solitarius;Organ;Outcome;Output;paraventricular nucleus;Pathogenicity;Patients;Pharmacotherapy;Phase;Phenotype;Predisposing Factor;professor;Prognosis;programs;Progressive Disease;Publishing;Pulmonary Hypertension;Research;respiratory;right ventricular failure;Scientist;Series;Severities;single-cell RNA sequencing;Slice;Sympathetic Nervous System;systemic inflammatory response;targeted treatment;Techniques;Testing;Therapeutic;therapeutic target;therapy development;Training;TREM2 gene;two photon microscopy;Up-Regulation;vasoconstriction;Ventricular Dysfunction

PROJECT_TITLE: Neuroimmune axis contribution to the pathophysiology of pulmonary hypertension


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: Boston

ORG_NAME: EIP PHARMA, INC.

PHR: Dementia with Lewy bodies (DLB), the second most common cause of neurodegenerative dementia after Alzheimer’s disease (AD), is rapidly progressive with a median time from diagnosis to death or nursing home half that seen with AD and extensive burden on both patients and family caregivers. There are no approved treatments, though some drugs approved for other diseases may partially or temporarily relieve some of its cognitive and motor symptoms. The proposed research would advance clinical testing of neflamapimod as a treatment to not only relieve symptoms but also treat the underlying disease process, potentially providing hope for DLB sufferers and their families.

PI_NAMEs: ALAM, JOHN  (contact);GALVIN, JAMES E

PROGRAM_OFFICER_NAME: RYAN, LAURIE M

PROJECT_TERMS: Admission activity;Adverse event;Affect;Aggressive behavior;Agitation;Alzheimer's Disease;American;Attention;basal forebrain;basal forebrain cholinergic neurons;Basal Nucleus of Meynert;Behavioral Symptoms;Biological Availability;Biological Markers;Cessation of life;cholinergic;Cholinesterase Inhibitors;Clinical;Clinical dementia rating scale;clinical development;clinical efficacy;Clinical Research;Clinical Trials;clinically relevant;Cognition;Cognitive;Collection;cooperative study;Data;Dementia;Dementia with Lewy Bodies;Diagnosis;Disease;Dose;Double-Blind Method;Down's Syndrome;Drug usage;Effectiveness;efficacy evaluation;Electroencephalography;Enrollment;Enzymes;Equipment and supply inventories;executive function;Eye;Family;family burden;Family Caregiver;Functional disorder;Functional Magnetic Resonance Imaging;Funding;gray matter;Grief reaction;Hallucinations;impression;improved;inhibitor;inhibitor therapy;investigator-initiated trial;kinase inhibitor;Laboratories;Magnetic Resonance Imaging;Measures;Medical;Mental Depression;Mental disorders;Monitor;Motor;motor symptom;Movement Disorder Society Unified Parkinson's Disease Rating Scale;Mus;Nerve Degeneration;Neurobehavioral Manifestations;neurodegenerative dementia;neuropsychiatry;Neuropsychological Tests;Nursing Homes;off-label use;Oral;Outcome;Outcome Measure;p38 Mitogen Activated Protein Kinase;Parkinson Disease;Pathogenicity;patient population;Patients;Pharmaceutical Preparations;Pharmacodynamics;Phase;phase 2 study;phase III trial;Placebo Control;pre-clinical;preclinical study;primary endpoint;Process;prospective;Publications;Quality of life;Randomized;reduce symptoms;Research;research clinical testing;response;Rest;Safety;secondary endpoint;Sleep;Sum;System;Testing;Therapeutic;therapeutic target;Time;Transgenic Organisms;treatment effect;visual learning

PROJECT_TITLE: A Phase 2b Clinical Study of the P38 Alpha Kinase Inhibitor Neflamapimod in Patients with Mild-to-Moderate Dementia with Lewy Bodies (DLB)


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Nutrition

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Heart failure with preserved ejection fraction (HFpEF) accounts for roughly half the cases of heart failure in the United States. HFpEF is a complex syndrome that presents with diastolic dysfunction, and is associated with comorbidities like obesity, hypertension, diabetes and metabolic syndrome. The underlying pathophysiology of HFpEF is not well understood, all clinical trials in HFpEF have failed to show any benefit on clinical parameters thus far. Understanding the role of inflammation on the onset and progression of HFpEF pathophysiology will significantly improve our knowledge and potentially identify novel therapeutic targets.

PI_NAMEs: NATARAJAN, NIRANJANA  (contact)

PROGRAM_OFFICER_NAME: POIZAT, CORALIE ISABELLE

PROJECT_TERMS: age related;Animal Model;arm;base;Biological Markers;Biology;Blood Vessels;C3AR1 gene;Cardiac;Cardiology;Cardiovascular Diseases;Cardiovascular system;career;career development;Cells;chemokine;Clinical;Clinical Research;Clinical Trials;cobra venom factor;Collaborations;Committee Members;comorbidity;comparison control;Complement;Complement 3;Complement 3a;Complement Activation;complement pathway;complement system;Complex;confocal imaging;coronary fibrosis;cytokine;Data;Development Plans;Diabetes Mellitus;Dichloromethylene Diphosphonate;dietary;Disease;EFRAC;Environment;Enzyme-Linked Immunosorbent Assay;Epidemic;evidence base;Exhibits;experimental study;Extracellular Matrix;Fellowship;Fibroblasts;Fibrosis;Flow Cytometry;Four-Dimensional Echocardiography;frontier;Functional disorder;Gene Expression;Genes;Glucose Intolerance;Goals;Grant;Heart;Heart failure;High Fat Diet;Histology;Hypertension;IL6 gene;Immune;Immunology;improved;In Vitro;Infiltration;Inflammasome;Inflammation;Inflammatory;Inflammatory Response;Institute of Medicine (U.S.);Investigation;Knowledge;Laboratories;Left Ventricular Ejection Fraction;Left Ventricular Remodeling;Left ventricular structure;Liposomes;Macrophage;Measures;Mediating;Mentors;Mentorship;Metabolic syndrome;Modeling;Molecular;Mus;Myocardial Infarction;Myofibroblast;Natural Immunity;new therapeutic target;novel;Obesity;Pathologic;Pathology;Pathway interactions;Patients;Phase;Phenotype;Physiology;Pilot Projects;Plasma;Play;Population;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;preservation;Proliferating;Rattus;receptor;Regulation;Relaxation;Research;Research Activity;Research Personnel;Resolution;Resources;Role;Sampling;Signal Transduction;Stress;Symptoms;Syndrome;systemic inflammatory response;Systems Biology;Testing;therapeutic target;Time;Training;transcriptomics;United States;Universities;Up-Regulation;vascular endothelial dysfunction;Ventricular;Western Blotting;Work;Writing

PROJECT_TITLE: Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction


NIH_SPENDING_CATS: Hematology;Rare Diseases;Sickle Cell Disease

ORG_CITY: SEATTLE

ORG_NAME: BLOODWORKS

ORG_STATE: WA

PHR: Project Narrative Vaso-occlusive events remain a clinical burden in sickle cell disease and is the major cause of organ failure. Although a major contributor to vaso-occlusion in this disease is redox stress, the mechanism by which redox stress promotes vaso-occlusion is not well understood. The goal of this project is to determine the role of oxidative cysteine electron transferring events in vaso-occlusion that are driven by thiol isomerases, which would reveal redox targetable mechanisms to prevent vaso-occlusion in sickle cell disease.

PI_NAMEs: YANG, MOUA  (contact)

PROJECT_TERMS: Adhesions;Antioxidants;Biological Assay;Biology;Blood Platelets;Carbon;Cell Adhesion;Cell-Cell Adhesion;Cells;Characteristics;Chemicals;Clinical;Clinical Research;Complement;Cysteine;Data;Disease;disease model;Disulfides;Electron Transport;Electrons;Endothelial Cells;Environment;Event;extracellular;Fetal Hemoglobin;Flavonoids;Glutamine;Goals;Hemoglobin;Hemoglobin concentration result;Hemorrhage;Hemostatic function;hydroxyurea;imaging system;improved;in vivo;Injury;intravital microscopy;Isomerase;isoquercetin;K-Series Research Career Programs;Lasers;Leukocytes;Mediating;Methods;Modeling;Modification;Monitor;mouse model;Mus;neutrophil;Neutrophil Activation;novel therapeutic intervention;Organ failure;oxidant stress;Oxidation-Reduction;Oxidative Stress;Oxidoreductase;P-Selectin;Patients;Phase;Platelet Activation;Positioning Attribute;prevent;programs;Protein Disulfide Isomerase;Recurrence;Research;Risk;Role;Sickle Cell;Sickle Cell Anemia;skills;Stress;Sulfhydryl Compounds;Sulfur;Techniques;Testing;thromboinflammation;Thrombosis;thrombotic;Thrombus;Training;vaso-occlusive crisis;Withdrawal

PROJECT_TITLE: Oxidative Cysteine Modification by Thiol Isomerases in Sickle Cell Disease


NIH_SPENDING_CATS: Biotechnology;Cardiovascular;Genetics;Heart Disease;Orphan Drug;Precision Medicine;Rare Diseases

ORG_CITY: LA JOLLA

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: NARRATIVE  Mutations in many genes place patients at very high risk of developing dilated cardiomyopathy (DCM), which often leads to heart failure and early death. Personalized mutation-specific therapies have shown great promise in other areas, but none are available for DCM. I will test the hypothesis that identifying the molecular pathways by which different mutations lead to DCM may facilitate the development of targeted therapeutic strategies.

PI_NAMEs: BRIGANTI, FRANCESCA  (contact)

PROJECT_TERMS: Address;Age;Area;BACH1 gene;Basic Science;Biological;Candidate Disease Gene;Cardiac;cardiac tissue engineering;career;causal variant;Cause of Death;Cessation of life;Clinical;Communities;Compensation;Complement;Correlation Studies;design;Development;Dilated Cardiomyopathy;Disease;disease model;disease phenotype;disease-causing mutation;drug development;Drug Screening;Etiology;Foundations;functional genomics;Functional Imaging;Future;Gene Expression Regulation;Genes;Genetic;Genome;Genotype;genotyped patients;Goals;Health;Heart failure;high risk;high throughput screening;Hospitalization;human disease;human tissue;improved;In Vitro;in vitro Model;in vivo Model;induced pluripotent stem cell derived cardiomyocytes;insight;Intervention;Knock-in Mouse;Knockout Mice;Knowledge;Lead;Legal patent;life span;Link;metabolome;microbiome;MicroRNAs;Modeling;Molecular;Molecular Target;molecular targeted therapies;mouse model;mutant;Mutation;new therapeutic target;novel strategies;novel therapeutic intervention;novel therapeutics;Onset of illness;Outcome;overexpression;Pathogenicity;Pathway interactions;Patients;personalized therapeutic;Persons;Phenotype;Physiological;Physiology;Post-Transcriptional Regulation;precision medicine;prevent;Proteins;prototype;Publishing;Research;Research Personnel;skills;Stream;symptom management;Symptoms;System;targeted treatment;Testing;Therapeutic;Therapeutic Effect;therapeutic evaluation;therapeutic miRNA;therapeutic target;tool;transcriptome;Translating;United States;Variant;Work

PROJECT_TITLE: Using miRNA to identify new therapeutic pathways for dilated cardiomyopathy


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: PROJECT NARRATIVE Sexual minorities are at heightened risk of alcohol misuse; however, existing research is largely based on a static and unidimensional construct of sexual orientation rather than a fluid and multidimensional construct of sexual orientation. This longitudinal population-based study will examine the fluidity and multidimensionality of sexual orientation, improve longitudinal estimates of alcohol misuse and its negative health consequences, and identify modifiable risk and protective factors in multiple domains (individual-, social- and policy-level). This study will provide new information to improve assessment, prevention, screening, and intervention efforts targeted towards reducing alcohol-related consequences among sexual minorities.

PI_NAMEs: EVANS-POLCE, REBECCA J. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Address;Adolescent;Adult;Age;alcohol measurement;alcohol misuse;alcohol related consequences;alcohol risk;alcohol use disorder;Alcohols;Behavior;Cannabis;Complement;cost;COVID-19;Criminal Justice;Data;Dimensions;Discrimination;Distal;Engineering;ethnic identity;fluidity;Gender Identity;gender minority group;gender minority health disparity;Goals;Health;health data;Healthcare;Heterogeneity;Heterosexuals;improved;Individual;interest;Intervention;Laws;Lesbian Gay Bisexual;Liquid substance;longitudinal design;Longitudinal Studies;Measures;Medicine;Modeling;modifiable risk;Movement;neglect;Outcome;Patient Self-Report;Pharmaceutical Preparations;physical conditioning;Policies;polysubstance use;Population Assessment of Tobacco and Health;population based;Population Study;Prevention;Productivity;protective factors;Public Policy;public policy on alcohol;racial identity;Reporting;Research;Research Design;response;Risk;Risk Factors;Sampling;screening;secondary analysis;Severities;Sex Orientation;Sexual and Gender Minorities;sexual identity;sexual minority;sexual minority group;sexual minority health;sexual minority women;Shapes;social;Social Concepts;Social Interaction;stressor;Subgroup;Substance Use Disorder;Symptoms;Time;Tobacco;United States National Academy of Sciences;Variant;Work;Youth

PROJECT_TITLE: Sexual Fluidity and Longitudinal Changes in Alcohol Misuse and Associated Health Consequences

STUDY_SECTION: SSPB

STUDY_SECTION_NAME: Social Sciences and Population Studies B Study Section[SSPB]


NIH_SPENDING_CATS: Biotechnology;Genetics;HIV/AIDS;Human Genome;Immunization;Immunotherapy;Infectious Diseases;Prevention;Vaccine Related

ORG_CITY: DAVIS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: This project will examine how an HIV-infected person’s metabolism can affect their immune response to a therapeutic vaccine. We seek to develop techniques for altering metabolism either systemically or locally, at the site of therapeutic-vaccine administration, to make responses better. If successful then this project will explain why some individuals respond well to therapeutic vaccines and others do not.

PI_NAMEs: HARTIGAN-O'CONNOR, DENNIS J. (contact)

PROGRAM_OFFICER_NAME: SMILEY, STEPHEN T

PROJECT_TERMS: 2019-nCoV;Affect;Aftercare;Amino Acids;arginase;Arginine;Catabolism;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Physiology;Cells;Cellular Metabolic Process;Clinical Trials;Cohort Studies;Data;design;detection of nutrient;Energy-Generating Resources;Enzymes;exhaust;experimental study;Failure;FRAP1 gene;Generations;HIV;Human;human data;Immune response;Individual;Infection;inhibitor;Interruption;Intervention;Jaw;Link;Literature;Macaca;Macaca mulatta;Measures;Mediating;Memory;Metabolic;Metabolic Control;Metabolic Pathway;metabolic profile;Metabolism;metabolomics;mTOR inhibition;multiple omics;nonhuman primate;Nucleocapsid;Nutrient;Pathway interactions;Pattern;Persons;Plasma;Population;Positioning Attribute;pre-clinical;Property;recruit;Regimen;Regulation;response;restraint;Route;Sampling;sensor;Sirolimus;Site;SIV;SIV Vaccines;stem;success;System;T cell differentiation;T cell response;T cell therapy;T memory cell;T-Cell Development;T-Lymphocyte;T-Lymphocyte Subsets;Techniques;Testing;Therapeutic;therapeutic vaccine;transcriptome sequencing;Vaccinated;Vaccination;Vaccine Therapy;vaccine trial;Vaccinee;Vaccines;Variant;vector vaccine;Viremia;Virus;Virus Replication

PROJECT_TITLE: Project 2


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Social Determinants of Health

PHR: PROJECT NARRATIVE Physical activity helps to prevent weight gain and preserves cardiovascular health yet many young adults do not meet federal guidelines for aerobic physical activity and gain weight. Smartphones and wearable activity trackers create new possibilities for promoting young adults’ physical activity and preventing weight gain. This project evaluates the efficacy of Precision AIM, a digital intervention that makes person-specific, context- sensitive dosing decisions to ensure each person receives the right message content for them at the right time.

PI_NAMEs: CONROY, DAVID E. (contact);LAGOA, CONSTANTINO MANUEL

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Accelerometer;adaptive intervention;Adult;Aerobic;Age;Algorithmic Analysis;arm;Behavior;Behavior Therapy;Biological;Body Weight decreased;cardiometabolism;Cardiovascular Diseases;cardiovascular health;cardiovascular risk factor;Cellular Phone;Characteristics;clinical research site;Clinical Trials;Computational algorithm;Computer Models;cost;Data;Data Science;design;Development;Devices;digital data;digital intervention;Dose;Education;effective intervention;efficacy evaluation;efficacy testing;Employment Status;Engineering;Ensure;Environment;Expert Opinion;food insecurity;frontier;Guidelines;Health;Heterogeneity;indexing;Individual;innovation;Intervention;intervention effect;Learning;Libraries;Link;Location;Maintenance;Measures;Meta-Analysis;meteorological data;Methods;mobile computing;Modeling;Monitor;National Heart, Lung, and Blood Institute;novel;novel strategies;Participant;participant retention;Persons;Physical activity;Precipitation;preference;preservation;prevent;Prevention strategy;primary outcome;Primary Prevention;Protocols documentation;Randomized;Randomized, Controlled Trials;rapid weight gain;recruit;Research;response;Series;sex;simulation;social;Social Characteristics;System;systematic review;Technology;Temperature;Text Messaging;Time;tool;treatment effect;treatment response;Update;Vision;wearable data;wearable device;Weather;Weight;Weight Gain;weight gain prevention;Weight maintenance regimen;Work;young adult

PROJECT_TITLE: Efficacy of Precision Text Messaging to Increase Physical Activity in Insufficiently-Active Young Adults

STUDY_SECTION: SSPT

STUDY_SECTION_NAME: NHLBI Single-Site and Pilot Clinical Trials Study Section[SSPT(MA)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Drug Abuse (NIDA only);Infectious Diseases;Patient Safety;Substance Misuse

ORG_CITY: CORAL GABLES

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Narrative The research infrastructure of the Florida Node Alliance supports the development and implementation of innovative clinical trials to answer a broad spectrum of translational substance abuse treatment research questions across a wide variety of treatment settings and diverse patient populations. CTN 0121: Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders (SUD) among Hospitalized Patients, aims to reduce hospital readmissions for patients with these conditions.

PI_NAMEs: FEASTER, DANIEL J;SZAPOCZNIK, JOSE  (contact)

PROGRAM_OFFICER_NAME: DOBBINS, RONALD

PROJECT_TERMS: Adolescent;Adult;Ambulatory Care;Antibiotics;Caring;Clinical;Clinical Treatment;Clinical Trials;Clinical Trials Network;Collaborations;Communicable Diseases;comorbidity;design;Development;Dissemination and Implementation;Drug abuse;effectiveness evaluation;effectiveness testing;Florida;follow-up;Frequencies;Funding;group intervention;Harm Reduction;Health;health care settings;health economics;Healthcare;HIV;HIV/HCV;hospital readmission;Hospitalization;Hospitals;improved;Infection;Infrastructure;injection drug use;Injections;innovation;integrated care;Intervention;Leadership;Mainstreaming;Mental Health;Modeling;mortality;Participant;patient population;Patient Readmission;Patient-Focused Outcomes;Patients;Population;Provider;Randomized;Randomized, Controlled Trials;Recovery;Research Infrastructure;Running;Services;Severities;substance abuse treatment;substance use;Substance Use Disorder;success;Testing;Time;translational pipeline;treatment as usual;treatment research

PROJECT_TITLE: The Florida Node Alliance of the National Drug Abuse Treatment Clinical Trials Network


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Brain Disorders;Neurosciences

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: Narrative  M-channels play a critical role for preventing neuronal excitability disease such as seizures. The details are unclear regarding how M channel activity is regulated. The proposed study aims to provide a detailed description of how M channels are regulated, which is expected improve therapies for excitability diseases.

PI_NAMEs: ARCHER, CRYSTAL RAE (contact)

PROGRAM_OFFICER_NAME: STOKES, KALYNDA K

PROJECT_TERMS: 3-Dimensional;Affect;Affinity;alpha helix;Award;Binding;Binding Sites;Biological Assay;biophysical techniques;Ca(2+)-Calmodulin Dependent Protein Kinase;Calmodulin;career;Career Mobility;Cell Culture Techniques;cofactor;Cryoelectron Microscopy;Data;Disease;Electrophysiology (science);Encephalopathies;Environment;Epilepsy;Event;Financial Support;Foundations;Functional disorder;Future;G-Protein-Coupled Receptors;GTP-Binding Proteins;Health;Human;improved;innovation;Interdisciplinary Study;Ion Channel;Isotope Labeling;Maps;Molecular;Muscarinic M1 Receptor;mutant;Mutation;Neonatal;neuronal excitability;novel;optogenetics;Pain;Pharmacology;Phase;Phosphatidylinositol 4,5-Diphosphate;Phosphatidylinositols;Phosphorylation;Physiology;Play;prevent;programs;Protein Isoforms;Protein Kinase;Protein Kinase C;Regulation;Reporting;Research;Resources;Role;Seizures;Serine;Signal Transduction;Signaling Molecule;Site;stoichiometry;Stroke;structural biology;Structure;supportive environment;Techniques;Testing;Training;Traumatic Brain Injury;X-Ray Crystallography;Xenopus

PROJECT_TITLE: Structural consequences of PKC-dependent phosphorylation of Kv7.2


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Clinical Research;Data Science;HIV/AIDS;Networking and Information Technology R&D (NITRD)

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative This project will make MWCCS data more discoverable and interoperable, with the ultimate goal of promoting MWCCS data use and sharing. The proposal focuses on metadata and summary ﬁle data.

PI_NAMEs: D'SOUZA, GYPSYAMBER ;GANGE, STEPHEN J (contact);GOLUB, ELIZABETH T

PROGRAM_OFFICER_NAME: PATHAK, ELIZABETH BARNETT

PROJECT_TERMS: Adult;Algorithms;application programming interface;Behavioral;Characteristics;Clinical;Cohort Studies;comorbidity;dashboard;Data;Data Analyses;data dashboard;data dictionary;data ecosystem;data exploration;Data Files;data hosting;Data Security;Documentation;Environment;federated learning;Future;Gender;Genomics;Goals;HIV;In Situ;interoperability;Longitudinal cohort study;metabolomics;Metadata;Mission;multidimensional data;National Institute of Allergy and Infectious Disease;Participant;Peer Review;Persons;Privacy;public database;Publications;repository;Research Personnel;Security;Series;social;Standardization;Technology;Visit

PROJECT_TITLE: MWCCS NIAID Data Ecosystem Supplement


NIH_SPENDING_CATS: Autoimmune Disease;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lupus;Prevention

ORG_CITY: WORCESTER

ORG_DEPT: DERMATOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: NARRATIVE Autoimmune diseases affect up to 8% of the US population and its prevalence is rising, setting the stage for an impending public health crisis that we do not yet understand and are not prepared to face. We will leverage a multidisciplinary team of leading investigators, cutting edge tools designed for at-home, longitudinal tissue sampling, and an innovative strategy to discover how autoimmunity begins, relapses, and spreads in a large population of at-risk individuals. This approach will provide insight into autoimmunity that will help physicians better manage, or even prevent, devastating consequences of these diseases in the future.

PI_NAMEs: GARBER, MANUEL ;HARRIS, JOHN E (contact);IRVINE, DARRELL J;RASHIGHI, MEHDI

PROGRAM_OFFICER_NAME: GUERAU, MIREIA

PROJECT_TERMS: Affect;Age of Onset;Autoantibodies;Autoimmune Diseases;Autoimmunity;Biological Markers;biomarker identification;Blood;Blood capillaries;Cells;Clinical;clinical diagnosis;Clinical Management;cohort;Collection;Cutaneous Lupus Erythematosus;Data;Dermatologist;design;Development;Devices;Diagnosis;Disease;Disease Marker;Disease Progression;Disproportionately impacts women;Engineering;Enrollment;Epithelial Cells;Exhibits;Face;Family member;Future;Gene Expression;Genetic;Genotype;Hazard Models;health disparity;High Prevalence;Home;Human;Immune;Individual;innovation;insight;Interferon Type I;interstitial;Liquid substance;Longitudinal cohort;Lupus;Methods;minimally invasive;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;multidisciplinary;multiple omics;Needles;Onset of illness;Organ;Participant;Patients;Physicians;Population;Populations at Risk;pre-clinical;predictive modeling;Prevalence;prevent;Property;Proteins;Proteomics;Public Health;Punch Biopsy;Questionnaires;Recurrent disease;Relapse;Reporting;Research Personnel;response;Risk;sample collection;Sampling;Scientist;Scourge;Serum;Severity of illness;single-cell RNA sequencing;Skin;skin color;skin disorder;Statistical Models;Systemic disease;Systemic Lupus Erythematosus;Testing;Time;Tissue Sample;Tissues;tool;transcriptome sequencing;UV induced;Vitiligo

PROJECT_TITLE: Predictive drivers of new onset, relapse, and progression of human autoimmunity in skin


ADMINISTERING_IC: HG

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW HAVEN

ORG_DEPT: SURGERY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative We will continue the effort to promote the development of novel yet practical solutions for important privacy and security challenges in human genomic research, via organizing genomic privacy/security competitions and workshops, with emphasis on engaging/supporting researchers from nationally underrepresented groups to participate in our competitions and attend the workshops.

PI_NAMEs: JIANG, XIAOQIAN ;KUO, TSUNG-TING  (contact);TANG, HAIXU

PROGRAM_OFFICER_NAME: SEN, SHURJO KUMAR

PROJECT_TERMS: Academia;Acceleration;Address;Benchmarking;biomedical informatics;Biomedical Research;Caring;Code;Communities;Companions;computer science;Consent;cryptography;Data;Data Set;data sharing;Development;Educational workshop;Evaluation;Event;Extravasation;Family;Fellowship;Fingerprint;frontier;Funding;Future;Genome;genomic data;Genomics;Grant;Human;Human Genome;human genomics;Individual;Industry;innovation;Institution;interdisciplinary collaboration;interest;Knowledge;large scale data;Measures;meetings;Methods;Modeling;National Human Genome Research Institute;Nature;new technology;news;novel;Outsourcing;Paper;Participant;Patients;Performance;Postdoctoral Fellow;posters;preference;Privacy;privacy preservation;Privatization;prototype;Publications;Reporting;Research;Research Personnel;Research Project Grants;Rest;Risk;Secure;Security;Series;Side;Slide;Speech;Students;success;Surveys;task analysis;Technology;Testing;Time;tool;Travel;Underrepresented Minority;Underrepresented Populations;Voting;web portal;Woman

PROJECT_TITLE: iDASH Genome Privacy and Security Competition Workshop

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE The US needs well-prepared scientific workforce to advance prevention and treatment strategies to combat the diabetes and obesity epidemics. The University of Utah Interdisciplinary T32 Training Program in Metabolism provides this critical training that prepares future investigators for scientific careers in the field of diabetes and obesity-related metabolic disorders. This program leverages University of Utah’s robust Diabetes and Metabolism Research Center and serves an important regional need in the Intermountain West.

PI_NAMEs: SUMMERS, SCOTT A (contact)

PROGRAM_OFFICER_NAME: CASTLE, ARTHUR

PROJECT_TERMS: Metabolism;Training Programs

PROJECT_TITLE: Interdisciplinary Training Program in Metabolism


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Drug Abuse (NIDA only);Harm Reduction for Substance Misuse;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

PHR: Narrative The proposed study, Low-threshold buprenorphine treatment at syringe services programs: a Type I hybrid effectiveness-implementation trial, targets structural barriers to BUP treatment (e.g., health system fragmentation, waiting lists, and medical providers’ stigma towards people with OUD) by integrating BUP treatment into syringe services programs (SSPs). Dr Hansel Tookes from the Florida Node Alliance will serve as Co-Lead Investigator and will dedicate effort to protocol development activities.

PI_NAMEs: FEASTER, DANIEL J;METSCH, LISA R;SZAPOCZNIK, JOSE  (contact)

PROJECT_TERMS: Accident and Emergency department;Adoption;American;Buprenorphine;buprenorphine treatment;Client;Clinical Trials Network;Collaborations;Consolidated Framework for Implementation Research;cost;Counseling;Dedications;design;Development;drug testing;Drug user;Effectiveness;effectiveness outcome;effectiveness testing;effectiveness/implementation study;effectiveness/implementation trial;Enrollment;Equity;ethnic disparity;evidence base;flexibility;Florida;geographic disparity;Geographic Locations;Geography;Harm Reduction;harm reduction programs;Health Personnel;Health Services Accessibility;Health system;high risk;HIV;illicit opioid;implementation evaluation;implementation facilitators;implementation outcomes;implementation strategy;improved;Intervention;Link;Maintenance;marginalized population;Medicaid;Medical;medication for opioid use disorder;Methadone;Methods;Modeling;Morbidity - disease rate;mortality;multiple drug use;Needle-Exchange Programs;New York City;Opioid;opioid use;opioid use disorder;Outcome;Overdose;Overdose reduction;Participant;participant enrollment;Patient-Focused Outcomes;Persons;Phase;post implementation;Preparation;programs;protocol development;Provider;Quality of life;racial disparity;Randomized;Reach, Effectiveness, Adoption, Implementation, and Maintenance;Readiness;Reducing Agents;Research Personnel;Risk;service programs;Services;social stigma;Testing;transmission process;treatment duration;treatment services;Trust;Urine;Wait Time;Waiting Lists;Work

PROJECT_TITLE: Low-threshold buprenorphine treatment at syringe services programs: a Type I hybrid effectiveness-implementation trial” (CTN concept under development)


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Women's Health Research

ORG_CITY: CHAPEL HILL

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: NARRATIVE This program builds upon the highly successful UJMT Fogarty Global Health Fellowship, now in its tenth year. Its cornerstone is a 12-month, mentored research training opportunity at one of 30 institutions across Africa, Asia, and the Americas. We further strengthen the program with an innovative curriculum on research leadership, new approaches to enhance diversity in global health, and research platforms aligned with regional and international scientific priorities.

PI_NAMEs: CHECKLEY, WILLIAM ;CHI, BENJAMIN H. (contact);KONDWANI, KOFI A;OBERHELMAN, RICHARD A

PROGRAM_OFFICER_NAME: KATZ, FLORA N

PROJECT_TERMS: Academy;Active Learning;Address;Area;Award;base;career;Child Health;Collaborations;Communicable Diseases;Country;Critical Pathways;Development Plans;Disease;Educational Curriculum;Environmental Health;experience;Fellowship;Fostering;Funding;Future;global health;Government Programs;Grant;HIV/AIDS;improved;Individual;Institution;International;Investments;Leadership;Learning;Malignant Neoplasms;Manuscripts;Mental Health;Mentors;Monitor;Morehouse School of Medicine;National Institute of Environmental Health Sciences;Nervous System Disorder;North Carolina;Performance;Positioning Attribute;Postdoctoral Fellow;Process;Productivity;programs;Publishing;recruit;Research;Research Methodology;Research Personnel;Resources;Secure;Site;skills;Talents;Training;training opportunity;Training Programs;Underrepresented Populations;United States National Institutes of Health;Universities;Women's Health;Writing

PROJECT_TITLE: UJMT - NIEHS - Baldewsingh


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Patient Safety;Pediatric

PHR: Project Narrative  Gastroparesis is a disorder of gastric function characterized by delay in gastric emptying and frequently associated with chronic nausea and vomiting, early satiety, and abdominal pain. Gastroparesis is a disease affecting predominantly young women which can have a devastating impact on quality of life. The GpCRC aims to transform scientific discoveries from laboratory, clinical, and population studies into clinical applications to improve treatments and reduce the burden of adverse outcomes due to gastroparesis.

PI_NAMEs: SHADE, DAVID M (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Abdominal Pain;Adolescent;Adult;adverse outcome;Affect;Amendment;Ancillary Study;biobank;Biological Assay;Biometry;Biopsy;Buspirone;Catheters;Characteristics;Child;Childhood;Chronic;Clinic;Clinical;clinical application;clinical center;Clinical Data;clinical database;Clinical Management;Clinical Research;Clinical Trials;Clinical Trials Data Monitoring Committees;Code;Collaborations;Collection;Data;Data Analyses;data management;data repository;Databases;Development;Devices;Diagnosis;digital repositories;Disease;Disease Progression;Dyspepsia;early satiety;endophenotype;Equipment and supply inventories;Ethics;Etiology;FDA approved;Feces;follow-up;Funding;Future;Gastric Emptying;Gastric Tissue;Gastrointestinal Diseases;Gastroparesis;Genetic;genomic data;Guidelines;imaging probe;imaging study;Immune;improved;Incidence;Inflammatory Bowel Diseases;Institutional Review Boards;Investigational Drugs;Laboratory Study;Leadership;Maintenance;Manuscripts;Masks;Measures;meetings;Mission;Modeling;Modification;Molecular;Monitor;National Institute of Diabetes and Digestive and Kidney Diseases;Natural History;Nausea and Vomiting;novel therapeutics;nutrition;Nutritional;Observational Study;Output;Participant;Pathogenesis;Pathologic;Patients;pediatric patients;Performance;Peripheral Blood Mononuclear Cell;Persons;Phase;phase II trial;Physiological;Placebo Control;Plasma;Policies;Population Study;Preparation;Private Sector;Procedures;programs;prospective;protocol development;Protocols documentation;psychologic;public repository;public-private partnership;Publications;Pyloric sphincter structure;quality assurance;Quality of life;Radionuclide Imaging;Randomized;Registries;Reporting;repository;Research;Research Design;Research Personnel;Resources;Risk;Safety;Sample Size;Satiation;Scientist;Sensory;Serum;Shipping;Specimen;Stomach;Symptoms;Syndrome;Testing;Therapeutic Trials;Thick;Time;timeline;treatment response;treatment trial;Urine;Water;Work;young woman

PROJECT_TITLE: Continuation of the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC) 4


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE The goals of this project are to continue the New England Gastroparesis Collaborative to enroll patients in the NIH Gastroparesis Consortium where patients will then be entered into studies which are performed at multiple sites. We are planning for a multicenter Cognitive Behavioral Therapy in Gastroparesis Trial (COBIG 2.0) to reduce symptom burden.

PI_NAMEs: KUO, BRADEN  (contact)

PROJECT_TERMS: Abdomen;acceptability and feasibility;Address;Anxiety;avoidant restrictive food intake disorder;Behavioral;behavioral health;behavioral health intervention;Biological;biopsychosocial;biopsychosocial factor;Caring;Central Nervous System;central sensitization;Chronic;Clinical;Clinical Research;Clinical Trials;Cognitive Therapy;Complex;Defect;dietary restriction;Disease;disorders of gut-brain interaction;early satiety;Eating;efficacious treatment;Elements;Enteral;Enteric Nervous System;Epidemiology;follow-up;food avoidance;Functional disorder;Functional Gastrointestinal Disorders;Future;gastrointestinal;Gastrointestinal Diseases;gastrointestinal symptom;Gastroparesis;General Hospitals;Goals;GPR4 gene;Health;health care service utilization;improved;indexing;innovation;Intervention;Irritable Bowel Syndrome;Maintenance;Massachusetts;Medical;Morbidity - disease rate;mortality;Motor;motor disorder;Multicenter Studies;Natural History;Nature;Nausea and Vomiting;Neurobiology;neuroregulation;New England;novel;Pain;participant enrollment;Pathology;patient registry;Patient Self-Report;Patients;Peripheral;Phenotype;precision medicine;primary endpoint;profiles in patients;Protocols documentation;psychologic;Pyloric sphincter structure;Quality of life;Randomized, Controlled Trials;recruit;reduce symptoms;Registries;Research;research study;restrictive eating;Role;Screening procedure;secondary endpoint;Sensory;Severities;Site;Symptom Burden;Symptoms;targeted treatment;Testing;Therapeutic;Treatment outcome;United States National Institutes of Health;Validation;video delivery;Visceral

PROJECT_TITLE: New England Gastropareis Consortium: Neurobiology of Gastroparesis