NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Cardiovascular;Clinical Research;Disability Research;Hematology;Rehabilitation

ORG_NAME: UNIVERSITY OF MARYLAND BALTIMORE

PHR: Although Blood-contacting medical devices (BCMDs) have been used in lifesaving therapies for many patients, thrombotic and bleeding complications associated with platelet dysfunction induced by BCMDs tend to be devastating and often life-threatening. Current predictive models for device-induced platelet injury and altered platelet dysfunction are limited. This proposal aims to develop computational fluid dynamics (CFD) models, which incorporate new biomechanical models of shear-induced platelet activation and receptor shedding and are capable of predicting device-induced platelet activation and receptor shedding, and altered adhesion capacities to the substrate to aid the development and optimization of new BCMDs.

PI_NAMEs: WU, ZHONGJUN JON (contact)

PROGRAM_OFFICER_NAME: GOLDBERG, ILANA GRACE

PROJECT_TERMS: Adhesions;Adopted;Affect;Agonist;Algorithms;Animals;Anticoagulation;Assisted Circulation;Biocompatible Materials;Biology;biomaterial compatibility;biomechanical model;Biomechanics;Blood;Blood Cells;Blood Coagulation Factor;Blood flow;Blood Platelets;Blood Preservation;Calibration;Capsid Proteins;Characteristics;Chemicals;Coagulation Process;Collagen;Computer Models;Consumption;Coupled;Development;Device Designs;Device or Instrument Development;Devices;Disease;Event;experimental study;Extracorporeal Membrane Oxygenation;Fibrinogen;Functional disorder;Generations;Geometry;Hemodialysis;Hemolysis;Hemorrhage;Hemostatic Agents;Hemostatic function;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;indexing;Injury;innovation;Laws;Life;Link;Liquid substance;Mechanical Stress;Medical Device;Modeling;Morphology;novel;Organ;Organ Transplantation;Patients;Pattern;Performance;Platelet Activation;Postoperative Complications;predictive modeling;predictive tools;Property;Proteins;prototype;Quantitative Evaluations;receptor;Research;Risk;Scheme;Self-Help Devices;shear stress;Sheep;sheep model;simulation;Structure;success;Surface;surface coating;Techniques;Testing;Thrombosis;thrombotic;tool;Transplantation;Trauma;ventricular assist device;virtual;VWF gene

PROJECT_TITLE: Computational Modeling of Device-Induced Platelet Activation and Receptor Shedding Relevant to Thrombosis and Bleeding in Device-Assisted Circulation

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Immunotherapy;Neurosciences;Orphan Drug;Rare Diseases

ORG_CITY: WINSTON-SALEM

ORG_COUNTRY: UNITED STATES

ORG_DEPT: BIOLOGY

ORG_FIPS: US

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: NARRATIVE Glioblastoma (GBM) is an incurable primary brain tumor of high heterogeneity. This heterogeneity is one of the major obstacles to GBM treatment. To this end, we identified four molecular targets that are over-expressed collectively in all patients with GBM, but not normal brain. This is a unique development and we generated cytotoxic drug conjugates targeting these receptors simultaneously with an increased access to tumors to produce effective molecular resection with long-lasting anti-tumor response. In addition, we will also inflame these immunologically cold tumors with a targeted conjugate so they can mount more effective immune responses to complement the direct killing action of the cytotoxins. This approach has a great potential of significantly improving the management of the disease.

PI_NAMEs: DEBINSKI, WALDEMAR  (contact);ROSSMEISL, JOHN HENRY

PROGRAM_OFFICER_NAME: CARDONE, MARCO

PROJECT_TERMS: Address;Affinity;Antineoplastic Agents;antitumor effect;Antitumor Response;assault;Bacterial Toxins;Binding;Biopsy;Blood;Brain;Canis familiaris;Catheters;Cell Separation;Cells;Clinical;Combination immunotherapy;Complement;Convection;Cytotoxic agent;Cytotoxin;design;Development;Disease Management;Dose;Dose Limiting;Doxorubicin;drug distribution;Drug Monitoring;effective therapy;EphA2 Receptor;EPHA3 gene;EphB2 Receptor;Ephrins;Excision;experimental study;Genotype;Glioblastoma;Glioma;Heterogeneity;human disease;human model;IgG1;IL13RA1 gene;Immune response;Immune system;Immunologics;improved;in situ vaccination;Infiltration;interest;Interleukin-13;Intravenous;Ligand Binding;Long-Term Survivors;Macrophage;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Medicine;Microtubules;Modality;Molecular;Molecular Target;monocyte;Mus;mutant;neoplastic cell;neovasculature;Newly Diagnosed;novel;overexpression;Patients;Pharmaceutical Preparations;Pharmacologic Substance;Phase I Clinical Trials;Phenotype;Play;Primary Brain Neoplasms;Primary Neoplasm;Property;Pseudomonas aeruginosa toxA protein;Quality of life;receptor;Recurrence;Recurrent tumor;Reflux;Research;Resistance;response;Rodent;Role;scaffold;self-renewal;Stains;stem;stem-like cell;success;Testing;Therapeutic;Therapeutic Intervention;therapy resistant;Time;Tissues;Toxic effect;transcriptome sequencing;translational model;tumor;tumor heterogeneity;tumor microenvironment;tumor progression;Tumor Volume;Tumor-associated macrophages;tumor-immune system interactions;Tumorigenicity

PROJECT_TITLE: Combinatorial Immunotherapy using a Multivalent Drug Conjugate for GBM Treatment


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Emerging Infectious Diseases;Immunization;Infectious Diseases;Malaria;Malaria Vaccine;Orphan Drug;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: BALTIMORE

ORG_DEPT: PEDIATRICS

ORG_STATE: MD

PHR: Project Narrative Advancing vaccines, treatments, and other tools for preventing and controlling endemic, epidemic and emerging infectious diseases that threaten health and well-being is a top NIAID and public healthy priority. In its capacity as a longstanding and accomplished VTEU, the University of Maryland Center for Vaccine Development and Global Health (CVD) proposes to harness our innovation, technical capacity, in-depth subject matter expertise, and broad network of domestic and international collaborators to achieve program goals. We will work collaboratively with VTEU sites and leadership to identify and implement the highest quality clinical research across NIAID priority areas, while mentoring and developing the next generation of clinical scientists.

PI_NAMEs: KOTLOFF, KAREN L. (contact)

PROGRAM_OFFICER_NAME: BURNHAM, ANDREW JAMES

PROJECT_TERMS: Academia;Address;Africa;Age;age group;Ambulatory Care Facilities;Area;Award;Biological Products;Clinic;Clinical;Clinical Protocols;Clinical Research;clinical research site;Clinical Trials;Collaborations;Communicable Diseases;Communities;Conduct Clinical Trials;Consultations;Contracts;Country;COVID-19;design;Devices;Diagnosis;Diagnostic;diagnostic tool;Disease;Disease Outbreaks;dosage;Ebola;Emerging Communicable Diseases;Enrollment;Enteral;enteric pathogen;Epidemic;epidemiology study;Equipment;Evaluation;experience;Formulation;Funding;global health;Goals;Government;Government Agencies;Guidelines;Health;healthy volunteer;Hospitalization;Human;Human Resources;human subject;Immune response;improved;Industry;Infection;Influenza;innovation;International;Intervention;Investigation;Laboratories;Laws;Leadership;Malaria;Maryland;Medical Device;medical schools;Mentors;Methods;microbiota;Modeling;National Institute of Allergy and Infectious Disease;neglected tropical diseases;next generation;Nongovernmental Organizations;novel;novel diagnostics;novel vaccines;organizational structure;Outpatients;Participant;pathogen;patient population;Patients;Personal Satisfaction;Phase;Policies;Population;population based;pre-clinical;predictive marker;Pregnant Women;prevent;Prevention;Prevention trial;Preventive;product development;Prognostic Marker;Program Development;programs;Protocols documentation;Public Health;public health emergency;public health priorities;Publishing;Qualifying;Reagent;Regulation;Reporting;Research;Research Personnel;research study;Research Subjects;Resources;Respiratory Tract Infections;response;Risk;sample collection;Sampling;Schedule;Scientist;serosurvey;Services;Sexually Transmitted Diseases;Site;skills;Source;System;Systems Biology;targeted delivery;Therapeutic;tool;treatment trial;United States National Institutes of Health;Universities;vaccine access;vaccine candidate;vaccine development;vaccine evaluation;Vaccines;Vulnerable Populations;Work

PROJECT_TITLE: Implementing Vaccine and Treatment Evaluation Unit (VTEU) Clinical Site


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Dementia;Dissemination and Implementation Research;Neurodegenerative

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Project Narrative  Although considerable investment in dementia care science has occurred, questions continue as to whether the existing evidence base is sufficient to warrant widespread dissemination and implementation of innovations to improve the health and well-being for people living with dementia and their caregivers. My short- term career career objective and the focus of this K07 is to implement graduate curricula, extensive mentoring, and robust support to enhance pre- and post-doctoral training in the science of dementia care interventions (the Advanced Behavioral Intervention Design in Dementia Care program). The long-term objective that will result from the proposed K07 is the creation, leadership, and maintenance of infrastructure at the University of Minnesota that serves as a national resource for advanced methodology in dementia care intervention science.

PI_NAMEs: GAUGLER, JOSEPH E. (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Acute;Address;Adoption;advanced dementia;Aging;Alzheimer's Disease;Alzheimer's disease related dementia;Award;Behavior Therapy;Behavioral Model;care systems;career;career development;Caregivers;caregiving;Caring;Clinical Research;Clinical Trials;collaboratory;cost;Course Content;Dementia;dementia care;design;Development;Dissemination and Implementation;Educational Curriculum;Elderly;Emergency Care;Endowment;evidence base;Failure;Family;Family Caregiver;Fertility Rates;Generations;Gerontology;graduate student;Grant;Health;health care delivery;health care service;health care settings;Healthcare Systems;healthy aging;implementation efforts;implementation science;improved;Individual;Infrastructure;innovation;Intervention;Intervention Studies;Investments;Lead;Leadership;Long-Term Care;Maintenance;Mentors;Meta-Analysis;Methodology;Methods;Minnesota;Minor;Modeling;peer;peer coaching;Performance;Personal Satisfaction;Persons;Positioning Attribute;post-doctoral training;Postdoctoral Fellow;postdoctoral investigator;pragmatic trial;pre-doctoral;Preparation;pressure;Prevalence;programs;Provider;Public Health Schools;recruit;Reporting;Research;Research Personnel;Resources;Role;Science;service delivery;Services;skills;sociodemographics;success;symposium;systematic review;therapy design;Training;trend;United States;United States National Institutes of Health;Universities;Woman

PROJECT_TITLE: Academic Leadership Career Award

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Established Investigators and Conference Grants Study Section[AGCD-4]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Multiple Sclerosis;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Autoimmune diseases are caused by the dysregulated activity of the immune system. This competitive renewal proposes to use unique experimental systems to study the mechanisms by which the aryl hydrocarbon receptor controls the immune response, and to identify potential therapeutic targets for immune-mediated diseases.

PI_NAMEs: QUINTANA, FRANCISCO J. (contact)

PROGRAM_OFFICER_NAME: HUMBLE, MICHAEL C

PROJECT_TERMS: Adenosine;Agonist;Anti-Inflammatory Agents;Aryl Hydrocarbon Receptor;Autoimmune;Autoimmune Diseases;Autoimmunity;Cell Physiology;Cells;Central Nervous System;Classification;Clinical;CNS autoimmunity;conditional knockout;cytokine;Data;Dendritic cell activation;Dendritic Cells;Development;Disease;disorder control;Engineered Probiotics;Epigenetic Process;Eragrostis;Escherichia coli;Experimental Autoimmune Encephalomyelitis;Experimental Models;extracellular;Gene Expression;Generations;Genetic Transcription;Genomics;Goals;Grant;gut-brain axis;Human;Immune;Immune response;Immune system;Immune Targeting;in vivo;indoleacetic acid;Inflammation;Inflammatory;interest;Knockout Mice;Ligands;Macrophage;Mediating;microbial;microbiome;Multiple Sclerosis;multiple sclerosis patient;multiple sclerosis treatment;Mus;Myelin;Names;Nervous System Disorder;NF-kappa B;novel;novel therapeutic intervention;novel therapeutics;Pathogenesis;Pathogenicity;Pathology;Pathway interactions;Patients;Phenotype;Play;Pre-Clinical Model;programs;Publishing;Receptor Activation;Regulation;Regulatory T-Lymphocyte;response;Role;Sampling;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Source;System;T cell differentiation;T cell response;T-Lymphocyte;Therapeutic;Therapeutic Effect;therapeutic target;tool;transcription factor;Transcriptional Regulation;Work

PROJECT_TITLE: Role of AHR in Dendritic Cells in the Control of CNS Autoimmunity

STUDY_SECTION: HAI

STUDY_SECTION_NAME: Hypersensitivity, Autoimmune, and Immune-mediated Diseases Study Section[HAI]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Dental, Oral, and Craniofacial Disease;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Rare Diseases

ORG_CITY: CINCINNATI

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CINCINNATI

ORG_STATE: OH

PHR: PROJECT NARRATIVE The body fights solid tumors by engaging immune cells called T lymphocytes that kill cancer cells. As these cells need Kv1.3 ion channels to perform this function, in this proposal we aim to develop new cancer immunotherapy treatments that increase the number of Kv1.3 channels in T lymphocytes from cancer patients.

PI_NAMEs: CONFORTI, LAURA  (contact)

PROGRAM_OFFICER_NAME: SOMMERS, CONNIE L

PROJECT_TERMS: Address;Adenosine;anti-PD1 therapy;Antibodies;Artificial nanoparticles;Biological Assay;Blocking Antibodies;cancer cell;cancer immunotherapy;cancer infiltrating T cells;Cancer Patient;cell motility;Cell Physiology;Cells;Characteristics;Chemotaxis;chemotherapy;combinatorial;COVID-19;cytokine;Cytotoxic T-Lymphocytes;cytotoxicity;Death Rate;design;disease model;Effectiveness;Electrophysiology (science);Failure;fighting;Formulation;Goals;Head and Neck Squamous Cell Carcinoma;high risk;humanized mouse;Immune;immune cell infiltrate;Immune checkpoint inhibitor;Immunologic Surveillance;Immunotherapy;improved;In Vitro;in vivo;Infiltration;interest;Investigational Therapies;Ion Channel;Laboratories;lipid nanoparticle;Liposomes;Malignant Neoplasms;Mediating;Melanoma;Membrane Potentials;Messenger RNA;Methods;migration;mouse model;mRNA immunotherapy;Mus;nanoparticle;Nature;novel therapeutic intervention;Oncologist;Operative Surgical Procedures;Organoids;overexpression;patch clamp;Patients;Peptides;Potassium Channel;Production;programmed cell death protein 1;Property;Purinergic P1 Receptors;Radiation therapy;Relapse;Research;Resistance;Resistance development;response;RNA vaccine;Shapes;side effect;Signal Pathway;Solid;Solid Neoplasm;Specificity;Survival Rate;T cell infiltration;T cell therapy;T-Lymphocyte;targeted delivery;Testing;Toxic effect;trafficking;tumor;Tumor Burden;tumor microenvironment;tumor progression;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: Liposome-based mRNA cancer immunotherapy targeting ion channels


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: Princeton

ORG_DEPT: CHEMISTRY

ORG_NAME: PRINCETON UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative This proposal describes the development of electronically-controlled, site-selective C–H functionalization as a broadly applicable tool for the synthesis and discovery of medicinally-relevant compounds. The unique features of Earth-abundant, first row transition metals distinguish the various types of C–H bonds found in common organic building blocks based on their inherent electronic differences. This recognition enables a retrosynthetic tool that will open new molecular space and overcome the structural biases that result from existing metal-catalyzed methods.

PI_NAMEs: CHIRIK, PAUL J (contact)

PROGRAM_OFFICER_NAME: YANG, JIONG

PROJECT_TITLE: Earth abundant catalysts as an enabling tool for organic synthesis

STUDY_SECTION: SBCB

STUDY_SECTION_NAME: Synthetic and Biological Chemistry B Study Section[SBCB]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CAMBRIDGE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE: Vimentin intermediate filaments are a key regulator of mammalian cell shape, mechanical integrity, and motility, but remain poorly understood for groups of cells embedded within 3D extracellular matrix. Here, we investigate the role of vimentin in cellular deformability, matrix adhesion, and multicellular coordination during directed migration. These fundamental studies will enable new insights into the structure and function of vimentin during physiological processes, as well as its dysregulation in pathologic states.

PI_NAMEs: GUO, MING  (contact);WONG, IAN Y

PROGRAM_OFFICER_NAME: RIGAS, MARC

PROJECT_TERMS: 3-Dimensional;Actomyosin;Adhesions;Affect;Biochemical;Cadherins;Cell Communication;Cell Line;cell motility;Cell Nucleus;Cell Shape;cell type;Cell-Cell Adhesion;Cells;Cellular Spheroids;Collagen;Cytoplasm;Cytoskeleton;Embryonic Development;Epithelial Cells;Epithelium;Exhibits;Extracellular Matrix;Focal Adhesions;Genetic;Geometry;Individual;insight;Intercellular Junctions;Intermediate Filaments;knock-down;Knock-out;Label;laser tweezer;Mammalian Cell;matrigel;Measurement;mechanical signal;Mechanics;Mesenchymal;Microfluidics;migration;Molecular and Cellular Biology;Molecular Biology;Morphogenesis;Morphology;mosaic;Motility;optic tweezer;overexpression;particle;Pathologic;Phenotype;Physiological Processes;Population;Proteins;Research Personnel;Rheology;Role;Speed;spheroids;Structure;Technology;Tissues;Tracer;Traction;Traction Force Microscopy;transmission process;tumor;Tumor Cell Invasion;Vimentin;Work;wound;wound healing

PROJECT_TITLE: Mechanobiology of Vimentin Intermediate Filaments in 3D Collective Cell Migration

STUDY_SECTION: ICI

STUDY_SECTION_NAME: Intercellular Interactions Study Section[ICI]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MISSOULA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: PROJECT NARRATIVE GluN3 subunit-containing NMDA receptors are implicated in synapse maturation, synaptic plasticity, and have been linked to several central nervous system disorders, but fundamental properties of GluN3-containing NMDA receptors remain unresolved. The lack of GluN3-selective pharmacology, incomplete understanding of neuronal GluN3-containing receptors, and enigmatic functional properties are barriers to progress in our understanding of their physiological roles. The overarching goal of this project is to mitigate these barriers and guide future studies on neuronal signaling by GluN3-containing NMDA receptors, which are needed to advance GluN3 subunits as therapeutic targets.

PI_NAMEs: HANSEN, KASPER BOE (contact)

PROGRAM_OFFICER_NAME: CHURN, SEVERN BORDEN

PROJECT_TERMS: Affinity;Agonist;Alternative Splicing;antagonist;Binding;Binding Sites;Brain;Cells;Central Nervous System;Central Nervous System Diseases;cofactor;Collaborations;Computer Models;Dendritic Spines;density;desensitization;Development;dimer;Electrophysiology (science);Exposure to;Future;gene gun;gene replacement;Glutamate Receptor;Glutamates;Glycine;Goals;Hippocampus;improved;Ion Channel;Ion Channel Gating;Lead;Ligand Binding;Ligands;Link;Measures;Mediating;Modification;Molecular;Molecular Conformation;Mus;mutant;Mutation;N-Methyl-D-Aspartate Receptors;N-Methylaspartate;Neurons;neurotransmission;NMDA receptor A1;novel;Permeability;Pharmaceutical Chemistry;pharmacologic;Pharmacology;Physiological;Physiology;prevent;Property;Pyramidal Cells;receptor;Recombinants;response;Role;Slice;structural determinants;Structure;Structure-Activity Relationship;Synapses;Synaptic plasticity;therapeutic target;tool;Transfection;Variant;Vertebral column;Wild Type Mouse

PROJECT_TITLE: Physiology and pharmacology of GluN3-containing NMDA receptors

STUDY_SECTION: MNPS

STUDY_SECTION_NAME: Molecular Neuropharmacology and Signaling Study Section[MNPS]


NIH_SPENDING_CATS: Cancer;Childhood Leukemia;Hematology;Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: PROJECT NARRATIVE The proposed research is relevant to the public health because acute myeloid leukemia represents a major national cost measured by both patient suffering, diminished years of life, and economic burden. Despite recent advances in drug development, clinical trial data demonstrate that a minority of acute myeloid leukemia patients are cured, and the majority succumb to their disease, typically within two years following diagnosis. Upon conclusion, we will likely have two potential treatment options that have significant promise for effectively preventing/treating the two most common mechanisms of resistance to potent FLT3 inhibitor therapy, and which are expected to forestall or prevent disease relapse and improve outcomes in a subset of AML patients substantially.

PI_NAMEs: LI, HONG-YU ;SHAH, NEIL P (contact)

PROGRAM_OFFICER_NAME: AGYIN, JOSEPH KOFI

PROJECT_TERMS: ABL1 gene;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Address;Amino Acids;Apoptosis;Binding;Biological Assay;Biology;Cell Line;Cells;Chemicals;Chronic Myeloid Leukemia;Clinical;clinical investigation;Clinical Trials;clinically relevant;Computing Methodologies;Cost Measures;cytotoxicity;Data;Dependence;design;Development;Diagnosis;Disease;Disease Resistance;disorder control;Docking;Dose Limiting;drug development;Drug resistance;Economic Burden;Evaluation;FLT3 gene;FLT3 inhibition;FLT3 inhibitor;Genes;Goals;Government;Grant;Hematology;Hematopoiesis;Human;improved;improved outcome;In Vitro;in vivo;in vivo Model;Incidence;inhibitor;inhibitor therapy;innovation;insight;kinase inhibitor;Lead;leukemia;Life;Malignant Neoplasms;Mediating;Mediator;Medical;Methodology;Minority;Modeling;Molecular;Molecular Probes;mouse model;Mus;Mutagenesis;mutant;Mutate;Mutation;Myeloproliferative disease;Myelosuppression;novel;novel therapeutic intervention;novel therapeutics;off-target mutation;Outcome;Pathologic;Pathway interactions;Patients;Persons;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Positioning Attribute;pre-clinical;prevent;Prognosis;Property;Protein Kinase;protein structure;Protein Tyrosine Kinase;Public Health;Recurrent disease;Remission Induction;Research;Resistance;Resistance development;resistance mechanism;resistance mutation;Roentgen Rays;Route;Sampling;scaffold;Series;Specificity;structural biology;Structure-Activity Relationship;targeted treatment;Testing;Therapeutic;Therapeutic Agents;Therapeutic Index;therapeutic target;therapy outcome;tool;Toxic effect;translational study;Tyrosine Kinase Inhibitor;Work

PROJECT_TITLE: Development of Potent, Selective, Non-Myelotoxic FLT3 Inhibitors that Retain Efficacy Against Common Mechanisms of Resistance

STUDY_SECTION: DMP

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology Study Section[DMP]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Kidney Disease;Lupus

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: Relevance Inflammatory kidney diseases such as glomerulonephritis, diabetic kidney disease and lupus nephritis are associated with significant comorbidities and mortalities and affect close to a third of the US population, yet their pathophysiology remains incompletely understood. Macula densa cells play pivotal roles in the maintenance of the normal structure and function of the healthy glomerulus and also in the development of glomerular injury in kidney diseases, yet their primary immunomodulatory role has been largely overlooked. We propose to study the role of macula densa cells and their pro and anti- inflammatory function in the normal and diseased kidney, and to develop new therapeutic approaches for inflammatory kidney diseases.

PI_NAMEs: PETI-PETERDI, JANOS  (contact)

PROGRAM_OFFICER_NAME: SADUSKY, ANNA BURKART

PROJECT_TERMS: Affect;Anatomy;Anti-Inflammatory Agents;Antibodies;Antiinflammatory Effect;Blood Vessels;CD3 Antigens;CD44 gene;Cd68;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Culture Techniques;cell growth;Cell Physiology;Cell Separation;cell type;Cells;Cellular Infiltration;chemokine;Chemotaxis;comorbidity;cytokine;Cytometry;density;Development;diabetic;Diabetic Nephropathy;Disease;Extracellular Matrix;FRAP1 gene;Functional disorder;Future;gain of function;Genes;Genetic;glomerular endothelium;Glomerulonephritis;Health;hemodynamics;Home;Homing;Immune;immunoregulation;improved;In Vitro;in vivo;Inflammation;Inflammatory;Inflammatory Response;inhibitor;Injury;Kidney;kidney cell;kidney cortex;Kidney Diseases;Knock-out;Label;Laboratories;Leucocytic infiltrate;loss of function;Lupus Nephritis;Macula densa;Maintenance;Microcirculation;microscopic imaging;migration;Modeling;Molecular;mortality;multiphoton microscopy;Mus;nephrotoxicity;non-diabetic;novel therapeutic intervention;optogenetics;paracrine;Pathway interactions;Pattern;Physiological;Play;Population;Positioning Attribute;pre-clinical;Property;Protein Biosynthesis;Proteins;Proteomics;PTPRC gene;Role;Serum;Signaling Protein;single-cell RNA sequencing;Streptozocin;Stromal Cell-Derived Factor 1;Structure;systemic inflammatory response;Testing;Therapeutic;Time;Tissues;tool;transcriptome;transcriptomics;Transgenic Mice;translational therapeutics;vascular bed;Work

PROJECT_TITLE: A new paradigm of glomerular immune cell homing

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-W(05)]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health

ORG_CITY: STONY BROOK

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

ORG_STATE: NY

PHR: Compared to physical health , population mental health in the U .S. is poorly monitored . With validated methods to accurately measure over space and time, social media language analyses can offer a substantially extended monitoring system , with estimates multiple times a year, at fine-grained levels of spatial aggregation, and enabling quasi-experimental designs to spot emerging trends.

PI_NAMEs: EICHSTAEDT, JOHANNES C.;SCHWARTZ, HANSEN ANDREW (contact)

PROGRAM_OFFICER_NAME: BURSTEIN, MARCY ELLEN

PROJECT_TITLE: SCH: Advancing Language-based Analyses of Social Media to Reliably Monitor Variation in Population


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Nanotechnology;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Transplantation

ORG_CITY: SCOTTSDALE

ORG_NAME: MAYO CLINIC ARIZONA

ORG_STATE: AZ

PHR: PROJECT NARRATIVE Heart regeneration holds great promise to treat ischemic heart diseases, which have long been the leading cause of death worldwide. The long term goal and the clinical significance of this project are to engineer a novel human heart tissue with robust myocardial regeneration and repairing potency. The results from these studies will serve as an important platform to enhance future therapeutic initiatives aimed at heart regeneration.

PI_NAMEs: XIE, JINGWEI ;ZHU, WUQIANG  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TERMS: 3-Dimensional;Acute;Acute myocardial infarction;Address;Adult;Animal Model;Animals;Area;Birth;Cardiac;cardiac magnetic resonance imaging;Cardiac Myocytes;cardiac regeneration;cardiac tissue engineering;Catheters;Cause of Death;Cell Cycle;Cell Proliferation;Cell Survival;Cell Therapy;Cells;Chronic;Cicatrix;clinical application;Clinical Research;Clinical Trials;clinically significant;Coronary;coronary artery occlusion;Data;Diameter;Effectiveness;Engineering;Engraftment;Exhibits;Family suidae;FGF1 gene;follow-up;functional restoration;Future;Gelatin;Glass;Goals;Heart;heart dimension/size;Heart failure;heart function;high risk;Human;human embryonic stem cell transplantation;human induced pluripotent stem cells;Implant;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Infarction;Injectable;Injections;injured;Injury;Intervention;ischemic injury;Mediating;minimally invasive;Modeling;mortality risk;Mus;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;Myosin Heavy Chains;Nanofiber Scaffold;nanomaterials;nanoparticle;Natural regeneration;novel;novel strategies;Nude Rats;Operative Surgical Procedures;overexpression;Patients;Perfusion;pre-clinical;preclinical study;Procedures;Proliferating;promoter;Protocols documentation;Rattus;repaired;revascularization;Safety;safety engineering;Shapes;Stem cell transplant;Systolic heart failure;Techniques;Technology;Therapeutic;Thoracic Surgical Procedures;Thoracoscopy;Tissue constructs;Tissue Engineering;Tissue Transplantation;Tissues;Transgenes;Transplantation;Tube;tumorigenesis;Vascularization;vasculogenesis;Vasculogenic;Ventricular Cardiac alpha-Myosin;Virus

PROJECT_TITLE: Strategies to Enhance Engineered Heart Tissue Based Myocardial Repair

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

PHR: PROJECT NARRATIVE  Fundamental questions remain about the origin of brain blood vessel cells and their interactions with the developing neural tissue. This project will define how human brain mural cells contribute to angiogenesis and neurogenesis and build a suite of tools to interrogate specific signaling pathways in mural cells. This knowledge is clinically relevant to dissect how the developing vasculature contributes to brain maturation and specifically to understand a devastating brain hemorrhage that occurs in preterm infants.

PI_NAMEs: CROUCH, ELIZABETH ERIN (contact)

PROGRAM_OFFICER_NAME: KOENIG, JAMES I

PROJECT_TERMS: 3-Dimensional;Adult;Affect;Age;angiogenesis;Astrocytes;Atlases;Autopsy;Biological Assay;Biology;Blood - brain barrier anatomy;Blood flow;Blood Vessels;Brain;Brain hemorrhage;Brain Injuries;Brain region;brain tissue;capillary bed;Cell Culture Techniques;Cell Lineage;Cells;cerebral mural cells;Cerebral Palsy;cerebrovascular;Cerebrovascular system;Cessation of life;clinically relevant;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR/Cas technology;CSPG4 gene;Data;Development;differential expression;Elements;Endothelial Cells;Endothelium;experimental study;Fluorescence-Activated Cell Sorting;Future;Genes;Gestational Age;Goals;Hemorrhage;high risk;Human;human tissue;Immunohistochemistry;In Vitro;in vivo;Infant;Intellectual functioning disability;Knowledge;lateral ventricle;Lead;Location;matrigel;Mental Depression;Modeling;Molecular;mouse model;Mus;Neonatal;neonatal mice;Nerve Degeneration;nerve stem cell;neural;neurogenesis;neuroinflammation;Neurons;neuropathology;neurovascular;NOTCH3 gene;novel;Organoids;Pathogenesis;Pathologic;patient population;Pattern;Pericytes;perinatal medicine;Perinatal subependymal hemorrhage;Physicians;Physiological;Platelet-Derived Growth Factor beta Receptor;Play;Population;Pregnancy;premature;Premature Infant;progenitor;Proliferating;Research Personnel;response;Role;Scientist;Signal Pathway;single-cell RNA sequencing;Smooth Muscle Myocytes;stem cell biomarkers;stem cell population;stem cells;Structure;Testing;Tissues;tool;Training;Transplantation;Tube;Ventricular

PROJECT_TITLE: Mural stem cells in normal development and germinal matrix hemorrhage in the preterm human brain

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative The first critical step for HIV to enter host cells and establish infection is membrane fusion, which is catalyzed by its envelope glycoprotein. This proposal aims to determine high-resolution structures of the intact envelope proteins from different isolates in the context of membrane to fill a major gap in our understanding of viral entry.

PI_NAMEs: CHEN, BING  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Adopted;Antibodies;Antigens;Binding;Biochemical;CCR5 gene;CD4 Antigens;Cells;chemokine receptor;Complex;Cryoelectron Microscopy;CXCR4 gene;Cytoplasmic Protein;Cytoplasmic Tail;env Gene Products;Environment;gag Gene Products;Genetic;Genetic Variation;Glycoproteins;Goals;gp160;HIV;HIV Envelope Protein gp120;HIV-1;HIV-1 vaccine;Infection;Lead;Length;Lipid Bilayers;Lipids;matrix protein, Human immunodeficiency virus type 1;Mediating;Membrane;Membrane Fusion;Membrane Proteins;Molecular;Molecular Conformation;nanodisc technology;nanodisk;novel;particle;Play;Probability;Process;protein reconstitution;protein structure;Proteins;Protocols documentation;receptor;receptor binding;reconstitution;Reporting;Resistance;Resolution;Role;Sampling;Series;structural biology;Structure;Technology;Transmembrane Domain;Vaccine Design;vaccine development;Variant;Viral;Virus;Visualization

PROJECT_TITLE: Structure of HIV-1 envelope spike in the context of membrane

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Burden of Illness;Cardiovascular;Clinical Research;Heart Disease;Kidney Disease;Neurosciences;Prevention

ORG_CITY: NEW YORK

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative Hemodialysis patients have a high incidence of cardiovascular death despite use of an outsized proportion of Medicare funds on their care. Our proposal will improve understanding of the epidemiology of and mechanisms underlying transient intradialytic myocardial stunning, a novel and potentially critical complication of hemodialysis that may damage the heart and increase cardiovascular mortality. These studies will provide the necessary data to design trials of novel therapies to prevent intradialytic stunning and advance progress towards novel, life-saving therapies for this high-risk population.

PI_NAMEs: CHARYTAN, DAVID M (contact);HERZOG, CHARLES A

PROGRAM_OFFICER_NAME: SHI, YANG

PROJECT_TERMS: Acute;Address;American;Arrhythmia;Attention;attributable mortality;Autonomic Dysfunction;Autonomic nervous system;autonomic reflex;Baroreflex;Biological Markers;black patient;Black Populations;Blood Pressure;Cardiac;cardiovascular risk factor;Cardiovascular system;Caring;Catecholamines;Cessation of life;Cities;cohort;Collaborations;Complication;Data;Death Rate;Dedications;design;Development;Dialysis patients;Dialysis procedure;Echocardiography;End stage renal failure;Epidemiology;Event;Expenditure;Functional disorder;Funding;Heart;heart damage;Heart failure;Hemodialysis;hemodynamics;high risk;high risk population;Hispanic;Hispanic Populations;Hormones;Impairment;improved;Incidence;innovation;insight;Intervention Trial;Investigation;Knowledge;Lead;Left;Left Ventricular Hypertrophy;Life;Link;Maintenance;Measurement;Measures;Medicare;Modality;Monitor;Morbidity - disease rate;mortality;Motion;Multicenter Studies;Myocardial;myocardial damage;Myocardial dysfunction;Myocardial Ischemia;Myocardial Stunning;Necrosis;Nervous System control;neuroimaging;Neurons;neurophysiology;new therapeutic target;Norepinephrine;novel;novel therapeutics;Osmolar Concentration;Pathogenesis;Pathologic;patient subsets;Patients;Pattern;Phenotype;Physiology;Plasma;Population;Positron-Emission Tomography;Predisposition;Prevalence;prevent;Procedures;Publishing;Recurrence;Reflex action;Research Design;response;Risk Factors;Role;Sampling;Stress;Stress cardiomyopathy;Subgroup;sudden cardiac death;Sympathetic Nervous System;Syndrome;targeted treatment;Testing;Time;Toxic effect;trial design;Ultrafiltration;United States;United States National Institutes of Health;Variant;Ventricular;Woman

PROJECT_TITLE: Intradialytic Myocardial Stunning in Hemodialysis Patients - a Novel Cardiovascular Risk Factor

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Maternal Health;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Women's Health Research

ORG_CITY: GALVESTON

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: PROJECT NARRATIVE Preterm birth (PTB) is a birth before 37 weeks of gestation period. Current therapeutic strategies either doesn't cross the fetal-maternal interface or causes toxicity to fetal tissues. We developed a safe, stable, and inert nanoparticle (exosomes) to delay preterm birth with natural anti-inflammatory cytokine interleukin (IL)-10.

PI_NAMEs: KAMMALA, ANANTH KUMAR  (contact);MENON, RAMKUMAR

PROGRAM_OFFICER_NAME: REN, ZHAOXIA

PROJECT_TERMS: 37 weeks gestation;Address;Amniotic Fluid;Animals;Anti-Inflammatory Agents;Bacteria;Bacterial Infections;Biodistribution;Biogenesis;Biological;Birth;Cd68;CD81 gene;Cells;cervical remodeling;Cervical Ripening;Cervix Uteri;chemokine;Clinical Trials;cohort;confocal imaging;cost effective;cytokine;cytotoxicity;Data;delivery vehicle;design;Development;Dexamethasone;Dose;Drug Delivery Systems;drug development;drug testing;Drug Transport;Dyes;effective therapy;efficacy evaluation;efficacy testing;Electron Microscope;Electroporation;Encapsulated;engineered exosomes;Engineering;Ensure;Escherichia coli;Euthanasia;Exclusion;exosome;Exposure to;extracellular;extracellular vesicles;fetal;Fetal Membranes;Fetal Reduction;Fetal Tissues;Fetus;Future;Hour;human fetal cells;Image;imaging system;Immune;Immune Tolerance;improved;In Vitro;in vivo;in vivo imaging system;Incidence;Infection;Inflammation;Inflammatory;Inflammatory Response;innovation;Interleukin-10;Intervention;Intravenous;Investigational Drugs;Label;lipophilicity;Lipopolysaccharides;Macrophage;Maternal-Fetal Exchange;Maternal-Fetal Medicine Units Network;Mediating;Metabolic;Methods;Modeling;Monitor;Morphology;Mothers;mouse model;Mus;nanoparticle;neonatal morbidity;Neonatal Mortality;neonate;NF-kappa B;novel therapeutics;Pathologic;Pharmaceutical Preparations;Physiological;Placenta;Plasma;Plasmids;Pregnancy;Pregnancy Outcome;Premature Birth;Production;Prolonged Pregnancy;Property;Proteins;Recombinants;Risk;Risk Factors;risk minimization;Sampling;success;Surface;Teratogens;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;Toxic effect;trafficking;Transcription Coactivator;Translating;Tropism;Ultracentrifugation;United States;Uterine Contraction;Uterus

PROJECT_TITLE: Developing IL-10 encapsulated exosomes as novel therapeutics for spontaneous preterm birth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Reproduction, Andrology, and Gynecology Study Section[CHHD-R]


ORG_CITY: CHAMPAIGN

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE Bioinformatics tools that are easily accessible to experimentalists are required to leverage the large (and rapidly increasing) protein, genome, and metagenome databases to facilitate experimental assignment of functions to uncharacterized proteins discovered in genome projects (in vitro activities and in vivo metabolic/physiological functions). This application requests support for continuation of an NIGMS-developed web resource that provides community access to “genomic enzymology” tools to 1) construct sequence similarity networks for protein families so that sequence-function space can be visualized and analyzed (EFI-EST), 2) generate genome neighborhood networks and genome neighborhood diagrams so that genome context can be used to identify functionally linked proteins in bacteria, archaea, and fungi and propose metabolic pathways (EFI-GNT), and 3) map metagenome abundance to proteins in sequence similarity networks using chemically guided functional profiling so that important targets in microbiome communities can be identified for functional assignment (EFI- CGFP). This resource, developed and disseminated with the support of U54GM093342 and P01GM118303, has been cited in >300 publications and patents, confirming its ease-of-use, popularity, and impact.

PI_NAMEs: GERLT, JOHN A (contact);MITCHELL, DOUGLAS ALAN

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Amino Acid Sequence;Amino Acid Sequence Databases;Archaea;Archaeal Proteins;Archives;Bacteria;Bacterial Proteins;Biochemical;Bioinformatics;bioinformatics tool;biophysical properties;candidate identification;Chemicals;Color;Communities;computer infrastructure;computer program;Data Set;Databases;Democracy;Development;Disease;Environment;Enzymatic Biochemistry;Enzymes;European;Expressed Sequence Tags;Family;Fungal Proteins;fungus;Genes;Genetic Transcription;Genome;genome analysis;genome database;genome resource;Genomics;Guilt;Human Microbiome;improved;in vitro activity;in vivo;Individual;interest;International;Intestines;Knowledge;Legal patent;link protein;Maps;Metabolic;Metabolic Pathway;metagenome;Metagenomics;metatranscriptome;microbial;microbiome;National Institute of General Medical Sciences;Natural Products;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;novel;Nucleotides;Occupations;online resource;Ontology;Pharmacologic Substance;Physiological;Pregnancy;Protein Family;Proteins;prototype;Publications;Request for Applications;Resources;response;Running;screening;Sequence Analysis;small molecule libraries;Surveys;Systems Biology;tool;Visualization

PROJECT_TITLE: Web-Based Resource for Genomic Enzymology Tools


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Prevention

ORG_CITY: Chicago

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: NARRATIVE The project will quantify both healthy and deteriorated cerebral metabolic function in order to precisely correlate biological conditions with age and Alzheimer-related decline. As the main thrust, a computational framework, fully validated by advanced imaging at the cellular level, will be created for translating research data acquired in animal models to human. This computational platform will remove the guesswork from the interpretation of findings obtained in mouse as they relate to aging in humans, ultimately leading to the ability to accurately monitor, diagnose, and treat metabolic disorders causing decline.

PI_NAMEs: LINNINGER, ANDREAS A (contact)

PROGRAM_OFFICER_NAME: NEWMAN, ELIZABETH

PROJECT_TERMS: Address;Affect;Age;age effect;age related;age related deterioration;age related neurodegeneration;aged;Aging;aging biomarker;aging brain;aging population;aging process;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease risk;Alzheimer’s disease biomarker;Anatomy;animal data;Animal Experimentation;Animal Model;Area;Biological;Biological Markers;biomarker identification;Biophysics;Blood capillaries;Blood flow;Blood Vessels;Brain;Cellular Stress;cerebral hemodynamics;cerebrovascular;Cerebrovascular Circulation;cerebrovascular pathology;Cerebrum;Circulation;Clinical;Cognitive;cohort;computational platform;computer framework;Computer Simulation;Core-Binding Factor;Data;Deterioration;Diagnosis;Diagnostic Imaging;digital;Disease;Disease Progression;early detection biomarkers;Early Diagnosis;Endothelium;Event;Exhibits;experimental study;Functional disorder;Future;Goals;Health;Hemodynamic Processes;hemodynamics;Heterogeneity;Homeostasis;Human;human data;human disease;Image;imaging biomarker;Immune;Impaired cognition;improved;Induced Neurons;Infarction;insight;Intervention;Kinetics;Lead;Length;Leukocytes;Link;Magnetic Resonance Imaging;Maps;mathematical methods;Mathematics;Measures;Mediating;Medicine;Metabolic;Metabolic Diseases;Metabolism;Methods;Microcirculation;Microscopic;microscopic imaging;Microvascular Dysfunction;Modeling;models and simulation;Monitor;morphometry;multi-scale modeling;Mus;Nerve Degeneration;network models;neuroimaging;Neurologic;neuron loss;noninvasive diagnosis;novel;Outcome;Oxygen;Pathologic;Pattern;Perfusion;pharmacologic;Physiological;Physiological Processes;predictive modeling;Predictive Value;Predisposition;Process;prodromal Alzheimer's disease;Property;Protocols documentation;Research;Resources;Risk;Rodent;Signal Transduction;simulation;solute;spatiotemporal;Specificity;Symptoms;Techniques;Testing;theories;Time;tissue oxygenation;Tissues;Tracer;Translating;Translations;Validation;Vascular blood supply

PROJECT_TITLE: Image-based cerebrovascular network snythesis(iCNS) to model Alzheimer's Disease

STUDY_SECTION: MABS

STUDY_SECTION_NAME: Modeling and Analysis of Biological Systems Study Section[MABS]


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Disability Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE The health of US working-age adults has declined in recent years, leading to a greater risk of disability and dementia, which imposes substantial challenges to the long-term healthcare system. Determining the mechanisms behind the worsening health among US working-age adults is critically important and timely. Findings from the study will address this urgent public health agenda by clarifying socioeconomic, built, and institutional factors for geographic variation in midlife disability and cognitive function. 1

PI_NAMEs: CHOI, HWAJUNG  (contact)

PROGRAM_OFFICER_NAME: KARRAKER, AMELIA WILKES

PROJECT_TERMS: Address;Adult;Affect;Age;aged;Aging;Area;built environment;Characteristics;Childhood;Cognitive;cognitive function;Communities;comparative;contextual factors;Country;County;Data;data harmonization;Data Protection;Dementia;disability;disability risk;Disadvantaged;disparity reduction;Economic Factors;Economics;England;Europe;European;Exposure to;Family;geographic difference;Geographic Factor;Geographic Locations;Geography;Goals;Health;Health and Retirement Study;health data;health disparity;Health Food;Health Policy;Health Status;Health Surveys;Healthcare;Healthcare Systems;improved;Income;Individual;Inequality;Institution;intervention program;Life;Life Cycle Stages;Life Expectancy;life history;Link;Location;Longitudinal Studies;low socioeconomic status;Marketing;Methods;middle age;mortality;Neighborhoods;novel;Outcome;peer;Policies;Population;population health;Positioning Attribute;Procedures;programs;Public Health;Quasi-experiment;Recording of previous events;Resources;Retirement;Risk;Role;safety net;social;Social Policies;Social Protection;social vulnerability;Socioeconomic Status;socioeconomics;stressor;Surveys;trend;Variant;walkability

PROJECT_TITLE: Implications of residential location in midlife disability and cognitive functioning among the poor vs. rich: within the US and cross-country comparisons


NIH_SPENDING_CATS: Biotechnology;Cancer;Lung;Lung Cancer;Orphan Drug;Rare Diseases

ORG_DEPT: PATHOLOGY

PHR: Project Narrative We plan to discover small molecule inhibitors of the NSD3 protein by high throughput screening (HTS). Activity and mechanism of action of these compounds will be extensively tested in lung cancer cell lines.

PI_NAMEs: GREMBECKA, JOLANTA  (contact)

PROGRAM_OFFICER_NAME: FORRY, SUZANNE L

PROJECT_TERMS: Affinity;analog;Animal Model;Binding;Biochemical;Biological Assay;Biology;biophysical techniques;Biophysics;Bladder;Breast;cancer cell;Cancer cell line;Cancer Model;Cancer Patient;Cell Line;Cells;Chemicals;Clinical;Clinical Research;Clinical Trials;Complex;Development;Dose;drug discovery;druggable target;experimental study;EZH2 gene;Family member;Fluorescein;Fluorescence Polarization;Follicular Lymphoma;Future;Genetic study;Genomics;Goals;Head and neck structure;high throughput screening;histone methyltransferase;Histones;human disease;In Vitro;in vivo;inhibitor;Label;Libraries;Link;Lung;lung cancer cell;Lysine;Malignant Breast Neoplasm;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammalian Cell;Measures;member;Menin;meter;Michigan;Non-Small-Cell Lung Carcinoma;novel anticancer drug;novel therapeutics;Nuclear Family;Nuclear Receptors;Nuclear Structure;Oncogenes;Oncogenic;Osteosarcoma;Outcome;overexpression;Pancreas;Patients;Play;Protein Family;Proteins;receptor binding;Reporting;Role;Sarcoma;screening;Series;SET Domain;small molecule;small molecule inhibitor;small molecule libraries;Squamous Cell Lung Carcinoma;Structure-Activity Relationship;Tertiary Protein Structure;Testing;Therapeutic;Transcriptional Activation;tumorigenesis;Universities

PROJECT_TITLE: Screening for inhibitors of NSD3 as a treatment for lung cancer

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BST-W(55)R]


ADMINISTERING_IC: OD

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Project Narrative The microscopic roundworm C. elegans is used by hundreds of laboratories to understand fundamental biomedical processes. The usefulness of C. elegans stems partly through its well-described anatomy. The Center of C. elegans Anatomy serves the research community by providing extensive tools for the interpretation of C. elegans anatomy, thereby facilitating new discovery with this important model organism.

PI_NAMEs: HALL, DAVID H. (contact);SCHROEDER, NATHAN

PROGRAM_OFFICER_NAME: ZOU, SIGE

PROJECT_TERMS: Adult;Anatomy;Animals;Archives;Atlases;Biomedical Research;Caenorhabditis elegans;Cellular biology;Collaborations;Collection;Colon;Communication;Communities;Data;Data Set;data standards;data visualization;Databases;Development;digital;Educational workshop;Electron Microscopy;Electrons;Ensure;Feedback;Genetic;Genome;Goals;graduate student;Grant;Grant Review;handbook;Illinois;image archival system;improved;in vivo;Individual;Investigation;Knowledge;Laboratories;Letters;Libraries;Life;Light;Machine Learning;Maps;Methods;Microscopic;microscopic imaging;Microtomy;model development;model organism;Modeling;Modernization;Molecular Genetics;Nematoda;Neuroglia;Neurons;Online Systems;Organelles;Parasitology;Photography;Postdoctoral Fellow;Printing;Process;public database;Publications;Publishing;Research;Research Personnel;Resolution;Resources;response;Services;Site;Source;Specimen;stem;Structure;Students;Supercomputing;Surveys;Techniques;Technology;Testing;Text;three-dimensional modeling;Tissues;tool;Training;United States National Institutes of Health;Universities;user-friendly;Visit;Visualization software;web site;Work

PROJECT_TITLE: Center for C elegans Anatomy


ORG_CITY: Boulder

ORG_NAME: UNIVERSITY OF COLORADO

ORG_STATE: CO

PHR: NARRATIVE This research program focuses on lipid signaling pathways controlled by ubiquitous PI3K lipid kinase enzymes. PI3K lipid signaling pathways play central roles in normal macrophage function during innate immunity and, when dysregulated, trigger an array of human diseases. Research is pursuing the molecular mechanisms of regulation in the normal pathway, as well as the mechanisms of dysregulation triggered by disease-linked mu- tations, and the mechanisms by which drugs and potential therapeutics drive pathway activation or inhibition.

PI_NAMEs: FALKE, JOSEPH J (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Actins;Address;Autoimmunity;Biology;cell growth;cell motility;Cell Physiology;Cells;cellular imaging;Chemotaxis;Communities;Complex;Defect;developmental disease;Disease;Enzymes;GTP-Binding Proteins;human disease;imaging study;In Vitro;Infection;Inflammation;innovation;Laboratories;Leadership;Link;Lipid Bilayers;Lipids;live cell imaging;Macrophage;Malignant Neoplasms;Medicine;Membrane;Methods;Modeling;Molecular;Mutation;Natural Immunity;Output;pathogen;Pathway interactions;Phagocytosis;Phagosomes;Pharmaceutical Preparations;Phosphorylation;Phosphotransferases;Physiological;PIK3CG gene;Play;Positioning Attribute;Production;programs;Protein Kinase;Reaction;Reactive Oxygen Species;receptor;reconstitution;Regulation;Research;Role;sensor;Signal Pathway;Signal Transduction;single molecule;Site;Surface;Targeted Research;Testing;Therapeutic;Tissues;Universities

PROJECT_TITLE: Mechanisms of Signaling on Membrane Surfaces

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: PROJECT NARRATIVE The most aggressive form of CRC shows a microsatellite stable phenotype and is characterized by a strong reactive desmoplastic stroma and immunosuppressed microenvironment and can evolve from either serrated or conventional pathways. This type of intestinal cancer, from now on termed mesenchymal CRC, is enriched in a transcriptomic CMS4 signature, displays the poorest prognosis, and lacks effective treatments. Here we will establish the role and mechanism of action of a new metabolic addiction in this type of cancer by testing the hypothesis that PKC/ restrains mesenchymal CRC tumorigenesis by inhibiting the cholesterol biosynthetic pathway through the regulation of SREBP2, the master regulator of cholesterol homeostasis.

PI_NAMEs: MOSCAT, JORGE  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: addiction;Affect;Alanine;cancer initiation;cancer type;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;clinically relevant;colon cancer patients;Colorectal Cancer;Complex;Data;Data Set;design;Desmoplastic;Diet;Diet Modification;effective therapy;Epithelial Cells;Event;experimental study;feeding;Foundations;Generations;Genes;Genetic Transcription;Goals;Golgi Apparatus;Human;human disease;Immunologic Surveillance;immunosuppressed;Immunosuppression;in vivo;Intervention;Intestinal Cancer;intestinal epithelium;Intestinal Neoplasms;Knock-out;KRAS2 gene;Lesion;Mediating;Mesenchymal;Metabolic;Microsatellite Repeats;Modeling;Molecular;mouse model;Mus;mutant;novel;novel therapeutics;Organoids;Pathway interactions;Patients;pharmacologic;Phenotype;Phosphorylation;premalignant;prevent;Prognosis;Protein Kinase;Publishing;Regulation;Repression;restraint;Role;Route;Sampling;Specimen;targeted treatment;Testing;The Cancer Genome Atlas;Therapeutic;TP53 gene;transcriptomics;tumor;tumor initiation;tumor progression;tumorigenesis;Up-Regulation

PROJECT_TITLE: Cholesterol metabolism in mesenchymal colorectal cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: WALTHAM

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BRANDEIS UNIVERSITY

PHR: Project Narrative Relevance: Neural interactions between the hippocampus and prefrontal cortex are critical for learning and memory-guided behavior, and dysfunction in these networks is implicated in numerous memory disorders such as dementia and Alzhiemer’s disease, as well as in neuropsychiatric disorders such as autism and schizophrenia. This proposal aims to use novel methods to monitor neural activity and inter-regional coordination during behavior in order to provide an integrated understanding of the role of prominent neurophysiological activity patterns that support our ability to learn, form memories and guide decisions. This project will thus provide crucial insight into neural mechanisms that underlie fundamental cognitive abilities, and contribute to an understanding of the pathophysiology of cognitive dysfunction in numerous disorders.

PI_NAMEs: JADHAV, SHANTANU P (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Address;Affect;Aging;Alzheimer's Disease;autism spectrum disorder;Automobile Driving;awake;Behavior;Behavioral;cell assembly;Cells;Code;cognitive ability;cognitive process;Complex;Data;Decision Making;Dementia;density;Disease;Dopamine;Dopaminergic Cell;dopaminergic neuron;Event;experience;Exploratory Behavior;flexibility;Functional disorder;Future;Goals;Hippocampus;Immobilization;Impaired cognition;insight;Interruption;Learning;Link;Location;Maintenance;Maps;Medial;Mediating;Memory;memory consolidation;Memory Disorders;memory process;Methods;Monitor;Nature;neural;neuromechanism;Neurons;neurophysiology;neuropsychiatric disorder;novel;optogenetics;Pattern;Physiological;Play;Prefrontal Cortex;Psychological reinforcement;Rattus;Retrieval;Rewards;Rodent;Role;Schizophrenia;Signal Transduction;Sleep;Testing;Ventral Tegmental Area

PROJECT_TITLE: Role of physiological patterns in hippocampal-prefrontal interactions

STUDY_SECTION: LMDN

STUDY_SECTION_NAME: Learning, Memory and Decision Neuroscience Study Section[LMDN]


ORG_CITY: BOSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: PROJECT NARRATIVE The synthesis pathway for the bacterial cell wall is the target of many of our best antibiotics, including penicillin and vancomycin. The focus of this research proposal is to elucidate the molecular mechanisms by which the major cell wall assembly machineries build the wall and promote cell division in rod-shaped bacteria. The results will help us learn new ways of targeting these machineries for the development of novel classes of antibiotics to combat the growing problem of drug resistant infections.

PI_NAMEs: BERNHARDT, THOMAS G (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Actins;Address;Anti-Bacterial Agents;Antibiotics;Area;Bacillus;Bacteria;Biochemical;Biogenesis;Biological;cell assembly;Cell division;cell envelope;cell growth;Cell membrane;Cell model;Cell Physiology;Cell Shape;Cell Wall;Cells;Cellular biology;Collection;combat;Complex;Coupled;crosslink;Cues;Cytolysis;Cytoskeletal Modeling;Cytoskeleton;daughter cell;Development;Drug resistance;Enzymes;Escherichia coli;experimental study;Foundations;Genetic;genetic analysis;Genetic study;Goals;Gram-Negative Bacteria;Growth;Health;Human;Hyperactivity;in vitro activity;Infection;Knowledge;Learning;Membrane Proteins;Methods;Microfilaments;Molecular;Monitor;Morphogenesis;mutant;novel antibiotic class;Organism;Osmosis;Pathway interactions;Penicillin-Binding Proteins;Penicillins;Peptides;Peptidoglycan;Pharmaceutical Preparations;Physiological;Polymerase;Polysaccharides;prevent;Process;Protein Family;protein function;Proteins;Pseudomonas aeruginosa;Research Proposals;response;Rod;Role;Shapes;skills;Structure;synthetic enzyme;System;targeted agent;Tubulin;Vancomycin;Variant;Work

PROJECT_TITLE: Peptidoglycan Biogenesis in Escherichia Coli

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Regenerative Medicine

ORG_CITY: STANFORD

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Optic nerve damage and retinal ganglion cell loss is common to many eye diseases, including glaucoma and ischemic optic neuropathies. There are, however, no therapies that specifically promote retinal ganglion cell survival or axon regeneration in these diseases. A better understanding of the cellular mechanisms that impact neuroprotection and axonal regeneration may yield better therapeutic regimens, decreasing morbidity and potentially restoring vision.

PI_NAMEs: GOLDBERG, JEFFREY L;KAPILOFF, MICHAEL SETH (contact)

PROGRAM_OFFICER_NAME: FORTRESS, ASHLEY

PROJECT_TERMS: A kinase anchoring protein;Adenylate Cyclase;analog;Area;axon regeneration;Biological Assay;Blindness;Brain-Derived Neurotrophic Factor;Candidate Disease Gene;Catalytic Domain;Cell Death;Cell membrane;cell regeneration;Cell Survival;Cells;cellular resilience;Cessation of life;Chimeric Proteins;Chronic;Complete Blindness;Crush Injury;Cyclic AMP;Cytosol;Data;Dependovirus;design;Disease;experimental study;Eye diseases;gain of function;Gene Expression;Gene Transduction Agent;Generations;Genes;Genetic Transcription;Glaucoma;in vivo;Individual;Injury;insight;Intervention;Investigation;Ischemic Optic Neuropathy;loss of function;MAPK3 gene;Mediating;Mediator;Mitogen-Activated Protein Kinases;Modeling;Molecular;Morbidity - disease rate;Mus;Muscle Proteins;Natural regeneration;Nerve Crush;nerve damage;neuroprotection;neurotrophic factor;Nuclear;Nuclear Envelope;Nuclear Matrix-Associated Proteins;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Pathway interactions;PDE4D3;phosphoric diester hydrolase;Predisposition;preservation;prevent;programs;protein activation;protein expression;Proteins;regenerative;Regimen;Regulation;Regulatory Pathway;response;Retinal Ganglion Cells;RNA;Role;sight restoration;Signal Pathway;Signal Transduction;Signal Transduction Pathway;single-cell RNA sequencing;Specificity;synergism;Testing;Therapeutic;Therapeutic Intervention;tool;transcription factor;transcriptome sequencing

PROJECT_TITLE: Gene Expression Regulatory Pathways and Retinal Ganglion Cell Neuroprotection


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Basic Behavioral and Social Science;Behavioral and Social Science;Lupus;Mental Health;Social Determinants of Health

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE How increased psychosocial stress worsens outcomes in patients with systemic lupus erythematosus (SLE) is poorly understood. We propose to test the role of a newly-discovered pathway that mechanistically links psychosocial stress and immunometabolic reprogramming in mediating the impacts of psychosocial stress on SLE pathogenesis.

PI_NAMEs: WANG, ANDREW  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Acute;acute stress;Adipocytes;Adrenal Glands;Adverse effects;Agonist;Animal Housing;Animals;antagonist;Antibodies;Antibody Response;Autoantibodies;Autoimmune Diseases;Autoimmunity;B-Lymphocytes;Biological;Biological Assay;Body Temperature;Brain;Catecholamines;Cells;Chronic;Chronic stress;comparison control;Confusion;Data;Development;Disease;Disease Outcome;environmental enrichment for laboratory animals;Event;fighting;Flare;Genetic;genetic approach;Glucocorticoids;Glucose;glucose metabolism;Goals;Helper-Inducer T-Lymphocyte;Hepatic;hepatic gluconeogenesis;Hepatocyte;House mice;Housing;Human;IL6 gene;Immune;immune activation;Immunity;improved;Inflammatory Response;insight;Laboratory mice;Life Stress;Link;Lupus;Mediating;Metabolic;Methods;Modeling;mortality;mouse model;Mus;Myeloid Cell Activation;neurotransmission;novel;Operative Surgical Procedures;Outcome;Pathogenesis;Pathway interactions;Patients;perceived stress;pharmacologic;Physiologic Thermoregulation;plasma cell differentiation;Play;pre-clinical;Production;Proteinuria;prototype;psychosocial;Psychosocial Stress;psychosocial stressors;Receptors, Adrenergic, beta-3;renal damage;Renal function;Reporting;response;rheumatologist;Role;Signal Transduction;Source;Stress;Systemic Lupus Erythematosus;Temperature;Testing;Thermogenesis;Translations

PROJECT_TITLE: The Role of the Adrb3/IL6 Axis in the Impact of Psychosocial Stress on Lupus Pathogenesis

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Arthritis;Bioengineering;Osteoarthritis;Physical Injury - Accidents and Adverse Effects

ORG_CITY: DAVIS

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Traumatic joint injuries such as anterior cruciate ligament (ACL) rupture often lead to post-traumatic osteoarthritis (PTOA) within 10-20 years following an injury. Joint loading (exercise/walking) or unloading (rest/disuse) in the early stages following injury may affect the development of PTOA, but there is currently no clinical consensus on recommendations for activity during this time frame. In the proposed studies, we will investigate how unloading of an injured joint can affect the development of PTOA. We will also investigate biomechanical interventions aimed at preserving bone and muscle during unloading and restoring stability of the joint, and determine the effect of these interventions on PTOA progression. Results from these studies may lead to the development of post-injury therapeutic strategies for preserving long-term joint health of patients following injury.

PI_NAMEs: CHRISTIANSEN, BLAINE A. (contact)

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Affect;anterior cruciate ligament injury;anterior cruciate ligament rupture;Arthralgia;articular cartilage;Articular Range of Motion;Atrophic;Biological Response Modifier Therapy;Biomechanics;bone;bone preservation;Bone Resorption;Bone Spur;Bone structure;cartilage degradation;Catabolic Process;Cell Death;Clinical;Clinical Research;clinically relevant;Consensus;Data;Development;Disease;Exercise;Gait;Goals;Health;Hindlimb Suspension;Hour;Individual;Inflammation;Inflammation Process;Inflammatory;injured;Injury;insight;Intervention;intervention effect;joint destruction;joint injury;Joint Laxity;joint loading;Joints;Knee;Life;limb injury;Mechanics;Modeling;Moderate Activity;Modification;Mus;Muscle;muscle form;muscle strength;Muscular Atrophy;Operative Surgical Procedures;Outcome;Pain management;Patients;Peptide Hydrolases;Persons;Phase;Population;preservation;prevent;Process;Recommendation;rehabilitation strategy;repaired;Replacement Arthroplasty;Research;Rest;sham surgery;Structure;subchondral bone;Therapeutic;Time;Traumatic Arthropathy;treatment strategy;Walking

PROJECT_TITLE: Modification of Post-Traumatic Osteoarthritis Progression with Joint Unloading

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Digestive Diseases;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Pancreatic Cancer;Rare Diseases

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Project Narrative Pancreatic cancer is one of the most lethal human cancers, with fewer than 5% of the patients surviving beyond 5 years following diagnosis. This proposal seeks to develop a novel mRNA- LNP-based immunotherapy to stimulate antitumor immunity against pancreatic cancer. We will also combine our approach with immune checkpoint inhibitors to achieve synergistic anticancer efficacy.

PI_NAMEs: YOU, JIANXIN  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: advanced pancreatic cancer;Agonist;anti-cancer;anti-PD1 antibodies;Antibody Therapy;Antigen-Presenting Cells;Antitumor Response;autoinflammatory diseases;Biological Assay;Biological Response Modifiers;cancer cell;cancer immunotherapy;CD8-Positive T-Lymphocytes;cell killing;checkpoint therapy;chemokine;Chemotactic Factors;Clinical;Collaborations;COVID-19 vaccine;cytokine;cytotoxicity;Development;Diagnosis;effective therapy;Effectiveness;engineered T cells;Engineering;Face;gene function;gene repression;Gene Silencing;gene therapy;Goals;Grant;Human;Hyperactivity;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;immune resistance;Immune system;immunogenicity;Immunologics;Immunosuppression;Immunotherapy;implantation;improved;In Vitro;in vitro testing;in vivo;Infiltration;Legal patent;Letters;Link;lipid nanoparticle;Malignant neoplasm of pancreas;Malignant Neoplasms;Messenger RNA;Methods;migration;mRNA Expression;multidisciplinary;Mus;mutant;neoplastic cell;new therapeutic target;novel;novel therapeutic intervention;Pancreas;pancreatic cancer model;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;pancreatic ductal adenocarcinoma model;Patients;PD-1 blockade;PD-1/PD-L1;Peptides;preclinical study;prevent;Production;Publishing;refractory cancer;Repression;Resistance;RNA;Stimulator of Interferon Genes;success;synergism;T cell infiltration;T cell response;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic nanoparticles;Tissues;Toxic effect;Translating;Treatment outcome;tumor;Tumor Antigens;tumor DNA;Tumor Immunity;tumor microenvironment;tumor specificity;tumor-immune system interactions;ultrasound;Work

PROJECT_TITLE: A novel gene therapy approach targeting STING-silenced cold tumors


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Bioengineering;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

PHR: PROJECT NARRATIVE High-throughput single-cell imaging requires tools to easily select subpopulations. We will develop three techniques to automate annotation of individual cells that include reading annotation directly from the image, creating models to predict correct annotation, and identifying features that uniquely barcode the same cell across multiple images. Ease of annotation will allow us to study specific sub-populations and applying machine intelligence to datasets.

PI_NAMEs: FINKBEINER, STEVEN M (contact)

PROGRAM_OFFICER_NAME: DENNIS, ALLISON FRANCES

PROJECT_TERMS: Acceleration;Address;algorithm development;Algorithms;Anatomy;Animal Model;Artificial Intelligence;Automated Annotation;Bar Codes;Basic Science;Bioinformatics;Biological;Biological Markers;biomedical informatics;Biomedical Research;Brain;cell behavior;cell motility;Cell Separation;cell type;Cells;Cellular biology;cellular imaging;Central Nervous System Diseases;Characteristics;Chemicals;Classification;Collection;Communities;Complex;Complex Mixtures;computerized tools;Computers;Computing Methodologies;Consumption;cost;Cultured Cells;Data;Data Analyses;data curation;data repository;Data Science;Data Set;Detection;experimental study;fluorescence imaging;Foundations;Genomics;Goals;Human;Image;image processing;Imaging Device;Imaging technology;Immobilization;improved;in silico;Individual;interest;Intervention;Investigation;Label;large datasets;Learning;Letters;Link;Machine Learning;Manuals;Measurement;meetings;Memory;Microscope;Microscopy;Modeling;Monitor;Morphology;Nerve Degeneration;Neurites;Neurons;Neurosciences;next generation;Nightmare;Ownership;Phenotype;Physiology;Proteomics;Quality Control;Readability;Reading;repository;Research;Research Personnel;Research Project Grants;Resolution;response;robotic microscopy;Sampling;screening;Slice;Specific qualifier value;Stimulus;synaptogenesis;Techniques;Technology;Testing;Time;Tissues;tool;Transfection;United States National Library of Medicine;Validation;Variant;Work

PROJECT_TITLE: Image Tools for Computational Cellular Barcoding and Automated Annotation

STUDY_SECTION: BLR

STUDY_SECTION_NAME: Biomedical Informatics, Library and Data Sciences Review Committee[BLR]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: KANSAS CITY

ORG_NAME: STOWERS INSTITUTE FOR MEDICAL RESEARCH

ORG_STATE: MO

PHR: Project Narrative  The function of genes is usually determined after disrupting its DNA sequence. However, there are a several advantages of reducing the RNA level (knockdown) and keeping the DNA intact. In aquatic vertebrates such as zebrafish, there was not a systematic tool to knockdown mRNA. We have recently demonstrated a new technology (CRISPR-RfxCas13d) to knockdown gene expression in vertebrate embryos. We plan to generate transgenic strains (CRISPR-RfxCas13d) to discover gene function in the zebrafish embryo in a faster, tractable, and tissue-temporal-dependent manner.

PI_NAMEs: BAZZINI, ARIEL  (contact)

PROGRAM_OFFICER_NAME: CONTRERAS, MIGUEL A

PROJECT_TERMS: Address;Alternative Splicing;Animal Model;Base Sequence;Biological;Biological Models;Biological Process;Chronic;Clustered Regularly Interspaced Short Palindromic Repeats;Codon Nucleotides;Collection;Communities;Complex;Consumption;cost effective;cost efficient;CRISPR/Cas technology;Data;Development;Disease;DNA;DNA Sequence;Effectiveness;Embryo;Endoribonucleases;Enzymes;Essential Genes;Exons;Foundations;Free Will;gene discovery;Gene Expression;gene function;Gene Mutation;Gene Transfer Techniques;Genes;Genetic Transcription;genome editing;Genome engineering;Genomic DNA;genomic locus;Genotype;Goals;Guide RNA;Guidelines;human disease;In Situ Hybridization;Incidence;Individual;Injections;innovation;Investigation;Killifishes;knock-down;Knock-out;knockout gene;Link;Masks;Messenger RNA;Methodology;Methods;model organism;mRNA Expression;Mus;mutant;new technology;novel;Nuclear Localization Signal;Organism;Oryziinae;Outcome;Phenotype;promoter;Publications;Reagent;Research;Research Personnel;Reverse Transcriptase Polymerase Chain Reaction;RNA;RNA Degradation;RNA Interference;Role;scaffold;Series;Specificity;System;Techniques;Technology;teleost fish;Testing;Time;Tissues;tool;transcriptome sequencing;transgene expression;Transgenic Organisms;Untranslated RNA;Validation;Variant;vertebrate embryos;Vertebrates;Western Blotting;Work;Xenopus;Zebrafish

PROJECT_TITLE: CRISPR-Cas13d: Transgenic zebrafish lines toknockdown mRNA

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: Project Narrative The overarching goal of our research program is to identify novel cytoprotective genes and mechanisms that protect cells against oxidative, metabolic and hypoxic/ischemic stresses using diverse and complementary model systems. The outcome of our research program may help advance our basic understanding of principles for cell physiological homeostasis and adaptation to stress, as well as develop biomedical applications in therapeutic hypothermia and new treatments for metabolic, neurological and ischemic disorders.

PI_NAMEs: MA, DENGKE  (contact)

PROJECT_TERMS: Abnormal Cell;Address;Behavior;behavioral phenotyping;Biochemical Process;Biological Models;Brain Hypoxia-Ischemia;Caenorhabditis elegans;California;Cardiovascular system;Cells;cold temperature;coping;Cytoprotection;Dedications;Disease;Disparate;Equilibrium;experience;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Screening;Goals;Homeostasis;Hypoxia;innovation;interdisciplinary approach;interest;Ischemia;Killifishes;Laboratories;Life;Metabolic;Metabolic stress;Metabolism;mutant;Myocardial Infarction;National Institute of General Medical Sciences;natural hypothermia;nerve stem cell;Neurologic;novel;Organism;Outcome;Oxidative Stress;Oxygen;Pathway interactions;Phenotype;Physiological;Physiological Adaptation;Physiology;Productivity;programs;Proteins;Research;Research Institute;resilience;Resources;response;RNA interference screen;Running;San Francisco;Self-Fertilizations;Spermophilus;Stress;Stroke;Technology;Temperature;Therapeutic;Therapeutic procedure;tissue injury;tool;Universities;Variant

PROJECT_TITLE: Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Hearing Loss;Neurosciences;Patient Safety;Prevention;Rehabilitation

ORG_CITY: CORAL GABLES

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: Public health relevance: Cochlear implantation surgery results in inflammation, mechanical and vascular damage and loss of sensory hair cells and neurons. This research is focused on designing safe and effective devices and protocols to deliver therapeutic hypothermia to the inner ear. The proposed studies will lead to major advancements that benefit patients undergoing cochlear implantation, as well as those exposed cisplatin-induced ototoxicity and various head and neck surgeries.

PI_NAMEs: RAJGURU, SUHRUD M. (contact)

PROGRAM_OFFICER_NAME: MILLER, ROGER

PROJECT_TERMS: Acoustics;Acute;Address;Affect;Age;Apoptosis;Audiology;Auditory;Auditory area;Auditory Brainstem Responses;Biological;Blood;Blood Vessels;Cadaver;Caspase;Cell Count;Cell Death;Cell Physiology;Cell Survival;Child;Cisplatin;Clinical;clinical application;Clinical Protocols;clinical translation;Cochlea;Cochlear implant procedure;Cochlear Implants;Custom;cytokine;Data;design;Deterioration;Development;Devices;effective therapy;Electric Stimulation;Elements;Eligibility Determination;Ensure;experimental study;Face;Fibrosis;Functional disorder;functional improvement;Future;Gender;Gene Expression;Hair Cells;Head and Neck Surgery;Hearing;hearing impairment;hearing preservation;Histologic;Homeostasis;Human;Hypoxia;Immunohistochemistry;Implant;implantation;improved;induced hypothermia;industry partner;Inflammation;Inflammatory;Inhibition of Apoptosis;Injury;Intervention;Ischemia;ischemic injury;Knowledge;Labyrinth;Link;Maintenance;Marketing;Measurement;Measures;Mechanics;Mediating;Modality;Modeling;Molecular;Molecular Biology;natural hypothermia;neural;Neurons;neuroprotection;next generation;Noise;Operating Rooms;Operative Surgical Procedures;Organ of Corti;otoacoustic emission;ototoxicity;Outcome;Oxidative Stress;Pathway interactions;Patients;Pharmacologic Substance;Physiologic Ossification;Physiological;postsynaptic;pre-clinical;Pre-Clinical Model;preservation;presynaptic;Procedures;protective effect;Protocols documentation;public health relevance;Publishing;Reaction;Regimen;Reperfusion Injury;Research;Residual state;Reverse Transcriptase Polymerase Chain Reaction;Rewarming;round window;Safety;safety testing;Sensorineural Hearing Loss;Sensory Hair;Signal Pathway;Speech Perception;spiral ganglion;standard of care;Stria Vascularis;Structure;Synapses;System;Techniques;technological innovation;Technology;Temperature;Temporal bone structure;Testing;Therapeutic;Therapeutic Intervention;therapeutically effective;Time;transcriptome sequencing;translational therapeutics;Trauma;Tympanostomy;Vestibular function;vestibular system;Work

PROJECT_TITLE: Application of mild therapeutic hypothermia for hearing conservation during cochlear implant surgeries

STUDY_SECTION: AUD

STUDY_SECTION_NAME: Auditory System Study Section[AUD]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Biotechnology;Gene Therapy;Genetics;Immunotherapy;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: PROJECT NARRATIVE Cell and viral based therapies have the potential to revolutionize the treatment of many diseases. However, the optimization of such biological therapies depends critically on the ability to monitor the spread and persistence of the therapeutic agent and assess the tissue response. This project therefore proposes to develop and optimize a novel MRI reporter gene technology that allows for the imaging of biological therapeutics. The reporter gene technology will be demonstrated for monitoring oncolytic virotherapy in glioblastoma tumor models, however, the technology is generalizable to any biological therapeutic.

PI_NAMEs: FARRAR, CHRISTIAN T (contact);GILAD, ASSAF A

PROGRAM_OFFICER_NAME: ATANASIJEVIC, TATJANA

PROJECT_TERMS: Algorithms;Amides;Artificial Intelligence;Biological Response Modifier Therapy;cancer imaging;Cardiac;Cell Differentiation process;Cells;Chemicals;Clinic;Clinical;Clinical assessments;clinical translation;Collaborations;deep learning;deep neural network;Detection;detection method;detection sensitivity;Development;Diagnosis;Discrimination;Disease;Drug Kinetics;Evolution;Fingerprint;gene therapy;Gene Transfer;Genes;Genetic Programming;Glioblastoma;Goals;Histologic;Image;imaging modality;improved;in vivo imaging;Infection;Longitudinal Studies;Lysine;Machine Learning;Magnetic Resonance;Magnetic Resonance Imaging;Measurement;Medical Imaging;Metabolic;Methods;Modeling;Monitor;Mus;neoplastic cell;neural network architecture;novel;Oncolytic;oncolytic virotherapy;Oncolytic viruses;Pathology;Performance;Physiologic pulse;pre-clinical;Predisposition;Problem Solving;Productivity;Protein Engineering;Proteins;Protons;radio frequency;rapid technique;Reporter;Reporter Genes;Resistance;Resolution;response;Schedule;Sensitivity and Specificity;Signal Transduction;Specificity;Technology;Testing;Therapeutic;Therapeutic Agents;therapeutic gene;Time;Tissues;tool;trafficking;transgene expression;tumor;Tumor Cell Line;Viral;viral gene delivery;Virus Diseases;Virus Replication;Water;Work

PROJECT_TITLE: Artificial Intelligence Boosted Evolution and Detection of Genetically Encoded Reporters for In Vivo Imaging

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


NIH_SPENDING_CATS: Hematology;Wound Healing and Care

ORG_CITY: CINCINNATI

ORG_NAME: UNIVERSITY OF CINCINNATI

PHR: Narrative Burn patients develop anemia and require large amounts of transfused blood in part because of an inflammation mediated impairment of red blood cell production. The goal of this proposal is to understand how inflammation impairs red blood cell production and to identify new treatments that reduce the need for transfusion.

PI_NAMEs: GARDNER, JASON  (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, NITIN

PROJECT_TERMS: access restrictions;Anemia;Attenuated;autocrine;Autocrine Communication;Blood;Blood Transfusion;Blood Vessels;Body Surface Area;Bone Marrow;Burn injury;burn model;Burn Units;burn wound;Caring;cell type;Cells;Characteristics;Clinical;Complication;Critical Illness;CSF3 gene;cytokine;Data;Debridement;Disparate;Elective Surgical Procedures;Erythrocytes;Erythroid Cells;Erythropoiesis;Erythropoietin;Event;Fibroblasts;Genes;Genetic Models;Goals;Hemolysis;hepcidin;Hormones;Human;IL1R1 gene;Impairment;improved;Individual;Infection;Inflammation;Inflammatory;Institution;Insulin-Like Growth Factor I;Interleukin-1 alpha;Interleukin-1 beta;Interleukin-6;Interruption;Intervention;Iron;iron supplement;iron supplementation;Island;Knock-out;life span;Ligands;Macrophage;Maintenance;Mediating;Mediator;Medical;Modeling;Molecular;mortality;Mus;MYD88 deficiency;Myelogenous;neutralizing antibody;novel;Outcome;Pathogenesis;Pathologic;Pathway interactions;Patients;pre-clinical;Production;Protocols documentation;receptor;Red Cell Mass result;Reporter;Resistance;response;Risk Factors;Role;severe burns;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Skin;skin burn;Source;Sterility;Testing;Therapeutic;therapeutic development;tissue injury;TLR2 gene;TLR4 gene;transcriptomics;Transfusion;translational therapeutics;Trauma;wound

PROJECT_TITLE: Inflammatory Mechanisms in Post Burn Anemia of Critical Illness

STUDY_SECTION: SAT

STUDY_SECTION_NAME: Surgery, Anesthesiology and Trauma Study Section[SAT]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

ORG_CITY: NEW YORK

ORG_DEPT: GENETICS

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE Although HIV infection rates have seen reductions with advances in healthcare and therapy, the number of people living with HIV continues to increase. In order to protect the larger populace against HIV infections, a safe and effective vaccine is in urgent demand. The goal of this project is to develop functional nanomaterials capable of effectively delivering mRNAs encoding HIV immunogens as a vaccine candidate.

PI_NAMEs: DONG, YIZHOU  (contact);IRVINE, DARRELL J

PROGRAM_OFFICER_NAME: SINGH, ANJALI

PROJECT_TERMS: 2019-nCoV;3' Untranslated Regions;adaptive immunity;Adjuvant;Affect;Agonist;Animal Model;Animals;Antibodies;Antibody Response;Antibody-mediated protection;Antigens;B-Lymphocytes;Biological Assay;Biological Response Modifiers;CD8-Positive T-Lymphocytes;Cell model;Cells;Cellular Immunity;Charge;Chemicals;Clinical;Clinical Data;Clinical Research;clinical translation;Clinical Trials;Country;COVID-19 vaccine;Cytotoxic T-Lymphocytes;Data;Dendritic Cells;design;Development;emerging pathogen;Engineering;env Gene Products;Epidemic;Epitopes;Europe;Exhibits;experience;Formulation;Future;gag Gene Products;Gene Expression;glycosylation;Goals;health goals;Healthcare;healthcare burden;high volume manufacturing;HIV;HIV Antigens;HIV Infections;HIV vaccine;Human;Humoral Immunities;Immune;Immune response;immunogenicity;in vivo;infection rate;Knowledge;Lead;lipid nanoparticle;Macaca;Mannose Binding Lectin;Mediating;Messenger RNA;Modeling;Moderna COVID-19 vaccine;mouse model;mRNA delivery;Mus;nanomaterials;nanoparticle;Nanotechnology;neutralizing antibody;nonhuman primate;Organ;particle;Pathway interactions;Pattern;Persons;Pfizer-BioNTech COVID-19 vaccine;Polymerase;Population;Post-Translational Protein Processing;pre-clinical;preclinical study;Process;Production;Property;Proteins;Public Health;Recombinants;Regimen;Reporting;Research Personnel;Resistance;RNA;RNA vaccination;RNA vaccine;Safety;side effect;SIV;South Africa;Stimulator of Interferon Genes;Structural Protein;Surface;T cell response;T-Lymphocyte;T-Lymphocyte Epitopes;Technology;technology platform;Thailand;TLR7 gene;Toll-like receptors;Transcript;Translations;Untranslated Regions;Vaccinated;Vaccination;vaccine access;vaccine candidate;Vaccine Design;vaccine development;vaccine discovery;vaccine platform;Vaccines;Viral;Viral Antigens;Virus Diseases

PROJECT_TITLE: Integration of adjuvant derived nanoparticles and engineered mRNA for HIV vaccine discovery

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


NIH_SPENDING_CATS: Genetics

PHR: Project Narrative This project will analyze the functions of chromatin modifying proteins and complexes which when perturbed can lead to the development of cancer and other diseases. Novel functions of these proteins in RNA processing, cellular signaling and metabolism will be investigated in yeast and mammalian cells.

PI_NAMEs: WORKMAN, JERRY L (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: Acetylation;Affect;amino acid metabolism;ARID1A gene;ATP phosphohydrolase;Bromodomain;Cancer cell line;Cell Cycle Progression;Cell Physiology;Cellular Metabolic Process;Chromatin;Chromatin Remodeling Factor;Complex;detection of nutrient;Development;Disease;Gene Activation;Genes;Genetic Transcription;Goals;histone methylation;Histones;Homeostasis;Human;interest;Malignant Neoplasms;Mammalian Cell;Mammals;Metabolism;Methylation;Methyltransferase;Modification;Mutation;novel;Nucleosomes;Oxidation-Reduction;paralogous gene;particle;Pathway interactions;Phospholipid Metabolism;Phosphorylation;Phosphotransferases;Protein Biosynthesis;protein function;Proteins;Recurrence;Regulation;Regulon;response;Ribonucleoproteins;RNA Processing;RNA Splicing;Role;Signal Pathway;Signal Transduction;SMARCA2 gene;SMARCA4 gene;Stress;Sulfur Amino Acids;SWI/SNF Family Complex;Therapeutic;transcription factor;Transcriptional Regulation;Tumor Suppressor Proteins;Yeasts

PROJECT_TITLE: Transcription regulation in chromatin

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


ORG_CITY: GAINESVILLE

ORG_NAME: UNIVERSITY OF FLORIDA

PHR: The highly successful annual International Federation of Placenta Associations (IFPA) meeting serves to bring together clinicians and scientists, established senior, mid-career, and junior investigators from around the world, to report and discuss their findings in an atmosphere conducive to frank yet amicable exchange. In addition, the IFPA meetings include interactive sessions on career development, and networking opportunities. This application seeks funding to cover travel costs to allow the attendance of 8-12 trainees and new investigators from the USA at the annual IFPA meetings together with funding to support the travel costs of a senior US-based investigator to these meetings where he/she will present an invited plenary lecture and take part in workshop sessions.

PI_NAMEs: JONES, HELEN N (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Address;angiogenesis;Apoptosis;Applications Grants;Area;Argentina;Atmosphere;Award;Awards and Prizes;Barker Hypothesis;Canada;Cancer Biology;career;career development;Child;Clinical;Collaborations;Communities;cost;Dedications;Development;Diabetes Mellitus;Discipline;Doctor of Medicine;Doctor of Philosophy;Educational workshop;Endocrinology;Ensure;epigenomics;Europe;Exposure to;Female;Fetal Development;Fetal Growth;Fetal Growth Retardation;Funding;Genomics;Grant;hormonal signals;Hour;Human;Immunology;Individual;International;Investigation;Japan;Knowledge;Learning;lecturer;lectures;meetings;Metabolism;Minority;Mothers;multidisciplinary;Nature;Netherlands;New Zealand;Nutrient;Obesity;Oral;Pathology;Physiological;Placenta;Placental Biology;pleiotropism;posters;Pre-Eclampsia;Pregnancy;Pregnancy loss;premature;programs;Regulation;Reporting;Research;research and development;Research Personnel;Rest;Role;Schedule;Scientist;Secure;Students;symposium;Talents;Technology;Time;Training;Travel;United States National Institutes of Health;Woman;Work

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Machine Learning and Artificial Intelligence;Prevention;Social Determinants of Health

ORG_CITY: BLOOMINGTON

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Interventions, including health communication interventions via social media, are sorely needed to address the lack of pre-exposure prophylaxis (PrEP) awareness and mitigate barriers related to PrEP usage/adherence among young people who bear a disproportionate burden of HIV infection (e.g., young bisexual men, trans women), particularly regarding the potential for social influence, norm setting, and reduction of stigma. This proposed exploratory research project will characterize the social media landscape regarding PrEP and HIV prevention messages and develop new and improved messages about PrEP that are clear, specific, consistent, and scientifically up to date. Together, this knowledge and improved messaging can enhance and target efforts via popular and accessible digital tools and new technologies, such as social media, effectively supporting the updated National HIV/AIDS Strategy for the U.S.

PI_NAMEs: WALSH-BUHI, ERIC RICHARD (contact)

PROGRAM_OFFICER_NAME: MAJJI, SAI PRASANNA

PROJECT_TERMS: 18 year old;Address;Adherence;Adolescent;Adult;aged;AIDS prevention;Anal Sex;analytical method;Area;Awareness;behavior change;Behavioral;Bisexual;black men who have sex with men;Black Populations;Black race;Characteristics;cis-male;Clinic;Clinical Trials;Code;Cohort Studies;Communication;condoms;cost;Couples;design;Development;Diffusion;digital tool;Education;Epidemic;Evaluation;evidence base;Facebook;FDA approved;Future;Gays;gender diverse;Health;health communication;Heterosexuals;HIV;HIV diagnosis;HIV Infections;HIV risk;HIV Seronegativity;HIV/AIDS;Human;human centered design;Human immunodeficiency virus test;improved;Individual;infection burden;Injectable;Injecting drug user;innovation;Instagram;Institution;Intervention;Knowledge;Lesbian;Lesbian Gay Bisexual Transgender Queer;Libraries;machine learning method;medication compliance;men;men who have sex with men;Methods;Modality;Modeling;multidisciplinary;multilevel analysis;new technology;nonbinary;Oral;Persons;pilot test;Population;Populations at Risk;posters;pre-exposure prophylaxis;predictive modeling;Prevention;Prevention strategy;Probability;recruit;Reporting;Research;Research Project Grants;Risk;Sampling;Services;sexual risk reduction;sexually active;social influence;Social Marketing;social media;Social Network;social stigma;Source;study population;Testing;theories;Theory of Change;training data;transgender;transgender women;Twitter;Update;uptake;Youth

PROJECT_TITLE: Pre-exposure prophylaxis (PrEP) information on social media

STUDY_SECTION: HIBI

STUDY_SECTION_NAME: HIV/AIDS Intra- and Inter-personal Determinants and Behavioral Interventions Study Section[HIBI]


ADMINISTERING_IC: VA

FUNDING_MECHANISM: OTHERS

IC_NAME: Veterans Affairs

ORG_CITY: DURHAM

ORG_NAME: DURHAM VA MEDICAL CENTER

ORG_STATE: NC

PHR: Veterans living with dementia and their caregivers frequently visit the Emergency Department (ED), so it is es- sential that they be able to make informed decisions about their care. One of the most critical choices during an ED visit is the decision to be admitted to the hospital or to be discharged home. This decision is especially difficult when ED testing has not found a clear reason for admission, and the need for hospitalization for further testing or monitoring is unclear. However, there are significant risks associated with either choice, such as hospital- acquired infections when admitted, or return ED visits when discharged. This research project seeks to develop a shared decision making tool that will help Veterans living with dementia, their caregivers, and ED health care providers have conversations about risks, benefits and what matters most, in order to make a disposition decision that is aligned with patient and caregiver values and preferences. This work will ultimately improve the delivery of high-quality ED care for Veterans with dementia and their caregivers.

PI_NAMEs: SEIDENFELD, JUSTINE  (contact)

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Acute;Admission activity;Age;Alzheimer's Disease;Alzheimer's disease related dementia;Area;Award;care coordination;care delivery;career;career development;Caregivers;Caring;Characteristics;Clinical;cohort;Collaborations;Communities;comorbidity;Complex;cost;Data;Decision Aid;Delirium;Dementia;Dementia caregivers;design;Development;Diagnosis;Effectiveness;Elements;Emergency Care;Emergency department visit;Emergency Medicine;Equilibrium;experience;Feedback;Friends;functional decline;Goals;Health Personnel;Health Professional;Health Services;Health Services Research;Health system;Home;Hospitalization;Hospitals;human old age (65+);improved;improved outcome;insight;Instruction;International;Intervention;Interview;Investigator-Initiated Research;Learning;Measures;Mentors;Mentorship;Methods;military veteran;Modeling;Monitor;multidisciplinary;Nosocomial Infections;Outcome;patient population;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physicians;Pilot Projects;pilot test;Play;Population;Positioning Attribute;preference;Process;prototype;Provider;Qualitative Methods;Recording of previous events;Research;Research Design;Research Personnel;Research Priority;Research Project Grants;Risk;Role;Scientist;shared decision making;skill acquisition;skills;social;sociodemographics;surrogate decision making;Testing;Time;tool;Training;Uncertainty;usability;Variant;Veterans;Visit;Work

PROJECT_TITLE: A Shared Decision-Making Tool to Support Emergency Department Dispositions for Veterans with Dementia

STUDY_SECTION_NAME: Mentored Physician and Clinical Psychologist Scientist Award in Alzheimer’s Disease and Related Dementias [MRA1]