NIH_SPENDING_CATS: Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: PROJECT 1 NARRATIVE IDENTIFYING METABOLIC VULNERABILITIES REGULATED BY THE P53 FAMILY IN LUNG CANCER p53 is commonly mutated in human lung cancer, including lung adenocarcinoma, lung squamous cell carcinoma, and small cell lung cancer (SCLC), and is part of a family of genes, including p63 and p73, that interact extensively in human cancer. Project #1 will identify metabolic pathways utilizing novel mouse models of lung cancer with p53 gain of function and p63/p73 mutations found in human lung cancer, and cutting-edge metabolomics and genomics techniques to unveil novel therapeutic targets for lung tumors with p53 mutations or alterations in p63 and p73. Project #1 will also identify metabolic pathways regulated by p73, altered in 10% of human SCLC, a recalcitrant disease that lacks targeted therapies.

PI_NAMEs: FLORES, ELSA R (contact)

PROJECT_TERMS: anti-cancer research;Apoptosis;Binding;Biogenesis;cancer cell;cancer subtypes;cancer therapy;Cell Maintenance;ChIP-seq;Collaborations;Compensation;conditional knockout;Cysteine Metabolism Pathway;Data;Disease;Down-Regulation;efficacy evaluation;Family;Family member;Functional disorder;gain of function;Gene Expression Profile;Gene Family;Genomics;glucose metabolism;Glutathione Metabolism Pathway;Glycolysis;Goals;Homeostasis;Human;Immune;in vivo;interest;Knockout Mice;Knowledge;KRASG12D;Length;Lung Adenocarcinoma;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Methionine Metabolism Pathway;mouse model;Mus;mutant;Mutate;Mutation;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel;novel strategies;Oncogenic;Pathway interactions;Phenocopy;Phenotype;Pramlintide;pre-clinical;Pre-Clinical Model;programs;Protein Isoforms;Publishing;purine metabolism;pyrimidine metabolism;Role;skin organogenesis;small cell lung carcinoma;Squamous Cell Lung Carcinoma;stem cells;targeted treatment;Techniques;Testing;therapeutic target;Tissues;tool;TP53 gene;Transactivation;Transcriptional Regulation;tumor;Tumor Burden;tumor metabolism;Tumor Suppression;tumor-immune system interactions;Untranslated RNA;Work

PROJECT_TITLE: Project 1


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia;Pneumonia and Influenza

ORG_CITY: PROVIDENCE

ORG_COUNTRY: UNITED STATES

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_FIPS: US

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE According to the WHO seasonal influenza epidemics causes 3-5 million illnesses and about half a million deaths each year, and a major cause of morbidity and mortality from influenza infection is caused by secondary infection with bacterial pathogens. This project focuses on the role of an innate immune cell subset, the macrophage, and in particular cell death responses in the overall ability to clear complex respiratory infections with minimal morbidity and mortality. This will allow us to better understand a fundamental concept of complex respiratory infections.

PI_NAMEs: JAMIESON, AMANDA M (contact)

PROGRAM_OFFICER_NAME: ESPINOZA-PINTUCCI, MARISOL

PROJECT_TERMS: 5 year old;Alveolar Macrophages;antimicrobial;Apoptosis;Bacterial Infections;Bacterial Pneumonia;Biochemical;Biological Assay;CASP8 gene;Caspase;Categories;Cause of Death;Cell Death;Cell Death Induction;Cell Line;Cell Membrane Permeability;cell type;Cells;Cessation of life;Child;co-infection;Complex;Complication;Data;Disease;Equilibrium;Flow Cytometry;Foundations;Future;Genetic Models;global health;Hospitalization;Host resistance;Human;Imaging Techniques;Immune;Immune response;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Inflammasome;Influenza A virus;influenza epidemic;influenza infection;inhibitor;Lung;Lung infections;Macrophage;Membrane;Modeling;Morbidity - disease rate;mortality;mouse model;Mus;Mutation;Myeloid Cells;novel;pandemic virus;pathogen;pathogenic bacteria;Pathway interactions;Patients;Persons;pharmacologic;Play;Pneumonia;Population;Process;productivity loss;Research;Resistance;resistance mechanism;Respiratory Tract Infections;response;Role;seasonal influenza;secondary infection;Streptococcus pneumoniae;System;Testing;timeline;tissue-repair responses;transcriptomics;Viral;Virus Diseases

PROJECT_TITLE: Central role of Caspase-8 in control of host tolerance and resistance mechanisms in pulmonary macrophage populations during severe respiratory infections

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Brain Disorders;Clinical Research;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: Project Narrative There is a severe underrepresentation of African individuals in genetic studies of neurodevelopmental disorders (NDDs), including intellectual disability, autism spectrum disorders, and attention deficit disorder. We propose to address this inequity through the NeuroDev Kenya project, which aims to collect blood and clinical, medical and demographic data from 800 Kenyan children and adults with NDDs, as well as their parents, and age- and ancestry-matched unrelated controls. We will share all data (phenotypic and genetic) and materials (blood DNA) from the study, and integrate the project with extensive capacity building activities. NeuroDev will create a critical foundation for NDD genomics research in Africa.

PI_NAMEs: ABUBAKAR, AMINA ;NEWTON, CHARLES ;ROBINSON, ELISE B (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: 16p11.2;Address;Adult;Affect;Africa;African;African ancestry;Age;American;analysis pipeline;Area;Attention Deficit Disorder;autism spectrum disorder;Award;Behavioral;Bioethics;Blood;Cell Line;Child;Chronic;Clinical;Cognitive;cohort;Collection;Communities;Data;Data Analyses;Data Collection;Data Set;design;developmental disease;DNA;doctoral student;Enrollment;Environment;Epidemiology;Equity;Ethics;Etiology;exome sequencing;Fathers;Foundations;Funding;Genetic;genetic analysis;genetic disorder diagnosis;Genetic Research;genetic resource;Genetic study;Genetic Variation;genome sciences;genomic data;Genomics;Genotype;Grant;Guidelines;Health;Heterogeneity;Individual;Inequity;Infant Mortality;Institution;Intellectual functioning disability;International;Kenya;Link;Measures;Medical;Medical Genetics;Medical Research;medical schools;Mothers;Neurodevelopmental Disorder;neuropsychiatric disorder;non-verbal;Output;Parents;Participant;Phenotype;phenotypic data;Pilot Projects;Prevalence;programs;Protocols documentation;Public Health Schools;rare genetic disorder;recruit;Research;Research Institute;Research Personnel;Resources;Risk;Rural;Site;social;South Africa;Structure;Testing;tool;Training;United States National Institutes of Health;Work

PROJECT_TITLE: NeuroDev Kenya: characterizing the epidemiology and etiology of developmental disorders on the Kenyan Coast


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

ORG_CITY: TAMPA

ORG_NAME: H. LEE MOFFITT CANCER CTR & RES INST

ORG_STATE: FL

PHR: PROJECT 2 NARRATIVE INVESTIGATING CYSTEINE ESSENTIALITY IN LUNG CANCER Cysteine plays a crucial role in cellular survival and proliferation by generating multiple functional biomolecules, but the factors influencing the cellular response to cysteine starvation are incompletely understood. We have found that lung cancer cells are dependent on exogenous cystine due to a lack of transsulfuration capacity, but exhibit a heterogeneous response to cystine limitation. This work will evaluate the influence of metabolic circuits, cellular genotype, and microenvironmental factors on cellular responses to cystine limitation.

PI_NAMEs: DENICOLA, GINA MARIE (contact)

PROJECT_TERMS: Alveolar;cancer cell;Cancer cell line;Catalysis;Cell Culture Techniques;Cell Death;Cell Proliferation;Cell Survival;Cells;Cessation of life;Compensation;Consumption;Culture Media;Cyst;Cystathionine;Cysteine;Cysteine Metabolism Pathway;Cystine;Cytoprotection;Dependence;deprivation;Diet;Dipeptides;Energy Transfer;Environment;Enzyme Induction;Enzymes;Epithelial Cells;Exhibits;extracellular;Genotype;Glutamates;Glutathione;Glycine;Goals;Immune;Impairment;in vivo;interstitial;KRASG12D;Liquid substance;LoxP-flanked allele;Lung;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Mediating;Metabolic;Metabolism;metabolome;Mus;neoplastic cell;Non-Small-Cell Lung Carcinoma;Oxidation-Reduction;Play;Population;Primary carcinoma of the liver cells;Proliferating;Proteins;Resistance;resistance mechanism;response;Role;Serine;Serum;Source;Starvation;Sulfur;Testing;Therapeutic Intervention;therapeutic target;Tissues;transcription factor;Treatment Efficacy;tumor;tumor microenvironment;uptake;Work

PROJECT_TITLE: Project 2


ADMINISTERING_IC: AG

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Brain Disorders;Dementia;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: SAN FRANCISCO

ORG_NAME: J. DAVID GLADSTONE INSTITUTES

ORG_STATE: CA

PHR: PROJECT NARRATIVE Progress in Alzheimer’s disease (AD) research will benefit from new tools for detecting behavioral changes that occur in early disease stages, when therapies are likely to be most effective at halting or reversing disease progression. We propose to develop a new AI-based method for detecting subtle behavioral changes in late- onset AD mouse models that lack clear behavioral impairments when tested with traditional behavioral approaches. The proposed research will contribute a new urgently-needed tool for understanding and measuring behavioral changes in AD and will increase the usefulness of mouse models of late-onset AD for the development of new therapies aimed at improving behavioral and cognitive health in AD patients.

PI_NAMEs: MILLER, STEPHANIE REGINA (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TERMS: 3-Dimensional;Acute;AD transgenic mice;Address;Affect;Age Months;Aging;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease patient;Alzheimer's disease therapeutic;Amyloid;Amyloid Beta A4 Precursor Protein;Amyloid beta-Protein;Antibodies;apolipoprotein E-4;artificial intelligence method;Award;Behavior;Behavior assessment;behavior measurement;behavior test;Behavioral;Behavioral Assay;behavioral impairment;behavioral phenotyping;Behavioral Research;Biological Markers;Biotechnology;Body part;Brain Pathology;Clinical;Cognitive;cohort;Collection;Complex;Computer Vision Systems;Consumption;Custom;Data;data mining;data visualization;Defect;Dementia;detection method;detection platform;Development;Diagnosis;Disease;Disease Progression;Early Diagnosis;experience;Exploratory Behavior;familial Alzheimer disease;Female;Genes;Goals;Grooming;Health;Height;Histology;Human;Image;Impaired cognition;improved;innovation;Investigational Therapies;Knock-in;Knock-in Mouse;Laboratories;Late Onset Alzheimer Disease;Machine Learning;machine learning method;machine learning pipeline;male;Methodology;mild cognitive impairment;Modeling;Monitor;Monoclonal Antibodies;morris water maze;Motion;mouse model;Movement;Mus;neural network;Neurodegenerative Disorders;Neurosciences;next generation;novel;novel therapeutics;overexpression;Pathogenesis;Pharmaceutical Preparations;pharmacologic;Phenotype;Physiological;pre-clinical;Pre-Clinical Model;pre-clinical research;Prognostic Factor;Publishing;rapid testing;repository;Reproducibility;Research;research study;sex;Side;Speed;stem;Symptoms;Testing;Therapeutic;therapeutic development;Therapeutic Research;therapy development;Time;tool;Training;Transgenic Mice;Transgenic Organisms;translational barrier;Translational Research;translational study;Universities;Validation

PROJECT_TITLE: Machine Learning Approaches for Behavioral Phenotyping of Humanized Knock-in Models of Alzheimer's Disease


NIH_SPENDING_CATS: Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Orphan Drug;Rare Diseases

PHR: PROJECT 3 NARRATIVE ROLES AND MECHANISMS OF ACTION OF METABOLIC VULNERABILITIES OF SCLC To identify new therapeutic targets for small cell lung cancer (SCLC), a recalcitrant disease that lacks targeted therapies, we performed state-of-the-art mass spectrometry-based screens for SCLC-specific changes in the ATP binding proteome, expressed proteome, and the metabolome. We identified metabolic hubs that are selectively up-regulated in both treatment naïve and chemoresistant SCLC and showed that combined pharmacological inhibition or genetic loss of MCT lactate transporters and the PFKFB3 glycolytic enzyme provokes SCLC metabolic collapse, growth arrest and cell death. Using new and established mouse models of SCLC, patient-derived SCLC tumors and circulating tumor cells from SCLC patients, Project #3 will assess the roles of MCT transporters and PFKFB3 in controlling the metabolism, development and maintenance of SCLC, will test if co-targeting MCT and PFKFB3 delays or eliminates emergence of resistant disease, alone or when combined with standard-of-care chemotherapy, and will identify additional metabolic vulnerabilities of SCLC.

PI_NAMEs: CLEVELAND, JOHN L. (contact)

PROJECT_TERMS: Alanine;Amino Acids;Binding;Biological Assay;Cancer cell line;cancer genomics;Cancer Model;Cancer Patient;cancer therapy;Carbon;Cell Death;Cell Survival;checkpoint therapy;Chemoresistance;chemotherapy;Cholesterol;Cisplatin;Classification;Clinic;Clinical;Collaborations;Combined Modality Therapy;CRISPR screen;Cysteine;data integration;Data Set;Development;Disease;Disease Resistance;Drug Screening;druggable target;effective therapy;efficacy study;embryonic stem cell;enzyme activity;Enzymes;Epidermal Growth Factor Receptor;Etoposide;experimental study;Fatty Acids;Genetic;genetic approach;Genetic Engineering;Genetic study;Genetically Engineered Mouse;genomic profiling;Glucose;Glutamates;Glutamine;Glycolysis;Growth;Hexoses;Human;Immunologic Surveillance;Immunosuppression;Impairment;in vivo;inhibitor;inorganic phosphate;Knock-out;Lactate Transporter;Lead;lipid metabolism;lipidomics;loss of function mutation;Maintenance;Malignant neoplasm of lung;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic;Metabolism;metabolome;metabolomics;mouse model;Mus;mutant;Neoplasm Circulating Cells;neoplastic cell;new therapeutic target;Non-Small-Cell Lung Carcinoma;novel therapeutics;Oleates;Oncogenic;overexpression;Oxidative Phosphorylation;patient derived xenograft model;Patients;pharmacologic;Phosphotransferases;prevent;Primary Neoplasm;Proteome;Proteomics;Proto-Oncogene Proteins c-myc;purine metabolism;relapse patients;Resistance;response;Retinoblastoma Protein;retinoblastoma tumor suppressor;Role;safety study;safety testing;small cell lung carcinoma;standard of care;Structure of parenchyma of lung;Survival Rate;synergism;targeted treatment;Testing;Therapeutic;TP53 gene;transcription factor;transcriptome sequencing;treatment strategy;tumor;tumor metabolism;Tumor Tissue;tumor xenograft;Tumor-infiltrating immune cells;Up-Regulation;validation studies;Xenobiotics;Xenograft procedure

PROJECT_TITLE: Project 3


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Lewy Body Dementia;Neurodegenerative;Neurosciences;Palliative Care;Prevention

ORG_CITY: CHICAGO

ORG_DEPT: NEUROSURGERY

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

ORG_STATE: IL

PHR: PROJECT NARRATIVE Lewy Body Dementia (LBD) is the second most common form of dementia and has unique symptoms that lead to more frequent hospital visits, shorter survival, and increased strain on family caregivers, yet no LBD-specific caregiver interventions exist. This study will determine whether a practical, LBD-specific educational intervention delivered by trained and experienced LBD caregiver peer mentors can (1) improve the wellbeing of current LBD caregivers and their care recipients, and (2) provide a successful framework for harnessing the knowledge of expert caregivers to support future caregivers in LBD and other dementias.

PI_NAMEs: FLEISHER, JORI ERIN (contact)

PROGRAM_OFFICER_NAME: RIDDLE, MELISSA

PROJECT_TERMS: Accident and Emergency department;Acute;Address;Adoption;Affect;Alzheimer's Disease;Attention;attentional control;Attitude;Behavioral Model;care recipients;caregiver education;caregiver interventions;Caregiver research;caregiver strain;Caregivers;Characteristics;Cognitive;community engaged approach;Data;Dehydration;Dementia;dementia care;Dementia caregivers;design;Disease;Education;Educational Curriculum;Educational Intervention;Educational Materials;Electronic Mail;Emergency department visit;Ensure;experience;falls;Family Caregiver;family support;Focus Groups;Foundations;Funding;Future;Goals;Health;health care service utilization;Hospitalization;Hospitals;implementation fidelity;improved;Infection;Institutionalization;Institutionalized Persons;Intervention;intervention effect;Intervention Studies;Interview;Knowledge;Lewy Body Dementia;Link;Lived experience;Maintenance;Malignant Neoplasms;Mediator;Mental Health;Mentors;Methods;Modeling;Morbidity - disease rate;mortality;Motor;motor symptom;Neurobehavioral Manifestations;neuropsychiatric symptom;neuropsychiatry;novel;Outcome;Parkinson Disease;Patient-Focused Outcomes;Patients;peer coaching;peer support;Personal Satisfaction;Persons;physical conditioning;Pilot Projects;Positioning Attribute;Predictive Factor;programs;psychosocial;Quality of life;Randomized;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;Reporting;Resources;Risk;Sample Size;satisfaction;skills;Social support;Structure;success;Symptoms;Testing;theories;Time;Training;treatment arm;treatment as usual;United States National Institutes of Health;Visit;week trial;Work

PROJECT_TITLE: PERSEVERE in Lewy Body Dementia: A Randomized, Controlled Trial of Peer Mentor Support and Caregiver Education

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Networking and Information Technology R&D (NITRD);Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: FALL RIVER

ORG_NAME: EMITECH, INC.

PHR: Project Narrative The goal of this Phase II proposal is to develop a commercially viable wearable device as a forearm bracelet, for rapid, on-site testing for opioids and other narcotics with wireless alerts. We demonstrated the feasibility of this approach in Phase I. The Phase II effort will focus on further development and optimization to provide ultra-high sensitivity (ng/mL detection range), enhanced drug specificity, long-term durability, low power consumption, and cost-effective production. Upon completion of Phase II, 20 devices will have been produced and will be ready for commercialization.

PI_NAMEs: LEVITSKY, IGOR A (contact)

PROGRAM_OFFICER_NAME: SABIRZHANOV, BORIS YEVGENYEVICH

PROJECT_TERMS: Address;Antibodies;Area;Biological Markers;Biosensor;Bluetooth;Cellular Phone;Chlorine;commercialization;commercialization readiness;Computers;conditioning;cost;cost effective;cross reactivity;Data;Detection;detection limit;Development;Devices;disease diagnostic;Drug Monitoring;Electrodes;Electrolytes;fabrication;Family member;Fentanyl;Forearm;Funding;Glucose;Goals;Health;Heroin;Human;human subject;Illicit Drugs;Immobilization;Individual;innovation;Intake;Legal patent;Maintenance;Manuals;Marketing;Methods;microchip;Monitor;Morphine;Nanoporous;Narcotics;non-opioid analgesic;novel strategies;Opioid;opioid epidemic;opioid use disorder;Patients;Pharmaceutical Preparations;Phase;Porosity;power consumption;Preparation;printed circuit board;Printing;Production;prototype;Provider;Public Health;Publications;Published Comment;Readiness;Safety;Sales;sensor;Sensory;sensory integration;Signal Transduction;Silicon;Site;Small Business Innovation Research Grant;Sodium;Source;Specificity;Surface;Technology;Testing;United States;wearable device;wearable sensor technology;wireless;wireless communication

PROJECT_TITLE: Wearable sensor for opioids detection based on electrochemical sensor arrayintegrated with Bluetooth device


NIH_SPENDING_CATS: Cancer;Immunotherapy;Lung;Lung Cancer

PHR: PROJECT 4 NARRATIVE: METABOLIC AND FUNCTIONAL REPROGRAMMING OF  IMMUNOSUPPRESSIVE MYELOPOIESIS IN LUNG TUMORS This application will identify an elusive metabolic mechanism centrally governing the function and expansion of myeloid-derived suppressor cells (MDSC) in lung tumors, which could significantly increase the efficacy of promising approaches for cancer immunotherapy. Specifically, information gathered from this effort is expected to: 1) provide insights into the metabolic signals underlying the tolerogenic polarization of MDSC in lung tumors; 2) set the foundation for the development of novel strategies to functionally reprogram myelopoiesis in cancer; and 3) enhance the effectiveness of major anti-cancer treatments including radio, chemo, and immunotherapy by transforming “cold” tumors into “hot” malignancies highly infiltrated by reactive T cells and reprogrammed immunogenic myeloid cells that sustain significant anti-tumor activities.

PI_NAMEs: RODRIGUEZ, PAULO CESAR (contact)

PROJECT_TERMS: Ablation;Agonist;anti-cancer treatment;Antioxidants;Beds;Binding;Biology;Bone Marrow;cancer immunotherapy;Cancer Patient;carcinogenesis;CD8-Positive T-Lymphocytes;Cell Count;Cell Physiology;Cells;Cellular Stress;checkpoint therapy;Clinical;Cystine;Data;Detection;Development;DNA;effective therapy;Effectiveness;Endoplasmic Reticulum;endoplasmic reticulum stress;Event;experience;Extravasation;Foundations;Goals;Homeostasis;Immune;Immunity;Immunocompetent;immunogenic;Immunotherapy;Impairment;In Situ;in vivo;Infiltration;information gathering;inhibitor;insight;Interferon Type I;Interferons;Link;lung cancer cell;Lung Neoplasms;Malignant neoplasm of lung;Malignant Neoplasms;Mediating;Mediator;Metabolic;Metabolism;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Monitor;Mus;Myeloid Cells;Myeloid-derived suppressor cells;Myelopoiesis;Nature;novel strategies;novel therapeutic intervention;Pathway interactions;Patients;Phosphotransferases;predicting response;Process;Production;programs;Proteins;Radio;Reaction;Reactive Oxygen Species;Reporting;response;Role;Seminal;Signal Transduction;Stimulator of Interferon Genes;Stress;success;synergism;T cell response;T-Lymphocyte;Testing;Therapeutic;TP53 gene;tumor;Tumor Immunity;tumor microenvironment;Tumor-infiltrating immune cells

PROJECT_TITLE: Project 4


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Brain Disorders;Cocaine;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Mental Health;Neurosciences;Stimulant Use and Misuse;Substance Misuse

ORG_CITY: NASHVILLE

ORG_DEPT: DENTISTRY

ORG_NAME: MEHARRY MEDICAL COLLEGE

ORG_STATE: TN

PHR: PROJECT NARRATIVE Antiretroviral therapy (ART) is the only treatment option for the ~38 million people living with HIV. However, life- long adherence to ART is associated with neurological and neuropsychiatric side effects. Notably, the comorbid condition of cocaine use exacerbates these deficits. This proposal will assess the combined effects of HIV-1 integrase inhibitor-based antiretroviral therapy and chronic cocaine use on neuronal dysfunction and neuropsychiatric circuit reorganization.

PI_NAMEs: DASH, CHANDRAVANU  (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Adherence;Adverse effects;Affect;Anti-Retroviral Agents;antiretroviral therapy;Biochemical;Biochemistry;Biology;Brain;Calcium;Calcium Channel;Calcium Signaling;Chromosomes;Chronic;Clinical;Clinical Research;Cocaine;cocaine exposure;cocaine use;Cocaine use disorder;Communication;comorbidity;Data;Disease;Drug abuse;Drug usage;Effectiveness;Electrophysiology (science);Equilibrium;excitatory neuron;excitotoxicity;extracellular;Functional disorder;Genetic;Genetic study;Glutamate Receptor;glutamatergic signaling;Glutamates;Goals;HIV;HIV Infections;HIV-1;HIV-1 integrase;HIV/AIDS;improved;in vivo;Individual;Induced Neurons;Infection;inhibitor;Integrase;Integrase Inhibitors;Knowledge;Length;Measures;Mediating;Metabolic;Molecular;Molecular Target;Mus;N-Methylaspartate;Neurites;Neurocognitive Deficit;Neurologic;Neurologic Deficit;neuronal circuitry;Neuronal Dysfunction;Neurons;Neuropathogenesis;neuropsychiatric disorder;neuropsychiatry;Neurosciences;neurotransmission;novel strategies;Nucleus Accumbens;Pathway interactions;Persons;pharmacologic;Pharmacology Study;Play;postsynaptic;Qualifying;Regimen;Reporting;Research;response;reward circuitry;Role;Severities;side effect;Signal Pathway;Signal Transduction;Synapses;synaptic function;Testing;Therapeutic;Viral Load result;Virus;voltage

PROJECT_TITLE: Role of GRIN2 in ART and SUD associated neurological deficits.


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse;Underage Drinking

ORG_CITY: BROOKLYN

ORG_NAME: SUNY DOWNSTATE MEDICAL CENTER

ORG_STATE: NY

PHR: Project Narrative  Childhood trauma exposure, particularly in the form of interpersonal violence, increases risk for alcohol use disorder (AUD), posttraumatic stress disorder (PTSD) and their co-occurrence, perhaps through complex interactions of molecular genetic risk, and trauma-related disturbances in neural development; however, knowledge is limited in this area due to limitations of prior research, including lack of longitudinal data in multiple domains and reliance on outdated genetic designs. Using cutting-edge statistical genetics techniques and results from existing “big data” genome wide association studies, aggregate genetic risk scores indexing risk unique and common to these disorders will be integrated into sophisticated longitudinal analyses of adolescent and young adult neural connectivity and risk for adult AUD and PTSD. Results from this study will shed light on these important public health conditions and will yield important implications for prevention and intervention efforts.

PI_NAMEs: AMSTADTER, ANANDA B;MEYERS, JACQUELYN LEIGH (contact)

PROGRAM_OFFICER_NAME: GITIK, MIRI

PROJECT_TERMS: Adolescence;Adolescent and Young Adult;Adult;Adult Children;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol risk;alcohol use disorder;Area;Behavior;Big Data;Binding;Brain;Brain-Derived Neurotrophic Factor;Candidate Disease Gene;Cannabis;Childhood;Clinical;comorbidity;Complex;Consumption;Data;Data Set;design;Development;Disease;Distal;drinking;Electroencephalography;Environmental Risk Factor;Equation;Etiology;Exhibits;Exposure to;Family;Family history of;Feeling suicidal;Female;Frequencies;Genes;Genetic;Genetic Predisposition to Disease;Genetic Risk;Genetic Techniques;genetics of alcoholism;genome wide association study;genome-wide;Genomics;Growth;Heritability;Hippocampus;indexing;Intercept;Interpersonal Violence;Intervention;Interview;Investigation;Knowledge;late life;life span;Literature;longitudinal analysis;Longitudinal Studies;Measurement;Measures;Mental Depression;Methodology;Methods;Modeling;Molecular;neural;Neurobiology;Neurocognitive;Neurocognitive Deficit;neurodevelopment;Nicotine;novel;Outcome;Participant;Pathway interactions;pediatric trauma;Phenotype;physical conditioning;polygenic risk score;Post-Traumatic Stress Disorders;Prevention;Prognosis;Prospective Studies;Psychopathology;Public Health;Research;Retrospective Studies;Risk;Risk Factors;risk sharing;Sampling;Scoring Method;Severities;sex;Sex Differences;sexual trauma;Statistical Methods;statistics;Structure;substance use;Symptoms;trait;Trauma;trauma exposure;Variant;Woman;Work;young adult;young adult alcohol use

PROJECT_TITLE: Genetic relationships between PTSD and Alcohol Use Disorder: Integrating GWAS and Deeply Phenotyped Longitudinal data.

STUDY_SECTION: BGES

STUDY_SECTION_NAME: Behavioral Genetics and Epidemiology Study Section[BGES]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Wnt5a-Ror signaling is one of the key cell-cell communication systems that controls embryonic tissue morphogenesis, and its dysregulation causes birth defects and cancer metastasis. We propose a multidisciplinary research program aimed to elucidate how the originating cells release Wnt5a signals, how the responding cells perceive and process these signals. Knowing the mechanisms underlying Wnt5a-Ror signaling will help us better understand the pathogenesis of the associated human diseases, thus facilitating the therapeutic development for cancers driven by aberrant Wnt5a-Ror signaling.

PI_NAMEs: HUANG, PENGXIANG  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Adult;ascorbate;beta catenin;Binding;Biochemistry;Biological Assay;Carrier Proteins;Cell Communication;Cell fusion;Cell membrane;Cells;Cellular biology;Chemicals;Clinical;Complex;Congenital Abnormality;Cryoelectron Microscopy;Cysteine-Rich Domain;Cytoplasm;Cytoplasmic Tail;Development;Dimerization;Disease;Drosophila genus;Dsh protein;Dwarfism;embryo tissue;Endoplasmic Reticulum;Event;Exhibits;experimental study;extracellular;Extracellular Domain;Face;Family;G-Protein-Coupled Receptors;Genitalia;Homodimerization;Human;human disease;improved;In Vitro;Inflammatory;Interdisciplinary Study;Label;Ligand Binding;Ligands;Limb structure;Lipids;Malignant Neoplasms;Methodology;Modeling;Modification;Molecular Conformation;Morphogenesis;Mutation;Neoplasm Metastasis;Nonesterified Fatty Acids;novel;palmitoleic acid;Pathogenesis;Pathogenicity;Pathologic;Pathway interactions;Peroxidases;Phosphorylation;Physiological;Play;Process;programs;Property;Proteins;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;reconstitution;recruit;Recycling;Resolution;Robinow syndrome;Role;ROR1 gene;Serine;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Structure;System;Testing;Therapeutic;therapeutic development;Time;transcription factor;Transmembrane Domain;WNT5A protein;Work

PROJECT_TITLE: Mechanisms of mammalian Wnt5a-Ror signaling

STUDY_SECTION: CSRS

STUDY_SECTION_NAME: Cellular Signaling and Regulatory Systems Study Section[CSRS]


PHR: CORE 1 PROJECT NARRATIVE  ADMINISTRATIVE CORE The Administrative Core serves as the central node for all Projects and Cores of the Program Project Grant (PPG) with the overarching goal of providing resources and facilitating interactions between the laboratories involved. The Administrative Core has 3 goals: 1.) to provide administrative services including organization of meetings and annual retreats, 2.) to ensure robust integration of project and core activities with the highest level of scientific rigor and reproducibility of data, and 3.) to support internal and external resource and data sharing. These goals will be accomplished through the efforts of the leadership of the Core Leaders and two PhD level support staff, the Program Management Director and the Administrative Director.

PROJECT_TERMS: Achievement;Administrator;animal imaging;Area;Biological;Budgets;Cancer Center;cancer subtypes;Collaborations;Communication;Communities;comparative;Conceptions;Data;Data Analyses;data repository;Data Science;Data Science Core;data sharing;data submission;Databases;Development;Disease;Doctor of Philosophy;Ensure;experience;experimental analysis;Experimental Designs;experimental study;Fostering;Goals;Institution;Institutional Policy;Laboratories;Leadership;Malignant neoplasm of lung;Malignant Neoplasms;meetings;member;Metabolic;Metabolism;Methods;Modeling;Molecular;mouse model;National Cancer Institute;operation;Phenotype;Postdoctoral Fellow;Preparation;Procedures;Program Research Project Grants;programs;Progress Reports;public database;Publications;quality assurance;Records;Regulation;Reproducibility;Resource Sharing;Resources;Role;Sampling;Scientist;Services;success;synergism;timeline;Training;tumor metabolism;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Rare Diseases

ORG_CITY: NEW YORK

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Narrative Reliable evaluation of lymph nodes (LNs) is essential for proper disease management. However, current non- invasive methods cannot reliably distinguish metastatic LNs from non-metastatic LNs. The proposed study will develop low-cost, in-vivo, ultrasonic instrumentation for more-reliable metastasis detection and hence for improved staging and treatment of disease.

PI_NAMEs: MAMOU, JONATHAN  (contact)

PROGRAM_OFFICER_NAME: WU, YICONG

PROJECT_TERMS: Acoustics;Address;Affect;Algorithms;Anxiety;Area;artificial neural network;attenuation;Benign;Biopsy;Classification;Clinical;Collaborations;cost;Cytology;Data;data acquisition;Detection;Discriminant Analysis;Disease;Disease Management;Disseminated Malignant Neoplasm;electric impedance;Evaluation;Excision;Fine needle aspiration biopsy;Foundations;Image;improved;in vivo;in vivo evaluation;instrument;instrumentation;laptop;Lead;Light Microscope;lymph node biopsy;Lymph Node Tissue;lymph nodes;Lymphoma;Magnetic Resonance;Medical;Medicine;Metastatic Neoplasm to Lymph Nodes;Methods;Micrometastasis;Microscopic;Modeling;Neoplasm Metastasis;New York;Nonmetastatic;Operating Rooms;Operative Surgical Procedures;Outcome;Pathologist;patient population;Patient Recruitments;Patients;Performance;personalized care;Procedures;Process;Property;Prostate;quantitative ultrasound;Research;Research Personnel;Research Project Grants;Risk;ROC Curve;side effect;Signal Transduction;Slice;Slide;Specimen;Staging;standard of care;statistics;support vector machine;Surgical Pathology;synergism;System;Testing;Thyroid Gland;Time;time use;Tissues;tool;treatment planning;Ultrasonics;ultrasound;Universities;Validation;virtual

PROJECT_TITLE: In vivo Evaluation of Lymph Nodes Using Quantitative Ultrasound

STUDY_SECTION: ITD

STUDY_SECTION_NAME: Imaging Technology Development Study Section[ITD]


NIH_SPENDING_CATS: Behavioral and Social Science;Breastfeeding, Lactation and Breast Milk;Infectious Diseases;Microbiome;Neurosciences;Nutrition;Obesity;Pediatric;Prevention;Women's Health Research

ORG_DEPT: NEUROSCIENCES

PHR: Prepregnancy obesity predisposes affected offspring to adverse long-term health outcomes, including cognitive dysfunction; yet, the underlying pathophysiology remains unclear. Our interdisciplinary study in a mouse model for diet-induced obesity will test the two-part hypothesis that (1) Western diet-induced dysbiosis of the maternal gut microbiome is causally related to offspring neurocognitive dysfunction and (2) antenatal targeting of the maternal gut microbiome can improve offspring brain development and cognitive outcomes. Successful completion of the aims will reveal the impact of Western diet consumption on the structure and function of the maternal gut microbiome and microbially-derived metabolome during pregnancy, elucidate the molecular and neurophysiological mechanisms by which opportunistic pathogenic bacteria increased by Western diet consumption impair host cognitive function, and identify targeted modulation of the maternal gut microbiome as an innovative approach to improving cognitive health outcomes in children affected by maternal prepregnancy diet-induced obesity.

PI_NAMEs: BUFFINGTON, SHELLY A (contact)

PROGRAM_OFFICER_NAME: RUSSO, DENISE

PROJECT_TERMS: Address;Adverse effects;Affect;Amino Acids;Amygdaloid structure;Animal Model;antenatal;antenatal care;Antibiotics;Attenuated;Bacteroides;Behavior;Behavioral;Biological Assay;Brain;Branched-Chain Amino Acids;burden of chronic illness;Catabolism;Cephalosporins;Child;Chronic Disease;Cognition Disorders;Cognitive;Cognitive deficits;cognitive function;Combined Modality Therapy;Consensus;Consumption;Data;Development;Diet;diet-induced obesity;disadvantaged women;disorder risk;dysbiosis;early life exposure;Electrophysiology (science);Environment;epidemiology study;Exhibits;Exposure to;Fatty acid glycerol esters;FDA approved;fecal transplantation;fetal;Functional disorder;Genetic;Germ-Free;Growth;gut dysbiosis;gut microbiome;gut microbiota;Health;high body mass index;Hippocampus;Homeostasis;Human;Human Milk;ileum;Impaired cognition;Impairment;improved;in utero;Infant;innovation;Interdisciplinary Study;Intervention;Lactation;Light;maternal obesity;Measures;Memory;metabolome;metabolomics;Metagenomics;Metformin;microbial;microbial community;microbiota;Molecular;Mothers;mouse model;multiple omics;Mus;Mutation;nervous system development;Neurocognitive;neurophysiology;Neurosciences;non-genetic;novel therapeutics;Obesity;offspring;opportunistic pathogen;Outcome;pathogen;pathogenic bacteria;Pathologic;Pathway interactions;Penicillins;permissiveness;personalized approach;pharmacologic;Pharmacologic Substance;Phenotype;postnatal;Postpartum Period;pre-clinical;Pregnancy;prenatal;prepregnancy;prepregnancy obesity;Prevalence;prevent;Preventive treatment;probiotic therapy;Probiotics;Protein Biosynthesis;Publishing;Serum;social health determinants;Socioeconomic Status;soluble fiber;Structure;Synaptic plasticity;Testing;transmission process;Transplant Recipients;Up-Regulation;Weight Gain;western diet;Whole-Genome Shotgun Sequencing;Woman;Work

PROJECT_TITLE: Targeting opportunistic pathogens to improve maternal obesity-associated health outcomes in offspring

STUDY_SECTION: NMHD

STUDY_SECTION_NAME: Nutrition and Metabolism in Health and Disease Study Section[NMHD]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Genetics;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Stem Cell Research;Stem Cell Research - Embryonic - Non-Human

PHR: CORE 2 PROJECT NARRATIVE PRECLINICAL MODELS AND PATHOLOGY CORE The Preclinical Models and Pathology Core (Core #2) is a central component of the Program in Lung Cancer Metabolism. Core #2 will provide three extraordinary services and expertise that are not provided as Cancer Center standard shared resources: 1) generation of speedy mouse models with alterations in metabolic genes, 2) digital pathology driven by artificial intelligence to rapidly and quantitatively assess the cancer outcome in these mouse models, and 3) integrated research-focused pathology services and resources to validate the conclusions from mouse models using well-annotated human specimens and organoid models.

PI_NAMEs: CRESS, WILLIAM DOUGLAS (contact)

PROJECT_TERMS: Acceleration;Adenocarcinoma;Adenocarcinoma Cell;algorithm development;Alleles;Animal Experiments;animal tissue;Animals;Antibodies;Artificial Intelligence;Biological Markers;blastocyst;Brassicaceae;Breeding;Cancer Center;cancer imaging;Cancer Model;Cells;Chimera organism;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collaborations;Complex;Consultations;Core Facility;Critical Pathways;Data;data dictionary;Data Set;deep learning;Derivation procedure;Development;Diagnosis;Diagnostic;digital;digital pathology;DNA cassette;embryo cryopreservation;embryonic stem cell;Environment;Enzymes;Evaluation;Experimental Designs;Fertilization in Vitro;fluorescence imaging;Gene Expression;Gene Targeting;Generations;Genes;Genetically Engineered Mouse;Genotype;high resolution imaging;histological specimens;Histology;Histopathology;homologous recombination;Human;human tissue;Image;Image Analysis;immune cell infiltrate;Immunofluorescence Immunologic;Immunohistochemistry;in vivo;Individual;inducible gene expression;Injections;innovation;interest;Investigation;Knowledge;Libraries;Lung;Lung Neoplasms;lung tumorigenesis;machine learning algorithm;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Measurement;Metabolic;method development;Microscopic;model development;Modeling;Molecular;mouse model;Mus;novel;Organoids;Outcome;Pathologic;Pathologist;Pathology;Patients;pre-clinical;Pre-Clinical Model;predictive modeling;Process;Production;programs;quantitative imaging;repository;Research;Research Personnel;Resolution;Resource Sharing;Resources;service learning;Services;Slide;small cell lung carcinoma;Specimen;Speed;sperm cryopreservation;Squamous cell carcinoma;Structure;success;Tissue Microarray;tissue resource;Training;Transgenic Organisms;tumor;Tumor Burden;tumor growth;tumor metabolism;Validation;Writing;zygote

PROJECT_TITLE: Pre-Clinical Core


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: CAMBRIDGE

ORG_NAME: HARVARD UNIVERSITY

PHR: PROJECT NARRATIVE We propose to develop a high-pressure freezing instrument with the buffer exchange capability (HPF-X) for time- resolved cryo-vitrification of cells and tissues with a goal to study ligand-induced biological processes at high spatiotemporal resolution. Biomedical applications of this technique include nanoscale imaging of rapid protein- protein interactions (e.g., receptor-effector coupling), post-translational modifications (e.g., phosphorylation), and protein-membrane dynamics (e.g., exo- and endocytosis). Our custom-built high-pressure freezer with the buffer exchange capability will allow full control, versatility, and potential for adoption and modification by other researchers based on their project needs, which cannot be achieved with off-the-shelf HPF instruments.

PI_NAMEs: PRIGOZHIN, MAXIM  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adoption;Antibodies;Atmospheric Pressure;bioimaging;Biological;Biological Process;biological research;Buffers;Cell Physiology;Cells;chemical fixation;Coupling;Cryo-electron tomography;Cryoelectron Microscopy;cryogenics;Custom;cytokine;Data;design;Development;Devices;Diamond;Disease;Electron Microscopy;Endocrinology;Endocytosis;Ethane;Event;fluorescence imaging;Freezing;Future;Goals;Health;high resolution imaging;Hormones;Ice;Image;Imaging ligands;imaging modality;Imaging Techniques;Immunology;improved;innovation;instrument;Ions;Label;Lifting;Ligands;Liquid substance;live cell imaging;Maps;Membrane;Membrane Proteins;meter;method development;Methods;Microfluidics;Microscopy;Modification;Molecular;Motion;nanobodies;nanoscale;Neurosciences;Optics;Organism;Outcome;Peptides;Performance;Pharmaceutical Preparations;pharmacologic;Pharmacology;Phosphorylation;Post-Translational Protein Processing;preservation;pressure;Process;protein protein interaction;Proteins;prototype;Qualifying;receptor;Relaxation;Research Personnel;Resolution;response;Sample Size;Sampling;Series;small molecule;spatiotemporal;Specific qualifier value;Stimulus;superresolution microscopy;System;Techniques;Technology;temporal measurement;Thermal Conductivity;Thick;Time;Tissue Sample;Tissues;tool;ultra high resolution;Validation;virology;Virus;Visualization;Wait Time;Work

PROJECT_TITLE: HPF-X: High-pressure freezing with buffer exchange

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


PHR: CORE 3 PROJECT NARRATIVE  METABOLISM CORE The Metabolism Core (Core #3) provides services to support the projects and is a central and key component of this program project grant (PPG). The goal of Core #3 is to provide experience and expertise to support experimental design, sample preparation, data acquisition, quality control, collaboration with Core #4 for analysis, and assistance with biological interpretation of results to support the research proposed by the PPG project investigators. The faculty and staff involved in Core #3 apply complementary metabolomics and proteomics approaches to address complex hypotheses in preclinical models (e.g. cell lines, xenografts, and genetically engineered mouse models) as well as human tumors and actively collaborate to maximize the availability and utility of the results.

PI_NAMEs: KOOMEN, JOHN M (contact)

PROJECT_TERMS: activity-based protein profiling;Address;Archives;assay development;Biological;Biological Assay;Cancer Biology;Cancer Center;Cancer Patient;Cell Communication;Cell Line;Collaborations;Complex;Computer software;Conceptions;Core Grant;Cysteine Metabolism Pathway;Data;data acquisition;Data Analyses;data integration;data repository;Data Science;Data Science Core;Data Scientist;Data Set;Dedications;design;Development;Enzyme Inhibition;Enzymes;Equipment;experience;Experimental Designs;experimental study;Faculty;Family member;Gas Chromatography;Genetically Engineered Mouse;Genomics;Glycolysis;Goals;Grant;Guidelines;Human;Immune system;improved outcome;Individual;interest;Intervention;Knowledge;lipid metabolism;liquid chromatography mass spectrometry;Location;Lung Neoplasms;Malignant neoplasm of lung;Maps;Mass Chromatography;Mass Fragmentography;Mass Spectrum Analysis;member;Metabolic;Metabolic Pathway;Metabolism;metabolomics;method development;Methods;Molecular;molecular scale;Monitor;multiple datasets;Myeloid-derived suppressor cells;novel;Pathology;Pathway interactions;Phenotype;Play;Post Translational Modification Analysis;potential biomarker;Pramlintide;Pre-Clinical Model;Preparation;preservation;Program Research Project Grants;Protein Analysis;Proteins;Proteomics;public repository;Publications;Publishing;quality assurance;Quality Control;Research;Research Personnel;Research Support;response;Role;sample collection;Sampling;Services;small cell lung carcinoma;Stable Isotope Labeling;success;Sulfhydryl Compounds;synergism;Techniques;Testing;tool;TP53 gene;tumor;Tumor Biology;Tumor Escape;tumor immunology;tumor metabolism;Tumor-infiltrating immune cells;Work;Xenograft procedure

PROJECT_TITLE: Metabolomics Core


ORG_CITY: SAINT LOUIS

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: NARRATIVE The proper assembly of membrane proteins as folded subunits or macromolecular complexes, is of critical importance to cellular physiology, yet we do not have a fundamental understanding of the physical reasons why membrane proteins assemble in the hydrophobic environment of the membrane. In this project, we are studying the equilibrium dimerization reaction of the CLC-ec1 Cl-/H+ antiporter as a model system to dissect the thermodynamic driving forces underlying membrane protein association in lipid bilayers. The results from this study will identify the molecular mechanisms for how protein sequence, lipid composition and general anesthetics modulate stability, and thereby lay down a physical foundation for the development of new strategies aimed at correcting stability defects in membrane protein folding diseases.

PI_NAMEs: ROBERTSON, JANICE L (contact)

PROGRAM_OFFICER_NAME: TAYLOR, VERONICA

PROJECT_TERMS: alpha helix;Amino Acid Sequence;antiporter;Binding;Biological Models;Cell membrane;Cell Physiology;Cells;CLC Gene;Computer Models;computer studies;Computing Methodologies;Defect;Development;dimer;Dimerization;Dissociation;driving force;enthalpy;Entropy;Environment;Equilibrium;Exhibits;experimental study;Fatty Acids;Fluorescence;Fluorobenzenes;Foundations;Free Energy;General anesthetic drugs;Grain;Hydrophobicity;interfacial;Kinetics;Laboratories;Link;Lipid Bilayers;Lipids;Macromolecular Complexes;Measurement;Measures;Membrane;membrane assembly;Membrane Proteins;Methods;Microscopy;Modeling;Molecular;molecular dynamics;molecular modeling;Mutation;novel;Nutrient;pharmacologic;Phase;physical model;Physiological;Physiology;Property;protein folding;protein structure;Protein-Folding Disease;Proteins;Reaction;Regulation;Research Design;Role;Route;Sampling;self assembly;single molecule;Solvents;Specificity;Sterols;Structure;Temperature;Theoretical model;theories;Thermodynamics;Time;Tryptophan;wasting

PROJECT_TITLE: Driving forces of membrane protein assembly in membranes


ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: Chicago

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

PHR: Project Narrative Multi-Tagger is an automated tool for assigning publication types and study designs to biomedical articles, preprints and manuscripts. We propose to develop Multi-Tagger 2.0, to handle a wider variety of study designs, articles, users and use cases, and to ensure that the data are disseminated in a form that is appropriate to each different type of user. These studies will indirectly impact on human health by greatly enhancing retrieval of relevant articles by a wide range of biomedical end-users, including groups studying the effectiveness of medical interventions, those studying preclinical animal models of human disease, and pharmaceutical companies developing new drug treatments.

PI_NAMEs: SMALHEISER, NEIL R (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Animal Model;Automated Indexing;Bibliographic Databases;Data;Databases;effectiveness study;Explosion;Guidelines;Health;Human;human disease;human model;improved;indexing;Infrastructure;Intervention;Journals;Literature;machine learning method;machine learning model;Manuals;Manuscripts;Medical;Methods;Modeling;neural;novel therapeutics;Performance;Pharmacologic Substance;preclinical study;Printing;prototype;Publications;Publishing;PubMed;Research Design;Research Personnel;Retrieval;Students;systematic review;Text;tool;United States National Library of Medicine;vector

PROJECT_TITLE: Automated Indexing for Publication Types and Study Designs


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Data Science;Genetics;Human Genome;Lung;Lung Cancer;Networking and Information Technology R&D (NITRD)

PHR: CORE 4 PROJECT NARRATIVE  DATA SCIENCE CORE The Data Science Core (Core #4) is an integral part of the research mission of this P01 to identify metabolic vulnerabilities in lung cancer. The goal of the Core #4 is to provide comprehensive, multidisciplinary expertise to support the data science needs of program investigators, with a focus on reproducible research. The Core #4 consists of faculty and staff with a diverse skill set and expertise in providing data science support in the areas of biostatistics, statistical genomics, bioinformatics, and informatics.

PI_NAMEs: STEWART, PAUL ALLEN (contact)

PROJECT_TERMS: Area;Bioinformatics;bioinformatics tool;Biometry;Cancer Patient;ChIP-seq;Computer software;Data;Data Analyses;data exchange;data integration;data quality;data repository;Data Science;Data Science Core;data sharing;data visualization;Databases;design;Development;digital;Ensure;experience;Experimental Designs;experimental study;Faculty;FAIR principles;Genomics;Goals;Guidelines;high dimensionality;Immunotherapy;improved;In Vitro;in vitro Model;in vivo Model;Informatics;innovation;Knowledge Discovery;Lead;Location;Lung;Malignant neoplasm of lung;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;member;Metabolic;Metabolism;metabolomics;Metadata;method development;Methods;Mission;Molecular;Molecular Analysis;multidisciplinary;novel therapeutic intervention;Outcome;Pathologic;Pathology;Pre-Clinical Model;Preparation;Procedures;Program Research Project Grants;programs;Proteomics;Quality Control;Randomized;Reporting;Reproducibility;Research;research and development;Research Personnel;Research Project Grants;Research Support;response;Sampling;Services;skills;Specimen;Statistical Data Interpretation;synergism;Therapeutic;therapeutic target;tool;transcriptome sequencing;transcriptomics;translational research program;Translations;virtual;Visualization;Visualization software;Work

PROJECT_TITLE: Data Science Core


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: Project Narrative Understanding the process of photoreceptor development is crucial for revealing molecular mechanisms that cause inherited photoreceptor dystrophies as well as for proposing therapeutic approaches that aim to restore visual function via the regeneration of lost photoreceptors. While significant progress has been made in understanding the signaling cascades that regulate photoreceptor development, the role of epigenetic mechanisms in this process has been explored to a lesser degree. The objective of our study is to explore the role of the DNA demethylation pathway in photoreceptor normal and pathological development.

PI_NAMEs: IVANOV, DMITRY V (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: Ablation;Animal Model;Applications Grants;Binding;Biochemical;Blindness;Cell Differentiation process;Cessation of life;Code;Complex;Cone;Data;demethylation;Development;Dioxygenases;Disease;DNA;DNA Binding Domain;DNA Methylation;Enzymes;Epigenetic Process;Experimental Designs;Eye Development;Family;fetal;Gene Activation;Gene Expression;Gene Silencing;Genes;Genetic;genome-wide;Genomic DNA;Genomic Segment;Human;Hypermethylation;Inherited;inhibitor;Laboratories;Lead;Methylation;Modeling;Molecular;Mus;Mutation;Natural regeneration;neurogenesis;Pathogenesis;Pathologic;Pathology;Pathway interactions;Phenotype;Photoreceptors;postnatal;prevent;Process;progenitor;promoter;Promoter Regions;Protein Family;Protein translocation;Publishing;Retina;Retinal Cone;Retinal Degeneration;retinal progenitor cell;retinal rods;Retinitis Pigmentosa;Rod;Role;Signal Transduction;Specific qualifier value;stem cell differentiation;Study Section;Testing;Therapeutic;transcription factor;USH2A gene;Vertebrate Photoreceptors;Vision;Zebrafish

PROJECT_TITLE: The role of the TET-dependent DNA demethylation pathway in photoreceptor development and pathology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-F(02)M]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Herpesviruses are important human pathogens that can have devastating effects in neonates and immunocompromised individuals, yet there is no cure for any herpesvirus and treatment options are lacking. Here, I dissect the mechanism of an essential feature of the herpesviral lifecycle - viral genome packaging - by exploring the role of a unique accessory factor required for packaging and by developing an assay to monitor packaging in vitro. Detailed mechanistic insight is essential to understand the mechanism of current antiherpesviral drugs and to facilitate the identification of new targets for antivirals.

PI_NAMEs: DIDYCHUK, ALLISON LOUISE (contact)

PROGRAM_OFFICER_NAME: PARK, EUN-CHUNG

PROJECT_TERMS: Address;Adopted;Africa South of the Sahara;Anti-viral Agents;Area;Award;Bacteriophages;Behavior;Biochemical;Biochemistry;Biological Assay;Biology;biophysical properties;Biophysics;Cancer Etiology;Capsid;Charge;Complex;Congenital Abnormality;Coupled;Development;Disease;Dissection;DNA Viruses;drug discovery;Drug Targeting;Evolution;FDA approved;Foundations;Genome;Goals;Herpes encephalitis;Herpes Labialis;Herpesviridae;High Prevalence;high reward;high risk;HIV;Homologous Gene;Human;Human Herpesvirus 8;human pathogen;Immunocompromised Host;In Vitro;in vivo;Individual;Infection;inhibitor;insight;interest;Investments;Kaposi Sarcoma;Label;Life;Life Cycle Stages;Malignant Neoplasms;Mass Spectrum Analysis;Methodology;Methods;Microscopy;Molecular;Molecular Motors;Molecular Virology;Monitor;Motor;Mutagenesis;mutation screening;neonate;new therapeutic target;novel;Nucleic Acid Binding;Oncogenic;pathogen;Pharmaceutical Preparations;Positioning Attribute;Process;programs;Proteins;Proteomics;reconstitution;Regulation;Research Personnel;resistance mutation;Resources;Role;scaffold;structural biology;Structure;success;System;Tail;Techniques;terminase;Testing;Time;Viral;Viral Genome;Viral Packaging;Viral Proteins;virology;Virus;Virus Replication;Vision;Work

PROJECT_TITLE: Dissecting the mechanism of herpesvirus genome packaging


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Immunotherapy;Pancreatic Cancer;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: PROJECT NARRATIVE Senescence of cancer cells is a common outcome of antitumoral therapies which can affect the functionality of T cells; still, it is unclear how senescence influences T cell function. In this project, I aim at dissecting how triggering of senescence in cancer cells promotes an antitumoral, T cell-mediated, immune response. The results of these studies will inform on how to potentiate conventional cancer therapies by favoring tumor immunosurveillance.

PI_NAMEs: MEZZADRA, RICCARDO  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Advisory Committees;Affect;anti-cancer;anti-tumor immune response;Antitumor Response;Area;Behavior;Bystander Effect;Cancer Biology;cancer cell;cancer genetics;Cancer Model;cancer therapy;career development;Cell Aging;Cell Communication;Cell Cycle Arrest;cell mediated immune response;Cell Physiology;Cells;Cellular biology;checkpoint inhibition;collaborative environment;CSF3 gene;cytokine;Data;design;Development Plans;Engineering;Environment;Exclusion;experimental study;Faculty;Flow Cytometry;Genetic;Genetic Induction;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Immune;immune checkpoint blockade;Immune response;Immunity;Immunocompetent;Immunologic Surveillance;Immunology;Immunosuppression;Immunotherapy;in vivo;insight;Institution;interest;irradiation;Laboratories;Lead;liver cancer model;Macrophage Colony-Stimulating Factor;Malignant neoplasm of gastrointestinal tract;Mediating;Mediator;Memorial Sloan-Kettering Cancer Center;Mentors;Microscopy;Modeling;mouse model;Mus;Myeloid-derived suppressor cells;neoantigens;neoplastic cell;novel;novel therapeutics;Outcome;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma model;pharmacologic;Positioning Attribute;programs;RAS inhibition;rational design;recruit;Research;research and development;Research Personnel;Resources;Role;Scientist;senescence;senescence associated secretory phenotype;senescent cell;Series;Signal Transduction;skills;Stimulus;Stress;support network;synergism;System;T cell infiltration;T cell response;T-Lymphocyte;Testing;tool;Training;Treatment Efficacy;tumor;tumor microenvironment;tumor progression;Tumor Suppression;Tumor Suppressor Proteins;Tumor-infiltrating immune cells;Vocational Guidance

PROJECT_TITLE: Investigating the interplay between senescence and T cell immunity

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Neurosciences;Pain Research

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Development and function of the nervous system requires the establishment of exquisitely selective cellular interactions between neurons and supporting cells. The axonal endings of pain-sensing sensory neurons are wrapped by specific types of skin cells into structures called ensheathment channels, which are conserved from worms to mammals and thus likely play critical roles in the development and function of pain sensors. To better understand how epidermal ensheathment contributes to establishing and maintaining functional pain-sensing neurons, this proposal uses zebrafish larvae as an accessible model for studying how axons and skin cells recognize each other, how skin cells wrap around axons, and how ensheathment contributes to sensory function.

PI_NAMEs: SAGASTI, ALVARO  (contact)

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Adherens Junction;Adult;Affect;Animals;Axon;Basal Cell;Behavioral Assay;Caenorhabditis elegans;Cell membrane;Cell Physiology;cell type;Cells;Chemicals;Cholesterol;Complement;CRISPR screen;CRISPR/Cas technology;Dendrites;Desmosomes;Development;Disease;Drosophila genus;Epidermis;epidermis cell;Epithelial Cells;Epithelium;Event;experimental study;F-Actin;Fishes;fly;Functional disorder;Grant;Human;Image;Individual;innovation;Integral Membrane Protein;keratinocyte;knock-down;Larva;Lipids;Mammals;Mechanics;Mediating;Membrane;Methods;Microscopy;Modeling;Molecular;Morphogenesis;Mutagenesis;Neck;Nervous System Physiology;neural circuit;Neurites;Neuroglia;neuron development;Neurons;Neurophysiology - biologic function;Nociception;Nociceptors;optogenetics;Pain;pain sensation;Periderm;Peripheral;plakoglobin;Play;Process;Proliferating;Property;protein distribution;Proteins;receptor;recruit;repaired;Reporter;response;Role;Schwann Cells;seal;sensor;Sensory;Signal Transduction;Site;Skin;somatosensory;Stimulus;Structure;Study models;Subcellular structure;superresolution imaging;Supporting Cell;System;temporal measurement;Testing;tool;Touch sensation;transcriptome;Transgenic Organisms;Vertebrates;virtual;Work;Zebrafish

PROJECT_TITLE: Morphogenesis and function of somatosensory axon ensheathment by epidermal cells


ADMINISTERING_IC: MH

ED_INST_TYPE: GRADUATE SCHOOLS

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Mental Health;Neurosciences;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: PSYCHOLOGY

ORG_NAME: COLUMBIA UNIV NEW YORK MORNINGSIDE

PHR: Project Narrative Resilience, defined as successful development and coping despite exposure to adversity, is primarily studied in high-income countries (HICs), which is problematic, as most children grow up in low- and middle-income countries (LMICs) where they are at the greatest risk for profound adversity exposures. The proposed research addresses this critical knowledge gap regarding pathways towards resilience by combining sophisticated data analytic techniques applied to longitudinal multimodal brain imaging, high-dimensional behavioral assessments, and comprehensive defining of environmental exposures (both adverse and protective) from a well-established and deeply-characterized birth cohort of adolescence with significant adversity exposure living in Cape Town, South Africa. Here, we examine neuro-environmental pathways supporting adolescents’ emotion regulation behaviors with the goal of improving precision and inclusivity in recognizing and characterizing resilience to socio-economic, structural, health, and interpersonal adversities.

PI_NAMEs: SEEDAT, SORAYA ;TOMLINSON, MARK ;TOTTENHAM, NIM  (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: 13 year old;Accounting;Address;Adolescence;Adolescent;Age;Algorithms;Amygdaloid structure;analytical method;Behavior;Behavior assessment;Behavioral;Birth;Brain;Brain imaging;Child;Childhood;Chronic;clinically significant;cohort;Communities;computerized;coping;Country;Data;Data Analytics;Data Collection;Development;early adolescence;early life adversity;emotion dysregulation;emotion regulation;Emotions;Enrollment;Environment;Environmental Exposure;Event;evidence base;experience;Exposure to;Factor Analysis;Family;Goals;Grant;Health;high dimensionality;high risk;Human;improved;Income;Individual Differences;Inequity;Knowledge;Life;Link;Longitudinal Studies;low and middle-income countries;machine learning method;Magnetic Resonance Imaging;Measures;Mediator;Mental disorders;Mental Health;Modeling;morphometry;multimodality;neural correlate;neurobehavioral;Neurobiology;neuroimaging;Outcome;Parents;Participant;Pathway interactions;Patient Self-Report;Pattern;Phenotype;Play;Population;Poverty;Predictive Factor;Pregnancy;Pregnancy Trimesters;prenatal;prenatal exposure;Process;promote resilience;prospective;protective factors;Puberty;random forest;Recovery;Reporting;Research;resilience;resilience factor;retention rate;Risk;Risk Factors;risk mitigation;Role;Sampling;Schools;Second Pregnancy Trimester;sex;Shapes;showing emotion;Social Environment;Socialization;socioeconomics;Source;South Africa;South African;Techniques;Testing;Time;Violence;Work;Youth

PROJECT_TITLE: Resilient Emotion Regulation Development in a South African Birth Cohort

STUDY_SECTION: CPDD

STUDY_SECTION_NAME: Child Psychopathology and Developmental Disabilities Study Section[CPDD]


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Dietary Supplements;Drug Abuse (NIDA only);Neurosciences;Nutrition;Substance Misuse

ORG_CITY: LA JOLLA

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE This project proposal seeks to understand the heterogeneity of the blood-brain barrier (BBB) and how it might differentially control the microenvironment of functionally distinct brain regions. The results of this work will address fundamental questions about BBB differences in transport, metabolism, and signaling according to function, thus yielding critical knowledge about BBB dysfunction associated with neuropsychiatric diseases and aging. In addition, by specifically investigating the BBB role at the nucleus accumbens shell, we aim to study molecular mechanisms of addiction in hopes to uncover therapeutic targets for treatment or prevention.

PI_NAMEs: GARCIA-PAK, IRIS HALEAKALA (contact)

PROJECT_TERMS: Acute;addiction;Address;Adult;Affect;Aging;All-Trans-Retinol;Alzheimer's Disease;Area;Basal Ganglia;Behavior;Biological;Blood - brain barrier anatomy;Blood brain barrier dysfunction;Blood Vessels;Brain;brain endothelial cell;Brain region;Cell Differentiation process;Cell Survival;cell type;Central Nervous System;Cerebellum;Cochlear nucleus;conditional knockout;Corpus striatum structure;Development;Developmental Process;Diet;dietary;Disease;Dopamine;Dopamine D2 Receptor;Dopamine Receptor;Drug Addiction;Endothelial Cells;Endothelium;Environment;Equilibrium;Exhibits;extracellular;Gene Expression;Gene Expression Profile;Genes;Goals;Health system;Heterogeneity;Hippocampus;Homeostasis;Hypothalamic structure;Immune system;Individual;interest;Knock-out;Knockout Mice;Knowledge;learned behavior;Learning;Membrane;Metabolism;Molecular;Mus;Nervous System Disorder;Nervous System Physiology;neural;neural circuit;Neurons;neuropsychiatric disorder;Nucleus Accumbens;Organ;Pathway interactions;Peripheral;Predisposition;Prevalence;Prevention;Property;Psychological reinforcement;Public Health;receptor;Retinoids;Rewards;Role;RXR;Self Administration;Sensory;Severities;Signal Transduction;single-cell RNA sequencing;Source;Specific qualifier value;Specificity;Spinal Cord;Stimulus;Tamoxifen;Testing;Thalamic structure;therapeutic target;Time;Tissue-Specific Gene Expression;Tissues;Toxin;Traumatic Brain Injury;Tretinoin;Variant;Ventral Striatum;Vitamin A;Work

PROJECT_TITLE: What is the role of blood-brain-barrier regional specificity in the nucleus accumbens?


NIH_SPENDING_CATS: Eczema / Atopic Dermatitis;Neurosciences

ORG_DEPT: DERMATOLOGY

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: NARRATIVE: Chronic itch is a significant clinical problem, affecting nearly 10 to 20% of the general population and negatively impacts the quality of life and productivity of those affected. No universally effective treatments are available for chronic itch due to a lack of understanding of the mechanisms underlying the production and regulation of chronic itch. The current proposal aims to identify the cells and molecules involved in regulating the itch sensation in the skin in the hopes of finding novel drug targets for treating chronic itch.

PI_NAMEs: HU, HONGZHEN  (contact)

PROJECT_TERMS: Ablation;Acute;Affect;Afferent Neurons;Allergic;Allergic Contact Dermatitis;Animal Model;Applications Grants;Atopic Dermatitis;Automobile Driving;Binding;C Fiber;Cells;Chemicals;Chronic;chronic itch;Clinical;Code;conditional knockout;Conscious;Cutaneous;cytokine;Data;Development;Dryness;effective therapy;Esthesia;Experimental Models;Fiber;G-Protein-Coupled Receptors;General Population;Generations;Genetic;genetic approach;Goals;Human;in vivo;Ion Channel;Knock-out;Lead;Light;mast cell;mechanical force;Mechanical Stimulation;mechanical stimulus;Mechanics;Mechanoreceptors;Mediating;Mediation;Mediator;Membrane;Merkel Cells;Modality;Modeling;Molecular;mouse model;Mus;Neurons;new therapeutic target;novel therapeutic intervention;novel therapeutics;optogenetics;Pathogenesis;Patients;Pattern;Piezo 2 ion channel;Pilot Projects;Play;Population;Process;Production;Productivity;Pruritus;Quality of life;Regulation;Role;Self-Injurious Behavior;Sensory;Signal Transduction;Skin;skin disorder;skin irritant;somatosensory;Spinal Cord;Testing;tissue injury;Topical application;TRP channel;TRPV1 gene

PROJECT_TITLE: Deciphering the Piezo2-Merkel cell signaling mechanisms in itch

STUDY_SECTION: SPS

STUDY_SECTION_NAME: Somatosensory and Pain Systems Study Section[SPS]


NIH_SPENDING_CATS: Aging;Clinical Research;Dissemination and Implementation Research;Emergency Care;Health Services;Infectious Diseases;Lung;Patient Safety;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: Columbus

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Pneumonia is diagnosed in over half a million U.S. ED visits by older adults each year and has high mortality. Currently, emergency physicians lack the tools to reliably diagnose pneumonia and deliver life-saving care to the correct patients. This proposal seeks to improve diagnostic accuracy thereby improving patient care and outcomes by: investigating novel serum tests; deriving and piloting a new diagnostic pathway; and applying group concept mapping to prepare for successful validation and implementation.

PI_NAMEs: BUCK, KATHERINE HUNOLD (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Accident and Emergency department;accurate diagnosis;Address;Adoption;Adult;Adverse effects;adverse outcome;alpha-Defensins;anti-microbial peptide;Antibiotics;Bacteria;Bacterial Infections;Bacterial Pneumonia;Biological Markers;Caring;Cessation of life;Clinical;clinical care;clinical diagnostics;clinical predictors;co-infection;Communities;comorbidity;concept mapping;COVID-19 impact;Defensins;Development;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic criteria;diagnostic strategy;Diagnostic tests;Disabling;Early Diagnosis;Emergency Department patient;Emergency Department Physician;Emergency department visit;Emergency Medicine;Ensure;Event;experience;Face;Female;Future;future implementation;Genes;Geriatrics;Goals;Guidelines;Health;Human;human old age (65+);Image;implementation barriers;implementation science;implementation study;implementation trial;improved;Infection;Innate Immune System;Investigation;Length of Stay;Leukocytes;Life;lung failure;male;Maps;Measures;Methodology;Methods;Mission;Modeling;monocyte;Morbidity - disease rate;mortality;Natural Immunity;novel;novel diagnostics;novel marker;older adult;Outcome;Participant;pathogen;pathogenic bacteria;pathogenic virus;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Physicians;Pneumonia;predictive modeling;prevent;prospective;Proteins;Qualifying;Recommendation;Recording of previous events;Research Priority;Rural;Sepsis;Serum;Source;Subgroup;Symptoms;Testing;Theoretical Domains framework;Thinking;Thoracic Radiography;Time;tool;United States;usability;Validation;validation studies;Viral;Viral Pneumonia;Virus;Virus Diseases;Width;Work;young adult

PROJECT_TITLE: Establishing and Implementing Pneumonia Diagnosis in ED Older Adults: A Mixed Methods Approach


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Human Genome;Kidney Disease;Orphan Drug;Patient Safety;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: DAVIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: UNIVERSITY OF CALIFORNIA AT DAVIS

PHR: PROJECT NARRATIVE Although significant progress has been made in developing new drugs in kidney cancer, there are no biomarkers to guide treatment decisions post-operatively in patients with localized kidney cancer. Majority patients, particularly those with high-risk features in their tumors relapse after surgery; therefore, making it necessary to develop a biomarker to help identify these patients as well as to guide treatment in the adjuvant setting. In this proposal, I will investigate strategies to identify novel transcriptomic and metallomic biomarkers of poor-risk kidney cancer, to determine if we can identify patients most likely to benefit from adjuvant therapies, minimize exposure of toxic drugs to those at low risk of recurrence and overall improve the outcomes of patients with kidney cancer.

PI_NAMEs: GULATI, SHUCHI  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adjuvant;Adjuvant Therapy;Adoption;Binding;Bioinformatics;Biological Markers;biomarker development;biomarker identification;biomarker validation;Biopsy;California;Cancer Biology;cancer recurrence;career;career development;Categories;Cessation of life;Characteristics;Clear Cell;Clear cell renal cell carcinoma;Clinical;Clinical Trials;clinically relevant;cohort;Collaborations;Complex;Copper;Coupled;cytochrome c oxidase;Data;Development;Discipline;Disease;Disease-Free Survival;early experience;Educational workshop;Electron Transport;Environment;Excision;experience;experimental study;functional genomics;Future;Gene Expression;Gene Proteins;Genes;genetic signature;Goals;high risk;Histologic;Immunohistochemistry;immunological status;Immunotherapy;improved;improved outcome;Individual;Inductively Coupled Plasma Mass Spectrometry;inhibitor;K-Series Research Career Programs;Kidney Neoplasms;Knowledge;Laboratories;Laboratory Scientists;Los Angeles;Major Histocompatibility Complex;Malignant Neoplasms;Measurement;Measures;Mentors;Mentorship;Metabolic;Metabolic Pathway;metabolomics;Metformin;Methods;Mitochondria;Molecular;molecular marker;Molecular Sieve Chromatography;Necrosis;Neoplasm Metastasis;novel;novel therapeutic intervention;novel therapeutics;Operative Surgical Procedures;patient stratification;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phenotype;Population;Postoperative Period;precision medicine;predictive modeling;Primary Neoplasm;Prognosis;prognostic;Prognostic Marker;prognostic signature;prognostic significance;prognostic value;prospective;Publishing;Quantitative Reverse Transcriptase PCR;Recurrence;Relapse;relapse risk;Renal Carcinoma;Renal Cell Carcinoma;Research;Research Personnel;Respiration;Ribosomal Proteins;Risk;Risk Assessment;Risk Reduction;Sampling;Serum;side effect;skills;Specific qualifier value;Staging System;Stratification;The Cancer Genome Atlas;Therapeutic Clinical Trial;Tissues;Tobacco smoking behavior;Toxicant exposure;Training;Transcript;transcriptome sequencing;transcriptomics;translational approach;translational cancer research;Translational Research;tumor;Tyrosine Kinase Inhibitor;United States Food and Drug Administration;Universities;Validation;Vascular Endothelial Growth Factors

PROJECT_TITLE: Combination of Transcriptomic and Metallomic Biomarkers for Risk Assessment in Locoregional Clear Cell Renal Cell Carcinoma

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Cancer;Genetics;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: This project will be a substantial contribution to public health by systematicallydeep annotating thefunction of new genes (NGs) in cancer and neurodegenerative diseases such as Alzheimer's disease. These systematic annotation results will be performed through ChimerAnno (a tool for functional annotation of human chimeric genes), FGviewer (a tool for visualizing multi-tiered functional features of fusion genes), NGeffector with DeepChIP (a tool for predicting NG downstream effectors with enhanced transcription factor binding site prediction with deep learning), DeepCLIP (a tool for providing evidence of origin of NGs for trans-splicing mechanism) and hBPAI (a tool for feature extraction of human new genes' breakpoint (BP)). The application of these approaches on all kinds of human BPs of new genes will be integrated into NewGeneDB, New Gene annotation Database. This study will advance our knowledge in NG regulatory mechanisms in diseases and open up the possibility of novel treatments of cancer tools and platforms for analyzing NGs. and other diseases in the future by providing powerful

PI_NAMEs: KIM, PORA  (contact)

PROGRAM_OFFICER_NAME: WANG, PEGGY

PROJECT_TERMS: ABL1 gene;Achievement;Alzheimer's Disease;Antineoplastic Agents;Binding;Binding Sites;bioinformatics tool;Biological Markers;cancer therapy;CCND2 gene;Cell Death;chimeric gene;Chimeric Proteins;Complex;cost;Databases;deep learning;Development;Disease;Disease Progression;DNA Binding Domain;Drug Targeting;EWSR1 gene;feature extraction;fusion gene;Future;gene function;Gene Structure;Genes;Human;Human Genome;In Vitro;in vivo;Individual;insight;Knowledge;leukemia;Leukemic Cell;Malignant Neoplasms;Methods;Neurodegenerative Disorders;novel;NUP214 gene;Phosphotransferases;precision medicine;predictive tools;Procedures;Public Health;Recruitment Activity;Research;Role;RUNX1 gene;Source;Stat5 protein;therapeutic target;Tissues;tool;Trans-Splicing;Transcript;transcription factor;Visualization software

PROJECT_TITLE: Functional annotation of new genes aided by deep learning

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-K(55)R]


ORG_DEPT: BIOLOGY

PHR: NARRATIVE Understanding how long-lived protective immunity mediated by CD8 T cells is established and sustained in tissues is of significant importance to human health. Establishing residence in tissues requires adaptation of CD8 T cells to diverse and dynamic metabolic environments encountered in distinct organs. Defining the metabolic adaptations of CD8 T cells in specific tissue environments informs our understanding of how these cells protect against pathogens and tumors and maintain function at tissue barrier sites and informs the strategic design of therapeutic and protective vaccines to protect from infection and malignancies.

PI_NAMEs: GOLDRATH, ANANDA W (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Bacterial Infections;cancer cell;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Maintenance;Cell Survival;Cells;Cellular biology;Cellular Metabolic Process;Cholesterol;cholesterol biosynthesis;Cholesterol Homeostasis;Circulation;cofactor;Coupled;CRISPR/Cas technology;Cues;Cytoprotection;Data;Dependence;design;Development;Down-Regulation;driving force;effector T cell;Environment;Epigenetic Process;Exposure to;extracellular;Gene Expression Profiling;Generations;Genetic Transcription;Health;Homeostasis;Human;Immune;Immune response;Immune signaling;Immunity;Impairment;improved;in vivo;Infection;Intestines;Maintenance;Malignant Neoplasms;Mediating;Mediator;Memory;Metabolic;Metabolic Pathway;Metabolism;metabolomics;microbiome;MicroRNAs;Modeling;Molecular;neoplastic cell;Nutrient;opportunistic pathogen;Organ;Organism;pathogen;Pathway interactions;Phase;Play;Population;prevent;programs;Regulation;residence;Residencies;Resolution;response;Role;screening;Site;Small Intestines;T cell differentiation;T memory cell;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;tissue resident memory T cell;Tissues;transcription factor;transcription regulatory network;tumor;tumor growth;tumorigenesis;Up-Regulation;Vaccines;Variant;Virus Diseases

PROJECT_TITLE: T cell maintenance: molecular mediators of T cell differentiation and survival


NIH_SPENDING_CATS: Adolescent Sexual Activity;Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Childhood Injury;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Social Determinants of Health;Substance Misuse;Violence Against Women;Violence Research;Women's Health Research;Youth Violence;Youth Violence Prevention

ORG_CITY: Alameda

ORG_NAME: SCIENTIFIC ANALYSIS CORPORATION

PHR: 8. Project Narrative Alcohol researchers have long sought to disentangle the precise relationship between intoxication and sexual encounters. Examining the relationships between intoxication and sexual health have been important for public health researchers in developing effective prevention and intervention programs to counter a number of serious alcohol-related problems. In order to assist the development of more effective intervention programs, but also importantly further our understanding of the relational processes that are involved within these intoxicated sexual encounters, the aim of this qualitative research proposal is to identify and analyze the key elements operating by conducting in- depth qualitative interviews with 200 young adults (18-25).

PI_NAMEs: HUNT, GEOFFREY P (contact)

PROGRAM_OFFICER_NAME: FREEMAN, ROBERT

PROJECT_TERMS: Address;Adopted;age group;Aggressive behavior;Alcohol consumption;alcohol effect;alcohol expectancy;alcohol related problem;Alcoholic Intoxication;Alcohols;Attention;Behavior;Belief;cisgender;college;Consent;Data;Development;Dimensions;Disinhibition;drinking;Education;effective intervention;Elements;Emotional;Enrollment;Epidemiology;Ethnography;Evidence based practice;Expectancy;expectation;experience;Feedback;Formulation;Freedom;Gender;gender difference;Guidelines;harassment;Heterosexuals;Incidence;Inequity;Informed Consent;innovation;insight;intervention program;Interview;Intoxication;Left;men;Movement;operation;Outcome;Participant;Pattern;Persons;Play;Policies;Prevention;Prevention program;Process;psychologic;public drinking;Public Health;Qualitative Research;Reaction;recruit;Research;Research Personnel;Research Project Grants;Research Proposals;Role;Schedule;Series;Sex Behavior;sexual assault;sexual encounter;Sexual Harassment;Sexual Health;sexual victimization;sexual violence;Sexuality;Shapes;social;Social Interaction;social media;social science research;social structure;Sociology;Specificity;structural determinants;Surveys;Techniques;theories;Victimization;Violence;web site;Woman;Workplace;young adult;young woman

PROJECT_TITLE: INTOXICATED SEXUAL ENCOUNTERS: ALCOHOL, SEXUAL SCRIPTS AND CONSENT AMONG YOUNG ADULTS

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: NARRATIVE Alzheimer’s disease and related disorders (AD/ADRD) are the most common neurodegenerative disease of aging, affecting millions of Americans and increasing in prevalence each year. Here, via this R35 Leadership Award, the PI, Dr. Stuart Lipton, who is the developer of several of the current FDA-approved drugs for AD, will mentor junior faculty and trainees in drug development, and pursue new pathways toward novel drug development for AD/ADRD using the very considerable Drug Discovery Facilities and Chemistry Department of Scripps Research in La Jolla, California.

PI_NAMEs: LIPTON, STUART A (contact)

PROGRAM_OFFICER_NAME: RUNKO, ALEXANDER PETER

PROJECT_TERMS: Address;Affect;aging related disease;Alzheimer's Disease;Alzheimer's disease related dementia;American;Amyloid beta-Protein;assay development;Award;Biochemistry;Bioinformatics;Biology;California;Chemicals;Chemistry;clinical candidate;Clinical Trials;Computational Biology;Development;Disease;drug action;Drug Design;drug development;drug discovery;Drug Industry;Faculty;FDA approved;Goals;graduate school;high throughput screening;Human;improved;Infrastructure;Institution;Investigation;Investigational Drugs;Knowledge;Laboratories;Leadership;Medical;Medicine;Mentors;Modeling;Neurodegenerative Disorders;Neurosciences;news;novel;novel therapeutics;Pathway interactions;Pharmaceutical Chemistry;Pharmaceutical Preparations;Pharmacology;Prevalence;Process;programs;Research;Research Personnel;Resources;Scientist;structural biology;symposium;Therapeutic;Therapeutic Agents;therapeutic target;Training;United States National Institutes of Health;virtual

PROJECT_TITLE: Leadership in AD/ADRD Drug Discovery


ORG_NAME: UNIVERSITY OF CHICAGO

PHR: PROJECT NARRATIVE The human gut microbiome plays an important role in human health, yet the molecular mechanisms by which microbes interact at the cellular and ecosystem scale are largely unknown. This research program will develop a new framework to elucidate the genetic determinants that govern the behaviour of microbial communities across scales. Through genetic engineering of gut bacteria, we will investigate the collective ecological and metabolic phenomenon that emerge from the interactions of individual microbial traits.

PI_NAMEs: MIMEE, MARK  (contact)

PROGRAM_OFFICER_NAME: KEANE-MYERS, ANDREA

PROJECT_TITLE: Microbial Engineering to Control the Structure and Function of the Gut Microbiome.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-GGG-X(55)R]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Clinical Research;Emerging Infectious Diseases;Genetics;Human Genome;Infectious Diseases;Prevention;Rare Diseases;Tuberculosis

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

PHR: Project Narrative This project will characterize genetic variants that alter immune function and thereby decrease the risk that a tuberculosis-infected patient will progress to active symptoms, which can inform the development of therapeutic and vaccine strategies that augment resilience against progression. Elucidating how immune phenotypes are altered by genetic background will also refine our understanding of basic immune physiology and shed greater functional light on the genetic component of risk for other infectious and inflammatory illnesses. Finally, this work will produce a powerful novel method for association testing in single-cell datasets—Covarying Neighborhood Analysis—that represents a marked advancement in our ability to characterize disease states, therapeutic mechanisms, and basic physiology by defining with unprecedented flexibility and granularity the cell populations whose abundance is altered by any phenotype of interest.

PI_NAMEs: RUMKER, LAURIE ANN (contact)

PROGRAM_OFFICER_NAME: MENDEZ, SUSANA

PROJECT_TERMS: Accounting;African ancestry;Automobile Driving;Bioinformatics;career;Cause of Death;cell type;Cells;Cessation of life;Clinical;clinical phenotype;cohort;Communicable Diseases;Complex Genetic Trait;Data;Data Set;Development;differential expression;Disease;Disease Management;Disease Outcome;Environment;Environmental Risk Factor;European;European ancestry;experience;Exposure to;Familiarity;Fellowship;flexibility;Flow Cytometry;Funding;Gene Expression;Gene Expression Profiling;Genes;Genetic;Genetic study;genetic variant;genome wide association study;Genomics;Genotype;genotyped patients;global health;Haplotypes;Heritability;Immune;immune function;Immune response;immunoregulation;improved;Individual;Infection;Infectious Agent;Inflammatory;interest;Knowledge;latent infection;Light;Link;Linkage Disequilibrium;Maps;Mediating;Mediation;Medicine;meetings;Mentorship;Messenger RNA;method development;Methodology;Methods;monocyte;mRNA sequencing;National Institute of Allergy and Infectious Disease;Neighborhoods;novel;Outcome;pathogen;Pathway interactions;Patients;Persons;Peru;Peruvian;Phenotype;Physiology;Population;power analysis;prevent;programs;progression risk;Research;resilience;Risk;simulation;single cell analysis;social factors;Source;Symptoms;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Therapeutic Effect;Tissues;Training;transcriptome;Tuberculosis;vaccine strategy;Vaccines;Validation;Variant;Work

PROJECT_TITLE: Characterizing the Genomic Basis of Immune-Mediated Resilience Against Tuberculosis in an Admixed Peruvian Population

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F08-M(20)L]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Clinical Research;Complementary and Integrative Health;Immunotherapy;Nutrition;Obesity;Prevention;Women's Health Research

ORG_CITY: IOWA CITY

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: Project Narrative Data obtained from this proposal are expected to establish A-FABP as a novel therapeutic target and biomarker for HFD-induced obesity/breast cancer risk. This proposal will not only have basic science ramifications for understanding how A-FABP shapes dysregulated lipid metabolism and functions of TAMs and breast cancer cells, but will also have significant clinical implications for prevention and immunotherapy of obesity-associated BC.

PI_NAMEs: LI, BING  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Address;Adipocytes;adiponectin;Adipose tissue;Affect;Basic Science;Breast;Breast Cancer Cell;Breast Cancer Patient;Breast Cancer Risk Factor;cancer clinical trial;cancer immunotherapy;cancer risk;Cellular Metabolic Process;Chronic;Clinical;cocoa butter;Collaborations;conditional knockout;Consumption;Data;design;Development;diet-induced obesity;epidemiology study;extracellular;FABP4 gene;Fatty acid glycerol esters;fatty acid-binding proteins;Fish Oils;Funding Opportunities;Health;High Fat Diet;Holden Comprehensive Cancer Center at the University of Iowa;Human;humanized antibody;Immune;Immunosuppression;Immunotherapy;improved;Inflammation;insight;Insulin;Interleukin-6;Knockout Mice;Leptin;Link;Linoleic Acids;lipid metabolism;Lipids;Macrophage;Malignant Breast Neoplasm;Mammary Neoplasms;Measures;Mediating;Metabolic;metabolic profile;Modeling;Molecular;Molecular Chaperones;Monoclonal Antibodies;monocyte;mortality;mouse model;Mus;new therapeutic target;novel;novel strategies;novel therapeutic intervention;Obesity;obesity biomarkers;Oleic Acids;Olive oil preparation;Omega-3 Fatty Acids;oxidation;Palmitic Acids;Pathway interactions;PDL1 pathway;Peripheral;Phenotype;Physician Executives;Postmenopause;Prevention;Prevention strategy;programs;Regulation;Research;response;Risk;Role;Sampling;saturated fat;Serum;Shapes;Source;Specimen;Therapeutic antibodies;therapeutic biomarker;Thinness;Tissues;Treatment Efficacy;tumor;tumor growth;Tumor-associated macrophages;tumorigenic;Unsaturated Fats;Woman;Xenograft procedure

PROJECT_TITLE: Determine the molecular and metabolic mechanisms by which A-FABP links  dysregulated lipid metabolism-induced obesity/breast cancer risk


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: The KL2 Core is an essential component of the Georgia Clinical & Translational Science Alliance (Georgia  CTSA) and designed to respond to the critical needs of training a new and diverse generation of clinical and  translational research (CTR) investigators who will carry out high impact research and translate new  discoveries to improve health for diverse communities. The KL2 Core will provide didactic and mentored CTR  training to a diverse group of junior faculty KL2 scholars and other trainees at the four partner Georgia CTSA  institutions (Emory University, Georgia Institute of Technology, Morehouse School of Medicine, and University  of Georgia). The KL2 Core also provides critical CTR training infrastructure at the Georgia CSTA partner  institutions through support of a Master of Science in Clinical Research (MSCR) program and a Certificate  Program in Translational Research (CPTR).

PI_NAMEs: BLUMBERG, HENRY M (contact);OFOTOKUN, IGHOVWERHA

PROGRAM_OFFICER_NAME: NAGEL, JOAN DAVIS

PROJECT_TERMS: Academy;Address;Area;Awareness;behavioral and social science;Biomedical Research;career;career development;certificate program;Clinical;Clinical Research;Collaborations;Communities;community engagement;Competence;COVID-19 pandemic;Data;Demography;design;Development;dissemination science;Doctor of Pharmacy;Doctor of Philosophy;education research;Educational Curriculum;Evaluation;evidence base;Faculty;flexibility;Foundations;Funding;Generations;Health;health disparity;health equity;health equity promotion;health inequalities;implementation science;improved;Influentials;innovation;Institution;instructor;Interdisciplinary Study;investigator training;Joints;Leadership;Link;Master of Science;Measures;Medicine;Mentored Clinical Scientist Development Program;Mentors;Mentorship;Morehouse School of Medicine;next generation;outcome disparities;Pathway interactions;Population;Population Heterogeneity;Positioning Attribute;professor;programs;recruit;Reporting;Research;Research Personnel;Research Training;Role;Science;skills;social science research;Solid;Structural Racism;Talents;Technology;TNFSF15 gene;Training;Training and Infrastructure;training opportunity;Training Programs;Translating;Translational Research;translational research program;Underrepresented Minority;Underrepresented Populations;Universities;virtual;Woman

PROJECT_TITLE: Institutional Career Development Core


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Genetics;Immunotherapy

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative: Defective DNA repair is a double-edged sword. It leads to increased genomic instability and accelerates tumor development and progression, but it also renders tumors more vulnerable to anti-cancer treatments, including inhibitors targeting immune checkpoints and cell cycle checkpoints. We propose to investigate essential DNA damage repair genes and pathways both in vitro and in vivo with the goal of exploiting these pathways and defects for cancer treatment.

PI_NAMEs: CHEN, JUNJIE  (contact)

PROGRAM_OFFICER_NAME: WITKIN, KEREN L

PROJECT_TERMS: Acceleration;Affect;anti-cancer treatment;BRCA mutations;cancer immunotherapy;Cancer Patient;cancer therapy;Cell Cycle Checkpoint;Cell Proliferation;Clinical Trials;CRISPR screen;Defect;design;Development;DNA Damage;DNA Repair;gene repair;Genes;Genomic Instability;Goals;immune checkpoint;Immune Targeting;improved outcome;In Vitro;in vivo;inhibitor;Knowledge;Mismatch Repair Deficiency;Mutation;novel therapeutics;Pathway interactions;Poly(ADP-ribose) Polymerase Inhibitor;Proliferating;Proteins;response;success;targeted cancer therapy;treatment strategy;tumor;tumor microenvironment;tumorigenesis

PROJECT_TITLE: Exploring DNA damage response pathways as targets for cancer therapy


ORG_NAME: BOSTON MEDICAL CENTER

PHR: Project Narrative Patients with chronic kidney disease (CKD) are at a higher risk for thrombosis and vascular complications after any vascular procedure, which can be potentially devastating. Over the last decade, our work identified uremic solutes (compounds that accumulate in the blood under compromised kidney function) as potent thrombogenic solutes. The current proposal delineates new mediators of this complication, and successful completion of this project may yield new biomarkers for thrombosis in CKD patients at risk, and may uncover new therapeutic targets.

PI_NAMEs: CHITALIA, VIPUL C (contact);RAVID, KATYA

PROGRAM_OFFICER_NAME: NEIDERT, LESLIE EAVES

PROJECT_TERMS: Address;Affect;American;Angioplasty;Animal Model;Arteries;Aryl Hydrocarbon Receptor;Biogenesis;Biological Markers;Blood;Blood Vessels;burden of illness;Cardiovascular Diseases;Carotid Artery Thrombosis;Cessation of life;Chronic Kidney Failure;Clinical;Clinical Trials;Complication;Coronary Thrombosis;cost;cytokine;Data;Dialysis procedure;Disease;Enzymes;Event;experience;Extracellular Matrix;Frequencies;Gene Silencing;Generations;Genetic;Hemostatic function;high risk;Human;human model;Indican;Inflammation;Inflammatory;inhibitor;innovation;Intervention;Investigation;ITIM;knockout gene;Knockout Mice;Kynurenine;Ligation;Mediating;Mediator;Modeling;Molecular;mortality;mouse model;Mus;new therapeutic target;novel;Operative Surgical Procedures;Organ;Pathology;Pathway interactions;Patients;PDGFRB gene;Persons;pharmacologic;Phosphorylation;Plasminogen Activator Inhibitor 1;Platelet-Derived Growth Factor beta Receptor;post intervention;Procedures;Production;Protein-Lysine 6-Oxidase;Proteins;Regulation;Renal function;Research;Risk;Risk Factors;Signal Transduction;solute;therapeutic target;thrombogenesis;Thromboplastin;Thrombosis;thrombotic;Time;Toxic effect;Toxin;trend;Tryptophan;Tryptophan 2,3 Dioxygenase;Tyrosine;ubiquitin-protein ligase;Up-Regulation;Uremia;vascular injury;Veins;Venous Thrombosis;Work

PROJECT_TITLE: Disease-specific risk factors for thrombosis following vascular interventions

STUDY_SECTION: HTBT

STUDY_SECTION_NAME: Hemostasis, Thrombosis, Blood Cells and Transfusion Study Section[HTBT]