ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Prevention;Social Determinants of Health;Suicide;Suicide Prevention;Violence Research

ORG_DEPT: PSYCHIATRY

ORG_NAME: UNIVERSITY OF ROCHESTER

ORG_STATE: NY

PHR: Older adults have high rates of suicide yet there are no evidence-based interventions to prevent suicide deaths in later life. Social disconnection is a promising intervention target for late-life suicide prevention, but it is not known whether targeting social connection is an effective strategy to prevent suicide in later life. This study will test whether Social Engage Coaching (10 sessions of coaching to increase social connection) reduces suicide risk in later life (clinical outcome) via social connection (target mechanism).

PI_NAMEs: VAN ORDEN, KIMBERLY ALLISON (contact)

PROGRAM_OFFICER_NAME: EVANS, JOVIER D

PROJECT_TERMS: Address;Age;arm;Behavior;Behavior Therapy;Cellular Phone;Cessation of life;Clinical;cohort;community living;confirmatory trial;Data;Depressive disorder;Dimensions;disability;Disease;Ecological momentary assessment;efficacy trial;Elements;Emotional;Evidence based intervention;experience;Exposure to;Feeling suicidal;firearm access;follow-up;Goals;Health;Home;improved;in vivo;indexing;Individual;Intervention;Intervention Studies;Investigational Therapies;Laboratories;late life;Link;Loneliness;Measures;Mental Depression;Mental Health;Modeling;multimodality;National Institute of Mental Health;older adult;Outcome;Patient Self-Report;peer;Personal Satisfaction;Phase;Physician Executives;Population;prevent;Protocols documentation;Provider;Quality of life;randomized trial;reducing suicide;Risk Factors;satisfaction;Severities;social;Social Conditions;social engagement;Social isolation;Social Planning;Standardization;suicidal morbidity;suicidal risk;Suicide;Suicide prevention;suicide rate;Testing;Thinking;Time;treatment as usual;United States National Institutes of Health

PROJECT_TITLE: Promoting Social Connection to Prevent Late-Life Suicide


ADMINISTERING_IC: AI

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: PHILADELPHIA

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: WISTAR INSTITUTE

ORG_STATE: PA

PHR: Overall Narrative Building on progress from our previous IPCAVD, the goal of this program is to advance DNA launched nanoparticles bearing native like trimers which focus immune responses on apex and CD4bs B cell lineage targeted Envs (DLNP-ACE). Combining these novel immunogens with DNA- delivered genetic adjuvants to support vaccine-induced immunity represents a great leap forward in the design of HIV-1 vaccines. We have assembled an innovative team of experts in HIV vaccine immunogen design, DNA vaccine delivery, immune analysis, and infection models, and combined them with a clinical program partner, Inovio pharmaceuticals, which has extensive experience in cGMP production and clinical translation of DNA products.

PI_NAMEs: WEINER, DAVID B. (contact)

PROGRAM_OFFICER_NAME: VIJH, SUJATA

PROJECT_TERMS: adenosine deaminase;Adjuvant;Adoptive Transfer;Advanced Development;Agreement;Animal Model;Antibodies;Antibody Repertoire;Antibody Response;Antigens;Apical;Asia;B-Lymphocytes;Binding Sites;candidate selection;CD8-Positive T-Lymphocytes;Cell Lineage;Cell Physiology;Cellular Immunity;cGMP production;Clinic;Clinical;clinical development;Clinical Protocols;Clinical Research;clinical translation;Clinical Trials;clinically relevant;Collaborations;Complex;Cyclic GMP;cytokine;design;Development;Development Plans;Devices;DNA;DNA delivery;DNA Vaccines;effector T cell;Electroporation;Epitopes;Europe;experience;Genetic;Germ Lines;global health;Goals;Helper-Inducer T-Lymphocyte;HIV;HIV Antigens;HIV vaccine;HIV Vaccine Trials Network;HIV-1;Human;Humoral Immunities;Immune;Immune response;Immunity;immunogenic;immunogenicity;Immunoglobulin G;in vivo;Infection;innovation;Interleukin-12;interleukin-21;International;Investigation;Knock-in Mouse;lead candidate;Macaca mulatta;manufacture;manufacturing facility;member;Modeling;Molecular;Mucous Membrane;Mus;nanoparticle;Needles;neutralizing antibody;next generation;nonhuman primate;novel;novel strategies;novel vaccines;Nucleic Acids;Other Genetics;pandemic disease;Peripheral;Pharmacologic Substance;Phase;phase 3 study;Phenotype;Plasmids;pre-clinical;Prevention strategy;Primates;Process;Production;programs;promoter;Proteins;Reporting;response;Serum;simian human immunodeficiency virus;Skin;Structure;Structure of germinal center of lymph node;synthetic construct;T cell response;T-Lymphocyte;Technology;tool;Translations;vaccine delivery;Vaccine Design;vaccine development;vaccine trial;vaccine-induced immunity;Vaccines;Work

PROJECT_TITLE: Synthetic DNA-launched and adjuvanted Env immunogens for HIV


NIH_SPENDING_CATS: Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adjuvant;Animals;Antigens;Attention;Clinical Trials;Communication;conflict resolution;Data Reporting;DNA;Ensure;experience;Feedback;Financial Support;Funding;Goals;HIV;HIV Vaccine Trials Network;Human Resources;Industry;Intellectual Property;Leadership;meetings;member;Mission;Monitor;Office of Administrative Management;open data;Outcome;Performance;Plasmids;Primates;product development;Production;Program Reviews;programs;Progress Reports;Publications;Reporting;Research;Resources;Sampling;Schedule;Site;synthetic construct;Time;United States National Institutes of Health;Update;video chat;Work;working group;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PROJECT_TERMS: Adjuvant;Antibodies;Antibody Response;Antigens;Apical;Automobile Driving;B-Lymphocytes;Benchmarking;Binding Sites;CCL27 gene;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Lineage;Cells;Cellular Immunity;Clinic;Clinical;Clinical Trials;Complex;Conceptions;design;Development;DNA;DNA Vaccines;Dose;effector T cell;Epitopes;Evaluation;Formulation;Frequencies;Genetic;Goals;HIV;HIV vaccine;HIV Vaccine Trials Network;HIV-1;HIV-1 vaccine;Human;Humoral Immunities;immune function;Immune response;Immunity;Immunization;immunogenicity;in vivo;Interleukin-12;interleukin-21;Knock-in Mouse;Laboratories;Mediating;Molecular;Mucous Membrane;Mus;nanoparticle;neutralizing antibody;novel;Plasmids;Population;programs;Property;Regimen;Reporting;response;Selection Criteria;self assembly;Surface;synthetic construct;T cell response;T-Lymphocyte;Tissues;Vaccinated;vaccine candidate;vaccine immunogenicity;vaccine-induced immunity;Vaccines

PROJECT_TITLE: Design and optimization of DL-NLTs and molecular adjuvants to increase potency and promote NAb formation in vivo


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Understanding the biological role and underlying mechanisms of genetic risk factors in neural development will allow for more targeted therapeutic interventions for neurodevelopmental and neurological disorders. Combining animal models with novel human stem cell culture systems provides a new platform for the study of fundamental processes of human brain development and rational intervention.

PI_NAMEs: MING, GUO-LI  (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Adult;adult neurogenesis;Affect;Animal Model;Behavior;Biological;Biology;Brain;Brain Diseases;cell behavior;Cell Culture System;Cell Physiology;Cell Reprogramming;Cells;Copy Number Polymorphism;design;Development;Diagnosis;differentiation protocol;Disease;DNA Sequence Alteration;Environmental Risk Factor;Event;Generations;Genetic;Genetic Risk;genetic risk factor;Genetic Variation;Goals;Human;Human Development;human induced pluripotent stem cells;human stem cells;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;induced pluripotent stem cell technology;Intervention;Knowledge;Measures;Molecular;mouse model;Mus;nerve stem cell;Nervous System Disorder;neural;neural model;neurodevelopment;Neurodevelopmental Disorder;neurogenesis;neuromechanism;neuron development;Neurons;Neurophysiology - biologic function;novel;Patients;prevent;Process;programs;Research;Resolution;Resources;Risk;Risk Factors;risk variant;Role;stem cell biology;synaptogenesis;targeted treatment;technological innovation;Technology;Testing;Therapeutic Intervention;three dimensional cell culture;Tissues;tool;transcriptome;Transgenic Mice

PROJECT_TITLE: Functional roles of genetic risk factors for brain disorders in neurogenesis and neurodevelopment


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: The proposed research is relevant to NEI mission because it studies fundamental circuit mechanisms that are involved in the visual perception. Our work will provide novel theoretical and empirical approaches to understand neuronal function in and beyond the retina.

PI_NAMEs: POLEG-POLSKY, ALON  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Behavior;Biological Models;Biophysics;Brain;Calcium;Calcium Signaling;Cell Physiology;Cells;Complex;Conscious;Data;Dendrites;Detection;Discrimination;Distal;Electrophysiology (science);experimental study;Formulation;ganglion cell;Generations;Glutamates;Goals;Guidelines;Image;imaging approach;improved;Individual;information processing;innovation;Investigation;Literature;Measurement;Measures;Mediating;Methodology;Mission;Modeling;Morphology;Motion;neural;neuronal cell body;Neurons;novel;novel strategies;Output;Perception;Pharmacology;Phase;Photic Stimulation;Photoreceptors;Physiological;Population;postsynaptic;Potassium Channel;preference;presynaptic;Process;Property;receptive field;Research;response;Retina;Role;Shapes;signal processing;Signal Transduction;simulation;Site;starburst amacrine cell;Stimulus;Synapses;System;Testing;Time;transmission process;Visual;visual information;Visual Perception;visual processing;Visual System;voltage gated channel;Work

PROJECT_TITLE: Mechanisms of direction selectivity in starburst amacrine cells

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Nanotechnology;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: KULP, DANIEL  (contact)

PROJECT_TERMS: acronyms;Address;Adjuvant;Adoptive Transfer;Affinity;Animal Model;Animals;Antibodies;Antibody Repertoire;Antigens;Apical;Artificial nanoparticles;B-Lymphocytes;Benchmarking;Binding;Binding Sites;Cell Lineage;cell type;Clinic;clinical development;Complex;Cryoelectron Microscopy;Cyclic GMP;design;Development;Directed Molecular Evolution;DNA;DNA Structure;Electron Microscopy;Engineering;Epitope Mapping;Epitopes;Formulation;Frequencies;Genes;Genetic;Germ Lines;global health;Glycoproteins;Goals;HIV;HIV vaccine;HIV-1;HIV-1 vaccine;Human;Immune;Immunity;Immunization;immunogenic;immunogenicity;improved;In Vitro;in vivo;Individual;innovation;Investigation;Knock-in Mouse;Laboratories;lead candidate;lead optimization;lead series;Maps;Measures;Methods;Modality;Modeling;Modification;Molecular;Monitor;mouse model;Mus;Mutation;nanoparticle;neutralizing antibody;nonhuman primate;novel;Pathway interactions;Pattern;Plasma;pre-clinical;Primates;Process;Production;programs;prophylactic;Protein Subunits;Protocols documentation;Publications;Recombinants;Recurrence;Reporting;response;Rhesus;simian human immunodeficiency virus;Somatic Mutation;Structure;Structure of germinal center of lymph node;Subunit Vaccines;Surface;synthetic construct;Techniques;Testing;Time;trafficking;vaccine candidate;Vaccine Design;vaccine strategy;vaccine trial;Vaccines;Variant;Virus;Virus Diseases

PROJECT_TITLE: Refinement of DNA-Launched NanoParticles decorated with Apex and CD4bs B cell lineage targeting Envs (DLNP-ACEs)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Foodborne Illness;Infectious Diseases;Orphan Drug;Pediatric;Rare Diseases

ORG_CITY: SEATTLE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: NARRATIVE: Optimization of Lead BKIs for Cryptosporidiosis Therapy The long-term objective of this research is to develop a new therapeutic for treatment of Cryptosporidium infection, which causes death and severe disease in malnourished children in resource-limited countries and immunocompromised individuals in the USA. In this proposal, we will rationally develop a drug with favorable properties that can serve as treatment of Cryptosporidium in the target population of malnourished children and immunocompromised individuals. At the end of the grant period, we expect to have a drug candidate that is ready to move towards human trials for therapy of cryptosporidiosis.

PI_NAMEs: VAN VOORHIS, WESLEY C (contact)

PROGRAM_OFFICER_NAME: JOY, DEIRDRE A

PROJECT_TERMS: 3-Dimensional;Address;Animals;Back;Blood Chemical Analysis;bone;calcium-dependent protein kinase;Canis familiaris;Cardiac;Cardiovascular system;Cause of Death;Characteristics;Child;Chondrocytes;Clinical;Country;Cryptosporidiosis;Cryptosporidium;Cryptosporidium parvum;cytotoxicity;design;Development;Diarrhea;Disease;dosage;Dose;drug candidate;Drug Kinetics;Dysplasia;efficacy testing;Embryonic Development;Fetal Development;Fetal safety;Grant;Growth;Hemorrhage;Histopathology;Human;Immunocompromised Host;Impairment;improved;In Vitro;in vivo;Individual;Infection;inhibitor therapy;Interferon Type II;kinase inhibitor;Knockout Mice;Lead;lead optimization;Malnutrition;Mammalian Cell;manufacture;manufacturing scale-up;MAP2K1 gene;Metabolic Pathway;Modeling;Morbidity - disease rate;mortality;motility disorder;Mus;Neurologic;Newborn Infant;nitazoxanide;novel;novel therapeutics;Oral;Outcome;pathogen;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phosphotransferases;Plasma;Polymorph;porcine model;pre-clinical;Predisposition;Pregnancy;programs;Property;Rattus;Research;Resources;response;Safety;safety study;safety testing;Sampling;screening;Solubility;Structure-Activity Relationship;Symptoms;Target Populations;Testing;Therapeutic;Therapy trial;Toxic effect;Toxicity Tests;Toxicology;Vaccines;Zebrafish

STUDY_SECTION: DDR

STUDY_SECTION_NAME: Drug Discovery and Mechanisms of Antimicrobial Resistance Study Section[DDR]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Mental Health;Neurosciences

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE PUBLIC HEALTH RELEVANCE: Abnormal repetitive thoughts and behaviors are prominent, disabling, and notoriously-treatment resistant symptoms of many severe and highly comorbid childhood onset neuropsychiatric disorders such as Obsessive Compulsive Disorder (OCD), Tourette Syndrome (TS), and autism. However, we still have a quite limited understanding of how these maladaptive behaviors are encoded in the brain. Defining the contribution of supplementary and pre-supplementary motor cortical regions to the generation and execution of perseverative thought patterns and repetitive actions may help develop new strategies for prevention and optimize existing neurostimulation protocols for these symptoms.

PI_NAMEs: AHMARI, SUSANNE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Anterior;Anterolateral;Area;autism spectrum disorder;Behavior;Behavioral;Brain;Brain region;Childhood;Color;comorbidity;Complex;Corpus striatum structure;Data;defined contribution;Detection;Disabling;Drops;Electrophysiology (science);Fiber;Generations;Gilles de la Tourette syndrome;Goals;Grooming;Homologous Gene;Human;Hyperactivity;Image;in vivo;Individual;Instinct;Knock-out;Knockout Mice;Lateral;learned behavior;Length;Link;maladaptive behavior;Microscopy;Modeling;Motor;Motor Cortex;motor learning;Movement;Neurons;neuropsychiatric disorder;novel;Obsessive-Compulsive Disorder;optogenetics;Pattern;Performance;Photometry;Play;Preparation;Prevention strategy;Process;programs;Property;Protocols documentation;public health relevance;Ramp;recruit;Regulation;Resistance;Rodent;Role;sequence learning;serial imaging;Slice;stem;Stereotyping;Symptoms;System;Testing;theories;Thinking;Wild Type Mouse;Work

PROJECT_TITLE: Investigating the role of anterior lateral motor cortex in control and execution of sequenced behaviors

STUDY_SECTION: BRLE

STUDY_SECTION_NAME: Biobehavioral Regulation, Learning and Ethology Study Section[BRLE]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Aging;Bioengineering;Brain Disorders;Cerebrovascular;Disability Research;Neurosciences;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Stroke

ORG_CITY: DURHAM

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Narrative Stroke is the leading cause of adult disability and no current treatments exist beyond physical therapy. This proposal explores the mechanism of action of a biomaterial based therapy to promote recovery after stroke aiming to reduce stroke induced disability. Understanding the mechanism of action will provide new therapeutic targets to further improve recovery and reduce disability after stroke.

PI_NAMEs: SEGURA, TATIANA  (contact)

PROGRAM_OFFICER_NAME: BOSETTI, FRANCESCA

PROJECT_TERMS: Adult;Affect;age related;angiogenesis;Animal Model;Anti-Inflammatory Agents;Applications Grants;Astrocytes;Axon;axon growth;axonal sprouting;Behavioral;behavioral outcome;Biocompatible Materials;Biomedical Engineering;Blood flow;Brain;Brain Injuries;brain repair;brain tissue;Cell Death;Cells;Cellular Infiltration;Cerebral Ischemia;Chronic;Cicatrix;clinical translation;clinically relevant;crosslink;cytokine;Development;disability;disability burden;disabling disease;Dose;Endothelial Cells;Engineering;Environment;Ephrins;Experimental Designs;Experimental Models;Extracellular Matrix;Formulation;functional improvement;Funding;Generations;Goals;Growth Cones;Heparin;Heparin Binding;Hyaluronic Acid;Hydrogels;Image;Immune;Immune response;improved;In Situ;Infarction;Infiltration;Inflammation;Inflammatory;Injectable;Injections;Injury;Integrin Binding;Integrins;interest;Interruption;Ischemic Stroke;Lead;Ligands;Link;Liquid substance;Macrophage;Magnetic Resonance Imaging;Messenger RNA;Methodology;Mus;nanoparticle;Natural regeneration;Necrosis;necrotic tissue;Nervous System Physiology;neurogenesis;Neuroglia;Neurologic;Neurologic Deficit;neurological recovery;Neuronal Plasticity;Neurons;neurovascular;new therapeutic target;novel therapeutics;old mice;Patients;Physical therapy;Population;post stroke;Production;programs;Proteins;Recovery;Recovery of Function;regenerative;repaired;revascularization;Signal Pathway;Signal Transduction;skin wound;Stroke;stroke model;stroke patient;stroke therapy;Stromal Cell-Derived Factor 1;Survival Rate;synergism;Technology;Testing;Therapeutic;therapeutic angiogenesis;Time;tissue regeneration;tissue repair;Tissues;transcriptome;Vascular Endothelial Growth Factors;Vascularization

PROJECT_TITLE: VEGF ligand presentation and therapeutic angiogenesis

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: HOUSTON

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

ORG_STATE: TX

PHR: Dysregulation of the switching function of GTP hydrolyzing lipid-anchored signaling proteins, particularly those in the Ras superfamily, leads to intractable diseases including cancer, developmental disorders, and lysosomal and celiac diseases. There is need for effective drugs that directly act on these proteins. The proposed work intends to uncover novel therapeutic opportunities for this class of proteins focusing on their dynamics on membrane surfaces.

PI_NAMEs: GORFE, ALEMAYEHU A. (contact)

PROGRAM_OFFICER_NAME: NIE, ZHONGZHEN

PROJECT_TERMS: Adopted;Affect;Binding;Biological Assay;Biological Models;Biophysics;Catalytic Domain;Celiac Disease;cell growth;Cell membrane;Cell Physiology;Cells;confocal imaging;Data;Development;developmental disease;Disease;Distal;effective therapy;Electron Microscopy;Electrostatics;experience;experimental study;Family;Family member;flexibility;fluorophore;Foundations;Functional disorder;GTP Binding;Guanosine Triphosphate;Human;Human Genome;Hydrophobicity;insight;KRAS2 gene;Label;Lipids;Lysosomal Storage Diseases;Malignant Neoplasms;Maps;Mediating;Membrane;membrane model;Modification;Molecular;Molecular Conformation;molecular dynamics;monomer;Monomeric GTP-Binding Proteins;Motility;Mutation;Mutation Analysis;N-terminal;nanodisk;novel;novel therapeutics;Organizational Productivity;overexpression;Peripheral;Pharmaceutical Preparations;Protein Family;protein structure;Proteins;RAS genes;ras Proteins;rho;Role;Signal Transduction;Signaling Protein;simulation;single-molecule FRET;Site;spatiotemporal;structural determinants;Surface;Techniques;Tertiary Protein Structure;Testing;trafficking;Work

PROJECT_TITLE: Dynamics of lipid-anchored proteins

STUDY_SECTION: MSFD

STUDY_SECTION_NAME: Macromolecular Structure and Function D Study Section[MSFD]


ADMINISTERING_IC: AR

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

ORG_CITY: PORTLAND

ORG_DEPT: DERMATOLOGY

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PUBLIC HEALTH RELEVANCE STATEMENT The Montagna Symposium on the Biology of Skin is a conference that has existed for nearly 70 years and creates a unique forum for researchers and physicians to discuss the latest scientific progress on aspects of skin biology that inform about the causes of skin disease. This conference brings together a diverse mix of health professionals and researchers from different fields whose multi-disciplinary interactions are needed to strategize and take action to develop new treatments for diseases involving skin. Over time, many breakthroughs in skin research discussed at the Montagna Symposium have shaped whole fields in science and medicine and the Symposium has also been a key career development step for young researchers and clinicians-in-training to meet and learn from renowned scientific leaders.

PI_NAMEs: LEACHMAN, SANCY ANN (contact);ROOP, DENNIS

PROGRAM_OFFICER_NAME: KOCH, PETER

PROJECT_TERMS: Address;Anniversary;Atmosphere;Award;Back;Basic Science;Biological;Biology;Body System;career;career development;Clinical;Clinical Investigator;Collaborations;Colorado;Communication;Communities;cost;COVID-19 pandemic;Cutaneous;Dermatologist;Dermatology;design;Diagnosis;Discipline;Disease;Doctor of Philosophy;Dreams;Equilibrium;Fees;Fostering;Foundations;Funding;Future;Goals;Grant;grasp;Health;Health Professional;Human;Human Biology;Human body;human disease;innovation;innovative technologies;Journals;Knowledge;Learning;Medical;medical specialties;Medicine;meetings;Mission;Molecular;multidisciplinary;National Institute of Arthritis, and Musculoskeletal, and Skin Diseases;next generation;novel;Oregon;Organ;Paper;Participant;Patient Care;Peer Review;Persons;Pharmacologic Substance;Physicians;Production;programs;Property;public health relevance;Publications;Regulation;Research;Research Personnel;Resort;Running;Science;science and society;Scientific Advances and Accomplishments;Scientist;Shapes;Skin;skin color;skin disorder;Source;Specialist;Structure;symposium;Techniques;Time;tissue resident memory T cell;Training;translational potential;Travel;United States National Institutes of Health;Visualization;waiver;Work

STUDY_SECTION: AMS

STUDY_SECTION_NAME: Arthritis and Musculoskeletal and Skin Diseases Special Grants Study Section[AMS]


ADMINISTERING_IC: HL

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Heart Disease;Hematology;Transplantation

ORG_CITY: CHAPEL HILL

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: PROJECT NARRATIVE This project will use experimentally and clinically validated computer models to understand the mechanisms that lead to subclinical leaflet thrombosis in bioprosthetic heart valves following aortic valve replacement, and thereby improve risk stratification and device selection for patients who require aortic valve replacement to treat aortic stenosis.

PI_NAMEs: FOGELSON, AARON L;GRIFFITH, BOYCE EUGENE (contact);KHERADVAR, ARASH

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Acceleration;Acute myocardial infarction;Address;Age;aging population;Anatomy;Anticoagulation;Aorta;aortic valve;aortic valve replacement;Aortic Valve Stenosis;Biochemical;Biophysics;Bioprosthesis device;Blood Cell Count;Blood Coagulation Factor;Blood flow;Blood Platelets;Blood Vessels;Clinical;Clinical Data;clinical imaging;Clinical Research;clinically actionable;Coagulation Process;Collaborations;Competence;Complication;computational platform;Computer Models;Coupled;Data;Deposition;Deterioration;Device Designs;Devices;effective therapy;Experimental Models;follow-up;four-dimensional computed tomography;Goals;Guidelines;Heart Valves;Image;Impact evaluation;Impairment;implantable device;implantation;improved;improved outcome;In Vitro;Incidence;Injury;innovation;Lead;Liquid substance;Mathematics;Measurement;Methods;Modeling;multidisciplinary;novel;older patient;open source;Operative Surgical Procedures;Oral;Outcome;particle;Patient imaging;Patient Selection;Patients;Pattern;physical model;Physiologic pulse;platelet function;predictive modeling;preference;prevent;Prosthesis;Quantitative Evaluations;Randomized;Recommendation;Risk;Risk Assessment;risk stratification;Role;Severities;simulation;Software Framework;Stents;Stroke;Structure;Thrombosis;Transient Ischemic Attack;treatment planning;Validation;valve replacement;Velocimetries;Work

PROJECT_TITLE: Computational and Experimental Modeling of Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Prevention;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: The promise of personalized cancer therapy will only be realized when the full impact of each patient's variants can be fully understood. Our proposal aims at taking advantage of the recent rapid accumulation of omics data and leveraging our expertise in PDX and genetic models, along with experience in single cell omics, to address a number of unanswered questions related to cancer predisposition. Results from this project will impact both the fundamental biological questions regarding cancer predisposition and practical clinical questions regarding genetic counseling and treatment choices with considerations to the origins of variants/ mutations in the cancer driver genes.

PI_NAMEs: CHEN, FENG ;DING, LI  (contact)

PROGRAM_OFFICER_NAME: LI, JERRY

PROJECT_TERMS: Address;ATAC-seq;Biological;brca gene;Breast Cancer Cell;Breast Cancer Model;cancer cell;cancer predisposition;cancer type;cell stroma;Cells;Characteristics;Clinical;Clonality;Computer Analysis;Data;Development;differential expression;Event;experience;Genes;Genetic Counseling;Genetic Models;Genetic Models for Cancer;Genetic Transcription;Germ Lines;Germ-Line Mutation;Human;human imaging;Image;Immune;improved;Incidence;Malignant Neoplasms;Modeling;Molecular;mouse genetics;mouse model;multiple omics;multiplexed imaging;Mutation;Nature;neoplastic cell;Oncogene Activation;Oncogenes;Oncogenic;patient derived xenograft model;Patient-derived xenograft models of breast cancer;Patients;Pattern;personalized cancer therapy;Phenotype;Predisposition;pressure;Process;Prognosis;Proteins;Proteomics;Renal Carcinoma;Renal Cell Carcinoma;Resolution;response;Role;Sampling;Signal Transduction;single cell analysis;single nucleus RNA-sequencing;Somatic Mutation;Susceptibility Gene;Testing;Tissue-Specific Gene Expression;Tissues;Transcend;transcriptomics;translational impact;treatment choice;treatment response;tumor;tumor initiation;tumor microenvironment;tumor progression;Tumor Suppressor Proteins;tumorigenesis;Variant

PROJECT_TITLE: Impact of cancer predisposition on oncogenic process, microenvironment, and treatment

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


ORG_CITY: BETHESDA

ORG_NAME: HENRY M. JACKSON FDN FOR THE ADV MIL/MED

ORG_STATE: MD

PHR: PROJECT NARRATIVE The proposed research will elucidate new biochemical and metabolic checkpoints involved in regulating T cell death, focusing on the function of several molecules with potential diagnostic and therapeutic value in regulating the magnitude of a given T cell response. Defining these pathways will help us better understand, predict, and potentially control immune responses in situations where increasing or decreasing T cell numbers would be beneficial. Therefore, this research is broadly relevant to public health and numerous clinical settings in which the potency of the T cell-directed immune response is directly related to disease severity and outcome.

PI_NAMEs: SNOW, ANDREW L (contact)

PROGRAM_OFFICER_NAME: CHAO, CHIEN-CHUNG

PROJECT_TERMS: Autoimmunity;B-Lymphocytes;Binding;Biochemical;Cell Count;Cell Death;Cell Death Induction;Cessation of life;Clinical;Defect;Diagnostic;Disease;Disease Outcome;Equilibrium;Event;FOXP3 gene;Genetic;Genetic Transcription;Homeostasis;Human;Immune;Immune response;Immune system;Immune System Diseases;improved;Infection;interest;Learning;Leukocytes;Lymphoproliferative Disorders;Malignant Neoplasms;Metabolic;Metabolism;Molecular;new therapeutic target;novel;NTB-A;pathogen;Pathway interactions;Patients;Phosphoric Monoester Hydrolases;Phosphotransferases;Play;Predisposition;Process;programs;Proliferating;PTPN6 gene;Public Health;receptor;Receptor Signaling;Regulation;Regulatory T-Lymphocyte;Research;Role;Severity of illness;SH2D1A gene;Signal Transduction;Signaling Molecule;Single-Gene Defect;T cell response;T-Cell Activation;T-Cell Proliferation;T-Cell Receptor;T-Lymphocyte;Therapeutic;Tissues;transcription factor;Vaccination;X-Linked lymphoproliferative disorders

PROJECT_TITLE: Temporal and Metabolic Regulation of Restimulation-Induced Cell Death (RICD) in Human T Cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;HIV/AIDS;Immunization;Infectious Diseases;Prevention;Vaccine Related;Vaccine Related - AIDS

PI_NAMEs: SMITH, TREVOR  (contact)

PROJECT_TERMS: Adjuvant;Advanced Development;Animal Model;Animals;Antigens;Asia;Cavia;Charge;Clinical;Clinical Research;Clinical Trials;clinically relevant;Collaborations;Coupled;Cyclic GMP;cytokine;Dedications;design;Development;Devices;DNA;DNA Vaccines;Dose;Drug Delivery Systems;Electroporation;Europe;Evaluation;experience;Goals;Guidelines;HIV;HIV Antigens;HIV vaccine;HIV Vaccine Trials Network;Human;Immune response;immunogenicity;in vivo;Interleukin-12;International;Intramuscular;manufacture;manufacturing facility;Mediating;minimally invasive;Modeling;next generation;novel;Persons;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 3 study;plasmid DNA;Plasmids;portability;preclinical development;preclinical study;Process;product development;Production;Program Development;programs;promoter;Protocols documentation;Research;research clinical testing;Research Support;Running;scale up;Skin;synergism;synthetic construct;Technology;technology platform;vaccine delivery;vaccine development;Vaccines;Vial device;Work

PROJECT_TITLE: Vaccine and adjuvant Clinical GMP product development and DNA Technology platform enhancements


NIH_SPENDING_CATS: Genetics;Human Genome;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Regenerative Medicine;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROLOGY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE There are no effective treatments for spinal cord injury (SCI). The financial and emotional burden these injuries have on patients and their families highlights the urgent clinical need for maximally adaptive and minimally maladaptive potent repair strategies. The aim of this proposal is to explore the molecular machinery that drives rehabilitation mediated recovery of function after SCI and determine whether this intrinsically mediated axon growth program can be exploited to more comprehensively restore function after severe acute and chronic SCI.

PI_NAMEs: CAFFERTY, WILLIAM B. (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Adult;Affect;Anatomy;Atlases;Automobile Driving;Axon;axon growth;Cells;Central Nervous System;Cervical spinal cord structure;Chronic;Clinical;Contralateral;Corticospinal Tracts;Data;Data Set;design;Disease;Dissociation;effective therapy;Embryo;Emotional;experience;Family;Foundations;functional plasticity;functional restoration;Gene Expression Profiling;Genes;genetic signature;Genetic Transcription;Geometry;Goals;Growth;Growth Inhibitors;Harvest;human induced pluripotent stem cells;In Vitro;in vivo;Injury;injury burden;inositol-1,4,5-trisphosphate 5-phosphatase;Intervention;Label;Lesion;lipid phosphate phosphatase;Location;Lumbar spinal cord structure;Mediating;Modeling;Molecular;Molecular Target;Mus;Myelin;Natural regeneration;Neurons;novel;novel therapeutics;Optic Nerve;Pathway interactions;patient prognosis;Patients;Phenotype;Population;prevent;programs;Proteins;receptor;Recovery;Recovery of Function;Rehabilitation therapy;repair strategy;repaired;Research;Research Personnel;response;Retinal Ganglion Cells;single-cell RNA sequencing;Specificity;Spinal;Spinal cord damage;Spinal cord injury;synergism;Therapeutic;Therapeutic Intervention;Tissue-Specific Gene Expression;Tissues;Titrations;Training;transcriptome;transcriptome sequencing;Trauma;Viral;Wild Type Mouse

PROJECT_TITLE: Defining and exploiting the plasticity transcriptome to repair the damaged spinal cord

STUDY_SECTION: CNNT

STUDY_SECTION_NAME: Clinical Neuroplasticity and Neurotransmitters Study Section[CNNT]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Breast Cancer;Cancer;Machine Learning and Artificial Intelligence;Prevention;Women's Health Research

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

PHR: Over ten million women each year receive a notification letter informing them that they have dense breast tissue and that they should consider having supplemental screening with ultrasound or MRI. Unfortunately, there is insufficient information available to help women determine whether the benefits for them as an individual outweigh the known harms of getting supplemental screening. Our research goal is to develop a technique that can detect breast cancers missed on screening digital breast tomosynthesis images in women with dense breast tissue, and thus giving women additional information to help them make better informed decisions regarding supplemental screening.

PI_NAMEs: LEE, JUHUN  (contact)

PROGRAM_OFFICER_NAME: FU, SIDNEY WANG

PROJECT_TERMS: 3-Dimensional;Area;artificial intelligence method;base;biomarker validation;Biopsy;Breast;Breast Cancer Detection;Breast Cancer Risk Factor;breast density;breast imaging;Breast Magnetic Resonance Imaging;Cancer Detection;Clinical;Consult;convolutional neural network;cost;Data Set;Development;digital;Digital Breast Tomosynthesis;Digital Mammography;Financial cost;Future;Goals;high risk;Image;imaging biomarker;imaging facilities;Imaging Techniques;Individual;Lateral;Laws;Lead;Left;Letters;Magnetic Resonance Imaging;Malignant Breast Neoplasm;Malignant Neoplasms;Mammary Gland Parenchyma;Mammographic screening;Mammography;Methods;Modality;Modeling;Notification;novel;Physicians;Process;Radon;Recommendation;Research;Research Personnel;Risk;ROC Curve;Scanning;screening;Sensitivity and Specificity;Signal Transduction;Slice;Specificity;supplemental screening;Target Populations;Techniques;Testing;Thick;Three-Dimensional Imaging;Tissues;tomosynthesis;Training;Translating;ultrasound;Validation;Woman

PROJECT_TITLE: Detecting Mammographically-Occult Cancer in Women with Dense Breasts Using Digital Breast Tomosynthesis

STUDY_SECTION: EITA

STUDY_SECTION_NAME: Emerging Imaging Technologies and Applications Study Section[EITA]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Genetics;Human Genome;Women's Health Research

ORG_CITY: DALLAS

ORG_DEPT: PATHOLOGY

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: Project Narrative Histone subunit post-translational modification (PTM), including methylation and acetylation, regulates gene expression and epigenetic regulation in cancer. Here we provide evidence that a novel H3 hydroxylation on Pro16 by EglN2 prolyl hydroxylase leads to increased KDM5A histone demethylase binding on H3, decreased H3K4me3 and gene expression in breast cancer cells. Our study will provide the mechanistic insight on how this new H3 PTM contributes to epigenetic regulation and gene expression in breast cancer.

PI_NAMEs: ZHANG, QING  (contact)

PROGRAM_OFFICER_NAME: OKANO, PAUL

PROJECT_TERMS: Acetylation;Affect;angiogenesis;Antibodies;ARNT gene;beta catenin;Binding;Breast Cancer Cell;Breast Cancer cell line;Breast Cancer Patient;Breast Epithelial Cells;C-terminal;cancer cell;Cell Proliferation;Cells;Characteristics;Cleavage Under Targets and Release Using Nuclease;clinically relevant;Complex;Data;demethylation;Detection;Dimerization;Disease;Enzymes;Epigenetic Process;epigenetic regulation;Event;Family member;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;genome-wide;Genomics;Growth Inhibitors;Histone Code;histone demethylase;Histone H3;histone modification;Histones;Hydroxylation;Hypoxia;Hypoxia Inducible Factor;In Vitro;in vivo;inhibitor;insight;Lead;Lysine;Malignant - descriptor;Malignant Breast Neoplasm;Malignant Neoplasms;Measures;Mediating;Metabolism;Methylation;Mixed-Lineage Leukemia;Modeling;Modification;Molecular;novel;Oncogenic;Oxygen;Phosphorylation;Play;Post-Translational Protein Processing;Procollagen-Proline Dioxygenase;Proline;promoter;Proteins;Reader;recruit;Reporting;Repression;Role;Signal Transduction;Solid;Tail;triple-negative invasive breast carcinoma;tumorigenesis;ubiquitin-protein ligase;Ubiquitination;Western Blotting;WNT Signaling Pathway;Writing

PROJECT_TITLE: A New Histone H3 Modification Regulates Epigenetic Programming and Gene Expression in Breast Cancer


NIH_SPENDING_CATS: Brain Disorders;Cerebrovascular;Disability Research;Machine Learning and Artificial Intelligence;Neurosciences;Stroke

ORG_CITY: IRVINE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Stroke is one of the leading causes of death and the leading cause of long-term disability in the USA, and most of strokes originate from blood flow blockage known as ischemic stroke. This proposal seeks to elucidate how the spread of evoked activity in cortex predicts the location and volume of stroke protection and stroke damage in animal model of ischemic cortical stroke. We propose to apply a battery of the state-of-the- art multimodal techniques that will enable detailed quantitative studies of our hypothesis, which has clear translational potential.

PI_NAMEs: FROSTIG, RON D (contact)

PROJECT_TERMS: Acoustic Stimulation;Address;Adult;Anatomy;Anesthesia procedures;Animal Model;Architecture;artery occlusion;Auditory area;awake;Behavior assessment;Blood flow;Cause of Death;Complementary therapies;Cortical vasculature;Development;Dorsal;Early treatment;Electrophysiology (science);experimental study;Female;Functional Imaging;gray matter;Head;Histologic;histological studies;Histology;Hour;Human;Hybrids;Image;Imaging Techniques;in vivo;Infarction;Intervention Studies;Ischemia;Ischemic Stroke;Lateral;Lidocaine;Location;Long term disability;Machine Learning;machine learning algorithm;male;Maps;Microelectrodes;middle cerebral artery;Middle Cerebral Artery Occlusion;Modeling;multimodality;Neurons;neurovascular;novel;Outcome;Pharmacological Treatment;Play;Population;pre-clinical;programs;Rattus;Research;Rest;Role;Sensory;Series;Sodium Channel Blockers;spatiotemporal;Stroke;Stroke Volume;Structure;Tactile;tactile stimulation;Techniques;Testing;translational potential;Vibrissae;young adult

PROJECT_TITLE: The relationship between neuronal activity and stroke

STUDY_SECTION: BINP

STUDY_SECTION_NAME: Brain Injury and Neurovascular Pathologies Study Section[BINP]


ADMINISTERING_IC: DC

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Autism;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric;Prevention

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Children with autism often look less to audiovisual speech, a phenomenon that has been associated with language ability, and audiovisual speech processing may explain the association between looking to audiovisual speech and language ability. Identifying when differences in speech processing emerge in development, as well as their relation to early differences in looking to audiovisual speech and language understanding and use, is critical for better understanding how autism develops, potentially improving early diagnosis and intervention. This project will evaluate when a neural index of speech processing efficiency emerges in infancy as well as whether infants at increased likelihood for autism show differences in the level of speech processing efficiency in relation to looking to audiovisual speech and language understanding and use.

PI_NAMEs: DUNHAM-CARR, KACIE  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: Age;Age Months;Attention;audiovisual speech;Auditory;Autism Diagnosis;autism spectrum disorder;autistic children;Behavior assessment;Child;Communication impairment;Cueing for speech;Cues;Data;Development;Early Diagnosis;Early identification;Early Intervention;Electroencephalography;Event-Related Potentials;experience;Eye;Family;Fellowship;Future;gaze;General Population;Heterogeneity;improved;indexing;Individual;Individual Differences;individuals with autism spectrum disorder;infancy;Infant;Language;Language Delays;Language Development;Language Disorders;language impairment;Learning;Life;life span;Link;Measures;Mediating;Mediation;Modeling;Movement;multisensory;neural;neuromechanism;novel;Oral cavity;Outcome;Parents;peer;Population;preventive intervention;Proxy;Recording of previous events;Reporting;Research;Research Personnel;Research Priority;response;Risk;Role;Siblings;Signal Transduction;social;Speech;speech processing;Standardization;success;Testing;Visual;visual speech;visual tracking;Vocation;Work

PROJECT_TITLE: Looking to and Processing of Audiovisual Speech in Infants at Risk for Autism


PHR: Narrative Brain ischemia is a major cause of morbidity and mortality in which opening of the mitochondrial permeability transition pore (mPTP) contributes prominently to damage. We have described the molecular identity of the channel of mPTP recently and have made mutations in the structure that decrease channel opening and protect neurons from death. In this proposal, we will determine if the mutant channel prevents pathological effects in rodent models of brain ischemia.

PI_NAMEs: JONAS, ELIZABETH ANN (contact)

PROGRAM_OFFICER_NAME: HEWETT, SANDRA JEANNE

PROJECT_TERMS: Affect;Apoptotic;Attenuated;Basic Science;bcl-xlong protein;BCL2 gene;Behavior;Behavioral;Binding;Biological Assay;Brain;Brain Diseases;Brain Ischemia;Calcium;Caspase;Cell Death;Cessation of life;Chemicals;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Complex;cyclophilin D;Cyclosporine;Disease;Event;excitotoxicity;Family member;Funding;gene-editing approach;Genetic;genetic approach;Glutamates;Goals;Hippocampus;Hour;Human;in vitro Model;in vivo;inhibitor;Injury;Inner mitochondrial membrane;Intervention;Ion Channel;Ischemia;Ischemic Brain Injury;Knock-in;Korsakoff Syndrome;long term memory;Measures;Membrane;Membrane Potentials;Memory;Memory impairment;Memory Loss;Mitochondria;mitochondrial membrane;mitochondrial permeability transition pore;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;mutant;Mutant Strains Mice;Mutation;neuron loss;Neuronal Hypoxia;neuronal survival;Neurons;neuroprotection;Outer Mitochondrial Membrane;patch clamp;Patch-Clamp Techniques;Pathologic;Peptidylprolyl Isomerase;Permeability;pharmacologic;Phase;preservation;prevent;protective effect;Protein Family;Protein Isoforms;Protocols documentation;Reperfusion Therapy;Reporting;Resistance;Rodent;Rodent Model;Structure;Swelling;Synapses;Testing

PROJECT_TITLE: Mitochondrial Ion Channels in Hypoxic Neurons

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Neurosciences

ORG_CITY: INDIANAPOLIS

ORG_DEPT: PHARMACOLOGY

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: PROJECT NARRATIVE Toxoplasma gondii is an opportunistic parasite that develops into latent tissue cysts that largely form in the brain and give rise to life-threatening chronic toxoplasmosis. There is currently no approved treatment for the eradication of tissue cysts, but we have identified key translation initiation factors that coordinate changes in protein synthesis required for conversion to the latent cyst stage. The goal of this proposal is to determine how these translation initiation factors collaborate to overcome obstacles in regulatory regions of mRNA and permit transition to the latent stage of infection in neuronal cells, which promises to reveal important vulnerabilities that could be targeted by new drugs to combat toxoplasmosis.

PI_NAMEs: SULLIVAN, WILLIAM J (contact);WEK, RONALD C

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Acute;Address;Animals;Area;Automobile Driving;Binding;Brain;Cells;Chronic;Clinical;Collaborations;Collection;combat;Complex;Cyst;Data;Development;enhancer-binding protein AP-2;Eukaryotic Initiation Factor-2;Goals;helicase;Human;Immune;Immunosuppression;Individual;Infection;Initiator Codon;innovation;insight;Knowledge;Laboratories;Life;Messenger RNA;Modeling;mRNA capping;mRNA Translation;Myocardium;Neurologic;Neurons;new therapeutic target;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Open Reading Frames;Opportunistic Infections;Parasites;Patients;Peptide Initiation Factors;Pharmacotherapy;Phosphorylation;Phosphotransferases;Physiological;Population;prevent;programs;Proliferating;Protein Biosynthesis;Protein Synthesis Induction;recruit;Recurrence;Regulatory Element;response;ribosome profiling;Ribosomes;Risk;RNA;RNA Helicase;Role;Scanning;side effect;Signal Transduction;Skeletal Muscle;Stress;stress management;stress reduction;Structure;Symptoms;System;Therapeutic Intervention;Tissues;Toxoplasma;Toxoplasma gondii;Toxoplasmosis;transcription factor;Transfer RNA;Translating;Translation Initiation;Translations;translatome;Work

PROJECT_TITLE: Translation initiation factors driving persistence of Toxoplasma gondii bradyzoites in neurons


NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Eye Disease and Disorders of Vision;Neurosciences;Rehabilitation

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative The goal of this project is to determine how well the neural code of the primate central retina can be reproduced using electrical stimulation and recording of retinal ganglion cells (RGCs) in the central retina at cellular resolution, for the development of a future retinal prosthesis to treat blindness. Using high-density multi-electrode arrays, we obtain recordings during visual and electrical stimulation of several hundred RGCs of types that convey critical information about the visual world to the brain. This work will reveal the neural encoding properties of major RGC types in the central retina as well as what patterns of RGC activity can be reproduced with electrical stimulation, which together will afford an understanding of the expected vision restoration quality that can be provided with a future retinal implant.

PI_NAMEs: GOGLIETTINO, ALEX RICHARD (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Affect;Axon;Blindness;Brain;cell type;Cells;Code;Communication;Custom;Data;Data Set;density;Development;Devices;disability;electric field;Electric Stimulation;Electrodes;Excision;Exhibits;experimental study;Eye Movements;Frequencies;Future;Goals;Grain;Image;image reconstruction;Implant;improved;Individual;Inner Limiting Membrane;interest;Laboratories;Light;Macaca;Methods;Modeling;Modernization;Monkeys;multi-electrode arrays;neural;Pattern;Performance;performance tests;Peripheral;Photic Stimulation;photoreceptor degeneration;Primates;Property;Prosthesis;Prosthesis Design;prototype;Reaction Time;receptive field;reconstruction;Research;Resolution;response;Retina;retina implantation;Retinal Ganglion Cells;retinal prosthesis;retinal stimulation;sight restoration;Signal Transduction;simulation;spatiotemporal;Structure;Technology;Testing;Training;Vision;Visual;Visual Acuity;visual coding;Visually Impaired Persons;Work

PROJECT_TITLE: Probing visual computations and electrical stimulation in the central macaque retina for high fidelity vision restoration


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Orphan Drug;Radiation Oncology;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: PROJECT NARRATIVE The proposed research aims to improve patients' quality of life, harboring HPV oropharyngeal tumors, by administering specific targeted drugs to create genomic instability through reduced viral and DNA damage gene expression. Targeting these DNA repair-deficient tumors with a lowered radiation dose will eradicate the tumors.

PI_NAMEs: IYER, GOPAL  (contact)

PROGRAM_OFFICER_NAME: PRASANNA, PAT G

PROJECT_TERMS: Address;Apoptosis;biomarker selection;Blood;Bromodomain;Bromodomains and extra-terminal domain inhibitor;cancer cell;Cancer Etiology;Cell Cycle;Cell Line;Cells;Cessation of life;Characteristics;Chemicals;Cisplatin;Clinical Trials;comorbidity;Complete Blood Count;Country;Data;Deglutition Disorders;Dependence;design;Diagnosis;DNA;DNA Crosslinking;DNA Damage;DNA Double Strand Break;DNA Repair;DNA Repair Disorder;DNA Repair Gene;Dose;Double Strand Break Repair;Drug Targeting;efficacy testing;Enteral Feeding;established cell line;experimental study;Family;Gene Expression;gene repression;Generations;Genes;Genetic Transcription;Genomic Instability;Genomics;Goals;Growth;HPV oropharyngeal cancer;human papilloma virus oropharyngeal squamous cell carcinoma;Human Papillomavirus;Immunohistochemistry;improved;In Vitro;in vivo;Incidence;Individual;inhibitor;Kinetics;knock-down;Lead;Length;Low Dose Radiation;Malignant Epithelial Cell;Malignant neoplasm of cervix uteri;malignant oropharynx neoplasm;Measurement;Measures;member;men;Modification;Molecular;mouse model;neoplastic cell;new therapeutic target;Oropharyngeal;Oropharyngeal Neoplasms;Oropharyngeal Squamous Cell Carcinoma;Output;Pathway interactions;patient derived xenograft model;Patient Selection;Patients;Pattern;pleiotropism;Population;preservation;programs;Proliferating;Proteins;Quality of life;Radiation;Radiation Dose Unit;Radiation therapy;recruit;Research;response;RNA;secondary endpoint;Series;Specificity;standard of care;Subgroup;Surrogate Markers;Survival Analysis;Survival Rate;targeted treatment;Testing;Therapeutic;Tissues;Toxic effect;Transcriptional Regulation;transcriptome sequencing;Treatment Protocols;treatment strategy;Treatment-related toxicity;tumor;Tumor Cell Line;tumor eradication;tumor growth;tumor progression;Tumor Volume;tumor xenograft;United States;USP6 gene;Viral;viral DNA;Viral Genes;Viral Genome;Viral Markers;Virus Integration;Woman

PROJECT_TITLE: Combining BET protein inhibitors with radiation in HPV oropharyngeal cancer


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Hepatitis;Liver Disease;Nutrition;Obesity

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

PHR: PROJECT NARRATIVE In predisposed individuals, obesity is associated with the accumulation of fat in the liver, a process termed non- alcoholic fatty liver disease (NAFLD), which itself is a predictor of subsequent liver inflammation, scarring, and in some, ultimately liver failure or cancer. In probing ways to mitigate NAFLD and its harmful consequences, which are rising at an alarming rate in the U.S., we have built on intriguing findings from our lab showing that a protein, IRE1alpha (IRE1a), in a specific class of immune cells called myeloid cells (MCs), mediates activation of a powerful inflammatory apparatus, called the NLRP3 inflammasome, in response to high levels of saturated fats which are often elevated in the livers of people with NAFLD. Here, using cutting-edge genetic tools to manipulate IRE1a specifically in MCs both in culture and in living mice, we aim to A) test the extent to which MC- specific IRE1a can be targeted to prevent and potentially reverse NAFLD and its consequences, and B) identify the specific region of IRE1a that saturated fats interact with in order to activate the NLRP3 inflammasome, which is an active clinical target for treatment of obesity-associated metabolic diseases.

PI_NAMEs: BOLUS, WILLIAM REID (contact)

PROGRAM_OFFICER_NAME: DENSMORE, CHRISTINE L

PROJECT_TERMS: Affect;American;Apoptosis;Biomedical Research;Bolus Infusion;Caliber;Cells;Cholesterol;Chronic;Cicatrix;Clinical;comorbidity;Coupled;Cre-LoxP;cytokine;Data;design;Development;Diet;dietary;dietary excess;Disease;Elemental Diets;Elements;Endoplasmic Reticulum;endoplasmic reticulum stress;Endoribonucleases;Engineering;Environment;Enzymes;experience;Fatty acid glycerol esters;Fatty Liver;Fibrosis;Fostering;Fructose;Funding;Genetic;Goals;Grant;Health;Healthcare;Hepatic;Human;Immune;immunoregulation;improved;Incidence;Individual;Infiltration;Inflammasome;Inflammatory;innovation;Inositol;Institution;Insulin Resistance;Knowledge;Kupffer Cells;Letters;Liver;Liver Cirrhosis;Liver diseases;Liver Failure;Liver Fibrosis;liver function;liver inflammation;liver transplantation;Macrophage;Malignant neoplasm of liver;Measures;Mediating;Mediator;Membrane;Mentorship;Metabolic Diseases;Metabolic dysfunction;Modernization;Molecular;monocyte;mouse model;Mus;Myelogenous;Myeloid Cells;non-alcoholic fatty liver disease;Non-Insulin-Dependent Diabetes Mellitus;nonalcoholic steatohepatitis;Nutrient;Obesity;obesity treatment;Pathogenesis;Pathology;Persons;Pharmaceutical Preparations;Phospholipids;Population;prevent;Primary carcinoma of the liver cells;Process;Production;Proteins;Publishing;Reagent;recruit;Research;Research Personnel;Research Project Grants;response;Ribonucleases;Risk;RNA Splicing;Role;saturated fat;Saturated Fatty Acids;sensor;Severity of illness;Signal Transduction;skills;sugar;Testing;Therapeutic;Tissues;tool;Training;Type 2 diabetic;United States National Institutes of Health;verbal;Visual;western diet;Work;Writing;XBP1 gene

PROJECT_TITLE: Myeloid-specific IRE1alpha as a mediator of nonalcoholic fatty liver disease


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Neurosciences;Physical Injury - Accidents and Adverse Effects;Physical Rehabilitation;Rehabilitation;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: CHARLESTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: MEDICAL UNIVERSITY OF SOUTH CAROLINA

ORG_STATE: SC

PHR: Project Narrative Developing new neurorehabilitation approaches is critically important for maximizing function recovery and re- establishing an active, productive, fulfilling life in people after SCI. Through this project, we seek to characterize the physiological mechanisms and effects of MEP operant conditioning, and thereby its value as a neuromodulation tool for rehabilitation. Successful completion of this project will accelerate development and clinical translation of MEP operant conditioning, as a novel non-invasive therapy that may complement other therapies and further enhance recovery in people with SCI or other disorders.

PI_NAMEs: THOMPSON, AIKO  (contact)

PROJECT_TERMS: Acceleration;Ankle;ankle joint;ankle joint dorsiflexor;Bilateral;Chronic;clinical translation;common treatment;Compensation;Complement;conditioning;cortex mapping;Cutaneous;Data;Development;Disease;equilibrium model;Exposure to;foot;Foot-drop;Gait;Gait abnormality;H-Reflex;Hip region structure;Impairment;improved;improved outcome;Individual;Injury;Intervention;Joints;kinematics;Knee;Leg;Life;Location;Locomotion;Maps;Measurement;Measures;Mediation;Motion;motor control;Motor Cortex;Motor Evoked Potentials;motor function improvement;motor impairment;motor recovery;Muscle;Nature;neurological rehabilitation;neuromechanism;Neuronal Plasticity;neuroregulation;novel;Operant Conditioning;Orthotic Devices;Participant;Pathway interactions;Persons;Phase;Physical therapy;Physiological;Population;Process;Productivity;Protocols documentation;Recovery;Recovery of Function;recruit;Reflex action;Rehabilitation therapy;response;Shapes;Site;Spinal cord injury;spinal reflex;standard care;Stimulus;Testing;tibialis anterior muscle;Time;tool;Transcranial magnetic stimulation;Walking

PROJECT_TITLE: Characterization of Physiological Changes Induced Through MEP Conditioning in People with SCI

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Aphasia;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Dementia;Frontotemporal Dementia (FTD);Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Rare Diseases;Social Determinants of Health

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: PROJECT NARRATIVE Close interpersonal connectedness to others, particularly loved ones, is critical for health and well-being. The proposed project will examine how interpersonal connectedness between patients and spousal caregivers changes in frontotemporal dementia, and how these changes in connectedness form a bridge that links a patient’s disruptive symptoms to problems in a caregiver’s health. Patient-caregiver connectedness will be studied using a novel, objective, and less cognitively-demanding approach by measuring how closely their behavior and physiological responses are “linked” during dyadic interactions.

PI_NAMEs: CHEN, KUAN-HUA  (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: actigraphy;Adverse effects;Affect;Aging;Alzheimer's Disease;Aphasia;Area;Award;Behavior;Behavioral;Behavioral Symptoms;behavioral variant frontotemporal dementia;Brain;Brain region;California;Cardiovascular system;career;Caregiver Burden;caregiver depression;Caregivers;caregiving;Caring;cingulate cortex;Clinical;Clinical assessments;Cognitive;cognitive function;cognitive neuroscience;Coupled;Data;Data Analyses;Dementia;Dementia caregivers;dementia caregiving;Diagnosis;Disease;Disinhibition;dyadic interaction;Economic Burden;Emotional;emotional behavior;emotional functioning;emotional symptom;Emotions;Environment;experience;Face;Family;family support;Financial Hardship;Frontotemporal Dementia;Galvanic Skin Response;Health;Heart Rate;Home;Humor;Impaired cognition;Impairment;Individual;Insula of Reil;Knowledge;Laboratories;Life;Link;loved ones;Measures;Mediating;Memory;Mental Depression;Mental Health;Mentorship;Methodology;Methods;Modeling;Monitor;mortality;Nature;Nerve Degeneration;neural;Neurobehavioral Manifestations;Neurodegenerative Disorders;Neurologist;novel;novel strategies;Nurses;Pathway interactions;Patient Self-Report;Patients;Pattern;Personal Satisfaction;Persons;physical conditioning;Physiological;Play;Population;portability;Progressive Nonfluent Aphasias;Psychologist;Psychology;Psychophysiology;Reporting;Research;response;Role;San Francisco;Scientist;Semantics;sensor;Series;skills;social;Social Functioning;Social support;socioeconomics;Solid;Specialist;Specificity;Spouse Caregiver;Stress;Symptoms;Testing;Time;Training;Universities;Variant;Wrist

PROJECT_TITLE: Behavioral and physiological linkage in people with frontotemporal dementia and spousal caregivers

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Behavior and Social Science of Aging Study Section[NIA-S]


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Glaucoma is the second leading cause of blindness worldwide, with elevated pressure in the eye as its primary risk factor; indeed, all current treatments try to lower eye pressure, but are at times unsuccessful. The conventional outflow pathway is the part of the eye that regulates eye pressure, and this pathway houses many resident immune cells, but their function is not well understood. This project is designed to interrogate immune cell function in eye pressure control, results of which will shape future therapeutic strategies for glaucoma.

PI_NAMEs: LIU, KATY C (contact)

PROJECT_TERMS: Ablation;Adrenal Cortex Hormones;Anterior;aqueous;Biological Assay;Biological Response Modifiers;Biomechanics;Biometry;blind;Blindness;Blood;Blood Vessels;Bone Marrow;career;career development;CD44 Antigens;Cell Physiology;Cells;Collagen;confocal imaging;Data;design;Development Plans;Distal;Doctor of Philosophy;Educational workshop;Eligibility Determination;Endothelium;Environment;experience;experimental study;Extracellular Matrix;Eye;eye center;Faculty;Fellowship;Flow Cytometry;Foundations;Funding;Future;Generations;Genes;Genetic;Genetic Transcription;Glaucoma;Glucocorticoids;Goals;Grant;Homeostasis;Human;Immune;Immune response;Immune system;Immunologic Factors;Immunology;Immunomodulators;improved;Individual;Institution;Knowledge;Label;Lasers;LoxP-flanked allele;lymphatic vessel;Macrophage;Measures;Mediating;meetings;Mentors;Mentorship;modifiable risk;Molecular;Monitor;mouse genetics;mouse model;Mus;novel;Nursing Faculty;Ophthalmologist;Pathway interactions;Patients;Phagocytes;pharmacologic;Phenotype;Physiologic Intraocular Pressure;Physiology;Population;postnatal;prenatal;pressure;programs;Prostaglandins;Publications;Regulation;repaired;Research;research faculty;Resistance;responsible research conduct;Risk Factors;Role;Scientist;Shapes;single-cell RNA sequencing;skills;Smooth Muscle;Structure of sinus venosus of sclera;Synthetic Prostaglandins;Teacher Professional Development;Testing;Therapeutic;therapeutic target;Tissues;tool;Trabecular meshwork structure;Training;transcriptome;Transforming Growth Factor beta;Transforming Growth Factor Beta 2;treatment and outcome;Vascularization;Veins;Work

PROJECT_TITLE: Role of Tissue Resident Macrophages in Conventional Outflow Function


NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

PHR: PROJECT NARRATIVE. Identification of genetic risk factors associated with Age-Related Macular Degeneration (AMD) has thus far outpaced the investigations into the biological consequences of the identified genetic variants. This project aims to take an unbiased approach to survey the interactions of over 100 genetic variants associated with AMD with the human transcription factor proteome, which may lead to novel mechanistic insight and provide a new platform to study genetic risk.

PI_NAMEs: QIAN, JIANG ;ZACK, DONALD J. (contact)

PROGRAM_OFFICER_NAME: SHEN, GRACE L

PROJECT_TERMS: Affect;Affinity;age related;Age related macular degeneration;Alleles;American;ATAC-seq;Atrophic;Base Pairing;bevacizumab;Binding;Binding Proteins;Binding Sites;Biochemical;Bioinformatics;Biological;Biological Assay;Blindness;cell behavior;Cell Differentiation process;Cell Physiology;cell type;Cells;Chromatin;chromatin immunoprecipitation;Clustered Regularly Interspaced Short Palindromic Repeats;Code;complement system;CRISPR interference;Data;Development;Disease;disorder risk;DNA;DNA Binding;DNA Probes;DNA-Binding Proteins;DNA-Protein Interaction;Dryness;effective therapy;Effectiveness;Elderly;Electrophoretic Mobility Shift Assay;Engineering;ES Cell Line;Functional disorder;Gene Expression;Genetic Predisposition to Disease;Genetic Risk;genetic risk factor;Genetic study;Genetic Transcription;genetic variant;Genome;genome editing;genome wide association study;genomic locus;Goals;Heterozygote;high risk;high throughput screening;Human;human embryonic stem cell;human stem cell-derived;human stem cells;Immunoprecipitation;In Vitro;Individual;insight;interest;Interferometry;Investigation;Knowledge;Lead;Length;loss of function;Luciferases;Maps;Molecular;neovascular;Neurodegenerative Disorders;novel;novel therapeutics;Phenotype;Photoreceptors;Population;Predisposition;Protein Analysis;Protein Array;Protein Microchips;Proteins;Proteome;Public Health;Quantitative Trait Loci;Reporter;Research;Resources;response;Retina;Risk;risk variant;RNA-Binding Proteins;Role;screening;Series;Single Nucleotide Polymorphism;Site;Specificity;Stress;stressor;Structure of retinal pigment epithelium;success;Surveys;Technology;Testing;transcription factor;Transcriptional Regulation;Transposase;treatment strategy;Untranslated RNA;Validation;XCL1 gene

PROJECT_TITLE: Connecting AMD SNPs to Functions Using Allele-specific Interactions

STUDY_SECTION: DPVS

STUDY_SECTION_NAME: Diseases and Pathophysiology of the Visual System Study Section[DPVS]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: BIRMINGHAM

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative The project will establish a novel generation of personalized cardiac patch devices for remuscularization of heart with postinfarction LV remodeling, which is one of the most significant problem in public health. The central hypothesis is that the novel bioengineered and perfusable cardiac patch using novel hiPSC lines, can remuscularize the ischemic injured heart using minimally invasive technologies. The findings will have significant impact in diagnostic and treatment of heart failure, and improve the public health.

PI_NAMEs: SERPOOSHAN, VAHID ;ZHANG, JIANYI  (contact)

PROGRAM_OFFICER_NAME: LUNDBERG, MARTHA

PROJECT_TERMS: 3-Dimensional;3D Print;Achievement;Acute;Acute myocardial infarction;Adult;Angiogenic Factor;animal data;Apoptotic;Arrhythmia;bioink;Biomechanics;Biomedical Engineering;bioprinting;Bioreactors;Birth;Blood Vessels;BMP4;Cardiac;Cardiac Myocytes;cardioprotection;Catheters;CCND2 gene;cdc Genes;Cell Cycle;Cell Line;Cell Proliferation;Cell Surface Receptors;cell type;Cells;Characteristics;Chemicals;Chest;Chronic;Cicatrix;Clinical;clinical application;clinically relevant;comparative efficacy;Congestive Heart Failure;Coupling;Cues;Death Rate;design;Devices;Diagnostic;Dilatation - action;Echocardiography;effectiveness evaluation;Electric Stimulation;Encapsulated;Endothelial Cells;endothelial stem cell;Engineering;Engraftment;Epicardium;Face;Family suidae;Fibroblasts;Follistatin;Follistatin-Related Protein 1;Gadolinium;Gelatin;Generations;Geometry;Glycoproteins;glycosylation;Heart;Heart failure;heart function;Heart Injuries;Human Cell Line;human induced pluripotent stem cells;Hydrogels;implantation;improved;In Vitro;induced pluripotent stem cell derived cardiomyocytes;Infarction;Infusion procedures;Injections;Ischemia;ischemic cardiomyopathy;ischemic injury;knock-down;Label;Left;Left Ventricular Dysfunction;Left Ventricular Remodeling;Left ventricular structure;Magnetic Resonance Imaging;Maps;Mediating;meter;Methacrylates;Methods;minimally invasive;Molecular;mouse model;Mus;Muscle;Muscle Cells;Myocardial;Myocardial Infarction;Myocardial Ischemia;Myocardium;novel;Optics;overexpression;Patients;Perfusion;Pericardial body location;Periodicity;Pilot Projects;Population;porcine model;pre-clinical assessment;prevent;Printing;Process;Proliferating;promoter;Proto-Oncogene Proteins c-akt;Public Health;receptor;regeneration function;repaired;Reperfusion Therapy;Reporting;Resolution;response;Risk;Risk Reduction;Role;scaffold;Shapes;Signal Pathway;Signal Transduction;Small Interfering RNA;Smooth Muscle Myocytes;Stretching;Surface;Technology;Testing;Therapeutic;Time;Tissue Model;Tissues;Transplantation;Treatment Protocols;Vascularization;Ventricular

PROJECT_TITLE: Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytes

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-TDPS-R(01)]


NIH_SPENDING_CATS: Aging;Eye Disease and Disorders of Vision;Genetics;Lymphatic Research;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: Project narrative High intraocular pressure is a key risk factor for glaucoma. This application will define and critically test key molecular events that control intraocular pressure and that act to lessen its magnitude by increasing ocular fluid drainage or outflow. Understanding these molecular processes will ultimately lead to a rational design of new treatment strategies to prevent glaucoma.

PI_NAMEs: JOHN, SIMON W (contact);KIZHATIL, KRISHNAKUMAR

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: Address;Adherens Junction;Affect;Antibodies;Apical;Aqueous Humor;aqueous humor flow;Biochemical;Biological Models;Biology;Biomechanics;Blood Vessels;cadherin 5;Clustered Regularly Interspaced Short Palindromic Repeats;Complex;confocal imaging;Cytoplasmic Tail;Data;Drainage procedure;Electron Microscopy;Endothelial Cells;Endothelium;Event;Exposure to;Genes;Genetic;Glaucoma;Goals;high intraocular pressure;Human;Immunofluorescence Immunologic;improved;in vivo;Individual;innovation;Intercellular Junctions;Knock-in Mouse;Knock-out;knockout gene;Knowledge;Label;Lentivirus;light microscopy;Liquid substance;LoxP-flanked allele;Lymphatic Endothelial Cells;Measures;mechanical force;mechanotransduction;Mediating;Modeling;Molecular;Molecular Profiling;Mus;mutant;Mutant Strains Mice;Mutate;new technology;novel;novel therapeutic intervention;Pathology;Pathway interactions;PECAM1 gene;Permeability;Pharmaceutical Preparations;Phenylalanine;Phosphoproteins;Phosphorylation;Physiologic Intraocular Pressure;Positioning Attribute;pressure;prevent;Primary Open Angle Glaucoma;Process;Property;protein complex;Proteins;rational design;Regulation;Resistance;Resolution;response;Risk;Risk Factors;Role;sensor;shear stress;Signal Transduction;Signaling Molecule;Site;Structure of sinus venosus of sclera;Study models;Testing;tool;Tracer;Translating;Tyrosine;Tyrosine Phosphorylation

PROJECT_TITLE: Does VECAD at Schlemm canal cell-junctions determine IOP and glaucoma risk?


NIH_SPENDING_CATS: Infectious Diseases;Lung;Microbiome;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pneumonia;Pneumonia and Influenza;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE: Pneumonia kills more than one million infants around the world each year. A group of white blood cells, known as lymphoid cells, are necessary for the protection of newborn infants against pneumonia. Clinical interventions in premature infants, such as the use of antibiotics alter microbiota and decrease the numbers of protective lymphoid cells in the infant's lungs. Similarly, therapies such as mechanical ventilation and corticosteroids interrupt the development of infant's lungs and decrease the numbers of protective lymphoid cells. Therefore, understanding how signals from microbiota and infant's lungs increase the number of protective lymphoid cells is important.

PI_NAMEs: DESHMUKH, HITESH  (contact)

PROGRAM_OFFICER_NAME: SOOD, BEENA G

PROJECT_TERMS: Ablation;Adolescence;Adrenal Cortex Hormones;Affect;Alveolus;Antibiotics;Bacterial Pneumonia;Biological Assay;Bronchopulmonary Dysplasia;Cell Differentiation process;Cell Reprogramming;Cells;Cellular Metabolic Process;Childhood;Chromatin;Clinical;commensal bacteria;commensal microbes;Complex;Cues;cytokine;Development;directed differentiation;Endowment;Ensure;Environment;EZH2 gene;fetal;fitness;FRAP1 gene;Genes;Genetic Transcription;Glycolysis;Growth;gut microbiota;Homeostasis;IGF1 gene;Immune;immune function;infancy;Infant;Infant Development;Insulin-Like Growth Factor I;interleukin-22;Interruption;Intervention;Knowledge;Leukocytes;Life;Long-Term Effects;Lung;Lymphocyte;Lymphoid Cell;Lymphoid Tissue;Maintenance;Mechanical ventilation;Mesenchymal;Metabolic;metabolic profile;Metabolism;Methyltransferase;microbiota;Modeling;Morbidity - disease rate;Mucous Membrane;Mus;Neonatal lung;Newborn Infant;Pattern;perinatal environment;perinatal period;Physiology;Pneumonia;postnatal;Predisposition;Premature Infant;Production;programs;Proliferating;Publishing;pulmonary function;Residencies;respiratory pathogen;Respiratory Tract Infections;Risk;secondary lymphoid organ;Signal Transduction;stem cells;Stromal Cells;Testing;Tissues

PROJECT_TITLE: Tissue niches for ILC3 development in newborn's lung

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Cancer;Emerging Infectious Diseases;HIV/AIDS;Infectious Diseases;Rare Diseases

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

PHR: PROJECT NARRATIVE During replication, the AIDS-associated tumor virus Kaposi’s sarcoma-associated herpesvirus (KSHV) strongly blocks cellular responses to replicate efficiently. Since replication is needed for development and maintenance of Kaposi’s sarcoma and other KSHV-induced tumors, KSHV immune evasion could be exploited to treat these diseases. In this project, we will investigate the role of a cellular enzyme, caspase-8, in KSHV inhibition of cellular response to understand immune evasion by this virus and potentially identify new druggable targets against KSHV infection.

PI_NAMEs: GAGLIA, MARTA MARIA (contact)

PROGRAM_OFFICER_NAME: READ-CONNOLE, ELIZABETH LEE

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Affect;Africa South of the Sahara;AIDS related cancer;Anti-viral Response;Apoptosis;Apoptotic;Autoimmune Diseases;Biology;cancer type;CASP8 gene;Caspase;Cell Death;Cells;Cessation of life;Communicable Diseases;Complex;Cytoplasm;Data;Development;Disease;DNA;druggable target;Enzymes;experience;Genetic Transcription;Herpesviridae;Herpesviridae Infections;Human Herpesvirus 8;Immune Evasion;Immune response;Infection;inhibitor;Innate Immune Response;insight;Interferon Type I;Interferons;Kaposi Sarcoma;Lytic Phase;Maintenance;Mediating;Mediator;Molecular;mutant;Nature;new therapeutic target;Oncogenic Viruses;overexpression;pathogen;Pathway interactions;Peptide Hydrolases;prevent;Production;Proteins;reactivation from latency;receptor;Receptor Signaling;Regulation;Regulatory Pathway;Reporting;response;Role;Signal Transduction;Stimulus;targeted treatment;Testing;TLR3 gene;Toll-Like Receptor Pathway;Toll-like receptors;tumor;Tumor Immunity;Up-Regulation;Viral;Virus;virus host interaction;Virus Replication;Work

PROJECT_TITLE: Determining how Kaposi’s sarcoma-associated herpesvirus hijacks caspase function to inhibit anti-viral responses

STUDY_SECTION: HCAC

STUDY_SECTION_NAME: HIV Coinfections and HIV Associated Cancers Study Section[HCAC]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Neurosciences;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: LOS ANGELES

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: Project Narrative The mammalian retina is a highly organized structure, made of more than 60 types of neuron and glia, that together detect light, extract useful visual features, and pass those to the brain. The efforts to regenerate retinal cells, when they are affected by disorders that lead to blindness, have been hampered by lack of knowledge about how they are normally made during development. To address this problem, here I propose to combine my training in synthetic and developmental biology to develop novel technologies that provide an unprecedented view of retinal development.

PI_NAMEs: ASKARY, AMJAD  (contact)

PROGRAM_OFFICER_NAME: WRIGHT, CHARLES BAKER

PROJECT_TERMS: Address;Affect;Area;Award;Bar Codes;base editor;Biology;Biomedical Engineering;Birth;Blindness;Brain;career;cell fate specification;Cell Lineage;cell type;Cells;cellular development;Chromatin;Clustered Regularly Interspaced Short Palindromic Repeats;Collaborations;Competence;Core Facility;design;Development;Developmental Biology;Disease;Engineering;Epigenetic Process;epigenetic regulation;experimental study;Future;Gene Expression Profile;Gene Expression Profiling;Generations;Genome;genome editing;Goals;graduate student;Grant;Heterogeneity;Image;In Situ;in situ imaging;Individual;Inherited;insight;International;Intrinsic factor;Knowledge;Label;Lead;Lentivirus Vector;Libraries;Light;Maps;Measurement;meetings;member;Mentors;Mentorship;Methods;Molecular;Mus;Mutation;neurogenesis;Neuroglia;Neurons;new technology;novel;Organism;organizational structure;Pathway interactions;Pattern;Pilot Projects;preservation;Process;progenitor;programs;Readability;reconstruction;Recording of previous events;Regenerative Medicine;Regulation;Research;Resources;Retina;Retinal Degeneration;retinal neuron;retinal progenitor cell;retinal regeneration;Role;Running;Signal Transduction;single cell genomics;Site;skills;Stereotyping;Structure;Students;success;synthetic biology;System;Technology;Time;Tissues;Training;Training Programs;Trees;Viral;Viral Genome;Vision;Visual;visual information;visual processing;Work;Writing

PROJECT_TITLE: Synthetic recording and in situ readout of cell lineage and molecular history in mammalian retina

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Childhood Leukemia;Clinical Research;Genetics;Hematology;Human Genome;Immunotherapy;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

PHR: PROJECT NARRATIVE Therapy for relapsed or refractory acute myelogenous leukemia (AML) remains suboptimal, and a phase I clinical trial using the first-in-human hepatocyte growth factor (HGF) antibody ficlatuzumab with cytarabine has demonstrated promising safety and efficacy. The proposed project combines prospectively-collected clinical specimens, vertebrate models, and an innovative spatial profiling platform to identify biomarkers of response and mechanisms of resistance. Findings from this study will 1) improve predictive biomarkers for patient stratification in future clinical trials, 2) enhance understanding of the biology underlying ficlatuzumab resistance, and 3) devise rationale combinations to augment the efficacy of ficlatuzumab.

PI_NAMEs: BLASER, BRADLEY WAYNE;WANG, VICTORIA  (contact)

PROGRAM_OFFICER_NAME: HU, ZHANG-ZHI

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute leukemia;Acute Myelocytic Leukemia;acute myeloid leukemia cell;Adult;Animals;Anthracycline;Antibodies;antitumor effect;Area;attenuation;autocrine;BCL1 Oncogene;BCL6 gene;Bioinformatics;Biology;biomarker discovery;biomarker identification;Blood;Bone Marrow;cancer cell;Cell Line;chemotherapy;Chromatin;Clinical;clinical development;Clinical stratification;Clinical Trials;Combined Modality Therapy;Complex;crizotinib;Cytarabine;cytokine;Cytometry;Cytotoxic Chemotherapy;Data;Development;Disease;Dose;Down-Regulation;Drops;Drug resistance;Eligibility Determination;Epigenetic Process;experience;EZH2 gene;first-in-human;Future;Gene Expression Profiling;Genetic;genetic corepressor;Genetic Models;Genetically Engineered Mouse;Growth Factor Inhibition;Hematopoiesis;HGF gene;high dimensionality;High Dose Chemotherapy;high throughput screening;human old age (65+);Immune;immune cell infiltrate;Immunotherapy;improved;In Vitro;in vivo;Inflammatory;inhibitor;innovation;Interferon Type I;Interferons;Intervention;leukemia;leukemogenesis;Link;loss of function mutation;Mediating;member;Modality;Modeling;Molecular;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;Mutation;Myelogenous;novel;novel therapeutics;Outcome;paracrine;Pathway interactions;Patient Selection;patient stratification;Patients;Peripheral Blood Mononuclear Cell;Phase;Phase I Clinical Trials;Phase Ib Clinical Trial;Polycomb;pre-clinical;Pre-Clinical Model;predicting response;predictive marker;Principal Investigator;Production;Prognosis;prognostic indicator;programmed cell death ligand 1;Proliferating;prospective;Proteins;Publishing;Quality of life;Recurrent disease;Refractory;Refractory Disease;Regimen;Regulation;Relapse;Reporting;Research;Resistance;resistance mechanism;response;response biomarker;Safety;Sampling;single cell analysis;single-cell RNA sequencing;Specimen;standard of care;Survival Rate;System;targeted agent;Technology;Testing;Therapeutic;therapeutic evaluation;Tissue-Specific Gene Expression;Toxic effect;Treatment Efficacy;tumor;tumor microenvironment;Tumor-associated macrophages;tumor-immune system interactions;United States;Up-Regulation;Vertebral column;Work;Zebrafish

PROJECT_TITLE: Targeting Autocrine Hepatocyte Growth Factor (HGF) Production as a Therapeutic Modality in Acute Myeloid Leukemia (AML)


NIH_SPENDING_CATS: Genetics;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Understanding how neurons are correctly assembled into functional circuits will provide critical insight into developmental disorders of the nervous system and may inform strategies to promote neuronal repair in cases of injury or disease. The current knowledge of the molecular genetic pathways that control neuronal development is incomplete. Our research program addresses three major questions related to the assembly of neural circuits: 1) How do transcription factors that control neuronal subtype identity coordinate the expression of axon guidance molecules that control wiring specificity? 2) What are the signaling mechanisms that allow conserved families of guidance receptors to control direction-selective axon growth and targeting? 3) How do navigating axons coordinate their responses to the diverse array of cues present during development to ensure assembly of functional circuits? Disruption of the function of many axon guidance molecules has been implicated in a number of human neuronal developmental disorders, as well as in various kinds of cancer. Thus, understanding the signaling mechanisms of these molecules in the context of normal development will be instrumental in understanding how their perturbation leads to pathogenesis.

PI_NAMEs: BASHAW, GREG J. (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Address;Area;Axon;axon growth;axon guidance;Biochemical;Biological;Cell Nucleus;Cells;Collaborations;Cues;Dendrites;Development;developmental disease;Disease;Drosophila genus;Embryonic Nervous System;Ensure;Family;Fluorescence-Activated Cell Sorting;Fos-Related Antigens;Genetic;genetic manipulation;Genetic Transcription;Human;in vitro activity;in vivo;Injury;insight;Knowledge;Link;Malignant Neoplasms;Methods;Modeling;Molecular;Molecular Biology;Molecular Genetics;Morphogenesis;Motor Neurons;mutant;Nerve Regeneration;Nervous System;nervous system development;Nervous System Disorder;neural;neural circuit;neuron development;Neurons;Output;Pathogenesis;Pathway interactions;Play;premature;programs;Property;Proteins;receptor;Receptor Activation;Receptor Signaling;Regulation;repaired;Reporter;Research;Resolution;response;Role;screening;Signal Pathway;Signal Transduction;Signaling Molecule;Specific qualifier value;Specificity;System;Testing;Therapeutic;Transcript;Transcription Coactivator;transcription factor

PROJECT_TITLE: Molecular mechanisms of axon guidance receptor regulation and signaling


NIH_SPENDING_CATS: Cardiovascular;Congenital Heart Disease;Congenital Structural Anomalies;Heart Disease;Nutrition;Pediatric;Prevention;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: EAST LANSING

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: MICHIGAN STATE UNIVERSITY

ORG_STATE: MI

PHR: Project narrative Congenital heart disease (CHD) is the most common birth defect, however its causes remain poorly understood. This project investigates the role of uncharacterized bioactive lipids, oxylipins, in human and mouse cardiac development and their connection with CHD, with the aim of providing new preventive and therapeutic options.

PI_NAMEs: AGUIRRE, AITOR  (contact)

PROGRAM_OFFICER_NAME: SCHRAMM, CHARLENE A

PROJECT_TERMS: 3-Dimensional;Address;Biochemical;Biological;Biology;Cardiac;cardiogenesis;Cardiovascular system;Cellular biology;Chemicals;Complex;Congenital Abnormality;congenital heart abnormality;Congenital Heart Defects;Data;Development;Diet;dietary;Dietary Factors;Dietary Fats;dietary restriction;druggable target;Early Diagnosis;Early treatment;Embryo;Extracellular Matrix;Functional disorder;Gene Expression;Genetic;Genetic Models;Heart;Human;Human Biology;Human body;human pluripotent stem cell;human stem cell-derived;human stem cells;in vivo;inhibitor;innovation;insight;Knock-out;Knockout Mice;Knowledge;Link;lipidomics;Lipids;Lipoxygenase;Malnutrition;Mesoderm;Methods;Modeling;Molecular;Molecular Biology;Morphogenesis;mouse model;Mus;novel;novel strategies;novel therapeutics;nutrition;Organoids;Play;Polyunsaturated Fatty Acids;prevent;Prevention;Prevention strategy;Preventive;Production;programs;receptor;Role;Signal Pathway;Signal Transduction;Signaling Molecule;Specific qualifier value;stem cell differentiation;stem cell model;Supplementation;Testing;Therapeutic;Time;Tissues;tool;transcription factor;WNT Signaling Pathway;Work

PROJECT_TITLE: Oxylipin Signaling in Congenital Heart Disease

STUDY_SECTION: CDD

STUDY_SECTION_NAME: Cardiovascular Differentiation and Development Study Section[CDD]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: CHICAGO

ORG_DEPT: PSYCHIATRY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE The goal of the proposed project is to identify the impact of psychomotor retardation on reward-based reinforcement learning in MDD using laboratory assessments of psychomotor functioning, a psychomotor manipulation during reinforcement learning, computational modeling, and neuroimaging. This comprehensive, multimethod research project will help to clarify the critical role of psychomotor retardation on the course of MDD and identify specific mechanisms of MDD that could be targeted in future studies of depression.

PI_NAMEs: LETKIEWICZ, ALLISON  (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Adult;Age;anti-depressive agents;Applications Grants;Award;Basal Ganglia;Behavior;behavior prediction;Behavioral;Blood flow;career;Clinical;clinically relevant;clinically significant;Cognitive;cognitive process;Computer Models;Corpus striatum structure;cost;Data;depressive symptoms;Diagnostics Research;Disease;Disease remission;Dorsal;Exhibits;experience;Functional Magnetic Resonance Imaging;Future;Goals;Grain;Grant;Impairment;Individual;innovation;Interview;K-Series Research Career Programs;Knowledge;Laboratories;Learning;Learning Difficulty;Life;Major Depressive Disorder;Measures;Mental Depression;Mental disorders;Mentors;Mentorship;Methods;Motor;neural;neural circuit;neural correlate;Neurobiology;neuroimaging;Outcome;Parameter Estimation;Parkinson Disease;Play;prevent;Principal Investigator;Process;prospective;Psychological reinforcement;Psychomotor Performance;Psychopathology;Recurrence;Reporting;Research;Research Domain Criteria;Research Methodology;Research Personnel;Research Project Grants;response;Rest;Rewards;Role;Schizophrenia;Scientist;skills;social;Speed;Symptoms;System;Task Performances;Testing;Training;Training Activity;treatment response;United States National Institutes of Health;Universities;Ventral Striatum

PROJECT_TITLE: Clarifying the Role of Psychomotor Retardation in Reward-Based Reinforcement Learning Deficits in MDD: A Computational and fMRI Study


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Eye Disease and Disorders of Vision;Neurosciences

ORG_CITY: LA JOLLA

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Project Narrative Whether listening to a teacher in a classroom or driving a car down the road, the ability to selectively attend to and remember only the most important objects in the environment is critical to making situation-appropriate decisions. Traditional accounts hold that selective attention and short-term memory are mediated by increasing or decreasing the firing rates (or the gain) of the neurons that encode currently relevant objects, analogous to adjusting the equalizer controls on a stereo to selectively enhance or suppress different features (i.e. power in different frequency bands). Here we will use modelling, psychophysics, and functional magnetic resonance imaging (fMRI) to test the alternative theory that flexible behaviors are supported by transformations in high- dimensional population codes that are driven by changes in the state of the sensory environment and by changes in behavioral goals.

PI_NAMEs: SERENCES, JOHN T (contact)

PROGRAM_OFFICER_NAME: WIGGS, CHERI

PROJECT_TERMS: active vision;Afferent Neurons;Area;Attention;Automobile Driving;Behavior;Behavioral;Cells;Clinical;Code;Diagnosis;Dimensions;Dissociation;Environment;experimental study;extrastriate visual cortex;flexibility;Frequencies;frontal lobe;Functional Magnetic Resonance Imaging;Goals;high dimensionality;Human;human subject;information processing;Intervention;Joints;Learning;Maps;Measures;Mediating;member;Memory;Modeling;Motion;Motor;neural;Neurons;Neurosciences;nonhuman primate;novel;Occipital lobe;operation;Outcome;Parietal Lobe;Pattern;Population;Prefrontal Cortex;prospective;Psychophysics;recruit;response;Response to stimulus physiology;Role;Rotation;Scheme;selective attention;Sensory;sensory input;sensory integration;Short-Term Memory;Signal Transduction;Stimulus;teacher;Testing;theories;United States National Institutes of Health;Visual;Visual Cortex;visual information;visual processing;Work

PROJECT_TITLE: Adaptive population codes for flexible visually-guided behaviors

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ADMINISTERING_IC: ES

ED_INST_TYPE: SCHOOLS OF PHARMACY

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Chronic Obstructive Pulmonary Disease;Climate-Related Exposures and Conditions;Lung

ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: NARRATIVE Uncontrolled inflammatory activity of macrophages is central to the pathophysiology of chronic diseases associated with exposure to air pollutants such as ozone. Our studies focus on elucidating mechanisms controlling proresolution activity of macrophages. Our goal is to harness these regulatory mechanisms to dampen runaway inflammation and reduce chronic disease.

PI_NAMEs: LASKIN, DEBRA L (contact)

PROGRAM_OFFICER_NAME: NADADUR, SRIKANTH

PROJECT_TERMS: Acute;Acute Lung Injury;Air Pollutants;Anti-Inflammatory Agents;Area;Asthma;bile acid metabolism;Bile Acids;blood glucose regulation;Cells;Child;Chronic;Chronic Disease;Chronic lung disease;Chronic Obstructive Pulmonary Disease;Classification;constriction;cytotoxic;Development;Disease;Elderly;Energy-Generating Resources;Exposure to;Functional disorder;Genes;Glycolysis;Goals;Health;Impairment;Individual;Inflammation;Inflammatory;Inflammatory Response;Inhalation;insight;Interleukin-1 beta;irritation;Ligands;Link;Lipids;Lung;lung development;Lung Diseases;lung injury;Macrophage;Macrophage Activation;Mediating;Mediator;Metabolic;metropolitan;MicroRNAs;Nitric Oxide;novel;novel strategies;NR4A1 gene;Nuclear Receptors;Oxidative Phosphorylation;Ozone;ozone exposure;Pathogenesis;Pathogenicity;Pathology;Phenotype;Play;Predisposition;prevent;Process;Production;Public Health;Pulmonary Emphysema;pulmonary function;Pulmonary Inflammation;Reactive Nitrogen Species;receptor;Repression;Resolution;response;Role;Signal Transduction;Smog;Testing;tissue injury;Tissues;TNF gene;Toxic effect;transcription factor

PROJECT_TITLE: Harnessing Inflammatory Macrophages to Thwart Lung Disease Caused by Chronic Ozone Exposure


NIH_SPENDING_CATS: HIV/AIDS;Infectious Diseases

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Our results show that the host protein CDC42, a key regulator of the cytoskeleton and of cellular polarity, is crucial for the spreading of HIV-1 among cells. Our application proposes an in-depth investigation of the roles of CDC42 and of its downstream effectors in HIV-1 replication. The proposed studies are relevant to public health, because they have the potential to identify vulnerabilities that can be exploited to inhibit an important but poorly understood mode of HIV-1 transmission.

PI_NAMEs: GOTTLINGER, HEINRICH  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: Actins;Antigen-Presenting Cells;CD4 Positive T Lymphocytes;CDC42 gene;cdc42 GTP-Binding Protein;Cell Line;Cell Polarity;Cells;Complex;Cues;cytokine;Cytoskeleton;Data;Drug Targeting;Eukaryotic Cell;Exocytosis;experimental study;Family;Filopodia;FMNL1 gene;Golgi Apparatus;Guanosine Triphosphate Phosphohydrolases;HIV;HIV-1;Human;immunological synapse formation;Infection;insight;Investigation;Knock-out;Life Cycle Stages;man;Mediating;Membrane;Microtubule-Organizing Center;Microtubules;Modeling;Molecular;Monomeric GTP-Binding Proteins;PAK-1 kinase;PARD6A gene;Peripheral Blood Mononuclear Cell;Phosphotransferases;polarized cell;Polymerase;polymerization;Polymers;Process;Protein Kinase;Proteins;Public Health;reconstitution;Reporting;response;Role;Secretory Vesicles;Signal Pathway;Site;Surface;synaptogenesis;T-Lymphocyte;trafficking;transmission process;Vesicle;Viral;Virion;virological synapse;Virus;Yeasts

PROJECT_TITLE: Role of cell polarity regulators in HIV spreading

STUDY_SECTION: HVCD

STUDY_SECTION_NAME: HIV Molecular Virology, Cell Biology, and Drug Development Study Section[HVCD]