ED_INST_TYPE: GRADUATE SCHOOLS

NIH_SPENDING_CATS: Behavioral and Social Science

ORG_CITY: RIVERSIDE

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: The Bridges to the Baccalaureate (B2B) will enhance public health by increasing the number of underrepresented in medicine and Science (URiMS) community college students in the biomedical sciences who complete their undergraduate degrees at 4-year universities.

PI_NAMEs: GARCIA-CASTRO, MARTIN I.;HERRICK, SCOTT ;RODGERS, VICTOR G.J. (contact)

PROJECT_TERMS: Address;African American population;Alaska Native;Area;Bachelor's Degree;Behavioral Sciences;bridge program;bridge to the baccalaureate;California;career;career awareness;Cities;college;community college;Compensation;design;Disadvantaged;disadvantaged student;Education;education research;experience;faculty mentor;Goals;Graduate Degree;Hawaiian;higher education;improved;Instruction;Intervention;Latino Population;matriculation;Medicine;Mentors;Mexican Americans;Native Americans;Occupations;Pacific Islander;peer coaching;Preparation;programs;public education;Research;Research Training;Resources;Science;science teacher;Services;socioeconomic disadvantage;STEM field;STEM program;Structure;Students;success;Training Programs;transfer student;Universities;university student

PROJECT_TITLE: Bridges to the Baccalaureate Research Training Program at University of California, Riverside

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: EY

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Biotechnology;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

ORG_CITY: GALVESTON

ORG_COUNTRY: UNITED STATES

ORG_DEPT: OPHTHALMOLOGY

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

ORG_STATE: TX

PHR: NARRATIVE Chemokine CXCL10 and its receptor CXCR3 are involved in the pathogenesis of many inflammatory diseases. Our proposed studies aim to understand the pathophysiological role of CXCL10/CXCR3 in cell-cell communication in glaucoma. This proposed research may identify new therapeutic strategies for glaucoma treatment.

PI_NAMEs: VARGAS, GRACIE ;XIA, FAN ;ZHANG, WENBO  (contact)

PROGRAM_OFFICER_NAME: SONG, HONGMAN

PROJECT_TERMS: antagonist;Astrocytes;Attenuated;Autoimmune;Axon;axonal degeneration;Binding;Blindness;Bone Marrow;C3AR1 gene;Cardiovascular Diseases;Cell Communication;Cell Death;cell injury;cell type;Cells;chemokine;chemokine receptor;Chronic;Clinic;Clinical Trials;Communication;Complement 3;conditional knockout;CXC chemokine receptor 3;CXCL10 gene;CXCR3 gene;Data;Degenerative Disorder;Disease;Disease Progression;Dominant-Negative Mutation;Family;Functional disorder;Gene Delivery;gene therapy;Glaucoma;Histology;Image;Immune;Immunologic Factors;Immunotherapeutic agent;In Vitro;Infiltration;Inflammation;Inflammatory;injured;Knockout Mice;Knowledge;Leukocyte Trafficking;Leukocytes;loss of function;Macrophage;Mediating;Membrane;Methodology;Microglia;Microspheres;Modeling;monocyte;mouse model;Mus;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neuroglia;Neuronal Injury;neuroprotection;non-invasive imaging;Non-Steroidal Anti-Inflammatory Agents;novel;novel therapeutic intervention;Optic Nerve;optic nerve disorder;Optic Nerve Injuries;Optics;Organism;Pathogenesis;Pathologic;Pathway interactions;Peptides;Phase I Clinical Trials;Physiologic Intraocular Pressure;Play;prevent;real-time images;receptor;recruit;Reperfusion Therapy;Research;Retina;retinal ganglion cell degeneration;Retinal Ganglion Cells;retinal ischemia;retinal neuron;Risk Factors;Role;Safety;Series;Signal Induction;Signal Transduction;Strategic Planning;System;T-Lymphocyte;targeted treatment;Testing;Therapeutic Intervention;Time;Tissues;translational potential;Up-Regulation;Vision

PROJECT_TITLE: CXCR3-Mediated Cell-Cell Communication in Glaucoma

STUDY_SECTION_NAME: Pathophysiology of Eye Disease - 2 Study Section[PED2]


ADMINISTERING_IC: DK

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Biomedical Imaging;Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Osteoporosis;Pediatric

ORG_CITY: BRONX

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Chronic kidney disease is associated with bone loss and fractures in both children and adults, but bone protective therapies that are both proven and safe to use across the life-course in CKD are lacking. In this study, we will conduct a pilot, double-blinded, randomized, placebo-controlled trial in 15 children and 88 adults evaluating the skeletal effects of potassium alkali therapy. These data will form the basis for a larger U01 proposal to determine the efficacy of potassium citrate on mitigating the effects of CKD on bone.

PI_NAMEs: KUMAR, JUHI ;MELAMED, MICHAL L;NICKOLAS, THOMAS L.;REIDY, KIMBERLY JEAN (contact)

PROGRAM_OFFICER_NAME: MENDLEY, SUSAN RUTH

PROJECT_TERMS: Acidosis;Acids;Adult;Alkalies;Architecture;Bicarbonates;Biopsy;bisphosphonate;bone;Bone Density;Bone Diseases;bone imaging;bone loss;bone quality;Bone remodeling;Bone Resorption;bone strength;bone turnover;C-terminal type I collagen telopeptide;Caring;Cell Culture Techniques;Child;Childhood;Chronic;Chronic Kidney Failure;circulating biomarkers;Clinical Trials;Cyclophosphamide;Data;Death Rate;density;design;Disease Management;Double-Blind Method;Dropout;Dual-Energy X-Ray Absorptiometry;efficacy evaluation;Epidemiology;Excretory function;experience;Fracture;Future;General Population;Health;Impairment;improved;innovation;Institution;Kidney;Kidney Diseases;Knowledge;Life Cycle Stages;Measures;Mechanics;Mediating;Medical center;Medicine;Metabolic acidosis;microCT;Minerals;Morbidity - disease rate;mortality;Multi-Institutional Clinical Trial;N-terminal;Nephrolithiasis;Nephrology;nephrotoxicity;Osteoclasts;Osteoporosis;Outcome;Pathogenesis;Patients;Pediatric Hospitals;pediatric patients;Peripheral;Pharmaceutical Preparations;pharmacologic;Pilot Projects;pilot trial;Placebo Effect;Placebos;Potassium;potassium citrate;Procollagen;PTH gene;Randomized;randomized placebo controlled trial;randomized, clinical trials;Renal Osteodystrophy;Reporting;Research;Resolution;Resources;response;Safety;Serum;Severity of illness;skeletal;Skeleton;Sodium;Sodium Bicarbonate;success;Supplementation;Symptoms;Testing;Therapeutic;Therapeutic Agents;Time;Tissues;treatment group;Universities;urinary;Urine;western diet;X-Ray Computed Tomography

PROJECT_TITLE: Bone In CKD Alkali Response Pilot Trial (BICARb Pilot Trial)

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences

ORG_CITY: NEW YORK

ORG_DEPT: BIOPHYSICS

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative A number of recent experimental observations suggest that complex brain functions in the mammalian brain emerge from highly parallel and distributed computation in which information about sensory inputs, internal states, and behavioral parameters are mapped onto brain-wide neuronal populations. Recording the activity of such brain-wide distributed populations of neurons at adequate speed and resolution across tissue depths has remained a superb challenge. Here we propose strategies for development, optimization, and broader dissemination of a new optical imaging technology for recording large-scale brain activity of awake and behaving rodents with potential to provide a major advance in our understanding of how cognitive brain functions emerge from neuronal activity across distributed brain circuits.

PI_NAMEs: VAZIRI, ALIPASHA  (contact)

PROGRAM_OFFICER_NAME: PUCAK, MICHELE LYNN

PROJECT_TITLE: Optimization, Application, and Dissemination of Imaging Modules for High-speed Mesoscopic Volumetric Recording of Neuroactivity in Scattering Brains


ADMINISTERING_IC: AI

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Data Science;Genetics;Infectious Diseases;Networking and Information Technology R&D (NITRD);Transplantation

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE The adaptive immune response is shaped by a constellation of factors including genetics, immune preparedness, and antigen exposure that can protect us from or predispose or drive us to illness. While isolated data repositories exist that cover each of these factors, the proposed work will harmonize, integrate, and enhance those resources to enable a holistic understanding of adaptive immune responses. The systems-level analysis made possible by this knowledge integration will improve public health by accelerating the use of adaptive immune repertoire data to develop new therapeutics, diagnostics, and patient monitoring.

PI_NAMEs: COWELL, LINDSAY G. (contact)

PROGRAM_OFFICER_NAME: BREEN, JOSEPH J

PROJECT_TERMS: Acceleration;adaptive immune response;Adaptive Immune System;Address;Adult;Age;Algorithms;Alleles;Antibodies;Antibody Formation;antigen binding;Antigens;application programming interface;Archives;Artificial Intelligence;Autoimmune;Autoimmune Diseases;Automation;Awareness;B-Cell Antigen Receptor;B-Lymphocytes;Base Sequence;Binding;Bioinformatics;Biological Assay;Biomedical Research;Cell Physiology;Clinical;clinical application;Common Data Element;Communicable Diseases;Communities;community building;Complex;Computational algorithm;Data;data acquisition;Data Commons;data complexity;Data Element;data integration;data modeling;data repository;Data Science;Data Set;data sharing;Databases;Demography;design;Development;Diagnostic;Disease;Ensure;Epitopes;Ethics;FAIR principles;FDA approved;Frequencies;Genbank;Generations;Genes;Genetic;Genetic Recombination;genomic locus;Genotype;Germ Lines;Goals;Graft Rejection;graft vs host disease;graphical user interface;Haplotypes;Human;Immune;immune reconstitution;Immunologic Monitoring;Immunologic Receptors;Immunologist;immunosenescence;improved;Influenza;innovation;interoperability;Kidney Transplantation;Knowledge;knowledge commons;knowledge integration;knowledgebase;Lymphocyte;Malignant Neoplasms;Maps;meetings;Meta-Analysis;Metadata;metadata standards;Monitor;neutralizing antibody;novel;novel therapeutics;novel vaccines;Ontology;Outcome;pathogen;Patient Care;Patient Monitoring;Population;Preparation;preservation;Procedures;Process;Production;Protocols documentation;Public Health;Publications;PubMed;Readiness;receptor;receptor binding;repository;Research;Research Personnel;Residual Neoplasm;Resources;response;Risk;Sampling;sex;Shapes;skills;Specificity;Stem cell transplant;System;T-Cell Receptor;T-Lymphocyte;Techniques;Therapeutic Monoclonal Antibodies;therapy design;tool;Training;Transplantation;Update;usability;Vaccine Design;Validation;Visualization;Work

PROJECT_TITLE: i-AKC: Integrated AIRR Knowledge Commons

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BBBT-T(55)]


NIH_SPENDING_CATS: Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Special gut proteins called proteases can harm intestinal function in patients with irritable bowel syndrome. We have discovered that healthy microbes in the gut suppress proteases, whereas, unhealthy microbes do not. We will determine which microbes are critical in suppressing proteases and how they do it. Lastly, we plan to demonstrate that replacing these good microbes improves intestinal barrier function offering a strategy to treat irritable bowel syndrome.

PI_NAMEs: GROVER, MADHUSUDAN  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Acute;Adult;Affect;Automobile Driving;Bacteria;Bacteroides;Beta-glucuronidase;Bilirubin;Biological Markers;Campylobacter jejuni;Chronic;Colon;commensal microbes;Communities;Coupled;Data;Development;Diarrhea;disabling symptom;dysbiosis;efficacy evaluation;Engraftment;enteric infection;Enterocolitis;Enzymes;Escherichia coli;experimental study;Family;fecal microbiota;Feces;Functional disorder;Funding;Germ-Free;gut bacteria;gut microbiota;Health;Healthcare Systems;Human;Human Activities;human microbiota;humanized mouse;Impairment;improved;In Vitro;in vivo;Infection;inhibitor;Intervention;intestinal barrier;Intestines;Irritable Bowel Syndrome;Link;Longitudinal Studies;Mediating;Mediator;Metabolism;Metagenomics;metaproteomics;Microbe;microbial;microbial community;microbiota;Morbidity - disease rate;mouse model;Mus;overexpression;Pathway interactions;Patients;Peptide Hydrolases;Play;Population;Prevotella;Protease Inhibitor;Proteins;Regulation;Regulation of Proteolysis;restoration;Risk;Risk Factors;Role;Serine Protease;Serine Proteinase Inhibitors;Source;stool sample;Structure;Symptoms;Testing;Tight Junctions;Time;Transplantation

PROJECT_TITLE: Microbiota based mechanisms of post-infection irritable bowel syndrome

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DNPD-A(01)]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Pediatric;Polycystic Kidney Disease

PHR: Project Narrative  In this study, we will investigate the functional roles and mechanisms of one of the DNA methyltransferase, DNMT1, in regulating cyst progression and address if a histone methyltransferases, SMYD2, serves as a recruitment platform for DNMT1 on specific gene methylation, thus highlighting a previously unrecognized direct connection between two key epigenetic repression systems. We will then test whether de-methylation of hypermethylated DNA mediated by DNMT1 and/or together SMYD2 with their inhibitors delays cyst growth in vivo. Accomplishing this project will lead to a better understanding of the mechanism of renal cyst formation and will provide novel therapeutic targets for ADPKD treatment.

PI_NAMEs: LI, XIAOGANG  (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Address;Affect;Apoptosis;Autosomal Dominant Polycystic Kidney;bisulfite sequencing;Body Regions;Cells;ChIP-seq;cilium biogenesis;conditional knockout;Cyst;Cystic kidney;demethylation;Disease Progression;DNA;DNA Methylation;DNA Methylation Regulation;DNA Modification Methylases;DNA Sequence Alteration;Enzymes;Epigenetic Process;epigenetic regulation;Epithelial Cell Proliferation;Epithelial Cells;Family;Feedback;FRAP1 gene;Gene Expression;Gene Proteins;Genes;Genetic;Genetic Transcription;Genome;genome-wide analysis;Growth;Histone Deacetylase;histone methylation;histone methyltransferase;Histones;Human;human disease;Human Genome;Hydralazine;Hypermethylation;in vivo;inhibitor;Investigation;Kidney;Kidney Diseases;Knock-out;Knockout Mice;Link;Lysine;Maintenance;Malignant Neoplasms;Mediating;Methylation;methylation pattern;Methyltransferase;Molecular;mouse model;Mus;mutant;Mutation;new therapeutic target;novel;Patients;Play;Polycystic Kidney Diseases;Process;protein function;recruit;Regulation;renal epithelium;Repression;Role;SET Domain;Severity of illness;Signal Pathway;Signal Transduction;STAT3 gene;survivin;System;Testing;Therapeutic;Tissues;TP53 gene;translational potential;Up-Regulation;whole genome

PROJECT_TITLE: The crosstalk of DNA and lysine methyltransferases in ADPKD.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-P(03)]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

ORG_CITY: CLEVELAND

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

ORG_STATE: OH

PHR: Relevance to Public Health Patients suffering from heart failure with preserved ejection fraction remain unaddressed because treatment options are lacking. This grant develops an entire new class of metabolic therapies aimed to target heart failure with preserved ejection fraction through engineered biomaterials and their interaction with immune cells shown to have important implications in this devastating disease.

PI_NAMEs: MAISEYEU, ANDREI  (contact)

PROGRAM_OFFICER_NAME: DANTHI, NARASIMHAN

PROJECT_TERMS: Activated Lymphocyte;Adaptive Immune System;Allogenic;Animals;Antigens;aorta constriction;Apoptosis;arginase;Biocompatible Materials;Biological Assay;Blood;Brain natriuretic peptide;Cardiac;Cardiotoxicity;CD28 gene;CD3 Antigens;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;cell motility;cell type;Cells;Chronic;Clinical Trials;clinically relevant;Coculture Techniques;Collagen;Collection;Congestive Heart Failure;coronary fibrosis;cytokine;Devices;Dexamethasone;Diagnosis;Disease;draining lymph node;Drug Delivery Systems;drug efficacy;Drug usage;Eating;Echocardiography;EFRAC;enantiomer;Engineering;Evaluation;Exclusion;experience;Fibrosis;Flow Cytometry;fluorescence imaging;Formulation;Genetic;Genus Hippocampus;Glycolysis;Goals;Grant;Heart;Heart failure;heart function;Heart Function Tests;Hepatotoxicity;Histology;Immune;immune activation;Immune Targeting;Immunization;Immunize;Immunomodulators;immunoregulation;Immunosuppression;Immunotherapy;improved;In Vitro;in vivo;in vivo evaluation;in vivo Model;Incidence;Infiltration;Inflammatory;inhibitor;Interferon Type II;Investigational Therapies;Lead;Left ventricular structure;Length;Leucocytic infiltrate;Ligands;Lipids;Liver;Lymphocyte Activation;Macrophage;Maintenance;Measurement;Measures;Medical;Metabolic;Metabolism;Modeling;monocyte;Morbidity - disease rate;mortality;mouse model;Mus;Myelogenous;Myocardial;Myocardial Degeneration;Myocardium;Myofibroblast;nanoparticle;NG-Nitroarginine Methyl Ester;novel therapeutic intervention;Organ;Oxidative Phosphorylation;Pathogenesis;Pathway interactions;Patients;Phenotype;Pilot Projects;Polymers;preservation;pressure;Prevalence;prevent;Probability;Proteins;Public Health;rational design;Reporter;response;Safety;Signal Transduction;Site;Spleen;success;Surface;Syndrome;T-Cell Activation;T-Lymphocyte;Testing;Therapeutic;therapeutic nanoparticles;Thymidine;Toxic effect;Treatment Failure;treatment guidelines;uptake;Work

PROJECT_TITLE: Non-racemic metabolic biomaterials for HFpEF

STUDY_SECTION: BMBI

STUDY_SECTION_NAME: Biomaterials and Biointerfaces Study Section[BMBI]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: Project Narrative Diverse perspectives in biomedical and behavioral research lead to greater innovation and greater recognition of issues that continue to threaten the health, well-being, and inclusion of underrepresented communities. Consequently, increasing the diversity of biomedical and behavioral research scientists increases our potential to address the most urgent public health challenges, and is critical to the full realization of our national research goals. The proposed SF2UF program would integrate activities between a two-year college and a major research university to expand the pool of traditionally underrepresented (UR) students who are considering a career as a research scientist, recruit UF trainees from this pool and place them in mentored research environments with experienced faculty mentors at the research university, and support these trainees through to their graduation with a B.S. degree and continuation to a successful career in biomedical and behavioral research.

PI_NAMEs: CRUZ-ALMEIDA, YENISEL ;JULIAN, DAVID  (contact);MARTINS, TALLINE ;MOODY, VERTIGO

PROGRAM_OFFICER_NAME: NELSON, SHAKIRA M

PROJECT_TERMS: Address;African American population;Alaska Native;American Indians;Bachelor's Degree;Behavioral Sciences;Black American;bridge to the baccalaureate;career;career development;college;community college;Degree program;design;Disabled Persons;disadvantaged background;Discipline;Disparity population;Doctor of Philosophy;Education;Enrollment;Ethnic Population;experience;Florida;Health;Hispanic Populations;Individual;Institution;Latino Population;matriculation;Measurable;Mental Health;Mentors;Native Hawaiian or Other Pacific Islander;novel;Performance;Postbaccalaureate;programs;racial population;recruit;Research;Science;Scientist;student retention;Students;Training;Training Programs;transfer student;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Institutes of Health;Universities;Well in self

PROJECT_TITLE: SF2UF: The Bridges to the Baccalaureate partnership between Santa Fe College and the University of Florida

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - C[TWD-C]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Rural Health;Social Determinants of Health

ORG_CITY: LAS VEGAS

ORG_NAME: SOUTHERN NEVADA CANCER RESEARCH FDN

ORG_STATE: NV

PHR: This state-wide program (that also has 3 out-of-state affiliates) provides access to cancer research in prevention, screening, post-treatment surveillance, treatment, imaging, biospecimen collection, health-related quality of life studies, cancer control, cancer care delivery research, and cancer disparities to all interested professionals from varied medical and academic disciplines for state-wide participation, thereby providing access for participation in NCI clinical trials to Nevada residents.

PI_NAMEs: ELLERTON, JOHN A (contact);IKEDA, ALAN

PROGRAM_OFFICER_NAME: WHITE, VANESSA

PROJECT_TERMS: Acceleration;Address;Adolescent and Young Adult;Advocate;Aftercare;anti-cancer research;base;biobank;California;cancer care;Cancer Control;cancer health disparity;cancer prevention;cancer therapy;care delivery;Caring;Cities;clinical trial enrollment;clinical trial participant;Clinical Trials;clinically significant;Collection;Communities;community based research;Community Clinical Oncology Program;Community Participation;Data;Development;Discipline;Disparity;Early Diagnosis;Educational Activities;Elderly;Enrollment;Environment;ethnic minority;Ethnic Origin;Foundations;Funding Opportunities;gender minority;Goals;Health Personnel;health related quality of life;Hematologist;high standard;Image;Incidence;insight;interest;Maintenance;Malignant Neoplasms;Medical;medical specialist;member;Michigan;Mission;Morbidity - disease rate;mortality;Names;National Cancer Institute;Nevada;Oncologist;Participant;participant enrollment;Patients;Physicians;Population;Prevention;programs;protocol development;Protocols documentation;Quality of life;Race;racial minority;Radiation Oncologist;rehabilitation management;Research;Research Activity;Research Design;Research Personnel;research study;Resources;rural dwellers;Safety;screening;Sexual and Gender Minorities;Site;Technology;Time;Underrepresented Populations;Underserved Population;welfare;Work

PROJECT_TITLE: NCI Community Oncology Research Program (NCORP) Community Sites (UG1 Clinical Trial Required)


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Pediatric;Sleep Research

ORG_CITY: PROVIDENCE

ORG_NAME: RHODE ISLAND HOSPITAL

ORG_STATE: RI

PHR: Project Narrative: Urban children with asthma are at high risk for short sleep, due to an environment that jeopardizes both sleep and asthma management. Further, urban children with asthma suffer from altered immune balance, a key biological process contributing to individual differences in asthma morbidity and sleep health. In the proposed research, we will examine the effects of shortened and recovery sleep on immune balance and associated changes in lung function in urban children with allergic asthma through an experimental design.

PI_NAMEs: KOINIS MITCHELL, DAPHNE  (contact);MARSHALL, GAILEN D.

PROGRAM_OFFICER_NAME: DIXIT, SHILPY

PROJECT_TERMS: actigraphy;Address;adequate sleep;Adult;Age;Allergic;Asthma;Beds;Biological Process;Chronic;Clinical;clinical care;cytokine;Data;Development;Disease;Enrollment;Environment;Equilibrium;experience;Experimental Designs;experimental study;Extrinsic asthma;Guidelines;high risk;high risk population;Home;Immune;immune function;Immunologic Markers;improved;improvement on sleep;Individual Differences;Inflammatory;Interferon Type II;Interferons;Interleukin-13;Interleukin-4;Interleukin-5;Interleukin-6;Interleukins;Intervention;Knowledge;Link;Modeling;modifiable behavior;Morbidity - disease rate;neglect;novel;Participant;Plasma;Play;Polysomnography;poor sleep;Population;Populations at Risk;Protocols documentation;pulmonary function;Pulmonary Function Test/Forced Expiratory Volume 1;Recovery;Research;Safety;Sampling;Schedule;Sleep;Sleep Deprivation;sleep health;Spirometry;Stress;Symptoms;Testing;Time;urban children;urban setting;Work

PROJECT_TITLE: Impact of Sleep Duration on Immune Balance in Urban Children with Asthma

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Aging;Bioengineering;Biotechnology;Cardiovascular;Heart Disease;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Narrative We seek to develop a biomimetic Hutchinson-Gilford progeria syndrome (HGPS)-on-a-chip system generated with patient-derived fibroblasts (FBs), SMCs, and endothelial cells (ECs) that allow application of relevant cyclic stretch for performing ‘clinical trials’ or informing clinical trial designs for HGPS patients.

PI_NAMEs: ZHANG, Y. SHRIKE  (contact)

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: absorption;Adsorption;age acceleration;Aging;Aorta;Aortic Valve Stenosis;Arteries;Atherosclerosis;Autopsy;Behavior;Biochemical;Biological Markers;Biomimetics;Biophysics;Biosensor;Blood Vessels;Cardiovascular system;Carotid Arteries;CAV1 gene;cell bank;Cells;Clinical Research;clinical trial on a chip;Clinical Trials;Clinical Trials Design;clinically relevant;cohort;Collagen;Combined Modality Therapy;Congestive Heart Failure;Cultured Cells;Devices;dosage;Dose;drug candidate;Elasticity;Elastin;Encapsulated;Endothelial Cells;experience;Extracellular Matrix;Fibroblasts;Genetic Diseases;Genetic Transcription;Goals;Human;Human body;Hydrogels;Hypertension;IL6 gene;improved;in vitro Model;in vivo;induced pluripotent stem cell;inflammatory marker;jun Oncogene;Lead;Liquid substance;Lonafarnib;Maintenance;Measurement;Mechanical Stress;Mechanics;Medial;Membrane;Methodology;Microfluidic Microchips;Microfluidics;Modeling;Monitor;monolayer;Morphology;mortality;Muscle Cells;Myocardial Infarction;non-invasive imaging;Optics;Outcome;Pathologic;patient derived induced pluripotent stem cells;Patients;Periodicity;Peripheral;Pharmaceutical Preparations;Phase;Phenotype;Physiological;polydimethylsiloxane;Polyurethanes;premature;Premature aging syndrome;prevent;Progeria;Publishing;Rare Diseases;Reporting;Resistance;response;response to injury;Scheme;screening;shear stress;Smooth Muscle Myocytes;Stretching;Structure;Symptoms;Syndrome;System;Technology;Thick;Thinness;Tissue Banks;Tissues;Translations;Tunica Adventitia;ultrasound;Vascular Smooth Muscle

PROJECT_TITLE: "Clinical Trials" on a Premature Vascular Aging-on-a-Chip Model


NIH_SPENDING_CATS: Digestive Diseases;Genetics;Pediatric;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: WORCESTER

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: UNIV OF MASSACHUSETTS MED SCH WORCESTER

PHR: In this project the investigators seek to understand novel mechanisms of embryonic development and postnatal growth control in the gastrointestinal tract. Our study is focused on gastrointestinal mesenchyme, a fundamentally important tissue layer within the gastrointestinal tract that is often understudied. The proposed studies on regulation of the critical YAP/TEAD signaling in gut mesenchyme are essential to gain mechanistic insights into and develop new therapeutic strategies for GI diseases.

PI_NAMEs: MAO, JUNHAO  (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Address;base;Biology;Chemicals;Chromatin;Chromatin Remodeling Factor;Complex;Cysteine;Data;Dependence;design;Development;Differentiation and Growth;Digestive System Disorders;Down-Regulation;Embryo;Embryonic Development;Endoderm;Endothelial Cells;Enhancers;Epithelium;Event;Family;fatty acylation;Fibroblasts;Functional disorder;Future;Gastrocoele;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal tract structure;Genetic;Genetic Transcription;Grant;Growth;Homeostasis;Human;in vivo;insight;intestinal epithelium;intestinal homeostasis;Intestines;Link;Malignant Neoplasms;Mediating;Mediator;Mesenchymal;Mesenchymal Stem Cells;Mesenchyme;Mesoderm;Modeling;Molecular;mouse genetics;mouse model;Muscle Development;Natural regeneration;NCOA3 gene;novel;novel therapeutic intervention;Organ Size;Organogenesis;Output;palmitoylation;Pathogenesis;Pathway interactions;Pattern;Physiological;Play;polyposis;postnatal;programs;Proteins;Publishing;recruit;Regulation;Reporting;Research Personnel;Role;self-renewal;Signal Transduction;small molecule inhibitor;Smooth Muscle;Smooth Muscle Myocytes;Specific qualifier value;stem cells;STK11 gene;Testing;therapeutically effective;Thinness;Time;Tissues;tool;transcription factor;Transcription Factor AP-1;Transcriptional Activation;Tube;Visceral;Work

PROJECT_TITLE: Dependence for TEAD transcription factors in intestinal development and polyposis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DKUS-A(90)]


NIH_SPENDING_CATS: Biotechnology;Obesity

ORG_CITY: IRVINE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA-IRVINE

ORG_STATE: CA

PHR: Project Narrative  Endocrine interactions have been demonstrated as causal and contributory to most common, most notably obesity, type 2 diabetes and resulting cardiovascular complications. The goal of this proposal is to closely bridge computational and experimental methods to systematically dissect mechanisms by which tissues communicate and how these interactions are perturbed in disease settings. Collectively, we will begin with newly developed and unbiased computational approaches which survey population data, validate using high-throughput in vitro assays and evaluate therapeutic potential of new endocrine interactions using mouse models of metabolic disease.

PI_NAMEs: SELDIN, MARCUS MICHAEL (contact)

PROGRAM_OFFICER_NAME: WANG, XUJING

PROJECT_TERMS: Address;Bayesian Network;Bioinformatics;bioinformatics pipeline;Cardiovascular system;cell type;Communication;Complex;computerized tools;Data;Disease;disease model;Dissection;Endocrine;Gene Expression;Genetic Variation;Goals;guided inquiry;high throughput screening;Human;in silico;in vitro Assay;in vivo;Individual;insight;Link;Machine Learning;Metabolic Diseases;Metabolism;Methods;mouse model;Mus;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;Organ;Organism;Pathway interactions;Plasma;Population;population survey;Proteins;Proteomics;Resources;Series;Signal Transduction;Signaling Molecule;success;Surveys;Therapeutic;Tissues;tool;Training;Validation;Variant;Visualization;Work

PROJECT_TITLE: Integrative approaches to dissection of endocrine communication


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Genetics

ORG_CITY: CAMBRIDGE

ORG_NAME: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

PHR: Project Narrative Human tumors frequently develop following environmental exposure to toxins and xenobiotics. These compounds result in DNA damage to epithelial cells and induce an inflammatory microenvironment. We believe that the protein kinase MK2, and a subset of critical RNA-binding proteins function as lynchpins connecting inflammation to cancer, and that therapeutic targeting of these molecule will both reduce the incidence of tumor formation in response to environmental/inflammatory stimuli, and dramatically enhance the ability of tumor cells to be killed by conventional anti-cancer agents. We also propose to characterize a poorly understood RNA damage response that is induced by environmental stress.

PI_NAMEs: YAFFE, MICHAEL B (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: Antineoplastic Agents;Apoptosis;Binding;biological adaptation to stress;cancer prevention;carcinogenesis;Cell Death;cell injury;Cells;Cellular Stress;cytokine;Cytokine Signaling;Data Set;Dedications;Development;DNA Damage;DNA Integration;Environmental Exposure;Environmental Health;Epithelial Cells;Epithelium;Exposure to;flexibility;Gene Expression;Genotoxic Stress;Goals;Human;Impairment;improved;in vivo evaluation;Incidence;Inflammation;Inflammatory;interest;Laboratories;Malignant Neoplasms;MAP Kinase Gene;MAPKAPK2 gene;Mediating;Mediator;Modeling;mouse model;neoplastic cell;novel;p38 Mitogen Activated Protein Kinase;Pathway interactions;Patients;Phosphoserine;Play;posttranscriptional;Production;protein function;Protein Kinase;response;RNA;RNA-Binding Proteins;Role;Signal Pathway;Signal Transduction;Stimulus;Stress;therapeutic target;Threonine;Tissues;Toxin;TP53 gene;tumor;tumorigenesis;Xenobiotics

PROJECT_TITLE: Protein Kinase Signaling in the Genotoxic Stress Response


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Prevention

ORG_CITY: LEXINGTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF KENTUCKY

ORG_STATE: KY

PHR: PROJECT NARRATIVE Many bacteria, including pathogenic Burkholderia species, utilize specific surface proteins to deliver an anti-bacterial protein toxin to neighboring bacteria upon direct cell-cell contact. Our proposed studies aim to determine the molecular requirements on both the `killer' and `target' cells for this inter-bacterial communication. By studying anti-bacterial proteins produced by these bacteria, this research will lay the foundation for the development of new antimicrobial therapies against Burkholderia and other antibiotic resistant bacteria.

PI_NAMEs: GARCIA, ERIN C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: Address;Adhesions;Anti-Bacterial Agents;antimicrobial;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Proteins;Behavior;Binding;Biogenesis;Biological;Biological Models;Burkholderia;Burkholderia pseudomallei;Cell Communication;Cell surface;Cell-Cell Adhesion;Cells;Communicable Diseases;Communication;Communities;Community Developments;Complex;Cytoplasm;Data;Decontaminant;Development;Discrimination;Disease Progression;disease transmission;Ecology;Escherichia coli;Family;Foundations;Future;Gene Expression;genetic approach;Goals;Gram-Negative Bacteria;Growth;Immune;Immunity;Infection;Infection prevention;insight;Investigation;Knowledge;Lipopolysaccharides;Mediating;Membrane;Membrane Proteins;Microbial Biofilms;microbial community;Modeling;Modification;Molecular;mouse model;new therapeutic target;novel therapeutic intervention;nuclease;Pathogenicity;Periodicity;Phenotype;Physiological;Play;Predisposition;prevent;Prevention;Process;protein function;Proteins;receptor;Receptor Cell;Research;Role;Shapes;Signal Transduction;social;Social Interaction;Structure;Surface;System;Systems Biology;Testing;Therapeutic;therapeutic target;Toxic effect;Toxin;Vaccines;Work

PROJECT_TITLE: Structure and function of Burkholderia contact-dependent growth inhibition (CDI) systems

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


ADMINISTERING_IC: MD

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dental, Oral, and Craniofacial Disease;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: Atlanta

ORG_NAME: KDH RESEARCH AND COMMUNICATION, INC.

ORG_STATE: GA

PHR: Primary and permanent tooth decay predicts lifelong oral health issues, and when left untreated, may produce pain, infection, and destruction of teeth and surrounding tissue, and myriad economic and social ramifications. Black children and adolescents in low-income households are at substantially greater risk for poor oral health outcomes. We will expand and test a culturally competent, online professional development course to prepare community health workers (CHWs) to provide oral health outreach to low-income Black parents/guardians of children and adolescents to build knowledge about oral health care and oral health resources, including how to navigate the oral health care system to prevent tooth decay and improve oral health across the lifespan.

PI_NAMEs: COOPER, DEXTER L (contact)

PROGRAM_OFFICER_NAME: BARKSDALE, CRYSTAL

PROJECT_TERMS: 2 arm randomized control trial;Address;Adolescence;Adolescent;Affect;Age;Applications Grants;Attitude;base;Belief;Black race;built environment;Child;commercialization;Communication;Communities;Community Health Aides;cost effective;course development;COVID-19 pandemic;cultural competence;deciduous tooth;Dental;Dental caries;Dental Health Education;design;Development;E-learning;Economics;education resources;effective intervention;Effectiveness;Emergency department visit;Equity;Evaluation;Evaluation Reports;evidence base;Evidence based program;experience;Exposure to;Film;Foundations;Funding;Goals;hands-on learning;Health;health disparity;Health Resources;Healthcare;Healthcare Systems;high risk;Hospitalization;Household;improved;Income;infancy;Infection;Infrastructure;Intervention;Journals;Knowledge;Learning;Left;life span;Link;Low income;Low Income Population;Market Research;Marketing;Methodology;Minority;Morehouse School of Medicine;Not Hispanic or Latino;online community;optimism;Oral health;Outcome;outreach;Pain;pandemic potential;Parents;Patients;Peer Review;permanent tooth;Persons;Phase;Poverty;prevent;Preventive;Professional Organizations;prototype;Provider;psychosocial;Publications;Publishing;Randomized, Controlled Trials;Reduce health disparities;Research;Resources;Risk;satisfaction;Self Efficacy;Services;skills;Small Business Innovation Research Grant;social;social health determinants;Solid;Source;symposium;System;Testing;Tissues;Tooth structure;Training;Trust;virtual education;Visit;Writing

PROJECT_TITLE: An online professional development course to train CHWs to provide oral health outreach to low-income Black guardians


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: Aurora

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Higher brain functions such as learning, memory and cognition require synaptic plasticity, i.e. the controlled changes in the strength of the connections between neurons. These functions require the Ca2+/calmodulin(CaM)-dependent protein kinase II (CaMKII) and are impaired both in normal aging and in Alzheimer's disease (AD), but to significantly different degrees. Preliminary studies indicate that the impairment in normal aging versus AD both involve mis-regulation of CaMKII, but by completely different mechanisms. These mechanisms will be tested further, with the ultimate goal to develop new therapeutic strategies for improving different cognitive impairments seen in the aging population.

PI_NAMEs: BAYER, K. ULRICH  (contact)

PROGRAM_OFFICER_NAME: LI, TONG

PROJECT_TERMS: abeta oligomer;Acute;Adult;Affect;age related;age related decline;Age-associated memory impairment;Aging;aging population;aging related;Alzheimer's Disease;Behavior;Behavioral;Binding;Brain;calmodulin-dependent protein kinase II;Chronic;Cognition;Excitatory Synapse;expectation;Goals;Hippocampus;Human;Image;Impaired cognition;Impairment;improved;Inhibitory Synapse;Intrabody;Knock-in Mouse;Learning;Long-Term Effects;Long-Term Potentiation;Mediator;Memory;Monitor;Movement;Mus;mutant;Mutant Strains Mice;Mutation;N-Methyl-D-Aspartate Receptors;Neurodegenerative Disorders;neuron loss;neuronal survival;Neurons;normal aging;novel therapeutic intervention;old mice;Pathologic;Phosphorylation;Prevention;Protein Dephosphorylation;Protein Phosphatase 2A Regulatory Subunit PR53;protein transport;Proteins;Quality of life;Risk;Stimulus;Synapses;synaptic function;Synaptic plasticity;Testing;Time

PROJECT_TITLE: CaMKII nitrosylation in the age-related decline of synaptic plasticity

STUDY_SECTION: NTRC

STUDY_SECTION_NAME: Neurotransporters, Receptors, and Calcium Signaling Study Section[NTRC-M]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Human Genome;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: Project Narrative The ability to manipulate the expression of genes in cells and organisms is foundational to the study of genetics and to the development of gene therapies, yet simple and scalable methods to increase gene expression remain challenging. Through a combination of innovative high- throughput screens and cutting-edge computational modeling, we will develop a cohort of CRISPR-based tools that enable potent, tunable, and predictable increases in gene expression at any gene. The efforts described in this proposal will provide a next-generation gene activation toolkit with broad applicability in genetic screening and therapeutic gene activation.

PI_NAMEs: SHERWOOD, RICHARD I (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Algorithms;Architecture;Biological Assay;Budgets;Candidate Disease Gene;Cell Line;cell type;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;cohort;Collection;Communities;Computer Models;CRISPR screen;CRISPR-mediated transcriptional activation;CRISPR/Cas technology;Data;data integration;deep learning;deep learning model;design;Development;Disease;Engineering;epigenome;epigenomics;gain of function;Gene Activation;Gene Expression;gene function;Gene Silencing;gene therapy;Generations;Genes;Genetic;genetic manipulation;Genetic Screening;Genetic study;Genetic Transcription;Genome;genome editing;Genomics;Guide RNA;HepG2;high throughput screening;High-Throughput Nucleotide Sequencing;Human;improved;Individual;innovation;K562 Cells;LDL Cholesterol Lipoproteins;Link;machine learning prediction;Measurement;Measures;Methods;Modeling;Monitor;Mus;next generation;novel;nuclease;Organism;Outcome;Output;Peptides;Phenotype;phenotypic data;predictive modeling;Productivity;promoter;recruit;Reporter;Repression;Reproducibility;Research;response;screening;Site;Stimulus;System;Testing;therapeutic gene;Tissues;tool;Transactivation;uptake;user-friendly;web-based tool;Work

PROJECT_TITLE: Development of potent and predictable Cas9 gene activation tools through high-throughput screening

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Neurosciences;Physical Injury - Accidents and Adverse Effects;Traumatic Brain Injury (TBI);Traumatic Head and Spine Injury

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Mild Traumatic Brain Injury (MTBI) is a major public health problem with U.S. annual incidence of over 2 million yet the underlying pathology remains unclear and clinicians cannot identify those who will have prolonged symptoms. Early studies often grouped a broad variety of symptoms together (e.g., cognitive, vestibular, oculomotor, behavioral), making it difficult to parse imaging markers sensitive to particular clinical symptom domains. This proposal aims to employ innovative MRI techniques to study microstructural and macrostructural injury as they specifically relate to cognitive symptoms in MTBI patients, translating promising evidence from cell and animal studies to a clinical MTBI population; the results of this investigation are expected to establish the dynamic longitudinal microstructural changes that occur after MTBI, investigating the link between white matter injury, cortical volume loss and cognition-specific outcomes.

PI_NAMEs: CHUNG, SOHAE ;LUI, YVONNE W (contact)

PROGRAM_OFFICER_NAME: UMOH, NSINI ALEASE

PROJECT_TERMS: Affect;Animals;Anisotropy;Attention;Axon;axon injury;Behavioral;behavioral health;Benchmarking;biomechanical model;biophysical properties;Biophysics;Brain;Brain Injuries;Cells;Clinical;clinical heterogeneity;clinically significant;Cognition;Cognitive;cognitive function;cognitive recovery;cognitive rehabilitation;Complex;Confusion;Corpus Callosum;debilitating symptom;Diffusion;Diffusion Magnetic Resonance Imaging;Disease;Elements;Evolution;experience;Fiber;Goals;head impact;Human;human model;Image;imaging biomarker;Impaired cognition;in vivo;Incidence;Injury;innovation;Investigation;Knowledge;Link;Literature;Magnetic Resonance Imaging;Measures;Mediating;Methods;mild traumatic brain injury;Modeling;Neurobehavioral Manifestations;novel;oculomotor;Outcome;outcome prediction;Parameter Estimation;Pathology;Patient Triage;Patient-Focused Outcomes;Patients;persistent symptom;Population;Process;processing speed;Protocols documentation;Public Health;rate of change;Recovery;Risk;Scheme;Short-Term Memory;Standard Model;Stretching;Structure;Symptoms;TBI Patients;Techniques;Testing;Therapeutic;Tissues;Translating;vestibular system;Water;white matter;white matter injury;Work

PROJECT_TITLE: Diffusion MRI Model Parameter Estimation to Study Brain Microstructure as it Relates to Cognitive Status in Mild Traumatic Brain Injury

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ORG_CITY: Columbus

ORG_DEPT: PHYSIOLOGY

ORG_NAME: OHIO STATE UNIVERSITY

PHR: PROJECT NARRATIVE This research program aims to advance our knowledge on myosin-3 motors, unique kinase-myosin hybrids that play crucial roles in the organization of the actin cytoskeleton in fundamental processes including hearing and vision. This research uses biochemical, biophysical, structural and cell biological approaches to understand the enzymology, regulation and interactome of myosin-3 motors. Results from this research are expected to provide detailed mechanistic insights into the role of myosin-3 motors in human health and disease.

PI_NAMEs: HEISSLER, SARAH  (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: Actins;Adopted;Binding;Biochemical;Biological;Biological Assay;Biological Process;Biophysics;Biotin;Bundling;Cell Physiology;Cells;Complex;Cryoelectron Microscopy;Cytoskeletal Modeling;Cytoskeleton;Disease;Enzymatic Biochemistry;Enzymes;Goals;Health;Hearing;Human;Human Biology;Hybrids;In Vitro;Individual;innovation;insight;internal control;Kinetics;Knowledge;Light;Link;Measurement;member;Molecular;Molecular Motors;monomer;Motility;Motor;Myosin ATPase;Myosin Light Chain Kinase;nanoscale;novel;Outcome;parallel architecture;Pathway interactions;Phosphotransferases;Physiological;Play;Process;programs;Protein Microchips;Protein-Serine-Threonine Kinases;Proteins;Regulation;Research;Resolution;Role;Sensory;Serine;Shapes;Signal Transduction;single molecule;Structure;synergism;Technology;Testing;Time;Vision;Work;X-Ray Crystallography

PROJECT_TITLE: Molecular Mechanisms of Myosin-3

STUDY_SECTION: MSFC

STUDY_SECTION_NAME: Macromolecular Structure and Function C Study Section[MSFC]


NIH_SPENDING_CATS: Cancer;Clinical Research;Hematology;Lymphatic Research;Lymphoma;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Rare Diseases

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative: NPM-ALK+ anaplastic large cell lymphomas are aggressive forms of pediatric mature T cell lymphoma and over 30% of patients experiences disease progression or relapse without robust prognostic biomarkers. Our studies will lead to development of simple blood-based robust and sensitive quantitatve assays that will help facilitate decisions about discontinuation of treatment and identify patients with risk of relapse.

PI_NAMEs: LIM, MEGAN S. (contact)

PROGRAM_OFFICER_NAME: AGRAWAL, LOKESH

PROJECT_TERMS: Accounting;Address;ALK gene;anaplastic lymphoma kinase;Autoantibodies;Biological Assay;Biological Markers;Biology;Blood;chemotherapy;Child;Childhood;Childhood Lymphoma;Chromosome abnormality;circulating biomarkers;Clinical;Clinical Trials;cohort;Combination Drug Therapy;constitutive expression;crizotinib;Detection;Development;digital;Disease;Disease Progression;Early identification;experience;Future;Genetic;Goals;high risk;Human;Immune response;Inflammatory Pseudotumor;Ki-1 Large-Cell Lymphoma;Lesion;Lymphoma;Malignant neoplasm of lung;Malignant Neoplasms;Mature T-Lymphocyte;Mediating;melanocyte;Methods;minimally invasive;Modeling;Molecular;Monitor;multidisciplinary;Mutation;Neuroblastoma;Newly Diagnosed;Non-Hodgkin's Lymphoma;novel;novel therapeutics;NPM1 gene;participant enrollment;Patients;Pediatric Oncology Group;peripheral blood;personalized diagnostics;phase 2 study;Plasma;Play;Population;Prognosis;prognostic;Prognostic Marker;prognostic significance;prognostic value;prognostication;Prophase;Protein Tyrosine Kinase;Randomized;Receptor Protein-Tyrosine Kinases;Recurrence;Relapse;relapse risk;Research;Research Personnel;Residual Neoplasm;Resources;response;Risk;Role;Sampling;specific biomarkers;Subgroup;t(2;5)(p23;q35);T-Cell Lymphoma;targeted treatment;Therapeutic Agents;Time;Toxic effect;Transcript;treatment response;tumorigenesis

PROJECT_TITLE: Circulating biomarkers of ALK+ anaplastic large cell lymphoma

STUDY_SECTION: CBSS

STUDY_SECTION_NAME: Cancer Biomarkers Study Section[CBSS]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

ORG_CITY: MISSOULA

ORG_NAME: UNIVERSITY OF MONTANA

ORG_STATE: MT

PHR: Project Narrative This research project will develop EmCAST (Empirical C-Alpha Stability Tool) for stabilization of proteins with unprecedented accuracy and make it available to the research community through a web service. The long- range impact of this work includes increasing the shelf life of protein pharmaceuticals and the ability to develop more robust biocatalysts and biosensors.

PI_NAMEs: BOWLER, BRUCE E (contact)

PROGRAM_OFFICER_NAME: GERSHENSON, ANNE

PROJECT_TERMS: Address;Affect;Algorithmic Software;Algorithms;Amino Acids;Attenuated;Binding;Biological Assay;Biosensor;Carbon;Communities;Complex;conformer;Data;Databases;Development;Directed Molecular Evolution;Equilibrium;Goals;immunogenicity;improved;innovation;Kinetics;Knowledge;Length;Life;Link;Measures;Methods;Molecular Conformation;mutant;Mutation;Output;Pharmacologic Substance;Positioning Attribute;predictive tools;preference;Probability;Protein Biochemistry;Protein Conformation;protein data bank;Protein Dynamics;protein folding;protein function;protein structure;Proteins;Publishing;rational design;Research;Research Project Grants;scaffold;Site;Solvents;Specificity;Structure;success;Surface;Testing;therapeutic protein;tool;Variant;Vertebral column;web server;web services;web-based tool;Work

PROJECT_TITLE: EmCAST: Stabilizing Proteins and Tuning Dynamics with High Precision and Accuracy

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Neurosciences

ORG_DEPT: OTHER BASIC SCIENCES

PHR: It is thought that many neurodevelopmental and neurodegenerative disorders, including ones that effect visual perception, lead to disruptions in synaptic integrity and stability, resulting in wiring deficits and perturbed brain function. We understand little regarding how disruptions in synapse formation and circuit connectivity arise, largely due to paucity of methods to visualize such events as they occur in vivo. In this proposal we combine innovative in vivo imaging technology and labeling methods with classical visual manipulations to establish a baseline characterization of the molecular events in excitatory synapse formation and stabilization, and investigate how the proteomic content of a synapse reflects its circuit identity, dynamic lifetime, and propensity for plasticity.

PI_NAMEs: NEDIVI, ELLY  (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Acids;Affect;Anatomy;Architecture;area striata;Binding;Brain;Brain Diseases;Cell Nucleus;Cells;Color;Development;Electroporation;Elements;Event;Excitatory Synapse;experience;extracellular;Extracellular Protein;Failure;fluorophore;functional adaptation;gene product;Genes;Glutamate Receptor;Glycosylphosphatidylinositols;Goals;hippocampal pyramidal neuron;Imaging technology;Impairment;in utero;in vitro Assay;in vivo;in vivo imaging;in vivo monitoring;Individual;innovation;Knockout Mice;Label;Lateral Geniculate Body;Lateral posterior nucleus of thalamus;Lead;Learning;Link;Maps;Mediator;Memory;Methods;Microscopy;Molecular;Monitor;mouse genetics;Mus;neural circuit;Neurodegenerative Disorders;Neurodevelopmental Disorder;Neurons;operation;Physiological;postsynaptic;postsynaptic density protein;presynaptic;prevent;protein complex;Proteins;Proteome;Proteomics;pup;receptor;Recording of previous events;recruit;response;Sensory;Specificity;stargazin;Synapses;synaptic function;synaptogenesis;Synaptophysin;Testing;Tissues;Transgenic Mice;Transmembrane Domain;two photon microscopy;ultra high resolution;Vertebral column;Visual;Visual Cortex;visual deprivation;Visual Perception;Visual System;Visualization

PROJECT_TITLE: Characterizing excitatory synapse in vivo structural dynamics

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biomedical Imaging;Eye Disease and Disorders of Vision;Genetics;Human Genome;Physical Injury - Accidents and Adverse Effects;Wound Healing and Care

ORG_CITY: GALVESTON

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: NARRATIVE The BETs play a key role in inflammation, neovascularization and fibrosis in many disease. This proposed studies aim to define the role of BETs in mustard-induced corneal injury using mouse and rabbit models of corneal NM burn.

PI_NAMEs: MOTAMEDI, MASSOUD ;ZHANG, WENBO  (contact)

PROGRAM_OFFICER_NAME: ARAJ, HOUMAM H

PROJECT_TERMS: Acetylation;Acute;analog;Anatomy;angiogenesis;Angiography;Antibodies;Binding;Bioinformatics;Biological Models;BRD2 gene;Bromodomain;Bromodomains and extra-terminal domain inhibitor;burn therapy;Chemical Injury;Chemical Weapons;Chronic;Clinical Research;Clinical Trials;Complex;Cornea;corneal burn;corneal epithelium;Corneal Injury;Corneal Opacity;cost;Data;Defect;Development;Disease;Disease Management;Edema;effective therapy;Effectiveness;efficacy evaluation;Endothelial Cells;Epigenetic Process;Epithelium;ETS1 gene;Eye Injuries;Fibrosis;Gene Expression;Genes;Genetic Transcription;genomic profiling;Histone Acetylation;Histones;Human;Imaging Techniques;Immune response;Immunohistochemistry;in vivo;Individual;Inflammation;Inflammatory;inhibitor;injured airway;Injury;insight;Intervention;limbal;Lysine;Mechlorethamine;Mediating;Modeling;Molecular;Monitor;mouse model;Mus;Mustard;Mustard Gas;N-terminal;neovascularization;novel;Nucleosome Core Particle;ocular imaging;Optical Coherence Tomography;Oryctolagus cuniculus;Pathway interactions;Patients;Persons;pharmacologic;Phase;Phosphorylation;Physiological;Play;Positive Transcriptional Elongation Factor B;Process;Production;Protein Family;Reaction;Reader;Reagent;Recovery;recruit;Reporting;response;RNA Polymerase II;Role;Safety;Scaffolding Protein;severe injury;Severities;Skin injury;success;Tail;Terrorism;Testing;Testis;Topical application;Transcript;Transcription Coactivator;transcription factor;transcriptome sequencing;Transforming Growth Factor beta;translational potential;Vascular Endothelial Growth Factors;Vesicants;Visual impairment;Work

PROJECT_TITLE: The Role of Master Epigenetic Regulators in Ocular Chemical Injury


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Aging;Immunotherapy;Infectious Diseases;Lung;Pneumonia;Pneumonia and Influenza;Prevention

ORG_CITY: PITTSBURGH

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: III. PROJECT NARRATIVE Human metapneumovirus (HMPV) is a debilitating infection and leading cause of severe respiratory infections in young children, the elderly, and the immunocompromised. The specific mechanism behind the impaired immune response to HMPV in the elderly leading to severe respiratory disease is incompletely understood. In this proposal, I aim to elucidate the age-specific differences in the immune response to HMPV in the lung utilizing the aged murine model to identify candidate molecules/pathways that ultimately can be clinically translatable and targeted in an HMPV vaccine as well as the management and treatment of related respiratory viruses afflicting the elderly.

PI_NAMEs: PARKS, OLIVIA  (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: 2019-nCoV;adaptive immunity;Adoptive Transfer;Age;age difference;age related;aged;Alveolar Macrophages;Bioinformatics;Biological Assay;Body Weight decreased;Bone Marrow;candidate identification;career;CD8-Positive T-Lymphocytes;CD8B1 gene;Cell Communication;cell type;Cells;Chest;Child;Chimera organism;chromatin modification;Clinical;clinical translation;Coculture Techniques;Color;Communicable Diseases;Coronavirus;cytokine;Data;Development;Dichloromethylene Diphosphonate;Disease;Elderly;Epigenetic Process;Exhibits;experimental study;Flow Cytometry;Functional disorder;Functional impairment;Funding;Genes;Genetic Transcription;Goals;Hospitalization;Human Metapneumovirus;Immune;Immune response;Immunity;Immunocompromised Host;Immunologics;Immunology;immunoregulation;Impairment;improved;In Vitro;Infection;Inflammatory;Influenza;Isogenic transplantation;Knowledge;Label;Laboratories;life span;Liposomes;Literature;Lower Respiratory Tract Infection;Lung;Macrophage;Mediator;Molecular Target;monocyte;Morbidity - disease rate;mortality;mouse model;multiple omics;Mus;Natural Immunity;Neonatal;neutralizing antibody;novel;old mice;older adult;Pathogenesis;Pathway interactions;Persons;Population;Populations at Risk;Predisposition;prevent;Prevention;Primary Infection;Principal Investigator;programmed cell death protein 1;Pulmonary Inflammation;reconstitution;Reporting;Research;Research Personnel;respiratory;Respiratory Disease;respiratory pathogen;Respiratory syncytial virus;Respiratory Tract Infections;respiratory virus;Role;Scientist;Seasons;secondary infection;secondary lymphoid organ;Severities;Severity of illness;Signal Transduction;single cell ATAC-seq;single-cell RNA sequencing;skills;T cell response;T-Lymphocyte;Technical Expertise;Testing;Tissues;tool;Training;training opportunity;Translating;Vaccines;Viral;Virus;Virus Replication;Vulnerable Populations;Weight Gain;Western Blotting

PROJECT_TITLE: Age-dependent differences in the immune response to human metapneumovirus

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F07A-H(20)]


ORG_CITY: LONG BEACH

ORG_NAME: CALIFORNIA STATE UNIVERSITY LONG BEACH

PHR: Project Narrative The Bridges to the Doctorate Training Program at California State University, Long Beach will partner with University of California, Irvine to form a seamless bridge to support biomedical Master’s degree students transitioning to Ph.D. programs. Both universities have a highly-diverse student population and rigorous STEM programs, nationally recognized for their excellence. This proposal describes curriculum and activities at both CSULB and UCI that aim to develop a strong sense of science identity and belonging along with superb research design and technical skills.

PI_NAMEs: BRUSSLAN, JUDY ANN (contact);MOTA-BRAVO, LUIS M

PROGRAM_OFFICER_NAME: MCINTYRE, JEREMY COLIN

PROJECT_TERMS: bridge to the doctorate;California;Research Training;Training Programs;Universities

PROJECT_TITLE: Bridges to the Doctorate Research Training Program at California State University Long Beach

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Bipolar Disorder;Brain Disorders;Clinical Research;Depression;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

PHR: Project Narrative  New treatments are needed for bipolar disorder (BD), a lifelong illness in ~3% of United States adults that is associated with disability, chronic medical problems, and premature death. Transcranial magnetic stimulation (TMS) is a focal, non-invasive form of brain stimulation that shows promise for BD, but the optimal brain regions to target for mania, depression, or mood stabilization are unclear. The purpose of this project is to derive treatment targets for BD using brain lesions that cause mania or depression, and to validate these lesion- derived targets in patients with BD using functional neuroimaging and behavioral testing.

PI_NAMEs: TAYLOR, JOSEPH JEFFREY (contact)

PROGRAM_OFFICER_NAME: CHAVEZ, MARK RAY

PROJECT_TERMS: Address;Adult;Affective;affective disturbance;behavior test;Behavioral;behavioral phenotyping;biomedical imaging;Biometry;Bipolar Disorder;Brain;brain circuitry;Brain Mapping;Brain region;career;Case Study;catalyst;Center for Translational Science Activities;Cessation of life;Chronic;Clinical;Clinical Research;Clinical Trials;cohort;connectome;Data;Data Science;Data Set;design;disability;Disease Management;Effectiveness;emotion regulation;Emotional;Enhancing Lesion;follow-up;Functional disorder;Funding;Future;Goals;Grant;Hospitals;Human;insight;Intervention;Investigational Therapies;Learning;Left;Lesion;Localized Lesion;Location;Manic;Maps;Masks;Measures;Medical;medical schools;Mental Depression;Mentors;Modeling;Mood Disorders;Moods;Morbidity - disease rate;mortality;National Institute of Mental Health;Network-based;Neuroanatomy;neuroimaging;novel;older patient;optimal treatments;Outcome;Patient imaging;Patients;Phenotype;Physicians;Prefrontal Cortex;premature;Process;programs;psychiatric symptom;Psychiatry;Research;Research Methodology;Scientist;Services;side effect;Strategic Planning;Symptoms;Techniques;Testing;Therapeutic;therapeutic evaluation;tool;Training;Transcranial magnetic stimulation;Translational Research;Unipolar Depression;United States;Woman;Work

PROJECT_TITLE: Deriving TMS Targets for Mood Valence and Mood Stabilization in Bipolar Disorder

STUDY_SECTION: NPAS

STUDY_SECTION_NAME: Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section[NPAS]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;Prevention;Prostate Cancer;Urologic Diseases

ORG_CITY: HONOLULU

ORG_NAME: UNIVERSITY OF HAWAII AT MANOA

ORG_STATE: HI

PHR: PROJECT NARRATIVE  Prostate cancer is the second most commonly diagnosed malignancy in men, and there are urgent needs to identify causally related protein biomarkers and build improved prediction models for prostate cancer risk and aggressiveness. The proposed study will identify causally related protein biomarkers for prostate cancer using an innovative design of combining novel statistical methods and functional characterization and develop improved prostate cancer prediction models across Africans and Europeans using novel methods. Knowledge generated by this project will not only significantly contribute to the etiologic understanding of prostate cancer, but also have potential utility in improving its risk/aggressiveness assessment in Africans and Europeans.

PI_NAMEs: WU, CHONG ;WU, LANG  (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Address;African;African ancestry;Area;Assessment tool;Basic Science;Biological;Biological Assay;Biological Markers;biomarker identification;Blood;Brain;Cancer Biology;Cancer Etiology;candidate identification;candidate marker;Cell Line;Cessation of life;Clinical;Complex;Data;Death Rate;Derivation procedure;design;Development;Diagnosis;Dietary Factors;Disease;DNA Methylation;epidemiologic data;epidemiology study;Ethnic Origin;Etiology;European;European ancestry;Freezing;Gene Expression;Genes;Genetic;genetic predictors;Growth;Hematopoietic Neoplasms;high risk population;Histologic;improved;Incidence;innovation;Invaded;Knowledge;lifestyle factors;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methodology;Methods;Methylation;model building;Modeling;multiple omics;non-genetic;novel;Other Genetics;Outcome;Patients;Performance;Predictive Cancer Model;predictive modeling;programs;Prospective cohort;Prostate;prostate cancer risk;protein biomarkers;protein expression;Proteins;racial population;Reduce health disparities;Regulator Genes;Reporting;Research Design;Research Support;Risk;Risk Factors;risk prediction;risk prediction model;Role;screening;Screening for Prostate Cancer;Selection Bias;Series;Statistical Methods;Testing;Tissues;transcriptome;Validation;Work

PROJECT_TITLE: Uncovering causal protein markers to improve prostate cancer etiology understanding and risk prediction in Africans and Europeans

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: NARRATIVE Overall The Core Grant for Vision Research provides support and facilities which are not available and cannot be obtained through individual grants to 24 vision research investigators at Baylor College of Medicine, carrying 19 eligible NEI RO1s. The Core facilities are used to study how visual system disorders, such as retinitis pigmentosa, age-related macular degeneration, glaucoma, amblyopia and strabismus occur and to determine what neuronal and synaptic mechanisms in the visual system are responsible for the pathogenesis of these disorders.

PI_NAMEs: WU, SAMUEL M (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Age related macular degeneration;Amblyopia;Animals;Area;behavior test;Biochemical;Biochemistry;Bioinformatics;Cells;Chimeric Proteins;Chromium;Collaborations;college;Complex;Computer software;computerized;Computers;Confocal Microscopy;Core Facility;Core Grant;Cornea;Custom;Dedications;design;design and construction;Developmental Biology;Devices;digital imaging;Discipline;Disease;Electron Microscope;Electron Microscopy;Electronics;Electrophysiology (science);Eligibility Determination;Environment;Equipment;Equipment Design;experience;Eye;fabrication;flexibility;Fluorescent Dyes;Fostering;Functional disorder;Funding;Generations;Genes;genomic profiling;Genomics;Glaucoma;Grant;High Pressure Liquid Chromatography;Histologic;Histology;human genome sequencing;Human Resources;Image;Immunofluorescence Immunologic;improved;Individual;innovation;Institution;instrumentation;Joints;Label;Laboratory Research;lens;Light Microscope;Mass Spectrum Analysis;Mechanics;Medicine;Microscope;Microscopy;Molecular;Molecular Genetics;Mus;Mutation;neural;Neurons;Nucleic Acids;Ophthalmology;Optics;Oryctolagus cuniculus;Paper;patch clamp;Pathogenesis;Physiological;Postdoctoral Fellow;Process;Productivity;programs;Proteins;Psychophysics;Publications;Publishing;Rattus;Reagent;recruit;Reporting;Research;research facility;research faculty;Research Personnel;Research Project Grants;Research Training;Resolution;Resources;Retina;Retinitis Pigmentosa;Scanning;Services;single cell genomics;square foot;Strabismus;Structure;Students;Synapses;System;Systems Analysis;Technology;Thick;Three-Dimensional Imaging;Time;Tissue imaging;Tissues;Training;transmission process;two-dimensional;United States National Institutes of Health;Vision;Vision research;Visual;visual neuroscience;Visual System;water maze

PROJECT_TITLE: P30 - Core Grant for Vision Research


NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PHR: NARRATIVE Administrative Module The Core Grant for Vision Research is directed by Samuel M. Wu, PhD, who will be assisted by a Core Grant Advisory Committee, consisting of himself, module directors Drs. Pflugfelder, Ching-Kang Chen and Rui Chen and an Administrative Associate, Ms. Jessica Nollkamper. The Vison Core provides support and facilities which are not available or cannot be obtained through individual grants to 24 vision research investigators at Baylor College of Medicine. The facilities in the Core modules will be used to study how visual system disorders, such as retinitis pigmentosa, age-related macular degeneration, glaucoma, amblyopia and strabismus occur and to determine what neuronal and synaptic mechanisms in the visual system are responsible for the pathogenesis of these disorders.

PROJECT_TERMS: Advisory Committees;Age related macular degeneration;Amblyopia;Animals;Archives;Bioinformatics;Biophysics;Books;Budgets;Capital;college;Computer software;Contract Services;Core Facility;Core Grant;digital imaging;Disease;Doctor of Philosophy;Equipment;experience;Faculty;Funding;Genomics;Glaucoma;Grant;Histology;Human Resources;Individual;instrumentation;Maintenance;Medicine;meetings;Microscopy;Molecular;Monitor;Neurons;Neurosciences;Occupations;operation;Ophthalmology;Oral;Pathogenesis;Performance;Physiology;Process;professor;Records;repaired;Reporting;Research Personnel;Resources;Retina;Retinitis Pigmentosa;Salaries and Fringe Benefits;Services;Strabismus;Synapses;Systems Analysis;Time;Update;Vision;Vision research;Visual System;web site;Work;Writing

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Social Determinants of Health

ORG_CITY: CHESTNUT HILL

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: BOSTON COLLEGE

PHR: PROJECT NARRATIVE Cognitive impairment and Alzheimer’s disease and related dementias (ADRD) are major public health issues in the United States that are expected to burden an increasing number of older adults and their families in the coming decades. This proposal will examine how characteristics of the social context shape trajectories of cognition and ADRD, focusing on changes in social networks, social activities, and neighborhood social infrastructure, and the roles of olfactory functioning and inflammation as potential mechanisms. The results of this project will inform research on the social pathways of sensory and cognitive functioning, and illuminate the social context as a potential site of intervention for preventing or slowing age-related cognitive decline.

PI_NAMEs: GOLDMAN, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: age effect;age related;age related changes;age related decline;Age-associated memory impairment;Aging;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;analytical method;Area;Award;Biological;Brain;Buffers;burden of illness;career;Chronic;Cognition;Cognitive;cognitive ability;Cognitive aging;cognitive function;Data;Development;Diagnosis;Disease;Disparity;Distal;experience;Exposure to;Family;Future;Goals;Grant;Health;Home;Impaired cognition;improved;Inflammation;Inflammatory Response;Infrastructure;innovation;insight;Intervention;Knowledge;late life;Life;Link;longitudinal analysis;Longitudinal Studies;Measures;Mentored Research Scientist Development Award;Mentorship;Methods;middle age;Neighborhoods;novel;older adult;Pathway interactions;Patients;Physiological;Physiology;Population Study;Prevalence;prevent;Process;programs;Public Health;rapid growth;Research;Research Activity;Research Design;Research Personnel;Risk;Role;Sampling;Sensory;sensory system;Shapes;Site;skills;Smell Perception;social;Social Characteristics;social determinants;Social Environment;social factors;social learning;Social Network;social relationships;social science research;Social support;sociologist;Source;Survey Methodology;theories;Time;Training;Training Activity;United States;Vision;Work;Writing

PROJECT_TITLE: Integrating the Social Context, Sensory Functioning, and Inflammation in a Longitudinal Study of Cognitive Aging and Alzheimer's Disease and Related Dementias

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurodegenerative;Neurosciences

PROJECT_TERMS: Advisory Committees;Age related macular degeneration;Amblyopia;Chronic;college;Computer software;computerized;Computers;Core Grant;Custom;design;design and construction;Device Designs;Devices;Disease;Doctor of Philosophy;Electrodes;Electronics;Equipment;experience;experimental study;fabrication;flexibility;Glaucoma;Grant;Implant;improved;Individual;innovation;instrumentation;Mechanics;Medicine;micromanipulator;Microscope;Modification;Neurons;Noise;Optics;Pathogenesis;Play;Process;Reflex action;Research;Research Personnel;Research Project Grants;Retinitis Pigmentosa;Role;Services;Strabismus;Synapses;System;tool;two-photon;Vision;Vision research;Visual System

PROJECT_TITLE: Instrumentation Module


NIH_SPENDING_CATS: Bioengineering;Eye Disease and Disorders of Vision;Neurosciences

PHR: NARRATIVE Microscopy, Digital Imaging and Histology Module High-resolution digital imaging of cells and tissues is essential for the translational disease modeling performed by the Vision Core investigators. ThisMicroscopy, Digital Imaging and Histology module provides the latest imaging technology and expert support to investigators for their studies of visual system morphology, disease pathogenesis and therapeutic efficacy.

PI_NAMEs: PFLUGFELDER, STEPHEN C (contact)

PROJECT_TERMS: Animals;Cell Culture Techniques;Cell Physiology;Cells;cellular imaging;Chimeric Proteins;Collaborations;college;Complex;Computer software;Confocal Microscopy;Core Facility;Core Grant;digital imaging;Disease;disease model;efficacy evaluation;Electron Microscope;Electron Microscopy;Fluorescent Dyes;high resolution imaging;Histologic;Histology;Image;imaging capabilities;Imaging technology;Immunofluorescence Immunologic;improved;instrument;Label;Light;Light Microscope;Medicine;Microscope;microscopic imaging;Microscopy;Modeling;Molecular;Morphology;multi-photon;neural;Neurons;novel therapeutic intervention;Nucleic Acids;Pathogenesis;Process;Proteins;Reagent;Research Personnel;Resolution;Sampling;Scanning;Services;Stains;Thick;Three-Dimensional Imaging;Tissue imaging;Tissues;Training;transmission process;Treatment Efficacy;two-dimensional;Vision;Vision research;Visual System

PROJECT_TITLE: Microscopy & Digital Imaging Core


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Neurosciences

ORG_NAME: DUQUESNE UNIVERSITY

PHR: PROJECT NARRATIVE Every researcher benefits from understanding what has been done previously by other scientists prior to beginning their own scientific investigation. The proposed project, the creation of freely available educational modules on the topic of evidence synthesis, aims to help scientists do this. Creating better literature review skill sets among scientists means less wasteful research is generated and a higher likelihood of improving public health.

PI_NAMEs: COVVEY, JORDAN RANDALL (contact);GIONFRIDDO, MICHAEL ROSS

PROGRAM_OFFICER_NAME: CRAWFORD, DEVON CHRISTINE

PROJECT_TERMS: Active Learning;Address;advanced system;Area;base;Basic Science;Brain;Clinical Research;Clinical Sciences;Communities;Concept Review;Data;Databases;design;Development;digital;Disease;Education;education resources;Educational Curriculum;Elements;Equity;Evaluation;Evaluation Studies;Evidence based practice;experience;Failure;Feedback;Goals;Grant;Health;Human;improved;Individual;inquiry-based learning;interest;Investigation;Investments;Knowledge;learning engagement;Learning Module;learning outcome;Licensing;Literature;Manuscripts;member;Methodology;Methods;Mind;Mission;National Institute of Neurological Disorders and Stroke;Nervous System;Nervous System Disorder;novel;open data;Patients;peer;Persons;pre-clinical;prevent;Process;Proliferating;Protocols documentation;Public Health;Publishing;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Research Proposals;Resources;response;Review Literature;Risk;Science;Scientist;Self Efficacy;Series;skills;Source;Structure;syntax;systematic review;Techniques;Text;text searching;Time;tool;Training;translational pipeline;undergraduate student;Universities;wasting;Work

PROJECT_TITLE: Enhancing experimental rigor through education in evidence synthesis


PHR: NARRATIVE Small Animal Visual System Analysis Module Successful modeling of human blinding diseases is required for finding effective cures. This Small Animal Visual System Analysis Module provides instrumentation and expert services to help investigators characterize vision disease mechanisms and gauge therapeutic efficacy in small animal models.

PI_NAMEs: CHEN, CHING-KANG JASON (contact)

PROJECT_TERMS: Animal Model;Animals;Behavior;behavior test;Biochemical;Biological Assay;Collaborations;college;Core Grant;Disease;Electroretinography;Equipment;Explosion;Functional disorder;genome editing;High Pressure Liquid Chromatography;human disease;human model;in vivo;Individual;instrumentation;Investigation;Mass Spectrum Analysis;Medicine;Mus;Mutation;Optical Coherence Tomography;Oryctolagus cuniculus;patch clamp;Physiological;Postdoctoral Fellow;Rattus;Reflex action;Research Personnel;Services;student training;Systems Analysis;Technology;Testing;Therapeutic Intervention;Training;Treatment Efficacy;Vision;Vision research;Visual System;water maze;Western Blotting

PROJECT_TITLE: Small Animal Visual System module


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Dementia;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences

ORG_CITY: STANFORD

ORG_DEPT: PATHOLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Alzheimer's disease (AD) is an age- and neurodegenerative related disease estimated to affect five million or more of the ageing American population by 2050. There is thus an urgent need to identify unique predictive signatures that correlate with developing AD. By using multi- parametric measurements with enabling technologies like multiplexed ion beam imaging (MIBI) we will be able to uncouple unhealthy brain senescence, that could be therapeutically targeted, from that associated with the normal aging process.

PI_NAMEs: BENDALL, SEAN CURTIS (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: abeta accumulation;Address;Affect;African Green Monkey;Age;age related;age related neurodegeneration;age-related disease;aged;Aging;aging brain;aging process;aging related;Alzheimer's Disease;Alzheimer's disease brain;American;Antibodies;area striata;Astrocytes;Automobile Driving;Axon;Biochemical;Blood Vessels;Brain;Brain imaging;Brain region;brain tissue;Cell Aging;cell injury;Cells;Cerebellum;Cerebral cortex;Cessation of life;Clinical;Clinical Pathology;Cognitive;cohort;collaborative approach;Communities;Complex;Data;deep learning;Dementia;Dendrites;disability;Disasters;Disease;Disease Marker;entorhinal cortex;Family;Funding;Health Policy;Healthcare Systems;healthy aging;Heterogeneity;high dimensionality;Hippocampus;Human;human model;Image;imaging platform;Immune;Impaired cognition;Inferior;Infrastructure;Injury;innovation;insight;invention;Label;Lobule;loss of function;Machine Learning;Maps;Measurement;Metabolic;Metals;Microglia;middle age;mild cognitive impairment;Modeling;Molecular and Cellular Biology;molecular imaging;molecular phenotype;Multiplexed Ion Beam Imaging;nanometer resolution;nanoscale;Nerve Degeneration;Nervous System Physiology;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;neuronal cell body;Neurons;neuropathology;nonhuman primate;normal aging;novel;novel imaging technique;Oligodendroglia;Parietal;Pathology;Pattern;Phenotype;Policy Maker;Population;postmitotic;predictive signature;Predisposition;prevent;programs;Proteins;Proteomics;Public Health;release factor;Research;Research Personnel;Resistance;response;Risk Factors;Running;Sampling;senescence;senescent cell;Senile Plaques;Severities;shared database;Specimen;stressor;Synapses;tau Proteins;Technology;therapeutic target;Time;Tissues;Tonsil;Validation;vervet

PROJECT_TITLE: Uncoupling Age- Versus Cognitive-Related Cellular Senescence in Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-A(50)R]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Genetics;Human Genome;Neurosciences

PHR: NARRATIVE Genomics and Bioinformatics Module The Genomics and Bioinformatics Module is an important resource that addresses the increasing need of the vision researchers at Baylor College of Medicine to access the state-of-the art genomic technologies that are not available in individual laboratories and provides critical bioinformatics support in deciphering the vast amount of data. This module will leverage the expertise, technologies, and resources at the BCM Human Genome Sequencing Center (BCM-HGSC), one of the three major genome centers in the US. In addition to providing service, the module will also serve as a key mechanism to introduce cutting edge genomics and single cell technologies to vision researchers.

PI_NAMEs: CHEN, RUI  (contact)

PROJECT_TERMS: Acceleration;Address;Bioinformatics;Biology;ChIP-seq;Chromium;Collaborations;college;Complex;Computational Biology;Core Grant;cost;Data;Data Analyses;Disease;DNA sequencing;DNA Sequencing Facility;epigenomics;experience;Experimental Designs;experimental study;Fostering;Gene Expression;Genes;Genetic;Genome;genomic profiling;Genomics;human genome sequencing;Human Resources;Individual;invention;Laboratories;Libraries;Malignant Neoplasms;Medicine;miRNA expression profiling;Molecular Biology;Mutation Detection;next generation;next generation sequencing;Positioning Attribute;Production;Research Personnel;Resources;Services;single cell genomics;single cell sequencing;single cell technology;single-cell RNA sequencing;Speed;System;Technology;Training;transcriptome sequencing;Vision;Vision research;Visual System;Work

PROJECT_TITLE: Genomics & Bioinformatics Module


ADMINISTERING_IC: NR

ED_INST_TYPE: SCHOOLS OF NURSING

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Caregiving Research;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Palliative Care

ORG_CITY: Chicago

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF ILLINOIS AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative Patients with advanced cancer have not fully benefited from advance care planning due to the high levels of anxiety and depression experienced and other barriers that affect their appraisals and coping. Despite the protective effects of resilience, there have been few clinical trials improving the resilience skills of patients with advanced cancer and their family caregivers to help initiate advance care planning discussions and sustain engagement. This research will provide new insights through using a dyadic intervention approach to advance care planning while developing and evaluating a web-based resilience- building intervention to improve the completion of advance directives, resilience, coping, anxiety, and depression for patients with advanced cancer and their family caregivers.

PI_NAMEs: LONGCOY, LI-TING HUANG (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;Adolescent and young adult cancer patients;Advance Care Planning;advanced directive;Advanced Malignant Neoplasm;Affect;Anxiety;Award;Awareness;behavior change;Cancer Center;Caregivers;Caring;Clinical Trials;Communication;comparative efficacy;coping;Coping Skills;cost;Data;Decision Aid;Decision Making;design;Development;digital;dissemination science;Distress;Emotional;emotional distress;empowerment;end of life care;experience;Family Caregiver;Feeling;Foundations;Future;Goals;health goals;Health Professional;Healthcare;Hospice Care;implementation science;improved;Individual;insight;Intervention;Knowledge;Malignant Neoplasms;Medical;Mental Depression;Modeling;mortality;Online Systems;Outcome;Palliative Care;Parents;Pathway interactions;Patients;Persons;Phase;pilot test;Play;Positioning Attribute;primary outcome;Process;promote resilience;protective effect;Psychology;quality of death;randomized, clinical trials;Randomized, Controlled Trials;Reaction;Research;Research Design;resilience;Risk;Role;satisfaction;secondary outcome;Secure;skill acquisition;skills;Symptoms;tenure track;Testing;theories;therapy development;Training;Transact;treatment as usual;Treatment Efficacy;Uncertainty;usability;web-based intervention

PROJECT_TITLE: Facilitating Advance Care Planning Discussions Between Patients with Advanced Cancer and Their Family Caregivers Using a Resilience-Building Intervention

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: Nursing Science Review Committee[NRRC(85)]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetic Testing;Genetics;Human Genome;Lung;Lung Cancer;Nanotechnology;Precision Medicine;Prevention

ORG_CITY: CHAMPAIGN

ORG_DEPT: GENETICS

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: Narrative Rapid and quantitative detection of KRAS circulating tumor DNA (ctDNA) from blood with a simple workflow and inexpensive instrument will open opportunities for point of care therapy selection and remission monitoring. To address limitations of sensitivity, sequence specificity, cost, and complexity of existing technologies, this project will develop and rigorously characterize a digital-resolution biomolecular sensing technology combined with an isothermal CRISPR/Cas-based amplification process to achieve multiplexed detection of mutant genes with <0.001% mutant allele frequency. The approach is applicable to broad classes of ctDNA for many forms of cancer with FDA-approved targeted therapies, and even more cancers for minimal residual disease monitoring.

PI_NAMEs: CUNNINGHAM, BRIAN T. (contact);MANSFIELD, AARON SCOTT;WANG, XING

PROGRAM_OFFICER_NAME: SORG, BRIAN S

PROJECT_TERMS: Address;Aftercare;assay development;Base Sequence;Biological;Biological Assay;Biosensing Techniques;Biosensor;Blood;Blood Plasma Volume;Calibration;cancer biomarkers;Cancer Detection;Cell Physiology;Clinical;clinical efficacy;clinical practice;clinically relevant;Clonal Evolution;Clustered Regularly Interspaced Short Palindromic Repeats;Colorectal Cancer;comparative;Complement;cost;design;design,build,test;Detection;detection limit;detection sensitivity;Development;Diagnosis;Diagnostic;Diagnostic tests;digital;Discrimination;Disease;Disease remission;DNA;DNA Markers;DNA Sequence;DNA Sequence Alteration;Effectiveness;Elements;FDA approved;Fluorescence;follow-up;Gene Frequency;Genes;genetic variant;genomic biomarker;Genomics;Guide RNA;Hour;Human;improved;innovation;insight;instrument;KRAS2 gene;Laboratories;Link;liquid biopsy;Malignant neoplasm of lung;Malignant neoplasm of pancreas;Malignant Neoplasms;Measurement;Measures;Methods;Microscopy;Molecular;Molecular Abnormality;Monitor;multiplex detection;mutant;Mutation;Mutation Detection;nanoGold;next generation sequencing;novel;nucleic acid detection;Nucleic Acid Probes;Nucleic Acids;Office Visits;Performance;Pharmaceutical Preparations;photonics;Plasma;point of care;point-of-care detection;point-of-care diagnostics;portability;pressure;Process;Protocols documentation;Rapid diagnostics;Recommendation;Recurrence;Reference Standards;Residual Neoplasm;Resolution;RNA Probes;Sampling;screening;Screening for cancer;Selection for Treatments;sensor technology;Single-Stranded DNA;Slide;Specificity;Specimen;Surface;System;targeted treatment;Technology;technology platform;Testing;Time;Tissues;tool;treatment effect;Tube;tumor;Tumor Biology;tumor DNA;Validation;Variant

PROJECT_TITLE: Rapid, simple, and ultrasensitive quantitation of KRAS ctDNA at the point of care using CRISPR/Cas amplification and digital resolution biosensor microscopy


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

ORG_CITY: MINNEAPOLIS

ORG_NAME: UNIVERSITY OF MINNESOTA

PHR: Project Narrative (Public relevance statement) This project enhances understanding of developmental language disorder within diverse populations. Children with developmental language disorder have different profiles of language deficits that reflect their language-learning environments, but they may share common underlying deficits in basic cognitive processing skills such as attention, memory, and processing speed. This project will investigate these processing skills at the individual level in monolingual and bilingual school-age children with and without developmental language disorder and determine whether deficits in cognitive processing skills can contribute to effective identification of developmental language disorder in children who have different language- learning experiences.

PI_NAMEs: EBERT, KERRY DANAHY (contact)

PROGRAM_OFFICER_NAME: STORKEL, HOLLY LYNN

PROJECT_TERMS: 7 year old;Address;Affect;aged;Area;Attention;Auditory;bilingualism;Characteristics;Child;Child Language;Childhood;Clinical;Clinical Services;clinical translation;Cluster Analysis;Cognitive;Development;developmental disease;diagnostic accuracy;Disease;disparity reduction;educational atmosphere;Ensure;Exhibits;experience;Future;Goals;Home;improved;Individual;innovation;Language;Language Development;Language Development Disorders;Language Disorders;Linguistics;Measurement;Measures;Memory;Methods;Modality;Modeling;novel;Participant;Pathway interactions;Pattern;peer;Population;Population Heterogeneity;Prevalence;prevent;processing speed;Property;Psychometrics;recruit;Research;Sampling;School-Age Population;selective attention;Short-Term Memory;skills;Societies;Spanish/English;Specificity;Stimulus;Testing;theories;Validity and Reliability;Vietnamese;Visual;Work

PROJECT_TITLE: Nonlinguistic cognitive processing commonalities among linguistically diverse learners with developmental language disorder

STUDY_SECTION: LCOM

STUDY_SECTION_NAME: Language and Communication Study Section[LCOM]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: NOTRE DAME

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF NOTRE DAME

ORG_STATE: IN

PHR: Project Narrative The proposed research is relevant to public health because the novel computational models developed will be able to leverage experimental data to help answer fundamental biological questions about the causes and effects of inﬂammatory swelling. Computational models are essential for understanding the complexity of biological systems, and offer safe and effective methods for the testing of hypotheses. Therefore, the project is relevant to the NIGM's mission of increasing our understanding of biological processes and laying the foundation for advances in disease, diagnosis, treatment, and prevention. 1

PI_NAMEs: HOLLAND, MARIA  (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TITLE: Computational Biomechanics Modeling of Inflammation


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Biotechnology;Complementary and Integrative Health;Natural Products

ORG_CITY: LA JOLLA

ORG_DEPT: ZOOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: Public Health Relevance Statement Natural product compounds occupy a central role in medicine in providing lifesaving drugs. Supply challenges however often constrain the biomedical potential of promising bioactive natural products from rare or environmentally sensitive marine organisms. Our discovery of the first terpenoid biosynthesis genes in marine animals and amongst the first in marine algae towards flagship bioactive molecules like the anti-inflammatory pseudodopterosin and anticancer halomon offers a path to bioengineering drug leads from marine organisms from sustainable laboratory microbial fermentation.

PI_NAMEs: CHANG, GEOFFREY A;MOORE, BRADLEY S (contact)

PROGRAM_OFFICER_NAME: BOND, MICHELLE RUEFFER

PROJECT_TERMS: Acceleration;Address;Algae;Anabolism;Animals;anti-cancer;Anti-Inflammatory Agents;Antineoplastic Agents;Bacteria;bioactive natural products;Biochemical Reaction;Biochemistry;Biological;Biomedical Engineering;Biotechnology;Calculi;Cells;Chemicals;Chemistry;Clinical;Collection;Communicable Diseases;Complex;coral;Crystallography;Cytochrome P450;deep ocean;Development;Diphosphates;drug development;drug discovery;Environment;Enzymatic Biochemistry;enzyme biosynthesis;Enzymes;Escherichia coli;Eukaryota;Evaluation;Family;fascinate;Fermentation;frontier;Gene Cluster;Genes;Genetic Engineering;Genome;Genomics;Goals;halogenation;Isoprene;Knowledge;Laboratories;Life;Link;Logic;Malignant Neoplasms;manufacture;marine;Marine Invertebrates;marine natural product;marine organism;Medicine;metabolomics;Methods;Microbe;microbial;Microbial Genetics;Mining;Modernization;Molecular;multidisciplinary;Natural product discovery;Natural Product Drug;Natural Products;novel therapeutics;Outcomes Research;Pain;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Plants;preclinical evaluation;Production;programs;Property;Protein Biochemistry;Protein Overexpression;Proteins;pseudopterosins;public health relevance;Recombinant Proteins;Red Algae;Research;Research Project Grants;Resources;Role;scaffold;Science;Scientist;Structure;synthetic biology;terpene synthase;Terpenes;Terpenoid Biosynthesis Pathway;tool;transcriptomics;Vanadium;Vertebral column;Work;X-Ray Crystallography;Yeasts

PROJECT_TITLE: Biosynthesis of marine terpenoid natural products

STUDY_SECTION: CSB

STUDY_SECTION_NAME: Chemical Synthesis and Biosynthesis Study Section[CSB]


NIH_SPENDING_CATS: Natural Products;Neurosciences;Opioids

PHR: NARRATIVE By modulating the activity of ligand gated ion channels (LGICs) and G-protein coupled receptors (GPCRs), complex natural products have the potential to reveal critical insight into the function of these therapeutically important membrane receptors. This proposal investigates the synthesis and evaluation of two classes of natural products and their development into new chemical tools to investigate LGIC and GPCR pharmacology. By providing new directions to rationally design small molecules that engage their receptors targets, the results from this research will ultimately lead to safer, more effective medicines.

PI_NAMEs: RILEY, ANDREW  (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Agonist;Alkaloids;Area;Award;Biological Assay;Biological Process;Chemicals;Complex;Coupling;Development;drug discovery;Economics;Evaluation;Family;Future;G-Protein Signaling Pathway;G-Protein-Coupled Receptors;Health;Human;improved;Indole Alkaloids;inhibitor;insight;Ion Channel Gating;kappa opioid receptors;Laboratories;Libraries;Ligands;Medicine;member;Membrane;Methods;Monitor;Natural Products;Natural Source;Nicotinic Receptors;novel;Opioid;Pharmacology;Protocols documentation;rational design;receptor;Research;Route;scaffold;Signal Transduction;small molecule;Synthesis Chemistry;Techniques;Therapeutic;tool;Work

PROJECT_TITLE: Synthesis and Evaluation of Alkaloids to Probe Membrane Receptors