ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Machine Learning and Artificial Intelligence

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative This research project will deliver innovative computational tools to identify genes and regulatory elements responsible for specific organismal traits. These tools will enable researchers around the world to assign functional elements to phenotypes of importance to human health and disease, including longevity, neurological function, metabolism, and congenital diseases of development. These genetic inferences will also provide new directions for the research community to pursue a fundamental understanding of biological systems.

PI_NAMEs: CHIKINA, MARIA D;CLARK, NATHANIEL L (contact)

PROGRAM_OFFICER_NAME: WETTERSTRAND, KRIS A

PROJECT_TERMS: Address;analysis pipeline;Behavioral;Benchmarking;Binding;Binding Sites;Biological;biological systems;Biology;Birds;Body Size;Characteristics;Codon Nucleotides;Collection;Communities;comparative genomics;Computer software;computerized tools;cost;Data Set;design;Development;Disease;DNA Sequence;DNA Transposable Elements;Elements;Epigenetic Process;Evolution;experience;Experimental Genetics;Fertilization;fungus;Gene Expression;Genes;Genetic;genetic element;Genetic Research;Genome;genome annotation;genomic data;genomic platform;Genomic Segment;Genomics;Genotype;Goals;Growth;Growth and Development function;Habitats;Hair;Health;Human;improved;innovation;large datasets;life history;life span;Link;Longevity;Machine Learning;machine learning method;Mammals;marine;Medical Genetics;Metabolic;Metabolism;Methodology;Methods;Modeling;Morphology;Mus;Nervous System Physiology;next generation;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Open Reading Frames;Output;Partner in relationship;Phenotype;Phylogenetic Analysis;Physiological;predictive modeling;Primates;programs;Property;Regulatory Element;reproductive;Research;Research Personnel;Research Project Grants;Rodent;Role;Site;Specificity;Speed;sperm cell;Structure;Taxonomy;Testing;Testis;tool;trait;transcription factor;Untranslated RNA;Validation;Yeasts

PROJECT_TITLE: Title: Functional Annotation of Genomes via Phenotypic Convergence within Large Multi-species Alignments


ADMINISTERING_IC: GM

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Amyotrophic Lateral Sclerosis (ALS);Brain Disorders;Genetics;Neurodegenerative;Rare Diseases

ORG_CITY: Columbus

ORG_COUNTRY: UNITED STATES

ORG_DEPT: CHEMISTRY

ORG_FIPS: US

ORG_NAME: OHIO STATE UNIVERSITY

ORG_STATE: OH

PHR: PROJECT NARRATIVE Dysregulated RNA biology figures prominently in many neurodegenerative diseases for which there are currently poor treatment options, including amyotrophic lateral sclerosis (ALS). The proposed research is significant because it will contribute a set of transformative tools for study of RNA-governed biology in ALS and related neurodegenerative diseases. If successful, our approach would open new potential therapeutic and diagnostic avenues for treating neurodegenerative diseases such as ALS.

PI_NAMEs: BONG, DENNIS  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Adolescent;ALS pathology;Amyotrophic Lateral Sclerosis;Antibodies;Area;Attention;Benchmarking;Binding;Biology;Biotin;Biotinylation;C9ALS;C9ORF72;Cell Line;Cells;cellular imaging;Chemicals;Complex;crosslink;Cytoplasmic Granules;Data;Diagnostic;Disease;Dyes;early onset;Evaluation;Face;Fluorescence;Genetic Transcription;Goals;In Vitro;insight;Investigation;Label;Link;Location;Methods;Modification;Neurodegenerative Disorders;Nucleic Acid Probes;nucleic acid structure;Pathologic;Patients;Peptide Nucleic Acids;Plasmids;Property;Prosthesis;protein TDP-43;Proteins;Publishing;Regulatory Pathway;Research;Ribonucleoproteins;RNA;RNA Folding;RNA-Binding Proteins;Site;Streptavidin;Structure;Subcellular structure;System;Testing;Therapeutic;tool;trafficking;Transcript;Transfection;Validation;Variant;Western Blotting

PROJECT_TITLE: URIL tags for intracellular RNA tracking and RNP proximity labeling

STUDY_SECTION: CBP

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


ADMINISTERING_IC: MD

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: FAMILY MEDICINE

ORG_NAME: UNIVERSITY OF CHICAGO

ORG_STATE: IL

PHR: Project Narrative Women with criminal records have alarmingly high rates of behavioral health concerns and a majority experience forms of interpersonal violence victimization, yet women commonly do not receive needed behavioral health treatment and supportive services. This proposed mixed-methods study builds upon existing empirical work and a theoretically driven framework of help-attainment to examine how behavioral health, interpersonal victimization, and collateral consequences shape help-seeking and help-attainment processes for treatment and services among adult women with criminal records. The findings will identify novel facilitators to help-attainment and intervention directions to improve the behavioral health and wellbeing of women with criminal records.

PI_NAMEs: FEDOCK, GINA LORRAINE (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Address;Adult;Adult women;Age;aged;Anxiety;behavior measurement;behavioral health;behavioral health intervention;Calendar;Caring;Communities;convict;Data;depressive symptoms;design;Development;Employment;Exclusion;experience;Face;Feeling suicidal;Future;Gender;Grant;health inequalities;Health Services;Healthcare;help-seeking behavior;Illinois;Imprisonment;improved;Individual;Inequity;innovation;Interpersonal Violence;Intervention;Interview;intimate partner violence;Jail;Knowledge;Legal system;Life Cycle Stages;life history;marginalization;Measures;Mental Depression;Mental Health;Mental Health Services;Methodology;Methods;Morbidity - disease rate;mortality;novel;Online Systems;Participant;Pattern;Personal Satisfaction;Persons;Phase;Policies;Post-Traumatic Stress Disorders;Prisons;Process;Provider;Race;Recording of previous events;Records;recruit;Reporting;Research;research and development;Research Methodology;Resources;Sampling;service providers;Service setting;Services;Sex Orientation;sexual assault;Shapes;social stigma;Structure;substance use;substance use treatment;Suicide attempt;Supervision;Surveys;Testing;theories;therapy development;Time;United States;Victimization;violence victimization;Woman;Women's Health;women's outcomes;women's treatment;Work

PROJECT_TITLE: The Impact of Collateral Consequences on Help-Seeking and Help-Attainment for Behavioral Health Needs for Women with Criminal Records

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Neurosciences;Sarcopenia

ORG_DEPT: NEUROSCIENCES

ORG_STATE: PA

PHR: Project Narrative: Falls in the elderly most often result from frailty, which is caused by muscle weakness, impaired balance, and unstable walking. Studies in rodents have shown that age-induced changes that lead to frailty are preceded by structural and functional changes at the neurotransmitter release site within the neuromuscular junction. This proposal aims to utilize several new approaches to understand how aging alters neuromuscular synapses at an individual transmitter release site level.

PI_NAMEs: MERINEY, STEPHEN D (contact)

PROGRAM_OFFICER_NAME: ST  HILLAIRE-CLARKE, CORYSE

PROJECT_TERMS: Acetylcholine;Adult;Age;age related changes;aged;Aging;aging population;aging process;Calcium Channel;Cause of Death;Centers for Disease Control and Prevention (U.S.);Computer Simulation;Data;density;DNA;Elderly;Electrophysiology (science);equilibration disorder;Equilibrium;experience;fall risk;falls;frailty;Future;Gait;Global Change;Goals;Heterogeneity;human old age (65+);imaging approach;Imaging Techniques;Individual;Injury;Measurement;Measures;Microscopy;Minor;Modeling;Motor;Motor Neurons;mouse model;Mus;Muscle;muscle form;Muscle function;muscle strength;Muscle Weakness;Muscular Atrophy;Neurologic;neuromuscular;Neuromuscular Junction;neurotransmitter release;Neurotransmitters;new therapeutic target;novel strategies;old mice;Optical reporter;Optics;Phase;Play;Population;presynaptic;recruit;reduced muscle strength;Reporting;Resolution;Risk;Risk Factors;Rodent;Role;sarcopenia;Site;Stains;Structure;superresolution imaging;Synapses;synaptic function;Synaptic Vesicles;targeted treatment;Testing;Therapeutic Intervention;therapy development;Time;ultra high resolution;voltage;Walking

PROJECT_TITLE: Presynaptic active zone alterations that underlie dynapenia at aged mouse neuromuscular junctions

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]


ADMINISTERING_IC: HD

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Congenital Structural Anomalies;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Nutrition;Pediatric;Prevention

ORG_CITY: HOUSTON

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE The developing neural tube is vulnerable to changes in maternal metabolism, yet how maternal- fetal nutrient exchange is regulated in the visceral yolk sac, the functional equivalent of the placenta during neural tube closure, is not well understood. When the neural tube does not develop properly, the results are catastrophic for human survival and quality of life. The proposed project will identify how the yolk sac regulates maternal-fetal nutrient exchange and development of the neural tube.

PI_NAMEs: KEULS, RACHEL ANNE (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Ablation;absorption;Address;Attention Deficit Disorder;autism spectrum disorder;Bilateral;Biological Assay;Birth;Blood Cells;Brain;brain control;CD 200;cell motility;Cell Separation;Cell surface;Cells;cellular microvillus;Cephalic;Coculture Techniques;cranium;Data;Defect;Development;Differentiated Gene;Disease;dopaminergic neuron;Dyslipidemias;Embryo;Endoderm;Event;experience;Failure;Fatty Acids;fetal;Fetus;Flow Cytometry;Folic Acid Antagonists;Folic Acid Deficiency;Glucose;Goals;Growth;Harvest;Heme;Human;Hyperglycemia;Image;in utero;Intellectual functioning disability;Link;Lipids;Luciferases;maternal hyperglycemia;Maternal-Fetal Exchange;Measures;Mesoderm;Metabolic;Metabolism;metabolomics;MicroRNAs;Morphogenesis;Mus;nerve stem cell;Neural tube;Neural Tube Closure;Neural Tube Development;Neurodevelopmental Disorder;Neuroepithelial;Neuroepithelial Cells;neuroepithelium;neurogenesis;Neurological disability;Neuronal Differentiation;Neurons;neuroregulation;novel strategies;novel therapeutic intervention;Nutrient;nutrient absorption;Pathway interactions;PDGFRA gene;Phagocytosis;Phenotype;Placenta;Pregnancy;Prevalence;prevent;Prevention;Process;Quality of life;recruit;Role;Scanning Electron Microscopy;SOX1 gene;spatiotemporal;Structural defect;Tamoxifen;Tissues;Tomatoes;transcriptome sequencing;Transmission Electron Microscopy;Unhealthy Diet;United States;uptake;Visceral;WNT Signaling Pathway;Work;Yolk Sac

PROJECT_TITLE: Yolk Sac MicroRNAs Regulate Brain Development

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-Q(20)L]


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Mental Health;Mental Illness;Pediatric;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Serious Mental Illness;Social Determinants of Health;Women's Health Research

ORG_CITY: WASHINGTON

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

ORG_STATE: DC

PHR: PROJECT NARRATIVE There is increasing awareness that psychosocial factors contribute to the persistent racial/ethnic and socioeconomic disparities in pediatric asthma care and health outcomes despite the existing and highly effective NIH national guidelines for standardized care. Maternal depression is associated with poor pediatric asthma outcomes, and there is a need to examine if treating it, particularly when integrated within the context of ongoing pediatric asthma care, improves subsequent asthma management and health outcomes for under- resourced, urban, Black children. The proposed study fills this gap by studying the integration of Enhanced Brief Interpersonal Psychotherapy (a promising depression treatment for depression for mothers who are under-resourced) into ongoing community-based asthma care and evaluating its feasibility, acceptability, and preliminary efficacy on reducing maternal depression and child asthma morbidity and increasing health equity.

PI_NAMEs: MARGOLIS, RACHEL H.F. (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: access disparities;Address;Affect;anti-depressive agents;Appointment;Asthma;Awareness;Behavior Therapy;Behavioral;behavioral health;Black race;care coordination;Caregivers;Caring;Child;Child Health;Childhood;Childhood Asthma;Chronic;Clinic;Clinical;Clinical Trials Design;Communities;community based treatment;Complex;Depression screen;depressive symptoms;Discipline of obstetrics;Disease Management;Disparity;effective therapy;efficacy testing;ethnic disparity;ethnic minority;experience;Face;Family;Focus Groups;Frequencies;Goals;group intervention;Guidelines;Health;health care model;health care service utilization;health care settings;health disparity;health equity;health equity promotion;health inequalities;Health Professional;Health Services;implementation science;Improve Access;improved;informant;innovation;integrated care;interpersonal therapy;Intervention;Interview;Knowledge;Learning;maternal depression;Medical;medication compliance;Mental Depression;Mental Health;Mental Health Services;Mentors;Methods;Modeling;modifiable risk;Moods;Morbidity - disease rate;Mothers;multidisciplinary;Outcome;outcome disparities;Participant;Pediatrics;physical conditioning;Physicians;pilot trial;poor health outcome;Population;Pregnant Women;Primary Care;primary care provider;primary outcome;Process;provider-level barriers;psychosocial;Psychosocial Factor;Public Health;Published Comment;racial disparity;racial minority;Randomized;Reporting;Research;Resources;Risk Factors;routine screening;satisfaction;Scientist;Screening procedure;skills;social;socioeconomic disparity;standardize guidelines;standardized care;success;Symptom Burden;Symptoms;Training;translational scientist;treatment as usual;Treatment Efficacy;United States National Institutes of Health;uptake;Urban Community;urban setting;Woman;Work

PROJECT_TITLE: Treating Maternal Depression in an Urban Community-Based Pediatric Asthma Clinic: Targeting Maternal Mood, Child  Asthma Outcomes, and Health Disparities


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: MEMPHIS

ORG_NAME: ST. JUDE CHILDREN'S RESEARCH HOSPITAL

ORG_STATE: TN

PHR: Project Narrative The purpose of this proposal is to develop antibiotics to kill slow-growing biofilm infections that are difficult to treat. To generate antibiotics with this profile, we will conjugate ClpP activators with rifamycin RNA polymerase inhibitors, creating novel dual-targeting antimicrobials.

PI_NAMEs: LAFLEUR, MICHAEL ;LEE, RICHARD E. (contact)

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: acute infection;Affect;analog;Antibiotic Resistance;Antibiotic Therapy;antibiotic tolerance;Antibiotics;antimicrobial;Bacteremia;Bacteria;Binding Proteins;Biochemical;Biological Assay;care costs;Cell Survival;Cells;chronic infection;cytotoxicity;Data;density;Depsipeptides;design;Diabetic Foot Ulcer;DNA-Directed RNA Polymerase;Dose;Drug Kinetics;efficacy evaluation;efficacy study;Ensure;Foreign Bodies;Gene Expression Profiling;Genetic Transcription;Genus Hippocampus;Goals;Growth;Histopathology;Hybrids;improved;In Vitro;in vitro Assay;in vivo;in vivo evaluation;in vivo Model;Individual;Indwelling Catheter;Infection;Infective endocarditis;Interphase Cell;Knowledge;Lead;Lesion;Measures;methicillin resistant Staphylococcus aureus;Microbial Biofilms;Microsomes;Mitochondria;Modeling;Modification;Monitor;Morbidity - disease rate;mortality;mouse model;Multi-Drug Resistance;Mus;New Agents;novel;pathogen;Patient Care;Peptide Hydrolases;Periprosthetic joint infection;persistent bacteria;Pharmaceutical Preparations;pharmacologic;Pharmacology;Pharmacology Study;Phase;Plasma;Plasma Proteins;Population;pre-clinical;prevent;Proteolysis;Proteomics;recurrent infection;Resistance;Resistance development;resistance frequency;resistant strain;Rifabutin;Rifampicin resistance;Rifampin;Rifamycins;RNA;RNA Polymerase Inhibitor;RNA Synthesis Inhibition;Safety;screening;Septicemia;single molecule;Solubility;standard of care;Staphylococcus aureus;Structure;Structure-Activity Relationship;subcutaneous;System;Testing;Thigh structure;tuberculosis treatment;Urea;Vancomycin;Work

PROJECT_TITLE: Hybrid Antibiotics for Persistent Infections

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


NIH_SPENDING_CATS: American Indian or Alaska Native;Asthma;Behavioral and Social Science;Biodefense and Related Countermeasures;Clinical Research;Emerging Infectious Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Lung;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

ORG_CITY: EAGLE BUTTE

ORG_NAME: MISSOURI BREAKS RESEARCH, INC.

ORG_STATE: SD

PHR: The prevalence of asthma among American Indian (AI) children is higher (8.2% as compared to 6.4%) than in non-Hispanic White children, and over 50% of children in the U.S. struggle with uncontrolled asthmatic disease and they also suffer from higher rates of upper and lower respiratory infections as it is sadly demonstrated by the ongoing COVID-19 pandemic. Very little information is available on how Native children are affected by specific viral infection burden and how these immunological factors may be influenced by social and environmental factors (SEF) including adverse childhood events (ACEs), tobacco smoke, and everyday life stressors that may alter immunological state. This community-based study of 550 Tribal children from both urban and rural Reservation areas of South Dakota will target both approaches in order to support culturally appropriate asthma prevention strategies as well as the appropriate local, Tribally-centered family support system in place.

PI_NAMEs: BEST, LYLE G (contact);ERDEI, ESTHER ;TORGERSON, DARA

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: 2019-nCoV;Adult;adverse childhood events;Affect;Age;American Indian community;American Indians;Area;Asthma;asthma prevention;asthmatic;atopy;behavior influence;Biological;Biological Markers;Bronchiolitis;Case/Control Studies;Cheyenne;Child;Childhood Asthma;Cities;Clinical;Clinical Trials;Communities;community advisory board;community engaged research;Complex;COVID-19 pandemic;cytokine;Data;Dedications;design;Development;Disease;Disparity;Education;Emergency department visit;Enrollment;Environmental Risk Factor;Ethnic Population;experience;family support;follow-up;Frequencies;Funding;Gender;Goals;health disparity;Health Policy;High Prevalence;Hospitalization;Household;IgE;Immune;Immune response;Immune system;Immune System Diseases;Immunoglobulin G;Immunoglobulin M;Immunoglobulins;Immunologic Factors;Immunologics;Immunosuppression;Indian reservation;Individual;Industry;Infant;infection burden;Inflammation;Influenza;Influenza A virus;Influenza B Virus;Intervention;Interview;Knowledge;Life;Link;Lower Respiratory Tract Infection;Measurement;Measures;member;minority communities;Missouri;Modification;National Institute on Minority Health and Health Disparities;neglect;Northern Plains;Not Hispanic or Latino;novel strategies;offspring;Outcome;Parents;Participant;pathogen;Pharmaceutical Preparations;Policies;Population;Predisposition;Prevalence;Prevention strategy;Preventive measure;Process;process evaluation;Questionnaires;racial population;Randomized;Recontacts;recruit;referral services;Research;Reservations;respiratory;respiratory health;Respiratory Signs and Symptoms;Respiratory syncytial virus;Respiratory Syncytial Virus Infections;response;Rhinovirus;Risk;Role;Rural;Seasons;Serology;Serum;Severities;Sioux Indians;social;social factors;social influence;social stress;South Dakota;Stress;stressor;Structure;Support System;Surveys;Symptoms;Testing;Teton Sioux Indian;Tobacco smoke;transition to adulthood;tribal community;tribal health;tribal member;Tribes;Upper Respiratory Infections;urban setting;Viral;Viral Respiratory Tract Infection;Virus Diseases;volunteer;Work

PROJECT_TITLE: Factors Influencing Pediatric Asthma into Adulthood (FIPA2)

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dementia;Dissemination and Implementation Research;Health Services;Neurodegenerative;Neurosciences;Palliative Care;Primary Health Care

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PI_NAMEs: KISTLER, CHRISTINE E (contact)

PROGRAM_OFFICER_NAME: FAZIO, ELENA

PROJECT_TERMS: Address;Adoption;Advance Care Planning;Affect;aging related;Algorithms;Alzheimer's Disease;Alzheimer's disease related dementia;American;Cardiology;Caregivers;Caring;case finding;Cessation of life;Characteristics;Clinic;clinical data warehouse;clinical implementation;Clinical Trials;Communication;comparative efficacy;comparison control;comparison intervention;computerized;Consolidated Framework for Implementation Research;Control Groups;Data;decision-making capacity;Dementia;dementia care;design;Diagnosis;Education;efficacy outcomes;efficacy testing;Emergency department visit;empowerment;Ensure;Ethnic Origin;Evaluation;evidence base;Exclusion;experience;Family;Feedback;Future;Goals;health care service utilization;Healthcare;Healthcare Systems;high risk population;hospice environment;Hospitalization;Hour;implementation evaluation;implementation outcomes;improved;Integrated Health Care Systems;Intervention;Interview;Length of Stay;Life;Location;Measures;Medical;Medical Care Team;medical specialties;Medicare;member;Methods;Mission;Modeling;mortality risk;National Institute on Aging;neurodegenerative dementia;Nurses;Nursing Homes;older adult;Oncology;Outcome;Outcome Assessment;Outcome Measure;Outpatients;Palliative Care;Patients;Persons;Physicians;Populations at Risk;portability;Positioning Attribute;preference;Primary Care;primary care clinic;primary care clinician;primary care provider;primary care setting;primary care team;primary outcome;Process;Progressive Disease;Provider;Public Health;Qualitative Methods;Race;Randomized;randomized, clinical trials;Research;Research Design;Sampling;secondary analysis;secondary outcome;skills;skills training;Social Workers;Specific qualifier value;Subgroup;Surveys;Team Nursing;Terminal Disease;Testing;Training and Education;treatment as usual;Treatment Efficacy;trial comparing;United States National Institutes of Health;Variant;Voice;Work

PROJECT_TITLE: Improving Primary Care Clinicians' Advance Care Planning for Alzheimer's Disease and Related Dementias

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Rehabilitation;Racial and Ethnic Minority Health Research;Rehabilitation;Social Determinants of Health

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: PROJECT NARRATIVE Sociodemographic disparities in physical function and use of rehabilitation following total joint arthroplasty have been established, but there is little to no available research regarding approaches to reduce disparities. In the proposed K23 research, we will develop and test implementation of novel post-arthroplasty rehabilitation care pathways designed to maximize function and reduce race and insurance/income disparities in outcomes. Findings from this project will lead to improved quality of rehabilitation and improved equity in outcomes following hip and knee arthroplasty.

PI_NAMEs: BOVE, ALLYN M (contact)

PROGRAM_OFFICER_NAME: SOLIS SANABRIA, CAROLINA VANESSA

PROJECT_TERMS: Acute;Address;Adherence;Administrator;Adoption;Affect;Area;black patient;Black race;Caring;Clinical Practice Guideline;Clinical Services;Collaborations;Communities;Control Groups;Data;Degenerative polyarthritis;design;Development;Disparity;disparity reduction;Effectiveness;effectiveness/implementation trial;Equity;evidence base;Evidence based practice;Focus Groups;Foundations;functional outcomes;Funding;Future;Glean;Goals;Grant;Health;health care disparity;health care settings;health disparity;health equity;Health equity research;Health Sciences;Health Services;Health Services Research;Health system;Hip region structure;hip replacement arthroplasty;Home;Home Health Agency;Hospitalization;Hospitals;Household;implementation science;Improve Access;improved;improved outcome;Income;income disparities;Individual;Insurance;Insurance Coverage;interest;Intervention;Interview;K-Series Research Career Programs;Knee;knee replacement arthroplasty;Knowledge;Low income;Medicaid;Mentored Clinical Scientist Development Program;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methods;Musculoskeletal;National Institute on Minority Health and Health Disparities;novel;Operative Surgical Procedures;Orthopedic Surgery;Outcome;outcome disparities;Outcome Measure;Outpatients;Pain;Pathway interactions;Patient-Focused Outcomes;Patients;Patterns of Care;Phase;Physical Function;Physical therapy;pilot test;Population;Positioning Attribute;Preparation;professor;Provider;Qualitative Research;Quality of Care;Quality of life;Race;racial disparity;Recovery of Function;Rehabilitation Centers;Rehabilitation Outcome;rehabilitation science;rehabilitation service;Rehabilitation therapy;rehabilitative care;Replacement Arthroplasty;Reporting;Research;Research Methodology;Research Personnel;Research Project Grants;Sampling;Schools;Scientist;sociodemographic disparity;Structure;Surgeon;System;systematic review;Testing;Time;Training;United States;Universities;Work

PROJECT_TITLE: Development and Implementation of Optimal Rehabilitation Care Pathways to Reduce Disparities in Rehabilitation Outcomes after Joint Replacement


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Brain Disorders;Genetics;Neurodegenerative;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: PHILADELPHIA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE This proposal seeks to understand pathogenic mechanisms underlying a rare neurodegenerative disorder caused by mutations of SNX13, which encodes a sorting nexin (SNX) protein, that robs children of their motor and cognitive skills. My research will define how this protein and associated biological processes are involved in preserving neuronal function and survival, which could be used to inform the development of more targeted therapeutics for patients.

PI_NAMEs: SANCHEZ, VANESSA BREANNE (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: acid stress;Address;Affect;Ataxia;Behavior;behavior test;Bilateral;Biogenesis;Biological;Biological Process;Brain;career;Cells;Cellular Neurobiology;Cellular Stress;Cerebellar Ataxia;Cerebellar Diseases;Cerebellum;Child;Cholesterol;Cholesterol Homeostasis;cognitive skill;Communication;Confocal Microscopy;CRISPR interference;CRISPR screen;CRISPR/Cas technology;Data;Dependovirus;Development;Disease;DNA Sequence Alteration;Embryo;Endoplasmic Reticulum;Energy Metabolism;excitotoxicity;experience;Fatty Acids;Foundations;Future;genome editing;genome-wide;Goals;Guide RNA;Harvest;Histologic;Homeostasis;human pluripotent stem cell;Image;Impairment;In Situ Hybridization;in vivo;Induced pluripotent stem cell derived human neuron;Injections;insight;knock-down;Leadership;lipid metabolism;Lipids;Mediating;Mentors;Metabolic;Metabolic Diseases;Methodology;Methods;Molecular;Motor;motor behavior;Motor Skills;mouse model;Mus;Mutation;N-Methylaspartate;neonate;Nerve Degeneration;Neurobiology;Neurodegenerative Disorders;Neuroglia;neuron component;Neurons;novel;Oleic Acids;Oxidative Stress;paralogous gene;Pathogenicity;Patients;Pediatric Hospitals;Pennsylvania;Philadelphia;preservation;Production;promoter;protein function;Proteins;Recombinant adeno-associated virus (rAAV);Regulation;Research;Research Personnel;Role;Science;Site;skill acquisition;skills;sorting nexins;Spinocerebellar Ataxias;Stains;stem cell biology;stressor;Structure;System;targeted treatment;Technical Expertise;Techniques;Testing;Training;Transgenic Organisms;translational neuroscience;Triglycerides;Universities;Variant;Visual;Work

PROJECT_TITLE: Investigating SNX13 in Cerebellar Function and Disease


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Physical Injury - Accidents and Adverse Effects;Rural Health;Social Determinants of Health

ORG_CITY: CHAPEL HILL

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Sudden and serious injury is a top cause of death in the United States. The goal of this research is to improve regional trauma systems of care so that underserved rural populations have timely access to life-saving treatment. Analysis of existing data on trauma care and patient mortality and key stakeholder engagement will be integrated to identify strategies to address rural trauma disparities.

PI_NAMEs: PATEL, MEHUL D. (contact)

PROGRAM_OFFICER_NAME: PICHARDO, CATHERINE MELISSA

PROJECT_TERMS: Accident and Emergency department;Acute;acute care;Address;American;Biological Models;care systems;Caring;Cause of Death;Censuses;Cessation of life;Communities;Community Surveys;Complement;Complex;Data;Data Set;demographics;design;Destinations;Development;Disparity;dynamic system;Emergency medical service;Ensure;ethnic minority;Ethnic Origin;experience;Feedback;Goals;Grant;Health care facility;health disparity;Health Services Research;Health system;holistic approach;Hospital Closures;Hospitals;improved;improved outcome;indexing;Information Systems;injured;Injury;Intervention;Left;Life;Link;Medical emergency;member;Methods;model building;Modeling;models and simulation;mortality;National Institute on Minority Health and Health Disparities;North Carolina;novel strategies;patient subsets;Patient-Focused Outcomes;Patients;Persons;Policies;Population;population health;programs;prototype;Provider;Qualitative Methods;Quality of Care;Race;racial minority;Registries;Research;Resources;Rural;rural area;Rural Community;rural disparities;rural dwellers;rural health disparities;Rural Hospitals;Rural Population;rural underserved;rurality;Science;secondary analysis;socioeconomic disadvantage;socioeconomic disparity;socioeconomic diversity;Socioeconomic Status;socioeconomics;Structure;Subgroup;System;Systems Theory;Testing;theories;Time;Trauma;trauma care;trauma centers;Trauma patient;Traumatic injury;Triage;Underinsured;Underserved Population;United States;urban area;years of life lost

PROJECT_TITLE: Regional Trauma Systems of Care to Address Rural Disparities in Injury Mortality

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Data Science;Emerging Infectious Diseases;Immunotherapy;Infectious Diseases;Influenza;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Pneumonia and Influenza

ORG_CITY: MOSCOW

ORG_NAME: UNIVERSITY OF IDAHO

ORG_STATE: ID

PHR: Innate immune manipulation holds enormous promise for reducing the severity of infections and other  human diseases. A new family of computational tools will be developed for predicting the multidimensional  time events of the innate immune that prevent mortality during lethal respiratory viral infections. Without  such a mathematical framework in place, the design of immunotherapies will be slowed, or worse,  dangerous, and faulty.

PI_NAMEs: HERNANDEZ VARGAS, ESTEBAN ABELARDO (contact)

PROGRAM_OFFICER_NAME: YU, GUOQIN

PROJECT_TERMS: 2019-nCoV;Address;Antigen-Antibody Complex;attenuation;Biological;Biological Sciences;biological systems;Biology;Biomedical Research;Cell model;co-infection;Collaborations;complex biological systems;Computational algorithm;computational suite;Computer Models;computerized tools;Computing Methodologies;COVID-19 pandemic;Dangerousness;Data;data integration;design;Differential Equation;Dimensions;Disease;Educational process of instructing;Equation;Equilibrium;Etiology;Europe;Event;experimental study;Family;fictional works;Generations;high dimensionality;high reward;high risk;human disease;Hybrids;Idaho;Immune;Immune response;Immune system;Immune Targeting;Immunologic Factors;immunoregulation;Immunotherapy;improved;Infection;Influenza;influenza infection;Innate Immune System;innovation;Knowledge;Laboratory Finding;large datasets;Machine Learning;machine learning algorithm;machine learning method;mathematical methods;mathematical model;mathematical sciences;Mathematics;Measures;Mediating;Methods;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;novel;pandemic influenza;Parameter Estimation;pathogenic virus;Pathology;Play;predictive modeling;Predictive Value;prevent;Public Health;Public Policy;respiratory;Rhinovirus;Role;Science;Scientist;Severities;Severity of illness;sound;System;Techniques;Testing;theories;Therapeutic;Time;Training;Universities;Viral;Viral Respiratory Tract Infection;Virus;Virus Diseases

PROJECT_TITLE: Novel Hybrid Computational Models to Disentangle Complex Immune Responses


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: NEW YORK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: NEW YORK UNIVERSITY

ORG_STATE: NY

PHR: Narrative This proposal develops a nanoplasmonic-based single-cell imaging technology that enables probing the spatiotemporal profile of protein molecules secreted by individual immune cells. Implementing this technology in studying cellular cytokine secretion behaviors is relevant to the public health because it provides scientific insight into inflammation-related immunology and cell biology governing immune dysregulations and cancer diseases. The technology can be a versatile tool for cellular paracrine/autocrine signaling, cellular immunophenotyping coupled with protein expression profiling, gene expression analysis, molecular-level analysis of infectious diseases, and human leukocyte antigen (HLA) testing.

PI_NAMEs: KURABAYASHI, KATSUO  (contact)

PROJECT_TERMS: Algorithms;aptamer;Area;Autocrine Communication;Behavior;Behavior monitoring;Binding Sites;Biological;Biological Assay;Biomedical Research;Biosensor;cell behavior;Cell Communication;Cell Culture Techniques;Cell Physiology;Cell secretion;Cell surface;cell type;Cells;Cellular biology;cellular imaging;commercialization;communicable disease diagnosis;Communicable Diseases;Communication;cost;Coupled;Coupling;cytokine;Darkness;density;Detection;Development;Disease;Enzyme-Linked Immunosorbent Assay;Expression Profiling;extracellular;fabrication;Fluorescence;Future;Gene Expression Profiling;Hep3B;Human;human leukocyte antigen testing;Image;Imaging Device;Imaging Techniques;Imaging technology;Immune;Immune response;Immune system;Immunity;Immunology;Immunophenotyping;Individual;Inflammation;Inflammatory;insight;intercellular communication;Interleukin-6;Knowledge;Label;Malignant Neoplasms;Marketing;Measures;Mediating;Microfluidics;microscopic imaging;Microscopy;Molecular;nano;nanobiosensor;nanoplasmonic;Nanostructures;novel;paracrine;Pattern;Performance;plasmonics;Population;Primary carcinoma of the liver cells;Process;protein expression;Protein Secretion;Proteins;Public Health;Reagent;real-time images;receptor;Research;Research Personnel;Research Project Grants;Resolution;Sampling;Scientist;secretion process;sensor;Signal Pathway;Signal Transduction;Signal Transduction Pathway;single cell proteins;Spatial Distribution;spatiotemporal;Structure;System;T cell differentiation;T-Cell Activation;T-Lymphocyte;Techniques;Technology;Theoretical model;Time;tool;Visualization;Water

PROJECT_TITLE: Nanoplasmonic Spatiotemporal Imaging of Single-Cell Protein Secretion and Intercellular Communication


FUNDING_MECHANISM: SBIR-STTR RPGS

ORG_CITY: DURHAM

ORG_NAME: AEGISCN, LLC

PHR: Narrative Intracerebral hemorrhage (ICH) is a devastating stroke sub-type with no proven therapy. Based on strong supportive evidence and recent clinical trials, CN-105, a 5-amino acid peptide derived from the receptor binding surface of the apolipoprotein E (apoE), appears to be poised for translation as an acute ICH therapeutic. This project will build on prior our Phase 1 STTR by coupling use of blood proteins and brain imaging to improve patient selection for planning an Phase 3 clinical trial of CN-105 in acute ICH.

PI_NAMEs: BENNETT, ELLEN  (contact)

PROGRAM_OFFICER_NAME: GILCHRIST, FLOY ANNETTE

PROJECT_TERMS: Acute;Age;Algorithms;Amino Acids;anakinra;Anti-Inflammatory Agents;Apolipoprotein E;Binding;Blood Proteins;Brain imaging;CCL2 gene;Cell surface;Cerebral hemisphere hemorrhage;Clinical;clinical efficacy;Clinical Research;clinical translation;Clinical Trials;Cognitive;cohort;Collaborations;comorbidity;Consultations;Coupling;Data;data management;data tools;Death Rate;design;Development;Dose;Drug Kinetics;Edema;Elements;Evolution;excitotoxicity;Face;functional improvement;functional outcomes;Funding;Gelatinase B;glial activation;Half-Life;Histologic;hypertensive;IL17 gene;IL8 gene;improved;Individual;insight;Interleukin-1 beta;Interleukin-10;interleukin-23;Intracranial Hemorrhages;Low-Density Lipoproteins;Manuals;Measurement;Measures;Monitor;neuroinflammation;Neurons;neuroprotection;open label;Orphan Drugs;Outcome;Participant;Patient Selection;Patients;Penetration;Peptides;pharmacologic;Phase;phase I trial;Phase III Clinical Trials;Placebos;pre-clinical;preclinical efficacy;Privatization;Procedures;Proteins;Protocols documentation;Publishing;radiological imaging;Randomized;randomized placebo-controlled clinical trial;rational design;receptor;receptor binding;Recovery;Regimen;Research;Research Institute;response;Safety;safety study;screening;Serology;sex;Singapore;Site;Small Business Technology Transfer Research;Statistical Data Interpretation;Stroke;Supratentorial;Surface;Testing;Therapeutic;Time;translational model;Translations;Treatment Efficacy;treatment response;trial comparing;VWF gene;Work

PROJECT_TITLE: CN-105 Improves Functional Outcome After Intracranial Hemorrhage

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-NV-S(14)B]


ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Project Narrative This proposal will advance our understanding of how the brain changes when someone uses a brain-computer interface for many days, and how brain changes are influenced by the device. Understanding how devices influence the brain is an important step towards building engineering tools that can assure brain-computer interface therapies provide robust performance over time. The outcomes of this proposal have the potential to enable next-generation brain-computer interfaces that can reliably restore movement to paralyzed people for long periods of time across varied tasks.

PI_NAMEs: ORSBORN, AMY L (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TITLE: Optimizing co-adaptation in motor BCIs by uncovering brain-decoder interactions

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Diabetes;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE (PUBLIC HEALTH RELEVANCY STATEMENT) Chinese immigrants suffer a disproportionately high type 2 diabetes (T2D) burden and have poor health outcomes. They face numerous social determinants barriers to accessing evidence-based diabetes programs, including high rates of poverty and limited English proficiency (LEP), and lack of insurance. This project will provide important evidence on scalable strategies to enhance the accessibility of evidence-based diabetes programs in LEP Chinese immigrants with T2D.

PI_NAMEs: HU, LU  (contact)

PROJECT_TERMS: Address;Adherence;arm;Asian;Asian Americans;barrier to care;Behavior;Caring;Certification;Chinese;chronic care model;clinical care;Communities;Community Health Aides;comparison intervention;Control Groups;Counseling;Data;diabetes control;diabetes educator;Diabetes Mellitus;diabetes prevention program;diabetes self-management;Education;effective intervention;efficacy evaluation;evidence base;Evidence based intervention;Evidence based program;Face;Future;Glucose;glycemic control;Glycosylated hemoglobin A;Goals;health disparity;health disparity populations;Health Services Accessibility;Healthy Eating;high risk;Hispanic;Hispanic Populations;Home;Hour;Immigrant;improved;Insurance;Intervention;Knowledge;Limited English Proficiency;Linguistics;Link;Measurement;mHealth;mhealth interventions;Minority Groups;Modeling;National Institute on Minority Health and Health Disparities;New York City;Non-Insulin-Dependent Diabetes Mellitus;Not Hispanic or Latino;novel;Outcome;Participant;Patient-Focused Outcomes;Patients;Persons;Pharmaceutical Preparations;Physical activity;poor health outcome;Population;Population Growth;Poverty;Prediabetes syndrome;primary outcome;programs;Public Health;Randomized;Reporting;Research;Resources;response;secondary outcome;Self Efficacy;skills;social determinants;social health determinants;Subgroup;test strip;Text Messaging;Time;treatment as usual;Uninsured;United States;video delivery;Visit;Waiting Lists;Work

PROJECT_TITLE: LINK-IT: Leveraging vIdeos and commuNity health worKers to address socIal determinants of health in immigranTs


NIH_SPENDING_CATS: Biotechnology;Genetics;Neurosciences

ORG_CITY: BOSTON

ORG_NAME: HARVARD MEDICAL SCHOOL

ORG_STATE: MA

PHR: PROJECT NARRATIVE  The ability of the nervous system to store new information and adapt to new circumstances depends on the plasticity and remodeling of synapses – the fundamental points of communication between nerve cells. Our project is aimed at understanding how the neuron and its partner cell are able to respond to repeated signals by orchestrating a converging set of mechanisms that allow synapse remodeling by tuning the expression of conserved genes that build the underlying structures.

PI_NAMEs: VAN VACTOR, DAVID L. (contact)

PROGRAM_OFFICER_NAME: MILLER, DANIEL L

PROJECT_TERMS: Actins;Acute;Address;Antibodies;Architecture;Binding;Binding Proteins;Binding Sites;Biochemical;Biological;Biological Assay;Biological Process;Cells;Clustered Regularly Interspaced Short Palindromic Repeats;Code;Communication;Complex;conditioned fear;Cues;Cytoskeleton;Data;Dendritic Spines;Dependence;Development;Disease;Drosophila genus;Endocytosis;Excitatory Synapse;Exocytosis;Experimental Genetics;Family;fascinate;fly;gene conservation;Gene Expression;Genes;Genetic;genetic analysis;Genetic Epistasis;genomic tools;Glutamate Receptor;Glutamates;Guanine Nucleotide Exchange Factors;Guanosine Triphosphate Phosphohydrolases;Hippocampus;Human;in vivo evaluation;Link;Logic;Mammals;Mass Spectrum Analysis;Mediating;Membrane;Memory;Messenger RNA;MicroRNAs;Modeling;Molecular;Morphogenesis;Morphology;Motor Neurons;Mus;Muscle;Mutagenesis;N-Methyl-D-Aspartate Receptors;Nature;Nervous System;neural;neural circuit;neuroadaptation;Neurologic;Neuromuscular Junction;Neurons;novel;null mutation;Orthologous Gene;Output;Pathway interactions;Peer Review;Phenotype;Phosphotransferases;postsynaptic;Predictive Factor;Prefrontal Cortex;presynaptic;Process;Property;protein complex;Proteins;Publications;ral Guanine Nucleotide Exchange Factor;recruit;response;Response Elements;Reticulum;Role;screening;sensory input;Sequence Analysis;Signal Transduction;Site-Directed Mutagenesis;Specificity;Structure;Synapses;Synaptic plasticity;Synaptic Transmission;synaptogenesis;System;Testing;Tissues;tool development;trafficking;transgene expression;Translations;Untranslated RNA;Vertebral column;Work

PROJECT_TITLE: microRNA-Regulated Mechanisms Essential for Structural Plasticity of Drosophila Glutamatergic Synapses


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Cerebrovascular;Dementia;Genetics;Hematology;Neurodegenerative;Neurosciences;Rare Diseases;Sickle Cell Disease;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

PHR: Hypoxemia triggers cerebrovascular lesions in the white matter area of the brain associated with cognitive challenges that affect more than half of the patients with sickle cell disease by their adulthood. This project seeks to determine that microvascular hypoxemia induces hypoxia inducible factor-1a which in turn promotes the inhibition of frataxin causing activation of astrocytes, the cells that connect microvessels with the neurons, resulting increased calcium accumulation, neuroaxonal damage and cognitive dysfunction. This project will identify a novel mechanistic pathway that can be targeted for future therapeutics improving cognitive function in SCD.

PI_NAMEs: HAZRA, RIMI  (contact)

PROGRAM_OFFICER_NAME: YIN, XILING

PROJECT_TERMS: Acute;Adult;Affect;age acceleration;age related;Alzheimer's Disease;Anisotropy;Area;Astrocytes;axon injury;Behavioral;Biochemical;Biogenesis;Biological Assay;Blood flow;Blood Vessels;Bone Marrow;Bone Marrow Transplantation;Brain;burden of illness;Calcium;Cells;Cerebral Hypoxia;Cerebral Infarction;Cerebral Ischemia;cerebral microvasculature;cerebrovascular;cerebrovascular lesion;Cerebrovascular system;Cerebrum;Chimera organism;Clinical;Clinical Research;Cognitive;cognitive function;cognitive testing;Data;Development;Diffusion;Diffusion Magnetic Resonance Imaging;Discrimination;Doxorubicin;Event;executive function;Exhibits;experience;experimental study;Exposure to;Foundations;frataxin;Friedreich Ataxia;Functional disorder;Future;Glial Fibrillary Acidic Protein;Health;Hemoglobin;hemoglobin polymer;Hemolysis;Histopathology;Homeostasis;Human;Hypoxemia;Hypoxia;Hypoxia Inducible Factor;Immunofluorescence Immunologic;Impaired cognition;improved;indexing;Individual;Inflammation;Injury;innovation;insight;Iron;Ischemia;Knock-out;Knowledge;Lesion;Link;Magnetic Resonance Imaging;Memory;Mitochondria;Mitochondrial Proteins;mixed dementia;mouse model;Mouse Strains;Mus;Mutate;Myelin Basic Proteins;Nerve Degeneration;Neurofilament-H;Neuroglia;Neurons;neurovascular;new therapeutic target;novel;object recognition;Pathogenesis;Pathway interactions;Patients;Phenocopy;pre-clinical;Prevention;processing speed;Proteins;prototype;Research;resilience;restoration;Role;Short-Term Memory;Sickle Cell Anemia;Sickle Hemoglobin;sickling;Small Interfering RNA;spatial memory;Stains;Stroke;Sulfur;Testing;Therapeutic;therapeutic target;Tissues;transcription factor;Transgenic Organisms;Transplantation;vascular cognitive impairment and dementia;white matter;White Matter Hyperintensity;white matter injury;Wild Type Mouse

PROJECT_TITLE: Neurovascular frataxin and cognitive dysfunction in sickle cell disease

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ED_INST_TYPE: SCHOOLS OF EDUCATION

NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Bioengineering;Brain Disorders;Cerebrovascular;Clinical Research;Neurosciences;Physical Rehabilitation;Rehabilitation;Stroke

ORG_CITY: ATHENS

ORG_DEPT: MISCELLANEOUS

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed project is relevant to public health because it aims to reconceptualize dexterity and identify critical factors in rehabilitation of hand dexterity among stroke survivors by characterizing essential behavioral components and their neuroanatomical substrates, from which a neural mechanistic concept can be built. Upon successful completion, a new model of hand dexterity and a sound rationale for developing effective therapeutic interventions will emerge, which will facilitate reacquisition of dexterity and optimization of hand function recovery. Thus, the proposed research is relevant to the part of the NIH’s mission that pertains to the application of the scientific and clinical knowledge gained from this project to enhance health and reduce disability.

PI_NAMEs: XU, JING  (contact)

PROGRAM_OFFICER_NAME: DOPERALSKI, ADELE ELIZABETH

PROJECT_TERMS: 3-Dimensional;Behavior;behavior measurement;Behavioral;Behavioral Mechanisms;Behavioral Paradigm;Biological Markers;Biomechanics;chronic stroke;Clinical;Clinical assessments;Corticospinal Tracts;Data;design;Devices;dexterity;Diffusion Magnetic Resonance Imaging;disability;Disease;Fingers;flexibility;Goals;grasp;H-Reflex;Hand;hand dysfunction;Hand functions;hand rehabilitation;Hand Strength;Health;Human;Human Activities;Impairment;improved;indexing;Individuation;innovation;Interneurons;Isometric Exercise;kinematics;Kinetics;Knowledge;Maps;Measures;Mediating;Methods;Mission;Modeling;Movement;neural;neural circuit;neural model;Neural Pathways;neural stimulation;Neuroanatomy;Neurobiology;neuromechanism;neurophysiology;novel;optimal treatments;Paresis;Pathway interactions;Patients;Peripheral Nerve Stimulation;Play;post stroke;predictive modeling;prognostic;Proxy;Public Health;Quality of life;Recovery;Reflex action;Rehabilitation therapy;Reporting;Research;Resolution;reticulospinal tract;Role;sensor;Severities;sound;Spinal;strength training;Stroke;stroke patient;stroke rehabilitation;stroke survivor;Structure;targeted treatment;Techniques;Testing;Therapeutic Intervention;therapeutically effective;therapy design;Time;tractography;Training;Transcranial magnetic stimulation;United States National Institutes of Health;Upper Extremity;Work

PROJECT_TITLE: Dissecting Behavioral and Neural Mechanisms of Hand Dexterity after Stroke for Effective Rehabilitation

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Antimicrobial Resistance;Infectious Diseases;Malaria;Orphan Drug;Rare Diseases;Vector-Borne Diseases

ORG_NAME: REACTIVE BIOSCIENCES INC

PHR: PROJECT NARRATIVE New drugs to treat malaria are urgently needed; this project is a Phase II SBIR drug discovery collaboration between Reactive Biosciences and UCSF to discover and develop new antimalarial medicines. This program will include the lead optimization of promising boron-containing antimalarials identified in Phase I, evaluation of drug-like properties of these compounds, mechanism of action studies, profiling of activity in animal models, and safety. Ultimately, these studies will lead to the identification of a candidate compound for development as a new drug to treat and prevent malaria.

PI_NAMEs: BAKER, STEVE  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Address;Africa;Ames Assay;Animal Model;Anti-malarials;Artemisinins;asexual;Biological;Biological Assay;Biological Availability;Biological Sciences;Blood;Boron;Canis familiaris;Cessation of life;Chemical Structure;Chemicals;Chemistry;Chemoprotection;Child;Collaborations;commercialization;Computational Technique;Data;design;Development;Dose;drug candidate;drug discovery;Drug Evaluation;Drug Interactions;Drug Kinetics;Drug resistance;Drug Targeting;Erythrocytes;Exhibits;experience;Goals;Human;humanized mouse;improved;In Vitro;in vitro activity;in vivo;Infection;Knowledge;Lead;lead optimization;Malaria;Malaria prevention;Maximum Tolerated Dose;Medicine;member;Micronucleus Tests;Modeling;mouse model;Mus;novel;novel therapeutics;Oral;Parasite resistance;Parasitemia;Parasites;Parasitic Diseases;Parents;Pharmaceutical Chemistry;Pharmaceutical Preparations;pharmacologic;Phase;Phosphotransferases;Plasmodium falciparum;preclinical development;Pregnant Women;prevent;programs;Property;rational design;Rattus;Resistance;resistance mechanism;resistant strain;Route;Safety;safety assessment;safety study;scaffold;scale up;Series;Small Business Innovation Research Grant;Southeastern Asia;Specificity;Structure-Activity Relationship;Toxic effect;Toxicology;whole genome

PROJECT_TITLE: Boron-containing antimalarial drug discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-DCAI-F(12)]


NIH_SPENDING_CATS: Bioengineering;Microbiome

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: We will develop tools for interactome analysis in microbial communities with the long-run goal of defining  principles behind community behavior and responses to invasion. This project will generate a multi-omics  map of the THOR community's response to invasion and concepts that support inference of pathways  underlying emergent phenotypes. This will establish the foundation for reasoning about community  interactions, a prerequisite for engineering microbial systems for human and environmental health.

PI_NAMEs: HANDELSMAN, JO E.;SANKARAN, KRIS  (contact)

PROJECT_TERMS: 16S ribosomal RNA sequencing;Address;Automobile Driving;Behavior;Binding;Biological Assay;Communities;Complex;Computer software;Data;data curation;Data Sources;design;Disease;Engineering;Environmental Health;Event;Exhibits;experience;Experimental Designs;experimental study;Foundations;Functional disorder;Goals;Human;improved;innovation;Internet;Intervention;Invaded;Knock-out;Laboratory Study;Maps;metabolomics;metatranscriptomics;Methods;microbial;microbial community;microorganism;Modeling;Molecular Profiling;multiple omics;National Institute of General Medical Sciences;Nature;Pathway Analysis;Pathway interactions;Phenotype;Population Dynamics;Proxy;Pseudomonas aeruginosa;Quality Control;response;Running;Shapes;Statistical Methods;success;System;Testing;tool

PROJECT_TITLE: DMS/NIGMS 1: Modeling Microbial Community Response to Invasion: A Multi-Omics and Multifacton


NIH_SPENDING_CATS: Behavioral and Social Science;Firearms Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Physical Activity;Physical Injury - Accidents and Adverse Effects;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Research

ORG_CITY: SYRACUSE

ORG_NAME: SYRACUSE UNIVERSITY

PHR: PROJECT NARRATIVE Black Americans are disproportionately impacted by firearm violence. The goal of the proposed project is to determine how residential segregation, vacant and abandoned properties, neighborhood walkability, and green space access combine in unique ways to create neighborhood profiles that differentially expose Black Americans to gun violence. This effort will inform policy and prevention strategies that more effectively reduce Black Americans’ firearm violence exposure by targeting the unique patterns of place-based features defining those neighborhoods conferring the greatest exposure risk.

PI_NAMEs: HRUSKA, BRYCE J (contact)

PROJECT_TERMS: Address;Admission activity;Area;assault;Black American;caucasian American;Censuses;Cities;Classification;Communities;Country;Crime;Data;Data Analyses;Dimensions;Disparity;experience;Feeling;Firearms;Fostering;Fright;Future;Goals;Green space;Gun injury;gun violence;Health;health disparity populations;Hospitals;Hour;innovation;insight;interest;Joints;Knowledge;large scale data;Link;Medical center;National Institute on Minority Health and Health Disparities;neighborhood safety;Neighborhoods;New York;novel strategies;Pattern;Personal Satisfaction;Persons;Physical environment;Policies;Population;Positioning Attribute;Prevention strategy;Property;Public Health;Research;residential segregation;Risk;social culture;Source;statistics;success;Techniques;Translating;United States;Universities;urban setting;Violence;violence exposure;walkability

PROJECT_TITLE: Examining Neighborhood Profiles Defined by Place-Based Community Features and their Relationships with Firearm Violence Disparities


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Physical Injury - Accidents and Adverse Effects;Post-Traumatic Stress Disorder (PTSD);Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Violence Against Women;Violence Research;Women's Health Research

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Pre- and post-migration exposures to traumatic life experiences are associated with significant negative impact on health and well-being of immigrant women. This study will build evidence for a digital intervention to improve health and safety outcomes of immigrant women with lifetime exposures to violence.

PI_NAMEs: SABRI, BUSHRA  (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: 18 year old;acceptability and feasibility;Address;African;arm;Asian;Black race;care systems;Caring;Cellular Phone;Charge;Child Abuse;cognitive interview;Complex;Conflict (Psychology);Congo;coping;Country;depressive symptoms;design;digital;digital intervention;Economics;effective intervention;Effectiveness;efficacy evaluation;efficacy testing;Eligibility Determination;empowerment;ethnic minority population;Evaluation;evidence base;Exposure to;Family Violence;Feedback;follow-up;Forcible intercourse;Future;gender-based violence;Guatemala;Health;health disparity;health inequalities;Health Professional;Health Promotion;Health Services Accessibility;help-seeking behavior;high risk;Hispanic;HIV/STD;Household;Hydrocortisone;Immigrant;Immigration;improved;improved outcome;Internet;Interpersonal Violence;Intervention;intervention delivery;intervention effect;intimate partner violence;Knowledge;Latino;Life;Life Experience;life span;longitudinal design;marginalization;Measures;Mediator;Mental Health;Methods;migration;mindfulness-based stress reduction;mobile phone based intervention;Modeling;Modification;multi-component intervention;novel;Outcome;Outcome Assessment;Participant;Patient Self-Report;perpetrators;Personal Satisfaction;Phase;physical conditioning;Physiological Processes;Pilot Projects;pilot trial;Politics;Population;Post-Traumatic Stress Disorders;prevent;protective factors;Protocols documentation;psychoeducation;psychologic;racial health disparity;racial minority population;Randomized;Randomized, Controlled Trials;Reduce health disparities;resilience;Resources;Risk;Safety;safety outcomes;Self Care;Self Efficacy;service providers;Service setting;Severities;Shame;skills;social culture;Social support;Somalia;standard care;Stress;stress reactivity;stress reduction;stressor;Survivors;Symptoms;Technology;Telephone;Testing;Time;Transportation;Trauma;treatment arm;trial design;underserved area;Underserved Population;United States National Institutes of Health;user-friendly;Violence;violence exposure;War;Woman;Women's Group;Women's Health;women's outcomes

PROJECT_TITLE: Being Safe, Healthy and Positively Empowered (BSHAPE): A Technology-Based Multicomponent Intervention to Improve Outcomes for Immigrant Women with Cumulative Exposures to Violence

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ED_INST_TYPE: OVERALL MEDICAL

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: Project Narrative We discovered that genetically modified cytomegalovirus (CMV) can elicit T cells that recognize non-self peptides presented by Major Histocompatibility-E (MHC-E) molecules, including peptides derived from foreign antigens inserted into CMV, and that these T cells protect against simian immunodeficiency virus suggesting that prophylactic HIV vaccines that elicit MHC-E-restricted T cells might similarly achieve protection. While peptide presentation by classical MHC-I molecules is well understood, very little is known about how MHC-E presents non-self peptides because MHC-E generally presents a self-peptide contained within classical MHC-I proteins to natural killer cells as a self-protective mechanism and to better understand why CMV is the only known vaccine platform capable of eliciting MHC-E-restricted CD8+ T cell responses to any antigen, we will study the molecular antigen-presenting mechanisms that enable CMV to elicit these responses and how these T cells recognize HIV-infected cells. 1

PI_NAMEs: FRUH, KLAUS J (contact);SACHA, JONAH B.

PROGRAM_OFFICER_NAME: GAUTAM, RAJEEV

PROJECT_TERMS: AIDS vaccine development;Antibodies;Antigen Presentation;Antigen Presentation Pathway;antigen processing;Antigens;Bacteria;Binding;Biology;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;CD94 Antigen;Cell Line;cell type;Cells;cellular targeting;Clinical;Complex;CRISPR screen;Cytomegalovirus;Cytoprotection;Data;design;Endoplasmic Reticulum;Epitopes;experience;Frequencies;Gene Deletion;Gene Expression;Gene Expression Profile;Gene Modified;Gene Targeting;Genes;genetic testing;Goals;Heterophile Antigens;Histocompatibility;Histocompatibility Antigens Class II;HIV;HIV vaccine;Human;Image;Immune response;Immunity;immunodeficiency;Immunologics;Immunology;Immunotherapeutic agent;In Vitro;in vivo;Infection;Integration Host Factors;International;Lentivirus;Macaca mulatta;Mediating;MicroRNAs;Modeling;Molecular;Monitor;monocyte;Mycobacterium tuberculosis;Myelogenous;Myeloid Cells;N-terminal;Natural Killer Cells;novel;novel vaccines;Outcome;Parasites;Pathogenicity;Pathway interactions;Peptides;Phase;Plasmodium knowlesi;posters;prophylactic;Protein Sortings;Proteins;Reagent;Recombinants;Research;Research Personnel;response;Rhesus;Role;seropositive;Signal Transduction;Site;SIV;small hairpin RNA;Sorting;Structure;Surface;T cell differentiation;T cell response;T memory cell;T-Cell Receptor;T-Lymphocyte;Techniques;trafficking;transcriptomics;translational immunology;Translations;Vaccine Design;vaccine platform;Vaccines;vector;vector vaccine;Vesicle;Viral;Viral Genes;Viral Proteins;Virulent;Virus;Work

PROJECT_TITLE: Non-canonical epitope presentation and antigen processing by MHC-E

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Adolescent Sexual Activity;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Social Determinants of Health

ORG_NAME: CHILDREN'S RESEARCH INSTITUTE

PHR: PROJECT NARRATIVE This project addresses the interdisciplinary care and self-advocacy needs of youth with variations in sex traits (VST), also known as differences of sex development or Intersex. By purposively recruiting a diverse sample of youth and emerging adults with VST in a community participatory process, and developing, calibrating, and validating a self-advocacy tool for youth with VST, this psychometric initiative will provide young people greater voice in their interdisciplinary VST care—care which often involves irreversible medical decision-making during childhood and adolescence with life-long ramifications for gender-related well-being, sexual and urological function, and psychosocial health. The resulting measure will also identify and characterize VST health-related distress to inform attuned and personalized interdisciplinary clinical care practices, and will examine VST intragroup disparities to inform more equitable interdisciplinary care models.

PI_NAMEs: CRERAND, CANICE ELLEN;STRANG, JOHN  (contact);TISHELMAN, AMY C

PROGRAM_OFFICER_NAME: POPKIN, RONNA

PROJECT_TERMS: Address;Adolescence;Adult;Advocacy;Advocate;Age;Anatomy;Body Image;Calibration;care preference;care providers;Caring;Childhood;Clinic;Clinical;clinical care;clinical decision-making;Clinical Research;cognitive interview;Collaborations;Communication;Communities;Complex;Comprehension;coping;Decision Making;design;Development;Disparity;Disparity population;Distress;emerging adult;emerging adulthood;Ensure;Equity;ethnoracial;Exhibits;experience;Exposure to;Face;Factor Analysis;Fertility;follow-up;Functional disorder;Funding;Gender;Gender Identity;gender minority;gender minority health disparity;Genetic;Genitalia;Genitourinary system;Geography;Goals;Health;health disparity;health disparity populations;Health Services Accessibility;Healthcare;Impairment;Individual;intersectionality;Intersex;Interview;Lived experience;marginalization;Measurement;Measures;Medical;Mental Health;Methods;Minority;Modeling;National Institute of Child Health and Human Development;National Institute on Minority Health and Health Disparities;neglect;Neurodevelopmental Disability;Operative Surgical Procedures;Parents;patient engagement;Patient Self-Report;Personal Satisfaction;personalized care;Persons;Phenotypic Sex;Pilot Projects;preference;Procedures;Process;prototype;Provider;psychologic;psychological trauma;Psychometrics;psychosocial;Psychosocial Assessment and Care;Quality of life;Recommendation;recruit;Reporting;Research;research and development;response;Risk;Sampling;Science;sex;sex development disorder;sex linked trait;Sexual Development;shared decision making;social stigma;standard of care;Standardization;Structure;Subgroup;Testing;tool;Torture;traumatic stress;United Nations;United States National Institutes of Health;urologic;Validation;Validity and Reliability;Variant;Voice;Youth

PROJECT_TITLE: Equitable Measurement of Care Disparities and Needs in Intersex Youth/Youth with Variations in Sex Development

STUDY_SECTION: ICSC

STUDY_SECTION_NAME: Interdisciplinary Clinical Care in Specialty Care Settings Study Section[ICSC]


NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Endometriosis;Pain Research;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Women's Health Research

ORG_CITY: CHICAGO

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

PHR: NARRATIVE Endometriosis is a disease that promotes infertility and pain in reproductive-aged women and it remains unclear why only some women develop endometriosis. We propose that underlying genetics contribute to the pathophysiology of endometriosis. We have made for the first time, new model systems including induced pluripotent stem cells from women with endometriosis as well as a new microfluidic device in order to study the pathogenesis of endometriosis.

PI_NAMEs: KIM, JI-YONG JULIE (contact)

PROGRAM_OFFICER_NAME: TINGEN, CANDACE M

PROJECT_TERMS: Affect;Age;aged;Area;Behavior;Biological Assay;Biological Models;Blood Cells;cell bank;Cell Line;Cell Physiology;Cells;chronic pelvic pain;Clinic;Communities;Control Groups;differentiation protocol;Disease;DNA analysis;Endometrial;endometrial organoid;endometriosis;Epithelial Cells;Etiology;Event;experience;Functional disorder;Gene Expression;Genetic;genetic variant;genome wide association study;girls;Gynecologic;Hand;Immune;Immune System Diseases;In Vitro;Individual;induced pluripotent stem cell;Infertility;Inherited;innovative technologies;insight;Macrophage;Mesothelium;Microfluidic Microchips;microfluidic technology;Microfluidics;microphysiology system;Molecular;monocyte;novel;novel strategies;Organ;Ovarian hormone;Ovary;Pain;Pathogenesis;Pathologic;Peripheral Blood Mononuclear Cell;Phenotype;Physiological;Polycystic Ovary Syndrome;Population;Property;Protocols documentation;reproductive;Research;Research Personnel;Resources;Retrograde Menstruation;Stromal Cells;System;Technology;technology platform;Time;tissue/cell culture;Tissues;tool;transcriptome sequencing;Uterus;Variant;Woman

PROJECT_TITLE: Microphysiological modeling of Endometriosis


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Dementia;Frontotemporal Dementia (FTD);Neurodegenerative;Neurosciences

ORG_CITY: DALLAS

ORG_NAME: UT SOUTHWESTERN MEDICAL CENTER

PHR: PROJECT NARRATIVE Through continued practice, skilled behaviors can become rote and maintained throughout life with seemingly minimal effort. Nonetheless, disruptions to skilled behaviors can be early indicators or diagnostic of neurodegenerative diseases. The goal of this research program is to identify the cellular and synaptic mechanisms for maintaining skilled behaviors and tracking how the brain changes as previously learned behaviors begin to decrystallize.

PI_NAMEs: ROBERTS, TODD F (contact)

PROJECT_TERMS: Adult;Area;Attention;Basal Ganglia;Behavior;bird song;Birds;Brain;Childhood;cohort;Corpus striatum structure;Deterioration;Diagnostic;Dopamine;Evaluation;Fiber;frontotemporal degeneration;Functional Imaging;Funding;Goals;hearing impairment;Image;insight;Language;learned behavior;Learning;Life;Longevity;Maintenance;Maps;mature animal;Midbrain structure;Modeling;Monitor;Motor;Neurodegenerative Disorders;Neurons;novel;Opsin;Optics;optogenetics;Output;Parkinson Disease;Pathway interactions;Pattern;Performance;Photometry;Presynaptic Terminals;Primary Progressive Aphasia;Process;Production;programs;Prosencephalon;Psychological reinforcement;Research;Rewards;Role;Signal Transduction;single nucleus RNA-sequencing;skills;Songbirds;Specificity;Speech;Stereotyping;Synapses;syntax;Testing;Thalamic structure;Time;Update;Ventral Tegmental Area;vocal learning;vocalization;zebra finch

PROJECT_TITLE: Reinforcement Mechanisms for Learning Vocal Behaviors - Renewal - 1

STUDY_SECTION: NMB

STUDY_SECTION_NAME: Neurobiology of Motivated Behavior Study Section[NMB]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Infectious Diseases;Microbiome

ORG_CITY: Aurora

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Bacteriophage resistance imposes severe fitness defects on bacteria. Using enterococci which are intestinal commensals and established opportunistic pathogens, we will study phage resistance in these bacteria that leads to heightened antibiotic sensitivity and intestinal colonization defects. With this knowledge we can develop phages as precision therapeutics that target drug resistant enterococci that reside in the intestine.

PI_NAMEs: DUERKOP, BRECK A (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Active Sites;Address;Adherence;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Antigens;Automobile Driving;Bacteria;Bacterial Antibiotic Resistance;bacterial fitness;Bacterial Infections;Bacteriophages;beta-Lactams;Biogenesis;Biological Products;Cell surface;Cell Wall;clinically relevant;Combined Antibiotics;Combined Modality Therapy;cost;Daptomycin;Defect;Development;Drug resistance;Drug Targeting;Emergency Situation;Enterococcus;Enterococcus faecalis;Enterococcus faecium;fitness;Genes;Gram-Positive Bacteria;gut colonization;Health;Hospitals;Human;Hydrolase;immune clearance;Infection;Intestines;Knowledge;Measures;Mediating;Mediator;microbiota;model organism;mutant;Mutation;N-Acetylmuramoyl-L-alanine Amidase;Nosocomial Infections;novel;novel strategies;novel therapeutic intervention;novel therapeutics;opportunistic pathogen;Outcome;pathogen;pathogenic bacteria;Penicillin-Binding Proteins;Peptidoglycan;Phenotype;Polysaccharides;Population;Precision therapeutics;Predatory Behavior;pressure;Public Health;Resistance;Resistance development;resistant strain;Shapes;Surface;Therapeutic;Traction;Vancomycin;Vancomycin resistant enterococcus;Variant;Virulence;Virus;Work

PROJECT_TITLE: Mechanistic basis of bacteriophages for the decolonization of vancomycin resistant enterococci in the intestine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIRT-J(01)]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease;Bioengineering;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Machine Learning and Artificial Intelligence;Patient Safety;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Rheumatoid Arthritis

ORG_CITY: MINNEAPOLIS

ORG_DEPT: SURGERY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Fully utilizing the genetic, clinical and survey data in the All of Us program, we will develop the risk modeling pipeline with integrated genetic-clinical-social risk factors and composite onset-timing outcomes. We will further develop privacy preserving external validation and transfer learning strategy to facilitate demonstration and application of All of Us modeling. Our methods will be showcased in risk modeling for rheumatoid arthritis and cancer cardiotoxicity with validation on external healthcare data at Mass-General-Brigham and M Health Fairview.

PI_NAMEs: HOU, JUE ;WANG, JINHUA ;ZHANG, RUI  (contact)

PROGRAM_OFFICER_NAME: BICKHAM-WRIGHT, UTIBE RONALD

PROJECT_TERMS: Accounting;Address;Algorithms;All of Us Research Program;Cardiotoxicity;Caring;case-based;Clinical;Clinical Data;Code;cohort;Communication;Computer software;Data;Data Analyses;data exchange;data harmonization;design;Development;Diagnosis;economic disparity;Electronic Health Record;empowerment;Engineering;Ethnic Origin;Ethnic Population;evidence base;feature selection;Genetic;Genetic Heterogeneity;genetic information;Genetic Risk;genetic risk factor;genome sequencing;genome wide association study;Goals;Guide prevention;Health;health equity;Healthcare;Healthcare Systems;Heterogeneity;improved;Individual;innovation;Intervention;Learning;learning strategy;Link;Malignant Breast Neoplasm;Malignant Neoplasms;Medical Genetics;Methods;Mining;Minority;Minority Groups;Minority Participation;Modeling;multimodal data;multimodality;Onset of illness;open source;Outcome;overtreatment;Patient Outcomes Assessments;patient population;Patient risk;Patients;Pattern;Performance;point of care;Population;precision medicine;predictive tools;privacy preservation;Race;racial population;Reporting;Research;Research Design;Research Project Grants;Resolution;Rheumatoid Arthritis;Risk;Risk Estimate;Risk Factors;risk prediction;risk prediction model;risk stratification;Sample Size;social;social health determinants;Source;statistics;Surveys;Toes;tool;Training;trait;transfer learning;Validation;whole genome

PROJECT_TITLE: Mining minority enriched AllofUs data for innovative ethnic specific risk prediction modeling


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Biomedical Imaging;Cancer;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: HANOVER

ORG_NAME: GRANITE MEDICAL, LLC

ORG_STATE: NH

PHR: PROJECT NARRATIVE This project is the development of a non-invasively extending distal femur replacement for children and adolescents undergoing bone tumor resection for maintaining limb length equality. Each year in the US there are 200-250 malignant bone tumor diagnoses in the distal femurs of patients 15 years and younger. Our device is simple, robust, MRI compatible, can be extended more gradually at home, has far more extension capability and is designed for a reduced complication rate when compared to its sole US competitor.

PI_NAMEs: GORDON, JEFFREY DAVID (contact)

PROGRAM_OFFICER_NAME: WANG, XIBIN


ORG_NAME: DANA-FARBER CANCER INST

PHR: PROJECT NARRATIVE Inhibition of macrophages is an essential step in resolving acute inflammation. A cellular metabolite known as itaconate was shown to be the major inhibitor of macrophage activation but the exact mechanism by which itaconate exerts this function remains unclear. Here, we will test if a newfound target of itaconate, a protein called SHP-1, is responsible for itaconate inhibition of macrophage activity.

PI_NAMEs: CHOUCHANI, EDWARD THOMAS (contact)

PROGRAM_OFFICER_NAME: VAZQUEZ-MALDONADO, NANCY

PROJECT_TERMS: Aconitic Acid;Acute;Anti-Inflammatory Agents;Antiinflammatory Effect;Binding;Biochemistry;Biological;Biological Assay;Biology;Carboxy-Lyases;Cell Physiology;Cells;Chemicals;Chronic;Citric Acid Cycle;CRISPR/Cas technology;Crystallography;Cysteine;cytokine;cytotoxic;Data;Development;Electron Transport;Genetic;Human;IL18 gene;immune activation;Immunity;Impairment;improved;Inflammasome;Inflammation;Inflammatory;inhibitor;innate immune function;interest;Interferon Type I;Interleukin-6;IRAK1 gene;Laboratories;Lead;Libraries;Literature;loss of function;Macrophage;Macrophage Activation;MAPK8 gene;Maps;Mediating;Methods;mimetics;Modeling;Modification;Mus;Neutrophil Activation;NF-kappa B;novel;NR0B2 gene;p38 Mitogen Activated Protein Kinase;Pathology;Peptides;Pharmaceutical Chemistry;Pharmaceutical Preparations;Phenocopy;Phenotype;prevent;Process;Production;Protein Tyrosine Phosphatase;Proteins;Proteome;Regulation;Research;response;Role;scaffold;Shunt Device;Site;small molecule;Specificity;src Homology Region 2 Domain;STAT3 gene;Stimulus;Structure;Succinate Dehydrogenase;Testing;Time;tool;translational potential

PROJECT_TITLE: Targeting SHP-1 through a newfound metabolite-regulated cysteine activation site

STUDY_SECTION_NAME: Chemical Biology and Probes Study Section[CBP]


NIH_SPENDING_CATS: Bioengineering;Infectious Diseases;Networking and Information Technology R&D (NITRD)

ORG_CITY: BLACKSBURG

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

ORG_STATE: VA

PHR: Synergy across scientific fields is necessary in order to advance understanding, predicting, and responding  to pathogen emergence and spread. Our cross-disciplinary approach will leverage mathematical  techniques and empirical data by investigating infectious disease transmission at multiple biological scales,  with the aim of improving predictions and aiding recommendations for optimal interventions.

PI_NAMEs: CIUPE, STANCA M. (contact)

PROJECT_TERMS: 2019-nCoV;age related;Animals;Biological;Birds;Case Study;Cessation of life;Collaborations;Collection;Communicable Diseases;Couples;Culicidae;curriculum development;Data;Data Collection;data exchange;Data Set;Databases;Development;Disease;Disease Outbreaks;Disease Progression;disease transmission;Education;Educational workshop;Epidemiology;Experimental Designs;Frequencies;Goals;Grant;Health;Human;Immune system;Immunologic Markers;improved;Incidence;Individual;Infection;infection rate;Infectious Agent;infectious disease model;influenza infection;Interdisciplinary Study;interest;Intervention;Investigation;junior high school;Length;Link;mathematical methods;mathematical model;Mathematics;Measurement;Methods;model development;Modeling;multi-scale modeling;multidisciplinary;National Institute of General Medical Sciences;Noise;outcome prediction;outreach;Parameter Estimation;pathogen;Pathogenesis;Pharmacologic Substance;Play;Policies;Population;predictive modeling;Probability;Process;programs;protein biomarkers;Public Health;Quarantine;Recommendation;recruit;Reporting;Reproducibility;Reproducibility of Results;Research;response;Role;Sample Size;Selection Bias;Series;Societies;Source;Specific qualifier value;Statistical Models;student training;Students;synergism;System;Techniques;Testing;Time;transmission process;Uncertainty;undergraduate student;vector;vector mosquito;vector transmission;Viral;Viral Load result;Viral Markers;Virus;Virus Diseases;wild bird;Work

PROJECT_TITLE: Collaborative Research: DMS/NIGMS 1: Identifiability investigation of Multi-scale Models of Infectious Diseases


ED_INST_TYPE: EARTH SCIENCES/RESOURCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Genetics;Mental Health;Mental Illness

ORG_CITY: CHAMPAIGN

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

ORG_STATE: IL

PHR: PROJECT NARRATIVE  Foxes bred for tameness, unlike their wild ancestors, respond in a positive, friendly manner towards humans, similar to domesticated dogs, who, unlike their wolf ancestors, are friendly to people. This project studies the genetics of these inherited fox behaviors in order to understand the causes and mechanisms involved and to potentially gain broader insight into a range of human neurological disorders that are characterized by impaired social reciprocity or by anxiety-related and/or aggressive behaviors.

PI_NAMEs: KUKEKOVA, ANNA  (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Academy;Aggressive behavior;Animal Model;Anxiety;anxiety-like behavior;Behavior;Behavioral;behavioral phenotyping;Breeding;Canis familiaris;Complex;Cytology;Development;Disease;disorder risk;Exhibits;foxes;Friends;General Population;Genes;Genetic;genetic information;Genetic study;Goals;Growth;Human;Impairment;Inherited;insight;Mental disorders;Molecular;Nervous System Disorder;novel;Pathway interactions;Persons;Phenotype;Population;Rodent;Science;segregation;Severities;Social Behavior;Social Behavior Disorders;Social Facilitation;social influence;social reciprocity;Symptoms;Variant;Vulpes;wolves

PROJECT_TITLE: Molecular Mechanisms of Social Behavior

STUDY_SECTION: MRAA

STUDY_SECTION_NAME: Maximizing Investigators? Research Award A Study Section[MRAA]


NIH_SPENDING_CATS: Genetics

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF HOUSTON

ORG_STATE: TX

PHR: Project narrative  RNA editing of transposable elements within cellular RNAs by the ADAR1 enzyme helps the cell distinguish between self and non-self RNAs. The Z-RNA binding domain of ADAR1 plays a role in that process, which remains uncharacterized. Our goal is to structurally, dynamically and geographically (across transcriptomes) characterize the formation of Z-RNA and their recognition by ADAR1, with repercussions on better understanding cancer and certain auto- immune diseases.

PI_NAMEs: VICENS, QUENTIN  (contact);VOGELI, BEAT ROLF

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Address;Adenosine;Adopted;Adoption;Affect;Alu Elements;Autoimmune;Autoimmune Diseases;Base Sequence;Binding;Binding Sites;Biological Process;Biophysics;Brain Diseases;Cells;Contracts;Cytoplasm;Cytosine;Disease;DNA Transposable Elements;dsRNA adenosine deaminase;Enzymes;Event;Gene Expression Regulation;Geography;Goals;Guanosine;Human;Immune response;Immune system;in vivo;Infection;Infectious Agent;Innate Immune Response;Inosine;Interferons;Joints;Knowledge;Lead;Left;Malignant Neoplasms;Mediating;Methods;Molecular Conformation;molecular recognition;mutant;Names;Nervous System Disorder;next generation sequencing;Nuclear;plasma protein Z;Play;Point Mutation;Population;Prevalence;Process;Protein Isoforms;Proteins;pseudotoxoplasmosis syndrome;Publishing;Regulation;response;restraint;RNA;RNA Conformation;RNA Editing;RNA Recognition Motif;RNA Viruses;Role;Sampling;Site;Specificity;Structure;Techniques;three dimensional structure;transcriptome;transcriptome sequencing;tumor;tumor progression;Work;Z-Form DNA

PROJECT_TITLE: Molecular recognition by ADAR1 of Z-RNA within transcriptomes

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cannabinoid Research;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse

ORG_CITY: OMAHA

ORG_NAME: UNIVERSITY OF NEBRASKA MEDICAL CENTER

ORG_STATE: NE

PHR: Project Narrative This will be the first intergenerational study to assess racial disparities in the influence of parental marijuana use on youth marijuana and other substance drug use in African Americans and Hispanics/Latinos, two NIH- designated health disparity populations. We will further assess the effects of marijuana legalization and other determinants on intergenerational drug use behaviors by racial and ethnic groups. This mixed-methods sequential explanatory study will be pursued by integrating analyses of intergenerational and longitudinal surveys and semi-structured interviews

PI_NAMEs: DAI, HONGYING DAISY (contact)

PROGRAM_OFFICER_NAME: HUELSNITZ, CHLOE OLIVIA

PROJECT_TERMS: 18 year old;acute stress;Adolescence;Adolescent;adolescent offspring;adolescent substance use;Adult;African American;African American population;Age;Behavior;Brain;Cannabis policy;Child;Chronic stress;Communities;Complement;Counseling;Data;Databases;Development;Discrimination;Disparity;Drug usage;drug use behavior;Environment;Ethnic Origin;Ethnic Population;Etiology;experience;Exposure to;Family;Fathers;Future;Goals;Growth;Health;health data;health disparity populations;High School Student;Hispanic Populations;Household;illicit drug use;Individual;innovation;Institution;intergenerational;Intervention;Interview;Latino Population;Legal;Legal Status;Link;Longitudinal Surveys;low socioeconomic status;Marijuana;marijuana legalization;marijuana use;marijuana user;Mediating;Mediation;Mental Health;Methods;Modeling;Mothers;Not Hispanic or Latino;offspring;Outcome;outcome disparities;parental influence;Parents;peer;Perception;Pharmaceutical Preparations;Policies;Population Assessment of Tobacco and Health;Prevalence;prevent;prospective;protective factors;psychological distress;Psychological Stress;Race;racial disparity;racial minority;racial population;racism;Reduce health disparities;Regression Analysis;Reporting;Risk;Risk Factors;screening;sex;Social Change;social disparities;social norm;Social status;Socioeconomic Status;Stress;Structure;Substance abuse problem;substance use;Surveys;Testing;Tobacco;transmission process;United States;United States National Institutes of Health;vaping;Youth

PROJECT_TITLE: Racial disparities for the effects of parental marijuana use on youth marijuana and other substance use

STUDY_SECTION: PDRP

STUDY_SECTION_NAME: Psychosocial Development, Risk and Prevention Study Section[PDRP]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Health Services;Neurodegenerative

ORG_CITY: INDIANAPOLIS

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Project Narrative-Relevance of research to public health. Nursing homes (NHs) continue to be a critical component of the U.S. system of post-acute and long-term care for people with multiple chronic conditions (MCCs), Alzheimer’s disease and related dementias (ADRD), serious illness, and functional impairment, yet numerous challenges remain to achieving consistent quality care that optimizes resident outcomes. There is widespread, long standing consensus that NHs are a challenging setting for research. The NEXT STEPs (Nursing Home EXplanatory Clinical Trials: Supporting Transformation by Enhancing Partnerships) Network creates a national infrastructure that will address systemic barriers to conducting research in NHs.

PI_NAMEs: UNROE, KATHLEEN T (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: Active Learning;Acute;Address;Advocacy;Alzheimer's disease related dementia;Behavioral;care delivery;Caring;Clinical;clinical practice;Clinical Research;Clinical Trials;Clinical Trials Design;Clinical Trials Network;Collaborations;Collection;Communities;community engagement;Complex;Conduct Clinical Trials;Consensus;Consent;Consultations;Data;Data Collection;data integration;Data Set;data sharing;dementia care;design;Development;Diagnostic tests;Discipline;Educational workshop;Electronic Health Record;Elements;Ensure;Environment;Equity;Ethics;evidence base;Exclusion;experience;experimental study;Family;Fostering;Friends;Frontline worker;Functional impairment;Funding;Goals;Grant;health care settings;Health Services;High Prevalence;Home Nursing Care;improved;Industry;Infrastructure;innovation;interest;Investments;Knowledge;Leadership;Learning;Link;Long-Term Care;loved ones;Marketing;Measures;Medical;Medicare claim;meetings;Mentorship;Methods;Modeling;multiple chronic conditions;Nursing Homes;organizational structure;Outcome;Pathway interactions;Persons;Pilot Projects;Population;Prevention;Procedures;Process;programs;Public Health;Published Comment;Qualifying;Quality of Care;Quality of life;Records;recruit;Regulation;Research;Research Infrastructure;Research Personnel;Research Priority;service intervention;Site;Special Population;Structure;symposium;System;systemic barrier;Therapeutic;therapy design;tool;Training;Translational Research;trial design;United States National Institutes of Health;Vulnerable Populations;Work

PROJECT_TITLE: The NH Explanatory Trials Network: Supporting Transformation by Enhancing Partnerships (The NEXT STEPS).

STUDY_SECTION_NAME: Special Emphasis Panel[ZAG1 ZIJ-5 (M2)]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Dental, Oral, and Craniofacial Disease;Down Syndrome;Infectious Diseases;Intellectual and Developmental Disabilities (IDD);Neurodegenerative;Neurosciences

PHR: NARRATIVE The proposed studies will investigate the association of chronic periodontitis with the hallmark pathologic features of Alzheimer’s Disease in individuals with Down Syndrome. More specifically, we will address the role of a new class of dihydroceramide lipids, named phosphoglycerol dihydroceramide (PGDHC), produced by the key periodontal pathogen Porphyromonas gingivalis in sex-associated pathogenic amyloidogenesis of amyloid precursor protein using mouse models of Down syndrome.

PI_NAMEs: MOVILA, ALEXANDRU  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: abeta accumulation;Abeta synthesis;Administrative Supplement;age related;aging population;alpha-glycerophosphoric acid;Alzheimer's Disease;Alzheimer's disease brain;Amyloid;Amyloid beta-42;Amyloid beta-Protein Precursor;amyloid pathology;amyloid precursor protein processing;amyloidogenesis;Area;Autopsy;Bacteria;Basic Science;bone loss;Brain;Chromosome 21;Circulation;Data;digital;dihydroceramide;Down's Syndrome;dysbiosis;Experimental Models;Foundations;Funding;Future;high reward;high risk;Independent Scientist Award;Individual;Inflammatory;Knowledge;Lipids;Mediating;Molecular;mouse model;mouse Ts65Dn;Mus;Names;novel;Oral;Oral Pathology;Osteolysis;overexpression;Parents;Pathogenicity;Pathologic;Patients;Peptides;Periodontitis;periodontopathogen;Persons;Porphyromonas gingivalis;Proteolysis;Reporting;Research Personnel;response;Role;sex;Testing;Trisomy;United States National Institutes of Health;Virulent;Wild Type Mouse

PROJECT_TITLE: Roles of Periodontal Bacteria-Derived Dihydroceramides in Alzheimer's Disease Exacerbated by Down Syndrome


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Cancer

ORG_CITY: STATESBORO

ORG_NAME: GEORGIA SOUTHERN UNIVERSITY

PHR: Public Health Relevance Statement. More than 90% of cancer deaths are associated to metastasis, a number that is upwards of 500,000 in 2023. This project contributes to the development of migrastatics, drugs that specifically act by inhibiting invasion and metastasis, contributing to improving patient outcomes particularly of late-stage/metastatic cancers.

PI_NAMEs: DELA CERNA, MARK VINCENT CARREON (contact)

PROGRAM_OFFICER_NAME: BERNAL, FEDERICO

PROJECT_TERMS: Acceleration;Address;Affinity;Anchorage-Independent Growth;Area;Award;Binding;Biological Assay;Biological Markers;Biological Process;Biomedical Research;Cancer Model;Cancer Patient;cancer therapy;Catalogs;Cessation of life;Chemicals;Colorectal Cancer;colorectal cancer metastasis;Complex;Cytoskeleton;Data;Development;Disseminated Malignant Neoplasm;Drug Design;drug discovery;early-career faculty;epithelial to mesenchymal transition;Exhibits;experimental study;falls;Family;Fluorescence;Funding;Goals;Hypoxia;improved;improved outcome;In Vitro;inhibitor;interest;Invaded;Libraries;Life;Link;Malignant Neoplasms;member;Molecular;Molecular Mechanisms of Action;Molecular Target;mortality;Neoplasm Metastasis;novel;Oncogenic;Oncology;Pathway interactions;Patient Care;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;phosphatase of regenerating liver;Phosphoric Monoester Hydrolases;Population;prevent;Primary Neoplasm;Process;public health relevance;rational design;Regulation;Research;Role;screening;Site;small molecule;Specificity;Structure;Structure-Activity Relationship;Students;success;targeted treatment;tool;Universities

PROJECT_TITLE: PRL3 inhibitors as migrastatics and the molecular determinants of PRL3 druggability

STUDY_SECTION_NAME: Special Emphasis Panel[ZGM1 RCB-7 (SF)]


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

ORG_CITY: SAN MARCOS

ORG_NAME: TEXAS STATE UNIVERSITY

PHR: PROJECT NARRATIVE The goal of the Texas Doctoral Bridge Program, a formal partnership between Hispanic Serving Institutions Texas State University (master's degree granting institution) and the University of Texas Health Science Center at San Antonio (UTHSA) (Ph.D. granting institution), is to increase the number of students from historically marginalized groups (HMGs) who complete doctoral studies in the biomedical sciences. There is an urgent need to strengthen and diversify the biomedical research workforce to address disparities linked to race/ethnicity and socio-economic status amongst other factors. Through a series of programmatic activities involving rigorous didactic preparation and integrated research training, M.S. students from HMGs at Texas State will be bridged into competitive Ph.D. programs at UTHSA or other first-rate biomedical institutions.

PI_NAMEs: LEWIS, KAREN ADELL;LIBICH, DAVID STEVEN;OYAJOBI, BABATUNDE OLUKAYODE;WHITTEN, STEVEN T (contact)

PROGRAM_OFFICER_NAME: BLATCH, SYDELLA ANNE

PROJECT_TERMS: bridge program;Texas

PROJECT_TITLE: Texas Doctoral Bridge Program

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Assistive Technology;Bioengineering;Clinical Research;Disability Research;Hearing Loss;Neurosciences;Prevention;Rehabilitation

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: CREIGHTON UNIVERSITY

PHR: NARRATIVE  Graduate trainees with hearing loss or other diverse backgrounds will be recruited to participate in research rotations in auditory and vestibular neuroscience research laboratories of the Bellucci Translational Hearing Center at Creighton University prior to selecting their doctoral thesis advisors within the Department of Biomedical Sciences. While working with Internal and External Mentors, including those with hearing loss or other diverse backgrounds, all R25 trainees and alumni will develop the capacity, resilience, and preferred career trajectories to become research leaders in science, technology, engineering, mathematics, and medicine (STEMM), preferably in NIDCD mission areas.

PI_NAMEs: STEYGER, PETER STEPHEN (contact)

PROGRAM_OFFICER_NAME: RIVERA-RENTAS, ALBERTO L

PROJECT_TERMS: Academia;Academic achievement;Acceleration;Affect;Age;age related;Aging;American;American Speech-Language-Hearing Association;Area;Auditory;Award;Bachelor's Degree;career;Clinical;Cochlear Implants;cohort;college;Communities;Data;deaf;digital;Doctor of Philosophy;Doctor's Degree;Early Diagnosis;Education Projects;education research;effective intervention;Engineering;Ethnic Origin;Etiology;experience;Faculty;Feedback;Funding;General Population;Genus Mentha;Goals;graduate student;hard of hearing;Hearing;Hearing Aids;hearing impairment;hearing preservation;hearing restoration;improved;Individual;infancy;insight;Institution;Journals;Laboratory Research;Language;Leadership;Mainstreaming;Manuscripts;meetings;Mentors;Minor;Mission;National Institute on Deafness and Other Communication Disorders;Neurosciences;Neurosciences Research;next generation;Noise;novel strategies;novel therapeutic intervention;Otolaryngology;Outcome;peer networks;Performance;Persons;Pharmaceutical Preparations;Postdoctoral Fellow;preservation;Productivity;programs;Qualifying;recruit;Research;resilience;Resources;Rotation;Schools;Science;science, technology, engineering, mathematics, and medicine;Scientist;Sensory;Sensory disabilities;Series;Site;skills;Societies;socioeconomics;Speech;Students;Sum;symposium;Syndrome;Training;training opportunity;Training Programs;Travel;undergraduate student;United States National Institutes of Health;Universities;Vestibular function;vestibular system;Work

PROJECT_TITLE: Enhancing Diverse Graduate Student Opportunities in Auditory and Vestibular Neuroscience

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-Z (43)]