ADMINISTERING_IC: LM

IC_NAME: NATIONAL LIBRARY OF MEDICINE

NIH_SPENDING_CATS: Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: TALLAHASSEE

ORG_NAME: INSILICOM, LLC

PHR: Project narrative This application aims to apply an award-winning pipeline to construct the largest-scale knowledge graph (KG) to date using all PubMed abstracts and PubMed Central full-text articles. Applications that are previously infeasible will then be developed on top of the KG including KG-based knowledge visualization, knowledge navigation and knowledge discovery. As our model is able to distinguish between new discoveries and background knowledge in scientific articles, we will also develop novel tools taking advantages of this new capability.

PI_NAMEs: ZHANG, JINFENG  (contact)

PROGRAM_OFFICER_NAME: FARRELL, CATHERINE MARY

PROJECT_TERMS: Acceleration;Address;Adverse effects;Area;Award;Biological;biomedical scientist;Cell Line;cell type;COVID-19;Creativeness;Data;Data Set;deep learning;deep learning model;Deposition;Development;Disease;drug repurposing;graph knowledge base;Homo sapiens;improved;information framework;Information Retrieval;innovation;interest;Knowledge;Knowledge Discovery;knowledge graph;knowledge integration;Link;Literature;Manuals;Methodology;Methods;Modeling;Modernization;Names;National Center for Advancing Translational Sciences;Natural Language Processing;novel;Organ;Patients;Probability;Process;Publications;Publishing;PubMed;Reading;remdesivir;Research;Research Personnel;Resources;Rewards;Science;search engine;Speed;Structure;System;Text;text searching;Time;Tissues;tool;trend;United States National Aeronautics and Space Administration;United States National Institutes of Health;Visualization;Visualization software;wasting

PROJECT_TITLE: Constructing a large-scale biomedical knowledge graph using all PubMed abstracts and PMC full-text articles and its applications

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]


ADMINISTERING_IC: HL

ARRA_FUNDED: N

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Obstructive Pulmonary Disease;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Dissemination and Implementation Research;Health Services;Lung;Rehabilitation;Telehealth

ORG_CITY: SPRINGFIELD

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BAYSTATE MEDICAL CENTER, INC.

ORG_STATE: MA

PHR: PROJECT NARRATIVE Chronic Obstructive Pulmonary Disease (COPD) affects approximately 16 million Americans, and is characterized by recurrent exacerbations that lead to 1.5 million Emergency Department visits and 700,000 hospitalizations annually. Pulmonary rehabilitation (PR) is a structured program of exercise and self- management support that has been proven to relieve shortness of breath and increase quality of life when initiated after an exacerbation, but unfortunately, few eligible patients participate. This project will compare the effectiveness of two novel strategies – one involving video narratives of other patients telling their story of how they overcame challenges and completed PR, the other involving telephonic peer coaching – to enhanced usual care, and to each other, at increasing patient participation in PR after an exacerbation.

PI_NAMEs: LINDENAUER, PETER KYLE (contact)

PROGRAM_OFFICER_NAME: ROPER, REBECCA

PROJECT_TERMS: acute care;Adopted;Adult;Advisory Committees;Affect;American;arm;Attitude;Behavior;behavior change;Belief;blood pressure control;Chronic Disease;Chronic Obstructive Pulmonary Disease;Clinical;clinical outcome assessment;cohort;compare effectiveness;Consent;cost;deconditioning;Development;diabetes self-management;Disease Management;Dyspnea;Effectiveness;effectiveness evaluation;effectiveness/implementation trial;Eligibility Determination;Emergency department visit;Europe;exercise program;Expectancy;Goals;group intervention;Guidelines;Health;health literacy;health related quality of life;Health system;hospital readmission;Hospitalization;Hospitals;implementation outcomes;implementation strategy;improved;Individual;Infrastructure;Intervention;intervention effect;intervention refinement;Interview;Knowledge;Lead;Leadership;Libraries;Lived experience;Mediating;Methods;Modeling;mortality;motivational enhancement therapy;Narration;National Heart, Lung, and Blood Institute;novel strategies;Outcome;Patient Participation;Patients;peer;peer coaching;peer support;Phase;Physicians;Policies;prevent;Procedures;Professional Organizations;programs;Protocols documentation;pulmonary rehabilitation;Quality of life;Randomized;Recommendation;Recovery;recruit;Recurrence;Research;Self Efficacy;Self Management;Shortness of Breath;Social support;Structure;Surveys;Techniques;Telephone;Testing;Training;Transportation;treatment as usual;United States;uptake;Visit

PROJECT_TITLE: Improving Participation in Pulmonary Rehabilitation through Peer-Support and Storytelling


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Brain Disorders;Drug Abuse (NIDA only);Neurosciences;Substance Misuse

ORG_CITY: NEW YORK

ORG_DEPT: NEUROSCIENCES

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

ORG_STATE: NY

PHR: Project Narrative Research regarding the dopaminergic system, which is highly involved in reward, voluntary motor behavior, and substance use disorders, has long focused on neurons. With evidence that microglia can modulate neuronal activity and the discovery of a novel subpopulation of microglia expressing the dopamine receptor DRD1 by our lab, support for a glial axis of dopaminergic regulation is mounting. In this proposal, I will use transgenic mouse models to investigate the determinants of microglial DRD1 expression and how it impacts the neuronal response in two instances of sustained changes in dopamine levels: juvenile dopaminergic development and chronic cocaine.

PI_NAMEs: HAYS, EMMA  (contact)

PROGRAM_OFFICER_NAME: FALCON-MORALES, EDGARDO

PROJECT_TERMS: Ablation;Adolescent;Adult;Attention deficit hyperactivity disorder;Behavior;behavioral response;Brain;Brain region;Cells;Central Nervous System;Characteristics;Chronic;Cocaine;Corpus striatum structure;Cues;Data;Development;Disease;Dopamine;Dopamine D1 Receptor;Dopamine Receptor;dopamine transporter;dopaminergic neuron;Dorsal;DRD1 gene;Drug usage;effective therapy;Electrophysiology (science);Embryonic Development;Environment;Event;Exhibits;experimental study;Fire - disasters;FOS gene;Functional disorder;Gene Expression;Gene Expression Profile;Genetic;Growth;Heterogeneity;hindbrain;Human;Immediate-Early Genes;Immune;immune function;In Situ Hybridization;Induced Neurons;Invaded;Investigation;Level of Evidence;Link;Literature;Macrophage;Maintenance;Measures;Mediating;Mental Depression;Microglia;Motivation;motor behavior;mouse model;Mus;Nervous System Disorder;Neurodegenerative Disorders;neuronal excitability;Neurons;Neuropeptides;neuropsychiatric disorder;Neurotransmitters;new therapeutic target;novel;Parkinson Disease;patch clamp;Phenotype;Physiological;Play;postnatal development;prenatal;receptor;receptor expression;recruit;Regulation;Reporting;Research;response;reuptake;Rewards;Role;Signal Transduction;Stains;Substance Use Disorder;System;Techniques;Time;Tissues;Transcript;Transgenic Mice;Transplantation;Wild Type Mouse

PROJECT_TITLE: Microglia-neuron dopamine signaling - a novel mechanism of dopamine circuit modulation

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F03A-E(20)]


ADMINISTERING_IC: AA

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Clinical Research;Prevention;Social Determinants of Health;Substance Misuse;Substance Misuse Prevention

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

PHR: PROJECT NARRATIVE Research on the impact of alcohol outlet density on alcohol consumption has recently remained stalled due to the mixed results of ecological and individual-level studies, in addition to the lack of clarity regarding the threshold effects of every additional alcohol outlet added to an area. We propose to create a responsive buffer — a new measurement of individuals’ exposure to the alcohol environment that is responsive to documented individual-level and neighborhood-level characteristics — to advance studies on alcohol outlet density. A new measurement of the alcohol environment has critical implications for establishment of the relationship of alcohol outlet density and alcohol consumption, which will therefore directly inform environmental prevention efforts, like licensing and zoning, to reduce alcohol consumption and improve population health.

PI_NAMEs: MEHRANBOD, CHRISTINA AREZOU (contact)

PROGRAM_OFFICER_NAME: PARASURAMAN, SARIKA RANE

PROJECT_TERMS: Acute;Address;Advocacy;Advocate;Affect;alcohol availability;Alcohol consumption;alcohol effect;alcohol epidemiology;alcohol exposure;alcohol measurement;alcohol misuse;alcohol outlet density;alcohol prevention;alcohol research;Alcoholic Beverages;Alcohols;Area;Buffers;Censuses;Characteristics;Chronic;Consensus;Consumption;cost;Country;Data;density;distilled alcoholic beverage;doctoral student;drinking;Economics;Effectiveness;Environment;evidence base;experience;Failure;Fellowship;Funding;Health;Healthcare;improved;Individual;Injury;innovation;International Agencies;Intervention;Licensing;Liver diseases;Location;Malignant Neoplasms;Measurement;Measures;Mentorship;Methodology;Methods;Mission;Modeling;Modification;National Institute on Alcohol Abuse and Alcoholism;Nature;Neighborhoods;novel;Pattern;Personal Satisfaction;Persons;Policies;Population;population health;preventable death;Prevention;Prevention strategy;Productivity;Public Health;Publications;Publishing;Regulation;Research;research and development;Research Personnel;research study;Research Technics;residence;Restaurants;Risk Factors;Science;spatial epidemiology;structured data;systematic review;theories;Training;Translating;Translations;Travel;Uncertainty;United States;United States National Institutes of Health;Update;Violence;Work;Workplace

PROJECT_TITLE: Examining Individuals' Exposure to Alcohol Environments Using Novel Responsive Buffers


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ANN ARBOR

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE In the retina, opsin molecules that capture light are housed within disc-shaped membranes stacked in the outer segment compartment of photoreceptor neurons. Many inherited retinal diseases are caused by defects in formation of the disc membranes within the outer segment, leading to photoreceptor cell death and human blindness. The purpose of this proposal is to investigate components that contribute to forming these disc membranes to better understand the pathogenesis of inherited retinal degeneration and identify potential treatment targets.

PI_NAMEs: NAYLOR, MOLLY  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Ablation;absorption;Acceleration;Actins;Address;Affect;Alternative Splicing;Architecture;Automobile Driving;base;Blindness;Cell Death;Cell membrane;Cell Physiology;Cellular biology;Cilia;cyclic-nucleotide gated ion channels;Data;Defect;depolymerization;Diameter;Disease;Distal;Electric Stimulation;Event;Exons;experimental study;Future;Genes;Genetic;Glutamic Acid;Goals;Growth;Health;Human;Impairment;in vivo;Inherited;inherited retinal degeneration;insight;Investigation;Kinetics;Knock-out;Knockout Mice;Knowledge;Lead;Length;Life;Light;Maintenance;Measures;Membrane;Modeling;Molecular;Morphogenesis;mouse model;Mus;Mutation;Neurons;novel;Opsin;Organelles;Pathogenesis;Phagocytosis;Photoreceptors;Phototoxicity;Physiologic pulse;Play;Process;programs;Proteins;Radiolabeled;recruit;Regulation;Reporter;Research;Retina;Retinal Degeneration;Retinal Diseases;retinal rods;Rod;rod outer segment disc;Role;Seminal;Shapes;Signal Transduction;Structure of retinal pigment epithelium;Surface;Tertiary Protein Structure;Testing;tool;trafficking;Vision;vision science;Visualization;Wild Type Mouse

PROJECT_TITLE: Understanding the Role of GARP Proteins in Rod Outer Segment Disc Formation and Retinal Degeneration


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Aging;Cancer;Cancer Genomics;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: Project Narrative This project will construct, evaluate polygenic risk scores (PRS), and estimate absolute and excess relative risk of cancer jointly for PRS and established risk factors in multiethnic populations from six large-scale, longstanding cohorts. This research will inform the development and implementation of risk models across populations to better guide public health screening and potentially inform clinicians and patients in treatment decisions.

PI_NAMEs: CONTI, DAVID V (contact);WITTE, JOHN S.

PROGRAM_OFFICER_NAME: CAGA-ANAN, EMILIE CHARLISSE F

PROJECT_TERMS: Address;Admixture;African American;African American population;age group;age related;Aging;analysis pipeline;Area;Asian;Cancer Burden;cancer epidemiology;cancer risk;Case/Control Studies;Characteristics;Clinical;cohort;Cohort Analysis;Computer software;Data;data resource;Data Set;Development;disorder risk;Disparity;Environmental Risk Factor;epidemiology study;ethnic difference;Ethnic Origin;Ethnic Population;European ancestry;Evaluation;Evaluation Methodology;experience;Follow-Up Studies;Genetic;genetic association;Genetic Research;genetic resource;Genetic Risk;genome wide association study;genome-wide;Genomic medicine;Health;health disparity;Health Professional;high risk;High-Risk Cancer;Human;improved;Incidence;Individual;Inherited;Japanese;Joints;Latino Population;Linkage Disequilibrium;Malignant neoplasm of liver;Malignant neoplasm of prostate;Malignant Neoplasms;Measures;men;Methods;Modeling;mortality;multi-ethnic;novel;Nurses' Health Study;Odds Ratio;Outcome;Pacific Islander;Patients;Performance;Phenotype;polygenic risk score;Population;Population Heterogeneity;Predictive Value;Predisposition;Probability;Prospective cohort;Prospective, cohort study;Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial;Public Health;Race;racial difference;racial diversity;racial population;Relative Risks;Reproducibility;Research;Research Design;Resources;Risk;Risk Estimate;Risk Factors;risk prediction;risk variant;ROC Curve;screening;Signal Transduction;Site;social factors;software development;Specificity;Statistical Methods;statistics;Testing;trait;translational potential;Translations;Variant;Woman;Women's Health

PROJECT_TITLE: Leveraging Diversity in Cancer Epidemiology Cohorts and Novel Methods to Improve Polygenic Risk Scores


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Coronaviruses;Emerging Infectious Diseases;Genetics;Immunization;Infectious Diseases;Vaccine Related

ORG_CITY: STANFORD

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE RNA molecules play fundamental roles in transmitting and regulating genetic information in all living systems, including disease-causing bacteria, RNA viruses like HIV and SARS-CoV-2, tumor cells, and our own brains and bodies. New potentially life-saving therapies and vaccines that target or repurpose these RNAs are being hindered by our imperfect understanding of how RNAs fold into intricate 3D structures. Our work aims to develop new 3D-structure-focused tools that are missing in current RNA biomedical research.

PI_NAMEs: DAS, RHIJU  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: 2019-nCoV;Acceleration;Address;Anti-Bacterial Agents;Antisense Oligonucleotides;Bacteria;Biochemical;Biomedical Research;biophysical model;Biophysics;Brain;Complex;COVID-19;COVID-19 pandemic;crowdsourcing;Crystallography;design;Development;Disabling;Disease;Electron Microscopy;experimental study;flexibility;Foundations;genetic information;Genome;HIV;human disease;Hybrids;In Vitro;Life;Machine Learning;Messenger RNA;Methods;Modeling;Molecular Conformation;neoplastic cell;novel;Organism;pandemic disease;Phylogenetic Analysis;Play;Research;RNA;RNA Computations;RNA Folding;RNA vaccine;RNA Viruses;Role;Science;Shipping;Structure;Syringes;therapeutic genome editing;three dimensional structure;tool;transmission process;tumor;Untranslated RNA;Vaccines;Viral;Virus Replication;Visualization;Work

PROJECT_TITLE: Modeling and design of complex RNA structures

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]


NIH_SPENDING_CATS: Infectious Diseases;Lung;Stem Cell Research;Stem Cell Research - Nonembryonic - Human

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

PHR: The microfold cell (M cell) is known to be a central actor in regulating mucosal inflammation in barrier organs but has received almost no attention in the lung. We now show that lung M cells can be induced by airway inflammation and by viral infection. We seek to define the functional roles of these understudied cells in the setting of lung inflammation and infection so that we can lay a foundation for designing new therapies targeting inflammatory and infectious diseases of the lung.

PI_NAMEs: RAJAGOPAL, JAYARAJ  (contact)

PROGRAM_OFFICER_NAME: ESPINOZA GRANDON, INGRID CECILIA

PROJECT_TERMS: Ablation;airway epithelium;airway inflammation;Antigen Presentation;Antigens;Applications Grants;Attention;B-Lymphocytes;Biology;Bronchus-Associated Lymphoid Tissue;Cell Communication;Cell Culture Techniques;Cell Differentiation process;Cell Lineage;Cell Physiology;cell type;Cells;chemokine;cytokine;Data;Data Set;Dendritic Cells;design;Developmental Biology;directed differentiation;Disease;disease model;Epithelial Cells;Epithelium;Event;Foundations;Gastrointestinal tract structure;Gene Modified;Genetic;Human;imaging platform;Immune;immunohistochemical markers;Immunologics;Infectious Lung Disorder;Inflammation;Inflammatory;inflammatory lung disease;Influenza;influenza infection;Label;Lipopolysaccharides;Literature;Lung;Lung infections;Lymphoid Follicle;M cell;Maintenance;Modeling;Molecular;mouse model;Mucosal Immunity;Mucositis;Mucous Membrane;Mus;Neuroendocrine Cell;new therapeutic target;novel;Organ;pathogen;pharmacologic;Photons;Physiological;progenitor;pulmonary function;Pulmonary Inflammation;Reagent;Reporting;Role;Sampling;Signal Pathway;Signal Transduction;Slice;SOX8 gene;stem cell biology;stem cells;Stimulus;Testing;Time;TNFSF11 gene;tool;Trachea;transcriptome;transcytosis;Viral;Virus Diseases

PROJECT_TITLE: Progenitors, Mechanisms of Differentiation, and Functions of Lung M Cells

STUDY_SECTION: LIRR

STUDY_SECTION_NAME: Lung Injury, Repair, and Remodeling Study Section[LIRR]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Aging;Brain Disorders;Clinical Research;Down Syndrome;Genetics;Immunization;Intellectual and Developmental Disabilities (IDD);Vaccine Related

ORG_CITY: SEATTLE

ORG_NAME: BENAROYA RESEARCH INST AT VIRGINIA MASON

ORG_STATE: WA

PHR: Project Narrative The proposed research is relevant to public health because it interrogates how immune aging impairs functional response to vaccination and how dysregulation of CD4+ T cells drives advanced immune aging, leveraging Down syndrome as a genetic model. This knowledge would establish the foundation to identify the patients, both with and without Down syndrome, who would benefit from altered vaccination strategies, and novel therapeutics to attenuate advanced immune aging, with likely utility across a broad spectrum of immune- related conditions. Thus, the proposed research is relevant to the part of NIH’s mission pertaining to reducing illness and disability.

PI_NAMEs: KHOR, BERNARD  (contact)

PROGRAM_OFFICER_NAME: PRABHUDAS, MERCY R

PROJECT_TERMS: Address;Affect;Age;Age of Onset;Aging;aging population;Architecture;Attenuated;Autoantigens;Autoimmune;Autoimmune Diseases;Autoimmunity;biobank;Biochemical;Birth;Cardiovascular Diseases;CD4 Positive T Lymphocytes;Cells;Cellular biology;Childhood;Chromosome 21;Chromosome abnormality;Clinical;cohort;Coupled;COVID-19;cytokine;Data;Defect;Diabetes Mellitus;disability;Disease;Dissection;Down's Syndrome;effective therapy;Elderly;Epigenetic Process;Exhibits;experimental study;Foundations;Functional impairment;Future;General Population;Generations;Genes;Genetic;Genetic Models;Genetic Transcription;Goals;Growth;Health;Human;Immune;immune function;immune health;Immune response;Immune system;Immune System Diseases;immunosenescence;Impairment;in vitro Assay;in vivo;Individual;Infection;Inflammaging;Inflammatory;innovation;insight;Insulin-Dependent Diabetes Mellitus;Investigation;Knowledge;Longitudinal cohort;Longitudinal Studies;Malignant Neoplasms;Manuscripts;Methods;Mission;mosaic;novel;novel therapeutic intervention;novel therapeutics;Outcome;Participant;pathological aging;Pathway interactions;Patients;Persons;Phenotype;Predisposition;prevent;Public Health;Publishing;Reporting;Research;response;Risk;Role;T-Lymphocyte;Testing;Therapeutic;transcriptome sequencing;United States National Institutes of Health;Vaccination;vaccination strategy;vaccine immunogenicity;vaccine response;Work

PROJECT_TITLE: Mechanistic and functional dissection of inflammaging in Down syndrome

STUDY_SECTION: CMIB

STUDY_SECTION_NAME: Cellular and Molecular Immunology - B Study Section[CMIB]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

ORG_CITY: PASADENA

ORG_NAME: CALIFORNIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE Chediak-Higashi Syndrome (CHS) patients show enlarged lysosome-related organelles (LROs) resulting from either excessive fusion or inhibited fission of vesicles together with defects in microtubule and centrosome behavior at the immunological synapse. LRO biogenesis is highly conserved in Drosophila, allowing us to exploit its genetic and molecular cell biological advantages to study both vesicle trafficking and microtubule and centrosome behavior in the oocyte and embryo. This will illuminate the controversial role of the protein encoded by the gene mutated in CHS not only in the LRO, but importantly also in centrosome and microtubule behavior and will thereby unlock possibilities for developing drugs to treat CHS patients.

PI_NAMEs: GLOVER, DAVID M (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Affect;Antigen-Presenting Cells;Behavior;Biogenesis;Biological;Blastoderm;Blood Platelets;Cell Nucleus;cell type;Cells;Centrosome;chediak-higashi syndrome;CHS1 gene;Co-Immunoprecipitations;Coma;Complex;Cytoplasm;Cytoplasmic Granules;Cytotoxic T-Lymphocytes;Defect;Development;Dissociation;Dominant-Negative Mutation;Drosophila genus;dynactin;Dynein ATPase;Embryo;Enabling Factors;Endosomes;Failure;Female;Film;gamma Tubulin;gene product;Genes;Genetic;Human;immunological synapse;Immunologics;Immunoprecipitation;In Vitro;Knowledge;lysosomal proteins;Lysosomes;Lytic;Mass Spectrum Analysis;Mediating;Melanosomes;Microtubule-Associated Proteins;Microtubules;Mitosis;Modeling;Molecular;Mothers;mutant;Mutate;Mutation;Oocytes;Organelles;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Pilot Projects;Polyploidy;Positioning Attribute;Process;protein transport;Proteins;recruit;Regulatory Pathway;Reporting;Research;Resolution;Role;SNAP receptor;System;Testing;therapeutic development;trafficking;Translating;Vesicle

PROJECT_TITLE: Common Regulatory Pathways for the Genesis of Lysosome-Related Organelles and Dynamics of Microtubules during Development

STUDY_SECTION_NAME: Development - 1 Study Section[DEV1]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Hematology;Infectious Diseases;Malaria;Orphan Drug;Patient Safety;Pediatric;Rare Diseases;Sickle Cell Disease;Vector-Borne Diseases

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: PROJECT NARRATIVE Sickle cell anemia is an inherited blood disorder with enormous global burden of disease, especially within sub-Saharan Africa, where it causes severe morbidity and high early mortality. We are conducting a large research study (REACH) for children with sickle cell anemia living in four African countries to test the safety, feasibility, and benefits of hydroxyurea treatment in this setting, and to better understand the scientific and genetic reasons why children respond differently to hydroxyurea treatment. We will now investigate the long-term benefits of hydroxyurea treatment as these children enter puberty, focusing on prevention of organ damage and trying to understand the basis for malaria protection.

PI_NAMEs: WARE, RUSSELL E (contact)

PROGRAM_OFFICER_NAME: FRANK, DANIEL J

PROJECT_TERMS: 11 year old;Acute;Address;Affect;Africa;Africa South of the Sahara;African;Age;Algorithms;Angola;Benefits and Risks;Biological Assay;Birth;Blood;Blood specimen;Brain;burden of illness;Cephalic;Cessation of life;Child;Chronic;Clinical;clinical research site;cohort;Collaborations;Country;COVID-19;curative treatments;Data;Databases;Democratic Republic of the Congo;design;Development;Diagnosis;Disease;DNA;Dose;Dose Limiting;Drug Kinetics;Dysmyelopoietic Syndromes;Effectiveness;Endothelium;Enrollment;epidemiologic data;Epidemiology;Erythrocytes;Event;evidence base;exome sequencing;experience;Eye;feasibility testing;Fetal Hemoglobin;Funding;Future;Genetic;Genetic Polymorphism;genome wide association study;Genomic approach;Genomic DNA;Growth;Growth and Development function;Hematological Disease;Hematopoiesis;hydroxyurea;improved;In Vitro;in vitro Assay;Incidence;Income;Inflammation;Inherited;innovation;interpatient variability;Kenya;Kidney;Laboratories;Lead;Leukocytes;Long-Term Effects;Malaria;malaria infection;Maximum Tolerated Dose;Measures;Medical;Medicine;Methodology;Monitor;Morbidity - disease rate;mortality;Multilingualism;Mutation;Myeloid Leukemia;National Heart, Lung, and Blood Institute;Neonatal Screening;neuroprotection;neutrophil;next generation;novel;open label;Oral;Organ;Organ Preservation;parasite invasion;Parasitemia;Patients;Pharmaceutical Preparations;Pharmacodynamics;Pharmacogenomics;Phase;Physical assessment;Pilot Projects;Placebo Control;Predisposition;Prevention;prospective;Puberty;reproductive;Reproductive Health;Research;Research Infrastructure;Research Personnel;research study;Risk;Safety;safety and feasibility;safety testing;Sexual Development;Sickle Cell Anemia;sickling;Single Nucleotide Polymorphism;Site;Spleen;Talents;Testing;Toxic effect;Training;Transfusion;treatment effect;treatment response;Uganda;United States National Institutes of Health;virtual;World Health Organization

PROJECT_TITLE: Realizing Effectiveness Across Continents with Hydroxyurea(REACH): A Phase I/II Pilot Study of Hyroxyurea for Children with Sickle Cell Anemia

STUDY_SECTION: CCHS

STUDY_SECTION_NAME: Clinical Integrative Cardiovascular and Hematological Sciences Study Section[CCHS]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Behavioral and Social Science;Social Determinants of Health

ORG_CITY: WEST LAFAYETTE

ORG_DEPT: OTHER BASIC SCIENCES

ORG_NAME: PURDUE UNIVERSITY

ORG_STATE: IN

PHR: Narrative The cognitive diversity of the biomedical workforce must grow to maximize scientific innovation and enhance U.S. global competitiveness in addressing human health concerns. This growth can be achieved, in part, through greater inclusion of individuals from specific racial and ethnic groups, with physical disabilities, and from challenging socioeconomic backgrounds that are currently significantly underrepresented (UR) in the biomedical sciences. The goal of our program, Purdue PREP, is to enhance the cognitive diversity of the biomedical workforce by increasing the number of college graduates from UR backgrounds that successfully enter and complete a Ph.D. or dual- doctoral degree program in translational biomedical sciences.

PI_NAMEs: HOGENESCH, HARM ;MENDRYSA, SUSAN MARY (contact)

PROGRAM_OFFICER_NAME: STEPANEK, LAURIE ELIZABETH

PROJECT_TERMS: Address;Admission activity;Adopted;Advocate;Aptitude;Area;Awareness;Behavior;Biomedical Research;biomedical scientist;Caliber;career;career awareness;Climate;Cognitive;cognitive enhancement;college;Communication;Communities;Competence;Complex;cultural competence;Degree program;Development;Development Plans;diagnostic tool;disability;diversity and inclusion;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;education research;Educational Curriculum;Emotional Intelligence;Environment;Ethnic Population;Evaluation;experience;Faculty;faculty mentor;Fostering;Future;Goals;graduate school;Growth;Health;Human;improved;Individual;innovation;Institution;interest;Knowledge;Laboratories;Laboratory Personnel;Learning;Life Experience;Measures;member;Mentors;Mentorship;Modernization;novel therapeutics;organizational climate;Outcome;peer coaching;Persons;physically handicapped;Positioning Attribute;Postbaccalaureate;Postdoctoral Fellow;pre-clinical;Prevention strategy;Process;programs;Psychosocial Assessment and Care;Published Comment;racial population;Research;resilience;Scholars Program;school environment;Science;Science, Technology, Engineering and Mathematics;Scientist;Self Efficacy;Self Perception;skills;Social intelligence;socioeconomics;success;Time;Training;translational pipeline;translational study;undergraduate student;Underrepresented Populations;Underrepresented Students;Universities;Work

PROJECT_TITLE: Purdue PREP for Translational Biomedical Sciences

STUDY_SECTION: TWD

STUDY_SECTION_NAME: Training and Workforce Development Study Section - D[TWD-D]


FUNDING_MECHANISM: RESEARCH CENTERS

ORG_CITY: BIRMINGHAM

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: OVERALL: PROJECT NARRATIVE: This type 2 U54 application is derived from the existing, productive Partnership between Morehouse School of Medicine (MSM), Tuskegee University (TU), and the O’Neal Comprehensive Cancer Center (OCCC) at UAB, which is committed to the elimination of cancer health disparities in racial/ethnic minority and underserved populations in the ‘Deep South,’ particularly among African Americans. By leveraging the distinct yet complementary strengths and resources of this Partnership, rigorous and collaborative transdisciplinary research that encompasses basic biologic, preclinical, educational, behavioral, social, and community-based programs leads to evidence-based solutions and an understanding of the causes of cancer health disparities.

PI_NAMEs: MANNE, UPENDER  (contact);RIVERS, BRIAN M.;YATES, CLAYTON

PROGRAM_OFFICER_NAME: RODRIGUEZ, LARITZA MARIA

PROJECT_TERMS: Acceleration;Address;Adherence;African American;African American population;Alabama;anti-cancer research;Applications Grants;Award;Basic Science;Behavioral;Behavioral Research;Bioethics;Bioinformatics;Bioinformatics Shared Resource;Biological;biological research;Biometry;Biotechnology;Cancer Biology;Cancer Burden;cancer care;Cancer Center Planning Grant;Cancer Control;cancer education;Cancer Etiology;cancer genomics;cancer health disparity;Cancer Research Project;cancer risk;career;Clinical;Clinical Cancer Center;Clinical Research;Clinical Trials;Collaborations;Colorectal Cancer;colorectal cancer screening;Combined Modality Therapy;Communities;community involvement;Complement;Comprehensive Cancer Center;Deep South;Development;dietary;Education;education research;Educational Curriculum;Enrollment;Ensure;Ethics;ethnic minority;Ethnic Population;Evaluation;evidence base;Extramural Activities;Faculty;Foundations;Funding;Goals;graduate student;Grant;Health Disparities Research;health disparity;Healthcare Systems;healthy lifestyle;Heart;high school;Hospitals;immunomodulatory strategy;improved;Institution;Intervention;laboratory experience;Latinx;Link;lung cancer screening;Malignant neoplasm of prostate;Malignant Neoplasms;Manuscripts;Medical;Medical Students;member;Methods;Minority Groups;minority investigator;minority student;Minority-Serving Institution;Modeling;Morehouse School of Medicine;multidisciplinary;NCI-Designated Cancer Center;next generation;Outcome;outreach;outreach program;overexpression;Patients;Peer Review;personalized medicine;Physical activity;Pilot Projects;Policies;Population Sciences;Postdoctoral Fellow;pre-clinical;pre-clinical research;Productivity;programs;Provider;Public Health Informatics;Publications;Publishing;racial disparity;racial minority;recruit;Research;research and development;research faculty;Research Personnel;Research Project Grants;Resource Sharing;Resources;Risk Reduction;rural dwellers;Scientist;Secure;social;success;summer research;symposium;System;Testing;theories;Therapeutic Trials;traditional care;Training;Training Programs;tumor-immune system interactions;twelfth grade;undergraduate student;underserved area;Underserved Population;Universities;uptake;Vision

PROJECT_TITLE: 3/3 Morehouse School of Medicine/Tuskegee University/University of Alabama at Birmingham O'Neal Comprehensive Cancer Center Partnership


NIH_SPENDING_CATS: Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Racial and Ethnic Minority Health Research

PI_NAMEs: MANNE, UPENDER  (contact)

PROJECT_TERMS: Administrative Efficiency;Advisory Committees;Alabama;Applications Grants;Area;Bioethics;Bioinformatics;Biometry;Budgets;cancer health disparity;clinical center;Clinical Sciences;Collaborations;Communication;Comprehensive Cancer Center;Data;data management;data sharing;Disparity population;education research;Ensure;Evaluation;experience;Funding;Goals;Human Resources;Infrastructure;Institution;Joints;Leadership;Lilium;Logistics;meetings;member;Minority Groups;minority health;minority health disparity;Monitor;Morehouse School of Medicine;Office of Administrative Management;outreach;Pilot Projects;Policies;Preparation;Principal Investigator;Productivity;Program Evaluation;programs;Progress Reports;Regulation;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Review Committee;Rice;Science;Services;Supervision;symposium;Teleconferences;Translational Research;United States National Institutes of Health;Universities

PROJECT_TITLE: Admin Core


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Services;Machine Learning and Artificial Intelligence;Mental Health;Mental Illness;Precision Medicine;Prevention

ORG_DEPT: PSYCHIATRY

PHR: Project Narrative There is a large and expanding gap between the number of individuals with mental health conditions and the capacity to provide mental health treatment, resulting in a growing public health burden. Digital interventions are a promising path to closing this gap. If successful, the proposed research will result in improved mental health care by expanding the capacity of our health care system and by tailoring treatment to the needs of specific patients, using technology that can be readily adopted by healthcare systems and payers.

PI_NAMEs: BOHNERT, AMY S B;SEN, SRIJAN  (contact)

PROGRAM_OFFICER_NAME: HAIM, ADAM J

PROJECT_TERMS: Acceleration;Address;Adopted;analytical method;analytical tool;Behavior;Behavioral;Cardiovascular Physiology;Caring;Cellular Phone;Clinical;clinical practice;Clinical Trials;Data;demographics;density;depressive symptoms;design;digital intervention;disability;Disease remission;Effectiveness;Emotions;Equipment and supply inventories;evidence base;experience;Frequencies;Goals;Health Services Accessibility;Healthcare Systems;improved;Individual;individualized medicine;ineffective therapies;innovation;Intervention;Knowledge;Lead;Machine Learning;Measures;Mental Depression;Mental Health;Mental Health Services;Methods;mobile computing;Modeling;Monitor;novel;Outcome Assessment;Outpatients;Pathway interactions;patient response;patient variability;Patients;persistent symptom;Persons;Pharmaceutical Preparations;Physical activity;Population;Precision therapeutics;Predictive Factor;predictive modeling;programs;Psychotherapy;Public Health;Quality of life;Recording of previous events;Recovery;recruit;Research;Sample Size;Sampling;sensor;Signal Transduction;Sleep;social engagement;Speed;Surveys;Symptoms;Technology;Time;Translating;treatment duration;treatment effect;treatment response;treatment trial;Waiting Lists;wearable data;wearable device;wearable sensor technology;Work

PROJECT_TITLE: Mobile Technology to Optimize Depression Treatment

STUDY_SECTION: CIDH

STUDY_SECTION_NAME: Clinical Informatics and Digital Health Study Section[CIDH]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: RIVERSIDE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: UNIVERSITY OF CALIFORNIA RIVERSIDE

PHR: Project Narrative: Our goal is to develop novel phage- and CRISPR-based approaches to detect and treat sepsis (one of the leading public health concerns). In this work, we will develop hybrid bio-inorganic nanobots, CRISPR-based devices, and CRISPR-equipped engineered phages to advance sepsis diagnosis, improving the chance of patient survival.

PI_NAMEs: CHEN, JUHONG  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;Bacteria;Bacterial Infections;Bacteriophage M13;Bacteriophages;Binding;Biomedical Research;Blood specimen;Capsid Proteins;Cause of Death;Cessation of life;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Cobalt;combat;Communities;CRISPR/Cas technology;Death Rate;Devices;Diagnosis;Disease;Engineering;Environmental Monitoring;Fiber;Food Safety;Goals;Hospital Mortality;Hospitalization;Hybrids;improved;Life;Magnetic nanoparticles;microfluidic technology;nanobodies;novel;novel strategies;pathogen;Pathogen detection;pathogenic bacteria;Patients;portability;programs;Proteins;Public Health;Research;Resource-limited setting;Sampling;Sensitivity and Specificity;Sepsis;System;Tail;Technology;Testing;tool;United States;Vision;Work

PROJECT_TITLE: Novel approaches to detect and treat sepsis


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Data Science;Health Services;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Prevention;Social Determinants of Health;Urologic Diseases

ORG_CITY: LEBANON

ORG_NAME: DARTMOUTH-HITCHCOCK CLINIC

ORG_STATE: NH

PHR: Project Narrative: Bladder cancer screening by cytopathologists is difficult and prone to high interobserver variability, and to combat this I developed the AutoParis machine learning algorithm as a quantitative diagnostic aid to help the cytopathologist render the correct diagnosis according to the gold standard Paris System for Urine Cytology. But before AutoParis is ready for clinical deployment it must: have its training set expanded, be retrained in a more flexible framework (Pytorch), have a graphical user interface, and be proven non-inferior / superior to standard cytological bladder cancer screening in a head-to-head comparison. This career development award will enable me to gain the necessary computer programming skills so I can advance the AutoParis system to the clinical deployment stage, thus enabling significantly more quantitative and reliable bladder cancer diagnoses (especially in resource-poor areas of the US and the world) and paving the way for other algorithmic diagnostic systems.

PI_NAMEs: VAICKUS, LOUIS JOSEPH (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: Adoption;Age;Algorithms;analog;Arsenic;Atypia;Automation;Award;Belief;Benign;cancer care;cancer diagnosis;Cells;Chemicals;Classification;Clinical;clinical diagnostics;Clinical Medicine;Clinical Services;cluster computing;Code;college;combat;computer program;Computer software;Course Content;Custom;Cystoscopy;Cytology;Cytopathology;Cytoplasm;Data Scientist;Data Set;Demographic Factors;Deposition;design;Development;Diagnosis;Diagnostic;diagnostic algorithm;diagnostic criteria;diagnostic platform;digital;digital decision aid;digital pathology;Discipline;Dyes;Education;Educational process of instructing;Elderly;Elements;empowerment;Environment;Evaluation;experience;Fatigue;flexibility;Future;Glass;Grant;graphical user interface;head-to-head comparison;Health system;Hematuria;High Performance Computing;high risk;hospital care;Human;Human Characteristics;human error;Image;improved;Inflammatory;innovation;Institution;Interobserver Variability;K-Series Research Career Programs;Liquid substance;Machine Learning;machine learning algorithm;machine learning model;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Manuscripts;Mathematics;Mentors;Methods;Microscope;Microscopic;Modeling;Modernization;Morphology;Neoplasms;Nuclear;Output;Pap smear;Paris, France;Pathologist;Pathology;Patients;Periodicals;Play;Preparation;Privatization;Process;prototype;Recurrence;Reproducibility;Resource-limited setting;Risk;Risk Factors;risk stratification;routine screening;Running;Rural;Sampling;screening;Screening for cancer;Services;skills;Slide;Smoking;Specimen;Squamous Cell;Stains;statistics;Statutes and Laws;System;Techniques;Technology;Testing;theories;Training;training data;Transitional Cell Carcinoma;Urine;Urothelial Cell;Urothelium;Validation;virtual;web app;whole slide imaging;Work

PROJECT_TITLE: Semi-automated bladder cancer screening using machine learning: clinical validation and implementation.

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Cancer;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: SCARINCI, ISABEL C (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;Advisory Committees;Alabama;anti-cancer research;Behavioral;Bioethics;Bioinformatics Shared Resource;Biometry;cancer education;cancer genomics;cancer health disparity;clinical trial enrollment;Clinical Trials;Communities;Community Healthcare;Community Outreach;Complex;Comprehensive Cancer Center;Data Collection;Development;Education;education research;ethnic minority;Evaluation;Event;evidence base;Evidence based program;experience;Feedback;Funding;Future;Goals;health care settings;high school;Impact evaluation;innovation;Institution;Joints;Leadership;Link;Logic;Malignant Neoplasms;Medical Students;meetings;Methods;Modeling;Molecular;Morehouse School of Medicine;Nature;Organizational Change;Outcome;Output;outreach program;Pilot Projects;Postdoctoral Fellow;Principal Investigator;Process;process evaluation;programs;racial minority;Recommendation;Reporting;Research;Research Personnel;Research Project Grants;Resource Sharing;Resources;Responsible Person;Rivers;Rural Community;Scientist;sound;synergism;theories;timeline;tool;Translating;Translational Research;undergraduate student;Universities;Urban Community;Work;Writing

PROJECT_TITLE: Planning and Evaluation Core


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Orphan Drug;Rare Diseases

ORG_CITY: PROVO

ORG_DEPT: CHEMISTRY

ORG_NAME: BRIGHAM YOUNG UNIVERSITY

ORG_STATE: UT

PHR: PROJECT NARRATIVE There are substantial gaps in our understanding of the role of the tumor microenvironment, the interaction of tumor cell types and their specific responses to cancer therapies. Mass spectrometry-based proteomics enables deep molecular profiling of protein expression that is invaluable for cancer research, diagnosis and therapy evaluation, but it has lacked the sensitivity and throughput to extend these measurements to the single-cell level for large-scale experiments. We will develop a novel platform for in-depth single-cell profiling that combines nanodroplet sample preparation with ultrahigh-performance and multiplexed liquid chromatography-mass spectrometry with a measurement throughput of hundreds of cells per day, which will greatly accelerate cancer research.

PI_NAMEs: KELLY, RYAN T (contact)

PROGRAM_OFFICER_NAME: COUCH, JENNIFER A

PROJECT_TERMS: Acceleration;Affect;anti-cancer research;Biochemical;cancer cell;cancer therapy;Cancerous;Cell Physiology;Cell Separation;cell type;Cells;Chemicals;Complex;cross reactivity;Cytogenetics;diagnosis evaluation;Diagnostic;Diffusion;Disease;Drug resistance;Drug Targeting;effective therapy;Excision;Exhibits;Experimental Designs;experimental study;Heterogeneity;Hour;Imides;Immune response;immunoregulation;improved;Individual;innovation;instrument;Isotopes;Label;Lead;Libraries;Liquid Chromatography;liquid chromatography mass spectrometry;Literature;Malignant Neoplasms;mass spectrometer;Mass Spectrum Analysis;Measurement;Measures;Mediating;Methods;Molecular;Molecular Profiling;Multiple Myeloma;nano;nanoDroplet;Natural regeneration;neoplastic cell;new technology;Noise;novel;operation;Patients;Peptides;Performance;personalized cancer therapy;Pharmaceutical Preparations;Phase;Phenotype;Pilot Projects;Plasma Cells;Population;predicting response;Predisposition;Preparation;preservation;Process;protein expression;protein profiling;Proteins;Proteome;Proteomics;Reagent;Relapse;Resistance;Resolution;response;RNA;Role;Salts;Sampling;single cell sequencing;single-cell RNA sequencing;Solid;Sorting;System;Technology;Therapeutic;Therapy Evaluation;Time;Tissues;tumor microenvironment;ubiquitin-protein ligase

PROJECT_TITLE: In-depth and label-free proteome profiling of hundreds of single cells per day


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Orphan Drug;Pediatric;Pediatric Cancer;Precision Medicine;Prevention;Rare Diseases

ORG_CITY: MINNEAPOLIS

ORG_DEPT: PEDIATRICS

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: Public Health Relevance Pediatric germ cell tumors (GCTs) are cancers that affect approximately 600 children and adolescents per year in the United States. Survival rates are high for GCTs due to the effectiveness of platinum-based chemotherapy; additional molecular analyses may help inform treatment decisions for the subgroup of patients with poor outcomes. Little is known about why these types of cancers develop, and our analyses evaluating the role of genetic variation may shed some insight into the causes of GCT.

PI_NAMEs: POYNTER, JENNY N. (contact)

PROGRAM_OFFICER_NAME: DAEE, DANIELLE L

PROJECT_TERMS: Accounting;Adolescent;Adult;Affect;Age;age group;biobank;Biological;Biology;California;cancer type;Cancer-Predisposing Gene;case control;Cell Line;Cessation of life;chemotherapy;Child;Childhood;Childhood Germ Cell Tumor;Cisplatin;clinical predictors;clinical risk;Clinical Trials;Complex;Copy Number Polymorphism;Cytotoxic Chemotherapy;Data;Data Set;demethylation;Development;Diagnosis;Disease;disease classification;disorder subtype;DNA;DNA Methylation;Effectiveness;Embryo;Epigenetic Process;Ethnic Origin;Etiology;Event;exome;exome sequencing;Female;Genes;Genetic;genetic analysis;genetic architecture;Genetic Predisposition to Disease;genetic variant;Genetic Variation;genome sequencing;genome wide association study;Germ Cell Cancers;Germ cell tumor;Germ Lines;Goals;Heritability;Histology;Human;improved;improved outcome;in utero;Individual;individualized medicine;insight;Klinefelter's Syndrome;Knowledge;large datasets;Malignant Neoplasms;men;Methods;Methylation;methylation pattern;Michigan;Modification;Molecular;Molecular Analysis;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;Operative Surgical Procedures;Outcome;outcome prediction;Parents;patient subsets;Patients;Pediatric Neoplasm;Pediatric Oncology Group;Pediatric Research;personalized medicine;Platinum;Predisposition;Prognosis;Prognostic Factor;programs;public health relevance;rare variant;Recommendation;Recurrent disease;Relapse;Research;Resistance;Risk;Risk Factors;risk stratification;Role;Sampling;Sex Chromosomes;side effect;Single Nucleotide Polymorphism;Solid Neoplasm;Specimen;Survival Rate;Susceptibility Gene;Syndrome;Testicular Germ Cell Tumor;Testing;tool;trait;Treatment Protocols;tumor;tumor DNA;Turner's Syndrome;United States;Variant;Washington;whole genome;Work;X Chromosome;young adult

PROJECT_TITLE: Genetics and epigenetics of pediatric germ cell tumors

STUDY_SECTION: CHSB

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology B Study Section[CHSB]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS SAN ANTONIO

ORG_STATE: TX

PHR: Neurological diseases and stroke affect the extracellular space among neurons. Determining how  changes in structure of this volume affect neuronal activity will allow a better understanding of how the  brain functions in health and disease. Work performed in this project will provide essential information that  could be of translational use in cases of neuroinflammation and trauma.

PI_NAMEs: SANTAMARIA, FIDEL  (contact)

PROGRAM_OFFICER_NAME: LEENDERS, MIRIAM

PROJECT_TERMS: 3-Dimensional;Acute;Affect;Age;Anatomy;Area;Astrocytes;Automobile Driving;Biochemical;biophysical model;Biophysics;Brain;Brain region;Calcium;Cells;Cerebral hemisphere;Chlorides;Complex;Computer Models;Computer Simulation;Corpus striatum structure;Dendritic Spines;Development;Differential Equation;Diffusion;Disease;Electrophoresis;Electrophysiology (science);Environment;Epilepsy;Excitatory Synapse;experience;experimental study;extracellular;Extracellular Matrix;Extracellular Space;Extracellular Structure;Fluorescence;fluorophore;Future;gamma-Aminobutyric Acid;Gliosis;Health;hippocampal pyramidal neuron;Hippocampus;Image;in vivo;Inhibitory Synapse;Injections;Intercellular Fluid;Knowledge;Label;Laboratories;Lipopolysaccharides;Maps;Measurement;Measures;Microglia;Microscopic;Microscopy;Modeling;Monitor;Mus;nano;Nervous System;Nervous System Disorder;Neuroglia;neuroinflammation;neuronal excitability;Neurons;Neuropil;neurotransmitter release;Neurotransmitters;optogenetics;Osmosis;particle;patch clamp;Pathologic;pharmacologic;Phase;Positioning Attribute;Process;progressive neurodegeneration;Property;Pyramidal Cells;Resolution;Shapes;Signal Transduction;simulation;Slice;Source;Spanish;spatiotemporal;Spectrum Analysis;Stroke;Structure;Swelling;Synapses;Technology;Testing;theories;Thinking;Time;time use;Tissues;Trauma;Trees;ultra high resolution;Vertebral column;Visualization;Work

PROJECT_TITLE: CRCNS: The diffusional complexity of the brain's extracellular space


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Prostate Cancer;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health;Urologic Diseases

PROJECT_TERMS: African American;African American population;Age;Alabama;anti-cancer research;Aptitude;Biomedical Research;cancer education;cancer health disparity;Cancer Research Project;cancer therapy;cancer type;career;career development;Career Mobility;Caring;Clinical Research;college;Colorectal Cancer;Communication;Communities;Comprehensive Cancer Center;Death Rate;Diagnosis;Diverse Workforce;Education;education research;Educational Activities;Educational Curriculum;ethnic disparity;ethnic diversity;ethnic minority;Evaluation;experience;Exposure to;Faculty;Feedback;Fellowship;Funding;Future;Goals;graduate school;graduate student;Grant;hands on research;Health;Health Disparities Research;Healthcare;high school;High School Student;Immersion;improved;Incidence;Informatics;Infrastructure;Institution;interest;Interview;Joints;Laboratories;Latinx;Learning;Link;Malignant neoplasm of lung;Malignant neoplasm of prostate;Malignant Neoplasms;Medical;medical schools;Medical Students;member;men;Mentors;Methods;Minority Groups;Morehouse School of Medicine;mortality;Movement;Outcome;outreach;Patients;Policies;Postdoctoral Fellow;Productivity;programs;Publications;racial disparity;racial diversity;racial minority;recruit;Research;Research Personnel;Research Project Grants;response;rural area;rural setting;Science;Scientist;skills;social media;statistics;Structure;Students;summer program;Training;undergraduate student;Underrepresented Minority;underserved minority;United States National Institutes of Health;Universities;urban area;urban setting

PROJECT_TITLE: Research Education Core


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Data Science;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Physical Injury - Accidents and Adverse Effects;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_NAME: DREXEL UNIVERSITY

ORG_STATE: PA

PHR: PROJECT NARRATIVE Roads and neighborhoods with a built environment that support safe and active transportation are a major priority in low- and middle-income countries (LMICs) due to 90% of road traffic deaths occurring in these locations, especially to pedestrians and other vulnerable road users, yet data on key built environment features at a large scale are not always readily available in these settings. My career goal is to improve population health by examining the effects of the built environment and transportation on health through the adoption and use of methods that can leverage Big Data sources and answer complex, multilevel research questions by overcoming the lack of built environment data in LMICs. The proposed research uses deep learning and advanced statistical methods to create a citywide dataset of built and social environment features in Bogota, Colombia that will provide crucial data to answer questions of their impact on pedestrian injuries and deaths, as well as assessing the presence of health inequities in their distribution and that will lay the groundwork to expand these efforts to more cities in Latin America and other LMICs.

PI_NAMEs: QUISTBERG, DUANE ALEXANDER (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: Adopted;Adoption;Affect;Artificial Intelligence;automated image analysis;Big Data;built environment;burden of illness;career;career development;Cessation of life;Characteristics;Cities;Classification;Collaborations;Colombia;Competence;Complex;computer science;Computer Vision Systems;cost;Country;Data;Data Collection;data infrastructure;Data Set;Data Sources;Databases;deep learning;design;digital imaging;Discipline;Disparity;Education;experience;Future;Goals;Grant;Health;health inequalities;high risk;Human;Image;Image Analysis;improved;Infrastructure;injured;Injury;Label;Latin America;Lead;Location;low and middle-income countries;Machine Learning;Mathematics;Mentors;Methods;Modeling;neighborhood association;Neighborhoods;neural network;pedestrian injury;Perception;Persons;population health;Public Health;Research;Research Methodology;Research Personnel;Research Project Grants;Risk;Safety;skills;social;Social Environment;socioeconomics;spatiotemporal;Statistical Methods;Time;Training;Transportation;Typology;Urban Developments;Urban Health;Vehicle crash;virtual;Writing

PROJECT_TITLE: Built Environment, Pedestrian Injuries and Deep Learning (BEPIDL) Study

STUDY_SECTION_NAME: International and Cooperative Projects - 1 Study Section[ICP1]


NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Lung;Mental Health;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: DURHAM

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrations/Public Health Relevance There is an urgent need to develop and evaluate stress management interventions in Black adults with asthma to help improve asthma medication adherence and asthma control and reduce asthma disparities. In this study, I will develop and evaluate a new stress management intervention, called CALM, that is designed to help Black adults cope with common stressors such as psychosocial issues, difficulty managing their asthma, and financial difficulty. By helping Black adults with asthma manage their stress we can potentially improve their quality of life and prevent asthma attacks.

PI_NAMEs: RILEY, ISARETTA  (contact)

PROGRAM_OFFICER_NAME: FREEMER, MICHELLE M

PROJECT_TERMS: acceptability and feasibility;Accident and Emergency department;Address;Adherence;adherence rate;Adult;Asthma;asthma exacerbation;Behavior;Biometry;Biostatistical Methods;black men;Black Populations;Black race;black women;career;Caregiver Burden;Chronic stress;Clinical;clinical practice;Clinical Psychology;Cognitive;cohort;Cohort Studies;Communities;coping;Coping Skills;Cross-Sectional Studies;Death Rate;design;Disparate;Disparity;Doctor of Philosophy;Economics;effective intervention;Effectiveness;Enrollment;Ensure;experience;Feasibility Studies;Focus Groups;Foundations;Funding;General Population;Health;Health behavior;health disparity;Health system;Hospitalization;hospitalization rates;improved;Individual;innovation;Intervention;Jackson Heart Study;Life;medication compliance;medication nonadherence;Mentors;Mentorship;Minor;Modeling;Morbidity - disease rate;mortality;Narration;National Heart, Lung, and Blood Institute;novel;Occupations;Oral;Outcome;Participant;patient engagement;Patients;perceived discrimination;Personal Satisfaction;Persons;pilot test;prevent;Problem Solving;programs;Protocols documentation;Provider;psychosocial;Psychosocial Influences;Psychosocial Stress;public health relevance;Qualitative Methods;Quality of life;Randomized;Randomized, Controlled Trials;Reporting;Research;Resources;Self Management;Severities;skills training;social;Source;Steroids;Stimulus;Stress;Stress and Coping;stress management;stress state;stressor;Techniques;Testing;theories;therapy design;Transact;Waiting Lists;Withdrawal

PROJECT_TITLE: Coping with Asthma through Life Management (CALM)


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Bioengineering;Congenital Structural Anomalies;Digestive Diseases;Genetics;Lymphatic Research;Pediatric

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: PROJECT NARRATIVE Gut malrotation is a birth defect of abnormal intestinal rotation that occurs once in 500 live births, and predisposes affected babies to volvulus, a catastrophic strangulation of the intestine and its blood supply. Making use of the accessibility of the chicken egg, genetic mouse models, and force measurements we have developed the tools to answer fundamental questions surrounding correct gut rotation, focused here on the molecules governing physical forces that shape the intestine and pattern gut vasculature. Our work will reveal how the gut rotates and why this process fails, with the goal to improve diagnosis and increase survival in neonates.

PI_NAMEs: KURPIOS, NATASZA A (contact)

PROGRAM_OFFICER_NAME: GREENWEL, PATRICIA

PROJECT_TERMS: Actomyosin;Address;Affect;Alleles;Anisotropy;Architecture;Bilateral;Birds;Blood Vessels;BMP4;cell behavior;cell motility;Cell Physiology;Cell Polarity;Cells;Chick Embryo;chicken egg;Chickens;clinically significant;Computer Models;Congenital Abnormality;craniofacial;Data;Development;Diagnosis;Diagnostic;Disease;Dorsal;dosage;Dose;driving force;Embryology;Embryonic Development;Endothelial Cells;Enzymes;Equilibrium;Extracellular Matrix;Failure;fascinate;Feedback;gain of function;Gene Expression;Gene Targeting;Genes;Genetic;genetic manipulation;Genetic Transcription;Goals;Handedness;Hyaluronan;improved;Intestinal Volvulus;Intestines;Isomerism;Knockout Mice;Left;Life;Link;Live Birth;Location;Lymphatic;lymphatic development;lymphatic malformations;lymphatic vessel;Lymphedema;Malignant Neoplasms;Measurement;mechanical force;Mechanics;mechanotransduction;Mesenchymal;Mesenchyme;Mesentery;Midgut;Modeling;Molecular;Morphogenesis;mouse genetics;mouse model;Mus;Muscle;mutant;Myosin ATPase;neonate;Newborn Infant;Nodal;Organ;Organogenesis;Pattern;pediatric patients;permissiveness;Physical condensation;prevent;Process;Property;quantitative imaging;Regulation;Repression;Reproducibility;response;Rieger syndrome;Role;Rotation;Shapes;Side;Signal Transduction;Specific qualifier value;Stress;System;Technology;Testing;Time;Tissues;tool;Translating;Translations;transmission process;Tube;Vascular blood supply;Vascularization;vasculogenesis;Vertebrates;Work

PROJECT_TITLE: Mechanisms underlying asymmetric rotation and morphogenesis of the midgut


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Cancer;Cerebrovascular;Clinical Research;Gene Therapy;Genetics;Hematology;Immunotherapy;Lymphatic Research;Lymphoma;Neurosciences;Orphan Drug;Rare Diseases

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Dr. Gust is proposing a career development program to become a translational clinician-scientist who works on improving the brain health of children and young adults with cancer. In this project, she will use a mouse model to examine the causes of life-threatening neurotoxicity that occurs during cancer immunotherapy with chimeric antigen receptor (CAR) T cells. The results from this work will pave the way toward better strategies to prevent and treat CAR T cell neurotoxicity, which will make this revolutionary therapy safer and decrease the need for toxic chemotherapy and radiation.

PI_NAMEs: GUST, JULIANE  (contact)

PROGRAM_OFFICER_NAME: REZAIZADEH, KAVON PAUL

PROJECT_TERMS: Address;Adherence;Adhesions;Affect;Animal Model;animal model development;Animals;Area;arteriole;Astrocytes;Award;Basement membrane;Behavior;Biology;Blood;Blood - brain barrier anatomy;Blood capillaries;Blood flow;Blood Platelets;Blood Vessels;blood-brain barrier disruption;Brain;brain dysfunction;Brain Edema;brain health;cancer cell;cancer immunotherapy;CAR T cell therapy;career;career development;CD19 gene;Cell Adhesion;Cell Count;cell killing;Cell surface;cell type;Cells;Cellular immunotherapy;Cephalic;Cerebral Edema;cerebral microbleeds;cerebrovascular;Cerebrovascular Circulation;Cerebrum;chemotherapy;Chemotherapy and/or radiation;Child Health;chimeric antigen receptor;chimeric antigen receptor T cells;clinical decision-making;cognitive change;common symptom;Communication;Control Groups;Cortical vasculature;cranium;cytokine;cytokine release syndrome;Data;Delirium;Dextrans;Diameter;Dose;Edema;Electroencephalography;Electron Microscopy;Endothelial Cells;Endothelium;Erythrocytes;experimental analysis;Experimental Designs;Extravasation;Flow Cytometry;Functional disorder;Goals;Hematologic Neoplasms;hemodynamics;Hemorrhage;Histology;Human;hypoperfusion;Image;Imaging Techniques;immune cell infiltrate;Immunology;Immunotherapy;Impaired cognition;Impairment;improved;in vivo;in vivo two-photon imaging;Inbred Strain;Individual;Inflammatory;Infusion procedures;Injury;innovation;interstitial;Knowledge;Label;Leadership;Leucocytic infiltrate;leukemia/lymphoma;Leukemic Cell;Leukocytes;Life;Link;Lymphoma;Malignant Neoplasms;Measures;Mechanics;Mentors;Metalloproteases;model development;Modeling;Molecular;mouse model;Mus;Neurologic;Neurologic Dysfunctions;Neurology;neurotoxicity;neurovascular unit;novel;Oncology;Pathway interactions;Patient Care;Patients;Perfusion;Pericytes;postcapillary venule;Preparation;prevent;Program Development;Proteins;Random Allocation;receptor;Refractory;Relapse;Research;Resolution;rhodamine 6G;Risk;Risk Factors;Science;Scientist;Seizures;Severities;Shapes;skills;Speed;Structure;Surface;Syndrome;systemic inflammatory response;T-Cell Proliferation;T-Cell Receptor Therapy;T-Lymphocyte;Testing;Therapeutic;therapeutic development;Thinness;Tight Junctions;Toxic effect;Tracer;Training;translational physician;vasoconstriction;venule;Vesicle;Visualization;Wild Type Mouse;Work;young adult

PROJECT_TITLE: Blood Brain Barrier Disruption during Chimeric Antigen Receptor (CAR) T cell therapy

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-1 Study Section[NST-1]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: SCHOENBERGER, YU-MEI M (contact)

PROJECT_TERMS: Address;Advanced Malignant Neoplasm;African American;African American population;Alabama;anti-cancer research;Attitude;Awareness;Behavior;Belief;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Cancer health equity;Cancer Patient;cancer prevention;cancer risk;cancer therapy;Catchment Area;Clinical;Clinical Research;clinical trial enrollment;Clinical Trials;Communities;Community Health;Comprehensive Cancer Center;design;Disease;Early Diagnosis;Education;education resources;Environment;Equity;Evaluation;evidence base;Genetic;Genomics;Goals;health disparity populations;Institution;interest;Joints;Knowledge;Latinx;Latinx population;Logic;Malignant Neoplasms;Medicine;Minority Participation;Modeling;Morehouse School of Medicine;National Cancer Institute;Outcome;Outcome Measure;outreach;Participant;patient navigation;Population;Population Heterogeneity;precision oncology;preference;Prevention;Privacy;programs;recruit;Research;Research Project Grants;research study;Resources;Rural Community;Safety;Scientific Advances and Accomplishments;Services;Standardization;Surveys;Tablets;Technology;theories;Therapeutic Clinical Trial;Training;Trust;Underserved Population;United States National Institutes of Health;Universities;Urban Community

PROJECT_TITLE: Outreach Core


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Chronic Pain;Clinical Research;Comparative Effectiveness Research;Dental, Oral, and Craniofacial Disease;Health Services;Pain Research;Patient Safety;Primary Health Care;Telehealth

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Project Narrative This study will provide insight on pain levels experienced by patients caused by dental procedures by using using mobile phones. We will also be able to gage to what extend dental providers are interested in adopting mHealth technology and we will learn how much patients like to be engaged with text messaging to report their post-operative complications.

PI_NAMEs: WALJI, MUHAMMAD  (contact)

PROGRAM_OFFICER_NAME: FISCHER, DENA

PROJECT_TERMS: Accounting;Acute;Adherence;Adopted;Adverse event;American;Caring;Cellular Phone;Clinic;Clinical;connected health;cost;Data;Data Collection;Dental;Dental Care;Dental Clinics;Dental General Practice;Dental Offices;Dentistry;Dentists;design;Development;Environment;Equipment and supply inventories;experience;Fostering;functional status;Goals;Grant;health information technology;Health Professional;Health Technology;Human Resources;improved;innovation;insight;interest;Learning;Local Anesthetics;Manuals;mHealth;mobile application;Modeling;Monitor;Network Infrastructure;Notification;Observational Study;operation;Operative Surgical Procedures;Pain;Pain intensity;Pain management;Pain Measurement;patient engagement;Patient Monitoring;Patient Outcome Questionnaire;Patient Outcomes Assessments;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;Phase;Pilot Projects;pilot test;Postoperative Complications;Postoperative Pain;Postoperative Period;Practice based research;practice-based research network;prescription opioid;Procedures;Prospective, cohort study;Protocols documentation;Provider;Pulp Canals;Quality of life;recruit;Reporting;Research;satisfaction;shared decision making;Site;Societies;surgical pain;Symptoms;Technology;technology platform;Testing;Text Messaging;Time;time interval;Toothache;Training;treatment planning;usability;Visit;Workload

PROJECT_TITLE: Understanding Pain after Dental Procedures


ADMINISTERING_IC: TR

ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Clinical Research;Clinical Trials and Supportive Activities;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: ROCHESTER

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Second only to joint replacement and spinal fusion surgeries, procedures to repair tendon and other soft connective tissues represent ~20% (~2.5 million) of all major musculoskeletal procedures. The incomplete understanding of the complex cellular and molecular processes in tendon injury has hindered the development of biological therapies for regenerative tendon repair. This proposal develops a human microphysiological system to elucidate the roles of inflammation and fibrosis in this pathology and enable evaluation of safety and efficacy of disease-modifying treatments to inform clinical trials.

PI_NAMEs: AWAD, HANI A (contact);MCGRATH, JAMES L;MILLER, BENJAMIN L

PROGRAM_OFFICER_NAME: HARGROVE, PASSLEY R

PROJECT_TERMS: 3-Dimensional;Acceleration;Acute;Adhesions;Antibodies;Biological;Biological Assay;biological development;Biological Markers;Biological Models;biomarker selection;Blood flow;Blood Tests;Blood Vessels;Cell Cycle Regulation;cell motility;Cells;Chronic;Cicatrix;Circulation;Clinical;Clinical Trials;clinically relevant;Collagen;Complex;Confocal Microscopy;Connective and Soft Tissue;design;Detection;Devices;Disease;disease model;Dose;drug candidate;drug discovery;drug efficacy;Drug Screening;druggable target;efficacy evaluation;efficacy testing;Endothelial Cells;Endothelium;Engineering;Enzyme-Linked Immunosorbent Assay;Evaluation;experience;Extracellular Matrix;Extravasation;FDA approved;Fibroblasts;Fibrosis;Flexor;FRAP1 gene;Gamma-H2AX;Gene set enrichment analysis;Goals;healing;Health;high throughput screening;Human;human induced pluripotent stem cells;human tissue;Hydrogels;Image;Immunology;Impairment;improved;In Situ;induced pluripotent stem cell;induced pluripotent stem cell technology;Infiltration;Inflammation;Inflammation Mediators;Inflammatory;inhibitor;injured;innovation;intercellular communication;Intervention Trial;joint function;Label;Libraries;Link;Macrophage;manufacture;Measurement;Measures;Mechanics;Mediating;Membrane;meter;Microfabrication;Microfluidic Microchips;Microfluidics;microphysiology system;Microscopic;microscopic imaging;Microscopy;Molecular;mouse model;mTOR Inhibitor;Mus;Musculoskeletal;Myofibroblast;nano;nanofabrication;Nanoporous;next generation sequencing;Operative Surgical Procedures;Optics;organ on a chip;Outcome;Paracrine Communication;Pathology;Patients;Periodicity;Permeability;Pharmaceutical Preparations;Phase;Phenotype;photonics;PI3K/AKT;Porosity;preclinical trial;primary outcome;Procedures;Process;programs;Protein Secretion;Publishing;regenerative therapy;repaired;Replacement Arthroplasty;Role;Safety;Sampling;SDZ RAD;secondary outcome;senescence;Sensitivity and Specificity;sensor;sensor technology;Serum;Side;Signal Transduction;Silicon;Sirolimus;Spinal Fusion;System;Tendinopathy;Tendon Injuries;Tendon structure;Testing;Therapeutic;Time;Tissue Engineering;Tissues;Transforming Growth Factor beta;Translating;Vascular Endothelial Cell;virtual clinical trial

PROJECT_TITLE: A microphysiological system of tendon inflammation and fibrosis for drug screening and efficacy testing


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PI_NAMEs: GRIZZLE, WILLIAM E. (contact)

PROJECT_TERMS: Address;Advocate;Alabama;anti-cancer research;Behavioral;Behavioral Research;Bioethical Issues;Bioethics;Bioethics Consultants;Biological Sciences;Biomedical Research;cancer clinical trial;cancer genomics;cancer health disparity;Clinical;Clinical Research;Clinical Trials;Collaborations;Communities;Community Health;Competence;Comprehensive Cancer Center;Consultations;design;Education;Education and Outreach;education research;Educational process of instructing;Endowment;Enrollment;Ensure;Ethical Issues;Ethics;ethnic minority;Evaluation;Faculty;Genomics;Good Clinical Practice;Guidelines;health disparity;Health Policy;Human Resources;Informed Consent;Institution;Laws;Logic;Malignant Neoplasms;medically underserved;Methods;minority communities;Modeling;Morehouse School of Medicine;new technology;online course;Outcome;outreach;Participant;patient navigator;Patients;Policies;Process;programs;racial minority;Recommendation;Research;Research Ethics;Research Personnel;Research Project Grants;Resource Sharing;rural area;social;Students;symposium;Thinking;tool;Training;Trust;undergraduate student;underserved community;underserved urban area;Universities

PROJECT_TITLE: Core 1: Bioethics Shared Resource


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome

PI_NAMEs: BAE, SEJONG  (contact)

PROJECT_TERMS: Advanced Malignant Neoplasm;Alabama;anti-cancer research;Applications Grants;Basic Science;Behavioral Sciences;Bioethics;Bioinformatics;bioinformatics resource;Bioinformatics Shared Resource;biomedical informatics;Biometry;cancer education;cancer health disparity;Cancer Research Project;career;career development;ChIP-seq;Clinical Research;Collaborations;Comprehensive Cancer Center;computer science;Consultations;Data;Data Analyses;data management;data mining;Data Science;Dedications;Development;DNA sequencing;Education;education research;Ensure;Epidemiology;Epigenetic Process;Evaluation;exome sequencing;Faculty;Funding;Grant;Incidence;Informatics;Institution;Manuscripts;Medical;Medicine;member;Mentorship;metabolomics;Methodology;Methods;Methylation;microbiome research;Minority-Serving Institution;miRNA expression profiling;Morehouse School of Medicine;mortality;multiple omics;next generation sequencing;outreach;Pathology;Pilot Projects;population based;Preparation;Productivity;professor;programs;racial disparity;Reproducibility;Research;Research Design;Research Personnel;Research Project Grants;Research Support;Resource Sharing;Risk;single cell analysis;single cell genomics;skills;sound;statistics;success;Technical Expertise;Training;transcriptome sequencing;Translational Research;Ubiquitination;Universities;Work

PROJECT_TITLE: Core 2: Biostatistics/Bioinformatics Shared Resource


NIH_SPENDING_CATS: Behavioral and Social Science;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Services;Lung;Lung Cancer;Prevention

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The proposed research is relevant to public health because leveraging a social media platform to increase awareness among individuals eligible for lung cancer screening is a novel untapped platform to reach vulnerable, high-risk individuals. Thus, the proposed research is relevant to the cancer research mission of the National Cancer Institute and, more broadly, the National Institutes of Health’s mission to seek fundamental knowledge about the nature and behavior of individuals and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability through early detection of lung cancer.

PI_NAMEs: CARTER-BAWA, LISA  (contact)

PROGRAM_OFFICER_NAME: EVERSON, NICOLE MARIE

PROJECT_TERMS: Address;Adoption;Advertisements;Advisory Committees;Age;American;American Cancer Society;anti-cancer research;Area;Awareness;Behavior;Communication;Communication Tools;Communities;compare effectiveness;Computers;design;disability;Ecosystem;effectiveness testing;Eligibility Determination;Facebook;Fostering;Goals;Health;Health behavior change;health belief;health communication;Healthcare Systems;high risk;high risk population;human old age (65+);improved;Individual;innovation;Insurance Carriers;interest;Intervention;Knowledge;Learning;Life;Link;Lung;lung cancer screening;Malignant neoplasm of lung;Malignant Neoplasms;Medicare;Methods;Misinformation;Mission;mortality;National Cancer Institute;Nature;novel;Online Systems;Participant;patient population;Patients;Population;Preventive service;Public Health;Randomized;Randomized, Controlled Trials;Recommendation;recruit;Research;Risk;screening;Self Efficacy;shared decision making;Smoker;social media;support tools;Testing;trial design;United States National Institutes of Health;United States Preventative Services Task Force;uptake;Work

PROJECT_TITLE: Leveraging Social Media to Increase Lung Cancer Screening Awareness, Knowledge and Uptake in High-Risk Populations

STUDY_SECTION: HPC

STUDY_SECTION_NAME: Health Promotion in Communities Study Section[HPC]


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Cost Effectiveness Research;Health Services;Nutrition;Obesity;Prevention

ORG_DEPT: OTHER HEALTH PROFESSIONS

PHR: Log2Lose is a clinical trial that seeks to evaluate whether people lose more weight when they  receive small financial incentives for weekly weight loss or diet logging. Study software collects  and analyzes weight data from a cellular-connected scale and dietary data from a smartphone dietary  application ('app'). Algorithms analyze these data to determine if participants meet the criteria  to receive an incentive. Participants receive a text message about whether they earned an  incentive, and, if so, receive payment on a debit card.

PI_NAMEs: OLSEN, MAREN K.;SHAW, RYAN JEFFREY (contact)

PROGRAM_OFFICER_NAME: DONZE, LAURIE FRIEDMAN

PROJECT_TERMS: Address;adult obesity;Algorithms;analytical tool;Behavioral;Body Weight decreased;Cellular Phone;Classification;Clinical;Clinical Data;Clinical Management;clinical research site;Clinical Trials;clinically significant;Communication;Communities;Community Trial;Computer software;cost;cost effective;cost effectiveness;cost-effectiveness ratio;Data;Data Collection;data communication;Data Coordinating Center;data integration;data integrity;data management;data quality;data sharing;design;Diet;dietary;digital;digital health;Educational process of instructing;effectiveness evaluation;electronic data;Electronics;Elements;Environment;evidence base;experience;extrinsic motivation;financial incentive;four-arm study;Funding;future implementation;Goals;Good Clinical Practice;Health;Health behavior and outcomes;Home;Human;improved;Incentives;incremental cost-effectiveness;Individual;Information Technology;Infrastructure;Intervention;intervention cost;intervention effect;intrinsic motivation;Joints;Lead;Leadership;Maintenance;Measures;Mediating;member;Monitor;National Heart, Lung, and Blood Institute;novel;Obesity;Outcome;Participant;participant retention;Patient Self-Report;Patients;payment;Persons;Phase;Population;Positioning Attribute;Preparation;Prevalence;primary endpoint;Probability;Process;program costs;Program Effectiveness;programs;protocol development;Protocols documentation;Publications;Qualifying;Quality of life;Randomized;randomized, clinical trials;Randomized, Controlled Trials;recruit;relative effectiveness;Report (document);Reporting;Research Design;Rewards;Role;Safety Management;Secure;Single-Blind Study;Site;Statistical Data Interpretation;System;Technology;technology platform;Testing;Text Messaging;Time;tool;Training;transmission process;trial planning;Universities;Weight;weight loss intervention;weight loss program;weight maintenance;Weight maintenance regimen

PROJECT_TITLE: (2/2) Log2Lose: Incenting Weight Loss and Dietary Self-Monitoring in Real Time to Improve Weight Management

STUDY_SECTION: CLTR

STUDY_SECTION_NAME: Clinical Trials Review Study Section[CLTR(MA)]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Social Determinants of Health

PI_NAMEs: MANNE, UPENDER  (contact);RIVERS, BRIAN M.;YATES, CLAYTON

PROJECT_TERMS: Affect;Alabama;Automobile Driving;Biological;bisulfite sequencing;Black American;black patient;Black race;Cancer Biology;Cells;chemical group;Clinical;cohort;Collaborations;comparative;Comprehensive Cancer Center;Data;Deep South;Diagnosis;Disparate;Disparity;DNA;DNA Methylation;Environment;Environmental Risk Factor;Epigenetic Process;epigenetic regulation;Ethnic Population;experience;Formalin;Gene Expression;Gene Expression Profile;Gene Expression Regulation;gene network;gene product;Generations;Genes;Genetic;Genetic study;Genome;genomic profiles;Genomics;Goals;Guidelines;Health;Hormones;Immune system;Incidence;Individual;Institution;Lasers;Life Style;Malignant neoplasm of pancreas;Malignant Neoplasms;Methods;Modernization;Modification;Morehouse School of Medicine;Mutation;Normal tissue morphology;Outcome;Pancreas;Paraffin Embedding;Pathway interactions;patient population;Patients;Population;protein biomarkers;Race;racial population;Research;Resolution;Sampling;Severity of illness;socioeconomics;Stains;Stress;stressor;System;Testing;Tissue Microarray;transcriptome;tumor;Universities


NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease;Pediatric;Pediatric Cardiomyopathy;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a hereditary and progressive heart disease that can cause cardiac dysfunction, fatal ventricular arrhythmias and sudden cardiac death, affecting as many as 1:1000 Americans. To date, there is an unmet need for effective treatment of patients with ARVC. This proposal identifies a new mechanism underlying the disease and will lead to novel breakthrough therapeutics that improve quality and life expectancy for patients with the disease.

PI_NAMEs: SONG, LONG-SHENG  (contact)

PROGRAM_OFFICER_NAME: BALIJEPALLI, RAVI C

PROJECT_TERMS: Action Potentials;Address;Affect;age related;American;Arrhythmia;Arrhythmogenic Right Ventricular Dysplasia;Cardiac;Cardiac Myocytes;Cardiovascular Diagnostic Techniques;carvedilol;Catecholamines;Cell Adhesion;Cells;Clinical;Clinical Trials;Collagen;Communication;congenic;coronary fibrosis;Coupling;CRISPR/Cas technology;Cyclic AMP-Dependent Protein Kinases;Data;Defect;Deposition;Desmosomes;Disease;Disease Progression;effective therapy;Emotional;Exercise;Exhibits;Fibronectins;Functional disorder;Gene Mutation;Genes;Goals;Guidelines;Heart;Heart Diseases;Heart failure;Heart Transplantation;Hereditary Disease;Homeostasis;Human;Hyperactivity;Impairment;improved;Induced Mutation;Infiltration;Infusion procedures;Inherited;insight;Integrins;Intercellular Junctions;Intervention;Isoproterenol;knock-down;Knock-in;Knock-in Mouse;Knockout Mice;Knowledge;Life;Life Expectancy;Link;MAPK3 gene;Mass Spectrum Analysis;Measures;Mechanical Stress;Mechanics;Mediating;Modeling;Molecular;mouse model;Mus;Muscle Cells;mutant;Mutation;Myocardial dysfunction;Myocardium;Nature;novel;novel therapeutics;Outcome;Pathogenicity;Pathologic;Pathology;Pathway interactions;Patients;Phenotype;Phosphorylation;Predisposition;prevent;Primary Myocardial Diseases;Probability;Process;Proteins;proteomic signature;Quality of life;response;Right Ventricular Dysfunction;Role;Ryanodine Receptor Calcium Release Channel;RyR2;Sampling;Sarcoplasmic Reticulum;Signal Transduction;Stress;sudden cardiac death;Sympathectomy;Symptoms;Tachycardia;Techniques;Testing;Therapeutic;Time;Tissues;transcriptomics;Ubiquitin;Ventricular;Ventricular Arrhythmia;Ventricular Tachycardia

PROJECT_TITLE: ERK1/2-Integrin Signaling in Desmosome-Dyad Crosstalk

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CVRS-C(02)]


NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Digestive Diseases;Genetic Testing;Genetics;Machine Learning and Artificial Intelligence;Pancreatic Cancer;Prevention;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Project Narrative Pancreatic cancer is the deadliest of the common cancers and one of commonest causes of cancer death. Detecting pancreatic cancer at an early stage greatly improves survival from pancreatic cancer. We propose to evaluate a tumor marker gene blood test for pancreatic cancer early detection in a clinical trial and to evaluate other promising tests aimed at improving the early detection of pancreatic cancer in patients with an increased susceptibility undergoing pancreatic surveillance.

PI_NAMEs: GOGGINS, MICHAEL G. (contact)

PROGRAM_OFFICER_NAME: YOUNG, MATTHEW R

PROJECT_TERMS: Accounting;advanced disease;Affect;Age;Aneuploidy;artificial intelligence method;Biological Markers;Biological Specimen Banks;Blinded;Blood;Blood specimen;Blood Tests;CA-125 Antigen;CA-19-9 Antigen;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer imaging;Case/Control Studies;Cessation of life;Characteristics;clinical diagnosis;Clinical Trials;cohort;Cyst Fluid;Data;Databases;deep learning;design verification;Detection;Development;Diabetes Mellitus;Diagnosis;Diagnostic;diagnostic panel;Diagnostic Sensitivity;Diagnostic Specificity;Diagnostic tests;disorder control;Drops;early detection biomarkers;Early Diagnosis;Evaluation Studies;Family;Future;Genetic;Genetic Markers;genetic testing;genetic variant;Genotype;glycosylation;Guidelines;High grade dysplasia;high risk;high risk population;Icterus;Image;improved;improved outcome;Incidence;Individual;Juice;Lead;Magnetic Resonance;Magnetic Resonance Spectroscopy;Malignant neoplasm of pancreas;Malignant Neoplasms;Metabolic;Metabolic syndrome;Methods;microbiome;Multicenter Studies;novel marker;Outcome;Pancreas;pancreas imaging;pancreatic cancer patients;Pancreatic Cyst;Pancreatic Ductal Adenocarcinoma;pancreatic juice;pancreatic neoplasm;patient subsets;Patient-Focused Outcomes;Patients;Performance;Plasma;pre-clinical;Predisposition;Prevalence;programs;prospective;Recording of previous events;Reference Values;Research Personnel;Resectable;Resolution;Resources;sample collection;Sampling;screening;Screening for cancer;SEER Program;Serum;Site;Specificity;Specimen;Subgroup;surveillance imaging;Testing;Time;Tissue Banks;Tissues;Training;Tumor Markers;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Using markers to improve pancreatic cancer screening and surveillance: a multi-center study


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Psychosis;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_CITY: CAMBRIDGE

ORG_NAME: BROAD INSTITUTE, INC.

ORG_STATE: MA

PHR: Project Narrative The Populations Underrepresented in Mental illness Association Studies (PUMAS) Project will collect samples from 17,000 individuals with severe mental illness from across African and the Americas to create a total sample dataset of 183,000 from across Africa and the Americas. We will generate and analyze whole genome sequencing data on 40,000 schizophrenia patients, 40,000 bipolar patients and 40,000 controls to learn the similarities and differences of the genetic architecture of severe mental illness across diverse ancestries and environments.

PI_NAMEs: MARTIN, ALICIA ;NEALE, BENJAMIN MICHAEL (contact)

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Abbreviations;Africa;African;African ancestry;Americas;Area;Biological;Bipolar Disorder;bipolar patients;Code;cohort;Collaborations;Collection;Computerized Medical Record;Copy Number Polymorphism;Data;Data Set;data sharing;Diagnostic;Disease;Environment;Ethnic Origin;European ancestry;exome;exome sequencing;Gene Frequency;Generations;Genes;Genetic;genetic architecture;Genetic Research;Genetic study;Genetic Variation;genome sequencing;Genomics;Genotype;health care disparity;Individual;insight;International;Interview;knowledge base;Latin American;Latino;Latino Population;Learning;Letters;Linkage Disequilibrium;Maps;Medicine;Mental disorders;Meta-Analysis;Mood Disorders;Mutation;National Institute of Mental Health;Native American Ancestry;Native Americans;neuropsychiatry;Outcome;Patients;Phenotype;polygenic risk score;Population;Population Control;Population Heterogeneity;Principal Component Analysis;psychiatric genomics;Psychiatry;psychogenetics;Psychoses;Psychotic Disorders;Quality Control;Questionnaires;rare variant;recruit;Reduce health disparities;Research Personnel;response;risk variant;Sample Size;Sampling;Sampling Studies;Schizoaffective Disorders;Schizophrenia;screening;severe mental illness;Severities;Single Nucleotide Polymorphism;South Africa;South America;success;Underrepresented Populations;Variant;variant detection;whole genome

PROJECT_TITLE: 1/4 Powering Genetic Discovery for Severe Mental Illness in Latin American and African Ancestries


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

ORG_CITY: PITTSBURGH

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CARNEGIE-MELLON UNIVERSITY

PHR: PROJECT NARRATIVE This project will design an ingestible electronic device that can non-invasively modulate the activity of sensory neurons in the gut. Using pig models, ingestible device with flexible electrodes will pace nerves that innervate the gut while brain activity will be recorded using fMRI. If successful, ingestible devices that modulate the gut- brain axis can serve as a platform technology to better understand and treat digestive and metabolic diseases including obesity and diabetes.

PI_NAMEs: DICKEY, ELIZABETH C (contact)

PROGRAM_OFFICER_NAME: FALCONE, JESSICA

PROJECT_TERMS: 20 year old;Address;Adopted;afferent nerve;Afferent Neurons;American;Anatomy;Anesthesia procedures;Animals;Area;biomaterial compatibility;Biomimetics;Brain;Brain Stem;Cells;cellular transduction;Central Nervous System;Charge;Chemicals;Clinical;cognitive function;combat;Communication;cost;Coupled;Cues;Deglutition;design;Devices;Diabetes Mellitus;Diagnosis;Digestive System Disorders;Disease Progression;Duodenum;Eating;elastomeric;Elastomers;electric impedance;Electric Stimulation;Electrodes;Electronics;Endoscopy;Face;Family suidae;Fasting;flexibility;Food;Frequencies;Functional Magnetic Resonance Imaging;Future;Gastric Pacemakers;gastrointestinal system;Gastrointestinal tract structure;Gastroparesis;gut bacteria;gut-brain axis;heart rate variability;Hormones;Human;human subject;Image;Implant;In Vitro;in vivo;in vivo evaluation;Incidence;Inflammation;Injections;Insulin Resistance;Intestines;invention;Length;Link;Location;Magnetic Resonance Imaging;Maps;Measures;mechanical properties;Mechanics;Memory;Metabolic;Metabolic Diseases;Metabolism;microbial composition;microbiome;Miniature Swine;Monitor;Motility;multi-electrode arrays;Nerve;Nervous System Disorder;neural;neural circuit;Neurons;Non-Insulin-Dependent Diabetes Mellitus;novel strategies;Nutrient;Obesity;Operative Surgical Procedures;Oral;Organ;Pathway interactions;Perception;Phase;Physiologic pulse;Physiological;pill;Play;Polymers;porcine model;Power Sources;Prediabetes syndrome;prevent;Printing;Radial;Resolution;response;Rewards;Risk;Roentgen Rays;Role;Satiation;Sensory;Serotonin;Shapes;Signal Transduction;Signaling Molecule;Small Intestines;small molecule;spatiotemporal;Specialized Epithelial Cell;Stomach;Surface;Surgical sutures;Techniques;Technology;technology platform;Testing;Vagotomy;Vagus nerve structure;X-Ray Computed Tomography

PROJECT_TITLE: Ingestible Electronic Devices for Non-Invasive Vagal Stimulation

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Depression;Heart Disease;Mental Health;Prevention;Sleep Research

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE In spite of the rates of sleep disturbance in spousal bereavement and its detrimental impact on mental and physical health, it is currently unknown whether interventions aimed at improving sleep in this population are either feasible or effective. This study will develop a targeted behavioral intervention for sleep disturbance among spousally bereaved adults and test it for feasibility, acceptability, and preliminary effects. Given the efficacy of behavioral treatment for sleep disturbance in other populations, this intervention shows great promise for reducing sleep disturbance and thereby improving related mental and physical health outcomes following the death of a spouse.

PI_NAMEs: CHIRINOS, DIANA ANDREA (contact)

PROGRAM_OFFICER_NAME: CAMPO, REBECCA A

PROJECT_TERMS: Acute;Address;Adherence;Adult;behavior test;Behavior Therapy;behavioral sleep intervention;Bereavement;Biological;Cardiovascular Diseases;cardiovascular disorder risk;Cardiovascular system;career;career development;Cessation of life;Clinical Trials;Cognitive Therapy;Collection;Data;depressive symptoms;Development;Development Plans;Disease;Dropout;efficacy testing;Emotional;Ensure;Environment;Event;Evidence based intervention;Faculty;Feedback;Five-Year Plans;Focus Groups;Funding;Future;Goals;Grant;Grief reaction;improved;improvement on sleep;indexing;Individual;Inflammation;Inflammatory;Institution;Intervention;K-Series Research Career Programs;Knowledge;Longitudinal Studies;Measures;medical schools;Mental Health;Mentors;Methodology;Minority;mortality risk;Myocardial Infarction;Outcome;Participant;physical conditioning;Pittsburgh Sleep Quality Index;Population;Positioning Attribute;post intervention;preference;prevent;primary outcome;psychological distress;Quality of life;Randomized, Controlled Trials;recruit;Research;Research Personnel;Research Project Grants;Residual state;retention rate;secondary outcome;Severities;skills;Sleep;Sleep disturbances;Sleeplessness;Spouses;Stroke;Structure;Surveys;Symptoms;Testing;therapy design;therapy development;Time;Training;Training Activity;United States National Institutes of Health;Universities;Vulnerable Populations;Writing

PROJECT_TITLE: Developing an intervention targeting sleep disturbances among minority bereaved individuals


ORG_CITY: Columbus

ORG_NAME: OHIO STATE UNIVERSITY

PHR: Project Narrative:  Protein receptors are common targets for pharmaceuticals, and improved understanding of the molecular interactions that regulate receptor-ligand interactions in biological systems will facilitate disease treatment. This research will develop instrumentation and methodologies for investigating drug targeting to protein receptors in human cells.

PI_NAMEs: SCHULTZ, ZACHARY  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;Adsorption;Affinity;Amino Acids;antagonist;Binding;Binding Proteins;Biochemistry;Biological;Biological Assay;biological systems;Cells;Chemicals;Complement;Complex;Detection;Disease;drug candidate;drug development;drug efficacy;Drug Screening;Drug Targeting;Environment;experimental study;Failure;Fluorescence Microscopy;Gene Mutation;Goals;Gold;Human;Image;Imaging ligands;improved;insight;instrumentation;Investigation;Ligand Binding;Ligands;Location;metallicity;Metals;Methodology;Methods;Microscopy;Modeling;Molecular;Molecular Conformation;molecular imaging;Monitor;nanoparticle;nanoscale;new technology;novel strategies;Organism;Outcome;particle;Peptides;Pharmaceutical Preparations;Pharmacologic Substance;Phenotype;plasmonics;Property;Proteins;quantum;Raman Spectrum Analysis;receptor;receptor binding;Research;Resolution;response;Scanning;Serum Proteins;side effect;Signal Pathway;Signal Transduction;simulation;Specificity;spectroscopic survey;Surface;System;Techniques;Technology;Therapeutic;tool;ultra high resolution

PROJECT_TITLE: Enhanced Raman Imaging of Ligand-Receptor Recognition


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Brain Disorders;Cerebrovascular;Neurosciences;Rehabilitation;Stroke

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Strokes, which are a leading cause of serious long-term disability, frequently result in the development of compensatory behavioral strategies that can encourage disuse of impaired modalities and contribute to persisting dysfunction. This project will advance understanding of neural mechanisms underlying the influence of compensatory behaviors on persisting disability after stroke and potential strategies for overcoming it, which is significant for informing efforts to optimize and tailor post-stroke interventions.

PI_NAMEs: JONES, THERESA A (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Abbreviations;Address;Affect;Anatomy;Area;arm;Attenuated;Behavior;behavior influence;Behavioral;behavioral outcome;behavioral response;Bilateral;Brain Injuries;Chronic;Compensation;Dendritic Spines;Dependence;Development;disability;Electron Microscopy;Excitatory Synapse;experience;Forelimb;functional disability;Functional disorder;functional improvement;functional outcomes;Goals;Hand;hippocampal pyramidal neuron;Image;imaging approach;Impairment;improved;in vivo;in vivo imaging;Infarction;Ischemia;Knowledge;Learning;Learning Skill;Life;Limb structure;Link;Long term disability;Manuals;Maps;Mediating;microstimulation;Modality;Monitor;Motor;Motor Cortex;Motor Skills;Movement;Mus;Muscimol;Nature;neural;neural patterning;neuromechanism;Paresis;Pathway interactions;Pattern;Performance;post stroke;Prevalence;Proteins;Publishing;Regenerative response;Rehabilitation therapy;Resistance;response;Rodent;Rodent Model;Shapes;Side;skills;skills training;Stroke;stroke intervention;Synapses;Testing;Time;Training;two photon microscopy;Upper Extremity;upper limb hemiparesis;Vertebral column

PROJECT_TITLE: NEURAL MECHANISMS OF COMPENSATING FOR BRAIN DAMAGE

STUDY_SECTION: MFSR

STUDY_SECTION_NAME: Motor Function, Speech and Rehabilitation Study Section[MFSR]