ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_NAME: JESSE BROWN VA MEDICAL CENTER

PHR: Project Narrative: Veterans are at a higher risk of developing thyroid cancer in their lifetime due to the increased potential of radiation exposure in the armed services. Furthermore, veterans who suffered from thyroid cancer self-reported a higher prevalence of Agent Orange exposure, increasing the relevance of this malignancy to the VA population. There is no effective treatment for anaplastic thyroid cancer (ATC). Cancer cell-specific expression of MADD and its ability to act as a pro-survival factor and promote metastasis in ATC makes it an ideal target for therapeutic development. We will test whether MADD depletion can be effective in inhibiting growth and overcoming ATC resistance to various drugs.

PI_NAMEs: PRABHAKAR, BELLUR S (contact)

PROJECT_TERMS: Ablation;Address;advanced disease;agent orange;Aggressive behavior;AKT Signaling Pathway;anaplastic thyroid cancer;Apoptosis;Basement membrane;BAY 54-9085;beta catenin;BRAF gene;cancer cell;Cessation of life;Clinical;Combined Modality Therapy;CRISPR/Cas technology;CTNNB1 gene;Data;Death Domain;Distant;Drug resistance;Drug Targeting;effective therapy;Epithelial Cells;Epithelium;Exhibits;Gene Proteins;glycogen synthase kinase 3 beta;Growth;High Prevalence;high risk;Hyperactivity;In Vitro;in vivo;in vivo evaluation;Incidence;inhibitor;kinase inhibitor;knock-down;knockout gene;Malignant neoplasm of thyroid;Malignant Neoplasms;MAP Kinase Gene;Mediating;Mesenchymal;Metastatic Neoplasm to the Lung;migration;Mitogen-Activated Protein Kinases;mouse model;Mus;Mutation;Nature;Neoplasm Metastasis;Nodal;Normal Cell;novel;novel therapeutics;Oncogenes;Operative Surgical Procedures;Palliative Care;Pathway interactions;patient population;Patient Self-Report;Patients;Pharmaceutical Preparations;Phenotype;Phosphorylation;PIK3CG gene;Population;prevent;Prognosis;protein expression;protein function;Proteins;Proto-Oncogene Proteins c-akt;PTEN gene;Publishing;Radiation exposure;Radioactive Iodine;Resistance;Role;Services;Signal Pathway;Signal Transduction;Site;Small Interfering RNA;standard care;stemness;targeted treatment;Testing;therapeutic development;therapeutic target;therapy resistant;TNF gene;Treatment Efficacy;treatment strategy;tumor;tumor growth;Tumor Suppressor Proteins;Tumor Tissue;Ubiquitination;Undifferentiated;United States;Veterans;WNT Signaling Pathway

PROJECT_TITLE: Co-targeting MADD and Wnt/β-catenin signaling in Anaplastic Thyroid Cancer


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Cardiovascular;Genetics;Heart Disease

ORG_CITY: CHAPEL HILL

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PHYSIOLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE  A hallmark of cardiac diseases is mis-regulated RNA processing. This project seeks to understand how RNA processing of CLTC, a molecule that controls protein trafficking and cell structure, contributes to the function of the heart. The insights gained from this research will be fundamental to our knowledge of cardiac physiology and lay the foundation for identifying future therapeutic targets of cardiac diseases.

PI_NAMEs: GENTILE, GABRIELLE MARIE (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: 5'-AMP-activated protein kinase;Actins;Affinity;Alternative Splicing;Animals;aorta constriction;Architecture;Atrial Natriuretic Factor;Attenuated;Binding;Binding Proteins;Biological;Biological Assay;Biology;Brain;Cardiac;Cardiac Myocytes;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular Physiology;Cardiovascular system;career;cell growth;Cell membrane;Cell Physiology;Cells;Cellular Structures;Clathrin;Clathrin Heavy Chains;Clustered Regularly Interspaced Short Palindromic Repeats;Communities;Confocal Microscopy;Consensus;Cytoskeletal Modeling;Cytoskeleton;Deceleration;Development;Education;EFRAC;Endocytosis;Equilibrium;Event;Exhibits;Exons;experience;experimental study;Faculty;Fellowship;Foundations;Future;Gene Expression Regulation;Generations;Genes;Genetic;Goals;Growth;Heart;Heart Diseases;Heart failure;heart function;Human;Hypertrophy;In Vitro;in vivo;insight;knock-down;Mediating;Membrane;Mentors;Microtubules;Molecular;mouse model;mRNA Precursor;multidisciplinary;Mus;Muscle Fibers;Natriuretic Peptides;North Carolina;Operative Surgical Procedures;Output;overexpression;Pattern;Peptide Receptor;Personal Growth;Phosphorylation;Phosphotransferases;Physiological;Physiology;Play;Polypyrimidine Tract-Binding Protein;Post-Transcriptional RNA Processing;pressure;prevent;programs;Protein Biosynthesis;protein function;Protein Isoforms;protein protein interaction;protein transport;Proteins;Proteome;Proteomics;reconstitution;recruit;Regulation;Report (document);Reporter;Research;Research Personnel;Research Proposals;response;RNA;RNA Processing;RNA Splicing;RNA-Binding Proteins;Role;Scientist;Shortening Fraction;Signal Pathway;Signal Transduction;Site-Directed Mutagenesis;Skeletal Muscle;Spliced Genes;Stress;success;Survival Rate;therapeutic target;Tissues;trafficking;Training;Trans-Activators;Transcript;Universities;Western Blotting;Wild Type Mouse

PROJECT_TITLE: Alternative splicing regulation of CLTC in the heart


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Cancer;Brain Disorders;Cancer;Clinical Research;Data Science;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

ORG_STATE: FL

PHR: PROJECT NARRATIVE Glioblastoma is the most common primary brain cancer worldwide, and urgent treatment strategies are needed since it is almost a universally fatal disease. The focus of this project is to address unmet needs by developing tools that identify and monitor patients with significant anatomic and/or physiologic tumor changes much earlier than current methods, so that in the future, prompt, aggressive, and early therapy adaption can be implemented. This project will translate directly to the practice of clinical medicine and advance the field of glioblastoma treatment.

PI_NAMEs: CULLISON, KAYLIE  (contact)

PROGRAM_OFFICER_NAME: BIAN, YANSONG

PROJECT_TERMS: 3-Dimensional;Address;Aftercare;Age;aggressive therapy;anatomic imaging;Anatomy;automated segmentation;Biopsy;Blood specimen;Brain imaging;brain volume;career;Cessation of life;chemotherapy;Chemotherapy and/or radiation;Clinical;Clinical Medicine;clinical practice;convolutional neural network;Data;Data Set;deep learning;Detection;Diffusion;disability;Disease;Disease Progression;Early treatment;Edema;Evolution;Excision;feature selection;Frustration;Future;Glioblastoma;Goals;Habitats;Image;image processing;imaging biomarker;Immune system;improved;improved outcome;Inflammation;Intervention;Laboratories;learning network;Machine Learning;Magnetic Resonance Imaging;Malignant neoplasm of brain;Manuals;Maps;Medial;Methods;Modification;Molecular;molecular marker;Monitor;Necrosis;Neoplasm Circulating Cells;neovascularization;Neuroanatomy;neuroimaging;novel;novel strategies;Oncology;Operative Surgical Procedures;Patient Monitoring;Patient-Focused Outcomes;Patients;Performance;Performance Status;Perfusion;Physicians;Physiological;Population;predictive modeling;Process;Prognosis;prognostic;Protocols documentation;quantitative imaging;Radiation Oncology;Radiation therapy;radiomics;Research;Resolution;risk stratification;Scanning;Scientist;segmentation algorithm;serial imaging;skills;standard care;Statistical Data Interpretation;Surgically-Created Resection Cavity;System;Techniques;Texture;tool;Training;Translating;Treatment outcome;treatment response;treatment strategy;tumor;tumor growth;Tumor Volume

PROJECT_TITLE: Machine Learning and Radiomics Techniques for Analysis of Daily MRI in Glioblastoma Patients


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Chronic Obstructive Pulmonary Disease;Coronaviruses;Coronaviruses Diagnostics and Prognostics;Coronaviruses Therapeutics and Interventions;Emerging Infectious Diseases;Infectious Diseases;Lung;Prevention

ORG_CITY: DETROIT

ORG_DEPT: CHEMISTRY

ORG_NAME: WAYNE STATE UNIVERSITY

ORG_STATE: MI

PHR: Project Narrative (3-sentence limit) We propose to use next-generation laser-diode arrays to investigate the limits of production technology for hyperpolarized xenon-129, an emerging new FDA-approved imaging modality for functional pulmonary imaging. Specifically, an ultra-frequency-narrowed 180 W laser will be employed to map the hyperpolarized xenon-129 production efficiency, with the vision that recent gains in frequency narrowing can enable efficient contrast agent production with vastly reduced laser power and milder conditions. If successful, this research will substantially improve clinical access to this new MRI contrast agent for functional pulmonary imaging.

PI_NAMEs: CHEKMENEV, EDUARD  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: 2019-nCoV;3-Dimensional;absorption;access restrictions;Affect;Alveolar;Alveolus;Asthma;Biomedical Engineering;Biomedical Technology;Bronchiolitis;cancer imaging;Cells;Cessation of life;Chronic Obstructive Pulmonary Disease;Clinical;clinical imaging;clinical translation;commercialization;Communities;Compensation;Complex;Contrast Media;cost;COVID-19 pandemic;Data;density;design;Development;Devices;Diagnosis;Diffusion;Disease;Disease Outbreaks;Early Diagnosis;Effectiveness;electronic cigarette use;Equipment;Face;Failure;FDA approved;Frequencies;frontier;Functional Magnetic Resonance Imaging;Future;Gases;Generations;Goals;Grant;Image;imaging modality;Imaging Techniques;Imaging technology;Improve Access;improved;innovation;insight;instrumentation;Lasers;Light;Long COVID;Lung;Lung Diseases;lung imaging;lung injury;magnetic field;Magnetic Resonance Imaging;Mammography;Maps;Modeling;models and simulation;Modernization;Monitor;Morbidity - disease rate;mortality;nanometer;next generation;Nuclear;Optics;Outcome;Output;Pathology;Performance;Perfusion;Persons;Pneumonia;Positron-Emission Tomography;power consumption;Process;Production;Pulmonary Fibrosis;pulmonary function;Pulmonology;Pump;Reporting;Research;Resolution;Safety;Signal Transduction;Site;structural imaging;System;Techniques;technological innovation;Technology;Temperature;Thoracic Radiography;Three-Dimensional Imaging;Time;Tissues;treatment response;tumor;ultrasound;vaping;ventilation;virtual;Vision;wasting;Work;X-Ray Computed Tomography;Xenon

PROJECT_TITLE: Next-generation Lasers for Enabling Ultrafast Functional Pulmonary MRI

STUDY_SECTION: IPCA

STUDY_SECTION_NAME: Imaging Probes and Contrast Agents Study Section[IPCA]


ADMINISTERING_IC: DA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

ORG_CITY: NEW HAVEN

ORG_DEPT: PSYCHIATRY

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE – Project 2 (Sofuoglu) The Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) will examine how ingredients in tobacco products, including nicotine and chemicals that produce cooling and sweetness, contribute to product initiation, continued use, and addiction. Project 2 will determine if thresholds for nicotine reinforcement, discrimination, and subjective reward are altered by nicotine dependence and exposure to sweeteners.

PI_NAMEs: KRISHNAN-SARIN, SUCHITRA  (contact);O'MALLEY, STEPHANIE S

PROGRAM_OFFICER_NAME: KIMMEL, HEATHER L

PROJECT_TERMS: addiction;Administrative Supplement;Benchmarking;Budgets;Chemicals;cost;Discrimination;Dose;Electronic cigarette;Individual;Infusion procedures;Inhalation;Interruption;Intravenous;Nicotine;Nicotine Dependence;nicotine exposure;Pharmacy facility;Psychological reinforcement;Research;Rewards;Risk;Science;Smoke;Smoker;Sterility;Sweetening Agents;tobacco products;Tobacco use;Vial device

PROJECT_TITLE: Yale Center for the Study of Tobacco Product Use and Addiction (YCSTP) Project 2: Addictive Threshold of Nicotine and the Impact of Sweeteners

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: NS

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Stroke;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: BIRMINGHAM

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: PROJECT NARRATIVE Even before the COVID-19 pandemic, stroke morality began increasing as did dementia incidence, high blood pressure and diabetes. This was in part driven by racial disparities in these conditions as Black Americans have experienced persistent and increasing risk of stroke, hypertension, diabetes and dementia compared with White Americans. This application will identify reasons for increases in shared risk factors between stroke and dementia (hypertension and diabetes) and the widening racial disparity in stroke mortality and dementia incidence in a 20,000 person population based cohort residing across the lower 48 United States.

PI_NAMEs: CUSHMAN, MARY ;HOWARD, GEORGE ;HOWARD, VIRGINIA J.;JUDD, SUZANNE E (contact);MANLY, JENNIFER JAIE

PROGRAM_OFFICER_NAME: HOMMER, REBECCA EVE

PROJECT_TERMS: Address;Adult;Affect;Age;age group;aged;aging population;Alzheimer's disease related dementia;American;Amyloid;Amyloid beta-Protein;Automobile Driving;baby boomer;Biological Markers;Black American;Black race;black/white disparity;Blood Pressure;blood-based biomarker;brain health;Brain Injuries;cardiovascular disorder prevention;cardiovascular disorder risk;caucasian American;Cognition;Cognitive;cognitive function;cognitive testing;cohort;Cohort Effect;Communication;Communities;COVID-19;COVID-19 pandemic;Data;Dementia;dementia risk;Developed Countries;Diabetes Mellitus;Diet;Disparity;Epidemiology;experience;follow-up;Funding;Future;General Population;Generations;geographic difference;Geography;Glial Fibrillary Acidic Protein;Health;health disparity;Heart Diseases;Hispanic;Home;Home visitation;Hypertension;Impaired cognition;improved;Incidence;Income;Individual;Infrastructure;interest;Interview;Life Expectancy;Light;Lipoprotein (a);Mentors;middle age;Morality;mortality;Neurocognitive;neurofilament;Not Hispanic or Latino;novel;Obesity;Outcome;Participant;participant enrollment;patient engagement;Patient Recruitments;Persons;Pharmaceutical Preparations;Play;population based;Prevalence;Publications;racial difference;racial disparity;recruit;repository;Research;Research Personnel;Resources;retention rate;Risk Factors;risk sharing;Role;Scientist;social health determinants;social structure;Stroke;Stroke Belt;stroke incidence;stroke risk;Structure;trend;United States;Vascular Cognitive Impairment;Visit

PROJECT_TITLE: Understanding Cohort Effects on Stroke, VCID, and Cognition After Major Epidemiologic Transitions

STUDY_SECTION: AIMR

STUDY_SECTION_NAME:
Aging, Injury, Musculoskeletal, and Rheumatologic Disorders Study
Section[AIMR]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurodegenerative;Neurosciences;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: CHICAGO

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Alzheimer's disease and related dementias (ADRD) disproportionately affect Black and Hispanic adults, attributable, in part, to disparities in socioeconomic status and age-related health conditions. Only by identifying risk factors contributing to these disparities can we address them. Mass incarceration, which disproportionately affects Black and Hispanic people, may play a key role. This is the first comprehensive study to investigate how the dose of incarceration—frequency and duration of stays, type of facility (juvenile, jail, prison), age(s), and recency—affects overall health, age-related conditions, and risk factors for ADRD.

PI_NAMEs: TEPLIN, LINDA A (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: access restrictions;Address;Adolescence;Adolescent;Adult;adverse childhood events;Affect;Age;age related;aged;Agreement;Alcohol abuse;Alzheimer's disease related dementia;Alzheimer's disease risk;Biological Aging;Black Populations;Black race;Blood Pressure;blood-based biomarker;Characteristics;Cognition;Cognitive;Communities;critical developmental period;Crystallization;Data;Data Set;dementia risk;design;Development;Diabetes Mellitus;Disease;Disparity;disparity reduction;Dose;Economics;Education;Environmental Risk Factor;ethnic difference;ethnic diversity;Exercise;experience;feasibility testing;Foundations;Frequencies;Funding;General Population;glucose metabolism;Health;health assessment;health care availability;health disparity;healthy aging;healthy lifestyle;Heart Rate;Height;Hispanic;Hispanic Populations;housing instability;Hypertension;Impaired cognition;Imprisonment;indexing;Individual;Inflammation;Intelligence;Interview;Jail;Lipids;Liquid substance;Longitudinal cohort study;Longitudinal Studies;Longitudinal Surveys;Measurement;Memory;Mental Depression;Mental Health;Methods;middle age;Modeling;modifiable risk;National Longitudinal Survey of Adolescent to Adult Health;Neighborhoods;Obesity;Occupations;Outcome;Participant;participant interview;Persons;Phase;Physical assessment;physical conditioning;Physiological;Pilot Projects;Play;Population;Prevention;Prisons;Prospective Studies;protective factors;Public Health;Public Housing;racial difference;racial diversity;Recommendation;Recontacts;Recording of previous events;Renal function;Reporting;response;Rest;Risk;Risk Factors;risk mitigation;Safety;Sampling;Sex Differences;Smoking;social;social contact;social health determinants;Social support;sociodemographics;Socioeconomic Status;Stress;Time;Trauma;United States National Institutes of Health;waist circumference;Weight;Well in self

PROJECT_TITLE: Consequences of Incarceration on Health, Age-Related Conditions, and Risk Factors for ADRD

STUDY_SECTION: CIHB

STUDY_SECTION_NAME: Community Influences on Health Behavior Study Section[CIHB]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Childhood Obesity;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Obesity;Pediatric;Physical Activity;Prevention;Racial and Ethnic Minority Health Research

ORG_DEPT: PEDIATRICS

PHR: PROJECT NARRATIVE South Asian American adults are known to have elevated risks of obesity and physical inactivity. These elevated risks may be observed in South Asian American youth. This project aims to evaluate physical activity behavior and obesity among South Asian American children and to understand how cultural factors are related to child physical activity in South Asian American families.

PI_NAMEs: KWON, SOYANG  (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: 16 year old;Acceleration;Accelerometer;Acculturation;actigraphy;Address;Adoption;Adult;Affect;aged;analytical method;Area;Asian;Asian Americans;Asian Indian;Asian Women;Attitude;Behavior;Black race;Body Composition;Body fat;Body mass index;British;caucasian American;Chicago;Child;Child Rearing;Chinese;Classification;Clinical Trials;Communities;Conflict (Psychology);cost efficient;Country;Cultural Characteristics;Data;Data Aggregation;Data Analyses;Data Sources;Daughter;design;Devices;Dual-Energy X-Ray Absorptiometry;Equation;Ethnic Population;Evaluation;exercise intervention;Family;Fatty acid glycerol esters;Filipino;fitness;Foundations;Gender;Generations;Goals;Health;Hispanic;Immigrant;Immigrant family;innovation;Knowledge;Low Prevalence;Machine Learning;Maps;Masks;Measures;Methods;Modeling;modifiable behavior;Mothers;muscle strength;National Health and Nutrition Examination Survey;Obesity;obesity prevention;obesity risk;Output;Overweight;Parents;Participant;Patient Self-Report;Physical activity;physical inactivity;Prevalence;Public Health;Questionnaires;racial population;Religion;Research;Research Activity;Risk;Self-Examination;South Asian;Sports;Subgroup;Surveys;therapy design;Thinness;Transportation;United States;Variant;vigorous intensity;Wrist;Youth

PROJECT_TITLE: Physical activity in South Asian Youth

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Health, Behavior, and Context Study Section[CHHD-M]


ADMINISTERING_IC: NR

IC_NAME: NATIONAL INSTITUTE OF NURSING RESEARCH

NIH_SPENDING_CATS: Asthma;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Lung;Pediatric;Social Determinants of Health

ORG_CITY: CINCINNATI

ORG_NAME: CINCINNATI CHILDRENS HOSP MED CTR

ORG_STATE: OH

PHR: Project Narrative Asthma disproportionately impacts youth who have been systematically marginalized. The purpose of this study is to develop and evaluate an Interactive Mobile Asthma Action Plan (IMAAP) to support asthma self- management and adherence to ‘as needed’ rescue medications, which are a critical component of preventing exacerbations. If successful, IMAAP has long-term potential in preventing exacerbations, improving health outcomes, and promoting health equity particularly for adolescents with asthma from marginalized populations.

PI_NAMEs: RAMSEY, RACHELLE R. (contact)

PROGRAM_OFFICER_NAME: HUSS, KAREN

PROJECT_TERMS: Adherence;Adolescent;Affect;Age;Algorithms;Asthma;asthma exacerbation;Behavior;behavior prediction;Behavior Therapy;Bronchodilator Agents;Caregivers;Caring;Childhood;Chronic Disease;Clinic;clinical predictors;comparison control;Development;Development Plans;digital;digital health;Discrimination;disparity reduction;Economics;Education;efficacy testing;Electronics;Emergency department visit;empowerment;Enrollment;Ensure;Equity;Ethnic Origin;Evaluation;experience;falls;Family;Feedback;Future;Goals;Guidelines;Health;health care availability;health care service utilization;health communication;health equity;health equity promotion;Health Personnel;Health Services Accessibility;Health Technology;Healthcare;Home;Hospitalization;Improve Access;improved;Individual;innovation;Instruction;International;Interview;Knowledge;lens;Life;Maps;marginalization;marginalized population;Measures;medication compliance;Mission;Mobile Health Application;Modeling;Monitor;Morbidity - disease rate;mortality;Outcome;Participant;patient safety;Patients;Pharmaceutical Preparations;Phase;Physicians;preference;prevent;primary outcome;Process;prototype;Provider;pulmonary function;Quality of Care;Race;racial discrimination;racism;Randomized, Controlled Trials;Recommendation;Reporting;Research;Sampling;secondary outcome;Self Management;social health determinants;Social support;socioeconomic disparity;Spirometry;Strategic Planning;Symptoms;Technology;Testing;Time;tool;treatment as usual;treatment planning;usability;Work;Writing;Youth

PROJECT_TITLE: IMAAP: Development and evaluation of an Interactive Mobile Asthma Action Plan

STUDY_SECTION: CMGC

STUDY_SECTION_NAME: Clinical Management in General Care Settings Study Section[CMGC]


ADMINISTERING_IC: DK

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Chronic Liver Disease and Cirrhosis;Digestive Diseases;Hematology;Hepatitis;Liver Disease

ORG_CITY: BOSTON

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Liver fibrosis is a serious health problem, which often progresses to cirrhosis and liver cancer, together accounting for approximately 2 million deaths per year worldwide. New insights into the pathogenesis of liver fibrosis in hemochromatosis and other liver disorders are needed to design novel therapeutic strategies.

PI_NAMEs: XIAO, XIA  (contact)

PROGRAM_OFFICER_NAME: SASLOWSKY, DAVID E

PROJECT_TERMS: Ablation;Accounting;Alcoholic Liver Diseases;Biological;BMP5 gene;Bone Morphogenetic Proteins;career;cell type;Cells;Cellular biology;Cessation of life;Chronic Hepatitis C;chronic liver disease;Circulation;Cirrhosis;Clinical Treatment;Coculture Techniques;Collagen;conditional knockout;Data;Dependence;design;Diet;DNA Sequence Alteration;Event;extracellular;Faculty;fibrogenesis;Fibrosis;Foundations;Genes;Genetic Transcription;Goals;Health;Hemochromatosis;Hepatic Stellate Cell;Hepatitis C;Hepatocyte;hepcidin;HFE2 gene;Histopathology;Homeostasis;Hormones;Hospitals;Human;In Vitro;in vivo;insight;intercellular communication;Iron;Iron Metabolism Disorders;Iron Overload;Knockout Mice;Knowledge;Ligands;Liver;Liver Cirrhosis;liver development;Liver diseases;Liver Fibrosis;liver injury;MADH2 gene;MADH3 gene;MADH7 gene;Malignant neoplasm of liver;Mediating;Mediator;metal transporting protein 1;Modeling;Molecular;Morbidity - disease rate;mortality;Mus;Myofibroblast;non-alcoholic fatty liver disease;nonalcoholic steatohepatitis;novel;novel therapeutic intervention;osteogenin;paracrine;Pathogenesis;Pathology;Pathway interactions;Patients;Phosphorylation;Play;Positioning Attribute;Production;Proteomics;Reporting;Research;Research Institute;Role;Signal Pathway;Signal Transduction;Signaling Protein;skills;Smad1 Protein;System;Techniques;tenure track;Testing;TFR2 gene;Training;training opportunity;transcriptome sequencing;transdifferentiation;Transforming Growth Factor beta;Transforming Growth Factors;WNT Signaling Pathway

PROJECT_TITLE: Role of SMAD1/5/8 signaling in liver fibrosis

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Digestive Diseases and Nutrition C Study Section[DDK-C]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: NEUROSCIENCES

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PUBLIC HEALTH RELEVANCE Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease with no available therapies. We propose to determine the mechanisms through which mATXN1 induces dysfunction of cerebellar astrocytes and the precise impact of such dysfunction on disease outcomes to render deeper understanding of cerebellar physiology, SCA1 pathogenesis and possible targets for therapies.

PI_NAMEs: CVETANOVIC, MARIJA  (contact)

PROGRAM_OFFICER_NAME: RANGANATHAN, SRIKANTH

PROJECT_TERMS: Address;Affect;Astrocytes;astrogliosis;ataxin-1;Behavioral;Brain;brain cell;CAG repeat;Calcium;Calcium Signaling;Cell Communication;Cell Physiology;cell type;Cerebellar Diseases;Cerebellum;Clinical;Code;Confocal Microscopy;Data;Disease;Disease Outcome;Disease Progression;effective therapy;Equilibrium;Fiber;Frequencies;Functional disorder;Gene Expression;Genes;Genetic Recombination;Genetic Transcription;Gliosis;Glutamine;Goals;Human;Image;Immunofluorescence Immunologic;In Vitro;in vivo;Inherited;Knock-in Mouse;Knowledge;Molecular;Motor;motor deficit;mouse genetics;mouse model;Movement;Mus;mutant;Nerve Degeneration;Neurodegenerative Disorders;Neuroglia;Neuronal Dysfunction;Neurons;novel;Onset of illness;Pathogenesis;Pathologic;Pathology;Pathway interactions;Patients;Photometry;Physiology;Play;protein expression;public health relevance;Purkinje Cells;Research;Role;single nucleus RNA-sequencing;Site;Slice;Symptoms;targeted treatment;Testing;Type 1 Spinocerebellar Ataxia;Walking

PROJECT_TITLE: Astrocyte dysfunction in Spinocerebellar ataxia type 1 (SCA1)

STUDY_SECTION: CDIN

STUDY_SECTION_NAME: Chronic Dysfunction and Integrative Neurodegeneration Study Section[CDIN]


NIH_SPENDING_CATS: Autoimmune Disease;Biomedical Imaging;Cardiovascular;Clinical Research;Prevention;Rare Diseases;Scleroderma

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

PHR: PROJECT NARRATIVE We present here a novel magnetic resonance imaging (MRI) based imaging approach for a comprehensive quantitative assessment of vasculopathy, tissue hypoxia, and fibrosis in the hands of patients with scleroderma. The short-term goal of this project is to identify effective imaging biomarkers to guide prevention and to monitor effectiveness of therapy for digital ulcers in patients with scleroderma. The potential future implication of this study is the development of peripheral vascular imaging tools that could be applied to patients with other autoimmune rheumatic disease conditions or peripheral artery disease.

PI_NAMEs: FEHER, ATTILA  (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TERMS: Adaptive Immune System;Amputation;analog;Animal Model;Arteries;Autoimmune Diseases;autoimmune rheumatologic disease;Award;Biological Markers;blood oxygen level dependent;Blood Vessels;Brain Hypoxia-Ischemia;Cardiovascular Diseases;cardiovascular imaging;career development;Case Fatality Rates;Categories;Cause of Death;Chronic;Classification;Clinical;Clinical Assessment Tool;Clinical assessments;Clinical Trials;Coagulation Process;cohort;Complement;Complex;Complication;Consent;coronary fibrosis;Data;Development;Diffuse;digital;digital treatment;disability;Disease;Effectiveness;Endothelium;Epoprostenol;Evaluation;Event;experience;extracellular;Fibroblasts;Fibrosis;Fingers;follow-up;Frequencies;Fright;Functional disorder;Future;Goals;Guide prevention;Hand;Hand's disease;healing;heart imaging;High Prevalence;high risk;Hypoxia;Image;Image Analysis;imaging approach;imaging biomarker;Imaging Device;imaging modality;Impairment;improved;indexing;Infusion procedures;Injury;instrument;Intervention;Intravenous;intravenous administration;Ischemia;Limb structure;Lower Extremity;Machine Learning;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;Maps;Measures;Mediator;Mentors;Mentorship;Methodology;Microscopic Angioscopy;Monitor;Morbidity - disease rate;non-invasive imaging;novel;Outcome;Outpatients;Pathogenesis;Patient Outcomes Assessments;Patients;Perfusion;Peripheral;Peripheral arterial disease;Peripheral Vascular Diseases;Physiological;Pilot Projects;prevent;Prevention;Process;Prospective Studies;Prostaglandins I;quantitative imaging;Raynaud Disease;Relaxation;Reporting;Research;Research Personnel;Resolution;response;Rheumatism;Rheumatoid Arthritis;Role;Scleroderma;Secondary to;Severities;Skeletal Muscle;skills;Skin;skin fibrosis;Symptoms;System;Systemic Lupus Erythematosus;Systemic Scleroderma;Techniques;Testing;Time;Tissues;tool;Training;Ulcer;United States;Vascular Diseases;Vasodilation;Work

PROJECT_TITLE: Evaluation of digital ischemia in scleroderma with multiparametric MRI

STUDY_SECTION: MPOR

STUDY_SECTION_NAME: NHLBI Mentored Patient-Oriented Research Study Section[MPOR (MA)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Hypertension;Rare Diseases

PHR: PROJECT NARRATIVE Around 50% of infants born extremely preterm develop a chronic lung disease known as bronchopulmonary dysplasia of which some infants will also develop pulmonary hypertension of which 50% of children will die before the age of 2. Physicians are currently limited in their (1) ability to predict which infants will develop this more severe form and (2) ability to select the most appropriate therapy that will improve outcomes in infants with this condition. This proposal will develop a tool to predict which infants are more likely to develop bronchopulmonary dysplasia and pulmonary hypertension, will examine whether currently used therapies for this disease improve infants’ condition, and determine whether using different amounts of oxygen improve outcomes in infants with this disease.

PI_NAMEs: GENTLE, SAMUEL J (contact)

PROGRAM_OFFICER_NAME: PILEGGI, ANTONELLO

PROJECT_TERMS: 2 year old;Address;Adult;adverse outcome;Advisory Committees;Age;American;American Heart Association;Animal Model;Award;Biometry;Bronchopulmonary Dysplasia;Cardiovascular system;career;Caring;Characteristics;Chest;Child;Child Care;Chronic lung disease;Classification;Clinical;Consensus;Cross-Over Studies;Cross-Over Trials;Data;Data Analyses;design;Development;Disease;Doctor of Philosophy;Early Diagnosis;Early identification;Echocardiography;evidence base;Expectancy;experience;Exposure to;extreme prematurity;Frequencies;Funding;Future;Goals;Guidelines;Health Care Costs;Heart Diseases;high risk;Hypoxemia;Image Analysis;improved;improved outcome;Individual;Infant;inhaled nitric oxide;innovation;insight;Intervention;Investigation;Knowledge;Lead;Lung;Lung Diseases;Master of Science;Medical;Mentored Patient-Oriented Research Career Development Award;Mentorship;Mission;model development;Modeling;Morbidity - disease rate;mortality;mortality risk;Multi-Institutional Clinical Trial;National Heart, Lung, and Blood Institute;novel;Outcome;Oxygen;Oxygen Therapy Care;patient subsets;Patients;Pharmacotherapy;Physicians;Pre-Clinical Model;Precision therapeutics;Premature Infant;prevent;Prevention;Probability;prospective;Public Health;Publications;Pulmonary Hypertension;Randomized;randomized trial;Recommendation;Recording of previous events;Reporting;Research;Research Design;Research Personnel;Retinopathy of Prematurity;Risk;Risk Estimate;Role;Scientist;screening;Signal Transduction;sildenafil;Societies;Survivors;targeted treatment;Therapeutic;Time;tool;Training;treatment response;United States National Institutes of Health;Vasodilator Agents;Vulnerable Populations

PROJECT_TITLE: Therapeutic Strategies for the Management of Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension

STUDY_SECTION_NAME: Pediatrics Study Section[CHHD-A]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Aging;Atherosclerosis;Biotechnology;Cardiovascular;Data Science;Genetics;Heart Disease;Heart Disease - Coronary Heart Disease;Human Genome;Nutrition;Precision Medicine;Prevention;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

ORG_STATE: TX

PHR: Project Narrative This study will provide deep insights into molecular phenotypes and biological pathways that mediate the effects of lifestyle and host risk factors on cardiovascular traits and risk of incident cardiovascular disease. Our findings may contribute to the discovery of novel biomarkers and therapeutic targets for cardiovascular disease, as well as biomarker-based precision prevention for this devastating disease.

PI_NAMEs: WEI, PENG  (contact)

PROGRAM_OFFICER_NAME: YARDEN, RONIT I

PROJECT_TERMS: Age;Alcohol consumption;analysis pipeline;Biological;Biological Markers;Blood Pressure;Body mass index;Cardiovascular Diseases;cardiovascular disorder risk;cardiovascular risk factor;Cardiovascular system;Cessation of life;Cholesterol;cohort;Complex;Coronary heart disease;Data;data resource;Data Set;density;Diastolic blood pressure;Diet;Disease;Disease Outcome;DNA Methylation;Ethnic Origin;fasting glucose;Framingham Heart Study;Gene Expression;genome sequencing;Genotype;Healthcare Systems;Heart Diseases;Hematological Disease;High Density Lipoproteins;high dimensionality;high throughput technology;Hypertension;Individual;individualized prevention;insight;Integration Host Factors;LDL Cholesterol Lipoproteins;Life Style;Low-Density Lipoproteins;Lung Diseases;Measures;Mediating;Mediation;Mediator;men;Mendelian randomization;Meta-Analysis;Methods;Molecular;molecular marker;molecular phenotype;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;Multiomic Data;multiple omics;National Heart, Lung, and Blood Institute;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;novel marker;Outcome;Pathway interactions;Phenotype;phenotypic data;Physical activity;programs;Race;Rare Diseases;Research;response;Risk;Risk Factors;Role;secondary analysis;sex;Site;Smoking;Societies;Statistical Methods;Stroke;stroke event;survival outcome;Time;trait;Trans-Omics for Precision Medicine;Triglycerides;Validation;whole genome;Woman;Women's Health;Work

PROJECT_TITLE: High-dimensional Mediation Analysis of Cardiovascular Traits with Multi-omics Data

STUDY_SECTION: CRD

STUDY_SECTION_NAME: Cardiovascular and Respiratory Diseases Study Section[CRD]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Networking and Information Technology R&D (NITRD);Prevention;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health;Telehealth

ORG_CITY: WINSTON-SALEM

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

PHR: Project Narrative Black Americans suffer the highest toll from hypertension with double the hypertension-related death rate from cardiovascular disease compared with White Americans, requiring urgent, more effective, and equitable hypertension care models. In our analysis, we noted that telemedicine management of hypertension overall is more effective for blood pressure control than usual clinic-based care, but the benefit is significantly diminished in studies that enrolled more Black patients than studies that enrolled more White patients, likely due to a lack of tailoring of the telemedicine intervention to the needs and social context of Black patients. This study proposes to leverage the contextual needs of socially disadvantaged Black patients and the primary care clinics they attend in using the telemedicine intervention to make the intervention responsive to the needs of the patients and clinics and will eventually examine the feasibility of the refined intervention compared with usual clinic-based care in a pilot randomized controlled trial, thus paving a pathway for a future larger study to confirm the benefit of the telemedicine intervention and to advance equity in blood pressure control in socially disadvantaged Black patients.

PI_NAMEs: POKHAREL, YASHASHWI  (contact)

PROGRAM_OFFICER_NAME: REDMOND, NICOLE

PROJECT_TERMS: Address;Age;Area;Award;Black American;black patient;Black race;Blood Pressure;blood pressure control;blood pressure reduction;Cardiovascular Diseases;cardiovascular disorder prevention;Cardiovascular system;career;career development;Career Mobility;Caring;caucasian American;Clinic;Clinic Visits;Clinical;Clinical effectiveness;clinical implementation;Clinical Trials;Clinical Trials Design;Committee Members;Communities;Community Health Aides;comparison intervention;Complement;contextual factors;Data;Death Rate;Dedications;design;diagnostic accuracy;Disparity;disparity reduction;Educational workshop;Enrollment;Environment;epidemiology study;Equity;Evaluation;experience;Exploration, Preparation, Implementation, and Sustainment;Faculty;Failure;Future;Goals;health equity;health inequalities;Health Personnel;Health system;Home;Home Blood Pressure Monitoring;human centered design;Hypertension;hypertension control;implementation framework;implementation research;implementation science;implementation strategy;improved;Inequity;innovation;Internal Medicine;Intervention;intervention refinement;Intervention Trial;Interview;Life;Measurement;Medical;medical schools;member;Mentors;Meta-Analysis;Methods;Modeling;mortality;multidisciplinary;National Heart, Lung, and Blood Institute;Not Hispanic or Latino;Outcomes Research;Pathway interactions;patient oriented research;Patients;Pharmaceutical Preparations;Pharmacotherapy;Physicians;pilot trial;Population;Positioning Attribute;Prevention Research;primary care clinic;Process;programs;prototype;Provider;Random Allocation;Randomized, Controlled Trials;recruit;Research;Research Personnel;Risk Factors;Scientist;Self Care;Self Management;skill acquisition;skills;social;social disparities;Social Environment;social interventions;Social Workers;Standardization;Strategic vision;Surveys;System;Telemedicine;Testing;Therapeutic;Time;Titrations;Training;trial enrollment;Universities;Vulnerable Populations

PROJECT_TITLE: Tailoring a Telemedicine Hypertension Management Intervention for Black Patients


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Machine Learning and Artificial Intelligence;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: SAN ANTONIO

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER

PHR: PROJECT NARRATIVE: While the number of Alzheimer’s disease cases is expected to increase nationally, racial and ethnic minorities are anticipated to bear a disproportionate burden of disease with the largest increase among Hispanics. New neuroimaging technologies have made it possible to study tau, a protein that is strongly linked with Alzheimer’s disease, in the brain, however, the majority of research has been conducted in non- Hispanic white adults. We now propose to extend these investigations to Hispanic older adults and examine factors that may increase the risk of tau build-up in the brain in effort to improve early detection of Alzheimer’s disease and inform the development of interventions relevant to this growing, underserved demographic. 1

PI_NAMEs: GONZALES, MITZI MICHELLE;HABES, MOHAMAD  (contact);TOLEDO ATUCHA, JUAN B

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Acceleration;Adult;Affect;Alzheimer disease detection;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease related dementia;Area;Artificial Intelligence;artificial intelligence method;Attenuated;Binding;Biological Markers;Blood;blood-based biomarker;Brain;burden of illness;cardiovascular risk factor;Caring;cerebrovascular;Cerebrovascular Disorders;Cerebrum;Clinical;clinical translation;Clinical Trials;Cognition;Cognitive;cohort;Communities;comorbidity;Data;data harmonization;Dementia;Deposition;deprivation;Detection;Diagnosis;Diagnostic;diagnostic accuracy;diagnostic screening;Disease;disorder risk;Disparity;Early Diagnosis;ethnic disparity;ethnic diversity;ethnic minority;Ethnic Population;Fostering;health disparity;Heterogeneity;high dimensionality;Hispanic;Hispanic Populations;hyperphosphorylated tau;Image;Impaired cognition;improved;in vivo;indexing;Inequity;insight;interest;Investigation;Link;Longitudinal cohort;Magnetic Resonance;Magnetic Resonance Imaging;Measures;Mediating;Mediation;Mexican Americans;mild cognitive impairment;mixed dementia;Modeling;Monitor;neuroimaging;Not Hispanic or Latino;novel;older adult;Outcome;Pathologic;Pathology;Pathway interactions;Pattern;Plasma;Population;Population Heterogeneity;Positron-Emission Tomography;pre-clinical research;precision medicine;Prevalence;prevent;Proteins;racial minority;racial population;Research;Resources;Risk;risk stratification;Sampling;screening;Shoulder;social health determinants;socioeconomic disparity;South Texas;Stratification;tau Proteins;Technology;therapy development;Tracer;United States;Validation;Visualization;Water;white matter;white matter damage;White Matter Hyperintensity

PROJECT_TITLE: Cerebral tau deposition and comorbid cerebrovascular disease across the Alzheimer's disease continuum in Mexican Americans


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Mental Health;Post-Traumatic Stress Disorder (PTSD);Prevention;Substance Misuse

PHR: Project Narrative The co-occurrence of trauma and substance use is highly clinically relevant; identifying drivers of this co- occurrence will benefit the health of our nation. This project will provide the groundwork for early detection and intervention of substance use by using cutting-edge technologies to identify emotional processes as time- sensitive proximal predictors of substance use in the daily lives of trauma-exposed individuals. The training experiences described in the current application represent a logical extension of Dr. Schick's program of research and will facilitate the acquisition and refinement of advanced research skills necessary to become an independent researcher at the forefront of cutting-edge research in the areas of substance use, emotional processes, and PTSD.

PI_NAMEs: SCHICK, MELISSA R (contact)

PROGRAM_OFFICER_NAME: COLLIER KIDEMU, KEVA WONTORIA

PROJECT_TERMS: Address;Admission activity;Adult;Advanced Development;Alcohol consumption;Applications Grants;Area;Arousal;Autonomic nervous system;Behavior;Biosensor;career;clinically relevant;Communities;Controlled Environment;Data;data collection methodology;design;Development;Disease;Drug usage;Early Diagnosis;Early Intervention;Ecological Bias;Educational Status;emotion dysregulation;emotion regulation;Emotional;Emotions;Ensure;Environment;evidence base;experience;Functional impairment;Funding;Goals;Health Benefit;Health Priorities;heart rate variability;heuristics;indexing;Individual;innovation;Interdisciplinary Study;Intervention;Knowledge;Lead;Link;Measures;medical schools;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Methodology;Methods;mobile computing;Modeling;National Institute of Drug Abuse;Nature;Nervous System Physiology;Outcome;Participant;Patient Self-Report;Pattern;Persons;Physiological;Physiology;Post-Traumatic Stress Disorders;Postdoctoral Fellow;Predictive Factor;Prevention program;Prevention Research;Process;Productivity;programs;Psychiatry;Psychophysiology;Qualifying;reduced substance use;Reporting;Research;Research Design;Research Personnel;Resources;Risk;Role;Sampling;Severities;skill acquisition;skills;Specificity;substance use;Substance Use Disorder;substance use prevention;Surveys;Symptoms;Technology;Testing;therapy development;Time;tool;Training;Trauma;trauma exposure;traumatic event;treatment program;Undifferentiated;wearable sensor technology;Work

PROJECT_TITLE: Leveraging Mobile Technology to Explicate the Role of Emotions in Substance Use Among Trauma-Exposed Community Adults

STUDY_SECTION: MESH

STUDY_SECTION_NAME: Biobehavioral Mechanisms of Emotion, Stress and Health Study Section[MESH]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Mental Health;Microbiome;Neurodegenerative;Neurosciences;Physical Activity;Prevention;Women's Health Research

ORG_DEPT: SOCIAL SCIENCES

ORG_NAME: HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) are a leading cause of death. Based on prior work finding optimism is related to longevity and health in aging, this project will extensively examine if optimism is associated with less cognitive decline over time and potential mechanisms explaining the relationship. This research can help identify new targets for interventions to improve cognitive health and reduce risk of ADRD.

PI_NAMEs: GRODSTEIN, FRANCINE ;KUBZANSKY, LAURA D (contact)

PROGRAM_OFFICER_NAME: HOOKER, EMILY DIANE

PROJECT_TERMS: Accelerometer;Adult;African American population;Age;Aging;aging related disease;Alzheimer's disease related dementia;Behavioral;Biological;Calibration;caucasian American;Cause of Death;Cellular Phone;Chronic Disease;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive testing;cohort;Data;Data Collection;data harmonization;Dementia;design;Disease;Ensure;Environment;Epigenetic age;Episodic memory;Feces;Frequencies;gut microbiome;gut microbiota;gut-brain axis;Health;Health and Retirement Study;Health behavior;healthspan;healthy aging;high risk;human old age (65+);Impaired cognition;improved;insight;Intervention;Jackson Heart Study;life span;Link;Longevity;Measurement;Measures;Mediating;Mediator;Memory;men;Metagenomics;Methods;microbiota composition;middle age;mobile application;mobile computing;Molecular;mortality;Multi-Ethnic Study of Atherosclerosis;novel;Nurses' Health Study;optimism;Outcome;Participant;Pathway interactions;Patient Self-Report;Physical activity;Population;Population Heterogeneity;prevent;Prevention;promote resilience;prospective;Protocols documentation;psychologic;Psychological Factors;Race;racial diversity;racial population;Research;resilience;Risk;Risk Reduction;Role;Sampling;Science;sex;Telomere Shortening;Testing;Time;Woman;Women's Health;Work

PROJECT_TITLE: Optimism and Dementia-Related Health Outcomes

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Cancer;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Ovarian Cancer;Racial and Ethnic Minority Health Research;Rare Diseases;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: DUKE UNIVERSITY

PHR: NARRATIVE For ovarian cancer, the most deadly gynecological cancer, racial and ethnic disparities in outcomes are pervasive with a potential underlying role for biological impacts of social disadvantage. The vaginal microbiome may play such a role through its capacity to produce metabolites that shape the tumor microenvironment and its dependence on host factors such as race and ethnicity and poverty. The proposed study will enrich scientific knowledge on the functional implications of racial and ethnic differences in vaginal fluid metabolites, provide public health value by identifying potential prognostic biomarkers for ovarian cancer, and inform the design of therapeutic interventions that involve the modulation of vaginal microbiome to reduce inflammation.

PI_NAMEs: OSAZUWA-PETERS, OYOMOARE L (contact)

PROGRAM_OFFICER_NAME: HUSSAIN, SHADAB FATIMA

PROJECT_TERMS: Address;Antineoplastic Agents;Award;Behavior;Biological;Biological Factors;black patient;Black race;black women;cancer epidemiology;cancer health disparity;Cancer Patient;cancer recurrence;Cancer Survivor;carcinogenicity;career;cervicovaginal;Chronic;Clinical;Dependence;design;Diagnosis;disorder risk;Disparity;Epidemiologist;Epithelium;ethnic difference;ethnic disparity;Ethnic Origin;experience;Female;Funding;Future;Gene Expression;Guidelines;health care availability;health disparities in women;health disparity;health inequalities;Hispanic;Hispanic Women;Human;Immune response;Incidence;indexing;Individual;Inflammation;Inflammatory;Integration Host Factors;Intervention;Investigation;Knowledge;Lactobacillus;Lipopolysaccharides;Liquid substance;Malignant Female Reproductive System Neoplasm;Malignant neoplasm of ovary;Malignant Neoplasms;Measures;Metabolic;metabolic profile;metabolomics;microbiome composition;microbiota;microbiota transplantation;Molecular;Molecular Epidemiology of Cancer;mortality;Neighborhoods;Not Hispanic or Latino;Outcome;Pathogenesis;Pathogenicity;Pathway interactions;Patients;Pattern;Physiology;Play;Population;Poverty;Production;Prognostic Marker;prognostic value;Public Health;Race;racial difference;racial disparity;recruit;Recurrence;Resources;Risk Factors;Role;Serous;Shapes;skills;social;Social Adjustment;social disparities;Social Environment;social factors;social health determinants;social influence;Socioeconomic Status;Survival Rate;Testing;theories;Therapeutic Intervention;Training;treatment response;Tryptophan;tumor;tumor microenvironment;tumor progression;tumorigenesis;vaginal fluid;vaginal microbiome;vaginal microbiota;Variant;White Women

PROJECT_TITLE: Elucidating racial and ethnic differences in functional effects of the vaginal microbiome in ovarian cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


NIH_SPENDING_CATS: Childhood Injury;Clinical Research;Conditions Affecting the Embryonic and Fetal Periods;Genetics;Infant Mortality;Infectious Diseases;Lung;Neonatal Respiratory Distress;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Pulmonary Hypertension;Rare Diseases

PHR: PROJECT NARRATIVE Chorioamnionitis, or in-utero inflammation is the most common cause of preterm birth and increases the risk for neonatal mortality and Bronchopulmonary dysplasia, a chronic lung disease with debilitating outcomes. This proposal is relevant to public health because it aims to establish that chorioamnionitis causes the development of bronchopulmonary dysplasia by altering the immune responses of the developing lung. Completion of this proposal will provide insight into how in-utero inflammation affects lung development, and characterize therapeutic targets, addressing the goals of the NIH to seek a mechanistic understanding of the developmental immunobiology of lung diseases in early life and reduce the incidence of chronic lung disease.

PI_NAMEs: JAIN, VIRAL G (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TERMS: Address;Adult;adverse outcome;Affect;aspirate;Back;Bioinformatics;Biology;Birth;Blood;Brain Injuries;Bronchopulmonary Dysplasia;Cells;Chronic lung disease;cytokine;Data;Development;Disease;Echocardiography;effective therapy;Eligibility Determination;Epigenetic Process;epigenomics;experimental study;exposed human population;Exposure to;extreme prematurity;fetal;Fetal Mortality Statistics;Functional disorder;Generations;Genes;Gestational Age;Goals;Harvest;heart function;high risk;Histology;Human;IL17 gene;Immune;immune function;Immune response;Immune system;Immunobiology;Immunology;Impairment;in utero;Incidence;Infant;Infection;Inflammation;Inflammatory;Inflammatory Response;insight;Interleukin-1;interleukin-1 receptor-associated kinase;intraamniotic infection;Intubation;Knockout Mice;Knowledge;Life;Lung;lung development;Lung Diseases;lung health;lung injury;Measures;Mechanics;Mediating;Mediator;Mentors;Messenger RNA;Morbidity - disease rate;mortality;mouse model;Multicenter Neonatal Research Network;Mus;National Institute of Child Health and Human Development;Neonatal Mortality;Newborn Infant;offspring;Oscillometry;Outcome;Pathogenicity;Pathway interactions;Physiology;Placenta;Population;premature;Premature Birth;Premature Infant;prenatal exposure;preterm newborn;prevent;Prevention;Prevention therapy;Program Development;Prospective, cohort study;Public Health;pulmonary function;Pulmonary Hypertension;pup;Research Support;respiratory;Risk;Risk Factors;Signal Transduction;statistics;Techniques;Testing;Therapeutic;therapeutic target;Time;Trachea;Training;transcriptome;transcriptomics;Translational Research;Umbilical Cord Blood;United States National Institutes of Health;vascular injury;Work

PROJECT_TITLE: IL17 mediates chorioamnionitis induced lung damage

STUDY_SECTION: MCBS

STUDY_SECTION_NAME: NHLBI Mentored Clinical and Basic Science Study Section[MCBS (MA)]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Complementary and Integrative Health;Diabetes;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Nutrition;Prevention;Racial and Ethnic Minority Health Research;Women's Health Research

ORG_CITY: WASHINGTON

ORG_DEPT: MISCELLANEOUS

ORG_NAME: GEORGE WASHINGTON UNIVERSITY

ORG_STATE: DC

PHR: Narrative  This proposed diversity supplement will extend the parent grant's research on magnesium (Mg) supplementation in patients with diabetes mellitus (DM) and heart failure (HF), examining its differential impact across diverse racial, ethnic, and gender groups. In this research, we will examine the differential effect of Mg supplementation and replacements on incident HF in patients with DM and on mortality and hospitalization in patients with HF by race, gender, and ethnicity. We will also study providers’ and patients’ perspectives on Mg supplementation.

PI_NAMEs: AHMED, ALI ;WU, WEN-CHIH ;ZENG, QING  (contact)

PROGRAM_OFFICER_NAME: ANAYA, GABRIEL

PROJECT_TERMS: Address;Affect;African American;African American population;African Women;Age;aged;American;Biochemical Reaction;Biological;biological sex;black men;black patient;black women;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;caucasian American;Centers for Disease Control and Prevention (U.S.);Cessation of life;Clinical;clinical practice;Congestive Heart Failure;Consumption;coronary fibrosis;Data;Death Rate;Diabetes Mellitus;Diagnosis;Diet Habits;Dietary Magnesium;dietary supplements;Disease;Disparity;disparity reduction;Equilibrium;ethnic difference;Ethnic Origin;Ethnic Population;Female;Focus Groups;follow-up;Functional disorder;Funding;Gender;gender difference;Glucose;health equity promotion;Heart failure;high risk;Hispanic;Hispanic Populations;Hospitalization;Hospitals;Human body;Hypomagnesemia;improved;Incidence;Inflammation;insight;insulin secretion;insulin signaling;Intake;Intervention;Investigation;Jackson Heart Study;Knowledge;Light;Literature;Magnesium;Magnesium Deficiency;male;men;Methods;Mg supplementation;Minority Groups;mortality;mortality risk;Not Hispanic or Latino;Oral;Outcome;Oxidative Stress;Paper;parent grant;Pathway interactions;Patient Recruitments;Patient Self-Report;Patients;Peripheral;Physicians;Pilot Projects;Plasma;Play;Population;population health;Population Heterogeneity;Populations at Risk;post-market;Prevention;Provider;Race;racial difference;racial diversity;racial population;readmission rates;Reporting;Research;Research Project Grants;Risk;Risk Factors;Role;Safety;Sampling;Serum;Serum Magnesium Level;sex;Signal Transduction;Structure of beta Cell of islet;Subgroup;Testing;translational study;United States Department of Veterans Affairs;Veterans;Woman;women patients;Women's Health;Women's mortality

PROJECT_TITLE: Diversity Supplement

STUDY_SECTION: CHSA

STUDY_SECTION_NAME: Cancer, Heart, and Sleep Epidemiology A Study Section[CHSA]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biotechnology;Brain Disorders;Dementia;Genetics;Human Genome;Mental Health;Neurodegenerative;Neurosciences;Schizophrenia;Serious Mental Illness;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_DEPT: PHARMACOLOGY

PHR: PROJECT NARRATIVE Several lines of evidence indicate that SNX19 may influence neurodegeneration. The goal of this project is to study SNX19 at single-cell resolution in aging autopsy brains, and study the impact of SNX19 on neuronal functions, including synapse loss, autophagy, and neuronal hypoactivity, using 3D cerebral organoids. This project will greatly advance our understanding of SNX19 in neurodegeneration and may reveal potential targets to prevent or treat neurodegenerative diseases.

PI_NAMEs: MA, LIANG  (contact)

PROGRAM_OFFICER_NAME: HAAKENSON, CHELSEA MARIE

PROJECT_TERMS: 3-Dimensional;abeta accumulation;Activities of Daily Living;Affect;Aging;aging brain;Alleles;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Animals;apolipoprotein E-4;Astrocytes;Autophagocytosis;Autopsy;Biochemistry;Biology;Brain;brain cell;brain tissue;Calcium;Cell Line;cell type;Cells;Cerebrospinal Fluid;Cerebrum;Characteristics;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;Cognitive deficits;comorbidity;CRISPR/Cas technology;Data;Dementia;density;Development;Digit structure;Disease;DNA Methylation;drug development;efficacious treatment;ErbB4 gene;excitatory neuron;Experimental Designs;Experimental Models;experimental study;Functional disorder;Gender;Gene Expression;Gene Modified;General Population;Genes;Genetic;genetic association;Glutamates;Goals;Grant;Homeostasis;Human;Human Engineering;human induced pluripotent stem cells;human RNA sequencing;Hyperactivity;Image;Impaired cognition;In Situ Hybridization;in vitro Model;Individual;induced pluripotent stem cell;Induced pluripotent stem cell derived human neuron;inhibitory neuron;insight;Intervention;Investigation;Knock-out;Link;live cell imaging;Maintenance;Microglia;Modeling;Molecular;molecular phenotype;Nerve Degeneration;Neurites;Neurobiology;Neurodegenerative Disorders;Neurofibrillary Tangles;Neuroglia;Neuronal Dysfunction;Neurons;neuropathology;neuropsychiatric disorder;neurotransmission;new therapeutic target;novel;NRG1 gene;oligodendrocyte progenitor;Oligodendroglia;Organoids;overexpression;Pathogenesis;Pathology;Pathway interactions;Persons;Phenotype;postsynaptic neurons;Potassium Chloride;prevent;Process;protein aggregation;Proteins;Relative Risks;Research;Resolution;response;Role;Schizophrenia;schizophrenia risk;Senile Plaques;Signal Transduction;single molecule;single nucleus RNA-sequencing;stem cell model;stem cells;Symptoms;Synapses;Synaptic plasticity;System;tau aggregation;Techniques;Testing;transcriptomics;Treatment Protocols;Vesicle;Work

PROJECT_TITLE: The role of SNX19 in aging brains at single cell resolution and cerebral organoids

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development For Early Career Investigators Study Section [AGCD-2]


NIH_SPENDING_CATS: Autoimmune Disease;Brain Disorders;Genetics;Human Genome;Multiple Sclerosis;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: Oligodendrocyte precursor cells (OPCs) are the most abundantly mitotic cell in the brain and give rise to oligodendrocytes responsible for myelination through the process of OPC differentiation, which is critical to neurodevelopment and maintenance of myelination, yet the processes mediating this constancy are unclear. Oligodendroglia dynamics require the precise timing of transcription factors expression, that is essential for efficiently remyelinating lesions. The proposed research will determine genetic mechanisms through which the main circadian factor BMAL1 and other key transcription factors control OPC differentiation during myelination, providing critical insights into both normal and aberrant myelination associated with the demyelinating neurological disorder multiple sclerosis.

PI_NAMEs: ROJO CAPITANIO, DANIELA  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Affect;Alzheimer's disease risk;ARNTL gene;Automobile Driving;Award;Binding;Brain;career;Cell Cycle Regulation;Cell Differentiation process;Cell division;Cell Proliferation;Cells;Characteristics;Chromatin;circadian;Circadian Dysregulation;Circadian Rhythms;Communication;comparative;CRISPR screen;Data;data integration;Demyelinations;design;Disease;Elements;Enhancers;Environment;experimental study;Feedback;Fostering;Gene Expression;Genes;Genetic;Genetic Transcription;Genome;genomic variation;Genomics;Goals;Hour;Human;Human Genome;Impairment;Individual;induced pluripotent stem cell;insight;Interleukin-1 beta;Knock-out;Knowledge;Lesion;Link;Maintenance;MAP Kinase Gene;Mediating;Mentors;migration;Mitotic;Modeling;mouse model;Multiple Sclerosis;Mus;Mutation;Myelin;myelination;Nature;neonatal mice;Nerve;Nervous System Disorder;neurodevelopment;Neuroglia;Neurons;novel;novel therapeutics;Nucleic Acid Regulatory Sequences;oligodendrocyte progenitor;Oligodendroglia;p38 Mitogen Activated Protein Kinase;Pathway interactions;Periodicity;Persons;Phase;precursor cell;Process;Proliferating;Protocols documentation;Recovery;Regulation;Regulatory Element;remyelination;Research;Risk;Role;Signal Pathway;single cell ATAC-seq;single-cell RNA sequencing;Sleep;Slice;SMARCA4 gene;Structure;Symptoms;System;targeted treatment;Techniques;Testing;Therapeutic;Time;Training;transcription factor;Transcriptional Regulation;transcriptome;transcriptome sequencing;Transmission Electron Microscopy;Untranslated RNA;Variant

PROJECT_TITLE: Transcriptional regulation of oligodendroglial differentiation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Mental Health;Mental Illness;Neurosciences

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: Project Narrative This project proposal uses computational modeling, psychopharmacology, and pharmaco-fMRI to investigate the neural and computational mechanisms by which people allocate mental effort when faced with sustained and uncontrollable stress. These data will provide the first direct and multi-modal examination of how people process the controllability of sustained stressors to guide dissociable strategies for allocating mental effort. Collectively, this research will provide an important foundation for understanding the computations, networks, and neurotransmitter systems that drive effortful thoughts and actions, and when and why they fail to do so (e.g., motivational impairments in depression, anxiety, OCD, Alzheimer’s).

PI_NAMEs: YEE, DEBBIE  (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Acute;acute stress;Affect;Alzheimer's Disease;Anxiety;Attention;Behavior Control;behavior prediction;Behavioral inhibition;behavioral study;Brain;Clinical;Cognition;Cognitive;cognitive control;college;Complex;Computer Models;Data;Diagnostic;Disease;Dorsal;dorsal raphe nucleus;Dose;Double-Blind Method;Educational workshop;Emotional;Environment;Escitalopram;experience;Exposure to;Faculty;Foundations;Freezing;Functional Magnetic Resonance Imaging;Goals;Health;healthy volunteer;Human;Human Volunteers;Impairment;improved;Individual;insight;Link;Maintenance;Maps;Medial;Mental Depression;Mental disorders;Modeling;Motivation;multimodality;National Institute of Mental Health;negative affect;neural;neural circuit;neural network;Neural Pathways;neuromechanism;Neuromodulator;Neurotransmitters;novel;Occupations;Participant;Patients;Personal Satisfaction;Persons;pharmacologic;Pharmacology;Placebos;Play;Positioning Attribute;Prefrontal Cortex;Process;Productivity;Psyche structure;psychiatric symptom;Psychopharmacology;Punishment;Research;Research Personnel;resilience;response;Rewards;Role;Selective Serotonin Reuptake Inhibitor;Serotonin;Shock;societal costs;Specificity;Strategic Planning;Stress;stressor;System;Task Performances;Testing;Thinking;Time;Training;Vulnerable Populations;Work

PROJECT_TITLE: Neurocomputational mechanisms of serotonin, sustained stress, and mental effort allocation

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-M (03)]


ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Estrogen;Neurodegenerative;Neurosciences;Prevention;Women's Health Research

ORG_CITY: FORT WORTH

ORG_NAME: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR

PHR: Public Health Narrative Women have a two-fold increased lifetime risk for Alzheimer’s disease (AD) compared to men, an effect that cannot be fully remediated by estrogen supplementation, suggesting that the underlying mechanism is complex. Recent reports have suggested that angiotensin II (ANG II) is involved in AD pathogenesis and that post-menopausal women have higher ANG II activation than aged men. The goal of these studies is to elucidate sex differences in AD pathogenesis by examining the interplay between sex hormones, sex chromosome complement, and ANG II signaling, which may explain the increased incidence of AD in women.

PI_NAMEs: CUNNINGHAM, REBECCA L (contact)

PROJECT_TERMS: Acceleration;Affect;aged;aging brain;aging population;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease related dementia;Alzheimer's disease risk;American;Amyloid beta-Protein;Androgens;Angiotensin II;Angiotensins;Aromatase;Automobile Driving;Autopsy;Brain;brain tissue;Characteristics;Complement;Complex;Data;Dementia;Development;Disease Progression;Disproportionately impacts women;Drug Prescriptions;Estradiol;Estrogens;Exhibits;Exposure to;Female;Four Core Genotypes;Genotype;Goals;Gonadal Hormones;Gonadal Steroid Hormones;High Risk Woman;Hippocampus;Hormonal;hormone deficiency;Hormone replacement therapy;Hormones;hyperphosphorylated tau;Impaired cognition;Incidence;inhibitor;Intervention Studies;Lead;Letrozole;lifetime risk;Link;male;Mediating;Mediator;men;Menopause;Modeling;Neurobiology;Neurons;Outcome;Ovarian;Ovary;Oxidative Stress;Pathogenesis;Pathologic;peptide hormone;Peptidyl-Dipeptidase A;Pharmaceutical Preparations;Ploidies;Postmenopause;prevent;Public Health;Rat Transgene;Rattus;receptor;receptor expression;Receptor Inhibition;remediation;Reporting;reproductive;response;Risk;Risk Factors;Rodent;Role;senescence;Senile Plaques;sex;Sex Bias;Sex Chromosomes;Sex Differences;Signal Transduction;Stanolone;stressor;Supplementation;tau aggregation;Testing;Testis;United States;vasoconstriction;Vasoconstrictor Agents;Woman;women's treatment;Work

PROJECT_TITLE: The Impact of Sex and Hippocampal Angiotensin II on Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 AN-Q (55)]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Neurosciences;Pediatric

PHR: Project Narrative The goal of the proposed research is to pinpoint the factors that contribute to the development of linguistic proficiency in young children, with a focus on an implicit form of learning that assesses phonology-to-orthography mapping, a hallmark of reading skill and an assay of reading interventions. There are widespread individual differences in language skills across the US population: as many as 30 million Americans only have rudimentary literacy skills, which negatively affects their health, social, and general life outcomes. Understanding the basic mechanisms that contribute to spoken and written language development will help better inform educational and remediation practices in both typical and atypical populations, and the tasks developed in this proposal may also be applied as diagnostic tools to identify children who may be at risk for reading-related difficulties.

PI_NAMEs: ISBILEN, ERIN  (contact)

PROGRAM_OFFICER_NAME: MILLER, BRETT

PROJECT_TITLE: Behavioral and neural measures of phonological-to-orthographic transfer in young children

STUDY_SECTION_NAME: Biobehavioral and Behavioral Sciences Study Section[CHHD-H]


NIH_SPENDING_CATS: Aging;Genetics;Nutrition

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

PHR: Narrative Aging is a major risk factor for the onset of chronic diseases and thus slowing aging holds the potential to improve human health. In this project, we utilize a host-microbe model to investigate how microbial stress responses regulate host stress signaling and aging. This study aims to discover novel targets for manipulating the microbes to modulate stress tolerance and slow aging.

PI_NAMEs: BHAT, AJAY  (contact)

PROGRAM_OFFICER_NAME: CARTER, CHRISTY

PROJECT_TERMS: Address;Affect;Age;age-related disease;Aging;aging related;aging related disease;Bacteria;bacterial resistance;biological adaptation to stress;Caenorhabditis elegans;career;Cells;Chronic Disease;Coculture Techniques;Colon;Consumption;Data;Data Collection;Development;Diet;dietary;Dietary Component;DNA sequencing;Engineered Probiotics;Environment;environmental stressor;Equilibrium;Escherichia coli;Evolution;Exhibits;experience;experimental study;Exposure to;Formulation;Gene Cluster;Gene Modified;Gene Mutation;Generations;Genes;Genetic;Genetic Variation;Glucose;Goals;Health;healthy aging;Homeostasis;host-microbe interactions;Human;Immune;Immune system;improved;Innate Immune Response;Intestinal permeability;Intestines;Investigation;Iron;K-Series Research Career Programs;Knock-out;Laboratories;life span;Longevity;Maintenance;MAP Kinase Gene;Medical;Mentorship;Metabolic;Metabolic Pathway;Metabolism;metabolomics;Michigan;Microbe;microbial;Microbial Genetics;microorganism;Mitochondria;Modeling;Mus;Mutation;novel;novel therapeutics;nutrition;Nutritional;Organism;Oxidation-Reduction;Oxidative Stress;p38 MAPK Signaling Pathway;p38 Mitogen Activated Protein Kinase;Paraquat;Pathway interactions;Phase;Physiology;Play;Process;Proteins;Regulation;Regulator Genes;Research;Resistance;response;Risk Factors;Role;screening;Signal Pathway;Signal Transduction;Specificity;Stress;stress tolerance;stressor;Sulfur;System;Techniques;Temperature;Testing;Time;timeline;Training;Universities;whole genome;Xenobiotics

PROJECT_TITLE: Mechanistic understanding of host-microbe interactions in regulating stress response and lifespan

STUDY_SECTION_NAME: Career Development Facilitating The Transition to Independence Study Section[AGCD-1]


NIH_SPENDING_CATS: Atherosclerosis;Bioengineering;Biomedical Imaging;Cardiovascular;Heart Disease;Heart Disease - Coronary Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

ORG_CITY: CLEVELAND

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: CASE WESTERN RESERVE UNIVERSITY

PHR: Narrative We will develop methods for the non-invasive, quantitative evaluation of coronary artery disease in computed tomography angiography images. With success, our research will lead to improved detection of coronary artery disease and evaluation of its severity, paving the way for personalized treatments.

PI_NAMEs: LEE, JUHWAN  (contact)

PROGRAM_OFFICER_NAME: SMITH, SHARON M

PROJECT_TERMS: 3-Dimensional;Adverse event;adverse outcome;Algorithms;Angiography;Arterial Fatty Streak;Arteries;Atherosclerosis;automated assessment;Benchmarking;Bioinformatics;Biological Markers;Biometry;Blood Platelets;calcification;Cardiology;cardioprotection;Cardiovascular Diseases;Cardiovascular system;career;Catheters;Cause of Death;Characteristics;Cholesterol;Classification;Clinical assessments;comorbidity;Computer software;Coronary;Coronary Arteriosclerosis;Coronary artery;coronary computed tomography angiography;coronary event;Data;data mining;deep learning;Detection;Development;Diabetes Mellitus;Disease;Evaluation;Event;Exhibits;experience;explainable artificial intelligence;Fatty acid glycerol esters;Foundations;Future;Genes;Genomics;Goals;graph neural network;Heart;high risk;Image;Image Analysis;imaging modality;improved;Inflammation;Inflammatory;innovation;Intervention;Learning;Lesion;Licensing;Life Style;Lipids;Location;Logistic Regressions;Machine Learning;Macrophage;Medical;Mentored Research Scientist Development Award;metabolomics;Methods;Microscopic;Modeling;Morphology;multimodality;non-invasive imaging;novel;Oncology;Optical Coherence Tomography;Patients;personalized medicine;pharmacologic;Physicians;precision medicine;Predictive Value of Tests;prevent;Process;Psoriasis;Quantitative Evaluations;Recording of previous events;Reporting;Research;Research Personnel;research study;Resolution;revascularization;Risk;risk prediction;Severities;Specificity;Stenosis;success;Taiwan;Techniques;Technology Transfer;Texture;Therapeutic;Thick;Thinness;Time;Training;Translations;treatment strategy;virtual;Work;X-Ray Computed Tomography

PROJECT_TITLE: Multi-modality evaluation of high-risk coronary atherosclerotic plaque


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Rare Diseases;Social Determinants of Health;Vector-Borne Diseases

PHR: Project Narrative Malaria kills over 600,000 people every year, and causes hundreds of millions of additional infections that impose significant financial burdens on the individuals infected, their families, their communities, and the health system. The Amazon region aims to eliminate the disease by 2030, but there are important gaps in our understanding of malaria epidemiology that will prevent successful elimination. The objective of this proposal is to address one of those gaps: how human mobility contributes to malaria population structure, importation, and diffusion, and do so by leveraging data fusion to effectively link efficient, cost-effective survey and genotyping methods.

PI_NAMEs: JANKO, MARK MCDERMOTT (contact)

PROGRAM_OFFICER_NAME: RAO, MALLA R

PROJECT_TERMS: Address;analytic epidemiology;Applied Skills;Bayesian learning;Cellular Phone;Cities;Climate;climate-related health;Collaborations;Communicable Diseases;Communities;Community Networks;Complex;cost;cost effective;Data;Data Collection;data fusion;Data Set;Data Sources;Decision Making;design;Development;Diffusion;Disease;disorder control;Distant;Effectiveness;Environmental Risk Factor;Epidemiology;Failure;Family;Financial Hardship;Funding;Genes;Genetic;Genome;genomic data;genomic epidemiology;Genomics;Genotype;Geography;Goals;Grant;Health system;Human;Incidence;Individual;Infection;Informatics;Intervention;Link;machine learning model;Malaria;malaria transmission;Measures;Methods;Migrant;migration;Modeling;Molecular;network models;Network-based;novel;Parasites;participatory mapping;Pattern;Persons;Peru;Peruvian;Plasmodium falciparum;Plasmodium vivax;Population;population health;prevent;programs;Research Design;Risk;Role;Rural;Sampling;Seasons;skill acquisition;skills;social;Social Network;Source;Stochastic Processes;Structure;Surveys;Testing;tool;Training;training opportunity;transmission process;Travel;Work

PROJECT_TITLE: Effectively Linking Molecular Informatics and Network Analytics to Reduce Malaria (ELIMINAR-Malaria)

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness

PHR: PROJECT NARRATIVE Statistical fine-mapping identifies a handful of putative causal variants from hundreds of GWAS loci for psychiatric disorders, but due to the unavailability of methods, current findings are primarily based on analysis of the European cohort, leading to bias in causal genetic variant discovery and limiting the resolution of findings. This application proposes to develop novel statistical fine-mapping methods for admixed populations and the gene-based Neanderthal introgression burden and performs the most inclusive fine-mapping analysis on psychiatric disorders. By integrating genomic data across ancestries, this work will create a comprehensive list of fine-mapped variants/genes for psychiatric disorders, which serves as a valuable resource for experimentalists and clinicians, providing a generalized list of candidates for translating genetic findings into innovative preventative and therapeutic strategies.

PI_NAMEs: YUAN, KAI  (contact)

PROJECT_TERMS: Address;Admixture;Affect;African American population;Algorithms;Award;Awareness;causal variant;Chromosome Mapping;Chromosomes;cohort;Complex;Data;Data Analyses;Data Set;design;Development;diverse data;Educational process of instructing;Educational workshop;Ensure;Environment;European;European ancestry;exome sequencing;experience;General Hospitals;Genes;Genetic;Genetic Models;Genetic Structures;genetic variant;Genetic Variation;Genome;genome sequencing;genome wide association study;genomic data;genomic locus;Genomic Segment;Goals;Heterogeneity;Human;Human Genetics;Human Genome;improved;Individual;innovation;International;Jordan;Leadership;Linkage Disequilibrium;Maps;Massachusetts;Memory;Mental disorders;Mentors;Mentorship;method development;Methodology;Methods;Modeling;Modernization;neglect;Nervous System;Neurologic;novel;open source;Persons;Phase;Phenotype;Population;psychogenetics;Research;Research Personnel;Research Training;Resolution;Resources;Sample Size;Scientist;skills;Software Engineering;Statistical Methods;Structure;success;symposium;Testing;Therapeutic;Training;Translating;translational genetics;Underrepresented Populations;United States;Variant;Work

PROJECT_TITLE: Whole chromosome fine-mapping integrating diverse ancestries for psychiatric disorders


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Nanotechnology;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Traumatic Head and Spine Injury

ORG_CITY: TROY

ORG_NAME: RENSSELAER POLYTECHNIC INSTITUTE

ORG_STATE: NY

PHR: Project Narrative Traumatic spinal cord injury (SCI) is a devastating condition that affects thousands of Americans every year and there are currently no available treatments that restore lost function. There is an urgent need for biomaterial interventions that deliver drugs locally, as systemic administration results in limited drug titer at the injury site; however, current biomaterial approaches are not capable of responding to a patient’s unique inflammatory response. This proposal details the development of a prototype magnetic biomaterial composite capable of releasing precise dosages via magnetically triggered release of an anti-inflammatory growth factor to mitigate the reactivity of astrocytes and create a growth-permissive environment for axonal regeneration.

PI_NAMEs: GILBERT, RYAN J. (contact)

PROGRAM_OFFICER_NAME: KUMSA, DOE WONDWOSSEN

PROJECT_TERMS: Acute;Affect;American;Anti-Inflammatory Agents;Area;Astrocytes;Axon;axon regeneration;Biocompatible Materials;Biological Assay;Bone Marrow;calcein AM;Central Nervous System;Cicatrix;Collaborations;Conditioned Culture Media;Culture Media;cytokine;demographics;density;Development;Diameter;dosage;Drug Delivery Systems;drug release kinetics;Electrospinning;Environment;Enzyme-Linked Immunosorbent Assay;Fiber;Fibroblasts;Frequencies;functional restoration;Future;Gene Expression;Growth;Growth Factor;improved;Individual;Inflammation;Inflammatory;Inflammatory Response;injured;Injury;innovation;Intervention;iron oxide nanoparticle;Kinetics;Laboratories;Macrophage;magnetic field;Magnetism;Morphology;Natural regeneration;Neurites;Neuroglia;neuron loss;Neurons;neuroprotection;neurotoxic;patient variability;Patients;permissiveness;Pharmaceutical Preparations;Phenotype;Play;polycaprolactone;Polyethylene Glycols;Polymers;Proliferating;Property;Proteins;prototype;Regimen;release factor;repaired;Research;Role;scaffold;Scanning Electron Microscopy;Secondary to;Severities;Site;small molecule;spinal cord compression;Spinal cord injury;Stains;superparamagnetism;System;Techniques;Therapeutic;Therapeutic Intervention;Tissues;transcriptome sequencing;transforming growth factor beta3;Transmission Electron Microscopy;Traumatic injury

PROJECT_TITLE: Magnetically Triggered Protein Release for Varying Severities of Spinal Cord Injury

STUDY_SECTION: DBTD

STUDY_SECTION_NAME: Drug and Biologic Therapeutic Delivery Study Section[DBTD]


NIH_SPENDING_CATS: Climate-Related Exposures and Conditions;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Kidney Disease;Prevention

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

PHR: PROJECT NARRATIVE Climate change has widespread and consequential impacts on human health, one of which may be the development of a form of kidney disease in Central America related to heat stress exposure called Mesoamerican Nephropathy. This project studies mechanisms connecting heat stress and Mesoamerican Nephropathy, with a particular focus on metabolic derangements arising during kidney injury that may be targeted with an oral B-vitamin to protect against disease. Understanding how heat stress produces kidney injury and identifying ways to help mitigate this injury is of vital importance in Mesoamerican Nephropathy and beyond as extreme heat events become more and more frequent globally with climate change.

PI_NAMEs: RAINES, NATHAN  (contact)

PROGRAM_OFFICER_NAME: GREER, RAQUEL CHARLES

PROJECT_TERMS: Acute;Acute Renal Failure with Renal Papillary Necrosis;Agricultural Workers;Agriculture;Anabolism;Area;Automobile Driving;Biological Markers;Biopsy;career;career development;Central America;Chronic;Chronic Kidney Failure;climate change;climate-related health;Clinical;Clinical Trials;Data;design;Development;Development Plans;Diagnostic;Disease;Dose;double-blind placebo controlled trial;Environmental Exposure;Epidemiology;Event;Exercise;Exertion;experience;Exposure to;extreme heat;Functional disorder;Goals;Health;heat injury;Heat Stress;high risk;Human;Humidity;Impairment;improved outcome;indexing;Individual;Inflammation;Inflammatory;Injury;Injury to Kidney;interest;intervention program;Ischemia;Israel;Kidney;Kidney Diseases;LCN2 gene;Leadership;Link;Measurement;Measures;medical schools;men;Mesoamerican;Metabolic;Metabolism;metabolomics;Modeling;new therapeutic target;Niacinamide;Nicotinamide adenine dinucleotide;novel;Occupational;Oral;Oral Administration;Outcome;Participant;Physiological;Physiology;placebo controlled trial;placebo group;Placebos;Population;Populations at Risk;prevent;programs;Protocols documentation;quinolinate;Randomized;Recurrence;Renal function;Research;Research Personnel;Research Priority;Resources;response;Risk;Risk Factors;Role;Rural Community;Saccharum;Sampling;shift work;skills;System;Temperature;Testing;Therapeutic;therapeutic target;Training;treatment response;Tryptophan;United States National Institutes of Health;urinary;Urine;Vitamin B Complex;Vulnerable Populations;Work

PROJECT_TITLE: Nicotinamide Adenine Dinucleotide (NAD+) Metabolism During Observational and Experimental Heat Stress and the Effect of Niacinamide Among Individuals at Risk for Mesoamerican Nephropathy

STUDY_SECTION_NAME: Kidney, Urologic and Hematologic Diseases D Study Section[DDK-D]


NIH_SPENDING_CATS: Aging;Biotechnology;Cancer;Cancer Genomics;Genetics;Human Genome;Prostate Cancer;Urologic Diseases

ORG_CITY: NEW YORK

ORG_DEPT: UROLOGY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

PHR: Project Narrative We propose to inhibit Wnt/-catenin signaling in prostate cancer using a synthetic macrocycle designed to interfere with -catenin interaction with its TCF binding partner.

PI_NAMEs: LOGAN, SUSAN K. (contact)

PROGRAM_OFFICER_NAME: KONDAPAKA, SUDHIR B

PROJECT_TERMS: abiraterone;Acetylation;Affect;Androgen Antagonists;androgen independent prostate cancer;Androgen Receptor;Androgens;beta catenin;Binding;Cancer Cell Growth;Cancer Etiology;Cell Line;Cell model;Cell Nucleus;Cells;Cessation of life;ChIP-seq;combat;Data;deprivation;design;Disease;Disease Progression;DNA-Binding Proteins;Embryo;enzalutamide;experimental study;Family;Generations;Genes;Genetic;Genetic Transcription;Genetically Engineered Mouse;genome-wide;Genomics;Goals;Growth;Hormonal;Hybrids;Immune;Implant;in vivo Model;Individual;inhibitor;knock-down;Lead;lead candidate;Life Expectancy;Localized Disease;Malignant neoplasm of prostate;Malignant Neoplasms;Mediating;men;Modeling;Mus;Mutate;Mutation;N-terminal;novel;novel therapeutic intervention;Oncogenic;Organoids;Pathway interactions;Patients;Peptides;Peptoids;Prognosis;Proliferating;Prostate;prostate cancer cell;prostate cancer model;Prostatic Neoplasms;Protein Engineering;PTEN gene;Resistance;Resistance development;response;Role;Shapes;Signal Pathway;Signal Transduction;Specificity;Structure;Survival Rate;T cell activating factor;TCF Transcription Factor;TCF7L2 gene;therapeutic target;therapy resistant;three dimensional cell culture;TP53 gene;transcription factor;transcriptome;transcriptome sequencing;tumor;tumor-immune system interactions;Up-Regulation;uptake;WNT Signaling Pathway;Xenograft procedure;Zebrafish

PROJECT_TITLE: Macrocycle inhibition of beta-catenin mediated transcription in prostate cancer

STUDY_SECTION: MCTA

STUDY_SECTION_NAME: Mechanisms of Cancer Therapeutics A Study Section[MCTA]


ORG_CITY: Newark

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

ORG_STATE: NJ

PHR: PROJECT NARRATIVE The aims of this proposal are to identify prevalent patterns of beliefs (belief classes) that underlie the perception that e-cigarettes are as or more harmful than cigarettes among adults who smoke, use these belief classes to develop, pilot test, and refine messages employing neurocognitive and interview responses, and test messages for effects on change in e-cigarette beliefs, intentions, and behaviors among adults who smoke. Educational messages for adults who smoke about the relative risks of e-cigarettes versus cigarettes have the potential to improve understanding of harm reduction and potentially increase e-cigarette use, which may reduce exposure to harmful chemicals and the overall harm from tobacco use. Findings from the proposed research can inform future use of belief class messaging as a communication strategy in educational messaging, and the use of neuroimaging to more accurately predict message effectiveness during pretesting.

PI_NAMEs: WEIGER, CAITLIN VICTORIA (contact)

PROGRAM_OFFICER_NAME: LIN, YU

PROJECT_TERMS: Acute;Address;Adult;Area;Behavior;behavior change;behavior prediction;behavioral outcome;Belief;Brain;career;Chemicals;Cigarette;cigarette smoke;Cigarette Smoker;Cognitive;combustible cigarette;Communication;Communication Research;Complex;Dangerousness;Data;design;Development;Education;Effectiveness;effectiveness evaluation;effectiveness measure;Electronic cigarette;electronic cigarette use;Ensure;evidence base;experience;Experimental Designs;Exposure to;functional near infrared spectroscopy;Future;Harm Reduction;Health;health communication;health goals;improved;Intention;interest;Interview;lung injury;Measures;Methodology;Methods;Neurocognitive;neuroimaging;Neurosciences;Nicotine;nicotine use;novel;Pathway interactions;Patient Self-Report;Pattern;Perception;Persons;Phase;pilot test;Population;prevent;Public Health;Qualitative Methods;Relative Risks;Research;Research Priority;response;Risk;skills;Smoke;Smoker;Smoking;Subconscious;Surveys;tailored messaging;Techniques;Testing;Tobacco;tobacco products;tobacco regulatory science;Tobacco use;tool;toxicant;Training;Traumeel S;Variant

PROJECT_TITLE: Misperceptions that prevent complete switching to e-cigarettes among adult smokers: A more nuanced communication strategy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 RCCS-Q (50)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Clinical Research;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Patient Safety;Prevention

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: Project Narrative Clostridioides difficile is the most common healthcare-associated infection, characterized by severe diarrhea and inflammation of the colon, with an estimated 500,000 cases per year in the U.S. and an annual economic burden of >$5 billion. We have an incomplete understanding of how antibiotic usage, forms of innate and acquired antimicrobial resistance among C. difficile strains, and patient co-variates, including immune status and other co-morbid conditions impact risks for disease development. My proposed research objectives will 1) support genomic-epidemiologic analyses of high-dimensional datasets with patient and epidemiologic data to improve our understanding of pathogen and patient factors that promote C. difficile colonization and infection and 2) optimize an active C. difficile hospital surveillance program through the development of more accessible clinical detection assays and functional antibiograms to better detect CD carriage as well as identify factors that may increase patient risks for carriage.

PI_NAMEs: CERSOSIMO, LAURA MARIE (contact)

PROGRAM_OFFICER_NAME: RANALLO, RYAN

PROJECT_TERMS: Ablation;Active Learning;Anaerobic Bacteria;Animals;Antibiotic Resistance;Antibiotics;Antimicrobial Resistance;Appointment;Bioinformatics;bioinformatics tool;Biometry;career;career development;Clinical;clinical diagnostics;Clinical Microbiology;Clostridium difficile;Colitis;Collaborations;Colonic inflammation;Communicable Diseases;community center;Community Hospitals;comorbidity;complex data;computing resources;Data;Data Analyses;Data Set;Detection;detection assay;Development;Diagnosis;Diagnostic;diagnostic assay;diagnostic strategy;Diarrhea;disorder control;disorder risk;Economic Burden;education resources;Educational workshop;Electronic Health Record;enhancing factor;enteric pathogen;Environment;epidemiologic data;Epidemiologist;Epidemiology;experience;food science;Generations;Genes;genomic data;genomic epidemiology;Genomics;Goals;Growth;gut colonization;gut health;hands-on learning;Health;Health Care Costs;health care settings;Healthcare;healthcare-associated infections;high dimensionality;Hospitals;Immunocompromised Host;immunological status;Immunosuppression;improved;Individual;Infection;Infection Control;infection risk;Infectious Disease Epidemiology;Inpatients;Institution;Intensive Care Units;International;Intervention;Laboratories;Leadership;Link;Measures;medical schools;Mentors;Methods;Microbiology;microbiota;Molecular;Molecular Epidemiology;Morbidity - disease rate;mortality;multidimensional data;Nosocomial Infections;Oncology;opportunistic pathogen;pathogen;Pathogen detection;Patient Isolation;patient population;Patient risk;Patients;Pattern;Pharmacy facility;Phenotype;Population;population based;prevent;Prevention program;Prevention strategy;Public Health;Recommendation;Reproduction spores;Research;research and development;Research Personnel;Research Training;Resistance profile;Resolution;Risk;Risk Factors;Rotation;skills;Statistical Data Interpretation;statistical learning;Surveillance Program;Testing;tool;Toxin;Training;transmission process;trend;ward;Woman

PROJECT_TITLE: Molecular Epidemiology and Surveillance Optimization of Clostridioides difficile in Asymptomatic Patients


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Palliative Care;Pediatric;Social Determinants of Health

ORG_CITY: PHILADELPHIA

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Family caregivers of the estimated 698,000 children in the U.S. who are living with serious illness are challenged by gaps in the home-based healthcare system and by social determinants of health (SDOH) that, together, have deleterious impacts on children’s and families’ wellbeing, particularly for those living in historically marginalized communities. Home-based pediatric palliative care (PPC) teams are uniquely poised to support children and families living at home but lack information about families’ day-to-day care experiences and if care is aligned with families’ needs over time. Routinely collecting and rapidly feeding back digitally- captured data about families’ home-based PPC experiences to PPC teams may a) enable tailored clinical actions to increase concordance between families’ needs and home-based PPC, b) support teams to address the health system and SDOH challenges faced by children and families, and c) improve outcomes for children living with serious illness and their families.

PI_NAMEs: BOYDEN, JACKELYN Y (contact)

PROGRAM_OFFICER_NAME: BOWEN, MARY ELIZABETH

PROJECT_TERMS: acceptability and feasibility;Address;Award;Back;care coordination;care outcomes;care providers;care systems;career;Caring;Child;Child Care;Child Rearing;Child Support;Childhood;chronic care model;Clinical;clinical care;clinical decision support;Communication;Communities;community engaged intervention;community engaged research;Complex;Data;digital;Dimensions;Economics;Employment;Enrollment;Equity;experience;Family;Family Caregiver;Feedback;feeding;Foundations;Funding;Future;Goals;Health;health equity;Health system;Healthcare Systems;Home;Hospice Care;Hospitals;Household;improved outcome;Interdisciplinary Study;Intervention Studies;lens;marginalized community;Measures;Medical;Mentorship;Outcome;Outpatients;Palliative Care;Participant;Pediatric Hospitals;Pennsylvania;Personal Satisfaction;Philadelphia;programs;Provider;Psyche structure;psychosocial;Quality of Care;Reporting;Research;Research Methodology;response;Services;Site;social;social health determinants;Social support;Strategic Planning;Stress;Symptoms;System;team-based care;Time;Training;Universities;Work

PROJECT_TITLE: EXPERIENCE-Feedback Project

STUDY_SECTION: NRRC

STUDY_SECTION_NAME: National Institute of Nursing Research Initial Review Group[NRRC (89)]