ED_INST_TYPE: SCHOOLS OF PHARMACY

NIH_SPENDING_CATS: Emerging Infectious Diseases;Eye Disease and Disorders of Vision;Infectious Diseases;Orphan Drug;Rare Diseases

ORG_CITY: LA JOLLA

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

PHR: PROJECT NARRATIVE Development of efficient new antimicrobials to Acanthamoeba keratitis is a critical need to avert future blindness. By leveraging the expertise of parasitology and ophthalmology we will test both pitavastatin and isavuconazonium sulfate against cysts and trophozoites of multiple genotypes of Acanthamoeba, and determine the efficacy of pitavastatin and isavuconazonium in an animal model of Acanthamoeba infection, either alone or in combination with each other. Successful completion of the proposed research will lead to repurposing of pitavastatin and isavuconazonium for the treatment of Acanthamoeba keratitis.

PI_NAMEs: DEBNATH, ANJAN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: 3-hydroxy-3-methylglutaryl-coenzyme A;Acanthameba infection;Acanthamoeba;Acanthamoeba Keratitis;Address;Age;Amebicides;Amoeba genus;Animal Model;antimicrobial;Biological Assay;Biology;Blindness;C57BL/6 Mouse;Catalytic Domain;Chlorhexidine;Chronic;Cicatrix;Clinical;Coenzyme A;Collaborations;Combined Modality Therapy;Contact Lenses;Cornea;corneal epithelium;cost;Cyst;cytotoxicity;Data;Development;Dose;drug discovery;Drug Industry;drug repurposing;druggable target;effective intervention;efficacy evaluation;efficacy study;Emerging Communicable Diseases;Enzymes;Ergosterol;Exhibits;experience;Eye Infections;FDA approved;Foundations;Future;Genes;Genome;Genotype;Goals;Growth;Hepatocyte;Human;in vivo;in vivo evaluation;Incidence;Individual;Infection;Inflammation;inhibitor;Intervention;isoprenoid;Keratitis;kidney cell;Mammalian Cell;melting;Membrane;mevalonate;Modeling;Morbidity - disease rate;mouse model;nanomolar;National Institute of Allergy and Infectious Disease;novel;Ophthalmology;Orphan Drugs;Outcome;Oxidoreductase;Pain;Parasites;Parasitic Eye Infections;Parasitology;Pharmaceutical Preparations;pharmacokinetics and pharmacodynamics;Phenotype;polyhexamethylene biguanide;Predisposition;Prodrugs;Production;Publishing;Rare Diseases;recurrent infection;Regimen;Research;Risk;small molecule inhibitor;Sterol Biosynthesis Pathway;Sterols;Sulfate;Testing;Time;Topical application;Toxic effect;Work

PROJECT_TITLE: Sterol Biosynthesis Inhibitors as Drug Leads for the Treatment of Acanthamoeba Eye Infection

STUDY_SECTION: DMPA

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology A Study Section [DMPA]


ADMINISTERING_IC: CA

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: LITTLE ROCK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROLOGY

ORG_FIPS: US

ORG_NAME: UNIV OF ARKANSAS FOR MED SCIS

ORG_STATE: AR

PHR: NARRATIVE Immune checkpoint inhibition therapy controls intracranial disease in 50% of melanoma patients with brain metastases indicating immunotherapy can be clinically effective in the brain. Our study will develop patient derived immunocompetent organoids that can be used to study immunomodulation of the melanoma brain metastases microenvironment leading to novel therapies. By developing these strategies, we have the potential to improve the lives of up to 40% of melanoma patients who develop brain metastases which is the leading cause of death in these patients and portends a median survival of less than a year.

PI_NAMEs: RODRIGUEZ, ANALIZ  (contact)

PROGRAM_OFFICER_NAME: DUGLAS TABOR, YVONNE

PROJECT_TERMS: Biological Assay;biomarker identification;Brain;Brain Neoplasms;Cancer Patient;Cause of Death;CD8-Positive T-Lymphocytes;Cell Communication;Cell Death;Cells;Characteristics;checkpoint inhibition;Clinical;Clinical Management;Clinical Trials;cost effective;cost efficient;CTLA4 gene;Data;Dependence;Development;Disease;Drug Screening;exhaustion;experience;Extracellular Matrix;Fibroblasts;Future;Goals;Immune;Immune Targeting;Immunocompetent;Immunologic Tests;Immunological Models;immunoregulation;Immunotherapy;improved;Incubated;innovation;Laboratories;Ligands;Malignant Neoplasms;Melanoma;Melanoma patient;Metastatic malignant neoplasm to brain;Methods;model development;Modeling;neoplastic cell;Nivolumab;novel therapeutics;Operative Surgical Procedures;Organoids;Parents;patient derived xenograft model;Patients;Phenotype;pre-clinical;Pre-Clinical Model;precision medicine;preservation;Proteomics;Radiation;receptor;Sampling;single-cell RNA sequencing;T-Cell Activation;T-Lymphocyte;T-Lymphocyte Subsets;Testing;Therapeutic;Therapeutic Studies;tumor;tumor-immune system interactions

PROJECT_TITLE: Development of immunocompetent melanoma brain metastases organoids

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 SRB-5 (J1)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Hypertension;Kidney Disease;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: BETH ISRAEL DEACONESS MEDICAL CENTER

ORG_STATE: MA

PHR: PROJECT NARRATIVE Preeclampsia, affecting 5-7% of pregnancies worldwide is one of the leading causes of maternal and perinatal morbidity and mortality. Our previous studies indicate that oxidative stress and decreased NO bioavailability are key features in this disease. We will study a dual function NO donor/redox modulator as a potential therapy in preeclampsia.

PI_NAMEs: ZSENGELLER, ZSUZSANNA KINGA (contact)

PROGRAM_OFFICER_NAME: MITCHELL, MEGAN S

PROJECT_TERMS: 3-nitrotyrosine;Address;Adenoviruses;Affect;Angiogenesis Inhibitors;Angiogenic Factor;Antioxidants;Biological;Biological Availability;Biological Markers;Blood Pressure;blood pressure medication;Blood Vessels;Brain Hypoxia-Ischemia;candidate selection;Canis familiaris;catalyst;Cells;Chemicals;Clinical;clinical candidate;Collaborations;Complication;design;Development;Disease;Dose;drug candidate;Drug Delivery Systems;Drug Kinetics;Early Intervention;Eclampsia;efficacy study;Environment;Esters;Etiology;Exhibits;Female;Foundations;Free Radicals;Functional disorder;functional group;Half-Life;high risk;Histologic;Human;Hydralazine;Hydrolysis;Hypertension;immunoreactivity;Impairment;improved;In Vitro;in vivo;in vivo Model;Incubated;inflammatory marker;innovation;Kidney;kidney dysfunction;lead optimization;Life;liquid chromatography mass spectrometry;Liver Microsomes;maternal hypertension;maternal morbidity;Measurement;Metabolic;Metabolism;Methods;Mitochondria;Modeling;mouse model;Mus;Nitrates;Nitric Oxide;Nitric Oxide Donors;Nitrogen;nitrosative stress;novel;oxidant stress;Oxidation-Reduction;Oxidative Stress;Oxygen;Parents;Pathogenesis;pathophysiology of preeclampsia;Pathway interactions;perinatal morbidity;Perinatal mortality demographics;Permeability;Peroxonitrite;pharmacokinetic characteristic;physical property;Placenta;Placentation;Plasma;Pre-Eclampsia;Pregnancy;Pregnancy Complications;Pregnancy Outcome;pregnant;premature;Premature Birth;Prevention;Prodrugs;Proteinuria;Proto-Oncogene Proteins c-akt;Publishing;Pyrrolidines;Rattus;Reaction;Reactive Nitrogen Species;Reactive Oxygen Species;Renal function;Renal Tissue;restoration;Rodent;Rodent Model;Series;Side;Solubility;Structure;Superoxides;Symptoms;Testing;Therapeutic;Time;Tissues;Up-Regulation;uptake;Vascular Endothelial Growth Factors;Vasodilator Agents;Water;water solubility;water testing

PROJECT_TITLE: Restoration of reduced nitric oxide bioavailability in Preeclampsia

STUDY_SECTION: DMPB

STUDY_SECTION_NAME: Drug Discovery and Molecular Pharmacology B Study Section[DMPB]


NIH_SPENDING_CATS: Biotechnology;Cancer;Cancer Genomics;Foodborne Illness;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Prevention;Urologic Diseases

ORG_CITY: HANOVER

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: PROJECT NARRATIVE The molecular and cellular mechanisms by which inorganic arsenic exposure dramatically increases the risk of urothelial bladder cancer remain unclear. Using our recent discovery of a contractile zebrafish urinary bladder to leverage the many advantages of this model organism in studies of cancer genetics and environmental toxicology, we propose to develop the first zebrafish model of urothelial bladder neoplasia, and to apply single cell transcriptomics as a means to identify how inorganic arsenic interacts with oncogenic stimuli to accelerate bladder cancer initiation and progression.

PI_NAMEs: LEACH, STEVEN D (contact)

PROGRAM_OFFICER_NAME: JOHNSON, RONALD L

PROJECT_TERMS: Acceleration;Accounting;Address;Adult;Arsenic;Bladder;Bladder Urothelium;cancer genetics;cancer initiation;Cancer Model;cancer risk;candidate identification;cell type;Cells;Cessation of life;Chronic;contaminated drinking water;drinking water;Environment;Environmental Risk Factor;environmental toxicology;experience;Future;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Targeting;Genetic Transcription;Goals;Human;in vivo;Incidence;innovation;Institution;Knowledge;Malignant - descriptor;Malignant neoplasm of urinary bladder;Malignant Neoplasms;Mammals;model organism;Modeling;Molecular;Molecular Genetics;Mus;Neoplasms;neoplastic;neoplastic cell;Neoplastic Cell Transformation;New Hampshire;novel;Oncogene Activation;Oncogenes;Oncogenic;Population;premalignant;Prevention;Privatization;Productivity;Public Health;Recording of previous events;Research;Research Project Grants;Resolution;Risk;risk mitigation;Rural;Rural Population;single-cell RNA sequencing;Stimulus;Structure;System;Testing;Toxicogenetics;Toxicology;transcriptomics;tumor progression;Tumor Suppressor Genes;Tumor-Suppressor Gene Inactivation;Urothelial Cell;Urothelium;well water;Zebrafish;zebrafish development

PROJECT_TITLE: Cellular and Molecular Mechanisms of Arsenic-Induced Urothelial Bladder Cancer

STUDY_SECTION: EDD

STUDY_SECTION_NAME: Environmental Determinants of Disease Study Section [EDD]


ADMINISTERING_IC: GM

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: BALTIMORE

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE Only low-to-moderate efficacy is reported in clinical applications of magnetic fields such as transcranial magnetic stimulation (TMS) and magnetotherapy, despite the experimentally proven fact that magnetic fields influence the spin state of photo-generated radical pairs in many flavoproteins which determine the rate of downstream reactions governing important cellular behavior. Improvement in treatment efficacy is limited due to not knowing the molecular mechanism of magnetic modulation and to the incapability to measure effective intracellular magnetic fields, which are likely heterogeneous and not equivalent to the externally applied field of TMS or magnetotherapy. To surmount the technical difficulty in intracellular magnetic field measurement, we propose a genetically encoded magnetometer (GEM) in the form of recombinant protein, with which we will demonstrate that heterogenous intracellular magnetic fields can be mapped by expressing GEM in cells at unprecedented spatial resolution.

PI_NAMEs: CHEN, YUN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Address;ATP Synthesis Pathway;Binding;Biochemical Reaction;Biological;Biological Process;Biophysics;Calibration;cell behavior;Cell membrane;Cells;chronic pain;Circadian Rhythms;clinical application;cryptochrome 2;Cytoplasm;cytotoxicity;data acquisition;Data Analyses;data standards;density;design;Devices;Distant;DNA Repair;electric field;Electromagnetic Energy;Electromagnetic Fields;Electron Transport;Electrons;Environmental Impact;Epilepsy;Evaluation;Exposure to;fabrication;Flavoproteins;Fluorescence;fluorophore;Genes;Health;Heterogeneity;Homologous Gene;Image;improved;Infrastructure;Intracellular Membranes;Ion Channel;Ions;Life;Ligands;Light;Location;magnetic field;Magnetism;Magnetometries;Mammalian Cell;Maps;Measurement;Measures;mechanical force;Mental Depression;Methods;microwave electromagnetic radiation;migratory bird;Modeling;Molecular;nanodiamond;Neurons;Nitrogen;novel;optical spectra;particle;Permeability;Property;Proteins;Reaction;Recombinant Proteins;Recombinants;Reporting;Resolution;Role;Source;Temperature;tool;Transcranial magnetic stimulation;Treatment Efficacy;Validation;Vertebral column

PROJECT_TITLE: Genetically Encoded Magnetometer for Intracellular Dynamic Measurement

STUDY_SECTION: INN

STUDY_SECTION_NAME: Innovations in Nanosystems and Nanotechnology Study Section [INN]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Eye Disease and Disorders of Vision;Genetics;Precision Medicine

ORG_CITY: AUGUSTA

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: AUGUSTA UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Dry eye disease (DED) disproportionately affects females and displays variations among different racial backgrounds. The purpose of this proposal is to investigate the sex- and race-specific disparities in tear miRNAs and proteins, and their correlation with established DED subtypes and severity. Additionally, we will establish a comprehensive database that compiles the miRNAs and proteins detected in human tear fluid, providing a valuable resource to the scientific community.

PI_NAMEs: SHARMA, ASHOK  (contact);SHARMA, SHRUTI

PROJECT_TERMS: Accounting;Address;Affect;African American population;Age;American;aqueous;Asthenopia;Bioinformatics;Biological Markers;Biological Process;Characteristics;Circulation;Classification;Clinical;clinical application;Clinical assessments;clinical biomarkers;clinical implementation;Clinical Research;cohort;Collection;Communities;Complement;Data;Data Analyses;data reuse;data tools;data visualization;Databases;Development;Diagnosis;diagnostic strategy;diagnostic tool;Disease;disease diagnosis;disorder subtype;Disparity;Disproportionately impacts women;Dry Eye Syndromes;Dryness;effective therapy;Esthesia;Exhibits;Eye;eye dryness;Film;Freezing;Functional disorder;Gene Expression;High Prevalence;Human;improved;improved outcome;Individual;individualized medicine;insight;interest;Investigation;irritation;Life Style;Light;Link;Liquid substance;Machine Learning;Mass Spectrum Analysis;Measures;men;Messenger RNA;MicroRNAs;Molecular;Multiomic Data;Nature;novel;Nucleotides;ocular surface;Outcome;Pain;Pathway interactions;Patients;Pattern;personalized medicine;Persons;Play;Population Heterogeneity;potential biomarker;Prevalence;Process;Proteins;Proteomics;Race;racial population;Recording of previous events;Research;Research Personnel;Resistance;Resources;Role;Sampling;Severities;Severity of illness;sex;Sex Differences;Shotguns;Signs and Symptoms;Source;specific biomarkers;Specificity;Standardization;Symptoms;Systemic disease;tear proteins;Therapeutic Intervention;therapeutic target;Treatment Efficacy;treatment strategy;Untranslated RNA;Variant;Vision;Visualization;web site;Woman

PROJECT_TITLE: Sex-specific Influences on tear microRNAs in dry eye disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-S (02)]


ADMINISTERING_IC: AR

ED_INST_TYPE: UNIVERSITY-WIDE

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Infectious Diseases

ORG_CITY: MAYWOOD

ORG_NAME: LOYOLA UNIVERSITY CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE: Fracture-related infection (FRI) results in prolonged and costly treatments with unacceptably high treatment failure rates as a result of biofilm formation along the fracture implants. Bacteriophage therapy is a promising novel therapeutic with anti-biofilm activity, however many aspects of this therapy are poorly understood. Consequently, improved understanding of FRI pathophysiology and knowledge gained from animal models will allow for the creation of effective and reproducible FRI-bacteriophage protocols that will contribute to our ultimate goal of expanding treatment options not only in FRI but across the field of musculoskeletal infections.

PI_NAMEs: DOUB, JAMES B.;LEVACK, ASHLEY  (contact)

PROGRAM_OFFICER_NAME: WASHABAUGH, CHARLES H

PROJECT_TERMS: Address;Adjuvant Therapy;Affect;Animal Model;Antibiotics;Antibody Formation;Area;Bacteria;Bacteriophages;Blood Vessels;bone;bone prosthesis;Chronic;Clinical;Clinical Trials;Clonality;comparative efficacy;Complex;Complication;Confined Spaces;Data;Debridement;Development;effective therapy;efficacy evaluation;Ensure;Failure;Femur;Fracture;Functional disorder;genetic testing;Genomics;Goals;Implant;implant associated infection;improved;improved outcome;in vivo;Individual;Infection;intervention cost;intravenous administration;Knowledge;limb loss;Location;Metabolic;Methylene blue;Microbial Biofilms;Modeling;Morbidity - disease rate;mortality;Musculoskeletal;neutralizing antibody;novel;novel therapeutics;Operative Surgical Procedures;Orthopedics;Outcome;Pathway interactions;Patient-Focused Outcomes;Patients;Periprosthetic joint infection;Phenotype;pre-clinical research;Production;Protocols documentation;Rattus;Repeat Surgery;Reproducibility;Route;Safety;Scanning Electron Microscopy;septic;Series;Stains;Staphylococcus aureus;stem;Surgical Wound Dehiscence;Testing;therapeutic effectiveness;Tissues;Treatment Cost;Treatment Failure;Treatment Protocols;treatment strategy;Visualization;Work

PROJECT_TITLE: The utility of bacteriophage therapy in fracture-related infections: Preclinical research needed to create effective and reproducible treatment protocols

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: The purpose of this project is to understand the evolutionary dynamics between phage and bacteria as they undergo adaptation and counteradaptation to live/die pressures. By determining the mutations that drive bacterial resistance or phage killing, it will inform clinical practice through the selection of phage for cocktails that anticipate and thus prevent resistance (and improve therapeutic outcomes).

PI_NAMEs: MARESSO, ANTHONY W (contact);RUCHHOEFT, PAUL

PROGRAM_OFFICER_NAME: XU, ZUOYU

PROJECT_TERMS: Address;Adopted;alternative treatment;Antibiotic Resistance;Antibiotic susceptibility;Antibiotics;Automobile Driving;Bacteria;Bacterial Infections;bacterial resistance;Bacteriophages;Biological Adaptation;Bioreactors;Caring;Categories;Cessation of life;Chemicals;Chronic;Clinical;clinical practice;Clinical Trials;Coculture Techniques;Collection;conventional therapy;cost;Directed Molecular Evolution;Disease;Disincentive;Drug resistance;Dryness;dynamical evolution;Engineering;Escherichia coli;Escherichia coli drug resistance;Event;Evolution;exhaust;Exposure to;falls;Frequencies;Future;Genetic;genome sequencing;Growth;Healthcare Systems;Hour;improved;Infection;Intestines;Knowledge;Life;Life Cycle Stages;logarithm;Lytic Virus;Maps;Measurable;Medical;Methods;Morbidity - disease rate;mortality;Multi-Drug Resistance;mutant;Mutate;Mutation;next generation;novel;novel therapeutic intervention;Nutritional status;permissiveness;Persons;Pharmaceutical Preparations;Population;Predisposition;pressure;prevent;product development;Production;Reproducibility;Resistance;Resistance development;resistant strain;Resources;Running;Sepsis;Stress;System;Temperature;Testing;Therapeutic;therapy outcome;Time;Training;Treatment outcome;trend;United States Food and Drug Administration;Variant;Viral;Virus;whole genome;Work

PROJECT_TITLE: Phage-Bacteria Evolution via Next-Generation Phage Bioreactors

STUDY_SECTION: GVE

STUDY_SECTION_NAME: Genetic Variation and Evolution Study Section[GVE]


NIH_SPENDING_CATS: Breast Cancer;Cancer;Women's Health Research

ORG_CITY: GAINESVILLE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF FLORIDA

ORG_STATE: FL

PHR: NARRATIVE PTP1B, a non-receptor–type oncogenic PTP, also known as PTPN1, is involved in growth factor signaling. The PTP1B gene is frequently amplified in ovarian, gastric, prostate, and breast cancers and correlates with poor prognosis. However, despite the attractiveness of PTP1B as a therapeutic target, the development of drug-like inhibitors of this enzyme has proven difficult, primarily due to low cell permeability and a lack of selectivity towards other PTPs. The goal of this proposal is to develop charge neutral inhibitors that specifically target the oxidized form of PTP1B (PTP1B- ox), which exists principally in the disease state.

PI_NAMEs: CARROLL, KATE SUZANNE (contact)

PROGRAM_OFFICER_NAME: COVELL, DAVID G

PROJECT_TERMS: Acceleration;Active Sites;AKT Signaling Pathway;alpha helix;Amides;Antibodies;Antineoplastic Agents;Apoptosis;Biological Availability;Breast Epithelial Cells;Catalytic Domain;Cell Cycle Arrest;cell growth;Cell Proliferation;Cells;Cellular Assay;Charge;Chemistry;combinatorial;Disease;drug development;drug discovery;Energy Metabolism;Enzyme Inhibitor Drugs;Epithelium;ERBB2 gene;Etiology;Family;Foundations;Future;Genes;Genetic;Goals;Growth Factor;Human;human disease;Immunoglobulin Fragments;inhibitor;innovation;insight;Insulin;interest;Invaded;knock-down;Knock-out;Knockout Mice;Leptin;Libraries;Lymphomagenesis;Malignant Breast Neoplasm;Malignant neoplasm of ovary;Malignant neoplasm of prostate;Malignant Neoplasms;malignant stomach neoplasm;Mammary Neoplasms;Mammary Tumorigenesis;MAP Kinase Gene;Mediating;member;Mesenchymal;Metabolic Diseases;Metabolism;Metastatic Neoplasm to the Lung;migration;mimetics;Molecular Conformation;Mouse Mammary Tumor Virus;mouse model;Nature;Neoplasm Metastasis;Non-Small-Cell Lung Carcinoma;Oncogenic;oxidation;Oxidation-Reduction;Periodicity;Permeability;pharmacologic;PIK3CG gene;polyketides;Process;Prognosis;protein tyrosine phosphatase 1B;Proteins;PTPN1 gene;Reactive Oxygen Species;Regulation;Research Personnel;response;Role;screening;sensor;Signal Pathway;Signal Transduction;Sulfenic Acids;Therapeutic;therapeutic target;Tissues;TP53 gene;tumor;Tumor Suppressor Proteins

PROJECT_TITLE: Targeting Oxidized PTP1B for Anticancer Drug Discovery

STUDY_SECTION_NAME: Special Emphasis Panel[ZCA1 TCRB-J (J2)]


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

PHR: PROJECT NARRATIVE This research program aims to advance our understanding of ADP-ribosylation—a recently discovered DNA modification implicated in critical biological processes, including DNA repair, gene regulation, and pathogen defense. By developing new tools to study this modification, we can deepen our understanding of how our bodies protect against diseases, including infections and cancer. Ultimately, our work could pave the way for novel diagnostic tools and therapeutic strategies, potentially enhancing public health outcomes.

PI_NAMEs: LEUNG, ANTHONY K L (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Acinetobacter baumannii;adduct;Adenine;Adenosine Diphosphate Ribose;ADP Ribose Transferases;ADP ribosylation;analog;anti-toxin;Antineoplastic Agents;Bacteria;Bacterial DNA;Bacterial Toxins;Bacteriophages;base;Binding Sites;Biological Assay;Biological Process;Biology;Biosensor;Butterflies;Cells;Chemical Structure;Chemistry;Collaborations;Data;Data Analyses;Detection;Development;diagnostic tool;Disease;DNA;DNA Modification Process;DNA Repair;DNA-Directed DNA Polymerase;Drug Targeting;Enzymes;Epigenetic Process;Escherichia coli;Foundations;Gene Expression Regulation;Genetic Fingerprintings;Genome;genome-wide;Genomic DNA;Genomics;Goals;Guanine;Healthcare;Human;improved;In Vitro;Individual;Infection;innovative technologies;inorganic phosphate;Insecta;insight;Integral Membrane Protein;Investigation;Knowledge;Label;Life;Machine Learning;Malignant Neoplasms;Maps;Measures;Mediating;Methods;Microbe;Modeling;Modification;Monitor;Mutagenesis;Mycobacterium tuberculosis;nanopore;novel diagnostics;novel strategies;nucleobase;Oligonucleotides;Organism;Outcome;Parasites;pathogen;Pathogenicity;Pattern;Plants;Play;Post-Translational Protein Processing;prevent;Process;Production;programs;Proteins;Pseudomonas aeruginosa;Public Health;Radioactive;Reaction;recruit;Research;RNA;Role;Sepharose;Site;stem;Stretching;System;Techniques;Technology;Testing;Therapeutic;Thymine;tool;Toxin;viral DNA;Virion;Virus;whole genome;Work

PROJECT_TITLE: DEVELOP GENOMEWIDE TECHNOLOGY TO PROFILE DNA ADP-RIBOSYLATION

STUDY_SECTION: GCAT

STUDY_SECTION_NAME: Genomics, Computational Biology and Technology Study Section[GCAT]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging

ORG_CITY: ATLANTA

ORG_DEPT: CHEMISTRY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: PROJECT NARRATIVE This proposal aims to understand how spatial and temporal changes in mitochondria impact physiological states throughout the lifespan of animals. By using advanced imaging techniques and an in vivo genetic model, we propose to directly observe and analyze the location, morphology, contacts, and physiological states of individual mitochondria in different tissues and subcellular areas during aging. This research has the potential to enhance our understanding of aging and mitochondrial biology and lead to the development of novel strategies for treating diseases associated with mitochondrial dysfunction.

PI_NAMEs: CHEN, WEI-WEN  (contact);CICERONE, MARCUS T;HAN, SUNG MIN

PROGRAM_OFFICER_NAME: BARRETT, PAUL JOHN

PROJECT_TERMS: Address;Age;age group;age related;Aging;Alzheimer's Disease;Alzheimer's disease model;Animals;Area;Biological Models;Biology;Caenorhabditis elegans;Cell Physiology;cell type;Cells;Cellular biology;Characteristics;Chemicals;Data;Detection;Development;Disease;energy balance;Energy Metabolism;Environment;Epidermis;Exhibits;fitness;fluorescence imaging;fluorescence lifetime imaging;Fluorescence Microscopy;Fluorescent Dyes;Functional disorder;Genetic Models;Germ Lines;grasp;Heterogeneity;Homeostasis;human old age (65+);Image;imaging approach;Imaging Techniques;improved;in vivo;in vivo imaging;in vivo Model;Individual;innovation;insight;Intestines;Ions;Label;life span;Link;Lipids;Location;Machine Learning;Maps;Metabolic;Metabolism;Mitochondria;mitochondrial dysfunction;model organism;Modeling;Morphology;Muscle;Mutation;Nematoda;Neurons;novel;novel strategies;Organelles;Organism;particle;Physiologic Monitoring;Physiological;Physiology;Play;Positioning Attribute;Publishing;Regulation;Reporter;Research;Role;Shapes;Signal Pathway;Signal Transduction;Stains;Structure;Synapses;Techniques;Tissues;tool;two-photon;Variant

PROJECT_TITLE: Investigating spatial and temporal heterogeneity in mitochondria during aging using in vivo high-content chemical imaging

STUDY_SECTION: NOMD

STUDY_SECTION_NAME: Neural Oxidative Metabolism and Death Study Section[NOMD]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Heart Disease;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: PITTSBURGH

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: PROJECT NARRRATIVE Out-of-hospital cardiac arrest is a significant public health concern, affecting approximately 347,000 Americans each year, with a survival rate to hospital discharge as low as 9.0%. Although Black and Hispanic patients exhibit lower survival rates than White patients, the reasons for this health inequity remain unclear. This proposal aims to evaluate racial and ethnic differences in emergency medical services practices during cardiac arrests in order to identify specific areas in prehospital care that can be improved to mitigate this health inequity following out-of-hospital cardiac arrest.

PI_NAMEs: OKUBO, MASASHI  (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: 911 call;Address;Adult;Affect;American;Area;authority;Automated External Defibrillator;black patient;Black race;Cardiac Catheterization Procedures;Cardiopulmonary Resuscitation;Caring;Chest;Clinical;Comprehension;Data Set;Death Rate;Disparity;Distress;Education;Electric Countershock;Emergency medical service;Ensure;Epidemiology;Epinephrine;ethnic difference;ethnic disparity;Ethnic Origin;Evaluation;Exhibits;experience;functional outcomes;Goals;hazard;Health Disparities Research;health inequalities;Heart Arrest;Hispanic;Home;Hospitals;Human Resources;implicit bias;improved;Individual;intersectionality;Intervention;Investigation;Knowledge;Link;Location;Measures;Mediating;Mediation;medication administration;Meta-Analysis;Modeling;mortality;North America;Odds Ratio;out-of-hospital cardiac arrest;Outcome;outcome disparities;Patient-Focused Outcomes;Patients;Pre-hospitalization care;premature;prospective;Public Health;Race;racial difference;racial disparity;Registries;Reporting;Research;Resuscitation;Role;service intervention;sex;Shock;Site;Statistical Models;Stroke;Survival Analysis;survival outcome;Survival Rate;System;systematic review;Time;Trauma;United States

PROJECT_TITLE: Racial and Ethnic Differences in Emergency Medical Services Interventions for Out-of-Hospital Cardiac Arrest

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ORG_CITY: NEW YORK

ORG_NAME: COLUMBIA UNIVERSITY HEALTH SCIENCES

ORG_STATE: NY

PHR: PROJECT NARRATIVE Reliable biomarker assays could greatly improve diagnosis of Irritable Bowel Disorder and its various subtypes. This proposal aims to develop a method to identify nucleic acid biomarkers for IBD directly from stool samples using healthy and IBD associated specimens. Findings from this work will lead to better clinical diagnosis and subtyping of IBD, and more sensitive measurement of response to therapy, all toward the goal of improving patient outcome and reducing clinical cost and resources.

PI_NAMEs: WANG, HARRIS H (contact)

PROGRAM_OFFICER_NAME: HUDSPETH, KELLY

PROJECT_TERMS: Abdomen;Adult;Affect;Algorithms;American;anti-depressive agents;Antibiotics;Biological Assay;Biological Markers;biomarker discovery;Blood Tests;Celiac Disease;cell type;Cells;Chronic;Chronic diarrhea;Clinical;clinical biomarkers;clinical decision-making;clinical diagnosis;clinical subtypes;cohort;Colonoscopy;Colorectal Cancer;Consultations;cost;Data;Defecation;Development;Diagnosis;Diagnostic;Diarrhea;Disease;Disease Management;DNA;Epithelial Cells;Etiology;Exclusion;Feces;Functional disorder;Gastroenterologist;gastrointestinal;gastrointestinal epithelium;Gene Expression;Genes;Genetic Materials;Goals;gut microbes;gut microbiome;gut microbiota;Happiness;Health Care Costs;Healthcare;Heterogeneity;Home;host microbiome;host-microbe interactions;Housekeeping;Human;Hypersensitivity;Immune;Impairment;improved;Infection;Inflammatory Bowel Diseases;Institution;Intervention;Intestines;Intrinsic drive;Irritable Bowel Syndrome;Link;Logistic Regressions;Machine Learning;Measurement;Medical Care Costs;Metabolic;Metagenomics;Methods;microbiome;microbiome sequencing;microbiome signature;microbiota;microbiota profiles;Microscopic Colitis;Modeling;mortality risk;Motility;Nature;novel;Nucleic Acids;Outcome;outcome prediction;Pathway interactions;Patient-Focused Outcomes;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;predictive modeling;Procedures;Quality of life;Recommendation;Research;Resources;rifaximin;RNA;Specimen;stool sample;Symptoms;Testing;Time;tool;transcriptome sequencing;treatment response;Validation;Variant;Visceral;Work

PROJECT_TITLE: Profiling diarrhea-predominant irritable bowel syndrome (IBS-D) using stool-based RNAs

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: CHAMPAIGN

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN

PHR: PROJECT NARRATIVE The preclinical model studies have led to many fundamental discoveries, understanding of normal and abnormal human systems, and transformed human health and medicine. The mouse models have been influential in developing novel vaccines, adjuvants, therapies, and immunotherapies. This proposal proposes to generate a novel strain mouse that helps develop the cell-specific, tailored, targeted, and interventional therapies to enhance the immunity against pulmonary fungal infections, understand the mechanisms of immune responses to pulmonary pathogens, bolster fungal vaccine efficacy, and develop therapeutic strategies against aggressive cancers.

PI_NAMEs: NANJAPPA, SOMASHEKARAPPA GOWDA (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Ablation;adaptive immune response;Address;Adhesives;Adjuvant;American Lung Association;anti-fungal agents;Apoptosis;Attention;Autoimmunity;Backcrossings;Bacterial Infections;Binding;Biological Models;Biomedical Research;Blastomyces;Bone Marrow;cancer cell;Candida;Carcinoma;CD43 molecule;CD8-Positive T-Lymphocytes;Cell Death;Cell Lineage;Cell Physiology;cell type;Cells;Cessation of life;Chimera organism;climate change;COVID-19 pandemic;CRISPR/Cas technology;Data;design;E-Selectin;Escherichia coli heat-labile toxin;experimental study;Funding;fungal pneumonia;Fungal Vaccines;Galectin 1;Generations;Genus Mycobacterium;Glean;Grant;Habitats;Health;Hematopoietic;Histoplasma;Host Defense Mechanism;Human;Immune;Immune response;Immunity;immunological synapse;Immunotherapeutic agent;Immunotherapy;individualized medicine;Infection;Influentials;Influenza A virus;Innate Immune Response;insight;Intercellular adhesion molecule 1;Knockout Mice;Knowledge;Ligands;LoxP-flanked allele;Lung;lung pathogen;Lymphoid;Malaria;Malignant Neoplasms;Medical;Medicine;Microbe;microbial products;mortality;mouse model;Mouse Strains;Mus;Mycoses;Myelogenous;novel;novel vaccines;Outcome;Output;Parasitic infection;Patients;Pattern recognition receptor;Phase;Phenotype;Population;Pre-Clinical Model;Predisposition;programs;Property;Public Health;receptor;Reproducibility;Research;respiratory;response;Risk;Role;sialoadhesin;Study models;System;T cell response;T-Lymphocyte;targeted treatment;text searching;Therapeutic;Therapeutic Intervention;trafficking;Transplantation;Trypanosoma cruzi;tumor;Vaccination;vaccine development;vaccine efficacy;vaccine response;Vaccines;vector;Virus Diseases;Wiskott-Aldrich Syndrome;Yeasts

PROJECT_TITLE: Generation and characterization of CD43-floxed mice for conditional ablation in hematopoietic cells and T cells in immunity against pulmonary fungal infections

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


NIH_SPENDING_CATS: Brain Disorders;Complementary and Integrative Health;Dietary Supplements;Genetics;Human Genome;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Nutrition;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Prevention;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: SYRACUSE

ORG_DEPT: BIOLOGY

ORG_NAME: SYRACUSE UNIVERSITY

PHR: NARRATIVE / RELEVANCE Disruptions in neuronal development and connectivity within the neocortex, the area of the brain responsible for high cognitive function, are found in many neurodevelopmental disorders, including autism spectrum disorders, intellectual disability, and schizophrenia. What causes this atypical development is still poorly understood, but likely includes a combination of genetic, epigenetic, and environmental factors, including maternal nutrition. We propose to employ a novel model system to investigate the mechanisms underlying how in utero exposure to a sufficient versus supplemented folic acid diet can modify neocortical development, in the context of a fixed genetic susceptibility to atypical neurodevelopment.

PI_NAMEs: MACDONALD, JESSICA L. (contact)

PROGRAM_OFFICER_NAME: OREILLY, JULIA JIAQI

PROJECT_TERMS: Antibodies;Area;autism spectrum disorder;Axon;Behavior;Behavioral;Biological Models;Brain;Cell Cycle;Characteristics;Cilia;cognitive function;Complex;conditional knockout;Custom;Data;Defect;Development;Diet;DNA Methylation;DNA methylation profiling;Embryo;embryonic stem cell;Environmental Risk Factor;EP300 gene;Epigenetic Process;epigenome;Equilibrium;Exposure to;Fluorescence-Activated Cell Sorting;Folic Acid;folic acid supplementation;Functional disorder;Future;gene environment interaction;Gene Expression;Gene Modified;gene regulatory network;Gene Silencing;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic study;Genetic Transcription;High Fat Diet;histone acetyltransferase;Human;in utero;In Vitro;in vivo;Intellectual functioning disability;Investigation;Knockout Mice;Lead;Left;loss of function;methylome;Modification;Molecular Profiling;Monozygotic twins;mother nutrition;Neocortex;neocortical;nerve stem cell;Neural Tube Closure;neurodevelopment;Neurodevelopmental Disorder;neuron development;Neuronal Differentiation;Neurons;neuropsychiatric disorder;novel;Pathway interactions;Pattern;Phenotype;Play;postnatal;prenatal exposure;progenitor;programs;Proliferating;Prosencephalon;recruit;Regulation;Risk;Role;Schizophrenia;stem cell differentiation;stem cell proliferation;stem cells;Testing;Therapeutic;transcriptome;transcriptome sequencing;Work

PROJECT_TITLE: Unraveling the interplay between the transcriptional co-regulator Cited2 and maternal folic acid in the regulation of neocortical development

STUDY_SECTION: NCF

STUDY_SECTION_NAME: Neurogenesis and Cell Fate Study Section[NCF]


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cardiovascular;Clinical Research;Estrogen;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Heart Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Precision Medicine;Transplantation;Women's Health Research

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE Women with severe aortic stenosis face delayed diagnosis, undertreatment, and higher mortality rates compared to men, highlighting the need for improved diagnostics and treatment strategies for female patients. By integrating innovative medical image processing and computational modeling methods, our project aims to gain sex-differentiating insights into cardiac remodeling and dysfunction in severe aortic stenosis among women, with the goal of enhancing treatment outcomes. By providing valuable insights, our research serves as a basis for guiding clinicians in patient selection, optimizing surgical timing, and ultimately enhancing survival rates for female patients with aortic stenosis in future.

PI_NAMEs: RIKHTEGAR NEZAMI, FARHAD  (contact)

PROGRAM_OFFICER_NAME: EVANS, FRANK

PROJECT_TERMS: Affect;Age;Anatomy;aortic valve;aortic valve disorder;aortic valve replacement;Aortic Valve Stenosis;Back;Bioinformatics;Calcium;Cardiac;Cardiovascular Diseases;care seeking;Caring;Characteristics;Clinical;clinical diagnosis;clinical imaging;Clinical Management;clinical predictors;clinical risk;Complex;Computer Models;computerized tools;Computing Methodologies;convolutional neural network;Death Rate;Decision Making;deep learning;Development;Diagnosis;Diagnostic;diagnostic strategy;Diameter;Disease;Disparity;Early Diagnosis;Effectiveness;Elderly;Engineering;Event;Excess Mortality;Exhibits;experience;Face;Female;Fibrosis;Finite Element Analysis;Functional disorder;Future;General Population;Geometry;Goals;Grant;Guidelines;Hypertrophy;Image;image processing;improved;indexing;innovation;insight;interest;Intervention;Left;Left ventricular structure;Link;male;mathematical methods;Mathematics;Measures;Medical Imaging;men;Methods;Modeling;Monitor;neural network;novel strategies;Operative Surgical Procedures;Outcome;outcome prediction;Patient imaging;Patient Selection;Patient-Focused Outcomes;Patients;Pattern;Population;post intervention;Postoperative Period;Predictive Value;Prevalence;Process;Prognosis;Property;Reporting;Research;response;Risk Assessment;risk stratification;sex;Sex Differences;Sex Differentiation;sex disparity;sexual dimorphism;shape analysis;Shapes;survival outcome;Survival Rate;Symptoms;Techniques;Technology;Therapeutic;Tissues;tool;Training;treatment optimization;Treatment outcome;treatment planning;treatment risk;treatment strategy;Ventricular;Woman;women patients;women's outcomes;women's treatment;Work;X-Ray Computed Tomography

PROJECT_TITLE: Leveraging Sexual Dimorphism to Predict Cardiac Remodeling and Enhance Treatment in Women with Severe Aortic Stenosis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-J (96)]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Microbiome

ORG_CITY: SAINT LOUIS

ORG_DEPT: PEDIATRICS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE B. fragilis is a leading microbial reservoir of antibiotic drug resistance, most concerning of which is through expression of metallo-b-lactamases (MBL). At present, there is a gap in knowledge on how MBL expression is preserved within the native colonic niche of B. fragilis. We have identified a novel bacterial toxin that facilitates competition of MBL-expressing B. fragilis. Understanding the molecular mechanisms by which MBL-expressing B. fragilis gain access to and preserve the colonic niche is expected to inform an understanding of how to combat spread of drug resistance.

PI_NAMEs: BUBECK WARDENBURG, JULIANE  (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Amino Acid Sequence Homology;Amino Acids;Anaerobic Bacteria;Antibiotic Resistance;antimicrobial;Antimicrobial Resistance;bacterial genetics;Bacterial Toxins;Bacteroides;Bacteroides fragilis;beta-Lactam Resistance;beta-Lactamase;beta-Lactams;carbapenem resistance;Carbapenems;Cephalosporins;Clinical;Collection;Colon;colon microbiome;combat;Data;Death Rate;Disease;Dissection;Drug resistance;dysbiosis;Engineering;Ensure;Enteral;Enzymes;Event;Exhibits;Extended-spectrum β-lactamase;Family;Fright;Genes;Genetic;genetic analysis;Genetic Determinism;Genetic Screening;genetic variant;genomic locus;Genomics;Goals;Growth;gut microbiome;gut microbiota;Health;Human;human microbiota;Immunity;Impairment;In Vitro;in vivo;Infection;inhibitor;Intestines;Knowledge;Lactamase;Life;Maintenance;Mediating;Microbe;microbial;Modeling;Modernization;Molecular;Monobactams;mouse model;Mus;mutant;neonate;novel;Nutrient;Nutrient availability;Organism;pan-genome;Pathology;Penicillin Resistance;Penicillins;Phenotype;Phylogenetic Analysis;Play;Positioning Attribute;preservation;Prevalence;Probiotics;Proteins;repository;Resistance;resistance gene;resistant strain;Role;Sepsis;Series;Serine;Shapes;Specificity;success;System;Tissues;Toxin;trait;uptake;Vertical Transmission;Zinc

PROJECT_TITLE: Novel Bacteroides fragilis Competition Factor in Carbapenem-Resistant Strains

STUDY_SECTION: IMII

STUDY_SECTION_NAME: Interspecies Microbial Interactions and Infectious Study Section[IMII]


NIH_SPENDING_CATS: Organ Transplantation;Transplantation

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: PROJECT NARRATIVE  These studies seek to establish a new cost-efficient scalable approach to measure the cell-to-cell variability in the function of regulatory T cells (Treg), a current unmet challenge in the field. We will modify a small-molecule glutathione (GSH) biosensor recently developed by our group and use it to test the hypothesis that cell-to-cell differences in GSH homeostasis within Tregs underlies the heterogeneity in Treg suppressive capacity and to provide proof-of-concept that this approach can capture clinically relevant heterogeneity in circulating Treg from kidney transplant recipients treated with anti-IL6-R antibody (tocilizumab).

PI_NAMEs: CRAVEDI, PAOLO ;FRIBOURG, MIGUEL  (contact)

PROGRAM_OFFICER_NAME: KEHN, PATRICIA J

PROJECT_TERMS: Antibodies;Antioxidants;Behavior;Binding;Biological Assay;Biosensor;Cells;Chemicals;clinical application;clinically relevant;cost efficient;Cysteine;Data;design;Equilibrium;Eragrostis;Fluorescence;Genetic Transcription;Glutamate-Cysteine Ligase;Glutathione;Glycolysis;Heterogeneity;high reward;high risk;Homeostasis;IL6 gene;Interleukin 6 Receptor;Kidney Transplantation;Maps;Measures;Metabolic;Metabolic Pathway;Monoclonal Antibodies;organ transplant recipient;Outcome;oxidation;Oxidation-Reduction;Oxidative Phosphorylation;Oxidative Stress;Oxidative Stress Induction;Pathway interactions;Patients;Phenotype;phenotypic biomarker;preservation;prevent;Property;Publishing;Randomized Controlled Clinical Trials;Reaction;Regulation;Regulatory T-Lymphocyte;Research Design;response;Sampling;sensor;small molecule;standard of care;Stimulus;System;T cell response;T-Cell Activation;T-Lymphocyte;Techniques;Testing;tocilizumab;tool;translational potential;Transplant Recipients;Transplantation

PROJECT_TITLE: Redox homeostasis to capture regulatory T cell heterogeneity in transplant

STUDY_SECTION: TTT

STUDY_SECTION_NAME: Transplantation, Tolerance, and Tumor Immunology Study Section[TTT]


ORG_CITY: CHICAGO

ORG_NAME: RUSH UNIVERSITY MEDICAL CENTER

PHR: PROJECT NARRATIVE___________________________________________________________________ Periprosthetic joint infection (PJI) is the most common cause of acute joint replacement failure and contributes to substantial morbidity, mortality, and hospital costs following joint replacement surgery. Bacterial biofilm formation makes PJI extremely resistant to antibiotics and the host immune response, which leads to high PJI treatment failure rates. We will test a biofilm disrupting antibody (anti-DNABII monoclonal antibody) as a method to prevent and treat PJI in a well validated mouse model of PJI for enhancement of PJI prevention and treatment strategies.

PI_NAMEs: HAMILTON, JOHN L (contact);WIMMER, MARKUS ANTON

PROGRAM_OFFICER_NAME: WANG, XIBIN

PROJECT_TERMS: Acute;adverse outcome;Amputation;Animal Model;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Antibodies;antibody test;antimicrobial;Bacteria;Bacterial Infections;Bacterial Pneumonia;Binding;Biological Assay;Biomass;care episode;Cells;Cessation of life;Chronic;Clinical;Clinical Research;Complication;Control Groups;cost;Data;Death Rate;Debridement;DNA;DNA Binding;Drops;efficacy validation;environmental stressor;Excision;experimental group;Experimental Implants;experimental study;extracellular;Extracellular Matrix;Failure;Femur;Future;Generations;Grant;Hospital Costs;Hour;Human;Immune;Immune response;Immune system;Implant;implant coating;implant material;Implantation procedure;In Vitro;in vitro testing;in vivo;Incidence;indexing;Infection;Infection prevention;Intra-Articular Injections;Investigation;joint function;Joints;Lipids;loss of function;Lung infections;Malignant Neoplasms;Mediating;Methods;Microbial Biofilms;Modeling;Monitor;Monoclonal Antibodies;Morbidity - disease rate;mortality;mortality risk;mouse model;Mus;novel;Operative Surgical Procedures;Organ;Orthopedics;Otitis Media;Outcome;Pathogenesis;Patients;Perioperative;Periprosthetic joint infection;Phase I Clinical Trials;Pneumonia;pre-clinical;preclinical study;prevent;Prevention;Prevention strategy;Prospective Studies;Prosthesis;Proteins;Recurrence;Replacement Arthroplasty;Reporting;resazurin;Resistance;Resolution;Risk;safety testing;Second Look Surgery;Site;Staphylococcus aureus;Staphylococcus aureus infection;Structure;success;Surface;Testing;Therapeutic;Time;Tissues;Titanium;Toxic effect;Treatment Failure;treatment strategy;Vancomycin

PROJECT_TITLE: Use of Bacterial Biofilm Disrupting Antibodies to Prevent and Treat Periprosthetic Joint Infection

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


NIH_SPENDING_CATS: Cardiovascular;Contraception/Reproduction;Genetics;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Women's Health Research

ORG_CITY: AUSTIN

ORG_DEPT: OBSTETRICS & GYNECOLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: NARRATIVE While defective trophoblast lineage differentiation is one of the major causes of human pregnancy- related conditions such as preeclampsia (PE), underlying molecular mechanisms underlying PE have been elusive. By defining novel key regulators directly influencing the pathophysiology of PE and understanding their modes of action on trophoblast differentiation, our proposed studies aim to provide diagnostic tools and therapeutic means to improve human pregnancy outcomes.

PI_NAMEs: KIM, JONGHWAN  (contact)

PROGRAM_OFFICER_NAME: ILEKIS, JOHN V

PROJECT_TERMS: Affect;Beds;Biological Assay;Biological Models;Biotinylation;Caring;Cessation of life;Clustered Regularly Interspaced Short Palindromic Repeats;CRISPR-mediated transcriptional activation;Defect;Development;diagnostic tool;differentiation in vitro;Doxycycline;Eclampsia;Endoglin;Enhancers;Epigenetic Process;Expression Profiling;fetal;Fetal health;Functional disorder;Future;gain of function;Gene Expression;Gene Expression Profile;Gene Expression Profiling;gene regulatory network;Genes;Genetic Markers;Genetic Transcription;Goals;Growth;Healthcare;Human;Hyperactivity;Hypertension;Impairment;implantation;improved;in vivo;Invaded;Knock-out;Lighting;Link;Maps;Maternal Health;Modeling;Molecular;Monitor;Morbidity - disease rate;mortality;novel;novel diagnostics;Outcome;pathophysiology of preeclampsia;Perinatal;Phenotype;Placenta;Placentation;postnatal period;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Outcome;Premature Birth;prevent;programs;promoter;Protein Secretion;Proteins;Proteinuria;recruit;Role;Spiral Artery of the Endometrium;stem cell differentiation;stem cell model;Stroke;Study models;Syncytiotrophoblast;System;Testing;Therapeutic;transcription factor;transcription factor USF;transcriptome;trophoblast;trophoblast stem cell;Up-Regulation;Validation;Vascular Diseases;Vascular Endothelial Growth Factor Receptor-1;Villous;Woman;Work

PROJECT_TITLE: Elucidation of the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Arthritis;Autoimmune Disease

PHR: Project Narrative This project plans to study the pathogenesis of human diseases that are associated with HLA-B27, such as ankylosing spondylitis and anterior uveitis. Based on newly published information, they hypothesize that CD8+ T cells respond to bacterial challenges which then result in their attack of normal tissues due to cross-reactivity. Such detailed studies will require the development of a mouse model. Here the investigator presents plans to develop such a model by producing mice expressing the relevant human molecules that include HLA-B27, a relevant T cell receptor and other molecules required for optimal T cell responses.

PI_NAMEs: YOKOYAMA, WAYNE M. (contact)

PROGRAM_OFFICER_NAME: MAO, SU-YAU

PROJECT_TERMS: Affect;Alleles;Animal Model;Ankylosing spondylitis;Anterior uveitis;Antigen Presentation;Antigen-Presenting Cells;Antigens;Autoimmune Diseases;beta-2 Microglobulin;CD8-Positive T-Lymphocytes;CD8B1 gene;Cells;Clinical;Clonal Expansion;Collaborations;Complementary DNA;Complication;cross reactivity;Crystallography;Data;Development;Disease;Eye;Foundations;Genes;genome wide association study;HLA-B27 Antigen;Human;human disease;Immune response;Individual;International;Joints;Knock-in;Knowledge;Laboratories;Major Histocompatibility Complex;Modeling;Modification;mouse development;mouse model;Mus;Normal tissue morphology;Pathogenesis;Patients;Peptides;Proteins;Publishing;Reporter;Research Personnel;response;Rodent Model;Role;Spondylarthropathies;T cell response;T-Cell Receptor;T-Lymphocyte;Testing

PROJECT_TITLE: Animal model of HLA-B27 disease

STUDY_SECTION: ACTS

STUDY_SECTION_NAME: Arthritis, Connective Tissue and Skin Study Section[ACTS]


ADMINISTERING_IC: EB

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: BIOMEDICAL ENGINEERING

PHR: PROJECT NARRATIVE Pulse oximetry is used to guide care for critically ill patients, but there is are concerning reports that show racial bias in pulse oximeters may overestimate blood oxygen levels in darkly pigmented patients who actually have low oxygen levels, which can cause harm by delaying or preventing timely respiratory support to these patients. The goal of this proposal is to evaluate sources of bias caused by skin pigmentation and blood perfusion, and to develop a new pulse oximeter that accurately provides blood oxygen estimates for all patients, regardless of skin color.

PI_NAMEs: O'BRIEN, CHRISTINE M (contact);SHMUYLOVICH, LEONID

PROGRAM_OFFICER_NAME: ANDERSON, AFROUZ AZARI

PROJECT_TERMS: absorption;Animals;Aphorisms;Blood;Blood flow;blood perfusion;Calibration;Caring;Critical Care;Critical Illness;Custom;Darkness;Data;deoxyhemoglobin;Devices;Diameter;Ear;Ensure;Error Sources;Evaluation;Exhibits;Face;Family suidae;Fingers;Goals;health disparity;health inequalities;Healthcare Systems;Hypoxemia;Hypoxia;in vivo;indexing;Injections;Laser-Doppler Flowmetry;Life;marginalized community;Measures;Melanins;novel;Optics;Oxygen;Patients;Perfusion;Peripheral;Persons;Physiologic pulse;Physiological;Pigmentation physiologic function;Population Heterogeneity;porcine model;prevent;Property;Pulse Oximetry;racial bias;Reporting;respiratory;sensor;Short Waves;Signal Transduction;Skin;skin color;Skin Pigmentation;Source;Spottings;standard of care;System;Technology;Testing;Tissues;transmission process;Variant;Vasoconstrictor Agents;Vasodilator Agents;Work

PROJECT_TITLE: Mitigating errors in pulse oximeter-derived estimates of oxygenation and perfusion caused by skin pigmentation with a shortwave infrared pulse oximeter

STUDY_SECTION: ISD

STUDY_SECTION_NAME: Instrumentation and Systems Development Study Section[ISD]


NIH_SPENDING_CATS: Genetics;Infectious Diseases

ORG_CITY: STILLWATER

ORG_NAME: OKLAHOMA STATE UNIVERSITY STILLWATER

ORG_STATE: OK

PHR: Project Narrative It is in a virus’ best biological interest to protect the cells it has infected from simultaneous infection by other viruses. This competition between viruses has led to the evolution of defense systems and means to overcome them. This proposal studies this phenomenon in microviruses, which are among the most abundant viruses infecting bacteria in the human gut, and which might have evolved entirely novel ways to defend against other viruses.

PI_NAMEs: KIRCHBERGER, PAUL  (contact)

PROJECT_TERMS: Animals;arms race;Bacteria;Bacteriophages;Biological;Biological Assay;Biology;Cells;co-infection;comparative genomics;Comparative Study;Complementarity Determining Regions;Conflict (Psychology);Cross Infection;Cytoprotection;Defense Mechanisms;Disease;DNA;Double Stranded DNA Virus;ds-DNA;Elements;Escherichia coli;Evolution;Exclusion;Exhibits;Family;Future;Gene Pool;Genes;Genetic;Genome;Genomic Segment;Genomics;Health;Human;Immunity;Infection;Injections;insight;interest;Knowledge;Laboratories;Libraries;Link;Lysogeny;Lytic;Mediating;Methods;Microvirus;Modeling;Molecular;mutant;Mutation;novel;Nucleotides;Phenotype;Population;Population Dynamics;prevent;Process;Prophages;Single Stranded DNA Virus;Single-Stranded DNA;success;superinfection;System;Testing;Variant;Viral;Virus

PROJECT_TITLE: Mechanisms and dynamics of superinfection exclusion in microviral prophage populations


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Bioengineering;Emerging Infectious Diseases;Foodborne Illness;Genetics;Infectious Diseases;Rare Diseases;Wound Healing and Care

ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: Project Narrative Pathogenic Vibrio bacteria cause the acute disease vibriosis in humans, resulting in rapid symptom progression and high mortality if untreated. Due to globally increasing rates of vibriosis and multi-antibiotic resistant Vibrio strains, we aim to develop alternative therapeutic approaches to treat vibriosis disease. We will utilize an ex vivo skin wound infection model to study Vibrio vulnificus virulence factor production and treatment with novel antibacterial compounds.

PI_NAMEs: VAN KESSEL, JULIA C. (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: 3-Dimensional;Acute;Acute Disease;Anti-Bacterial Agents;Anti-Infective Agents;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Aquaculture;Artemia;Automobile Driving;Bacteria;Bacterial Infections;Binding;Biological Assay;Biological Models;Cell Culture Techniques;cell growth;Cell Survival;Cells;Cessation of life;Chemicals;Clinic;coastal water;Collaborations;combinatorial;Communication;Communities;Complex;contaminated seafood;Cytotoxin;Dermal;Dermis;Development;Diameter;Disease;Dose;drug development;Drug Targeting;Eating;Ecosystem;efficacy evaluation;Enzymes;Epidermis;Evolution;ex vivo imaging;experimental study;Farm;Fluorescent in Situ Hybridization;Future;Gastroenteritis;Gene Deletion;Gene Expression;Genes;Genetic;Genetic Transcription;Goals;Hemolysin;Hemolysis;Homologous Gene;Human;human disease;human mortality;imaging modality;Imaging Techniques;In Situ;in vivo;Individual;Infection;Infectious Skin Diseases;inhibitor;innovation;Iowa;Ligand Binding;Location;marine;Marketing;Microbial Biofilms;Microscopy;Modeling;Monitor;Morbidity - disease rate;mortality;Motility;Multi-Drug Resistance;Mus;mutant;Nature;Necrotizing fasciitis;novel;novel therapeutics;Oceans;open wound;Oysters;Pathogenesis;Pathogenicity;Pathway interactions;Pattern;Penaeidae;Peptide Hydrolases;Phenotype;Polysaccharides;Predisposition;prevent;Production;Productivity;programs;Proliferating;Proteins;Protocols documentation;Publishing;Pyrazoles;quorum sensing;Reaction;Research;resistant strain;response;Role;Seawater;Sepsis;Shrimp;Siderophores;Signal Transduction;Skin;skin microbiome;Skin Tissue;skin wound;Study models;Symptoms;Techniques;Temperature;Testing;Therapeutic;Three-Dimensional Imaging;tissue fixing;Tissues;Toxin;Universities;Vibrio;Vibrio Infections;Vibrio vulnificus;Virulence;Virulence Factors;virulence gene;Visualization;Wound Infection;Wound models;wound treatment

PROJECT_TITLE: Ex vivo skin wound infection model for Vibrio vulnificus pathogenesis

STUDY_SECTION: BV

STUDY_SECTION_NAME: Bacterial Virulence Study Section [BV]


NIH_SPENDING_CATS: Biotechnology;Eye Disease and Disorders of Vision;Infectious Diseases

ORG_CITY: CORAL GABLES

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE

PHR: PROJECT NARRATIVE Current gold standard to determine the pathogens causing infectious keratitis still includes time consuming culture of corneal samples, which leads to false negative results in many cases and delays in determining the correct treatment approach. These delays frequently cause significant complications and unfavorable clinical outcomes, including blindness. This proposal by a team of PI’s in the Bascom Palmer eye institute (BPEI) will validate a novel assay to identify ocular pathogens, allowing for rapid determination of pathogens. 1

PI_NAMEs: KURTENBACH, STEFAN  (contact)

PROGRAM_OFFICER_NAME: MCKIE, GEORGE ANN

PROJECT_TERMS: Acanthamoeba;Adenoviruses;Artificial Intelligence;assay development;Bacteria;Benign;Biological;Biological Assay;Blinded;Blindness;Candida;Candida albicans;Clinical;clinical implementation;Communicable Diseases;Consumption;Cornea;cost;Cytolysis;Data;design;Detection;Development;Disease;DNA;Double-Blind Method;Epidemiology;Eye;Faculty;Freezing;fungus;Fusarium;Genomic DNA;Genomics;Haemophilus influenzae;Herpesvirus 1;Herpesvirus Type 3;Heterogeneity;Hour;Image Analysis;improved;individualized medicine;Infection;Joints;Keratitis;Laboratories;Libraries;Liquid substance;Microbiology;next generation sequencing;novel;Ocular Pathology;ocular surface;Organism;Outcome;Parasites;pathogen;Pathogen detection;pathogen genomics;Patient Care;Patient-Focused Outcomes;Patients;Physician Executives;portability;programs;prospective;Prospective Studies;prospective test;Pseudomonas aeruginosa;rapid detection;rapid technique;repository;Research Personnel;Reverse Transcription;RNA;Route;Running;Sampling;Specificity;Staphylococcus aureus;Staphylococcus epidermidis;Streptococcus pneumoniae;Surface;Swab;System;Testing;Time;Tissues;treatment strategy;Unfavorable Clinical Outcome;validation studies;Virus;Visual impairment;Work

PROJECT_TITLE: Developing a high-throughput panel for rapid detection of pathogens causing infectious keratitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-P (81)]


NIH_SPENDING_CATS: Behavioral and Social Science;Cardiovascular;Clinical Research;Contraception/Reproduction;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pediatric;Pregnancy;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: MISCELLANEOUS

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: PROJECT NARRATIVE The proposed program is relevant to public health because women from minority racial/ethnic groups suffer disproportionately more from hypertensive disorders of pregnancy (HDP) compared to their non-minority peers. This study will develop a decision-model platform to facilitate comparisons of potential health benefits and costs of HDP prevention and treatment strategies across racial/ethnic groups in the United States.

PI_NAMEs: OGBUOJI, OSONDU  (contact)

PROGRAM_OFFICER_NAME: DAGHER, RADA K

PROJECT_TERMS: Address;adverse birth outcomes;adverse pregnancy outcome;Age;alternative treatment;Aspirin;Automobile Driving;Biological;Biological Models;Birth;Birth Records;Black Populations;Body mass index;Cardiovascular Diseases;Cardiovascular system;Caring;Child;Chronic;combat;Complex;cost;Costs and Benefits;Data;Data Files;Decision Modeling;Development;Discrimination;Disease;Disparity;disparity reduction;Dose;Eclampsia;economic cost;Economic Factors;ethnic disparity;Ethnic Origin;Ethnic Population;evidence base;experience;Family;Funding;Future;Goals;Gynecologist;Health Benefit;health care availability;Health Care Costs;health care quality;health determinants;health disparity;health outcome disparity;Health system;Healthcare Systems;Household;Hypertension;Incidence;Individual;Infant;Intervention;K-Series Research Career Programs;Link;Lived experience;Modeling;modifiable risk;mortality;Mothers;multidisciplinary;National Institute on Minority Health and Health Disparities;Natural History;Not Hispanic or Latino;Obesity;Outcome;Outcome Measure;Parents;Pathway interactions;peer;Policies;Policy Maker;Population;Population Distributions;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Outcome;pregnancy prevention;Prevention;Prevention strategy;Primary Prevention;programs;Public Health;Publishing;Race;racial disparity;racial minority population;racial minority women;racial population;Research;Research Personnel;response;Review Literature;Risk Factors;Scientist;Secondary Prevention;Service delivery model;severe maternal morbidity;Severities;Smoking;social;societal costs;Socioeconomic Status;support tools;Testing;tool;treatment guidelines;treatment strategy;United States;Work

PROJECT_TITLE: Investigating Racial/Ethnic Disparities in Hypertensive Disorders in Pregnancy in the US


NIH_SPENDING_CATS: Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Depression;Fibromyalgia;Mental Health;Neurosciences;Pain Research;Rehabilitation

ORG_CITY: CHARLESTOWN

ORG_NAME: SPAULDING REHABILITATION HOSPITAL

PHR: PROJECT NARRATIVE Pain catastrophizing—a negative cognitive and emotional process that involves helplessness, rumination, and magnification of pain complaints—is the most consistent psychosocial factor predicting deleterious outcomes in chronic musculoskeletal pain, including fibromyalgia. We will use real-time functional magnetic resonance imaging (fMRI) neurofeedback to illuminate the role of self-regulatory capacity in shaping the negative effects of pain catastrophizing, and the positive benefits of cognitive-behavioral therapy. In the long term, these results will enable clinicians to boost the efficacy of CBT and facilitate the development of multimodal treatment packages, while patients gain control over their cognitive and emotional responses to pain.

PI_NAMEs: EDWARDS, ROBERT R;LEE, JEUNGCHAN  (contact)

PROGRAM_OFFICER_NAME: WANG, YAN Z

PROJECT_TERMS: Affect;Behavior;Brain;brain circuitry;Brain region;Chronic;chronic musculoskeletal pain;chronic pain;chronic painful condition;cingulate cortex;clinical predictors;Cognition;Cognitive;cognitive benefits;Cognitive Therapy;Combined Modality Therapy;Control Groups;Coping Skills;Development;Education;efficacious treatment;Emotional;Emotions;Fatigue;Fibromyalgia;fibromyalgia patients;Functional Magnetic Resonance Imaging;Goals;group intervention;Guidelines;improved;Individual;Informal Social Control;Measures;Mediating;Mental Depression;Nature;negative affect;neural;neural circuit;neural correlate;neurobiological mechanism;neurofeedback;neuromechanism;Nonpharmacologic Therapy;Outcome;Outcome Measure;Pain;pain catastrophizing;Pain Disorder;Pain interference;Pain management;Pain Measurement;pain outcome;pain reduction;Pathway interactions;Patients;Performance;placebo controlled study;Play;Prediction of Response to Therapy;Predictive Factor;Prefrontal Cortex;Process;Prognosis;Psychosocial Factor;Publishing;Randomized;reduce symptoms;response;Role;rumination;Self Assessment;Self Management;Shapes;skills;skills training;Sleep disturbances;Symptoms;Techniques;Thinking;Time;Treatment Effectiveness;treatment optimization

PROJECT_TITLE: Self-regulation of real-time fMRI brain activity in chronic pain: A potential neurobiological mechanism of cognitive behavioral therapy

STUDY_SECTION: NPI

STUDY_SECTION_NAME: Neurobiology of Pain and Itch Study Section [NPI]


ADMINISTERING_IC: NS

ED_INST_TYPE: EARTH SCIENCES/RESOURCES

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Bioengineering;Neurosciences;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Spinal Cord Injury;Transplantation;Traumatic Head and Spine Injury

ORG_CITY: LARAMIE

ORG_NAME: UNIVERSITY OF WYOMING

ORG_STATE: WY

PHR: PROJECT NARRATIVE Spinal cord injuries are devastating physical injuries that cause paralysis, sensory dysfunction, autonomic nervous system dysfunction, as well as bladder, bowel dysfunction and pain. Cell therapies of these injuries that involved Schwann cells have shown promise in animal studies but have been poorly transferrable to humans. In this project, innovative optogenetic (light-controlled) genetic circuits will be built into Schwann cells to improve their therapeutic potential.

PI_NAMEs: BUSHMAN, JARED SHANE;GOMELSKY, MARK  (contact)

PROGRAM_OFFICER_NAME: BAMBRICK, LINDA LOUISE

PROJECT_TERMS: Acute;Address;Allogenic;Animal Model;Animals;Antigen-Presenting Cells;Area;Autologous;Autonomic nervous system;Bladder;bone;Cell Count;cell injury;cell motility;Cell Survival;Cell Therapy;Cell Transplantation;cell type;Cells;Cessation of life;Clinical Trials;Coculture Techniques;cytokine;design;Effectiveness;Engineering;Environment;Fatty acid glycerol esters;Functional disorder;functional improvement;functional outcomes;Gene Expression;gene therapy;Genes;Genetic;Goals;high risk;Homologous Transplantation;Human;Immune;Immune response;Immune Tolerance;Immunologics;immunoregulation;improved;in vivo evaluation;inducible gene expression;Inflammatory;Injections;Injury;injury recovery;innovation;Interleukin-10;Intestines;irradiation;Kinetics;Lentivirus;Lentivirus Vector;Light;light emission;light intensity;Lymphocyte;migration;Modeling;Monkeys;Mus;Muscle;Myelin;Natural regeneration;Nerve Regeneration;neural;neuron regeneration;Neurons;neuroprotection;neurotrophic factor;novel strategies;optogenetics;overexpression;Pain;Paralysed;Penetration;performance tests;Photoreceptors;Positioning Attribute;Preparation;promoter;Property;prototype;Rattus;Recovery;Recovery of Function;regeneration potential;regenerative;Regenerative capacity;regenerative cell;Regimen;repaired;Reporter;Research;Risk;Safety;Schwann Cells;Sensory;severe injury;Site;Skin;Spinal Cord;Spinal Cord Contusions;Spinal cord injury;Spinal cord injury patients;System;Technology;Testing;Therapeutic;Therapeutic Effect;Time;Tissues;transcription factor;Transplantation;transplantation therapy;Viral

PROJECT_TITLE: Near-infrared light controlled transplanted cells to treat spinal cord injury

STUDY_SECTION: BNVT

STUDY_SECTION_NAME: Bioengineering of Neuroscience, Vision and Low Vision Technologies Study Section[BNVT]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Assistive Technology;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Clinical Research;Clinical Trials and Supportive Activities;Disability Research;Physical Rehabilitation;Rehabilitation

ORG_CITY: BOSTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: NORTHEASTERN UNIVERSITY

PHR: Project Narrative This research seeks to revolutionize the process of lower-limb prosthesis prescription by developing a high-precision, haptic, robotic ankle-foot prosthetic that can mimic the behavior of any commercially available prosthesis. By tailoring the prosthesis to the specific gait biomechanics and mobility needs of each patient, it has the potential to dramatically reduce the incidence of secondary complications associated with amputation, such as pain, reduced mobility, and decreased quality of life. As such, this project directly contributes to public health by enhancing the well-being and extending the active lives of individuals living with limb loss, while also reducing the healthcare costs associated with long-term disability and complications.

PI_NAMEs: SHEPHERD, MAX  (contact)

PROGRAM_OFFICER_NAME: BITTMANN, MORIA FISHER

PROJECT_TERMS: Address;Algorithms;Amputation;Amputees;Ankle;ankle prosthesis;Automobile Driving;Behavior;Biomechanics;Characteristics;Clinical;Communities;cost;Decision Making;design;Devices;electric impedance;Ensure;experimental study;Feedback;foot;Future;Gait;Goals;haptics;Health Care Costs;Heel;high risk;human subject;improved;improved mobility;Incidence;Individual;innovation;Intuition;Just-Noticeable Differences;kinematics;Knee;Knee Osteoarthritis;Leg;lens;limb loss;Limb Prosthesis;Long term disability;Low Back Pain;Lower Extremity;Manufacturer;Marketing;mechanical behavior;mechanical properties;Mechanics;Mobility decline;Modeling;Motor;new technology;Oils;Optometrist;Pain;Patient Appointment;Patient Preferences;patient-level barriers;Patients;Pattern;Perception;Performance;Personal Satisfaction;Pilot Projects;Positioning Attribute;preference;Procedures;Process;Prosthesis;prosthesis fitting;prosthetic alignment;prosthetic foot;Public Health;Quality of life;rapid test;Recommendation;Research;Resolution;Risk Reduction;robotic device;Robotics;sensor;Series;System;Tablets;Techniques;Testing;Time;tool;Torque;Translations;Vision;Visual;Walking;wearable device;Work

PROJECT_TITLE: A new clinical device to enable informed prosthesis prescription decision-making.

STUDY_SECTION: MRS

STUDY_SECTION_NAME: Musculoskeletal Rehabilitation Sciences Study Section[MRS]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases;Rare Diseases;Vector-Borne Diseases

ORG_CITY: BRONX

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: ALBERT EINSTEIN COLLEGE OF MEDICINE

PHR: Narrative  Alphaviruses include established and emerging human pathogens that cause serious diseases and are potential biodefense threats, and for which there are no antiviral therapies. This project aims to define the role and mechanisms of newly identified host cell proteins in the alphavirus infection cycle. The results will provide fundamental information on alphavirus-host interactions and inform new antiviral strategies.

PI_NAMEs: MARTIN, CAROLINE K (contact)

PROGRAM_OFFICER_NAME: DUPUY, LESLEY CONRAD

PROJECT_TERMS: 14-3-3 Family;Active Sites;Adaptor Signaling Protein;Alpha Virus;Alphavirus Infections;Amino Acyl-tRNA Synthetases;Anti-viral Therapy;Arthritogenic;Aspartate;Aspartate-tRNA Ligase;beta Spectrin;Biochemical;biodefense;Biological;Biological Assay;Biotin;Biotinylation;Capsid;Capsid Proteins;Cell membrane;Cell surface;Cells;Chemicals;chikungunya infection;Chikungunya virus;comparative;Complex;crosslink;Crosslinker;Cytoplasm;Disease;emerging human pathogen;env Gene Products;Evaluation;Family member;Genetic Screening;Genome;Grant;Health;Higher Order Chromatin Structure;Human;Hydrophobicity;Infection;innovation;Integral Membrane Protein;Integration Host Factors;knock-down;Knock-out;Libraries;Licensing;Life Cycle Stages;Lipid Bilayers;magnetic beads;Masks;Mass Spectrum Analysis;Mediating;member;Membrane;Membrane Fusion;Modeling;Monomeric GTP-Binding Proteins;novel;novel strategies;Nucleocapsid;organizational structure;overexpression;particle;Pathway interactions;Peptides;Permeability;permissiveness;Phenotype;Play;Post-Translational Protein Processing;Primary Infection;Production;Protein Biosynthesis;protein crosslink;protein expression;Protein Family;protein function;Protein phosphatase;protein protein interaction;Proteins;Retrieval;RNA;RNA replication;RNA Viruses;Role;Ross river virus;Scaffolding Protein;Semliki forest virus;Site;Small Interfering RNA;Spectrin;Statistical Data Interpretation;Streptavidin;Structural Protein;Structure;System;Testing;uptake;Vaccines;Venezuelan;Viral;Viral Proteins;viral resistance;viral RNA;Virion;Virus;Virus Diseases;virus envelope;Virus Receptors;Virus-like particle;Western Equine Encephalitis Virus

PROJECT_TITLE: Mechanisms of novel host factors in alphavirus infection

STUDY_SECTION: MCV

STUDY_SECTION_NAME: Molecular and Cellular Biology of Virus Infection Study Section[MCV]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Biotechnology;Infectious Diseases;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Substance Misuse;Wound Healing and Care

ORG_CITY: SOUTH ORANGE

ORG_DEPT: PHARMACOLOGY

ORG_NAME: SETON HALL UNIVERSITY

ORG_STATE: NJ

PHR: Project Narrative: Binge drinking has detrimental effects on tissue repair and cold plasma (CP) has emerged as a promising medical tool for wound healing. This project will investigate CP’s potential wound healing benefits by characterizing CP's wound healing properties in F344 rats exposed to binge ethanol (ETOH) and studying CP’s effects on wound healing in human skin organoids treated with EtOH at binge concentration. The study outcomes shall shift the paradigms regarding the interplay between wound healing properties of CP and alcohol-induced impairment of wound healing, eventually leading to clinical application of CP in wound healing during alcohol intoxication.

PI_NAMEs: CHANG, SULIE L. (contact)

PROGRAM_OFFICER_NAME: PERRUCCIO, ELIZABETH M

PROJECT_TERMS: 3-Dimensional;Abbreviations;acute stress;Address;Afferent Neurons;Alcohol consumption;alcohol effect;alcohol exposure;alcohol misuse;Alcoholic Intoxication;Alcohols;angiogenesis;Atmosphere;Attention;Award;beta catenin;Beverages;binge drinking;Biocompatible Materials;Bioinformatics;bioinformatics network;Biological Response Modifier Therapy;Blood alcohol level measurement;cancer cell;cancer therapy;CCL2 gene;Chemicals;chemokine;Clinical;clinical application;clinical practice;Collagen;combat;Consumption;CXCL2 gene;cytokine;Dermal;differential expression;Dose;Endothelial Cells;Enzyme-Linked Immunosorbent Assay;Ethanol;Exhibits;Exposure to;Female;Fibroblasts;Gases;Gene Expression;Gene Expression Profiling;Genes;Glutathione;Glutathione Disulfide;Grant;Growth;Growth Factor;Hair follicle structure;healing;Hematoxylin and Eosin Staining Method;Hour;Human;human induced pluripotent stem cells;IACUC;Immunofluorescence Immunologic;Impaired wound healing;Impairment;improved;In Vitro;Inbred F344 Rats;Infection;Infection prevention;Inflammation;Inflammatory;Inflammatory Response;Injury;Innate Immune System;interest;Interleukin-1 beta;Interleukin-10;Interleukin-6;Investigation;ionization;keratinocyte;knowledge base;Laboratories;Local Anti-Infective Agents;Macrophage;male;Mediating;Medical;Medicine;Meta-Analysis;Methods;Modeling;Molecular;Natural regeneration;Neuroglia;neutrophil;Nitrogen;novel strategies;nuclear factor-erythroid 2;Organoids;Outcome Study;Oxidation-Reduction;Oxidoreductase;Oxygen;Oxygenases;pathogen;Pathway Analysis;Pathway interactions;Patients;Periodicals;Phase;Physiology;Plasma;Predisposition;Prevalence;Production;Proliferating;Property;Reactive Nitrogen Species;Reactive Oxygen Species;Recording of previous events;regenerative;regenerative healing;Research;response;Risk;Risk Factors;Role;self organization;Signal Pathway;Signal Transduction;simulation;Skin;Skin graft;Solid;Stains;stem cell organoids;Superoxide Dismutase;Surgical Wound Infection;System;Testing;Therapeutic;Thick;Time;tissue injury;tissue regeneration;tissue repair;Tissues;TNF gene;tool;United States;United States Food and Drug Administration;wound closure;wound healing;Wound Infection;Wound models;wound treatment

PROJECT_TITLE: Investigation of cold plasma for healing alcohol-induced tissue injury

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


ADMINISTERING_IC: MH

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Childhood Injury;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Pediatric;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health;Suicide;Suicide Prevention

ORG_CITY: Newark

ORG_DEPT: PSYCHIATRY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: Leveraging 20 years of data collected annually from ages 6-26 among a low-income, underserved sample of Black youth, the current study will map the course of suicide ideation and behaviors (SIB) during adolescence and emerging adulthood, and will unveil critical risk and protective individual- and environmental factors associated with SIB course. Findings from the current study may inform etiological models of SIB in this vulnerable population and yield actionable knowledge regarding developmentally-relevant intervention targets to curb SIB among Black youth across the life course.

PI_NAMEs: LINDSEY, MICHAEL A.;RABINOWITZ, JILL ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: MURPHY, ERIC ROUSSEAU

PROJECT_TERMS: Address;Adolescence;Adolescent;Adult;African American population;Age;Area;Baltimore;Black race;black subgroup;Cause of Death;Characteristics;Cities;Congresses;contextual factors;Data;Data Collection;Data Set;Development;Disparity;early adolescence;early childhood;Early Intervention;emerging adult;emerging adulthood;Environmental Risk Factor;Etiology;Event;Factor Analysis;Feeling suicidal;Frequencies;Goals;Heterogeneity;indexing;Individual;inner city;Interruption;Intervention;Knowledge;Life;Life Cycle Stages;life span;Longitudinal Studies;Low income;Maps;Measures;Mental Health;Minority;Modeling;modifiable risk;Neighborhoods;Pathway interactions;Population;Positioning Attribute;Prevention;preventive intervention;protective factors;Public Health;racial discrimination;Recommendation;Reporting;Research;response;Risk;Risk Behaviors;Risk Factors;Sampling;Schools;Science;Severities;social;social determinants;social skills;Social support;socioeconomic disadvantage;Stressful Event;structural determinants;substance use;substance using adolescents;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide model;Suicide prevention;Symptoms;Time;Vulnerable Populations;Work;young adult;Youth

PROJECT_TITLE: Social-Ecological and Individual Determinants of the Course of Suicidal Ideation & Attempt among African Americans from Early Adolescence toYoung Adulthood

STUDY_SECTION_NAME: Special Emphasis Panel[ZMH1 ERB-N (02)]


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: RICHMOND

ORG_NAME: VIRGINIA COMMONWEALTH UNIVERSITY

ORG_STATE: VA

PHR: Project Narrative This application proposes creating several strains of knockout and transgenic mice that will allow lineage-restricted deletion of the gene Stat5B or expression of a Stat5B mutant that can form protein dimers but no tetramers. Because Stat5B is critical for many cell signaling pathways, these mice will be a valuable tool for understanding how Stat5B functions in specific cell types.

PI_NAMEs: RYAN, JOHN J (contact)

PROGRAM_OFFICER_NAME: SUBRAMANIAN, HARIHARAN

PROJECT_TERMS: Allergic Disease;Allergic inflammation;Anaphylaxis;Animals;Autoimmunity;Binding;Biology;cell motility;Cell Physiology;cell type;Cells;Cellular biology;Chronic;clinically relevant;cytokine;Data;dimer;Disease;DNA;Endocrine system;Family member;Functional disorder;Future;Gene Deletion;Gene Expression;Genes;genomic locus;Hematopoietic;Histamine;Histamine Production;Hypersensitivity;IgE Receptors;Immune system;immunodeficiency;In Vitro;Infertility;Inflammation;Inflammatory;interest;Knock-out;Knockout Mice;Knowledge;Liver;LoxP-flanked allele;Malignant Neoplasms;mammary;mast cell;Mediating;Metabolic Diseases;migration;Modeling;Mouse Strains;Mus;mutant;Mutant Strains Mice;novel;Phenotype;Production;Protein Isoforms;Proteins;Proto-Oncogene Protein c-kit;receptor;Role;selective expression;Signal Pathway;Signal Transduction;Site;STAT protein;STAT5B gene;Testing;tool;transcription factor;Transgenes;Transgenic Mice;translational impact;translational potential;Work

PROJECT_TITLE: Creation and Characterization of Lineage-Restricted Stat5B KO Mice

STUDY_SECTION: III

STUDY_SECTION_NAME: Innate Immunity and Inflammation Study Section[III]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Networking and Information Technology R&D (NITRD);Neurosciences;Stroke;Telehealth

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: Project Narrative Endovascular technologies (less invasive, more effective, and less risky) with clot retriever thrombectomy devices, flow diverters, and embolization coils, etc. have been widely used to treat cerebrovascular disease which is the 2nd leading cause of mortality in the world. However, the typical endovascular sequences often result in prolonged operational procedures and X-ray exposures due mainly to difficulties in translating proximal catheter/guidewire movements into anticipated movements at its distal end. This project will develop an innovative ? Robot-guided endovascular guidewire system controlled by a static, compact, cost-effective, and remote acoustic probe (similar to ultrasound imaging probe) that allows for full robotic/telerobotic neurovascular interventions substantially reducing the total procedure time and thus minimizing the exposure to harmful X-ray radiation.

PI_NAMEs: CHO, SUNG KWON  (contact);CHUN, YOUNG JAE

PROJECT_TITLE: MicroRobot Guidewire for Telerobotic Maneuvering in Tortuous Neurovascular Interventions

STUDY_SECTION: BTSS

STUDY_SECTION_NAME: Bioengineering, Technology and Surgical Sciences Study Section[BTSS]


ORG_CITY: Los Angeles

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE An ideal engineered biomedical hydrogel should have elastic properties that match well with the native tissue that it is being integrated. Conventional mechanical testing methods have many limitations such as being destructive measurements. In this proposal, we will develop a new technique named two-dimensional acoustic force elastography microscopy (2D-AFEM) for characterizing elastic property of cell encapsulated scaffolds in various biomedical and tissue engineering applications.

PI_NAMEs: LIU, HSIAO-CHUAN  (contact)

PROGRAM_OFFICER_NAME: YEH, ALVIN TIEN-WEI

PROJECT_TERMS: Acoustics;Address;Affect;Behavior;Biochemical;Biochemical Markers;Biocompatible Materials;Biological;Biomedical Engineering;BMP2 gene;California;Cell Adhesion;cell behavior;Cell Density;Cell Differentiation process;cell motility;Cell Proliferation;Cells;Cicatrix;Clinic;Collagen;crosslink;data acquisition;density;design;Development;diabetic wound healing;Elasticity;elastography;Encapsulated;Engineering;Environment;Evaluation;Extracellular Matrix;Foreign Bodies;Functional impairment;Gelatin;Growth;Heterogeneity;Human body;hydrogel scaffold;Hydrogels;hydrophilicity;implantable device;improved;Infiltration;Lead;Link;Longitudinal Studies;Measurement;Measures;Mechanics;Methods;Microscope;Microscopy;migration;mineralization;Modality;Modulus;Molecular Weight;Names;Operative Surgical Procedures;Optical Coherence Tomography;Organ;Pattern;Peptides;Performance;Play;Polymers;Proliferating;Property;Resolution;response;Sampling;scaffold;Scanning;seal;sealant;simulation;Structure;Surface;Swelling;System;Techniques;Testing;Theoretical model;Thinness;Time;Tissue Engineering;Tissues;Transducers;trend;two-dimensional;Ultrasonic Transducer;ultrasound;Universities;Water;wearable device;wearable monitor;wound dressing

PROJECT_TITLE: Development of two-dimensional (2D) acoustic force elastography microscopy for the non-contact measurement of elastic property of cell encapsulated scaffolds

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-M (82)]


NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Kidney Disease;Patient Safety;Urologic Diseases

ORG_CITY: Nashville

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: Project Narrative Each year, over 100,000 patients require endoscopic (i.e. minimally invasive) surgery for kidney stone disease in the United States. Approximately 25% of these patients require repeat surgery for residual stone fragments, which can lead to obstruction, pain, kidney injury, and urinary tract infections, with more inexperienced surgeons having a higher risk of repeat surgeries. This proposal aims to create an eye gaze sharing system to improve surgical training and guidance so that trainees acquire skills faster and beneﬁt more from an expert mentor’s experience.

PI_NAMEs: KAVOUSSI, NICHOLAS L;WU, JIE YING  (contact)

PROJECT_TERMS: Ally;Augmented Reality;Behavior;Clinical;Communication;Complement;Computer software;Data;Development;Devices;Disease;Education;Endoscopes;Endoscopic Surgical Procedures;Environment;Excision;experience;experimental study;Eye;eye hand coordination;Feedback;flexibility;Future;gaze;Goals;Head;head mounted display;high risk;Image;improved;improved outcome;Incidence;indexing;Injury to Kidney;Intervention;Kidney;Kidney Calculi;kidney surgery;kidney visualization;Laparoscopic Surgical Procedures;Maps;Measures;Memory;Mentors;Methods;minimally invasive;Monitor;Motion;Movement;Multi-Institutional Clinical Trial;novel;Obstruction;Operating Rooms;Operative Surgical Procedures;Outcome;Pain;patient safety;Patient-Focused Outcomes;Patients;Pattern;Performance;Postoperative Period;Prevalence;Procedures;Psyche structure;Recurrence;recurrent infection;Repeat Surgery;Research;Residual state;robot assistance;Robotics;Running;sharing platform;skill acquisition;skills;Societies;standard of care;statistics;success;Surgeon;System;Technology;Time;tool;Training;United States;Ureteral obstruction;Ureteroscopy;Urinary tract infection;Validation;verbal;virtual surgery;visual tracking;Visualization;Work

PROJECT_TITLE: Development and Validation of Gaze-based Training for Endoscopic Kidney Stone Surgery

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Complementary and Integrative Health;Mental Health;Mental Illness;Neurosciences;Post-Traumatic Stress Disorder (PTSD)

ORG_CITY: SAN DIEGO

ORG_NAME: VETERANS MEDICAL RESEARCH FDN/SAN DIEGO

PHR: PROJECT NARRATIVE Maladaptive responses to interoceptive cues underlie several mental and physical health conditions. We propose a novel integrative treatment, Interoceptive Training Enhanced Mindfulness (ITEM), that combines interoceptive exposure with mindfulness to optimize change in anxiety sensitivity, i.e., discomfort with fear- related physiological sensations. The project will involve iterative refinement of ITEM, evaluation of its feasibility and acceptability and development of a multi-modal assessment battery for future efficacy studies.

PI_NAMEs: LANG, ARIEL J (contact)

PROGRAM_OFFICER_NAME: BAUMGARTNER, JENNIFER NICOLE

PROJECT_TERMS: acceptability and feasibility;Adherence;Anxiety;anxiety reduction;anxiety sensitivity;Arousal;Assessment tool;Atrial Fibrillation;Awareness;chronic pain;clinical effect;clinically relevant;Cognitive Therapy;coping;Cues;Development;Diagnostic;Diagnostic Factor;Disease;Eating Disorders;Ecological momentary assessment;efficacy study;Electroencephalography;Esthesia;Evaluation;Exercise;experience;Exposure to;Feedback;Fright;Future;Health Benefit;Hybrids;Integrative Therapy;Intervention;intervention refinement;learning extinction;Maintenance;Measurement;Measures;Mental Depression;Mental Health;Methodology;military veteran;Mind-Body Intervention;mindfulness;mindfulness intervention;Mindfulness Training;multimodality;neural;novel;Outcome;Panic Disorder;Participant;Patients;physical conditioning;Physiological;population health;Post-Concussion Syndrome;Post-Traumatic Stress Disorders;predicting response;Process;psychologic;Psychometrics;Psychopathology;Randomized;Randomized, Controlled Trials;Reaction;reduce symptoms;response;Severities;social;Stimulus;success;Symptoms;telehealth;Toxicant exposure;Training;Trauma;Uncontrolled Study;Veterans;yeast two hybrid system

PROJECT_TITLE: Interoceptive Training Enhanced Mindfulness (ITEM): Acceptability and Measurement

STUDY_SECTION_NAME: Special Emphasis Panel[ZAT1 BH (01)]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Orphan Drug;Rare Diseases

PHR: Public Health Relevance Statement The research outlined in this R21 award will elucidate the mechanism of how FOSL1 undergoes phase separation to establish super-enhances to promote key oncogene expression in head and neck cancer. The results and outcomes from this study may provide conclusive evidence to support the promising concept that targeting FOSL1 phase separation suppresses tumorigenesis of head and neck cancer.

PI_NAMEs: LI, JIONG  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Acceleration;Artificial Intelligence;Biological Process;cancer therapy;Cell Physiology;cell type;Cells;Chimeric Proteins;Classification;Complex;density;Development;Diagnostic;Disease;Disease Progression;Drug Design;effective therapy;enhanced green fluorescent protein;Enhancers;Exploratory/Developmental Grant for Diagnostic Cancer Imaging;expression vector;Family;Family member;Fluorescent in Situ Hybridization;FOSL1 gene;Foundations;Future;Genes;genetic regulatory protein;Genetic Transcription;Genomic Segment;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;high risk;Homeostasis;HPV negative;HPV-negative head and neck cancer;In Vitro;inhibitor;Investigation;Link;Liquid substance;Malignant - descriptor;Malignant Neoplasms;malignant phenotype;Mediating;Mediator;Membrane;Modeling;Molecular;mutant;novel strategies;novel therapeutics;Oncogenes;Outcome Study;patient derived xenograft model;Patients;Phase;Physical condensation;programs;Proteins;public health relevance;Recombinant Proteins;Reporting;Research;RNA;Solid;spatiotemporal;Structure;Survival Rate;Testing;Therapeutic;therapeutic target;transcription factor;Transcription Factor AP-1;Transcriptional Activation Domain;treatment strategy;tumorigenesis;United States;United States National Institutes of Health;Visualization

PROJECT_TITLE: Connecting liquid-liquid phase separation with super-enhancers and key oncogene transcription in HNSCC

STUDY_SECTION: CG

STUDY_SECTION_NAME: Cancer Genetics Study Section[CG]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: BLACKSBURG

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: VIRGINIA POLYTECHNIC INST AND ST UNIV

PHR: Project Narrative  Brucella spp. are bacteria that cause a debilitating, flu-like disease in humans, and these bacteria are classified as Select Agents due to their potential use as biological weapons. Currently, treatment options for human Brucella infection are limited and often do not clear the infection. The proposed research will define a novel small regulatory RNA pathway in Brucella that may be targeted for in future therapeutic development.

PI_NAMEs: CASWELL, CLAYTON C (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, SUMAN

PROJECT_TERMS: abortion;Adopted;Animal Model;Animals;Antibiotic Therapy;Antibiotics;attenuation;Bacteria;bacteria classification;Binding;Bioinformatics;Biological;Biological Process;Biology;bioweapon;Brucella;Brucella abortus;Brucellosis;cell envelope;Cells;Characteristics;Chronic;combat;coping;Critical Pathways;Data;design;Detergents;Development;Disease;Domestic Animals;Elements;Event;experimental study;exposed human population;Exposure to;flu;Future;Gene Expression;Genetic;Glean;Goals;host colonization;Human;Immune;Infection;Laboratories;Macrophage;Mediating;Mediator;Membrane;Messenger RNA;Methodology;Molecular Chaperones;Mus;new therapeutic target;novel;novel therapeutic intervention;novel therapeutics;novel vaccines;Nutrient;Oxidative Stress;Oxygen;pathogen;Pathogenesis;pathogenic bacteria;Pathway interactions;Phenotype;posttranscriptional;Procedures;Process;programs;Proteomics;Reactive Oxygen Species;Recurrent disease;Regulatory Pathway;Relapse;Research;Research Personnel;RNA;Role;Small RNA;Sodium Dodecyl Sulfate;Sterility;Stress;Structure;System;Testing;Therapeutic;therapeutic development;Transcript;transcriptomics;Treatment Protocols;vaccine strategy;Vaccines;Virulence;Wild Animals;Work

PROJECT_TITLE: Characterizing a novel Brucella small RNA critical for cell envelope integrity

STUDY_SECTION: PCMB

STUDY_SECTION_NAME: Prokaryotic Cell and Molecular Biology Study Section[PCMB]


NIH_SPENDING_CATS: Neurosciences

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: PROJECT NARRATIVE Multiple brain regions cooperate to perform their tasks, and abnormal communication between them leads to brain dysfunction and neurological diseases. The proposed research aims to understand the neuronal circuit crucial for the communication between the cerebellum and the cerebral cortex, which is involved in various brain functions. Therefore, this project is directly relevant to the part of NIH’s mission that pertains to reducing the burden of neurological diseases through basic research.

PI_NAMEs: NISHIYAMA, HIROSHI  (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Action Potentials;Acute;Affect;Anatomy;Applications Grants;Area;Axon;Basic Science;Behavior;Body part;Brain;brain dysfunction;Brain region;Cells;Cerebellar Nuclei;Cerebellum;Cerebral cortex;Cerebrum;Characteristics;Cognitive deficits;Communication;Data;Development;Emotional;Exhibits;Foundations;Frequencies;Future;Gene Expression Profile;Heterogeneity;improved;Individual;insight;Interneurons;Label;Mammals;Mediating;Memory;Mission;Modeling;Molecular;Morphology;Motor;Motor Cortex;Movement;Nervous System Disorder;neural circuit;neuronal circuitry;Neurons;novel;optogenetics;Parvalbumins;patch clamp;Pattern;Physiological;Population;presynaptic;Presynaptic Terminals;Probability;Process;Property;Quality of life;Research;Research Project Grants;Rodent;Role;segregation;Signal Transduction;Slice;Synapses;Synaptic Transmission;System;Thalamic Nuclei;Thalamic structure;Transgenic Mice;Troponin;United States National Institutes of Health;Variant

PROJECT_TITLE: The organization of cerebello-thalamo-cortical circuit in the motor system

STUDY_SECTION: NC

STUDY_SECTION_NAME: Neuronal Communications Study Section[NC]