NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Burden of Illness;Cardiovascular;Caregiving Research;Clinical Research;Dementia;Lewy Body Dementia;Mental Health;Neurodegenerative;Neurosciences;Palliative Care;Parkinson's Disease

ORG_CITY: AUSTIN

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF TEXAS AT AUSTIN

PHR: Project Narrative Lewy Body Dementia (LBD; the current term that encompasses Dementia with Lewy Bodies and Parkinson’s Disease with Dementia) is the second most common cause of dementia, accounting for 4 to 15% of dementia cases. Caregivers for LBD experience a distinct profile of demands that include: a) cognitive symptoms similar to Alzheimer’s Disease, b) motor symptoms of Parkinson’s Disease, and c) additional core symptoms of LBD that differ from other dementias in their presentation: fluctuations in cognition, hallucinations, delusions and REM behavioral sleep disturbances (including acting out dreams). The proposed study will enhance the well- being of spoual caregivers for older adults with LBD by gathering information about caregiving tasks, caregiver stress, and caregivers’ psychological and physical reactions to that stress throughout the day, allowing development of caregiver interventions and programs tailored to the unique needs of caregivers for older adults experiencing Lewy Body Dementia.

PI_NAMEs: FINGERMAN, KAREN L (contact)

PROGRAM_OFFICER_NAME: GERALD, MELISSA S

PROJECT_TERMS: Accounting;Acting Out;Address;Adult;Affect;Agitation;Alzheimer's Disease;associated symptom;Attention;Automobile Driving;Autopsy;Behavioral;biological adaptation to stress;Buffers;Cardiovascular Physiology;Cardiovascular system;care giving burden;care recipients;caregiver interventions;caregiver stress;Caregiver support;Caregiver well-being;Caregivers;caregiving;Caring;Cellular Phone;Charge;Cognition;Cognitive;Communities;Delusions;Dementia;dementia care;Dementia caregivers;Dementia with Lewy Bodies;design;Development;Dreams;Ecological momentary assessment;Emotional;experience;Family Caregiver;Family member;fitbit;Hallucinations;Heart Rate;heart rate variability;Hour;Impaired cognition;information gathering;innovation;Intervention;Interview;Lewy Body Dementia;Literature;Measures;Modeling;Moods;motor symptom;Nature;Neurobehavioral Manifestations;older adult;Outcome;Parkinson Disease;Parkinson's Dementia;Personal Satisfaction;Persons;physical conditioning;Physiological;programs;psychologic;psychosocial resources;Public Health;Reaction;Reporting;Research;Research Personnel;Research Support;resilience factor;Sampling;Self Efficacy;sensor;Services;Sleep;Sleep disturbances;Social support;Speech;Spouses;Stress;Stress and Coping;stress reactivity;Stress Tests;stressor;Surveys;Symptoms;theories;United States National Institutes of Health

PROJECT_TITLE: Daily Experiences and Well-being among  Caregivers for Older Adults Experiencing Lewy Body Dementia.

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 SCIL-K (02)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Clinical Research;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Osteoporosis;Physical Injury - Accidents and Adverse Effects;Prevention

ORG_CITY: Newton

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: BIOSENSICS, LLC

ORG_STATE: MA

PHR: PROJECT NARRATIVE  Approximately 1 in 3 women and 1 in 5 men over the age of 50 will suffer from a fragility fracture in their remaining lifetime. Fragility hip fracture is one of the most serious and debilitating outcomes of osteoporosis with a 20–40% mortality rate during the first year after the fracture. Therefore, we propose to develop a cloud-based platform for automatic, opportunistic screening of X-ray image studies that will stand by in the central imaging data server of a hospital, investigate each non-investigated femur X-ray study, and flag the studies of patients that are detected to be at risk for a fragility fracture of the femur.

PI_NAMEs: NAZARIAN, ARA ;VAZIRI, ASHKAN  (contact)

PROGRAM_OFFICER_NAME: TSAP, LEONID V

PROJECT_TERMS: Age;American Medical Association;Architecture;Artificial Intelligence;automated analysis;Biomechanics;Bone Density;bone fragility;bone geometry;Caring;Categories;Classification Scheme;Clinical;Clinics and Hospitals;cloud based;Cloud Service;Code;Collaborations;Computer software;Current Procedural Terminology;Current Procedural Terminology Codes;Data;Death Rate;density;Detection;Diagnostic;Disease;editorial;Endocrinology;Evaluation;Femoral Fractures;Femur;Fracture;fracture risk;fragility fracture;high risk;hip bone;Hip Fractures;Hospitals;Image;imaging study;Incidence;Individual;insight;Ionizing radiation;Life Expectancy;Marketing;Medical Imaging;medical schools;men;Metastatic Neoplasm to the Bone;Orthopedics;Osteoporosis;Outcome;Patients;Phase;Preventive measure;Procedures;Process;Radiation Dose Unit;radiological imaging;Radiology Specialty;Reporting;Resolution;Risk;Roentgen Rays;screening;Secure;Small Business Innovation Research Grant;Spinal Fractures;Structure;System;Technology;tumor;Vertebral Bone;Visualization;Woman;X-Ray Medical Imaging

PROJECT_TITLE: Automatic, Opportunistic Surveillance of Hip Bone Fragility in X-ray Images

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(11)-B]


ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Biotechnology;Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Neurosciences;Pediatric

ORG_NAME: VIVOVERSE, LLC

ORG_STATE: TX

PHR: Developmental disorders such as ADHD and autism are increasing among children, in part caused by exposure to chemicals in their environment with potentially neurotoxic effects. Current testing methods using small animals such as rats and mice are too slow, expensive, and increasingly limited by welfare regulations to test the effects of all chemicals in commercial use for how they affect nervous system development. We propose to use the small nematode C. elegans and develop a battery of tests based on their behavior and examinations of their developing neurons and synapses after exposing them to chemicals to predict the adverse effects of the chemical on the developing human brain.

PI_NAMEs: MONDAL, SUDIP  (contact)

PROGRAM_OFFICER_NAME: RAVICHANDRAN, LINGAMANAIDU V

PROJECT_TERMS: Adult;Adverse effects;Affect;Age;Anatomy;Animal Model;Animal Testing Alternatives;Animals;Attention deficit hyperactivity disorder;autism spectrum disorder;automated analysis;automated image analysis;Behavior;Behavior monitoring;Behavioral;behavioral phenotyping;Biological Assay;Biological Markers;biomarker identification;Brain;Bulla;Caenorhabditis elegans;Categories;Cell Culture Techniques;Cells;Chemical Exposure;Chemicals;Child;Code;Color;Complex;connectome;Consumption;cost;Data;Defect;Development;Developmental Disabilities;developmental disease;developmental toxicity;Devices;Diagnosis;dopaminergic neuron;Dose;Drosophila genus;Environment;experimental study;Exposure to;Foundations;Future;Gel;Gene Expression Profiling;Genes;genetic manipulation;Genetic Markers;hazard;Hazard Assessment;high resolution imaging;Human;Image;imaging platform;Immobilization;in silico;In Vitro;in vitro Model;in vivo;Individual;Industrialization;Intoxication;Kinetics;Label;Laboratories;Learning Disabilities;Libraries;Life Cycle Stages;Mammals;Manuals;Membrane;Methodology;Methods;Microfluidics;microphysiology system;model organism;Modeling;Motility;mRNA Expression;Mus;Nematoda;Nerve Degeneration;Nervous System;nervous system development;neural network;neurodevelopment;Neurodevelopmental Disorder;neuron development;neuron loss;Neurons;neurotoxic;neurotoxicity;neurotoxicology;Neurotoxins;Neurotransmitters;No-Observed-Adverse-Effect Level;novel;novel strategies;Organism;Pathway interactions;Pesticides;Pharmaceutical Preparations;Phase;Phenotype;Physiological;Proteins;Publications;Rattus;Regulation;Reporter;reproductive toxicity;Resolution;Risk Assessment;specific biomarkers;Stress;Swimming;Synapses;synaptogenesis;System;Testing;Three-Dimensional Image;Time;Toxic effect;toxicant;Toxicology;training data;Validation;welfare;Whole Organism;Work;Zebrafish

PROJECT_TITLE: High-Content in vivo DNT Test Batteries using Cell-Specific Characterization of the Neurodevelopment and Synaptogenesis in C. elegans as NAMs

STUDY_SECTION_NAME: Special Emphasis Panel[ZES1 LWJ-D (R4)]


ADMINISTERING_IC: HG

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

ORG_CITY: ATLANTA

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

ORG_STATE: GA

PHR: PROJECT NARRATIVE - OVERALL Building upon the success and leadership of key MSM faculty researchers, who are leaders in their respective fields of genomics, we will leverage MSM institutional strategic investments for translational genomics, industry partnerships and strategic collaborations with expert genomicists to create a world-class genomics research center. We propose an innovative shared resources model for the MSM Center for Genomic Diversity (CGD) to be seated within the new MSM’s Institute for Translational Genomic Medicine (ITGM). The administrative core will be led by Dr Melissa B Davis, the contact PI/PD for this U54 Proposal, who was recruited in 2022 as the founding Director of the ITGM. A group of Associate/Assistant Directors (ADs) with complementary expertise and diversity will co-manage the operations of three tiers representing 1- Administrative, 2-Data management and 3-Technology Development. Hinged on the premise of genetic diversity among groups of distinct geographical ancestry, and focused on the MSM mission of improving minority health, the CGD will provide a pace-setting novel data set and data repository while launching a new era of genomics research across the HBCU system.

PI_NAMEs: DAVIS, MELISSA B (contact)

PROGRAM_OFFICER_NAME: RIVERS, ROBERT C

PROJECT_TERMS: Admixture;Adopted;Affect;African;African American;Area;Automobile Driving;Biological;Chronic;cohort;Collaborations;Communities;community engagement;Community Health;Community Health Education;Conceptions;Consultations;Data;data infrastructure;data management;data repository;Data Set;Development;Education;education research;Educational Curriculum;Ensure;Environment;Epigenetic Process;epigenetic variation;Equity;Evaluation;experience;Faculty;Funding;Gene Expression Profiling;gene network;Generations;Genetic;Genetic Variation;Genome;genomic data;Genomic medicine;genomic profiles;genomic tools;Genomics;Geography;Goals;Health;health determinants;human reference genome;improve minority health;improved;Individual;industry partner;infant morbidity/mortality;Inflammation;Infrastructure;innovation;Institute of Medicine (U.S.);Institution;Investments;Knowledge;Lead;Leadership;Link;literacy;Maps;maternal morbidity;Maternal Mortality;Measures;member;Mentors;Minority Groups;Minority Health Research;Mission;Modeling;Morehouse School of Medicine;Neurologic;novel;operation;Outcome;pan-genome;Pathologic;Patient Outcomes Assessments;Pattern;portability;precision medicine;pregnant;programs;Race;racial disparity;recruit;reference genome;Research;Research Infrastructure;Research Personnel;Research Project Grants;Research Training;Resource Sharing;Resources;Schools;skills;social;Social Interaction;software development;Strategic Planning;Stress;success;synergism;System;Techniques;technology development;Testing;tool;Training;Training and Infrastructure;Training Programs;transcriptome;translational genomics;United States National Institutes of Health;Woman

PROJECT_TITLE: The Morehouse School of Medicine's Institute of Genomic Medicine Center for Genomic Diversity

STUDY_SECTION_NAME: Special Emphasis Panel[ZHG1 HGR-P (J1)]


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

PROJECT_TERMS: Administrative Coordination;Advisory Committees;Budgets;Cells;Clinical;Clinical Data;Clinical Research;cloud based;cluster computing;Collaborations;Communication;Communities;community advisory board;community engagement;community partners;Computational Biology;computer framework;computerized data processing;Creativeness;Data;Data Analyses;data communication;data harmonization;data integration;data management;data quality;data repository;data standards;design;Development;Education;effectiveness evaluation;Ensure;Environment;epigenomics;Ethics;Evaluation;Event;Faculty;Feedback;Funding Agency;Future;Generations;Genome;genome resource;genomic data;Genomic medicine;Genomics;Goals;Grant;Group Meetings;Growth;Health;Human Resources;implementation strategy;improved;Infrastructure;innovation;Institute of Medicine (U.S.);Institution;Investigation;Lead;Leadership;Libraries;Logistics;medical specialties;meetings;member;men who have sex with men;mid-career faculty;Minority-Serving Institution;Modeling;Morehouse School of Medicine;New York;novel;Occupational activity of managing finances;operation;organizational structure;Outcome;Output;Performance;Phase;Principal Investigator;Procedures;Productivity;programs;Progress Reports;prospective;Protocols documentation;Quality Control;Research;Research Activity;research data dissemination;Research Project Grants;Resource Sharing;Resources;Role;Sampling;scientific computing;sequencing platform;Services;Site;Standardization;Structure;System;Technology;technology development;Thinking;timeline;Training;Training Support;translational genomics;virtual;virtual machine;Visualization;Work;working group

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome;Pediatric

PHR: Narrative The Genomics Workforce Development Core aims to foster the development of undergraduate, predoctoral, and medical students and strengthen the training of postdoctoral trainees from underrepresented backgrounds in the field of genomics.

PI_NAMEs: LEAK-JOHNSON, TENNILLE S (contact)

PROJECT_TERMS: Address;Age;Artificial Intelligence;Awareness;Cardiovascular system;career;Caregivers;Child;Collaborations;College Preparation;Communities;community collaboration;community engagement;Community Health;Complement;cultural competence;Data Science;design;Development;doctoral student;Education;Educational Materials;Educational workshop;empowerment;Engineering;Evaluation;experience;Exposure to;Face;Faith-based organization;Family;Fostering;Funding Opportunities;Genetic;Genetic Enhancement;Genets;Genome;genome sciences;Genomic medicine;Genomics;Goals;graduate school;Health;health equity;Individual;innovation;Institute of Medicine (U.S.);Intelligence;interest;Intervention;Investments;K-12 student;Knowledge;Learning;Machine Learning;matriculation;medical schools;Medical Students;Medicine;Mentors;Methods;minority health;minority health disparity;Mission;Morehouse School of Medicine;National Human Genome Research Institute;novel;Outcome;outreach;Parents;Participant;Pathway interactions;pedagogical content;Philosophy;Physiology;Play;post-doctoral training;Postdoctoral Fellow;pre-doctoral;Preventive Medicine;Printing;Process;professional students;Program Effectiveness;programs;psychosocial;Readiness;recruit;Reduce health disparities;Research;Research Institute;Research Personnel;Research Project Grants;retention rate;Role;Scholars Program;School-Age Population;Science;scientific literacy;Scientist;Self Efficacy;Series;skills;Societies;STEM career;STEM field;Students;success;Support System;supportive environment;Systems Biology;theories;Training;Training and Education;training opportunity;Training Programs;translational genomics;undergraduate student;Underrepresented Populations;Underrepresented Students;United States National Academy of Sciences;United States National Institutes of Health;Universities;Virginia;Work;Workforce Development

PROJECT_TITLE: Workforce Development Core


NIH_SPENDING_CATS: Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Racial and Ethnic Minority Health Research;Rural Health;Social Determinants of Health

PHR: SPECIFIC AIMS: COMMUNITY ENGAGEMENT CORE The premise of the Community Engagement Core (CEC) is to advance the science of community engagement toward increasing African American (AA) and Hispanic communities’ participation in genomic research. Specifically, the CEC will implement a ‘community-centered’ multi-level and multi-domain participant-centric strategy to engage AA and Hispanic communities a) in the development of culturally appropriate interventions for genomic education; b) to promote their recruitment and retention in genomics research; and c) facilitate the translations and dissemination of study results. Advances in genomics have increased our understanding of the unique interplay between genetics, environment, behavior, and disease, which has led to the advancement of clinical-trial matching and precision health (medicine and prevention). However, these scientific advances are hampered by the inadequate representation of AA and Hispanic populations in genomic research studies; thus, it is paramount to identify effective engagement strategies to increase genomic knowledge and research participation among AA and Hispanic populations. The inclusion of these populations will help us understand the genomic contributions to certain diseases, increase representation of these groups in genomic research, thereby reducing health disparities and advancing health equity. We will train an existing cadre of lay community navigators as genomic navigators (GNs) to deliver relevant education and provide navigation services, to two populations historically underrepresented in genomic research. We seek to standardize the genomic education provided to AA and Hispanic participants by equipping each GN with evidence-based educational resources on genomics and research participation developed by the National Human Genome Institute (NHGRI). Based on previous work, we will culturally adapt the educational materials to multiple media content (audio and video) delivered via mobile tablet technology. It is expected the GNs will provide education and logistical support to AAs and Hispanics interested in participating in genomic research in rural and urban areas. Of note, the GNs will also address AA and Hispanic beliefs, values, attitudes, and preferences related to participation in research. The CEC will deploy evidence-based strategies and tactics for engaging all elements of our defined community. Historically, we have had success in enrolling and retaining AA and Hispanic members of our community by ensuring that they can trust our processes to protect their privacy and return value for their participation. Value in this instance goes beyond a transactional return of value to a more sustained return of value based on a deep understanding of community needs. The engagement framework incorporates the right people (roles), processes and platforms to ensure reproducible results. The Specific Aims guiding the Core activities are: Aim 1: Enhance sustainable partnerships with statewide community- and faith-based organizations through a Community Advisory Board to facilitate a series of structured educational sessions (townhalls) to address bioethics concerns and issues of trust relative to AA and Hispanics participation in genomic research. Aim 2: Implement multi-level engagement strategies, Genomic Navigators, to promote genomics research education and awareness, recruitment, and retention of study participants, and address social determinants of health. Aim 3: Evaluation of Core activities and dissemination of information to diverse stakeholders including Community members, Partner organizations, and relevant Service organizations or Policymakers, as well as the scientific community. Significance. The activities outlined in this proposal are congruent with the strategies in the Diversity Centers for Genome Research RFA listed for the Community Engagement Core: Applicants should describe strategies for recruiting and maintaining long-term relationships with communities to enhance genomic knowledge, integration with Center research projects, promotion of participation in genomics research and recruitment and retention of study participants and dissemination of information and data generated by the Center. Despite NIH mandates for adequate representation of all populations in research, AA and Hispanic populations remain largely under-represented, particularly in genomic research and clinical trials. Having a community advisory board (CAB) guided multi-level approach will lead to increased awareness, opportunity, and participation in genomic research among a diverse population of AAs and Hispanics.

PI_NAMEs: RIVERS, BRIAN M. (contact)

PROJECT_TERMS: Address;African American;African American population;Attitude;Awareness;Behavior;Belief;Bioethics;Calendar;Clinical Trials;Collaborations;Communities;community advisory board;community engagement;Community Health Education;Community Participation;community-centered;Conceptions;culturally appropriate intervention;Data;Development;Disease;Education;education research;education resources;Educational Materials;Elements;Enrollment;Ensure;Environment;Evaluation;Event;evidence base;Faith-based organization;Genetic;Genome;Genomic medicine;Genomics;health equity;Hispanic;hispanic community;Hispanic Populations;Human Genome;Information Dissemination;Institute of Medicine (U.S.);interest;Knowledge;Latinx;Latinx population;Medicine;member;Morehouse School of Medicine;Participant;Persons;Policy Maker;Population;Population Heterogeneity;Precision Health;preference;Prevention;Privacy;Process;recruit;Reduce health disparities;Reproducibility of Results;Research;Research Project Grants;research study;Role;rural area;Science;Scientific Advances and Accomplishments;Series;service organization;Services;social health determinants;Standardization;Structure;success;Tablets;Technology;Training;Transact;translational study;Translations;Trust;United States National Institutes of Health;urban area;Work;Workforce Development

PROJECT_TITLE: Community Engagement Core


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Maternal Health;Mental Health;Pediatric;Racial and Ethnic Minority Health Research;Social Determinants of Health;Women's Health Research

PHR: NARRATIVE Preconception risk factors associated with maternal and infant mortality are more common among African American women of reproductive age and these disparities are rooted in structural racism and discrimination (SRD), which is a salient mechanism perpetuating racial gaps in health. This proposed study seeks to investigate the etiologic pathways during the pre-pregnancy period that are influenced by SRD-related trauma and to determine the longitudinal impact on the epigenome in the mother-infant dyad. Results from these studies may inform future interventions to address health disparities among at-risk mother-infant pairs and can promote their overall health and well-being.

PI_NAMEs: JOHNSON, ERICA L (contact)

PROJECT_TERMS: Accounting;Address;adverse outcome;adverse pregnancy outcome;Affect;African American;African American Women;African ancestry;Age;Biological;Biological Markers;Biological Models;Cardiovascular system;Cells;Child;child bearing;Chronic;Chronic Disease;cohort;Conceptions;cytokine;Death Rate;Diabetes Mellitus;Discrimination;Disparity;Education;Endocrine;Enrollment;Environment;Epigenetic Process;epigenome;epigenomics;Etiology;Female of child bearing age;Fetus;Future;Gene Expression;Generations;genetic signature;Genetic Transcription;genome sequencing;genome-wide;Genomic medicine;Genomics;Germ Lines;Health;health disparity;Hypertension;Immune;immune activation;Immune System Diseases;Immunity;Immunologics;Incidence;Individual;Infant;Infant Health;Infant Mortality;Inflammation;Inflammation Mediators;Inflammatory;Inherited;Institute of Medicine (U.S.);Intervention;life span;Longitudinal cohort;marginalized population;Maternal Health;Maternal Mortality;Maternal-Fetal Exchange;Metabolic dysfunction;Methylation;Modification;Morbidity - disease rate;Morehouse School of Medicine;mortality;Mothers;multiple omics;neonate;novel;Obesity;offspring;Outcome;outcome disparities;Pathway interactions;Pattern;perceived stress;Personal Satisfaction;Physiological;Placenta;Population;potential biomarker;Pregnancy;Pregnancy Outcome;Pregnant Women;Premature Birth;prepregnancy;Race;racial disparity;Regulation;reproductive;response;Risk;Risk Factors;Signal Transduction;Socioeconomic Status;Standardization;Stress;stressor;Structural Racism;Surveys;systemic inflammatory response;Tissues;Training;transcriptome sequencing;transmission process;Trauma;whole genome;Woman

PROJECT_TITLE: A model system to study the inheritability of structural racism and discrimination through epigenomics


NIH_SPENDING_CATS: Biotechnology;Building Research Capacity at Institutions with Limited NIH Funding;Genetics;Human Genome

PHR: NARRATIVE: This project will assess the improvement in RNA mapping accuracy when we move for using a common human reference genome to individual reference genomes. We will determine the tradeoff and benefits in terms of computational and data burden of personalized genomics.

PI_NAMEs: MELLER, ROBERT  (contact)

PROJECT_TERMS: Address;African;African American;African ancestry;American;Awareness;Benchmarking;Categories;cohort;Data;Data Set;Disease;DNA sequencing;empowerment;European;European ancestry;Faculty;Gene Expression;gene function;Genes;Genetic;Genetic Identity;genetic information;Genetic Transcription;Genome;Genomic medicine;Genomics;Goals;Graph;Haplotypes;Hispanic;Human;Human Genome;human pangenome;human reference genome;improved;Individual;individual response;Institute of Medicine (U.S.);Maps;Measures;men who have sex with men;Modeling;Morehouse School of Medicine;Outcome;pan-genome;Participant;Pattern;personalized genomics;personalized medicine;Persons;Population;population based;Population Genetics;Population Heterogeneity;Postdoctoral Fellow;Protein Isoforms;Publishing;Race;reference genome;Reporting;Research Project Grants;RNA;RNA analysis;RNA Splicing;Sampling;Series;statistics;Stroke;Students;Technology;technology development;telomere;Testing;Tissue-Specific Gene Expression;Training;training opportunity;Transcript;transcriptome;transcriptome sequencing;transcriptomics;United States National Institutes of Health;Variant

PROJECT_TITLE: Genomic Technology Development for Diverse Populations


FUNDING_MECHANISM: OTHER RESEARCH-RELATED

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Basic Behavioral and Social Science;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Genetics;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: MAYO CLINIC ROCHESTER

ORG_STATE: MN

PHR: PROJECT NARRATIVE Several antemortem biomarker and postmortem AD studies have shown a discrepancy between AD pathology extent, and cognition, forming the basis of cognitive resilience. A potentially protective microglial subpopulation, amyloid-responsive microglia (ARM), may play a role in cognitive resilience. This work focuses on understanding a specific microglial response and its antemortem predictors in the setting of AD neuropathology, cognition, and genetic risk.

PI_NAMEs: NGUYEN, AIVI THANH (contact)

PROGRAM_OFFICER_NAME: WAGSTER, MOLLY V

PROJECT_TERMS: abeta deposition;Address;age group;aged;Aging;aging related;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;Anatomy;Autopsy;awake;Award;Biological Markers;career development;Central Nervous System Diseases;Cessation of life;Clinic;Clinical Data;clinical training;Cognition;Cognitive;Cognitive aging;Complex;coping;Data;demographics;Deposition;Development;Development Plans;Disease Progression;Funding;Genetic;Genetic Risk;Genetic Transcription;glial activation;Glial Fibrillary Acidic Protein;Heterogeneity;Histologic;Human;human disease;human RNA sequencing;Image;in vivo;in vivo two-photon imaging;Individual;Infrastructure;Laboratory Research;Ligand Binding;Liquid substance;LysoTracker;Magnetic Resonance Imaging;magnetic resonance imaging biomarker;meetings;Membrane;Mentorship;Microglia;mouse model;Mus;Neurofibrillary Tangles;neuroimaging;neuroimaging marker;Neuroimmune;neuroinflammation;neuron loss;Neurons;neuropathology;neuroprotection;neuropsychiatry;Neuropsychology;normal aging;Participant;Pathologic;Pathology;Pennsylvania;Phagocytosis;Phenotype;Physicians;Plasma;Play;Population;population based;Positron-Emission Tomography;post-doctoral training;predictive marker;Prefrontal Cortex;professor;programs;receptor;Reporter;Research;resilience;resilience in aging;response;risk variant;Role;Scientist;Senile Plaques;serial imaging;single nucleus RNA-sequencing;skills;spatiotemporal;Subgroup;tau aggregation;tau Proteins;tau-1;Tauopathies;Testing;Time;Tissues;Transgenic Mice;Translational Research;TREM2 gene;two-photon;United States National Institutes of Health;Universities;University Hospitals;Visualization;Work

PROJECT_TITLE: Role of Microglial Heterogeneity on Cognitive Resilience in Aging and Alzheimer’s Disease

STUDY_SECTION: AGCD

STUDY_SECTION_NAME: Career Development for Clinicians/Health Professionals Study Section [AGCD-3]


FUNDING_MECHANISM: NON-SBIR/STTR RPGS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Complementary and Integrative Health;Dementia;Dietary Supplements;Health Disparities and Racial or Ethnic Minority Health Research;Microbiome;Neurodegenerative;Neurosciences;Nutrition;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The gut microbial community, in interaction with host dietary intakes, may play a significant role in the development of Alzheimer's dementia. Our proposed research aims to examine the contribution of gut microbes to the individual differences in the effects of the Mediterranean diet on age-related cognitive decline and the prevention of Alzheimer's dementia. By leveraging three well-conducted randomized controlled trials and a prospective cohort study, this project will establish fundamental insights into novel biological pathways, maximize the benefits of the Mediterranean diet, and ultimately develop more efficient and personalized dietary approaches to prevent Alzheimer's dementia effectively.

PI_NAMEs: CORELLA, DOLORES ;RUIZ-CANELA, MIGUEL ;SALAS SALVADO, JORDI ;TINAHONES	MADUEÑO, FRANCISCO  JOSÉ;WANG, DONG  (contact)

PROGRAM_OFFICER_NAME: ARUNKUMAR, NANDINI

PROJECT_TERMS: Acids;Age-associated memory impairment;aging brain;Alzheimer disease prevention;Alzheimer's Disease;Alzheimer's disease related dementia;Amines;Amyloid;Amyloid beta-Protein;Animal Model;authority;Bacteria;Bifidobacterium;Bile Acids;Biological;Biological Assay;Biological Markers;Blood;blood-brain barrier permeabilization;Brain;brain magnetic resonance imaging;Brain-Derived Neurotrophic Factor;Branched-Chain Amino Acids;Butyrates;Cognition;Cognitive;cognitive change;cognitive function;cognitive testing;Cohort Studies;Communication;comparison control;cost efficient;Data;Deoxycholic Acid;Deposition;design;Development;Diet;dietary approach;dietary control;Dietary intake;Dietary Intervention;efficacy evaluation;endophenotype;Enzymes;fecal microbiome;Feces;Flavonoids;follow-up;gamma-Aminobutyric Acid;Genetic Transcription;Glial Fibrillary Acidic Protein;gut microbes;gut microbiome;gut microbiota;gut-brain axis;Health;Hispanic Populations;Human Microbiome;imaging biomarker;Impaired cognition;improved;Individual;Individual Differences;individual response;Inflammation;insight;Kynurenine;Lactobacillus;Light;Link;Magnetic Resonance Imaging;Measurement;Measures;Mediterranean Diet;Metabolic;Metabolism;metabolomics;Metagenomics;metatranscriptomics;microbial;microbial composition;Microbial Taxonomy;microbiome;microbiome research;Mind;Molecular;multiple omics;Nerve Degeneration;neurofilament;neuroinflammation;neuropathology;Neurotransmitters;novel;Observational Study;Olive oil preparation;Oxides;Pathology;Pathway interactions;Peptides;personalized approach;Persons;Plasma;Play;Population;post intervention;precision medicine;precision nutrition;prevent;Prevention;Primary Prevention;Process;Production;prospective;Prospective cohort;Prospective, cohort study;Randomized, Controlled Trials;Recommendation;Reducing diet;Reporting;Reproducibility;Research;Resolution;Risk;Role;Sample Size;Sampling;Serotonin;Shotguns;stool sample;Study of Latinos;System;tau Proteins;Technology;Testing;Time;Validation;whole genome

PROJECT_TITLE: The Microbiome-Gut-Brain Axis and Personalized Mediterranean Diet Interventions for Alzheimer's Dementia Prevention

STUDY_SECTION: KEDD

STUDY_SECTION_NAME: Kidney Endocrine and Digestive Disorders Study Section[KEDD]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: RICHLAND

ORG_NAME: BATTELLE PACIFIC NORTHWEST LABORATORIES

ORG_STATE: WA

PHR: PROJECT NARRATIVE  Brain lipoproteins are lipid-protein complexes produced in the central nervous system that are important for maintaining brain health. The primary protein component on these particles is apolipoprotein (APO)E which has three different forms in people: E2, E3, and E4 and people who have E4 are at an elevated risk for development of Alzheimer’s disease. This work is aimed at understanding how E4 impacts the ability of brain lipoproteins to protect against the development of Alzheimer’s disease.

PI_NAMEs: MELCHIOR, JOHN  (contact)

PROGRAM_OFFICER_NAME: MCGAVERN, LINDA

PROJECT_TERMS: Adopted;Affect;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Alzheimer's disease risk;American;Amyloid beta-Protein;analog;Apolipoprotein E;apolipoprotein E-4;Arginine;Bathing;Binding;Biological Assay;Blood Vessels;Brain;Brain Diseases;brain health;Brain Mapping;Caucasians;Cells;Central Nervous System;Cerebrospinal Fluid;Clinical;Cognition;Cognitive;comparative;Complex;computerized tools;crosslink;Cryoelectron Microscopy;Cysteine;Data;Development;Docking;Epitopes;Etiology;Excision;Exhibits;Genetic Polymorphism;Genotype;Goals;Health;High Density Lipoproteins;Human;human old age (65+);Immune response;immunoregulation;Impaired cognition;Impairment;Incidence;Individual;Inflammation;Investigation;lifetime risk;Light;Lipid Binding;lipid metabolism;lipid transport;lipidomics;Lipids;Lipoproteins;Macrophage;Maps;Mass Spectrum Analysis;Measures;Memory;Memory Loss;Metabolism;mild cognitive impairment;Modeling;Molecular;Molecular Conformation;Molecular Profiling;Mutation;neural;Neurofibrillary Tangles;Neuronal Dysfunction;Neurons;novel;Outcome Study;Oxidative Stress;particle;Pathway interactions;Pattern;Peptides;Persons;Phenotype;Plasma;Plasma Proteins;Play;Population;prevent;protective pathway;protein complex;Protein Isoforms;Proteins;Proteolysis;Proteomics;reconstitution;Resolution;Risk;Role;scaffold;Senile Plaques;Site;Structural defect;Structure;Surface;targeted treatment;Technology;Therapeutic;Work

PROJECT_TITLE: The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: UNIVERSITY-WIDE

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Caregiving Research;Chronic Pain;Clinical Research;Dementia;Health Services;Neurodegenerative;Pain Research;Palliative Care

ORG_CITY: PORTLAND

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE Persons living with Alzheimer’s disease and related dementias are at high risk for non- beneficial, burdensome, and costly care at the end-of-life. This proposal investigates the role of hospice and/or palliative care (i.e., concurrent care) to improve the quality of end-of-life care by leading to fewer treatments before death likely to cause distress, discomfort, pain, and time away from home and loved ones. This work has the potential to improve the quality of end-of-life care and substantially impact future clinical and policy interventions among those with Alzheimer’s disease and related dementias.

PI_NAMEs: SULLIVAN, DONALD R (contact)

PROGRAM_OFFICER_NAME: KELLER, CHANDRA

PROJECT_TERMS: Address;Admission activity;Advanced Malignant Neoplasm;Alzheimer's disease patient;Alzheimer's disease related dementia;American;Atlases;beneficiary;Cancer Patient;care costs;care delivery;care outcomes;Caring;Caucasians;Cessation of life;Characteristics;chemotherapy;Clinical;community living;contextual factors;cost;cost comparison;Data;Decision Making;dementia care;design;Development;Disease;Distress;Dyspnea;end of life;end of life care;experience;Family;Family member;Future;Goals;Health Care Costs;Health care facility;Health Policy;Healthcare;Healthcare Systems;high risk;Home;Hospice Care;hospice environment;Hospice Programs;hospice utilization;Hospitalization;improved;improved outcome;innovation;Integrated Health Care Systems;Intervention;Interview;Knowledge;Life;Long-Term Care;loved ones;Malignant neoplasm of lung;Malignant Neoplasms;Marketing;Mechanical ventilation;Medical;medical specialties;Medicare;Methods;Mission;Modeling;National Institute on Aging;Natural experiment;Nursing Homes;Outcome;Pain;Palliative Care;Participant;Patient Care;Patient Preferences;Patients;Pattern;Penetration;Perception;Persons;Policies;Population;Positioning Attribute;Procedures;Process;Pulmonary Heart Disease;Qualifying;Qualitative Methods;Quality of Care;Quality of life;Records;Recurrence;Research;Research Design;Research Personnel;Research Support;Resources;Role;Sampling;socioeconomics;Structure;Surveys;Symptom Burden;symptom management;Symptoms;Time;Time trend;treatment as usual;United States Department of Veterans Affairs;Veterans Health Administration;Work

PROJECT_TITLE: Understanding and Improving Palliative Care Delivery among Persons with Alzheimer's Disease and Related Dementias (ADRD): A Mixed-Methods Study

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Pediatric;Substance Misuse;Underage Drinking

ORG_CITY: FAYETTEVILLE

ORG_NAME: UNIVERSITY OF ARKANSAS AT FAYETTEVILLE

ORG_STATE: AR

PHR: PROJECT NARRATIVE College student alcohol interventions often encourage students to employ Protective Behavioral Strategies when drinking to reduce alcohol-related harms, despite little evidence related to which specific strategies are useful and effective across contexts. The proposed mixed-method study aims to identify which Protective Behavioral Strategies for alcohol are most likely to be useful and effective across risky drinking contexts and why female and male students might or might not use these strategies in these contexts. The results will help inform improvements in existing alcohol harm reduction interventions.

PI_NAMEs: HAM, LINDSAY S.;ZAMBOANGA, BYRON L. (contact)

PROGRAM_OFFICER_NAME: KERRIDGE, BRADLEY TOWNSEND

PROJECT_TERMS: Adult;aged;alcohol consequences;Alcohol consumption;alcohol intervention;alcohol misuse;alcohol related consequences;alcohol risk;Alcohols;Behavior;Behavioral;Caring;Cognitive;Collaborations;college;college drinker;contextual factors;Data;Data Analyses;drinking;drinking behavior;Educational process of instructing;Effectiveness;eligible participant;evidence base;experimental study;Female;follow-up;Goals;Harm Reduction;Heavy Drinking;high risk drinking;improved;Individual;Intervention;Interview;Knowledge;Laboratories;Link;Literature;male;Methods;National Institute on Alcohol Abuse and Alcoholism;Outcome;Participant;Persons;Play;Positioning Attribute;Public Health;Qualitative Methods;recruit;Reporting;Research;Research Design;Respondent;response;Sampling;sex;Site;social cognitive theory;Structure;Students;success;Surveys;Testing;therapy development;tool;trend;university student;Visit;willingness;Work;young adult

PROJECT_TITLE: Protective Behavioral Strategies in Risky Drinking Contexts: A Mixed Method Study

STUDY_SECTION: ARM

STUDY_SECTION_NAME: Addiction Risks and Mechanisms Study Section[ARM]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Clinical Research;Hematology;Immunization;Immunotherapy;Lymphatic Research;Lymphoma;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_CITY: CHICAGO

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: PROJECT NARRATIVE Despite the success of immunotherapies and cellular therapies, most aggressive lymphomas will relapse with no consensus on the next best treatment strategy. We found recently that photothermal therapy with a toll-like receptor 9 agonists coated branched gold nanoparticle in a murine lymphoma model had (1) improved local and systemic anti-lymphoma T cell responses, (2) increased mature dendritic cells populations in lymph nodes, and (3) increased memory T cells populations in the spleen and untreated tumors. In this proposal, we will first further characterize the immune response of our photothermal therapy platform in various B cell lymphoma models, then combine our platform with T cell engaging immunotherapies such as checkpoint inhibitors and bispecific antibodies, and lastly examine a subcutaneous lymphoma lysate/nanoparticle mixture photothermal therapy platform for patients without easily accessible diseased lymph nodes.

PI_NAMEs: LIN, ADAM YUH (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Ablation;absorption;Agonist;anti-PD-1;anti-PD1 therapy;Antibody Therapy;Autologous Stem Cell Transplantation;B-Cell Lymphomas;Bispecific Antibodies;cancer therapy;CAR T cell therapy;CCL2 gene;CD3 Antigens;CD8B1 gene;Cell Therapy;Cells;Clinical;Clinical Trials;Combined Modality Therapy;Consensus;cytokine;Dendritic Cells;Dependence;design;Development;Devices;Disease;Disease remission;efficacy evaluation;Energy Transfer;External Beam Radiation Therapy;Follicular Lymphoma;Goals;Granulocyte-Macrophage Colony-Stimulating Factor;Growth;Hematologic Neoplasms;Immune;Immune checkpoint inhibitor;Immune Evasion;Immune response;immune stimulant;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;improved outcome;In complete remission;Indolent;Inflammatory;Inflammatory Response;innovation;Interleukin-1 beta;Interleukin-6;Knowledge;Large-Cell Lymphomas;Lasers;Light;Link;Location;Low-Level Laser Therapy;lymph nodes;Lymphoma;Lymphoma cell;Malignant Neoplasms;Mediating;Mentors;Methods;Modeling;mouse model;MS4A1 gene;Mus;Myeloid-derived suppressor cells;nano;nanoGold;nanoparticle;Nanotechnology;Neoplasm Metastasis;novel therapeutics;optical fiber;Pathway interactions;Patients;photothermal therapy;Physicians;Population;Radiation therapy;Refractory;Relapse;Research;response;Scientist;skills;Solid;Specificity;Spleen;subcutaneous;Subcutaneous Injections;success;synergism;System;T cell response;T memory cell;T-Cell Lymphoma;T-Lymphocyte;Testing;TLR9 gene;TNF gene;Training;translational approach;Translations;Transplantation;treatment strategy;tumor;Tumor Burden;tumor microenvironment;Tumor Suppression;tumor-immune system interactions;Work

PROJECT_TITLE: Local nano-immune modulation for the systemic treatment of lymphoma

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

ORG_CITY: Aurora

ORG_DEPT: NUTRITION

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: PROJECT NARRATIVE Type 2 diabetes (T2D) and other metabolic diseases are becoming increasingly common among youth. Although obesity is a strong risk factor for metabolic dysfunction, only a fraction of youth with obesity develops T2D, suggesting factors beyond obesity are also at play. In this proposal, we will leverage an ongoing, longitudinal, pre-birth cohort study to examine variability in pancreas composition (fat fraction) and size (volume) in adolescence according to individual traits and prior nutrition/growth factors, and whether these pancreatic markers are predictive of dysglycemia onset during puberty.

PI_NAMEs: COHEN, CATHERINE CIOFFI (contact)

PROGRAM_OFFICER_NAME: LINDER, BARBARA

PROJECT_TERMS: Abdomen;abdominal fat;Adolescence;Adolescent;Age;Award;Birth;Body Composition;Body fat;Body mass index;Characteristics;Child;Childhood;Clinical;cohort;Cohort Studies;Colorado;Complement;Complex;Cross-Sectional Studies;Data;demographics;design;Diet;Disease;Doctor of Philosophy;early adolescence;early onset;Enrollment;Environment;Ethnic Origin;experience;falls;Fatty acid glycerol esters;Fatty Liver;Female;Functional disorder;Funding;Glucose;Goals;Growth;Growth Factor;Health;Hepatic;Heterogeneity;Homeostasis;Hour;Human;Image;improved;indexing;Individual;infancy;Infant;insight;Insulin;inter-individual variation;Joints;Knowledge;Life course epidemiology;Life Cycle Stages;lipid transport;Magnetic Resonance Imaging;Malnutrition;Measures;Mediating;Mentors;Mentorship;Metabolic;Metabolic Diseases;Metabolic dysfunction;Mothers;MRI Scans;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Nutritional;Obesity;obesity in children;Observational Study;offspring;OGTT;Onset of illness;Overnutrition;Pancreas;parent grant;Parents;Pathogenesis;Pathway interactions;Phase;Physiological;Play;Population;postnatal;predictive marker;Pregnancy;pregnant;prenatal;prevent;Prevention strategy;programs;Prospective Studies;prospective test;Puberty;Public Health;Research;Research Activity;Risk;Risk Factors;Risk Marker;Role;Scanning;sex;skill acquisition;skills;Time;trafficking;Training;Training Activity;trait;trend;Variant;Visceral;Visit;Youth

PROJECT_TITLE: Pancreatic fat and volume and childhood metabolic health

STUDY_SECTION: DDK

STUDY_SECTION_NAME: Diabetes, Endocrinology and Metabolic Diseases B Study Section[DDK-B]


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cerebrovascular;Congenital Structural Anomalies;Dementia;Dental, Oral, and Craniofacial Disease;Lymphatic Research;Neurodegenerative;Neurosciences;Orphan Drug;Pediatric;Physical Injury - Accidents and Adverse Effects;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Traumatic Head and Spine Injury;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: Los Angeles

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

ORG_STATE: CA

PHR: PROJECT NARRATIVE The brain’s lymphatic system regulates fluid homeostasis and removes toxic macromolecules in brains. The goal of this project is to investigate how the brain lymphatic system can be rejuvenated to treat neurological disorders such as craniosynostosis and Alzheimer’s disease (AD). The outcome will help develop new therapeutic strategies against these devastating neurological diseases.

PI_NAMEs: CHEN, JIANFU  (contact)

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Ablation;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease model;Alzheimer's disease risk;Amyloid beta-Protein;Anatomy;Animal Model;aquaporin 4;Astrocytes;Automobile Driving;Behavior;Behavioral;Blood Vessels;Brain;brain dysfunction;brain parenchyma;Cell Communication;Cells;Cerebrospinal Fluid;cerebrospinal fluid flow;Chotzen Syndrome;Coculture Techniques;Cognitive;Cognitive deficits;cognitive function;Coupled;Craniosynostosis;Data;Defect;Diameter;Drainage procedure;efficacy evaluation;Endothelial Cells;Environmental Risk Factor;Fluid Balance;gain of function;Genes;glymphatic function;glymphatic system;Goals;Growth;Impairment;implantation;improved;Infant;Joint structure of suture of skull;Knowledge;Link;loss of function;Lymphatic;lymphatic dysfunction;Lymphatic Endothelial Cells;Lymphatic function;lymphatic malformations;lymphatic vasculature;lymphatic vessel;macromolecule;Mediating;Mediator;Meningeal lymphatic system;Mesenchymal Stem Cells;Modeling;Molecular;mouse model;Mus;Natural regeneration;Nervous System Disorder;Neurocognitive;Neuroglia;Neurologic;neurotoxic;new therapeutic target;novel therapeutic intervention;Outcome;paracrine;Pathogenesis;Patients;premature;Proliferating;Publishing;Rejuvenation;restoration;ribosome profiling;Risk Factors;Signal Transduction;small molecule;stem cells;Surface;Surgical sutures;Testing;therapeutic target;Translational Regulation;Translations;Traumatic Brain Injury;Vascular Endothelial Growth Factor C;wasting;water channel

PROJECT_TITLE: Brain lymphatic activation for craniosynostosis and Alzheimer’s disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 CN-T (02)]


ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

ORG_CITY: STANFORD

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative Implantable neuroelectronic interfaces have the potential to treat drug-resistant neurological diseases, yet traditional electrode implantation requires invasive open-skull surgery and damages the brain. The pro- posed research aims to address these limitations by developing minimally invasive endovascular neural interfaces capable of monitoring and modulating neural activity. This neuroelectronic platform can be read- ily extended to the detection and treatment of many other models of chronic and progressive neurological diseases, such as Parkinson’s disease, Alzheimer’s disease, epilepsy, and stroke, paving the way to clini- cal translation to the treatment of these conditions in humans.

PI_NAMEs: ZHANG, ANQI  (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Acute;Address;Advisory Committees;Alzheimer's Disease;Anesthesia procedures;Animals;anterior cerebral artery;awake;bioelectronics;Blood coagulation;Blood Vessels;Brain;Brain Injuries;brain tissue;Calcium;Cerebellum;cerebrovascular surgery;Cerebrovascular system;Chemistry;Chronic;clinical translation;Communication;Cortical vasculature;Cortical Vein;cranium;Data;design;Detection;Development;Devices;disease model;Drug resistance;Educational process of instructing;Electrodes;Electrophysiology (science);Engineering;Epilepsy;equity, diversity, and inclusion;experience;experimental study;fabrication;flexibility;Foundations;fundamental research;Goals;Hemorrhage;Histology;Human;Image;Immune response;Implant;implantation;Implantation procedure;in vivo calcium imaging;Infection;Interventional radiology;Knowledge acquisition;manufacture;materials science;Mediation;Mentors;Metals;middle cerebral artery;millimeter;minimally invasive;Mission;Modeling;Monitor;Motor Cortex;National Institute of Neurological Disorders and Stroke;Nervous System Disorder;neural;Neurology;Neurons;Neurosciences;neurosurgery;Occupations;Operative Surgical Procedures;optogenetics;Parkinson Disease;Patients;Persons;Phase;physical science;Polymers;Protocols documentation;Rattus;Research;Research Personnel;Research Project Grants;Resources;Risk;Scientist;Seizures;Sheep;Sigmoid colon;Sinus;skill acquisition;skills;Stents;Stroke;Superior sagittal sinus;Techniques;technology platform;Testing;therapeutic target;Tissues;Training;Universities;Work;Writing

PROJECT_TITLE: Minimally Invasive Endovascular Neural Interfaces for Brain Recording and Modulation

STUDY_SECTION: NST

STUDY_SECTION_NAME: NST-2 Study Section [NST-2]


NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Biotechnology;Breastfeeding, Lactation and Breast Milk;Mental Health;Neurosciences;Pediatric

ORG_CITY: Eugene

ORG_NAME: NEMAMETRIX, INC.

PHR: NARRATIVE This research addresses the urgent need to assess the neurodevelopmental effects of chemicals on public health. By developing a high-throughput zebrafish screening platform, it offers a cost-effective and efficient alternative to conventional methods. Ultimately, the findings from this study have the potential to inform policies, enhance risk assessment, and guide the development of safer chemical alternatives, thereby reducing illness and disability associated with neurotoxic chemical exposures and promoting overall health and well-being.

PI_NAMEs: BROCK, TRISHA ;BRUCKNER, JOSEPH JAMES;PRESTON, MARY A. (contact)

PROJECT_TERMS: Address;Adolescent;Adoption;Adult;Adverse effects;Agriculture;Animal Model;Animals;Anxiety;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavior;Behavioral Assay;Biological Assay;Bioluminescence;Brain;Cells;Central Nervous System;Chemical Exposure;Chemicals;Child;Chronic;Consumption;cost;cost effective;Detection;Development;developmental neurotoxicity;disability;economic cost;Embryo;Engineering;Environment;environmental chemical;Environmental Protection;Equipment and supply inventories;Etiology;Health;Health protection;high throughput screening;Histopathology;Household;Human;improved;Industrialization;innovation;insight;Intervention;knock-down;Lactation;Local Government;Locomotion;Manufacturer;Methods;Modeling;Monitor;morphometry;Mothers;motor behavior;nanoluciferase;Nervous System;neural;neural circuit;neurodevelopment;Neurodevelopmental Disorder;neurodevelopmental effect;Neurologic;neurotoxic;Neurotoxins;overexpression;Performance;Personal Satisfaction;Plasmids;Policies;postsynaptic;Pregnancy;presynaptic;Prevalence;Proteins;Public Health;Rattus;Reader;Regulation;Reporter;Research;response;Risk Assessment;Rodent;Sample Size;screening;Signal Transduction;Social Behavior;Specificity;Synapses;synaptogenesis;Testing;Time;Tissues;Transgenic Organisms;Validation;wasting;Zebrafish

PROJECT_TITLE: The ToxiFin Platform: Advancing High-Throughput Screening and Mechanistic Insights For Developmental Neurotoxicants Using the Zebrafish Model


NIH_SPENDING_CATS: Cerebrovascular;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Neurosciences;Pediatric;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: SAN DIEGO

ORG_NAME: VALA SCIENCES, INC.

PHR: Neurodevelopmental disorders (NDs, including autism, intellectual disabilities, attention-deficit/hyperactivity and others) affect at ~15% of people, appear in childhood/early adulthood, and cannot be cured. Certain pollutants and industrial chemicals cause NDs but predicting whether a chemical will impair brain development is very difficult. Our project will develop assays to identify chemicals that cause NDs; the assays will utilize neurons and related brain cells derived from human stem cells (a type of stem cells derived from adults - no embryos are hurt in the process), will be more predictive than current tests, and will reduce the use of animals in medical research.

PI_NAMEs: GORDON, KARA L (contact)

PROGRAM_OFFICER_NAME: SHAUGHNESSY, DANIEL

PROJECT_TERMS: 3-Dimensional;Adult;adult neurogenesis;Affect;Air Pollutants;Animals;Astrocytes;Attentional deficit;autism spectrum disorder;Biological;Biological Assay;Biological Markers;Blood - brain barrier anatomy;blood-brain barrier function;blood-brain barrier permeabilization;Brain;brain cell;brain endothelial cell;Calcium;Categories;Cell Communication;Cell Cycle;Cells;Chemicals;Child;Childhood;Coculture Techniques;Collection;commercialization;Development;developmental neurotoxicity;Diagnostic and Statistical Manual of Mental Disorders;digital;DSM-V;Embryo;emerging adult;epidemiology study;Epigenetic Process;Evaluation;experience;Exposure to;fetal;Glial Fibrillary Acidic Protein;Government Agencies;Health;HIV;Human;human induced pluripotent stem cells;human stem cells;Hyperactivity;Image Cytometry;impaired brain development;Impairment;in vitro Assay;Induced pluripotent stem cell derived human neuron;Industrialization;Intellectual functioning disability;interest;Kinetics;Life;Link;Medical Research;Mercury;Methods;Microglia;microphysiology system;Microscopy;Mitochondria;Morphology;movie;National Toxicology Program;Neonatal;nerve stem cell;neural;neural circuit;Neurites;Neurodevelopmental Disorder;neurodevelopmental effect;neurogenesis;Neuroglia;neuronal circuit disruption;neuronal circuitry;Neurons;neurotoxic;neurotoxicity;neurovascular unit;novel strategies;Organoids;Outcome;pathogen;Pericytes;Persons;Pesticides;Pharmacologic Substance;Phase;Phenotype;Ploidies;pluripotency;pollutant;Process;Proliferating;Property;Proteins;Protocols documentation;Research;Research Contracts;response;Science;Small Business Innovation Research Grant;small molecule libraries;Standardization;stem cells;Structure;Supporting Cell;Synapses;Testing;Therapeutic;three dimensional cell culture;Tight Junctions;Toxic Environmental Substances;toxicant;Tracer;United States Environmental Protection Agency;voltage

PROJECT_TITLE: An assay suite featuring hiPSC-derived neurons and support cells, to test toxicants and industrial chemicals for developmental neurotoxic effects


ADMINISTERING_IC: CK

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: National Center for Emerging and Zoonotic Infectious Diseases

ORG_CITY: ATHENS

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF GEORGIA

PI_NAMEs: YANG, YANG  (contact)

PROJECT_TITLE: CK22-008, Building Mathematical Modeling Workforce Capacity to Support Infectious Disease and Healthcare Research - 2022


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Cardiovascular;Clinical Research;Neurosciences;Pediatric;Physical Activity;Prevention;Substance Misuse;Underage Drinking

ORG_CITY: PISCATAWAY

ORG_DEPT: MISCELLANEOUS

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: Project Narrative There is an unexplained antagonistic relationship between alcohol use and physical activity, which begins during emerging adulthood. Studies examining the impact of such health-compromising (alcohol use) and health-enhancing (physical activity) behaviors on neurophysiological mechanisms are sparse, and the current study will examine these co-occurring health behaviors on cardiovascular and neural pathways central to self- regulation. The goal is to inform addiction vulnerability and identify brain-body mechanisms that may serve as targets for neuroscience-informed treatment interventions.

PI_NAMEs: UDE, ANDREW ANTONIO (contact)

PROGRAM_OFFICER_NAME: KUMAR, SHAILESH

PROJECT_TERMS: actigraphy;Acute;addiction;Address;Adult;Affect;Age;Alcohol abuse;Alcohol consumption;alcohol cue;alcohol effect;alcohol measurement;alcohol research;alcohol use disorder;Alcohols;Back;Baroreflex;Behavior;Behavior assessment;Behavior Control;Behavioral;binge drinker;binge drinking;Biological;Blood Pressure;Brain;Cardiovascular system;Chronic;chronic alcohol ingestion;college;Communication;critical period;Cross-Sectional Studies;cue reactivity;design;Development;drinking;Electrocardiogram;Electroencephalography;emerging adult;emerging adulthood;Event-Related Potentials;Exercise;Exhibits;experimental study;Foundations;Future;Goals;hazardous drinking;Health;Health behavior;Heart;Heart Rate;heart rate variability;high risk;high risk drinking;improved;incentive salience;Incentives;Individual;Individual Differences;Informal Social Control;Intervention;Interview;Intoxication;Knowledge;life span;Measures;Methodology;Monitor;Motivation;National Institute on Alcohol Abuse and Alcoholism;neural;Neural Pathways;neuromechanism;neurophysiology;Neurosciences;Parents;Patient Self-Report;Pattern;Periodicity;Persons;Physical activity;population health;Process;programs;recruit;Regulation;Research;Resources;Rest;Science;skills;social determinants;Stimulus;Strategic Planning;Testing;timeline;Training;United States National Institutes of Health;Withdrawal;young adult

PROJECT_TITLE: Alcohol use, physical activity, and neurophysiological indicators of behavioral adaptability


NIH_SPENDING_CATS: Cancer;Digestive Diseases;Hematology;Infectious Diseases;Liver Disease;Pancreatic Cancer;Rare Diseases;Sepsis

ORG_CITY: COLD SPRING HARBOR

ORG_NAME: COLD SPRING HARBOR LABORATORY

ORG_STATE: NY

PHR: NARRATIVE Approximately 75% of pancreatic cancer patients who undergo primary tumor resection will develop metastases, and nearly 50% of early postoperative metastases will occur in the liver. We discovered that inflammation from infectious complications during surgery, like sepsis, can influence the ability of pancreatic cancer cells to form liver metastases. In this project, I will determine how sepsis impacts the liver to uncover new therapeutic targets that can block the tumor-promoting effects of perioperative inflammation in order to reduce liver metastasis among resected pancreatic cancer patients.

PI_NAMEs: SIVETZ, NICOLE  (contact)

PROGRAM_OFFICER_NAME: PURI, ANU

PROJECT_TERMS: Address;Adult;anti-tumor immune response;ATAC-seq;Biological Assay;Blood;Bone Marrow;Cancer Patient;cecal ligation puncture;Cells;Cessation of life;Clinical;clinically relevant;Communication;CXCL10 gene;CXCL9 gene;cytotoxicity;Data;Development;Disseminated Malignant Neoplasm;Endotoxemia;Endotoxins;Epigenetic Process;Excision;experience;experimental study;Genes;Health;Human;Immune;Immune response;Immunity;Immunosuppression;Incidence;Infiltration;Inflammation;Injections;Knowledge;Lesion;Link;Lipopolysaccharides;Liver;Malignant neoplasm of pancreas;Malignant Neoplasms;Metastatic Neoplasm to the Liver;Modeling;mortality risk;mouse model;Mus;Myeloid Cells;Natural Killer Cells;Neoplasm Metastasis;neutrophil;new therapeutic target;Operative Surgical Procedures;Pancreas Transplantation;pancreatic cancer cells;pancreatic cancer patients;Pancreatic Ductal Adenocarcinoma;pancreatic ductal adenocarcinoma cell;Patients;Perioperative;Plasma;polymicrobial sepsis;Postoperative Period;Predisposition;Preventive therapy;Primary Neoplasm;Prognostic Factor;Receptor Signaling;Recurrence;Reporting;Resected;response;Risk;Role;Sepsis;septic patients;Signal Transduction;single-cell RNA sequencing;Site;Sterility;Testing;Therapeutic;therapeutic target;TLR4 gene;Toll-like receptors;transcriptome sequencing;Transgenic Mice;tumor;Tumor Promotion;tumor-immune system interactions;Up-Regulation

PROJECT_TITLE: The impact of sepsis-induced inflammation on pancreatic cancer liver metastasis


NIH_SPENDING_CATS: Clinical Research;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: SURGERY

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE The proposed U01 is relevant to public health because it will build on foundational work conducted in the first phase of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium to establish the necessary evidence base for future bladder health promotion and lower urinary tract symptoms (LUTS) prevention interventions in adolescent and adult women. Progress towards this goal is critical to reduce the large public health burden of poor bladder health and LUTS.

PI_NAMEs: SUTCLIFFE, SIOBHAN  (contact)

PROGRAM_OFFICER_NAME: KIRKALI, ZIYA

PROJECT_TERMS: Address;adolescent woman;Adult women;Affect;Behavior;Behavioral;Biological;Bladder;Chronic;Clinical Research;Cohort Analysis;Cohort Studies;Communities;community partners;Complement;cost;Cross-Sectional Studies;Data;design;Deterioration;Development;Diagnosis;Ecology;Education;Educational Intervention;Educational Models;epidemiologic data;Epidemiology;Etiology;Evaluation;evidence base;experimental study;Female;Focus Groups;follow-up;Foundations;Future;Goals;Health;Health Promotion;High Prevalence;implementation study;incontinence symptom;Individual;innovation;insight;Institution;Intervention;intervention delivery;intervention mapping;Intervention Studies;Investigation;Knowledge;Life Cycle Stages;lower urinary tract symptoms;Maintenance;Measures;medical schools;member;Meta-Analysis;Methods;Nature;observational cohort study;Pain;Patient Self-Report;Persons;Phase;Population;population based;preference;Prevention;preventive intervention;prospective;protective factors;Public Health;Publishing;Quality of life;Research;Risk;Risk Factors;Series;Site;social;systematic review;Time;tool;Universities;Urinary Incontinence;Washington;Woman;Work

PROJECT_TITLE: Bladder health promotion and LUTS prevention inadolescent and adult women across the life course


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: PROJECT NARRATIVE Endophthalmitis, a bacterial infection inside the eye, can quickly lead to permanent vision loss. Bacteria need iron to survive, so immune cells may overload themselves with iron to keep it away from them. This proposal examines whether iron chelation could be an effective anti-bacterial and anti-inflammatory treatment for endophthalmitis.

PI_NAMEs: FOSHE, SIERRA  (contact)

PROGRAM_OFFICER_NAME: AGARWAL, NEERAJ

PROJECT_TERMS: Acute;Animal Model;Anti-Bacterial Agents;Anti-Inflammatory Agents;Antibiotic Resistance;Antibiotics;Bacteria;bacterial endophthalmitis;Bacterial Infections;Binding;Blindness;Cell Proliferation;Cell Survival;Cells;Central Nervous System Infections;Clinical;cohort;Colony-forming units;Complication;cytokine;Data;Disease;Dose;Drug Kinetics;effectiveness evaluation;Endophthalmitis;Excision;Eye;Genes;Goals;Growth;Histology;Hour;Image;Immune;immune activation;improved;In Situ;In Vitro;in vivo;Infection;Inflammation;Inflammatory;Inflammatory Response;Injections;Injury;Invaded;Iron;Iron Chelating Agents;Iron Chelation;Iron Overload;Lead;Left;Leukocytes;Link;Liquid substance;Macrophage;Mass Spectrum Analysis;Microglia;Modeling;mouse model;Mus;Natural regeneration;Neurons;neurotoxic;operation;Operative Surgical Procedures;Oxidative Stress;pathogenic bacteria;Patient-Focused Outcomes;Patients;Predisposition;preservation;prevent;Proliferating;pyridine;Regulation;Regulator Genes;response;Retina;Retinal Degeneration;Retinal Detachment;Retinal Diseases;Role;Saline;Sorting;Stains;Staphylococcus aureus;Staphylococcus aureus infection;Sterility;Structure;Surgical complication;Symptoms;Testing;Time;Tissues;translational applications;uptake;Virulence;Visualization;Wild Type Mouse

PROJECT_TITLE: The role of iron in retinal degeneration during bacterial infection


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Pediatric;Prevention;Rural Health;Social Determinants of Health;Urologic Diseases;Women's Health Research

PHR: PROJECT NARRATIVE PENN+PLUS CRC (PENN+PLUS), an exceptional team of interdisciplinary investigators, has made significant progress over the past 5 years, producing 11 articles published or in press, 6 submitted manuscripts, and 26 refereed national and international presentations.

PI_NAMEs: NEWMAN, DIANE K.;SMITH, ARIANA L (contact)

PROJECT_TERMS: Address;Adolescent;Adolescent Behavior;adolescent woman;Behavior;behavior measurement;Biological;Bladder;Caffeine;Clinical;clinical center;Clinical Research;cohort;Cohort Studies;Collaborations;Communities;community based participatory research;community engagement;community partners;cost outcomes;Data;design;Device or Instrument Development;Disease;Education;Elements;Epidemiology;Ethnic Origin;evidence base;experience;Female Adolescents;Focus Groups;Future;Geography;Health;Health behavior;Health Care Costs;Health Promotion;Healthcare;Hospitals;Hygiene;implementation science;improved;Individual;innovation;instrument;Intake;International;Intervention;Intervention Studies;Lead;Leadership;life span;Life Style;Liquid substance;Literature;Location;Longitudinal cohort study;Lower urinary tract;lower urinary tract symptoms;Manuscripts;marginalization;Measures;member;Menstruation;Methodology;novel;novel strategies;Outcome;Patient-Focused Outcomes;Pelvis;Pennsylvania;Phase;Physical activity;pilot test;population based;Positioning Attribute;prevent;Prevention;Prevention approach;preventive intervention;Productivity;programs;Prospective Studies;protective behavior;protective effect;Public Health;Publications;Publishing;Questionnaires;Race;Research;Research Methodology;Research Personnel;Resources;Review Literature;Risk;Rural;rural area;sample collection;Science;Self Care;Self Medication;Site;socioeconomics;Specialist;Structure;success;Surveys;System;Technology;Time;tool;Universities;urban area;Weight maintenance regimen;Woman;Work

PROJECT_TITLE: Penn+Plus Clinical Research Center


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Behavioral and Social Science;Digestive Diseases;Infectious Diseases;Neurosciences;Prevention

ORG_CITY: LOS ANGELES

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE Soil-transmitted gastrointestinal helminths (e.g., the human-infective threadworm Strongyloides stercoralis and hookworms in the genera Necator and Ancylostoma) infect over one billion individuals globally, with the burden of disease disproportionately impacting disadvantaged communities with poor sanitation infrastructure. Soil- transmitted helminths rely upon sensory cues to navigate various environments, participate in host seeking, and complete their parasitic life cycle. This proposal seeks to define the role of ambient oxygen as a neuronally detected chemosensory cue in S. stercoralis (i.e., a uniquely genetically tractable soil-transmitted helminth) and identify molecular pathways in the parasite oxygen-sensing machinery vulnerable to chemotherapeutic targeting.

PI_NAMEs: WALSH, BREANNA M. (contact)

PROGRAM_OFFICER_NAME: MCGUGAN, GLEN C

PROJECT_TERMS: Adult women;Afferent Neurons;Ancylostoma (genus);Anthelmintics;Atmosphere;Behavior;Behavioral;Behavioral Assay;behavioral response;Biology;burden of illness;Caenorhabditis elegans;Calcium;Carbon Dioxide;Clinical Management;Communicable Diseases;Communities;Coughing;CRISPR/Cas technology;Cues;Data;Dedications;Deglutition;design;Development;Disease;Drosophila melanogaster;Ectopic Expression;egg;Enterobius;Environment;Esthesia;Etiology;Excretory function;Exhibits;Exposure to;Feces;gastrointestinal;gastrointestinal infection;Gastrointestinal tract structure;Genetic;Genetic Transcription;Goals;hatching;Helminths;high risk;Hookworms;Human;Image;Imaging Techniques;Immunocompromised Host;immunosuppressed;In Vitro;Individual;Indolent;Infrastructure;insight;interest;Intervention;intestinal villi;Intestines;Invertebrates;Laboratory Study;Larva;Life;Life Cycle Stages;Lung;Measures;Mediating;Medical;Mentorship;Modeling;Molecular;Molecular Biology;Molecular Target;Morbidity - disease rate;mortality;Motility;Movement;Mutagenesis;Necator;neighborhood disadvantage;Nematoda;Nematode infections;neural;Neuroanatomy;Neurobiology;Neurons;Neurosciences;Neurosciences Research;novel;novel strategies;Oxygen;Parasites;Parasitic nematode;parasitism;Parasitology;Pathway interactions;Penetration;Persons;Physicians;Population;Predisposition;prevent;Process;Proliferating;Property;Protein Sequence Homologs;Reporter;Resistance;Resource-limited setting;respiratory;response;Role;Sanitation;Scientist;sensor;Sensory;sensory mechanism;Signal Transduction;skills;Skin;Soil;Soluble Guanylate Cyclase;Strongyloides stercoralis;Strongyloidiasis;Surface;Syndrome;System;Techniques;Temperature;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;Training;transmission process;Trees;Work

PROJECT_TITLE: Oxygen sensation in human-parasitic skin-penetrating nematodes


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Digestive Diseases;Genetics;Human Genome;Pancreatic Cancer;Rare Diseases

ORG_CITY: CHAPEL HILL

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Pancreatic cancer is an aggressive disease that is frequently diagnosed in late stages after metastasis has occurred, highlighting the need for a better understanding of early transformation events and tumorigenic mechanisms. Completion of this research proposal will help address this gap in knowledge by revealing the functional contribution of a de novo expressed gastric protein, Gastrokine 2, which is hypothesized to play a tumor suppressive role in pancreatic tumor progression. Knowledge gained from studies could impact biomarker development with the potential for therapeutic intervention.

PI_NAMEs: BELL, WHITNEY JEAN (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Address;Adult;Affect;Anti-Inflammatory Agents;axon guidance;Biological Assay;biomarker development;cancer cell differentiation;Cancer Etiology;cancer initiation;Cell Differentiation process;Cell Line;Cell Proliferation;Cells;Cellular Morphology;Cessation of life;Color;Confocal Microscopy;cytokine;Data;Development;Diagnosis;differential expression;Differentiation and Growth;Disease;Disease Progression;Doxycycline;Duct (organ) structure;Epithelial Cells;Epithelium;Etiology;Event;experimental study;Family member;gastric foveola;Gene Expression;Genes;Genetic Markers;Goals;Histologic;histological stains;Homeostasis;Human;immunocytochemistry;Immunofluorescence Immunologic;Immunohistochemistry;In Vitro;in vivo;inducible gene expression;inhibitor;insight;Interleukin-12;interleukin-23;Invaded;Kinetics;knock-down;Knowledge;KRAS oncogenesis;Lesion;Lesion by Stage;loss of function;Maintenance;Malignant neoplasm of pancreas;Malignant Neoplasms;malignant stomach neoplasm;men;Mesenchymal;Metaplastic Cell;Metaplastic Epithelial Cell;Modeling;Molecular Biology Techniques;molecular subtypes;Mucins;Mucous Membrane;Mus;mutant;Neoplasm Metastasis;neoplastic;neoplastic cell;Operative Surgical Procedures;Organoids;Pancreas;pancreatic cancer cells;Pancreatic Diseases;Pancreatic Ductal Adenocarcinoma;pancreatic neoplasm;pancreatic tumorigenesis;Pathological Staging;patient prognosis;Pattern;Phenotype;Play;Population;premalignant;programs;protein expression;Proteins;Regulation;Reporting;Research;Research Proposals;Role;Signal Pathway;Signal Transduction;single-cell RNA sequencing;small hairpin RNA;Source;Specific qualifier value;Staging;Stains;statistics;Stomach;Surface;Survival Rate;System;Testing;TFF1 gene;Therapeutic Intervention;TP53 gene;Training;transcriptome sequencing;treatment response;tumor;tumor growth;tumor progression;Tumor Subtype;Tumor Volume;Tumor Weights;tumorigenic;United States;Up-Regulation;Western Blotting;Woman;Work

PROJECT_TITLE: Role of Gastrokine 2 in pancreatic cancer development


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Gene Therapy;Genetics;Immunotherapy;Nanotechnology;Orphan Drug;Ovarian Cancer;Rare Diseases;Women's Health Research

ORG_CITY: SEATTLE

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative It is of key interest in cancer research to create ways to reprogram tumor-associated macrophages (TAMs) from a pro-tumor (M2-like) to an anti-tumor (M1-like) phenotype and thereby induce immune effects that can bring about tumor regression. However, at present, there are no methods that can enable physicians to rationally and selectively reprogram TAMs for therapeutic purposes. In this proposal, we are optimizing an off- the-shelf nanodrug that carries in vitro-transcribed mRNA to genetically reprogram immunosuppressive macrophages (M2-like TAMs) to express tumor-clearing (M1-like) phenotypes as a new approach to treat otherwise incurable ovarian cancer and, ultimately, other types of malignancies as well.

PI_NAMEs: STEPHAN, MATTHIAS  (contact)

PROGRAM_OFFICER_NAME: SINGH, ANJU

PROJECT_TERMS: Ablation;Acute;Animals;anti-cancer research;Antibodies;Autopsy;Biological Assay;Blood Chemical Analysis;Cancer Patient;Chemoresistance;Clinic;Clinical;clinical practice;Clinical Trials;Coagulation Process;Collaborations;Communication;Complement Activation;cytokine;Dangerousness;Data;design;Dose;Ensure;experimental study;Filtration;Fred Hutchinson Cancer Research Center;Funding;Genes;Genetic;Genetic Transcription;Glioblastoma;Goals;Good Manufacturing Process;Hour;Human;Immune;Immunological Models;immunosuppressive macrophages;immunotoxicity;In Vitro;in vitro Assay;in vivo;Inflammatory;Infusion procedures;Injectable;interest;Interferons;Intervention;Investigational New Drug Application;Knowledge;Laboratories;Late Effects;Macaca fascicularis;Macrophage;Malignant neoplasm of ovary;Malignant Neoplasms;manufacturing scale-up;Measurement;Medical;Messenger RNA;Methods;Microfluidics;Modeling;Mus;nanocarrier;nanodrug;nanoformulation;nanomedicine;nanoparticle;Nanotechnology;nanotherapeutic;Nature;new therapeutic target;novel;novel strategies;Outcome;Pharmaceutical Preparations;Phase I Clinical Trials;Phenotype;Phosphotransferases;Physicians;Platelet aggregation;Polymers;porcine model;pre-clinical;pre-Investigational New Drug meeting;Primates;Production;programs;Protocols documentation;Reaction;Regulation;Research;research clinical testing;Research Personnel;Risk;Safety;Schedule;side effect;small molecule;Sterility;success;System;systemic inflammatory response;systemic toxicity;Technology;Testing;Therapeutic;Toxic effect;Toxicity Tests;transcription factor;Translating;tumor;Tumor Immunity;Tumor Promotion;Tumor-associated macrophages;Work

PROJECT_TITLE: Developing macrophage reprogramming mRNA nanocarriers for initial clinical testing


NIH_SPENDING_CATS: Bioengineering;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Cost Effectiveness Research;Digestive Diseases;Health Services;Orphan Drug;Pancreatic Cancer;Prevention;Radiation Oncology;Rare Diseases

ORG_CITY: Morrisville

ORG_NAME: CIVATECH ONCOLOGY, INC.

PHR: With NIH/NCI SBIR support, CivaTech Oncology developed CivaSheet®, the only directional intraoperative radiation device to deliver a curable radiation dose to microinvasive disease at the surgical margin while protecting healthy tissues. Phase I/II clinical trials for pancreatic cancer demonstrate no device related toxicity and 0% local recurrence. Controlling localized pancreatic cancer is the first step to providing better outcomes for these difficult to treat patients. To enable patients the best possible outcomes, we request funds to expand patient access to CivaSheet by evaluating cost outcomes, applying for reimbursement coverage, and engineering support to scale manufacturing.

PI_NAMEs: PEREZ, KRISTY  (contact)

PROGRAM_OFFICER_NAME: CONNORS, BRITTANY SEAN

PROJECT_TERMS: Abdomen;Address;Adverse event;Affect;American;Automation;Award;Awareness;Blood Vessels;Brachytherapy;Brachytherapy Seeds;cancer diagnosis;Caring;Clinical;Clinical Trials;combination cancer therapy;commercialization;Conduct Clinical Trials;cost;Cost Analysis;cost outcomes;COVID-19 pandemic effects;Data;Data Analyses;Devices;Diagnosis;Discipline of Nuclear Medicine;Disease;disorder control;Dose;dosimetry;Duodenum;economic evaluation;economic outcome;Electromagnetic Energy;Eligibility Determination;Encapsulated;Engineering;Excision;Funding;Generations;Goals;Grant;Health;health care economics;health economics;Healthcare Systems;Hospitals;Implant;improved;improved outcome;Industry;innovation;Kidney;Liver;Local Therapy;Localized Disease;Localized Malignant Neoplasm;Malignant neoplasm of pancreas;Malignant Neoplasms;manufacturability;manufacture;manufacturing capabilities;manufacturing process;manufacturing scale-up;manufacturing systems;Marketing;Membrane;microchip;Microinvasive;minimally invasive;Mission;Neutrons;North Carolina;novel;Nuclear Reactors;Oncology;Operative Surgical Procedures;Organ;Outcome;Overdose;Palladium 103;Pancreas;pancreatic cancer patients;Patients;Phase;Phase I/II Clinical Trial;Physics;Polymers;prevent;Privatization;Process;Production;professor;programs;Publications;Quality of life;Radiation;radiation delivery;Radiation Dose Unit;Radiation therapy;Radiation Tolerance;Radioactive;Recurrence;Recurrent disease;Request for Proposals;Resected;Retroperitoneal Space;screening;seal;Shapes;Side;Small Business Innovation Research Grant;Source;Stomach;Structure;success;Surgical margins;Survival Rate;System;Techniques;Testing;Time;Tissues;Toxic effect;tumor;United States;United States National Institutes of Health;Universities;Vendor;Work

PROJECT_TITLE: Commercializing CivaSheet for Pancreatic Cancer Patients


ED_INST_TYPE: SCHOOLS OF NURSING

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Prevention;Social Determinants of Health;Urologic Diseases;Women's Health Research

ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE: Currently, data are not available that can inform adolescent and adult women on recommendations for beverage intake pattern(s) that aid in achieving optimal bladder health. We aim to identify best beverage intake pattern(s) for preventing lower urinary tract symptoms across the life course by using an innovative mobile device application for collecting information in real time, along with a more traditional population-based survey study. Ultimately, we want to know how adolescent and adult women can optimize intake patterns to be most conducive to a truly healthy bladder, with lowest risk for developing lower urinary tract symptoms.

PI_NAMEs: LOW, LISA KANE (contact)

PROJECT_TERMS: Address;Adolescent;adolescent woman;Adult;Adult women;Affect;Attitude;Behavior Therapy;Belief;Beverages;Biological;Biological Factors;Biometry;Bladder;Body Fluids;Chronic;clinical practice;Communities;community engagement;Complex;Cues;Data;Data Collection;Data Set;drinking;Environment;Environmental Risk Factor;environmental stressor;Epidemiologist;Epidemiology;Equilibrium;Evidence based intervention;Excretory function;Exercise;experience;Family Nursing;Focus Groups;Food;Future;Goals;Habits;handheld mobile device;Health;Health behavior;health communication;health definition;innovation;insight;Intake;Intervention;Investments;Knowledge;Lead;Learning;Life Cycle Stages;Lived experience;longitudinal analysis;longitudinal dataset;Longitudinal Studies;lower urinary tract symptoms;Measures;medical specialties;Medicine;Methods;Michigan;mobile application;Monitor;Nurse Midwives;Nurse Practitioners;Nurses;Nutritional;Observational Study;Occupational;Pathway interactions;Pattern;Pelvis;Personal Satisfaction;physical state;Physicians;Physiological;population based;prevent;Prevention;Prevention strategy;Preventive Medicine;Primary Care;protective factors;Psyche structure;Public Health;Publishing;Qualitative Methods;Readiness;Recommendation;Research;Resources;Risk;Risk Factors;Scientist;social;social culture;Social Well-Being;sociocultural determinant;Surveys;Symptoms;Telephone;Testing;Time;tool;Travel;Universities;urinary;Urine;Variant;Woman;Work

PROJECT_TITLE: The Truly Healthy Bladder 2: Understanding Normal As A Pathway To Prevention Of Lower Urinary Tract Symptoms In Women


ORG_CITY: Nashville

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE – Overall This application proposes the continuation of the Biomolecular Multimodal Imaging Center (BIOMIC) at Vanderbilt University, a Tissue Mapping Center associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of BIOMIC is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of human tissues. The application of these technologies to the human kidney will provide a new paradigm of understanding the normal state of this organ across multiple dimensions, both molecular (e.g., lipids, metabolites, proteins, and RNA) and spatial (e.g., whole organs to single cells).

PI_NAMEs: CAPRIOLI, RICHARD M;SPRAGGINS, JEFFREY M (contact)

PROGRAM_OFFICER_NAME: BRUNSKILL, ERIC WAYNE

PROJECT_TERMS: 3-Dimensional;Academic Medical Centers;Age;Anatomy;Applications Grants;Atlases;biocomputing;Biomedical Research;Body System;cell type;Cells;chemical fixation;Clinical;Clinical Data;Collaborations;Collection;Communities;Cooperative Human Tissue Network;Data;Data Analyses;data integration;Data Set;demographics;Development;Dimensions;Disease;Ensure;Environment;ex vivo imaging;Eye;Freezing;Funding;Generations;Goals;Health;Histologic;Histology;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging facilities;imaging modality;Imaging technology;Immunofluorescence Microscopy;improved;in vivo;Infrastructure;innovation;insight;International;Ischemia;Kidney;Knowledge;Laboratories;Lipids;Maps;mass spectrometric imaging;Mass Spectrum Analysis;Medical center;Medical Imaging;Medicine;member;Microscopy;Mission;Modality;Molecular;Molecular Analysis;Monitor;multidisciplinary;multimodal data;Multimodal Imaging;multimodality;National Center for Research Resources;Nephrectomy;Netherlands;novel;Organ;Pancreas;Participant;Performance;Phenotype;Physicians;Positioning Attribute;preservation;Procedures;Process;programs;Proteins;Proteomics;quality assurance;Quality Control;Race;Reproducibility;Research;Research Personnel;Resolution;Resources;RNA;Sampling;Scientist;Selection Criteria;sex;single nucleus RNA-sequencing;single-cell RNA sequencing;Specimen;Stains;Standardization;Surface;System;Techniques;Technology;Testing;Time;Tissue Donors;tissue mapping;Tissues;Transcript;transcriptome sequencing;transcriptomics;Transplantation;United States National Institutes of Health;Universities;Work

PROJECT_TITLE: Vanderbilt University Biomolecular Multimodal Imaging Center for 3-Dimensional Mapping of the Human Kidney


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Data Science;Kidney Disease;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD)

PHR: PROJECT NARRATIVE – Data Analysis Core This application proposes the continuation of the Biomolecular Multimodal Imaging Center (BIOMIC) at Vanderbilt University, a Tissue Mapping Center associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of BIOMIC is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of human tissues. The goal of the BIOMIC Data Analysis Core is to develop the computational resources and workflows necessary to construct a molecular atlas of 3-dimensional multimodal molecular data by continuing the established, successful collaborative team at Vanderbilt University and Delft University of Technology.

PI_NAMEs: SPRAGGINS, JEFFREY M (contact)

PROJECT_TERMS: 3-Dimensional;Age;Anatomy;Atlases;automated segmentation;Biological;Biological Assay;Cell Cycle;cell type;Cells;Chemicals;Classification;Clinical;cohort;Communities;Computer software;computerized data processing;computing resources;Cues;Data;Data Analyses;data integration;data mining;Data Set;Data Sources;demographics;Development;Dimensions;Dropout;explainable artificial intelligence;explainable machine learning;Eye;Gender;Gene Expression;Goals;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging facilities;Imaging technology;Individual;insight;interest;Kidney;Label;Learning;Machine Learning;Magnetic Resonance Imaging;Maps;Masks;Measurement;Medical Imaging;member;Memory;Methods;Microscopy;Mining;Mission;Modality;Modeling;Molecular;Molecular Analysis;multimodal data;Multimodal Imaging;multimodality;multiple omics;Nature;Nephrons;open source;Organ;Pancreas;Population;Procedures;Process;Production;Proteomics;Published Comment;Quality Control;Reporting;Research;Resolution;Resources;Sampling;Scheme;spatial integration;spatiotemporal;Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization;Speed;Technology;Tissue Donors;tissue mapping;Tissue Sample;Tissues;transcriptomics;Universities;Variant;Visualization;Work;X-Ray Computed Tomography

PROJECT_TITLE: Data Analysis Core

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMST-U]


PHR: PROJECT NARRATIVE – Kidney OSP This application proposes the continuation of the Biomolecular Multimodal Imaging Center (BIOMIC) at Vanderbilt University, a Tissue Mapping Center associated with the Human BioMolecular Atlas Program (HuBMAP). The mission of BIOMIC is to build a platform of integrated technologies for imaging and molecular analysis that enables the construction of comprehensive 3-dimensional molecular atlases of human tissues. The Kidney OSP aims to 1) procure and manage human tissue specimens, 2) determine and mitigate non-biological pre-analytical factors, and 3) develop scalable multimodal imaging and deep multi-omic assays for the human kidney.

PROJECT_TERMS: 3-Dimensional;Address;Affect;analysis pipeline;Anatomy;Antibodies;assay development;Atlases;automated segmentation;biobank;Biological Assay;Biological Markers;Blood capillaries;blood pressure control;Cell Separation;cell type;Cells;Characteristics;Clinical;Collection;Cytometry;Data;Data Analyses;data management;Disease;Dissociation;Distal;Duct (organ) structure;Elements;Emerging Technologies;Excision;Exclusion;experimental study;extracellular;Filtration;Fluorescence;Gene Expression Profiling;Goals;Heterogeneity;Histologic;Homeostasis;Human;Human BioMolecular Atlas Program;human tissue;Image;imaging facilities;Imaging technology;Immunofluorescence Microscopy;Individual;insight;interstitial;Kidney;kidney cell;Knowledge;Link;Lipids;Location;Lymphatic;Maps;mass spectrometric imaging;Methods;Microscopy;Mission;Modality;Molecular;Molecular Analysis;molecular imaging;Molecular Profiling;Morphology;Multimodal Imaging;multimodality;multiple omics;Neighborhoods;Nephrons;Operative Surgical Procedures;Organ;Preparation;programs;Property;Proteins;Proteomics;Protocols documentation;Quality Control;Research Personnel;RNA;Sampling;scale up;single-cell RNA sequencing;Sodium Chloride;Source;Specimen;Stains;Standardization;Structure;surgery material;Tissue Banks;tissue mapping;Tissue Sample;Tissues;transcriptomics;Tubular formation;Universities;Water


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Clinical Research;Clinical Trials and Supportive Activities;Diabetes;Dissemination and Implementation Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Networking and Information Technology R&D (NITRD);Racial and Ethnic Minority Health Research;Telehealth

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Latino populations have a high burden of type II diabetes leading to worse health outcomes. Telemedicine has been shown to improve diabetes outcomes but is under-utilized among Latino patients. To inform telemedicine implementation strategies and improve care, the proposed research will develop a multilevel, culturally tailored intervention to promote telemedicine use among Latino patients with diabetes.

PI_NAMEs: RODRIGUEZ, JORGE A (contact)

PROGRAM_OFFICER_NAME: WHITE, DOLLY PENN

PROJECT_TERMS: Address;Affect;Age;behavior change wheel;Biological;Caring;Clinic;Clinical;Clinical Trials;Complications of Diabetes Mellitus;COVID-19;culturally appropriate intervention;Data;Data Collection;design;Diabetes Mellitus;Diagnosis;Diamond;Disparity;disparity reduction;E-learning;Electronic Health Record;Ensure;Equity;Ethnography;Evaluation;experience;glycemic control;Goals;Grant;health information technology;Healthcare Systems;heuristics;human centered design;implementation intervention;implementation science;implementation strategy;improved;Incidence;Inequity;innovation;Intervention;Latino;Latino Population;Limited English Proficiency;Linguistics;Logistic Regressions;Long-Term Care;Maps;Mentorship;Methodology;Modeling;Motivation;Neighborhoods;Non-Insulin-Dependent Diabetes Mellitus;Outcome;Patients;Persons;poor health outcome;Positioning Attribute;prevent;primary outcome;Process;Randomized, Controlled Trials;Reach, Effectiveness, Adoption, Implementation, and Maintenance;recruit;remote visit;Research;Research Personnel;Resources;Risk;skills;social factors;Technology;Telemedicine;Telephone;Testing;therapy development;tool;Training;trial design;usability;video visit;Visit;Work

PROJECT_TITLE: Toward Technology Equity: Extending Telemedicine to Latino Patients with Type II Diabetes


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Women's Health Research

ORG_CITY: Newark

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: RUTGERS BIOMEDICAL AND HEALTH SCIENCES

PHR: By elucidating the mechanisms of radio-resistant DNA synthesis and the role of the BRCA2 tumor suppressor in DNA replication upon DNA damage, this study will advance our understanding of cellular response to DNA damaging agents and tumor relapse after the treatments. Results from this study may provide a scientific basis for the rational design of novel approaches to prevent therapy-induced cancer development and tumor relapse after radiation and chemotherapy.

PI_NAMEs: XIA, BING  (contact)

PROGRAM_OFFICER_NAME: WEINREICH, MICHAEL DALE

PROJECT_TERMS: Aftercare;Alleles;Binding;BRCA2 gene;Breast;Breast Cancer Cell;Breast Cancer Model;Breeding;cancer cell;Cancer Etiology;cancer therapy;carcinogenesis;CDC45L gene;Cell Cycle Checkpoint;Cells;Chemotherapy and/or radiation;Chromatin;Cisplatin;Complex;conditional knockout;Coupled;Defect;Development;DNA;DNA biosynthesis;DNA Damage;DNA Double Strand Break;DNA polymerase A;DNA Polymerase I;DNA Primase;DNA Repair;DNA Replication Damage;DNA Replication Factor;DNA replication fork;Double Strand Break Repair;Family;Genes;Genome;genome integrity;Genome Stability;Genomic Instability;Germ-Line Mutation;helicase;homologous recombination;Induced Mutation;inhibitor;insight;Kinetics;Malignant neoplasm of ovary;Malignant Neoplasms;Mammals;Mammary Tumorigenesis;Maps;MCM10 gene;MCM2 gene;Mediating;member;Mitotic;Modality;mutant;Mutant Strains Mice;Mutation;novel strategies;Ovarian;overexpression;Pancreas;Pathway interactions;Pattern;Phenotype;Physiological;Platinum;Play;Poly(ADP-ribose) Polymerases;Polymerase;prevent;Process;Prognosis;Proteins;Radiation;radiation response;radioresistant;rational design;recruit;Regulation;Relapse;repaired;Replication Error;Replication Initiation;Replication Origin;replication stress;Reporting;Resistance;response;restraint;Role;S phase;Salts;Second Primary Cancers;Single-Stranded DNA;Site;skip lesion;Testing;Time;Travel;treatment response;triple-negative invasive breast carcinoma;tumor;Tumor Suppression;Tumor Suppressor Proteins;tumorigenesis;Xenograft Model

PROJECT_TITLE: Regulation of DNA replication kinetics by BRCA2 after DNA damage

STUDY_SECTION: RTB

STUDY_SECTION_NAME: Radiation Therapeutics and Biology Study Section[RTB]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Clinical Trials and Supportive Activities;Dissemination and Implementation Research;Eye Disease and Disorders of Vision;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Primary Health Care;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE Despite effective treatments and guidelines for care, glaucoma is the leading cause of blindness in Black Americans and represents a major disparity in health and health care. The proposed research advances public health by taking a community-engaged, population health approach to address the substantial public health gap between well-established guidelines for detecting and treating glaucoma and studies that document applications of these guidelines. This project aligns well with the missions of the NIH, NEI and National Academy of Medicine (NAM), as it works toward the elimination of preventable vision loss by approaches that go beyond the typical clinical setting.

PI_NAMEs: ELAM, ANGELA R (contact)

PROGRAM_OFFICER_NAME: JOHNSON, JARRETT AINSWORTH

PROJECT_TERMS: Academy;acceptability and feasibility;Address;Age;arm;Award;behavior change;Black American;Black Populations;blind;Blindness;care providers;career;Caring;caucasian American;Chronic Disease;Church;Clinical;combat;Communities;community based treatment;community engaged intervention;community engagement;Community Health;Community Health Aides;Data;design;Detection;Diagnosis;Disease;Disparity;disparity reduction;Education;effective therapy;empowerment;Ethnic Origin;Ethnic Population;Etiology;Evaluation;evidence based guidelines;Eye;Face;Faith;faith-based intervention;Faith-based organization;Family history of;Foundations;Geography;Glaucoma;Goals;Guidelines;health care service;health care service utilization;Health Disparities Research;health disparity;Healthcare;high risk;high risk population;implementation framework;implementation science;implementation strategy;improved;Individual;innovation;Intervention;Interview;Knowledge;Link;marginalized population;Medicine;member;Methods;Mission;motivational enhancement therapy;novel;ophthalmic examination;Ophthalmologist;Outcome;patient-clinician communication;Pattern;personalized approach;Persons;Pilot Projects;population health;Preventive healthcare;programs;Public Health;Race;Randomized Controlled Clinical Trials;recruit;Religion;Research;Risk;Scientist;screening;Site;skill acquisition;social;socioeconomics;Structure;success;tailored messaging;Techniques;therapy design;Training;Trust;United States;United States National Institutes of Health;Visual impairment;Work

PROJECT_TITLE: Increasing Eye Care Utilization in Black Americans At High Risk For Glaucoma Using A Community-Engaged and Faith-Based Intervention