ADMINISTERING_IC: ES

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Endocrine Disruptors;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Effects of Indoor Air Pollution;Human Genome;Lung;Lung Cancer;Prevention;Tobacco;Tobacco Smoke and Health

ORG_CITY: ALBANY

ORG_DEPT: BIOLOGY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT ALBANY

ORG_STATE: NY

PHR: NARRATIVE Cigarette smoke is a complex mixture of toxicants that can damage DNA and promote many diseases. The goal of this project is to define how mice reprogram 37 different RNA modifications comprising their tRNA-specific epitranscriptome to regulate translation in response to environmental tobacco smoke (ETS). We have recently discovered a new mechanism of translational regulation in response to stress, in which toxicant exposures cause highly predictive changes in dozens of modified ribonucleosides in the RNA machinery that regulates protein levels, leading to selective translation of codon-biased mRNAs representing families of genes critical for surviving the stress. Using novel mouse genetic models, we will test our proposed mechanism of translational control, define the ETS-programmable epitranscriptome, and determine the importance of RNA modification reprogramming in response to ETS. The results will have major implications for our understanding of tissue and cellular responses to cigarette smoke and they will be broadly applicable to other toxicants and pharmaceuticals. !

PI_NAMEs: BEGLEY, THOMAS J (contact)

PROGRAM_OFFICER_NAME: TYSON, FREDERICK L

PROJECT_TERMS: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone;Alkylating Agents;Alkylation;Anticodon;Aromatic Polycyclic Hydrocarbons;Arsenic;Automobile Driving;Bacteria;Benzo(a)pyrene;biological adaptation to stress;Cadmium;Cardiovascular Diseases;cell behavior;Cell Survival;Cells;Chemicals;Chronic Obstructive Pulmonary Disease;cigarette smoke;cigarette smoking;Codon Nucleotides;Complex;Complex Mixtures;Cytochrome P450;Data Set;defined contribution;Disease;DNA Damage;Dose;Drug Metabolic Detoxication;Embryo;Environmental Exposure;environmental tobacco smoke;environmental tobacco smoke exposure;Enzymes;epitranscriptome;epitranscriptomics;Etiology;exposed human population;Exposure to;Family;Fibroblasts;Formaldehyde;Future;Gene Expression;Gene Family;Genes;Genetic Models;Goals;Heat shock proteins;Human;In Vitro;Inflammation;Inflammatory;insight;Link;Liver;Lung;Malignant neoplasm of lung;Mammalian Cell;Maps;Mediating;Messenger RNA;Metabolic;Metals;Modeling;Modification;mouse genetics;Mus;Naphthalene;Nose;novel;Organism;Oxidants;oxidation;Pathology;Pathway interactions;Pharmaceutical Preparations;Pharmacologic Substance;Physical condensation;Play;programs;Proteins;Proteome;Proteomics;Rattus;Reporter;response;Ribonucleosides;RNA;Role;selenoprotein;Smoking;Statistical Data Interpretation;Stress;stressor;System;Testing;Therapeutic;Tissues;toxicant;Toxicant exposure;Transcript;Transfer RNA;Translating;Translational Regulation;Translations;Xenobiotics;Yeasts

PROJECT_TITLE: Translational regulation during  cigarette smoking-induced reprogramming of the tRNA epitranscriptome, in vitro and in a mouse smoking model


ADMINISTERING_IC: AI

ARRA_FUNDED: N

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Clinical Research;Genetics;Human Genome;Infectious Diseases;Neurosciences;Pediatric;Primary Immunodeficiencies;Rare Diseases;Sexually Transmitted Infections

ORG_CITY: NEW YORK

ORG_COUNTRY: UNITED STATES

ORG_DEPT: GENETICS

ORG_FIPS: US

ORG_NAME: ROCKEFELLER UNIVERSITY

PHR: Project Narrative We have provided proof-of-principle that HSE in childhood may result from single-gene inborn errors of cortical neuron-intrinsic immunity, with the discovery of TLR3, UNC-93B, TRIF, TRAF3, TBK1, IRF3 and snoRNA31 deficiencies in children with forebrain HSE, and DBR1 deficiency in children with brainstem HSE. We now aim to test the hypothesis that other single-gene inborn errors of neuron-intrinsic immunity to HSV-1 can underlie childhood HSE, and that forebrain and brainstem HSE result from mutations affecting different pathways. We will pursue a GW approach, making use of NGS techniques, including WES, WGS, and RNA-seq, to select candidate variants for validation by biochemical and immunological means.

PI_NAMEs: CASANOVA, JEAN-LAURENT  (contact);ZHANG, SHEN-YING

PROGRAM_OFFICER_NAME: MORRIS FEARS, MARGARET A

PROJECT_TERMS: Acyclovir;Affect;Alleles;Architecture;Biochemical;Brain Stem;Candidate Disease Gene;candidate selection;Cells;Central Nervous System;Child;Childhood;Clinical;clinical care;cohort;Collection;Communicable Diseases;Complication;congenital immunodeficiency;Country;Data;design;Disease;Enrollment;exome sequencing;Family;Fibroblasts;Funding;Genes;Genetic;genetic analysis;Genetic Counseling;Genetic Heterogeneity;genetic linkage analysis;Genetic Predisposition to Disease;Genetic study;genome sequencing;genome-wide;genome-wide linkage;Genotype;Hereditary Disease;Herpes encephalitis;Herpesvirus 1;Heterogeneity;Human Genetics;Immunity;Immunologics;Impairment;Individual;induced pluripotent stem cell;Infection;innovation;Interferon alpha;Interferons;International;IRF3 gene;kindred;Laboratories;Lesion;Leukocytes;Life;Mediating;Mendelian disorder;Minority;Modeling;Molecular;Molecular Diagnosis;Molecular Genetics;mutant;Mutation;Neurologic;Neurons;next generation sequencing;novel;novel therapeutic intervention;Olfactory Nerve;Organ;Parents;Pathogenesis;Pathway interactions;Patients;Penetrance;Phenotype;Physiological;Population;Primary Infection;Privatization;Prosencephalon;rare variant;recruit;Research;Resistance;response;RIPK1 gene;RIPK3 gene;Small Nucleolar RNA;Solid;Survivors;TBK1 gene;Techniques;Testing;TLR3 gene;TNF receptor-associated factor 3;trait;transcriptome sequencing;Trigeminal nerve structure;United States National Institutes of Health;Validation;Variant;Viral Encephalitis;whole genome;Work

PROJECT_TITLE: Inborn errors of immunity in children with herpes simplex encephalitis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IMM-K(52)R]


ADMINISTERING_IC: MH

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Genetics;Human Genome;Mental Health;Mental Illness;Neurosciences;Pediatric

ORG_CITY: NEW HAVEN

ORG_DEPT: NEUROSCIENCES

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: PROJECT NARRATIVE Little is known about how genomic variants affect human brain development, brain function, and neuropsychiatric disorders. We propose a large-scale study to identify DNA variants and their effects on gene expression in brain tissue and single cells from the brain across human brain development. This will provide functional insight into the neurobiological processes responsible for human brain development and function, and disrupted in neuropsychiatric disorders.

PI_NAMEs: SESTAN, NENAD  (contact)

PROGRAM_OFFICER_NAME: PRICE, AMANDA JOY

PROJECT_TERMS: Adolescence;Adult;Affect;Age of Onset;Alleles;Alzheimer's Disease;autism spectrum disorder;Behavior;Biological;Bipolar Disorder;Brain;brain cell;Brain region;brain tissue;Cell Nucleus;cell type;Cells;Chromatin;Code;cohort;Communities;Complement;computerized tools;Copy Number Polymorphism;Corpus striatum structure;Data;data integration;Data Set;Databases;Development;Disease;disorder risk;DNA;epigenetic marker;Epigenetic Process;Etiology;Exhibits;experimental study;fetal;Fetal Development;functional genomics;Gene Expression;Gene Expression Profile;Gene Frequency;Generations;Genes;Genetic;genetic risk factor;genetic variant;genome sequencing;genome wide association study;genomic data;genomic locus;genomic variation;Genotype;histone modification;Human;Human Genome;Individual;insertion/deletion mutation;insight;Link;Methods;Neurobiology;neurodevelopment;Neurodevelopmental Disorder;neuropsychiatric disorder;Neurosciences;next generation;novel;Pattern;postnatal development;Prefrontal Cortex;prenatal;Prevalence;Process;Property;Proteins;Quantitative Trait Loci;rare variant;Regulatory Element;Resources;Risk;risk variant;RNA Splicing;Role;Sampling;Schizophrenia;sex;Single Nucleotide Polymorphism;single nucleus RNA-sequencing;Source;spatiotemporal;Specificity;Spliced Genes;System;Tissues;trait;transcriptome;transcriptome sequencing;transcriptomic profiling;Untranslated RNA;Validation;Variant;whole genome

PROJECT_TITLE: 1/2 Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain development


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Digestive Diseases;Mental Health;Pain Research;Pediatric;Prevention

ORG_CITY: SEATTLE

ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

ORG_STATE: WA

PHR: PROJECT NARRATIVE Chronic pain often clusters in families, where parents and their offspring both experience chronic pain conditions. Young children of parents with irritable bowel syndrome represent an at-risk group for the development of abdominal pain, disability, and excess health care visits in later childhood. Parental solicitous responses to children’s expressions of discomfort and maternal modeling of their own illness behavior contribute to a greater focus on somatic sensations, leading to illness behaviors in children. We hypothesize that an early preventive psychosocial intervention specifically for children at risk for an abdominal pain disorder can alter parental responses and lead to improved child health and decreased health care costs.

PI_NAMEs: LEVY, RONA L.;PALERMO, TONYA M (contact)

PROGRAM_OFFICER_NAME: KING, TRACY

PROJECT_TERMS: Abdomen;Abdominal Pain;Affect;Age;Anatomy;Anxiety;Attention;attentional control;Behavior;Child;Child Health;Child health care;Child Rearing;Childhood;chronic abdominal pain;chronic pain;chronic painful condition;Cognitive Therapy;Cost Savings;Development;Diagnosis;digital platform;disability;early childhood;Education;efficacy evaluation;efficacy testing;emotional distress;Environment;Esthesia;experience;Exposure to;Family;Family health status;follow-up;Future;gastrointestinal symptom;Genetic;Health;Health Care Costs;health care service utilization;Health Care Visit;Health Expenditures;health related quality of life;high risk;improved;Inflammatory;Influentials;interest;intergenerational;Internet;Intervention;Irritable Bowel Syndrome;Link;Mediating;Mental Health;Metabolism;Modeling;Mothers;Neoplastic Processes;Neurobiology;offspring;Online Systems;Outcome;Pain;Pain Disorder;pain symptom;parenting intervention;Parents;Participant;Patient Recruitments;physical conditioning;Populations at Risk;post intervention;preference;prevent;Preventive;preventive intervention;primary outcome;Procedures;protective behavior;protective factors;psychologic;psychosocial;Quality of life;Randomized, Controlled Trials;Reaction;recruit;Recurrent pain;Reporting;Research;Research Design;Resources;response;Risk;Risk Factors;Risk Reduction;Schools;secondary outcome;Severities;Sick Role;social;social learning;social media;Social support;Stress;Symptoms;Technology;Testing;Therapeutic Intervention;transmission process;treatment effect;two-arm study;Work

PROJECT_TITLE: Randomized controlled trial of an internet-based prevention intervention for young children at-risk for functional abdominal pain

STUDY_SECTION: LCBH

STUDY_SECTION_NAME: Lifestyle Change and Behavioral Health Study Section[LCBH]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: LOS ANGELES

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

ORG_STATE: CA

PHR: Relevance to Public Health  Formation of toxic Aβ oligomers is a key pathological process in Alzheimer’s disease. This project aims to study the conversion of oligomers to fibrils, which are less toxic than oligomers. Success of this project may help develop strategies to modulate the oligomer-to-fibril conversion process as a therapeutic intervention.

PI_NAMEs: GUO, ZHEFENG  (contact);PARAVASTU, ANANT KRISHNA

PROGRAM_OFFICER_NAME: YANG, AUSTIN JYAN-YU

PROJECT_TERMS: abeta accumulation;abeta oligomer;Adopted;Aliquot;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease patient;Amyloid beta-42;Amyloid beta-Protein;Amyloid Fibrils;Antibodies;beta pleated sheet;Binding;Brain;Calcium;Cell Nucleus;conformational conversion;Dependence;design;Detergents;Dissociation;Electron Spin Resonance Spectroscopy;Electrons;Event;experimental study;Fluorescence;Goals;Hippocampus;Impairment;In Vitro;Incubated;insight;interest;Isotopes;Kinetics;Label;Laboratories;Lead;Lipid Bilayers;Lipids;Liposomes;Long-Term Potentiation;Measurement;Measures;Mitochondria;Molecular Conformation;Monitor;monomer;Movement;Neurons;Nuclear Magnetic Resonance;Pathogenesis;Pathologic;Pathologic Processes;Phosphorylcholine;Play;Positioning Attribute;presynaptic;Procedures;Process;Proteins;Public Health;Ramp;real time monitoring;Resolution;Role;Sampling;Signal Transduction;Slice;solid state nuclear magnetic resonance;Stains;Structure;success;Synapses;System;tau Proteins;Temperature;Testing;Therapeutic Intervention;Time;Transgenic Mice;Transmission Electron Microscopy;Vesicle;Water;Width

PROJECT_TITLE: Combining electron and nuclear magnetic resonance to track Alzheimer's amyloid-beta oligomer-to-fibril conversion

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: INDIANAPOLIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: INDIANA UNIVERSITY INDIANAPOLIS

ORG_STATE: IN

PHR: Narrative Multiple myeloma (MM) is a neoplasm of bone marrow resident plasma cells that remains incurable, primarily due to the development of pro-MM survival responses. We have found that the PIM2 kinase plays an important role in MM survival, and inhibiting it leads to MM cell death even in the presence in major pro-MM survival signals. The work proposed will define the molecular mechanisms underlying PIM2’s pro-survival effects, which will point to novel therapeutic strategies for multiple myeloma. 1

PI_NAMEs: LEE, KELVIN P. (contact);OLEJNICZAK, SCOTT HENRY

PROGRAM_OFFICER_NAME: HOWCROFT, THOMAS K

PROJECT_TERMS: Acute Myelocytic Leukemia;Affect;American Cancer Society;Binding;Binding Proteins;Biological;Biological Assay;Bone Marrow;Bone Marrow Neoplasms;c-myc Genes;Cell Death;Cell Survival;Cells;Cessation of life;chemotherapeutic agent;Code;Complex;constitutive expression;curative treatments;Data;Development;Disease Progression;Down-Regulation;experimental study;Family;fatty acid oxidation;Gene Expression;Genes;Genetic Transcription;Hematologic Neoplasms;Homeostasis;inhibitor;kinase inhibitor;knock-down;Malignant Neoplasms;Messenger RNA;Metabolism;Mitochondria;mitochondrial metabolism;Modeling;Molecular;Multiple Myeloma;mutant;nanomolar;new therapeutic target;Non-Hodgkin's Lymphoma;novel;novel therapeutic intervention;novel therapeutics;Oncogenes;Oncogenic;overexpression;Pathogenesis;Patients;Phosphotransferases;PIM1 gene;Plasma Cells;Play;Production;programs;Proliferating;promoter;protein expression;Protein-Serine-Threonine Kinases;Proteins;proto-oncogene protein pim;Reactive Oxygen Species;Regulation;Regulatory Element;Reporting;Resistance;Respiration;response;Role;Serine;Signal Transduction;Small Interfering RNA;Solid;Solid Neoplasm;Source;Stimulus;Testing;therapeutic target;therapy resistant;Transactivation;Treatment Failure;Up-Regulation;Work

PROJECT_TITLE: Novel pro-survival mechanisms of PIM2 in multiple myeloma

STUDY_SECTION: BCO

STUDY_SECTION_NAME: Biochemical and Cellular Oncogenesis Study Section[BCO]


NIH_SPENDING_CATS: Biomedical Imaging;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Clinical Trials and Supportive Activities;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Precision Medicine;Women's Health Research

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Narrative Clinical care of metastatic breast cancer demands rigorous monitoring to ensure that a patient is on the right treatment at the right time. Our proposal seeks to validate and demonstrate the clinical utility of a CLIA- compliant low-cost, rapid response monitoring strategy for circulating tumor DNA (ctDNA) using customized digital droplet PCR (ddPCR) and next generation sequencing (NGS). This hybrid approach to molecular surveillance will significantly improve the management of metastatic breast cancer by anticipating response or progression sooner than existing clinical standard of care.

PI_NAMEs: MILES, GEORGE  (contact)

PROGRAM_OFFICER_NAME: OSSANDON, MIGUEL

PROJECT_TERMS: Address;advanced breast cancer;advanced disease;Adverse reactions;Allergic Reaction;Automobile Driving;Benchmarking;Biological;Biological Assay;Biological Markers;Blood;blood-based biomarker;bone;bone imaging;Breast Cancer Patient;burden of illness;Cancer Etiology;Cancer Patient;cancer therapy;Cells;Cessation of life;circulating DNA;CLIA certified;Clinical;clinical care;Clinical Management;clinical trial enrollment;Clinical Trials;Collection;computer framework;cost;cost effectiveness;Cost Savings;Coupled;Data;design;Detection;Diagnosis;digital;digital measure;Disease;Disease Progression;Distant;DNA sequencing;Dose;Drug Costs;effective therapy;efficacy evaluation;Evaluation;experience;Exposure to;Flare;Funding;Genomics;Half-Life;health inequalities;high risk;Hybrids;Hypersensitivity;Image;imaging modality;Immunotherapy;improved;ineffective therapies;Institution;Intervention;Investigation;Kidney Diseases;Laboratories;Lead;liquid biopsy;Malignant Breast Neoplasm;Malignant Neoplasms;Metastatic breast cancer;Methods;minimally invasive;Molecular;molecular dynamics;Monitor;Multicenter Trials;Mutation;Mutation Detection;Neuropathy;new therapeutic target;next generation sequencing;Oncology;Organ;Patients;performance tests;Peritoneum;Pharmaceutical Preparations;Plasma;Positron-Emission Tomography;Precision therapeutics;predictive marker;Primary Neoplasm;procedure cost;Process;prognostication;prospective;Prospective Studies;Proteins;Quality Control;Quality of life;radiological imaging;Radiology Specialty;Randomized;Reporting;response;Risk;Sampling;Scanning;side effect;Site;Staging;standard of care;Systemic Therapy;targeted treatment;Testing;Time;Toxic effect;treatment response;trend;tumor;Tumor Biology;tumor DNA;Tumor Markers;Tumor Promotion;Tumor-Infiltrating Lymphocytes;Underserved Population;Variant;X-Ray Computed Tomography

PROJECT_TITLE: Rapid Response Monitoring with Circulating Tumor DNA in Metastatic Breast Cancer


ADMINISTERING_IC: HL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Biomedical Imaging;Cancer;Chronic Obstructive Pulmonary Disease;Lung;Lung Cancer;Patient Safety;Prevention

ORG_CITY: BOSTON

ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

ORG_STATE: MA

PHR: Acute exacerbations of Chronic Obstructive Pulmonary Disease (COPD) are associated with accelerated lung function decline, impaired health status, increased hospitalization, and increased mortality. Population heterogeneity of those at risk for these events makes it difficult to identify subgroups that are particularly susceptible. In carrying out the research outlined in the following proposal, we will perform extensive quantitative-CT image characterization of study subjects, and we will apply Bayesian trajectory analysis on these measures to better identify subpopulations with differing innate susceptibility to exacerbations.

PI_NAMEs: ROSS, JAMES  (contact)

PROGRAM_OFFICER_NAME: SHENOY, SIDDHARTH KAUP

PROJECT_TERMS: Acceleration;Acute;acute symptom;adverse event risk;adverse outcome;Age;Aging;Algorithms;Biological Markers;Blood Vessels;Cardiac;Cardiopulmonary;Chronic Obstructive Pulmonary Disease;Clinical;cohort;Collection;Complex;computed tomography screening;cost;Data;Data Sources;Dimensions;Disease;disease heterogeneity;Disease Progression;Early Diagnosis;Early identification;Event;Future;Genetic;Genetic Predisposition to Disease;Goals;Health;Health Status;Heterogeneity;Hospitalization;Image;imaging biomarker;Impaired health;Impairment;improved;Individual;innovation;Intercept;Learning;Lung;lung cancer screening;Malignant neoplasm of lung;Measures;Modeling;Morphology;mortality;Nature;novel;Outcome;Pathologic;Patients;Pattern;Persons;Phenotype;Population;Population Heterogeneity;Populations at Risk;Predisposition;preempt;prevent;Pulmonary Emphysema;pulmonary function;pulmonary function decline;quantitative imaging;Radiology Specialty;Research;response;Risk;risk stratification;Scanning;Severity of illness;skeletal muscle wasting;Smoke;Smoker;Staging;Structural defect;Study Subject;Subgroup;Syndrome;System;Testing;tool;Training;Work;X-Ray Computed Tomography

PROJECT_TITLE: Risk Stratification for COPD Exacerbations with CT Analysis and Multidimensional Trajectory Subtyping

STUDY_SECTION: CTIS

STUDY_SECTION_NAME: Clinical Translational Imaging Science Study Section[CTIS]


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Pediatric;Regenerative Medicine

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE The proposed research is relevant to public health as it focuses on fundamental aspects of vertebrate devel- opment—including cell-type diversiﬁcation, self-organizing interactions and positional information—that have implications for normal patterning and homeostasis, genetic disease and birth defects, and the goals of replac- ing or repairing lost tissue through regenerative medicine. 1

PI_NAMEs: PARICHY, DAVID M (contact)

PROGRAM_OFFICER_NAME: WELLS, MELISSA LYNN

PROJECT_TERMS: Adult;Aging;Animals;Behavioral Assay;cell behavior;cell type;Cells;Comparative Biology;Congenital Abnormality;craniofacial;Defect;Development;Distant;Elements;Embryo;Embryonic Development;Environment;experimental study;Genes;Genetic;genetic analysis;Genetic Diseases;Genomics;Goals;high resolution imaging;Homeostasis;Human Genetics;Inherited;insight;Location;Maintenance;Malignant Neoplasms;Melanoma;Morphology;Mutation Analysis;Neural Crest;Neural Crest Cell;novel;Organ;Outcome;Pathology;Pattern;Pattern Formation;Peripheral Nervous System;permissiveness;Phenotype;Pigmentation physiologic function;Pigments;Postembryonic;postembryonic stem cell;programs;Public Health;Regenerative Medicine;repaired;Research;Role;self organization;Skeleton;Skin;stem cell fate specification;stem cells;Stereotyping;teleost fish;Time;Tissues;trait;Translating;two-dimensional;Variant;Vertebrates;Work;Zebrafish

PROJECT_TITLE: Developmental origins and homeostatic mechanisms underlying adult phenotypes

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;Clinical Trials and Supportive Activities;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Patient Safety;Skin Cancer

ORG_CITY: ROCHESTER

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: Project Narrative This proposal investigates the use of two photon fluorescence microscopy as tool to evaluate biopsies and surgical margins of nonmelanoma skin cancer. New technology will be developed that accelerates imaging speeds and reduces the cost of treatment. Clinical studies are proposed that will investigate both real-time diagnosis of biopsies and the evaluation of surgical margins using two photon fluorescence microscopy in a dermatology clinic.

PI_NAMEs: GIACOMELLI, MICHAEL GENE (contact)

PROGRAM_OFFICER_NAME: AVULA, LEELA RANI

PROJECT_TERMS: Acceleration;Address;Anesthesia procedures;Basal cell carcinoma;Biopsy;Biopsy Specimen;Cancer Patient;cancer surgery;cancer type;Caring;Clinic;Clinic Visits;Clinical;Clinical Research;Clinical Trials;Collaborations;common treatment;Conduct Clinical Trials;Consent;Consumption;contrast enhanced;Conventional Surgery;cost;cost effective;Dermatologic;Dermatology;Detection;detector;Development;Diagnosis;Diagnostic;Diagnostic Procedure;Dyes;Evaluation;Excision;experience;Fiber;Fluorescence Microscopy;Frozen Sections;Goals;Health Care Costs;Health Services Accessibility;Healthcare Systems;high risk;Histologic;histological image;Histology;Histopathology;human tissue;Image;image guided;Image-Guided Surgery;Imaging technology;improved;Individual;instrument;Label;Lasers;Malignant Neoplasms;Medicare;Methods;microscopic imaging;Microtomy;miniaturize;Mohs Surgery;Molecular;Morbidity - disease rate;multidisciplinary;new technology;Operative Surgical Procedures;Outcome;Paraffin;Patient Schedules;Patients;photomultiplier;Photons;Postoperative Period;Prevalence;Procedures;Process;programs;Protocols documentation;recruit;Recurrence;Recurrent tumor;Research;Resources;Risk;rural area;Sensitivity and Specificity;Silicon;skin biopsy;Skin Cancer;Skin Carcinoma;Slide;Source;Speed;Squamous cell carcinoma;Stains;standard of care;Surgical Management;Surgical margins;Surgical Pathology;surgical risk;System;Technology;Testing;Time;Tissues;tool;Treatment Cost;tumor;two-photon;Variant;Visit

PROJECT_TITLE: Two photon fluorescence microscopy for dermatologic surgery and biopsy

STUDY_SECTION: IGIS

STUDY_SECTION_NAME: Imaging Guided Interventions and Surgery Study Section[IGIS]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Diabetes;Genetics;Nutrition;Obesity;Pediatric;Rare Diseases

ORG_CITY: STANFORD

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: STANFORD UNIVERSITY

PHR: Project Narrative This project seeks to understand a fundamental mechanism controlling feeding and obesity in humans, which is organized in part by the primary cilium, an ancient signaling organelle in the cell. Using human genetics, proteomics and quantitative cell biology, we have found that genes encoding proteins within the cilium are mutated in rare inherited syndromes, but more recently found 1000s of cilia-linked mutations in humans with obesity or high Body Mass Index (BMI) causing signaling molecular defects, which we will study here. By examining new genes and signaling mechanisms, we endeavor to explain and quantify the effects of cilia-related obesity lesions in patients, to identify new targets for treating obesity and metabolic disease, and to facilitate patient diagnosis and selection for molecularly rationale therapies and precise therapeutic choices.

PI_NAMEs: JACKSON, PETER KENT (contact)

PROGRAM_OFFICER_NAME: AINSZTEIN, ALEXANDRA M

PROJECT_TERMS: 26S proteasome;Adipocytes;Affect;Affinity Chromatography;appendage;Automobile Driving;Bardet-Biedl Syndrome;base;Binding;Binding Proteins;Biological;Cell Culture Techniques;Cells;Cellular biology;Centrioles;Centrosome;Cilia;ciliopathy;Clinical Research;Clustered Regularly Interspaced Short Palindromic Repeats;Communication;Complex;Coupling;Data;Defect;developmental disease;Diabetes Mellitus;Diagnosis;dietary;Disease;Distal;Docking;druggable target;Embryo;Endocrine;Endosomes;Excision;extracellular;Feedback;feeding;FREQ gene;G Protein-Coupled Receptor Signaling;G-Protein-Coupled Receptors;Generations;Genes;Genetic;genetic pedigree;Genetic Transcription;genome wide association study;Glucagon;Goals;Health;high body mass index;Hormone Receptor;Hormone secretion;Human;Human Genetics;improved;Inherited;insulin secretion;Islet Cell;Islets of Langerhans;Knockout Mice;Laboratories;Lesion;Ligands;Link;lipid biosynthesis;Malignant Neoplasms;Manuscripts;Mass Spectrum Analysis;Measures;Mediating;Membrane;Metabolic Diseases;Microtubules;Modeling;Molecular;Molecular Genetics;Molecular Profiling;Mothers;multicatalytic endopeptidase complex;Mutate;Mutation;myristoylation;novel;Obesity;obesity genetics;Organelles;Pancreatic Polypeptide;Pathogenesis;Pathology;Pathway interactions;Patient Selection;Patients;Phenotype;phosphoproteomics;Phosphotransferases;Physiological;Play;Population;Predisposition;Preparation;Process;profiles in patients;protein degradation;protein function;Proteins;Proteomics;rare condition;receptor;recruit;Recycling;Regulation;response;Role;Satiation;scaffold;screening;Selection for Treatments;Sensory;Signal Pathway;Signal Transduction;Site;Situs Inversus;Structure;Surveys;Syndrome;tau-protein kinase;tau-tubulin kinase;Technology;Testing;Therapeutic;tissue regeneration;Tissues;trafficking;Vesicle;Work

PROJECT_TITLE: Mechanisms of Ciliary Signaling Controlling Obesity and Metabolic Disease

STUDY_SECTION: NCSD

STUDY_SECTION_NAME: Nuclear and Cytoplasmic Structure/Function and Dynamics Study Section[NCSD]


NIH_SPENDING_CATS: Biotechnology;Brain Cancer;Brain Disorders;Cancer;Genetics;Neurosciences;Rare Diseases;Stem Cell Research;Stem Cell Research - Embryonic - Human

ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: PROJECT NARRATIVE Glioblastoma is the most common primary malignant central nervous system tumor that is almost always fatal within 2 years of diagnosis. This project will investigate the regulation of GBM cells by human GABAergic neurons using advanced neuroscience techniques. The proposed research is relevant to public health because it will advance our understanding of brain tumor pathophysiology.

PI_NAMEs: SHCHEGLOVITOV, OLEKSANDR  (contact)

PROGRAM_OFFICER_NAME: WOODHOUSE, ELIZABETH

PROJECT_TERMS: Adult;Affect;Brain;Brain Neoplasms;cancer cell;Cell Adhesion Molecules;Cell Communication;Cell Proliferation;Cell Survival;cell type;Cells;Central Nervous System;Chemical Synapse;Chemicals;Child;Chimera organism;Clinical Trials;Coculture Techniques;Communication;Diagnosis;effective therapy;Electrophysiology (science);Environment;Ethics;excitatory neuron;Excitatory Synapse;Exhibits;experimental study;Functional disorder;Future;GABA Receptor;gamma-Aminobutyric Acid;Gene Expression Profile;Glioblastoma;Glioma;Glutamates;Goals;Growth;Growth Factor;Human;human induced pluripotent stem cells;human stem cell-derived;improved;in vivo;Individual;induced pluripotent stem cell;innovation;insight;Malignant neoplasm of central nervous system;Measures;Mediating;Membrane Potentials;Molecular;mortality;Mus;neoplastic cell;nerve stem cell;neuroligin 1;neuroligin 3;Neurons;neuroregulation;Neurosciences;new therapeutic target;Normal Cell;novel;optogenetics;Organoids;patch clamp;Pathogenesis;Pathology;Patients;pediatric patients;Pharmacology;postsynaptic;presynaptic neurons;Primary Brain Neoplasms;Proliferating;Property;Public Health;rabies viral tracing;Regulation;Research;response;Role;Signal Transduction;Signaling Protein;single-cell RNA sequencing;Slice;Specificity;spheroids;stem cells;Synapses;System;Techniques;Testing;therapeutic target;tool;tumor;tumor growth;Tumor Promotion;Tumor Tissue;Work

PROJECT_TITLE: Regulation of glioblastoma cells by GABAergic neurons in human organoid-tumor chimeras

STUDY_SECTION: CNBT

STUDY_SECTION_NAME: Clinical Neuroimmunology and Brain Tumors Study Section[CNBT]


ADMINISTERING_IC: TW

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Clinical Research;Hematology;Infectious Diseases;Malaria;Rare Diseases;Vector-Borne Diseases

ORG_CITY: ALBUQUERQUE

ORG_NAME: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR

ORG_STATE: NM

PHR: PROJECT NARRATIVE To meet the current and future challenges created by the leading infectious diseases in Kenya (e.g., malaria and COVID-19), we propose continuation of our research training program that has been continuously funded since being established in 2002. To maximize programmatic impact for training the next generation of Kenyan leaders, we have assembled a world-class team of multidisciplinary investigators from Kenya and Ghana who were former trainees in the program, along with long-standing partners at the University of New Mexico and Los Alamos National Laboratory. We propose advanced training in state-of-the art methodologies under the rubric of thematic target areas (Host-Pathogen Dynamics, Therapeutic Discovery, and Disease Modeling), strategically selected for maximizing long-term capacity building to combat high-burden infectious diseases in Kenya. ,

PI_NAMEs: OUMA, COLLINS ;PERKINS, DOUGLAS JAY (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Address;African;Area;Award;career development;Categories;Cellular biology;Childhood;combat;Communicable Diseases;Competence;COVID-19;Data Analytics;disease model;doctoral student;Faculty;Fostering;Funding;Future;Ghana;Grant;Institution;Instruction;International;international partnership;Kenya;Knowledge;Laboratories;Malaria;malarial anemia;Manuscripts;Medical Research;meetings;Mentors;Methodology;multidisciplinary;New Mexico;pathogen;Peer Review;Phase;Postdoctoral Fellow;programs;Public Health;Research;Research Institute;Research Methodology;Research Personnel;Research Training;Science;Scientific Advances and Accomplishments;Scientist;skills;Societies;Technology;Technology Transfer;Therapeutic;Training;Training Programs;Universities

PROJECT_TITLE: Training and Research on Severe Malarial Anemia

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-AIDC-Z(55)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Nanotechnology;Orphan Drug;Radiation Oncology;Rare Diseases

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: PROJECT NARRATIVE. The overall 5-year survival rate for head and neck cancer has not improved much over the last few decades with both conventional multimodal treatment and emerging immunotherapies known to have an adverse (and sometimes fatal) impact on quality of life. The goal of this proposal is to investigate the mechanisms driving the effectiveness of a novel immunotherapy for head and neck cancer we call “SynerGel” and determine how it can be used in combination with standard-of-care radiation therapy to reduce treatment toxicity. By doing so, we aim to enhance our understanding of how both tumor and immune cells in the tumor environment can be manipulated to produce a strong anti-tumor effect while reducing the side effects of treatment.

PI_NAMEs: YOUNG, SIMON  (contact)

PROGRAM_OFFICER_NAME: CHEN, ZHONG

PROJECT_TERMS: Activities of Daily Living;Acute;Address;antitumor effect;Automobile Driving;Biocompatible Materials;cancer immunotherapy;cancer type;Cells;chemotherapy;Combination immunotherapy;Combined Modality Therapy;cytokine;cytotoxic;Data;Dendritic Cells;design;Dose;effective therapy;Effectiveness;Effector Cell;Environment;exhaustion;FDA approved;Generations;Goals;Head and Neck Cancer;Hydrogels;Immune;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;immune-related adverse events;Immunity;Immunologic Adjuvants;Immunologic Stimulation;Immunologics;Immunomodulators;immunomodulatory therapies;Immunophenotyping;immunoregulation;Immunotherapeutic agent;Immunotherapy;improved;In Situ;Inflammatory Response;Injectable;Injections;insight;Interferons;Lymphocyte;malignant mouth neoplasm;Malignant Neoplasms;Mediating;Molecular;Myeloid Cells;Myeloid-derived suppressor cells;nanofiber;Nature;next generation;NOS2A gene;novel;novel therapeutic intervention;Pathway interactions;Patients;Peptides;Pharmaceutical Preparations;Pre-Clinical Model;Predisposition;Quality of life;Radiation therapy;rational design;recruit;Refractory;Regulatory T-Lymphocyte;Resistance;response;Risk;self assembly;Severities;Signal Transduction;Solid Neoplasm;spatiotemporal;standard of care;Survival Rate;System;systemic toxicity;T cell response;T memory cell;T-Lymphocyte;Technology;Tertiary Protein Structure;Testing;Toxic effect;Treatment Side Effects;Treatment-related toxicity;tumor;tumor heterogeneity;tumor microenvironment;tumor-immune system interactions

PROJECT_TITLE: SynerGel: A Novel Tumor Microenvironment-Modulating Hydrogel for Local Immunotherapy

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-OTC-M(08)F]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Dissemination and Implementation Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Maternal Health;Opioid Misuse and Addiction;Opioids;Prevention;Substance Misuse;Women's Health Research

ORG_CITY: Pittsburgh

ORG_NAME: MAGEE-WOMEN'S RES INST AND FOUNDATION

ORG_STATE: PA

PHR: The rate of unintended pregnancy among women with substance use disorders (SUDs) is twice that of the general population and is perpetuated by low rates of contraceptive use, especially in the postpartum period. This research will determine the effect of a novel, patient-centered, reproductive planning decision support tool called MyPath on postpartum contraceptive utilization and reproductive health outcomes (i.e. unintended pregnancy, short interpregnancy interval) among women with SUDs. Findings from this research will provide high-quality evidence about how to improve postpartum contraceptive decision-making for women with SUDs and if successful, will identify a low-cost scalable solution that can be implemented in most clinical settings.

PI_NAMEs: KRANS, ELIZABETH E (contact)

PROGRAM_OFFICER_NAME: HIGHSMITH, KEISHER S

PROJECT_TERMS: 2 arm randomized control trial;Address;Birth;Characteristics;Child;child bearing;Clinical;clinical care;clinical practice;Conceptions;condoms;Conflict (Psychology);Contraceptive Agents;Contraceptive methods;Contraceptive Usage;cost;Counseling;Data;Decision Making;design;Discipline of obstetrics;Effectiveness;effectiveness-implementation RCT;Evaluation;Failure;Family Planning;Fertility;future implementation;General Population;Goals;Health;health care availability;health inequalities;Health system;Hybrids;illicit drug use;improved;Interview;Knowledge;Learning;Maternity Hospitals;Measures;Mediating;Medicaid eligibility;Methods;Motivation;novel;Observational Study;opioid use disorder;Outcome;patient oriented;Patients;postpartum contraception;Postpartum Period;Postpartum Women;preference;Pregnancy;pregnant;pressure;process evaluation;Provider;Randomized, Controlled Trials;reproductive;reproductive coercion;Reproductive Health;Research;Research Design;Science;sex;sexually active;side effect;Substance Use Disorder;support tools;Testing;Thinking;Translations;treatment as usual;unintended pregnancy;Woman;women's outcomes;Work

PROJECT_TITLE: Improving Postpartum Contraceptive Decision-Making Among Women With Substance Use Disorders

STUDY_SECTION: CMPC

STUDY_SECTION_NAME: Clinical Management of Patients in Community-based Settings Study Section[CMPC]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Genetics;Immunotherapy;Orphan Drug;Rare Diseases

PHR: Public Health Relevance Statement Our application is to determine how targeting the histone demethylase KDM4A inhibits HNSCC cell invasion and activates tumor cell-intrinsic immune responses by inducing DNA replication stress and determine whether targeting KDM4A can help to overcome HNSCC resistance to PD-1 blockade therapy. The discoveries from this study will have important implications in developing novel therapeutic strategies for treating human neck and neck cancer.

PI_NAMEs: WANG, CUN-YU  (contact)

PROJECT_TERMS: Ablation;Adjuvant;anti-PD1 therapy;cancer cell;cancer immunotherapy;CD8-Positive T-Lymphocytes;cell motility;Cells;chemokine;chemoradiation;Chromatin;Colorectal Cancer;cytotoxic;Development;DNA biosynthesis;DNA Damage;DNA replication fork;DNA Replication Induction;effective therapy;Epigenetic Process;Epithelium;Excision;Exhibits;Gene Activation;Gene Expression;Genes;Genetic Transcription;Genomics;Growth;Head and Neck Cancer;Head and Neck Squamous Cell Carcinoma;Head and neck structure;histone demethylase;histone methylation;HPV negative;Human;Immune;immune checkpoint;immune checkpoint blockade;Immune checkpoint inhibitor;Immune response;Immunity;immunogenicity;Impairment;improved;Infiltration;Interferon Type I;Invaded;Knockout Mice;lymph nodes;Malignant Breast Neoplasm;Malignant Neoplasms;Melanoma;Mesenchymal;Metastatic Neoplasm to Lymph Nodes;Molecular;mouse model;Mutation;Neck;Neck Cancer;Neoplasm Metastasis;neoplastic cell;Nitroquinolines;novel;novel therapeutic intervention;novel therapeutics;objective response rate;Operative Surgical Procedures;Oral cavity;Oropharyngeal;Oxides;Patients;PD-1 blockade;PD-1/PD-L1;pharmacologic;Play;pressure;Probability;Production;public health relevance;recruit;Recurrence;replication stress;Resistance;Role;S phase;Solid Neoplasm;standard care;success;Survival Rate;T cell infiltration;T-Lymphocyte;Testing;Tissues;Transcriptional Activation;transcriptome sequencing;tumor;Tumor Cell Invasion;Tumor Immunity;Tumor Promotion;tumor-immune system interactions;Work

PROJECT_TITLE: The Inhibition of HNSCC Growth and Metastasis by Targeting KDM4A


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Comparative Effectiveness Research;Drug Abuse (NIDA only);Health Services;Opioid Misuse and Addiction;Opioids;Physical Injury - Accidents and Adverse Effects;Substance Misuse

ORG_NAME: BOSTON MEDICAL CENTER

PHR: PROJECT NARRATIVE Although opioid overdose deaths are persistently high, increasing availability of effective medications for opioid use disorder (MOUD) are one reason for optimism. We propose to use the novel Massachusetts Public Health Data warehouse to compare the effect of different buprenorphine and naltrexone formulations on retention and fatal and nonfatal opioid overdose after opioid detoxification. We will utilize an emulated trials approach with advanced statistical techniques to improve causal inference and will compare results directly with the X:BOT randomized controlled trial of sublingual buprenorphine-naloxone and extended-release naltrexone. The findings of these comparative effectiveness analyses will inform policy and practice on the coverage and use of an expanding array of MOUD formulations.

PI_NAMEs: LAROCHELLE, MARC  (contact)

PROGRAM_OFFICER_NAME: SU, SHELLEY

PROJECT_TERMS: active method;addiction;Buprenorphine;buprenorphine treatment;common treatment;comparative effectiveness;comparative effectiveness analysis;Comparative Effectiveness Research;comparative effectiveness study;comparative effectiveness trial;compare effectiveness;contingency management;craving;Data;Data Set;Data Sources;data warehouse;Databases;Fatality rate;FDA approved;Formulation;Half-Life;Health Services Research;high risk;illicit opioid;improved;improved outcome;Incentives;Individual;Injectable;Intervention;Link;Massachusetts;Mediator;Medical;medication for opioid use disorder;Medicine;Morbidity - disease rate;mortality;Naltrexone;novel;Observational Study;Opioid;opioid mortality;opioid overdose;opioid use;opioid withdrawal;optimism;Outcome;Outpatients;Participant;Patient Selection;Patients;Policies;Population;Pragmatic clinical trial;Probability;Protocols documentation;Public Health;randomized, clinical trials;Randomized, Controlled Trials;retention rate;Risk;standard of care;stem;Structural Models;Suboxone;Techniques;Time;treatment comparison;trial comparing;uptake;Work

PROJECT_TITLE: MOUD Comparative Effectiveness Study

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


ORG_CITY: GALVESTON

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: UNIVERSITY OF TEXAS MED BR GALVESTON

PHR: Project Narrative Arterial thrombosis, which describes the formation of abnormal blood clots in the artery, is a highly fatal disease that leads to stroke and myocardial infarction. Current therapeutic strategies for arterial thrombosis have relatively low effectiveness and a major risk of excessive bleeding. By identifying biomechanical platelet aggregation as a key player in arterial thrombosis, this proposal aims to establish a mechanism-driven approach to selectively inhibit biomechanical platelet aggregation without compromising hemostasis, which will lay the foundation for the development of therapeutics to better prevent and treat arterial thrombosis.

PI_NAMEs: CHEN, YUNFENG  (contact)

PROGRAM_OFFICER_NAME: HILL-PRYOR, CRYSTAL DARLEANE-ROBIN

PROJECT_TERMS: Adhesions;Affect;American;Antibodies;Arteries;Award;Binding;Biochemical;Biological Assay;Biology;Biomechanics;Biomedical Engineering;Blood coagulation;Blood coagulation tests;Blood flow;Blood Platelets;Blood Vessels;candidate identification;candidate selection;career;career development;Clinical Treatment;Collaborations;crosslink;Data;design;Diabetes Mellitus;diabetic patient;Disease;Effectiveness;Evaluation;Fibrinolytic Agents;Foundations;Glycoproteins;Goals;Hematology;Hemorrhage;Hemostatic function;Hot Spot;In Vitro;in vivo;Incidence;inhibitor;Integrins;mechanical force;mechanotransduction;Mediating;Mentors;Microfluidics;Modeling;Molecular;Monoclonal Antibodies;Morbidity - disease rate;mortality;Mus;mutant;Mutation;Myocardial Infarction;Names;Pathologic;Performance;Phase;Plasma Proteins;Platelet aggregation;Platelet Aggregation Inhibition;Postdoctoral Fellow;pre-clinical;prevent;Program Development;Property;prototype;receptor;Research;Research Personnel;Risk;Safety;screening;Screening procedure;shear stress;Stenosis;Stroke;System;Testing;Therapeutic;therapeutic development;thrombogenesis;Thrombosis;thrombotic;translational approach;von Willebrand Factor;Work

PROJECT_TITLE: Inhibiting biomechanical platelet aggregation to prevent arterial thrombosis without compromising hemostasis

STUDY_SECTION: NSS

STUDY_SECTION_NAME: NSS


NIH_SPENDING_CATS: Cancer;Clinical Research;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Hematology;Orphan Drug;Precision Medicine;Rare Diseases;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Transplantation

ORG_NAME: FRED HUTCHINSON CANCER CENTER

PHR: Project Narrative We will study how immune system genes affect the success of transplantation for patients of diverse ancestries. This information will help to lower risks through individualized treatment options for future patients.

PI_NAMEs: PETERSDORF, EFFIE W (contact)

PROGRAM_OFFICER_NAME: KULKARNI, SHILPA S

PROJECT_TERMS: Acute Graft Versus Host Disease;Acute leukemia;Affect;Affinity;African;African ancestry;Alleles;Artificial Intelligence;Asian ancestry;Binding;Biology;Caucasians;Clinical;clinical care;Clinical Data;clinical decision-making;clinical practice;Clinical Trials;Cord Blood Hematopoietic stem cells;Cord Blood Stem Cell Transplantation;Counseling;Data;Data Files;design;Dimensions;disorder risk;Disparity;Donor person;Ensure;ethnic diversity;Failure;Frequencies;Funding;Future;GEM gene;gene function;Genes;Genetic Polymorphism;Genotype;Germ Lines;Goals;graft vs host disease;Haplotypes;Health;Hematological Disease;Hematopoietic Stem Cell Transplantation;high risk;Hispanic ancestry;Histocompatibility;HLA G antigen;HLA-A gene;HLA-B Antigens;HLA-C Antigens;HLA-DP Antigens;HLA-DPB1 gene;Immune system;improved outcome;Individual;individual patient;individualized medicine;International;Knowledge;leukemia;leukemia relapse;Life;Ligands;Linkage Disequilibrium;Malignant Neoplasms;Measures;Methods;mortality;Natural Killer Cells;Nature;novel;Outcome;outcome disparities;Patients;Peptide Leader Sequences;Peptides;permissiveness;personalized medicine;personalized strategies;Phenotype;Population;Population Group;prognostication;Property;protein function;receptor;Recurrent disease;Regimen;Registries;Relapse;Reproducibility;Research;Resolution;Risk;Role;Safety;Selection Criteria;Sentinel;Shapes;success;Survival Rate;survivorship;Testing;tool;Translating;Transplant Recipients;Transplantation;tumor;Umbilical Cord Blood;Umbilical Cord Blood Transplantation;Validation;Variant;Work;working group

PROJECT_TITLE: Hematopoietic Stem Cell And Cord Blood Transplantation


FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

NIH_SPENDING_CATS: Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: ORTHOPEDICS

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: This proposal focuses on research and training in the fields of developmental and stem cell biology, as well as their potential applications in the up-and-coming field of regenerative medicine. A unique component of the training program is exposure of this next generation of scientists to the clinical correlates of the foundational research problems they are investigating. These young researchers will be at the forefront of translating emerging research into the control of developmental cell fate towards new stem-cell-based approaches for healing the human body.

PI_NAMEs: CRUMP, GAGE D (contact)

PROGRAM_OFFICER_NAME: MUKHOPADHYAY, MAHUA

PROJECT_TERMS: Developmental Biology;Natural regeneration;stem cells;Training

PROJECT_TITLE: Training in Developmental Biology, Stem Cells and Regeneration


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Autoimmune Disease;Diabetes;Genetics

ORG_CITY: ANN ARBOR

ORG_DEPT: PHARMACOLOGY

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Diabetes is a costly and pervasive disease that affects more than 10.5% of the US population and represented the 7th leading cause of death in 2019. This disease results from pancreatic β cell dysfunction and death preventing normal insulin levels required to maintain proper blood- glucose homeostasis. Here, I propose to better define the molecular mechanisms by which retinoic acid signaling synergizes with GATA transcription factors to regulate β cell development and function to improve therapeutic treatment of diabetes.

PI_NAMEs: LORBERBAUM, DAVID  (contact)

PROGRAM_OFFICER_NAME: HWA, ALBERT J

PROJECT_TERMS: Address;Adult;Advisory Committees;Affect;Beta Cell;beta cell replacement;Blood Glucose;blood glucose regulation;Cause of Death;Cell Differentiation process;Cell Physiology;cell replacement therapy;Cells;Cessation of life;cofactor;cost;cost estimate;Data;Defect;Development;diabetes management;Diabetes Mellitus;differentiation protocol;Disease;DNA;Embryo;Endocrine;endocrine pancreas development;Engineering;Enzymes;Epitopes;Excision;Follow-Up Studies;Functional disorder;GATA6 transcription factor;Genes;genetic analysis;Genetic Transcription;Human;human pluripotent stem cell;improved;In Vitro;in vivo;in vivo Model;Individual;innovation;Insulin;islet;Islet Cell;Islets of Langerhans;Knowledge;Literature;Maintenance;Mediating;Mediator;Minor;Modeling;Molecular;mouse model;Mus;novel;Pancreas;pancreas development;pancreatic islet function;Pathway interactions;Patients;Persons;Phenotype;Physiological;Pilot Projects;Play;Population;prevent;Process;progenitor;Protocols documentation;Regulatory Pathway;Replacement Therapy;Reporting;Repression;Research;Role;Signal Transduction;Specific qualifier value;stem cell fate specification;Structure of beta Cell of islet;synergism;Testing;Therapeutic;Therapeutic Intervention;tool;transcription factor;Transplantation;Tretinoin;type I and type II diabetes;United States;WNT Signaling Pathway;Work

PROJECT_TITLE: Cell signaling and transcription factors in pancreatic islet development and function


NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Social Determinants of Health

ORG_CITY: MILWAUKEE

ORG_DEPT: PSYCHOLOGY

ORG_NAME: UNIVERSITY OF WISCONSIN MILWAUKEE

ORG_STATE: WI

PHR: PROJECT NARRATIVE The University of Wisconsin-Milwaukee (UWM) has the most diverse student body in the Wisconsin public uni- versity system and is located in the most racially and ethnically diverse city in Wisconsin. The UWM Promoting Equity, Diversity, and Academic Success Through Aging Research (UWM STAR) program is designed to lever- age this diversity in support of the NIA’s goals for this R25 program: to expand research opportunities for un- derrepresented undergraduate students and increase the diversity of researchers conducting health disparities research among older adults. The program will provide structured multi-year hands-on research experiences, plus curricular and socialization experiences designed to prepare underrepresented college students for careers in aging and health disparities research.

PI_NAMEs: FRICK, KARYN M (contact)

PROGRAM_OFFICER_NAME: TORRES, DELANY

PROJECT_TERMS: Academic advising;Address;Adherence;Administrator;Affect;Age;Aging;American;Behavioral Sciences;Black race;Black, Indigenous, People of Color;career;Cities;Client satisfaction;cohort;Communities;Complex;Coupled;Dedications;design;Development;Disparate;Disparity;Drops;Education;Education Projects;Educational Background;Educational Curriculum;Educational workshop;Equity;ethnic diversity;experience;Exposure to;Face;Faculty;faculty community;Familiarity;Financial Support;Fostering;Future;Gerontology;Goals;Graduation Rates;hands on research;Health;health care quality;Health Disparities Research;health disparity;health inequalities;implicit bias;improved;Indigenous;Individual;Inequity;insight;Insurance;interest;Interview;Learning;Life;Literature;Location;Medical Research;Mentors;Mentorship;Minority;minority student;Motivation;neighborhood disadvantage;novel;older adult;Outcome;outreach;Patient Participation;peer;peer coaching;people of color;Population;Population Heterogeneity;Process;Program Evaluation;programs;Public Health;racial diversity;Reduce health disparities;remediation;Research;Research Personnel;retention rate;Schools;Science;Scientific Advances and Accomplishments;Scientist;Severity of illness;skills;social;social engagement;Social support;Socialization;Socioeconomic Status;Structure;Students;success;support network;System;Training;Training Programs;translational scientist;undergraduate research;undergraduate research experience;undergraduate student;Underrepresented Populations;Underrepresented Students;underserved community;Universities;university student;Visit;Wisconsin;Work

PROJECT_TITLE: UW-Milwaukee Promoting Equity, Diversity, and Academic Success Through Aging Research Program (UWM STAR)


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Aging;Clinical Research;Diabetes

ORG_CITY: BALTIMORE

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Narrative Diabetes is common in older adults and associated with major adverse health outcomes. State-of-the art continuous glucose monitoring (CGM) technology provides a novel means to rigorously characterize glucose patterns, but this technology has rarely been used in older adults. The proposed project will provide evidence- based guidance regarding the use and interpretation of continuous glucose monitoring in older adults.

PI_NAMEs: SELVIN, ELIZABETH  (contact)

PROGRAM_OFFICER_NAME: GOROSPE, RAFAEL

PROJECT_TERMS: Adult;Age;Atherosclerosis Risk in Communities;Biological Markers;blood glucose regulation;Cardiac;Cardiovascular Diseases;Clinical;clinical practice;clinically relevant;cognitive function;cohort;Continuous Glucose Monitor;Data;Development;Diabetes Mellitus;Diagnosis;Disease;evidence base;follow-up;frailty;Frequencies;Fructosamine;Funding;Future;Glucose;Glycosylated hemoglobin A;glycosylated serum albumin;Goals;Grant;Guidelines;Health;health related quality of life;Health Status;Homeostasis;human old age (65+);Hyperglycemia;Hypoglycemia;Impaired cognition;Investigation;Kidney;Laboratories;Lead;Manuscripts;Measurement;Measures;Methods;mortality;Motivation;non-diabetic;Non-Insulin-Dependent Diabetes Mellitus;novel;older adult;Outcome;Participant;Pattern;Peripheral Nervous System Diseases;Persons;Physical Function;Physiological;Population;Prediabetes syndrome;prognostic;prospective;Quality of life;Recommendation;response;Risk;Risk Factors;Serum;success;Technology;Time;Uncertainty;Variant;virtual;Visit;Vulnerable Populations;Work

PROJECT_TITLE: Clinical relevance of glucose patterns in older adults

STUDY_SECTION: KNOD

STUDY_SECTION_NAME: Kidney, Nutrition, Obesity and Diabetes Study Section[KNOD]


NIH_SPENDING_CATS: Biotechnology;Bipolar Disorder;Brain Disorders;Genetics;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Human Genome;Mental Health;Mental Illness;Precision Medicine;Prevention;Racial and Ethnic Minority Health Research;Schizophrenia;Serious Mental Illness

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PROJECT NARRATIVE This study will reduce health disparities and disease burden that disproportionally affect individuals of Latino ancestry suffering from schizophrenia and bipolar disorder. We will develop novel statistical methods and generate gene expression data that specifically apply to the admixed genetic ancestries within individuals of Latino ancestries. The integrative approach will significantly advance our understanding of the biological factors leading to disease susceptibility and provide great opportunity for personalized medicine.

PI_NAMEs: OPHOFF, ROEL A (contact);PASANIUC, BOGDAN

PROGRAM_OFFICER_NAME: PEVSNER, JONATHAN ABRAM

PROJECT_TERMS: Admixture;Affect;Alleles;Architecture;biobank;Biological;Biological Assay;Biological Factors;Bipolar Disorder;Blood specimen;burden of illness;case control;causal variant;cell type;Chromosome Mapping;clinically relevant;Data;data integration;Data Set;Diagnosis;differential expression;Disease;Disease susceptibility;Distal;European ancestry;Funding;Future;gene discovery;Gene Expression;Generations;Genes;Genetic;Genetic Predisposition to Disease;Genetic Research;Genetic Risk;genetic risk factor;genetic variant;Genetic Variation;Genome;genome wide association study;genome-wide;genomic locus;genomic tools;Genomics;health disparity;Heritability;improved;Individual;insight;Latin American;Latino;Latino Population;Link;Maps;Mediating;method development;Methods;Molecular;National Institute of Mental Health;Neuroglia;Neurons;novel;Patients;personalized genomic medicine;personalized medicine;Population;Population Heterogeneity;predictive modeling;Process;Reduce health disparities;Regulator Genes;Regulatory Element;Research;Resources;risk variant;Schizophrenia;schizophrenia risk;severe mental illness;Side;Signal Transduction;single-cell RNA sequencing;Statistical Methods;Susceptibility Gene;Time;Tissues;tool;trait;Transcript;transcriptome;transcriptome sequencing;transcriptomics;Translations;Underrepresented Populations;Validation;Variant;virtual;Vulnerable Populations

PROJECT_TITLE: Integrating case-control transcriptomic and genetic data in admixed individuals to identify disease genes for schizophrenia and bipolar disorder

STUDY_SECTION: NMBH

STUDY_SECTION_NAME: Neurological, Mental and Behavioral Health Study Section[NMBH]


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Pediatric

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative: This research will develop and validate machine learning methods for estimating brain micro-structural biomarkers from diffusion MRI measurements for neonates and pediatric patients. In addition to superior estimation accuracy, the new methods will compute prediction uncertainty, detect model failure, and enhance transparency and user trust. Hence, the new methods will enable assessment of normal and abnormal brain development in these critical stages with unprecedented accuracy and reliability.

PI_NAMEs: KARIMI, DAVOOD  (contact)

PROGRAM_OFFICER_NAME: MACHLIN, LAURA STONER

PROJECT_TERMS: Address;Adoption;Anatomy;Architecture;Assessment tool;Atlases;Attention;Biological Markers;biophysical model;Birth;Brain;brain abnormalities;Calibration;Childhood;Complex;Computer Vision Systems;connectome;Data;Data Set;deep learning;deep neural network;detection method;Development;Diffusion;Diffusion Magnetic Resonance Imaging;explainable machine learning;Failure;Goals;Human;Image;imaging study;improved;Integration Host Factors;interest;Knowledge;Learning;Machine Learning;machine learning method;machine learning model;machine learning prediction;magnetic resonance imaging biomarker;Maps;Mathematics;Measurement;Methods;Modeling;Neonatal;neonatal magnetic resonance imaging;neonate;Nervous System Disorder;neural network;neural network architecture;Noise;novel;pediatric patients;Population;Reliability of Results;Reproducibility;Research;Sampling;Scanning;self-attention;Signal Transduction;Software Tools;spatiotemporal;Structural Models;Structure;Techniques;Testing;tool;Trust;Uncertainty;Work

PROJECT_TITLE: Accurate, reliable, and interpretable machine learning for assessment of neonatal and pediatric brain micro-structure

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

ORG_CITY: ITHACA

ORG_NAME: CORNELL UNIVERSITY

PHR: Project Narrative Tissue resident macrophages are thought to play an important role in viral persistent because of their ability to survive HIV-1 infection, but have been understudied because of their paucity and inaccessibility. We propose addressing this shortfall through screening a small molecule library of epigenetic inhibitors to identify those pathways leading to selective cell death in a range of myeloid host cell lineages including HMDMs, alveolar macrophages, and microglial cells. Compounds identified as active will be assayed directly against HIV-1 positive patients’ cells, and characterized for the mode of action to identify novel therapeutic approaches towards HIV-1 reservoir eradication.

PI_NAMEs: RUSSELL, DAVID G (contact)

PROGRAM_OFFICER_NAME: LAWRENCE, DIANE M

PROJECT_TERMS: Address;Alveolar Macrophages;Apoptosis;Automobile Driving;Awareness;Biological;Biological Assay;Biological Products;Biology;Cell Death;Cell Death Induction;Cell Line;Cell Lineage;Cell Survival;Cells;Chemicals;Collaborations;Collection;Disease;drug discovery;Epigenetic Process;experience;fetal stem cell;Flow Cytometry;Fluorescent in Situ Hybridization;Gene Expression Profiling;Genes;Genetic Transcription;Goals;HIV Infections;HIV-1;Human;Infection;Inflammation;inhibitor;Introns;Knowledge;Kupffer Cells;Langerhans cell;latent infection;Libraries;Link;Luciferases;Lung;Lung infections;Lymphocyte;Macrophage;Maintenance;Malawi;Mediating;Metabolic;Methods;Microglia;Mitochondria;Modeling;Molecular Profiling;monocyte;Mus;Myelogenous;Myeloid Cells;novel therapeutic intervention;Outcome;Output;Pathway interactions;Patients;Pharmacotherapy;Phenocopy;Phenotype;Play;Population;Production;Productivity;programs;recruit;Regulatory Pathway;Reporter;Research;Respiration;response;Role;screening;self-renewal;single-cell RNA sequencing;Small Interfering RNA;small molecule;small molecule inhibitor;small molecule libraries;Sorting;Splenic Red Pulp;Therapeutic;Tissues;Traction;Transcript;Tuberculosis;tuberculosis drugs;Untranslated RNA;Viral;Virus;Visit;volunteer

PROJECT_TITLE: Modulation of epigenetic programming of tissue resident macrophage lineages to impact HIV-1 infection, maintenance, and persistence.


NIH_SPENDING_CATS: Clinical Research;Infectious Diseases;Malaria;Pediatric;Rare Diseases;Vector-Borne Diseases

ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: PROJECT NARRATIVE An NIH-funded trial will assess whether active detection and treatment of low-density malaria infection in children results in clinical benefits on long-term health. In this study, we will determine whether this intervention also reduces gametocyte carriage, thereby having the potential to interrupt malaria transmission. This will help inform policy and practice regarding the role of ultrasensitive malaria diagnostics to reduce transmission and help achieve malaria elimination.

PI_NAMEs: LIN, JESSICA  (contact)

PROGRAM_OFFICER_NAME: MO, ANNIE X  Y

PROJECT_TERMS: Acute;Adult;Africa South of the Sahara;African;Age;age group;Anopheles gambiae;Anti-malarials;Area;Area Under Curve;arm;artemether;benflumetol;Biological Assay;Bite;California;Child;Chronic;Clinical;cohort;Comparison arm;Consensus;Costs and Benefits;Culicidae;Data;density;Detection;Diagnostic;Disease;Dryness;feeding;Fever;Funding;Health;Human;human old age (65+);Individual;Infection;infection rate;Interruption;Intervention;Malaria;Malaria Diagnostic;malaria infection;malaria transmission;Measures;Modeling;Molecular;molecular diagnostics;Monoclonal Antibodies;Parasites;Participant;Periodicals;Pharmaceutical Preparations;point of care;Policies;Policy Maker;Prevalence;Preventive treatment;Primaquine;Randomized;rapid test;Residual state;Role;Rural;Sampling;San Francisco;School-Age Population;Schools;Science;Seasons;Skin;success;Symptoms;Tanzania;Target Populations;Testing;Time;Translating;transmission process;treatment arm;United States National Institutes of Health;Universities;vaccine distribution;Work

PROJECT_TITLE: Does treating low density malaria infections reduce malaria transmission?

STUDY_SECTION: CRFS

STUDY_SECTION_NAME: Clinical Research and Field Studies of Infectious Diseases Study Section[CRFS]


ORG_NAME: BRIGHAM AND WOMEN'S HOSPITAL

PHR: PROJECT NARRATIVE The proposed research aims to develop a framework for the detection and evaluation of clinically relevant drug-drug interactions in older adults with diabetes using electronic healthcare data. The overarching goal is to produce actionable, high-quality, and clinically relevant evidence that will help older adults and their clinicians to more fully assess the benefits and risks of adding a new medication in the presence of other medications and co-morbidities. This research will improve the evidence-base for decision-making available to clinicians treating older adults with diabetes, ultimately enhancing patient care, which is aligned with the mission of the National Institute on Aging (NIA).

PI_NAMEs: BYKOV, KATSIARYNA  (contact)

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TERMS: active comparator;Address;Adverse effects;Adverse event;Affect;Age;age related;Aging;Alternative Therapies;Area;Benefits and Risks;Biometry;career development;Clinical;clinical decision-making;clinically actionable;clinically relevant;Cohort Studies;comorbidity;Complex;Complications of Diabetes Mellitus;Crossover Design;Data;data mining;Decision Making;design;Detection;detection method;detection platform;Development;Diabetes Mellitus;Doctor of Pharmacy;drug development;Drug Evaluation;Drug Interactions;Drug usage;eHealth;Elderly;Electronic Health Record;Environment;Epidemic;Epidemiologist;Epidemiology;Evaluation;evidence base;Exclusion;experience;Exposure to;Face;Fracture;frailty;functional status;Geriatrics;Goals;Health;Health Insurance;Health Status;Healthcare;Heterogeneity;Hospitals;Hypoglycemia;Impaired cognition;improved;In Vitro;inhibitor;innovation;Institution;instructor;insurance claims;International;Knowledge;Laboratories;Link;medical schools;Medicare claim;Medicine;Mentored Research Scientist Development Award;Mentors;Mentorship;Methodology;Methods;Mission;Modification;multiple chronic conditions;National Institute on Aging;novel;novel strategies;Observational Study;older adult;Outcome;Outpatients;Patient Care;patient subsets;Patients;Pennsylvania;Pharmaceutical Economics;Pharmaceutical Preparations;Pharmacoepidemiology;Pharmacology;Physiological;Polypharmacy;Population;Population Study;Positioning Attribute;Predisposition;Premature Mortality;Productivity;programs;randomized, clinical trials;Research;research clinical testing;Research Personnel;response;Risk;Risk Factors;Scanning;screening;sex;Signal Transduction;skills;Solid;Statistical Methods;Subgroup;Sulfonylurea Compounds;Syndrome;Test Result;Testing;Time;tool;Training;Translating;Trees;United States Food and Drug Administration;Universities;Woman;Work

PROJECT_TITLE: Novel approaches to identify and quantify the impact of drug-drug interactions in older adults with diabetes, with a focus on multimorbidity and polypharmacy

STUDY_SECTION: NIA

STUDY_SECTION_NAME: Clinical Aging Study Section[NIA-C]


NIH_SPENDING_CATS: Aging;Clinical Research;Eye Disease and Disorders of Vision;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: HANOVER

ORG_NAME: DARTMOUTH COLLEGE

ORG_STATE: NH

PHR: Project Narrative Successful navigation requires the integration of our remembered environment with the scene in front of us, but little is known about how spatial memory and scene perception systems interact in the brain. Closing this knowledge gap is the overall objective of this proposal. This work is crucial to informing rehabilitation and support strategies for individuals with reduced vision (e.g. Macular Degeneration), neurodegenerative conditions (e.g. Alzheimer’s disease), developmental disorders (e.g. Williams syndrome), and typical aging, in which scene recognition and wayfinding abilities are key symptoms affecting day-to-day life and, in some neurodegenerative conditions, the first detected signs of decline.

PI_NAMEs: ROBERTSON, CAROLINE ELIZABETH (contact)

PROGRAM_OFFICER_NAME: RANGEL GOMEZ, MAURICIO

PROJECT_TERMS: Affect;Aging;Alzheimer's Disease;Anterior;Area;Behavior;Biological Models;Brain;Brain region;cerebral visual impairment;Code;Data;Dementia;developmental disease;Educational process of instructing;Environment;expectation;experience;Functional Magnetic Resonance Imaging;Grain;Head;Health;healthy aging;Hippocampus;Human;Individual;insight;Knowledge;knowledge of results;Learning;Life;Macular degeneration;member;Memory;multimodality;Nature;Nerve Degeneration;neural;Neurodegenerative Disorders;Neurosciences;novel;novel strategies;Participant;pathological aging;Pattern;Perception;Population;predictive modeling;Published Comment;Rehabilitation therapy;Research;response;retinotopic;Saccades;Semantics;Shapes;Signal Transduction;spatial memory;Steel;Structure;Support System;Symptoms;System;Testing;virtual reality;virtual reality headset;Vision;Visual;Visual Cortex;Visual impairment;Visual Perception;visual processing;visual tracking;Visuospatial;way finding;Williams Syndrome;Work

PROJECT_TITLE: How Visuospatial Memory Shapes Perception of Real-World Environments

STUDY_SECTION: HCMF

STUDY_SECTION_NAME: Human Complex Mental Function Study Section[HCMF]


NIH_SPENDING_CATS: Cardiovascular;Clinical Research;Clinical Trials and Supportive Activities;Contraception/Reproduction;Hypertension;Maternal Health;Maternal Morbidity and Mortality;Pregnancy;Prevention;Women's Health Research

ORG_DEPT: OBSTETRICS & GYNECOLOGY

PHR: Project Narrative: This career development proposal leverages an expert multinational mentorship team and rigorous didactics to acquire essential skills for an independent global health research career. The research project addresses a critical knowledge gap, implementing and evaluating a home blood pressure monitoring intervention among women at risk of hypertensive disorders of pregnancy in Ghana. Expertise will be gained in survey questionnaire design, applied mixed methods, advanced quantitative methods, and reproductive health in Sub- saharan Africa.

PI_NAMEs: LAWRENCE, EMMA RACHEL (contact)

PROGRAM_OFFICER_NAME: LEVINTOVA, MARYA

PROJECT_TERMS: 2 arm randomized control trial;Address;Adherence;Adult;Africa South of the Sahara;arm;Blood Pressure;blood pressure elevation;Blood Pressure Monitors;career;career development;Caring;Cellular Phone;Chronic;Clinic Visits;Clinical;Country;Data;Development Plans;Diagnosis;Discipline of obstetrics;Early Diagnosis;Eclampsia;Education;Effectiveness;effectiveness testing;Electronics;evidence base;Face;Frequencies;Ghana;global health;Goals;Gynecologist;Healthcare Systems;High Risk Woman;Home;Home Blood Pressure Monitoring;Hypertension;improved;Income;informant;innovation;Intervention;intervention refinement;Interview;K-Series Research Career Programs;Knowledge;low and middle-income countries;low health literacy;maternal morbidity;Maternal Mortality;mathematical ability;Measures;Mentorship;Methodology;Methods;Michigan;Morbidity - disease rate;mortality;Neonatal;neonatal outcome;Nurses;Outcome;Paper;Participant;Patients;Population;Pre-Eclampsia;Pregnancy;pregnancy disorder;Pregnancy Outcome;pregnant;Pregnant Women;prenatal;prevent;preventable death;primary outcome;Process;programs;Questionnaire Designs;Randomized, Controlled Trials;Recommendation;recruit;Reporting;Reproductive Health;Research;research and development;Research Personnel;Research Project Grants;Resource-limited setting;Schedule;secondary outcome;Seizures;skills;Stroke;Structure;Surveys;Technology;Telephone;Time;Training;Triage;trial comparing;trial design;Universities;Visit;Woman;Women's Health

PROJECT_TITLE: Home blood pressure monitoring among women at risk of hypertensive disorders of pregnancy in Ghana

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-ICP-G(55)R]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Social Determinants of Health

ORG_NAME: STANFORD UNIVERSITY

PHR: PROJECT NARRATIVE The Stanford Population Health Aging Research-Advancing Health Equity and Diversity (PHAR-AHEaD) summer program is an 8-week training and research experience for college students from underrepresented and historically excluded groups in the health sciences. Our goal is to support scholars from diverse backgrounds to graduate education and research in aging and population health.

PI_NAMEs: ODDEN, MICHELLE CHRISTINA (contact);REHKOPF, DAVID H

PROJECT_TERMS: Academia;academic standard;Admission activity;Aging;career;career development;cohort;college;community engagement;Complement;Complex;Data Collection;Development;Discipline;diversity and equity;Economics;Education;Education Projects;Educational Curriculum;Enrollment;Environment;Epidemiology;Equity;Exclusion;experience;Faculty;faculty mentor;Fees;Fostering;Foundations;Funding;Future;Goals;Graduate Education;graduate school;graduate student;health equity;Health Policy;Health Sciences;healthy aging;Inequality;innovation;Institution;Instruction;interest;Lead;Learning;Life Cycle Stages;Link;medical schools;member;Mentors;Mentorship;Methods;next generation;Participant;peer;population health;Population Research;Postdoctoral Fellow;Preparation;programs;recruit;Reporting;Research;Research Design;Research Personnel;Research Project Grants;Science;science, technology, engineering, mathematics, and medicine;skills;Societies;statistics;STEM field;Students;success;summer program;Testing;Training;Training Programs;Transcript;Underrepresented Populations;Underrepresented Students;Universities;university student;volunteer

PROJECT_TITLE: Population Health Aging Research - Advancing Health Equity and Diversity (PHAR-AHEaD)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Clinical Research;Coronaviruses;Coronaviruses Disparities and At-Risk Populations;Data Science;Emerging Infectious Diseases;Health Services;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Patient Safety;Pediatric;Prevention

ORG_CITY: NEW HAVEN

ORG_DEPT: PEDIATRICS

ORG_NAME: YALE UNIVERSITY

PHR: PROJECT NARRATIVE Fear of the novel coronavirus (SARS-CoV-2) is widespread, and the emotional toll of this virus on our society is enormous. However, relatively little is known about the effects of this virus on children. Empiric estimates on the risks and long-term effects of this virus in children will enable clinicians and policymakers to make informed decisions about both the need for optimal use of preventative and therapeutic interventions as they become available.

PI_NAMEs: OLIVEIRA, CARLOS RAFAEL (contact)

PROGRAM_OFFICER_NAME: BOZICK, BROOKE ALLISON

PROJECT_TERMS: 18 year old;2019-nCoV;Accident and Emergency department;Adult;Affect;Algorithms;biomedical informatics;Body System;Caring;Child;Child Care;Childhood;Clinic;Clinical;clinical care;Clinical Data;clinical epidemiology;clinical predictive model;clinical predictors;clinical risk;cohort;Communicable Diseases;Complement;computer program;computerized tools;Country;COVID-19;COVID-19 incidence;COVID-19 patient;COVID-19 severity;COVID-19 surveillance;Critical Illness;Cross-Sectional Studies;Data;data access;Data Analyses;Data Science;Data Set;design;Detection;Deterioration;Diagnosis;Discipline;Disease;economic cost;Educational workshop;Electronic Health Record;Emerging Communicable Diseases;Emerging infection;Emotional;Enrollment;Epidemiology;experience;Failure;follow-up;Frequencies;Fright;Functional disorder;Funding;Future;future pandemic;Goals;gradient boosting;Health Care Costs;health related quality of life;Health system;Hospitalization;Hospitalized Child;Hospitals;Hour;improved;Infection;Informatics;Infrastructure;International;Intervention;Investigation;Laboratories;Literature;Long-Term Effects;longitudinal analysis;Longitudinal cohort;Longitudinal cohort study;Longitudinal Studies;Machine Learning;machine learning model;Manuals;mathematical model;Medical center;Mentored Patient-Oriented Research Career Development Award;Mentors;Mentorship;Modeling;multidisciplinary;Multisystem Inflammatory Syndrome in Children;Names;Natural Language Processing;novel;novel coronavirus;Organ;Outcome;pandemic disease;Patient Self-Report;Patient-Focused Outcomes;Patients;Pediatric epidemiology;Phenotype;Physicians;Policy Maker;predictive modeling;prevent;preventive intervention;programs;Protocols documentation;public health relevance;Quality of Life Assessment;Recovery;recruit;Registries;Reporting;Research;Research Personnel;Respiratory Disease;Risk;Risk Factors;SARS-CoV-2 infection;SARS-CoV-2 positive;Science;Scientist;severe COVID-19;Severities;Shock;Site;skills;Societies;Standardization;State Hospitals;Structure;structured data;Symptoms;Syndrome;System;systemic inflammatory response;Testing;Therapeutic Intervention;tool;Training;United States;unstructured data;Ventilator;Virus;Work

PROJECT_TITLE: Clinical Epidemiology of Pediatric COVID-19 and MIS-C

STUDY_SECTION: MID

STUDY_SECTION_NAME: Microbiology and Infectious Diseases B Research Study Section[MID-B]


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics;Pediatric;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human;Transplantation

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

PHR: NARRATIVE Close to 10% of the over 20,000 premature children every year develop airway disorders that often require laryngotracheal reconstruction using cartilage harvested from the rib cage, but this approach is invasive and cannot be applied to younger children, which motivates an urgent need for new, improved technology. We propose an innovative approach to produce functional cartilage for grafting using an instructive, degradable scaffold that direct the chondrogenic differentiation of a novel autologous cell sources obtained by a minimally invasive biopsy. The in vitro and in vivo proposed studies are aimed at defining new, less invasive and more effective therapeutic options for laryngotracheal reconstruction.

PI_NAMEs: GOTTARDI, RICCARDO  (contact)

PROGRAM_OFFICER_NAME: NATARAJAN, ARUNA R

PROJECT_TERMS: Acids;Adolescent;adverse outcome;Affect;Air Movements;Animals;Autologous;Biochemistry;Biopsy;calcification;Cartilage;cartilage implant;cartilage transplantation;cartilaginous;Cells;Cellular Metabolic Process;Child;Childhood;Chondrocytes;Chondrogenesis;Clinic;Clinical;clinical translation;clinically relevant;Cognitive;Collagen;costal cartilage;Cultured Cells;Development;Diagnosis;Diameter;Dimensions;Disease;DNA;Ear;Ear Cartilages;efficacy validation;Engineering;Ensure;Euthanasia;Exhibits;Face;Family suidae;GAG Gene;Gene Expression;Goals;graft failure;Harvest;Hormones;Hypertrophy;Hypoxia;Immunohistochemistry;Implant;implantation;improved;In Vitro;in vivo;Incidence;Infection;innovation;Intubation;manufacturing scale-up;mechanical properties;Mechanics;Mesenchymal;Mesenchymal Stem Cells;Metabolic;meter;Microfluidics;minimally invasive;Modeling;Modulus;Monitor;Morbidity - disease rate;mortality;Mus;novel;Operative Surgical Procedures;Outcome;Oxygen;Patients;Pattern;Phenotype;Physical condensation;Polymers;porcine model;Porosity;pre-clinical;preclinical safety;premature;Premature Birth;Procedures;Production;Proliferating;Quality of life;Quantitative Reverse Transcriptase PCR;reconstruction;Reconstructive Surgical Procedures;response;restenosis;restoration;rib bone structure;Risk;RNA;safety study;scaffold;Scientist;Second Look Surgery;Site;Source;Speech;stem cells;Stenosis;Structure;subcutaneous;success;Surgeon;Technology;Testing;therapeutically effective;Thick;Thinness;Time;timeline;Tissue Engineering;Tissues;Tracheotomy procedure;transcriptome sequencing;Translations;Triiodothyronine;United States;vocal cord;Work

PROJECT_TITLE: Laryngotracheal Reconstruction with Engineered Cartilage

STUDY_SECTION: MTE

STUDY_SECTION_NAME: Musculoskeletal Tissue Engineering Study Section[MTE]


NIH_SPENDING_CATS: Brain Disorders;Cardiovascular;Cerebrovascular;Disability Research;Genetics;Neurosciences;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: TUCSON

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative: The brain damage is far too common in the preterm neonates. The proposed research will identify the mechanism to prevent brain damage in the preterm neonates. The research will be conducted in vivo in the preterm fetus to identify therapeutically relevant targets to control blood flow to the brain.

PI_NAMEs: GOYAL, RAVI  (contact)

PROGRAM_OFFICER_NAME: GUMINA, DIANE LAURA

PROJECT_TERMS: Acetylation;Adrenergic Agents;Adrenergic Agonists;Adrenergic Receptor;alpha-1 adrenergic receptors;Animals;Basic Science;Biological Assay;Birth;Blood flow;Blood Pressure;blood pressure elevation;Brain;Brain Injuries;Carotid Arteries;Catecholamines;Catheterization;cerebral autoregulation;cerebral capillary;Cerebrovascular Circulation;Cerebrum;Chronic;cognitive disability;constriction;Data;differential expression;disability;Disabled Persons;DNA;DNA Methylation;Epigenetic Process;Excision;experimental study;Face;Family;fetal;Fetal Sheep;Fetus;Gene Expression;Gestational Age;Histone Acetylation;histone modification;Homeostasis;Hormones;Human;Hypermethylation;Impairment;in utero;in vivo;Incidence;Infant;insight;Knowledge;Laser-Doppler Flowmetry;Learning Disabilities;Life;life-long learning;Low Birth Weight Infant;Luciferases;Measurement;Measures;Methylation;neonate;Nervous System;Neurologic;Newborn Infant;Organism;Outcome;Pathway interactions;Phenylephrine;Play;Premature Birth;Premature Infant;pressure;preterm newborn;prevent;promoter;receptor;Regulation;Reporter;Research;response;Role;Rupture;Series;sex;Sheep;Side;Stress;Structure of superior cervical ganglion;System;Systemic blood pressure;Testing;Therapeutic;Time;transmission process;women versus men

PROJECT_TITLE: The role of Alpha1-Adrenergic Receptors Promoter Methylation in Cerebral Autoregulation in Fetus

STUDY_SECTION: PN

STUDY_SECTION_NAME: Pregnancy and Neonatology Study Section[PN]


NIH_SPENDING_CATS: Aging;Behavioral and Social Science;Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Prevention;Social Determinants of Health

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: PROJECT NARRATIVE In the United States (US), transgender and gender diverse (TGD) individuals, who have a gender identity that differs from their assigned birth sex, experience disparities in the burden of chronic conditions and healthcare use relative to their cisgender (non-TGD) peers. There is limited national data on whether and to what extent these disparities persist as TGD individuals age. This study will utilize a rigorous mixed-methods approach that combines quantitative data from a large cohort of older TGD and cisgender adults with qualitative interviews with patients and providers to provide clinically-important and policy-relevant evidence about the health and healthcare utilization of older TGD and cisgender adults; findings will be leveraged in future multilevel interventions to improve health outcomes for older TGD people in the US.

PI_NAMEs: HUGHTO, JACLYN WHITE;MEYERS, DAVID JOSEPH (contact)

PROGRAM_OFFICER_NAME: NOVAK, PRISCILLA JOY

PROJECT_TERMS: Acute;acute care;Address;Adult;Age;Algorithms;beneficiary;Birth;Caring;Chronic;cisgender;Cities;Climate;Clinical;Cognition;cohort;community barrier;community based research;community-level factor;comorbidity;Data;Data Linkages;Data Set;Data Sources;Disparity;Environmental Risk Factor;experience;Future;gender affirmation;gender diverse;Gender Identity;gender minority group;Geography;Goals;Health;health assessment;health care quality;health care service utilization;health difference;health disparity;Healthcare;healthcare burden;Healthcare Systems;high risk;Hormones;improved;Incidence;Individual;innovation;Intervention;Interview;Life Cycle Stages;Link;marginalization;Medical;Medicare;member;Methods;novel;older adult;Operative Surgical Procedures;Outcome;Outpatients;Patients;peer;Persons;Policies;Politics;poor health outcome;Population;Population Heterogeneity;Predisposition;Prevalence;Process;Provider;Qualitative Methods;racial minority;Research;Resources;Risk;routine care;Sampling;Services;sex;sexual minority group;sexual minority health;Shapes;social stigma;socioeconomics;Source;Stress;structural determinants;theories;Training;transgender;United States;United States National Institutes of Health;Woman;Work

PROJECT_TITLE: Examining Health Comorbidities and Healthcare Utilization Disparities among Older Transgender and Cisgender Adults in the U.S.

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases;Influenza;Lung;Pneumonia and Influenza;Prevention

ORG_DEPT: SURGERY

PHR: Project Narrative The current proposal seeks to understand why and how influenza virus lung infection induces ACE2 expression and activity, and in turn facilitates the compromised immune response to secondary bacterial lung infection. We will also try to test the potential preventive and therapeutic usage of ACE2 as a biomarker and clinical reagent.

PI_NAMEs: JIA, HONGPENG  (contact)

PROGRAM_OFFICER_NAME: ARNOLD, MICHELLE MARIE

PROJECT_TERMS: ACE2;Antibiotic Therapy;Antibiotics;Attenuated;Bacteria;Bacterial Infections;Bacteriophages;Biological Markers;Biology;Blood Pressure;chemokine;Clinical;clinically relevant;co-infection;comorbidity;Data;Defect;desensitization;Disease Outbreaks;Excess Mortality;Gene Targeting;Goals;Host Defense;Human;IL17 gene;Immune;Immune response;Immunity;Impairment;improved outcome;Infection;Inflammation;Inflammatory Response;Influenza;Influenza A virus;influenzavirus;Innate Immune Response;insight;Interferon Type II;Intervention;Invaded;Link;Lung;Lung Diseases;Lung infections;Mediating;Methodology;Microbe;Molecular;Monitor;mouse model;Mus;Natural Immunity;neutrophil;Neutrophil Infiltration;novel;novel marker;novel therapeutic intervention;novel therapeutics;Organoids;pathogen;Pathogenesis;pathogenic bacteria;pharmacologic;Physiological;Play;pre-clinical;prevent;Prevention strategy;Preventive;Probability;Production;Public Health;Reagent;Recovery;Regulation;Renin-Angiotensin System;Resistance;response;Role;Secondary to;Serum;Severities;Signal Pathway;Signal Transduction;Testing;Therapeutic;Therapeutic Uses;Time;tool;Viral;Viral Pathogenesis;Virus Diseases

PROJECT_TITLE: The role of ACE2 in Influenza viral infection mediated immune compromise and subsequent bacterial lung infection

STUDY_SECTION: LCMI

STUDY_SECTION_NAME: Lung Cellular, Molecular, and Immunobiology Study Section[LCMI]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Opioid Misuse and Addiction;Opioids;Patient Safety;Racial and Ethnic Minority Health Research;Social Determinants of Health;Substance Misuse;Telehealth

ORG_CITY: NEW YORK

ORG_DEPT: PSYCHIATRY

ORG_NAME: NEW YORK UNIVERSITY SCHOOL OF MEDICINE

ORG_STATE: NY

PHR: Project Narrative Transition age adults (ages 18-25) with opioid use disorders are poorly served by the current treatment system for substance use disorders. This study will examine the variation in quality of treatment for opioid use disorders for this age cohort and examine multilevel factors—individual, community, treatment program— associated with higher quality care. The findings from this study will inform clinical decision making by patients and providers as well as public health responses to the rising tide of young adults seeking treatment for OUD.

PI_NAMEs: NEIGHBORS, CHARLES J (contact)

PROGRAM_OFFICER_NAME: LYNCH, SEAN EDWARD WINTERS

PROJECT_TERMS: Adherence;Adult;Adverse event;Age;age group;Biological;Brain;Budgets;Buprenorphine;Caring;Characteristics;Client;Clinical;clinical care;clinical decision-making;cohort;Communities;community-level factor;comorbidity;Complex;contextual factors;Counseling;COVID-19;critical developmental period;Development;Diagnosis;Dose;Early treatment;Ecology;effective therapy;efficacious treatment;ethnic disparity;Event;Family;Government;Homelessness;Hospitals;improved;Incentives;indexing;Individual;Informal Social Control;Lead;Longitudinal Studies;Medicaid;medication for opioid use disorder;Mental Health;Methadone;Modeling;multiple data sources;Naltrexone;Neurologic;opioid use disorder;Organizational Change;organizational structure;Outcome;Overdose;parental monitoring;Patients;peer;Pharmaceutical Preparations;Pharmacotherapy;Policies;Population;Poverty;Prevalence;Process;Process Measure;programs;Provider;psychologic;Public Health;public health emergency;Quality of Care;racial disparity;Registries;response;Rewards;Role;social;Social Change;social expectations;social health determinants;social vulnerability;structural determinants;Structure;Substance Use Disorder;System;telehealth;Telemedicine;Time;treatment program;Variant;young adult

PROJECT_TITLE: Organizational factors associated with quality of care for opioid use disorders among transition-age adults in Medicaid

STUDY_SECTION: ODHS

STUDY_SECTION_NAME: Organization and Delivery of Health Services Study Section[ODHS]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Genetics;Human Genome

ORG_CITY: HOUSTON

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

PHR: This proposal will leverage high coverage long and short-read sequencing data to develop novel computational methods to improve the characterization of somatic and mosaic structural variation (SV) and transposition events together with their epigenetic consequences across three tissues and 34 individuals. The methods will be developed in coordination with the SMaHT network, and tools and results will be shared with all sequencing centers, in coordination with the DAC, enabling seamless incorporation of the software and our results into the network. The results will include a catalog of SV, transposition and methylation, in somatic tissues, that will enable new insights into the consequences of these variants, across the human population.

PI_NAMEs: SEDLAZECK, FRITZ J (contact);WU, TAO

PROGRAM_OFFICER_NAME: MORRIS, JILL A

PROJECT_TERMS: Address;Algorithms;analytical method;Attention;Awareness;Belief;Benchmarking;Biology;Blood;Brain;Catalogs;Collaborations;Communities;Complex;Computer software;Computing Methodologies;cost;Data;Detection;Disease;DNA;DNA Sequence;DNA Sequence Alteration;DNA Transposable Elements;Elements;Ensure;Epigenetic Process;Ethnic Origin;Evaluation;Event;Feedback;Fostering;Frequencies;Gene Expression;Genes;genetic variant;Genome;Genomic Segment;Germ Lines;hackathon;Human;Human Genome;human reference genome;improved;Individual;insight;Knowledge;Laboratories;Liver;Location;Machine Learning;Malignant Neoplasms;Measures;method development;Methodology;Methods;Methylation;methylation pattern;Modification;mosaic;mosaic variant;Mosaicism;Movement;Mutation;novel;Phase;Population;Production;Recording of previous events;Research Personnel;Resolution;Shapes;Short Tandem Repeat;Signal Transduction;Single Nucleotide Polymorphism;Somatic Mutation;Statistical Models;Tandem Repeat Sequences;Technology;telomere;Tissues;tool;Variant;variant detection;Work

PROJECT_TITLE: Identification of somatic/ mosaic SV and transposon activity and their crosstalk to DNA epigenetic Modifications

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CDB-K(70)R]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Eye Disease and Disorders of Vision;Macular Degeneration;Neurodegenerative;Neurosciences;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: IOWA CITY

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: NARRATIVE Recent advances in induced pluripotent stem cell (iPSC) technology have made it possible to produce autologous patient-derived retinal cells for analysis of disease pathophysiology and testing of novel therapeutics. That said, even state-of-the-art retinal differentiation protocols, which give rise to three dimensional retinal organoids, do not accurately recapitulate the cell-cell interactions that are present in the outer retina. In this application we describe a program focused on the development and validation of a microphysiological system engineered to accurately recreate the complex architecture of the perfused outer retina.

PI_NAMEs: MULLINS, ROBERT FOSTER;STONE, EDWIN M;TUCKER, BUDD A (contact)

PROGRAM_OFFICER_NAME: NEUHOLD, LISA

PROJECT_TERMS: 3-Dimensional;3D Print;Age related macular degeneration;Architecture;Autologous;Biological Models;Biomimetics;Blindness;Cell Communication;Cell Culture Techniques;cell type;Cells;Cessation of life;Complex;Custom;Degenerative Disorder;Deposition;Development;differentiation protocol;Disease;disease mechanisms study;Dropout;drug development;drug testing;Drusen;Endothelial Cells;Engineering;Functional disorder;Future;Genes;Hereditary Disease;Human;human induced pluripotent stem cells;human model;in vitro Model;Individual;induced pluripotent stem cell;induced pluripotent stem cell technology;Inherited;lithography;Microfluidics;microphysiology system;Modeling;monolayer;Mutation;Nervous System;Neural Retina;next generation;novel therapeutics;Nuclear;Organoids;Patients;Perfusion;Photoreceptors;Polymers;Porosity;Printing;programs;Retina;Retinal Degeneration;scaffold;Scientist;single-cell RNA sequencing;System;Testing;therapeutic gene;Tissue Differentiation;Tissue Donors;Tissues;two-photon;ultra high resolution;Validation

PROJECT_TITLE: A Next Generation Outer Retinal Microphysiological System


NIH_SPENDING_CATS: Bioengineering;Biotechnology;Genetics

ORG_CITY: ATLANTA

ORG_DEPT: PHYSICS

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE DNA mechanics and supercoiling, binding and bridging by proteins, and liquid-liquid phase separation shape the topology of the genome. Macromolecular crowding influences each of these phenomena affecting all fundamental genomic functions, including transcription. Experiments employing single molecule manipulation and modeling, and comparison with in vivo measurements will enhance our understanding of crowding-mediated genomic regulation and our ability to apply crowding in synthetic biology.

PI_NAMEs: FINZI, LAURA  (contact)

PROGRAM_OFFICER_NAME: SAKALIAN, MICHAEL

PROJECT_TERMS: Affect;Affinity;Binding;Biophysics;Cell Nucleolus;Crowding;Cytoplasmic Granules;DNA;DNA Maintenance;DNA Structure;DNA-Directed RNA Polymerase;Escherichia coli;experimental study;Genetic Transcription;Genome;Genomic Segment;Genomics;In Vitro;in vivo;laser tweezer;Learning;Liquid substance;Magnetism;Measurement;Mechanics;Mediating;melting;Modeling;Molecular Biology;Motor;novel;Oligonucleotides;optic tweezer;Phase;Physical condensation;Probability;Process;Proteins;Regulation;segregation;Shapes;single molecule;synthetic biology;System;Techniques;Temperature;tool

PROJECT_TITLE: Macromolecular Crowding effects on DNA mechanics, topology and transcription

STUDY_SECTION: MRAB

STUDY_SECTION_NAME: Maximizing Investigators’ Research Award B Study Section[MRAB]