NIH_SPENDING_CATS: Hearing Loss;Neurosciences

ORG_CITY: CHARLOTTESVILLE

ORG_NAME: UNIVERSITY OF VIRGINIA

ORG_STATE: VA

PHR: PROJECT NARRATIVE This proposal will describe a previously unknown mechanism of postnatal neuron and synapse pruning in the mammalian cochlea. Data generated from these experiments will build upon our knowledge of the function of both membrane dynamics and supporting cells in postnatal cochlear development. Understanding this process could provide insight into the prevention of hearing loss, which affects approximately 1 in 5 people worldwide (World Health Organization World Report on Hearing).

PI_NAMEs: NIMCHUK, KATHERINE  (contact)

PROJECT_TERMS: Affect;ANXA5 gene;Apoptosis;Auditory;Auditory Brainstem Responses;Brain;Calcium and Integrin Binding Protein 2;Cell membrane;Cell Physiology;cell type;Cells;Cochlea;cochlear development;Communication;Data;density;Development;disability;Ear;Eating;Excision;expectation;experimental study;Family;Flow Cytometry;Hair Cells;Hearing;hearing impairment;Hearing Tests;Human;Immunofluorescence Immunologic;Impairment;Inner Hair Cells;insight;Intervention;Investigation;Knock-out;Knowledge;Label;Labyrinth;Left;Lipids;Literature;Lysosomes;mechanotransduction;Mediating;Mediator;member;Membrane;Modeling;Molecular;Mus;Mutation;nerve supply;nervous system development;neuronal cell body;Neurons;otoacoustic emission;Outer Hair Cells;Pathway interactions;Persons;Phagocytes;Phagocytosis;Phase;phosphatidylserine receptor;Phosphatidylserines;Positioning Attribute;postnatal;postnatal development;prevent;prevent hearing loss;Process;receptor;Receptor Protein-Tyrosine Kinases;Reporting;Role;Sensory Hair;Signal Transduction;spiral ganglion;Supporting Cell;Synapses;synaptic pruning;Testing;Type II Hair Cell;United States;Variant;Visual impairment;Work;World Health Organization

PROJECT_TITLE: Phosphatidylserine signaling in neuronal refinement of the cochlea


ADMINISTERING_IC: MH

ARRA_FUNDED: N

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Clinical Research;Mental Health;Neurosciences

ORG_CITY: BOSTON

ORG_COUNTRY: UNITED STATES

ORG_FIPS: US

ORG_NAME: MASSACHUSETTS GENERAL HOSPITAL

ORG_STATE: MA

PHR: PROJECT NARRATIVE Functional Magnetic Resonance Imaging (fMRI) is a common tool for measuring human brain function, but it does not measure neuronal firing directly—instead it tracks changes in blood delivery and blood oxygen that accompany this neuronal activity. New evidence shows that the brain is capable of controlling these “hemodynamic” changes finely enough to use it to identify neuronal activity at the scale of the “layers” of the cerebral cortex, which are the inputs and outputs of brain circuits, yet, unfortunately, the imaging resolution of modern fMRI is not high enough to resolve these layers. To address this, in this F32 fellowship we propose to develop a high-resolution one-dimensional imaging approach called “linescan fMRI” that rapidly scans across the cerebral cortical layers, then fully characterize its performance, validate it as a tool for measuring brain activity within cerebral cortical layers, then apply it to a new experiment we have designed, all to establish linescan fMRI as a mainstream tool for human neuroscience.

PI_NAMEs: YUSIF RODRIGUEZ, NADIRA DEL R. (contact)

PROGRAM_OFFICER_NAME: CHURCHILL, JAMES D

PROJECT_TERMS: Accounting;Address;Animal Model;area striata;attentional modulation;Benchmarking;Blood;Blood capillaries;Blood flow;blood oxygen level dependent;Brain;brain circuitry;Brain region;career;Cerebral cortex;Cognition;Communication;Communities;Computers and Advanced Instrumentation;Coupled;Data;design;Development;Educational workshop;Electrodes;Electrophysiology (science);Environment;experimental study;Fellowship;Functional Magnetic Resonance Imaging;functional MRI scan;General Hospitals;Goals;hemodynamics;high resolution imaging;Human;human subject;Human Subject Research;Image;imaging approach;improved;Individual;Macaca;Magnetic Resonance Imaging;Mainstreaming;Maps;Massachusetts;Measurement;Measures;meetings;Mentors;Mentorship;Methods;Modernization;Monkeys;MRI Scans;neural;Neurons;Neurosciences;neurovascular coupling;Noise;novel;novel strategies;Output;Oxygen;Pattern;Performance;Photic Stimulation;Physics;Physiological;Population;Positioning Attribute;Proxy;receptive field;research facility;Research Infrastructure;Research Personnel;Research Project Summaries;Resolution;response;responsible research conduct;Scanning;Series;Signal Transduction;Slice;Specificity;Techniques;Technology;temporal measurement;Testing;Thick;Time;tool;Training;Trust;ultra high resolution;Work

PROJECT_TITLE: Advanced functional MRI of cerebral cortical layers in the human brain using ultrahigh-resolution linescan MRI technology

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03B-L (20)]


ADMINISTERING_IC: DE

ED_INST_TYPE: SCHOOLS OF MEDICINE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Cancer;Cancer Genomics;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Human Genome;Rare Diseases

ORG_CITY: AMHERST

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: STATE UNIVERSITY OF NEW YORK AT BUFFALO

ORG_STATE: NY

PHR: PROJECT NARRATIVE Oral Squamous Cell Carcinoma (OSCC) is a common and complex disease with limited therapeutic options. We propose to investigate how cancer cells communicate with other supporting cells in the OSCC tumor microenvironment to facilitate the progression of this disease. Such studies are essential for understanding the mechanism(s) by which cancer cells grow and spread, and for identification of candidate biomarkers and therapeutic targets to better diagnose and treat OSCC.

PI_NAMEs: SOSA, JENNIFER  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Ablation;Address;Adhesives;Affect;Aggressive behavior;Alcohols;Animal Model;Apoptosis;Attention;Automobile Driving;Behavior;Binding;Bioinformatics;Biological Markers;biomarker identification;cancer cell;candidate identification;candidate marker;Career Mobility;Cell Communication;Cell Culture Techniques;Cell Line;Cell Lineage;cell motility;Cell Physiology;Cells;chemical carcinogenesis;collaborative environment;Communication;Complex;Data;Data Set;Development;Diagnosis;Disease;Disease Progression;Drug resistance;Early Diagnosis;Environment;Environmental Risk Factor;Epithelial Cells;epithelial to mesenchymal transition;Epithelium;Etiology;Evolution;Exhibits;experimental study;extracellular;Extracellular Matrix;Fibroblasts;Focal Adhesions;Follistatin;Fostering;Genes;Genetic;Genetic Transcription;Genome;Glycoproteins;Goals;Growth;Head and Neck Cancer;Human;Human Papillomavirus;Immune;Immune Evasion;Immunohistochemistry;In Vitro;insight;interdisciplinary approach;Invaded;Investigation;knock-down;knockout animal;Knowledge;Laboratories;Leadership;Link;loss of function;Malignant Epithelial Cell;malignant mouth neoplasm;Malignant Neoplasms;Measurement;Mediating;Mediator;member;migration;Modeling;Molecular;mouse model;Mouth Neoplasms;mouth squamous cell carcinoma;Mucous Membrane;Mus;Nature;Neoplasm Metastasis;neoplastic cell;new therapeutic target;Nitroquinolines;novel;Oncogenic;Oral;oral cavity epithelium;Oral mucous membrane structure;overexpression;Oxides;Pathway interactions;patient prognosis;patient stratification;Patients;Population;Pre-Clinical Model;Prognostic Marker;programs;Proliferating;Property;Protocols documentation;Quality of life;recruit;Regulation;Resolution;Resources;response;Role;Sampling;Signal Transduction;single-cell RNA sequencing;skills;Source;Squamous Cell;Squamous Epithelium;Stromal Cells;Supporting Cell;survival outcome;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;tobacco abuse;Training;transcription regulatory network;transcriptomics;Transforming Growth Factor beta;treatment response;treatment strategy;tumor;tumor growth;tumor initiation;tumor microenvironment;tumor progression;Tumor Promotion;tumorigenesis;Universities;Writing

PROJECT_TITLE: Single-cell profiling of Follistatin within the Tumor Landscape of Oral Squamous Cell Carcinoma

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (18)]


ADMINISTERING_IC: EY

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Aging;Bioengineering;Clinical Research;Data Science;Eye Disease and Disorders of Vision;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences;Patient Safety

ORG_CITY: LA JOLLA

ORG_DEPT: OPHTHALMOLOGY

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: NARRATIVE Innovations in artificial intelligence (AI) algorithms have exponentially increased with the widespread digitization of healthcare data in general and ophthalmic data in particular, but the implementation of AI-based technologies into clinical ophthalmic practice for clinical decision support is still in relatively early stages. This study will leverage data from diverse research and clinical glaucoma populations to develop deep learning algorithms to predict 1) patients who will need glaucoma surgery and 2) patients who are progressing in the next 12 months, and 2 years. These algorithms can then be used to support randomized clinical trial testing of AI guided glaucoma management using the AI models developed.

PI_NAMEs: BAXTER, SALLY LIU;CHRISTOPHER, MARK ;ZANGWILL, LINDA M (contact)

PROGRAM_OFFICER_NAME: GOVER, TONY DOUGLAS

PROJECT_TERMS: Address;African ancestry;Algorithms;Artificial Intelligence;artificial intelligence algorithm;artificial intelligence model;Clinical;clinical decision support;clinical practice;cloud based;cohort;Cornea;Data;deep learning;deep learning algorithm;deep learning model;design;Diagnostic;diverse data;Electronic Health Record;Enrollment;Evaluation Studies;Family;Funding;Future;Glaucoma;glaucoma surgery;Healthcare;Image;Infrastructure;innovation;model development;Modeling;multimodality;National Eye Institute;Operative Surgical Procedures;Ophthalmology;Optic Disk;Optical Coherence Tomography;Patients;Physiologic Intraocular Pressure;Population;randomized, clinical trials;Research;Technology;Testing;Thick;Time;Training;Update;Visual Fields

PROJECT_TITLE: Multimodal Artificial Intelligence to Predict Glaucomatous Progression and Surgical Intervention

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(95)-S]


ADMINISTERING_IC: FD

IC_NAME: FOOD AND DRUG ADMINISTRATION

ORG_CITY: NEW YORK

ORG_NAME: SLOAN-KETTERING INST CAN RESEARCH

PHR: Project Narrative Children and adults with rare cancers such as rhabdoid and desmoplastic small round cell tumors have dismal outcomes with current therapy. The planned research project is relevant to public health because the development of comprehensive proteogenomic methods and elucidation of tumor-specific cell surface proteomes will provide candidates for new targeted therapies. The proposed research is highly relevant to the NIH and FDA mission and the urgent unmet need of defining therapeutic targets for rare tumors, thereby overcoming fundamental barriers towards the development of improved treatments for human cancer.

PI_NAMEs: KENTSIS, ALEX  (contact);MCPHERSON, ANDREW WILLIAM

PROGRAM_OFFICER_NAME: ZINN, REBEKAH

PROJECT_TITLE: Integrative proteogenomics for elucidation of tumor-specific cell surface proteomes in ultra-rare cancers

STUDY_SECTION_NAME: Special Emphasis Panel[ZFD1 CFSN-T (01)]


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

ORG_CITY: Nashville

ORG_DEPT: PHYSIOLOGY

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Developmental stuttering affects 5% of children and 1% of adults worldwide, and exhibits a sibling relative risk of 70%; however, despite this high population prevalence and remarkably high heritability, understanding of the molecular and neurological function of genes impacting stuttering risk is lacking. The present application proposes to enhance our understanding of how common and rare genetic factors contribute to stuttering by using information about how genes are transcribed and how gene transcription affects brain features. This study represents the largest and most comprehensive functional genetic analysis of stuttering ever performed and the results obtained in this study will be critical to improving basic understanding of the mechanisms that contribute to risk, providing a foundational first step for future studies and therapeutic strategies.

PI_NAMEs: SCARTOZZI, ALYSSA  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: adolescent health;Adult;Affect;Age;biobank;Biological;Brain;Brain imaging;cell type;Child;Chromosome Mapping;Clinical;Clinical Data;Code;cohort;Communication;Complex;Computer Models;Data;Data Set;Data Sources;Development;Developmental Stuttering;Disease;Disfluent;diverse data;endophenotype;Environmental Exposure;Etiology;Exhibits;exome;Family;Future;Gene Expression;Gene Expression Regulation;gene expression variation;gene function;Genes;Genetic;genetic analysis;genetic architecture;Genetic Enhancer Element;genetic linkage analysis;genetic pedigree;Genetic Predisposition to Disease;genetic risk factor;Genetic Transcription;Genetic Variation;genome wide association study;genome-wide;Genomics;Genotype;Heritability;improved;Individual;innovation;insight;International;Joints;Literature;Maps;Measures;Meta-Analysis;Methods;Modeling;Molecular;Nervous System Physiology;neural;neuroimaging;Neurologic;neuromechanism;neuromuscular;novel;Participant;Patient Self-Report;Pattern;Persons;Phenotype;polygenic risk score;Population;precision medicine;predictive modeling;Prevalence;Promoter Regions;Quantitative Trait Loci;rare variant;Regulation;Regulatory Element;Relative Risks;Risk;Risk Adjustment;RNA;Role;Sampling;sex;Siblings;Single Nucleotide Polymorphism;sound;Speech Disorders;Speech Sound;statistics;Stuttering;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Tissues;tool;trait;transcriptome;transmission process;Twin Multiple Birth;Untranslated RNA;Variant;verbal;Work

PROJECT_TITLE: Functional characterizations of the genetic etiology of stuttering

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Antimicrobial Resistance;Clinical Research;Comparative Effectiveness Research;Contraception/Reproduction;Infectious Diseases;Maternal Health;Maternal Morbidity and Mortality;Patient Safety;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn;Prevention;Urologic Diseases;Women's Health Research

ORG_CITY: SAINT LOUIS

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE Urinary tract infections (UTIs) are common during pregnancy and can cause serious maternal and neonatal consequences, but current clinical guidelines fail to provide guidance for first trimester management of UTI due to uncertainty about the relative benefits and harms of commonly used antibiotic regimens. Our proposed study will evaluate the utilization, effectiveness, and safety of commonly-used antibiotic regimens in pregnant women treated for outpatient UTI. Ultimately, the evidence generated by this study will inform clinical guidelines and antibiotic prescribing, which will lead to better outcomes in pregnant women and infants, improved antimicrobial stewardship, and improved long-term bacterial susceptibility to antibiotics.

PI_NAMEs: BUTLER, ANNE MOBLEY (contact)

PROGRAM_OFFICER_NAME: FABIYI, CAMILLE

PROJECT_TERMS: Address;administrative database;Adverse drug event;Adverse event;Affect;Ambulatory Care;American College of Obstetricians and Gynecologists;anti-microbial drug;Anti-microbial susceptibility;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;antimicrobial;Antimicrobial Resistance;Bacteriuria;Benefits and Risks;beta-Lactams;Calendar;Cardiac;Clinical;clinical decision-making;Clinical Trials;Clostridium difficile;comparative safety;Congenital Abnormality;cost efficient;Data;Databases;Diarrhea;early pregnancy;Effectiveness;effectiveness analysis;Electronic Health Record;epidemiology study;Evaluation;Exanthema;Exclusion;First Pregnancy Trimester;follow-up;Geographic Locations;Gestational Age;Guidelines;Healthcare Systems;Hypersensitivity;improved;Infant;insight;kidney infection;Knowledge;Low Birth Weight Infant;Microbiology;microbiome;Modernization;Neonatal;Nitrofurantoin;Obesity;Observational Study;optimal treatments;oral cleft;Outcome;Outpatients;pathogen;Patients;Pattern;perinatal complications;perinatal outcomes;Pharmaceutical Preparations;Population Heterogeneity;Predisposition;Pregnancy;pregnant;Pregnant Women;Premature Birth;Premature Labor;prevent;prospective;randomized trial;randomized, clinical trials;Recommendation;Recording of previous events;Regimen;Research Design;Risk;Risk Estimate;Safety;Sample Size;screening guidelines;Second Pregnancy Trimester;Sepsis;Smoking Status;standard care;standard of care;stillbirth;Sulfonamides;Teratogens;Third Pregnancy Trimester;Time;treatment duration;Treatment Failure;Treatment Protocols;treatment risk;Uncertainty;urinary;Urinary tract infection;Uropathogen;Variant;Woman;women's treatment

PROJECT_TITLE: Identifying Optimal Antibiotic Regimens to Treat Urinary Tract Infections During Pregnancy

STUDY_SECTION: HSQE

STUDY_SECTION_NAME: Health Services: Quality and Effectiveness Study Section[HSQE]


NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Caregiving Research;Clinical Research;Depression;HIV/AIDS;Infectious Diseases;Mental Health;Pediatric;Pediatric - AIDS;Prevention

PHR: NARRATIVE There is a rapidly growing population of over 16 million children who are HIV-exposed uninfected (HEU) under the age of 14 years, and substantial investments have been made to evaluate the impact of in utero HIV and antiretroviral (ARV) drug exposures on the health and developmental outcomes among children who are HEU throughout infancy, childhood, and adolescence. While it is equally of public health importance to follow outcomes of young adults with in utero HIV- and ARV drug-exposures, young adults must be made aware of their exposure status, necessitating parent disclosure, which can be challenging. The Disclosure Intervention to Support Caregivers (DISC) study will result in the development of a contextually appropriate tool to prepare caregivers living with HIV to disclose their HIV status to their adolescents and equip caregivers to assess the wellbeing of their adolescents during and following disclosure.

PI_NAMEs: JAO, JENNIFER ;MAKHEMA, JOSEPH MOEKETSI;POWIS, KATHLEEN  (contact)

PROGRAM_OFFICER_NAME: ESBER, ALLAHNA LAUREN

PROJECT_TERMS: 10 year old;14 year old;Administrative Supplement;Adolescence;Adolescent;adolescent health;Adult;Affect;Africa South of the Sahara;Age;Anti-Retroviral Agents;antiretroviral therapy;Anxiety;Awareness;Biological Factors;Botswana;Breast Feeding;cancer risk;cardiometabolism;Cardiovascular Diseases;cardiovascular risk factor;caregiver depression;Caregiver support;Caregivers;Child;child depression;Childhood;Clinical Trials;Data;design;Development;Disclosure;Disparity;Drug Exposure;early onset;Educational workshop;Epidemic;experience;Exposure to;Focus Groups;follow-up;Grant;Growth;Health;health assessment;High Prevalence;high risk;HIV;Household;Human;improved;in utero;Incidence;Individual;infancy;insulin sensitivity;Intervention;Interview;Investments;Lamivudine;Life;Lopinavir;Low Prevalence;Mental Depression;Mental Health;Methods;Morbidity - disease rate;mortality;Neonatal;Nevirapine;Newborn Infant;Non-Insulin-Dependent Diabetes Mellitus;Observational Study;Outcome;Parents;Personal Satisfaction;Persons;Pharmaceutical Preparations;Population;Pregnancy;pregnant;prenatal exposure;Prevalence;Principal Investigator;Prophylactic treatment;prospective;Psychosocial Factor;Public Health;Reporting;Reproductive Health;Research;Research Design;Research Methodology;Resources;Risk;Ritonavir;scale up;skills;social stigma;Source;Stress;structural determinants;support tools;Testing;Time;tool;transmission process;Treatment outcome;Uncertainty;Vertical Transmission;Viral;Viral Load result;Work;young adult;Zidovudine

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(50)-R]


ADMINISTERING_IC: HL

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Bioengineering;Regenerative Medicine

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

ORG_STATE: PA

PHR: Project Narrative The proposed research is relevant to public health and aims at understanding how coordinated approaches can be used to rapidly guide microvascular development. This will enable new and translatable reconstructive approaches for tissue loss, and broadly advance regenerative medicine.

PI_NAMEs: RAVNIC, DINO J;SHEIKHI, AMIR  (contact)

PROGRAM_OFFICER_NAME: THAKAR, RAHUL GAUTAM

PROJECT_TITLE: Manipulation of Host Tissue to Induce a Hierarchical Microvasculature

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_NAME: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

PHR: Narrative Persons with HIV have an increased risk of Clonal hematopoiesis of Indeterminate Potential (CHIP) which is the presence of a proportion of blood cells carrying a somatic mutation that have all arisen from a common blood stem or progenitor cell. CHIP is hypothesized to be a biomarker of accelerated aging and may increase an individual’s risk for developing cancer. In this study, we will evaluate the prevalence of CHIP and methylation markers in PWH and their potential association with cancer.

PI_NAMEs: PARSONS, RAMON E (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Age;age acceleration;Age related comorbidities;age-related disease;Aging;aging biomarker;aging population;aging process;AIDS related cancer;Algorithms;antiretroviral therapy;Automobile Driving;Behavioral;biological age;Biological Markers;Blood Cells;Bone Marrow;cancer risk;Cardiovascular Diseases;Cells;Characteristics;Chronic;Chronology;Clinical;cohort;Cohort Studies;Complex;Data;Disease;DNA Library;DNA Methylation;DNA Sequence Alteration;Epigenetic age;epigenetic clock;Epigenetic Process;Event;Exhibits;exome sequencing;experience;General Population;Genotype;Growth;Health system;Hematologic Neoplasms;Hematopoiesis;Hematopoietic;Hematopoietic stem cells;High Prevalence;high risk;HIV;HIV Infections;Immune;immune activation;Incidence;Individual;Inferior;Inflammaging;Inflammation;Inflammatory;interest;Link;Malignant Neoplasms;Measures;Mediating;Mediator;Methylation;methylation biomarker;methylation pattern;molecular clock;Morbidity - disease rate;mortality;Mutate;Mutation;Non-Hematologic Malignancy;novel marker;Outcome;Participant;Patients;Persons;Phenotype;Population;Pre-Clinical Model;Prevalence;preventive intervention;Process;Prognostic Marker;Risk;Risk Factors;Role;Smoking;Solid;Somatic Mutation;Specimen;stem cells;tumor microenvironment;Tumor-infiltrating immune cells;United States;Veterans;Work

PROJECT_TITLE: Clonal Hematopoeisis, Biomarkers of Aging and Cancer Risk for People Living With HIV (HIV-Associated Cancers in Aging Populations)

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Cancer Centers Study Section (A)[NCI-A]


NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;Dissemination and Implementation Research;Mental Health;Pediatric

ORG_CITY: CHICAGO

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: NORTHWESTERN UNIVERSITY AT CHICAGO

ORG_STATE: IL

PHR: Project Narrative. Youth commonly seek help for their mental health concerns in schools, but many schools don’t have enough mental health providers to help everyone in need. Research studies show that digital, self-guided, single-session interventions can help reduce students’ mental health concerns, but we don’t know how to get schools to use these kinds of interventions in real life outside of research studies. In this study, we will work together with students, parents/caregivers, teachers, administrators, and school mental health providers to find out the best ways that digital, self-guided, single session interventions can be practically implemented in schools.

PI_NAMEs: COHEN, KATHERINE  (contact)

PROGRAM_OFFICER_NAME: SIMS, BELINDA ENITA

PROJECT_TERMS: Address;Administrator;Adoption;Anxiety;Attention;career;Caregivers;Clinical;Clinical effectiveness;Communities;Consolidated Framework for Implementation Research;cost;Data Analyses;Data Collection;design;Development;Diagnostic;digital;digital delivery;Disease;dosage;effectiveness testing;Environment;evidence base;Evidence based intervention;exhaust;experience;Feeling hopeless;Focus Groups;Funding;Future;Goals;Health Personnel;help-seeking behavior;High School Student;human centered design;implementation barriers;implementation framework;implementation science;implementation strategy;improved;Infrastructure;innovation;interest;Intervention;intervention program;K-Series Research Career Programs;Learning;Life;member;Mental Depression;Mental disorders;Mental Health;Mental Health Services;Mentorship;Meta-Analysis;Methods;Modeling;National Institute of Mental Health;Parents;Play;post intervention;Productivity;programs;Public Health;Research;research study;Resources;Role;School Health Services;Schools;Scientist;Self Administration;Services;skills;Strategic Planning;Structure;Students;Symptoms;System;teacher;Time;Training;Translating;Universities;uptake;Work;Youth

PROJECT_TITLE: Advancing Implementation of Single Session Interventions in Schools

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F16-T (20)]


NIH_SPENDING_CATS: Cancer;Dental, Oral, and Craniofacial Disease;Immunotherapy;Lymphatic Research;Rare Diseases

ORG_CITY: Aurora

ORG_NAME: UNIVERSITY OF COLORADO DENVER

ORG_STATE: CO

PHR: Narrative Head and neck squamous cell carcinoma (HNSCC) exhibits a proclivity for regional recurrence in the tumor draining lymph nodes (tDLNs) well after clearance of the primary tumor. This pattern of spread is highlighted by decreased lymphocyte trafficking and de-differentiated Lymphotoxin Beta receptor (LtBR) expressing High Endothelial Venules (HEVs) within the tDLN. We aim to decipher how regional recurrence is promoted in the absence of LtBR signaling, and whether LtBR agonism restores HEV functionality to mitigate regional recurrence.

PI_NAMEs: OLIMPO, NICHOLAS A (contact)

PROJECT_TERMS: Ablation;Adoptive Transfer;Agonist;antagonist;Antigen Presentation;antigen-specific T cells;Biological;Blood;Blood Vessels;cancer cell;CD8-Positive T-Lymphocytes;Cells;Clinical;Coculture Techniques;cytotoxicity;Data;Dendritic Cells;Development;Disease;Distant Metastasis;draining lymph node;Equilibrium;Exhibits;experimental study;functional loss;functional restoration;gain of function;Genetic Engineering;Head and Neck Squamous Cell Carcinoma;High Endothelial Venule;I-kappa B Proteins;Immune;Immunity;Immunofluorescence Immunologic;Immunosuppression;In Vitro;in vivo;Interleukin-10;irradiation;loss of function;lymph nodes;Lymphatic;Lymphocyte;Lymphocyte antigen;Lymphocyte Count;lymphocyte trafficking;lymphotoxin beta receptor;Maintenance;Measures;migration;Modeling;mouse model;Mus;Neck Dissection;Neoplasm Metastasis;Nodal;Pattern;pharmacologic;postcapillary venule;prevent;Primary Neoplasm;Radiation;Radiation therapy;Receptor Signaling;Recurrence;Recurrent disease;Regulation;Regulatory T-Lymphocyte;Role;Signal Transduction;Site;Structure;System;Therapeutic;trafficking;transcriptome sequencing;translational approach;tumor;tumor progression

PROJECT_TITLE: Targeting the Regulation of High Endothelial Venules in HNSCC Regional Recurrence


NIH_SPENDING_CATS: Brain Disorders;Genetics;Intellectual and Developmental Disabilities (IDD);Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurosciences;Orphan Drug;Pediatric;Rare Diseases;Rett Syndrome;Women's Health Research

ORG_CITY: HOUSTON

ORG_DEPT: GENETICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: Project Narrative Artificial intelligence has been used to identify successful therapeutics for monogenic neurodevelopmental disorders (NDDs), but a stable, generalizable prediction method has not been established. I hypothesize that deriving treatment predictions directly from raw scientific data without any human intervention will allow us to prioritize the most likely drugs to modulate specific genes. I will test this hypothesis by validating putative regulators of methyl-CpG-binding protein 2 (MeCP2) in vitro, and computationally assess our ability to dissect the druggable pathways downstream of a gene product.

PI_NAMEs: DEISSEROTH, COLE  (contact)

PROGRAM_OFFICER_NAME: PARISI, MELISSA

PROJECT_TERMS: Affect;Artificial Intelligence;Benchmarking;Biochemical Reaction;Cells;Chemicals;Childhood;Cognitive;Data;Databases;Defect;Development;Disease;dosage;drug action;Drug Targeting;experimental study;Gene Cluster;gene correction;Gene Expression;Gene Expression Profiling;gene function;gene product;Genes;Genetic;Genetic Transcription;Grouping;Human;improved;in silico;In Vitro;Individual;Induced pluripotent stem cell derived neurons;infancy;interest;Intervention;knock-down;knockout gene;Knowledge;Link;Literature;Manuals;MeCP2 Duplication Syndrome;Metadata;Methods;Methyl-CpG-Binding Protein 2;Molecular;Motor;Natural Language Processing;Neurodevelopmental Disorder;Neurons;novel;Pathogenicity;Pathway Analysis;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Prediction of Response to Therapy;protein function;Proteins;Regulator Genes;Reporting;Resources;Rett Syndrome;Role;screening;success;Symptoms;Techniques;Testing;Therapeutic;Time;tool;transcriptome;transcriptome sequencing;transcriptomics;Western Blotting

PROJECT_TITLE: Identifying potential therapeutics for neurodevelopmental disorders using artificial intelligence and transcriptional data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F05-D (21)]


NIH_SPENDING_CATS: Aging;Cancer;Clinical Research;Genetics;HIV/AIDS;Hematology;Infectious Diseases;Rare Diseases;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stem Cell Research - Nonembryonic - Non-Human

PHR: The population of people living with HIV (PLWH) is aging due to the improvement in life expectancy brought by anti-retroviral therapies (ART), unveiling the increased risk that PLWH have for developing cancers that are not typically associated with HIV infection. Clonal hematopoiesis (CH) is an age-related phenomenon in which we accrue somatic mosaicism in the blood system, increasing the risk of hematologic malignancies. Given that HIV infection increases the risk of developing CH, the objective of this project is to determine whether HIV infection promotes CH and its transformation to hematologic malignancies.

PI_NAMEs: NAKADA, DAISUKE ;REDDY, PAVAN  (contact)

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Acute Myelocytic Leukemia;Age;age effect;age related;Aging;AIDS related cancer;AML/MDS;antiretroviral therapy;Attenuated;Biological Assay;Blood;Bone Marrow Transplantation;Cell Physiology;cell type;Cells;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;cytokine;Deceleration;Development;DNMT3a;Dysmyelopoietic Syndromes;Elderly;Exhibits;experimental study;Genes;genetic regulatory protein;Genetic Transcription;Hematologic Neoplasms;Hematopoiesis;hematopoietic stem cell expansion;Hematopoietic stem cells;high risk;HIV;HIV Genome;HIV Infections;HIV Seronegativity;HIV-1;Human;Immune;improved;Incidence;Inflammation;inhibitor;insight;Intervention;Length;Life Expectancy;Life Extension;Malignant - descriptor;Malignant Neoplasms;Modeling;Molecular;Monitor;Mosaicism;mouse model;Mus;mutant;Mutant Strains Mice;Mutate;Mutation;Myeloproliferative disease;Non-Hodgkin's Lymphoma;novel;Patients;Persons;Population;Precancerous Conditions;pressure;Prevalence;Prognosis;Proteins;Research;Resistance;Risk;Risk Assessment;Role;RUNX1 gene;Sampling;stem cell function;Structural Protein;System;Testing;Texas;Tissues;transcriptome;Transplantation;vif Gene Products;Viral Load result

PROJECT_TITLE: The role of HIV Vif in clonal hematopoiesis and malignant transformation (HIV-Associated Cancers in Aging Populations)


NIH_SPENDING_CATS: Bioengineering;Biomedical Imaging;Cancer;Clinical Research;HIV/AIDS;Infectious Diseases;Lung;Lung Cancer;Machine Learning and Artificial Intelligence;Prevention

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

PI_NAMEs: PARK, BEN HO (contact)

PROGRAM_OFFICER_NAME: ROBERSON, SONYA

PROJECT_TERMS: Adult;Age;AIDS related cancer;Algorithm Design;antiretroviral therapy;artificial intelligence model;Biological Markers;biomarker panel;Blood;blood-based biomarker;Body Composition;Body mass index;CA-125 Antigen;Cancer Detection;cancer diagnosis;Cancer Etiology;cancer risk;Caring;Clinical;cohort;comorbidity;Data;Data Set;deep learning model;Diagnosis;Disease;Early Detection Research Network;Early Diagnosis;Effectiveness;effectiveness evaluation;Eligibility Determination;Ensure;Evaluation;experience;FDA approved;General Population;high risk population;HIV;Image;improved;Incidence;Individual;innovation;Life Expectancy;low dose computed tomography;Lung;lung cancer screening;Machine Learning;machine learning algorithm;Malignant neoplasm of lung;Malignant Neoplasms;Medical Imaging;Methods;Modeling;mortality;mortality risk;Nodule;novel;outcome prediction;patient population;Patients;Performance;Persons;Population;Population Heterogeneity;predictive modeling;Proteins;Qualifying;radiomics;Research;response;Risk;risk prediction;risk prediction model;Running;Scanning;screening;screening program;Sensitivity and Specificity;Smoke;Smoking;Smoking History;smoking prevalence;Source;Time;Tobacco use;Training;Unnecessary Procedures;Validation;X-Ray Computed Tomography

PROJECT_TITLE: Evaluation of Radiomic and Blood-Based Biomarkers for the Early Detection of Lung Cancer in People Living with HIV (Biospecimen/Cohort)


ADMINISTERING_IC: EB

FUNDING_MECHANISM: SBIR-STTR RPGS

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Behavioral and Social Science;Bioengineering;Brain Disorders;Depression;Mental Health;Mental Illness;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: OXFORD

ORG_NAME: INTERVAL THERAPEUTICS LLC

ORG_STATE: MS

PHR: Project Narrative The current proposal will move a new treatment paradigm for opioid use disorder (OUD) closer to clinical reality. Biodegradable implants capable of delivering psychedelic microdoses on an interval schedule will be developed and tested. Success of the proposal will lead to a disruptive new technology for long-term maintenance of mood disorders that accompany OUD.

PI_NAMEs: HEATH, KATIE ;WALKER, GLENN MADISON;WERFEL, THOMAS A (contact)

PROGRAM_OFFICER_NAME: ASHMONT, KARI RICH

PROJECT_TERMS: Absorbable Implants;absorption;Acetates;addiction;Address;Agonist;alternative treatment;Animal Model;Anxiety;Biological Assay;biomaterial compatibility;Brain;caprolactone;Categories;Cell Line;Cellulose;Clinical;clinical investigation;Clinical Research;Clinical Trials;clinically relevant;commercialization;cost;craving;cyanine dye 5;depression model;depressive symptoms;Devices;Dorsal;Dose;Drug Kinetics;Economic Burden;efficacy testing;Fluorescent Dyes;Fostering;Future;Goals;Grant;Growth;Hallucinogens;Head;Healthcare Systems;High Pressure Liquid Chromatography;Implant;improved;In Vitro;in vivo;Individual;Ingestion;innovation;Licensing;Lysergic Acid Diethylamide;Maintenance;manufacture;Measures;Medical;Medical Care Costs;Mental Depression;Mental disorders;Methods;microdevice;Microfluidics;Modality;Monitor;Mood Disorders;Moods;Mus;new technology;non-invasive optical imaging;Occupational;opioid epidemic;opioid overdose;opioid use disorder;opioid withdrawal;overdose death;Patients;Penetrance;Pharmaceutical Preparations;Pharmacologic Substance;Phase;phase 2 study;phthalates;Placebo Effect;Placebos;Plasma;Pluronics;Polymers;Positioning Attribute;pre-Investigational New Drug meeting;preclinical study;Production;programs;Psilocybin;psychologic;reduce symptoms;Regimen;Relapse;Reporter;Reporting;Research;response;Rodent Model;Schedule;Series;Small Business Innovation Research Grant;Small Business Technology Transfer Research;social;subcutaneous;success;Surface;Symptoms;Technology;technology platform;Testing;Therapeutic;Time;treatment-resistant depression;United States;Withdrawal

PROJECT_TITLE: Microdosing Implant to Mitigate Depression Associated with Opioid Use Disorder

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 BBBT-F (10)]


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Genetics

ORG_CITY: PHILADELPHIA

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: Emerging evidence from recent genome-wide studies has revealed that promoters across eukaryotes are commonly paired to drive bidirectional transcription. Work in yeast suggests bidirectional transcription could be the naïve or innate state of transcription initiation with directionality evolving due to the action of diverse pathways. Building on our initial success in developing a highly efficient in vitro reconstitution system of transcription initiation from highly purified yeast factors, we set out to further develop this system to solve the mechanism of divergent transcription through structural and biochemical dissection.

PI_NAMEs: MURAKAMI, KENJI  (contact)

PROGRAM_OFFICER_NAME: WAIRKAR, YOGESH PRABHAKAR

PROJECT_TERMS: analytical ultracentrifugation;Base Pairing;Biochemical;Chemicals;Complex;crosslink;Cryo-electron tomography;Cryoelectron Microscopy;Dependence;dimer;Dimerization;Dissection;Dissociation;DNA;Elongation Factor;Employment;Eukaryota;Evolution;Funding;Gene Expression;Genes;genetic regulatory protein;Genetic study;Genetic Transcription;genome-wide analysis;Human;Impairment;In Vitro;in vivo;insight;Length;Mass Spectrum Analysis;Mediator;Modeling;Molecular;Molecular Conformation;mutant;novel;Nucleosomes;particle;Pathway interactions;Phosphotransferases;Polymerase;Positioning Attribute;promoter;Property;Proteins;reconstitution;recruit;Research;RNA;RNA Polymerase II;Role;Sedimentation process;Series;stoichiometry;Structure;success;System;Tail;Transcript;transcription factor;transcription factor TFIIH;Transcription Initiation;Transcriptional Activation;Transcriptional Regulation;transcriptome sequencing;Work;Yeasts

PROJECT_TITLE: Functional and structural studies of the transition from transcription initiation to elongation

STUDY_SECTION: MSFB

STUDY_SECTION_NAME: Macromolecular Structure and Function B Study Section[MSFB]


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Cancer;Cervical Cancer;Clinical Research;Clinical Trials and Supportive Activities;HIV/AIDS;Infectious Diseases;Radiation Oncology;Women's Health Research

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: Project Narrative The proposed project is relevant to public health because it develops a scalable tool that will help bring high- quality treatment planning to clinics that treat women living with HIV for cervical cancer where none existed previously. Thus, the proposed project is relevant to the part of the NIH’s mission to advance scientific knowledge and help people live longer, healthier lives.

PI_NAMEs: DRAETTA, GIULIO FRANCESCO (contact)

PROJECT_TERMS: Acute;Affect;automated treatment planning;Benign;Bladder;bone;Bone Marrow;Cancer Hospital;cancer radiation therapy;Cervical;Cervix Uteri;chemoradiation;Clinic;Clinical;Clinical Research;cohort;cost;Country;Data;Data Set;deep learning model;design;Development;Disease;Disproportionately impacts women;Dose;Eligibility Determination;FDA approved;Funding;Future;Goals;Health Services Accessibility;Hematology;Histologic;HIV;HIV Infections;Hospitals;Human Papillomavirus;Image;immunological status;improved;Incidence;Individual;Infrastructure;Institutional Review Boards;Ionizing radiation;Knowledge;Life;life span;Location;Longitudinal cohort;low and middle-income countries;lymph nodes;lymphadenopathy;Malignant - descriptor;Malignant neoplasm of cervix uteri;Malignant Neoplasms;Manuals;Marrow;Methods;Mission;Modeling;Nodal;Normal tissue morphology;Organ;Outcome;Outcomes Research;Paraaortic;participant enrollment;Patients;Pelvic lymph node group;Pelvis;Performance;Persons;Planning Techniques;Play;Prevalence;prospective;Public Health;Radiation;Radiation Dose Unit;Radiation therapy;Rectum;Reporting;Research;Research Personnel;Resources;Risk;Role;scale up;Scientific Advances and Accomplishments;Services;soft tissue;Structure;Techniques;Testing;tool;Toxic effect;Translating;treatment planning;Treatment-related toxicity;United States National Institutes of Health;Uterus;Validation;Woman;Women's cohort;women's outcomes;Women's study;women's treatment;Work;X-Ray Computed Tomography;Zambia

PROJECT_TITLE: Developing Automated tools for Cervical Cancer Radiotherapy Treatment for Zambian Women living with HIV (Biospecimen/Cohort)


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Gene Therapy;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Pediatric

PHR: PROJECT NARRATIVE MYT1L syndrome is a recently identified, understudied neurodevelopmental disorder caused by loss of one copy of the MYT1L gene . Antisense oligonucleotides (ASOs) are a class of molecules that have been safely used in the clinic to treat neurological disorders by changing gene regulation for disease genes like MYT1L. This project will explore MYT1L gene regulation and its potential to be harnessed for ASO-based treatments.

PI_NAMEs: GACHECHILADZE, MARIAM ALEXANDRA (contact)

PROGRAM_OFFICER_NAME: PINARD, COURTNEY ROSE

PROJECT_TERMS: 3' Untranslated Regions;Affect;Alleles;Animal Behavior;Antisense Oligonucleotides;Attention deficit hyperactivity disorder;autism spectrum disorder;Behavioral;behavioral phenotyping;Binding;Bioinformatics;Biological Assay;career;cell type;Cells;Central Nervous System;Central Nervous System Diseases;Clinic;Clinical;clinically relevant;comorbidity;Complementary RNA;Data;Disease;Dose;efficacy testing;Elements;Family;FDA approved;flexibility;Future;Gene Expression Regulation;gene therapy;Genes;Genetic;Genomics;global developmental delay;Goals;Heterozygote;Human;immunogenicity;in vivo;Induced pluripotent stem cell derived neurons;insight;Intellectual functioning disability;Investigation;Language Development;loss of function mutation;Loss of Heterozygosity;Measures;Messenger RNA;Methyl-CpG-Binding Protein 2;MicroRNAs;Molecular;Motor;mRNA Expression;mRNA Stability;Mus;Muscle hypotonia;mutant;Mutation;Nervous System Disorder;Neurodevelopmental Disorder;neurogenetics;Neurons;Obesity;Patients;Phenotype;Physicians;Post-Transcriptional Regulation;posttranscriptional;preclinical study;Prevalence;Production;Property;Protein Biosynthesis;protein expression;protein function;Proteins;Regulation;Regulatory Element;Reporter;Response Elements;restoration;RNA Splicing;RNA-Binding Proteins;Role;Safety;Scientist;screening;Site;Syndrome;synthetic nucleotide;Testing;Therapeutic;therapeutic RNA;Titrations;tool;Training;Transcript;transcription factor;transcriptomics;Translational Repression;translational therapeutics;Translations;Untranslated Regions;Untranslated RNA;Up-Regulation

PROJECT_TITLE: Antisense oligonucleotide-based upregulation of neurodevelopmental disorder gene MYT1L

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F03A-E (20)]


ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Eye Disease and Disorders of Vision;Mental Health;Microbiome;Neurosciences

ORG_CITY: RENO

ORG_DEPT: BIOLOGY

ORG_NAME: UNIVERSITY OF NEVADA RENO

ORG_STATE: NV

PHR: Program Director/Principal Investigator (Last, First, Middle): HOY, JENNIFER, LYN PROJECT NARRATIVE This work will identify neural circuit mechanisms underlying the development of visual stimulus detection and pursuit behavior. Appropriately orienting towards salient stimuli and filtering out distraction is required for healthy visual cognition and attention in adults and is sensitive to developmental experience. Autism, schizophrenia, ADHD and generalized anxiety are disorders rooted in perturbed development and are associated with deficits in the ability to properly modulate visuospatial orienting behavior.

PI_NAMEs: HOY, JENNIFER LYN (contact)

PROGRAM_OFFICER_NAME: FLANDERS, MARTHA C

PROJECT_TERMS: Address;Adult;Animals;approach behavior;Area;Attention Deficit Disorder;Attention deficit hyperactivity disorder;attentional control;autism spectrum disorder;Behavior;behavior change;Behavioral;behavioral outcome;Biomedical Research;Calcium;career development;Cell Physiology;cell type;Cells;Cues;Data;density;Detection;Development;Developmental Process;Disease;distraction;doctoral student;Electrophysiology (science);Emotional;Environment;Ethology;Etiology;excitatory neuron;experience;Failure;Future;Gene Expression;Generalized Anxiety Disorder;Generations;Genetic;Germ-Free;Goals;habituation;Hispanic;host microbiome;Image;in vivo;inhibitory neuron;Insecta;insight;Interdisciplinary Study;Knowledge;Life;LYN gene;Mammals;Measures;Mediating;Mentors;Methods;microbial colonization;microbiome;microbiota;Microglia;Mus;National Research Service Awards;Nervous System;Nervous System Disorder;neural;neural circuit;Neurodevelopmental Disorder;Neurons;novel;Nucleotides;optogenetics;Organism;parent project;Parents;Pattern;Performance;Photic Stimulation;Post-Traumatic Stress Disorders;postnatal;Principal Investigator;Process;programs;Publishing;Research;Research Personnel;Rodent;Role;Schizophrenia;Sensory;Shapes;Space Perception;Stimulus;Structure;superior colliculus Corpora quadrigemina;Tadpoles;targeted treatment;tool;Training;transcriptome;transcriptome sequencing;transcriptomics;Ultrasonography;Underrepresented Students;Vertebrates;Virus;vision development;Visual;Visual attention;visual cognition;visual control;visual neuroscience;Visual Perception;visual plasticity;visual processing;visual stimulus;Visual System;Visuospatial;Work;Zebrafish

PROJECT_TITLE: Experience-Dependent Plasticity in Superior Colliculus and Natural Visual Behavior


ADMINISTERING_IC: AT

IC_NAME: NATIONAL CENTER FOR COMPLEMENTARY & INTEGRATIVE HEALTH

NIH_SPENDING_CATS: Behavioral and Social Science;Chronic Pain;Complementary and Integrative Health;Mental Health;Neurosciences;Pain Research;Prevention;Telehealth

ORG_CITY: Kirkland

ORG_NAME: 2MORROW, INC

ORG_STATE: WA

PHR: 2Morrow, Inc. CRP Grant Application – Narrative: Chronic pain affects 50M adults in the US, and there is a need for non-addictive treatment options. With an SBIR grant, 2Morrow developed a behavioral digital therapeutic for those living with chronic pain. In the current economy, 2Morrow must show both clinical and commercial traction in order to attract funding, M&A, or larger clients; however, we need an experienced commercial executive to lead, implement, and drive commercialization for this innovative intervention.

PI_NAMEs: MASTERSON, JO  (contact);WATERS, DEANNA

PROGRAM_OFFICER_NAME: HORGUSLUOGLU, EMRIN U

PROJECT_TERMS: Acceleration;Address;Adoption;Adult;Advisory Committees;Affect;Agreement;Analgesics;Anxiety;Anxiety Disorders;anxiety reduction;Applications Grants;Awareness;Behavior Therapy;Behavioral;behavioral health;Businesses;Caring;chronic pain;chronic pain management;chronic pain patient;Client;Clinical;Clinical Trials;commercialization;commercialization readiness;Communities;Complex;Coping Skills;cost;Country;design;Development;digital;digital health;digital treatment;Drug Prescriptions;Economic Burden;Education;Emotional;evidence base;Evidence based practice;expectation;experience;feasibility trial;Feedback;Feeling;Frustration;Funding;Goals;Grant;Guidelines;healing;Health behavior;Healthcare;Individual;Industry;innovation;Intervention;Investments;Lead;Leadership;Licensing;Life;Marketing;Medical;meetings;Mental Depression;Mental Health;Modeling;novel;opioid epidemic;Pain;Pain Free;Pain interference;Pain management;Participant;Patients;payment;Persons;Phase;Positioning Attribute;Process;programs;Provider;psychosocial;Randomized;Recommendation;Resources;Role;Sales;skill acquisition;Sleep;Small Business Innovation Research Grant;social stigma;Stress;System;Technology;Testing;Therapeutic;Time;timeline;Tobacco use;tool;Traction;Training;trend;Update;Weight;Wellness Program;Woman

PROJECT_TITLE: Commercialization of a Behavioral Digital Health Program for Individuals with Chronic Pain

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 MCST-B (19)]


ADMINISTERING_IC: AG

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences;Prevention;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LEXINGTON

ORG_NAME: MCM6 THERAPEUTICS, INC.

PHR: PROJECT NARRATIVE APOE4, the strongest genetic risk factor for late-onset Alzheimer’s disease, causes aberrant cholesterol and lipid accumulation in human glial cells. No therapeutics are available to treat central nervous system lipid dysfunction in APOE4 carriers, which could prevent or slow cognitive decline in this large subset of Alzheimer’s disease patients. MCM6 Therapeutics, in partnership with Dr. Joel Blanchard’s lab at the Icahn School of Medicine at Mt. Sinai, proposes to screen a diverse small molecule library to identify novel therapeutics that reduce cholesterol and lipid accumulation in APOE4 oligodendrocytes and restore neuron myelination.

PI_NAMEs: LAM, KELVIN T (contact)

PROGRAM_OFFICER_NAME: MARTIN, ZANE

PROJECT_TERMS: 3-Dimensional;Affect;Aftercare;aged;Algorithms;Alleles;Alzheimer's Disease;Alzheimer's disease patient;Alzheimer's disease risk;Amino Acids;Amyloid;Animal Model;apolipoprotein E-3;apolipoprotein E-4;Astrocytes;Autopsy;Behavioral Assay;Biological Assay;Biological Markers;Biology;BODIPY;Brain;brain tissue;BRCA1 gene;BRCA2 gene;Cell Line;cell type;Cells;Central Nervous System;Cholesterol;Cholesterol Homeostasis;cholesterol trafficking;Classical Niemann-Pick Disease;Clinical;Clustered Regularly Interspaced Short Palindromic Repeats;Coculture Techniques;cohort;Collaborations;comparison control;Cyclodextrins;Deposition;Dose;drug discovery;efficacy evaluation;efficacy validation;European ancestry;Evaluation;FDA approved;Functional disorder;Future;Genes;Genetic Risk;genetic risk factor;genetic variant;genome wide association study;Hippocampus;Histologic;Homeostasis;Human;humanized mouse;Image;Image Analysis;Impaired cognition;Impairment;improved;In Vitro;in vivo;Individual;induced pluripotent stem cell;innovation;Intracellular Accumulation of Lipids;Late Onset Alzheimer Disease;Lead;lead optimization;Learning;Libraries;lipid metabolism;lipidomics;Lipids;Malignant Breast Neoplasm;MCM6 gene;Mediating;medical schools;Memory;Microglia;mid-career faculty;Modeling;mouse model;Mus;myelination;Neuroglia;neuroinflammation;Neurons;Neurosciences;neurotoxicity;novel therapeutics;Oligodendroglia;Partner in relationship;Pathogenesis;Pathologic;patient subsets;Patients;Pharmaceutical Preparations;Phase;phase 2 study;Positioning Attribute;pre-clinical;Prefrontal Cortex;prevent;Protein Isoforms;Risk;Role;rosiglitazone;Science;screening;Secure;Senile Plaques;Small Business Technology Transfer Research;small molecule;small molecule libraries;small molecule therapeutics;Stains;Structure-Activity Relationship;tau Proteins;Therapeutic;therapeutic target;Tissue Model;Titrations;Transgenic Mice;Triglycerides;Validation

PROJECT_TITLE: High-Content Screen to Identify Small Molecule Therapeutics that Reduce Aberrant Lipid Accumulation in APOE4 Alzheimer's Disease

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 NV-H (13)]


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Drug Abuse (NIDA only);HIV/AIDS;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Infectious Diseases;Opioid Misuse and Addiction;Opioids;Prevention;Social Determinants of Health;Substance Misuse

ORG_CITY: NEW HAVEN

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: Project Narrative: Through this Avant-Garde Award, I plan to fill in the gaps of the United States Ending the HIV Plan for persons who use drugs (PWUD). My pioneer award vision is to develop a mobile hub and spoke model that has mobile pharmacies and clinics on wheels that deploy a rapid response sustainable workforce of trained community health workers and pharmacists that literally meet the community where they live. They will provide rapid HIV testing, opioid use disorder (OUD) diagnosis, same day deployment of medication treatment for OUD, PrEP and ART, and retain them on treatment where they live to advance the goal of ending HIV in PWUD.

PI_NAMEs: SPRINGER, SANDRA ANN (contact)

PROGRAM_OFFICER_NAME: WEBB, CANDACE KARONDELETTE

PROJECT_TERMS: addiction;Address;Affect;antiretroviral therapy;Award;career;Caring;Clinic;Clinical;clinical care;Clinical Research;Collaborations;Communicable Diseases;Communities;Community Health Aides;Diagnosis;Diagnostic Services;Disease Outbreaks;Drug usage;Drug user;Ensure;Epidemic;epidemic preparedness;evidence base;experience;Fentanyl;Goals;Health Services Accessibility;HIV;HIV Infections;Hour;Human immunodeficiency virus test;Immigrant;Justice;Medicine;member;Methods;Modeling;opioid use disorder;Overdose;overdose death;Persons;Pharmaceutical Preparations;Pharmacists;Pharmacy facility;Physicians;pre-exposure prophylaxis;Prevention;prevention service;rapid diagnosis;Research;Research Personnel;response;Retinal blind spot;Risk;Services;Stimulant;Substance Use Disorder;Test Result;Testing;testing services;Time;Training;treatment planning;treatment services;Underrepresented Minority;Uninsured;United States;Vision;Woman;Work Ethic

PROJECT_TITLE: Ending HIV: Bringing Integrated Prevention and Treatment Services to People Who Use Drugs Where They Live


ADMINISTERING_IC: AA

IC_NAME: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Neurosciences;Substance Misuse

ORG_CITY: PISCATAWAY

ORG_DEPT: NEUROSCIENCES

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

ORG_STATE: NJ

PHR: PROJECT NARRATIVE Understanding the neurobiological mechanisms of known risk factors for alcohol use disorder (AUD) provides one avenue for developing potential therapeutics. An individual’s response to the stimulating and sedating effects of alcohol represents known risk factors for the development of AUD. The proposed studies use mouse models of alcohol-induced stimulation and sedation to explore the role of striatal astrocytes in modulating neuronal activity to produce these behaviors.

PI_NAMEs: ARDINGER, CHERISH  (contact)

PROGRAM_OFFICER_NAME: AKBAR, MOHAMMED

PROJECT_TERMS: alcohol behavior;Alcohol consumption;alcohol effect;alcohol response;alcohol sensitivity;alcohol testing;alcohol use disorder;Alcohols;Anatomy;Astrocytes;Behavior;behavior prediction;Behavioral;behavioral response;Calcium;calcium indicator;Calcium Signaling;Cells;Clinical;Color;Communication;Corpus striatum structure;Data;Development;Disease;Dopamine D1 Receptor;Dopamine D2 Receptor;Dorsal;drinking;Equilibrium;Ethanol;experimental study;FDA approved;Fiber;Future;genetic approach;high risk;Human;in vivo;in vivo evaluation;Individual;Individual Differences;individual response;insight;Intake;Label;Link;Maps;Measures;Modeling;Molecular Genetics;mouse model;Mus;neural;neurobiological mechanism;Neuroglia;neuroimaging;Neurons;neuroregulation;Neurotransmitter Receptor;neurotransmitter release;neurotransmitter uptake;Pathway interactions;Pharmacotherapy;Photometry;Play;Positioning Attribute;pre-clinical;Process;Receptor Signaling;Research;resilience;Resistance;response;Risk Factors;Rodent Model;Role;Sedation procedure;sedative;Stimulant;Synapses;Synaptic Transmission;Testing;Therapeutic;tool;Transgenic Mice;Work

PROJECT_TITLE: Astrocyte modulation of striatal neuronal activity and behavioral sensitivity to alcohol

STUDY_SECTION_NAME: Special Emphasis Panel[ZAA1 GG (32)]


NIH_SPENDING_CATS: Biotechnology;Brain Disorders;Fragile X Syndrome;Genetics;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences;Rare Diseases

ORG_CITY: BALTIMORE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: PROJECT NARRATIVE The central nervous system relies heavily on mitochondria as one of the most energy consumptive tissues in the body, and mitochondrial dysfunction thereby relates to a plethora of neurodegenerative and neurodevelopmental disorders, such as Fragile X Syndrome (FXS). This study focuses on investigating our finding of miRNA targeting of mitochondrial transcripts in the mammalian forebrain and the possible implications of these binding events in both health and disease, such as altered mitochondrial gene expression which may impact electron transport chain composition and function. If successful, this study will expand our understanding of mitochondrial perturbation during FXS, as well as inform basic molecular biology principles concerning miRNA regulation of mitochondrial gene expression.

PI_NAMEs: EISS, EMILY  (contact)

PROJECT_TERMS: Adult;Alzheimer's Disease;Area;ATP Synthesis Pathway;autism spectrum disorder;Binding;Biochemistry and Cellular Biology;Bioinformatics;Brain;career;cell growth regulation;cell type;Central Nervous System;Communication;crosslink;Cytoplasm;Data;Dedications;Defect;Dendritic Spines;Development;Disease;Electron Transport;Energy-Generating Resources;Enrollment;Environment;Evaluation;Event;excitatory neuron;experimental study;Family;Fellowship;Fragile X Syndrome;Gene Expression;Gene Expression Regulation;genome-wide;Goals;Growth;Health;Huntington Disease;Immunoprecipitation;Induced pluripotent stem cell derived neurons;Investigation;Ligation;Link;medical schools;messenger ribonucleoprotein;Messenger RNA;Metabolic dysfunction;Metabolism;Methods;MicroRNAs;Mitochondria;mitochondrial dysfunction;mitochondrial genome;Mitochondrial Matrix;mitochondrial messenger RNA;Molecular;Molecular Biology;mouse model;mRNA Translation;Mus;Nervous System;Nervous System Disorder;Neurodegenerative Disorders;neurodevelopment;Neurodevelopmental Disorder;Neurons;neuropsychiatric disorder;Oxidative Phosphorylation;Parkinson Disease;Pathology;Patients;Population;Production;programs;Prosencephalon;protein complex;Protein Subunits;Proteins;Reactive Oxygen Species;Regulation;Regulator Genes;Reporting;Research;Resources;Respiratory physiology;RNA;RNA-Binding Proteins;RNA-Induced Silencing Complex;Role;Schizophrenia;Scientist;skills;Source;Specificity;Synaptic plasticity;Technology;Testing;Tissues;Training;training opportunity;Transcript;Translations;Universities;Western Blotting;Writing

PROJECT_TITLE: Characterizing the regulatory roles of microRNA on mitochondria in the mammalian CNS


ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Mental Health;Mental Illness;Rural Health;Social Determinants of Health

PHR: PROJECT NARRATIVE Transgender and gender diverse (TGD) communities in the rural United States experience a disproportionate burden of depression, anxiety, and suicidality due to stigma experienced on the structural level, including laws, policies, social attitudes, and norms. Using both publicly available and survey data, this mixed methods study will explore how recent state-level laws and policies focused on transgender healthcare, as well as the policy environment more broadly, affect the mental health of TGD people. Findings from this study can inform future policy decisions by demonstrating the impact of policies on mental health in the rural TGD community.

PI_NAMEs: SIEBACH, KIRSTEN  (contact)

PROGRAM_OFFICER_NAME: AVENILLA, FRANK R

PROJECT_TERMS: Address;Adult;Affect;Anxiety;Area;Attitude;Birth;career;cisgender;classism;cohort;Cohort Studies;Communities;comparative;Data;depressive symptoms;design;Disclosure;Discrimination;doctoral student;Ecology;Environment;Environmental Risk Factor;Equation;Europe;experience;Exposure to;Fellowship;Funding;Future;Gender;gender affirming care;gender diverse;Gender Identity;General Population;Geography;Goals;Health;health disparity;Health Surveys;Healthcare;high risk;Individual;Institutional Policy;Intervention;Interview;Knowledge;Laws;Lesbian Gay Bisexual Transgender Queer;marginalization;marginalized population;Mental Depression;Mental disorders;Mental Health;mental health policy;Mentors;Mentorship;Methodology;Methods;minority stress;Modeling;Movement;National Institute of Mental Health;Nonprofit Organizations;Outcome;Participant;perceived discrimination;Personal Satisfaction;Persons;Policies;Policy Research;Population;population health;Population Heterogeneity;Prejudice;Process;psychological distress;Public Health Schools;racism;Reporting;Research;Research Design;Research Personnel;Research Priority;Resources;Rights;Rural;rural area;Rural Health;Sampling;sex assigned;skills;social;Social Environment;social stigma;Statutes and Laws;Stigmatization;Strategic Planning;structural determinants;structural health determinants;suicidal;Suicide;Surveys;Techniques;Training;transgender;United States;Universities

PROJECT_TITLE: Structural Stigma and Mental Health Among Transgender and Gender Diverse Adults Living in the Rural United States


NIH_SPENDING_CATS: Bioengineering;Genetics;Human Genome

ORG_CITY: Princeton

ORG_NAME: PRINCETON UNIVERSITY

PHR: PROJECT NARRATIVE Disruptions in fundamental cellular and genetic processes during embryogenesis can lead to developmental defects, which in humans are a major public health burden and leading cause of infant mortality. Interestingly, heritable disruptions to these processes can also lead to morphological diversity over evolutionary time. By studying the developmental basis and molecular evolution of a key morphological innovation, the mammalian gliding membrane, we can gain new insight into how mammals sculpt and shape mesenchyme and skin during development.

PI_NAMEs: SEN, HARSHA  (contact)

PROGRAM_OFFICER_NAME: STEIN, KATHRYN K

PROJECT_TERMS: Acceleration;Architecture;Automobile Driving;Biochemical;Biological;Biological Assay;Biological Models;candidate identification;career;cell behavior;Cell Density;cell motility;Cell Physiology;cell type;Cells;Chiroptera;Cis Tests;Comparative Genomic Analysis;comparative genomics;Complex;Coupled;Data;Defect;Dermis;Development;Developmental Biology;Developmental Process;Educational process of instructing;Elements;Embryonic Development;Epidermis;epigenomics;Evolution;experience;experimental study;Gene Expression;Gene Expression Profile;gene regulatory network;Gene Transfer Techniques;Genes;Genetic;Genetic Processes;Genomic approach;Genomics;Goals;Heritability;Human;Implant;In Vitro;in vivo;Infant Mortality;innovation;insight;Lateral;Ligands;Mammals;mathematical model;mechanical signal;Mechanics;Mediating;Membrane;Mesenchymal;Mesenchyme;migration;Migration Assay;Modeling;Molecular;Molecular Evolution;Morphology;novel;Nucleic Acid Regulatory Sequences;Nucleotides;Organ;outreach;Pattern;Phenotype;Principal Investigator;Process;Professional Competence;professor;programs;promoter;Public Health;Regulatory Element;Reporter;Research;Role;S-Phase Fraction;Shapes;Signal Transduction;skills;Skin;Structure;sugar;Supervision;Testing;Time;Tissues;trait;transcriptomics;Variant;With laterality;Work

PROJECT_TITLE: The cellular mechanisms and molecular evolution of mammalian gliding membrane outgrowth


ED_INST_TYPE: SCHOOLS OF DENTISTRY/ORAL HYGN

NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Dental, Oral, and Craniofacial Disease;Digestive Diseases;Genetics;Infectious Diseases;Pediatric;Perinatal Period - Conditions Originating in Perinatal Period;Pregnancy;Preterm, Low Birth Weight and Health of the Newborn

ORG_CITY: LOS ANGELES

ORG_DEPT: DENTISTRY

ORG_NAME: UNIVERSITY OF CALIFORNIA LOS ANGELES

PHR: PUBLIC HEALTH RELEVANCE STATEMENT This study will examine how metabolism within specific host organs and the resulting metabolites within those host environments affect the virulence potential of Fusobacterium nucleatum, a key colonizer in the development of dental plaque and a pathogen linked to both pre-term birth and colorectal cancer. A better understanding of these host-pathogen relationships is needed to unveil critical new targets for developing anti-infective therapies so as to treat and prevent significant diseases that are associated with this pathogen.

PI_NAMEs: TON-THAT, HUNG  (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Acetaldehyde;Acetyl Coenzyme A;adverse pregnancy outcome;Affect;Amniotic Fluid;Anaerobic Bacteria;Anti-Infective Agents;Applications Grants;Bacterial Adhesins;Binding;Biochemistry;Bioinformatics;Carbon;Catabolism;Cell membrane;Cells;Chorionic villi;Code;Colon;Colorectal Cancer;comparative;Data;Dental Plaque;Development;differential expression;Disease;Distal;Encapsulated;Environment;Environmental Risk Factor;Enzymes;Escherichia coli;Ethanolamine Ammonia-Lyase;Ethanolamines;fetal;Fetal Development;Fetal Tissues;Fetus;First Pregnancy Trimester;Functional disorder;Fusobacterium nucleatum;Future;Gal-GalNAc;Gene Cluster;Genes;Genetic;genetic approach;Genetic Determinism;Goals;Growth;Hematogenous;Human;Hypothetical Protein;Immunity;In Vitro;in vivo;in vivo Model;Infection;Inflammation;Knowledge;Link;Malignant Breast Neoplasm;Mediating;Metabolic;Metabolism;Molecular;Mothers;mouse model;Mouth Diseases;Mus;mutant;Nitrogen;Odontogenesis;oral biofilm;Organ;Organelles;Organism;Parents;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Phosphatidylethanolamine;Phospholipids;Placenta;Play;polymicrobial biofilm;Pregnancy Complications;Premature Birth;prevent;Proteins;public health relevance;pup;Reporting;response;Role;Salmonella;Signal Transduction;Signaling Molecule;Site;Source;stillbirth;Structural Protein;Survival Rate;symbiont;System;Testing;therapeutic target;Third Pregnancy Trimester;Time;Toxic effect;transcriptome sequencing;Umbilical Cord Blood;Virulence;Virulence Factors;Work

PROJECT_TITLE: Metabolic modulation of Fusobacterium nucleatum virulence


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Behavioral and Social Science;Brain Disorders;Clinical Research;Dementia;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Neurodegenerative;Neurosciences;Prevention;Racial and Ethnic Minority Health Research;Social Determinants of Health

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: Project Narrative Establishing how early and mid-life social relations are associated with ADRD risk in different racial/ethnic groups risk provides an innovative, cost effective opportunity to identify modifiable factors in midlife for ADRD risk. This project will capitalize on an existing longitudinal cohort study of detailed social relations over 28 years in a diverse lifespan sample and add cognitive and genetic measures, as well as extend racial/ethnic group comparisons to include Arab Americans in a new regionally representative adult sample in metro-Detroit. Characterizing how social relations vary as a function of race/ethnicity and clarifying unique links to ADRD risk will advance the field in terms of theory and intervention.

PI_NAMEs: ANTONUCCI, TONI CLAUDETTE (contact)

PROGRAM_OFFICER_NAME: KING, JONATHAN W

PROJECT_TERMS: Adult;Age;aged;Alzheimer's Disease Pathway;Alzheimer's disease related dementia;American;Apolipoprotein E;Arabs;Area;behavior measurement;Black Populations;Buffers;Characteristics;Cognition;Cognitive;cohort;comparison group;cost effective;critical period;culturally appropriate intervention;Data;Data Collection;dementia risk;design;Dimensions;Disparity;disparity reduction;Economics;Electronic Mail;ethnic disparity;ethnic minority population;Ethnic Origin;Ethnic Population;experience;Genes;Genetic;Genotype;Health;Incidence;Influentials;innovation;Intervention;late life;Learning;Life Cycle Stages;life span;Link;Longitudinal cohort study;Longitudinal Studies;Measures;member;metropolitan;middle age;Modeling;Modification;novel;Pattern;protective factors;Race;racial difference;racial disparity;racial minority population;racial population;recruit;Resources;Risk;Risk Factors;Sampling;social;social interventions;Socioeconomic Factors;Spouses;Stress;Structure;Testing;theories;trend

PROJECT_TITLE: Racial/Ethnic Disparities in ADRD Risk: The Impact of Social Relations

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Congenital Structural Anomalies;Dental, Oral, and Craniofacial Disease;Genetics;Pediatric;Rare Diseases

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE: Amelogenesis imperfecta is a genetic dental disorder characterized by abnormal enamel development, leading to teeth that are prone to rapid wear, chipping, and increased susceptibility to cavities. The overall objective of this study is to decipher the molecular underpinnings of amelogenesis imperfecta from the perspective of the ameloblast – a specialized cell type that generates enamel. Findings from this research will provide insight into the developmental basis of enamel disorders like amelogenesis imperfecta, which will further contribute to the development of better treatment and therapeutic approaches.

PI_NAMEs: WUEBKER, SAMANTHA  (contact)

PROGRAM_OFFICER_NAME: FUQUA, CHANTEL FAYSAN

PROJECT_TERMS: Actins;Address;Adult;Affect;Ameloblasts;Amelogenesis;Amelogenesis Imperfecta;Bioinformatics;Biological Assay;Cell Count;Cell Line;cell motility;Cell Physiology;cell type;Cells;Cellular Morphology;Child;Co-Immunoprecipitations;Collagen Type IV;comparison control;Complex;Comprehension;Coupled;Cytoskeletal Proteins;Cytoskeleton;Data;Defect;Dental;Dental Enamel;dental genetics;Development;Diagnostic;Disease;Enamel Formation;enamel matrix proteins;Environment;Etiology;Event;experimental study;Fellowship;Fibronectins;Focal Adhesions;Gene Expression;Generations;Genes;Genetic;Genetic Predisposition to Disease;Goals;Histology;Human;Human body;Immunofluorescence Immunologic;improved;in vivo;insight;Institution;Integrins;interest;Knock-out;Knowledge;Lead;Life Cycle Stages;Ligation;live cell imaging;Longevity;Mediating;Mediator;Mentorship;microCT;mineralization;Molecular;Molecular Analysis;Molecular Profiling;morphological criteria;Morphology;mouse genetics;mouse model;Mouth Diseases;Mus;mutant;nanoindentation;Natural regeneration;novel;oral cavity epithelium;oral ectoderm;Pathogenesis;Pathology;Pathway interactions;Phenotype;postnatal;Predisposition;Proteins;Proteomics;psychosocial;Publishing;Regulation;Research;Research Personnel;Research Proposals;Resources;Role;Signal Transduction;single-cell RNA sequencing;skills;Stress Fibers;Techniques;Testing;Therapeutic;Tooth Diseases;Tooth structure;Training;United States;Western Blotting

PROJECT_TITLE: Deciphering the role of MEMO1 during amelogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZDE1 JC (18)]


NIH_SPENDING_CATS: Brain Disorders;Eye Disease and Disorders of Vision;Genetics;Mental Health;Neurosciences;Schizophrenia

PHR: Project Narrative Genetic manipulation in non-genetically tractable, higher mammals, is a critical step towards causally testing hypotheses of sensory information processing and brain development as well as generating disease models that mimic human conditions such as schizophrenia. We will develop and validate a method for rapid and precise delivery of plasmid DNA in ferret primary visual cortex.

PI_NAMEs: SCHOLL, BENJAMIN KYLE (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Adult;Anatomy;area striata;aspartate receptor;Biological Models;Brain;Brain Pathology;Cells;Collaborations;CRISPR/Cas technology;Data;Dependovirus;Detection;Development;disease model;Electrophysiology (science);experience;experimental study;Ferrets;Future;Genes;genetic approach;genetic manipulation;Genetic Materials;Genetic Models;Goals;Guide RNA;Health;Human;In Vitro;in vivo;Individual;information processing;knock-down;Link;Mammals;Measures;Mediating;Methods;millimeter;Mission;Molecular;Mus;N-Methylaspartate;Neocortex;Nervous System Disorder;Neurons;NMDA receptor A1;Operative Surgical Procedures;optogenetics;Physiology;plasmid DNA;Plasmids;Play;Positioning Attribute;postmitotic;postnatal;postnatal development;Primates;Procedures;rapid technique;receptor expression;Reporter;response;Role;Schizophrenia;Sensory;Signal Transduction;Specificity;Stimulus;success;System;Techniques;Testing;Time;Titrations;United States National Institutes of Health;Vision;Visual;Visual Cortex

PROJECT_TITLE: A genetic approach to elucidate the role of NMDA in the development and function of horizontal connections in ferret visual cortex

STUDY_SECTION: NBVP

STUDY_SECTION_NAME: Neuroscience of Basic Visual Processes Study Section[NBVP]


NIH_SPENDING_CATS: Brain Disorders;Congenital Muscular Dystrophy;Congenital Structural Anomalies;Intellectual and Developmental Disabilities (IDD);Muscular Dystrophy;Neurosciences;Pediatric;Rare Diseases

ORG_CITY: ORONO

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MAINE ORONO

ORG_STATE: ME

PHR: Both Congenital Disorders of Glycosylation and dystroglycanopathies are clinically heterogenous, multisystem disorders that can lead to severe progressive neural and muscular degeneration, which deleteriously impacts quality of life and is frequently lethal. There are currently no cures for these diseases. We aim to leverage a zebrafish model to gain insight into tissue-specific impacts of dpm3 expression on neuromuscular development and provide foundational knowledge on mechanisms of disease progression in vivo.

PI_NAMEs: IGNACZ, AMANDA COLLEEN (contact)

PROGRAM_OFFICER_NAME: BARDHAN, SUJATA

PROJECT_TERMS: accurate diagnosis;Address;Adhesions;Affect;Age;Anabolism;Automobile Driving;Biological Assay;Biology;Cell Adhesion;Cell-Matrix Junction;Cessation of life;Clinical;Communication;Complex;confocal imaging;Confocal Microscopy;Congenital disorders of glycosylation;CRISPR/Cas technology;Cytoskeleton;Data;Development;Diffuse;Disease;Disease Management;Disease Progression;Dolichol Phosphates;Dose;Dystroglycan;dystroglycanopathy;Embryonic Development;Event;Exhibits;Extracellular Matrix;Foundations;Future;gene therapy;Generations;Genes;Genetic Models;glycosylation;Goals;Growth;Health;Homeostasis;Human;improved;in vivo;inorganic phosphate;insight;Knowledge;Larva;Life;life span;man;Mannose;Mannosyltransferases;Membrane;Modeling;motor neuron development;Motor Neurons;Muscle;muscle degeneration;Muscle Development;Muscular Dystrophies;muscular structure;mutant;Mutation;Nerve Degeneration;neural;neuromuscular;Neuromuscular Diseases;Neuromuscular Junction;Neurons;Patients;Phenotype;Physiology;Plasmids;Play;Polysaccharides;Post-Translational Protein Processing;postsynaptic;prevent;protein function;Protein Glycosylation;Proteins;Quality of life;receptor;Role;Severities;Site;Skeletal Muscle;stem;Structure;System;Testing;therapeutic target;tissue degeneration;Tissues;Variant;Zebrafish

PROJECT_TITLE: Identifying tissue-specific interactions to bridge mechanisms underlying muscle degeneration in Congenital Disorders of Glycosylation and Dystroglycanopathies

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F10B-Q (20)]


NIH_SPENDING_CATS: Dental, Oral, and Craniofacial Disease;Infectious Diseases;Microbiome

ORG_CITY: BIRMINGHAM

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: Project Narrative Microbial-induced oral diseases are the leading cause of infectious diseases world-wide. Oral commensal streptococci are primary mediators of health and homeostasis in the oral cavity. Hence, it is critically important to understand the molecular mechanisms that govern their fitness and ability to antagonize oral pathogens.

PI_NAMEs: EDMONDS, SARA  (contact)

PROJECT_TERMS: Actinobacillus actinomycetemcomitans;Anabolism;antagonist;antimicrobial;Bacteria;Bacterial Adhesins;biological adaptation to stress;Biological Assay;Biomass;burden of illness;capsule;catalase;Chronic;combat;Communicable Diseases;Data;Defect;Dental caries;Development;differential expression;Dose;Drosophila melanogaster;Ecology;Electron Microscopy;Endodontics;Enterococcus faecalis;Enzymes;feeding;fitness;Genes;Gentian Violet;Goals;Growth;Health;Homeostasis;Hydrogen Peroxide;Individual;Infection;innovation;insight;Invertebrates;Knowledge;Laser Scanning Confocal Microscopy;Literature;Mediating;Mediator;Microbe;microbial;Microbial Biofilms;Modeling;Molecular;Monosaccharides;Mouth Diseases;mutant;Nitrates;Nitrites;Nitrogen Dioxide;nitrosative stress;novel;novel therapeutic intervention;Operon;Oral;Oral cavity;oral commensal;Oral health;oral infection;oral pathogen;oral streptococci;Oxidative Stress;pathogen;Pathogenesis;periodontopathogen;Peroxonitrite;Physiology;Play;polymicrobial biofilm;Polysaccharides;Predisposition;probiotic therapy;Production;Pyruvate Oxidase;Rattus;Reaction;Reactive Nitrogen Species;Reporting;Research;Resistance;restoration;Role;Salivary;Serotyping;Shapes;Stains;Streptococcus;Streptococcus mutans;Streptococcus pneumoniae;stress tolerance;Sucrose;Therapeutic;transcriptome;transcriptomics;Transferase;Virulence;World Health Organization

PROJECT_TITLE: The role of capsule production on the physiology of an oral commensal


NIH_SPENDING_CATS: Breast Cancer;Cancer;Immunotherapy;Women's Health Research

ORG_NAME: METHODIST HOSPITAL RESEARCH INSTITUTE

PHR: Project Narrative This new collaborative project focuses on integrating the parental U01-developed computational tools with single-cell spatial transcriptomic/proteomic data generated from clinical bone metastasis tissue samples to explore why HER2-high tumors may not respond to T-DXd and why HER2-zero tumors can respond.

PI_NAMEs: WONG, STEPHEN TC (contact);ZHANG, XIANG

PROGRAM_OFFICER_NAME: ZAMISCH, MONICA

PROJECT_TERMS: Address;Antibody-drug conjugates;Area;B-Lymphocytes;Biological Assay;Biological Markers;Blood Vessels;bone;Breast Cancer Patient;Breast Cancer therapy;Cancer Center;CD4 Positive T Lymphocytes;CD8-Positive T-Lymphocytes;Cell Communication;cell type;Cells;Clinical;cohort;Collaborations;Combined Modality Therapy;Complex;Computer Models;computerized tools;Conjugating Agent;CSPG4 gene;CTLA4 gene;Data;density;Doctor of Philosophy;Environment;ERBB2 gene;experience;Extracellular Matrix;FDA approved;Fostering;Funding;Human;Immune;Immune system;Immunologist;Immunology;interest;Investigation;Knowledge;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Marketing;Measurable;Mediating;Mesenchymal;Messenger RNA;Metastatic Neoplasm to the Bone;Methodist Church;Modeling;mouse model;nano-string;Natural Killer Cells;Neighborhoods;Neoplasm Metastasis;neoplastic cell;new therapeutic target;novel;objective response rate;Osteoblasts;Osteoclasts;Parents;Pathologist;Pathology;Patients;Preparation;programmed cell death ligand 1;programmed cell death protein 1;programs;Proteins;Proteomics;receptor;Research;Resistance;resistance mechanism;Resolution;response;RNA;Role;Sampling;Signal Transduction;Signaling Molecule;Spatial Distribution;statistics;stem;Stromal Cells;Tissue Sample;tool;transcriptomics;Trastuzumab;treatment response;treatment strategy;tumor;tumor microenvironment;Tumor-infiltrating immune cells;United States National Institutes of Health;Unresectable

PROJECT_TITLE: Spatial single-cell profiling to identify tumor-immune-bone niche features in HER2-low bone metastasis in response to T-DXd treatment.


NIH_SPENDING_CATS: Breast Cancer;Cancer;Genetics;Immunotherapy;Women's Health Research

ORG_CITY: DURHAM

ORG_DEPT: SURGERY

ORG_NAME: DUKE UNIVERSITY

ORG_STATE: NC

PHR: Project Narrative This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 24-029. Although treatment of early-stage HER2+ breast cancers is curative, metastatic HER2+ breast cancer is incurable. This project is relevant to public health because it will demonstrate how HER2 isoforms activate dormancy programs and immune checkpoint to drive tumor dormancy and dissemination of cells that escape the immune system. Our work will provide a new possible strategy for activating the immune system and treating dormant and metastatic tumor cells.

PI_NAMEs: SNYDER, JOSHUA CLAIR (contact)

PROGRAM_OFFICER_NAME: WATSON, JOANNA M

PROJECT_TERMS: adaptive immune response;Animals;Applications Grants;Award;Bar Codes;Biosensor;breast cancer metastasis;Breast Cancer Model;Breast Cancer Patient;cell behavior;Cell Line;cell motility;Cell Transplantation;Cells;checkpoint inhibition;Collaborations;CRISPR/Cas technology;Data;Development;Disinhibition;Disseminated Malignant Neoplasm;Distant Metastasis;Early treatment;ERBB2 gene;Exons;experimental study;Fibroblasts;Fostering;Funding;Future;Genetic Heterogeneity;genetic signature;Goals;Grant;Human;Image;imaging study;Immune;immune activation;immune checkpoint;Immune Evasion;Immune response;Immune system;in vivo;interest;intravital imaging;knock-down;Knock-out;Knowledge;Laboratories;Ligands;Lung;Malignant Breast Neoplasm;Malignant Neoplasms;Manuscripts;Mediating;Metastatic breast cancer;Modeling;Molecular;Monoclonal Antibodies;Monoclonal Antibody Therapy;Motility;mouse model;Mus;N-terminal;nectin;Neoplasm Metastasis;neoplastic cell;Oncogenes;Outcome;overexpression;parent project;Parents;Pathway interactions;Pilot Projects;prevent;Primary Neoplasm;Prognosis;programs;Protein Isoforms;Proto-Oncogenes;Public Health;Regulatory T-Lymphocyte;Resistance;Resources;response;RNA Splicing;Role;Signal Transduction;success;targeted treatment;Technology;Testing;therapy resistant;Time;tool;transcriptomics;Transplantation and Immune System;Trastuzumab;tumor;Tumor Cell Line;tumor heterogeneity;tumor-immune system interactions;Tumor-infiltrating immune cells;Visualization;Visualization software;Work

PROJECT_TITLE: Visualizing cell dormancy in a Her2 Crainbow model of breast cancer metastasis


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Diabetes;Obesity

ORG_CITY: CAMBRIDGE

ORG_NAME: VAXESS TECHNOLOGIES, INC.

ORG_STATE: MA

PHR: Project Narrative To expand the benefits of GLP-1 receptor agonists, strategies to improve adherence to treatment are needed. The proposed work aims to address key factors linked to poor adherence by developing a needle-free, shelf-stable, self-applied, microneedle array patch (MAP) using the MIMIXTM platform for delivery of a GLP-1 RA.

PI_NAMEs: TUSSEY, LYNDA  (contact)

PROGRAM_OFFICER_NAME: COOKE, BRAD

PROJECT_TERMS: Acceleration;Address;Adherence;Adult;Affect;Agonist;analog;assay development;Beta Cell;Biological Assay;Cell Physiology;Chronic;Clinical;Data;Dermis;Deterioration;Development;Devices;diabetes management;Diagnosis;Dose;Drug Delivery Systems;Dryness;effective therapy;Engineering;Excipients;experience;Failure;Fibroins;Formulation;Frequencies;Fright;GLP-I receptor;glucagon-like peptide 1;glucose production;Glycosylated hemoglobin A;Goals;Half-Life;Health;Hepatic;High Pressure Liquid Chromatography;Home;Hypoglycemia;Impairment;improved;Insulin Resistance;Lead;lead candidate;Link;Mechanics;Medical;medication compliance;meetings;Metabolic Diseases;Metabolic dysfunction;Methods;Modification;Needles;Non-Insulin-Dependent Diabetes Mellitus;novel;Obesity;obesity treatment;Overdose;Patients;Penetration;Peptides;Perception;Pharmaceutical Preparations;Phase;Plasma;Positioning Attribute;preservation;Printing;Procedures;Process;Production;Recovery;Regimen;Regulation;Renal clearance function;Silk;Societies;Specific qualifier value;stability testing;Structure of beta Cell of islet;Testing;Therapeutic;Therapeutic Effect;therapeutic target;Time;Uninsured Medical Expense;vaccine distribution;Work

PROJECT_TITLE: Development of a Needle Free Microarray Patch for Delivery of a GLP-1 Receptor Agonist


ORG_CITY: CHAPEL HILL

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

PHR: NARRATIVE Kaposi Sarcoma (KS) is the most common cancer in people living with HIV today. In the UNC Lineberger Comprehensive Cancer Center capture area, KS cases disproportionally manifest in African Americans. This supplement application responds uses data from existing cohorts to study the importance of KSHV viral load and the immune system as biomarkers in modern AIDS-KS treatments.

PI_NAMEs: EARP, H. SHELTON (contact)

PROGRAM_OFFICER_NAME: SHAFIK, HASNAA

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Administrative Supplement;Adult;Africa South of the Sahara;African American population;Aging;AIDS clinical trial group;AIDS Malignancy Consortium;antiretroviral therapy;Area;B-Cell Antigen Receptor;B-cell receptor repertoire sequencing;biobank;Bioinformatics;Biological Assay;Biological Markers;Biopsy;Cancer Center;Cancer Center Support Grant;Cancer Research Project;cancer risk;cancer specimen resource;cancer therapy;CD4 Lymphocyte Count;Cell Physiology;Cells;Certification;chemotherapy;Clinical;Clinical Data;clinical phenotype;clinical trial analysis;Clinical Trials;clinically actionable;cohort;Collection;Complement;Comprehensive Cancer Center;Cytotoxic Chemotherapy;Data;Data Set;digital;Disease;DNA;Equipment;Equipment and supply inventories;Etoposide;Funding;Future;General Population;Genetic Transcription;Herpesviridae Infections;HIV;HIV Infections;HIV/AIDS;Human Herpesvirus 8;Immune;Immune system;Immunotherapy;Infrastructure;international partnership;Kaposi Sarcoma;Lesion;Malawi;Malignant Neoplasms;men;Modernization;Molecular;molecular phenotype;Mozambique;multidimensional data;NCI-Designated Cancer Center;new technology;New York;Nivolumab;novel;Outcome;Paclitaxel;Participant;Patients;pediatric human immunodeficiency virus;Peripheral Blood Mononuclear Cell;Persons;Plasma;Prevalence;progression marker;Progressive Disease;prospective;Publishing;randomized trial;Reporting;Research;response;Role;Sampling;San Francisco;single-cell RNA sequencing;Slide;South Africa;Specimen;statistics;Surveys;T-Lymphocyte;Tanzania;Technology;Testing;Time;Translational Research;trial design;Uganda;UNC Lineberger Comprehensive Cancer Center;Variant;Viral load measurement;Viral Load result;Virus Replication;whole genome;Work;Zambia

PROJECT_TITLE: Analysis of HIV+ cancer samples from the AMC and ACSR


NIH_SPENDING_CATS: Autism;Behavioral and Social Science;Biomedical Imaging;Brain Disorders;Clinical Research;Intellectual and Developmental Disabilities (IDD);Mental Health;Neurosciences

ORG_CITY: Nashville

ORG_NAME: VANDERBILT UNIVERSITY

ORG_STATE: TN

PHR: PROJECT NARRATIVE Atypical facial expressivity is a common characteristic of autism that is strongly associated with negative social and mental health outcomes. This work seeks to identify the neural basis of atypical facial expression in autism using functional neuroimaging, clinical, and behavioral data. Generated findings will inform the necessary development of targeted, evidence-based interventions for this critical nonverbal communication barrier.

PI_NAMEs: BRESS, KIMBERLY SUMMER (contact)

PROGRAM_OFFICER_NAME: CORNELL, ASHLEY ROSE

PROJECT_TERMS: Address;Adult;adult with autism spectrum disorder;Anxiety Disorders;Area;autism spectrum disorder;autistic;Behavior;behavior measurement;Behavioral;Brain;Brain imaging;Brain region;Characteristics;Clinical;Clinical assessments;clinically relevant;Collection;Communication Barriers;Community Networks;comorbidity;Complex;Data;data exchange;Data Set;Development;Emotional;emotional stimulus;Emotions;Esthesia;Etiology;Evidence based intervention;experience;Eye;Face;Facial Expression;Facial Muscles;Feedback;feeding;Functional Magnetic Resonance Imaging;gaze;Goals;Graph;Impairment;improved;Individual;individuals with autism spectrum disorder;Intervention;Laboratories;Measures;Mental Health;Mood Disorders;Motivation;Motor;motor control;neural;neuroimaging;Nonverbal Communication;open data;Outcome;Pain;Pathway interactions;Pattern;peer;Personal Communication;prevent;Publishing;Rest;Sampling;Sensorimotor functions;Sensory;skills;social;Social Development;Speech;Structure;System;targeted treatment;Testing;therapeutic target;Work

PROJECT_TITLE: Sensorimotor Control of Facial Expression in Autism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F02B-E (20)]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Eye Disease and Disorders of Vision;Mental Health;Neurodegenerative;Neurosciences

ORG_CITY: BOSTON

ORG_DEPT: PSYCHOLOGY

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: PROJECT NARRATIVE The proposed research will characterize the flow of visuospatial information along a circuit involving the rodent pulvinar, postrhinal cortex, and medial entorhinal cortex that transforms high-dimensional sensory information into straightforward spatial representations that can guide spatial memory and behavior. Dysfunction in these brain regions is associated with cognitive impairments in disorders such as Alzheimer’s disease and topographical disorientation. Understanding the precise functional connections among these regions may provide insight into mechanisms underlying these disorders and will significantly expand our understanding of the neural processing of space.

PI_NAMEs: LACHANCE, PATRICK ADAM (contact)

PROGRAM_OFFICER_NAME: VAN'T VEER, ASHLEE VICTORIA

PROJECT_TERMS: Alzheimer's Disease;Anatomy;Animals;Area;behavioral study;Binding;Brain;Brain region;cell cortex;cell type;Cells;Code;Computer Models;Coupling;Cues;Darkness;Data Analyses;Disease;Disorientation;Electrophysiology (science);Elements;entorhinal cortex;Environment;Exhibits;experience;experimental study;Functional disorder;Future;Genetic;Head;high dimensionality;Hippocampus;Homologous Gene;Human;Impaired cognition;in vivo;Individual;insight;Label;Lateral;Light;Maps;Medial;Methods;Modeling;neural;neural circuit;neuromechanism;Neurons;optic flow;Pathway interactions;Patients;Persons;Positioning Attribute;Property;Psyche structure;Pulvinar structure;Research;Rodent;Sensory;Signal Transduction;Site;Spatial Behavior;spatial memory;superior colliculus Corpora quadrigemina;Testing;Thalamic structure;Visual;Visual Cortex;visual information;Visuospatial;way finding;Work

PROJECT_TITLE: Thalamocortical Circuits Governing Egocentric-Allocentric Spatial Reference Frame Transformations

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1 F01B-M (20)]


ORG_CITY: MINNEAPOLIS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MINNESOTA

ORG_STATE: MN

PHR: PROJECT NARRATIVE Similar to electrical circuits, cells possess enzymatic circuits that sense, signal and respond to the presence of redox-active stimuli in their microenvironment. We will design molecular strategies to rewire enzymatic redox circuitry that will enable cells to overcome excess or deficiency of critical redox reagents. These strategies will inform future methodologies for prevention and treatment of several redox-related diseases including cancer, cardiovascular and neurological disorders.

PI_NAMEs: BHAGI, AMBIKA  (contact)

PROGRAM_OFFICER_NAME: ANSONG, CHARLES KWAKU

PROJECT_TERMS: Acute;Bacteria;Binding;Bioinorganic Chemistry;Biological;Biology;Carbon Monoxide;Cardiovascular Diseases;Cell Physiology;Cells;Chemicals;Chronic;Communication;Degenerative Disorder;design;Disease;DNA;Environment;Enzymatic Biochemistry;Equilibrium;Event;Future;Genus Mycobacterium;Goals;Health;heme a;Heme Iron;Homeostasis;Human;Laboratories;Life;Maintenance;Malignant Neoplasms;Metalloproteins;Metals;Methodology;Molecular;Nervous System Disorder;Nitric Oxide;Oxidation-Reduction;peptidomimetics;Phenotype;Phosphotransferases;Physiological;Physiological Processes;Plants;Prevention;Process;programs;Protein Engineering;Reaction;Reactive Oxygen Species;Reagent;Research;response;Side;Signal Pathway;Signal Transduction;Signal Transduction Pathway;Specificity;Spectrum Analysis;Stimulus;Stress;Structure;System;Work;Zinc

PROJECT_TITLE: Decoding and Rewiring Enzymatic Redox Signal Transduction Pathways

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1(55)-R]


ED_INST_TYPE: SCH ALLIED HEALTH PROFESSIONS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Pediatric

PHR: PROJECT NARRATIVE Predicting language outcomes in children referred for early language concerns is a longstanding clinical and scientific challenge that often results in the delayed implementation of intervention. The overarching goal of this project is to examine how speech skills and motor skills are related to language function in children with and without early delays in language abilities. An improved understanding of these relationships will advance clinicians’ ability to make informed prognoses of language outcomes for children at risk of language impairments and will also inform future research aimed at improving the assessment and treatment of language disorders.

PI_NAMEs: MAFFEI, MARC  (contact)

PROGRAM_OFFICER_NAME: SCHURMAN, JACLYN REBECCA

PROJECT_TERMS: 2 year old;Acoustics;Address;Age;Algorithms;Area;autistic children;Boston;Child;Childhood;Clinical;clinical decision-making;clinical diagnosis;clinically significant;Cognitive;cohort;Collection;Communication;Complex;complex data;Data;Development;Early identification;Elasticity;Environment;Exhibits;feature selection;Fellowship;Functional disorder;Goals;implementation intervention;improved;Investigation;Language;Language Delays;Language Development;Language Disorders;language impairment;language outcome;Learning;lexical;Locomotion;longitudinal dataset;Machine Learning;Measures;Methodology;Methods;Motor;Motor Skills;National Institute on Deafness and Other Communication Disorders;natural language;Neurodevelopmental Disorder;novel strategies;Outcome;outcome prediction;Pathologist;peer;phonology;Play;Population;precision medicine;predictive modeling;Procedures;Process;Prognosis;prognostic;psychosocial;recruit;Regression Analysis;Research;Research Personnel;Risk;Sampling;Semantics;Severities;skills;Speech;Speech Acoustics;Speed;Statistical Methods;Statistical Models;Structure;Techniques;Training;training project;Universities;Video Recording

PROJECT_TITLE: Speech, Language, and Motor Skills in Late Talkers

STUDY_SECTION_NAME: Special Emphasis Panel[ZDC1 SRB-N (36)]


NIH_SPENDING_CATS: Alcoholism, Alcohol Use and Health;Behavioral and Social Science;Brain Disorders;Genetics;Natural Products;Neurosciences;Substance Misuse

ORG_CITY: PITTSBURGH

ORG_DEPT: ANESTHESIOLOGY

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

ORG_STATE: PA

PHR: Narrative Alcohol Use Disorder is one of the most prevalent and debilitating psychiatric disorders, yet little is known about the biological processes that underlie the development of AUD. My research proposal will investigate the role of long non-coding RNA Malat1 in regulating astrocyte-mediated neuroinflammation and ethanol consumption.

PI_NAMEs: GIL, DANIELA VICTORIA (contact)

PROGRAM_OFFICER_NAME: LORANG-LEINS, DOMINIQUE

PROJECT_TERMS: Acute;Adult;alcohol behavior;Alcohol consumption;alcohol exposure;alcohol response;alcohol testing;alcohol use disorder;Alcohols;Anti-Inflammatory Agents;Astrocytes;Attenuated;Autopsy;Behavior;Behavioral;behavioral pharmacology;Binding;Bioinformatics;Biological Process;Brain region;Cell Physiology;cell type;Cellular Morphology;Central Nervous System;Chemicals;Chronic;Code;conditioned place preference;Data;Development;Disease;drinking;drinking behavior;Ethanol;Female;Gene Expression;Gene Expression Regulation;Genes;Genetic Transcription;Genetically Engineered Mouse;glial activation;Glial Fibrillary Acidic Protein;Human;Immune;Immunofluorescence Immunologic;In Situ;in vivo;Individual National Research Service Award;Inflammasome;Inflammatory;insight;Knock-out;Knockout Mice;Laboratories;Link;magnetic beads;MALAT1 gene;male;Medial;Mediating;Mediator;Mental disorders;Molecular;Molecular Biology Techniques;Morphology;Mus;Neurobiology;Neuroglia;Neuroimmune;neuroinflammation;new therapeutic target;novel;novel strategies;Pathogenesis;Pathway interactions;pharmacologic;Phenotype;Physiological;Play;pre-doctoral;preference;Prefrontal Cortex;Process;Proteins;Quercetin;receptor;Regulation;Research Proposals;response;Rewards;RNA;RNA-Protein Interaction;Rodent;Role;Signal Transduction;single nucleus RNA-sequencing;small molecule;Testing;Tissues;Training;Transcriptional Regulation;transcriptomics;Untranslated RNA

PROJECT_TITLE: Role of lncRNA Malat1 in Alcohol Use Disorder


NIH_SPENDING_CATS: Brain Cancer;Brain Disorders;Cancer;Coronaviruses;Coronaviruses Therapeutics and Interventions;Data Science;Emerging Infectious Diseases;Genetics;Infectious Diseases;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Orphan Drug;Pediatric;Pediatric Cancer;Rare Diseases

ORG_CITY: EAST LANSING

ORG_DEPT: PEDIATRICS

ORG_NAME: MICHIGAN STATE UNIVERSITY

PHR: Project Narrative The goal of this proposal is to address some fundamental issues in leveraging the emerging omics and artificial intelligence to discover novel compounds. It will apply the methods into real drug discovery studies including pediatric cancers.

PI_NAMEs: CHEN, BIN  (contact);ZHOU, JIAYU

PROGRAM_OFFICER_NAME: YUAN, JEAN

PROJECT_TERMS: Address;analog;Artificial Intelligence;artificial intelligence model;Brain;Cell Reprogramming;Chemical Structure;cost;Data;Data Science;deep reinforcement learning;Development;Diffuse intrinsic pontine glioma;Disease;drug discovery;drug efficacy;drug repurposing;Drug Screening;Gene Expression;Gene Expression Profile;Goals;inhibitor;lead optimization;Libraries;Machine Learning;machine learning method;Malignant Childhood Neoplasm;Malignant neoplasm of liver;Methods;Mycophenolic Acid;novel;novel therapeutics;parent project;Penetration;Performance;Pharmaceutical Chemistry;Pharmaceutical Preparations;Research;SARS-CoV-2 inhibitor;screening;Solubility;Technology;virtual;Work

PROJECT_TITLE: Research Supplement to Promote Diversity for R01GM145700

STUDY_SECTION: BDMA

STUDY_SECTION_NAME: Biodata Management and Analysis Study Section[BDMA]