NIH_SPENDING_CATS: Cancer;Lung;Lung Cancer

PHR: PROJECT NARRATIVE The recent FDA approval of sotorasib, a direct pharmacological inhibitor of KRASG12C, marks a critical milestone in the treatment of lung cancer, but primary or acquired resistance remain major obstacles in sustaining durable patient responses to this therapy. Based on compelling preliminary data, this proposal seeks to test the hypothesis that combined inhibition of KRASG12C plus the intracellular recycling process of autophagy will lead to superior tumor control in preclinical models. We will also test how genetic alterations that cooperate with KRASG12C to promote lung carcinogenesis, such as silencing of LKB1, influences response to KRASG12C inhibition to develop a deeper mechanistic understanding of these cellular processes and potential clinical impact.

PI_NAMEs: GHAZI, PHAEDRA  (contact)

PROGRAM_OFFICER_NAME: SCHMIDT, MICHAEL K

PROJECT_TERMS: Aftercare;Aggressive behavior;Autophagocytosis;Basic Science;Biochemical Process;cancer cell;Cancer cell line;Cancer Etiology;Cancer Model;Cancer Patient;Cell Line;Cell Physiology;Cell Survival;Cells;Cellular Stress;Cessation of life;Chimeric Proteins;Clinical;Clinical Trials;CRISPR/Cas technology;Cytoprotection;cytotoxic;Data;Dependence;detection of nutrient;Diagnosis;Disease;Engineering;Euthanasia;FDA approved;Flow Cytometry;fluorescence imaging;Future;Genes;Genetic;Genetically Engineered Mouse;Goals;Human;Human Cell Line;Immunohistochemistry;improved;inhibition of autophagy;inhibitor;Investigation;KRAS2 gene;KRASG12D;life span;lung cancer cell;lung carcinogenesis;lung health;lung lesion;Lung Neoplasms;lung tumorigenesis;Malignant neoplasm of lung;Malignant Neoplasms;MAP2K1 gene;Measures;men;microCT;Modeling;mouse model;Mus;mutant;Mutate;Mutation;never smoker;novel;Nutrient;Oncogenes;Pathway interactions;patient response;patient subsets;Patients;pharmacologic;Phosphorylation;Phosphotransferases;Pre-Clinical Model;predictive marker;Process;Proliferating;Proteins;Recycling;Regulation;Reporter;Research;Research Project Grants;Resistance;resistance mechanism;response;Role;Signal Induction;Signal Transduction;standard care;STK11 gene;Survival Rate;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;therapeutic target;therapeutically effective;therapy outcome;therapy resistant;Translating;treatment response;tumor;Tumor Burden;tumor growth;tumor initiation;tumor xenograft;United States;Up-Regulation;Western Blotting;Woman;Work;X-Ray Computed Tomography;Xenograft procedure

PROJECT_TITLE: Investigating KRAS Signaling and Autophagy Co-inhibition in KRAS-mutant Lung Cancer


ADMINISTERING_IC: HL

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Genetics;Lung;Pediatric

ORG_CITY: STANFORD

ORG_COUNTRY: UNITED STATES

ORG_DEPT: PEDIATRICS

ORG_FIPS: US

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: The formation of the distal air sacs (alveolarization) requires the development of blood vessels by the process of angiogenesis. Disruption of angiogenesis and alveolarization in infants causes bronchopulmonary dysplasia, the most common complication of premature birth. Our studies will explore if lung immune cells regulate angiogenesis in the developing lung, and identify new pathways to allow the development of therapeutic strategies to promote lung growth and regeneration in both infants and adults with lung disease.

PI_NAMEs: ALVIRA, CRISTINA MARIA (contact)

PROGRAM_OFFICER_NAME: LIN, SARA

PROJECT_TERMS: Acute;Adult;Air Sacs;Alveolar;Alveolar Macrophages;Alveolus;Anastomosis - action;angiogenesis;Area;arteriole;Basement membrane;Birth;blood vessel development;Blood Vessels;Bronchopulmonary Dysplasia;Cell Communication;Cells;chemokine;Chronic;Complex;Complication;conditional knockout;Coronary artery;Cues;Data;Data Set;Development;Disease;Distal;Embryo;Endothelial Cells;Epithelial Cells;Exhibits;Gases;Gene Expression;Genes;genetic signature;Genetic Transcription;Growth;Heart;Heterogeneity;hindbrain;Hyperoxia;Image;Immune;Immunity;Impairment;In Situ;In Situ Hybridization;In Vitro;in vivo;Infant;Injury;Knockout Mice;Life;Ligands;Location;Lung;lung development;Lung Diseases;Macrophage;Mediating;Molecular;mouse model;Myofibroblast;Natural Immunity;Natural regeneration;Neuropeptides;novel strategies;Organ;Pathway interactions;Pattern;Phenotype;Physiological;Placenta;Play;Population;postnatal;postnatal development;Premature Birth;Process;Pulmonary Circulation;pulmonary function;rapid growth;receptor;Recovery;recruit;repaired;Resolution;Retina;Role;Serine Proteinase Inhibitors;Signal Pathway;Signal Transduction;single-cell RNA sequencing;Smooth Muscle Myocytes;Spatial Distribution;Stromal Cell-Derived Factor 1;Surface;Testing;therapeutic development;Tissues;transcriptomics;Transgenic Organisms;Translating;Vascular Permeabilities;Vascular remodeling;Vascular Smooth Muscle;Vascularization

PROJECT_TITLE: Diverse Homeostatic Roles for Distinct Macrophages in the Developing Lung Vasculature

STUDY_SECTION: RIBT

STUDY_SECTION_NAME: Respiratory Integrative Biology and Translational Research Study Section[RIBT]


NIH_SPENDING_CATS: Aging;Bioengineering;Biomedical Imaging;Brain Disorders;Cerebrovascular;Clinical Research;Hematology;Neurosciences;Prevention;Rare Diseases;Sickle Cell Disease;Stem Cell Research;Stem Cell Research - Nonembryonic - Human;Stroke

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: PROJECT NARRATIVE / PUBLIC HEALTH RELEVANCE In contrast to children with sickle cell anemia (SCA) in whom stroke prevention screening has been highly successful, methods to identify adults with SCA at highest risk of new or recurrent stroke have not been developed and are urgently needed. This study uses multiple novel brain imaging techniques to measure differences in brain oxygen consumption, brain blood flow, and brain structure in adults with SCA that progress to develop new strokes, and also to understand how these methods can be used to evaluate the effect of curative SCA treatments on brain health. Study findings are intended to improve stroke risk assessment and allow individualized care to eventually prevent strokes in adults with SCA.

PI_NAMEs: DONAHUE, MANUS J;JORDAN, LORI CHAFFIN (contact)

PROGRAM_OFFICER_NAME: PHILP, DEBORAH

PROJECT_TERMS: Address;Adult;Age;aggressive therapy;arteriole;Biological Markers;biomarker identification;Blood;Blood Transfusion;Brain;brain health;Brain imaging;brain tissue;Caring;Central Nervous System;cerebral hemodynamics;Cerebral Infarction;Cerebrovascular Circulation;cerebrovascular reactivity;Cerebrum;Child;Chronic;Clinical;Clinical Trials;cohort;Contrast Media;Cross-Sectional Studies;curative treatments;Data;Development;Enrollment;Equipment;Evaluation;evidence base;Future;Genetic Diseases;Goals;Health;Hematopoietic Stem Cell Transplantation;hemodynamics;Hemolytic Anemia;High Prevalence;high risk;high risk population;hydroxyurea;Imaging Device;imaging science;Imaging Techniques;Impairment;improved;in vivo;Individual;Infarction;Intracranial Arterial Stenosis;Ischemic Brain Injury;life span;Long term disability;Longitudinal Studies;longitudinal, prospective study;Magnetic Resonance Imaging;Measurement;Measures;Medical;Metabolic;metabolic profile;Methods;Modeling;Multi-Institutional Clinical Trial;multidisciplinary;neuroimaging;novel;Oxygen;Oxygen Consumption;Participant;patient stratification;Patient Triage;Patients;personalized care;Population;post stroke cognitive impairment;Prevention strategy;Prevention therapy;Procedures;progression risk;prospective;public health relevance;Recurrence;Relaxation;Reproducibility;response;Rest;Retrospective cohort;Risk;Risk Assessment;Risk Factors;Role;Scanning;screening;Screening procedure;sex;Sickle Cell Anemia;Stem cell transplant;Stimulus;Stroke;Stroke prevention;stroke risk;stroke therapy;Structure;Techniques;Testing;Time;Tissues;tool;Transfusion;treatment response;Triage;Universities;Vascular Diseases;Work

PROJECT_TITLE: Biomarkers of ischemic brain injury in adults with sickle cell disease

STUDY_SECTION: ANIE

STUDY_SECTION_NAME: Acute Neural Injury and Epilepsy Study Section[ANIE]


ADMINISTERING_IC: MH

FUNDING_MECHANISM: TRAINING, INDIVIDUAL

IC_NAME: NATIONAL INSTITUTE OF MENTAL HEALTH

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Brain Disorders;Clinical Research;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Pediatric;Serious Mental Illness

ORG_CITY: PORTLAND

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

ORG_NAME: OREGON HEALTH & SCIENCE UNIVERSITY

ORG_STATE: OR

PHR: PROJECT NARRATIVE  Adolescent major depressive disorder (MDD) is a potentially debilitating disorder which increases the risk for suicide, and recently, rising youth mental health concerns since 2021 have been declared a national emergency; yet, treatment efficacy continues to fall short in subsiding depressive symptoms. The goal of this proposal is to improve our understanding of the role reward processing and reward-related learning behaviors play in adolescents with MDD, and aims to investigate how neurobiological reward mechanisms in adolescence are related to future reward-related behavior. In building a stronger framework of reward-learning behavior and neurobiological marker predictability of future reward-learning behavior in adolescents, the potential findings of this proposal may better inform individualized treatment strategies.

PI_NAMEs: DEL GIACCO, AMANDA C (contact)

PROGRAM_OFFICER_NAME: SABBAGH, JONATHAN JACOB

PROJECT_TERMS: Academy;Adolescence;Adolescent;Adolescent Psychiatry;adolescent-onset depression;Adult;age group;American;Behavior;behavioral phenotyping;Brain;Cause of Death;child depression;Child Psychiatry;comorbidity;Control Groups;Data Set;Decision Making;Depressed mood;depressive symptoms;Disease;Disease remission;Early identification;Emergency Situation;emerging adult;endophenotype;evidence base;Future;Goals;hedonic;Height;high risk;Impairment;improved;Individual;Individual Differences;individualized medicine;insight;Intervention;learned behavior;Learning;Life;Link;Literature;Major Depressive Disorder;Measures;Mediating;Mediation;Mental Depression;Mental disorders;Mental Health;neural;neural circuit;neurobiological mechanism;Neurobiology;neuroimaging;Neuronal Plasticity;Onset of illness;Outcome;peer;personalized intervention;Pharmaceutical Preparations;Phenotype;Play;Prevention;Psychopathology;Psychotherapy;Research;response;Rest;reward circuitry;reward dysfunction;reward processing;Rewards;Risk;Role;Severities;standard care;Stimulus;substance use;Substance Use Disorder;success;suicidal risk;Suicide;Suicide attempt;System;Time;Treatment Efficacy;treatment response;treatment strategy;Ventral Striatum;Visit;young adult;Youth

PROJECT_TITLE: Comparing reward learning among adolescents and adults with MDD and using reward-related neurobiology to predict future reward-related learning


ADMINISTERING_IC: GM

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biotechnology

ORG_CITY: LAS VEGAS

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF NEVADA LAS VEGAS

ORG_STATE: NV

PHR: The cullin-RING ligases (CRLs) are under intense investigation as targets for human therapeutics. The multi- purpose drug thalidomide is already known to target a CRL, and a novel potent inhibitor of CRLs named Prevonedistat is currently under investigation in clinical trials as a cancer therapy. Most recently, CRLs are being employed by proximity-inducing drugs called proteolysis-targeting chimeras (PROTACs) to promote the degradation of disease-causing proteins, and the work proposed in this grant is likely to help in the development of these human therapies that exploit the CRLs.

PI_NAMEs: KLEIGER, GARY L. (contact)

PROGRAM_OFFICER_NAME: PHILLIPS, ANDRE W

PROJECT_TERMS: Ablation;Affect;Architecture;Area;Binding;Biological;Biological Assay;Biology;Biotechnology;cancer therapy;Cell Line;Cells;Clinic;Clinical Trials;Code;Collaborations;Communities;Complement;Complex;Cullin Proteins;Development;Disease;Endowment;enzyme activity;Enzyme Interaction;Enzymes;expectation;Family;feeding;Grant;Human;human disease;In Vitro;Individual;Industry;inhibitor;interest;invention;Investigation;Kinetics;Knock-out;Life;Ligase;Literature;Malignant Breast Neoplasm;Malignant neoplasm of prostate;Malignant Neoplasms;Mass Spectrum Analysis;Measures;Mediating;member;Modality;Modeling;Modification;multicatalytic endopeptidase complex;Multiple Myeloma;Names;novel;novel therapeutics;Outcome;p38 Mitogen Activated Protein Kinase;Pharmaceutical Preparations;pharmacologic;Phosphorylation;Phosphotransferases;Physiological;Polyubiquitin;Protac;protein degradation;Protein Dephosphorylation;Protein Inhibition;Protein Kinase;Protein phosphatase;protein protein interaction;Proteins;Proteome;Proteomics;receptor;Receptor Protein-Tyrosine Kinases;reconstitution;recruit;Regulation;Research;Resistance;Resolution;Role;scaffold;small molecule;Specificity;Structure;System;Techniques;Testing;Thalidomide;Therapeutic;Ubiquitin;ubiquitin ligase;Work

PROJECT_TITLE: How ubiquitin-carrying enzymes contribute to ubiquitin ligase specificity

STUDY_SECTION: MBPP

STUDY_SECTION_NAME: Membrane Biology and Protein Processing Study Section[MBPP]


ADMINISTERING_IC: AI

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Genetics;Immunization;Infectious Diseases;Malaria;Prevention;Rare Diseases;Vaccine Related;Vector-Borne Diseases

ORG_CITY: NEW HAVEN

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: YALE UNIVERSITY

ORG_STATE: CT

PHR: NARRATIVE Plasmodium sporozoites are transmitted to a vertebrate host by Anopheles mosquitoes. We have shown that mosquito saliva proteins can influence the infectivity of sporozoites, and identified two sporozoite associated mosquito saliva proteins, SAMSP1 and SAMSP2. We will now determine the effects of SAMSP1 and SAMSP2 on Plasmodium infection in vitro and in vivo; this will lead to a greater understanding of the earliest phase of Plasmodium infection of a vertebrate host and may facilitate the development of a potential vector-based malaria vaccine.

PI_NAMEs: DIMOPOULOS, GEORGE ;FIKRIG, EROL  (contact)

PROGRAM_OFFICER_NAME: COSTERO-SAINT DENIS, ADRIANA

PROJECT_TERMS: Active Immunization;Affect;Anopheles gambiae;Anopheles Genus;Bite;Blocking Antibodies;Blood Vessels;Cells;Cellular Immunity;Clustered Regularly Interspaced Short Palindromic Repeats;combat;Culicidae;Data;Deposition;Dermis;Development;Gene Expression;Gene Silencing;Gene Transfer Techniques;Human;Image;Immune;Immune response;Immunity;Immunization;immunoregulation;In Vitro;in vitro Assay;in vivo;Infection;intradermal injection;intravital imaging;Invaded;Lead;loss of function;Malaria;Malaria Vaccines;Measures;migration;mosquito-borne;Motility;Movement;Mus;overexpression;Passive Immunization;pathogen;Phase;Plasmodium;Proteins;RNA Interference;Role;Saliva;Serum;Site;Skin;Speed;Sporozoites;T-Lymphocyte;Testing;transcriptome sequencing;transcriptomics;transmission process;two photon microscopy;two-photon;vector

PROJECT_TITLE: Mosquito SAMSP1 and SAMSP2 influence the initial stage of Plasmodium infection of mice

STUDY_SECTION: VB

STUDY_SECTION_NAME: Vector Biology Study Section[VB]


NIH_SPENDING_CATS: Aging;Neurodegenerative;Neurosciences

ORG_CITY: COLLEGE STATION

ORG_NAME: TEXAS A&M UNIVERSITY

ORG_STATE: TX

PHR: The fundamental research in this proposal will have important public health implications for understanding iron metabolism and mitochondrial dysfunction. Defects in the biogenesis of iron-sulfur clusters are directly associated with cardiovascular and neurodegenerative disease, and contribute to genomic instability, the development of cancer, and aging.

PI_NAMEs: BARONDEAU, DAVID P (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TERMS: 4'-phosphopantetheine;Acyl Carrier Protein;Acylation;Address;Aging;Alzheimer's Disease;Amino Acids;Amyotrophic Lateral Sclerosis;Anabolism;Architecture;Biochemical Process;Biogenesis;Biological;Biological Assay;Cardiovascular Diseases;Catalytic Domain;Cell Death;Cellular Metabolic Process;Clinical;cofactor;Complex;Coupled;cysteine desulfurase;Defect;Development;Disease;electron donor;Electron Transport;Enzymes;Equilibrium;Eukaryota;Exhibits;fascinate;frataxin;Friedreich Ataxia;fundamental research;Genetic;Genomic Instability;Health;Human;Human Activities;In Vitro;Individual;insight;Ions;Iron;iron metabolism;Lead;Length;Life;Link;Lipids;Malignant Neoplasms;Mass Spectrum Analysis;Metabolic Diseases;Metabolism;Metalloproteins;Metals;Methods;Mitochondria;Mitochondrial DNA;mitochondrial dysfunction;Modeling;Modification;Molecular Chaperones;molybdenum cofactor;Multiple Sclerosis;Neurodegenerative Disorders;Normal Cell;Parkinson Disease;Pathology;Pathway interactions;Phosphorylation;Post-Translational Protein Processing;Protein Chemistry;protein protein interaction;Proteins;Protomer;Public Health;Reaction;Reactive Oxygen Species;Regulation;Research;Respiration;Role;self assembly;stoichiometry;Structure;Sulfides;Sulfur;System;Time;Tissues;Toxic effect;trafficking;Transfer RNA;Variant

PROJECT_TITLE: Structure and Mechanism of the Human FE-S Cluster Assembly Complex

STUDY_SECTION: MSFA

STUDY_SECTION_NAME: Macromolecular Structure and Function A Study Section[MSFA]


ADMINISTERING_IC: AR

IC_NAME: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

NIH_SPENDING_CATS: Arthritis;Biotechnology;Gene Therapy;Genetics;Osteoarthritis;Physical Injury - Accidents and Adverse Effects;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human

ORG_CITY: ANN ARBOR

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE Post-traumatic osteoarthritis (PTOA) is a type of joint disease that develops after joint injury, and there are currently no effective treatments to halt or reverse this debilitating condition. This research will study whether genetically-modified adult stem cell-derived chondrocytes can block inflammation to slow down the progression of PTOA and determine their mechanism of action. We will inject modified and unmodified stem cells into mouse knee joints after injury and use multiple experimental measures to characterize the potential positive effects of this novel cellular treatment as well as highlight new targets for the treatment of PTOA in mechanistic studies.

PI_NAMEs: COLEMAN, RHIMA  (contact);MAERZ, TRISTAN

PROGRAM_OFFICER_NAME: PINTUCCI, GIUSEPPE

PROJECT_TERMS: Address;adult stem cell;Affect;anterior cruciate ligament rupture;Anti-Inflammatory Agents;Arthralgia;arthropathies;articular cartilage;autocrine;Biological;Biomedical Engineering;Bone remodeling;Cartilage;cartilage degradation;cartilage regeneration;Cell Differentiation process;Cell Separation;Cell Therapy;cell type;Cells;Chondrocytes;chondroprotection;Clinical;clinically relevant;cytokine;Data;Deposition;Development;disability;Disease;Doctor of Philosophy;effective therapy;efficacious treatment;engineered stem cells;Environment;Equilibrium;Exhibits;experimental study;Extracellular Matrix;Female;Fluorescent Probes;Functional disorder;gain of function;Gene Modified;Genes;Genetic;Genetic Engineering;genetically modified cells;Growth Factor;Histologic;Hyperalgesia;Hypertrophy;Image;Immune;Immune response;immunoregulation;improved;In Vitro;in vitro Model;in vivo;in vivo imaging;Inflammation;Inflammatory;inflammatory marker;inflammatory milieu;Injections;Injury;Interleukin-4;joint inflammation;joint injury;Joints;Knee;Knee joint;Label;Luciferases;Macrophage;male;Matrix Metalloproteinases;Measures;Mediating;Mesenchymal;Methods;mid-career faculty;Modality;Modeling;Monitor;mouse model;Mus;Musculoskeletal;next generation;novel;Orthopedic Surgery;Outcome;Pain;paracrine;Pathologic;Pathology;Pathway interactions;Peptide Hydrolases;Phenotype;prevent;Process;Production;professor;Property;Protein Analysis;Randomized;regenerative;Research;Research Personnel;response;runx proteins;Severities;Signal Transduction;Site-Directed Mutagenesis;stem;stem cells;Stromal Cells;structural imaging;Synovial Fluid;Synovitis;Testing;Therapeutic;tissue repair;Tissues;transcription factor;transcriptome sequencing;Traumatic Arthropathy;treatment effect;Undifferentiated

PROJECT_TITLE: Autonomous RUNX2 suppression in genetically modified stem cell-derived chondrocytes as a disease modifying therapeutic for PTOA

STUDY_SECTION: SBSR

STUDY_SECTION_NAME: Skeletal Biology Structure and Regeneration Study Section[SBSR]


ADMINISTERING_IC: HG

ED_INST_TYPE: GRADUATE SCHOOLS

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

NIH_SPENDING_CATS: Genetics;Human Genome;Networking and Information Technology R&D (NITRD)

ORG_CITY: NEW YORK

ORG_NAME: ROCKEFELLER UNIVERSITY

ORG_STATE: NY

PHR: Project Narrative The aim of this proposal is to hold an annual, full-week advanced gene mapping course at The Rockefeller University in New York City. The course is directed towards advanced researchers with knowledge in statistics and genetics and will provide participants with information on the latest methods to identify pathogenic suscptibility variants for complex traits and disease. Thirty- four participants will be admitted to the course and travel stipends will be provided to ten trainees who are either pre-doctoral students or post-doctoral fellows to cover the cost of airfare and hotel.

PI_NAMEs: LEAL, SUZANNE M (contact)

PROGRAM_OFFICER_NAME: RIDER, RENEE ANNE

PROJECT_TERMS: Admission activity;Admixture;base;Basic Science;Biological;Categories;Chromatin;Chromosome Mapping;Clinical;Cloud Computing;Communities;Complex;Complex Genetic Trait;Computer software;Computers;cost;Data;Data Analyses;Data Files;data quality;data tools;Detection;Development;Disabled Persons;Disease;disease diagnosis;Disparity population;doctoral student;Educational process of instructing;epigenomics;Etiology;Exercise;experience;Faculty;Family;Fees;Genes;Genetic;genetic analysis;genetic epidemiology;Genetic Epistasis;Genetic Predisposition to Disease;genome wide association study;Genotype;Heritability;human disease;Human Gene Mapping;improved;instructor;Knowledge;laptop;learning materials;lectures;Libraries;Maps;Mediating;Mediation;Mendelian randomization;Meta-Analysis;Methodology;Methods;Methylation;Minority Groups;Modality;Modeling;New York;New York City;Participant;Pathogenicity;pleiotropism;polygenic risk score;Population;Population Control;Postdoctoral Fellow;power analysis;pre-doctoral;programs;Quality Control;rare variant;Research Personnel;RNA analysis;Running;Sample Size;Sequence Analysis;skills;Slide;statistics;Students;Susceptibility Gene;Testing;theories;tool;Training;trait;transcriptome sequencing;Travel;Universities;Update;Variant;web site;Woman

PROJECT_TITLE: Advanced Gene Mapping Course

STUDY_SECTION: GNOM

STUDY_SECTION_NAME: Genome Research Study Section[GNOM-G]


ADMINISTERING_IC: CA

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL CANCER INSTITUTE

NIH_SPENDING_CATS: Cancer

ORG_CITY: WINSTON-SALEM

ORG_DEPT: BIOLOGY

ORG_NAME: WAKE FOREST UNIVERSITY HEALTH SCIENCES

ORG_STATE: NC

PHR: Project Narrative Cancer is still the second leading cause of death in the US, and many challenges still remain to cure this devastating disease Therefore, it is imperative to establish a sustainable program to train and educate the next generation of scientists and clinicians, who must have broad knowledge and the ability to communicate and work with colleagues. The goal of the proposed Translational Oncology Training program (TOTP) is to ensure that the next generation of cancer researchers are equipped with the tools and knowledge that will enable them to bring bench-top discoveries into clinical trials and vice versa.

PI_NAMEs: PARDEE, TIMOTHY SEBASTIAN;WATABE, KOUNOSUKE  (contact)

PROGRAM_OFFICER_NAME: LIM, SUSAN E

PROJECT_TITLE: Translational Oncology Training Program

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Institutional Training and Education Study Section (F)[NCI-F]


ADMINISTERING_IC: DE

IC_NAME: NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

NIH_SPENDING_CATS: Clinical Research;Dental, Oral, and Craniofacial Disease;Genetics;Human Genome;Microbiome

ORG_CITY: CAMBRIDGE

ORG_NAME: ADA FORSYTH INSTITUTE, INC.

ORG_STATE: MA

PHR: Oral bacteria play a key role in human health and in diseases such as tooth decay and gum disease, and a suspected role in heart disease, stroke and pre-term birth. The proposed research will provide tools, genetic information, and bacterial strains for scientists to understand the interactions between people and their oral bacteria and viruses. Based on this information, health professionals will be better able to understand, prevent, diagnose, and treat diseases caused by oral microbes.

PI_NAMEs: DEWHIRST, FLOYD E;MARK WELCH, JESSICA LEIGH (contact)

PROGRAM_OFFICER_NAME: MCNEALY, TAMARA L

PROJECT_TERMS: Address;Aerodigestive Tract;Animal Model;Bacteria;Bacteriophages;Bibliography;Biochemical;bioinformatics tool;Biological;Biology;Chlorobi;Clinical;Communities;dark matter;Data;Databases;Dental caries;Diagnosis;Disease;experimental study;Foundations;Funding;Genetic;genetic information;Genome;genome resource;genomic data;Genomics;Goals;Health;Health Professional;Heart Diseases;host-microbe interactions;Human;Human Microbiome;improved;In Vitro;in vivo;Investigation;Knowledge;Laboratories;Link;member;Metabolism;metabolomics;metagenome;Metagenomics;Methods;methylome;Microbe;microbial;microbiome;microbiome analysis;microbiome components;microbiome research;Mouth Diseases;Mus;Names;Nose;novel;Oral;oral bacteria;Oral cavity;Oral health;oral microbial community;Oral Microbiology;oral microbiome;Organism;Outcome;Pathogenicity;Persons;Phenotype;Phylogenetic Analysis;Play;preference;Premature Birth;prevent;Proteomics;Radiation;Refractory;Research;Research Personnel;Resources;Ribosomal RNA;Role;Sampling;Scheme;Scientist;Site;Stroke;Structure;Taxon;Taxonomy;Technology;tool;transcriptomics;Treponema;Virus;web-accessible;whole genome

PROJECT_TITLE: A Foundation for the Oral Microbiome and Metagenome

STUDY_SECTION: ODCS

STUDY_SECTION_NAME: Oral, Dental and Craniofacial Sciences Study Section[ODCS]


ADMINISTERING_IC: AG

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Aging;Basic Behavioral and Social Science;Behavioral and Social Science;Clinical Research;Dietary Supplements;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Nutrition;Pediatric;Prevention;Social Determinants of Health

ORG_CITY: ATLANTA

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: EMORY UNIVERSITY

ORG_STATE: GA

PHR: PROJECT NARRATIVE Childhood undernutrition is common in low- and middle-income countries (LMICs), and affects not only child health, but also young adult health, cognition and socioeconomic productivity. The present proposal extends this body of evidence on early nutrition effects to mature adulthood and aging. The potential for childhood nutritional intervention to relieve some of the health, cognitive and socioeconomic declines of later life suggests future benefits for older individuals and their families.

PI_NAMEs: BEHRMAN, JERE R;STEIN, ARYEH DAVID (contact)

PROGRAM_OFFICER_NAME: JAIN, KRITI MUNJAL

PROJECT_TERMS: Adult;Affect;Age;age related chronic disease;age related decline;Age Years;Age-associated memory impairment;Aging;aging brain;Animal Experimentation;Anthropometry;Behavior;Biological Aging;Biological Markers;Biology;Birth Weight;Capital;Central America;Child;Child Health;Childhood;Cognition;Cognitive;Cognitive aging;cognitive function;cognitive skill;cohort;Collaborations;Data;Data Collection;Dietary Intervention;Dimensions;early childhood;early-life nutrition;econometrics;economic outcome;Economics;Effectiveness;Energy Intake;executive function;Family;Female;First Births;fitness;follow-up;Future;Guatemalan;Hand Strength;Health;healthspan;healthy aging;Height;Human;human capital;Impaired cognition;improved;Income;Individual;innovation;inter-institutional;International;Intervention;Investments;Knowledge;late life;Length;Life;Life Cycle Stages;life span;Link;Literature;Liver diseases;low and middle-income countries;male;Malnutrition;Marketing;Measures;member;middle age;Modeling;mortality;next generation;nutrition;Nutritional;Nutritional status;Nutritional Study;nutritional supplementation;Older Population;Only Child;Outcome;Panama;Participant;Personal Satisfaction;Persons;physical conditioning;Play;Population;Pregnancy;Premature aging syndrome;Productivity;productivity loss;programs;protein intake;psychologic;Public Health;Qualifying;Research;Risk;Role;Schools;Sensory;sex;Socioeconomic Status;socioeconomics;Strategic Planning;Stress;Supplementation;Time;United States National Institutes of Health;Wages;Work;young adult

PROJECT_TITLE: The impact of early-life nutrition on socioeconomic status, physical health and cognitive function  through middle age

STUDY_SECTION: SSPA

STUDY_SECTION_NAME: Social Sciences and Population Studies A Study Section[SSPA]


NIH_SPENDING_CATS: Cancer;Colorectal Cancer;Digestive Diseases;Genetics;Liver Disease;Nutrition;Obesity;Prevention

ORG_CITY: COLUMBIA

ORG_DEPT: PATHOLOGY

ORG_NAME: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA

ORG_STATE: SC

PHR: PROJECT NARRATIVE The prevalence of obesity continues to increase in the US and obesity increases the risk of cancer. While it is common practice to apply a dosing cap, current recommendations for the treatment of obese cancer patients is full body surface area chemotherapy dosing regimens despite some evidence suggesting that these patients may have exacerbated drug toxicities. Given that obese individuals are more likely to undergo anti-cancer treatments, there is a need for studying the complex over-lap between obesity and cancer; my proposed study will examine the mechanisms underlying obesity’s impact on the off-target toxicities associated with chemotherapy.

PI_NAMEs: VANDERVEEN, BRANDON  (contact)

PROGRAM_OFFICER_NAME: BOULANGER-ESPEUT, CORINNE A

PROJECT_TERMS: Acute;Address;Anorexia;anti-cancer;anti-cancer treatment;Antineoplastic Agents;Body mass index;Body Surface Area;Body Weight;Breast;Cachexia;Cancer Patient;cancer risk;Cancer Survivor;Cancer Survivorship;cancer therapy;career;Catabolism;Cells;chemotherapy;Circulation;Clustered Regularly Interspaced Short Palindromic Repeats;Colon;colon cancer treatment;Colorectal;Colorectal Cancer;Complex;cytopenia;Cytotoxic Chemotherapy;cytotoxicity;Data;Development;Diet;dietary;Dietary Intervention;dietary manipulation;Dihydropyrimidine Dehydrogenase;Disparity;Dose;Drug Kinetics;drug metabolism;Drug toxicity;enzyme activity;Enzymes;Epidemiology;Excretory function;Fatigue;Fluorouracil;Foundations;Functional impairment;Funding;gene environment interaction;Genetic Variation;Genotype;Goals;Immune;improved;Infection;Inflammation;Inflammatory;Intervention;Investigation;Link;Literature;Liver;Liver Dysfunction;liver function;Macronutrients Nutrition;Malignant Breast Neoplasm;Malignant Neoplasms;Messenger RNA;Metabolism;Mitochondria;Monitor;Mucositis;Mus;Muscle;muscle form;non-alcoholic fatty liver disease;Obese Mice;obese patients;obese person;Obesity;obesity treatment;Pathology;Pathway interactions;Patients;Pharmacodynamics;Pharmacogenetics;Pharmacology;Phase;Phenotype;Physical Function;Physiology;Plasmids;Positioning Attribute;Predisposition;Preparation;Prevalence;primary outcome;Prognosis;Proteins;Proteome;PTPRC gene;Quality of life;Recommendation;Regimen;Research;Risk;Role;Safety;Skeletal Muscle;Support System;targeted treatment;Testing;Therapeutic Index;Thinness;Toxic effect;Training;transcriptome;treatment effect;Treatment Efficacy;Treatment-related toxicity;tumor;Urine;Weight

PROJECT_TITLE: Impact of Obesity on Chemotherapy-Induced Cytotoxicity: Immune Cells and Skeletal Muscle

STUDY_SECTION_NAME: Career Development Study Section (J)[NCI-J]


ORG_CITY: BLOOMINGTON

ORG_NAME: TRUSTEES OF INDIANA UNIVERSITY

ORG_STATE: IN

PHR: PROJECT TITLE: Chemical Biology Studies of the Dynamics and Inhibition of Peptidoglycan Biosynthesis PROJECT NARRATIVE The research proposed in this MIRA application seeks to continue the development of fluorescent D-amino acid (FDAA) probes for detailed study of the dynamics of peptidoglycan (PG) synthesis and bacterial cell division and cell separation. We will also continue our ongoing studies of cyclic peptide antibiotics that inhibit bacterial cell wall biosynthesis, either through direct inhibition of glycan polymerization or through inhibition of lipid recycling. The lipid recycling pathway is not well-defined; its elucidation may reveal novel targets for antibacterial development and provide new opportunities to address the public health threat posed by antibiotic resistance.

PI_NAMEs: VANNIEUWENHZE, MICHAEL S (contact)

PROGRAM_OFFICER_NAME: FABIAN, MILES

PROJECT_TERMS: Address;Amino Acids;Anabolism;Anti-Bacterial Agents;Antibiotic Resistance;Antibiotics;arms race;Bacillus subtilis;Bacteria;bacterial resistance;Biology;Cause of Death;Cell division;Cell Separation;Cell Wall;Cells;Chemicals;Communicable Diseases;Coupled;Cyclic Peptides;Cyclodepsipeptides;Data;Depsipeptides;Development;Lipids;novel;Pathway interactions;Peptide Antibiotics;Peptidoglycan;polymerization;Polymers;Polysaccharides;pressure;programs;Public Health;Recycling;Research;resistant strain;Therapeutic;Time;Visualization software

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-B(55)R]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Data Science;Dementia;Machine Learning and Artificial Intelligence;Networking and Information Technology R&D (NITRD);Neurodegenerative;Neurosciences

ORG_CITY: PHILADELPHIA

ORG_DEPT: RADIATION-DIAGNOSTIC/ONCOLOGY

ORG_NAME: UNIVERSITY OF PENNSYLVANIA

ORG_STATE: PA

PHR: Accurate, time cognitive fast, and robust brain image analysis and pattern recognition methods will be developed for real- neuroimaging data analysis and computer aided prognosis of Alzheimer's disease dementia and decline.

PI_NAMEs: FAN, YONG  (contact)

PROGRAM_OFFICER_NAME: HSIAO, JOHN

PROJECT_TERMS: Adopted;Aging;Algorithms;Alzheimer's Disease;Alzheimer's disease diagnosis;Alzheimer's disease model;Anatomy;Brain;brain based;Brain imaging;brain morphology;Brain scan;brain tissue;Clinical;cluster computing;Cognitive;Computer Assisted;Computer software;Consumption;convolutional neural network;cost;Data;Data Analyses;Data Set;deep learning;deep learning algorithm;Dementia;Development;disease prognosis;Disease Progression;Ensure;Environment;Event;graph neural network;High Performance Computing;Hour;Image;Image Analysis;image processing;image registration;imaging Segmentation;Imaging technology;Impaired cognition;improved;Individual;Intervention;Knowledge;large scale data;large-scale imaging data;Learning;Machine Learning;Magnetic Resonance Imaging;Maps;Measures;Medicine;Methods;mild cognitive impairment;Modeling;Neurodegenerative Disorders;neuroimaging;non-invasive imaging;novel;open source;Pattern Recognition;Pennsylvania;Performance;Persons;portability;pre-clinical;predictive modeling;Prognosis;prognostic model;programs;reconstruction;Research;Research Personnel;Resources;Risk;Scanning;segmentation algorithm;Source Code;Speed;Structure;supervised learning;Surface;Techniques;Time;tool;Translations;Universities;user-friendly;web app

PROJECT_TITLE: Fast and robust deep learning tools for analysis of neuroimaging data of Alzheimer's disease

STUDY_SECTION: EITN

STUDY_SECTION_NAME: Emerging Imaging Technologies in Neuroscience Study Section[EITN]


NIH_SPENDING_CATS: Cancer;Clinical Research;Clinical Trials and Supportive Activities;Comparative Effectiveness Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Orphan Drug;Patient Safety;Rare Diseases

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Project Narrative Participation of patients and investigators in National Clinical Trials Network (NCTN) clinical trials is vital to our understanding of the biology and treatment of cancer. Support of NCTN leadership activities of Duke faculty and clinical research staff effort will help us maintain our high patient enrollment and robust scientific participation in clinical trials of national importance.

PI_NAMEs: BARBORIAK, DANIEL P;CRAWFORD, JEFFREY ;ERBA, HARRY PAUL;HWANG, E. SHELLEY ;KELSEY, CHRISTOPHER ;SECORD, ANGELES ALVAREZ;SUTTON, LINDA ;THOMAS, ALEXANDRA  (contact)

PROGRAM_OFFICER_NAME: MOONEY, MARGARET M

PROJECT_TERMS: Administrative Efficiency;Adolescent;Adolescent and Young Adult;Adult;American College of Radiology Imaging Network;anti-cancer research;Applications Grants;Award;Biology;cancer care;cancer therapy;Cancer Trials Support Unit;Clinical;Clinical Investigator;Clinical Research;Clinical Treatment;clinical trial recruitment;Clinical Trials;Clinical Trials Network;Combined Modality Therapy;Communities;community based practice;Complex;Conduct Clinical Trials;Dedications;Development;Disease;Early Therapeutic-Clinical Trials Network;Eastern Cooperative Oncology Group;Enrollment;Environment;Evaluation;experience;Faculty;faculty research;Financial Support;Fostering;Funding;Future;Goals;Grant;Image;imaging approach;Imaging Techniques;Immune;improved;Infrastructure;Institution;Interdisciplinary Study;Investigation;Knowledge;Lead;Leadership;Malignant Childhood Neoplasm;Malignant Neoplasms;medical schools;member;Mentors;Minority;Modality;Molecular;Multiple Cancer Sites;Names;National Clinical Trials Network;next generation;novel;Oncology;organizational structure;participant enrollment;Patient Participation;patient population;Patients;Phase;Physicians;pilot trial;Principal Investigator;programs;rare cancer;Research;Research Personnel;Resources;Role;scientific organization;Site;Southwest Oncology Group;Special Population;Structure;Therapeutic Trials;therapy development;Training;treatment trial;trial design;underserved community;Underserved Population;Universities;Vertebral column;young adult

PROJECT_TITLE: NCI National Clinical Trials Network (UG1)


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Genetics;Human Genome;Neurodegenerative;Neurosciences;Patient Safety;Regenerative Medicine;Stem Cell Research;Stem Cell Research - Nonembryonic - Non-Human

ORG_CITY: Los Angeles

ORG_DEPT: PHYSIOLOGY

ORG_NAME: UNIVERSITY OF SOUTHERN CALIFORNIA

PHR: PROJECT NARRATIVE  Age is the major risk factor for most chronic human diseases, including Alzheimer’s disease. There is a vital need to develop new approaches to rejuvenate the brain and improve cognition. This research should provide important information that can be used to discover new anti-aging therapies.

PI_NAMEs: BONAGUIDI, MICHAEL  (contact)

PROGRAM_OFFICER_NAME: DIBATTISTA, AMANDA

PROJECT_TERMS: adult neurogenesis;Age;age related changes;Aging;aging hippocampus;Alzheimer's Disease;Animals;anti aging;behavioral study;Brain;Cell Aging;Cell Reprogramming;Cells;Chronic;Cognition;cognitive reserve;Country;Data;gene network;Goals;Government Agencies;Health;human disease;improved;insight;Institution;Intervention;Legal;Mediating;Memory;Molecular;Monitor;Names;nerve stem cell;neurogenesis;novel strategies;old mice;performance site;Pharmacogenomics;Procedures;programs;Regenerative capacity;Regenerative Medicine;Rejuvenation;Research;resilience;Resources;Risk Factors;Security;Societies;stem cell aging;stem cell fate;stem cell function;stem cell proliferation;Systems Biology;Techniques;transcriptomics;Work

PROJECT_TITLE: Neural stem cell rejuvenation through single cell pharmacogenomics


NIH_SPENDING_CATS: Anxiety Disorders;Basic Behavioral and Social Science;Behavioral and Social Science;Bioengineering;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Mental Health;Mental Illness;Neurosciences;Schizophrenia

ORG_DEPT: PSYCHOLOGY

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project Narrative The proposed research is relevant to public health because it will elucidate the computational and neural bases of metacognition thus leading to improved assessment and treatment for people with disorders characterized by metacognitive impairments such as schizophrenia, depression, generalized anxiety disorder, and obsessive- compulsive disorder. Thus, the proposal is relevant to NIH’s mission of developing fundamental knowledge that can be applied to reduce the burden of human disability.

PI_NAMEs: RAHNEV, DOBROMIR  (contact)

PROGRAM_OFFICER_NAME: VAZIRI, SIAVASH

PROJECT_TERMS: adjudication;Affect;Aging;Architecture;Back;base;Bayesian Modeling;Behavior;Behavioral;Biological Models;Brain;Clinic;Communication;Computer Models;Data;Decision Making;Dependence;disability;Disease;Effectiveness;effectiveness evaluation;Functional disorder;generalized anxiety;Generalized Anxiety Disorder;Generations;Goals;Human;Impairment;improved;insight;Investigation;Judgment;Knowledge;Lesion;Link;Measurement;Measures;Mental Depression;Mental disorders;metacognition;Middle frontal gyrus structure;Mission;Modeling;neural;Noise;novel;Obsessive-Compulsive Disorder;Outcome;Participant;Patients;Persons;Positioning Attribute;Property;Psychometrics;Public Health;Research;Research Personnel;Risk Behaviors;Role;Schizophrenia;Sensory;Source;Stimulus;Structure;Substance abuse problem;Symptoms;system architecture;Techniques;Testing;tool;Treatment Effectiveness;United States National Institutes of Health;Validation;Visual;Work

PROJECT_TITLE: Uncovering the Architecture of Metacognition

STUDY_SECTION: CP

STUDY_SECTION_NAME: Cognition and Perception Study Section[CP]


ORG_CITY: HOUSTON

ORG_DEPT: MICROBIOLOGY/IMMUN/VIROLOGY

ORG_NAME: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON

PHR: Narrative The fungus Candida albicans causes significant morbidity and mortality in the United States, particularly among individuals that have a weakened immune system such as cancer patients undergoing chemotherapy or transplant recipients. Using animal models of Candida colonization and infection, my laboratory has uncovered fungal regulatory genes that are key determinants of the Candida-host interplay. We will study of these regulatory systems, their associated traits and the molecular mechanisms whereby they effect the interactions with mammalian cells.

PI_NAMEs: PEREZ, JOSE CHRISTIAN (contact)

PROGRAM_OFFICER_NAME: LOVE, DONA

PROJECT_TERMS: Adherence;Adhesions;Animal Model;Apical;Applications Grants;Automobile Driving;Binding;biological adaptation to stress;Biology;Blood Circulation;Cancer Patient;Candida;Candida albicans;Candidate Disease Gene;Cells;Chemicals;chemotherapy;Colon;Cues;Data;Disease;Disparate;ena protein;Environment;Epithelium;Event;extracellular;fitness;fungal genetics;fungus;gene product;Genes;genetic approach;Genetic Determinism;Genetic Screening;Genetic Transcription;Gnotobiotic;Goals;Growth;gut colonization;gut microbiota;Homeostasis;host colonization;Human;Immune system;Individual;Infection;Intestinal Mucosa;Intestines;Laboratories;Learning;Life;Link;Mammalian Cell;Mediating;member;Messenger RNA;Microbe;Modeling;Molecular;Morbidity - disease rate;mortality;mouse model;Mucous body substance;Mucous Membrane;Mus;neutrophil;Nitrogen;novel;Nutrient;Organ;Organelles;Oropharyngeal;oropharyngeal thrush;Oxidative Stress;pathobiont;Phosphoric Monoester Hydrolases;Phosphorylation;Phosphotransferases;Physiology;Process;Production;Program Description;programs;Proliferating;Publishing;Reaction;reconstitution;Regulation;Regulator Genes;Research;Role;Shapes;Signal Transduction;Signaling Molecule;Site;Sphingolipids;Surface;System;Technology;Tissues;trait;transcriptome sequencing;Transplant Recipients;United States;Vacuole;Work

PROJECT_TITLE: Fungal regulatory systems directing mammalian host colonization

STUDY_SECTION: PTHE

STUDY_SECTION_NAME: Pathogenic Eukaryotes Study Section[PTHE]


PHR: NARRATIVE Antibiotic resistant bacteria are a growing crisis that not only threaten our ability to treat infections but also advances of modern medicine that rely on antibiotics, such as transplants, chemotherapy and even routine surgeries. Heteroresistance is an underappreciated and emerging form of antibiotic resistance which is poorly understood. The Heteroresistance Interdisciplinary Research Unit (HR-IRU) will elucidate the mechanisms causing heteroresistance, its dynamics and prevalence among clinical isolates, leading to translational interventions to improve human health.

PI_NAMEs: LEVIN, BRUCE RICHARD;WEISS, DAVID S (contact)

PROGRAM_OFFICER_NAME: ERNST, NANCY L

PROJECT_TERMS: Acinetobacter baumannii;Address;Affect;anti-fungal agents;Antibiotic Resistance;antibiotic resistant infections;Antibiotic Therapy;Antibiotics;Bacteria;Bacterial Antibiotic Resistance;Bacterial Infections;Bacterial Physiology;bacterial resistance;base;carbapenem resistance;carbapenem-resistant Enterobacteriaceae;Cells;Cessation of life;chemotherapy;Clinic;Clinical;clinical diagnostics;Colistin;combat;Combined Modality Therapy;cost;Data;design;Detection;Development;Diagnostic;Diagnostic tests;effective therapy;Epidemic;Epidemiology;Eukaryota;Exhibits;experimental study;extreme prematurity;FDA approved;fighting;Foundations;Frequencies;Genetic;Health;Heterogeneity;Human;improved;in vivo;in vivo Model;Individual;Infection;insight;Interdisciplinary Study;Intermediate resistance;Intervention;Knowledge;Learning;Life;Longitudinal trends;Malignant Neoplasms;Mediating;Medical;Metabolic;Microscopy;Modeling;Modern Medicine;Molecular;mortality;Mus;Mutation;novel strategies;novel therapeutics;Operative Surgical Procedures;Patients;Pharmaceutical Preparations;Phenotype;Population;Predisposition;Prevalence;prevent;Prokaryotic Cells;Reporting;Research;Resistance;resistance mechanism;resistant strain;Risk;single cell analysis;surveillance data;Therapeutic;Time;trait;Transplantation;Treatment Failure;Work


PHR: PROJECT NARRATIVE In accordance with RFA-AI-20-001, the project narrative should not be completed for the Administrative Core.

PI_NAMEs: WEISS, DAVID S (contact)

PROJECT_TERMS: Agreement;Antibiotic Resistance;Awareness;base;Collaborations;Communication;Communities;conflict resolution;data management;data sharing;design;Ensure;Goals;Infrastructure;Institution;Intellectual Property;Interdisciplinary Study;Intermediate resistance;International;Logistics;material transfer agreement;meetings;National Institute of Allergy and Infectious Disease;operation;outreach;Prevalence;Process;Productivity;programs;Property Rights;Recording of previous events;Research;Research Personnel;Research Project Grants;Structure;symposium;U-Series Cooperative Agreements;United States National Institutes of Health;Universities;videoconference

PROJECT_TITLE: Heteroresistance Interdisciplinary Research Unit (Admin Core)


ADMINISTERING_IC: DC

IC_NAME: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Dental, Oral, and Craniofacial Disease;Neurosciences;Nutrition

ORG_CITY: WALTHAM

ORG_NAME: BRANDEIS UNIVERSITY

PHR: When a taste is placed on our tongues, we must decide whether to push it to the back for swallowing or to the front for ejecting, a decision that depends on our experience with the taste -- the process that involves the amygdala and cortex, whereby we learn to reject a potentially harmful taste. While these two forebrain structures are known to be reciprocally connected, and this connection is vital for learning, little is known about how amygdala and cortex work together to make learning happen. The work proposed in this grant will answer this question, testing whether and how activity in the amygdala-cortical pathway enables cortical neurons to make the response changes that are necessary for learning, and also provide a more systemic understanding of taste learning which will help us to develop tools to aid parents with a wide range of child feeding issues, and to cure vexing taste abnormalities such as develop during pregnancy.

PI_NAMEs: KATZ, DONALD B (contact)

PROGRAM_OFFICER_NAME: SABRI, MERAV

PROJECT_TERMS: Acute;Affect;Amygdaloid structure;Automobile Driving;Axon;Back;Behavior;Brain region;Cells;Child;Code;Collaborations;Complex;conditional knockout;Coupling;Data;Deglutition;designer receptors exclusively activated by designer drugs;Development;Electrophysiology (science);experience;experimental study;feeding;follow-up;Foundations;Genes;Genetic;Genetic Transcription;Grant;Human;Impairment;Individual;Interneurons;Investigation;Knockout Mice;Learning;Link;Maintenance;Mammals;memory retrieval;Mind;Molecular;Mus;neural;neuromechanism;neuronal excitability;Neurons;Neurophysiology - biologic function;Optics;Parents;Pathway interactions;Perception;Perceptual learning;Play;Population;Pregnancy;Process;Progress Reports;Prosencephalon;Rattus;Research;response;Role;Saccharin;Structure;Synapses;System;Taste aversion;Taste Perception;Testing;Time;Tongue;tool;Training;transmission blocking;Vertebrates;Viral;Work

PROJECT_TITLE: Amygdala-cortical interactions in taste perception and learning

STUDY_SECTION: LAM

STUDY_SECTION_NAME: Neurobiology of Learning and Memory Study Section[LAM]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

PHR: PROJECT NARRATIVE In accordance with RFA-AI-20-001, the project narrative should not be completed for the scientific core.

PI_NAMEs: JACOB, JESSE THOMAS (contact)

PROJECT_TERMS: Acinetobacter;Acinetobacter baumannii;Age;Antibiotic Resistance;Antibiotics;Area;biobank;Blood Circulation;Board Certification;carbapenem resistance;Centers for Disease Control and Prevention (U.S.);Characteristics;Clinical;Clinical Microbiology;Collection;Communicable Diseases;Complex;Data;Descriptive Epidemiology;Emerging infection;Enterobacter;Enterobacteriaceae;Epidemiologist;Epidemiology;Escherichia;Funding;Genetic;Genotype;Goals;Healthcare;Infection;Interdisciplinary Study;Intermediate resistance;Klebsiella;Knowledge;Laboratories;Leadership;Link;longitudinal analysis;Medical;Medical Device;Metabolic;Methodology;Methods;multi-drug resistant pathogen;multidisciplinary;novel;operation;Patient Care;Pattern;Population Analysis;population based;Predisposition;Prevalence;Process;programs;prospective;prospective test;Publications;Race;Reproducibility;Research;Research Project Grants;respiratory;Risk Factors;Scientist;sex;Site;Standardization;statistics;success;Sweden;Syndrome;Testing;trend;Universities;University Hospitals;Urine;Work

PROJECT_TITLE: Clinical Isolate Core (Core B)


ED_INST_TYPE: HOSPITALS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Bioengineering;Biomedical Imaging;Brain Disorders;Clinical Research;Data Science;Dementia;Neurodegenerative;Neurosciences;Precision Medicine;Prevention

ORG_NAME: UNIVERSITY OF TX MD ANDERSON CAN CTR

PHR: This research seeks to develop innovative statistical methods for, and address several gaps in, the longitudinal analysis of heterogeneous and high-dimensional neuroimaging and -omics data, combined with clinical and demographic features, towards the ultimate goal of advancing precision medicine for Alzheimer's Disease (AD). The primary goal is to build predictive models for disease progression in AD that incorporates unknown interactions between imaging and -omics features as well as supplementary information such as gene pathways, while accounting for heterogeneity resulting from observed as well as latent confounders. To our knowledge, our project is one of the first to develop a sophisticated integrative statistical framework for studying the trajectory of disease progression in AD using longitudinal cognitive and brain imaging data and baseline clinical, and -omics data, which provides valuable computational tools for early detection in AD that is of tremendous clinical importance in delivering patent centric outcomes.

PI_NAMEs: KUNDU, SUPRATEEK  (contact);LONG, QI

PROJECT_TERMS: Address;Algorithms;Alzheimer's Disease;Alzheimer's disease model;Anatomy;Atrophic;Automobile Driving;Bayesian Method;Biological;Biological Markers;Biomedical Research;Brain;Brain imaging;brain shape;cerebral atrophy;Clinical;Clinical Data;clinical predictive model;Cognition;Cognitive;Communities;Complex;computerized tools;Data;data integration;Data Set;Demographic Factors;Dependence;design;Development;Disease;disease model;disease prognosis;Disease Progression;disorder risk;DNA Sequence Alteration;Early Diagnosis;Etiology;Future;Genes;Goals;Guidelines;Heterogeneity;high dimensionality;high risk population;Image;Individual;innovation;insight;Joints;Legal patent;Literature;longitudinal analysis;longitudinal dataset;Longitudinal Studies;markov model;Methodology;Methods;Modality;Modeling;Molecular;Molecular Profiling;MRI Scans;multidimensional data;multimodality;neuroimaging;neuroimaging marker;novel;open source;Outcome;Pathway interactions;Pattern;personalized predictions;Phase;Phenotype;Population;precision medicine;predictive modeling;prognostic;Property;Recommendation;Research;Resolution;risk prediction;Scanning;Severity of illness;Signal Transduction;simulation;Software Tools;Statistical Methods;Statistical Models;Study models;Surface;Testing;therapeutic target;Time;tool;Training;training data;Translational Research;user-friendly;Validation;Visit;Work

PROJECT_TITLE: Statistical Modeling of Alzheimer's Disease Progression Integrating Brain Imaging and -Omics Data

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-PSE-B(02)]


PI_NAMEs: KIM, MINSU  (contact)

PROJECT_TERMS: Antibiotics;Area;Bacteria;Bioreactors;Cell Maintenance;Cells;Clinical;Complement;Controlled Environment;Copy Number Polymorphism;Devices;Ensure;Environment;experimental study;Fiber;Fluorescence;fluorescence microscope;Fluorescent in Situ Hybridization;Fluorescent Probes;Gene Amplification;Gene Dosage;Gene Expression Profiling;Genotype;glucose metabolism;Glutathione Metabolism Pathway;Goals;Heterogeneity;Image;Image Analysis;Individual;Interdisciplinary Study;interest;Intermediate resistance;Laboratories;Length;Measures;Metabolic;Metabolism;Methods;Microfluidics;Monitor;Nutrient;Physics;Physiology;Population;Prevalence;Process;Reporter;Research;resistance gene;Resolution;Scientist;single cell analysis;single molecule;Statistical Data Interpretation;Time;Universities;Variant;Waste Products;Work

PROJECT_TITLE: Single Cell Analysis Core (Core C)


NIH_SPENDING_CATS: Biotechnology;Genetics

ORG_CITY: SEATTLE

ORG_NAME: UNIVERSITY OF WASHINGTON

ORG_STATE: WA

PHR: Narrative RAS is a central component of many intracellular signaling networks in eukaryotes. Despite the role of mis- regulated RAS in numerous cancers, many fundamental aspects of RAS-mediated signaling are still poorly understood. Here, we will quantitatively characterize the dynamics of RAS-driven signaling in different cellular environments and explore the effects of signaling crosstalk.

PI_NAMEs: MALY, DUSTIN J (contact)

PROGRAM_OFFICER_NAME: HARTON, MARIE DEBORAHGAYNELLE

PROJECT_TERMS: Address;Affect;Behavior;Behavior Control;Binding;Biology;Cancer cell line;Cell Physiology;Cells;chemical genetics;Chemicals;Clinical;Complex;Development;dimer;Dimerization;Dose;Environment;Enzymes;Eukaryota;Feedback;Generations;genetic analysis;GTP Binding;Guanosine Triphosphate Phosphohydrolases;inhibitor;inhibitor therapy;insight;interest;Investigation;kinase inhibitor;KRAS oncogenesis;Location;Malignant Neoplasms;Mammalian Cell;Mediating;MEKs;Methods;migration;Molecular;mutant;novel;Oncogenic;Output;Pathway interactions;Permeability;phosphoproteomics;Phosphotransferases;Play;Process;Proliferating;Protein Isoforms;Proteins;Proteomics;RAS genes;RAS inhibition;Ras Inhibitor;recruit;Resistance;response;Role;Signal Pathway;Signal Transduction;small molecule;spatiotemporal;System;T-Cell Development;Technology;technology platform;Time;tool;trafficking;transcriptomics;Work

PROJECT_TITLE: Chemical Genetic Analysis of RAS Signaling

STUDY_SECTION: SBCA

STUDY_SECTION_NAME: Synthetic and Biological Chemistry A Study Section[SBCA]


NIH_SPENDING_CATS: Biotechnology;Breast Cancer;Cancer;Cancer Genomics;Clinical Research;Genetics;Human Genome;Immunotherapy;Women's Health Research

ORG_CITY: BOSTON

ORG_NAME: DANA-FARBER CANCER INST

PHR: Project Narrative CDK4/6 inhibition in CD8 T cells augments long-term protective immunity by skewing CD8 T cells toward a memory fate. A basic understanding of the mechanistic role of CD4/6 in CD8 T cell fate decisions will allow for better design of clinical trials in cancer or infectious disease using CDK4/6i as adjuvants to promote CD8 T cell memory.

PI_NAMEs: DOUGAN, STEPHANIE  (contact)

PROGRAM_OFFICER_NAME: MALLIA, CONRAD M

PROJECT_TERMS: Achievement;Adjuvant;Adoptive Transfer;Affect;Affinity;Antigens;ATAC-seq;Binding;Binding Sites;Blood;Blood Cells;Blood specimen;blood treatment;Breast Cancer Patient;Breast Cancer Treatment;cancer immunotherapy;Cancer Patient;CD8-Positive T-Lymphocytes;CD8B1 gene;CDK4 gene;Cell Cycle;Cell Cycle Regulation;Cell division;Cell Lineage;Cells;ChIP-seq;Chromatin;chromatin immunoprecipitation;Circulation;Clinic;Clinical;Clinical Trials;Clinical Trials Design;Co-Immunoprecipitations;Communicable Diseases;cytokine;Cytostatics;Data;Destinations;Development;Disease remission;DNA;drug action;Effector Cell;G1 Arrest;Gene Expression;Gene Expression Profile;Gene Expression Profiling;Gene Silencing;Genes;Genetic Transcription;Goals;Hepatitis;Heterogeneity;Human;immune checkpoint blockade;Immunity;Immunologics;Immunoprecipitation;Immunotherapeutic agent;improved;In Vitro;in vivo;Individual;inhibitor;inhibitor therapy;Link;long term memory;Malignant Neoplasms;Mass Spectrum Analysis;Memory;Minority;Modeling;Molecular;mouse model;Mus;Nature;neoplastic cell;Nuclear;Paper;patient safety;Patients;PD-1 blockade;Pharmaceutical Preparations;phase I trial;phase II trial;Phosphorylation;Physiological;Positioning Attribute;prevent;Proteins;Reporting;Resolution;response;RNA;Role;RUNX3 gene;Sampling;Seminal;single-cell RNA sequencing;T cell therapy;T memory cell;T-Cell Activation;T-Lymphocyte;Technology;Testing;therapy design;Tissue Sample;Tissues;Toxic effect;transcription factor;Transcription Repressor;tumor;tumor growth;Tumor Immunity;Up-Regulation

PROJECT_TITLE: CDK4/6 inhibition during CD8 T cell priming potentiates memory formation in mice and humans

STUDY_SECTION: CMIA

STUDY_SECTION_NAME: Cellular and Molecular Immunology - A Study Section[CMIA]


NIH_SPENDING_CATS: Antimicrobial Resistance;Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

PHR: PROJECT NARRATIVE In accordance with RFA-AI-20-001, the project narrative should not be completed for the research project.

PI_NAMEs: ANDERSSON, DAN  (contact)

PROJECT_TERMS: Acinetobacter baumannii;Acute;Address;Aftercare;Algorithms;Animals;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Back;Bacteria;bacteria classification;bacterial resistance;behavior influence;Biological;Cells;Clinical;Clinical Microbiology;Clinical Research;clinically relevant;Collection;combat;Copy Number Polymorphism;cost;Data;design;Detection;efflux pump;Enterobacter;Enterobacteriaceae;Escherichia coli;Evolution;Exhibits;experimental study;fitness;Frequencies;Gene Amplification;Generations;Genes;Genetic;genetic analysis;genetic testing;Genome;genome sequencing;Gram-Negative Bacteria;improved;In Vitro;Infection;Interdisciplinary Study;Intermediate resistance;Klebsiella pneumoniae;mathematical model;Modeling;novel strategies;novel therapeutics;Pap smear;Pharmaceutical Preparations;Phenotype;Physiological;Population;Population Analysis;Predisposition;pressure;Process;Property;recurrent infection;Research Project Grants;Resistance;resistance gene;resistance mechanism;screening;Sequence Analysis;Signal Transduction;Sweden;tool;trait;Treatment Failure;Treatment outcome;whole genome;Work

PROJECT_TITLE: Project 1: Mechanisms, Dynamics, and Prediction of Heteroresistance


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PROVIDENCE

ORG_NAME: BROWN UNIVERSITY

ORG_STATE: RI

PHR: This is the second renewal application of the Alpert Medical School Summer Research Program (AMSSRP). The  overall goal of the AMSSRP is to provide  12  medical students with the opportunity to have a mentored research experience annually under the guidance of Brown University faculty. Designated faculty trainers are the principal investigators for research programs focused on the molecular basis and pathology of cardiovascular, pulmonary, and blood diseases and/or disease outcomes and prevention. The current program offers 8 medical students, who have just completed their 1  year of medical school, a 9 week summer research st experience that includes a collaborative, multidisciplinary, mentored research project, didactic training, and career development activities to enhance their understanding, and give them the hands-on experience of a career as a physician-scientist. The AMSSRP is geared to expose students to the critical role played by physician-scientists in translational research and to inspire these students to embark on this career path of exploration and discovery.

PI_NAMEs: BARTNIKAS, THOMAS BENEDICT;HAMPTON, BRITTANY STAR;HARRINGTON, ELIZABETH O (contact);MORRISON, ALAN ROSS

PROGRAM_OFFICER_NAME: MEADOWS, TAWANNA

PROJECT_TERMS: Basic Science;bench-to-bedside translation;Biomedical Research;Blood;Cardiovascular Diseases;Cardiovascular Pathology;Cardiovascular system;career;Career Choice;career development;Clinical Competence;Consumption;Diagnostic;Disease;Disease Outcome;disorder prevention;Disparity;Doctor of Philosophy;Education;efficacious treatment;experience;Exposure to;Faculty;Goals;Health;Hematological Disease;Hospitals;human disease;knowledge base;Learning;Length;Lung;Lung Diseases;Medical Care Costs;medical schools;Medical Students;Mentors;Mentorship;Molecular;multidisciplinary;Perception;Physicians;Play;Principal Investigator;programs;Research;Research Project Grants;Role;Scientific Inquiry;Scientist;skills;Students;summer research;Time;Training;Translational Research;trend;United States National Institutes of Health;Universities


NIH_SPENDING_CATS: Anxiety Disorders;Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Depression;Major Depressive Disorder;Mental Health;Mental Illness;Neurosciences;Serious Mental Illness

ORG_CITY: TULSA

ORG_NAME: LAUREATE INSTITUTE FOR BRAIN RESEARCH

ORG_STATE: OK

PHR: PROJECT NARRATIVE Epidemiological data strongly suggest worse treatment burden and outcomes for comorbid anxiety and depression (AD-MDD) than depression (MDD) alone, but these groups are often collapsed in mechanistic studies and clinical trials. Our pilot data suggest striking differences between AD-MDD and MDD on multiple measures of threat sensitivity but it is unclear if these differences are in “acute threat/fear” or “sustained threat/anxiety”. The present study seeks to delineate threat sensitivity between AD-MDD, MDD and AD in terms of “fear” and “anxiety” using electromyography, fMRI and an acute pharmacological manipulation to establish circuit based treatment targets for AD-MDD.

PI_NAMEs: IRONSIDE, MARIA  (contact)

PROGRAM_OFFICER_NAME: WIJTENBURG, SARAH ANDREA

PROJECT_TERMS: Acute;Address;Agonist;Amygdaloid structure;Anti-Anxiety Agents;Anxiety;Anxiety Disorders;Behavioral;behavioral response;Benzodiazepines;Blinking;burden of illness;Clinical Trials;comorbidity;Complex;Crossover Design;Data;Depressive disorder;Disease;Dose;Electromyography;Electrophysiology (science);epidemiologic data;Exhibits;Fright;Functional disorder;Functional Magnetic Resonance Imaging;Future;gamma-Aminobutyric Acid;Goals;Hippocampus;Impairment;Individual;Insula of Reil;Intervention;Literature;Lorazepam;Major Depressive Disorder;Measures;Medicine;Mental Depression;midbrain central gray substance;Modeling;Morbidity - disease rate;mortality;Multimodal Imaging;neural;neural circuit;Neurologic;neuromechanism;neuroregulation;novel;Outcome;Participant;Patient Self-Report;Persons;pharmacologic;Physiological;Placebos;Prefrontal Cortex;Process;Relapse;Research;Resistance;response;Rewards;Severities;Shock;suicidal risk;System;therapy resistant;Treatment outcome

PROJECT_TITLE: Processes and circuitry underlying threat sensitivity as a treatment target for comorbid anxiety and depression

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BP-R(02)M]


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurosciences

ORG_CITY: MADISON

ORG_NAME: UNIVERSITY OF WISCONSIN-MADISON

ORG_STATE: WI

PHR: Narrative Neural circuit health and function rely on the active transport of mitochondria and maintenance of their health. Disruption of mitochondrial transport and deficits in mitochondrial health are associated with neurodegenerative diseases including Alzheimer’s disease. This application proposes to investigate the molecular regulation of mitochondrial transport and the role this process has in the maintenance of a healthy mitochondrial population in neurons to better define the pathology and therapeutic pathways relevant to neurodegenerative disease.

PI_NAMEs: DRERUP, CATHERINE M (contact)

PROGRAM_OFFICER_NAME: TYLER, WILLIAM A

PROJECT_TERMS: Active Biological Transport;Adaptor Signaling Protein;Address;aged;Alzheimer's Disease;anterograde transport;Apoptotic;Axon;Binding;Biogenesis;Biological;Biological Assay;Biology;Biosensor;Calcium;Cardiolipins;Cell Culture Techniques;Cell Physiology;Cells;Cellular biology;Data;Defect;design;Disease;Dynein ATPase;Endoplasmic Reticulum;Eukaryotic Cell;experimental study;fascinate;Genetic;Genetic Screening;Goals;Health;Homeostasis;Hour;Human;Image;imaging approach;In Vitro;in vivo;in vivo imaging;Individual;Induced pluripotent stem cell derived human neuron;insight;Iron;Knowledge;Label;Life;Link;Lipid Binding;Lipids;Maintenance;Mediating;Metabolic;meter;Mitochondria;Molecular;Motor;mutant;Mutate;neural circuit;Neurodegenerative Disorders;neuroimaging;neuronal cell body;neuronal survival;Neurons;Organelles;Organism;Outer Mitochondrial Membrane;Pathology;Pathway interactions;Patients;Population;Positioning Attribute;Process;Production;Proteins;Proteome;Protocols documentation;Recycling;Regulation;retrograde transport;Role;Signal Transduction;Signaling Molecule;Site;Source;System;Testing;Therapeutic;Therapeutic Intervention;tool;transcriptome;Transgenic Organisms;Work;Zebrafish

PROJECT_TITLE: Mechanism and function of retrograde mitochondrial transport in axons

STUDY_SECTION: SYN

STUDY_SECTION_NAME: Synapses, Cytoskeleton and Trafficking Study Section[SYN]


ADMINISTERING_IC: TW

IC_NAME: FOGARTY INTERNATIONAL CENTER

NIH_SPENDING_CATS: Behavioral and Social Science;Clinical Research;HIV/AIDS

ORG_CITY: DURBAN

ORG_COUNTRY: SOUTH AFRICA

ORG_FIPS: SF

ORG_NAME: UNIVERSITY OF KWAZULU-NATAL

PHR: PROJECT NARRATIVE This is an application for the funding of a dedicated Masters program on research ethics, with a focus on developing legal capacity on research ethics committees (RECs). Graduates of the program will be equipped with the academic knowledge and practical skills needed to contribute to strengthening both teaching of and research into research ethics in Africa. Graduates will also have the skills to participate as members of RECs thus facilitating enhanced regulation of health research in Africa.

PI_NAMEs: ESSACK, ZAYNAB ;STRODE, ANN ELAINE (contact)

PROGRAM_OFFICER_NAME: SINA, BARBARA J

PROJECT_TERMS: Acquired Immunodeficiency Syndrome;Address;Africa;African;Bioethics;career;Child;Committee Members;Communities;Complex;Country;Critical Thinking;Dedications;Development;Doctor of Philosophy;Education;educational atmosphere;Educational Curriculum;Educational process of instructing;Educational workshop;Enrollment;Ethical Issues;Ethics;Faculty;Fostering;Foundations;Funding;Guidelines;Health;Health Professional;Home;Human;Incentives;Individual;Institution;Institutionalization;Knowledge;Laws;Lawyers;Leadership;Learning;Legal;meetings;member;Mentors;Mentorship;Methodology;Morals;multidisciplinary;novel;online community;Outcome;Paper;Peer Review;peer support;Persons;Philosophy;programs;Publications;Regulation;Research;research and development;Research Contracts;Research Design;Research Ethics;Research Ethics Committees;Research Methodology;Research Personnel;Research Project Grants;Role;Scholarship;Science;Site Visit;skill acquisition;skills;Social Sciences;Solid;South Africa;South African;Structure;Students;symposium;Training;Training Programs;United States National Institutes of Health;Universities;virtual;Work;Writing

PROJECT_TITLE: South African Research Ethics Training Initiative


PROJECT_TERMS: Acinetobacter baumannii;Affect;alpha ketoglutarate;Antibiotic Resistance;antibiotic resistant infections;Antibiotics;Bacteria;Bacterial Infections;bacterial resistance;Biology;carbapenem-resistant Enterobacteriaceae;Cells;Cessation of life;chemotherapy;Citric Acid Cycle;Classification;Clinic;Clinical;clinical diagnostics;Clinical Trials;combat;Complement;Confusion;design;Diffusion;drug development;Enterobacter;Enterobacteriaceae;Europe;Exhibits;experimental study;Formulation;Fosfomycin;Foundations;Gene Amplification;Genetic;Glucose;Glutamates;Glutathione;Guidelines;Heterogeneity;human disease;improved;in vivo;Infection;insight;Interdisciplinary Study;Intermediate resistance;Intervention;Intravenous;Life;Malignant Neoplasms;Mediating;Medical;member;Metabolic;metabolomics;Modeling;Modern Medicine;mortality;Mus;Mutation;non-genetic;novel;novel strategies;novel therapeutics;Operative Surgical Procedures;Oral;pathogen;Pathway interactions;Patients;Pharmaceutical Preparations;Phenotype;Population;Predisposition;Prevalence;Prevalence Study;Process;Repression;Research Project Grants;Resistance;resistance mechanism;Risk;Role;Safety;Shunt Device;Signal Transduction;sugar;surveillance data;Testing;Time;Transplantation;Treatment Failure;Treatment outcome;Urinary tract infection;Work

PROJECT_TITLE: Heteroresistance Interdisciplinary Research Unit (Project 2)


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Digestive Diseases;Emerging Infectious Diseases;Genetics;Infectious Diseases;Nutrition

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: Project Narrative Diarrheal disease is a leading cause of childhood morbidity and mortality in the developing world. The goal of this work is to understand the nutritional signals that regulate the virulence of bacterial pathogens that cause diarrhea. Armed with this understanding, a simple dietary intervention may be devised to mitigate or prevent disease.

PI_NAMEs: WATNICK, PAULA I (contact)

PROGRAM_OFFICER_NAME: ZEITUNI, AMIR E

PROJECT_TERMS: Attenuated;Bacteria;Binding;Binding Proteins;Caring;Cell membrane;Cells;Childhood;ChIP-seq;Cholera;Chromosomes;Climate;Complex;Cues;Cyclic AMP Receptor Protein;Cytoplasm;Dehydration;design;Development;Diarrhea;diarrheal disease;Diet;Diet Modification;dietary;Dietary Intervention;Disease;Dissociation;Electrostatics;Environment;Enzymes;follow-up;Funding;Gene Activation;Gene Expression;genetic regulatory protein;Genetic Transcription;Glucose;Goals;Grant;Growth;gut colonization;In Vitro;in vivo;Incidence;Integral Membrane Protein;Internet;Intestines;Laboratories;Location;Lysine;Medical;Membrane;Membrane Lipids;Membrane Proteins;Metabolic;Metabolic Control;Metabolic Pathway;Metabolism;Microbial Biofilms;Modeling;Modification;Morbidity - disease rate;mortality;N-terminal;Nature;Nutrient;Nutrient availability;Nutritional;pandemic pathogen;pathogen;Pathogenesis;pathogenic bacteria;Pathogenicity;Post-Translational Protein Processing;prevent;Process;promoter;Protein translocation;Proteins;Regulation;Regulon;Research;Resource-limited setting;response;Role;Signal Transduction;Surface;transcription factor;Transcriptional Regulation;uptake;Vibrio cholerae;Virulence;Virulence Factors;virulence gene;Work

PROJECT_TITLE: Global regulators converge to orchestrate metabolism, biofilm, and pathogenesis

STUDY_SECTION: BACP

STUDY_SECTION_NAME: Bacterial Pathogenesis Study Section[BACP]


NIH_SPENDING_CATS: Clinical Research;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Infectious Diseases;Microbiome;Racial and Ethnic Minority Health Research;Sexually Transmitted Infections;Urologic Diseases;Women's Health Research

ORG_CITY: SAN FRANCISCO

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

ORG_STATE: CA

PHR: Project Narrative Chlamydia trachomatis is the most common bacterial cause of sexually transmitted infections (STI) in the world today that can lead to the severe sequelae including pelvic inflammatory disease, life-threatening ectopic pregnancy, and infertility. We lack a fundamental knowledge of the natural history of urogenital and rectal C. trachomatis infections that are likely interconnected and influenced by the respective microbiomes and host immune responses in each site. The objective of this research, therefore, is to elucidate the role of endocervical, vaginal and rectal microbiota and host immune responses in the acquisition and prevention of C. trachomatis among a high-incidence cohort of women to aid in designing strategies to decrease the growing global epidemic of C. trachomatis STIs and their devastating sequelae especially among neglected populations who have the highest rates of these infections.

PI_NAMEs: DEAN, DEBORAH ANNE (contact);READ, TIMOTHY D.

PROGRAM_OFFICER_NAME: VINCENT, LEAH REBECCA

PROJECT_TERMS: 16S ribosomal RNA sequencing;Age;age group;Anatomy;Area;Caring;Centers for Disease Control and Prevention (U.S.);Characteristics;chemokine;Chlamydia Infections;Chlamydia trachomatis;Clinical;Clinical Data;cohort;Communities;Country;cytokine;Data;design;Detection;Diagnostic;DNA;dysbiosis;Ectopic Pregnancy;Endocervix;Epidemic;Ethnic Origin;Female;Fiji;fitness;Future;Genetic;genetic variant;Genitourinary system;Genitourinary System Infection;Genome;Genomics;Guam;Hawaiian;health disparity;Hemorrhage;Heterosexuals;High Prevalence;host microbiota;human old age (65+);Immune;Immune response;improved;Incidence;Individual;ineffective therapies;Infection;infection rate;Infertility;Inflammation;Inflammatory Response;innovation;Intervention;Knowledge;Life;Lymphogranuloma Venereum;male;Medical;men who have sex with men;metagenome;metagenomic sequencing;Methods;microbiome;microbiota;Modeling;Natural History;neglect;Organism;Other Genetics;Outcome;Pacific Islander;Pacific Islands;Pacific Ocean;Papua New Guinea;pathogen;Pathogenicity;Pelvic Inflammatory Disease;Persons;Population;Premature Birth;Prevalence;Prevention;Proctitis;prospective;rectal microbiota;Rectum;Recurrence;Reporting;Research;Resource-limited setting;Risk;Role;Samoa;Sampling;screening;Severities;Severity of illness;Sexually Transmitted Diseases;Shotgun Sequencing;Signs and Symptoms;Site;Taxonomy;Teenagers;Time;transmission process;treatment duration;Treatment Protocols;urogenital tract;Vagina;vaginal microbiota;Woman;Women's cohort;Work;World Health Organization;young adult

PROJECT_TITLE: Natural History of C. trachomatis urogenital and rectal infections

STUDY_SECTION: IRAP

STUDY_SECTION_NAME: Infectious Diseases, Reproductive Health, Asthma and Pulmonary Conditions Study Section[IRAP]


ORG_NAME: EMORY UNIVERSITY

PI_NAMEs: LEVIN, BRUCE RICHARD (contact)

PROJECT_TERMS: Acinetobacter baumannii;analog;antibiotic design;Antibiotic Resistance;Antibiotic Therapy;Antibiotics;Area;Bacteria;Bacterial Antibiotic Resistance;bacterial resistance;Biochemical;Bioreactors;Cell Density;Cell Survival;Cells;Cessation of life;Clinical;clinical diagnostics;Clinical Treatment;Computer Simulation;cost;design;Detection;Devices;Diagnostic;diagnostic development;Diagnostic Procedure;Dose;Enterobacter;Enterobacteriaceae;Escherichia;Excision;Exhibits;experimental study;Exposure to;Fiber;fitness;Frequencies;Gene Amplification;Genetic;Goals;Growth;Heterogeneity;in vivo;Infection;Interdisciplinary Study;Intermediate resistance;Investigation;Klebsiella;mathematical model;Mathematics;Measurement;Mediating;Metabolic;metabolic abnormality assessment;Microfluidics;Minority Groups;Modeling;Molecular;Mutation;Nature;pathogen;Pharmaceutical Preparations;pharmacodynamic model;Pharmacodynamics;Pharmacotherapy;Phenotype;Physiological;Population;Population Dynamics;Predisposition;prevent;Process;Property;Protocols documentation;Regimen;Research;Research Project Grants;Resistance;Testing;Theoretical model;Time;Treatment Failure;Treatment Protocols

PROJECT_TITLE: Heteroresistance Interdisciplinary Research Unit (Project 3)


ADMINISTERING_IC: ES

FUNDING_MECHANISM: RESEARCH CENTERS

IC_NAME: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

PHR: PROJECT NARRATIVE The Center for Exposures, Diseases, Genomics, and Environment (EDGE) fosters novel research on molecular signatures associated with toxicant exposures using modern molecular and systems biology approaches to explain interactions between genetic, epigenetic and environmental factors and how these contribute to both acute and chronic diseases of public health importance. The EDGE Center is dedicated to contributing to evidence-based changes in regulatory policy and public health or medical practice that result in a reduction in the burden of environmentally related diseases.

PI_NAMEs: KAUFMAN, JOEL DANIEL (contact)

PROGRAM_OFFICER_NAME: THOMPSON, CLAUDIA L

PROJECT_TERMS: Acute Disease;Architecture;Assessment tool;Biochemical;Bioinformatics;Biological Markers;Biomedical Research;Biometry;built environment;Caliber;Cardiovascular Diseases;career;Cells;Chronic;Chronic Disease;Clinical;Clinical Sciences;Collaborations;Communication;Communities;community engagement;community partners;Complex;Core Facility;Creativeness;Data Analyses;Decision Making;Dedications;Development;developmental disease;direct application;Direct Costs;Disasters;Discipline;Disease;Education;Environment;Environmental Exposure;Environmental Health;Environmental Risk Factor;Epigenetic Process;epigenomics;evidence base;Evolution;Exposure to;Faculty;Fostering;Future;Gastrointestinal Diseases;gene environment interaction;Generations;Genetic;Genomics;Grant;Growth;Health Care Costs;health science research;Human;In Vitro;Infrastructure;innovation;Institution;instrumentation;Interdisciplinary Study;Intervention;Kidney Diseases;Leadership;Liver diseases;Malignant Neoplasms;Measures;Medical;member;Metabolic Diseases;metabolomics;Methodology;microbiome;microphysiology system;Mission;Modernization;Molecular;Molecular Biology;Molecular Profiling;Morbidity - disease rate;mortality;Multi-Ethnic Study of Atherosclerosis;National Institute of Environmental Health Sciences;Neurodegenerative Disorders;new technology;next generation;novel;novel strategies;Organ;outreach;Pathway interactions;Physiology;Pilot Projects;Policies;Population;Population Research;Population Study;premature;Prevention approach;Principal Investigator;Productivity;programs;Proteomics;Public Health;Publications;Pulmonary Heart Disease;Recording of previous events;Registries;reproductive system disorder;Research;Research Ethics;Research Personnel;Research Project Grants;Resources;Respiratory Disease;response;Role;Science;Scientist;social;success;System;Systems Biology;Technology;Tissues;Toxicant exposure;Toxicology;training opportunity;Translational Research;Twin Multiple Birth;United States National Institutes of Health;Universities;Vision;Washington

PROJECT_TITLE: University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment


NIH_SPENDING_CATS: Genetics;Human Genome

PROJECT_TERMS: Achievement;Advisory Committees;anti-cancer research;career;career development;cohesion;Collaborations;Communication;community engagement;Core Facility;Creativeness;Disease;Ensure;Environment;Evaluation;Fostering;Genomics;Infrastructure;innovation;Institution;meetings;member;Mentors;Mission;Molecular Profiling;Monitor;multidisciplinary;National Institute of Environmental Health Sciences;next generation;Outcome;outreach;Pediatric Hospitals;Pilot Projects;Program Evaluation;programs;Reporting;Research;Research Institute;Research Personnel;Resources;Schools;Science;Scientist;success;Suggestion;teacher;Translational Research;Universities;Washington;web site;Work

PROJECT_TITLE: Administrative Core


NIH_SPENDING_CATS: Clinical Research;Genetics;HIV/AIDS;Infectious Diseases;Prevention;Women's Health Research

ORG_CITY: Durban

ORG_NAME: CENTRE/AIDS PROGRAMME/RES/SOUTH AFRICA

PHR: PROJECT NARRATIVE In this proposal we aim to define the mechanisms of IFN2 induction and its impact on interferon signaling and target cell phenotypes at the site of HIV transmission using longitudinal mucosal sampling from the ongoing clinical trial. In addition to providing crucial information on IFN signaling in HIV infection, the results of this study will provide key information on the role of pre-existing inflammation and the role of timing and duration of exogenous IFN stimulation on generation of potent antiviral immune responses in prevention and treatment of viral infections.

PI_NAMEs: SIVRO, AIDA  (contact)

PROGRAM_OFFICER_NAME: MCDONALD, DAVID JOSEPH

PROJECT_TERMS: 2019-nCoV;Address;Anti-viral Response;Biometry;Cells;Chronic;Clinical Research;Clinical Trials;Cohort Analysis;Cohort Studies;COVID-19;cytokine;desensitization;design;Down-Regulation;Enrollment;Epidemiology;female reproductive tract;Gel;Gene Expression;gene repression;Generations;Genetic Transcription;Genitalia;High Risk Woman;HIV;HIV Infections;HIV risk;Immune;Immune response;Immunology;immunopathology;Impairment;Implant;In Vitro;in vitro Model;in vivo;Infection;Inflammation;Inflammatory;Interferon Type I;Interferons;International;Link;Location;Macaca mulatta;Measures;Mediating;Modeling;Mucous Membrane;multidisciplinary;nonhuman primate;pandemic disease;Pathogenicity;Pathway interactions;Peripheral Blood Mononuclear Cell;permissiveness;Phenotype;Predisposition;prevent;Prevention;programs;prophylactic;Prospective cohort;Research Personnel;response;Risk;Role;Sampling;Signal Transduction;single-cell RNA sequencing;Site;South Africa;subcutaneous;Surface;Systemic infection;Tenofovir;Testing;Therapeutic;transcriptomics;transmission process;Up-Regulation;Viral;Viral Genes;Virus;Virus Diseases;Woman;young woman

PROJECT_TITLE: Mechanisms of type I IFN signaling and HIV risk in the female genital tract

STUDY_SECTION: HIVD

STUDY_SECTION_NAME: HIV Immunopathogenesis and Vaccine Development Study Section[HIVD]


ORG_NAME: SEATTLE CHILDREN'S HOSPITAL

PHR: Project Narrative  The goal of our laboratory is to understand the mechanisms of action of volatile anesthetics (VAs) in order to optimize clinical care and understand control of consciousness. We discovered that VAs inhibit mitochondrial function, producing specific defects in excitatory neurotransmission. We are extending the studies of VAs and mitochondria to understand arousal from the anesthetic state, and how VAs produce undesired long-term effects.

PI_NAMEs: MORGAN, PHILIP G (contact)

PROGRAM_OFFICER_NAME: JUSTINOVA, ZUZANA

PROJECT_TERMS: Affect;Anesthesia procedures;Anesthetics;Animals;Arousal;Astrocytes;Behavior;Caenorhabditis elegans;Cells;cholinergic neuron;clinical care;Complex;Conscious;Data;Defect;Electron Transport;Endocytosis;Endoplasmic Reticulum;endoplasmic reticulum stress;FRAP1 gene;genetic approach;Glutamates;Goals;Hand;Human;Isoflurane;Laboratories;Link;locus ceruleus structure;Long-Term Effects;man;Mediating;Metabolic;Metabolism;Mitochondria;Modern Medicine;Molecular Mechanisms of Action;mTOR inhibition;Mus;Nematoda;neonatal mice;Neural Pathways;Neurons;neurotoxicity;neurotransmission;Neurotransmitters;novel;novel strategies;Pathway interactions;Phylogenetic Analysis;Production;Proteins;response;Role;Signal Pathway;Signal Transduction;small molecule;Synapses;synaptic function;synaptic inhibition;Testing;Unconscious State;Volatilization;Work

PROJECT_TITLE: Volatile Anesthetics and Metabolism

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-CB-J(55)R]


NIH_SPENDING_CATS: Genetics;Human Genome;Prevention;Social Determinants of Health

PI_NAMEs: KARR, CATHERINE J (contact)

PROJECT_TERMS: Address;Area;Basic Science;Biomedical Research;catalyst;Child;Clinical;Clinical Research;Clinical Sciences;Collaborations;Collection;Communities;community center;community engaged research;community engagement;community partners;Consultations;Core Facility;data to knowledge;Dedications;Disasters;Discipline;Disease;Early Diagnosis;Environment;Environmental Health;Environmental Risk Factor;Epigenetic Process;Ethics;Evolution;exposed human population;Fostering;Fred Hutchinson Cancer Research Center;Funding;Funding Opportunities;gene environment interaction;Genetic;Genomics;Goals;Health;Health Policy;health practice;health science research;Health Sciences;Human;implementation science;improved;Individual;innovation;instrumentation;Interdisciplinary Study;Leadership;member;Methods;National Institute of Environmental Health Sciences;novel;Occupational Health;organizational structure;Patients;Physiological;population based;population health;Population Study;Predisposition;Prevention;programs;Public Health;Public Health Schools;repository;Research;Research Design;Research Institute;Research Personnel;Resources;response;Sampling;Science;Scientist;Services;Technology;Testing;Translational Research;Universities;virtual;Washington

PROJECT_TITLE: Integrative Environmental Health Sciences Facility Core


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Dementia;Genetics;Human Genome;Infectious Diseases;Neurodegenerative;Neurosciences

ORG_CITY: NEW YORK

ORG_NAME: WEILL MEDICAL COLL OF CORNELL UNIV

PHR: Project Narrative This study proposes to use comprehensive profiling of the patients' own immune cells to guide how to manage the complex presentation of brain impairments seen between older HIV individuals from those afflicted with early stages of Alzheimer's disease.

PI_NAMEs: NDHLOVU, LISHOMWA C (contact);VALCOUR, VICTOR

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Acute;Address;Adult;Age;Age Years;aging population;Alzheimer's Disease;American;antiretroviral therapy;base;Biological;Blood;brain dysfunction;Cell Physiology;cell type;Cells;Central Nervous System Degenerative Diseases;Clinical;Cognition;Cognitive;cognitive performance;cohort;Complex;Data;Detection;Diagnostic;DISC1 gene;Disease;disease classification;DNA Methylation;DNA methylation profiling;Early Diagnosis;Environmental Risk Factor;Epigenetic Process;epigenetic profiling;epigenome;Event;experience;gene editing technology;Genes;Genetic;Genome;geriatric neuroHIV;histone modification;HIV;HIV Infections;HIV-associated cognitive impairment;HIV-associated neurocognitive disorder;Immune;immune activation;Immunologic Markers;Immunologics;Impaired cognition;improved;Individual;Inflammation;Inflammatory Response Pathway;innovation;Intervention;Knowledge;Link;Macrophage;Mediator;Methods;Methylation;methylome;Microglia;mild cognitive impairment;Molecular;monocyte;multidisciplinary;multiple omics;Myeloid Cells;Nerve Degeneration;neuroinflammation;Neuropsychological Tests;new technology;novel;NR4A2 gene;older adult;Outcome;Pathogenesis;Pathway interactions;Patients;Persons;Phenotype;Population;Positioning Attribute;Predisposition;Process;Property;Publishing;Rare Diseases;recruit;Resolution;Role;single cell analysis;single cell technology;single-cell RNA sequencing;Site;Sorting;Specimen;structural imaging;Technology;Testing;THBS1 gene;treatment strategy;Viremia;Work

PROJECT_TITLE: Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction


ADMINISTERING_IC: DA

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Behavioral and Social Science;Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Drug Abuse (NIDA only);Neurosciences;Opioid Misuse and Addiction;Opioids;Pain Research;Patient Safety;Prescription Drug Misuse;Substance Misuse

ORG_CITY: NASHVILLE

ORG_NAME: VANDERBILT UNIVERSITY MEDICAL CENTER

ORG_STATE: TN

PHR: NARRATIVE Post-surgical opioids contribute substantially to the burden of opioid misuse, opioid use disorder, and overdose, which caused nearly 70,000 U.S. deaths in 2020. The partial opioid agonist buprenorphine represents a potential alternative; this study will evaluate its abuse potential and determine its feasibility and acceptability for postoperative analgesia. Results may lead to new practices for treating postoperative pain that confer lower risk of opioid-related harms.

PI_NAMEs: LARACH, DANIEL  (contact)

PROGRAM_OFFICER_NAME: LAO, GUIFANG

PROJECT_TERMS: Absence of pain sensation;abuse liability;acceptability and feasibility;Acute Pain;Address;Adverse effects;American;Analgesics;antagonist;authority;Biometry;Buprenorphine;career;career development;Caring;Cessation of life;Chad;chronic pain;Clinical;clinical database;Clinical Investigator;clinical pain;Clinical Sciences;Clinical Trials Design;Crossover Design;Data;design;Development;Development Plans;Diagnosis;disorder risk;Dose;Drug abuse;Drug Prescriptions;Enrollment;Euphoria;experience;Exposure to;FDA approved;feasibility testing;follow-up;Formulation;Friends;Funding;Iatrogenesis;indexing;insight;Intravenous;Journals;Knowledge;Learning;Light;Mentors;mu opioid receptors;Observational Study;Operative Surgical Procedures;Opioid;opioid abuse;Opioid agonist;opioid misuse;opioid mortality;opioid overdose;opioid use;opioid use disorder;Oral;Overdose;overdose risk;Oxycodone;Pain;Pain management;Participant;participant enrollment;Patients;Pattern;Pharmaceutical Preparations;Pharmacodynamics;Phenotype;Physicians;Placebos;Positioning Attribute;Positive Reinforcements;Postoperative Pain;Postoperative Period;prescription opioid;prescription opioid misuse;Psychophysics;psychosocial;Psychosocial Factor;Publications;Randomized;randomized, clinical trials;Randomized, Controlled Trials;Reporting;Research Training;response;Risk;risk/benefit ratio;Seminal;Sensory;Shapes;skills;Specialist;Standardization;Testing;Training;Translational Research;translational scientist;translational study;United States National Institutes of Health;Ventilatory Depression;Veterans;Work

PROJECT_TITLE: Low-dose buccal buprenorphine: Relative abuse potential and postoperative analgesic acceptability

STUDY_SECTION: IPTA

STUDY_SECTION_NAME: Interventions to Prevent and Treat Addictions Study Section[IPTA]


NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Genetics;Infectious Diseases

ORG_CITY: TAMPA

ORG_NAME: UNIVERSITY OF SOUTH FLORIDA

ORG_STATE: FL

PHR: Staphylococcus aureus is a highly virulent and widely successful pathogen that is speculated to be the most common cause of human infection. With the continued emergence of multi-drug resistant isolates of S. aureus (such as MRSA), there is an urgent need to understand the mechanisms by which this deadly pathogen causes disease. This proposal seeks to explore the contribution of a membrane associated, C-terminal processing protease to S. aureus virulence.

PI_NAMEs: SHAW, LINDSEY NEIL (contact)

PROGRAM_OFFICER_NAME: HUNTLEY, CLAYTON C

PROJECT_TERMS: Bacillus subtilis;Binding;Blood;Brain;C-terminal;Cell Cycle;Cell division;Cell Physiology;Cells;cellular targeting;Collaborations;Corynebacterium glutamicum;Cytoplasm;Disease;DNA Damage;Enterococcus faecalis;Enzymes;Event;Exposure to;Family;Genetic Transcription;Growth;Heart;Heat Stress;Human;Immune;Immune system;Infection;inhibitor;insight;Kidney;Light;Link;Macrophage;Mediating;Membrane;methicillin resistant Staphylococcus aureus;mouse model;Multi-Drug Resistance;Mus;mutant;Mutation;Mycobacterium tuberculosis;N-terminal;novel;Organ;Organism;pathogen;Pathogenesis;Peptide Hydrolases;Production;protein degradation;Proteins;Publishing;repaired;Repression;Role;Sepsis;Serine;Serum;Signal Transduction;SOS Response;Specificity;Spleen;Staphylococcus aureus;Stress;Structure;Techniques;Time;Virulence;Virulent;Visualization;Work

PROJECT_TITLE: Dissecting the Influence of a C-Terminal Processing Protease on S. aureus Pathogenesis

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-IDM-R(02)M]


ORG_CITY: College Station

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: TEXAS A&M AGRILIFE RESEARCH

PHR: Protein Kinase C (PKC) enzymes have been implicated in many human pathologies. We will uncover the molecular mechanisms that regulate the enzymatic activity of PKC. The results of the proposed studies will facilitate the development of novel ways to prevent the progression of cancer, Alzheimer's disease, and cardiac disease.

PI_NAMEs: IGUMENOVA, TATYANA I. (contact)

PROGRAM_OFFICER_NAME: LEWIS, MECHELLE MAYLEBEN

PROJECT_TERMS: Address;Affinity;Alzheimer's Disease;Basic Science;Binding;Binding Sites;Biochemical;biophysical techniques;Biophysics;Chemicals;Complex;Coupled;Data;design;Detection;Development;Diabetes Mellitus;Diglycerides;Ensure;Enzymes;Eukaryotic Cell;Event;Exhibits;experimental study;Family;Funding;Health;Heart Diseases;HIV/AIDS;Human;Human Pathology;Hydrophobicity;In Vitro;insight;Isoenzymes;Knowledge;Ligands;Lipids;Malignant Neoplasms;Membrane;Membrane Lipids;Membrane Proteins;Molecular;Molecular Conformation;molecular dynamics;Mutation;novel;Outcome;pharmacologic;Pharmacologic Substance;Phenotype;phosphatidylinositol phosphate, PtdIns(4,5)P2;Phosphatidylinositols;Phospholipids;Phosphotransferases;Play;prevent;Process;protein activation;Protein Kinase C;Protein Kinase C Inhibitor;protein kinase modulator;Proteins;recruit;Regulation;Research Proposals;Resolution;response;Role;Signal Pathway;Signal Transduction;Signaling Protein;simulation;Structural Models;Structure;System;Tertiary Protein Structure;Testing;Therapeutic Research;tumor progression;Tumor Promoters;Tumor Suppressor Proteins;two-dimensional

PROJECT_TITLE: Structural and functional studies of protein kinase C regulation

STUDY_SECTION: BBM

STUDY_SECTION_NAME: Biochemistry and Biophysics of Membranes Study Section[BBM]


PI_NAMEs: CUI, JULIA YUE  (contact)

PROJECT_TERMS: 3-Dimensional;Address;Animal Model;Applications Grants;Architecture;Area;Bioinformatics;Biological;Biological Models;biological systems;Biometry;Canis familiaris;Chemical Exposure;Chemicals;Complement;Complex;complex data;Consultations;Core Facility;cost effective;Data;Data Analyses;design;Disease;Disease Marker;Disease susceptibility;Early identification;Emerging Technologies;empowerment;Environment;environmental agent;Environmental Health;Environmental Risk Factor;epidemiology study;Epigenetic Process;epigenomics;Exposure to;functional genomics;Funding;Generations;Genetic;Genetic Polymorphism;Genome;Genomics;Goals;health science research;Human;improved;In Vitro;in vitro Model;Incidence;Individual;Infrastructure;insight;Investigation;Mammalian Cell;Manuscripts;Measurement;metabolomics;metabolomics resource;Methodology;Methods;microphysiology system;Molecular;Molecular Epidemiology;Molecular Target;Monitor;new technology;novel;Organ;Pathway interactions;personalized intervention;Physiological;Physiology;Policy Making;Precision therapeutics;Preparation;programs;Proteins;Proteomics;Public Health;Research;Research Personnel;Resources;response;RNA;Rodent;Sampling;Services;single cell sequencing;System;Technology;Testing;Tissues;Toxic effect;toxicant;Toxicology;transcriptomics;Universities;Washington;Xenobiotics

PROJECT_TITLE: Genomics, Bioinformatics & Biostatistics, and Microphysiological Systems Core