NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biomedical Imaging;Brain Disorders;Clinical Research;Dementia;Neurodegenerative;Neurosciences;Nutrition;Obesity;Prevention

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: Project Narrative: The purpose of this project is to enhance our knowledge on the relationship between metabolically abnormal versus normal overweight or obesity with normal cognition and i) neurodegeneration as reflected by brain atrophy on MR imaging ii) neuroinflammation quantified by a new type of diffusion MR imaging called diffusion basis spectrum imaging and iii) AD pathology characterized by amyloid and tau PET imaging. The proposal will generate a new midlife cohort with classifications of metabolically abnormal overweight or obesity with amyloid, tau, neuroinflammation and neurodegeneration imaging markers. Investigating this relationship will establish key understanding of how obesity can increase risk for Alzheimer’s disease and consequently inform future prevention strategies.

PI_NAMEs: RAJI, CYRUS A (contact)

PROGRAM_OFFICER_NAME: GHALEH, MARYAM X

PROJECT_TERMS: Abdomen;Adipose tissue;Affect;Age;Aging;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Amyloid;Amyloid beta-Protein;amyloid imaging;Amyloidosis;Anatomy;Atrophic;Attenuated;Biological Markers;Body fat;Body mass index;Brain;brain dysfunction;brain health;Brain imaging;brain magnetic resonance imaging;Brain region;brain volume;Categories;cerebral atrophy;cingulate gyrus;Classification;Cognition;Cognitive;cohort;Collaborations;cost;Cross-Sectional Studies;Dementia;dementia risk;Deposition;Diffusion;Drug or chemical Tissue Distribution;Fasting;fasting plasma glucose;Fatty acid glycerol esters;Funding;Future;Glucose;Glycosylated hemoglobin A;high risk;Hippocampus;Human;Hypertension;Image;imaging biomarker;Impairment;Individual;Inflammation;insight;Insulin;Insulin Resistance;insulin sensitivity;interest;Intervention Studies;Knowledge;Learning;Link;Liver;Magnetic Resonance Imaging;Measurement;Memory;men;Metabolic;Metabolism;Methods;middle age;mouse model;MRI Scans;Nerve Degeneration;neuroimaging;neuroimaging marker;neuroinflammation;Non-Insulin-Dependent Diabetes Mellitus;nutrition;Obese Mice;obese person;Obesity;obesity risk;OGTT;Overweight;Participant;Patient Recruitments;Persons;Plasma;Positron-Emission Tomography;Prevention strategy;Process;Public Health;Radiology Specialty;recruit;Research;Risk;Risk Reduction;Sex Differences;spectrograph;subcutaneous;Sum;systemic inflammatory response;tau Proteins;Testing;Thinness;Time;Tissues;trend;United States;Universities;Visceral;Visceral fat;Washington;white matter;Woman;women versus men

PROJECT_TITLE: Neuroinflammation and Alzheimer's Disease Imaging Biomarkers in Midlife Obesity

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-BDCN-L(02)]


ADMINISTERING_IC: AG

ARRA_FUNDED: N

ED_INST_TYPE: SCHOOLS OF MEDICINE

FUNDING_MECHANISM: NON-SBIR/STTR RPGS

IC_NAME: NATIONAL INSTITUTE ON AGING

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Biotechnology;Brain Disorders;Dementia;Genetics;Lewy Body Dementia;Neurodegenerative;Neurosciences;Parkinson's Disease;Stem Cell Research;Stem Cell Research - Induced Pluripotent Stem Cell;Stem Cell Research - Induced Pluripotent Stem Cell - Human

ORG_CITY: LA JOLLA

ORG_COUNTRY: UNITED STATES

ORG_DEPT: NEUROSCIENCES

ORG_FIPS: US

ORG_NAME: UNIVERSITY OF CALIFORNIA, SAN DIEGO

ORG_STATE: CA

PHR: PROJECT NARRATIVE Alzheimer’s disease related disorders (ADRDs) are involved not only the accumulation of amyloid ß and tau but also alpha-synuclein (α-syn). We recently developed a novel peptide for delivery short oligonucleotides across the blood-brain barrier to reduce the expression of proteins such as α-syn. In this proposal we will utilize our expertise in delivering an siRNA against α-syn to the brain to examine the pharmacokinetics and pharmacodynamics of reducing α-syn to determine in models of Dementia with Lewy bodies if this is a viable therapeutic option to move forward for clinical trials.

PI_NAMEs: RISSMAN, ROBERT  (contact)

PROGRAM_OFFICER_NAME: GROTHAUS, PAUL G

PROJECT_TERMS: abeta accumulation;Address;Affect;Affinity;Age Months;aging population;alpha synuclein;Alpha-Synuclein transgenic mouse;Alzheimer's Disease;Alzheimer's disease related dementia;Amino Acids;Amyloid beta-Protein;Antisense Oligonucleotides;Apolipoproteins B;Astrocytes;Autopsy;behavior test;Behavioral;Binding;Blood - brain barrier anatomy;blood-brain barrier penetration;Brain;Cells;clinical efficacy;Clinical Trials;cognitive ability;cognitive testing;Collaborations;Consultations;Data;Dementia;Dementia with Lewy Bodies;design;Disease;Dose;Drug Kinetics;efficacy testing;Endothelium;experimental study;FYN gene;Half-Life;Human;human model;Impaired cognition;improved;in vitro Model;Induced pluripotent stem cell derived human neuron;Induced pluripotent stem cell derived neurons;Injections;intraperitoneal;Intrathecal Injections;Kinetics;knock-down;Learning;Lewy Bodies;Lewy neurites;Measures;Mediating;Memory;Messenger RNA;Metabolic Clearance Rate;Methodology;Methods;Microtubule-Associated Proteins;Modeling;Motor;Motor Activity;motor symptom;mouse model;Multiple System Atrophy;Mus;Nerve Degeneration;Nervous System Disorder;Neurobehavioral Manifestations;Neurodegenerative Disorders;neuroinflammation;neuronal survival;Neurons;neuropathology;novel;novel strategies;Oligonucleotides;Parkinson Disease;Parkinsonian Disorders;Pathologic;Pathology;Patients;Peptide Transport;Peptides;Peripheral;pharmacokinetics and pharmacodynamics;Plasma;prevent;protein aggregation;protein expression;Proteins;Recovery;Regulation;Ribonucleotides;RNA;Role;Safety;siRNA delivery;Small Interfering RNA;Synapses;Therapeutic;Tissues;Toxicology;Translations;Treatment Efficacy;uptake;Vertebral column;Work

PROJECT_TITLE: Novel Systemic Delivery of Peptide-Mediated Anti-Sense Oligonucleotides for Dementia with Lewy Bodies

STUDY_SECTION: DDNS

STUDY_SECTION_NAME: Drug Discovery for the Nervous System Study Section[DDNS]


ADMINISTERING_IC: OH

ED_INST_TYPE: SCHOOLS OF PUBLIC HEALTH

FUNDING_MECHANISM: OTHERS

IC_NAME: NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH

ORG_CITY: TUCSON

ORG_DEPT: PUBLIC HEALTH & PREV MEDICINE

ORG_NAME: UNIVERSITY OF ARIZONA

ORG_STATE: AZ

PHR: Narrative Occupational injury and illness affect millions of workers and their families every year and are tremendous economic burdens on our society. Highly qualified, technically competent, and passionate industrial hygienists are needed to meet our national goal to prevent occupational illness, injury, and fatalities, as described in the DHHS Healthy People 2020.

PI_NAMEs: BURGESS, JEFFEREY L. (contact)

PROJECT_TITLE: Graduate Industrial Hygiene Training Program Grant, University of Arizona


ADMINISTERING_IC: GH

IC_NAME: Center for Global Health

ORG_CITY: HOUSTON

ORG_DEPT: PEDIATRICS

ORG_NAME: BAYLOR COLLEGE OF MEDICINE

ORG_STATE: TX

PHR: PROJECT NARRATIVE Our research project is designed to improve the health and survival of children, adolescent, and adults living with HIV who suffer most from the world’s leading infectious causes of death: tuberculosis (TB) and HIV. Our team is uniquely positioned to develop, implement, and evaluate evidence-based, innovative approaches to prevent, find, and cure HIV-associated TB in five CDC target priority countries. Our research will develop innovative new strategies to improve our ability to FIND and PREVENT TB, while determining the most cost- effective prevention strategy and promoting best practices to SUSTAIN the impact of our work.

PI_NAMEs: MANDALAKAS, ANNA M (contact)

PROJECT_TITLE: Closing -TB GAPs - for people living with HIV: TB Guidance for Adaptable Patient-Centered Service


ADMINISTERING_IC: DK

IC_NAME: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Diabetes;Heart Disease;Neurodegenerative;Nutrition;Obesity;Physical Activity;Prevention;Vascular Contributions to Cognitive Impairment and Dementia (VCID);Women's Health Research

ORG_CITY: BALTIMORE

ORG_DEPT: INTERNAL MEDICINE/MEDICINE

ORG_NAME: JOHNS HOPKINS UNIVERSITY

ORG_STATE: MD

PHR: Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. We propose to use The Look AHEAD (Action for Health In Diabetes) Study to examine the association between endogenous sex hormones (testosterone, estradiol and sex hormone binding globulin) and cardiovascular disease risk factors, over 8 years, by sex, and in response to the intensive lifestyle intervention among 3000 study participants with type 2 diabetes.

PI_NAMEs: BENNETT, WENDY LYNET (contact);VAIDYA, DHANANJAY MADHUKAR

PROGRAM_OFFICER_NAME: LAWRENCE, JEAN M

PROJECT_TERMS: Address;adjudication;adverse outcome;Age;Albumins;Biological;Blood Pressure;Body Composition;Body mass index;Body Weight decreased;cardiometabolic risk;cardiometabolism;Cardiovascular Diseases;cardiovascular disorder prevention;cardiovascular disorder risk;Chronic Disease;Chronic Kidney Failure;Clinical;clinically significant;comparison intervention;Control Groups;Coronary heart disease;Data;design;diabetes management;Diabetes Mellitus;Diet;disadvantaged women;Disparity;Eating;Education;Estradiol;Etiology;Event;Exercise;Female;follow-up;General Population;Glycosylated hemoglobin A;Gonadal Steroid Hormones;Health;healthy lifestyle;Hormonal Change;improved;Individual;kidney vascular structure;Life Style;Life Style Modification;lifestyle intervention;Lipids;Longitudinal Studies;Measurement;men;Morbidity - disease rate;mortality;Myocardial Infarction;Non-Insulin-Dependent Diabetes Mellitus;Obesity;Outcome;Overweight;Participant;Persons;Physical activity;Prevalence;Preventive measure;Preventive treatment;primary outcome;Randomized, Controlled Trials;Recommendation;Relative Risks;Research;response;Risk;Risk Factors;Role;sex;sex as a biological variable;Sex Differences;Sex Hormone-Binding Globulin;Stroke;Testing;Testosterone;Time;treatment arm;United States National Institutes of Health;Vascular Dementia;waist circumference;Weight;Woman;women versus men

PROJECT_TITLE: The Effect of Sex Hormones on Cardiometabolic Outcomes in Men and Women with Diabetes: The Look AHEAD (Action for Health in Diabetes) Study

STUDY_SECTION: CIDO

STUDY_SECTION_NAME: Clinical and Integrative Diabetes and Obesity Study Section[CIDO]


ADMINISTERING_IC: TR

IC_NAME: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

NIH_SPENDING_CATS: Biotechnology;Clinical Research;Data Science;Genetics;Human Genome;Networking and Information Technology R&D (NITRD);Pediatric

ORG_CITY: BOSTON

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

ORG_STATE: MA

PHR: Project Narrative We capacitate a CTSA-wide, federated, Genomics Information Commons (GIC), underpinned by coordinated, local, broadly consented biobanking initiatives. The goal is rapid identification and analysis of representative cohorts, made possible by a federated IT infrastructure, with advanced phenotype and genotype query capability, available to all participating CTSA investigators. The GIC is self-scaling, so that CTSCs can modularly join, contribute, and benefit.

PI_NAMEs: MANDL, KENNETH D. (contact)

PROGRAM_OFFICER_NAME: GANNOT, GALLYA

PROJECT_TERMS: Address;African ancestry;Age;application programming interface;Authorization documentation;Big Data to Knowledge;biobank;Biological;black patient;Caring;Childhood;Clinical;cohort;Collaborations;comorbidity;Complex;Confidence Intervals;Consent;Creativeness;Data;Data Aggregation;data modeling;Data Science;Data Set;data sharing;Data Sources;Databases;Diagnosis;Diagnostic;Disease;Electronic Health Record;Enrollment;Environment;ethnic diversity;exome;Fast Healthcare Interoperability Resources;Fostering;Frequencies;Gender;Genes;Genetic;Genetic Databases;genetic pedigree;genetic variant;Genome;genomic data;Genomics;Genotype;Goals;Heterogeneity;Hospitals;Hypertrophic Cardiomyopathy;improved;Individual;Industry Collaboration;Informatics;Information Resources;Information Systems;Infrastructure;innovation;Institution;Institutional Review Boards;instrument;Journals;Laboratories;Licensing;Link;Medicine;National Health and Nutrition Examination Survey;Nature;New England;open source;Outcome;Pathogenicity;patient population;Patients;Pediatric Hospitals;Phenotype;phenotypic data;Policies;Population;population based;Population Heterogeneity;Process;Prognosis;programs;Protocols documentation;Publishing;Recontacts;Reference Values;Reporting;Research;Research Personnel;Resources;Sampling;Secure;self organization;Site;System;Technology;Testing;Time;tool;treatment response;United States National Institutes of Health;Update;Variant;Vertebral column;whole genome;Work

PROJECT_TITLE: Instrumenting the Delivery System for a Genomics Research Information Commons


ADMINISTERING_IC: VA

IC_NAME: Veterans Affairs

ORG_CITY: White River Junction

ORG_NAME: WHITE RIVER JUNCTION VA MEDICAL CENTER

ORG_STATE: VT

PHR: The fungal pathogen Candida albicans is a leading cause of hospital-associated bloodstream infections, and is directly responsible for increased mortality, length of stay, and healthcare costs in our veteran patient population. Current antifungal therapy remains suboptimal, and there are only three major classes of antifungal drugs available. Furthermore, resistance to current antifungal therapies is developing, and biofilm-related infections are particularly resistant to standard antifungal drugs. Secretion of proteins is an important mediator of filamentation, biofilm formation, and virulence in C. albicans. In this project, we will investigate the role of the endocytic component of secretion, focusing on genes involved in several key sequential steps in this process, and define their roles in filamentation, biofilm formation, and virulence. This project expands upon our long- standing studies of secretion in C. albicans, but focuses on pathways that we have not previously studied and are likely of great importance to understand how C. albicans causes infection.

PI_NAMEs: LEE, SAMUEL AUSTIN;SHINER, BRIAN  (contact)

PROJECT_TERMS: anti-fungal agents;anti-microbial drug;Antifungal Therapy;Aspartic Endopeptidases;Attenuated;Biochemical;biological adaptation to stress;Biology;Caenorhabditis elegans;Candida;Candida albicans;Candidiasis;Caring;Catheters;Cell membrane;Cellular biology;clinically significant;Collection;comparative genomics;Complex;Critical Pathways;Data;Death Rate;Defect;Diagnosis;Disease;Disseminated candidiasis;Endocytosis;Endocytosis Pathway;Enzymes;Exocytosis;extracellular;Filament;forward genetics;Fungemia;fungus;Future;Genes;Genetic;genetic approach;genetic regulatory protein;Genomic approach;Growth;Health Care Costs;Homologous Gene;Hospitals;Human;Immune;improved;In Vitro;in vitro Model;in vivo;in vivo Model;Infection;Intake;Intervention;Intravenous;Invaded;Investigation;Length of Stay;Libraries;Link;Lipase;lucifer yellow;Macrophage;Mediating;Mediator;Medical;Membrane Proteins;Methods;Microbial Biofilms;Modeling;Molecular;Molecular Biology;Morphogenesis;mortality;Mucous Membrane;Mus;mutant;Mutation;new therapeutic target;novel;Pathogenesis;pathogenic fungus;Pathway interactions;patient population;Phenotype;Play;prevent;Process;protein complex;Protein Secretion;Proteins;Recycling;Resistance;Role;Route;Saccharomyces;Saccharomyces cerevisiae;screening;Secretory Component;Sepsis;Skin;SNAP receptor;Structure;Tail;Tissues;trafficking;Urinary tract infection;Veins;Veterans;Virulence;Work

PROJECT_TITLE: Endocytosis in Candida filamentation, biofilm formation and virulence

STUDY_SECTION: INFB

STUDY_SECTION_NAME: Infectious Diseases B[INFB]


ADMINISTERING_IC: EB

ED_INST_TYPE: SCHOOLS OF VETERINARY MEDICINE

FUNDING_MECHANISM: OTHER RESEARCH-RELATED

IC_NAME: NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

NIH_SPENDING_CATS: Bioengineering

ORG_CITY: ATHENS

ORG_DEPT: VETERINARY SCIENCES

ORG_NAME: UNIVERSITY OF GEORGIA

ORG_STATE: GA

PHR: PROJECT NARRATIVE The proposed training initiative is highly relevant to public health as it defines a program to cultivate a diverse pool of research leaders who will be able to collaboratively and thoughtfully address a diverse set of public health issues and challenges. The research itself covers a wide range of bioengineering technologies; the scholars will learn the relationship between fundamental and applied research and how to efficiently translate ideas to public good. Most importantly, they will learn to listen and ask open-ended questions that better inform their research and translation of research to clinical practice.

PI_NAMEs: BIRKES, ANGELA Y;BURG, KAREN JL (contact);GOMILLION, CHERYL T

PROGRAM_OFFICER_NAME: GATLIN, TINA L

PROJECT_TERMS: Acceleration;Address;Animals;Applied Research;Area;Bachelor's Degree;Belief;Biomedical Engineering;Biomedical Research;Businesses;career;Cementation;clinical practice;college;Communities;community engagement;Degree Completion;design;Discipline;Doctor of Medicine;Doctor of Philosophy;driving force;Educational Curriculum;Educational workshop;Elements;Employment;Engineering;Enrollment;Ensure;Environment;Evaluation;experience;fundamental research;Goals;graduate school;Grant;Growth;Health;Human;Industrialization;innovation;Institution;interest;Knowledge;Lead;Learning;lens;living-learning community;Medicine;meetings;Mentors;Minority Groups;Monitor;Nature;Occupations;outreach;peer coaching;Personal Communication;Physiological;Postbaccalaureate;Postdoctoral Fellow;preservation;Process Assessment;programs;Public Health;Publications;Research;Research Infrastructure;Research Project Grants;Research Training;responsible research conduct;Science;Science, Technology, Engineering and Mathematics;skills;STEM career;STEM field;STEM research;success;summer research;symposium;technological innovation;Technology;Training;Translating;Translational Research;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;underserved community;United States;Universities;Vanadium;Vocabulary;Work

PROJECT_TITLE: University of Georgia (UGA) ESTEEMED: Mentored Experiential Research to Promote Diversity in Biomedical Engineering and Science


ADMINISTERING_IC: DA

ED_INST_TYPE: SCHOOLS OF ARTS AND SCIENCES

IC_NAME: NATIONAL INSTITUTE ON DRUG ABUSE

NIH_SPENDING_CATS: Bioengineering;Biotechnology;Brain Disorders;Drug Abuse (NIDA only);HIV/AIDS;Infectious Diseases;Nanotechnology;Neurodegenerative;Neurosciences;Opioid Misuse and Addiction;Opioids;Substance Misuse

ORG_CITY: UNIVERSITY

ORG_DEPT: CHEMISTRY

ORG_NAME: UNIVERSITY OF MISSISSIPPI

ORG_STATE: MS

PHR: PROJECT NARRATIVE Current antiretroviral therapies cannot target HIV reservoirs in the central nervous system and opioids further increase the efflux of drugs from the central compartment. We have developed an ionic liquid-based drug delivery system that vastly increases the amount of drug that can be delivered to the brain and targets microglia with high selectivity. This proposal will generate new ionic liquid formulations with tunable affinity for different cell types and will establish their safety and efficacy in complementary in vitro and in vivo models.

PI_NAMEs: PARIS, JASON RICHARD;TANNER, EDEN  (contact)

PROGRAM_OFFICER_NAME: BORGMANN, KATHLEEN RUTH

PROJECT_TERMS: abacavir;ABCB1 gene;Acute;Affinity;Ames Assay;Anions;Anti-Retroviral Agents;antiretroviral therapy;Astrocytes;astrogliosis;Attenuated;Biochemical;Biocompatible Materials;Biodistribution;Biological;Biological Assay;biomaterial compatibility;Blood;Blood - brain barrier anatomy;Brain;Brain region;Cations;Cell Adhesion;cell type;Cells;Central Nervous System;Central Nervous System Agents;Chemistry;clinical development;Collaborations;Complete Blood Count;Complication;CRISPR/Cas technology;cytokine;Data;Dependence;Dose;Drug Delivery Systems;Drug Efflux;Drug Kinetics;efficacy evaluation;Endothelial Cells;Engineering;Erythrocytes;Formulation;Future;gene-editing approach;Genes;Gliosis;Goals;Gold;Heart;High Pressure Liquid Chromatography;Histopathology;HIV;Hour;Human;Immunohistochemistry;Impairment;improved;In Vitro;in vivo;in vivo Model;Infection;Infusion procedures;insight;Intracarotid;Intracarotid Infusion;Kidney;Kinetics;Lamivudine;Lead;light scattering;liquid chromatography mass spectrometry;liquid formulation;Liquid substance;Liver;Lung;Macaca;Macaca mulatta;Measures;Mediating;Methods;Microglia;Modeling;Monitor;Monkeys;Morphine;Mutagenicity Tests;nano;nanoGold;nanoparticle;nanoparticle delivery;nanopolymer;near infrared dye;neuroAIDS;Neuroimmune;Neurons;neuropathology;nonhuman primate;novel;Opiate Addiction;Opioid;opioid exposure;opioid use disorder;Oral;Organ;particle;Pathology;Peripheral Blood Mononuclear Cell;Pharmaceutical Preparations;Pharmacology;Plasma;Polymers;Precipitation;preference;Primates;Prognosis;Proteins;Rattus;Reporter;reproductive;Research;Rodent Model;Roentgen Rays;Route;Safety;safety assessment;Salts;Sampling;SIV;small molecule;Spleen;Sprague-Dawley Rats;subcutaneous;success;System;Testing;Therapeutic;Time;Tissues;Toxic effect;Treatment Efficacy;uptake;vector;Viral;virology;Virus Diseases;Work

PROJECT_TITLE: Ionic liquid-assisted drug delivery to brain reservoirs for treatment of neuroHIV


ORG_CITY: BRONX

ORG_NAME: JAMES J PETERS VA  MEDICAL CENTER

ORG_STATE: NY

PHR: Suicide is a major health crisis within our Veteran population. In suicide victims, the blood-brain barrier may be compromised, and understanding the biological mechanisms linking stress, the blood-brain barrier, and suicidal behavior is critical to developing diagnostic tools and preventative treatments. This study will assess the blood-brain barrier in suicide victims at the molecular and neuroanatomical levels.

PI_NAMEs: HAGHIGHI, FATEMEH G (contact)

PROJECT_TERMS: Affect;Age;age group;Anti-Inflammatory Agents;Area;Astrocytes;Autopsy;Behavioral;Biochemical;Biological;Biological Assay;Biological Markers;Blood;Blood - brain barrier anatomy;Blood specimen;Blood Vessels;blood-brain barrier crossing;blood-brain barrier disruption;blood-brain barrier function;blood-brain barrier permeabilization;Brain;Brain imaging;Cause of Death;CCL3 gene;CD44 gene;Cell Death;Cerebral cortex;cerebral microvasculature;Cerebrospinal Fluid;Cessation of life;Characteristics;Clinical;Collection;Communicable Diseases;Confounding Factors (Epidemiology);contrast enhanced;cytokine;Data;Deposition;design;Detection;Development;Diagnostic;diagnostic tool;Disease;Disease susceptibility;DNA Methylation;Dorsal;epigenetic marker;Epigenetic Process;Event;Exposure to;Extravasation;Feeling suicidal;Fibrinogen;Fibronectins;Functional impairment;Gene Expression Profiling;Genes;Genetic Polymorphism;Genetic Transcription;genome wide methylation;genome-wide;glial activation;Goals;gray matter;Health;high risk;Histologic;Hospitalization;Immune response;Immune system;Impairment;in vivo;Individual;Infection;Inflammation;Inflammatory;Intervention;Investigation;Knowledge;Laboratories;Laboratory Animals;Leukocytes;Life Stress;Link;Magnetic Resonance Imaging;Matrix Metalloproteinases;Measures;Mental Depression;Mental disorders;Metalloproteases;Methods;Methylation;methylation pattern;Microglia;military veteran;Modeling;Molecular;molecular marker;Nervous System Disorder;Neuroanatomy;Neurobiology;neuroinflammation;Neurons;Noise;Non-Invasive Detection;novel;Nucleic Acid Regulatory Sequences;Pattern;Peripheral;Persons;Phagocytes;Phenotype;Plasma Proteins;Predisposition;Prefrontal Cortex;Preventive treatment;Probability;Procedures;Process;promoter;Prospective Studies;Proteins;Proteomics;Protocols documentation;psychologic;Recording of previous events;Reporting;Research;research clinical testing;response;Risk Reduction;Sampling;Schizophrenia;schizophrenia spectrum disorder;secondary analysis;serotonin transporter;Serum;Serum Proteins;Services;sex;Signal Transduction;Site;Stress;suicidal;suicidal act;suicidal behavior;suicidal risk;Suicide;Suicide attempt;suicide attempter;suicide victim;Surface;Surveys;targeted treatment;Testing;Tight Junctions;Time;Tissue Sample;Transcript;Transcriptional Regulation;transcriptomics;Veterans;white matter

PROJECT_TITLE: Neuroinflammatory and Epigenetic Mechanisms of Blood-Brain Barrier Compromise in Suicide

STUDY_SECTION: MHBA

STUDY_SECTION_NAME: Mental Health and Behavioral Science A[MHBA]


ADMINISTERING_IC: MD

IC_NAME: NATIONAL INSTITUTE ON MINORITY HEALTH AND HEALTH DISPARITIES

NIH_SPENDING_CATS: Aging;Brain Disorders;Cerebrovascular;Clinical Research;Emergency Care;Health Disparities Research;Health Disparities and Racial or Ethnic Minority Health Research;Health Services;Neurosciences;Rural Health;Social Determinants of Health;Stroke

ORG_CITY: CHAPEL HILL

ORG_DEPT: EMERGENCY MEDICINE

ORG_NAME: UNIV OF NORTH CAROLINA CHAPEL HILL

ORG_STATE: NC

PHR: Project Narrative Improving access to acute stroke care for rural populations is critical to addressing disparities in stroke morbidity and mortality. Regional systems of emergency medical and hospital providers are essential to ensuring timely access to stroke care although current system design and triage strategies are suboptimal for rural communities. In this project, we will model and compare the effectiveness emergency triage strategies across rural settings to inform optimal stroke systems of care.

PI_NAMEs: PATEL, MEHUL D. (contact)

PROGRAM_OFFICER_NAME: STINSON, NATHANIEL

PROJECT_TERMS: access disparities;Accident and Emergency department;Acute;acute care;acute stroke;Address;Adverse effects;Behavioral;Biological;Biological Models;Bypass;care coordination;care systems;Caring;Cause of Death;Characteristics;Clinical;Communities;comparative;compare effectiveness;Complex;Computer Simulation;County;Data Sources;design;disparities in morbidity;Disparity;Emergency medical service;Emergency Situation;Ensure;Equilibrium;Evaluation;flexibility;functional outcomes;Future;Geographic Locations;Geography;Guidelines;Health Care Costs;health disparity;Healthcare;Healthcare Systems;Hospitals;Improve Access;improved;in silico;Individual;Influentials;Infrastructure;innovation;Integrated Health Care Systems;Intervention;Ischemic Stroke;Location;Long term disability;Medical emergency;Mission;Modeling;models and simulation;Morbidity - disease rate;mortality;mortality disparity;Myocardial Infarction;National Institute on Minority Health and Health Disparities;North Carolina;novel;Patient-Focused Outcomes;Patients;Performance;Population;Population Characteristics;post stroke;prospective;Protocols documentation;prototype;Provider;Publishing;Research;Resources;response;Route;Rural;rural area;Rural Community;rural counties;rural disparities;rural healthcare;Rural Population;rural setting;rural underserved;Science;screening;Sepsis;Signs and Symptoms;simulation;Source;Specialized Center;standard care;Stroke;stroke incidence;stroke outcome;stroke patient;stroke therapy;Symptoms;System;Testing;Time;Translations;Trauma;Triage;Underserved Population;underserved rural area;United States;urban area

PROJECT_TITLE: Regionalization of Acute Stroke Care for Rural Populations: A Systems Modeling Approach

STUDY_SECTION: HHD

STUDY_SECTION_NAME: Healthcare and Health Disparities Study Section[HHD]


ADMINISTERING_IC: HL

FUNDING_MECHANISM: TRAINING, INSTITUTIONAL

IC_NAME: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

NIH_SPENDING_CATS: Lung;Pediatric

ORG_CITY: PHILADELPHIA

ORG_NAME: CHILDREN'S HOSP OF PHILADELPHIA

ORG_STATE: PA

PHR: Narrative Disorders and diseases of the lung account for much of the morbidity and mortality that occurs during childhood, and the onset of lung disease in childhood is a strong predictor for respiratory disease in later life. The prevention and/or treatment of childhood respiratory diseases also has the potential to significantly reduce disease and medical costs associated with disease throughout the lifespan. Recognizing the paucity of researchers and physician scientists who focus on basic, clinical and translational research centered on pediatric lung diseases, the proposed training program will address the substantial need for academic pediatric pulmonologists and pulmonary investigators who will establish research programs and train leaders of tomorrow.

PI_NAMEs: MCGRATH-MORROW, SHARON ANN;YOUNG, LISA R. (contact)

PROGRAM_OFFICER_NAME: REYES, MADELYN

PROJECT_TITLE: Multidisciplinary Training Program in Pediatric Lung Diseases

STUDY_SECTION: NITM

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(OA)]


ADMINISTERING_IC: AI

ED_INST_TYPE: BIOMED ENGR/COL ENGR/ENGR STA

IC_NAME: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Biotechnology;Emerging Infectious Diseases;Immunization;Infectious Diseases;Influenza;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: ATLANTA

ORG_DEPT: ENGINEERING (ALL TYPES)

ORG_NAME: GEORGIA INSTITUTE OF TECHNOLOGY

PHR: Project narrative The objective of the proposed work is to develop a broadly protective influenza vaccine by engineering the protein hemagglutinin and its multivalent presentation from nanoscale scaffolds. The research is relevant to public health because it could lead to the development of new and effective vaccines that provide robust, durable, and broad protection against influenza viruses.

PI_NAMEs: KANE, RAVI S. (contact);MORENO, ALBERTO ;NEUMANN, GABRIELE

PROGRAM_OFFICER_NAME: GORDON, JENNIFER L

PROJECT_TERMS: Address;Antibodies;Antibody Response;Antigens;Avian Influenza A Virus;B-Cell Antigen Receptor;Coronavirus;design;Development;Economic Burden;endosome membrane;Engineering;Ensure;Epidemic;Epitopes;experience;Female;Ferrets;Flavivirus;global health;Glycoproteins;Head;Health;Hemagglutinin;Human;Immune response;Immunize;Immunodominant Epitopes;immunogenicity;Immunology;in vivo;Infection;Influenza;Influenza A virus;influenza infection;Influenza vaccination;influenza virus vaccine;influenzavirus;Licensing;Ligands;Location;Longevity;male;Membrane;Modeling;Mus;Mutation;nanoscale;neutralizing antibody;novel;pandemic disease;pandemic influenza;pandemic potential;pandemic virus;pathogen;Play;prophylactic;Protein Engineering;Proteins;Public Health;Research;Research Project Grants;response;Role;scaffold;seasonal influenza;Testing;Therapeutic;universal influenza vaccine;Vaccination;vaccine access;Vaccine Design;vaccine development;vaccine efficacy;vaccine immunogenicity;Vaccines;Viral;Virion;Virus;Virus-like particle;Work

PROJECT_TITLE: Engineering Protein Antigens and their Presentation from Multivalent Scaffolds

STUDY_SECTION: IHD

STUDY_SECTION_NAME: Immunity and Host Defense Study Section[IHD]


PHR: PROJECT NARRATIVE Primary B cells can be edited ex vivo to express HIV-1 broadly neutralizing antibodies and then returned to their host where, in response to a vaccine, they proliferate and affinity mature, ultimately generating potent neutralizing sera. However, efficient in vivo editing techniques are necessary to transform this technology into a viable approach for controlling an established HIV-1 infection. Here we develop novel B-cell targeting capsids, efficient editing cassettes, and potent immunogens necessary to edit B cell directly in vivo.

PI_NAMEs: CHOE, HYERYUN ;FARZAN, MICHAEL R. (contact)

PROGRAM_OFFICER_NAME: POON, BETTY

PROJECT_TERMS: adeno-associated viral vector;Affinity;Animals;Antibodies;Antigens;antiretroviral therapy;Automobile Driving;B-Cell Antigen Receptor;B-Lymphocytes;Back;BCAR1 gene;Binding;Capsid;Capsid Proteins;CAR T cell therapy;CD19 gene;Cell Proliferation;cell transformation;cell type;chimeric antigen receptor;chimeric antigen receptor T cells;Clinical;Clonal Expansion;Clustered Regularly Interspaced Short Palindromic Repeats;Code;combat;comparative;cost;delivery vehicle;demographics;Dependovirus;design;disorder control;DNA cassette;DNA Repair;Dose;Electroporation;Elements;Engraftment;Event;experience;gene therapy;Gene Transduction Agent;Genes;Genetic Engineering;Guide RNA;high risk population;HIV;HIV Antibodies;HIV Infections;HIV Seropositivity;HIV-1;Human;Immunity;Immunization;Immunoglobulin D;Immunoglobulin Idiotypes;in vivo;individual patient;Infection;Infusion procedures;innovation;Insulin Receptor;Intervention;Intravenous;intravenous administration;Laboratories;Life;Light;Lymphoid Tissue;Macaca;Macaca mulatta;manufacture;Medical;Membrane;Methods;Modification;mRNA delivery;MS4A1 gene;Mutation;nanobodies;neutralizing antibody;novel;Patient Compliance;Patients;personalized medicine;Persons;Pharmaceutical Preparations;prevent;Procedures;Proliferating;Proteins;Reagent;Recombinant adeno-associated virus (rAAV);repaired;Research;response;RNA Sequences;Safety;Serotyping;side effect;Site;social stigma;Specificity;System;Techniques;Technology;Testing;Time;tool;transduction efficiency;Translating;Tropism;Vaccinated;Vaccination;vaccination strategy;Vaccines;Variant;vector;Viral;Viremia;Writing

PROJECT_TITLE: In vivo transformation of chimeric antigen receptor B cells for a functional cure of HIV


FUNDING_MECHANISM: TRAINING, INDIVIDUAL

ORG_NAME: SCRIPPS RESEARCH INSTITUTE, THE

PHR: Project Narrative Ferroptosis is an iron-mediated, lipid peroxide propagated, non-apoptotic form of cell death that exacerbates renal vascular complications derived from type 2 diabetes and hyperglycemia. Genetic deletion of uncharacterized transmembrane protein 164 (TMEM164) robustly desensitizes renal cells to ferroptosis, protecting against programmed cell death. This proposal seeks to better understand the mechanisms by which TMEM164 regulates ferroptotic signaling, presenting researchers and clinicians a novel therapeutic target for delaying the progression of degenerative diseases.

PI_NAMEs: WARE, TIMOTHY BRANDON (contact)

PROGRAM_OFFICER_NAME: MARIC-BILKAN, CHRISTINE

PROJECT_TERMS: Acyltransferase;Apoptosis;Attenuated;attenuation;Biochemistry;Biological Assay;Cancer Model;Cell Death;Cell Death Induction;Cell membrane;Cells;Cellular biology;Cessation of life;Chemicals;Chemoresistance;Coenzyme A Ligases;Collaborations;Coupled;Cysteine;Data;Degenerative Disorder;desensitization;Diabetes Mellitus;diabetic;Diabetic Nephropathy;Disease;drug candidate;Drug Targeting;Endothelium;Enzymes;Esters;Ethers;experience;Family;Family member;fatty acid metabolism;Fatty Acids;Funding;Genes;Genetic;genome editing;glutathione peroxidase;Goals;Homeostasis;Human;human disease;hydroxy fatty acid;Hyperglycemia;inhibitor;Injury;Integral Membrane Protein;Iron;Iron Overload;Kidney;kidney cell;kidney vascular structure;Libraries;Link;lipid metabolism;Lipid Peroxidation;Lipid Peroxides;lipidomics;Lipids;Lysophosphatidylcholines;Malignant Neoplasms;Mass Spectrum Analysis;Mediating;Membrane;Metabolic;Metabolic Pathway;Methods;mutant;new therapeutic target;Non-Insulin-Dependent Diabetes Mellitus;novel;Orphan;Orthologous Gene;oxidation;Pharmaceutical Chemistry;pharmacologic;Phospholipid Metabolism;Phospholipids;Physiological;Play;Polyunsaturated Fatty Acids;Predisposition;premature;Principal Investigator;Production;Proteins;Proteomics;Recombinant Proteins;Recombinants;Renal Cell Carcinoma;Research Personnel;Risk;Role;Severities;Signal Transduction;small molecule;Structure;System;Testing;therapeutic target;Threonine;Training;Tubular formation;Variant

PROJECT_TITLE: Characterization of TMEM164 as novel multi-pass transmembrane enzyme and its role in ferroptosis


ADMINISTERING_IC: CA

IC_NAME: NATIONAL CANCER INSTITUTE

ORG_CITY: MILWAUKEE

ORG_DEPT: BIOCHEMISTRY

ORG_NAME: MEDICAL COLLEGE OF WISCONSIN

ORG_STATE: WI

PHR: This project is aimed at defining how the ESRRA-mortalin metabolic axis facilitates thyroid tumor cell proliferation and survival. We will determine whether the metabolism-sensitive transcription factor ESRRA increases mortalin expression in thyroid cancer and whether mortalin, in turn, regulates the interplay between glycolysis and the TCA cycle. We will also identify key processes in this metabolic axis and evaluate their potential as a target to suppress therapeutically challenging thyroid tumor subtypes.

PI_NAMEs: PARK, JONG-IN  (contact)

PROGRAM_OFFICER_NAME: WILLIS, KRISTINE AMALEE

PROJECT_TERMS: Acetyl Coenzyme A;Address;ATP Citrate (pro-S)-Lyase;Bioenergetics;Biology;cancer subtypes;Cell Death Induction;Cell Line;Cell Proliferation;Cell Survival;cell transformation;Cessation of life;Characteristics;Citrates;Citric Acid Cycle;clinical efficacy;Collaborations;Common Neoplasm;Data;Data Set;Development;DNA;efficacy evaluation;Enzymes;ERR1 protein;Genetic Transcription;Genus Hippocampus;Glucose;Glycolysis;Glycolysis Inhibition;Goals;GRP75;Heat-Shock Proteins 70;In Vitro;in vivo;inhibitor;Isotopes;knock-down;Maintenance;Malignant neoplasm of thyroid;Malignant Neoplasms;Mediating;Metabolic;Metabolic stress;Metabolism;metabolome;Mitochondria;Molecular;Molecular Chaperones;mortalin;NCOR1 gene;neoplastic cell;novel strategies;Oncogene Activation;Oncogenes;Oncogenic;Orphan;overexpression;Oxidative Stress;patient derived xenograft model;Patients;Process;Production;Proliferating;promoter;Pyruvate;Pyruvate Kinase;Reactive Oxygen Species;Regulation;Research;Risk;Role;Signal Transduction;Stress;stress tolerance;synergism;Testing;The Cancer Genome Atlas;Therapeutic;therapeutic target;thyroid neoplasm;transcription factor;transcriptome sequencing;Translating;tumor;Tumor Cell Line;tumor metabolism;Tumor Subtype;Up-Regulation;Warburg Effect

PROJECT_TITLE: The Role of Mortalin in Thyroid Cancer

STUDY_SECTION: TCB

STUDY_SECTION_NAME: Tumor Cell Biology Study Section[TCB]


ED_INST_TYPE: SCHOOL OF MEDICINE & DENTISTRY

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Neurodegenerative;Neurosciences

ORG_CITY: ROCHESTER

ORG_NAME: UNIVERSITY OF ROCHESTER

PHR: To help accelerate progress in the understanding, treatment, and prevention of Alzheimer’s disease and related dementias (ADRD) we propose a predoctoral training program that leverages established strengths at the University of Rochester in foundational and translational research on aging and ADRD. Through an innovative curriculum that includes memory care clinical exposure, our primary objective is to develop a cadre of early- stage scientists with the depth and breadth of knowledge, skills, appreciation, and experience necessary to establish careers as independent investigators in the area of dementia research; to work in an interdisciplinary environment designed to aggressively translate research to practice; and to reduce the toll of cognitive disorders in later life.

PI_NAMEs: O'BANION, M. KERRY (contact)

PROGRAM_OFFICER_NAME: CHAKROBORTY, SHREAYA

PROJECT_TITLE: T32 University of Rochester Aging and Alzheimer's disease Training Program


ADMINISTERING_IC: NS

IC_NAME: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

NIH_SPENDING_CATS: Neurodegenerative;Neurosciences

ORG_CITY: BIRMINGHAM

ORG_DEPT: NEUROLOGY

ORG_NAME: UNIVERSITY OF ALABAMA AT BIRMINGHAM

ORG_STATE: AL

PHR: NARRATIVE The aging of the US population will lead to unprecedented growth in the number of people affected by neurodegenerative disease. The UAB Training Program in Neurodegeneration is addressing this problem by training scientists in diverse aspects of research on neurodegeneration so that they can leverage the emerging knowledge in this field and develop the cures of the future for these common and serious disorders.

PI_NAMEs: ROBERSON, ERIK D (contact)

PROGRAM_OFFICER_NAME: WEIGAND, LETITIA ALEXIS

PROJECT_TERMS: Nerve Degeneration;Training Programs


NIH_SPENDING_CATS: Diabetes;Neurosciences;Prevention

ORG_CITY: IOWA CITY

ORG_NAME: UNIVERSITY OF IOWA

ORG_STATE: IA

PHR: PROJECT NARRATIVE According to the CDC, over 30 million Americans live with diabetes with more than a quarter of adults over 65 years suffer from its debilitating sequela. Although insulin is a commonly used and effective treatment, it comes with the risk of causing fatal hypoglycemia since most diabetic patients have impairment in glucose-regulating brain pathways that normally counteracts sharp drops in blood glucose. By investigating brain mechanisms through which hypoglycemia counterregulation is impaired, we aim to discover potential avenues of intervention to restore brain circuits that protect against fatal hypoglycemia.

PI_NAMEs: ATASOY, DENIZ  (contact)

PROGRAM_OFFICER_NAME: ARREAZA-RUBIN, GUILLERMO

PROJECT_TERMS: Ablation;Address;Adult;Affect;American;Axon;behavioral response;Blood Glucose;blood glucose regulation;Brain;brain dysfunction;brain pathway;Brain Stem;Catecholamines;Cause of Death;Cells;Cessation of life;Clinical;Coma;Communication;comorbidity;counterregulation;CSF1R gene;Dangerousness;debilitating symptom;desensitization;diabetes management;Diabetes Mellitus;diabetic patient;Disease;Dorsal;Drops;effective therapy;Equilibrium;euglycemia;Failure;feeding;Fiber;Functional disorder;genetic manipulation;glial activation;Glucose;glycemic control;Goals;Grant;Health Care Costs;Hormonal;human old age (65+);Hunger;Hypoglycemia;hypoglycemia unawareness;Hypothalamic structure;Impairment;improved;in vivo;Individual;insight;Insulin;Intervention;Knowledge;Life;Malignant - descriptor;Maps;Measures;Medial;Mediating;Microglia;Molecular;mortality;neural circuit;Neurons;new therapeutic target;Norepinephrine;novel;optogenetics;Outcome;paraventricular nucleus;Pathology;Pathway interactions;Persons;Photometry;Physiological;prevent;productivity loss;real-time images;Recurrence;Regulatory Pathway;Research;response;Reverse Transcriptase Polymerase Chain Reaction;Risk;Role;Series;Signal Transduction;single-cell RNA sequencing;Therapeutic

PROJECT_TITLE: Targeting Ascending Catecholamine Pathways to Prevent Hypoglycemia

STUDY_SECTION: IPOD

STUDY_SECTION_NAME: Integrative Physiology of Obesity and Diabetes Study Section[IPOD]


NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Neurosciences;Physical Rehabilitation;Rehabilitation

ORG_CITY: CAMBRIDGE

ORG_DEPT: BIOLOGY

ORG_NAME: HARVARD UNIVERSITY

PHR: Narrative The ability to learn and execute motor skills is central to our everyday existence. Our reliance on motor skills leaves us vulnerable to neurological disorders and strokes that affect the neural circuits involved in their acquisition and control. Our research goal is to identify these circuits, delineate their respective functions, and explain the logic by which they work together to implement motor skill learning and execution. This work will inform the design of new therapeutics and neurorehabilitation paradigms for patients with motor disabilities.

PI_NAMEs: OLVECZKY, BENCE P (contact)

PROGRAM_OFFICER_NAME: CHEN, DAOFEN

PROJECT_TERMS: Acute;Address;Affect;Anatomy;Animals;Arbitration;Back;Basal Ganglia;Behavior;Behavioral;Brain region;Brain Stem;Chronic;clinical practice;Code;Complex;Corpus striatum structure;design;Future;Generations;Goals;Grain;Infrastructure;innovation;instrument;kinematics;learned behavior;Learning;Learning Skill;Logic;Maps;Measurement;Measures;Midbrain structure;Modeling;Monitor;Motion;Motor;motor control;Motor Cortex;Motor disability;Motor output;motor skill learning;Motor Skills;Movement;Nervous System Disorder;neural;neural circuit;neurological rehabilitation;Neurons;Neurosciences;novel therapeutics;optogenetics;Output;Pathway interactions;Patients;Pattern;Phylogenetic Analysis;Physiological;Play;Policies;Process;programs;Property;Rattus;Recurrence;Research;Resolution;Rodent;Role;Rostral Intralaminar Nuclei;Scheme;skill acquisition;skills;skills training;Specific qualifier value;Sports;Stereotyping;Stroke;Structure;System;Testing;Thalamic structure;Time;Training;Work;Writing

PROJECT_TITLE: Neural Circuits Underlying the Acquisition and Control of Motor Skills

STUDY_SECTION: SMN

STUDY_SECTION_NAME: Sensory-Motor Neuroscience Study Section[SMN]


ORG_NAME: UNIVERSITY OF PENNSYLVANIA

PHR: PROJECT NARRATIVE Alzheimer’s disease and related dementias (ADRD) are a leading cause of neurological disability. Because of its ability to resolve brain structure and function noninvasively, neuroimaging has become a leading strategy used for translational research in ADRD and a prominent biomarker strategy for clinical differential diagnosis of ADRD, for defining preclinical stages of ADRD, and for evaluating for target engagement and therapeutic responses in trials. This cross-disciplinary training program in translational neuroimaging of ADRD aims to leverage the University of Pennsylvania’s longstanding track record of innovation and translation in biomedical neuroimaging in ADRD to increase training for the current and emerging generation of researchers in neuroimaging approaches that have potential to impact cognitive impairment and dementia including neuropathology, translational research, drug discovery, and clinical trials of ADRD.

PI_NAMEs: DETRE, JOHN A;GROSSMAN, MURRAY ;MCMILLAN, COREY T (contact)

PROGRAM_OFFICER_NAME: LUO, YUAN

PROJECT_TERMS: Alzheimer's disease related dementia;neuroimaging;Training

PROJECT_TITLE: Cross-disciplinary training in translational neuroimaging of ADRD


NIH_SPENDING_CATS: Aging

PHR: The primary purpose of the training program based in the University of North Carolina Center for Aging and Health is to continue to nurture the development of future physician (allopathic and osteopathic) leaders in research related to aging. The nation’s biggest public health challenge for the coming decades is how to best care for our burgeoning population of persons aged 65 and older – particularly those who are living with multiple chronic conditions and disabilities. This training grant is designed to build on the success of our current funded program by increasing the number of physicians who are trained to conduct important research related to aging, which can help solve critical problems around the care of older persons.

PI_NAMEs: BUSBY-WHITEHEAD, JAN  (contact)

PROGRAM_OFFICER_NAME: JOSEPH, LYNDON

PROJECT_TERMS: Affect;Aging;aging process;aging related;American;Area;Arts;Behavioral;Biological;career;Career Mobility;Clinical;Collaborations;college;Complex;Data Analyses;Dedications;design;disability;Discipline of Nursing;Disease;Economics;Ensure;Ethics;experience;faculty mentor;Foundations;Funding;Genetic;Geriatrics;Gerontology;Goals;Health;Health Services;improved;interest;Knowledge;lectures;Literature;Manuscripts;Medical;medical schools;Medical Students;Medicine;Mentors;Mission;Nature;older adult;Osteopathic Medicine;Outcome;Performance;Pharmacy facility;Physicians;pre-doctoral;Preparation;programs;Public Health;recruit;Research;research and development;Research Project Grants;Research Training;Resources;responsible research conduct;role model;Science;Scientist;skills;social;Social Work;Structure;Students;success;summer research;Training;Translating;Vision;Work

PROJECT_TITLE: UNC-CH Summer Research Training in Aging for Medical Students


ED_INST_TYPE: OTHER SPECIALIZED SCHOOLS

NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Clinical Research;Clinical Trials and Supportive Activities;Dementia;Genetics;Immunization;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza;Prevention;Vaccine Related

ORG_CITY: DURHAM

ORG_NAME: DUKE UNIVERSITY

PHR: Narrative Accumulating evidence suggests that infections could play an important role in Alzheimer’s disease (AD), however, exact mechanism is unclear. The goal of this project is to significantly improve our understanding of mechanisms connecting AD and common infections, and suggest new candidates for AD prevention based on repurposing of existing adult vaccines, using large samples of existing population-based human data.

PI_NAMEs: OUKRAINTSEVA, SVETLANA V. (contact)

PROGRAM_OFFICER_NAME: MARIC, MAJA

PROJECT_TERMS: Address;Adult;Affect;Aging;Alzheimer disease prevention;Alzheimer Vaccines;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease risk;Alzheimer’s disease biomarker;Bacteria;Bacterial Pneumonia;blood-brain barrier permeabilization;Brain;Candidate Disease Gene;candidate selection;Clinical;Clinical Trials;Cognitive;Communicable Diseases;Data;Dementia;Diabetes Mellitus;Diagnosis;Disease;disorder prevention;disorder risk;Etiology;flu;fungus;Genes;Genetic;Genetic Predisposition to Disease;Genotype;Goals;Health;Herpes Simplex Infections;Herpes zoster disease;human data;human old age (65+);Immune response;Immunity;improved;Individual;Infection;Link;Literature;Lymphocyte Activation;Malignant Neoplasms;Microbe;microbial;microorganism;mortality;mortality risk;Mycoses;Myelin;Natural Immunity;Nerve Degeneration;older adult;Older Population;online resource;Onset of illness;pathogen;Pathway interactions;Permeability;Play;Pneumonia;population based;Preventive measure;Proliferating;protective factors;Proxy;Randomized;randomized, clinical trials;Recurrence;repaired;resilience;Resistance;response;Risk Estimate;Risk Reduction;Role;Sampling;Selection Criteria;seropositive;Serum;Specific qualifier value;Stroke;Techniques;Testing;Toxin;Training;trait;TREM2 gene;Vaccination;vaccine candidate;Vaccines;Virus

PROJECT_TITLE: Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention


NIH_SPENDING_CATS: Congenital Structural Anomalies;Genetics;Human Genome;Kidney Disease;Pediatric;Polycystic Kidney Disease

ORG_CITY: STONY BROOK

ORG_NAME: STATE UNIVERSITY NEW YORK STONY BROOK

PHR: NARRATIVE The goal of this project is to understand the functions of a protein named HNF-1β in the kidney. Mutations of HNF-1β produce cystic kidney disease and renal failure in humans. The proposed studies will probe the normal functions of HNF-1β and determine how mutations produce kidney abnormalities.

PI_NAMEs: IGARASHI, PETER  (contact)

PROJECT_TERMS: Ablation;Adhesives;Affect;autosome;beta catenin;Binding;Biochemical;Cell Proliferation;Cells;CHD4 gene;ChIP-seq;Chromatin Loop;chromatin modification;chromatin remodeling;Chromatin Remodeling Factor;chromosome conformation capture;Complex;congenital anomalies of the kidney;Couples;Cyclic AMP;Cyst;Cystic Kidney Diseases;Deposition;derepression;Disease;Distal;DNA;DNA Binding;Enhancers;Epithelial Cells;Epithelium;EZH2 gene;fibrogenesis;Fibrosis;Gene Expression;Gene Expression Regulation;gene repression;Genes;Genetic;Genetic Transcription;genome-wide;Genomics;Goals;Growth;Health;hepatocyte nuclear factor;Hi-C;Histone Acetylation;histone methylation;histone modification;Histones;Human;Immunoprecipitation;improved;in vivo evaluation;indexing;Individual;Inherited;insight;interstitial;Kidney;kidney cell;Kidney Diseases;Kidney Failure;kidney fibrosis;Ligands;lipid metabolism;lymphoid enhancer-binding factor 1;Mass Spectrum Analysis;Measures;Messenger RNA;Molecular;mouse genetics;mouse model;Mus;mutant;mutant mouse model;Mutant Strains Mice;Mutation;Names;nephrogenesis;novel;NuRD complex;Organ;overexpression;palmitoylation;Pathogenesis;Pathway interactions;Phenotype;Phosphorylation;Play;Polycomb;Polycystic Kidney Diseases;Polymerase;promoter;Proteins;recruit;Regulation;renal epithelium;Renal function;Repression;RNA Polymerase II;Role;Signal Pathway;Signal Transduction;Structure;Testing;therapeutic target;Tissue-Specific Gene Expression;trafficking;Transcription Elongation;transcription factor;Transcriptional Regulation;transcriptome sequencing;Untranslated RNA;urinary;Urinary tract;Wnt proteins;WNT Signaling Pathway;WNT9A gene;Work

PROJECT_TITLE: Regulation of Kidney-Specific Gene Expression

STUDY_SECTION: PBKD

STUDY_SECTION_NAME: Pathobiology of Kidney Disease Study Section[PBKD]


NIH_SPENDING_CATS: Cardiovascular

ORG_CITY: PITTSBURGH

ORG_NAME: UNIVERSITY OF PITTSBURGH AT PITTSBURGH

PHR: PROJECT NARRATIVE Imaging in the biomedical sciences – from the individual molecule to the entire body – is a critical component of research which drives some of the most important discoveries of our time. The development of imaging technologies by scientists should be informed by a knowledge of the important targets around which to develop an imaging strategy and conversely, biomedical researchers should be fluent in the broad range of imaging platforms available to optimally design their studies – a reciprocal relationship that will foster the kind of scientific discovery that can be translated to the bedside. This Program aims to train post-doctoral fellows to acquire core competency in imaging technologies across a broad spectrum, to achieve fundamental proficiency in tools for translational research spanning basic to clinical investigation, and to use these tools to pursue hypothesis-driven research, with a focus on cardiovascular medicine.

PI_NAMEs: VILLANUEVA, FLORDELIZA S (contact)

PROGRAM_OFFICER_NAME: WOO, SEUNG KYOON

PROJECT_TITLE: Training Program in Imaging Sciences in Translational Cardiovascular Research

STUDY_SECTION_NAME: NHLBI Institutional Training Mechanism Study Section[NITM(JA)]


NIH_SPENDING_CATS: Cancer;Cancer Genomics;Colorectal Cancer;Digestive Diseases;Genetics;Human Genome

ORG_CITY: HACKENSACK

ORG_NAME: HACKENSACK UNIVERSITY MEDICAL CENTER

ORG_STATE: NJ

PHR: Project Narrative Colorectal Cancer is the 3rd most prominent cancer found in men and women, and is the second leading cause of cancer-related deaths in the United States. My proposed research aims to dissect the molecular pathways that regulate colon cancer progression and metastasis. I hope that these studies will indentify new molecular targets that translate into new, more effective treatments for cancers.

PI_NAMEs: TONG, KEVIN  (contact)

PROGRAM_OFFICER_NAME: XU, WANPING

PROJECT_TERMS: Acceleration;Address;adenoma;anti-cancer research;Award;beta catenin;Binding;Binding Sites;Bioinformatics;Biological Models;BRAF gene;Cancer Etiology;cancer genome;Cancer Model;cancer therapy;cancer type;Carcinoma;Cell Nucleus;Cessation of life;ChIP-seq;clinically relevant;colon cancer cell line;colon cancer patients;colon cancer progression;Colon Carcinoma;Colonic Neoplasms;Colorectal Cancer;Data;Development;Disseminated Malignant Neoplasm;DNA Binding;DNA Sequence Alteration;Dysplasia;effective therapy;Environment;epigenomics;Fortification;Foundations;Future;gain of function;Gene Expression;Gene Targeting;Genes;Genetic;Genetic Transcription;Genome;Goals;Hyperplasia;in vivo;insight;Institution;Kinetics;Knowledge;Laboratory Research;Lesion;MADH4 gene;Malignant Neoplasms;Maps;Measurement;Measures;men;Mentorship;Modeling;Molecular;Molecular Target;mouse model;Mus;mutant;Mutate;Mutation;Neoplasm Metastasis;novel;Nucleic Acid Regulatory Sequences;Oncogenic;Organoids;Pathology;Pathway interactions;Patients;Phase;Play;post-doctoral training;Prognosis;programs;Research;Resources;Role;role model;RUNX3 gene;Science;screening;Shapes;Signal Pathway;skills;Solid Neoplasm;System;Testing;therapeutic target;Tissues;tool;Training;transcription factor;Transforming Growth Factor beta;Translating;Transplantation;tumor;tumor progression;Tumor Subtype;Tumor Suppressor Genes;Tumor Suppressor Proteins;Tumor Tissue;tumorigenesis;United States;Universities;WNT Signaling Pathway;Woman

PROJECT_TITLE: Elucidating the Role of SMAD4 in Colorectal Cancer

STUDY_SECTION: NCI

STUDY_SECTION_NAME: Transition to Independence Study Section (I)[NCI-I]


NIH_SPENDING_CATS: Neurosciences

ORG_DEPT: ANATOMY/CELL BIOLOGY

ORG_NAME: MOREHOUSE SCHOOL OF MEDICINE

PHR: The BS/MS Program in Neuroscience at the Atlanta University Consortium has the long-term goal of increasing under-represented minorities in the field of Neuroscience. This three-year program takes Juniors in college and trains them in Neuroscience research through coursework and laboratory work. At the end, these students receive a master’s degree and experience that will help them succeed as Ph.D. scientists or physicians interested in Neuroscience research.

PI_NAMEs: BENVENISTE, MORRIS J. (contact)

PROGRAM_OFFICER_NAME: ULLRICH, LAUREN ELIZABETH

PROJECT_TERMS: Abbreviations;Active Learning;African American;African American population;Applications Grants;Area;Biological Sciences;Black American;Black Populations;Black race;career;Censuses;Collaborations;college;Complex;Creativeness;Critical Thinking;Data;Degree program;Development;Disparity;disparity gap;Doctor of Medicine;Doctor of Philosophy;Doctor's Degree;doctoral student;Education;Educational Curriculum;Educational process of instructing;Enrollment;Environment;Evaluation;Exercise;experience;Experimental Designs;Exposure to;falls;Federal Government;Fellowship;Fortification;Funding;Goals;graduate student;Grant;Grant Review;Growth;Health;health inequalities;Healthcare;Historically Black Colleges and Universities;Home;improved;Institution;interest;Laboratories;Laboratory Research;Learning;lectures;Literature;Master of Science;medical schools;Mentors;Minority Groups;Morehouse School of Medicine;National Institute of Neurological Disorders and Stroke;Neurology;Neurosciences;Neurosciences Research;neurosurgery;Occupations;Physicians;Population;Positioning Attribute;Postdoctoral Fellow;pre-doctoral;Preparation;Probability;programs;Publications;Qualifying;recruit;Research;Research Personnel;Research Project Grants;Science;Science, Technology, Engineering and Mathematics;Scientist;skills;Societies;Source;stem;Student recruitment;Students;success;System;Talents;Thinking;Time;Training;undergraduate student;Underrepresented Minority;underrepresented minority student;United States;United States National Institutes of Health;Universities;Vocational Guidance;Walking;Work


ORG_DEPT: GENETICS

PHR: Signaling Aberrations and Cerebral Cavernous Malformations Pathogenesis Cerebral Cavernous Malformations (CCM) are blood vessel abnormalities occurring in the brain. The CCMs can bleed and cause seizures or strokes. In this renewal application of a program project, four leading laboratories working on this disease will continue our investigation into the underlying processes that cause the CCMs to form, and to cause them to bleed. Using mice that we have genetically engineered to have the disease and comparing these animals with tissue and blood from human CCM patients, we will work towards a fuller understanding of the disease with the goal of generating new ideas for therapy.

PI_NAMEs: MARCHUK, DOUGLAS A. (contact)

PROGRAM_OFFICER_NAME: UTZ, URSULA

PROJECT_TERMS: activated protein C receptor;Acute;ADAMTS;Affect;American;Animals;Anticoagulants;autosome;Blood;Blood capillaries;Blood Vessels;Brain;cell behavior;Cell Lineage;Cells;cerebral cavernous malformations;Chronic;Clinical Trials;clinically significant;Collection;Communities;Complex;Cytoprotection;Data;design;Development;Disease;drug testing;Endothelial Cells;Endothelium;Environment;Event;Exhibits;follow-up;gain of function;Genes;Genetic Engineering;genomic locus;Genotype;Goals;Growth;gut microbiome;Hemorrhage;Histology;Human;insight;Investigation;Laboratories;Lesion;Lesion by Stage;lifetime risk;Modeling;Molecular;molecular marker;Molecular Probes;Molecular Profiling;mouse model;Mus;mutant;Mutate;Mutation;Neurologic;new therapeutic target;novel;novel marker;Operative Surgical Procedures;overexpression;Pathogenesis;Pathologic;Pathway interactions;Patients;Pharmaceutical Preparations;pharmacologic;Phenotype;PIK3CG gene;Play;Poison;pre-clinical;Preparation;Process;programs;Protein C;recruit;Role;Seizures;Signal Pathway;Signal Transduction;single cell genomics;Somatic Mutation;Specimen;Stroke;stroke risk;success;Testing;Therapeutic Studies;therapeutic target;Thrombomodulin;Tissues;TLR4 gene;tool;transcriptomics;versican;Work;X-Ray Computed Tomography

PROJECT_TITLE: Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis


PHR: NARRATIVE – ADMINSTRATIVE CORE Signaling Aberrations and Cerebral Cavernous Malformation Pathogenesis The Administrative Core plays a critical role in the multi-institutional program of research. The Core staff facilitate and maintain communication among the project members and the NIH, manage research progress and timelines, and manage fiscal and other resources across the sites.

PROJECT_TERMS: cerebral cavernous malformations;Communication;Contracts;data management;Doctor of Philosophy;Ensure;Fostering;Funding;Goals;Infrastructure;Institution;Lead;meetings;member;Monitor;National Institute of Neurological Disorders and Stroke;Nature;Occupational activity of managing finances;Pathogenesis;Play;Policies;Preparation;Procedures;programs;Reporting;Research;Research Activity;Research Personnel;Resources;Role;Signal Transduction;Site;Teleconferences;timeline;United States National Institutes of Health;Work

PROJECT_TITLE: Administrative Core


PHR: NARRATIVE – CORE A, UNIVERSITY OF CHICAGO A program project linking four leading investigators at separate institutions has facilitated exceptional discoveries regarding cerebral cavernous malformations, which cause brain bleeding, and lack effective therapy. We propose a next phase of discovery aiming at remaining knowledge gaps, and the translation to novel human therapies and biomarkers. A Phenotyping, Human Tissue and Biomarkers Core has been assembled, to enhance synergy, collaboration, efficiency and rigor, and to facilitate clinical translation of the respective projects.

PI_NAMEs: AWAD, ISSAM A (contact)

PROJECT_TERMS: activated Protein C;Acute;ADAMTS;adjudication;Affect;American;Anticoagulants;Articulation;atorvastatin;biobank;Biological Markers;Biological Specimen Banks;biomarker discovery;biomarker validation;Blinded;Blood capillaries;Blood Vessels;Brain;brain control;Caenorhabditis elegans;candidate marker;Cavernous Hemangioma;CD14 gene;cell free DNA;Cells;cerebral cavernous malformations;Chicago;Chronic;Clinical;clinical translation;clinically relevant;Clonal Expansion;cohort;Collaborations;Collection;Cytoprotection;Data;data structure;Densitometry;Development;Diet;dietary supplements;differential expression;Discipline;Disease;Dissection;DNA analysis;Dose;effective therapy;Endothelium;Ensure;Environmental Risk Factor;Epilepsy;Evaluation;exosome;experimental study;Familiarity;Gene Silencing;Genes;Genotype;Germ Lines;Hand;Hemangioma;Hemorrhage;Human;human subject;Human Subject Research;human tissue;Hypoxia;immunohistochemical markers;Infiltration;Inflammatory;innovation;Institution;Intestines;Investigational Therapies;Iron;Knowledge;Laboratories;Lasers;Lesion;Libraries;lifetime risk;Link;metabolomics;microbiome;microCT;MicroRNAs;Modeling;molecular marker;Molecular Probes;Molecular Profiling;Monitor;mouse model;Mucins;Mus;Mutate;Mutation Analysis;neurovascular unit;next generation;novel;novel therapeutics;Ontology;Operative Surgical Procedures;Organism;Outcome;Pathogenesis;Pathway interactions;Patients;peripheral blood;Pharmaceutical Preparations;Phase;Phenotype;Phosphotransferases;PIK3CG gene;placebo controlled trial;Plasma;Plasma Proteins;prevent;primary outcome;programs;prospective;protein expression;Proteins;Proteolysis;Protocols documentation;Research Personnel;Resected;Rho-associated kinase;risk stratification;RNA analysis;Role;Sample Size;Sampling;secondary outcome;Services;Severity of illness;Signal Transduction;Site;Somatic Mutation;Specimen;Stains;Statistical Methods;statistics;Stimulus;stroke risk;synergism;Techniques;Thrombomodulin;Thrombospondin 1;Thrombospondins;TLR4 gene;tool;transcriptomics;Translating;Translations;trial readiness;Universities;Validation;versican;Work


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Dementia;Infectious Diseases;Lung;Neurodegenerative;Neurosciences;Pneumonia;Pneumonia and Influenza

ORG_CITY: LOS ANGELES

ORG_NAME: CEDARS-SINAI MEDICAL CENTER

PHR: PROJECT NARRATIVE Recent data has emerged which suggests a relationship between certain infectious agents and Alzheimer's Disease development and progression. Among these agents, Chlamydia pneumoniae stands out as one of the most likely to be involved. In this proposal we seek to understand what potential role C. pneumoniae infection may play in AD using mouse models.

PI_NAMEs: CROTHER, TIMOTHY ROBERT (contact);KORONYO-HAMAOUI, MAYA

PROJECT_TERMS: Acceleration;Acute;Address;Alzheimer like pathology;Alzheimer's Disease;Alzheimer's disease brain;Alzheimer's disease pathology;Alzheimer's disease patient;American;Amyloid beta-42;Amyloid beta-Protein;Antibiotic Therapy;Antibody titer measurement;Antigens;Asthma;Atherosclerosis;Autopsy;Bacteria;Biological Markers;Brain;Cause of Death;Cell model;Chlamydial pneumonia;Chlamydophila pneumoniae;Chronic;chronic inflammatory disease;Cognition;community acquired pneumonia;cytokine;Data;Data Analyses;Development;Disease;Disease Progression;Early Onset Alzheimer Disease;Economic Burden;Elderly;Emotional;Future;Genetic;Goals;IL17 gene;Immune response;Infection;Infectious Agent;Inflammasome;Inflammation;Inflammatory;Interleukin-1 beta;Investigation;Late Onset Alzheimer Disease;Link;Location;Long-Term Effects;Lung;Malignant neoplasm of lung;Mediating;Microglia;mild cognitive impairment;mouse model;Mus;Nerve Degeneration;new therapeutic target;novel therapeutic intervention;novel therapeutics;Outcome;Paper;pathogen;Pathogenesis;pathogenic microbe;Pathogenicity;Pathologic;Pathology;Play;Positioning Attribute;Production;Publishing;Qualifying;Research;Research Personnel;Retina;Role;Senile dementia;Severities;Source;Spatial Distribution;T-Lymphocyte;Testing;trend;Visit

PROJECT_TITLE: The role of Chlamydia pneumoniae infection in Alzheimer's Disease


ORG_CITY: ANN ARBOR

ORG_NAME: UNIVERSITY OF MICHIGAN AT ANN ARBOR

ORG_STATE: MI

PHR: PROJECT NARRATIVE This program will establish a pipeline of outstanding physician scientists in in age-related diseases. We will leverage the considerable resources at the University of Michigan in medical education, biomedical research and public policy as well as a talented pool of preceptors, supported by various NIH-funded centers, to attract physician scientists at the end of their clinical training (post-doctoral trainees). Our multi-disciplinary training program for physician scientists will prepare them for careers in medicine with the ultimate goal to improve the health of the ever-expanding older population.

PI_NAMEs: MIN, LILLIAN CHIANG;MODY, LONA  (contact);YUNG, RAYMOND L

PROGRAM_OFFICER_NAME: SALIVE, MARCEL

PROJECT_TITLE: Physician Scientist Training in Age-Related Diseases


PHR: NARRATIVE – PROJECT 1 Cerebral Cavernous Malformations (CCM) are blood vessel abnormalities occurring in the brain. The CCMs can bleed and cause seizures or strokes. In the past we learned that the cells in the malformed blood vessels acquire mutations in specific genes; sometimes in multiple genes. In this project we will broaden our search for these mutations in additional genes, and determine whether individual cells acquire more than one mutation. In addition, we will characterize the gene expression pattern of the mutant and normal cells in the malformations to determine if the mutant cells can alter the normal cells to recruit them into the growing CCM. Finally, using mice that we have genetically engineered to have the CCM disease, we will continue our quest for an effective treatment - testing candidate drugs coming from ideas generated by the program project team.

PROJECT_TERMS: AKT Signaling Pathway;Blood Vessels;Brain;cell behavior;Cell Compartmentation;Cell Lineage;Cell Separation;Cells;cerebral cavernous malformations;Clinical Trials;clinically relevant;Clonal Expansion;Code;Data;Development;Disease;DNA Resequencing;DNA sequencing;Doctor of Philosophy;drug candidate;drug repurposing;effective therapy;Endothelial Cells;Event;exome sequencing;Exons;experience;Funding;gene discovery;Gene Expression Profile;Genes;Genetic Engineering;Genotype;Goals;Growth;Hemangioma;Hemorrhage;Human;human tissue;improved;Individual;Knowledge;Laboratories;Learning;Lesion;malformation;Malignant Neoplasms;Modeling;Molecular;mouse model;Mus;mutant;Mutate;Mutation;new therapeutic target;Normal Cell;novel;novel therapeutics;Oncogenes;Operative Surgical Procedures;Pathogenesis;Patients;Pattern;Pharmaceutical Preparations;Phenotype;PIK3CA gene;PIK3CG gene;Poison;Population;programs;Proto-Oncogene Proteins c-akt;Publishing;recruit;Research Personnel;Resected;Role;Route;Seizures;Signal Pathway;Signal Transduction;single cell genomics;single-cell RNA sequencing;Somatic Mutation;Source;Stroke;Testing;Therapeutic;Tissue Banks;transcriptomics;Work

PROJECT_TITLE: Somatic mutation(s) and cellular changes in CCM pathogenesis


PHR: Cerebral Cavernous Malformations (CCM) are a common neurovascular disease caused by loss of function of genes such as KRIT1 and for which there is no specific pharmacological therapy. Bleeding into the brain is a major cause of symptoms of this disease. These studies are testing the idea that over activity of a mechanism that normally prevents blood clots contributes to bleeding in CCM. This research will define new mechanisms for CCM pathogenesis and may lead to new therapeutic targets in CCM disease.

PI_NAMEs: GINSBERG, MARK HOWARD (contact)

PROJECT_TERMS: activated Protein C;activated protein C receptor;Acute;Adult;Anticoagulants;Blocking Antibodies;Blood coagulation;Blood Vessels;Brain;CCM1 gene;cerebral cavernous malformations;Chronic;Cytoprotection;Deposition;Development;Disease;Disease Progression;Endothelial Cells;Endothelium;F2R gene;factor V Leiden;Factor V Leiden mutation;gene function;Hemophilia A;Hemorrhage;Hemosiderin;Human;Hypoxia;Hypoxia Inducible Factor;Impairment;insight;Intercellular Junctions;Intervention;Lesion;loss of function;Modeling;Monoclonal Antibodies;Morbidity - disease rate;mortality;MSH2 gene;Mus;mutant;neonatal mice;neurovascular;new therapeutic target;Pathogenesis;Pathway interactions;Perinatal;pharmacologic;Preclinical Testing;prevent;Protein C;Research;Resistance;Role;Sepsis;Signal Transduction;Source;Stroke;Symptoms;Testing;therapeutic target;Thrombomodulin

PROJECT_TITLE: Anti-Coagulant and Cytoprotective activity in CCM pathogenesis


ORG_CITY: SALT LAKE CITY

ORG_NAME: UNIVERSITY OF UTAH

ORG_STATE: UT

PHR: Narrative: Nocturnal hypertension accounts for one third of the hypertensive cases and represents an important risk factor of cardiovascular disease and target organ damage. The current proposal has the potential to advance our understanding of the fundamental mechanism of circadian rhythm of blood pressure and also to identify a novel target for treatment of circadian disorder in the cardiovascular system.

PI_NAMEs: YANG, TIANXIN  (contact)

PROGRAM_OFFICER_NAME: VARAGIC, JASMINA

PROJECT_TERMS: Adipose tissue;Agonist;Blood Pressure;blood pressure regulation;Cardiovascular Diseases;cardiovascular risk factor;Cardiovascular system;circadian;Circadian Dysregulation;circadian regulation;Circadian Rhythms;Communication;Data;diet-induced obesity;Disease;Distal convoluted renal tubule structure;Diurnal Rhythm;Excretory function;Exhibits;Histidine;hypertensive;Impairment;improved;In Vitro;in vitro activity;in vivo;Kidney;Mediating;Metabolic;Modeling;Mus;Mutagenesis;Nephrons;Nocturnal Hypertension;novel;Obese Mice;Organ;Periodicity;Phenotype;Phosphoric Monoester Hydrolases;Phosphorylation;PPAR gamma;Protein Dephosphorylation;receptor;receptor function;Receptor Signaling;Renal function;Role;Signal Pathway;Site;Source;Surrogate Markers;symporter;Testing;Type 2 Angiotensin II Receptor;Variant

PROJECT_TITLE: Adipose-derived sPRR controls circadian rhythm of blood pressure through inhibition of renal NCC activity

STUDY_SECTION: IVPP

STUDY_SECTION_NAME: Integrative Vascular Physiology and Pathology Study Section[IVPP]


ADMINISTERING_IC: HD

IC_NAME: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT

NIH_SPENDING_CATS: Biotechnology;Contraception/Reproduction;Genetic Testing;Genetics;Human Genome;Infertility;Prevention;Women's Health Research

ORG_CITY: PISCATAWAY

ORG_NAME: RUTGERS, THE STATE UNIV OF N.J.

PHR: Project Narrative Infertility affects 1 out of 6 couples in the U.S, often resulting from aneuploidy, a genetic abnormality in which a cell contains an improper number of chromosomes. The incidence of aneuploidy increases with maternal age; however, there is enormous variation in the frequency at any given age. This study aims to identify genes in the maternal genome that correlate with risk of aneuploidy and evaluate their functional significance in reproduction in model organisms.

PI_NAMEs: SCHINDLER, KAREN A (contact);XING, JINCHUAN

PROGRAM_OFFICER_NAME: TAYMANS, SUSAN

PROJECT_TERMS: Affect;Age;Aneuploidy;aneuploidy analysis;Automobile Driving;biobank;Biological Assay;Biological Markers;Biological Models;Biology;biomarker identification;Biopsy;blastocyst;Caenorhabditis elegans;Candidate Disease Gene;candidate identification;candidate validation;causal variant;Cells;Chromosome Segregation;Chromosomes;Clinic;clinical care;Clustered Regularly Interspaced Short Palindromic Repeats;Conceptions;Couples;Data;Data Set;Disease;egg;Embryo;Embryo Transfer;empowerment;Etiology;Evaluation;exome;Female;Fertility;fly;Frequencies;Genes;Genetic;genetic analysis;Genetic Markers;Genetic Models;genetic resource;Genetic Risk;genetic risk factor;genetic variant;Genome;genome editing;genome sequencing;Germ Cells;Germ Lines;Goals;Grant;High Risk Woman;Homologous Gene;Human;human female;In Vitro;in vivo;Incidence;Individual;Infertility;infertility treatment;innovation;Knock-in Mouse;Knowledge;Mammals;Maternal Age;maternal risk;Meiosis;method development;Methods;model organism;Molecular;Molecular Abnormality;mouse genetics;mouse model;Mus;Mutation;novel;oocyte quality;Oocytes;Outcome;Pathway interactions;Phenotype;potential biomarker;preimplantation;Preimplantation Diagnosis;preservation;Prevalence;prevent;Process;programs;Public Health;Regulatory Pathway;Reproduction;Research;Research Personnel;Risk;Risk Marker;risk prediction;Role;Spontaneous abortion;success;System;Testing;Treatment Failure;United States;Validation;Variant;variant of interest;whole genome;Woman;Work

PROJECT_TITLE: Understanding genetic risk for aneuploid conception


ADMINISTERING_IC: GM

IC_NAME: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

NIH_SPENDING_CATS: Biodefense and Related Countermeasures;Emerging Infectious Diseases;Infectious Diseases

ORG_CITY: BOSTON

ORG_NAME: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)

PHR: Antibiotic-resistant bacteria continue to emerge in the human population, reducing treatment options for patients, and prompting researchers to look for novel bacterial targets in order to develop effective treatments. Glycosyltransferases (GTs) are enzymes that are responsible for diversifying the glycan portion of bacterial glycoconjugates, which are essential for bacterial viability and pathogenicity, and represent a viable antibiotic target. The proposed biochemical and biophysical methods will determine structural factors that can be used to determine which glycans GTs act upon and how best to direct therapeutics against them.

PI_NAMEs: VUKSANOVIC, NEMANJA  (contact)

PROGRAM_OFFICER_NAME: SIMONOVIC, MILJAN

PROJECT_TITLE: Structural and functional characterization of glycosyltransferases in the Campylobacter concisus N-linked glycoconjugate biosynthetic pathway


PHR: NARRATIVE – PROJECT 3 Cerebral cavernous malformation (CCM) is a common cause of stroke for which there is no drug therapy. Studies from our group and others over the past 5 years have defined an upstream pathway by which cerebral cavernous malformations arise, but the downstream mechanisms and potential downstream drug targets remain unknown. Our preliminary studies in mice and humans identify two novel downstream mechanisms for CCM formation: gain of PI3K signaling and proteolytic cleavage of the matrix proteoglycan versican. This proposal will use established and new mouse models to test the role of these downstream pathways and determine whether existing FDA-approved agents such as rapamycin can be used to treat CCM disease.

PI_NAMEs: KAHN, MARK L (contact)

PROJECT_TERMS: ADAMTS;Address;Blood Vessels;brain endothelial cell;cardiogenesis;Cavernous Hemangioma;cell growth;Cell Proliferation;Cells;cerebral cavernous malformations;Cerebrovascular system;Clinic;Clinical;Collaborations;Complement;Complex;Development;Disease;Drug Targeting;Embryo;Endothelial Cells;Endothelium;Event;FDA approved;gain of function;Genes;Genetic Models;Gram-Negative Bacteria;gut bacteria;gut microbiome;Heart;Human;In Vitro;in vivo;inhibitor;insight;Lesion;Lipopolysaccharides;loss of function;lymphatic malformations;Malignant Neoplasms;Modeling;Molecular;mouse genetics;mouse model;Mus;mutant;Mutation;novel;novel therapeutic intervention;Operative Surgical Procedures;Pathogenesis;Pathway interactions;Patients;Peptide Hydrolases;Pharmaceutical Preparations;pharmacologic;Pharmacotherapy;Phenotype;PIK3CA gene;PIK3CG gene;Play;postnatal;prevent;Proteins;Proteoglycan;Proteolysis;Resected;Role;Sampling;Signal Transduction;Sirolimus;Stroke;Supporting Cell;synergism;Testing;Therapeutic;TLR4 gene;Translating;Venous Malformation;versican;Zebrafish

PROJECT_TITLE: Downstream molecular mechanisms underlying cerebral cavernous malformation


NIH_SPENDING_CATS: Cardiovascular;Heart Disease;Hematology

ORG_CITY: SAINT LOUIS

ORG_NAME: WASHINGTON UNIVERSITY

ORG_STATE: MO

PHR: PROJECT NARRATIVE This training program aims to provide training and mentoring to a diverse group of undergraduate and health professional students from racial/ethnic groups traditionally underrepresented in health-related sciences on a national basis. The students will participate in scientific research, academic and professional development program in cardiovascular disease and hematologic disorders to help enhance the diversity of the next generation of leaders in the biomedical, behavioral and clinical research workforce in the topical areas of relevance to NHLBI.

PI_NAMEs: DAVILA-ROMAN, VICTOR G. (contact)

PROGRAM_OFFICER_NAME: HUANG, LI-SHIN

PROJECT_TERMS: Affect;Area;Attitude;Behavioral Research;Biomedical Research;Biometry;Blood Platelet Disorders;burden of illness;Cardiovascular Diseases;career;career development;Cerebrovascular Disorders;Clinical;Clinical Research;Clinical Trials;Coagulation Process;cohort;Communication;comorbidity;Coronary heart disease;Creativeness;Data Science;Development;disability;disadvantaged background;Disease;Disparity in diagnosis;Diverse Workforce;Education;education research;Educational Activities;Educational process of instructing;Ensure;Epidemiology;Equity;Ethnic Population;experience;Exposure to;Faculty;faculty mentor;Fostering;Foundations;Funding;Future;global health;Goals;hands on research;Health;Health Professional;Heart Diseases;Hematological Disease;Hematology;Hemoglobinopathies;Hemorrhage;Hypertension;implementation science;Individual;Infrastructure;interdisciplinary approach;interest;Knowledge;Leadership;Learning;lectures;Medicine;Mentors;Mission;Morbidity - disease rate;mortality;National Heart, Lung, and Blood Institute;next generation;Pediatric Research;Peripheral arterial disease;Persons;Population;professional students;Program Development;programs;Public Health;racial population;recruit;Research;research and development;Research Ethics;Research Personnel;Research Training;Resources;response;Role;Science;Series;skills;Stroke;Structure;Students;summer research;Syndrome;Training;training opportunity;Training Programs;Translational Research;undergraduate research experience;undergraduate student;Universities;Washington

PROJECT_TITLE: Washington University SummeR reseArch DIversity ProgrAm iN Cardiovascular Disease & HEmatology (RADIANCE)


NIH_SPENDING_CATS: Brain Disorders;Digestive Diseases;Genetics;Headaches;Migraine;Neurosciences;Pain Research

ORG_NAME: BOSTON CHILDREN'S HOSPITAL

PHR: PROJECT NARRATIVE Medications targeting the CGRP signaling pathway are increasingly used for migraine headaches, but constipation is a common side effect. CGRP is produced by an important group of nerve cells in the intestine, but its functions in these cells are not clear. This proposal aims to determine how intestinal CGRP and the nerve cells that make CGRP regulate gastrointestinal (GI) motility; this knowledge will help minimize side effects of anti-CGRP medications and show whether they could be used to treat GI dysmotility.

PI_NAMEs: RAO, MEENAKSHI  (contact)

PROGRAM_OFFICER_NAME: SHEA-DONOHUE, TEREZ

PROJECT_TERMS: Ablation;Address;Affect;Afferent Neurons;Amino Acids;Biology;Breeding;Calcitonin Gene-Related Peptide;Calcitonin-Gene Related Peptide Receptor;calcium indicator;cell type;Cells;Chromosomes;Clinical;Colon;Complex;Constipation;Data;Digestive System Disorders;Disease;Diverticulosis;Drug Targeting;Enteral;Enteric Nervous System;Enzyme-Linked Immunosorbent Assay;experience;Feces;Female;Frequencies;gastrointestinal;Gastrointestinal Diseases;Gastrointestinal Motility;Gastrointestinal tract structure;Gastrointestinal Transit;Gene Expression;Genes;Genetic;genome wide association study;Goals;gut health;Gut Mucosa;Health;Heterogeneity;Homeostasis;Human;Immune response;Immunity;Immunohistochemistry;In Vitro;in vivo;in vivo evaluation;intestinal homeostasis;Intestines;Knock-in Mouse;Knock-out;Knowledge;Label;Link;male;Migraine;migraine treatment;Modeling;Molecular;molecular phenotype;Motility;motility disorder;Mucosal Immunity;Mus;Neuroglia;neuromuscular function;Neurons;Neuropeptides;Nociception;novel;Pathway interactions;Patients;Pattern;Peptide Signal Sequences;Pharmaceutical Preparations;pharmacologic;Play;preservation;Protein Isoforms;Proteins;Puberty;receptor;Regulation;Relaxation;Reporter;Reporting;Role;Series;sex;Sex Differences;side effect;Signal Pathway;signal recognition particle receptor;Signal Transduction;single-cell RNA sequencing;Smooth Muscle;Source;Symptoms;Testing;tool;Transcript;Vasodilation;virtual;Visceral pain;Work

PROJECT_TITLE: Isoform- and Sex-Specific Functions of CGRP in Gastrointestinal Motility

STUDY_SECTION: DNPD

STUDY_SECTION_NAME: Digestive and Nutrient Physiology and Diseases Study Section [DNPD]


ADMINISTERING_IC: EY

IC_NAME: NATIONAL EYE INSTITUTE

NIH_SPENDING_CATS: Eye Disease and Disorders of Vision

ORG_DEPT: OPHTHALMOLOGY

PHR: PROJECT NARRATIVE This proposal seeks support for a program at the University of Michigan to train graduate students and postdoctoral fellows in vision research. Research performed by doctoral students and postdoctoral fellows supported by this training grant directly addresses problems in basic and translational science with important implications for understanding normal biological processes that impact human vision and diseases that result in vision loss. Training students and postdoctoral fellows adds to the workforce of outstanding vision scientists in academic and applied research and advances our knowledge in areas that are important for improving human health.

PI_NAMEs: FORT, PATRICE E. (contact)

PROGRAM_OFFICER_NAME: CLAYTON, EDWIN C

PROJECT_TERMS: Training Programs;Vision research

PROJECT_TITLE: Vision Research Training Program


ED_INST_TYPE: SCHOOLS OF NURSING

ORG_CITY: ARLINGTON

ORG_DEPT: OTHER HEALTH PROFESSIONS

ORG_NAME: UNIVERSITY OF TEXAS ARLINGTON

PHR: Project Narrative The National Institutes of Health (NIH) has made it a priority to address a disparity in the participation of underrepresented minority populations in the biomedical, behavioral and clinical research workforce. The University of Texas at Arlington is a large research institution that has a minority majority undergraduate population (~35,000 undergraduate students) and thus is an ideal institution to address the need to promote diversity. This program will expose 50 different underrepresented minority undergraduate students each year for 5 consecutive years (250 students total), to a rigorous 10-week summer research education experience with the goal of increasing underrepresented minorities in the future biomedical research workforce.

PI_NAMEs: BROTHERS, ROBERT MATTHEW (contact);NELSON, MICHAEL DOUGLAS

PROJECT_TERMS: Accounting;Address;Advisory Committees;African American;Age;Area;Asian;Bachelor's Degree;Behavioral Research;Biomedical Research;classroom research;Clinical Research;cohort;college;Degree program;design;Development;disabled students;Discipline;Disparity;Education;education research;Employment;Enrollment;ethnic diversity;experience;Exposure to;Extramural Activities;Faculty;faculty mentor;falls;Fellowship;Funding;Future;Goals;graduate school;graduate student;Health;higher education;Hispanic;Hispanic Populations;Hispanic-serving Institution;Hour;Individual;innovation;Institution;International;Joints;Laboratories;laboratory experience;Laboratory Research;Lead;Military Personnel;Minority;Minority Groups;minority undergraduate;Minority-Serving Institution;Mission;multidisciplinary;National Heart, Lung, and Blood Institute;news;Persons;Population;Positioning Attribute;primary outcome;Productivity;programs;Qualifying;Reporting;Research;Research Activity;Resources;responsible research conduct;school district;Series;STEM field;Students;success;summer research;Texas;Time;Training Programs;undergraduate research experience;undergraduate student;Underrepresented Minority;underrepresented minority student;Underrepresented Populations;United States National Institutes of Health;Universities;university student

PROJECT_TITLE: UTA Summer Undergraduate Research Program to Promote Diversity in Health Related Research


NIH_SPENDING_CATS: Genetics;Infectious Diseases

PHR: Project Narrative The molecular architecture of nonself recognition, including microbial perception and innate immune signaling, bears remarkable similarity from plants to worms, insects, and mammals. Our genetic and biochemical studies on elucidating the signaling networks orchestrating plant immune activation while avoiding autoimmunity reveal the molecular basis of plant defense and shed light on the evolutionarily convergent mechanisms in cellular signaling of animal innate immunity. Our study is relevant to the mission of NIH and is fundamental for basic medical research.

PI_NAMEs: HE, PING  (contact)

PROGRAM_OFFICER_NAME: ZHAO, XIAOLI

PROJECT_TERMS: Address;ADP ribosylation;Animals;Arabidopsis;Architecture;Area;Autoimmune Diseases;Autoimmunity;Biochemical;Biological Models;Cell Death;Cell membrane;Cell surface;Cells;combinatorial;Complex;Defect;Genes;Genetic;Genetic Screening;Genetic Transcription;Goals;graduate student;Homeostasis;Immune;immune activation;Immune response;Immune signaling;Immune system;Immunity;Immunologic Receptors;Infection;Infection prevention;Innate Immune Response;Innate Immune System;Insecta;Interdisciplinary Study;Knowledge;Laboratories;Ligands;Link;Mammals;MAP Kinase Modules;Mediating;Medical Research;microbial;Mission;Molecular;Natural Immunity;pathogen;Pathogen detection;Pattern;Pattern recognition receptor;Peptides;Perception;Phosphorylation;Phosphotransferases;Plants;Post-Translational Protein Processing;Post-Translational Regulation;Postdoctoral Fellow;posttranscriptional;receptor;Receptor Activation;receptor-mediated signaling;Research;Series;Signal Pathway;Signal Transduction;Toll-like receptors;training opportunity;Translations;Ubiquitination;undergraduate student;United States National Institutes of Health

PROJECT_TITLE: Signaling activation and constraints in maintaining immune homeostasis

STUDY_SECTION: MRAC

STUDY_SECTION_NAME: Maximizing Investigators' Research Award C Study Section[MRAC]


ED_INST_TYPE: ORGANIZED RESEARCH UNITS

NIH_SPENDING_CATS: Basic Behavioral and Social Science;Behavioral and Social Science;Genetics;Mental Health;Pediatric;Prevention;Social Determinants of Health

ORG_DEPT: BIOSTATISTICS & OTHER MATH SCI

PHR: PROJECT NARRATIVE This educational program will teach tools for international population research focusing on topics such as child health and wellbeing and the role of community resources, mental health and genetic factors in shaping population variation and change. These tools will significantly enhance the ability of population and health scientists to test the external validity of their hypotheses and assess the generalizability of key findings to a wide range of populations.

PI_NAMEs: AXINN, WILLIAM G. (contact)

PROGRAM_OFFICER_NAME: CAPPS, RANDOLPH CHRISTOPHER

PROJECT_TERMS: Age;Anemia;Archives;Attitude;Behavior;Behavioral;Behavioral Sciences;Belief;Blood;British;Characteristics;Child;Child Health;Child Welfare;Commerce;Communities;comparative;Conflict (Psychology);Continuing Education;Contraceptive Usage;control trial;Cross-Sectional Studies;Data;data resource;Demographic and Health Surveys;design;digital media;DNA;E-learning;Education;education research;Educational Activities;Educational process of instructing;Educational workshop;Elements;Employment;Environment;Europe;Evaluation;Event;experience;Family;Family member;Family Relationship;Family Study;General Population;Genes;Genetic;Genetic study;Health;high standard;Household;Human;human subject protection;improved;Income;innovation;Interdisciplinary Study;International;Interview;Investments;Learning;Life Cycle Stages;life history;Link;Longitudinal Studies;Los Angeles;Measurement;Measures;media use;Mental Health;Migrant;migration;Multimedia;National Institute of Child Health and Human Development;Neighborhoods;Nepal;Online Systems;panel study of income dynamics;Personal Satisfaction;Phenotype;Population;Population Dynamics;Population Research;Population Sciences;Population Study;programs;Public Policy;randomized, controlled study;Randomized, Controlled Trials;Registries;Research;Research Design;Resources;Risk;Role;Sampling;Science;Scientist;Series;Shapes;skills;social;Social Sciences;study population;surveillance data;Survey Methodology;Surveys;Testing;Time;tool;Training;Training Programs;United States;Variant;Violence;Western Europe

PROJECT_TITLE: Interdisciplinary Research Training Program for International Population Science

STUDY_SECTION: CHHD

STUDY_SECTION_NAME: Population Sciences Study Section[CHHD-W]


NIH_SPENDING_CATS: Acquired Cognitive Impairment;Aging;Alzheimer's Disease;Alzheimer's Disease Related Dementias (ADRD);Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD);Brain Disorders;Cardiovascular;Cerebrovascular;Dementia;Neurodegenerative;Neurosciences;Vascular Contributions to Cognitive Impairment and Dementia (VCID)

ORG_CITY: AUGUSTA

ORG_DEPT: PHYSIOLOGY

ORG_NAME: AUGUSTA UNIVERSITY

PHR: PROJECT NARRATIVE Diastolic heart failure (dHF) and Alzheimer’s disease (AD) are both prevalent diseases where there is a poor understanding of the underlying mechanisms behind the disease. Microvascular dysfunction has been implicated in playing a role in both diseases, but importantly has been shown to underlie the development of cognitive impairment; this project will examine the vascular contributions in a mixed dHF/AD pathology as well as investigate the underlying molecular mechanisms. Through my proposed studies, I aim to better understand the pathological role of adenosine kinase (ADK) in vascular dysfunction and eventual cognitive impairment in a mixed dHF/AD pathology.

PI_NAMEs: FOPIANO, KATIE ANNE  (contact)

PROGRAM_OFFICER_NAME: MATTHEWS, MARGUERITE

PROJECT_TERMS: Acceleration;Address;Adenosine;Adenosine Kinase;adenosine monophosphate-adenosine;adenovirus mediated delivery;Affect;Aldosterone;Alzheimer's Disease;Alzheimer's disease pathology;Alzheimer's disease patient;Amyloid beta-Protein Precursor;Anti-Inflammatory Agents;Astrocytes;Automobile Driving;behavior test;Blood flow;Blood Vessels;Brain;Brain region;Cardiovascular Physiology;Cardiovascular system;Cell Culture Techniques;cerebrovascular;Cerebrovascular Circulation;Cerebrovascular Disorders;Cerebrum;Chronic;Clinical;Clinical Research;Cognitive;Cognitive deficits;cognitive function;Complex;Data;Dementia;dementia risk;Development;Diastolic heart failure;Disease;Endothelial Cells;Endothelium;Endothelium-Dependent Relaxing Factors;Exhibits;experimental study;Functional disorder;Genetic;Goals;Human;hypoperfusion;Hypoxia;Impaired cognition;Impairment;improved;in vivo;in vivo two-photon imaging;Individual;Inflammation Mediators;Inflammatory;Infusion procedures;Ischemia;kinase inhibitor;knock-down;Laboratories;Lasers;Measures;Memory;Metabolism;Microglia;Microvascular Dysfunction;Molecular;mouse model;Mouse Protein;Mus;mutant;Neurodegenerative Disorders;Neurons;neuropathology;neuroprotection;neurovascular;neurovascular coupling;novel;Outcome;parenchymal arterioles;Pathologic;Pathology;Patients;Perfusion;pharmacologic;Physiological;Play;Population;pressure;Process;Protein Precursors;Protocols documentation;receptor;response;Risk Factors;Rodent Model;Role;Sensory;Signal Pathway;spatiotemporal;targeted treatment;Testing;Therapeutic;Therapeutic Intervention;Transgenic Mice;vascular contributions;Vascular Diseases;Vascular Endothelial Cell;vascular endothelial dysfunction;Vascular Endothelium;Vasodilator Agents;Vasomotor;Vibrissae

PROJECT_TITLE: The Role of Adenosine Kinase in Mixed Diastolic Heart Failure and Alzheimer Disease


NIH_SPENDING_CATS: Bioengineering;Nanotechnology

ORG_CITY: UNIVERSITY PARK

ORG_DEPT: BIOMEDICAL ENGINEERING

ORG_NAME: PENNSYLVANIA STATE UNIVERSITY, THE

PHR: Project Narrative Bidirectional transport of cargo in cells and neurons is carried out by two antagonistic microtubule motors, kinesin, and dynein; however, how these motors coordinate to determine the direction of transport is unknown. Defects in cellular cargo transport are linked to neurodegenerative diseases, such as Alzheimer’s and amyotrophic lateral sclerosis (ALS), emphasizing the importance of understanding the underlying mechanism of bidirectional transport. This project will use novel high-resolution microscopy techniques to track and analyze the complex interplay between molecular motors as they transport cargo along microtubules.

PI_NAMEs: NOELL, CRYSTAL RENEA (contact)

PROGRAM_OFFICER_NAME: AKACEM, LAMEESE DANA

PROJECT_TERMS: Acceleration;Affect;Alzheimer's Disease;Amyotrophic Lateral Sclerosis;Binding;Binding Sites;Cell division;Cells;Characteristics;Complex;Computer Models;Defect;Diffusion;dimer;Disease;DNA;dynactin;Dynein ATPase;Ensure;experimental study;Fluorescence Microscopy;Fluorescent Probes;Geometry;Goals;Gold;Growth;Head;Huntington Disease;in vivo;Individual;insight;Intracellular Transport;Investigation;Kinesin;Kinetics;Label;laser tweezer;Link;Linker DNA;Location;Microscopy;Microtubules;Modeling;Molecular;Molecular Motors;Motor;nanoGold;Neurodegenerative Disorders;Neurons;novel;optic tweezer;Parkinson Disease;particle;Physiological;Property;Resolution;scaffold;simulation;single molecule;Single-Stranded DNA;Spinal Muscular Atrophy;System;Techniques;Testing;tool;Total Internal Reflection Fluorescent;trafficking;Work

PROJECT_TITLE: Molecular motor dynamics underlying bidirectional cargo transport in cells

STUDY_SECTION_NAME: Special Emphasis Panel[ZRG1-F05-D(21)L]


ORG_CITY: STANFORD

ORG_NAME: STANFORD UNIVERSITY

ORG_STATE: CA

PHR: PROJECT NARRATIVE This renewal of the T32 Stanford Vision Training Program will continue to fund a premier postdoctoral training program designed to integrate excellence in basic vision research and clinical ophthalmologic training. Our explicit goal is to produce investigators capable of using basic research to answer clinically relevant questions. Program components include rigorous research programs with vision faculty of the highest caliber, vision research community events, comprehensive eye and vision courses, and clinical ophthalmologic exposure to facilitate future bench-to-bedside applications of basic vision research.

PI_NAMEs: GOLDBERG, JEFFREY L (contact)

PROJECT_TERMS: Training Programs;Vision

PROJECT_TITLE: Stanford Vision Training Program


ORG_CITY: NEW ORLEANS

ORG_NAME: TULANE UNIVERSITY OF LOUISIANA

ORG_STATE: LA

PHR: Narrative Currently there is no successful treatment that restores damaged brain circuitry. Direct reprogramming approaches hold great promise for brain repair since they can convert differentiated cells from multiple sources into neurons in vivo. Important challenges for the application of cell reprogramming strategies to circuit repair that derive from the current lack of precision in generating specific types of neurons with functional properties matching the endogenous neurons in the brain. Precise conversion between neuron subtypes can be induced within the developing brain, but not in mature neurons. Identifying the mechanisms that keep neuron subtype identity unchanged in mature neurons will reveal barriers that preclude functional conversion between neuron subtypes in vivo. We propose to investigate these mechanisms in the cerebral cortex, produce a clinically relevant cortical neuron subtype

PI_NAMEs: GALAZO, MARIA J (contact)

PROGRAM_OFFICER_NAME: LAVAUTE, TIMOTHY M

PROJECT_TERMS: Amyotrophic Lateral Sclerosis;Axon;axon injury;Behavior;Brain;brain circuitry;Brain Injuries;brain repair;Brain Stem;Cell Differentiation process;Cell Reprogramming;Cells;Cerebral cortex;clinically relevant;Data;Degenerative Disorder;Embryo;Evaluation;experimental study;frontotemporal lobar dementia amyotrophic lateral sclerosis;Genetic Transcription;Goals;Health;Human;Impaired cognition;in vitro testing;in vivo;Injury;Life;Maintenance;Membrane;Molecular;Motor;Movement;Mus;Mutation;neural circuit;Neurodegenerative Disorders;Neurologic Dysfunctions;neuron loss;Neuronal Differentiation;Neurons;Output;Paralysed;Population;programs;Property;repaired;response;restoration;Signal Pathway;Signal Transduction;Source;Spinal Cord;Spinal cord damage;Spinal cord injury;success;Testing;Thalamic structure;Time;transcriptome;Trauma;Work

PROJECT_TITLE: Molecular Determinants for In vivo Functional Reprogramming of Cortical Output Neurons and Circuits

STUDY_SECTION: NDPR

STUDY_SECTION_NAME: Neurodifferentiation, Plasticity, Regeneration and Rhythmicity Study Section[NDPR]